bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tools and tactics for postdischarge medication management interventions
Authors: Pevnick Joshua M , Anderson Laura J , Chirumamilla Siri , Luong Duong D , Noh Lydia E , Palmer Katherine , Amer Kallie , Shane Rita R , Nuckols Teryl K , Lesser Rachel B , Schnipper Jeffrey L 
Published: February 2021

Abstract

Purpose
To identify interventions for organizational pharmacist-leaders and frontline pharmacy staff to optimize peri- and postdischarge medication management.

Summary
An evidence-based toolkit was systematically constructed on the basis of findings of 3 systematic overviews of systematic reviews. The interventions were reviewed by a technical expert panel and categorized as either tools or tactics. The identified tools are instruments such as diagrams, flow charts, lists, tables, and templates used in performing a distinct operation, whereas identified tactics reflect broader methods (eg, reduced dosing frequency). Tools and tactics were chosen on the basis of their potential to improve postdischarge medication management, with a focus on interventions led by pharmacy staff that may reduce hospital readmissions among older, sicker patients. Overall, 23 tools and 2 tactics were identified. The identified tools include items such as education, text messaging, and phone calls. The tactics identified are dose simplification and monetary incentives. Practical information has also been provided to facilitate implementation.

Conclusion
Several tools and tactics are available to optimize peri- and postdischarge medication management. Organizational pharmacist-leaders and frontline pharmacy staff can implement these interventions to improve patient outcomes.
Increasing rural patient access using clinical pharmacy specialist providers: Successful practice integration within the Department of Veterans Affairs
Authors: Groppi Julie A , Ourth Heather , Tran Michael , Morreale Anthony P , McFarland Michael Shawn , Moore Tera D , Jorgenson Terri , Torrise Virginia 
Published: February 2021

Abstract

Purpose
Access to care is a critical issue facing healthcare and affects patients living in rural and underserved areas more significantly. This led the Department of Veterans Affairs (VA) to launch a project that leveraged the expertise of the clinical pharmacy specialist (CPS) provider, embedding 180 CPS providers into primary care, mental health, and pain management across the nation.

Methods
This multidimensional project resulted in hiring 111 CPS providers in primary care, 40 CPS providers in mental health, and 35 CPS providers in pain management to serve rural veterans’ needs. From October 2017 to March 2020, CPS providers provided direct patient care to 213,477 veterans within 606,987 visits. This was an average of 43,000 additional visits each quarter to support comprehensive medication management services, demonstrating an additional 219,823 visits in fiscal year 2018 and 232,030 visits in fiscal year 2019. Over the course of the project, the team provided mentorship to 164 CPS providers, performed consultative visits at 27 VA facilities, and trained 180 CPS providers in educational boot camps.

Conclusion
VA funding of rural health initiatives adding CPS providers to primary care, mental health, and pain teams has resulted in positive measures of comprehensive medication management, interdisciplinary team satisfaction, facility leadership acceptance, and multiple positive outcomes.
Production of a new triterpenoid disaccharide saponin from sequential glycosylation of ganoderic acid A by 2 Bacillus glycosyltransferases
Authors: Chang Te-Sheng , Chiang Chien-Min , Wu Jiumn-Yih , Tsai Yu-Li , Ting Huei-Ju 
Published: February 2021

ABSTRACT
Ganoderic acid A (GAA) is a lanostane-type triterpenoid, isolated from medicinal fungus Ganoderma lucidum, and possesses multiple bioactivities. In the present study, GAA was sequentially biotransformed by 2 recently discovered Bacillus glycosyltransferases (GT), BtGT_16345 and BsGT110, and the final product was purified and identified as a new compound, GAA-15,26-O-β-diglucoside, which showed 1024-fold aqueous solubility than GAA.
NMCMDA: neural multicategory MiRNA–disease association prediction
Authors: Wang Jingru , Li Jin , Yue Kun , Wang Li , Ma Yuyun , Li Qing 
Published: February 2021

AbstractMotivationThere is growing evidence showing that the dysregulations of miRNAs cause diseases through various kinds of the underlying mechanism. Thus, predicting the multiple-category associations between microRNAs (miRNAs) and diseases plays an important role in investigating the roles of miRNAs in diseases. Moreover, in contrast with traditional biological experiments which are time-consuming and expensive, computational approaches for the prediction of multicategory miRNA–disease associations are time-saving and cost-effective that are highly desired for us.ResultsWe present a novel data-driven end-to-end learning-based method of neural multiple-category miRNA–disease association prediction (NMCMDA) for predicting multiple-category miRNA–disease associations. The NMCMDA has two main components: (i) encoder operates directly on the miRNA–disease heterogeneous network and leverages Graph Neural Network to learn miRNA and disease latent representations, respectively. (ii) Decoder yields miRNA–disease association scores with the learned latent representations as input. Various kinds of encoders and decoders are proposed for NMCMDA. Finally, the NMCMDA with the encoder of Relational Graph Convolutional Network and the neural multirelational decoder (NMR-RGCN) achieves the best prediction performance. We compared the NMCMDA with other baselines on three experimental datasets. The experimental results show that the NMR-RGCN is significantly superior to the state-of-the-art method TDRC in terms of Top-1 precision, Top-1 Recall, and Top-1 F1. Additionally, case studies are provided for two high-risk human diseases (namely, breast cancer and lung cancer) and we also provide the prediction and validation of top-10 miRNA–disease-category associations based on all known data of HMDD v3.2, which further validate the effectiveness and feasibility of the proposed method.
Procne in Toni Morrison’s Beloved
Authors: Cullhed Sigrid Schottenius 
Published: February 2021

Abstract
Sethe Suggs, the protagonist in Toni Morrison’s novel Beloved, is often compared to Medea. The same analogy with the Colchian princess was often made by contemporaries in relation to Margaret Garner, the historical person on whose life the novel is loosely based. An enslaved African-American woman in the mid-nineteenth century, Garner killed her own daughter after being found by her former owner and was styled a ‘Modern Medea’ in the press. Despite Morrison’s dislike of the comparison as well as its obvious asymmetries, it has become so prominent in recent scholarship on Beloved that it tends to eclipse other elements of classical mythology in the novel. This article explores the hermeneutic productivity of reading Sethe’s infanticide against the backdrop of the myth of Procne and Philomela.
The reduced left ventricular stroke volume does not fully recover after pulmonary valve replacement in patients with repaired tetralogy of Fallot
Authors: Yasukawa Takashi , Hoashi Takaya , Imai Kenta , Okuda Naoki , Fukuda Tetsuya , Ohuchi Hideo , Kurosaki Kenichi , Ichikawa Hajime 
Published: February 2021

Abstract

OBJECTIVES
The present study was conducted to investigate the decrease in left ventricular stroke volume index (LVSVI) that is caused by pulmonary regurgitation-induced right heart dysfunction and its clinical implications before and after pulmonary valve replacement (PVR).

METHODS
Between January 2010 and December 2019, 30 adults who underwent surgical PVR for chronic pulmonary regurgitation with right ventricular dilation late after tetralogy of Fallot (TOF) repair were included. All patients were evaluated using cardiac magnetic resonance before PVR. The median interval from TOF repair to PVR was 29 [25th, 75th percentile: 25, 37] years. The median pulmonary regurgitation fraction and right ventricular end-diastolic volume index were 56 [48, 66] % and 203 [187, 239] ml/m2. Twenty-three patients (76.7%) were re-evaluated 1 year after PVR.

RESULTS
Before PVR, the median LVSVI was 40 [35, 46] ml/beat/m2. A lower LVSVI was associated with a longer interval from TOF repair to PVR (r = −0.40, P = 0.029) and a lower right ventricular ejection fraction (r = 0.52, P = 0.004). A lower LVSVI was not associated with a higher right ventricular end-diastolic volume index. LVSVI remained unchanged after PVR. The patients were subdivided into Normal-stroke volume index (SVI) and Subnormal-SVI groups using the preoperative LVSVI cut-off value of 35 mL/beat/m2. Compared with the Normal-SVI group, the Subnormal-SVI group had a higher incidence of ablation therapy before PVR (4.7 vs 2.3 patient-years, P = 0.044). After PVR, LVSVI in the Subnormal-SVI group was still lower (40 [34, 42] vs 44 [42, 47] ml/beat/m2, P = 0.038) despite the right ventricular end-diastolic volume index normalization. There was no difference in the clinical event incidence between the 2 groups during the follow-up period. Brain natriuretic peptide level in the Subnormal-SVI group was higher within 3 years after PVR (P = 0.046).

CONCLUSIONS
Reduced left ventricular stroke volume did not fully recover after PVR. PVR for patients with repaired TOF should be performed before the left ventricular stroke volume begins to decrease.
Using metaphor elicitation with pre-primary children learning English
Authors: Ellis Gail , Ibrahim Nayr 
Published: February 2021

AbstractThis article reports on a study that investigates children’s experiences and perceptions of English language learning by using a metaphor elicitation technique. Giving children a voice in the early years recognizes children as individuals and as active and capable participants in their own learning. It gives both children and teachers an insight into the language learning process and contributes to a more learner-centred pedagogy. Previous studies using this technique have shown that children are creative and capable of giving their own metaphorical representations of their English language learning experiences both inside and outside the classroom. This study includes bilingual and EFL four- and five-year-olds’ representations in the form of a ‘My learning English senses’ zig-zag book, which provides an affective, personal record of their early English language learning experiences. The findings confirm the extent to which children of this age group operate mainly in the ‘here and now’.
Rates of gene conversions between Escherichia coli ribosomal operons
Authors: Gifford Isaac , Dasgupta Aurko , Barrick Jeffrey E 
Published: February 2021

Abstract
Due to their universal presence and high sequence conservation, ribosomal RNA (rRNA) sequences are used widely in phylogenetics for inferring evolutionary relationships between microbes and in metagenomics for analyzing the composition of microbial communities. Most microbial genomes encode multiple copies of rRNA genes to supply cells with sufficient capacity for protein synthesis. These copies typically undergo concerted evolution that keeps their sequences identical, or nearly so, due to gene conversion, a type of intragenomic recombination that changes one copy of a homologous sequence to exactly match another. Widely varying rates of rRNA gene conversion have previously been estimated by comparative genomics methods and using genetic reporter assays. To more directly measure rates of rRNA intragenomic recombination, we sequenced the seven Escherichia coli rRNA operons in 15 lineages that were evolved for ∼13,750 generations with frequent single-cell bottlenecks that reduce the effects of selection. We identified 38 gene conversion events and estimated an overall rate of intragenomic recombination within the 16S and 23S genes between rRNA copies of 3.6 × 10−4 per genome per generation or 8.6 × 10−6 per rRNA operon per homologous donor operon per generation. This rate varied only slightly from random expectations at different sites within the rRNA genes and between rRNA operons located at different positions in the genome. Our accurate estimate of the rate of rRNA gene conversions fills a gap in our quantitative understanding of how ribosomal sequences and other multicopy elements diversify and homogenize during microbial genome evolution.
Linking anthocyanin diversity, hue, and genetics in purple corn
Authors: Chatham Laura A , Juvik John A 
Published: February 2021

Abstract
While maize with anthocyanin-rich pericarp (purple corn) is rising in popularity as a source of natural colorant for foods and beverages, information on color range and stability—factors associated with anthocyanin decorations and compositional profiles—is currently limited. Furthermore, to maximize the scalability and meet growing demands, both anthocyanin concentrations and agronomic performance must improve in purple corn varieties. Using the natural anthocyanin diversity present in a purple corn landrace, Apache Red, we generated a population with variable flavonoid profiles—flavanol–anthocyanin condensed forms (0–83%), acylated anthocyanins (2–72%), pelargonidin-derived anthocyanins (5–99%), C-glycosyl flavone co-pigments up to 1904 µg/g, and with anthocyanin content up to 1598 µg/g. Each aspect of the flavonoid profiles was found to play a role in either the resulting extract hue or intensity. With genotyping-by-sequencing of this population, we mapped aspects of the flavonoid profile. Major quantitative trait loci (QTLs) for anthocyanin type were found near loci previously identified only in aleurone-pigmented maize varieties [Purple aleurone1 (Pr1) and Anthocyanin acyltransferase1 (Aat1)]. A QTL near P1 (Pericarp color1) was found for both flavone content and flavanol–anthocyanin condensed forms. A significant QTL associated with peonidin-derived anthocyanins near a candidate S-adenosylmethionine-dependent methyltransferase was also identified, warranting further investigation. Mapping total anthocyanin content produced signals near Aat1, the aleurone-associated bHLH R1 (Colored1), the plant color-associated MYB, Pl1 (Purple plant1), the aleurone-associated recessive intensifier, In1 (Intensifier1), and several previously unidentified candidates. This population represents one of the most anthocyanin diverse pericarp-pigmented maize varieties characterized to date. Moreover, the candidates identified here will serve as branching points for future research studying the genetic and molecular processes determining anthocyanin profile in pericarp.
Transposable Element Mobilization in Interspecific Yeast Hybrids
Authors: Smukowski Heil Caiti , Patterson Kira , Hickey Angela Shang-Mei , Alcantara Erica , Dunham Maitreya J 
Published: February 2021

AbstractBarbara McClintock first hypothesized that interspecific hybridization could provide a “genomic shock” that leads to the mobilization of transposable elements (TEs). This hypothesis is based on the idea that regulation of TE movement is potentially disrupted in hybrids. However, the handful of studies testing this hypothesis have yielded mixed results. Here, we set out to identify if hybridization can increase transposition rate and facilitate colonization of TEs in Saccharomyces cerevisiae × Saccharomyces uvarum interspecific yeast hybrids. Saccharomyces cerevisiae have a small number of active long terminal repeat retrotransposons (Ty elements), whereas their distant relative S. uvarum have lost the Ty elements active in S. cerevisiae. Although the regulation system of Ty elements is known in S. cerevisiae, it is unclear how Ty elements are regulated in other Saccharomyces species, and what mechanisms contributed to the loss of most classes of Ty elements in S. uvarum. Therefore, we first assessed whether TEs could insert in the S. uvarum sub-genome of a S. cerevisiae × S. uvarum hybrid. We induced transposition to occur in these hybrids and developed a sequencing technique to show that Ty elements insert readily and nonrandomly in the S. uvarum genome. We then used an in vivo reporter construct to directly measure transposition rate in hybrids, demonstrating that hybridization itself does not alter rate of mobilization. However, we surprisingly show that species-specific mitochondrial inheritance can change transposition rate by an order of magnitude. Overall, our results provide evidence that hybridization can potentially facilitate the introduction of TEs across species boundaries and alter transposition via mitochondrial transmission, but that this does not lead to unrestrained proliferation of TEs suggested by the genomic shock theory.
The rates of introgression and barriers to genetic exchange between hybridizing species: sex chromosomesvsautosomes
Authors: Fraïsse Christelle , Sachdeva Himani 
Published: February 2021

AbstractInterspecific crossing experiments have shown that sex chromosomes play a major role in reproductive isolation between many pairs of species. However, their ability to act as reproductive barriers, which hamper interspecific genetic exchange, has rarely been evaluated quantitatively compared to Autosomes. This genome-wide limitation of gene flow is essential for understanding the complete separation of species, and thus speciation. Here, we develop a mainland-island model of secondary contact between hybridizing species of an XY (or ZW) sexual system. We obtain theoretical predictions for the frequency of introgressed alleles, and the strength of the barrier to neutral gene flow for the two types of chromosomes carrying multiple interspecific barrier loci. Theoretical predictions are obtained for scenarios where introgressed alleles are rare. We show that the same analytical expressions apply for sex chromosomes and autosomes, but with different sex-averaged effective parameters. The specific features of sex chromosomes (hemizygosity and absence of recombination in the heterogametic sex) lead to reduced levels of introgression on the X (or Z) compared to autosomes. This effect can be enhanced by certain types of sex-biased forces, but it remains overall small (except when alleles causing incompatibilities are recessive). We discuss these predictions in the light of empirical data comprising model-based tests of introgression and cline surveys in various biological systems.
Associations Between Potentially Modifiable and Nonmodifiable Risk Factors and Gait Speed in Middle- and Older-Aged Adults: Results From the Canadian Longitudinal Study on Aging
Authors: Figgins Erica , Choi Yun-Hee , Speechley Mark , Montero-Odasso Manuel 
Published: February 2021

Abstract

Background
Gait speed is a strong predictor of morbidity and mortality in older adults. Understanding the factors associated with gait speed and the associated adverse outcomes will inform mitigation strategies. We assessed the potentially modifiable and nonmodifiable factors associated with gait speed in a large national cohort of middle and older-aged Canadian adults.

Methods
We examined cross-sectional baseline data from the Canadian Longitudinal Study on Aging (CLSA) Comprehensive cohort. The study sample included 20 201 community-dwelling adults aged 45–85 years. The associations between sociodemographic and anthropometric factors, chronic conditions, and cognitive, clinical, and lifestyle factors and 4-m usual gait speed (m/s) were estimated using hierarchical multivariable linear regression.

Results
The coefficient of determination, R 2, of the final regression model was 19.7%, with 12.9% of gait speed variability explained by sociodemographic and anthropometric factors, and nonmodifiable chronic conditions and 6.8% explained by potentially modifiable chronic conditions, cognitive, clinical, and lifestyle factors. Potentially modifiable factors significantly associated with gait speed include cardiovascular conditions (unstandardized regression coefficient, B = −0.018; p &lt; .001), stroke (B = −0.025; p = .003), hypertension (B = −0.007; p = .026), serum Vitamin D (B = 0.004; p &lt; .001), C-reactive protein (B = −0.005; p = .005), depressive symptoms (B = −0.003; p &lt; .001), physical activity (B = 0.0001; p &lt; .001), grip strength (B = 0.003; p &lt; .001), current smoking (B = −0.026; p &lt; .001), severe obesity (B = −0.086; p &lt; .001), and chronic pain (B = −0.008; p = .018).

Conclusions
The correlates of gait speed in adulthood are multifactorial, with many being potentially modifiable through interventions and education. Our results provide a life-course-perspective framework for future longitudinal assessments risk factors affecting gait speed.
Age-Related Changes in the Role of Social Motivation: Implications for Healthy Aging
Authors: Isaacowitz Derek M , Freund Alexandra M , Mayr Ulrich , Rothermund Klaus , Tobler Philippe N 
Published: February 2021

Abstract
Prior research has established the importance of social relations and social embeddedness for motivation in healthy aging. Thus, social orientation appears to be essential for understanding healthy aging. This article focuses particularly on age-related changes in goals concerning social orientation, such as increased prioritization of emotional goals, increased prosociality/altruistic motives, generativity, and ego transcendence. We then consider open questions regarding gaps in the links between goals related to social orientation and healthy aging, as well as the implications of theories and research on social goals for leveraging motivation to promote healthy aging. In particular, interventions to promote healthy behavior in late life may be most effective when they match the themes of older adults’ strivings to find meaning and purpose in their personal goals.
Late results after mitral valve replacement with Mosaic bioprosthesis in patients aged 65 years or younger
Authors: Chiariello Giovanni A , Beraud Anne-Sophie , Vahdat Olivier , Van Rothem Jérôme , Garcia Olivier , Soula Philippe , Berthoumieu Pierre , Abouliatim Issam 
Published: February 2021

Abstract

OBJECTIVES
Although in younger patients indications for biological prosthesis implantation in mitral valve replacement remain controversial, recently bioprostheses use increased considerably. We present late results obtained with the Medtronic Mosaic bioprosthesis in patients aged 65 years or younger.

METHODS
Between 2007 and 2017, 67 mitral Mosaic bioprostheses were implanted in patients aged 65 years or younger (58.5 ± 6.4 years). Follow-up extended up to 13 years. Survival, freedom from structural valve degeneration, endocarditis, thromboembolic events and reoperation were considered as main clinical end points evaluated at 1, 5 and 10 years.

RESULTS
The mean follow-up was 4.7 ± 2.8 years. Overall mortality rate was 12%. At 1, 5 and 10 years, survival was 94 ± 3%, 89 ± 4% and 77 ± 9%, respectively. Freedom from structural valve degeneration was 100%, 94 ± 4% and 71 ± 21%. Freedom from endocarditis was 95 ± 3%, 90 ± 6% and 84 ± 8%. Freedom from thromboembolic events was 94 ± 3%, 90 ± 5% and 90 ± 5%. Freedom from reoperation was 94 ± 3%, 87 ± 5% and 65 ± 19%.

CONCLUSIONS
Mosaic bioprosthesis appears a valid mitral valve substitute even when employed in ≤65-year-old patients.