bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acetic Acid Mediated Electrochemical Synthesis of Benzazole and its Application in the Synthesis of Pharmaceutically Active Compounds
Authors: Ghoshal Tanay , Patel Tarun M. , Kotturi Sharadsrikar 
Published: August 2021

AbstractAn acetic acid promoted electrochemical synthesis of benzazoles, benzimidazoles, benzthiazoles and benzoxazoles, is reported. The method offers large substrate scope, good functional group tolerance, while using cheap electrolyte. The method uses acetic acid as the electrolyte which has a better solubility in methanol, hence the reaction time is less and product formation is observed in high yield without much side product. This electrochemical method is further utilised to synthesise thiabendazole, fuberidazole, chlormidazole and advance intermediates of bilastine and clemizole in good yields.
Installation of Diverse Succinimides at C‐8 Position of Quinoline N‐Oxides via Rhodium(III)‐Catalyzed C−H Functionalization
Authors: Nale Sagar D. , Aslam Mohammad , Lee Yong Rok 
Published: August 2021

AbstractThis paper describes a highly efficient rhodium‐catalyzed regioselective C−H bond functionalization of quinoline N‐oxides with maleimides to assemble multisubstituted heteroaryl succinimides. The developed C−H bond functionalization approach allows the regioselective installation of numerous succinimide frameworks on the C‐8 position of quinoline N‐oxides. This methodology exhibits the advantages of broad scope, low catalyst loading, and mild reaction conditions without requiring external oxidizing agents.
Highly Conductive Ligand‐Free Cs2PtBr6 Perovskite Nanocrystals with a Narrow Bandgap and Efficient Photoelectrochemical Performance
Authors: Peng Huaping , Xu Luyao , Sheng Yilun , Sun Weiming , Yang Yu , Deng Haohua , Chen Wei , Liu Juewen 
Published: August 2021

AbstractDesign of high‐performance all‐inorganic halide perovskites, especially lead‐free perovskites, is key to the broadening of its application prospects. Herein, the authors report the synthesis of ligand‐free cesium platinum (IV) bromide nanocrystals (Cs2PtBr6 NCs), a new kind of vacancy‐ordered lead‐free perovskite nanomaterial, by a facile one‐pot method. The Cs2PtBr6 NCs exhibits a narrow band gap of 1.32 eV covering the entire visible range, which is supported by density functional theory calculations. Together with their high conductivity, matching energy levels with the work function of carbon electrodes, and excellent environmental stability, this NC displays a cathodic photocurrent density as high as 335 µA cm‐2, two orders of magnitude higher than other perovskites in aqueous solutions without the need of other electron acceptors. These combined properties suggest that the Cs2PtBr6 NCs have great potentials in a wide range of photoelectronic and photoelectrochemical sensing applications.
Making ecosystem services flexible: Why a whole new framework is a bad idea for practitioners
Authors: Raheem Nejem , Schwarzmann Danielle 
Published: August 2021

AbstractTwo economists working in the field of ecosystem services and conservation discuss why a flexible approach to using any of the existing frameworks is probably better than creating a new and “ideal” framework. They describe work they have both done with NOAA's Office of National Marine Sanctuaries as an example of how to modify an ecosystem services framework to suit a range of cultural and ecological conditions.This article is categorized under:
Water and Life > Conservation, Management, and Awareness
Excited state Rényi entropy and subsystem distance in two-dimensional non-compact bosonic theory. Part II. Multi-particle states
Authors: Zhang Jiaju , Rajabpour M. A. 
Published: August 2021

Abstract
We study the excited state Rényi entropy and subsystem Schatten distance in the two-dimensional free massless non-compact bosonic field theory, which is a conformal field theory. The discretization of the free non-compact bosonic theory gives the harmonic chain with local couplings. We consider the field theory excited states that correspond to the harmonic chain states with excitations of more than one quasiparticle, which we call multi-particle states. This extends the previous work by the same authors to more general excited states. In the field theory we obtain the exact Rényi entropy and subsystem Schatten distance for several low-lying states. We obtain short interval expansion of the Rényi entropy and subsystem Schatten distance for general excited states, which display different universal scaling behaviors in the gapless and extremely gapped limits of the non-compact bosonic theory. In the locally coupled harmonic chain we calculate numerically the excited state Rényi entropy and subsystem Schatten distance using the wave function method. We find excellent matches of the analytical results in the field theory and numerical results in the gapless limit of the harmonic chain. We also make some preliminary investigations of the Rényi entropy and the subsystem Schatten distance in the extremely gapped limit of the harmonic chain.
Single production of vector-like quarks: the effects of large width, interference and NLO corrections
Authors: Deandrea Aldo , Flacke Thomas , Fuks Benjamin , Panizzi Luca , Shao Hua-Sheng 
Published: August 2021

Abstract
We provide a comprehensive discussion, together with a complete setup for simulations, relevant for the production of a single vector-like quark at hadron colliders. Our predictions include finite width effects, signal-background interference effects and next-to-leading order QCD corrections. We explicitly apply the framework to study the single production of a vector-like quark T with charge 2/3, but the same procedure can be used to analyse the single production of vector-like quarks with charge −4/3, −1/3, 2/3 and 5/3, when the vector-like quark interacts with the Standard Model quarks and electroweak bosons. Moreover, this procedure can be straightforwardly extended to include additional interactions with exotic particles. We provide quantitative results for representative benchmark scenarios characterised by the T mass and width, and we determine the role of the interference terms for a range of masses and widths of phenomenological significance. We additionally describe in detail, both analytically and numerically, a striking feature in the invariant mass distribution appearing only in the T → th channel.
Colony fitness increases in the honey bee at queen mating frequencies higher than genetic diversity asymptote
Authors: Delaplane Keith S. , Given J. Krispn , Menz John , Delaney Deborah A. 
Published: August 2021

Abstract
Across the eusocial Hymenoptera, a queen’s mating frequency is positively associated with her workers’ genetic diversity and colony’s fitness. Over 90% of a colony’s diversity potential is achieved by its mother’s tenth effective mating (me); however, many females mate at levels of me > 10, a zone we here call hyperpolyandry. We compared honey bee colony fitness at mating levels near and above this genetic diversity asymptote. We were interested in how hyperpolyandry affects colony phenotypes arising from both common tasks (brood care) and rare specialized tasks (parasite resistance). We used an unselected wild line of bees and a Varroa Sensitive Hygiene (VSH) line selected to resist the parasite Varroa destructor. Virgin queens were instrumentally inseminated to replicate the following queen/colony conditions: (1) VSH semen/low polyandry (observed mating number = mo = 9), (2) VSH semen/high polyandry (mo = 54), (3) wild type semen/low polyandry, or (4) wild semen/high polyandry. There was a positive effect of polyandry on brood survival, an outcome of common tasks, with highest values at mo = 54. There was an interaction between polyandry and genetics such that differences between genetic lines expressed only at mo = 54, with fewer mites in VSH colonies. These results are consistent with two hypotheses for the evolution of mating levels in excess of the genetic diversity asymptote: hyperpolyandry improves colony fitness by (1) optimizing genotype compositions for common tasks and (2) by capturing rare specialist allele combinations, resisting cliff-edge ecological catastrophes.

Significance statement
Polyandry is a female’s practice of mating with several males, storing their sperm, and using it to produce one or more clutches of genetically diverse offspring. In the social Hymenoptera, polyandry increases the genetic diversity and task efficiency of workers, leading to improved colony fitness. Over 90% of the increase in a colony’s diversity potential is achieved by its mother’s tenth mating; however, many females practice hyperpolyandry, a term we reserve here for mating levels above this genetic diversity asymptote. We show that a token of colony fitness arising from common tasks, brood survival, improves universally as one moves from sub- to hyperpolyandrous mating levels. However, a colony phenotype arising from a rare parasite resistance task is only expressed in the presence of the controlling alleles and under conditions of hyperpolyandry. These results suggest adaptive mechanisms by which hyperpolyandry could evolve.
Biomechanical stability of complex coronal plane fracture fixation of the capitellum
Authors: Borbas Paul , Loucas Rafael , Loucas Marios , Vetter Maximilian , Hofstede Simon , Ernstbrunner Lukas , Wieser Karl 
Published: August 2021

Abstract
Introduction
Coronal plane fractures of the distal humerus are relatively rare and can be challenging to treat due to their complexity and intra-articular nature. There is no gold standard for surgical management of these complex fractures. The purpose of this study was to compare the biomechanical stability and strength of two different internal fixation techniques for complex coronal plane fractures of the capitellum with posterior comminution.

Materials and methods
Fourteen fresh frozen, age- and gender-matched cadaveric elbows were 3D-navigated osteotomized simulating a Dubberley type IIB fracture. Specimens were randomized into one of two treatment groups and stabilized with an anterior antiglide plate with additional anteroposterior cannulated headless compression screws (group antiGP + HCS) or a posterolateral distal humerus locking plate with lateral extension (group PLP). Cyclic testing was performed with 75 N over 2000 cycles and ultimately until construct failure. Data were analyzed for displacement, construct stiffness, and ultimate load to failure.

Results
There was no significant difference in displacement during 2000 cycles (p = 0.291), stiffness (310 vs. 347 N/mm; p = 0.612) or ultimate load to failure (649 ± 351 vs. 887 ± 187 N; p = 0.140) between the two groups.

Conclusions
Posterolateral distal humerus locking plate achieves equal biomechanical fixation strength as an anterior antiglide plate with additional anteroposterior cannulated headless compression screws for fracture fixation of complex coronal plane fractures of the capitellum. These results support the use of a posterolateral distal humerus locking plate considering the clinical advantages of less invasive surgery and extraarticular metalware.

Level of evidence
Biomechanical study.
From GPS to semantic data: how and why—a framework for enriching smartphone trajectories
Authors: Ibrahim Ahmed , Zhang Heng , Clinch Sarah , Harper Simon 
Published: August 2021

AbstractDeriving human behaviour from smartphone location data is a multitask enrichment process that can be of value in behavioural studies. Optimising the algorithmic details of the enrichment tasks has shaped the current advances in the literature. However, the lack of a processing framework built around those advances complicates the planning for implementing the enrichment. This work fulfils the need for a holistic and integrative view that comprehends smartphone-specific requirements and challenges to help researchers plan the implementation. We propose a structural framework from a systematic literature review conducted to pinpoint the main challenges and requirements of research on enriching location data. We classify findings based on the enrichment task and integrate them accordingly into workflows that facilitate the task’s implementation. These workflows help researchers better streamline their implementations of the enrichment process and analyse errors within and across tasks. Moreover, researchers can integrate the presented findings with the proposed opportunities to better predict the impact of their research.
Associations of age, sex, sexual abuse, and genotype with monoamine oxidase a gene methylation
Authors: Checknita David , Tiihonen Jari , Hodgins Sheilagh , Nilsson Kent W. 
Published: August 2021

AbstractEpigenome-wide studies report higher methylation among women than men with decreasing levels with age. Little is known about associations of sex and age with methylation of monoamine oxidase A (MAOA). Methylation of the first exonic and partial first intronic region of MAOA has been shown to strengthen associations of interactions of MAOA-uVNTR genotypes and adversity with aggression and substance misuse. Our study examined associations of sex and age with MAOA first exon and intron methylation levels in 252 women and 157 men aged 14–73 years. Participants included adolescents recruited at a substance misuse clinic, their siblings and parents, and healthy women. Women showed ~ 50% higher levels of exonic, and ~ 15% higher intronic, methylation than men. Methylation levels were similar between younger (M = 22.7 years) and older (M = 46.1 years) participants, and stable across age. Age modified few associations of methylation levels with sex. MAOA genotypes modified few associations of methylation with sex and age. Higher methylation levels among women were not explained by genotype, nor interaction of genotype and sexual abuse. Findings were similar after adjusting for lifetime diagnoses of substance dependence (women = 24.3%; men = 34.2%). Methylation levels were higher among women who experienced sexual abuse than women who did not. Results extend on prior studies by showing that women display higher levels of methylation than men within first intronic/exonic regions of MAOA, which did not decrease with age in either sex. Findings were not conditioned by genotype nor interactions of genotype and trauma, and indicate X-chromosome inactivation.
Long term outcome and elasticity of a polyester mesh used for laparoscopic ventral hernia repair
Authors: O’Dwyer P. J. , Chew C. , Qandeel H. 
Published: August 2021

Abstract
Background
Repair of a ventral hernia is increasingly being performed by a laparoscopic approach despite lack of good long term follow up data on outcomes. The aim of this study was to examine the long term performance of a polyester mesh and to assess its elastic properties in patients undergoing laparoscopic ventral hernia repair.

Methods
All patients being assessed for a ventral hernia repair between August 2011 and November 2013 were placed on a prospective database. Those undergoing laparoscopic repair with a polyester mesh were seen at clinic at one month and one year, while their electronic records were assessed at 34 months (range 24–48 months) and 104 months (range 92–116 months). In addition, CT scans of the abdomen and pelvis performed for any reason on these patients during the follow up period were reviewed by a consultant gastrointestinal radiologist. Mechanical failure testing of the mesh was also performed.

Results
Thirty-two of the 100 patients assessed for ventral hernia repair had a laparoscopic repair with a polyester mesh. Nineteen (59%) had CT scans performed during the follow-up period. No recurrence was recorded at 34 months, while three (9.4%) had a recurrence at 104 months. Two had central breakdown of the mesh at 81 and 90 months, while 1 presented acutely at 116 months after operation. Mesh had stretched across the defect by an average of 21% (range 5.7–40%) in nine patients. Mechanical testing showed that this mesh lost its elasticity at low forces ranging between 1.8 and 3.2 N/cm.

Conclusion
This study shows that late recurrence is a problem following laparoscopic ventral hernia repair with polyester mesh. The mesh loses it elasticity at a low force. This combined with degradation of mesh seems the most likely cause of failure. This is unlikely to be a unique problem of polyester mesh and further long-term studies are required to better assess this operative approach to ventral hernia repair.
Runtime translation of OCL-like statements on Simulink models: Expanding domains and optimising queries
Authors: Sanchez Beatriz A. , Zolotas Athanasios , Hoyos Rodriguez Horacio , Kolovos Dimitris , Paige Richard F. , Cooper Justin C. , Hampson Jason 
Published: August 2021

AbstractOpen-source model management frameworks such as OCL and ATL tend to focus on manipulating models built atop the Eclipse Modelling Framework (EMF), a de facto standard for domain specific modelling. MATLAB Simulink is a widely used proprietary modelling framework for dynamic systems that is built atop an entirely different technical stack to EMF. To leverage the facilities of open-source model management frameworks with Simulink models, these can be transformed into an EMF-compatible representation. Downsides of this approach include the synchronisation of the native Simulink model and its EMF representation as they evolve; the completeness of the EMF representation, and the transformation cost which can be crippling for large Simulink models. We propose an alternative approach to bridge Simulink models with open-source model management frameworks that uses an “on-the-fly” translation of model management constructs into MATLAB statements. Our approach does not require an EMF representation and can mitigate the cost of the upfront transformation on large models. To evaluate both approaches we measure the performance of a model validation process with Epsilon (a model management framework) on a sample of large Simulink models available on GitHub. Our previous results suggest that, with our approach, the total validation time can be reduced by up to 80%. In this paper, we expand our approach to support the management of Simulink requirements and dictionaries, and we improve the approach to perform queries on collections of model elements more efficiently. We demonstrate the use of the Simulink requirements and dictionaries with a case study and we evaluate the optimisations on collection queries with an experiment that compares the performance of a set of queries on models with different sizes. Our results suggest an improvement by up to 99% on some queries.
Individual and Relationship-Level Correlates of Transactional Sex Among Adolescent Girls and Young Women in Malawi: A Multilevel Analysis
Authors: Gichane Margaret W. , Rosenberg Nora E. , Zimmer Catherine , Pettifor Audrey E. , Maman Suzanne , Maseko Bertha , Moracco Kathryn E. 
Published: August 2021

AbstractTransactional sex increases HIV risk among adolescent girls and young women (AGYW). Understanding the individual and dyadic nature of transactional sex may provide evidence for risk reduction interventions. Multilevel logistic regression was used to cross-sectionally examine correlates of transactional sex among AGYW in Lilongwe, Malawi. Participants (N = 920) reported 1227 relationships. Individual-level associations were found between being divorced/widowed (AOR 5.07, 95% CI 1.93, 13.25), married (AOR 0.26, 95% CI 0.09, 0.72), or unstably housed (AOR 7.11, 95% CI 2.74, 18.47) and transactional sex. At the relationship-level, transactional sex occurred in relationships with: non-primary primary partners (AOR 4.06, 95% CI 2.37, 6.94), perceived partner concurrency (AOR 1.85, 95% CI 1.11, 3.08), and feared violence with couples HIV testing (AOR 2.81, 95% CI 1.26, 6.29), and less likely to occur in relationships with children (AOR 0.15, 95% CI 0.06, 0.38). Multiple co-occurring social and structural vulnerabilities increase transactional sex engagement warranting the need for social protection and gender transformative approaches.
The phosphorylated pathway of serine biosynthesis is crucial for indolic glucosinolate biosynthesis and plant growth promotion conferred by the root endophyte Colletotrichum tofieldiae
Authors: Zimmermann Sandra E. , Blau Samira , Frerigmann Henning , Krueger Stephan 
Published: August 2021

Abstract
Key message
Phosphoglycerate Dehydrogenase 1 of the phosphorylated pathway of serine biosynthesis, active in heterotrophic plastids, is required for the synthesis of serine to enable plant growth at high rates of indolic glucosinolate biosynthesis.

Abstract
Plants have evolved effective strategies to defend against various types of pathogens. The synthesis of a multitude of specialized metabolites represents one effective approach to keep plant attackers in check. The synthesis of those defense compounds is cost intensive and requires extensive interaction with primary metabolism. However, how primary metabolism is adjusted to fulfill the requirements of specialized metabolism is still not completely resolved. Here, we studied the role of the phosphorylated pathway of serine biosynthesis (PPSB) for the synthesis of glucosinolates, the main class of defensive compounds in the model plant Arabidopsis thaliana. We show that major genes of the PPSB are co-expressed with genes required for the synthesis of tryptophan, the unique precursor for the formation of indolic glucosinolates (IG). Transcriptional and metabolic characterization of loss-of-function and dominant mutants of ALTERED TRYPTOPHAN1-like transcription factors revealed demand driven activation of PPSB genes by major regulators of IG biosynthesis. Trans-activation of PPSB promoters by ATR1/MYB34 transcription factor in cultured root cells confirmed this finding. The content of IGs were significantly reduced in plants compromised in the PPSB and these plants showed higher sensitivity against treatment with 5-methyl-tryptophan, a characteristic behavior of mutants impaired in IG biosynthesis. We further found that serine produced by the PPSB is required to enable plant growth under conditions of high demand for IG. In addition, PPSB-deficient plants lack the growth promoting effect resulting from interaction with the beneficial root-colonizing fungus Colletotrichum tofieldiae.