bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growing theory for practice: empirical multimodality beyond the case study
Authors: Bateman John A. 
Published: September 2021

Abstract
Many studies investigating the use and effectiveness of multimodal communication are now confronting the need to engage with larger bodies of data in order to achieve more empirically robust accounts, moving beyond the earlier prevalence of small-scale ‘case studies’. In this article, I briefly characterise how recent developments in the theory of multimodality can be drawn upon to encourage and support this change in both scale and breadth. In particular, the contribution will show how refinements in the degree of formality of definitions of the core multimodal constructs of ‘semiotic mode’ and ‘materiality’ can help bridge the gap between exploratory investigations of complex multimodal practices and larger-scale corpus studies.
High-performance flexible surface-enhanced Raman scattering substrate based on the particle-in-multiscale 3D structure
Authors: Zhou Yaning , Yao Haizi , Liu Chundong , Chen Mengyu , Zhang Chao , Liu Mei , Wang Jian , Fujun Zhang  , Yu Jing , Man Baoyuan , Sun Qianqian 
Published: September 2021

Abstract
Recently, multiscale three-dimensional (3D) structures consisting of micrometer-scale structure and nanometer-scale structure have received some attention from scientists in the field of surface-enhanced Raman scattering (SERS). In this work, micrometer-scale grating structure and nanometer-scale zinc oxide nano spikes (ZnO NSs) structure are successfully introduced into the SERS substrate with silver nanoparticles (Ag NPs) as the surface plasmon. The optimized particle-in-multiscale 3D substrate (PDMS/grating/ZnO NSs/Ag NPs) presents high sensitivity with an ultralow limit of detection of 1 × 10−11 M and a high enhancement factor of 7.0 × 108 for Rhodamine 6G (R6G) as the probe molecule. It benefits from the electromagnetic field enhancement from the excellent optical capture capability of grating/ZnO NSs structure and abundant electromagnetic hot spots. The quantitative analysis ability of the SERS substrate can be indicated from the good linear correlation between the logarithmic Raman intensity and the molecular concentration. At the same time, this SERS substrate exhibits excellent homogeneity and reproducibility, which have low relative standard deviations (4.43%) of the Raman intensities at 613 cm−1 peaks for R6G as the probe molecule. In addition, this SERS substrate can realize in-situ detection of Raman signal due to its excellent light transmission and flexibility. The particle-in-multiscale 3D structure as SERS substrate exhibits the vast potential in practical applicability for qualitatively and quantitatively chemical and biomedical analysis.
Femtosecond laser micromachining for integrated quantum photonics
Authors: Corrielli Giacomo , Crespi Andrea , Osellame Roberto 
Published: September 2021

Abstract
Integrated quantum photonics, i.e. the generation, manipulation, and detection of quantum states of light in integrated photonic chips, is revolutionizing the field of quantum information in all applications, from communications to computing. Although many different platforms are being currently developed, from silicon photonics to lithium niobate photonic circuits, none of them has shown the versatility of femtosecond laser micromachining (FLM) in producing all the components of a complete quantum system, encompassing quantum sources, reconfigurable state manipulation, quantum memories, and detection. It is in fact evident that FLM has been a key enabling tool in the first-time demonstration of many quantum devices and functionalities. Although FLM cannot achieve the same level of miniaturization of other platforms, it still has many unique advantages for integrated quantum photonics. In particular, in the last five years, FLM has greatly expanded its range of quantum applications with several scientific breakthroughs achieved. For these reasons, we believe that a review article on this topic is very timely and could further promote the development of this field by convincing end-users of the great potentials of this technological platform and by stimulating more research groups in FLM to direct their efforts to the exciting field of quantum technologies.
On motivation and incoordination in grammar – The case of two Polish exclamative constructions
Authors: Bierwiaczonek Bogusław 
Published: September 2021

AbstractThe paper discusses two Polish exclamative constructions as instances of the Abstract Exclamative Construction (AEC) proposed by Michaelis and Lambrecht (1996). It is argued that while theCo-zaExclamative Construction is motivated straightforwardly by the identifyingCo-zaQuestion Construction as well as AEC, theAleExclamative Construction involves not only AEC but also a more complex process called “incoordination”, whereby a second coordinate clause with its coordinating conjunctionalebecomes an autonomous monoclausal construction. The process involves a change in the information structure and in illocutionary force, which becomes increasingly expressive. In addition, it is accompanied by a shift of the sentence stress from the focal element in the second coordinate clause to the initialAle.
Altered Cerebellar Response to Somatosensory Stimuli in theCntnap2Mouse Model of Autism
Authors: Fernández Marta , Sánchez-León Carlos A. , Llorente Javier , Sierra-Arregui Teresa , Knafo Shira , Márquez-Ruiz Javier , Peñagarikano Olga 
Published: September 2021

AbstractAtypical sensory processing is currently included within the diagnostic criteria of autism. The cerebellum is known to integrate sensory inputs of different modalities through its connectivity to the cerebral cortex. Interestingly, cerebellar malformations are among the most replicated features found in postmortem brain of individuals with autism. We studied sensory processing in the cerebellum in a mouse model of autism, knock-out (KO) for theCntnap2gene.Cntnap2is widely expressed in Purkinje cells (PCs) and has been recently reported to regulate their morphology. Further, individuals withCNTNAP2mutations display cerebellar malformations and CNTNAP2 antibodies are associated with a mild form of cerebellar ataxia. Previous studies in theCntnap2mouse model show an altered cerebellar sensory learning. However, a physiological analysis of cerebellar function has not been performed yet. We studied sensory evoked potentials in cerebellar Crus I/II region on electrical stimulation of the whisker pad in alert mice and found striking differences between wild-type andCntnap2KO mice. In addition, single-cell recordings identified alterations in both sensory-evoked and spontaneous firing patterns of PCs. These changes were accompanied by altered intrinsic properties and morphologic features of these neurons. Together, these results indicate that theCntnap2mouse model could provide novel insight into the pathophysiological mechanisms of autism core sensory deficits.
Alpha Oscillations Shape Sensory Representation and Perceptual Sensitivity
Authors: Zhou Ying Joey , Iemi Luca , Schoffelen Jan-Mathijs , de Lange Floris P. , Haegens Saskia 
Published: September 2021

Alpha activity (8–14 Hz) is the dominant rhythm in the awake brain and is thought to play an important role in setting the internal state of the brain. Previous work has associated states of decreased alpha power with enhanced neural excitability. However, evidence is mixed on whether and how such excitability enhancement modulates sensory signals of interest versus noise differently, and what, if any, are the consequences for subsequent perception. Here, human subjects (male and female) performed a visual detection task in which we manipulated their decision criteria in a blockwise manner. Although our manipulation led to substantial criterion shifts, these shifts were not reflected in prestimulus alpha band changes. Rather, lower prestimulus alpha power in occipital-parietal areas improved perceptual sensitivity and enhanced information content decodable from neural activity patterns. Additionally, oscillatory alpha phase immediately before stimulus presentation modulated accuracy. Together, our results suggest that alpha band dynamics modulate sensory signals of interest more strongly than noise.SIGNIFICANCE STATEMENTThe internal state of our brain fluctuates, giving rise to variability in perception and action. Neural oscillations, most prominently in the alpha band, have been suggested to play a role in setting this internal state. Here, we show that ongoing alpha band activity in occipital-parietal regions predicts the quality of visual information decodable in neural activity patterns and subsequently the human observer's sensitivity in a visual detection task. Our results provide comprehensive evidence that visual representation is modulated by ongoing alpha band activity and advance our understanding on how, when faced with unchanging external stimuli, internal neural fluctuations influence perception and behavior.
Heart rate variability and interoceptive accuracy predict impaired decision-making in Gambling Disorder
Authors: Moccia Lorenzo , Quintigliano Maria , Janiri Delfina , De Martin Valentina , Rogier Guyonne , Sani Gabriele , Janiri Luigi , Velotti Patrizia , Gallese Vittorio , Speranza Anna Maria , Di Nicola Marco 
Published: September 2021

Abstract

Background and aims
Gambling Disorder (GD) entails maladaptive patterns of decision-making. Neurophysiological research points out the effect of parasympathetic arousal, including phasic changes in heart rate variability (HRV), and interoceptive accuracy (IA, i.e., the ability to track changes in bodily signals), on decision-making. Nevertheless, scarce evidence is available on their role in GD. This is the first study exploring the impact in GD of respiratory sinus arrhythmia (RSA), an index of HRV, and IA on decision-making, as measured by the Iowa Gambling Task (IGT).

Methods
Twenty-two patients experiencing problems with slot-machines or video lottery terminals gambling and 22 gender- and age-matched healthy controls (HC) were recruited. A resting ECG was performed before and after the completion of the IGT. IA was assessed throughout the heartbeat detection task. We conducted a MANCOVA to detect the presence of significant differences between groups in RSA reactivity and IA. A linear regression model was adopted to test the effect of factors of interest on IGT scores.

Results
Patients with GD displayed significantly decreased RSA reactivity (P = 0.002) and IA (P = 0.024) compared to HCs, even after controlling for affective symptoms, age, smoking status, and BMI. According to the linear regression model, cardiac vagal reactivity and IA significantly predict decision-making impairments on the IGT (P = 0.008; P = 0.019).

Discussion and conclusions
Although the exact pathways linking HRV and IA to impaired decision-making in GD remain to be identified, a broader exploration relying upon an embodiment-informed framework may contribute to shed further light on the clinical phenomenology of the disorder.
Application of microfluidic chips in anticancer drug screening
Authors: Fan Xin-yue , Deng Zhuo-fen , Yan Yan-yan , E. Orel Valerii , Shypko Andrii , B. Orel Valerii , Ivanova Donika , Pilarsky Christian , Tang Jing , Chen Zhe-Sheng , Zhang Jian-ye 
Published: September 2021

With the continuous development of drug screening technology, new screening methodologies and technologies are constantly emerging, driving drug screening into rapid, efficient and high-throughput development. Microfluidics is a rising star in the development of innovative approaches in drug discovery. In this article, we summarize the recent years' progress of microfluidic chip technology in drug screening, including the developmental history, structural design, and applications in different aspects of microfluidic chips on drug screening. Herein, the existing microfluidic chip screening platforms are summarized from four aspects: chip structure design, sample injection and drive system, cell culture technology on a chip, and efficient remote detection technology. Furthermore, this review discusses the application and developmental prospects of using microfluidic chips in drug screening, particularly in screening natural product anticancer drugs based on chemical properties, pharmacological effects, and drug cytotoxicity.
Using Stelfrine supra 2.5% for children with accommodation and refraction disabilities
Authors: Pekerskaya Valeria L. , Zhuravleva Ekaterina V. 
Published: September 2021

AIM:To assess the effect of Stelfrin supra (phenylephrine 2.5%) on the condition of accommodation, refraction and evaluate subjective comfort in instillation and adolescents with various refractive disorders.
MATERIALS AND METHODS:Examined 45 people with mild emmetropia and hyperopia with symptoms of habitual excess tension of accommodation (15 people), with mild myopia (15 people), with moderate myopia (15 people) at the age of 7 to 16 years. Visometry, autorefractometry, assessment of the volume of absolute accommodation (positive and negative parts), subjective assessment of asthenopic complaints according to the OSDI scale were carried out before and 1 month after daily instillations of Stelfrin supra (phenylephrine 2.5%).
RESULTS:After 1 month of instillation of the Stelfrin supra, the manifestations of accommodative asthenopia in the vast majority of patients in the study groups decreased, the habitual tonus of accommodation decreased, the volume of absolute accommodation increased, most significantly its negative part. The uncorrected visual acuity increased by 31% in patients of group 1 with emmetropia and mild hyperopia with habitually excessive tension of accommodation. The uncorrected visual acuity increased by 23% in patients of group 2 with mild myopia. An increase in the margin of relative accommodation was noted in patients of groups 1 and 2. Instillation of the drug was not accompanied by severe discomfort in the vast majority of patients.
CONCLUSIONS:Stelfrin supra has shown its effectiveness in accommodating and refractive disorders in childhood and can be recommended in the treatment of children with accommodation disorders, asthenopia and mild to moderate myopia.
Effectiveness of eye-light therapy in improving dry eye symptoms
Authors: Pirdankar Onkar H , Kenia Vaishal P , Saldanha Merlin , Kenia Raj V 
Published: September 2021

: We aimed to examine the effectiveness of eye-light therapy in improving the dry eye symptoms.: The retrospective case series where patients who underwent eye-light therapy between March 2019 to May 2020 were analyzed. Twenty patients aged ≥18 years with dry eyes were included. Patients with ocular infections, complications, contact lens users and missing data were excluded. OSDI scores and tear parameters such as noninvasive break up time (NIBUT), lipid layer thickness (LLT), tear meniscus height, meibography of upper and lower lid were evaluated pre and post one month Eye-Light therapy.: Twenty patients with mean±SD age of 43.55±20.53 years and mean spherical equivalent refractive error of 0.69±1.79 diopters were analyzed. OSDI was significantly associated with NBUT (r=-0.50, P = 0.02), lipid layer thickness (r=-0.45, P=0.047) and tear height (r =-0.45, P=0.046). OSDI was positively associated with upper lid meibography (r=0.74, P=&#60;0.001) and lower lid meibography (r=0.45, P=0.045). Post-therapy, reduction in OSDI score post-therapy was present, NBUT was similar, lipid layer thickness and tear height were increased, meibography of upper lid was reduced, and meibography of lower lid did not alter much. Eye-light therapy is effective in reducing dry eye related symptoms with minimal immediate effect on tear film parameters post therapy. Eye-light therapy acts as an adjunct to ameliorate MGD. MGD being a chronic disease requires sustained therapy with environmental changes. Long term evaluation is required to assess the tear film changes and the pattern of efficacy of light therapy.
Study of retinal nerve fiber layer thickness in chronic kidney disease patients
Authors: Singh Shivangi , Dhasmana Renu , Verma Neelam , Ahmad Shahbaj 
Published: September 2021

To compare the RNFL thickness between CKD patients and age matched healthy controls and to correlate RNFL thickness with duration of CKD. RNFL thickness was also assessed in CKD patients with and without haemodialysis.: One hundred and fifty eyes were included in the study and were labeled as group A. Equal number of age matched controls were included in group B. RNFL thickness was measured using optical coherence tomography for optic nerve head (ONH) scan.Mean of average RNFL thickness was studied to be thinner in group A in comparison to group B. Statistically significant thinning was also noted in superior and inferior quadrant of group A. Increase in average RNFL thickness and increase in superior and temporal quadrant RNFL thickness was noted in HD group as compared to non- HD group. A negative correlation was noted between RNFL thickness and duration of CKD. : This study concluded that RNFL thickness was found to be thinner in CKD patients as compared to healthy individuals. However RNFL thickness was found to be thicker in HD group as compared to non- HD group.
A study to compare intraocular pressure using Perkins and Schiotz tonometer with respect to Goldmann applanation tonometer as a gold standard in a tertiary health care centre, Navi Mumbai
Authors: Agrawal Mamta , Ramakrishnan Reshma , Kalapad Suvarna , Shrivastava Saurabh , Gandhi Priyanka 
Published: September 2021

To compare IOP measurement of Perkin’s tonometer and Schiotz tonometer with respect to Goldmann applanation tonometer (GAT).100 eyes of 50 patients aged 18 to 65 years presenting to Ophthalmology OPD were selected by randomization and detailed general and ophthalmic examination was done. IOP was measured using applanation tonometers (Perkin’s and GAT) and indentation tonometer (Schiotz tonometer) in that order. The study population included 38 male eyes and 62 female eyes; 50 right eyes and 50 left eyes. There was a statistically highly significant difference seen for the values between the groups (p&#60;0.01) with higher values in IOP measured by GAT followed by IOP measured by Perkin’s tonometer and least in IOP measured by Schiotz tonometer.There was a statistically non significant difference seen for the values between Perkin’s tonometer and GAT (p&#62;0.05). While there was a statistically highly significant difference seen for the values between GAT and Schiotz tonometer (p&#60;0.01).There was a statistically non significant difference seen for the IOP values between right eye and left eye. There was a statistically non significant difference seen for the IOP values between males and females. Measurement of IOP with Perkin’s was closer to the values obtained by GAT. Perkin’s being portable, easy to use and precise tonometer than Schiotz tonometer, can be considered as an excellent substitute to GAT, for large scale examination, if cost is not a concern.
A comparative study of central corneal thickness in diabetics and non-diabetics using ultrasonic pachymetry
Authors: Reddy Chinnangolla Viveknandini , Reddy M H 
Published: September 2021

To determine association between central corneal thickness and type 2 diabetes mellitus in patients attending outpatient department of Ophthalmology at a tertiary care centre in North Karnataka.This is a cross-sectional study conducted over a period of April 2018 – September 2020 on patients attending outpatient department of Ophthalmology at a tertiary care centre in North Karnataka. Study includes 168 subjects divided into 3 groups: 40 diabetics whose duration &#62;10 years46 diabetics whose duration ≤10 yearsand 82 controls.Detailed ophthalmic examination was conducted in all patients and central corneal thickness was measured using ultrasound pachymetry.A statistically significant difference was found between mean central corneal thickness of diabetics (534.0581µ - right eye; 534.3605µ - left eye) and non-diabetics (525.8659µ - right eye; 525.8659µ - left eye); p value &#60;0.05. Association between central corneal thickness and age, gender, laterality and duration of diabetes were not statistically significant.Patients with type 2 diabetes mellitus have thicker corneas as compared to non-diabetics. Henceforth, it is important to measure central corneal thickness in all diabetics, as it affects IOP measurement which is vital for early diagnosis and timely treatment of glaucoma.
Reseña y crítica a la obra: Ciencia y política en Karl Popper. Más nueve ensayos sobre otros temas de su obra de Blanca Inés Prada Márquez
Authors: Esparza-Oviedo Silvia María 
Published: September 2021

Reseña del libro Ciencia y política en Karl Popper. Más nueve ensayos sobre otros temas de su obra. Blanca Inés Prada Márquez (2018). Windmills Editions. 366 pp.
GLOBÁLIS TUDÁSBÁZIS SZEMANTIKUS WEB ALAPOKON
Authors: Roskó Tibor 
Published: September 2021

A tanulmány témája egy olyan globálisan elérhető központi tudásbázis kialakítása, mely a jövőben agyba épített interfésszel bárki által online elérhető, kereshető. Ennek részletes bemutatása a cél, mely a téma felvezetésével, annak társadalmi oldaláról vett elemzésével kezdődik. Ezt követően az idők kezdetétől napjainkig bemutatásra kerül, hogyan fejlődött, alakult ki a ma ismert formája. A tanulmány végén pedig két megközelítésből kerül elemzésre: legpesszimistább és legoptimistább verzió, milyen bekövetkezési esélyekkel, illetve milyen tényezők vezethetnek el a bekövetkezésükhöz. Bízunk benne, a tanulmány hozzájárul a legoptimistább verzió elkövetkező években történő megvalósításához. Jelen tanulmány a Debreceni Egyetem Tehetséggondozó Program „Időkapszula 2016+20” projekt keretében készült; projektvezető: Dr. Mező Ferenc.
HÁTRÁNYOS HELYZETŰ GYEREKEK REKRUTÁCIÓJA, JÖVŐKÉPE
Authors: Erdei Ildikó 
Published: September 2021

Magyarországon számos nevelésbe vett gyermek él. Ahhoz, hogy ennek társadalmi újratermelődését megfékezzük, fontos látnunk a rekrutációt: kik ők, honnan és miért kerültek szakellátásba? Foglalkozni kell a fiatalok jövőképével, motivációjával, én-hatékonyságával, sikerre vonatkozó ok-tulajdonításával, társadalmi beilleszkedésével, az ezekről alkotott elképzelésükkel. Jelen publikáció célja feltárni a különbségeket a lakásotthonban élő és családban nevelkedő hátrányos helyzetű fiatalok jövőorientációjára vonatkozóan. Mindezt a tanulmányi átlag elemzésével, jövőképre vonatkozó kérdőív, családi háttér feltárására szolgáló önkitöltős kérdőív, valamint a Tenessee énkép skála használatával tettük mérhetővé. A vizsgálatban 60 fő lakásotthonban élő gyermek és fiatal, valamint 60 fő családban élő gyermek és fiatal felnőtt vett részt. Mindkét csoport 1999-2004 között született 15-20 éves fiatalokból áll. A kutatás célja, a lakásotthonban élő hátrányos helyzetű gyerekek jövő-orientációjának megismerése szintén hátrányos helyzetű Arany János Tehetséggondozó Programban tanuló, de családban élő gyerekek közötti különbség, vagy hasonlóság terén. A statisztikai elemzés során megállapítást nyert, hogy a Jövőképre vonatkozó kérdőív és a Háttér kérdőív között pozitív korreláció áll fenn. A két kérdőívben szereplő kérdések nagy része összefügg.