bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of UTAUT 2 Model on the Use of BCA Mobile Banking in Indonesia
Authors: Et. al. Aniek Susilowati 
Published: April 2021

The m-banking service is a long-distance transaction platform that is innovative and strategic product provided by financial institution. It has succeeded in removing physical limitation of banking activities through the use of mobile device by customers. Support for the advance in internet technology bringing about considerable and continuous changes in banking operational have enabled customers to connect with business world and make transaction at any time, so that it also changes how customers use banking services. The World’s Best Bank has positioned BCA as a bank capable of adapting to pandemic situation because its banking services related to technology is considered as the best. Therefore, this research recognizes the need for testing factors affecting BCA customers to adopt and continue to use BCA m-banking service.
Design/methodology/approach – the conceptual relationship of behavior intention on the acceptance and the use of information technology in this research used UTAUT2 model. Primary data were processed using SEM method with SMART-PLS software collected from survey questionnaires carried out to 400 respondents having BCA accounts and using BCA m-banking in the last 3 months.
Findings – the main factors such as habit, hedonic motivation and facilitating condition were found to provide significant effect on behavior intention of customers to adopt and use BCA m-banking service.
Practical implications – the findings are expected to educate public about m-banking service capable of facilitating banking transaction and recommending banking system to provide a safe m-banking service and it also requires sustainable development.
A review on prediction of diabetes type 2 by machine learning techniques
Authors: Singh Alka 
Published: April 2021

Machine learning is considered to be one of the most promising tools when it comes to working with heterogeneous data. It provides a new dimension which enables one to extract relevant data and take decision for the effective functioning of the network, making use of network generated data. Every sphere of our life is now dependent on machine learning. It has flourished in every dimension. Making it versatile and ever demanding.
Department of healthcare contains very abundant and sensitive information which is needed to be carefully handled. Diabetes mellitus is increasing exponentially and is spreading like anything in the world. A reliable prediction system should be present for diagnosing diabetes. Variety of machine learning techniques find their use in the examination of data from variant perspectives and summarizing it into effective information. Usage of new patterns is done to elucidate these patterns in order to deliver relevant information for their users. By making use of techniques such as SVM, random forest, logistic regression, naïve bayes etc the prediction of diabetes can be done easily and accurately. In this study we will make use of different machine learning techniques and try to find accurate prediction regarding the same.
The Performance of Internal Shariah Auditor in Islamic Financial Institutions
Authors: Et.al Azam Abdelhakeem Khalid 
Published: April 2021

Purpose –It is this study’s objective to examine the correlations between internal Shariah auditors’ independence, qualifications and performance in Islamic financial institutions (IFIs), conceptually.
Design/methodology/approach – This paper is theoretical in its approach; whereby it also undertakes an extensive literature review. From a general agency theory, an Islamic agency theory is articulated and applied to ascertain the attributes of internal Shariah auditor performance revolving around the concept of independence and qualifications.
Findings – Performance of internal Shariahauditing, as a mechanism of assuring Shariahcompliance by IFIs varies directly with the degree of independence and qualifications enjoyed by internal Shariah auditors themselves. The study finds that in evaluating the freedom and qualifications of FIs’internalShariah auditors, Islamic agency theory can potentially serve as the theoretical foundation in developing a multi-dimensional conceptual framework.
Research Limitations/implications – Evidence is drawn strictly from secondary sources.
Practical implications –To ensure that internal Shariahauditor is effectively performing, IFIs ought to improve the degree of independence and qualifications of their auditors.
Originality/value –The studies on the performance of internal and external Shariahauditorsin conventional financial institutions have been extensively researched. However, research on the performance of IFIs’ internal Shariah audit is yet to be conducted extensively.
Moderation Effect of Supervisor Support between Flexible Working Arrangement andWork-Family Conflict in Malaysia
Authors: Et.al Eni Suriana Binti Alias 
Published: April 2021

There have been major changes in current workforce competitiveness trends. The changes in workforce demographics particularly in the increase of dual-earner families and single-parents have resulted in increased multiple role conflicts. Working couples must cope with the problem of combining work and family responsibilities in their daily life. Many industries adopted the current trend of the flexible working environment into their organizations. This study explores the moderation effect of supervisor support between flexible working arrangements (FWA), the effect on work interference with family conflict (WIF) and family interference with work (FIW). The population for this study primarily focused on the organizations that adopt the flexible working arrangement such as flexible working time, working from home, and compressed work-week practices in Malaysia. The companies selected is based on the listing of global organizations practices FWA mentioned in Talent Corp Malaysia Flexible Working Arrangement collaboration with Malaysian Federation Employer report, 2015. The questionnaires were distributed through the Human Resource Department of each organization. The result demonstrated that there is relationship between FWA and WIF and there was moderation effect of supervisor support (SS) between FWA and WIF. However, the result showed no moderation effect of SS between FWA and FIW. This study supports the idea that supervisor support is a resource that helps employees to manage the occurrence of interference from work to family and to overcoming FIW, supports particularly from family members either siblings, parents and spouse is important. The implication of this study is that, work conflict issue requires the proactive effort and support not only from the organization in terms of supervisor support through FWA but also support within the family circle. Organizations approach in adopting FWA in their attempts to minimize WFC is recommendable but it should be applied across occupation and organizations as one of employee benefits policy.
Accounting Treatment for Ijarah and Ijarah MuntahiaBittamleek in Sudanese Islamic Banks
Authors: Et.al Azam Abdelhakeem Khalid 
Published: April 2021

Purpose – This paper aims to review and analyze the concept of Ijarah and Ijarah MuntahiaBittamleek (IMB)in Sudanese Islamic banks.
Design/methodology/approach-The researchers followed descriptive analytical methodology and Inductive method in conducting this study as well as the comparative method to compare FAS No.8 to IAS 17 concerning the accounting treatments. Also,the applied method was used for the practical side of the study based upon the financial reports in the Sudanese Islamic banks.
Findings -The study found that the main difference between two standards is that FAS No.8 focuses on the legal aspect of the financial transactions while IAS 17 focuses on theaspect of economy.The study also found that the Sudanese Islamic Banks were committed to apply FAS No.8 in regard to accounting measurement, but were not committed to apply FAS No.8 in regard to recognition, presentation and disclosure in the financial reports.
Practical implication – The paper contributes to the Sudanese Islamic Banks to apply the FAS No.8 with regard to recognition and accounting disclosure.
Originality/value –This research is the pioneerin analyzing the concept of Ijarah and Ijarah MuntahiaBittamleek (IMB) in Sudanese Islamic banks.
Determination of Suitable Candidate Genes as Endogenous Control for Gene Expression Analysis in Local Capsicum Annuum MC11
Authors: Et.al Marina Mokhtar 
Published: April 2021

Quantitative real-time polymerase chain reaction (qRT-PCR) is one of the most common methods for gene expression studies. Data normalization based on reference genes is essential for qRT-PCR assays. This study identifies suitable reference genes for local chilli, Capsicum annuum var MC11 under incident of Cucumber mosaic virus infection. Six candidate genes actin, tub, EF1α, GAPDH, TEF1α and 18SrRNA and three validated Capsicum reference genes UBI-3 ref, β-tub ref and gapdhref were tested against five chilli plant parts stem, shoot, leave, flower and root. The PCR/qRT-PCR results demonstrate only five candidate references genes actin, EF1α, GAPDH, 18SrRNA, and TEF1α that show specific single band of amplicon, without primer dimers and at the targeted sizes. Through qRT-PCR, GAPDH gives single peak in dissociation curve in all plant parts used further fulfilling the characteristic of reference genes.Previous work on validation of reference genes in pepper shows that only UBI-3 suits to C. annuum var MC11 infected CMV, thus we suggest that GAPDH has a potential to be a validated reference gene for C. annuum var MC11 and can be used together UBI-3 for the purpose of data normalization.
Bayesian Hierarchical Growth Model for Experimental Data on the Effectiveness of an Incentive-Based Weight Reduction Method
Authors: Et.al Md Azman Shahadan 
Published: April 2021

The objective of this current research is to model the experimental data on the effectiveness of an incentive-based weight reduction method by using Bayesian hierarchical growth models. Three Bayesian hierarchical growth models are proposed, namely parametric Bayesian hierarchical growth model with correlated intercept and slope random effects model, parametric Bayesian hierarchical growth model with no correlated intercept and slope random effects model and semi-parametric Bayesian hierarchical growth model with Dirichlet process mixture prior model. The data is obtained from forty eight (48) students who had participated in an experiment on weight reduction method. The students were divided equally into two groups: single and pair groups. The experiment was carried out over the period of three months with a weight reading session for every two weeks. At the end of the study, we had six repeated measures of each student’s weight in kg and some measures of covariates and factors. Our results showed that the best model for the above data based on the Bayesian fit indexes and the models’ flexibility is the semi-parametric Bayesian hierarchical growth model with Dirichlet process mixture prior model. The results of the semi-parametric model showed that the ‘growth’ or reduction rates of the weight reduction experiment relate to the students’ gender, height in cm, experimental group (single or pair) and time in term of weeks.
Eficiencia de un sistema combinado para la remoción de carga orgánica de efluentes
Authors: APAZA-AQUINO Hugo 
Published: April 2021

Uno de los principales residuos que se genera en la industria láctea es el lactosuero, por su alta carga orgánica representa un serio problema ambiental cuando es desechado a cuerpos naturales receptores, alterando su calidad ambiental. Se evaluó la eficiencia de un sistema combinado compuesto por laelectrocoagulación y filtro biológico; para lo cual se realizó el proceso de electrocoagulación en un reactor de régimen batch con electrodos de aluminio y hierro, el filtro biológico fue empaquetado con biomasa compuesta por: Bacillus spp, Acinetobacter spp, Lactobacillus spp y Streptococcus spp. La electrocoagulación fue el responsable de disminuir en más del 80% de la carga orgánica y el filtro biológico trabajando con una carga orgánica promedio de 1405 mg/L de DBO5 contribuyó en la disminución del remanente de la carga orgánica; el sistema combinado de electrocoagulación - filtro biológico con recirculación logró una eficiencia de remoción para la DQO del 89,7 % y para la DBO5 del 89,8 %, con un pH final de 7,37. Existen diversas tecnologías para tratar aguas residuales de la industria láctea, pero la aplicación un sistema combinado podría ser una alternativa para tratar aguas residuales lácteas por la eficiencia que se obtuvo.Palabras clave: Aguas residuales, electrocoagulación, filtro biológico, lácteo, lactosuero.
Resiliencia en estudiantes adolescentes de una institución educativa de una zona urbano-marginal durante el covid-19
Authors: CUNIAS RODRÍGUEZ Marita Yannyna , MEDINA CARDOZO Ingrid Isabel 
Published: April 2021

Esta investigación tuvo como objetivo medir el nivel de resiliencia en adolescentes de una institución educativa ubicada en una zona urbano-marginal durante la pandemia producida por el Covid 19, con el propósito de identificar los niveles de competencia emocional y de aceptación de uno mismo durante la emergencia sanitaria, mediante la aplicación de la Escala de Resiliencia de Wagnild y Youn, a 143 adolescentes. El método de investigación empleado fue el descriptivo, con un diseño no experimental. Los resultados señalan que los estudiantes son capaces de adaptarse de forma positiva ante contextos adversos, logrando desarrollar su competencia emocional; asimismo, poseen la habilidad para construir su propia identidad y aceptarse a sí mismos, factores esenciales para el desarrollo de una autoestima adecuada y cumplimiento de metas a largo plazo, por lo que disponen de recursos suficientes para afrontar su futuro.Palabras clave: resiliencia, adolescentes, Covid 19, zona urbano marginal.
The effect of age and genotype on lung function in children with cystic fibrosis
Authors: Shadrina V. V. , Voronkova A. Yu. , Starinova M. A. , Simonova O. I. , Sergienko D. F. , Semykin S. Yu. , Kashirskaya N. Yu. , Kondratyeva E. I. 
Published: April 2021

Identifying the initial manifestations of pulmonary functional disorders associated with cystic fibrosis (CF) is essential for timely correction of the therapy and improvement of the prognosis.The aim of the study was to identify the age periods with the highest risk of a decrease in lung function in children with different CF genotypes.Methods. Lung function (LF) was analyzed using spirometry results in CF patients aged 6 to 18 years from the Registry of patients with cystic fibrosis in the Russian Federation 2018.Results. The forced expiratory volume in one second (FEV1) was statistically significantly lower in children aged 6 – 10 years with “severe” genotypes than in the children with “mild” genotypes. The lung function was reduced at 11 – 14 years of age in both “severe» and “mild” genotypes without any statistically significant difference. In general, the trend of a decrease in lung function in “severe” genotypes persists in the adolescent period from 15 to 18 years. The lung function is better in adolescents aged 15 – 18 with the “mild” variants of genotypes compared to the patients aged 11 – 14 years.Conclusion. The “severe” variants of CFTR negatively affect LF of CF patients in all age groups. The LF values in patients with “mild” genotypes at the age of 15 – 18 years were higher than in children aged 11 – 14 years with the same genotypes. There is a need for improved programs of medical care for adolescents with CF.
Functional tests for assessment of residual CFTR channel activity and personalized selection of efficacious CFTR-modulators for cystic fibrosis patients with ‘mild’ and ‘severe’ genetic variants
Authors: Amelina E. L. , Efremova A. S. , Melyanovskaya Yu. L. , Bulatenko N. V. , Bukharova T. B. , Kashirskaya N. Yu. , Krasovskiy S. A. , Goldshtein D. V. 
Published: April 2021

Intestinal current measurement (ICM) and forskolin-induced swelling (FIS) assay in human intestinal organoids from rectal biopsies of cystic fibrosis (CF) patients are the new functional tests for assessment of CFTR channel activity that are widely used in the leading laboratories worldwide for scientific and clinical studies.The aim of the study was to assess the use of the new functional tests in adult CF patients with identified N1303K and R334W CFTR gene variants.Methods. Rectal suction biopsies were obtained from the two CF patients aged 36 and 27 years with N1303K/3821delT and R334W/F508del CFTR mutations, respectively. Results of the ICM and FIS assay in intestinal organoids were compared to the clinical data.Results. ICM has demonstrated that R334W is a ‘mild’ genetic variant with high residual CFTR channel activity. At the same time, N1303K is a ‘severe’ genetic variant and leads to a severe loss of CFTR channel function. These findings correlate with the clinical data. CFTR modulators compensate for the reduced activity of the R334W CFTR variant, as shown by the FIS assay. But there was a limited response of the forskolin-stimulated organoids to VX-770 potentiator and VX-809 corrector in the cells with N1303K genetic variant.Conclusion. ICM and FIS assay in human intestinal organoids are reliable methods for quantification of CFTR channel activity. They can also predict the efficacy of the targeted therapy in CF patients in vivo.
Description of rare alleles of the CFTR gene in cystic fibrosis using functional tests and forskolin-induced swelling assay in rectal organoids
Authors: Efremova A. S. , Melyanovskaya Yu. L. , Bulatenko N. V. , Odinaeva N. D. , Orlov A. V. , Pashkevich A. A. , Adyan T. A. , Kondratyeva E. I. 
Published: April 2021

Cystic fibrosis (CF) is a systemic hereditary disease caused by a mutation of the CFTR gene and characterized by damage to the glands of external secretion and severe dysfunctions of the respiratory system. The “severe” genotypes are associated with more pronounced and early clinical manifestations. The “mild” genotypes are associated with a delayed onset of clinical manifestations.Methods. An analysis of the medical history of patients with asymptomatic CF from the Russian CF centers was carried out. Rectal biopsy specimens were used for intestinal current measurement (ICM) and forskolin-induced swelling assay in intestinal organoids. DNA for sequencing was isolated from the venous blood leukocytes.Results. 2 CF patients with genotypes F508del/c.1584+18672A>G (patient 1, 12 years old) and F508del/G509D-E217G (patient 2, 3 years old) were examined. The diagnosis was based on neonatal screening. The ICM assay showed a reduced function of the CFTR channel: ΔISC for forskolin was 12.33 ± 2.35 μA/cm2 in patient 1 and 25 ± 3.37 μA/cm2 in patient 2. The negative response to carbachol and histamine reflects the entry of potassium ions into the cells, which is typical for CF. The assay in intestinal organoids showed that the amount of functional protein on the apical membrane of the intestinal epithelium increases both under the action of the potentiator and the corrector in both patients. The greatest effect is observed when the VX-770 and VX-809 are used together.Conclusion. The ICM functional assay and the forskolin-induced swelling assay in intestinal organoids are sensitive enough to determine the residual functional activity of the CFTR channel and clarify the diagnosis in difficult cases. The studied genetic variants c.1584+18672A>G and G509D-E217G belong to class IV – VI mutations. The clinical picture corresponds to the manifestations of “mild” mutations. The studied patients still attend the Russian cystic fibrosis centers.
Study of efficacy, safety, and patient satisfaction with inhaled tobramycin (Tobramycin-Gobbi) in children with cystic fibrosis and pseudomonas infection
Authors: Kondratyeva E. I. , Voronkova A. Yu. , Trishina S. V. , Snetkova N. S. , Safonova T. I. , Pavlinova E. B. , Chepurnaya M. M. , Kharakhashyan L. E. , Golubtsova O. I. , Skachkova M. A. , Kondakova Yu. A. , Enina E. A. , Vodovozova E. V. 
Published: April 2021

Study of efficacy, safety, and patient satisfaction with inhaled tobramycin (Tobramycin-Gobbi) in children with cystic fibrosis and pseudomonas infectionAim of the study was to assess efficacy and safety of Tobramycin-Gobbi in CF, as well as the patients’ satisfaction with the treatment.Methods. 35 children from 6 to 18 years with CF were enrolled in this non-interventional prospective cohort multicenter study. All children had P. aeruginosa in the respiratory tract (newly diagnosed, recurrent, or chronic infection). The children received inhalation treatment with Tobramycin-Gobbi in the following cycles: 28-day treatment/28-day break, for 6 months. The studied parameters included respiratory function, bacterial cultures of the respiratory tract with a bacterial count, growth and body weight, antibiotic therapy for the respiratory episodes. The children and parents filled in a questionnaire “Treatment satisfaction assessment” and assessed their state of health on the visual-analog scale before and after each treatment cycle.Results. P. aeruginosa was eradicated in 17.7% of cases (6 patients, including 2 newly diagnosed, 3 recurrent infections, and 1 chronic infection), reduced bacterial count, decreased number of courses of antibiotic therapy, improvement of FEV1. Adverse reactions were reported by one patient.Conclusion. The efficacy, safety, and tolerability of Tobramicine Gobbi were confirmed in the patients with newly diagnosed, recurrent, and chronic infection caused by P. aeruginosa.
The effect of dual bronchodilatory therapy on the clinical control of chronic obstructive pulmonary disease in real clinical practice
Authors: Trushenko N. V. , Avdeev S. N. , Nuralieva G. S. , Aisanov Z. R. , Suvorova O. A. 
Published: April 2021

Today, achieving clinical control in patients with chronic obstructive pulmonary disease (COPD) remains relevant. Thus, the results of a large multicenter study of clinical efficacy of dual bronchodilatory therapy in real practice conducted in Eastern Europe, including the Russian Federation, are of great interest.Aim. Assessment of changes in the clinical control in patients with COPD receiving treatment with LABA/LAMA combination (tiotropium/olodaterol 5/5 μg via the Respimat® inhaler) in real clinical practice.Methods. The study included patients (n = 1 476) with COPD older than 40 years who were prescribed tiotropium/olodaterol 5/5 μg via the Respimat® inhaler according to the current Russian and foreign clinical guidelines. The observation period was 6 weeks. The clinical control of COPD was assessed by the CCQ questionnaire, the patient’s general condition, the severity of dyspnea according to the mMRC scale, the incidence of using short-acting bronchodilators to relieve symptoms. The criterion for therapeutic success was a 0.4 point decrease in the CCQ score, the minimal clinically important differenceResults. The treatment with tiotropium/olodaterol 5/5 μg was successful, i.e., led to a decrease in the number of CCQ points by more than 0.4 points, in 89.84% of patients (95% CI 88.2 – 91.3 %; p < 0.0001). On average, the overall CCQ score between the first and second visit decreased by 1.31 ± 0.97 points, the severity of symptoms – by 1.39 ± 1.03 points, the functional state – by 1.2 ± 1.1 points, the mental condition – by 1.38 ± 1.31 CCQ points. Achievement of clinical control did not depend on comorbid pathology, disease severity, patient age, and the previous therapy.Conclusion. The results obtained on a wide sample of patients from real practice confirmed the high clinical efficacy of tiotropium/olodaterol 5/5 μg in achieving clinical control of COPD.