bluuebunny/crossref_metadata_2025_split huggingface dataset:
Instagram as a Learning Tool in Neurology: A Prospective Study
Authors: Bakhos Georges T. , Khaled Karine J. Abou 
Published: March 2021

Abstract
Background: Since the beginning of the Covid-19 pandemic, there were remarkable changes in people’s lifestyle with a tendency to spend more time on social media rendering its platforms essential in all fields. This study was designed to look at the potential role of Instagram as a learning tool in neurology among Saint Joseph University (Beirut, Lebanon) medical students.Methods: This prospective study was spread over the period of 3 months, between the 10th of October and the 10th of December 2020. The target population was the medical students at Saint Joseph University (Beirut, Lebanon) in their 3rd to 7th academic year. The purpose was to evaluate the impact of the Instagram page called “La Synapse” on the students’ answers to ten neurology multiple choice questions (MCQs) before and after their exposure to the page’s content. The evaluation was done through a questionnaire conceived on Google Forms that also covered demographical characteristics, social media usage for educational purposes and their feedback post-exposure. In addition, we intended to evaluate the students’ opinion on using social media as a learning tool. The results were analyzed by comparing the pre-exposure and post-exposure data.Results: A total of 180 students were enrolled in the pre-exposure questionnaire (40% of the entire population) and 107 (59.44%) out of the initial group participated in the post-exposure questionnaire. Most students (81%) already used social media for educational purposes with YouTube being the most popular (51%). After exposure, 95% said to have profited from the experience but the junior students benefited more than the seniors. “Mnemonics” were the most practical learning strategy (44%) according to the participants. Regarding the MCQs, an improvement was found in seven out of the ten questions, with three having a statistically significant upswing (p < 0,05).Conclusions: The Instagram page “La Synapse” was an efficient tool for transmitting neurological information to medical students. These results should encourage the development of future prospective studies to better explore the role of social media in medical education.
Evaluation of the Clinical Profile and Malignancies in Children With Neurofibromatosis Type 1
Authors: Şahin Nihal , Demirsoy Ugur , Corapcioglu Funda 
Published: March 2021

Abstract
Purpose: Neurofibromatosis type 1 (NF 1) is a significant disease as it is one of the most common autosomal dominant disorders in childhood. Several systems are affected due to significant progression. This study aimed to analyze the clinical findings in children with NF 1 and investigate the characteristics of those with malignancy. Methods: Medical records of 55 children with NF 1 that were followed up for ten years (2004-2015) in our center were analyzed. We assessed clinical and demographical characteristics of patients, presence NF 1 diagnostic criteria, NF 1 related complications, and malignancies. The patients without malignancy are classified in group 1 while patients with malignancy are in group 2. Results: The mean age was 7.68 ± 4.65 years. Female gender was dominant in both groups. Café au lait spots were present in all patients. Axillary-inguinal freckling was observed in 76.4% of patients, followed by neurofibromas in 30.9%, Lisch nodules in 29.1%, bone dysplasia in 14.5%, optic gliomas (OG) in 23.6%, and a history of first degree relative with NF 1 in 63.6%. Central nervous system (CNS) tumors were present in 40%. Tumors beyond CNS were acute myeloid leukemia and schwannoma. None of the diagnostic criteria was a risk factor for malignancy. Having >3 criteria was the risk factor for malignancy in NF-1 (OR:5.891, CI 95%: 1.676-20.705, p=0.006).Conclusions: The major problem is malignancies in NF -1 patients. There are no clearly defined risk factors predicting malignancies in NF-1 at present. However, we found the risk of malignancy higher in patients with more diagnostic criteria.
Spatial neighborhood intensity constraint (SNIC) clustering framework for tumor region in breast histopathology images
Authors: Tan Xiao Jian , Mustafa Nazahah , Mashor ‪Mohd Yusoff , Rahman Khairul Shakir Ab 
Published: March 2021

Abstract
Precise segmentation of tumor regions plays prominent role in the grading of breast carcinoma using the Nottingham Histological Grading (NHG) system. A robust segmentation framework is expected to produce cost-effective, repeatable, and reproducible quantitative outputs. In this study, a spatial neighborhood intensity constraint (SNIC) clustering framework for tumor region in breast histopathology images is presented. The proposed framework consists of five main stages: (1) color normalization, (2) segmentation and removal of nucleus cells, (3) SNIC, (4) FCM with knowledge-based initial centroids selection, and (5) post-processing. The novelty of the proposed framework lies within its simple but powerful in clustering tumor regions precisely in a heterogenous environment. The SNIC is implemented to remove and replace the intensity of the nucleus cells based on the spatial constraints. Also, a knowledge-based initial centroids selection method is implemented to ease the FCM clustering algorithm. Both of these methods are posited to facilitate the clustering stage producing complementary results. To validate the hypothesis, careful justifications are performed to evaluate the role of SNIC and knowledge-based initial centroids selection. These methods are found plausible by achieving positive results in \(Acc\), \(F1\), \(AOM\), and \(CEI\) of 91.2%, 92.1%, 85.7%, and 90.1%, respectively. To further demonstrate the applicability of the proposed framework, four recent works are included for benchmarking purposes. The proposed framework found outperformed these methods with the lowest percentages in over-segmentation and under-segmentation: 8.7% and 6.6%, respectively.
Safety and Humoral Responses to SARS-CoV-2 mRNA Vaccination of Previously Infected and Naive Populations
Authors: Efrati Shai , Catalogna Merav , Hamed Ramzia Abu , Hadanny Amir , Bar-Chaim Adina , Benveniste-Levkovitz Patricia , Levtzion-korach Osnat 
Published: March 2021

Abstract
Since COVID-19 risk of reinfection is of great concern, the safety and efficacy of the mRNA-based vaccines in previously infected populations should be assessed. We studied 78 individuals previously infected with SARS-CoV-19, who received a single dose of BNT162b2 mRNA COVID-19 vaccine, and 1:2 ratio matched infection-naïve cohort who received two injections. The evaluation procedure included symptom monitoring, and serological tests. Among the post-infected population, the median IgG-S response after the first vaccine dose was 2260 AU/ml, compared to 238 AU/ml after the second vaccine injection in the infection naive group. A strong correlation was demonstrated between IgG-S level before vaccination, and the corresponding responses after a single vaccine dose (r = 0.8, p < 0.001) in the post infected population. Short-term severe symptoms that required medical attention were found in 6.8% among the post-infected individuals, while none were found in the infection naïve population. Our data suggest that a single vaccine dose is sufficient to induce an intense immune response in post-infected population regardless of seropositivity. Although some short-term safety issues were observed compared to the infection naïve population, a single dose regimen can be considered safe in post-infected populations.
First Record of Lobothorax Typus from Odisha Coast, India, with Molecular Characterisation and Observation of its Biphasic Moulting
Authors: Seth Jaya Kishor , Mohanty Swarup Ranjan , Behera Amit Kumar , Murmu Laxman Kumar , Mohapatra Anil 
Published: March 2021

Abstract
Two distinct morphologies of Cymothoidae isopod, Lobothorax typus were collected from the marine water of Bay of Bengal, Goapalpur-on-Sea as the first record of this parasite from coastal water of Odisha, India. All specimens were found attached to the buccal region of different individuals of the same host fish Trichiurus lepturus. With the aid of COI gene sequencing and morphological analysis, the individuals were found to be conspecific. The most prominent variation among the two morphologies includes the size of 5th pereonite and pleon length to total body length ratio. These variations are as a result of the biphasic moulting process. Maximum Likelihood (ML) tree analysis based on COI gene sequences concluded the monophyletic taxonomy of different buccal attaching genera under the family Cymothoidae which is in congruence with their morphological divergence.
Influences of silicon carbide nanowires addition on IMC growth behavior of pure Sn solder during solid-liquid diffusion
Authors: Li Mulan , Zhang Liang , Nan Jiang , Zhong Sujuan , Zhang Lei 
Published: March 2021

Abstract
In this paper, various mass fraction (0, 0.2, 0.4, 0.6, 0.8, 1.0 wt%) of silicon carbide nanowires (SiC) were incorporated into pure Sn solder to enhance the performances of Sn solder joint. The wetting behavior, shear strength and intermetallic compound (IMC) growth mechanism of Sn-xSiC/Cu solder during solid-liquid diffusion at 250°C was investigated systematically. The experiment results demonstrated that the wettability of Sn-xSiC/Cu solder had a significant improvement when the addition of SiC was up to 0.6 wt%, and excessive additives would degrade the wettability of the composite solder. The formation of the Cu6Sn5 IMC layer was observed at the Sn-xSiC solder/Cu interface. Meanwhile, SiC as an additive was conducive to restraining the growth of interfacial IMC during soldering process and the IMC thickness overtly fell down after doping 0.8 wt% SiC into Sn solder. Moreover, SiC addition would contribute to enhancing the mechanical performance of Sn solder joint. The fracture mechanism of solder joint changed from a mix of brittle and ductile fracture to a characteristic of typical ductile fracture.
SWE and SMI Ultrasound Techniques for Monitoring Needling Treatment of Ankylosing Spondylitis: Study Protocol for a Single-blinded Randomized Controlled Trial
Authors: Wang Mengyu , Fu Wen , Meng Lingcui , Liu Jiajia , Wu Lihua , Peng Yingjun , Li Ziping 
Published: March 2021

Abstract
Background: Ankylosing spondylitis (AS) is a high-incidence disease in young men that interferes with patients’ physical and mental wellbeing and overall quality of life (QoL) (7). It is often accompanied by arthralgia, stiffness and limited lumbar flexibility. Acupuncture is safe and effective for reducing the symptoms of AS, but the underlying mechanisms by which it does so are not fully understood. Therefore, to objectively assess acupuncture efficacy, which is critical for patients making informed decisions about appropriate treatments, we will use shear-wave elastography (SWE) and superb microvascular imaging (SMI) ultrasound techniques to evaluate elasticity of lumbar paraspinal muscles and blood flow to the sacroiliac joint (SIJ) in AS.Methods: We will recruit a total of 70 participants diagnosed with AS and 30 healthy subjects. Participants will be randomly allocated 1:1 to either an acupuncture group or a sham control acupuncture group. Primary-outcome measures will be musculoskeletal ultrasound and the Bath Ankylosing Spondylitis Metrology Index (BASMI). Secondary-outcome measures will be the Ankylosing Spondylitis Quality of Life Scale (ASQoL), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Function Index (BASFI), Fatigue Scale-14 (FS-14), Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS). We will monitor the effect of acupuncture or sham acupuncture on blood flow and SIJ inflammation using SMI, lumbar-muscle stiffness using SWE and the lumbar paraspinal-muscle cross-sectional area (CSA) using two-dimensional (2D) grayscale imaging. QoL, physical function and fatigue will be assessed using an evaluation scale or questionnaire developed for this study, with outcomes measured by the ASQoL, BASMI, BASDAI, BASFI and FS-14. Mental state will be evaluated using the SAS and SDS. Healthy subjects will not receive acupuncture but undergo only musculoskeletal ultrasound at baseline. Acupuncture and sham control acupuncture interventions will be conducted for 30 min, 2–3 times/week for 12 weeks. Musculoskeletal ultrasound will be conducted at baseline and post-intervention, while other outcomes will be measured at baseline, 6 weeks and post-intervention. The statistician, outcome assessor and participants will be blinded to treatment allocation.Discussion: The results of this single-blinded, randomized trial with sham controls could help demonstrate the efficacy of acupuncture and clarify whether musculoskeletal ultrasound could be used to evaluate AS.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000031476. Registered April 3, 2020. http://www.chictr.org.cn/index.aspx.
Twist engineering of the two-dimensional magnetism in double bilayer chromium triiodide homostructures
Authors: Xie Hongchao , Luo Xiangpeng , Ye Gaihua , Ye Zhipeng , Ge Haiwen , Sung Suk Hyun , Rennich Emily , Yan Shaohua , Fu Yang , Tian Shang-Jie , Lei Hechang , Hovden Robert , Sun Kai , He Rui , Zhao Liuyan 
Published: March 2021

Abstract
Twist engineering, or the alignment of two-dimensional (2D) crystalline layers with desired orientations, has led to tremendous success in modulating the charge degree of freedom in hetero- and homo-structures, in particular, in achieving novel correlated and topological electronic phases in moiré electronic crystals. However, although pioneering theoretical efforts have predicted nontrivial magnetism and magnons out of twisting 2D magnets, experimental realization of twist engineering spin degree of freedom remains elusive. Here, we leverage the archetypal 2D Ising magnet chromium triiodide (CrI3) to fabricate twisted double bilayer homostructures with tunable twist angles and demonstrate the successful twist engineering of 2D magnetism in them. Using linear and circular polarization-resolved Raman spectroscopy, we identify magneto-Raman signatures of a new magnetic ground state that is sharply distinct from those in natural bilayer (2L) and four-layer (4L) CrI3. With careful magnetic field and twist angle dependence, we reveal that, for a very small twist angle (~ 0.5 degree), this emergent magnetism can be well-approximated by a weighted linear superposition of those of 2L and 4L CI3 whereas, for a relatively large twist angle (~ 5 degree), it mostly resembles that of isolated 2L CrI3. Remarkably, at an intermediate twist angle (~ 1.1 degree), its magnetism cannot be simply inferred from the 2L and 4L cases, because it lacks sharp spin-flip transitions that are present in 2L and 4L CrI3 and features a dramatic Raman circular dichroism that is absent in natural 2L and 4L ones. Our results demonstrate the possibility of designing and controlling the spin degree of freedom in 2D magnets using twist engineering.
Employing Multiple Synchronous Outcome Samples Per Subject to Improve Study Efficiency.
Authors: A'Hern Roger 
Published: March 2021

Abstract
Background: Accuracy can be improved by taking multiple synchronous samples from each subject in a study to estimate the endpoint of interest if sample values are not highly correlated. If feasible, it is useful to assess the value of this cluster approach when planning studies. Multiple assessments may be the only method to increase power to an acceptable level if the number of subjects is limited.Methods: The main aim is to estimate the difference in outcome between groups of subjects by taking one or more synchronous primary outcome samples or measurements. A summary statistic from multiple samples per subject will typically have a lower sampling error. The number of subjects can be balanced against the number of synchronous samples to minimize the sampling error, subject to design constraints. This approach can include estimating the optimum number of samples given the cost per subject and the cost per sample.Results: The accuracy improvement achieved by taking multiple samples depends on the intra-class correlation (ICC). The lower the ICC, the greater the benefit that can accrue. If the ICC is high, then a second sample will provide little additional information about the subject's true value. If the ICC is very low, adding a sample can be equivalent to adding an extra subject. Benefits of multiple samples include the ability to reduce the number of subjects in a study and increase both the power and the available alpha. If, for example, the ICC is 35%, adding a second measurement can be equivalent to adding 48% more subjects to a single measurement study.Conclusion: A study's design can sometimes be improved by taking multiple synchronous samples. It is useful to evaluate this strategy as an extension of a single sample design. An Excel workbook is provided to allow researchers to explore the most appropriate number of samples to take in a given setting.
Accuracy of CT for Measuring Femoral Neck Anteversion in Children With Developmental Dislocation of the Hip Verified Using 3D Printing Technology
Authors: Cai Zhencun , Piao Chengzhe , Zhang Tianyu , Li Lianyong , Xiang Liangbi 
Published: March 2021

Abstract
Background: Accurate femoral neck anteversion angle (FNA) measurement is of great significance in the diagnosis and treatment of developmental dysplasia of the hip (DDH) in children. The FNA measurement still remains a controversy. We aimed to verify the accuracy of our CT method by 3D printing technology , and to evaluate its clinical value. Methods: Sixty-eight children with unilateral DDH were enrolled, and their FNA was measured using 2D-CT and 3D-CT, respectively, by three observers. This procedure was repeated 3 months later. The above measurement outcomes were then compared with the results in the 3D-printed femur (3D-PF) model. The FNA in the 3D-PF model was measured by three observers collectively through electronic angle instrument. Results: The primary measurement of FNA at the affected hips by 2D-CT was 44.0±6.1, 49.5±8.9 and 52.8±7.9 degrees, respectively. On the 3D-CT, it was 47.6±5.4, 49.3±6.8 and 48.6±6.2 degrees. Three months later, the FNA on 2D-CT was 49.3±10.5, 42.8±7.4 and 45.1±9.3 degrees, and it was 48.0±6.5, 48.9±7.2 and 49.0±5.7 degrees on 3D-CT, respectively. The FNA in the 3D-PF model at the affected and unaffected hips was 48.5±6.6 and 36.9±13.1 degrees. There were significant differences between 2D-CT and 3D-PF measurements, but no significant difference was found between 3D-CT and 3D-PF measurements. The results by 2D-CT showed significant differences among groups and between the groups. However, the results by 3D-CT had no significant differences among groups or between the groups. Conclusion: The results of our study showed that 3D-CT is a more precise, and reproducible method for FNA measurement in DDH. The FNA at the affected hips is 11.6 degree larger than the unaffected in DDH children aged 3-8 years.
Better not to quarrel after a sleepless night: preliminary evidence of the negative impact of sleep deprivation on interpersonal conflict
Authors: Curotto Patricia Cernadas , Sterpenich Virginie , Sander David , Favez Nicolas , Rimmele Ulrike , Klimecki Olga 
Published: March 2021

Abstract
Although poor sleep has been found to correlate with deteriorations in romantic relationships, its causal impact on interpersonal conflict has not previously been studied. Therefore, 30 couples were randomly assigned to either a single night of total sleep deprivation or a night of normal sleep to test the effects of sleep deprivation on couples’ conflict. After the experimental night, all participants discussed a topic of recurrent conflict for 15 minutes. We collected pre- and post-conflict measures of cortisol, self-reports of feelings and satisfaction with the conflictual discussion. Multilevel analyses revealed higher cortisol levels during conflict and less positive affect prior to and after the conflict for sleep-deprived couples compared to couples in the control condition. Additionally, higher cortisol levels during the conflict predicted lower satisfaction about the content of the conflict among sleep-deprived couples. These findings provide initial evidence for a causal negative impact of sleep deprivation on couples’ conflicts.
Processing methodology of global anthropogenic for air quality modeling
Authors: Pino-Cortés Ernesto 
Published: March 2021

Abstract
The Global Emissions Initiative (GEIA) storages and offers global datasets of emission inventories developed in the last 30 years. One of the most recently updated global datasets covering anthropogenic source emissions is the Copernicus Atmosphere Monitoring Service (CAMS). This study applied the NetCDF Command Operator (NCO) software to preprocess the anthropogenic sources included in the CAMS datasets and converted those files as an input in the Sparse Matrix Operator Kerner Emissions (SMOKE) model for future air quality modeling. As a result, six steps were applied to obtain the required file format. The case of the Central coast in Chile was analyzed to compare the global database and the official reports for the on-road transport sector. As a result, some differences were shown in the most populated locations of the domain of analysis. The rest of the zones registered similar values. The methodology exposed in this report could be applied in any other region of the planet for air quality modeling studies. The development of global datasets like CAMS is useful for hemispheric analysis and it could bring an estimation on the mesoscale scale. It represents an opportunity for those locations without official reports of non-updated data.
Design and Psychometric Evaluation of the Fathers' Fear of Childbirth Scale: An Explanatory Sequential Mixed Method Study
Authors: Ghaffari Seyedeh Fatemeh , Shahhosseini Zohreh , Nia Hamid Sharif , Elyasi Forouzan , Mohammadpoorsaravimozafar Zohre 
Published: March 2021

Abstract
Background: Fear of childbirth was reported in 13% of fathers that may have consequences for the health of fathers and their families. Given the lack of a valid and reliable questionnaire for measure fathers' fear of childbirth, this study was designed with the aim of design and develop Fathers' Fear of Childbirth Scale and evaluate its psychometric properties.Methods: This methodological study with explanatory sequential mixed method approach was conducted in two phases. In the qualitative phase (or item generation), semi-structured interviews were conducted with twenty fathers, and a literature review was done to generate Fathers' Fear of Childbirth Scale items pool. In the quantitative phase (or psychometric evaluation), face, content, construct as well as reliability of the Fathers' Fear of Childbirth Scale were evaluated. For construct validity, exploratory and confirmatory factor analyses were performed with assistance of 433 expectant fathers. Reliability was also evaluated through internal consistency and composite reliability.Results: The primary Fathers' Fear of Childbirth Scale contained 32 items which reduced to 17 items after face and content validity. Exploratory factor analysis extracted two factors: Fear of childbirth process (12 items), fear of (five items). These factors explained %50.82 of total variance. Goodness of fit indices within a confirmatory factor analysis was acceptable. Internal consistency and composite reliability indices of all factors were greater than 0.70.Conclusion: The Fathers' Fear of Childbirth Scale has a suitable validity and reliability instrument for assessing fear of childbirth in fathers.