bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Mechanical Anal Dilatation: A Simple Trick to Minimize Postoperative Pain and Stenosis Following Hemorrhoidectomy With Radiofrequency
Authors: Eberspacher Chiara , Mascagni Pietro , Zeri Kenneth Paul , Fralleone Lisa , Naldini Gabriele , Mascagni Domenico 
Published: September 2021

Aim: Hemorrhoidectomy is still the most effective surgical treatment for hemorrhoidal disease, but it is, however, associated with complications such as pain and stenosis. We proposed to break the “vicious circle” of “pain–sphincteric spasm–stenosis–pain” with the postoperative use of self-mechanical anal dilation.Methods: We retrospectively analyzed patients with hemorrhoidal disease presenting with a minimum of piles of three quadrants, treated with radiofrequency hemorrhoidectomy between January 2018 and December 2019. All the patients that at 3 weeks presented sphincteric spasms with painful defecation, were considered. Thirty-nine patients performed the cycle of self-mechanical anal dilation (Group A). This group was 1:1 matched with homogeneous patients from our historical cohort of patients (Group B). The primary endpoint was the pain evaluation, secondary endpoints: WCS, overall satisfaction of the patient, anal sphincter spasm, scarring, and the incidence of postoperative stenosis.Results: In Group A mean VAS was 3.25 after 14 days of application and 1.15 at the end of the application. In Group B mean VAS was persistently higher, with a mean VAS of 5 (p = 0.000002) and 3.38 (p = 0.0000000000009). In Group A we observed an improvement of symptoms at the end, with a good overall satisfaction (Group A 7.4 vs. Group B 5.9; p = 0.0000007) and a better mean WCS (Group A WCS 2.8 vs. Group B WCS 4.18; p = 0.0001). Stenosis was observed in 3/39 patients of Group B (7.7%).Conclusions: Self-mechanical anal dilation improves the pain in the late postoperative course, minimizing the risk of anal stenosis.
RETRACTED: Open Resection Compared to Mini-Invasive in Colorectal Cancer and Liver Metastases: A Meta-Analysis
Authors: Gong Jie , Gao Fengwei , Xie Qingyun , Zhao Xin , Lei Zehua 
Published: September 2021

Background: We performed a meta-analysis to evaluate the outcomes of minimally invasive surgery and open surgery in the simultaneous resection of colorectal cancer and synchronous colorectal liver metastases.Methods: A systematic literature search up to April 2021 was done and 13 studies included 1,181 subjects with colorectal cancer and synchronous colorectal liver metastases at the start of the study; 425 of them were using minimally invasive surgery and 756 were open surgery. They were reporting relationships between the outcomes of minimally invasive surgery and open surgery in the simultaneous resection of colorectal cancer and synchronous colorectal liver metastases. We calculated the odds ratio (OR) or the mean difference (MD) with 95% CIs to assess the outcomes of minimally invasive surgery and open surgery in the simultaneous resection of colorectal cancer and synchronous colorectal liver metastases using the dichotomous or continuous method with a random or fixed-effect model.Results: Minimally invasive surgery in subjects with colorectal cancer and synchronous colorectal liver metastases was significantly related to longer operation time (MD, 35.61; 95% CI, 7.36–63.87, p = 0.01), less blood loss (MD, −151.62; 95% CI, −228.84 to −74.40, p &lt; 0.001), less blood transfusion needs (OR, 0.61; 95% CI, 0.42–0.89, p = 0.01), shorter length of hospital stay (MD, −3.26; 95% CI, −3.67 to −2.86, p &lt; 0.001), lower overall complications (OR, 0.59; 95% CI, 0.45–0.79, p &lt; 0.001), higher overall survival (OR, 1.66; 95% CI, 1.21–2.29, p = 0.002), and higher disease-free survival (OR, 1.49; 95% CI, 1.13–1.97, p = 0.005) compared to open surgery.Conclusions: Minimally invasive surgery in subjects with colorectal cancer and synchronous colorectal liver metastases may have less blood loss, less blood transfusion needs, shorter length of hospital stay, lower overall complications, higher overall survival, and higher disease-free survival with longer operation time compared with the open surgery. Furthers studies are required to validate these findings.
ONLINE LEARNING IN THE POST-COVID EDUCATIONAL SPACE OF PEDAGOGICAL HIGHER EDUCATION
Authors: Rastrygina A. , Koloskova Z. 
Published: September 2021

The article highlights the issues related to the need of introducing online education as an innovative form of learning in the post-COVID educational space of pedagogical educational establishments, mastering which becomes the basis for the development of specific elements of digital competence of future specialists.
It was stated that in finding ways to solve problems in the system of pedagogical higher education caused by the COVID-19 pandemic and its probable continuation over a long period, scientists stressed the need to respond immediately to new circumstances and introduce distance learning using various web servers, platforms and resources, and social networks.
Given the analysis of scientific sources and the results of expert verification of the feasibility of using digital assistive devices during the transition to distance learning related to quarantine measures, it is confirmed that most scientists from the world-leading universities have confirmed the effectiveness of combining common forms of offline learning with distance learning on the online platform and supported the introduction of blended learning in the post-COVID educational space of higher education institutions.
The use of online learning in the post-COVID educational space of pedagogical institutions of higher education, regardless of the format of its receiving (online or offline), is standardized at the national level and confirmed in the documents of the State Education Quality Service of Ukraine.
The content and forms of the distantly conducted classes are presented in the example of art subjects. Not only does it cause the change of teaching technologies in the art educational space of higher education institutions, but it also becomes an essential factor in improving the professional culture of a modern music teacher.
Sinusitis de origen odontogénico.
Authors: Arias Amador Kimberly , Rojas Díaz Sofía , Saenz Ramirez Viviana 
Published: September 2021

La pansinusitis se define como la inflamación de todos los senos paranasales, de uno o los dos lados de la nariz, a consecuencia de la invasión por bacterias, virus u hongos, el cual puede ser causada por la evolución de una lesión en el diente con formación de pus periapical que avanza en el interior de la cavidad sinusal. (1)
La evaluación temprana de los pacientes que manifiesten invasiones dentales es esencial con el fin de evitar las complicaciones clínicas que puedan detonar en la penetración de dicha cavidad. Del mismo modo se debe estar atento a realizar un diagnóstico temprano y la respectiva cobertura antibiótica en conjunto con las pruebas de sensibilidad antibiótica en pacientes con empeoramiento del cuadro clínico de origen odontogénico.
TELECOMMUNICATION NETWORKS AS A BASE FOR BRIDGING THE DIGITAL DIVIDE BETWEEN RUSSIAN FEDERATION REGIONS
Authors: ЧИСТОВА Н.А. , БОРОДИН А.С. , КУЧЕРЯВЫЙ А.Е. 
Published: September 2021

Статья посвящена анализу возможностей сетей связи для сокращения цифрового разрыва между регионами Российской Федерации. Основным результатом статьи является установление взаимосвязи валового регионального продукта и доли занятых в сфере информатизации и связи в общем числе занятых во всех отраслях. Результаты статьи могут быть использованы заинтересованными министерствами и ведомствами при реализации программы цифровой экономики, научными и проектными организациями при планировании и проектировании сетей связи, а также университетами в учебном процессе.
The article is devoted to the analysis of the capabilities of telecommunication networks with ultralow latency to reduce the digital divide between the regions of the Russian Federation. The main result of the article is to establish the relationship between the gross regional product and the share of people employed in the field of informatization and communications in the total number of people employed in all industries. The results of the article can be used by interested ministries and departments in the implementation of the digital economy program, scientific and design organizations in the planning and design of communication networks, as well as by universities in the educational process.
Krom (III) Klorür Tuzuna Maruz Kalan Saccharomyces cerevisiae’nın Stres Yanıtı
Authors: ÇÖTELİ Ebru , KARATAŞ Fikret , GÜR Seher 
Published: September 2021

Bu çalışmada, iki farklı dozda (10 ve 40 µg/mL) krom III klorür (CrCl3.6H2O) tuzuna maruz kalan maya (Saccharomyces cerevisiae)’ların ortamına 10, 15 ve 20 µg/mL C vitamini katıldı. Daha sonra mayaların 12, 24 ve 36. saat sonra canlılık oranları belirlendi. Bu mayaların A, E, C vitaminleri, glutatyon (GSH ve GSSG) ve malondialdehit (MDA) miktarları HPLC ile tayin edildi.
Artan krom dozu ve süreye bağlı olarak canlılık oranlarında, GSH, A, E ve C vitamini miktarlarında azalma, GSSG ve MDA miktarlarında ise artmaların olduğu belirlendi. Ayrıca artan C vitamini dozuna bağlı olarak canlılık oranları, GSH, A, E ve C vitamini miktarlarında artma, GSSG ve MDA miktarlarında azalmaların olduğu gözlendi. Artan krom dozuyla mayalarda metabolik strese bağlı olarak serbest radikal oluşumunda artış olduğu, bunun indirekt göstergesi olan MDA miktarında artışlar ve GSH/GSSG oranında ise azalmalar olduğu belirlendi.
Tüm bu bulgulardan kromun; serbest radikal oluşumunu artırdığı ve ortama ilave edilen C vitamininin antioksidan özelliğinden dolayı, serbest radikal oluşumunu azalttığı gözlenmiştir.
La libertad conquistada: Consideraciones sobre manumisión, gratitud y coerción en Charcas colonial (siglos XVI-XVIII)
Authors: Revilla Orías Paola A. 
Published: September 2021

El texto se adentra en las formas de manumisión de esclavos que residieron en la ciudad de La Plata, Charcas colonial. Propone su análisis como procesos complejos, develando mecanismos coercitivos desplegados por los amos para perpetuar el control sobre los esclavizados, así como la hábil acción de estos en su lucha por la consecución de la libertad legal. Estudia los efectos de la violencia de la palabra no cumplida, no escrita y no respetada, que arriesgó con sumergir a los coartados, libertos, manumisos en un limbo de servidumbre no-libre por tiempo indefinido. Así también, de la gratitud como valor social de corte paternalista que legitimó relaciones asimétricas de dependencia y pudo condicionar a las personas a vivir en servidumbre.
Reseñas bibliográficas
Authors: Delgado Emilia Sol , Abreu Colombri José Antonio , Calzini Gianfranco , Varas Adela Alejandra 
Published: September 2021

Vázquez, C. (2020). Campesinos de pie. La formación del movimiento campesino en Formosa. Universidad Nacional de General Sarmiento- Universidad Nacional de La Plata - Universidad Nacional de Misiones: Los Polvorines. La Plata: Posadas, 211 páginas.

Ríos, J. (2019). Un franquismo con franquistas. Sevilla: Editorial Renacimientos, 396 páginas.

De Cristóforis, N. (Dir.) (2020). Los españoles en Buenos Aires. Activismo político e inserción sociocultural (1870-1960). Teseo: Buenos Aires, 340 páginas.

Moreno Fabaro, C.; Ferrari, A.; Mercado, R.; Vera, C. y Coria Blarasin, L. (2019). Prácticas de fe. San Juan, siglos XIX y XX. UNSJ: San Juan, 167 páginas
El Frente de Liberación Nacional y Social: en busca de una definición. El PCA durante la posdictadura
Authors: Casola Natalia 
Published: September 2021

El presente artículo analiza la política del Partido Comunista Argentino (PCA) durante los años 1980, es decir, en el contexto de la posdictadura y de la expectativa social generada por la recuperación de la democracia. En este trabajo se sostiene que el devenir del PCA debe leerse a la luz de una triple transición: la llamada “transición democrática” en el país, la del mundo socialista en su etapa de crisis final, y la propia, signada por una irrefrenable necesidad de cambio interno que tuvo como punto central el XVI Congreso de 1986. Toda la política partidaria desarrollada con posterioridad remonta su legitimidad a las Tesis aprobadas ese año, consideradas de un modo casi refundacional.
A grandes rasgos, el trabajo propone un análisis de la evolución de la línea partidaria, sintetizada en la estrategia de Frente de Liberación Nacional y Social (FLNS). Se trataba de una vieja consigna resignificada en el nuevo contexto. La hipótesis central de este artículo es que la línea del partido entre 1983 y 1990 fue dinámica y se caracterizó por una progresiva e ininterrumpida radicalización no exenta de indefiniciones que fueron el puntapié para las sucesivas crisis. No obstante, sistematizar los cambios en la línea, contribuirá a comprender mejor cuáles eran los debates y argumentos detrás de las rupturas.
The Clinical Utility of Kinetic Glomerular Filtration Rate in the Assessment of Renal Function and Prediction of Outcomes Among Critically Ill Patients With Acute Kidney Injury: A Single-Center Retrospective Cohort Study
Authors: Atanacio Shari Ann , Uy Maria Rachel 
Published: September 2021

Objective: To determine the discriminatory ability of kinetic glomerular filtration rate (kGFR) to detect acute kidney injury (AKI) when compared with established GFR equations and criteria and relating it to mortality, renal replacement therapy initiation and renal recovery. Methods: This was a retrospective analysis using data from chart review of 109 intensive care unit (ICU) patients at the University of Santo Tomas Hospital (USTH). The renal function estimates using Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi), modification of diet in renal disease (MDRD), Kidney Disease Improving Global Outcomes Acute Kidney Injury (KDIGO AKI), as well as kinetic GFR equations were compared and correlated with renal and cardiovascular outcomes. Results: The renal function assessed by kGFR, CKD-Epi, MDRD and KDIGO staging based on serum creatinine (SCr) showed no significant association with mortality outcomes. However, AKI diagnosed based on urine output (UO), and combined SCr and urine output (KDIGO) showed association with all-cause mortality. The UO detected severe stages of AKI while SCr (based on KDIGO) better identified the earlier stages of AKI. The criteria for KDIGO AKI when combined also shows mortality prediction since it joins together the effects of SCr and UO. There was a remarkable 3.5 times increase in hemodialysis initiation (p=0.0001) and 12.89 times increase in peritoneal dialysis initiation (p=0.01) for every stage increase in the KDIGO classification. kGFR, CKD-Epi and MDRD have 5%, 6%, and 6% decrease, respectively in the odds of initiating hemodialysis. There was however, no association for peritoneal dialysis. Conclusion: kGFR was the least able in detecting AKI and KDIGO AKI criteria remains to be the standard in identifying AKI in the critical care setting. Increase in SCr was a sensitive tool in diagnosing AKI due to its ability to detect AKI based on a small increase in SCr regardless of the baseline renal function. Decreasing UO, however, is the prognosticating variable in KDIGO AKI criteria, in that it portends higher probability of initiation of renal replacement therapy (RRT) and ultimately higher mortality when present.
Chemotherapy-Induced Leukoencephalopathy: A Case Series
Authors: Nuqui Paula Bianca E , Hernandez Flerida G 
Published: September 2021

Rationale: Leukoencephalopathy, a complication associated with chemotherapy has been reported after giving high doses of methotrexate and cytarabine with no specific risk factors to date. Objectives: To review the prevalence of chemotherapy-induced leukoencephalopathy in children with acute lymphoblastic leukemia (ALL). To present the clinical course, pathogenesis and neuro-imaging findings of chemotherapy-induced leukoencephalopathy in children with ALL. Case: We reported three cases of adolescent ALL precursor B-cell patients who received high doses of methotrexate and presented with neurologic and MRI findings consistent with leukoencephalopathy. Our patients were only placed on supportive measures with adequate hydration, without providing any special intervention. Yet, all of them had complete neurological recovery. Discussion and Summary: Methotrexate is a cell cycle-specific agent that inhibits the enzyme dihydrofolate reductase, preventing the conversion of folic acid to tetrahydrofolic acid and inhibiting cell replication. It is one of the most commonly implicated drug causing leukoencephalopathy.[3] On MRI T2-weighted images, all of them had hyperintensities on the posterior frontal/parietal corona radiata and centrum semiovale consistent with leukoencephalopathy. Complete recovery happened spontaneously in all of the cases. There is no standard treatment for acute and subacute toxicities from methotrexate. Keywords: Leukoencephalopathy, Chemotherapeutic drugs, Neurotoxicity, Case series
PENGARUH HARGA DAN KUALITAS PELAYANAN TERHADAP KEPUASAN PELANGGAN JASA TRANSPORTASI ONLINE GRABBIKE
Authors: Boimau Hezron , Bessie Juita L D 
Published: September 2021

This study aims to find out and analyze 1) Perception of customers on the price, quality of service and customer satisfaction of GrabBike online transportation services in Kupang City; 2) impact of Price partially on Customer Satisfaction of GrabBike online transportation service in Kupang City; 3) The partial effect of Service Quality on Customer Satisfaction of GrabBike online transportation services in Kupang City; 4) The effect of Price and Quality of Service simultaneously on the Customer Satisfaction of GrabBike online transportation service customers in Kupang City. The number of samples in this study as many as 100 respondents obtained using accidental sampling techniques. The data was collected using questionnaires, interviews, and literature study. The data analysis techniques used are quantitative descriptive, multiple linear regression analysis and hypothesis testing using SPSS 16 applications. From the results of the analysis showed that: 1) Based on the results of descriptive table analysis respondents gave a very high categorized assessment of the three variables studied; 2) The price partially affects the customer satisfaction of GrabBike Kupang City; 3) the quality of service partially affects the customer satisfaction of GrabBike Kupang City; 4) The price and quality of service simultaneously have a significant impact on the customer satisfaction of GrabBike Kupang City. Based on Adjusted R2 value shows variable contribution of Price and Service Quality to Customer Satisfaction of 57.8%. While 42.2% were influenced by other variables outside the focus of this study.
Keywords: Price, Quality of Service and Customer Satisfaction
PENGARUH KOMPETENSI DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN BAGIAN ZC. ASSEMBLING PT. XYZ
Authors: Ilyas Yasnimar , Amelia Kiki 
Published: September 2021

XYZ is a company that produces apparel accessories that has been established for more than 30 years. However, there is a problem in decreasing of employee performance that can be seen on the attendance data of the employees. So, it is necessary to conduct a research to see what factors cause a decrease in employee performance. The purpose of this research is to see the relationship and influence between Competence and Work Environment on the Employee Performance. The method in this research is multiple linear regression. The results of data analysis in this study show that Competence has a significant influence on Employee Performance. The Work Environment does not have a significant effect on employee performance. Competence and Work Environment simultaneously have a significant effect on Employee Performance. In the determinant coefficient test (R²), the influence of Competence and Work Environment on Employee Performance is quite high as many as 0.555 or 55.5%. This means that Competence and Work Environment have a contribution of 55.5% to explain the Employee Performance, while 44.5% of other variables are not discussed in this study. Based on the regression test, the variable that most affected Employee Performance was the Competency variable (X1) with a value of 0.486 (positive value).
Keywords: Competence, Work Environment, Employee Performance
ANALISIS PERAN DIGITAL CONTENT MARKETING BAGI WIRAUSAHA MILENIAL DI KOTA KUPANG DALAM MASA PANDEMI COVID-19
Authors: Kamuri Klaasvakumok Jehezkielomi 
Published: September 2021

One of the impacts caused by the Covid-19 pandemic is the limited interaction of the community in various activities, including business activities, causing Indonesia to experience a 0.1% decline in economic growth in 2020, and more than 50% of Small and Medium Enterprises have become victims. However, the limited interaction in business activities is not a major problem for the millennial generation. They have sufficient skills and knowledge in utilizing technology to carry out their business activities. The method used today is marketing through digital content which is known as digital content marketing. Many business people have started to switch to modern marketing based on digital technology because it is considered more effective and can be done in various situations and conditions, including during the Covid-19 pandemic. This study aims to examine the role of digital content marketing towards the efforts made by millennial entrepreneurs in Kupang City during the Covid-19 pandemic. The method used in this research is descriptive qualitative in order to obtain data and facts related to the research problem directly. Through the results and discussion, it was concluded that digital content marketing plays an important role in creating cost-effective promotions, increasing sales, communication media and effective and up to date marketing information. Digital content marketing plays a role in building brand awareness and consumer loyalty, being a means of developing creativity and knowledge of business actors in utilizing technology for business, and creating competitive advantages for millennial entrepreneurs in Kupang City.
Keywords: Digital Content Marketing, Entrepreneurship, Millennial Generation
Next generation sequencing HLA-typing of recipients and donors of allogeneic haematopoietic stem cells
Authors: Khamaganova E. G. , Abdrakhimova A. R. , Leonov E. A. , Khizhinskiy S. P. , Gaponova T. V. , Savchenko V. G. 
Published: September 2021

Introduction. The patient survival after allogeneic haematopoietic stem cell transplantation (allo-HSCT) from an unrelated or related haploidentical donor is improved in a donor–recipient match resolution at the level of non-coding region identity of HLA genes. Next-generation sequencing (NGS) allows detection of point substitutions in HLA non-coding regions.Aim — assessment of the NGS-based HLA-typing performance.Materials and methods. An NGS-based HLA-typing of 1,056 DNA samples from allo-HSCT recipients, their related and registry donors was performed with AllTypekit chemistry (OneLambda, USA). A parallel HLA-typing assay of 96 samples by 8 genes (A/B/C/DRB1/DRB3/DRB4/DRB5/DQB1) was accomplished within one working week.Results. HLA class I genes were typed at a 4-field (allelic), and HLA class II genes — 2–4-field (high to allelic) resolution. An allelic-resolution typing of HLA class I genes in a Russian population (657 registry donors) was conducted for the first time. The most frequent HLA alleles have been identified: А*02:01:01:01 in HLA-A (26.9 %), B*07:02:01:01 in HLA-B (12.5 %) and C*07:02:01:03 in HLA-C (12.6 %). The most frequent HLA class II variants were DRB1*07:01:01 (14.1 %), DRB3*02:01:01 (18.0 %), DRB4*01:03:01 (18.9 %), DRB5*01:01:01 (13.5 %), DQB1*03:01P (17.4 %).Conclusion. An NGS-geared HLA-typing has yielded low-ambiguity allelic and high-level resolution results in a parallel sequencing assay with a large number of samples. The method implemented detects genetic polymorphisms also in non-exonic non-coding regions of HLA genes and facilitates typing in candidate HSCT recipients, related and unrelated donors.