bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer
Authors: D’Andrea David , Black Peter C. , Zargar Homayoun , Zargar-Shoshtari Kamran , Soria Francesco , Fairey Adrian S. , Mertens Laura S. , Dinney Colin P. , Mir Maria C. , Krabbe Laura-Maria , Cookson Michael S. , Jacobsen Niels-Erik , Montgomery Jeffrey S. , Vasdev Nikhil , Yu Evan Y. , Xylinas Evanguelos , Campain Nicholas J. , Kassouf Wassim , Dall’Era Marc A. , Seah Jo-An , Ercole Cesar E. , Horenblas Simon , Sridhar Srikala S. , McGrath John S. , Aning Jonathan , Wright Jonathan L. , Thorpe Andrew C. , Morgan Todd M. , Holzbeierlein Jeff M. , Bivalacqua Trinity J. , North Scott , Barocas Daniel A. , Lotan Yair , Grivas Petros , Stephenson Andrew J. , Shah Jay B. , van Rhijn Bas W. , Daneshmand Siamak , Spiess Philippe E. , Shariat Shahrokh F. 
Published: August 2021

Abstract
Purpose
To assess the association of patient age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer (MIBC).

Materials and methods
We analyzed data from 1105 patients with MIBC. Patients age was evaluated as continuous variable and stratified in quartiles. Pathologic objective response (pOR; ypT0-Ta-Tis-T1N0) and pathologic complete response (pCR; ypT0N0), as well survival outcomes were assessed. We used data of 395 patients from The Cancer Genome Atlas (TCGA) to investigate the prevalence of TCGA molecular subtypes and DNA damage repair (DDR) gene alterations according to patient age.

Results
pOR was achieved in 40% of patients. There was no difference in distribution of pOR or pCR between age quartiles. On univariable logistic regression analysis, patient age was not associated with pOR or pCR when evaluated as continuous variables or stratified in quartiles (all p > 0.3). Median follow-up was 18 months (IQR 6–37). On Cox regression and competing risk regression analyses, age was not associated with survival outcomes (all p > 0.05). In the TCGA cohort, patient with age ≤ 60 years has 7% less DDR gene mutations (p = 0.59). We found higher age distribution in patients with luminal (p < 0.001) and luminal infiltrated (p = 0.002) compared to those with luminal papillary subtype.

Conclusions
While younger patients may have less mutational tumor burden, our analysis failed to show an association of age with response to preoperative chemotherapy or survival outcomes. Therefore, the use of preoperative chemotherapy should be considered regardless of patient age.
Cardiorespiratory monitoring of red blood cell transfusions in preterm infants
Authors: Poppe Jarinda A. , van Essen Tanja , van Weteringen Willem , Willemsen Sten P. , Reiss Irwin K. M. , Simons Sinno H. P. , de Jonge Rogier C. J. 
Published: August 2021

AbstractClinical improvement after red blood cell (RBC) transfusions in preterm infants remains debated. This study aims to investigate the effect of RBC transfusion on the occurrence of desaturations and hypoxia, and other cardiorespiratory outcomes in preterm infants. In this longitudinal observational study, prospectively stored cardiorespiratory parameters of preterm infants who received at least one RBC transfusion between July 2016 and June 2017 were retrospectively analyzed. Sixty infants with 112 RBC transfusions, median GA of 26.7 weeks, were included. The number of desaturations and area < 80% SpO2 limit, as a measure of the hypoxic burden, were calculated in 24 h before and after RBC transfusion. A mixed effects model was used to account for repeated measurements. Overall, the mean (SE) number of desaturations per hour decreased from 3.28 (0.55) to 2.25 (0.38; p < 0.001), and area < 80% SpO2 limit decreased from 0.14 (0.04) to 0.08 (0.02) %/s (p = 0.02). These outcomes were stratified for the number of desaturations in 24 h prior to RBC transfusion. The largest effect was observed in the group with the highest mean number of desaturations (≥ 6) prior to RBC transfusion, with a decrease from 7.50 (0.66) to 4.26 (0.38) (p < 0.001) in the number of desaturations and 0.46 (0.13) to 0.20 (0.06) in the area < 80% SpO2. Perfusion index increased significantly after RBC transfusion (p < 0.001). No other significant effects of RBC transfusion on cardiorespiratory data were observed.Conclusions: RBC transfusions in preterm newborns could help decrease the incidence of desaturations and the area < 80% SpO2 as a measure of the hypoxic burden. The higher the number of desaturations prior to the RBC transfusion, the larger the effect observed.

What is Known:•Red blood cell transfusions potentially prevent hypoxia in anemic preterm infants by increasing the circulatory hemoglobin concentration and improving tissue oxygenation.•There is not a predefined hemoglobin concentration cut-off for the occurrence of symptomatic anemia in preterm infants.

What is New:•Oxygen desaturations and hypoxia in anemic preterm infants can be improved by RBC transfusions, especially if more desaturations have occurred before transfusion.•Cardiorespiratory monitor data may help identify infants who will benefit most from red blood cell transfusions.
Crizotinib: aseptic abscesses in multiple organs during treatment of EML4-ALK-positive NSCLC
Authors: Weber Daniel , Decker Miriam , Schuster Michael , Folz Sara , Stürmer Carsten Johannes , Lutz Manfred P. 
Published: August 2021

Abstract
Purpose
We report a novel side effect of Crizotinib, an oral ALK inhibitor used in the treatment of non-small cell lung cancer (NSCLC) with activating rearrangement of EML4-ALK. It expands the known spectrum of complications of Crizotinib.

Methods
Clinical case report.

Results
Multiple aseptic and recurrent abscesses were observed in the liver, thoracic wall as well as in both kidneys in a 75-year-old female patient suffering from NSCLC who had been treated with Crizotinib for almost 2 years. After discontinuation of the treatment the abscesses dissolved spontaneously and did not reoccur.

Conclusion
Aseptic abscesses under treatment with Crizotinib are not restricted to the kidneys as described before, but can also occur in other abdominal organs as the liver and even in the thoracic wall. We postulate that this finding may point to a yet unknown not tissue-dependent mechanism of action.
Metagenomic analysis of nepoviruses: diversity, evolution and identification of a genome region in members of subgroup A that appears to be important for host range
Authors: Hily J. M. , Poulicard N. , Kubina J. , Reynard J. S. , Spilmont A. S. , Fuchs M. , Lemaire O. , Vigne E. 
Published: August 2021

AbstractData mining and metagenomic analysis of 277 open reading frame sequences of bipartite RNA viruses of the genus Nepovirus, family Secoviridae, were performed, documenting how challenging it can be to unequivocally assign a virus to a particular species, especially those in subgroups A and C, based on some of the currently adopted taxonomic demarcation criteria. This work suggests a possible need for their amendment to accommodate pangenome information. In addition, we revealed a host-dependent structure of arabis mosaic virus (ArMV) populations at a cladistic level and confirmed a phylogeographic structure of grapevine fanleaf virus (GFLV) populations. We also identified new putative recombination events in members of subgroups A, B and C. The evolutionary specificity of some capsid regions of ArMV and GFLV that were described previously and biologically validated as determinants of nematode transmission was circumscribed in silico. Furthermore, a C-terminal segment of the RNA-dependent RNA polymerase of members of subgroup A was predicted to be a putative host range determinant based on statistically supported higher π (substitutions per site) values for GFLV and ArMV isolates infecting Vitis spp. compared with non-Vitis-infecting ArMV isolates. This study illustrates how sequence information obtained via high-throughput sequencing can increase our understanding of mechanisms that modulate virus diversity and evolution and create new opportunities for advancing studies on the biology of economically important plant viruses.
Analysis of the nodal beam isolation system based on application of helical spring
Authors: Michalczyk Krzysztof , Sikora Wojciech 
Published: August 2021

AbstractA nodal beam isolation system allows the transmission of vibration from the source to an isolated element to be limited using nodal points on the elastic beam connecting them. These points are selected in such a way that their position during vibration is constant. The application of a helical spring as an elastic beam reduces the dimensions of the system and increases its applications. An effective computational model of the nodal beam isolation system based on a helical spring application as an elastic beam is presented in the paper. The model allows the position of nodal points to be determined for a given excitation frequency. It also allows the influence of system parameters on spring vibration amplitudes and static stiffness of the connection between the source and isolated element to be analysed. The analysis makes it possible to formulate conclusions facilitating the designer to select the proper system parameters for the given operating conditions. The results of numerical and experimental tests exhibit high compliance with the results of the presented model.
A new time-delayed periodic boundary condition for discrete element modelling of railway track under moving wheel loads
Authors: Li Huiqi , McDowell Glenn , de Bono John 
Published: August 2021

Abstract
A new time-delayed periodic boundary condition (PBC) has been proposed for discrete element modelling (DEM) of periodic structures subject to moving loads such as railway track based on a box test which is normally used as an element testing model. The new proposed time-delayed PBC is approached by predicting forces acting on ghost particles with the consideration of different loading phases for adjacent sleepers whereas a normal PBC simply gives the ghost particles the same contact forces as the original particles. By comparing the sleeper in a single sleeper test with a fixed boundary, a normal periodic boundary and the newly proposed time-delayed PBC (TDPBC), the new TDPBC was found to produce the closest settlement to that of the middle sleeper in a three-sleeper test which was assumed to be free of boundary effects. It appears that the new TDPBC can eliminate the boundary effect more effectively than either a fixed boundary or a normal periodic cell.

Graphic abstract
Real-world evaluation of effectiveness, persistence, and usage patterns of monotherapy and combination therapy tofacitinib in treatment of rheumatoid arthritis in Australia
Authors: Bird Paul , Littlejohn Geoffrey , Butcher Belinda , Smith Tegan , O’Sullivan Catherine , Witcombe David , Griffiths Hedley 
Published: August 2021

Abstract
Objective
This study aimed to describe the real-world effectiveness and treatment persistence among patients with rheumatoid arthritis treated with monotherapy and combination therapy tofacitinib and biologic disease-modifying antirheumatic drugs (bDMARDs).

Methods
This was a post hoc analysis of a retrospective, non-interventional study that extracted data for patients treated with tofacitinib or bDMARDs from the Australian OPAL dataset between March 2015 and September 2018. Monotherapy tofacitinib and bDMARDs and combination therapy tofactinib and bDMARDs were propensity score matched and treatment effectiveness and persistence of the groups were evaluated.

Results
In the bDMARD and tofacitinib monotherapy and combination therapy matched populations there were 1300 bDMARD initiators (n = 564 monotherapy) and 650 tofacitinib initiators (n = 282 monotherapy). In the bDMARD and tofacitinib monotherapy matched groups, 62.9% and 66.7% were in DAS-28 CRP disease remission after 18 months of treatment, respectively. In the combination therapy bDMARD and tofacitinib groups, 50% and 58.9% were in DAS-28 CRP disease remission after 18 months, respectively. The median treatment persistence was similar between the monotherapy bDMARD and tofacitinib treatment groups (36.7 months (95% CI 27.4 to “not reached’) and 34.2 months (95%CI 30.3 to “not reached”) respectively) as well as the combination therapy bDMARD and tofacitinib groups (32.2 months (95% CI 25.7 to 34.4) and 32.7 months (95%CI 28.7 to “not reached”, respectively).

Conclusions
Patients receiving combination therapy with tofacitinib or bDMARDs had higher disease activity scores at index than patients receiving monotherapy. Monotherapy with tofacitinib or bDMARDs, and combination therapy with tofacitinib or bDMARDs demonstrated similar treatment effectiveness and persistence, respectively.

Key Points• This study provides real-world evidence regarding effectiveness, treatment persistence, and treatment patterns, among patients with rheumatoid arthritis (RA) treated with monotherapy or combination therapy tofacitinib.• The study suggests that monotherapy and combination therapy tofacitinib is an effective intervention in RA with persistence and effectiveness comparable to bDMARDs.
Local and regional politicians’ considerations of newly arrived migrants’ health in political decision-making: a public health study in northern Sweden
Authors: Svanholm Sara , Carlerby Heidi , Viitasara Eija 
Published: August 2021

Abstract
Background and aim
Early action is important for promoting newly arrived migrants’ health. Politicians are major actors in decision-making that affects health outcomes in the population. Therefore, the aim of this study was to explore local and regional politicians’ considerations of newly arrived migrants’ health in political decision-making: whether politicians reflect on or discuss the effects of decision-making specifically on newly arrived migrants’ health, whether considerations differ between municipality and regional politicians, and how knowledge and attitudes are associated with such considerations.

Subject and methods
A cross-sectional quantitative study was conducted. A total of 667 municipality and regional politicians from northern Sweden responded to a questionnaire developed based on interviews with politicians. Bivariate analyses were performed using χ2 tests, the independent samples t-test, and the Wilcoxon signed-rank test. Multivariate analysis was performed using binary logistic regression.

Results
Politicians considered the effects on newly arrived migrants’ health significantly less frequently than those on the total population’s health. Regional politicians discussed such effects more often than municipality politicians. Knowledge (odds ratio [OR] = 1.343), attitude (OR = 5.962), previous experience working on public health issues (OR = 1.784), and female gender (OR = 1.787) were positively associated with considering effects on newly arrived migrants’ health in decision-making.

Conclusion
Politicians play important roles in health promotion, and most consider health-related effects in their decision-making. However, about a third do not consider such effects. General health-related knowledge and attitude are important factors that could be affected or changed during political assignments.
Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein
Authors: Wang Chen-Long , Li Jing-Chi , Zhou Ci-Xiang , Ma Cheng-Ning , Wang Di-Fei , Wo Lu-Lu , He Ming , Yin Qianqian , He Jian-Rong , Zhao Qian 
Published: August 2021

Abstract
Purpose
Tumor metastasis is the main cause of death from breast cancer patients and cell migration plays a critical role in cancer metastasis. Recent studies have shown long non-coding RNAs (lncRNAs) play an essential role in the initiation and progression of cancer. In the present study, the role of an LncRNA, Rho GTPase Activating Protein 5- Antisense 1 (ARHGAP5-AS1) in breast cancer was investigated.

Methods
RNA sequencing was performed to find out dysregulated LncRNAs in MDA-MB-231-LM2 cells. Transwell migration assays and F-actin staining were utilized to estimate cell migration ability. RNA pulldown assays and RNA immunoprecipitation were used to prove the interaction between ARHGAP5-AS1 and SMAD7. Western blot and immunofluorescence imaging were used to examine the protein levels. Dual luciferase reporter assays were performed to evaluate the activation of TGF-β signaling.

Results
We analyzed the RNA-seq data of MDA-MB-231 and its highly metastatic derivative MDA-MB-231-LM2 cell lines (referred to as LM2) and identified a novel lncRNA (NR_027263) named as ARHGAP5-AS1, which expression was significantly downregulated in LM2 cells. Further functional investigation showed ARHGAP5-AS1 could inhibit cell migration via suppression of stress fibers in breast cancer cell lines. Afterwards, SMAD7 was further identified to interact with ARHGAP5-AS1 by its PY motif and thus its ubiquitination and degradation was blocked due to reduced interaction with E3 ligase SMURF1 and SMURF2. Moreover, ARHGAP5-AS1 could inhibit TGF-β signaling pathway due to its inhibitory role on SMAD7.

Conclusion
ARHGAP5-AS1 inhibits breast cancer cell migration via stabilization of SMAD7 protein and could serve as a novel biomarker and a potential target for breast cancer in the future.
Revisiting Piezoelectric Sensor Calibration Methods Using Elastodynamic Body Waves
Authors: Wu Rui , Selvadurai Paul A. , Chen Chaojian , Moradian Omid 
Published: August 2021

AbstractThe application of absolutely calibrated piezoelectric (PZT) sensors is increasingly used to help interpret the information carried by radiated elastic waves of laboratory/in situs acoustic emissions (AEs) in nondestructive evaluation. In this paper, we present the methodology based on the finite element method (FEM) to characterize PZT sensors. The FEM-based modelling tool is used to numerically compute the true Green’s function between a ball impact source and an array of PZT sensors to map active source to theoretical ground motion. Physical-based boundary conditions are adopted to better constrain the problem of body wave propagation, reflection and transmission in/on the elastic medium. The modelling methodology is first validated against the reference approach (generalized ray theory) and is then extended down to 1 kHz where body wave reflection and transmission along different types of boundaries are explored. We find the Green’s functions calculated using physical-based boundaries have distinct differences between commonly employed idealized boundary conditions, especially around the anti-resonant and resonant frequencies. Unlike traditional methods that use singular ball drops, we find that each ball drop is only partially reliable over specific frequency bands. We demonstrate, by adding spectral constraints, that the individual instrumental responses are accurately cropped and linked together over 1 kHz to 1 MHz after which they overlap with little amplitude shift. This study finds that ball impacts with a broad range of diameters as well as the corresponding valid frequency bandwidth, are necessary to characterize broadband PZT sensors from 1 kHz to 1 MHz.
Is Dance Closer to Physical Activity or Spirituality? A Philosophical Exploration
Authors: Gronek Piotr , Gronek Joanna , Karpińska Aleksandra , Dobrzyńska Małgorzata , Wycichowska Paulina 
Published: August 2021

AbstractDancing is inevitably associated with kinesthetics of the body, including movements, gestures, poses, jumps, turnings, transferring body weight, etcetera. Thus, dance is a manifestation of an amateur or the skilled behavior of a fully trained athletic performance. At the same time, dance is accompanied by emotions as an effect of expression, narration of choreography. Dance is also pre-planned and designed to produce numerous styles and techniques. It is a unique type of improvisation. However, in certain situations, styles and techniques that will be discussed below, the dancing body can bring the dancer closer to his/her emotionality and even spirituality. Thus, the aim of this philosophical exploration is to analyze the impact of spirituality on dance performance.
Rockfall susceptibility and runout in the Valley of the Kings
Authors: Marija Lukovic , Martin Ziegler , Jordan Aaron , Matthew Perras 
Published: August 2021

AbstractThe UNESCO world heritage site Valley of the Kings or Wadi el-Moluk (وادي الملوك) near Luxor, Egypt, hosts unique burial places of Egyptian kings and royals from the New Kingdom (c. 1539–1075 BCE) and attracts about 0.5 to 2 million tourists per year. Very steep to subvertical cliffs of Thebes Limestone surround the Valley of the Kings. The rock mass is cut by frequent joints and faults making the cliff walls prone to rockfalls. However, only few rockfall debris are found in the valley, likely due to natural remobilisation by flood events and artificial clearings and excavation works that rendered the natural debris cover over the millennia. This work focuses on rockfall susceptibility and runout and makes use of new high-resolution landscape surface models utilising terrestrial laser scanning. We investigated rockfall release areas by exploring rock mass fractures at 23 cliff segments and analysed the kinematics of potential rockfalls. Furthermore, we estimated potential rockfall deposition areas with CONEFALL supported by nine numerical simulations of single rockfall events using Rockyfor3D. We found that nearly 4500 m2 (26%) of the public walking paths and 24 out of 64 tomb entrance areas locate within potential rockfall runout zones.
Elemental and Thermo-gravimetric Characterization of Trace Metals in Leaves and Soils as Bioindicators of Pollution in Kyiv City
Authors: Tarik Mohamed , Hoffmann Michael , Shmarin Sergey , Patil Ajay Bhagwan , Ludwig Christian 
Published: August 2021

AbstractIn this study, leaf and soil samples were used as bio-monitors for different alkali and heavy metals at six different locations in Kyiv city. Using x–y plots of the inductively coupled plasma optical emission spectroscopy (ICP-OES) data measured the discrepancy level in elemental composition between the different investigated areas; the correlation between the concentrations in tree leaves and the samples from the surrounding soils were investigated. While the concentration of essential mineral elements and metals was found to be similar in several leaf and soil samples, in other samples, their concentration spread up to more than one order of magnitude. The concentration of metals was found to be higher in soil samples than in leaves. Thermo-gravimetric analysis (TGA) data helped to further characterize both types of samples. The metal removal during the incineration of the leaves was investigated by coupling a thermo-gravimetric analyzer to an inductively coupled plasma optical emission spectrometer (TGA-ICP-OES). The release of Cd, K, Na, Pb, and Zn during incineration at temperatures up to 960 °C was online monitored, and some insights were drawn about the behavior of such metals and the chemistry involved in the volatilization process.
A Practical Speed Loss Prediction Model at Arbitrary Wave Heading for Ship Voyage Optimization
Authors: Lang Xiao , Mao Wengang 
Published: August 2021

AbstractThis paper proposes a semi-empirical model to predict a ship’s speed loss at arbitrary wave heading. In the model, the formulas that estimate a ship’s added resistance due to waves attacking from different heading angles have been further developed. A correction factor is proposed to consider the nonlinear effect due to large waves in power estimation. The formulas are developed and verified by model tests of 5 ships in regular waves with various heading angles. The full-scale measurements from three different types of ships, i.e., a PCTC, a container ship, and a chemical tanker, are used to validate the proposed model for speed loss prediction in irregular waves. The effect of the improved model for speed loss prediction on a ship’s voyage optimization is also investigated. The results indicate that a ship’s voyage optimization solutions can be significantly affected by the prediction accuracy of speed loss caused by waves.