bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance Investigation of Cooperative Green Underground Wireless Systems
Authors: Kanthavel R , Dhaya R 
Published: September 2021

Abstract
Diversity is a well-known strategy for preventing the negative consequences of fading in Underground wireless communication systems. Space diversity is one of numerous diversity approaches that uses multiple antennas for transmitting and receiving.. Accomplishing spatial diversity in a versatile unit calls for the utilization of different antennas, which, thusly, builds its equipment multifaceted nature and size. Appropriated spatial diversity: versatile units which are circulated in various topographical areas produce numerous correspondence ways. Down to earth execution of dispersed spatial variety necessitates a type of participation among the portable units. A cooperative diversity approach with a sources, multiple transfer, and a purpose is considered in this research. Due to the failure of traditional choice of combination algorithms to consider for the impact of source-to-relay connections in the error analysis of cooperative multiplicity networks, their effectiveness is suboptimal. We have proposed in this research a novel plan which receives another determination system at the goal subsequently giving ideal execution. The start to finish image blunder likelihood (SEP) of a proposed choice technique plot for such a framework, with unravel and forward transferring and parallel stage move entering in a level Rayleigh blurring condition, is broke down. This platform's effectiveness has been investigated using a methodology. This technique was evaluated to a non-cooperative selection combined approach and a standard selection combined strategy. The suggested methodology gives a large sign to-commotion proportion improvement over traditional decision joining and noncooperation, according the results.
The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity
Authors: Paradis Marie , Kucharowski Nicole , Edwards Gabriela , Palacios Santiago Maya , Meyer Christian , Stümpges Birgit , Jamitzky Isabell , Kalinowski Julia , Thiele Christoph , Bauer Reinhard , Paululat Achim , Sellin Julia , Bülow Margret 
Published: September 2021

Abstract
Dynamic contacts are formed between endoplasmic reticulum (ER) and mitochondria that enable the exchange of calcium and phospholipids. Disturbed contacts between ER and mitochondria impair mitochondrial dynamics and are a molecular hallmark of Parkinson’s disease. Cystein-rich with EGF-like domain (Creld) are ER-proteins associated with atrioventricular septal defects, but human CRELD1 is also a poorly characterized risk gene for Parkinson’s disease. Here we show that Creld is required for ER-mitochondria communication. Loss of Creld leads to mitochondrial hyperfusion and reduced ROS signaling in Drosophila melanogaster, Xenopus tropicalis and human cells. We found that reduced respiratory complex I activity lowers hydrogen peroxide levels, which disturbs neuronal activity and leads to impaired locomotion in Creld mutants. Our study presents a new paradigm of neuron dysfunction as a result of impaired ER-mitochondria communication and a new model for Parkinson’s disease.
Fully Coupled Numerical Methods for Elastohydrodynamic Lubrication Line Contact Problems by the High Order Finite Difference Methods
Authors: SHEN QUAN , Wu Bing , XIAO GUANGWEN 
Published: September 2021

Abstract
In this paper a high order finite difference method is constructed to solve the elastohydrodynamic lubrication line contact problems, whose cavitation condition is handled by the penalty method. The highly nonlinear equations from the discretization of the high order finite difference method are solved by the trust-region dogleg algorithm. In order to reduce the numerical dissipation and dispersion brought by the high order upwind finite difference scheme, a high order biased upwind finite difference scheme is also presented. Our method is found to achieve more accurate solutions using just a small number of nodes compared to the multilevel methods combined with the lower order finite difference method.
Study on the Influence of Rainfall Infiltration on the High rock Slope of Open-pit Mine Stability using a New Nonlinear Strength Reduction Method
Authors: Zhou Tianbai , Zhang Lingfan , Cheng Jian , Wang Jianming , Zhang Xiaoyu , Li Maoyuan 
Published: September 2021

Abstract
Due to long-term mining, a series of high and steep rock slopes have been formed in the open-pit mine. For high rock slopes, rainfall infiltration is the main cause of landslide. Therefore, the stability analysis of high rock slope under rainfall has become a key issue in the open-pit mine engineering. In this work, aiming at the high stress condition of high rock slope, the instantaneous internal friction angle and instantaneous cohesion of rock mass under different stress states are deduced, and the a nonlinear strength reduction method for high rock slope is established according to the relationship between normal stress and shear stress of rock mass under the Hoke-Brown criterion. The numerical calculation results show that the factor of safety (FOS) for high rock slope calculated by the proposed method is more reasonable. Taking the southwest slope of Dagushan Iron Mine as the research background, the safety factors of high rock slope under different rainfall conditions are calculated by COMSOL Multiphysics. And the stability analysis of high rock slope in open-pit mine under rainfall are carried out.
Network Flow and Flood Routing Model for Water Resources Optimization
Authors: Tahiri Ayoub , Che Daniel , Ladevèze David , Chiron Pascale , Archimède Bernard 
Published: September 2021

Abstract
Real-time management of hydraulic systems composed of multi-reservoir involves conflicting objectives. Its representation requires complex variables to consider all the systems dynamics. Interfacing simulation model with optimization algorithm permits to integrate flow routing into reservoir operation decisions and consists in solving separately hydraulic and operational constraints, but it requires that the water resource management model is based on an evolutionary algorithm. Considering channel routing in optimization algorithm can be done using conceptual models such as the Muskingum model. However, the structure of algorithms based on a network flow approach, inhibits the integration of the Muskingum model in the approach formulation. In this work, a flood routing model, corresponding to a singular form of the Muskingum model, constructed as a network flow is proposed, so that it can be easily integrated into the water management problem. A genetic algorithm is involved for the calibration of the model. The proposed flood routing model was applied on the standard Wilson test and on a 40 km reach of the Arrats river (southwest of France). The results were compared with the results of the Muskingum model. Finally, operational results for a water resource management system including this model are illustrated on a rainfall event.
Optical Mapping of the Fusarium oxysporum f. sp. melongenae Genome
Authors: Ates Duygu , Altinok Hacer Handan , Tanyolaç Bahattin 
Published: September 2021

Abstract
Optical mapping approaches are widely preferred and applied in different branches of genomic studies because of their accuracy, low cost, and high efficiency. In the current study, a sequence orientation of the Fusarium oxysporum f. sp. melongenae (FOMG) genome that is deposited in GenBank NCBI under accession number MPIL00000000 was used as the reference genome, which we checked with Bionano Genomics (BNG) optical mapping approaches. BNG optical mapping produced 103 contigs, the longest of which was 3.05 Mb. The N50 value of BNG contigs is 0.85 Mb. The sequences of the FOMG reference genome and BNG optical map mainly match each other. Results obtained in the current study indicate that BNG optical mapping can be used to construct complete and gapless assemblies of the FOMG genome. It also can be applied to validate a previous genome assembly.
Static And Fatigue Tensile Properties of High-Strength Polyacrylonitrile (PAN)-Based Carbon And Electrical-Class Glass Hybrid Fiber-Reinforced Epoxy Matrix Composites
Authors: Naito Kimiyoshi 
Published: September 2021

Abstract
The static and fatigue tensile properties of high-strength polyacrylonitrile (PAN)-based carbon (IMS60) and electronic (E)-class glass (E-glass) hybrid fiber-reinforced epoxy matrix composites (HFRPs) were investigated. The fiber orientations of the HFRP specimens were set to unidirectional with [(0(IMS60))/(0(E−glass))]S (subscript S means symmetry and [(0(IMS60))/(0(E−glass))/(0(E−glass))/(0(IMS60))]), [(0(E−glass))/(0(IMS60))]S, [(0(E−glass))/(0(IMS60))2]S, [(0(E−glass))/(0(IMS60))3]S, [(0(E−glass))/(0(IMS60))5]S, [(0(E−glass))2/(0(IMS60))]S, [(0(E−glass))3/(0(IMS60))]S, and [(0(E−glass))5/(0(IMS60))]S. Under static loading for the [(0(IMS60))/(0(E−glass))]S, [(0(E−glass))/(0(IMS60))]S, [(0(E−glass))/(0(IMS60))2]S, [(0(E−glass))/(0(IMS60))3]S, and [(0(E−glass))/(0(IMS60))5]S HFRP specimens, the stress applied to the specimen was almost linearly proportional to the strain until failure. However, the tensile stress–strain curves of the [(0(E−glass))2/(0(IMS60))]S, [(0(E−glass))3/(0(IMS60))]S, and [(0(E−glass))5/(0(IMS60))]S HFRP specimens had a complicated shape (jagged trace). The Weibull statistical distributions of the tensile strength values were also examined. The Weibull moduli for the [(0(E−glass))/(0(IMS60))]S, [(0(E−glass))/(0(IMS60))2]S, [(0(E−glass))/(0(IMS60))3]S, [(0(E−glass))/(0(IMS60))5]S, [(0(E−glass))2/(0(IMS60))]S, [(0(E−glass))3/(0(IMS60))]S, and [(0(E−glass))5/(0(IMS60))]S HFRP specimens were higher than those for the mono carbon fiber-reinforced epoxy (CFRP) and glass fiber-reinforced epoxy (GFRP) specimens. Under fatigue loading, the fatigue properties of the HFRP specimens showed CFRP-dominant behaviour at high stress levels and GFRP-dominant behaviour at low stress levels. The fatigue properties of the HFRP specimens increased with increasing volume fraction of CFRP in the following order: ([(0(E−glass))/(0(IMS60))5]S > [(0(E−glass))/(0(IMS60))3]S > [(0(E−glass))/(0(IMS60))2]S > [(0(IMS60))/(0(E−glass))]S > [(0(E−glass))/(0(IMS60))]S > [(0(E−glass))2/(0(IMS60))]S > [(0(E−glass))3/(0(IMS60))]S > [(0(E−glass))5/(0(IMS60))]S).
Growth hormone receptor controls adipogenic differentiation of chicken bone marrow mesenchymal stem cells by affecting mitochondrial function
Authors: Zhao Changbin , Hu Bowen , Wei Haohui , Luo Wen , Zhao Yongxia , Liang Jinping , Nie Qinghua , Luo Qingbin , Zhang Dexiang , Zhang Xiquan , Li Hongmei 
Published: September 2021

Abstract
Background

Growth hormone receptor (GHR), a member of the type I cytokine receptor family, activates several downstream signaling pathways after binding to growth hormone (GH) to regulate cell growth and development. However, in poultry, the relations among the GHR gene, mitochondrial function, and adipocyte differentiation remain unclear.
Methods

In this study, we used sex-linked dwarf (SLD) chickens and normal chickens as research objects and overexpression or knockdown of GHR in bone mesenchymal stem cells (BMSCs) at the stage of adipogenic differentiation, to investigate the effects of the GHR gene on mitochondrial biogenesis, mitochondrial function and adipogenic differentiation of BMSCs.
Results

Yellow bone marrow in SLD chickens was higher than that in normal chickens, and lipid droplets and triglyceride content also increased in SLD bone marrow tissue. Mitochondrial biogenesis and function in BMSCs were compared between SLD and normal chickens, mitochondrial membrane potential decreased, mitochondrial ROS (mtROS) and ATP contents increased. Expression of genes associated with mitochondrial biogenesis and function, including ND1, ND2, CYTB, COX1, COX2, ATP6, ATP8, PGC1α, NRF1, and TFAM, also increased in BMSCs of SLD chickens. In addition, GHR was overexpressed and knocked down in chicken BMSCs to verify results in vitro. Overexpression of GHR increased mitochondrial membrane potential but decreased mtROS and ATP contents, oxidative phosphorylation complex enzyme activity, and mitochondrial number. Expression of genes associated with mitochondrial biogenesis and function was also repressed during adipogenic differentiation in chicken BMSCs. After overexpression of GHR, changes in adipogenic differentiation capacity of chicken BMSCs were also examined, and expression of genes associated with adipogenic differentiation, including PPARγ, C/EBPα, and C/EBPβ, decreased. Triglyceride production and number of lipid droplets (oil red O staining) also decreased after GHR overexpression. With knockdown of GHR, opposite results were observed.
Conclusions

GHR inhibited adipogenic differentiation of chicken BMSCs by suppressing mitochondrial function. This suppression might explain the clinical manifestation of severe fat deposition in SLD chickens.
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo
Authors: liu yuhan , zhou jiabin , luo yingying , li jinxiao , shang luorui , zhou fangyuan , yang shenglan 
Published: September 2021

Abstract
Background
Honokiol (HKL) has been reported to ameliorate lipopolysaccharide (LPS)-induced acute lung injury (ALI). However, its potential mechanism imparting the protective effects remains unclear. In this study, the protective mechanism of HKL on LPS-induced ALI was explored in vivo and in vitro.
Methods
In vivo, the SD rats were intratracheally instilled with LPS (5 mg/kg) to establish an acute lung injury model and then treated with HKL (1.25/2.5/5 mg/kg) or ML385 (30 mg/kg) intraperitoneally. In vitro, the human bronchial epithelial cell line (BEAS-2B) was stimulated with LPS and ATP to induce pyroptosis and treated with HKL (12.5/25/50 µM). Small interfering RNA (siRNA) technique was used to knockdown Nrf2 in BEAS-2B cells. The protein and mRNA expression levels of Nrf2, HO-1, NLRP3, ASC, CASP1, and GSDMD in cells and lung tissues were detected by western blot and real time-PCR. The expression levels of interleukin (IL)-1β, IL-18, MPO, MDA, and SOD in bronchoalveolar lavage fluid (BALF) and supernatant were determined by ELISA. The degree of pathological injury of lung tissue was evaluated by H&E staining.
Results
The results showed that HKL could alleviate the oxidative stress and inflammatory responses by regulating the levels of MPO, MDA, SOD, IL-1β, IL-18 in supernatant. And HKL inhibited the expression levels of NLRP3, ASC, CASP1, GSDMD via activation of Nrf2 in BEAS-2B cells. Further studies revealed that HKL could attenuate the pathological injury in LPS-induced ALI rats and the molecular mechanism was consistent with the results in vitro.
Conclusions
Our study demonstrated that HKL could alleviate LPS-induced ALI by reducing the oxidative stress and inhibiting NLRP3 inflammasome-mediated pyroptosis, which was partly dependent on the Nrf2 activation.
The Small Molecule Components of Human Synovial Fluid and Bovine Calf Serum that Correlate with Cobalt Chrome (CoCrMo) Wear
Authors: Jaggard Matthew , Stevenson Harriet , Boulange Claire , Graca Goncalo , Akhbari Pouya , Vaghela Uddhav , Bhattacharya Rajarshi , Williams Horace , Lindon John , Cann Philippa , Gupte Chinmay 
Published: September 2021

Abstract
Background:Implant wear in joint replacements is influenced by the chemical and physical properties of human synovial fluid (HSF). In vitro testing for implant wear uses 25% weight bovine calf serum (25BCS) to substitute for HSF, due to similar rheology and total protein content. However, previous studies have shown differences in the macromolecular composition. We aimed to evaluate the differences in small molecule composition between fluids and correlate these differences with their effects on implant material wear.Methods:HSF was harvested from osteoarthritis patients undergoing primary knee replacement (n=14). Nuclear magnetic resonance (NMR) spectroscopy with linear regression modelling analysed the metabolites present in HSF and commercially sourced 25BCS and investigated the differences. Wear properties of the fluids were evaluated using a validated quantitative laboratory bench-test utilising a cobalt/chromium/molybdenum (CoCrMo) ball oscillating against a CoCrMo disc and analysing the resulting wear scar. The variation in metabolite levels in both HSF and 25BCS was correlated to the wear properties of the fluids.Results:Differences in the levels of metabolites, lipids, and glycosaminoglycans (GAG) were observed between HSF and 25BCS: significance was confirmed by O-PLS-DA (p<0.05). The wear of CoCrMo was found to strongly correlate with the macromolecules GAG and proteins that potentially bind to glucose and citrate. Conclusions:The small molecule concentration differences between the fluids questions the validity of 25BCS as a model for wear analysis. The demonstration of variable metabolites present in HSF which correlate with material wear has implications for implant failure and targeted therapeutic manipulation of these metabolites. Trial Registration:Ethical approval was granted by the NRES Committee London, Chelsea, UK on the 12th May 2015. The study was performed in accordance with the ethical standards in the 1964 Declaration of Helsinki.
A Simple Fluorescent Aptasensing Platform Based on Graphene Oxide for Dopamine Determination
Authors: Teniou Ahlem , rhouati amina , Catanante Gaëlle 
Published: September 2021

Abstract
Dopamine (DA) is a catecholamine neurotransmitter playing an important role in different biological functions including central nervous, renal, cardiovascular, and hormonal systems. The sensitive and selective detection of this neurotransmitter plays a key role in the early diagnosis of various diseases related to abnormal levels of dopamine. Therefore, it is of great importance to explore rapid, simple, and accurate methods for detection of dopamine with high sensitivity and specificity. We propose in this work, a fluorescent aptasensor based on graphene oxide (GO) as a quencher, for the rapid determination of dopamine. The principle of this aptasensor is based on fluorescence resonance energy transfer (FRET), where GO was used as energy donor, and a carboxyfluorescein (FAM)-labeled aptamer as acceptor. In the absence of DA, FAM-aptamer was adsorbed on the surface of GO through π-π stacking interactions between nucleotide bases and the carbon network, leading to a weak FRET and a quenching of the FAM fluorescence. However, by adding the target, the aptamer undergoes a conformational change to bind to DA with high affinity, resulting in a fluorescence recovery. Under the optimal experimental conditions, the fluorescence recovery was linearly proportional to the concentration of DA in the range of 3-1680 nM, with a limit of detection of 0.031 nM. Moreover, the developed assay exhibited minor response in the presence of various interferents and it revealed a satisfactory applicability in human serum samples.
Access to Facility-Based Childbirth: Women’s Experience on Enablers and Obstacles to the Utilisation of Waiting Mothers’ Shelters in Rural Zimbabwe
Authors: Muchabveyo Brenda 
Published: September 2021

Abstract
This article explores experiences and perceptions of women concerning the utilising a waiting mothers’ shelter at Bonda Mission Hospital in the Manicaland province of Zimbabwe. It draws on a phenomenological qualitative research design. This incorporated in-depth interviews and key informant interviews with purposively selected fifteen women who have used the waiting mothers’ shelter since 2015 and eight healthcare practitioners respectively. The paper is guided by Alfred Schutz’s (1972) social phenomenology. While the findings reveal that most women acknowledged the importance of waiting mothers’ shelters in improving access to skilled birth attendance and maternal health outcomes, there are still factors that militate the use of such innovations. Several socio-cultural and economic factors such as constrained decision making among women, mistreatment and lack of privacy in the shelters are some of the deterrent factors. The article concludes that, although waiting mothers’ shelters are facilities proven to be beneficial in rural communities, they continually face the risk of not being used. There is a need for a multi-stakeholder approach to address the barriers that deter women from utilising the waiting mothers’ shelters and improve access to facility-based delivery, access to skilled birth attendants and enhance the maternal health outcomes in rural communities in Zimbabwe.
The Technical Impacts of the Carbon Tax in China
Authors: Chen Shuyang 
Published: September 2021

Abstract
Despite the significant impacts of technology on the socioeconomic effects of climate policies, many previous researchers neglected the induced technical impacts and thus resulted in biased evaluations of climate policies. Hence, it is important that the induced technology should be endogenized in the policy evaluation framework. In this paper, I attempt to use a Computable General Equilibrium (CGE) model to quantify the technical impacts of the Chinese carbon tax. The technical impacts are denoted by the induced technological change (ITC), which is a function of the energy-use efficiency (EUE), energy-production efficiency (EPE), and nonenergy-production efficiency (ENE). The carbon tax will increase the energy cost share because the of the internalisation of the abatement costs. This paper empirically shows that the carbon tax will decrease the energy cost share and production efficiency but increase the energy use and nonenergy production efficiency. Overall, the carbon tax will promote the technological development, compared to the baseline scenario. In addition to the policy effects of the tax, the ITC will decrease the energy use and production efficiency but increase the nonenergy production efficiency. The ITC will increase the RGDP, decrease the household welfare, and increase the average social cost of carbon (ASCC). To summarise, despite that the carbon tax will decrease the welfare at the country and household level, the ITC of the carbon tax will increase the welfare at the country level but decrease the welfare at the household level. Under the ITC impacts, the emission abatement will become costlier.
How can we govern large-scale green infrastructure for multiple water security benefits?
Authors: Pecharroman Lidia Cano , Williams Christopher , Nylen Nell Green , Kiparsky Michael 
Published: September 2021

AbstractTraditional, limited purpose grey infrastructure has failed to address the world's interrelated water challenges. Improving water security will increasingly require more integrated responses. This paper examines large-scale green infrastructure (LSGI), planned natural or hybrid systems that materially affect water security at the watershed scale, as one such response. This paper examines key challenges for governing and financing LSGI, which hinder its broader use. We report on four case studies located in the United States where LSGI is being employed to improve water security. Through analysis of these case studies and related literature, we identify three themes important for LSGI governance: cost sharing, performance monitoring, and legitimization. First, we hypothesize that formal cost sharing based on the multiple benefits LSGI provides could enable wider adoption, but find that in these examples cost sharing is limited and informal. Second, our research suggests that expanding performance monitoring to encompass key secondary benefits could help clarify how the benefits and burdens of a project are distributed across stakeholders, facilitate cost sharing, and enhance project legitimacy. Finally, LSGI will require further legitimization – developing a broader perception that LSGI is an appropriate alternative or complement to grey infrastructure – to develop as a viable contributor to water security.