bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced misclosure of global sea-level budget with updated Tongji-Grace2018 solution
Authors: Wang Fengwei , Shen Yunzhong , Chen Qiujie , Sun Yu 
Published: September 2021

AbstractThe global sea-level budget is studied using the Gravity Recovery and Climate Experiment (GRACE) solutions, Satellite Altimetry and Argo observations based on the updated budget equation. When the global ocean mass change is estimated with the updated Tongji-Grace2018 solution, the misclosure of the global sea-level budget can be reduced by 0.11–0.22 mm/year compared to four other recent solutions (i.e. CSR RL06, GFZ RL06, JPL RL06 and ITSG-Grace2018) over the period January 2005 to December 2016. When the same missing months as the GRACE solution are deleted from altimetry and Argo data, the misclosure will be reduced by 0.06 mm/year. Once retained the GRACE C20 term, the linear trends of Tongji-Grace2018 and ITSG-Grace2018 solutions are 2.60 ± 0.16 and 2.54 ± 0.16 mm/year, closer to 2.60 ± 0.14 mm/year from Altimetry–Argo than the three RL06 official solutions. Therefore, the Tongji-Grace2018 solution can reduce the misclosure between altimetry, Argo and GRACE data, regardless of whether the C20 term is replaced or not, since the low-degree spherical harmonic coefficients of the Tongji-Grace2018 solution can capture more ocean signals, which are confirmed by the statistical results of the time series of global mean ocean mass change derived from five GRACE solutions with the spherical harmonic coefficients truncated to different degrees and orders.
Determining the microbial and chemical contamination in Ecuador’s main rivers
Authors: Vinueza Dayana , Ochoa-Herrera Valeria , Maurice Laurence , Tamayo Esteban , Mejía Lorena , Tejera Eduardo , Machado António 
Published: September 2021

AbstractOne major health issue is the microbial and chemical contamination of natural freshwater, particularly in Latin American countries, such as Ecuador, where it is still lacking wastewater treatment plants. This study analyzed the water quality in twelve rivers of Ecuador (Coastal, Andean, and Amazonian regions). All rivers showed levels ofE. coliand total coliforms above the maximum limit according to International and Ecuadorian legislations. The most polluted rivers were Zamora, Esmeraldas and Machángara. Also,E. colipathotypes were found in six rivers. Several physicochemical and metal parameters were detected in high levels, such as CODTOTAL(in eight rivers), TSS (in six rivers), TS (in two rivers), Al (in nine rivers), Zn (in eight rivers), Pb (in three rivers), Cu (in three rivers), Fe (in two rivers), and Mn (in Machángara River). Our results agree with other studies in Latin America (such as Colombia, Brazil, and Peru) reporting similar contamination in water resources used for agriculture, livestock, and human consumption. Overall, Guayas, Guayllabamba, and Machángara Rivers showed the highest levels of physicochemical parameters (such as CODTOTALand TSS) and metal concentrations (such as copper, zinc, aluminum, iron, and manganese). Further studies should evaluate contamination sources and public health impact.
Novel lipophosphonoxin-loaded polycaprolactone electrospun nanofiber dressing reduces Staphylococcus aureus induced wound infection in mice
Authors: Do Pham Duy Dinh , Jenčová Věra , Kaňuchová Miriam , Bayram Jan , Grossová Ivana , Šuca Hubert , Urban Lukáš , Havlíčková Kristýna , Novotný Vít , Mikeš Petr , Mojr Viktor , Asatiani Nikifor , Košťáková Eva Kuželová , Maixnerová Martina , Vlková Alena , Vítovská Dragana , Šanderová Hana , Nemec Alexandr , Krásný Libor , Zajíček Robert , Lukáš David , Rejman Dominik , Gál Peter 
Published: September 2021

AbstractActive wound dressings are attracting extensive attention in soft tissue repair and regeneration, including bacteria-infected skin wound healing. As the wide use of antibiotics leads to drug resistance we present here a new concept of wound dressings based on the polycaprolactone nanofiber scaffold (NANO) releasing second generation lipophosphonoxin (LPPO) as antibacterial agent. Firstly, we demonstrated in vitro that LPPO released from NANO exerted antibacterial activity while not impairing proliferation/differentiation of fibroblasts and keratinocytes. Secondly, using a mouse model we showed that NANO loaded with LPPO significantly reduced the Staphylococcus aureus counts in infected wounds as evaluated 7 days post-surgery. Furthermore, the rate of degradation and subsequent LPPO release in infected wounds was also facilitated by lytic enzymes secreted by inoculated bacteria. Finally, LPPO displayed negligible to no systemic absorption. In conclusion, the composite antibacterial NANO-LPPO-based dressing reduces the bacterial load and promotes skin repair, with the potential to treat wounds in clinical settings.
Genetic profiles of Barrett’s esophagus and esophageal adenocarcinoma in Japanese patients
Authors: Tokunaga Mamoru , Okimoto Kenichiro , Akizue Naoki , Ishikawa Kentaro , Hirotsu Yosuke , Amemiya Kenji , Ota Masayuki , Matsusaka Keisuke , Nishimura Motoi , Matsushita Kazuyuki , Ishikawa Tsubasa , Nagashima Ariki , Shiratori Wataru , Kaneko Tatsuya , Oura Hirotaka , Kanayama Kengo , Ohta Yuki , Taida Takashi , Saito Keiko , Matsumura Tomoaki , Chiba Tetsuhiro , Mochizuki Hitoshi , Arai Makoto , Kato Jun , Ikeda Jun-ichiro , Omata Masao , Kato Naoya 
Published: September 2021

AbstractThe genetic characteristics of Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) in the Japanese population is unclear. This study aims to investigate the genetic characteristics from nondysplastic BE (NDBE) to early EAC in Japan. Clinical information was collected. Moreover, the genetic profile of NDBE without concurrent dysplasia, early EAC, and surrounding BE were also investigated using endoscopic biopsy samples and formalin-fixed, paraffin-embedded specimens from Japanese patients by targeted next-generation sequencing. Immunohistochemical staining for p53 was also performed for EAC lesions. Targeted NGS was performed for 33 cases with 77 specimens. No significant difference exists in the NDBE group between the number of putative drivers per lesion in the short-segment Barrett’s esophagus (SSBE) and long-segment Barrett’s esophagus (LSBE) [0 (range, 0–1) vs. 0 (range, 0–1).p = 1.00].TP53putative drivers were found in two patients (16.7%) with nondysplastic SSBE.TP53was the majority of putative drivers in both BE adjacent to EAC and EAC, accounting for 66.7% and 66.7%, respectively. More putative drivers per lesion were found in the EAC than in the NDBE group [1 (range, 0–3) vs. 0 (range, 0–1).p < 0.01]. The genetic variants ofTP53in the Japanese early EAC were similar to those in western countries. However,TP53putative drivers were detected even in Japanese patients with nondysplastic SSBE. This is significant because such nondysplastic SSBE might have higher risk of progressing to high-grade dysplasia or EAC. The risks of progression may not be underestimated and appropriate follow-ups may be necessary even in patients with SSBE.Trial registration:This study was registered at the University Hospital Medical Information Network (UMIN000034247).
Dynamic stochastic joint expansion planning of power systems, natural gas networks, and electrical and natural gas storage
Authors: Gholami Arash , Nafisi Hamed , Askarian Abyaneh Hossein , Jahanbani Ardakani Ali 
Published: September 2021

AbstractOver the last decades, electricity generation from natural gas has substantially increased, mostly driven by low natural gas prices due to fracturing and lower extraction costs. The geographic distance between natural gas resources and load centers calls for a holistic tool for joint expansion of power systems and natural gas networks. In this paper, a Dynamic Stochastic Joint Expansion Planning (DSJEP) of power systems and natural gas networks is proposed to minimize the investment and operational costs of power and natural gas systems. Electrical and natural gas storage (ENGS) are considered as an option for decision‐makers in the DSJEP problem. The proposed approach takes into account long‐term uncertainties in natural gas prices and electric and natural gas demands through scenario realizations. In dynamic planning, more scenario needs more time for computation; therefore, scenario reduction is implemented to eschew unnecessary scenarios. The proposed formulation is implemented on a four‐bus electricity system with a five‐node natural gas network. To demonstrate the efficiency and scalability of the proposed approach, it is also tested on the IEEE 118‐bus system with a 14‐node natural gas network. The numerical results demonstrate that ENGS can reduce the total investment cost, up to 52% in the test cases, and operational cost, up to 3%. In this paper, co‐planning of power and natural gas systems considering natural gas and electrical storage is represented. Also, electrical and natural gas load growth uncertainties are taken into account to model the real situations. The purpose of the model is to minimize investing and operational costs.
Amphiphilic peroxo polyoxometalate as reaction control phase transfer catalyst for efficient epoxidation of olefins
Authors: Wu Jinghui , Zheng Hongwei , Wang Chi , Wang Xianze , Wang Xiaohong , Huo Mingxin 
Published: September 2021

AbstractA peroxo polyoxometalate‐based catalyst was synthesized, characterized, and employed as a catalyst in the epoxidation of olefins with hydrogen peroxide (H2O2). During the reaction, the insoluble catalyst became soluble and an emulsion formed to promote the epoxidation process. Then the emulsion broke and the catalyst precipitated for reuse easily.
Cooperative decentralized peer‐to‐peer electricity trading of nanogrid clusters based on predictions of load demand and PV power generation using a gated recurrent unit model
Authors: Lee Sangkeum , Jin Hojun , Vecchietti Luiz Felipe , Hong Junhee , Park Ki‐Bum , Son Pham Ngoc , Har Dongsoo 
Published: September 2021

AbstractThis paper presents an approach to the power management of nanogrid clusters assisted by a novel form of peer‐to‐peer (P2P) electricity trading. DC nanogrids have lower power loss in real time and are suitable for P2P trading. Here, cost of electricity for clusters involving different kinds of photovoltaic (PV) power production (as a secondary source) is reduced by a newly proposed P2P trading scheme. For power management of individual clusters, multi‐objective optimization is applied to minimize simultaneously total power consumption, grid power consumption, and total delay incurred locally by scheduling. The temporal surplus of self‐supplied PV power of a cluster can be sold through P2P trading to another cluster subjected to a temporal power shortage. In P2P trading, a cooperative game model is used for buyers and sellers to maximize their welfare. To increase P2P trading efficiency, prediction of load demand and PV power production is considered for power management of each cluster to resolve instantaneous imbalances between load demand and PV power production. A gated recurrent unit network is used to forecast future load demand and PV power production in nanogrid cluster could reduce electricity cost by 29.2%.
Sequential Use of Romiplostim after Eltrombopag for Refractory Thrombocytopenia in Hydrocarbon-Induced Myelodysplasia
Authors: Morales Luis F. , Miyara Santiago J. , Guevara Sara , Metz Christine N. , Shoaib Muhammad , Watt Stacey , Zafeiropoulos Stefanos , McCann-Molmenti Alexia , Hayashida Kei , Takegawa Ryosuke , Shinozaki Koichiro , Choudhary Rishabh C. , Brindley Elena C. , Nishikimi Mitsuaki , Kressel Adam M. , Alsalmay Yaser M. , Mazzotta Elvio A. , Cho Young Min , Aranalde Gabriel I. , Grande Daniel A. , Zanos Stavros , Shore-Lesserson Linda , Becker Lance B. , Molmenti Ernesto P. 
Published: September 2021

AbstractWe describe the clinical course of a 65-year-old male patient who suffered from hydrocarbon-induced myelodysplasia and was successfully treated with the thrombopoietin receptor agonist (TPO-RA), romiplostim. Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis, cytopenias, and increased risk of leukemic transformation. Here, we present a clinical vignette of MDS-associated thrombocytopenia refractory to first-line drugs as well as the TPO-RA, eltrombopag. To date, romiplostim is an U.S. Food and Drug Administration (FDA)-approved drug for idiopathic thrombocytopenic purpura and thrombocytopenia secondary to liver disease. Of note, currently the FDA advises against its use in MDS based on previous long-term safety concerns. Since the therapeutic options for thrombocytopenia in MDS patients are sparse, repurposing and reassessing romiplostim in this setting have been the focus of recent studies. At the time of writing, no published double-blind randomized clinical trials have conducted a head-to-head comparison between romiplostim and eltrombopag in thrombocytopenic MDS patients. To the best of our knowledge, for a thrombocytopenic patient in the setting of MDS, this is the first documented report of refractory clinical response after a 2-year use of eltrombopag in which replacement of treatment with romiplostim resulted in sustained physiological counts of thrombocytes within four weeks.
New Standards for Clinical Decision Support: A Survey of The State of Implementation
Authors: Taber Peter , Radloff Christina , Del Fiol Guilherme , Staes Catherine , Kawamoto Kensaku 
Published: September 2021

Summary
Objectives: To review the current state of research on designing and implementing clinical decision support (CDS) using four current interoperability standards: Fast Healthcare Interoperability Resources (FHIR); Substitutable Medical Applications and Reusable Technologies (SMART); Clinical Quality Language (CQL); and CDS Hooks.
Methods: We conducted a review of original studies describing development of specific CDS tools or infrastructures using one of the four targeted standards, regardless of implementation stage. Citations published any time before the literature search was executed on October 21, 2020 were retrieved from PubMed. Two reviewers independently screened articles and abstracted data according to a protocol designed by team consensus.
Results: Of 290 articles identified via PubMed search, 44 were included in this study. More than three quarters were published since 2018. Forty-three (98%) used FHIR; 22 (50%) used SMART; two (5%) used CQL; and eight (18%) used CDS Hooks. Twenty-four (55%) were in the design stage, 15 (34%) in the piloting stage, and five (11%) were deployed in a real-world setting. Only 12 (27%) of the articles reported an evaluation of the technology under development. Three of the four articles describing a deployed technology reported an evaluation. Only two evaluations with randomized study components were identified.
Conclusion: The diversity of topics and approaches identified in the literature highlights the utility of these standards. The infrequency of reported evaluations, as well as the high number of studies in the design or piloting stage, indicate that these technologies are still early in their life cycles. Informaticists will require a stronger evidence base to understand the implications of using these standards in CDS design and implementation.
Managing Pandemics with Health Informatics
Authors: Dixon Brian E. , Holmes John H. ,   Section Editors for the IMIA Yearbook Section on Managing Pandemics with Health Informatics
Published: September 2021

Summary
Objective: To summarize significant research contributions on managing pandemics with health informatics published in 2020.
Methods: An extensive search using PubMed and Scopus was conducted to identify peer-reviewed articles published in 2020 that examined health informatics systems used during the global COVID-19 pandemic. The selection process comprised three steps: 1) 15 candidate best papers were first selected by the two section editors; 2) external reviewers from internationally renowned research teams reviewed each candidate best paper; and 3) the final selection of three best papers was conducted by the editorial committee of the International Medical Informatics Association (IMIA) Yearbook.
Results: Selected best papers represent the important and diverse ways that health informatics supported clinical and public health responses to the global COVID-19 pandemic. Selected papers represent four groups of papers: 1) Use of analytics to screen, triage, and manage patients; 2) Use of telehealth and remote monitoring to manage patients and populations; 3) Use of EHR systems and administrative systems to manage internal operations of a hospital or health system; and 4) Use of informatics methods and systems by public health authorities to capture, store, manage, and visualize population-level data and information.
Conclusion: Health informatics played a critical role in managing patients and populations during the COVID-19 pandemic. Health care and public health organizations both leveraged available information systems and standards to rapidly identify cases, triage infected individuals, and monitor population trends. The selected best papers represent a fraction of the body of knowledge stemming from COVID-19, most of which is focused on pandemic response. Future work will be needed to help the world recover from the pandemic and strengthen the health information infrastructure in preparation for the next pandemic.
Human Factors and Organizational Issues in Health Informatics: Innovations and Opportunities
Authors: Marquard Jenna 
Published: September 2021

Objective: Human factors and ergonomics (HF/E) frameworks and methods are becoming embedded in the health informatics community. There is now broad recognition that health informatics tools must account for the diverse needs, characteristics, and abilities of end users, as well as their context of use. The objective of this review is to synthesize the current nature and scope of HF/E integration into the health informatics community.
Methods: Because the focus of this synthesis is on understanding the current integration of the HF/E and health informatics research communities, we manually reviewed all manuscripts published in primary HF/E and health informatics journals during 2020.
Results: HF/E-focused health informatics studies included in this synthesis focused heavily on EHR customizations, specifically clinical decision support customizations and customized data displays, and on mobile health innovations. While HF/E methods aimed to jointly improve end user safety, performance, and satisfaction, most HF/E-focused health informatics studies measured only end user satisfaction.
Conclusion: HF/E-focused health informatics researchers need to identify and communicate methodological standards specific to health informatics, to better synthesize findings across resource intensive HF/E-focused health informatics studies. Important gaps in the HF/E design and evaluation process should be addressed in future work, including support for technology development platforms and training programs so that health informatics designers are as diverse as end users.
Clinical Information Systems Research in the Pandemic Year 2020
Authors: Hackl W. O. , Hoerbst A. ,   Section Editors of the IMIA Yearbook Section on Clinical Information Systems
Published: September 2021

Summary
Objective: In this synopsis, we give an overview of recent research and propose a selection of best papers published in 2020 in the field of Clinical Information Systems (CIS).
Method: As CIS section editors, we annually apply a systematic process to retrieve articles for the International Medical Informatics Association Yearbook of Medical Informatics. For seven years now, we use the same query to find relevant publications in the CIS field. Each year we retrieve more than 2,400 papers which we categorize in a multi-pass review to distill a preselection of 15 candidate papers. External reviewers and yearbook editors then assess the selected candidate papers. Based on the review results, the IMIA Yearbook editorial board chooses up to four best publications for the section at a selection meeting. To get an overview of the content of the retrieved articles, we use text mining and term co-occurrence mapping techniques.
Results: We carried out the query in mid-January 2021 and retrieved a deduplicated result set of 2,787 articles from 1,135 different journals. We nominated 15 papers as candidates and finally selected four of them as the best papers in the CIS section. As in the previous years, the content analysis of the articles revealed the broad spectrum of topics covered by CIS research. Thus, this year we could observe a significant impact of COVID-19 on CIS research.
Conclusions: The trends in CIS research, as seen in recent years, continue to be observable. What was very visible was the impact of the Corona Virus Disease 2019 (COVID-19) pandemic, which has affected not only our lives but also CIS.
A Review of Recent Work in Transfer Learning and Domain Adaptation for Natural Language Processing of Electronic Health Records
Authors: Laparra Egoitz , Mascio Aurelie , Velupillai Sumithra , Miller Timothy 
Published: September 2021

Summary
Objectives: We survey recent work in biomedical NLP on building more adaptable or generalizable models, with a focus on work dealing with electronic health record (EHR) texts, to better understand recent trends in this area and identify opportunities for future research.
Methods: We searched PubMed, the Institute of Electrical and Electronics Engineers (IEEE), the Association for Computational Linguistics (ACL) anthology, the Association for the Advancement of Artificial Intelligence (AAAI) proceedings, and Google Scholar for the years 2018-2020. We reviewed abstracts to identify the most relevant and impactful work, and manually extracted data points from each of these papers to characterize the types of methods and tasks that were studied, in which clinical domains, and current state-of-the-art results.
Results: The ubiquity of pre-trained transformers in clinical NLP research has contributed to an increase in domain adaptation and generalization-focused work that uses these models as the key component. Most recently, work has started to train biomedical transformers and to extend the fine-tuning process with additional domain adaptation techniques. We also highlight recent research in cross-lingual adaptation, as a special case of adaptation.
Conclusions: While pre-trained transformer models have led to some large performance improvements, general domain pre-training does not always transfer adequately to the clinical domain due to its highly specialized language. There is also much work to be done in showing that the gains obtained by pre-trained transformers are beneficial in real world use cases. The amount of work in domain adaptation and transfer learning is limited by dataset availability and creating datasets for new domains is challenging. The growing body of research in languages other than English is encouraging, and more collaboration between researchers across the language divide would likely accelerate progress in non-English clinical NLP.