bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serglycin Is Involved in Adipose Tissue Inflammation in Obesity
Authors: Doncheva Atanaska I , Norheim Frode A , Hjorth Marit , Grujic Mirjana , Paivandy Aida , Dankel Simon N , Hertel Jens Kristoffer , Valderhaug Tone G , Böttcher Yvonne , Fernø Johan , Mellgren Gunnar , Dalen Knut T , Pejler Gunnar , Kolset Svein O 
Published: December 2021

Abstract
Chronic local inflammation of adipose tissue is an important feature of obesity. Serglycin is a proteoglycan highly expressed by various immune cell types known to infiltrate adipose tissue under obese conditions. To investigate if serglycin expression has an impact on diet-induced adipose tissue inflammation, we subjected Srgn+/+ and Srgn−/− mice (C57BL/6J genetic background) to an 8-wk high-fat and high-sucrose diet. The total body weight was the same in Srgn+/+ and Srgn−/− mice after diet treatment. Expression of white adipose tissue genes linked to inflammatory pathways were lower in Srgn−/− mice. We also noted reduced total macrophage abundance, a reduced proportion of proinflammatory M1 macrophages, and reduced formation of crown-like structures in adipose tissue of Srgn−/− compared with Srgn+/+ mice. Further, Srgn−/− mice had more medium-sized adipocytes and fewer large adipocytes. Differentiation of preadipocytes into adipocytes (3T3-L1) was accompanied by reduced Srgn mRNA expression. In line with this, analysis of single-cell RNA sequencing data from mouse and human adipose tissue supports that Srgn mRNA is predominantly expressed by various immune cells, with low expression in adipocytes. Srgn mRNA expression was higher in obese compared with lean humans and mice, accompanied by an increased expression of immune cell gene markers. SRGN and inflammatory marker mRNA expression was reduced upon substantial weight loss in patients after bariatric surgery. Taken together, this study introduces a role for serglycin in the regulation of obesity-induced adipose inflammation.
Divergent Genetic Regulation of Nitric Oxide Production between C57BL/6J and Wild-Derived PWD/PhJ Mice Controls Postactivation Mitochondrial Metabolism, Cell Survival, and Bacterial Resistance in Dendritic Cells
Authors: Snyder Julia P , Gullickson Soyeon K , del Rio-Guerra Roxana , Sweezy Andrea , Vagher Bay , Hogan Tyler C , Lahue Karolyn G , Reisz Julie A , D’Alessandro Angelo , Krementsov Dimitry N , Amiel Eyal 
Published: December 2021

Abstract
Dendritic cell (DC) activation is characterized by sustained commitment to glycolysis that is a requirement for survival in DC subsets that express inducible NO synthase (Nos2) due to NO-mediated inhibition of mitochondrial respiration. This phenomenon primarily has been studied in DCs from the classic laboratory inbred mouse strain C57BL/6J (B6) mice, where DCs experience a loss of mitochondrial function due to NO accumulation. To assess the conservation of NO-driven metabolic regulation in DCs, we compared B6 mice to the wild-derived genetically divergent PWD/PhJ (PWD) strain. We show preserved mitochondrial respiration and enhanced postactivation survival due to attenuated NO production in LPS-stimulated PWD DCs phenocopying human monocyte-derived DCs. To genetically map this phenotype, we used a congenic mouse strain (B6.PWD-Chr11.2) that carries a PWD-derived portion of chromosome 11, including Nos2, on a B6 background. B6.PWD-Chr11.2 DCs show preserved mitochondrial function and produce lower NO levels than B6 DCs. We demonstrate that activated B6.PWD-Chr11.2 DCs maintain mitochondrial respiration and TCA cycle carbon flux, compared with B6 DCs. However, reduced NO production by the PWD Nos2 allele results in impaired cellular control of Listeria monocytogenes replication. These studies establish a natural genetic model for restrained endogenous NO production to investigate the contribution of NO in regulating the interplay between DC metabolism and immune function. These findings suggest that reported differences between human and murine DCs may be an artifact of the limited genetic diversity of the mouse models used, underscoring the need for mouse genetic diversity in immunology research.
Two-Point versus Three-Point Fixation in the Management of Zygomaticomaxillary Complex Fractures
Authors: Gawande Mayur Janardan , Lambade Pravin N. , Bande Chandrashekhar , Gupta M. K. , Mahajan Monica , Dehankar Tejaswini 
Published: December 2021

Introduction:
The zygoma plays an important role in the facial contour for both cosmetic and functional reasons; therefore, zygomatic bone injuries should be properly diagnosed and adequately treated. Comparison of various surgical approaches and their complications can only be done objectively using outcome measurements that require a protocol for management and long-term follow-up. The objectives of this study were to compare the efficacy of zygomatic bone after treatment with open reduction internal fixation (ORIF) using two-point fixation and ORIF using three-point fixation and compare the outcome of two procedures.

Materials and Methods:
Twenty patients were randomly divided equally into two groups. In Group A, ten patients were treated by ORIF using two-point fixation by miniplates and in Group B, ten patients were treated by ORIF using three-point fixation by miniplates. They were evaluated with their advantages and disadvantages and the difference between the two groups was observed.

Results:
We found that postoperative facial and neurological complications are minimum in two-point fixation group. Based on this study, open reduction and internal fixation using two-point fixation by miniplates is sufficient and the best available treatment of choice for the management of zygomaticomaxillary complex fractures.

Discussion:
Alignment of the fracture at three points and fixation at two stable points provide the most accurate and satisfactory postoperative results. Two-point interosseous fixation at the “buttress” fracture and the frontozygomatic (FZ) fracture is suitable for routine surgery. The results of these studies confirm with the present study that two-point fixation provided better stability in patients with clinical and radiological evidence of fracture in FZ and zygomaticomaxillary buttress area.
Estimation of prevalence of bronchial asthma in preschool and prepubertal children using international study of asthma and allergies in childhood criteria in Raipur Chhattisgarh
Authors: Kale Renu , Khachhawaha Raghavendra S. 
Published: December 2021

OBJECTIVE:
Bronchial asthma is the most common chronic disease affecting children and young adults. The prevalence of asthma is on the rise worldwide with increasing levels of pollution. The epidemiology of asthma is a growing area of research. There is a paucity of data from central India, especially from Raipur, which has become the capital of Chattishgarh since the year 2000. This community-based study was conducted to estimate the prevalence of bronchial asthma in school going children aged between 6–7 years and 13–14 years.

MATERIALS AND METHODS:
A cross-sectional study using ISSAC questionnaires was conducted across 12 schools in Raipur, selected on a random basis. The required sample size of 1000/age group was needed according to International Study of Asthma and Allergies in Childhood criteria, so a total of 2029 children were recruited in both age groups. Data were managed in Microsoft Office Excel and were analyzed using tests of proportion.

RESULT:
Out of 2029 children evaluated, 153 (7.54%) had a positive history of wheezing throughout their lives and the relative number of wheezy girls was 7.56% as compared to boys 7.52%. Comparison between two age groups 6–7 and 13–14 years, wheezing incidence of 7.37% and 7.71% was similar with no significant difference. Confirmed asthma was detected in 2.32% of cases. No significant difference was noted in both age groups, i.e. 1.97% in 6–7 and 2.67% in 13–14 years. Higher incidence of exercise-induced wheeze was noted in older age group (13–14 years) children 5.04% versus 4.23%.

CONCLUSION:
The prevalence of bronchial asthma was 2.32% in children in Raipur. Increasing trends in prevalence due to increasing pollution needs environmental measure to control pollution.
Impact of long-term doxycycline on lung function & exacerbations
Authors: Bhattacharyya Parthasarathi , Singh Brajesh , Sarkar Surita , Das Soumen Kumar , Chakraborty Bodhisattwa , Saha Dipanjan , Chakraborty Kumar , Saha Indranil , Chaudhury Koel 
Published: December 2021

Background & objectives:
Upregulation of matrix metalloproteinases (MMPs) is related to the pathogenesis of chronic obstructive pulmonary disease (COPD). We aimed at assessing the tolerability and impact of long-term use of MMP inhibitor doxycycline in COPD.

Methods:
A cohort of COPD patients was randomized to continue a uniform COPD treatment with or without add-on long-term oral doxycycline. The lung exacerbations (spirometry), adverse events and health status (COPD Assessment Test score) were noted at 3, 6, 9 and 12 months of therapy. Measurement of the serum MMP-2, and 9 and high-sensitive C-reactive protein (hs-CRP) levels was done at the start of the study and at three months, whenever possible.

Results:
There were 27, 19, 13 and 10 patients with add-on doxycycline group and 22, 19, 11 and 7 patients with COPD treatment alone at 3, 6, 9 and 12 months of treatment respectively. The improvement was obviousaconsistent and serial improvement of health st nd mostly (at 6 and 12 months) significant (P>0.05) for lung function parameters [forced expiratory volume in one second (FEV1), FEV1/forced vital capacity (FVC) and forced expiratory flow at 25-75% of FVC (FEF25-75)] and universal for health status at all measurements, with an overall 26.69 per cent reduction in exacerbations. The analysis with the lung function changes in the available population with protocol violation also supported the same trend. The concomitant reduction in serum MMP-9 (P=0.01), MMP-2 (P=0.01) and hs-CRP (P=0.0001) levels (n=21) at three months was also significant. The adverse reactions with add-on doxycycline appeared acceptable.

Interpretation & conclusions:
Long-term doxycycline appears well tolerated and seems to improve lung function, health status and exacerbations in COPD. The claim needs further scientific validations.
Association of E-cadherin & vimentin expression with clinicopathological parameters in lingual squamous cell carcinomas & their role in incomplete epithelial mesenchymal transition
Authors: Goyal Neelakshi , Singh Meeta , Sagar Nishant , Khurana Nita , Singh Ishwar 
Published: December 2021

Background & objectives:
Lingual squamous cell carcinomas (SCC) pose a major public health burden in India. Epithelial-mesenchymal transition (EMT) is the conversion of an epithelial cell to a mesenchymal phenotype at the invasive front (IF) enhancing invasiveness of these cells which may be studied using immunohistochemistry. The objective of this study was to assess the expression of E-cadherin and vimentin at the IF, and their correlation with the histological risk assessment score, clinicopathological parameters and lymph node metastasis.

Methods:
Thirty consecutive untreated patients diagnosed as lingual SCC who underwent hemiglossectomy over one year formed the study group. The immunohistochemical expression of E-cadherin and vimentin in the periphery as well as the centre of tumour islands was correlated with clinicopathological parameters, Brandwein-Gensler risk assessment score and lymph node metastasis, along with a correlation between the coexpression of two markers at the IF.

Results:
Loss of E-cadherin expression was seen at IF in 83.3 per cent (25/30) cases. Out of these, 20 per cent (5/25) showed a corresponding gain in vimentin expression (complete epithelial-mesenchymal transition) and 80 per cent (20/25) did not. Overall, 16.6 per cent (5/30) cases showed complete EMT. However, no correlation between E- cadherin and vimentin expression at the IF was found. No statistical significance was found between E-cadherin loss and vimentin gain at the IF, with the various parameters or the risk score.

Interpretation & conclusions:
The present study suggests that the cells at IF may metastasize even without a gain in vimentin expression (without classical EMT), as cohesive clusters showing incomplete EMT (E-cadh-/Vim-).
Health system preparedness & community participation in Japanese encephalitis/acute encephalitis syndrome (JE/AES) prevention in a tribal district of Odisha, India
Authors: Sahoo Krushna Chandra , Negi Sapna , Dash Girish Chandra , Sahoo Rakesh Kumar , Kshatri Jaya Singh , Panda Sheetal , Pattanaik Matrujyoti , Badaik Goldi , Pati Sanghamitra , Bhattacharya Debdutta 
Published: December 2021

Background & Objectives:
Japanese encephalitis/acute encephalitis syndrome (JE/AES) is one of the major zoonotic arbodiseases that has a significant effect on human and animal health. Though many studies have been published on the epidemiology and transmission mechanisms of JE/AES, but there is little evidence on health system preparedness, including community-based engagement. This study was undertaken to explore a multi-stakeholder perspective on health system preparedness for the prevention of JE/AES in a tribal district of Odisha, India.

Methods:
This study was conducted at Malkangiri district of Odisha. A total of nine focus group discussions (FGDs) among women having under-five children, community volunteers, and community health workers (CHWs), and 20 in-depth-interviews (IDIs) among community leaders, healthcare providers, and programme managers were conducted. The FGDs and IDIs were digitally recorded, transcribed, translated and analysed using content analysis approach.

Results:
Health system preparedness for the prevention of JE/AES was improved, including effective vector management, implementation of the surveillance system, and vaccination programme. The JE vaccine was introduced under Universal Immunization Programme in Odisha in 2016. Behavioural Change Communication activities were provided with the support of community volunteers on Village Health Nutrition and Sanitation Day (VHNSD) under Gaon Kalyan Samiti (GKS) platforms. The CHWs were actively involved in vector management and raising sanitation and hygiene awareness.

Interpretation & conclusions:
Community participation and coordination between different stakeholders have a significant impact on the successful implementation of the programme. It was suggested that there was a need for a sustainability approach to active participation, orientation and capacity building training among CHWs and community volunteers to successfully implement the programme.
Tata Kelola Kolaboratif Ruang Terbuka Hijau: Sebuah Kajian Pustaka Terstruktur (Systematic Literature Review)
Authors: Pratama Irvan Dian , Salahudin  , Roziqin Ali 
Published: December 2021

Penelitian ini bertujuan untuk mengetahui tata kelola kolaboratif ruang terbuka hijau sudah berjalan dengan baik namun belum optimal dalam pengimplementasiannya. Penelitian ini menggunakan sistematis literatur review sebagai landasan dasar untuk mempermudah peneliti/mahasiswa agar dapat mengulas dan mengidentifikasi artikel ilmiah secara sistematis dengan langkah-langkah yang telah ditetapkan. Penelitian ini mengungkapkan terdapat 124 artikel yang telah diseleksi dari 378 artikel yang relevan dengan topik yang dibahas. Hasil analisis tersebut menghasilkan 3 cluster yang berbeda dalam 38 konsep yang relevan dengan studi tata kelola kolaboratif ruang terbuka hijau. Dalam penggunaan mode density visualization tidak adanya author yang mendominasi dalam mengkaji pemetaan data author sesuai tema tata kelola kolaboratif ruang terbuka hijau. Semuanya memiliki kedudukan yang sama pentingnya dalam melakukan temuan-temuan yang akan digunakan pada penelitian berikutnya. Penelitian ini mempunyai keterbatasan artikel untuk menunjang literatur review. Dari total keseluruhan artikel yang diperoleh melalui database scopus tidak semuanya memiliki keterkaitan topik yang akan di gunakan untuk melakukan penelitian, sehingga peneliti kesulitan dalam melakukan analisis. Rekomendasi peneliti terhadap penelitian selanjutnya perlunya penggunaan analisis dengan menambah beberapa artikel yang memiliki relevansi yang sama di beberapa sumber artikel ilmiah agar mempermudah dalam melakukan analisis data secara konkrit.
EBELİK ÖĞRENCİLERİNİN KİŞİLİK ÖZELLİKLERİ VE YAŞAM BOYU ÖĞRENME EĞİLİMLERİ ARASINDAKİ İLİŞKİ
Authors: BENLİ Tuğba Enise , İBİCİ AKÇA Emine , AKSOY DERYA Yeşim 
Published: December 2021

Amaç: Bu araştırma ebelik öğrencilerinin kişilik özellikleri ve yaşam boyu öğrenme eğilimleri arasındaki ilişkinin belirlenmesi amacıyla yapılmıştır.
Yöntem: Analitik-kesitsel tipte olan bu araştırma Türkiye’nin doğusunda bulunan bir üniversitenin Sağlık Bilimleri Fakültesi Ebelik Bölümü öğrencileri ile yürütülmüştür. Araştırmanın örneklemini 187 ebelik öğrencisi oluşturmuştur. Çalışmanın verileri “Kişisel Bilgi Formu”, “Beş Faktör Kişilik Özellikleri Ölçeği (BFKÖÖ)” ve “Yaşam Boyu Öğrenme Eğilimleri Ölçeği (YBÖEÖ)” ile toplanmıştır. Verilerin değerlendirmesinde SPSS (20.0) istatistik paket programında sayı, yüzde dağılımları, ortalama, standart sapma, independent t-test, One-Way Anova, Mann Whitney-U testi, Kruskal Wallis Testi, Tukey ve korelasyon testleri kullanılmıştır.
Bulgular: Öğrencilerin yaş ortalaması 20.99±2.41’dir. Öğrencilerin BFKÖÖ’nün “dışadönüklük”, “sorumluluk”, “açıklık”, “geçimlilik” ve “duygusal dengesizlik” alt boyutlarından aldıkları toplam puan ortalamaları sırasıyla; 26.62±6.59, 32.27±5.69, 36.09±6.73, 35.81±5.07 ve 24.86±5.06’dır. Öğrencilerin YBÖEÖ’den aldıkları toplam puan ortalamaları 126.81±19.55’tir. Öğrencilerin BFKÖÖ’ye ait dışadönüklük, sorumluluk, açıklık, geçimlilik alt boyutları ile yaşam boyu öğrenme eğilimleri arasında pozitif yönde; duygusal dengesizlik alt boyutu ile negatif yönde istatistiksel olarak anlamlı zayıf düzeyde bir korelasyon bulundu (p
Wakaf Polis Asuransi Jiwa Berdasarkan Wasiat Menurut Hukum Islam dan Undang-Undang Nomor 41 Tahun 2004 Tentang Wakaf
Authors: Saputra Agung Bagja , Lita Helza Nova , Nurhayati Elis 
Published: December 2021

Penelitian ini adalah untuk meneliti keabsahan wakaf wasiat polis asuransi serta pengaturan dan pengelolaannya menurut hukum Islam dan UU Wakaf. Polis asuransi dewasa ini dapat dijadikan objek wakaf, berdasarkan Fatwa DSN MUI Nomor 106/DSN-MUI/X/ 2016 tentang Wakaf Manfaat Asuransi dan Manfaat Investasi Pada Asuransi Jiwa Syariah, diatur pembatasan harta yang boleh diwakafkan adalah 45% sedangkan dalam UU Wakaf adalah 1/3 dari harta kekayaan atau Syirkah. Pasal 5 UU wakaf menyatakan bahwa fungsi wakaf adalah untuk mewujudkan potensi dan manfaat ekonomis harta benda wakaf untuk kepentingan ibadah dan memajukan kesejahteraan umum. Sehingga pengelolaan oleh lembaga wakaf harus di sesuaikan dengan syariat Islam yang berlaku karena peningkatan kesejahteraan umum harus selaras dengan kepentingan ibadah wakif yang menyerahkan harta nya untuk di kelola oleh lembaga wakaf. Melalui perolehan dana penggunaan objek wakaf wasiat dengan polis asuransi syariah adalah halal karena menggunakan akad tabbaru dan sistem sharing of risk sehingga terbebas dari unsur maisyir, riba dan gharar. Metodologi Penelitian yang digunakan melalui pendekatan Yuridis Normatif, tekhnik pengumpulan data melalui studi pustaka dengan menggunakan cara berpikir deduktif.
Kata Kunci : Wakaf Wasiat Polis Asuransi, Objek Wakaf, Wakaf
Role of Agnikarma in Gridhrasi (Sciatica) - A Conceptual Study
Authors: Swamy Bramhanand K , Vijayakumar Patil Akshata , Hiremat Sapna 
Published: December 2021

Pain is the chief cause of visiting a doctor in most patients. Vata is responsible for all painful conditions in the body. Gridhrasi is one among vataja nanatmaja vyadhi affecting the locomotor system in which pain is major symptom. The name itself indicates the way of gait shown by the patient due to extreme pain just like a Gridhrasi (Vulture).Â In Gridhrasi intense shooting pain start from sphik pradesha and radiates downwards to kati, prusta, uru, janu, jangha and pada in which the patient is unable to walk properly.Â The pain starts in the back and radiates down to one or both lower limbs.Â On the basis of symptoms of Gridhrasi; it can be equated with the disease sciatica in modern science. It occurs due to spinal nerve irritation and is characterized by pain in distribution of sciatic nerve. Statistically it is estimated that low back pain and radiating pain due to lumbar disc prolapse are major cause of morbidity throughout the world. The life time incidence of low back pain is 50-70% with incidence of sciatica more than 40%.Â It disturbs daily routine and overall life of the patient. In modern medical science, only symptomatic management with analgesics like NSAIDs and a very few surgical procedures are available.Â The surgical procedures are expensive with many limitations.Â In Ayurveda, various methods used in treatment of Gridhrasi are Bheshaja , Snehana, Swedana, Siravedha, Agnikarma and basti. Among these, Agnikarma is one of the para- surgical procedures which is very effective, simple, safe, cheap and having quick action. In current study a humble attempt is made to explain the role of Agnikarma in Gridhrasi.
Role of Ayurveda in the Management of Guillain-Barré Syndrome
Authors: Wajpeyi Sadhana Misar 
Published: December 2021

Guillain-Barré syndrome (GBS) is a peripheral neuropathy with acute onset, and characterized by rapidly developing motor weakness. It is autoimmune in nature and triggered by a preceding infection. A 48 years old female patient was brought with complaints of paralysis of all the four limbs (quadriplegia), back pain and pain in the right lower limb since one month. She was previously treated in tertiary care hospital with IV Immunoglobulin and plasmapheresis but showed no improvement. So she admitted and treated in Mahatma Gandhi Ayurved College Hospital & Research Centre, Salod (H) Wardha on 21.06.2018. In Ayurveda, there is no direct description of this disease but this condition can be correlated with Sarvanga vata (vata affecting all parts of the body), hence she was treated following principles of Vatavyadhi chikitsa which include Abhyanga (Oleation therapy), Swedana (Fomentation), Matrabasti (enema with medicated oil), Nasya (Nasal medicated oil administration) and various herbomineral formulations for 51 days. Along with this physiotherapy and Trans Electrical Nerve Stimulation was also applied. Significant results were observed in the form of improvement in the muscle power from zero to four for all the four limbs with improvement in her general condition as well as daily activities
Corrosion of Steels and Irons Immersed in Natural Seawater for up to 600 Y
Authors: Melchers Robert E. 
Published: December 2021

Marine immersion corrosion observations for archaeological and other data, including from shipwrecks, wrought iron anchors, and cast iron bridge piers are used to estimate corrosion losses in natural unpolluted coastal and near-coastal seawaters for exposures up to about 600 y. Empirical functions for the development of corrosion loss with time were then developed, standardized to 20°C mean seawater temperature. The resulting slightly nonlinear corrosion loss trend, represented by a modified form of the power law, is consistent with phase 4 of the previously proposed bi-modal corrosion model. These observations support the notion that the rate of long-term corrosion is controlled by outward diffusion, through the rust layers, of gaseous hydrogen generated by the cathodic hydrogen evolution reaction under predominantly anaerobic corrosion conditions. The power-law trend also provides good extrapolation from shorter-term data. For practical purposes for exposures &lt;100 y in seawaters with a mean temperature of around 20°C, a linear model, with a longer-term corrosion rate 0.06 mm/y at 20°C, is sufficiently accurate.