bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Nexus between Misallocation of Land Resources and Green Technological Innovation: A Novel Investigation of Chinese Cities
Authors: Gao Xincai , Wang Shuai , Ahmad Fayyaz , Chandio Abbas Ali , Ahmad Munir , Xue Dan 
Published: February 2021

Abstract
As an important production factor, land resources significantly impact green technology innovation (GTI). However, the misallocation of land resources caused by the government's "second-hand" land supply strategy has become increasingly prominent, which will adversely affect GTI by affecting the allocation of innovative elements. Based on the research data of 252 cities in China from 2008 to 2017, this paper uses panel space measurement estimation and panel threshold estimation empirical methods to test the theoretical hypothesis of the impact of misallocation of land resources on GTI. The study finds that local or neighboring land resources' misallocation has a hindering effect on local GTI. Furthermore, the misallocation of land resources has a threshold effect on the impact of GTI. The relatively high level of local economic development and environmental regulation reduces the restraining effect of the misallocation of land resources on GTI, and vice versa. Therefore, local governments should optimize the allocation of innovative elements, accelerate the construction of an efficient and market-oriented green technology innovation system, reduce the excessive intervention in land resources, and enhance the vitality of innovation entities to improve the level of green technology innovation.
Comparison of UAV RGB Imagery and Hyperspectral Remote-sensing Data for Monitoring Winter-wheat Growth
Authors: Feng Haikuan , Tao Huilin , Zhao Chunjiang , Li Zhenhai , Yang Guijun 
Published: February 2021

Abstract
Background: Although crop-growth monitoring is important for agricultural managers, it has always been a difficult research topic. However, unnamed aerial vehicles (UAVs) equipped with RGB and hyperspectral cameras can now acquire high-resolution remote-sensing images, which facilitates and accelerates such monitoring. Results: To explore the effect of monitoring a single crop-growth indicator and multiple indicators, this study combines six growth indicators (plant nitrogen content, above-ground biomass, plant water content, chlorophyll, leaf area index, and plant height) into a new comprehensive growth index (CGI). We investigate the performance of RGB imagery and hyperspectral data for monitoring crop growth based on multi-time estimation of the CGI. The CGI is estimated from the vegetation indices based on UAV hyperspectral data treated by linear, nonlinear, and multiple linear regression (MLR), partial least squares (PLSR), and random forest (RF). The results show that (1) the RGB-imagery indices red reflectance (r), the excess-red index(EXR), the vegetation atmospherically resistant index(VARI), and the modified green-red vegetation index(MGRVI) , as well as the spectral indices consisting of the linear combination index (LCI), the modified simple ratio index(MSR), the simple ratio vegetation index(SR), and the normalized difference vegetation index (NDVI)are more strongly correlated with the CGI than a single growth-monitoring indicator (2) The CGI estimation model is constructed by comparing a single RGB-imagery index and a spectral index, and the optimal RGB-imagery index corresponding to each of the four growth stage in order is r, r, r, EXR; the optimal spectral index is LCI for all four growth stages. (3) The MLR, PLSR, and RF methods are used to estimate the CGI. The MLR method produces the best estimates. (4) Finally, the CGI is more accurately estimated using the UAV hyperspectral indices than using the RGB-image indices.Conclusions: UAVs carrying RGB cameras and hyperspectral cameras have high inversion CGI accuracy and can judge the overall growth of wheat can provide a reference for monitoring the growth of wheat.
The caudal boundaries of the mesopancreatoduodenum based on the vascular anatomy associated with pancreaticoduodenectomy
Authors: Honjo Masahiko , Tohyama Taiji , Ogawa Kohei , Tamura Kei , Sakamoto Katsunori , Takai Akihiro , Watanabe Jota , Ohtani Hiromi , Takada Yasutsugu 
Published: February 2021

Abstract
Background The mesopancreas is important during pancreaticoduodenectomy (PD) in patients with periampullary and pancreatic head carcinoma. This study aimed to investigate whether the duodenojejunal uncinate process vein (DJUV) is a useful anatomical landmark for the caudal border of mesopancreatoduodenum resection.MethodsThis study enrolled 100 adult patients with hepatobiliary pancreatic disease who underwent preoperative multidetector-computed tomography (CT). The anatomy of the key blood vessels involved during PD was analyzed by preoperative CT. The DJUV was defined as the vein draining from the upper jejunum to the superior mesenteric vein adjacent to the uncinate process.ResultsAmong 89 cases, the first jejunal vein was the DJUV, whereas the second jejunal vein was the DJUV in 11 cases. The inferior pancreaticoduodenal artery and vein were located on the cranial side of the DJUV in all cases. The distance between the middle colonic artery and the DJUV was within 10 mm in 81% of cases, suggesting that resection of the mesopancreatoduodenum cranial to the DJUV provided sufficient dissection of regional lymph nodes around the superior mesenteric artery.ConclusionThe DJUV may be a useful anatomical landmark for the caudal border of the mesopancreatoduodenum resection during PD.
Postpartum Sexual Quality of Life: Scale Development and Psychometric Properties Assessment in Iran
Authors: Rahmani Azam , Grylka-Baeschlin Susanne , Fallahi Arezoo , Allahqoli Leila , Gheshlagh Reza Ghanei , Abboud Sarah , Rezaei Elham 
Published: February 2021

Abstract
Background: to develop and assess the psychometric properties of the Postpartum Sexual Quality of Life Scale (PSQLS) in Iran. Methods: We employed a mixed-method approach. In the qualitative phase (17 interviews and two focus groups), we generated items for the scale. In the quantitative phase (N=282), we assessed the psychometric properties of the pre-final version. Results: The final version contained 22 items. Exploratory factor analysis indicated a 5-factor solution that jointly accounted for 59.6% of the variance. Cronbach’s alpha coefficient was 0.87. Conclusion: The PSQLS showed good validity and reliability and could be used to evaluate women’s postpartum sexual life.
Seasonal hydrology influences energy channels in food webs of rivers in the lower Okavango Delta
Authors: Bokhutlo Thethela , Keppeler Friedrich W. , Winemiller Kirk O. 
Published: February 2021

Abstract
Describing species interactions and resource use can elucidate patterns of energy flow in ecosystems. Here, we analyzed stable isotope ratios (δ13C and δ15N) to infer seasonal variation in energy pathways and species foraging strategies in two rivers of the lower Okavango Delta, Botswana. We sampled fish during wet and dry seasons and estimated proportions of basal production sources assimilated by fish using Bayesian isotopic mixing models. We estimated modal trophic position for each fish population and assessed its correlation with the degree that biomass was supported by one production source. In the Boteti River during the wet season, biomass of most fishes was supported by food chains originating mainly from seston. During the dry season, C4 grasses assumed greater importance, and the degree of dependence on a single source was inversely related to trophic position. In the Boro River, seston was inferred to be an important production source supporting most species during both periods, and the degree of dependence on a single source was positively related to trophic position during the dry season, suggesting that species higher in the food web assimilated material disproportionately from one source during this period. Our findings support the idea that fish foraging habits shift in response to seasonal patterns of connectivity and habitat availability. We showed that consumers in river food webs are supported by multiple basal production sources and that seasonal hydrological pulsing, despite causing short-term changes in food web dynamics, may promote long-term population and community stability.
The Effect of Aflibercept and Arsenic Trioxide on the Proliferation, Migration and Apoptosis of Oral Squamous Cell Carcinoma in Vitro
Authors: Derakhshan Samira , Aminishakib Pouyan , Pirzadeh Fatemeh , Rahrotaban Sedigheh , Farzaneh Parvaneh , Shiraji Sahar Tavakoli , Ganjibakhsh Meysam , asadi masoumeh 
Published: February 2021

Abstract
Aflibercept and arsenic trioxide drugs apply a cytotoxic effect on some human cancer cell lines. However, no more study has followed the effects of both drugs, especially arsenic trioxide, on oral squamous cell carcinoma (OCC). We used three OCC lines as a model to show the effect of these drugs on the genetically complex disease and investigate its targeted therapy.In this study, three human OCC cell lines were used from different patients. We treated cell lines with both medications to detect the effect and relevant molecular basis. First, methyl thiazolyl tetrazolium (MTT) assay was performed to detect the cytotoxicity effect and cell growth. Second, western blot and flow cytometry were performed to evaluate the anti-angiogenic effect on OCC lines. Next apoptosis was analyzed by flow cytometry. Finally, clonogenesis capacity and cell migration were assessed by colony formation assay and wound healing, respectively.Aflibercept had no cytotoxic effect on the three OCC cell lines but decreased cell growth rate. Arsenic trioxide had a significant cytotoxic effect on three cell lines. Our results demonstrated that both drugs significantly decreased endoglin and VEGF expression. In addition, Migration and colony formation assays confirmed that these drugs have significant anti-proliferative and anti-migration effect on oral carcinoma cells.These results revealed that both medications might be a potential drug for the management of oral cancer patients.
Chinese Medicine PaBing-II Protects Human iPSC Derived Dopaminergic Neurons from Oxygen Stress
Authors: Wu Shouhai , Lin Tongxiang , Xu Yang 
Published: February 2021

Abstract
BackgroundPaBing-II Formula (PB-II) is a traditional Chinese medicine developed to treat Parkinson's disease (PD). However, due to the complexity of PB-II and the difficulty of culturing human dopaminergic neurons (DAn) in vitro, the mechanism of PB-II to treat PD remains unclear. MethodsWe established the human induced pluripotent stem cells (iPSCs) and derived DAn from hiPSCs to study the protective effects of PB-II on DAn after oxidative stress, which plays an important role in PD pathogenesis. ResultsWe found that serum derived from rats that had ingested PB-II significantly protect hiPSC-derived DAn from reactive oxygen species (ROS). In addition, PB-II dependent serum can activate nuclear erythroid-derived factor 2 (Nrf2) responses, which are required for the neutralization of ROS. In addition, PB-II can activate the Nrf2/ARE signal pathway of midbrain dopaminergic neurons of PD rats induced with 6-hydroxydopamine (6-OHDA) injury, rescue DAn cells, and improve the symptoms of PD rats. ConclusionsPB-II significantly protects the DA neurons from oxidative stress by activating the Nrf2 pathway.
Protein-Based Biostimulants Enhanced Early Growth And Establishment Of Sugar Beet
Authors: Jolayemi Okanlawon Lekan , Malik Ali Hafeez , Ekblad Tobias , Olsson Marie E. , Johansson Eva 
Published: February 2021

Abstract
PurposeThe effect of different concentrations, types and placements of protein-based biostimulants (PBs) on early growth and establishment of different varieties of sugar beet (Beta vulgaris L) was evaluated.MethodsThree PBs with varying concentrations (0 to 10 g/kg soil) and different placement methods in sandy-clayey soil were tested for their enhancement effect on growth and establishment of three sugar beet varieties.ResultsAll three PBs used in this study enhanced the growth of sugar beet by 59-127%, compared to control. A content of 1 or 2 g/kg soil showed significantly the highest effect on early plant growth, with an increase in plant height, plant canopy area and total biomass of sugar beet by >100%, >165% and 195% respectively compared to the control. Generally, the three sugar beet varieties responded similarly to PB treatments and there was no difference in the effect of placement of the PBs on early sugar beet growth. However, the combination of the PB “potato protein film (PF)” with varieties I and III, showed a significantly positive effect on plant height and plant canopy area for treatment up to 5 g/kg soil, compared to other PB-varieties combinations. A better enhancement effect was observed by the addition of PBs compared to nutrient solution, which implies that nutrients/amino acids was not the only reason for the positive effects of the PBs.ConclusionPBs, mixed with soil at low concentration, significantly enhanced early growth and establishment of sugar beet.
Development of an impedimetric sensor based on carbon dots and chitosan nanocomposite modified electrode for Cu (II) detection in Water
Authors: echabaane mosaab , Hfaiedh Salwa , Smiri Badreddine , Saidi Fawzi , Dridi Cherif 
Published: February 2021

Abstract
The fast and sensitive detection of copper ions would be essential for water monitoring. Herein, we report a novel development of impedimetric sensor based on carbon dots/chitosan nanocomposite. Carbon dots (CDs) were synthesized by simple heating of acidic aqueous solution of glucose. The CDs were characterized by TEM, FTIR, XRD, UV-visible, and PL. These measurements revealed that the CDs possess a mean size of 3.2 nm, graphitic structure with carboxyl and hydroxyl groups on the surface, and show particular optical properties. A glassy carbon electrode (GCE) was modiﬁed with a carbon dots/chitosan (CHITO) nanocomposite, and was characterized by transmission electron microscopy and electrochemical impedance spectroscopy (EIS). The CDs-CHITO/GCE electrode exhibits large surface area, good conductivity film, and charge transfer at interface film/electrolyte. The proposed impedimetric sensor exhibits a linear response to Cu(II) over 10-9 M to 10-5 M rang with a limit of detection at about 5×10-10 M. In addition, the sensor shows good selectivity toward Cu(II) ions, which is less than 5 %.Therefore, the as-developed impedimetric sensor exhibits good reproducibility, stability, selectivity, and a low limit of detection, which augur well for its application in water safety control processes.
Research on nonlinear vibration control of laminated cylindrical shells with discontinuous piezoelectric layer
Authors: Li Chaofeng , Li Peiyong , Miao Xueyang 
Published: February 2021

Abstract
In this paper, the nonlinear vibration control of the piezoelectric laminated cylindrical shell with point supported elastic boundary condition is analyzed, in which the geometric nonlinearity is considered by the first-order shear nonlinear shell theory. In the model, different boundary conditions are simulated by introducing a series of artificial springs. The elastic-electrically coupled differential equations of piezoelectric laminated cylindrical shells are obtained based on the Chebyshev polynomials and Lagrange equation, and decoupled by using the negative velocity feedback adjustment. Later, the Incremental Harmonic Balance Method (IHBM) is deduced, and the frequency-amplitude response of the piezoelectric laminated cylindrical shell is obtained by IHBM. Finally, the influence of the constant gain, size and position of the piezoelectric layer on frequency-amplitude response are investigated. The results show that the position, size and constant gain of the piezoelectric layer have a significant influence on its nonlinear vibration control.
Contraceptive use among sexually active female adolescents in Ethiopia: Trends and determinants from national demographic and health surveys
Authors: Olika Alemi Kebede , Kitila Sena Belina , Terfa Yonas Biratu , Olika Ayantu Kebede 
Published: February 2021

Abstract
Background: Sexual and reproductive health and right of adolescents is a global priority as the reproductive choices made by them have a massive impact on their health, wellbeing, education, and economy. Teenage pregnancy is a public health issue and a demographic challenge in Ethiopia. A contraceptive method is best for sexually active adolescents to prevent pregnancies and its related complications. However, little is known about the trends in contraceptive use and its determinants among adolescent girls in Ethiopia. Therefore, this study was designed to examine the trends and factors associated with contraceptive use among sexually active girls aged 15-19 years in Ethiopia by using Ethiopian demographic and health survey data. Methods: Four Ethiopian demographic and health survey data were used to examine trends of contraceptive methods use. To identify factors associated with contraceptive use, the 2016 Ethiopian demographic and health survey data were used. The data was downloaded from the demographic and health survey program database and extracted for sexually active adolescent girls. Data were weighted for analysis and analyzed using SPSS version 21. Descriptive analysis was used to describe the independent variables of the study. A multivariable logistic regression model was used to identify factors associated with contraceptive use and adjusted odds ratios with 95% confidence interval were presented for significant variables. Variables with a p-value less than 0.05 were considered as significantly associated with contraceptive use.Results: Contraceptive method use had increased significantly from 6.9% in 2000 to 39.6% in 2016 among sexually active adolescent girls in Ethiopia. The odds of contraceptive use were lower among female adolescents who had no formal education (AOR= 0.044; 95% CI= 0.008–0.231) and attended primary education (AOR= 0.101; 95% CI= 0.024–0.414). But the odds were higher among adolescents from a wealthy background (AOR= 3.662; 95% CI =1.353–9.913) and those who have visited health facilities and were informed about family planning (AOR= 3.115; 95% CI= 1.385–7.007).Conclusion: There is an increment in the trend of contraceptive use among sexually active female adolescents in Ethiopia between 2000 to 2016. Significant variations in the use of modern contraception by wealth status, educational level and visited a health facility, and being informed about family planning were observed. Improving the economic and educational status of young women, and provision of information may help in improving contraceptive use in Ethiopia.
Circulating long noncoding RNAs as potential biomarkers for stomach cancer: A systematic review and meta-analysis
Authors: Cao Fang , Hu Yongwei , Chen Zaichang , Han Wei , Lu Weijie , Xu Jianhao , Ding Houzhong , Shen Xiaojun 
Published: February 2021

Abstract
Background: Recent researches have suggested that long noncoding RNA (lncRNA) is involved in the tumorigenesis and development of stomach cancer (SC). This meta-analysis aimed to identify the diagnostic performance of circulating lncRNAs in SC.Methods: All relevant studies were systematically searched through PubMed, Web of Science, Cochrane Library and EMBASE databases. The diagnostic values of lncRNAs were mainly assessed by pooled sensitivity, specificity, and summary receiver operating characteristic area under the curve (SROC AUC). Meta-DiSc 1.4, Review Manager 5.3 and STATA 12.0 were used for statistical analysis. Results: A total of 42 eligible studies were included in this meta-analysis. The pooled sensitivity, specificity, and SROC AUC were 0.78 (95%CI: 0.75-0.81), 0.75 (95%CI: 0.71-0.78), and 0.83 (95%CI: 0.80-0.86) respectively, suggesting that the lncRNAs test had a high accuracy for the diagnosis of SC. Obvious heterogeneity might come from the type of lncRNA through subgroup and meta-regression analysis. Fagan diagram shows the clinical value of lncRNAs test in SC. Conclusions: Abnormal expression of circulating lncRNAs exhibits a high efficacy for diagnosing SC, which is promising in clinical application.
Influence of road salt thawing peaks on the inflow composition and activated sludge properties in municipal wastewater treatment
Authors: Tauber J. , Flesch B. , Parravicini V. , Svardal K. , Krampe J. 
Published: February 2021

Abstract
Operational data over 2 years from three large Austrian wastewater treatment plants (WWTPs) with design capacities of 4 million, 950,000 and 110,000 population equivalent (PE) were examined. Salt peaks, due to thawing road salt were detected and quantified by electrical conductivity, temperature and chloride measurement in the inflow of the WWTPs. Daily NaCl inflow loads up to 1,147 t/d and PE-specific loads of 0.26–0.5 kg NaCl/(PE · y) were found. To mimic the plants' behaviour in a controlled environment, NaCl was dosed into the inflow of a laboratory-scale activated sludge plant. The influence of salt peaks on important activated sludge parameters such as sludge volume index, settling velocity and floc size were investigated. Influent and effluent were sampled extensively to calculate removal rates. Respiration measurements were performed to quantify activated sludge activity. Particle size distributions of the activated sludge floc sizes were measured using laser diffraction particle sizing and showed a decrease of the floc size by approximately two-thirds. The floc structure was examined and documented using light microscopy. At salt concentrations below 1 g/L, increased respiration was found for autotrophic biomass, and between 1 and 3 g NaCl/L respiration was inhibited by up to 30%.
Absorption, Distribution, Metabolism, and Excretion of Aprocitentan, a Dual Endothelin Receptor Antagonist, in Humans
Authors: Sidharta Patricia N. , Fischer Hartmut , Dingemanse Jasper 
Published: February 2021

Background:
Aprocitentan is an orally active, dual endothelin receptor antagonist that may offer a
new therapeutic option for the treatment of difficult-to-control hypertension.

Objective:
To investigate safety, tolerability, mass balance, absorption, distribution, metabolism, and excretion
of aprocitentan.

Methods:
In this single-center, open-label study, a single oral dose of 25 mg containing 3.7 MBq of 14C-radiolabeled
aprocitentan was administered to 6 healthy male subjects. Metabolites were identified using mass spectrometry
and, where possible, confirmed and quantified with reference compounds.

Results:
Aprocitentan was well tolerated and there were no clinically significant findings for any safety variable.
The geometric mean cumulative recovery of radioactivity from urine and feces over 14 days was 77% of
the administered radioactive dose, with 52.1% cumulative recovery from urine and 24.8% from feces. Concentrations
of total radioactivity in whole blood were markedly lower compared to plasma. In plasma, 94.3% of total
radioactivity was aprocitentan. In urine and feces, 5 and 2, respectively (in feces one being aprocitentan)
main products were identified. Metabolism data of aprocitentan identified two main elimination pathways, glucosidation
to M3 and hydrolysis to M1, representing approximately 25% and 32% of the radioactive dose, respectively.

Conclusions:
Based on these metabolism data, aprocitentan can be concomitantly administered without dose adjustment
with drugs that are inhibitors or inducers of any metabolizing enzyme, specifically cytochrome P450
enzymes.