bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alexithymia, Suicidal Ideation and Behaviour in Moroccan Psychoactive Substance Users
Authors: Karjouh Khadija , Azzaoui Fatima-Zahra , Ouerchefani Riadh , semlali Wafae idrissi , Mammad Khaoula , Chtabou Ghizlane , Ahami Ahmed 
Published: January 2021

Abstract
Alexithymia is an emotion regulation problem that may be related to suicidality, especially in patients with SUD.The study aimed at estimating the prevalence of alexithymia in Moroccan psychoactive substances users, and to establish the links between alexithymia and suicidal ideation and behaviors, anxiety and depression in drug-dependent patients.We also aimed to elucidate if alexithymia predicts suicidal thoughts and behaviors in these consumers. The study included 451 consecutively admitted patients with substance use. Consumers were examined with the Toronto alexithymia scale (TAS-20), State and Trait Anxiety Inventory (STAI-Y), Beck Depression Inventory (BDI) and The Columbia-Suicide Severity Rating Scale (C-SSRS)Among substance-dependent individuals, 72.7% was identified as a group with alexithymia. Current age and age at first substance use were lower in the alexithymic group (p<0.01).The mean STAI-Y state and C-SSRS scores were higher in the group with alexithymia (p<0.01). There was a statistically significant difference between the groups in terms of mean scores for anxiety traits (p<0.05) and no significant difference in terms of mean scores for depression. All of the scores correlated significantly with.Addicted patients with alexithymia could be targeted at preventing the onset of suicidal thoughts and behaviorThe present study also evokes that whenever an emotional regulation disorder is observed, the possibility of anxio-depressive symptomatology and suicidality (ideation and behavior) needs to be assessed.
Anther Dehiscence Is Regulated By Gibberellic Acid In Yellow Lupine (Lupinus Luteus L.)
Authors: Marciniak Katarzyna , Przedniczek Krzysztof 
Published: January 2021

Abstract
Background:Anther dehiscence resulting in the release of pollen grains is tightly regulated in spatio-temporal manner by various factors. In yellow lupine (Lupinus luteus L.), the species which shows cleistogamy, the anthers split before the flowers open but the course and regulation of this process is unknown. Specific control of the anther development takes place with the participation of hormonal pathways, the wide action of which ensures reproductive success. In our previous research we have shown that the lowest transcript level of LlDELLA1, a main repressor of gibberellin (GA) signaling, in flower and early pod development occurs about the time of anther opening; therefore the main purpose of this study was to precisely investigate the gibberellic acid (GA3)-dependent regulation of anther dehiscence program in yellow lupine.Results:In this paper we showed the specific changes in the yellow lupine anther structure during the dehiscence and identified several genes widely-associated with this process, including deposition of lignocellulosic secondary thickening in the endothecium, enzymatic breakdown of cell walls at the septum/stomium and cell degeneration via programmed cell death (PCD). The expression profile of genes varied over time with the most intense mRNA accumulation in the phases prior to or about time of anther opening. The transcriptional activity revealed also that these genes are highly co-expressed and regulated in a GA-dependent manner. The cellular and tissue localization of GA3 exhibited that these molecules are present right before anther opening, mainly in septum cells, near the vascular bundle and in the endothecium, and later they were completely undetectable. The GA3 localization strongly correlates with the transcriptional activity of genes related with GA biosynthesis and deactivation. The obtained results also suggest that GA3 controls LlGAMYB expression via LlMIR159-dependent pathway.Conclusions:The presented results show a clear contribution of GA3 in the control of the extensive anther dehiscence program in yellow lupine. Understanding the processes underlying pollen release at hormonal and molecular level is a significant aspect in controlling fertility in economically important legume crop species and increased attention of breeders.
There is no special condition where a velocity of a light wave is invariance in all inertial frames.
Authors: Gupta Mahesh , Acharya Prafful , Yadav Rampravesh 
Published: January 2021

Abstract
This study of the literature reveals that the concept such as the velocity of a light wave is invariance in all inertial frames is wrong. A velocity of any motion always depends upon its reference frame. There is no special condition present in nature where the velocity is invariance in all inertial frames. Galileo Galilei defined speed is the distance covered per unit of time. Sir Isaac Newton defined velocity is the speed with direction. In the same period, physicists introduced the concept such as wavelength and frequency for measuring the speed a wave. The wave motion in which cycles are repeating after the same interval of time with the same distance between them. In 1887, Albert A. Michelson and Edward W. Morley performed an experiment to detect ether medium. But they failed to prove the existence of the ether medium and published Null Result. This Null Result has led to the creation of various new hypothetical theories. This study tries to reveal the relation between mathematics and physics and also comprehensive literature of light is a particle-wave duality in nature.
Potential of Preoperative Voiding Efficiency in Predicting Postoperative Α-1 Adrenergic Antagonist Usage After Transurethral Resection of the Prostate
Authors: Cheng Wei-Ming , Chiu Yi-Chun , Fan Yu-Hua , Hsu Che-Wei , Chang Chan-Chi , Weng Shih-Han , Chang Te-Wei 
Published: January 2021

Abstract
Background: Transurethral resection of the prostate (TURP) is the treatment of choice for patients with benign prostatic obstruction (BPO) who are refractory to medical treatment. Nevertheless, some patients still need α-1 adrenergic antagonists to control their post-TURP lower urinary tract symptoms (LUTS).Methods: In the present study, we developed a preoperative predictor of the continuous usage of α-1 adrenergic antagonists for post-TURP LUTS. We consecutively enrolled patients who underwent TURP at our hospital and divided them based on their use of α-1 adrenergic antagonists for more than 3 months postoperatively. Preoperative demographic data, including urodynamic parameters, were compared between the two groups. Forty-one patients were included in the study, with 17 patients (41%) receiving long-term α-1 adrenergic antagonists for their post-TURP LUTS.Results: Only lower pre-TURP voiding efficiency was significantly associated with long-term post-TURP α-1 adrenergic antagonist usage (63.3% vs. 75.1%, p = 0.03). A pre-TURP voiding efficiency of less than 75.48% had the greatest predictive ability, with a sensitivity of 88% and specificity of 50%.Conclusions: A preoperative voiding efficiency of less than 75.48% is a simple and noninvasive predictive factor for LUTS and would be helpful in preoperative evaluation and patient counseling.
Inflammatory Pseudo Tumor-Like Follicular Dendritic Cell Sarcoma of the Liver with Hepatic Lymphoma History: A Case Report and Literature Review
Authors: Li Jian , Wang Wenqiang , Chen Dong , Akilu Wajeehullahi , Huang Zhiyong , Zhang Erlei 
Published: January 2021

Abstract
Background: Inflammatory Pseudo Tumor (IPT)-like Follicular Dendritic Cell (FDC) Sarcoma of the liver is a very rare disease and occurs mostly in the lymph nodes. Till now, only 19 cases were reported in the English literature. However, the coexistence of IPT-like Sarcoma and Non-Hodgkin’s Lymphoma(NHL) in the same patient has never been reported.Case presentation: We reported a case of a 47-year-old male patient who had a history of Hepatitis B virus (HBV) infection and presented with right upper abdominal discomfort. Nineteen years ago, he underwent liver resection of segment VII for Hepatic Non-Hodgkin Lymphoma (B-cell lymphoma). Serum alpha fetoprotein (AFP) level was normal. However, Imaging studies revealed a well-circumscribed, solid mass in the right hepatic lobe and was diagnosed as (Hepatocellular Carcinoma) HCC or Hepatic Lymphoma preoperatively. Right hemi-hepatectomy was performed on this patient. Histological report showed features of a mixture of chronic inﬂammatory cells and variable amounts of spindle cells. Also, Immuno-Histo-Chemical (IHC) studies demonstrated that all the tumor cells showed strong nuclear in situ labeling for EBV-encoded small RNAs (EBER) and strongly positive stainings with CD21 and CD35. The patient is still disease free after a follow-up of 40 months. Conclusions: To our knowledge, this is the first report demonstrating Hepatic IPT-like FDC Sarcoma in a patient with Primary Hepatic Non-Hodgkin Lymphoma history. In regards to treatment, complete surgical resection should be performed and would acquire excellent long-term outcomes.
Quantitative Evaluation of Upright Posture by X-Ray and 3D Stereophotogrammetry With an Original Marker Placement Protocol in Late Onset Pompe Disease.
Authors: Blasiis Paolo De , Fullin Allegra , Sansone Mario , Viscovo Luca Del , Napolitano Filomena , Terracciano Chiara , Lus Giacomo , Melone Mariarosa Anna Beatrice , Sampaolo Simone 
Published: January 2021

Abstract
Background: Late Onset Pompe Disease (LOPD) is an autosomal recessive muscular disorder characterized by prevailing weakness of trunk and pelvic girdle muscles that causes ventilatory insufficiency and postural abnormalities. The most common myopathy phenotype described clinically in LOPD is the Limb Girdle and Diaphragmatic Pattern; spinal deformities, as hyperlordosis, hyperkyphosis and scoliosis diagnosed by x-Ray exam, have been reported in about a third of LOPD patients. The non-specific clinic onset, the similarity of the LOPD phenotypes with other myopathies, inter-individual heterogeneity and the lack of any disease hallmark, make early diagnosis challenging and, if enzyme replacement therapy does not begin timely, about 60% of patients develops severe motor and ventilatory disabilities.Aim of our study was to quantitatively assess the upright posture in a sibship of LOPD adults by x-Ray(xR) and 3D Stereophotogrammetry (St), considered the gold standard to measure spinal angles and whole-body posture respectively, in order to better identify specific alterations more likely to be present in a homogeneous group.Results: Statistical analysis of St parameters showed a larger ankle, knee, elbow, dorsal, S2-C7, heel-S2-C7, heel-S2-nasion angles and a lower sagittal vertical axis (SVA) than healthy controls. Moreover, xR analysis highlighted a lower occipito-cervical, C2-C7 cervical and Cobb dorsal angles, and a trend to lower lumbar lordosis and SVA compared to normal values. Pearson’s coefficient analysis was carried on in order to evaluate the correlation between xR and St sagittal spino-pelvic parameters and significant correlation was found in dorsal and lumbar angles calculated using xR markers placed on spiny apophysis, xR centre of vertebral bodies, Cobb method and St markers. Conclusions: This is the first study that quantitatively assesses standing whole-body alignment and postural abnormalities in LOPD. These postural alterations are not easily detectable during clinical examination and might be useful to early identify LOPD patients and to facilitate differential diagnosis with other proximal myopathies. Moreover, our St-mks placement protocol showed high reliability to assess any sagittal angles and, being non-invasive as compared to xR, is advisable to investigate and monitor the course of the disease and the response to treatment.
Association Between Plasma Glycocalyx Component Levels and Poor Prognosis in Influenza Type A (H1N1)
Authors: Huang Xiao , Lu Feng , Tian Huanhuuan , Hu Haoran , Ning Fangyu , Shang Quanmei , Hao Dong , Zhu Weiwei , Kong Guiqing , Ma Xiaohong , Feng Jiali , Wang Tao , Wang Xiaozhi 
Published: January 2021

Abstract
Background: Influenza A virus infection causes a series of diseases, but the factors associated with disease severity are not fully understood. Disruption of the endothelial glycocalyx contributes to acute lung injury in sepsis, but has not been well studied in H1N1 influenza. We aim to determine whether the plasma glycocalyx components levels are predictive of disease severity in H1N1 influenza.Methods: This prospective observational study included 53 patients with influenza A (H1N1), who were admitted to the Pulmonary and Critical Care Medicine and Intensive Care Unit, and 30 healthy controls between November 2017 and March 2019 in our hospital. Patients were grouped by severity and survival. We collected clinical data and blood samples at admission. Inflammatory factors (tumor necrosis factor-α, interleukin-6, interleukin-10) and endothelial glycocalyx components (syndecan-1, hyaluronan, heparan sulfate) were measured.Results: The plasma levels of syndecan-1, hyaluronan, and heparan sulfate were significantly higher in patients with severe influenza A (H1N1) than in mild cases. At a cutoff point >81.0 ng/mL, syndecan-1 had a 92.1% sensitivity and 86.7% specificity for diagnosing severe H1N1. Syndecan-1 and hyaluronan were positively correlated with disease severity, which was indicated by the APACHE II and SOFA scores and lactate levels, and negatively correlated with albumin levels. Non-survivors had higher syndecan-1 levels than did survivors, and syndecan-1 was strongly predictive of 28-day mortality (area under the curve, 0.855).Conclusions: An increased plasma syndecan-1 level was an independent risk factor for mortality and may be indicative of disease severity in patients with influenza A (H1N1).Trial registration: CHINA, ChiCTR2000040921. Retrospectively registered
Cutaneous Iontophoresis of Vasoactive Medications in Patients with Scleroderma- Associated Pulmonary Arterial Hypertension
Authors: Ampnti Sami Al , Almoushref Allaa , Naal Tawfeq , Melillo Celia , Aulak Kulwant S. , Ahmed Mostafa K. , Chatterjee Soumya , Highland Kristin , Dweik Raed A. , Tonelli Adriano 
Published: January 2021

Abstract
Background:It remains unknown whether the cutaneous microvascular responses are different between patients with scleroderma-associated pulmonary arterial hypertension (SSc-PAH) and SSc without pulmonary hypertension (PH).Methods:We included 59 patients with SSc between March 2013 and September 2019. We divided patients into 4 groups: a) no PH by right heart catheterization (RHC) (n=8), b) no PH by noninvasive screening tests (n=16), c) treatment naïve PAH (n=16) and d) PAH under treatment (n=19). Microvascular studies using laser Doppler flowmetry (LDF) were done immediately after RHC or at the time of an outpatient clinic visit (group b). Results:The median (IQR) age was 59 (54-68) years, and 90% were females. The responses to thermal and post occlusive reactive hyperemia, acetylcholine, and sodium nitroprusside iontophoresis were similar among groups. The microvascular response to treprostinil was more pronounced in SSc patients without PH by screening tests (% change: 340 (214-781)) compared with SSc-PAH (naïve + treatment) (Perfusion Units (PU) % change: 153 (94-255) % [p=0.01]). The response to A-350619 (a sGC activator) was significantly higher in patients with SSc without PH by screening tests (PU % change: 168 (46-1,296)) than those with SSc-PAH (PU % change: 22 (15-57) % [p=0.006]). The % change in PU with A350619 was directly associated with cardiac index and stroke volume index (R: 0.36, p=0.03 and 0.39, p=0.02, respectively). Conclusions:Patients with SSc-PAH have a lower cutaneous microvascular response to a prostacyclin analog treprostinil and the sGC activator A-350619 when compared with patients with SSc and no evidence of PH on screening tests.
Cytoplasmic String Between ICM&nbsp;and mTE&nbsp;Is a Positive Predictor of Clinical Pregnancy and Live Birth Outcomes in Elective Frozen-thawed Single Blastocyst Transfer Cycles: A Time-lapse Study
Authors: Ma Bingxin , Jin Lei , Huang Bo 
Published: January 2021

Abstract
Background: In this study, we aim to investigate whether cytoplasmic string between inner cell mass (ICM) and mural trophectoderm (mTE) is a positive predictor of clinical pregnancy and live birth outcomes.Methods: 1,267 elective frozen-thawed single blastocyst transfer (eSBT) cycles cultured in time-lapse incubation system from January 2018 to May 2019 were involved in the study. Blastocysts were grouped according to the appearance of cytoplasmic strings between ICM and mTE cells, and identified as “Present” and “Absent” groups. In Present group, they were further categorized according to the quantity of cytoplasmic strings between ICM and mTE cells. Clinical pregnancy and live birth outcomes of blastocysts were used to evaluate the effect of cytoplasmic strings between ICM and mTE.Results: The baseline demographic and laboratory features were similar between the Present and Absent groups of cytoplasmic strings between ICM and mTE (P>0.05). According to the time-lapse analysis, cytoplasmic strings between ICM and mTE were more visible among good quality blastocysts. Furthermore, blastocysts with cytoplasmic strings showed a higher clinical pregnancy and live birth rates (P<0.05), and no significant differences were observed in abortion rate and birth weight (P>0.05).Conclusions: Although the previous conclusions of cytoplasmic strings were controversial, the present time-lapse analysis provides the evidence for the first time that cytoplasmic strings between ICM and mTE cells would be a positive predictor of clinical pregnancy and live birth outcomes in elective frozen-thawed single blastocyst transfer cycles.
The Skill Training of Resident Anesthesiologists During the Outbreak Of COVID-19
Authors: Xie Min , Zhou Qin , Kang Yuanyuan , Qing Ping , Guo Yang , Wei Xinchuan , Cai Bing , Zeng Jie , Huang Jianxin 
Published: January 2021

Abstract
Background: With the spread of the coronavirus disease 19 (COVID-19), Sichuan provincial people's hospital, at the frontline fighting this public health crisis, took a lead in the reception, diagnosis and treatment of patients with COVID – 19 in the greater Sichuan area. As an effort to prevent nosocomial infections among the medical staff, we switched from the traditional face-to-face instruction to a web-based multimodal teaching model in our resident training program. Specifically, we explored ways to provide remote training in the proper procedure of donning and doffing of personal protective equipment (PPE). The purpose of the study was to evaluate the effectiveness of various teaching methods in teaching clinical skills of our residents during the epidemic period.Methods: 72 resident anesthesiologists (1st to 3rd year) were recruited to receive remote skill training on donning and doffing of PPE. In this study, all participants received instructional videos/text for the proper protocol, in addition to watching a live-stream instructional video that simulated the procedure of donning and doffing of PPE. We matched the residents by year and divided them into two groups through a WeChat Draw Program. The video feedback (VF) group recorded and submitted videos of simulated donning and removing PPE followed by a debriefing session through a collaborative WeChat learning group. The independent learning (IL) group did not record videos, but were encouraged to consult with their instructors by WeChat or phone if they had any questions. Then the two groups completed questionnaire as well as theory tests and skill assessment. Results: The VF group responded positively to the additional video-recording/debriefing approach. We did not observe any significant difference between the two groups in theoretical test scores. However, the VF group had significantly higher performance than the IL group in skill assessment. Conclusion: The web-based teaching, simulation teaching and video feedback model is an effective alternative to the conventional face-to-face instruction as part of an adapted resident training curriculum involving donning and doffing of protective equipment during an epidemic outbreak.
Nurses’ Encountered Challenges with Patient-centered Care in&nbsp;Rural Primary Health Care Centers: A Case Study of Nigeria
Authors: Lateef Adepeju , Mhlongo Euphemia Mbali 
Published: January 2021

Abstract
BackgroundGlobally, patient-centered care has become the focus of the healthcare system. Therefore, it is imperative to note that patient-centered care seeks to empower partnering approaches to primary health care and has recently gained prominence in nursing practice and applied nursing research. However, nurses are faced with numerous challenges in achieving the desired results and objectives related to Patient-centered care in the Primary Health Care system. Thus, the study explores the negative factors influencing the implementation of Patient-centered care in rural Primary Health Care facilities in Nigeria.MethodA qualitative participatory action research design was used. Data collection was conducted with the nurses from Primary Health Care facilities through individual interviews and focus group discussions. Data saturation was achieved with 35 participants from 30 Primary Health Care facilities in Osun State, Southwest Nigeria, using a purposive sampling technique. All interviews were audio-recorded, which were later transcribed verbatim and analyzed using a thematic content analysis approach. NVivo 12 software was used for data management.ResultsThe results from this study was categorized into two: organizational factors and individual factors. Five themes that emerged from the study include: inadequate management support, insufficient operational skills and knowledge /equipped learning, increased workload and time constraints, health personnel readiness, dearth enthusiasm for change and accountability of the staff.ConclusionThe results of this study show that nurses encountered diverse challenges in the implementation of patient-centered care. To improve healthcare delivery quality in the Primary Health Care facilities, there is a need to reinforce adequate management support, education, training, and the nurses’ internal motivation to achieve a transformative healthcare outcome.
A Precision Medicine Framework for Personalized Simulation of Hemodynamics in Cerebrovascular Disease
Authors: Frey Dietmar , Livne Michelle , Leppin Heiko , Akay Ela Marie , Aydin Orhun , Behland Jonas , Sobesky Jan , Vajkoczy Peter , Madai Vince Istvan 
Published: January 2021

Abstract
Cerebrovascular disease, in particular stroke, is a major public health challenge. An important biomarker is cerebral hemodynamics. To measure and quantify cerebral hemodynamics, however, only invasive, potentially harmful or time-to-treatment prolonging methods are available. We present a simulation-based approach which allows calculation of cerebral hemodynamics based on the patient-individual vessel configuration derived from structural vessel imaging. For this, we implemented a framework allowing segmentation and annotation of brain vessels from structural imaging followed by 0-dimensional lumped simulation modelling of cerebral hemodynamics. For annotation, a 3D-graphical user interface was implemented. For 0D-simulation, we used a modified nodal analysis, which was adapted for easy implementation by code. The simulation enables identification of areas vulnerable to stroke and simulation of changes due to different systemic blood pressures. Moreover, sensitivity analysis was implemented allowing the live simulation of changes to simulate procedures and disease progression. Beyond presentation of the framework, we demonstrated in an exploratory analysis in 67 patients that the simulation has a high specificity and low to moderate sensitivity to detect perfusion changes in classic perfusion imaging. The presented precision medicine approach using novel biomarkers has the potential to make the application of harmful and complex perfusion methods obsolete.