bluuebunny/crossref_metadata_2025_split huggingface dataset:
Too close for comfort? The impact of salesperson‐customer proximity on consumers' purchase behavior
Authors: Otterbring Tobias , Wu Freeman , Kristensson Per 
Published: June 2021

AbstractAcross a series of lab and field studies, with a total sample of over 1200 participants, we investigate how the physical proximity between salespeople and customers can impact store loyalty, purchase intentions, and actual spending. An initial survey among a representative sample of retail salespeople reveals that they associate close physical proximity between employees and customers with positive consumer outcomes, an intuition that dovetails with prior research documenting the positive influence of such proximity on purchase intentions, particularly in nonexpressive consumption contexts. Contrary to this work, we demonstrate, across four studies in which proximity was both measured and manipulated, that store loyalty, purchase intentions, and actual spending behavior are negatively impacted when consumers encounter a salesperson who is standing close by (vs. farther away), particularly in expressive consumption contexts. Psychological discomfort mediates this effect, such that consumers experience greater discomfort when a salesperson is standing close by, which in turn decreases spending. Importantly, this phenomenon is moderated by identity relevance, such that the negative influence of salesperson‐customer proximity specifically emerges when consumers think about products in terms of their ability to express their identities. These findings carry important implications for retailers operating in expressive consumption contexts.
Magnetic Resonance‐Guided Focused Ultrasound Thalamotomy for Focal Hand Dystonia: A Pilot Study
Authors: Horisawa Shiro , Yamaguchi Toshio , Abe Keiichi , Hori Hiroki , Fukui Atsushi , Iijima Mutsumi , Sumi Masatake , Hodotsuka Kenichi , Konishi Yoshiyuki , Kawamata Takakazu , Taira Takaomi 
Published: June 2021

ABSTRACTBackgroundThe efficacy of magnetic resonance‐guided focused ultrasound (MRgFUS) thalamotomy for the treatment of focal hand dystonia (FHD) is not well known.ObjectiveWe aimed to prospectively investigate the efficacy of MRgFUS thalamotomy for the treatment of FHD.MethodsWe performed MRgFUS thalamotomy of the ventro‐oral (Vo) nucleus in 10 patients with FHD. We evaluated the scores of the Writer's Cramp Rating Scale (WCRS, 0–30; higher scores indicating greater severity), Tubiana Musician's Dystonia Scale (TMDS, 0–5; lower scores indicating greater severity), and Arm Dystonia Disability Scale (ADDS, 0%–100%; lower scores indicating greater disability) at baseline and 3 and 12 months post‐treatment.ResultsWCRS, TMDS, and ADDS scores significantly improved from 6.3 ± 2.7, 1.4 ± 0.5, and 58.7% ± 14.3% at baseline to 1.6 ± 3.1 (P = 0.011), 5.0 ± 0 (P = 0.0001), and 81.6% ± 22.9% (P = 0.0229) at 12 months, respectively. There was one prolonged case of dysarthria at 12 months.ConclusionWe show that MRgFUS Vo‐thalamotomy significantly improved FHD. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
All‐pass phaser on a base of half‐wave coupled‐line section and its application
Authors: Gorbachev Anatoly , Parshin Yuriy 
Published: June 2021

AbstractThe principles and design method of modified all‐pass phase shifter (phaser) are presented. As a key component of Butler matrix (BM), the proposed phaser offers the possibility to realize BM with additional degree of freedom. The design procedure of the four‐beam dipole phased array with the proposed phasers is discussed and illustrated. As experimental verification, the four‐beam array for 2.2 GHz applications is manufactured and tested. Satisfying performances at matching, co– and cross–polarization patterns among all input ports can be observed covering a 12% relative bandwidth.
Facile synthesis of copper oxide nanoparticles‐decorated polyaniline nanofibers with enhanced electrochemical performance as supercapacitor electrode
Authors: Ahmad Md. Wasi , Anand Surbhi , Fatima Atiya , Yang Duck‐Joo , Choudhury Arup 
Published: June 2021

AbstractCopper oxide‐decorated polyaniline nanofibers (CuO@PANiNFs) nanocomposite was prepared through in situ chemical deposition of CuO nanoparticles on the PANiNFs. The results of spectroscopic analyses suggested the presence of strong interfacial interactions between CuO nanoparticles and PANiNF matrix, while X‐ray diffraction (XRD) analysis confirmed the formation of CuO monoclinic crystal phase on PANiNFs. SEM images displayed a uniform dispersion of CuO nanoparticles on the surface of PANiNFs. The highest specific capacitance of 486.9 F/g and area specific capacitance of 169 F/cm2 at 0.5 mA/cm2 were achieved for the CuO@PANiNFs nanocomposite. This could be ascribed to the low solution resistance and charge‐transfer resistance of nanocomposite electrode as observed in the electrical impedance spectroscopic results. The CuO@PANiNFs electrode revealed good cyclic stability with ~82% capacitance retention after 2000 cycles. The CuO@PANiNFs electrode delivered a maximum energy density of 67.7 Wh/kg, which is nearly 1.8 times higher than that of the pure PANiNFs electrode. Therefore, the present CuO@PANiNFs nanocomposite with high specific capacitance and energy density could be used as a cost‐effective, ecofriendly, and sustainable supercapacitor electrode material.
Impact of acute kidney injury on overall survival in children and young adults undergoing allogeneic hematopoietic stem cell transplantation
Authors: Matsuoka Daisuke , Hirabayashi Koichi , Murase Tsubasa , Saito Shoji , Nakazawa Yozo 
Published: June 2021

AbstractBackgroundAcute kidney injury (AKI) is a complication after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Increasing severity of AKI is associated with an increased risk of death. However, the impact of AKI in patients with malignant versus nonmalignant disease has not been reported. We investigated the incidence of AKI within the first 100 days after allo‐HSCT and the impact of AKI on both 3‐year overall survival (OS) and cumulative incidence of death after allo‐HSCT in all patients and in patients with/without malignant primary diseases.MethodsWe performed a retrospective analysis of 107 consecutive pediatric and young adult patients who received their first allo‐HSCT. AKI was classified into three grades according to the Acute Kidney Injury Network classification system.ResultsThe cumulative incidences of AKI stages 1–3, 2–3, and 3, at day 100 after allo‐HSCT were 34.6% (95% confidence interval [CI], 25.7%–43.6%), 17.8% (95% CI, 11.2%–25.6%), and 3.7% (95% CI, 1.2%–8.6%), respectively. OS was reduced for patients with AKI compared with patients without AKI (60.4% vs. 79.6%, p = .038). The cumulative incidence of death in the AKI group with nonmalignant disease was significantly higher than that in the no‐AKI group (44.4% vs. 0%, p = .003).ConclusionAKI after allo‐HSCT was not only a frequent event but also related to reduced OS. We recommend that all patients receiving allo‐HSCT, especially patients with nonmalignant diseases, be closely monitored for AKI.
Towards markerless computer assisted surgery: Application to total knee arthroplasty
Authors: Sta Salaheddine , Ogor Jérôme , Letissier Hoel , Stindel Eric , Hamitouche Chafiaa , Dardenne Guillaume 
Published: June 2021

AbstractPurposeA new approach is proposed to localise surgical instruments for Computer Assisted Orthopaedic Surgery (CAOS) that aims at overpassing the limitations of conventional CAOS solutions. This approach relies on both a depth sensor and a 6D pose estimation algorithm.MethodsThe Point‐Pair Features (PPF) algorithm was used to estimate the pose of a Patient‐Specific Instrument (PSI) for Total Knee Arthroplasty (TKA). Four depth sensors have been compared. Three scores have been computed to assess the performances: The Depth Fitting Error (DFE), the Pose Errors, and the Success Rate.ResultsThe obtained results demonstrate higher performances for the Microsoft Kinect Azure in terms of DFE. The Occipital Structure core shows better behavior in terms of Pose Errors and Success Rate.ConclusionThis comparative study presents the first depth‐sensor based solution allowing the intraoperative markerless localization of surgical instruments in orthopedics.
Iterative learning control for multi‐agent systems with noninstantaneous impulsive consensus tracking
Authors: Qiu Wanzheng , Wang JinRong 
Published: June 2021

AbstractIn this paper, we consider the consistent tracking problem of noninstantaneous impulsive multi‐agent systems. Take advantage of the repeatability of tracking tasks and the learning ability of each agent, we show that all agents of linear systems are driven to achieve a given asymptotical consensus as the number of iteration increases by using the standard ‐type learning law with the initial state learning rule. In addition, for nonlinear systems, we use ‐type learning law with the initial state learning rule to prove that all agents are driven to achieve a given asymptotical consensus as the number of iteration increases. Finally, two numerical examples are given to verify the effectiveness of our algorithm.
Type 2 Diabetes Mellitus Duration and Obesity alter the Efficacy of Autologously Transplanted Bone Marrow-derived Mesenchymal Stem/Stromal Cells
Authors: Nguyen Liem Thanh , Hoang Duc M. , Nguyen Kien T. , Bui Duc M. , Nguyen Hieu T. , Le Hong T.A. , Hoang Van T. , Bui Hue T. H. , Dam Phuong T.M. , Hoang Xuan T.A. , Ngo Anh T.L. , Le Hang M. , Phung Nhi Y. , Vu Duc M. , Duong Trung T. , Nguyen Tu D. , Ha Lien T. , Bui Hoa T.P. , Nguyen Hoa K. , Heke Michael , Bui Anh V. 
Published: June 2021

Abstract
Human bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) represent promising stem cell therapy for the treatment of type 2 diabetes mellitus (T2DM), but the results of autologous BM-MSC administration in T2DM patients are contradictory. The purpose of this study was to test the hypothesis that autologous BM-MSC administration in T2DM patient is safe and that the efficacy of the treatment is dependant on the quality of the autologous BM-MSC population and administration routes. T2DM patients were enrolled, randomly assigned (1:1) by a computer-based system into the intravenous and dorsal pancreatic arterial groups. The safety was assessed in all the treated patients, and the efficacy was evaluated based on the absolute changes in the hemoglobin A1c, fasting blood glucose, and C-peptide levels throughout the 12-month follow-up. Our data indicated that autologous BM-MSC administration was well tolerated in 30 T2DM patients. Short-term therapeutic effects were observed in patients with T2DM duration of &lt;10 years and a body mass index &lt;23, which is in line with the phenotypic analysis of the autologous BM-MSC population. T2DM duration directly altered the proliferation rate of BM-MSCs, abrogated the glycolysis and mitochondria respiration of BM-MSCs, and induced the accumulation of mitochondria DNA mutation. Our data suggest that autologous administration of BM-MSCs in the treatment of T2DM should be performed in patients with T2DM duration &lt;10 years and no obesity. Prior to further confirming the effects of T2DM on BM-MSC biology, future work with a larger cohort focusing on patients with different T2DM history is needed to understand the mechanism underlying our observation.
Health Utilities for Non-Melanoma Skin Cancers and Pre-Cancerous Lesions: A Systematic Review
Authors: So C. , Cust A. E. , Gordon L. G. , Morton R. L. , Canfell K. , Ngo P. , Dieng M. , McLoughlin K. , Watts C. 
Published: June 2021

Abstract

Background
Non-melanoma skin cancers (NMSCs) are common and consume many healthcare resources. A health utility is a single preference-based value for assessing health-related quality of life, which can be used in economic evaluations. There are scarce data on health utilities for NMSCs.

Objectives
Using a systematic review approach, we synthesized the current data on NMSC-related health utilities.

Methods
A systematic review of studies of NMSC-related health utilities was conducted in Medline, Embase, and Cochrane databases. Data were extracted based on the protocol and a quality assessment was performed for each study.

Results
The protocol resulted in 16 studies, involving 121 621 participants. Mean utility values across the studies ranged from 0.56 to 1 for undifferentiated NMSC, 0.84 to 1 for actinic keratosis, 0.45 to 1 for squamous cell carcinoma, and 0.67 to 1 for basal cell carcinoma. There was considerable variability in utilities by type of cancer, stage of diagnosis, time to treatment, treatment modality, and quality of life instrument or method. Utility values were predominantly based on the EuroQol 5-dimension instrument and ranged from 0.45 to 0.96, while other measurement methods produced values ranging from 0.67 to 1. Lower utility values were observed for advanced cancers and for the time period during and immediately after treatment, after which values gradually returned to pre-treatment levels.

Conclusions
Most utility values clustered around relatively high values of 0.8 to 1, suggesting small decrements in quality of life associated with most NMSCs and their precursors. Variability in utilities indicates that careful characterization is required for measures to be used in economic evaluations.
miR‐486‐3p regulates CyclinD1 and promotes fluoride‐induced osteoblast proliferation and activation
Authors: Ouyang Ting , Qin Yu , Luo Keke , Han Xue , Yu Chun , Zhang Aihua , Pan Xueli 
Published: June 2021

AbstractFluoride is a persistent environmental pollutant, and its excessive intake contributes to skeletal and dental fluorosis. The mechanisms underlying fluoride‐induced abnormal osteoblast proliferation and activation, which are related to skeletal fluorosis, have not yet been fully clarified. As important epigenetic regulators, microRNAs (miRNAs) participate in bone metabolism. On the basis of our previous miRNA‐seq results and bioinformatics analysis, this study investigated the role and specific molecular mechanism of miR‐486‐3p in fluoride‐induced osteoblast proliferation and activation via CyclinD1. Herein, in the fluoride‐challenged population, we observed that miR‐486‐3p expression decreased while CyclinD1 and transforming growth factor (TGF)‐β1 increased, and miR‐486‐3p level correlated negatively with the expression of CyclinD1 and TGF‐β1 genes. Further, we verified that sodium fluoride (NaF) decreases miR‐486‐3p expression in human osteoblasts and overexpression of miR‐486‐3p reduces fluoride‐induced osteoblast proliferation and activation. Meanwhile, we demonstrated that miR‐486‐3p regulates NaF‐induced upregulation of CyclinD1 by directly targeting its 3′‐untranslated region (3′‐UTR). In addition, we observed that NaF activates the TGF‐β1/Smad2/3/CyclinD1 axis and miR‐486‐3p mediates transcriptional regulation of CyclinD1 by TGF‐β1/Smad2/3 signaling pathway via targeting TGF‐β1 3′‐UTR in vitro. This study, thus, contributes significantly in revealing the mechanism of miR‐486‐3p‐mediated CyclinD1 upregulation in skeletal fluorosis and sheds new light on endemic fluorosis treatment.
Woven EndoBridge (WEB) Width at the Aneurysm Neck Level Affects Early Angiographic Aneurysm Occlusion
Authors: Nawka Marie Teresa , Broocks Gabriel , McDonough Rosalie , Fiehler Jens , Bester Maxim 
Published: June 2021

Abstract
Purpose
Endovascular therapy with the Woven EndoBridge (WEB) device is a safe treatment approach, whereby neoendothelialization at the neck area is a crucial element for aneurysm occlusion. We hypothesized that WEB sizing at the aneurysmal neck level has an impact on early aneurysm occlusion.

Methods
Patients with short-term follow-up digital subtraction angiography following WEB treatment of unruptured aneurysms were included. Aneurysms were categorized according to the Bicêtre Occlusion Scale Score (BOSS) as adequately (BOSS 0, 0′, 1) or partially occluded (BOSS 2, 3, 1 + 3). The WEB device dimensions, including the average aneurysm diameter (AADi) and the average neck diameter (ANDi) as well as baseline patient characteristics were documented.

Results
In this study 75 patients with 76 aneurysms were included and 65 aneurysms showed adequate occlusion at short-term follow-up (86%). In univariable logistic regression analysis, smaller differences in WEB size to ANDi (D-ANDi) were significantly associated with adequate aneurysm occlusion (odds ratio, OR = 0.41, 95% confidence interval, CI 0.23–0.71, p = 0.002). Receiver operating characteristic (ROC) curve analyses displayed higher discriminative power for the D‑ANDi (AUC = 0.77, 95% CI 0.66–0.86, cut-off ≤2.9 mm) compared to the difference in WEB size to the average aneurysm diameter (D-AADi, AUC = 0.65, 95% CI 0.53–0.75, cut-off ≤1.0 mm).

Conclusion
Smaller differences between the WEB width and ANDi were associated with adequate early aneurysm occlusion and might thus have a higher impact on the results than the traditional device sizing considering the mean aneurysm diameter. D‑ANDi ≤2.9 mm served as an optimal cut-off to classify occlusion after WEB treatment at the short-term follow-up. Further external validation is warranted.
Observational study investigating Ectoin® Rhinitis Nasal Spray as natural treatment option of acute rhinosinusitis compared to treatment with Xylometazoline
Authors: Werkhäuser Nina , Bilstein Andreas , Mahlstedt Kathrin , Sonnemann Uwe 
Published: June 2021

Abstract
Introduction
Symptomatic relief of acute rhinosinusitis is commonly achieved with nasal decongestants. The current observational study investigated the efficacy and safety of treatment of acute rhinosinusitis with Ectoin® Rhinitis Spray compared to or in combination with Xylometazoline-containing decongesting nasal spray.

Methods
Patients with acute rhinosinusitis applied either Ectoin® Rhinitis Spray, Xylometazoline nasal spray or a combination of both products. Rhinosinusitis symptoms were assessed, and nasal oedema and endonasal redness were determined by rhinoscopy. Patient diaries based on the validated SNOT (Sino Nasal Outcome Test) questionnaire evaluated rhinosinusitis parameters over time and influences of the disease on quality of life. Following treatment, investigators and patients judged the efficacy and tolerability.

Results
Ectoin® Rhinitis Spray diminished common rhinosinusitis symptoms such as nasal obstruction, nasal secretion, facial pain/headache, and smell/taste impairment. Upon treatment over 7 days, rhinosinusitis sum scores decreased statistically significantly (p < 0.001) by − 64.25%, which was comparable to that achieved with Xylometazoline-containing decongesting nasal spray (− 67.60%). No side effects were observed during treatment with Ectoin® Rhinitis Spray, whereas treatment with Xylometazoline-containing nasal spray resulted in nasal mucosa dryness. Concomitant treatment with both products diminished the development of nasal dryness and required fewer applications of Xylometazoline-containing nasal spray.

Conclusion
Ectoin® Rhinitis Spray is an effective, natural treatment option for acute rhinosinusitis, which may be used as monotherapy or as add-on treatment with a Xylometazoline-containing nasal spray. The concomitant use of Ectoin® Rhinitis Spray might reduce the needed dose of decongestant nasal spray and counteract bothersome side effects such as dry nasal mucosa.

Trial registration
The current study was registered in the ClinicalTrials.gov database under the identifier: NCT03693976 (date of registration: Oct 3, 2018).
A Deeper Union: From a Failed Project to the European Quality Lead
Authors: Aiginger Karl 
Published: June 2021

AbstractAfter President Trump’s departure, many expected that the transatlantic partnership would return to its previous state with the US playing a leading role. This article challenges that view. Instead, a new world order is foreseen, with different partnerships and spheres of influence. Europe can decide whether it wants to remain small and homogeneous or a larger but also more heterogenous Union that leads in welfare indicators such as life expectancy, fighting poverty and limiting climate change. Expanding this lead and communicating its uniqueness can empower Europe to combine enlargement and deepening, which appears unlikely without changes in governance and self-confidence.
Comparison of HPLC–DAD and LC–MS Techniques for the Determination of Tetracyclines in Medicated Feeds Using One Extraction Protocol
Authors: Patyra Ewelina , Kwiatek Krzysztof 
Published: June 2021

AbstractFour antibiotics, oxytetracycline, tetracycline, doxycycline, and chlortetracycline were separated and quantified in medicated feed. Tetracyclines from feed samples were extracted with 0.01 M citric buffer and acetonitrile (pH 3.0) and further purified with 0.45 µm syringe filters. The purified extract was separated on commercial RP-C18 column and analyzing using liquid chromatograph (LC) with two different detectors: diode array detector (DAD) and mass spectrometry (MS). These methods provided average recoveries from 72.2 to 101.8% for high pressure liquid chromatography (HPLC) with diode array detection and from 45.6 to 87.0% for liquid chromatography with mass spectrometry. The limit of detection in medicated feed ranged from 4.2 to 10.7 mg kg−1 for HPLC–DAD and 5.6 to 10.8 mg kg−1 for LC–MS. Our experiment showed that using the same extraction mixture we do not obtain the same recovery values for the analyzed compounds using two different detection techniques such as DAD and MS.
A Characterisation of Morita Algebras in Terms of Covers
Authors: Cruz Tiago 
Published: June 2021

AbstractA pair (A, P) is called a cover of EndA(P)op if the Schur functor HomA(P,−) is fully faithful on the full subcategory of projective A-modules, for a given projective A-module P. By definition, Morita algebras are the covers of self-injective algebras and then P is a faithful projective-injective module. Conversely, we show that A is a Morita algebra and EndA(P)op is self-injective whenever (A, P) is a cover of EndA(P)op for a faithful projective-injective module P.