bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPUTATIONAL REPURPOSED LIGANDS: POTENTIAL CURE FOR BLACK FUNGUS
Authors: Sreekumar Anagha , N Neha , Jayasankar Varsha , Dhipu Dhiya 
Published: October 2021

A rare but serious fungal infection, known as mucormycosis and colloquially as “ Black fungus”, is being detected relatively frequently among Covid 19 patients in some states of India. The disease often manifests in the skin and also affects the lungs and the brain. With no prompt medicines accessible the scourge brought about by the disease is expanding step by step. A ton of researchers are continuing for the potential medication up-and-comer that could help the medical care framework in this battle. We present a docking?based screening using a quantum mechanical scoring of a library built from approved drugs and compounds that Cefuroxime, Amoxicillin, Peramivir, Fluconazole, Itraconazol, Micafungin,Quercetin, Carvacrol, Xanthones,Curcumin,Thymol and Resveratrol with Proteins with PDB id 6VCT could display antibacterial activity against Black fungus. Clearly, these compounds should be further evaluated in experimental assays and clinical trials to confirm their actual activity against the disease. We hope that these findings may contribute to the rational drug design against Black fungus.
IMPLEMENTASI KONSELING KELOMPOK UNTUK MENGATASI PRAKTIK BULLYING
Authors: Azhari Azhari 
Published: October 2021

Masalah bullying pada peserta didik saat ini belum banyak menjadi perhatian dalam ruang pendidikan yang semakin memprihatinkan. Dari itu, penelitian ini bertujuan untuk melihat implementasi konseling kelompok sebagai upaya penyelesaian masalahan bullying pada siswa melalui penelitian lapangan (field research). Di dalamnya peneliti mencoba menguraikan pandangan berpikir yang menekankan pada fokus pengalaman subjektif melalui observasi terdapat naskah wawancara, catatan lapangan, foto, memo, dan dokumen lainnya, dengan menggunakan analisis Miles dan Huberman seperti reduction data (reduksi data), display data (penyajian data) dan verifikasi data (kesimpulan).
Hasil lapangan menunjukkan bahwa penyelesaian praktik bullying melalui konseling kelompok dikemas dalam empat sesi yaitu: Sesi I pembentukan kelompok. Sesi II peralihan, bertujuan agar terjadi umpan balik, kedekatan emosional antara peserta didik dengan konselor serta proses identifikasi masalah yang dihadapi peserta didik. Sesi III kegiatan berisi model materi diantaranya: model konseling kelompok berbasis pendekatan persuasif, model konseling kelompok berbasis pendekatan klasikal, model konseling berbasis pendekatan sosial, model konseling kelompok berbasis pendekatan Islam. Sesi IV penutup. Tujuan secara umum implementasi konseling kelompok untuk mengembalikan hubungan pikiran dan perasaan yang negatif kepada hubungan pikiran dan perasaan yang positif dalam membentuk prilaku baru sehingga ketika selanjutnya berhadapan dengan masalah, peserta didik mampu menemukan alternatif-alternatif positif dalam pencapaian jalan keluar. Kendala yang dihadapi diantaranya kendala internal peserta didik dan kendala internal konselor.
Bone Mineral Density and Body Mass Index in Postmenopausal Women
Authors: Nahar Kamrun , Al Zahid Bhuiyan Mohammed Mehedi , Mia Md Azzad , Hossain Arshad , Tasnim Humayra 
Published: October 2021

Osteoporosis is a typical medical issue that overwhelmingly influences postmenopausal women. A bone density test is the only test that can diagnose osteoporosis before a broken bone occurs. The aims of this study was to find out the relationship between bone mineral density (BMD) and body mass index (BMI) in postmenopausal females. This cross sectional descriptive study was carried out in the Institute of Nuclear Medicine and Allied Sciences (INMAS), Sylhet. Study subjects comprised of 117 postmenopausal women between ages 45 to 85 years, with a mean age of 60.8 ± 9.2 years, who underwent BMD scan from January 2018 to June 2019. Duration of the study was 5 months ( march 2019 to august 2019). BMD was measured by the MedilinkMedix DR system. Findings of BMD of right femur showed osteopenia and osteoporosis (low BMD) in most of the women with under weight (81.0%) about one third (32.3%) of normal body weight and few (16.7%) of them over weight. Contrarily in left femur, low BMD was found in 08 (80.0%), 25 (40.3%) and 6 (16.7%) among underweight, normal, overweight patients respectively. According to BMI compare to the lumbar spine, low BMD was found in 48 (77.4%), 10 (100 %), 20 (55.6%), 03 (33.3%) among normal, underweight, overweight, and obese patients respectively. Relationship among BMD and BMI was found statistically significant in the both femurs (p < 0.001) and lumbar spine (p = 0.02). Low BMD was more severe in the 65-74 years’ age group in both femurs 65.4% and 65-85 years’ age group in lumbar spine 84.6% compare to other groups. The findings of this study reveal that low BMI and aging are associated with bone loss. Routine BMD checking in postmenopausal women might be important to initiate an early clinical intervention for osteoporosis.
Bangladesh Med J. 2020 Sept; 49(3) : 22-28
Tek Parti Döneminde Suriye-Türkiye Dış Politikasında Fransa'nın Rolü
Authors: ÇOBAN KARABULUT Pakize 
Published: October 2021

Suriye’nin 1920 San Remo Konferansı’nda Fransa’nın mandası kabul edilmesi ile Türkiye, Suriye ile olan tüm ilişkilerini Fransa aracılığıyla yürütmüştür. Bu süreçte Fransa 1921 Ankara İtilafnamesi ile Türkiye’nin güney komşusu olmuştur. Fransa ile ilişkiler, Birinci Dünya Savaşı’nda Osmanlı Devleti’nin dağılmasının ardından Millî Mücadele döneminde Ankara Hükümeti ile güney cephesinde tekrar başlamıştır. Millî Mücadelenin başarıyla tamamlanması sonucu Fransa ile Lozan Barış Antlaşması hükümlerine göre 1923’ten itibaren ekonomik ve siyasî ilişkiler devam etmiştir. Fransa, Suriye’de iç politikada etnik ve dinî yönden parçalanmış bir yapı meydana getirdiği gibi; dış politikada da Suriye’nin komşularıyla iyi ilişkiler kurmasına engel olmuştur. Fransa’nın Türkiye üzerinden Osmanlı Devleti’ni canlandıracağı ile ilgili propagandaları, ülkedeki Kürtleri ve Ermenileri kışkırtması Suriye’nin etkin bir siyasî ve ekonomik politika takip etmesini engellemiştir.
Çalışmada tek parti döneminde Türkiye ve Suriye’nin siyasi ve ekonomik ilişkilerinde Fransa’nın rolü Türkiye’deki arşiv kaynakları üzerinden tartışılmıştır.
PELATIHAN PEMBUATAN HANDMADE SOAP METODE DINGIN PADA ANGGOTA PKK GUNUNG KELUA KOTA SAMARINDA
Authors: Sukawaty Yullia , Warnida Husnul 
Published: October 2021

We are using soap to remove dirt and bacteria in the skin. Traditionally, soap is made from vegetable oils and lye with simple home tools like pan and stove. Materials for handmade soap is not expensive and easily available, but it gives us a luxury bath. The reaction between fatty acid and lye in soap produces glycerin, a good humectant, to keep our skin supple and moist. Commercial soap manufacturer make it a practice to remove the glycerin that is produces during the saponification process. Hence, handmade soap does not dried out skin, like the commercial soap product. This activity aimed to (1) sharing information about PKK community in Gunung Kelua RT.37, and (2) to teach the community how to make a handmade soap with cheap materials that easily available. This activity used dialog method to discuss the benefit of soaps, soap materials, and sop-making practice. The practice of making soap is demonstrated in front of audience, and many audiences had a hand in practice. This activity then evaluated. The result is all audience has understood how to make soap and were able to practice soap-making.
PENINGKATAN PENGETAHUAN MASYARAKAT MENGENAI PERKEMBANGAN DAN PENYEBARAN DBD
Authors: Sudarwati Tri Puji Lestari , Fernanda M.A Hanny Ferry , Suryandari Mercyska 
Published: October 2021

This community service event was aimed to elevate the knowledge of local society regarding the current update of Aedes aegypti mosquito as a vector of Dengue Hemorrhagic Fever (DHF). Hence, it raised awareness of their role in breaking the disease transmission. Involving students as supporting team, this activity was carried out at Jemur Gayungan RW 01 by giving public counselling and mentoring for the larvae surveyor cadre (Jumantik). Abdimas, which has been done, adds to the knowledge of jumantik cadres about the proliferation and spread of dengue, so that jumantik cadres not only observe their environment but can also take action to break the chain of dengue spread.
EDUKASI GENERASI MUDA SIAP VAKSINASI COVID-19
Authors: Zulfa Ilil Maidatuz , Yunitasari Fitria Dewi 
Published: October 2021

Vaccination program for Covid-19 in Indonesia has been conducted since 13th of January 2021. However, the vaccination process has been accompanied by an increase false information that can lead to the decrease of public acceptance. Therefore, public education strengthening is a key concerns to succed the vaccination program. This was a report of public education strengthening activity conducted in April 2021 aimed to increase public awareness about Covid-19 vaccination program. There were 34 highschool students joined in the event. The result showed after joining the events 14,7% of students who refuse to support vaccinated program claim thet they are ready for vaccination. In conclusion, continuity in public education strengthening is essential to increase public acceptance about Covid-19 vaccination.
PELATIHAN PEMBARUAN FORMULA SEBAGAI UPAYA PENINGKATAN DAYA JUAL PRODUK SABUN CUCI TANGAN KEPADA UKM PUTAT JAYA, RT.05/RW 03 KELURAHAN PUTAT JAYA, KOTA SURABAYA (SEBAGAI UKM PERCONTOHAN PADA WILAYAH EKS. LOKALISASI)
Authors: Dipahayu Damaranie , Thalib Fitria Abbas 
Published: October 2021

Usaha Kecil Menengah (UKM) Putat Jaya Surabaya focus on soap business and has not found a standardized formula to ensure product repeatability from each time of production. Pengadian kepada Masyarakat (PkM) activity by Surabaya Pharmacy Academy was expected to be able to assist these UKM to share information through training on handwash liquid soap formulations that meet SNI standards. The content of this counselling not only about soap formula with and without plant oil and their formulation but also explained how to evaluate handwash liquid soap. The result of this PkM is additional knowledge for UKM Putat Jaya about handwash liquid soap formulas that met the requirements of the SNI and information of simple evaluation that can be done independently for the repeatability production. UKM Putat Jaya have been educated about handwash liquid soap that meets SNI standart.
Decellularized Whole-Organ Pre-vascularization: A Novel Approach for Organogenesis
Authors: Fathi Ibrahim , Imura Takehiro , Inagaki Akiko , Nakamura Yasuhiro , Nabawi Ayman , Goto Masafumi 
Published: October 2021

Introduction: Whole-organ decellularization is an attractive approach for three-dimensional (3D) organ engineering. However, progress with this approach is hindered by intra-vascular blood coagulation that occurs after in vivo implantation of the re-cellularized scaffold, resulting in a short-term graft survival. In this study, we explored an alternative approach for 3D organ engineering through an axial pre-vascularization approach and examined its suitability for pancreatic islet transplantation.Methods: Whole livers from male Lewis rats were decellularized through sequential arterial perfusion of detergents. The decellularized liver scaffold was implanted into Lewis rats, and an arteriovenous bundle was passed through the scaffold. At the time of implantation, fresh bone marrow preparation (BM; n = 3), adipose-derived stem cells (ADSCs; n = 4), or HBSS (n = 4) was injected into the scaffold through the portal vein. After 5 weeks, around 2,600 islet equivalents (IEQs) were injected through the portal vein of the scaffold. The recipient rats were rendered diabetic by the injection of 65 mg/kg STZ intravenously 1 week before islet transplantation and were followed up after transplantation by measuring the blood glucose and body weight for 30 days. Intravenous glucose tolerance test was performed in the cured animals, and samples were collected for immunohistochemical (IHC) analyses. Micro-computed tomography (CT) images were obtained from one rat in each group for representation.Results: Two rats in the BM group and one in the ADSC group showed normalization of blood glucose levels, while one rat from each group showed partial correction of blood glucose levels. In contrast, no rats were cured in the HBSS group. Micro-CT showed evidence of sprouting from the arteriovenous bundle inside the scaffold. IHC analyses showed insulin-positive cells in all three groups. The number of von-Willebrand factor-positive cells in the islet region was higher in the BM and ADSC groups than in the HBSS group. The number of 5-bromo-2′-deoxyuridine-positive cells was significantly lower in the BM group than in the other two groups.Conclusions: Despite the limited numbers, the study showed the promising potential of the pre-vascularized whole-organ scaffold as a novel approach for islet transplantation. Both BM- and ADSCs-seeded scaffolds were superior to the acellular scaffold.
Tannic Acid as a Natural Crosslinker for Catalyst-Free Silicone Elastomers From Hydrogen Bonding to Covalent Bonding
Authors: Kong Sen , Wang Rui , Feng Shengyu , Wang Dengxu 
Published: October 2021

The construction of silicone elastomers crosslinked by a natural crosslinker under a catalyst-free method is highly desirable. Herein we present catalyst-free silicone elastomers (SEs) by simply introducing tannic acid (TA) as a natural crosslinker when using poly (aminopropylmethylsiloxane-co-dimethylsiloxane) (PAPMS) as the base polymer. The crosslinked bonding of these SEs can be easily changed from hydrogen bonding to covalent bonding by altering the curing reaction from room temperature to heating condition. The formability and mechanical properties of the SEs can be tuned by altering various factors, including processing technique, the amount of TA and aminopropyl-terminated polydimethylsiloxane, the molecular weight and -NH2 content of PAPMS, and the amount of reinforcing filler. The hydrogen bonding was proved by the reversible crosslinking of the elastomers, which can be gradually dissolved in tetrahydrofuran and re-formed after removing the solvent. The covalent bonding was proved by a model reaction of catechol and n-decylamine and occurred through a combination of hydroxylamine reaction and Michael addition reaction. These elastomers exhibit good thermal stability and excellent hydrophobic property and can bond iron sheets to hold the weight of 500 g, indicating their promising as adhesives. These results reveal that TA as a natural product is a suitable “green” crosslinker for the construction of catalyst-free silicone elastomers by a simple crosslinking strategy. Under this strategy, TA and more natural polyphenols could be certainly utilized as crosslinkers to fabricate more organic elastomers by selecting amine-containing polymers and further explore their extensive applications in adhesives, sealants, insulators, sensors, and so forth.
Reduction of Radiation Exposure in Atrioventricular Nodal Reentrant Tachycardia Ablations Using an Electroanatomical Mapping System With Fluoroscopy Integration Module
Authors: Blockhaus Christian , Gülker Jan-Erik , Bufe Alexander , Seyfarth Melchior , Koektuerk Buelent , Shin Dong-In 
Published: October 2021

Introduction: Atrioventricular nodal reentrant tachycardia (AVNRT) is a common supraventricular tachycardia. Current guidelines recommend electrophysiology study (EPS) and ablation, which have been proven to show high success rates with very low complication rates. Usually, ablation of AVNRT is performed conventionally using only fluoroscopy. Electroanatomical mapping systems (EMS) are widely used in complex arrhythmias. One of their advantages is their potential in decreasing the need of fluoroscopy time (FT). In this study we analyzed patients undergoing either conventional AVNRT ablation or by using an EMS with a fluoroscopy integrating system (FIS).Materials and Methods: We included 119 patients who underwent AVNRT ablation in our study. Eighty-nine patients were ablated conventionally using only fluoroscopy, 30 patients were ablated using EMS + FIS.Results: We found that the use of EMS + FIS led to a significant reduction of FT (449.90 ± 217.21 vs. 136.93 ± 109.28 sec., p &lt; 0.001) and dose-area-product (DAP, 268.27 ± 265.20 vs. 41.07 ± 27.89 μGym2, p &lt; 0.001) without affecting the procedure time (PT, 66.55 ± 13.3 vs. 67.33 ± 13.81 min, p = 0.783). Furthermore, we found no significance with regard to complications.Conclusion: The use of EMS+FIS is safe and feasible. It leads to a significant reduction of both FT and DAP without affecting PT and safety. Hence, EMS + FIS is beneficial for both the operator and the patients by reducing the radiation exposure.
The Importance of Size and Location Within Gregarious Populations of Ernietta plateauensis
Authors: Gibson Brandt M. , Darroch Simon A.F. , Maloney Katie M. , Laflamme Marc 
Published: October 2021

Ernietta plateauensis is a semi-infaunal macroscopic eukaryote of unknown affinities common in latest Ediacaran (∼548–539 Ma) shallow marine settings in Namibia. The discovery of in-situ assemblages of Ernietta has demonstrated that these organisms lived in aggregated populations, while studies employing computational fluid dynamics (CFD) modeling have supported the hypothesis that these organisms were likely behaving as gregarious suspension feeders, analogous to many extant invertebrate phyla in present-day marine environments. Careful census and measurement of individuals within these in-situ populations offers an opportunity to examine how their size and location within a larger population affect nutrient delivery dynamics. In this study, we build on previous work by simulating fluid flow over aggregations of Ernietta comprising individuals of disparate sizes, and additionally reconstruct a population of Ernietta preserved in-situ from Farm Hansburg, Namibia. We use a combination of stationary and time-dependent CFD to reconstruct nutrient carrying flow paths, and compare the efficiency with which nutrients are partitioned between individuals of different shapes and sizes. Our results demonstrate that smaller Ernietta experience limited recirculation within their cavities compared to larger individuals. Furthermore, in spatially-accurate distributions, reduced recirculation is limited to isolated individuals of any size, while smaller individuals found downstream of larger ones receive enhanced cavity mixing. These reconstructed flow patterns illustrate that the disadvantage associated with small size is apparently mediated by location within the overall aggregation, suggesting a complex interplay of controls on feeding efficiency. This in turn suggests that aggregations of adult Ernietta would likely have performed a ‘nursery’ function, creating localized conditions ideal for the settlement and growth of younger individuals.
Focal Thyroid Incidentalomas on 18F-FDG PET/CT: A Systematic Review and Meta-Analysis on Prevalence, Risk of Malignancy and Inconclusive Fine Needle Aspiration
Authors: de Leijer J. F. , Metman M. J. H. , van der Hoorn A. , Brouwers A. H. , Kruijff S. , van Hemel B. M. , Links T. P. , Westerlaan H. E. 
Published: October 2021

BackgroundThe rising demand for 18F-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET/CT) has led to an increase of thyroid incidentalomas. Current guidelines are restricted in giving options to tailor diagnostics and to suit the individual patient.ObjectivesWe aimed at exploring the extent of potential overdiagnostics by performing a systematic review and meta-analysis of the literature on the prevalence, the risk of malignancy (ROM) and the risk of inconclusive FNAC (ROIF) of focal thyroid incidentalomas (FTI) on 18F-FDG PET/CT.Data SourcesA literature search in MEDLINE, Embase and Web of Science was performed to identify relevant studies.Study SelectionStudies providing information on the prevalence and/or ROM of FTI on 18F-FDG PET/CT in patients with no prior history of thyroid disease were selected by two authors independently. Sixty-one studies met the inclusion criteria.Data AnalysisA random effects meta-analysis on prevalence, ROM and ROIF with 95% confidence intervals (CIs) was performed. Heterogeneity and publication bias were tested. Risk of bias was assessed using the quality assessment of diagnostic accuracy studies (QUADAS-2) tool.Data SynthesisFifty studies were suitable for prevalence analysis. In total, 12,943 FTI were identified in 640,616 patients. The pooled prevalence was 2.22% (95% CI = 1.90% - 2.54%, I2 = 99%). 5151 FTI had cyto- or histopathology results available. The pooled ROM was 30.8% (95% CI = 28.1% - 33.4%, I2 = 57%). 1308 (83%) of malignant nodules were papillary thyroid carcinoma (PTC). The pooled ROIF was 20.8% (95% CI = 13.7% - 27.9%, I2 = 92%).LimitationsThe main limitations were the low to moderate methodological quality of the studies and the moderate to high heterogeneity of the results.ConclusionFTI are a common finding on 18F-FDG PET/CTs. Nodules are malignant in approximately one third of the cases, with the majority being PTC. Cytology results are non-diagnostic or indeterminate in one fifth of FNACs. These findings reveal the potential risk of overdiagnostics of FTI and emphasize that the workup of FTI should be performed within the context of the patient’s disease and that guidelines should adopt this patient tailored approach.
Diagnosis of Pituitary Adenoma Biopsies by Ultrahigh Resolution Optical Coherence Tomography Using Neuronal Networks
Authors: Micko Alexander , Placzek Fabian , Fonollà Roger , Winklehner Michael , Sentosa Ryan , Krause Arno , Vila Greisa , Höftberger Romana , Andreana Marco , Drexler Wolfgang , Leitgeb Rainer A. , Unterhuber Angelika , Wolfsberger Stefan 
Published: October 2021

ObjectiveDespite advancements of intraoperative visualization, the difficulty to visually distinguish adenoma from adjacent pituitary gland due to textural similarities may lead to incomplete adenoma resection or impairment of pituitary function. The aim of this study was to investigate optical coherence tomography (OCT) imaging in combination with a convolutional neural network (CNN) for objectively identify pituitary adenoma tissue in an ex vivo setting.MethodsA prospective study was conducted to train and test a CNN algorithm to identify pituitary adenoma tissue in OCT images of adenoma and adjacent pituitary gland samples. From each sample, 500 slices of adjacent cross-sectional OCT images were used for CNN classification.ResultsOCT data acquisition was feasible in 19/20 (95%) patients. The 16.000 OCT slices of 16/19 of cases were employed for creating a trained CNN algorithm (70% for training, 15% for validating the classifier). Thereafter, the classifier was tested on the paired samples of three patients (3.000 slices). The CNN correctly predicted adenoma in the 3 adenoma samples (98%, 100% and 84% respectively), and correctly predicted gland and transition zone in the 3 samples from the adjacent pituitary gland.ConclusionTrained convolutional neural network computing has the potential for fast and objective identification of pituitary adenoma tissue in OCT images with high sensitivity ex vivo. However, further investigation with larger number of samples is required.