bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative Electroencephalogram Frontal Low Alpha Power for Predicting Postoperative Delirium in Elderly Patients after Orthopedic Surgery: A Prospective Cohort Study
Authors: Dai Yuchen , Shen Changli , Shi Kaikai , Liu Qingren , Qiu Xiaodong , Sun Jie 
Published: December 2024

AIM: Postoperative delirium (POD) is a common complication with significant adverse effects in elderly patients. Electroencephalography (EEG) provides a promising approach for predicting the risk of POD. This study aims to elucidate the correlation between intraoperative EEG spectrum and the incidence of POD in elderly patients undergoing orthopedic surgery.
METHODS: A single-center prospective observational cohort study was conducted at Zhongda Hospital, Southeast University, from September 2022 to March 2023, registered on Chinese Clinical Trail Registry (ChiCTR2300069548). Among the 172 patients who underwent orthopedic surgery, 125 completed the study with available data. Preoperative baseline cognitive function was assessed using the mini-mental state examination (MMSE). An intraoperative 4-channel EEG was recorded. Total power spectra and power spectral density for beta, alpha, theta, and delta bands were calculated. Spectral edge frequency, burst suppression ratio, and patient state index were directly extracted from the EEG monitor. The primary outcome was POD, assessed using a 3-minute Diagnostic Interview for Confusion Assessment Method (CAM)-Defined Delirium scale or the CAM for the Intensive Care Unit. Patients were divided into POD and non-postoperative delirium (non-POD) groups. Logistic regression analysis was conducted to evaluate the independent predictive effect of intraoperative spectral distribution and other quantitative EEG data for POD.
RESULTS: The incidence of delirium within 72 hours after surgery was 8.8%. Compared to the non-POD group, the POD group showed significantly lower absolute power in the beta [0.06 (0.03, 0.09) dB vs 0.14 (0.08, 0.26) dB, p < 0.001], alpha [0.41 (0.25, 0.71) dB vs 1.24 (0.55, 2.57) dB, p = 0.008], and theta [0.77 (0.44, 1.01) dB vs 1.19 (0.72, 2.02) dB, p = 0.035] bands. Logistic regression analysis identified several independent risk factors for POD, including lower intraoperative alpha power [odds ratio (OR) 10.210, 95% confidence interval (CI) 1.233–84.568, p = 0.031], advanced age (OR 7.713, 95% CI 1.022–58.204, p = 0.048), preoperative anemia (OR 6.636, 95% CI 1.091–40.358, p = 0.040), and preoperative depression (OR 10.089, 95% CI 1.029–98.909, p = 0.047). In contrast, higher preoperative MMSE scores appeared to be a protective factor for POD (OR 0.130, 95% CI 0.021–0.820, p = 0.030).
CONCLUSIONS: Intraoperative EEG frontal low alpha power demonstrated a significant independent association with POD in elderly patients after orthopedic surgery. This parameter may serve as an intraoperative neurophysiological marker of cerebral vulnerability to POD. Additionally, advanced age, lower preoperative MMSE scores, preoperative anemia, and preoperative depression were independent risk factors for POD.
CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry (ChiCTR2300069548).
Efficacy Analysis of Modified Single-Incision Surgery for Repair of Pediatric Chest Wall Defects: A Retrospective Cohort Study
Authors: Liu Jinlong , Liu Xiaoying , Wu Yong , Zhang Rufang , Tao Qilin , Wang Qiang 
Published: December 2024

AIM: This study aims to compare the efficacy of modified single-incision surgery with that of traditional modified Ravitch surgery for the repair of pectus excavatum in pediatric patients.
METHODS: In this retrospective study, we included patients who underwent surgical correction for sternal depression from January 2015 to December 2020 across four major medical centers. Patients were categorized into two specific groups on the basis of the surgical technique employed: the modified single-incision surgery group, which comprised patients treated using the novel single-incision approach, and the traditional modified Ravitch surgery group, which included patients who received the conventional Ravitch surgery with multiple incisions. This study only included patients in the age range of 10 to 18 years, diagnosed with moderate to severe pectus excavatum, and lacked remarkable comorbid conditions that could influence surgical outcomes. Comprehensive data on preoperative characteristics, intraoperative variables, and postoperative results were collected for analysis.
RESULTS: The modified single-incision surgery group showed significantly lower mean blood loss, mean operating time, mean hospital stay, postoperative drainage rate, postoperative mean Haller index and mean Haller index after bar removal compared to the traditional modified Ravitch surgery group (p < 0.05). Furthermore, the surgical outcomes were significantly better in the modified single-incision surgery group (p = 0.010) than in the traditional modified Ravitch surgery group. The modified single-incision surgery group also had a significantly lower incidence of postoperative complications, including pneumothorax, pleural effusion, pulmonary infection, bar rejection, and bar flipping and displacement (p < 0.05), than the traditional modified Ravitch surgery group. The modified single-incision surgery group showed significantly greater improvement in sternal depression depth compared to the traditional modified Ravitch surgery group (p = 0.031). Corrected symmetry was significantly better in the modified single-incision surgery group (p = 0.037). The overall satisfaction of patients in the modified single-incision surgery group was significantly higher than that in the traditional modified Ravitch surgery group (p = 0.011).
CONCLUSIONS: The modified single-incision procedure for the treatment of pectus excavatum offers considerable advantages over the traditional modified Ravitch surgery. The findings of this study suggest that the modified single-incision procedure is a safe and effective alternative for the correction of pectus excavatum.
Enhancing Post-Surgical Wound Care in Anorectal Diseases: A Comparative Study of Advanced Convolutional Neural Network (CNN) Architectures for Image Classification and Analysis
Authors: Zhang Qiaolan , Chen Zhaobo , Hu Shunfang , Bao Xinkun 
Published: December 2024

AIM: Anorectal diseases, often requiring surgical intervention and careful post-operative wound management, pose substantial challenges in healthcare. This study presents a novel application of artificial intelligence, specifically machine learning, aimed at improving the classification and analysis of post-surgical wound images. By doing so, it seeks to enhance patient outcomes through personalized and optimized wound care strategies.
METHODS: This research utilizes convolutional neural networks (CNNs) and employs three advanced architectures—MobileNet, ResNet50, and Inception-v4—to detect and classify key characteristics of post-surgical wounds, including size, location, severity, and tissue type involved. Additionally, the study integrates Gradient-weighted Class Activation Mapping (Grad-CAM) technology to provide interpretative insights into the decision-making processes of these algorithms, offering a deeper understanding of model predictions.
RESULTS: The effectiveness of the employed CNN architectures was assessed based on accuracy, precision, and recall metrics. The findings demonstrate that Inception-v4, in particular, exhibits superior performance across all evaluated metrics, underscoring its potential in clinical applications. Grad-CAM visualizations further clarified the rationale behind the model's decisions, enhancing the interpretability of the results.
CONCLUSIONS: The integration of machine learning technologies in the classification and analysis of wound images represents a significant advancement in medical image analysis and AI-driven healthcare solutions. This research not only enhances the technical capabilities of AI applications in healthcare but also improves the precision of post-operative care in anorectal surgery, ultimately contributing to better treatment outcomes.
Proliferative Myositis of the Breast in a Patient with Contralateral Phyllodes Tumor: A Unique Pseudomalignant Lesion
Authors: Kuş Silav Zuhal 
Published: December 2024

AIM: We report a case of proliferative myositis (PM) of the breast, which is the second reported in the English literature.
CASE PRESENTATION: A 49-year-old woman underwent surgery due to a fibroadenoma in the right and phyllodes tumor in the left breast. One month after these surgeries, a right breast mass rapidly grew at the surgical site, and biopsy did not provide a diagnosis. The lesion's rapid growth and high cellularity led to a suspicion of malignancy, and the mass was surgically removed. The immunohistochemical markers used were estrogen receptor (ER), S100, smooth muscle actin (SMA), desmin, pan-cytokeratin, Myoblast Determination Protein 1 (MyoD1), myogenin, caldesmon, calretinin, CD34, Anaplastic Lymphoma Kinase (ALK), P53, P63, and Ki67. A low Ki67 index and mitosis, lack of staining with rhabdomyosarcoma markers, and a typical checkerboard pattern ruled out malignancy. The diagnosis was PM.
CONCLUSIONS: This case emphasizes the importance of recognizing pseudomalignant breast masses to avoid catastrophic overtreatment.
ӨЗГЕШЕ ӨРНЕК ИЕСІ
Authors: Мұсаев Алпысбай 
Published: December 2024

The article examines the work of an outstanding representative of modern Kazakh literature, Hero of Labor of Kazakhstan, Laureate of the State Prize Akim Tarazi from the point of view of the requirements of literary criticism.
The article sets the goal of teaching and studying the creativity of Akim Tarazi and studying the prose, dramatic works of the writer from the point of view of chronological and comparative historical, hermeneutic methods.
With the help of these methods, the author's ideas about time and space, about human existence and ways of modeling the real world and the inner world of his characters are considered. The writer shows the social types, such as the worm, that penetrate into the core of society through his work. These types are designed to draw the reader's attention to how much they influenced the Kazakh identity.In addition, the works reveal the socio-social, cultural nature of the complex problems of Kazakh society. The works of Akim Tarazi reflect the multilevel situations of national existence and the thought of freedom. The scientific and practical value of the research is measured by the fact that in Kazakh literary studies, certain judgments of the Soviet period are overestimated from the standpoint of a modern independent country, and also contribute to the improvement of the methodological and theoretical aspect of the Domestic literary branch.
Study of blood testosterone in patients with chronic prostatitis
Authors: Kalinkin D. E. , Boshchenk V. S. 
Published: December 2024

Introduction: Chronic prostatitis is a polyetiological disease with a complex pathogenesis, significantly reducing the quality of life of men. One of the factors in the pathogenesis of prostatitis is testosterone deficiency, but its role requires further study.Purpose of the study: to study the level of testosterone and its relationship with the main clinical, laboratory and instrumental parameters in patients with chronic prostatitis.Materials and Methods: A retrospective analysis of the examination results of 393 patients suffering from chronic prostatitis (categories II, IIIA and IIIB according to the NIH classification, 1995) was performed. The average age of the patients was 44.33±10.01 years. The statistical significance of the difference (p) in the sum of points on the NIH-CPSI scale, the content of leukocytes and pathogenic microflora content in the secretion of the prostate gland, the maximum volumetric flow rate of urination and the volume of residual urine in patients with blood testosterone levels < 8 , 8-12 and >12 nmol/l was estimated. The relationship (correlation coefficient, r) between testosterone levels and the above parameters was also assessed.Study results: the proportion of patients with testosterone levels below 12 nmol/L was 31.04%. The average blood testosterone level was above the threshold (12 nmol/L) and did not differ statistically significantly in patients with different CP/CPPS categories. In patients with blood testosterone levels < 8 nmol/L, the white blood cell count in prostate secretions was statistically significantly higher than in patients in other groups (p<0.05); in addition, patients with blood testosterone levels below 8 nmol/L had the lowest urinary flow rate and the highest residual urine volume (compared to the other two groups), but this difference was not statistically significant (p >0.05). A negative correlation was found between the testosterone level, on the one hand, and the number of points on the NIH-CPSI scale and the content of leukocytes in the prostate gland secretion, on the other.Conclusion: it is necessary to continue the study on an expanded cohort of patients with the targeted formation of groups with low and «subnormal» blood testosterone content.
Primary reconstruction of epispadias in exstrophy: modified Cantwell technique with external rotation of the corpora cavernosa
Authors: Nikolaev V. V. , Demin N. V. , Ladygina E. A. , Sarukhanyan O. O. 
Published: December 2024

Objective: to present a modification of the Cantwell epispadias reconstruction technique aimed at lengthening and straightening the penile shaft.Patients and methods: a prospective follow-up of all boys with classic exstrophy who underwent the proposed technique was conducted. Inclusion criteria were patients with exstrophy with a postoperative followup period of more than 12 months, who had a urethral plate longer than 15 mm.Results: between November 2021 and June 2023, penile reconstruction was performed on 36 patients with exstrophy. Of this cohort, 14 boys aged 12 to 47 months met the inclusion criteria and underwent a modified reconstruction. The surgery and the postoperative period were not accompanied by serious complications. In the medium term, penile appearance, erectile shape, and urination were assessed both in an outpatient setting and by photo and video recording.Conclusion: the presented technique, applied in a homogeneous group of patients with classic bladder exstrophy, allowed to achieve penile elongation, improved appearance, erectile function, and elimination of dorsal curvature.
Spermatology defects in patients with male infertility associated with fibrous sheath dysplasia of the sperm flagellum
Authors: Khayat S. Sh. , Bragina E. E. , Kurilo L. F. , Sorokina T. M. , Solovova O. А. , Shtaut M. I. , Chernykh V. B. 
Published: December 2024

Dysplasia of the fibrous sheath (DFS) is a specific structural abnormality of sperm, which is characterized by disorganization of the transverse ribs and vertical columns of the fibrous membrane and leads to impaired motility and morphology of sperm, impaired male fertility.The purpose of this work was a comprehensive spermiological study of patients with infertility associated with DFS.Material and methods. Twenty-six unrelated patients with male infertility were examined, in whom, according to the results of transmission electron microscopy of spermatozoa (TEM), a high content of gametes with DFO was detected (group I – 50-79%, n=14; group II – 80-100%, n=12). Standard semen examination was performed according to WHO laboratory manual (2010).Results. Total asthenozoospermia was detected in 11 (42%) patients and total teratozoospermia in 21 (81%) patients.Increased content of spermatozoa with spontaneous acrosome reaction in 85% of patients with DFS and incomplete chromatin condensation in 38% were detected. Heterogeneous defects of axoneme structure were found in 88% of samples. In 42% of cases, dysplastic changes in the fibrous sheath were combined with the absence of the central pair of microtubules of the axoneme of the sperm flagellum.Conclusion. In patients with severe dysplasia of the fibrous sheath, a decrease in motile and morphologically normal sperm, combined with their reduced concentration (oligoasthenoteratozoospermia), was revealed. DFS is often combined with an increased content of sperm with a reacted acrosome and heterogeneous defects in the axoneme structure, including primary ciliary dyskinesia. In patients with high percentage DFS, severe decrease in sperm motility and morphology was found, in most in combination with their reduced concentration (oligoastenotheratozoospermia). An increased percentage of gametes with a reacted acrosome and heterogeneous defects in the axoneme structures characteristic of primary ciliary dyskinesia also was revealed.
Caracterización del perfil lipídico en población del Laboratorio Clínico del Área de Salud Florencia, período 2015-2016
Authors: Mejía Jiménez Annia 
Published: December 2024

Las dislipidemias constituyen un factor de riesgo modificable en el desarrollo de enfermedad cardiovascular. El objetivo del estudio fue determinar la prevalencia y distribución de las dislipidemias en la población del Laboratorio Clínico del Área de Salud Florencia, 2015-2016. Metodología: estudio descriptivo transversal en población de 6 321 individuos. Se realizó estimación de medidas de morbilidad (prevalencia), de resumen y frecuencia, de tendencia central y de dispersión, mediante herramientas Microsoft Excel® y Epinfo® 7.2. Resultados: la prevalencia fue de 24,3 %, con mayor afectación del sexo femenino y del grupo de 45 a 64 años. El 97,0 % de los individuos presentó alteraciones en los niveles de lípidos; 88,5 % hipercolesterolemia, 60,7 % hipoalfalipoproteinemia, 48,3 % hipertrigliceridemia y 40,9 % dislipidemia mixta. Un 9,5 % presentó valores de HDL colesterol superiores a 60 mg/dL; de este total, 84,4 % eran mujeres. En el caso de las personas con hipertrigliceridemia, el 25,6 % tuvo valores en el rango alto, 19,6 % en el limítrofe alto y un 1,6 % en el rango de muy alto, distribuido de manera muy similar en hombres (n=51) y mujeres (n=53). En la determinación de LDL colesterol y colesterol no HDL, se encontró que solo un 14,1 % de los analizados no presentó hipercolesterolemia, un 31,1 % (n=1 969) en el rango de limítrofe alto, un 29,5 % (n=1 868) en el de cercano a óptimo, el 16,1 % (n=1 020) en rango alto y un 9,0 % con un rango muy alto (n=571). Conclusión: se encontró una alta prevalencia de dislipidemia similar a la reportada para Costa Rica. La información aportada podría utilizarse en la priorización de intervenciones a nivel local.
The Comprehensive Literature Review of Surgical Management of Omphalocele
Authors: Yosie Yulanda Putra  , Ririn Azhari  
Published: December 2024

Background: The surgical management of omphalocele has undergone significant evolution over the past decade, with various studies contributing to a deeper understanding of treatment modalities and outcomes. Literature Review: In developing countries, challenges persist, particularly in managing ruptured omphaloceles where resources are limited. The adaptation of surgical techniques, such as employing simple suture methods in the absence of advanced materials, underscores the need for flexibility in surgical management (Komlatsè Akakpo-Numado et al., 2012). Furthermore, innovative conservative management approaches have shown promise, with gentian violet yielding satisfactory survival rates and reduced hospital stays, emphasizing the role of a multidisciplinary team in optimizing care (Rahman Mitul & Ferdous, 2012). The importance of individualized treatment plans is reinforced by findings from a tertiary care center, which advocate for conservative approaches in cases of giant omphalocele, utilizing staged management strategies that prioritize patient safety . Moreover, systemic inflammation's role in pulmonary hypertension related to isolated giant omphalocele further emphasizes the need for prenatal diagnosis and careful postnatal management, suggesting that a "paint-and-wait" approach can be beneficial (Teillet et al., 2022). Conclusion: In conclusion, the surgical management of omphalocele encompasses a variety of strategies that reflect the complexity of the condition and the necessity for individualized care. The literature collectively emphasizes the importance of adapting surgical techniques to specific patient needs, the benefits of conservative management in certain contexts, and the critical role of multidisciplinary teams in improving patient outcomes.
PENGEMBANGAN SUSTAINABLE TOURISM PADA EVENT CONFERENCE BERDASARKAN FOOD WASTE DI HOTEL X SANUR
Authors: Sinaga Firman , Amir Firlie Lanovia , Hendrajana I Gusti Made Riko , Devi Ni Kadek Sintya Loka 
Published: December 2024

Sustainable tourism sangat penting pada saat ini khususnya mencegah lingkungan agar lebih baik khususnya dalam mengelola food waste seperti pada kegiatan dalam sebuah event disampaikan oleh Akın Aksu1 et al (2016) yaitu para peserta sangat mendukung adanya eco-friendly green meetings atau sustainable event di dunia yang menghasilkan hemat makanan. Sedangkan di eropa lebih sustainable dikarenakan negara eropa telah memiliki strategi untuk zero waste seperti melakukan donasi makanan sisa, membuat bio methanisation process, compost donated to local farmers, EMAS Steering Committee (2018). Sungguh menyedihkan bahwa Indonesai memiliki urutan 77 dari 127 negara tentang hunger problem, Ni Gusti Ayu Dyah Satyawati et al. (2024) The Global Hunger Index. Penelitian dilakukan di Prime Plaza Hotel Sanur pada dua lokasi yaitu Hotel X Sanur dari bulan July sampai November 2024 dengan metode pengumpulan data menggunakan metode survey dengan menyebarkan kuesioner, terhadap chef dan food and beverage manager dan beberapa karyawan di steward dan waiter. Hasil penelitian agar sisa makanan layak makan diberikan kepada manusia sedangkan yang tidak layak makan dijadikan kompos serta makanan tetap di timbang.
NOTAS SOBRE A CRIAÇÃO DE UMA “ESCOLA DE MINEIROS” NO FINAL DO SÉCULO XIX
Authors: Ribeiro Jotta Carlos Augusto 
Published: December 2024

Este artigo tem como principal campo de estudo a Escola de Minas de Ouro Preto, inaugurada em 1876. Tal ação teve como protagonista o geólogo e mineralogista francês Claude Henri Gorceix que empreendeu esforços para implantar seu projeto pedagógico em Ouro Preto. Objetivou-se com esses traçar informações sobre a abertura de uma escola de engenharia em Ouro Preto no final do século XIX bem como seus principais desdobramentos como a formação de coleções de instrumentos científicos e os registros acadêmicos gerados pelo corpo de professores e alunos. No desenvolvimento deste trabalho, considerou-se o percurso da Escola de Minas de Ouro Preto, sua fundação e a formação do plano de aulas aplicado para a formação de engenheiros na província de Minas Gerais. A proposta adotou um percurso metodológico cujo processo é pautado em uma revisão bibliográfica, levantamento de fonte de informação e cruzamento de dados.