bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-stage revision for the infected total knee arthroplasty
Authors: Razii Nima , Clutton Juliet M. , Kakar Rahul , Morgan-Jones Rhidian 
Published: May 2021

AimsPeriprosthetic joint infection (PJI) is a devastating complication following total knee arthroplasty (TKA). Two-stage revision has traditionally been considered the gold standard of treatment for established infection, but increasing evidence is emerging in support of one-stage exchange for selected patients. The objective of this study was to determine the outcomes of single-stage revision TKA for PJI, with mid-term follow-up.MethodsA total of 84 patients, with a mean age of 68 years (36 to 92), underwent single-stage revision TKA for confirmed PJI at a single institution between 2006 and 2016. In all, 37 patients (44%) were treated for an infected primary TKA, while the majority presented with infected revisions: 31 had undergone one previous revision (36.9%) and 16 had multiple prior revisions (19.1%). Contraindications to single-stage exchange included systemic sepsis, extensive bone or soft-tissue loss, extensor mechanism failure, or if primary wound closure was unlikely to be achievable. Patients were not excluded for culture-negative PJI or the presence of a sinus.ResultsOverall, 76 patients (90.5%) were infection-free at a mean follow-up of seven years, with eight reinfections (9.5%). Culture-negative PJI was not associated with a higher reinfection rate (p = 0.343). However, there was a significantly higher rate of recurrence in patients with polymicrobial infections (p = 0.003). The mean Oxford Knee Score (OKS) improved from 18.7 (SD 8.7) preoperatively to 33.8 (SD 9.7) at six months postoperatively (p < 0.001). The Kaplan-Meier implant survival rate for all causes of reoperation, including reinfection and aseptic failure, was 95.2% at one year (95% confidence interval (CI) 87.7 to 98.2), 83.5% at five years (95% CI 73.2 to 90.3), and 78.9% at 12 years (95% CI 66.8 to 87.2).ConclusionOne-stage exchange, using a strict debridement protocol and multidisciplinary input, is an effective treatment option for the infected TKA. This is the largest single-surgeon series of consecutive cases reported to date, with broad inclusion criteria. Cite this article: Bone Jt Open 2021;2(5):305–313.
Qualitative and quantitative analysis of steatite using calibration-free laser-induced breakdown spectroscopy in conjunction with x-ray fluorescence spectroscopy and Fourier-transform infrared spectroscopy
Authors: Fahad Muhammad , Shahzad Asim , Ali Sajjad , Shah Khizar Hussain 
Published: May 2021

The qualitative and quantitative study of raw steatite was carried out using a pulsed nanosecond Nd:YAG laser set to fundamental harmonic (1064 nm) at atmospheric pressure. To cross-validate the data, x-ray diffraction (XRD), x-ray fluorescence (XRF) spectroscopy, and Fourier-transform infrared spectroscopy (FTIR) were used. The analysis of optical emission spectra in the wavelength range 200–720 nm showed the existence of silica (Si), magnesium (Mg), and calcium (Ca). The plasma temperature and electron number density were estimated using the Boltzmann plot and Stark-broadening line profile methods, with results at 4906 K and

1.47

×

10

17

c
m

−
3

, respectively. The quantitative study was carried out using the calibration-free laser-induced breakdown spectroscopy (CF-LIBS) process, assuming local thermodynamic equilibrium and an optically thin plasma, and the following results were obtained: Si = 63.37%, Mg = 35.95%, and Ca = 0.671%. The quantitative findings obtained using the CF-LIBS approach were consistent with those obtained using XRD, XRF, and FTIR, demonstrating the applied methods’ potential to be effective and complementary for the qualitative and quantitative study of multiphase raw steatite.
A follow-up study (2007–2018) on American Tegumentary Leishmaniasis in the municipality of Caratinga, Minas Gerais State, Brazil: Spatial analyses and sand fly collection
Authors: Neves Rafael L. , Cardoso Diogo T. , Rêgo Felipe D. , Gontijo Célia M. F. , Barbosa David S. , Soares Rodrigo P. 
Published: May 2021

BackgroundThe municipality of Caratinga is an important endemic area for American Tegumentary Leishmaniasis (ATL) and no epidemiological studies were performed during the past two decades. Here, we analyzed the epidemiological situation and the geographical distribution of ATL cases in the municipality of Caratinga from 2007 to 2018 using geographic information systems (GIS). Also, we evaluated the impact of several demographic parameters in ATL distribution and the sand flies incriminated in its transmission.MethodsAll demographic information (gender, age, educational level, clinical form, diagnostic criteria and case evolution) used in this study was retrieved from the public health archives and confirmed in the State Health Services databases. All cases were analyzed using GIS software based on ATL distribution. Also, non-systematic sand fly collections and molecular detection ofLeishmaniawere performed in the hotspots.Results and conclusionsDuring the period, ATL cases continued and increased especially in the past years (2016–2018). Hotspots included urban Caratinga areas and the districts of Patrocínio de Caratinga and Sapucaia. The speciesNyssomyia whitmani,Nyssomyia intermedia,Migonemyia migoneiandEvandromyia cortelezziicomplex were captured. However, ITS1-PCR did not detectLeishmaniaDNA in those insects. Based on our analyses, urbanization of ATL in Caratinga has occurred in the past years. Due to the increase in the number of cases and vectors presence, it is recommended that health authorities focus on control measures in the most affected areas (Patrocínio of Caratinga and Sapucaia districts and urban Caratinga).
The efficacy of manual therapy for chronic obstructive pulmonary disease: A systematic review
Authors: Roh Ji-Ae , Kim Kwan-Il , Jung Hee-Jae 
Published: May 2021

BackgroundManual therapy (MT) can be beneficial in the management of chronic obstructive pulmonary disease (COPD). However, evidence of the efficacy of MT for COPD is not clear. Therefore, we aimed to review the effects of MT, including Chuna, in people diagnosed with COPD.MethodsMEDLINE via PubMed, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), China National Knowledge Database (CNKI), KoreaMed, Korean Medical Database (KMbase), and Oriental Medicine Advanced Searching Integrated System (OASIS) were searched. Randomized controlled trials (RCTs) and crossover RCTs were included. The main inclusion criteria were COPD diagnosis (forced expiratory volume in the first second [FEV1]/forced vital capacity [FVC] < 0.70). The primary outcomes were lung function and exercise capacity. The secondary outcomes were symptoms, quality of life (QoL), and adverse event (AE)s. Studies reporting one or both of the primary outcomes were included. The Cochrane RoB 2.0 tool was used to assess the risk of bias. Data synthesis and analysis were conducted according to the trial design.ResultsOf the 2564 searched articles, 13 studies were included. For the primary outcomes, the effect of MT on pulmonary function and exercise capacity in COPD was partly significant but could not be confirmed due to the limited number of studies included in the subgroups. For the secondary outcomes, no definitive evidence regarding the improvement of symptoms and QoL was found, and some minor adverse effects were reported.ConclusionsThere is insufficient evidence to support the role of MT in the management of COPD. High-quality studies are needed to thoroughly evaluate the effect of MT on COPD.
Lactobacillus plantarum mitigates sexual-reproductive deficits by modulating insulin receptor expression in the hypothalamic-pituitary-testicular axis of hyperinsulinemic mice
Authors: Edem Edem Ekpenyong , Nathaniel Blessing Uyo , Nebo Kate Eberechukwu , Obisesan Abiola Oluwatosin , Olabiyi Ayodeji Augustine , Akinluyi Elizabeth Toyin , Ishola Azeez Olakunle 
Published: May 2021

Abstract

Objectives
Hyperinsulinemia increases the risk factor of diabetes and infertility at a manifold. Lactobacillus plantarum has several medical significances with limited reports. Hence, this study assessed the effect of L. plantarum on sexual-reproductive functions and distribution of insulin receptors in the hypothalamic-pituitary-testicular axis of hyperinsulinemic mice.

Methods
Forty male adult mice were divided into five groups as follows: control, high-fat diet (HFD) + streptozotocin (STZ), therapeutic, co-administration group type 1 (CO-AD) and probiotics. They were either simultaneously exposed to an HFD and L. plantarum treatment for 28 days with a dose of STZ injection to induce hyperinsulinemia on day 28 or treated with L. plantarum for 14 days, and following induction of hyperinsulinemia. Mice were subjected to a sexual behavioural test and thereafter sacrificed under euthanasia condition. Blood, brain and testes were collected for biochemical and immunohistochemical assays.

Results
Treatment with L. plantarum ameliorated reproductive hormones activity disruption, sexual behavioural defects, antioxidant imbalance, insulin dysregulation and lipid metabolism dysfunction following exposure to HFD + STZ when compared to the hyperinsulinemic untreated mice.

Conclusions
Taken together, data from this study reveal that L. plantarum abrogated hyperinsulinemia-induced male sexual and reproductive deficits by modulating antioxidant status, lipid metabolism and insulin signalling in the hypothalamic-pituitary-testicular axis of mice.
Evaluation of measurement uncertainty in a static tensile test
Authors: Graba Marcin 
Published: May 2021

Abstract
This article presents a scheme of the procedure for assessing the measurement uncertainty of material constants determined in the static tensile test. The key analysis was preceded by a discussion of the concept of uncertainty of measurement, equated with absolute error, the concept of relative error and methods of assessment of these errors, depending on the type of mutual dependence of the analyzed quantity and the measured quantities. The next step in this article shows examples of stress–strain curves, which were used to calculate errors, as well as specific material constants. By importing the spreadsheets of the Mathcad package, which was used in the analysis, the procedure for assessing the measurement uncertainty was specified.
Predictors of safe road-crossing behavior among female high school students of Shahr-e Kord: an application of the theory of planned behavior
Authors: Rashidi Fatemeh , Tavassoli Elahe , Babaei Heydarabadi Akbar 
Published: May 2021

Abstract

Objectives
Traffic accidents in pedestrians is one of the most important causes of death. Understanding the status quo and identification of effective factors are necessary for the management and planning of efficient training interventions in the prevention of traffic accidents for pedestrians. Hence, the present study aimed to determine the predictors of safe road-crossing behavior among female high school students of Shahr-e Kord.

Methods
The present research was a descriptive-analytical study which was conducted on 347 female high school students of Shahr-e Kord in the academic year 2016–2017. The participants were selected using random sampling method and the required data were collected through a standard questionnaire based on the theory of planned behavior. The obtained data were statistically analyzed using Pearson correlation test and regression analysis.

Results
The mean score of participants on the adoption of safe road-crossing behavior was equal to 57.06 ± 14.74. Among the independent variables of this study, the lowest and the highest scores were related to behavioral intention and outcome expectancy, respectively. The results of multiple regression test showed that behavioral beliefs, outcome expectancy, compliance motivation and behavioral intention are predictors of the adoption of safe road-crossing behavior. In total, these constructs were able to predict 25.8% of behavioral changes.

Conclusions
Based on the study findings, the theory of planned behavior can be considered an appropriate framework for designing training interventions in order to improve students’ road-crossing behavior.
Fixed point to fixed circle and activation function in partial metric space
Authors: Tomar Anita , Joshi Meena , Padaliya S. K. 
Published: May 2021

Abstract
We familiarize a notion of a fixed circle in a partial metric space, which is not necessarily the same as a circle in a Euclidean space. Next, we establish novel fixed circle theorems and verify these by illustrative examples with geometric interpretation to demonstrate the authenticity of the postulates. Also, we study the geometric properties of the set of non-unique fixed points of a discontinuous self-map in reference to fixed circle problems and responded to an open problem regarding the existence of a maximum number of points for which there exist circles.
This paper is concluded by giving an application to activation function to exhibit the feasibility of results, thereby providing a better insight into the analogous explorations.
On a Different way of Understanding the Edge-Effect for the Inference of ARMA-type Processes (in
Z
d

${\mathbb{Z}}^{d}$

)
Authors: Dimitriou-Fakalou Chrysoula 
Published: May 2021

Abstract
The edge-effect concerning the standard estimators’ bias for the parameters of multi-indexed ARMA-type series is a common hurdle; it is investigated whether an alternative ARMA parameterization might release any unwelcome complication. The theoretical blocks, of when the factorized model is free of the edge-effect, are provided and simulation results are used to reinforce the same views. Estimation or other perspectives are discussed in a conclusion.
The crystal structure of catena-poly[bis(µ2-1,2-bis((1H-imidazol-1-yl)methyl)benzene- κ2
N:N′)-bis(nitrato-κO)copper(II)], C28H28N10O6Cu
Authors: Chen Hai‐Lin , Lan Jian‐Jing , Qin Yue , Yao Dong‐Mei , Wang Yan‐Ping , Li Meng‐Xi , Tan Chuang 
Published: May 2021

Abstract
C28H28N10O6Cu, triclinic,

P

1
‾

$P\bar{1}$

(no. 2), a = 8.6869(7) Å, b = 9.0094(6) Å, c = 9.5839(8) Å, α = 74.288(7)°, β = 87.672(9)°, γ = 76.110(7)°, V = 700.69(11) Å3, Z = 1, R

gt
(F) = 0.0492, wR

ref
(F
2) = 0.0979, T = 293(2) K.
Semiotic hybridization in Persian poetry and Iranian music
Authors: Sedaghat Amir 
Published: May 2021

AbstractThis article demonstrates how Iranian classical music and Persian medieval poetry, taken as separate semiotic systems, form together, in certain contexts, a single hybrid semiotic system with overlapping structural features and shared aesthetic principles. Hjelmslev’s description of connotative semiotic systems serves as a theoretical framework to show the modalities of this hybridization. This phenomenon can be observed through comparative analysis of the interdependence of poetry and music in the Persianate World from a semiotic point of view. On the one hand, the quantitative (chronemic) meter of the Persian classical versification, called‘aruz, as well as its extraordinarily heavy use of rhyme display a formal structure that evokes that of a musical phrase. On the other hand, the dependence of the structure of the Iranian musical system upon the rhythmic structure of classical poetry suggests a unique character of which few examples exist. This interdependence manifests itself particularly in the mystic (Sufi) poetry of the medieval period, specifically in the work of such renowned poets as Rumi, Sa’di Shirāzi, and Hāfez, who are among the best-known in the West. Examples of their lyric works are examined here to demonstrate occurrences of the collusion between the two semiotic systems.
miR-380-5p facilitates NRF2 and attenuates cerebral ischemia/reperfusion injury-induced neuronal cell death by directly targeting BACH1
Authors: Wang Yibiao , Xu Min 
Published: May 2021

Abstract

Background
This study aimed to explore the role of miR-380-5p in cerebral ischemia/reperfusion (CIR) injury-induced neuronal cell death and the potential signaling pathway involved.

Methodology
Human neuroblastoma cell line SH-SY5Y cells were used in this study. Oxygen and glucose deprivation/reperfusion (OGD/R) model was used to mimic ischemia/reperfusion injury. CCK-8 assay and flow cytometry were used to examine cell survival. Quantitative real time PCR (RT-qPCR) assay and Western blotting were used to measure the change of RNA and protein expression, respectively. TargetScan and Luciferase assay was used to confirm the target of miR-380-5p. Malondialdehyde (MDA) superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) were measured using commercial kits.

Results
miR-380-5p was downregulated in SH-SY5Y cells after OGD/R. Cell viability was increased by miR-380-5p, while cell apoptosis was reduced by miR-380-5p mimics. MDA was reduced by miR-380-5p mimics, while SOD and GSHPx were increased by miR-380-5p. Results of TargetScan and luciferase assay have showed that BACH1 is the direct target of miR-380-5p. Expression of NRF2 was upregulated after OGD/R, but was not affected by miR-380-5p. mRNA expression of HO-1 and NQO1 and ARE activity were increased by miR-380-5p. Overexpression of BACH1 reversed the antioxidant and neuroprotective effects of miR-380-5p.

Conclusion
miR-380-5p inhibited cell death induced by CIR injury through target BACH1 which also facilitated the activation of NRF2, indicating the antioxidant and neuroprotective effects of miR-380-5p.
Agential Materialism and the Feminist Paradigm. A Posthumanist Approach
Authors: Fernández-Santiago Miriam 
Published: May 2021

Much has been argued within the fertile critical field of feminism in the second half of the twentieth century. With the advantage of distance from the twenty-first century, we can now gain a certain perspective on the general context of production and reception of feminist criticism as it becomes embodied in new myths that subvert the old phallogocentric ones. My approach intends to start a dialogue between such embodiments (mainly in the work of Cixous, Hayles, de Beauvoir, and Haraway) and Karen Barad’s agential materialism, using her critical construct of “phenomenon” as an instrument to understand the feminist paradigm in the post-human context and proposing accountable diffractive intra-action as an alternative to naturalized constructs.
Pendampingan Hukum Penyalahgunaan Media Sosial di SMAN 2 Kota Serang
Authors: Setiadi Wicipto , Harefa Beniharmoni , Suyanto Heru , Indrirarosa Martina 
Published: May 2021

The development of information and technology, has a positive impact on human life, but on the other, it will have a negative impact. The misuse of social media, especially in the school, is an important thing to pay attention to. This paper aims to provide understanding and legal assistance in order to avoid misuse of social media. The first step taken was to provide socialization and enlightenment to the students and the school, especially SMAN 2 Kota Serang about the dangers of misuse of social media. Understanding and enlightening students about the dangers of misuse of social media is an effort to prevent the occurrence of misuse of social media, especially in the school. The results and impact of the implementation of program can be seen in the understanding of students and schools regarding the dangers of misuse of social media. Keywords: legal protection, UU ITE, studentAbstrak:Perkembangan informasi dan teknologi disatu sisi memberikan dampak positif bagi kehidupan manusia, namun disisi lain akan memberikan dampak negatif. Penyalahgunaan media sosial khususnya dilingkungan sekolah menjadi hal penting untuk diperhatikan. Tulisan ini bertujuan untuk memberikan pemahaman dan pendampingan hukum guna menghindari penyalahgunaan media sosial. Langkah pertama yang dilakukan adalah memberikan sosialisasi dan pencerahan kepada para siswa dan pihak sekolah khususnya SMAN 2 Kota Serang akan bahaya penyalahgunaan media sosial. Pemahaman dan pencerahan kepada para siswa akan bahaya penyalahgunaan media sosial menjadi upaya pencegahan (preventif) terjadinya penyalahgunaan media sosial khususnya di lingkungan sekolah. Hasil dan dampak pelaksanaan kegiatan terlihat pada pemahaman siswa dan pihak sekolah pada bahaya penyalahgunaan media sosial. Kata kunci: perlindungan hukum, UU ITE, siswa
Effect of selenium enriched wheat substrate on the nutritional and antioxidant properties of Pleurotus spp.
Authors: Sravani A. , Sharma S. , Kalia A. 
Published: May 2021

AbstractThe study demonstrated that cultivation of Pleurotus ostreatus var. florida, Pleurotus eryngii, Pleurotus cornucopiae and Pleurotus djamor on selenium enriched substrate did not significantly affect biological efficiency (%), but total soluble protein content, total phenolic content, flavonoid content and free radical scavenging activity (%) were found to be significantly improved in Se enriched fruit bodies as compared to the control. Elemental analysis of the Se biofortified Pleurotus mushrooms through SEM-EDS showed signals characteristic for selenium on surface of P. ostreatus. var. florida and P. djamor confirming that selenium was incorporated into the cell wall of these fruiting bodies. The Se content was found to be 22.34 μg g−1 dw in Se enriched wheat straw and 0.059 μg g−1 dw in respective non-enriched wheat straw. Se contents of Se-enriched fruit bodies were found to be higher compared to non-enriched Pleurotus spp. FT-IR spectra of proteins from Pleurotus spp. indicated an increase in the flexibility, unfolding, hydrophilicity of the proteins upon Se supplementation.
Acute Hematogenous Osteomyelitis of the Rib in 14 Years Old Child: Clinical Case
Authors: Gavrilyuk Vasily P. , Donskaya Elena V. , Statina Maria I. , Severinov D. A. , Dovbnya Margarita V. 
Published: May 2021

Background.Rib osteomyelitis is extremely rare in childhood. This localization of purulent focus represents only 1% of all osteomyelitis cases. The typical manifestations of ribs osteomyelitis are fever, chest or back pain. However, these clinical signs are not always present, and the disease can manifest in other way.Clinical Case Description. Mother with 14 years old child K. have applied to the regional children's hospital admission department. The child had complains of right upper quadrant abdominal pain and in right part of the chest, difficulty in breathing. The disease began 2 days before admission with fatigue, weakness, and pyretic fever (39 °C). Complaints remained over time. The patient was hospitalized with the diagnosis: “Chest impact injury with severe pain syndrome? Right lung contusion?". The ultrasound examination of pleural cavities and the right anterior chest surface has revealed osteomyelitic phlegmon in VII intercostal space on the 3rd day of hospitalization. It was lanced and drained under general anesthesia, about 7 ml of liquid pus were obtained. The child received treatment according to clinical guidelines for the management of patients with such nosology. The final diagnosis was: «Acute hematogenous osteomyelitis of the VII rib, local form. Osteomyelitic phlegmon of VII intercostal space. Right pneumonitis. Bilateral mild hydrothorax». The boy was discharged on the 10th day since surgery in satisfactory condition.Conclusion.The described clinical case is interesting for pediatric surgeons, traumatologists, infectious disease specialist. Particular attention should be paid to the clinical features of the disease and anamnestic information in such unclear clinical cases. It will allow to exclude traumatic injuries and assume the local inflammatory process.