bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of Doppler-Based Resistive Index and Semiquantitative Renal Perfusion in Predicting Persistent Acute Kidney Injury According to Operator Experience: Post Hoc Analysis of a Prospective Multicenter Study*
Authors: Saade Anastasia , Bourmaud Aurelie , Schnell David , Darmon Michael ,   for the R2D2 Study Group
Published: October 2021

OBJECTIVES:
The Doppler-based resistive index and semiquantitative evaluation of renal perfusion using color Doppler failed to discriminate renal recovery patterns in a recent study. The influence of operator experience on resistive index and semiquantitative evaluation of renal perfusion performances is however unknown. This study aimed at evaluating the performance of resistive index and semiquantitative evaluation of renal perfusion according to the operator experience to predict short-term renal prognosis in critically ill patients.

DESIGN:
Preplanned ancillary analysis of a prospective multicenter cohort study.

SETTING:
Seven ICUs.

PATIENTS:
Unselected ICU patients.

INTERVENTION:
Renal Doppler was performed at admission to the ICU. The diagnostic performance of resistive index and semiquantitative evaluation of renal perfusion to predict persistent acute kidney injury at day 3 was evaluated.

MAIN RESULTS:
Overall, 371 patients were included, of whom 351 could be assessed for short-term renal recovery. Two thirds of the included patients had acute kidney injury (n = 233; 66.3%), of whom 136 had persistent acute kidney injury (58.4%). Overall performance in discriminating persistent acute kidney injury was however null with an area under the receiver operating characteristic curve less than 0.6 for both resistive index and semiquantitative evaluation of renal perfusion, and no difference across operator experience. A multivariate analysis using logistic regression with the center as a random effect adjusted on the operator experience showed no association between resistive index (odds ratio, 0.02 per international units (95% CI, 0.00–18.60 international units]) or semiquantitative evaluation of renal perfusion (odds ratio, 0.96 per international units [95% CI, 0.43–2.11 international units]) and persistent acute kidney injury. Similar results were obtained within subgroups of expert and nonexpert operators.

CONCLUSIONS:
Doppler-based measurements performed by an expert or a nonexpert operator did not discriminate renal recovery patterns and neither modified the risk stratification of acute kidney injury persistence.
The Smile Index: Part 3. A Simple, Prognostic Severity Scale for Unilateral Cleft Palate
Authors: Yao Caroline A. , Vartanian Emma D. , Nagengast Eric , McCullough Meghan , Auslander Allyn , Magee William P. 
Published: October 2021

Background:
Unilateral cleft palates have a large spectrum of variability. Key morphologic factors such as cleft width and palatal length are not represented in current classification systems. Palate length and velopharyngeal port size are clinically linked to speech outcomes, as the soft palate must close the posterior pharynx for proper phonation. This study investigates the relationship between objective preoperative measures and postoperative velopharyngeal port size, to define a reproducible severity scale.

Methods:
Surgical data were prospectively collected from unilateral cleft palate patients in Morocco, Bolivia, Vietnam, and Madagascar. Key measurements were cleft width and palate width at the hard–soft palate junction, alveolar cleft width, vertical alveolar discrepancy, velopharyngeal port size. Cleft width ratio (CWR) was defined as the width of the cleft at the hard–soft junction, divided by the palate width.

Results:
Seventy-six patients were evaluated. Thirty-one had complete clefts and average age at surgical repair was 2.9 years. Mean CWR was 0.50 ± 0.12. Palate length was increased by an average of 2.2 mm (11%) after palatoplasty. Multivariate analysis determined greater CWR and larger preoperative velopharyngeal ports were significantly correlated with a smaller percent change in palate length after palatoplasty (P < 0.01).

Conclusions:
A wider palatal cleft decreases the surgeon’s ability to decrease velopharyngeal port size through palatoplasty. Given the ease of measurement even in low-resource settings, CWR may be a valuable tool for setting expectations for speech results, modifying surgical technique, and correlating future speech outcomes in evidence-based cleft care.
Scarless Total Breast Reconstruction with a Fat-augmented Latissimus Dorsi Flap
Authors: Maitani Kosuke , Tomita Koichi , Taminato Mifue , Kubo Tateki 
Published: October 2021

Summary:
Total breast reconstruction with a fat-augmented latissimus dorsi flap (F-LDF) is a breakthrough approach that surmounts the shortcomings of the latissimus dorsi flap (LDF), such as volume insufficiency. Unlike the abdominal flap, the LDF can be harvested as a sole muscle flap without a skin paddle. This makes it possible to perform breast reconstruction with no donor-site scar when breast skin replacement is not required (eg, nipple-sparing mastectomy, two-stage reconstruction using a tissue expander). Here we describe a new approach for total breast reconstruction, namely scarless F-LDF reconstruction. First, the dorsal and ventral planes of the LDF are widely dissected through an inferolateral incision with monopolar electrocautery. The origin of the muscle is then separated using an energy-based device inserted through a stab incision, and immediate fat grafting is performed concurrently to the LDF and pectoralis major muscle. This new method was used in five cases, with a mean specimen weight of 285 g (range, 181–420), mean flap weight of 174 g (125–230), mean total fat graft volume of 214 ml (126–335), and mean duration of reconstruction surgery of 213 minutes (161–260). In all cases, sufficient volume was obtained postoperatively with satisfactory esthetic results. In addition to avoiding a donor-site scar, this method could reduce postoperative pain and donor-site seroma. The scarless F-LDF can be used for total breast reconstruction in certain populations, especially in cases requiring no skin replacement and for small- to medium-sized breasts.
Proprioceptive Neuromuscular Facilitation Improves Symptoms Among Older Adults With Knee Osteoarthritis During Stair Ascending
Authors: Shen Peixin , Li Li , Song Qipeng , Sun Wei , Zhang Cui , Fong Daniel T.P. , Mao Dewei 
Published: October 2021

Objective
This study aimed to investigate the effects of a 6-wk proprioceptive neuromuscular facilitation stretching on pain, proprioception, joint range of motion, and joint moments during stair ascending among older adults with knee osteoarthritis.

Design
This study is a randomized, controlled, and assessor-blinded trial. Thirty-six older adults with knee osteoarthritis were randomly assigned to the proprioceptive neuromuscular facilitation and the control groups. They received proprioceptive neuromuscular facilitation stretching and health lecture series, respectively, for 6 wks. Final data analysis included 14 participants of the proprioceptive neuromuscular facilitation group and 13 of the control group. Pain score, joint proprioception, range of motion, and joint moments during stair ascending were measured before and after the stretching. Two-way (group by time) analysis of variance with repeated measures was used to evaluate stretching effects.

Results
Significant interactions were detected in pain score, joint proprioception, external knee adduction moment, and external knee extension moment. Compared with week 0, the pain score, joint proprioception threshold, and external knee adduction moment decreased, whereas the external knee extension moment increased among older adults in the proprioceptive neuromuscular facilitation group at week 7.

Conclusions
Proprioceptive neuromuscular facilitation could be recommended as one of the clinical treatments for knee osteoarthritis to relieve pain, improve proprioception, and balance load distribution between medial and lateral compartments at the knee.
The 3-T Model of Informed Consent for Nonstandard Risk Donors: A Proposal for Transplant Clinical Practice
Authors: Grossi Alessandra Agnese , Nicoli Federico , De Feo Tullia Maria , Cardillo Massimo , Biffa Gabriella , Pegoraro Renzo , Petrini Carlo , Torelli Rosanna , Puoti Francesca , Rossini Giuseppe , Piccolo Giuseppe , Vesconi Sergio , Minetti Enrico , Pozzo Barbara , Vanacore Giuseppe , Paredes David , Grossi Paolo Antonio , Picozzi Mario 
Published: October 2021

Background.
The risk of disease transmission from nonstandard risk donors (NSRDs) is low, and outcomes are similar or better relative to transplants performed with standard criteria donors. However, NSRDs have posed new ethical challenges to the informed consent (IC) process. Based on the shared decision-making model, coinciding with the 3 main timings of the IC process ([1] pretransplant assessments and waiting list registration, [2] time on the waiting list, and [3] time of the organ offer), we put forward a model (3-T Model) to summarize the knowledge on IC for NSRDs and to deliver conceptual and practical support to transplant providers on this emergent issue.

Methods.
We searched PubMed and analyzed data from our area to provide evidence and ethical arguments to promote standardization of the timing of patient information, degree of patient participation, and disclosure of donor risk factors throughout the 3 stages of the time continuum leading to the potential acceptance of NSRDs.

Results.
Each of the 3 timings carries special ethical significance and entails well-defined duties for transplant providers relative to patient involvement and information of the benefits and risks associated with NSRDs. Based on our framework, experience, and interpretation of the literature, we put forward a list of recommendations to combine standardization (ie, timing, content, and degree of patient participation) and individualization of IC.

Conclusions.
The 3-T Model may enable the prevention of physicians’ arbitrariness and the promotion of patient-centered care. Future studies will assess the effectiveness of the 3-T Model in transplant clinical practice.
Towards Optimum Reporting of Pulmonary Effectiveness Databases and Outcomes (TORPEDO): identifying a core dataset for asthma and COPD studies
Authors: van Boven Job FM , Lucas Sarah J , Parker Gary , Kaplan Alan , Trofor Antigona , Bonevski Billie , Kirenga Bruce J , Ryan Dermot , Pizzichini Emilio , van Ganse Eric , Huang Erick Wan-Chun , Brakema Evelyn , Gould Gillian , Kocks Janwillem , Alison Jennifer , Quint Jennifer K , Soriano Joan B , Hurst John , Siddiqi Kamran , Boydell Katherine , Miravitlles Marc , Flores-Valdez Mario Alberto , Kasteleyn Marise , FitzGerald Mark , Boeckmann Melanie , Chaiton Michael , Rodriguez Miguel Roman , Kulkarni Muralidhar , Roche Nicolas , Chavannes Niels , Papadopoulos Nikolaos G , Behrakis Panagiotis , Dennis Sarah , Bassi Shalini , Williams Siân , Maher Toby M , Siddharthan Trishul , Kamath Veena , Verhamme Katia MC 
Published: October 2021

AbstractPurposeThere remains a need for a standardized dataset for respiratory studies to accelerate data collection, improve research efficiency and aid the sharing, merging and comparison of datasets. This TORPEDO (Towards Optimum Reporting of Pulmonary Effectiveness Databases and Outcomes) project aimed to develop a checklist of optimum and minimum variables for asthma and chronic obstructive pulmonary disease (COPD) research.MethodsA 3-phase modified Delphi survey was conducted: in phase 1, an expert panel generated a list of variables, in phase 2 a Delphi panel selected the minimum variables (>66% agreement) for any design and in phase 3 they were asked to select a minimum set for specific study designs.ResultsIn phase 1 the expert panel (n=22) proposed 224 variables. In phase 2, voting by 64 participants resulted in consensus (>66% agreement) for 18 variables and partial agreement (50-66%) for 44 variables, following this, 5 technical variables (e.g. date of test) were removed. In phase 3, 34 members of the Delphi panel completed voting; consensus was reached for 13 variables for retrospective asthma studies and 34 for prospective asthma studies. For COPD, there were 16 variables for retrospective studies and 37 for prospective studies. Gender, asthma/COPD exacerbations and patient-reported outcomes were the only variables with 100% agreement for both asthma and COPD studies.ConclusionThe proposed list of minimally required variables will allow the assessment of current data sources for their utility in asthma and COPD studies, facilitate the merging of datasets, aid standardization of data collection and improve research efficiency.
Immunogenicity and reactogenicity of booster vaccinations after Ad26.COV2.S priming
Authors: Sablerolles R.S.G. , Rietdijk W.J.R. , Goorhuis A. , Postma D.F. , Visser L.G. , Geers D. , Schmitz K.S. , Garrido H.M. Garcia , Koopmans M.P.G. , Dalm V.A.S.H. , Kootstra N.A. , Huckriede A.L.W. , Lafeber M. , van Baarle D. , GeurtsvanKessel C.H. , de Vries R.D. , van der Kuy P.H.M. 
Published: October 2021

AbstractBackgroundIn face of the developing COVID-19 pandemic with a need for rapid and practical vaccination strategies, Ad26.COV2.S was approved as single shot immunization regimen. While effective against severe COVID-19, Ad26.COV2.S vaccination induces lower SARS-CoV-2-specific antibody levels compared to its mRNA-based counterparts. To support decision making on the need for booster vaccinations in Ad26.COV2.S-primed individuals, we assessed the immunogenicity and reactogenicity of homologous and heterologous booster vaccinations in Ad26.COV2.S-primed health care workers (HCWs).MethodsThe SWITCH trial is a single-(participant)-blinded, multi-center, randomized controlled trial among 434 HCWs who received a single Ad26.COV2.S vaccination. HCWs were randomized to no boost, Ad26.COV2.S boost, mRNA-1273 boost, or BNT162b2 boost. We assessed the level of SARS-CoV-2-specific binding antibodies, neutralizing antibodies against infectious virus, SARS-CoV-2-specific T-cell responses, and reactogenicity.ResultsHomologous and heterologous booster vaccinations resulted in an increase in SARS-CoV-2-specific binding antibodies, neutralizing antibodies and T-cell responses when compared to single Ad26.COV.2.S vaccination. In comparison with the homologous boost, the increase was significantly larger in heterologous regimens with the mRNA-based vaccines. mRNA-1273 boosting was most immunogenic, associated with higher reactogenicity. Only mild to moderate local and systemic reactions were observed on the first two days following booster.ConclusionsBoosting of Ad26.COV2.S-primed HCWs was well-tolerated and immunogenic. Strongest responses were detected after boosting with mRNA-based vaccines. Based on our data, efficacy on infection and transmission of boosters is expected. In addition to efficacy, decision making on boost vaccinations should include timing, target population, level of SARS CoV-2 circulation, and the global inequity in vaccine access.Trial registrationFunded by ZonMW (10430072110001);ClinicalTrials.govnumber,NCT04927936.
Who has long-COVID? A big data approach
Authors: Pfaff Emily R. , Girvin Andrew T , Bennett Tellen D. , Bhatia Abhishek , Brooks Ian M. , Deer Rachel R , Dekermanjian Jonathan P , Jolley Sarah Elizabeth , Kahn Michael G. , Kostka Kristin , McMurry Julie A , Moffitt Richard , Walden Anita , Chute Christopher G , Haendel Melissa A 
Published: October 2021

AbstractBackgroundPost-acute sequelae of SARS-CoV-2 infection (PASC), otherwise known as long-COVID, have severely impacted recovery from the pandemic for patients and society alike. This new disease is characterized by evolving, heterogeneous symptoms, making it challenging to derive an unambiguous long-COVID definition. Electronic health record (EHR) studies are a critical element of the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative, which is addressing the urgent need to understand PASC, accurately identify who has PASC, and identify treatments.MethodsUsing the National COVID Cohort Collaborative’s (N3C) EHR repository, we developed XGBoost machine learning (ML) models to identify potential long-COVID patients. We examined demographics, healthcare utilization, diagnoses, and medications for 97,995 adult COVID-19 patients. We used these features and 597 long-COVID clinic patients to train three ML models to identify potential long-COVID patients among (1) all COVID-19 patients, (2) patients hospitalized with COVID-19, and (3) patients who had COVID-19 but were not hospitalized.FindingsOur models identified potential long-COVID patients with high accuracy, achieving areas under the receiver operator characteristic curve of 0.91 (all patients), 0.90 (hospitalized); and 0.85 (non-hospitalized). Important features include rate of healthcare utilization, patient age, dyspnea, and other diagnosis and medication information available within the EHR. Applying the “all patients” model to the larger N3C cohort identified 100,263 potential long-COVID patients.InterpretationPatients flagged by our models can be interpreted as “patients likely to be referred to or seek care at a long-COVID specialty clinic,” an essential proxy for long-COVID diagnosis in the current absence of a definition. We also achieve the urgent goal of identifying potential long-COVID patients for clinical trials. As more data sources are identified, the models can be retrained and tuned based on study needs.FundingThis study was funded by NCATS and NIH through the RECOVER Initiative.
Use and impact of virtual primary care on quality and safety: the public’s perspectives during the COVID-19 pandemic
Authors: Neves Ana Luisa , van Dael Jackie , O’Brien Niki , Flott Kelsey , Ghafur Saira , Darzi Ara , Mayer Erik 
Published: October 2021

AbstractBackgroundWith the onset of COVID-19, primary care has swiftly transitioned from face-to-face to virtual care, yet it remains largely unknown how this has impacted on the quality and safety of care.AimTo evaluate patient use of virtual primary care models during COVID-19 in terms of change in uptake, perceived impact on the quality and safety of care, and willingness of future use.Design and settingAn online cross-sectional survey was administered to the public across the United Kingdom, Sweden, Italy and Germany.MethodsMcNemar tests were conducted to test pre- and post pandemic differences in uptake for each technology. One-way analysis of variance was conducted to examine patient experience ratings and perceived impacts on healthcare quality and safety across demographic characteristics.ResultsRespondents (N=6,326) reported an increased use of telephone consultations (+6.3%, P<.001), patient-initiated services (+1.5%, n=98, p<0.001), video consultations (+1.4%, P<.001), remote triage (+1.3, p<0.001), and secure messaging systems (+0.9%, P=.019). Experience rates using virtual care technologies were higher for men (2.39±0.96 vs 2.29±0.92, P<.001), those with higher literacy (2.75±1.02 vs 2.29±0.92, P<.001), and participants from Germany (2.54±0.91, P<.001). Healthcare timeliness and efficiency were the quality dimensions most often reported as being positively impacted by virtual technologies (60.2%, n=2,793 and 55.7%, n=2,401, respectively), followed by effectiveness (46.5%, n=1,802), safety (45.5%, n=1,822), patient-centredness (45.2%, n=45.2) and equity (42.9%, n=1,726). Interest in future use was highest for telephone consultations (55.9%), followed by patient-initiated digital services (56.1%), secure messaging systems (43.4%), online triage (35.1%), video consultations (37.0%), and chat consultations (30.1%), although significant variation was observed between countries and patient characteristics.ConclusionFuture work must examine the drivers and determinants of positive experiences using remote care to co-create a supportive environment that ensures equitable adoption and use across different patient groups. Comparative analysis between countries and health systems offers the opportunity for policymakers to learn from best practices internationally.
PyDesigner: A Pythonic Implementation of the DESIGNER Pipeline for Diffusion Tensor and Diffusional Kurtosis Imaging
Authors: Dhiman Siddhartha , Teves Joshua B , Thorn Kathryn E , McKinnon Emilie T , Moss Hunter G , Adisetiyo Vitria , Ades-Aron Benjamin , Veraart Jelle , Chen Jenny , Fieremans Els , Benitez Andreana , Helpern Joseph A , Jensen Jens H 
Published: October 2021

ABSTRACTPyDesigner is an open-source and containerized Python software package, adapted from the DESIGNER pipeline, for diffusion weighted magnetic resonance imaging preprocessing and tensor estimation. PyDesigner combines tools from FSL and MRtrix3 to reduce the effects of signal noise and imaging artifacts on multiple diffusion measures that can be derived from the diffusion and kurtosis tensors. This publication describes the main features of PyDesigner and highlights its ease of use across platforms, while examining its accuracy and robustness in deriving commonly used diffusion and kurtosis metrics.
Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)
Authors: Zhang Xing , Zhao Chaoyue , Cheng Chaoyuan , Li Hongyue , Yu Tao , Lawrence Kevin , Sun Jimin , Yang Zeyu , Ye Ling , Chu Hongliang , Wang Ying , Han Xiaohu , Jia Yongchao , Fan Shuozhang , Kanuka Hirotaka , Tanaka Tetsuya , Jenkins Cheryl , Gedye Kristene , Chandra Shona , Price Dana C. , Liu Qiyong , Choi Young Ki , Zhan Xiangjiang , Zhang Guogang , Zhang Zhibin , Zheng Aihua 
Published: October 2021

AbstractSevere fever with thrombocytopenia syndrome virus (SFTSV) is spreading rapidly in Asia. It is transmitted by Haemaphysalis longicornis (Asian longhorned tick, ALT), which has both parthenogenetically and sexually reproducing populations. Parthenogenetic populations were found in at least 15 provinces in China and strongly correlated with the distribution of SFTS. The distribution of SFTS cases was however poorly correlated with the distribution of populations of bisexual ALTs. Phylogeographic analysis suggested that the parthenogenetic population spread much faster than bisexual population because colonization is independent of sexual reproduction. A higher proportion of parthenogenetic ALTs were collected from migratory birds captured at an SFTS endemic area, implicating the contribution to the long-range movement of ALTs in China. The SFTSV susceptibility of parthenogenetic females was like that of bisexual females under laboratory conditions. These results suggest that parthenogenetic ALT, probably transported by migratory birds, play a major role in the rapid spread of SFTSV.Article Summary LineThe parthenogenetic population of Asian longhorned tick is broadly distributed in China and plays a major role in the long-distance spread of SFTSV and perhaps future invasion of countries outside of Asia.