bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feature-based PET/MRI radiomics in patients with brain tumors
Authors: Lohmann Philipp , Meißner Anna-Katharina , Kocher Martin , Bauer Elena K , Werner Jan-Michael , Fink Gereon R , Shah Nadim J , Langen Karl-Josef , Galldiks Norbert 
Published: January 2021

Abstract
Radiomics allows the extraction of quantitative features from medical images such as CT, MRI, or PET, thereby providing additional, potentially relevant diagnostic information for clinical decision-making. Because the computation of these features is performed highly automated on medical images acquired during routine follow-up, radiomics offers this information at low cost. Further, the radiomics features can be used alone or combined with other clinical or histomolecular parameters to generate predictive or prognostic mathematical models. These models can then be applied for various important diagnostic indications in neuro-oncology, for example, to noninvasively predict relevant biomarkers in glioma patients, to differentiate between treatment-related changes and local brain tumor relapse, or to predict treatment response. In recent years, amino acid PET has become an important diagnostic tool in patients with brain tumors. Therefore, the number of studies in patients with brain tumors investigating the potential of PET radiomics or combined PET/MRI radiomics is steadily increasing. This review summarizes current research regarding feature-based PET as well as combined PET/MRI radiomics in neuro-oncology.
Multiple HC3N line observations towards 19 Galactic massive star-forming regions
Authors: Feng Huanxue , Wang Junzhi , Li Shanghuo , Shi Yong , Zhu Fengyao , Kong Minzhi , Gao Ripeng , Li Fei 
Published: January 2021

Abstract
We performed observations of the HC3N (24–23, 17–16, 11–10, 8–7) lines towards a sample consisting of 19 Galactic massive star-forming regions with the Arizona Radio Observatory 12 m and Caltech Submillimeter Observatory 10.4 m telescopes. HC3N (24–23, 17–16, 11–10, 8–7) lines were detected in sources except for W 44, where only HC3N (17–16, 11–10) were detected. Twelve of the nineteen sources showed probable line wing features. The excitation temperatures were estimated from the line ratio of HC3N (24–23) to HC3N (17–16) for 18 sources and are in the range 23– 57 K. The line widths of higher-J transitions are larger than lower-J ones for most sources. This indicates that the inner dense warm regions have more violent turbulence or other motions (such as rotation) than outer regions in these sources. A possible cutoff tendency was found around LIR ∼ 106 L⊙ in the relation between LIR and full width at half maximum line widths.
A Reappraisal of Peridotite Solidus Phase Equilibria from 6 to 14 GPa in the System CaO–MgO–Al2O3–SiO2
Authors: Keshav Shantanu , Gudfinnsson Gudmundur H 
Published: January 2021

AbstractExperimentally determined isobaric invariant melting phase relations from 6 to 14 GPa in the system CaO–MgO–Al2O3–SiO2 (CMAS), involving the crystalline phases forsterite + orthopyroxene + clinopyroxene + garnet and liquid, are reported. Experiments were conducted using a multianvil device with stepped lanthanum chromite heaters in the pressure cells. At a fixed pressure, the five-phase assemblage identified above can exist only at a single temperature. As such, these isobaric invariant points correspond to the solidus of model garnet peridotite in this part of the composition space in the studied system, as is the case at lower pressures in some previous studies. The solidus of model peridotite is univariant in pressure–temperature space, has a positive Clapeyron slope, and the isobaric invariant solidus temperatures, at 6, 8, 10, 12, and 14 GPa, are 1965 °C, 2090 °C, 2200 °C, 2280 °C, and 2320 °C, respectively. Over the investigated pressure range, orthopyroxene is in reaction relation with the liquid, with the fusion reaction taking the form forsterite + clinopyroxene + garnet = orthopyroxene + liquid. The compositions of liquids reported here do not seem to depend on orthopyroxene being present in the experiments. Compositionally, liquids here are fairly magnesian and siliceous, and have lower alumina and lime concentrations than at lower pressures with the identical crystalline phase assemblage in the system CMAS. In contrast to some previous studies, in this study, there is no evidence of maximum and minimum normative forsterite concentration of the isobaric invariant liquid at around 8 and 12 GPa, respectively, nor of a substantial curvature in the track of liquid compositions, when such liquids coexist with the above-mentioned four-phase crystalline phase assemblage. Instead, here, with increasing pressure from 6 to 14 GPa, liquids at the isobaric invariant points (defining the univariant solidus) become progressively (quasi-linearly) enstatite-normative. This experimental observation on liquid compositions from the present study might be important for future work aimed at investigating the chemistry of liquids derived from partial fusion of anhydrous peridotite at pressures, and corresponding depths in Earth, greater than investigated here.
Gene dosage compensation of rRNA transcript levels inArabidopsis thalianalines with reduced ribosomal gene copy number
Authors: Lopez Francesca B , Fort Antoine , Tadini Luca , Probst Aline V , McHale Marcus , Friel James , Ryder Peter , Pontvianne Fr�d�ric , Pesaresi Paolo , Sulpice Ronan , McKeown Peter , Brychkova Galina , Spillane Charles 
Published: January 2021

AbstractThe 45S rRNA genes (rDNA) are among the largest repetitive elements in eukaryotic genomes. rDNA consists of tandem arrays of rRNA genes, many of which are transcriptionally silenced. Silent rDNA repeats may act as ‘back-up’ copies for ribosome biogenesis and have nuclear organization roles. Through Cas9-mediated genome editing in the Arabidopsis thaliana female gametophyte, we reduced 45S rDNA copy number (CN) to a plateau of ∼10%. Two independent lines had rDNA CNs reduced by up to 90% at the T7 generation, named low copy number (LCN) lines. Despite drastic reduction of rDNA copies, rRNA transcriptional rates, and steady-state levels remained the same as wild-type plants. Gene dosage compensation of rRNA transcript levels was associated with reduction of silencing histone marks at rDNA loci and altered Nucleolar Organiser Region 2 organization. Although overall genome integrity of LCN lines appears unaffected, a chromosome segmental duplication occurred in one of the lines. Transcriptome analysis of LCN seedlings identified several shared dysregulated genes and pathways in both independent lines. Cas9 genome editing of rRNA repeats to generate LCN lines provides a powerful technique to elucidate rDNA dosage compensation mechanisms and impacts of low rDNA CN on genome stability, development, and cellular processes.
An undiscovered facet of hydraulic redistribution driven by evaporation—a study from aPopulus tomentosaplantation
Authors: Liu Yang , Nadezhdina Nadezhda , Di Nan , Ma Xu , Liu Jinqiang , Zou Songyan , Xi Benye , Clothier Brent 
Published: January 2021

AbstractMaintaining the activity and function of the shallow root system of plants is essential for withstanding drought stress, but the associated mechanism is poorly understood. By investigating sap flow in 14 lateral roots (LRs) randomly selected from trees of a Chinese white poplar (Populus tomentosa) plantation receiving three levels of irrigation, an unknown root water transport mode of simultaneous daytime bi-directional water flow was discovered. This mode existed in five LRs confined to the surface soil without attached sinker roots. In the longer term, the bi-directional water flow was correlated with the soil water content. However, within the day, it was associated with transpiration. Our data demonstrated that bi-directional root sap flow occurred during the day, and was driven by evaporative demand, further suggesting the existence of circumferential water movement in the LR xylem. We named this phenomenon evaporation-driven hydraulic redistribution (EDHR). A soil-root water transport model was proposed to encapsulate this water movement mode. EDHR may be a crucial drought-tolerance mechanism that allows plants to maintain shallow root survival and activity by promoting root water recharge under extremely dry conditions.
Relationship Between Motor Skills and Language Abilities in Children With Autism Spectrum Disorder
Authors: Wu Yen-Tzu , Tsao Chih-Hsuan , Huang Hsiao-Ching , Yang Tian-Ai , Li Yao-Jen 
Published: January 2021

AbstractObjectivesFew studies have examined the relationship between language abilities and specific motor skills in toddlers with autism spectrum disorder (ASD). The aim of this study was to compare the relationship of receptive language (RL) and expressive language (EL) abilities with motor functioning in toddlers with ASD aged 24 to 36 months and their peers with typical development (TD). Furthermore, the study compared multidimensional motor functioning in toddlers with ASD with delayed RL and EL development and toddlers with ASD and typical RL and EL development. The predictive powers of the motor skills were examined for the group with delayed RL and EL development.MethodsThe language abilities of 38 toddlers with ASD and 38 age-matched toddlers with TD were evaluated using the Receptive and Expressive Language Subscales of the Mullen Scale of Early Learning, and their motor skills were assessed using the Peabody Developmental Motor Scales, Second Edition.ResultsSignificant correlations between language ability and motor functioning were observed in the ASD and TD groups. The ASD group with delayed RL and EL development had lower scores for multidimensional motor functioning than the ASD group with typical RL and EL development and the TD group. Moreover, the risks of delayed EL and RL development could be predicted by the lower motor scores in toddlers with ASD.ConclusionsThe positive correlation between language abilities and motor functioning in toddlers with ASD indicated potential connections between the early onsets of motor and speech-language impairments in these toddlers.ImpactThe results may have implications for the development of motor-based interventions targeting language development in young children with ASD.
Outpatient Physical Therapy Use Following Tibial Fractures: A Retrospective Commercial Claims Analysis
Authors: McLaughlin Kevin H , Reider Lisa M , Castillo Renan C , Ficke James R , Levy Joseph F 
Published: January 2021

Abstract

Objective
The purpose of this study was to characterize outpatient physical therapy (OPT) use following tibial fractures and examine the variability of OPT attendance, time of initiation, number of visits, and length of care by patient, injury, and treatment factors. In the absence of clinical guidelines, results will guide future efforts to optimize OPT following tibial fractures.

Methods
This study used 2016 to 2017 claims from the IBM MarketScan Commercial Claims Research Database. The cohort included 9079 patients with International Classification of Diseases: Tenth Revision (ICD-10) diagnosis codes for tibial fractures. Use in the year following initial fracture management was determined using Current Procedural Terminology codes. Differences in use were examined using χ2 tests, t tests, and Kruskal-Wallace tests.

Results
Sixty-seven percent of patients received OPT the year following fracture. OPT attendance was higher in female patients, in patients with 1 or no major comorbidity, and in the western United States. Attendance was higher in patients with upper tibial fractures, moderate-severity injuries, and treatment with external fixation and in patients discharged to an inpatient rehabilitation facility. Patients started OPT on average [SD] 50 [52.6] days after fracture and attended 18 [16.1] visits over the course of 101 [86.4] days. The timing of OPT, the number of visits attended, and the length of OPT care varied by patient, injury, and treatment-level factors.

Conclusions
One-third of insured patients do not receive OPT following tibial fracture. The timing of OPT initiation, the length of OPT care, and the number of visits attended by patients with tibial fractures were highly variable. Further research is needed to standardize referral and prescription practices for OPT following tibial fractures.

Impact
OPT use varies based on patient, injury, and treatment-level factors following tibial fractures. Results from this study can be used to inform future efforts to optimize rehabilitation care for patients with tibial fractures.
Content analysis of Netflix and Amazon Prime Instant Video original films in the UK for alcohol, tobacco and junk food imagery
Authors: Alfayad Khaldoon , Murray Rachael L , Britton John , Barker Alexander B 
Published: January 2021

Abstract

Background
Exposure to alcohol, tobacco and high fat, sugar and salt (HFSS) food imagery is a significant risk factor for the uptake and regular use of these products in young people, and imagery are more frequently portrayed in video-on-demand (VOD) than in terrestrial television programmes. This study compared alcohol, tobacco and HFSS imagery in original films on Amazon Prime Instant Video and Netflix.

Methods
Content analysis of 11 original films released by Amazon Prime and Netflix in 2017 using 5-minute interval coding of alcohol, tobacco and HFSS content. Proportions of intervals containing alcohol, tobacco and HFSS imagery were compared between services using the chi-square test.

Results
Alcohol content appeared in 200 (41.7%) out of the total of 479 intervals coded, whereas tobacco and HFSS appeared in 129 (26.9%) and 169 (35.24%), respectively. Proportions were similar between Amazon Prime Instant Video and Netflix original films and were unrelated to film age classification.

Conclusions
Alcohol, tobacco and HFSS content likely to promote consumption among young people occurs frequently in original films shown by VOD services in the UK. Further studies are needed to investigate effective regulatory frameworks for VOD services to protect viewers from harmful or unwanted contents.
Seasonal trends in photosynthesis and leaf traits in scarlet oak
Authors: Burnett Angela C , Serbin Shawn P , Lamour Julien , Anderson Jeremiah , Davidson Kenneth J , Yang Dedi , Rogers Alistair 
Published: January 2021

Abstract
Understanding seasonal variation in photosynthesis is important for understanding and modeling plant productivity. Here, we used shotgun sampling to examine physiological, structural and spectral leaf traits of upper canopy, sun-exposed leaves in Quercus coccinea Münchh (scarlet oak) across the growing season in order to understand seasonal trends, explore the mechanisms underpinning physiological change and investigate the impact of extrapolating measurements from a single date to the whole season. We tested the hypothesis that photosynthetic rates and capacities would peak at the summer solstice, i.e., at the time of peak photoperiod. Contrary to expectations, our results reveal a late-season peak in both photosynthetic capacity and rate before the expected sharp decrease at the start of senescence. This late-season maximum occurred after the higher summer temperatures and vapor pressure deficit and was correlated with the recovery of leaf water content and increased stomatal conductance. We modeled photosynthesis at the top of the canopy and found that the simulated results closely tracked the maximum carboxylation capacity of Rubisco. For both photosynthetic capacity and modeled top-of-canopy photosynthesis, the maximum value was therefore not observed at the summer solstice. Rather, in each case, the measurements at and around the solstice were close to the overall seasonal mean, with values later in the season leading to deviations from the mean by up to 41 and 52%, respectively. Overall, we found that the expected Gaussian pattern of photosynthesis was not observed. We conclude that an understanding of species- and environment-specific changes in photosynthesis across the season is essential for correct estimation of seasonal photosynthetic capacity.
Development and Psychometric Evaluation of the Female Substance Abusers’ Reproductive Health Scale: Study Protocol for a Sequential Exploratory Mixed-method Study
Authors: Shamsalinia Abbas , Shafti Vida , Nikpour Maryam , Ghaffari Fatemeh 
Published: January 2021

Aims:
This study aims at the development and psychometric evaluation of the Female Substance Abusers’ Reproductive Health Scale (FSARHS).

Design, Setting and Participants:
This is the protocol of a sequential exploratory mixed-method study. The study will be conducted in an FSARHS development phase and an FSARHS psychometric evaluation phase. In the first phase, a qualitative study and a literature review will be conducted for item generation. In the qualitative study, semi-structured interviews will be held with female substance abusers. Data will be analyzed through conventional content analysis and the draft of FSARHS will be developed. In the psychometric evaluation phase, the face, content, and construct validity and reliability of FSARHS will be assessed.

Conclusions:
FSARHS can be used by reproductive health policy makers and health care providers at national and international levels in order to assess reproductive health among female substance abusers.
Is There a Relationship Between Heroin Dependence and Anemia?
Authors: Demir Bahadir , Altindag Abdurrahman 
Published: January 2021

Objective:
We aimed to examine hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean cell hemoglobin concentration, red blood cell count (RBC), platelet count (PLT), ferritin, vitamin B12, and folic acid levels in heroin addicts by comparing them with healthy controls.

Materials and Methods:
This study included a total of 325 patients with only heroin use; and 163 healthy individuals. Participants, who had hematological disorders and other chronic diseases, were excluded from the study. HGB, HCT, MCV, mean cell hemoglobin concentration, RBC, PLT, ferritin, vitamin B12, and folic acid levels were compared between groups.

Results:
The patient group comprised of 318 males and 7 females with the mean age of 26.39±6.18 years. There was no significant difference between patient and control group in terms of age, sex, body mass index and alcohol consumption. HGB, HCT, folic acid levels, and RBC were lower in the patient group than control. There was no significant correlation among HGB, HCT, RBC, PLT, and the sociodemographic characteristics of patients.

Conclusion:
The effects of heroin on the hematological parameter should be considered. Heroin effects on HGB, HTC, RBC, and folic acid may tend to decrease. Prospective, longitudinal studies, and studies involving intoxication-remission periods are needed.
How Do We Allocate Our Resources When Listening and Memorizing Speech in Noise? A Pupillometry Study
Authors: Bönitz Hanna , Lunner Thomas , Finke Mareike , Fiedler Lorenz , Lyxell Björn , Riis Søren Kamaric , Ng Elaine , Valdes Alejandro Lopez , Büchner Andreas , Wendt Dorothea 
Published: January 2021

Objectives:
Actively following a conversation can be demanding and limited cognitive resources must be allocated to the processing of speech, retaining and encoding the perceived content, and preparing an answer. The aim of the present study was to disentangle the allocation of effort into the effort required for listening (listening effort) and the effort required for retention (memory effort) by means of pupil dilation.

Design:
Twenty-five normal-hearing German speaking participants underwent a sentence final word identification and recall test, while pupillometry was conducted. The participants’ task was to listen to a sentence in four-talker babble background noise and to repeat the final word afterward. At the end of a list of sentences, they were asked to recall as many of the final words as possible. Pupil dilation was recorded during different list lengths (three sentences versus six sentences) and varying memory load (recall versus no recall). Additionally, the effect of a noise reduction algorithm on performance, listening effort, and memory effort was evaluated.

Results:
We analyzed pupil dilation both before each sentence (sentence baseline) as well as the dilation in response to each sentence relative to the sentence baseline (sentence dilation). The pupillometry data indicated a steeper increase of sentence baseline under recall compared to no recall, suggesting higher memory effort due to memory processing. This increase in sentence baseline was most prominent toward the end of the longer lists, that is, during the second half of six sentences. Without a recall task, sentence baseline declined over the course of the list. Noise reduction appeared to have a significant influence on effort allocation for listening, which was reflected in generally decreased sentence dilation.

Conclusion:
Our results showed that recording pupil dilation in a speech identification and recall task provides valuable insights beyond behavioral performance. It is a suitable tool to disentangle the allocation of effort to listening versus memorizing speech.
New strategies for the management of ocular surface disease in glaucoma patients
Authors: Voicu Laura , Salim Sarwat 
Published: January 2021

Purpose of review
Glaucoma patients commonly suffer from ocular surface disease (OSD). As treatment strategies, medications and devices for the treatment of OSD as well as glaucoma surgical approaches evolve rapidly, it is important to consider their application to these patients.

Recent findings
OSD in glaucoma patients may lead to reduced reliability of diagnostic tests, decreased medication compliance, poor surgical outcomes, and overall decreased quality of life. Chronic use of topical glaucoma medications has been linked to the development of limbal stem cell deficiency, and the role of preservatives in OSD continues to be demonstrated. Preservative free glaucoma medications as well as new anti-inflammatory agents for the treatment of OSD are now available. Omega-3 fatty acid supplementation and punctal plugs have been shown to benefit glaucoma patients with OSD. Drop burden may be reduced through the use of the new sustained-release delivery systems, selective laser trabeculoplasty, and minimally invasive glaucoma surgery.

Summary
There are multiple emerging strategies for managing OSD that may be applied to patients with glaucoma. With continued research and clinical experiences, we hope to better understand the multifaceted relationship between glaucoma and OSD and develop evidence-based algorithms for the management of these complex patients.