bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feed forensic strategy: Incorporating multivariate data analysis with high-performance liquid chromatography refractive index detector and differential scanning calorimeter for authentication of fish feed sources
Authors: Idris Mohamed Haniff Hanafy , Sani Muhamad Shirwan Abdullah , Hashim Amalia Mohd , Zaki Nor Nadiha Mohd , Manaf Yanty Noorzianna Abdul , Desa Mohd Nasir Mohd , Arshad Syariena , Yuswan Mohd Hafis , Hassan Mohd Sukri , Yusof Yus Aniza , Kamaruddin Mohd Salleh , Mustafa Shuhaimi 
Published: December 2021

Abstract
This study authenticated fish feed sources and determined lard adulteration using dataset pre-processing, principal component analysis (PCA), discriminant analysis (DA) and partial least square regression (PLSR) on 19 triacylglycerols (TAGs) and 16 thermal properties (TPs). At cumulative variability (90.625%) and Keiser-Meyer Olkin (KMO) value (0.811), the PCA identified strong factor loading variables, i.e., OLL, PLL, OOL, POL, PPL, POO, PPO, PSO, ICT and FHT in PC1 and LLLn, OOO and CT2 in PC2. These variables were significantly (p < 0.05) contributing to lard-palm-oil (L-PO) clusters: (1) POO, PPO and PPL (high loading) and OLL, PLL, OOL, ICT, POL, PSO and FHT (low loading) in 0:100 and 25:75 L-PO clusters; (2) CT2, OOO and LLLn (high loading) in 50:50 L-PO cluster; and (3) OLL, PLL, OOL, ICT, POL, PSO and FHT (high loading) and POO, PPO and PPL (low loading) in 72:25 and 100:0 L-PO clusters. Training, validation and testing datasets had 100%, 84.44% and 100% correct-classification, respectively at p < 0.0001 of Wilks' lambda and p < 0.0001 Fisher distance. The DA selected PLL, OOL, POL, PPL, PSO, ICT and FHT as the significantly authenticating biomarkers (p < 0.05). With determination coefficient (R²) (0.9693), mean square error (MSE) (38.382) and root mean square error (RMSE) (6.195), the PLSR's variable importance in the projection (VIP) identified the most influential biomarkers, i.e., PPL, POL, PPO, OOL, ICT, PLL, FHT, POO and OLL. The Z-test result (p > 0.05) indicated that the PLSR could determine the lard adulteration percentage in fish feed.
First-principles calculations of high-pressure physical properties anisotropy for magnesite
Authors: Liu Zi-Jiang , Sun Xiao-Wei , Zhang Cai-Rong , Zhang Shun-Jing , Zhang Zheng-Rong , Jin Neng-Zhi 
Published: December 2021

Abstract
The first-principles calculations based on density functional theory with projector-augmented wave are used to study the anisotropy of elastic modulus, mechanical hardness, minimum thermal conductivity, acoustic velocity and thermal expansion of magnesite(MgCO3) under deep mantle pressure. The calculation results of the phase transition pressure, equation of state, elastic constants, elastic moduli, elastic wave velocities and thermal expansion coefficient are consistent with those determined experimentally. The research results show that the elastic moduli have strong anisotropy, the mechanical hardness gradually softens with increasing pressure, the conduction velocity of heat in the [100] direction is faster than that in the [001] direction, the plane wave velocity anisotropy first increases and then gradually decreases with increasing pressure, and the shear wave velocity anisotropy increases with the increase of pressure, the thermal expansion in the [100] direction is greater than that in the [001] direction. The research results are of great significance to people's understanding of the high-pressure physical properties of carbonates in the deep mantle.
Distinct functions of genome-wide chromatin remodeling in the differentiation of T helper Type 1 and 2 cells
Authors: Zeng Wei-ping 
Published: December 2021

Abstract
T helper type 1 and 2 (Th1 and Th2) cells play critical roles in infectious, autoimmune and allergic diseases. Here we mapped genome-wide distribution of DNase I hypersensitive (DHS) sites in Th1, Th2 and their precursors naïve CD4 T cells. DHS sites were found unevenly distributed in the genomes with highest densities within 2kb of the transcription start sites (TSS). At the whole genome level, the DHS values, representing chromatin openness, but not the numbers of DHS sites showed strong positive correlation with gene expression. Th1 and Th2 differentiations were accompanied by changes of genome-wide distribution of DHS sites. The differentiated cells assumed more open chromatin structures than their precursors. During Th1 differentiation changes of DHS values could be statistically positively or negatively associated with changes of gene expression depending on the locations of the DHS sites, whereas only positive association was found during Th2 differentiation.
Machine Learning Based User Retention and Channel Allocation: 6G Aspect
Authors: Singh Pushpa , Agrawal Rajeev , Singh Krishan Kant 
Published: December 2021

Abstract
Future 6G wireless network will be focused on Artificial Intelligence (AI) based network selection, resource allocation and user satisfaction. A user has multiple options to switch one service provider to another service provider in case of network quality degradation. The new schemes/policies are required to retain their valuable users. This paper proposed supervised machine learning methods such as Decision Tree, K-Nearest Neighbor (KNN), Support Vector Machine (SVM), etc., to classify and identify the loyal user. The decision tree algorithm has been identified as the best classification technique in order to identify the type of user (loyal, normal, and recent). A threshold-based algorithm is proposed to allocate the resource, particularly to loyal users. The performance of the algorithm is measured in terms of average waiting time (AWT), and the number of particular types of user’s services dropped. Priority is given to the loyal user when only 10% network resource is available. The simulation environment is created by SimPy implemented in Python. The result of the simulation run represents that no loyal user’ services have been interrupted during communication. Loyal users achieved less AWT as 32.51s compare to the normal user and recent user.
Multidisciplinary treatment from infancy to adolescence of a patient with a unilateral cleft lip and palate: a 16-year follow-up case report
Authors: Ozturk Taner , Yagci Filiz , Yagci Ahmet 
Published: December 2021

Abstract
Cleft lip and palate (CLP) are conditions that require long-term management and review from infancy to adolescence. Surgical procedures become easier when nasoalveolar moulding (NAM) measures are applied during the neonatal period. Orthodontic treatment provided for these patients during the progressive dentition developmental periods can achieve positive aesthetic and functional results. In patients affected by a CLP, the lateral incisor in the cleft region is usually missing and multidisciplinary prosthodontic rehabilitation of the edentulous space is often required. In the present case report, positive results of NAM, coupled with orthodontic and prosthodontic treatment are presented for a CLP patient who began management during the neonatal period. In addition, a minimally invasive aesthetic restoration is presented as a solution for the prosthodontic rehabilitation of a missing lateral incisor.
A FITOTERAPIA NO CONTEXTO DA ATENÇÃO BÁSICA
Authors: Costa Josefa Waldenora da , Ferreira Karla Cristina Marques Afonso , Moutinho Nathanny Ferreira , Bezerra Thiago da Silva , Nunes Vilani Medeiros de Araújo 
Published: December 2021

Objetivo: Avaliar o uso de plantas medicinais e o nível de conhecimento sobre fitoterapia por gestores e gerentes das Unidades de Saúde da Família (USF), bem como dos profissionais das equipes da Estratégia deSaúde da Família e da comunidade assistida por essas equipes. Metodologia: Estudo descritivo com abordagem quantitativa realizadoem Parnamirim, RN. Foram entrevistados 596 usuários em seis USF, 08 gestores/gerentes dos serviços e 123 profissionais da saúde, entre julho e setembro de 2016. Resultados: Falta de coerência entre a espécie da planta citada pelos usuários e a doença tratada com as indicações encontradas na literatura. Entre os profissionais, 60,2% referem pouco conhecimento sobre fitoterapia, 91,9% dos gestores desconhece a Política Nacional de Plantas Medicinais e Fitoterápicos, embora 50,4% já tenham indicado tratamento à base de plantas medicinais. Conclusão: Verificou-se que grande desafio na consolidação do uso de Plantas edicinais e Fitoterápicos na qualificação dos profissionais.
Systemic Treatments for Adult Patients with Moderate-to-Severe Psoriasis:
Consensus Statements for the United Arab Emirates
Authors: Hammadi Anwar Al , Murrawi Muna Al , Ali Huda R. , Reda Ashraf M. , Dayem Hussein A. , Alnaqbi Jawaher , Abdelhadi Zaidoon , Hantirah Samir , Alnaeem Ayman , Marzooqi Fatima Al. , Alfalasi Amani , Albreiki Fatima , Aljefri Khadija , Ali Faiza Al 
Published: December 2021

Background:
Psoriasis is a chronic, immune-mediated disease characterized by mild localized plaques to severe plaques involving any part of the skin; it has a
pronounced effect on patients’ quality of life. In the United Arab Emirates (UAE), there are limited local guidelines for the management of patients
with psoriasis in daily clinical practice.

Objectives:
The study aimed to develop consensus statements for the evaluation and management of moderate-to-severe psoriasis in the UAE.

Methods:
To develop consensus statements, the Emirates Dermatology Society set up advisory board meetings in which local key opinion leaders (KOLs),
including dermatologists from the UAE, participated. A targeted literature review was conducted to review current international and regional
guidelines on the management of psoriasis, based on which the statements were formulated. A final consensus on each statement was reached
based on collective agreement among the KOLs.

Results :
Consensus statements were generated with the intention of supporting physicians in clinical decision-making with respect to the classification of
disease severity, treatment options including biologic and non-biologic systemic therapies, transitioning and adjusting of systemic therapies, and
monitoring and management of psoriasis in special populations.

Conclusion:
These consensus statements could provide useful, practical guidance on the diagnosis and management of patients with moderate-to-severe
psoriasis and would cater to the needs of physicians in the UAE.
Dose-Dependent Degeneration of Leydig Cells Following Kisspeptin-10 Administration: An Ultrastructural Study
Authors: Ramzan Faiqah , Qureshi Irfan Zia , Ramzan Muhammad Haris 
Published: December 2021

Background:
The discovery of kisspeptin signaling as a key regulator of gonadotropin-
releasing hormone (GnRH) secretion from the hypothalamus enhanced our understanding
of the neuroendocrine regulation of mammalian reproduction. Effects of central and peripheral administration
of kisspeptin on plasma gonadotropins, testosterone, and spermatogenesis are studied
in detail.

Objective:
The present study was conducted to check the ultrastructure of Leydig cells in prepubertal
male rats in response to the administration of a range of kisspeptin doses.

Method:
We administered a range of kisspeptin-10 doses (1 μg, 1 ηg, and 10 ρg) intraperitoneally
to prepubertal male Sprague-Dawley rats (PND 35) twice daily after every 12 hours. Control rats
were injected with physiological saline in parallel.

Results:
At the end of the treatment, plasma concentrations of testosterone were measured by competitive
binding radioimmunoassay, and small pieces of rat testicular tissue were processed for electron
microscopy to examine the ultrastructure of Leydig cells. Plasma testosterone concentration
was reduced significantly at 1ηg (P<0.05) and 1μg (P<0.01) doses as compared to control. Distinct
ultrastructural changes categorized as dilatation of cytoplasmic organelles, irregularly shaped nuclei
with nuclear membrane invaginations, reduced nuclear sizes, degeneration, and vacuolation
were observed in the kisspeptin-10 treated Leydig cells as compared to control. Quantification of
the data showed reduced Leydig cell indices and hyperplasia of the interstitial cells.

Conclusion:
It is concluded that chronic intermittent administration of kisspeptin-10 has a dose-dependent
degenerative effect on the plasma testosterone levels and Leydig cells ultrastructure in prepubertal
male rats.
H19: A Vital Long Noncoding RNA in the Treatment of Diabetes and Diabetic
Complications
Authors: Zhu Leiqi , Li Yuanyang , Xia Fangqi , Xue Mengzhen , Wang Yaqi , Jia Dengke , Gao Yan , Li Luoying , Shi Yue , Chen Silong , Xu Guangfu , Yuan Chengfu 
Published: December 2021

Background:
Increasing academic efforts have been made to explore the correlation of long noncoding
RNAs (lncRNAs) with human diseases, particularly metabolic diseases like diabetes mellitus. Taking lncRNA
H19 as an example, this review intends to reveal the functions and mechanism of lncRNA H19 in diabetes
mellitus and diabetic complications.

Methods:
The research results associated with lncRNA H19 and diabetes mellitus are collected and summarized
on PubMed.

Conclusion:
LncRNA H19 is a potential instructive marker for the treatment of diabetes mellitus and diabetic
complications.
Phage-choline Kinase Inhibitor Combination to Control Pseudomonas
aeruginosa: A Promising Combo
Authors: Khalifa Moad , Few Ling Ling , Too Wei Cun See 
Published: December 2021

Background::
Pseudomonas aeruginosa is one of the most prevalent opportunistic pathogens
in humans that has thrived and proved to be difficult to control in this “post-antibiotic era.” Antibiotic
alternatives are necessary for fighting against this resilient bacterium. Even though phages
might not be “the wonder drug” that solves everything, they still provide a viable option to combat P.
aeruginosa and curb the threat it imposes.

Main findings::
The combination of antibiotics with phages, however, poses a propitious treatment
option for P. aeruginosa. Choline kinase (ChoK) is the enzyme that synthesizes phosphorylcholine
subsequently incorporated into lipopolysaccharide located at the outer membrane of gram-negative
bacteria. Recently, inhibition of ChoKs has been proposed as a promising antibacterial strategy. Successful
docking of Hemicholinium-3, a choline kinase inhibitor, to the model structure of P. aeruginosa
ChoK also supports the use of this inhibitor or its derivatives to inhibit the growth of this microorganism.

Conclusion::
Therefore, the combination of the novel antimicrobial “choline kinase inhibitors (ChoKIs)”
with a phage cocktail or synthetic phages as a potential treatment for P. aeruginosa infection has
been proposed.
Multifaceted Effects of Intermittent Fasting on the Treatment and Prevention
of Diabetes, Cancer, Obesity or Other Chronic Diseases
Authors: Tagde Priti , Tagde Sandeep , Bhattacharya Tanima , Tagde Pooja , Akter Rokeya , Rahman Md. Habibur 
Published: December 2021

Background:
Obesity and diabetes are global epidemics resulting in a range of comorbidities.
Both have been linked to an increased risk of hormonal imbalance, cancer, and other significant
disorders, which are a concerning trend for cancer rates in the backdrop of rising obesity
and diabetes rates worldwide. Around 1 in 10 persons in the United States and Canada have serious
illnesses correlated to type 2 diabetes and early death. It is believed that the US economy alone
spends $245 billion annually due to this health burden. Lifestyle modification with intermittent
fasting protocol and proper diet helps lower blood glucose level, maintain the body mass index,
and reduce inflammation, which is the main cause of all chronic diseases.

Methods:
We searched case series and clinical trials on type 2 diabetes, insulin resistance, cancer,
thyroid, cardiovascular disease, or other inflammatory diseases in response to intermittent fasting
in the PubMed, MEDLINE, and Google Scholar databases.

Objective:
In this review, we have focused on intermittent fasting-based approaches that are becoming
more widely accepted for improving health and reducing unwanted effects in patients with
type 2 diabetes, cancer, cardiovascular disease, neurodegenerative disease, obesity, thyroid, and
hormonal imbalance; it is also contemplated whether intermittent fasting can be considered as a
non-medicinal therapeutic option for persons suffering from chronic diseases.

Conclusion:
Intermittent fasting successfully reversed diabetes, thyroid, and high blood pressure, elevated
lipid levels, and maintained the body mass index; also, studies have shown that it has been instructed
to be followed for the treatment and prevention of cancer and neurodegenerative diseases.
New Synthetic Sulfonamide Chalcone Induced Cell Cycle Arrest and Cell Death in
Colorectal Adenocarcinoma Metastatic Cells (SW-620)
Authors: Moura Andréa Felinto , de Castro Mirian Rita Carrilho , Naves Raquel Ferreira , Araújo Ana Jérsia , dos Santos Maria Claudia Luciano , Filho José Delano Barreto Marinho , Noda-Perez Caridad , Terra Martins Felipe , do O Pessoa Claudia , Filho Manoel Odorico Moraes 
Published: December 2021

Background:
New chalcones have been developed from the insertion of organic groups, among them sulfonamides,
presenting varied biological activity.

Objective:
The aim of this work was to determine the antitumor potential of a new synthetic sulfonamide chalcone
(SSC185) against a colorectal metastatic lymph node-derived colorectal cancer cell line (SW-620).

Methods:
Synthesis and characterization, including crystallography, of SSC185 were performed. SSC185 showed a
selective cytotoxic effect against colorectal cancer cell lines. Therefore, the cytotoxic effect of SSC185 against SW-
620 was further investigated. We used optical and fluorescence microscopy, flow cytometry and Western blot to determine
the antitumor effects of SSC185.

Results:
SSC185 induced cytotoxicity in SW-620 cells in a time and concentration-dependent manner. Cell cycle progression
was disrupted, with increased G2/M cell number and consequent cell death, with morphological alterations
associated with apoptosis and necrosis. Cell death was associated with the activation and cleavage of PARP, and with
reduced expression of the pro-apoptotic Bax protein and caspase 8, depending on the SSC185 concentration tested.
Expression of the necroptosis pathway proteins RIP and MLKL was also reduced. These proteins are phosphorylated
during the process of necroptosis.

Conclusion:
We suggest that the mechanism involved in the cytotoxic effect of SSC185 against SW-620 in vitro may
be related to the induction of cell cycle arrest in the G2/M phase and cell death by apoptosis or necroptosis, depending
on the concentration used.
Speech as a Biomarker for Depression
Authors: Koops Sanne , Brederoo Sanne G. , de Boer Janna N. , Nadema Femke G. , Voppel Alban E. , Sommer Iris E. 
Published: December 2021

Background:
Depression is a debilitating disorder that at present lacks a reliable biomarker
to aid in diagnosis and early detection. Recent advances in computational analytic approaches
have opened up new avenues in developing such a biomarker by taking advantage of the wealth
of information that can be extracted from a person’s speech.

Objective:
The current review provides an overview of the latest findings in the rapidly evolving
field of computational language analysis for the detection of depression. We cover a wide range of
both acoustic and content-related linguistic features, data types (i.e., spoken and written language),
and data sources (i.e., lab settings, social media, and smartphone-based). We put special focus on
the current methodological advances with regard to feature extraction and computational modeling
techniques. Furthermore, we pay attention to potential hurdles in the implementation of automatic
speech analysis.

Conclusion:
Depressive speech is characterized by several anomalies, such as lower speech rate,
less pitch variability and more self-referential speech. With current computational modeling techniques,
such features can be used to detect depression with an accuracy of up to 91%. The performance
of the models is optimized when machine learning techniques are implemented that suit the
type and amount of data. Recent studies now work towards further optimization and generalizability
of the computational language models to detect depression. Finally, privacy and ethical issues
are of paramount importance to be addressed when automatic speech analysis techniques are further
implemented in, for example, smartphones. Altogether, computational speech analysis is well
underway towards becoming an effective diagnostic aid for depression.
Examining the Concept of Liveability in Urban Neighbourhoods in Iskandar Malaysia
Authors: Wan Ismail Wan Azlina , Dempsey Nicola 
Published: December 2021

Liveability is a critical concept in urban planning and geography. It is well-used in planning policy with different geographical contexts; however, there are limitations in understanding this concept in the Malaysian context. This research examines the relationship of liveability between people and places in their daily lives in urban neighbourhoods through residents' perceptions. Quantitative data collected in 5 urban neighbourhoods in Iskandar Malaysia suggests that liveability must correspond to residents' requirements for good quality facilities and services, good neighbourhood conditions and positive community engagement.
Keywords: Liveability Dimensions; Policy Interpretation; Urban Neighbourhood; Iskandar Malaysia
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i18.3084