bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia-Inducible Factor-1α (HIF-1α) Inhibition Impairs Retinoic Acid-Induced Differentiation in SH-SY5Y Neuroblastoma Cells, Leading to Reduced Neurite Length and Diminished Gene Expression Related to Cell Differentiation
Authors: Brum Pedro Ozorio , Viola Guilherme Danielski , Saibro-Girardi Carolina , Tiefensee-Ribeiro Camila , Brum Matheus Ozorio , Gasparotto Juciano , Krolow Rachel , Moreira José Cláudio Fonseca , Gelain Daniel Pens 
Published: September 2021

AbstractNeuroblastoma is the most common extracranial solid tumour in childhood, originated from cells of the neural crest during the development of the Sympathetic Nervous System. Retinoids are vitamin-A derived differentiating agents utilised to avoid disease resurgence in high-risk neuroblastoma treatment. Several studies indicate that hypoxia—a common feature of the tumoural environment—is a key player in cell differentiation and proliferation. Hypoxia leads to the accumulation of the hypoxia-inducible factor-1α (HIF-1α). This work aims to investigate the effects of the selective inhibition of HIF-1α on the differentiation induced by retinoic acid in human neuroblastoma cells from the SH-SY5Y lineage to clarify its role in cell differentiation. Our results indicate that HIF-1α inhibition impairs RA-induced differentiation by reducing neuron-like phenotype and diminished immunolabeling and expression of differentiation markers.
Graphic Abstract

HIF1A is involved in Retinoic Acid (RA) induced differentiation in SH-SY5Y neuroblastoma cells. siRNA HIF1A gene silencing leads to a weaker response to RA, demonstrated by changes in the neuro-like phenotype and diminished expression of differentiation markers.
Trajectories of a ball moving inside a spherical cavity using first integrals of the governing nonlinear system
Authors: Náprstek Jiří , Fischer Cyril 
Published: September 2021

AbstractAnalytical study of ball vibration absorber behavior is presented in the paper. The dynamics of trajectories of a heavy ball moving without slipping inside a spherical cavity are analyzed. Following our previous work, where a similar system was investigated through various numerical simulations, research of the dynamic properties of a sphere moving in a spherical cavity was carried out by methods of analytical dynamics. The strategy of analytical investigation enabled definition of a set of special and limit cases which designate individual domains of regular trajectories. In order to avoid any mutual interaction between the domains along a particular trajectory movement, energy dissipation at the contact of the ball and the cavity has been ignored, as has any kinematic excitation due to cavity movement. A governing system was derived using the Lagrangian formalism and complemented by appropriate non-holonomic constraints of the Pfaff type. The three first integrals are defined, enabling the evaluation of trajectory types with respect to system parameters, the initial amount of total energy, the angular momentum of the ball and its initial spin velocity. The neighborhoods of the limit trajectories and their dynamic stability are assessed. Limit and transition special cases are investigated along with their individual elements. The analytical means of investigation enabled the performance of broad parametric studies. Good agreement was found when comparing the results achieved by the analytical procedures in this paper with those obtained by means of numerical simulations, as they followed from the Lagrangian approach and the Appell–Gibbs function presented in previous papers.
The Regularity Problem for Uniformly Elliptic Operators in Weighted Spaces
Authors: Chen Li , Martell José María , Prisuelos-Arribas Cruz 
Published: September 2021

AbstractThis paper studies the regularity problem for block uniformly elliptic operators in divergence form with complex bounded measurable coefficients. We consider the case where the boundary data belongs to Lebesgue spaces with weights in the Muckenhoupt classes. Our results generalize those of S. Mayboroda (and those of P. Auscher and S. Stahlhut employing the first order method) who considered the unweighted case. To obtain our main results we use the weighted Hardy space theory associated with elliptic operators recently developed by the last two named authors. One of the novel contributions of this paper is the use of an “inhomogeneous” vertical square function which is shown to be controlled by the gradient of the function to which is applied in weighted Lebesgue spaces.
Neochloris oleoabundans from nature to industry: a comprehensive review
Authors: Safi Carl , Pollio Antonino , Olivieri Giuseppe 
Published: September 2021

AbstractMicroalgae technology has been extensively studied during the last two decades. Thousands of species were isolated, and few are currently used in the market for multiple purposes. The current comprehensive review focuses on a promising species named Neochloris oleoabundans. It encompasses a historical overview of the species followed by a detailed description of its taxonomy, ecophysiology and morphology. Furthermore, a thorough screening is conducted to outline the production conditions employed to grow the microalga. In addition, multiple cell disruption and fractionation methods previously applied on N. oleoabundans are described and discussed together with the value chain creation after applying all the unit operations.
A Numerical Model for Solving Three-Dimensional Rolling Contact Problems with Elastic Coating Layers
Authors: Xi Yinhu , Björling Marcus , Almqvist Andreas 
Published: September 2021

AbstractIn this work, a numerical model is proposed for three-dimensional rolling contact problems with one or two elastic layers, and the tangential contact solution is emphasized. Previous works on this topic have mostly been two-dimensional, in which only longitudinal creepage has been considered. With the three-dimensional model presented in this work, all possible creepages, such as the longitudinal, lateral and spin creepages are taken into account. In order to improve the calculation efficiency, the conjugate gradient method and the FFT technique are employed. The influence coefficients for displacement and stress are obtained from the corresponding frequency response functions. The numerical results are validated against existing results and good agreement can be found. The effects of the different layers’ thicknesses and elastic moduli under different creepage combinations on the traction distribution and stick/slip results are investigated. It can be seen that by adjusting the layer parameters the traction and stick/slip results can be modified significantly, and it may, therefore, be very useful information for improving the rolling contact fatigue and mitigating wear problems in various mechanical systems.
Graphical Abstract
How Many CPU Cores is an FPGA Worth? Lessons Learned from Accelerating String Sorting on a CPU-FPGA System
Authors: Asiatici Mikhail , Maiorano Damian , Ienne Paolo 
Published: September 2021

AbstractString sorting is a fundamental kernel of string matching and database index construction; yet, it has not been studied as extensively as fixed-length keys sorting. Because processing variable-length keys in hardware is challenging, it is no surprise that no hardware-accelerated string sorters have been proposed yet. In this paper, we present Parallel Hybrid Super Scalar String Sample Sort (pHS5) on Intel HARPv2, a heterogeneous CPU-FPGA system with a server-grade CPU. Our pHS5 extends pS5, the state-of-the-art string sorting algorithm for multi-core shared memory CPUs, by adding multiple processing elements (PEs) on the FPGA. Each PE accelerates one instance of the most effectively parallelizable among the dominant kernels of pS5 by up to 33% compared to a single Intel Xeon Broadwell core despite a clock frequency that is 17 times slower. Furthermore, we extended the job scheduling mechanism of pS5 to schedule the accelerable kernel not only among available CPU cores but also on our PEs, while retaining the complex high-level control flow and the sorting of the smaller data sets on the CPU. Overall, we accelerate the entire algorithm by up to 10% with respect to the 28-thread software baseline running on the Xeon processor and by up to 36% at lower thread counts. Finally, we generalize our results assuming pS5 as representative of software that is heavily optimized for modern multi-core CPUs and investigate the performance and energy advantage that an FPGA in a datacenter setting can offer to regular RTL users compared to additional CPU cores.
Social robots and digital well-being: how to design future artificial agents
Authors: Dennis Matthew J. 
Published: September 2021

AbstractValue-sensitive design theorists propose that a range of values that should inform how future social robots are engineered. This article explores a new value: digital well-being, and proposes that the next generation of social robots should be designed to facilitate this value in those who use or come into contact with these machines. To do this, I explore how the morphology of social robots is closely connected to digital well-being. I argue that a key decision is whether social robots are designed as embodied or disembodied. After exploring the merits of both approaches, I conclude that, on balance, there are persuasive reasons why disembodied social robots may well fare better with respect to the value of digital well-being.
Influence of Positive Parenting Styles on Self-Regulated Learning in Chinese Adolescents Testing the Mediating Effects of Self-Esteem
Authors: Du Wenbin , Jian Mengyan , Hua Fengrui , Qi Shaojie 
Published: September 2021

AbstractThe positive parenting styles and the self-esteem of the parents are two factors that affect Self-regulated learning (SRL). Moreover, the variable of self-esteem is influenced by the positive parenting styles. However, previous studies have investigated only the cross-sectional relationship between positive parenting styles and SRL and that between positive parenting styles and self-esteem. This study explored the relationship between positive parenting styles and self-regulated learning in Chinese adolescents and verified the mediating role of self-esteem in this relationship. The study used the panel data of 1180 1 adolescents (age, 10–15 years) from the 2014 China Family Panel Studies. The main variables were positive parenting styles, self-esteem, and SRL. The results showed that self-esteem plays a partial, but significant, mediating role in the relationship between parents’ positive parenting styles and adolescents’ SRL ability. This study emphasised that self-esteem is a variable that influences the SRL ability. The more active the parents are, the better the SRL ability of the adolescents is. Positive parenting styles have been proven to promote self-esteem development and can affect the SRL ability of adolescents.
Online-Elterntraining für die Behandlung von Kindern mit externalisierenden Verhaltensproblemen und affektiver Dysregulation
Authors: Ritschel Anne , Döpfner Manfred , Schürmann Stephanie , Plück Julia , Meyer Hanna , Schottel Marie , Ravens-Sieberer Ulrike , Roessner Veit , Banaschewski Tobias , Görtz-Dorten Anja , Kölch Michael , Treier Anne-Katrin , Hanisch Charlotte 
Published: September 2021

Zusammenfassung
Hintergrund
Aufmerksamkeitsdefizit‑/Hyperaktivitätsstörung (ADHS) oder oppositionelle Verhaltensstörung (OPP) gehen mit unruhigem, oppositionellem und aggressivem Verhalten, negativen Interaktionen zwischen Kind und Eltern und langfristig häufig mit belasteten Eltern-Kind-Beziehungen einher. Kognitiv-behaviorale Elterntrainings, die für die Behandlung externaler Störungen als evidenzbasiert gelten, versuchen problematische situative und Verstärkerbedingungen sowie negative Interaktionen zwischen Eltern und Kindern zu verändern.

Ziel
Es sollen Online-Selbsthilfetrainings für Eltern von Kindern mit externalisierenden Verhaltensproblemen entwickelt werden.

Methode
Bestehende Face-to-face-Elterntrainings wurden in Online-Formate überführt und inhaltlich erweitert. Eine Wirksamkeitsuntersuchung erfolgt im Rahmen von randomisierten Kontrollstudien.

Ergebnisse
Der ADHS-Elterntrainer richtet sich an Eltern von Kindern mit subklinischen sowie klinisch relevanten ADHS-Symptomen sowie ggf. komorbid weiteren externalen Symptomen. Er zielt darauf ab, Störungsverständnis aufzubauen, die elterliche Steuerung zu erhöhen und die Eltern-Kind-Beziehung zu verbessern. Bei Kindern mit Emotionsregulationsstörungen, sog. affektiver Dysregulation, ist darüber hinaus die elterliche Unterstützung beim Erwerb funktionaler Emotionsregulationsstrategien nötig. Für das ADOPT-Online-Elterntraining (affektive Dysregulation – Optimierung von Prävention und Therapie), das sich an Eltern von Kindern mit affektiver Dysregulation richtet, wurde das Konzept des ADHS-Elterntrainers um Interventionen zum Umgang mit negativen Gefühlen des Kindes und der Eltern erweitert.

Diskussion
Bei entsprechend positiven Effekten auf die kindliche Symptomatik innerhalb der Evaluationsstudien könnte das ADOPT-Online-Elterntraining wie bereits beim ADHS-Elterntrainer geschehen im präventiven oder therapeutischen Setting eingesetzt werden.
Irrigated trap crops impact key hemipteran pests in organic pistachio orchard
Authors: Stahl Judith M. , Wilson Houston , Straser Robert K. , Maccaro Jessica J. , Daane Kent M. 
Published: September 2021

AbstractUsing sown groundcovers as trap crops to protect a cash crop is a traditional pest management tool. Pistachio is a major crop in California’s Central Valley, where high summer temperatures and little to no precipitation between May and November lead to summer dry-down of annual groundcover. Hemipteran pests that consist of ‘small bugs’ and ‘large bugs’ are a major contributor to nut damage, especially in organic production. In this 2-year field study, we tested the use of irrigated trap crop mixtures, sown between tree rows, to reduce those hemipteran pests’ abundance or damage. Biweekly beat samples of the tree canopy and sweep samples of the sown groundcovers in trap crop plots and resident weedy vegetation in control plots were taken over two consecutive growing seasons. Arthropod richness and abundance were highest in the groundcover and tree canopy in the trap crop plots. Small and large bug pest populations were higher and lower, respectively, in the tree canopy in trap crop plots, indicating a mixed response of these hemipterans to the presence of the trap crops. Additionally, natural enemy populations were more abundant in the tree canopy in trap crop plots than in control plots. There was no difference in nut damage between plots with and without the trap crop. These findings suggest that populations of hemipteran pests and beneficials can be manipulated successfully with irrigated trap crops, but future studies will need to focus on doing so in a way that decreases hemipteran pistachio damage.
Different management of adrenocortical carcinoma in children compared to adults: is it time to share guidelines?
Authors: Grisanti Salvatore , Cosentini Deborah , Laganà Marta , Turla Antonella , Berruti Alfredo 
Published: September 2021

AbstractPediatric and adult adrenocortical carcinomas differ in many respects but treatment is often similar in both age groups. The Journal of Clinical Oncology recently published the results of a risk-stratified single-arm interventional trial conducted by the Children’s Oncology Group in which 77 patients were treated in three different interventional cohorts. In this Point of View paper we comment on the treatment strategies adopted within the ARAR0332 trial in terms of surgery approach, duration of adjuvant therapies, and palliative chemotherapy. We focus on the differences in the treatment of pediatric ACC patients compared to the ESE/ENSAT and ESMO guidelines released in 2018 for adult patients. For example, patients in stratum 3 and 4 received 8 (instead of 6) cycles of EDP chemotherapy but 8 months (instead of 24) of mitotane adjuvant therapy. Bearing clearly in the mind that pediatric and adult ACC patients represent different settings, we wonder whether there could be some areas of intervention overlapping to constitute a continuum of disease across ages. Thus, pediatric and adult cohoperative groups should be encouraged to collaborate in order to reach common guidelines for the treatment of such a rare disease.
Green criminological perspectives on dog-fighting as organised masculinities -based animal harm
Authors: Nurse Angus 
Published: September 2021

AbstractDog-fighting was historically a working-class pursuit within predominantly white, working-class subcultures, representing a distinct type of organised animal exploitation. However, contemporary dog-fighting has moved way from its organised pit-based origins to encompass varied forms of organised activity including street dog-fighting in the form of chain fighting or chain rolling, the use of dogs as status or weapon dogs. This paper examines dog-fighting from a green criminological perspective as a distinct form of organised and subcultural crime. Analysis of UK legislation identifies that the specific offence of ‘dog-fighting’ does not exist. Instead, dog-fighting is contained within the ‘animal fighting’ offence, prohibited by provisions of the Animal Welfare Act 2006. However, beyond the actual fight activities (pitting dogs against each other or attacking humans), a range of other offences are associated with dog-fighting including: illegal gambling; attending dog-fighting events; animal welfare harms; and the breeding and selling of dogs for fighting. This paper’s analysis examines contemporary legal perspectives on such activities; also discussing how illegal fieldsports (e.g. dog-fighting and cock-fighting) are dominated by organised crime elements of gambling and distinctly masculine subcultures through which a hierarchy of offending is established and developed. Commensurate with previous research that identifies different offender behaviours and offending within animal crime, this paper concludes that variation exists in the nature of dog-fighting to the extent that a single approach to offenders and offending behaviour is unlikely to be successful.
Moral sensitivity in business: A revised measure
Authors: Schmocker David , Tanner Carmen , Katsarov Johannes , Christen Markus 
Published: September 2021

AbstractIn order to manage ethical challenges in organizations and the workplace, moral sensitivity (MS)—the ability to identify and ascribe importance to moral issues when they arise in the workplace—is seen as the key prerequisite by researchers and professionals. However, despite the importance of MS, satisfactory reliable and valid measures to assess this competence are to date lacking. The present research tests the psychometric qualities of a revised MS measure for the business domain (R-MSB) that is designed to assess individual differences in moral and business-related value sensitivity. We present three different analyses with two heterogeneous samples of Swiss and German employees (total N = 1168). The first two studies provide good evidence of the measures’ factorial structure, its construct, and criteria-related validity. The third study examines how affective and empathic responses are associated with MS and business sensitivity (BS). The results support the view that empathic responsiveness enhances MS. The instrument’s theoretical and practical strengths, limitations, and avenues for future research are discussed.
Ameloblastoma and Intracranial Involvement: The Current Challenge of the Radical Surgical Treatment. Comprehensive Review of the Literature and Institution experience
Authors: Armocida Daniele , Berra Luigi Valentino , Pucci Resi , Battisti Andrea , Della Monaca Marco , Valentini Valentino , Santoro Antonio 
Published: September 2021

Abstract
Background
Ameloblastoma (AMBL) is an odontogenic tumor, considered to be benign, but aggressive, whose principal risk is a recurrence. The growth can be enormous, and it can extend into the intracranial compartment with serious consequences.

Purpose
The intracranial involvement of AMBL is rare, and it may require an extensive surgery. Although it is a rare condition for the neurosurgeon to treat, knowing this condition can lead to a significant increase in survival for these patients.

Methods
A case of a 56-year-old woman presented with a history of recurrent left maxilla AMBL with intracranial extension and dural involvement of the anterior and medial cranial fossa is reported, followed by a systematic review of the literature with the aim to identify the best surgical treatment.

Results
A total of 32 cases were included in the qualitative analysis. Management is varied and often not described, resulting in an almost complete lack of information and indications for treatment. Radical surgery tends to yield the best outcomes, and it is recommended to have adequate surgical margins when possible.

Conclusions
Intracranial involvement from AMBL compartment is an uncommon manifestation of this rare pathology, but which deserves to be treated in a multidisciplinary way in order to ensure maximum surgical radicality. Recurrence reflects failure of the primary surgical resection. If recurrence is the major consideration, surgeons are encouraged to select radical surgery. Whenever a follicular-type maxillary AMBL is diagnosed, it is advisable to check for intracranial spreading and distant metastases during follow-up.
Establishment of a Modular Hemodynamic Simulator for Accurate In Vitro Simulation of Physiological and Pathological Pressure Waveforms in Native and Bioartificial Blood Vessels
Authors: Helms Florian , Haverich Axel , Wilhelmi Mathias , Böer Ulrike 
Published: September 2021

Abstract
Purpose
In vitro stimulation of native and bioartificial vessels in perfusable systems simulating natural mechanical environments of the human vasculature represents an emerging approach in cardiovascular research. Promising results have been achieved for applications in both regenerative medicine and etiopathogenetic investigations. However, accurate and reliable simulation of the wide variety of physiological and pathological pressure environments observed in different vessels still remains an unmet challenge.

Methods
We established a modular hemodynamic simulator (MHS) with interchangeable and modifiable components suitable for the perfusion of native porcine—(i.e. the aorta, brachial and radial arteries and the inferior vena cava) and bioartificial fibrin-based vessels with anatomical site specific pressure curves. Additionally, different pathological pressure waveforms associated with cardiovascular diseases including hyper- and hypotension, tachy- and bradycardia, aortic valve stenosis and insufficiency, heart failure, obstructive cardiomyopathy and arterial stiffening were simulated. Pressure curves, cyclic distension and shear stress were measured for each vessel and compared to ideal clinical pressure waveforms.

Results
The pressure waveforms obtained in the MHS showed high similarity to the ideal anatomical site specific pressure curves of different vessel types. Moreover, the system facilitated accurate emulation of physiological and different pathological pressure conditions in small diameter fibrin-based vessels.

Conclusion
The MHS serves as a variable in vitro platform for accurate emulation of physiological and pathological pressure environments in biological probes. Potential applications of the system include bioartificial vessel maturation in cardiovascular tissue engineering approaches as well as etiopathogenetic investigations of various cardiovascular pathologies.