bluuebunny/crossref_metadata_2025_split huggingface dataset:
Have Norwegians tried psilocybin, and do they accept it as a medicine?
Authors: Jacobsen Henrik Børsting , Stubhaug Audun , Holmøy Bjørn , Kvam Tor Morten , Reme Silje Endresen 
Published: April 2021

AbstractBackgroundPsilocybin is emerging as a promising therapeutic agent for a wide range of psychiatric conditions, and clinical trials on psilocybin-assisted treatment are forthcoming in Scandinavian countries. However, little is known about attitudes towards this psychedelic compound among the general public in Nordic countries. This might represent a confound, and reduce the validity of research findings or the overall feasibility of conducting high-quality clinical trials.AimsThe main objective of this study is to address the knowledge gap surrounding use and attitudes towards psilocybin in Norway.MethodsWe asked a representative sample of the Norwegian population (N = 1,078) if they have ever tried psilocybin and if they would be willing to do so as part of medical treatment. These questions were part of a larger online survey on a variety personal preferences and attitudes, and the survey was not presented as a study on psilocybin.ResultsOf the 1,078 respondents, 8% reported previous psilocybin use and 51% were willing to try psilocybin in medical treatment.ConclusionsPsilocybin use is more common in Norway than the authors hypothesized, and the general public is relatively open to using psilocybin in a medical context. The latter is interpreted as promising with regards to the feasibility of conducting rigorous clinical trials on potential effects and side effects of psilocybin-assisted treatment in Norway.
Glycemia in patients with type 2 diabetes during inpatient treatment for acute myocardial infarction: impact on prognosis
Authors: Korotina M. A. , Pochinka I. G. , Frolov A. A. , Botova S. N. , Strongin L. G. 
Published: April 2021

Aim. To investigate the relationship between abnormal glycemia levels during inpatient treatment for acute myocardial infarction (AMI) in patients with type 2 diabetes (T2D) and long-term prognosis.Material and methods. The single-center cohort study included patients with AMI and concomitant T2D who were hospitalized consecutively for 200 days. A total of 237 patients were included. The median number of blood glucose measurements during hospitalization was 15 [8; 20] times. Long-term outcome was estimated at 365 days after hospitalization.Results. The first glycemic value on admission was 13,6±5,9, while the average glycemia during hospitalization was 10,0±3,5 mmol/L. Within 12 follow-up period, 53 deaths were recorded. It was found that exceeding the glycemic threshold of 10,0 mmol/L in more than 45% of measurements during hospitalization was associated with a 3-fold increase in the risk of an unfavorable outcome within 12 months. Predictors of poor glycemic control are insulin therapy before MI and blood glucose at admission >12,1 mmol/L.Conclusion. Poor glycemic control (>45% of glucose measurements above the threshold of 10,0 mmol/L) during hospitalization for AMI in patients with T2D is associated with an increased risk of in-hospital death and during the next 12 months, including in patients who underwent endovascular treatment.
Carbohydrate metabolism disorders in patients with heart failure: data from the local registry
Authors: Vaisberg A. R. , Tarlovskaya E. I. , Fomin I. V. , Polyakov D. S. , Omarova Yu. V. 
Published: April 2021

Aim. To study the prevalence of carbohydrate metabolism disorders in patients with heart failure (HF) hospitalized in the city HF center.Material and methods. According to the local registry, the study sequentially included 183 patients (99 men and 84 women) hospitalized in the Nizhny Novgorod city HF center from September 1, 2019. The examination and treatment were carried out in accordance with the current clinical guidelines. In the first 48 hours after hospitalization, the concentration of the N-terminal pro-brain natriuretic peptide, soluble stimulating growth factor 2 (sST2), neutrophil gelatinase-associated lipocalin, cystatin C, blood creatinine was determined. The glomerular filtration rate was calculated using the СKDEPI equation. To assess the carbohydrate metabolism disorders, all patients were studied for fasting plasma glucose, glycated hemoglobin (HbA1c) and fructosamine. Statistical data processing was carried out using the R statistics package (R Core Team (2019)).Results. The incidence of carbohydrate metabolism disorders among patients withdecompensated HF was 75,89%, including previously diagnosed type 2 diabetes in 31,25%, newly diagnosed dysglycemia in 44,64% of patients. Less than one fourth of patients had normal parameters of carbohydrate metabolism according to HbA1c, fructosamine and fasting plasma glucose. The severity of carbohydrate metabolism disorders was significantly correlated with the severity of HF according to the following criteria: 6-minute walk test, HF functional class, sST2 level, and some parameters of cardiac remodeling. Among the criteria used for carbohydrate metabolism disorders, the HbA1c level was most closely associated with the criteria for HF severity.Conclusion. Carbohydrate metabolism disorders in HF patients are widespread and underdiagnosed during routine examination. The interrelation of carbohydrate metabolism parameters and indicators of HF severity is rationale for active detection of dysglycemia in these patients in order to potentially influence the prognosis.
The Global Graphic Protest Narrative: India and Iran
Authors: Salmi Charlotta 
Published: April 2021

AbstractThis article situates the graphic narrative form within the current politics of protest movements. It argues that the graphic narrative captures the forms of civil disobedience that shape late-twentieth-century and twenty-first-century protest. Protest movements increasingly operate within, or in accordance with, the systems they seek to challenge. The graphic narrative, similarly, combines complicity and critique in its narrative style and structure. The argument draws on two examples from different regional and political contexts—Vishwajyoti Ghosh's graphic narrative about the years of emergency rule in India in the 1970s,Delhi Calm, and Amir Soltani and Khalil's work on Iran's Green movement,Zahra's Paradise—to show how the global graphic narrative acts as an archive of popular protests that inform present-day movements and offers a platform for those movements to perform civic action. It advocates a new formalist approach to the global graphic narrative as a popular protest form.
Practice of insulin injection techniques among persons with diabetes in central India: an observational survey
Authors: Choudhary Animesh , Chouhan Jitendra , Gulati Sanjeev , Vishandasani Jogesh Kumar 
Published: April 2021

Background: Correct injection technique used by the patient can determine the outcomes with insulin therapy in type 2 diabetes mellitus, however most patients on insulin remain unaware of the proper insulin injection techniques. The purpose of this study was to assess the current practice of insulin administration among diabetes patients.Methods: This cross-sectional study was conducted in 3 tertiary care centers delivering specialized diabetes care in central India from November 2019 to February 2020. The study included patients (n=150) using insulin for at least three months by either syringe or pen. All of them answered a survey questionnaire which focused on key insulin injection parameters.Results: Abdomen was the most common (53.33%) site of insulin injection. About 95.33% of subjects were following the injection site rotation instructions. The practice of hand washing, and cleaning of the injection site was practiced by 120 (80%) and 112 (74.66%) respondents respectively. Needle reuse was a common practice, and 146 (97.33%) subjects were using the same needle more than once. Around 73.33% were storing insulin at proper temperature, while 54.66 % reported having pain at the injection site and 14.66% had noticed persistent swelling at their injection sites. Conclusions: There is a signiﬁcant gap between the insulin administration guidelines and current insulin injection practice. Education and counseling about proper insulin injection techniques should be provided to all persons with diabetes to ensure optimal usage of the drug to achieve the desired glycemic control.
Prevalence of Antenatal Depression and Its Associated Risk Factors Among Pregnant Mothers Attending Antenatal Care Service at Jinka Public Health Facilities, Southern Ethiopia
Authors: Yetwale Aynalem , Gultie Teklemariam , Ajema Dessalegn , Afework Bezawit , Tilahun Semahegn 
Published: April 2021

BACKGROUNDAntenatal depression is the most common psychiatric disorder during pregnancy with serious consequences for the mother and the fetus. However, there are few studies about this health issue in developing countries. This study aimed to determine the prevalence of antenatal depression and its associated risk factors among pregnant mothers attending antenatal care service at Jinka public health facilities, south Omo zone, Southern Ethiopia.METHODSInstitutional-based cross-sectional study design was conducted on 446 pregnant women at Jinka public health facilities, from June 1 to June 30, 2018. Beck Depression Inventory was used to assess women's level of depression. Statistical package for social science version 20.0 was used for analysis. Logistic regression was used to find out the association between explanatory and depression. The strength of association was evaluated using odds ratio at 95% confidence interval (CI).RESULTThe magnitude of antenatal depression in this study was 24.4% (20.2–28.5 at 95% CI) and it had statistically significant association with unmarried marital status adjusted odds ratio (AOR) = 13.39 [(95% CI); (3.11–57.7)], chronic medical illness AOR = 3.97 [(95% CI); (1.07–14.7)], unplanned pregnancy AOR = 6.76 [(95% CI); (2.13–21.4)], history of abortion AOR = 2.8 [(95% CI); (1.14–7.02)], history of previous pregnancy complication AOR = 4.8 [(95% CI); (2.12–17.35)], and fear of pregnancy-related complications AOR = 5.4 [(95% CI); (2.32–12.4)].CONCLUSIONSNearly one pregnant woman develops antenatal depression in every four pregnant women. Variables like unmarried marital status, chronic medical illness and unplanned pregnancy, history of previous pregnancy complications, and fear of pregnancy-related complications were associated with antenatal depression. Therefore, it is recommended that these risks factors should be evaluated during antenatal care with a view to improving maternal health.
Translation and Validation of the Birth Satisfaction Scale-Revised in Urdu for Use in Pakistan
Authors: Zafar Shamsa , Tayyab Fareeha , Liaqat Asma , Sikander Siham , Hollins Martin Caroline J. , Martin Colin R. 
Published: April 2021

BACKGROUNDSatisfaction with the birth experience is increasingly recognized as critical to the well-being of mother and baby and thus accurate assessment of this key dimension is essential. The Birth Satisfaction Scale-Revised (BSS-R) has been shown to be a robust, valid, and reliable measure of birth experience. The current study sought to develop an Urdu version of the measure to be used in Pakistan.METHODSFollowing translation, a cross-sectional design was used to examine the measurement properties of the Pakistan (Urdu)-BSS-R (P-BSS-R). Participants were a purposive sample of Pakistani postnatal women (n = 200). Key psychometric properties were examined using Confirmatory Factor Analysis (CFA), internal consistency evaluation, and known-groups discriminant validity testing.RESULTSThe majority of measurement parameters for clinical application of the P-BSS-R were found to be acceptable with good known-groups discriminant validity and data fit to the tri-dimensional theoretical model of the BSS-R observed. However, some idiosyncratic observations were highlighted, including unexpected low internal consistency.CONCLUSIONSThe P-BSS-R was found to be a generally valid and reliable measure of the experience, a caveat being low internal consistency warranting further investigation.
New Epizootic Territory in Gorno-Altai High-Mountain Natural Plague Focus on the Ukok Plateau
Authors: Korzun V. M. , Denisov A. V. , Bazarova G. Kh. , Sanarov P. P. , Shefer V. V. , Kholin A. V. , Chipanin E. V. , Mishchenko A. I. , Rozhdestvensky E. N. , Balakhonov S. V. 
Published: April 2021

The aim of the work – analysis of peculiarities of the plague epizooty found in the southern steppe part of the Ukok Plateau in 2020.Materials and methods. Epizootiological survey was conducted over the area of 1573 km2 in July and August, 2020. 141 mammals, 157 ectoparasites (including 152 fleas), 17 bone remains samples, and 50 regurgitates of predatory birds have been tested for plague.Results and discussion. The background species of mammals – natural hosts of Yersinia pestis in the southern steppe part of the Ukok plateau are gray marmot, long-tailed souslik, and Daurian pika. Abundance of the gray marmot was high and amounted to 1.7±0.18 inhabited burrows per 1 ha (n=30) with 90 % occupancy. Three strains of Yersinia pestis ssp. pestis have been isolated: from Oropsylla alaskensis fleas collected from long-tailed souslik, gray marmot carcass, and regurgitates of predatory birds. Yersinia pestis DNA have been detected in 14 objects. Eight positive results of serological tests have been obtained. The epizooty area that was confirmed by Yersinia pestis isolation totaled 252 km2 . As a result of the survey the circulation of Yersinia pestis ssp. pestis have been for the first time established on the Ukok Plateau. The target species – the gray marmot, as well as the long-tailed souslik, are actively involved into the epizooty.
Molecular-Genetic Monitoring of SARS-CoV-2 Genovariants in the Territory of the Volga Federal District of the Russian Federation. Communication 1
Authors: Osina N. A. , Krasnov Ya. M. , Guseva N. P. , Boolgakova E. G. , Domanina I. V. , Katyshev A. D. , Utkin D. V. , Vinogradova O. V. , Kudryashov N. V. , Polunina T. A. , Krasovskaya T. Yu. , Portenko S. A. , Shcherbakova S. A. , Kutyrev V. V. 
Published: April 2021

Emergence of various genovariants of the SARS-CoV-2 virus, which are characterized by a higher ability to spread and a more severe clinical manifestations compared to the initial variants, require molecular-genetic monitoring of strains circulating in the Russian Federation.The aim of the work was to identify the VOC SARS-CoV-2 genovariants in the territory of the Republics of Bashkortostan, Tatarstan, Udmurtia, and Samara, Penza, Saratov, Ulyanovsk, and Orenburg Regions.Materials and methods. The identification of genovariants and the determination of the type of mutations was carried out by the Sanger fragment sequencing method.Results and discussion. The study examined 298 samples of clinical material obtained from the Centers for Hygiene and Epidemiology in the Republics of Bashkortostan, Tatarstan, Udmurtia, Samara, Penza, Saratov, Ulyanovsk, and Orenburg Regions. In 17 % of cases, the variability of the SARS-CoV-2 virus was observed for one or more markers: in three samples, a new coronavirus of the B. 1.1.7 line (“British”) was detected; in a number of cases, only one mutation was detected in the virus found in samples – deletion Y144 or substitution D138Y, E484K, N501Y, and very rarely two mutations – deletion Y144 and substitution E484K. The presence of the L141-G142-V143 deletion localized in the recurrent deletion region RDR2 of the S-gene was shown in 10 % of the cases. The data obtained indicate the heterogeneity in macroorganism of the population of the new coronavirus with the deletion L141-G142-V143, which leads to a change in the antigenic structure of the virus, which probably allows the virus to evade the immune response.
Characteristics of the Epidemiological Situation on Cholera in the World and in the Russian Federation in 2020 and Forecast for 2021
Authors: Noskov A. K. , Kruglikov V. D. , Moskvitina E. A. , Monakhova E. V. , Levchenko D. A. , Yanovich E. G. , Vodop’yanov A. S. , Pisanov R. V. , Nepomnyashchaya N. B. , Ezhova M. I. , Podoinitsyna O. A. 
Published: April 2021

Aim of the work – to assess the epidemiological situation on cholera in 2020 and to make a forecast for 2021 based on the monitoring data and analysis of morbidity around the world for the period of 2011–2020. During the period between 2011 and 2020, 4 413 988 cases of cholera were recorded in 97 countries of the world with a general trend towards a decrease in the incidence (coefficient of accuracy of approximation R2 – 0.5705). However, due to the continuing epidemic manifestations of cholera in the endemic countries of Asia, Africa and America, the epidemiological situation on cholera on these continents was characterized as unfavorable in 2020. The emergence of a new “post-Haitian” lineage was observed among epidemically hazardous strains of Vibrio cholerae O1. In 2020, no epidemically dangerous strains of V. cholerae O1, O139 were isolated from humans on the territory of the Russian Federation. 25 non-toxigenic V. cholerae O1 El Tor strains were isolated from environmental objects, eight out of which (ctxA-, tcpA+), according to PCR-INDEL typing and SNP analysis of sequences, belonged to the clonal complex. The results of the analysis of biological properties and phylogenetic relations between the isolated non-toxigenic strains provided the basis for considering the epidemiological situation on cholera in Russia in 2020 as a stable one and a similar forecast of its development in 2021. At the same time, the possibility of importation of this infection from endemic countries cannot be ruled out, as well as the need to carry out a complex of differentiated anti-epidemic (preventive) measures within the framework of the state sanitary-epidemiological surveillance in order to localize and eliminate the imported focus and avoid the spread of the infection.
Petrology of Basanitic Lavas of the Daur–Hentiyn Range (P–T Conditions of Formation, Crystallization Sequence, and Sources of Material)
Authors: Medvedev A.Ya. , Demonterova E.I. , Karimov A.A. , Belyaev V.A. 
Published: April 2021

Abstract
—We performed a comprehensive study of basanites from the Daur–Hentiyn Range and present the first data on their Sr and Nd isotope and mineral compositions (electron probe microanalysis). The study has shown that the basanites are chemically similar to the volcanic rocks of the South Baikal volcanic area (SBVA) and are slightly different from oceanic island basalts in higher contents of Ba, Th, La, and Sr. The crystallization temperatures and pressures for the Fo0.85 olivine–melt equilibrium have been estimated, 1186–1137 ºC, 1.09–1.06 GPa, and the sequence of mineral crystallization has been established. The obtained Sr and Nd isotope data indicate that the basanitic magmas were generated from material with PREMA and EMI isotope parameters.
Crust–Mantle Xenoliths from the Kharchinsky Volcano (Central Kamchatka Depression): Mineralogy and Petrogenesis
Authors: Sekisova V.S. , Smirnov S.Z. , Kuzmin D.V. , Shevko A.Ya. , Gora M.P. 
Published: April 2021

Abstract
—We present results of a study of plutonic-rock xenoliths from the Kharchinsky Volcano (Central Kamchatka depression). The studied xenolith collection comprises nine samples of peridotites and clinopyroxenites. The peridotites are identified as wehrlites, dunites, and harzburgites composed of olivine, clino- and orthopyroxenes, amphibole, and chromite in varying amounts. The clinopyroxenites consist mostly of clinopyroxene and often contain subordinate olivine, amphibole, hercynite, and magnetite. The xenoliths have interstitial segregations and veins composed of chlorite, plagioclase, K-feldspar, orthopyroxene, barite, fluorapatite, ilmenite, and, more seldom, anhydrite, phlogopite, and some other minerals. The study has revealed that veinlet minerals sometimes replace primary minerals and form pseudomorphs, thus indicating the metasomatic origin of interstitial and vein mineral assemblages. The thermobarometric calculations for minerals have shown that peridotites formed at ~1140 °C and ≤10 kbar in the intermediate chambers at the depths from the spinel stability field to the Moho. Interstitial metasomatic alterations of rocks took place at ~400–850 °C.
Activated Carbon Impregnated by Zero-Valent Iron Nanoparticles (AC/nZVI) Optimized for Simultaneous Adsorption Furfural: Green Synthesis, Regeneration, Characterization, and Adsorption-Desorption Studies
Authors: Rashtbari Yousef , Afshin Shirin , Hamzezadeh Asghar , Ghosh Soumya , Rastegar Ayoob , Poureshgh Yousef , Ahmadi Shahin , Sher Farooq 
Published: April 2021

Abstract
Furfural is an organic aromatic compound that has attracted considerable interest as a potential chemical for the production of biochemical and biofuels. However, furfural has proved to possess ecotoxic effect on the environment and to humans, therefore measures are required to prevent these effects. One of the most widely used methods for eliminating furfural is the surface adsorption process.The present study focused on the structure and morphology of the composite nanoparticles, investigated using FTIR, XRD, BET and FE-SEM techniques.Furthermore, the variables of time, solution pH, dosage composite and initial furfural were evaluated. Furfural adsorption was performed by spectrophotometer at a wavelength of 227 nm. The removal efficiency under optimal conditions for furfural (Furfural concentration of 250 mg/L, the composite dose of 4 g/L, the reaction time of 60 min and pH = 7) was 81.46%. In addition, the study of isotherm and adsorption kinetics for furfural showed that the adsorption process follows the Langmuir isotherm and quasi-quadratic kinetics. The qmax of the composite was determined by the Langmuir model of222.22 mg/g. Therefore, the present study exclusively showedthat the activated carbon coated with nZVI nanoparticles used as an effective and environmentally friendly adsorbent for furfural removal from aqueous solutions. Furthermore, this study could possibly have applied for the adsorbtion of other chemical cmpounds such as dyes,metronidazole,aniline.
Modeling Shear Strength of Medium- to Ultra-High-Strength Concrete Beams with Stirrups using SVR and Genetic Algorithm
Authors: Jiang Chun-song , Liang Gui-Qin 
Published: April 2021

Abstract
This paper presents a data-driven machine learning approach of support vector regression (SVR) with genetic algorithm (GA) optimization approach called SVR-GA for predicting the shear strength capacity of medium-to ultra-high strength concrete beams with longitudinal reinforcement and vertical stirrups. 148 experimental samples collected with different geometric, material and physical factors from literature were utilized for SVR-GA with 5-fold cross validation. Shear influence factors such as the stirrup spacing, the beam width, the shear span-to-depth ratio, the effective depth of the beam, the concrete compressive and tensile strength, the longitudinal reinforcement ratio, the product of stirrup ratio and stirrup yield strength were served as input variables. The simulation results show that the predicted shear strength of SVR-GA model can achieve high accuracy based on testing set with a coefficient of determination (R2) of 0.9642, root mean squared error (RMSE) of 1.4685 and mean absolute error (MAE) of 1.0216 superior to that for traditional SVR model with 0.9379, 2.0375 and 1.4917. The sensitivity analysis reveals that the most important variables affecting the prediction of the shear strength are shear span-to-depth ratio, concrete compressive strength, reinforcement ratio and the product of stirrup ratio and stirrup yield strength. Three-dimensional input/output maps can vividly reflect the nonlinear variation of the shear strength with the two coupling variables. All in all, the proposed SVR-GA model presents an effective and accurate artificial intelligence technology for modeling the shear strength of ultra-high strength concrete beams with stirrups.