bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESIGN EXPERT SUPPORTED FORMULATION DEVELOPMENT, MATHEMATICAL OPTIMIZATION AND PREDICTABILITY STUDY OF FLOATING TABLETS OF BISOPROLOL FUMARATE
Authors: AHMAD SHAIKH SHAOOR , N. SHAIKH SIRAJ , SIDDIK PATEL M. , YUNUS KHALIFA MAHMADASIF , I. MAKRANI SHAHARUKH , A. SIDDIQI HIFZURRAHMAN MD , ISMAIL SHAIKH SALMAN 
Published: March 2021

Objective: Focus of the study was to formulate Design expert Software assisted floating tablet of Bisoprolol Fumarate. Bisoprolol Fumarate is a Beta adrenergic blocking agent, used to treat cardiac diseases favorable characters to be formulated as sustained release Gastro retentive floating tablets.
Methods: Floating Tablets of Bisoprolol Fumarate were prepared by using polymers such as Polyox N 12 K and Carbapol 940 P. Formulations were prepared by using direct compression method and evaluated for various parameters like Hradness, thickness, weight variations, Floating lag time Total floating time,% drug release and Stability Study etc.
Results: FTIR spectroscopic study indicates no drug-excipients interaction in the prepared formulations. Hardness or crushing strength of the tablets of all the formulation was found between 5.8 and 6.5 kg/cm2. Floating lag time of all batches is in range of 1.18±2.0 to 2.43±1.6 (minutes). All other parameters of all batches are within an acceptable range. The polymer Carbopol 940 P had the significant negative effect of on the floating lag times. The In vitro dissolution profiles of optimized A3 Floating formulation of Bisoprolol Fumarate were found to sustain drug release 99.25 % up to 12 h with floating lag time of 1.45 min; Designed formulation was stable after Stability study. Optimization study was carried out by using 32 factorial designs to fabricate formulations.
Conclusion: It can be conclude that reproducible results of various parameters in this developed formulation can easily scale up. Furthermore designed formulation will be very effective for controlling blood pressure.
An experimental study of a shear connection of steel-reinforced concrete slabs with angle shear studs
Authors: Tonkih Gennadij P. , Chesnokov Denis A. 
Published: March 2021

Introduction. Angle shear studs, attachable by powder-actuated fasteners, are used as an alternative to traditional welded elements ensuring the shear connection of steel-reinforced concrete slabs. The objective is to revise their strength characteristics for different options of steel-reinforced concrete slab designs pursuant to SP 266.1325800.2016.
Materials and methods. The programme of laboratory tests was developed in compliance with GOST R 58336-2018 to identify the strength behaviour of angle shear studs. Static shear testing of angle studs was performed at the LISMIiK laboratory of the Moscow State University of Civil Engineering using universal servo-hydraulic reconfigurable testing machine MTS.Multiaxial.DS1.4811.DS1.50019, designated for the testing of static and dynamic loads applied to large constructions. Displacements were measured by a tripod-mounted piston-type indicator.
Results. The programme of theoretical and experimental research into the behaviour of a shear connection with angle shear studs in steel-reinforced concrete slabs that also had steel deck profile sheets was developed on the basis of the analysis of regulatory documents and sources of research information. Laboratory tests showed that the strength of the shear connection in an angle stud depends not only on the geometry of the steel deck, used as the stay-in-place formwork, but also on the position of a shear stud in the deck.
Conclusions. The results of the theoretical and experimental research can be used to obtain new information about the strength and deformability of angle shear studs, connected by powder-actuated fasteners with the help of high strength expansion anchors; they allow to revise the currently used provisions governing the calculation of the reduction factor pursuant to SP 266.1325800.2016 with account taken of the design parameters of a shear connection.
FORMULATION AND EVALUATION OF PHARMACEUTICALY STABLE SERUM OF DUCHESNEA INDICA (ARBENAN)
Authors: Mursyid A. Mumtihanah , Waris Risda 
Published: March 2021

Objective: Arbenan (Duchesnea indica) plants contain saponins, flavonoids, and tannins which have antioxidant activity. The purpose of this research is to perform formulation and evaluation extract ethanol of Arbenan leaves in the form of serum which is pharmaceutically stable.
Method: Arbenan leaf powder was macerated with ethanol solvent, and then left for 3-4 days while stirring repeatedly, and then filtering. Furthermore, the liquid ethanol extract that has been obtained is evaporated using a Rotary Vacum Evaporator was used to evaporate the extract. Prepared extract was used to evaluate various parameters like organoleptics, homogeneity, viscosity, and pH.
Result: All formulations were having typical smell, light brown color and a little thick consistency. Formulations of leaf extract of Arabenan with four variations bases have shown to have good stability after stress condition. It can be seen from the evaluation result are organoleptics, homogeneity, viscosity, rheology, and pH.
Conclusion: Study concludes that a stable leaf extract of Arabenan can be effectively formulated into a serum by the means of various bases.

Peer Review History:
Received 8 January 2021; Revised 13 February; Accepted 4 March, Available online 15 March 2021
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 5.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewer(s) detail:
Dr. Marwa A. A. Fayed,
University of Sadat City, Egypt, maafayed@gmail.com
Prof. Dr. Ali Gamal Ahmed Al-kaf,
Sana'a university, Yemen, alialkaf21@gmail.com
Ahmad Najib,
Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id
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Authors: Che Daud M Faizal , Shaffee Siti Nur , Myo Thant Maung Maung 
Published: March 2021

Abstract
Excessive sand production is synonymous with aging fields and increased water production. Some offshore fields in Malaysia produce sand in the range of tonnes per day. Conventionally, the produced sand needs to be sent onshore for treatment, increasing the OPEX for a field with an already declining production. This paper presents a newly developed technology to help operators in handling and disposal of produced sand offshore.
A hybrid system of a unique mechanical agitation and the chemical solution was developed for offshore sand cleaning. The system aims to remove Oil-in-Water (OIW) and Oil-in-Sand (OIS) content according to the local regulations and requirements for offshore disposal. In the lab-scale screening, the best performing deoiling chemical for oil removal from the sand was achieved using novel chemical formulations containing surfactants with higher water affinity (hydrophilic). In the bench-scale prototype evaluation, the deoiling chemical was coupled with a mechanical system. A semi-automated, pilot-scale unit with the capacity to handle approximately 1 metric tonne of oily sand was constructed and used for further testing.
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It has been shown that a superior cleaning quality meeting the onboard disposal specification can be achieved via this system compared to existing technology which is based on only mechanical means. An example of potential sand cleaning system integration and tie-in to an existing offshore facility with excessive sand production is also discussed in this work. The compact sand cleaning system is a novel technology to reduce OIS content, leading to reduced sand handling and disposal OPEX for aging fields.
Drill Bits Evolution in Lump-Sum Turnkey Project Delivers Up to 70 Percent ROP Improvement
Authors: Ullah Syed Zahoor , Ruzhnikov Alexey , Siddik Syed , Sizov Maxim , Alfakih Abdulqawi 
Published: March 2021

Abstract
Drilling rate of penetration (ROP) is one of the variables that influences well delivery timing and cost. ROP is affected by many factors, including but not limited to rock strength, well profile, bottom hole assembly (BHA) design, challenging formations per section, and drill bit selection. In one of the drilling projects in the Middle East, the primary method chosen to improve well delivery is to focus on optimizing the drill bit design to improve ROP while delivering other drilling objectives.
As the project progressed, the ROP plateaued in most of sections in the field. The drilling team collaborated with the drill bit engineering to launch a drill bit optimization campaign in various hole sizes ranging from 16-in to 6⅛-in.
Since fixed-cutter bits are predominantly used in these sections, improvements are made to the existing drill bit designs by replacing the cutting elements with more efficient 3D polycrystalline diamond compact (PDC) cutters or 3DC. 3DC cutters have different shapes, uniquely designed to tackle different drilling challenges.
Using an in-house petrophysical log analysis program, each formation drilled in this field was analyzed and drilling challenges and ROP values were compared against previous performance. This information paired with finite element analysis (FEA) for dynamic drilling simulation was used to optimize drill bit selection. This conceptual workflow was followed to avoid costly field tests and ensure that the newly designed drill bit performs flawlessly downhole.
Other design elements, such as choosing bit body material, were also incorporated by converting matrix-bodied to steel-bodied, which not only improved the ROP but also reduced the cost-per-foot (CPF).
Initially the bit optimization program enabled ROP improvement in the 16-in section by 36% from 53 ft/h to 73 ft/h by replacing the roller-cone bit with a matrix-bodied fixed-cutter bit. Moreover, the drilling team further improved their performance, achieving 118 ft/hr. ROP when using the steel-bodied bit.
With successful deployment of 3DC cutters in Middle East, ridged diamond element was introduced in the 8½-in section and successfully improved overall ROP by 11%. In addition, the 6⅛-in section showed 25% improvement in ROP following several design iterations that utilized two different types of 3DC cutters. By the end of the drill bit optimization campaign, the operator was able to improve the drilling curve and save up to 2.5 days per well. The 3DC cutters also helped eliminate the risk of bit failure in the 8½-in section, wherein offset wells several bits were required to complete the section.
With the performance mindset, new technology deployment made it faster to test new bit designs. This helped with getting early data point for analysis before being able to test in the different fields in the area.
First Attempt of Injection-Production Integrated Technology for Steam Stimulation in Bohai Bay, China
Authors: Bai Jianhua , Yu Fahao , Jiang Zhaoping , Li Yue , Shang Baobing , Yan Maosen 
Published: March 2021

Abstract
There is abundant heavy oil resource in Bohai Oilfield and steam stimulation has proven an effective method through several field pilots. Till now, all steam stimulation is conducted by two-trips string for steam injection and oil production individually. That is, when the process of steam injection, soaking and blowout is finished, an oil production string will replace the downhole string through workover operation. According to statistics, the operating charge in one huff-and-puff cycle is more than 2.5 million Yuan. Besides, workover operation takes more than 26 days and results in about 1000 m3 kill fluid leak, which greatly reduce the thermal recovery effect.
Considering the drawbacks of two-trips string technology, a new injection-production integrated technology by jet pump, namely single-trip string realizing steam injection and oil production, is developed, which includes downhole string system and surface technological process system. The downhole string provides passages for steam injection and oil production. The temperature and pressure resistance of string system could reach as high as 350°C and 35MPa, respectively, which can adapt to the high temperature environment during steam injecting. The surface technological process system can separate 279m3/d producing fluid and supercharge the power fluid as high as 25MPa, which meet the needs of thermal well production.
The new technology tested in X well. More than 6000 m3 steam with 356°C temperature and 16MPa pressure was injected. The downhole string system and Christmas tree withstood the HTHP test and kept in good condition. During oil production, the surface technological process ran run steadily. The pressure of plunger pump was up to 20MPa and more than 120m3 produced fluids were separated by the separator. Compared with two-trips string technology, the new technology saved 2 million Yuan and 21 operating days. Besides, no kill fluid leaked, which improves thermal recovery effect.
This is the first time that injection-production integrated technology for steam stimulation is developed and put into field trial. The favorable application result indicates that this technology will promote the high-efficient exploitation of heavy oil in Bohai Bay.