bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Magnetoelectric Coupling of Metglas and P(VDF-TrFE) Laminates
Authors: Staaf Henrik , Sawatdee Anurak , Rusu Cristina , Nilsson David , Schäffner Philipp , Johansson Christer 
Published: September 2021

Abstract
Magnetoelectric (magnetic/piezoelectric) heterostructures bring new functionalities to develop novel transducer devices such as (wireless) sensors or energy harvesters and thus have been attracting research interest in the last years. We have studied the magnetoelectric coupling between Metglas films (2826MB) and poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) in a laminate structure. The metallic Metglas film itself served as bottom electrode and as top electrode we used an electrically conductive polymer, poly(3,4-ethylene-dioxythiophene): poly(styrene sulfonate) (PEDOT:PSS). Besides a direct electrical wiring via a graphite ink, a novel contactless readout method is presented using a capacitive coupling between the PEDOT: PSS layer and an electrode not in contact with the PEDOT:PSS layer. From the experimental result we determined a magnetoelectric coupling of 1445 V/(cm×Oe) at the magnetoelastic resonance of the structure, which is among the highest reported values for laminate structures of a magnetostrictive and a piezoelectric polymer layer. With the noncontact readout method, a magnetoelectric coupling of about 950 V/(cm×Oe) could be achieved, which surpasses previously reported values for the case of direct sample contacting. 2D laser Doppler vibrometer measurements in combination with FE simulations were applied to reveal the complex vibration pattern resulting in the strong resonant response.
Analysis of Related Factors Influencing the Efficacy of Extracorporeal Shockwave in the Treatment of Fracture Nonunion: A Prospective Study in Shanghai, China
Authors: Li Ang , Wang Rui , Yu Shiyang , Huang Jinghuan , Jiang Lixin , Li Xiaolin 
Published: September 2021

Abstract
Background: Extracorporeal shockwave is recommended as the first choice for the treatment of fracture nonunion, However, some patients with fracture nonunion have poor response to extracorporeal shockwave therapy. The present study aimed to investigate related factors which may affect the clinical efficacy of extracorporeal shockwave on fracture nonunion. Methods: Ultrasound examination was applied to observe nonunion gap, local blood supply, hardness of callus and hematoma formation before and after extracorporeal shockwave therapy. The patient's condition was followed up for 12 months after extracorporeal shockwave therapy. Four correlations and regression analysis methods were applied to analyze the factors which were correlated the clinical efficacy of extracorporeal shockwave. Receiver-operating characteristic analysis revealed that the cut-off of the fracture nonunion gap was 4.200 mm and the cut-off of the hardness of callus/impulse energy was 2.555. Single factor linear correlation analysis, multi-factor linear regression analysis, single-factor logistic regression analysis were applied. Results: The four ultrasound signs were significantly correlated with extracorporeal shockwave therapy: nonunion gap (r = -0.723; OR = 3.074), local blood supply (r = 0.611; OR = 0.191), hardness of callus/impulse energy (r = -0.510; OR = 19.942), and hematoma formation (r = 0.722; OR = 0.015). Conclusions: Nonunion gap larger than 4.200 mm and hardness of callus/impulse energy larger than 2.555 are risk factors of extracorporeal shockwave therapy outcome, and good local blood supply and effective hematoma formation induced by extracorporeal shockwave therapy are protective factors. By analyzing the related factors of extracorporeal shockwave therapy on fracture nonunion, clinicians may screen out the patients with fracture nonunion who are not suitable for extracorporeal shockwave therapy, and reduce the risk of fracture nonunion.
Comparison of cross-sectional area and fat infiltration of suboccipital muscles between normal dogs and dogs with atlantoaxial instability
Authors: Lee Namsoon , Yun Munsu , Yoon Junghee 
Published: September 2021

Abstract
Background
Atlantoaxial instability (AAI) is primarily a congenital neurological disorder affecting young toy-breed dogs. So far, most studies have focused on bones and ligaments related to AAI, and there are no studies on the suboccipital muscles (SOMs) that occupy a large area from the occipital bone to C2 in dogs. This study evaluated the cross-sectional area (CSA) and fat infiltration of the SOMs using magnetic resonance imaging (MRI), specifically, T1-weighted images, in normal dogs (≤ 5 kg) and AAI dogs. The relationship between the severity of the neurological symptoms of AAI (group A and group B) and the values from MRI was also assessed.
Results
AAI dogs had significantly smaller CSA (P = 0.029) and greater fat infiltration (P = 0.044) of the SOMs compared to normal dogs. AAI dogs with mild neurological symptoms for a long period (group A) had greater fat infiltration than AAI dogs with severe neurological symptoms (group B) (P = 0.035).
Conclusions
The muscle changes are most likely due to spinal cord compression resulting from instability; however, the possibility that chronic changes of the muscle may play an additional role in maintaining stability in this region cannot be excluded. This study provides fundamental quantitative information of the SOMs in normal and AAI dogs.
Numerical Assessment of Coastal Multi-hazard Vulnerability in Tokyo Bay
Authors: Liu Fei , Chen Jundong , Wang Yulong 
Published: September 2021

Abstract
Many bays in the world are threatened by coastal hazards such as storm surge, river flood and tsunami. Since most of the existing studies have been focused on one or two of them, in this study, the assessment of coastal vulnerability caused by the three hazards was the research target. Inundation simulation is a widely used and straightforward way in coastal vulnerability assessments; however, it is computationally expensive, and considering an increase in the number of cases in multi-hazard analysis, an efficient method was proposed using an estimated overflow volume without computing inundation, which was validated by comparing with inundation simulation. It shows that when free overflow is dominant, this method is consistent with inundation simulation approach. Using Tokyo Bay as a study area, the efficient method was then applied to multi-hazard vulnerability assessment. By comparing the overflow volume maps and maximum anomaly distribution along the coasts for four types of hazards (worst storm surge; worst concurrent storm surge and river flood; worst concurrent storm surge, river flood and Tokai-Tonankai earthquake tsunami; worst concurrent storm surge, river flood and Tokyo inland earthquake tsunami), we investigated the characteristics of different types of hazards and identified the difference between single hazard and multi-hazards. The characteristic of overflow volume along the coasts is similar to that of maximum anomaly distribution, especially for only storm surge case, the multi-hazard case combining storm surge and river flood, and the multi-hazard case combining storm surge, Tokyo inland earthquake tsunami and river flood. However, for multi-hazard case combining storm surge, Tokai-Tonankai earthquake tsunami and river flood, only by the maximum anomaly distribution, it cannot reflect the real overflow volume condition. For only storm surge case and multi-hazard case combining storm surge and river flood, the head of the bay suffers the highest vulnerability while for multi-hazard cases combining storms surge, tsunami and river flood, the difference of vulnerability in the north and south of the bay is not significant. The difference of superposing method and concurrent method for computing multi-hazards was also compared. It was found that the linear superposing method tends to overestimate the total water elevation in coastal region; however, in the coasts where superposing method underestimates the multi-hazard anomalies, upgrading dikes needs to be considered by policymakers.
TLR7/8-Agonist-Loaded M1-Macrophage-Derived Nanovesicles Promote the Polarization of Macrophages to Enhance Bladder Cancer Immunotherapy
Authors: Zhang Qing , Lin Tingsheng , Zhang Wenlong , Ding Yuanzhen , Wang Xiaofeng , Lu Wenfeng , Cao Wenmin , Wang Tingzheng , Chen Wei , Guo Hongqian 
Published: September 2021

Abstract
Immune checkpoint inhibitors (ICIs), such as PD-1/PD-L1 antibodies, modulate the cancer killing function of immune cells in the tumor microenvironment (TME). However, immunosuppressive M2-type tumor-associated macrophages (TAMs) are abundant in bladder cancer (BC) and able to release substances such as cytokines to promote tumor growth, evade immune cell attack and lead to tumor ICIs treatment resistance. In the present study, we utilized nanovesicles derived from M1 macrophages, which contained constituents of M1 macrophages (M1 NV), and loaded the vesicles with the TLR7/8 agonist R848, a potent driver of M1 macrophages to construct M1 NV-R848 nanovesicles. Compared with M1 NV or R848 treatment alone, M1 NV-R848 was able to induce polarization of M2 macrophages into M1 macrophages more efficient both in vitro and in vivo. Intravenous injection of M1 NV-R848 improved the immunosuppressive TME and inhibited tumor growth and no significantly toxic or immunogenic in MB-49 tumor-bearing mice. In addition, compared with M1 NV-R848 treatment alone, combined injection of M1 NV-R848 and PD-L1 was able to further inhibit MB-49 tumor growth. Thus, our study demonstrates that M1 NV-R848 has the ability to promote the polarization of M2 TAMs to M1 macrophages and to enhance the efficacy of the ICIs PD-L1 in the treatment of UBC with no significantly toxic or immunogenic.
An In-vitro evaluation of a polyherbal formulation, against SARS-CoV-2
Authors: Kanchibhotla Divya , Subramanian Saumya , Reddy Ravi , K.R. Hari Venkatesh , Pathania Monika 
Published: September 2021

Abstract
Background: COVID-19, caused by SARS-CoV-2 is one of the major health crisis that has affected the world in the past century. With the emergence of new strains of viruses and antimicrobial resistance, the world is looking for an alternate therapeutic option to fight infectious disease.Objective: The present study evaluated the efficacy of a novel polyherbal formulation, named NOQ19, against SARS-CoV-2 in an in vitro setting. NOQ 19 is an unique blend of 13 Ayurvedic herbs.Methodology: Vero E6 (CL1008), the African green monkey kidney epithelial cell, were infected with SARS-CoV-2 virus (isolate USA-WA1/2020) in a 96 well-plate. NOQ19 test material was diluted in different concentration as follows 0.05mg/ml, 0.1mg/ml, 0.2mg/ml, 0.3mg/ml, 0.4mg/ml, 0.5mg/ml, 0.6mg/ml, 0.7mg/ml, 0.8mg/ml and 0.9mg/ml. These different concentrations of NOQ19 were added to infected cells respectively and incubated for 3 days in 5% CO2 incubator. Remdesivir was used as a positive control.The cells were finally fixed with formaldehyde, stained with crystal violet and plaques were visualized. The number of plaques were counted to determine the PFU(plaque forming units)/mL.Results: Results demonstrated 100% antiviral efficacy of NOQ19 at 0.9mg/ml concentration with complete elimination of the virus. The IC50 of the drug was found to be 0.2mg/ml. The results of the present study demonstrated viral load reduction in SARS- CoV-2 infected Vero E6 cell lines.Conclusion: The result along with clinical trials could propose NOQ19 as a potential therapeutic option in the fighting the COVID-19 challenge.
Transcatheter Closure of Anastomotic Leakage of Aortic Root after Aortic Surgery for Type A Dissection: Two Case Reports
Authors: Song Lin , Zhang Yiran , Zhou Binyu , Zheng Xiaozhou , Shi Peixuan , Wang Haiyan 
Published: September 2021

Abstract
Background: Anastomotic leakage of postoperative aortic dissection is an intractable complication with different clinical manifestations. It is important to detect and manage anastomotic leakage in a timely manner. This case report describes 2 patients who were admitted to the hospital with different clinical manifestations and were diagnosed with aortic root anastomotic leakage through imaging. Both patients received transcatheter closure treatment with definite early effects.Case presentation: Two middle-aged women with aortic root anastomotic leakage who were admitted with different clinical manifestations and received transcatheter closure.Conclusion: Paying attention to the clinical manifestations and imaging diagnosis of patients after aortic dissection surgery is important for early detection of disease progression. Transcatheter closure can be used as an alternative treatment who cannot tolerate secondary thoracotomy due to its small trauma and exact efficacy in the near and medium terms, but further follow-up is needed for long-term clinical outcomes.
Performance and Cost Assessment of a Small Solar Photovoltaic System Using Gumbel-Haugaard Family Copula Analysis
Authors: Maihulla Anas , Yusuf Ibrahim , Bala Saminu 
Published: September 2021

Abstract
The main objective of the present study is to analyze the availability of solar photovoltaic system. The solar photovoltaic system in this paper is simple one consisting of four subsystems namely, solar panel subsystem, charge controller subsystem, batteries subsystem and inverter subsystem. Through the schematic diagram of state of the system, availability model is formulated and Chapmen - Kolmogorov differential equations are developed and solved using Gumbel Haugaard family Copula technique. The numerical values for availability, reliability, mean time to failure (MTTF), cost analysis as well as sensitivity analysis are presented. The effects of failure rates to various solar photovoltaic subsystems were developed.
Biological Modification of Pentosans in Wheat B Starch Wastewater and Preparation of a Composite Film
Authors: Li Piwu , Zhao Fei , Wei Xiaofeng , Tao Xiangling , Ding Feng 
Published: September 2021

Abstract
Background: Petrochemical resources are becoming increasingly scarce, and petroleum-based plastic materials adversely impact the environment. Thus, an urgent need exists to replace petroleum-based materials with new and effective renewable materials.Results: In this study, we isolated a wheat pentosan-degrading bacterium (MXT-1) from wheat-processing plant wastewater. The MXT-1 strain was identified using molecular biology techniques. We then analyzed the degradation characteristics of the bacteria in wheat pentosan. We found that wheat pentosan was effectively degraded by bacteria. The molecular weight of fermented wheat pentosan decreased from 1730 to 257 kDa. The pentosan before and after the biological modification was mixed with chitosan to prepare a composite film. After fermentation, the water-vapor permeability of the wheat pentosan film decreased from 0.2769 g·mm·(m2·h·KPa)-1 to 0.1286 g·mm·(m2·h·KPa)-1. The smooth and dense surface morphologies of the film was observed by scanning electron microscopy after fermentation. The tensile strength of the film decreased after fermentation modification, whereas the flexibility increased.Conclusion: The results of this study have proved that the modified pentosan film could be a potential candidate for edible packaging films.
Knowledge and preparedness for home-based, family-centered management of COVID-19 patients and dead bodies among residents in a COVID-19 high-risk setting
Authors: Kiyimba Blaise , Onyait Teddy , Kamoga Livingstone , Atuhaire Arnold , Ssekatono Patrick , Mujawamariya Lucy , Olum Ronald , Bongomin Felix , Kiguli Sarah 
Published: September 2021

Abstract
Background

The overwhelming coronavirus disease- 2019 (COVID-19) cases have called for inevitable home-based care for some cases and direct involvement in COVID-19 dead body burials by many families worldwide. However, data on the knowledge and readiness by families for these practices is still scarce, hence this study among residents of Wakiso district, Uganda.
Methods

We conducted a cross-sectional study between 6th March and 4th April 2021. Household heads aged 15years and above in 5 sub counties of Wakiso district were interviewed using a pre-tested questionnaire. Multivariable logistic regression analysis was used to assess the association between COVID-19 related knowledge on home-based care and burials with demographics characteristics.
Results

We enrolled 205 participants, with a median age of 28 (range: 25–35) years. Majority (n = 157, 76.6%) were female and had achieved at least secondary level of education (n = 117, 57.1%). The mean knowledge score on home-based care for COVID-19 patient was 49.5 %, while that on COVID-19 dead body management was 36.5%. Seven (3.4%) respondents were ready to undertake home-based care and dead body management. For the remainder 198 (96.6%) unready respondents reported inadequate knowledge (n = 166, 84%) and lack of personal protective equipment (PPE) (n = 17, 8.6%) as major barriers for their readiness. There was no statistically significant difference in both the knowledge on home-based COVID-19 patient care and dead body management stratified by demographics characteristics.
Conclusion

The knowledge and preparedness for home-based Covid-19 patient care and dead body management are suboptimal among Wakiso district residents. More public education programmes and PPE provision are recommended.
Impact of WIUT Library activities on labour market outcome
Authors: Utkirov Abbos , Salahodjaev Rauf 
Published: September 2021

Abstract
Purpose – This paper investigates the impact of the Learning Resource Centre activities of Westminster International University Tashkent (WIUT) graduated students on the labour market outcome. WIUT library provides a learning environment that helps students create functional teams and individual projects to support employability. The study aims to clarify the relationship between library activities and labour market outcomes. It proposes an employability guide to improve a commercial responsiveness workshop in collaboration with other services and alumni voices.Design/methodology/approach – A quantitative research approach was employed; an online survey questionnaire was distributed to alumni students to obtain the data. It was a semi-structured questionnaire designed using a Likert Scale to collect data from 607 graduates.Findings – The study revealed that LRC activities have a significant impact on labour market outcomes for students. LRC activities such as presentation skills, information technology skills, problem-solving skills, research skills were expected mainly by the labour market.Research limitations – The study was focused only on graduates of WIUT, which may limit the generalizability. Therefore, the researcher proposed to study and compare other graduates of universities in Uzbekistan.Practical implications – The insights are valuable for planning the curriculum of LRC activities and developing teaching practices at WIUT. Moreover, current and graduate students can learn market-oriented skills and labour market demands.Originality/value – This is the first-ever study in Uzbekistan that explores the relationship of university library activities on the employability skills of alumni.
Bibliometric Analysis of Dental Erosion (2011–2020)
Authors: Marqués Laura , Borrell Carla , Guinot Clara , Boo Paula , García Esther 
Published: September 2021

Abstract
Background: Dental erosion is a disease that causes an irreversible loss of the dental hard tissue due to acids without the involvement of bacteria. During the past decade a rising tendency of the studies about dental erosion has been observed. Objectives: The aim of the present study was to describe the current trends in published scientific articles related to dental erosion between 2011-2020. Data of the authors, year and language of publication were analyzed.Material and methods: A bibliometric analysis of the articles published in Pubmed was conducted using the terms TS (dental erosion) and TS (tooth erosion) using Boolean operator AND. A sample of n=1090 articles published during the past ten years (2011-2020) was obtained. The variables analyzed were the language of the article, the year of publishing, the number of authors, the affiliations of the first and last author and the relationship between them. Results: The ranking of countries of origin of the first and last author according to the number of publications, led by Brazil, UK, and USA. When analyzing the type of article, it is observed that 79,4% of all publications belong respond to research articles. Conclusions: The main findings in this article will help to analyze the scientific results related to dental erosion, to evaluate the management strategies needed and to identify relevant issues which need to be addressed that will lead to future studies. Keywords: Bibliometric, Citation analysis, Almetrics, dental erosion, tooth erosion.
Effects of H19/SAHH/DNMT1 on the oxidative DNA damage related to Benzo[a]pyrene exposure
Authors: Fu Ye , Li Xuejing , Pan Baolong , Niu Yingying , Zhang Bin , Zhao Xinyu , Nie Jisheng , Yang Jin 
Published: September 2021

Abstract
Background: The mechanisms that long noncoding RNA (lncRNA) H19 binding to S-adenosylhomocysteine hydrolase (SAHH) interacted with DNA methyltransferase 1 (DNMT1) and then regulated DNA damage caused by PAHs remain unclear. Results: We documented that urinary 1-hydroxypyrene (1-OHP) levels were positively associated with blood H19 RNA expression (OR: 1.51, 95% CI: 1.03 - 2.19), but opposite to plasma SAHH activity (OR: 0.63, 95% CI: 0.41 - 0.98) in coke oven workers. Moreover, by constructing various BEAS-2B cell models exposed to Benzo[a]pyrene (BaP), we investigated that H19 binding to SAHH exaggerated DNMT1 expressions and activity. Suppression of H19 enhanced the interaction of SAHH and DNMT1 in BaP-treated cells, decreased OGG1 methylation, reduced oxidative DNA damage and lessened S phase arrest. However, SAHH or DNMT1 single knockdown and SAHH/DNMT1 double knockdown showed the opposite trend. Conclusions: A H19/SAHH/DNMT1 axis was involved in OGG1 methylation, oxidative DNA damage and cell cycle arrest by carcinogen BaP.
An overview of vaginal infections’ etiologies in south-eastern Gabon
Authors: bignoumba michelle , MOGHOA Kelly MBOMBE , MUANDZE-NZAMBE Jean Ulrich , KASSA Roland Fabrice KASSA , NDZIME Yann MOUANGA , GAFOU Amahani , PENDY Neil Michel LONGO , ONANGA Richard , KUMULUNGUI Brice Serge 
Published: September 2021

Abstract
Discomfort in women of childbearing age associated with vaginal infections, namely Bacterial Vaginosis (BV), Aerobic Vaginitis (AV), VulVovaginal Candidiasis (VVC), and Trichomoniasis (TV), represent a serious and ongoing gynecological complication throughout the world. This study aimed to investigate the etiologies of vaginal infections among outpatients in south-eastern Gabon. A cross-sectional study was designed using participants referred directly by their treating doctor for a vaginal swab. Socio-demographic data were collected using a structured questionnaire. Microscopic examinations were used for TV and BV diagnostic. All vaginal swabs were cultured for AV and VVC isolates using standard microbiology methods. A total of 573 women of reproductive age participated in the study. The most common identified vaginal infections were BV (62.8%) and AV (51.1%) followed by VVC (34.1%). No significant difference was observed for each etiology compared to socio-demographic data. Streptococcus B (23.9%), Staphyloccocus aureus (17.7%), Klebsiella spp. (11.6%), and E. coli (5.8%) were the bacteria most associated with AV. A high incidence of Non-C. Albicans Candida (NCAC) strains causing vulvovaginitis were found. The prevalence of TV (2.1%) was low. Mixed infections had been common among participants. No association was found with TV and other vaginal infections, unlike others studies. The present study identified BV 228 (83.5%) and AV 227 (83.2%) as the main cause of mixed infections. The mixed infection AV-BV 113 (41.4%) was the most represented. Also, that simultaneous AV-BV-VVC represented 69 (25.3%) of mixed infections. Molecular analyses would be needed to identify the key species commonly associated with these vaginal infections.