bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between cannabis use and IVF outcome—a cohort study
Authors: Har-Gil Eden , Heled Ayala , Dixon Marjorie , Ahamed Abdul Munaf Sultan , Bentov Yaakov 
Published: September 2021

Abstract
Background
The effects of cannabis use on male and female reproduction have been the focus of scientific research for decades. Although initial studies raised concerns, more recent studies were reassuring. Considering the recent legalization of recreational use of cannabis in Canada, we sought to analyze IVF outcomes among users and non-users in a single IVF center.

Methods
This is a retrospective cohort study from a single IVF center assessing IVF outcomes among male-female, non-donor IVF patients that are either cannabis users or non-users. We analyzed the ongoing pregnancy rate as well as oocyte yield, fertilization rate, peak serum estradiol, sperm, and embryo quality. We used the Mann-Whitney test, chi-square test, and Kruskal-Wallis tests where appropriate.

Results
Overall, the study included 722 patients of which 68 (9.4%) were cannabis users, most defined as light users. The results of the study show similar implantation rate (40.74% vs. 41.13%) and ongoing pregnancy rate (35.2% vs. 29.1%) between the users and non-users, respectively. No significant difference between users and non-users in any of the other analyzed outcomes could be detected.

Conclusions
The results may provide some reassurance for the lack of any demonstrable detrimental effects of cannabis consumption on IVF outcomes. This study was limited by its retrospective nature, self-reporting of cannabis use, and a small user sample size. A larger prospective study is needed to validate its findings.
An assessment framework for safeguarding public values on mobility platforms
Authors: Riemens Rianne , Nast Carolin , Pelzer Peter , van den Hurk Martijn 
Published: September 2021

AbstractUrbanites increasingly turn to digital mobility platforms to make use of means of transportation and to plan and book journeys. While these platforms can contribute to making urban travel more sustainable and efficient, they can also lead to governance challenges and have negative external effects, raising questions about how public values can best be safeguarded. In this article, public values are defined as normative concepts that describe both the impact on and democratic control of an affected public. This article aims to initiate a more structured discussion about platform urbanism, specifically how and to what extent public values are incorporated in platform design and operation in the realm of mobility. It introduces an assessment framework for mobility platforms that was developed as part of a transdisciplinary research project in the Netherlands. This framework is grounded in two academic debates regarding 1) the rise of platform urbanism and 2) new forms of mobility that accompany the densification of cities. The paper refers to the mobility pilots Kutsuplus, UbiGo and Whim to illustrate how the safeguarding of public values can be evaluated. In the concluding section, the paper discusses some ways in which the assessment framework can be used for future research, for instance through scenarios.
Employee motivation and job performance: a study of basic school teachers in Ghana
Authors: Forson Joseph Ato , Ofosu-Dwamena Eric , Opoku Rosemary Afrakomah , Adjavon Samuel Evergreen 
Published: September 2021

AbstractMotivation as a meaningful construct is a desire to satisfy a certain want and is a central pillar at the workplace. Thus, motivating employees adequately is a challenge as it has what it takes to define employee satisfaction at the workplace. In this study, we examine the relationship between job motivation factors and performance among teachers of basic schools in Ghana. The study employs a quantitative approach on a sample of 254 teachers from a population of 678 in the Effutu Municipality of Ghana, of which 159 questionnaires were duly answered and returned (representing 62.6% return rate). Using multiple regression and ANOVA, the study finds compensation package, job design and environment and performance management system as significant factors in determining teacher’s motivation in the municipality. Thus, these motivation factors were significant predictors on performance when regressed at a decomposed and aggregated levels. These findings support the self-determination theory, more specifically on the explanations advanced under the controlled and autonomous motivation factors. Significant differences were also observed in teachers’ performance among one of the age cohorts. The study urges the municipal directorate of education to make more room for young teacher trainees and interns who are at the formative stage of their careers to be engaged to augment the experienced staff strength. More should be done to make the profession attain some level of autonomy in the discharge of duty to breed the next genre of innovative educators in the municipality.
Should high-flow through nasal cannula be used during bronchoscopy in critically ill patients with hypoxemic acute respiratory failure?
Authors: Longhini Federico , Bruni Andrea , Saraco Giuseppe , Garofalo Eugenio , Conti Giorgio 
Published: September 2021

AbstractFlexible fiberoptic bronchoscopy (FOB) is an invasive procedure with diagnostic and/or therapeutic purposes commonly used in critically ill patients. FOB may be complicated by desaturation, onset or worsening of the respiratory failure, and hemodynamic instability due to cardio-respiratory alterations occurring during the procedure. Increasing evidences suggest the use of high-flow through nasal cannula (HFNC) over conventional oxygen therapy (COT) in critically ill patients with acute respiratory failure (ARF). Indeed, HFNC has a rationale and possible physiologic advantages, even during FOB. However, to date, evidences in favor of HFNC over COT or continuous positive airway pressure (CPAP) or non-invasive ventilation (NIV) during FOB are still weak. Nonetheless, in critically ill patients with hypoxemic ARF, the choice of the oxygenation strategy during a FOB is challenging. Based on a review of the literature, HFNC may be preferred over COT in patients with mild to moderate hypoxemic ARF, without cardiac failure or hemodynamic instability. On the opposite, in critically ill patients with more severe hypoxemic ARF or in the presence of cardiac failure or hemodynamic instability, CPAP or NIV, applied with specifically designed interfaces, may be preferred over HFNC.
Ceralasertib-Mediated ATR Inhibition Combined With Olaparib in Advanced Cancers Harboring DNA Damage Response and Repair Alterations (Olaparib Combinations)
Authors: Mahdi Haider , Hafez Navid , Doroshow Deborah , Sohal Davendra , Keedy Vickie , Do Khanh T. , LoRusso Patricia , Jürgensmeier Juliane , Avedissian Manuel , Sklar Jeffrey , Glover Colin , Felicetti Brunella , Dean Emma , Mortimer Peter , Shapiro Geoffrey I. , Eder Joseph Paul 
Published: September 2021

PURPOSE Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as promising therapy in cancers with homologous recombination repair deficiency. However, efficacy is limited by both intrinsic and acquired resistance. The Olaparib Combinations basket trial explored olaparib alone and in combination with other homologous recombination–directed targeted therapies. Here, we report the results of the arm in which olaparib was combined with the orally bioavailable ataxia telangiectasia and RAD3-related inhibitor ceralasertib in patients with relapsed or refractory cancers harboring DNA damage response and repair alterations, including patients with BRCA-mutated PARP inhibitor–resistant high-grade serous ovarian cancer (HGSOC). PATIENTS AND METHODS Germline and somatic mutations had to be deleterious by COSMIC or ClinVar for eligibility. Olaparib was administered at 300 mg twice daily and ceralasertib at 160 mg daily on days 1-7 in 28-day cycles until progression or unacceptable toxicities. Primary end points were confirmed complete response (CR) or partial response (PR) rates and clinical benefit rate (CBR; CR + PR + stable disease [SD] at 16 weeks). RESULTS Twenty-five patients were enrolled, with median four prior therapies. Five patients required dose reductions for myelosuppression. Overall response rate was 8.3% and CBR was 62.5% among the entire cohort. Two of five patients with tumor harboring ATM mutation achieved CR or SD ongoing at 24+ months, respectively (CBR 40%). Of seven patients with PARP inhibitor–resistant HGSOC, one achieved PR (–90%) and five had SD ranging 16-72 weeks (CBR 86%). CONCLUSION Olaparib with ceralasertib demonstrated preliminary activity in ATM-mutated tumors and in PARP inhibitor–resistant BRCA1/2–mutated HGSOC. These data warrant additional studies to further confirm activity in these settings.
Reduced Sensitivity to Thyroid Hormone Is Associated with Diabetes and Hypertension
Authors: Mehran Ladan , Delbari Negar , Amouzegar Atieh , Hasheminia Mitra , Tohidi Maryam , Azizi Fereidoun 
Published: September 2021

Abstract

Context
Recently, reduced sensitivity to thyroid hormone as a more common finding in the general population and its possible association with metabolic parameters has been the focus of attention.

Objective
The objective was to evaluate the cross-sectional association of thyroid hormone sensitivity with diabetes, metabolic syndrome (MetS), and its components.

Methods
The study included a Tehranian representative sample of 5124 subjects aged ≥20 years participating in the Tehran Thyroid Study (2008-2011). Body weight, waist circumference, and blood pressure (BP) were measured, and serum concentrations of lipids and lipoproteins, fasting blood glucose, insulin, free thyroxine (fT4), and thyrotropin (TSH) were assayed. Thyroid hormone resistance was calculated by the Thyroid Feedback Quantile-based Index (TFQI) and Iranian-referenced Parametric TFQI (PTFQI) and compared with 2 other indices: Thyrotroph T4 Resistance Index (TT4RI) and TSH Index.

Results
TFQI was significantly associated with high BP MetS criterion (OR = 1.14, 95% CI: 1.06, 1.23) and diabetes mellitus (OR = 1.16, 95% CI: 1.04, 1. 30, P = .009) in euthyroid subjects after adjusting for age, sex, smoking, physical activity, body mass index, and Homeostasis Model Assessment Index for Insulin Resistance. TFQI was not associated with new-onset diabetes contrary to known diabetes in subgroup analysis. The results were similar for PTFQI. TSHI (OR = 1.22, 95% CI: 1.08, 1.38, P = .001) and TT4RI (OR = 1.08, 95% CI: 1.01, 1.16, P &lt; .001) were associated only with high BP in euthyroid subjects.

Conclusion
The new TFQI index seems to be the indicator of reduced sensitivity to thyroid hormone most suitable to associate its population variations with diabetes and hypertension in euthyroid subjects; however, interpretation for diabetes should be concerned with cautions, necessitating future studies.
Nonalcoholic Fatty Liver Disease in Women and Girls With Polycystic Ovary Syndrome
Authors: Falzarano Claire , Lofton Taylor , Osei-Ntansah Adjoa , Oliver Trinitee , Southward Taylor , Stewart Salim , Andrisse Stanley 
Published: September 2021

AbstractContextNonalcoholic fatty liver disease (NAFLD) describes a spectrum of liver damage due to excessive hepatic lipid accumulation. Recent research has demonstrated a high prevalence of NAFLD in women with polycystic ovary syndrome (PCOS).ResultsStrong associations independent of body mass index (BMI) have been found between high androgen levels characteristic of PCOS, as well as insulin resistance, and the presence of NAFLD in these women, suggesting that these factors contribute to liver injury more significantly than obesity. Current studies indicate the occurrence of NAFLD in normal weight women with PCOS in addition to the commonly researched women who are overweight and obese. While the majority of studies address NAFLD in adult, premenopausal women (ages 25-40 years), the occurrence of NAFLD in young and adolescent women has gone largely unaddressed. Research in this field lacks diversity; a majority of studies either focus on populations of White women or are missing demographic information entirely.ConclusionsFuture studies should include larger, more racially and ethnically inclusive populations and particular attention should be paid to how excess androgens and insulin resistance contribute to the increased risk of NAFLD seen in women with PCOS of varying weights, ages, and ethnicities.Objective and MethodsHere, we review NAFLD in women with PCOS with subsections focused on the impact of hyperandrogenism, BMI, insulin resistance and age. Most notably, we present the most up-to-date racially and ethnically diverse worldwide prevalence of NAFLD in women with PCOS compared with women without PCOS (51.56% vs 29.64%, P &lt; .001, respectively).
Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus
Authors: Jais Alexander , Brüning Jens C 
Published: September 2021

Abstract
The central nervous system (CNS) receives information from afferent neurons, circulating hormones, and absorbed nutrients and integrates this information to orchestrate the actions of the neuroendocrine and autonomic nervous systems in maintaining systemic metabolic homeostasis. Particularly the arcuate nucleus of the hypothalamus (ARC) is of pivotal importance for primary sensing of adiposity signals, such as leptin and insulin, and circulating nutrients, such as glucose. Importantly, energy state–sensing neurons in the ARC not only regulate feeding but at the same time control multiple physiological functions, such as glucose homeostasis, blood pressure, and innate immune responses. These findings have defined them as master regulators, which adapt integrative physiology to the energy state of the organism. The disruption of this fine-tuned control leads to an imbalance between energy intake and expenditure as well as deregulation of peripheral metabolism. Improving our understanding of the cellular, molecular, and functional basis of this regulatory principle in the CNS could set the stage for developing novel therapeutic strategies for the treatment of obesity and metabolic syndrome. In this review, we summarize novel insights with a particular emphasis on ARC neurocircuitries regulating food intake and glucose homeostasis and sensing factors that inform the brain of the organismal energy status.
Using pens as an incentive for questionnaire return in an orthopaedic trial: an embedded randomised controlled retention trial
Authors: Mitchell Alex S. , Cook Liz , Dean Alexandra , Fairhurst Caroline , Northgraves Matthew , Torgerson David J. , Reed Mike 
Published: September 2021

Background: We did a ‘study within a trial’ (SWAT), evaluating the effectiveness of the inclusion of a pen with a postal questionnaire, compared to no pen being included, on the retention rate in a large orthopaedic trial. Methods: The SWAT was embedded in the KReBS trial. The primary outcome was the proportion of 12-month questionnaires returned. Secondary outcomes were the proportion of questionnaires completed and time to questionnaire return. Binary data were analysed using logistic regression and time to return using Cox proportional hazards regression. Odds ratios (OR) and hazard ratios (HR) are presented, with associated 95% confidence intervals and p-values. Results: In total, 2305 participants were randomised into the SWAT. In the pen group, 1020/1145 (89.1%) of participants returned a questionnaire, compared to 982/1147 (85.6%) in the no pen group. The absolute difference in questionnaire return rate was 3.5% (95% CI: 0.8% to 6.2%; p=0.01). There were statistically significant differences in questionnaire return rate (OR 1.36; 95% CI: 1.06 to 1.74; p=0.02), questionnaire completion rate (OR 1.40; 95% CI: 1.11 to 1.78; p<0.01) and time to questionnaire return (HR 1.17; 95% CI: 1.07 to 1.27; p<0.01) favouring the pen group. Conclusion: This SWAT adds to the growing evidence base for whether pens are effective as an incentive for retention, and indicates their potential effectiveness. Registration: KReBS trial registered on 20 February 2019, ID ISRCTN87127065; SWAT registered on 1 April 2019, ID SWAT92.
Therapy for patients with asymptomatic and mild cases of COVID-19 in Indonesia
Authors: Wahyuhadi Joni , Triyono Erwin Astha , Waloejo Christijogo Soemartono , Harianto Agus , Jaya Halim Priyahau , Aulia Fauqa Arinil , Iswara Nalendra Djaya , Harianto M. Arif , Murti Krisna , Sriyono Sriyono , Kiranasari Ninis Herlina , Ali Nurarifah Destianizar , Lusida Michael Austin Pradipta , Asyari Claudia Herda , Situmorang Friedrich Rabin , Nabilah Nabilah , Arifianto Muhammad Reza , Waskito Langgeng Agung , Al Farabi Makhyan Jibril 
Published: September 2021

Background: Though coronavirus disease (COVID-19) has been designated as a global pandemic, its nature as a viral infection means that it is essentially a self-limiting disease. We studied the application of symptomatic, isolation, relaxation, nutrition and observation (SIRNO) therapy in patients with asymptomatic and mild symptoms of COVID-19 at a rescue hospital in Indonesia. Methods: This is a retrospective cohort study involving 2122 patients who were admitted to Indrapura Field Hospital in Surabaya from 28 May 2020 to 20 September 2020. We analyzed demographic data, clinical signs and symptoms, laboratory data, therapy and clinical outcomes. Result: The total sample of 2122 patients consisted of 1403 male patients (66.12%), and 719 female patients (33.88 %). The most common age range was 26-45 years, at 52.54% (1115 patients). The clinical symptoms of 1121 patients (52.8%) were asymptomatic, 977 patients (46%) had mild symptoms, and 24 patients (0.1%) had moderate symptoms. All patients received the SIRNO therapy method. From a total of 2122 patients, 1930 patients (90.9%) were cured, 181 patients (8.5%) are still being treated, seven patients (0.03%) were referred for indications of desaturation (SpO2 <94%), and four patients (0.01%) were moved to a referral hospital. Until 20 September 2020, the final date studied, there were no patient deaths. Conclusion: The SIRNO method provides excellent results in the management of COVID-19 at a rescue hospital for patients with asymptomatic and mild symptoms. Economic pharmacological research can initiate a follow-up study in order to objectively measure the effectiveness and efficiency of SIRNO treatment methods in patients with asymptomatic, mild symptoms of COVID-19, and the small number of 24 patients (0,.1%) with moderate symptoms.
Data fusion based lane departure warning framework using fuzzy logic
Authors: Ping Em Poh , Hossen J. , Kiong Wong Eng 
Published: September 2021

Background: Lane detection is a difficult issue because of different lane circumstances. It plays an important part in advanced driver assistance systems, which give information about the centre of a host vehicle such as lane structure and lane position. Lane departure warning (LDW) is used to warn the driver about an unplanned lane exit from the original lane. The objective of this study was to develop a data-fusion LDW framework to improve the rate of detection of lane departure during daylight and at night. Methods: Vision-based LDW is a comprehensive framework based on vision-based lane detection with additional lateral offset ratio computations based on the detected X12 and X22 coordinates. The computed lateral offset ratio is used to detect lane departure based on predefined LDW identification criteria for vision-based LDW. Data fusion-based LDW was developed using a multi-input-single-output fuzzy logic controller. Data fusion involved lateral offset ratio and yaw acceleration response from the vision-based LDW and model-based vehicle dynamics frameworks. Real-life datasets were generated for simulation under the MATLAB Simulink platform. Results: Experimental results showed that fusion-based LDW achieved an average lane departure detection rate of 99.96% and 98.95% with false positive rates (FPR) of 0.04% and 1.05% using road footage clips #5–#27 in daytime and night-time, respectively. The average FPR using data fusion-based LDW reduced by 18.83% and 15.22% compared to vision-based LDW in daytime and night-time, respectively. Conclusions: The data fusion-based LDW is a novel way of reducing false lane departure detection by fusing two types of modalities to determine the correct lane departure information. The limitation is the constant warning threshold value used in the current implementation of LDW in the vision-based LDW framework. An adaptive mechanism of warning threshold taking various road structures into account could be developed to improve lane departure detection.
Infertility and subsequent recurrent miscarriage: Current state of the literature and future considerations for practice and research
Authors: Linehan Laura , Hennessy Marita , O'Donoghue Keelin 
Published: September 2021

Background: Recurrent miscarriage (RM) and infertility are independently associated with adverse pregnancy outcomes, in addition to psychological sequelae. Experiencing pregnancy loss alongside infertility is particularly difficult. International guidance regarding RM is conflicting, and applicability to women with infertility is undetermined. The aim of this study was to: (i) establish if women/couples with a history of infertility are recognised in the literature on the investigation and management of RM, and (ii) determine if the specific needs of women/couples experiencing RM and infertility are ascertained and incorporated into clinical management strategies. Methods: We examined the wide-ranging literature to ascertain what gaps existed. Studies were retrieved through searches of PubMed and Google Scholar up to 21 January 2021 using appropriate controlled vocabulary and combinations of key words. No language or study design restrictions were applied. Results: While women/couples experiencing RM after infertility appear in studies evaluating investigations and proposed treatments, high-quality studies are lacking. Furthermore, they are largely excluded from international clinical guidance and qualitative research. Conclusions: The experiences of women/couples with RM and infertility and their specific care needs within maternity and fertility services are underexplored. It is unclear from current RM guidelines how best to manage and support this complex cohort. Women/couples with infertility and RM are underserved in the literature and in clinical guidance. Further robust studies are warranted to examine pregnancy outcomes, investigations and treatments currently used. Qualitative research is also required to identify their medical and psychological needs to better support this vulnerable group.
Speculative Trading and Bubbles: Evidence from the Art Market
Authors: Pénasse Julien , Renneboog Luc 
Published: September 2021

We argue that extrapolative expectations drive boom–bust cycles in the postwar art market. Price run-ups coincide with increases in demand fundamentals but are followed by predictable busts. Predictable changes account for about half of the variance of five-year price changes. High prices coincide with many attributes of speculative bubbles: trading volume, the share of short-term trades, the share of postwar art, and volatility are all higher during booms. In addition, short-term transactions underperform long-term transactions. Survey evidence further confirms the link between beliefs, prices, and volume dynamics as in models in which extrapolative beliefs fuel speculative bubbles. This paper was accepted by Tyler Shumway, finance.