bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Pengetahuan dengan Perilaku Kesehatan Gigi dan Mulut
Authors: Anang Anang , Robbihi Hilmiy Ila 
Published: September 2021

Abstrak Tingginya prevalensi penyakit gigi dan mulut disebabkan oleh berbagai faktor, antara lain: Â pengetahuan, sikap dan perilaku dalam memelihara kesehatan gigi yang masih rendah. Hasil survey yang dilakukan pada mahasiswa baru jurusan Keperawatan Gigi, diperoleh sebanyak 30 orang memiliki penyakit gingivitis. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan dengan perilaku kesehatan gigi dan mulut mahasiswa DIII tingkat 1 jurusan Keperawatan Poltekkes Kemenkes Tasikmlaya tahun akademik 2019/2020. Jenis penelitian yang digunakan adalah deskriptif analitik. Untuk pengujian hipotesis digunakan uji korelasi product moment untuk melihat hubungan antara variabel bebas dan terikat. Subjek dalam penelitian ini adalah seluruh mahasiswa tingkat I Diploma III Jurusan Keperawatan Poltekkes Kemenkes Tasikmalaya Tahun Akademik 2019/2020 berjumlah 79 orang. Instrumen penelitian terdiri dari angket pengetahuan dan perilaku yang dibuat dalam google form. Hasil Penelitian menunjukkan tingkat pengetahuan tentang kesehatan gigi mayoritas baik sebanyak 38 orang (51%), cukup 36 orang (49%) dan tidak ada yang termasuk kategori kurang (0). Perilaku mahasiswa tentang kesehatan gigi dan mulut mayoritas baik sebanyak 68 orang (92%), cukup 6 orang (8%) dan tidak ada yang termasuk perilaku kurang, nilai signifikansi 0,038 < 0,05 dengan demikian dapat simpulkan terdapat hubungan pengetahuan dengan perilakuÂ kesehatan gigi dan mulut.Â Kata kunci: pengetahuan, perilaku kesehatan gigi dan mulutÂ Abstract The high prevalence of oral and dental diseases is caused by various factors: knowledge, attitudes and behavior in maintaining dental health which are still low. The survey conducted on new students majoring in dental nursing showed that 30 people had gingivitis. The purpose of this study was to determine the relationship between knowledge and oral health behavior in DIII level 1 nursing students majoring in the Health Polytechnic of the Ministry of Health, Tasikmlaya in the 2019/2020 academic year. This type of research used descriptive analytic. To test the hypothesis, the product moment correlation test is used to see the relationship between the independent and dependent variables. The subjects in this study were all students of level I Diploma III Nursing Department of the Health Polytechnic of the Ministry of Health, Tasikmalaya, Academic Year 2019/2020, totaling 79 people. The research instrument consisted of a knowledge and behavior questionnaire made on by google form. The results of this study showed that the level of knowledge about dental health, the majority were good as many as 38 people (51%), 36 people in sufficient category (49%) and none were in the poor category (0). The majority in oral health were in the good category 68 people (92%), sufficient category 6 people (8%) and noone was in lacking behavior. The significance value is obtained 0.038 < 0.05, so there is a relationship between knowledge and oral health behavior.Â Keywords:Â Â Â Â Â Â Â Â Â Â Â Â Â Â knowledge, oral health behavior
Influence of Sowing Dates on the Phenological Development, Growth and Yield Of White Maize Genotypes
Authors: Akhtar S , Ullah MJ , Hamid A , Islam MS , Ahamed MKU , Masum SM 
Published: September 2021

The experiment was conducted at the Sher-e-Bangla Agricultural University (90o22 E, 23o 41 N), Dhaka, Bangladesh in Rabi (winter) season of 2017-2018 to study the effects of sowing date on growth and yield of four white maize genotypes, viz. PSC-121, Yangnuo-7, Yungnuo-30 and Changnuo-6. Sowing dates were November 26, December 11, and December 26. Data were collected on different phenological growth stages, dry matter, physiological attributes, yield, and yield attributes. A delay in sowing date delayed the time required for seedling emergence, to reach the 6-leaf collar, maturity stage, and also reduced yield. The planting of PSC-121 in November 26 gave the highest dry matter plant-1, the number of grains cob-1, and 100- grain weight that resulted in the highest grain yield (11.65 t/ha) of the genotype.
Bangladesh Agron. J. 2021, 24(1): 57-70
PENGEMBANGAN KAPASITAS (CAPACITY BUILDING) USAHA KECIL DAN MENENGAH BIDANG PERTANIAN DI KECAMATAN RANCABUNGUR KABUPATEN BOGOR
Authors: Ma’ruf Mu’min , Ikhbaluddin Ikhbaluddin , Suripto Suripto , Abdurohim Abdurohim 
Published: September 2021

Small and Medium Enterprise (Usaha Kecil dan Menengah; UKM) is the backbone of the economy of society, as this sector has accommodated more jobs compared to a large industrial sector. However, the effort of local government in empowering UKM is still not optimal. This issue has become one of the problems for developing the capacity of UKM, particularly the agricultural sector, in Rancabungur District, Bogor Regency. This research aims to describe in-depth the capacity building of this UKM based on the concept developed by UNDP by using a qualitative method with a descriptive approach. Here we highlighted three point of the capacity development: the workforce or human resource (HR), the capital (physical dimension), and the technology. The results show that there are some problems in the capacity building of the UKM’s agricultural sector, notably for its workforce capacity development and the difficulty to access the capital weather for financing or supporting the facilities and infrastructures of the UKM. Moreover, we found that the UKM has a lack of ability for its technology development, notably for its ability to access the information technology and the availability of communication network.
Keywords: Capacity Building; Small and Medium Enterprise
STRATEGI MARKETING POLITIK ADIATMA DWI PUTRA – SULKARNAIN PADA PEMILIHAN WALIKOTA KENDARI TAHUN 2017
Authors: Adam Aenal Fuad 
Published: September 2021

Penelitian ini mengungkap strategi marketing politik. Tujuannya adalah menjelaskan bagaiamana praktik marketing politik beroraperasi dalam kontestasi pilwali kota kendari. Penelitian ini menggunakan metode kualitatif. Data bersumber dari data primer dan sekunder yang kemudian dianalisis dengan mereduksi, memverifikasi dan membuat kesimpulan. Hasil penelitian ini menemukan bahwa proses segmentasi, targeting dan positioning politik menjadi strategi untuk bisa meraih simpati pemilih. Pasangan calon Adiatma Dwi Putra – Sulkarnain berfokus pada pada tiga segmen, yaitu segmen pemilih pemula/muda Adiatma Dwi Putra – Sulkarnain membangun image sebagai perwakilan anak muda, sementara pada kelompok perempuan Adiatma Dwi Putra menjual program yang memperjuangkan hak – hak dan kepentingan perempuan. Untuk warga berpendapatan rendah, Adiatma Dwi Putra – Sulkarnain menjual produk politik dengan memberikan pelayanan dan membuka lapangan usaha untuk para pemilih berpendapatan rendah.
Kata Kunci: Strategi, Marketing Politik, Pilwali
Policy Learning and Handling of Covid-19 in Indonesia
Authors: Agustino Leo 
Published: September 2021

Abstract
This article discusses the policy learning process in managing the Coronavirus Disease 2019 (COVID-19) within Indonesia and asks several questions regarding the policies formulated and implemented, as well as how the government "learns" and handles the pandemic. Furthermore, this study used a qualitative research method supported by literature discourse methods and online interviews, as well as a policy learning theory-based analysis. According to the results, the Indonesian government has learned a lot from other countries, however, the country has been rather slow in anticipating the pandemic, causing a minimal sense of crisis and urgency. In addition, the low level of trust and seriousness in the government has implications for a less harmonious relationship between the center and the regions. Also, the inter-institutional coordination and the inaccuracy of actors in handling the pandemic is an unresolved problem, therefore, the distribution location expands continually and the infection curve never slopes.
Keywords: Policy Learning; Handling; COVID-19; Policy
Circulating Vascular Adhesion Protein-1 Level Predicts the Risk of Cardiovascular Events and Mortality in Hemodialysis Patients
Authors: Kim Dae Kyu , Lee Yu Ho , Kim Jin Sug , Kim Yang Gyun , Lee So-Young , Ahn Shin Young , Lee Dong-Young , Jeong Kyung Hwan , Lee Sang-Ho , Hwang Hyeon Seok , Moon Ju-Young 
Published: September 2021

Background: Vascular adhesion protein-1 (VAP-1) is an oxidative enzyme of primary amines that facilitates the transmigration of inflammatory cells. Its oxidative and inflammatory effects are prominently increased in pathological conditions, such as metabolic, atherosclerotic, and cardiac diseases. However, the clinical significance of circulating VAP-1 levels in hemodialysis (HD) patients is unclear.Methods: A total of 434 HD patients were enrolled in a prospective multicenter cohort study between June 2016 and April 2019. Plasma VAP-1 levels were measured at the time of data entry, and the primary endpoint was defined as a composite of cardiovascular (CV) and cardiac events.Results: Circulating VAP-1 levels were positively correlated with plasma levels of cardiac remodeling markers, including brain natriuretic peptide, galectin-3, and matrix metalloproteinase-2. Multivariable logistic regression analysis revealed that patients with higher circulating VAP-1 levels were more likely to have left ventricular diastolic dysfunction [odds ratio, 1.40; 95% confidence interval [CI], 1.04–1.88]. The cumulative event rate of the composite of CV events was significantly greater in VAP-1 tertile 3 than in VAP-1 tertiles 1 and 2 (P = 0.009). Patients in tertile 3 were also associated with an increased cumulative event rate of cardiac events (P = 0.015), with a 2.06-fold higher risk each for CV (95% CI, 1.10–3.85) and cardiac (95% CI, 1.03–4.12) events after adjusting for multiple variables.Conclusions: Plasma VAP-1 levels were positively associated with left ventricular diastolic dysfunction and the risk of incident CV and cardiac events in HD patients. Our results indicate that VAP-1 may aid clinicians in identifying HD patients at a high risk of CV events.
Association Between Enterovirus Infection and Type 1 Diabetes Risk: A Meta-Analysis of 38 Case-Control Studies
Authors: Wang Kan , Ye Fei , Chen Yong , Xu Jianxin , Zhao Yufang , Wang Yeping , Lan Tian 
Published: September 2021

ObjectiveThe association between enterovirus infection and type 1 diabetes (T1D) is controversial, and this meta-analysis aimed to explore the correlation.MethodsPubMed, Embase, Web of Science, and Cochrane Database were searched from inception to April 2020. Studies were included if they could provide sufficient information to calculate odds ratios and 95% confidence intervals. All analyses were performed using STATA 15.1.ResultsThirty-eight studies, encompassing 5921 subjects (2841 T1D patients and 3080 controls), were included. The pooled analysis showed that enterovirus infection was associated with T1D (P &lt; 0.001). Enterovirus infection was correlated with T1D in the European (P &lt; 0.001), African (P = 0.002), Asian (P = 0.001), Australian (P = 0.011), and Latin American (P = 0.002) populations, but no conclusion could be reached for North America. The association between enterovirus infection and T1D was detected in blood and tissue samples (both P &lt; 0.001); no association was found in stool samples.ConclusionOur findings suggest that enterovirus infection is associated with T1D.
The Significance of MET Expression and Strategies of Targeting MET Treatment in Advanced Gastric Cancer
Authors: Liao Haiyan , Tian Tiantian , Sheng Yuling , Peng Zhi , Li Zhongwu , Wang Jingyuan , Li Yanyan , Zhang Cheng , Gao Jing 
Published: September 2021

BackgroundAccurate assessment of predictive biomarker expression is critical in patient selection in clinical trials or clinical practice. However, changes in biomarker expression may occur after treatment. The aim of the present study was to evaluate the effects of chemotherapy on MET expression in gastric cancer (GC).MethodsMET expression was examined immunohistochemically before and after treatment in 122 patients with unresectable or recurrent GC, and was evaluated according to H-score or the scoring criteria used in the MetMAb trial. MET gene amplification was assessed by chromogenic in situ hybridization (CISH). The antitumor effect of MET targeted therapy was investigated in human gastric cancer cells in vitro and in vivo, and the underlying molecular mechanisms were analyzed by western blot.ResultsMET expression was associated with Lauren classification as well as tumor differentiation by either scoring system. MET amplification was not associated with clinical characteristics. Of the 71 patients who had paired pre- and post-treatment tumor tissues, 28 patients (39%) were initially positive for MET expression, and 43 (61%) were negative. Twenty-five patients (35%) showed significant changes in MET expression after treatment (P=0.007). Additionally, there was a concomitant overexpression of MET and HER2 in a subset of GC patients. MET inhibitor volitinib could significantly inhibit cell proliferation and xenograft growth in vitro and in vivo in MKN45 cells with MET and phosphorylated MET (pMET) high expressions via suppressing downstream PI3K/Akt and MAPK signaling pathways. Furthermore, combination therapy targeting both MET and HER2 demonstrated a synergistic antitumor activity.ConclusionsMET expression is altered post chemotherapy and MET status should be evaluated in real-time. Both MET and pMET expressions might need to be considered for patients suitable for volitinib treatment.
Comparison of Rifabutin-Based Versus Rifampin-Based Regimens for the Treatment of Mycobacterium avium Complex: A meta-Analysis Study
Authors: Hajikhani Bahareh , Nasiri Mohammad Javad , Adkinson Brian C. , Azimi Taher , Khalili Farima , Goudarzi Mehdi , Dadashi Masoud , Murthi Mukunthan , Mirsaeidi Mehdi 
Published: September 2021

Background: The incidence of Mycobacterium avium complex (MAC) increases as immunosuppressed conditions become more common. MAC's standard treatment regimen includes a macrolide, ethambutol, and a rifamycin, among which rifampin and rifabutin are the most commonly used. Although current guidelines recommend initial therapy for MAC with rifampin, it has been theorized to be less efficacious than rifabutin.Methods: We reviewed the relevant scientific literature published up to February 18, 2020. Statistical analyses were performed with Comprehensive Meta-Analysis Software Version 2.0 (Biostat, Englewood, NJ). The pooled frequency with 95% confidence intervals (CI) was assessed using a random-effect model. We considered P &lt;0.05 as statistically significant for publication bias.Results: After reviewing 3665 records, we identified 24 studies that satisfied the inclusion criteria. Among these studies, 8 had rifabutin in their regimens (rifabutin group) and 16 had rifampin in their regimens (rifampin group). The estimated pooled treatment success rate was found to be 54.7% (95% CI 41.0-67.0%) in rifabutin groups and 67.5% (95% CI 55.7-77.4%) in rifampin groups. There was no evidence of publication bias among the included studies (Egger’s test p-value was 0.7).Conclusion: In this study, it was shown that in comparison to Rifabutin, rifampin has similar treatment success rates in treating MAC. In order to determine the exact preference of each of these drugs, double-blind clinical trial studies are recommended.
The Effect of Phosphodiesterase-type 5 Inhibitors on Erectile Function: An Overview of Systematic Reviews
Authors: Pyrgidis Nikolaos , Mykoniatis Ioannis , Haidich Anna-Bettina , Tirta Maria , Talimtzi Persefoni , Kalyvianakis Dimitrios , Ouranidis Andreas , Hatzichristou Dimitrios 
Published: September 2021

Background: Multiple systematic reviews explore the effect of phosphodiesterase type 5 (PDE5) inhibitors on erectile dysfunction (ED), with each study addressing specific outcomes. However, physicians and policymakers require a holistic approach of this topic.Objective: To summarize the current evidence regarding the efficacy and safety of PDE5 inhibitors for the management of ED through an overview of systematic reviews.Methods: Studies were identified by searching PubMed, Web of Science, Cochrane Library and Scopus databases, as well as sources of grey literature until June 12, 2021 (PROSPERO: CRD42020216754). We considered systematic reviews, meta-analyses or network meta-analyses of randomized trials that provided outcomes about the efficacy and safety of any approved PDE5 inhibitor (avanafil, sildenafil, tadalafil and vardenafil). We constructed forest plots for meta-analytic effects regarding the change in erectile function, adverse events and dropouts after administration of PDE5 inhibitors in the general population and in specific patient groups.Results: We included 23 studies with 154,796 participants and a total of 258 meta-analytic effects. Sildenafil 25 mg [Weighted Mean Difference (WMD): 13.08, 95% Confidence Interval (CI): 10.1-16.06] seemed to be statistically superior to all interventions in improving erectile function compared to placebo, but studies with low-dose sildenafil are lacking. Moreover, comparing among different PDE5 inhibitors, sildenafil 50 mg or sildenafil 100 mg were considered the most effective compounds in the general population. The latter derived, however, predominantly from indirect comparisons among different PDE5 inhibitors. Still, sildenafil 100 mg was associated with more treatment-related adverse events and dropouts. Interestingly, low-dose daily tadalafil may be more effective than high-dose on-demand tadalafil (WMD: 1.24, 95% CI: 0.03-2.44). Furthermore, testosterone and PDE5 inhibitors in patients with ED and hypogonadism seem to further improve symptoms, while the addition of a-blockers in patients with urinary symptoms treated with PDE5 inhibitors does not provide additional benefits (WMD: −0.8, 95% CI: −1.65-0.06).Conclusion: Although the efficacy and safety of PDE5 inhibitors, compared to placebo, is well-documented, the existing evidence comparing different PDE5 inhibitors is low. Therefore, high-quality, head-to-head, trials comparing different PDE5 inhibitors are necessary to determine their ideal dosage and formulation based on their safety and efficacy profile.Systematic Review Registration: PROSPERO, identifier [CRD42020216754].
Identification of VCAN as Hub Gene for Diabetic Kidney Disease Immune Injury Using Integrated Bioinformatics Analysis
Authors: Xu Qiannan , Li Binjue , Wang Yucheng , Wang Cuili , Feng Shi , Xue Lu , Chen Jianghua , Jiang Hong 
Published: September 2021

Background: Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease in China. Tubular injury contributes to the progression of DKD. Our study was conducted to explore the differential gene expression profiles between kidneys from patients with DKD and kidney living donors (LDs).Methods: In total, seven DKD and eighteen LD gene expression profiles from the GSE104954 dataset were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were analyzed in R with the limma package. DEGs were uploaded to the g:Profiler online database to explore the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Ingenuity pathway analysis (IPA) was carried out using online IPA software. Weighted gene co-expression network analysis (WGCNA) was performed using the WGCNA R package. By integrating DEGs and genes from the top 1 phenotype-gene associated module, we determined the hub gene. We next tested the hub gene, VCAN, in the GSE30122 dataset. We also validated the versican levels in human kidney tissues, explored immune cell type enrichment using an online database xCell, and investigated the correlation between cell types and VCAN expression.Results: A total of 563 DEGs was identified. A large number of pathways were involved in the immune response process according to the results of GO, KEGG, and IPA. Using WGCNA, we selected the lightcyan module in which genes showed the strongest correlation with the phenotype and smallest P-value. We also identified VCAN as a hub gene by integrating DEG analysis and WGCNA. Versican expression was upregulated in human diabetic kidney tissue. Moreover, versican was speculated to play a role in immune injury according to the enrichment of functions and signaling pathways. VCAN transcript levels correlate with the assembly of immune cells in the kidney.Conclusion: Immune processes played an essential role in DKD tubulointerstitium injury. The hub gene VCAN contributed to this process.
Systematic Review of Efficacy of Interventions for Social Isolation of Older Adults
Authors: Tong Feng , Yu ChengLin , Wang LinSen , Chi Iris , Fu Fang 
Published: September 2021

Background: The social isolation of older people is a growing public health concern. The proportion of older people in society has increased in recent decades, and it is estimated that ~40% of the population will be aged 50 or above within the next few decades. This systematic review aims to summarize and renew knowledge of the effectiveness of existing interventions for alleviating social isolation of older adults.Methods: Relevant electronic databases, including Cochrane Library, CINAHL, SCOPUS, and Web of Science, were searched by a systematic evaluation method. Eligible randomized controlled trial (RCT) studies were published between 1978 and 2021 in English or Chinese. The primary and secondary outcomes were social isolation and loneliness. The quality of the included RCTs was scored by the Cochrane risk-of-bias tool to assess their quality. Two independent reviewers extracted data, using a standardized form. Narrative synthesis and vote-counting methods were used to summarize and interpret study data.Results: Twenty-four RCTs were finally included in this review. There was evidence of substantial heterogeneity in the interventions delivered. The overall quality of included studies indicated a low-to-medium risk of bias. Eighteen of 24 RCTs showed at least one dimension effect on reducing social isolation. The interventions with accurate targeting of clients in social and public places had more obvious effect. The interventions in which older people are active participants also appeared more likely to be effective. In addition, group intervention activities and individual intervention interviews were effective in improving structural social support; mixed intervention, and group intervention on training support significantly improved functional social support.Conclusions: This study suggests that group and mixed intervention targeting of older adults could be helpful for alleviating social isolation problems. The use of modern technology for remote services could also present good results. More well-conducted RCTs of the effectiveness of social interventions for alleviating social isolation are needed to improve the evidence base. Especially as the debating results of remote interventions, further research in this field should be conducted.