bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the Reliability of Passive Server Components for Single-Phase Immersion Cooling
Authors: Shah Jimil M. , Padmanaban Keerthivasan , Singh Hrishabh , Duraisamy Asokan Surya , Saini Satyam , Agonafer Dereje 
Published: September 2021

Abstract
The adoption of Single-phase Liquid Immersion Cooling (Sp-LIC) for Information Technology equipment provides an excellent cooling platform coupled with significant energy savings. There are, however, very limited studies related to the reliability of such cooling technology. The Accelerated Thermal Cycling (ATC) test given ATC JEDEC is relevant just for air cooling but there is no such standard for immersion cooling. The ASTM benchmark D3455 with some appropriate adjustments was adopted to test the material compatibility because of the air and dielectric fluid differences in the heat capacitance property and corresponding ramp rate during thermal cycling. For this study, accelerated thermal degradation of the printed circuit board (PCB), passive components, and fiber optic cables submerged in air, white mineral oil, and synthetic fluid at a hoisted temperature of 45C and 35% humidity is undertaken. This paper serves multiple purposes including designing experiments, testing and evaluating material compatibility of PCB, passive components, and optical fibers in different hydrocarbon oils for single-phase immersion cooling. Samples of different materials were immersed in different hydrocarbon oils and air and kept in an environmental chamber at 45C for a total of 288 hours. Samples were then evaluated for their mechanical and electrical properties using Dynamic Mechanical Analyzer (DMA) and a multimeter, respectively. The cross-sections of some samples were also investigated for their structural integrity using SEM. The literature gathered on the subject and quantifiable data gathered by the authors provide the primary basis for this research document.
Erratum: "Review on the dynamics of isothermal liquid bridges" [ASME Appl. Mech. Rev., 2020, 72(1): 010803; DOI: 10.1115/1.4044467]
Authors: Montanero Jose Maria , Ponce-Torres Alberto 
Published: September 2021

Abstract
We correct the equations for the surface stresses associated with the shear and dilatational surface viscosities
Comparison of Physiological Responses and Muscle Activity During Incremental and Decremental Cycling Exercise
Authors: Beltrami Fernando G. , Froyd Christian , Mauger Alexis R. , Metcalfe Alan J. , Noakes Timothy D. 
Published: September 2021

Objective: To investigate whether a cycling test based on decremental loads (DEC) could elicit higher maximal oxygen uptake () values compared with an incremental test (INC). Design: Nineteen well-trained individuals performed an INC and a DEC test on a single day, in randomized order. Methods: During INC, the load was increased by 20 W·min−1 until task failure. During DEC, the load started at 20 W higher than the peak load achieved during INC (familiarization trial) and was progressively decreased. Gas exchange and electromyography (EMG) activity (n = 11) from 4 lower-limb muscles were monitored throughout the tests. Physiological and EMG data measured at were compared between the 2 protocols using paired t tests. Results: during the DEC was 3.0% (5.9%) higher than during INC (range 94%–116%; P = .01), in spite of a lower power output (−21 [20] W, P < .001) at . Pulmonary ventilation (P = .036) and breathing rate (P = .023) were also higher during DEC. EMG activity measured at was not different between tests, despite the lower output during DEC. Conclusions: A DEC exercise test produces higher in cycling compared with an INC test, which was accompanied by higher pulmonary ventilation and similar EMG activity. The additional O2 uptake during DEC might be related to extra work performed either by the respiratory muscles and/or the less oxidatively efficient leg muscles.
Peer Presence Increases Session Ratings of Perceived Exertion
Authors: Minett Geoffrey M. , Fels-Camilleri Valentin , Bon Joshua J. , Impellizzeri Franco M. , Borg David N. 
Published: September 2021

Purpose: This study aimed to examine the effect of peer presence on session rating of perceived exertion (RPE) responses. Method: Fourteen males, with mean (SD) age 22.4 (3.9) years, peak oxygen uptake 48.0 (6.6) mL·kg−1·min−1, and peak power output 330 (44) W, completed an incremental cycling test and 3 identical experimental sessions, in groups of 4 or 5. Experimental sessions involved 24 minutes of cycling, whereby the work rate alternated between 40% and 70% peak power output every 3 minutes. During cycling, heart rate was collected every 3 minutes, and session-RPE was recorded 10 minutes after cycling, in 3 communication contexts: in written form unaccompanied (intrapersonal communication), verbally by the researcher only (interpersonal communication), and in the presence of the training group. Session-RPE was analyzed using ordinal regression and heart rate using a linear mixed-effects model, with models fit in a Bayesian framework. Results: Session-RPE was voted higher when collected in the group’s presence compared with when written (odds ratio = 4.26, 95% credible interval = 1.27–14.73). On average, the posterior probability that session-RPE was higher in the group setting than when written was .53. Session-RPE was not different between the group and verbal, or verbal and written collection contexts. Conclusions: This study suggests that contextual psychosocial inputs influence session-RPE and highlights the importance of session-RPE users controlling the measurement environment when collecting votes.
Children’s Changes in Perceptions and Body Composition Following a Family-Based Fitness Intervention
Authors: Carroll Alexandra V. , Foote Shelby J. , Wirth Christopher K. , Brock Sheri J. , Wadsworth Danielle D. 
Published: September 2021

Physical fitness is associated with decreased weight in children, which helps improve youth obesity rates. Family programs can provide practical approaches to improving physical fitness for children. The purpose of this study was to assess the influence of a family-based fitness intervention on changes in body composition, fitness status, and perceptions of obese children. Families attended exercise and education sessions for 60–90 min once per week for 10 weeks. Participants consisted of 10 children who participated in semi-structured interviews, body composition, and fitness assessments at pre- and posttest. Following the intervention, results showed that children had a significant increase in sit-ups (p = .03, effect size = 0.79), lean mass (p < .001, Cohen’sd = 1.95), and bone mineral content (p < .001, Cohen’sd = 0.46). Using thematic analysis, four main themes emerged from the pre- and postintervention interviews: an increase in after-school and weekend intentional physical fitness, rules regarding sedentary behavior and screen time, more prevalent physical fitness reinforcements, and a shift in perception of exercise. Results from this study indicate a family-based intervention had an influence on children’s appreciation for and engagement in physical fitness, as well as healthy body composition and fitness outcomes.
Impact of ActiGraph Sampling Rate and Intermonitor Comparability on Measures of Physical Activity in Adults
Authors: Clevenger Kimberly A. , Brønd Jan Christian , Arvidsson Daniel , Montoye Alexander H.K. , Mackintosh Kelly A. , McNarry Melitta A. , Pfeiffer Karin A. 
Published: September 2021

Background: ActiGraph is a commonly used, research-grade accelerometer brand, but there is little information regarding intermonitor comparability of newer models. In addition, while sampling rate has been shown to influence accelerometer metrics, its influence on measures of free-living physical activity has not been directly studied. Purpose: To examine differences in physical activity metrics due to intermonitor variability and chosen sampling rate. Methods: Adults (n = 20) wore two hip-worn ActiGraph wGT3X-BT monitors for 1 week, with one accelerometer sampling at 30 Hz and the other at 100 Hz, which was downsampled to 30 Hz. Activity intensity was classified using vector magnitude, Euclidean Norm Minus One (ENMO), and mean amplitude deviation (MAD) cut points. Equivalence testing compared outcomes. Results: There was a lack of intermonitor equivalence for ENMO, time in sedentary/light- or moderate-intensity activity according to ENMO cut points, and time in moderate-intensity activity according to MAD cut points. Between sampling rates, differences existed for time in moderate-intensity activity according to vector magnitude, ENMO, and MAD cut points, and time in sedentary/light-intensity activity according to ENMO cut points. While mean differences were small (0.1–1.7 percentage points), this would equate to differences in moderate-to vigorous-intensity activity over a 10-hr wear day of 3.6 (MAD) to 10.8 (ENMO) min/day for intermonitor comparisons or 3.6 (vector magnitude) to 5.4 (ENMO) min/day for sampling rate. Conclusions: Epoch-level intermonitor differences were larger than differences due to sampling rate, but both may impact outcomes such as time spent in each activity intensity. ENMO was the least comparable metric between monitors or sampling rates.
The Use of Collagen with High Concentration in Cartilage Tissue Engineering by Means of 3D-Bioprinting
Authors: Isaeva E. V. , Beketov E. E. , Yuzhakov V. V. , Arguchinskaya N. V. , Kisel A. A. , Malakhov E. P. , Lagoda T. S. , Yakovleva N. D. , Shegai P. V. , Ivanov S. A. , Kaprin A. D. 
Published: September 2021

Abstract3D-bioprinting is a promising technology for a tissue scaffold fabrication in the case of damaged tissue/organ replacement. Collagen is one of the most appropriate hydrogel for the purpose, due to its exceptional biocompatibility. However, the use of collagen with conventionally low concentration makes bioprinting process difficult and does not provide its high accuracy. The purpose of the study was evaluation of suitability of collagen with high concentration in case of chondrocyte-laden scaffold fabrication via 3D-bioprinting for cartilage regeneration in vitro and in vivo. The results of the study showed that inherent porosity of 4% collagen was not enough for cell survival in the case of long-term incubation in vitro. With the beginning of the scaffold incubation, cell migration to the surface and out of the scaffold was observed. The residual cells died mostly within 4 weeks. As for in vivo study, in 2 weeks after implantation of the scaffold, a weak granulomatous inflammation was observed. In 6 weeks, a connective tissue was formed in the area of implantation. In the tissue, macrophages and groups of small cells with round nuclei were found. In accordance with morphological criteria, these cells could be considered as young chondrocytes. However, its amount was not enough to initiate the formation of cartilage.
Ultrasonographic assessment of diaphragmatic contraction and relaxation properties: correlations of diaphragmatic displacement with oesophageal and transdiaphragmatic pressure
Authors: Koco Entela , Soilemezi Eleni , Sotiriou Panagiota , Savvidou Savvoula , Tsagourias Matthew , Pnevmatikos Ioannis , Matamis Dimitrios 
Published: September 2021

Transdiaphragmatic (Pdi) and oesophageal pressures (Pes) are useful in understanding the pathophysiology of the respiratory system. They provide insight into respiratory drive, intrinsic positive end-expiratory pressure, diaphragmatic fatigue and weaning failure.BackgroundThe use of Pdi and Pes in clinical practice is restricted due to the invasiveness of the technique and the cumbersome equipment needed. On the other hand, diaphragmatic displacement is non-invasively and easily assessed with M-mode ultrasound.PurposeWe observed striking similarities in shape and magnitude between M-mode diaphragmatic displacement, Pes and Pdi pressures. The study aimed to evaluate if the information provided by these two pressures could be obtained non-invasively from the diaphragmatic displacement curve.Material and methodsIn 14 consecutive intubated patients undergoing a weaning trial, simultaneous recordings of Pes and Pdi pressures and the diaphragmatic displacement were assessed while breathing spontaneously and during a sniff-like manoeuvre. Moreover, the slope of the diaphragmatic displacement curve during relaxation was compared with the maximal relaxation rate (MRR) obtained from the Pdi curve.ResultsMore than 200 breaths were analysed in pairs. Diaphragmatic displacement significantly correlated with Pdi (R2=0.33, p<0.001) and Pes (R2=0.44, p<0.001), and this correlation further improved during sniff (R2=0.47, p<0.001) and (R2=0.64, p<0.001), respectively. Additionally, a significant correlation was found between the relaxation slope derived from the diaphragmatic displacement curve and the MRR derived from the Pdi curve, both in normal breathing (R2=0.379, p<0.001) and during the sniff manoeuvre (R2=0.71, p<0.001).ConclusionsM-mode diaphragmatic displacement parameters correlate well with the ones obtained from oesophageal pressure and Pdi, particularly during sniffing. Diaphragmatic displacement assessment possibly offers an alternative non-invasive solution for understanding and clinically monitoring the diaphragmatic contractile properties and weaning failure due to diaphragmatic fatigue.
Oncology clinic-based germline genetic testing for exocrine pancreatic cancer enables timely return of results and unveils low uptake of cascade testing
Authors: Wang Yifan , Golesworthy Bryn , Cuggia Adeline , Domecq Celine , Chaudhury Prosanto , Barkun Jeffrey , Metrakos Peter , Asselah Jamil , Bouganim Nathaniel , Gao Zu-Hua , Chong George , Foulkes William D , Zogopoulos George 
Published: September 2021

BackgroundTraditional medical genetics models are unable to meet the growing demand for germline genetic testing (GT) in patients with exocrine pancreatic cancer (PC). This study investigates the impact of an ambulatory oncology clinic-based GT model.MethodsFrom 2012 to 2021, patients with PC were prospectively enrolled and considered for GT. Two chronological cohorts were compared: (1) the preuniversal genetic testing (pre-UGT) cohort, which received GT based on clinical criteria or family history; and (2) the post-UGT cohort, where an 86-gene panel was offered to all patients with PC.ResultsOf 847 eligible patients, 735 (86.8%) were enrolled (pre-UGT, n=579; post-UGT, n=156). A higher proportion of the post-UGT cohort received prospective GT (97.4% vs 58.5%, p<0.001). The rate of pathogenic germline alterations (PGA) across both cohorts was 9.9%, with 8.0% of PGAs in PC susceptibility genes. The post-UGT cohort had a higher prevalence of overall PGAs (17.2% vs 6.6%, p<0.001) and PGAs in PC susceptibility genes (11.9% vs 6.3%, p<0.001). The median turnaround time from enrolment to GT report was shorter in the post-UGT cohort (13 days vs 42 days, p<0.001). Probands with a PGA disclosed their GT results to 84% of their first-degree relatives (FDRs). However, only 31% of informed FDRs underwent GT, and the number of new cases per index case was 0.52.ConclusionA point-of-care GT model is feasible and expedites access to GT for patients with PC. Strategies to increase the uptake of cascade testing are needed to maximise the clinical impact of an oncology clinic-based GT model.
Global and regional burden of interstitial lung disease and pulmonary sarcoidosis from 1990 to 2019: results from the Global Burden of Disease study 2019
Authors: Ma Xiaoqian , Zhu Lili , Kurche Jonathan S , Xiao Huijuan , Dai Huaping , Wang Chen 
Published: September 2021

BackgroundInterstitial lung disease (ILD) and pulmonary sarcoidosis are common respiratory diseases with a heterogeneous distribution worldwide. The global burden and temporal trends of ILD and sarcoidosis are rarely explored.MethodsUsing the classification ‘ILD and pulmonary sarcoidosis’ from the Global Burden of Disease 2019 dataset, we described the age-standardised rates of incidence, mortality, disability-adjusted life-years (DALYs), and their average annual percentage change from 1990 to 2019 by sex, Sociodemographic Index (SDI) and region.ResultsIn 2019, the global incidence and mortality of ILD and pulmonary sarcoidosis were 24.2 million and 169 833 cases, respectively. From 1990 to 2019, the global incidence, deaths and DALYs due to ILD and pulmonary sarcoidosis increased by 118.6%, 166.63% and 122.87% respectively. The global incidence of ILD and pulmonary sarcoidosis was higher in men and was mainly concentrated among persons aged 70‒79 of both sexes. Significant regional differences could be seen in the disease burden of ILD and pulmonary sarcoidosis: since 2006, high-SDI regions had higher age-standardised incidence rates but lower age-standardised death rates compared with the low-SDI regions.ConclusionsOur study suggests the incidence, mortality and DALYs from ILD and pulmonary sarcoidosis are increasing globally. To reduce the ongoing burden of this condition, early diagnosis and treatment are vital, and more targeted and specific strategies should be established in high-burden regions. Differences in incidence and mortality across regions may reflect the influence of genetic, environmental, diagnostic, pharmacotherapeutic, and health system factors.
Unpaired Many-to-Many Disjoint Path Cover of Balanced Hypercubest
Authors: Lü Huazhong , Wu Tingzeng 
Published: September 2021

A many-to-many [Formula: see text]-disjoint path cover ([Formula: see text]-DPC) of a graph [Formula: see text] is a set of [Formula: see text] vertex-disjoint paths joining [Formula: see text] distinct pairs of source and sink in which each vertex of [Formula: see text] is contained exactly once in a path. The balanced hypercube [Formula: see text], a variant of the hypercube, was introduced as a desired interconnection network topology. Let [Formula: see text] and [Formula: see text] be any two sets of vertices in different partite sets of [Formula: see text] ([Formula: see text]). Cheng et al. in [Appl. Math. Comput. 242 (2014) 127–142] proved that there exists paired many-to-many 2-disjoint path cover of [Formula: see text] when [Formula: see text]. In this paper, we prove that there exists unpaired many-to-many [Formula: see text]-disjoint path cover of [Formula: see text] ([Formula: see text]) from [Formula: see text] to [Formula: see text], which has improved some known results. The upper bound [Formula: see text] is best possible in terms of the number of disjoint paths in unpaired many-to-many [Formula: see text]-DPC of [Formula: see text].
Shading Rig: Dynamic Art-directable Stylised Shading for 3D Characters
Authors: Petikam Lohit , Anjyo Ken , Rhee Taehyun 
Published: September 2021

Despite the popularity of three-dimensional (3D) animation techniques, the style of 2D cel animation is seeing increased use in games and interactive applications. However, conventional 3D toon shading frequently requires manual editing to clean up undesired shadows or add stylistic details based on art direction. This editing is impractical for the frame-by-frame editing in cartoon feature film post-production. For interactive stylised media and games, post-production is unavailable due to real-time constraints, so art-direction must be preserved automatically. For these reasons, artists often resort to mesh and texture edits to mitigate undesired shadows typical of toon shaders. Such edits allow real-time rendering but are limited in resolution, animation quality and lack detail control for stylised shadow design.
In our framework, artists build a “shading rig,” a collection of these edits, that allows artists to animate toon shading. Artists pre-animate the shading rig under changing lighting, to dynamically preserve artistic intent in a live application, without manual intervention. We show our method preserves continuous motion and shape interpolation, with fewer keyframes than previous work. Our shading shape interpolation is computationally cheaper than state-of-the-art image interpolation techniques. We achieve these improvements while preserving vector quality rendering, without resorting either to high texture resolution or mesh density.
Combinatorial CRISPR/Cas9 Screening Reveals Epistatic Networks of Interacting Tumor Suppressor Genes and Therapeutic Targets in Human Breast Cancer
Authors: Zhao Xiaoyu , Li Jinyu , Liu Zhimin , Powers Scott 
Published: September 2021

AbstractThe majority of cancers are driven by multiple genetic alterations, but how these changes collaborate during tumorigenesis remains largely unknown. To gain mechanistic insights into tumor-promoting genetic interactions among tumor suppressor genes (TSG), we conducted combinatorial CRISPR screening coupled with single-cell transcriptomic profiling in human mammary epithelial cells. As expected, different driver gene alterations in mammary epithelial cells influenced the repertoire of tumor suppressor alterations capable of inducing tumor formation. More surprisingly, TSG interaction networks were comprised of numerous cliques—sets of three or four genes such that each TSG within the clique showed oncogenic cooperation with all other genes in the clique. Genetic interaction profiling indicated that the predominant cooperating TSGs shared overlapping functions rather than distinct or complementary functions. Single-cell transcriptomic profiling of CRISPR double knockouts revealed that cooperating TSGs that synergized in promoting tumorigenesis and growth factor independence showed transcriptional epistasis, whereas noncooperating TSGs did not. These epistatic transcriptional changes, both buffering and synergistic, affected expression of oncogenic mediators and therapeutic targets, including CDK4, SRPK1, and DNMT1. Importantly, the epistatic expression alterations caused by dual inactivation of TSGs in this system, such as PTEN and TP53, were also observed in patient tumors, establishing the relevance of these findings to human breast cancer. An estimated 50% of differentially expressed genes in breast cancer are controlled by epistatic interactions. Overall, our study indicates that transcriptional epistasis is a central aspect of multigenic breast cancer progression and outlines methodologies to uncover driver gene epistatic networks in other human cancers.Significance:This study provides a roadmap for moving beyond discovery and development of therapeutic strategies based on single driver gene analysis to discovery based on interactions between multiple driver genes.See related commentary by Fong et al., p. 6078
Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma
Authors: Singh Kirit , Batich Kristen A. , Wen Patrick Y. , Tan Aaron C. , Bagley Stephen J. , Lim Michael , Platten Michael , Colman Howard , Ashley David M. , Chang Susan M. , Rahman Rifaquat , Galanis Evanthia , Mansouri Alireza , Puduvalli Vinay K. , Reardon David A. , Sahebjam Solmaz , Sampson John H. , Simes John , Berry Donald A. , Zadeh Gelareh , Cloughesy Tim F. , Mehta Minesh P. , Piantadosi Steven , Weller Michael , Heimberger Amy B. , Khasraw Mustafa 
Published: September 2021

Abstract
Immunotherapy has revolutionized treatment for many hard-to-treat cancers but has yet to produce significant improvement in outcomes for patients with glioblastoma. This reflects the multiple and unique mechanisms of immune evasion and escape in this highly heterogeneous tumor. Glioblastoma engenders profound local and systemic immunosuppression and is remarkably effective at inducing T-cell dysfunction, posing a challenge to any immunotherapy-based approach. To overcome these mechanisms, multiple disparate modes of immune-oriented therapy will be required. However, designing trials that can evaluate these combinatorial approaches requires careful consideration. In this review, we explore the immunotherapy resistance mechanisms that have been encountered to date and how combinatorial approaches may address these. We also describe the unique aspects of trial design in both preclinical and clinical settings and consider endpoints and markers of response best suited for an intervention involving multiple agents.