bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of oxidative status and inflammation in patients with arterial hypertension and subclinical hypothyroidism and their relationship to aging rates
Authors: Radchenko A. O. , Kolesnikova O. V. 
Published: June 2021

Objective — to assess the oxidative status and severity of inflammatory processes in patients with hypertension (AH) and subclinical hypothyroidism (SH) and their relationship to the rate of aging.
Materials and methods. 98 patients (38 men and 61 women) of young and middle age with a median age of 48.3 years were examined. All patients were divided into 3 groups: controls — healthy volunteers (n = 20), comparison group — euthyroid patients with AH and signs of autoimmune thyroiditis (AIT) (n = 36); main group — patients with AH and SH with signs of AIT (n = 42). Thyroid parameters, markers of oxidative stress (total superoxide dismutase, T‑SOD, total antioxidant activity, TAA, total hydroperoxides, THP), inflammatory markers (C‑reactive protein, SRP, tumor necrosis factor‑alpha, TNF‑a) were evaluated in all patients. The rate of aging was determined by estimating the biological age and age delta according to the methods of A. G. Gorelkin, B. B. Pinhasov (BA1, dBA1 respectively) and V. P. Voitenko (BA2, dBA2, respectively), as well as by determining the content of sirtuin 1 (SIRT1).
Results. Significant differences were found between the controls and the comparison group in the rate of aging by both methods (p < 0.05), between the control and the main group in the levels of CRP (p = 0.000), TNF‑a (p = 0.000), aging rates by both methods (p < 0.05), as well as between the comparison and the main groups in the values of CRP (p = 0.001), TNF‑a (p = 0.000), THP (p = 0.041), T‑SOD (p = 0.048), SIRT1 (p = 0.001), dBA2 (p = 0.030). Correlation analysis revealed a significant (p < 0.05) direct relationship between the rate of aging and the level of CRP, free thyroxine, THP, THP/TAA index, and the inverse relationship between the rate of aging and T‑SOD, TAA in the comparison group. A significant direct relationship (p < 0.05) between CRP and BA1, a direct relationship between TNF‑a and thyroid‑stimulating hormone (TSH) levels and a direct association of T‑SOD with TSH and inverse one with BA1 were found in the main group.
Conclusions. Patients with AH have a decrease in the rate of aging and a significant increase in SIRT1 compared with euthyroid patients with AH, that indicates a probable association with a slowing of aging rates. A significant increase in THP and a decrease in and T‑SOD levels, along with the presence of a connection with TSH and BA1, indicates a violation of redox processes in this category of patients and its association with aging rates. Patients with AH and SH also showed signs of metabolic inflammation, which was confirmed by a significant increase in the levels of TNF‑a, CRP, as well as by the presence of a direct link between TNF‑a and TSH. BA and aging rates increased with increasing CRP levels in euthyroid patients with AH, but no association between CRP and TSH was observed.
Preoperative Determination of Tibia Length Using Contralateral Tibial Tubercle-Medial Malleolar Distance (TMD) in Western Part of Nepal
Authors: Shrestha Kishor Man , Kandel Prakriti Raj , Shrestha Bipan , Shrestha Shreshal 
Published: June 2021

INTRODUCTION
Intramedullary (IM) nailing is most commonly preferred for adult tibial shaft fracture. The objective of this study was to find the accuracy of predicting the tibial nail length pre-operatively from contra-lateral tibial tubeorsity to medial malleolar distance (TMD) length.
MATERIAL AND METHODS
After ethical clearance (UCMS/IRC/239/19) from the Institutional Review Board (IRB) of Universal College of Medical Sciences, all patients with recent fracture of tibia, who fulfilled the inclusion criteria were enrolled in the study and the informed written consent was obtained. The study was conducted on 45 patients of aged more than 15 years who attended Universal College of Medical Sciences Teaching Hospital (UCMS-TH) over a period of one year (Nov 2019 to Oct 2020). The TMD length of contra-lateral leg were measured preoperatively using a measuring tape and the ideal length of IM nail were measured intra-operatively using IM tibial nail under fluoroscopic guidance.
RESULTS
Analysis showed that majority of patients were males (77.78%) out of total 45 patients. The mean length of TMD length of contra-lateral leg and the ideal length of IM nail were 33.067 ±1.60 and 33.11 ±1.68 respectively. The mean difference between these two measurements was 0.04 (95% CI, -0.64 to 0.72). The significant correlation was found between these two measurements i.e r=0.88 by Pearson’s correlation (95% CI, 0.79 to 0.93), (p<0.001). Most of the TMD length were equal (37.78%) to ideal length of IM nail.
CONCLUSION
We recommended TMD length measurement of contralateral leg as an excellent anthropometric parameter for preoperative planning.
Surgical Management of Tibial Plateau Fractures with Locking Compression Plate
Authors: Shrestha Bipan , Kandel Prakriti Raj , Shrestha Kishor Man , Shrestha Shreshal , Yadav Rakesh 
Published: June 2021

INTRODUCTION
Tibial plateau fracture is a common fracture that accounts for 1-2% of all fracture. Various treatment options including proximal tibial plating with locking compression plates are available for the treatment of tibial plateau fracture. This study was done to determine the clinical profile and functional outcome of tibial plateau fracture following locking compression plating.

MATERIAL AND METHODS
This prospective and observational study was carried out in Orthopedics Department of Universal College of Medical Sciences-Teaching Hospital (UCMS-TH) from December 2018 to July 2020. After Ethical clearance (UCMS/IRC/224/18) from Institutional Review Board (IRB) of UCMS-TH and informed written consent, all patients with tibial plateau fracture (Schatzker II-VI) who fulfilled the inclusion criteria were enrolled in the study and treated with locking compression plate. Post-operatively patients were regularly followed at 6 weeks, 3 months and 6 months for clinical, radiological and functional assessment. Descriptive statistics like frequency, percentage, mean and standard deviation were used to analyze the data.

RESULTS
In our study of 30 cases, the mean age was 37.77 ±15.65 years. Most of the cases were Schatzker type VI (13 patients) and type II (9 patients). The average duration for fractures union was 23.4 ±2.1 weeks. Superficial wound infection was the common complication seen in five cases. At six months, the mean knee society score (KSS) was 78 ±7.22 and majority of patients (19 patients) had good results.

CONCLUSION
Locking compression plate has an excellent functional and radiological outcome. It is an effective implant that can be adopted for the treatment of tibial plateau fractures in adults.
Prevalence and Pattern of Rheumatic Heart Disease among Reproductive Age Group Female
Authors: Shrestha Manoj , Aryal Prakash 
Published: June 2021

INTRODUCTION
Rheumatic heart disease (RHD) remains a major public health problem in developing countries. In low income countries RHD accounts for approximately 90% of all cardiovascular disease among pregnant women. This study aims to evaluate the prevalence and pattern of RHD among reproductive age group women presenting to a tertiary care teaching hospital in Central Nepal.
MATERIAL AND METHODS
Prospective observational study was carried out in College of Medical Sciences Teaching Hospital, Bharatpur, Nepal from January 2019 to December 2019 by doing transthoracic echocardiography (TTE) of reproductive age group females (n=800) from 15 years to 45 years of age. The data were collected in pre-structured proforma.
RESULTS
Out of 800 patients, RHD was present in 46 (5.75%) patients. The incidence of RHD was found to be highest in the age group of 30-35 years 13 (28.3%) and the mean age of presentation was 29.24 years. Mitral valve was the most common valve involvement and mitral regurgitation 37 (80.4%) was the most common valvular dysfunction present in patients with RHD.
CONCLUSION
The prevalence of RHD among reproductive age group female is high and mitral valve is the most commonly affected valve.
Serum Vitamin D and B12 Levels in Alcoholic Male Patients: A Cross-sectional Study
Authors: Jayan Archana , Pokhrel Buddhi Raj , Gautam Narayan , Jha Amit Chandra , Tamang Binaya , Shrestha Jharana , Ranjan Sanjeev , Dubey Raju Kumar 
Published: June 2021

INTRODUCTION
Alcohol dependence is a global problem and is rapidly increasing in developing countries. We aimed to analyze the serum levels of vitamin B12 and vitamin D in chronic alcoholic patients and their association with parameters of liver function.
MATERIAL AND METHODS
A cross-sectional study was carried out in Universal College of Medical Sciences, Bhairahawa, Nepal from March 2020 to September 2020 on patients visiting the Psychiatric Out Patient Department (OPD) for the treatment of alcohol dependence. The patients were categorized as excessive and moderate drinkers. Serum vitamin B12, vitamin D, and hepatic function parameters were measured.
RESULTS
The median serum vitamin B12 and vitamin D levels were 467.8 pg/ml and 24.9 ng/ml respectively. Excessive drinkers had significantly higher B12 levels than moderate drinkers. Vitamin B12 levels correlated positively with liver function parameters, as well as alcohol amount and duration of consumption. Vitamin D levels were insufficient in 57 (71.25%) of the overall participants.
CONCLUSION
Serum levels of vitamin B12 are not affected in patients with alcohol dependence. Alcohol consumption, however, reduces serum concentrations of vitamin D. Vitamin B12 concentration is positively associated with liver enzymes and other parameters of liver function.
Mayavini Sarsi (Circe): Devkota’s Reworking to Western Myths
Authors: Chalise Keshav Raj 
Published: June 2021

Laxmi Prasad Devkota, celebrated poet as the Mahakavi or Poet the Great wasborn in 1966 BS. Writing in distinct style from the tradition, Devkota has broken the convention in Nepalese writing, both in form and content, though he was in the difficult mode of free expression due to Rana observation over writings and even the discouraging situation on free thinking and creative writing.
He has adapted Sanskrit tradition of writing epics, (Mahakavya) and also, he has composed the epic on free verse. He has introduced and applied western Romantic trend of writing poetry. With these new modes, he has introduced new genre and approach in writing poems and other forms of literature. Openness, lucidity and honesty are some of the characteristics of Devkota’s poetic works. His feelings, sensibility and expressions have been blended perfectly and brilliantly with words and meanings that have created an explosion of thoughts and ideas in his writings. We find spontaneous expression in his poems and there is no artificial sense.
As a versatile writer, he has composed in all literary genres, pomes, epics, essays, plays and fictions, but he is basically a poet. Having with the knowledge both in eastern Sanskrit literature and western literary traditions, he has combined both traditions in his Nepali writings. With the use of the western and eastern mythical references, he has united the traditions of the both in his writings. This article aims to observe his revisit to the eastern and western mythical references in Mayavini Circe, the epic on free verse.
CONCEPTUAL MODEL OF INNOVATIVE ECONOMIC DEVELOPMENT
Authors: Kovalenko Elena 
Published: June 2021

The article emphasizes that Ukrainian government must choose the way of widespread innovation and building a competitive state. Increasing the competitiveness of Ukraine is possible only providing the establishing of innovative development mechanisms and technological improvement of the national economy.
The main obstacles of Ukraine's transition to an innovative model of development have been identified. Innovation processes in the economy have not gained significant scale, the number of enterprises implementing innovations is decreasing every year and today is 12-14 %, which is 3-4 times less than in innovative economies countries. It is concluded that the intensive development of innovation in modern conditions provides a basis for sustainable economic growth, which provides an opportunity to argue about the innovative type of economic development in contrast to the stagnant, evolutionary, extensive. The course for innovative development in Ukraine determines the transition of the economy to a new qualitative state.
It is proved that in the current crisis situation in Ukraine, there is a problem to develop a model of sustainable economic growth, the solution of which will be the basis for a qualitatively new type of economic development. The qualitative characteristic of innovative economy and principles of its full-fledged effective functioning are resulted. The current system and level of financing of innovation activity in Ukraine, which requires both qualitative and quantitative changes, introduction of state and non-state financial methods aimed at intensification of innovation activity are analyzed. The necessity of transition to the innovative economy has been substantiated, which will give an opportunity not only to bring Ukraine's economy out of crisis, but also to accelerate economic growth, which will ensure further stable socio-economic development of society. A conceptual model of innovative economic development is proposed.
The role of State innovation policy in Ukraine is defined, which would ensure the creation of socio-economic, organizational and legal conditions for the effective reproduction, development and use of the scientific and technical potential of the country.
DEVELOPMENT OF THE MODEL OF ENTERPRISE GROWTH ON THE BASIS OF TECHNOLOGY TRANSFER ACTIVATION IN THE FORM OF JOINT ENTREPRENEURSHIP
Authors: Chernyavs'ka Iryna 
Published: June 2021

Technology transfer is an important element in ensuring the growth of technological development and competitiveness of the modern enterprise. Joint venture as one of the specific forms of technology transfer gives participating companies the opportunity to attract significant investment, new management technologies, stimulates the production process of competitive products and facilitates technological exchange. Today, the problem of participation in various forms of joint ventures, which is an appropriate method of achieving competitive advantage through cooperation, is becoming relevant for the development of domestic enterprises. Solving problematic issues requires detailing the limitations of joint ventures and researching the areas of common interests of its subjects.
The aim of the study is to develop an effective model of intensifying technology transfer in the form of joint ventures based on the interaction of partner entities. The spheres of independent interests of the subjects of joint venture are researched and determined, the factors of guaranteed result are determined. The basis for the analysis was the scientific studies of domestic and foreign scientists on this issue. The theoretical and methodological basis of the study is a set of principles and methods of scientific research: the principle of systematization and theoretical generalization, methods of structural and functional analysis.
The results of the study showed that the conflict of interests of the subjects of joint venture arises in situations where there is a tendency to integration and the subjects expect to get a certain guaranteed result. It has been proved that a necessary condition for ensuring mutually beneficial cooperation of individual joint ventures is the existence of a guarantee of useful results, and partnership within the joint venture is based on common interests and goals to be achieved in the results of activities and aimed at consolidating cooperation of individual participants through joint ventures. The implementation of the developed model of enterprise development based on the intensification of technology transfer, which describes the continuous changes in the process of functioning of the form of joint venture over time, can have a useful effect on its successful operation. The practical value of the model is that individual entities, regardless of their own economic policies and the nature of their interests, have a common area of compromise in which they can conduct joint ventures.
THE FEATURES OF ACCOUNT RECEIVABLES ACCOUNTING AT COKE ENTERPRISES
Authors: Kemarska Liliia 
Published: June 2021

The article examines the features of account receivables accounting at coke enterprises in Ukraine. Different approaches for defining the «account receivable» term by domestic and foreign researchers were examined, the difference between interpretations was determined. Various approaches to the account receivable classification were explored, the classification attributes were generalized on the basis of the conducted research. It was proposed to extend the existing classification with the following attributes: by agreement with counterparties, by currency of debt, by legitimacy of occurrence. According to the added classification attributes, the types of account receivables were distinguished (сoncerted and the unconcerted account receivable on a sum and terms, for example, not confirmed claims fines; real and fictitious account receivable, that is represented in an account without actual realization of economic operation or as a result of economic operations that is confessed by a court as incompetent). The features of account receivables accounting at the PJSC “DNIPROVSKY CCP” were examined. In accordance with the chosen accounting policy, the classification of account receivables at the enterprise was highlighted. The features of registration of primary documents of origin and repayment of account receivable for various business transactions were analyzed. The features of recognition and assessment of account receivable, the procedure for forming the provision for doubtful debts were revealed, the procedure and grounds for writing off debts, the features of its reflection in the financial statements were determined. For more detailed accounting of account receivables in the enterprise, measures to improve accounting were proposed. For account receivables accounts in the enterprise, it is proposed to introduce sub-accounts for accounting of debts for which the payment deadline has not come, and debts that have not been repaid on time. For accounting the doubtful debt reserve for long-term and short-term account receivables it’s proposed to introduce separate sub-accounts to the account of the accounting of the doubtful debts reserve. Based on the proposals made the changes to the working card of accounts of the PJSC “DNIPROVSKY CCP” were developed.
Perfilometría 3D por proyección desenfocada de patrones binarios
Authors: Silva A. , Flores J. L. , Muñoz A. , García-Torales G. 
Published: June 2021

Las técnicas basadas en proyección de luz estructurada son ampliamente estudiadas y utilizadas en el área de perfilometría tridimensional, esto debido a la capacidad para obtener información completa de la superficie de objetos. Algunas de estas técnicas se basan en la proyección de patrones de intensidad sinusoidal y el uso de algoritmos de corrimiento de fase. En el caso de la reconstrucción tridimensional de objetos dinámicos en movimiento, uno de los desafíos es reducir el número de pasos o imágenes a ser proyectadas. Sin embargo, la precisión de estos sistemas se reduce conforme decrece el número de patrones (a un mínimo de tres). El sistema de proyección presenta una respuesta no lineal, lo cual introduce armónicos en los patrones adquiridos y en la recuperación de fase. En los últimos años, la proyección desenfocada de patrones binarios para generar patrones de franjas cuasi sinusoidales ha emergido como una alternativa para evitar el problema de no linealidad del proyector y, por ende, reducir el error en la fase. En este trabajo se presenta una revisión de distintos métodos propuestos en la literatura para generar patrones binarios, los cuales sintetizan patrones cuasi sinusoidales cuando son proyectados fuera de foco. Adicionalmente, analizamos el error de fase en función a la cantidad de desenfoque y el tamaño del periodo fundamental de las franjas. The techniques of structured light projection are widely studied in the area of three-dimensional profilometry, due to its ability to obtain information from the surface of an object. In particular, those based on the projection of a sequence of sinusoidal intensity patterns and the use of phase shift algorithms. In the case of three-dimensional reconstruction of dynamic or moving objects, one of the trends is to reduce the number of steps or patterns to be projected. However, the accuracy of these systems is reduced as the number of steps decreases (to a minimum of 3 steps). This is because the projection systems present a non-linear response, which translates into the introduction of harmonics in the acquired sinusoidal patterns, and therefore, error in the recovered phase. In the last years, the defocused projection of binary patterns has emerged as an alternative to avoid the projector’s non-linearity and generates quasi-sinusoidal fringe patterns to reduce the phase error. In this work, we review different techniques that have been proposed in the literature to generate binary patterns, which synthesize quasi-sinusoidal patterns when projected out of focus. In addition, we analyze the error in the phase as a function of the defocusing amount and the fringe pitch.
METAPHORS OF LOVE IN THE BELARUSIAN DISCOURSE OF THE 21ST CENTURY
Authors: Vasilevskaya Elena 
Published: June 2021

The purpose of the work is to identify the functional and stylistic role and semantics of metaphors of love used in the modern Belarusian language. The source of the material was the texts of the belles-lettres and journalistic style written in the 21st century, in which the issues of the relationships between a man and a woman are raised. The article is based on the short novel “Between Day and Night” by N. Rybik, materials from collections of stories by Belarusian writers, periodicals and the Belarusian N‑corpus were also used.
The descriptive method was chosen as the main one; the article uses elements of functional and stylistic and contextual analysis.
Analysis of the metaphorical use of words used by modern Belarusian authors to describe various stages of the appearance of feelings and the degree of their manifestation shows that the attitude towards love in the modern Belarusian society is changing significantly. Love is often perceived not as something mysterious and extraordinary, but as something that you need to create yourself, using all available means for this (play, imitate, apply witchcraft, etc.). The main thing in love is to subjugate a person, bind them to oneself, which is realized in the use of the words ‘to hook’, ‘to woo’, etc. Marriage is perceived as something fickle (to try marriage) and divorce is perceived as a temporary measure (to part).
Love is also considered as a disease that subjugates the will of a person, destroys them, which is emphasized by the use of metaphors like madness, to go nuts, etc.
Lovehunting appears, which requires a large selection of partners (casting, asset), special skills and long practice (maneuvering).
The external traits of a person become most important in relationships, therefore, the metaphors supermodel and swan princess are often used to describe young and beautiful women.
Significant changes in the feeling are reflected in the choice of synonyms for the word ‘love’: surrogate, syrup, etc.
Thus, the analysis of the figurative use of words allows us to outline the main changes that are taking place in the sphere of human relations in the Belarusian society of the 21st century.