bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental investigation on water release and gas emission of evapotranspirative capillary barrier landfill covers
Authors: Chen Rui , Huang Junwen , Leung Anthony Kwan , Chen Zhongkui , Chen Zibin 
Published: October 2021

AbstractEvapotranspirative (ET) landfill covers release soil moisture stored therein by grass root–water uptake during the drying process. The reduction of soil water content during this process, however, would cause an increase in gas permeability and landfill gas emission. Few studies have focused on the mechanisms of water release and gas emission in ET covers under drying conditions and how different cover configurations might affect the water–gas transport mechanisms. In this study, a series of soil column tests were conducted to investigate the water and gas transport in three configurations of ET covers, namely monolithic cover, two‐layer capillary barrier cover (CBC), and three‐layer CBC. All columns were subjected to the same drying treatment for 42 h followed by the application of a constant gas pressure at the column base. Vertical distributions of pore water pressure, volumetric water content, and pore gas pressure, as well as any gas emission rate from the top of each cover were measured. Compared with the monolithic ET cover, the two‐layer capillary barrier ET cover did not adversely affect the cumulative amount of water release, but the presence of the coarse‐grained layer, which has relatively high gas permeability, caused a higher gas emission rate. In the three‐layer cover, the addition of a low‐permeability layer underneath the capillary barrier effectively minimized gas emission. On the other hand, the upper two‐layer capillary barrier can avoid desiccation cracks of the low‐permeability layer during the drying period.
“If You’re Gonna be Inclusive, You have to be Inclusive on all Levels”: Ableism in Teacher Collaboration
Authors: Phuong Jennifer , DiPasquale Katherine , Rivera Natalie 
Published: October 2021

AbstractIn this piece, we explore how ableism manifests in teacher collaboration, focusing on the experiences of English as a Second Language teachers and special education teachers. We broaden the definition of ableism to consider how schools rely on ideas of some students as normal and others as not, leading to a service delivery model. The service delivery model results in fragmented and compartmentalized views of students that see language and disability needs as distinct, thus leading to difficulties for the teachers who work with students who are labeled disabled and as English Learners. We end with reflection questions for administrators and educators to consider to better serve the needs of their students.
Symmetry resolved relative entropies and distances in conformal field theory
Authors: Capizzi Luca , Calabrese Pasquale 
Published: October 2021

Abstract
We develop a systematic approach to compute the subsystem trace distances and relative entropies for subsystem reduced density matrices associated to excited states in different symmetry sectors of a 1+1 dimensional conformal field theory having an internal U(1) symmetry. We provide analytic expressions for the charged moments corresponding to the resolution of both relative entropies and distances for general integer n. For the relative entropies, these formulas are manageable and the analytic continuation to n = 1 can be worked out in most of the cases. Conversely, for the distances the corresponding charged moments become soon untreatable as n increases. A remarkable result is that relative entropies and distances are the same for all symmetry sectors, i.e. they satisfy entanglement equipartition, like the entropies. Moreover, we exploit the OPE expansion of composite twist fields, to provide very general results when the subsystem is a single interval much smaller than the total system. We focus on the massless compact boson and our results are tested against exact numerical calculations in the XX spin chain.
Knowledge and skills of emergency physicians in managing traumatic dental injuries
Authors: Wolfer S. , von Hahn N. , Sievers D. , Hohenstein Ch. , Kauffmann P. 
Published: October 2021

Abstract
Purpose
Emergency departments are frequently confronted with traumatic dental injuries (TDIs). The prognosis of the injured tooth is related to early dental trauma management. For this reason, physicians must be familiar with the appropriate management of TDI. This study aimed to investigate the knowledge and skills of German emergency physicians regarding TDI.

Methods
An electronic questionnaire was sent to 438 emergency departments throughout Germany. Four hundred and twenty seven questionnaires were evaluated and included in the analysis. The survey contained questions about physician characteristics and assessed their knowledge and skills of managing dental trauma. For statistical analysis, the Kruskal–Wallis, Mann–Whitney U test or ANOVA test was used as appropriate. Rank correlations were performed with the Spearman’s rank correlation.

Results
Out of 427 participants, 256 (59.95%) stated they had no or insufficient knowledge, and 266 (71.12%) stated they had no skills in dental trauma management. Almost 76% of the participants had no previous knowledge of dentistry. Only 7.28% knew the right procedure for replanting an avulsed tooth. Just 26.06% would choose the right medium for temporary tooth storage. Having a dentist in the family (p = 0.0074) or clinical exposure to patients with dental trauma (p = 0.0384) influenced the results of the knowledge score.

Conclusion
The knowledge and skills in dental trauma management among German emergency physicians are generally inadequate. Targeted training courses are necessary to ensure early and adequate TDI treatment to reduce the resulting medical and societal costs as much as possible.
Steady-state ferumoxytol-enhanced MRI: early observations in benign abdominal organ masses and clinical implications
Authors: Shahrouki Puja , Felker Ely R. , Raman Steven S. , Jeong Woo Kyoung , Lu David S. , Finn J. Paul 
Published: October 2021

Abstract
Introduction
The off-label use of ferumoxytol as a vascular MR imaging agent is growing rapidly. However, the properties of ferumoxytol suggest that it may play an important role in the detection and characterization of abdominal mass lesions.

Methods
Thirty-six patients with benign abdominal mass lesions who underwent MR angiography with ferumoxytol also had T2-weighted HASTE imaging and fat-suppressed 3D T1-weighted imaging. The T1 and T2 enhancement characteristics of the lesions were analyzed and correlated with other imaging modalities and/or surgical findings and/or clinical follow-up.

Results
In all patients with benign masses in the liver (n = 22 patients), spleen (n = 6 patients), kidneys (n = 33 patients), adrenal (n = 2 patients) and pancreas (n = 4 patients), based on the enhancement characteristics with ferumoxytol, readers were confident of the benign nature of the lesions and their conclusions were consistent with correlative imaging, tissue sampling and follow-up. One patient with a suspicious enhancing 2F Bosniak renal cyst had renal cell carcinoma confirmed on biopsy.

Conclusion
Ferumoxytol-enhanced MRI can increase diagnostic confidence for benign abdominal masses and can increase the conspicuity of mass lesions, relative to unenhanced MRI.

Graphic Abstract
PD-1 expression in hepatocellular carcinoma predicts liver-directed therapy response and bridge-to-transplant survival
Authors: Núñez Kelley G. , Sandow Tyler , Fort Daniel , Hibino Mina , Wright Paige , Cohen Ari J. , Thevenot Paul T. 
Published: October 2021

Abstract
Background
Hepatocellular carcinoma (HCC) patients undergo liver-directed therapy (LDT) to control tumor burden while awaiting liver transplantation with response impacting waitlist survival. In this study, we investigate the link between absolute lymphocyte count (ALC) and PD-1 expression with response to LDT and bridge-to-transplant survival.

Methods
Treatment-naïve HCC patients (n = 86) undergoing LDT were enrolled at a single center from August 2016–March 2020. Response to LDT was determined using mRECIST. Blood samples were collected on the day of LDT and at follow-up. Cells were analyzed for phenotype by flow cytometry. Outcomes were liver transplantation or tumor progression.

Results
Incomplete response to initial LDT was associated with tumor progression precluding liver transplantation (OR: 7.6, 1.7 – 33.3, P < 0.001). Univariate analysis of baseline T cell phenotypes revealed ALC (OR: 0.44, 0.24–0.85, P = 0.009) as well as intermediate expression of PD-1 on CD4 (OR: 3.3, 1.03–10.3, P = 0.034) and CD8 T cells (OR: 3.0, 0.99–8.8 P = 0.043) associated with incomplete response to LDT. Elevations in PD-1 expression were associated with increased risk of bridge-to-transplant tumor progression (HR: 3.2, 1.2–9.4). In patients successfully bridged to liver transplantation, pre-treatment peripheral PD-1 profile was associated with advanced tumor staging (P < 0.005) with 2/4 of patients with elevations in PD-1 having T3-T4 TNM staging compared to 0 with low PD-1 expression.

Conclusion
Low lymphocyte count or elevated expression of the PD-1 checkpoint inhibitor is associated with incomplete response to LDT and increased risk of bridge-to-transplant tumor progression. Patients with impaired T cell homeostasis may benefit from PD-1 immunotherapy to improve response to LDT and improve bridge-to-transplant outcomes.
Comprehensive analysis of NGS and ARMS-PCR for detecting EGFR mutations based on 4467 cases of NSCLC patients
Authors: He Changlong , Wei Chengcheng , Wen Jun , Chen Shi , Chen Ling , Wu Yue , Shen Yifan , Bai Huili , Zhang Yangli , Chen Xueping , Li Xiaosong 
Published: October 2021

Abstract
Background
By comparing the detection rate and type of targeted gene mutations in non-small cell lung cancer (NSCLC) between amplification refractory mutation system PCR (ARMS-PCR) and next-generation sequencing (NGS), the characteristics and application advantages of non-small cell lung cancer detection are explained, providing a basis for clinicians to effectively select the corresponding detection methods.

Methods and materials
The cases of targeted genes for lung cancer were selected from the First Affiliated Hospital of Chongqing Medical University from January 2016 to October 2020. A sample of 4467 cases was selected, and they were diagnosed with NSCLC by Pathological biopsy. Sample sources include surgical resection, bronchoscope biopsy, metastatic biopsy, blood, sputum, cytology of pleural effusion. Among them, 3665 cases were detected by ARMS-PCR technique, and 802 cases were detected by NGS technology. The detection rate and type of ARMS-PCR and NGS techniques for EGFR gene mutations (including exon 18, exon 19, exon 20, exon 21 and so on) in different NSCLC samples were compared, respectively.

Results
The total mutation rate of EGFR gene detected by ARMS-PCR was 47.6% while 42.4% detected by NGS which indicated that there was a significant difference between the two methods in detecting total mutation of EGFR gene (P < 0.001). In different exons, the EGFR mutation rate detected by two methods is various. The mutation rate of exon 19 by ARMS-PCR detection was evidently higher than that of NGS detection, while the mutation rate of exons 20 and 21 by ARMS-PCR detection were statistically significantly lower than that of NGS detection. Moreover, the multiple mutation rate detected by NGS was 16.3% which was much higher than the 2.7% detected by ARMS-PCR with statistically different.

Conclusion
It showed that NGS could direct the drug use for the resistant patients. However, some rare loci could be detected by NGS but the importance and directed meaning are still unknown and the number of rare mutations is rare too. Further research on new biomarkers and technique is still needed for early diagnosis, directing drug use and assessing the therapy prognosis.
Urinary excretion of amino acids and their advanced glycation end-products (AGEs) in adult kidney transplant recipients with emphasis on lysine: furosine excretion is associated with cardiovascular and all-cause mortality
Authors: Baskal Svetlana , Post Adrian , Kremer Daan , Bollenbach Alexander , Bakker Stephan J. L. , Tsikas Dimitrios 
Published: October 2021

AbstractArginine (Arg) and lysine (Lys) moieties of proteins undergo various post-translational modifications (PTM) including enzymatic NG- and Nε-methylation and non-enzymatic NG- and Nε-glycation. In a large cohort of stable kidney transplant recipients (KTR, n = 686), high plasma and low urinary concentrations of asymmetric dimethylarginine (ADMA), an abundant PTM metabolite of Arg, were associated with cardiovascular and all-cause mortality. Thus, the prediction of the same biomarker regarding mortality may depend on the biological sample. In another large cohort of stable KTR (n = 555), higher plasma concentrations of Nε-carboxymethyl-lysine (CML) and Nε-carboxyethyl-lysine (CEL), two advanced glycation end-products (AGEs) of Lys, were associated with higher cardiovascular mortality. Yet, the associations of urinary AGEs with mortality are unknown. In the present study, we measured 24 h urinary excretion of Lys, CML, and furosine in 630 KTR and 41 healthy kidney donors before and after donation. Our result indicate that lower urinary CML and lower furosine excretion rates are associated with higher mortality in KTR, thus resembling the associations of ADMA. Lower furosine excretion rates were also associated with higher cardiovascular mortality. The 24 h urinary excretion rate of amino acids and their metabolites decreased post-donation (varying as little as − 24% for CEL, and as much as − 62% for ADMA). For most amino acids, the excretion rate was lower in KTR than in donors pre-donation [except for S-(1-carboxyethyl)-l-cysteine (CEC) and NG-carboxyethylarginine (CEA)]. Simultaneous GC–MS measurement of free amino acids, their PTM metabolites and AGEs in urine is a non-invasive approach in kidney transplantation.
Mathematical models and heuristic algorithms for pallet building problems with practical constraints
Authors: Calzavara Gabriele , Iori Manuel , Locatelli Marco , Moreira Mayron C. O. , Silveira Tiago 
Published: October 2021

AbstractIn the pallet building problem, we aim at loading a given set of items into one or more pallets, by satisfying specific constraints and minimizing the number of pallets used. In this paper, we address a practical case of this problem that originates from a real-world robotized application, subject to some non-trivial operational constraints. In practice, items are grouped into families and must be packed into horizontal layers. To facilitate loading/unloading operations, items of the same type packed into the same layer should be contiguous and at least one of them should be visible from the outside. We present a formal mathematical description for layer and pallet creation subproblems and then we propose heuristic, metaheuristic, matheuristic algorithms to solve the overall problem. The performance of the algorithms is assessed through extensive computational tests on real-world instances.
Environmental management systems in the architectural, engineering and construction sectors: a roadmap to aid the delivery of the sustainable development goals
Authors: Horry Rosemary , Booth Colin A. , Mahamadu Abdul–Majeed , Manu Patrick , Georgakis Panos 
Published: October 2021

AbstractRealisation of the sustainable development goals (SDGs) will provide improvements to people's lives and longevity of the planet. The architectural, engineering and construction (AEC) sectors have a potentially huge role in aiding the delivery of many SDGs; however, there appears to be a lack of research into the engagement within this sector. The leading environmental management system (EMS), ISO 14001, can enable organisations in the AEC sectors to improve their business operations, whilst minimising their impacts on the environment and improving society. Therefore, the study sets out to use institutional theory to determine the usefulness of ISO 14001 as a tool within the AEC sector and to demonstrate how the organisational benefits could facilitate the delivery of the SDGs. A stepwise PRISMA review process facilitated the compiling of academic articles and professional reports (n = 44), which enabled the creation of an inventory of the perceived benefits (n = 85) and the recognised barriers (n = 63) to implementing ISO 14001 across the AEC sectors. These barriers and benefits were confirmed by environmental practitioners as being relevant to the incorporation of an EMS. The most widely reported benefits within the AEC sectors were improving environmental performance and compliance with legislation. Lack of government pressure and lack of expertise were the most widely reported barriers, followed by cost to AEC organisations utilising an EMS. Following on from this inventory of benefits, it was possible to develop of a conceptual roadmap, which illustrates where linkages exist with the SDGs. SDG 4, 8, 12 and 13 are shown as exhibiting the most associations with the benefits. This roadmap was reviewed by AEC sector professionals who confirmed its usefulness. Therefore, it is surmised that the roadmap could aid strategic organisational sustainable planning or for organisations to demonstrate the delivery of their corporate social responsibilities.
Recent-onset atrial fibrillation: a study exploring the elements of Virchow’s triad after cardioversion
Authors: Arvanitis Panagiotis , Johansson Anna-Karin , Frick Mats , Malmborg Helena , Gerovasileiou Spyridon , Larsson Elna-Marie , Blomström-Lundqvist Carina 
Published: October 2021

Abstract
Purpose
Atrial fibrillation (AF) imposes an inherent risk for stroke and silent cerebral emboli, partly related to left atrial (LA) remodeling and activation of inflammatory and coagulation systems. The aim was to explore the effects of cardioversion (CV) and short-lasting AF on left atrial hemodynamics, inflammatory, coagulative and cardiac biomarkers, and the association between LA functional recovery and the presence of a prior history of AF.

Methods
Patients referred for CV within 48 h after AF onset were prospectively included. Echocardiography and blood sampling were performed immediately prior, 1–3 h after, and at 7–10 days after CV. The presence of chronic white matter hyperintensities (WMH) on magnetic resonance imaging was related to biomarker levels.

Results
Forty-three patients (84% males), aged 55±9.6 years, with median CHA2DS2-VASc score 1 (IQR 0–1) were included. The LA emptying fraction (LAEF), LA peak longitudinal strain during reservoir, conduit, and contractile phases improved significantly after CV. Only LAEF normalized within 10 days. Interleukin-6, high-sensitivity cardiac-troponin-T (hs-cTNT), N-terminal-pro-brain-natriuretic peptide, prothrombin-fragment 1+2 (PTf1+2), and fibrinogen decreased significantly after CV. There was a trend towards higher C-reactive protein, hs-cTNT, and PTf1+2 levels in patients with WMH (n=21) compared to those without (n=22). At 7–10 days, the LAEF was significantly lower in patients with a prior history of AF versus those without.

Conclusion
Although LA stunning resolved within 10 days, LAEF remained significantly lower in patients with a prior history of AF versus those without. Inflammatory and coagulative biomarkers were higher before CV, but subsided after 7–10 days, which altogether might suggest an enhanced thrombogenicity, even in these low-risk patients.
Transformation of a rolling mill aggregate to a cyber physical production system: from sensor retrofitting to machine learning
Authors: Ralph Benjamin James , Sorger Marcel , Hartl Karin , Schwarz-Gsaxner Andreas , Messner Florian , Stockinger Martin 
Published: October 2021

AbstractThis paper describes the transformation of a rolling mill aggregate from a stand-alone solution to a fully integrated cyber physical production system. Within this process, already existing load cells were substituted and additional inductive and magnetic displacement sensors were applied. After calibration, those were fully integrated into a six-layer digitalization architecture at the Smart Forming Lab at the Chair of Metal Forming (Montanuniversitaet Leoben). Within this framework, two front end human machine interfaces were designed, where the first one serves as a condition monitoring system during the rolling process. The second user interface visualizes the result of a resilient machine learning algorithm, which was designed using Python and is not just able to predict and adapt the resulting rolling schedule of a defined metal sheet, but also to learn from additional rolling mill schedules carried out. This algorithm was created on the basis of a black box approach, using data from more than 1900 milling steps with varying roll gap height, sheet width and friction conditions. As a result, the developed program is able to interpolate and extrapolate between these parameters as well as different initial sheet thicknesses, serving as a digital twin for data-based recommendations on schedule changes between different rolling process steps. Furthermore, via the second user interface, it is possible to visualize the influence of this parameters on the result of the milling process. As the whole layer system runs on an internal server at the university, students and other interested parties are able to access the visualization and can therefore use the environment to deepen their knowledge within the characteristics and influence of the sheet metal rolling process as well as data science and especially fundamentals of machine learning. This algorithm also serves as a basis for further integration of materials science based data for the prediction of the influence of different materials on the rolling result. To do so, the rolled specimens were also analyzed regarding the influence of the plastic strain path on their mechanical properties, including anisotropy and materials’ strength.
A series acceleration algorithm for the gamma-Pareto (type I) convolution and related functions of interest for pharmacokinetics
Authors: Wesolowski Carl A. , Alcorn Jane , Tucker Geoffrey T. 
Published: October 2021

AbstractThe gamma-Pareto type I convolution (GPC type I) distribution, which has a power function tail, was recently shown to describe the disposition kinetics of metformin in dogs precisely and better than sums of exponentials. However, this had very long run times and lost precision for its functional values at long times following intravenous injection. An accelerated algorithm and its computer code is now presented comprising two separate routines for short and long times and which, when applied to the dog data, completes in approximately 3 min per case. The new algorithm is a more practical research tool. Potential pharmacokinetic applications are discussed.Graphic abstract