bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Venous Endothelial Cells in Developmental and Pathologic Angiogenesis
Authors: Lee Heon-Woo , Xu Yanying , He Liqun , Choi Woosoung , Gonzalez David , Jin Suk-Won , Simons Michael 
Published: September 2021

Background:
Angiogenesis is a dynamic process that involves expansion of a preexisting vascular network that can occur in a number of physiological and pathological settings. Despite its importance, the origin of the new angiogenic vasculature is poorly defined. In particular, the primary subtype of endothelial cells (capillary, venous, arterial) driving this process remains undefined.

Methods:

Endothelial cells were fate-mapped with the use of genetic markers specific to arterial and capillary cells. In addition, we identified a novel venous endothelial marker gene (
Gm5127
) and used it to generate inducible venous endothelium-specific Cre and Dre driver mouse lines. Contributions of these various types of endothelial cells to angiogenesis were examined during normal postnatal development and in disease-specific setting.

Results:
Using a comprehensive set of endothelial subtype-specific inducible reporter mice, including tip, arterial, and venous endothelial reporter lines, we showed that venous endothelial cells are the primary endothelial subtype responsible for the expansion of an angiogenic vascular network. During physiological angiogenesis, venous endothelial cells proliferate, migrating against the blood flow and differentiating into tip, capillary, and arterial endothelial cells of the new vasculature. Using intravital 2-photon imaging, we observed venous endothelial cells migrating against the blood flow to form new blood vessels. Venous endothelial cell migration also plays a key role in pathological angiogenesis. This was observed both in formation of arteriovenous malformations in mice with inducible endothelium-specific Smad4 deletion mice and in pathological vessel growth seen in oxygen-induced retinopathy.

Conclusions:
Our studies establish that venous endothelial cells are the primary endothelial subtype responsible for normal expansion of vascular networks, formation of arteriovenous malformations, and pathological angiogenesis. These observations highlight the central role of the venous endothelium in normal development and disease pathogenesis.
Two Myths of Representational Measurement
Authors: Tal Eran 
Published: September 2021

Abstract
Axiomatic measurement theories are commonly interpreted as claiming that, in order to quantify an empirical domain, the qualitative structure of data about that domain must be mapped to a numerical structure. Such mapping is supposed to be established independently, i.e., without presupposing that the domain can be quantified. This interpretation is based on two myths: that it is possible to independently infer the qualitative structure of objects from empirical data, and that the adequacy of numerical representations can only be justified by mapping such qualitative structures to numerical ones. I dispel the myths and show that axiomatic measurement theories provide an inadequate characterization of the kind of evidence required to detect quantities.
“Like Son, Like Father”
Authors: MacLachlan David 
Published: September 2021

Abstract
Markus Barth’s book Die Taufe: Ein Sakrament? had an evident and important influence on the development of his father Karl Barth’s theological understanding of the nature and practice of Christian baptism. This essay explores that influence, considers its scope and significance, and suggests in the course of so doing that the relationship between the elder and the younger Barth is a notable factor in what led to the provocative theology of baptism at which Karl Barth arrived in the late, fragmentary volume of the Church Dogmatics.
The Canary Intermediate Poleward Undercurrent: Not Another Poleward Undercurrent in an Eastern Boundary Upwelling System
Authors: Vélez-Belchí P. , Caínzos V. , Romero E. , Casanova-Masjoan M. , Arumí-Planas C. , Santana-Toscano D. , González-Santana A. , Pérez-Hernández M. D. , Hernández-Guerra A. 
Published: September 2021

AbstractPoleward undercurrents are well-known features in eastern boundary upwelling systems. In the California Current upwelling system, the California poleward undercurrent has been widely studied, and it has been demonstrated that it transports nutrients from the equatorial waters to the northern limit of the subtropical gyre. However, in the Canary Current upwelling system, the Canary intermediate poleward undercurrent (CiPU) has not been properly characterized, despite recent studies arguing that the dynamics of the eastern Atlantic Ocean play an important role in the Atlantic meridional overturning circulation, specifically on its seasonal cycle. Here, we use trajectories of Argo floats and model simulations to characterize the CiPU, including its seasonal variability and its driving mechanism. The Argo observations show that the CiPU flows from 26°N, near Cape Bojador, to approximately 45°N, near Cape Finisterre and flows deeper than any poleward undercurrent in other eastern boundaries, with a core at a mean depth of around 1000 dbar. Model simulations manifest that the CiPU is driven by the meridional alongshore pressure gradient due to general ocean circulation and, contrary to what is observed in the other eastern boundaries, is still present at 1000 dbar as a result of the pressure gradient between the Antarctic Intermediate Waters in the south and Mediterranean Outflow waters in the north. The high seasonal variability of the CiPU, with its maximum strength in autumn and minimum in spring, is due to the poleward extension of AAIW, forced by Ekman pumping in the tropics.
Suicide Rates and Differences in Rates Between Non-Hispanic Black and Non-Hispanic White Populations in the 30 Largest US Cities, 2008-2017
Authors: Schober Daniel J. , Benjamins Maureen R. , Saiyed Nazia S. , Silva Abigail , Shrestha Susana 
Published: September 2021

Objectives Suicide is a leading cause of death in the United States, and rates vary by race and ethnicity. An analysis of suicide across large US cities is absent from the literature. The objective of this study was to examine suicide rates among the total population, non-Hispanic Black population, and non-Hispanic White population in the United States and in the 30 largest US cities. Methods We used data from the National Vital Statistics System to calculate non-Hispanic White, non-Hispanic Black, and total age-adjusted suicide rates for the 30 largest US cities and for the entire nation during 2 periods: 2008-2012 and 2013-2017. We also examined absolute and relative differences in suicide rates among non-Hispanic White populations and non-Hispanic Black populations in each city. Results The overall age-adjusted suicide rate per 100 000 population in the United States increased significantly from 12.3 in 2008-2012 to 13.5 in 2013-2017. Total suicide rates were stable in most cities; rates increased significantly in only 1 city (Louisville), and rates decreased significantly in 2 cities (Boston and Memphis). The non-Hispanic White suicide rate was significantly higher—1.3 to 4.3 times higher—than the non-Hispanic Black suicide rate in 24 of 26 study cities during 2013-2017. From 2008-2012 to 2013-2017, non-Hispanic White suicide rates decreased significantly in 3 cities and increased significantly in 3 cities; non-Hispanic Black suicide rates increased significantly in 5 cities and decreased in none. Absolute differences in suicide rates among non-Hispanic White populations and non-Hispanic Black populations increased significantly in 1 city (Louisville) and decreased significantly in 2 cities (Memphis and Boston). Conclusions Our study may inform the use of evidence-based programs and practices to address population-level risk factors for suicide.
A method to predict electric vehicles’ market penetration as well as its impact on energy saving and CO2 mitigation
Authors: Fu Shijun , Fu Hongji 
Published: September 2021

Introduction: Although forecasting electric vehicles’ growth in China was frequently reported in the literature, predicting electric vehicles market penetration as well as corresponding energy saving and carbon dioxide mitigation potential in a more suitable method is not well understood. Methods: This study chose the double species model to predict electric vehicles’ growth trajectory under mutually competitive conditions between electric vehicles and internal combustion engine vehicles. For comparison, it set two scenarios: with 200 and 300 vehicles per thousand persons at 2050. To give details on energy saving and carbon dioxide mitigation potential induced by electric vehicles’ market penetration, it further divided electric vehicles into five subgroups and internal combustion engine vehicles into seven subgroups, therein forming respective measurement formulas. Results: This paper solved the double species model and thus got its analytical formula. Then it employed the analytical formula to conduct an empirical study on electric vehicles market penetration in China from year 2010 to 2050. Under scenario 300, electric vehicles growth trajectory will emerge a quick growth stage during 2021–2035, thereafter keeping near invariant till 2050. Meanwhile, current internal combustion engine vehicles’ quick growth will continue up to 2027, then holding constant during 2028–2040, afterwards following a 10-year slowdown period. Scenario 200 has similar features, but a 2-year delay for electric vehicles and a 5-year lead time for internal combustion engine vehicles were found. On average, scenario 300 will save 114.4 Mt oil and 111.5 Mt carbon dioxide emissions, and scenario 200 will save 77.1 Mt oil and 73.4 Mt carbon dioxide emissions each year. Beyond 2032, annual 50.0% of road transport consumed oil and 18.6% of carbon dioxide emissions from this sector will be saved under scenario 300. Discussion: Compared with scenario 200, scenario 300 was more suitable to predict electric vehicle market penetration in China. In the short-term electric vehicle penetration only brings about trivial effects, while in the long-term it will contribute a lot to both energy security and carbon dioxide mitigation. The contribution of this article provided a more suitable methodology for predicting electric vehicle market penetration, simulated two coupled trajectories of electric vehicles and internal combustion engine vehicles, and discussed relative energy-saving and climate effects from 2010 to 2050.
Lumbar motor control training as a complementary treatment for chronic neck pain: A randomized controlled trial
Authors: Khosrokiani Zohre , Letafatkar Amir , Gladin Amy 
Published: September 2021

Objective: We investigated whether adding lumbar motor control training with a pressure biofeedback unit improves outcomes of a conservative deep cervical flexor motor control program on neck pain, neck disability, deep cervical flexor endurance, and health status in middle-aged patients with chronic neck pain and forward head posture after eight weeks of interventions. Design: Randomized controlled trial. Setting: Outpatient setting. Subjects and interventions: A total of 113 males and females (mean age 39 ± 5 years) with chronic neck pain were randomized to three treatment groups, group 1 ( n = 38) combined deep cervical flexor motor-control training and lumbar motor control exercise, group 2 ( n = 37) deep cervical flexor motor control training alone, and group 3 ( n = 38) passive treatment and education. Main outcome measures: Pain, neck disability, deep cervical flexor muscular endurance, and health status. Results: There were significant improvements in the combination group compared with the deep cervical flexor motor-control group alone ( d = 2.03, 95% confidence interval (CI): −2.8 to −1.27, P = 0.021) for pain ( d = −0.99, 95% CI = −1.75 to −0.23, P = 0.023), disability ( d = 1.92, 95% CI = 0.86 to 2.98, P = 0.001), deep cervical flexor endurance, and ( d = −2.75, 95% CI = −8.81 to −1.68, P = 0.037) for health status favoring the combination group. There were significant between-group differences favoring both active groups versus the passive control in all out comes. Conclusion: The addition of Lumbar motor control training as a complementary treatment may enhance effectiveness of deep cervical flexor motor control training on neck pain, neck disability, and deep cervical flexor endurance in patients with chronic moderate neck pain and forward head posture.
Navigating the caregiving abyss: A metasynthesis of how family caregivers manage end-of-life care for older adults at home
Authors: Michaels Jacqueline , Chen Chiahui , Ann Meeker Mary 
Published: September 2021

Background: Demographic changes (global aging, decreased fertility, increased home deaths) will present a critical need for end-of-life family caregivers of older adults at home. In order to support these family caregivers, we need to better understand their experiences, struggles, and needs. Aim: To describe and explain the process of end-of-life caregiving as experienced by family caregivers of older adults residing in the home setting. Design: The Preferred Reporting Items for Systematic Reviews and Metaanalysis (PRISMA) guidelines and Sandelowski and Barroso’s procedural steps for a metasynthesis review guided this study. Data sources: Qualitative and mixed methods literature from CINAHL, Medline, PsycINFO, and EMBASE databases and information from professional organizations were reviewed for studies that focused on family caregivers providing end-of-life care to older adults residing in the home setting. Results: A total of 24 studies were identified. Family caregivers engaged in the process of “navigating a caregiving abyss” when providing and managing end-of-life-care for older adults at home. The “caregiving abyss” consisted of four phases: (1) managing multiple roles, (2) encountering challenges, (3) mobilizing resources, and (4) acknowledging death is near. During the process family caregivers strived to “live day by day” and “maintain normalcy” to achieve the goals of honoring life’s final wishes and provide home death. Conclusion: Family caregivers of older adults at the end of life navigate a variety of challenges. The findings provide a conceptual framework to help guide the development of education, interventions, and health policy to meet family caregivers’ needs in providing quality end-of-life care.
Platelet-Rich Plasma Augmentation of Meniscal Repair in the Setting of Anterior Cruciate Ligament Reconstruction
Authors: Bailey Lane , Weldon Matthew , Kleihege Jacquelyn , Lauck Kyle , Syed Mohammad , Mascarenhas Randy , Lowe Walter R. 
Published: September 2021

Background: The increasing incidence of anterior cruciate ligament (ACL) and meniscal injuries has led to strong interest in discovering new methods to enhance the biological healing response of these tissues. Platelet-rich plasma (PRP) contains various growth factors associated with a positive healing response, but few existing clinical studies are available to determine the risks and benefits of these therapies. Purpose: To determine the effects of intraoperative PRP on postoperative knee function and complications at 2 years after ACL reconstruction with meniscal repair. Study Design: Cohort study; Level of evidence, 3. Methods: A retrospective matched case-control study was conducted between 2013 and 2017 using a single surgeon database of 1014 patients undergoing primary ACL reconstruction with concomitant meniscal repair, resulting in 324 patients (162 PRP patients and 162 control patients) who met the study criteria. Patients were matched by age, sex, graft type, and meniscal injury. The Single Assessment Numeric Evaluation (SANE) was administered at 2 years, and injury surveillance was conducted. Secondary outcomes included the time to return to activity (months), self-reported knee function (International Knee Documentation Committee [IKDC] score), functional performance testing (knee range of motion, single-leg balance, single-leg hopping, agility testing), and postoperative complications (graft failure, infection, loss of motion [requiring repeat arthroscopy for lysis of adhesions], venous thrombosis, etc). Univariate models were used for between-group comparisons, and alpha was set at .05 for all analyses. Results: No differences were found in SANE knee function scores between the PRP and matched-control groups at 2 years (91.6 ± 11.2 vs 92.4 ± 10.6, respectively; P = .599). Additionally, no differences were reported between groups for self-reported function (IKDC score, 87.6 ± 13.3 vs 88.1 ± 12.6; P = .952), functional performance testing ( P > .05), and timing of return to activity (7.8 ± 1.9 vs 8.0 ± 1.9 months; P = .765). The PRP group demonstrated a higher rate of postoperative knee motion loss compared with the control group (13.6% vs 4.6%; P < .001). No other differences were observed in postoperative complications ( P > .05). Conclusion: The added use of intraoperative PRP did not improve self-reported knee function, functional performance, and timing of return to activity for patients undergoing ACL reconstruction with meniscal repair. Furthermore, the use of PRP may have negative consequences for regaining knee range of motion after surgery. On the basis of these data, surgeons should cautiously consider the application of PRP when planning surgery for intra-articular injuries of the knee. Registration: NCT03704376 ( ClinicalTrials.gov identifier).
Exosome-derived miR-2682-5p suppresses cell viability and migration by HDAC1-silence-mediated upregulation of ADH1A in non-small cell lung cancer
Authors: Mao Guangxian , Mu Zhimin , Wu Da 
Published: September 2021

Introduction: Increasing evidence indicated that miR-2682-5p acted as a tumor suppressor in various cancers. The current study aimed to investigate the biological function of exosomal miR-2682-5p in non-small cell lung cancer (NSCLC). Methods: The expression of miR-2682-5p in NSCLC tissues and adjacent non-tumor tissues, NSCLC cell lines and human embryonic lung fibroblast, as well as serum and serum exosomes of NSCLC patients and healthy donors was detected by RT-qPCR. The effects of miR-2682-5p on the viability, migration, and apoptosis of NSCLC cells were detected by CCK-8, Transwell, and flow cytometry assays. Dual-luciferase reporter gene and RNA immunoprecipitation assays were used to evalutate the relationship between miR-2682-5p and HDAC1. Results: Low expressed miR-2682-5p was found in tumor tissues, cell lines, serum, and serum exosomes of NSCLC patients. MiR-2682-5p overexpression suppressed NSCLC cell viability and migration and promoted apoptosis, while miR-2682-5p knockdown showed the opposite results. Furthermore, exosomes from healthy donor serum inhibited NSCLC cell viability and migration and promoted apoptosis. Dual-luciferase reporter gene and RNA immunoprecipitation assays verified that HDAC1 was a target of miR-2682-5p. HDAC1 overexpression abolished the effects of miR-2682-5p mimic on NSCLC cell viability, migration, and apoptosis. Chromatin immunoprecipitation assay indicated that HDAC1 bound to the promoter region of ADH1A. Upregulation of ADH1A counteracted the effects of HDAC1 overexpression on NSCLC cell viability, migration, and apoptosis. Conclusion: Taken together, exosomal miR-2682-5p inhibited NSCLC cell viability and migration and promoted apoptosis by the HDAC1/ADH1A axis, and this result might provide a novel therapeutic target for NSCLC.
Patients’ Awareness of Advanced Disease Status, Psychological Distress and Quality of Life Among Patients With Advanced Cancer: Results From the APPROACH Study, India
Authors: Satija Aanchal , Bhatnagar Sushma , Ozdemir Semra , Finkelstein Eric , Maholtra Chetna , Teo Irene , Yang Grace Meijuan 
Published: September 2021

Background: Prognostic disclosure to patients with advanced cancer facilitates treatment decisions and goals of care discussions. However, the perspectives of patients, families and physicians differ in this regard across different cultures. Non-disclosure of cancer diagnosis or prognosis is commonly observed in family-centric cultures such as India. Aim: To assess the prevalence of and factors associated with cancer patients’ awareness of advanced disease status; and its with quality of life and psychological distress. Methods: Patients for this cross-sectional questionnaire-based survey were recruited from oncology and palliative medicine clinics at a tertiary cancer hospital in India from January 2017 to June 2018. Patients aged ≥ 21 years, aware of cancer diagnosis and receiving oncology treatment for Stage IV solid cancer were included in the study after obtaining written informed consent. Results: Two hundred patients were enrolled, of which 146 (73%) were not aware of the stage of their malignancy and 9 (4.5%) believed that their disease was at stage I, II or III. Those who were aware of their advanced cancer stage had more years of education (9.9 years vs 8.1 years, p = .05) and had poorer spiritual wellbeing in the faith domain (adjusted difference −1.6, 95% confidence interval −3.1 to −0.1, p = .03) compared to those who were unaware. Conclusion: It is recommended that future studies may explore prognostic understanding in Indian patients according to their socio-cultural, spiritual and educational background.
Productive Efficiency and Non-performing Assets of Indian Banks in the Post-global Financial Crisis Period
Authors: Khati Karan Singh , Mukherjee Deep 
Published: September 2021

This study endeavours to augment the existing literature on the productive efficiency of Indian domestic banks in the presence of non-performing assets (NPAs), by employing the Weighted Russell Directional Distance Model (WRDDM). Following the intermediation approach, the banking technology set includes three inputs, three desirable outputs and one undesirable output, namely NPAs. Due to their inherent technological heterogeneity, public sector banks (PSBs) and private banks (PVBs) have been analysed as separate groups. Balanced panels of 26 PSBs and 18 PVBs are constructed from 2010-2011 to 2016-2017. The results indicate a considerable scope of improvement in the productive performance of both categories of banks. The break-up of overall inefficiency into input- and output-specific components reveals some stimulating information. For PSBs, the inefficiencies primarily result due to physical capital, while for PVBs they emerge mainly from other incomes. However, NPAs are also a key contributor to inefficiency for both the categories of banks. The inefficiency scores also indicate that, across ownership categories, medium-sized banks are poorer performers than their smaller and larger counterparts. JEL: C14, C61, D24, G21