bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteoporotic Hip Fractures in the Elderly: Is there a Gender Difference?
Authors: Wan Sharifah Aishah , Tiong Ing Khieng , Chuah Seow Lin , Cheong Yaw Kiet , Singh Benjamin Sachdev Manjit , Lee Kar Hoo , Lee Wendy Wan Hui , Teh Cheng Lay , Tiong Jeh Kiong , Samsudin Affizal , Jobli Ahmad Tirmizi 
Published: October 2021

Abstract
BackgroundOsteoporosis and osteoporotic fracture pose a major public health problem in our aging population. Osteoporotic hip fractures carry an increased morbidity and mortality, with some difference seen between men and women. While overall diagnosis and treatment for osteoporosis have improved, osteoporosis in men remain underdiagnosed and undertreated.AimWe aim to describe the difference in clinical characteristics between elderly men and women with osteoporotic hip fractures in Sarawak General Hospital.MethodsAll patients diagnosed with osteoporotic hip fracture admitted to Sarawak General Hospital from June 2019-March 2021 were recruited and demographic data and clinical features were obtained.ResultsThere were 140 patients with osteoporotic hip fracture, and 40 were men (28.6%). The mean age for males were 74.1 ± 9.5 years, while the mean age for females were 77.4 ± 9.1 years (p=0.06). The types of fracture consisted of neck of femur=78, intertrochanteric=61, and subtrochanteric=1. There were 20 men with secondary osteoporosis (50%), while 13 women (13%) had secondary osteoporosis (p<0.001). The causes of secondary osteoporosis among the men were hypogonadism, COPD, GIOP, renal disease, ADT, thyroid disorder, prostate cancer, and previous gastrectomy. There were two deaths among the men and four deaths among the women during the inpatient and 3 months follow up period. There was no statistical significance between the mortality rates between male patients (5%) and female patients (4%) (p=0.55). ConclusionThere were more females with osteoporotic hip fractures, and there were significantly more males with secondary osteoporotic hip fractures.Trial registration: This study (Male osteoporotic hip fracture in Sarawak General Hospital) was registered with the Malaysian National Medical Research Register (NMRR). Trial registration number: NMRR-19-323-46068 IIR
Isolated Metastasis of the Ascending Ramus of the Mandible of Thyroid Follicular Carcinoma: A Case Report and Literature Review
Authors: Zhang Siyao , Sun Qingjia , Zhu Dongdong 
Published: October 2021

Abstract
Objectives: The mandibular metastatic spread of carcinoma from the thyroid gland is exceedingly rare. In August 2020, we treated a 69-year-old woman exhibiting thyroid follicular carcinoma metastasis to the ascending ramus region of the mandible showing evidence of detailed radiological and pathological features. Methods: We present a case report of thyroid carcinoma that metastasized to the ascending ramus region of the mandible at 21 years after partial thyroidectomy. We also present relevant information in a literature review of 35 articles, consisting of 43 cases (including our case) of thyroid carcinomas with jaw bone metastasis. We statistically analyzed the demographical and clinical results in terms of age, sex, type of primary cancer, site and time of metastasis, treatment, and outcome.Results: Unlike most of the other cases, in our case, the thyroid cancer had metastasized to the ascending ramus region of the mandible, which made the diagnosis relatively difficult. The patient underwent partial mandibular resection, thyroidectomy, and iodine-131 treatment. The patient was followed up regularly, and no new symptoms were observed at seven months after post-treatment.Conclusions: Surgery is the most common treatment for thyroid metastases of the mandible. Clinicians should ask thyroid cancer patients for follow-up to monitor whether any new complications have occurred. Patients must undergo complete examination of the maxillofacial bone for up to 40 years or more. Otolaryngologists and stomatologists should pay extra attention to patients with thyroid cancer or nodules to avoid misdiagnosis or missing the recognition of thyroid metastatic cancer.
Radiomics for Precision Medicine in Glioblastoma
Authors: Aftab Kiran , Aamir Faiqa Binte , Mallick Saad , Mubarak Fatima , Pope Whitney B. , Mikkelsen Tom , Rock Jack P. , Enam Ather 
Published: October 2021

Abstract
Introduction: Being the most common primary brain tumor, glioblastoma presents as an extremely challenging malignancy to treat with dismal outcomes despite treatment. Varying molecular epidemiology of glioblastoma between patients and intra-tumoral heterogeneity explains the failure of current one-size-fits-all treatment modalities. Radiomics uses machine-learning to identify salient features of the tumor on brain imaging and promises patient specific management in glioblastoma patients. Methods: We performed a comprehensive review of the available literature on studies investigating the role of radiomics and radiogenomics models for the diagnosis, stratification, prognostication as well as treatment planning and monitoring of glioblastoma.Results: Classifiers based on combination of various MRI sequences, genetic information and clinical data can predict non-invasive tumor diagnosis, overall survival and treatment response with reasonable accuracy. However, the use of radiomics for glioblastoma treatment remains in infancy as larger sample sizes, standardized image acquisition and data extraction techniques are needed to develop machine learning models that can be translated effectively into clinical practice. Conclusion: Radiomics has the potential to transform the scope of glioblastoma management through personalized medicine.
Modifications in Gamma-aminobutyric Acid type A Receptor Subunit Gene Expression During Macrophage Differentiation and Propofol Administration in THP-1 Cells
Authors: Kochiyama Tsukasa , Kawagoe Izumi , Yamaguchi Ai , Fukuda Masataka , Hayashida Masakazu 
Published: October 2021

Abstract
Background: Gamma-aminobutyric acid type A (GABAA) receptors are thought to play a role in the functioning of the immune system. GABAA receptors have 19 types of subunits, the components of which determine their physiological functions. However, the subunits that are expressed in immune cells during inflammation have not been fully investigated. Recent reports have shown that anesthetic agents may affect the gene expression of GABAA receptors subunits in immune cells. Therefore, we aimed to investigate the changes in GABAA receptor subunit gene expression during macrophage differentiation and propofol administration in order to clarify the relationship between the expression of GABAA receptors and the immunomodulatory effect of propofol.Methods: Human acute monocytic leukemia (THP-1) cells were differentiated into macrophage-like cells (M0 THP-1); subsequently, M0 THP-1 cells were differentiated into inflammatory M1 macrophage-like cells (M1 THP-1). Propofol was administered during the differentiation into M1 THP-1 cells. Using reverse transcriptase polymerase chain reaction, we examined which GABAA receptor subunit genes were expressed and whether there were changes in the gene expression during macrophage differentiation and propofol administration in THP-1 cells.Results: The expression of the α1, α4, β1, β2, γ1, and γ2 subunits increased during differentiation into M0 THP-1 cells. The expression of the α1, α4, β1, β2, γ2, and δ subunits decreased and that of the γ1 subunit increased during differentiation into M1 THP-1 cells. The gene expression of the α1, α4, and β2 subunits increased upon administering propofol during differentiation into M1 THP-1 cells.Conclusions: The gene expression of GABAA receptor subunits changed during macrophage differentiation in THP-1 cells. The expressions of α1 and α4 increased following propofol administration during the differentiation into M1 THP-1 cells, which may indicate that the GABAA receptor is involved in the immunosuppressive effects of propofol. This study can help in the choice of anesthetic agents for proinflammatory conditions such as highly-invasive surgery.
Double-high insert presents with worse mid-term outcomes in cruciate-retaining medial-pivotal total knee arthroplasty – a propensity score matched analysis with averaged 8-year follow-up
Authors: Xiang Shuai , Wang Yingzhen , Lv Chengyu , Wang Changyao , Zhang Haining 
Published: October 2021

Abstract
Background

The aim of this study was to compare the mid-term clinical and radiographic outcomes between medial-pivotal (MP) insert and double-high (DH) insert used under cruciate-retaining condition in ADVANCE® total knee arthroplasty (TKA).
Methods

The follow-up was conducted for 158 consecutive patients underwent unilateral ADVANCE® TKA from January 2011 to April 2014. 84 MP inserts and 74 DH inserts were used under cruciate-retaining condition. A 1:1 propensity score matching (PSM) analysis was performed between MP insert and DH insert to compare the clinical and radiographic outcomes.
Results

After a 1:1 PSM, 120 patients (60 pairs) were matched between MP insert and DH insert. The baseline demographic parameters and clinical scores were comparable between the two groups. The postoperative clinical outcomes at an averaged 8-year follow-up of both groups were significantly improved. The range of motion (ROM) of DH group was better than that of MP group and equivalent Knee Society Function Score (KSFS) between the two groups was found. However, the Knee Society Score (KSS), Western Ontario and McMaster Universities Arthritis Index (WOMAC) score and Forgotten Joint Score (FJS) of MP group were found to be significantly superior than those of DH group. Comparable complication rate and revision rate were observed between the two groups. The radiographic results were also equally good between MP and DH group.
Conclusions

Although the mid-term clinical and radiographic outcomes of DH insert are fairly good, the clinical scores of DH group were worse than those of MP group.
A Microbial Tale of Farming, Invasion and Conservation: On the Gut Bacteria of European and American Mink in Western Europe
Authors: Leeuwen Pauline ML Van , Schulte-Hostedde Albrecht I , Fournier-Chambrillon Christine , Fournier Pascal , Pigneur Lise-Marie , Aranda Carmen M , Urra-Maya Fermìn , Michaux Johan 
Published: October 2021

Abstract
One of the threats that the critically endangered European mink (Mustela lutreola) faces throughout its relict range, including the occidental population, is the impact of the American mink (Mustela vison) invasion in its natural habitat. We aimed to explore the differences in microbiota and genetic diversity between European and American mink to test phylosymbiosis theory. We investigated the gut microbiota composition of European and American mink in a controlled environment (captive breeding compounds and fur farms respectively) to account for the impact of the environment on gut bacterial composition. We compared them to the gut microbiota of both mink species in the natural environment across multiple habitats. Our exploratory results showed differences between free-ranging and captive individuals, with more extreme changes in American mink compared to European mink. However, feral American mink from a long-established population exhibited gut bacterial composition closer to the free-ranging native species compared to more recently established feral populations. This result could be explained by dietary shifts in the area sampled based on prey availability through different landscape, but also to a lesser extent due to greater genetic differentiation. This exploratory work contributes to the scarce literature currently available on the dynamics between gut microbiota and mammal invasion.
Marginal defects modified graphene with S-C-N-C groups for highly selective oxygen reduction to H2O2
Authors: Mou Zhixing , Mu Yue-Wen , Liu Lijia , Cao Daili , Chen Shuai , Yan Wenjun , Zhou Haiqing , Chan Ting-Shan , Chang Lo-Yueh , Qian Yumin , Fan Xiujun 
Published: October 2021

Abstract
Developing efficient metal-free catalysts to achieve electrochemical synthesis of hydrogen peroxide (H2O2) is crucial for substituting traditional energy-intensive anthraquinone process. Heteroatom-doped carbon materials have shown great potential toward 2e-pathway for catalyzing oxygen reduction to hydrogen peroxide (ORHP). However, conventional nanocarbon electrocatalysts show slow kinetics toward ORHP due to the weak binding strength with OOH* intermediate, resulting reduction of O2 to H2O. Here, sulfur and nitrogen dual-doped graphene (SNC) electrocatalyst consisting of S-C-N-C functional group are synthesized through hydrothermal self-assembly and nitridation processes with thiourea as sulfur source. In S-C-N-C functional group, pentagon-S and pyrrolic-N are covalently grafted onto the edge of graphene and produce marginal carbon ring defects, which provide highly active sites for catalyzing ORHP. The obtained SNC catalysts deliver an outstanding ORHP activity and selectivity for H2O2 production, while retaining remarkable stability. The experimental and computational results reveal that marginal S-C-N-C functional groups afford an appropriate adsorption strength with OOH* intermediate and a low reaction barrier as well, which are essential for the activity of ORHP.
Preventing Adverse Events of Chemotherapy for Gastrointestinal Cancer by Educating Patients about the Nocebo Effect: A Randomized-controlled Trial
Authors: Michnevich Twyla L. , Pan Yiqi , Hendi Armin , Oechsle Karin , Stein Alexander , Nestoriuc Yvonne 
Published: October 2021

Abstract
Background: Adverse events of chemotherapy may be caused by pharmacodynamics or psychological factors such as negative expectations, which constitute nocebo effects. In a randomized controlled trial, we examined whether educating patients about the nocebo effect is efficacious in reducing the intensity of self-reported adverse events. Methods: N = 49 and n = 51 patients (mean age: 60.2 years, 65% male, 54% UICC tumour stage IV) with newly-diagnosed gastrointestinal cancer were allocated to a nocebo education and attention control group, respectively.Results: GLM with adjustments for tumour staging and distress indicated that intensity of adverse events differed at 12-weeks after onset of chemotherapy (mean difference: 4.04, 95% CI [0.72, 7.36], p = .02, d = 0.48), with lower levels in the nocebo education group. Of these,). This was attributable to less non-specific adverse events (mean difference: 0.39, 95% CI [0.04, 0.73], p = .03, d = 0.44) and a trend towards less specific adverse events in the nocebo education group (mean difference: 0.36, 95% CI [-0.02, 0.74], p = .07, d = 0.37). We found no difference in adverse events at 10-days follow-up, perceived control of adverse events, or tendency to misattribute non-specific symptoms to the chemotherapy. Conclusions: This study provides first proof-of-concept evidence for the efficacy of a brief information session in preventing adverse events of chemotherapy. However, results regarding patient-reported outcomes cannot rule out response biases. Informing patients about the nocebo effect may be an innovative and clinically feasible intervention for reducing the burden of adverse events.Trial registration: retrospectively registered on March 27, 2018 to the German Clinical Trial Register (ID: DRKS00009501).
Risk of Developing Second Malignant Neoplasms in Patients with Neuroblastoma: A Population Study of the US SEER Database
Authors: Zhen Hongnan , Guan Hui , Ma Jiabin , Wang Wenhui , Jing Shen , Miao Zheng , Zhang Fuquan , Liu Zhikai 
Published: October 2021

Abstract
Background: Neuroblastoma is a common extracranial malignant tumor in children. Its main treatment modality is a combination of chemotherapy, radiotherapy, and surgery. Given the advances in chemotherapy regimens and the widespread use of bone marrow transplantation over the decades, there has been improvement in treatment efficacy, which has led to prolonged patient survival. Accordingly, long-term complications have become a growing concern among physicians and patients. This study aimed to analyze the survival rate of patients with neuroblastoma and the risk factors for developing second malignant neoplasms (SMNs).Methods: The SEER 18 Regs (1973-2015) and SEER 9 Regs (1973-2015) data of the Surveillance, Epidemiology, and End Results (SEER) database of the US National Cancer Institute were adopted for survival and SMN analysis.Results: The 5-, 10-, and 20-year overall survival rates of patients with neuroblastoma were 67%, 65%, and 62%, respectively. Among 38 patients with neuroblastoma who presented with SMNs, those with abdomen as the primary site accounted for the majority (63.2%), followed by those with thorax (26.3%) and other sites (10.5%). SMNs occurred more commonly in non-specific neuroblastoma (incidence: 0.87%) than ganglioneuroblastoma (incidence: 0.3%). Compared with the general population, the risk of SMN is significantly higher (SIR=4.36). The risk of developing SMNs was significantly higher in the digestive system (SIR =7.29), bones and joints (SIR = 12.91), urinary system (SIR = 23.48), brain and other nervous systems (SIR = 5.70), and endocrine system (SIR = 5.84). Multivariate analysis revealed that the year of diagnosis (OR=2.138, 95%CI=1.634-2.797, p＜0.001) was the only independent risk factor for developing SMNs.Conclusion: This study identifies the risk factor for developing SMNs in patients with neuroblastoma, which could facilitate individualized screening for high-risk patients, to allow early diagnosis and treatment of SMNs.
Identification of Recurrent Genetic Patterns From Targeted Sequencing Panels With Advanced Data Science: A Case-Study On Sporadic And Genetic Neurodegenerative Diseases
Authors: Tarozzi Martina , Bartoletti-Stella Anna , Dall'Olio Daniele , Matteuzzi Tommaso , Baiardi Simone , Parchi Piero , Castellani Gastone , Capellari Sabina 
Published: October 2021

Abstract
BACKGROUND: Targeted Next Generation Sequencing is a common and powerful approach used in both clinical and research settings. However, at present, a large fraction of the acquired genetic information is not used since pathogenicity cannot be assessed for most variants. Further complicating this scenario is the increasingly frequent description of a poli/oligogenic pattern of inheritance showing the contribution of multiple variants in increasing disease risk. We present an approach in which the entire genetic information provided by target sequencing is transformed into binary data on which we performed statistical, machine learning, and network analyses to extract all valuable information from the entire genetic profile. To test this approach and unbiasedly explore the presence of recurrent genetic patterns, we studied a cohort of 112 patients affected either by genetic Creutzfeldt-Jakob (CJD) disease caused by two mutations in the PRNP gene (p.E200K and p.V210I) with different penetrance or by sporadic Alzheimer disease (sAD).RESULTS: Unsupervised methods can identify functionally relevant sources of variation in the data, like haplogroups and polymorphisms that do not follow Hardy-Weinberg equilibrium, such as the NOTCH3 rs11670823 (c.3837+21T>A). Supervised classifiers can recognize clinical phenotypes with high accuracy based on the mutational profile of patients. In addition, we found a similar alteration of allele frequencies compared the European population in sporadic patients and in V210I-CJD, a poorly penetrant PRNP mutation, and sAD, suggesting shared oligogenic patterns in different types of dementia. Pathway enrichment and protein-protein interaction network revealed different altered pathways between the two PRNP mutations.CONCLUSIONS: We propose this workflow as a possible approach to gain deeper insights into the genetic information derived from target sequencing, to identify recurrent genetic patterns and improve the understanding of complex diseases. This work could also represent a possible starting point of a predictive tool for personalized medicine and advanced diagnostic applications.
Lateral Ground Spread at Kausaltar, Kathmandu that Appeared in the 2015 Gorkha Earthquake
Authors: Shiga Masataka , Konagai Kazuo , Pokhrel Rama Mohan , Ikeda Takaaki 
Published: October 2021

Abstract
The April 25, 2015 Gorkha earthquake jolted the central region of Nepal causing extensive damage to buildings and earthen structures in both mountainous and urban areas of Nepal. Kathmandu-Bhaktapur road, one section of the Araniko Highway, crosses a small valley in the center of the Kathmandu Basin with an embankment. This embankment and adjacent area were deformed in the earthquake. To examine the cause of this ground deformation, several in-situ tests such as micro-tremor measurements, standard penetration tests (SPT), multi-channel analyses of surface waves (MASW), and C 14 dating were conducted. These tests show that a silty sand layer with low plasticity has most likely been liquefied 5 to 8 meters underground. It is also shown that groundwater lowering using existing wells can decrease the liquefaction-prone area by 81%.
Alleviating Effect of Quinoa and Underlying Mechanism on Hepatic Steatosis in High Fat Diet Fed Rat
Authors: Song Chenwei , Lv Wei , Li Yahui , Nie Pan , Lu Jun , Geng Yanlou , Heng Zhang , song Lihua 
Published: October 2021

Abstract
Background: HF diet-associated fatty liver (is also known as non-alcoholic fatty liver disease, NAFLD) is considered the hepatic component of the metabolic syndrome and has attracted widespread attention due to the increase in its prevalence. Daily dietary management, is considered to be one of the effective strategies for the prevention of NAFLD. In the present study, the effect of quinoa on the hepatic steatosis and the metabolism mechanism were investigated.Methods: Male SD rats simultaneously administered an HF diet and different amounts of quinoa (equivalent to 100 g/day and 300 g/day of human intake, respectively). After 12 weeks of the intervention, Hepatic TG and TC as well as serum anti-oxidative parameters were determined, H&E staining evaluated the hepatic steatosis. Differential metabolite in serum and hepatic tissue were analyzed using UPLC-QTOF-MSE. mRNA expression profile were investigated using RNA-Seq and further verified using real-time RT-PCR.Results: It showed that quinoa effectively controlled the weight of rats, mitigated hepatic steatosis and oxidative stress, which exhibited the beneficial effect of quinoa on prevention of NAFLD. These beneficial effects could be attributed to the regulation of the production of certain metabolites in the circulation system or liver such as LysoPC and PC. The RNA-Seq analysis and RT-PCR verification revealed that an intake of a high amount of quinoa more effectively up-regulated the genes related to lipid metabolism [Apoa (apolipoprotein)5, Apoa4, Apoc2) and down-regulated the genes related immune response [lrf (interferon regulatory factor)5, Tlr6 (Toll like receptor), Tlr10, Tlr11, Tlr12]. Conclusions: Quinoa could alleviate hepatic steatosis due to the regulation of metabolism and the expression of genes related with lipid metabolism and immune response.