bluuebunny/crossref_metadata_2025_split huggingface dataset:
PP353 Patient-Reported Outcomes: What Matters For Brazilian Breast Cancer Patients?
Authors: Silva Aline Silveira , França Ana , Padilla Matheus Piccin , Macedo Luana Schroeder , Magliano Carlos , Santos Marisa 
Published: December 2021

IntroductionPatient-Reported Outcomes (PRO) are directly reported by the patient without interpretation of the patient's response by a clinician or anyone else and pertains to the patient's health, quality of life, or functional status associated with health care or treatment. It can provide patients’ perspectives regarding treatment benefit and harm, directly measure treatment benefit and harm beyond survival, and are often the outcomes of most importance to patients. This study aims to analyze outcomes reported by Brazilian women diagnosed with breast cancer and rank the most important attributes for these patients.MethodsObservational study composed of interviews and questionnaires applied to a convenience sample of women diagnosed with breast cancer. The instruments were developed taking into account the literature on the topic and the expertise of specialists. The questionnaire was built with close-ended questions using multiple-choice and a Likert scale, in order to rank the attributes and outcomes found in the interviews.ResultsThe total sample was composed of 65 women diagnosed with breast cancer. Twelve women were interviewed, in September 2020, to explore the main outcomes and preferences about their treatments, such as the most common side effects and the most impacted aspects of life after diagnosis and breast cancer treatment. Psychological, emotional, and sexual impacts were frequently described as aspects of life affected by the disease and its treatment. Fifty-three women, from all the five Brazilian regions, answered the survey applied in October and November 2020. Following an order of importance ranking, the following outcomes were chosen, respectively: overall survival, progression-free survival; and quality of life. The treatment effects that were considered less important, among this sample, were pain and adverse events.ConclusionsThinking about expanding the therapeutic quality of users, it is essential to take into account the experiences of patients. PRO is a trend in current research to achieve this goal, in order to influence the decisions of HTA agencies about the importance of valuing outcomes that affect patients' lives.
Closest conjunct agreement with attributive adjectives
Authors: An Aixiu , Abeillé Anne 
Published: December 2021

AbstractContrary to most French grammars claiming that French only allows masculine agreement when mixed-gender nouns are conjoined, we show that closest conjunct agreement (CCA) does exist in contemporary French, as in other Romance languages, and is the preferred strategy for prenominal adjectives. Using data from a large corpus (FrWac) and an acceptability rating experiment, we show that (feminine) CCA is well accepted in contemporary French, and should be distinguished from attraction errors, despite the norm prescribing masculine agreement. We also show the role of the adjective position, i.e. prenominal or post-nominal, and humanness. CCA is the preferred strategy for prenominal adjectives, and non-human nouns favour CCA for post-nominal adjectives. Assuming a hierarchical structure for coordination, the closest noun is the highest in A-N order, whereas it is the lowest in N-A order. Thus CCA in prenominal position may be favoured by a shorter structural distance. One can also see CCA with a prenominal adjective as ‘early’ agreement. Regarding humanness, grammatical gender is interpreted as social gender with human nouns, and a masculine plural can refer to a mixed group. This ‘gender neutral’ plural may favour masculine agreement for human nouns, or the prescriptive norm is more influential for human nouns.
Aleutian Tern Onychoprion aleuticus abundance estimates at four globally significant colonies
Authors: RENNER HEATHER , RENNER MARTIN , LYONS DON , ZYKOV VLADIMIR , REVYAKINA ZOYA , OEHLERS SUSAN 
Published: December 2021

Summary
Aleutian Tern Onychoprion aleuticus numbers have been in steep decline at known Alaskan breeding colonies in recent decades (IUCN recently uplisted to ‘Vulnerable’). Available data suggest that most of the species may currently breed in Russia. Efforts to document global abundance and trends have been hampered by remoteness of colonies, lack of a formal monitoring programme, and the absence of reproducible population estimates with quantifiable errors, especially for large colonies. We surveyed four historically large colonies in Russia (2018) and Alaska (2019), which together may comprise 30–50% of the global breeding population. At each colony we obtained high resolution aerial photographs using a small Unmanned Aircraft System (sUAS). The large size of the colonies and the minimum altitude required to identify terns made it impractical to collect imagery of the entire colony. Instead, we employed a sampling approach, with sample locations selected based on spatially balanced acceptance sampling. Statistically sampled, low altitude sUAS images provided a fast, reproducible, and rigorous count of abundance for geographically large colonies, with low disturbance, and were generally consistent with concurrent ground-based observations. Concurrence among observers in photo counts indicated high precision in counts of attending birds and unattended nests, although species attribution in mixed tern colonies remains a source of significant uncertainty. Our results indicate that the four colonies surveyed here together supported <2,500 pairs of Aleutian Terns in the survey years. None of the colonies approached their peak size reported previously, likely due to recent predation, long-term decline, cold early season weather, or other factors. If these reduced colony sizes are representative of the current conditions, the implications for the global population would be dire.
Proposed multidimensional pain outcome methodology to demonstrate analgesic drug efficacy and facilitate future drug approval for piglet castration
Authors: Baysinger Angela , Webb Sherrie R. , Brown Jennifer , Coetzee Johann F. , Crawford Sara , DeDecker Ashley , Karriker Locke A. , Pairis-Garcia Monique , Sutherland Mhairi A. , Viscardi Abbie V. 
Published: December 2021

AbstractCastration of male piglets in the United States is conducted without analgesics because no Food and Drug Administration (FDA) approved products are labeled for pain control in swine. The absence of approved products is primarily due to a wide variation in how pain is measured in suckling piglets and the lack of validated pain-specific outcomes individually indistinct from other biological responses, such as general stress or inflammation responses with cortisol. Simply put, to measure pain mitigation, measurement of pain must be specific, quantifiable, and defined. Therefore, given the need for mitigating castration pain, a consortium of researchers, veterinarians, industry, and regulatory agencies was formed to identify potential animal-based outcomes and develop a methodology, based on the known scientific research, to measure pain and the efficacy of mitigation strategies. The outcome-based measures included physiological, neuroendocrine, behavioral, and production parameters. Ultimately, this consortium aims to provide a validated multimodal methodology to demonstrate analgesic drug efficacy for piglet castration.Measurable outcomes were selected based on published studies suggesting their validity, reliability, and sensitivity for the direct or indirect measurement of pain associated with surgical castration in piglets. Outcomes to be considered are observation of pain behaviors (i.e. ethogram defined behaviors and piglet grimace scale), gait parameters measured with a pressure mat, infrared thermography of skin temperature of the cranium and periphery of the eye, and blood biomarkers. Other measures include body weight and mortality rate.This standardized measurement of the outcome variable's primary goal is to facilitate consistency and rigor by developing a research methodology utilizing endpoints that are well-defined and reliably measure pain in piglets. The resulting methodology will facilitate and guide the evaluation of the effectiveness of comprehensive analgesic interventions for 3- to 5-day-old piglets following surgical castration.
Maternal high-fat diet consumption programs male offspring to mitigate complications in liver regeneration
Authors: Fante T. , Simino L. A. P. , Fontana Marina Figueiredo , Reginato Andressa , Ramalheira Thomaz Guadagnini , Rodrigues Hosana Gomes , Lisboa Patricia Cristina , de Moura Egberto Gaspar , Ignácio-Souza Leticia Martins , Milanski Marciane , Torsoni Marcio Alberto , Torsoni Adriana Souza 
Published: December 2021

AbstractIn the last decades, obesity and nonalcoholic fatty liver disease (NAFLD) have become increasingly prevalent in wide world. Fatty liver can be detrimental to liver regeneration (LR) and offspring of obese dams (HFD-O) are susceptible to NAFLD development. Here we evaluated LR capacity in HFD-O after partial hepatectomy (PHx). HFD-O re-exposed or not to HFD in later life were evaluated for metabolic parameters, inflammation, proliferation, tissue repair markers and survival rate after PHx. Increasing adiposity and fatty liver were observed in HFD-O. Despite lower IL-6 levels, Ki67 labeling, cells in S phase and Ciclin D1/PCNA protein content, a lower impact on survival rate was found after PHx, even when re-exposed to HFD. However, no difference was observed between offspring of control dams (SC-O) and HFD-O after surgery. Although LR impairment is dependent of steatosis development, offspring of obese dams are programmed to be protected from the damage promoted by HFD.
Rayleigh‐Love Discrepancy Highlights Temporal Changes in Near‐Surface Radial Anisotropy After the 2004 Great Sumatra Earthquake
Authors: Yu W. , Song T.‐R. A. , Su J. , Lin J.‐T. 
Published: December 2021

AbstractStrong ground motions from large earthquakes are capable of damaging near‐surface sediments and promoting notable reductions in their seismic velocity structures. These velocity reductions can be monitored using either body waves or surface waves from repeatable seismic sources, such as repeating earthquakes (REs) or ambient seismic noise. Here, we compile a decade‐long catalog of REs since the 2004 Mw 9.2 Sumatra Earthquake, and monitor the temporal velocity changes from Rayleigh waves (δVLR) and Love waves (δVLQ). We observe a δVLR of −0.16% and δVLR/δVLQ ratio of ∼6, inconsistent with velocity reductions in isotropic media. To reconcile the observations, we carry out analyses of sensitivity kernels of surface waves in isotropic and vertical transversely isotropic (VTI) media and forward waveform modeling. The modeling reveals that the observed large δVLR/δVLQ ratio can be explained by strong dβV (−4%) and weak dβH (−0.615%) reductions and an increase in radial anisotropy in the near surface. These changes are best explained by a 2% increase in crack density of aligned horizontal cracks in overpressured sediments near the compressive subduction zone forearc. Temporal variations of δVLR/δVLQ ratios and radial anisotropy after consecutive great earthquakes are consistent with laboratory experiments under cyclic loading and unloading.
Climate Response to Latitudinal and Altitudinal Distribution of Stratospheric Sulfate Aerosols
Authors: Zhao Mengying , Cao Long , Bala Govindasamy , Duan Lei 
Published: December 2021

AbstractStratospheric aerosol injection is one of the most widely studied solar radiation modification methods to reduce some effects of anthropogenic warming. We perform idealized simulations to analyze climate response to different latitudinal and altitudinal distributions of additional stratospheric sulphate aerosols. We analyze climate response to both large volcanic‐size aerosols that are representative of sulphate aerosols which form when SO2 is injected into the stratosphere by major volcanic eruptions or by proposed stratospheric sulphate aerosol geoengineering option, and small background‐size aerosols which are present in the stratosphere during quiescent periods with no major volcanic eruptions. Our simulations show that under the climate state with doubled atmospheric CO2, for the same total mass, independent of size‐distributions, aerosols concentrated at higher latitudes produce less negative effective radiative forcing but larger surface cooling as a result of larger forcing efficacy. For the same latitudinal distribution, small background‐size aerosols added at lower altitudes cause larger surface cooling as a result of hygroscopic growth that increases scattering of sunlight. In contrast, large volcanic‐size aerosols added at lower altitudes cause smaller surface cooling than at higher altitudes as a result of enhanced stratospheric heating and associated water vapor feedback that enhance absorption of solar and terrestrial radiation. For both background‐size and volcanic‐size aerosols, asymmetric distributions about the equator induce substantial cross‐equatorial energy transport, causing the Intertropical Convergence Zone to move to the warmer hemisphere with less aerosol loading. Our study helps to understand the climate consequences of different spatial patterns and size distributions of stratospheric aerosol perturbation.
Influence of Spatial Rainfall Gradients on River Longitudinal Profiles and the Topographic Expression of Spatially and Temporally Variable Climates in Mountain Landscapes
Authors: Leonard Joel S. , Whipple Kelin X. 
Published: December 2021

AbstractMountain landscapes have dynamic climates that, together with tectonic processes, influence their topographic evolution. Spatial and temporal variations in rainfall are ubiquitous in these settings as orographic precipitation patterns evolve with climate change and topography. Despite important implications such changes have for river incision, their influence is understudied. Here, we investigate how changes in rainfall pattern should affect both the steady state form and transient evolution of river profiles at the catchment scale using the stream power model. We find that spatially varied rainfall patterns can complicate steady state relationships between mean rainfall, channel steepness and fluvial relief, depending on where rainfall is concentrated in catchments, and lead to unexpected transient behavior if they are neglected. Specifically, changes in rainfall pattern cause multi‐stage transient responses that differ from responses to uniform changes in rainfall. Disparate responses by rivers that experience different rainfall conditions, particularly trunk and tributary rivers, are also an important factor in understanding catchment‐wide responses to climate change. Accounting for such disparities in sampling strategies and topographic analyses may, therefore, be vital for detecting and quantifying climate's role in landscape evolution. Lastly, we show how explicitly accounting for rainfall patterns in channel steepness indices, and thus spatial variations in erosional efficiency, may advance understanding of landscape sensitivity to climate. These results have important implications for detecting transient responses to changes in rainfall pattern (and more broadly climate), interpretation of morphometrics in steady state and transient landscapes, and quantifying the sensitivity of landscapes and erosion rates to climate.
The Prediction of Day‐to‐Day Occurrence of Low Latitude Ionospheric Strong Scintillation Using Gradient Boosting Algorithm
Authors: Zhao Xiukuan , Li Guozhu , Xie Haiyong , Hu Lianhuan , Sun Wenjie , Yang Sipeng , Li Yi , Ning Baiqi , Takahashi Hisao 
Published: December 2021

AbstractIonospheric scintillations caused by equatorial plasma bubbles (EPBs) can seriously affect various high technology systems based on Global Navigation Satellite System (GNSS) signals at equatorial and low latitudes. A reliable prediction of ionospheric scintillation occurrence is critical to relieve the effect. Using the long‐term ground‐based GNSS receiver and ionosonde data collected in the Brazilian longitude sector during 2012–2020, an ionospheric strong scintillation prediction model based on the gradient boosting algorithms extreme gradient boosting (XGBoost), light gradient boosting machine (LightGBM), and CatBoost is created and tested. It is for the first time that the XGBoost, LightGBM, and CatBoost are utilized to predict the day‐to‐day occurrence of regional ionospheric scintillation during post‐sunset hours. The relative importance of different parameters affecting EPB/scintillation occurrence for building the prediction model is examined. A comparison of daily scintillation occurrence from the modeled and observed results during 2014 (solar maximum) and 2020 (solar minimum) shows that the gradient boosting algorithms are effective for predicting strong scintillations over low latitude, with a prediction accuracy of ∼85%. The results suggest that the trained model with input of total electron content, equatorial F layer peak height and critical frequency before sunset could be well employed to predict the occurrence/nonoccurrence of intense scintillations over low latitude after sunset on a daily basis.
Quantifying Hydraulic Roughness From Field Data: Can Dune Morphology Tell the Whole Story?
Authors: de Lange S. I. , Naqshband S. , Hoitink A. J. F. 
Published: December 2021

AbstractHydraulic roughness is a fundamental property in river research, as it directly affects water levels, flow strength and the associated sediment transport rates. However, quantification of roughness is challenging, as it is not directly measurable in the field. In lowland rivers, bedforms are a major source of hydraulic roughness. Decades of research have focused on dunes to allow parameterization of roughness, with relatively little focus on field verification. This study aims to establish the predictive capacity of current roughness predictors, and to identify reasons for the unexplained part of the variance in roughness. We quantified hydraulic roughness based on the Darcy‐Weisbach friction factor (f) calculated from hydraulic field data of a 78 km‐long trajectory of the river Rhine and river Waal in the Netherlands. This is compared to predicted roughness values based on dune geometry, and to the spatial trends in the local topographic leeside angle, both inferred from bathymetric field data. Results from both approaches show the same general trend and magnitude of roughness values (0.019 < f < 0.069). Roughness inferred from dune geometry explains at best 31% of the variance. Efforts to explain the remaining variance from statistics of the local topographic leeside angles, which supposedly control flow separation, were unsuccessful. Unexpectedly, multi‐kilometer depth oscillations explain 34% of the total roughness variations. We suggest that flow divergence associated with depth increase causes energy loss, which is reflected in an elevated hydraulic roughness. Multi‐kilometer depth variations occur in many rivers worldwide, which implies a cause of flow resistance that needs further study.
Stochastic Decadal Projections of Colorado River Streamflow and Reservoir Pool Elevations Conditioned on Temperature Projections
Authors: Woodson David , Rajagopalan Balaji , Baker Sarah , Smith Rebecca , Prairie James , Towler Erin , Ge Ming , Zagona Edith 
Published: December 2021

AbstractDecadal (∼10‐year)‐scale flow projections in the Colorado River Basin (CRB) are increasingly important for water resources management and planning of its reservoir system. Physical models, ensemble streamflow prediction (ESP), do not have skill beyond interannual time scales. However, Global Climate Models have good skill in projecting decadal temperatures. This, combined with the sensitivity of CRB flows to temperature from recent studies, motivate the research question, can skill in decadal temperature projections be translated to operationally skillful flow projections and consequently, water resources management? To explore this, we used temperature projections from the Community Earth System Model‐Decadal Prediction Large Ensemble (CESM‐DPLE) along with past basin runoff efficiency as covariates in a Random Forest (RF) method to project ensembles of multiyear mean flow at the key aggregate gauge of Lees Ferry, Arizona. RF streamflow projections outperformed both ESP and climatology in a 1982–2017 hindcast, as measured by ranked probability skill score. The projections were disaggregated to monthly and subbasin scales to drive the Colorado River Mid‐term Modeling System (CRMMS) to generate ensembles of water management variables. The projections of pool elevations in Lakes Powell and Mead, the two largest U.S. reservoirs that are critical for water resources management in the basin, were found to reduce the hindcast median root mean square error by up to −20% and −30% at lead times of 48 and 60 months, respectively, relative to projections generated from ESP. This suggests opportunities for enhancing water resources management in the CRB and potentially elsewhere.
Curved display based on programming origami tessellations
Authors: Deng Yang , Liu Weixuan , Cheung Yik Kin , Li Yongkai , Hong Wei , Yu Hongyu 
Published: December 2021

AbstractCurved displays have recently become very popular, with wide applications for both industry and consumers. However, built upon initially flat films, most flexible displays are often incompatible with general nondevelopable surfaces. In this paper, we report a method for producing curved displays of nondevelopable shapes by using a structure-mechanics-inspired functional optimization method to design tessellation patterns that fold into the desired shapes. Representative displays in spherical and saddle shapes are demonstrated. The microfabrication process is employed for manufacturing 2D flexible foldable circuit boards, pick-and-place technology is used for placing illuminant elements onto the boards, and mold guidance is used for folding 2-D sheets into curved 3D display prototypes. The proposed technology is feasible for mass production and advances the application of next-generation curved displays.