bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of the Chances of Death in Covid-19 Data Using the Poisson Process
Authors: Ashgi Rizky , Supian Sudradjat , Subiyanto Subiyanto 
Published: January 2021

Covid-19 has brought about major changes for all people in various countries, for example creating vaccines, wearing masks and predicting the predictive state of death that will occur. In this paper, we will predict cases of covid-19 deaths using data taken from the worldometer website by taking data on daily covid-19 deaths worldwide in the period January 23rd- April 16th, 2020. Then the data is processed using the Poisson process that has been transformed using SPSS computer programming, namely the daily mortality rate in the period January 23rd - March 16th, 2020 using descriptive statistics, it was found that the death rate was 4 people in one day, then the Kolmogorov test followed the Poisson distribution, because it met the requirements for the P-value. value . Furthermore, it is calculated by using the death process, which is the chance of an event with the chance of death of all the corona suspects in the next 5 days, namely April 21 because the data has been transformed, so . the chance that no one will die within the next 45 days, namely April 30th, 2020 is close to. In the period of JanuaryÂ 23rdÂ - April 16th, 2020 using descriptive statistics, it was found that the death rate was 6 people in one day, then the Kolmogorov test was carried out with the results following the Poisson distribution, because it fulfilled the requirements for a P-value . Furthermore, it is calculated using the death process, which is the chance of an event with the chance of death of all the corona suspects in the next 5 days, namely April 21st, 2020Â because the data has been transformed, so . The chance that no one will die within the next 45 days, namely May 31, is close to .
Diagnostic performance of wireless fractional flow reserve: a meta-analysis
Authors: Pan Wen , Liu Qing-Jun 
Published: January 2021

IntroductionThe aim of this study was to evaluate diagnostic performance of wireless fractional flow reserve (FFR) used in patients with coronary artery disease (CAD).Material and methodsPubMed, Cochrane Library, Embase and Clinical trial.gov databases were searched by computer search and manual retrieval. The search terms included fractional flow reserve, quantitative coronary angiography, computational fluid dynamics and coronary artery disease. The meta-analysis was conducted with Stata12.0. Clinical outcomes included accuracy, sensitivity, specificity, positive likelihood ratio (+LR), negative likelihood ratio (–LR), diagnostic odds ratio (DOR) and area under the receiver operating curve.ResultsNine studies comprising 2052 vessels were included in the present meta-analysis. The sensitivity, specificity, +LR, –LR, DOC and accuracy were 87% (95% CI: 83–94%), 88% (95% CI: 82–92%), 7.28 (95% CI: 4.78–11.08), 0.14 (95% CI: 0.10–0.21), 50.69 (95% CI: 25.22–101.88) and 0.94 (95% CI: 0.91–0.96) respectively. No significant publication bias was detected.ConclusionsThis meta-analysis suggests that the clinical performance such as accuracy, sensitivity and specificity of wireless FFR is good to detect stenotic lesions with pressure-wire measured FFR as a reference.
Determination of multiple vitamins in 178 patients undergoing chemotherapy for lung cancer
Authors: liang lanqing , yu wei , cai boning , wang qianqian , huang xiang , chen jing , zeng mingyue , wang yao , qu baolin , liu fang 
Published: January 2021

IntroductionThe aim of the study was to investigate the changes in serum concentrations of nine vitamins in patients undergoing chemotherapy for lung cancer and explore their clinical values and influencing factors.Material and methodsPatients receiving chemotherapy for lung cancer in our centre from February 2018 to May 2020 were enrolled in this study. Serum concentrations of the nine vitamins including vitamins A, D, E, B9, B12, B1, C, B2, and B6 were measured in all subjects, and the changes in the concentrations of these vitamins were compared before and after 2 cycles of chemotherapy. In addition, the potential correlations of serum vitamin levels with age, gender, pathological type, and disease status were analysed.ResultsIn the 178 patients with lung cancer, there were different degrees of vitamin A, vitamin D, vitamin C, and in particular, vitamin B2 deficiencies. Before chemotherapy, the concentrations of vitamin A and vitamin C were significantly different between males and females and among patients in different clinical stages (both p < 0.05), the concentrations of vitamin C and vitamin B2 significantly differed among different pathological types of lung cancer (p < 0.05), and vitamin D level was significantly related to the disease status (p < 0.05). In addition, the proportion of vitamin B2 deficiency differed significantly among different pathological types (p < 0.05). There were significant differences in the concentrations of vitamins D, C, and B2 before and after chemotherapy (all p < 0.05). There was a correlation between the change of serum vitamin B1 concentration before and after chemotherapy and the change of body mass index (p < 0.05).ConclusionsDuring chemotherapy, lung cancer patients are more likely to develop vitamins A, D, C, and B2 deficiencies. Different vitamin deficiencies are related to gender, clinical stage, pathological type, and disease status. Vitamin determination and reasonable supplementation of nutrients in patients undergoing chemotherapy for lung cancer can help improve the nutritional status and increase chemotherapy tolerance.
Factors associated with gastro-duodenal ulcer in compensated type 2 diabetic patients: a Romanian single-center study
Authors: Negovan Anca , Banescu Claudia , Pantea Monica , Simona Bataga , Mocan Simona , Iancu Mihaela 
Published: January 2021

IntroductionIntroduction: Helicobacter pylori infection is accepted as the leading cause of chronic gastritis, ulcer disease and gastric cancer, with an important impact on health care burden, especially in countries with a high prevalence of infection. The aim of the study was to investigate the influence of H. pylori infection, medication, associated medical conditions or social habits on endoscopic ulcer occurrence in the compensated type 2 diabetic population.Material and methodsTwo hundred and sixty type 2 diabetic patients investigated on endoscopy (57 patients with peptic ulcer and 203 controls) with a complete set of biopsies, demographic and medical data were enrolled.ResultsOn univariate regression analysis, H. pylori infection (42.1% vs. 35.5%, p = 0.359) or a history of peptic ulcer (61.4% vs. 61.6%, p = 0.981) was not a predictor for ulcer on endoscopy in the diabetic population, and heartburn was more frequent in diabetics without ulcer (21.2% vs. 8.8%, p = 0.033). Anemia was the best predictor for ulcer on endoscopy in both diabetics with (p < 0.001, OR: 4.77, 95% CI: 2.02–11.28) and without (p = 0.027, OR: 2.76, 95% CI: 1.10–6.91) chronic proton pump inhibitor (PPI) therapy. In diabetic patients on PPI more than 1 month anticoagulants – acenocoumarol or low-weight molecular heparin (p = 0.038, OR: 2.37, 95% CI: 1.04–5.40), low-dose aspirin 75–125 mg/day (p = 0.029, OR: 2.61, 95% CI: 1.08–6.28) and alcohol consumption (p = 0.015, OR: 2.70, 95% CI: 1.19–6.13) were predictors for ulcer on endoscopy.ConclusionsIn diabetic patients, anemia is the most important predictor for ulcer on endoscopy, but not H. pylori or digestive symptoms, while low-dose aspirin or anticoagulant therapy and alcohol consumption are the most important predictors for ulcer in diabetics on chronic proton pump inhibitor therapy.
NGHIÊN CỨU QUY TRÌNH TÁCH CHIẾT POLYSACCARIDE TỔNG TỪ THÂN CÂY SÂM XUYÊN ĐÁ (MYXOPYRUM SMILACIFOLIUM WALL. BLUME) VÀ ĐÁNH GIÁ HOẠT TÍNH CHỐNG OXY HÓA
Authors: Damaso Paulinea , Igbonekwu-udoji Reagan Jonasa , Lê Thị Thu Hiền , Lê Thu Thủy , Cao Hồng Lê , Lưu Hồng Sơn , Vi Đại Lâm , Nguyễn Thị Tình , Tạ Thị Lượng , Đinh Thị Kim Hoa 
Published: January 2021

Sâm xuyên đá (Myxopyrum smilacifolium (Wall.) Blume) là một dược liệu quý. Tuy nhiên quy trình tách chiết chưa được tối ưu hóa. Trong nghiên cứu này sâm xuyên đá được thu mua tại xã La Hiên, huyện Võ Nhai, tỉnh Thái Nguyên. Kết quả nghiên cứu đã xác định được điều kiện tách chiết polysaccaride tổng từ thân cây sâm xuyên đá: dung môi ethanol 85%, tỉ lệ nguyên liệu/dung môi là 1/15 (w/v), thời gian tách chiết là 120 phút, nhiệt độ 90oC. Quy trình tách chiết cho hàm lượng polysaccaride tổng số đạt 93,4 (mg/g), dịch chiết cho khả năng chống oxy hóa 109,14 (µg/ml).
NGHIÊN CỨU MÔI TRƯỜNG NHÂN GIỐNG CÂY BA KÍCH (MORINDA OFFICIANALIS HOW) BẰNG PHƯƠNG PHÁP NUÔI CẤY MÔ
Authors: Phạm Thùy Dung , Nguyễn Văn Giáp , Vũ Thị Mây , Phạm Thị Mai Trang 
Published: January 2021

Cây Ba kích (Morinda officianalis How) là cây thuốc quý trong y học cổ truyền. Củ của cây Ba kích được sử dụng rộng rãi như một loại dược liệu có tác dụng bổ thận âm, bổ thận dương, tăng cường gân cốt, tăng sức đề kháng, sức dẻo dai, khử phong thấp. Dịch chiết từ củ ba kích có tác dụng giảm huyết áp, tác dụng nhanh với các tuyến cơ năng, bổ trí não, giúp ăn và ngủ ngon (Hoàng Thị Thế và cs 2013).
Để đáp ứng nguồn giống cây Ba kích chất lượng cao, số lượng lớn, đòi hỏi phải có được phương pháp nhân giống nhanh, quy mô công nghiệp, vì vậy chúng tôi đã thực hiện nghiên cứu môi trường nhân giống cây Ba kích bằng phương pháp nuôi cấy mô. Kết quả nghiên cứu cho thấy: Môi trường thích hợp cho sự nhân nhanh chồi Ba kích là MS + 3,5 mg/l BAP + 0,2 mg/l IBA + 10 mg/l Riboflavin + 30g/l đường + 5g/l agar, hệ số nhân chồi đạt 10,14 lần. Môi trường thích hợp cho sự tạo rễ của chồi Ba kích là 1/2MS + 0,3 mg/l IBA + 30 g/l đường + 5 g/l agar + 0,4 g/l than hoạt tính, tỷ lệ chồi ra rễ đạt 100% và số rễ trung bình đạt 3,44 rễ/chồi. Tỷ lệ sống tại vườn ươm đạt 95,20%.
Monitoring surface deformation of deep salt mining in Vauvert (France), combining InSAR and leveling data for multi-source inversion
Authors: Furst Séverine Liora , Doucet Samuel , Vernant Philippe , Champollion Cédric , Carme Jean-Louis 
Published: January 2021

Abstract. The salt mining industrial exploitation located in Vauvert (France) has been injecting water at high pressure into wells to dissolve salt layers at depth.
The extracted brine has been used in the chemical industry for more than 30 years, inducing a subsidence of the surface.
Yearly leveling surveys have monitored the deformation since 1996.
This dataset is supplemented by synthetic aperture radar (SAR) images, and since 2015, global navigation satellite system (GNSS) data have also continuously measured the deformation.
New wells are regularly drilled to carry on with the exploitation of the salt layer, maintaining the subsidence.
We make use of this careful monitoring by inverting the geodetic data to constrain a model of deformation.
As InSAR and leveling are characterized by different strengths (spatial and temporal coverage for InSAR, accuracy for leveling) and weaknesses (various biases for InSAR, notably atmospheric, very limited spatial and temporal coverage for leveling), we choose to combine SAR images with leveling data, to produce a 3-D velocity field of the deformation.
To do so, we develop a two-step methodology which consists first of estimating the 3-D velocity from images in ascending and descending acquisition of Sentinel 1 between 2015 and 2017 and second of applying a weighted regression kriging to improve the vertical component of the velocity in the areas where leveling data are available.
GNSS data are used to control the resulting velocity field.
We design four analytical models of increasing complexity.
We invert the combined geodetic dataset to estimate the parameters of each model.
The optimal model is made of 21 planes of dislocation with fixed position and geometry.
The results of the inversion highlight two behaviors of the salt layer: a major collapse of the salt layer beneath the extracting wells and a salt flow from the deepest and most external zones towards the center of the exploitation.
Cement industry in Chile: CBB and its look to the future
Authors: Ángeles Briones , Oliva B. Ismael , Ramírez Hernández Karla 
Published: January 2021

In 2019, Cbb (previously known as Cementos Bío Bío) was one of the main companies dedicated to the production of cement, concrete and lime. It had the largest logistics coverage in Chile and the largest installed production capacity with 3.5 million tons of cement per year and a dispatch of 1.3 million tons. It employed more than 2,800 collaborators, of which 1,344 provided services as contractor companies. Its annual sales for 2019 had been 263,182 million pesos (MM $), which allowed it to generate a net operating result of MM $ 13,104 and an EBITDA of MM $ 36,321. Cbb had managed to position itself in the industry thanks to its long history in the market and its innovative vision in creating high quality products by reusing waste such as slag and ash.
Until 2010, the cement industry in Chile had had three major participants: Melón S.A., Cemento Polpaico S.A. and Cbb. All three companies operated under a traditional business model that ranged from the extraction of raw materials in their own mines to their dispatch. In 2011, Chile no longer only produced cement, but also imported it, as a result of low freight costs and lower cement prices due to overproduction in countries such as South Korea, China and Japan. These new conditions allowed other competitors to enter the industry with a different business model based on the import of cement for the production of concrete or the import of clinker (Substance obtained as a result of kiln calcination of limestone mixtures artificially prepared clays with the eventual addition of other materials) installing cement grinding plants. Clinker was one of the key raw materials that was in the middle of the cement production chain, which was obtained from the calcination of limestone. As clinker was imported, it was no longer necessary to have limestone mining deposits.
At the end of 2019, the General Manager, who had arrived at the company on January 1, 2018, had to propose to the Board of Directors the focuses to work to continue with the implementation of the Transforma 2021 Strategic Plan. The plan included a set of six initiatives with those seeking to renew the company given the changes that were already beginning to be reflected in lower financial performance. Two years after evaluating the implementation and results obtained, the General Manager sought to define the work focuses for each of the initiatives. Could changes in the industry affect a consolidated and long-standing company like Cbb? Where should you direct your effort to achieve the goals and expected results in the plan? Would the Transform 2021 Plan succeed in taking Cbb where they expected?
Economic Base Of Cooperation Development In Agrarian Product Market In Kyrgyz Republic
Authors: Maksimov Anatoly F. , Ten Anatoly D. 
Published: January 2021

The paper aims to describe the potential in building up the economic base of agricultural cooperation development in the Kyrgyz Republic, to propose an organisational and economic mechanism of cooperative relations in the Kyrgyz Republic, taking into account the complex development of agricultural production, logistics infrastructure and cooperation. Cooperation is viewed as an efficient economic mechanism to integrate small agricultural producers into the commodity distribution systems in the domestic and international agricultural food markets. Building on a review of sources describing the potential of cooperation in the modern environment, analyses of the agrarian structure and assessments of the economic base of cooperation, the paper proposes an organisational structure to navigate through the development of an effective agrarian structure, logistics infrastructure and cooperation in the Kyrgyz Republic.The paper is based on the materials from international development organisations, the National Statistical Committee of the Kyrgyz Republic and the findings of some researchers. The makings of the paper may be helpful summarising the international practice of development of cooperative relations, enhancement of institutional conditions and public policies of support of cooperation in the Kyrgyz Republic and should be of interest for a wide research audience in the area of agricultural cooperation.
Utilization of Orthobiologics by Sports Medicine Physicians: A Survey-based Study
Authors: Noback Peter C. , Donnelley Claire A. , Yeatts Nicholas C. , Parisien Robert L. , Fleischli James E. , Ahmad Christopher S. , Moorman Claude T. , Trofa David P. , Saltzman Bryan M. 
Published: January 2021

Introduction:
Investigations are rapidly increasing into products referred to as orthobiologics and their utility in the nonsurgical and surgical treatment of diverse orthopaedic pathology.

Methods:
Members (599) of the American Orthopaedic Society for Sports Medicine were sent a survey that assessed their usage, motivation for use, and perceived efficacy of the following orthobiologics: leukocyte-rich platelet-rich plasma, leukocyte-poor platelet-rich plasma (PRP-LP), bone marrow aspirate concentrate, amniotic membrane products, adipose-derived mesenchymal stromal cells, and umbilical cord–derived cells. Application of these orthobiologics for the following pathologies was assessed: osteoarthritis, muscle injuries, tendon injuries, ligament injuries, labral injuries, and focal articular cartilage tears.

Results:
The survey was completed by 165 respondents (27.5%), of which 66.1% reported using at least one orthobiologic in their practice. Orthobiologic users reported the following: 71.6% are increasing their use, and 23.9% advertise their use. PRP-LP is the most commonly used orthobiologic for 76.1%, with 30% of PRP-LP users reporting use due to competitor utilization. The pathology most commonly treated with orthobiologics is osteoarthritis, for 71.6% of users, who primarily use PRP-LP in the knee joint. Leukocyte-rich platelet-rich plasma is the most popular orthobiologic in muscle, ligament, tendon, and labral injuries, whereas bone marrow aspirate concentrate is most popular for focal articular cartilage injuries. Primary orthobiologic-eligible groups were adults and recreational noncompetitive athletes. More than half (>50%) of orthobiologic users perceived all but umbilical cord–derived cells to be efficacious.

Conclusion:
Orthobiologics are used by a significant number of sports medicine physicians and are likely increasing in popularity. Among orthobiologics, platelet-rich plasmas are the most popular, and osteoarthritis is the pathology most likely to be treated. Orthobiologics are sometimes used for reasons other than clinical efficacy, especially competitor utilization, and physicians are disparate in their application of these products.
Branded, co-packing of private label: slechts een kwestie van smaak?
Authors: Roscam Abbing Felix 
Published: January 2021

Branded, co-packing of private label: slechts een kwestie van smaak?
In dit artikel wordt een overzicht gegeven van de overwegingen die ten grondslag liggen aan de marktafbakening bij de productie van eigen merk (branded), co-packing (merk van een derde) en private label (huismerk). Hierbij zullen zaken en kernoverwegingen uit de beschikkingspraktijk van de Europese Commissie, de ACM en de Britse mededingingsautoriteit CMA worden besproken. Het artikel spitst zicht toe op overwegingen voor het upstream (productie)niveau aan de hand van beschikkingen inzake, met name, levensmiddelen.
Het Hongaarse banken-arrest: vlees doch vis en een eendentest voor doelbeperkingen
Authors: Elkerbout Ruben 
Published: January 2021

Het Hongaarse banken-arrest: vlees doch vis en een eendentest voor doelbeperkingen
Bespreking van het Hongaarse banken-arrest van het Hof van Justitie over het concept van de doelbeperking.
Merlin deficiency alters the redox management program in breast cancer
Authors: Mota Mateus , Metge Brandon J. , Hinshaw Dominique C. , Alsheikh Heba A. , Chen Dongquan , Samant Rajeev S. , Shevde Lalita A. 
Published: January 2021

The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues. In order to recapitulate clinical evidence, we generated a unique, conditional Nf2‐knockout (Nf2−/−) mouse mammary tumor model. Merlin‐deficient breast tumor cells and Nf2−/− mouse embryonic fibroblasts (MEFs) displayed a robustly invasive phenotype. Moreover, Nf2−/− MEFs presented with notable alterations in redox management networks, implicating a role for Merlin in redox homeostasis. This programmatic alteration resonated with pathways that emerged from breast tumor cells engineered for Merlin deficiency. Further investigations revealed that NF2‐silenced cells supported reduced activity of the Nuclear factor, erythroid 2 like 2 antioxidant transcription factor, concomitant with elevated expression of NADPH oxidase enzymes. Importantly, mammary‐specific Nf2−/− in an Mouse mammary tumor virus Neu + murine breast cancer model demonstrated accelerated mammary carcinogenesis in vivo. Tumor‐derived primary organoids and cell lines were characteristically invasive with evidence of a dysregulated cellular redox management system. As such, Merlin deficiency programmatically influences redox imbalance that orchestrates malignant attributes of mammary/breast cancer.
Comparison of separation methods for tissue‐derived extracellular vesicles in the liver, heart, and skeletal muscle
Authors: Matejovič Adam , Wakao Shohei , Kitada Masaaki , Kushida Yoshihiro , Dezawa Mari 
Published: January 2021

Extracellular vesicles (EVs), which are nanosized vesicles released by cells as intracellular messengers, have high potential as biomarkers. EVs are usually collected from in vitro sources, such as cell culture media or biofluids, and not from tissues. Techniques enabling direct collection of EVs from tissues will extend the applications of EVs. We compared methods for separating EVs from solid liver, heart, and skeletal muscle. Compared with a precipitation method, an ultracentrifugation‐based method for collection of EVs from solid tissues yielded a higher proportion of EVs positive for EV‐related markers, with minimum levels of intracellular organelle‐related markers. Some tissue‐specific modifications, such as a sucrose cushion step, may improve the yield and purity of the collected EVs.