bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid In Situ Ligand‐Exchange Process Used to Prepare 3D PbSe Nanocrystal Superlattice Infrared Photodetectors
Authors: Xu Xiaojie , Kweon Kyoung E. , Keuleyan Sean , Sawvel April , Cho En Ju , Orme Christine 
Published: May 2021

AbstractColloidal semiconductor nanocrystals are important building blocks for low‐cost, solution‐processed electronic devices with tunable functionalities. Considerable progress is made in improving charge transport through nanocrystal films by exchanging long insulating ligands with shorter passivating ligands. To take full advantage of this strategy, it is equally important to fabricate close‐packed structures that reduce the average interparticle spacing. Yet it remains a challenge to retain long‐range, close‐packed order after ligand exchange. Here, a novel one‐step in situ ligand‐exchange method is demonstrated that enables rapid (5 min) ligand exchange of nanocrystal films, which are more than 50 layers thick. Using this simple and efficient method, it is shown that the face‐centered cubic ordering of 500 nm thick PbSe nanocrystal films is retained after ligand exchange from oleic acid to benzoic acid. Moreover, it is demonstrated that PbSe nanocrystal photodetectors with a well‐ordered structure have superior optoelectronic properties compared to disordered films; ordered films have a 16× higher responsivity of ≈0.25 A W−1 at 1 V and a 2× faster response time. As far as it is known, this is the first report to realize a rapid one‐step ligand exchange through a thick superlattice film with retention of long‐range order.
All‐Conjugated Polymer Core–Shell and Core–Shell–Shell Particles with Tunable Emission Profiles and White Light Emission
Authors: Haehnle Bastian , Schuster Philipp A. , Chen Lisa , Kuehne Alexander J. C. 
Published: May 2021

AbstractFuture applications of conjugated polymer particles (CPP) in medicine, organic photonics, and optoelectronics greatly depend on high performance and precisely adjustable optical properties of the particles. To meet these criteria, current particle systems often combine conjugated polymers with inorganic particles in core–shell geometries, extending the possible optical characteristics of CPP. However, current conjugated polymer particles are restricted to a single polymer phase composed of a distinct polymer or a polymer blend. Here, a synthetic toolbox is presented that enables the synthesis of monodisperse core–shell and core–shell–shell particles, which consist entirely of conjugated polymers but of different types in the core and the shells. Seeded and fed‐batch dispersion polymerizations based on Suzuki–Miyaura‐type cross‐coupling are investigated. The different approaches allow accurate control over the created interface between the conjugated polymer phases and thus also over the energy transfer phenomena between them. This approach opens up completely new synthetic freedom for fine tuning of the optical properties of CPP, enabling, for example, the synthesis of individual white light‐emitting particles.
Experimental study of wind pressure fluctuating characteristics and wind load shape factor of long‐span cylinder roof structure
Authors: Wu Yanru , Wu Xiaohong , Wei Sitong , Sun Qing , Wang Jiantao 
Published: May 2021

SummaryThis paper comprehensively presents the results of a wind tunnel experiment of the wind pressure fluctuating characteristics of a long‐span roof structure, namely the fluctuating wind pressure coefficient (FWPC), wind pressure power spectrum, and wind pressure coherence. The variation trend of FWPCs in the wind directions of 0°, 45°, and 90° were analyzed in sealed and open conditions, as well as the fluctuating wind pressure coefficients of lateral and longitudinal profiles of roof. Subsequently, the models of wind pressure spectrum in different zones and the spatial coherence of fluctuating wind pressure at different wind angles were discussed. The zone values of wind load shape factors of envelope structure with sealed, open, and pile of coal in open were calculated by area weighted averaging. The results indicate that the sealed condition significantly influences the fluctuating characteristics on the roof surface more than the open condition, suggesting that the maximum varied gradient of FWPCs is achieved in the 45° wind direction. Further, different forms and peak frequencies of the wind pressure spectrum in the roof region developed three zones, revealing that the peak frequency in energy‐preserved, inertia, and energy‐dissipated regions show an increasing trend for the different directions. The spatial correlations of wind pressure between measurement taps decrease with the increase in the frequency and spatial distance. Moreover, the correlation coefficients are lower than 0.2 when the frequency was higher than 35 Hz, and a modified three‐dimensional spatial coherence function of wind pressure is proposed. In contrast to the sealed case, the zone values of wind load shape factors of envelope structure with open and pile of coal in open are alleviated due to the separation flows.
Stakeholders’ environmental preferences based corporate environmental information influencing factors research
Authors: Yi Liqi , Li Tao 
Published: May 2021

AbstractAttracted widespread attention from stakeholders, environmental information disclosed by companies can show the situations that corporates fulfill their environmental obligations. Different corporate stakeholders usually pay diverse attention to key environmental information factors due to their various industries, investment levels, identity characteristics, etc. However, the previous researches are not scientific enough due to the lack of reflecting the importance of environmental information according to the preferences of stakeholders. To fill this gap, this paper applies a fuzzy analysis model as the internal type‐2 trapezoidal fuzzy numbers —analytic hierarchy process (AHP) based ordinary least square regression to comprehensively reflect the preferences of stakeholders. Following that, this paper utilizes the data from 62 Chinese power companies as an example, and the results show that environmental information disclosed (EID) quality is positively correlated with regional economic development level and executive salary incentives. Moreover, the corporate political connection weakens the interaction between salary incentives and EID, which can be further confirmed by robustness analysis. Finally, this paper contributes to the literature on the research methods on EID by considering stakeholders’ preferences in the fuzzy environment.
Evaluation of the incorporation of charcoal residues in cement mortars
Authors: Reis Marielza Corrêa dos , Serra Sheyla Mara Baptista , Zampieron João Vicente 
Published: May 2021

AbstractIncorporating agroindustrial waste into cementitious composites can minimize natural resource consumption and decrease the construction industry's environmental impact. This paper aims to evaluate the potential of using charcoal residues (CR) to partially replace fine sand (by volume) on cementitious mortars’ properties. The microstructure and corresponding physicochemical compositions were determined with scanning electron microscopy (SEM), fluorescence, and X‐ray diffraction without prior processing. Test specimens were produced with CR in the contents of 0%, 10%, 20%, and 30% concerning fine sand. After the test specimens curing period, the axial compression strength, tensile strength by diametrical compression, and the SEM were combined with X‐ray dispersion spectrometry. The results showed that although the CR does not present themselves as pozzolanic materials, their incorporation around 20% showed mechanical resistance of 28 MPa, which is confirmed by the analysis of variance. Such results corroborate with research that confirms the feasibility of including these residues in cementitious matrices, adding value to the material.
Trophic state in a tropical lake based on Chlorophyll‐a profiler data and Sentinel‐2 images: The onset of an algal bloom event
Authors: Pantoja Diego A. , Vega‐Álvarez Néstor A. , Gasca‐Ortiz Tzitlali 
Published: May 2021

AbstractThe condition of Lake Zirahuén was evaluated before and after a significant algal bloom took place. The state of the lake was tracked using measurements of chlorophyll‐a concentration from a fluorometer attached to a conductivity, temperature, and depth (CTD) profiler and complemented with the use of satellite images from Sentinel‐2. It was found that the current state of the lake is in transition from an oligotrophic to a mesotrophic level with some evidence of deterioration, but still being considered as a clear lake. With the use of empirical algorithms to retrieve chlorophyll‐a from satellite data it was found that the images presented an acceptable feasibility (R2 = 0.64). The observed algal bloom was detected one month before the algae reached its major extent, being the reflectiveness of the green band a good indicator of the onset of the algal bloom event. Favorable conditions for the algal bloom were also recorded two months before its major extend through a chain of thermistors.Practitioner Points

The trophic state of Lake Zirahuén was evaluated before and after a significant algal bloom took place.
The lake is classified as being in transition from oligotrophic to mesotrophic. Nonetheless, it continues to have good clarity.
Satellite images improve in the description of the spatial‐temporal variability of the lake. In particular, the green band reflectiveness.
The r-Dowling–Lah Polynomials
Authors: Gyimesi Eszter 
Published: May 2021

AbstractThe notions of r-Bell polynomials and their generalization, the r-Dowling polynomials are due to Mező and Cheon, Jung. Recently, Nyul and Rácz defined the r-Lah polynomials, which are close relatives of r-Bell polynomials. In the present paper, we introduce the Dowling type generalization of r-Lah polynomials, the r-Dowling–Lah polynomials. We give a comprehensive study of them using the results of the author and Nyul on r-Whitney–Lah numbers, which are the coefficients of these polynomials.
Ileal pouch–anal anastomosis—a personal experience reevaluating complications, pouch survival, and quality of life
Authors: Ecker Nils Karl Josef , Woywod Ann-Christin , Ecker Karl-Wilhelm 
Published: May 2021

Abstract
Background
Ileal pouch–anal anastomosis (IPAA) is the gold standard for proctocolectomy. The present study evaluates surgical outcomes of the authors’ operations over a 30-year period, including pouch survival and quality of life (QOL).

Methods
Records of patients undergoing IPAA between 1986 and 2015 were retrospectively analyzed regarding early and late complications and pouch survival. An online survey assessed QOL.

Results
Of 119 patients, 84 had chronic inflammatory bowel disease (IBD) and 35 non-inflammatory bowel disease (non-IBD). Pouch construction was simultaneous with proctocolectomy in 69% and metachronous in 31%. Double-stapler anastomosis with purse string suture was performed in 100 patients. With temporary transanal decompression by catheter insertion in all patients, loop ileostomy (LIS) was selectively omitted in 68%. Three anastomotic insufficiencies occurred both without (4.4%) and with LIS (9.4%). Perioperative morbidity for LIS closure was substantial (33.3%). In the long-term course, 36 patients (30.5%) required revision (cumulative probability after 15 years: 59.1%). IPAA was discontinued in 16 patients (13.6%), reducing cumulative continence preservation to 72.9% after 15 years. By converting the pouch to a continent ileostomy (CI) in 6 patients with uncorrectable functional complications, cumulative pouch survival reached 81.8% after 27 years. The online survey revealed significant improvements in occupation, sports, and travel vs. before proctocolectomy, but no change in sexual life. Physical, psychological, and social scores were still below the age-matched norm values. Whereas >90% were satisfied with the surgical outcome, only 3/25 had no functional improvement requests.

Conclusion
IPAA in double-stapler technique is safe, even without protective LIS. However, short- and long-term morbidity is considerable, with a non-negligible risk of continence loss. Conversion to CI for purely functional complications can significantly reduce definite pouch failure. Despite patients’ high subjective satisfaction, QOL remains objectively compromised.
Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology
Authors: Gouveia-Freitas Kaylene , Bastos-Leite António J. 
Published: May 2021

AbstractPerivascular spaces (PVS) of the brain, often called Virchow-Robin spaces, comprise fluid, cells and connective tissue, and are externally limited by astrocytic endfeet. PVS are involved in clearing brain waste and belong to the “glymphatic” system and/or the “intramural periarterial drainage” pathway through the basement membranes of the arteries. Related brain waste clearance systems include the blood–brain barrier, scavenger cells, cerebrospinal fluid, perineural lymphatic drainage pathways and the newly characterised meningeal lymphatic vessels. Any functional abnormality of PVS or related clearance systems might lead to accumulation of brain waste. It has been postulated that PVS enlargement can be secondary to accumulation of β-amyloid. Lack of integrity of the vascular wall, microbleeds, cerebral amyloid angiopathy (CAA) and enlarged PVS often occur in the preclinical stages of Alzheimer’s disease, preceding substantial brain atrophy. PVS enlargement in the form of état criblé at the basal ganglia has also been considered to reflect focal atrophy, most probably secondary to ischaemic injury, based upon both pathological and imaging arguments. In addition, distinct topographic patterns of enlarged PVS are related to different types of microangiopathy: CAA is linked to enlarged juxtacortical PVS, whereas subjects with vascular risk factors tend to have enlarged PVS in the basal ganglia. Therefore, enlarged PVS are progressively being regarded as a marker of neurodegenerative and cerebrovascular pathology. The present review addresses the evolving concept of PVS and brain waste clearance systems, the potential relevance of their dysfunction to neurodegenerative and cerebrovascular pathology, and potential therapeutic approaches of interest.
Optimisation of xylanases production by two Cellulomonas strains and their use for biomass deconstruction
Authors: Ontañon Ornella M , Bedő Soma , Ghio Silvina , Garrido Mercedes M , Topalian Juliana , Jahola Dóra , Fehér Anikó , Valacco Maria Pia , Campos Eleonora , Fehér Csaba 
Published: May 2021

Abstract
One of the main distinguishing features of bacteria belonging to the Cellulomonas genus is their ability to secrete multiple polysaccharide degrading enzymes. However, their application in biomass deconstruction still constitutes a challenge. We addressed the optimisation of the xylanolytic activities in extracellular enzymatic extracts of Cellulomonas sp. B6 and Cellulomonas fimi B-402 for their subsequent application in lignocellulosic biomass hydrolysis by culture in several substrates. As demonstrated by secretomic profiling, wheat bran and waste paper resulted to be suitable inducers for the secretion of xylanases of Cellulomonas sp. B6 and C. fimi B-402, respectively. Both strains showed high xylanolytic activity in culture supernatant although Cellulomonas sp. B6 was the most efficient xylanolytic strain. Upscaling from flasks to fermentation in a bench scale bioreactor resulted in equivalent production of extracellular xylanolytic enzymatic extracts and freeze drying was a successful method for concentration and conservation of the extracellular enzymes, retaining 80% activity. Moreover, enzymatic cocktails composed of combined extra and intracellular extracts effectively hydrolysed the hemicellulose fraction of extruded barley straw into xylose and xylooligosaccharides.

Key points
• Secreted xylanase activity of Cellulomonas sp. B6 and C. fimi was maximised.
• Biomass-induced extracellular enzymes were identified by proteomic profiling.
• Combinations of extra and intracellular extracts were used for barley straw hydrolysis.
Transarterial Chemoembolization of Hepatocellular Carcinoma Using Radiopaque Drug-Eluting Embolics: Impact of Embolic Density and Residual Tumor Perfusion on Tumor Recurrence and Survival
Authors: Ruff Christer , Artzner Christoph , Syha Roland , Grosse Ulrich , Hoffmann Rüdiger , Bitzer Michael , Partovi Sasan , Horger Marius , Nikolaou Konstantin , Grözinger Gerd 
Published: May 2021

Abstract
Purpose
To evaluate the value of dual-phase parenchymal blood volume (PBV) C-arm mounted cone-beam-CT (CBCT) to enable assessment of radiopaque, doxorubicin-loaded drug-eluting embolics (rDEE) based on the visual degree of embolization, embolic density and residual tumor perfusion as early predictors for tumor recurrence after transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC).

Material and Methods
Thirty patients (50 HCCs) were prospectively enrolled, underwent cross-sectional imaging before and after TACE using 100–300 µm rDEE and had regular follow-up examinations. Directly before and after the TACE procedure, PBV-CBCT was acquired. The response was evaluated and compared to visual degree of embolization (DE) and embolic density (ED) of rDEE deposits, as well as the presence of residual tumor perfusion (RTP) derived from PBV-CBCT. Outcome was assessed by mid-term tumor response applying mRECIST and patient survival after 12 months.

Results
RTP was detected in 16 HCCs and correlated negatively with DE (p = .03*) and ED (p = .0009*). The absence of RTP significantly improved lesion-based mid-term response rates regarding complete response (CR, 30/34 (88%) vs 2/16 (12.5%), p = .0002*), lesion-based complete response rate was 75% (21/28) for DE ≥ 50% vs. 50% (11/22) for DE < 50% (p =  .08) and 82% (27/33) for ED ≥ 2 vs. 29% for ED < 2 (5/17), p =  .005*). Thirteen patients were treated with re-TACE within 12 months, 11 of which had shown RTP. 12-month survival rate was 93%.

Conclusion
Residual tumor perfusions as assessed by PBV-CBCT during rDEE-TACE proved to be the best parameter to predict mid-term response.
“Level of Evidence: Level 3”
Regulation of eosinophil functions by autophagy
Authors: Germic Nina , Hosseini Aref , Yousefi Shida , Karaulov Alexander , Simon Hans-Uwe 
Published: May 2021

AbstractEosinophils are granule-containing leukocytes which develop in the bone marrow. For many years, eosinophils have been recognized as cytotoxic effector cells, but recent studies suggest that they perform additional immunomodulatory and homeostatic functions. Autophagy is a conserved intracellular process which preserves cellular homeostasis. Autophagy defects have been linked to the pathogenesis of many human disorders. Evidence for abnormal regulation of autophagy, including decreased or increased expression of autophagy-related (ATG) proteins, has been reported in several eosinophilic inflammatory disorders, such as Crohn’s disease, bronchial asthma, eosinophilic esophagitis, and chronic rhinosinusitis. Despite the increasing extent of research using preclinical models of immune cell-specific autophagy deficiency, the physiological relevance of autophagic pathway in eosinophils has remained unknown until recently. Owing to the increasing evidence that eosinophils play a role in keeping organismal homeostasis, the regulation of eosinophil functions is of considerable interest. Here, we discuss the most recent advances on the role of autophagy in eosinophils, placing particular emphasis on insights obtained in mouse models of infections and malignant diseases in which autophagy has genetically dismantled in the eosinophil lineage. These studies pointed to the possibility that autophagy-deficient eosinophils exaggerate inflammation. Therefore, the pharmacological modulation of the autophagic pathway in these cells could be used for therapeutic interventions.
Performance of machine learning algorithms for glioma segmentation of brain MRI: a systematic literature review and meta-analysis
Authors: van Kempen Evi J. , Post Max , Mannil Manoj , Witkam Richard L. , ter Laan Mark , Patel Ajay , Meijer Frederick J. A. , Henssen Dylan 
Published: May 2021

Abstract
Objectives
Different machine learning algorithms (MLAs) for automated segmentation of gliomas have been reported in the literature. Automated segmentation of different tumor characteristics can be of added value for the diagnostic work-up and treatment planning. The purpose of this study was to provide an overview and meta-analysis of different MLA methods.

Methods
A systematic literature review and meta-analysis was performed on the eligible studies describing the segmentation of gliomas. Meta-analysis of the performance was conducted on the reported dice similarity coefficient (DSC) score of both the aggregated results as two subgroups (i.e., high-grade and low-grade gliomas). This study was registered in PROSPERO prior to initiation (CRD42020191033).

Results
After the literature search (n = 734), 42 studies were included in the systematic literature review. Ten studies were eligible for inclusion in the meta-analysis. Overall, the MLAs from the included studies showed an overall DSC score of 0.84 (95% CI: 0.82–0.86). In addition, a DSC score of 0.83 (95% CI: 0.80–0.87) and 0.82 (95% CI: 0.78–0.87) was observed for the automated glioma segmentation of the high-grade and low-grade gliomas, respectively. However, heterogeneity was considerably high between included studies, and publication bias was observed.

Conclusion
MLAs facilitating automated segmentation of gliomas show good accuracy, which is promising for future implementation in neuroradiology. However, before actual implementation, a few hurdles are yet to be overcome. It is crucial that quality guidelines are followed when reporting on MLAs, which includes validation on an external test set.

Key Points
• MLAs from the included studies showed an overall DSC score of 0.84 (95% CI: 0.82–0.86), indicating a good performance.
• MLA performance was comparable when comparing the segmentation results of the high-grade gliomas and the low-grade gliomas.
• For future studies using MLAs, it is crucial that quality guidelines are followed when reporting on MLAs, which includes validation on an external test set.