bluuebunny/crossref_metadata_2025_split huggingface dataset:
TO DETERMINE THE PREVALENCE OF LOW BONE MINERAL DENSITY (OSTEOPENIA AND OSTEOPOROSIS) IN INDIAN PATIENTS WITH CIRRHOSIS OF LIVER AWAITING LIVER TRANSPLANTATION AS PER CURRENTLY USED HOLOGIC DXA DATABASE
Authors: Deshmukh Sharad , Deshmukh Suchita , Parameswran Sarojni A , Pirmanayagam P , Murgan N , Patil Sangita 
Published: April 2021

Background: Abnormalities in the bone metabolism observed in chronic liver disease are referred to as hepatic osteodystrophy. Osteoporosis and osteopenia are each part of this condition. Both conditions have a significant impact on morbidity, causing fractures that may result in chronic pain, long-lasting immobility, and deformity. Prevalence of fracture in patients with liver transplantation ranges from 15% - 65%. A high rate of fracturing is seen within the initial 1–2 years after transplantation.
Aim: To determine the prevalence of low bone mineral density (osteopenia and osteoporosis) in Indian patients with cirrhosis of liver awaiting liver transplantation as per currently used Hologic DXA database
Methods: This was a prospective observational study done at the department of gastroenterology and hepatology, Apollo Hospitals, Chennai from April 2011 to March 2013. All patients who fulfilled the inclusion criteria underwent detailed history taking, physical examination and relevant laboratory investigations. One hundred patients were selected for the scope of the study.
Results: Sixty-eight per cent of patients were in the age group of 45 to 65 years. The mean age ± SD of the study subjects was 51.2 ± 9.7 years. The mean age for male patients was 50.5 ± 10.1 years, and for females was 54 ± 7.3 years. Cirrhosis was due to alcohol in 36% of the patients, viral hepatitis in 28% (HBV in 10% and HCV in 18%) patients. 42% were in Child’s class B, and the remaining 58% were in Child’s class C. MELD score was less than 20 in 62% patients. One third was diabetic; one third gave the history of backache. History of smoking was present in one fifth (20%) patients, and a history of fracture (most of them were traumatic) was present in 13% of patients. By using Hologic DXA database at the lumbar spine, osteopenia and osteoporosis were diagnosed in 44% and 38 % patients respectively.
At the femoral neck, osteopenia and osteoporosis were diagnosed in 45% and 9% of patients. By using ICMR database at the lumbar spine, osteopenia and osteoporosis were diagnosed in 38% and 17% patients respectively. Similarly, at the femoral neck, osteopenia and osteoporosis were diagnosed in 34% and 5%. By using the Hologic DXA database, osteopenia and osteoporosis were diagnosed in 42% and 40 % patients. By using ICMR database, osteopenia and osteoporosis were diagnosed in 43% and 19% patients respectively.
Conclusion: In light of the above results, the present study revealed a high prevalence of low bone mineral density (osteopenia and osteoporosis) in Indian patients with cirrhosis of liver awaiting liver transplantation. The lumbar spine was the most frequently and severely affected site in hepatic osteodystrophy.
Keywords: Osteopenia, Osteoporosis, Low Bone Mineral Density, Liver Cirrhosis
TWO DIFFERENT CASES OF NEW ONSET NEUROPATHY AFTER PANCREATIC TRANSPLANTATION
Authors: Nagarathinam Vedhanayagam , Dhanaraj  , Nikhil  , Vaidya Anil 
Published: April 2021

Presenting two different cases of new onset peripheral neuropathy after pancreatic transplantation. One demyelinating in type which is rare in literature ,recovered spontaneously and other one is axonal in type improved with early aggressive intra-venous immunoglobulin therapy.
Keywords: Tacrolimus, Post transplant, IV-IG(Intravenous immunoglobulin), Demyelinating and Axonal neuropathy
RELATION OF GRADES OF HYPONATREMIA ON SEVERITY OF BRONCHIOLITIS
Authors: Ninan Nirmal Georgie , TM Sanjeev Kumar 
Published: April 2021

Background and objectives: Hyponatremia often occurs among children with bronchiolitis. It is the most common electrolyte abnormality associated with severe disease course. Aim was to study relation between sodium levels and severity of bronchiolitis
Methodology: Cross-sectional study was conducted on 72 infants admitted with bronchiolitis to Pediatrics ward/ICU, JMMC. Infants with recurrent respiratory or super added bacterial infections, born <34weeks gestation, any chronic disorder or medications that can influence electrolyte levels or parents unwilling for consent were excluded. Severity of bronchiolitis was scored and classified into mild, moderate, severe. Sodium levels were determined and grouped (in mmol/L) into normonatremia (135-145) and hyponatremia (mild (130-134), moderate (125-129) and severe (≤124). The grade of hyponatremia with severity of bronchiolitis was compared. Chi square test was used to test the association of severity of bronchiolitis and category of hyponatremia. ANOVA test was done to compare the severity of bronchiolitis with sodium levels.
Results: Hyponatremia was seen in 50% of cases admitted with severe bronchiolitis, which when compared to mild and moderate bronchiolitis, was statistically significant (p<0.001). ANOVA showed mean sodium levels of mild, moderate and severe bronchiolitis were 138.44±1.81, 137.37±1.76 and 135.43±3.93 respectively; these were statistically significant (p<0.001). A pairwise comparison between mild and moderate bronchiolitis with hyponatremia was not found to be statistically significant (p-0.769) but comparison between mild and severe bronchiolitis with hyponatremia was statistically significant (p<0.001)
Conclusion: There is statistically significant relation between hyponatremia and severity of bronchiolitis. Hyponatremia could be considered as a marker to assess the severity of bronchiolitis.
Keywords: Bronchiolitis, Hyponatremia, Respiratory distress
RELATIONSHIP OF ALCOHOL AND TOBACCO WITH AVN OF FEMORAL HEAD IN ADULT INDIAN POPULATION
Authors: Suman Himanshu , Sharma Yash , Acharya Puneet Kumar , Krishna Jyoti , Patidar Nilesh Kumar 
Published: April 2021

Background: Avascular necrosis (AVN) or osteonecrosis is the death of bone tissues due to decreased blood flow of femoral head, it is a major orthopaedic disease with many risk factors including the chronic alcohol and tobacco consumption.
Aims and objectives: To study the relationship of alcohol and tobacco with AVN of femoral head in adult population.
Materials and Methods: This study included 72 patients of AVN of femoral head (ONFH) who attending our hospital between Sept 2018 to Sept 2020. History of alcoholism and tobacco consumption, detailed information of the amount and duration of smoking and alcohol intake was recorded.
Results: Majority of the AVN patients were working age groups males (72%) and 28% were females. Out of 72 patient 55% had history of alcohol consumption and 60% were smokers which indicates a positive correlation of cellular toxicity with AVN of femoral head.
Conclusion: Present study conclude that the alcohol ingestion and tobacco smoking are the major cause of cellular toxicity and AVN of femoral heads.
Keywords: alcohol drinking, femur head necrosis, smoking
Investigation of the Effect of 60% of the Addition of Latex on Asphalt Pen 60-70
Authors: Barus Diana Alemin 
Published: April 2021

This study discussed the increase of latex 60% addition to obtain the standard of asphalt 60-70. The comparison used were without the increase of latex addition (L0), 1000 g penetration of asphalt 60-70 with 100 g latex with 60 % degree or 10 phr ( L1), 1000 g penetration of asphalt 60-70 with 200 g latex 60 % degree or 20 phr ( L2), 1000 g penetration of asphalt 60-70 with 300 g latex 60 % degree or 30 phr ( L3), 1000 g penetration of asphalt 60-70 with 400 g latex 60 % degree or 40 phr ( L4). All of the samples homogenized by heating at 150ºC temperature and 250 rpm within 30 minutes then soaked in the tub for 30 minutes at 25ºC.
DIGITAL SOCIALIZATION, TAG THINKING AND THE MODERN EDUCATIONAL PROCESS IN THE STATE LEGAL DIMENSION OF RUSSIA
Authors: ПОПОВА Анна Владиславовна 
Published: April 2021

The development of digital technologies at the end of the 20th century has led to the emergence of a new generation of human civilization – Generation Z. The members of the former possess a number of peculiarities that influence the development of a learner’s personal potential. The COVID-19 pandemic has led to a rapid transition towards distance learning, the widespread use of digital education and the spread of artificial intelligence technologies. The task of the teaching staff is to level the negative features of new generations of students and, above all, clip (tag) thinking. Purpose: based on the analysis of the cognitive abilities of the Generation Z, the author proposes didactics and methodology of the interactive system of legal education that can take into account students’ analytical abilities associated with the development of clip thinking. Methods: the author uses empirical methods of comparison, description, interpretation as well as theoretical methods of formal and dialectical logic. Special scientific methods such as comparative-legal and legal-dogmatic are used. Results: on the basis of a comparative legal analysis of scientific literature, the author defines the concept and features of a new educational virtual communication system for legal education with a view to forming a worthy member of civil society at the current stage of the development of the rule-of-law state in Russia.
Kepemilikan Tanah Adat Suatu Kajian Pada Masyarakat Hukum Adat Tidore (Studi Kasus di Kelurahan Folarora, Kecamatan Tidore, Kota Tidore Kepulauan)
Authors: Arlina Nurizka 
Published: April 2021

Territorial unity (land) as one of the elements froming a customary law community, is one of the important elements related to certain regulations in terms of ownership, control and management as well as the process of transfering. This often creates problems, such as what happened on Tidore Island as the central area of the Tidore Sultanate. Hale Gimalaha, which was the land given by the holder of GimalahaTomayouin the Government Structure of Tidore Sultanate, turned out to be a certificate of ownership by one of the GimalahaTomayou. The status of customary land which is converted into ownership rights will be the mainfocus of this research. The method used is socio-legal research using primary data through in-depth interviews with competent parties and the community in Folarora Village, Tidore District, Tidore Islands City, as well as historical and sociological descriptions. So it can be concluded that the main obstacle if problems arise with regard to customary land lies in evidence. Customary land ownership in the Tidore customary law community generally doesn’t have a written (formal) proof of ownership. Communities in obtaining ownership rights over customary land in accordance with applicable customary rules and based on information from simo-simo. The problem with the Hale Gimalaha, thatGimalahaTomayoumade a certificate of ownership, so there is an alternative solution through the Imperial Court Institution or internal root by GimalahaTomayou. These problems lasted for a long time and occurred among the generations of GimalahaTomayou, eventually reluctance to resolve the conflict because people believed a magical imbalance would arise when the problems that had first returned to the surface.
Cinética de degradação do ácido ascórbico do mesocarpo do maracujá pré-tratado osmoticamente e o estudo da sua estabilidade
Authors: Andrade Fabrícia Santos , Melo Bruno Henrique da Silva , Galdino Pablícia Oliveira , Santiago Ângela Maria , Galdino Plúvia Oliveira , Muniz Cecília Elisa de Sousa , Almeida Raphael Lucas Jacinto , Almeida Marcello Maia de , Santos Newton Carlos , Luna Israel Alves 
Published: April 2021

A presente pesquisa tem como objetivo avaliar o efeito da temperatura na degradação do ácido ascórbico do mesocarpo de maracujá pré-tratado osmoticamente e o estudo da sua estabilidade no decorrer do armazenamento. As fatias do mesocarpo do maracujá foram desidratadas osmoconvectivamente (60 °Brix/60 °C), em seguida submetidas a secagem convectiva nas temperaturas de 50, 60 e 70 °C até massa constante. No decorrer do processo de secagem foram realizadas uma cinética de degradação do ácido áscorbico e aos dados experimentais foram ajustados modelos cinéticos de zero e primeira ordem, além de se calcular o tempo de meia vida, a energia de ativação e o coeficiente de reação (Q10). As fatias in natura, osmodesidratadas e no decorrer de 90 dias de armazenamento, foram submetidas as caracterizações físico-químicas. A desidratação osmoconvectiva promoveu uma maior incorporação de sólidos solúveis totais (19 °Brix) e menor percentual de água (58,51%) as fatias do mesocarpo de maracujá. O processo de secagem promoveu redução no teor de ácido ascórbico, no entanto, este composto foi mais preservado na temperatura de 60 ºC. O modelo cinético de primeira ordem, mostrou-se mais adequado para representar a cinética de degradação do ácido ascórbico, no qual apresentou uma energia de ativação de 83,33 kJ.mol-1. Durante 90 dias de armazenamento, as amostras obtiveram uma redução de 57,43% de ácido ascórbico, ficando ainda com o teor considerável, o teor de água na ordem de 10,77% e o pH abaixo de 4,5 impossibilitando o crescimento microbiano, consequentemente aumentando a vida de prateleira.
Tuberosas amiláceas no Estado de São Paulo: Canais de comercialização e importância econômica
Authors: Guedes Politon Thiago Pereira , Cândido Hebert Teixeira , Fernandes Adalton Mazetti , Souza Alana Pontes Sun de 
Published: April 2021

O objetivo da pesquisa foi avaliar a importância econômica das hortaliças tuberosas amiláceas para o estado de São Paulo. Essas hortaliças são capazes de acumular amido como material de reserva, esse que é a principal fonte de energia para a alimentação humana. Dessa forma, para essa análise foi realizado um levantamento de informações nos bancos de dados de instituições de pesquisa e empresas governamentais. Buscaram-se valores de produção, comercialização e os principais canais utilizados para o escoamento desses produtos, contextualizando-os com a importância social que representam para alguns municípios. Os canais de comercialização estudados foram os entrepostos, as compras governamentais e a exportação. Percebeu-se que os entrepostos são de grande importância para o escoamento dos produtos in natura e que as compras governamentais, além de impulsionar a agricultura familiar, contribuem para a possibilidade de agregar valor aos produtos, possibilitando a comercialização de produtos processados e a diversificação da produção, a qual, por vezes, contribui com a alimentação da família. Verificou-se que essas hortaliças são de grande importância social para os municípios de Tapiraí e Piedade, visto que são os principais fornecedores para os entrepostos paulistas e a agricultura é responsável por mais da metade da ocupação laboral da população. O comércio exterior, também se apresenta como uma importante via para comercialização, não só pelo volume de produtos escoados, mas também pelo maior valor agregado. Há ainda, aqueles produtos que não possuem uma cadeia produtiva estruturada, mas que são de grande importância para algumas comunidades tradicionais, exemplo, araruta, mangarito e taioba.
Potential Fluid Biomarkers and a Prediction Model for Better Recognition Between Multiple System Atrophy-Cerebellar Type and Spinocerebellar Ataxia
Authors: Guo Shuo , Zhao Bi , An Yunfei , Zhang Yu , Meng Zirui , Zhou Yanbing , Zheng Mingxue , Yang Dan , Wang Minjin , Ying Binwu 
Published: April 2021

ObjectiveThis study screened potential fluid biomarkers and developed a prediction model based on the easily obtained information at initial inspection to identify ataxia patients more likely to have multiple system atrophy-cerebellar type (MSA-C).MethodsWe established a retrospective cohort with 125 ataxia patients from southwest China between April 2018 and June 2020. Demographic and laboratory variables obtained at the time of hospital admission were screened using Least Absolute Shrinkage and Selection Operator (LASSO) regression and logistic regression to construct a diagnosis score. The receiver operating characteristic (ROC) and decision curve analyses were performed to assess the accuracy and net benefit of the model. Also, independent validation using 25 additional ataxia patients was carried out to verify the model efficiency. Then the model was translated into a visual and operable web application using the R studio and Shiny package.ResultsFrom 47 indicators, five variables were selected and integrated into the prediction model, including the age of onset (AO), direct bilirubin (DBIL), aspartate aminotransferase (AST), eGFR, and synuclein-alpha. The prediction model exhibited an area under the curve (AUC) of 0.929 for the training cohort and an AUC of 0.917 for the testing cohort. The decision curve analysis (DCA) plot displayed a good net benefit for this model, and external validation confirmed its reliability. The model also was translated into a web application that is freely available to the public.ConclusionThe prediction model that was developed based on laboratory and demographic variables obtained from ataxia patients at admission to the hospital might help improve the ability to differentiate MSA-C from spinocerebellar ataxia clinically.
Timing and Spectrum of Neurological Complications After Flow Diverter Implantation for Intracranial Aneurysms
Authors: Charbonnier Guillaume , Desilles Jean-Philippe , Escalard Simon , Maier Benjamin , Ciccio Gabriele , Smajda Stanislas , Fahed Robert , Delvoye François , Redjem Hocine , Blanc Raphaël , Piotin Michel , Mazighi Mikael 
Published: April 2021

Background and Purpose: The aim of this study was to characterize neurological complications after flow diverter (FD) treatment on a long follow-up cohort and identify predictive factors associated with these complications.Methods: This study was conducted on a monocentric cohort of patients treated for intracranial aneurysms by FD.Results: Between September 2008 and July 2018, 413 patients were treated for 514 aneurysms: 18% of the patients presented with at least one neurological complication during a median follow-up of 446 days (IQR 186–1,210). Sixty-one patients presented with ischemic complications, 13 with hemorrhagic ones and 10 with compressive processes. Among 89 neurological complications 64.5% were peri-operative (occurring within the 30 days following the procedure) and 35.5% were delayed after 1 month.Conclusions: Overall, neurological complications after FD implantation were overrepresented by cerebrovascular ischemic events occurring during the peri-operative period, but also in a delayed manner after 1 year. Long-term follow-up is relevant after aneurysm intervention using FD.
A Modified in vitro Clot Lysis Assay Predicts Outcomes in Non-traumatic Intracerebral Hemorrhage Stroke Patients—The IRONHEART Study
Authors: Orbán-Kálmándi Rita , Árokszállási Tamás , Fekete István , Fekete Klára , Héja Máté , Tóth Judit , Sarkady Ferenc , Csiba László , Bagoly Zsuzsa 
Published: April 2021

Background: Non-traumatic intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes and results in a higher rate of mortality as compared to ischemic strokes. In the IRONHEART study, we aimed to find out whether a modified in vitro clot lysis assay method, that includes the effect of neutrophil extracellular traps (NETs) might predict ICH outcomes.Patients and Methods: In this prospective, observational study, 89 consecutive non-traumatic ICH patients were enrolled. Exclusion criteria included aneurysm rupture, cancer, liver- or kidney failure or hemorrhagic diathesis. On admission, detailed clinical and laboratory investigations were performed. ICH volume was estimated based on CT performed on admission, day 14 and 90. A conventional in vitro clot lysis assay (CLA) and a modified CLA (mCLA) including cell-free-DNA and histones were performed from stored platelet-free plasma taken on admission. Clot formation and lysis in case of both assays were defined using the following variables calculated from the turbidimetric curves: maximum absorbance, time to maximum absorbance, clot lysis times (CLT) and area under the curve (CLA AUC). Long-term ICH outcomes were defined 90 days post-event by the modified Rankin Scale (mRS). All patients or relatives provided written informed consent.Results: Patients with more severe stroke (NIHSS&gt;10) presented significantly shorter clot lysis times of the mCLA in the presence of DNA and histone as compared to patients with milder stroke [10%CLT: NIHSS 0–10: median 31.5 (IQR: 21.0–40.0) min vs. NIHSS&gt;10: 24 (18–31.0) min, p = 0.032]. Shorter clot lysis times of the mCLA showed significant association with non-survival by day 14 and with unfavorable long-term outcomes [mRS 0–1: 36.0 (22.5.0–51.0) min; mRS 2–5: 23.5 (18.0–36.0) min and mRS 6: 22.5 (18.0–30.5) min, p = 0.027]. Estimated ICH volume showed significant negative correlation with mCLA parameters, including 10%CLT (r = −0.3050, p = 0.009). ROC analysis proved good diagnostic performance of mCLA for predicting poor long-term outcomes [AUC: 0.73 (0.57–0.89)]. In a Kaplan-Meier survival analysis, those patients who presented with an mCLA 10%CLT result of &gt;38.5 min on admission showed significantly better survival as compared to those with shorter clot lysis results (p=0.010).Conclusion: Parameters of mCLA correlate with ICH bleeding volume and might be useful to predict ICH outcomes.
A Novel Homozygous VPS13B Splice-Site Mutation Causing the Skipping of Exon 38 in a Chinese Family With Cohen Syndrome
Authors: Li Liangshan , Bu Xiangmao , Ji Yuhua , Tan Ping , Liu Shiguo 
Published: April 2021

Background: Cohen syndrome (CS) is a clinically heterogeneous disorder characterized by extensive phenotypic variation with autosomal recessive inheritance. VPS13B was identified to be the disease-causing gene for CS. The objectives of the present study were to screen likely pathogenic mutations of the patient with developmental delay and mental retardation, and to determinate the effect of this splice-site mutation by reverse transcription analysis.Methods: Whole exome sequencing (WES) in combination with Sanger sequencing were performed to identify the causative mutations of this CS family. Subsequently, the impact of the intronic variant on splicing was analyzed by reverse transcription and the construction of expression vector.Results: A novel homozygous splice-site mutation (c.6940+1G&gt;T) in the VPS13B gene was identified in this proband. Sanger sequencing analysis of the cDNA demonstrated that the c.6940+1G&gt;T variant could cause the skipping of entire exon 38, resulting in the loss of 208 nucleotides and further give rise to the generation of a premature in-frame stop codon at code 2,247.Conclusions: The homozygous VPS13B splicing variant c.6940+1G&gt;T was co-segregated with the CS phenotypes in this family and was identified to be the cause of CS after comprehensive consideration of the clinical manifestations, genetic analysis and cDNA sequencing result.