bluuebunny/crossref_metadata_2025_split huggingface dataset:
A questionnaire to measure the quality of midwifery care in the postpartum period from women’s point of view: development and psychometric testing of MMAYpostpartum
Authors: Peters Mirjam , Kolip Petra , Schäfers Rainhild 
Published: June 2021

Abstract
Background
Home postpartum care is a major part of midwifery care in Germany. The user perspective plays an increasingly important role in the evaluation of health services, but there is a lack of valid and theoretically based measuring instruments, especially in midwifery care. The aim of this study was to develop and validate an instrument for measuring quality of midwifery care in the postpartum period from the perspective of women.

Methods
The following steps were taken to achieve this: (1) definition of the goals of midwifery work; (2) literature-based item development; (3) item selection based on a pre-test (n = 16); (4) item reduction and investigation of factor structure by means of explorative factor analysis (EFA; n = 133);(5) second EFA (n = 741) and confirmatory factor analysis (CFA; n = 744) based on a split representative sample survey; (6) hypothesis-based testing of correlations to sociodemographic characteristics of women and to characteristics of care.

Results
Measurement of Midwifery quality postpartum (MMAYpostpartum) consists of three scales with a total of 17 items which were found to have acceptable internal consistency: Personal Control (Cronbach’s alpha = .80), Trusting Relationship (Cronbach’s alpha = .87) and Orientation and Security (Cronbach’s alpha = .78). CFA verified and confirmed three factors: CFI = .928, TLI = .914, RMSEA = 0.073.

Conclusion
MMAYpostpartum is a predominantly valid, reliable short tool for evaluating the quality of midwifery care postpartum. It can be used to evaluate midwifery care, to compare different care models and in intervention research. It thus supports the orientation of midwives’ work towards the needs of women and their families.
UGT1A1 mutation association with increased bilirubin levels and severity of unconjugated hyperbilirubinemia in ABO incompatible newborns of China
Authors: Yang Hui , Lin Fen , Chen Zi-kai , Zhang Lin , Xu Jia-Xin , Wu Yong-Hao , Gu Jing-Ying , Ma Yu-Bin , Li Jian-Dong , Yang Li-Ye 
Published: June 2021

AbstractBackgroundNeonatal hyperbilirubinemia causing jaundice is common in East Asian population. Uridine diphosphate glucuronosyltransferase isoenzyme (UGT1A1) glucuronidates bilirubin and converts the toxic form of bilirubin to its nontoxic form.MethodA retrospective study was conducted to review clinical information of ABO hemolysis neonates (ABO HDN) admitted to the Department of Neonatology, referred for neonatal hyperbilirubinemia, in a large general hospital of southern China from 2011 to 2017. Variation status of UGT1A1 was determined by direct sequencing or genotype assays.ResultSixty-nine ABO HDNs were included into the final analysis. UGT1A1 c.211 G > A mutation (UGT1A1*6, p.Arg71Gly, rs4148323) was significantly associated with the increased bilirubin level in ABO HDNs, after adjusted by age, sex and feeding method (P = 0.019 for TBIL,P = 0.02 for IBIL). Moreover, heterozygous and/or homozygous UGT1A1 mutations in the coding sequence region were significantly associated with the increased risk of developing hazardous hyperbilirubinemia (as defined by TSB > 427 umol/L) as compared those with a normal UGT1A1 genotype (ORadj = 9.16, 95%CI 1.99–42.08,P = 0.002) in the study cohort.ConclusionUGT1A1 variant in coding region is actively involved in the pathogenesis of ABO hemolysis related neonatal hyperbilirubinemia. Genetic assessment of UGT1A1 may be useful for clinical diagnosis of neonatal unconjugated hyperbilirubinemia.
Altered spontaneous neural activity in the precuneus, middle and superior frontal gyri, and hippocampus in college students with subclinical depression
Authors: Zhang Bo , Qi Shouliang , Liu Shuang , Liu Xiaoya , Wei Xinhua , Ming Dong 
Published: June 2021

Abstract
Background
Subclinical depression (ScD) is a prevalent condition associated with relatively mild depressive states, and it poses a high risk of developing into major depressive disorder (MDD). However, the neural pathology of ScD is still largely unknown. Identifying the spontaneous neural activity involved in ScD may help clarify risk factors for MDD and explore treatment strategies for mild stages of depression.

Methods
A total of 34 ScD subjects and 40 age-, sex-, and education-matched healthy controls were screened from 1105 college students. The amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) of resting-state fMRI were calculated to reveal neural activity. Strict statistical strategies, including Gaussian random field (GRF), false discovery rate (FDR), and permutation test (PT) with threshold-free cluster enhancement (TFCE), were conducted. Based on the altered ALFF and ReHo, resting-state functional connectivity (RSFC) was further analyzed using a seed-based approach.

Results
The right precuneus and left middle frontal gyrus (MFG) both showed significantly increased ALFF and ReHo in ScD subjects. Moreover, the left hippocampus and superior frontal gyrus (SFG) showed decreased ALFF and increased ReHo, respectively. In addition, ScD subjects showed increased RSFC between MFG and hippocampus compared to healthy controls, and significant positive correlation was found between the Beck Depression Inventory-II (BDI-II) score and RSFC from MFG to hippocampus in ScD group.

Conclusion
Spontaneous neural activities in the right precuneus, left MFG, SFG, and hippocampus were altered in ScD subjects. Functional alterations in these dorsolateral prefrontal cortex and default mode network regions are largely related to abnormal emotional processing in ScD, and indicate strong associations with brain impairments in MDD, which provide insight into potential pathophysiology mechanisms of subclinical depression.
Shared clinical decision-making experiences in nursing: a qualitative study
Authors: Chung Fen-Fang , Wang Pao-Yu , Lin Shu-Chuan , Lee Yu-Hsia , Wu Hon-Yen , Lin Mei-Hsiang 
Published: June 2021

Abstract
Background
Shared decision making (SDM) is a patient-centered nursing concept that emphasizes the autonomy of patients. SDM is a co-operative process that involves information exchange and communication between medical staff and patients for making treatment decisions. In this study, we explored the experiences of clinical nursing staff participating in SDM.

Methods
This study adopted a qualitative research design. Semistructured interviews were conducted with 21 nurses at a medical center in northern Taiwan. All interview recordings were transcribed verbatim. Content analysis was performed to analyze the data.

Results
The findings yielded the following three themes covering seven categories: knowledge regarding SDM, trigger discussion and coordination, and respect of sociocultural factors.

Conclusions
The results of this study describe the experiences of clinical nursing staff participating in SDM and can be used as a reference for nursing education and nursing administrative supervisors wishing to plan and enhance professional nursing SDM in nursing education.
Costs and healthcare utilisation of patients with chronic kidney disease in Spain
Authors: Escobar Carlos , Palacios Beatriz , Aranda Unai , Capel Margarita , Sicras Antoni , Sicras Aram , Hormigo Antonio , Alcázar Roberto , Manito Nicolás , Botana Manuel 
Published: June 2021

Abstract
Background
Data about the impact of chronic kidney disease (CKD) on health care costs in Spain are scarce This study was aimed to evaluate cumulative costs and healthcare utilisation in CKD in Spain.

Methods
Observational, retrospective, population-based study, which included adults who received care for CKD between 2015 and 2019. Healthcare and medication costs were summarized on a yearly basis starting from the index date (1st January 2015), and then cumulatively until 2019.

Results
We identified 44,214 patients with CKD (year 2015: age 76.4 ± 14.3 years, 49.0% women, albumin-to-creatinine ratio 362.9 ± 176.8 mg/g, estimated glomerular filtration rate 48.7 ± 13.2 mL/min/1.73 m2). During the 2015–2019 period, cumulative CKD associated costs reached 14,728.4 Euros, being cardiovascular disease hospitalizations, particularly due to heart failure and CKD, responsible for 77.1% of costs. Total medication cost accounted for 6.6% of the total cost. There was a progressive decrease in cardiovascular disease hospital costs per year (from 2741.1 Euros in 2015 to 1.971.7 Euros in 2019). This also occurred with cardiovascular and diabetic medication costs, as well as with the proportion of hospitalizations and mortality. Costs and healthcare resources use were higher in the DAPA-CKD like population, but also decreased over time.

Conclusions
Between 2015 and 2019, costs of patients with CKD in Spain were high, with cardiovascular hospitalizations as the key determinant. Medication costs were responsible for only a small proportion of total CKD costs. Improving CKD management, particularly with the use of cardiovascular and renal protective medications may be helpful to reduce CKD burden.
Liquid biopsy for therapy monitoring in early-stage non-small cell lung cancer
Authors: Nagasaka Misako , Uddin Mohammed Hafiz , Al-Hallak Mohammed Najeeb , Rahman Sarah , Balasubramanian Suresh , Sukari Ammar , Azmi Asfar S. 
Published: June 2021

AbstractLiquid biopsy is now considered a valuable diagnostic tool for advanced metastatic non-small cell lung cancer (NSCLC). In NSCLC, circulating tumor DNA (ctDNA) analysis has been shown to increase the chances of identifying the presence of targetable mutations and has been adopted by many clinicians owing to its low risk. Serial monitoring of ctDNA may also help assess the treatment response or for monitoring relapse. As the presence of detectable plasma ctDNA post-surgery likely indicates residual tumor burden, studies have been performed to quantify plasma ctDNA to assess minimal residual disease (MRD) in early-stage resected NSCLC. Most data on utilizing liquid biopsy for monitoring MRD in early-stage NSCLC are from small-scale studies using ctDNA. Here, we review the recent research on liquid biopsy in NSCLC, not limited to ctDNA, and focus on novel methods such as micro RNAs (miRNA) and long non-coding (lncRNA).
Serum TNFα levels at 24 h after certolizumab pegol predict effectiveness at week 12 in patients with rheumatoid arthritis from TSUBAME study
Authors: Miyazaki Yusuke , Nakano Kazuhisa , Nakayamada Shingo , Kubo Satoshi , Iwata Shigeru , Hanami Kentaro , Fukuyo Shunsuke , Miyagawa Ippei , Yamaguchi Ayako , Kawabe Akio , Saito Kazuyoshi , Tanaka Yoshiya 
Published: June 2021

AbstractObjectiveTo estimate the relationship between serum TNFα, IL-6, and serum CZP levels and the clinical response to CZP in RA patients in the TSUBAME study.MethodsOne hundred patients with RA who received CZP were enrolled and multiple clinical parameters, serum TNFα, IL-6, and CZP levels, were assessed at 0, 24, and 48 h and 12 weeks after first administration of CZP.ResultsThe CZP therapy significantly improved the DAS28(ESR) at 12 weeks. Serum TNFα and IL-6 levels significantly decreased from baseline at 24 h after the first administration of CZP. Serum TNFα levels at baseline were not related to clinical parameters at baseline and improvement in DAS28(ESR) at week 12 of the CZP therapy. However, serum levels of CZP at 24 h were strongly and negatively correlated with TNFα levels at 24 h, which were negatively correlated with improved rate in DAS28(ESR) at week 12. Only serum levels of TNFα, but not IL-6, at 24 h had a negative correlation with achievement of DAS28(ESR)<2.6 at week 12 by the multivariate analysis (odds ratio 0.01, 95% confidence interval 0.04e−2–0.22,p< 0.01). A receiver operating characteristic analysis was conducted to estimate the achievement of DAS28(ESR)<2.6 at week 12 after the CZP therapy and cut-off value of 0.76 pg/ml for serum levels of TNFα at 24 h was yielded (area under the curve=0.75). DAS28(ESR)<2.6 was achieved at week 12 significantly more patients with lower serum TNF levels (≦0.76 pg/ml) at 24 h than those with higher TNF levels.ConclusionsCZP was highly effective in RA patients who had low serum TNFα levels at 24 h after the initial administration of CZP. Therefore, we propose that serum TNFα levels at 24 h could serve as a biomarker predicting effectiveness to CZP at week 12 in patients with RA.Trial registrationClinical trial registration number:UMIN ID:000022831
Using social media for sub-event detection during disasters
Authors: Belcastro Loris , Marozzo Fabrizio , Talia Domenico , Trunfio Paolo , Branda Francesco , Palpanas Themis , Imran Muhammad 
Published: June 2021

AbstractSocial media platforms have become fundamental tools for sharing information during natural disasters or catastrophic events. This paper presents SEDOM-DD (Sub-Events Detection on sOcial Media During Disasters), a new method that analyzes user posts to discover sub-events that occurred after a disaster (e.g., collapsed buildings, broken gas pipes, floods). SEDOM-DD has been evaluated with datasets of different sizes that contain real posts from social media related to different natural disasters (e.g., earthquakes, floods and hurricanes). Starting from such data, we generated synthetic datasets with different features, such as different percentages of relevant posts and/or geotagged posts. Experiments performed on both real and synthetic datasets showed that SEDOM-DD is able to identify sub-events with high accuracy. For example, with a percentage of relevant posts of 80% and geotagged posts of 15%, our method detects the sub-events and their areas with an accuracy of 85%, revealing the high accuracy and effectiveness of the proposed approach.
Acute-onset paraplegia as an unexpected complication under general anesthesia in supine position during abdominal endovascular aneurysm repair: a case report
Authors: Morio Atsushi , Miyoshi Hirotsugu , Saeki Noboru , Toyota Yukari , Tsutsumi Yasuo M. 
Published: June 2021

Abstract
Background
Acute onset paraplegia after endovascular aneurysm repair (EVAR) is a rare but well-known complication. We here show a 79-year-old woman with paraplegia caused by static and dynamic spinal cord insult not by ischemia after EVAR.

Case presentation
The patient underwent EVAR for abdominal aortic aneurism under general anesthesia in the supine position. She had a medical history of lumbar canal stenosis. After the surgery, we recognized severe paraplegia and sensory disorder of lower limbs. Although the possibility of spinal cord ischemia was considered at that time, postoperative magnetic resonance imaging (MRI) revealed burst fracture of vertebra and compressed spinal cord.

Conclusions
Patients with spinal canal stenosis can cause extrinsic spinal cord injury even with weak external forces. Thus, even after EVAR, it is important to consider extrinsic factors as the cause of paraplegia.
Evaluating implementation of the Transparency and Openness Promotion (TOP) guidelines: the TRUST process for rating journal policies, procedures, and practices
Authors: Mayo-Wilson Evan , Grant Sean , Supplee Lauren , Kianersi Sina , Amin Afsah , DeHaven Alex , Mellor David 
Published: June 2021

Abstract
Background
The Transparency and Openness Promotion (TOP) Guidelines describe modular standards that journals can adopt to promote open science. The TOP Factor is a metric to describe the extent to which journals have adopted the TOP Guidelines in their policies. Systematic methods and rating instruments are needed to calculate the TOP Factor. Moreover, implementation of these open science policies depends on journal procedures and practices, for which TOP provides no standards or rating instruments.

Methods
We describe a process for assessing journal policies, procedures, and practices according to the TOP Guidelines. We developed this process as part of the Transparency of Research Underpinning Social Intervention Tiers (TRUST) Initiative to advance open science in the social intervention research ecosystem. We also provide new instruments for rating journal instructions to authors (policies), manuscript submission systems (procedures), and published articles (practices) according to standards in the TOP Guidelines. In addition, we describe how to determine the TOP Factor score for a journal, calculate reliability of journal ratings, and assess coherence among a journal’s policies, procedures, and practices. As a demonstration of this process, we describe a protocol for studying approximately 345 influential journals that have published research used to inform evidence-based policy.

Discussion
The TRUST Process includes systematic methods and rating instruments for assessing and facilitating implementation of the TOP Guidelines by journals across disciplines. Our study of journals publishing influential social intervention research will provide a comprehensive account of whether these journals have policies, procedures, and practices that are consistent with standards for open science and thereby facilitate the publication of trustworthy findings to inform evidence-based policy. Through this demonstration, we expect to identify ways to refine the TOP Guidelines and the TOP Factor. Refinements could include: improving templates for adoption in journal instructions to authors, manuscript submission systems, and published articles; revising explanatory guidance intended to enhance the use, understanding, and dissemination of the TOP Guidelines; and clarifying the distinctions among different levels of implementation.
Research materials are available on the Open Science Framework: https://osf.io/txyr3/.
Impact of metal oxide nanoparticles on cotton (Gossypium hirsutum L.): a physiological perspective
Authors: SINGH BRAR Ravinderdeep , KUMAR Avneesh , KAUR Simranjeet , SAHA Sandip , KUMAR Anuj , KUMAR Sandeep 
Published: June 2021

AbstractCotton production substantiated a crucial part in the escalating economic development of many countries. To realize the increasing global demand for cotton, the emphasis should be laid on to improve cotton fiber growth and production. The bioengineered transgenic cotton proved expedient in resolving inadequacies of conventional cotton, but still required improvements to encounter heightened demand of textile industries. One possible solution pertaining to this has been provided by nanoscience in the form of metal or metal oxide nanoparticles. These metal oxide nanoparticles have easy access to the various parts of cotton plants through its transportation system, and thus significantly influence several parameters relative to the growth and production of cotton fiber. This review summarizes the distribution and accumulation of metal oxide nanoparticles in cotton plant and its impact on different plant growth-promoting factors, which resulted in the improved cotton yields.Graphical abstractMetal/metal-oxide nanoparticles have easy access to the various parts of cotton plant through its transportation system, and thus significantly influence its growth parameters, and hence the production of cotton fiber. This review summarizes the distribution and accumulation of metal oxide nanoparticles in cotton plants, and its impact on different plant growth promoting factors.
A secure and highly efficient first-order masking scheme for AES linear operations
Authors: Ming Jingdian , Zhou Yongbin , Li Huizhong , Zhang Qian 
Published: June 2021

AbstractDue to its provable security and remarkable device-independence, masking has been widely accepted as a noteworthy algorithmic-level countermeasure against side-channel attacks. However, relatively high cost of masking severely limits its applicability. Considering the high tackling complexity of non-linear operations, most masked AES implementations focus on the security and cost reduction of masked S-boxes. In this paper, we focus on linear operations, which seems to be underestimated, on the contrary. Specifically, we discover some security flaws and redundant processes in popular first-order masked AES linear operations, and pinpoint the underlying root causes. Then we propose a provably secure and highly efficient masking scheme for AES linear operations. In order to show its practical implications, we replace the linear operations of state-of-the-art first-order AES masking schemes with our proposal, while keeping their original non-linear operations unchanged. We implement four newly combined masking schemes on an Intel Core i7-4790 CPU, and the results show they are roughly 20% faster than those original ones. Then we select one masked implementation named RSMv2 due to its popularity, and investigate its security and efficiency on an AVR ATMega163 processor and four different FPGA devices. The results show that no exploitable first-order side-channel leakages are detected. Moreover, compared with original masked AES implementations, our combined approach is nearly 25% faster on the AVR processor, and at least 70% more efficient on four FPGA devices.
Purification and modification of neem gum for enhancement of its suspending property
Authors: Kalaskar Mohan G. , Mutha Rakesh E. , Tatiya Anilkumar U. , Firke Sandip D. , Surana Sanjay J. , Dhoka Komal A. , Heda Komal 
Published: June 2021

Abstract
Background
The present study aimed to purify and modify the neem gum (NG) to evaluate its dispersing ability in a pharmaceutical suspension formulation. The modification was carried out to cross-link the sugars as carbamate in the presence of calcium chloride to improve the suspending property. Physiochemical properties such as pH, solubility, swelling index and ash value were performed before investigating the dispersing potential. The suspending potential of neem gum was studied in its different forms such as purified and modified gum in paracetamol suspension and was compared with sodium carboxymethylcellulose (CMC) being used as standard at a concentration range of 0.25–1% (w/v). The test suspensions were evaluated for the redispersibility, flowability, sedimentation volume (%) and stability study for 3 months.

Result
The redispersibility of modified neem gum (MNG) was found equal to CMC at a higher concentration. The flowability and apparent sedimentation of test suspending agents and CMC were found in the order of NG > MNG > CMC. It showed a positive correlation with the viscosity of suspension formulations. All the test paracetamol suspension formulations were found stable in the stability study.

Conclusion
The findings of the present study showed that as an alternate suspending agent, modified cross-linked neem gum could be used.
Silver linings: how mental health activists can help us navigate wicked problems
Authors: Armstrong Neil , Pratt-Boyden Keira 
Published: June 2021

SummaryThis article explores how ‘wicked problems’ such as climate change might force psychiatry to rethink some of its fundamental ideas and ways of working, including clinical boundaries, understandings of psychopathology and ways of organising. We use ethnographic evidence to explore how mental health service ‘survivor’ activists are already rethinking some of these issues by therapeutically orienting themselves towards social problems and collective understandings of well-being, rejecting ‘treatment as usual’ approaches to distress. In this way we provide an example of the potential of activists to help psychiatry negotiate the climate crisis.