bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Surfactant Addition on The Physico-Chemical Properties and Stability of Virgin Coconut Oil Nanoemulsions
Authors: Trivana Linda , Suyatma Nugraha E. , Hunaefi Dase , Munarso S. Joni 
Published: July 2021

<p>Virgin coconut oil (VCO) is high quality coconut oil and categorized as the healthiest oil and functional foods. Based on these benefits, the development of a VCO in emulsion product might increase the human consumption of coconut oil because consumers dislike the only taste of pure VCO. The aim of this study was to develop the water compatible form of VCO through nano-emulsification. The effect of different types and amounts of surfactants (Tween 80 and Span 80) on the physio-chemical characteristic of emulsion containing VCO was investigated. VCO based emulsions were prepared with the aid of Ultra-Turrax homogenizer. Emulsions were developed by adding and mixing VCO with surfactants. The ratio of Tween 80 and Span 80 used were 0:10, 2.5:7.5, 5:5, 7.5:2.5, and 10:0. The droplet size of nanoemulsions consisting of Tween 80:Span 80 (0:10, 2.5:7.5, 5:5, 7.5:2.5, and 10:0) were 1.343, 0.606, 0.829, 1.439, and 2.506µm, respectively. Based on the TEM analysis and polydispersity index (PDI) &gt;0.5 showed the oil droplets are in not uniform shape, indicating a unstable emulsion. VCO emulsion with ratio Tween 80:Span 80 (0:10) obtained a homogeneous emulsion (stable) compare than that of others and w/o type emulsion. The stability of emulsion is evaluated by turbidity measurement using UV-VIS spectrophotometer with wavelength 502 nm. A combination of treatments (ambient condition, thermal treatmeant (40°C)), and centrifuge) of VCO emulsion has resulted on thermal treat, the turbidity measured from the emulsion was higher than the other emulsion, reflecting the presence of the smaller droplets in this emulsion.</p>
OPTIMIZATION OF THE ACEH BEEF CATTLE PRODUCTION AND PROCESS USING SWOT ANALYSIS AND INDUSTRIAL SUPPLY CHAIN APPROACHES
Authors: Mizan Us Khairol , Yaman M. Aman , Fradinata Edy 
Published: July 2021

The problem in management process and production of Aceh beef cattle farms in Aceh Besar has not been explored. This study aimed to determine the basic system of supply chain for the Aceh beef cattle production in Central Aceh Besar developed a model for optimizing the supply chain management and sustainability to increase productivity and business efficiency. This research used SWOT analysis and industrial supply chain approaches. The results showed that the current supply chain system of the Aceh beef cattle industry in Aceh Besar which has been running so far, needs to be strengthened to increase production and population of Aceh beef cattle in the future. There were 4 issues were identified: time, 29.6% faster than the current supply chain supply time; method, 60% no longer needed a business intermediary; cost, 21.4% of the live weight price of cattle was cheaper than the live weight price of current supply chain cattle; and stages, 30.8% shorter than the ongoing supply chain stages. The result of the SWOT analysis matrix showed that the SO (strength-opportunities) strategy was the main strategy for business developing of Aceh beef cattle in Central Aceh. In conclusion, it is necessary to optimize the implementation of the supply chain of Aceh Cattle Industry at Central Aceh by utilizing its strengths and suppressing the existing weaknesses from the breeding production to marketing process.
Evidências Psicométricas das Dimensões da Qualidade de Serviços de um Bairro Urbanco
Authors: Pastana Sheila Trícia Guedes , Formiga Nilton Soares 
Published: July 2021

Este estudo visa desenvolver e validar uma escala relacionada à qualidade dos serviços do bairro, a partir da perspectiva das pessoas que habitam as áreas sul e leste na cidade de Natal-RN. Com base no conceito e teoria da gestão urbana, marketing e satisfação residencial, o estudo apresenta escala para medir as dimensões da qualidade dos serviços no bairro como forma de contribuir para sua gestão urbana e, por conseguinte, das cidades, auxiliando no planejamento e tomada de decisão por parte dos gestores, promoção do bem-estar, qualidade de vida, serviços e ambientes urbanos acolhedores, para atrair investimentos públicos e privados. A metodologia utilizada foi do tipo quantitativo, descritivo e correlacional, através de levantamento. A coleta de dados foi feita por meio de um questionário estruturado, tendo alcançado 701 respondentes, distribuídos em quatro amostras. Para a análise dos dados adotou-se um estudo subdividido em três etapas, a saber: 1) estatística descritiva e representatividade de conteúdo, 2) análise exploratória e 3) análise confirmatória da estrutura fatorial. Os resultados revelaram que a escala Dimensões da Qualidade dos Serviços no Bairro (DQSB) é consistente em sua estrutura tetrafatorial, não havendo diferenças entre as zonas urbanas relativas à mensuração desse construto, comprovando-se assim o mesmo nível de qualidade dos serviços.
A metafluid with multistable density and internal energy states
Authors: Peretz Ofek , Abu Ezra Ben , Zigelman Anna , Givli Sefi , Gat Amir 
Published: July 2021

Abstract
The efficiency, operation range, and environmental safety of energy and refrigeration cycles are determined by the thermodynamic properties of available fluids. We here suggest combining gas, liquid and multistable elastic capsules to create an artificial fluid with a multitude of stable states. We study, theoretically and experimentally, the suspension’s internal energy, equilibrium pressure-density relations and their stability for both adiabatic and isothermal processes. We show that the elastic multistability of the capsules endows the fluid with multistable thermodynamic properties, including the ability of capturing and storing energy at standard atmospheric conditions, not found in naturally available fluids.
Utilization of galactomannan from spent coffee grounds as coagulant aid to treat synthetic Congo red wastewater
Authors: Kristianto Hans , Saraswati Sekar Astari , Prasetyo Susiana , Sugih Asaf K 
Published: July 2021

Abstract
Over the last few years, there is a significant growth in research exploring natural based coagulant due to its various benefits to decrease or even substitute the usage of inorganic chemical coagulants. Polysaccharide based coagulant and coagulant aid is a promising source for this purpose, due to its abundance. In this study, we reported utilization of galactomannan extracted from spent coffee grounds as natural coagulant aid in coagulation of Congo red synthetic wastewater. The coagulation was done at fixed dosage of FeCl3 (160 mg/L) and pH of 6. The effect of galactomannan as coagulant aid was observed by varying galactomannan dosage (0-140 mg/L) and Congo red concentration (20–70 mg/L). It was found that galactomannan as coagulant aid could increase the removal of Congo red, around 30–90% removal, depends on Congo red concentration, compared FeCl3 only (0–65%). The coagulation adsorption study was also investigated using Langmuir, Freundlich, and Brunauer – Emmet – Teller (BET) isotherm models. It was found that Congo red coagulation using FeCl3 only was following Langmuir isotherm, indicating monolayer – homogenous formation during the coagulation. On the other hand, with the presence of galactomannan the coagulation was best described by BET isotherm, indicating multilayer – heterogeneous adsorption, possibly due to interparticle bridging of galactomannan during colloid aggregation. The findings in this study suggest synergistic effect of galactomannan and FeCl3 in the coagulation process and proved potential of galactomannan from spent coffee grounds as natural coagulant aid.
NaYS2:Er3+ - a highly efficient NIR II response multi-photon up-conversion phosphor
Authors: Yin Xiumei , Xu Wen , Zhu Ge , Ji Yanan , Xiao Qi , Dong Xinyao , He Ming , Cao Baosheng , Zhou Na , Luo Xixian , Guo Lin , Dong Bin 
Published: July 2021

Abstract
The second near-infrared (NIR II) response photon up-conversion (UC) materials show great application prospects in the fields of biology and optical communication. However, it is still an enormous challenge to obtain efficient NIR II response materials. Herein, we developed a series of Er3+ doping ternary sulfides phosphors with highly efficient UC emissions under 1532 nm irradiation. Excitingly, β-NaYS2:Er3+ achieves a breakthrough visible UC efficiency as high as 6.13%, along with outstanding brightness, spectral stability of lights illumination and temperature. Such efficient UC dominates by excited state absorption process accompanied by the advantage of super long lifetimes of excited state levels of Er3+, instead of the well-recognized energy transfer UC between sensitizer and activator. NaYS2:Er3+ phosphors are further developed for high-performance underwater communication and a narrowband NIR photodetectors. Our findings breakthrough the traditional thinking of realizing efficient UC, and open up a novel frontier for developing NIR II response UC materials.
Application of Broccoli Residues to Soil can Suppress Verticillium Wilt of Cotton by Regulating the Bacterial Community Structure of the Rhizosphere
Authors: Zhao Weisong , Guo Qinggang , Li Shezeng , Lu Xiuyun , Wang Peipei , Dong Lihong , Zhang Xiaoyun , Su Zhenhe , Ma Ping 
Published: July 2021

Abstract
[Aims] Verticillium wilt (VW) of cotton was effectively controlled by application of broccoli residues (BR) to soil. Information regarding the variation in bacterial communities in rhizosphere of cotton cultivars with different VW resistance levels under BR treatment is still lacking and finally to provide guidance for screening effective biocontrol bacteria. [Methods] Real-time fluorescence quantitative PCR was used to determine the population of Verticillium dahliae, the effects of BR on the bacterial community structure in rhizosphere were determined by high-throughput sequencing technology. [Results] Results showed that control effects for susceptible cultivar (cv. EJ-1) and resistant cultivar (cv. J863) on VW after BR treatment were 51.76% and 86.15%, the population of V. dahliae decreased by 18.88% and 30.27%, respectively. High-throughput sequencing showed that ACE and Chao1 indices were increased by application of BR. Actinobacteria, Proteobacteria, Bacteroidetes, Gemmatimonadetes, Acidobacteria, and Firmicutes were the most dominant phyla, and relative abundances of these bacterial taxa significantly differed between cultivars. Additionally, Bacillus stably increased in rhizosphere following BR treatment. Redundancy analysis (RDA) showed that relative abundances of Bacillus, Lysobacter, Streptomyces, Rubrobacter, Gemmatimonas, Bryobacter and Nocardioides were correlated with occurrence of VW. Field experiments demonstrated that dressing cotton seeds with Bacillus subtilis NCD-2 could successfully reduce occurrence of VW, and control effects for EJ-1 and J863 were 35.26% and 31.02%, respectively. [Conclusions] The application of BR changed the bacterial community structure in cotton rhizosphere, decreased the population of V. dahliae in soil, and increased the abundance of beneficial microorganisms, thus significantly reducing the occurrence of VW.
Upregulated Serum Granulysin Levels in Women With Antiphospholipid Syndrome-Associated Recurrent Miscarriages Are Downregulated by Heparin Treatment
Authors: Ichikawa Tomoko , Negishi Yasuyuki , Kasano Sayuri , Yokote Ryoko , Yonezawa Mirei , Ouchi Nozomi , Kuwabara Yoshimitsu , Takeshita Toshiyuki 
Published: July 2021

Abstract
Background

Antiphospholipid antibody syndrome is the major cause of recurrent pregnancy loss (RPL) and associated with inflammation. Granulysin is a cytotoxic protein secreted by cytotoxic T cells, natural killer cells, and natural killer T cells that is present in abundance in the decidua. It activates innate and cellular immunity simultaneously, and also induces miscarriage. As a treatment, heparin is widely used for the patients with RPL, and exhibits the antithrombotic and anti-inflammatory activities, and angiogenesis.
Methods

We hypothesized that granulysin is an important factor in inducing miscarriage. Here, we evaluated the changes of serum granulysin level before and 1 week after the commencement of heparin treatment for the patients with RPL.
Results

The serum granulysin levels before heparin treatment were significantly higher in women who tested positive for one or more types of antiphospholipid antibody (2.75 ± 1.03 vs. 2.44 ± 0.69; P = 0.0341 by Welch’s t-test), particularly anti-phosphatidylethanolamine antibodies (IgG: 2.98 ± 1.09 vs. 2.51 ± 0.86; P = 0.0013, IgM: 2.85 ± 1.09 vs. 2.47 ± 0.77; P = 0.0024 by Welch’s t-test). After heparin treatment for 1 week, the serum granulysin levels were reduced significantly (P = 0.0017 by paired t-test). The miscarriage rate was significantly higher in women whose serum granulysin levels were not reduced by heparin treatment (P = 0.0086 by Fisher’s exact probability test).
Conclusions

These results suggest that heparin may reduce the incidence of miscarriages by suppressing the serum granulysin levels.
TopFuzz4SA: An Integrated Fuzzy Neural Network with Topic-aware Auto-encoding for Sentiment Analysis
Authors: Vo Tham 
Published: July 2021

Abstract
Recent advanced deep learning architectures, such as neural seq2seq, transformer, etc. have demonstrated remarkable improvements in multi-typed sentiment classification tasks. Even though recent transformer-based and seq2seq-based models have successfully enabled to capture rich-contextual information of texts, they are still lacking of attention on incorporating the global semantic information, such as topic, in order to sufficiently leverage the performance of downstream SA task. Moreover, emotional expressions of users are normally in forms of natural human-written textual data which might consist a lot of noise and ambiguity which impose great challenges on the processes of textual representation learning as well as sentiment polarity prediction. To meet these challenges, we propose a novel integrated fuzzy-neural architecture with a topic-driven textual representation learning approach for handling SA task, called as: TopFuzz4SA. Specifically, in the proposed TopFuzz4SA model, we first apply a topic-driven neural encoder-decoder architecture with the incorporation of latent topic embedding and attention mechanism to sufficiently learn both rich contextual and global semantic information of the given textual data. Then, the achieved rich semantic representations of texts are fed into a fused deep fuzzy neural network to effectively reduce the feature ambiguity and noise, forming the final textual representations for sentiment classification task. Extensive experiments in benchmark datasets demonstrate the effectiveness of our proposed TopFuzz4SA model in comparing with contemporary state-of-the-art baselines.
Oxidative Stress Is Involved In The Activation of NF-κB Signal Pathway And Immune Inflammatory Response In Grass Carp Gill Induced By Cypermethrin And/Or Sulfamethoxazole Exposure
Authors: Li Baoying , Wang Yu , Zhao Hongjing , Yin Kai , Liu Yachen , Wang Dongxu , Zong Hui , Xing Mingwei 
Published: July 2021

Abstract
At present, the concentration of environmental pollutants, such as pesticides and antibiotics exposed in environment, especially in aquatic environment is increasing. These contaminants are exposed through aquatic environment to fish and ultimately accumulate in humans. Research on environmental pollutants has exploded in the past two years. However, there are still few studies on the combined effects of pesticides and antibiotics on fish, especially on fish gills. A separate analysis of the toxic effects caused by an environmental pollutant cannot fully show the real situation. In this paper, cypermethrin (CMN) and sulfamethoxazole (SMZ) were analyzed and found that there was a strong correlation between the pathways affected by the first 30 genes regulated by CMN and SMZ respectively. Therefore, the toxic effects of CMN (0.651 μg/L) and/or SMZ (0.3 μg/L) on grass carp gill were studied in this paper. Histopathology, quantitative real-time PCR and other methods were used to detect the tissue morphology, oxidative stress level, inflammation and apoptosis-related indicators of the fish gills after exposure 42 days. It was found that compared with the single exposure (SMZ/CMN) group, the combined exposure (MIX) group had a more pronounced oxidative stress index imbalance. At the same time, nuclear factor-κB (NF-κB) signal pathway was activated and immuno-inflammatory reaction appeared in MIX group. This study reveals the harm of CMN and SMZ to fish, and provides a reference and basis for the rational use of pesticides and antibiotics.
Lamellar thickness in semicrystalline polymers as a result of the competition between crystal growth and intracrystalline chain dynamics
Authors: Schulz Martha , Schäfer Mareen , Saalwächter Kay , Thurn-Albrecht Thomas 
Published: July 2021

Abstract
The non-equilibrium thickness of lamellar crystals in semicrystalline polymers varies largely between different polymer systems and depends on the crystallization temperature Tc. There is currently no consensus on the mechanism of thickness selection. Previous work has highlighted the decisive role of intracrystalline chain dynamics (ICD) in special cases, but a systematic dependence of lamellar thickness on relevant timescales such as that of ICD and stem attachment has not yet been established. Studying the morphology by small-angle X-ray scattering and the two timescales by NMR methods and polarization microscopy, we here present data on poly(oxymethylene), a case with comparably slow ICD. It fills the gap between previously studied cases of absent and fast ICD, enabling us to establish for the first time a quantitative dependence of lamellar thickness on the competition between the noted timescales.
Ultrastructural Analysis of Apoptosis Induced By Zinc Oxide Nanosphere in Human Hepatoma Huh7 Through Mitochondria Dysfunction
Authors: Hassan Amr , Abuamara Tamer M.M. , Matar Emadeldin R. , Aboulthana Wael M. , baz Hatim A. El- , Zoair Mohammad A. , Mohamed Aly Fahmy , Maksoud Ahmed I. Abd El 
Published: July 2021

Abstract
The efficiently of hepatocellular carcinoma therapy predominantly depends on advancement of nanomedicine. Zinc oxide nanostructure is promising material in nanomdicine field due to their unique properties. Zinc oxide Nanosphere (ZnO Ns) was fabricated with a size 50 nm diameter by a developed Sol-gel approach, using non-toxic biotemplate yeast extract. The physicochemical properties of zinc oxide nanosphere were estimated by Fourier-transform infrared spectrum (FTIR), X-ray diffraction (XRD), dynamic light scattering (DLS), and transmission electron microscope (TEM). Liberated zinc ions released from the zinc oxide nanosphere suspended medium was determined by ICP-AS. The viability was tested by using HuH7 and Vero cells.ZnO nanosphere was more effectively on cell line than released Zn ions. The cell cycle arrested at G1/S. Also, the apoptosis assay by using Annexin-V/PI showed that apoptosis of HuH7 by ZnO nanosphere is concentration and time-dependent. The mechanism of apoptosis was evaluated via using techniques such as RT-PCR and flow cytometry. The results revealed significance up-regulated of Bax, P53, and Cytochrome C, while a Bcl2 results displayed significance down-regulated.Caspase 3 assay results showed that the apoptosis mechanism was intrinsic and extrinsic pathways. Also, ZnO nanosphere and free Zn+2 ions induced oxidative stress via increasing reactive oxygen species (ROS) and lipid peroxidation. The ultrastructural analysis of HuH7 cell was occurred by TEM.Transmission electron microscope analysis of HuH7 after treated with ZnO nanosphere at different times revealed a chromatin condensation of the nuclear periphery fragmentation appearance. Interestingly, the apoptosis of HuH7 cells induced by Zinc oxide nanosphere, showed the canonical ultrastructure features of apoptotic nuclei, and fragmented by budding. Furthermore, There were many vacuoles that filled in the cytoplasm, majority lipid droplets, which resembling those observed in foamy cells, and vesicles with intact membranes, which were recognized as swollen mitochondria.
Accompanying the Prostate Cancer Patient Pathway: Evaluation of Novel Clinical Decision Support Software
Authors: Henkel Maurice , Horn Tobias , Leboutte Francois , Trotsenko Pawel , Dugas Sarah G. , Sutter Sarah Ursula , Ficht Georg , Engesser Christian , Matthias Marc , Stalder Aurelien F. , Ebbing Jan , Cornford Philip , Seifert Helge , Stieltjes Bram , Wetterauer Christian 
Published: July 2021

Abstract
Introduction Physicians spend more than half of their workday interacting with health information systems to care for their patients. Effective data management that provides physicians with comprehensive patient information from various information systems is required to ensure high quality clinical decision making.Objectives We evaluated the impact of a novel, CE-certified clinical decision support tool on physician’s effectiveness and satisfaction in the clinical decision-making process.Methods Using pre-therapeutic prostate cancer management cases, we compared physician’s expenditure of time, data quality, and user satisfaction in the decision-making process comparing the current standard with the software. Ten urologists from our department conducted the diagnostic work-up to the treatment decision for a total of 10 patients using both approaches.Results A significant reduction in the physician’s expenditure of time for the decision-making process by -59.9 % (p < 0,001) was found using the software. System usage showed a high positive effect on evaluated data quality parameters completeness (Cohen's d of 2.36), format (6.15), understandability (2.64), as well as user satisfaction (4.94).Conclusion The software demonstrated that effective data management can improve physician’s effectiveness and satisfaction in the clinical decision-making process. Further development is needed to map more complex patient pathways, such as the follow-up treatment of prostate cancer.