bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teaching Business Transaction Cycles Using a Hands-On Activities Approach
Authors: Wang Tawei , Chiu Victoria , Wang Yunsen , Chiu Tiffany 
Published: November 2021

ABSTRACT
We present a novel hands-on approach for teaching students the concepts and business processes of transaction cycles. Specifically, the hands-on activities focus on sales and procurement cycles. Upon completion of the hands-on activities, students will (a) develop a better understanding of the business processes and business forms for sales and procurement cycles and (b) build relevant critical thinking skills. We evaluate students' learning by providing a comparison between students who learned the concepts of transaction cycles and business processes and performed the transaction cycle hands-on activity in class versus those students who only learned the concepts of transaction cycles and business processes in class. Although the hands-on activities were used in an accounting information systems class, they can also be applied to other business disciplines, such as engineering and project management classes.
Financial Reporting, Auditing, Analyst Scrutiny, and Investment Efficiency
Authors: Chan Derek K. W. , Liu Nanqin 
Published: November 2021

ABSTRACT
This paper presents an economic framework to study strategic interactions along the analyst-auditor-owner disciplinary chain, in which the auditor examines the financial reports prepared by the owner, and the analyst uncovers financial misreporting, as well as audit failure. We find that although analyst scrutiny ex post detects misreporting, it ex ante aggravates the owner's misreporting behavior and further impairs financial statement reliability if the legal penalties for the auditor and the owner are small. We also show how the effects of a regulation depend on its target's disciplinarian(s). Specifically, (1) although enhancing the auditor's legal liability always increases audit quality and financial statement reliability, it decreases investment efficiency if and only if the analyst is highly independent, and (2) increasing the owner's misreporting penalty decreases investment efficiency if and only if either of (but not both) the regulations on the auditor and the analyst are strict.
JEL Classifications: M41; M42; M48.
Emotional Correlates of the COVID-19 Pandemic in Individuals With and Without Diabetes
Authors: Myers Barbara A. , Klingensmith Rachel , de Groot Mary 
Published: November 2021

OBJECTIVE
To compare the mental health experiences associated with coronavirus disease 2019 (COVID-19) in adults with and without diabetes.

RESEARCH DESIGN AND METHODS
Between 29 May 2020 and 30 June 2020, 2,176 U.S. adults completed an online survey including demographics, COVID-19 experiences, depression (eight-item Patient Health Questionnaire) and anxiety (seven-item Generalized Anxiety Disorder) symptoms, perceived stress (10-item Perceived Stress Scale), resilience (Brief Resilience Scale), and diabetes-related distress (in participants with diabetes) (17-item Diabetes Distress Scale).

RESULTS
Mean age was 49.6 years (SD 16.9); participants were primarily women (80.0%) and White (88.3%), with an annual household income of ≥$60,000 (57.6%). One hundred reported a diagnosis of type 1 diabetes (4.6%), 304 type 2 diabetes (13.9%), and 145 prediabetes (6.6%). Nearly one-third (29.7%) indicated decreases in income attributable to the pandemic. Participants with type 1 diabetes had higher levels of diabetes distress than participants with type 2 diabetes (P &lt; 0.05), with moderate severity in both groups. Participants with type 2 diabetes had significantly more comorbidities and COVID-19 risk factors than all other groups (all P &lt; 0.01). After controlling for covariates, participants with type 2 diabetes reported significantly more depressive symptoms than those without diabetes (P &lt; 0.05) and lower levels of resilience (P &lt; 0.05). Subgroup analyses by sex and age indicated that women and younger adults, particularly those age 18–34 years, reported significantly more depression and anxiety symptoms, stress, and diabetes-related distress and lower levels of resilience than men and adults age ≥51 years.

CONCLUSIONS
In this naturalistic observational study, participants with type 2 diabetes reported more depression, lower resilience, and significantly more COVID-19 risk factors and medical comorbidities than participants without diabetes. Overall, our participants demonstrated worse depression and anxiety symptoms during compared with before the pandemic.
PENYULUHAN TENTANG KUALITAS TIDUR PADA MASA PANDEMI COVID-19
Authors: Sulistyani Sulistyani 
Published: November 2021

ABSTRAK
Pandemi COVID-19 menimbulkan berbagai masalah kesehatan masyarakat di seluruh dunia, salah satunya adalah trauma psikis yang dapat mempengaruhi kualitas tidur. Kualitas tidur sulit untuk didefinisikan namun dapat diidentifikasi dengan istrumen penilaian PSQI Pittsburgh Sleep Quality Index). Kualitas tidur yang baik mempunyai peran penting dalam meningkatkan fungsi kognitif terutama retensi memori. Kualitas tidur malam yang buruk menyebabkan kantuk di siang hari dapat mempengaruhi kesehatan fisik dan kognitif pada pelajar atau mahasiswa siswa dan mempengaruhi nilai akademik. Tujuan penyuluhan ini adalah untuk meingkatkan pengetahuan tentang kualitas tidur yang baik. Hasil penyuluhan terdapat 60% gangguan tidur pada peserta penyuluhan dan terdapat peningkatan pengetahuan tentang kualitas tidur. Simpulan yang dapat diambil adalah penyuluhan dapat meningkatkan pengetahuan tentang kualitas tidur yang baik.

ABSTRACT
The COVID-19 pandemic causes psychological trauma. It has an impact on sleep quality. PSQI (Pittsburgh Sleep Quality Index assessment instrument) is the instrument to identify sleep quality disorders. Good quality sleep can improve cognitive function, particularly memory retention. A poor night's sleep quality causes daytime sleepiness and affects physical, cognitive health, and academic grades. The purpose of the counseling is to increase knowledge about good sleep quality. There were 60% sleep disorders in counseling participants and an increase in knowledge about sleep quality. The conclusion is counseling can increase knowledge about good sleep quality.
Pengaruh Bauran Promosi, Harga, Display Produk dan Kualitas Layanan terhadap Keputusan Pembelian pada Apotek Anugerah Farma di Kota Gorontalo
Authors: Suyanto Mohamad Afan , M Muh Akmar , Karundeng Deby Rita 
Published: November 2021

The research aims to determine the effect of: Promotion Mix on Purchasing Decisions, Prices on Purchasing Decisions, Product Display on Purchasing Decisions, Service Quality on Purchasing Decisions at Anugerah Farma Pharmacy in Gorontalo City and to determine the Effect of Promotion Mix, Price, Product Display and Service Quality on Purchasing Decision at Anugerah Farma Pharmacy in Gorontalo City
This research approach is a qualitative descriptive approach. This type of research is a survey, namely analyzing the facts that support the information needed to support the research discussion, in solving and answering the main problems posed. The data were obtained through distributing questionnaires, then the data were analyzed descriptively and multiple regression analysis.
The results showed that partially the promotion mix had a positive and significant effect on purchasing decisions. Price has a positive and insignificant effect on the decision. Product display has a positive and significant effect on purchasing decisions. Service quality has a positive and significant effect on purchasing decisions at Anugerah Farma Pharmacy and simultaneously the promotion mix, price, product display and service quality have a positive and significant effect on purchasing decisions at Anugerah Farma Pharmacy, Gorontalo City.
The Role of Nano-Silicon and Other Soil Conditioners in Improving Physiology and Yield of Drought Stressed Barley Crop
Authors: Mahmoud Abdel Wahab M. , Hassan A.Z.A , Mottaleb Shady Abdel , Rowezak Mohamed M. , Salama Azza M. 
Published: November 2021

Abstract
A field experiment was conducted in sandy soil to assess the effect of different sources of soil conditioners on barley (Hordeum vulgare L. cv. Giza 137) growth and its yield under drought stress. Plants were exposed to two levels of drought stress until grain maturity: (A) drought at 75% available water (AW) with NPK as control (treatment, T1); (B) mild drought stress at 50% AW with foliar spray of nano-silicon at 75 ppm (treatment, T2), foliar spray of nano-zeolite at 75 ppm (treatment, T3), perlite at 4 tons/h (treatment, T4), natural zeolite at 600 kg/ha (treatment, T5), bentonite at 4 tons/h (treatment, T6), and a combined treatment of T2+T3+T4+T5+T6 at the half amount of each material (T7). All the treatments received the recommended doses of organic matter. Vegetative growth and yield characters as well as anatomical characters were recorded. The physical and chemical soil properties were significantly improved by both foliar and soil conditioners application. The nutrients content of the barley crop were augmented under combined treatment (T7) as compared to other treatments. Under that treatment, barley crop chemical components, i.e. protein, ash, chlorophylls, amino acids, vitamins, and fibre were significantly higher compared to other treatments. In addition, gibberellic acid (GA3) and abscisic acid (ABA) content besides antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD) activities were significantly affected by all treatments. The economical profits were achieved, as reflected by an investment factor value equal to or higher than 3, and this was achieved for all tested nanosilicon, zeolite, and soil conditioners indicated the effectiveness and profitability of studied treatments.
Type I interferon therapies of multiple sclerosis and hepatitis C virus infection
Authors: Jasyk Izabella , Siednienko Jakub 
Published: November 2021

Abstract
Interferons type I (IFN-I), activated following a bacterial or viral infection, play a major role in the induction and regulation of the immune system. The immune response results in viral RNA and binds to receptors such as RIG-I-like receptors (RLRs) or Toll-like receptors, leading to the IFN-I signaling cascade. Thanks to its cellular function, IFN-I is widely used in therapies for such diseases as multiple sclerosis (MS) and hepatitis C disease (HCD).
MS is a neurological, autoimmune, chronic inflammatory disease of the central nervous system (CNS). During MS, nerve cell demyelination is observed due to the myelin heaths and oligodendrocyte damage. As a result, neuronal signal and neuron communication are attenuated. The mechanism of MS is still unknown. MS therapy applies interferon-β (IFN-β). IFN-β therapy has been used since the last century, but the therapeutic mechanism of IFN-β has not been completely understood. MS can lead to four syndromes: clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), primary progressive MS (PPMS), and secondary progressive MS (SPMS).
HCD occurs as a result of infection with the hepatitis C virus (HCV), belonging to the Flaviviridae family. HCV is a blood-borne virus with a positive single-stranded RNA. A vaccine for HCV is not available yet. HCD can lead to liver damage or cancer. In HCD interferon-α therapy (IFN-α) is applied. As with MS, the mechanism of IFN-α therapy is not completely known.
Kobalamina – właściwości biomedyczne i niedobór w ujęciu biochemicznym
Authors: Rzepka Zuzanna , Słaby Daniel , Wrześniok Dorota 
Published: November 2021

Abstrakt
Kobalamina (witamina B12) jest rozpuszczalnym w wodzie związkiem organicznym, zaliczanym do witamin grupy B. Złożona budowa i polarność cząsteczki witaminy B12 sprawiają, że do jej prawidłowego wykorzystania i przemian w organizmie człowieka niezbędny jest udział wyspecjalizowanych białek. Głównym źródłem kobalaminy człowieka jest pokarm pochodzenia zwierzęcego. Ze względu na rezerwy tkankowe tej witaminy, jej niedobór ujawnia się dopiero po kilku latach niewystarczającej podaży z pożywieniem. Badania przesiewowe pod kątem deficytu kobalaminy są jednak uzasadnione u osób z czynnikami ryzyka hipokobalaminemii, takimi jak: stan po resekcji żołądka lub jelita cienkiego, dieta wegańska, długotrwałe stosowanie metforminy, antagonistów receptora histaminowego H2 oraz leków z grupy inhibitorów pompy protonowej, a także podeszły wiek.
Witamina B12 jako kofaktor enzymatyczny uczestniczy w licznych przemianach wewnątrzmitochondrialnych oraz w syntezie metioniny, niezbędnej do powstania S-adenozylometioniny istotnej w procesie metylacji cząsteczek biologicznie czynnych. Przez powiązania metaboliczne z kwasem foliowym kobalamina wpływa na proces syntezy DNA i podział komórki. Obecnie coraz częściej zwraca się uwagę na potencjalny udział niedoboru witaminy B12 w patogenezie chorób neurodegeneracyjnych, a także nowotworowych. Niedobór kobalaminy na poziomie molekularnym destabilizuje genom komórek, zwiększając ryzyko ich złośliwej transformacji. Jednak u osób z chorobą nowotworową lub obciążonych ryzykiem jej rozwoju witamina B12 może nasilać ekspansję komórek neoplastycznych.
Evolution of Australasian Plantago (Plantaginaceae)
Authors:   , Tay Mei Lin 
Published: November 2021

<p>Phylogenetic analyses using molecular data were used to investigate biogeographic and evolutionary patterns of Australasian Plantago. The Internal Transcribed Spacers (ITS) from nuclear DNA, ndhF-rpl32 from chloroplast DNA and cox1 from mitochondrial DNA were selected from a primer assay of 24 primer pairs for further phylogenetic analyses. Phylogenetic reconstruction and molecular dating of a dataset concatenated from these regions comprising 20 Australasian Plantago species rejected a hypothesis of Gondwanan vicariance for the Australasian group. The phylogeny revealed three independent dispersal events from Australia to New Zealand that match expected direction because of West Wind Drift and ocean currents. Following this study, a dataset with 150 new ITS sequences from Australasian Plantago, combined with 89 Plantago sequences from previous studies, revealed that the New Zealand species appear to have a recent origin from Australia, not long after the formation of suitable habitats formed by the uplift of the Southern Alps (about 5 mya), followed by radiation. The ITS phylogeny also suggests that a single migration event of alpine species to lowland habitats has occurred and that recurrent polyploidy appears to be an important speciation mechanism in the genus. Species boundaries between New Zealand Plantago were unclear using both morphological and molecular data, which was a result of low genetic divergences and plastic morphology. The taxonomy of several New Zealand Plantago species need revision based on the ITS phylogeny.</p>
PENGARUH IMPLEMENTASI MODEL PEMBELAJARAN PROBLEM SOLVING DIPADUKAN DENGAN KETERAMPILAN HOTS TERHADAP HASIL BELAJAR PESERTA DIDIK BERDASARKAN STUDI LITERATUR
Authors: Mari’a Hani’am , Ismono Ismono 
Published: November 2021

Artikel ini disusun dengan tujuan untuk mengetahui pengaruh implementasi model pembelajaran problem solving terhadap hasil belajar peserta didik jika dipadukan dengan keterampilan HOTS berdasarkan studi literatur. Studi terdahulu mengungkapkan bahwa keterampilan HOTS peserta didik tergolong rendah. Guru berperan penting memberikan inovasi baru disetiap kegiatan pembelajaran salah satunya yaitu dengan memilih model pembelajaran yang tepat, karena model pembelajaran yang diterapkan guru akan berpengaruh terhadap hasil belajar peserta didik. Hasil belajar merupakan faktor penting dalam proses pembelajaran karena menjadi salah satu tolak ukur keberhasilan pendidikan. Model pembelajaran yang cocok dengan keterampilan HOTS salah satunya yakni model pembelajaran problem solving. Penelitian ini dikaji melalui metode meta analisis dengan mengumpulkan beberapa data dari studi literatur penelitian yang setema. Hasil analisis studi literatur menyatakan bahwa model pembelajaran problem solving berpengaruh terhadap hasil belajar peserta didik dalam meningkatkan keterampilan HOTS dibuktikan dengan nilai posttest yang diperoleh peserta didik dengan rata-rata peningkatan nilai posttest peserta didik sebesar 22,87%. Berdasarkan data yang telah dipaparkan pada pembahasan dapat disimpulkan bahwa implementasi model pembelajaran problem solving jika dipadukan dengan keterampilan HOTS dapat memberikan pengaruh terhadap hasil belajar peserta didik serta dapat meningkatkan motivasi belajar peserta didik.
Kata kunci: Problem Solving, Keterampilan HOTS, Hasil Belajar, Studi Literatur
Analysis of The Potential Banana Prawn (Penaeus merguiensis) in The Northern Waters of Rembang Regency
Authors: Umam Muhamad Fathikul , Suherman Agus , Prihantoko Kukuh Eko 
Published: November 2021

This study aims to describe the characteristics of mini bottom trawl fishing gear and fishing season, as well as to estimate the stock density and sustainable potential of banana prawn (Penaeus merguiensis), in Rembang Regency. This study was conducted from September to October 2020, in the Northern Waters of Rembang Regency, with an area of ​​1409.7 km², using both primary and secondary data. Primary data was collected directly from observations, measurements, and interviews with fishermen, while secondary data, including data on the number and types of fishing gear, as well as production and production values, was obtained through a literature review. The results of the study found that banana prawn in the northern waters of Rembang Regency was caught using two types of fishing gear, and these are sotok/mini bottom trawls and trammel nets. The total length of mini bottom trawl in this study are 15.77 m, 16.5 m, 20.44 m, and 25.2 m. The fishing season for banana prawn is from June to September The average stock density value is 16.22 kg/km² (range 4.37 to 41.14 kg/km²), the Cmsy value is 2.625 kg, the Emsy value is 4.172 trips and the average utilization rate is 44% (range 23 to 82%).
Keywords: Rembang, banana prawn, stock density, and MSY.
Predicting pituitary adenoma consistency with preoperative magnetic resonance elastography
Authors: Cohen-Cohen Salomon , Helal Ahmed , Yin Ziying , Ball Matthew K. , Ehman Richard L. , Van Gompel Jamie J. , Huston John 
Published: November 2021

OBJECTIVE
Pituitary adenoma is one of the most common primary intracranial neoplasms. Most of these tumors are soft, but up to 17% may have a firmer consistency. Therefore, knowing the tumor consistency in the preoperative setting could be helpful. Multiple imaging methods have been proposed to predict tumor consistency, but the results are controversial. This study aimed to evaluate the efficacy of MR elastography (MRE) in predicting tumor consistency and its potential use in a series of patients with pituitary adenomas.

METHODS
Thirty-eight patients with pituitary adenomas (≥ 2.5 cm) were prospectively evaluated with MRI and MRE before surgery. Absolute MRE stiffness values and relative MRE stiffness ratios, as well as the relative ratio of T1 signal, T2 signal, and diffusion-weighted imaging apparent diffusion coefficient (ADC) values were determined prospectively by calculating the ratio of those values in the tumor to adjacent left temporal white matter. Tumors were classified into three groups according to surgical consistency (soft, intermediate, and firm). Statistical analysis was used to identify the predictive value of the different radiological parameters in determining pituitary adenoma consistency.

RESULTS
The authors included 32 (84.21%) nonfunctional and 6 (15.79%) functional adenomas. The mean maximum tumor diameter was 3.7 cm, and the mean preoperative tumor volume was 16.4 cm3. Cavernous sinus invasion was present in 20 patients (52.63%). A gross-total resection was possible in 9 (23.68%) patients. The entire cohort’s mean absolute tumor stiffness value was 1.8 kPa (range 1.1–3.7 kPa), whereas the mean tumor stiffness ratio was 0.66 (range 0.37–1.6). Intraoperative tumor consistency was significantly correlated with absolute and relative tumor stiffness (p = 0.0087 and 0.007, respectively). Tumor consistency alone was not a significant factor for predicting gross-total resection. Patients with intermediate and firm tumors had more complications compared to patients with soft tumors (50.00% vs 12.50%, p = 0.02) and also had longer operative times (p = 0.0002).

CONCLUSIONS
Whereas other MRI sequences have proven to be unreliable in determining tumor consistency, MRE has been shown to be a reliable tool for predicting adenoma consistency. Preoperative knowledge of tumor consistency could be potentially useful for surgical planning, counseling about potential surgical risks, and estimating the length of operative time.
Multiple predictors of in-stent restenosis after stent implantation in symptomatic intracranial atherosclerotic stenosis
Authors: Yu Ying , Yan Long , Lou Yake , Cui Rongrong , Kang Kaijiang , Jiang Lingxian , Mo Dapeng , Gao Feng , Wang Yongjun , Lou Xin , Miao Zhongrong , Ma Ning 
Published: November 2021

OBJECTIVE
This study aimed to identify predictors of intracranial in-stent restenosis (ISR) after stent placement in symptomatic intracranial atherosclerotic stenosis (ICAS).

METHODS
The authors retrospectively collected data from consecutive patients who suffered from symptomatic ICAS and underwent successful stent placement in Beijing Tiantan hospital. Eligible patients were classified into “ISR,” “indeterminate ISR,” or “no-ISR” groups by follow-up digital subtraction angiography or CT angiography. A multivariate logistic regression model was used to explore the predictors of intracranial ISR after adjustments for age and sex. In addition, ISR and no-ISR patients were divided into two groups based on the strongest predictor, and the incidence of ISR, recurrent stroke, and symptomatic ISR was compared between the two groups.

RESULTS
A total of 511 eligible patients were included in the study: 80 ISR, 232 indeterminate ISR, and 199 no-ISR patients. Elevated high-sensitivity C-reactive protein (hs-CRP; odds ratio [OR] 4.747, 95% confidence interval [CI] 2.253–10.01, p < 0.001), Mori type B and C (Mori type B vs Mori type A, OR 3.119, 95% CI 1.093–8.896, p = 0.033; Mori type C vs Mori type A, OR 4.780, 95% CI 1.244–18.37, p = 0.023), coronary artery disease (CAD; OR 2.721, 95% CI 1.192–6.212, p = 0.017), neutrophil/lymphocyte ratio (NLR; OR 1.474 95% CI 1.064–2.042, p = 0.020), residual stenosis (OR 1.050, 95% CI 1.022–1.080, p = 0.001) and concurrent intracranial tandem stenosis (OR 2.276, 95% CI 1.039–4.986, p = 0.040) synergistically contributed to the occurrence of intracranial ISR. Elevated hs-CRP (hs-CRP ≥ 3 mg/L) was the strongest predictor for ISR, and the incidence of ISR in the elevated hs-CRP group and normal hs-CRP group (hs-CRP < 3 mg/L) was 57.14% versus 21.52%, respectively, with recurrent stroke 44.64% versus 16.59%, and symptomatic ISR 41.07% versus 8.52%.

CONCLUSIONS
Elevated hs-CRP level, NLR, residual stenosis, Mori type B and C, CAD, and concurrent intracranial tandem stenosis are the main predictors of intracranial ISR, and elevated hs-CRP is crucially associated with recurrent stroke in patients with symptomatic ICAS after intracranial stent implantation.