bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impairments of cortico-cortical connectivity in fine tactile sensation after stroke
Authors: Zhou Sa , Huang Yanhuan , Jiao Jiao , Hu Junyan , Hsing Chihchia , Lai Zhangqi , Yang Yang , Hu Xiaoling 
Published: February 2021

AbstractBackgroundFine tactile sensation plays an important role in motor relearning after stroke. However, little is known about its dynamics in post-stroke recovery, principally due to a lack of effective evaluation on neural responses to fine tactile stimulation. This study investigated the post-stroke alteration of cortical connectivity and its functional structure in response to fine tactile stimulation via textile fabrics by electroencephalogram (EEG)-derived functional connectivity and graph theory analyses.MethodWhole brain EEG was recorded from 64 scalp channels in 8 participants with chronic stroke and 8 unimpaired controls before and during the skin of the unilateral forearm contacted with a piece of cotton fabric. Functional connectivity (FC) was then estimated using EEG coherence. The fabric stimulation induced FC (SFC) was analyzed by a cluster-based permutation test for the FC in baseline and fabric stimulation. The functional structure of connectivity alteration in the brain was also investigated by assessing the multiscale topological properties of functional brain networks according to the graph theory.ResultsIn the SFC distribution, an altered hemispheric lateralization (HL) (HL degree, 14%) was observed when stimulating the affected forearm in the stroke group, compared to stimulation of the unaffected forearm of the stroke group (HL degree, 53%) and those of the control group (HL degrees, 92% for the left and 69% for the dominant right limb). The involvement of additional brain regions, i.e., the distributed attention networks, was also observed when stimulating either limb of the stroke group compared with those of the control. Significantly increased (P < 0.05) global and local efficiencies were found when stimulating the affected forearm compared to the unaffected forearm. A significantly increased (P < 0.05) degree of inter-hemisphere FC (interdegree) mainly within ipsilesional somatosensory region and a significantly diminished degree of intra-hemisphere FC (intradegree) (P < 0.05) in ipsilesional primary somatosensory region were observed when stimulating the affected forearm, compared with the unaffected forearm.ConclusionsThe alteration of cortical connectivity in fine tactile sensation post-stroke was characterized by the compensation from the contralesional hemisphere and distributed attention networks related to involuntary attention. The interhemispheric connectivity could implement the compensation from the contralateral hemisphere to the ipsilesional somatosensory region. Stroke participants also exerted increased cortical activities in fine tactile sensation.
The yearly financing need of providing paid maternity leave in the informal sector in Indonesia
Authors: Siregar Adiatma Y. M. , Pitriyan Pipit , Hardiawan Donny , Zambrano Paul , Vilar-Compte Mireya , Belismelis Graciela Ma Teruel , Moncada Meztli , Tamayo David , Carroll Grace , Perez-Escamilla Rafael , Mathisen Roger 
Published: February 2021

AbstractBackgroundThe economic cost of not breastfeeding in Indonesia is estimated at US$1.5–9.4 billion annually, the highest in South East Asia. Half of the 33.6 million working women of reproductive age (WRA) in Indonesia (15–49 years) are informal employees, meaning they are working as casual workers or they are self-employed (small scale business) and assisted by unpaid/family worker(s). No specific maternity protection entitlements are currently available for WRA working informally in Indonesia. This study aims to estimate the financing need of providing maternity leave cash transfer (MCT) for WRA working in the informal sector in Indonesia.MethodThe costing methodology used is the adapted version of the World Bank methodology by Vilar-Compte et al, following pre-set steps to estimate costs using national secondary data. We used the 2018 Indonesian National Socio-Economic Survey to estimate the number of women working informally who gave birth within the last year. The population covered, potential cash transfer’s unitary cost, the incremental coverage of the policy in terms of time and coverage, and the administrative costs were used to estimate the cost of MCT for the informal sector.ResultAt 100% coverage for 13 weeks of leave, the yearly financing need of MCT ranged from US$175million (US$152/woman) to US$669million (US$583/woman). The share of the yearly financing need did not exceed 0.5% of Indonesian Gross Domestic Product (GDP).ConclusionsThe yearly financing need of providing MCT for eligible WRA working in the informal sector is economically attractive as it amounts to less than 0.5% of GDP nominal of Indonesia. While such a program would be perceived as a marked increase from current public health spending at the onset, such an investment could substantially contribute to the success of breastfeeding and substantial corresponding public health savings given that more than half of working Indonesian WRA are employed in the informal sector. Such policies should be further explored while taking into consideration realistic budget constraints and implementation capacity.
Applying regulatory science in traditional chinese medicines for improving public safety and facilitating innovation in China: a scoping review and regulatory implications
Authors: Liang Zuanji , Lai Yunfeng , Li Meng , Shi Junnan , Lei Chi Ieong , Hu Hao , Ung Carolina Oi Lam 
Published: February 2021

Abstract
Background
The National Medical Products Administration (NMPA) in China has set to advance the regulatory capacity of traditional Chinese medicines (TCMs) with the adoption of regulatory science (RS). However, the priority of actions at the interface of RS and TCMs were yet to be defined. This research aims to identify the priority areas and summarize core actions for advancing RS for traditional medicines in China.

Methods
A mixed approach of documentary analysis of government policies, regulations and official information about TCMs regulation in China, and a scoping review of literature using 4 databases (PubMed, ScienceDirect, Scopus and CNKI) on major concerns in TCMs regulation was employed.

Results
Ten priority areas in the development of TCM-related regulatory science in China have been identified, including: (1) modernizing the regulatory system with a holistic approach; (2) advancing the methodology for the quality control of TCMs; (3) fostering the control mechanism of TCMs manufacturing process; (4) improving clinical evaluation of TCMs and leveraging real world data; (5) re-evaluation of TCMs injection; (6) developing evaluation standards for classic TCMs formula; (7) harnessing diverse data to improve pharmacovigilance of TCMs; (8) evaluating the value of integrative medicine in clinical practice with scientific research; (9) advancing the regulatory capacity to encourage innovation in TCMs; and (10) advancing a vision of collaboration for RS development in TCMs.

Conclusions
RS for TCMs in China encompasses revolution of operational procedures, advancement in science and technology, and cross-disciplinary collaborations. Such experiences could be integrated in the communications among drug regulatory authorities to promote standardized and scientific regulation of traditional medicines.
Low expression of NSD1, NSD2, and NSD3 define a subset of human papillomavirus-positive oral squamous carcinomas with unfavorable prognosis
Authors: Gameiro Steven F. , Ghasemi Farhad , Zeng Peter Y. F. , Mundi Neil , Howlett Christopher J. , Plantinga Paul , Barrett John W. , Nichols Anthony C. , Mymryk Joe S. 
Published: February 2021

Abstract
Background
Frequent mutations in the nuclear receptor binding SET domain protein 1 (NSD1) gene have been observed in head and neck squamous cell carcinomas (HNSCC). NSD1 encodes a histone 3 lysine-36 methyltransferase. NSD1 mutations are correlated with improved clinical outcomes and increased sensitivity to platinum-based chemotherapy agents in human papillomavirus-negative (HPV-) tumors, despite weak T-cell infiltration. However, the role of NSD1 and related family members NSD2 and NSD3 in human papillomavirus-positive (HPV+) HNSCC is unclear.

Methods
Using data from over 500 HNSCC patients from The Cancer Genome Atlas (TCGA), we compared the relative level of mRNA expression of NSD1, NSD2, and NSD3 in HPV+ and HPV- HNSCC. Correlation analyses were performed between T-cell infiltration and the relative level of expression of NSD1, NSD2, and NSD3 mRNA in HPV+ and HPV- HNSCC. In addition, overall survival outcomes were compared for both the HPV+ and HPV- subsets of patients based on stratification by NSD1, NSD2, and NSD3 expression levels.

Results
Expression levels of NSD1, NSD2 or NSD3 were not correlated with altered lymphocyte infiltration in HPV+ HNSCC. More importantly, low expression of NSD1, NSD2, or NSD3 correlated with significantly reduced overall patient survival in HPV+, but not HPV- HNSCC.

Conclusion
These results starkly illustrate the contrast in molecular features between HPV+ and HPV- HNSCC tumors and suggest that NSD1, NSD2, and NSD3 expression levels should be further investigated as novel clinical metrics for improved prognostication and patient stratification in HPV+ HNSCC.
Automated detection and quantification of reverse triggering effort under mechanical ventilation
Authors: Pham Tài , Montanya Jaume , Telias Irene , Piraino Thomas , Magrans Rudys , Coudroy Rémi , Damiani L. Felipe , Mellado Artigas Ricard , Madorno Matías , Blanch Lluis , Brochard Laurent ,   the BEARDS study investigators, Pham Tài , Montanya Jaume , Telias Irene , Piraino Thomas , Magrans Rudys , Coudroy Rémi , Damiani L. Felipe , Mellado Artigas Ricard , Madorno Matías , Blanch Lluis , Brochard Laurent , Santis Cesar , Mauri Tommaso , Spinelli Elena , Grasselli Giacomo , Spadaro Savino , Volta Carlo Alberto , Mojoli Francesco , Georgopoulos Dimitris , Kondili Eumorfia , Soundoulounaki Stella , Becher Tobias , Weiler Norbert , Schaedler Dirk , Roca Oriol , Santafe Manel , Mancebo Jordi , Heunks Leo , de Vries Heder , Chen Chang-Wen , Zhou Jian-Xin , Chen Guang-Qiang , Rittayamai Nuttapol , Tiribelli Norberto , Fredes Sebastian , Mellado Artigas Ricard , Ferrando Ortolá Carlos , Beloncle François , Mercat Alain , Arnal J. M. , Diehl J. L. , Demoule A. , Dres M. , Jochmans S. , Chelly J. , Terzi Nicolas , Guérin Claude , Baedorf Kassis E. , Beitler J. , Chiumello Davide , Bolgiaghi Erica Ferrari Luca , Fanelli V. , Alphonsine J. E. , Thille Arnaud W. , Papazian Laurent 
Published: February 2021

Abstract
Background
Reverse triggering (RT) is a dyssynchrony defined by a respiratory muscle contraction following a passive mechanical insufflation. It is potentially harmful for the lung and the diaphragm, but its detection is challenging. Magnitude of effort generated by RT is currently unknown. Our objective was to validate supervised methods for automatic detection of RT using only airway pressure (Paw) and flow. A secondary objective was to describe the magnitude of the efforts generated during RT.

Methods
We developed algorithms for detection of RT using Paw and flow waveforms. Experts having Paw, flow and esophageal pressure (Pes) assessed automatic detection accuracy by comparison against visual assessment. Muscular pressure (Pmus) was measured from Pes during RT, triggered breaths and ineffective efforts.

Results
Tracings from 20 hypoxemic patients were used (mean age 65 ± 12 years, 65% male, ICU survival 75%). RT was present in 24% of the breaths ranging from 0 (patients paralyzed or in pressure support ventilation) to 93.3%. Automatic detection accuracy was 95.5%: sensitivity 83.1%, specificity 99.4%, positive predictive value 97.6%, negative predictive value 95.0% and kappa index of 0.87. Pmus of RT ranged from 1.3 to 36.8 cmH20, with a median of 8.7 cmH20. RT with breath stacking had the highest levels of Pmus, and RTs with no breath stacking were of similar magnitude than pressure support breaths.

Conclusion
An automated detection tool using airway pressure and flow can diagnose reverse triggering with excellent accuracy. RT generates a median Pmus of 9 cmH2O with important variability between and within patients.

Trial registration
BEARDS, NCT03447288.
The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis
Authors: Téblick Arno , Vander Perre Sarah , Pauwels Lies , Derde Sarah , Van Oudenhove Tim , Langouche Lies , Van den Berghe Greet 
Published: February 2021

Abstract
Background
Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ We hypothesized that sepsis acutely activates the hypothalamus to generate, via corticotropin-releasing hormone (CRH) and vasopressin (AVP), ACTH-induced hypercortisolemia. Thereafter, via increased availability of free cortisol, of which breakdown is reduced, feedback inhibition at the pituitary level interferes with normal processing of pro-opiomelanocortin (POMC) into ACTH, explaining the ACTH–cortisol dissociation. We further hypothesized that, in this constellation, POMC leaches into the circulation and can contribute to adrenocortical steroidogenesis.

Methods
In two human studies of acute (ICU admission to day 7, N = 71) and prolonged (from ICU day 7 until recovery; N = 65) sepsis-induced critical illness, POMC plasma concentrations were quantified in relation to plasma ACTH and cortisol. In a mouse study of acute (1 day), subacute (3 and 5 days) and prolonged (7 days) fluid-resuscitated, antibiotic-treated sepsis (N = 123), we further documented alterations in hypothalamic CRH and AVP, plasma and pituitary POMC and its glucocorticoid-receptor-regulated processing into ACTH, as well as adrenal cortex integrity and steroidogenesis markers.

Results
The two human studies revealed several-fold elevated plasma concentrations of the ACTH precursor POMC from the acute to the prolonged phase of sepsis and upon recovery (all p < 0.0001), coinciding with the known ACTH–cortisol dissociation. Elevated plasma POMC and ACTH–corticosterone dissociation were confirmed in the mouse model. In mice, sepsis acutely increased hypothalamic mRNA of CRH (p = 0.04) and AVP (p = 0.03) which subsequently normalized. From 3 days onward, pituitary expression of CRH receptor and AVP receptor was increased. From acute throughout prolonged sepsis, pituitary POMC mRNA was always elevated (all p < 0.05). In contrast, markers of POMC processing into ACTH and of ACTH secretion, negatively regulated by glucocorticoid receptor ligand binding, were suppressed at all time points (all p ≤ 0.05). Distorted adrenocortical structure (p < 0.05) and lipid depletion (p < 0.05) were present, while most markers of adrenocortical steroidogenic activity were increased at all time points (all p < 0.05).

Conclusion
Together, these findings suggest that increased circulating POMC, through CRH/AVP-driven POMC expression and impaired processing into ACTH, could represent a new piece in the puzzling ACTH–cortisol dissociation.
Secrecy analysis of short-packet transmissions in ultra-reliable and low-latency communications
Authors: He Jianhua , Zhao Guangheng , Wang Lu , Sun Xue , Yang Lei 
Published: February 2021

AbstractIn this paper, we investigate the secrecy performance of short-packet transmissions in ultra-reliable and low-latency communications (URLLC). We consider the scenario where a multi-antenna source communicates with a single-antenna legitimate receiver requiring ultra-high reliability and low latency, in the presence of a single-antenna eavesdropper. In order to safeguard URLLC, the source transmits the artificial noise (AN) signal together with the confidential signal to confuse the eavesdropper. We adopt a lower bound on the maximal secrecy rate as the secrecy performance metric for short-packet transmissions in URLLC, which takes the target decoding error probabilities at the legitimate receiver and the eavesdropper into account. Using this metric, we first derive a compact expression of the generalized secrecy outage probability (SOP). Then, we formally prove that the generalized SOP is a convex function with respect to the power allocation factor between the confidential signal and the AN signal. We further determine the optimal power allocation factor that minimizes the generalized SOP. The results presented in this work can be useful for designing new secure transmission schemes for URLLC.
A hybrid recommender system based-on link prediction for movie baskets analysis
Authors: Vahidi Farashah Mohammadsadegh , Etebarian Akbar , Azmi Reza , Ebrahimzadeh Dastjerdi Reza 
Published: February 2021

AbstractOver the past decade, recommendation systems have been one of the most sought after by various researchers. Basket analysis of online systems’ customers and recommending attractive products (movies) to them is very important. Providing an attractive and favorite movie to the customer will increase the sales rate and ultimately improve the system. Various methods have been proposed so far to analyze customer baskets and offer entertaining movies but each of the proposed methods has challenges, such as lack of accuracy and high error of recommendations. In this paper, a link prediction-based method is used to meet the challenges of other methods. The proposed method in this paper consists of four phases: (1) Running the CBRS that in this phase, all users are clustered using Density-based spatial clustering of applications with noise algorithm (DBScan), and classification of new users using Deep Neural Network (DNN) algorithm. (2) Collaborative Recommender System (CRS) Based on Hybrid Similarity Criterion through which similarities are calculated based on a threshold (lambda) between the new user and the users in the selected category. Similarity criteria are determined based on age, gender, and occupation. The collaborative recommender system extracts users who are the most similar to the new user. Then, the higher-rated movie services are suggested to the new user based on the adjacency matrix. (3) Running improved Friendlink algorithm on the dataset to calculate the similarity between users who are connected through the link. (4) This phase is related to the combination of collaborative recommender system’s output and improved Friendlink algorithm. The results show that the Mean Squared Error (MSE) of the proposed model has decreased respectively 8.59%, 8.67%, 8.45% and 8.15% compared to the basic models such as Naive Bayes, multi-attribute decision tree and randomized algorithm. In addition, Mean Absolute Error (MAE) of the proposed method decreased by 4.5% compared to SVD and approximately 4.4% compared to ApproSVD and Root Mean Squared Error (RMSE) of the proposed method decreased by 6.05 % compared to SVD and approximately 6.02 % compared to ApproSVD.
Clinical Characteristics and Histopathological Patterns of Hodgkin Lymphoma and Treatment Outcomes at a Tertiary Cancer Center in Ethiopia
Authors: Adam Makka , Bekueretsion Yonas , Abubeker Abdulaziz , Tadesse Fisihatsion , Kwiecinska Anna , Howe Rawleigh , Petros Beyene , Jerkeman Mats , Gebremedhin Amha 
Published: February 2021

PURPOSEIn developing countries, Hodgkin lymphoma (HL) affects the young population. In Ethiopia, nearly 70% of the population are < 35 years of age. Therefore, this study aimed to elucidate the age distribution, histopathologic patterns, clinical characteristics and treatment outcomes of HL in Ethiopia.MATERIALS AND METHODSData from clinical records of 133 consecutive patients with HL between 2014 and 2019 were reviewed and collected. Formalin-fixed paraffin-embedded tissue blocks of HL cases were collected and used for subtype classification.RESULTSA total of 68.4% (91) of the patients were male; male-to-female ratio was 2.2:1. The median age was 22 years. The age distribution was 57.1% (76), 30.8% (41), and 2.3% (3) for the age groups (10-29), (30-59), and (60-69) years, respectively. Thirteen percent (12) were associated with HIV. The majority of the cases, 50.4% (67), were of the mixed-cellularity (MCCHL) subtypes and 30% (40) nodular-sclerosis (NSCCHL). Most HIV-associated cases (60%, 6) were of the MCHL subtype. The 4-year overall survival (OS) was 83.1%. The 4-year OS of early-stage patients was 100% and advanced-stage patients with low-risk (International Prognostic Score [IPS] ≤ 2) and high-risk (IPS ≥ 3) were 94.1% and 62.9%, respectively. All patients who received combined-therapy survived, whereas those who received doxorubicin, bleomycin, vinblastine, and dacarbazine only showed a 4-year OS rate of 77.9%.CONCLUSIONHL affects the youngest and most productive population in Ethiopia. The treatment outcome is favorable in both HIV-associated and non–HIV-associated HL. However, the study population was likely a highly selected group as the majority of the Ethiopian population do not have access to specialized care.
Plasma ctDNA Response Is an Early Marker of Treatment Effect in Advanced NSCLC
Authors: Cheng Michael L. , Lau Christie J. , Milan Marina S. D. , Supplee Julianna G. , Riess Jonathan W. , Bradbury Penelope A. , Jänne Pasi A. , Oxnard Geoffrey R. , Paweletz Cloud P. 
Published: February 2021

PURPOSE Plasma circulating tumor DNA (ctDNA) analysis is routine for genotyping of advanced non–small-cell lung cancer (NSCLC); however, early response assessment using plasma ctDNA has yet to be well characterized. MATERIALS AND METHODS Patients with advanced EGFR-mutant NSCLC across three phase I NCI osimertinib combination trials were analyzed in this study, and an institutional cohort of patients with KRAS-, EGFR-, and BRAF-mutant advanced NSCLC receiving systemic treatment was used for validation. Plasma was collected before treatment initiation and serially before each cycle of therapy, and key driver mutations in ctDNA were characterized by droplet digital polymerase chain reaction. Timing of plasma versus imaging response was compared in a separate cohort of patients with EGFR-mutant NSCLC treated with osimertinib. Across cohorts, we also studied ctDNA variability before treatment start. RESULTS In the NCI cohort, 14/16 (87.5%) patients exhibited ≥ 90% decrease in mutation abundance by the first on-treatment timepoint (20-28 days from treatment start) with minimal subsequent change. Similarly, 47/56 (83.9%) patients with any decrease in the institutional cohort demonstrated ≥ 90% decrease in mutation abundance by the first follow-up draw (7-30 days from treatment start). All 16 patients in the imaging cohort with radiographic partial response showed best plasma response within one cycle, preceding best radiographic response by a median of 24 weeks (range: 3-147 weeks). Variability in ctDNA levels before treatment start was observed. CONCLUSION Plasma ctDNA response is an early phenomenon, with the majority of change detectable within the first cycle of therapy. These kinetics may offer an opportunity for early insight into treatment effect before standard imaging timepoints.