bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aldosterone Is Positively Associated With Circulating FGF23 Levels in Chronic Kidney Disease Across Four Species, and May Drive FGF23 Secretion Directly
Authors: Radloff Judith , Pagitz Maximilian , Andrukhova Olena , Oberbauer Rainer , Burgener Iwan A. , Erben Reinhold G. 
Published: April 2021

BackgroundChronic kidney disease (CKD) is accompanied by increases in circulating fibroblast growth factor 23 (FGF23) and aldosterone levels. Here, we tested the hypothesis that aldosterone may be one of the driving forces behind increased FGF23 secretion in CKD.MethodsUsing data from a prospective study in humans, a retrospective study in dogs and cats, and an experimental study in 5/6-nephrectomized mice, we analyzed the relationship between circulating FGF23 and serum aldosterone levels in CKD across four species. To assess the effects of acute inhibition of aldosterone signaling on circulating FGF23, we acutely treated mice with established CKD with the mineralocorticoid receptor blocker canrenone (50 mg/kg iv/sc), and measured intact FGF23 before and 24 h as well as 72 h after start of administration of the drug.ResultsWe found a tight positive association between circulating intact FGF23 and serum aldosterone in human, canine, and feline CKD patients, as well as in experimental murine CKD (humans: rS = 0.57, p = 0.0368; dogs: rS = 0.66, p = 0.0019; cats: rS = 0.75, p = 0.0003; mice: rS = 0.49, p = 0.0004). Injection of canrenone in mice with established CKD did not lead to changes in FGF23 levels within 24 h, but reduced FGF23 in all mice at 72 h.ConclusionAldosterone may drive enhanced FGF23 secretion in CKD, possibly explaining the tight positive association between circulating intact FGF23 and aldosterone in human, canine, and feline CKD patients as well as in experimental CKD models.
Health Control Beliefs and Attitude Toward Treatment in Psychiatric and Non-Psychiatric Clinical Samples
Authors: Pogany Laszlo , Lazary Judit 
Published: April 2021

Although there is accumulating evidence on the potential influencing factors of medication adherence, the knowledge about patients' attitudes and beliefs toward treatment is only partly utilized in adherence-improving strategies. Several internal and external factors determining adherence have been described regarding many chronic somatic diseases but in recent research, insight on psychiatric patients has been exclusively lacking. As a result, there is a scarcity of effective adherence-improving interventions. Identification of any specific differences or similarities between the attitudes toward treatment of psychiatric and non-psychiatric patients would help to support adherent behavior.We recruited 189 participants from four departments of general psychiatry (GEN PSYCH, n = 106), addictology (ADDICT, n = 42) and somatic diseases (NON PSYCH, n = 41). The Patient's Health Belief Questionnaire on Psychiatric Treatment (PHBQPT) was performed to assess the patients' attitude toward drug treatment, perceived health locus of control, and psychological reactance.The most robust difference of the PHBQT scores occurred between the GEN PSYCH and ADDICT subgroups. ADDICT patients scored significantly higher on the internal and external health locus of control and on the Psychological Reactance subscale as well. While GEN PSYCH subjects provided higher scores on the Positive Aspect of Medication compared to ADDICT persons. Interestingly, the only difference between the GEN PSYCH and NON-PSYCH groups was the more pronounced mistrust in physicians in the case of psychiatric patients.Our data suggest that mistrust toward medication does not differ in psychiatric and non-psychiatric samples, while the acceptance of the doctor's competency may be stronger in the non-psychiatric sample. The analysis of these factors provides information which could help us better understand this important issue and to develop more efficient interventions for improving adherence.
Options for Care of Elderly Inpatients With Chronic Diseases: Analysis of Distribution and Factors Influencing Use of Care in Shanghai, China
Authors: Shi Jianwei , Chen Ning , Liu Nana , Yang Yan , Yu Dehua , Jin Hua , Luo Li , Gong Xin , Liu Qian , Chen Chen , Yu Wenya , Wang Zhaoxin 
Published: April 2021

Background: China's ability to provide sufficient healthcare for an elderly population with chronic diseases has become a challenge because of poor utilization of different levels of medical institutions. We aimed to explore the characteristics and factors influencing patient choices and the resulting utilization of different levels of public medical institutions among elderly inpatients with chronic diseases.Methods: Data were collected from the Information Center of the Health and Family Planning Commission of Pudong New Area in Shanghai from 2013 to 2016. A cross-sectional study using multinomial logistic regression analysis was performed to find the factors influencing use of care. Records of patients were identified from electronic health records from public medical institutions.Results: There were 95,445 elderly inpatients with chronic diseases in public medical institutions, 17.78% in community health centers, 68.44% in secondary hospitals, and 13.78% in tertiary hospitals. Compared with those over 80 years old, the 60–69 age group showed a preference for secondary hospitals (OR = 2.980, P &lt; 0.001) and tertiary hospitals (OR = 4.497, P &lt; 0.001), a trend also observed in the 70–79 age group (OR = 1.353, P &lt; 0.001; OR = 1.673, P &lt; 0.001). Compared with those using urban employee basic medical insurance, inpatients using urban resident basic medical insurance were less likely to visit secondary hospitals than community health centers (OR = 0.237, P &lt; 0.001) or tertiary hospitals (OR = 0.293, P &lt; 0.001). Compared with those inpatients who were married, inpatients who were widowed were less likely to go to secondary hospitals (OR = 0.391, P &lt; 0.001) or tertiary hospitals (OR = 0.045, P &lt; 0.001) than community health centers.Conclusions: The utilization of different levels of medical institutions by elderly people is not well-suited to the respective functions of these medical institutions. Most care services should be provided by community health centers, but our findings indicate that elderly people are more inclined to seek inpatient care at secondary hospitals and tertiary hospitals with some variation based on the patients' sex, age, medical insurance, expenses, and expected length of stay.
Prevalence of Dental Caries and Associated Factors in East Africa, 2000–2020: Systematic Review and Meta-Analysis
Authors: Teshome Amare , Muche Abebe , Girma Biruk 
Published: April 2021

Background:Dental caries affects mastication, growth and development, and school attendance and has a long-term psychological effect on affected individuals. In developing countries, the prevalence of dental caries is increasing due to the growing consumption of sugary foods, poor tooth brushing habits, and a low level of awareness about dental caries. Even if there was a high prevalence of dental caries in sub-Saharan Africa, there is a paucity of data on the prevalence of dental caries in East Africa. Hence, this study aimed to determine the prevalence of dental caries and associated factors in East Africa.Methods:A systematic search of articles was conducted in MEDLINE, Scopus, and Google Scholar using all the synonyms of dental caries in published literature (until December 2020) in East Africa. Important data were extracted using a standardized data extraction form prepared in Excel. Stata software (version 14.0) was used to calculate the pooled prevalence of dental caries. Besides, subgroup analysis was done based on country and dentition type. Moreover, associated factors of dental caries were assessed and the overall effect was presented in the form of odds ratios. The quality of the included studies was evaluated using the Joanna Briggs Institute reviewers' manual.Results:The overall pooled prevalence of dental caries was found to be 45.7% (95% CI = 38.0–53.4). The pooled prevalence was high in Eritrea (65.2%, 95% CI = 49.2–81.1), followed by Sudan (57.8%, 95% CI = 36.0–79.7), and a low prevalence was found in Tanzania (30.7%, 95% CI = 21.5–39.9). Moreover, the subgroup analysis revealed a prevalence of 50% (95% CI = 38.4–62.1) in permanent dentition and 41.3% (95% CI = 33.5–49.2) in mixed dentition. The overall mean decayed, missed, and filled permanent (DMFT) and primary (dmft) teeth were 1.941 (95% CI = 1.561–2.322) and 2.237 (95% CI = 1.293–3.181), respectively. High DMFT scores were reported in Sudan (3.146, 95% CI = 1.050–5.242) and Uganda (2.876, 95% CI = 2.186–3.565). Being female (OR = 1.34, 95% CI = 1.24–1.46) and having poor tooth brushing habit (OR = 1.967, 95% CI = 1.67–2.33) were independent risk factors of dental caries.Conclusion:The overall prevalence of dental caries was comparatively high. Being female and poor oral health practice were independent risk factors of dental caries. The Ministry of Health of the member countries, along with dental associations of each country, ought to offer due attention to strengthen the oral health program in schools and primary health care centers and the implementation of school water fluoridation.
Propuesta de estrategia académica basada en la deontología profesional para fortalecer las competencias axiológicas
Authors: Ortiz Yerardo , Vargas Deivid , Velásquez Luisedgar 
Published: April 2021

La presente investigación surgió en vista de la necesidad de incorporar en el pensum de estudios de la carrera de Contaduría Pública de la Facultad de Ciencias Económicas y Sociales de la Universidad de Carabobo, una materia sobre Deontología Profesional, con el fin de formar a los estudiantes de manera integral con sólidos conocimientos y valores para afrontar el campo de trabajo con profesionalidad. Se planteó como objetivo primordial diseñar una estrategia académica para fortalecer el dominio de conocimiento en Deontología Profesional a los estudiantes de Contaduría Pública de la Universidad de Carabobo. La investigación asumió el enfoque cuantitativo, enmarcado en un diseño de campo y carácter descriptivo, apoyada con referencias bibliográficas-documentales. Como población objetivo, se enfocó en los estudiantes del décimo semestre de Contaduría Pública de la FACES-UC. A partir de ello se pudo concluir que la mayoría de los estudiantes de la carrera de Contaduría Pública de la FACES - Universidad de Carabobo no manejan ni conocen que es la deontología profesional, así como los códigos deontológicos y su importancia dentro del ejercicio profesional de la Contaduría Pública, lo cual lo limita en la realización de un ejercicio responsable, justo y honesto.
ABSTRACT
This research arose in view of the need to incorporate in the curriculum of the Public Accounting career of the Faculty of Economic and Social Sciences of the University of Carabobo, a subject on Professional Deontology, in order to train students comprehensively with solid knowledge and values to face the field of work with professionalism. The main objective was to design an academic strategy to strengthen the domain of knowledge in Professional Deontology for students of Public Accounting at the University of Carabobo. The research assumed the quantitative approach, framed in a field design and descriptive character, supported by bibliographic-documentary references. As a target population, it focused on students in the tenth semester of Public Accounting at FACES-UC. From this, it was possible to conclude that most of the students of the Public Accounting career at FACES - University of Carabobo do not handle or know what professional deontology is, as well as the deontological codes and their importance within the professional practice of the Public Accounting, which limits it in carrying.
An investigation of the effects of melatonin administration on biochemical parameters in rats with experimental cartilage damage
Authors: Yıldız Kadri , Tahiroğlu Veysel , Boy Fatih , Koç Seher , Yıldız Vahit , Demirel Esra 
Published: April 2021

Objective: This study was intended to show the effects of melatonin (MEL) in the treatment of cartilage damage in a rat model as a novel field of application.
Materials and Methods: Male Sprague Dawley rats aged 3-4 months were assigned into four groups of six rats each. Group I represented the sham group. In groups 2, 3, and 4, the right knee medial meniscus was surgically destabilized. MEL was administered to groups 3 and 4 twice a week at dosages of 0.4 μg/ml and 4 μg/ml, respectively. The application continued for four weeks. Histological examinations, imaging studies [computed tomography and magnetic resonance imaging], and biochemical tests [cartilage and bone turnover markers (COMP and CTX-I)] were performed.
Results: The application of MEL initiated regeneration in the damaged areas. However, cartilage repair was not observed in areas with experimental cartilage damage without MEL application. MEL-treated rats had higher T2 scores compared to Group 1 in the median femoral condyle at the 12th week (p<0.05). Serum COMP and CTX-I levels at 12 weeks were significantly higher in Group 2 compared to Group 1 (p<0.05). Serum COMP and CTX-I levels at 12 weeks were lower in groups 3 and 4, but were also significantly higher than in Group 1 (p<0.05).
Conclusion: We recommend MEL therapy for diseases related to cartilage damage. MEL seems to exert its therapeutic effect on cartilage damage through its antioxidant properties.
Relationship Between Husband’s Support And Mother’s Attitude To Exclusive Breastfeeding For 6 Months
Authors: Indana Zulfa Fariza , Sutrisminah Emi , Rahmawati K. Meilia 
Published: April 2021

Introduction: Breastfeeding is the responsibility of a woman who has a baby. The decision of the Indonesian Ministry of Health assign exclusive breastfeeding was given for 6 months and continues until 2 years old. Until now in Indonesia there are still many women who have not given exclusive breastfeeding to their babies. The failure to give exclusive breastfeeding is caused by several factors, one of which is the husband's support and mother's attitude. Objective: To determine the relationship between husband's support and the mother's attitude to breastfeed exclusively for 6 months in the Kudu Village, Semarang City. Methods: This was a descriptive qualitative study with an analytical study design with Cross Sectional. The study populations was 116 pregnant womens, the research sample was 32 third trimester pregnant womens. The sampling technique in this study uses total sampling. Results: Fisher's Exact Test analysis results on the two variables of this study obtained p value = 0.018 where p value <0.05 then Ha is accepted, which means there is a relationship between the husband's support variable and the mother's attitude to breastfeed exclusively for 6 months. Conclusion: The mayority of respondents recived husband’s support and had a good attitude for exclusive breastfeeding for 6 months.
Effect Of Bioinsecticide Granule Mixture Of Sugar Apple Seed (Annonae Squamosa) And Betel Leaf (Piper Betle) On Morphology Of Eggs Aedes Aegypti
Authors: Novitasari Firdha , Wahyuni Dwi , Sulistyaningsih Erma 
Published: April 2021

Introduction: Dengue hemorrhagic fever (DHF) is an important public health problem in Indonesia because its morbidity and mortality are quite high. Prevention by vector control methods with chemical insecticides adversely affects the environment. Research on granular bioinsectide mixture of betel leaf extract and sugar apple seeds against Aedes aegypti is expected to be used to break the chain of Aedes aegypti mosquitoes starting from the juvenile stage (eggs) as an effort to control the vector population naturally. Objective: This study aims to analyze the effect of granule bioinsecticide mixture of sugar apple seed extract and betel leaf on changes in the morphology of Aedes aegypti eggs. Methods: This study is a true-experimental study with a Post test Only Control Group Design design. The treatment group will be given a granular bioinsecticide, a mixture of sugar apple seed extract and betel leaf, positive control will be given abate while negative control will be given aquades. Each group uses 25 eggs with 3 repetitions. On day 3, all eggs will be observed using a stereo microscope to determine morphological changes. The data obtained will be analyzed using ordinal regression test. Results: the ordinal regression test got the value of ρ in the Wald test between (0.012 - 0.955)> α = 0.01. Conclusion: there is no effect of mixed granules of betel leaf and sugar apple seeds on the mortality of Aedes aegypti eggs. Further research is needed on new formulations using other natural ingredients to increase the effect of ovicides on Aedes aegypti.
Descriptive Study Of Factors Affecting Nurses Caring Behavior In Baladhika Husada Jember Hospital
Authors: Efrizal amrullah Akhmad , Elliya Astutik Emi , Djalil Ahbab Achmad 
Published: April 2021

Introduction: Caring behavior is very important for nurses to have because it illustrates the quality of nursing care, especially for nurses who work in inpatient units. There are three factors that can influence the level of caring behavior, namely individual, psychological and organizational factors. Meanwhile, caring behavior is assessed from Knowing, Being With, Doing For, Enabling, and Maintaining Belief. Objective: To describe the factors that influence the caring behavior of nurses in Baladhika Husada Jember Hospital. Methods: Nonexperimental design with descriptive type, in which the approach was cross sectional, carried out for 1 month and involved 62 respondents. Results: 47 respondents stated that the three factors above had an influence on caring behavior and 15 respondents stated that it had no effect, while the caring behavior of respondents in the good category was 58 people and 4 people were not good. Analysis of data using the One-Sample Binominal test at alpha (α) = 0.05, has the p-value = 0.000, which illustrates the difference between the factors that influence caring behavior towards nurses caring behavior. Conclusion: The factors that influence caring behavior are directly proportional to caring behavior, meaning the better factors that influence caring behavior, the better nurses caring behavior level. Maintaining and improving caring behavior requires good effort and cooperation between the hospital manager which is the place for health services and nurses as nursing care providers.
Building Canvas Strategy for Integrated Tourism Area and Benchmark: Blue Ocean Strategy Approach
Authors: Utami Christina Whidya , Susanto Hendro , Septina Fanny , Pujirahayu Yoseva Maria , Razak Muhammad Nurdin 
Published: April 2021

This research aims to identify tourism factors that should be eliminate, reduce, raise, and create (ERRC) to indicate the characteristics of Blue Ocean Strategy (BOS) in order to revitalize the development of Kenjeran tourism area, Surabaya by taking into account aspects of education, local economic improvement, and environmental conservation. The research methodology is based on descriptive approach through analyzing the strength, weakness, opportunities, and threats (SWOT) to find the key success factor, the industry benchmarks, and the tourism market agents in order to understand the ERRC and to set a canvas strategy. The result shows that Revitalization is done by; Eliminating Aspect of Sustainable Environment including environmental pollution, abrasion, and unregulated zone. Reducing Aspect of Attractions, including: a shift in local culture and focus on shopping area. Factors that should be raise is Aspect of Accessibility and Empowerment, including: tourism facilities, and community capacity development. whereasWhereas elements that should be created are included in Aspect of Tourism Industry, including pattern of partnership and community development. The novelties of this research is using Blue Ocean Strategy via a 4-step approach: Eliminate, Reduce, Raise, and Create (ERRC) to revitalize an integrated tourist area.
Keywords: Eliminate; Reduce; Raise and Create (ERRC); canvas strategy; Blue Ocean Strategy.
Broken into Pieces: ATLAS and Aliqa Uma as One Single Stream
Authors: Li Ting S. , Koposov Sergey E. , Erkal Denis , Ji Alexander P. , Shipp Nora , Pace Andrew B. , Hilmi Tariq , Kuehn Kyler , Lewis Geraint F. , Mackey Dougal , Simpson Jeffrey D. , Wan Zhen , Zucker Daniel B. , Bland-Hawthorn Joss , Cullinane Lara R. , Da Costa Gary S. , Drlica-Wagner Alex , Hattori Kohei , Martell Sarah L. , Sharma Sanjib ,   (S5 Collaboration)
Published: April 2021

Abstract
We present the first spectroscopic measurements of the ATLAS and Aliqa Uma streams from the Southern Stellar Stream Spectroscopic Survey (S
5), in combination with the photometric data from the Dark Energy Survey and astrometric data from Gaia. From the coherence of spectroscopic members in radial velocity and proper motion, we find that these two systems are extremely likely to be one stream with discontinuity in morphology and density on the sky (the “kink” feature). We refer to this entire stream as the ATLAS-Aliqa Uma stream, or the AAU stream. We perform a comprehensive exploration of the effect of baryonic substructures and find that only an encounter with the Sagittarius dwarf ∼0.5 Gyr ago can create a feature similar to the observed “kink.” In addition, we also identify two gaps in the ATLAS component associated with the broadening in the stream width (the “broadening” feature). These gaps have likely been created by small mass perturbers, such as dark matter halos, as the AAU stream is the most distant cold stream known with severe variations in both the stream surface density and the stream track on the sky. With the stream track, stream distance, and kinematic information, we determine the orbit of the AAU stream and find that it has been affected by the Large Magellanic Cloud, resulting in a misalignment between the proper motion and stream track. Together with the Orphan-Chenab Stream, AAU is the second stream pair that has been found to be a single stream separated into two segments by external perturbation.
Revealing Gravitational Collapse in the Serpens G3–G6 Molecular Cloud Using Velocity Gradients
Authors: Hu Yue , Lazarian A. , Stanimirović Snežana 
Published: April 2021

Abstract
The relative role of turbulence, magnetic fields, and self-gravity in star formation is a subject of intensive debate. We present IRAM 30 m telescope observations of the 13CO (1–0) emission in the Serpens G3–G6 molecular cloud and apply to the data a set of statistical methods. These include the probability density functions of column density and the velocity gradients technique. We combine our data with the Planck 353 GHz polarized dust emission observations and Hershel H2 column density. We suggest that the Serpens G3–G6 south clump is undergoing a gravitational collapse. Our analysis reveals that the gravitational collapse happens at volume density n ≥ 103 cm−3. We estimate the plane-of-the-sky magnetic field strength to be approximately 120 μG using the traditional Davis–Chandrasekhar–Fermi method and 100 μG using a new technique proposed in Lazarian et al (2020). We find that the Serpens G3–G6 south clump’s total magnetic field energy significantly surpasses kinetic energy and gravitational energy. We conclude that the gravitational collapse could be successfully triggered in a supersonic and sub-Alfvénic cloud.