bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between different ventricular rate control levels and cardiac remodeling in early persistent atrial fibrillation: a prospective cohort study
Authors: Liu Yongrong , Liu Jun , Wang Dan 
Published: January 2025

BackgroundAtrial fibrillation (AF) is a prevalent cardiac arrhythmia, with ventricular rate control being a critical therapeutic target. However, the optimal range for ventricular rate control remains unclear. Additionally, the relationship between different levels of ventricular rate control and cardiac remodeling in patients with atrial fibrillation remains unclear.ObjectiveThis study aims to explore the relationship between different levels of heart rate control and cardiac remodeling in patients with early persistent atrial fibrillation.MethodsA bi-center prospective cohort study was conducted, enrolling patients with newly diagnosed persistent AF and rapid ventricular rates, yet with a normal cardiac size, from March 2019–May 2020 at the people's hospital of Chongqing Hechuan and the First Affiliated Hospital of Zhengzhou University. Patients were divided into four groups based on their average ventricular rate levels from 24 h Holter monitoring: Group I (40 ≤ average rate &lt; 60 bpm), Group II (60 ≤ average rate &lt;80 bpm), Group III (80 ≤ average rate &lt; 100 bpm), and Group IV (average rate ≥ 100 bpm).The study tracked changes in left atrial diameter (LAD), left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF), and the severity of mitral regurgitation over one year.ResultsA total of 764 patients were enrolled. We found that there were no significant differences in cardiac remodeling among the groups of patients before the observation. However, after one-year follow-up observation, there were significant differences in the degree of cardiac remodeling among the groups (p &lt; 0.001). Specifically, the severity of cardiac remodeling, including LVEDD, LAD, LVEF, and mitral regurgitation, showed the following trend: Group II &lt; Group I &lt; Group III &lt; Group IV. Further regression analysis indicated that body mass index (BMI) might be related to changes in LAD. Additionally, the use of digoxin could affect changes in left ventricular ejection fraction. At the same time, the use of diltiazem, bisoprolol, as well as factors like hypertension, coronary artery disease, smoking, diabetes, and chronic obstructive pulmonary disease, might be closely associated with the worsening of mitral regurgitation.ConclusionThis study shows that in early persistent AF patients, different levels of heart rate control are related to varying degrees of cardiac remodeling. These results suggest that maintaining an average ventricular rate within the range of 60–80 beats per minute may be associated with milder cardiac remodeling. On the other hand, an average heart rate greater than 100 bpm appears to be associated with the most severe cardiac remodeling.Registration NumberChiCTR2400079978; Registered 17 January 2024–Retrospectively registered: https://www.chictr.org.cn/showproj.html?proj=198684.
Fractal Continuum Maxwell Creep Model
Authors: Kryvko Andriy , Gutiérrez-Torres Claudia del C. , Jiménez-Bernal José Alfredo , Susarrey-Huerta Orlando , Reyes de Luna Eduardo , Samayoa Didier 
Published: January 2025

In this work, the fractal continuum Maxwell law for the creep phenomenon is introduced. By mapping standard integer space-time into fractal continuum space-time using the well-known Balankin’s approach to variable-order fractal calculus, the fractal version of Maxwell model is developed. This methodology employs local fractional differential operators on discontinuous properties of fractal sets embedded in the integer space-time so that they behave as analytic envelopes of non-analytic functions in the fractal continuum space-time. Then, creep strain ε(t), creep modulus J(t), and relaxation compliance G(t) in materials with fractal linear viscoelasticity can be described by their generalized forms, εβ(t),Jβ(t) and Gβ(t), where β=dimS/dimH represents the time fractal dimension, and it implies the variable-order of fractality of the self-similar domain under study, which are dimS and dimH for their spectral and Hausdorff dimensions, respectively. The creep behavior depends on beta, which is characterized by its geometry and fractal topology: as beta approaches one, the fractal creep behavior approaches its standard behavior. To illustrate some physical implications of the suggested fractal Maxwell creep model, graphs that showcase the specific details and outcomes of our results are included in this study.
Evaluation of Colon Capsule Utilisation in Europe—CAPTURE EU Survey Findings
Authors: Lei Ian Io , Robertson Alexander , Koulaouzidis Anastasios , Arasaradnam Ramesh , the international Capsule Endoscopy Research (iCARE) Group  
Published: January 2025

Background/Objectives: Colon capsule endoscopy (CCE) is a non-invasive method for visualising the colon, but its clinical adoption has been slow. Although the COVID-19 pandemic reignited interest in CCE, its role in conventional gastrointestinal investigations remains unclear, leading to varied practices across Europe. This highlights the need for a comprehensive understanding of diverse approaches to CCE in clinical practice. Method: A web-based survey was conducted from January to July 2024, targeting European gastroenterologists and colorectal surgeons interested in capsule endoscopy through the International Capsule Endoscopy Research (iCARE) Group. The survey aimed to understand CCE application across Europe and investigate factors influencing its uptake. Results: Thirty-eight (n = 38) valid responses were received from 19 European countries. While 88% reported access to CCE, only 45% had local services readily available, and just 7% included CCE in national guidelines. The most common indication for CCE was for patients who declined or could not tolerate colonoscopy (30%), with 77% of CE specialists preferring its use in fit patients. Ease of access was significantly associated with service availability (p = 0.0358). Barriers to uptake included lack of reimbursement, insufficient knowledge, and limited use in research settings. Only 27% of specialists viewed CCE positively, while 57% had a negative perception. Conclusions: This study reveals the wide variation in CCE practices and critical factors influencing its uptake. Understanding common indications and patient groups is the key to guiding its future development, particularly as AI and telemedicine enhance its potential for rapid full digestive tract visualisation.
OPTIMASI BIAYA UPAH TENAGA KERJA PEMBESIAN DENGAN METODE SIMPLEKS PADA PEKERJAAN BETON BERTULANG STRUKTUR ATAS
Authors: Nurasiyah Siti , Nurdiyansyah Irsan , Sekaryadi Yudi , Natawidjana Rochany 
Published: January 2025

Kebutuhan tenaga kerja yang terampil, serta memiliki produktivitas yang tinggi sangat diperlukan saat proyek dilaksanakan. Hal ini akan mempengaruhi berjalannya proyek tersebut sehingga perlu analisis sebelum proyek konstruksi dimulai, agar mendapatkan jumlah tenaga kerja yang efisien diperlukan alokasi jumlah tenaga kerja agar tidak meningkatnya biaya yang dikeluarkan. Metode simpleks merupakan salah satu model umum dalam teknik pemrograman linier yang dapat digunakan untuk pemecahan masalah dalam mengalokasikan sumber-sumber daya yang terbatas secara optimal untuk mencapai hasil yang optimal. Tujuan penelitian ini adalah mengetahui biaya upah pekerjaan pembesian berdasarkan Analisa Harga Satuan Pekerjaan (AHSP) di lapangan dan biaya upah optimum menggunakan metoda simpleks serta mengetahui besar perbedaan biaya upah berdasarkan AHSP dan analisa modern. Penelitian ini dilakukan pada proyek pembangunan Gedung FPTK COE PPPG (CWP-01). Penelitian ini menggunakan metode kualitatif dan kuantitatif. Penelitian ini menggunakan program LiPS untuk perhitungan metode simpleks. Dari hasil penelitian ini, besar biaya upah pekerjaan pembesian berdasakan AHSP adalah sebesar Rp1.059.919.927. Optimasi biaya upah pekerjaan pembesian dengan metode simpleks menghasilkan selisih biaya RAB upah pekerjaan pembesian adalah sebesar Rp75.250.000 (6%). Dalam Analisa modern perbedaan diameter, dimensi, dan kerumitan pembesian diakomodir dengan produktivitas yang berbeda-beda, sehingga dilakukan analisa dengan hasil koefisien terendah yaitu Rp447.609.278 dan koefisien tertinggi Rp777.551.352. Optimasi biaya upah dengan metode simpleks menggunakan analisa modern didapatkan hasil sebesar Rp27.860.000 (4%) untuk koefisien terendah dan Rp64.050.000 (6%) untuk koefisien tertinggi.Kata Kunci:AHSP, Optimal, Analisa Modern, Metode Simpleks
Penyuluhan Keamanan Pangan dan Pendampingan Sertifikasi Halal Gratis (SEHATI) pada UMK Susu Kambing Amaq Farm Desa Penujak
Authors: Kurnia Nova , Utami Septiana Dwi , Rohmatillah Laila Mardiana , Rohmatillah Ismail Efendi : , Purwati Duwi , Marjan Marjan , Ariansyah Ariansyah , Aptini Mipa , Soma Raden Arya 
Published: January 2025

Keamanan pangan menjadi syarat utama dalam mengkonsumsi produk pangan. Selain itu yang lebih utama adalah terjaminnya kehalalan produk. UMK Amaq Farm yang memproduksi susu kambing perah belum memiliki pengetahuan yang memadai terkait praktik hygiene dan sertifikasi halal produknya. Kegiatan ini bertujuan untuk memberikan: 1) penyuluhan praktik baik keamanan pangan produksi susu kambing perah; dan 2) pendampingan sertifikasi halal gratis (SEHATI) melalui skema self declare. Metode pelaksanaan menggunakan metode kombinasi Participatory Rapid Appraisal (PRA) dan Participatory Learning and Action (PLA). Tahapan kegiatan antara lain analisis kebutuhan, analisis dan perencanaan, penyuluhan dan pendampingan, dan evaluasi. Hasil pengabdian ini menunjukkan 1) UMK Amaq Farm telah mampu melakukan praktik baik keamanan pangan setelah diberikan penyuluhan; dan 2) UMK Amaq Farm telah memperoleh sertifikasi halal atas produk susu kambing perahnya melalui skema self declare dengan nomor ID52110009293610823. Diharapkan setelah kegiatan pendampingan keamanan pangan dan terbitnya sertifikat halal ini, produk susu kambing UMK Amaq Farm jangkauan pemasarannya semakin luas.
Food Safety Counseling and Free Halal Certification Assistance (SEHATI) at Amaq Farm Goat Milk MSEs in Penujak Village
Abstract
Food safety is the key requirement when consuming food. More importantly, the product must be guaranteed halal. Amaq Farm Micro Small Enterprise (MSEs) producing goat milk do not have sufficient knowledge about hygiene practices and halal certification of their products. This program aims to provide: 1) advice on good handling practices for goat milk production; and 2) support for free halal certification (SEHATI) through a self-declare scheme. The implementation methodology combines Participatory Rapid Appraisal (PRA) and Participatory Learning and Action (PLA) methods. The stages of activity include needs assessment, analysis and planning, guidance and mentoring, and evaluation. The results of this service showed that 1) Amaq Farm MSEs were able to implement good food safety practices after being advised, and 2) Amaq Farm MSEs obtained Halal certification for their goat milk dairy products through a self-declaration scheme with the number ID52110009293610823. It is expected that the Amaq Farm MSEs' goat milk products will have a wider marketing reach following the food safety assistance activities and the issuance of halal certificates.
Effect of Online Frontliner Interpersonal Communication on Consumer Purchase Decisions of Cv Borneo Store Banjarmasin
Authors: Putri Pahira Recka , Lieta Dwi Novianti  , Dewi Merdayanty  
Published: January 2025

The existence of frontliners has a very viral role in providing services to consumers, because they are the first people faced by consumers when interacting with companies. As a company representative, frontliners function to create a positive first impression through the attitude and service provided. The quality of service shown by the frontliner will greatly affect consumers' perception of the company, which can ultimately affect their purchasing decisions. Therefore, good interpersonal communication from the frontliner is key in creating a satisfying customer experience. This study aims to determine the influence of online frontliner interpersonal communication on purchase decisions in CVs. Borneo Store Banjarmasin. The research method used is a quantitative approach with data collection through questionnaires distributed to consumers who shop at CV. Borneo Store. The research sample is 73 people who are randomly selected using the *simple random sampling* technique. The collected data was then analyzed using a simple linear regression with reference to the AIDDA (Attention, Interest, Desire, Decision, Action) theory, which describes the stages in the consumer decision-making process. The results of the study show that good interpersonal communication from online frontliners has a significant effect on consumer purchase decisions. A simple linear regression test showed that the determination coefficient was 40.1% with a significance level of 0.001 (<0.05), which means that online frontliner interpersonal communication had a considerable influence on the purchase decision. These findings show that effective communication between frontliners and consumers, both in-person and online, is important for building relationships, creating trust, and driving purchasing decisions. Companies need to pay attention to the quality of frontliner communication, especially in the digital era, to increase customer satisfaction and loyalty.
Keywords: Online Frontliner, Consumer, Purchase Decision, AIDDA Theory, Simple Linear Regression, Interpersonal Communication
Impact Of Green Finance On Market Value And Reputation Of Financial Service Companies
Authors: Endah Dewi Purnamasari  , Shafiera Lazuarni  , Nova Yanti Maleha  
Published: January 2025

This study aims to analyze the impact of green finance implementation, including green bonds and green loans, on the market value and reputation of financial service companies in Indonesia. The research employs a quantitative approach with an explanatory research design. Secondary data, including financial reports, sustainability reports, and ESG scores, were obtained from financial service companies listed on the Indonesia Stock Exchange (IDX) during the 2015–2025 period. The sample consists of 70 companies selected using purposive sampling. The regression analysis results indicate that green bonds and green loans have a positive and significant impact on both market value and company reputation. Green loans show a greater effect compared to green bonds on both dependent variables, reflecting their flexibility and more direct influence on corporate sustainability. The model demonstrates that green finance accounts for 65% of the variation in market value and 70% of the variation in company reputation.This study confirms that green finance not only supports global sustainability goals but also offers significant benefits to financial service companies by enhancing their competitiveness and market image. Policy implications and strategies to promote the adoption of green finance in Indonesia are also discussed.
Keywords: Green Finance,Market Value, Reputation
Need Analysis of Gamification-Based E-Learning Development with ADDIE Method for Student Learning Using Moodle Platform
Authors: Priadi Yohanes , Yosua Arda Kurnia  , Benedictus Pascal Sanjaya  
Published: January 2025

A major challenge in e-learning is maintaining student motivation and engagement in the learning process. Gamification has been proven to be an effective approach in increasing student motivation by adding game elements into the learning experience. This research aims to analyze the needs of gamification-based e-learning development for student learning using ADDIE (Analysis, Design, Development, Implementation and Evaluation) method on Moodle platform. Moodle was chosen because it supports various gamification plugins, such as Level Up XP, Block Game, Ludic, Quizventure, Game and Badge Ladder. Through a comprehensive needs analysis, this research produces an appropriate design to improve learning engagement and effectiveness. The results of this research are expected to provide guidance for the development of gamification-based e-learning that is optimal for student learning.
PENERAPAN MODEL PEMBELAJARAN PICTURE AND PICTURE DALAM MENINGKATKAN HASIL BELAJAR BIOLOGI MAHASISWA SEMESTER 1 PROGRAM STUDI PENDIDIKAN FISIKA UNIVERSITAS FLORES
Authors: Daud Maimunah Haji , Kaleka Melkyanus Bili Umbu 
Published: January 2025

Penelitian ini bertujuan untuk meningkatkan hasil belajar mahasiswa pendidikan fisika materi sistem organ pada mata kuliah biologi umum dengan menerapkan model pembelajaran picture and picture. Penelitian deskriptif kuantitatif ini menggunakan one group pretest-postest design. Penelitian ini dilakukan pada bulan September sampai November 2024. Populasi dalam penelitian ini adalah seluruh mahasiswa di program studi pendidikan fisika universitas flores, sedangkan sampel penelitian mahasiswa semester satu tahun akademik 2024/2025 yang ditentukan menggunakan teknik purposive sampling. Teknik pengumpulan data menggunakan teknik tes. Analisis data untuk hasil belajar menggunakan rumus statistik sederhana. Besarnya peningkatan atau gain score hasil belajar dianalisis dengan rumus Hake. Hasil penelitian menunjukan penerapan model pembelajaran picture and picture mampu meningkatkan hasil belajar. Hasil belajar mahasiswa setelah mengikuti pembelajaran dengan menerapkan model picture and picture termasuk katergori tinggi. Hal ini menunjukan bahwa penerapan model pembelajaran picture and picture dapat meningkatkan hasil belajar mahasiswa pada materi sistem organ.
Influence of Financial Factors on Profit Growth with Company Size as a Moderating Variable: Study of LQ45 Manufacturing Companies
Authors: Fairuz Amalia Salma , Tundjung Herlin 
Published: January 2025

The aim of this research is to determine the effect Return On Asset (ROA), Net profit Margin (NPM), Current Ratio (CR) on profit growth. And to find out whether company size as a moderating variable can strengthen ROA, NPM and CR on profit growth. This research is quantitative descriptive research using Eviews 12 software. The population in this research is manufacturing companies which are members of the LQ45 index during the research period, namely 2018-2022, totaling 18 companies. Sample selection using purposive sampling and obtained 12 companies that would become research samples. The research results show that variables Return On Asset (ROA), Net profit Margin (NPM), Current Ratio (CR) has a significant positive effect on profit growth. Meanwhile, company size chosen as a moderating variable can strengthen the positive influence of ROA, NPM and CR on profit growth.
Fire and Ice in the Whirlpool: Spatially Resolved Scaling Relations between X-Ray-emitting Hot Gas and Cold Molecular Gas in M51
Authors: Zhang Chunyi , Wang Junfeng , Cao Tian-Wen 
Published: January 2025

Abstract
The cold and hot interstellar medium in star-forming galaxies resembles the reservoir for star formation and associated heating by stellar winds and explosions during stellar evolution, respectively. We utilize data from deep Chandra observations and archival millimeter surveys to study the interconnection between these two phases and the relation to star formation activities in M51 on kiloparsec scales. A sharp radial decrease is present in the hot gas surface brightness profile within the inner 2 kpc of M51. The ratio between the total infrared luminosity (L
IR) and the hot gas luminosity (

L

0.5
−
2

keV

gas

) shows a positive correlation with the galactic radius in the central region. For the entire galaxy, a twofold correlation is revealed in the

L

0.5
−
2

keV

gas

–L
IR diagram, where

L

0.5
−
2

keV

gas

sharply increases with L
IR in the center but varies more slowly in the disk. The best fit gives a steep relation of

log
(

L

0.5
−
2

keV

gas

/

erg

s

−
1

)
=
1.82

log
(

L

IR

/

L

⊙

)
+
22.26

for the center of M51. The similar twofold correlations are also found in the

L

0.5
−
2

keV

gas

–molecular line luminosity (

L

gas

′

) relations for the four molecular emission lines CO(1–0), CO(2–1), HCN(1–0), and HCO+(1–0). We demonstrate that the core-collapse supernovae (SNe) are the primary source of energy for heating gas in the galactic center of M51, leading to the observed steep

L

0.5
−
2

keV

gas

–L
IR and

L

0.5
−
2

keV

gas

–

L

gas

′

relations, as their X-ray radiation efficiencies (η ≡

L

0.5
−
2

keV

gas

/

E

̇

SN

) increase with the star formation rate surface densities (ΣSFR), where

E

̇

SN

is the SN mechanical energy input rate.
Description of five new species from southern China, with note on the type species of Latouchia Pocock, 1901 (Araneae, Halonoproctidae)
Authors: Hao Long , Yu Kun , Zhang Feng 
Published: January 2025

The genus Latouchia Pocock, 1901 previously included 25 known species and one subspecies from Asia, 12 species and one subspecies were reported in China.
Five new species of Latouchia Pocock, 1901 from southern China are described: L. calcicola sp. nov. (♂♀) from Hainan, L. jinyun sp. nov. (♂♀) from Chongqing, L. linmufu sp. nov. (♂♀) from Hunan, L. wenchuan sp. nov. (♂) from Sichuan and L. yaoi sp. nov. (♂♀) from south part of Shaanxi. DNA barcodes of the new species described herein are provided. The potential error in the previous illustrations of the alleged male of L. fossoria Pocock, 1901 (type species of the genus) is pointed out.
Assessment of programmed cell death 1 and its programmed cell death ligand 1 levels in vitiligo
Authors: Nada Hanan R. , Mourad Ahmed , Rashed Laila A. , El-Hanafy Ghada M. , Abdallah Nermeen M.A. , Abdelhady Mohamed M. 
Published: January 2025

Background
Programmed cell death 1 (PD-1) is a cell surface protein that serves as an immune checkpoint in conjunction with its two ligands, PD-L1 and PD-L2. Recently, there has been a lot of interest in the role of the PD-1/PD-L1 pathway in immunoregulation.

Objective
To assess both PD-1 and PD-L1 levels in vitiligo patients’ marginal and nonlesional biopsies compared with normal controls and to correlate them with disease parameters.

Patients and methods
A total of 30 vitiliginous patients and 30 age and sex-matched controls were included. Full history and clinical examination were done and ELISA measured tissue levels of PD-1 and PD-L1 from lesional and nonlesional biopsies.

Results
Levels of tissue PD-1 in marginal biopsies (mean 7.89±2.48 ng/mg) were significantly higher than in nonlesional biopsies (mean 3.65±1.11 ng/mg; P<0.001) and significantly higher than the control PD-l level (mean 1.47±0.499 ng/mg; P<0.001). Nonlesional PD-1 level was also significantly higher than the control PD-l level (P<0.001). A statistically significant positive correlation was found between marginal and nonlesional PD-1 levels; (rho=0.792, P<0.001). Levels of tissue PD-L1 in marginal biopsies (mean 115±7.86 pg/mg) were significantly lower than in nonlesional skin (mean 194±8.12 pg/mg; P<0.001), and significantly lower than in controls (mean 283±27.8 pg/mg; P<0.001). Nonlesional PD-L1 level was also significantly lower than the control PD-Ll level (P<0.001).

Conclusion
Our results suggest that the PD-1/PD-L1 checkpoint seems to be implicated in the loss of peripheral tolerance in human vitiligo, with PD-1 being highly expressed, yet insufficiently stimulated due to lack of local PD-L1 expression. Since PD1 plays an important role, its agonists may have therapeutic implications in vitiligo and other autoimmune diseases but need wider-scale studies before clinical implementation.