bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Platelet, White Blood Cell Count, Platelet To White Blood Cell Ratio and Sarcopenia in Community-Dwelling Older Adults: Focus On Bushehr Elderly Health (BEH) Program
Authors: Gholizade Mohamad , Farhadi Akram , Marzban Maryam , Mahmudpour Mehdi , Nabipour Iraj , Kalantarhormozi Mohammadreza , Shafiee Gita , Ostovar Afshin , Larijani Bagher , Darabi Amir Hossein , Safavi Eisa 
Published: September 2021

Abstract
Background
Sarcopenia is a progressive age-related skeletal muscle disorder associated with harmful impacts on health. The present study aimed to investigate the relation between sarcopenia, platelet (PLT), white blood cell (WBC), and PLT to WBC ratio (PWR) due to the importance of early sarcopenia diagnosis.
Methods
This cross-sectional study was conducted based on the second stage of the Bushehr Elderly Health (BEH) Program. Sarcopenia was defined based on the revised edition of the European Working Group on Sarcopenia in Older People (EWGSOP2) in accordance with the Iranian cut-off point. Univariate and adjusted multivariate logistic regression and linear regression were used to evaluate the associations.
Results
The prevalence of sarcopenia among participants was 35.73 %. PLT count and PWR were statistically higher in severe sarcopenic participants, while no differences were seen in WBC. In crude analysis, sarcopenia was not associated with quartiles of PLT, WBC, and PWR, while after adjusting for age, marital status, and sex, the association was seen in the fourth quartile of PLT and PWR [OR (95%CI) = 1.40 (1.08 to 1.81), p-value = 0.009 for PLT; OR (95%CI) = 1.55 (1.20 to 2.00), p-value = 0.001 for PWR]. This association remained significant in the fully adjusted model [OR (95%CI) = 1.92 (1.25 to 2.95), p-value = 0.003 for PLT; OR (95%CI) = 1.64 (1.06 to 2.52), p-value = 0.024 for PWR]. Among sarcopenia parameters, PLT count was more likely to be associated with handgrip strength and muscle mass. After stratifying the participants by gender, sarcopenia parameters were no longer statistically significant in men.
Conclusion
This study showed that PLT and PWR were associated with sarcopenia after considering confounding factors, while this association was not seen in WBC. Moreover, results showed that gender had an important impact on sarcopenia parameters.
Photophysical Challenges and Antenna Effect Between Click Reaction-based Bodipy Derivatives Manufactured From Knorr Pyrrole
Authors: kursunlu ahmed nuri , Yilmaz Akif Kagan , Bastug Elif , Guler Ersin 
Published: September 2021

Abstract
In this paper, a series of click reaction-based Bodipy derivatives have been synthesized as part of a preliminary study. Following the characterization of the four challenger molecules, the photophysical properties (absorption, emission, excitation, molar absorption coefficient, quantum yield, etc.) were examined in various organic solvents. The results showed that the energy transfer from the Bodipy cores to other moieties was calculated between 71% and 93% depending on different π-electron configurations and chromophore groups.
Dynamics and Mass Balance of Polycyclic Aromatic Hydrocarbons in and around the Seto Inland Sea, Japan
Authors: Tsuji Hiroaki , Akiyoshi Yuta , Asakawa Daichi , Nakashita Shinya , Iwamoto Yoko , Sakugawa Hiroshi , Takeda Kazuhiko 
Published: September 2021

Abstract
Polycyclic aromatic hydrocarbons (PAHs) were analyzed to elucidate the distribution, ecological risk, pathways, and fluxes of these pollutants in and around the Seto Inland Sea, Japan. High molecular weight PAHs (5–6 rings) were primarily found in regions close to the bay estuaries, and their proportions decreased at distances further from the estuaries (offshore areas), where low molecular weight PAHs (2–4 rings) were more ubiquitous. Ecological risk assessments revealed that the PAHs found in the sediments should have no adverse effects on benthic communities, with the exception of fluorene, which was detected in high levels in the sediment from Beppu Bay. A mass balance for PAHs in the Seto Inland Sea, calculated based on data collected in the field and published literature findings, showed the PAH flux into the Seto Inland Sea from atmospheric deposition were ca. 5 times higher than that from riverine inflows. Comparison of the amount of the PAH flux between the Seto Inland Sea and other seas suggested that the Seto Inland Sea is less polluted than the Gulf of Lion and the Bohai Sea, and more polluted than the Yellow Sea.
A Novel Ferroptosis-Related lncRNAs Signature Predicts Clinical Prognosis and is Associated with Immune Landscape in Pancreatic Cancer
Authors: Ping Haiqin , Jia Xingqing , Ke Hengning 
Published: September 2021

Abstract
Pancreatic cancer is one of the most lethal malignancies and currently therapies are severely lacking. In this study, we aimed to establish a novel ferroptosis-related lncRNAs signature to predict the prognosis of patients with pancreatic cancer and evaluate the predictive abilities of candidate lncRNAs. According to The Cancer Genome Atlas (TCGA) database, a total of 182 patients with pancreatic cancer were included in our study. Ferroptosis-related lncRNAs were screened by Pearson correlation analysis with 60 reported ferroptosis-related genes. Through univariate, least absolute shrinkage and selection operator (LASSO) regression and multivariate regression analyses, a novel signature based on five ferroptosis-related lncRNAs(ZNF236-DT, CASC8, PAN3-AS1, SH3PXD2A-AS1, LINP1) was constructed. Risk-related differentially expressed genes (DEGs) were subjected to enrichment analyses for Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis.The results revealed that that immune cell infiltration, immune-related functions and checkpoints were factors to affect prognoisis of pancreatic cancer. In summary, we identified the prognostic ferroptosis-related lncRNAs in pancreatic cancer and these lncRNAs may serve as therapeutic targets for pancreatic cancer.
Pigmented Villonodular Synovitis of the Temporomandibular Joint with Skull Base Extension: A Retrospective Case Series
Authors: He Qiang , Zan Xin , Chen Fei , You Chao , Xu Jianguo 
Published: September 2021

Abstract
Background: Pigmented villonodular synovitis (PVNS) of the temporomandibular joint (TMJ) with skull base extension is a rare entity. Here, we summarize the clinical features, treatments, and outcomes of PVNS of the TMJ with skull base extension in a large case series. Methods: We reviewed the clinical information relating to patients diagnosed with PVNS of the TMJ with skull base extension information of patients in our center between 2011 and 2020. Results: We reviewed 10 patients (4 males and 6 females). All cases had presented with a unilateral lesion extending the middle skull base. PVNS of the TMJ with skull base extension occurred on the left side in 6 patients (60%) and on the right side in 4 patients (40%). Of the 10 patients, pain and mass were the most prevalent symptoms. All patients received surgery and no recurrence was seen after 35.90±25.35 months follow-up. Conclusion: Despite destructive biological behavior, surgery can achieve an excellent outcome for patients with PVNS of the TMJ with skull base extension. An en bloc resection may prevent recurrence and provide long-term relief. Radiotherapy may be reserved for subtotal excision and recurrent lesions but require further investigation.
Regulation of the unfolded protein response transducer IRE1α by SERPINH1 aggravates periodontitis with diabetes mellitus via prolonged ER stress
Authors: Li Mengdi , Huang Shuheng , Zhang Yong , Song Zhi , Fu Haijun , Lin Zhengmei , Huang Xin 
Published: September 2021

Abstract
Background
The hyperglycemic microenvironment induced by diabetes mellitus aggravates the inflammatory response, in which the inositol-requiring enzyme-1α (IRE1α) signal transduction pathway of the unfolded protein response (UPR) participates. This study aimed to investigate the mechanism by which hyperglycemia regulates the IRE1α signaling pathway and affects endoplasmic reticulum (ER) homeostasis in human gingival epithelium in periodontitis with diabetes mellitus (DP).
Methods
Human gingival epithelium samples from healthy subjects, subjects with periodontitis and subjects with DP were collected, in vitro cultures of human gingival epithelial cells were challenged with a hyperglycemic microenvironment to observe the effects of diabetes on periodontal inflammation and to assess UPR-IRE1α signaling in human gingival epithelium in DP. Subsequently, RNA sequencing (RNA-seq) data was analyzed to investigate the expression of ER-related genes in human gingival epithelium. Furthermore, to explore the key role of serpin family H member 1 (SERPINH1) in the regulation of UPR-IRE1α signaling in a hyperglycemic microenvironment, experiments in SERPINH1-knockdown and SERPINH1-overexpression models were established in vitro.
Results
Diabetes causes a hyperinflammatory response in human gingival epithelium, which accelerates periodontal inflammation. A hyperglycemic microenvironment inhibited the inositol-requiring enzyme-1α / X-box binding protein 1 (IRE1α/XBP1) axis, decreased the expression of glucose regulated protein 78 (GRP78), and ultimately impaired the UPR, causing ER stress to be prolonged or more severe in human gingival epithelium. The RNA-seq and experiments revealed that the mechanism by which periodontitis is aggravated in individuals with diabetes mellitus may involve decreased SERPINH1 expression. SERPINH1 might act as an activator of IRE1α, maintaining human gingival epithelium homeostasis, suppressing nuclear factor-κB signaling pathway and reducing NOD-like receptor, pyrin domain containing protein 3 (NLRP3) and interleukin-1 beta (IL-1β) expression by preventing prolonged ER stress induced by high-glucose conditions.
Conclusion
Regulation of the UPR transducer IRE1α by SERPINH1 alleviates DP by mitigating prolonged ER stress.
Early Prone Positioning in Acute Respiratory Distress Syndrome Related to COVID-19: A Propensity Score Analysis from the Multicentric Cohort COVID-ICU network. The ProneCOVID Study.
Authors: TERRIER Christophe LE , Sigaud Florian , Lebbah Said , Desmedt Luc , Hajage David , Guérin Claude , Pugin Jérôme , Primmaz Steve , Terzi Nicolas 
Published: September 2021

Abstract
Background Delaying time to prone positioning (PP) may be associated with higher mortality in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). We evaluated the use and the impact of early PP on clinical outcomes in intubated patients hospitalized in intensive care units (ICUs) for COVID-19.Methods All intubated patients with ARDS due to COVID-19 were involved in a secondary analysis from a prospective multicenter cohort study of COVID-ICU network including 149 ICUs across France, Belgian and Switzerland. Patients were followed-up until Day-90. The primary outcome was survival at Day-60. Analysis used a Cox proportional hazard model including a propensity score. Results Among 2137 intubated patients, 1504 (70.4%) were placed in PP during their ICU stay, and 491 (23%) during the first 24 hrs following ICU admission. One hundred and eighty-one patients (36.9%) of the early PP group had a PaO2/FiO2 ratio > 150 mmHg when prone positioning was initiated. Among non-early PP group patients, 1013 (47.4%) patients had finally been placed in PP within a median delay of 3 days after ICU admission. Day-60 mortality in non-early PP group was 34.2% vs. 39.3% in the early PP group (p = 0.038). Day-28 and Day-90 mortality as well as the need for adjunctive therapies were more important in patients with early PP. After propensity score adjustment, no significant difference in survival at Day-60 was found between the two-study groups (HR 1.34 [0.96-1.68], p=0.09 and HR 1.19 [0.998-1.412], p=0.053 in complete case analysis or in multiple imputation analysis, respectively).Conclusions In a large multicentric international cohort of intubated ICU patients with ARDS due to COVID-19, PP has been used frequently as a main treatment. In this study, early PP started within 24 hrs after ICU admission was not associated with a survival benefit compared to PP after day 1.
Enzymatic Synthesis of Cellulose in Space: Gravity Is a Crucial Factor for Building Cellulose II Gel Structure
Authors: Kuga Tomohiro , Sunagawa Naoki , Igrashi Kiyohiko 
Published: September 2021

Abstract
We previously reported in vitro synthesis of highly ordered crystalline cellulose II by reverse reaction of cellodextrin phosphorylase from the cellulolytic bacterium Clostridium ( Hungateiclostridium ) thermocellum ( Ct CDP), but the formation mechanism of the cellulose crystals and highly ordered structure has long been unclear. Considering the specific density of cellulose versus water, the formation of crystalline and highly ordered structure in an aqueous solution should be affected by gravity. Thus, we synthesized cellulose with Ct CDP at the International Space Station, where sedimentation and convection due to gravity are negligible. Optical microscopic observation suggested that cellulose in space has a gel-like appearance without apparent aggregation, in contrast to cellulose synthesized on the ground. Small-angle Xray scattering (SAXS) and wide-angle X-ray scattering (WAXS) indicated that cellulose synthesized in space has a more uniform particle distribution in the ~100 nm scale region than cellulose synthesized on the ground. Scanning electron microscopy (SEM) showed that both celluloses have a micrometer scale network structure, whereas a fine fiber network was constructed only under microgravity. These results indicate that gravity plays a role in cellulose II crystal sedimentation and the building of network structure, and synthesis in space could play a role in the design of unique materials.
Inhibition of MiR-20a by Pterostilbene Facilitates Prostate Cancer Cells Killed by NK Cells Via up-Regulation of NKG2D Ligands and Down-Regulation of TGF-β1
Authors: Li Zhang , Simin Liang , Jian Kang , Xin Gou , Kuang Youlin 
Published: September 2021

Abstract
Purpose-Natural killer (NK) cells play a potent role in antitumor immunity via spontaneously eliminating tumor directly. However, some tumors such as prostate cancer constantly escape this immune response by down-regulating cell surface molecule recognition and/or secreting immune impressive cytokines. Pterostilbene, a dietary compound primarily found in blueberries, exhibits a potential anti-tumor activities and immunoregulation function. However, whether it could affect NK cells immune response against prostate cancer is not clear.Methods-NK cell cytotoxicity against prostate cancer cells was analyzed using the CytoTox 96 cytotoxicity assay kit. Flow cytometry was used to detected NK cell degranulation, NK cell-surface and intracellular protein expression. The effects of pterostilbene on TGF-β1 secretion were determined by Enzyme-linked immunosorbent assay. The candidate target gene of miR-20a was determined by luciferase reporter assay and the expression of major histocompatibility complex class I chain-related proteins A and B (MICA/B) was detected by quantitative real-time polymerase chain reaction.Results-We found pterostilbene could enhance expression of MICA/B on prostate cancer cells surface, which are ligands of the natural killer group 2 member D (NKG2D) expressed by NK cells, and inhibit TGF-β1 secretion by prostate cancer cells. Further, we discovered that these effects were caused by inhibition of miR-20a in prostate cancer cells by pterostilbene. MiR-20a could target the 3’ untranslated region (UTR) of MICA/B, resulting in their expression down-regulation. Inhibition of TGF-β1 function by its specific antibody attenuated its impairment to NKG2D on NK cells. Finally, we observed that pterostilbene-treated prostate cancer cells were more easily to be killed by NK cells.Conclusions-Our findings demonstrated inhibition of miR-20a by pterostilbene in prostate cancer cells could increase MICA/B expression and decrease TGF-β1 secretion, which enhanced NK cell-mediated cytotoxicity againt prostate cancer cells, suggesting a potential approach for increasing anti-prostate cancer immune.
Extractable quantum work from a two-mode Gaussian state in a noisy channel
Authors: Cuzminschi Marina , Aurelian Isar , Zubarev Alexei 
Published: September 2021

Abstract
We study a Szilard engine based on a Gaussian state of a system consisting of two bosonic modes placed in a noisy channel. As the initial state of the system is taken an entangled squeezed thermal state, and the quantum work is extracted by performing a measurement on one of the two modes. We use the Markovian Kossakowski-Lindblad master equation for describing the time evolution of the open system and the quantum work definition based on the second order R\'{e}nyi entropy to simulate the engine. We show that the extractable quantum work increases with the temperature of the reservoir and the squeezing between the modes, average numbers of thermal photons and frequencies of the modes. The work increases also with the strength of the measurement, attaining the maximal values in the case of a heterodyne detection. As well the extractable work is decreasing by increasing the squeezing parameter of the noisy channel and it oscillates with the phase of the squeezed thermal reservoir.
Comparison of Flexion Relaxation Phenomenon Between Female Yogis and Matched Non- Athlete Group
Authors: Ramezani Marzyeh , Yoosefinejad Amin Kordi , Motealleh Alireza , Ghofrani-Jahromi Mohsen 
Published: September 2021

Abstract
Background: Trunk flexion is a common exercise during daily activities. Flexion relaxation phenomenon (FRP) occurs during forward bending in which there is a sudden silence of erector spinae (ES) muscles. The pattern of forward bending differs in yoga practitioners. This learned pattern probably predisposes yogis to injuries.The hypothesis of this study was that FRP differs in yogis in comparison to non-yogis individuals.Methods: This observational cross-sectional study was performed on 60 women assigned into yogis and non-athlete groups. Each participant was asked to bend forward and then return to the initial position. ES activity was recorded at L3 level, 4 cm from mid line during the trial. Trunk inclination and lumbar flexion angles were calculated at FRP onset and cessation moments. Results: The FRP phenomenon occurred in 80% of yoga practitioners in comparison to 96.7% in the control group. Trunk inclination angle was significantly greater at FRP initiation in yogis compared to control group. Lumbar flexion angle was not different between the groups. Conclusions: It is concluded that the altered pattern of forward bending observed in yogis may change patterns of ES muscles activity if it becomes part of a person's daily lifestyle which might predispose these muscles to fatigue and subsequent injuries.
The Relationship Between Ethical Awareness in Nursing Profession, and Moral Sensitivity in Nurses of Hamadan University of Medical Sciences, Iran.
Authors: Mohammadi Ziba , Darderafshi Sahel , Akhlaghi Mahboubeh , Makvandi Zeinab 
Published: September 2021

Abstract
Background: knowledge about moral principles and having moral sensitivity lead to the right decision in nurses when facing moral problems. This study aimed to investigate the relationship between ethical awareness in the nursing profession and moral sensitivity in nurses of Hamadan University of Medical Sciences in 2018.Methods: In this cross-sectional study, 333 nurses working in teaching hospitals of Hamadan University of Medical Sciences participated; selected by stratified sampling method with proportional allocation. Data collection tools included demographic information form, and questionnaires of ethics awareness in the nursing profession, and moral sensitivity. Data normality was assessed by Kolmogorov-Smirnov test and according to which, parametric t-test and ANOVA or non-parametric Mann-Whitney and Kruskal-Wallis tests were done in SPSS 24.Results: The results showed that the overall mean score of nurses' awareness and moral sensitivity was moderate. Also, the majority of nurses had a moderate level of awareness (65.3%) and moral sensitivity (80.4%). The level of ethics awareness by gender and the level of moral sensitivity in according to gender, marital status, shift work and employment status were significantly different (p <0.05). The findings showed that there was no statistically significant correlation between ethical awareness and moral sensitivity in nurses.Conclusion: given to the moderate level of awareness and moral sensitivity of nurses, efforts should be made to improve and promote ethical issues in nursing. It is also recommended to conduct more tailoring studies to teaching the principles of ethical awareness and moral sensitivity and to recognizing the factors affecting them.
An Integrated Analysis of Prognostic and Immune Infiltrates for Hub Genes as Potential Survival Indicators in Patients with Lung Adenocarcinoma
Authors: Xu Zhiyun , Wang Shi , Ren Zhijian , Gao Xiang , Xu Lin , Ren Binhui 
Published: September 2021

Abstract
Objective: Lung adenocarcinoma is one of the major subtypes of lung cancer. However, the prognosis of individuals with LUAD is still not promising. Therefore, this research aims to discover useful biomarkers to enhance the treatment and diagnosis of LUAD.Methods: GEO2R was used to identify common up-regulated DEGs in the GSE32863, GSE40791 and GSE75037. The DEGs were submitted to Metascape for gene ontology and pathway enrichment analysis. Metascape was also utilized to construct the PPI network, and the MCODE plug-in was employed to filter important subnetworks. The prognosis and expression levels of the hub genes were evaluated using the UALCAN, GEPIA2, and Kaplan-Meier plotter databases. The Timer database was utilized to confirm the correlation between immune cells infiltration and the expression levels of hub genes in LUAD tissues.Results: This research discovered 307 common up-regulated DEGs, and gene ontology and pathway enrichment analysis indicated that they were mostly enriched in mitotic cell cycle process and cell cycle pathway. DEGs in the subnetwork with the largest number of genes were AURKB, CCNB2, CDC20, CDCA5, CDCA8, CENPF and KNTC1. The seven hub genes were highly expressed in LUAD tissues and had a poor prognosis. AURKB, CCNB2, and CDC20 were inversely associated with B and CD4+ T cells. CDCA5, CDCA8, and CENPF have a substantially negative correlation with B Cell, but positive correlation with Neutrophil. Conclusions: This research demonstrates that increased expression of seven hub genes is associated with worse prognosis for LUAD patients. Additionally, immune cells infiltrating LUAD tissues may serve as a regulating mechanism.