bluuebunny/crossref_metadata_2025_split huggingface dataset:
Future changes to high impact weather in the UK
Authors: Hanlon Helen M. , Bernie Dan , Carigi Giulia , Lowe Jason A. 
Published: June 2021

AbstractHigh impact weather events such as extreme temperatures or rainfall can cause significant disruption across the UK affecting sectors such as health, transport, agriculture and energy. In this study we draw on the latest set of UK climate projections, UKCP, to examine metrics relating to high-impact weather over the UK and how these change with different levels of future global warming from 1.5 °C to 4 °C above pre-industrial. The changes to these hazards show increases in the frequency of extremely hot days and nights, with a UK average increase in hot days of between 5 and 39 days per year between 1.5 °C and 4 °C of global warming. Projections indicate an increase in cooling degree days of 134–627% and an increase in growing degree days of 19–60% between 1.5 °C and 4 °C of global warming. Extremely hot nights, which are currently rare, are emerging as more common occurrences. The frequency of high daily temperatures and rainfall increase systematically, while the frequency of very cold conditions (based on days where temperatures fall below 0 °C) is shown to decrease by 10 to 49 days per year. A reduction in heating degree days, of 11–32% between 1.5 °C and 4 °C of warming, is projected. Levels of daily rainfall, which currently relate to increased risk of river flooding, are shown to increase across the country, with increases of days with high impact levels of rainfall occurring by 1 to 8 days per year between 1.5 °C and 4 °C of warming. Average drought severity is projected to increase for 3-, 6-, 12- and 36-month-long droughts. The largest changes in the severity of the 12-month drought are between −3 and +19% between 1.5 °C and 4 °C of warming and for 36-month drought between −2 and +54% between 1.5 °C and 4 °C of warming. The projected future changes in high impact weather from this study will enable the characterization of climate risks and ultimately be able to better inform adaptation planning in different sectors to support the increase in resilience of the UK to future climate variability and change.
Perspectives of Patients and Providers in Using Shared Decision Making in Psychiatry
Authors: Maples Natalie J. , Velligan Dawn I. , Jones Eric C. , Espinosa Erin M. , Morgan Robert O. , Valerio-Shewmaker Melissa A. 
Published: June 2021

AbstractThere is increased interest over the last decade in the use of Shared Decision Making with individuals with serious mental illness to improve engagement in treatment and clinical outcomes. We conducted semi-structured qualitative interviews with 15 individuals with serious mental illness treated in an outpatient transitional care clinic serving people immediately after discharge from a psychiatric hospitalization. Parallel interviews were conducted with a variety of clinical providers (n = 9). Using latent thematic analysis, six themes were identified including: (1) Differences in the Use of SDM, (2) Consideration of Past Experiences, (3) Decisional Power Preferences, (4) Use of SDM in Psychiatry Versus Other Areas of Medicine, (5) Dignity and Disengagement, and (6) External Forces Impacting SDM. Implications for clinical practice and research using a shared decision-making approach within this treatment setting are further discussed.
TSPO protein binding partners in bacteria, animals, and plants
Authors: Hiser Carrie , Montgomery Beronda L. , Ferguson-Miller Shelagh 
Published: June 2021

AbstractThe ancient membrane protein TSPO is phylogenetically widespread from archaea and bacteria to insects, vertebrates, plants, and fungi. TSPO’s primary amino acid sequence is only modestly conserved between diverse species, although its five transmembrane helical structure appears mainly conserved. Its cellular location and orientation in membranes have been reported to vary between species and tissues, with implications for potential diverse binding partners and function. Most TSPO functions relate to stress-induced changes in metabolism, but in many cases it is unclear how TSPO itself functions—whether as a receptor, a sensor, a transporter, or a translocator. Much evidence suggests that TSPO acts indirectly by association with various protein binding partners or with endogenous or exogenous ligands. In this review, we focus on proteins that have most commonly been invoked as TSPO binding partners. We suggest that TSPO was originally a bacterial receptor/stress sensor associated with porphyrin binding as its most ancestral function and that it later developed additional stress-related roles in eukaryotes as its ability to bind new partners evolved.
Weaving a web of reliable thermochemistry around lignin building blocks: phenol, benzaldehyde, and anisole
Authors: Verevkin Sergey P. 
Published: June 2021

Abstract
Substituted benzenes such as phenol, benzaldehyde, and anisole are the simplest fragments from the lignin separation feedstocks. We have collected available primary experimental results on vapour pressures, enthalpies of phase transition, and enthalpies of combustion of phenol, benzaldehyde, and anisole. The resulting data on the gas-phase standard molar enthalpies of formation were validated using the quantum chemical method G4. The consistent sets of evaluated thermodynamic data are essential for calculating the energy balances of lignin conversion in the value-added chemicals and materials.

Graphic abstract
The “Haves, Have Some, and Have Nots:” a Latent Profile Analysis of Capacity, Quality, and Implementation in Community-Based Afterschool Programs
Authors: Smith Emilie Phillips , Witherspoon Dawn P. , Lei Pui-Wa 
Published: June 2021

AbstractImplementation of evidence-based practices is a critical factor in whether afterschool programs are successful in having a positive impact upon risk reduction and positive youth development. However, important prevention research reveals that contextual and organizational factors can affect implementation (Bradshaw & Pas in School Psychology Review, 40, 530–548, 2011) (Flaspohler et al., in American Journal of Community Psychology, 50(3-4), 271-281, 2012) (Gottfredson et al., Prevention Science, 3, 43–56, 2002) (McIntosh et al., Journal of Positive Behavior Interventions, 18(4), 209-218, 2016) (Payne in Prevention Science, 10, 151–167, 2009). Using a latent profile approach (LPA), this paper examines multiple organizational and neighborhood contextual factors that might affect the degree to which afterschool programs effectively implement evidence-based practices in the context of a cluster-randomized trial of the Paxis Good Behavior Game (PaxGBG). The Interactive Systems Framework (ISF) explores dimensions of capacity that might matter for prevention efforts. As expected, we found that well-resourced and high-quality programs performed well in terms of implementation (the Haves) and, in neighborhood contexts rich in racial-ethnic diversity. Yet, we found that some programs with less physical and material capacity (the Have Nots), demonstrated greater program quality (i.e., supportive adult and peer relationships, engagement, a sense of belonging) and implementation, relative to programs with better capacity (e.g., space, material resources, staffing, and leadership, the Have Somes). While capacity matters, intentional prevention initiatives that seek to promote evidence-based practices are helpful to sites in supporting organizations that might otherwise fail to provide quality programming for youth. This paper addresses a conundrum in prevention science, namely, how to make programming accessible to those who need it with a focus on organizational processes, program quality, and implementation of evidence-based practices.
Beyond logic there is only nonsense
Authors: Woleński Jan 
Published: June 2021

AbstractThis paper provides an interpretation of Father Bocheński’s saying “Beyond logic there is only nonsense.” He considered the battle against superstitions of various kinds as one of the most important intellectual and social duties. The phrase in itself suggests that logic is a weapon in the mentioned battle. Logic is understood broadly, that is, as semantics, formal logic and the methodology of science, and was considered by Bocheński as the main instrument of rational philosophy. Hence, the formula under discussion has an explicit metaphilosophical significance, although Bochenski’s understanding of the concept of differs from that of the Vienna Circle.
Spatial and temporal evolution of an experimental debris flow, exhibiting coupled fluid and particulate phases
Authors: Chalk C. M. , Peakall J. , Keevil G. , Fuentes R. 
Published: June 2021

AbstractThe internal behaviour of debris flows provides fundamental insight into the mechanics responsible for their motion. We provide robust velocity data within a small-scale experimental debris flow, consisting of the instantaneous release of a granular material along a rectangular flume, inclined at $$31^{\circ }$$

31
∘

. The results show a unique layered transition from a collisional, turbulent front to a non-fluctuating viscous-type flow body, exhibiting strong fluid-particulate coupling. This is the first time that the internal dynamics have been documented within the full architecture of a developing experimental debris flow, from the head to the tail.
Toward a better understanding of team decision processes: combining laboratory experiments with agent-based modeling
Authors: Lorscheid Iris , Meyer Matthias 
Published: June 2021

AbstractDespite advances in the field, we still know little about the socio-cognitive processes of team decisions, particularly their emergence from an individual level and transition to a team level. This study investigates team decision processes by using an agent-based model to conceptualize team decisions as an emergent property. It uses a mixed-method research design with a laboratory experiment providing qualitative and quantitative input for the model’s construction, as well as data for an output validation of the model. First, the laboratory experiment generates data about individual and team cognition structures. Then, the agent-based model is used as a computational testbed to contrast several processes of team decision making, representing potential, simplified mechanisms of how a team decision emerges. The increasing overall fit of the simulation and empirical results indicates that the modeled decision processes can at least partly explain the observed team decisions. Overall, we contribute to the current literature by presenting an innovative mixed-method approach that opens and exposes the black box of team decision processes beyond well-known static attributes.
The Toxicological Risk Assessment of Dermal Exposure of Patients Exposed to Nickel and Chromium due to Application of Ointments with Marjoram Herb Extract (Majoranae Herbae Extractum) Available in Polish Pharmacies
Authors: Jurowski Kamil , Fołta Maria , Tatar Barbara , Berkoz Mehmet , Krośniak Mirosław 
Published: June 2021

AbstractFor elemental impurities that have been studied for transcutaneous absorption, the available data are rarely suitable for proper toxicological risk assessment — there are multiple factors that can influence this dermal absorption. Hence, in our studies, we applied generic and conservative approach — cutaneous permitted daily exposure (CPDE) described in International Conference on Harmonisation’s Q3D Guideline on Elemental Impurities (ICH Q3D). The aim of this article is toxicological risk assessment (TRA) of dermal exposure of patients exposed to nickel and chromium due to application of ointments with Marjoram herb extract (Majoranae herbae extractum) available in Polish pharmacies (n = 5, because only five manufacturers produce this kind of pharmaceutical products in Poland). To make the appropriate TRA approach, we considered (1) raw results (metal per kg of ointment), (2) one-time administration of applied ointments, and (3) daily exposure versus CPDE. Due to the fact the concentrations of Ni generally present in cutaneous products as impurities are not considered sufficient to induce sensitization, the cutaneous and transcutaneous concentration limits (CTCLs) approach was applied for this element assessment. The toxicological analysis was carried out using microwave-assisted wet digestion with concentrated nitric acid and electrothermal atomization atomic absorption spectrometry. Our results show that the ointments with Marjoram herb extract from pharmacies in Poland represent a potential health hazard to patients; however, there may be a requirement for the monitoring of impurities of nickel in future. To the best of our knowledge, this paper is the first study about nickel and chromium content in ointments with Marjoram herb extract (Majoranae herbae extractum).
Pathogenic variants in plakophilin-2 gene (PKP2) are associated with better survival in arrhythmogenic right ventricular cardiomyopathy
Authors: Biernacka Elżbieta K. , Borowiec Karolina , Franaszczyk Maria , Szperl Małgorzata , Rampazzo Alessandra , Woźniak Olgierd , Roszczynko Marta , Śmigielski Witold , Lutyńska Anna , Hoffman Piotr 
Published: June 2021

AbstractArrhythmogenic right ventricular cardiomyopathy (ARVC) is mainly caused by mutations in genes encoding desmosomal proteins. Variants in plakophilin-2 gene (PKP2) are the most common cause of the disease, associated with conventional ARVC phenotype. The study aims to evaluate the prevalence ofPKP2variants and examine genotype–phenotype correlation in Polish ARVC cohort. All 56 ARVC patients fulfilling the current criteria were screened for genetic variants inPKP2using denaturing high-performance liquid chromatography or next-generation sequencing. The clinical evaluation involved medical history, electrocardiogram, echocardiography, and follow-up. Ten variants (5 frameshift, 2 nonsense, 2 splicing, and 1 missense) inPKP2were found in 28 (50%) cases. All truncating variants are classified as pathogenic/likely pathogenic, while the missense variant is classified as variant of uncertain significance. Patients carrying aPKP2mutation were younger at diagnosis (p = 0.003), more often had negative T waves in V1–V3 (p = 0.01), had higher left ventricular ejection fraction (p = 0.04), and were less likely to present symptoms of heart failure (p = 0.01) and left ventricular damage progression (p = 0.04). Combined endpoint of death or heart transplant was more frequent in subgroup withoutPKP2mutation (p = 0.03). Pathogenic variants inPKP2are responsible for 50% of ARVC cases in the Polish population and are associated with a better prognosis. ARVC patients withPKP2mutation are less likely to present left ventricular involvement and heart failure symptoms. Combined endpoint of death or heart transplant was less frequent in this group.
End-to-End Autonomous Driving Through Dueling Double Deep Q-Network
Authors: Peng Baiyu , Sun Qi , Li Shengbo Eben , Kum Dongsuk , Yin Yuming , Wei Junqing , Gu Tianyu 
Published: June 2021

AbstractRecent years have seen the rapid development of autonomous driving systems, which are typically designed in a hierarchical architecture or an end-to-end architecture. The hierarchical architecture is always complicated and hard to design, while the end-to-end architecture is more promising due to its simple structure. This paper puts forward an end-to-end autonomous driving method through a deep reinforcement learning algorithm Dueling Double Deep Q-Network, making it possible for the vehicle to learn end-to-end driving by itself. This paper firstly proposes an architecture for the end-to-end lane-keeping task. Unlike the traditional image-only state space, the presented state space is composed of both camera images and vehicle motion information. Then corresponding dueling neural network structure is introduced, which reduces the variance and improves sampling efficiency. Thirdly, the proposed method is applied to The Open Racing Car Simulator (TORCS) to demonstrate its great performance, where it surpasses human drivers. Finally, the saliency map of the neural network is visualized, which indicates the trained network drives by observing the lane lines. A video for the presented work is available online,https://youtu.be/76ciJmIHMD8orhttps://v.youku.com/v_show/id_XNDM4ODc0MTM4NA==.html.
Repeated Pelvic Radiographs in Infants, After Harness Treatment for Developmental Dysplasia of the Hip, Carry Very Low Radiation Risk
Authors: Vogel Elizabeth , Leaver Thomas , Wall Fiona , Johnson Ben , Uglow Michael , Aarvold Alexander 
Published: June 2021

Abstract
Objective
There are no data on the effect of X-Ray irradiation to the vulnerable pelvic organs of babies during DDH follow-up. This study aims to calculate, for the first time, the radiation exposure to infants during follow-up for DDH harness treatment, and thus quantify the lifetime risk of malignancy.

Methods
Patients who had completed 5 years’ follow-up following successful Pavlik harness treatment were identified from the hospital DDH database. The radiation dose was extracted from the Computerised Radiology Information System database for every radiograph of every patient. The effective dose (ED) was calculated using conversion coefficients for age, sex and body region irradiated. Cumulative ED was compared to Health Protection Agency standards to calculate lifetime risk of malignancy from the radiographs.

Results
All radiographs of 40 infants, successfully treated in Pavlik harness for DDH, were assessed. The mean number of AP pelvis radiographs was 7.00 (range: 6–9, mode: 7). The mean cumulative ED was 0.25 mSv (Range: 0.11–0.46, SD: 0.07). This is far lower than the annual ‘safe’ limit for healthcare workers of 20 mSv and is categorised as “Very Low Risk”.

Conclusion
Clinicians involved in the treatment DDH can be re-assured that the cumulative radiation exposure from pelvic radiographs following Pavlik harness treatment is “Very Low Risk”. Whilst being mindful of any radiation exposure in children, this study provides a scientific answer that help addresses parental concerns.
Pelvic Floor Muscle Training Effect in Sexual Function in Postmenopausal Women: A Randomized Controlled Trial
Authors: Franco Maíra M. , Pena Caroline C. , de Freitas Leticia M. , Antônio Flávia I. , Lara Lucia A.S. , Ferreira Cristine Homsi Jorge 
Published: June 2021

ABSTRACTBackgroundThe prevalence of sexual dysfunction is high in postmenopausal women and pelvic floor muscle training (PFMT) could improve sexual function during this period.AimTo assess the effect of a PFMT protocol on sexual function in postmenopausal women and to investigate the effect of this protocol on pelvic floor muscle function.MethodsThis is an assessor blinded randomized controlled trial including 77 postmenopausal women. The study was registered in ReBEC Trial: RBR-3s3ff7. The intervention group (n = 40) received an intensive supervised PFMT protocol during 12 weeks and the control group (n = 37) received no intervention.OutcomesThe primary outcome of the study was assessed by the Female Sexual Function Index (FSFI) questionnaire and the secondary outcome was the evaluation of pelvic floor muscle function performed by digital palpation using the modified Oxford scale at baseline and after 12 weeks.RESULTSNo difference between groups was found in the FSFI domains and total score at baseline and in the second evaluation after 12 weeks. However, after 12 weeks, a higher percentage of women without sexual dysfunction was found in the intervention group (95% CI = 27.97–72.03) when compared to the control group (95% CI = 7.13–92.87). No difference was found between groups in relation to the pelvic floor muscle function at the baseline (P = .2) and after 12 weeks (P = .06).Clinical ImplicationsPFMT is a conservative intervention that can lead women to have less sexual dysfunction.Strengths & LimitationsThe protocol provided a reduced number of women with sexual dysfunction, the strength of this research is the study design and the limitation is to have used only one tool to assess sexual function although it is a validated questionnaire.CONCLUSIONPFMT decreases sexual dysfunction in postmenopausal women.
Turkish pre-service early childhood education teachers’ perceptions and practices of nature-based teaching on professional experience
Authors: Karaarslan Semiz Güliz , Temiz Zeynep 
Published: June 2021

AbstractThis paper considers the perceptions and teaching practices of Turkish pre-service early childhood education teachers with regard to nature-based teaching. Nature-based activities rarely take place in Turkish early childhood education settings; accordingly, there is a clear need to develop pre-service teachers’ professional experience related to nature-based teaching to empower them to support children’s learning in natural environments. In this study, eight pre-service teachers applied nature-based teaching in a professional experience placement over a period of 10 weeks. Clarke and Peterson’s (1986) model of teachers’ thoughts and actions guided this study in terms of understanding pre-service teachers’ related perceptions and practices. Qualitative data were collected through activity plans and semi-structured interviews, the findings from which revealed that the implementation of various activities using natural materials and the natural environment increased pre-service teachers’ self-confidence related to nature-based teaching. The primary barriers to the implementation of nature-based teaching activities were reported as being the attitudes of families and school management, weather conditions and pre-service teachers’ lack of knowledge of nature-based pedagogies. These barriers could be addressed by supporting pre-service early childhood teachers’ professional development and by affording them more opportunities to perform nature-related activities in early childhood settings.
“Greetings from the Apocalypse”: Race, Migration, and Fear after German Reunification
Authors: Molnar Christopher A. 
Published: June 2021

AbstractIn the early 1990s, reunified Germany faced surging numbers of asylum seekers and a wave of far-right violence against foreigners. In letters that German citizens wrote to President Richard von Weizsäcker, it is clear that some Germans feared that the arrival of large numbers of non-Germans would bring about the collapse of the state or the destruction of the German people. This article engages with the history of fear in postwar Germany by examining Germans’ post-reunification fears of migration and foreigners. I argue, first, that a biological understanding of race was still surprisingly widespread as late as the early 1990s. Second, I call for a substantially more nuanced understanding of German reunification, one that emphasizes uncertainty and the terrifying openness of the future. Finally, I highlight the intersection of race thinking and memory by showing that racial fears were frequently shaped by memories of Germany's dark past.