bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes
Authors: Lu Yingchang , Dimitrov Latchezar , Chen Shyh-Huei , Bielak Lawrence F. , Bis Joshua C. , Feitosa Mary F. , Lu Lingyi , Kavousi Maryam , Raffield Laura M. , Smith Albert V. , Wang Lihua , Weiss Stefan , Yao Jie , Zhu Jiaxi , Gudmundsson Elias F. , Gudmundsdottir Valborg , Bos Daniel , Ghanbari Mohsen , Ikram M. Arfan , Hwang Shih-Jen , Taylor Kent D. , Budoff Matthew J. , Gíslason Gauti K. , O’Donnell Christopher J. , An Ping , Franceschini Nora , Freedman Barry I. , Fu Yi-Ping , Guo Xiuqing , Heiss Gerardo , Kardia Sharon L.R. , Wilson James G. , Langefeld Carl D. , Schminke Ulf , Uitterlinden André G. , Lange Leslie A. , Peyser Patricia A. , Gudnason Vilmundur G. , Psaty Bruce M. , Rotter Jerome I. , Bowden Donald W. , Ng Maggie C.Y. 
Published: July 2021

Background:
Coronary artery calcification (CAC) and carotid artery intima-media thickness (cIMT) are measures of subclinical atherosclerosis in asymptomatic individuals and strong risk factors for cardiovascular disease. Type 2 diabetes (T2D) is an independent cardiovascular disease risk factor that accelerates atherosclerosis.

Methods:
We performed meta-analyses of genome-wide association studies in up to 2500 T2D individuals of European ancestry (EA) and 1590 T2D individuals of African ancestry with or without exclusion of prevalent cardiovascular disease, for CAC measured by cardiac computed tomography, and 3608 individuals of EA and 838 individuals of African ancestry with T2D for cIMT measured by ultrasonography within the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium.

Results:

We replicated 2 loci (rs9369640 and rs9349379 near
PHACTR1
and rs10757278 near
CDKN2B
) for CAC and one locus for cIMT (rs7412 and rs445925 near
APOE-APOC1
) that were previously reported in the general EA populations. We identified one novel CAC locus (rs8000449 near
CSNK1A1L/LINC00547/POSTN
at 13q13.3) at
P
=2.0×10
-8
in EA. No additional loci were identified with the meta-analyses of EA and African ancestry. The expression quantitative trait loci analysis with nearby expressed genes derived from arterial wall and metabolic tissues from the Genotype-Tissue Expression project pinpoints
POSTN
, encoding a matricellular protein involved in bone formation and bone matrix organization, as the potential candidate gene at this locus. In addition, we found significant associations (
P
<3.1×10
-4
) for 3 previously reported coronary artery disease loci for these subclinical atherosclerotic phenotypes (rs2891168 near
CDKN2B-AS1
and rs11170820 near
FLJ12825
for CAC, and rs7412 near
APOE
for cIMT).

Conclusions:
Our results provide potential biological mechanisms that could link CAC and cIMT to increased cardiovascular disease risk in individuals with T2D.
Cost‐Utility of Catheter Ablation for Atrial Fibrillation in Patients with Heart Failure: An Economic Evaluation
Authors: Lau Darren , Sandhu Roopinder K. , Andrade Jason G. , Ezekowitz Justin , So Helen , Klarenbach Scott 
Published: July 2021

Background
Recent trials comparing catheter ablation to medical therapy in patients with heart failure (HF) with symptomatic atrial fibrillation despite first‐line management have demonstrated a reduction in adverse outcomes. We performed an economic evaluation to estimate the cost‐utility of catheter ablation as second line therapy in patients with HF with reduced ejection fraction.

Methods and Results
A Markov model with health states of alive, dead, and alive with amiodarone toxicity was constructed, using the perspective of the Canadian healthcare payer. Patients in the alive states were at risk of HF and non‐HF hospitalizations. Parameters were obtained from randomized trials and Alberta health system data for costs and outcomes. A lifetime time horizon was adopted, with discounting at 3.0% annually. Probabilistic and 1‐way sensitivity analyses were performed. Costs are reported in 2018 Canadian dollars. A patient treated with catheter ablation experienced lifetime costs of $64 960 and 5.63 quality‐adjusted life‐years (QALY), compared with $49 865 and 5.18 QALYs for medical treatment. The incremental cost‐effectiveness ratio was $35 360/QALY (95% CI, $21 518–77 419), with a 90% chance of being cost‐effective at a willingness‐to‐pay threshold of $50 000/QALY. A minimum mortality reduction of 28%, or a minimum duration of benefit of >1 to 2 years was required for catheter ablation to be attractive at this threshold.

Conclusions
Catheter ablation is likely to be cost‐effective as a second line intervention for patients with HF with symptomatic atrial fibrillation, with incremental cost‐effectiveness ratio $35 360/QALY, as long as over half of the relative mortality benefit observed in extant trials is borne out in future studies.
Ten‐year Outcomes After Drug‐Eluting Stents or Bypass Surgery for Left Main Coronary Disease in Patients With and Without Diabetes Mellitus: The PRECOMBAT Extended Follow‐Up Study
Authors: Jeong Yeong Jin , Ahn Jung‐Min , Hyun Junho , Lee Junghoon , Kim Ju Hyeon , Yang Yujin , Choe Kyungjin , Park Hanbit , Kang Do‐Yoon , Lee Pil Hyung , Kang Soo‐Jin , Lee Seung‐Whan , Kim Young‐Hak , Lee Cheol Whan , Park Seong‐Wook , Park Seung‐Jung , Park Duk‐Woo 
Published: July 2021

Background
Several trials reported differential outcomes after percutaneous coronary intervention with drug‐eluting stents (DES) and coronary‐artery bypass grafting (CABG) for multivessel coronary disease according to the presence of diabetes mellitus (DM). However, it is not well recognized how DM status affects very‐long‐term (10‐year) outcomes after DES and CABG for left main coronary artery disease.

Methods and Results

In the PRECOMBAT (Premier of Randomized Comparison of Bypass Surgery versus Angioplasty using Sirolimus‐Eluting Stent in Patients with Left Main Coronary Artery Disease) trial, patients with LMCA were randomly assigned to undergo PCI with sirolimus‐eluting stents (n=300) or CABG (n=300). The primary outcome was the incidence of major adverse cardiac or cerebrovascular events (MACCE; a composite of death from any cause, myocardial infarction, stroke, or ischemia‐driven target‐vessel revascularization). Outcomes were examined in patients with (n=192) and without (n=408) medically treated diabetes. The follow‐up was extended to at least 10 years for all patients (median, 11.3 years). The 10‐year rates of MACCE were not significantly different between DES and CABG in patients with DM (36.3% versus 26.7%, respectively; hazard ratio [HR], 1.35; 95% CI, 0.83–2.19;
P
=0.23) and without DM (25.3% versus 22.9%, respectively; HR, 1.15; 95% CI, 0.79–1.67;
P
=0.48) (
P
‐for‐interaction=0.48). There were no significant between‐group differences in composite of death, MI, or stroke, and all‐cause mortality, regardless of DM status. TVR rates were consistently higher after DES than CABG.

Conclusions
In this 10‐year extended follow‐up of PRECOMBAT, we found no significant difference between DES and CABG with respect to the incidences of MACCE, serious composite outcome, and all‐cause mortality in patients with and without DM with LMCA disease. However, owing to the limited number of patients and no adjustment for multiple testing, overall findings should be considered hypothesis‐generating, highlighting the need for further research.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03871127 and NCT00422968.
Root Dilatation Is More Malignant Than Ascending Aortic Dilation
Authors: Kalogerakos Paris D. , Zafar Mohammad A. , Li Yupeng , Mukherjee Sandip K. , Ziganshin Bulat A. , Rizzo John A. , Elefteriades John A. 
Published: July 2021

Background
Data from the International Registry of Acute Aortic Dissection indicate that the guideline criterion of 5.5 cm for ascending aortic intervention misses many dissections occurring at smaller dimensions. Furthermore, studies of natural behavior have generally treated the aortic root and the ascending aorta as 1 unit despite embryological, anatomical, and functional differences. This study aims to disentangle the natural histories of the aforementioned aortic segments, allowing natural behavior to define specific intervention criteria for root and ascending segments of the aorta.

Methods and Results

Diameters of the aortic root and mid‐ascending segment were measured separately. Long‐term complications (dissection, rupture, and death) were analyzed retrospectively for 1162 patients with ascending thoracic aortic aneurysm. Cox regression analysis suggested that aortic root dilatation (
P
=0.017) is more significant in predicting adverse events than mid‐ascending aortic dilatation (
P
=0.087). Short stature posed as a serious risk factor. The dedicated risk curves for the aortic root and the mid‐ascending aorta revealed hinge points at 5.0 and 5.25 cm, respectively.

Conclusions
The natural histories of the aortic root and mid‐ascending aorta are uniquely different. Dilation of the aortic root imparts a significant higher risk of adverse events. A diameter shift for intervention to 5.0 cm for the aortic root and to 5.25 cm for the mid‐ascending aorta should be considered at expert centers.
Factors Associated With Health‐Related Quality of Life 2 Years After Left Ventricular Assist Device Implantation: Insights From INTERMACS
Authors: Grady Kathleen L. , Fazeli Pariya L. , Kirklin James K. , Pamboukian Salpy V. , White‐Williams Connie 
Published: July 2021

Background
Factors related to health‐related quality of life (HRQOL) 2 years after left ventricular assist device (LVAD) implantation are unknown. We sought to determine whether preimplant intended goal of LVAD therapy (heart transplant candidate [short‐term group], uncertain heart transplant candidate [uncertain group], and heart transplant ineligible [long‐term group]) and other variables were related to HRQOL 2 years after LVAD implantation.

Methods and Results

Our LVAD sample (n=1620) was from INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support). Using the EuroQol‐5 Dimension Questionnaire (EQ‐5D‐3L), a generic HRQOL measure, and the Kansas City Cardiomyopathy Questionnaire (KCCQ‐12), a heart failure–specific HRQOL measure, multivariable linear regression modeling was conducted with the EQ‐5D‐3L Visual Analog Scale (VAS) score and KCCQ‐12 overall summary score (OSS) as separate dependent variables. Two years after LVAD implant, the short‐term group had a significantly higher mean VAS score versus the uncertain and long‐term groups (short‐term: 75.18 [SD, 20.62]; uncertain: 72.27 [SD, 20.33]; long‐term: 70.87 [SD, 22.09],
P
=0.01); differences were not clinically meaningful. Two‐year mean scores did not differ by group for the KCCQ‐12 OSS (short‐term, 67.85 [SD, 20.61]; uncertain, 67.79 [SD, 19.31]; long‐term, 67.08 [SD, 21.49],
P
=0.80). Factors associated with a worse VAS score 2 years postoperatively (n=1205) included not working; not having a short‐term LVAD; and postoperative neurological dysfunction, greater health‐related stress, coping poorly, less VAD self‐care confidence, and less satisfaction with VAD surgery, explaining 28% of variance (
P
<0.001). Factors associated with a worse KCCQ‐12 OSS 2 years postoperatively (n=1250) included not working; history of high body mass index and diabetes mellitus; and postoperative renal dysfunction, greater health‐related stress, coping poorly, less VAD self‐care confidence, less satisfaction with VAD surgery, and regret regarding VAD implantation, accounting for 36% of variance (
P
<0.001).

Conclusions
Factors related to HRQOL 2 years after LVAD implantation include demographic, clinical, and psychological variables.
Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine‐1‐Phosphate
Authors: Del Gaudio Ilaria , Rubinelli Luisa , Sasset Linda , Wadsack Christian , Hla Timothy , Di Lorenzo Annarita 
Published: July 2021

Background
Most of the circulating sphingosine‐1‐phosphate (S1P) is bound to ApoM (apolipoprotein M) of high‐density lipoprotein (HDL) and mediates many beneficial effects of HDL on the vasculature via G protein–coupled S1P receptors. HDL‐bound S1P is decreased in atherosclerosis, myocardial infarction, and diabetes mellitus. In addition to being the target, the endothelium is a source of S1P, which is transported outside of the cells by Spinster‐2, contributing to circulating S1P as well as to local signaling. Mice lacking endothelial S1P receptor 1 are hypertensive, suggesting a vasculoprotective role of S1P signaling. This study investigates the role of endothelial‐derived S1P and ApoM‐bound S1P in regulating vascular tone and blood pressure.

Methods and Results
ApoM knockout (ApoM KO) mice and mice lacking endothelial Spinster‐2 (ECKO‐Spns2) were infused with angiotensin II for 28 days. Blood pressure, measured by telemetry and tail‐cuff, was significantly increased in both ECKO‐Spns2 and ApoM KO versus control mice, at baseline and following angiotensin II. Notably, ECKO‐Spns2 presented an impaired vasodilation to flow and blood pressure dipping, which is clinically associated with increased risk for cardiovascular events. In hypertension, both groups presented reduced flow‐mediated vasodilation and some degree of impairment in endothelial NO production, which was more evident in ECKO‐Spns2. Increased hypertension in ECKO‐Spns2 and ApoM KO mice correlated with worsened cardiac hypertrophy versus controls.

Conclusions
Our study identifies an important role for Spinster‐2 and ApoM‐HDL in blood pressure homeostasis via S1P‐NO signaling and dissects the pathophysiological impact of endothelial‐derived S1P and ApoM of HDL‐bound S1P in hypertension and cardiac hypertrophy.
_rt movements
Authors: Moreschi Bruno , Bratton Christopher , Benfield Dalida Maria , Pereira Gabriel , Falcão Guilherme 
Published: July 2021

Abstract
_rt Movement(s) is an artist research project intended as a text object that materially represents the complex, relational articulation of art and history with particular emphases on the contingent relationships made by movements of different kinds: geographical migration of artists, displacement of art objects, performances, institutions/festivals, and theories/theorists. _rt Movement(s) challenges the linear developmental approach of normative art history, and its nationalist, racialized, and ethnocentric assumptions. Instead, the project argues through diverse sources, including texts, images, graphs and other visualizations for the essentially translocal and transhistorical character of works of art.
Introduction to Jalal AL-E Ahmad's “To Mohassess, For
the Wall”
Authors: Mirzaei Mohammadreza 
Published: July 2021

Abstract
“To Mohassess, For the Wall” is an article written in 1964 by Jalal Al-e Ahmad, one of the most influential and charismatic Iranian intellectuals of the time. Three years before writing this article, Al-e Ahmad had published Weststruckness, discussing the Iranians’ cultural alienation caused by the dependence on the west. In “To Mohassess, For the Wall”, Al-e Ahmad shifts his analysis to Iranian painting, arguing that Iranian painters during the 1960s merely repeat Western cultural processes and strategies instead of constructing Iranian ones. The context for Al-e Ahmad's argument is the Pahlavi regime's radical program of rapid modernization, which in the area of the arts was systematically expanded. Critical, provocative or problematic, the article offers a crucial window into the adoption of Western-style modernism by Iranian painters during the 1960s and into how an “insider” intellectual such as Al-e Ahmad evaluated the modernization of Iranian art before the background of what he perceived as the critical neglect of Iranian traditions. The text is addressed to Bahman Mohassess, a painter whom Al-e Ahmad considered to be one of the few who had not been coopted by the cultural policies of the Shah's regime.
The DEPARTS Score: A Novel Tool for Predicting Discharge Disposition in Geriatric Trauma Patients
Authors: Yeates Eric O. , Grigorian Areg , Kuza Catherine M. , Nguyen Ninh T. , Inaba Kenji , Dolich Matthew , Nahmias Jeffry 
Published: July 2021

Background Geriatric trauma patients (GTPs) represent a high-risk population for needing post-acute care, such as skilled nursing facilities (SNFs) and long-term acute care hospitals (LTACs), due to a combination of traumatic injuries and baseline functional health. As there is currently no well-established tool for predicting these needs, we aimed to create a scoring tool that predicts disposition to SNFs/LTACs in GTPs. Methods The adult 2017 Trauma Quality Improvement Program database was divided at random into two equal sized sets (derivation and validation sets) of GTPs >65 years old. First, multiple logistic regression models were created to determine risk factors for discharge to a SNF/LTAC in admitted GTPs. Second, the weighted average and relative impact of each independent predictor was used to derive a DEPARTS ( Discharge of Elderly Patients After Recent Trauma to SNF/LTAC) score. We then validated the score using the area under the receiver-operating curve (AROC). Results Of 66 479 patients in the derivation set, 36 944 (55.6%) were discharged to a SNF/LTAC. Number of comorbidities, fall mechanism, spinal cord injury, long bone fracture, and major surgery were each independent predictors for discharge to SNF/LTAC, and a DEPARTS score was derived with scores ranging from 0 to 19. The AROC for this was .74. In the validation set, 66 477 patients also had a SNF/LTAC discharge rate of 55.7%, and the AROC was .74. Discussion The DEPARTS score is a good predictor of SNF/LTAC discharge for GTPs. Future prospective studies are warranted to validate its accuracy and clinical utility in preventing delays in discharge.
How do lipids influence risk of violence, self-harm and suicidality in people with psychosis? A systematic review
Authors: Sen Piyal , Adewusi Danielle , Blakemore Alexandra I , Kumari Veena 
Published: July 2021

Objectives: Low cholesterol has been linked with violent and suicidal behaviour in people with schizophrenia. This association, if consistently present, may be a promising biological marker that could assist clinicians in decision making regarding risk and treatment. We conducted a systematic review to assess whether there is a reliable association between lipid profile (total cholesterol, high- and low-density lipoprotein cholesterol, and triglycerides) and aggression, self-harm or suicide in people with schizophrenia, and whether effects are similar in males and females. Method: Relevant databases were searched to identify primary research studies (up to November 2020) that (1) involved adults (some samples also included 16- to 18-year olds) with a confirmed diagnosis of schizophrenia, schizoaffective disorder or psychosis; and (2) included a standardised assessment of verbal aggression, physical aggression against objects, physical aggression against self (including suicide) or others. The search yielded 23 studies eligible for inclusion following a quality appraisal. Results: Suicidality was the most commonly assessed subtype of aggression (20 studies). For suicidality, about half the studies, including the study with the largest sample size, found a link with total cholesterol. An association between low total cholesterol and violence towards others was found in six of nine studies that investigated this. The evidence for a link with violence was the strongest for total cholesterol, followed by low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, and the weakest for triglycerides. Only a few studies investigated sex differences and yielded mixed evidence. Studies focussed on self-harm as well as involving females in forensic settings were lacking. Conclusion: There is encouraging evidence of an association between low total cholesterol and aggression towards others as well as suicidality in schizophrenia. Future studies should systematically explore this association in people with schizophrenia who have a significant history of violence, suicidality and self-harm, both inpatients and community, and also investigate underlying mechanisms.
A critical review of the definition of ‘wellbeing’ for doctors and their patients in a post Covid-19 era
Authors: Simons Gemma , Baldwin David S 
Published: July 2021

Background: There is no international consensus definition of ‘wellbeing’. This has led to wellbeing being captured in many different ways. Aims: To construct an inclusive, global operational definition of wellbeing. Methods: The differences between wellbeing components and determinants and the terms used interchangeably with wellbeing, such as health, are considered from the perspective of a doctor. The philosophies underpinning wellbeing and modern wellbeing research theories are discussed in terms of their appropriateness in an inclusive definition. Results: An operational definition is proposed that is not limited to doctors, but universal, and inclusive: ‘Wellbeing is a state of positive feelings and meeting full potential in the world. It can be measured subjectively and objectively, using a salutogenic approach’. Conclusions: This operational definition allows the differentiation of wellbeing from terms such as quality of life and emphasises that in the face of global challenges people should still consider wellbeing as more than the absence of pathology.
Correlation between universities’ Altmetric Attention Scores and their performance scores in Nature Index, Leiden, Times Higher Education and Quacquarelli Symonds ranking systems
Authors: Moshtagh Maryam , Sotudeh Hajar 
Published: July 2021

Objective: Altmetrics are claimed to measure the scientific, societal, educational, technological and economic impacts of science. They have some of these dimensions in common with university ranking and evaluating systems. Their results are, therefore, expected to be partially convergent with the systems’. Given the importance of the scientific and non-scientific impacts of science, this study investigated the correlations of universities’ altmetrics with their total and dimensional scores in Nature Index, Leiden, Times Higher Education (THE) and Quacquarelli Symonds (QS). Methodology: Following a correlational design, it explored an available sample of the universities commonly ranked in the systems in 2017. The data were collected from online documents using checklists and analysed by the Spearman correlation. As Altmetric Attention Score (ASS) is efficient in that it integrates several indicators into a single one, it was used as the proxy of the universities’ social performance. Findings: The universities showed significant positive correlations between their ASSs and their performance scores on the total and dimensional levels, except for industry income in THE, with an insignificant correlation, and proportion of collaborative publication less than 100 km. in Leiden, with an inverse correlation. The correlations ranged from weak to marginally strong. Conclusion: The positive relationships between the universities’ performance and ASSs signified that there existed some similarities in what they measured. However, they were of weak-to-marginally strong powers, implying that the metrics differed in what they measured. The findings contribute to the existing knowledge by providing some evidence of convergence between university-level altmetrics and university performances in various dimensions.