bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulatory Role of Macrophage Migration Inhibitory Factor on Cytokines and Clinical Features of Sarcoidosis
Authors: Elahi Morvarid , Talreja Jaya , Koth Laura L. , Samavati Lobelia 
Published: December 2021

Abstract
Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology with a significant heterogeneity in organ manifestations, severity, and clinical course. Subjects with sarcoidosis share several features such as, non-necrotizing granuloma, hypergammaglobulinemia, increased local and circulating inflammatory cytokines, such as interleukin (IL)-6, IL-18, and interferon gamma (IFN-γ). Macrophage migration inhibitory factor (MIF) is a pluripotent chemokine produced by various cell types. The expression of MIF at sites of inflammation suggests a regulatory role in the function of macrophages. The objective of this study was to investigate the role of MIF in the serum and bronchoalveolar lavage (BAL) fluid of sarcoidosis patients in association with clinical features and other cytokines. Methods: Sera and BALs of sarcoidosis patients (n=55) were collected at the time of diagnosis and patients were followed longitudinally for 3 years. Additionally, fifteen healthy controls participated in the study. The medical records of all patients including, demographics, radiography stages, pulmonary function tests, and organ involvements were recorded. The levels of MIF, IL-18, IL-10, IL-6, IFN-γ and lysozyme in serum and BAL samples were measured by ELISA. Statistical analyses were performed using SPSS software. Results: Serum MIF had a remarkable positive correlation with IL-10 and IFN-γ but had a negative correlation with serum IgG levels. Importantly, longitudinal follow-up showed a positive correlation between MIF and % predicted diffusion capacity (%DLCO) at 3-year. Serum IL-18 had a significant positive correlation with serum lysozyme, but a negative correlation with % predicted total lung capacity at 3-year follow up. We identified two groups of sarcoidosis subjects with distinct clinical and cytokine features. A group with prominent extrapulmonary involvement, and low serum MIF, IL-10 and IFN-γ levels and a group with elevated serum MIF, IL-10 and IFN-γ levels. Moreover, we found a negative correlation between BAL IL-18 and BAL MIF in sarcoidosis subjects.Conclusions: Patients with low serum MIF, IL-10 and IFN-γ levels has severe and mostly extrapulmonary sarcoidosis with elevated lysozyme and IL-18 levels. Our work provides understanding of phenotypic diversity in association with heterogeneity in cytokine landscape in sarcoidosis.
Flexible, Sensitive, Multifunctional Rubber-based Sensor with Multiple Responses to Infrared, Temperature, Humidity and Strain
Authors: Zheng Zhongjie , Yang Li , Yang Yunpeng , Lin Baofeng , Fu Lihua , Xu Chuanhui 
Published: December 2021

Abstract
Flexible wearable electronic sensors have attracted immense interest in human motion detection, body temperature monitoring and personal healthcare monitoring. However, most of reported sensors cannot integrate multifunctional applications at the same time though they own excellent single achievement of strain sensing or humidity sensing. Herein, we fabricate a multifunctional rubber-based flexible sensor (MRFS) with responses to infrared, temperature, humidity and strain. The sensor owns a superior strength (5.66 MPa), high stretchability (367%), high temperature coefficient of resistance (2.046%/℃) and high photothermal conversion efficiency (78.6%). For the sensing applications, it shows a rapid sensing of only 0.5 s for the temperature and humidity changes as well as a sensitive response to low-powered near infrared of 0.14 W/cm2, body temperature change from 33.6 to 35.6 ℃, and small amount of moisture on human skin. Moreover, the MRFS shows a considerable strain sensing for human joint motion and an antibacterial property.
Future low-carbon electricity in Africa: how much material is needed?
Authors: Barron Karla Cervantes , Hakker Maaike E , Cullen Jonathan M 
Published: December 2021

Abstract
African countries are expected to experience some of the worst climate effects, while trying to provide higher electricity access and increase wellbeing.Concrete, steel, and aluminium pre­sent the largest opportunities for action, given their high mass or embodied emissions projections.Embodied emissions related to material use for electricity plants are evaluated in three scenarios: a refer­ence scenario, and two scenarios related to the Paris Agreement (where renewable energy increases), resulting in higher embodied emissions as renewables are integrated.Pursuing strategies to increase the use of renewables should be done along material efficiency strategies to reach the total low-carbon potential.
APROXIMAÇÕES ENTRE O LEGADO FREIREANO E A EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA: UMA ANÁLISE TEXTUAL DISCURSIVA DO ESTATUTO DO INSTITUTO FEDERAL FLUMINENSE
Authors: Rezende da Silva Arthur Da , Bastos Costa de Oliveira Rafael 
Published: December 2021

Este artigo objetiva investigar a relação entre o legado freireano e a Educação Profissional e Tecnológica (EPT), com base nesta questão: Em quais aspectos observa-se a influência de Paulo Freire no Instituto Federal Fluminense? Metodologicamente, optou-se pela técnica de análise de dados conceituada como Análise Textual Discursiva (ATD), a partir do documento institucional que reformula o Estatuto do IFF. A análise aponta a presença do legado freireano no Estatuto do IFF, por visar à formação emancipatória do estudante e oportunizar experiências de uma gestão democrática.
Relationship between meteorological and hydrological droughts in the upstream regions of the Lancang–Mekong River
Authors: Li Jiqiu , Wang Yinfei , Li Yungang , Ming Wenting , Long Yunshu , Zhang Mingda 
Published: December 2021

Abstract
Information on the relationship between meteorological drought (MD) and hydrological drought (HD) can serve as the basis for early warning and mitigation of HD. In this study, the standardized precipitation index and standardized streamflow index were applied to characterize MD and HD, respectively, and the evolution characteristics of MD and HD were assessed in the upstream regions of the Lancang–Mekong River (ULMR) from 1961 to 2015. Furthermore, the relationship between MD and HD was investigated using the Pearson correlation and wavelet analysis. The results revealed that (1) there was no significant change in the annual precipitation and streamflow; however, the ULMR experienced successive alternations of wet and dry episodes; (2) the average duration and magnitude of MD and HD increased with an increase in the time scale, while the duration and magnitude of MD lengthened and amplified in HD; (3) MD more likely propagated to HD as the time scale increased, and the propagation time exhibited marked seasonality, which was shorter in the wet season and longer in the dry season; and (4) there was a positive correlation between MD and HD; these two types of drought exhibited similar resonance frequency and phase-shift characteristics, and HD lagged behind MD.
Photocatalytic ozonation in an immersion rotary body reactor for the removal of micro-pollutants from the effluent of wastewater treatment plants
Authors: Mehling Simon , Schnabel Tobias , Londong Jörg 
Published: December 2021

Abstract
Carrier-bound titanium dioxide catalysts were used in a photocatalytic ozonation reactor for the degradation of micro-pollutants in real wastewater. A photocatalytic immersion rotary body reactor with a 36-cm disk diameter was used, and was irradiated using UV-A light-emitting diodes. The rotating disks were covered with catalysts based on stainless steel grids coated with titanium dioxide. The dosing of ozone was carried out through the liquid phase via an external enrichment and a supply system transverse to the flow direction. The influence of irradiation power and ozone dose on the degradation rate for photocatalytic ozonation was investigated. In addition, the performance of the individual processes photocatalysis and ozonation were studied. The degradation kinetics of the parent compounds were determined using liquid chromatography tandem mass spectrometry. First-order kinetics were determined for photocatalysis and photocatalytic ozonation. A maximum reaction rate of the reactor was determined, which could be achieved by both photocatalysis and photocatalytic ozonation. At a dosage of 0.4 mg /mg DOC, the maximum reaction rate could be achieved using 75% of the irradiation power used for sole photocatalysis, allowing increases in the energetic efficiency of photocatalytic wastewater treatment processes. The process of photocatalytic ozonation is suitable to remove a wide spectrum of micro-pollutants from wastewater.
Incidence of Restenosis Following Rapamycin or Paclitaxeleluting Stent in
Coronary Stent Implantation
Authors: Shakarami Amir 
Published: December 2021

Background & Objectives:
Coronary artery disease (CAD) is chiefly characterized by atherosclerosis
and plaque formation in coronary arteries. The aim of this study was to evaluate the correlation of
coronary anatomy as a predictor of restenosis and stent thrombosis in coronary artery disease
(CAD) patients 5 years after percutaneous coronary intervention (PCI).

Methods:
In this prospective study, 1070 patients with stent restenosis or stent thrombosis over
past 5 years were enrolled. Coronary angiography was performed to evaluate coronary restenosis
and stent thrombosis 5 years after PCI. Stent restenosis was defined as >50% angiographic in-stent
lumen reduction. Stent thrombosis was defined as sudden complete occlusion of stent presenting
with acute myocardial infarction in that territory. Demographic data, clinical features and anatomic
factors were prospectively reviewed. Baseline, procedural, and post-procedural characteristics of
patients were recorded for analysis.

Results :
Among demographic characteristics, cardiovascular risk factors (hypertension and diabetes
mellitus) and anatomic factors were predictive risk factors for restenosis/thrombosis,
p=0.001. The most common site for stent restenosis was proximal to the mid part of the LAD
artery, followed by RCA and LCX. A greater diameter of LCX, a greater angle of LM-LAD than
LM-LCX and left dominancy increase the incidence of LAD stent restenosis/thrombosis. In this
study, the least common restenosis/thrombosis rate in relation to the total number of PCI was in the
Ramus intermedius artery.

Conclusion:
The outcomes of the study indicated that anatomic factors can predict increased risk
of restenosis among CAD patients who underwent PCI.
Comparative In vitro Metabolism of Enflicoxib in Dogs, Rats, and Humans:
Main Metabolites and Proposed Metabolic Pathways
Authors: Solà Josep , Menargues Àngel , Homedes Josep , Salichs Marta , Serafini Maria Teresa , Encina Gregorio 
Published: December 2021

Background:
Enflicoxib is a non-steroidal anti-inflammatory drug of the coxib family
characterized by a long-lasting pharmacological activity that has been attributed to its active
metabolite E-6132.

Objective:
The aim of this work was to explore enflicoxib biotransformation in vitro in humans,
rats and dogs, and to determine its metabolic pathways.

Method:
Different in vitro test systems were used, including hepatocytes and liver and non-hepatic
microsomes. The samples were incubated with enflicoxib and/or any of its metabolites at 37°C
for different times depending on the test system. The analyses were performed by liquid chromatography
coupled with either radioactivity detection or high-resolution mass spectrometry.

Results:
Enflicoxib was efficiently metabolized by cytochrome P-450 into three main phase I
metabolites: M8, E-6132, and M7. The non-active hydroxy-pyrazoline metabolite M8 accounted
for most of the fraction metabolized in all the three species. The active pyrazol metabolite E-6132
showed a slow formation rate, especially in dogs, whereas metabolite M7 was a secondary metabolite
formed by oxidation of M8. In hepatocytes, diverse phase II metabolite conjugates were
formed, including enflicoxib glucuronide, M8 glucuronide, E-6132 glucuronide, M7 glucuronide,
and M7 sulfate. Metabolite E-6132 was most probably eliminated by a unique glucuronidation reaction
at a very low rate.

Conclusion:
The phase I metabolism of enflicoxib was qualitatively very similar among rats, humans
and dogs. The low formation and glucuronidation rates of the active enflicoxib metabolite
E-6132 in dogs are postulated as key factors underlying the mechanism of its long-lasting pharmacokinetics
and enflicoxib's overall sustained efficacy.
Agomelatine: An Astounding Sui-generis Antidepressant?
Authors: Zhang Jing , Zhou Qi-Gang , Naveed Muhammad , Li Lian-Di , Sheng Gang , Du Zi-Wei , Zhou Ya-Ping , Nan Sun , Zhu Ming-Yi 
Published: December 2021

:Major depressive disorder (MDD) is one of the foremost causes of disability and premature death worldwide. Although the available antidepressants are effective and well tolerated, they also have many limitations. Therapeutic advances in developing a new drug's ultimate relation between MDD and chronobiology, which targets the circadian rhythm, led to a renewed focus on psychiatric disorders. In order to provide a critical analysis about antidepressant properties of agomelatine, a detailed PubMed (Medline), Scopus (Embase), Web of Science (Web of Knowledge), Cochrane Library, Google Scholar, and PsycInfo search was performed using the following keywords: melatonin analog, agomelatine, safety, efficacy, adverse effects, pharmacokinetics, pharmacodynamics, circadian rhythm, sleep disorders, neuroplasticity, MDD, bipolar disorder, anhedonia, anxiety, generalized anxiety disorder (GAD), and mood disorders. Agomelatine is a unique melatonin analog with antidepressant properties and a large therapeutic index that improves clinical safety. Published articles revealed that agomelatine is a melatonin receptors (MT1 and MT2) agonist and 5HT2C receptor antagonist. The effects receptors' on melatonin receptors enable the resynchronization of irregular circadian rhythms with beneficial effects on sleep architectures. In this way, agomelatine is accredited for its unique mode of action, which helps to exert antidepressant effects and resynchronize the sleep-wake cycle. To sum up, an agomelatine has not only antidepressant properties but also has anxiolytic effects.
Preclinical Investigation of Radiopharmaceuticals: An Accurate and Multidisciplinary
Approach
Authors: Schillaci Orazio , Urbano Nicoletta , Scimeca Manuel , Bonanno Elena 
Published: December 2021

Background:
The development of less expensive and pivotal methodologies capable of
supporting the researchers in the radiopharmaceutical pre-clinical investigations could provide a
crucial incentive for conducting biomedical research involved in the realization of tailored target
therapies.

Objective:
The aim of this pilot study was to evaluate the capability of a digital autoradiography
system equipped with a laser scanning device to perform [18F] choline biodistribution evaluation in
a xenograft mouse model of prostate cancer.

Methods:
PC3 prostate cancer cells were used to develop NOD/SCID mice xenografts. The biodistribution
of the radiopharmaceuticals was evaluated at 30, 60, and 120 min after injecting in excised
organs by using a digital autoradiography system equipped with a super-resolution laser
screen. Histological and immunohistochemical analyses were performed to correlate the [18F] choline
uptake with morphological and molecular tumours characteristics.

Results:
The reported data clearly indicate the possibility of performing accurate biodistribution
studies using the digital autoradiographic system equipped with a super-resolution screen. Specifically,
a significant increase in the [18F] choline inhibitor uptake in PC3 tumours compared to heart,
bowel, liver, and kidney at both 30 and 60 min was observed. More importantly, the digital autoradiographic
system showed signal uptake almost exclusively in the PC3 tumors at 60 min post-injection.
Noteworthy, immunohistochemical analysis demonstrated a strong overlapping between the
[18F] choline uptake and the proliferation index (Ki67 expression).

Conclusions:
The use of an autoradiography system in pre-clinical investigations could shed new
light on the molecular mechanisms that orchestrate the tissues damage induced by therapeutical radiopharmaceuticals.
Data Collection Mechanisms in Health and Wellness Apps: Review and Analysis
Authors: Philip Ben Joseph , Abdelrazek Mohamed , Bonti Alessio , Barnett Scott , Grundy John 
Published: December 2021

Background
There has been a steady rise in the availability of health wearables and built-in smartphone sensors that can be used to collect health data reliably and conveniently from end users. Given the feature overlaps and user tendency to use several apps, these are important factors impacting user experience. However, there is limited work on analyzing the data collection aspect of mobile health (mHealth) apps.

Objective
This study aims to analyze what data mHealth apps across different categories usually collect from end users and how these data are collected. This information is important to guide the development of a common data model from current widely adopted apps. This will also inform what built-in sensors and wearables, a comprehensive mHealth platform should support.

Methods
In our empirical investigation of mHealth apps, we identified app categories listed in a curated mHealth app library, which was then used to explore the Google Play Store for health and medical apps that were then filtered using our selection criteria. We downloaded these apps from a mirror site hosting Android apps and analyzed them using a script that we developed around the popular AndroGuard tool. We analyzed the use of Bluetooth peripherals and built-in sensors to understand how a given app collects health data.

Results
We retrieved 3251 apps meeting our criteria, and our analysis showed that 10.74% (349/3251) of these apps requested Bluetooth access. We found that 50.9% (259/509) of the Bluetooth service universally unique identifiers to be known in these apps, with the remainder being vendor specific. The most common health-related Bluetooth Low Energy services using known universally unique identifiers were Heart Rate, Glucose, and Body Composition. App permissions showed the most used device module or sensor to be the camera (669/3251, 20.57%), closely followed by location (598/3251, 18.39%), with the highest occurrence in the staying healthy app category.

Conclusions
We found that not many health apps used built-in sensors or peripherals for collecting health data. The small number of the apps using Bluetooth, with an even smaller number of apps using standard Bluetooth Low Energy services, indicates a wider use of proprietary algorithms and custom services, which restrict the device use. The use of standard profiles could open this ecosystem further and could provide end users more options for apps. The relatively small proportion of apps using built-in sensors along with a high reliance on manual data entry suggests the need for more research into using sensors for data collection in health and fitness apps, which may be more desirable and improve end user experience.
Molecular characterization of pathogenic OTOA gene conversions in hearing loss patients
Authors: Laurent Sacha , Gehrig Corinne , Nouspikel Thierry , Amr Sami S , Oza Andrea , Murphy Elissa , Vannier Anne , Béna Frédérique Sloan , Carminho-Rodrigues Maria Teresa , Blouin Jean-Louis , Van Hélène Cao , Abramowicz Marc , Paoloni-Giacobino Ariane , Guipponi Michel 
Published: December 2021

Bi-allelic loss-of-function variants of OTOA are a well-known
cause of moderate-to-severe hearing loss. Whereas non-allelic homologous
recombination-mediated deletions of the gene are well known, gene
conversions to pseudogene OTOAP1 have been reported in the
literature but never fully described nor their pathogenicity assessed.
Here, we report two unrelated patients with moderate hearing-loss, who
were compound heterozygotes for a converted allele and a deletion
of OTOA. The conversions were initially detected through
sequencing depths anomalies at the OTOA locus after exome
sequencing, then confirmed with long range polymerase chain reactions.
Both conversions lead to loss-of-function by introducing a premature
stop codon in exon 22 (p.Glu787*). Using genomic alignments and long
read nanopore sequencing, we found that the two probands carry stretches
of converted DNA of widely different lengths (at least 9 kbp and around
900 bp,
respectively).
The role of transforming growth factor-β and of matrix metalloproteinase 9 in immunopathogenesis of endometriosis associated with infertility
Authors: G. D. Koval  
Published: December 2021

In the development of endometriosis and infertility, associated with it, immunological processes play an important role, ant they are characterized by high activity of cytokines and growth factors (e.g., transforming growth factor -β (TGF-β)) and increased invasiveness of ectopic endometrium, including activity of matrix metalloproteinases (MMP). TGF-β exhibits different biological properties and plays a key role in the migration, proliferation and differentiation of cells. The concentration of TGF-β in serum and peritoneal fluid of 65 women with external genital endometriosis and infertility has been studied. We found an increase of TGF -β in peritoneal fluid, which is associated with an increased activity of MMP9 in the ectopic endometrium.
Metabolic disorders in hypertension patients as scientific area of the department of family medicine
Authors: S. V. Biletskyi  , O. A. Petrynych  , T. V. Kazantseva  
Published: December 2021

The paper generalizes the results of a scientific research at the department of family medicine concerning the study of metabolic disorders in hypertension patients and their changes caused by a pathogeneticaly based treatment.
Description of day regimen for schoolchildren with tension-type headache
Authors: A. V. Vozniak  
Published: December 2021

In order to assess the correspondence of the day regimen main elements and dietary habits to physiological and hygienic demands they have been studied in 167 schoolchildren with headache caused by overstrain. According to the results of the study, it was revealed that the violation of the day regimen main elements and dietary habits is common. Thus, the duration of sleep in 59,9 % of children is less than the physiological norm, in 37,7 % of children the length of stay in the fresh air is insufficient, 62,9 % of children spend more time for doing their homework than it is required according to the standards, in 71,0 % of children the violation of dietary habits was revealed.
The state of protein peroxidation in the operative treatment of benign prostate hyperplasia
Authors: O. S. Fedoruk  , V. I. Zaitsev  , K. A. Vladychenko  , I. I. Iliuk  , V. V. Vizniuk  , M. S. Stepanchenko  
Published: December 2021

We investigated the dynamics of the parameters of the state of blood serum protein peroxidation in surgical treatment of 60 patients with benign prostate hyperplasia. Surgical intervention was performed to the extent of transurethral prostate resection. Statistically, reliable changes of protein peroxidation were established prior to surgical intervention incomparison with the control group and when comparing the preoperative indices with the results of the examination during the intra- and postoperative periods. A technique of determining the state of blood serum protein peroxidation has been ascertained and the expediency of monitoring these parameters has been substantiated.