bluuebunny/crossref_metadata_2025_split huggingface dataset:
How should leaders “sustain the legacy” of urban catholic schools? An exploration of catholic school and system leader perspectives
Authors: Miller Andrew F. , Moreno Vera Maria , Giunco Kierstin 
Published: January 2025

PurposeDiocesan systems of Catholic schools in the USA have been trying to make urban elementary schools more sustainable in an era of declining enrollment. This paper sought to better understand how system and school leaders conceptualize what it takes to “sustain the legacy” of these schools.Design/methodology/approachWe conducted a qualitative analysis of interview data collected from 44 Catholic system and school leaders, comparing leaders’ perspectives about what they believed urban Catholic school principals should be doing to contribute to sector reform initiatives.FindingsWe found system and school leaders agreed principals should take responsibility for “sustaining the legacy” of urban Catholic schools, but they disagreed about the ultimate purpose of sustaining these schools. These disagreements shaped the decisions each group believed principals should prioritize.Originality/valueWe demonstrate in this paper that a systemic reform lens is useful when attempting to make sense of whether or how certain conditions within diocesan systems as currently designed may account for ongoing and persistent organizational crises within the Catholic sector.
Empirical study on the determinants of Muslim tourists’ visit to Japan: do Muslim–friendly facilities and culture matter?
Authors: Rahmawati Yessi , Alhassan Usman , A’la Al Ma’rifatul , Rosyidi Luthfi Nur 
Published: January 2025

Purpose
This study empirically assessed the determinants of halal tourism to Japan while focusing on Muslim-friendly facilities and Japanese cultural sites.

Design/methodology/approach
The study uses data from 2013 to 2018 and the Spatial Econometrics–Random Effect estimation technique, which allows for controlling for regional dependency. Furthermore, it extends the traditional Gunn and Tripartite Model which describes tourism attractiveness by considering the influence of historical sites on inbound tourism alongside regional gross domestic product (RGDP) and infrastructural availability.

Findings
The findings of the study reveal the existence of spatial autocorrelation among the prefectures in Japan in attracting tourists. The empirical results show that the availability of Mosques or prayer rooms positively influences Muslim tourists inflow in Japan. However, we find no significant impact of halal restaurants on tourism demand. Furthermore, our findings confirm the effectiveness of the components of the Tripartite and Urban Tourism Attractiveness models. Specifically, we find that historical sites and regional GDP significantly influence Muslim tourists visit to Japan.

Originality/value
Our study makes novel contributions to the literature on halal tourism. To the best of our knowledge, this is the first study to apply the spatial econometric technique to study the determinants of tourism demand. The application of spatial econometrics allows us to provide evidence of regional dependence in formulating policies that affect tourism. Secondly, we offer a unique augmentation of Gunn’s tripartite model by including the effect of Muslim-friendly facilities as determinants of tourism demand. Lastly, this is the first study to offer insight on halal tourism in Japan by studying all the Japanese prefectures at the macro-level. Previous studies only consider small samples of tourists in specific prefectures, raising concerns about their external validity.
Privileges, and Permissions: Theorising Intersectionality and Cultures of Control in the Care of People Living With Dementia in Acute Hospital Settings
Authors: Mwale Shadreck , Northcott Andy , Featherstone Katie 
Published: January 2025

ABSTRACTA longstanding body of public enquiries and research identifies people living with dementia experience systemic inequalities within hospital settings, concluding a focus on improving care cultures is required. Drawing on a 3‐year multi‐sited hospital ethnography, this paper examines everyday cultures of care in NHS acute hospital wards to interrogate how ethnicity, gender and social class intersects to shape the care of people living with dementia. Drawing on Collins' concept of intersectionality and the relational nature of power, the analysis reveals that while cared for by diverse teams of healthcare professionals, a patients' age, ethnicity, gender and social class, as interconnected categories, influences the tightening of ward rules for some people living with dementia and the granting of significant privileges for others. Focussing on walking within the ward, with a large number of people living with dementia classified as ‘wandering’, we explore ways in which intersectional identities informed who was granted privileges to leave the bedside and ‘wander’ the ward, and who experienced further control. The paper concludes that institutional racism and attitudes to gender, social class and ageing permeate the routine organisation and delivery of care within NHS acute hospital wards to significantly impact people living with dementia, and in turn, increases the consideration of care pathways that emphasise their discharge to institutional settings.
Reframing Formalin: A Molecular Opportunity Enabling Historical Epigenomics and Retrospective Gene Expression Studies
Authors: Holleley Clare E. , Hahn Erin E. 
Published: January 2025

ABSTRACTFormalin preservation of museum specimens has long been considered a barrier to molecular research due to extensive crosslinking and chemical modification. However, recent optimisation of hot alkaline lysis and proteinase K digestion DNA extraction methods have enabled a growing number of studies to overcome these challenges and conduct genome‐wide re‐sequencing and targeted locus‐specific sequencing. The newest, and perhaps most unexpected utility of formalin preservation in archival samples is its ability to preserve in situ DNA‐protein interactions at a molecular level. Retrieving this signal provides information about the relative compaction or accessibility of the genome to the transcriptional machinery required for gene expression. Thus, exposure to formalin essentially corresponds to taking a snapshot of organism‐wide gene expression at the time of death. While DNA methylation and RNA‐Seq analyses of dried tissues have provided glimpses into historical gene regulation, these techniques were previously limited to skeletal or desiccated remains, offering only partial insights. By examining fluid‐preserved specimens, molecular tools can now be applied to a broader range of tissues, enabling more detailed tissue‐specific gene regulation profiling across vertebrates. In this review, we chronicle the historical use of formaldehyde in collections and discuss how targeted chromatin profiling with assays like MNase‐seq and FAIRE‐seq are surmounting fixation challenges and unlocking invaluable insights into historical genomes and gene expression profiles. The deeper integration of molecular genetics with museum collections bridges the gap between past and present and provides a vital tool that could help us predict and mitigate some of the impacts of future environmental change, novel pathogens, or invasive species.
Extreme weather events, climate expectations, and agricultural export dynamics
Authors: Nes Kjersti , Schaefer K. Aleks , Gammans Matthew , Scheitrum Daniel Paul 
Published: January 2025

AbstractRising temperatures and shifting precipitation patterns threaten agricultural yields in many key global production regions. This paper assesses the impact of growing‐season extreme weather events on agricultural export outcomes in the short run, as well as the association between agricultural exports and long‐run climate expectations and variance. Our analysis matches information on bilateral trade flows with high‐resolution, geospatial data on growing area, planting and harvest dates, and weather for three highly traded staple crops—maize, soybeans, and rice—which together account for almost half of global calorie consumption. We use an econometric gravity model to estimate the short‐run effects of weather volatility and a nonparametric series regression to infer long‐run climate‐export associations. We then use our estimates to simulate the effects of various climate and weather counterfactuals on the agricultural export landscape. We find that 2‐standard‐deviation extreme weather events (measured using the water balance deficit) reduce maize, rice, and soybean bilateral export values by 48.2%, 53.4%, and 21.7%, respectively. Our long‐run results imply that increases in the standard deviation of weather are associated with lower export values across all three crops. An increase in the frequency of extreme events has the potential to greatly shift current commodity export patterns. Understanding these shifting patterns of trade is necessary to implement trade policy that enables countries to leverage their evolving comparative advantages and ensure the effectiveness of trade as a tool mitigating the negative production effect of climate change.
Disparities in healthcare, STI testing, and PrEP access among newcomer sexual minority men in Canada's three largest urban centers
Authors: Palma Paolo A. , Skakoon‐Sparling Shayna , Dawson Jessie , Zandi Reza , Zhang Terri , Campbell Evan , Tan Darrell H. S. , Lachowsky Nathan J. , Cox Joseph , Lambert Gilles , Dvorakova Milada , Lal Allan , Jollimore Jody , Grace Daniel , Hart Trevor A. 
Published: January 2025

AbstractGay, bisexual, and other men who have sex with men (GBM) are more likely to be diagnosed with HIV and other sexually transmitted infections (STIs) compared with the general population. Although newcomers generally experience a health advantage in Canada compared with non‐immigrants and more established immigrants (i.e., healthy immigrant effect), they also experience disparities in access to healthcare services. These disparities, in turn, may lead to unique vulnerabilities for the sexual health of GBM immigrants. We examined disparities in healthcare access, STI testing, and HIV pre‐exposure prophylaxis (PrEP) use among immigrant and non‐immigrant GBM. Using baseline data (collected between February 2017 and August 2019) from a multisite cohort study of GBM in Toronto, Vancouver, and Montreal (n = 2449), we found that newcomer GBM (migrated ≤ 5 years prior) were less likely to report having a primary healthcare provider than non‐immigrants. This had a weak indirect effect in mediating both access to STI testing and the use of HIV PrEP. These disparities dissipated after controlling for migration precarity (e.g., refugees and those without permanent residency), suggesting that disparities in newcomer GBM healthcare access may, in part, be driven by the large number of newcomers with precarious migration statuses.Public Significance Statement: New immigrants tend to be less likely to have a primary healthcare provider or use other sexual health clinics, which can have adverse consequences for sexual health. This disparity appears to be largely concentrated among temporary foreign workers, international students, and refugees. Interventions should target policies that increase the number of primary healthcare providers, and address immigration policies that lead to fear of deportation due to one's health.
Sciatic Nerve Preservation in Robot‐Assisted Surgery for Initially Unresectable Primary Rectal Cancer: A Case Report
Authors: Mizuno Ryosuke , Okamura Ryosuke , Itatani Yoshiro , Kinoshita Hiromitsu , Aisu Yuki , Maekawa Hisatsugu , Hoshino Nobuaki , Hida Koya , Obama Kazutaka 
Published: January 2025

ABSTRACTRadical surgery for rectal cancer with bulky lateral pelvic lymph node (LPLN) metastasis involving the sciatic nerve presents both technical and oncological challenges. Preoperative multidisciplinary treatments have recently been anticipated to control the disease as well as to preserve organ function. A 51‐year‐old man, presenting with right buttock pain and impairment of walking, was diagnosed with sciatic nerve impairment due to right LPLN metastasis from rectal cancer. He was initially treated with palliative radiotherapy followed by FOLFOX plus bevacizumab. After 13 cycles of the chemotherapy, his symptoms disappeared and the LPLN shrank. Then, conversion surgery via robot‐assisted low anterior resection with right LPLN dissection was performed. Although he had moderate right leg pain postoperatively, there were no motor deficits or other complications. Pathological examination of the specimen revealed microscopic residual disease at the resection margin, but he is currently surviving recurrence‐free for 1.5 years. Preoperative multidisciplinary treatment enabled the preservation of the sciatic nerve in the robot‐assisted conversion surgery.
A Good Story but not the Whole Story: Stakeholder Theory as an Ethics of Capitalism
Authors: Hargrave Timothy , Smith Jeffery 
Published: January 2025

ABSTRACTThe term “stakeholder capitalism” has become part of our shared business lexicon. This is due in large part to the work of R. Edward Freeman and his collaborators who conceive of stakeholder theory not simply as an approach to ethics in business but also of a new narrative for the ethics of capitalism. We argue that stakeholder thought as it is developed in this literature remains deficient as an ethics of capitalism because it fails to fully appreciate the distinction between business firms as one institution of capitalism and capitalism as an interrelated network of institutions. Failing to appreciate this distinction thwarts any facile movement between the theory's account of the ethics of business, which is concerned with the aims that guide business management, and the ethics of capitalism, which is concerned with how various institutions should be designed as a system with an internal division of moral labor. This difference suggests a prospective way forward for stakeholder theory that focuses more attention on the responsibilities that business firms owe to support the legal and economic institutions of capitalism.
Systemic lupus erythematosus‐associated autoantibodies in sickle cell disease: Spontaneous emergence in a patient and in transgenic sickle mice
Authors: Sinha Urshita , Setty Suman , Pilon Céleste , Brown Julia J. , Ruiz Maria Armila , Ren Guohui , Rauch Joyce , Saraf Santosh L. , Levine Jerrold S. 
Published: January 2025

SummaryWe describe a patient with sickle cell disease (SCD) and elevated antiphospholipid antibodies (aPL) who developed multi‐organ failure resembling catastrophic antiphospholipid syndrome. Autoimmune screening revealed several autoantibodies characteristic of systemic lupus erythematosus (SLE). Notably, routinely housed and unmanipulated transgenic sickle mice displayed significantly elevated titres of aPL‐ and SLE‐associated autoantibodies. We hypothesize that SCD may be a risk factor not only for the development of aPL but also more widespread autoimmunity.
Improved Diagnostic Yield in Recessive Intellectual Disability Utilizing Systematic Whole Exome Sequencing Data Reanalysis
Authors: Fattahi Zohreh , Shokouhian Ebrahim , Peymani Fatemeh , Babanejad Mojgan , Beheshtian Maryam , Edizadeh Masoud , Molaei Negar , Alagha Parnian , Ghodratpour Fatemeh , Keshavarzi Fatemeh , Moghadam Masoumeh Goleyjani , Arzhangi Sanaz , Kahrizi Kimia , Najmabadi Hossein 
Published: January 2025

ABSTRACTRecent advances in next generation sequencing (NGS) have positioned whole exome sequencing (WES) as an efficient first‐tier method in genetic diagnosis. However, despite the diagnostic yield of 35%–50% in intellectual disability (ID) many patients still remain undiagnosed due to inherent limitations and bioinformatic short‐comings. In this study, we reanalyzed WES data from 159 Iranian families showing recessively inherited ID. The reanalysis was conducted with an initial clinical re‐evaluation of the patients and their families, followed by data reanalysis using two updated bioinformatic pipelines. In the first phase, the BWA‐GATK pipeline was utilized for alignment and variant calling, with subsequent variant annotation by the ANNOVAR tool. This approach yielded causative variants in 17 families (10.6%). Among these, six genes (MAZ, ACTR5, AKTIP, MIX23, SERPINB12, and CDC25B) were identified as novel candidates potentially associated with ID, supported by bioinformatics functional annotation and segregation analysis. In the second phase, families with negative results were reassessed using the Illumina DRAGEN Bio‐IT platform for variant‐calling, and Ilyome, a newly developed web‐based tool, for annotation. The second phase identified likely pathogenic variants in two additional families, increasing the total diagnostic yield to 11.9% which is consistent with other studies conducted on cohorts of patients with ID. In conclusion, identification of co‐segregating variants in six novel candidate genes in this study, emphasizes once more on the potential of WES reanalysis to uncover previously unknown gene‐disease associations. Notably, it demonstrates that systematic reanalysis of WES data using updated bioinformatic tools and a thorough review of the literature for new gene‐disease associations while performing phenotypic re‐evaluation, can improve diagnostic outcome of WES in recessively inherited ID. Consequently, if performed within a 1–3 year period, it can reduce the number of cases that may require other costly diagnostic methods such as whole genome sequencing.
Contemporary practices in abdominoperineal resection for early‐stage rectal cancer in the United States
Authors: Dhimal Totadri , Hilty Chu Bailey K. , Loria Anthony , Boyer Megan , Cai Xueya , Li Yue , Colugnati Fernando , Cupertino Paula , Ramsdale Erika E. , Fleming Fergal J. 
Published: January 2025

AbstractAimIn contrast to significant advances in organ preservation in locally advanced rectal cancer, the contemporary management of early‐stage rectal cancer, including the frequency of abdominoperineal resections, remains largely unexplored in the United States. Therefore, we assessed the utilization of neoadjuvant therapy and oncological resections in early‐stage rectal cancer patients.Study designThis is a retrospective cohort study of patients with cT1–T3N0 rectal cancer who underwent proctectomies between 2016 and 2022 in the National Surgical Quality Improvement Project proctectomy files. Multivariable logistic regression was used to identify factors associated with abdominoperineal resections and Kendall's tau statistics to evaluate clinical‐pathological staging agreement.ResultsIn all, 3078 patients (29.6% cT1–2N0, 70.4% cT3N0) were included with 55.3% of tumours <5 cm from the anal verge. Overall, 58.2% received neoadjuvant therapy within 3 months of surgery (30.6% for cT1–T2N0 vs. 69.8% for cT3N0, P < 0.001), and 58.6% underwent abdominoperineal resection (55.5% for cT1–T2N0 vs. 59.9% for cT3N0, P = 0.058). The adjusted odds of undergoing abdominoperineal resection were associated with increasing age (OR 1.4 per every 10‐year increase; 95% CI 1.2–1.5), cT3N0 tumours (OR 1.7; 95% CI 1.1–2.7) and tumour location <5 cm from the anal verge (OR 10.6; 95% CI 7.7–14.7). There was a weak clinical‐pathological T staging correlation (Kendal tau coefficient 0.25; 95% CI 0.20–0.29).ConclusionIn this large cohort of patients with early‐stage rectal cancer with high rates of neoadjuvant therapy, over half of patients underwent abdominoperineal resection and one in five had a pathological complete response. These findings underscore opportunities for organ preservation in early‐stage rectal cancer, suggesting that treatments typically reserved for locally advanced disease may extend to early stages with the completion of ongoing clinical trials.
The Diagnostic Utility of PRAME in Primary Cutaneous Dedifferentiated and Transdifferentiated Melanomas
Authors: Choy Audrey , Wang Alex , Thayaparan Ganesha K. , Beaumont Luke , Williams Richard , Diab Sara , Tzaikou George , Ajmal Ayesha , Nirenberg Alexander 
Published: January 2025

ABSTRACTMelanomas show a wide spectrum of clinical, morphological, immunohistochemical, and molecular features, which can impact treatment and prognosis. Dedifferentiated and transdifferentiated melanomas (DTM) are defined as melanomas which have lost conventional melanocytic morphologic and immunohistochemical features, showing sarcomatous morphology and/or immunohistochemical staining of other cell lineages, and as such, can be mistaken for other entities such as collision tumors and undifferentiated spindle cell tumors. In this series, we highlight the utility of preferentially expressed antigen in melanomas (PRAME) in diagnosing undifferentiated/dedifferentiated melanomas. Case 1 is a lentigo maligna melanoma with dedifferentiation on the scalp of an 85‐year‐old. Case 2 is a desmoplastic melanoma with leiomyosarcomatous transdifferentiation on the cheek of an 80‐year‐old. Case 3 is a desmoplastic melanoma with rhabdomyosarcomatous transdifferentiation arising from the temple of an 88‐year‐old. In all cases, conventional melanocytic immunohistochemical markers were positive in the conventional melanoma and negative in the dedifferentiated/transdifferentiated areas. However, PRAME was positive in both the conventional and dedifferentiated areas with varying intensity. Although PRAME immunoreactivity can be seen in other malignant spindle cell tumors, this study highlights the potential utility of PRAME immunohistochemistry when considering a diagnosis of DTM.
Real‐world management of patients with complete response under immune‐checkpoint inhibition for advanced melanoma
Authors: Reitmajer Markus , Livingstone Elisabeth , Thoms Kai‐Martin , Heppt Markus V. , Meiss Frank , Gesierich Anja , Drexler Konstantin , Heinzerling Lucie , Meier Friedegund , Menzer Christian , Schlaak Max , Zimmer Lisa , Forschner Andrea 
Published: January 2025

SummaryBackgroundUp to now, the optimal duration of immune checkpoint inhibitors (ICI) has not been evaluated in prospective studies. However, current clinical practice requires decisions to be made regarding the duration of ICI in complete responders.Material and MethodsA survey was sent to 80 DeCOG skin cancer centers to assess how decisions are made on treatment duration of ICI in melanoma after having reached complete response, and staging intervals after ICI discontinuation. All responses received by March 10, 2024 (51 centers) were included.ResultsThe duration of ICI after having achieved complete remission varies between centers from three to 36 months. In total, 66% of the DeCOG centers continue treatment for up to 6 months, after having achieved complete remission (CR) with ICI. In the first year after discontinuation of ICI, most centers perform staging intervals (CT/MRI) every 3 months. More than 60% of centers continue staging at least once per year even in the 4th and 5th year after discontinuation.ConclusionsThere are significant differences between the centers regarding staging intervals and duration of ICI upon CR. Prospective studies are necessary to determine the optimal time point of ICI discontinuation and follow‐up.