bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor-Infiltrating PD-1hiCD8+-T-Cell Signature as an Effective Biomarker for Immune Checkpoint Inhibitor Therapy Response Across Multiple Cancers
Authors: Yang Zhenyu , Deng Yulan , Cheng Jiahan , Wei Shiyou , Luo Hao , Liu Lunxu 
Published: September 2021

BackgroundStratification of patients who could benefit from immune checkpoint inhibitor (ICI) therapy is of much importance. PD-1hiCD8+ T cells represent a newly identified and effective biomarker for ICI therapy response biomarker in lung cancer. Accurately quantifying these T cells using commonly available RNA sequencing (RNA-seq) data may extend their applications to more cancer types.MethodWe built a transcriptome signature of PD-1hiCD8+ T cells from bulk RNA-seq and single-cell RNA-seq (scRNA-seq) data of tumor-infiltrating immune cells. The signature was validated by flow cytometry and in independent datasets. The clinical applications of the signature were explored in non-small-cell lung cancer, melanoma, gastric cancer, urothelial cancer, and a mouse model of breast cancer samples treated with ICI, and systematically evaluated across 21 cancer types in The Cancer Genome Atlas (TCGA). Its associations with other biomarkers were also determined.ResultsSignature scores could be used to identify the PD-1hiCD8+ T subset and were correlated with the fraction of PD-1hiCD8+ T cells in tumor tissue (Pearson correlation, R=0.76, p=0.0004). Furthermore, in the scRNA-seq dataset, we confirmed the capability of PD-1hiCD8+ T cells to secrete CXCL13, as well as their interactions with other immune cells. In 581 clinical samples and 204 mouse models treated with ICIs, high signature scores were associated with increased survival, and the signature achieved area under the receiver operating characteristic curve scores of 0.755 (ranging from 0.61 to 0.91) in predicting therapy response. In TCGA pan-cancer datasets, our signature scores were consistently correlated with therapy response (R=0.78, p&lt;0.0001) and partially explained the diverse response rates among different cancer types. Finally, our signature generally outperformed other mRNA-based predictors and showed improved predictive performance when used in combination with tumor mutational burden (TMB). The signature score is available in the R package “PD1highCD8Tscore” (https://github.com/Liulab/PD1highCD8Tscore).ConclusionThrough estimating the fraction of the PD-1hiCD8+ T cell, our signature could predict response to ICI therapy across multiple cancers and could serve as a complementary biomarker to TMB.
Motor Development in Children With Autism Spectrum Disorder
Authors: Mohd Nordin Ashikin , Ismail Juriza , Kamal Nor Norazlin 
Published: September 2021

Objective: This study was conducted to determine the gross and fine motor profiles of children with autism spectrum disorder compared to typically developing children. Additionally, we also assessed if the motor delay was more pronounced with increasing age.Method: This was a retrospective study involving children aged 12–60 months of age comparing motor development in children with autism spectrum disorder with typically developing children. Their developmental profile was assessed using Schedule of Growing Skills II. Descriptive statistics was used to analyse the developmental profile between the groups.Results: ASD children had significant gross motor (6.7%) and fine motor delay (38.5%) compared to typically developing children, who did not show any delay. The motor delay in ASD children was more prominent in older children.Conclusion: It is important to assess motor development in ASD children as there is significant motor delay in these children compared to typically developing children, and the delay becomes more prominent with age. Early detection of motor delay could allow provision of early intervention services to optimize developmental outcomes.
Effect of Apixaban Pretreatment on Alteplase-Induced Thrombolysis: An In Vitro Study
Authors: Thalerová Sandra , Pešková Michaela , Kittová Patrícia , Gulati Sumeet , Víteček Jan , Kubala Lukáš , Mikulík Robert 
Published: September 2021

Benefit of thrombolytic therapy in patients with acute stroke, who are on anticoagulant treatment, is not well addressed. The aim of this study was to investigate whether apixaban can modify the thrombolytic efficacy of alteplase in vitro. Static and flow models and two variants of red blood cell (RBC) dominant clots, with and without apixaban, were used. Clots were prepared from the blood of healthy human donors and subsequently exposed to alteplase treatment. Apixaban and alteplase were used in clinically relevant concentrations. Clot lysis in the static model was determined both by clot weight and spectrophotometric determination of RBC release. Clot lysis in the flow model was determined by measuring recanalization time, clot length and spectrophotometric determination of RBC release. In the static model, clots without apixaban; compared to those with apixaban had alteplase-induced mass loss 54 ± 8% vs. 53 ± 8%, p = 1.00; RBC release 0.14 ± 0.04 vs. 0.12 ± 0.04, p = 0.14, respectively. Very similar results were obtained if plasma was used instead of physiological buffered saline as the incubation medium. In the flow model, clot lysis without apixaban; compared to those with apixaban was as follows: recanalization time 107 ± 46 min vs. 127 ± 31 min, p = 1.00; recanalization frequency 90 ± 22% vs. 90 ± 22%, p = 1.00; clot volume reduction 32 ± 15% vs. 34 ± 10%, p = 1.00; RBC release 0.029 ± 0.007 vs. 0.022 ± 0.007, p = 0.16, respectively. Apixaban had no positive effect on alteplase-induced thrombolysis in both the in vitro static and flow models. Our data support current clinical practice, such that thrombolysis is contraindicated in stroke treatment for patients who have been treated with anticoagulants.
Application of a New Statistical Model for the Description of Solid Fuel Decomposition in the Analysis of Artemisia apiacea Pyrolysis
Authors: Gu Tianbao , Berning Torsten , Yin Chungen 
Published: September 2021

Pyrolysis, one of the key thermochemical conversion technologies, is very promising to obtain char, oil and combustible gases from solid fuels. Kinetic modeling is a crucial method for the prediction of the solid conversion rate and analysis of the pyrolysis process. We recently developed a new statistical model for the universal description of solid fuel decomposition, which shows great potential in studying solid fuel pyrolysis. This paper demonstrates three essential applications of this new model in the analysis of Artemisia apiacea pyrolysis, i.e., identification of the conversion rate peak position, determination of the reaction mechanism, and evaluation of the kinetics. The results of the first application show a very good agreement with the experimental data. From the second application, the 3D diffusion-Jander reaction model is considered as the most suitable reaction mechanism for the description of Artemisia stem pyrolysis. The third application evaluates the kinetics of Artemisia stem pyrolysis. The evaluated kinetics vary with the conversion degree and heating rates, in which the activation energies and pre-exponential factors (i.e., lnA vs. Ea) show a linear relationship, regardless of the conversion and heating rates. Moreover, the prediction of the conversion rate using the obtained kinetics shows an excellent fit with the experimental data.
Bioaccumulation of Chromium(III) from Aqueous Solutions of a Leather Wastewater Treatment Plant by Saccharomyces cerevisiae Yeast
Authors: Janković Patrizia , Spinosi Renos , Bacardit Anna 
Published: September 2021

With many industries discharging heavy metals into natural water resources, heavy metals have been found to accumulate in various living organisms which can ultimately threaten human life and pose a big threat to the environment. Thus, in the pursuit of a solution to the above mentioned problem, bioaccumulation has emerged as an interesting option for the removal of heavy metals from wastewater. In this paper, the effectiveness of the yeast Saccharomyces cerevisiae in the bioaccumulation of Cr3+ has been tested. Also, different factors influencing Cr3+ uptake have been discussed. This work has demonstrated that Saccharomyces cerevisiae is an effective Cr3+ biosorbent for tannery wastewater. The conditions of use of this yeast to achieve optimal chromium (III) absorption are: i) when a growth of the biosorbent equivalent to a similar concentration of Cr3+ is obtained, which contains the residual water that needs to be treated; ii) the smaller the biosorbent is the better the biosorption; iii) the uptake of Cr3+ is more efficient when no extra growth medium is added to the wastewater; iv) the longer the exposure period of the yeast to Cr3+ , the bigger the Cr3+ reduction. Since Saccharomyces cerevisiae is an inexpensive, readily available source of biomass, this discovery could be of great use for a low-budget and efficient wastewater treatment system
PENDIDIKAN KESEHATAN MENGENAI PERUBAHAN YANG TERJADI PADA PEREMPUAN MENOPAUSE DAN PENGELOLAANNYA
Authors: Wardani Desy Ayu , Mukaromah Siti 
Published: September 2021

Menopause adalah fase alamiah yang akan dialami oleh setiap wanita yang biasanya terjadi diantara usia 40 tahun, sekitar usia 40-45 tahun. Menopause merupakan kondisi akhir proses biologis yang menandai berakhirnya masa subur seorang wanita. Kondisi ini menstruasi telah berhenti dalam 1 tahun yang akan berdampak pada konsekuensi kesehatan baik fisik maupun psikis dan angka harapan hidup. Keluhan fisik dan psikologis dirasakan sekitar setahun atau dua tahun setelah masa menstruasi. Keluhan fisik yang timbul diantaranya perasaan panas (hot flushes), keringat berlebihan pada malam hari, insomnia, kekeringan pada vagina, sakit dan nyeri pada persendian, berat badan bertambah. Keluhan psikis diantaranya cemas, emosi yang labil, daya ingat menurun, sulit berkonsentrasi, sulit mengambil keputusan dan merasa tidak berharga. Kegiatan Pendidikan kesehatan (penyuluhan) kesehatan mengenai perubahan – perubahan yang terjadi selama masa menopause dan cara pengelolaannya ini ditujukan pada perempuan dewasa akhir dan perempuan yang sudah menopause RT 41 Kelurahan Loa Bahu Kecamatan Sungai Kunjang Kota Samarinda. Sebanyak kurang lebih 25 peserta yang terlibat dalam kegiatan ini. Hasil dari penilaian kuesioner menunjukkan bahwa nilai pengetahuan peserta terdapat perbedaan sebelum dan sesudah diberikan pendidikan kesehatan mengenai perubahan yang terjadi saat menopause dan pengelolaannya yang dibuktikan dengan terjadi peningkatan nilai pengetahuan pada hampir semua peserta
Manifestaciones cardiovasculares asociadas a enfermedad por COVID – 19
Authors: García Archila Ricardo Andrés 
Published: September 2021

El COVID-19 es una infección viral producida por el SARS-CoV-2, afectando principalmente las vías respiratorias, sin embargo, se han estudiado otros órganos afectados, entre ellos el sistema cardiovascular. OBJETIVO: describir las principales manifestaciones cardiovasculares en los pacientes con enfermedad COVID-19 e identificar los factores de riesgo relacionados con mayor frecuencia a complicaciones cardiovasculares en enfermedad por COVID-19. MÉTODO: se realizó una revisión sistemática de distintas fuentes médicas incluyendo la información más actualizada. RESULTADOS: las principales manifestaciones cardiacas en pacientes con COVID-19 encontradas fueron miocarditis, insuficiencia cardiaca descompensada, síndrome coronario agudo, arritmias y eventos tromboembólicos, además, los factores de riesgo relacionados con mayor frecuencia a complicación cardiovascular en COVID-19 fueron el sexo masculino, edad avanzada y enfermedad cardiovascular preexistente, como hipertensión arterial e insuficiencia cardiaca. CONCLUSIÓN: las manifestaciones cardiacas fueron evidentes, teniendo una repercusión desfavorable en el pronóstico, por lo que una evaluación cardiológica es fundamental en todo paciente con COVID-19.
Caracterización clínica, tomográfica, función respiratoria y pruebas de laboratorio de pacientes con diagnóstico de SARS-CoV-2
Authors: Sipaque De León Rocío María Celeste 
Published: September 2021

OBJETIVO: describir las características clínicas, tomográficas, función respiratoria y pruebas de laboratorio de los pacientes con diagnóstico de SARS-CoV-2. MÉTODO: estudio descriptivo retrospectivo de los pacientes ingresados al servicio del área respiratoria en el Centro Médico y Hospital El Pilar de Guatemala con diagnóstico de Sars-COV-2 durante los meses de junio de 2020 a marzo del 2021, con una muestra de 61 personas evaluadas. RESULTADOS: de 61 expedientes revisados con diagnóstico SARS-CoV-2 de los cuales, el sexo más afectado fue masculino con un 75% (46 pacientes) y el sexo femenino 25% (15 pacientes), el grupo etario más afectado fueron las personas de 46-55 años con un 33% (20 pacientes). La tres manifestaciones clínicas más frecuentes fue disnea con un 75% (46 pacientes) seguido de fiebre en un 67% (41 pacientes), tos en un 66% (40 pacientes), y en los hallazgos tomográficos tuvo predominio el patrón vidrio esmerilado 47% (29 pacientes), seguido de un patrón alveolar difuso con un 26% (16 pacientes), consolidación 23% (14 pacientes), con frecuente afectación bilateral en un 70% (43 pacientes). CONCLUSIÓN: los pacientes recuperados por diagnóstico de SARS-CoV-2 mostraron una función respiratoria alterada. Las pruebas de función respiratoria que fueron afectadas fue el patrón espirométrico sugerente a restricción con un 41% (25 pacientes), una difusión de monóxido de carbono con disminución el 26% (13 pacientes) y una restricción pulmonar en la pletismografía 20% (9 pacientes).
Impact of COVID-19 on Mental Health of Adults with Autism in India
Authors: Javed Amaan , Roy Ritwika 
Published: September 2021

Background:
This study focuses on the direct and indirect implications of the COVID-19 pandemic on adults with Autism in India. This study took into account the social isolation during the global pandemic in 2020 and its effect on the emotional well-being of the community.
Methods:
We designed a survey involving Indian residents. Part I involved questionnaires for different cohorts: 1) educated, 2) employed and 3) unemployed. The questions were based on proposed life models to maintain the heterogeneity according to the preferences of the target group. Part II of involved online interviews conducted in English. Qualitative and quantitative analyses were performed.
Findings:
The analyses of participants’ responses (N=10) stipulated that the impact of the COVID-19 pandemic on autistic people's mental health has been variable. Participants encountered both positive and negative emotions. Factors such as disrupted schedules, fear of job loss, poor domestic support system and inconsistency in transition were important. These were associated with development of new or worsening of pre-existing psychological as well as behavioural conditions including depression, anxiety, panic attacks and high-stress levels. At the same time, reduced interactions with decreased social insistence led to an improvement for some participants.
Interpretation:
Our results illustrate the deterioration of mental health and well-being for Autistic adults due to the impact of the COVID-19 pandemic. These findings emphasise the need for the development of innovative approaches and investment in the creation of support systems to address mental distress in this population.
Contribution to the "Atlas of the Russian Flora": Twelve local floras of European Russia
Authors: Seregin Alexey P. 
Published: September 2021

The purpose of this dataset is to deliver to a wider audience in the form of GBIF-mediated data vast floristic materials collected by the author across various localities of European Russia from 2001-2019 (Arkhangelsk, Tver, Vladimir, Tula, Lipetsk, Voronezh Oblasts, Krasnodar Krai, City of Moscow and Komi Republic). Taxonomic data on vascular plants for ten locations were mobilised from the papers and technical reports published in Russian and standardised. Floristic treatments for two locations (Yasnaya Polyana and Tsaritsyno) have never been published before.
The newly-prepared dataset includes 5,309 species records, i.e. one species record per each local flora. These are either native or alien (fully naturalised and casual) species. All records within one local flora have the same centroid coordinates and coordinate uncertainty in metres. Floristic inventories from the following locations were mobilised: 01. Ustya, Arkhangelsk Oblast (543 species, 1,500 km2); 02. Zaseki, Tula Oblast (593 species, 60 km2); 03. Polibino, Lipetsk Oblast (553 species, 70 km2); 04. Khrenovoye, Voronezh Oblast (665 species, 200 km2); 05. Troyeruchitsa, Tver Oblast (501 species, 10 km2); 06. Man-Pupu-Ner, Komi Republic (182 species, ca. 300 km2); 07. Middle Lyaga, Komi Republic (143 species, ca. 300 km2); 08. Utrish, Krasnodar Krai (933 species, 195 km2); 09. Yasnaya Polyana, Tula Oblast (236 species, 2.2 km2); 10. Bogolyubovsky Lug, Vladimir Oblast (289 species, 1.7 km2); 11. Tsaritsyno, City of Moscow (359 species, 5.3 km2); 12. Patakino, Vladimir Oblast (312 species, 1.1 km2). According to the GBIF taxonomic backbone, the dataset covers 1,806 species, 669 genera and 127 families of tracheophytes.
Lien ne tient plus
Authors: Iucksch Marlène 
Published: September 2021

On s’interroge dans ce texte sur la nature des liens qui attachent ou relient l’enfant à sa famille d’origine. Existe-t-il un lien ou des liens ? L’enfant qui va à l’école est-il séparé douloureusement de sa famille ? N’est-ce pas une séparation nécessaire permettant à l’enfant de se préparer peu à peu à quitter le lieu familial ? Un cas de mère en situation de grande précarité sociale, sans papiers et toxicomane, est ensuite présenté. Les équipes de professionnels s’occupant de l’enfant ballotté de lieu en lieu, régulièrement délaissé par une mère qui apparaît néanmoins aimante, n’arriveront que très difficilement à opérer un placement. Il est rappelé dans la conclusion que F. Dolto disait : « Le traumatisme ne vient pas de la séparation en soi mais de l’impossibilité d’une séparation de la mère à l’enfant. »
Interrogations sur la fonction paternelle dans l'accueil familial
Authors: de Chassey Jutta 
Published: September 2021

Avec en tête la question du « père », l’auteur débute l’article par un rappel instructif sur la législation concernant le dispositif « Placement familial » à l’Aide sociale à l’enfance, ainsi que sur la définition de la place du père dans une famille. Puis elle présente quelques réflexions qu’elle a obtenues au cours des entretiens de recrutement et dans le suivi de l’assistante familiale et de la place de son conjoint. Point important de conclusion : « Envisager le travail en placement familial autrement qu’en termes “d’assistance maternelle” amène à penser que la famille d’accueil représente en quelque sorte le système familial en tant que tel sous la forme d’une famille particulière, et c’est ça qui étaye la trajectoire œdipienne de l’enfant accueilli… On pourrait dire que le mari de l’assistante maternelle, avant d’être père d’accueil est d’abord “père de famille”, autrement dit qu’il est structurellement père (d’accueil) dans la mesure où il est père de famille. »
Vertical Differentiation, Uncertainty, Product R & D and Policy Instruments in a North-South Duopoly
Authors: Berthoumieu Julien , Lamani Viola 
Published: September 2021

Cet article analyse l’effet de plusieurs instruments de politique commerciale sur la Recherche et Développement (R & D) de produits à travers un modèle de duopole Nord-Sud dans lequel une firme du Nord concurrence une firme du Sud par les prix sur les deux marchés. La firme du Nord investit en R & D de produits en raison d’un désavantage compétitif par rapport à la firme du Sud qui bénéficie d’un coût de travail plus faible. Le résultat de la R & D est incertain. Si l’investissement se traduit par un succès, il y a de la différentiation verticale sur les deux marchés. Le gouvernement du pays du Nord est le seul à pouvoir mettre en place les instruments suivants : un droit de douane, un quota d’importation ou un standard de qualité. Les résultats montrent que les dépenses en R & D de la firme du Nord augmentent avec chacun de ces instruments à l’exception du quota d’importation. L’article fournit également une analyse de bien-être pour comparer les effets de ces mesures. Les résultats des simulations numériques suggèrent que le gouvernement du pays du Nord est incité à mettre en place un droit de douane, excepté lorsque la préférence du consommateur pour la qualité du produit est élevée. Dans ce cas, l’instrument privilégié serait le standard de qualité.
La puissance par l’image
Authors: Paquin Stéphane 
Published: September 2021

Internet et les médias sociaux ont profondément transformé l’exercice du métier de diplomate, qui doit désormais maîtriser l’art de la diplomatie numérique, devenir un expert de la « twiplomatie » et des big data tout en évitant l’écueil des fake news .
La puissance par l’image
Authors: Guilbaud Auriane 
Published: September 2021

Les ONG sont-elles une ressource ou une contrainte pour les États ? Imbriquées dans la diplomatie publique gouvernementale, elles peuvent la concurrencer ou l’influencer. Dans tous les cas, leur expertise, leur capacité de mobilisation de l’opinion publique et leur fonction de légitimation sont au cœur de leurs interactions avec les États.
La puissance par l’image
Authors: Oudet Benjamin 
Published: September 2021

Comment articuler renseignement et diplomatie publique ? Tout semble les opposer : si l’un est ouvert, l’autre est secret. Mais selon des modalités différentes, ne sont-ils pas les deux composantes des stratégies d’influence menées par les États, le premier n’étant que le miroir de la seconde ?
Aux origines de la complexité économique : place de la créativité dans la tradition économique autrichienne
Authors: Gloria Sandye 
Published: September 2021

L’objectif de cet article est d’identifier les ingrédients indispensables pour permettre la prise en compte du phénomène de la créativité dans l’analyse économique appréhendé des deux points de vue de l’individu et du système. Pour répondre à cette question, nous adoptons une approche d’histoire de l’analyse économique et plus précisément il s’agira d’examiner la spécificité d’une approche où la créativité occupe une place théorique centrale : la tradition économique autrichienne. Quels sont les éléments spécifiques à cette approche qui permettent la prise en compte du phénomène de la créativité ? Pour affiner la réponse, nous confronterons les divers courants qui coexistent au sein même de la tradition économique autrichienne et dans lesquels la place de la créativité est inégale. Le schéma conceptuel de la complexité économique offre selon nous la possibilité de redéfinir en un tout cohérent l’ensemble des éléments précédemment identifiés.Classification JEL : B13, B25, B41, B53.