bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Fate of Periprosthetic Joint Infection Following Megaprosthesis Reconstruction
Authors: Sukhonthamarn Kamolsak , Tan Timothy L. , Strony John , Brown Scot , Nazarian David , Parvizi Javad 
Published: November 2021

Background:
A megaprosthesis may be used for reconstruction in patients with massive bone loss or a periprosthetic fracture. Periprosthetic joint infection (PJI) may occur after a megaprosthesis reconstruction and may pose a major challenge. The outcomes of managing PJI in patients with a megaprosthesis is relatively unclear. The aim of this study was to investigate the clinical course and outcomes of PJI in patients with a megaprosthesis in place.

Methods:
From a total of 219 patients who underwent megaprosthesis replacement for non-oncologic conditions, 38 (17.4%) developed subsequent PJI. A retrospective review of the medical record was performed to ascertain the course of the PJI and treatment outcomes. Kaplan-Meier analysis was performed to evaluate the survival function, and the log-rank test was used to assess differences in outcome measures.

Results:
The surgical management of 33 patients with PJI included debridement, antibiotics, and implant retention (DAIR) (82%), consisting of DAIR with modular component exchange (19 patients) and DAIR without component exchange (8 patients); 2-stage exchange arthroplasty (9%); resection arthroplasty (6%); and a single-stage revision arthroplasty (3%). The Kaplan-Meier survivorship analysis demonstrated that the overall survival rate was 65.1% at 2 years. The mortality rate was 15%, with many patients undergoing salvage procedures including amputation (18%), arthrodesis (6%), and resection arthroplasty (6%).

Conclusions:
The rate of PJI after megaprosthesis reconstruction, 17% in this study, appears to be very high. The management of PJI in these patients is challenging, with 1 of 3 patients undergoing failed treatment. Despite the limited options available, DAIR seems to be an appropriate treatment strategy for some of these patients. Further data on a larger cohort are needed to assess the success of various surgical procedures and predictors of failure in this challenging patient population.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Graft-Augmented Repair of Irreparable Massive Rotator Cuff Tears with Latissimus Dorsi Transfer to Treat Pseudoparesis
Authors: Imai Shinji 
Published: November 2021

Background:
Irreparable massive rotator cuff tears are characterized by a poor prognosis with high failure rates following repair. Numerous strategies, such as partial repair, graft interposition, latissimus dorsi (LD) transfer, balloon arthroplasty, and superior capsular reconstruction, have been proposed. We have adopted a graft-augmented LD-transfer procedure, in which partial repair, graft interposition, and LD transfer are performed simultaneously.

Methods:
Thirty-nine patients underwent the graft-augmented LD-transfer procedure using autologous fascia lata from 2007 to 2016. All patients underwent a 5-year assessment at a mean (and standard deviation) of 54.8 ± 3.5 months. Of 20 patients with a history of >10 years, 14 underwent a 10-year assessment at a mean of 112.6 ± 5.6 months. To characterize the therapeutic effects of the procedure, the patients were divided into 3 groups according to the tear pattern: superior-posterior tears (Group A), superior-anterior tears (Group B), and global tears (Group C).

Results:
The overall mean Constant-Murley score improved from 33.8 ± 5.3 preoperatively to 63.1 ± 9.4 at the 5-year assessment (p < 0.001). The overall mean active anterior elevation (AE) improved from 57.3° ± 13.2° preoperatively to 131.3° ± 18.2° at 5 years (p < 0.001). Preoperatively, AE was significantly different between Groups A and C (p < 0.001) and between Groups B and C (p < 0.001), reflecting the difference in cuff tear patterns. Postoperatively, AE was significantly higher in Group A than in Groups B (p < 0.001) and C (p < 0.001). The present study also showed that AE was electromyographically synchronized to the contraction of the transferred LD. The transferred LD was kinetically more potent at a slower speed, but it was easier to exhaust, than the native rotator cuff. Osteoarthritis progression was radiographically found to occur during the first 5 years.

Conclusions:
The graft-augmented LD-transfer procedure may be a treatment option for massive rotator cuff tears, especially for active patients who are <60 years old.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Activity Level and Sport Type in Adolescents Correlate with the Development of Cam Morphology
Authors: Westermann Robert W. , Scott Elizabeth J. , Schaver Andrew L. , Schneider Anthony , Glass Natalie A. , Levy Steven M. , Willey Michael C. 
Published: November 2021

Background:
The purpose of this study was to evaluate the influence of the volume and type of sport on the development of cam-type femoroacetabular impingement and acetabular dysplasia.

Methods:
The Physical Activity Questionnaire for Adolescents (PAQ-A) was administered to Iowa Bone Development Study participants at the age of 17 years to identify those who had participated in at least 2 seasons of high school interscholastic sports. Based on relative peak strain and ground reaction forces, subjects were grouped as power sport athletes (basketball, cheerleading, football, gymnastics, soccer, and volleyball), non-power sport athletes (wrestling, baseball, cross-country or track and field, softball, or tennis), or non-athletes. Using anteroposterior views of the left hip formatted from dual x-ray absorptiometry (DXA) scans, the alpha angle, head-neck offset ratio (HNOR), and lateral center-edge angle (LCEA) were evaluated longitudinally at the ages of 17, 19, and 23 years. Logistic regression was used to evaluate the odds of hip cam morphology (alpha angle >55° and/or HNOR <0.17) or acetabular dysplasia (LCEA <24°) at the age of 23 years in all athlete groups. The relationships between physical activity level and hip measures (alpha angle, HNOR, and LCEA) from the ages of 17 to 23 years were examined using linear mixed models adjusted for sex.

Results:
Compared with non-athletes at the age of 23 years, power sport athletes had significantly greater odds of cam morphology according to the alpha angle (odds ratio [OR], 2.93 [95% confidence interval (CI), 1.02 to 8.41]; p = 0.046) and HNOR (OR, 1.91 [95% CI, 1.01 to 3.60]; p = 0.047), but not greater odds of acetabular dysplasia (p > 0.05). There were no significant differences in the odds of cam morphology or acetabular dysplasia in non-power sport athletes compared with non-athletes (all p > 0.05). Higher physical activity levels were significantly associated with an increase in the alpha angle (beta and standard error, 0.77° ± 0.30°; p = 0.011) and a decrease in the HNOR (−0.003 ± 0.001; p = 0.003), but not the LCEA (−0.05 ± 0.15; p = 0.744).

Conclusions:
A higher volume of physical activity and participation in sports with higher peak strain and ground reaction forces during the process of skeletal maturation may increase the risk of developing cam morphology during late adolescence.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Multivariate Versus Univariate Spectrum Analysis of Dentine Sialophosphoprotein (DSPP) for Root Resorption Prediction: A Clinical Trial
Authors: Zain Mohd Norzaliman Mohd , Yu Zalhan Md , Basri Katrul Nadia , Yazid Farinawati , Teh Yong Xian , Ashari Asma , Ariffin Shahrul Hisham Zainal , Wahab Rohaya Megat Abdul 
Published: November 2021

Abstract
Background: A force applied during orthodontic treatment induces inflammation to root area and lead to root resorption known as Orthodontically Induced Inflammatory Root Resorption (OIIRR). Dentine sialophosphoprotein (DSPP) is one of the most abundant non-collagenous protein in dentine that was released into gingival crevicular fluid (GCF) during OIIRR. The aim of this research is to compare DSPP detection using the univariate and multivariate analysis in predicting classification level of root resorption. Methods: The subjects for this study consisted of 30 patients in 3 group classified as normal, mild and severe groups of OIIRR. The GCF samples were taken from upper permanent central incisors in the normal and mild group while the upper primary second molars in the severe group. The DSPP qualitative detection limit was determined by analyzing the whole absorption spectrum utilizing multivariate analysis embedded with different preprocessing method. The multivariate analysis represents the multi-wavelength spectrum while univariate analyzes the absorption of a single wavelength. Results: The results showed that the multivariate analysis technique using Partial Least Square-Discriminate Analysis (PLS-DA) with the preprocess method has successfully improved in classification prediction for the normal and mild group at 0.88 percent accuracy. The multivariate using PLS-DA algorithm with Mean Center preprocess method was able to predict normal and mild tooth resorption classes better than the univariate analysis. The classification parameters have improved in term of the specificity, precision and accuracy. Conclusion: Therefore, the multivariate analysis helps to predict an early detection of tooth resorption complimenting the sensitivity of the univariate analysis.
Cortex-independent open-loop control of a voluntary orofacial motor action
Authors: Elbaz Michael , Demers Maxime , Kleinfeld David , Ethier Christian , Deschenes Martin 
Published: November 2021

Abstract
Whether using our eyes or our hands, we interact with our environment through mobile sensors. The efficient use of these sensory organs implies the ability to track their position; otherwise, perceptual stability and prehension would be profoundly impeded. The nervous system may be informed about the position of a sensory organ via two complementary feedback mechanisms: peripheral reafference (external, sensory feedback) and efference copy (internal feedback). Yet, the potential contributions of these mechanisms remain largely unexplored. By training rats to place their vibrissae within a predetermined angular range without contact, a task that depends on knowledge of vibrissa position relative to their face, we found that peripheral reafference is not required. The presence of motor cortex is not required either, even in the absence of peripheral reafference. On the other hand, the red nucleus, which receives descending inputs from motor cortex and the cerebellum and projects to facial motoneurons, is critical for the execution of the vibrissa task. All told, our results demonstrate the existence of an open-loop control by an internal model that is sufficient to drive voluntary motion. The internal model is independent of motor cortex and likely contains the cerebellum and associated nuclei.
Practical N-Alkylation via Homogeneous Iridium-Catalyzed Direct Reductive Amination
Authors: Wang Jing , Yang Xiongyu , Liu Jingwen , Gao Guorui , Huang Haizhou , Chang Mingxin 
Published: November 2021

Abstract
Direct reductive amination (DRA) is one of the most efficient methods for amine synthesis. Herein we report a practical homogeneous DRA procedure utilizing iridium catalysis. Applying simple, readily available and inexpensive PPh3 and alike ligands at as low as 0.003 mol%, aldehydes and ketones reductively coupled with primary and secondary amines to efficiently form structurally and functionally diverse amine products, including a set of drugs and their late-stage manipulation. The reaction conditions were exceptionally mild and additive-free, and they tolerated oxygen, moisture, polar protic groups and multiple other functional groups. For targeted products, this methodology is versatile and could offer multiple synthetic routes in regard to the selection of starting materials. The 10 gram-scale synthesis further demonstrated the potential and promise of this procedure in practical amine synthesis.
The Development of Support for People Following COVID-19 Infection in Kyrgyzstan: Survey Study of Patients and Clinical Workers
Authors: Taalaibekova Aijan , Oleinik Alena , Magdieva Kamila , Mirzalieva Gulzada , Yusuf Zainab K. , Mademilov Maamed , Akylbekov Azamat , Jones Amy V. , Miah Ruhme B. , Malcolm Dominic , Barton Andy , Sooronbaev Talant , Singh Sally J. , Orme Mark W. 
Published: November 2021

Abstract
Background: After the acute period from SARS-CoV-2 infection, many COVID-19 survivors continue to have ongoing symptoms. There is a need to render assistance to such COVID-19 survivors in Kyrgyzstan but it is unclear how support should be designed. This study aimed to examine what this support should look like, specifically the persisting post-COVID symptoms, views on the optimal timing, suitable delivery methods, content of the support, and obstacles to implementation. Methods: This study was conducted by using two cross-sectional online surveys in the Russian language. The first group included clinical workers of various specialties who worked in the places of treatment for patients with COVID-19. The second group consisted of patients aged ≥18 years who had recovered from COVID-19 who were recruited from family medicine centers using the database of COVID-19 survivors. The survey was conducted anonymously and voluntarily, and consisted of 16 questions. Results: 85 clinical workers and 132 COVID-19 survivors took part in the survey. COVID-19 survivors reported they would be willing to devote 1-3 sessions per a week (84%) with a duration of no more than 1 hour (90%) to post-COVID interventions. Respondents identified the Internet (43%) and separate smartphone applications (42%) as the best media via which to receive support at home. The greatest barrier to accepting help was the risk of re-infection (43%). According to clinical workers, the main goal of post-COVID-19 support should be the amelioration of breathing problems (70%), increased physical exercise (57%) and elements of psychological support (57%). Clinical workers reported that support should begin during treatment for COVID-19 (65%), or immediately after returning from the hospital (59%). Respondents stated that it would be better to carry out support at home via video conference (65%), or by means of telephone calls (47%). The cost of treatment (47%) and the individual’s employment at work (43%) were deemed potential barriers to COVID-19 survivors participating in support interventions.Conclusions: Clinical workers and COVID-19 survivors deemed post-COVID-19 support necessary. Our results will directly inform the development and delivery of post-COVID support interventions in Kyrgyzstan and Central Asia, in combination with the views and needs identified directly from people with persisting post-COVID symptoms.
Safety and Efficacy of Vacuum Bottle Plus Catheter for Drainage of Iatrogenic Pneumothorax
Authors: Chen Shih-Yu , Kuo Yao-Wen , Ho Chao-Chi , Wu Huey-Dong , Wang Hao-Chien 
Published: November 2021

Abstract
Iatrogenic pneumothorax is common after thoracic procedures. For pneumothorax larger than 15%, simple aspiration is suggested. This clinical trial (NCT03724721) assessed the safety and efficacy of vacuum bottle plus non-tunneled catheter air drainage, which has long been performed in many institutions. From August 2018 to February 2020, patients older than 20 years of age who developed iatrogenic pneumothorax were prospectively enrolled. Totally 21 patients underwent vacuum bottle plus catheter drainage. The median size of pneumothorax was 19.6%, as measured by Rhea’s method. Of the 21 patients, 15 had successful air drainage, and the remaining 6 patients required subsequent pigtail placement. The end-expiratory intrapleural pressure of all patients remained less than -20 cmH2O during drainage. The median duration of hospitalization was 2 (interquartile range [IQR], 1-4) days. No procedure-related complication was observed. A retrospective analysis of patients who received conservative treatment showed that the median duration of hospitalization was longer in patients with larger pneumothorax (1 day vs. 5 days [IQR, 1-1 day vs. 3-7 days]). This study showed that vacuum bottle plus catheter drainage of iatrogenic pneumothorax is a safe and efficient procedure. It is recommended as initial management of stable iatrogenic pneumothorax with size larger than 15%.
Welding Procedure Qualification Record (WPQR) for Welds Fabricated At Proximity
Authors: Bhardwaj Sachin , Ratnayake R.M. Chandima 
Published: November 2021

Abstract
Maintaining minimum allowable distance between proximity welds has always been considered a subject of debate between design engineers, welding engineers/inspectors and fabricators/engineering contractors. The scattered nature of guidelines available in welding codes and standards for maintain minimum allowable distance pose a significant challenge in the welding procedure and inspection criteria development process. This is especially critical for complex welded joints on submerged sections of offshore structures, in compact layouts/branched connections of topside piping components, and on topside structural joints (depending on the complexity). This manuscript presents the findings of an experimental study that was performed by fabricating two girth welds at a proximity on an S355 steel tubular section having diameter of 219.1 mm and thickness of 8.18 mm. Proximity girth welds were fabricated on S355 tubular sections at three different distances between their weld toe as 5, 10 & 15mm respectively using two different welding procedures. Welding procedure qualification record (WPQR) was performed, and all prescribed mechanical tests were recorded as per NORSOK M-101, a structural steel fabrication code. Although all results from mechanical test met minimum specified values as defined in the NORSOK code, research findings revealed noticeable difference in Charpy and hardness values for proximity region between adjacent welds. Considerable changes in final microstructure morphology were observed between proximity welds due to successive thermal cycles. These observations can form basis for future welding procedure qualification of critical welded joints, especially for proximity welds on critical welded joints of offshore structures and welds fabricated during replacement/repair procedures in compact piping layouts.
Evaluatiing the Effects of HIV Self-testing used Professional Rapid Test Kits among MSM in Some Areas of China.
Authors: He Xiaoxia , Ren Yanan , Ma Zhonghui , Guo Wenhui , Jin Cong , Xing Wenge 
Published: November 2021

Abstract
With rapid expanding of HIV self-testing (HIVST) among unprofessional people has many unknown hidden dangers. This research for the first to survey the feasibility of urine, oral mucosal transudate (OMT) and finger blood rapid HIV testing kits were used for HIVST by non-professionals MSM in China. Total 274 valid questionnaires were received from 313 MSM participants, including 263 completed urine HIVST, 61 completed OMT HIVST and 17 completed blood HIVST. The average age of participants was under 30, about 80% were unmarried, more than 80% with an education level above Grade 9 but more than 50% people had never heard of the rapid HIV test. There were significant differences in the key information understanding accuracy between HIVST. The accuracy rates were 18.0–80.6%. When the HIVST result was positive, more than 80% chose to seek confirmation. When the test was negative, 60.5% (159/263) participants of urine self-test and 32.8% (20/61) of OMT self-test chose regular retesting. When the test was ineffective, more than 80% chose to retest. In addition, 54.1% of the 146 voluntary participants to accept blood HIVST, followed by 15.8% accept blood and urine HIVST and 14.4% accept only urine HIVST. The main reason for choosing blood HIVST was "accuracy", while the main reason for choosing urine HIVST was "convenience". This findings lays a scientific theoretical basis for further carring out HIVST in China.
Multi-level Memristors based on Two-dimensional Electron Gases in Oxide Heterostructures for High Precision Neuromorphic Computing
Authors: Lee Sunwoo , Jeon Jaeyoung , Eom Kitae , Jeong Chaehwa , Yang Yongsoo , Park Ji-Yong , Eom Chang-Beom , Lee Hyungwoo 
Published: November 2021

Abstract
Memristors are essential elements for hardware implementation of artificial neural networks. The key functionality of the memristors is to realize multiple non-volatile conductance states with high precision. However, the variation of device conductance limits the number of allowed states. Since actual data for neural network training inherently have a non-uniform distribution, the insufficient number of conductance states and the resultant inaccurate weight quantization may generate significant errors in the memristor-based computation. Herein, we demonstrate a multi-level memristor based on two-dimensional electron gas in a Pt/LaAlO3/SrTiO3 heterostructure. By redistributing oxygen vacancies, we precisely controlled the tunneling conductance of the device, achieving multiple conductance states (more than 27). The multi-level switching capability and the high retention performance allow us to implement a variance-aware weight quantization (VAQ), designed for improved computing accuracy. We verify that the VAQ provides greater accuracy in image classification process, as compared to conventional uniform quantization. These results provide valuable insight into developing high-precision multi-bit memristors for practical neuromorphic processors.
Identifying Stage-Associated Hub Genes in Bladder Cancer via Weighted Gene Co-Expression Network and Robust Rank Aggregation Analyses
Authors: Feng Fu , Zhong Yu-Xiang , Huang Jian-Hua , Lin Fu-Xiang , Zhao Peng-Peng , Mai Yuan , Wei Wei , Zhu Hua-Cai , Xu Zhan-Ping 
Published: November 2021

Abstract
Background

Bladder cancer (BC) is among the most frequent cancers globally. Although substantial efforts have been put to understand its pathogenesis, its underlying molecular mechanisms have not been fully elucidated.
Methods

The Robust Rank Aggregation (RRA) approach was adopted to integrate four eligible bladder urothelial carcinoma (BLCA) microarray datasets from the GEO. Differentially expressed genes (DEGs) sets were identified between tumor samples and equivalent healthy samples. We constructed gene co-expression networks using WGCNA to explore the alleged relationship between BC clinical characteristics and gene sets, as well as to identify hub genes. We also incorporated the WGCNA and RRA to screen DEGs.
Results

CDH11, COL6A3, EDNRA and SERPINF1 were selected from the key module and validated. Based on the results, significant downregulation of the hub genes occurred during the early stages of BC. Moreover, Receiver operating characteristics (ROC) curves and Kaplan-Meier (KM) plots showed that the genes exhibited favorable diagnostic and prognostic value for BC. Based on GSEA for single hub gene, all the genes were closely linked to BC cell proliferation.
Conclusions

These results offer unique insight into the pathogenesis of BC and recognize CDH11, COL6A3, EDNRA and SERPINF1 as potential biomarkers with diagnostic and prognostic roles in BC.