bluuebunny/crossref_metadata_2025_split huggingface dataset:
BER Illusion Methodology: A Novel, Open Sourced and Scalable Approach to Troubleshooting High Radix Photonics Interconnects in a Modern Hyperscale Datacenter
Authors: Rao Shreyas , Chakravarty Abhijit , Jani Dharmesh 
Published: November 2021

Abstract
Facebook Datacenter consists of a large number of servers that run diverse Facebook services aggregated to serve any given user request. To allow this aggregation, servers have to interact with each other via different traffic flows which are managed by networking fabric. The underlying connection powering this fabric consists of a large number of pluggable optical interconnects and On Board Optical (OBO) modules carrying production data. This connectivity at scale requires fast and reliable detection of the link failures to ensure resolution. In the first generation of the deployments, detection of the link failure was sequential and a slow process. The troubleshoot process was equally tedious as the available tools required characterizing one optical transceiver at a time. Further, the failure analysis also presented a majority of resolution with no failed optics as a root cause resulting in high No Trouble Found (NTF) rate.
In this paper we introduce a novel link failure detection and resolution method that improves on the previous method across three dimensions: faster resolution, reliable troubleshooting and scalable implementation. We introduce BER Illusion Methodology (BIM) that is a highly scalable and resource efficient solution that significantly reduces the time taken to troubleshoot pluggable optical interconnects. This is also scalable to next-gen OBO modules at Facebook datacenters aiming to lower the NTF rate and optimally utilizing the available resources. BIM, which is based on Open Compute Platform (OCP) network switches, can be used to troubleshoot 128 QSFP28, 64 QSFP56 or 32 OBO modules simultaneously in under 30 minutes. The tool is easy to implement and capable of also reporting diagnostics on the transceiver such as Transmitter Power, Transmitter Bias Current, Receiver Power, Case Temperature, Bit Error Rate result per channel, Vendor information and Manufacturing part number. This additional test data report along with true failure indication helps optic suppliers gain confidence and build customer credibility. The open-source nature and the universal applicability of this tool offers possibility for other users to adopt and further customize it for their networking needs.
Interaction of Surface Preparation and Cure-Parameters on the Interface Reliability of Flexible Encapsulation in FHE Applications
Authors: Lall Pradeep , Choudhury Padmanava , Miller Scott 
Published: November 2021

Abstract
Flexible devices, considered to be the next wave of electronics industry, require flexible encapsulation for protection while conforming to flexibility-needs in end applications. The characteristics of flexible electronics is not only reduced production cost but also thinner, lightweight and non-breakable which creates a new form application for the electronic devices. One such application is use to electronic devices in daily environment to monitor the vitals of one’s body. These devices are often expose to dust, sweat and moisture also they are generally subjected to flexing and folding motion which accrues stresses in those devices. These stresses and the harsh environment are often mitigated by using potting compounds, encapsulants to improve their survivability of the devices. In our study, we have chosen five different formulation of encapsulant subjected it various cure profiles to determine the adhesive strength of the various encapsulant. The benchmark peel strength was developed using a FE-model of the AU-biometric band and encapsulant peel strength at experimental conditions were compared to give us the best performing material. This paper includes the sample geometry which consists of five different encapsulants and two different substrate namely, polyimide and pet tested at four different cure schedule while the substrates were cleaned using two different cleaning methods. The encapulants are compared among each other to create a rank for possible future applications in FHE devices.
Property Evolution and Reliability of Underfills Under Sustained High Temperature Storage
Authors: Lall Pradeep , Kasturi Madhu , Wu Haotian , Suhling Jeff , Davis Edward 
Published: November 2021

Abstract
Automotive underhood electronics may be exposed to high temperature in the neighborhood of 100°C–200°C. Property evolution may impact reliability and accuracy of predictive models to assure desired use life. In this paper, evolution of properties of two underfill material properties are studied using DMA (Dynamic Mechanical Analyzer). The underfills are exposed to three different operational temperatures in the range of 100°C to 140°C for the measurements. The dynamic mechanical properties such as storage modulus (E′), loss modulus (E″), tangent delta (tan δ), and respective glass transition temperatures (Tg) are studied using DMA. Study of viscoelastic behavior of underfills is achieved by performing TTS (time-temperature superposition) experiments at 7 discrete frequencies 0.1, 0.21, 0.46, 1, 2.15, 4.64, and 10 Hz using DMA in three-point bend mode. From the selected reference temperatures, the master curves were constructed for storage moduli, loss moduli and tan delta as a function of frequency using TTS results. Using the WLF (Williams-Landel-Ferry) equation, the shift factors as a function of temperature were determined along the frequency axis. The relaxation modulus as a function of temperature and time can be obtained using the master curves of storage and loss moduli. A simple and detailed procedure has been established to find the Prony series constants.
Additively Printed Flexible Temperature Sensor for Wearable Applications
Authors: Lall Pradeep , Jang Hyesoo , Narangaparambil Jinesh , Goyal Kartik , Hill Curtis 
Published: November 2021

Abstract
The flexible sensor has the capability to be mounted on any curved surfaces of applications and be used for portable devices. Additively printed sensors have received attention owing to their compact design and ability of application to non-planar surfaces. Wearable applications require capability of integration into a variety of surfaces with ability to flex, fold, twist and stretch under the stresses of daily motion. There is scarcity of data on the interaction of the process parameters with the realized performance. In addition, there is need for data focused on sensor accuracy, repeatability, and reliability. In this study, experimental analysis on function of the fabricated sensing board is conducted. The temperature sensors are made by direct write printing method with nScrypt printer. A calibration of the sensors has been conducted to confirm that resistance is well related to actual temperature and find TCR (temperature coefficient to resistance). The evolution of resistance has been correlated with the environmental temperature. The sensor hysteresis has been quantified using upswing and downswing of the environmental temperature. In addition, the effect of humidity on the temperature sensor accuracy and performance has been quantified. The effect of a polymide coat on the sensor to prevent humidity effects has also been quantified.
Association between systolic blood pressure course and outcomes after stroke thrombectomy
Authors: Matusevicius Marius , Cooray Charith , Holmin Staffan , Bottai Matteo , Ahmed Niaz 
Published: November 2021

BackgroundSystolic blood pressure (SBP) after endovascular thrombectomy (EVT) for large artery occlusive stroke is dynamic, requiring adaptable early prediction tools for improving outcomes. We investigated if post-EVT SBP course was associated with outcomes.MethodsEVT-treated patients who had a stroke at Karolinska University Hospital, Stockholm, Sweden, were included in the study during 12 February 2018–11 February 2020. SBP was recorded during the first 24 hours after EVT. Primary outcome was functional independence defined by a Modified Rankin Scale score of 0–2 at 3 months. Secondary outcomes were death by 3 months, symptomatic intracranial haemorrhage and any intracranial haemorrhage. Patients with favourable outcomes were used as a reference SBP course in mixed linear effects models and compared with SBP courses of patients with unfavourable outcomes using the empirical best linear unbiased predictor, measuring deviations from the reference SBP course using the random effects. We tested model predictive stability for SBP measurements of only 18, 12 or 6 hours after EVT.Results374 patients were registered, with mean age 71, median NIHSS score of 15, and 53.2% men. Deviating from a linear SBP course starting at 130 mm Hg and decreasing to 123 mm Hg at 24 hours after EVT was associated with lower chances of functional independence (adjusted OR 0.53, 95% CI 0.29 to 0.88, for reaching either 99 or 147 mm Hg at 24 hours after EVT). All SBP course models for the remaining outcomes did not show statistical significance. Functional independence models showed stable predictive values for all time periods.ConclusionDeviating from a linear SBP course was associated with lower chances of 3-month functional independence.
Learning while leading: a realist evaluation of an academic leadership programme
Authors: Li Shelly-Anne , Chen Ruth , Tong X Catherine , Wong Anne K , Chan Teresa M 
Published: November 2021

IntroductionMany academic health centres and universities have implemented leadership development programmes; however, their potential impact in different contexts in healthcare remains unknown. We assessed the impact of an academic leadership development programme on the self-reported leadership activities of faculty leaders in their respective work contexts.MethodsTen faculty leaders who participated in a 10-month leadership development programme between 2017 and 2020 were interviewed. The realist evaluation approach was used to guide deductive content analysis, allowing concepts related to what works for whom, why and when to emerge from the data.ResultsFaculty leaders benefited in different ways depending on the organisational context (eg, culture) in which they reside and their individual contexts (eg, personal aspirations as a leader). Faculty leaders who have minimal mentorship in their leadership role gained an increased sense of community and belongingness with peer leaders and received validation in their personal leadership approach from the programme. Faculty leaders with accessible mentors were more likely than their peers to apply the knowledge they learnt to their work settings. Prolonged engagement among faculty leaders in the 10-month programme fostered continuity of learning and peer support that extended beyond programme completion.ConclusionsThis academic leadership programme included participation of faculty leaders in different contexts, resulted in varying impacts on participants’ learning outcomes, leader self-efficacy and application of acquired knowledge. Faculty administrators should look for programmes with a multitude of learning interfaces to extract knowledge, hone leadership skills and build networks.
Impact of ultrasound-guided erector spinae plane block on outcomes after lumbar spinal fusion: a retrospective propensity score matched study of 242 patients
Authors: Soffin Ellen M , Okano Ichiro , Oezel Lisa , Arzani Artine , Sama Andrew A , Cammisa Frank P , Girardi Federico P , Hughes Alexander P 
Published: November 2021

BackgroundWe evaluated the impact of bilateral ultrasound-guided erector spinae plane blocks on pain and opioid-related outcomes within a standardized care pathway for lumbar fusion.MethodsA retrospective propensity score matched cohort study. Clinical data were extracted from the electronic medical records of patients who underwent lumbar fusion (January 2019–July 2020). Propensity score matching based on common confounders was used to match patients who received or did not receive blocks in a 1:1 ratio. Primary outcomes were Numeric Rating Scale pain scores (0–10) and opioid consumption (morphine equivalent dose) in the first 24 hours after surgery (median (IQR)). Secondary outcomes included length of stay and opioid-related side effects.ResultsOf 1846 patients identified, 242 were matched and analyzed. Total 24-hour opioid consumption was significantly lower in the erector spinae plane block group (30 mg (0, 144); without-blocks: 45 mg (0, 225); p=0.03). There were no significant differences in pain scores in the postanesthesia care unit (with blocks: 4 (0, 9); without blocks: 4 (0,8); p=0.984) or on the nursing floor (with blocks: 4 (0,8); without blocks: 4 (0,8); p=0.134). Total length of stay was 5 hours shorter in the block group (76 hours (21, 411); without blocks: 81 (25, 268); p=0.001). Fewer patients who received blocks required postoperative antiemetic administration (with blocks: n=77 (64%); without blocks: n=97 (80%); p=0.006).ConclusionsErector spinae plane blocks were associated with clinically irrelevant reductions in 24-hour opioid consumption and no improvement in pain scores after lumbar fusion. The routine use of these blocks in the setting of a comprehensive care pathway for lumbar fusion may not be warranted.
Comparing trauma mortality of injured patients in India and the USA: a risk-adjusted analysis
Authors: Amato Stas , Bonnell Levi , Mohan Monali , Roy Nobhojit , Malhotra Ajai 
Published: November 2021

ObjectivesComparisons of risk-adjusted trauma mortality between high-income countries and low and middle-income countries (LMICs) can be used to identify specific patient populations and injury patterns for targeted interventions. Due to a paucity of granular patient and injury data from LMICs, there is a lack of such comparisons. This study aims to identify independent predictors of trauma mortality and significant differences between India and the USA.MethodsA retrospective cohort study of two trauma databases was conducted. Demographic, injury, physiologic, anatomic and outcome data were analyzed from India’s Towards Improved Trauma Care Outcomes project database and the US National Trauma Data Bank from 2013 to 2015. Multivariate logistic regression analyses were performed to determine significant independent predictors of mortality.Results687 407 adult trauma patients were included (India 11 796; USA 675 611). Patients from India were significantly younger with greater male preponderance, a higher proportion presented with physiologic abnormalities and suffered higher mortality rates (23.2% vs. 2.8%). When controlling for age, sex, physiologic abnormalities, and injury severity, sustaining an injury in India was the strongest predictor of mortality (OR 13.85, 95% CI 13.05 to 14.69). On subgroup analyses, the greatest mortality difference was seen in patients with lower Injury Severity Scores.ConclusionAfter adjusting for demographic, physiologic abnormalities, and injury severity, trauma-related mortality was found to be significantly higher in India. When compared with trauma patients in the USA, the odds of mortality are most notably different among patients with lower Injury Severity Scores. While troubling, this suggests that relatively simple, low-cost interventions focused on standard timely trauma care, early imaging, and protocolized treatment pathways could result in substantial improvements for injury mortality in India, and potentially other LMICs.Level of evidenceLevel 3, retrospective cohort study.
Is the whole greater than the sum of its parts? The implementation and outcomes of a whole blood program in Ecuador
Authors: Himmler Amber , Galarza Armijos Monica Eulalia , Naranjo Jeovanni Reinoso , Patiño Sandra Gioconda Peña , Sarmiento Altamirano Doris , Lazo Nube Flores , Pino Andrade Raul , Aguilar Hernán Sacoto , Fernández de Córdova Lenin , Augurto Cecibel Cevallos , Raykar Nakul , Puyana Juan Carlos , Salamea Juan Carlos 
Published: November 2021

BackgroundHemorrhagic shock is a major cause of mortality in low-income and middle-income countries (LMICs). Many institutions in LMICs lack the resources to adequately prescribe balanced resuscitation. This study aims to describe the implementation of a whole blood (WB) program in Latin America and to discuss the outcomes of the patients who received WB.MethodsWe conducted a retrospective review of patients resuscitated with WB from 2013 to 2019. Five units of O+ WB were made available on a consistent basis for patients presenting in hemorrhagic shock. Variables collected included gender, age, service treating the patient, units of WB administered, units of components administered, admission vital signs, admission hemoglobin, shock index, Revised Trauma Score in trauma patients, intraoperative crystalloid (lactated Ringer’s or normal saline) and colloid (5% human albumin) administration, symptoms of transfusion reaction, length of stay, and in-hospital mortality.ResultsThe sample includes a total of 101 patients, 57 of which were trauma and acute care surgery patients and 44 of which were obstetrics and gynecology patients. No patients developed symptoms consistent with a transfusion reaction. The average shock index was 1.16 (±0.55). On average, patients received 1.66 (±0.80) units of WB. Overall mortality was 13.86% (14 of 101) in the first 24 hours and 5.94% (6 of 101) after 24 hours.DiscussionImplementing a WB protocol is achievable in LMICs. WB allows for more efficient delivery of hemostatic resuscitation and is ideal for resource-restrained settings. To our knowledge, this is the first description of a WB program implemented in a civilian hospital in Latin America.Level of evidenceLevel IV.
Evaluating the effects of fibrolytic enzymes on rumen fermentation, omasal nutrient flow, and production performance in dairy cows during early lactation
Authors: Refat Basim , Christensen David A. , Ismael Aya , Feng Xin , Rodríguez-Espinosa María E. , Guevara-Oquendo Victor H. , Yang Jenchieh , AlZahal Ousama , Yu Peiqiang 
Published: November 2021

This study was performed to evaluate the effects of pre-treating a barley-silage-based diet with an exogenous fibrolytic enzyme derived from Trichoderma reesei (FETR, a mixture of xylanase and cellulase) on lactation performance, omasal nutrient flow and digestibility, rumen fermentation characteristics, and rumen pH profile in Holstein dairy cows during early lactation. The dairy trial was conducted using nine Holstein dairy cows (averaging 46 ± 24 days in milk and 697 ± 69 kg body weight, six cows were fitted with a rumen cannula, and three were non-cannulated). Two groups of cows were randomly assigned to each of the dietary treatments in a crossover design: control (without FETR supplementation) and supplemented [with 0.75 mL of FETR·kg−1 dry matter (DM) of the diet based on our previous study]. The application of FETR tended to decrease the DM intake compared with control. There were no effects of FETR (P > 0. 10) on omasal nutrient flow and digestibility, rumen fermentation characteristics, and rumen pH profile. In conclusion, this study lacks evidence that the fibrolytic enzyme (at a level of 0.75 mL of FETR·kg−1 DM) can affect nutrient digestibility, ruminal fermentation, and the performance of early-lactation cows. Further study with larger animal trials are needed.
Microstructure evolution, thermal conductivity and mechanical properties of hot-rolling Al–Si–Fe–Mg alloy under different reductions
Authors: Guo Yu , Wang Ye , Jiang Bo , Chen Hongtao , Xu Hongyu , Hu Maoliang , Ji Zesheng 
Published: November 2021

To further improve the properties of the Al–11.5Si–0.4Fe–0.35Mg, the effects of different reductions of hot-rolling (HR) Al–Si–Fe–Mg alloy on microstructure, thermal conductivity (TC), and mechanical properties were investigated in this paper. The results show that the eutectic silicon phases are broken and moved during the HR process. The average size of eutectic silicon phase decreases. Meanwhile, the aspect ratio of eutectic silicon phase closer to 1 and the distribution of that are more uniform with the increase of HR reduction. In addition, the ternary Al–Fe–Si phases are also broken after HR. It indicates that the action of shear force induced by the HR process is beneficial to promote refinement and spheroidization of the eutectic silicon phase, hence further improves the properties of the alloy. Apparently, the fine and dispersed distribution of spherical silicon particles can minimize the splitting of the [Formula: see text]-Al matrix, decrease the scattering effect on free electrons, and increase the number of free-electron transport channel. Therefore, the overall performance of HR Al–Si–Fe–Mg alloy with a reduction of 71.25% is the best with the TC of 170.24 W/m[Formula: see text]K, the tensile strength of 241.98 MPa and elongation of 8.73%, respectively.
Digital Image Evolution of Artwork Without Human Evaluation Using the Example of the Evolving Mona Lisa Problem
Authors: Garbaruk Julia , Logofatu Doina , Badica Costin , Leon Florin 
Published: November 2021

Whether for optimizing the speed of microprocessors or for sequence analysis in molecular biology — evolutionary algorithms are used in astoundingly many fields. Also, the art was influenced by evolutionary algorithms — with principles of natural evolution works of art that can be created or imitated, whereby initially generated art is put through an iterated process of selection and modification. This paper covers an application in which given images are emulated evolutionary using a finite number of semi-transparent overlapping polygons, which also became known under the name “Evolution of Mona Lisa”. In this context, different approaches to solve the problem are tested and presented here. In particular, we want to investigate whether Hill Climbing Algorithm in combination with Delaunay Triangulation and Canny Edge Detector that extracts the initial population directly from the original image performs better than the conventional Hill Climbing and Genetic Algorithm, where the initial population is generated randomly.
APOBEC Mutagenesis Inhibits Breast Cancer Growth through Induction of T cell–Mediated Antitumor Immune Responses
Authors: DiMarco Ashley V. , Qin Xiaodi , McKinney Brock J. , Garcia Nina Marie G. , Van Alsten Sarah C. , Mendes Elizabeth A. , Force Jeremy , Hanks Brent A. , Troester Melissa A. , Owzar Kouros , Xie Jichun , Alvarez James V. 
Published: November 2021

Abstract

The APOBEC family of cytidine deaminases is one of the most common endogenous sources of mutations in human cancer. Genomic studies of tumors have found that APOBEC mutational signatures are enriched in the HER2 subtype of breast cancer and are associated with immunotherapy response in diverse cancer types. However, the direct consequences of APOBEC mutagenesis on the tumor immune microenvironment have not been thoroughly investigated. To address this, we developed syngeneic murine mammary tumor models with inducible expression of APOBEC3B. We found that APOBEC activity induced antitumor adaptive immune responses and CD4+ T cell–mediated, antigen-specific tumor growth inhibition. Although polyclonal APOBEC tumors had a moderate growth defect, clonal APOBEC tumors were almost completely rejected, suggesting that APOBEC-mediated genetic heterogeneity limits antitumor adaptive immune responses. Consistent with the observed immune infiltration in APOBEC tumors, APOBEC activity sensitized HER2-driven breast tumors to anti–CTLA-4 checkpoint inhibition and led to a complete response to combination anti–CTLA-4 and anti-HER2 therapy. In human breast cancers, the relationship between APOBEC mutagenesis and immunogenicity varied by breast cancer subtype and the frequency of subclonal mutations. This work provides a mechanistic basis for the sensitivity of APOBEC tumors to checkpoint inhibitors and suggests a rationale for using APOBEC mutational signatures and clonality as biomarkers predicting immunotherapy response in HER2-positive (HER2+) breast cancers.