bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult diet in England: Where is more support needed to achieve dietary recommendations?
Authors: Smith Dianna M. , Vogel Christina , Campbell Monique , Alwan Nisreen , Moon Graham 
Published: June 2021

BackgroundSmall-area estimation models are regularly commissioned by public health bodies to identify areas of greater inequality and target areas for intervention in a range of behaviours and outcomes. Such local modelling has not been completed for diet consumption in England despite diet being an important predictor of health status. The study sets out whether aspects of adult diet can be modelled from previously collected data to define and evaluate area-level interventions to address obesity and ill-health.MethodsAdults aged 16 years and over living in England. Consumption of fruit, vegetables, and sugar-sweetened beverages (SSB) are modelled using small-area estimation methods in English neighbourhoods (Middle Super Output Areas [MSOA]) to identify areas where reported portions are significantly different from recommended levels of consumption. The selected aspects of diet are modelled from respondents in the National Diet and Nutrition Survey using pooled data from 2008–2016.ResultsEstimates indicate that the average prevalence of adults consuming less than one portion of fruit, vegetables or 100% juice each day by MSOA is 6.9% (range of 4.3 to 14.7%, SE 0.06) and the average prevalence of drinking more than 330ml/day of SSB is 11.5% (range of 5.7 to 30.5%, SE 0.03). Credible intervals around the estimates are wider for SSB consumption. The results identify areas including regions in London, urban areas in the North of England and the South coast which may be prioritised for targeted interventions to support reduced consumption of SSB and/or an increase in portions of fruit and vegetables.ConclusionThese estimates provide valuable information at a finer spatial scale than is presently feasible, allowing for within-country and locality prioritisation of resources to improve diet. Local, targeted interventions to improve fruit and vegetable consumption such as subsidies or voucher schemes should be considered where consumption of these foods is predicted to be low.
Is the open access citation advantage real? A systematic review of the citation of open access and subscription-based articles
Authors: Langham-Putrow Allison , Bakker Caitlin , Riegelman Amy 
Published: June 2021

Aims
Over the last two decades, the existence of an open access citation advantage (OACA)—increased citation of articles made available open access (OA)—has been the topic of much discussion. While there has been substantial research to address this question, findings have been contradictory and inconclusive. We conducted a systematic review to compare studies of citations to OA and non-OA articles.

Methods
A systematic search of 17 databases attempted to capture all relevant studies authored since 2001. The protocol was registered in Open Science Framework. We included studies with a direct comparison between OA and non-OA items and reported article-level citation as an outcome. Both randomized and non-randomized studies were included. No limitations were placed on study design, language, or publication type.

Results
A total of 5,744 items were retrieved. Ultimately, 134 items were identified for inclusion. 64 studies (47.8%) confirmed the existence of OACA, while 37 (27.6%) found that it did not exist, 32 (23.9%) found OACA only in subsets of their sample, and 1 study (0.8%) was inconclusive. Studies with a focus on multiple disciplines were significantly positively associated with finding that OACA exists in subsets, and are less associated with finding that OACA did not exist. In the critical appraisal of the included studies, 3 were found to have an overall low risk of bias. Of these, one found that an OACA existed, one found that it did not, and one found that an OACA occurred in subsets.

Conclusions
As seen through the large number of studies identified for this review, OACA is a topic of continuing interest. Quality and heterogeneity of the component studies pose challenges for generalization. The results suggest the need for reporting guidelines for bibliometrics studies.
Diagnostic accuracy of Mycobacterium tuberculosis cell-free DNA for tuberculosis: A systematic review and meta-analysis
Authors: Yu Guocan , Shen Yanqin , Ye Bo , Shi Yan 
Published: June 2021

Background
Diagnosis of tuberculosis (TB) is still difficult. The purpose of our study was to evaluate the diagnostic accuracy of Mycobacterium tuberculosis cell-free DNA (cfDNA) for diagnosing of TB.

Methods
We searched relevant databases for studies that used cfDNA to diagnose TB. We evaluated the accuracy of cfDNA compared with the composite reference standard (CRS) and culture. True positive, false positive, false negative, and true negative values for cfDNA were obtained first, then the estimated pooled sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), diagnostic odds ratio (DOR), and the area under the summary receiver operating characteristic (SROC) curve (AUC) of cfDNA for diagnosing TB were calculated with 95% confidence intervals (CIs). Heterogeneity was determined using the I2 statistic. When the heterogeneity was obvious, the source of heterogeneity was further discussed.

Results
We included 14 independent studies comparing cfDNA with the CRS, and 4 studies compared with culture. The pooled sensitivity, specificity, PPV, NPV, DOR, and AUC of the SROC were 68%, 98%,99%, 62%, 83, and 0.97 as compared with the CRS, respectively. The pooled sensitivity, specificity, PPV, NPV, DOR, and AUC of the SROC were 48%, 91%, 92%, 60%, 5, and 0.88 as compared with culture, respectively. The heterogeneity between studies was significant.

Conclusions
The accuracy of cfDNA testing for TB diagnosis was good compared with CRS and culture. cfDNA can be used for rapid early diagnosis of TB.
Resistance mechanisms and fitness of pyraclostrobin-resistant isolates of Lasiodiplodia theobromae from mango orchards
Authors: He Rui , Yang Ye , Hu Zhizhong , Xue Ru , Hu Yajuan 
Published: June 2021

Background
Stem-end rot, caused by Lasiodiplodia theobromae (Pat.) Griffon & Maubl is a serious postharvest disease in mango. In China, a high prevalence of the QoI fungicides resistance has been reported in the last decade. The study aimed to discuss factors determining rapid development of pyraclostrobin-resistance and its resistance mechanisms.

Methods
To determine the resistance stability and fitness of pyraclostrobin resistance in L. theobromae, three phenotypes of pyraclostrobin resistance were compared and analyzed for the EC50 values, mycelial growth, virulence and temperature sensitivity and osmotic stress sensitivity. The relative conductivity and enzyme activities of different phenotypes were compared under fungicide stress to explore possible biochemical mechanisms of pyraclostrobin resistance in L. theobromae. The Cytb gene sequences of different phenotypes were analysed.

Results
All isolates retained their original resistance phenotypes during the 10 subcultures on a fungicide-free PDA, factor of sensitivity change (FSC) was approximately equal to 1. The resistance-pyraclostrobin of the field isolates should be relatively stable. Two pyraclostrobin-resistant phenotypes shared similar mycelial growth, virulence and temperature sensitivity with pyraclostrobin-sensitive phenotype. After treated by pyraclostrobin, the relative conductivity of the sensitive phenotype was significantly increased. The time of Pyr-R and Pyr-HR reached the most conductivity was about 8–10 times than that of Pyr-S, the time for the maximum value appearance showed significant differences between sensitive and resistant phenotypes. The activities of Glutathione S-transferase (GST), catalase (CAT) and peroxidase (POD) of Pyr-HR were 1.78, 5.45 and 1.65 times respectively, significantly higher than that of Pyr-S after treated by 200 mg/l pyraclostrobin.

Conclusion
The results showed that the pyraclostrobin-resistant phenotypes displayed high fitness and high-risk. The nucleotide sequences were identical among all pyraclostrobin-resistant and -sensitive isolates. The pyraclostrobin resistance was not attributable to Cytb gene alterations, there may be some of other resistance mechanisms. Differential response of enzyme activity and cell membrane permeability were observed in resistant- and sensitive-isolates suggesting a mechanism of metabolic resistance.
Fibrosis-4 Index vs Nonalcoholic Fatty Liver Disease Fibrosis Score in Identifying Advanced Fibrosis in Subjects With Nonalcoholic Fatty Liver Disease: A Meta-Analysis
Authors: Castellana Marco , Donghia Rossella , Guerra Vito , Procino Filippo , Castellana Fabio , Zupo Roberta , Lampignano Luisa , Sardone Rodolfo , De Pergola Giovanni , Romanelli Francesco , Trimboli Pierpaolo , Giannelli Gianluigi 
Published: June 2021

INTRODUCTION:
In subjects with nonalcoholic fatty liver disease (NAFLD), advanced fibrosis (AF) carries the highest risk of adverse liver-related events. To reduce the number of unnecessary biopsies, several noninvasive tools (NITs) for the risk stratification of fibrosis have been developed. We conducted this meta-analysis to assess the performance of the fibrosis-4 index (FIB-4) and NAFLD fibrosis scores (NFS), the 2 most common NITs, for the appropriate selection of subjects with AF for biopsy.

METHODS:
Four databases were searched until December 2020 (CRD42021224766). Original articles reporting data on the performance of FIB-4 and NFS, interpreted according to standard cutoffs in subjects with biopsy-proven NAFLD, were included. Separate data extractions were performed according to the lower cutoff, the higher cutoff, and the dual threshold approach. The numbers of subjects classified as true-negative, true-positive, false-negative, and false-positive were extracted. Summary operating points were estimated using a random-effects model.

RESULTS:
Eighteen studies evaluating 12,604 subjects were included. Participants were adult outpatients with biopsy-proven NAFLD or nonalcoholic steatohepatitis. Overall, a weak-to-moderate performance was found for both scores. The head-to-head comparison showed FIB-4 to be associated with a higher performance in ruling in and NFS in ruling out AF in the single threshold approach, whereas, with the dual threshold approach, a lower prevalence of indeterminate findings was found for FIB-4.

DISCUSSION:
This meta-analysis suggested that currently available NITs have a limited performance in identifying AF among subjects with NAFLD. Further studies are needed to optimize existing thresholds or develop new NITs.
The importance of ISO management system standards in a scenario of profound changes caused by the Covid-19 pandemic to Brazilian companies
Authors: Anholon Rosley , Pavan Serafim Milena , Dibbern Thais , Leal Filho Walter 
Published: June 2021

Goal: The aim of this viewpoint is characterized by emphasizing the importance of the management standards of the International Organization for Standardization as an information base for improvements to Brazilian managers in a scenario of profound changes caused by the Covid-19 pandemic.
Design / Methodology / Approach: Initially, a brief bibliographic research was carried out to base some information presented in the text. Later, the authors of this viewpoint discussed their ideas and established the reflections presented here, many of them based on their experiences and the Brazilian context. Finally, the final considerations were established.
Results: The main reflections are directed in the sense that most Brazilian companies have felt harshly the consequences of the economic crisis resulting from the pandemic of Covid-19 and, in some way, they need to rethink some of their administrative practices. In this scenario of profound organizational changes, we believe that the management standards of the International Organization for Standardization can be characterized as an important knowledge base, since they present information of high credibility, widely debated by experts and that are easily accessible to Brazilian managers in different themes.
Limitations of the investigation: Since it is a viewpoint, part of the information presented here are the perceptions and considerations of the authors.
Practical implications: This viewpoint shows that the standards of the International Organization for Standardization can be used as an important tool for management systems focused on innovation and employee skills management.
Originality / Value: We hope with this viewpoint to advocate for ISO management standards as important instruments of continuous improvement in a scenario of many organizational changes for Brazilian companies.
Experimental study on the dissolution of supercritical CO2 in PS under different agitators
Authors: Wang Long , Huang Xingyuan , Liang Haifeng 
Published: June 2021

Abstract
In the continuous molding of microporous plastics, the polymer/CO2 homogeneous body needs to be formed in a very short time, which affects the subsequent bubble nucleation, bubble pore distribution, and growth, and is the key to the molding. It is known that the formation time of homogeneous body is shortened during the continuous molding of microporous plastics because of the agitator’s effect. However, different agitators have different effects on the dissolution rate. So, it is necessary to study not only the dissolution of gas in polymer melt under static condition but also the dissolution under the action of the agitator. In this article, the solubility and dissolution rate of supercritical CO2 in polymer melt PS at different temperatures and pressures were experimentally investigated under conical and screw agitators, and the numerical solution was also carried out.
The Rule of Law and Its Social Reception as Determinants of Economic Development: A Comparative Analysis of Germany and Poland
Authors: Głowacki Krzysztof , Hartwell Christopher Andrew , Karunska Kateryna , Kurczewski Jacek , Botsch Elisabeth , Göhring Tom , Priesmeyer-Tkocz Weronika 
Published: June 2021

Abstract
The rule of law is not just a necessary condition for a modern liberal society but also an important prerequisite for a stable, effective and sustainable market economy. However, relevant legal norms may be more or less successful depending on their social reception within a particular country. This study explores the connection between the rule of law, especially in terms of how it is viewed socially, and the functioning of market economy in the examples of two geographically contiguous yet often-diverging countries, namely Germany and Poland. We utilise two approaches to examine this issue, first studying societal perceptions of the various dimensions of the rule of law by way of standardized surveys and in-depth interviews conducted in both countries to determine the de facto state of the rule of law in the economic context. Secondly, we measure the effect of the de jure and de facto rule of law on economic outcomes using a multivariate panel analysis. Combining new institutional economics and sociology of law, our analysis finds that Polish firms perceive the rule of law and its execution by the state in a restrictive perspective, contributing to insecurity. German interviewees, however, showcase the supportive and transaction cost-reducing properties of the rule of law, displaying higher trust in the state. These findings are supported by an econometric analysis of the drivers of rule of law in both Poland and Germany, which shows the importance of rule of law in terms of a level playing field contributing to higher levels of investment.
Can a Complicated “Consensus” Survive a Dose of Populist Poison? Exploring the Potential Impact of Brexit and Trumpism on the Developed Country Approach to Trade Law and Policy
Authors: Stacy Sean 
Published: June 2021

Abstract
Among wealthier, so-called “developed” nations, a consistent and shared policy orientation on trade has generally prevailed over the last three quarters of a century. This consensus has been hallmarked by the promotion of freer trade facilitated by a state-centric, rules-based legal system. While most wealthy countries appear to desire a continued fidelity to that policy orthodoxy, the United Kingdom’s (UK’s) ‘Brexit’ decision and the United States’ (US’) increasingly antagonistic stance toward World Trade Organization (WTO) dispute settlement beg the question as to whether fissures in the consensus are forming. This paper examines the depth of the perceived consensus and the degree to which US and UK actions signify a turning point. As part of this examination, populism’s role in promoting change in the US, UK and beyond, is explored.
Ovarian female adnexal tumor of probable Wolffian origin – Case report
Authors: Vučković Ljiljana , Klisic Aleksandra , Miladinović Mirjana 
Published: June 2021

Abstract

Background
During embryonic development in women, a regression of temporary embryonic structures – mesonephric (Wolffian) ducts occurs. Adnexal tumors of Wolffian duct origin (FATWO) are rare.

Case report
We presented the case of a 64-year-old female patient who was diagnosed with FATWO. After the surgical treatment, the uterus with bilateral adnexal structures was submitted for histopathological analysis. The left ovary was occupied by a tumor measuring 80 × 60 × 50 mm, with smooth, shiny, whitish surface. Tumor cells were medium-sized, relatively uniform, round, and polygonal, with eosinophilic cytoplasm and centrally laid nucleus with fine chromatin, organized into solid, trabecular, and tubular formations. Tumor cells were positive for pancytokeratin (CK), CK7, CD10, neuron-specific enolase (NSE), synaptophysin, calretinin, progesterone, estrogen, and epithelial membrane antigen (EMA).

Conclusion
This case adds a report of a rare tumor to the literature. We must think of it in the differential diagnostic algorithm to make an accurate diagnosis for selecting the best treatment modality.
Konzeption und Gestaltung von Learningstreams
Authors: Link Maike , Schmidhäuser Paul , Fehrle Anna 
Published: June 2021

Abstract
Der Wandel der Arbeitswelt erfordert angepasste Qualifikations- und Kompetenzprofile. Um den Anforderungen nach lebenslangem und praxisrelevantem Lernen nachzukommen, gilt es die Lernorganisation neu zu denken. Ein relevantes Lernkonzept in diesem Zusammenhang ist das „Blended Learning“. Im vorliegenden Beitrag wird aufgezeigt, wie Lernprozesse („Learningstreams“) entlang dieses Konzepts sowohl methodisch als auch didaktisch konzipiert und anhand der Verknüpfung verschiedener Methoden und Trainingsformate gestaltet werden können.
Das TMKB-Modell
Authors: Maier Markus , Fischer Tobias 
Published: June 2021

Abstract
Das TMKB-Modell beschreibt einen Weg, den persönlichen und unternehmerischen Erfolg im beruflichen Alltag effizient und nachhaltig zu erreichen. Hierbei steht TMKB für den Transfer von Methoden und Kompetenzen in den Beruf. Dieses Modell beachtet die Theorien der Kompetenzentwicklung im Kontext realer Problemstellungen in Unternehmen. Beispielhaft wird das TMKB-Modell in der ersten Stufe mit dem Schwerpunkt Lean- und Projektmanagement erläutert. Die Zielgruppe dieses Ansatzes lässt sich über die der Auszubildenden bis hin zu Studierenden und Berufserfahrenen erweitern.
Neue Planungsmethodik für Anlagen mit Mensch-Roboter-Kollaboration
Authors: Kurth Johannes , Wagner Marcel 
Published: June 2021

Abstract
Die Mensch-Roboter-Kollaboration (MRK) ist weiterhin in aller Munde. Es gibt erfolgreiche Anwendungen. Der große Durchbruch hat jedoch noch nicht stattgefunden. Ein wesentlicher Grund liegt darin, dass MRK in der Einführungsphase nur in bestehende Anlagen integriert wurde, die aber nicht für MRK vorbereitet oder geeignet sind [1]. Die ganzen Vorteile von MRK werden erst bei Neuanlagen nutzbar, aber auch nur dann, wenn neue Methoden zur Planung der Anlage genutzt werden. Dieser Beitrag zeigt auf, welche Änderungen notwendig sind, und stellt eine erweiterte Planungsmethodik sowie Planungsprinzipien für MRK vor.
Demontageeffektor für Schraubverbindungen mit ungewissem Zustand
Authors: Rieß Simon , Laub Jannis , Coutandin Sven , Fleischer Jürgen 
Published: June 2021

Abstract
In diesem Beitrag wird die systematische Entwicklung einer Schraubeinheit für Industrieroboter vorgestellt, mit derer Hilfe ein Roboter die Demontage von Elektromotoren vornehmen kann. Aufgrund der Anwendung im Remanufacturing, haben die Elektromotoren bereits einen Lebenszyklus durchlaufen und zeichnen sich durch ungewisse Produktzustände aus. Der Schraubeffektor ist unabhängig davon im Stande, verschiedene Schrauben zu lösen und dabei Messwerte aufzunehmen.
Künstliche Intelligenz in optischen Mess- und Prüfsystemen
Authors: Marquardt Erik 
Published: June 2021

Abstract
Bildverarbeitungssysteme sind in Geräten und Anlagen der Mess- und Automatisierungstechnik weit verbreitet. Nun werden immer mehr Bildverarbeitungssysteme mit KI, konkret mit künstlichen neuronalen Netzen, ausgestattet. Werden diese Systeme die Bildverarbeitungswelt auf den Kopf stellen? Oder ist KI in optischen Mess- und Prüfsystemen ein Hype-Thema, das bald wieder vergessen ist? In diesem Beitrag stellen wir die Konzepte der klassischen Bildverarbeitung und der KI-basierten Systeme gegenüber, diskutieren die jeweiligen Stärken und Schwächen und arbeiten die Chancen heraus, die sich dadurch ergeben.
ORAI3 contributes to hypoxia-inducible factor 1/2α-sensitive colon cell migration
Authors: Zhu D. , He R. , Yu W. , Li C. , Cheng H. , Zhu B. , Yan J. 
Published: June 2021

AbstractBackgroundHypoxia is a pivotal initiator of tumor angiogenesis and growth through the stabilization of hypoxia-inducible factors (HIFs). This study set out to examine the involvement of HIF-1α and HIF-2α in colon cancer and ascertained whether ORAI3 was involved in the pathway.Materials and methodsPatients and murine models as well as human colorectal adenocarcinoma tumor (CW2) cells were included to examine the levels of ORAI1/3 and HIF-1/2α levels. Calcium imaging was utilized to ascertain the activity of calcium channel. Scratch assay was used to assess the migration capacity of the cells.ResultsTumors from murine colon cancer xenograft models and patients with colon cancer displayed high ORAI1/3 and HIF-1/2α levels. Hypoxia treatment, mimicking the tumor microenvironment in vitro, increased ORAI1/3 and HIF-1/2α expression as well as store-operated Ca2+ entry (SOCE). Of note is that HIF-1/2α silencing decreased SOCE, and HIF-1/2α overexpression facilitated SOCE. Furthermore, ORAI3 rather than ORAI1 expression was inhibited by HIF-1/2α silencing while increased by ML228. Luciferase assay also confirmed that ORAI3 was elevated in the presence of ML228, indicating the linkage between HIF-1/2α and ORAI3. Additionally, colony-forming potential and cell migration capacity were decreased in siHIF-1α and siHIF-2α as well as siORAI3 cells, and the facilitating effect of ML228 on cell migration and colony-forming potential was also decreased in siORAI3 CW-2 cells, which points out the importance of ORAI3 in HIF1/2α pathway.ConclusionOur findings allow to conclude that both HIF-1α and HIF-2α facilitate ORAI3 expression, hence enhancing colon cancer progression.