bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precise and Convergence Pattern Was Obtained in the Detection of Mammary Gland Carcinoma Using Molybdenum Enhanced Poly Taurine Nano-biofilms Compared to Pathological Examination
Authors: Nasrollahpour Hassan , Khalilzadeh Balal , Rahbarghazi Reza , Erk Nevin , Rashidi Mohammad-Reza , Naseri Abdolhossein 
Published: September 2021

Abstract
The development of high-performance sensing frameworks for the diagnosis of anaplastic changes is the subject of debate. The lack of on-time diagnosis in patients with suspicious cancers can affect the prognosis and survival rate. As a correlate, the emergence of de novo strategies for the development of transducing frameworks has an inevitable role in advanced biosensing. The combination of green chemistry procedures with eco-friendly and biocompatible materials is of high desirability in this context. The synthesis of new biocompatible and cost-effective nanomaterials to meet the emerging needs of rising demands appeals to new synthetic methodologies. Here, we applied the electrochemical synthesis method to the fabrication of biocompatible and subtly governed Molybdenum trioxide/poly taurine nano-bio films for the monitoring of human epidermal growth factor receptor-2 (HER-2) in sera from breast cancer patients. Morphological and elemental assessments were performed using scanning electron microscope, energy dispersive X-Ray spectroscopy, and dot mapping analyses. In addition, HER-2 immunohistochemistry (IHC) staining was performed on tissue samples and data compared to the values obtained by Molybdenum trioxide/poly taurine nano-bio films. We also noted our platform is eligible for feasible, rapid, and specific determination of HER-2 factor in human samples. The method had a lower limit of quantification of 0.000001 ng mL-1 and a linear dynamic range between 0.1 ng mL-1 and 0.000001 ng mL-1. IHC imaging showed that the degree of anaplastic changes in breast samples (intensity of HER-2 factor) was closely associated with the intensity of signals obtained by our developed immunosensor.
Maintenance Accessibility Evaluation Method based on D-H Model and Comfort in a Virtual Maintenance Environment
Authors: Zhou Dong , Wu Hongduo , Guo Ziyue , Zhou Qidi , Liang Yuning 
Published: September 2021

Abstract
In virtual maintenance, the most widely used accessibility evaluation method is to use virtual human reach envelope surface to judge and evaluate accessibility. However, this method can only give two kinds of evaluation results: reachable and unreachable. There is not enough data and theoretical support for the construction of envelope surface, and the precision and accuracy of evaluation need to be improved. In this paper, a parameterized accessibility evaluation method and a method of accessibility envelope surface construction are proposed. Firstly, to objectively describe the movement of human body, a 6-joint and 5-link D-H (Denavit-Hartenberg) link model is established from the waist to the fingertip of the human body, and the ranges of 10 degrees of freedom and angles related to accessibility are determined according to ergonomics. Then, comfort is introduced to refine the accessibility evaluation, and a multi-level accessibility evaluation system based on comfort is constructed according to RULA (the rapid upper limb assessment). In order to facilitate the application of this method in virtual environment, a method of accessibility envelope surface construction is proposed. Firstly, the reachable points are generated by Monte Carlo simulation based on the D-H model. Secondly, the accessibility envelope surface is composed of the outermost random reachable points. Finally, the comparison experiment with the reachable envelope provided by DELMIA in virtual environment shows that the proposed method is more accurate, meticulous and objective. Based on this method, an accessibility evaluation tool has been developed in CATIA and has been applied in some scientific research institutes.
Predicting traffic flow during peak commuting hours
Authors: Shen Z. 
Published: September 2021

Abstract
Traffic congestion during the peak commuting period is becoming more and more serious in many cities in China. Accurate prediction of traffic flow on urban roads during the peak commuting period is one of the key fundamental problems to reduce traffic congestion and build intelligent transportation. This paper proposes a low-cost and high-efficiency method to address the challenges of the existing ORIGIN-DESTINATION survey method, which is costly, inefficient and has limited accuracy of results. By using the city-wide traffic, social security, insurance, population and other digital city data, we group the residents' travel modes into four types: walking, public transportation, rail transit and self-driving based on the service radius and travel distance of transportation, and analyze and count the number of private car trips and rail transit passenger flow by using the rail transit priority principle and the shortest path algorithm, and predict the commuting peak period based on this method. The road traffic flow during the peak commuting period is also predicted. The validity and reliability of the method are demonstrated by using typical data of Wuhan city as an example.
Spatial Scale Patterns of Genetic Diversity and Gene Flow in Populations of Sweet Detar (Detarium microcarpum Guill. &amp; Perr.; Fabaceae)
Authors: AGBO Relique Ignace , Missihoun Antoine , Montcho David , Dagba Rollande , Sédah Paulin , Agbangla Clément 
Published: September 2021

Abstract
The main objective of this study is to investigate the patterns of genetic diversity and phylogenetic relationships within populations of Detarium microcarpum (Fabaceae) relative to different spatial conditions. Seventy-eight (78) accessions of D. microcarpum belonging to six populations (Phytogeographic districts) were sampled. In order to have very good quality DNA for molecular analysis, an optimization of the DNA isolation protocol was made. The molecular analysis of the accessions was carried out using 7 chloroplast microsatellite markers. The polymorphism rate (P) is 85.71% and the Polymorphism Information Content (PIC) was in the range of 0.43 (Ntcp_9) to 0.73 (Ccmp_2) with an average of 0.59. Allelic richness (A) ranged from 1.41 to 2.85 with an average of 2.04. The observed heterozygosity (Ho) ranged from 0.23 to 0.60 with an average of 0.39. The expected heterozygosity (He) ranged from 0.43 to 0.60 with a mean of 0.50. Wright's fixation index (FIS) ranged from − 0.17 to 0.47. The effective allele (Ae) is between 1.77 and 2.53 with an average of 2.02. Wright differentiation index (FST) was 0.024. Phylogenetic analysis revealed that the NST value was significantly higher than the GST value (NST = 0.452; GST = 0.190; P < 0.05). A relatively low hd haplotype diversity is obtained (Hd = 0.320). AMOVA analysis showed that 17.35% of the variation existed within populations but 45.80% among populations within the species. Neighbor-Joining phylogenetic tree of D. microcarpum revealed three non-distinct clusters haplotypes showing the existence of gene flow between populations of the species. Our findings of genetic structure and gene flow of D. microcarpum populations based on different spatial conditions is caused by evolutionary forces such as scattering and pollination.
Synergistic Effect of Hypokalemia and Atrial Fibrillation on Prognosis in
Patients with Stroke after Intravenous Thrombolysis
Authors: Wei Li-Min , Ge Wan-Qian , Huang Jia-Sheng , Zhou Cheng-Ye 
Published: September 2021

Background:
The association between atrial fibrillation (AF) and the prognosis of intravenous
thrombolysis (IVT) in patients with Acute Ischemic Stroke (AIS) is debated. Hypokalemia
is highly prevalent in patients with AF. We aimed to investigate the effect of hypokalemia and AF
on the prognosis of AIS patients following IVT.

Method:
AIS patients undergoing IVT were enrolled and divided into four groups: normokalemia
and non-AF, normokalemia and AF, hypokalemia and non-AF, hypokalemia and AF. Logistic regression
was applied to analyze the impact of hypokalemia, AF, and their combination on the prognosis
of patients.

Results:
The analysis included 567 patients, 184 with 3-month poor prognosis (modified Rankin
Scale score of 3-6). Following adjustment of risk factors, hypokalemia and AF increased the risks
for 3-month poor prognosis (adjusted Odds Ratios (aOR) = 4.97; 95% confidence interval (CI),
1.99-12.44, P =.001), early neurological deterioration (END) (aOR=7.98; 95% CI, 3.55-17.95, P
<.001), 1-year poor prognosis (aOR=5.05; 95% CI, 1.99-12.81, P =.001), 1-year all-cause death
(aOR =6.95; 95% CI, 2.35-20.56, P <.001). Patients with normokalemia and AF merely increased
the risk of 1-year all-cause death (aOR=2.69; 95% CI, 1.10-6.61, P=.013). Patients with hypokalemia
and non-AF were not associated with any poor prognosis. There were combined and interactive
effects of hypokalemia with AF on the 3-month poor prognosis (P for interaction =.039)
and END (P for interaction=.005).

Conclusion:
Hypokalemia and AF synergistically increased the risk of near-term poor prognosis,
END, long-term poor prognosis, and all-cause death of AIS patients following IVT.
The Association Between Self-reported Food Addiction Symptoms and
Obesity Among Adults: A Cross-sectional Study
Authors: Alhaj Omar A. , Mahmoud Iman , Sharif Amina , Saif Zahra , Jahrami Haitham , Morris Keith 
Published: September 2021

Background:
The prevalence of overweight and obesity is still on the rise worldwide.
Uncontrolled craving for specific foods has been associated with overweight/ obesity,
categorizing them as possible abuse-related disorders with food addiction (FA) as their possible
main phenotype. The association between FA and the onset of overweight/ obesity is still
controversial, yet scientifically plausible and is the focus of many recent overweight/ obesityrelated
investigations.

Objective:
The current study was the first to examine the association of FA symptoms and obesity
among young Bahraini adults.

Methods:
This study was designed using a cross-sectional research method recruiting a convenience
sample of 654 adults aged 18-35 years. FA prevalence using Yale Food Addiction
Scale (YFAS), sociodemographic, and anthropometric data, were collected using an online
self-declared, semi-structured questionnaire. The descriptive results of the YFAS survey and
the sociodemographic and anthropometric information were reported using descriptive statistics.
Multiple regression test was utilized to analyze the correlations among examined factors.

Results:
A total of 124 (18.96%) participants met the criteria for FA. Responses showed that
females had a slightly higher proportion of FA compared to the male participants. Results also
showed no statistically significant association between various body mass index (BMI) categories
and YFAS. For overweight participants, gender p = 0.018 appeared to be a significant predictor
for BMI; and for obese participants, age p=0.001 and sex p= 0.001 appeared to be significant
predictors of BMI.

Conclusions:
No significant correlation was found between FA and BMI, age, and gender; on
the other hand, age and gender were significant predictors for BMI.
Molecular Mechanisms Responsible for In Vitro Cytotoxic Attributes of Conyza bonariensis Extract against Lymphoblastic Leukaemia Jurkat Cells
Authors: Saleem Mohammad , Schini-Kerth Valerie B. , Hussain Khalid , Khalid Syed H. , Asif Muhammad , Alhosin Mahmoud , Akhtar Muhammad F. , Ahmad Bashir , Raza Atif , Mahrukh  
Published: September 2021

Background:
Conyza bonariensis is known to have anti-cancer properties.

Objective:
The current study investigated the in vitro pro-apoptotic properties of Conyza bonariensis (C. bonariensis)
towards human lymphoblastic leukemia Jurkat cells.

Methods:
Ariel parts of C. bonariensis were macerated in a non-polar (n-Hexane) solvent. MTS cell viability assay
was employed to determine the cytotoxic activity of the extract towards human leukemia Jurket cells and normal Peripheral
Blood Mononuclear Cells (PBMCs). The phytochemical composition of the extract was screened using HPLC
method. Flow cytometric studies (FACS) were conducted to explore the pro-apoptotic potential of the extract. Western
blot studies were employed to identify the molecular targets involved in the induction of apoptosis

Results:
The n-hexane extract showed selective cytotoxic activity towards Jurkat cells. FACS analysis indicated that
the extract induced early and late apoptosis in Jurkat cells. Western blot studies revealed that the extract downregulated
the expression of DNMT1, SIRT1, and UHRF1 with a simultaneous up-regulation of p73 and caspases-3
proteins expression. HPLC characterization of the extract revealed the presence of phenolic compounds.

Conclusion:
Overall, these findings demonstrate that the anti-cancer effects of a Conyza bonariensis extract towards
human lymphoblastic leukemia Jurkat cells are due to the modulation of the activity of multiple oncogenic and tumor
suppressor proteins. Phenolic contents of the extract are proposed to be responsible for these activities.
Persistent Hiccups as an Atypical Initial Presentation of COVID-19: A
Case Report
Authors: Dadras Omid , Asghari Alimohamad , Nosratzahi Atefe 
Published: September 2021

Introduction:
SARS-CoV-2 is a novel coronavirus that causes acute respiratory syndrome
in humans. It is also known as COVID-19 and was first discovered in Wuhan, Hubei Province in China
in December 2019 and soon became a global pandemic. The common symptoms of COVID-19 include
fever, fatigue, and dry cough; however, there are some atypical symptoms that remain either unreported
or underreported.

Case summary:
In this case report, we described a 48-year-old diabetic man who presented with the
chief complaint of persistent hiccups (<48h) to the emergency room with no history of malignancy, GI,
cardiovascular, or neurological diseases. The patient also mentioned intermittent cough and mild dyspnea
initiated the morning of admission day. On physical examination, other than mild tachycardia and
tachypnea, there were no notable findings. Following an abnormal chest X-Ray, a chest CT scan was
carried out, and peripheral ground-glass opacities along with scattered round opacities were identified
in both lungs’ fields. Given the strong suspicion of COVID-19, an RT-PCR test was performed, and
the symptomatic treatment was initiated. The patient was diagnosed with COVID-19 following the
PCR result release. The treatment was initiated per the protocol, and the patient was transferred to the
isolated room and discharged after four days following the relief of the symptoms.

Conclusion:
It is critical for medical practitioners to seriously consider the possibility of COVID-19 in
a patient with similar presentations and isolate the patient at the asymptomatic stages to eliminate the
possibility of virus transmission.
Effect of Red Mud Content on the Physical and Mechanical Properties of the Composites Fabricated using Recycled Pet Resin
Authors: Singh Gurpreet , Kumar Harmesh , Singh Sehijpal 
Published: September 2021

Background:
Red Mud (RM) is a solid waste produced by alumina production in the
Bayer process. At present, it is being stored or dumped on the land or in the oceans. To utilize
RM, extensive work has been done by the researchers to develop various techniques. The production
of PC (Polymer Concrete) is one of the economical and efficient methods to recycle the RM.

Methods:
In this study, the RM has been utilized to fabricate the PC using the recycled PET resin
as the binder with fly ash, silica fume and foundry sand as the fillers. By varying the RM content,
the influence on the workability, shrinkage, ultrasonic velocity, toughness, modulus of elasticity,
mechanical strength, water absorption and acid resistance has been observed.

Results:
For the specimens cured for 56 days, the values of compressive strength, flexural
strength and split tensile strength have been increased by 20.26%, 49.11% and 61.99%, respectively.
The water absorption has been reduced by 23.5%. Also, the loss in compressive strength
under the effect of the 30%HCl has been decreased by 25%.

Conclusion:
The specimens containing 20% of red mud content have shown maximum values.
Fine particles of RM have increased the mortar compactness and produced high-density PC with
reduced density, and the ultrasonic pulse velocity has been reduced due to a decrement in density
and modulus of elasticity values.
Preference of the Waterlily Aphid, Rhopalosiphum nymphaeae (Hemiptera: Aphididae) on Four Hostplants
Authors: Fahmi Ilmam Zul , Putra Nugroho Susetya , Indarti Siwi , Sato Satoru 
Published: September 2021

Waterlily aphid Rhopalosiphum nymphaeae is one of the aphids that have many hosts, including Azolla filiculoides, Limnobium laevigatum, Monochoria vaginalis and Spirodela polyrhiza. The aim of this study was to study the effect of host shift and confirm the results of previous studies on the effect of nitrogen and carbon factors among A. filiculoides, L. laevigatum, M. vaginalis and S. polyrhiza on the level of aphid preference and number of offspring. Analysis of the nitrogen and carbon content of plants was also carried out to confirm the preference and number of offspring produced by aphids. The study began with maintaining aphids on the four tested hosts, up to the 4th generation. Twenty five individuals were randomly selected from each host, then released on the inner wall of the plastic container (14 x 7.5 x 15 cm3) which was filled with four hosts arranged side by side. Observations were made every 24 hours up to 97 hours starting from the first hour after treatment. Observations after 97 hours showed that waterlily aphids imago preferred L. laevigatum the most (49.28%), then on M. vaginalis (20.43%), S. polyrhiza (16.33%), and A. filiculoides (1.75%). Meanwhile, the number of offspring produced by each group of aphids that selected on four hosts were: 46.65 individuals on L. laevigatum, 37.8 individuals on M. vaginalis, 19 individuals on S. polyrhiza, and 0.6 individuals on A. filiculoides. The analysis showed that the highest nitrogen content was found in M. vaginalis (4.16%), followed by S. polyrhiza (3.71%), L. laevigatum (2.33%), and A. filiculoides (2.08%).
Cost–effectiveness of empagliflozin versus weekly semaglutide as add-on therapy for Type 2 diabetes
Authors: Zupa Margaret F , Codario Ronald A , Smith Kenneth J 
Published: September 2021

Aim:
Perform a cost–effectiveness analysis of addition of subcutaneous semaglutide versus empagliflozin to usual treatment for patients with Type 2 diabetes and cardiovascular disease in US setting.
Materials & methods:
A Markov decision model estimated the impact of each strategy using cardiovascular complication rates based on EMPA-REG and SUSTAIN-6 trials. Modeled cohorts were followed for 3 years at 1-month intervals beginning at age 66.
Results:
Compared with empagliflozin, semaglutide resulted in cost of US$19,964 per quality-adjusted life-year gained. In one-way sensitivity analysis, only semaglutide cost >US$36.25/day (base case US$18.04) resulted in empagliflozin being preferred at a willingness-to-pay threshold of US$50,000/quality-adjusted life-year gained.
Conclusion:
For patients with Type 2 diabetes and cardiovascular disease, semaglutide is likely more cost-effective than empagliflozin added to usual treatment.
Pemberdayaan Siswa dan Siswi SMA Plus Muhammadiyah Kota Subulussalam Melalui Program Bimbingan Belajar KPM DRI Selama Pandemi Covid-19
Authors: Cahyadi Cibro Aldi , Januar Eka 
Published: September 2021

One of the problems experienced by some SMA Plus Muhammadiyah students in the city of Subulussalam is a lack of awareness of the potential of each individual, which if they maximize this potential it can be used as additional resources to produce a positive impact on themselves even for the surrounding crowd. One of the programs implemented to increase the potential of SMA Plus Muhammadiyah students is KPM DRI tutoring during the Covid-19 pandemic. This activity was held with the aim of 1) to build students' awareness of the importance of science. 2) to create and realize quality human resources with character, creative and innovative potential. 3) to encourage students to be more enthusiastic about learning and achieving brilliant achievements. The expected result through the KPM DRI tutoring program during the Covid-19 pandemic is an increase in the enthusiasm of students to be more active in exploring their potential. In addition, the KPM DRI tutoring program during the Covid-19 pandemic can also help students who have difficulty doing school assignments given while doing routine learning in class.
Pucuk Bang, A Balinese Musical Composition Komposisi | Pucuk Bang, Sebuah Komposisi Karawitan Bali
Authors: Yunadika Dwiki , I Ketut Muryana  
Published: September 2021

Bunga pucuk bang masih dibutuhkan untuk kepentingan upacara keagamaan. Selama agama Hindu masih tetap tegak di Bali, bunga pucuk bang akan tetap dibutuhkan. Tidak sekedar memenuhi kebutuhan sarana upakara, bunga pucuk bang juga memiliki nilai yang khusus, yang patut kita jaga dan lestarikan keberadaanya. Pucuk bang merupakan judul dari karya tabuh kreasi ini, yang menggunakan media ungkap gamelan gong kebyar. Karya ini terinspirasi darimelihat tanaman bunga pucuk bang yang ada di pekarangan rumah. Dari pemaknaan bunga pucuk bang secara etimologis, terciptalah karya pucuk bang ini. Metode yang digunakan dalam garapan ini ialah metode yang dikemukan oleh Alma M. Hawkins, dalam penciptaan tari yaitu Tahap Penjajagan (eksplorasi), Tahap Percobaan (improvisasi), dan Tahap Pembentukan (forming). Konsep dari garapan ini berpedoman pada konsep Tri Angga (kawitan, pengawak, pengecet) dan masih menggunakan pola-pola tradisi. Pola-pola tradisi tersebut dikembangkan baik dari struktur lagu, teknik permainan/motif permainan dengan penataan unsur-unsur musikal seperti: nada, melodi, ritme, tempo, harmoni dan dinamika. Karya tabuh kreasi yang berjudul pucuk bang ini memiliki durasi 11 menit kurang 12 detik dengan menggunakan 28 pendukung termasuk penata. Karya tabuh kreasi pucuk bang ini disajikan secara konser, yang di rekam di Green Kubu, Br. Sebunibus, Nusa Penida.