bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the change in the biological structure of the tumor in metastatic breast cancer
Authors: Haksoyler Veysel , Koseci Tolga , Cil Timucin , Duman Berna Bozkurt , Olgun Polat , Bayram Ertugrul , Caparlar Mehmet Ali 
Published: March 2021

Objective: When metastasis develops in some breast cancer patients, hormone receptors (HR) and Human Epidermal Growth Factor-2 (Her-2) status can change and the tumor alters its character. We tried to determine the rate of these changes in tumor biology in 110 patients that we followed in our clinic and performed the change of the biopsy from the metastatic site (re-bx). We aimed to determine the biological changes of tumors and, contribute to the literature by examining the relationship of these changes with the adjuvant endocrine treatments (ET) or chemotherapy type (CT).
Material and Methods: We included 110 metastatic breast cancer patients in our study. These patients had previously completed their local treatments followed by CT, and those with positive HR completed ET. After the first metastasis developed in the patients, we performed metastasectomy or biopsy from the metastatic site.
Results: The median ki-67 value was 25% at the time of primary diagnosis and 30% in re-bx. 20.9% of patients estrogen receptor (ER), 31.8% of patients progesterone receptor (PR) and 26.3% of patients Her-2 changed when metastasis developed.
Conclusions: We found that the metastatic tumor has more aggressive properties than the primary tumor. Adjuvant chemotherapy and endocrine treatments or the location of metastasis did not make a significant difference in tumor biology.
MANAJEMEN PROGRAM ADIWIYATA DI SMP NEGERI 1 MENTAYA HILIR SELATAN KABUPATEN KOTAWARINGIN TIMUR
Authors: Riki Muhammad , Sumarnie  
Published: March 2021

Abstrak: Penelitian ini bertujuan untuk mendeskripsikan Manajemen Program Adiwiyata di SMP Negeri 1 Mentaya Hilir Selatan Kabupaten Kotawaringin Timur. Penelitian ini menggunakan pendekatan kualitatif dengan rancangan studi kasus. Sumber data meliputi: kepala sekolah dan guru. Teknik pengumpulan data dilakukan dengan observasi, wawancara, dan dokumentasi. Analisis data dilakukan melalui: reduksi data, penyajian data, dan penarikan kesimpulan. Pengabsahan data menggunakan teknik triangulasi. Hasil penelitian menunjukkan bahwa: (1) Perencanaan program adiwiyata dilakukan dengan membentuk tim adiwiyata sekolah, menerapkan pembelajaran dengan mengintegrasikan PLH, melakukan kegiatan gotong royong dengan melibatkan warga sekolah dan juga masyarakat, tersedianya air bersih, tempat sampah terpisah yang berjenis organik dan non organik; (2) Pelaksanaan secara keseluruhan berjalan dengan baik; (3) Monitoring dan evaluasi dilakukan oleh kepala sekolah selaku penanggung jawab dengan memantau setiap kegiatan yang sedang berjalan agar sesuai dengan rencana, dan (4) Faktor pendukung tersedianya sarana dan prasarana sekolah yang memadai untuk mendukung kegiatan; sedangkan penghambat terkait dengan dana yang belum memadai untuk mendukung variasi kegiatan.
Abstract: This study aims to describe the Adiwiyata Program Management at SMP Negeri 1 Mentaya Hilir Selatan, Kotawaringin Timur Regency. This study used a qualitative approach with case study design. Data sources include: school principals and teachers. The data collection technique was done by observing, interviewing and documenting. Data analysis was carried out through: data reduction, data presentation, and drawing conclusions. The data validation used triangulation technique. The results showed that: (1) Planning the Adiwiyata program was carried out by forming a school adiwiyata team, implementing learning by integrating PLH, carrying out mutual cooperation activities involving school members and the community, providing clean water, separate organic and non-organic types of trash; (2) Overall implementation is going well; (3) Monitoring and evaluation is carried out by the principal as the person in charge by monitoring every ongoing activity so that it is in accordance with the plan, and (4) supporting factors for the availability of adequate school facilities and infrastructure to support activities; while the obstacle relates to insufficient funds to support a variety of activities.
Implicit causality biases and thematic roles in American Sign Language
Authors: Frederiksen Anne Therese , Mayberry Rachel I. 
Published: March 2021

AbstractImplicit causality (IC) biases, the tendency of certain verbs to elicit re-mention of either the first-mentioned noun phrase (NP1) or the second-mentioned noun phrase (NP2) from the previous clause, are important in psycholinguistic research. Understanding IC verbs and the source of their biases in signed as well as spoken languages helps elucidate whether these phenomena are language general or specific to the spoken modality. As the first of its kind, this study investigates IC biases in American Sign Language (ASL) and provides IC bias norms for over 200 verbs, facilitating future psycholinguistic studies of ASL and comparisons of spoken versus signed languages. We investigated whether native ASL signers continued sentences with IC verbs (e.g., ASL equivalents of ‘Lisa annoys Maya because…’) by mentioning NP1 (i.e., Lisa) or NP2 (i.e., Maya). We found a tendency towards more NP2-biased verbs. Previous work has found that a verb’s thematic roles predict bias direction: stimulus-experiencer verbs (e.g., ‘annoy’), where the first argument is the stimulus (causing annoyance) and the second argument is the experiencer (experiencing annoyance), elicit more NP1 continuations. Verbs with experiencer-stimulus thematic roles (e.g., ‘love’) elicit more NP2 continuations. We probed whether the trend towards more NP2-biased verbs was related to an existing claim that stimulus-experiencer verbs do not exist in sign languages. We found that stimulus-experiencer structure, while permitted, is infrequent, impacting the IC bias distribution in ASL. Nevertheless, thematic roles predict IC bias in ASL, suggesting that the thematic role-IC bias relationship is stable across languages as well as modalities.
Pelatihan Pelayanan Terhadap Customer Pada Masa Pandemi
Authors: Liando Sinli Gloria 
Published: March 2021

This research is aimed at the importance of maximum service to customers during this pandemic. In various countries, it is no exception to Jakarta that has already exercised large-scale social restrictions (PSBB). A lot of cafes and restaurants. A keep open only to serve food by the way takeaway or the food purchased should be taken home. Even though slowly "came to life. Business leaders and visitors will also maintain an orderly medical protocol. This guide included specific provisions that were obligatory to obey besides common protocols such as wearing a mask, ensuring the cleanliness of one's hands and checking health conditions. Old story cafe is one of the cafes in the area of a coffee hut that applies health protocols to prevent the risk of transmission of a covid-19 virus. Employee training should still be closed. They the road even in conditions of the corona virus pandemic so that employee work productivity remainsmes done awake, employee training can be done online, both for internal programs companies, as well as external corporate programs, employee training can also be done by companies.
Keywords: Service, Training, Cafe, Visitors and Pandemics.
Optimization of planning radionuclide diagnostic tests in osteoscintigraphy
Authors: Maksimova N. A. , Karpun V. G. , Arzamastseva M. A. , Ilchenko M. G. , Shlyk O. S. 
Published: March 2021

Purpose of the study. Determining maximum possible number of high-quality radionuclide studies by days of the generator operation.Materials and methods. We studied the factors influencing the capacity of radionuclide diagnostic tests in osteoscintigraphy (OSG) by days of service life of a 99mTc generator GT-4K. The OSG capacity, the required resource of 99mTc and its efficiency in OSG were calculated. The optimal days for the generator delivery were determined.The Pirfotech 99mTc radiopharmaceutical (RFP) prepared with the generator was used for OSG.Scanning, data collection and processing of results were carried out on gamma-cameras of the systems Signature Series, Symbia T16 Siemens, and syngo M1 Applications VB10 Siemens.Parameters of the radioactivity of 99mTc were processed by mathematical methods using the Excel program.Results. We revealed specific factors influencing the OSG capacity: 1) three-hour accumulation of RFP after its administration to the patient; 2) generator activity by days of its operation; 3) the day of the week of the generator delivery. We calculated quantitative indicators of the maximum possible OSG capacity during the generator operation (maximum number of OSG procedures by days of operation, total capacity, preferred day of the week for the generator delivery).Conclusion. The most significant factors in optimal OSG planning by days of the generator operation are the generator specifications, quantity and frequency of generator supply, provision of gamma-cameras.The described technique for scheduling diagnostic procedures can be useful for the efficient use of the generator system which ensures the maximum amount of high-quality RFP from the generator eluate and contributes to the objectification of the cancer process in order to choose the treatment tactics.
Experience of pemetrexed in maintenance therapy for metastatic lung adenocarcinoma
Authors: Vladimirova L. Yu. , Storozhakova A. E. , Kalabanova E. A. , Meshcheryakov P. N. , Oskin S. V. , Kabanov S. N. , Samaneva N. Yu. , Svetitskaya Ya. V. , Tishina A. V. 
Published: March 2021

Lung cancer is among the most common malignant diseases in Russia. In 80–90%, its morphological type is nonsmall cell lung cancer. Stage IV primary advanced lung cancer is diagnosed in 41% of patients. Median overall survival in stage IV patients receiving chemotherapy is 7–12 months. Treatment for stage IV lung adenocarcinoma is based on predictive and prognostic factors. Chemotherapy, chemoimmunotherapy or immunotherapy is recommended in the absence of driver mutations in the EGFR (exons 19 and 21) and BRAF genes, ALK and ROS1 translocations.Platinum- based regimens are preferred as the fi rst-line chemotherapy. Stabilization, partial or complete response after 4–6 chemotherapy cycles allow for maintenance therapy with pemetrexed to increase progression-free survival and overall survival.Purpose of the study. Using a real clinical case, to confirm the efficacy of pemetrexed in the treatment for stage IV lung adenocarcinoma in the second-line therapy in combination with platinum- based agents and in a maintenance therapy.A clinical case of a patient with central cancer of the lower lobe of the right lung St IV (cT3N2M1) is presented; the first treatment stage involved 3 cycles of the fi rst-line polychemotherapy (paclitaxel 175 mg/m² intravenously on day 1, carboplatin AUC 5 intravenously on day 1, every 3 weeks), and 6 cycles of the second-line polychemotherapy (pemetrexed 500 mg/m2 intravenously on day 1, cisplatin 75 mg/m² intravenously on day 1 of the 21-day cycle). Stabilization of the disease was achieves, and 20 cycles of maintenance therapy with pemetrexed followed; the achieved effect persisted and was confirmed by spiral X-ray computed tomography every 3 months. The objective effect of anticancer therapy was assessed according to the RECIST 1.1 criteria. It took 20 months from the beginning of the second-line anticancer medical therapy to progression, and 16 months from the start of maintenance pemetrexed to progression. The safety profile was satisfactory, and the ECOG performance status 0 maintained. Only one adverse effect, degree I general weakness, was noted, which did not have a negative impact on the patient's quality of life.
PERSEPSI SISWA DALAM KEBIJAKAN PEMBELAJARAN JARAK JAUH
Authors: Hidayatulah Muhammad Arif , Astuti Retno Sunu , Simanjuntak Sri Yunita 
Published: March 2021

Pandemi COVID-19 mengubah sistem pembelajaran menjadi pembelajaran jarak jauh atau daring. Ini adalah upaya dari pemerintah untuk mencegah penularan COVID-19 di sektor pendidikan. Penelitian ini bertujuan untuk melihat bagaimana persepsi siswa terhadap kebijakan pembelajaran jarak jauh selama pandemi. Semua pihak saat ini dari mulai staf pengajar dan siswa sedang beradaptasi mmenggunakan berbagai sistem pembelajaran yang tersedia. Penelitian ini merupakan penelitian deskriptif kuantitatif. Teknik pengumpulan data berupa kuisioner yang dibagikan secara online melalui googleform. Responden penelitian ini adalah siswa di tingkat SD/MI dan SMP/MTs di 5 Kabupaten/Kota mitra Tanoto Foundation di Provinsi Kalimantan Timur. Pivoting digunakan sebagai alat analisis data yang digunakan adalah deskripsi persentase. Total responden 222 siswa yang diambil secara acak sederhana. Hasil dari penelitian ini, 98% siswa telah melaksanakan program PJJ; 53% siswa merasa menyenangkan; 47% siswa merasa kurang/tidak nyaman dan dari yang merasa menyenangkan 36% siswa beralasan mendapatkan pengalaman belajar yang bermakna serta dari yang merasa kurang/tidak nyaman 37% siswa beralasan terlalu banyak tugas. Sarana komunikasi yang banyak digunakan adalah whatsapp group, facebook, massenger, serta google classroom sebanyak 96% siswa dan 4% siswa menggunakan video conference; Kendala yang paling banyak dialami yaitu kurangnya kualitas koneksi jaringan internet.
Prélude au soulèvement citoyen du 22 février : la montée des contestations dans les espaces de loyauté du régime
Authors: Bensaâd Ali 
Published: March 2021

Avant que n’éclatent les gigantesques manifestations qui ont secoué le 22 février 2019 les principales villes algériennes, marquant le début du mouvement citoyen appelé Hirak, celles-ci avaient été précédées par des manifestations qui leur serviront de détonateur dans trois villes enclavées de l’intérieur du pays : Ouargla, Kherrata et Khenchela. Les trois villes, malgré le paradoxe apparent de leur enclavement, occupent une position stratégique dans le maillage spatial clientélaire du régime. Chacune d’elles constitue un réservoir de clientèle et un relais avancé pour le régime dans des régions stratégiques, comme composantes à la fois essentielles et particulières de la structuration territoriale de l’État-nation : la Kabylie, les Aurès et le Sahara. Cet article aborde la place clé de ces villes, les rivalités de conceptions et les ambiguïtés de la place qui leur a été assignée dans les constructions territoriales et identitaires de l’État-nation indépendant, les modalités de leur intégration dans le dispositif clientélaire et autoritaire du régime puis le processus de délitement, de subversion et de fissuration de ce dispositif qui a marqué l’effondrement du régime dans ses bases lointaines et la voie ouverte à sa contestation en son centre.
Association between estradiol levels and clinical outcomes of IVF cycles with single blastocyst embryo transfer
Authors: Polim Arie A. , Handayani Nining , Aprilliana Tri , Silvia Roza , Sirait Batara , Boediono Arief , Sini Ivan 
Published: March 2021

Objective:
To determine the correlation of different serum estradiol levels on the trigger day with the clinical and laboratory outcomes of in-vitro fertilization (IVF) cycles comprising a single fresh top-quality blastocyst transfer.

Methods:
This was a retrospective observational study performed in Morula IVF Clinic Jakarta. Five hundred forty-two women were recruited and grouped according to their serum estradiol levels on the trigger day of follicular maturation as follows: <2 000 pg/mL, 2 000-2 999 pg/mL, 3 000-3 999 pg/mL, and ≥ 4 000 pg/mL. Clinical pregnancy and miscarriage rates were evaluated as the primary outcomes and embryology laboratory results as the secondary outcomes which consisted of the number of retrieved, mature, and fertilized oocytes, the total sum of derived embryos, and top-quality embryos at cleavage and blastocyst stage.

Results:
Clinical pregnancy and miscarriage rates did not differ among the groups (P>0.05). Nonetheless, the study demonstrated a positive correlation of the serum estradiol levels with the overall laboratory outcomes including the number of retrieved, mature, and fertilized oocytes, the total sum of derived embryos, and top-quality embryos at cleavage and blastocyst stage (P<0.001). The subject group with estradiol level of ≥4 000 pg/mL was superior to the other groups in its respective median number of retrieved, mature, fertilized oocytes, total derived embryos, and top-quality cleavage- and blastocyst-stage embryos.

Conclusions:
Although an apparent positive correlation is observed between estradiol levels and laboratory outcomes, serum estradiol level on hCG trigger day is not associated with the clinical outcomes of IVF.
Combined effects of Gymnema sylvestre and Pergularia daemia on letrozole-induced polycystic ovarian syndrome in rats
Authors: Pachiappan Sudhakar , Ramalingam Kothai , Balasubramanian Arul 
Published: March 2021

Objective:
To investigate the combined therapeutic potential of Gymnema (G.) sylvestre and Pergularia (P.) daemia on letrozole-induced polycystic ovarian syndrome (PCOS) in rats.

Methods:
Thirty six healthy female Wistar rats with regular estrus cycles were randomly divided into six groups each of 6. Group I received 1 mL of 0.5% carboxyl methyl cellulose orally and served as the vehicle control group, while groups II to VI were treated with letrozole (1 mg/kg body weight p. o.) for 21 days to induce PCOS. After induction of PCOS, group II served as the PCOS control group, without treatment; group III received metformin (20 mg/kg body weight p. o.) as the standard group, and groups IV to VI received G. sylvestre (100 mg/kg body weight p. o.), P. daemia (300 mg/kg body weight p. o.), and the combination of G. sylvestre and P. daemia, respectively, for 28 days. Vaginal smears were collected from all rats daily throughout the study to determine the phases of the estrus cycle. After completing the treatment schedule, oral glucose tolerance test, serum lipid profile and reproductive hormonal analysis were carried out. Subsequently, the rats were sacrificed to collect ovary and uterus for histopathological examination.

Results:
The PCOS control rats showed a significant irregularity in the estrus cycle, hyperglycemia, and the altered serum lipid profile such as the increased low and very low density lipoprotein, triglyceride, and decreased high density lipoproteins. In addition, the PCOS control rats showed a significant increase in serum luteinizing hormone, testosterone, and estrogen, and decrease in follicle stimulating hormone and progesterone. These changes were significantly revoked in all the treatment groups. The test drugs also significantly reduced the gained ovary weight (P<0.001), and histopathology of the ovary showed almost normal ovary. Among the treatment groups, the group of combination treatment of G. sylvestre and P. daemia showed superior ameliorative results in PCOS parameters.

Conclusions:
Combination of G. sylvestre and P. daemia presents potent synergistic activity against hyperandrogenism, hyperinsulinemia, anovulation and follicular cysts in letrozole-induced PCOS rats.
Semen characteristics of the three genetic types of boars reared in Benin
Authors: Dotche Ignace O. , Gakou Aïchatou , Bankolé Constant Boris O.B. , Dahouda Mahamadou , Houaga Isidore , Antoine-Moussiaux Nicolas , Dehoux Jean Paul , Thilmant Pierre , Koutinhouin Benoît G. , Abdou Karim Issaka Youssao Abdou 
Published: March 2021

Objective:
To characterize the semen of three genetic types of boars (local, improved and Large White) reared in Benin.

Methods:
Semen of local, improved and Large White boars reared in Benin were collected using the gloved hand method and analyzed to determine volume, pH, concentration, mobility, motility, and morphology. The effect of the genetic type of boar on semen characteristics was aslo studied.

Results:
Duration of ejaculation and semen volume of Large White boar were significantly higher than those of local and improved boars (P<0.05). The semen of improved boars had a higher motility score than that of Large White and local boars (P<0.001). The semen of local boars was more concentrated in the spermatozoa than that of improved and Large White boars (P<0.05). The proportion of spermatozoa of improved boars with normal morphology (93.6%) was significantly higher than that of local (82.2%) and Large White boars (81.6%) (P<0.001). The proportion of spermatozoa with folded tails in the semen of Large White boars (9.2%) was significantly higher than that observed in improved (1.8%) and local (5.0%) boars (P<0.001). The proportion of spermatozoa with proximal cytoplasmic droplets in semen of improved boars (2.7%) was significantly lower than that in Large White (6.8%) and local (9.7%) boars (P<0.001). The local (1.5%) and Large White boars (1.1%) showed more spermatozoa with distal cytoplasmic droplets in their semen compared to the improved boars (0.4%).

Conclusions:
The semen characteristics of pigs reared in Benin vary from one genetic type to another. Each genetic type has a strong point. The Large White boar produces larger semen, the local boar produces more concentrated semen and the improved boar produces spermatozoa that are morphologically better. The semen of these three genetic types can be used in artificial insemination but the improved boar's semen is more recommended.
Evaluation of pig oocyte in vitro maturation and fertilization using three gonadotropin-based hormonal compounds
Authors: Santiago-Rodriguez Rosario , Alvarez-Guerrero Alma L. , Garcia-Gonzalez Fernando , Alcantar-Rodriguez Alicia , Medrano Alfredo 
Published: March 2021

Objective:
To evaluate the effect of human chorionic gonadotropins (hCG) and equine chorionic gonadotropins (eCG) on in vitro gilt oocyte maturation and embryonic development, using frozen semen for fertilization.

Methods:
Two independent experiments (6 replicates each) were carried out to evaluate gilt oocyte maturation, and fertilization and embryonic development by using ovaries from a local abattoir. Totally, 712 oocytes were randomly distributed in four-well dishes to receive Novormon (eCG 5.0 IU), PG600 (eCG 5.0 IU and hCG 2.5 IU), Chorulon (hCG 5.0 IU), or no hormones. Oocytes were incubated with 5% CO2, 95% air and saturation humidity at 39 °C for 44 h. Maturation of the oocytes to metaphase II was assessed by using the aceto-orcein technique. In addition, 741 oocytes were used and randomly distributed in four-well dishes, and then oocyte maturation was carried out as mentioned, but matured oocytes were washed and placed in fertilization medium with frozen-thawed sperm. Gametes were co-incubated for 7 h, and then washed and placed in development medium, and incubated for further 7 days, at which time embryonic development was evaluated. Fertilization and embryo development media were not supplemented with the studied hormones.

Results:
Novormon (eCG) and PG600 (eCG+hCG) treatments significantly improved the percentages of metaphase II oocytes compared to the control group (P<0.05). Furthermore, a significant increase was also observed in the young blastocyst stage between the control group and the PG600 treatment group (P<0.05).

Conclusions:
Hormonal products Novormon (eCG) and PG600 (eCG+hCG) can obtain the highest percentages of in vitro maturation in gilt oocytes; however, this effect is not transferred to fertilization rates.