bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating Anatomical, Molecular and Clinical Risk Factors in Gastrointestinal Stromal Tumor of the Stomach
Authors: Hølmebakk Toto , Wiedswang Anne Marit , Meza-Zepeda Leonardo A. , Hompland Ivar , Lobmaier Ingvild V. K. , Berner Jeanne-Marie , Stoldt Stephan , Boye Kjetil 
Published: March 2021

Abstract
Background
Adjuvant imatinib for 3 years is recommended to patients with high-risk gastrointestinal stromal tumor (GIST). Risk stratification is inaccurate, and risk assessments are further complicated by the increased use of neoadjuvant treatment. Anatomical criteria for prognostication have not been investigated.

Methods
Clinical, molecular, and anatomical variables were retrospectively studied in a population-based cohort of 295 patients with gastric GIST resected between 2000 and 2018. Gastric subsite was divided into the upper, middle, and lower thirds. Growth pattern was classified as luminal, exophytic, or transmural based on imaging and surgical reports.

Results
Of 113 tumors in the upper third of the stomach, 103 (91.2%) were KIT mutated, 7 (6.2%) were PDGFRA mutated, and 104 (92.0%) harbored genotypes sensitive to imatinib. Transmural tumors were strongly associated with a high mitotic index. Five-year recurrence-free survival (RFS) was 71% for patients with transmural tumors versus 96% with luminal or exophytic tumors (hazard ratio [HR] 8.45, 95% confidence interval [CI] 3.69–19.36; p < 0.001), and, in high-risk patients, 5-year RFS was 46% for patients with transmural tumors versus 83% with luminal or exophytic tumors (HR 4.47, 95% CI 1.71–11.66; p = 0.001). Among 134 patients with tumors > 5 cm, there were 29 recurrences. Only five patients with exophytic or luminal tumors had recurrent disease, of whom four had tumor rupture. Five-year RFS for patients with exophytic/luminal tumors >5 cm without rupture was 98%.

Conclusions
In the upper third, over 90% of tumors were sensitive to imatinib. Patients with exophytic or luminal tumors without rupture, irrespective of size, had an excellent prognosis and may not benefit from adjuvant therapy.
Revised estimates of leprosy disability weights for assessing the global burden of disease: A systematic review and individual patient data meta-analysis
Authors: Nanjan Chandran Shri Lak , Tiwari Anuj , Lustosa Anselmo Alves , Demir Betul , Bowers Bob , Albuquerque Rachel Gimenes Rodrigues , Prado Renata Bilion Ruiz , Lambert Saba , Watanabe Hiroyuki , Haagsma Juanita , Richardus Jan Hendrik 
Published: March 2021

Background
Leprosy is a chronic bacterial infection caused by Mycobacterium leprae, which may lead to physical disability, stigma, and discrimination. The chronicity of the disease and disabilities are the prime contributors to the disease burden of leprosy. The current figures of the disease burden in the 2017 global burden of disease study, however, are considered to be under-estimated. In this study, we aimed to systematically review the literature and perform individual patient data meta-analysis to estimate new disability weights for leprosy, using Health-Related Quality of Life (HRQOL) data.

Methodology/principal findings
The search strategy included all major databases with no restriction on language, setting, study design, or year of publication. Studies on human populations that have been affected by leprosy and recorded the HRQOL with the Short form tool, were included. A consortium was formed with authors who could share the anonymous individual-level data of their study. Mean disability weight estimates, sorted by the grade of leprosy disability as defined by WHO, were estimated for individual participant data and pooled using multivariate random-effects meta-analysis. Eight out of 14 studies from the review were included in the meta-analysis due to the availability of individual-level data (667 individuals). The overall estimated disability weight for grade 2 disability was 0.26 (95%CI: 0.18–0.34). For grade 1 disability the estimated weight was 0.19 (95%CI: 0.13–0.26) and for grade 0 disability it was 0.13 (95%CI: 0.06–0.19). The revised disability weight for grade 2 leprosy disability is four times higher than the published GBD 2017 weights for leprosy and the grade 1 disability weight is nearly twenty times higher.

Conclusions/significance
The global burden of leprosy is grossly underestimated. Revision of the current disability weights and inclusion of disability caused in individuals with grade 0 leprosy disability will contribute towards a more precise estimation of the global burden of leprosy.
Use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers associated with lower risk of COVID-19 in household contacts
Authors: Armstrong Katrina , Soltoff Alex , Rieu-Werden Meghan , Metlay Joshua , Haas Jennifer 
Published: March 2021

Background
Use of angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) has been hypothesized to affect COVID-19 risk.

Objective
To examine the association between use of ACEI/ARB and household transmission of COVID-19.

Methods
We conducted a modified cohort study of household contacts of patients who tested positive for COVID-19 between March 4 and May 17, 2020 in a large Northeast US health system. Household members were identified by geocoding and full address matching with exclusion of addresses with >10 matched residents or known congregate living functions. Medication use, clinical conditions and sociodemographic characteristics were obtained from electronic medical record (EMR) data on cohort entry. Cohort members were followed for at least one month after exposure to determine who tested positive for SARS-CoV-2. Mixed effects logistic regression and propensity score analyses were used to assess adjusted associations between medication use and testing positive.

Results
1,499 of the 9,101 household contacts were taking an ACEI or an ARB. Probability of COVID-19 diagnosis during the study period was slightly higher among ACEI/ARB users in unadjusted analyses. However, ACEI/ARB users were older and more likely to have clinical comorbidities so that use of ACEI/ARB was associated with a decreased risk of being diagnosed with COVID-19 in mixed effect models (OR 0.60, 95% CI 0.44–0.81) or propensity score analyses (predicted probability 18.6% in ACEI/ARB users vs. 24.5% in non-users, p = 0.03). These associations were similar within age and comorbidity subgroups, including patients with documented hypertension, diabetes or cardiovascular disease, as well as when including other medications in the models.

Conclusions
In this observational study of household transmission, use of ACEIs or ARBs was associated with a decreased risk of being diagnosed with COVID-19. While causality cannot be inferred from these observational data, our results support current recommendations to continue ACEI/ARB in individuals at risk of COVID-19 exposure.
Nutritional status and TB treatment outcomes in Addis Ababa, Ethiopia: An ambi-directional cohort study
Authors: Sahile Zekariyas , Tezera Robel , Haile Mariam Damen , Collins Jeffrey , Ali Jemal Haider 
Published: March 2021

Background
Remaining underweight during Tuberculosis (TB) treatment is associated with a higher risk of unsuccessful TB treatment outcomes and relapse. Previous studies conducted in Ethiopia found that bodyweight not adjusted for height at the start of treatment is associated with poor treatment outcomes. However, the association of body mass index (BMI) and weight change during treatment with treatment outcomes has not been studied. We aimed to investigate the association of BMI at the time of diagnosis and after two months of treatment and TB treatment outcomes.

Methods
Using an ambi-directional cohort study design (retrospective and prospective), a total of 456 participants were enrolled among 30 randomly selected public health centers residing within six sub-cities of Addis Ababa, Ethiopia. Data were collected using medical chart abstraction and face to face interviews. We compared TB treatment outcomes in persons with a body mass index (BMI) <18.5kg/m2 (underweight) versus persons with BMI ≥18.5kg/m2 (normal or overweight) at treatment initiation and after two months of treatment. Treatment was classified as successful in persons who were free of symptoms and had a negative sputum smear for acid-fast bacilli at the end of the 6-month treatment course. We analysed outcomes using univariable and multivariable logistic regression with 95% CI and p value< 0.05.

Results
Of enrolled study participants, 184 (40.4%) were underweight and 272 (59.6%) were normal or overweight. Body mass index (BMI ≥18.5kg/m2) at the start and second month of treatment were independent predictors for successful treatment outcome (AOR = 2.15; 95% CI: 1.05, 4.39) and (AOR = 3.55; 95% CI: 1.29, 9.73), respectively. The probability of treatment success among patients with BMI≥18.5kg/m2 at the start and second month of treatment was 92.9% and 97.1%, respectively versus 86.5% and 91.7% in patients with BMI<18.5kg/m2. Bodyweight not adjusted for height and change in the bodyweight after the second and sixth months of treatment were not significantly associated with treatment success.

Conclusion
In persons treated for TB disease, being underweight at baseline and after two months of treatment was a predictor for unsuccessful treatment outcomes. Nutritional assessment, counselling, and management are important components of TB treatment programs with the potential to improve treatment outcomes.
Reciprocal constructions in Homeric Greek: A typological and corpus-based approach
Authors: Inglese Guglielmo , Zanchi Chiara 
Published: March 2021

Abstract
Ancient Greek features a wide array of means to encode reciprocity. Even though reference grammars do mention most of these strategies, they have not been brought together and compared in a systematic way so far. In this paper, we provide a thorough corpus-based description of the three most widespread reciprocal markers in Homeric Greek: the pronoun allḗlōn, the middle voice, and the use of preverbs. Our analysis is couched within current descriptive models of reciprocal constructions developed in linguistic typology. As we argue, Homeric Greek offers a remarkably complex picture, whereby these strategies synchronically cover different semantic and syntactic sub-domains of reciprocity, and thus partly stand in complementary distribution. Already in Homer, the pronoun allḗlōn is the most productive marker of reciprocal situations, with the middle voice and preverbs playing a more limited role. By adopting a diachronic perspective, we also show that this distribution can partly be explained as the result of the different historical sources of each construction. Moreover, once properly scrutinized, the facts of Homeric Greek provide interesting cues as to the developments of reciprocal constructions in later stages of Greek.
Editorial: The Privatization of Work-Related Risk Control
Authors: Mascini Peter , Veen Romke van der 
Published: March 2021

Abstract
This introduction starts by linking the privatization of work-related risk control to a political context in which social investment policies are prominent. Subsequently, a short overview of different forms of privatization is given. Finally, the different contributions to this special issue are introduced by either relating them to the governance or the consequences of privatization. Based on the contributions to the special issue, it is concluded first that the governance of privatized risk control poses difficult challenges of finding the right balance between public objectives and the involvement of private interests. Secondly, it is concluded that, by excluding or marginalizing the most vulnerable group, the privatization of risk control does not always achieve the equality of opportunities that social investment policies aim for. These risks of exclusion and marginalization seem to be particularly salient when the privatization of social investment policies is embedded in a context of retrenchment or a dualization of the labor market.
Examining the role of and value placed on trusted advisors as viewed by the Chief Executive Officer: A case study on the trusted advisor
Authors: Price Andrea 
Published: March 2021

Given its proximity to and relationship with the C-suite, the role of the trusted advisor is one that many professionals, both within and outside public relations management, aspire to. Perhaps it is for this reason that the trusted advisor, particularly as it relates to the role of the Chief Communication Officer, has received considerable attention in public relations research and academic literature. However, there appears to be a gap in the body of knowledge about the trusted advisor role from the perspective of the Chief Executive Officer. Accordingly, the purpose of this research study was to explore the value of trusted advisors as perceived by the CEO. Through interviews with five chief executives, this study provides insight into the overall nature and role of the trusted advisor relationship: how the individuals came to be trusted advisors; the qualities and abilities that made them suited to the role; and how the CEOs engage with and rely on them. These insights are viewed in relation to the literature on relationship management, the concept of trust, and the roles of the Chief Executive Officer and trusted advisor. The findings indicate that the CEOs saw trust as a critical and foundational element of the relationship. It is also evident that the trusted advisors were relied upon to provide direct and honest feedback. This includes the ability to challenge the perspectives of the CEO, which contributes to building a relationship based on mutual trust.

Keywords: Chief Executive Officer, trusted advisor, relationships, relationship theory, trust, value
A cultural aperture: An inter-provincial analysis of FNMI representation in Canadian news dailies
Authors: Way Michael John 
Published: March 2021

This study acts as a multi-disciplinary contribution to existing research in discourses of news production practices, and representation of First Nations, Métis, and Inuit (FNMI) issues and protest. Specifically, quantitative and qualitative research methods were employed to explore FNMI representation across three mainstream Canadian dailies leading to and following the Idle No More (INM) movement from October 1, 2012 until February 28, 2013. In doing so, the study acts as a longitudinal confirmation of previous studies, revealing minimal FNMI salience during “everyday” news cycles, a narrow range of key topics, and a drastic increase in coverage during times of protest.

Keywords: protest coverage, FNMI media representation, media bias, agenda-setting, uses and gratifications theory, Idle No More, news framing
Positive Effects of Pre-exercise Metabolic Alkalosis on Perceived Exertion and Post-exercise Squat Jump Performance in World-Class Cyclists
Authors: Thomas Claire , Delfour-Peyrethon Rémi , Dorel Sylvain , Hanon Christine 
Published: March 2021

Abstract
Thomas, C, Delfour-Peyrethon, R, Dorel, S, and Hanon, C. Positive effects of pre-exercise metabolic alkalosis on perceived exertion and post-exercise squat jump performance in world-class cyclists. J Strength Cond Res 36(9): 2602–2609, 2022—This study aimed to determine the effects of pre-exercise alkalosis in world-class cyclists on their general (rate of perceived exertion [RPE]) and local (category-ratio scale [CR10]) perceived rates of exertion and acid-base status during 2 types of training sessions. Eight world-class cyclists ingested either sodium bicarbonate (BIC) or a placebo (PLA) in a double-blind and randomized order before performing 4 × 1,000 m constant-power sprints (CP) or 3 × 500 m all-out sprints (AO), with 20 minutes of recovery time between each session. For AO, the performance was assessed through the cycling sprint velocity and a squat jump test during recovery. During both tests, RPE, CR10, and acid-base status were measured. Sodium bicarbonate ingestion was effective in inducing pre-exercise alkalosis, compared with a PLA (p < 0.05). During CP, performance and RPE were the same for BIC and PLA (p > 0.05) with no time effect. The CR10 increased for the last sprint in PLA (p < 0.05) but was attenuated in BIC (BIC: 6 vs. PLA: 8.2; p < 0.05), whereas there was no difference in acid-base status. During AO, RPE and CR10 increased with time, with no BIC effect, whereas blood lactate concentration was different (p < 0.05). Sodium bicarbonate supplementation had no effect on overall repeated sprints (p > 0.05). However, world-class athletes responded to BIC with higher squat jump performance than the PLA condition after AO (p < 0.05). Our results suggest a positive influence of pre-exercise alkalosis in world-class cyclists on local perception of efforts after constant load sprints and an attenuation of muscle power output decline postsprint, as evidenced by improved squat jump performance after all-out cycling effort.
Relationship Between Movement Quality and Physical Performance in Elite Adolescent Australian Football Players
Authors: Bennett Hunter , Fuller Joel , Milanese Steve , Jones Stephen , Moore Emma , Chalmers Samuel 
Published: March 2021

Abstract
Bennett, H, Fuller, J, Milanese, S, Jones, S, Moore, E, and Chalmers, S. The relationship between movement quality and physical performance in elite adolescent Australian football players. J Strength Cond Res 36(10): 2824–2829, 2022—The assessment of movement quality is commonplace in competitive sport to profile injury risk and guide exercise prescription. However, the relationship between movement quality scores and physical performance measures is unclear. Moreover, whether improvements in these measures are associated remain unknown. Over a 4-year period, 918 individual elite adolescent Australian Rules Footballers completed the Functional Movement Screen (FMS) and physical performance testing (5- and 20-m sprint, vertical jump, planned agility, and 20-m shuttle run test), allowing the analysis of relationships between FMS parameters and performance measures. In addition, 235 athletes completed testing over 2 consecutive years, allowing the analysis of relationships between changes in these outcomes. Small associations were observed between FMS composite score, hurdle step performance, in-line lunge performance, trunk stability push-up performance, rotary stability, and measures of speed, power, agility, and aerobic fitness (ρ = 0.071–0.238). Across consecutive seasons, significant improvements were observed in the deep squat subtest (d = 0.21), FMS composite score (d = 0.17), and 5- (d = 0.16) and 20-m sprint times (d = 0.39). A negative association between change in rotary stability and change in jump height (ρ = −0.236) from one season to the next was detected. Results suggest FMS scores have limited relationships with measures of performance in footballers. To optimize athletic performance, once acceptable movement capabilities have been established, training should not prioritize improving movement quality over improvements in strength, power, and change of direction ability.
Comparisons of Daily Energy Intake vs. Expenditure Using the GeneActiv Accelerometer in Elite Australian Football Athletes
Authors: Salagaras Brie S. , Mackenzie-Shalders Kristen L. , Nelson Maximillian J. , Fraysse Francois , Wycherley Thomas P. , Slater Gary J. , McLellan Chris , Kumar Kuldeep , Coffey Vernon G. 
Published: March 2021

Abstract
Salagaras, BS, Mackenzie-Shalders, KL, Nelson, MJ, Fraysse, F, Wycherley, TP, Slater, GJ, McLellan, C, Kumar, K, and Coffey, VG. Comparisons of daily energy intake vs. expenditure using the GeneActiv accelerometer in elite Australian Football athletes. J Strength Cond Res 35(5): 1273–1278, 2021—To assess validity of the GeneActiv accelerometer for use within an athlete population and compare energy expenditure (EE) with energy and macronutrient intake of elite Australian Football athletes during a competition week. The GeneActiv was first assessed for utility during high-intensity exercise with indirect calorimetry. Thereafter, 14 professional Australian Football athletes (age, 24 ± 4 [SD] y; height, 1.87 ± 0.08 m; body mass, 86 ± 10 kg) wore the accelerometer and had dietary intake assessed via dietitian-led 24-hour recalls throughout a continuous 7 days of competition period (including match day). There was a significant relationship between metabolic equivalents and GeneActiv g·min−1 (SEE 1.77 METs; r
2 = 0.64; p < 0.0001). Across the in-season week a significant difference only occurred on days 3 and 4 (day 3: energy intake [EI] EI 137 ± 31 kJ·kg−1·d−1; 11,763 ± 2,646 kJ·d−1 and EE: 186 ± 14 kJ·kg−1·d−1; 16,018 ± 1973 kJ·d−1; p < 0.05; d = −1.4; day 4: EI: 179 ± 44 kJ·kg−1·d−1, 15,413 ± 3,960 kJ·d−1 and EE: 225 ± 42 kJ·kg−1·d−1; 19,313 ± 3,072 kJ·d−1; d = −0.7). Carbohydrate intake (CI) was substantially below current sports nutrition recommendations on 6 of 7 days with deficits ranging from −1 to −7.2 g·kg−1·d−1 (p < 0.05), whereas daily protein and fat intake was adequate. In conclusion, the GeneActiv provides effective estimation of EE during weekly preparation for a professional team sport competition. Australian Footballers attempt to periodize dietary EI to varying daily training loads but fail to match expenditure on higher-training load days. Specific dietary strategies to increase CI may be beneficial to achieve appropriate energy balance and macronutrient distribution, particularly on days where athletes undertake multiple training sessions.
Training, Supplementation, and Pharmacological Practices of Competitive Male Bodybuilders Across Training Phases
Authors: Hackett Daniel A. 
Published: March 2021

Abstract
Hackett, DA. Training, supplementation, and pharmacological practices of competitive male bodybuilders across training phases. J Strength Cond Res 36(4): 963–970, 2022—Bodybuilding involves the pursuit of muscularity and leanness primarily through the use of progressive resistance training in combination with other practices such as manipulation of diet and use of ergogenic aids. This study aimed to compare the training practices and ergogenic aids used by competitive male bodybuilders across training phases. An online survey was completed by 235 competitive male bodybuilders with a median age of 26.0 (interquartile range 23.0–31.3) years. Results showed that most respondents performed split-routines (85.5%), 4–7 sessions per week (95.7%), trained major muscle groups twice a week (>50%), and session duration being 60–90 minutes (55.7%). Off-season resistance training sessions mostly comprised of targeting 2–3 muscle groups (56%), 2–3 exercises per muscle group (60.4%), 3–4 sets per exercise (73.2%), 7–12 repetition maximum (RM) per set (71.6%), and 61–180 seconds recovery between sets and exercises (80.5%). At the precompetition phase (6 weeks before competition), there was a decrease in the number of muscle groups trained per session (p = 0.027) and a greater number of repetitions performed per set (p < 0.001). A significant increase in the reported aerobic exercise volume was found during precompetition (<0.001). Performance enhancing drugs were used by 53.6% of respondents who did not compete in natural bodybuilding competitions. Dietary supplements were used by 95.7% of respondents with the most common being creatine monohydrate (80.4%) and whey protein (65.8%). Findings suggest that competitive bodybuilders follow resistance training practices consistent with the broad muscular hypertrophy recommendations but a notable shift in practices occur in the weeks before competition.