bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suspended sediment load prediction in consecutive stations of river based on ensemble pre-post-processing kernel based approaches
Authors: Ghasempour Roghayeh , Roushangar Kiyoumars , Sihag Parveen 
Published: March 2021

Abstract
Sediment transportation and accurate estimation of its rate is a significant issue for river engineers and researchers. In this study, the capability of kernel based approaches including Kernel Extreme Learning Machine (KELM) and Gaussian Process Regression (GPR) was assessed for predicting the river daily Suspended Sediment Discharge (SSD). For this aim, the Mississippi River, with three consecutive hydrometric stations, was selected as the case study. Based on the sediment and flow characteristics during the period of 2005–2008, several models were developed and tested under two scenarios (i.e. modeling based on each station's own data or the previous stations' data). Two post-processing techniques, namely Wavelet Transform (WT) and Ensemble Empirical Mode Decomposition (EEMD), were used for enhancing the SSD modeling capability. Also, data post-proceeding was done using Simple Linear Averaging (SLAM) and Nonlinear Kernel Extreme Learning Machine Ensemble (NKELME) methods. Obtained results indicated that the integrated models resulted in more accurate outcomes. Data processing enhanced the models' capability up to 35%. It was found that SSD modeling based on the station's own data led to better results; however, using the integrated approaches, the previous station's data could be applied successfully for the SSD modeling when a station's own data were not available.
Protein-Ligand Docking Simulations with AutoDock4 Focused on the Main Protease of SARS-CoV-2
Authors: de Azevedo Junior Walter Filgueira , Bitencourt-Ferreira Gabriela , Godoy Joana Retzke , Adriano Hilda Mayela Aran , dos Santos Bezerra Wallyson André , dos Santos Soares Alexandra Martins 
Published: March 2021

Background:
The main protease of SARS-CoV-2 (Mpro) is one of the targets
identified in SARS-CoV-2, the causative agent of COVID-19. The application of X-ray
diffraction crystallography made available the three-dimensional structure of this protein
target in complex with ligands, which paved the way for docking studies.

Objective:
Our goal here is to review recent efforts in the application of docking simulations
to identify inhibitors of the Mpro using the program AutoDock4.

Methods:
We searched PubMed to identify studies that applied AutoDock4 for docking
against this protein target. We used the structures available for Mpro to analyze intermolecular
interactions and reviewed the methods used to search for inhibitors.

Results:
The application of docking against the structures available for the Mpro found ligands
with an estimated inhibition in the nanomolar range. Such computational approaches
focused on the crystal structures revealed potential inhibitors of Mpro that might exhibit
pharmacological activity against SARS-CoV-2. Nevertheless, most of these studies lack
the proper validation of the docking protocol. Also, they all ignored the potential use of
machine learning to predict affinity.

Conclusion:
The combination of structural data with computational approaches opened
the possibility to accelerate the search for drugs to treat COVID-19. Several studies used
AutoDock4 to search for inhibitors of Mpro. Most of them did not employ a validated
docking protocol, which lends support to critics of their computational methodology. Furthermore,
one of these studies reported the binding of chloroquine and hydroxychloroquine
to Mpro. This study ignores the scientific evidence against the use of these antimalarial
drugs to treat COVID-19.
Withdrawal Notice: Detection of Viruses and development of new treatments: Insights into Antibody-Antigen Interactions and Multifunctional Lab-On-Particle for SARS CoV-2
Authors: Bracamonte A. Guillermo , Amé Martin , Abu Serea Esraa Samy , Shalan Ahmed Esmail 
Published: March 2021

The article has been withdrawn at the request of the author and the editor of the journal Coronaviruses, due to incoherent language.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:
It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit- ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
A Framework (SOCRATex) for Hierarchical Annotation of Unstructured Electronic Health Records and Integration Into a Standardized Medical Database: Development and Usability Study
Authors: Park Jimyung , You Seng Chan , Jeong Eugene , Weng Chunhua , Park Dongsu , Roh Jin , Lee Dong Yun , Cheong Jae Youn , Choi Jin Wook , Kang Mira , Park Rae Woong 
Published: March 2021

Background
Although electronic health records (EHRs) have been widely used in secondary assessments, clinical documents are relatively less utilized owing to the lack of standardized clinical text frameworks across different institutions.

Objective
This study aimed to develop a framework for processing unstructured clinical documents of EHRs and integration with standardized structured data.

Methods
We developed a framework known as Staged Optimization of Curation, Regularization, and Annotation of clinical text (SOCRATex). SOCRATex has the following four aspects: (1) extracting clinical notes for the target population and preprocessing the data, (2) defining the annotation schema with a hierarchical structure, (3) performing document-level hierarchical annotation using the annotation schema, and (4) indexing annotations for a search engine system. To test the usability of the proposed framework, proof-of-concept studies were performed on EHRs. We defined three distinctive patient groups and extracted their clinical documents (ie, pathology reports, radiology reports, and admission notes). The documents were annotated and integrated into the Observational Medical Outcomes Partnership (OMOP)-common data model (CDM) database. The annotations were used for creating Cox proportional hazard models with different settings of clinical analyses to measure (1) all-cause mortality, (2) thyroid cancer recurrence, and (3) 30-day hospital readmission.

Results
Overall, 1055 clinical documents of 953 patients were extracted and annotated using the defined annotation schemas. The generated annotations were indexed into an unstructured textual data repository. Using the annotations of pathology reports, we identified that node metastasis and lymphovascular tumor invasion were associated with all-cause mortality among colon and rectum cancer patients (both P=.02). The other analyses involving measuring thyroid cancer recurrence using radiology reports and 30-day hospital readmission using admission notes in depressive disorder patients also showed results consistent with previous findings.

Conclusions
We propose a framework for hierarchical annotation of textual data and integration into a standardized OMOP-CDM medical database. The proof-of-concept studies demonstrated that our framework can effectively process and integrate diverse clinical documents with standardized structured data for clinical research.
Impact of Firearm Surveillance on Gun Control Policy: Regression Discontinuity Analysis
Authors: Post Lori , Mason Maryann , Singh Lauren Nadya , Wleklinski Nicholas P , Moss Charles B , Mohammad Hassan , Issa Tariq Z , Akhetuamhen Adesuwa I , Brandt Cynthia A , Welch Sarah B , Oehmke James Francis 
Published: March 2021

BackgroundPublic mass shootings are a significant public health problem that require ongoing systematic surveillance to test and inform policies that combat gun injuries. Although there is widespread agreement that something needs to be done to stop public mass shootings, opinions on exactly which policies that entails vary, such as the prohibition of assault weapons and large-capacity magazines.ObjectiveThe aim of this study was to determine if the Federal Assault Weapons Ban (FAWB) (1994-2004) reduced the number of public mass shootings while it was in place.MethodsWe extracted public mass shooting surveillance data from the Violence Project that matched our inclusion criteria of 4 or more fatalities in a public space during a single event. We performed regression discontinuity analysis, taking advantage of the imposition of the FAWB, which included a prohibition on large-capacity magazines in addition to assault weapons. We estimated a regression model of the 5-year moving average number of public mass shootings per year for the period of 1966 to 2019 controlling for population growth and homicides in general, introduced regression discontinuities in the intercept and a time trend for years coincident with the federal legislation (ie, 1994-2004), and also allowed for a differential effect of the homicide rate during this period. We introduced a second set of trend and intercept discontinuities for post-FAWB years to capture the effects of termination of the policy. We used the regression results to predict what would have happened from 1995 to 2019 had there been no FAWB and also to project what would have happened from 2005 onward had it remained in place.ResultsThe FAWB resulted in a significant decrease in public mass shootings, number of gun deaths, and number of gun injuries. We estimate that the FAWB prevented 11 public mass shootings during the decade the ban was in place. A continuation of the FAWB would have prevented 30 public mass shootings that killed 339 people and injured an additional 1139 people.ConclusionsThis study demonstrates the utility of public health surveillance on gun violence. Surveillance informs policy on whether a ban on assault weapons and large-capacity magazines reduces public mass shootings. As society searches for effective policies to prevent the next mass shooting, we must consider the overwhelming evidence that bans on assault weapons and/or large-capacity magazines work.
GASTO PÚBLICO Y CRECIMIENTO EN AMÉRICA LATINA: LA LEY DE WAGNER Y LA HIPÓTESIS DE KEYNES
Authors: Ramírez Cedillo Eduardo , López Herrera Francisco 
Published: March 2021

<p>Se analiza la relación del crecimiento económico con el gasto público de 16 países latinoamericanos de 1990 a 2017. Este trabajo contribuye a la literatura sobre el tema enfocándose en la región. Los resultados de un modelo para paneles cointegrados respaldan la ley de Wagner en el largo plazo y brindan evidencia parcial a favor de las hipótesis de Keynes en el corto plazo.</p><p><strong> </strong></p><p align="center">PUBLIC SPENDING AND GROWTH IN LATIN AMERICA:</p><p align="center">WAGNER´S LAW AND KEYNES’S HYPOTHESIS<strong></strong></p><p align="center"><strong>ABSTRACT</strong></p><p>The relationship between economic growth and public spending in 16 Latin American countries from 1990 to 2017 is analyzed. This paper contributes to the literature on the subject focusing on the region. The results from a model of cointegrated panels support Wagner’s Law in the long term and provides partial evidence in favor of the Keynesian hypotheses in the short term.</p>
Etiological and epidemiological characteristics of infectious hemocolitis in hospitalized pediatric patients
Authors: Klimova O. I. , Gonchar N. V. , Razd’yakonova I. V. , Lobzin Yu. V. 
Published: March 2021

The aim of this work is to study the etiological and epidemiological features of infectious hemocolites (IG) in hospitalized children of different ages.Materials and methods of research. An analysis of the results of a survey of 3103 children admitted to hospital treatment for acute intestinal infections (AII) from January to December 2018, among which patients with IG were identified. The etiology of the disease was determined based on the results of the bacteriological method, PCR studies of faeces with Amplicens ® OKI screen-FL reagents, serological and immunological methods. Microscopic examination of faeces was performed to identify protozoa. Patients were divided into age groups: infant (n=78; 30%); early (n=74; 28,5%); preschool (n=63; 24,2%), school (n=45; 17,3%).Results. The incidence of IG in hospitalized children with AII was 8,4%. Bacterial pathogens of IG were detected in 66,5% of children, IG of unspecified etiology was diagnosed in 24,2%. Viral and bacterial infections were rarely detected (9,2%). Among intestinal viruses, rotavirus (37,5%), norovirus (29,2%) and enterovirus (20,8%) were more frequently detected in hemocolitis of combined viral and bacterial etiology. In the IG age structure, infants (30%), young children (28,5%) and pre-school children (24,2%) made up the majority. The maximum number of IG patients was detected in the summer (10,9% of all cases of AII). Salmonellosis was more often detected in autumn (31,6%), campylobacteriosis – in summer (17.9%) and autumn (24,1%), escherichiosis and shigellosis – in summer (11,5% and 6,4%, respectively). The maximum detection of IG in infants was observed in June (14,1%) and October (12,8%), in young children – in July (17,6%), in preschoolers – in June (12,7%) and November (15,9%), in schoolchildren in May (13,3% of cases) and in October (15,6%).Conclusion. The incidence of infectious hemocolites in hospitalized children with acute intestinal infections was 8,4%. The bacterial etiology of the disease was detected in 66,5% of children. The age structure of the IG was dominated by children of infant, early and preschool age. The maximum detection of patients with IG was observed in the summer.
KONSEP DAKWAH KULTURAL NAHDLATUL ‘ULAMÂ
Authors: Nuryani Nuryani , Syufa’at M. Ali , Fajar M. Samson 
Published: March 2021

Nahdlatul ‘Ulamâ sebagai sebuah jamiyyah dhiniyyah yang berhaluan faham Ahlussunnah wal Jamaah merupakan organisasi terbesar di Indonesia yang didirikan oleh KH. Hasyim Asy’ari pada 16 Rajab 1344 H / 31 Januari 1926. Dalam dakwahnya Nahdlatul ‘Ulamâ menggunakan metode dakwah Cultural, seperti halnya dakwah yang dipraktikkan Wali Songo. Nahdlatul al-‘Ulamâ memperkuat pendekatan budaya sebagai salah satu elemen penting dakwah Islam ditanah air. Penelitian ini merupakan penelitian kualitatif yang membahas tentang metode dakwah kultural Nahdlatul al-Ulamâ. Adapun macam-macam metode dakwah Nahdlatul ‘Ulamâ diantaranya adalah berceramah, propaganda, pendidikan, kelembagaan, keteladanan, kesenian, diskusi, tanya jawab, bimbingan konseling, karya tulis, korespondensi, silaturahmi. Adapun Strategi dakwah Nahdlatul al-‘Ulamâ yaitu melalui pembudayaan nilai-nilai Islam dengan menggunakan perangkat budaya lokal sebagai instrumen dakwahnya. Dalam pandangan kaum Nahdliyin kehadiran Islam yang dibawa oleh Rosulullah SAW. Bukanlah untuk menolak tradisi yang telah berlaku dan mengakar menjadi kultur kebudayaan masyarakat, melainkan sekedar untuk melakukan pembenahan dan pelurusan terhadap tradisi dan budaya yang tidak sesuai dengan risalah Rosulullah.
Repensar el “Proceso”. Debates en torno a la dictadura y sus vínculos con el presente
Authors: Estermann Victoria 
Published: March 2021

Reseña de: The Argentinian Dictatorship and its Legacy. Rethinking the Proceso de Juan Grigera y Luciana Zorzoli (editores), Palgrave Macmillan, 2019, 213 págs.
TINGKAT KERENTANAN PESISIR DI UTARA DAN TIMUR PULAU BINTAN PROVINSI KEPULAUAN RIAU TAHUN 2020
Authors: Suhana Mario Putra , Putra Risandi Dwirama , Shafitri Leica Febby , Muliadi Muhamad , Khairunnisa Khairunnisa , Nurjaya I Wayan , Natih Nyoman Metta N. 
Published: March 2021

Wilayah pesisir sangat unik, dinamis, dan kompleks karena merupakan zona interaksi antara daratan, lautan, dan atmosfer. Hal ini menjadikan wilayah pesisir sebagai wilayah yang paling rentan di Bumi. Untuk mengetahui seberapa besar kerentanan di suatu wilayah pesisir, perlu dilakukan penelitian untuk mengetahui tingkat kerentanan wilayah pesisir dan faktor yang mempengaruhi. Penelitian mengenai tingkat kerentanan pesisir di lokasi ini pernah dilakukan pada tahun 2016 dan diperoleh simpulan bahwa tingkat kerentanan pesisir berada pada kategori sedang. Dengan semakin berkembangnya pemanfaatan potensi di daerah tersebut maka dirasa perlu dilakukan penelitian serupa dengan tahun 2016 untuk mengetahui apakah terdapat perubahan tingkat kerentanan antara tahun 2016 dengan tahun 2020. Data-data yang digunakan terdiri dari Data-data yang digunakan terdiri dari geomorfologi pantai, pasang surut, citra satelit Landsat 7 ETM+ dan 8 OLI, kenaikan muka laut dan DEM. Analisis data menggunakan metode Coastal Vulnerability Index (CVI). Hasil penelitian menunjukkan tingkat kerentanan pesisir di lokasi penelitian berada pada kategori rendah-sedang, dengan kisaran skor CVI 9,93-25,86. Topografi, geomorfologi, intensitas perubahan garis pantai, dan kemiringan pantai merupakan faktor yang dapat menyebabkan tingkat kerentanan di lokasi penelitian menjadi sangat tinggi. Namun, keterhubungan antara parameter lain yang dapat menjadi faktor penghambat tingginya tingkat kerentanan, menyebabkan tingkat kerentanan pesisir di lokasi penelitian hanya berada dalam kategori rendah-sedang. Terdapat perubahan kondisi tingkat kerentanan antara tahun 2016 dengan tahun 2020 dimana pada tahun 2020 tingkat kerentanan di pantai timur mengalami penurunan menjadi kategori rendah.
Glucagonoma: how the misdiagnosis of a paraneoplastic cutaneous manifestation affects the clinical outcome: a case report
Authors: Parlagreco Elena , Persano Irene , Salvia Anna La , Pia Anna , Scagliotti Giorgio Vittorio , Brizzi Maria Pia 
Published: March 2021

Background:
Glucagonoma is a rare functional pancreatic neuroendocrine tumor. Necrolytic migratory erythema (NME) is a paraneoplastic manifestation of glucagonoma and is often the first presenting symptom. The misdiagnosis of this rare entity can affect the patient’s quality of life and his life expectancy.

Case Presentation:
We report a case of a 48-year-old man presenting with pruritic scaly rash, ulcerated skin lesions, and periorbital edema, who was diagnosed and treated for atopic eczema for a 7-year period. Despite treatment, his dermatitis and general conditions progressively worsened, until he was admitted to the emergency department due to weight loss and fatigue. An uncontrolled diabetes was found and the computer tomography scan of the abdomen revealed a tumor located in the tail of the pancreas with liver metastases. Subsequently, liver biopsy and high levels of glucagon confirmed the diagnosis of glucagonoma. The patient was treated with short-acting subcutaneous octreotide for 2 weeks and then with intramuscular slow-release octreotide every 28 days, with a significant improvement of the symptoms.

Conclusion:
This case provides further knowledge about NME, since a timely recognition and treatment of this misleading disease can prevent morbidity from the dermatitis and mortality from the malignancy itself.
Prenatal diagnosis of fetal craniofacial teratoma: US, MRI findings, a rare case report
Authors: Toprak Nurşen , Gunduz Ali Mahir , Aras Ibrahim , Ilık Ibrahim , Kucukbas Gokcenaz , Goya Cemil , Sahın Hanım 
Published: March 2021

Background:
Craniofacial teratoma is a rare congenital malformation. We present a case of an intracranial expanding orofacial teratoma, where pathological examination revealed the findings of remarkable ultrasonographic signs and magnetic resonance imaging (MRI).

Case Presentation:
In the 23-week ultrasound examination, a solid cystic mass lesion was revealed in the craniofacial region. MRI showed that the mass had an intracranial extension and spread to the fetal face, and also revealed a marked nasopharyngeal obstruction by the mass. There was a growing tumor protruding from the fetus’s mouth. Slight polyhydramnios was also detected.

Conclusion:
In detecting prenatal anomaly, although the ultrasound is the first scan method applied, MRI in prenatal diagnosis is very useful for evaluating the extent, nasopharyngeal obstruction degree, and extension into the intracranial region of craniofacial teratoma.
Case of the week: Updating a cervical MR scan avoided unnecessary cervical surgery
Authors: Epstein Nancy E. 
Published: March 2021

Background:
As spinal surgeons, we have all likely seen cases in which lumbar disc herniations regressed/resolved on successive MR studies. Here, we present a patient whose original cervical MR showed a large C4-C5 cervical disc herniation that completely resolved on the follow-up MR obtained 9 months later, thus avoiding cervical surgery.

Case Description:
A young patient (e.g. <30 years old) sustained multiple prior traumatic events over the past 3 years. The last episode 9 months ago resulted in the performance of an MR scan that demonstrated a significant central C4-C5 disc herniation with cord/root compression. Despite pain and mild radiculopathy, the patient had no focal neurological deficit, and did not undergo surgery. When the patient recently consulted multiple spinal orthopedists and neurosurgeons, the uniform recommendation was for a C4-C5 anterior cervical discectomy/ fusion (ACDF). However, a telemedicine consultation with a spinal neurosurgeon resulted in a follow-up cervical MR scan that demonstrated cervical disc resorption, and, therefore, no need for cervical surgical intervention. When the new study showed full resolution of the C4-C5 disc, the telemedicine and local neurosurgeon agreed that cervical surgery was unnecessary.

Conclusion:
The spinal literature shows that predominantly lumbar disc herniations (LDH) spontaneously regress on MR studies 34.7–95% of the time over 6–17 month intervals, with full resolution being seen in 43–75% of cases. As cervical disc herniations likely demonstrate similar resorption/resolution on successive MR studies, old cervical MR examinations should probably be updated/repeated in patients who are being considered for cervical surgical intervention. If/when cervical discs have resorbed, cervical surgery may be avoided.
International travel and acquisition of multidrug-resistant Enterobacteriaceae: a systematic review
Authors: Hassing Robert Jan , Alsma Jelmer , Arcilla Maris S. , van Genderen Perry J. , Stricker Bruno H. , Verbon Annelies 
Published: March 2021

International travel is considered to be an important risk factor for acquisition of multidrug-resistant Enterobacteriaceae (MRE). The aim of this systematic review was to determine the effect of international travel on the risk of post-travel faecal carriage of MRE. Secondary outcomes were risk factors for acquisition of MRE. A systematic search for relevant literature in seven international databases was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Articles needed to report on (i) foreign travel, (ii) screening of asymptomatic participants, (iii) antimicrobial susceptibility data and (iv) faecal Enterobacteriaceae carriage. Two researchers independently screened the abstracts, assessed the full article texts for eligibility and selected or rejected them for inclusion in the systematic review. In case of disagreement, a third researcher decided on inclusion. Eleven studies were identified. In all studies, a high prevalence (> 20%) of carriage of MRE after international travel was found. The highest prevalence was observed in travellers returning from southern Asia. Foreign travel was associated with an increased risk of carriage of MRE. Further research is needed to assess if this leads to an increase in the number of infections with MRE. Systematic review registration number: PROSPERO CRD42015024973.