bluuebunny/crossref_metadata_2025_split huggingface dataset:
The drivers of vine-plant root microbiota endosphere composition include both abiotic and plant-specific factors
Authors: Biget Marine , Mony Cendrine , Aubry Marc , Jambon Olivier , Quaiser Achim , Chable Véronique , Pernet Sabrina , Vandenkoornhuyse Philippe 
Published: September 2021

Microorganisms associated with plants are determinant for their fitness, but also in the case of vine grapes, for the quality and quantity of the wine. Plant microbiota is, however highly variable in space despite deterministic recruitment from the soil reservoir. Therefore, understanding the drivers that shape this microbiota is a key issue. Most studies that have analysed microorganisms associated with vines have been conducted at large scales (e.g., over 100 km) and have analysed the bulk soil and the rhizosphere. In this study, we focused on the root-microbiota endosphere, the most intimate fraction of microorganisms associated with plants. We sampled vine roots in 37 fields distributed throughout a vineyard to investigate drivers shaping the grapevine microbiota at the α- (i.e., within-field) and γ- (i.e., between-field) diversity scales. We demonstrated that vine endospheric microbiota differed according to both the edaphic and plant-specific parameters including cultivar type and age. This work supports the idea of an existing microbial terroir occurring within a domain and offers a new perspective for winemakers to include the microbial terroir in their management practices.
Business Cluster and Entrepreneurship Growth in Nigeria: A Systematic Review.
Authors: Mustapha Isiaka , Umaru Mustapha Zubairu , Busra Sakariyau 
Published: September 2021

The research in business clusters (BC) system of entrepreneurship development has increased in the recent year. A plethora of research has explored; entrepreneurship and urban growth, the entrepreneurial attitudes on the structure of support for entrepreneurship in an ecosystem, the effect of business clusters on firm performance and more recently, the dimension of agglomeration, institution and environment on business clusters. With the aid of Systematic Qualitative Assessment Techniques (SQAT), we review 79 business cluster journal articles published over the last 11 years (2010 – 2020) that sought to provide BC antecedent and impact on entrepreneurship and economy growth to provide a point for future research. Also, the review provides the geographic distribution, time distribution, underlying drivers of previous research, types and method of data collection used by these BC articles. Our findings shed light on the key themes including the evolution of BC, the impact of BC on the economy, application of BCs and the public policy maker roles. Furthermore, there is a dearth of BC research in Africa, South America and Australasia with most BC research are empirical and this represents gaps for future researchers to explore.
Very Low and High Blood Viscosity are Risk Factors for Internal Flow Choking Causing Asymptomatic Cardiovascular Disease
Authors: Kumar V. R. Sanal , Choudhary Shiv Kumar , Radhakrishnan Pradeep Kumar , Bharath R. S. , Chandrasekaran Nichith , Sankar Vigneshwaran , Sukumaran Ajith , Oommen Charlie 
Published: September 2021

Abstract
Herein, we established the proof of the concept of internal flow choking in CVS causing cardiovascular risk through the closed-form analytical, in vitro and in silico methods. An over dose of blood-thinning drug will enhance the Reynolds number, which creates high turbulence level causing an augmented boundary layer blockage factor leading to an early undesirable biofluid/Sanal flow choking at a critical blood-pressure-ratio (BPR). The fact is that in nanoscale vessels when the pressure of fluid increases, average-mean-free-path decreases and thus, the Knudsen number reduces. It leads to the physical situation of no-slip boundary condition with compressible-viscous flow effect. Sanal-flow-choking is a compressible-viscous flow effect establishing a physical condition of the sonic-fluid-throat, at a critical blood pressure ratio (BPR). We concluded that asymptomatic-hemorrhage (AH) and acute-heart-failure (AHF) are transient-events as a result of internal flow-choking in nanoscale and/or large vessels followed by the shock wave creation and transient pressure-overshoot. We concluded that cardiovascular risk could be reduced by simultaneously lessening the blood-viscosity and flow turbulence by increasing thermal-tolerance-level in terms of BHCR and/or by decreasing the blood pressure (BP) ratio.
The Deceleration of Radio/Light Transmission; A Collision Mechanism Dependent Radio Signal Emission, Transmission, and Reception
Authors: Zhang Jing 
Published: September 2021

Abstract
The fast and slow fading of radio signal transmissions or laser beam itself and its spare light confirm the presence of two kinds of collisions --- electron-photon and photon-photon collision. Photon transmissions of radio signals are either consecutive dense photon groups in slow fading process or widespread group pattern in fast fading form. The photon transmission shapes are irregular and dynamical changes. The radio frequency shift and the wavelength reduction by the calculation demonstrate decelerations of radio/light transmission speeds due to the gradual reduced distance between two consecutive photon groups along the transmission pathway. Photons from radio signals are able to affect electron movements in radio signal receiving process and electrons able to kick photons into space during radio signal emission. The pattern of free electron movement under the influence of local electromagnetic force in antenna is consistent with the randomly dynamic changes of radio signal in space. The fast fading is due to the collision of consecutive photon groups of signals in slow fading with free photons in space. The shape changes of radio signal peaks suggest photons able to remain in transmission photon groups after photon-photon collision, leading to deceleration transmissions in slow fading. The mathematical equation for the relationship between light/radio transmission speeds before and after photons collisions is established. The equation is confirmed by the calculations of well-known difference of light transmission speeds in different media. The gravities from Earth and Sun play little role during light/radio transmission.
Predicting Mechanical Ventilation For More Than 7 Days In The Emergency Department
Authors: Paik Jin Hui , Kim Jung-Soo , Lee Man-Jong , Park Mi Hwa , Durey Areum , Kim Ah Jin 
Published: September 2021

Abstract
Background: The duration of mechanical ventilation (MV) required by patients admitted to the emergency department (ED) is difficult to predict. We investigated the duration of MV in ED-admitted patients, as well as their clinical progress.Methods: We investigated the duration of MV in adult patients (aged ≥18 years) who were attached to ventilators in our ED between January and December 2017. The patients were divided into two groups; MV <7 days and MV ≥7 days. The patients’ demographic characteristics, diagnoses, clinical features, and underlying diseases were compared between two groups.Results: The study comprised 282 patients including 142 in the MV <7 days group and 140 in the MV ≥7 days group. The MV ≥7 days group had more patients diagnosed with metabolic disorder, pneumonia, neurological disease, sepsis, and multiple trauma, and also had a greater proportion of patients with dementia or stroke as the underlying disease. The mean C-reactive protein level in the MV ≥7 days group was 6.4 mg/dL, which was higher than that in the MV <7 days group. The risk factors for requiring ≥7 days of MV were identified as a diagnosis of stroke as well as having the underlying diseases of cancer and stroke or dementia. Among the laboratory test results, pH, HCO3- , and albumin <3.5 g/dL were identified as factors influencing the duration of MV.Conclusions: MV for ≥7 days is predicted to be required for patients admitted for a stroke; those with underlying cancer or stroke; and those with adverse pH, HCO3-, and albumin blood test results.
Challenges of Emergency Medical Services utilization by the older adults in Tabriz, Iran
Authors: Ghafouri Rouzbeh Rajaei , Sahebihagh Mohammad Hasan , Mohammadpoorasl Asghar , Parsian Zahra , Yousefi Mahmood , Azizi-Zeinalhajlou Akbar 
Published: September 2021

Abstract
Background

As the number of older adults is increasing, the health care services such as Emergency Medical Services (EMS) should be promoted. One of the preconditions for the use of health services is awareness of these services and their terms of use. This study is conducted to evaluate the awareness of the older adults in Tabriz about EMS and the terms of services.
Methods

This cross-sectional survey was conducted in a representative sample of over 60 years old noninstitutionalized population in Tabriz (Iran). It included 1062 participants (514 males and 548 females) who were selected using Probability Proportional to Size (PPS) sampling method. Service awareness is considered as being informed about the existence of the EMS. Knowledge about EMS is defined as knowing the EMS phone number and knowledge about its free and 24-hour service. After completing the informed consent, data collection was conducted in the households of the participants. Data analysis was conducted using logistic regression.
Results

The findings showed that 47% of the older adults were not familiar with the EMS system. Awareness of EMS in males (63.4%) was higher than females (44.2%) and also it was higher among those born in cities (61.2%) than rural areas (46.1%). Holding primary, secondary, and higher education compared with illiteracy had higher chance of awareness of EMS by more than 2, 4, and 12 times respectively (OR = 2.53, OR = 4.69, and OR = 12.09).
Conclusion

Due to high rate of illiteracy and low public awareness, older adults do not have appropriate knowledge about the facilities, conditions, and terms of using EMS and may not be able to demand some of their essential services; therefore, notifying and increasing awareness about the available services to older adults are necessary.
Rule Reductions of Decision Formal Context Based on Mixed Information
Authors: Lin Yidong , Li Jinjin , Huang Ju 
Published: September 2021

Abstract
Three-way concept lattice extracts knowledge from positive and negative information separately. However, some applications require to mix positive and negative information for management and representation explicitly. In this paper, rule acquisition of FCA is extended based on mixed information. Firstly, two types of mixed concept lattices are studied. Then the relationships between mixed concept and classical concept, three-way concept are explored in depth. Secondly, mixed decision rules are investigated thoroughly. And the weak-basis is put forward to approximate to the basis of mixed decision rules. Finally, the comparison of mixed decision rules and three-way decision rules is perfectly discussed.
Lipid Mediator n-3 Docosapentaenoic Acid-Derived Protectin D1­(PD1n-3DPA) Enhances Synaptic Inhibition of Hippocampal Principal Neurons by Interaction with a G-Protein Coupled Receptor
Authors: Mikroulis Apostolos , Ledri Marco , Ruffolo Gabriele , Palma Eleonora , Sperk Günther , Dalli Jesmond , Vezzani Annamaria , Kokaia Merab 
Published: September 2021

Abstract
Epilepsy is a severe neurological disease manifested by spontaneous recurrent seizures due to abnormal hyper-synchronisation of neuronal activity. Epilepsy affects about 1% of the population and up to 40% of patients experience seizures that are resistant to currently available drugs, thus highlighting an urgent need for novel treatments. In this regard, anti-inflammatory drugs emerged as potential therapeutic candidates. In particular, specific molecules apt to resolve the neuroinflammatory response occurring in acquired epilepsies have been proven to counteract seizures in experimental models, and in humans. One candidate investigational molecule has been recently identified as the lipid mediator n-3 docosapentaenoic acid-derived protectin D1(PD1 n-3DPA ) which significantly reduced seizures, cell loss and cognitive deficit in a mouse model of acquired epilepsy. However, the mechanisms that mediate PD1 n-3DPA effect remain elusive. We here addressed whether PD1 n-3DPA has direct effects on neuronal activity independent on its anti-inflammatory action. We incubated therefore hippocampal slices with PD1 n-3DPA and investigated its effect on excitatory and inhibitory synaptic inputs to the CA1 pyramidal neurons. We demonstrate that inhibitory drive onto the perisomatic region of the pyramidal neurons is increased by PD1 n-3DPA , and this effect is mediated by pertussis toxin-sensitive G-protein coupled receptors. Our data indicate that PD1 n-3DPA acts directly on inhibitory transmission, most likely at presynaptic site of inhibitory synapses as also supported by oocyte and immunohistochemical experiments. Thus, in addition to its anti-inflammatory effects, PD1 n-3DPA anti-seizure and neuroprotective effects may be mediated by its direct action on neuronal excitability by modulating their synaptic inputs.
Pre-Treatment with Quercetin Prevents Dementia in Streptozotocin Treated Zebrafish via Modulation of Neuroinflammation and Oxidative Stress
Authors: Pradhan Nilima , Devi Bhawna , Sharma Deepali , Singh Charan , Singh Arti 
Published: September 2021

Abstract
Aim: To examine the protective outcome of quercetin against streptozotocin induced dementia in adult zebrafish. Materials and method: In this study, adult zebrafish (weighing 470-530 mg) were subjected to the streptozotocin administration (300 mg/kg; i.p) followed by a quercetin (50 & 100mg/kg i.p) pre-treatment before 24 hr of streptozotocin administration followed by blood glucose level measurement, behavioral parameters (light-dark test, novel diving test, open field test and T-maze test), biochemical parameters (lipid peroxidase, reduced glutathione, nitrite and AChEs activity), molecular and histopathological analysis. Results: In light-dark test, streptozotocin treated zebrafish shown their preference in dark compartment as compared to normal group. In novel diving tank, streptozotocin zebrafish spent less time and decrease in total number of entries to the top zone when compared to the normal group. In the T-maze test, streptozotocin treated zebrafish has shown significantly more time spent in unfavorable zone and less time spent in favorable zone with increase in total latency as compared to normal group. However, in the open field test no significant effect was seen among any group. Moreover, pre-treatment with quercetin (50 mg/kg and 100 mg/kg) significantly ameliorated the memory deficits in all the behavioral, biochemical and molecular parameters as compared to animals treated with streptozotocin. Additionally, results of histopathology studies showed less disruption in neuronal cells in quercetin treated group when compared to STZ treated animals.Conclusion: Pre-treatment with quercetin ameliorates streptozotocin induced dementia in adult zebrafish by preventing oxidative stress and neuroinflammation.
Elagolix Treatment in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroid: A Systematic Review and Meta-analysis
Authors: Yusof Yusnita , Norhayati Mohd Noor , Muhammad Juliawati , Ahmad Imran 
Published: September 2021

Abstract
Background: Elagolix is effective and safe for treating menorrhagia in women with uterine fibroid. However, it is reported to be associated with hypoestrogenism that can be alleviated by adding estradiol/norethindrone acetate. This systematic review and meta-analysis aimed to determine the effectiveness of elagolix treatment in women with heavy menstrual bleeding associated with uterine fibroid by comparing: elagolix versus placebo and elagolix versus estradiol/norethindrone acetate.Methodology: The Cochrane Central Register of Controlled Trials (CENTRAL 2021, Issue 3 of 12), MEDLINE databases (1980 to December week 1, 2020), and trial registries for relevant randomized clinical trials were used. All randomized clinical trials were reviewed and evaluated. Random effects models were used to estimate the dichotomous outcomes and mean differences with 95% confidence intervals. Data for risk of bias, heterogeneity, sensitivity, reporting bias and quality of evidence were assessed. Results: Four randomized controlled trials with 1949 premenopausal women from 323 locations were included. Elagolix improved menstrual blood loss of less than 80 ml (RR 4.81, 95% CI 2.45 to 9.45; four trials, 869 participants; moderate quality evidence) or more than 50% reduction from baseline (RR 4.87, 95% CI 2.55 to 9.31; four trials, 869 participants; moderate quality evidence) compared to placebo. There was no difference in menstrual blood loss of less than 80 ml (RR 1.08, 95% CI 1.00 to 1.16; five trials, 1365 participants; moderate quality evidence) or more than 50% reduction from baseline between the elagolix (RR 1.08, 95% CI 1.01 to 1.15; five trials, 1365 participants; high quality evidence) and elagolix with estradiol/norethindrone acetate. In both comparisons, elagolix has reduced the mean percentage change in uterine and fibroid volume, improved symptoms, and health-related quality of life. More patients had hot flush, and bone mineral density loss in the elagolix treatment compared to both placebo and elagolix with estradiol/norethindrone acetate.Conclusions: Elagolix appeared to be effective in reducing heavy menstrual bleeding caused by uterine fibroid and combination with estradiol/norethindrone acetate was able to alleviate the hypoestrogenism side effects in premenopausal women.Review registration. PROSPERO CDR 42021233898.
Haematological, Oxidative Stress and Trace Elements Variations Associated with Emaciation in Pre-Slaughter White Fulani Cows
Authors: Thomas Funmilola Clara , Antia Richard Edem , Mshelbwala Fakilahyel , Ajibola Eyitayo Solomon , Ohore Obokparo Godspower , Rahman Samson Adisa , Ayanleye Abdulhafiz Oloruntoba 
Published: September 2021

Abstract
Pre-slaughter White Fulani cows were purposively sampled on the basis of body condition: emaciated (n=37) and non-emaciated (n=37), with the objective of understanding the intricate interplay of oxidative stress, trace elements and haematological variations during emaciation. Blood was drawn from the jugular vein for haematological analysis and accruing serum was used for the evaluation of malondialdehyde (oxidative stress marker), antioxidant enzymes and compounds, serum protein, electrolytes as well as trace elements. Significant (p < 0.05) differences between the emaciated and non-emaciated cows were established only in the values of copper and reduced glutathione (GSH), which were lower in emaciated cows (EC). None of the animals had packed cell volume (PCV) below the normal reference range, however values above the normal (> 46%) were seen, suggesting dehydration. The PCV in emaciated cattle was slightly lower than in non-emaciated cows. The mean malondialdehyde concentration in non-emaciated cattle was higher than that in emaciated ones, however antioxidants SOD, catalase, Vitamin C and zinc were slightly higher in non-emaciated cows (NEC). Overall, the results indicate that emaciation in studied White Fulani cows (WFC) displayed a variable redox homeostasis confounded by dehydration and depletion of antioxidants.
Cancer-Related Cognitive Impairment: A Mixed-Methods Evaluation of A Standard Factsheet
Authors: Lim Chloe Yi Shing , He Sharon , Shaw Joanne , Dhillon Haryana M 
Published: September 2021

Abstract
Purpose: To understand the impact of cancer survivors accessing a standard factsheet regarding cancer-related cognitive impairment (CRCI), publicly available to the Australian public via Cancer Council Australia’s websites. Methods: Twenty-three cancer survivors completed a questionnaire assessing pre-factsheet knowledge of CRCI. Semi-structured interviews were conducted to explore participants’ experiences of CRCI and perceptions of the factsheet. Interviews were analysed via thematic analysis using a framework approach. Finally, participants completed another questionnaire assessing post-factsheet change in knowledge of CRCI.Results: Pre- and post-factsheet questionnaire change scores indicated increased knowledge and greater confidence about CRCI. Interview data resulted in five themes: generally positive perceptions of the factsheet’s layout and wording; survivors, regardless of treatments received, experienced CRCI symptoms, with some having strong negative emotional responses to their symptoms; perceptions of the factsheet’s strategies to manage CRCI ranged from relevant and useful, to impractical or unrealistic if symptoms were too severe; interactions with healthcare system influenced survivors’ perceptions of help-seeking, with negative healthcare experiences a major barrier; and, generally positive impacts of the factsheet, with survivors praising the factsheet’s ability to validate the CRCI experience, increase CRCI knowledge, influence health beliefs, and prompt help-seeking.Conclusion: The factsheet presentation and wording were acceptable to participants. Its ability to normalise and raise awareness for CRCI validated participants’ symptoms. The factsheet’s potential as a first-line intervention in a stepped-care approach was identified, with participants finding the suggested self-management strategies practical. The factsheet may overcome barriers to self-reporting by encouraging patients to talk with HCPs about CRCI.
Transgenerational Effects of Environmentally Relevant Concentrations of Atrazine and Glyphosate Herbicides, Isolated and in Mixture, to Freshwater Microcrustacean Daphnia Magna
Authors: Ramsdorf Wanessa A , Bordin Eduarda Roberta , Munhoz Renan cesar , Panicio Paloma Pucholobek , Freitas Adriane Martins 
Published: September 2021

Abstract
Herbicide mixture is used as an alternative to obtain different mechanisms of action acting on weeds, resulting in the frequent presence of pesticides in environmental compartments. As they are products used worldwide, this study evaluated effects of environmentally relevant concentrations of the analytical standards and commercial formulations of the herbicides atrazine (2 µg L− 1) and glyphosate (65 µg L− 1), in isolation and also in mixture (2 + 65 µg L− 1) on the microcrustacean Daphnia magna. Through chronic exposure (21 days) of two generations of organisms, effects on survival and reproductive capacity were observed, as well as responses regarding oxidative stress, determined through the analysis of biochemical biomarkers such as catalase and glutathione S-transferase. In the evaluation of the first generation of test organisms, no significant results related to biochemical biomarkers were observed, only effects over sexual maturation of organisms. However, in the second generation of exposed organisms, changes were observed in all parameters evaluated, with the mixture of herbicide active principles being the treatment responsible for more significant responses (p < 0.05). A statistical difference (p < 0.05) was also observed between analytical standards and commercial formulations, indicating that other components present in the formulations can change the toxicity of the products. Given the difficulty of estimating the effects of mixtures and considering that various stressors are found in the environment, our results support the need to carry out studies that address long-term effects and, above all, that verify what the impacts are across generations, so that the toxicity of products is not underestimated.