bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Non-Energy Devices and Nerve Monitoring in Preventing Recurrent Laryngeal Nerve Injury in Lung Cancer Surgery
Authors: Liu Caiyang , He Xing , Lei Yu , Shao Hong , Li Xiaoliang , Wang Yi , Li Ji , Ran Ran 
Published: December 2024

Abstract

Systematic nodal dissection is crucial for lung cancer patients undergoing complete resection, but it carries a risk of recurrent laryngeal nerve (RLN) injury (RLNI). To protect the RLN, we utilized a combination of non-energy devices and RLN monitoring (NE-RLNM). Lung cancer patients who underwent uniportal video-assisted thoracoscopic surgery were included in the study and divided into two groups: an energy group and a NE-RLNM group. Propensity score matching was applied to balance baseline clinical data, and both intraoperative and postoperative conditions were analyzed retrospectively. Univariate and multivariate analyses were conducted to identify risk factors of RLNI. Among the 409 patients included, there were 187 in the energy group and 222 in the NE-RLNM group. After 1:1 propensity score matching, 166 pairs of patients were matched. The energy group reported shorter operative time (P<0.001) and less day 1 chest tube drainage (P=0.001)than the NE-RLNM group. However, the NE-RLNM group had a lower RLNI rate (P=0.011) and a higher recovery rate (P=0.034) than the energy group. Side of the primary tumor (OR=2.88, 95% CI: 1.20-6.88, P=0.017), pTNM stage (OR=5.62, 95% CI: 1.57-20.13, P=0.008), and surgical devices (OR=0.40, 95% CI: 0.18-0.91, P=0.029) were independent predictors of RLNI. The use of NE-RLNM appears effective in reducing RLNI incidence and improving recovery rates. Our study provides new insights into RLN preservation during complete lung cancer resection.
The Epidemic of Childhood Obesity and the COVID-19 Pandemic: Metabolic Characteristics and Effects of Therapy
Authors: Fabin-Czepiel Kalina , Zachurzok Agnieszka , Pieczyńska-Chapuła Karolina , Pyziak-Skupień Aleksandra , Matusik Paweł , Jarosz-Chobot Przemysława , Deja Grażyna 
Published: December 2024

Abstract

The aim of the study was to analyse whether children whose obesity occurred during the pandemic differed metabolically from children who were obese earlier and to assess the effect of one-year treatment following the end of pandemic restrictions. The prospective study of 55 children aged 10–18 years who were referred to the Outpatient’s Clinic during the pandemic due to obesity was conducted. Clinical data were analysed: time of obesity onset, BMI Z-score, body mass composition, blood pressure, abdominal ultrasound, biochemical parameters of lipid and carbohydrate metabolism, aminotransferases and Fetuin A concentration. Participants received recommendations to improve their diet and increase physical activity (PA). After 3, 6 and 12 months we assessed: BMI Z-score, compliance with recommendations, and biochemical parameters. Results: No significant differences between pandemic obesity and non-pandemic obesity were observed at the beginning and after one year. Both children who followed the dietary recommendations had significantly lower BMI Z-score after 3 months (Me 2.08 vs 1.89, p = 0.044) and children who declared increasing PA (47.3%) after 6 (Me 2.12 vs 1.86, p = 0.53) and 12 months (Me 2.12 vs 1.78, p = 0,008). The beneficial effect of PA was demonstrated in lower levels of Fetuin A in children with increased PA after 6 months (Me 480 vs 395 ug/ml, p = 0.07). Conclusions The “pandemic obesity” does not appear to be metabolically distinct from obesity that developed earlier and lasted longer.. Increase in PA and compliance with dietary recommendations seems still to be an important element in therapy and the context of metabolic complications. Fetuin A may serve as a potential new parameter for assessing compliance with PA recommendations and the rate of obesity progression.
Association of weight-adjusted waist index with all-cause and cardiovascular mortality in individuals with osteoarthritis
Authors: Guo Shaoyi , Chen Dan , Zhang Yunfeng , Cao Kaiqi , Xia Yongqi , Yang Dejin 
Published: December 2024

Abstract

Background
The Weight-Adjusted waist index (WWI) is a novel obesity assessment parameter that has been shown to be associated with mortality in various chronic disease populations and is also linked to the onset of osteoarthritis (OA). The aim of this study is to investigate whether WWI is associated with all-cause and cardiovascular mortality in OA population.
Methods
The study analyzed a cohort of 3,554 OA patients drawn from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2018. Kaplan-Meier survival curves, Cox proportional hazards regression models, and subgroup analyses were utilized to assess the association between WWI and mortality outcomes. The dose-response relationship was examined using a restricted cubic spline (RCS) model.
Results
Among the 3,554 OA individuals, 611 participants were determined as deceased (13%), and 26% of the deaths were due to cardiovascular causes. The fully adjusted Cox proportional hazards model revealed that elevated WWI values were significantly associated with a higher risk of all-cause mortality (HR = 1.28, 95% CI 1.07‒1.52). The association between WWI and cardiovascular mortality in OA patients was only observed in the minimally adjusted model (HR = 1.43, 95% CI 1.12‒1.81). A similar conclusion was observed when the participants were grouped according to WWI tertiles. Kaplan-Meier survival curves demonstrated elevated mortality rates among individuals with higher WWI. The dose-response analysis indicated a linear positive relationship between WWI and mortality rates. The above associations remained consistent across all subgroups.
Conclusion
Elevated WWI levels were associated with a higher risk of all-cause mortality in OA individuals independently.
Social-ecological model determinants of anaemia severity levels among children under five in Ashanti Region: A multinomial logistic regression based on the 2022 Ghana Demographic and Health Survey
Authors: Sackey Jonathan , Lokko Christiana Naa Momo , Baah Emmanuel Mensah 
Published: December 2024

Abstract

Anaemia is a significant global health issue, particularly affecting children under five years and women of reproductive age, with children being disproportionately impacted due to rapid growth and increased iron demand. It is an indicator of poor nutrition and health and a major barrier to social and economic development. For children under five, anaemia is a haemoglobin concentration below 110 g/l. This study aimed to examine the severity of anaemia among children under five in Ghana and identify predictors based on the socio-ecological model. Using data from the 2022 Ghana Demographic and Health Survey (GDHS) and a sample of 662 children, multinomial logistic regression was applied for the analysis. The findings revealed that 32.4% of children experienced some form of anaemia, with 11.9% having moderate to severe anaemia. Individual (currently breastfeeding, had diarrhoea recently maternal age, maternal education, wealth index and ethnicity) and institutional (proximity to health facility) factors predicted anaemia severity. This study underscores the need for targeted interventions focused on individual factors, healthcare access, and breastfeeding support to reduce anaemia prevalence among children in Ghana.
'Flexibility is the name of the game’: Clinicians’ Views of Optimal Dose of Psychological Interventions for Psychosis and Paranoia
Authors: Fialho Carolina , Abouzahr Alya , Jacobsen Pamela , Shergill Sukhi , Stahl Daniel , Yiend Jenny 
Published: December 2024

Abstract

In the UK, NICE (2014) recommends a minimum of 16 sessions of Cognitive Behaviour Therapy for the treatment of psychosis. One of the barriers to implementation is that clinicians’ views of optimum doses may not fit with this guidance. This study investigates the views of clinicians on the optimal dose of interventions. Fifteen clinicians participated in four focus groups and completed a bespoke questionnaire investigating experiences of dose in different contexts. We used the framework method for data analysis, with Voils et al. (2012) conceptualization of dose as the frame.
We identified three deductive themes on dose components; number, frequency, and length of therapy sessions. In community settings, participants recommended 1-5 sessions for shorter-term goals, 10-12 sessions for longer-term goals, and highlighted the importance of review after 20-26 sessions. While a range of 16-26 sessions was identified as optimal, a consensus formed around dose being variable to each individual. In inpatient settings, number of sessions was largely dependent on length of stay. In community settings participants found it helpful to initially have weekly sessions and then transition to fortnightly, while in inpatient settings participants met with patients 1-3 times a week. In community settings, participants reported often delivering 50–60 minute sessions (although that could vary); while in inpatient settings sessions lasted from 5 min to 2 hours. Dose recommendations for community settings applied to digital therapies.
We constructed four inductive themes on how clinicians adapt dose in clinical practice; (1) context matters, (2) individualised treatment approaches, (3) flexibility is key, and (4) balancing clinical idealism and service constraints. Complementing the NICE guidance, our findings endorsed the use of a variable index of sessions to address variability in clinical need. The incorporation of stakeholder views is essential to contextualise quantitative evidence-based recommendations.
Quality of Life Post Heart Failure Diagnosis: Population-Level Trends in the U.S
Authors: Alva Maria , Dolman Sarahfaye , Sikirica Slaven , Kolm Paul , Andrade Katherine , Zhang Zugui , Weintraub William 
Published: December 2024

Abstract

Background. Individuals with heart failure (HF) experience various symptoms making both diagnosis and disease burden estimates challenging. While HF-specific patient-reported outcome measures (PROMs) are widely used, their focus on clinical cohorts limits their generalizability. Preference-based measures like the EQ-5D enable standardized health-related quality of life (QoL) comparisons across conditions, supporting resource allocation decisions. The CDC’s Healthy Days (HD) Survey—a simple two-question tool that can be mapped to the EQ-5D—offers a broader approach to tracking QoL but remains underutilized in HF populations. Methods. Using a nationally representative U.S. sample, we mapped HD Survey responses to EQ-5D utility scores to compare QoL between individuals with and without HF and examined changes in QoL over time. We assessed whether HD-derived scores align with HF-specific utility measures to support population-level health monitoring. Results. Individuals with HF report significantly more physically unhealthy days (8.46 vs. 3.42) and mentally unhealthy days (5.42 vs. 3.86) compared to those without HF. HF respondents are, on average, 20 years older than those without HF, consistent with HF's prevalence in older adults. The likelihood of an HF diagnosis is similar for men and women but higher among non-Hispanic whites and blacks than Hispanics and other races. Those with HF are more likely to have health insurance. Adjusting for age, sex, race, and insurance, mean EQ-5D utility scores for individuals with and without HF are 0.785 (95% CI: 0.714–0.825) and 0.840 (95% CI: 0.827–0.851), respectively. Utility scores for HF patients remain significantly lower than those without HF up to 10 years post-diagnosis. Conclusion. HF reduces QoL by 6.55%, surpassing the clinically significant threshold of a 1–2% decrement. These findings highlight the potential of the HD Survey to inform public health monitoring and underscore the need for tailored interventions to address QoL deficits in HF populations.
Hederagenin attenuates renal senescence in diabetic kidney disease by inhibiting DNMT1- mediated Klotho DNA methylation
Authors: Luo Guanfeng , Liu Minyu , Yu Wenbin , Liu Huaxi , Zhou Jie , Li Dexian , Chen Fangxin , Kwan Hiu Yee , Tang Yang , You Yanting , Zhao Xiaoshan , Sun Xiaomin 
Published: December 2024

Abstract

Renal senescence plays a crucial role in the development of diabetic kidney disease (DKD). The progression of DKD can accelerate the senescence process of the kidney, making it more susceptible to diabetes-induced damage and accelerating the process of renal fibrosis. However, there is no effective treatment for this pathological process. Hederagenin (Hed) has shown promising improvements in renal fibrosis in chronic kidney disease and DKD, but its mechanism in DKD-induced renal senescence remains unclear. In this study, we found that Hed exhibited significant anti-renal senescence effects in palmitic acid-induced HK-2 cell senescence and in the kidneys of db/db mice. Additionally, through the GEO database, we discovered that Klotho is significantly downregulated in patients with DKD, and Hed can restore the expression of Klotho in senescence HK-2 cells and the kidneys of db/db mice. We utilized molecular docking, molecular dynamics simulation and surface plasmon resonance to find that Hed can bind to DNMT1. CHIP-qPCR experiments revealed that Hed competitively inhibits the binding of DNMT1 to the Klotho promoter region. Collectively, our study demonstrates that Hed possesses anti-renal senescence effects by interfering with the DNMT1-mediated Klotho DNA methylation process, thereby restoring Klotho expression and reducing DNA damage. These findings provide new mechanistic insights into the therapeutic potential of Hed in the treatment of DKD.
Virological Outcomes and Dolutegravir Resistance Mutations in HIV-infected Patients: A Multicenter Retrospective Cohort Study in Mozambique
Authors: Altan Anna Maria Doro , Majid Noorjehan , Orlando Stefano , Uamusse Elton , Rafael Marcia , Sidumo Zita , Guidotti Giovanni , Ciccacci Fausto 
Published: December 2024

Abstract

Introduction The global HIV epidemic remains a public health challenge. Dolutegravir (DTG) has become a cornerstone of antiretroviral therapy (ART) regimens due to its efficacy and tolerability. However, the emergence of DTG resistance is a concern. This study aims to evaluate virological outcomes and the emergence of resistance mutations in patients treated with DTG in Mozambique.Methods A retrospective cohort study was conducted in seven DREAM centers in Mozambique. Data were collected from electronic medical records of patients on DTG-based ART between July-2022 and December-2023. Virological suppression rates, patient demographics and clinical characteristics, and the prevalence of resistance mutations were analyzed.Results A total of 29,601 patients were included, 98.1% (29,051 patients) were on DTG-based ART. The overall virological suppression rate among patients on DTG was 95% (27,622/29,051). Multivariate logistic regression analysis identified the following factors independently associated with virological suppression: older patients (aged > 50 years) had higher odds of achieving virological suppression (OR: 2.45, 95% CI: 1.85–3.26, p < 0.001), longer duration on ART (> 5 years) was also associated with suppression (OR: 1.92, 95% CI: 1.44–2.58, p < 0.001), female patients had higher odds of suppression (OR: 0.85, 95% CI: 0.75–0.97, p = 0.02), and patients treated in Quelimane City had lower odds of suppression compared to those in Machava (OR: 0.67, 95% CI: 0.52–0.86, p = 0.01). Of the 74 samples sent for resistance testing, 17 were analyzed for DTG resistance, and 8 displayed resistance major mutations. The most common mutations identified were G118R and E138K, variably associated with other major mutations.Conclusions This study demonstrates the effectiveness of DTG within the DREAM program in Mozambique, with a high rate of virological suppression. However, the emergence of resistance mutations underscores the need for ongoing monitoring and surveillance to optimize treatment outcomes and preserve the efficacy of DTG.
Rotating Flow of Two Immiscible Liquids in a Vertical Concentric Annulus
Authors: sabrina nouri 
Published: December 2024

Abstract

This paper conducts a numerical and analytical investigation into the impact of the rotation rate on the dynamics of two immiscible liquids flow between vertical concentric cylinders. The governing momentum and energy equations are solved using numerical method. The discretization of momentum and energy equations is realized employing the finite volume method. The correlation between velocity and pressure fields is established using the SIMPLER algorithm, ensuring interface continuity. The flow is induced by radial density gradients resulting from thermal boundary conditions. The inner cylinder is characterized by a dimensionless temperature of 0.5, while the outer cylinder is at -0.5. The adiabatic condition is maintained for horizontal boundaries. The vertical equation of motion incorporates the buoyancy term, assuming axisymmetric flow. The analytical solution considers the flow in one dimension focusing on azimuthal velocity profile. The study explores the impact of an analytical and numerical rotational Reynolds numbers on flow patterns and heat transfer. Both numerical and analytical findings converge effectively, particularly at low rotational rates. The observation that the rotation of the inner cylinder exerts centrifugal forces, impacting the flow of water and oil differentially, serves to validate the assumption of a planar interface.
PENGARUH KOMPETENSI, MOTIVASI DAN KOMPENSASI TERHADAP KINERJA KARYAWAN KONVEKSI FARZAN STORE COMAL KABUPATEN PEMALANG
Authors: Nursi Sa’id , Awali Husni 
Published: December 2024

Abstrak: Sumber daya manusia (SDM) merupakan suatu aset yang paling penting bagi perusahaan, dimana para karyawan itu pada hakekatnya berfungsi sebagai faktor penggerak jalannya atau kegiatan di suatu perusahaan. Suatu organisasi dapat melakukan aktivitasnya untuk mencapai tujuan yang diingikan perlu adanya manajemen yang baik terutama sumber daya manusia, karena sumber daya manusia merupakan modal utama dalam merencanakan, mengorganisir, mengarahkan serta menggerakkan sumber daya lainnya yang ada dalam suatu organisasi. Riset ini menggunakan penelitian lapangan (field research) dan menggunakan pendekatan kuantitatif. Objek penelitian ini adalah karyawan Konveksi Farzan Store Comal Kabupaten Pemalang. Teknik pengambilan sampel yang digunakan adalah purposive sampling Cara ini dipilih agar sampel yang diambil dapat mewakili sifat populasi tersebut. Kriteria sampel yang digunakan dalam penelitian ini yaitu karyawan Konveksi Farzan Store Comal Kabupaten Pemalang dan masa kerja karyawan minimal sudah berkerja selama 1 tahun. Hasil penelitian menunjukan Kompetensi berpengaruh positif dan signifikan terhadap Kinerja Karyawan di konveksi Farzan Store Comal Kabupaten Pemalang. Motivasi berpengaruh positif dan signifikan terhadap Kinerja Karyawan di Konveksi Farzan Store Comal Kabupaten Pemalang. Kompensasi berpengaruh positif dan signifikan terhadap Kinerja Karyawan di Konveksi Farzan Store Comal Kabupaten Pemalang.
Kata Kunci: kompetensi; motivasi; kompensasi; kinerja.

Abstract: Human resources (HR) are the most important asset for a company, where employees essentially function as a driving factor for the running or activities in a company. An organization can carry out its activities to achieve the desired goals, good management is needed, especially human resources, because human resources are the main capital in planning, organizing, directing and mobilizing other resources in an organization. This research uses field research and uses a quantitative approach. The object of this research is employees of Konveksi Farzan Store Comal, Pemalang Regency. The sampling technique used is purposive sampling. This method was chosen so that the samples taken can represent the nature of the population. The sample criteria used in this study were employees of Konveksi Farzan Store Comal, Pemalang Regency and the employee's work period had been working for at least 1 year. The results of the study showed that competence had a positive and significant effect on employee performance at the Konveksi Farzan Store Comal, Pemalang Regency. Motivation had a positive and significant effect on employee performance at the Konveksi Farzan Store Comal, Pemalang Regency. compensation has a positive and significant effect on employee performance at the Farzan Store Comal convection, Pemalang Regency.
Keywords: competence; motivation; compensation; performance.
PERILAKU PENGELOLAAN KEUANGAN SYARIAH PADA GENERASI MILENIAL DALAM MEMEDIASI LITERASI KEUANGAN SYARIAH DAN PERILAKU INVESTASI
Authors: Khusnia Nur , Yazid Muhammad 
Published: December 2024

Abstrak: Tujuan utama dari penelitian ini adalah untuk berkontribusi pada literatur dengan berfokus pada hubungan antara literasi keuangan syariah dan perilaku investasi sekaligus mengidentifikasi efek mediasi perilaku pengelolaan keuangan syariah di kalangan generasi milenial. Penelitian ini mengadopsi desain penelitian kuantitatif. Data penelitian ini diperoleh melalui penyebaran dan pengisian kuesioner oleh generasi milenial di Surabaya. Penyebaran kuesioner dilakukan dalam rentang waktu 3 bulan (September-Oktober 2023). Populasi dalam penelitian ini terdiri dari generasi milenial di Surabaya, dan teknik pengambilan sampel yang digunakan adalah purposive sampling. SmartPLS versi 4 digunakan sebagai alat analisis data. Hasil penelitian menunjukkan bahwa literasi keuangan syariah berpengaruh positif dan signifikan terhadap perilaku pengelolaan keuangan syariah, perilaku pengelolaan keuangan syariah berpengaruh positif dan signifikan terhadap perilaku investasi, perilaku pengelolaan keuangan syariah berpengaruh positif dan signifikan dalam memediasi hubungan tersebut. antara literasi keuangan syariah dengan perilaku investasi, dan literasi keuangan syariah tidak berpengaruh terhadap perilaku investasi.
Kata Kunci: literasi keuangan; perilaku manajemen; investasi; generasi milenial; efek mediasi.

Abstract: The main objective of this study is to contribute to the literature by focusing on the relationship between Islamic financial literacy and investment behavior while identifying the mediating effect of Islamic financial management behavior among millennials. This study adopts a quantitative research design. The data of this study was obtained through distributing and filling out questionnaires by millennials in Surabaya. The questionnaires were distributed within a span of 3 months (September-October 2023). The population in this study consisted of millennials in Surabaya, and the sampling technique used was purposive sampling. SmartPLS version 4 was used as a data analysis tool. The results showed that Islamic financial literacy has a positive and significant effect on Islamic financial management behavior, Islamic financial management behavior has a positive and significant effect on investment behavior, Islamic financial management behavior has a positive and significant effect in mediating the relationship between Islamic financial literacy and investment behavior, and Islamic financial literacy has no effect on investment behavior.
Keywords: financial literacy; management behavior; investment; millennial generation; mediation effect.