bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atrial Fibrillation Detection Using Feedforward Neural Network
Authors: Chen Yunfan , Zhang Chong , Liu Chengyu , Wang Yiming , Wan Xiangkui 
Published: September 2021

Abstract
Atrial fibrillation is one of the most common arrhythmias in clinics, which has a great impact on people's physical and mental health. Electrocardiogram (ECG) based arrhythmia detection is widely used in early atrial fibrillation detection. However, ECG needs to be manually checked in clinical practice, which is time-consuming and labor-consuming. It is necessary to develop an automatic atrial fibrillation detection system. Recent research has demonstrated that deep learning technology can help to improve the performance of the automatic classification model of ECG signals. To this end, this work proposes effective deep learning based technology to automatically detect atrial fibrillation. First, novel preprocessing algorithms of wavelet transform and sliding window filtering (SWF) are introduced to reduce the noise of the ECG signal and to filter high-frequency components in the ECG signal, respectively. Then, a robust R-wave detection algorithm is developed, which achieves 99.22% detection sensitivity, 98.55% positive recognition rate, and 2.25% deviance on the MIT-BIH arrhythmia database. In addition, we propose a feedforward neural network (FNN) to detect atrial fibrillation based on ECG records. Experiments verified by a 10-fold cross-validation strategy show that the proposed model achieves competitive detection performance and can be applied to wearable detection devices. The proposed atrial fibrillation detection model achieves an accuracy of 84.00%, the detection sensitivity of 84.26%, the specificity of 93.23%, and the area under the receiver working curve of 89.40% on the mixed dataset composed of Challenge2017 database and MIT-BIH arrhythmia database.
Study On Laying Performances, Blood Biochemical Indicators, Feather Condition And Antibody Titers of Layer Breeders Among Different Tiers In Mating Cages During The Peak Laying Period*
Authors: LI Yan , MA Rui-yu , WAN Yi , QI Renrong , LI Jun-ying , LIU Wei , CUI Hai-jun , ZHANG Xin , LIU Zhejie , ZHAN Kai 
Published: September 2021

Abstract
The present study was conducted to determine the effect of cage tier on laying performances, blood biochemical indicators, feather condition and antibody titers of layer breeders among different tiers in mating cages during the peak laying period. All birds (Hy-Line Brown parent stock breeders) at 27 weeks of age were housed in 4-tier mating cage. Laying performances, egg quality characteristics, blood biochemical indicators, antibody titers and feather condition were measured. The highest laying rate was recorded at 2nd tier, followed by 4th tier and 3rd tier, and the lowest at 1st tier. There were no significant differences among different tiers in terms of percentage of defective eggs and hatchability performances. Yolk color was significantly lower at 2nd tier than at other tiers. However, no distinct differences in egg weight, shell weight, shell color, shell breaking strength, egg shape index, yolk weight, albumen height, haugh units were observed. Concentrations of serum CK, T-AOC, SOD, GPx and MDA, and the antibody titers did not change substantially among different tiers. Moreover, the average feather score for each individual part of the body and an overall average score for birds were not significantly different. We confidently conclude that cage tier may be a contributing factor for layer performances. These findings will be helpful for application of natural mating system in layer industry.
Dl-3-n-Butylphthalide Promotes Cardiac Function, Inhibit Oxidative Stress and Myocardial Apoptosis of Chronic Heart Failure Mice via Stimulating Nrf2/HO-1 pathway
Authors: Wang Zhongyu , Zhang Yan , Yang Chun , Yang Hongliang 
Published: September 2021

Abstract
PurposeHeart failure (HF) continues to threat the human health and plagues the world, however, there are limited effective drugs for HF. We aimed to investigate the protective effect of Dl-3-n-Butylphthalide (NBP) on myocardial injury in heart failure mice, and to study regulation mechanisms with Nrf2/HO-1/Ca2+-SERCA2a axis. MethodsSixty C57BL/6J mice were grouped into five groups using a random number table: sham group (Sham), Heart Failure model group (HF), Heart Failure+ NBP group (HN), Heart Failure+NBP+Nrf2 inhibitor (HNM), Heart Failure+ NBP + calmodulin-dependent protein kinase II (CaMKⅡ) antagonist, KN93 (HNK). The HF mice was prepared using left anterior descending coronary artery ligation. As animal model preparation, the heart function was detected using echocardiography. H&E and MASSON trichrome staining were performed to identify myocardial injury; The apoptosis of myocardial was examined by TUNEL staining assay. The levels of different oxidative stress-related proteins were measured through ELISA assay ; The reactive oxygen species and Nrf2 expression in heart tissue were observed with immunofluorescence assay. The levels of SERCA2a, calmodulin, endoplasmic reticulum stress regulatory protein and Nrf2/HO-1 protein were measured using western blotting. ResultsThe results demonstrated that NBP can significantly promote heart function, relieve the injury and inhibit cell apoptosis, meanwhile, reduce ERS injury in heart failure mice through increasing SERCA2a level and reducing Ca2+ influx. Finally, NBP was demonstrated to reduce CaMKⅡphosphorylation levels and decrease cAMP-response element binding protein phosphorylation levels, which suggested that NBP could also activate Nrf2/HO-1 signaling pathway. ConclusionsThis study identified that NPBs treatment promotes the cardiomyocytes ERS and alleviates myocardial injury in heart failure mice which is related with stimulating Nrf2/HO-1 signaling pathway, regulating Ca2+-SERCA2a and reducing Ca2+ influx.
Identification of CFHR4 Associated With Poor Prognosis of Hepatocellular Carcinoma
Authors: DING Qinglin , XU Zhigao , LI Hanluo , HU Kanghong , YE Qifa 
Published: September 2021

Abstract
Background: Hepatocellular carcinoma (HCC) is one of the most leading causes of cancer death worldwide. The 5-year survival rate of HCC patients remains low due to the lack of early-stage symptoms. Human complement factor H-associated protein 4 (CFHR4) is a critical gene that belongs to the factor H family of plasma glycoproteins, which has not been linked to HCC development. The correlations between CFHR4 and prognosis and tumor-infiltrating lymphocytes in HCC are yet unknown. The present study demonstrated the involvement of CFHR4 in HCC via data mining approaches. Results: A total of 18 upregulated and 67 down-regulated DEGs were identified. Importantly, CFHR4, which was screened from DEGs, was shown to express at a lower level in HCC tumor tissue than normal tissues. Western blotting (WB) and immunohistochemical (IHC) experiments of clinical samples further validated CFHR4 was aberrantly expressed in HCC patients; Data from TCGA showed that CFHR4 was inversely correlated with a cancer family history, histological grade, tumor node metastasis (TNM） stage, and serum AFP level of HCC patients; Univariate and multivariate analyses revealed that low expression of CFHR4 was an independent predictive marker in patients with HCC; Kaplan-Meier analysis showed that the lower expression of CFHR4 was significantly associated with the progression of HCC and poor prognosis rates. Furthermore, TIMER analysis indicated that CFHR4 expression levels had correlations with infiltrating levels of immune cells in HCC.Conclusion: CFHR4 expression was low in HCC and was significantly related to the poor prognosis of HCC and the level of immune infiltration. CFHR4 played important roles in regulating the initiation and progression of HCC and could be a potential biomarker for the diagnosis and prognosis of HCC. Methods: The expression of CFHR4 was analyzed by GEO and TCGA-LIHC database and verified by WB and IHC assay. The biological function of CFHR4 was performed by GO and KEGG enrichment analysis, and the genomic alteration of CFHR4 was investigated by cBioPortal database.The correlation between CFHR4 expression and clinical relevance was evaluated through Cox proportional hazards model, and the correlation between CFHR4 expression and tumor immune infiltrates were studied by TIMER database.
Glutathione Peroxidase 3 (GPX3) Expression Predicts the Prognosis of Numerous Malignant Tumors: A Pan-Cancer Analysis
Authors: Wang Yuetong , Fu Guotao , Chen Xueqin , Xia Zengrun , Qi Meng , Du Xiaoping , Liu Kun , Liu Qiling , Sun Na , Shi Chuandao , Zhang Rongqiang , Qu Kai 
Published: September 2021

Abstract
Background: Malignant tumor is a general term for uncontrollable growth of cells. Several studies have investigated that role of GPX3 in tumors. However, no pan-cancer analysis has be conducted to assess the diagnostic and prognostic potential of GPX3. Methods: GPX3 mRNA and protein expression profile was analyzed in the TCGA+GTEx database and CPTAC database. Kaplan-Meier survival curves and forest plots were constructed to help evaluate the impact of GPX3 on the survival and prognosis of cancer patients. Gene mutations of GPX3 were analyzed based on TMB/MSI. The correlation between GPX3 and tumor immune infiltration was assessed using TIMER2. Enrichment analysis was performed to determine tumor-related signaling pathways associated with GPX3. A prediction model for STAD was established. Results: GPX3 was downregulated in most malignant tumors, and was significantly associated with the survival and prognosis of malignant tumors, such as STAD, PAAD, COAD, etc. Moreover, GPX3 expression was positively correlated and negatively with MSI in 13 and 20 categories of tumor respectively after GPX3 expression was positively correlated and negatively with TMB in 9 and 24 tumors separately (P<0.05). A positive correlation was found between GPX3 and the infiltration level of major immune cells and Cancer-associated fibroblasts (P<0.05). The effects of GPX3 were mediated by the AMPK signaling pathway, fructose and mannose metabolism. Conclusions: This is a novel pan-cancer analysis on the relationship between GPX3 and human tumors. Findings of this research will deepen our understanding on the role of GPX3 in the development, regulation and prognosis of malignant tumors.
Transdiagnostic Alterations in Neural Emotion Regulation Circuits – Neural Substrates of Cognitive Reappraisal in Patients with Depression and Post-Traumatic Stress Disorder
Authors: Keller Micha , Mendoza-Quiñones Raul , Cabrera-Muñoz Amaray , Fuster Jorge , Virués Anette Valdés , Zvyagintsev Mikhail , Edgar James Christopher , Zweerings Jana , Mathiak Klaus 
Published: September 2021

Abstract
Background: Impaired cognitive reappraisal, associated with the social functioning and well-being of patients affected by mood or anxiety disorders, is characterized by distinct neural activation patterns across clinical populations. To date, studies dedicated to identifying common and distinct neural activation profiles need to be clarified. The aim of the present study was to investigate transdiagnostic differences and commonalities in brain activation patterns during reappraisal-mediated downregulation of emotions Methods: Cognitive reappraisal of negative images was contrasted with maintaining emotions during a control viewing condition. Brain activation in 35 patients with major depressive disorder (MDD), 20 patients with post-traumatic stress disorder (PTSD), and 34 healthy controls (HC) during cognitive reappraisal was compared. Moreover, the neural circuitry of emotion regulation in these clinical populations was examined using task-based and intrinsic functional connectivity analyses. Results: Whole-brain fMRI analyses showed less right-lateralized activation of the inferior, middle and superior frontal gyrus during cognitive reappraisal compared to viewing of negative images in MDD and PTSD patients compared to HCs. Right IFG activation was negatively correlated with the severity of anxiety and depressive symptomatology. In addition, increased seed-based connectivity of right IFG as well as increased intrinsic connectivity was observed in PTSD patients compared to HCs and MDD patients. Conclusions: FMRI results therefore suggested a common deficit of depression and anxiety symptomatology reflected by reduced activation in right IFG during cognitive reappraisal as well as diagnosis specific effects in patients with PTSD based on seed-based and intrinsic connectivity showing an overactive and hyperconnected salience network. Findings highlight the role of transdiagnostic research to identify disorder specific brain patterns as well as patterns common across disorders.
Microstructure Evolution of (MgCoNiZnCu)O High Entropy Oxides Using Ceramic Injection Molding
Authors: ZHAO Yipeng , CHEN Guoqing , LI Hongwei , FU Xuesong , ZHOU Wenlong 
Published: September 2021

Abstract
Near net shaping ceramic injection molding process of (MgCoNiZnCu)O high entropy oxides were conducted using commercial precursor oxide powders. Through ball milling, internal mixing, injection molding, solvent and thermal debinding as well as final sintering process, the ceramic products would be obtained with little machining. Compacts prepared are single rock-salt phase based on XRD and EDS Mapping results. Meanwhile, with the increasing of sintering temperature from 900 ℃ to 1050 ℃, particle diffusion rate and densification of samples becomes faster, which finally results relative density and fractured strength of sintered compacts reaching the highest (90.47 % and 77.98 MPa, respectively) in current work. The successfully synthesis of (MgCoNiZnCu)O through ceramic injection molding illustrates this near net shaping process could be a promising route for preparation of high entropy oxides.
Identification of ncRNA-Mediated Prognostic Value and Functions of MTHFD2 in Bladder Cancer
Authors: Zhang Hao , Li Rui , Deng Wanjun , Su Jinfang , Xiong Huihua 
Published: September 2021

Abstract
Background: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), one of mitochondrial enzymes, is involved in folate and nucleic acid metabolism and maintains the cellular redox balance. However, the function of MTHFD2 in bladder cancer is still poorly characterized. This study was designed to elucidate the effect and regulatory mechanism of MTHFD2 on bladder cancer cells and explore the relationships between MTHFD2 and immune cell infiltration in tumor microenvironment (TME). Methods: The data from Oncomine, TIMER, The Cancer Genome Atlas (TCGA) and The Human Protein Atlas (HPA) database were extracted to evaluate the expression of MTHFD2 and its prognostic role in pan-cancer, especially in bladder cancer. Enrichment analyses, were utilized to explore the underlying cellular mechanisms. The ncRNA regulatory axis was established by Starbase database, and the PPI network was constructed by Cytoscape software. Ultimately, the relations between the expression of MTHFD2 and immune cell infiltration in bladder cancer was indicated by TCGA and TIMER databases.Results: Our results demonstrated that MTHFD2 expression was generally up-regulated in pan-cancers and its high expression was correlated with poor prognosis of patients with bladder cancer. Specifically, our study revealed that MTHFD2 was a powerful risk factor and involved in the tumor development of bladder cancer. Furthermore, hsa_circ_0046140 and hsa_circ_0006769/miR-383-5p/MTHFD2 axis could also play a significant role in tumorigenesis. Ultimately, a strong correlation was observed between MTHFD2 expression and various immune cell infiltration, which implied that MTHFD2 might serve as an agent in tumor immunotherapy. Conclusion: MTHFD2 is widely overexpressed in pan-cancers, and its expression is related with the prognosis of patients and the multiple immune cell infiltrates in TME. Besides, hsa_circ_0046140 and hsa_circ_0006769/miR-383-5p/MTHFD2 axis are implicated with the proliferation and invasion of tumors.
Design And Validation of A Sheet Metal Clamping System For Additive Manufacturing and Post-Processing
Authors: Ferchow Julian , Bühler Marvin , Schlüssel Marcel , Zumofen Livia , Klahn Christoph , Hofmann Urs , Kirchheim Andreas , Meboldt Mirko 
Published: September 2021

Abstract
Automated clamping for post-processing of mass-customized parts is a challenging step in the laser powder bed fusion (LPBF) process chain. In this study, a novel modular sheet metal clamping system was developed that uses disposable sheet metal profiles as a universal interface for the LPBF, robotic handling, and milling processes. Based on a fundamental investigation of hybrid additive manufacturing, the sheet metal clamping system was designed to use the same interface for the LPBF and milling processes. Subsequent an end-to-end validation was performed for the entire process chain. The concept of the sheet metal clamping system gives milling tools access to a part on five to six sides. Further, the part can be accessed from the top and bottom sides, and simplifying the removal of LPBF supports. No clamping forces are induced in the LPBF part, which is especially important for filigree structures. The sheet metal clamping system’s underlying concept could be adapted to automating the LPBF process chain for applications such as prosthetic dentistry.
Control of a Lifted H2/N2 Flame by Axial and Flapping Forcing: A Numerical Study
Authors: Tyliszczak Artur , Wawrzak Agnieszka 
Published: September 2021

Abstract
The large eddy simulation (LES) method combined with the Eulerian stochastic field approach has been used to study excited lifted hydrogen flames in a stream of hot co-flow air in a configuration closely corresponding to the so-called Cabra flame. The excitation is obtained by adding to an inlet velocity profile three types of forcing ((i) axial; (ii) flapping; (iii) combination of both) with amplitude of 15% of the fuel jet velocity and frequency corresponding to the Strouhal numbers St=0.30, 0.45, 0.60 and 0.75. It is shown that such a type of forcing significantly changes the lift-off height Lh of the flame and its global shape, resulting in a flame occupying large volume or the flame, which downstream the nozzle transforms from the circular one into a quasi-planar flame. Both the Lh and their spreading angles of the flames were found to be a function of the type of the forcing and its frequency. The minimum value of Lh has been found for the case with the combination of axial and flapping forcing at the frequency close to the preferred one in the unexcited configuration. The impact of the flapping forcing manifested through a widening of the flame in the flapping direction. It was shown that the excitation can significantly increase the level of the velocity and temperature fluctuations intensifying the mixing process. The computational results are validated based on the solutions obtained for a non-excited flame for which experimental data are available.
The Association Between The Impact Factor of A Journal And The Trueness of Findings Published Therein: A Meta-Epidemiological Study
Authors: Heidenreich Andreas , Eisemann Nora , Katalinic Alexander , Huebner Joachim 
Published: September 2021

Abstract
Background: Scientists, physicians, and the general public legitimately expect scholarly publications to give true answers to study questions raised. We investigated whether findings from studies published in journals with higher Journal Impact Factors (JIFs) are more accurate than findings from studies in less-cited journals via a meta-epidemiological approach.Methods: We screened intervention reviews from the Cochrane Database of Systematic Reviews (CDSR) and sought well-appraised meta-analyses. We defined the trueness of RCT study results as their point estimates’ relative deviation from the pooled effect estimate. In addition to the JIF we considered the open-access policy of journals, the relative size of studies, and the studies’ methodical quality.Results: In 2,459 results from 446 meta-analyses, there was a positive association between a journal’s JIF and the trueness of the study results published therein (Pearson’s r for the deviation = −0.21, 95% CI −0.24 to −0.17, P < 0.001). The mean relative deviation decreased from 1.11 (SD = 0.94) in the lowest JIF quartile to 0.80 (SD = 0.75) in the top quartile (95% CI: 0.21 to 0.40, P < 0.001). Findings from larger and methodically sound studies were also more likely to be accurate. In a multiple regression analysis, the JIF proved to be the strongest determinant of trueness, independent of the covariates.Conclusions: Our results indicate that higher-impact journals act as gatekeepers in the process of science more effectively than less-cited journals. However, the fact alone that a study result is reported in a journal with a high impact factor is only a weak and impractical indicator for its accuracy.
Synthesis And Characterization of Cobalt-Zinc Spinel Ferrites For High Frequency Applications
Authors: Aman Salma , Al-Muhimeed Tahani I. , Zaki Zaki Ismail , El-Bahy Zeinhom M. , AlObaid Abeer A. , Hegazy H.H. , Khosa Rabia Yasmin , Rehman Adeela , Ejaz Syeda Rabia , Farid Hafiz Muhammad Tahir 
Published: September 2021

Abstract
Spinel ferrites are attractive for high frequency applications due to their larger direct current (dc) resistivity and low dielectric loss. In the present work, Co0.6Zn0.4HoxFe2-xO4 (x = 0.00 and 0.1) spinel ferrites were prepared by sol-gel method. The X-ray diffraction pattern showed that both samples had cubic spinel structure, while in sample (x = 0.1), the secondary phase (HoFeO3) was also observed. The dc resistivity was increased with the addition of holmium ions. As the temperature increased, the dc resistivity was decreased by proving their semiconducting nature. The dielectric properties were also measured as a function of temperature and frequency. The sample which was composed by the substitution of holmium ions contained low value of dielectric loss. The magnetic properties were also experimentally measured by applying the field up to 2000 oersted. The small area covered by hysteresis loop proved that both samples possessed soft nature of magnetic materials.
Terahertz Driven Ultrafast Energy Dissipation in Aqueous Ionic Solutions
Authors: Balos Vasileios , Kaliannan Naveen , Elgabarty Hossam , Wolf Martin , Kühne Thomas , Sajadi Mohsen 
Published: September 2021

Abstract
Solvation of ions changes the physical, chemical and thermodynamic properties of water. The microscopic origin of this process is believed to be the ion-induced perturbation in the structure and dynamics of the hydrogen (H)-bonding network of water. Here, we provide microscopic insight on the local structural deformation of the H-bonding network of water by ions, via investigating the dissipation of external energy in salt solutions by a novel time-resolved terahertz (THz)-Raman spectroscopy. We resonantly drive the low-frequency rotational dynamics of water molecules by intense THz pulses and probe the Raman response of their intermolecular translational motions. We find that the intermolecular rotational-to-translational energy transfer is enhanced by highly-charged cations and it is drastically reduced by highly-charged anions, scaling with the ion surface charge density and concentration. Our molecular dynamics simulations further reveal that the water-water H-bond strength between the first and the second solvation shells of cations (anions) increases (decreases), signifying the opposite effects of cations and anions on the local structure of water. The impact of ion polarity on the ultrafast energy dissipation in water, resembles the effect of ions on stabilization and denaturation of proteins.