bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vivo Biological Evaluation of Biodegradable Nanofibrous Membranes Incorporated with Antibiofilm Compounds
Authors: Geremias Thaise C. , Sartoretto Suelen C. , Batistella Marcos A. , Souza Antônio A. Ulson de , Alves Adriana T. N. N. , Uzeda Marcelo J.P. , Calasans-Maia Jose , Montemezzi Pietro , Mourão Carlos Fernando de Almeida Barros , Calasans-Maia Monica 
Published: July 2021

Guided bone regeneration involves excluding non-osteogenic cells from the surrounding soft tissues and allowing osteogenic cells originating from native bone to inhabit the defect. The aim of this work was to fabricate, analyze antibiofilm activity and evaluate in vivo biological response of poly (lactic-co-glycolic acid) (PLGA) electrospun membranes incorporated with tea tree oil and furan-2(5H)-one. Samples were exposed to Streptococcus mutans culture and after 48 h incubation, biofilm was evaluated by colony forming units (CFU/mL) followed by scanning electron microscopy. Additionally, seventy-five Balb-C mice were divided into five experimental groups for subcutaneous implantation: tea tree oil loaded PLGA electrospun fiber membrane, furanone loaded PLGA electrospun fiber membrane, neat PLGA electrospun fiber membrane, a commercially available PLGA membrane –Pratix® and Sham (no-membrane implantation). Post implantation period of each experimental group (1, 3 and 9 weeks), samples were collected and processed for by histological descriptive and semiquantitative evaluation. Results showed a significant reduction of bacterial attachment on tea tree oil and furan-2(5H)-one incorporated membranes. Macrophage counts were significant found in all the materials implanted, although giant cells were predominantly associated with electrospun fiber membranes. The incorporation of antibiofilm compounds in nanofibers membranes did not incite inflammatory response significantly different in comparison with pure PLGA electrospun membranes, indicating its potential for development of novel functionalized membranes targeting the inhibition of bacterial biofilms on membrane-grafting materials.
Demandas e expectativas em relação à escrita acadêmica: uma análise de narrativas de estudantes calouros
Authors: Silva Elizabeth Maria da , Castanheira Maria Lúcia 
Published: July 2021

Neste artigo, objetiva-se examinar demandas e expectativas quanto à produção escrita acadêmica, sob a ótica de estudantes do curso de Pedagogia de uma universidade federal brasileira. Trata-se de uma pesquisa ancorada nos fundamentos teórico-metodológicos dos estudos dos letramentos, particularmente dos letramentos acadêmicos, baseando-se também nos conceitos de eventos e práticas de letramento. O corpus, explorado à luz da abordagem qualitativa e da perspectiva etnográfica, é constituído por registros de transcrição de entrevistas semiestruturadas, realizadas com estudantes calouras do curso referido, que integram um banco de dados de uma pesquisa mais ampla voltada para os significados dos letramentos acadêmicos em contextos específicos. A análise das demandas e expectativas para a produção escrita acadêmica evidencia a recorrência de duas maneiras de se estabelecer relações com a escrita, nesse contexto: (1) a não apresentação de orientações quanto ao modo de escrever, ao se propor uma atividade de escrita aos alunos e (2) a apresentação de feedbacks genéricos sobre a escrita feita pelos alunos. Essas maneiras de se lidar com a escrita acadêmica parecem dificultar o processo de familiarização dos discentes com as formas de escrever demandadas na universidade, visto que, como ainda são recém-ingressos, desconhecem provavelmente as especificidades da escrita acadêmica.
PENERAPAN METODE SMART DALAM SISTEM PENDUKUNG KEPUTUSAN PEMBERIAN SANKSI PELANGGARAN TATA TERTIB SISWA (Studi Kasus: SMK Negeri 1 Pujut)
Authors: Zaen Mohammad Taufan Asri , Janiah Baiq Daniatan , Fadli Sofiansyah 
Published: July 2021

Sekolah Menengah Kejuruan (SMK) Negeri 1 Pujut merupakan sekolah kejuruan yang memiliki siswa cukup banyak untuk ukuran sekolah yang berada diwilayah pedesaan. SMK Negeri 1 Pujut memiliki beberapa peraturan dan tata tertib yang harus ditaati oleh semua siswa tetapi tidak jarang peraturan dan tata tertib tersebut dilanggar oleh beberapa siswa. Penelitian ini bertujuan merancang sebuah sistem pendukung keputusan pemberian sanksi pelanggaran tata tertib siswa menggunakan metode Simple Multi Attributte Rating Technique (SMART). Pada sistem yang akan dirancang tersebut memiliki beberapa kriteria penilaian dan penjumlahan yang terbobot untuk setiap alternatif-alternatif pada setiap atribut atau kriteria pelanggaran yang ada. Setiap pelanggaran yang dilakukan oleh siswa dapat diproses dengan cepat dan akurat dengan sanksi dan tindakan yang telah ditentukan, memiliki perhitungan yang sama antara perhitungan manual dan perhitungan pada sistem sehingga dapat membantu guru BK dalam proses pelaporan kepada kepala sekolah di SMK Negeri 1 Pujut.
Accretion onto Stars in the Disks of Active Galactic Nuclei
Authors: Dittmann Alexander J. , Cantiello Matteo , Jermyn Adam S. 
Published: July 2021

Abstract
Disks of gas accreting onto supermassive black holes are thought to power active galactic nuclei (AGN). Stars may form in gravitationally unstable regions of these disks, or may be captured from nuclear star clusters. Because of the dense gas environment, the evolution of these embedded stars can diverge dramatically from those in the interstellar medium. This work extends previous studies of stellar evolution in AGN disks by exploring a variety of ways in which accretion onto stars in AGN disks may differ from Bondi accretion. We find that tidal effects from the supermassive black hole significantly alter the evolution of stars in AGN disks, and that our results do not depend critically on assumptions about radiative feedback on the accretion stream. Thus, in addition to depending on the ambient density and sound speed, the fate of stars in AGN disks depends sensitively on the distance to and mass of the supermassive black hole. This affects the location in the disk in which stellar explosions occur, where compact remnants form and potentially merge to produce gravitational waves, and where different types of chemical enrichment take place.
Dose Response in the Subthreshold Nanosecond Laser Trial in Early Stages of AMD: A LEAD Study Report
Authors: Cohn Amy C. , Runciman Jim , Hodgson Lauren A.B. , Caruso Emily , Arnold Jennifer J. , Chen Fred K. , Chakravarthy Usha , Heriot Wilson J. , Guymer Robyn H. , Wu Zhichao ,   For the LEAD Study Group
Published: July 2021

BACKGROUND AND OBJECTIVE:
To examine the association between treatment parameters and the progression to late age-related macular degeneration (AMD) in the Laser Intervention in Early Stages of Age-Related Macular Degeneration (LEAD) study, a randomized, controlled trial of a subthreshold nanosecond laser (SNL) for slowing disease progression in the early stages of AMD.

PATIENTS AND METHODS:
The association between treatment parameters early in the trial period for participants in the SNL arm of the LEAD study and time to develop late AMD during the 3-year trial duration was examined. Parameters included treatment energy at the baseline and 6-month visits and the number of laser spots visible on fundus autofluorescence (FAF) imaging taken at 6 and 12 months (taken as a proxy measure of early, adequate delivery of the laser treatment at the baseline and 6-month visits, respectively).

RESULTS:

A multivariable analysis revealed there were no significant associations between time to develop late AMD and number of FAF-visible laser spots at 6-months (adjusted
P
= .537) nor laser energy used at baseline (adjusted
P
= .910). No significant associations were also observed when evaluating FAF-visible spots at 12-months (adjusted
P
= .107) and the average laser energy used at baseline and 6 months (adjusted
P
= .558).

CONCLUSIONS:
This study did not find any evidence to suggest that there was a dose response for the effect of laser treatment using these treatment parameters on the progression of AMD.

[
Ophthalmic Surg Lasers Imaging Retina.
2021;52:380–386.]
Articuler collaboration et représentation en gouvernance collaborative : une perspective communicationnelle
Authors: Benoît-Barné Chantal , Robichaud Daniel 
Published: July 2021

Cet article rend compte de l’étude d’une initiative de gouvernance collaborative destinée à introduire des mesures innovantes de sécurité routière dans une juridiction canadienne. Il montre comment une attention aux pratiques de communication et à leurs effets constitutifs permet de saisir de quelles manières les acteurs gèrent l’un des principaux défis connus de ce type d’initiative : celui d’affronter les tensions inévitables entre l’impératif de représenter les intérêts de son organisation d’appartenance, et de collaborer positivement à la productivité du groupe. L’article décrit les manifestations de ces tensions et dégage deux types de pratiques communicatives permettant de composer avec elles dans le cas d’une collaboration réussie.
Efficacy and Safety of Thalidomide in Patients with Complicated Central Nervous System Tuberculosis: A Systematic Review and Meta-Analysis
Authors: Panda Prateek Kumar , Panda Pragnya , Dawman Lesa , Sihag Rakesh Kumar , Sharawat Indar Kumar 
Published: July 2021

ABSTRACT.
Thalidomide, an anti-inflammatory and immunomodulatory agent, has a potential role in cases with central nervous system tuberculosis (CNS-TB) with paradoxical reactions. Although several articles have described the use of thalidomide in CNS-TB, no systematic review has been performed in this regard. Different electronic databases were searched for articles describing the use of thalidomide in patients with CNS-TB. For determining pooled estimates in the quantitative review, studies with a minimum sample size of 5 were only considered, whereas for qualitative synthesis even single case reports were included. Fixed or random effect models were used suitably depending on the degree of heterogeneity. Fourteen articles describing a total of 107 patients (98 children and 9 adults) were selected from 156 records. A favorable clinical response was observed in 89% of patients with CNS-TB who had paradoxical reactions refractory to corticosteroids. Majority of the studies used a dose of 2–6 mg/kg/day and around 24% suffered from at least one adverse effect, with a mortality of 5%. Predominant adverse effects were rash (9.5%), neuropathy (6%), and elevated liver transaminases (9.5%). Only one placebo-controlled trial has been performed till now, which showed that high-dose thalidomide has numerous adverse effects, without any clinically significant improvement as compared with placebo. While in HIV-positive patients with TB-immune reconstitution inflammatory syndrome thalidomide was helpful in around 82% of cases. Low-dose thalidomide is helpful in patients with CNS-TB who had a paradoxical reaction and unresponsive to corticosteroids. Large, randomized trials are needed to provide more concrete information regarding the safety and efficacy of thalidomide.
Tuberculous Encephalitis May Be Undetectable on Magnetic Resonance Imaging but Detectable on 18F-Fluorodeoxyglucose Positron Emission Tomography–Computed Tomography
Authors: Maramattom Boby Varkey , Santhamma Shagos Gopalan Nair 
Published: July 2021

ABSTRACT.
Neurotuberculosis (NT) continues to be a global health problem with severe morbidity and mortality. The manifestations of NT are well-known and encompass forms such as meningitis, tuberculomas, military tuberculosis, ventriculitis, and brain abscess. Data of all patients with central nervous system tuberculosis who underwent magnetic resonance imaging (MRI) and/or 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography–computed tomography (PET-CT) were analyzed. Over a 7-year period (2014–2021), we encountered three patients who had dense neurological deficits and 18F-FDG PET-CT results suggesting focal cortical encephalitis. 18F-FDG PET-CT demonstrated focal hypermetabolism involving focal–regional areas of the left hemisphere that corresponded to clinical deficits in two of the three patients. Follow-up 18F-FDG PET-CT showed improvement in cortical hypermetabolism in all three patients that corresponded with clinical improvement. MRI of the brain with contrast showed subtle leptomeningeal enhancement in these areas, along with other features of NT, but it could not detect cortical involvement. A literature review also revealed some previous descriptions that seemed to be consistent with tuberculous encephalitis (TbE). TbE seems to be a distinct subset of NT and may coexist with other features of NT or disseminated tuberculosis. It may be detected by 18F-FDG PET-CT even when brain MRI does not show any evident abnormality to explain a focal neurological deficit. 18F-FDG PET-CT can be considered during the evaluation and monitoring of NT to detect TbE. The presence of TbE may affect the prognosis and treatment duration of NT.
PERFIL DE PACIENTES EM TERAPIA NUTRICIONAL ENTERAL EM INSTITUIÇÃO DE ALTA COMPLEXIDADE
Authors: Barbosa Jaqueline Almeida Guimaraes , Ferreira Lariza Emanuele Alcântara , De Castro Ana Luísa , Donoso Miguir Terezinha Vieccelli 
Published: July 2021

Objetivo: avaliar os perfis sociodemográfico e clínico de pacientes em terapia nutricional enteral em uma instituição de alta complexidade. Método: trata-se de um estudo quantitativo, descritivo, observacional e transversal. Analisaram-se dados de pacientes em terapia nutricional enteral ao longo de sete meses, considerando-se variáveis sociodemográficas e clínicas e a via de infusão da dieta. Realizaram-se análises estatísticas descritivas das frequências absoluta, relativa e média. Resultados: registrou-se que 614 pacientes usaram a terapêutica, sendo que 55,0% eram do sexo masculino e 39,9% tinham idade acima de 60 anos. Verifica-se que os diagnósticos clínicos mais prevalentes variaram de acordo com as faixas etárias, com destaque para o câncer (25,2%). Aponta-se que a via de infusão predominante foi a sonda nasoenteral (78,6%). Conclusão: entende-se que a terapia nutricional enteral se mostrou necessária em todas as faixas etárias e em vários diagnósticos clínicos, principalmente, para idosos e pessoas em tratamento oncológico. Avalia-se que os achados contribuem para o planejamento assistencial e o conhecimento em Enfermagem.Descritores: Terapia Nutricional; Nutrição Enteral; Cuidados de Enfermagem; Perfil de Saúde; Planejamento de Assistência ao Paciente; Serviço Hospitalar de Enfermagem Descriptors: Nutritional Therapy; Enteral Nutrition; Nursing Care; Health Profile; Patient Care Planning; Nursing Service Hospital.
Uso do Cateter Central de Inserção Periférica em Pacientes Adultos: uma perspectiva para a enfermagem oncológica
Authors: Pereira René Rodrigues , Benício Givanildo Carneiro , Cavalcante Sara Lourrane Carneiro de Andrade , Do Vale Aurora Pinheiro , Rocha Dayane Dos Reis Araújo 
Published: July 2021

Objetivo: Identificar a perspectiva para a enfermagem oncológica da utilização do PICC em pacientes adultos. Método: Revisão integrativa estruturada por estudos indexados nas bases de dados LILACS, MEDLINE e SciELO, incluindo artigos publicados entre os anos de 2015 e 2019, que abrangessem a experiência do PICC em pacientes adultos oncológicos. Resultados: Identificou-se inicialmente um total de 140 publicações, das quais nove compuseram a amostra final. O conteúdo permitiu a estruturação de quatro subtemas: comparação com outros dispositivos de acesso vascular; percepções de médicos e enfermeiros sobre o acesso venoso; experiência do paciente; e eventos adversos relacionados ao cateter. Assim, epilogou-se o aproveitamento de PICCs para o tratamento anticâncer, obtendo uma imagem clara do cenário de sua utilização na assistência de enfermagem oncológica. Conclusão: O PICC cresceu no escopo da enfermagem oncológica como tecnologia para acesso vascular. Entretanto, a perenidade do seu sucesso está inegavelmente vinculada à classificação adequada do cliente quanto à vulnerabilidade em desenvolver complicações e aos cuidados de enfermagem pós-inserção. A depender da preferência pessoal de oncologistas e usuários, o cenário futuro do PICC no tratamento de pacientes adultos com câncer é incerto. Descritores: Neoplasias. Oncologia. Cateterismo Venoso Periférico. Cateterismo Venoso Central. Enfermagem Oncológica. Cuidados de Enfermagem.
‘Follow the dog’ – Creating arts-based, supportive and relational spaces to facilitate in a purposeful discovery of knowledge
Authors: Weerman Alie , Metze Rosalie 
Published: July 2021

‘Follow the dog’ – Creating arts-based, supportive and relational spaces to facilitate in a purposeful discovery of knowledge
Dutch social policies are aimed at the integration and participation of all people. This creates challenges for persons with a mental vulnerability and their neighbourhoods. Five municipalities in the province of Flevoland asked us to help them improve the move from protected living to living in the neighbourhood. We used an arts-based participatory action research design and we followed ‘hot topics’, topics that sparked people’s energy and emotion, and which led to empowerment and participation. Focusing on these topics, which initially might not seem to be closely connected to the main research topic, might produce more information, and energy to take action on it, rather than rigidly sticking with the initial research topics. In this article, we focus on the first phases of the project. The emotions that people with mental vulnerabilities expressed when talking about their dogs, led us to the core of what really mattered to them in terms of inclusive living and participation. The dog functioned as an unexpected ‘hot topic’. In a symbolic sense, ‘the dog’ stands for a diverse range of lifeworld topics that can act as a creative catalyst for social change.
Cancer du sein chez les Rwandaises en âge de procréer du district sud de Kayonza : facteurs influençant les pratiques de dépistage
Authors: Igiraneza Pierre Céléstin , Omondi Lilian A. , Nikuze Bellancille , Uwayezu Marie Goretti , Fitch Margaret , Niyonsenga Gaudence 
Published: July 2021

Introduction : Au Rwanda, le cancer du sein est une grande préoccupation pour la santé des femmes puisque la plupart des diagnostics sont faits à un stade avancé de la maladie. On sait pourtant que les pratiques de dépistage du cancer du sein permettent d’accélérer le diagnostic. Objectif : Évaluer les facteurs qui influencent les pratiques de dépistage du cancer du sein chez les femmes en âge de procréer habitant le district de Kayonza, au Rwanda. Méthodologie : Une étude quantitative a été menée dans quatre centres de santé au sud du district de Kayonza auprès de 246 femmes de 16 à 49 ans. Un questionnaire structuré, prétesté et autoadministré a été utilisé pour évaluer l’influence des connaissances, des centres de santé et des facteurs socioéconomiques et culturels sur les pratiques de dépistage du cancer du sein chez les femmes dans le sud de Kayonza. Résultats : Parmi les répondantes, 55,5 % avaient une connaissance moyenne des facteurs de risque du cancer du sein, et 60,2 % sur l’incidence du dépistage du cancer du sein. On a constaté que 28 % étaient familiarisées avec l’auto-examen des seins (AES) et 16,4 % avec l’examen clinique des seins (ECS) et l’échographie mammaire. Au cours des deux années précédentes, les réponses entourant les pratiques de dépistage du sein ont révélé que 72 % des répondantes n’avaient jamais réalisé d’AES et que 81,3 % n’avaient jamais passé d’ECS ou d’échographie mammaire. Pour 30,4 % des répondantes, l’information sur le dépistage du cancer du sein provenait principalement de la radio. Des relations significatives avec les pratiques de dépistage du cancer du sein sont ressorties pour l’âge et l’état matrimonial. Conclusion : L’étude témoigne du peu de connaissances sur le cancer du sein, le dépistage et les pratiques relatives au dépistage de cette maladie. Il est donc nécessaire de promouvoir la sensibilisation au cancer du sein et de créer un programme qui puisse améliorer les connaissances et les pratiques en matière de dépistage afin d’améliorer la santé des femmes du sud de Kayonza.
Potential Liquid Fertilizer Made from Goat Feces to Improve Vegetable Product
Authors: Sunaryo Yacobus , Theresia Darini Maria , Ratri Cahyani Vita , Purnomo Djoko 
Published: July 2021

This study was carried out to examine the production of liquid fertilizer made from goat feces (LFGF) as well as the potency of LFGF for increasing plant growth and yield of vegetables. The study was conducted through 3 studies. The first study was begun with compiling a formulation for LFGF. The selected-raw-material was goat feces added with sugar and ZA, as well as EM (Lactobacillus sp., Actinomycetes sp., Streptomyces sp. and Yeast). The experimental results indicated that an increase in the concentration of ZA resulted in an increase in the total N and S content, as well as an increase EC of LFGF. Increased sugar concentration results in a decrease in pH and an increase in lactic acid content, whereas an increase in ZA decreases the formation of acetic acid. The use of sugar 25 g L−1 water and ZA 50 g L−1 water could produce the best quality of LFGF. The second study was to examine the selected LFGF combined with AB-Mix nutrient solution on the growth and yield of three types of leaf vegetables which were cultivated hydroponically. The results indicated that LFGF can potentially replace AB-Mix fertilizer by up to 50% in hydroponic vegetable cultivation. The third study was to examine the selected LFGF as nutrients availability of mustard that was cultivated in pots, given through planting media with a concentration of 1:40 L−1 water (EC 2300 μS cm−1). It shows that LFGF has the potential to increase the growth and yield of mustard plants in pots.
Study of three days duration coupling between jets in South América
Authors: Ramos Emily Claudia Pereira , Machado Luiz Gabriel Cassol , Nunes André Becker 
Published: July 2021

It can be understood by coupling between jets when Upper-Level Jet (ULJ) superimposes the Low-Level Jet (L LJ). The literature shows that such couplings tend to generate or intensify surface instabilities. Thus, the objective of this study was to analyze the synoptic configuration and the coupling between the jets associated with storms during the period of October 28-30, 2019, when instabilities hit southern Brazil causing intense precipitation and several damages. This work was carried out through the analysis of meteorological fields employing ERA5 reanalysis data and GOES-16 satellite imagery. The coupling between jets was verified in the three days of study. Upward vertical movements at 500 hPa was observed in the same area of occurrence of the upper level difluent flow, as well as an intense 850 hPa northerly flow, a large amount of moisture due to the action of the Northwestern Argentinean Low, and the presence of a frontal system between Uruguay and RS, except on the first day. Storms developed east (downstream) of the area where the coupling took place. The coupling was observed before and during the development of the mesoscale convective systems, and its dissipation occurred simultaneously with the storm. However, on the 30th, the peak of coupling did not occur together with the most intense phase of the system, it occurred before.