bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Associations of Lipid Profiles With Cardiovascular Diseases and Death in a 10-Year Prospective Cohort Study
Authors: Dong Jiayi , Yang Song , Zhuang Qian , Sun Junxiang , Wei Pengfei , Zhao Xianghai , Chen Yanchun , Chen Xiaotian , Li Mengxia , Wei Lai , Chen Changying , Fan Yao , Shen Chong 
Published: November 2021

Background: Dyslipidemia is one of the modifiable risk factors for cardiovascular diseases (CVD). Identifying subjects with lipid abnormality facilitates preventative interventions.Objectives: To evaluate the effects of lipid indices on the risks of ischemic stroke (IS), coronary heart disease (CHD), CVD, all-cause death, and CVD death.Methods: The cohort study of 4,128 subjects started in May 2009 and followed up to July 2020. Restricted cubic spline (RCS) regression analysis was used to explore the dose-response relationship between lipid indices with outcomes. Cox proportional hazard regression analysis was used to estimate the association with a hazard ratio (HR) and 95% CI.Results: RCS analysis showed that there were significant linear associations of TG with IS, non-high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (ApoB), and total cholesterol (TC)/HDL-C ratio with all-cause death, non-HDL-C and RC with CVD death, and significant non-linear associations of ApoB with IS and CVD, TC, LDL-C, ApoAI, and TC/HDL-C ratio with CHD, and TC with all-cause death (all P &lt;0.1). Cox regression analysis revealed that subjects with TC &lt;155 mg/dl (vs. 155–184 mg/dl), &gt; 185 mg/dl (vs. 155–184 mg/dl), and ApoB &lt;0.7 g/l (vs. ≥0.7 g/l) had higher risks of CHD (P &lt; 0.05), the adjusted HRs (95% CIs) were 1.933 (1.248–2.993), 1.561 (1.077–2.261), and 1.502 (1.01–2.234), respectively. Subjects with ApoAI &gt; 2.1 g/l (vs. 1.6–2.1 g/l) and TG &lt;80 mg/dl (vs. 80–177 mg/dl) had higher risks of CVD and all-cause death (P &lt; 0.05), the adjusted HRs (95% CIs) were 1.476 (1.031–2.115) and 1.234 (1.002–1.519), respectively.Conclusions: Lower or higher levels of TC, higher level of ApoAI, and lower level of ApoB were associated with increased risks of CVD, and lower level of TG was associated with increased all-cause death. Maintaining optimal lipid levels would help to prevent CVD and reduce mortality.
ΔPCO2 and ΔPCO2/C(a−cv)O2 Are Not Predictive of Organ Dysfunction After Cardiopulmonary Bypass
Authors: Zhang Sheng , Zheng Dan , Chu Xiao-Qiong , Jiang Yong-Po , Wang Chun-Guo , Zhang Qiao-Min , Qian Lin-Zhu , Yang Wei-Ying , Zhang Wen-Yuan , Tung Tao-Hsin , Lin Rong-Hai 
Published: December 2021

Background: Cardiac surgery is associated with a substantial risk of major adverse events. Although carbon dioxide (CO2)-derived variables such as venous-to-arterial CO2 difference (ΔPCO2), and PCO2 gap to arterial–venous O2 content difference ratio (ΔPCO2/C(a−cv)O2) have been successfully used to predict the prognosis of non-cardiac surgery, their prognostic value after cardiopulmonary bypass (CPB) remains controversial. This hospital-based study explored the relationship between ΔPCO2, ΔPCO2/C(a−cv)O2 and organ dysfunction after CPB.Methods: We prospectively enrolled 114 intensive care unit patients after elective cardiac surgery with CPB. Patients were divided into the organ dysfunction group (OI) and non-organ dysfunction group (n-OI) depending on whether organ dysfunction occurred or not at 48 h after CPB. ΔPCO2 was defined as the difference between central venous and arterial CO2 partial pressure.Results: The OI group has 37 (32.5%) patients, 27 of which (23.7%) had one organ dysfunction and 10 (8.8%) had two or more organ dysfunctions. No statistical significance was found (P = 0.84) for ΔPCO2 in the n-OI group at intensive care unit (ICU) admission (9.0, 7.0–11.0 mmHg), and at 4 (9.0, 7.0–11.0 mmHg), 8 (9.0, 7.0–11.0 mmHg), and 12 h post admission (9.0, 7.0–11.0 mmHg). In the OI group, ΔPCO2 also showed the same trend [ICU admission (9.0, 8.0–12.8 mmHg) and 4 (10.0, 7.0–11.0 mmHg), 8 (10.0, 8.5–12.5 mmHg), and 12 h post admission (9.0, 7.3–11.0 mmHg), P = 0.37]. No statistical difference was found for ΔPCO2/C(a−cv)O2 in the n-OI group (P = 0.46) and OI group (P = 0.39). No difference was detected in ΔPCO2, ΔPCO2/C(a−cv)O2 between groups during the first 12 h after admission (P &gt; 0.05). Subgroup analysis of the patients with two or more failing organs compared to the n-OI group showed that the predictive performance of lactate and Base excess (BE) improved, but not of ΔPCO2 and ΔPCO2/C(a−cv)O2. Regression analysis showed that the BE at 8 h after admission (odds ratio = 1.37, 95%CI: 1.08–1.74, P = 0.009) was a risk factor for organ dysfunction 48 h after CBP.Conclusion : ΔPCO2 and ΔPCO2/C(a−cv)O2 cannot be used as reliable indicators to predict the occurrence of organ dysfunction at 48 h after CBP due to the pathophysiological process that occurs after CBP.
Higher Incidence of Stroke in Severe COVID-19 Is Not Associated With a Higher Burden of Arrhythmias: Comparison With Other Types of Severe Pneumonia
Authors: Jirak Peter , Shomanova Zornitsa , Larbig Robert , Dankl Daniel , Frank Nino , Seelmaier Clemens , Butkiene Dominyka , Lichtenauer Michael , Mirna Moritz , Strohmer Bernhard , Sackarnd Jan , Hoppe Uta C. , Sindermann Jürgen , Reinecke Holger , Frommeyer Gerrit , Motloch Lukas J. , Pistulli Rudin 
Published: November 2021

Aims: Thromboembolic events, including stroke, are typical complications of COVID-19. Whether arrhythmias, frequently described in severe COVID-19, are disease-specific and thus promote strokes is unclear. We investigated the occurrence of arrhythmias and stroke during rhythm monitoring in critically ill patients with COVID-19, compared with severe pneumonia of other origins.Methods and Results: This retrospective study included 120 critically ill patients requiring mechanical ventilation in three European tertiary hospitals, including n =60 COVID-19, matched according to risk factors for the occurrence of arrhythmias in n = 60 patients from a retrospective consecutive cohort of severe pneumonia of other origins. Arrhythmias, mainly atrial fibrillation (AF), were frequent in COVID-19. However, when compared with non-COVID-19, no difference was observed with respect to ventricular tachycardias (VT) and relevant bradyarrhythmias (VT 10.0 vs. 8.4 %, p = ns and asystole 5.0 vs. 3.3%, p = ns) with consequent similar rates of cardiopulmonary resuscitation (6.7 vs. 10.0%, p = ns). AF was even more common in non-COVID-19 (AF 18.3 vs. 43.3%, p = 0.003; newly onset AF 10.0 vs. 30.0%, p = 0.006), which resulted in a higher need for electrical cardioversion (6.7 vs. 20.0%, p = 0.029). Despite these findings and comparable rates of therapeutic anticoagulation (TAC), the incidence of stroke was higher in COVID-19 (6.7.% vs. 0.0, p = 0.042). These events also happened in the absence of AF (50%) and with TAC (50%).Conclusions: Arrhythmias were common in severe COVID-19, consisting mainly of AF, yet less frequent than in matched pneumonia of other origins. A contrasting higher incidence of stroke independent of arrhythmias also observed with TAC, seems to be an arrhythmia-unrelated disease-specific feature of COVID-19.
A Case Report: An Elderly Male Patient With Takayasu Arteritis After Coronary Artery Bypass Grafting
Authors: Yu Huaitao , Liu Wenzhao , Zhang Yuan , Yan Xuefang , Li Na , Ti Yun , Bu Peili 
Published: November 2021

Background: Takayasu arteritis is a rare chronic granulomatous inflammation involving the aorta and its main branches. In this report, we describe an extremely rare elderly male patient with Takayasu arteritis (TA) after coronary artery bypass grafting (CABG).Case Summary: A 61-year-old male patient with persistent precordial pain underwent angiography. Vascular murmurs could be heard in carotid artery and bilateral renal artery by auscultation. Laboratory parameters showed high Erythrocyte Sedimentation Rate (ESR) and C-reactive protein (CRP). CT coronary angiography showed multiple stenoses of aorta and its main branches, such as carotid and renal artery involvement. Coronary angiography showed that the coronary artery had multiple branch stenoses, the left anterior descending artery (LAD) had severe stenosis, the distal end of which was reversed to the right coronary artery (RCA), and the RCA was completely occluded. Because of the high level of markers of inflammatory activity, the patient began to take glucocorticoid. Although the patient still had multibranch stenosis of coronary artery, considering the previous CABG operation history, surgery, and interventional therapy of the patient were not feasible, the patient was given conservative drug for further treatment. After treatment, the inflammatory index was significantly descended, and N terminal-pro Brain natriuretic peptide (NT-pro BNP) was decreased.Discussion: A rare case of an elderly male patient with Takayasu arteritis after coronary artery bypass grafting was reported. In addition to hypertension, hyperlipidemia, and other risk factors, coronary artery involvement caused by TA may be a major cause of aggravation of symptoms in patients with acute myocardial infarction (AMI), especially after CABG.
Effect of Sodium Tanshinone IIA Sulfonate Injection on Blood Lipid in Patients With Coronary Heart Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Zhou Hufang , Zhao Ying , Peng Wenhua , Han Wenbo , Wang Zichen , Ren Xiaoxia , Wang Dayang , Pan Guozhong , Lin Qian , Wang Xian 
Published: November 2021

Background: Lipid-lowering therapy is very important in secondary prevention of coronary heart disease (CHD). In many clinical trials, it has been found that Sodium Tanshinone IIA Sulfonate Injection (STS) have a lipid-lowering effect while reducing major cardiovascular events in patients with CHD. However, up to now, there is no system review on the effectiveness and safety of STS affecting blood lipids.Purpose: The aim of this review is to systematically assess the effects of STS on blood lipid levels in patients with CHD.Methods: Until Mar 2021, five databases (PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database) were searched for randomized controlled trials (RCTs) about STS treating patients with CHD. Risk bias was assessed for included studies according to Cochrane handbook. The primary outcome was total cholesterol (TC). The secondary outcomes were triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and adverse events (AEs).Results: A total of 27 trials including 2,445 CHD patients met the eligibility criteria. Most trials had high risks in random sequence generation, allocation concealment, blinding of patients and personal, blinding of outcome assessment. Meta-analysis showed that STS significantly reduced plasma TC levels [MD = −1.34 mmol/l 95% CI (−1.59, −1.09), p &lt; 0.00001, I2 = 98%], TG levels [MD = −0.49 mmol/l 95% CI (−0.62, −0.35), p &lt; 0.00001, I2 = 97%], LDL-c levels [MD = −0.68 mmol/l (−0.80, −0.57), p &lt; 0.00001, I2 = 96%], increased HDL-c levels [MD = 0.26 mmol/l (0.15, 0.37), p &lt; 0.00001, I2 = 97%], without increasing the incidence of AEs [RR = 1.27 95% CI (0.72, 2.27), p = 0.94, I2 = 0%] in patients with CHD.Conclusion: STS can safely and effectively reduce plasma TC, TG and LDL-c levels in patients with CHD, and improve plasma HDL-c levels. However, these findings require careful recommendation due to the low overall quality of RCTs at present. More multi-center, randomized, double-blind, placebo-controlled trials which are designed follow the CONSORT 2010 guideline are needed.
Exploring the Pool of Pathogenic Variants of Amelogenesis Imperfecta: An Approach to the Understanding of Its Genetic Architecture
Authors: Urzúa Blanca , Ortega-Pinto Ana , Adorno-Farias Daniela , Morales-Bozo Irene , Rojas-Flores Sandra , Briones-Marín Diego , Lepiman-Torres Constanza 
Published: December 2021

Objective: To identify which genes are associated with the clinical phenotype of amelogenesis Imperfecta (AI) and to elucidate which of these genes participate in the determination of isolated and syndromic forms.Methods: In this review, all data on mutations described in AI-related genes were obtained from HGMD® Professional. The data in relation to the mutations, inheritance, phenotype, type of AI and country were supplemented with information from the literature. The identity codes and frequency values were obtained from the dbSNP, ClinVar and OMIM databases. The percentage of specificity (PE) was determined for each gene.Results: HGMD® describes 27 genes involved in AI, which we propose to group into 5 categories: (1) genes whose mutations are associated only with isolated AI, (2) genes whose mutations cause only syndromic AI, (3) genes with both mutations that cause isolated AI and mutations responsible for other pathologies, (4) genes with mutations responsible for syndromic AI and mutations that cause other pathologies, and (5) genes with mutations that cause isolated AI and mutations that cause AI associated with syndromes and other pathologies. Using the PE calculation, the genes were ranked into 5 specificity groups. The genes of category 1 are specific for isolated AI, while the genes of categories 2 and 4 are non-specific. Interestingly, we observed that mutations in some genes were associated with different types of cancer.Conclusion: The ACP4, AMTN, MMP20, ODAPH, RELT, SLC24A4 and SP6 genes participate in causing isolated AI, and the CNNM4, DLX3 and FAM20A genes participate in causing syndromic forms of AI.
Relationship Between Altimetric Quality and Along-Track Spatial Resolution for iGNSS-R Sea Surface Altimetry: Example for the Airborne Experiment
Authors: Liu Zongqiang , Zheng Wei , Wu Fan , Kang Guohua , Sun Xuezhi , Wang Qiang 
Published: November 2021

The altimetric quality and the along-track spatial resolution are the critical parameters to characterize the performance of interferometric global navigation satellite systems reflectometry (iGNSS-R) sea surface altimetry, which is closely related to each other through signal processing time. Among them, the quality of sea surface height (SSH) measurement includes precision and accuracy. In order to obtain higher altimetric quality in the observation area, a longer signal processing time is needed, which will lead to the loss of spatial resolution along the track. In contrast, higher along-track spatial resolution requires more intensive sampling, leading to unsatisfactory altimetric quality. In this study, taking the airborne iGNSS-R observation data as an example, the relationship between the altimetric quality and the along-track spatial resolution is analyzed from the perspectives of precision and accuracy. The results indicate that the reduction in the along-track spatial resolution will improve the altimetric quality. The accuracy range is 0.28–0.73 m, and the precision range is 0.24–0.65 m. However, this change is not linear, and the degree of altimetric quality improvement will decrease as the along-track spatial resolution worsens. The research results in this paper can provide a scientific reference for the configuration of parameters for future spaceborne iGNSS-R altimetry missions.
Geochemical and Mineralogical Characteristics of Garnierite From the Morowali Ni-Laterite Deposit in Sulawesi, Indonesia
Authors: Choi Yuri , Lee Insung , Moon Inkyeong 
Published: November 2021

The Morowali Ni-laterite deposit is located in the East Sulawesi Ophiolite, which is a large ophiolite belt on Sulawesi Island, Indonesia. The Morowali deposit is developed on a laterite profile due to ophiolite weathering, with saprolite, limonite, and ferruginous cap horizons from the bottom to top. Based on the occurrence of garnierite as the main ore, occurring in the saprolite horizon, it can be classified that the ore deposit is hydrous Mg silicate-type. The Ni ore is classified into different types based on color and XRD and electron probe micro-analyzer analyses. Whole-rock geochemical study was also conducted to understand the mineralization process. The Morowali Ni deposit consists of serpentine-like and talc-like phases. The serpentine-like phase consists of Ni-lizardite and karpinskite (0.76–38.26 wt% NiO) while the talc-like phase is mainly composed of kerolite (4.02–8.02 wt% NiO). The serpentine-like garnierite exhibits high Ni and Fe contents and occurrence similar to that of the serpentine observed in the saprolite horizon, suggesting the serpentine-like garnierite originated from the bedrock, and Mg-Ni cation exchange occurred during laterization. Contrastingly, the lower Fe content of the talc-like phase (0.01–0.05 wt%) than the serpentine-like phase (0.14–7.03 wt%) indicates that the talc-like garnierite is of secondary origin since Fe is immobile during weathering. The Morowali Ni-laterite deposit was mainly formed during laterization. The repetition of dry and wet cycles in each year results in the formation of secondary garnierite.
Porosity Evolution In Lacustrine Organic-Matter-Rich Shales With High Claly Minerals Content
Authors: Jiang Xiaohua , Wu Songtao , Hou Lianhua , Zhang Jinyou , Guan Modi , Zhai Fulin , Guo Jinhao , Su Ling , Liao Fengrong , Ding Lihua 
Published: November 2021

Pore structure is a major factor affecting the storage space and oil-bearing properties of shales. Mineralogy, organic matter content, and thermal evolution complicate the pore structures of lacustrine shales. In this study, the porosity evolution of organic-matter-rich shales from the Cretaceous Nenjiang Formation in the Songliao Basin, Northeast China, are investigated using thermal simulation experiments and in-situ scanning electron microscope analysis. Three findings were obtained as follows: 1) The pore system of shales from the Nenjiang Formation is dominated by inter-granular dissolution pores of plagioclase and intra-granular pores of illite-smectite mixed layers. Few organic-matter pores are observed. 2) New pores developing during thermal evolution are primarily organic matter pores and clay mineral pores, with diameters greater than 18 nm. Clay mineral pores with diameters of 18–50 nm are the principal contributors to porosity at temperatures between the low maturity stage and the oil-generation window, and organic matter pores with diameters of greater than 50 nm comprise the majority of pores generated between the gas-generation window and the high-/over-mature stages. 3) Porosity increases continuously with maturity, and the pore system varies at different maturity stages. Porosity evolution is controlled by illite content and organic matter abundance. Total pore volume correlates positively with illite content but negatively with organic matter abundance. These findings could provide guidance on shale oil evaluation in the Songliao Basin and assist in the ‘sweet-spotting’ of lacustrine shale systems across China.
Characterization of Physical Field and Flow Assurance Risk Analysis of Subsea Cage-Sleeve Throttling Valve
Authors: Jiang Donglei , Meng Wenbo , Huang Yi , Yu Yi , Zhou Youwei , Jiang Zhichen , Gao Yonghai 
Published: December 2021

The subsea production system is presently widely adopted in deepwater oil and gas development. The throttling valve is the key piece of equipment of the subsea production system, controlling the safety of oil and gas production. There are many valves with serious throttling effect in the subsea X-tree, so the hydrate formation risk is relatively high. In this work, a 3D cage-sleeve throttling valve model was established by the numerical simulation method. The temperature and pressure field of the subsea throttling valve was accurately characterized under different prefilling pressure, throttling valve opening degree, and fluid production. During the well startup period, the temperature of the subsea pipeline is low. If the pressure difference between the two ends of the pipeline is large, the throttling effect is obvious, and low temperature will lead to hydrate formation and affect the choice of throttling valve material. Based on the analysis of simulation results, this study recommends that the prefilling pressure of the subsea pipe is 7–8 MPa, which can effectively reduce the influence of the throttling effect so that the downstream temperature can be kept above 0°C. At the same time, in regular production, a suitable choke size is opened to match the production, preventing the serious throttling effect from a small choke size. According to the API temperature rating table, the negative impact of local low temperature caused by the throttling effect on the temperature resistance of the pipe was considered, and the appropriate subsea X-tree manifold material was selected to ensure production safety. The hydrate phase equilibrium curve is used to estimate the hydrate formation risk under thermodynamic conditions. Hydrate inhibitors are injected to ensure downstream flow safety.
Varied Relationship of Lipid and Lipoprotein Profiles to Liver Fat Content in Phenotypes of Metabolic Associated Fatty Liver Disease
Authors: Wu Tingfeng , Ye Junzhao , Shao Congxiang , Li Fuxi , Lin Yansong , Ma Qianqian , Wang Wei , Feng Shiting , Zhong Bihui 
Published: December 2021

BackgroundProgressive overloads of intrahepatic triglycerides are related to metabolic dysregulation of multiple lipid and lipoprotein profiles, but whether similar dose effects are found in each subtype of metabolic associated fatty liver disease (MAFLD) remains unclear. We aimed to characterize the lipid profiles associated with liver fat content (LFC) in MAFLD patients who were overweight, lean/normal weight, or had diabetes.MethodsWe conducted a cross-sectional study enrolling 1,182 consecutive participants (144 non-MAFLD and 1,038 MAFLD) who underwent MRI proton density fat fraction measurement (MRI-PDFF) from 2011 to 2020. Lipid and apolipoprotein profiles, free fatty acid (FFA), liver and metabolism parameters, and anthropometric measurements were also assessed.ResultsMAFLD patients with type 2 diabetes or overweight/obesity had a higher proportion of abnormal lipid and lipoprotein profiles than those who were lean/normal weight. The degree of LFC had a positive correlation with total cholesterol, triglyceride, ApoB, and ApoE in patients with overweight/obesity and type 2 diabetes. In those with overweight/obesity, there were dose–response relationships between moderate-to-severe steatosis and total cholesterol, triglyceride, HDL-c, LDL-c, ApoB, ApoE, and Lp(a). A similar trend was observed for triglyceride in those with type 2 diabetes and for HDL-c in patients who were lean/normal weight (all p for trend &lt;0.05). The combined model of relative lipid-related markers performed well in the prediction of moderate-to-severe steatosis (AUC: 0.762 for overweight/obesity; 0.742 for lean/normal weight).ConclusionLFC was associated with lipid profiles, including triglyceride, LDL-c, ApoB, ApoE, and FFA. These relationships were varied by the phenotype of MAFLD according to its diagnostic flow.