bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing the risk of bleeding after myomectomy: is preemptive embolization a valuable tool?
Authors: Abrahami Ylann , Najid Sophia , Petit Arthur , Sauvanet Eric , Novelli Luigi 
Published: May 2021

Abstract
Purpose
Abdominal myomectomy can be a challenging procedure, with elevated intraoperative blood loss and post-operative complications such as the need for blood transfusion and hemostasis with sometimes hysterectomy. Previous studies suggested that preemptive uterine artery embolization (PUAE) might reduce intraoperative blood loss.

Materials and methods
We reviewed all cases of abdominal myomectomy in our institution between January 2016 and June 2018. Out of 119 cases, 16 patients had PUAE and 103 did not. The objective of our study was to determine whereas PUAE reduced blood loss and post-operative complication rate.

Results
In our study, there was no difference between the two groups in regard to average blood loss (128 vs 192 mL, OR 1,00 [0.99;1,01], p = 0,73), difference between pre- and post-operative hemoglobin level (− 1,15 g/dL vs − 1,32 g/dL, OR 0,91 [0.47;1,73], p = 0,79), and post-operative complications (need for transfusion, surgical revision, post-operative embolization, hysterectomy).

Conclusion
Our findings could not conclude that PUAE is effective in reducing intraoperative blood loss during abdominal myomectomy, but it should still be considered an option for patients with large or multiple myomas, with a specific situation or previously operated, who wish to preserve their uterus.
Enhancement of drought tolerance in Triticum aestivum L. seedlings using Azospirillum brasilense NO40 and Stenotrophomonas maltophilia B11
Authors: Kasim Wedad A. , Osman Mohamed E. H. , Omar Mohamed N. , Salama Samar 
Published: May 2021

Abstract
Background
The effectiveness of two PGPB; Azospirillum brasilense NO40 and Stenotrophomonas maltophilia B11 was investigated in enhancing the drought tolerance of wheat (Triticum aestivum L.) seedlings cultivar Gemiza9. The inoculated or uninoculated grains were sown in unsterilized sandy soil and watered normally untill the 8th day. Drought stress was initiated by completely withholding water for 7 days (until wilting). Samples were collected after 15 days from sowing to evaluate some growth criteria, damage and defense indicators and to analyze the roots’ protein pattern.

Results
The results showed that inoculating wheat seedlings with these strains significantly diminished the inhibitory effects of drought stress on the relative water content of roots, shoots and leaves; area of leaves; contents of pigments (chlorophyll a and b) and ascorbic acid; and on the protein patterns of roots. Moreover, the bacterial inoculation notably reduced the drought-induced damage indicated by lower leakage of electrolytes and less accumulation of Malondialdehyde and hydrogen peroxide, surprisingly with less enhanced production of proline and activities of catalase and peroxidase than their uninoculated counterparts. Under normal conditions, inoculating wheat plants with these PGPB resulted in significantly promoted growth and elevated contents of pigments and altered protein patterns of roots.

Conclusion
Overall, we can say that both Azospirillum brasilense NO40 and Stenotrophomonas maltophilia B11 were able to deactivate the growth inhibition in wheat seedlings to some extent, while maintaining a certain level of efficient protection against damage under drought stress.
An association study between FokI, BsmI, miR-146a, and miR-155 and Behcet’s disease in the Egyptian population
Authors: Emara Mohamed M. , Mahmoud Maiada M. , Saad Mohamed N. , Mabrouk Mai S. , Hamed Mohamed , Shaker Olfat G. 
Published: May 2021

Abstract
Background
Behcet’s disease (BD) is a systemic inflammatory disease of the blood vessels and affects various body parts. This study aimed to determine the association of four single-nucleotide polymorphisms (SNPs) and BD in the Egyptian population using multiple statistical models and show the resulting associations along with previous studies of different populations. Four SNPs were examined for their association with BD: two SNPs from vitamin D receptor gene (FokI and BsmI) were selected and the other two were selected from miR-146a and miR-155. These four SNPs were selected for their association and role with BD in different populations and in the immune system. A marker check was conducted using the Hardy-Weinberg equilibrium and minor allele frequency. The associations were tested using four different statistical models: multiplicative, dominant, recessive, and codominant models. All statistical models used the odd’s ratio (OR) with confidence interval (CI) of 95% to evaluate the association of each SNP.

Results
BsmI showed association using the four models, while FokI did not show any association through any model. miR-155 showed association using the multiplicative and recessive models. miR-146a showed association using the multiplicative model only.

Conclusions
As a result, BsmI, miR-155, and miR-146a SNPs could have a role in the development of BD in the Egyptian population, while FokI could have a weak role, if any, in the development of BD in the Egyptian population.
A mixed methods evaluation of the large-scale implementation of a school- and community-based parenting program to reduce violence against children in Tanzania: a study protocol
Authors: Martin Mackenzie , Lachman Jamie , Wamoyi Joyce , Shenderovich Yulia , Wambura Mwita , Mgunga Samwel , Ndyetabura Esther , Ally Amal , Barankena Asheri , Exavery Amon , Manjengenja Nyasha 
Published: May 2021

Abstract
Background
Despite the rapid dissemination of parenting programs aiming to reduce and prevent violence against children (VAC) worldwide, there is limited knowledge about and evidence of the implementation of these programs at scale. This study addresses this gap by assessing the quality of delivery and impact of an evidence-based parenting program for parents/caregivers and their adolescent girls aged 9 to 14—Parenting for Lifelong Health Teens (PLH-Teens), known locally as Furaha Teens—on reducing VAC at scale in Tanzania. The study will explore participating family and staff perspectives on program implementation and examine factors associated with implementation and how implementation quality is associated with intervention outcomes when the program is delivered to approximately 50,000 parent-child dyads (N = 100,000) in schools and community centers across eight districts of Tanzania.

Methods
This mixed-methods study will answer the following research questions: (1) what is the implementation quality and fidelity of PLH-Teens at scale in Tanzania; (2) what factors are associated with the quality of delivery and implementation fidelity of PLH-Teens; (3) how are implementation quality and fidelity associated with intervention outcomes; (4) what are participant and implementing staff perspectives on the acceptability, appropriateness, feasibility, benefits, and challenges of delivering PLH-Teens in their schools and communities; (5) what is the impact of PLH-Teens on VAC and participant well-being; and (6) how much does it cost to deliver PLH-Teens at scale? Qualitative and quantitative data will be collected directly from implementers, parents/caregivers, and adolescents using pre-post questionnaires, observational assessments, cost surveys, focus groups, and interviews. Qualitative data will be analyzed thematically with the aid of NVIVO software. Quantitative data will be cleaned and analyzed using methods such as correlation, regression, and structural equation models using Stata and R. COREQ and TREND guidelines will be used, where appropriate.

Discussion
Findings will provide vital insights into some of the factors related to quality implementation at scale. Lessons learned regarding the implementation of PLH-Teens at scale will be applied in Tanzania, and also in the delivery of PLH parenting programs globally.
The bucket test reinterpreted: a study on benign paroxysmal positional vertigo and Ménière’s disease patients
Authors: Castro-Urquizo Angel , Celis-Aguilar Erika , Rubio-Partida Guillermo Alejandro 
Published: May 2021

Abstract
Background
The bucket test is a simple and practical instrument to evaluate vestibular diseases; additionally, it could be a useful tool in the evaluation of the vertigo patient. Unfortunately, the bucket test still lacks standardization. The objective of this study was to evaluate and to interpret the subjective visual vertical (SVV) using the bucket test in benign paroxysmal positional vertigo (BPPV) and Ménière’s disease patients. We performed a cross-sectional study in a secondary care center. All patients with diagnosis of unilateral posterior canal BPPV or Ménière’s disease underwent complete neuro-otological physical examination and the bucket test. Normal bucket test was 0° to 3° according to previous study.

Results
We included seventy-eight subjects. Benign paroxysmal positional vertigo cases (n = 51) showed a mean 2.62° of SVV prior to the Epley maneuver and 1.7° of SVV after the maneuver (p = < 0.001), 57% of patients with BPPV were categorized as abnormal. Inactive Ménière’s disease patients (n = 22) had mean SVV of 2.74° and Ménière’s disease with active crisis (n = 5) had 5.06° of SVV (p = 0.002).

Conclusion
The bucket test is a simple and useful test for the evaluation of SVV, and it has a role in the evaluation of patients with active vestibular diseases such as Ménière’s disease and BPPV.
Towards estimating the economic cost of invasive alien species to African crop and livestock production
Authors: Eschen René , Beale Tim , Bonnin J. Miguel , Constantine Kate L. , Duah Solomon , Finch Elizabeth A. , Makale Fernadis , Nunda Winnie , Ogunmodede Adewale , Pratt Corin F. , Thompson Emma , Williams Frances , Witt Arne , Taylor Bryony 
Published: May 2021

Abstract
Background
Invasive alien species (IAS) cause significant economic losses in all parts of the world. Although IAS are widespread in Africa and cause serious negative impacts on livelihoods as a result of yield losses and increased labour costs associated with IAS management, few data on the impacts are available in the literature and the magnitude and extent of the costs are largely unknown. We estimated the cost of IAS to agriculture, the most important economic sector in Africa.

Methods
Data on the monetary costs of IAS to mainland Africa as well as information about the presence and abundance of the most important IAS were collected through literature review and an online survey among a wide variety of stakeholders. Using this and additional data from publicly available sources we estimated yield losses and management costs due to IAS in agriculture for individual countries and the entire continent. Where the data allowed, the costs for selected IAS or crops were estimated separately. The estimates were extrapolated using production and distribution data and/or matching of agro-ecological zones.

Results
The total estimated annual cost of IAS to agriculture in Africa is USD 65.58 Bn. Management costs (comprising mainly labour costs associated with weeding), crop yield losses and reductions in livestock derived income constitute the majority of the estimated cost (55.42, 44.31 and 0.26 percent, respectively). The IAS causing the highest yield losses was Spodoptera frugiperda (USD 9.4 Bn).

Conclusions
This study reveals the extent and scale of the economic impacts of IAS in the agricultural sector in one of the least studied continents. Although the cost estimate presented here is significant, IAS also cause major costs to other sectors which could not be assessed due to data deficit. The results highlight the need for pre-emptive management options, such as prevention and early detection and rapid response to reduce huge potential future costs, as well as measures that contribute to large-scale control of widely established IAS at little cost to farmers and other affected land users, to reduce losses and improve livelihoods.
Phase II Single-Arm Study to Assess Trastuzumab and Vinorelbine in Advanced Breast Cancer Patients With HER2-Negative Tumors and HER2-Positive Circulating Tumor Cells
Authors: Parsons Heather A. , Macrae Erin R. , Guo Hao , Li Tianyu , Barry William T. , Tayob Nabihah , Wulf Gerburg M. , Isakoff Steven J. , Krop Ian E. 
Published: May 2021

PURPOSEHuman epidermal growth factor receptor 2 (HER2)–directed treatments improve outcomes for patients with HER2-positive metastatic breast cancer (MBC). Current identification of patients with HER2-positive disease relies on tumor tissue testing, which can be inaccurate because of tumor heterogeneity or tumor evolution. Circulating tumor cells (CTCs) are often present in patients with cancer. We hypothesized that HER2 assessment of CTCs in patients with HER2-negative breast cancer could identify a subset of patients with HER2-positive CTCs who could benefit from HER2-directed treatments.METHODSThis was a single-arm, two-stage, phase II trial. Patients with HER2-negative progressive MBC with HER2-positive CTC (defined as HER2/CEP17 ratio ≥ 2.0 by fluorescence in situ hybridization), ≥ 1 prior chemotherapy regimen for MBC, and no prior vinorelbine received trastuzumab in combination with vinorelbine on days 1, 8, and 15 of a 21-day cycle. The primary end point was objective response rate.RESULTSFrom January 2013 to June 2014, we prospectively screened CTCs from patients with HER2-negative MBC. CTCs were detected in 201 of 311 patients (65%). The median number of CTCs was 10 (interquartile range, 3-57). Sixty-nine of 311 patients (22%) had HER2+ CTCs, with a median of three HER2+ CTCs (range 1-21). Twenty patients with HER2+ CTCs were treated on study. At data cutoff (January 13, 2017), no patients remained on study therapy. The objective response rate was 5% (95% CI, 0.1 to 24.9), with one of 20 patients experiencing a partial response. The clinical benefit rate was 20.0% (1 partial response and 3 stable diseases > 24 weeks, 95% CI, 5.7% to 43.7%). The median progression-free survival was 2.7 months.CONCLUSIONCTC analysis of patients with HER2-negative MBC identifies a subset with HER2-amplified CTCs. However, clinical activity of an HER2-directed regimen in this population was low. The functional significance of HER2-positive CTCs remains uncertain.
Drawing the Line on Oil inPetrochemical America
Authors: Houser Heather 
Published: May 2021

AbstractPetrochemical America, an art book and atlas cocreated by photographer Richard Misrach and landscape architect Kate Orff, is a rejoinder to commonplaces about oil’s invisibility and evasion of representation. The book’s visualizations produce a narrative atlas that depicts the oil industry’s transformations of US landscapes and communities. Central to this depiction is Orff’s use of the line, a form essential to visualization technique. Orff’s lines go deep rather than “look across” surfaces to tell stories of growth, fragmentation, toxicity, and displacement. Detailing the affordances of the line as a tool of atlas making and mapmaking, this article argues that Petrochemical America employs lines in ways that stage the oppositional logics at the heart of the petrochemical industry, that is, its tactical recruitment of vertical and horizontal, natural and human made, visible and invisible, proximity and dispersal, and containment and contamination. Without purporting to expose the hidden and without reproducing deterministic narratives of petrochemical dominance, Orff promotes ways of apprehending oil’s pasts, presents, and futures.
Bird Banding and the Environmental Humanities
Authors: Whitney Kristoffer 
Published: May 2021

AbstractThis article tells a history of bird banding—the practice of catching and affixing birds with durable bands with the intent of tracking their movements and behavior—by focusing on the embodied aspects of this method in field ornithology. Going beyond a straightforward, institutional history of bird banding, the article uses the writings of biologists in the US Bureau of Biological Survey and the US Fish and Wildlife Service to describe the historical practices of bird banding and the phenomenological experience of banding, both for the scientists and the birds (via their banding interlocutors). The article then presents the career and research of Margaret Morse Nice as an exemplar of the embodied practice of banding for the purposes of understanding bird behavior. Finally the article uses the example and heritage of Nice as well as banders and scientists like her to discuss a phenomenological approach common to any number of observation-based field biology disciplines (including, especially, ethology) and deep connections between human and animal subjectivities. And these connections, in turn, have implications for the environmental humanities, environmental conservation, and the ethics of knowing the nonhuman world.
Art for a Future Planet
Authors: Page Joanna 
Published: May 2021

AbstractJoanna Zylinska proposes a “feminist counterapocalypse,” which would resist the anthropocentric, technicist perspectives that shape apocalyptic narratives of climate crisis. Like Anna Tsing’s exploration of collaborative survival, Zylinska’s counterapocalypse is founded on the notion of precarity as a shared condition of life in the postindustrial world. This article focuses on art-science projects by Joaquín Fargas (Argentina) and Paul Rosero Contreras (Ecuador) that imagine environmental futures. In contrasting their projects the author asks how they endorse or subvert the anthropocentrism that often motivates the representation of climate change as reversible (humans save the planet) or, indeed, as irreversible (humans destroy the planet). Drawing on the work of Andreas Weber and several Latin American scholars, including Eduardo Gudynas and Raquel Gutiérrez Aguilar, the author suggests ways in which biosemiotic and biocentric perspectives may make a valuable contribution to the counterapocalypse Zylinska proposes. The analysis of Rosero’s work in particular opens up ways in which one might consider other paradigms rather than precarity as the basis for a postanthropocentric counterapocalypse, including abundance, reciprocity, collaboration, and coevolution. These are found everywhere in complex ecosystems and relate closely to the principles on which theories and practices of the commons are founded, both in Latin America and beyond.
Species Suicide Notes
Authors: Cardon Kristen 
Published: May 2021

AbstractThis article tracks the history of species suicide, a phrase that originally referred to a potential nuclear holocaust but is now increasingly cited in Anthropocene discourses to account for continued carbon emissions in the face of catastrophic climate change. With its Anglophone roots in the Cold War, species suicide discourse unites concerns about nuclear arsenals, so-called overpopulation, and environmental injustice across disciplines. Species suicide discourse is indebted to the US-based field of suicide prevention, which for more than half a century has analyzed suicide notes in search of effective prevention methods. Therefore, to theorize suicide prevention in relation to anthropogenic climate change, this article imagines a version of this genre that mediates between individual and collective subjects—called a species suicide note. As an example, the interdisciplinary and multimedia art project “Dear Climate” (2012–ongoing) by Una Chaudhuri, Oliver Kellhammer, and Marina Zurkow rewrites familiar narratives of crisis, shifting species suicide notes toward irony and unconventional techniques of hope. In analyzing these performative species suicide notes, the author complicates species suicide prevention by foregrounding narratives of irony. These notes accentuate a self-reflexive irony that works toward climate justice for vulnerable humans and more-than-human species.
A nematode-derived, mitochondrial stress signaling-regulated peptide exhibits broad antibacterial activity
Authors: Sapkota Madhab , Adnan Qureshi Mohammed , Arif Mahmud Siraje , Balikosa Yves , Nguyen Charlton , Boll Joseph M. , Pellegrino Mark W. 
Published: May 2021

ABSTRACT
A dramatic rise of infections with antibiotic-resistant bacterial pathogens continues to challenge the healthcare field due to the lack of effective treatment regimes. As such, there is an urgent need to develop new antimicrobial agents that can combat these multidrug-resistant superbugs. Mitochondria are central regulators of metabolism and other cellular functions, including the regulation of innate immunity pathways involved in the defense against infection. The mitochondrial unfolded protein response (UPRmt) is a stress-activated pathway that mitigates mitochondrial dysfunction through the regulation of genes that promote recovery of the organelle. In the model organism Caenorhabditis elegans, the UPRmt also mediates an antibacterial defense program that combats pathogen infection, which promotes host survival. We sought to identify and characterize antimicrobial effectors that are regulated during the UPRmt. From our search, we discovered that the antimicrobial peptide CNC-4 is upregulated during this stress response. CNC-4 belongs to the caenacin family of antimicrobial peptides, which are predominantly found in nematodes and are known to have anti-fungal properties. Here, we find that CNC-4 also possesses potent antimicrobial activity against a spectrum of bacterial species and report on its characterization.
Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity
Authors: Kaufman Michael L. , Goodson Noah B. , Park Ko Uoon , Schwanke Michael , Office Emma , Schneider Sophia R. , Abraham Joy , Hensley Austin , Jones Kenneth L. , Brzezinski Joseph A. 
Published: May 2021

ABSTRACT
During retinal development, a large subset of progenitors upregulates the transcription factor Otx2, which is required for photoreceptor and bipolar cell formation. How these retinal progenitor cells initially activate Otx2 expression is unclear. To address this, we investigated the cis-regulatory network that controls Otx2 expression in mice. We identified a minimal enhancer element, DHS-4D, that drove expression in newly formed OTX2+ cells. CRISPR/Cas9-mediated deletion of DHS-4D reduced OTX2 expression, but this effect was diminished in postnatal development. Systematic mutagenesis of the enhancer revealed that three basic helix-loop-helix (bHLH) transcription factor-binding sites were required for its activity. Single cell RNA-sequencing of nascent Otx2+ cells identified the bHLH factors Ascl1 and Neurog2 as candidate regulators. CRISPR/Cas9 targeting of these factors showed that only the simultaneous loss of Ascl1 and Neurog2 prevented OTX2 expression. Our findings suggest that Ascl1 and Neurog2 act either redundantly or in a compensatory fashion to activate the DHS-4D enhancer and Otx2 expression. We observed redundancy or compensation at both the transcriptional and enhancer utilization levels, suggesting that the mechanisms governing Otx2 regulation in the retina are flexible and robust.