bluuebunny/crossref_metadata_2025_split huggingface dataset:
More trust in networks, more secure keys
Authors: Fan-Yuan Guan-Jie , Wang Shuang 
Published: January 2025

AbstractA novel continuous-variable quantum passive optical network is proposed in which a user can increase their key rate by trusting other users. This is because the keys, which would be discarded to remove correlations with untrusted users, can be retained when the users are trusted. It provides a new perspective for enhancing network performance.
Skeletal interoception and prospective application in biomaterials for bone regeneration
Authors: Bai Long , Li Jilong , Li Guangfeng , Zhou Dongyang , Su Jiacan , Liu Changsheng 
Published: January 2025

AbstractAccumulating research has shed light on the significance of skeletal interoception, in maintaining physiological and metabolic homeostasis related to bone health. This review provides a comprehensive analysis of how skeletal interoception influences bone homeostasis, delving into the complex interplay between the nervous system and skeletal system. One key focus of the review is the role of various factors such as prostaglandin E2 (PGE2) in skeletal health via skeletal interoception. It explores how nerves innervating the bone tissue communicate with the central nervous system to regulate bone remodeling, a process critical for maintaining bone strength and integrity. Additionally, the review highlights the advancements in biomaterials designed to utilize skeletal interoception for enhancing bone regeneration and treatment of bone disorders. These biomaterials, tailored to interact with the body’s interoceptive pathways, are positioned at the forefront of innovative treatments for conditions like osteoporosis and fractures. They represent a convergence of bioengineering, neuroscience, and orthopedics, aiming to create more efficient and targeted therapies for bone-related disorders. In conclusion, the review underscores the importance of skeletal interoception in physiological regulation and its potential in developing more effective therapies for bone regeneration. It emphasizes the need for further research to fully understand the mechanisms of skeletal interoception and to harness its therapeutic potential fully.
Pivotal roles of biglycan and decorin in regulating bone mass, water retention, and bone toughness
Authors: Hua Rui , Han Yan , Ni Qingwen , Fajardo Roberto J. , Iozzo Renato V. , Ahmed Rafay , Nyman Jeffry S. , Wang Xiaodu , Jiang Jean X. 
Published: January 2025

AbstractProteoglycans, key components of non-collagenous proteins in the bone matrix, attract water through their negatively charged glycosaminoglycan chains. Among these proteoglycans, biglycan (Bgn) and decorin (Dcn) are major subtypes, yet their distinct roles in bone remain largely elusive. In this study, we utilized single knockout (KO) mouse models and successfully generated double KO (dKO) models despite challenges with low yield. Bgn deficiency, but not Dcn deficiency, decreased trabecular bone mass, with more pronounced bone loss in dKO mice. Low-field nuclear magnetic resonance measurements showed a marked decrease in bound water among all KO groups, especially in Bgn KO and dKO mice. Moreover, both Bgn KO and dKO mice exhibited reduced fracture toughness compared to Dcn KO mice. Dcn was significantly upregulated in Bgn KO mice, while a modest upregulation of Bgn was observed in Dcn KO mice, indicating Bgn’s predominant role in bone. High resolution atomic force microscopy showed decreased in situ permanent energy dissipation and increased elastic modulus in the extrafibrillar matrix of Bgn/Dcn deficient mice, which were diminished upon dehydration. Furthermore, we found that both Bgn and Dcn are indispensable for the activation of ERK and p38 MAPK signaling pathways. Collectively, our results highlight the distinct and indispensable roles of Bgn and Dcn in maintaining bone structure, water retention, and bulk/in situ tissue properties in the bone matrix, with Bgn exerting a predominant influence.
LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer
Authors: Li Fei , Dai Pengfei , Shi Huili , Zhang Yajuan , He Juan , Gopalan Anuradha , Li Dan , Chen Yu , Du Yarui , Xu Guoliang , Yang Weiwei , Liang Chao , Gao Dong 
Published: January 2025

AbstractEpigenetic regulation profoundly influences the fate of cancer cells and their capacity to switch between lineages by modulating essential gene expression, thereby shaping tumor heterogeneity and therapy response. In castration-resistant prostate cancer (CRPC), the intricacies behind androgen receptor (AR)-independent lineage plasticity remain unclear, leading to a scarcity of effective clinical treatments. Utilizing single-cell RNA sequencing on both human and mouse prostate cancer samples, combined with whole-genome bisulfite sequencing and multiple genetically engineered mouse models, we investigated the molecular mechanism of AR-independent lineage plasticity and uncovered a potential therapeutic strategy. Single-cell transcriptomic profiling of human prostate cancers, both pre- and post-androgen deprivation therapy, revealed an association between liver kinase B1 (LKB1) pathway inactivation and AR independence. LKB1 inactivation led to AR-independent lineage plasticity and global DNA hypomethylation during prostate cancer progression. Importantly, the pharmacological inhibition of TET enzymes and supplementation with S-adenosyl methionine were found to effectively suppress AR-independent prostate cancer growth. These insights shed light on the mechanism driving AR-independent lineage plasticity and propose a potential therapeutic strategy by targeting DNA hypomethylation in AR-independent CRPC.
Different technology packages for aluminium smelters worldwide to deliver the 1.5 °C target
Authors: Tan Chang , Yu Xiang , Li Dan , Lei Tianyang , Hao Qi , Guan Dabo 
Published: January 2025

AbstractProduction of aluminium, one of the most energy-intensive metals, is challenging for mitigation efforts. Regional mitigation strategies often neglect the emissions patterns of individual smelters and fail to guide aluminium producers’ efforts to reduce GHG emissions. Here we build a global aluminium GHG emissions inventory (CEADs-AGE), which includes 249 aluminium smelters, representing 98% of global primary aluminium production and 280 associated fossil fuel-based captive power units. We find, despite the installation of more efficient and higher amperage cells, that the share of aluminium production powered by fossil fuel-based captive power units increased from 37% to 49% between 2012 and 2021. Retiring fossil fuel-based captive power plants 10 years ahead of schedule could reduce emissions intensity by 5.0–10.5 tCO2e per tonne of aluminium for dependent smelters. At least 18% of smelting capacity by 2040 and 67% by 2050 must be retrofitted with inert anode technology to achieve net-zero targets.
Hybrid spatial and channel attention in post‐accident object detection
Authors: Kim Junyoung , Lee Soomok 
Published: January 2025

AbstractAnalysing post‐accident scenes using in‐vehicle cameras is crucial for effective highway traffic control and enhancing accident response, road safety, and traffic flow. This contributes to a comprehensive understanding of the situation and achieves better decision‐making and effective management. The accident scene report system is designed to focus on specific post‐accident objects, such as crashed vehicles, involved individuals, emergency vehicles, and debris. This means that the post‐accident object detection algorithm needs to handle a wide variety of objects, from large collapsed vehicles to tiny particles. It should operate in real‐time on embedded boards, balancing detection accuracy and compactness to fit within the constraints of embedded computing modules. This approach aims to facilitate prompt reporting to traffic control centres. In this study, a hybrid spatial and channel attention and its pruning algorithm tailored for object detection in post‐accident scenarios are proposed. This approach markedly enhances the detection performance in the unexpected accidents and malfunctioning scenes, significantly boosting the system's accuracy and processing speed. The method optimally balances the model compactness with seamless attention and pruning, making it highly suitable for real‐time applications in traffic monitoring systems. The proposed seamless attention and pruning method is demonstrated using the proposed accident object detection dataset.
Gedanken zur Behandlung von Cochlea-Implantat-Trägern
Authors: Huss Simone 
Published: January 2025

ZusammenfassungDie Entscheidung für ein Cochlea-Implantat fällt in Abhängigkeit des Ausmaßes der
Hörminderung und nach eingehender Beratung und Diagnostik. In jedem Fall kann
man bezüglich der osteopathischen Gedanken von einer strukturellen Veränderung
(Hörminderung) als Ursache der individuellen Symptomatik von
Cochlea-Implantat-Trägern ausgehen. Dies macht eine regelmäßige osteopathische
Behandlung zur Unterstützung des gesamten Systems und der Förderung der
Autoregulation notwendig.
Peripartum and Perinatal Outcomes in Pregnant Women with Elevated Preconceptional Body Mass Index in a Maternity Hospital (Care Level IV)
Authors: Dammer Ulf , Gall Christine , Pretscher Jutta , Schneider Michael O. , Faschingbauer Florian , Loehberg Christian R. , Beckmann Matthias W. , Kehl Sven 
Published: January 2025

AbstractPreconception obesity is a risk factor for pregnancy and delivery, which is why giving birth in a perinatal center (care levels I and II) is recommended. There are currently no studies which have investigated the birth outcomes of obese patients based on the care level of the maternity hospital. This study aims to assess the effect of a higher body mass index prior to conception on maternal and fetal outcomes in a maternity hospital (care level IV).A total of 5616 pregnant women who gave birth between 2016 and 2023 were investigated in this retrospective cohort study, after taking the inclusion and exclusion criteria into account. Primary outcome parameter of this study was the transfer of the neonate to a neonatal intensive care unit. Other target parameters were the need to induce labor, delivery mode, Apgar score and pH value, and the incidence of complications (shoulder dystocia, higher-degree perineal tears, or peripartum hemorrhage).Overweight and obesity were associated with a higher rate of hypertensive disorders of pregnancy and gestational diabetes and were accompanied by higher rates of induction of labor and elective and secondary caesarean sections. Maternal outcome parameters such as intrapartum fever, preterm placental abruption, uterine rupture, higher-degree birth injuries and peripartum hemorrhage did not occur significantly more often in obese pregnant women. Fetal outcome parameters such as Apgar score and pH value did not differ from those reported for normal-weight pregnant women. Multivariate regression analysis showed a high risk of transfer to a neonatal intensive care unit (OR = 1.97; p = 0.035) for neonates born to women in obesity class II (BMI 35–39.9 kg/m2), women with gestational diabetes (OR = 1.71; p = 0.033), and nulliparous women (OR = 1.59; p = 0.005).Obesity class II is associated with a slightly higher risk of transfer of the neonate to a pediatric intensive care unit but is not associated with worse Apgar scores or pH values. Pregnant women with a body mass index between 35 and 40 kg/m2 should be informed of this and should consider giving birth in a facility with a neonatal department (care level I–III).
Synthesis of Monofluoroalkene-Based Dipeptide Bioisosteres via Regioselective Ring Opening of 1,1-Difluorocyclopropanes
Authors: Fuchibe Kohei , Mitsumori Masashi , Ishikawa Kai , Ichikawa Junji 
Published: January 2025

AbstractMonofluoroalkene-based dipeptide bioisosteres were synthesized via (I) difluorocyclopropane ring opening and (II) SN2′-type defluorination. (2,2-Difluorocyclopropyl)methyl acetates were treated with acetonitrile in the presence of trifluoromethanesulfonic acid (triflic acid, TfOH). Elimination of acetic acid resulted in regioselective cleavage of the C–C bond distal to the CF2 moiety (ring opening), and then a Ritter-type N-terminal introduction afforded N-(2,2-difluorohomoallyl)acetamides. The obtained difluoroacetamides underwent allylic substitution of bromine for fluorine in an AlBr3/CuBr system to generate 3-fluoroallylic bromides, whose substitution with n-Bu4NCN facilitated C-terminal introduction. Conversion of the cyano group into a carbamoyl group afforded the desired monofluoroalkene-based dipeptide bioisosteres.
Development of a 300 kV/3 kHz nanosecond pulse generator using semiconductor opening switches
Authors: Chen Yu-hao , Yang Jie , Xie Yan-Zhao 
Published: January 2025

In this paper, we present the development of a nanosecond pulse generator utilizing semiconductor opening switches (SOS), designed to deliver high voltage and operate at a high repetitive frequency. The pulse generator comprises three main components: a primary charging unit, a magnetic pulse compression unit, and an SOS magnification unit. To ensure stable operation of the high-power charging unit at high repetitive frequencies, a rectifying resonant charging and energy recovery circuit are implemented, providing a 1 kV charging voltage at a 3 kHz repetition rate. The three-stage magnetic pulse compression is designed to reduce the pulse width from tens of microseconds to tens of nanoseconds, where self-demagnetization could be completed during repetitive frequency operation. To achieve an output voltage of 300 kV, multiple SOS switches are employed in a series. The developed pulse generator achieves a final output of 300 kV with a 3 kHz repetitive frequency under a load of 2 kΩ. Furthermore, the effects of multiple factors on the output performance are characterized by both simulation and measurement for a comprehensive analysis.
Structural, dielectric and magnetic properties of Sb/Cr-doped CaCu3Ti4O12 quadruple perovskite oxides
Authors: Ding Jie , Zhu Xinhua 
Published: January 2025

Abstract
Driven by the miniaturization of microelectronic devices and their multifunctionalities, the development of new quadruple-perovskite oxides with high dielectric constants and high Curie temperature are highly required. Herein, we report on the structural, dielectric and magnetic properties of Sb/Cr-doped CaCu3Ti4O12 (CCTO) quadruple perovskite oxides, CaCu3Ti3.9Sb0.1O12 (CCTSO) and CaCu3Ti3CrO12 (CCTCO). Structural Rietveld refinements demonstrated that the CCTO, CCTSO, and CCTCO ceramics adopted a cubic crystal structure (Im

3
¯

space group). They exhibited spherical shapes with nearly uniform particle sizes. XPS spectra clarified Cu3+ ions in the CCTSO ceramics, while Cu2+ and Cu+ ions, and Cr3+ ions in the CCTCO ceramics. All the ceramic samples displayed nearly frequency independent dielectric behaviors at low temperatures but a relaxor dielectric behavior at high temperatures. Such relaxor dielectric behavior in the CCTO and CCTSO ceramics was ascribed to the movement of doubly ionized oxygen vacancies but in the CCTCO ceramics to the movement of singly ionized oxygen vacancies. Impedance and modulus spectra reveal the significance contributions of grains and grain boundaries with non-Debye behavior. At room temperature (RT) the dielectric constant (ϵ
r) and dielectric loss (tanδ) of CCTO ceramics at 1 kHz were 15 922 and 0.126, respectively. An order reduction of tanδ was achieved in the CCTSO ceramics. In the CCTCO ceramics, the ϵ
r and tanδ at RT and 1 kHz were 975 and 0.453, respectively. The CCTCO powders exhibited antiferroelectric behavior at 2 K with a saturation magnetization (M
S) of 1.42 μ
B/f.u., while the M
S for the CCTSO powders was only 0.027 μ
B/f.u. All ceramic samples exhibited semiconductor characteristics owing to their continuous decreases of resistivity from 2 K to 800 K. Our present work demonstrates an effective route to tuning the dielectric and magnetic properties of CCTO oxides via B-site non-magnetic/magnetic ion-doping.
A laser tracking attitude dynamic measurement method based on real-time calibration and AEKF with a multi-factor influence analysis model
Authors: Xiong Zhi , Dong Jiale , Guo Zhengnan , Jia Xiaodong , Zhai Zhongsheng , Zhao Ziyue , Dong Dengfeng , Zhou Weihu 
Published: January 2025

Abstract
To address the limitations of six-degree-of-freedom (6-DOF) visual tracking systems in terms of low dynamic performance and the inability to perform measurements under light occlusion, this paper proposes a novel laser tracking attitude dynamic measurement method integrating vision and inertial measurement unit (IMU). A tailored real-time calibration model is developed to enable precise alignment of the vision and IMU coordinate systems during dynamic operations. To overcome the limitations of extended Kalman filter (EKF) that rely on static noise assumptions in complex dynamic measurement scenarios, this study proposes an adaptive mechanism based on multi-factor influence analysis. Through dynamic monitoring of visual observation noise, an adaptive EKF algorithm is designed to enhance performance under varying conditions. When integrated into a vision/IMU fusion system, the algorithm significantly enhances the system’s sensitivity to variations in visual sensor observation noise caused by changes in lighting and motion states. This capability allows rapid adjustment of filtering parameters, leading to substantial improvements in filtering accuracy and stability. Simulation results demonstrate that the proposed algorithm outperforms traditional EKF in fusion measurement accuracy when tested in simulated noise environments featuring sinusoidal and random jump signals. Furthermore, the fusion measurement accuracy is mainly influenced by the data density of the visual sensor and the measurement distance. Finally, the proposed method was validated on a precision turntable. Experimental results reveal that at a 3 m measurement distance and within a 0°–25° angular range, when the turntable rotates at a constant speed of 5°/s along a single axis, the maximum absolute deviation in repeatability of the fused attitude measurements was below 0.11°, and the system is capable of achieving a high measurement frequency of 100 Hz.
Analysis and assessment of multi-GNSS inter-system bias (ISB) and its benefit on real-time precise point positioning
Authors: Yang Yuze , Jiao Guoqiang , Su Ke 
Published: January 2025

Abstract
To meet the high demand for convergence speed in real-time precise point positioning (RTPPP), this paper comprehensively considers both satellite clock offset services and the PPP user perspective, deriving the inter-system bias (ISB) in detail. Using the precise satellite clock offset products from Wuhan University along with self-computed products, we analyze the datum issues related to satellite clock offsets/ISB, taking into account the effects of daily boundary changes, and propose a reliable ISB product workflow. We examine the statistical characteristics of ISB for different receiver types, highlighting their potential to enhance RTPPP performance as prior constraints. Experimental results indicate that after datum unification, the discontinuity of ISB caused by daily boundary issues can be avoided; the ISB values for the same type of receivers are closely aligned, and the statistical characteristics of ISB remain stable. When utilizing ISB products as prior constraints in the Global Positioning System + BeiDou Navigation Satellite System dual-system RTPPP, the root mean square and convergence time in the East-Up-North direction improve by 18%, 10%, 2%, 8%, 3%, and 1% compared to the original PPP, respectively. For the Global Positioning System + Galileo navigation satellite system, the corresponding improvements are 28%, 26%, 17%, 39%, 31%, and 17%.
Percolation theory-based KMC simulation for scaled Fe-FET based multi-bit computing-in-memory with temperature compensation strategy
Authors: Zhu Qingxiao , Xu Lihua , Zhou Zhidao , Wei Wei , Xv Pan , Dou Chunmeng , Wang Lingfei , Luo Qing , Li Ling 
Published: January 2025

Abstract
In this letter, we investigate the impact of percolation transport mechanisms on ferroelectric field effect transistor (FeFET) multi-value storage with kinetic Monte-Carlo (KMC) simulation considering aspect ratio and temperature dependencies. It is found that the portion of the ferroelectric polarization, which dominates the threshold voltage shift of the FeFET, increases when aspect ratio of device decreases. Moreover, randomness of percolation path formation and variations of equivalent conductance can be suppressed, indicating mitigation of device-to-device variations and enhancement of separation of individual states. Besides, to further investigate an amorphous channel promising in multi-bit applications, disorder effects in channel contribute to intrinsic percolation transport, coupling with multi-domain dynamics in Fe-layer, are studied by the high temperature characterization. On this basis, the KMC scheme is further modified to predict multi-value distribution from 300 K to 400 K. To tackle such critical reliability issues induced inaccuracy for in-memory computing (CIM), an efficient write-verify scheme is proposed to mitigate state overlapping and provide in-depth insights for co-design of device reliability and multi-bit CIM performances.
Optimized design of self-powered SSHI interface circuit for enhanced vibration energy harvesting
Authors: Zhang Bin , Yang Guang , Hu Bingxin , Xiong Yeping , Zhou Shengxi 
Published: January 2025

Abstract
Vibrational energy in ambient environment can be transformed into electrical power through piezoelectric energy harvesters and using synchronized switch harvesting on inductor (SSHI) techniques can significantly improve energy extraction efficiency. To enhance energy harvesting efficiency, this study proposes an efficient self-powered parallel SSHI (ESP-PSSHI) interface circuit. It enhances the passive peak detection switch, simplifies the circuit topology, reduces switching delay, and minimizes the ‘second inversion’, contributing to increased energy harvesting efficiency. To improve the impedance-matching characteristics of the circuit, the proposed circuit is combined with a DC–DC converter module and finally, a stable electrical output is achieved. The performance of the ESP-PSSHI circuit in power generation is analyzed through simulation and subsequently verified via experimentation. Experiments show that the maximum output power of the ESP-PSSHI circuit is 2.42 and 1.16 times higher than the output power of the standard energy harvesting circuit and self-powered parallel SSHI (SP-PSSHI) circuit, respectively. Through capacitor charging experiments, it is concluded that the output power of the optimized ESP-PSSHI circuit is 1.5 times the output power of the LTC3588-1 circuit.