bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Synthesis of Aigialomycin D Analogues
Authors:   , Ting Samuel Z.Y. 
Published: November 2021

<p>Aigialomycin D is a fungal natural product possessing kinase inhibition properties. It is a member of a class of compounds known as the resorcylic acid lactones, a expansive group containing compounds exhibiting a vast array of biological activities. These include kinase and Hsp90 inhibition, highly desirable properties in the drug development field. This research project sought to capitalise on previous work involving the successful total synthesis of aigialomycin D. By developing the synthetic methodology, analogues of aigialomycin D could be prepared for biological testing to obtain valuable structure-activity relationship information. The focus of this thesis involves the successful synthesis of aigialomycin D diastereomer, 5',6'-epi,epi-aigialomycin D and the attempted synthesis of 100-epi-aigialomycin D, via the synthetic strategy developed previously in combination with enantiomeric starting material fragments ... The synthesis of functional group analogues, 6'-oxo-aigialomycin D, 7',8'-cyclopropyl aigialomycin D and 5-chloro-agialomycin D were also attempted via derivatisation of late-stage intermediates in the aigialomycin D synthesis. The thesis herein recounts the successes and failures in the synthesis of various aigialomycin D analogues ...</p>
Automatic Shear Wave Splitting Measurements at Mt. Ruapehu Volcano, New Zealand
Authors:   , Wessel Andreas 
Published: November 2021

<p>This thesis presents an automatic shear wave splitting measurement tool and the results from its application to data recorded in the vicinity of Mt. Ruapehu volcano on the North Island of New Zealand. The best methodology and parameters for routine automatic monitoring are determined and approximately 10,000 events are processed. About 50% of all S-phases lead to measurements of acceptable quality. Results obtained with this technique are reproducible and objective, but more scattered than results from manual measurements. The newly developed automatic measurement tool is used to measure shear wave splitting for previously analysed data and for new data recorded in 2003-2007. In contrast to previous studies at Mt. Ruapehu, we have a larger and continuous data set from numerous three-component seismic stations. No major temporal changes are found within the new data, but results vary for di erent station locations. I</p>
Crimes of Consumption: Polemical uses of Gluttony and Cannibalism in English Print, 1580-1625
Authors:   , Alexander Rata Lanei 
Published: November 2021

<p>Attacks on excessive consumption are an enduring theme in Western biblical and Greco- Roman thought. This dissertation attempts to unravel the cultural and political context of two such critiques. The 'culture' of gluttony at the Court of King James still stands as a stereotype largely left unchanged by the recent revisionist historiography. This dissertation argues that James's Court was unexceptional when placed in the context of other English and European Courts. Polemical attacks on the culture of 'gluttony' at the Court of King James were motivated by political contest. Proximity to the King's person allowed for unrivalled privilege and reward. The attacks on James's new favourites came from the old nobility, once at the centre, and now relegated to the periphery, while those targeted, James's 'new men', came from the periphery. Competition for resources also informed the allegations of cannibalism made against New World peoples. Under the Spanish, attacks against the 'cannibals' at the periphery were designed to justify the appropriation of their resources. The English, when their opportunity came, could no longer convincingly accuse those at the periphery of cannibalism. New economic arguments and empirical science together promoted a new focus on 'culture', which suggested that Amerindians belonged at the periphery. At some stage in their 'development' and under proper Christian tutelage, and if they behaved themselves, they might be incorporated into the centre. In the meantime, English 'trade and friendship' would assist in their education. This dissertation makes an original contribution by demonstrating that bodily practices sit at the heart of enduring political contests.</p>
3D Seismic Traveltime Tomography of the Central South Island, New Zealand
Authors:   , Brikke Nicolas Eduard Alype 
Published: November 2021

<p>The three-dimensional (3D) evolution of the Australian-Pacifi c late boundary in the central South Island of New Zealand is investigated by analysing seismic data from the South Island GeopHysical Transect (SIGHT) project and by using a novel 3D tomography inversion method, FMTOMO. A 380 km-long, 350 km-wide and 56 km-deep 3D tomography image of the P-wave velocity structure and interface geometry of the crust and upper-mantle is constructed by inverting for 164,048 traveltime picks. The picks are both coincident (in-line) and oblique (cross-line) to the survey geometry. The traveltime picks and station elevations were static corrected and reduced to basement level, respectively, to eliminate the highly variable sedimentary component of the inversion process. Synthetic testing of the model space was carried out to help the interpretation of the solution model features. Some model features are consistent with previous results. Usual crustal velocities (5.5 km/s close to the surface and 6.3 km/s at the bottom of the crust) are found at distal ends of the collision zone. Lower velocities (5.7 km/s) intrude the mid-crust of the Australian plate to depths of about 20 km, which is consistent with the downward flexure of the Australian plate. A low velocity zone (5.9 - 6.1 km/s) is situated to the southeast of the Alpine fault, which is consistent with the Alpine fault low velocity zone. Furthermore, a high-velocity body (6.3 km/s) is observed in the top 10 km of the upper-crust immediately above the thickened crust between the west coast of the South Island and the Main Divide of the Southern Alps. This body is interpreted as a drier, more rigid body of schist. A zone of low velocity (5.8 km/s reaching 8 km depth) is observed immediately to the southeast of the aforementioned high velocity body. The feature is interpreted as a back-shearing faulting structure through which fluid escape towards the surface. A flexural analysis of an apparent flexure profile of the Australian Plate along SIGHT line 01 yielded a flexural parameter, a, of 89 km, an elastic thickness, Te, of 14 km and a flexural rigidity, D, of 1.5 : 10^(23) N.m. These results are consistent with results of a flexural analysis of SIGHT line 02W [Harrison 1999]. The following features are derived from the solution model. An apparent gradient in uppermantle anisotropy is observed with seismic velocities increasing towards the south of the model. Also, the geometry of the Mohorovicic discontinuity is apparently smooth between the two main SIGHT transects. The tomography method used in this project proves to be complementary to other coarser-scale and finer-scale seismic studies of the region in that it brings out features that were not seen by them. Notwithstanding that the interface inversion process remains to be perfected in the software, the velocity inversion produced a satisfactory solution model.</p>
"Was That My Misunderstanding?": Managing Miscommunication and Problematic Talk at Work
Authors:   , Stubbe Maria 
Published: November 2021

<p>Where workplace communication is ineffective or problematic there will often be negative outcomes for individuals, teams or organisations as a whole. This thesis examines these issues using data from a variety of New Zealand workplaces, including most importantly an in depth case study of problematic communication in a multicultural factory team. The thesis provides an illustrative analysis of the communication issues that typically arise in these workplaces and the discursive strategies used to manage miscommunication and problematic talk, as well as exploring some of the analytic and theoretical issues which emerge when we attempt to identify instances of miscommunication and diagnose how they came about. The practical implications for workplaces are also discussed. After evaluating previous approaches, the author proposes a comprehensive working model for analysing miscommunication or problematic discourse in workplace interaction which is based on a flexible multi-layered theoretical and methodological framework. The analytic approach taken is to apply the tools of sociolinguistic discourse analysis to data from actual interactions along with associated ethnographic information, in conjunction with a critical analysis of organisational communication practices and processes as seen from a community of practice perspective. A multi-dimensional intertextual approach such as this allows analysis of miscommunication and problematic talk at a number of different levels in order to relate what is happening sequentially and 'on-line' during particular interactions or sequences of interaction to factors such as social identity, group membership, team culture and other aspects of the wider communicative and socio-cultural context.</p>
Area Assessment of a Pedestrian Wind Environment Using Point Wind Speed Measurements
Authors:   , Kepka Benjamin Jan 
Published: November 2021

<p>This research has successfully produced a means of creating a reliable area measurement of a pedestrian level wind environment from a reasonable number of point wind speed measurements. To complete this aim a contouring script was developed through MATLAB. The script has the ability to read in series of point wind speed measurements coupled with cartesian co-ordinates and generate a reliable contour diagram. The foundation for this research is a resource of over 150 wind tunnel tests conducted for code compliance in Wellington City. The District Plan in Wellington requires any building over 18.6m in height to have a wind tunnel analysis conducted to assess the changes in wind speed with respect to pedestrian safety. Wellington compliance criteria require two forms of measurement to be conducted. Point measurements are taken to quantify wind speeds accurately, but are unable to efficiently assess large areas. Area measurement techniques are used to assess the comparative windiness of zones around the development site. Through examination of 3000 measured data points it has been demonstrated that the correlation between these two measurement techniques is relatively low. Until now, neither test alone has been sufficient to accurately quantify the impact of a new development on the pedestrian level wind environment as a whole. Interpolation methods were used to generate pseudo measurements between points at which wind speeds were measured. A series of three building configurations were assessed using the MATLAB script to visualise the effect of increasing building height on pedestrian level winds. The building configurations assessed were: a uniformly distributed grid of 25 half cubes (60m x 60m x 30m), central full cube (60m x 60m x 60m), and, a central tall tower (60m x 60m x 240m). Each building configuration was simulated through the contouring script and the resultant contours were assessed to ensure a realistic depiction of easily predictable wind flow patterns such as downwash and the corner effect. The resolution of the output contours in any case is directly related to the number of point wind speed measurements used. It has been found that measurement points should be more densely located (15m in scale) around the site in question, and more sparsely located (30m in scale) around the outer regions of the desired testing area. This is the most efficient method of generating contours for use in commercial pedestrian level wind laboratories. Mathematically generated contours have the potential to provide a more reliable output than those produced through current methods of area testing.</p>
Logic of Appropriateness or Logic of Consequence? Competing Explanations for the OECD Campaign against Tax Havens
Authors:   , Wood Melinda 
Published: November 2021

<p>This thesis provides an alternative explanation to existing constructivist accounts of the OECD campaign against tax havens. It reinterprets the OECD project through a neoliberal institutionalist lens and offers a different take on each major historical development. It brings the narrative up to date, describing the events of the past two years and explaining the underlying causes in a manner consistent with the neoliberal reinterpretation. It finishes by considering what this account might predict for the future of tax information exchange. The thesis finds that transformative change happens in accordance with state interests rather than with identities and norms. International institutions fundamentally exist to advance the interests of their memberstates and will adapt their goals to reflect changing collective interests. States that are coerced to change their behaviour can be expected to comply only to the extent required to avoid sanctions.</p>
Perspectives on Developing a Music Therapy Programme Within an Educational Setting for Adolescents with Mental Health Issues
Authors:   , Young John-Paul 
Published: November 2021

<p>This thesis outlines exploratory research that sought to find out how music therapy could most effectively address the needs of the students and support the ideas and learning objectives of staff at an innovative new school for adolescents with mental health issues. This was achieved by involving staff and students (n=12) in a series of group interviews, in combination with reflections from a research journal. Amongst other things, the findings suggested that students valued the opportunity to learn new musical skills, relax and express themselves. The staff appeared to value the way music therapy could support therapeutic and educational objectives within the school; for instance, by providing students with opportunities to work together in small groups, or by providing individual students with a way of relaxing and experiencing success. The writer describes efforts to tailor music therapy to fit with the needs of the setting and concludes by suggesting possible avenues for future music therapy research in a setting of this kind.</p>
Evaluation of Appreciative Inquiry Interventions
Authors:   , Stellnberger Martin 
Published: November 2021

<p>As a relatively new tool for organization development, action research, training and team building, Appreciative Inquiry (AI) has gained popularity worldwide (Messerschmidt, 2008). Whilst much research has addressed the approach and its philosophy, AI still remains an approach with little self-reflection or critique (Grant & Humphries, 2006). It has been suggested that evaluation of past AI interventions is needed to inform managerial action in conducting future interventions and contribute to the literature on AI (Dunlap, 2008). In this thesis, three large-scale AI interventions (between 130 and 320 participants in the summit) were evaluated. Three organizations operating in New Zealand and Australia agreed to participate in this research. Across these three organizations, data were collected through 23 semi-structured interviews of employees who were involved in the AI summit. Evaluation of these interventions was carried out by comparing the findings of the interviews with the intended goals and outcomes for each organization in initially performing an AI summit. In addition, the findings were contrasted with the existing literature on AI and recommendations for future implementations are made. This research shows that the interviewees across the three organizations consistently reflected very positively on the AI summit. They commonly used words like 'fun', 'great', 'amazing', 'exciting', 'energizing', 'motivating' and 'making you feel special' to describe the event. Particularly, the involvement of a diverse group of people (co-workers from different management levels, customers, suppliers, external partners, etc.) in the summit was highly appreciated by the interviewees. While the literature puts a great emphasis on the AI summit and the planning of the event, the findings indicate that the things that happen post the summit are at least as important as the actual summit itself. Two out of three organizations appear to have underestimated the importance of what should happen after the event and ultimately failed in integrating AI into their organizational processes or capturing significant benefits following the AI summit. In contrast, the third organization put a strong emphasis on planning actions that followed the summit and consequently managed to make AI part of their way of operating.</p>
Collateral Damage: A Mixed Methods Study to Investigate the Use and Withdrawal of Antidepressants Within a Naturalistic Population
Authors:   , Thrasher Susan 
Published: November 2021

<p>The use of modern antidepressants has flourished over the past few decades with the modern attribution of affective disorders such as depression to biomedical causation. However, recent re-examination of clinical trials has raised questions regarding antidepressant drug efficacy, and issues around side effects and dependency are prevalent. In spite of this, as many as 10% of us may be taking these medications (Szabo, 2009). This study examines responses to an anonymous online survey about antidepressant use and withdrawal. Participants included 176 current users, 181 currently withdrawing, 108 ex-users, and a control group of 44 participants who had never used antidepressants. Participant groups were compared quantitatively regarding attitude towards antidepressants use and perceived value, effect on well-being and mood, symptoms and side effects, and their perceived changes in themselves on and off the drugs. Participants were also given the opportunity to include spontaneous comments at the end of the survey which were analysed thematically. Key findings include: 1) Antidepressant users have a more positive estimation of the value of the drugs than those who have discontinued the drugs or who have never used them; 2) Scores on the WHO-5 well-being survey for all three groups with antidepressant experience (users, those withdrawing, and ex-users) showed poor levels of wellbeing, suggesting that neither antidepressant therapy nor cessation of antidepressant therapy were adequate interventions to create positive well-being; 3) Multivariate analysis of participant responses revealed a significant difference between the four groups on 35 of 37 physical and emotional symptoms associated with antidepressant use or withdrawal, with the never-used group scored the lowest in all cases except one, and the withdrawing group scoring the highest for 27 of the symptoms; 4) Concern over antidepressant dependency and withdrawal was the most prevalent topic reported by all user groups in spontaneous comments; other key themes included frustration with side effects and lack of information and support from the medical profession; 5) study results suggest that antidepressant withdrawal may take longer and be more challenging than the assumed "mild", "self-limiting" and "resolving spontaneously…three weeks after onset" (Haddad & Anderson, 2007); and 6) 30% of ex-users spontaneously reported what they believed were adverse drug reactions, or withdrawal reactions, months or years after antidepressant use had ceased, a long-term iatrogenic disablement that has yet to be addressed in the literature. Overall, the study reveals that antidepressants are not an adequate intervention to create positive well-being in patients and their use comes with a substantial risk of unpleasant side effects, dependency, and the potential for residual post-drug health complications.</p>
The Microstructure and Rheology of Complex Fluids Containing Na-caseinate
Authors:   , Tan Hui Lin 
Published: November 2021

<p>Emulsions are widely utilised in commercial environments, such as in the food and cosmetic industries. In their simplest form, emulsions are a system consisting of two immiscible liquids in the presence of emulsifiers. To form an emulsion, an input of energy is required. In this thesis, Na-caseinate was used as the emulsifier and three systems were studied: soybean oil/Na-caseinate/water, palm oil/Na-caseinate/water and tetradecane/Nacaseinate/ water. Four main techniques were used to characterise the stabilised emulsions: laser diffraction particle sizing, PGSTE-NMR, rheology and cryo-SEM. Emulsion systems are extremely complex making control and predictability over their phase behaviour practically difficult. This is because the required overall characteristics of these colloids are strongly dependent on both the energy of formulation and the choice of an appropriate combination of emulsifier, dispersed phase and continuous phase. A full understanding of the microstructure, stability and physicochemical properties of caseinatestabilised emulsions has as yet not been achieved. For example, how does caseinate selfassembly control emulsion stability? How do concentrated caseinate-based emulsions differ from dilute ones and how do the different oils (food grade oils vs. straight chain hydrocarbon) affect the formation of emulsions? The aim of this PhD programme was to obtain data to allow a better fundamental understanding of the underlying parameters defining emulsion behaviour to be obtained ...</p>
Monte Carlo Valuation of Corporate Bonds Using Price Data
Authors:   , Patel Nimesh 
Published: November 2021

<p>Corporate debt securities play a large part in financial markets and hence accurate modeling of the prices of these securities is integral. Ericsson and Reneby (2005) state that the corporate bond market in the US doubled between 1995 and 2005 and is now larger than the market for US treasuries. Although the theoretical corporate bond pricing literature is vast, very little empirical research to test the effectiveness of these models has been published. Corporate bond pricing models are split into two families of models. The first, are the structural models which endogenise default by modeling it as an event that may eventuate due to the insolvency of the underlying firm. The second family of models is the newer class of reduced-form models that exogenise default by modeling it as some random process (default intensity). The reduced-form models have been formulated largely due to the empirical failures of the structural family to accurately model prices and spreads. However as Ericsson and Reneby (2005) point out, an inadequate estimation approach may explain the poor performance of the structural models. Structural models are, therefore, the focus of this paper. We, however, do estimate a reduced-form model in order to make a comparison between the two types of model. There are no published papers (to my knowledge) in which both types of model are implemented ...</p>