bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Tripterygium Wilfordii Hook. F for Connective Tissue Disease-Associated Interstitial Lung Disease:A Systematic Review and Meta-Analysis
Authors: Li Yehui , Zhu Wen , He Hailang , Garov Yordan Angelov , Bai Le , Zhang Li , Wang Jing , Wang Jinghai , Zhou Xianmei 
Published: June 2021

Background: Tripterygium wilfordii Hook. F (TwHF), a Chinese herbal medicine used to treat CTD-ILD patients in China, has been previously found to have immunoinhibitory, antifibrotic and anti inflammatory effects. It has also shown good results in treating autoimmune and inflammatory diseases.Objectives: This systematic review and meta-analysis aims to evaluate the efficacy and safety of TwHF for CTD-ILD.Methods: A systematic search was performed on PubMed, Embase, Cochrane Library, Web of Science, PsycINFO, Scopus, CNKI, Wanfang, VIP, and CBM databases up to May 2021. Randomized controlled trials (RCTs) comparing TwHF plus conventional therapy versus conventional therapy alone were included. We followed the PRISMA checklist, and applied Cochrane handbook 5.1.0 and RevMan 5.3 for data analysis and quality evaluation of the included studies.Results: Based on Cochrane handbook 5.1.0, nine RCTs consisting 650 patients met the inclusion/exclusion criteria and were selected for further analysis. The obtained data showed significant improvement in lung function with TwHF plus conventional treatment compared with conventional treatment (post-treatment FVC% (MD= 8.68, 95%Cl (5.10, 12.26), p &lt; 0.00001), FEV1% (MD = 11.24, 95%Cl (6.87, 15.61), p &lt; 0.00001), TLC% (MD = 5.28, 95%Cl (0.69, 9.87), p = 0.02)], but no significant difference in the post-treatment DLCO% [(MD = 4.40, 95%Cl (−2.29, 11.09), p = 0.20)]. Moreover, the data showed that TwHF combined with conventional treatment significantly reduced the HRCT integral of patients [MD = -0.65, 95% (-1.01, -0.30), p = 0.0003], the level of erythrocyte sedimentation rate (MD = −9.52, 95%Cl (−11.55, −7.49), p &lt; 0.00001), c-reactive protein (CRP) (MD = −8.42, 95%Cl (−12.47, −4.38), p &lt; 0.0001), and rheumatoid factor (MD = −25.48, 95%Cl (−29.36, −21.60), p &lt; 0.00001). Compared to conventional therapy, TwHF combined with conventional therapy significantly improved clinical effects (RR = 1.33, 95%Cl (1.17, 1.51), p &lt; 0.0001), in five trials with 354 patients. In terms of improvement of symptoms and signs, the TwHF group showed a more significant improvement than the conventional treatment group (Cough (MD = −0.96, 95%Cl (−1.43, −0.50), p &lt; 0.0001), velcro rales (MD = −0.32, 95%Cl (−0.44, −0.20), p &lt; 0.00001), shortness of breath (MD = −1.11, 95%Cl (−1.67, −0.56), p &lt; 0.0001)], but no statistical difference in dyspnea (MD = −0.66, 95%Cl (−1.35, 0.03), p = 0.06). There was no statistical significance in the incidence of adverse reactions.Conclusion: The performed meta-analysis indicated that TwHF combined with conventional treatment was more beneficial to patients for improving symptoms, lung function and laboratory indicators. As it included studies with relatively small sample size, the findings require confirmation by further rigorously well-designed RCTs.
Misunderstandings in ART Triadic Interactions: A Qualitative Comparison of First and Follow-Up Visits
Authors: Rossi Maria Grazia , Vegni Elena , Menichetti Julia 
Published: June 2021

BackgroundMisunderstandings in medical interactions can compromise the quality of communication and affect self-management, especially in complex interactions like those in the assisted reproductive technology (ART) field. This study aimed to detect and describe misunderstandings in ART triadic visits. We compared first and follow-up visits for frequency, type, speakers, and topics leading to misunderstandings.MethodsWe purposively sampled 20 triadic interactions from a corpus of 85 visits. We used a previously developed coding scheme to detect different types of misunderstandings (i.e., with strong, acceptable, and weak evidence). We analyzed also the different topics leading to strong misunderstandings (direct expressions of lack of understanding, pragmatic alternative understandings, semantic alternative understandings) to provide insights about the contents of the consultation that may need particular attention and care.FindingsWe detected an overall number of 1078 misunderstandings in the 20 selected visits. First visits contained almost two-third of the misunderstandings (n = 680, 63%). First visits were particularly rich in misunderstandings with acceptable evidence (e.g., clarifications and checks for understanding), compared to follow-up visits. In first visits, doctors’ turns more frequently than couples’ turns contained misunderstandings, while in follow-up visits it was the other way around. Looking at the couple, the majority of the misunderstandings were expressed by the woman (n = 241, 22%) rather than by the man (n = 194, 18%). However, when weighting for their number of turns, 9% of the men’s turns included an expression of misunderstanding, compared to the 7% of the women’s turns. Finally, more than half of the misunderstandings with strong evidence were about history-taking and treatment-related topics, and while the history-taking ones were particularly frequent in first visits the treatment-related ones were more present in follow-up visits.DiscussionFindings indicate that first visits may deserve particular attention to avoid misunderstandings, as they are the moment where a shared understanding can be harder to reach. In particular, misunderstandings happening in first visits seem mostly related to physicians having to reconstruct the clinical history of patients, while those in the follow-up visits seem to reflect residual and unsolved doubts from the couple, especially concerning treatments.
Effects of Tai Chi on the Executive Function and Physical Fitness of Female Methamphetamine Dependents: A Randomized Controlled Trial
Authors: Menglu Shen , Ruiwen Liu , Suyong Yang , Dong Zhu 
Published: June 2021

Purpose: Exercise improves the health and mental status of drug dependents. The way by which Tai Chi (TC) as a special exercise treatment affects executive functions (EFs) of methamphetamine (MA) dependents is yet to be established. This study aimed to explore the effects of TC on the EFs and physical fitness of MA dependents.Methods: A total of 76 female MA dependents were randomly assigned to the exercise and control groups. The exercise group underwent three 60-min sessions of TC training per week for 12 weeks. The control group was trained with conventional exercises including the 9th Guang Bo Ti Cao and square dance. Physical fitness and EF assessments that evaluated inhibitory control (IC, go/no-go task), working memory (3-back task) and cognitive flexibility (switching task) were performed at baseline and at 12 weeks. A repeated-measures ANOVA was applied to analyze the differences of group and time.Results: The exercise group showed decreased response time (RT) with a significant main effect of time on the go/no-go task [F(1, 68) = 9.6, p &lt; 0.05]. The interaction effect between time and group was significant on accuracy [F(1, 61) = 4.73, p &lt; 0.05], and the main effect of time was significant on RT [F(1, 61) = 4.66, p &lt; 0.05] in the 3-back task of the exercise group. Significant changes in BMI [F(1, 68) = 19.57, p &lt; 0.05], vital capacity [F(1, 68) = 6.00, p &lt; 0.05], and systolic blood pressure [F(1, 68) = 6.11, p &lt; 0.05] were observed in the exercise group.Conclusion: These findings showed that 3 months of TC training can improve the IC and maintain the working memory and cognitive flexibility of MA dependents. Other data implied that TC may improve the physical fitness of MA dependents.Clinical Trial Registration:http://www.chictr.org.cn/, ChiCTR1900022091.
Case Report: De Clerambault's Syndrome in Dementia With Lewy Bodies
Authors: Suehiro Takashi , Satake Yuto , Hashimoto Mamoru , Ikeda Manabu 
Published: June 2021

Background: Erotomania, also known as de Clerambault's syndrome, is characterized by the delusion that a person has fallen in love with the patient. It occasionally appears secondary to psychiatric disorders and organic brain diseases. However, there have been no reports on cases secondary to dementia with Lewy bodies (DLB).Case Presentation: The patient was an 83-year-old woman who lived alone. Mild cognitive impairment appeared at the age of 82 years. Soon after, she had the delusional conviction that her family doctor was in love with her. Her symptoms, such as gradually progressive cognitive impairment, cognitive fluctuations, and parkinsonism, indicated DLB. She was treated with a small dose of antipsychotic agents.Conclusions: This case report suggests the possibility of de Clerambault's syndrome during the early stages of DLB. Further investigations are required to clarify the mechanism and treatment of de Clerambault's syndrome in patients with DLB.
Psychological Distress, Loneliness, and Boredom Among the General Population of Tyrol, Austria During the COVID-19 Pandemic
Authors: Tutzer Franziska , Frajo-Apor Beatrice , Pardeller Silvia , Plattner Barbara , Chernova Anna , Haring Christian , Holzner Bernhard , Kemmler Georg , Marksteiner Josef , Miller Carl , Schmidt Martin , Sperner-Unterweger Barbara , Hofer Alex 
Published: June 2021

Background: COVID-19-related mental health problems are considered a public health challenge. The aim of this study was to investigate psychological distress, loneliness, and boredom among the general population of the federal state of Tyrol, Austria.Methods: Residents of Tyrol aged ≥ 18 years were recruited via dissemination of a link through social media and other advertisements and invited to complete an online survey from June 26th to August 20th, 2020. Next to the collection of sociodemographic and COVID-19 related variables the Brief Symptom Checklist (BSCL), the Three-Item Loneliness Scale (TILS), and the Multidimensional State Boredom Scale-Short Form (MSBS-SF) were used to assess psychological distress, loneliness, and boredom.Results: 961 participants took part in the survey (68.3% woman). Of these, 14.4% were burdened from psychological distress (BSCL), 22.6% reached a TILS score ≥ 7 and were therefore classified as severely lonely, and boredom levels lay by a mean of 25.9 ± 11.0 points in the MSBS-SF (range: 7–56). Women, singles, low-income people as well as those who were unemployed were significantly more often affected by all of the selected outcomes compared to the remaining sample and they had significantly more frequently consumed alcohol or other substances since the outbreak of the pandemic in order to feel better. In addition, young and middle-aged adults were particularly burdened by loneliness and boredom.Discussion: Our findings identify vulnerable groups and factors associated with higher psychological distress, loneliness, and boredom in the context of the pandemic. In order to prevent mental health problems it will be critical to identify options of maintaining social contacts and remaining active despite pandemic-related restrictions.
Perceptions of Study Conditions and Depressive Symptoms During the COVID-19 Pandemic Among University Students in Germany: Results of the International COVID-19 Student Well-Being Study
Authors: Matos Fialho Paula Mayara , Spatafora Franca , Kühne Lisa , Busse Heide , Helmer Stefanie M. , Zeeb Hajo , Stock Christiane , Wendt Claus , Pischke Claudia R. 
Published: June 2021

Background: Results of previous studies examining the impact of the SARS-CoV-1 epidemic in 2003 on university students' mental well-being indicated severe mental health consequences. It is unclear how the current COVID-19 pandemic and the changes in study conditions due to federal regulations affected mental well-being in the German student population. We examined university students' perceptions of study conditions during the COVID-19 pandemic and investigated associations between study conditions and depressive symptoms.Methods: A cross-sectional online survey was conducted in Germany in May 2020 at four universities (N = 5,021, 69% female, mean age: 24 years, SD: 5.1). Perceived study conditions, as well as sociodemographic information, were assessed with self-generated items and the CES-D 8 scale was used to determine depressive symptoms. Associations between perceived study conditions (academic stress and academic satisfaction), in general, and confidence to complete the semester, in particular, and depressive symptoms were analyzed using generalized linear regressions.Results: Fifty-four percent of survey participants felt that the university workload had significantly increased since the COVID-19 pandemic; 48% were worried that they would not be able to successfully complete the academic year; 47% agreed that the change in teaching methods caused significant stress. Regarding depressive symptoms, the mean score of the CES-D 8 scale was 9.25. Further, a positive association between perceived study conditions and depressive symptoms was found (p &lt; 0.001), indicating that better study conditions were associated with fewer depressive symptoms. Results of the generalized linear regression suggest that better student mental well-being was related to higher confidence in completing the semester.Conclusions: This study provides first insights into perceived study conditions and associations with depressive symptoms among students during the COVID-19 pandemic in Germany. Findings underline the need for universities to provide intervention strategies targeting students' mental well-being during the course of the pandemic.
Special Issue of the Manufacturing Engineering Society 2020 (SIMES-2020)
Authors: Rubio Eva María , Camacho Ana María 
Published: June 2021

The Special Issue of the Manufacturing Engineering Society 2020 (SIMES-2020) has been launched as a joint issue of the journals “Materials” and “Applied Sciences”. The 17 contributions published in this Special Issue of Materials present cutting-edge advances in the field of Manufacturing Engineering, focusing on additive manufacturing and 3D printing; advances and innovations in manufacturing processes; sustainable and green manufacturing; manufacturing of new materials; manufacturing systems: machines, equipment and tooling; robotics, mechatronics and manufacturing automation; metrology and quality in manufacturing; Industry 4.0; design, modeling and simulation in manufacturing engineering. Among them, this issue highlights that the topic “advances and innovations in manufacturing processes” has collected a large number of contributions, followed by additive manufacturing and 3D printing; sustainable and green manufacturing; metrology and quality in manufacturing.
A, Dwi Rindi PERBANDINGAN UJI METABOLIT SEKUNDER PADA EKSTRAK BUAH, KULIT, DAN DAUN MAJA DENGAN METODE SPEKTROFOTOMETRI UV-VIS
Authors: Atika Dwi Rindi 
Published: June 2021

Introduction Some plants in Indonesia contain secondary metabolites and antioxidants, one of which is the Maja Plant. The part of the maja plant used in this research is the structure of the plant which includes the fruit, skin and leaves because it is thought to have antioxidant content. Purpose this study was to compare secondary metabolites found in the fruit, skin and leaves of maja. And to determine the antioxidant activity in these samples. Method experimental study method was used in this research. The population used is the maja plant. Samples were obtained from the Slerok Village, Tegal City, Central Java using the simple random sampling technique. Results The results yield extracts of maja fruit, skin, and leaves were 48,5%, 90,4% and 32,8%, respectively. The fruit, skin and leaf extracts of maja have the same secondary metabolite content in the form of tannins, alkaloids (Wagner), and vitamin C. While the IC50 obtained in the fruit, skin and leaf extracts of maja are 2897,3434 ppm, 7321,49 ppm, and 37,0937 ppm. Conclusion of this study is that there are secondary metabolites in the extracts of fruit, skin and leaves of maja. And the strongest antioxidant activity is found in maja leaf extract. Suggestion Further researchers are expected to be able to carry out research again with different extraction methods in order to know the results of different extraction methods.
PERILAKU ORANGTUA DALAM UPAYA PENCEGAHAN COVID 19 PADA ANAK
Authors: Aini Nurul , Anggraini Ika Rizki , Alifatin Aini 
Published: June 2021

Pendahuluan Pandemi covid 19 mulai memberikan dampak secara global, sehingga hampir semua negara harus menghadapi krisis kesehatan dan social ekonomi yang parah, bahkan belum pernah terjadi sebelumnya. Aktifitas kehidupan anak dan keluarga seakan terhenti, tak terkecuali, negara Indonesia turut merasakan hal ini. Penyakit yang dimunculkan akibat infeksi covid 19 dapat menyerang siapa saja. Hingga saat ini tercatat ada 145 anak meninggal dunia akibat virus corona baru atau COVID-19 di Indonesia, jauh lebih tinggi dibanding negara-negara lain (Ainun Najib, 2020). Negara Indonesia memegang rekor tertinggi dalam hal tingkat kematian anak di Asia Pasifik akibat covid 19 dengan rata-rata sebesar 2,5% (IDAI, 2020). Guna mendukung upaya yang telah digalakkan oleh pemerintah, maka peran unit terkecil yaitu keluarga sangatlah penting. Kendali kehidupan anak-anak terletak pada tingkat ketrampilan orangtua dalam menerapkan pola asuh yang memadai. Pada masa pandemic covid 19 saat ini, perilaku orangtua dalam hal kesehatan sangat dibutuhkan. Tujuan penelitian ini untuk mencari gambaran bagaimana perilaku orangtua dalam upaya pencegahan covid 19 pada anak. Metode penelitian menggunakan deskripsi observasional, dengan populasi semua orangtua yang memiliki anak usia 1-12 tahun. Sampel penelitian diambil dengan menggunakan accidental sampling. Hasil penelitian, ditunjukkan uji spearman rank didapatkan koefisien korelasi sebesar 0,447 dan p value sebesar 0,054 (α<0,05). Kesimpulan ada hubungan antara perilaku orang tua terhadap pencegahan covid-19 dengan usia anak dengan tingkat hubungan yang cukup kuat (r=0,047) dan berpola positif, dimana makin bertambah usia anak, maka akan meningkatkan perilaku orang tua terhadap covid-19. Saran dalam penelitian selanjutnya untuk mengembangkan variable penelitian ini dengan cakupan responden yang lebih banyak dan analisis yang lebih akurat.

Keyword : perilaku orangtua, pencegahan covid 19, anak
THE IMPLEMENTATION OF DIABETIC SELF-MANAGEMENT IN INDONESIA AND TAIWAN HOSPITAL: A CASE STUDY DESIGN
Authors: Pranata Satriya , Hwang Hei-Fen 
Published: June 2021

Background:
Population of people with diabetes mellitus (DM) are increasing every year. As a chronic illness, patients with DM needs to practice self-management for life. Adopted the nursing system in other countries that are more advanced in DM care, however the study is still under investigation.
Objectives: Primary objective was to analyze the diabetic Self-management among the Indonesian and Taiwan population in Hospital. Secondary was to develop theory-guided and/or evidence-based nursing model in the self-management among diabetic patient with practical issues.
Methods: We used a case study design by discussion across the multi-discipline of health care provider point of view, observation and brief interview session with patient, observe the health care model, learning process of health education between nurse and patient and whole application of the health education, at Veteran Hospital in Taiwan and Manambai Abdulkadir Hospitals in Indonesia.
Results: Education system related to self-management of DM patients have been running and prepared by the Veteran hospital in Taiwan. The health system for diabetes management was called by diabetes shared care. Nurse, nutritionist and doctor have similar opinions about self-management in DM patients in Taiwan but different perspective among health professionals in Indonesia. The process of applying of evidence-based nursing practice and guidelines for providing health education to patients in Veteran Hospital Taiwan was using guidelines from the diabetes federation of China (Taiwan), on the other hand, standard operating procedure in Hospital in Manambai Abdulkadir Hospital, Indonesia, it is due to different policy in each country.
Conclusion: The model of self-management might can be successfully be applied in clinical setting with several strategies by resolve the challenges. Hopefully, this study can be providing valuable information to the health professionals in order to provide the best service for patients with DM.

Keywords: Diabetes, self-management, model, health education.
ANALYSIS OF DETERMINANT FACTORS OF AFFECTING FAMILY ABILITY IN HIGH-RISK PREGNANCY
Authors: Mardiyanti Ika , Anggasari Yasi 
Published: June 2021

Background: The ability of pregnant women to deal with early response to high risks is still below the average, which is one of the causes of complications that can indicate the welfare of the mother and her fetus.
Objectives: The aim of this study was to look at the determinants that influence early detection of high-risk pregnancies.
Methods: This study used an analytic design with a cross sectional design. The sample size of 112 from a population of 155 was obtained by simple random sampling. The independent variables are individual factors, interpersonal influence, filial value and commitment, while the dependent variable is the family's ability to detect high risk of pregnancy for 3 months, namely August-October 2020 at PMB Ika Mardiyanti. This study uses a questionnaire. Data collection in the form of a questionnaire. Data analysis using SEM-PLS.
Results: The results of the significance test concluded that all the path coefficients and the T statistical value of personal factors on interpersonal (0.453; 6.612), interpersonal on filial values ​​(0.753; 7.267), filial value for commitment (0.851; 17.048), filial value for ability (0.667 ; 4,679), commitment to ability (0.358; 2.356) is significant. Because all have a T-statistic value that is more than the T-table 1.96.
Conclusion: The determinant factors that contribute to the ability of families to detect high risk of pregnancy need to be considered so that families are independent and have efforts to maintain the health of pregnant women in their families. In further research, it is necessary to involve other factors to improve family capacity, especially in the ability of families to detect high-risk pregnancies early.

Keywords: Ability, family, high-risk.
БІОХІМІЧНІ ПОКАЗНИКИ КРОВІ КОТІВ ПРИ ХРОНІЧНІЙ НИРКОВІЙ НЕДОСТАТНОСТІ
Authors: Яцина С. , Супрович Т. 
Published: June 2021

Представлено результати біохімічного дослідження крові котів з хронічною нирковою недостатністю у порівнянні із здоровими тваринами. Встановлено взаємозв’язок між основними симптомами хвороби і біохімічними змінами в крові тварин. У хворих котів рівень креатиніну був вищий у 2,01 рази (Р˂0,001) порівняно із здоровими тваринами; рівень сечовини був вищим у 1,8 рази (Р˂0,001); показник фосфору був більше у 1,5 рази (Р˂0,001).
Визначено, що активність ферменту аланінамінотрансферази у хворих котів становила 58,3±2,0 Од/л і була у 1,6 рази (Р˂0,001) більше; гамма-глутамілтрансферази становила 4,3±0,50 О д/л і була більше в 1,8 рази (Р˂0,01) порівняно із здоровими котами.