bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stabilised explicit Adams-type methods
Authors: Repnikov Vasily I. , Faleichik Boris V. , Moisa Andrew V. 
Published: September 2021

In this work we present explicit Adams-type multi-step methods with extended stability intervals, which are analogous to the stabilised Chebyshev Runge – Kutta methods. It is proved that for any k ≥ 1 there exists an explicit k-step Adams-type method of order one with stability interval of length 2k. The first order methods have remarkably simple expressions for their coefficients and error constant. A damped modification of these methods is derived. In the general case, to construct a k-step method of order p it is necessary to solve a constrained optimisation problem in which the objective function and p constraints are second degree polynomials in k variables. We calculate higher-order methods up to order six numerically and perform some numerical experiments to confirm the accuracy and stability of the methods.
Vladimir Mironov’s metaphysics and university education transformation
Authors: Danilov Alexander N. 
Published: September 2021

The article deals with the specificity of philosophical knowledge, metaphysics as its semantic core and the problems of transforming modern humanitarian university education, which was developed in the work of Vladimir Mironov. V. V. Mironov is a well-known Russian scientist, doctor of philosophy, professor, corresponding member of the Russian Academy of Sciences, dean of the faculty of philosophy of the Lomonosov Moscow State University. The author analyses current problems related to the role of philosophy in shaping the image of the future in modern culture, reforming university education, the consequences of introducing scientometric methods into the educational process, the readiness of higher education responding to the challenges of the times, global instability, commercialisation, digitalisation, etc. The scientific position of V. V. Mironov on topical problems of transforming modern society, its assessment and reflections on the prospects for teaching philosophy and the humanities.
Transformation of family values of Belarusians in the reflection of the media (the example of the magazine «Rabotnica i sjaljanka»)
Authors: Artsiomenka-Melyantsova Alena K. 
Published: September 2021

The article examines the change in family values in Belarus as reflected in the materials of the magazine «Rabotnica i sjaljanka» from the 1960s to the 2010s. Based on the analysis of the thematic distribution of publications, the characteristics of the heroines, the female duties declared by the magazine and the presentation of the topic of marriage and family at the level of rhetoric, the following conclusions are drawn. In reflecting the materials of the magazine after the 1990s, the role of family and marriage is increasing, the professional roles and responsibilities of a woman are supplemented by the need to show skill in everyday life, to maintain beauty and attractiveness, which corresponds to the tendencies of traditionalisation of values according to survey data. At the same time, the increase in divorce rates and a decrease in the number of children in the family are normalised.
FAKTOR-FAKTOR PENENTU PERILAKU GURU SMP MENGGUNAKAN TEKNOLOGI DALAM PEMBELAJARAN ONLINE: STUDI KASUS DI PROVINSI RIAU
Authors: Hamka Defrizal , Sholihat Neng 
Published: September 2021

The purpose of this research is to investigate factors that influence the intent of behavior using technology in online learning. The study uses structural equation modeling using a partial least square approach to test the hypotheses. Respondents selected using purposive sampling, and the questionnaires were distributed through online surveys and received a response of 96 respondents. Results show that latent variables, performance expectations, business expectations, and facility conditions have a positive and significant relationship with the intent of individual behaviour in the use of technology in online learning. The latent variable "condition facility" is the most influential factor. This research provides an important overview and understanding for policymakers in designing frameworks to pay attention to facility conditions. Further research is suggested in the future covering samples from various provinces in Indonesia. This study adds to the literature primarily on factors affecting behavioral intent to use technology in online learning.
Tujuan dari penelitian ini adalah untuk menganalisis faktor-faktor yang mempengaruhi niat perilaku guru menggunakan teknologi dalam pembelajaran online. Penelitian ini menggunakan pemodelan persamaan struktural dengan menggunakan pendekatan partial least square untuk menguji hipotesis. Berdasarkan purposive sampling, kuesioner disebarkan melalui survei online dan mendapat tanggapan dari 96 responden. Hasil penelitian menunjukkan bahwa variabel laten, ekspektasi kinerja, ekspektasi usaha, dan kondisi fasilitas memiliki hubungan positif dan signifikan dengan niat perilaku individu dalam penggunaan teknologi dalam pembelajaran online. Variabel laten “fasilitas kondisi” merupakan faktor yang paling berpengaruh. Penelitian ini memberikan gambaran dan pemahaman penting bagi pembuat kebijakan dalam merancang kerangka kerja untuk memperhatikan kondisi fasilitas. Penelitian lebih lanjut disarankan di masa depan mencakup sampel dari berbagai provinsi di Indonesia. Studi ini menambah literatur terutama pada faktor-faktor yang mempengaruhi niat perilaku untuk menggunakan teknologi dalam pembelajaran online.
Nanoparticle-Based Lateral Flow Biosensors Integrated With Loop-Mediated Isothermal Amplification for the Rapid and Visual Diagnosis of Hepatitis B Virus in Clinical Application
Authors: Chen Xu , Wang Shoshi , Tan Yan , Huang Junfei , Yang Xingui , Li Shijun 
Published: September 2021

Hepatitis B virus (HBV) infection remains one of the major public health issues worldwide. Developing a rapid, sensitive, specific, easy-to-operate, and cost-saving approach for the diagnosis of HBV is essential for its therapy and prevention. Here, we first devised a novel approach, termed “loop-mediated isothermal amplification integrated with a nanoparticle-based lateral flow biosensor (LAMP-LFB),” for the detection of HBV in clinical application. The results indicated that a set of LAMP primers based on the S gene were valid for the establishment of HBV-LAMP-LFB. The optimal HBV-LAMP can be carried out at a constant temperature of 65°C for 40 min. The whole detection process, including HBV genomic DNA preparation (∼10 min), LAMP (40 min), and LFB reading (within 2 min), can be accomplished within 60 min. The limit of detection of the HBV-LAMP-LFB assay was 7.5 IU per test. The specificity of this assay was one hundred percent, and there was no cross-reactivity with other pathogens. Hence, these results indicated that the HBV-LAMP-LFB assay established in the current study is a sensitive, rapid, specific, visual, simple, and cost-saving method for the screening of HBV agents. More importantly, the HBV-LAMP-LFB has remarkable potential to develop a point-of-care testing in clinical application, especially in resource-scarce regions.
Clinical Significance of CYFRA21-1, AFP, CA-153, CEA, and CA-199 in the Diagnosis of Lung Cancer Ocular Metastasis in Hypertension Population
Authors: Tang Jing , Ge Qian-Min , Huang Rong , Shu Hui-Ye , Su Ting , Wu Jie-Li , Pan Yi-Cong , Liang Rong-Bin , Zhang Li-Juan , Shao Yi , Yu Yao 
Published: September 2021

Purpose: To detect lung metastases, we conducted a retrospective study to improve patient prognosis.Methods: Hypertension patients with ocular metastases (OM group; n = 58) and without metastases (NM group; n = 1,217) were selected from individuals with lung cancer admitted to our hospital from April 2005 to October 2019. The clinical characteristics were compared by Student's t-test and chi-square test. Independent risk factors were identified by binary logistic regression, and their diagnostic value evaluated by receiver operating characteristic curve analysis.Results: Age and sex did not differ significantly between OM and NM groups; There were significant differences in pathological type and treatment. Adenocarcinoma was the main pathological type in the OM group (67.24%), while squamous cell carcinoma was the largest proportion (46.43%) in the NM group, followed by adenocarcinoma (34.10%). The OM group were treated with chemotherapy (55.17%), while the NM group received both chemotherapy (39.93%) and surgical treatment (37.06%). Significant differences were detected in the concentrations of cancer antigen (CA)−125, CA-199, CA-153, alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), cytokeratin fraction 21-1 (CYFRA21-1), total prostate-specific antigen, alkaline phosphatase, and hemoglobin (Student's t-test). Binary logistic regression analysis indicated that CA-199, CA-153, AFP, CEA, and CYRFA21-1 were independent risk factors for lung cancer metastasis. AFP (98.3%) and CEA (89.3%) exhibited the highest sensitivity and specificity, respectively, while CYRFA21-1 had the highest area under the ROC curve value (0.875), with sensitivity and specificity values of 77.6 and 87.0%, respectively. Hence, CYFRA21-1 had the best diagnostic value.
The Distribution of Cardiovascular-Related Comorbidities in Different Adult-Onset Cancers and Related Risk Factors: Analysis of 10 Year Retrospective Data
Authors: Li Qingsong , Liu Fei , Tang Yuqi , Lee Sharen , Lang Chao , Bai Lan , Xia Yunlong 
Published: September 2021

Introduction:Understanding the epidemiology of cardiovascular disease (CVD) related comorbidity is a key strategy for improving the outcomes of patients with cancer. Therefore, this study aimed to assess the distribution of cardiovascular comorbidities and cardiovascular risk factors (CVRF) among five cancer sites.Methods:This is a single-centered, cross-sectional study performed in Dalian, China. Between 2008 and 2018, all newly diagnosed cancer in the First Affiliated Hospital of Dalian Medical University, China were screened. Clinical data were extracted from a comprehensive electronic health record system.Results:35861 patients with lung, colorectal, gastric, breast, and thyroid cancer were collected retrospectively. The most prevalent CVDs in descending order were hypertension (21.9%), followed by coronary heart disease (6.5%), atrial fibrillation (2.9%), and heart failure (1%). The prevalence of hypertension significantly varies between lung (21.3%), colorectal (27.3%), gastric (22.5%), breast (16.7%), and thyroid cancer (22.4%) (P&lt; 0.001). CVRF varies with cancer sites. Age, sex, total cholesterol, triglyceride, low-density lipoprotein cholesterol, systolic blood pressure, smoking, alcohol use, and diabetes mellitus (DM) are common risk factors associated with CVD at different cancer sites. The association between DM and presence of CVD was strong in breast (odds ratio [OR] = 4.472, 95% confidence interval [CI]: 3.075–6.504,P&lt; 0.001), lung (OR = 3.943; 95% CI: 3.270–4.754,P&lt; 0.001), colorectal (OR = 3.049; 95% CI: 2.326–3.996,P&lt; 0.001), and gastric (OR = 2.508; 95% CI: 1.927–3.264,P&lt; 0.001) cancer.Conclusion:Cancer patients had a significant burden of CVD and increased CVRF. The prevalence of CVRF and CVD comorbidity differ for cancer types. DM remains significantly associated with CVD at different cancer sites except for thyroid cancer.
Exploring the Association Between Electronic Wearable Device Use and Levels of Physical Activity Among Individuals With Depression and Anxiety: A Population Level Study
Authors: Onyeaka Henry , Firth Joe , Enemuo Valentine , Muoghalu Chioma , Naslund John , Baiden Philip , Torous John 
Published: September 2021

Aim: The present study aimed to investigate the cross-sectional association between self-reported use of electronic wearable devices (EWDs) and the levels of physical activity among a representative sample of adults with depression and anxiety in the United States.Methods: For this cross-sectional study, data were pooled from the Health Information National Trends Survey 2019. A sample of 1,139 adults with self-reported depression and anxiety (60.9% women; mean age of 52.5 years) was analyzed. The levels of physical activity and prevalence of EWD utilization were self-reported. The chi-square tests were used to compare individual characteristics through the use of EWDs. Multivariable logistic regression was employed to investigate the association between EWDs and physical activity levels while adjusting for sociodemographic and health-related factors.Results: From the 1,139 adults with self-reported depression and anxiety, 261 (weighted percentage 28.1%) endorsed using EWD in the last year. After adjusting for covariates, the use of EWDs was only significantly associated with a higher odds of reporting intention to lose weight (OR 2.12; 95% CI 1.04, 4.35; p = 0.04). We found no association between the use of EWDs and meeting the national weekly recommendation for physical activity or resistance/strength exercise training.Conclusion: About three in 10 adults suffering from depression and anxiety in the United States reported using EWDs in the last year. The current study findings indicate that among people living with mental illness, EWD use is associated with higher odds of weight loss intent suggesting that EWDs may serve as an opening for the clinical interactions around physical health through identifying patients primed for behavior change. Further large-scale studies using randomized trial designs are needed to examine the causal relationships between EWDs and the physical activity of people with mental health conditions.
Late Jurassic Structural Deformation and Late Cenozoic Reactivation of the Southern Junggar Fold-And-Thrust Belt, NW China
Authors: Ma Delong , Yuan Jianying , Sun Yanpeng , Wang Hongbin , He Dengfa , Wang Yanjun , Pan Shuxin , Cui Jian 
Published: September 2021

Because of the influence of the far field effect of the collision between Euro-Asian and India plates during the Late Cenozoic, the Tian Shan orogenic belt underwent intense reactivation, forming the Southern Junggar fold-and-thrust belt (SJ-FTB) to the north and the Kuqa fold-and-thrust belt to the south. Most previous research focuses on the deformation features and mechanisms during the Late Cenozoic. However, little research has been done on deformation features and mechanisms during the Late Jurassic. In this paper, we conducted geometric and kinematic analyses of seismic profiles and outcrop data to reveal the Late Jurassic deformation characteristics in SJ-FTB. Furthermore, we carried out sandbox modeling experiments to reproduce the regional structural evolution since the Early Jurassic. Angular unconformity between the Cretaceous and Jurassic is well preserved in the Qigu anticline belt. This unconformity also exists in the Huoerguosi–Manasi–Tugulu (HMT) anticline belt, which is the second fold belt of the SJ-FTB, indicating that the HMT anticline belt started to become active during the Late Jurassic. The Qigu anticline belt reactivated intensively during the Late Cenozoic, and the displacement was transferred to the HMT anticline belt along the Paleogene Anjihaihe Formation mudstone detachment. Therefore, the present-day SJ-FTB forms because of the two-stage compressional deformation from both the Late Jurassic and Late Cenozoic (ca. 24 Ma).
Submarine Groundwater Discharge From Sediments and Sand Boils Quantified by the Mean Residence Time of a Tracer Injection
Authors: Schlüter Michael , Maier Philipp 
Published: September 2021

To quantify submarine groundwater discharge, we developed an inexpensive automated seepage meter that applies a tracer injection and the computation of the mean residence time. The SGD-MRT is designed to measure a wide range of discharge rates from about 30 to 800 cm³/min and allows minimizing backpressures caused by pipe friction or flow sensors. By modifying the inner volume of the flow-through unit, the range of measurement is adjustable to lower or higher discharge rates. For process control and data acquisition, an Arduino controller board is used. In addition, components like temperature, conductivity, and pressure sensors or pumps extend the scope of the seepage meter. During field tests in the Wadden Sea, covering tidal cycles, discharge rates of more than 700 cm³/min were released from sand boils. Based on the measured discharge rates and numerical integration of the time series data, a water volume of about 400 dm3 with a seawater content of less than 12% was released from the sand boil within 7 h.
Parents’ Perceptions of School Support During COVID-19: What Satisfies Parents?
Authors: Haller Teresa , Novita Shally 
Published: September 2021

During the COVID-19 pandemic lockdown, face-to-face schooling could not be performed continuously, and alternative ways of learning had to be organized. Parents had to act as their children’s home schooling tutors while working from home, and schools had to deal with various alternatives to distance education. Since parents are by all means both important school users and partners, their perceptions of schools can be considered a central indicator for assessing school quality. In this respect, during school lockdown, parents’ school satisfaction may reflect schools’ ability to adjust and react to fast social changes with almost no time for preparation. To date, there is nearly no knowledge about school satisfaction or school support during this challenging situation. Using data from the COVID-19 survey of the German National Educational Panel Study, we identified central predictors of parents’ perceptions of school support during the national lockdown in Germany in spring 2020. All students (N= 1,587;Mage= 14.20;SD= 0.36; 53% girls) and their parents (Mage= 47.36;SD= 4.99; 91% women) have participated in the longitudinal survey for at least 8 years. The results of the structural equation model indicate that the perceived support and abilities of teachers have been especially relevant for parents’ school satisfaction during the time of the school lockdown. In contrast, factors relating to parents’ and children’s backgrounds seem to be less important.
Surgical Outcome and Malignant Risk Factors in Patients With Thyroid Nodule Classified as Bethesda Category III
Authors: Huang Jianhao , Shi Hongyan , Song Muye , Liang Jinan , Zhang Zhiyuan , Chen Xiaohang , Liu Yongchen , Wang Sanming , Wu Zeyu 
Published: September 2021

BackgroundThyroid nodules are a very common finding in the general population. Fine-needle aspiration (FNA) has been recommended as the initial test for the evaluation of thyroid nodules. The trend on reporting as atypia of undetermined significance (AUS) has been significantly increased, but the malignant risk is still controversial among different studies. The aim of this study is to investigate the malignancy risk of thyroid nodules reported as Bethesda category III (AUS/FLUS) on initial FNA.MethodWe reviewed 272 papillary thyroid cancer (PTC) patients with suspicious thyroid nodules who underwent fine-needle aspiration and received surgical treatment during 2019 to 2020.ResultsOne hundred ten (40.4%) patients were diagnosed with PTC. Multivariate analysis showed that microcalcification (p = 0.037, OR = 2.260, 95% CI: 1.051–4.860), shape (p = 0.003, OR = 4.367, 95% CI: 1.629–11.705), diameters (p = 0.002, OR = 0.278, 95% CI: 0.123–0.631), anti-thyroglobulin antibodies (TGAb) (p = 0.002, OR = 0.150, 95% CI: 0.046–0.494), anti-thyroid peroxidase antibody (A-TPO) (p = 0.009, OR = 4.784, 95% CI: 1.486–15.401), and nodule goiter (p &lt; 0.001, OR = 0.100, 95% CI: 0.046–0.217) were independent malignant risk factors in patients with thyroid nodule classified as Bethesda category III.ConclusionIn this study, malignant risk factors in patients with thyroid nodule classified as Bethesda category III were significantly associated with preoperative serum TGAb, A-TPO, microcalcification, irregular shape, and nodule diameters. Nodules with malignant factors should be carefully elevated; surgery may be the better option for those patients.
Complement Activation Is Associated With Crescents in IgA Nephropathy
Authors: Wang Zi , Xie Xinfang , Li Jingyi , Zhang Xue , He Jiawei , Wang Manliu , Lv Jicheng , Zhang Hong 
Published: September 2021

IntroductionCrescents, especially those found at a percentage greater than 50%, are often associated with rapid progression of kidney disease in IgA nephropathy (IgAN). The mechanism of crescents forming in IgAN is still unclear. In this study, we aimed to evaluate whether excess complement activation participates in the formation of crescents in IgAN.MethodsOne hundred IgAN patients with various proportions of crescents—24 with 1%–24%, 27 with 25%–49%, 21 with 50%–74% 12 with more than 75%, and 16 without crescents—were included. Urinary concentrations of mannose-binding lectin (MBL), Bb, C4d, C3a, C5a, and soluble C5b-9 (sC5b-9) were measured at the time of biopsy. Receiver operating characteristic (ROC) curves were performed to evaluate predictive ability of renal survival for urine complement activation. In addition, historical C4d, C5b-9, and C3d were stained by immunohistochemistry.ResultsIgAN patients with more than 50% crescent formation showed higher complement activation levels than the other patients (urinary C3a/creatinine (C3a/Cr): 6.7295 ng/mg, interquartile range (IQR) 1.4652–62.1086 ng/mg vs. 0.1055 ng/mg, IQR 0–1.4089 ng/mg; urinary C5a/Cr: 15.6202 ng/mg, 4.3127–66.7347 ng/mg vs. 0.3280 ng/mg, IQR 0.0859–2.4439 ng/mg; urinary sC5b-9/Cr: 98.6357 ng/mg, 8.8058–1,087.4578 ng/mg vs. 1.4262 ng/mg, 0.0916–11.0858 ng/mg, all p-values &lt;0.001). The levels of urinary MBL and C4d representing lectin complement pathway showed a linear association with the proportion of crescents (r = 0.457 and 0.562, respectively, both p-values &lt;0.001). Combined urine complement products could increase the predictive ability compared with crescents alone from 0.904 to 0.944 (p = 0.062) with borderline significance. Moreover, the glomerular C4d deposition rate elevated with the increase of proportions of crescents.ConclusionExcess complement activation may be involved in the formation of crescents, especially diffuse crescent formation, in patients with IgAN. Urinary C4d correlated with the proportion of crescents and was a potential biomarker for disease monitoring in crescentic IgAN.