bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elucidating the Prognostic Role of BRAF V600E and the Activation Status of the Downstream MAPK Pathway in PTC: A Study from a Tertiary Centre in India
Authors: Kocheri Nadeem , Chatterjee Priti , Agarwal Shipra , Sharma Mehar C. , Ballal Sanjana , Bal Chandrasekhar , Chumber Sunil 
Published: December 2024

Abstract

Introduction:
Papillary thyroid carcinoma (PTC) has an excellent prognosis, but few cases are treatment-resistant. To check the applicability of combined BRAF
V600E and MEK-targeted therapy, the current study correlated BRAF
V600E with the MAPK pathway activation status in a cohort of PTCs. The prognostic relevance of BRAF
V600E and the usability of immunohistochemistry (IHC) for detecting the mutation were also assessed.

Methods:
Randomly selected 50 PTC and 15 non-PTC cases were re-classified according to the 2022 WHO classification. The BRAF mutation status was compared with the IHC of BRAFV600E, pERK1/2, pMEK1/2, and clinicopathological variables, including response to radioactive iodine and disease-free survival.

Results:

BRAF
V600E mutation was present in 38%. Most (87.8%) cases were immunopositive for pMEK1/2 and 40% for pMEK1/2. Although BRAF
V600E mutation did not correlate with the MAPK activation status, it had an adverse impact on tumour sensitivity to radioiodine (P < 0.05). Five of the seven radioiodine-resistant tumours were BRAF
V600E-mutated. An Allred cut-off score of 7 had a sensitivity of 100% and a specificity of 84% for detecting the mutation by IHC. All the non-PTC cases were BRAF-wild type, but 20% showed weak immunopositivity for mutated protein and were scored 6.

Conclusions:

BRAF
V600E-mutated PTCs are more likely to be RAI-resistant. MAPK pathway activation status did not vary significantly with BRAF mutation. Immunopositivity for pMEK1/2 in most suggests a scope for MEK1-targeted therapy in recalcitrant PTC cases even in the absence of the BRAF mutation. In addition, IHC is a reliable technique for detecting BRAF
V600E mutation but needs validation by correlation with molecular studies.
Effectiveness of Oral Semaglutide in Management of Type 2 Diabetes: A Real-World Study from India
Authors: Dutta Aditya , Mahendru Shama , Sharma Rutuja , Mithal Ambrish 
Published: December 2024

Abstract

Introduction:
Oral Semaglutide (Sema-o) is the first oral glucagon like peptide-1 receptor analogue (GLP-1RA) commercially available for the treatment of type 2 diabetes (T2D). This study aimed to evaluate the efficacy of Sema-o in patients with T2D when added to the existing therapy.

Methods:
This retrospective real-world study enrolled adult patients with diabetes taking Sema-o, with at least one follow-up (from February 2022 till October 2023). A proforma recorded baseline and follow-up date, medications, body composition, laboratory and clinical parameters. Data is presented as median (interquartile range) and was analysed using SPSS.

Results:
A total of 351 patients followed up once, while 56 patients had 4 follow-up visits. Baseline parameters were as follows: age 53 years (43–61), duration of diabetes 10 years (5–16), weight 91 kg (79–103), body mass index (BMI) 32.7 kg/m2 (29.3–36.6) and HbA1c 7.9% (6.9–9). The addition of Sema-o in the existing therapy for diabetes resulted in a significant reduction in HbA1c {follow-up: 1st 0.5%, 2nd 0.9%, 3rd 1.1% and 4th 1.1% (all, P < 0.001)} and % weight reduction {follow-up: 1st 2%, 2nd 3.3%, 3rd 4.1% and 4th 4.3% (all, P < 0.001)} from baseline. Reductions in BMI, glucose (fasting/post-prandial), lipids, liver enzymes and body composition parameters were significant. Gastro-intestinal side-effects (299 events in 52.4% of patients) were frequent. A total of 34/9.7% patients discontinued Sema-o.

Conclusion:
Intensification of existing therapy with Sema-o in obese patients with moderately uncontrolled diabetes proved to be an effective and relatively safe strategy. Achieving normoglycemia and reductions in weight, lipids and body fat/visceral fat with Sema-o may confer a much needed cardiometabolic benefit in these patients.
Use of selective laser capsulotomy for mature white cataracts: Initial experience in Indian eyes
Authors: Kelkar Jai A , Kelkar Aditya S , Packard Richard , Jain Harsh H , Kelkar Shreekant 
Published: December 2024

Purpose:
To report the initial experience of performing capsulotomy in eyes with mature white cataracts using selective laser capsulotomy (SLC) in Indian eyes.

Methods:
This was a prospective, noncomparative, open-label study. All adults presenting to our institution with mature cataracts whose pupils dilated >6 mm and who were willing for phacoemulsification were invited to participate. During surgery, after staining the anterior capsule with a proprietary trypan blue, the CAPSULaser device (Excel-Lens Inc, Los Gatos, CA, USA) was used to create a capsulotomy of size ranging from 5 to 5.5 mm and phacoemulsification was carried out. The primary outcome was the size, centration, and continuity of the capsulotomy edge at the end of the surgery. Secondary outcomes were the surgical time for capsulotomy, capsulotomy centration on the intraocular lens (IOL) at 3 months, and adverse effects.

Results:
Thirty eyes were studied of 30 patients who were recruited with a mean age of 66.4 ± 8.3 years, of which 17 (57%) were men. The intraoperative size of capsulotomy was the same as intended in all eyes and the edges were smooth. None of the eyes experienced any visible capsular tears or run out events; one had a capsular tag. The time for capsulotomy including capsular staining was 3 ± 0.23 min. All IOLs were well centered at 3 months with a capsulotomy size remaining the same. The endothelial cell count had dropped by 8% at 3 months post-op, and the vision improved significantly to 0.03 log of minimum angle of resolution. None of the eyes experienced any intraoperative complications or laser-induced adverse effects.

Conclusion:
SLC was a safe and effective technique providing precise, well-centered anterior capsulotomies in mature white cataracts.
Triple treatment therapy for congenital stromal iris cyst
Authors: Lomi Neiwete , Kumari Neha , Tandon Radhika 
Published: December 2024

Background:
Iris cyst can lead to iridocyclitis, angle closure, secondary glaucoma, corneal decompensation, band keratopathy, cataract, subluxation of the lens, or visual disturbance leading to amblyopia or strabismus. Incomplete removal of cyst can lead to recurrence. Recurrent surgeries are more complicated and compromise prognosis. So, complete removal of cyst with minimal anatomical disturbances is essential for better outcomes.

Purpose:
To define a new technique of triple treatment therapy for iris cyst management.

Synopsis:
Iris cyst was treated in three steps. In the first step, iris cyst aspiration followed by cyst cavity treatment with mitomycin-C was done. After that, cyst cavity was irrigated with balanced salt solution (BSS). In the second step, the anterior cyst wall was removed with a vitrectomy cutter. In the third step, the posterior cyst wall was cauterized with diathermy.

Highlights:
In this technique, we chose a minimally invasive approach utilizing two 1-mm incisions leading to less astigmatism. Iridectomy was not performed, which led to a small iris defect postoperatively, and pupilloplasty was not required. Injection of mitomycin-C led to destruction of the cyst wall, and diathermy further reduced the chance of recurrence by destroying the cyst base. Postoperatively, mild corneal edema was noted, which resolved in 1 week. Topical steroids were given to control postoperative inflammation. No recurrence has been noted till 6 months of follow-up. The more conservative approach seemed to result in better visual outcomes.

Discussion:
Wide varieties of approaches are available for iris cysts, like laser cystotomy, aspiration, diathermy, cryotherapy, injection of sclerosing agents, and surgery.[1] Yu et al.[2] treated iris cyst in a 60-year-old female with cyst content aspiration using 30G needle, followed by injection of 0.0002 mg/ml mitomycin-C in the cavity for 5 min. BSS wash was given five times at the end. They noted a decrease of 13.3% in endothelial cell count following the procedure. They speculate that transient application of MMC can cause permanent damage to the epithelial and goblet cells that secrete cyst fluid, hence resulting in regression of the cyst. Similarly, Kawaguchi et al.[3] aspirated cyst fluid with a 30G needle and left 0.3 ml of 10−3 mg/ml mitomycin-C for 5 min in the cavity, followed by BSS wash in a 32-year-old female with recurrent iris cyst. They reported a decrease of 4% in endothelial cell count postprocedure. Shen et al.[4] used micro diathermy to treat residual cyst wall attached to the endothelium and base of cyst in four cases. In our case, we have combined cyst aspiration, mitomycin-C, excision using vitrectomy cutter, and diathermy. No recurrence has been observed at the longest follow-up of 3 years. However, a small sample size and less duration of follow-up are the limitations to call it the best approach.

Video Link:

https://youtu.be/EC6WA2TiaAE
Playing with Fire at the Zaporizhzhia Nuclear Power Plant and the Challenges for International Nuclear Law in Central Europe
Authors: Novotná Marianna , Handrlica Jakub 
Published: December 2024

Since the start of the military aggression of the Russian Federation against Ukraine in February 2022, the Zaporizhzhia Nuclear Power Station has been at the centre of heavy combat. The Zaporizhzhia Nuclear Power Station, which is both the largest nuclear power plant in Europe and the tenth largest nuclear power plant in the world, has been targeted by various weapons, including rocket-propelled grenades and drones. The fact is that a potential nuclear accident in this installation may have tremendous transboundary impacts on the whole region of Central Europe. In this respect, the question arises of whether international law provides an appropriate reaction to these realities. Having outlined this question, one must bear in mind that since March 2022, the Ukrainian executive has lost effective control over the nuclear power plant, which has been controlled since then – in strict contradiction with the rules of international law - by the Russian Federation since then. This article analyses the potential applicability of three international agreements - the Convention on Early Notification of a Nuclear Accident, the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency and the Vienna Convention on Civil Liability for Nuclear Damage - and will respond to a potential accident in this nuclear power plant. This article is written from the perspective of the states of Central Europe, whose territories are most likely to be affected by a nuclear incident that occurred at the Zaporizhzhia Nuclear Power Station.
Optimización de espacios para calzadas urbanas en localidades pequeñas: caso sitio Sancán
Authors: Cobos Lucio Denny Augusto 
Published: December 2024

La optimización de espacios para calzadas vehiculares en localidades pequeñas como el sitio Sancán, busca mejorar la movilidad y calidad de vida de sus usuarios, este proceso implicó un reajuste de espacios para equilibrar el uso entre vehículos y peatones, promoviendo la seguridad vial y reducción del tiempo de traslado, además se busca garantizar la optimización funcional, integrando elementos como aceras y calzadas confortables. Se implementaron cambios con planificación de calles utilizando la metodología del Manual de Capacidad de Carreteras, incluyendo pasos peatonales, demarcación de carriles vehiculares, espacios de aparcamientos, estimulando el tránsito a pie y en bicicleta; también consideró la cercanía entre viviendas y servicios. La planificación vial urbana considera diversidades de usos del espacio para evitar la saturación en horas pico. Las calzadas vehiculares contribuyen a crear entornos urbanos sostenibles y accesibles, este enfoque mejora la movilidad y contribuye a un entorno urbano saludable y atractivo para los usuarios.
IMPLEMENTASI PROGRAM REHABILITASI RUMAH TIDAK LAYAK HUNI DI NEGERI RUMAH TIGA KOTA AMBON
Authors: Wabula Wa Firda , Soselisa Pieter Sammy , Pattimukay Hengky V.R. 
Published: December 2024

Salah satu Kota Ambon yang melaksanakan Program Rehabilitas Rumah Tidak Layak Huni adalah Kota Ambon Pemerintah Kota Ambon meluncurkan Program Rehabilitas Rumah Tidak Layak Huni berdasarkan Peraturan WaliKota Nomor: 12 Tahun 2018` Tentang Petunjuk Teknis Rehabilitasi Rumah Tidak Layak Huni dan Alasan Kota Ambon melaksanakan Program Rehabilitas Rumah Tidak Layak Huni adalah sebagai upaya untuk mengurangi tingkat kekumuhan, menanggulangi dan menurunkan angka kemiskinan. Penelitian ini bertujuan untuk mengetahui tingkat kesusaian dan standar Implementasi Rumah tidak Layak Huni di Negeri Rumah 3 .adapun teknik pengumpulan data yang dilakukan adalah obesrvasi dan wawancara. Hasil penelitian ini menunjukkan bahwa penerimaan bantuan program rumah tidak layak huni ini bermanfaat bagi masyarakat miskin untuk memenuhi kebutuhan tempat tingal yang layak untuk dihuni serta memberikan kesan semangat bagi masyarakat kurang mampu dalam kehidupan dan fungsi sosial.
Teknik Lateral Flow Assay LD-Bio Untuk Deteksi Antibodi Spesifik Aspergillus Spp. pada Pasien Terduga Aspergilosis Paru Kronik (APK)
Authors: Sofvina Winda , Prihartono Nurhayati Adnan 
Published: December 2024

Indonesia merupakan negara dengan beban Tuberkulosis (TB) paru yang tinggi. Tuberkulosis paru dapat dicegah dan diobati, namun pasien dengan TB paru tetap memiliki risiko untuk mengalami penyakit paru lain pasca pengobatan. Infeksi paru dapat terjadi, salah satunya adalah infeksi jamur Aspergillus dalam bentuk Aspergilosis Paru Kronik (APK). Dapat dikatakan bahwa beban APK akan sejalan dengan beban TB. Penegakkan diagnosis APK harus memenuhi kriteria klinis, radiologis, dan laboratorium. Kriteria laboratorium dapat berupa deteksi antibody dan atau kultur specimen saluran napas. Kriteria serologi yang diharapkan untuk diagnosis cepat adalah alat diagnostic dengan biaya terjangkau, metode kerja yang sederhana dan dapat diaplikasikan pada area dengan sumber daya terbatas. Studi literatur ini membahas akurasi teknik Lateral Flow Assay (LFA) LdBio sebagai alternatif untuk deteksi antibodi Aspergillus. Pada studi ini ditemukan bahwa berbagai penelitian melaporkan sensitivitas dan spesifisitas LFA Ldbio cukup tinggi.
Pengaruh Tourism Experience Economy, Tourist Engagement & Overall Satisfaction Dalam Menciptakan Intensi Berbagi Word Of Mouth (WOM) Wisatawan Mancanegara di Desa Wisata Pinge, Kabupaten Tabanan, Provinsi Bali
Authors: Darmateja I Made Sugita 
Published: December 2024

Penelitian ini ditujukan untuk menganalisa pengaruh dari tourism experience economy, tourist engagement dan overall satisfaction dalam menciptakan intensi prilaku berbagi word of mouth (WOM) wisatawan mancanegara di Desa Wisata Pinge, Bali dengan mengaplikasikan konstruk model hirarki.. Data dari 143 sampel responden dikumpukan pada periode waktu penelitian Agustus hingga Desember 2023 untuk digunakan dalam analisa hubungan kausal. Di dalam model penelitian ini, tourism experience economy dan tourist engagement diposisikan sebagai konstruk second order yang secara teori memiliki pengaruh pada overall satisfaction sebagai anteseden dari penciptaan intensi berbagi word of mouth (WOM). Dalam analisa model struktural, hasil yang ditemukan adalah konstruk tourism experience economy secara signifikan berpengaruh pada overall satisfaction dengan nilai koefisien 0,670; dan kepuasan menyeluruh wisatawan secara signifikan berpengaruh positif juga pada intensi wisatawan mancanegara untuk berbagi word of mouth (WOM) di Desa Wisata Pinge dengan nilai koefisien jalur sebesar 0,580..
Perluasan Kompetensi Pengadilan Tata Usaha Negara dalam Mengadili Tindakan Faktual Pemerintah
Authors: Penu Stephanie Angela , Likadja Jeffry A. Ch. , Helan Yohanes G. Tuba 
Published: December 2024

Keputusan dan ketetapan sebagai instrumen hukum pemerintah dalam melakukan tindakan hukum sepihak, dapat menjadi penyebab terjadinya pelanggaran hukum bagi warga negara, dalam Undang-Undang Nomor 5 Tahun 1986 tentang Peradilan Tata Usaha Negara dan perubahannya, dalam undang-undang tersebut dijelaskan yang menjadi objek sengketa tata usaha negara ialah yang berisi tindakan hukum yang dapat menimbulkan akibat hukum bagi seseorang atau badan hukum perdata, setidaknya ada kemudahan bagi masyarakat untuk menggugat pemerintah dan meminta pembatalan keputusan yang telah dibuat oleh pemerintah, namun karena adanya perluasan objek tersebut yang dimana pada Undang-Undang Nomor 30 Tahun 2014 Pasal 87 huruf (a) mencantumkan penetapan tertulis, mencakup tindakan faktual. Oleh karena itu perumusan masalah dalam penelitian ini adalah apakah pengadilan tata usaha negara berkompeten mengadili tindakan faktual pemerintah yang merugikan masyarakat, bagaimana perlindungan hukum bagi masyarakat yang dirugikan oleh tindakan faktual pemerintah. Penelitian ini merupakan penelitian hukum normatif dengan pendekatan undang-undang, konseptual, historis serta doktridal yang berlaku untuk mengetahui keseluruhan peraturan hukum. Hasil penelitian menunjukan bahwa Perluasan kompetensi Pengadilan Tata Usaha Negara untuk mengadili tindakan faktual pemerintah tidak berkompetensi sebab tidak dapat menimbulkan akibat hukum karena tidak sejalan dan bertentangan sebagaimana diatur dalam Undang-Undang Nomor 5 Tahun 1986 tentang Peradilan TUN dan Perubahannya, masyarakat tidak mendapat perlindungan hukum melalui pengadilan tata usaha negara sebagai akibat tindakan faktual dari badan/pejabat TUN. Saran dari penelitian ini yaitu seharusnya tindakan faktual di hapus atau dihilangkan dari kompetensi pengadilan tata usaha negara dan tidak perlu ada lagi perluasan objek sengketa TUN, bagi masyarakat yang merasa dirugikan sebagai akibat dari tindakan faktual badan/pejabat TUN, seharusnya melakukan gugatan perbuatan melawan hukum ke pengadilan negeri.
Women, Islamic Education, and Socioeconomics for the Sustainable Development Goals (Sdgs): A Bibliometric Study of Understanding from 1880 to 2024
Authors: Muthoifin  , Khondoker Saif Uddin Ahmed , Mahmudulhassan  , Waston  , Nirwana Andri , Ardiansyah  , Dani Akhmad Anwar 
Published: December 2024

Objective: The objective of this research is to examine the relationship between Islamic education, female literacy, and socioeconomic conditions from 1880 to 2024 through a bibliometric analysis to map the academic landscape, pinpoint important publications, noteworthy authors, important trends, and topic clusters, and offer suggestions for future lines of inquiry.

Theoretical Framework: To comprehend the development and present status of research, the study integrates document and network assessment using bibliometric analysis. It is based on theories of socioeconomic development, gender studies, and educational sociology, especially as they relate to Islamic contexts.

Method: Employing information from a Boolean query on the Scopus database, a quantitative method is used. R/R-Studio, VOSviewer, and Microsoft Excel are examples of analysis tools. The analysis looks at major publications, prominent writers, theme clusters, geographical spread, and important trends.

Results and Discussion: Prominent journals, high-impact publications, and significant contributors are evident from the results. Substantial contributions from Malaysia, the US, and Indonesia-related subjects include female literacy, socioeconomics, and education. Offering insights into policy and educational practices, the debate emphasizes the multidisciplinary aspect of the research and the significance of Islamic education in influencing female literacy and socioeconomic results.

Research Implications: The research points up gaps in the literature and recommends topics for more investigation. Researchers and policymakers can use the analysis's insights to help advance female literacy and socioeconomic development within Islamic schools.

Originality/Value: Employing a rigorous and historical methodological approach, this study offers a comprehensive assessment of the current status of research in this field. It provides distinctive perspectives and is an invaluable tool for scholars, instructors, and decision-makers.
Analyzing Emotional Responses of Readers to Ian Mcewan's Atonement: Insights from a Case Study on Wechat Reading Platform
Authors: Wen Nie , Abai Dayang Shobihah Abang , Chan Siaw Leng , Isa Nur Ayuni Mohd 
Published: December 2024

Objective: This study investigates readers’ emotional responses to Ian McEwan’s Atonement to identify readers’ emotional experiences and emotional states when accepting this novel in a lifelong learning context.

Theoretical perspective: Taking a perspective of reader-response criticism, the study reveals readers’ emotional experiences and emotional states in reading Ian McEwan’s Atonement by exploring their literary critical discourses.

Method: Through a qualitative approach that applies thematic analysis, the study gathers 138 book reviews from the WeChat Reading Platform and analyzed the data using Nvivo.

Results and Discussion: It is noteworthy that this novel leaves readers with strong emotional feelings of sadness, regret, heart-wrenching and anger, etc., while at the same time, it receives a high recommendation rate of 80.7%, revealing inclusive quality reading for readers of literary works.

Research Implications: This research not only provides insights into how to further reader reception and reader response in literary studies in the context of lifelong learning but also offers valuable recommendations for advancing the studies of digital humanities and trans-cultural translation.
Strategy Model for Detecting Potential Fraudulent Financial Statements of State-Owned Enterprises in Indonesia: Fraud Heptagon Theory Analysis with Big Data Analytics, Risk Management, and Sustainable Development Goals (SDGS)
Authors: Achmad Tarmizi , Huang Chen-Yuan , Putra Mukhlas Adi , Pamungkas Imang Dapit 
Published: December 2024

Objective: Fraudulent financial statements are among the least frequent types of fraud globally but result in the highest median losses for companies. This study aims to develop a strategy model for detecting potential fraudulent financial statements in Indonesia’s State-Owned Enterprises (B.U.M.N.) by analyzing the Fraud Heptagon Theory, which includes stimulus, ability, collusion, opportunity, rationalization, ego, and big data analytics.

Theoretical Framework: The study incorporates risk management and the audit committee as moderating variables to evaluate their roles in mitigating fraudulent financial reporting. Fraudulent financial statements were measured using the F-Score Model, emphasizing Goal 16 of the Sustainable Development Goals (SDGs): Peace, Justice, and Strong Institutions.

Method: A total of 126 samples from 2018–2022 were obtained through purposive sampling. Data analysis employed Warp PLS 7.0 with a Structural Equation Modeling (SEM-PLS) approach.

Results and Discussion: The findings reveal that most Fraud Heptagon Theory elements do not significantly affect fraudulent financial statements, except for financial pressure, which acts as a stimulus proxy. While big data analytics enhances risk management, it does not directly mitigate fraudulent reporting. The audit committee moderates the collusion relationship with fraudulent financial reporting, albeit with limited overall impact.

Research Implications: This study offers a framework for stakeholders to leverage innovative technologies and governance strategies to improve financial transparency and accountability, aligning corporate practices with SDGs.

Originality/Value: This research integrates the Fraud Heptagon Theory with big data analytics and SDGs, proposing a novel strategy model for detecting fraudulent financial statements in State-Owned Enterprises. It highlights the dynamic role of advanced technologies and governance in fraud detection.