bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volatile Anästhetika zur präklinischen Analgesie durch Rettungssanitäter – Eine Übersicht
Authors: Trimmel Helmut , Egger Alexander , Doppler Reinhard , Beywinkler Christoph , Voelckel Wolfgang G. , Kreutziger Janett 
Published: October 2021

ZusammenfassungPatienten mit Schmerzen können durch den nichtärztlichen Rettungsdienst mitunter nur inadäquat versorgt werden, da aufgrund rechtlicher Einschränkungen die Anwendung stark wirksamer Schmerzmittel (Opioide) bzw. ausbildungsbedingt eine i.v.-Therapie in Deutschland und Österreich oft nicht möglich ist. Häufig müssen Notärzte für schmerzgeplagte Patienten nachgefordert werden, wodurch deren Verfügbarkeit für z. B. vitale Notfälle reduziert sein kann. Inhalativ zu verabreichende Analgetika könnten hierfür eine interessante Alternative darstellen.Derzeit steht dazu in Deutschland und Österreich Lachgas (N2O, als Livopan® im Handel) zur Verfügung, eine Mischung aus jeweils 50 % Lachgas und Sauerstoff. In Österreich ist seit 2018 auch Methoxyfluran (Penthrop®) zur Behandlung mäßiger bis starker Schmerzen nach einem Trauma für die prä- und innerklinische Anwendung bei Erwachsenen zugelassen.In der Zusammenschau der vorhandenen Literatur, jahrzehntelanger Erfahrung in der Anwendung der Sauerstoff-Lachgas-Mischung im angloamerikanischen Bereich und von inhalativem Methoxyfluran v. a. in Australien sowie aktuellen Studien aus Europa kann gefolgert werden, dass diese bei Einhaltung der Anwendungsvorschriften effektiv, sicher und nebenwirkungsarm sind. Dies bestätigt auch eine eigene Untersuchung zu Methoxyfluran im präklinischen Einsatz. Die Anwendung von Lachgas ist aufgrund des Druckgaszylinders von der Handhabung her etwas aufwendig; Methoxyfluran ist einfacher anzuwenden und bei starken Schmerzen auch wirksamer. Die Zulassung von Methoxyfluran ist jedoch auf Erwachsene beschränkt, wo es mit zunehmendem Alter deutlich besser wirkt. Der Einsatz von Lachgas und insbesondere Methoxyfluran könnte aufgrund der Datenlage wie auch eigener Erfahrungen für rettungsdienstliches Fachpersonal nach entsprechender Einweisung empfohlen werden.
The influences of the variable speed and internal die geometry on the performance of two commercial soluble oils in the drawing process of pure copper fine wire
Authors: Martínez Gustavo Aristides Santana , Rodriguez-Alabanda Oscar , Prisco Umberto , Tintelecan Marius , Kabayama Leonardo Kyo 
Published: October 2021

AbstractThe cold wiredrawing process constitutes a classical-tribological system in which a stationary tribe-element (die) is in contact with a tribe-element in relative motion (wire) and both interacting with the interfacial tribe-element (lubricant). This condition is reflected in the effect of friction as a function of the drawing speed and temperature, and directly affects the wearing of the surface into the die and the final quality on the drawn wire. The aim of this work has been to determine the best conditions to process ETP-copper using two different types of oil/water emulsion lubricants. For this purpose, six different die geometries have been proposed and a set of tests have been carried out at different speeds (between 1 and 21 m/s) to determine those combinations that give a lower value in the required drawing force (Fd). The experiments allowed to know the friction coefficient (µ), the temperature profile inside the drawing die and in the lubricant and also the mean roughness (Ra) in the drawn product. The results have shown that drawing speeds above 10 m/s significantly decrease the drawing force and, as a consequence, the friction effect on the interface. The best results have been achieved in the combinations of the lower die angle (2β = 14°) with drawing speeds between 17 and 18 m/s with both types of lubricants used, obtaining the lower values of the friction coefficient between µ = 0.10–0.15 with the lubricant type D (Agip S234-60 oil at 7% concentration). It has been found that those tests carried out with dies with a smaller approach angle have generally made it possible to obtain better qualities in the final product. Additionally, FEM simulations have been done to analyse those cases with the lower values of µ, throwing values of Fd that are consistent with those measured in the experimental setting and allowing to better understand the behavior of the material as it passes through the die.
Midterm outcome and strength assessment after proximal rectus femoris refixation in athletes
Authors: Hinz Maximilian , Geyer Stephanie , Winden Felix , Braunsperger Alexander , Kreuzpointner Florian , Kleim Benjamin D. , Imhoff Andreas B. , Mehl Julian 
Published: October 2021

AbstractPurposeProximal rectus femoris avulsions (PRFA) are relatively rare injuries that occur predominantly among young soccer players. The aim of this study was to evaluate midterm postoperative results including strength potential via standardized strength measurements after proximal rectus femoris tendon refixation. It was hypothesized that the majority of competitive athletes return to competition (RTC) after refixation of the rectus femoris tendon without significant strength or functional deficits compared to the contralateral side.MethodsPatients with an acute (< 6 weeks) PRFA who underwent surgical refixation between 2012 and 2019 with a minimum follow-up of 12 months were evaluated. The outcome measures compiled were the median Tegner Activity Scale (TAS) and mean RTC time frames, Harris Hip Score (HHS), Hip and Groin Outcome Score (HAGOS) subscales, International Hip Outcome Tool-33 (iHOT-33), and Visual Analog Scale (VAS) for pain. In addition, a standardized isometric strength assessment of knee flexion, knee extension, and hip flexion was performed to evaluate the functional result of the injured limb in comparison to the uninjured side.ResultsOut of 20 patients, 16 (80%) patients were available for final assessment at a mean follow-up of 44.8 ± SD 28.9 months. All patients were male with 87.5% sustaining injuries while playing soccer. The average time interval between trauma and surgery was 18.4 ± 8.5 days. RTC was possible for 14 out of 15 previously competitive athletes (93.3%) at a mean 10.5 ± 3.4 months after trauma. Patients achieved a high level of activity postoperatively with a median (interquartile range) TAS of 9 (7–9) and reported good to excellent outcome scores (HHS: 100 (96–100); HAGOS: symptoms 94.6 (89.3–100), pain 97.5 (92.5–100), function in daily living 100 (95–100), function in sport and recreation 98.4 (87.5–100), participation in physical activities 100 (87.5–100), quality of life 83.1 ± 15.6; iHot-33: 95.1 (81.6–99.8)). No postoperative complications were reported. Range of motion, isometric knee flexion and extension, as well as hip flexion strength levels were not statistically different between the affected and contralateral legs. The majority of patients were “very satisfied” (56.3%) or “satisfied” (37.5%) with the postoperative result and reported little pain (VAS 0 (0–0.5)).ConclusionSurgical treatment of acute PRFA yields excellent postoperative results in a young and highly active cohort. Hip flexion and knee extension strength was restored fully without major surgical complications.Level of evidenceRetrospective cohort study; III.
Genipin-crosslinked chitosan/alginate/alumina nanocomposite gels for 3D bioprinting
Authors: Condi Mainardi Jessica , Rezwan Kurosch , Maas Michael 
Published: October 2021

AbstractImmobilizing microorganisms inside 3D printed semi-permeable substrates can be desirable for biotechnological processes since it simplifies product separation and purification, reducing costs, and processing time. To this end, we developed a strategy for synthesizing a feedstock suitable for 3D bioprinting of mechanically rigid and insoluble materials with embedded living bacteria. The processing route is based on a highly particle-filled alumina/chitosan nanocomposite gel which is reinforced by (a) electrostatic interactions with alginate and (b) covalent binding between the chitosan molecules with the mild gelation agent genipin. To analyze network formation and material properties, we characterized the rheological properties and printability of the feedstock gel. Stability measurements showed that the genipin-crosslinked chitosan/alginate/alumina gels did not dissolve in PBS, NaOH, or HCl after 60 days of incubation. Alginate-containing gels also showed less swelling in water than gels without alginate. Furthermore, E. coli bacteria were embedded in the nanocomposites and we analyzed the influence of the individual bioink components as well as of the printing process on bacterial viability. Here, the addition of alginate was necessary to maintain the effective viability of the embedded bacteria, while samples without alginate showed no bacterial viability. The experimental results demonstrate the potential of this approach for producing macroscopic bioactive materials with complex 3D geometries as a platform for novel applications in bioprocessing.
Total synthesis of the isoquinolinium metabolite ETM-204 of Trabectidin
Authors: Lembacher-Fadum Christian , Gissing Simon , Pour Georg , Breinbauer Rolf 
Published: October 2021

AbstractEcteinascidin-743 (Trabectidin, Trabectedin®, Yondelis®) is a synthetically obtained pharmaceutical drug originally isolated from a marine tunicate. Trabectedin is used for the chemotherapy of soft-tissue sarcoma and ovarian cancer. The isoquinolinium metabolite ETM-204 has been found in biotransformation and degradation studies of Trabectedin. We report the first total synthesis of ETM-204 and its full spectroscopic characterization confirming the postulated structure. Central elements of the 12-step synthesis starting from 2-methyl-6-nitrophenol are a Cu-mediated conversion of an iodoarene to a phenol, a Skattebøl-formylation, and a modified Pomeranz–Fritsch cyclization to assemble the isoquinoline ring. The pH-dependence of its visual absorbance could be clarified.
Graphic abstract
Spigelian hernia: current approaches to surgical treatment—a review
Authors: Hanzalova I. , Schäfer M. , Demartines N. , Clerc D. 
Published: October 2021

Abstract
Background
Spigelian hernias (SpH) belong to the group of eponymous abdominal wall hernias. Major reasons for diagnostic difficulties are its low incidence reaching maximum 2% of abdominal wall hernias, a specific anatomical localization with intact external oblique aponeurosis covering the hernia sac and non-constant clinical presentation.

Methods
A literature review was completed to summarize current knowledge on surgical treatment options and results.

Results
SpH presents a high incarceration risk and therefore should be operated upon even if the patient is asymptomatic. Both laparoscopic and open repair approaches are validated by current guidelines with lesser postoperative complications and shorter hospital stay in favour of minimally invasive surgery, regardless of the technique used. Overall recurrence rate is very low.

Conclusion
All diagnosed SpH should be planned for elective operation to prevent strangulated hernia and, therefore emergency surgery. Both open and laparoscopic SpH treatment can be safely performed, depending on surgeon’s experience. In most cases, a mesh repair is generally advised.
Wigner-function-based solution schemes for electromagnetic wave beams in fluctuating media
Authors: Weber Hannes , Maj Omar , Poli Emanuele 
Published: October 2021

AbstractElectromagnetic waves are described by Maxwell’s equations together with the constitutive equation of the considered medium. The latter equation in general may introduce complicated operators. As an example, for electron cyclotron (EC) waves in a hot plasma, an integral operator is present. Moreover, the wavelength and computational domain may differ by orders of magnitude making a direct numerical solution unfeasible, with the available numerical techniques. On the other hand, given the scale separation between the free-space wavelength $$\lambda _0$$

λ
0

and the scale L of the medium inhomogeneity, an asymptotic solution for a wave beam can be constructed in the limit $$\kappa = 2\pi L / \lambda _0 \rightarrow \infty$$

κ
=
2
π
L
/

λ
0

→
∞

, which is referred to as the semiclassical limit. One example is the paraxial Wentzel-Kramer-Brillouin (pWKB) approximation. However, the semiclassical limit of the wave field may be inaccurate when random short-scale fluctuations of the medium are present. A phase-space description based on the statistically averaged Wigner function may solve this problem. The Wigner function in the semiclassical limit is determined by the wave kinetic equation (WKE), derived from Maxwell’s equations. We present a paraxial expansion of the Wigner function around the central ray and derive a set of ordinary differential equations (phase-space beam-tracing equations) for the Gaussian beam width along the central ray trajectory.
Continuous Labor Support and Person-Centered Maternity Care: A Cross-Sectional Study with Women in Rural Kenya
Authors: Kiti Gift , Prata Ndola , Afulani Patience A. 
Published: October 2021

Abstract
Objective
This study assessed whether having continuous support during labor is associated with better person-centered maternity care (PCMC) among women in rural Kenya.

Methods
Data are from a cross-sectional survey with women aged 15–49 years who delivered in the 9 weeks preceding survey completion (N = 865). PCMC was operationalized using a validated 13-item scale, with a summative score developed from responses that capture dignity and respect, communication and autonomy, and supportive care from providers (excluding support from a lay companion). Continuous support was operationalized as the continuous presence of a lay companion (friend or family) during labor. We carried out bivariate analyses using chi-squared and t-tests and ran multivariable linear regression models to examine the association between continuous labor support and PCMC.

Results
The average PCMC score was 24.2 (SD = 8.4) out of a total score of 39. About two-thirds (68%) of women had continuous support during labor. The average PCMC scores among women who had continuous support was 25.7 (SD = 8.4) compared to 21.0 (SD = 7.6) among those who did not have continuous support (p-value ≤ 0.001). After controlling for various confounders this association was still significant (coefficient = 4.0; 95% CI 2.9, 5.2; p-value ≤ 0.001).

Conclusions
Women who have continuous labor support during childbirth are more likely to have improved PCMC. Efforts to promote PCMC should thus include continuous labor support.
The role of carbonic anhydrase III and autophagy in type 2 diabetes with cardio-cerebrovascular disease
Authors: Zhang Xiao-Ming , Tao Ying-Hong , Zhou Xiu-Ling , Shang Xi-Liang , Gong Xiao-Bo , Liu Ying-Chao , Huang Yan-Yan , Chen Gang , Yu Zhong-Yu , Wang Jian-Tao , Du Zun-Guo , Wu Guo-Feng , Zhang Yu , Guo Jing-Chun , Zhou Hou-Guang 
Published: October 2021

AbstractType 2 diabetes mellitus (T2DM) is one of the most common chronic diseases among the elderly people. The T2DM increases the risk of cardio-cerebrovascular disease (CCD), and the main pathological change of the CCD is atherosclerosis (AS). Meanwhile, the carbonic anhydrases (CAs) are involved in the formation and progression of plaques in AS. However, the exact physiological mechanism of carbonic anhydrase III (CAIII) has not been clear yet, and there are also no correlation study between CAIII protein and T2DM with CCD. The 8-week old diabetic mice (db/db−/− mice) and wild-type mice (wt mice) were feed by a normal diet till 32 weeks, and detected the carotid artery vascular opening angle using the method of biomechanics; The changes of cerebral cortex and myocardium were watched by the ultrastructure, and the autophagy were observed by electron microscope; The tissue structure, inflammation and cell injury were observed by Hematoxylin and eosin (HE) staining; The apoptosis of cells were observed by TUNEL staining; The protein levels of CAIII, IL-17, p53 were detected by immunohistochemical and Western Blot, and the Beclin-1, LC3, NF-κB were detected by Western Blot. All statistical analysis is performed using PRISM software. Compared with wt mice, db/db−/− mice’ carotid artery open angle increased significantly. Electron microscope results indicated that autophagy in db/db−/− mice cerebral cortex and heart tissue decreased and intracellular organelle ultrastructure were damaged. HE staining indicated that, db/db−/− mice’ cerebral cortex and heart tissue stained lighter, inflammatory cells infiltration, cell edema were obvious, myocardial fibers were disorder, and myocardial cells showed different degrees of degeneration. Compared with wt mice, TUNEL staining showed that there was obviously increase in db/db−/− mice cortex and heart tissue cell apoptosis. The results of immunohistochemistry and Western Blot indicated that CAIII, Beclin-1 and LC3II/I expression levels conspicuously decreased in cortex and heart tissue of db/db−/− mice, and the expression level of IL-17, NF-κB and p53 obviously increased. The carotid artery’ vascular stiffness was increased and which was probably related with formation of AS in diabetic mice. And the autophagy participated in the occurrence and development of diabetic CCD. CAIII protein might somehow be involved in the regulation of autophagy probably through affecting cell apoptosis and inflammation, but the underlying mechanism remains to be further studied.
SynergyGrids: blockchain-supported distributed microgrid energy trading
Authors: Aloqaily Moayad , Bouachir Ouns , Özkasap Öznur , Ali Faizan Safdar 
Published: October 2021

AbstractGrowing intelligent cities is witnessing an increasing amount of local energy generation through renewable energy resources. Energy trade among the local energy generators (aka prosumers) and consumers can reduce the energy consumption cost and also reduce the dependency on conventional energy resources, not to mention the environmental, economic, and societal benefits. However, these local energy sources might not be enough to fulfill energy consumption demands. A hybrid approach, where consumers can buy energy from both prosumers (that generate energy) and also from prosumer of other locations, is essential. A centralized system can be used to manage this energy trading that faces several security issues and increase centralized development cost. In this paper, a hybrid energy trading system coupled with a smart contract named SynergyGrids has been proposed as a solution, that reduces the average cost of energy and load over the utility grids. To the best of our knowledge, this work is the first attempt to create a hybrid energy trading platform over the smart contract for energy demand prediction. An hourly energy data set has been utilized for testing and validation purposes. The trading system shows 17.8% decrease in energy cost for consumers and 76.4% decrease in load over utility grids when compared with its counterparts.
The fundamental constants of physics and the International System of Units
Authors: Wiersma Diederik Sybolt , Mana Giovanni 
Published: October 2021

AbstractAir Canada managed to have a passenger aircraft run out of fuel in mid-air due to confusion about metric units (Stephenson in Mars climate orbiter mishap investigation board phase I report, NASA, 1999), and NASA lost an entire spacecraft due to a misunderstanding amongst engineers about the units used in the propulsion system design (Witkin in Jet’s fuel ran out after metric conversion errors, The New York Times, 1983). Measurements only make sense if the units are correct and well-defined. A unit of measurement is a definite magnitude of a quantity, defined by convention or law. Any other quantity of that kind can then be expressed as a multiple or submultiple of the unit of measurement. The Egyptians used the Farao as definite magnitude, while many years later, the french revolutionists introduced the earth as a reference and laid the foundations for the modern decimal system. Since recently, we have a truly universal and stable system that uses physics’s natural constants and laws to define the base units of measurement. This paper explains how this new concept works and how it is implemented in practice.
Applications of Uncrewed Aerial Vehicles (UAV) Technology to Support Integrated Coastal Zone Management and the UN Sustainable Development Goals at the Coast
Authors: Kandrot Sarah , Hayes Samuel , Holloway Paul 
Published: October 2021

AbstractData and information obtained from low-cost uncrewed aerial vehicles (UAVs), commonly referred to as ‘drones’, can be used to support integrated coastal zone management (ICZM) and sustainable development at the coast. Several recent studies in various disciplines, including ecology, engineering, and several branches of physical and human geography, describe the applications of UAV technology with practical coastal management potential, yet the extent to which such data can contribute to these activities remains underexplored. The main objective of this paper is to collate this knowledge to highlight the areas in which UAV technology can contribute to ICZM and can influence the achievement of the UN Sustainable Development Goals (SDGs) at the coast. We focus on applications with practical potential for coastal management activities and assess their accessibility in terms of cost, ease of use, and maturity. We identified ten (out of the 17) SDGs to which UAVs can contribute data and information. Examples of applications include surveillance of illegal fishing and aquaculture activities, seaweed resource assessments, cost-estimation of post-storm damages, and documentation of natural and cultural heritage sites under threat from, for example, erosion and sea-level rise. An awareness of how UAVs can contribute to ICZM, as well as the limitations of the technology, can help coastal practitioners to evaluate their options for future management activities.
Innovative strategies in metastatic gastric cancer: a short review
Authors: Puhr Hannah Christina , Ilhan-Mutlu Aysegul 
Published: October 2021

SummaryRecent innovative advances, especially concerning immunotherapeutic agents and targeted therapies, have changed the face of modern oncology. The year 2020 represents a milestone in the treatment of gastroesophageal cancer because several trials showed promising survival benefits, at least for a specific subgroup of patients. Not only immunotherapeutic agents, but also targeted therapies seem to be beneficial, particularly when the target is well defined and the threshold value is selected appropriately. Thus, many new innovative treatment strategies are underway and might lead to a further paradigm change in the therapy of patients with advanced gastric tumors. This review gives a concise overview of these new therapeutic options and recently approved strategies as well as ongoing studies.
Site-selective and metal-free C–H nitration of biologically relevant N-heterocycles
Authors: Moon Junghyea , Ji Hyun Ku , Ko Nayoung , Oh Harin , Park Min Seo , Kim Suho , Ghosh Prithwish , Mishra Neeraj Kumar , Kim In Su 
Published: October 2021

AbstractThe site-selective and metal-free C–H nitration reaction of quinoxalinones and pyrazinones as biologically important N-heterocycles with t-butyl nitrite is described. A wide range of quinoxalinones were efficiently applied in this transformation, providing C7-nitrated quinoxalinones without undergoing C3-nitration. From the view of mechanistic point, the radical addition reaction exclusively occurred at the electron-rich aromatic region beyond electron-deficient N-heterocycle ring. This is a first report on the C7–H functionalization of quinoxalinones under metal-free conditions. In contrast, the nitration reaction readily takes place at the C3-position of pyrazinones. This transformation is characterized by the scale-up compatibility, mild reaction conditions, and excellent functional group tolerance. The applicability of the developed method is showcased by the selective reduction of NO2 functionality on the C7-nitrated quinoxalinone product, providing aniline derivatives. Combined mechanistic investigations aided the elucidation of a plausible reaction mechanism.