bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Outcomes in Real Life of Lumacaftor–Ivacaftor Treatment in Adolescents With Cystic Fibrosis
Authors: Bui Stéphanie , Masson Alexandra , Enaud Raphaël , Roditis Léa , Dournes Gaël , Galode François , Collet Cyrielle , Mas Emmanuel , Languepin Jeanne , Fayon Michael , Beaufils Fabien , Mittaine Marie 
Published: November 2021

Background: The combination of the CFTR corrector lumacaftor (LUM) and potentiator ivacaftor (IVA) has been labeled in France since 2015 for F508del homozygote cystic fibrosis (CF) patients over 12 years. In this real-life study, we aimed (i) to compare the changes in lung function, clinical (e.g., body mass index and pulmonary exacerbations) and radiological parameters, and in sweat chloride concentration before and after initiation of LUM/IVA treatment; (ii) to identify factors associated with response to treatment; and (iii) to assess the tolerance to treatment.Materials and Methods: In this tri-center, non-interventional, and observational cohort study, children (12–18 years old) were assessed prospectively during the 2 years of therapy, and retrospectively during the 2 years preceding treatment. Data collected and analyzed for the study were exclusively extracted from the medical electronic system records of the patients.Results: Forty adolescents aged 12.0–17.4 years at LUM/IVA initiation were included. The lung function decreased significantly during and prior to treatment and increased after LUM/IVA initiation, becoming significant after 2 years of treatment. LUM/IVA significantly improved the BMI Z-score and sweat chloride concentration. By contrast, there was no significant change in exacerbation rates, antibiotic use, or CT scan scores. Age at LUM/IVA initiation was lower in good responders and associated with greater ppFEV1 change during the 2 years of treatment. LUM/IVA was well-tolerated.Conclusion: In F508del homozygote adolescents, real-life long-term LUM/IVA improved the ppFEV1 trajectory, particularly in the youngest patients, nutritional status, and sweat chloride concentration but not exacerbation rates or radiological scores. LUM/IVA was generally well-tolerated and safe.
Polygoni Multiflori Radix Praeparata Ethanol Extract Exerts a Protective Effect Against High-Fat Diet Induced Non-Alcoholic Fatty Liver Disease in Mice by Remodeling Intestinal Microbial Structure and Maintaining Metabolic Homeostasis of Bile Acids
Authors: Dai Xuyang , He Linfeng , Hu Naihua , Guo Chaocheng , Zhou Mengting , Zhao Xingtao , Wang Cheng , Gong Lihong , Ma Cheng , Xue Xinyan , Li Yunxia 
Published: November 2021

In the prescription of Traditional Chinese Medicine for lipid metabolism, Polygoni Multiflori Radix Preparata (ZhiHeShouWu, RPMP) was widely used. In recent years, RPMP ethanol extract has been reported for the treatment of non-alcoholic fatty liver disease (NAFLD). However, the role of RPMP ethanol extract in the treatment of NAFLD has not been fully elucidated. Therefore, we examined the optimal therapeutic dose of RPMP ethanol extracts. Afterward, a mouse model of non-alcoholic fatty liver induced by a high-fat diet (HFD) was treated with RPMP ethanol extract to further evaluate the mechanism of action of RPMP ethanol extract treatment. And the serum lipid metabolism indexes and liver function indexes showed that the RPMP ethanol extract in the 1.35 g/kg dose group exhibited better therapeutic effects than the 2.70 g/kg dose group. Meanwhile, RPMP ethanol extract can regulate the biochemical indicators of serum and liver to normal levels, and effectively reduce liver steatosis and lipid deposition. RPMP ethanol extract treatment restored HFD-induced disruption of the compositional structure of the intestinal microbial (IM) and bile acids (BAs) pools. And restore the reduced expression of intestinal barrier-related genes caused by HFD administration, which also effectively regulates the expression of genes related to the metabolism of BAs in mice. Thus, RPMP ethanol extract can effectively improve the abnormal lipid metabolism and hepatic lipid accumulation caused by HFD, which may be related to the regulation of IM composition, maintenance of intestinal barrier function, and normal cholesterol metabolism in the body.
Research Progress on Terahertz Quantum-Well Photodetector and Its Application
Authors: Shao Dixiang , Fu Zhanglong , Tan Zhiyong , Wang Chang , Qiu Fucheng , Gu Liangliang , Wan Wenjian , Cao Juncheng 
Published: November 2021

Compared with other typical terahertz (THz) detectors, the quantum-well photodetector (QWP) has the advantages of high detection sensitivity, fast response, mature fabrication, small size, and easy integration. Therefore, it is suitable for high-speed detection and imaging applications at the THz band. Researchers, both domestic and overseas, have systematically studied material design and device performance of the THz QWP. The design of the device is such that the peak frequency error is within 8%, the maximum peak responsibility is 5.5 A/W, the fastest response speed is 6.2 GHz, the best noise equivalent power is ∼10−13 W/Hz0.5, and the spectrum range is 2.5–6.5 THz. In this article, firstly the basic principles and theoretical calculations of the THz QWP are described, and then the research progress of the THz QWP in our research group at imaging and communication is reviewed, which looks forward to its future development.
Feasibility of Data-Driven, Model-Free Quantitative MRI Protocol Design: Application to Brain and Prostate Diffusion-Relaxation Imaging
Authors: Grussu Francesco , Blumberg Stefano B. , Battiston Marco , Kakkar Lebina S. , Lin Hongxiang , Ianuş Andrada , Schneider Torben , Singh Saurabh , Bourne Roger , Punwani Shonit , Atkinson David , Gandini Wheeler-Kingshott Claudia A. M. , Panagiotaki Eleftheria , Mertzanidou Thomy , Alexander Daniel C. 
Published: November 2021

Purpose: We investigate the feasibility of data-driven, model-free quantitative MRI (qMRI) protocol design on in vivo brain and prostate diffusion-relaxation imaging (DRI).Methods: We select subsets of measurements within lengthy pilot scans, without identifying tissue parameters for which to optimise for. We use the “select and retrieve via direct upsampling” (SARDU-Net) algorithm, made of a selector, identifying measurement subsets, and a predictor, estimating fully-sampled signals from the subsets. We implement both using artificial neural networks, which are trained jointly end-to-end. We deploy the algorithm on brain (32 diffusion-/T1-weightings) and prostate (16 diffusion-/T2-weightings) DRI scans acquired on three healthy volunteers on two separate 3T Philips systems each. We used SARDU-Net to identify sub-protocols of fixed size, assessing reproducibility and testing sub-protocols for their potential to inform multi-contrast analyses via the T1-weighted spherical mean diffusion tensor (T1-SMDT, brain) and hybrid multi-dimensional MRI (HM-MRI, prostate) models, for which sub-protocol selection was not optimised explicitly.Results: In both brain and prostate, SARDU-Net identifies sub-protocols that maximise information content in a reproducible manner across training instantiations using a small number of pilot scans. The sub-protocols support T1-SMDT and HM-MRI multi-contrast modelling for which they were not optimised explicitly, providing signal quality-of-fit in the top 5% against extensive sub-protocol comparisons.Conclusions: Identifying economical but informative qMRI protocols from subsets of rich pilot scans is feasible and potentially useful in acquisition-time-sensitive applications in which there is not a qMRI model of choice. SARDU-Net is demonstrated to be a robust algorithm for data-driven, model-free protocol design.
Online User Information Sharing and Government Pandemic Prevention and Control Strategies-Based on Evolutionary Game Model
Authors: Xiao Yao , Xu Wanting , Zeng Shouzhen , Peng Qiao 
Published: November 2021

Background: The sharing and utilization of online users' information has become an important resource for governments to manage COVID-19; however, it also involves the risk of leakage of users' personal information. Online users' sharing decisions regarding personal information and the government's COVID-19 prevention and control decisions influence each other and jointly determine the efficiency of COVID-19 control and prevention.Method: Using the evolutionary game models, this paper examines the behavioral patterns of online users and governments with regard to the sharing and disclosure of COVID-19 information for its prevention and control.Results: This paper deduce the reasons and solutions underlying the contradiction between the privacy risks faced by online users in sharing information and COVID-19 prevention and control efforts. The inconsistency between individual and collective rationality is the root cause of the inefficiency of COVID-19 prevention and control.Conclusions: The reconciliation of privacy protection with COVID-19 prevention and control efficiency can be achieved by providing guidance and incentives to modulate internet users' behavioral expectations.
Genetic Profile of Adenomatoid Odontogenic Tumor and Ameloblastoma. A Systematic Review
Authors: Marín Constanza , Niklander Sven E. , Martínez-Flores René 
Published: November 2021

Purpose: To perform a comprehensive and systematic critical appraisal of the genetic alterations reported to be present in adenomatoid odontogenic tumor (AOT) compared to ameloblastoma (AM), to aid in the understanding in their development and different behavior.Methods: An electronic search was conducted in PubMed, Scopus, and Web of Science during March 2021. Eligibility criteria included publications on humans which included genetic analysis of AOT or AM.Results: A total of 43 articles reporting 59 AOTs and 680 AMs were included. Different genomic techniques were used, including whole-exome sequencing, direct sequencing, targeted next-generation sequencing panels and TaqMan allele-specific qPCR. Somatic mutations affecting KRAS were identified in 75.9% of all AOTs, mainly G12V; whereas a 71% of the AMs harbored BRAF mutations, mainly V600E.Conclusions: The available genetic data reports that AOTs and AM harbor somatic mutations in well-known oncogenes, being KRAS G12V/R and BRAFV600E mutations the most common, respectively. The relatively high frequency of ameloblastoma compared to other odontogenic tumors, such as AOT, has facilitated the performance of different sequencing techniques, allowing the discovery of different mutational signatures. On the contrary, the low frequency of AOTs is an important limitation for this. The number of studies that have a assessed the genetic landscape of AOT is still very limited, not providing enough evidence to draw a conclusion regarding the relationship between the genomic alterations and its clinical behavior. Thus, the presence of other mutational signatures with clinical impact, co-occurring with background KRAS mutations or in wild-type KRAS cases, cannot be ruled out. Since BRAF and RAS are in the same MAPK pathway, it is interesting that ameloblastomas, frequently associated with BRAFV600E mutation have aggressive clinical behavior, but in contrast, AOTs, frequently associated with RAS mutations have indolent behavior. Functional studies might be required to solve this question.
MEMBANGUN SITUS JEJARING SOSIAL SEBAGAI MEDIA KOMUNIKASI MAHASISWA STMIK KHARISMA PADA JARINGAN LAN
Authors: Willys  
Published: November 2021

Tujuan dari laporan skripsi ini adalah untuk membuat sebuah halaman website yang digunakan oleh mahasiswa STMIK Kharisma Karawang yang bertujuan agar antar mahasiswa dapat saling berkomunikasi tanpa harus ada sebuah jaringan internet untuk masuk kehalaman ini, karena media komunikasi ini dapat diakses melaui local area network (LAN) pada sebuah server yang terdapat pada kampus STMIK Kharisma Karawang.
Dengan adanya media komunikasi ini kedepannya mahasiswa STMIK Kharisma Karawang dapat saling berkomunikasi dengan teman – teman beda angkatan agar terjalin silahturahmi yang kuat.

Kata Kunci : Sosial Media, Jaringan LAN
Constraining Type Ia Supernova Delay Time with Spatially Resolved Star Formation Histories
Authors: Chen Xingzhuo , Hu Lei , Wang Lifan 
Published: November 2021

Abstract
We present the delay time distribution (DTD) estimates of Type Ia supernovae (SNe Ia) using spatially resolved SN Ia host galaxy spectra from MUSE and MaNGA. By employing a grouping algorithm based on k-means and earth mover’s distances (EMDs), we separated the host galaxy stellar population age distributions (SPADs) into spatially distinct regions and used maximum likelihood method to constrain the DTD of SN Ia progenitors. When a power-law model of the form DTD(t) ∝ t

s
(t > τ) is used, we find an SN rate decay slope

s
=
−

1.41

−
0.33

+
0.32

and a delay time

τ
=

120

−
83

+
142

Myr

. Moreover, we tested other DTD models, such as a broken power-law model and a two-component power-law model, and found no statistically significant support for these alternative models.
Dynamical Friction in Nonlocal Gravity
Authors: Roshan Mahmood , Mashhoon Bahram 
Published: November 2021

Abstract
We study dynamical friction in the Newtonian regime of nonlocal gravity (NLG), which is a classical nonlocal generalization of Einstein’s theory of gravitation. The nonlocal aspect of NLG simulates dark matter. The attributes of the resulting effective dark matter are described and the main physical predictions of NLG, which has a characteristic length scale of order 1 kpc, for galactic dynamics are presented. Within the framework of NLG, we derive the analog of Chandrasekhar’s formula for dynamical friction. The astrophysical implications of the results for the apparent rotation of a central bar subject to dynamical friction in a barred spiral galaxy are briefly discussed.
Detection of the Mass-dependent Dual Type Transition of Galaxy Spins in IllustrisTNG Simulations
Authors: Lee Jounghun , Moon Jun-Sung , Ryu Suho , Yoon Suk-Jin 
Published: November 2021

Abstract
A numerical detection of the mass-dependent spin transition of the galaxies is presented. Analyzing a sample of the galaxies with stellar masses in the range of 109 < (M
⋆/M
⊙) ≤ 1011 from the IllustrisTNG300-1 simulations, we explore the alignment tendency between the galaxy baryon spins and the three eigenvectors of the linearly reconstructed tidal field as a function of M
⋆ and its evolution in the redshift range of 0 ≤ z ≤ 1.5. Detecting a significant signal of the occurrence of the mass-dependent transition of the galaxy spins, we show that the centrals differ from the satellites in their spin transition type. As M
⋆ increases beyond a certain threshold mass, the preferred directions of the central galaxy spins transit from the minor to the intermediate tidal eigenvectors (type two) at z = 0.5 and 1, while those of the satellites transit from the minor to the major tidal eigenvectors (type one) at z = 1 and 1.5. It is also shown that the mass range and type of the spin transition depend on the galaxy morphology, the degree of the alignments between the baryon and total spin vectors, and the environmental density. Meanwhile, the stellar spins of the galaxies are found to yield a weak signal of the T1 transitions at z = 0, whose strength and trend depend on the degree of the alignments between the stellar and baryon spins. The possible mechanisms responsible for the T1 and T2 spin transitions are discussed.
EPIC 228782059: Asteroseismology of What Could Be the Coolest Pulsating Helium-atmosphere White Dwarf (DBV) Known
Authors: Duan R. M. , Zong W. , Fu J.-N. , Chen Y. H. , Hermes J. J. , Vanderbosch Zachary P. , Ma X. Y. , Charpinet S. 
Published: November 2021

Abstract
We present analysis of a new pulsating helium-atmosphere (DB) white dwarf, EPIC 228782059, discovered from 55.1 days of K2 photometry. The long-duration, high-quality light curves reveal 11 independent dipole and quadruple modes, from which we derive a rotational period of 34.1 ± 0.4 hr for the star. An optimal model is obtained from a series of grids constructed using the White Dwarf Evolution Code, which returns M
* = 0.685 ± 0.003M
⊙, T
eff = 21,910 ± 23 K, and

log
g
=
8.14
±
0.01

dex. These values are comparable to those derived from spectroscopy by Koester & Kepler (20,860 ± 160 K, and 7.94 ± 0.03 dex). If these values are confirmed or better constrained by other independent works, it would make EPIC 228782059 one of the coolest pulsating DB white dwarf stars known, and would be helpful for testing different physical treatments of convection, and to further investigate the theoretical instability strip of DB white dwarf stars.
Characteristics, Comorbidities, and Outcomes of SARS-CoV-2 Infection in Patients With Autoimmune Conditions Treated With Systemic Therapies: A Population-based Study
Authors: Curtis Jeffrey R. , Zhou Xiaofeng , Rubin David T. , Reinisch Walter , Yazdany Jinoos , Robinson Philip C. , Chen Yan , Benda Birgitta , Madsen Ann , Geier Jamie 
Published: November 2021

ObjectiveTo describe characteristics and coronavirus disease 2019 (COVID-19) clinical outcomes of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), or ulcerative colitis (UC) receiving systemic therapies vs the general population.MethodsThis descriptive retrospective cohort study used data from the United States Optum deidentified COVID-19 electronic health record dataset (2007–2020). Adults with COVID-19 were stratified into 3 disease cohorts (patients with RA, PsA, or UC who had received systemic therapy) and a comparator cohort not meeting these criteria. Incidence proportions of hospitalization and clinical manifestations of interest were calculated. Using logistic regression analyses, risk of endpoints was estimated, adjusting for demographics and demographics plus comorbidities.ResultsThis analysis (February 1 to December 9, 2020) included 315,101 patients with COVID-19. Adjusting for demographics, COVID-19 patients with RA (n = 2306) had an increased risk of hospitalization (OR 1.54, 95% CI 1.39–1.70) and in-hospital death (OR 1.61, 95% CI 1.30–2.00) compared with the comparator cohort (n = 311,563). The increased risk was also observed when adjusted for demographics plus comorbidities (hospitalization OR 1.25, 95% CI 1.13–1.39 and in-hospital death OR 1.35, 95% CI 1.09–1.68]). The risk of hospitalization was lower in COVID-19 patients with RA receiving tumor necrosis factor inhibitors (TNFi) vs non-TNFi biologics (OR 0.32, 95% CI 0.20–0.53) and the comparator cohort (OR 0.77, 95% CI 0.51–1.17). The risk of hospitalization due to COVID-19 was similar between patients receiving tofacitinib and the comparator cohort.ConclusionCompared with the comparator cohort, patients with RA were at a higher risk of more severe or critical COVID-19 and, except for non-TNFi biologics, systemic therapies did not further increase the risk. (ENCePP; registration no. EU PAS 35384)
They Never Walked Alone. Workshop, Seminars, Conferences and the Making of Virginia Political Economy
Authors: Boettke Peter J. , Marciano Alain , Stein Solomon 
Published: November 2021

L’objet de cet article est d’étudier la manière dont la recherche s’est organisée au sein des deux centres qui ont joué un rôle fondamental à la création, l’émergence et le développement de l’école d’économie politique de Virginie (VPE) : Le Thomas Jefferson Center for Studies in Political Economy and Social Philosophy (Université de Virginie) et le Center for the Study of Public Choice (Institut Polytechnique de Virginie et Université George Mason). Nous analysons le rôle joué par les ateliers, séminaires et conférences. Nous nous basons sur des éléments d’archives qui n’avaient pas été utilisés dans les précédents histoires racontées sur VPE. Nous insistons aussi sur le rôle joué par James Buchanan, dont les idées sont indissociables de VPE. Une histoire de VPE peut, en effet, difficilement être racontée sans faire une grande place à Buchanan.
The Cowles Summer Research Conferences on Economics and Statistics 1935-1940: Building a Community for Mathematical Economics and Econometrics
Authors: W. Dimand Robert 
Published: November 2021

La Cowles Commission for Research in Economics a organisé six conférences estivales à Colorado Springs, de 1935 à 1940. Ces conférences, étroitement associées aux réunions de l’Econometric Society, ont su créer un forum dédié aux économistes, théoriciens ou statisticiens, qui affichaient une appétence particulière pour la formalisation. Elles leur ont permis d’interagir, de présenter leurs travaux, et d’obtenir les retours et critiques constructives d’un auditoire empathique, dans un contexte professionnel assez réfractaire à ce type de recherches. Contrairement aux réunions de l’Econometric Society et des principales associations scientifiques, n’offrant généralement qu’un unique week-end de sessions parallèles, les Cowles conferences s’étendaient sur une période d’un mois entier, réservant une demijournée à chaque article, en sus de conférences publiques. Les résumés détaillés des articles étaient publiés dans le volume annuel de la conférence, certains soumis dans leur version intégrale à Econometrica (revue bénéficiant alors du soutien financier d’Alfred Cowles). Ces conférences ont attiré d’éminents économistes, venus d’Europe ou des États-Unis. A une époque où les financements publics restaient limités (à l’exception notable du domaine agricole), Alfred Cowles, troisième du nom, a joué un rôle crucial en parrainant le tournant mathématique et statistique en économie, à l’image du rôle joué, aux États-Unis durant les années 1930, par Alfred Loomis dans le champ de la physique. Les Annual Research Conferences on Economics and Statistics patronnées par Cowles ont ainsi permis de rassembler les principaux protagonistes de ce tournant, favorisant des échanges intellectuels approfondis et prolongés. Les années Colorado de la Commission Cowles, par le biais de ses conférences d’été notamment, ont contribué à la création d’une communauté de chercheurs dévoués à « l’avancement de la théorie économique en relation avec les mathématiques et les statistiques », aboutissant à une reconnaissance institutionnelle lors de son déménagement à l’Université de Chicago en 1939, puis à Yale à partir de 1955, sous le nom de Cowles Foundation.