bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decoding the Complex Free Radical Cascade by Using a DNA Framework‐Based Artificial DNA Encoder
Authors: Zhang Lili , Wang Linlin , Yuan Xi , Zhong Minjuan , Chen Hong , Zhang Dailiang , Han Xiaoyan , Xie Sitao , He Lei , Li Yazhou , Chen Fengming , Liu Yanlan , Tan Weihong 
Published: February 2021

AbstractDNA‐based molecular communications (DMC) are critical for regulating biological networks to maintain stable organismic functions. However, the complicated, time‐consuming information transmission process involved in genome‐coded DMC and the limited, vulnerable decoding activity generally lead to communication impairment or failure, in response to external stimuli. Herein, we present a conceptually innovative DMC strategy mediated by the DNA framework‐based artificial DNA encoder. With the free‐radical cascade as a proof‐of‐concept study, the artificial DNA encoder shows active sensing and real‐time actuation, in situ and broad free radical‐decoding efficacy, as well as robust resistance to environmental noise. It can also block undesirable short‐to‐medium‐range communications between free radicals and inflammatory networks, leading to a synergistic anti‐obesity effect. The artificial DNA encoder‐based DMC may be generalized to other communication systems for a variety of applications.
Asymmetric Synthesis of N‐Substituted α‐Amino Esters from α‐Ketoesters via Imine Reductase‐Catalyzed Reductive Amination
Authors: Yao Peiyuan , Marshall James R. , Xu Zefei , Lim Jesmine , Charnock Simon J. , Zhu Dunming , Turner Nicholas J. 
Published: February 2021

AbstractN‐Substituted α‐amino esters are widely used as chiral intermediates in a range of pharmaceuticals. Here we report the enantioselective biocatalyic synthesis of N‐substituted α‐amino esters through the direct reductive coupling of α‐ketoesters and amines employing sequence diverse metagenomic imine reductases (IREDs). Both enantiomers of N‐substituted α‐amino esters were obtained with high conversion and excellent enantioselectivity under mild reaction conditions. In addition >20 different preparative scale transformations were performed highlighting the scalability of this system.
Failure to meet extubation criteria in the setting of suspected buffalo chest physiology
Authors: Chu R. F. , Scott A. V. , Wright N. R. 
Published: February 2021

SummaryWe report the case of a patient who failed to meet tracheal extubation criteria due to low tidal volumes from suspected buffalo chest, which is a single pleural space physiology. This presentation followed the resection of a large pleural mass in a 59‐year‐old woman with a history of exercise‐induced asthma, hypertension and tumour‐related chronic respiratory failure. Creation of a pleuro‐pleural communication during the resection of this large, unilateral pleural mass led to bilateral pneumothoraces and contributed to patients inability to generate negative inspiratory force leading to failure to meet extubation criteria. Buffalo chest may be more prevalent than suspected and should be a differential diagnosis for low tidal volumes with spontaneous ventilation following thoracic surgery. It can be differentiated from other causes of decreased tidal volume using clinical examination, ultrasound and radiography. Bilateral chest tube placement can be considered to expedite pneumothorax resolution and tracheal extubation.
Thiol‐terminated hyperbranched polymer for DLP 3D printing: Performance evaluation of a low shrinkage photosensitive resin
Authors: Li Songyi , Cui Yihua , Li Jingjing 
Published: February 2021

AbstractIn order to lower the volume shrinkage of the DLP 3D printing photosensitive resins during printing, a thiol‐terminated hyperbranched polymer (T‐HBP) was synthesized and introduced into the bisphenol A epoxy acrylate (EA) based photosensitive resin system. The obtained T‐HBP was characterized by FTIR and 1H NMR spectra, and the grafting rate of sulfhydryl was determined. The mechanical properties of the photosensitive resins were measured by tensile and impact strength measurement. The glass transition temperature of the photosensitive resins was analyzed by DSC and the impact fracture surface was observed by SEM. T‐HBP exhibited a much lower viscosity than its linear counterparts, and the addition of thiol improved the curing speed of the photosensitive resins. When the amount of T‐HBP added was 20 wt%, the shrinkage of the photosensitive resins was reduced by about 45.5% and the impact strength increased by 33.9% compared with the control. The macromolecular spherical structure of T‐HBP effectively reduced the functional group density of the photosensitive resins. In addition, the thiol‐acrylate photopolymerization introduced by T‐HBP further reduced the volume shrinkage of the photosensitive resins.
Subdivisions of the mesencephalon and isthmus in the lizardGekko geckoas revealed byChATimmunohistochemistry
Authors: Wang Xiao‐Qing , Wang Wen‐Bo , Tang Ye‐Zhong , Dai Zhen‐Dong 
Published: February 2021

AbstractThe distribution of cholinergic cell bodies and fibers was examined in the mesencephalon and isthmus ofGekko gecko. Distinct groups with prominent labeled cells were observed in the cranial nerve motor nuclei and isthmic nuclei, and weak labeled cell bodies and fibers were observed in the mesencephalic nucleus of the trigeminal nerve and the central nucleus of the torus semicircularis. After discussing the topological relationships within the tectum and isthmus, we unify the nomenclature of the caudal deep mesencephalic nucleus in lizards and the rostral magnocellular nucleus isthmi in turtles that is similar in terms of the preisthmic position, nontopographic connections with the tectum, and the same midbrain origin to the magnocellular preisthmic nucleus in birds, and may be homologous to the superficial cuneiform nucleus in mammals. None of them belong to the cholinergic nucleus isthmi, as the latter has isthmus origin and topographic reciprocal connections with the tectum. We also discuss the origin and intrinsic function of the inner longitudinal tract of the thick ChAT‐ir fibers that course through the mesencephalon and diencephalon. We review the subdivisions of the mesencephalon and isthmus ofGekko geckoas revealed by ChAT immunohistochemistry, as well as the limits of the diencephalo–mesencephalic, mesencephalic–isthmo, and isthmo–rhombocephalic by the ChAT‐ir cell‐ and fiber‐poor distribution, and discuss the caudal limit of the isthmus. Our research on the subdivisions of the mesencephalon and isthmus inG. geckoas revealed by ChAT immunohistochemistry will serve as the neuroanatomical basis for subsequent relevant studies ofGekko gecko.
Studying the onset of deconfinement with multi‐messenger astronomy of neutron stars
Authors: Blaschke David , Cierniak Mateusz 
Published: February 2021

AbstractWith the first multi‐messenger observation of a binary neutron star merger (GW170817), new constraints became available for masses and radii of neutron stars. We introduce a class of hybrid EoS that fulfills all these constraints and predicts a region in the mass‐radius diagram that could be populated only by hybrid neutron stars with quark matter cores. A confirmation of this conjecture would be provided when the NICER radius measurement for the high‐mass pulsar PSR J0740 + 6620 yields a radius significantly less than 11 km. Would this radius measurement yield a result in excess of 12 km, this would allow for both, a purely hadronic and a hybrid nature of this star. In the latter case, the maximum mass could reach 2.6 M⊙ so that the lighter object in the asymmetric binary merger GW190814 could have been a hybrid star. We demonstrate that this high mass can be compatible with an early onset of deconfinement for stars with masses below 1 M⊙ and the occurrence of low‐mass twin stars. In such a case, the remnant of GW170817 could be a long‐lived hypermassive pulsar.
23Na Solid‐State NMR Analyses for Na‐Ion Batteries and Materials
Authors: Gotoh Kazuma 
Published: February 2021

AbstractSodium‐ion batteries (NIBs) have received considerable attention as next‐generation batteries that complement or replace the current demand for lithium‐ion batteries. For the development of NIBs, elucidating the states of sodium ions and understanding the charging‐discharging mechanism on the electrodes is indispensable for achieving high capacity, high efficiency, long life, and reasonably safe performance. Solid‐state nuclear magnetic resonance (SS‐NMR) is a powerful tool for obtaining direct information on nuclei as it can detect information on sodium and distinguish different electronic circumstances. In this minireview, recent progress on NMR analyses of NIB electrode materials (cathode and anode) is outlined. 23Na NMR signals of NaMnO2‐type cathodes, which are usually affected by the strong effect of paramagnetic species and other cathode materials, are introduced. Additionally, NMR analyses of hard carbon, graphite, and other inorganic anode materials are summarized.
Pushing Raman spectroscopy over the edge: purported signatures of organic molecules in fossil animals are instrumental artefacts
Authors: Alleon Julien , Montagnac Gilles , Reynard Bruno , Brulé Thibault , Thoury Mathieu , Gueriau Pierre 
Published: February 2021

AbstractWidespread preservation of fossilized biomolecules in many fossil animals has recently been reported in six studies, based on Raman microspectroscopy. Here, we show that the putative Raman signatures of organic compounds in these fossils are actually instrumental artefacts resulting from intense background luminescence. Raman spectroscopy is based on the detection of photons scattered inelastically by matter upon its interaction with a laser beam. For many natural materials, this interaction also generates a luminescence signal that is often orders of magnitude more intense than the light produced by Raman scattering. Such luminescence, coupled with the transmission properties of the spectrometer, induced quasi‐periodic ripples in the measured spectra that have been incorrectly interpreted as Raman signatures of organic molecules. Although several analytical strategies have been developed to overcome this common issue, Raman microspectroscopy as used in the studies questioned here cannot be used to identify fossil biomolecules.
Green supply chain integration and financial performance: A social contagion and information sharing perspective
Authors: Kong Ting , Feng Taiwen , Huo Baofeng 
Published: February 2021

AbstractAlthough green supply chain integration (GSCI) has received wide attention, how it diffuses among supply chain members to affect the manufacturer's performance is still unclear. This study examines the relationships among GSCI, information sharing, and financial performance from a social contagion lens. By conceptualizing GSCI into three forms, two types of contagion mechanisms (i.e., cohesion and structural equivalence) were identified to investigate the underlying contagion effects between different forms of GSCI and the effects of various GSCI on information sharing and financial performance. Survey data were collected from 206 Chinese manufacturers and analyzed using structural equation modeling to test hypotheses. The results indicate that green supplier integration directly promotes green internal integration, green customer integration, and information sharing with suppliers. Green internal integration positively influences green customer integration and financial performance. Green customer integration enhances information sharing with customers. Both information sharing with suppliers and customers improve financial performance. This study contributes to the GSCI literature and provides novel managerial implications for manufacturers.
Real‐world experience of suture‐based closure devices: Insights from the FDA Manufacturer and User Facility Device Experience
Authors: Case Brian C. , Kumar Sant , Yerasi Charan , Forrestal Brian J. , Musallam Anees , Chezar‐Azerrad Chava , Khalid Nauman , Shlofmitz Evan , Chen Yuefeng , Khan Jaffar M. , Satler Lowell F. , Ben‐Dor Itsik , Hashim Hayder , Bernardo Nelson L. , Rogers Toby , Waksman Ron 
Published: February 2021

AbstractObjectivesWe analyzed post‐marketing surveillance data from the United States Food and Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE) database for suture‐based vascular closure devices (VCDs) – Perclose ProGlide (Abbott, Chicago, Illinois) and Prostar XL (Abbott).BackgroundSuture‐based VCDs are mostly used for large‐bore femoral arterial access‐site closure. Real‐world, contemporary experience on the most commonly reported complications and modes of failure associated with these devices is limited.MethodsPost‐marketing surveillance data from the FDA MAUDE database, for the ProGlide system and for the Prostar XL system, were analyzed, yielding 827 Perclose ProGlide reports and 175 Prostar XL reports.ResultsOf the 827 reports of major complications involving the Perclose ProGlide devices, 404 reports involved injury, and one involved death related to the device. In the Prostar XL analysis, 94 reports involved injury, and one involved death. Bleeding from vessel injury was the most common adverse outcome described with both devices, followed by hematoma and thrombus. Surgical repair was the most commonly used treatment strategy. In terms of device malfunction, suture‐related malfunction (212 reports) was most commonly seen in the Perclose ProGlide group, while failed deployment was most commonly seen in the Prostar XL group.ConclusionsOur analysis of the MAUDE database demonstrates that in real‐world practice, suture‐based VCDs were found to be associated with complications, including vascular injury, difficulties with the device itself, and even death. Ongoing user education and pre‐procedural patient selection are important to minimize risks associated with suture‐based vascular closure devices.
Intestinal pseudo‐obstruction: Unusual presentation of systemic lupus erythematous
Authors: Ayari Myriam , Nakhli Abdelwaheb , Teyeb Zeineb , Abdelaali Imen , Bellakhal Syrine , Jomni Taieb 
Published: February 2021

AbstractSystemic diseases should be always considered when managing unexplained intestinal pseudo‐obstruction. Intestinal pseudo‐obstruction related to systemic lupus erythematosus is often responsive to corticosteroid therapy when promptly treated.
Organic Nanoparticles with Persistent Luminescence for In Vivo Afterglow Imaging‐Guided Photodynamic Therapy
Authors: Zheng Xiaokun , Wu Wenbo , Zheng Yue , Ding Yiwen , Xiang Yu , Liu Bin , Tong Aijun 
Published: February 2021

AbstractOptical imaging‐guided photodynamic therapy (PDT), with precise localization and non‐invasive treatment of tumors, is an emerging technique with great potential for cancer therapy. However, impaired by tissue auto‐fluorescence that causes low signal‐to‐background ratio (SBR), most fluorescence imaging systems show poor sensitivity to tumors in vivo. In this study, we synthesized organic nanoparticles (ONPs) with persistent luminescence and good biocompatibility for afterglow imaging‐guided PDT. The ONPs displayed near‐infrared light emission with half‐life time at minute level, which offered high SBR and good tissue penetration for in vivo afterglow tumor imaging. Taking advantage of their abundant singlet oxygen generation by NIR laser irradiation guided to the tumor sites, the ONPs also enabled imaging‐guided PDT for efficient suppression of tumor growth in mice with minimal damage to major organs.
Co‐Catalyzed Asymmetric Intramolecular [3+2] Cycloaddition of Yne‐Alkylidenecyclopropanes and its Reaction Mechanism
Authors: Xiao Xiong , Yu Zhi‐Xiang 
Published: February 2021

AbstractDeveloping new transition metal‐catalyzed asymmetric cycloadditions for the synthesis of five‐membered carbocycles (FMCs) is a research frontier in reaction development due to the ubiquitous presence of chiral FMCs in various functional molecules. Reported here is our discovery of a highly enantioselective intramolecular [3+2] cycloaddition of yne‐alkylidenecyclopropanes (yne‐ACPs) to bicyclo[3.3.0]octadiene and bicyclo[4.3.0]nonadiene molecules using a cheap Co catalyst and commercially available chiral ligand (S)‐Xyl‐BINAP. This reaction avoids the use of precious Pd and Rh catalysts, which are usually the choices for [3+2] reactions with ACPs. The enantiomeric excess in the present reaction can be up to 92 %. Cationic cobalt(I) species was suggested by experiments as the catalytic species. DFT calculations showed that this [3+2] reaction starts with oxidative cyclometallation of alkyne and ACP, followed by ring opening of the cyclopropyl (CP) group and reductive elimination to form the cycloadduct. This mechanism is different from previous [3+2] reactions of ACPs, which usually start from CP cleavage, not from oxidative cyclization.
Isoselective Polymerization of rac‐Lactide by Aluminum Complexes of N‐Heterocyclic Carbene‐Phosphinidene Adducts
Authors: Bhattacharjee Jayeeta , Peters Marius , Bockfeld Dirk , Tamm Matthias 
Published: February 2021

AbstractThe N‐heterocyclic carbene‐phosphinidene adducts (NHC)PH were reacted with AlMe3 in toluene to afford the monoaluminum complexes [{(IDipp)PH}AlMe3] and [{(IMes)PH}AlMe3] (IDipp=1,3‐bis(2,6‐diisopropylphenyl)imidazolin‐2‐ylidene, IMes=1,3‐bis(2,4,6‐trimethylphenyl)imidazolin‐2‐ylidene). In contrast, the dialuminum complex [{(MeIMes)PH}(AlMe3)2] was obtained for MeIMes=1,3‐bis(2,4,6‐trimethylphenyl)‐4,5‐dimethylimidazolin‐2‐ylidene. These complexes served as initiators for the efficient ring‐opening polymerization of rac‐lactide in toluene at 60 °C. High degrees of isoselectivity were found for the poly(rac‐lactide) obtained in the presence of the monoaluminum complexes (Pm up to 0.92, Tm up to 191 °C), whereas almost atactic polymers were produced by the dialuminum complex. Detailed mechanistic studies reveal that the polymerization proceeds via a coordination‐insertion mechanism with the carbene‐phosphinidene ligands acting as stereodirecting groups.
ANCA‐associated neuropathy in systemic sclerosis: A case report and review of literature
Authors: Takenaka Kayo , Takeichi Takuya , Nishi Ryoji , Suzuki Masashi , Koike Haruki , Katsuno Masahisa , Ogawa‐Momohara Mariko , Muro Yoshinao , Akiyama Masashi 
Published: February 2021

AbstractSystemic sclerosis (SSc) is a multi‐system autoimmune disease. Anti‐neutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed against enzymes found within primary granules of neutrophils and lysosomes in monocytes. Although up to 12% of SSc patients have ANCA, only a minority of these patients develop an overlap syndrome with ANCA‐associated vasculitis. We summarize previous reports on SSc patients with ANCA‐associated neuropathy. In all the reported cases, the SSc diagnosis preceded the ANCA‐associated neuropathy diagnosis. Seven of the eight patients with limited cutaneous SSc had interstitial lung disease (ILD). Thus, patients with ANCA‐associated neuropathy in lSSc may be prone to complication with ILD.
Tropfenbewegung und Stofftransport in technischen Flüssig/flüssig‐Systemen. Teil 1: Einzeltropfensedimentation ohne Grenzflächeneffekte
Authors: Schulz Joschka M. , Petzold Marc , Böhm Lutz , Kraume Matthias 
Published: February 2021

AbstractFür die Dimensionierung von Flüssig/flüssig‐Kontaktapparaten sind Fluiddynamik und Stofftransport in der Dispersion von entscheidender Bedeutung. Schwarm‐ und Grenzflächeneffekte führen zu komplexen Interaktionen und erschweren die Vorhersage von Betriebsparametern. Anhand von Einzeltropfenuntersuchungen kann eine grundlegende Vorhersage für fluiddynamisches Verhalten und Stofftransportleistung auf Basis einfacher Experimente und zahlreicher publizierter Korrelationen und Theorien getroffen werden. Dieser zweiteilige Beitrag befasst sich mit den Grundlagen von Fluiddynamik und Stofftransport von Einzeltropfen sowie der Auswirkung von Grenzflächeneffekten und für technische Systeme üblichen Verunreinigungen auf die Transportprozesse in dispersen Systemen.
Auf der Suche nach der nachhaltigen Proteinquelle der Zukunft
Authors: Cifci Deniz , Hebenbrock André , Siwek Dominika , Stagge Hannes , Weseler Lydia 
Published: February 2021

AbstractDie Nahrungsmittelindustrie verursacht durch die Produktion von tierischen – aber auch pflanzlichen Lebensmitteln mit hohem Proteingehalt einen großen Beitrag zur Klimaerwärmung. Die Aufgabe des chemPLANT‐Wettbewerbs 2020 der kreativen jungen Verfahrensin
FILTECH 2021 – Aufgeschoben ist nicht aufgehoben
Authors: Anlauf Harald 
Published: February 2021

AbstractDas für die FILTECH 2021 bereits fertiggestellte wissenschaftlich/technische Programm für die Konferenz gibt dennoch einen sehr guten Überblick Über den aktuellen internationalen Stand von Forschung und Entwicklung auf dem Gebiet der Partikel‐Trenntechnik
Amine‐Free Synthesis of Colloidal Cesium Lead Halide Perovskite Nanocrystals
Authors: Akhil Syed , Dutt V. G. Vasavi , Mishra Nimai 
Published: February 2021

AbstractColloidal cesium lead halide (CsPbX3) perovskite nanocrystals (PNCs) are of great interest in research because of their excellent optical properties and exceptional colour tunability. Oleic acid and oleylamine are the most commonly used surface capping ligands in colloidal CsPbX3 synthesis. The oleylamine plays an important role in surface passivation and maintaining colloidal stability. But in a long run, it is responsible for poor colloidal stability because of the facile proton exchange leading to the formation of labile oleylammonium halide, which pulls the halide ions out of the NC surface. By leveraging the synthetic toolboxes developed from decades of research into more traditional semiconductor nanocrystals, very recently researchers focused on developing various amine‐free synthesis approaches to improve the colloidal and photostability of CsPbX3 perovskite NCs. In this review, we have summarized various amine‐free based synthetic routes of CsPbX3 (X=Cl, Br, I) PNCs that are reported to date. We reviewed this progress in terms of their underlying synthetic approaches, and post‐synthetic treatment steps. Furthermore, we reviewed and analyzed the prospects of these perovskite nanocrystals in terms of their photo‐luminescence properties and device performances. In going forward, a deeper understanding of the role of precursors and ligands will significantly bolster the versatility of these amine‐free PNC materials.