bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blind Love, Risky Romance: Exposure to Romantic Cues Increases Nonmoral and Immoral Risk Taking
Authors: Li Heng 
Published: February 2025

ABSTRACTLove and risk are often intricately intertwined within linguistic and cultural conventions. This study experimentally tested the hypothesis that risk‐taking attitudes and behaviors are systematically influenced by romantic primes. To evaluate our theoretical framework, we conducted four complementary experiments utilizing various priming techniques (lexical cues, advertisements, and storytelling), diverse participant populations (students and general adults), and multiple measures of risk‐taking behavior (self‐report and behavioral data). Study 1 compared students' tendencies to engage in risk taking when exposed to romantic cues versus neutral primes. Studies 2 and 3 aimed to provide behavioral confirmation of the observed effects in nonmoral and immoral risk‐taking behaviors among nonstudent participants. Study 4 sought to provide more direct evidence regarding the role of self‐control in explaining the effects of romantic cues on risk taking. We found both correlational and experimental evidence indicating that participants primed with romantic cues exhibited a higher likelihood of engaging in nonmoral and immoral risk‐taking behaviors compared to those exposed to neutral conditions. Across the studies, self‐control was identified as a mediating factor in the observed effects. In sum, our research demonstrates that the mere presence of romantic themes significantly influences the propensity to engage in risky behaviors.
ShareStats: An open statistics item bank developed by a community of instructors in higher education
Authors: Namesnik‐Silvester Kirsten , Polak Marike , Smits Niels , Swinkels Joukje , Arends Lidia , Pavlopoulos Dimitris , Psychogyiopoulos Anastasios , Lindemann Oliver , Klinkenberg Sharon , de Moor Marleen H. M. 
Published: February 2025

AbstractGaining knowledge of statistics is important in most (under)graduate programs within the social and behavioral sciences and requires repeated study by students, highlighting the need for good practice materials. We describe the development of an open item bank of statistics exercises by a community of instructors from Dutch universities: the ShareStats project. We describe how we developed the item bank by reusing existing statistics exercises from various institutions. The 5000+ exercises are in Dutch or English and are all quality‐checked, categorized, and shared under a Creative Commons License in a single format, which allows for easy export to online learning and testing systems. We describe how we built a professional community of statistics instructors in the Netherlands, which was actively involved in developing the item bank. By continuing to invest in the online item bank and the professional community, we aim to inspire other educators to contribute to open educational resources.
Two O‐acyltransferases from the diterpene biosynthetic gene cluster of Euphorbia lathyris contribute to the structural diversity of medicinal macrocyclic diterpenoid esters biosynthesis
Authors: Zhao Wanli , Wang Fan , Li Pirui , Li Linwei , Ernst Lukas , Huang Long , Tian Mei , Lv Wei , Xu Shu , Liu Fei , Lin Guyin , Lyu Hui , Paetz Christian , Feng Xu , Chen Yu 
Published: February 2025

SUMMARYMacrocyclic diterpenoid esters from Euphorbiaceae plants hold significant medicinal value owing to their structural diversity and for attributing structural uniqueness and biological efficacy. However, the responsible enzymes for the acylation of macrocyclic diterpenoids remain unknown. We identified two macrocyclic diterpenoid O‐acyltransferases, ElBAHD16 and ElBAHD35, from the diterpene biosynthetic gene cluster of Euphorbia lathyris. ElBAHD16 and ElBAHD35 were characterized both in vitro (using Escherichia coli) and in vivo (using Nicotiana benthamiana and E. lathyris) and exhibited mono‐acylation activities toward the hydroxy groups of their substrates, 7‐hydroxylathyrol and lathyrol. ElBAHD16 showed not only regioselectivity toward the 7‐OH group of 7‐hydroxylathyrol but also donor promiscuity, thereby producing three different mono‐acylation products. Conversely, ElBAHD35 demonstrated specific recognition for the 5‐OH group of 7‐hydroxylathyrol and lathyrol, thereby mediating mono‐acetylation reactions with acetyl‐CoA, showing donor specificity. Site‐directed mutagenesis revealed that residues H154 and T363 in ElBAHD16 are critical for its catalytic activity. Notably, the Q35 residue enhanced the efficiency of ElBAHD16, while the M296, N292, and F394 residues were crucial for its donor promiscuity. These findings elucidate the last step in the biosynthesis of macrocyclic diterpenoid esters and highlight the contribution of acyltransferases to the structural diversity of diterpenoids.
Subterranean morphology underpins the degree of mycoheterotrophy, mycorrhizal associations, and plant vigor in a green orchid Oreorchis patens
Authors: Suetsugu Kenji , Okada Hidehito 
Published: February 2025

SUMMARYThe evolution of full heterotrophy is a fascinating topic in plant evolution, with recent studies suggesting that partial mycoheterotrophy (mixotrophy) serves as a transitional stage toward full mycoheterotrophy in orchids. However, the adaptive significance of fungal‐derived carbon in mixotrophic plants remains largely unexplored. In this study, we investigated the photosynthetic orchid Oreorchis patens, a species related to the leafless genus Corallorhiza within the subtribe Calypsoinae. Using high‐throughput DNA sequencing, 13C and 15N isotopic analyses, and phenotypic evaluations, we explored the role of coralloid rhizomes – a feature common in fully mycoheterotrophic orchids – in fungal partnerships, the degree of mycoheterotrophy, and plant vigor. Our findings reveal that O. patens plants with coralloid rhizomes predominantly associate with saprotrophic Psathyrellaceae fungi, whereas those without coralloid rhizomes also partner with rhizoctonias and other potentially orchid mycorrhizal fungi. Notably, plants with coralloid rhizomes exhibited enriched 13C signatures, indicating a greater reliance on fungal‐derived carbon. These plants also demonstrated more vigorous flowering scapes and produced a higher number of flowers, suggesting that mycoheterotrophy significantly enhances plant vigor. This study provides rare insights into the adaptive significance of mycoheterotrophy. Recent research suggests that some partially mycoheterotrophic orchids can adjust their heterotrophic status to optimize carbon resource use under specific conditions, such as low‐light environments. However, an increased proportion of fungal‐derived carbon may sometimes merely reflect reduced photosynthesis in such conditions, thereby amplifying the apparent contribution of fungal‐derived carbon. Our findings offer more direct evidence that carbon acquisition via mycoheterotrophy is beneficial for partially mycoheterotrophic orchids.
Breakage of cementless press‐fit femoral stems following total hip arthroplasty in dogs: 14 cases (2013–2023)
Authors: Carvajal Jose L. , Karlin William M. , Marcellin‐Little Denis J. , Kowaleski Michael P. , Verpaalen Valentine D. , Guiot Laurent P. , Chou Po‐Yen , Barthelemy Nicolas P. , Lotsikas Peter J. , Kim Stanley E. 
Published: February 2025

AbstractObjectiveTo report breakage of press‐fit cementless femoral stems in dogs after total hip arthroplasty (THA).Study designRetrospective case series.AnimalsThirteen dogs (14 stems).MethodsMedical records were obtained for client‐owned dogs that underwent THA between 2013 and 2023. Demographic data, implant type and size, time to stem breakage, and radiographic assessment of implant size were recorded. Implant size was compared with the manufacturers' guidelines based on body weight. Treatment‐associated complications and overall outcomes were also recorded.ResultsFourteen broken stems were reported in 13 dogs. Thirteen were size #5, #6, or #7 Biologic Fixation (BFX) lateral bolt stems and one was a size #5 standard BFX stem. A +9 head was used in 5 of 11 cases with 17 mm diameter heads. The median time from THA to stem breakage was 522 days (interquartile range, 330–905 days). Ten of the 14 stems were radiographically undersized. The weights of 10 of 13 dogs were at, or exceeded, weight‐limit guidelines. Eleven stems were revised with a new stem, two were explanted, and one was partially explanted. Major complications of revision included stem rebreakage, periprosthetic fracture, and pin and tension band‐fixation failure. Full function was achieved in 9 of 10 dogs with revised stems based on owner and surgeon assessment.ConclusionMost of the stems that broke were BFX lateral bolt stems and were undersized both radiographically and in comparison with weight‐limit guidelines. Revision can be successful, although the complication rate is high.Clinical significanceThe use of small, undersized BFX lateral bolt stems should be avoided.
“Mind-Muscle Connections”: Differential Associations Between Handgrip and Upper Body Strength With Cognitive Function in Young and Middle-Aged Adults
Authors: Baumgartner Nicholas W. , Geer Elyssa A. , Noh Kyoungmin , Khatri Rida A. , Lattyak Madelyn , Hirai Daniel M. , Amireault Steve , Kao Shih-Chun 
Published: February 2025

The relationship between muscle strength and cognition is widely studied in older adults; however, understanding this association at younger ages may help detect markers of early cognitive changes and inform future interventions. Accordingly, we aimed to identify relationships between handgrip, whole-body, upper body, and lower body strength and cognitive functions. A total of 112 adults (aged 18–50 years) completed comprehensive measures of muscle strength, aerobic capacity, body composition, and cognitive function. Hierarchical linear regressions revealed that individuals with stronger handgrip had better mental rotation performance (standardized β = 0.39); those with greater upper body strength had superior recognition (standardized β = 0.52) and pattern separation abilities (standardized β = 0.39), but whole- and lower body strength were not associated. Results demonstrate the unique relationship between upper body strength and aspects of cognitive function, in addition to differential associations of upper body and handgrip strength with encoding, retrieval, and spatial skills. The current findings establish an association between strength and cognitive function earlier than previously thought.
Teaching a 10-Step Risk Management Model: An Application of Kolb’s Experiential Learning Theory
Authors: Foster Susan B. , Miller John J. 
Published: February 2025

Sport management curricula at universities across the United States often require one or more classes on legal issues of sport. Most often, the topic of risk management (RM) is not covered as extensively as necessary with venues and events being targets of violence and terrorism. Do graduating sport management students understand RM in a way where they could bring a large toolbox of skills to an organization, especially if planning a career in facility/event management? To assist future sport managers, this article proposes an application of Kolb’s experiential learning theory to a comprehensive 10-step RM model. Each step in the model was carefully designed to create, deepen, and apply the RM process and exhibit the importance of including RM as a required course in a sport management curriculum. Applying Kolb’s experiential learning theory permits faculty to create an RM process to real-world systems.
Persistence and decay of neutralizing antibody responses elicited by SARS-CoV-2 infection and hybrid immunity in a Canadian cohort
Authors: Nouanesengsy Amy , Semesi Anthony , Quach Kim , Ivanochko Danton , Byrne Walter , Hwang Matthew , La Neve Maria-Rosa , Leon-Ponte Matilde , Litosh Alice , Wisener Nicole , Adeli Khosrow , Campigotto Aaron , Grunebaum Eyal , McGeer Allison , Moraes Theo J. , Sepiashvili Lusia , Upton Julia , Julien Jean-Philippe , Allen Upton 
Published: February 2025

ABSTRACT

A major challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has been assessing the intensity, dynamics, and determinants of the antibody responses after infection and/or vaccination. Therefore, we aimed to characterize the longitudinal dynamics of the antibody responses among naturally infected individuals and individuals who achieved hybrid immunity in a large Canadian cohort. We demonstrate that anti-Spike IgGs and neutralizing antibody dynamics vary greatly among individuals with COVID-19, in peak antibody levels, rate of waning, and longevity of the antibody response. Additionally, we found an association between robust antibody responses and individuals with severe COVID-19 clinical symptoms during the first-month post-symptom onset. For individuals who achieved hybrid immunity, a robust increase in anti-S1 IgGs and neutralizing antibodies followed the first vaccination dose; however, there was a minimal increase in the anti-S1 IgGs and neutralizing antibody titers after administration of the second dose of the vaccine. Furthermore, neutralizing antibodies elicited by the wild-type virus alone were largely ineffective against emerging variants of concern in our natural infection-only cohort, in contrast to a much broader and more robust neutralization profile observed in individuals who achieved hybrid immunity. Our findings emphasize the need for global SARS-CoV-2 vaccination efforts to further sustain protective immune responses required to minimize viral spread and disease severity in the population. As SARS-CoV-2 variants continue to emerge, understanding the interplay between previous infections, vaccine durability, and virus evolution will be critical for guiding ongoing vaccination strategies.

IMPORTANCE
A major challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has been assessing the intensity, dynamics, and determinants of the antibody response after infection and/or vaccination. Our paper addresses this in a large Canadian cohort with antibody responses that were generated by natural infection as well as vaccine in some persons studied.
Clostridioides
(
Clostridium
)
difficile
infection in hospitalized adult patients in Cambodia
Authors: Eng Lengsea , Collins Deirdre A. , Alene Kefyalew Addis , Bory Sotharith , Theng Youdaline , Vann Pisey , Meng Sreyhuoch , Limsreng Setha , Clements Archie C. A. , Riley Thomas V. 
Published: February 2025

ABSTRACT

Despite high levels of global concern, little is known about the epidemiology of
Clostridioides
(
Clostridium
)
difficile
infection (CDI) in Cambodia. This study aimed to identify the prevalence and risk factors for CDI, and molecular types of
C. difficile
in hospitalized adults at Calmette Hospital, Phnom Penh, Cambodia. Stool samples were collected from 263 hospitalized adults between June and September 2022 and tested for
C. difficile
using direct and enrichment cultures. PCR toxin genes
tcdA, tcdB, cdtA
, and
cdtB,
and amplification of the 16s–23s rRNA intergenic spacer region for ribotyping, were performed on all
C. difficile
isolates.
C. difficile
was isolated from 24% (63/263) of samples, and most isolates were non-toxigenic (67%, 42/63). The five most predominant toxigenic
C. difficile
ribotypes (RTs) were RTs 046 (8%, 5/63), 017 (6%, 4/63), 056 (5%, 3/63), 014/020 (5%, 3/63), and 012 (3%, 2/63), and prominent non-toxigenic RTs were QX011 (14%, 9/63), 010 (8%, 5/63), 009 (3%, 2/63), QX021 (3%, 2/63), and QX002 (3%, 2/63). Risk factors significantly associated with CDI included diabetes (odds ratio [OR] = 2.48, 95% confidence interval [CI]: 1.16–5.30) and hospitalization >24 h within the last 3 months before testing (OR = 3.89, 95% CI: 1.79–8.43). It was concluded that most participants from whom
C. difficile
was isolated were colonized only; however, a high prevalence of asymptomatic carriage could contribute to silent transmission in healthcare settings and communities. Genotypic identification of local
C. difficile
strains is necessary for a better understanding of the epidemiology of CDI and the importance of
C. difficile
.

IMPORTANCE

Clostridioides difficile
is a significant cause of diarrhea worldwide, initially as a hospital-acquired infection and, more recently, as a community-associated infection. Risk factors for hospital-acquired
C. difficile
infection include antimicrobial consumption, extended hospitalization, age ≥ 65 years, and proton pump inhibitor treatment. While much is known about
C. difficile
in high-income countries, little is known and there has been less interest in this infection in Asia due to the lack of data. Thus, investigating the prevalence and risk factors for
C. difficile
and characterizing
C. difficile
strains from hospitalized adults is necessary in Asian countries such as Cambodia. Diabetes and hospitalization >24 h within the last 3 months were identified as risk factors for
C. difficile
colonization/infection. The high prevalence of non-toxigenic strains and asymptomatic carriage of
C. difficile
in this country were notable. Further studies are warranted to gain better insights into this infection in Cambodia.
Patient-centred interprofessional education in cancer care: a scoping review protocol
Authors: Šerifović Adis , Fragner Tobias , Hama Honja , Kirchheiner Kathrin , Grabovac Igor 
Published: February 2025

IntroductionCancer remains a major global health challenge, affecting millions annually and ranking as the second leading cause of death worldwide. The complexity of cancer treatment requires an interdisciplinary approach, connecting professionals from various fields to deliver personalised and integrated care. However, structural issues and insufficient interdisciplinary training can impede effective collaboration, which is why effective interprofessional education (IPE) is needed. This protocol depicts the planned procedures for a scoping review that aims to explore the role of IPE in enhancing interdisciplinary collaboration within oncology by mapping and synthesising the implementation, impact and evaluation strategies of patient-centred IPE programmes.Methods and analysisThis scoping review will be conducted in line with the Joanna Briggs Institute guidelines for scoping reviews. The research team will develop a comprehensive search strategy and apply it to the following databases: CENTRAL, CINAHL, Embase, MEDLINE, PsycInfo, Scopus and Web of Science . Additionally, we will search for grey literature (eg, using OpenDOAR) and contact relevant organisations for pertinent reports. Each database will be searched without date restrictions on 11 September 2024. In the first stage, eligibility criteria will be assessed through a blinded title and abstract screening, followed by a full-text review. The research team will then extract and synthesise data related to the scoping review questions, focusing on implementation, impact and evaluation strategies employed in the included studies.Ethics and disseminationAs this protocol does not involve collecting primary data, ethical approval is not required. The results of this review will be published in a peer-reviewed journal and disseminated through institutional websites and conferences.
Interhospital transports and mortality in patients with critical COVID-19: a single-centre cohort study
Authors: Toss Agegård Lina , Berggren Karin , Cronhjort Maria , Joelsson-Alm Eva , Sackey Peter , Jonmarker Sandra , Schandl Anna Regina 
Published: February 2025

ObjectivesThis study aimed to compare mortality rates and length of hospital stay between patients with critical COVID-19 transferred to another hospital due to capacity constraints and those who remained at their initial admission hospital.DesignSingle-centre cohort study.Setting and participants665 patients were treated for SARS-CoV-2 at two intensive care units (ICUs) in Stockholm, Sweden, from 1 March 2020 to 30 June 2021. Data on interhospital transfers (IHTs) were retrieved from medical records and patient data management systems according to predefined protocols.Main outcome measuresThe outcomes were 30-day and 90-day mortality, days alive and out of ICU. HR with 95% CI were calculated using Cox proportional hazard models with adjustments for age, sex, body mass index, severity of illness, comorbidity, invasive ventilation, treatment limitations and pandemic waves.ResultsOf 665 patients, 133 (20%) were transferred to another hospital. The mortality rate of transferred patients compared with non-transferred patients at 30 days was 19% vs 26% (p=0.13) and at 90 days 26% vs 30% (p=0.43). In the adjusted Cox regression analysis, IHT was associated with a lower mortality risk at 30 days (HR 0.47, 95% CI 0.30 to 0.76) and 90 days (HR 0.52, 95% CI 0.34 to 0.79). However, the number of days alive and out of ICU was significantly lower for the IHT group at 30 days.ConclusionIn our study, IHT due to capacity constraints among critically ill COVID-19 patients was not associated with a higher mortality risk. The suitability for transfer was likely associated with lower mortality, although residual confounding cannot be ruled out. The requirement for invasive ventilation among transferred patients might account for the extended length of ICU stay, rather than the transfer itself. However, the difficulty in studying this issue lies in the fact that while patients are likely exposed to risks during transfer, they are simultaneously the patients stable enough to be transported.
Prevalence of pulmonary dysfunction and its risk factors in patients with transfusion-dependent thalassaemia: protocol for a systematic review and meta-analysis
Authors: Liang Xiao , Lu Yanfei , Huang Yumei , Pan Lingyuan , Wu Min , Lai Yongrong , Liu Rongrong 
Published: February 2025

IntroductionPulmonary complications frequently occur as comorbidities in individuals with transfusion-dependent thalassaemia (TDT). Despite their clinical significance, the existing literature lacks a systematic review and meta-analysis examining the prevalence and risk factors for pulmonary dysfunction in this patient cohort. Therefore, we propose to conduct a systematic review and meta-analysis to report the prevalence and associated risk factors of pulmonary dysfunction in TDT patients.Methods and analysisThis systematic review and meta-analysis will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines. We will search PubMed, EMBASE, the Cochrane Library, Scopus and Web of Science to identify English-language literature from the inception of each database up to 31 May 2024. We will include studies that involve TDT patients and report on the method of pulmonary function assessment, the proportion of pulmonary dysfunction and the analysis of risk factors for pulmonary dysfunction. The study designs included will be cohort, case-control and cross-sectional studies. Exclusions will apply to studies on non-TDT or patients with other diseases, reviews, case reports and animal experiments, as well as duplicated published studies, studies without full-text availability or studies from which raw data cannot be extracted. The screening process, including title, abstract and full texts, will be conducted independently by two reviewers. Data extraction will be performed following standardised protocols. The quality of the included studies will be assessed using the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality criteria. The meta-analysis will be conducted using Stata 14.0 and Review Manager (RevMan) 5.4 software, incorporating subgroup analyses, heterogeneity assessments and publication bias evaluations to ensure the robustness and reliability of the findings.Ethics and disseminationAs the data for this systematic review and meta-analysis are sourced exclusively from previously published literature, there is no requirement for ethical approval. The dissemination of the results will occur through publication in a peer-reviewed scholarly journal and presentations at relevant scientific conferences.PROSPERO registration numberCRD42024504353.