bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safe and Effective Treatment for Anemic Patients With Chronic Kidney Disease: An Updated Systematic Review and Meta-Analysis on Roxadustat
Authors: Tang Mei , Zhu Changyu , Yan Ting , Zhou Yanglin , Lv Qin , Chuan Junlan 
Published: July 2021

Background: Roxadustat is a new oral drug for anemia in chronic kidney disease (CKD). This study aimed to synthesize the evidence from randomized controlled trial (RCT)-based studies that estimated the efficacy and safety of roxadustat in anemia patients with non-dialysis-dependent (NDD) and dialysis-dependent (DD) CKD.Methods: We searched the PubMed, Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL) databases for related published studies. Moreover, we manually searched relevant pharmaceutical company websites and two international clinical trial registers to search for published and unpublished RCTs comparing roxadustat with erythropoietin-stimulating agents (ESAs) or placebo.Results: Fifteen RCTs (seven for DD-CKD patients, eight for NDD-CKD patients) were included in the meta-analysis, with 10,189 patients, 4,810 DD-CKD patients, and 5,379 NDD-CKD patients enrolled. Compared with ESAs (epoetin alfa or darbepoetin alfa) and placebo, roxadustat raised the hemoglobin level [weighted mean difference (WMD): 0.82 g/dL; 95% confidence interval (CI): 0.43–1.21], transferrin level (WMD: 0.5 g/L; 95% CI: 0.34–0.65), and TIBC level (WMD: 41.79 μg/dL; 95% CI: 38.67–44.92) and lowered the hepcidin level (WMD: −37.38 ng/ml; 95% CI: −46.63– −28.12) in both the DD-CKD and NDD-CKD patients with renal anemia. Roxadustat improved hemoglobin response and lowered the ferritin and TAST levels in the NDD-CKD patients but not in the DD-CKD patients. Furthermore, there was no difference between the treatment-emergent adverse events (TEAEs) of roxadustat and that of ESAs or placebo. But the incidence of serious TEAEs in the roxadustat group was significantly higher with NDD-CKD patients (OR: 1.15; 95% CI: 1.02–1.29).Conclusion: This study confirmed that roxadustat therapy could alleviate the anemia of DD-CKD and NDD-CKD patients by raising the hemoglobin level and regulating iron metabolism, but increased serious incidences of treatment-emergent adverse events (TEAEs) in NDD-CKD patients.
Systematic Review of the Economic Evaluation of Returning Incidental Findings in Genomic Research
Authors: Fontes Marx Mayara , Ataguba John E. , Vries Jantina de , Wonkam Ambroise 
Published: July 2021

Objectives: Discussions regarding who and how incidental findings (IFs) should be returned and the ethics behind returning IFs have increased dramatically over the years. However, information on the cost and benefits of returning IFs to patients remains scanty.Design: This study systematically reviews the economic evaluation of returning IFs in genomic sequencing. We searched for published articles on the cost-effectiveness, cost-benefit, and cost-utility of IFs in Medline, Scopus, PubMed, and Google Scholar.Results: We found six published articles that met the eligibility criteria of this study. Two articles used cost analysis only, one used cost-benefit analysis only, two used both cost analysis and cost-effectiveness, and one used both cost-benefit analysis and cost-utility to describe the cost of returning IFs in genomic sequencing.Conclusion: While individuals value the IF results and are willing to pay for them, the cost of returning IFs depends on the primary health condition of the patient. Although patients were willing to pay, there was no clear evidence that returning IFs might be cost-effective. More rigorous economic evaluation studies of IFs are needed to determine whether or not the cost of returning IFs is beneficial to the patient.
L’autorité personnelle selon Xénophon
Authors: Woronoff Michel 
Published: July 2021

Personal authority according to Xenophon
Xenophon’s personal experience, the reflections suggested to him by the Ten Thousand Mercenaries’ Retreat, his encounters with leaders of outstanding quality such as Cyrus the Younger or Agésilas have led the Master of the Scillonte estate to ponder the notion of authority by setting up examples and anecdotes to describe the ways of obedience and a leader’s naturel qualities. For him, power is essentially of military origin and there is no difference of nature between the authority of the master of an estate and that of an officer or a king ; it focuses responsibilities on one man because of his charisma. Those “royal personalities” of a military and not a tyrannical nature build their power only upon their value. This reflection on “the royal art of governing men” will ultimately lead to establishing the military ideology from which the first Hellenistic sovereigns will draw their legitimacy.
Les présages impériaux et le temps dans le De Vita Caesarum de Suétone
Authors: Vigourt Annie 
Published: July 2021

Les faits prodigieux, apparemment placés en vrac dans un ou deux chapitres de ses biographies des Césars, sont cependant très liés à la conception que Suétone avait du temps. Enumérés dans un ordre chronologique, les présages accumulés sont des «annonciations» répétées, à des époques privilégiées de la vie. Tous les instants ne sont pas égaux entre eux.
Pour Suétone, la vie humaine est la mesure du temps. L’homme peut déterminer le contenu historique d’un moment précis, mais tout effort pour modifier les instants limites — ceux de la mort, de l’échec — s’avère inefficace ; l’homme n’est pas maître du temps.
Le temps a une cohérence. Les présages déterminent un «avant» et un «après», ils découpent aussi des périodes pendant lesquelles les instants sont solidaires les uns des autres ; de plus, des liens également prodigieux unissent ces époques entre elles, et cela sans respecter une totale linéarité. Le temps, chez Suétone, a quelque analogie avec un labyrinthe.
ΔΥΝΑΣΤΕΙΑ chez Dion Cassius
Authors: Freyburger-Galland Marie-Laure 
Published: July 2021

In Cassius Dio’s Roman History, δυναστεία seems to be an equivalent of the Latin words potestas and sometimes potentia, with the classical meanings of “power” and “sovereignty” particulary when pertaining to barbarians or when used in the plural.
But there is a tendency for this word to express a special type of government, previously pointed to by Aristotle, an almost illegal and unconfessed monarchy or oligarchy.
Just as Polybius created a new type of government he called “ochlocracy” as a degenerate form of democracy, so the Severian writer resume the aristotelian type of dynasty.
Applying the Greek classification of the Roman reality of the end of the Republic, of the civil wars, triumvirates and “coups d’État” especially those of Caesar and Octavian, though generally regarded as a supporter of Augustan principate, Cassius Dio, when he uses the pejorative meanings of δυναστεία, appears rather critical towards the incipient imperial system.
PENGARUH STRATEGI PROMOSI DI SOCIAL MEDIA TERHADAP KEPUTUSAN PEMBELIAN HANDPHONE MEREK APPLE YANG DI MEDIASI WORD OF MOUTH MARKETING (Studi Kasus Pada Queeniphone Bengkulu)
Authors: Islamuddin Islamuddin , Depa Ray 
Published: July 2021

ABSTRACT The purpose of this study was to determine The Effect of Promotion Strategies in Social Media toward Apple Brand Mobile Purchasing Decisions Mediated by Word of Mouth Marketing on Queen iphone Bengkulu. This research used survey research methods with quantitative data analysis by using the MSI method (method of successive interval) to transform ordinal scale data into interval scale data. The population of this study were all of consumers who buy Apple Brand Mobile products on Queeniphone Bengkulu. The results of this study know that there were significant effect toward Apple Brand Mobile Purchasing Decisions Mediated by Word of Mouth Marketing on Queen iphone Bengkulu. It is better for owner of Queen iphone Bengkulu to maintain and even improve consumer purchasing decisions by using variuos promotion strategy. Keywords: Promotion strategy, word of mouth marketing, purchasing decisions.
PENERAPAN TERAPI SELF-DISCLOUSURE PADA REMAJA YANG MENGALAMI STRES
Authors: Yani Sutri , Nilawati Iin 
Published: July 2021

Self-disclosure therapy is stress therapy through self-disclosure, which is the activity of sharing familiar feelings with others through telling stories, communicating deeply, and allowing themselves to be known by others. The ability to express oneself, such as feelings and thoughts, to others is recognized as important. This study aims to determine the effect of self-disclosure therapy on adolescents who experience stress on reducing stress levels. This study used a quasi experimental design. The sample in this study were teenagers, amounting to 29 respondents. In this study, respondents were given a pre-test before being given self-disclosure therapy. Then the respondent is given self-disclosure therapy. After being given therapy, the respondent is given a post test, then the stress level is measured. The results showed that there was an effect of self disclosure on adolescents who experienced stress. This can be seen from the mean stress level before self-disclosure therapy, the mean stress level (24.31) and after the self-disclosure therapy, the mean stress level (16.34). The results of statistical tests using the Man-Wilney test showed that the P value = 0.000, which means that there is a significant effect of providing self-disclosure therapy on reducing stress levels in adolescents who experience stress. It is hoped that self-disclosure therapy can be used as an alternative therapy to reduce stress levels in adolescents. Keywords: Self Disclousure; Stress; Adolescencts
HUBUNGAN KOMUNIKASI TERAPEUTIK DAN POLA MAKAN DENGAN KEJADIAN GASTRITIS DI PUSKESMAS UJUNG KARANG BENGKULU TENGAH
Authors: ANDARI FATSIWI NUNIK , Yulianda Yuni 
Published: July 2021

Gastritis is one of the diseases that need more attention. Uncaring gastritis would affect the occurrence of bleeding in the gastrointestinal tract, ulcers, perforation, and anemia. The purpose of this study was to determine the relationship between therapeutic communication and dietary habits with the incidence of gastritis in the Public Health Centre of Ujung Karang, Bengkulu Tengah. This research was a quantitative study with a case-control design. The total sample was 140 patients that were divided into two groups: 70 respondents were in the case group and 70 respondents were in the control group. The results of this study indicate that 60,7% of respondents received a good communication therapeutic and 39,3% of respondents stated the communication therapeutic was poor. Based on eating habits, 62,1% had a regular diet on the eating frequency and 37,9% was not. For the type of food consumed by the respondents, 41,4% of respondents had consumed unhealthy food. Based on the chi-square statistical test, there was a significant correlation between therapeutic communication and eating habits with the incidence of gastritis. Keywords: eating habits, gastritis, therapeutic communication
INTERVENSI NON-FARMAKOLOGIS PEMENUHAN KEBUTUHAN PSIKOSOSIAL PADA LANSIA: SEBUAH KAJIAN LITERATUR
Authors: Komariah Maria , Pratiwi Zulfa Syafiyah , Budhiyani Hanny , Adithia Andi 
Published: July 2021

The physical changes that occur in the elderly are closely related to their psychosocial changes. The effects that arise due to various changes in the elderly, if not properly resolved, tend to affect the overall health of the elderly. The purpose of this literature review is to identify interventions to meet the psychosocial needs of the elderly. Researchers conducted the review and search on several search engines such as Pubmed, EBSCO. After sorting using the specified keywords, inclusion, and exclusion criteria, four articles were obtained that were appropriate and used in the literature study. The results of the literature review found several types of non-pharmacological interventions to meet the psychosocial needs of the elderly, namely horticultural therapy, physical exercise and listening to the Al-Qur'an, group work, and dance movement interventions. Keywords: elderly, interventions, needs, psychosocial
Model Aktivitas Online Learning di Perguruan Tinggi pada Masa Pandemi COVID-19
Authors: Noprisson Handrie 
Published: July 2021

Penelitian ini bertujuan untuk mengusulkan model konseptual aktivitas online learning di perguruan tinggi pada masa pandemi COVID-19. Model ini dibangun dengan menganalisis kondisi pengguna, proses dan teknologi yang digunakan pembelajaran online selama pandemi COVID-19. Penelitian ini terdiri dari tahapan pengumpulan data, identifikasi aktvitas online learning selama pandemi COVID-19, pemetaan aktivitas terhadap dimensi model dan perancangan model konseptual online learning selama pandemi COVID-19. Data penelitian didapatkan dari database penelitian seperti PubMed, ProQuest, Science Direct, Google Scholar, IEEE Xplore dan Wiley Online Library. Hasil dari penelitian adalah model konseptual aktivitas online learning dengan komponen model terdiri dari people (mahasiswa, pengajar dan staf akademik), process (learning/cognitive process, pengaturan diri dalam belajar/student self regulation, interaksi manusia), technology (learning management system, interaction support tools, komputer/smartphone dan internet).Penelitian ini bertujuan untuk mengusulkan model konseptual aktivitas online learning di perguruan tinggi pada masa pandemi COVID-19. Model ini dibangun dengan menganalisis kondisi pengguna, proses dan teknologi yang digunakan pembelajaran online selama pandemi COVID-19. Penelitian ini terdiri dari tahapan pengumpulan data, identifikasi aktvitas online learning selama pandemi COVID-19, pemetaan aktivitas terhadap dimensi model dan perancangan model konseptual online learning selama pandemi COVID-19. Data penelitian didapatkan dari database penelitian seperti PubMed, ProQuest, Science Direct, Google Scholar, IEEE Xplore dan Wiley Online Library. Hasil dari penelitian adalah model konseptual aktivitas online learning dengan komponen model terdiri dari people (mahasiswa, pengajar dan staf akademik), process (learning/cognitive process, pengaturan diri dalam belajar/student self regulation, interaksi manusia), technology (learning management system, interaction support tools, komputer/smartphone dan internet).
PENGARUH KECERDASAN LOGIS MATEMATIS TERHADAP KEMAMPUAN PENALARAN MATEMATIS SISWA SMP NEGERI 23 MUARO JAMBI
Authors: Relawati Relawati 
Published: July 2021

Penelitian ini dilatarbelakangi oleh rendahnya kemampuan penalaran matematis siswa kelas VIII SMP Negeri 23Muaro Jambi. Adapun tujuan dari penelitian ini adalah untuk mengetahui adakah pengaruh kecerdasan logis matematis terhadap kemampuan penalaran matematis siswa kelas VIII SMP Negeri 23 Muaro Jambi. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kuantitatif dengan jenis penelitian korelasional. Populasi pada penelitian ini adalah siswa kelas VIII SMP Negeri 23 Muaro Jambi. Pengumpulan data menggunakan tes kecerdasan logis matematis sebanyak 4 item soaldan tes kemampuan penalaran matematis sebanyak 4 item soal. Berdasarkan hasil analisis data, penelitian ini menunjukkanterdapat pengaruh yang positif dan signifikan antara kecerdasan logis matematis terhadap kemampuan penalaran matematis siswa kelas VIII SMPN 23 Muaro Jambi.Kata kunci: kecerdasan logis, kemampuan penalaran matematis.
Solusi Terhadap Problematika PAI di Sekolah
Authors: Aulia Ninda 
Published: July 2021

Tujuan penelitian ini untuk menggali secara teoritik dan mendalam mengenai Implementasi Teori Pembaharuan Pendidikan Islam menurut Harun Nasution terhadap problematika PAI di Sekolah. Penelitian ini menggunakan metode penelitian literature atau library research. Hasil Penelitian ini diperoleh bahwa Teori Pembaharuan Pendidikan Islam menurut Harun Nasution tentang pembaharuan Pendidikan Islam sangat mempengaruhi bagaimana tumbuh kembangnya pendidikan Islam di Indonesia dari tingkat sekolah/madrasah hingga tingkat Perguruan Tinggi. Dari pemikiran Harun Nasution lahirlah demokrasi pendidikan yang merubah tatanan kelembagaan menjadi lebih terbuka dan model pembelajaran yang tidak monoton serta lebih mengembangkan kemampuan intelektual siswa maupun mahasiswa. Solusi dari Problematika PAI di Sekolah adalah; 1) mengajarkan penerapan nilai-nilai praktik Agama Islam dalam kehidupan sehari-hari dan menekankan nilai-nilai Agama dalam setiap kegiatan yang dilakukan baik dilingkungan sekolah maupun diluar lingkungan sekolah, diadakan pemisahan dan pengelompokan peserta didik berdasarkan tingkat kemampuan dan kefahaman yang sama. 2) pendidik harus selalu meningkatkan kualitas diri dengan terus mengembangkan potensi yang dimiliki dengan cara berperan serta dalam setiap pengembangan dan penerapan praktik agama Islam di lingkungan sekolah utamanya dan lingkungan masyarakat sekitar sehingga benar-benar bisa menjadi pendidik yang sebenarnya dengan meneladani cara mendidik Rasulullah SAW. 3) Membentuk lingkungan sekolah yang benar-benar menerapkan nilai-nilai Islam, berusaha untuk memperbaiki manajemen dengan cara menyadarkan pihak yang mengelola manajemen tentang pentingnya dan kewajiban memberikan pelayanan pelayanan Pendidikan Agama Islam yang memadai untuk peserta didik, Pemberdayaan semua pihak terkait atau stakeholder untuk ikut mengatasi kekurangan sarana dan prasarana di sekolah.
Cárie na infância: epidemiologia, etiologia e prevenção.
Authors: Bozano de Souza Pâmela , Benitez de Paula Francisca Carla 
Published: July 2021

A cárie na primeira infância (CPI) é uma das doenças mais prevalentes em crianças em todo o mundo. A CPI é impulsionada por um estado disbiótico dos microrganismos orais causado principalmente por uma dieta rica em açúcar. Além disso, a má higiene oral ou a remoção insuficiente da placa dentária levam à rápida progressão da CPI. A CPI não só leva à destruição dentária e dor nas crianças, mas também afeta a qualidade de vida dos cuidadores. Crianças com CPI extensa apresentam alto risco de desenvolver cárie com a dentição permanente ou terão outros problemas para falar e / ou comer. Para prevenir a CPI, várias estratégias devem ser levadas em consideração. As crianças devem escovar os dentes com dentifrícios que contenham ingredientes suaves, como surfactantes suaves e agentes que apresentem propriedades antiaderentes em relação aos microrganismos orais. Os pais / responsáveis ​​devem ajudar seus filhos a escovar os dentes. Além disso, agentes remineralizantes e não tóxicos devem ser incluídos na formulação do creme dental. Dois agentes biomiméticos promissores para higiene bucal de crianças são fosfato de cálcio amorfo [Cax (PO 4 ) y n H 2 O] e hidroxiapatita [Ca 5 (PO 4 ) 3 (OH)].
APPLICATION OF MODERN INFORMATION TECHNOLOGIES IN AUTOMATION OF MACHINERY PRODUCTION
Authors: Суворов А.П. , Алешина А.Э. , Сафонова Т.П. 
Published: July 2021

Актуальность исследования обоснована расширением функциональных возможностей современных систем автоматизированного проектирования, которые включают в себя не только средства автоматизации большей части жизненного цикла изделия, но и применение облачных технологий, что существенно расширяет возможности их применения. В связи с этим статья направлена на раскрытие особенности применения современных средств автоматизированного проектирования и аддитивных технологий для изготовления сложных деталей или элементов конструкций в условиях единичного и опытного производства, когда необходимо проведение теоретических и экспериментальных исследований на основе проектирования и разработки сложнопрофильного электрод-инструмента для электрических методов обработки. В статье представлен метод проектирования и производства электрода-инструмента для электрических методов обработки с последующим нанесением токопроводящего покрытия, с использованием современных систем автоматизированного проектирования в опытно-конструкторском и единичном производстве. Материалы статьи представляют практическую ценность для предприятий машиностроительного комплекса, так как позволяют производить изменения технологии проектирования и изготовления сложных деталей или элементов конструкций. За счет применения современные системы автоматизированного проектирования и аддитивные технологии, что снижает себестоимость и повышает вариативность его применения
The relevance of the study is justified by the expansion of the functionality of modern automated design systems, which include not only automation tools for most of the product life cycle but also the use of cloud technologies, which significantly expands the possibilities of their application. In this regard, the article is aimed at disclosing the features of the use of modern means of automated design and additive technologies for the manufacture of complex parts or structural elements in a single and pilot production, when it is necessary to conduct theoretical and experimental research based on the design and development of a complex-profile electrode-tool for electrical processing techniques. The article presents a method for designing and producing a tool-electrode for electrical processing methods, followed by the application of a conductive coating, using modern computer-aided design systems in experimental design and unit production. The materials of the article are of practical value for enterprises of the machine-building complex since they allow making changes in the design technology and manufacturing of complex parts or structural elements. Through the use of modern computer-aided design systems and additive technologies the cost reduces and the variability of its application increases
MOTIVASI GURU-GURU PAUD DALAM MELANJUTKAN BELAJAR/PERKULIAHAN PADA S1 PROGRAM STUDI PENDIDIKAN GURU PAUD DI KABUPATEN KEBUMEN
Authors: Andika Alek , Hambali Habib 
Published: July 2021

Penelitian ini bertujuan untuk: 1. Mendapatkan gambaran/diskripsi motivasi dan perilaku para guru PAUD yang sudah mengajar dan mau melanjutkan kuliah S1 pada Program PAUD. 2. Mengetahui gambaran secara umum bahwa mahasiswa Prodi PAUD. 3. Menggali informasi terkait hubungan antara motivasi kuliah guru PAUD dengan kendala/tanggung jawab mereka menjadi seorang mahasiswa. Penelitian ini dilakukan pada guru PAUD yang sedang melanjutkan studi S1 PAUD di Kabupaten Kebumen. Sedangkan metode penelitian yng digunakan adalah kualitatif dengan melakukan pengumpulan data (Collecting data)yang diperoleh dari Dinas Pendidikan Kabupaten Kebumen tahun 2020 melalui 3 cara yaitu wawancara, observasi dan studi dokumentasi. Selanjutnya peneliti beserta Tim melakukan analisis data penelitian yang telah diperoleh melalui 3 langkah yaitu (reduksi, penyajian data dan penarikan kesimpulan). Setelah peneliti melakukan langkah-langkah penelitian diatas, peneliti menemukan kesimpulan sebagai berikut: 1. Gambaran secara umum bahwa mahasiswa Prodi PAUD di Kabupaten Kebumen sudah mengajar di instansi /lembaga masing-masing, sebagian besar dari mereka berpendidikan SLTA dan rata-rata berusia 30 tahun keatas. 2. Beberapa motivasi guru PAUD dalam memutuskan untuk lanjut kuliah adalah (menambah wawasan keilmuan dan adanya harapan peningkatan kesejahteraan setelah mendapatkan gelar sarjana). 3. Diskripsi dampak positif dan pengaruh yang muncul dimasyarakat adalah adanya stigma bahwa usia dan kesibukan tidaklah menjadi penghalang bagi seseorang untuk menuntut ilmu.