bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microglia and Fn14 regulate transcription and chromatin accessibility in developing neurons
Authors: Ferro Austin , Vrudhula Uma , Auguste Yohan S.S. , Cheadle Lucas 
Published: August 2021

AbstractCytokine signaling pathways that promote inflammation in peripheral tissues are repurposed to coordinate the refinement of synaptic connections in the developing brain. However, the downstream mechanisms through which these pathways mediate neural circuit maturation remain to be fully defined. Here, we demonstrate that Fn14, a cytokine receptor that promotes inflammation outside of the central nervous system, shapes the transcriptional profiles and chromatin landscapes of neurons in the developing brain. Single-nucleus RNA-sequencing revealed hundreds of misregulated genes in the thalamocortical neurons of the visual thalami of mice lacking either Fn14 or its microglial derived cytokine ligand TWEAK, including genes encoding proteins with critical roles in synaptic function, histone modification, and chromatin remodeling. Whole-genome analysis uncovered significant alterations in chromatin accessibility in the brains of mice lacking Fn14 or in wild-type mice following microglial depletion, and chromatin changes due to both manipulations were enriched near genes encoding regulators of synaptic function. Loss of microglia also led to the retention of excess synapses, suggesting that microglia may link modifications in neuronal chromatin to the functional refinement of neural circuits. Consistent with Fn14 shaping brain function beyond the visual system, Fn14 knockout mice displayed impairments in memory task proficiency as well as heightened sensitivity to pharmacologically induced seizures. Taken together, these results define a previously undescribed interaction between microglia, cytokine signaling, and the neuronal epigenome that is likely to contribute to neural circuit refinement and function in the brain.
Age-related susceptibility of ferrets to SARS-CoV-2 infection
Authors: Martins Mathias , Fernandes Maureen H.V. , Joshi Lok R. , Diel Diego G. 
Published: August 2021

AbstractSusceptibility to SARS-CoV-2 and the outcome of COVID-19 have been linked to underlying health conditions and the age of affected individuals. Here we assessed the effect of age on SARS-CoV-2 infection using a ferret model. For this, young (6-month-old) and aged (18-to-39-month-old) ferrets were inoculated intranasally with various doses of SARS-CoV-2. By using infectious virus shedding in respiratory secretions and seroconversion, we estimated that the infectious dose of SARS-CoV-2 in aged animals is ∼32 plaque forming units (PFU) per animal while in young animals it was estimated to be ∼100 PFU. We showed that viral replication in the upper respiratory tract and shedding in respiratory secretions is enhanced in aged ferrets when compared to young animals. Similar to observations in humans, this was associated with higher expressions levels of two key viral entry factors - ACE2 and TMPRSS2 - in the upper respiratory tract of aged ferrets.
Influence of tab corner geometry on supersonic jets
Authors: Quadros Jaimon Dennis , Khan S.A. , R. Hanumantharaya 
Published: August 2021

Purpose
The purpose of this study is to evaluate the effect of tabs having different corner geometries on the flow characteristics of a supersonic convergent–divergent (C-D) nozzle.

Design/methodology/approach
A circular C-D nozzle of Mach 2.0 was used, and the tabs were positioned at the exit of the nozzle in diametrically opposite directions. Three tabs having different corner geometry implemented in the experiments were rectangular tab with triangular top edge, triangular tab with a bell-shaped edge and tapered tab. The pressure profiles across the tabs and the centerline pressure decay along the jets were measured. The shadowgraph technique illustrated the waves present in the center of an oncoming jet. The nozzle pressure ratios (NPR) were varied from 4 to 8, in the steps of one, covering various overexpansion and under expansion levels at the exit of the nozzle.

Findings
The results showed tapered tabs act as a better mixing promoter than the other tabs used in the study. A reduction of 91.25% in core length for NPR 8 was observed for the tapered tabs. Subsequently, core length reductions generated by triangular tabs with a bell-shaped top edge were 87.5%, and those caused by rectangular tabs with a triangular top edge were 7.5%.

Practical implications
The research results could be used for designing combustion chambers and chemical reactors that require jets to enhance mixing levels.

Originality/value
The tabs having three different corners geometries, i.e. sharp or pointed, bell-shaped and straight edge has never been investigated before. The idea of only modifying corners is the innovative step of this research.
Numerical computation for entropy generation in Darcy-Forchheimer transport of hybrid nanofluids with Cattaneo-Christov double-diffusion
Authors: Nayak Manoj Kumar , Shaw Sachin , Waqas H. , Muhammad Taseer 
Published: August 2021

Purpose
The purpose of this study is to investigate the Cattaneo-Christov double diffusion, multiple slips and Darcy-Forchheimer’s effects on entropy optimized and thermally radiative flow, thermal and mass transport of hybrid nanoliquids past stretched cylinder subject to viscous dissipation and Arrhenius activation energy.

Design/methodology/approach
The presented flow problem consists of the flow, heat and mass transportation of hybrid nanofluids. This model is featured with Casson fluid model and Darcy-Forchheimer model. Heat and mass transportations are represented with Cattaneo-Christov double diffusion and viscous dissipation models. Multiple slip (velocity, thermal and solutal) mechanisms are adopted. Arrhenius activation energy is considered. For graphical and numerical data, the bvp4c scheme in MATLAB computational tool along with the shooting method is used.

Findings
Amplifying curvature parameter upgrades the fluid velocity while that of porosity parameter and velocity slip parameter whittles down it. Growing mixed convection parameter, curvature parameter, Forchheimer number, thermally stratified parameter intensifies fluid temperature. The rise in curvature parameter and porosity parameter enhances the solutal field distribution. Surface viscous drag gets controlled with the rising of the Casson parameter which justifies the consideration of the Casson model. Entropy generation number and Bejan number upgrades due to growth in diffusion parameter while that enfeeble with a hike in temperature difference parameter.

Originality/value
To the best of the authors’ knowledge, this research study is yet to be available in the existing literature.
Invoking embeddedness and cybernetic theories for evaluating the national open government data portal of India
Authors: Saxena Stuti 
Published: August 2021

Purpose
The purpose of this paper is to present an evaluation of the national Open Government Data (OGD) portal of India (www.data.gov.in) and underline the significance of maintaining the quality of the data sets published online.

Design/methodology/approach
The research approach bases itself on the adapted version of embeddedness theory and cybernetic model apart from the data sets–usability framework proposed in recent literature (Machova et al., 2018).

Findings
Findings from this study indicate that OGD initiative needs to be embedded in the social fabric of the country to ensure that the data sets are being reused by a myriad set of stakeholders for deriving social and economic value. Likewise, the linkages between the stakeholders (for instance, government, citizens, non-governmental bodies, private sector, etc.) should be fortified to enable the reuse of the data sets in an appropriate manner.

Originality/value
Maintenance of quality of the data sets holds paramount importance. Implicitly, efforts should be made on the part of all the stakeholders concerned that the data sets be qualitatively and quantitatively adequate. This paper concludes with limitations and further research pointers.
The effects of cruise attributes on impulse buying behavior: the mediating role of impulsive buying tendency
Authors: Kwon Jookyung , Ahn Jiseon 
Published: August 2021

Purpose
This study aims to examine the effects of cruise attributes on impulse buying of service customers through impulsive buying tendency. Specifically, this study investigates whether service attributes (variety of selection and price) influence the impulsive buying behavior of customers by stimulating their impulsive buying tendency.

Design/methodology/approach
Partial least squares-structural equation modeling was used to test the hypothesis using a sample of 143 cruise customers. Mediating analysis was conducted to examine whether customer personal traits (impulsivity) mediated the relationship between service attributes and impulsive buying behavior.

Findings
The findings showed that price attributions had a significant positive direct impact on impulsive buying tendency and behavior, while a variety of selections had a significant direct effect on impulse buying behavior. The results revealed a significant mediating role of impulsive buying tendency in the relationship between price attributions and impulse buying.

Originality/value
Although studies on the decision-making style of service customers have been widely discussed, a limited number of studies has examined customers’ impulsive buying behavior in the service sector. Considering the importance of impulsive purchasing as a valuable marketing tool, the results of this study can help service providers and researchers enhance their knowledge of the mechanism of impulse buying behavior.
Happier and greener? The relationship between subjective well-being and environmental performance
Authors: Toigo Camila Horst , de Mattos Ely José 
Published: August 2021

PurposeThe purpose of this paper is to investigate, at a national scale, how self-reported happiness varies with the different levels of environmental conditions resulting from national policies, while also considering different levels of freedom.Design/methodology/approachThe authors estimated the effects of environmental performance on happiness using the log-log regression model presented.FindingsEnvironmental performance is shown to have a direct impact on happiness. Nonetheless, the explanatory influence of freedom is only significantly positive for free countries, where the institutional and political arrangements are better established and thereby the effective democracy is more solid.Originality/valueThis article offers insights into happiness levels within the context of the current clamour for environmental protection and more sustainable development goals.
The role of flow consciousness in consumer regret
Authors: Barta Sergio , Gurrea Raquel , Flavián Carlos 
Published: August 2021

PurposeThis research aims to identify whether subsequent consciousness of having been in a flow state – that is, flow consciousness – regarding an earlier impulse purchase affects consumers' post–purchase behaviours, specifically their feelings of consumer regret.Design/methodology/approachThe study applied a mixed methodology. First, the authors conducted two qualitative studies (focus groups) to establish the relationships between flow, flow consciousness and regret. Second, the authors conducted a quantitative study using data collected through an online questionnaire. Participants were asked to recall a recent shopping experience. To conduct confirmatory factor analysis, the authors gathered data from 304 consumers who had searched for, and purchased, a product on Amazon (www.amazon.com). Structural equation modelling, based on covariance, was used to test the hypotheses.FindingsFlow consciousness is found to reduce consumer regret after an impulse purchase.Practical implicationsOnline retailers should make consumers aware of the flow state they have experienced. Flow states lead to increased impulse buying, and if consumers are made aware that they were in a flow state, it may reduce any regret they feel after the purchase.Originality/valueThis is the first study to examine the effects of flow consciousness on consumer behaviour after an impulse purchase. In particular, research has not analysed the effects that flow consciousness has on negative feelings experienced after the impulse purchase of a product.
A comparison of global suicide terrorism by region before and after 9/11 terrorist attacks
Authors: Guler Ahmet , Demir Mustafa 
Published: August 2021

Purpose
This study aims to examine the effect of the 9/11 terrorist attacks on suicide terrorism in different regions of the world and changes in the trends in suicide terrorism according to regions before and after 9/11.

Design/methodology/approach
Using the data obtained from the Global Terrorism Database from 1981 to 2019, the descriptive statistics were computed first and then, independent samples t-tests were run to compare the monthly mean percentage of suicide-terrorism incidents that occurred in each region between the pre-9/11 and the post-9/11 periods. Finally, to statistically assess the effect of the 9/11 attacks and changes in the trends for the dependent variables over time, monthly interrupted time-series analyzes were conducted.

Findings
The results of monthly interrupted time series analyzes showed that after the 9/11 attacks, the trends for suicide-terrorism rates decreased significantly in three regions including South Asia, the Middle East and North Africa and Europe, while the trend for suicide-terrorism rates increased significantly in Sub-Saharan Africa. However, no statistically significant changes in the trends in suicide-terrorism rates occurred in three regions including North America, East Asia and Central Asia and Southeast Asia before 9/11, during November 2001 or after 9/11.

Originality/value
This study indicates the critical importance of the 9/11 terrorist attacks in suicide terrorism and its impact on these events in different regions of the world. The research also provides some recommendations concerning the effectiveness of defensive and offensive counterterrorism policies against suicide terrorism.
Preservation for diverse users: digital preservation and the “Designated Community” at the Ontario Jewish Archives
Authors: Moles Nathan 
Published: August 2021

PurposeConventional approaches to digital preservation posit that archives should define a Designated Community, or future user group, for whom they preserve digital information. Archivists can then use their knowledge of these users as a reference to help them deliver digital information that is intelligible and usable. However, this approach is challenging for archives with mandates to serve wide and diverse audiences; these archives risk undermining their efforts by focusing on the interests of a narrow user group.Design/methodology/approachA unique approach to this challenge was developed in the context of a project to build a digital preservation program at the Ontario Jewish Archives (OJA). It draws from previous research on this topic and is based on a combination of practical and theoretical considerations.FindingsThe approach described here replaces the reference of a Designated Community with three core components: a re-articulation of the Open Archival Information System (OAIS) mandatory responsibilities; the identification of three distinct tiers of access for digital records; and the implementation of an access portal that allows digital records to be accessed and rendered online. Together with supplemental shifts in reference points, they provide an alternative to the concept of a Designated Community in the determination of preservation requirements, the identification of significant properties, the creation of Representation Information and in the evaluation of success.Originality/valueThis article contributes a novel approach to the ongoing conversation about the Designated Community in digital preservation, its application and its limitations in an archival context.
New developments in financial economics
Authors: Willett Thomas D. 
Published: August 2021

Purpose
This study aims to critically review recent contributions to the methodology of financial economics and discuss how they relate to one another and directions for further research.

Design/methodology/approach
A critical review of recent literature on new methodologies for financial economics.

Findings
Recent books have made important contributions to the study of financial economics. They suggest new approaches that include an emphasis on radical uncertainty, adaptive markets, agent-based modeling and narrative economics, as well as extensions of behavioral finance to include concepts such as diagnostic expectations. Many of these contributions can be seen more as complements than substitutes and provide fruitful directions for further research. Efficient markets can be seen as holding under particular circumstances. A major them of most of these contributions is that the study of financial crises and other aspects of financial economics requires the use of multiple theories and approaches. No one approach will be sufficient.

Research limitations/implications
There are great opportunities for further research in financial economics making use of these new approaches.

Practical implications
These recent contributions can be quite useful for improved analysis by researchers, private participants in the financial sector and macroeconomic and regulatory officials.

Originality/value
Provides an introduction to these new approaches and highlights fruitful areas for their extensions and applications.
Sharīʿah non-compliant income disclosures and the moral legitimacy strategies of Islamic banks
Authors: Che Azmi Anna , Rosman Romzie , Omar Normah 
Published: August 2021

Purpose
The purpose of this study is to understand the reasons behind the different patterns of Sharīʿah non-compliant income (SNCI) disclosures amongst Islamic banks and, in particular, the extent to which Islamic banks make SNCI disclosures. The process involved in gaining and maintaining moral legitimacy forms the framework for this study.

Design/methodology/approach
Interviews were conducted with managers of Islamic banks involved in the reporting of SNCI in company annual reports.

Findings
The interview findings show that Islamic banks prefer to use procedures to gain and enhance moral legitimacy amongst their customers, business partners and staff. The constraints and challenges that Islamic banks face in SNCI reporting make this a popular means of securing moral legitimacy. However, these practices may not lead to enhanced and more communicative SNCI disclosures by Islamic banks.

Originality/value
To the best of the authors’ knowledge, this is the first study that explains the motivations behind SNCI reporting by Islamic banks and frames these motivations under the moral legitimacy framework.
The adoption of biometric point-of-sale terminal for payments
Authors: Sulaiman Siti Nurdiyana Atikah , Almunawar Mohammad Nabil 
Published: August 2021

Purpose
The purpose of this paper is to investigate factors that influence customers’ adoption of biometric-based point-of-sale in Brunei.

Design/methodology/approach
This paper extends technology acceptance model constructs with trust and some other variables as the framework to investigate their influence on the attitude toward the usage of a biometric point-of-sale terminal for payments in Brunei. Nine variables may influence user’s perception toward usage. The nine variables are needed, perceived ease of use, perceived usefulness, experience, innovativeness, privacy, security, trust and attitude toward usage. Multiple regression analysis was conducted to test hypotheses related to these nine variables.

Findings
It is found that the innovativeness of an individual and similar experience corresponds toward trust, which is positively related to attitude toward usage. Perceived usefulness and trust have significantly influenced the intention of individuals to use biometrics as an authentication method for payment.

Research limitations/implications
The nature of this research is to gather the public’s opinion and perception as much as it is deemed possible to get a bigger and clearer picture of the study. As the target respondence is citizens and residents of Brunei without any specification or exclusion, a large response would be needed to have a more reliable and accurate result. However, only 205 respondents can be gathered in this study. Had there been a longer time frame, it would be best to gather a lot more responses.

Originality/value
This paper explores the adoption of biometric authentication in large-scale point-of-terminals. It identifies factors that influence adoption. The results of this study could assist future researchers in which direction to take to further explore biometric as an authentication method for payment. In addition to this, it could also provide banks and financial technology in Brunei a clearer picture of the Brunei market and Bruneians perspective on the biometric system.
Can technological innovation spur economic development? The case of Indonesia
Authors: Junarsin Eddy , Hanafi Mamduh Mahmadah , Iman Nofie , Arief Usman , Naufa Ahmad Maulin , Mahastanti Linda , Kristanto Jordan 
Published: August 2021

Purpose
Innovation in digital technologies has been the main force in promoting growth and inclusion. However, the impact of such innovations remains ambiguous. Within this context, this study aims to analyze the distribution of digitally empowered peer-to-peer (P2P) lending in Indonesia.

Design/methodology/approach
This study uses a quantitative approach to estimate the impact of technological innovation in promoting economic development. In particular, this study employs empirical panel data from 135 financial technology (FinTech) companies from 2015 to 2019 and use the dynamic panel threshold regression approach. This study collects secondary data to build the estimated model.

Findings
Contrary to conventional wisdom, this study’s evidence suggests that there is a delayed effect between the contribution of P2P lending by FinTech firms on economic growth in the country. While the immense growth of FinTech seems promising, the findings indicate that FinTech is far from its optimal point. This study calculates the optimal combination between productive and consumptive lending and between Java and non-Java. In view of this finding, this study proposes strategies to effectively distribute lending and bring about the expected benefit to the economy.

Practical implications
Since the contribution of P2P lending on economic development has not reached its optimum, the findings expose the limitation of current technological innovation in the financial sectors. In this sense, P2P penetration on the financing market needs encouragement. The calculations for optimal allocation between productive and consumptive and between Java and non-Java provide guidance to policymakers. This study helps practitioners to shape strategy and to begin experimenting with different approaches to distribute loans effectively.

Originality/value
To the best of the authors’ knowledge, there are no empirical studies that examine the impact of emerging FinTech companies in promoting economic growth and financial development. The findings close this research gap, especially in regard to innovation management literature, and provide insights for practitioners, policymakers and regulators.