bluuebunny/crossref_metadata_2025_split huggingface dataset:
KOMPOSISI KIMIA DAN NILAI SENSORIK STIK IKAN TUNA (Thunnus sp.) DENGAN PENAMBAHAN TEPUNG BUAH MANGROVE (Bruguiera gymnorrhiza)
Authors: Dina Dina , Asnani Asnani , Rejeki Sri 
Published: October 2021

Chemical Composition and Sensoric Value of Tuna Fish Sticks (Thunnus sp.) with Addition of Mangrove Flour (Bruguiera gymnorrhiza)ABSTRACT This study aims to determine the effect of the addition of mangrove flour to sensory properties and water content and protein content of tuna sticks. This study used a Completely Randomized Design (CRD) with a combination of the use of fish meat and mangrove flour (from total stick ingredients) in a row: 50: 0% (I50M0), 45: 5% (I45M5), 40:10% (I40M10), and 35:15% (I35M15). The results showed the addition of mangrove flour with different concentrations significantly affected the sensory properties of color, aroma, texture, appearance and water content and protein content of tuna sticks but did not significantly affect the taste sensory attributes. The sensory attributes of color, aroma, texture, appearance, water content and protein content obtained the highest average values were 7.08, 6.07, 7.03, 6.6, 9.52 respectively and 14.58 while the sensory attributes of taste obtained the highest average values around 6.71. The combination of the use of fish meat and mangrove flour on the color and aroma sensory attributes of the I35M15 treatment is preferred while the sensory attributes of the texture, taste, and appearance of I40M10 are preferred. Keywords: Bruguiera gymnorrhiza, mangroves, sensoric, Thunnus sp., tuna sticks.ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh penambahan tepung mangrove terhadap sifat sensorik dan komposisi kimia stik ikan. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan kombinasi penggunaan daging ikan dan tepung mangrove (dari total bahan stik) berturut-turut:50:0 % (I50M0), 45:5 % (I45M5), 40:10 % (I40M10), dan 35:15 % (I35M15). Hasil penelitian menunjukkan penambahan tepung mangrove dengan konsentrasi yang berbeda berpengaruh nyata terhadap sifat sensorik warna, aroma, tekstur, kenampakan dan kadar air serta kadar protein stik tuna namun tidak berpengaruh nyata pada atribut sensorik rasa. Nilai rerata tertinggi pada atribut sensorik warna, aroma, tekstur, kenampakan, kadar air dan kadar protein berturut-turut yaitu 7.08, 6.07, 7.03, 6.6, 9.52 dan 14.58 sedangkan pada atribut sensorik rasa diperoleh nilai rerata tertinggi sekitar 6,71. Kombinasi penggunaan daging ikan dan tepung mangrove pada atribut sensorik warna dan aroma perlakuan I35M15 lebih disukai sedangkan pada atribut sensorik tekstur, rasa dan kenampakan I40M10 lebih disukai dibandingkan pada perlakuan I35M15.Kata kunci: Bruguiera gymnorrhiz, mangrove, sensorik, stik tuna, Thunnus sp.
Cross-Talk of Focal Adhesion-Related Gene Defines Prognosis and the Immune Microenvironment in Gastric Cancer
Authors: Mao Deli , Xu Rui , Chen Hengxing , Chen Xiancong , Li Dongsheng , Song Shenglei , He Yulong , Wei Zhewei , Zhang Changhua 
Published: October 2021

Background: Focal adhesion, as the intermediary between tumor cells and extracellular matrix communication, plays a variety of roles in tumor invasion, migration, and drug resistance. However, the potential role of focal adhesion-related genes in the microenvironment, immune cell infiltration, and drug sensitivity of gastric cancer (GC) has not yet been revealed.Methods: The genetic and transcriptional perspectives of focal adhesion-related genes were systematically analyzed. From a genetic perspective, the focal adhesion index (FAI) was constructed based on 18 prognosis-related focus adhesion-related genes to evaluate the immune microenvironment and drug sensitivity. Then three prognosis-related genes were used for consistent clustering to identify GC subtypes. Finally, use FLT1, EGF, COL5A2, and M2 macrophages to develop risk signatures, and establish a nomogram together with clinicopathological characteristics.Results: Mutations in the focal adhesion-related gene affect the survival time and clinical characteristics of GC patients. FAI has been associated with a shorter survival time, immune signaling pathways, M2 macrophage infiltration, epithelial-mesenchymal transition (EMT) signaling, and diffuse type of GC. FAI recognizes ALK, cell cycle, and BMX signaling pathways inhibitors as sensitive agents for the treatment of GC. FLT1, EGF, and COL5A2 may distinguish GC subtypes. The established risk signature is of great significance to the prognostic evaluation of GC based on FLT1, EGF, and COL5A2 and M2 macrophage expression.Conclusion: The focal adhesion-related gene is a potential biomarker for the evaluation of the immune microenvironment and prognosis. This work emphasizes the potential impact of the focal adhesion pathway in GC therapy and highlights its guiding role in prognostic evaluation.
Tunable Schottky Barrier and Interfacial Electronic Properties in Graphene/ZnSe Heterostructures
Authors: Xiao Wenjun , Liu Tianyun , Zhang Yuefei , Zhong Zhen , Zhang Xinwei , Luo Zijiang , Lv Bing , Zhou Xun , Zhang Zhaocai , Liu Xuefei 
Published: October 2021

With a direct bandgap, two-dimensional (2D) ZnSe is a promising semiconductor material in photoelectric device fields. In this work, based on first-principles methods, we theoretically studied the modulation of the Schottky barrier height (SBH) by applying horizontal and vertical strains on graphene/ZnSe heterojunction. The results show that the inherent electronic properties of graphene and ZnSe monolayers are both well-conserved because of the weak van der Waals (vdW) forces between two sublayers. Under horizontal strain condition, the n(p)-type SBH decreases from 0.56 (1.62) eV to 0.21 (0.78) eV. By changing the interlayer distance in the range of 2.8 Å to 4.4 Å, the n(p)-type SBH decreases (increases) from 0.88 (0.98) eV to 0.21 (1.76) eV. These findings prove the SBH of the heterojunction to be tuned effectively, which is of great significance to optoelectronic devices, especially in graphene/ZnSe-based nano-electronic and optoelectronic devices.
Endothelial Function and Arterial Stiffness Should Be Measured to Comprehensively Assess Obstructive Sleep Apnea in Clinical Practice
Authors: Luo Jinmei , Wang Xiaona , Guo Zijian , Xiao Yi , Cao Wenhao , Zhang Li , Su Linfan , Guo Junwei , Huang Rong 
Published: October 2021

Objective: An effective clinical tool to assess endothelial function and arterial stiffness in patients with obstructive sleep apnea (OSA) is lacking. This study evaluated the clinical significance of subclinical markers for OSA management in males without serious complications.Patients/Methods: Males without serious complications were consecutively recruited. Clinical data, biomarker tests, reactive hyperemia index (RHI), and augmentation index at 75 beats/min (AIx75) measured by peripheral arterial tonometry were collected. An apnea hypopnea index (AHI) cutoff of ≥15 events/h divided the patients into two groups.Results: Of the 75 subjects, 42 had an AHI ≥15 events/h. Patients with an AHI ≥15 events/h had higher high-sensitivity C-reactive protein, tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor, and AIx75 values than the control group but no statistical difference in RHI was observed. After controlling for confounders, TNF-α was negatively correlated with the average oxygen saturation (r = −0.258, P = 0.043). RHI was correlated with the rapid eye movement (REM) stage percentage (r = 0.306, P = 0.016) but not with AHI (P &gt; 0.05). AIx75 was positively correlated with the arousal index (r = 0.289, P = 0.023) but not with AHI (r = 0.248, P = 0.052).Conclusions: In males with OSA without severe complications, TNF-α and AIx75 are independently related to OSA. The role of RHI in OSA management requires further elucidation. These markers combined can comprehensively evaluate OSA patients to provide more evidence for the primary prevention of coronary heart disease and treatment response assessment.
Locating Organizations and Their Methods in Registrations of Clinical Migraine Trials: Analysis of ClinicalTrials.gov
Authors: Zhang Pengfei , Do Thien Phu 
Published: October 2021

Background and Objective:ClinicalTrials.gov is a centralized venue for monitoring clinical research and allows access to information on publicly and privately funded studies. To better recognize influential institutions in the field of headache, we identified major organizations conducting clinical trials in migraine research. Furthermore, we examined the frequency of different study designs.Methods: Utilizing the ClinicalTrials.gov application programming interface, we extracted studies including individuals with migraine from February 29, 2000, to July 28, 2020, for the following: (1) host organization, (2) study type, (3) primary purpose, (4) intervention model, and (5) allocation.Results: We included 921 entries encompassing 423 organizations. Thirty-two organizations produced ≥5 entries each and 40.0% of all entries. Most, 86%, were interventional studies while 13.6% were observational studies. The most common study design had a randomized allocation of participants. The most frequent primary purpose was treatment (62.4%) followed by prevention (13.0%). There were 56.9% parallel assignment models, 15.2% single group assignment models, and 12.4% crossover assignment models.Conclusion: A minority of organizations contribute to a significant number of registrations of clinical migraine trials, suggesting that clinical research in migraine is oligarchic. The most common study is interventional and randomized, with parallel assignment of participants with treatment as the primary purpose. This likely reflects the need to evaluate novel putative pharmacological medications.
Biliary Rhabdomyosarcoma in Pediatric Patients: A Systematic Review and Meta-Analysis of Individual Patient Data
Authors: Fuchs Juri , Murtha-Lemekhova Anastasia , Kessler Markus , Günther Patrick , Fichtner Alexander , Pfeiffenberger Jan , Probst Pascal , Hoffmann Katrin 
Published: October 2021

BackgroundThe biliary tree is a rare location of pediatric rhabdomyosarcoma. Due to the low incidence, there is a lack of evidence concerning therapeutic guidelines for this tumor location. In particular, the impact of surgery is discussed controversially.PurposeObjective is to generate evidence-based treatment guidelines for pediatric biliary rhabdomyosarcoma (BRMS). All available published data on therapeutic regimens and important prognostic factors are investigated with a focus on the role of surgery.MethodsA systematic literature search of MEDLINE, Web of Science, and CENTRAL was performed. Patient data were entered individually. Data was pooled and qualitative and quantitative analyses of demographic data, therapy, postoperative/interventional outcomes, relapse, and survival were conducted. In an individual patient data analysis, cox regression was applied to identify key factors predicting the outcome of patients with BRMS.Results65 studies met the inclusion criteria, providing data on 176 patients with BRMS. Individual patient data analysis showed a 5-year overall survival and progression-free survival of 51% and 50% for the total study population. For patients treated after 2000, 5-year OS and PFS was 65% and 59%, respectively. Absence of surgical tumor resection was an independent risk factor for death (Hazard ratio 8.9, 95%-CI 1.8-43.6, p = 0.007) and significantly associated with recurrent disease and disease-related death.ConclusionThis analysis provides comprehensive information on the largest number of patients hitherto reported in the literature. BRMS is still associated with high morbidity and mortality. Surgical tumor resection is essential for appropriate oncological treatment of BRMS. International cooperation studies are needed to enhance evidence and improve the outcome of this orphan disease.Protocol RegistrationPROSPERO (CRD42021228911) https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021228911.
Suppression of Dendritic Cell Maturation by Kefir Peptides Alleviates Collagen-Induced Arthritis in Mice
Authors: Chen Chien-Fu , Li Hsin-Pei , Chao Ya-Hsuan , Tu Min-Yu , Yen Chih-Ching , Lan Ying-Wei , Yang Shang-Hsun , Chong Kowit-Yu , Lin Chi‐Chien , Chen Chuan-Mu 
Published: October 2021

Arthritis is a disorder that is characterized by joint inflammation and other symptoms. Rheumatoid arthritis (RA), an autoimmune disease, is one of the most common arthritis in worldwide. Inflammation of the synovium is the main factor that triggers bone erosion in the joints in RA, but the pathogenesis of RA is not clearly understood. Kefir grain-fermented products have been demonstrated to enhance immune function and exhibit immune-modulating bioactivities. This study aims to explore the role of kefir peptides (KPs) on the regulation of dendritic cell, which are found in RA synovial fluid, and the protection effects of KPs on mice with collagen-induced arthritis (CIA). Immature mouse bone marrow-derived dendritic cells (BMDCs) were treated with KPs (2.2 and 4.4 mg/ml) and then exposed to lipopolysaccharide (LPS) to study the immune regulation function of KPs in dendritic cells. Mice with CIA (n = 5 per group) were orally administrated KPs (3.75 and 7.5 mg/day/kg) for 21 days and therapeutic effect of KPs on mice with arthritis were assessed. In this study, we found that KPs could inhibit surface molecule expression, reduce inflammatory cytokine release, and repress NF-κB and MAPK signaling in LPS-stimulated mouse BMDCs. In addition, a high dose of KPs (7.5 mg/kg) significantly alleviated arthritis symptoms, decreased inflammatory cytokine expression, suppressed splenic DC maturation and decrease the percentage of Th1 and Th17 in the spleens on mice with CIA. Our findings demonstrated that KPs ameliorate CIA in mice through the mechanism of suppressing DC maturation and inflammatory cytokine releases.
The Effects of Aerobic Exercise on Oxidative Stress in Older Adults: A Systematic Review and Meta-Analysis
Authors: Ye Yu , Lin Huiying , Wan Mingyue , Qiu Pingting , Xia Rui , He Jianquan , Tao Jing , Chen Lidian , Zheng Guohua 
Published: October 2021

Background: Oxidative stress (OS) plays an important role in the progression of many aging-related diseases. Exercises can delay this kind of progress, but aerobic exercise is the most commonly used type of training among older adults; therefore, its influence needs to be further verified.Methods: A literature search was conducted in eight electronic databases, including Cochrane, EMBASE, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang Date, and SinoMed from their inception to April 2020. Methodological quality was assessed using Cochrane RoB tool v2.0 for individual studies, and RevMan 5.3 software was used to perform the meta-analysis.Results: The meta-analysis included 20 studies, involving 1,170 older adults. The results showed that regular aerobic exercise could reduce blood oxidant markers, including malondialdehyde (MDA; SMD=−1.80, 95% CI −2.46 to −1.14, p&lt;0.001) and lipid peroxide (LPO; SMD=−1.12, 95% CI −2.03 to −0.22, p=0.02), and increase the levels of antioxidant factors, such as nitric oxide (NO; SMD=0.89, 95% CI 0.37–1.41, p&lt;0.001), superoxide dismutase (SOD; SMD=0.63, 95% CI 0.25–1.01, p=0.001), and total antioxidant capacity (TAC; SMD=1.22, 95% CI 0.45–1.98, p=0.002), with clear statistical significance. It may also improve the levels of other OS markers, such as 8-OHdG, 8-isoPGF2, VE, and reduced glutathione/oxidized glutathione (GSH/GSSG).Conclusion: Regular aerobic exercise may have a positive effect on the OS levels of older adults by reducing some oxidant markers and increasing antioxidant marker levels.
Effect of Essential Oils on the Inhibition of Biofilm and Quorum Sensing in Salmonella enteritidis 13076 and Salmonella typhimurium 14028
Authors: Guillín Yuliany , Cáceres Marlon , Torres Rodrigo , Stashenko Elena , Ortiz Claudia 
Published: October 2021

The emergence of multidrug-resistant microorganisms represents a global challenge that has led to a search for new antimicrobial compounds. Essential oils (EOs) from medicinal aromatic plants are a potential alternative for conventional antibiotics. In this study, the antimicrobial and anti-biofilm potential of 15 EOs was evaluated on planktonic and biofilm-associated cells of Salmonella enterica serovar Enteritidis ATCC 13076 (S. enteritidis) and Salmonella enterica serovar Typhimurium ATCC 14028 (S. typhimurium). In total, 4 out of 15 EOs showed antimicrobial activity and 6 EOs showed anti-biofilm activity against both strains. The EO from the Lippia origanoides chemotype thymol-carvacrol II (LTC II) presented the lowest minimum inhibitory concentration (MIC50 = 0.37 mg mL−1) and minimum bactericidal concentration (MBC = 0.75 mg mL−1) values. This EO also presented the highest percentage of biofilm inhibition (>65%) on both microorganisms, which could be confirmed by scanning electron microscopy (SEM) images. Transcriptional analysis showed significant changes in the expression of the genes related to quorum sensing and the formation of the biofilm. EOs could inhibit the expression of genes involved in the quorum sensing mechanism (luxR, luxS, qseB, sdiA) and biofilm formation (csgA, csgB, csgD, flhD, fliZ, and motB), indicating their potential use as anti-biofilm antimicrobial agents. However, further studies are needed to elucidate the action mechanisms of essential oils on the bacterial cells under study.
On violation of the logic of the legal mechanism of bringing to justice for beatings and additional measures for their prevention
Authors: Drozd Aleksey , Ravnyushkin Aleksandr 
Published: October 2021

The relevance of the research is determined by a legal gap in the current legislation, which lies in the fact that when bringing a person who has committed a crime under Article 116.1 of the Criminal Code of the Russian Federation repeatedly in relation to the same person to responsibility, the state of the criminal record of this criminal is not taken into account.
In this case, a person who has unexpunged or outstanding convictions, when committing battery for the third time, according to common sense, should be brought to criminal responsibility, and not to administrative responsibility, as is currently the case.
In order to eliminate this conflict, the authors propose to include part 2 of Art. 1161 of the Criminal Code of the Russian Federation, which provides for the liability of a person who has an unexpunged or outstanding conviction in relation to the same person. At the same time, the authors consider it necessary to include a group of criminal cases considered as cases of public prosecution to part 2 of Art. 1161 of the Criminal Code of the Russian Federation.
The authors also see an urgent problem of the need to improve the effectiveness of the prevention of domestic violence through the inclusion of new legal means in legislation and law enforcement practice. Attempts to implement the norms of international acts providing for legal means of preventing domestic violence in the Russian Federation, as well as the study of foreign experience on this issue, according to the authors, looks ambiguous and is debatable. In particular, the issue of introducing protective orders and orders as administrative and legal means of preventing administrative offenses through the adoption of the federal law «On the Prevention of Domestic Violence in the Russian Federation» is being considered.
According to the authors, taking into account the foreign practice, there are sufficient grounds to believe that protective prescriptions and some other means will not be able to confirm their effectiveness in Russia.
Legal and pedagogical directions for the development of management education in the internal affairs bodies of the Russian Federation under conditions of digitalization
Authors: Vahnina Viktoriya , Serdyuk Natal'ya 
Published: October 2021

The prerequisites for the study is an increase in the number of new types of crime, including those committed with the use of digital technologies, which requires new methodological and methodical approaches to the training of personnel for the internal affairs bodies of the Russian Federation and, above all, their vanguard - executives at all levels.
The purpose of the study is to identify the main directions for the development of management education in the system of law enforcement bodies of the Russian Federation, to substantiate the need for the development and approbation of innovative teaching methods in the context of digitalization.
Research method: questioning, survey, participant observation, expert assessments, summative and formative assessment.
The most important results of the study in which full-time and part-time students of the Faculty of Management took part during 2019-2020 (N-1273) made it possible to define, substantiate and check the effectiveness of the following directions for the development of managerial education in the internal affairs bodies of the Russian Federation in the context of digitalization: the formation and development of digital competence of executives; case-based learning in situational management of internal affairs bodies; creation and implementation of individual educational training routes; the use of distance learning technologies, including the final certifying examination in online study mode; implementation of quasiprofessional activities of students in the player space of polygons, situational centers, center of commandstaff exercises; development of professionally significant personal qualities of executives, training in tactics and methods of personal professional safety, prevention of professional deformation and anti-corruption standard of behavior; accumulation of electronic components of information and educational environments of educational institutions.
State policy on personnel training in educational organizations of the Ministry of Interior of Russia: trends and prospects
Authors: Igoshin Nikolay , Marchenko Gennadiy , Chimarov Sergey 
Published: October 2021

The implementation of an unified educational policy is carried out on the basis of the realization of the main provisions of the state personnel policy. Therefore, their general (initial) principles are statutory in federal legislation, and departmental features taking into account sectoral interests are regulated by departmental documents.
The analysis of legal norms carried out by the authors shows that at present the goals, objectives and other conceptual foundations of state policy in the field of education and science are contained not only in the provisions of the Constitution of the Russian Federation, the Federal Law «Education Act in the Russian Federation», Federal State Educational Standards, but also in other legal acts regulating the activities of subjects of educational policy.
The state educational policy, first of all, proceeds from the priority of the rights, freedoms and interests of man and citizen enshrined in the Constitution of the Russian Federation. In accordance with the provisions of the country’s fundamental law, the right to education is recognized as one of the fundamental and inalienable constitutional rights of a Russian citizen.
The success of the realization of the state policy on personnel training in educational institutions of the Ministry of Interior of Russia, according to the authors of the article, directly depends on the compliance of the system of scientific and methodological support of the educational process with its goals.
As part of the publication submitted for consideration to the scientific community, it is proposed to get acquainted with the results of scientific research related to the determination of the directions of scientific and methodological support for the education and training of police officers in educational organizations of the system of the Ministry of Interior of the Russian Federation.