bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baseline QRS Duration Associates with Cardiac Recovery in Patients with Continuous-Flow Left Ventricular Assist Device Implantation
Authors: Khan Muhammad S. , Kyriakopoulos Christos P. , Taleb Iosif , Dranow Elizabeth , Scott Monte , Ranjan Ravi , Yin Michael , Tseliou Eleni , Alharethi Rami , Caine William , Shaw Robin M. , Selzman Craig H. , Drakos Stavros G. , Dosdall Derek J. 
Published: September 2021

BACKGROUNDIn chronic heart failure (HF) patients supported with continuous-flow left ventricular assist device (CF-LVAD), we aimed to assess the clinical association of baseline QRS duration (QRSd) with post-LVAD cardiac recovery, and its correlation with pre- to post-LVAD change in left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVEDD).METHODSChronic HF patients (n=402) undergoing CF-LVAD implantation were prospectively enrolled, at one of the centers comprising the U.T.A.H. (Utah Transplant Affiliated Hospitals) consortium. After excluding patients with acute HF etiologies, hypertrophic or infiltrative cardiomyopathy, and/or inadequate post-LVAD follow up (<3 months), 315 patients were included in the study. Cardiac recovery was defined as LVEF ≥40% and LVEDD <6 cm within 12 months post-LVAD implantation. Patients fulfilling this condition were termed as responders (R) and results were compared with non-responders (NR).RESULTSThirty-five patients (11%) achieved ‘R’ criteria, and exhibited a 15% shorter QRSd compared to ‘NR’ (123±37 ms vs 145±36 ms; p<0.001). A univariate analysis identified association of baseline QRSd with post-LVAD cardiac recovery (OR:0.986, 95% CI:0.976-0.996, p<0.001). In a multivariate logistic regression model, after adjusting for duration of HF (OR:0.990, 95% CI:0.983-0.997, p=0.006) and gender (OR:0.388, 95% CI:0.160-0.943, p=0.037), pre-LVAD QRSd exhibited a significant association with post-LVAD cardiac structural and functional improvement (OR:0.987, 95% CI:0.977-0.998, p=0.027) and the predictive model showed a c-statistic of 0.73 with p<0.001. The correlations for baseline QRSd with pre- to post-LVAD change in LVEF and LVEDD were also investigated in ‘R’ and ‘NR’ groups.CONCLUSIONChronic advanced HF patients with a shorter baseline QRSd exhibit an increased potential for cardiac recovery after LVAD support.
Laboratory and field evaluation of the STANDARD Q and Panbio™ SARS-CoV-2 antigen rapid test in Namibia using nasopharyngeal samples
Authors: Konstantinus Iyaloo , Chiwara Douglas , Ndevaetela Emmy-Else , Ndarukwa-Phiri Victoria , !Garus-oas Nathalia , Frans Ndahafa , Ndumbu Pentikainen , Shiningavamwe Andreas , van Rooyen Gerhard , Schiceya Ferlin , Hlahla Lindile , Namundjebo Pendapala , Ndozi-Okia Ifeoma , Chikuse Francis , Bantiewalu Sirak Hailu , Tjombonde Kapena 
Published: September 2021

AbstractBackgroundAs new SARS-CoV-2 variants of concern emerge, there is a need to scale up testing to minimize transmission of the Coronavirus disease 2019 (COVID-19). Many countries especially those in the developing world continue to struggle with scaling up reverse transcriptase polymerase reaction (RT-PCR) to detect SARS-CoV-2 due to scarcity of resources. Alternatives such as antigen rapid diagnostics tests (Ag-RDTs) may provide a solution to enable countries to scale up testing.MethodsIn this study, we evaluated the Panbio™ and STANDARD Q Ag-RDTs in the laboratory using 80 COVID-19 RT-PCR confirmed and 80 negative nasopharyngeal swabs. The STANDARD-Q was further evaluated in the field on 112 symptomatic and 61 asymptomatic participants.ResultsFor the laboratory evaluation, both tests had a sensitivity above 80% (Panbio™ = 86% vs STANDARD Q = 88%). The specificity of the Panbio™ was 100%, while that of the STANDARD Q was 99%. When evaluated in the field, the STANDARD Q maintained a high specificity of 99%, however the sensitivity was reduced to 56%.ConclusionUsing Ag-RDTs in low resource settings will be helpful, however, negative results should be confirmed by RT-PCR where possible to rule out COVID-19 infection.
Demographic Analysis of Mutations in Indian SARS-CoV-2 Isolates
Authors: Agarwal Kushagra , Parekh Nita 
Published: September 2021

AbstractIn this study we carried out the early distribution of clades and subclades state-wise based on shared mutations in Indian SARS-CoV-2 isolates collected (27th Jan – 27th May 2020). Phylogenetic analysis of these isolates indicates multiple independent sources of introduction of the virus in the country, while principal component analysis revealed some state-specific clusters. It is observed that clade 20A defining mutations C241T (ORF1ab: 5’ UTR), C3037T (ORF1ab: F924F), C14408T (ORF1ab: P4715L), and A23403G (S: D614G) are predominant in Indian isolates during this period. Higher number of coronavirus cases were observed in certain states, viz., Delhi, Tamil Nadu, and Telangana. Genetic analysis of isolates from these states revealed a cluster with shared mutations, C6312A (ORF1ab: T2016K), C13730T (ORF1ab: A4489V), C23929T, and C28311T (N: P13L). Analysis of region-specific shared mutations carried out to understand the large number of deaths in Gujarat and Maharashtra identified shared mutations defining subclade, I/GJ-20A (C18877T, C22444T, G25563T (ORF3a: H57Q), C26735T, C28854T (N: S194L), C2836T) in Gujarat and two sets of co-occurring mutations C313T, C5700A (ORF1ab: A1812D) and A29827T, G29830T in Maharashtra. From the genetic analysis of mutation spectra of Indian isolates, the insights gained in its transmission, geographic distribution, containment, and impact are discussed.
NOVEL MANAGEMENT OF DEPRESSION USING KETAMINE IN THE INTENSIVE CARE UNIT
Authors: Kaur Nirmaljot , Yarrarapu Siva Naga S. , Giri Abhishek R. , Rottman Pietrzak Kathleen A. , Santos Christan , Lowman Philip E. , Niaz Shehzad , Franco Pablo Moreno , Sanghavi Devang K. 
Published: September 2021

AbstractBackgroundKetamine, a dissociative anesthetic, induces remission of depression by antagonizing glutaminergic NMDA receptors. Ketamine has been used previously in outpatient setting for treatment-resistant depression, but we showcase its utility in depression management at the Intensive Care Unit (ICU).Research QuestionCan ketamine be used for depression treatment in ICU patients?Study Design and MethodsA retrospective chart review of ICU patients was done at a tertiary center from 2018 to 2021, to assess the ketamine usage. Among the patients reviewed, ketamine was used for depression in 12, and for analgesia & sedation in 2322 patients. Ketamine was administered in doses of 0.5mg/kg & 0.75mg/kg for depression. Each course consisted of 3 doses of ketamine administered over 3 days. 7 in 12 patients received a single course of ketamine. The rest received 3-4 courses 1 week apart.ResultsKetamine was found to improve mood and affect in most of the patients with depression. 11 in 12 patients had a positive response with better sleep. It has a major advantage over conventional anti-depressants since it takes only a few hours to induce remission. Patients who refused to eat and follow treatment protocol, and who would otherwise succumb to death if not for the rapid remission of depression, were administered ketamine.ConclusionA major drawback of ketamine is that the duration of remission is short, with the response lasting only up to 7 days after a single dose. Hence, all the patients in our study were weaned off ketamine with a supporting antidepressant. Ketamine has been documented to cause cardio-neurotoxicity; however, only one patient had worsening lethargy in our study. To conclude, ketamine has a monumental benefit in treating depression in the ICU. Although our study was associated with positive outcomes, there is a need for prospective studies with long-term follow-up assessments.
Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells
Authors: Brunsdon Hannah , Brombin Alessandro , Peterson Samuel , Postlethwait John H. , Patton E. Elizabeth 
Published: September 2021

ABSTRACTMelanocyte stem cells (McSCs) in zebrafish serve as an on-demand source of melanocytes during growth and regeneration, but metabolic programs associated with their activation and regenerative processes are not well known. Here, using live imaging coupled with scRNA-sequencing, we discovered that quiescent McSCs during regeneration activate a dormant embryonic neural crest transcriptional program followed by an aldehyde dehydrogenase (Aldh) 2 metabolic switch to generate progeny. Unexpectedly, while ALDH2 is well known for its aldehyde clearing mechanisms we find that in regenerating McSCs, Aldh2 activity is required to generate formate – the one-carbon (1C) building block for nucleotide biosynthesis – through formaldehyde metabolism. Consequently, we find that disrupting the 1C cycle with low-doses of methotrexate caused melanocyte regeneration defects. In the absence of Aldh2, we find that purines (but not pyrimidines) are the metabolic end product sufficient for activated McSCs to generate progeny. Together, our work reveals McSCs undergo a two-step cell state transition during regeneration, and that the reaction products of Aldh2 enzymes have tissue-specific stem cell functions that meet metabolic demands in regeneration.SUMMARY STATEMENTIn melanocyte regeneration, quiescent McSCs respond by re-expressing a neural crest identity, followed by an Aldh2-dependent metabolic switch to generate progeny.
An analysis of celebrity repositioning through reality television
Authors: Kabra Shradha , Dass Sumanjit , Popli Sapna 
Published: September 2021

PurposeReality television is a dynamic, profit-making platform that occupies prime-time slots on the television almost all over the world. Despite its immense popularity and influence, it has received little attention in the extant literature and almost none in terms of its impact on celebrity repositioning. This study aims at examining the relationship between the film stars as brands and the impact of the platform of reality television in repositioning these celebrities in the Indian context.Design/methodology/approachThrough extensive literature review and qualitative interviews, the paper expounds that reality television provides an opportunity to celebrities to successfully reposition themselves at crucial junctures in their career. The framework to study this repositioning has been adopted from the work of Chris Simms and Paul Trott (2007) who created it to study the brand repositioning of various consumer goods.FindingsThe literature establishes celebrities as brands. This study provides evidence that brand repositioning through reality television is possible for these celebrity brands. The symbolic and functional repositioning of these celebrities is presented through thematic content analysis.Research limitations/implicationsThe study provides a useful framework to understand celebrity brand repositioning through reality TV. It can also be replicated to understand the repositioning of a wide variety of celebrities other than film-stars such as sportspersons, social media influencers and politicians.Originality/valueThe paper contributes to the need of expanding the corpus of Indian reality television and explains how Indian celebrities reposition themselves through reality television.
Construction over operation? A study of the usage of digital humanities databases in China
Authors: Gao Dan , He Lin , Liu Jingru , Li Zhangchao 
Published: September 2021

PurposeDigital humanities database is one of the essential tools in digital humanities research area. Therefore, examining the usage of digital humanities database in academic papers is conducive to assessing the value of digital humanities database for scientific research activities and improving the construction of digital humanities infrastructure.Design/methodology/approachThis paper constructs an evaluation system of digital humanities database from the perspective of academic influence and social influence, with mention frequency, usage motivation, platform access data, usage region and usage discipline as indicators and takes China Biographical Database Project as the empirical object to explore the usage of digital humanities database in China.FindingsThe data analysis result demonstrates that digital humanities databases are widely used and recognized in China. However, the problem of low actual usage remains.Originality/valueThis paper constructs the digital humanistic database's evaluation system and discusses applying the digital humanistic database in China, which provides a new perspective and method for the influence evaluation study of the digital humanistic database.
Effects of globalization on food production in five European countries
Authors: Khatami Fahimeh , Ricciardi Francesca , Cavallo Angelo , Cantino Valter 
Published: September 2021

PurposeThe purpose of this paper is to investigate the effects of globalization convergence (GC) and its components (social, economic, political, technological and ecological) on food production (FP).Design/methodology/approachThe methodological approach adopted is based on a quantitative approach, using a static panel data analysis with relevant data from five European countries within five time intervals (2013–2017).FindingsThe results indicated that three components of globalization (social, technological and ecological) could significantly contribute to the food industry, while two other components of globalization (economic and political) are negatively correlated with FP.Research limitations/implicationsThis study contributes to the theoretical recognition of the role of globalization in influencing FP in multidisciplinary interactions. Meanwhile, this study's main limitation lies in the statistical method of panel data analysis, since temporal and spatial changes have not been investigated.Originality/valueDespite the literature on globalization's effect on FP, each globalization component's effect has not been investigated appropriately within cross-countries studies. Hence, the present study addresses a gap in the extant literature by examining the globalization effects on the food industry to promote globalized food security, opportunities and solutions in the study areas.
When pursuing more career, success hits home and job: examining the cost of vocational delay of gratification
Authors: Liu Xiaoyan , Yu Kun 
Published: September 2021

PurposeThe purpose of the paper is to understand the detrimental effects of vocational delay of gratification (VDG) based on the ego-depletion perspective and to explore the specific mechanism in this dynamic process.Design/methodology/approachThe study used experience sampling to survey 89 employees at 3 time points within each day over 10 days and built a 4-stage sequential mediation model.FindingsResults revealed that, at the daily level, afternoon VDG had a positive effect on end-of-day work–family conflict through afternoon ego depletion. The work–family conflict continued the state of ego depletion to the next morning and led to poor job dedication the next morning.Research limitations/implicationsThe findings suggest organizations and employees should consider not only the benefits of delay of gratification (DG) but the costs as well.Originality/valueThe current study is the first to investigate a dark side of VDG and to explore its underlying mechanism.
Hydrothermal characteristics of a double flow parabolic trough solar collector equipped with sinusoidal-wavy grooved absorber tube and twisted tape insert
Authors: Abbasian Arani Ali Akbar , Memarzadeh Ali 
Published: September 2021

Purpose
Present investigation conducts a study on the hydrothermal features of a double flow Parabolic Trough Solar Collector (PTSC) equipped with sinusoidal-wavy grooved absorber tube and twisted tape insert filled with nanofluid. This paper aims to present an effectual PTSC which is comprised by nanofluid numerically by means of finite volume method.

Design/methodology/approach
The beneficial results such as pressure drop inside the absorber tube, mean predicted friction factor, predicted average Nusselt number and hydrothermal Performance Evaluation Criteria (PEC) are evaluated and reported to present the influences of numerous factors on studied interest outcomes. Effects of different Reynolds numbers and environmental conditions are also determined in this investigation.

Findings
It is found that using the absorber roof (canopy) can enhance the heat transfer ratio of PTSCs significantly during all studied Reynolds numbers. Also, it is realized that the combination of inner grooved surface, outer corrugated surface and inserting turbulator can improve the thermal-hydraulic characteristics of PTSCs sharply.

Originality/value
Novel PTSC (N.PTSC) filling with two Heat Transfer Fluids (HTFs), inner and outer surface corrugated absorber tube, absorber roof and inserting twisted tape (N.PTSC.f) has the highest PEC values among all novel configurations along all investigated Reynolds numbers which is followed by configurations N.PTSC with two HTFs and inserting twisted tape (N.PTSC.e), N.PTSC with two HTFs and outer surface corrugated absorber tube (N.PTSC.b) and N.PTSC with two HTFs and inner surface corrugated absorber tube (N.PTSC.c), respectively. N.PTSC.f Nusselt number values can overcome the high values of friction factor, and therefore is introduced as the most efficient model in the current study.
Hand measurement and analysis based on image and mark watershed algorithm
Authors: Fan Danyi , Ma Ximing , Wang Lijun 
Published: September 2021

PurposeThe purpose of this paper is to propose a method for hand measurement based on image and marker watershed algorithm, and combine the data to analyze the shape and characteristics of the hand.Design/methodology/approachA portable hand image capturing instrument was designed and manufactured, and the hand images and dimensions of 328 young men in Zhejiang area were obtained. The outer contour curve of the hand and the key points of finger root, fingertip, wrist and knuckle position were extracted. Then, the size of each hand part was calculated. The hand data obtained from the two-dimensional image was compared with the manual measurement data. Finally, the hands were classified according to the measurement data, and the relationship between hand control size and hand length, hand width and the relationship between hand length and height were explored.FindingsThe data comparison results show that the two measurement methods have high data consistency and are replaceable. In addition, analyzing the data obtained four major characteristic factors that affect the shape of the hand, divided the hands of young men in Zhejiang into five categories, and obtained the regression equations of basic hand size, hand length and hand width, and obtained the regression equation of hand length and height.Originality/valueThe method proposed in this study to obtain hand size based on the image and mark watershed algorithm has lower requirements on the external environment and testers, conforms to the development trend of applying artificial intelligence to anthropometric engineering and provides a useful reference value for data collection of gloves specification design. In addition, the results of data analysis can provide a valuable reference basis for consumer hand shape predictions, which can be used to guide the research and production of hand instruments, the design of specifications series and the purchase of hand products.
Digital working during the COVID-19 pandemic: how task–technology fit improves work performance and lessens feelings of loneliness
Authors: Abelsen Simen Nordbø , Vatne Svenn-Helge , Mikalef Patrick , Choudrie Jyoti 
Published: September 2021

PurposeThis study aims to investigate the relationship between information and communication technologies (ICTs) use and work performance during the coronavirus disease 2019 (COVID-19) pandemic. Specifically, it aims to understand what the role of task–technology fit is, and what effect this has on feelings of loneliness of individuals and their subsequent work performance. As a large proportion of workers are required to work from home during the ongoing COVID-19 pandemic, understanding what aspects contribute to higher performance and reduced negative psychological outcomes is of increased practical and research interest.Design/methodology/approachTo explore these questions, a quantitative approach that employed a sample population of 357 individuals who worked from home during the COVID-19 pandemic was used. Using a convenience, purposive and snowball sampling approach the authors collected data through a custom-built online questionnaire, and analyzed the data using structural equation modeling (SEM).FindingsThe results highlight the effect that high task–technology fit has in both directly and indirectly influencing work performance of individuals. The authors find that by designing ICTs based on task–technology fit principles, individuals are less likely to experience feelings of loneliness while working from home and are more prone to perform better in their work-related tasks.Originality/valueThis study offers a new perspective on the role fit of tasks with technology have on influencing psychological states, and indirectly influencing work-related outcomes. The authors, therefore, expand the understanding about why task–technology fit is sought after by explaining part of the psychological mechanisms through which it has an effect on work performance.
Development and characterization of enzymatic biosensor based on lipase from porcine pancreas for propylparaben detection
Authors: Snani Leila , Zougar Saida , Benamia Fatiha , Ghodbane Ilhem 
Published: September 2021

PurposeThe purpose of this paper is to study the immobilization of porcine pancreatic lipase (PPL), in an organic matrix by a covalent cross-linking method to sense propylparaben (PP) present in aqueous solution.Design/methodology/approachPPL immobilization was performed by the covalent cross-linking method, using bovine serum albumin (BSA) in the presence of saturated glutaraldehyde vapor (GA). The preparation of the enzymatic membrane involves the incorporation of porcine pancreatic lipase (PPL), bovine serum albumin (BSA) and glycerol into a phosphate buffer solution (PBS). Characterization of this sensor was performed by impedance spectroscopy (EIS) and scanning electron microscope (SEM). The effect of experimental conditions such as PPL activity, potential, scan rate, PP concentration, pH and presence of interfering elements were studied by cyclic voltammetry.FindingsUnder the optimal experimental conditions, a number of significant factors were optimized. The method exhibited good linearity in the range of 10–14to 10–9 mol/L with a good correlation coefficient of 0.957, detection limit (LOD) of 3.66 × 10–15 mol/L and high sensitivity of 1.086 mA mol−1L. The authors also obtained a very good coverage rate of the surface equal to 91.44%, and hydrolytic activity of lipase is evaluated to 26.64 mmol min−1. The stability and the interference were also evaluated. The equivalent circuit used to explain the electrochemical behavior of modified electrode is a Randle circuit.Practical implicationsThe main application of biosensors is the detection of biomolecules that are either indicators of a disease. For example, electrochemical biosensing techniques can be used as clinical tools to detect breast tumors, because these compounds (PP) were found in breast tumors.Originality/valueThe result registered in this paper indicates that the developed sensor is an efficient, fast, simple and inexpensive analytical tool that can be used for the analysis of water containing PP.