bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Treatment for Patients With Binder Syndrome, Clinical Features and Associated Symptoms: A Systematic Review
Authors: Kerbrat Adeline , Ferri Joel 
Published: October 2021

Background:Binder syndrome is a rare congenital malformation of the midface. Since 1990, no systematic review has been conducted on this condition. Our study aims to review and collect the surgical treatment options available for correcting nasomaxillary dysplasia and the information available in the international literature on Binder syndrome and associated symptoms.Methods:This systematic literature review was registered in the PROSPERO (International Prospective Register of Systematic Reviews) database. Systematic literature searches were performed in Medline, Scopus, the Cochrane Library, and Web of Science databases. Study quality assessment was performed according to recommendations from theCochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy.Results:The authors identified 200 articles from our database research. One hundred sixty-nine articles were excluded after the title and abstract screening. Seven articles were excluded after screening the full text. In total, 24 clinical studies were included: 14 studies aim to describe a surgical option and 10 articles treat information about Binder syndrome or associated features. Most of the studies (12/14 studies) performed rhinoplasties to treat nasomaxillary dysplasia. The 2 other articles evaluated maxillary osteotomy techniques. Only 3 articles compared the results obtained from different surgical techniques.Conclusions:No optimal surgical treatment plan has been developed, even if numerous surgical options are available. Etiology is still uncertain.
Three-Dimensional Printed Customized Surgical Guides for the Precise Correction of Complex Midfacial Post-Traumatic Deformities
Authors: Yang Chengshuai , Zhang Chuxi , Wu Jinyang , Xu XiaoFeng , Zhang Yong , Zhang Shilei 
Published: October 2021

Purpose:
The introduction of intraoperative computed tomography and image-guided navigation have demonstrated some advantages for the correction of midfacial post-traumatic deformities. However, these methods still do not achieve satisfactory results. The authors sought to describe a novel method for the precise correction of complex midfacial post-traumatic deformities using three-dimensional printing customized surgical guides.

Methods:
Ten patients with midfacial post-traumatic deformities admitted between January 15, 2018 and August 20, 2020 were included. To design the surgical guide for each patient, preoperative planning and simulation datasets were used as a virtual template. Each surgical guide comprised three-dimensional printing cutting guides and customized titanium plates to guide the osteotomy and repositioning of the fracture fragments intraoperatively. Reduction and fixation were confirmed by intraoperative navigation. Postoperative deviation chromatography analysis and clinical examination were conducted to evaluate the surgical outcome. All operations were successfully performed.

Results:
The average difference between the virtual plans and postoperative results was less than 1.5 mm. The 3- to 6-month follow-up evaluation demonstrated that symptoms were alleviated, and postoperative function and esthetics improved considerably.

Conclusions:
Three-dimensional-printed customized surgical guides can accurately and effectively transfer the virtual surgical plan to the patient and could be considered an ideal and valuable option for this potentially complicated procedure.
Secondary Surgery in Metopic Craniosynostosis: Outcomes in a Tertiary Care Craniofacial Center in Australia
Authors: Chaisrisawadisuk Sarut , Anderson Peter J. , Moore Mark H. 
Published: October 2021

Abstract
Metopic craniosynostosis is a condition in which the metopic suture is prematurely fused. Trigonocephaly and hypotelorism are the major abnormal findings associated with synostosis. Fronto-orbital advancement with cranial remodelling procedure is the widely practised method for correction of the deformities. Previously, a few studies have shown a low incidence of secondary raised intracranial pressure after the primary surgery. Thus, we reviewed our database to investigate the outcomes of metopic craniosynostosis treatment between 1999 and 2020 in Cleft and Craniofacial South Australia. One hundred twelve patients (77 males and 35 females) with metopic synostosis were operated. The mean age of primary surgery was 11.1 months (range 2.8–131.7 months). Ten patients (9%) who had secondary raised intracranial pressure underwent secondary surgery. Among those, the mean age of primary and secondary surgery were 5.4 and 57.1 months, respectively. Syndromic patients were significantly revealed to have a higher incidence of secondary raised intracranial pressure. There were three patients (2.7%) who had other secondary procedures (hardware removal and aesthetic contouring procedures). This cohort identified a higher incidence of secondary raised intracranial pressure requiring secondary surgery than previous studies. Syndromic patients were significantly related to secondary raised intracranial pressure. The patients who had raised intracranial pressure tended to have primary correction at younger age. Long-term multidisciplinary follow-up is mandatory. The demand for secondary surgery for metalwork complications or cosmetic contouring is uncommon.
Efficacy of Using Perichondrioadipodermal Flap With Combined Techniques in Prominent Ear Correction
Authors: Ciloglu Nesibe Sinem , Cin Baris , Keskin Ekrem 
Published: October 2021

Introduction:
Prominent ear is 1 of the most common congenital deformities of the ear. Incidence is reported as approximately 5%. This deformity can classically be the result of antihelix insufficiency, overprojection of concha or combination of both. Less frequently, folded or overprojectile ear lobule can aggravate the deformity. Surgical techniques can be aimed at concha, antihelix formation, lobule positioning. In our study, postoperative results for the combination of suture otoplasty and perichondrioadipodermal flap techniques in prominent ear surgery is discussed in light of the recent literature.

Methods:
Forty-nine patients that were operated for prominent ear deformity in our clinic between 2010 and 2015 were evaluated. Anatomic structures that cause the anomaly was analyzed by photographing concha-scaphoid angle, antithetical fold absence or presence, position of the ear lobule, conchal depth, size of the auricula, and positioning Frankfort Plane parallel to the ground. The patients were photographed preoperatively, at postoperative first week and postoperative sixth month, respectively. Comparison of age, surgical technique, surgical complications, necessity for revision surgery, additional procedures, follow up time, preoperative, and postoperative helix-mastoid bone distance were evaluated.

Results:
Forty-nine patients have been evaluated. Thirty-one of these patients were female, whereas 18 were male. Age of these patients ranged between 6 and 37. Operations were performed in 47 right side ears, and 44 left side ears (97% bilateral and 7% unilateral otoplasty). Preoperative helix-mastoid bone distance ranged between 21 and 33 mm (mean 26.77), whereas postoperative helix-mastoid bone distance was measured between 12 and 22 mm (mean 16.26). Compared to the preoperative values, helix-mastoid distance difference was statistically significant (P < 0.05).

Conclusions:
Asymmetry and recurrence are the most common late complications of prominent ear surgeries. Perichondrioadipodermal flap can be safely added to the combined surgical techniques protecting the cartilage support, therefore, reducing complication rates, with satisfying results.
Jumping Extracorporeal Free Latissimus Dorsi Myocutaneous Flap for Aesthetic Reconstruction After Anterior Skull Base and Orbital Cancer Resection
Authors: Tashiro Kensuke , Hashimoto Kohei , Lee Haesu 
Published: October 2021

Abstract:
The authors introduce successful free latissimus dorsi myocutaneous flap transfer, which was temporarily placed onto the face extracorporeally because the position of orbital defect is far from the submandibular microvascular anastomosis region. The authors then secondarily resected the excess part of the flap after 3 weeks of neovascularization period. Although multistage surgery is needed, jumping extracorporeal flap is a useful option to achieve aesthetic outcomes especially in a challenging situation.
Predictors of quality of life among Brazilian medical students during second coronavirus wave
Authors: Barreto Filipe Silva , Andrade Feitosa Ankilma do Nascimento , de Carvalho Baldaçara Raquel Prudente , Baldaçara Leonardo , de Assis Elisangela Vilar , Ferreira Silva José Bruno Nunes 
Published: October 2021

AbstractObjectiveTo assess the impact of COVID-19 second wave on quality of life (QoL) of Brazilian medical students.MethodsThe data from 210 medical students were collected through a web-based survey between February and March 2021. We assessed information about sociodemographic characteristics, health conditions, electronics tools-related to physical activity (PA-eTool), and health-associated QoL. Multiple linear regression was performed to identify the potential QoL predictors.ResultsThe psychological domain was the most affected, showing lower score during COVID-19 second wave. Being male was a positive predictor in the physical health domain. Spending too much time indoors and sexual minority-group membership were associated with lower perception on psychological well-being. Personal benefit from having PA-eTool accessed and higher income were positively associated with psychological and environmental domains, respectively, and in the overall QoL.ConclusionsPsychological well-being impairment is a long-term negative impact among Brazilian medical students during COVID-19. By evidencing that students’ QoL has been worsened in this global crisis, supportive interventions provided by community and universities are required to aid those vulnerable students facing mental health or QoL impairment.
White matter microstructural integrity across the adult lifespan: Combined perspective of diffusion tensor and kurtosis imaging
Authors: Taha Hiba , Chad Jordan A. , Chen J. Jean 
Published: October 2021

AbstractStudies of healthy brain aging have reported diffusivity patterns associated with white matter degeneration using diffusion tensor imaging (DTI), which assumes that diffusion measured at the typical b-value (approximately 1000 s/mm2) is Gaussian. Diffusion kurtosis imaging (DKI) is an extension of DTI that measures non-Gaussian diffusion (kurtosis) to better capture microenvironmental changes by incorporating additional data at a higher b-value. In this study, using UK Biobank data (b values of 1000 and 2000 s/mm2), we investigate (1) the extent of novel information gained from adding diffusional kurtosis to diffusivity observations in aging, and (2) how conventional DTI metrics in aging compare with diffusivity metrics derived from DKI, which are corrected for kurtosis. We find a general pattern of lower kurtosis alongside higher diffusivity among older adults. We also find differences between diffusivity metrics derived from DTI and DKI, emphasizing the importance of accounting for non-Gaussian diffusion. This work highlights the utility of measuring diffusional kurtosis as a simple addition to conventional diffusion imaging of aging.
In-depth immunophenotyping with mass cytometry during TB treatment reveals non-canonical T-cell subsets associated with sputum culture conversion
Authors: Chedid Carole , Andrieu Thibault , Kokhreidze Eka , Tukvadze Nestani , Biswas Samanta , Ather Md. Fahim , Uddin Mohammad Khaja Mafij , Banu Sayera , De Maio Flavio , Delogu Giovanni , Endtz Hubert , Goletti Delia , Vocanson Marc , Dumitrescu Oana , Hoffmann Jonathan , Ader Florence 
Published: October 2021

AbstractTuberculosis (TB) is a difficult-to-treat infection because of multidrug regimen requirements based on drug susceptibility profiles and treatment observance issues. TB cure is defined by mycobacterial sterilization, technically complex to systematically assess. We hypothesized that microbiological outcome was associated with stage-specific immune changes in peripheral whole blood during TB treatment. The T-cell phenotypes of treated TB patients were prospectively characterized in a blinded fashion using mass cytometry after Mycobacterium tuberculosis (Mtb) antigen stimulation, and then correlated to sputum culture status. At two months of treatment, cytotoxic and terminally differentiated CD8+ T-cells were under-represented and naïve CD4+ T-cells were over-represented in positive-versus negative-sputum culture patients, regardless of Mtb drug susceptibility. At treatment completion, an antigen-driven T-cell immune shift towards differentiated subpopulations was associated with TB cure. Overall, we identified specific T-cell profiles associated with slow sputum converters, which brings new insights in TB prognostic biomarker research designed for clinical application.SummaryIn patients treated for pulmonary TB, high-dimensional immune profiling with mass cytometry revealed that Mycobacterium tuberculosis culture conversion is associated with newly characterized peripheral CD8+ T-cell phenotypes. This paves the way for new immune biomarkers associated with mycobacterial sterilization.
Differential patterns of change in brain connectivity resulting from severe traumatic brain injury
Authors: Nakuci Johan , McGuire Matthew , Schweser Ferdinand , Poulsen David , Muldoon Sarah F. 
Published: October 2021

AbstractBackgroundTraumatic brain injury (TBI) damages white matter tracts, disrupting brain network structure and communication. There exists a wide heterogeneity in the pattern of structural damage associated with injury, as well as a large heterogeneity in behavioral outcomes. However, little is known about the relationship between changes in network connectivity and clinical outcomes.MethodsWe utilize the rat lateral fluid-percussion injury (FPI) model of severe TBI to study differences in brain connectivity in 8 animals that received the insult and 11 animals that received only a craniectomy. Diffusion Tensor Imaging (DTI) is performed 5 weeks after the injury and network theory is used to investigate changes in white matter connectivity.ResultsWe find that 1) global network measures are not able to distinguish between healthy and injured animals; 2) injury induced alterations predominantly exist in a subset of connections (subnetworks) distributed throughout the brain; and 3) injured animals can be divided into subgroups based on changes in network motifs – measures of local structural connectivity. Additionally, alterations in predicted functional connectivity indicate that the subgroups have different propensities to synchronize brain activity, which could relate to the heterogeneity of clinical outcomes.DiscussionThese results suggest that network measures can be used to quantify progressive changes in brain connectivity due to injury and differentiate among subpopulations with similar injuries but different pathological trajectories.Impact StatementWhite matter tracts are important for efficient communication between brain regions and their connectivity pattern underlies proper brain function. Traumatic brain injury (TBI) damages white matter tracts and changes brain connectivity, but how specific changes relate to differences in clinical/behavioral outcomes is not known. Using network theory to study injury related changes in structural connectivity, we find that local measures of network structure can identify subgroups of injured rats with different types of changes in brain structure. Our results suggest that these different patterns of change could relate to differences in clinical outcomes.
Parent-of-origin effects in the life-course evolution of cardio-metabolic traits
Authors: Wagh Rucha , Kunte Pooja , Yajnik Chittaranjan S , Prasad Rashmi B 
Published: October 2021

AbstractObjectiveHuman traits are heritable, and some of these including metabolic and lipid phenotypes show preferential parental transmissions, or parent-of-origin effects. These have been mostly studied in populations comprising adults. We aimed to investigate heritability and parent-of-origin effects on cardiometabolic and anthropometric traits in a birth-cohort with serial measurements to assess if these effects manifested at an early age.Research design and methodsWe investigated heritability and parent-of-origin effects on cardiometabolic and anthropometric traits in the Pune Maternal Nutrition Study (PMNS) wherein offspring and parents were studied from birth and followed-up for 18 years. Heritability was estimated by calculating association between mid-parental phenotypes and offspring. Maternal and paternal effects on offspring phenotype were modelled by regression after adjusting for age, sex and BMI. Parent-of-origin effects were calculated by the difference between maternal and paternal effects.ResultsAnthropomorphic traits and cardiometabolic traits were robustly heritable. Parent-of-origin effects were observed for glycemic traits at both 6- and 12-years, with a paternal effect at 6-years which transitioned to a maternal effect at 12-years. For insulin and HOMA-S, a negative maternal effect transitioned to a positive one at 12-years. For HOMA-B, a paternal effect at 6-years transitioned to a maternal one at 12-years. Lipid traits consistently showed stronger maternal influence while anthropometric traits did not show any parental biases.ConclusionsOur study highlights that parental programming of cardiometabolic traits is evident from early childhood and can transition during puberty. Further studies are needed to determine the mechanisms of underlying such effects.
Dormant spores sense amino acids through the B subunits of their germination receptors
Authors: Artzi Lior , Alon Assaf , Brock Kelly P. , Green Anna G. , Tam Amy , Ramírez-Guadiana Fernando H. , Marks Debora , Kruse Andrew , Rudner David Z. 
Published: October 2021

AbstractBacteria from the orders Bacillales and Clostridiales differentiate into stress-resistant spores that can remain dormant for years, yet rapidly germinate upon nutrient sensing. How spores monitor nutrients is poorly understood but in most cases requires putative membrane receptors. The prototypical receptor from Bacillus subtilis consists of three proteins (GerAA, GerAB, GerAC) required for germination in response to L-alanine. GerAB belongs to the Amino Acid-Polyamine-Organocation superfamily of transporters. Using evolutionary co-variation analysis, we provide evidence that GerAB adopts a structure similar to an L-alanine transporter from this superfamily. We show that mutations in gerAB predicted to disrupt the ligand-binding pocket impair germination, while mutations predicted to function in L-alanine recognition enable spores to respond to L-leucine or L-serine. Finally, substitutions of bulkier residues at these positions cause constitutive germination. These data suggest that GerAB is the L-alanine sensor and that B subunits in this broadly conserved family function in nutrient detection.
Humanoid service robots versus human employee: how consumers react to functionally and culturally mixed products
Authors: Jiang Hongyan , Xu Mengmeng , Sun Peizhen , Zhang Jing 
Published: October 2021

PurposeMixed products, while presenting new business opportunities, raise considerable concerns among managers and researchers. However, whether mixed products (functionally vs culturally) trigger positive or negative consumer reactions is controversial. Hereby, the present research seeks to resolve the conflicting effects by examining the moderating role of service provider type (humanoid service robot vs human employee) in the impact of mixed products on consumer reactions.Design/methodology/approachTwo studies were conducted to explore the effect of mixed products on consumer reactions. Specifically, study 1 was developed to examine the interplay of mixed products and service provider type in shaping consumers' product attitudes and purchase intentions under an offline shopping scenario; study 2 further provided evidence for the mediating roles of perceived usefulness and perceived enjoyment in the above processes under an online-shopping context.FindingsThe convergent findings of two studies conclude that, when served by a humanoid service robot (vs human employee), consumers exhibit more positive attitudes and higher purchase intentions toward functionally (vs culturally) mixed products. Furthermore, such effect is driven by the perceived usefulness (vs perceived enjoyment) when served by humanoid robot (vs human employee).Originality/valueFirst, this is one of the first studies to conceptualize mixed products as the two-dimensional construct (i.e. functionally mixed and culturally mixed), and the findings sheds light on the mixed products literature. Second, this paper introduces service provider type as the boundary condition for the impact of mixed products on consumers' product attitudes and purchase intentions, which expands the match-up hypothesis and schema theory in service marketing. Third, the current research explores the mediating roles of perceived usefulness and perceived enjoyment in the above effects, which could make significant contribution to the motivation theory.
Time flies when chatting online: a social structure and social learning model to understand excessive use of mobile instant messaging
Authors: Wang Chuang , Zhang Jun , Lee Matthew K.O. 
Published: October 2021

PurposeWidespread concerns about excessive use of mobile instant messaging (MIM) have inspired research in different disciplines. However, the focus thus far tends to be on diagnostics and cognitive predictors. There is little understanding from the socio-technical perspective to capture the drivers of excessive use of MIM. To address this research gap, the authors aim to enrich existing literature by adopting a social structure and social learning model (SSSLM) to understand the excessive use of MIM. The authors argue that excessive MIM use is developed and reinforced in highly interactive online communication, through a social learning process.Design/methodology/approachThe authors conduct a cross-sectional online survey to validate our proposed research model on excessive use of mobile instant messaging (MIM). 368 valid responses are obtained from active MIM users in China.FindingsThe results suggest that highly interactive MIM creates a technology-based social structure that facilitates the social learning process of excessive technology use. The influence of perceived interactivity of MIM on excessive MIM use is mediated by a series of contextualized social learning factors. Furthermore, the influences of perceived interactivity on social learning factors are moderated by MIM use experience.Originality/valueThe authors contribute to literature in related fields by highlighting the crucial role of social learning in facilitating excessive technology use. The authors contribute to the social structure and social learning model by contextualizing it into the context of excessive MIM use. Design guidelines are provided with a purpose to inhibit excessive use of MIM.