bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies
Authors: Heidbuechel Johannes P. W. , Engeland Christine E. 
Published: April 2021

AbstractBispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that redirect T cells to tumor surface antigens. While efficacious against certain hematological malignancies, limited bioavailability and severe toxicities have so far hampered broader clinical application, especially against solid tumors. Another emerging cancer immunotherapy are oncolytic viruses (OVs) which selectively infect and replicate in malignant cells, thereby mediating tumor vaccination effects. These oncotropic viruses can serve as vectors for tumor-targeted immunomodulation and synergize with other immunotherapies. In this article, we discuss the use of OVs to overcome challenges in BiTE therapy. We review the current state of the field, covering published preclinical studies as well as ongoing clinical investigations. We systematically introduce OV-BiTE vector design and characteristics as well as evidence for immune-stimulating and anti-tumor effects. Moreover, we address additional combination regimens, including CAR T cells and immune checkpoint inhibitors, and further strategies to modulate the tumor microenvironment using OV-BiTEs. The inherent complexity of these novel therapeutics highlights the importance of translational research including correlative studies in early-phase clinical trials. More broadly, OV-BiTEs can serve as a blueprint for diverse OV-based cancer immunotherapies.
The effectiveness of PROLOTHERAPY for recalcitrant Medial TIBIAL Stress Syndrome: a prospective consecutive CASE series
Authors: Padhiar Nat , Curtin Mark , Aweid Osama , Aweid Bashaar , Morrissey Dylan , Chan Otto , Malliaras Peter , Crisp Tom 
Published: April 2021

AbstractBackgroundMedial tibial stress syndrome (MTSS) is one of the most common lower leg injuries in sporting populations. It accounts for between 6 and 16% of all running injuries, and up to 53% of lower leg injuries in military recruits. Various treatment modalities are available with varying degrees of success. In recalcitrant cases, surgery is often the only option.ObjectiveTo evaluate whether ultrasound‐guided injection of 15% dextrose for treatment of recalcitrant MTSS decreases pain and facilitates a return to desired activity levels for those who may otherwise be considering surgery or giving up the sport.MethodThe study design was a prospective consecutive case series involving eighteen patients: fifteen male and three female; (mean age = 31.2 years) with recalcitrant MTSS. They were referred from sports injury clinics across the UK, having failed all available conservative treatment.InterventionAn ultrasound‐guided sub‐periosteal injection of 15% dextrose was administered by the same clinician (NP) along the length of the symptomatic area. Typically, 1 mL of solution was injected per cm of the symptomatic area.Main outcome measuresPain was assessed using a 10‐cm visual analog scale (VAS) at baseline, short‐term, medium‐term (mean 18 weeks), and long‐term (mean 52 weeks) follow‐up. Symptom resolution and return to activity were measured using a Likert scale at medium and long‐term follow‐up. Statistical analyses were performed using SPSS for Mac version 19.0.0 (IBM, New York, NY, US). The Shapiro‐Wilk test was used to evaluate the normality of the distribution of data. Friedman's non‐parametric test was used to compare the within‐patient treatment response over time. Post‐hoc Wilcoxon signed‐rank tests with Bonferroni corrections were performed to determine VAS average pain response to treatment over five paired periods.ResultsPatients reported a significant (p < 0.01) reduction in median VAS pain score at medium and long‐term follow‐up compared to baseline. Median improvement per patient was 4.5/10. Patients rated their condition as ‘much improved’ at medium‐term follow‐up and the median return to sports score was ‘returned to desired but not pre‐injury level’ at medium‐term and long‐term follow‐up. No adverse events were reported.ConclusionsUltrasound‐guided 15% dextrose prolotherapy injection has a significant medium‐term effect on pain in MTSS. This benefit may be maintained long‐term; however, more robust trials are required to validate these findings in the absence of controls.Clinical relevanceClinicians should consider the use of ultrasound‐guided injection of 15% dextrose as a viable treatment option to reduce pain and aid return to activity for patients with recalcitrant MTSS.
Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis
Authors: Owen Victoria S. , Rosgen Brianna K. , Cherak Stephana J. , Ferland Andre , Stelfox Henry T. , Fiest Kirsten M. , Niven Daniel J. 
Published: April 2021

AbstractBackgroundIt is unclear whether vasopressors can be safely administered through a peripheral intravenous (PIV). Systematic review and meta-analysis methodology was used to examine the incidence of local anatomic adverse events associated with PIV vasopressor administration in patients of any age cared for in any acute care environment.MethodsMEDLINE, EMBASE, CINAHL, the Cochrane Central Register of controlled trials, and the Database of Abstracts of Reviews of Effects were searched without restriction from inception to October 2019. References of included studies and related reviews, as well as relevant conference proceedings were also searched. Studies were included if they were: (1) cohort, quasi-experimental, or randomized controlled trial study design; (2) conducted in humans of any age or clinical setting; and (3) reported on local anatomic adverse events associated with PIV vasopressor administration. Risk of bias was assessed using the Revised Cochrane risk-of-bias tool for randomized trials or the Joanna Briggs Institute checklist for prevalence studies where appropriate. Incidence estimates were pooled using random effects meta-analysis. Subgroup analyses were used to explore sources of heterogeneity.ResultsTwenty-three studies were included in the systematic review, of which 16 and 7 described adults and children, respectively. Meta-analysis from 11 adult studies including 16,055 patients demonstrated a pooled incidence proportion of adverse events associated with PIV vasopressor administration as 1.8% (95% CI 0.1–4.8%,I2 = 93.7%). In children, meta-analysis from four studies and 388 patients demonstrated a pooled incidence proportion of adverse events as 3.3% (95% CI 0.0–10.1%,I2 = 82.4%). Subgroup analyses did not detect any statistically significant effects associated with stratification based on differences in clinical location, risk of bias or design between studies, PIV location and size, or vasopressor type or duration. Most studies had high or some concern for risk of bias.ConclusionThe incidence of adverse events associated with PIV vasopressor administration is low. Additional research is required to examine the effects of PIV location and size, vasopressor type and dose, and patient characteristics on the safety of PIV vasopressor administration.
A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
Authors: Jones Wendell , Gong Binsheng , Novoradovskaya Natalia , Li Dan , Kusko Rebecca , Richmond Todd A. , Johann Donald J. , Bisgin Halil , Sahraeian Sayed Mohammad Ebrahim , Bushel Pierre R. , Pirooznia Mehdi , Wilkins Katherine , Chierici Marco , Bao Wenjun , Basehore Lee Scott , Lucas Anne Bergstrom , Burgess Daniel , Butler Daniel J. , Cawley Simon , Chang Chia-Jung , Chen Guangchun , Chen Tao , Chen Yun-Ching , Craig Daniel J. , del Pozo Angela , Foox Jonathan , Francescatto Margherita , Fu Yutao , Furlanello Cesare , Giorda Kristina , Grist Kira P. , Guan Meijian , Hao Yingyi , Happe Scott , Hariani Gunjan , Haseley Nathan , Jasper Jeff , Jurman Giuseppe , Kreil David Philip , Łabaj Paweł , Lai Kevin , Li Jianying , Li Quan-Zhen , Li Yulong , Li Zhiguang , Liu Zhichao , López Mario Solís , Miclaus Kelci , Miller Raymond , Mittal Vinay K. , Mohiyuddin Marghoob , Pabón-Peña Carlos , Parsons Barbara L. , Qiu Fujun , Scherer Andreas , Shi Tieliu , Stiegelmeyer Suzy , Suo Chen , Tom Nikola , Wang Dong , Wen Zhining , Wu Leihong , Xiao Wenzhong , Xu Chang , Yu Ying , Zhang Jiyang , Zhang Yifan , Zhang Zhihong , Zheng Yuanting , Mason Christopher E. , Willey James C. , Tong Weida , Shi Leming , Xu Joshua 
Published: April 2021

Abstract
Background
Oncopanel genomic testing, which identifies important somatic variants, is increasingly common in medical practice and especially in clinical trials. Currently, there is a paucity of reliable genomic reference samples having a suitably large number of pre-identified variants for properly assessing oncopanel assay analytical quality and performance. The FDA-led Sequencing and Quality Control Phase 2 (SEQC2) consortium analyze ten diverse cancer cell lines individually and their pool, termed Sample A, to develop a reference sample with suitably large numbers of coding positions with known (variant) positives and negatives for properly evaluating oncopanel analytical performance.

Results
In reference Sample A, we identify more than 40,000 variants down to 1% allele frequency with more than 25,000 variants having less than 20% allele frequency with 1653 variants in COSMIC-related genes. This is 5–100× more than existing commercially available samples. We also identify an unprecedented number of negative positions in coding regions, allowing statistical rigor in assessing limit-of-detection, sensitivity, and precision. Over 300 loci are randomly selected and independently verified via droplet digital PCR with 100% concordance. Agilent normal reference Sample B can be admixed with Sample A to create new samples with a similar number of known variants at much lower allele frequency than what exists in Sample A natively, including known variants having allele frequency of 0.02%, a range suitable for assessing liquid biopsy panels.

Conclusion
These new reference samples and their admixtures provide superior capability for performing oncopanel quality control, analytical accuracy, and validation for small to large oncopanels and liquid biopsy assays.
Establishment of a Japanese version of the Sick, Control, One Stone, Fat, and Food (SCOFF) questionnaire for screening eating disorders in university students
Authors: Hosoda Yutaka , Ohtani Toshiyuki , Hanazawa Hisashi , Tanaka Mami , Kimura Hiroshi , Ohsako Noriaki , Hashimoto Tasuku , Kobori Osamu , Iyo Masaomi , Nakazato Michiko 
Published: April 2021

AbstractObjectiveThis study aimed to validate the Sick, Control, One stone, Fat, and Food (SCOFF) questionnaire in relation to the Eating Disorders Examination Questionnaire (EDE-Q) and to examine the appropriateness of a question concerning weight loss among Japanese university students. The psychometric properties of the two Japanese versions were determined among 649 Japanese college students. The original version (SCOFF-O) employed the original item 3, whereas the revised version (SCOFF-2.5) modified the item to “Have you recently lost more than 2.5 kg within three months?” Validity was tested relative to EDE-Q.ResultsThe test–retest reliabilities of SCOFF-O and SCOFF-2.5 were 0.52 and 0.57, while the correlations of SCOFF-O and SCOFF-2.5 with EDE-Q werer = 0.53 andr = 0.56. The sensitivity and specificity of SCOFF-O were 65.2 and 89.7, and those of SCOFF-2.5 were 69.5 and 86.5, respectively. There were significant correlations between the question concerning losing 2.5 kg and the EDE-Q subscales. The Japanese version of SCOFF-2.5 is an appropriate tool for the early screening of eating disorders among Japanese university students.
Abdominal aortic aneurysm and acute appendicitis: a case report and review of the literature
Authors: Peña Rubén , Valverde Sergio , Alcázar José A. , Cebrián Paloma , González-Porras José Ramón , Lozano Francisco S. 
Published: April 2021

Abstract
Background
Abdominal aortic aneurysm and acute appendicitis occur relatively frequently in elderly patients. However, the co-occurrence of the two pathologies is very rare and serious.

Case presentation
We present the case of an elderly Caucasian patient who was aware of having an abdominal aortic aneurysm but refused treatment and was subsequently admitted to the hospital’s emergency department with acute abdominal symptoms. A computed tomography scan raised the possibility of complication due to the characteristics of the aneurysm. The patient then agreed to emergency surgery. Laparotomy revealed the existence of an acute perforated appendicitis with a significant abscess in the right iliac fossa and an uncomplicated aneurysm. Appendectomy was performed and the abscess drained. The postoperative period passed without complications, and the patient again refused surgery for the aneurysm, which due to its anatomical characteristics was not a candidate for standard endovascular treatment.

Conclusions
In light of this experience, we review the literature about the relationship between abdominal aortic aneurysm and acute appendicitis.
A novel MSC-based immune induction strategy for ABO-incompatible liver transplantation: a phase I/II randomized, open-label, controlled trial
Authors: Zhang Yingcai , Zhang Jiebin , Yi Huimin , Zheng Jun , Cai Jianye , Chen Wenjie , Lu Tongyu , Chen Liang , Du Cong , Liu Jianrong , Yao Jia , Zhao Hui , Wang Guoying , Fu Binsheng , Zhang Tong , Zhang Jian , Wang Genshu , Li Hua , Xiang Andy Peng , Chen Guihua , Yi Shuhong , Zhang Qi , Yang Yang 
Published: April 2021

Abstract
Background
ABO-incompatible liver transplantation (ABO-i LT) has become a rescue therapeutic option for patients with severe hepatic failure. Although the use of rituximab greatly reduces the morbidity of antibody-mediated rejection (AMR), severe adverse effects, such as infection and biliary complications, still seriously threaten the survival of transplant recipients. The aim of this study was to evaluate the safety and feasibility of using mesenchymal stem cells (MSCs) to replace rituximab in ABO-i LT.

Methods
Twenty-two patients with severe hepatic failure undergoing ABO-i LT were enrolled and randomly divided into two groups: the MSC group and the rituximab group. The safety of the application of MSCs and the incidence of allograft rejection, including antibody-mediated rejection (AMR) and acute cellular rejection (ACR), were evaluated in both groups at the 2-year follow-up period as primary endpoints. Recipients and graft survival and other postoperative complications were compared as secondary endpoints.

Results
No severe MSC-related adverse events were observed during the trial. MSC treatment yielded comparable, if not better, results than rituximab at decreasing the incidence of acute rejection (9.1% vs 27.3%). Inspiringly, compared to those in the rituximab group, the rates of biliary complications (0% vs 45.5%) and infection (9.1% vs 81.8%) were significantly decreased in the MSC group. In addition, there were no significant differences in 2-year graft and recipient survival between the two groups (81.8% vs 72.7%).

Conclusions
Our data show that MSC transfusion is comparable to rituximab treatment for AMR prophylaxis following ABO-i LT. Additionally, the results indicate that MSCs are more beneficial to the prevention of infection and biliary complications and may be introduced as a novel immunosuppressive approach for ABO-i LT.

Trial registration
Trial registration: chictr.org.cn, ChiCTR2000037732. Registered 31 August 2020- Retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj=57074.
IDSDL: a sensitive intrusion detection system based on deep learning
Authors: Hu Yanjun , Bai Fan , Yang Xuemiao , Liu Yafeng 
Published: April 2021

AbstractDevice-free passive (DfP) intrusion detection system is a system that can detect moving entities without attaching any device to the entities. To achieve good performance, the existing algorithms require proper access point (AP) deployment. It limits the applying scenario of those algorithms. We propose an intrusion detection system based on deep learning (IDSDL) with finer-grained channel state information (CSI) to free the AP position. A CSI phase propagation components decomposition algorithm is applied to obtain blurred components of CSI phase on several paths as a more sensitive detection signal. Convolutional neuron network (CNN) of deep learning is used to enable the computer to learn and detect intrusion without extracting numerical features. We prototype IDSDL to verify its performance and the experimental results indicate that IDSDL is effective and reliable.
Overcontrolled, undercontrolled, and resilient personality styles among patients with eating disorders
Authors: Isaksson Martina , Ghaderi Ata , Wolf-Arehult Martina , Ramklint Mia 
Published: April 2021

Abstract
Background
Personality has been suggested to be an important factor in understanding onset, maintenance, and recovery from eating disorders (ED). The objective of the current study was to evaluate personality style in different ED diagnostic groups as classified in the Diagnostic and Statistical Manual of Mental Disorders, Fifth edition (DSM-5).

Methods
The overcontrolled, undercontrolled, and resilient personality styles were compared in four groups of patients with EDs: anorexia nervosa restricting (ANr) (n = 34), anorexia nervosa binge eating/purging (ANbp) (n = 31), atypical anorexia nervosa (AAN) (n = 29), and bulimia nervosa (BN) (n = 76). These groups were compared with a group of patients with borderline personality disorder (BPD) (n = 108), and a non-clinical group (NC) (n = 444). Patient data were collected at two outpatient clinics in Uppsala, Sweden. NC control data were collected through convenience sampling. Participants filled out questionnaires assessing personality style.

Results
The main findings were more pronounced overcontrol reported by the ANr and AAN groups compared with the BN, BPD, and NC groups, and no significant difference in resilience between the ED and the NC groups. Considerable variability of over- and undercontrol was also found within each group.

Conclusions
The results replicate previous findings when EDs are classified according to current diagnostic criteria (DSM-5). Taking personality styles into account may improve our understanding of certain characteristics in EDs, such as social deficits and rigidity that are attributed to poor treatment outcome.
MEK inhibitors - novel targeted therapies of neurofibromatosis associated benign and malignant lesions
Authors: Harder Anja 
Published: April 2021

AbstractMAP/ERK kinase 1 and 2 (MEK 1/2) inhibitors (MEKi) are investigated in several trials to treat lesions that arise from pathogenic variants of the Neurofibromatosis type 1 and type 2 genes (NF1, NF2). These trials showed that MEKi are capable to shrink volume of low grade gliomas and plexiform neurofibromas in NF1. Targeting other lesions being associated with a high morbidity in NF1 seems to be promising. Due to involvement of multiple pathways in NF2 associated lesions as well as in malignant tumors, MEKi are also used in combination therapies. This review outlines the current state of MEKi application in neurofibromatosis and associated benign and malignant lesions.
Noise classification for the unified earthquake catalog using ensemble learning: the enhanced image of seismic activity along the Japan Trench by the S-net seafloor network
Authors: Tamaribuchi Koji , Hirose Fuyuki , Noda Akemi , Iwasaki Yuriko , Iwakiri Kazuhiro , Ueno Hiroshi 
Published: April 2021

AbstractHomogeneous and accurate hypocenter distribution along the Japan Trench is important to better understand the process of plate subduction and the occurrence mode of large earthquakes. The seafloor seismic network (S-net) deployed recently along the Japan Trench has revealed new seismic activity including shallow slow earthquakes. However, conventional microseismic observations, such as those reported in the Japan Meteorological Agency (JMA) unified earthquake catalog, have been limited to land-based stations. Thus, steady seismic activity occurring at the shallow plate boundary, which is far from land is not always recorded. In the present study, we construct an automatic earthquake catalog using the nationwide observation network, including S-net. Because false detections caused by noise account for about 5% of automatically determined hypocenters, we attempted to reduce false detections using ensemble learning methods such as random forest and AdaBoost. First, we created a training dataset of earthquakes and noise by visual inspection based on the data recorded in the automatically determined catalog over a 2-month period, and we trained the dataset using the hypocenter and phase data as input. As a result of the training, AdaBoost was able to reduce the noise to about one-fifth of the total false detections, which is equivalent to 1%, while keeping the number of hypocenters above 99%. This method will contribute to significantly improving the efficiency of seismic activity monitoring and cataloging. In addition, the automatic denoised catalog data revealed that from January to August 2020, the completeness magnitude wasM1.6 along the Japan Trench. These microearthquakes were concentrated at depths of 20–50 km around the upper surface of the subducting Pacific Plate and are complementary to the slow earthquakes occurring at 10–20-km depths. Exceptionally, microearthquakes were observed off Iwate and Ibaraki prefectures, which correspond in location to areas of clustered foreshock activity. This spatial heterogeneity in microseismic activity is similar to the spatial complementary between the coseismic slip and afterslip of the 2011 Tohoku earthquake, which may be related to differences in interplate frictional properties and stress changes in the surrounding crust.