bluuebunny/crossref_metadata_2025_split huggingface dataset:
Charged and neutral $$ {\overline{B}}_{u,d,s} $$ → γ form factors from light cone sum rules at NLO
Authors: Janowski Tadeusz , Pullin Ben , Zwicky Roman 
Published: December 2021

Abstract
We present the first analytic $$ \mathcal{O}\left({\alpha}_s\right) $$
O

α
s

-computation at twist-1,2 of the $$ {\overline{B}}_{u,d,s} $$

B
¯

u
,
d
,
s

→ γ form factors within the framework of sum rules on the light-cone. These form factors describe the charged decay $$ {\overline{B}}_u\to \gamma {\mathrm{\ell}}^{-}\overline{v} $$

B
¯

u

→
γ

ℓ
−

v
¯

, contribute to the flavour changing neutral currents $$ {\overline{B}}_{d,s}\to \gamma {\mathrm{\ell}}^{+}{\mathrm{\ell}}^{-} $$

B
¯

d
,
s

→
γ

ℓ
+

ℓ
−

and serve as inputs to more complicated processes. We provide a fit in terms of a z-expansion with correlation matrix and extrapolate the form factors to the kinematic endpoint by using the gBB*γ couplings as a constraint. Analytic results are available in terms of multiple polylogarithms in the supplementary material. We give binned predictions for the $$ {\overline{B}}_u\to \gamma {\mathrm{\ell}}^{-}\overline{v} $$

B
¯

u

→
γ

ℓ
−

v
¯

branching ratio along with the associated correlation matrix. By comparing with three SCET-computations we extract the inverse moment B-meson distribution amplitude parameter λB = 360(110) MeV. The uncertainty thereof could be improved by a more dedicated analysis. In passing, we extend the photon distribution amplitude to include quark mass corrections with a prescription for the magnetic vacuum susceptibility, χq, compatible with the twist-expansion. The values χq = 3.21(15) GeV−2 and χs = 3.79(17) GeV−2 are obtained.
Evaluation of circulating microRNAs as non-invasive biomarkers in the diagnosis of ovarian cancer: a case–control study
Authors: Berner Kai , Hirschfeld Marc , Weiß Daniela , Rücker Gerta , Asberger Jasmin , Ritter Andrea , Nöthling Claudia , Jäger Markus , Juhasz-Böss Ingolf , Erbes Thalia 
Published: December 2021

Abstract
Purpose
Ovarian cancer is the seventh most frequent form of malignant diseases in women worldwide and over 150,000 women die from it every year. More than 70 percent of all ovarian cancer patients are diagnosed at a late-stage disease with poor prognosis necessitating the development of sufficient screening biomarkers. MicroRNAs displayed promising potential as early diagnostics in various malignant diseases including ovarian cancer. The presented study aimed at identifying single microRNAs and microRNA combinations detecting ovarian cancer in vitro and in vivo.

Methods
Intracellular, extracellular and urinary microRNA expression levels of twelve microRNAs (let-7a, let-7d, miR-10a, miR-15a, miR-15b, miR-19b, miR-20a, miR-21, miR-100, miR-125b, miR-155, miR-222) were quantified performing quantitative real-time-PCR. Therefore, the three ovarian cancer cell lines SK-OV-3, OAW-42, EFO-27 as well as urine samples of ovarian cancer patients and healthy controls were analyzed.

Results
MiR-15a, miR-20a and miR-222 showed expression level alterations extracellularly, whereas miR-125b did intracellularly across the analyzed cell lines. MicroRNA expression alterations in single cell lines suggest subtype specificity in both compartments. Hypoxia and acidosis showed scarce effects on single miRNA expression levels only. Furthermore, we were able to demonstrate the feasibility to clearly detect the 12 miRNAs in urine samples. In urine, miR-15a was upregulated whereas let-7a was down-regulated in ovarian cancer patients.

Conclusion
Intracellular, extracellular and urinary microRNA expression alterations emphasize their great potential as biomarkers in liquid biopsies. Especially, miR-15a and let-7a qualify for possible circulating biomarkers in liquid biopsies of ovarian cancer patients.
The long and intertwined record of humans and the Campi Flegrei volcano (Italy)
Authors: Costa A. , Di Vito M. A. , Ricciardi G. P. , Smith V. C. , Talamo P. 
Published: December 2021

AbstractThe Campi Flegrei volcano (or Phlegraean Fields), Campania, Italy, generated the largest eruption in Europe in at least 200 ka. Here we summarise the volcanic and human history of Campi Flegrei and discuss the interactions between humans and the environment within the “burning fields” from around 10,000 years until the 1538 CE Monte Nuovo eruption and more recent times. The region’s incredibly rich written history documents how the landscape changed both naturally and anthropogenically, with the volcanic system fuelling these considerable natural changes. Humans have exploited the beautiful landscape, accessible resources (e.g. volcanic ash for pulvis puteolana mortar) and natural thermal springs associated with the volcano for millennia, but they have also endured the downsides of living in a volcanically active region—earthquakes, significant ground deformation and landscape altering eruptions. The pre-historic record is detailed, and various archaeological sites indicate that the region was certainly occupied in the last 10,000 years. This history has been reconstructed by identifying archaeological finds in sequences that often contain ash (tephra) layers from some of the numerous volcanic eruptions from Campi Flegrei and the other volcanoes in the region that were active at the time (Vesuvius and Ischia). These tephra layers provide both a relative and absolute chronology and allow the archaeology to be placed on a relatively precise timescale. The records testify that people have inhabited the area even when Campi Flegrei was particularly active. The archaeological sequences and outcrops of pyroclastic material preserve details about the eruption dynamics, buildings from Roman times, impressive craters that now host volcanic lakes and nature reserves, all of which make this region particularly mystic and fascinating, especially when we observe how society continues to live within the active caldera system. The volcanic activity and long record of occupation and use of volcanic resources in the region make it unique and here we outline key aspects of its geoheritage.
Approximation of partial differential equations on compact resistance spaces
Authors: Hinz Michael , Meinert Melissa 
Published: December 2021

AbstractWe consider linear partial differential equations on resistance spaces that are uniformly elliptic and parabolic in the sense of quadratic forms and involve abstract gradient and divergence terms. Our main interest is to provide graph and metric graph approximations for their unique solutions. For families of equations with different coefficients on a single compact resistance space we prove that solutions have accumulation points with respect to the uniform convergence in space, provided that the coefficients remain bounded. If in a sequence of equations the coefficients converge suitably, the solutions converge uniformly along a subsequence. For the special case of local resistance forms on finitely ramified sets we also consider sequences of resistance spaces approximating the finitely ramified set from within. Under suitable assumptions on the coefficients (extensions of) linearizations of the solutions of equations on the approximating spaces accumulate or even converge uniformly along a subsequence to the solution of the target equation on the finitely ramified set. The results cover discrete and metric graph approximations, and both are discussed.
Dural tear repair surgery comparative analysis: a stitch in time saves nine
Authors: Taylor Charles , Khan Amad , Shenouda Emad , Brooke Nicholas , Nader-Sepahi Ali 
Published: December 2021

Abstract
Purpose
A dural tear is a common iatrogenic complication of spinal surgery associated with a several post-operative adverse events. Despite their common occurrence, guidelines on how best to repair the defect remain unclear. This study uses five post-operative outcomes to the compare repair methods used to treat 106 dural tears to determine which method is clinically favourable.

Methods
Data were retrospectively collected from Southampton General Hospital’s online databases. 106 tears were identified and grouped per repair method. MANOVA was used to compare the following five outcomes: Length of stay, numbers of further admissions or revision surgeries, length of additional admissions, post-operative infection rate and dural tear associated neurological symptoms. Sub-analysis was conducted on patient demographics, primary vs non-primary closure and type of patch. Minimal clinically important difference (MCID) was calculated via the Delphi procedure.

Results
Age had a significant impact on patient outcomes and BMI displayed positive correlation with three-fifth of the predefined outcome measures. No significant difference was observed between repair groups; however, primary closure ± a patch achieved an MCID percentage improvement with regards to length of original stay, rate of additional admissions/surgeries and post-operative infection rate. Artificial over autologous patches resulted in shorter hospital stays, fewer readmissions, infections and neurological symptoms.

Conclusion
This study reports primary closure ± dural patch as the most efficient repair method with regards to the five reported outcomes. This study provides limited evidence in favour of artificial over autologous patches and recommends that dural patches be used in conjunction with primary closure.

Level of evidence I
Diagnostic: individual cross-sectional studies with consistently applied reference standard and blinding.
Anterior occlusion in shortened dental arches
Authors: Pacek Elżbieta , Walter Michael H. 
Published: December 2021

Abstract
Objectives
The aim of this study was to examine the occlusion of anterior teeth in individuals with shortened dental arch (SDA).

Material and methods
In a case–control clinical study, 41 individuals with SDA and 41 individuals with complete dental arch (CDA) participated. The CDA control group was matched for age and gender. Testing for occlusal contacts of anterior maxillary teeth was conducted by biting on foil strips (8 µm) with subjectively normal bite force (NBF) and maximal bite force (MBF). The data was analyzed on individual and tooth levels.

Results
The median rates of anterior maxillary teeth with occlusal contacts were 0.67 (NBF) and 0.83 (MBF) in the SDA group and 0.50 (NBF) and 0.83 (MBF) in the CDA group. Within both groups, the contact rates were significantly higher in MBF. The group difference with NBF was significant. A generalized linear model showed that the odds of an anterior maxillary tooth to have an occlusal contact were greater in the SDA both for NBF with an odds ratio (OR) 2.277 and MBF with an OR 1.691.

Conclusions
The findings suggest effective compensatory mechanisms relative to the occlusal function in individuals with SDA.

Clinical relevance
The study delivers further evidence regarding the SDA concept as a viable option in the management of posterior tooth loss.
The Concept of Evenness/Unevenness: Less Evenness or More Unevenness?
Authors: Gregorius Hans-Rolf , Gillet Elizabeth M. 
Published: December 2021

AbstractWhile evenness is understood to be maximal if all types (species, genotypes, alleles, etc.) are represented equally (via abundance, biomass, area, etc.), its opposite, maximal unevenness, either remains conceptually in the dark or is conceived as the type distribution that minimizes the applied evenness index. The latter approach, however, frequently leads to conceptual inconsistency due to the fact that the minimizing distribution is not specifiable or is monomorphic. The state of monomorphism, however, is indeterminate in terms of its evenness/unevenness characteristics. Indeed, the semantic indeterminacy also shows up in the observation that monomorphism represents a state of pronounced discontinuity for the established evenness indices. This serious conceptual inconsistency is latent in the widely held idea that evenness is an independent component of diversity. As a consequence, the established evenness indices largely appear as indicators of relative polymorphism rather than as indicators of evenness. In order to arrive at consistent measures of evenness/unevenness, it seems indispensable to determine which states are of maximal unevenness and then to assess the position of a given type distribution between states of maximal evenness and maximal unevenness. Since semantically, unevenness implies inequality among type representations, its maximum is reached if all type representations are equally different. For given number of types, this situation is realized if type representations, when ranked in descending order, show equal differences between adjacent types. We term such distributions “stepladders” as opposed to “plateaus” for uniform distributions. Two approaches to new evenness measures are proposed that reflect different perspectives on the positioning of type distributions between the closest stepladders and the closest plateaus. Their two extremes indicate states of complete evenness and complete unevenness, and the midpoint is postulated to represent the turning point between prevailing evenness and prevailing unevenness. The measures are graphically illustrated by evenness surfaces plotted above frequency simplices for three types, and by transects through evenness surfaces for more types. The approach can be generalized to include variable differences between types (as required in analyses of functional evenness) by simply replacing types with pairs of different types. Pairs, as the new types, can be represented by their abundances, for example, and these can be modified in various ways by the differences between the two types that form the pair. Pair representations thus consist of both the difference between the paired types and their frequency. Omission of pair frequencies leads to conceptual ambiguity. Given this specification of pair representations, their evenness/unevenness can be evaluated using the same indices developed for simple types. Pair evenness then turns out to quantify dispersion evenness.
A chemorepulsion model with superlinear production: analysis of the continuous problem and two approximately positive and energy-stable schemes
Authors: Guillén-González F. , Rodríguez-Bellido M. A. , Rueda-Gómez D. A. 
Published: December 2021

AbstractWe consider the following repulsive-productive chemotaxis model: find u ≥ 0, the cell density, and v ≥ 0, the chemical concentration, satisfying
$$ \left\{ \begin{array}{l} \partial_t u - {\Delta} u - \nabla\cdot (u\nabla v)=0 \ \ \text{ in}\ {\Omega},\ t>0,\\ \partial_t v - {\Delta} v + v = u^p \ \ { in}\ {\Omega},\ t>0, \end{array} \right. $$

∂

t

u
−
Δ
u
−
∇
⋅
(
u
∇
v
)
=
0

in

Ω
,

t
>
0
,

∂

t

v
−
Δ
v
+
v
=

u

p

i
n

Ω
,

t
>
0
,

with p ∈ (1, 2), ${\Omega }\subseteq \mathbb {R}^{d}$
Ω
⊆

ℝ

d

a bounded domain (d = 1, 2, 3), endowed with non-flux boundary conditions. By using a regularization technique, we prove the existence of global in time weak solutions of (1) which is regular and unique for d = 1, 2. Moreover, we propose two fully discrete Finite Element (FE) nonlinear schemes, the first one defined in the variables (u,v) under structured meshes, and the second one by using the auxiliary variable σ = ∇v and defined in general meshes. We prove some unconditional properties for both schemes, such as mass-conservation, solvability, energy-stability and approximated positivity. Finally, we compare the behavior of these schemes with respect to the classical FE backward Euler scheme throughout several numerical simulations and give some conclusions.
Exposure Quality in Cognitive Behavioral Treatment for Youth Anxiety Disorders—Predictors and Associations with Outcomes
Authors: Fjermestad Krister W. , Ditlefsen Nina , Unsvåg Marie H. , Öst Lars-Göran , Havik Odd E. , Wergeland Gro Janne 
Published: December 2021

AbstractTo optimize cognitive behavioral therapy (CBT) outcomes for anxiety disorders in youth, more knowledge is needed about how specific CBT components work. Exposure to feared situations is an effective CBT component. However, there is little observation-based empirical research on how exposure relates to outcomes and other clinical variables. In a randomized controlled community clinic trial for youth with anxiety disorders, observers reliably rated exposure quality for 68 youths aged 8 to 15 years based on 118 videotaped sessions. The treatment program was the manual-based FRIENDS program. Three exposure quality elements (preparation, post-processing, and parent contribution to exposure) were examined in relation to pre-treatment demographic and clinical variables, outcomes, and youth- and therapist-rated alliance using multilevel hierarchical regression models. The outcomes were diagnostic recovery, clinical severity and anxiety symptoms change from pre- to post-treatment and one-year follow-up, and treatment dropout. The results showed that parent contribution to exposure was higher for boys and younger children. Parent contribution to exposure, but no other exposure element, was associated with a larger likelihood of diagnostic recovery and larger clinical severity reduction at one-year follow-up. Exposure quality was unrelated to outcomes at post-treatment, dropout, or alliance. We conclude that enhancing parent contribution to exposure during treatment could improve long-term outcomes after CBT for youth anxiety disorders. Exposure elements should be observed in larger samples to further examine their potential role for CBT outcomes.
Characterization of oxidation of glutathione by cytochrome c
Authors: Csomó K. B. , B B. Alasztics , Sándor A. P. , Belik A. A. , Varga G. , Hrabák A. , Kukor Z. 
Published: December 2021

AbstractCytochrome c is a member of the respiratory chain of the mitochondria. Non-membrane-bound (free) cytochrome c can be reduced by gluthatione as well as ascorbic acid. We investigated the effect of pH, Ca2+, Mg2+and anionic phospholipids on the reduction of cytochrome c by glutathione.The reduction of cytochrome c by thiols was measured using photometry. Mitochondrial oxygen consumption was detected by use of oxygen electrode. Glutathione does not reduce cytochrome c at pH = 7.0 in the absence of Ca2+and Mg2+. The reduction of cytochrome c by glutathione is inhibited by anionic lipids, especially cardiolipin. The typical conditions of apoptosis—elevated pH, Ca2+level and Mg2+—increases the reduction of cytochrome c. Glutathione (5 mM) causes increased mitochondrial O2consumption at pH = 8.0, in the presence of ADP either 1 mM Mg2+or 1 mM Ca2+. Our results suggest that membrane bound cyt c does not oxidize glutathione. Free (not membrane bound) cytochrome c can oxidize glutathione. In mitochondria, O2is depleted only in the presence of ADP, so the O2depletion observed in the presence of glutathione can be related to the respiratory chain. Decreased glutathione levels play a role in apoptosis. Therefore, membrane unbound cyt c can contribute to apoptosis by oxidation of glutathione.
Case Series: Convalescent Plasma Therapy for Patients with COVID-19 and Primary Antibody Deficiency
Authors: Lang-Meli Julia , Fuchs Jonas , Mathé Philipp , Ho Hsi-en , Kern Lisa , Jaki Lena , Rusignuolo Giuseppe , Mertins Susanne , Somogyi Vivien , Neumann-Haefelin Christoph , Trinkmann Frederik , Müller Michael , Thimme Robert , Umhau Markus , Quinti Isabella , Wagner Dirk , Panning Marcus , Cunningham-Rundles Charlotte , Laubner Katharina , Warnatz Klaus 
Published: December 2021

AbstractPatients with primary antibody deficiency are at risk for severe and in many cases for prolonged COVID-19. Convalescent plasma treatment of immunocompromised individuals could be an option especially in countries with limited access to monoclonal antibody therapies. While studies in immunocompetent COVID19 patients have demonstrated only a limited benefit, evidence for the safety, timing, and effectiveness of this treatment in antibody-deficient patients is lacking. Here, we describe 16 cases with primary antibody deficiency treated with convalescent plasma in four medical centers. In our cohort, treatment was associated with a reduction in viral load and improvement of clinical symptoms, even when applied over a week after onset of infection. There were no relevant side effects besides a short-term fever reaction in one patient. Longitudinal full-genome sequencing revealed the emergence of mutations in the viral genome, potentially conferring an antibody escape in one patient with persistent viral RNA shedding upon plasma treatment. However, he resolved the infection after a second course of plasma treatment. Thus, our data suggest a therapeutic benefit of convalescent plasma treatment in patients with primary antibody deficiency even months after infection. While it appears to be safe, PCR follow-up for SARS-CoV-2 is advisable and early re-treatment might be considered in patients with persistent viral shedding.
Evaluation of muscle-specific and metabolism regulating microRNAs in a chronic swimming rat model
Authors: Gaál Zsuzsanna , Fodor János , Oláh Attila , Radovits Tamás , Merkely Béla , Magyar János , Csernoch László 
Published: December 2021

AbstractMaking benefit from the epigenetic effects of environmental factors such as physical activity may result in a considerable improvement in the prevention of chronic civilization diseases. In our chronic swimming rat model, the expression levels of such microRNAs were characterized, that are involved in skeletal muscle differentiation, hypertrophy and fine-tuning of metabolism, which processes are influenced by chronic endurance training, contributing to the metabolic adaptation of skeletal muscle during physical activity. After chronic swimming, the level of miR-128a increased significantly in EDL muscles, which may influence metabolic adaptation and stress response as well. In SOL, the expression level of miR-15b and miR-451 decreased significantly after chronic swimming, which changes are opposite to their previously described increment in insulin resistant skeletal muscle. MiR-451 also targets PGC-1α mRNA, whiches expression level significantly increased in SOL muscles, resulting in enhanced biogenesis and oxidative capacity of mitochondria. In summary, the microRNA expression changes that were observed during our experiments suggest that chronic swim training contributes to a beneficial metabolic profile of skeletal muscle.
How did the Sarbanes–Oxley Act affect managerial incentives? Evidence from corporate acquisitions
Authors: Hillier David , McColgan Patrick , Tsekeris Athanasios 
Published: December 2021

AbstractWe examine the impact of incentive compensation on the riskiness of acquisition decisions before and after the passage of the Sarbanes–Oxley Act (SOX). Before SOX, equity-based compensation was positively related to changes in risk around acquisition decisions, but this relationship weakened after the introduction of SOX. The drop in post-SOX acquisition-related risk stems from how managers respond to compensation-based incentives in the new regulatory environment. We show that executive stock options and pay-risk sensitivity drive post-SOX managerial responsiveness to risk-taking incentives. We also document a post-SOX value-enhancing effect on long-term stock-price performance and total factor productivity through these same incentive compensation mechanisms. The results are robust to selection bias, simultaneity, measurements of risk, and the definition of incentive compensation.