bluuebunny/crossref_metadata_2025_split huggingface dataset:
Municipal infrastructure management using smart city landscape design and sustainable architecture technologies
Authors: Geng Zhirong , Zhu Zunling 
Published: June 2021

PurposeThe purpose of this paper is to investigate Chinese municipal infrastructure management using urban landscape design smart technologies and to propose an adaptive approach to introduce the best policy and architectural sustainable planning in the country.Design/methodology/approachThe topic of urban environment design is deemed significant as no universal model for the implementation of landscape design ideas in China have been proposed yet.FindingsThe study presents the authors' socioeconomic and socio-ecological vision of the strategies closely related to sustainable development concept. Besides, the paper provides a comparative analysis of the developed vision and other studies' approaches to determining Chinese cities' readiness for the implementation of smart services, architectural and territorial planning in conformity with the laws of nature. The study uncovered the main directions and residents' preferences for the introduction of urban environment design technologies in the cities of China for sustainable management of territories.Originality/valueStep-by-step recommendations were developed for municipal infrastructure management. The article proposes directions for sustainable architectural planning and urban landscape design in compliance with the principle of harmonious human–nature coexistence and environmental safety.
Social entrepreneurs as institutional entrepreneurs: evidence from a comparative case study
Authors: Chatzichristos Georgios , Nagopoulos Nikolaos 
Published: June 2021

PurposeThis study aims to illuminate the field conditions under which social entrepreneurship can become institutionalized and transform the existing institutional fields.Design/methodology/approachA comparative case study was conducted among three social enterprises, within different regional institutional fields, following a most different systems design: OTELO, in Mühlviertel, ADC MOURA, in Baixo Alentejo and STEVIA HELLAS in Phthiotis.FindingsThe results indicate some of the field conditions under which an institutionalization of social entrepreneurship can thrive, namely, a high civil approval, a highly institutionalized and decentralized institutional field that allows the social enterprise to remain autonomous, as well the anchoring of the venture to a pre-existing counter-hegemonic narrative or/and to an embedded network that drives the dissemination a new institutional logic forward.Research limitations/implicationsThe institutionalization of the voluntary collective action that social entrepreneurship embodies has significant limitations. The same is true for innovation, which tends to lose its innovative spirit as it becomes institutionalized. Future research has to explore if institutionalized social entrepreneurship can maintain a voluntary perspective and an innovative drift.Originality/valueMost studies on institutional entrepreneurship deploy in-depth case studies while multi-case comparative research remains rare. The current comparative study adds significantly to the understanding of institutional entrepreneurship, as it compares different degrees of institutionalization and successful institutional entrepreneurs to non-successful ones.
Air-travel services industry in the post-COVID-19: the GPS (Guard-Potentiate-Shape) model for crisis navigation
Authors: Bodolica Virginia , Spraggon Martin , Khaddage-Soboh Nada 
Published: June 2021

Purpose
Extant crisis response literature focuses on the survival and adaptation efforts of organizations, leaving the opportunity of deploying more proactive market-shaping strategies unexplored. This paper aims to examine the early strategic responses deployed by air-travel services players for navigating through the COVID-19 pandemic.

Design/methodology/approach
Drawing on a qualitative case study and grounded theory methods, this research analyzes how DUBZ – a purposefully selected company operating in the air-travel services sector in the emirate of Dubai (UAE) – responded to the coronavirus disruption.

Findings
Using this unique case as a basis for grounded theorizing, a framework was developed for understanding how air-travel service providers can effectively navigate through the crisis – the guard-potentiate-shape model. The advanced model suggests that in times of disruption, industry players should adopt several strategies to: guard against failure; potentiate innovative change; and shape the future design of air-travel services. An outcome of forward-looking shaping strategies that may define the new post-pandemic normal in the air-travel services sector constitutes the idea of “scattered/diffused airports” with a modified design of airport services architecture.

Originality/value
The insights from the grounded theoretical framework contribute to both the empirical research on crisis management and the nascent literature on market-shaping strategies. Air-travel services organizations may learn how to increase their resilience and build new industry normalcy in the post-disruption period.
Genome‐wide DNA methylation and transcription analysis in tongue and biceps femoris muscles of cloned pigs with macroglossia
Authors: Yang Q. , Qiao C. M. , Liu W. W. , Jiang H. Y. , Jing Q. Q. , Liao Y. Y. , Xing Y. Y. 
Published: June 2021

SummaryCloned animals are prone to abnormal phenotypes such as enlarged tongue, fetal oversize, and progeria. In the present study, whole‐genome bisulfite sequencing and mRNA sequencing were performed on tongue and biceps femoris muscles of cloned piglets with and without macroglossia, in an attempt to elucidate the epigenetic causes of the macroglossia phenotype. We identified 14 958 and 18 752 differentially methylated regions in the tongue and biceps femoris muscles, respectively, of macroglossia piglets and these correspond to 4574 and 4772 differentially methylated genes compared with the control group (piglets without macroglossia). Larger methylation difference was found in tongue muscle than in biceps femoris muscle. In total, 114 genes in tongue and 72 genes in biceps femoris muscles were found to be differentially expressed between the two groups. Of these differentially expressed genes in tongue muscle, 31 were also differentially methylated genes, among which DIO3 and ZIC1 were imprinting or predicted imprinting genes. These two and another six overlapping genes (ALDH1A2, MKX, MAB21L2, CA3, RANBP3L, and MYL10) are crucial factors involved in embryonic development or tissue and organ development. GO enrichment analysis suggested possible alteration of these processes. Our study provides novel molecular insights into the formation of macroglossia in cloned pigs.
A further survey of the quantitative trait loci affecting swine body size and carcass traits in five related pig populations
Authors: Li L.‐y. , Xiao S.‐j. , Tu J.‐m. , Zhang Z.‐k. , Zheng H. , Huang L.‐b. , Huang Z.‐y. , Yan M. , Liu X.‐d. , Guo Y.‐m. 
Published: June 2021

SummaryBreeding for good meat quality performance while maintaining large body size and desirable carcass traits has been the major challenge for modern swine selective breeding. To address this goal, in the present work we studied five related populations produced by two commercial breeds (Berkshire and Duroc) and two Chinese breeds (Licha black pig and Lulai black pig). A single‐trait GWAS performed on 20 body size and carcass traits using a self‐developed China Chip‐1 porcine SNP50K BeadChip identified 11 genome‐wide significant QTL on nine chromosomes and 22 suggestive QTL on 15 chromosomes. For the 11 genome‐wide significant QTL, eight were detected in at least two populations, and the rest were population‐specific and only mapped in Shanxia black pig. Most of the genome‐wide significant QTL were pleiotropic; for example, the QTL around 75.65 Mb on SSC4 was associated with four traits at genome‐wide significance level. After screening the genes within 50 kb of the top SNP for each genome‐wide significant QTL, NR6A1 and VRTN were chosen as candidate genes for vertebrae number; PLAG1 and BMP2 were identified as candidate genes for body size; and MC4R was the strong candidate gene for body weight. The four genes have been reported as candidates for thoracic vertebrae number, lumbar vertebrae number, carcass length and body weight respectively in previous studies. The effects of VRTN on thoracic vertebrae number, carcass length and body length have been verified in Shanxia black pig. Therefore, the VRTN genotype could be used in gene‐assisted selection, and this could accelerate genetic improvement of body size and carcass traits in Shanxia black pig.
Learning curve for laparoscopic cholecystectomy has not been defined: A systematic review
Authors: Reitano Elisa , de'Angelis Nicola , Schembari Elena , Carrà Maria Clotilde , Francone Elisa , Gentilli Sergio , La Greca Gaetano 
Published: June 2021

AbstractBackgroundLaparoscopic cholecystectomy is one of the most performed surgeries worldwide but its learning curve is still unclear.MethodsA systematic review was conducted according to the 2009 Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines. Two independent reviewers searched the literature in a systematic manner through online databases, including Medline, Scopus, Embase, and Google Scholar. Human studies investigating the learning curve of laparoscopic cholecystectomy were included. The Newcastle–Ottawa scale for cohort studies and the GRADE scale were used for the quality assessment of the selected articles.ResultsNine cohort studies published between 1991 and 2020 were included. All studies showed a great heterogeneity among the considered variables. Seven articles (77.7%) assessed intraoperative variables only, without considering patient's characteristics, operator's experience, and grade of gallbladder inflammation. Only five articles (55%) provided a precise cut‐off value to see proficiency in the learning curve, ranging from 13 to 200 laparoscopic cholecystectomies.ConclusionsThe lack of clear guidelines when evaluating the learning curve in surgery, probably contributed to the divergent data and heterogeneous results among the studies. The development of guidelines for the investigation and reporting of a surgical learning curve would be helpful to obtain more objective and reliable data especially for common operation such as laparoscopic cholecystectomy.
Novel impedance‐pH parameters are associated with proton pump inhibitor response in patients with inconclusive diagnosis of gastro‐oesophageal reflux disease according to Lyon Consensus
Authors: Ribolsi Mentore , Frazzoni Marzio , Marabotto Elisa , De Carlo Giovanni , Ziola Sebastiano , Maniero Daria , Balestrieri Paola , Cicala Michele , Savarino Edoardo 
Published: June 2021

SummaryBackgroundThe Lyon Consensus delineates impedance‐pH parameters that can demonstrate/exclude gastro‐oesophageal reflux disease (GERD). In patients with acid exposure time between 4% and 6%, GERD diagnosis has been considered inconclusive. In these cases, mean nocturnal baseline impedance (MNBI) and post‐reflux swallow‐induced peristaltic wave (PSPW) index may either confirm or refute GERD diagnosis and represent predictors of proton pump inhibitor (PPI) response.AimsTo investigate the diagnostic yield of MNBI and PSPW index and their relationship with PPI response in patients with inconclusive GERD diagnosis.MethodsReview of impedance‐pH tracings from PPI responder/non‐responder patients with typical reflux symptoms. Multivariate regression analysis was performed to determine the association of MNBI and PSPW index to PPI response.ResultsAmong 233 patients evaluated, 145/233 (62.2%) were PPI responders; 62 had conclusive and 65 inconclusive evidence of GERD, 46 had reflux hypersensitivity, and 60 functional heartburn. Abnormal MNBI and PSPW index were significantly more frequent in inconclusive GERD as compared to the functional heartburn group (P < 0.001). Within the inconclusive GERD group, 35/65 (54%) patients were PPI responders and displayed a significantly higher proportion of cases with pathological MNBI or PSPW index as compared to non‐responders (32/35 [91.4%] and 30/35 [85.7%] vs 9/30 [30%] and 7/30 [23.3%], P < 0.001). By multivariate analysis, pathological PSPW index and/or MNBI values were significantly associated with PPI response in all groups.ConclusionsThe present study highlights the value of MNBI and PSPW index as adjunctive metrics in characterising patients with inconclusive evidence of GERD and identifying those responsive to PPI treatment.
A formalized approach to choosing the best methods for reconstructing stature in the case of poorly preserved skeletal series
Authors: Mahler Robert 
Published: June 2021

AbstractStature, as the universal measure of the well‐being of a population, is one of the three basic characteristics, besides sex and age, of every osteological analysis. Reconstructing living stature using the length of long bones and linear regression is the method of choice, especially in the case of poorly preserved human skeletal material obtained from archaeological excavations. Although the choice of the best formulae is usually based on intuition, the need for a more formal approach is paramount. However, the solutions adopted to date require a significant number of well‐preserved skeletons, which is rarely possible in bioarchaeological research.For skeletal series consisting of very incomplete skeletons, it has been shown that a simple comparison of the mean differences in stature estimation using femur, humerus, and radius bone pairs may be instrumental for selecting the most appropriate of the available stature reconstruction methods. The results were confronted with the consistency of the same methods but also using bones that could not have been used previously; that is the tibia, fibula and ulna. All the methods tested were then compared with those selected as being the most consistent to see if the results they produce are significantly different.
Current knowledge, challenges and innovations in developmental pharmacology: A combined conect4children Expert Group and European Society for Developmental, Perinatal and Paediatric Pharmacology White Paper
Authors: Smits Anne , Annaert Pieter , Cavallaro Giacomo , De Cock Pieter A. J. G. , de Wildt Saskia N. , Kindblom Jenny M. , Lagler Florian B. , Moreno Carmen , Pokorna Paula , Schreuder Michiel F. , Standing Joseph F. , Turner Mark A. , Vitiello Benedetto , Zhao Wei , Weingberg Annelie‐Martina , Willmann Raffaella , van den Anker John , Allegaert Karel 
Published: June 2021

Developmental pharmacology describes the impact of maturation on drug disposition (pharmacokinetics, PK) and drug effects (pharmacodynamics, PD) throughout the paediatric age range. This paper, written by a multidisciplinary group of experts, summarizes current knowledge, and provides suggestions to pharmaceutical companies, regulatory agencies and academicians on how to incorporate the latest knowledge regarding developmental pharmacology and innovative techniques into neonatal and paediatric drug development.Biological aspects of drug absorption, distribution, metabolism and excretion throughout development are summarized. Although this area made enormous progress during the last two decades, remaining knowledge gaps were identified. Minimal risk and burden designs allow for optimally informative but minimally invasive PK sampling, while concomitant profiling of drug metabolites may provide additional insight in the unique PK behaviour in children. Furthermore, developmental PD needs to be considered during drug development, which is illustrated by disease‐ and/or target organ‐specific examples. Identifying and testing PD targets and effects in special populations, and application of age‐ and/or population‐specific assessment tools are discussed. Drug development plans also need to incorporate innovative techniques such as preclinical models to study therapeutic strategies, and shift from sequential enrolment of subgroups, to more rational designs.To stimulate appropriate research plans, illustrations of specific PK/PD‐related as well as drug safety‐related challenges during drug development are provided. The suggestions made in this joint paper of the Innovative Medicines Initiative conect4children Expert group on Developmental Pharmacology and the European Society for Developmental, Perinatal and Paediatric Pharmacology, should facilitate all those involved in drug development.
Thymopentin alleviates premature ovarian failure in mice by activating YY2/Lin28A and inhibiting the expression of let‐7 family microRNAs
Authors: Liu Te , Jing Fangyuan , Huang Peirong , Geng Zixiang , Xu Jianghong , Li Jiahui , Chen Danping , Zhu Ying , Wang Zhenxin , Huang Willian , Chen Chuan 
Published: June 2021

AbstractObjectiveThymopentin (5TP) significantly improved typical murine premature ovarian failure (POF) symptoms induced by a high‐fat and high‐sugar (HFHS) diet. However, its effect and mechanism remain unclear.Materials and methodsRNA‐Seq was used to detect the differentially expressed genes among each group. HFHS‐induced POF mouse model was generated and injected with siRNA using Poly (lactic‐co‐glycolic acid) (PLGA) as a carrier.ResultsRNA‐Seq suggested that 5TP promoted the expression of Yin Yang 2 (YY2) in mouse ovarian granulosa cell (mOGC) of HFHS‐POF mice. Luciferase reporter assay indicated that 5TP promoted the binding of YY2 to the specific sequence C(C/T)AT(G/C)(G/T) on the Lin28A promoter and promoted Lin28A transcription and expression. We continuously injected PLGA‐cross‐linked siRNA nanoparticles targeting YY2 into HFHS‐POF mice (siYY2@PLGA), which significantly reduced the therapeutic effect of 5TP. siYY2@PLGA injection also significantly attenuated the upregulation of Lin28a expression in mOGCs induced by 5TP and enhanced the expression of let‐7 family microRNAs, thereby inhibiting the proliferation and division of mOGCs. qPCR results showed that there was a significant difference in the expression levels of exosome‐derived Yy2 mRNAs between POF patients and normal women, and that there was a specific correlation between the expression level of exosome‐derived Yy2 and the peripheral concentrations of the blood hormones pregnenolone, progesterone and oestradiol.ConclusionsThymopentin promotes the transcriptional activation of Lin28A via stimulating transcription factor YY2 expression, inhibits the activity of let‐7 family microRNAs and alleviates the ageing of ovarian granulosa cells, ultimately achieving a therapeutic effect on POF in mice.
A European eel (Anguilla anguilla) case study using structured elicitation to estimate instream infrastructure passability for freshwater fishes
Authors: Thomas Merryn J. , Pawar Sayali K. , Januchowski‐Hartley Stephanie R. 
Published: June 2021

AbstractConservation efforts are hampered by limited understanding about how different types of instream infrastructure impact migration patterns and fish survival. We used a rapid, fully online IDEA protocol to elicit expert judgments for the passability of seven different in‐stream infrastructures to elver European eels (Anguilla anguilla) in Great Britain. Nine experts provided judgments via our online survey, followed by a second elicitation via email for reflection and adjustment of initial estimates. We found that on average, bridges were judged the most passable (95% passability), followed by fords, nonperched culverts, weirs, sluices, dams, and perched culverts (7%). Results showed a high degree of agreement about how passable bridges and perched culverts are for elver eels, but less certainty about other infrastructure. Thirty‐four distinct factors were identified that experts believed influence infrastructure passability for elver eels, including: the structure itself, hydraulics, elver characteristics, obstructions (e.g., debris accumulation), and vegetation (e.g., to aid climbing). We discuss how our rapid, online‐only variation on the IDEA protocol compares with the more traditional protocol, and how the expert estimates generated in this study can be used in future scenario building and connectivity modeling, with a view to improving conservation to support species persistence.
Sentiment analysis for Urdu online reviews using deep learning models
Authors: Safder Iqra , Mahmood Zainab , Sarwar Raheem , Hassan Saeed‐Ul , Zaman Farooq , Nawab Rao Muhammad Adeel , Bukhari Faisal , Abbasi Rabeeh Ayaz , Alelyani Salem , Aljohani Naif Radi , Nawaz Raheel 
Published: June 2021

AbstractMost existing studies are focused on popular languages like English, Spanish, Chinese, Japanese, and others, however, limited attention has been paid to Urdu despite having more than 60 million native speakers. In this paper, we develop a deep learning model for the sentiments expressed in this under‐resourced language. We develop an open‐source corpus of 10,008 reviews from 566 online threads on the topics of sports, food, software, politics, and entertainment. The objectives of this work are bi‐fold (a) the creation of a human‐annotated corpus for the research of sentiment analysis in Urdu; and (b) measurement of up‐to‐date model performance using a corpus. For their assessment, we performed binary and ternary classification studies utilizing another model, namely long short‐term memory (LSTM), recurrent convolutional neural network (RCNN) Rule‐Based, N‐gram, support vector machine , convolutional neural network, and LSTM. The RCNN model surpasses standard models with 84.98% accuracy for binary classification and 68.56% accuracy for ternary classification. To facilitate other researchers working in the same domain, we have open‐sourced the corpus and code developed for this research.
Production of dallisgrass in response to NPK fertilizer in southwest China and its implications for cultivation
Authors: Wang Leiting , Ding Leilei , Wang Puchang , Zhao Lili , Yu Qingqing 
Published: June 2021

AbstractDallisgrass (Paspalum dilatatum Poir.), a warm‐season forage, is a perennial grass with high nutritional value, good palatability and high‐stress resistance in subtropical regions worldwide. However, very limited information is available on the cultivation of dallisgrass, especially in southwest China. Soils in different areas with pasture cultivation histories were collected and mixed evenly as substrate soil. Pot experiments after fertilization with nitrogen (N), phosphorus (P) and potassium (K) are used to analyze the dallisgrass growth characteristics, dry matter biomass (DM), photosynthetic characteristics, nutrient accumulation, agronomic efficiency (AE), partial factor productivity (PFP) and recovery efficiency (RE). A three‐factor (N, P, K) and five‐level (N: 0, 48.66, 120, 191.34 and 240 kg/ha; P: 0, 68.93, 170, 271.07 and 340 kg/ha; K: 0, 30.41, 75, 119.59 and 150 kg/ha) quadratic regression orthogonal rotation combination design was used with three experimental plots per management strategy for multiple comparisons within each harvest. Compared with no fertilization, the optimal treatment (OPT, N 48.66 kg/ha, P 68.93 kg/ha, K 119.59 kg/ha) increased yield by 46.3%, but the effect of NPK alone was not significant. This is because OPT improves the morphology and photosynthetic characteristics of dallisgrass, cause the dry matter during the growth period is significantly (p < .05) increased, and the average nutrient use efficiency (7.45%) under the OPT management measures was much higher than the under N, P and K fertilization alone (approximately 2.61 times). More meaningfully, we found that the demand for P and K fertilizer in dallisgrass in a typical subtropical mountainous region of China is higher than that for N. Overall, these findings have important implications for the cultivation of dallisgrass.