bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of capital investment, investment risks, and globalization in economic growth
Authors: Sun Chunxia , Abbas Hafiz Syed Mohsin , Xu Xiaodong , Gillani Samreen , Ullah Saif , Raza Muhammad Ahsan Ali 
Published: February 2021

AbstractThe study investigates the role of public and private capital investment and globalization in the economic growth of 34 Asian economies along with investment risk and demographic pressure. By applying the two‐step system generalized method of moment, results show that private capital investment in Asian emerging‐economies has been a substantial positive impact on regional economic growth and is significantly influenced by low‐investment risks and demographic conditions as compared to low‐income and advance‐economies from 2001 to 2019. It further states that economic globalization accelerates the economic growth in Asian emerging, developing, and low‐income economies compared to advanced‐economies. This study contributes to the existing literature by analyzing Asian economies in two ways (separately public and private investment and economic globalization index to economic growth), which has been scarce in this regard. The study also suggests that private capital investment should be backed with low‐risk investment policies that create more private investment, enhance the institutional capacity, productivity, and attract foreign investors. This study's findings highlight that, for the development of the economies, private‐investment inclusion with public‐investment is the backbone that can accelerate economic growth by controlling external pressures and business risk in the country with effective public policies.
Determinants and hedging effectiveness of China's sovereign credit default swaps
Authors: Muvunza Taurai , Jiang Yong 
Published: February 2021

AbstractIn this study, we examine determinants and hedging effectiveness of China's sovereign credit default swaps (CDS) spread from January 2010 to April 2020. While both domestic and global factors are important variables that explain China's CDS in changes and levels, we find that global variables have more explanatory power compared to China's domestic economic factors. Analysis of Markov regime‐switching results demonstrate that MSCI Asia is a good indicator for China's CDS spread during tranquil state while gold is a more relevant predictor in the turbulent state. Our results further indicate that domestic variables determine China's CDS spread better than global variables during crisis period. Using dynamic conditional correlation (DCC) GARCH model, we show that China's CDS are a strong hedge and effective diversifier for domestic and international stock market indexes.
Stock market reaction to macroeconomic variables: An assessment with dynamic autoregressive distributed lag simulations
Authors: Khan Muhammad Kamran , Teng Jian‐Zhou , Khan Muhammad Imran , Khan Muhammad Fayaz 
Published: February 2021

AbstractThis research investigates the impact of oil prices, gold prices and exchange rate on Shanghai stock exchange returns. In this study, we used monthly time series data from January 2000 to December 2018. The dynamic autoregressive distributed lag simulations model proposed by Jordan and Philips is used to examine the real change in regressors and their impact on regressand by using graphical representations. The examined results of the dynamic simulated autoregressive distributed lag model indicate that oil prices and gold prices have a positive effect on the stock returns in the short run and in the long run while the exchange rate indicate negative effect both in the short run and in the long run. Our research findings have significant implications for policymakers.
Predictors of cerclage failure in singleton pregnancies with a history of preterm birth and a sonographic short cervix
Authors: Pan Mian , Fang Jiao‐Ning , Wang Xiao‐Xiao , Zhang Jun , Lin Zhi 
Published: February 2021

AbstractObjectiveTo identify predictors of ultrasound‐indicated cerclage failure in singleton pregnancies for preventing extremely preterm birth.MethodsA retrospective cohort study included 96 singleton pregnancies with ultrasound‐indicated McDonald cerclage in women with previous preterm birth (PTB) and cervical shortening. Descriptive statistics were calculated at baseline and logistic regression analyses were performed to identify the factors associated with cerclage failure.ResultsIn all, 28 (29%) of the women had a preterm delivery at before 28 weeks. Multivariate analysis identified cervical dilatation, non‐cephalic presentation, and platelet‐lymphocyte ratio (PLR) as independent predictors of cerclage failure (odds ratio [OR] 3.12, 95% CI [confidence interval] 1.01–9.66; OR 5.81, 95% CI 1.04–32.53; OR 1.02, 95% CI 1.01–1.03, respectively). The efficacy of these predictors was evaluated using a receiver operating characteristics curve. The area under the curve was 0.87 (95% CI 0.78–0.96, P < 0.001) with a sensitivity of 78.6% and specificity of 88.2%.ConclusionOur findings indicated that cervical dilatation, fetal presentation, and PLR were valuable predictors of cerclage failure in singleton pregnancies with a history of PTB and a sonographic short cervix. The results can be potentially used to assess the prognosis of patients after cerclage and alert clinicians to consider enhanced surveillance and administration of individuals at an increased risk.
Data Governance 101: IR's Critical Role in Data Governance
Authors: Hubbard Dan , Freda Augie , Swanagan Andrea 
Published: February 2021

AbstractBuilding a culture of data governance at a higher education institution involves collaboration across the entire institution. Before the creation of formalized roles to perform data management and data governance functions at colleges and universities, these functions were performed by traditional institutional research personnel. Documentation and management of data for analysis have, for a long time, been part of the institutional researcher's forte. However, a concentrated effort in data management and governance is necessary to transform traditional reporting into a dynamic analytic landscape complete with adequate definitions and documentation, and often this goes beyond the scope of today's institutional research offices. The following article offers a framework for developing a data governance program in a higher education setting and highlights the critical role that institutional research offices can play in helping to build institutional capacity for a well‐documented and managed data landscape. Support and rationale for developing a program at your institution are offered, and helpful tips and pitfalls to avoid are provided.
Genomic markers confirm introgressive hybridization in Cichla (Teleostei) in an invaded coastal system
Authors: Diamante Nathália A. , de Oliveira Alessandra V. , Petry Ana C. , Catelani Paula A. , Pelicice Fernando M. , Mueller Larissa P. , Prioli Sônia M. A. P. , Prioli Alberto J. 
Published: February 2021

AbstractHybridization seems frequent among Cichla species (peacock bass), as studies have reported hybrids in populations within and outside their natural range (the Amazon and Orinoco river basins). Cichla kelberi and C. monoculus were introduced to the São João river (Southeast Brazil) more than 20 years ago, where they successfully colonized different environments. In this system, specimens have coloration and morphology that differ from patterns observed in their native range, indicating that the contact between C. monoculus and C. kelberi eliminated reproductive isolation, leading to introgressive hybridization. In this context, we used the LWS and dlx2 genes and the random amplified polymorphic DNA technique to characterize Cichla species in the São João river and to detect possible hybridization processes. The genetic markers identified here showed mismatches between mitochondrial and nuclear DNA in C. monoculus and C. kelberi, sampled both in the reservoir and in the estuarine stretch. Fragments of nuclear DNA from both species, as well as the presence of mitochondrial DNA from one species associated with the nuclear genome of the other, provide strong evidence of hybridization associated with bidirectional genetic introgression. Because hybrids may be more resistant, competitive, and aggressive than their parental species, these invaders may pose a significant threat to native biodiversity in this and other coastal rivers of the region.
Substratum selection and feeding responses influence the demography of the sessile rotifer Cupelopagis vorax (Collothecacea: Atrochidae)
Authors: Espinosa‐Rodríguez Cristian Alberto , Sarma S. S. S. , Sarma Nandini , Wallace Robert L. 
Published: February 2021

AbstractLarvae of the sessile rotifer Cupelopagis vorax swim using their ciliated corona, but do not feed. Once they attach to a substratum and metamorphose into adults, they are predatory on protozoans and micrometazoans. Here we present information on ingestion time, feeding behaviour and food preference of C. vorax using protozoans and non‐sessile rotifers as prey. We also tested effects of physical, chemical and biological stimuli on settlement of C. vorax larvae and, using life table experiments, determined their survivorship and fecundity on three, free‐floating macrophytes. Ingestion time was shortest on prey species smaller than 100 µm. Capture/attack ratio was low for Brachionus calyciflorus, but high for Lecane inermis and Peranema sp. The ingestion/capture ratio was lowest for Oxytricha sp. and highest for Euchlanis lyra and Squatinella lamellaris. Species that swim slowly and close to the surface of hydrophytes (E. lyra, Lepadella patella, L. inermis, Peranema sp., Philodina sp. and S. lamellaris) had lower ingestion time, higher encounter/attack ratio, and were the preferred prey in selectivity experiments. Larval settlement was higher on macrophyte leaves of Ceratophyllum demersum, Lemna valdiviana and Wolffiella sp., but lower on Azolla filiculoides and Wolffia columbiana. Coverslips coated with dried extracts of macrophytes showed lower rates of larval settlement compared to live macrophytes, as well as coverslips that had been allowed to develop natural biofilms or were physically roughened. Contrary to what might be expected from the settling tests, life‐table experiments showed that W. columbiana enhanced survivorship (mean lifespan and life expectancy) and rate of population increase, while animals attached to Wolffiella sp. had lower values for life history characteristics. This study adds to our understanding of the impact of Cupelopagis predation on protozoans and rotifers and the importance of substratum selection on larval settlement, adult survival, and reproductive potential after larval settlement.
Time‐varying income elasticities of healthcare expenditure for the OECD and Eurozone
Authors: Casas Isabel , Gao Jiti , Peng Bin , Xie Shangyu 
Published: February 2021

SummaryWe propose a panel data model for nonstationary variables with interactive fixed effects and coefficients that may vary over time and use it to examine time variation in the income elasticity of health expenditures in the OECD and the Eurozone. Our empirical analysis shows that the income elasticity of healthcare expenditure slightly increased in the OECD and the Eurozone during 1995–2004 but remained below one. This finding suggests that healthcare is not a luxury good in these countries.
Functional Scaffold-Free Bone Equivalents Induce Osteogenic and Angiogenic Processes in a Human In Vitro Fracture Hematoma Model
Authors: Pfeiffenberger Moritz , Damerau Alexandra , Ponomarev Igor , Bucher Christian H , Chen Yuling , Barnewitz Dirk , Thöne-Reineke Christa , Hoff Paula , Buttgereit Frank , Gaber Timo , Lang Annemarie 
Published: February 2021

ABSTRACT
After trauma, the formed fracture hematoma within the fracture gap contains all the important components (immune/stem cells, mediators) to initiate bone regeneration immediately. Thus, it is of great importance but also the most susceptible to negative influences. To study the interaction between bone and immune cells within the fracture gap, up-to-date in vitro systems should be capable of recapitulating cellular and humoral interactions and the physicochemical microenvironment (eg, hypoxia). Here, we first developed and characterized scaffold-free bone-like constructs (SFBCs), which were produced from bone marrow–derived mesenchymal stromal cells (MSCs) using a macroscale mesenchymal condensation approach. SFBCs revealed permeating mineralization characterized by increased bone volume (μCT, histology) and expression of osteogenic markers (RUNX2, SPP1, RANKL). Fracture hematoma (FH) models, consisting of human peripheral blood (immune cells) mixed with MSCs, were co-cultivated with SFBCs under hypoxic conditions. As a result, FH models revealed an increased expression of osteogenic (RUNX2, SPP1), angiogenic (MMP2, VEGF), HIF-related (LDHA, PGK1), and inflammatory (IL6, IL8) markers after 12 and 48 hours co-cultivation. Osteogenic and angiogenic gene expression of the FH indicate the osteoinductive potential and, thus, the biological functionality of the SFBCs. IL-6, IL-8, GM-CSF, and MIP-1β were detectable within the supernatant after 24 and 48 hours of co-cultivation. To confirm the responsiveness of our model to modifying substances (eg, therapeutics), we used deferoxamine (DFO), which is well known to induce a cellular hypoxic adaptation response. Indeed, DFO particularly increased hypoxia-adaptive, osteogenic, and angiogenic processes within the FH models but had little effect on the SFBCs, indicating different response dynamics within the co-cultivation system. Therefore, based on our data, we have successfully modeled processes within the initial fracture healing phase in vitro and concluded that the cross-talk between bone and immune cells in the initial fracture healing phase is of particular importance for preclinical studies. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Critical role of miR‐26a‐5p/Wnt5a signaling in gambogic acid‐induced inhibition of gastric cancer
Authors: Zhang Zhixin , Liang Lili , Cao Gang 
Published: February 2021

AbstractGastric cancer (GC) represents the fifth most human malignant disease and the third‐most common cause of cancer‐related death. Gambogic acid (GA) is a natural compound with a polyprenylated xanthone structure and possesses remarkable antitumor activity in a variety of cancer cells. However, the mechanism underlying the inhibitory effect of GA in GC is far from being completely understood. The goal of the present study is to investigate whether potential microRNAs are involved in antitumor effect of GA toward GC and to elucidate the possible mechanisms. We identified that miR‐26a‐5p was significantly increased by GA in GC cell lines and xenograft tumor. Downregulation of miR‐26a‐5p not only prevented GA‐induced inhibition on GC cell growth, but also suppressed GA‐induced apoptosis of GC cells. Informatics assay predicted that Wnt5a was regulated by miR‐26a‐5p and GA‐induced downregulation of Wnt5a was prevented by anti‐miR‐26a‐5p. Reporter gene assay showed that miR‐26a‐5p could negatively regulate Wnt5a through direct binding with 3ʹ‐UTR messenger RNA of Wnt5a. Thus, upregulation of Wnt5a exhibited the same action tendency for GA‐induced GC cell growth and apoptosis as observed by downregulation of miR‐26a‐5p. In conclusion, these results indicated that the inhibitory effect of GA on GC was mediated by the upregulation of miR‐26a‐5p and downregulation of Wnt5a. Our study provided new clues for the potential therapeutic effect of GA against GC and highlighted the importance of miR‐26a‐5p/Wnt5a pathway in the regulation of GC development.
A comprehensive evaluation of skin aging‐related circular RNA expression profiles
Authors: Wang Lili , Si Xijian , Chen Shuang , Wang Xiuli , Yang Dan , Yang Henan , He Chundi 
Published: February 2021

ABSTRACTBackgroundCircular RNAs (circRNAs) have been shown to play important regulatory roles in a range of both pathological and physiological contexts, but their functions in the context of skin aging remain to be clarified. In the present study, we therefore, profiled circRNA expression profiles in four pairs of aged and non‐aged skin samples to identify identifying differentially expressed circRNAs that may offer clinical value as biomarkers of the skin aging process.MethodsWe utilized an RNA‐seq to profile the levels of circRNAs in eyelid tissue samples, with qRT‐PCR being used to confirm these RNA‐seq results, and with bioinformatics approaches being used to predict downstream target miRNAs for differentially expressed circRNAs.ResultsIn total, we identified 571 circRNAs with 348 and 223 circRNAs being up and downregulated that were differentially expressed in aged skin samples compared to young skin samples. The top 10 upregulated circRNAs in aged skin sample were hsa_circ_0123543, hsa_circ_0057742, hsa_circ_0088179, hsa_circ_0132428, hsa_circ_0094423, hsa_circ_0008166, hsa_circ_0138184, hsa_circ_0135743, hsa_circ_0114119, and hsa_circ_0131421. The top 10 reduced circRNAs were hsa_circ_0101479, hsa_circ_0003650, hsa_circ_0004249, hsa_circ_0030345, hsa_circ_0047367, hsa_circ_0055629, hsa_circ_0062955, hsa_circ_0005305, hsa_circ_0001627, and hsa_circ_0008531. Functional enrichment analyses revealed the potential functionality of these differentially expressed circRNAs. The top 3 enriched gene ontology (GO) terms of the host genes of differentially expressed circRNAs are regulation of GTPase activity, positive regulation of GTPase activity and autophagy. The top 3 enriched KEGG pathway ID are Lysine degradation, Fatty acid degradation and Inositol phosphate metabolism. The top 3 enriched reactome pathway ID are RAB GEFs exchange GTP for GDP on RABs, Regulation of TP53 Degradation and Regulation of TP53 Expression and Degradation. Six circRNAs were selected for qRT‐PCR verification, of which 5 verification results were consistent with the sequencing results. Moreover, targeted miRNAs, such as hsa‐miR‐588, hsa‐miR‐612, hsa‐miR‐4487, hsa‐miR‐149‐5p, hsa‐miR‐494‐5p were predicted for circRna‐miRna interaction networks.ConclusionOverall, these results offer new insights into circRNA expression profiles, potentially highlighting future avenues for research regarding the roles of these circRNAs in the context of skin aging.
Group schema therapy for patients with cluster‐C personality disorders: A case study on avoidant personality disorder
Authors: Bachrach Nathan , Arntz Arnoud 
Published: February 2021

AbstractThis article presents a clinical illustration of group schema therapy (GST) for cluster‐C personality disorders (CL‐C PDs) to provide therapists an example on how one can perform GST for CL‐C PDs and break through persistent avoidance and control mechanisms. A summary of evidence supporting the effectiveness of GST for CL‐C PD's is given followed by an overview of basic principles of schema therapy and GST. A case presentation next illustrates the application of GST principles and interventions in the GST CL‐C protocol, which improve clients understanding of emotional core needs and development of adaptive ways of getting needs better met, instead of avoiding life. Implications of the case for future applications of GST for CL‐C PDs are discussed.
Comparison and interaction of morphine and CB1 agonist conditioned place preference in the rat model of early life stress
Authors: Pirri Fardad , Akbarabadi Ardeshir , Sadat‐Shirazi Mitra‐Sadat , Nouri Zadeh‐Tehrani Setareh , Mahboubi Sarah , Karimi Goudarzi Ali , Zarrindast Mohammad‐Reza 
Published: February 2021

AbstractEarly life stress (ELS) disrupts brain development and subsequently affects physical and psychological health. ELS has been associated with an increased risk of relapse and inadequate treatment response in addicted patients. The current study was designed to find the effect of ELS on the rewarding effect of morphine and cannabinoid and their interaction. Pregnant female Wistar rats were used in this study. On postnatal day 2 (PND2), pups were separated from their mothers for 3 hr daily. This procedure was repeated every day at the same time until PND 14. The control group was kept in the standard nesting way with their mothers. The adult male offspring of maternal separated (MS) and standard nested (SN) rats were used. Using conditioned place preference task (CPP), the rewarding effect of morphine (0.75, 1.25, 2.5, and 5 mg/kg) was evaluated in both MS and SN groups. Besides, the rewarding effect of cannabinoids was investigated using the administration of CB1 receptor agonist (ACPA, 0.25, 0.5, 1 µg/rat) and inverse agonist (AM‐251, 30, 60, and 90 ng/rat) in the nucleus accumbens (NAc). To evaluate the interaction between NAc cannabinoidergic system and morphine, the noneffective dose of ACPA and AM‐251 were administered with a noneffective dose of morphine (0.75 mg/kg) on both MS and SN animals. Obtained results indicated that MS groups had a leftward shift in the rewarding effect of morphine and conditioned with low doses of morphine. However, they had a rightward shift in the rewarding effect of cannabinoids. In addition, coadministration of noneffective doses of morphine and ACPA potentiate conditioning in both MS and SN groups. Previous evidence shows that ELS induced changes in the brain, especially in the reward circuits. Here, we demonstrated that MS animals are more sensitive to the rewarding effect of morphine compared with SN animals. In addition, ELS disrupts the cannabinoid system and affect the rewarding effect of cannabinoids.
Idiopathic multitudinous fundic gland polyposis: A new disease and a management dilemma
Authors: Lam Shiu Kum , Lau George K K 
Published: February 2021

AbstractTwo patients with idiopathic multitudinous fundic gland polyposis, a hitherto undescribed condition, were reported. They presented incidentally with a multitude of fundic gland polyps, 52 and 147, without a family history of polyposis, and these polyps were not attributable to the chronic use of proton pump inhibitors. All polyps were removed by hot‐biopsy polypectomy, and each was individually subjected to pathological examination, which showed no evidence of dysplasia. When confronted with gastric polyps of clinically undetermined origin, endoscopists would, to exclude dysplasia, usually resect all if they are few and sample some and survey the others periodically if they are numerous. The condition reported presents a management dilemma: Because the number of the polyps is such that they are manageable by total polypectomy, should this be carried out, despite the labor intensiveness involved, to exclude dysplasia, and are the polyps a variant of syndromic polyposis and therefore carry a malignant potential and inform the need for periodic surveillance and to investigate the patient's kindred? The frequency of this condition and whether it is truly not associated with dysplasia require further studies.