bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifikasi Kandungan Boraks Pada Bakso Gerobak Di Jl. Paccerakkang Kota Makassar
Authors: Fira Hardianti S  , Arman  , Abd. Gafur  
Published: December 2021

Boraks merupakan senyawa kimia turunan dari logam berat boron (B) dan biasa digunakan sebagai bahan anti jamur, pengawet kayu, dan antiseptik pada kosmetik. Boraks berbentuk kristal berwarna putih yang terjadi dalam suatu deposit hasil proses penguapan hot spring (pancuran air panas) atau danau garam. Tujuan dari penelitian ini adalah Untuk mengetahui identifikasi kandungan zat pengawet berbahaya boraks pada Bakso Gerobak dan Mie Basah di Jl. Paccerakkang Kota Makassar. Jenis penelitian ini adalah penelitian kualitatif, menggunakan rancangan penelitian observasional dengan pendekatan deskriptif. Teknik pengambilan sampel ini adalah purposive random sampling. Sampel pada penelitian ini adalah Bakso dan Mie Basah yang dijual di Jl. Paccerakkang Kota Makassar. Pada pemeriksaan uji labaratorium, peneliti menggunakan kualitatif dengan metode kurkumin. Sampel bakso diambil dari 10 pedagang bakso gerobak dan 10 pedagang mie baik yang menetap maupun berpindah tempat. Hasil penelitian ini menunjukkan bahwa dari 10 sampel Bakso dan 10 sampel Mie Basah yang diuji terdapat 0 sampel yang positif mengandung boraks. Kesimpulannya adalah dari 20 sampel yang diperiksa baik pada bakso maupun mie basah dinyatakan negative tidak mengandung boraks. Sarannya adalah Dinas Kesehatan dan Badan Besar Pengawasan Obat dan Makanan (BPOM) kota Makassar tetap meningkatkan pemantauan dan pengawasan terhadap berbagai bahan panganyang beredar dalam masyarakat.
Farklı Üretim Sistemlerinden Elde Edilen Zeytinyağı Sanayi Yan Ürünlerin Besleme Değerinin Belirlenmesi
Authors: AKBAĞ Hande Işıl , ÇETİNKESTANE Ömer 
Published: December 2021

Bu çalışmada iki ve üç fazlı üretim sistemlerinden elde edilen pirinanın kimyasal bileşimi ve in vitro gaz üretimi ile rumen içi fermentasyon özelliklerinin belirlenmesi amaçlanmıştır. Bu amaç doğrultusunda üç ve iki fazlı zeytinyağı üretim yapan tesislerinden yaş çekirdekli, kuru çekirdekli ve kuru çekirdeksiz pirina örnekleri temin edilmiştir. Çalışmadan elde edilen bulgulara göre pirina örneklerinin kuru madde (KM) içeriklerinin faza ve pirina tipine göre önemli düzeyde değiştiği belirlenmiştir (P≤0.05). Kuru çekirdeksiz pirina örneklerinin, ham protein (HP) içeriği bakımından diğer pirina (KM’de % 5,63) örneklerinden önemli düzeyde daha düşük ortalamaya sahip olduğu bulgulanmıştır (P≤0.05). Kuru çekirdeksiz pirina örneklerinin diğer pirina örneklerinden daha düşük asit çözücülerde çözünmeyen lignin (ADL), kondanse tanen (KT) ve toplam fenolik bileşen (TFB) içeriğine sahip olduğu belirlenmiştir (P≤0.05). Buna karşın kuru çekirdeksiz pirina örneklerinin, diğer pirina örnekleriyle kıyaslandığında 96 saatlik kümülatif gaz üretimleri, organik madde sindirilebilirlikleri (OMS) ve metabolize olabilir enerji (ME) içerikleri bakımından daha yüksek ortalamaya sahip olduğu belirlenmiştir (P≤0.05).
Sonuç olarak kuru çekirdeksiz pirinanın ruminant beslemede kullanılması önerilebilir ancak HP içeriği düşük olduğundan rasyonun proteince desteklenmesi gerekmektedir.
PENGELOLAAN OBJEK WISATA SUNGAI BORO-BORO BERBASIS KEKERABATAN
Authors: Gongsi Natalia , Marhadi Akhmad , Hartini Hartini 
Published: December 2021

Penelitian bertujuan untuk mengetahui pengelolaan objek wisata sungai Boro-Boro dan pengembangan objek wisata sungai Boro-Boro di Desa Boro-Boro Kecamatan RanomeetoKabupaten Konawe Selatan. Teknik penelitian menggunakan metode etnografi. Penelitian ini juga menggunakan teori pengembangan oleh Twelvetrees. Penelitian ini telah mendapatkan data-data sesuai dengan judul, peneliti melakukan peneliti lapangan yang lebih konkrit dengan melakukan wawancara langsung dengan pihak-pihak yang terkait serta data sekunder berupa data profil desa. Hasil penelitian membuktikan bahwa dalam pengelolaan objek wisata sungai Boro-Boro yang berada di Desa Boro-Boro Kecamatan Ranomeeto Kabupaten Konawe Selatan dikelolah oleh enam bersaudara yang tidak lain adalah anak dari pemilik lahan yaitu Bapak Lauto dan mereka juga merupakan ahli waris tanah yang saat dijadikan sebagai tempat objek wisata. Pengelolaannya dari tahun 2018 sampai saat ini masih terbilang sangat minim jika dibandingkan dengan objek wisata yang lain, terlebih lagi dana untuk pembangunan fasilitas hanya berasal dari retribusi para pengunjung. Namun pengembangan objek wisata sungai boro-boro sudah bisa memenuhi kebutuhan para wisatawan hal ini di tandai dengan adanya beberapa gazebo yang berdiri tepat dipinggir sungai, rumah makan, WC, tambak ikan, dan juga terdapat beberapa villa yang tersedia jika para wisatawan yang hendak ingin bermalam atau melakukan kegiatan di objek wisata sungai boro-boro tersebut. Objek wisata ini juga diharapkan mampu untuk meningkatkan perekonomian masyarakat Desa khususnya Desa Boro-boro Kecamatan Ranomeeto Kabupaten Konawe Selatan.
The Effect of Plasma Triglyceride-Lowering Therapy on the Evolution of Organ Function in Early Hypertriglyceridemia-Induced Acute Pancreatitis Patients With Worrisome Features (PERFORM Study): Rationale and Design of a Multicenter, Prospective, Observational, Cohort Study
Authors: Cao Longxiang , Zhou Jing , Chen Mingzhi , Chen Tao , Liu Man , Mao Wenjian , Lin Jiyan , Hong Donghuang , Yao Weijie , Sun Yi , Qin Kaixiu , Guo Feng , Zhou Yun , Jiao Qinghai , Chen Yingjie , Li Gang , Ye Bo , Ke Lu , Tong Zhihui , Liu Yuxiu , Li Weiqin ,   Chinese Acute Pancreatitis Clinical Trials Group (CAPCTG)
Published: December 2021

Background: Acute pancreatitis (AP) is a potentially life-threatening inflammatory disease with multiple etiologies. The prevalence of hypertriglyceridemia-induced acute pancreatitis (HTG-AP) has been increasing in recent years. It is reported that early triglyceride (TG) levels were associated with the severity of the disease, and TG- lowering therapies, including medical treatment and blood purification, may impact the clinical outcomes. However, there is no consensus regarding the optimal TG-lowering therapy, and clinical practice varies greatly among different centers. Our objective is to evaluate the TG-lowering effects of different therapies and their impact on clinical outcomes in HTG-AP patients with worrisome features.Methods: This is a multicenter, observational, prospective cohort study. A total of approximately 300 patients with HTG-AP with worrisome features are planned to be enrolled. The primary objective of the study is to evaluate the relationship between TG decline and the evolution of organ failure, and patients will be dichotomized depending on the rate of TG decline. The primary outcome is organ failure (OF) free days to 14 days after enrollment. Secondary outcomes include new-onset organ failure, new-onset multiple-organ failure (MOF), new-onset persistent organ failure (POF), new receipt of organ support, requirement of ICU admission, ICU free days to day 14, hospital free days to day 14, 60-day mortality, AP severity grade (Based on the Revised Atlanta Classification), and incidence of systemic and local complications. Generalized linear model (GLM), Fine and Gray competing risk regression, and propensity score matching will be used for statistical analysis.Discussion: Results of this study will reveal the current practice of TG-lowering therapy in HTG-AP and provide necessary data for future trials.
Characterization of the Canine Retinal Vasculature With Optical Coherence Tomography Angiography: Comparisons With Histology and Fluorescein Angiography
Authors: Ripolles-Garcia Ana , Ruthel Gordon , Ying Gui-Shuang , Chen Yineng , Cuenca Nicolas , Aguirre Gustavo D. , Beltran William A. 
Published: December 2021

Purpose: To present a methodology for quantification of the canine retinal vasculature imaged by optical coherence tomography angiography (OCTA) and validate this approach by comparison with fluorescein angiography (FA) and confocal imaging of retinal wholemounts labelled by immunohistochemistry (IHC).Methods: Six normal adult dogs underwent retinal OCTA imaging in both eyes. The images extracted from the different microvascular plexuses at eight retinal locations spanning the central and mid-peripheral fundus were analyzed using the AngioTool software. FA was performed in one eye and was compared to the OCTA images. Six eyes from three dogs were processed by IHC to examine the retinal vasculature.Results: A total of four retinal plexuses were identified by OCTA in the canine retina, and their density and topographical pattern varied with eccentricity. OCTA offered improved resolution over FA with the advantage of allowing imaging of the individual plexuses. Detection by OCTA of small vessels within the deep capillary plexus was possible and approached the level of resolution achieved with ex vivo imaging of the retinal vasculature by confocal microscopy/IHC. The plexuses herein described are analogous to human retinal vasculature.Conclusion: OCTA can be used to image and quantify non-invasively the vascular retinal networks of the canine retina. We provide normative data in eight different retinal locations that can be imaged non-invasively with this technology. This could support analysis of retinal vascular changes associated with disease and following therapeutic intervention.
Case Report: Anesthetic Management and Electrical Cardiometry as Intensive Hemodynamic Monitoring During Cheiloplasty in an Infant With Enzyme-Replaced Pompe Disease and Preserved Preoperative Cardiac Function
Authors: Liu Meng-Chen , Wang Ming-Tse , Chen Philip Kuo-Ting , Niu Dau-Ming , Fan Chiang Yu-Hsuan , Hsieh Ming-Hui , Tsai Hsiao-Chien 
Published: December 2021

Introduction: Pompe disease is caused by deficiency of the lysosomal enzyme acid α-glucosidase, which results in cardiac and muscular complications that can jeopardize perioperative outcomes. We report a 4-month-old infant with Pompe disease receiving cheiloplasty under general anesthesia with the aid of peripheral nerve blocks and intensive hemodynamic monitoring.Case Description: This case report describes a 4-month-old full-term Taiwanese female infant who presented with left unilateral cleft lip and palate in the prenatal examination. She was diagnosed with infantile-onset Pompe disease after acidic α-glucosidase (GAA) gene sequencing. She also received enzyme replacement therapy (ERT) 15 days after birth and regular ERT every other week. Cheiloplasty was performed under general anesthesia uneventfully, and peripheral nerve blocks were adopted for analgesia. Intensive hemodynamic monitoring using electrical cardiometry technology (ICON®) and pulse contour analysis (FloTrac system) were applied during the operation. No adverse effects were observed, and the wound healed well. Therefore, the patient was discharged 4 days after surgery.Conclusion: With the availability of ERT, severe organ dysfunction in infantile-onset Pompe disease patients is no longer common. However, moderate cardiac depression can still occur while increasing inspiratory pressure and deepening the anesthesia level despite a normal preoperative echocardiogram report. Therefore, careful, gradual titration is desirable. Furthermore, electrical cardiometry can detect hemodynamic changes more instantaneously and reliably than pulse contour analysis. In addition, we suggest taking advantage of the peripheral nerve block as a part of balanced anesthesia to alleviate the cardiac suppression caused by general anesthesia.
The Association Between Genetic Variants, Pharmacokinetics, and Infliximab Efficacy in Pediatric Patients With Crohn's Disease in China
Authors: Hu Wenhui , Feng Yan , Ye Ziqing , Tang Zifei , Qian Lai , Wang Yuhuan , Huang Ying 
Published: December 2021

Background: Infliximab is an effective therapy for Crohn's disease (CD). Early non-invasive predictors of disease remission allow for modification of treatments. The aim of this study was to investigate the associations between genetic variants, pharmacokinetics, and infliximab efficacy in pediatric patients with CD.Methods: This retrospective observational study included CD patients under infliximab therapy between August 2015 and December 2020. Information on demographics, laboratory tests, medication data, and disease activity index was collected. The trough levels of infliximab (TLI) and antibodies to infliximab (ATI) were measured at week 14, and reactive drug monitoring was performed during follow-up. Ten single-nucleotide polymorphisms involved in the NF-κB-mediated inflammatory response, pharmacokinetics, and therapeutic response to infliximab were genotyped.Results: A total of 62 pediatric CD patients were enrolled. The clinical remission (CR) rate was 69.4 and 63.2% at week 14 and week 30, respectively. TLI at week 14 was significantly independently associated with CR at week 14 and mucosal healing (MH) at week 30 (p = 0.007 and p = 0.025, respectively). The optimal TLI threshold level capable of distinguishing between the CR and non-CR groups was 2.62 μg/ml (p &lt; 0.001, area under the curve = 0.79, sensitivity = 69.2%, specificity = 78.9%), while that capable of distinguishing between the MH and non-MH groups was 3.34 μg/ml (p &lt; 0.001, area under the curve = 0.85, sensitivity = 78.6%, specificity = 79.4%). Rs3397 in TNFRSF1B was associated with time to ATI production in CD patients (p &lt; 0.001).Conclusions: Higher TLI contributed to achieving MH. Genotyping rs3397 in TNFRSF1B may identify patients who are prone to generating immunogenicity to drugs.
Integration of System Biology Tools to Investigate Huperzine A as an Anti-Alzheimer Agent
Authors: Khanal Pukar , Zargari Farshid , Far Bahareh Farasati , Kumar Dharmendra , R Mogana , Mahdi Yasir K. , Jubair Najwan K. , Saraf Shailendra K. , Bansal Parveen , Singh Ranjit , Selvaraja Malarvili , Dey Yadu Nandan 
Published: December 2021

Aim: The present study aimed to investigate huperzine A as an anti-Alzheimer agent based on the principle that a single compound can regulate multiple proteins and associated pathways, using system biology tools.Methodology: The simplified molecular-input line-entry system of huperzine A was retrieved from the PubChem database, and its targets were predicted using SwissTargetPrediction. These targets were matched with the proteins deposited in DisGeNET for Alzheimer disease and enriched in STRING to identify the probably regulated pathways, cellular components, biological processes, and molecular function. Furthermore, huperzine A was docked against acetylcholinesterase using AutoDock Vina, and simulations were performed with the Gromacs package to take into account the dynamics of the system and its effect on the stability and function of the ligands.Results: A total of 100 targets were predicted to be targeted by huperzine A, of which 42 were regulated at a minimum probability of 0.05. Similarly, 101 Kyoto Encyclopedia of Genes and Genomes pathways were triggered, in which neuroactive ligand–receptor interactions scored the least false discovery rate. Also, huperzine A was predicted to modulate 54 cellular components, 120 molecular functions, and 873 biological processes. Furthermore, huperzine A possessed a binding affinity of −8.7 kcal/mol with AChE and interacted within the active site of AChE via H-bonds and hydrophobic interactions.
Physical and Psychosocial Well-Being of Hospitalized and Non-Hospitalized Patients With COVID-19 Compared to the General Population in Qatar
Authors: Ouanes Sami , Al-Amin Hassen , Hussein Nurrunnazha Binti , Khan Faisal , Al Shahrani Ahmad , David Premalatha , Wali Amel Baker , Thapur Maliha , Karim Mustafa Abdul , Al Maslamani Muna , Al-Ansari Zainab , Ghuloum Suhaila 
Published: December 2021

Background: Many studies have shown a high prevalence of depression, anxiety, and stress symptoms in COVID-19 patients and the general population. However, very few studies directly examined the potential impact on the health-related quality of life (HRQoL), and none compared HRQoL in COVID-19 patients to the general population amid the pandemic.Methods: We carried out a cross-sectional study comparing HRQoL (as measured using the RAND Short Form 36 or SF-36 Health Survey) in randomly selected individuals from three different groups: hospitalized COVID-19 patients, quarantined COVID-19 patients, and controls from the general population in Qatar. We constructed a multivariate analysis of covariance (MANCOVA) to compare the SF-36 scores between the three groups and control for various covariates.Results: Our sample consisted of 141 COVID-19 inpatients, 99 COVID-19 quarantined patients, and 285 healthy controls. Surprisingly, we found that HRQoL was higher in COVID-19 hospitalized than in COVID-19 non-hospitalized patients than in controls. The main components where COVID-patients scored higher than controls were physical functioning and role limitations due to emotional problems. In COVID-19 patients, the female gender, older age, and past psychiatric history were associated with lower HRQoL.Conclusions: It seems that COVID-19 patient's HRQoL might be better than expected. Our results can be explained by social support from family and friends, easy access to mental health screening and care, and a possible change of perspectives after recovery from COVID-19, resulting in psychological growth and enhanced resilience.
Stigma Levels Toward Psychiatric Patients Among Medical Students—A Worldwide Online Survey Across 65 Countries
Authors: Babicki Mateusz , Małecka Monika , Kowalski Krzysztof , Bogudzińska Bogna , Piotrowski Patryk 
Published: December 2021

Background: According to epidemiological data, over 450 million people worldwide suffer from mental disorders, presenting one of the major challenges of modern medicine. In their everyday lives, patients, in addition to fighting the disease itself, often struggle with stigmatization. This phenomenon negatively affects both the diagnostic and therapeutic processes, as well as the patients' everyday functioning. This study aimed to assess stigma attitudes toward psychiatry and psychiatric patients among undergraduate medical students.Methods: This study used a Computer-Assisted Web Interview (CAWI), which included the standardized items from the Mental Illness: Clinicians' Attitudes (MICA-2) scale to evaluate stigma. The study was disseminated via the internet to students from medical universities from 65 countries worldwide. Participation was voluntary and anonymous. The study involved 1,216 students from these 65 countries. Most of the sample were women, and most were medical faculty students and students living in cities with more than 500,000 residents. Taking into consideration Gross Domestic Product (GDP) per capita and Human Development Index (HDI) variables, it can be seen that there was a prevalence of medical students from highly developed countries.Results: For the whole sample, the mean MICA-2 score was 40.5 points. Women and medical and nursing students showed more positive attitudes toward psychiatric patients. Students from countries with the highest economic development levels also achieved statistically lower MICA-2 scores. Lower score means a more positive attitude.Conclusion: Stigma toward both psychiatry and psychiatric patients is common among undergraduate medical students. Female students and respondents with a history of mental disorders in countries with high HDI and GDP per capita indices show more favorable attitudes than other medical students. There is a need to further our understanding of the problem of stigmatization, both among the general population and among medical personnel, and to implement and maintain appropriate measures to reduce stigma toward psychiatry.
Pure Laparoscopic Living Donor Hepatectomy With/Without Fluorescence-Assisted Technology and Conventional Open Procedure: A Retrospective Study in Mainland China
Authors: He Kang , Pan Yixiao , Wang Hai , Zhu Jianjun , Qiu Bijun , Luo Yi , Xia Qiang 
Published: December 2021

Background: The application of laparoscopy in donor liver acquisition for living donor liver transplantation (LDLT) has become increasingly popular in the past decade. Indole cyanide green (ICG) fluorescence technique is a new adjuvant method in surgery. The purpose was to compare the safety and efficacy of laparoscopic and open surgery in living donor left lateral hepatectomy, and to evaluate the application of ICG in laparoscopy.Methods: Donors received LDLT for left lateral lobe resection from November 2016 to November 2020 were selected and divided into pure laparoscopy donor hepatectomy (PLDH) group, fluorescence-assisted pure laparoscopy donor hepatectomy (FAPLDH) group and open donor hepatectomy (ODH) group. We compared perioperative data and prognosis of donors and recipients. Quality of life were evaluated by SF-36 questionnaires.Results: The operation time of PLDH group (169.29 ± 26.68 min) was longer than FAPLDH group (154.34 ± 18.40 min) and ODH group (146.08 ± 25.39 min, p = 0.001). The blood loss was minimum in FAPLDH group (39.48 ± 10.46 mL), compared with PLDH group (52.44 ± 18.44 mL) and ODH group (108.80 ± 36.82 mL, p=0.001). The post-operative hospital stay was longer in PLDH group (5.30 ± 0.98 days) than FAPLDH group (4.81 ± 1.03 days) and ODH group (4.64 ± 1.20 days; p = 0.001). Quality of life of donors undergoing laparoscopic surgery was better.Conclusion: Laparoscopic approaches for LDLT contribute to less blood loss, better cosmetic satisfaction. The fluorescence technique can further reduce bleeding and shorten operation time. In terms of quality of life, laparoscopic surgery is better than open surgery. Laparoscopy procedure for living-donor procurement with/without fluorescence-assist can be performed as safely as open surgery.
Comparison of Multi-Gene Testing Data Between Fresh and Formalin-Fixed Specimens From Core Needle Biopsy in Patients With NSCLC
Authors: Yao Zhi-Gang , Wei Zhi-Gang , Cheng Xian-Kui , Huang Guang-Hui , Zong Yuan-Yuan , Meng Min , Li Jia-Mei , Han Xiao-Ying , Xu Jia-Wen , Wang Jiao , Jing Hai-Yan , Li Wen-Hong , Cao Zhi-Xin , Ni Yang , Sun Xi-Chao , Yang Xia , Ye Xin 
Published: December 2021

Purpose: Currently, formalin-fixed paraffin-embedded (FFPE) tissue specimens are the conventional material for gene testing for non-small cell lung cancer (NSCLC) patients. In our study, we aimed to develop a quick gene testing procedure using fresh core needle biopsy samples from NSCLC patients.Methods: In total, 77 fresh NSCLC samples obtained from core needle biopsy were evaluated by frozen section examination. If the NSCLC diagnosis and adequate tumor cell counts were confirmed by histopathology, the fresh tissues were used to extract DNA and subsequent gene testing by ARMS-PCR. Meanwhile, the paired FFPE core needle biopsy samples from 30 NSCLC patients also underwent gene testing.Results: In total, 77 fresh samples showed an EGFR mutation rate of 61.0%, higher than the levels in the Asian. Following a comparison of gene testing results with fresh tissues and paired FFPE tissues from the 30 patients, no significant difference in the DNA concentration extracted from fresh tissues and FFPE tissues was found. However, DNA purity was significantly higher in fresh tissues than that in FFPE tissues. Gene testing detected the same gene mutations in 93.3% of cases in fresh tissues and paired FFPE tissues. The gene testing procedure using fresh biopsy samples greatly shortens the waiting time of patients.Conclusion: The multi-gene mutation testing using fresh core needle biopsy samples from NSCLC patients is a reasonable, achievable, and quick approach. Fresh tissues may serve as a potential alternative to FFPE tissues for gene testing in NSCLC patients.