bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic strategies and challenges in the management of craniospinal tumours in pregnancy: a 10-year retrospective tertiary centre study, systematic review, and proposal of treatment algorithms
Authors: Ghimire Prajwal , Pang Graeme , Philip Jerry , Hazem Sally , Rajwani Kapil , Lavrador Jose Pedro , Grahovac Gordon , Bleil Cristina , Thomas Nicholas , Gullan Richard , Vergani Francesco , Bhangoo Ranjeev , Ashkan Keyoumars 
Published: December 2021

Abstract
Objectives: The study aims to evaluate therapeutic strategies in the management of craniospinal tumours in pregnant patients and the factors that influence the management along with their influence on maternal & foetal outcomes. Materials and Methods:A retrospective single-centre cohort study was performed at a tertiary neurosurgical referral centre. Pregnant patients referred to neuro-oncology multidisciplinary meeting (MDM) with craniospinal tumour were included. Ten-year patient data were collected from hospital records and neuro-oncology MDM outcomes. A systematic review was performed on the available literature in PubMed as per PRISMA guidelines. Results:Thirty-three patients were identified with a mean age of 31 years. 91%(n=30) had cranial lesions and 9%(n=3) had spinal lesions. Most of the patients had WHO Grade I/II tumours. 33.3% underwent surgery when pregnant whilst in 24.2% this was deferred until after the due date. 27.2% patients did not require surgical intervention and were followed up with serial imaging in the MDM. Left Lateral/park bench position was the preferred position for the spinal and posterior fossa lesions. Systematic review identified 26 eligible articles. Treatment algorithms are proposed addressing the therapeutic strategy for management of cranio-spinal tumours during pregnancy and the challenges for maternal and foetal outcomes were tabulated. Conclusions:Craniospinal tumours presenting in pregnancy are challenging. The surgical management needs to be tailored individually and as part of a multidisciplinary team approach. Maternal and foetal outcomes are to be considered during patient counselling.
Environmental protection and pollution prevention: What determines the intention of tea farmers’ ecosystem construction
Authors: ShaLou  , Zhang Bingru , Zhang Dehua 
Published: December 2021

Abstract

Pesticide is inevitable in the process of tea production. Residual chemical pesticides absorbed by human body and soil will pose a great threat to human health. The construction of tea garden ecosystem that uses the principle of mutual restriction between species can effectively reduce the number of pests and the dependence on pesticides. In order to improve the adoption and attention of green production among farmers, the government strongly supports rural financial institutions to lend to farmers and encourages resources to be inclined to farmers. The aim of this study was to find out what factors affect the intention of tea farmers’ ecosystem construction and the differences of influence on intention of Chinese tea farmers' ecosystem construction under different financing modes. The results of the empirical research showed that the attitude, perceived behavioral control and subjective norms of tea farmers have a significant positive impact on the behavioral intention. And for tea farmers who get bank financing, the influencing intensity and significance of factors are different from those who obtain private credit. This study provided a theoretical basis for government to promote the development of ecosystem construction in the agricultural section, and put forward suggestions for financial institutions to serve environmental protection.
Perceptions of Healthcare Professionals on Covid-19 in Lesotho: a Cross-sectional Survey
Authors: Nyangu Isabel , Ramathebane Maseabata 
Published: December 2021

Abstract
BackgroundHealth care professionals at the frontline of the Covid-19 pandemic require continued support to ensure not only their well-being, but enhanced care for those infected by the disease.AimThe aim of this study was to assess the perceptions of health care providers regarding the Covid-19 pandemic in Lesotho. MethodologyA quantitative cross-sectional survey design was used to collect data from a sample of 190 health care workers who were conveniently sampled from a total of 25 health care facilities (12 hospitals and 13 health center clinics). The sample included nurses, doctors, pharmacists, laboratory scientists/ technicians, dentists, counsellors, and administrative assistants. A total of 255 structured questionnaires were distributed and 190 of them were returned completed (75% response rate). Data were collected in September 2021 and analyzed using SPSS (vs23). Permission to conduct this study was granted by the relevant authorities. Informed written consent was given by the participants in writing before they could take part in this study.ResultsThe level of education was found to be associated with positive perceptions of the respondents on the Covid-19 pandemic. Respondents generally had positive views about the Covid-19 pandemic. Their views were positive as they understood that Covid-19 can affect anyone including themselves and is not a disease for any particular race. They were also aware that they could contract Covid-19, even despite pre-existing conditions. Respondents perceived that there was a positive prognosis after contracting Covid-19 if necessary precautions were taken. They had positive perceptions as they knew that the virus was affecting many people worldwide, including the elderly, and were willing to take the test and did not mind having to pay for it if asked to do so. Even though the Covid-19 test was viewed not to take too much time, respondents felt that it is rather painful and uncomfortable. The test providers were perceived as friendly and not rude, and respondents did not have any preferred gender for the test providers. Respondents were also willing to discuss issues on Covid-19 with families and friends. Majority of the respondents lived close to health care facilities.ConclusionsThis study concludes that health care providers at the frontline were mostly nurses. Positive perceptions about the Covid-19 pandemic in Lesotho were found as respondents were knowledgeable, and were willing to test for the disease. Test providers were viewed as pleasant and health care facilities were accessible. This shows positive progress towards fighting the pandemic in Lesotho.RecommendationsSupport for frontline healthcare professionals remains crucial to ensure effective service delivery. More education can be provided to improve the general views about the Covid-19 to improve uptake of services not only amongst healthcare professionals but the general public as well.
Bilateral Basal Ganglia Infarction and Bilateral Thalamic Lesions in Sudanese Pediatric Patient with COVID-19 and Malaria Co-Infection, a Case Report
Authors: Abdelrahim Abdalla Yassin , Shaban Mohannad Abdalfdeel Almahie , Ahmed Khabab Abbasher Hussien Mohamed , Haroun Mazin S. , Eljack Moh.Mah.Fadelallah , Eltom Khalid Sidahmed , Elhassan Rasha Sidahmed 
Published: December 2021

Abstract
COVID-19 is of uncommon diagnosis in pediatric with their presentation in much of time of a nonspecific entity; here we experienced a case of two years old female with Malaria presented with fever, cough, rhinorrhea, hemoptysis and convulsion diagnosed as COVID-19, complicated with encephalitis, received treatment and improved over weeks.
The Spectrum of Children's Kidney Diseases—2403 Renal Biopsy-Proven Cases from a Single Centre in China Between 1999 and 2019
Authors: Jiang Li-Jun , Rong Zan-Hua , Zhao Xue , Dou Zhi-Yan , Yang Lin 
Published: December 2021

Abstract
Background: This study aimed to investigate the clinical and pathological characteristics and the changes in glomerular diseases in 2403 pediatric renal biopsies from 1999 to 2019.Methods: Renal biopsies performed on children aged ≤18 years between 1999 and 2019 were analysed at our center. We analysed the clinical and histological characteristics, distribution of pediatric glomerular diseases with various clinical presentations, and changes in the glomerular disease patterns during the study period.Results: The most common primary glomerular disease was IgA nephropathy (IgAN) (24.3%), followed by minimal change disease (MCD) (15.3%) and membranous glomerulonephritis (MN) (13.1%). Henoch-Schonlein purpura nephritis (HSPN) (18.1%) and lupus nephritis (LN) (7.2%) were the most frequently recorded secondary glomerular diseases. Alport syndrome and thin basement membrane nephropathy (TBMN) were the most common inherited glomerular diseases, accounting for 1.2% and 0.6% of the total glomerular diseases in children, respectively. The number of boys with IgAN, MCD and IgM nephropathy (IgMN) was higher than that of girls, while the number of girls with MN and LN was higher than that of boys. The frequencies of MCD, MN, IgMN and endocapillary proliferative glomerulonephritis (EnPGN) in the 13-18-year-old group were higher than those in the 0-12-year-old group, while the frequencies of IgAN, mesangial proliferative glomerulonephritis (MsPGN) and focal proliferative glomerulonephritis (FPGN) were lower than those in the 0-12-year-old group. The ratio of Alport syndrome and TBMN in the 0-12-year-old group was higher than that in the 13-18-year-old group. The proportion of patients with MCD and MN in 2010-2019 was higher than that in 1999-2009, while the ratio of IgAN, MsPGN, IgMN, EnPGN, membranoproliferative glomerulonephritis (MPGN), HSPN and HBV-associated glomerulonephritis (HBV-GN) decreased. MCD (28.5%) was the most common cause of nephrotic syndrome (NS). In children with haematuria and proteinuria, HSPN (38.8%) and IgAN (36.9%) were more common than other glomerular diseases. IgAN (39.4%) was the most common cause of AKI. Sclerosing glomerulonephritis (SGN) (21.1%) was the main cause of progressive chronic kidney disease (CKD).Conclusions: Glomerular diseases in children were related to sex and age. From 1999 to 2019, the spectrum of children's kidney disease in our center changed significantly.
Construction and Empirical Analysis of Citizens' Water Literacy Evaluation Index System: A Structural Equation Model
Authors: KANG TIAN 
Published: December 2021

Abstract
This study draws on the existing water literacy evaluation system and the weight of each indicator to construct a three-dimensional theoretical analysis framework of water knowledge, water attitude, and water behaviour. Based on the constructed evaluation index system, research hypotheses were proposed, questionnaires designed, and areas of Beijing, Zhengzhou, Hechi, Qingtongxia selected for investigation. According to the constructed structural equation model of citizen water literacy, the influence degree of the influence factors of citizen water literacy evaluation on the path is discussed. The coefficient of the influence degree of each factor on water literacy is obtained. The research results show that: 1) water knowledge has a positive and significant influence on water attitude; 2) water attitude has a positive and significant impact on water behaviour; 3) water behaviour has a positive and significant impact on water literacy. 4) The following two hypotheses, that water knowledge has a positive and significant effect on water behaviour, and water attitude has a positive and significant effect on water literacy, are shown not to hold. The research conclusions can provide a theoretical basis for the water sector to formulate relevant policies to improve water literacy.
The Measurements of Frailty and Their Possible Application to Spinal Conditions. A Systematic Review
Authors: Moskven Eryck , Charest-Morin Raphaële , Flexman Alana M. , Street John T. 
Published: December 2021

Abstract
Background: Frailty is associated with an increased risk of postoperative adverse events (AEs) within the surgical spine population. Multiple frailty tools have been reported in the surgical spine literature. However, the applicability of these tools remains unclear. The primary objective of this systematic review is to appraise the construct, feasibility, objectivity, and clinimetric properties of frailty tools reported in the surgical spine literature. Secondary objectives included determining the applicability and the most sensitive surgical spine population for each tool. Methods: This systematic review was registered with PROSPERO: CRD42019109045. Publications from January 1950 to December 2020 were identified by a comprehensive search of PubMed, Ovid, Embase, and Cochrane, supplemented by manual screening. Studies reporting and validating a frailty tool in the surgical spine population with a measurable outcome were included. Each tool and its respective clinimetric properties were evaluated using validated criteria and definitions. The applicability of each tool and its most sensitive surgical spine population was determined by panel consensus. Bias was assessed using the Newcastle-Ottawa Scale.Results: 47 studies were included in the final qualitative analysis. A total of 14 separate frailty tools were identified, in which nine tools assessed frailty according to the cumulative deficit definition, while four instruments utilized phenotypic or weighted frailty models. One instrument assessed frailty according to the comprehensive geriatric assessment (CGA) model. Twelve measures were validated as risk stratification tools for predicting postoperative AEs, while one tool investigated the effect of spine surgery on postoperative frailty trajectory. The modified frailty index (mFI), 5-item mFI, adult spinal deformity frailty index (ASD-FI), FRAIL Scale, and CGA had the most positive ratings for clinimetric properties assessed. Conclusions: The assessment of frailty is important in the surgical decision-making process. Cumulative deficit and weighted frailty instruments are appropriate risk stratification tools. Phenotypic tools are sensitive for capturing the relationship between spinal pathology, spine surgery, and prehabilitation on frailty trajectory. CGA instruments are appropriate screening tools for identifying health deficits susceptible to improvement and guiding optimization strategies. Studies are needed to determine whether spine surgery and prehabilitation are effective interventions to reverse frailty.
SNP-Based Breeding for Broiler Resistance to Ascites and Evaluation of Correlated Production Traits
Authors: Lee Katie Pepper , Anthony Nicholas B , Orlowski Sara K , Rhoads Douglas 
Published: December 2021

Abstract
Background: The goal of this study was to evaluate marker-assisted selection (MAS) in broiler chickens using previously mapped gene regions associated with ascites syndrome incidence. The second-generation MAS products were assessed for impact on ascites phenotype and whether there were associated changes in important production traits. Previously, we used whole genome resequencing (WGR) to fine-map 28 chromosomal regions as associated with ascites phenotype in our experimental ascites broiler line (Relaxed, REL) based on a hypobaric chamber challenge. Genotypes for single nucleotide polymorphisms (SNPs) in mapped regions on chromosomes 2 and 22, were used for MAS in our REL line. After two generations, birds homozygous for the genotypes associated with resistance for both chromosomal regions were established. The MAS F 2 generation was then compared to the REL line for ascites susceptibility and 25 production traits. Results: Selection based on SNPs in the carboxypeptidase Q (CPQ, Gga2) and leucine rich repeat transmembrane neuronal 4 (LRRTM4, Gga22) gene regions resulted in a sex- and simulated altitude- dependent reduction of ascites incidence in two F 2 cohorts of the MAS line. Comparisons of the F 2 MAS and REL lines for production traits when reared at ambient pressure found no significant negative impacts for feed intake (FI), feed conversion ratio (FCR), or deboned part yields for either sex for two F 2 cohorts. There were, however, improvements in the MAS for full-trial body weight gain (BWG), FCR, absolute and relative tender weights, and relative drumstick weight. Conclusions: These results validate the mapping of the 28 chromosomal regions and demonstrate that fine mapping by WGR is an effective strategy for addressing a complex trait; it also stands as the first successful SNP-based selection program against a complex disease trait, such as ascites. The MAS line is comparable and, in some instances, superior, in growth performance to the REL control while being more resistant to ascites. This study indicates that MAS based on WGR can provide significant breeding potential in agricultural systems.
Detection of structural variations and fusion genes in breast cancer samples using third-generation sequencing
Authors: Hu Taobo , Li Jingjing , Long Mengping , Wu Jinbo , Zhang Zhen , Xie Fei , Zhao Jin , Yang Houpu , Song Qianqian , Lian Shen , Shi Jiandong , Guo Xueyu , Yuan Daoli , Lang Dandan , Yu Guoliang , Liang Baosheng , Zhou Xiaohua , Ishibashi Toyotaka , Fan Xiaodan , Yu Weichuan , Wang Depeng , Wang Yang , Peng I-Feng , Wang Shu 
Published: December 2021

Abstract
Background: Structural variations (SVs) are common genetic alterations in the human genome that could cause different phenotypes and various diseases including cancer. However, the detection of structural variations using the second-generation sequencing was limited by its short read-length which in turn restrained our understanding of structural variations. Methods: In this study, we developed a 28-gene panel for long-read sequencing and employed it to both Oxford Nanopore Technologies and Pacific Biosciences platforms. We analyzed structural variations in the 28 breast cancer-related genes through long-read genomic and transcriptomic sequencing of tumor, para-tumor and blood samples in 19 breast cancer patients. Results: Our results showed that some somatic SVs were recurring among the selected genes, though the majority of them occurred in the non-exonic region. We found evidence supporting the existence of hotspot regions for SVs, which extended our previous understanding that they exist only for single nucleotide variations. Conclusions: In conclusion, we employed long-read genomic and transcriptomic sequencing in identifying SVs from breast cancer patients and proved that this approach holds great potential in clinical application.
Environmental and legal policy: modern approaches to formation
Authors: Getman Anatolii P. , Anisimova Anna 
Published: December 2021

The article considers environmental law policy as a component, an independent type of national legal policy, as well as state and sectoral environmental policy. The existence of correlative, mutual influence of ecological and legal doctrine on formation of the corresponding policy is proved. It is substantiated that the ecological and legal legal doctrine significantly influences the current state of the state ecological policy (and this influence is mutual), formation of the ecological legislation and integration of Ukraine into the European legal space. It was stated that Ukraine first of all needs to intensify law-making, modernize the provisions of the environmental and legal doctrine, based on the concepts of which will be revised, updated provisions of public policy, legal understanding, and hence law enforcement. Further institutionalization of the basic provisions of the ecological and legal doctrine in the legislation becomes a necessary condition for the further development of law-making and statehood.
It is emphasized that the use of environmental and legal doctrine will speed up the law-making process, in particular due to the adaptation of regulations to European standards; formulate legislative definitions that will gradually become an important part of environmental regulations; develop a "road map" for the development of environmental policy and legislation, etc.
It is emphasized that the current state of the legal system requires a fuller use of the law-making potential of environmental law doctrine and the implementation of its main functions - stabilizing, guiding, heuristic, rule-making, evaluative and prognostic. Therefore, it is expedient to apply the ecological and legal doctrine as a methodological platform of the ecological and legal policy. The necessity of developing concepts of systematization of the ecological legislation, and also legal policy is proved.
US Flood risk management in changing times
Authors: Baecher Gregory B. , Galloway Gerald E. 
Published: December 2021

Abstract
The traditional regulatory and policy approach to flood risk in the US has been the optimization of benefits and costs, broadly mandated by federal policy. However, optimization may not be the best approach to flood risk management in light of the deep uncertainties we now face. A more incremental approach using a satisficing strategy may be. Flood risk is a function of the hydrologic factors that produce a hazard and the consequences of the hazard interfacing with the people and property exposed. Regretfully, both hydrologists and climatologists seem unable to provide the clairvoyant guidance needed by the water community facing major decisions on flood risk management in the coming years. As the seminal ‘Red Book’ noted, two things have become second nature to policy analysts and risk managers: absolute safety is unachievable, and it is necessary to distinguish between science and policy. The forcing elements and largest unknowns in determining risk rest with understanding the hydrologic factors involved in shaping the hazard.
The centrality of engineering codes and risk-based design standards in climate adaptation strategies
Authors: Stakhiv Eugene Z. 
Published: December 2021

Abstract
Engineering codes, design standards and analytical criteria for hydraulic structures are the final determinative specifications for designing and constructing a water resources project. As such, they are the authoritative and legally accepted standards for project design and construction. Engineering codes and standards are developed to optimize public safety and performance by focusing on structural reliability, which includes a wide range of extreme conditions that encompass most contemporary climate uncertainties, and which are likely to overlap some portion of future climate non-stationary conditions. Current practices of risk-based planning and design standards have evolved incrementally, responding to each catastrophic natural disaster, whether it is geotechnical, floods, droughts or hurricanes. Design standards and building codes encompass an accumulation of changes that progressively reflect changing climate conditions, most notably because they focus on climate extremes. Design standards and embedded ‘safety factors’ that are based on extremes are likely to encompass a good deal of an anticipated non-stationary climate regime and its associated uncertainties. Modern risk analysis methods and risk-based standards, codes and methods comprise an important part of a progressive autonomous adaptation to climate change. They represent an essential component of ‘no regrets’ climate adaptation.