bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of C/SiC Fasteners for High-Temperature Applications
Authors: Kumar Shobhit , Painuly Anil , Kamal Anurag , Kuttappan Sajimon , Kumar Ravi Ranjan , Prabhakaran Shyin Palani , Devasia Renjith 
Published: April 2021

Abstract
Continuous carbon fiber reinforced silicon carbide (C/SiC) ceramic matrix composites are the candidate materials for high-temperature structural applications owing to their high specific strength, low coefficient of thermal expansion, and moderate thermal conductivity. C/SiC based fasteners provide reliability with oxidation resistance up to 1,650°C for joining such C/SiC structural components used in reusable launch vehicles for space applications. The present study describes the methodology to realize C/SiC based M8 fasteners by isothermal-isobaric chemical vapor infiltration process using 2D-stitched carbon fabric preforms. The realized fasteners exhibited a density of 2.10 g/cm3, a tensile strength of 191 ± 3 MPa, a shear strength of 230 ± 69 MPa in non-threaded and 150 ± 86 MPa in threaded regions of shank at room temperature, a high-temperature tensile strength of 170 ± 12 MPa, and a tensile modulus of 70 ± 8 GPa at 1,100°C in the atmospheric conditions. The tensile failure of the C/SiC bolts was observed to depend upon the relative dimensions of fillet radius and thread root radius, wherein a small fillet radius was observed to be detrimental, as it resulted in failure at the head-shank interface of the bolts. The scanning electron microscope images of tensile tested C/SiC bolts indicate extensive fiber pullout, characteristic of quasi-ductile failure of bolts. It is clearly evident from the studies that the C/SiC fasteners are a promising alternative over the currently used molybdenum alloy fasteners.
Mo-Silicide Alloys for High-Temperature Structural Applications
Authors: Perepezko J. H. , Krüger M. , Heilmaier M. 
Published: April 2021

Abstract
The challenges of a high-temperature environment (T &gt; 1,400°C) impose severe material performance constraints in terms of melting point, oxidation resistance, and structural functionality. A number of ceramic materials, intermetallic compounds, and refractory metals with high melting temperatures are available as material choices. However, in a single-component single-phase form, these materials do not satisfy all the aforementioned requirements. One clear message from the evolutionary development of high-temperature alloys is the importance of developing multicomponent alloys with multiphase microstructures and the capability to control phase fractions and morphologies to satisfy a number of mechanical property requirements. Besides the essential structural requirements, elevated temperatures often also involve aggressive environments that require a material to display an inherent oxidation protection that can be further enhanced by coating. Among the leading candidates to advance beyond the capability of the current nickel (Ni)-base superalloys, the multiphase microstructures that can be developed in the molybdenum-silicon-boron (Mo-Si-B) system involving a high melting temperature (&gt;2,100°C) ternary-based intermetallic Mo5SiB2 (T2) offer an attractive performance. Most of the attention has been on three-phase alloys comprised of Mo(ss), T2, and Mo3Si that offer high-temperature stability and robust microstructures, but new alloy designs are in development. In this review the recent advances in the development of Mo-silicide alloys are discussed in terms of alloy design, microstructure control, structural performance, environmental resistance, and component analysis.
Validation of a Set of Stimuli to Investigate the Effect of Attributional Processes on Social Motivation in Within-Subject Experiments
Authors: Fucci Enrico , Baquedano Constanza , Abdoun Oussama , Deroche Jessy , Lutz Antoine 
Published: April 2021

Attribution of responsibility for the causes of suffering is one of the main factors that influence responses to individuals in distress. While the role of attributional processes on prosocial motivation has been widely investigated in social psychology, only few attempts have been made to characterize their behavioural and neurophysiological underpinnings. This is partly due to the lack of stimuli that can facilitate within-subject experimental designs. To overcome this problem, we created a set of stimuli consisting of videos depicting people in different situations of distress. Each video is paired with short stories that aim to manipulate the perceived degree of responsibility of the main character.
To validate the stimuli, we investigated the effect of different context-video pairs on self-report measures of participants’ subjective experience. We found that different contexts preceding the same video can influence blame and responsibility judgments, affective responses and willingness to help.
In a complementary analysis, we replicated previous findings on the influence of empathy and responsibility on willingness to help, showing how the latter is mediated by moral judgments.
Finally, we observed a general increase in responses times when videos were paired with responsible contexts. We provide interpretations of this finding that can relate attribution accounts to prominent theories in moral psychology.
Overall, this study highlights the possibility of expanding existing theories on prosocial motivation by implementing a set of stimuli that includes multiple scenarios and allows for the collection of third person measures in within-subject designs.
La Antropología y el estudio de la Geografía Leif
Authors: Korsbaek Leif 
Published: April 2021

Introducción
Así como la Antropología mantiene vínculos con la disciplina más especulativa de todas, la Filosofía, también mantiene relaciones con una de las disciplinas más terrenales, con la Geografía, ciencia de la Tierra. A un nivel elemental, podemos decir que un antropólogo que se dirige al campo sin buscar la información básica acerca de la colocación de su comunidad o región, los tipos de suelos, vegetación, orografía, etc., está literalmente “perdido en el espacio”.
Teleodontología para la atención de pacientes durante la pandemia de la COVID-19. Revisión de literatura
Authors: Matta Sandra Viviana Caceres , Carmona Arango Luis Eduardo 
Published: April 2021

Objetivo: describir las aplicaciones de la teleodontología para la atención de pacientes durante y posterior a la pandemia de la COVID-19. Método: la búsqueda de artículos sobre teleodontología se realizó en las bases de datos PubMed, EMBASE, EBSCO, SCOPUS, ClinicalKey y LILACS, para identificar estudios publicados en inglés, español y portugués; se incluyeron estudios que contenían las palabras claves teleodontología y COVID-19, publicados desde enero a diciembre de 2020 y que estuvieran completos. La calidad de los artículos se evaluó según las directrices PRISMA-P. Resultados: se identificaron 49 artículos y se incluyeron 14 para la evaluación. De estos estudios, dos eran descriptivos (test de diagnóstico), seis eran estudios descriptivos de corte transversal, cinco eran pruebas pilotos; se identificó, además, un estudio de diseño retrospectivo. Se presenta la teleodontología como alternativa para diagnósticos y tratamientos de enfermedades bucales en tiempos de pandemia, mediante uso de dispositivos móviles, teleorientación y fotografías. La mayoría de los estudios presentaron un riesgo de sesgo de moderado a alto. Conclusión: la teleodontología es una herramienta tecnológica remota para apoyar la orientación, educación y tratamiento, que permite consolidar información de manera sincrónica y asincrónica sin la necesidad del contacto directo entre odontólogo y paciente.
Editorial
Authors: Rodríguez Reyes Abraham 
Published: April 2021

En desafortunada coincidencia con una nueva serie de actos de agitación interna y de hechos externos que por tener que ver negativamente con la Universidad Nacional son mucho más alarmantes, sale a circulación el tercer número de nuestra revista INGENIERIA E INVESTIGACION, órgano de divulgación de la Facultad de Ingeniería y con el cual mostramos a la comunidad universitaria y a la opinión Pública en general que la vida académica y el espíritu científico siguen su derrotero no obstante la anarquía y el amedrentamiento con que una minoría violenta, enquistada en el mismo ámbito universitario, trata de imponer los oscuros designios de mentes o ideologías extrañas a la Universidad, quizás sin entender o sin querer entender que con estas actitudes sólo han logrado el desprestigio de la institución y el paulatino deterioro de la misma.
Cálculo de disturbios atmosféricos, a partir del nivel isoceráunico: con datos reales comparativos para Alemania Federal, y curvas características de choque.
Authors: Torres Sánchez Horacio 
Published: April 2021

El número de disturbios sobre una línea aérea, debidos a fenómenos atmosféricos, depende en primer lugar del Nivel lsoceraunico del área atacada. Esto significa, cuantos días tormentosos al año son esperados en un área determinada. Como día tormentoso es tomado aquel durante el cual, como mínimo, un trueno es oído. En las cercanías al Ecuador se dan hasta 200 días tormentosos al año. (Amazonas y África Central) mientras que en las proximidades a los polos es prácticamente cero.
Una solución al problema del configurador basado en la matriz de admitancia
Authors: Parra L. Estrella E. , Florez C. Lucio 
Published: April 2021

El problema de la determinación de la topología de la red es aparentemente simple, pero debido a la operación normal del sistema la configuración de la red varía constantemente.
Los cambios en el estado de los interruptores de potencia pueden producir varios efectos como, por ejemplo:

— Conexión (o desconexión) de líneas, transformadores y generadores.

— Aumento (o disminución) del número de nodos del sistema debido a la separación de barrajes en subestaciones.

— Formación de subsistemas aislados debido a la apertura de líneas de interconexión.

Estos cambios implican que ciertos elementos de la red pueden quedar inhabilitados en análisis de flujo de carga o estimación de estado. Sus efectos se reflejan en la alteración del ordenamiento de los nodos que se efectúa para optimizar los requerimientos de memoria necesarios en muchas aplicaciones de sistemas de potencia.

Para tener en cuenta estos cambios en la topología se debe contar con un algoritmo que permanentemente reciba la información de la posición de los Interruptores y el estado de las medidas para tener en cada instante la configuración real de la red. Quizás el sistema de determinación de la topología de la red más popular es el conocido como configurador AEP, pero en este artículo no se describe en detalle. Únicamente trata un algoritmo implementado en el Departamento de Ingeniería eléctrica de la Universidad Nacional que usa las características de la matriz de admitancia del sistema.
stema.
Cause analysis and risk evaluation of the occurrence of Campylobacter spp. in the broiler production chain
Authors: Berkics A. , Varga V. , Mohácsi-Farkas Cs. , Jóźwiak Á.B. 
Published: April 2021

AbstractTendencies of foodborne outbreaks show that the number of illnesses caused by Campylobacter spp. has been increasing recently in the European Union and in Hungary as well. However, the epidemiological statuses of Member States are diverse. There are several aspects to be investigated by competent authorities before the introduction of interventions. Methods supporting food safety decision making range from quick and easy techniques to complex, resource consuming approaches. The aim of the present study was the implementation of an evaluation and ranking system for a risk and its causes occurring in the broiler production chain. Data and information available in scientific literature were converted to a structured easy-to-use evaluation that supports decision making and helps structured data processing.
CT texture analysis of abdominal lesions – Part II: Tumors of the Kidney and Pancreas
Authors: Frank Veronica , Shariati Sonaz , Budai Bettina Katalin , Fejér Bence , Tóth Ambrus , Orbán Vince , Bérczi Viktor , Kaposi Pál Novák 
Published: April 2021

AbstractIt has been proven in a few early studies that radiomic analysis offers a promising opportunity to detect or differentiate between organ lesions based on their unique texture parameters. Recently, the utilization of CT texture analysis (CTTA) has been receiving significant attention, especially for response evaluation and prognostication of different oncological diagnoses. In this review article, we discuss the unique ability of radiomics and its subfield CTTA to diagnose lesions in the pancreas and kidney. We review studies in which CTTA was used for the classification of histology grades in pancreas and kidney tumors. We also review the role of radiogenomics in the prediction of the molecular and genetic subtypes of pancreatic tumors. Furthermore, we provide a short report on recent advancements of radiomic analysis in predicting prognosis and survival of patients with pancreatic and renal cancers.
“Cube house” refurbishment in Hungary – A simulation-based approach
Authors: Ali Modar , Kistelegdi István 
Published: April 2021

AbstractAbout 800,000 of “Cube houses” which date back to the socialist era are still in use throughout Hungary. These houses are considered to be “outdated” and they bring not only energy but also social issues. This paper presents a refurbishment design solution for the cube house, combining vernacular architecture with modern solutions within the framework of Solar Decathlon Europe 19 competition. The paper investigates the comfort and energy improvement of the refurbished design. Thermal simulation results revealed considerable improvements, which can be considered and implemented to a big proportion of family houses with analogous dimensions, under similar climate conditions.
Calibration of energy simulation model for three buildings in Kosovo
Authors: Rashani Miranda , Mahdavi Ardeshir 
Published: April 2021

Abstract
The energy performance of residential buildings depends on a large number of interrelated factors. The present paper outlines an approach to developing a building thermal simulation model through real-time data and sensitivity analyses. To this end, three existing multi-family apartment buildings in Pristina, Kosovo, were selected. Initially, thermal simulation models were created using multiple data sources. Model outputs were further evaluated via comparison with available and measured data. Consequently, the most influential input parameters were identified and adjusted to calibrate the models. The resulting calibrated models can be deployed to investigate the potential of alternative retrofit measures.
Short-Term Pravastatin Mediates Growth Inhibition and Apoptosis, Independently of Ras, via the Signaling Proteins p27Kip1 and PI3 Kinase
Authors: WEISS ROBERT H. , RAMIREZ AL , JOO ADRIANE 
Published: April 2021

Abstract.
Growth factor-stimulated DNA synthesis in a variety of cell lines has been shown to be decreased after overnight (or longer) treatment with the 3-hydroxy-3-methylglutaryl CoA reductase inhibitors, the statins. Although this anti-mitogenic effect had been presumed to be the result of the impairment of Ras lipidation, a stable modification (T1/2 approximately 20 h), this study provides new data demonstrating that brief (approximately 1 h) pretreatment of rat vascular smooth muscle cells with 100 μM pravastatin before platelet-derived growth factor-BB (PDGF-BB) stimulation results in attenuation of DNA synthesis through a Ras-independent mechanism. PDGF-BB-stimulated PDGF-β receptor tyrosine phosphorylation, Ras activity, and mitogen-activated protein/extracellular signal-regulated kinase activity are unaffected by from 10 min to 1 h of pravastatin incubation, while Raf activity is markedly increased after 1 h of pravastatin. Phosphatidylinositol-3 kinase activity and phosphorylation of its downstream effector Akt are decreased after 1 h pravastatin incubation. Rho is stabilized by pravastatin, and ADP-ribosylation of Rho by C3 exoenzyme decreases PDGF-stimulated phosphatidylinositol-3 kinase activity, mimicking the effect of pravastatin on this signaling protein. Levels of the cyclin-dependent kinase inhibitor p27Kip 1 are increased when cells were preincubated with pravastatin for 1 h and then exposed to PDGF, and apoptosis is induced by pravastatin incubation times as short as 1 to 4 h. Thus, short-term, high-dose pravastatin inhibits vascular smooth muscle cell growth and induces apoptosis independently of Ras, likely by means of the drug's effect on p27Kip 1, mediated by Rho and/or phosphatidylinositol-3 kinase. This work demonstrates for the first time that the statins may be therapeutically useful when applied for short periods of time such that potential toxicity of long-term statin use (such as chronic Ras inhibition) may be avoided, suggesting future therapeutic directions for statin research.
Effect of Protein A Immunoadsorption in Nephrotic Syndrome of Various Etiologies
Authors: ESNAULT VINCENT L. M. , BESNIER DOMINIQUE , TESTA ANGELO , COVILLE PIERRE , SIMON PIERRE , SUBRA JEAN-FRANC[COMBINING CEDILLA]OIS , AUDRAIN MARIE A. P. 
Published: April 2021

Abstract.
Protein A immunoadsorption (IA) has proved effective in reducing proteinuria in patients with nephrotic syndrome after recurrence of focal and segmental glomerulosclerosis (FSGS) in kidney transplants. The effect of IA in nephrotic syndrome of other etiologies remains unknown. Nine patients with nephrotic syndrome secondary to membranous nephropathy (four cases), diabetes mellitus (one case), IgA nephropathy (two cases), and amyloidosis (two cases) had three to five IA of 2.5 plasma volumes over 4 to 8 d. Patients received no concomitant immunosuppressive treatment, and antihypertensive drugs were left unchanged. Proteinuria decreased from 12.64 ± 5.49 to 3.35 ± 2.2 g/24 h (mean ± SD) in all patients after three to five IA. Hematocrit decreased from 37.32 to 32.64% (12.5% hemodilution) and serum albumin from 25.43 to 18.6 g/L (26.4% decrease). Proteinuria returned to baseline levels within 1 mo, as described in recurrent FSGS following transplantation. When serum albumin balance was controlled by albumin infusion after IA in two patients, comparable decreases in proteinuria were observed. Therefore, IA is effective in producing short-term reduction of proteinuria in nephrotic syndromes related not only to FSGS but also to membranous and IgA nephropathies, diabetes mellitus, and amyloidosis, which suggests that IA removes a nonspecific circulating hemodynamic-altering or permeability-increasing factor.
The Glomerular Epithelial Cell Anti-Adhesin Podocalyxin Associates with the Actin Cytoskeleton through Interactions with Ezrin
Authors: ORLANDO ROBERT A. , TAKEDA TETSURO , ZAK BEVERLY , SCHMIEDER SANDRA , BENOIT VIVIAN M. , MCQUISTAN TAMMIE , FURTHMAYR HEINZ , FARQUHAR MARILYN G. 
Published: April 2021

Abstract.
During development, renal glomerular epithelial cells (podocytes) undergo extensive morphologic changes necessary for creation of the glomerular filtration apparatus. These changes include formation of interdigitating foot processes, replacement of tight junctions with slit diaphragms, and the concomitant opening of intercellular urinary spaces. It was postulated previously and confirmed recently that podocalyxin, a sialomucin, plays a major role in maintaining the urinary space open by virtue of the physicochemical properties of its highly negatively charged ectodomain. This study examined whether the highly conserved cytoplasmic tail of podocalyxin also contributes to the unique organization of podocytes by interacting with the cytoskeletal network found in their cell bodies and foot processes. By immunocytochemistry, it was shown that podocalyxin and the actin binding protein ezrin are co-expressed in podocytes and co-localize along the apical plasma membrane, where they form a co-immunoprecipitable complex. Selective detergent extraction followed by differential centrifugation revealed that some of the podocalyxin cosediments with actin filaments. Moreover, its sedimentation is dependent on polymerized actin and is mediated by complex formation with ezrin. Once formed, podocalyxin/ezrin complexes are very stable, because they are insensitive to actin depolymerization or inactivation of Rho kinase, which is known to be necessary for regulation of ezrin and to mediate Rho-dependent actin organization. These data indicate that in podocytes, podocalyxin is complexed with ezrin, which mediates its link to the actin cytoskeleton. Thus, in addition to its ectodomain, the cytoplasmic tail of podocalyxin also likely contributes to maintaining the unique podocyte morphology.
Impaired Function of Endothelial Pressure-Activated Cation Channel in Salt-Sensitive Genetic Hypertension
Authors: KO[Combining Diaeresis]HLER RALF , KREUTZ REINHOLD , GRUNDIG ALEXANDER , ROTHERMUND LARS , YAGIL CHANA , YAGIL YORAM , PRIES AXEL R. , HOYER JOACHIM 
Published: April 2021

Abstract.
Mechanosensitive ion channels have been suggested to act as endothelial mechanosensors for hemodynamic forces. The present study tested the hypothesis that the pressure-activated cation channel (PAC), a novel type of endothelial mechanosensitive ion channel, is involved in salt sensitivity in the Sabra rat model of hypertension. Groups of Sabra salt-sensitive (SBH/y) and salt-resistant (SBN/y) rats were loaded with deoxycorticosterone-acetate (DOCA)-salt for 8 wk or were fed a regular diet. Single channel function of PAC in SBH/y and SBN/y rats was investigated in intact endothelium of mesenteric artery using the patch-clamp technique. After DOCA-salt treatment, the SBH/y rats showed a full hypertensive response, whereas SBN/y rats were normotensive. Rats of both strains that received a regular diet were normotensive. In endothelium of both Sabra rats, Ca2+ permeable PAC that was activated by positive pipette pressures was identified. Apparent PAC density (percentage of patches with PAC activity) was reduced in hypertensive SBH/y rats that were loaded with DOCA-salt compared with salt-loaded normotensive SBN/y rats (6 ± 2% versus 24 ± 8%, respectively; P < 0.05). In normotensive SBH/y and SBN/y rats that received a regular diet, PAC density was not altered. Mechanosensitivity and unitary conductance of endothelial PAC were similar in both strains under a regular diet as well as salt loading with DOCA-salt. In conclusion, the decreased density of PAC in mesenteric endothelium from hypertensive SBH/y rats indicates an impaired ion channel regulation. The defective PAC function presumably leads to an impaired mechanosensitive Ca2+ entry and might contribute to endothelial dysfunction and high BP in this type of salt-sensitive genetic hypertension.