bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk
Authors: Fransquet P.D. , Lacaze P. , Saffery R. , Shah R.C. , Vryer R. , Murray A. , Woods R.L. , Ryan J. 
Published: August 2021

Background:
There is strong evidence that epigenetic age acceleration is associated
with increased risk of later-life diseases and all-cause mortality. However, there is currently limited
evidence that suggests accelerated epigenetic age is associated with dementia risk.

Objective:
This study aims to clarify whether epigenetic biomarkers of accelerated aging can predict
dementia risk, which is an important consideration as aging is the greatest risk factor for the
disease.

Methods:
DNA methylation was measured in peripheral blood samples provided by 160 participants
from the ASPirin in Reducing Events in the Elderly study, including 73 pre-symptomatic dementia
cases and 87 controls matched for age, sex, and smoking and education status. Epigenetic
age was calculated using Horvath, Hannum, GrimAge and PhenoAge DNA methylation clocks,
and age acceleration (the disparity between chronological age and epigenetic age) was determined.

Results:
There was no difference in age acceleration between dementia cases and controls. In
males, only Hannum’s intrinsic epigenetic age acceleration was increased in pre-symptomatic dementia
cases compared to controls (Δ +1.8 years, p = 0.03).

Conclusion:
These findings provide no strong evidence that accelerated epigenetic aging measured
in peripheral blood can predict dementia risk.
Atrial Fibrillation Recurrence Prevention after Electrical Cardioversion in High-Risk Patients – Benefits of Non-Antiarrhythmic Drugs
Authors: Kokina Baiba , Kalejs Oskars , Maca Aija , Strelnieks Aldis , Jubele Kristine , Rudaka Irina , Apsite Ketija , Lejnieks Aivars 
Published: August 2021

Background:
Recurrence prevention after Atrial Fibrillation (AF) termination by Eelectrical Cardioversion (ECV) remains challenging. Increasing attention is paid to pathophysiological effects of non-Antiarrhythmic Drugs (non-AADs), nevertheless, with heterogeneous results.

Objective:
We evaluated the potential benefits of different non-AADs as adjunctive therapy to Antiarrhythmic Drugs (AADs) for AF recurrence prevention after sinus rhythm restoration by ECV in high-risk patients.

Methods:
The study was conducted among high-risk AF patients after successful ECV. Prescription of class IC or class III AAD was required. Data were acquired in a face-to-face baseline interview and 1-, 3-, 6-, 9-, 12-month follow-up interviews.

Results:
113 patients were included. Total AF recurrence rate reached 48.7%. Angiotensin-Converting Enzyme Inhibitor (ACEI) or angiotensin receptor blocker (ARB) intake, compared with non-use, demonstrated AF recurrence rate reduction by 8.5% (46.3 vs. 54.8%), with odds ratio (OR) reduced by 28.9% (OR 0.711, 95% confidence interval (CI) 0.310-1.631, p = 0.420). Among mineralocorticoid receptor antagonist (MRA) users, AF recurrence rate was reduced by 25.1% (29.6 vs. 54.7%) and OR by 65.1% (OR 0.349, 95%CI 0.138-0.884, p = 0.023). Present statin therapy reduced AF recurrence rate by 4.2% (46.8 vs. 51.0%) and OR by 15.5% (OR 0.845, 95%CI 0.402-1.774, p = 0.656). Diuretic use showed reduction of AF recurrence rate by 10.2% (41.7 vs. 51.9%) and OR by 33.9% (OR 0.661, 95%CI 0.297-1.469, p = 0.308).

Conclusion:
Non-AADs demonstrated practical benefits as adjunctive therapy to AADs for AF recurrence prevention after ECV in high-risk patients, with statistically significant results established for concomitant MRA intake.
A Study on Opportunities for Augmented Reality in Future Business Models
Authors: S.Kamalasaravanan  
Published: August 2021

Augmented reality is actually an improved adaptation of reality where live immediate or aberrant perspectives of physical genuinesituations are increased with superimposed PC produced pictures over a client's perspective of this present reality, along the sidelinesupgrading one's present impression of reality.In Coimbatore total of 425,115 laborers, containing 1,539 cultivators, 2,908 essential cultivating specialists, 11,789 in householdbusiness ventures, 531 insignificant cultivators, and 20,877 other peripheral pros in Coimbatore. As a result of the research. Most people are known about augmented reality. They are aware of this technology in Coimbatore. From 150 samples, 97 majorities of peopleexperienced augmented reality before. So, the market is vast and whoever used it they are interested. It can be considered as a sign of hope.People liked it. 61.3 % of people liked it a lot and others actually didn't dislike it. So, it is also a good sign. Job holder’s people and studentsare highly involved in the application of augmented reality. They are mostly university-going students and highly proactive in technology.
DAMPAK PERTUMBUHAN EKONOMI, KONTROL KORUPSI, DAN YIELD TERHADAP INVESTASI ASING DI PASAR SUN
Authors: Rahmawati Wahyu Tri , Makaliwe Willem A. 
Published: August 2021

ABSTRACT

Foreign investment in debt securities in Indonesia continues to grow. Foreign investor ownership in Government Securities (SUN) reached 39% at the end of 2019 from initially only less than 1% at the end of 2002. Foreign investor hold the largest ownership in tradable Government Securities. This study discusses the push and pull factors of foreign portfolio in debt securities investment in emerging markets and Indonesia on the period of 2000-2017. This research uses quantitative methods with panel data analysis. The results showed that economic growth, corruption control, dan financial openness were the main pull factors for foreign investment in debt instruments in emerging markets. Low yield in developed countries was the push factor of foreign investment in debt securities into emerging markets. In addition to economic growth and corruption control, yield on local debt instruments attract foreign investment in debt securities in Indonesia. The results showed that the yield on local debt securities have a negative effect on foreign investment in Indonesian debt securities so that the government does not need to provide too high yield on Government Securities.
The Effect of Problem Based Learning (PBL) Charged Science Literacy Toward Students’ Learning Competences at XI Grade of SMAN 1 Lubuk Alung
Authors: Elmanazifa Sintia , Syamsurizal S. 
Published: August 2021

This research based on the problem on SMAN 1 Lubuk Alung, those are inappropriate learning model choices and low of students’ learning competencies. An efforts could done to solve it was implementation of problem based learning model charged with science literacy toward the students’ learning competencies on the topic of excretion system at XI grade of SMAN 1 Lubuk Alung. This research aimed to know the effects of Problem Based Learning (PBL) charged with science literacy toward the students’ learning competencies at XI grade of SMAN 1 Lubuk Alung. The type of this research was experimental research and designed on Control Group Posttest Only. The populations of this research were all of the students at grade XI MIPA of SMAN 1 Lubuk Alung academic years 2017/2018 that consisted of seven classes. This research used purposive sampling technique to take the samples; those are XI MIPA 3 as experiment group and XI MIPA 2 as control group. The research’s instruments used were test for cognitive competence and observation sheets for affective and psychomotor competence. Hypothesis was tested by using T-test method.Based on the thesis result by using t-test, it can be concluded that on students’ cognitive competence tscore 4,15> table 1,67, on students’ affective competence tscore 5,07 > table 1,67, and on students’ psychomotor competence tscore 1,69 > table 1,67. It showed that hypothesis was accepted. So it can be concluded that the implementation of Problem Based Learning (PBL) charged science literacy model improved toward students’ learning competences at XI grade of SMAN 1 Lubuk Alung significantly with 0,05 degrees of truthiness.
The Effect of the application of the Cooperative Learning Model Type Snowball Throwing Against an increase in the activity of learning to the learners on subjects Science in grade VII Inclusive SMPN 23 Padang
Authors: Khairani Eliza Octa , Ristiono Ristiono , Helendra Helendra , Fevria Resti 
Published: August 2021

The research was distributed by the low activity of learning to learners in an inclusive classroom while learning the IPA take place where student activity still centered on teachers so that students not actively in learning. This research aims to find out how big the influence of cooperative learning model type Snowball Throwing against learning activities learners in learning the IPA in the VII inclusive classroom junior high school 23 Padang. This type of research is the Quasy alphabets experiment using Control-Group design Only. This research was carried out in class VII2 as class experiments with the number of learners 32 people (with 3 learners ABK) and VII3 class as the class of the control to the number of learners 32 people (with 2 of HER students). The instruments used in the research in the form of the now learners learning activities that contains items of the statement drawn up in accordance with a predetermined indicators. Data analysis technique used is comparing the difference of two average learners with learning activities begins conducting a test of its homogeneity and normality, so that in the end done with test t (t-test).The average value of learning activities students class experiments is higher compared to the average value of learning activities learners class control. The average value of experimental class 76.41 and average value of kotrol class 70.08. Hypothesis test results data study activity learners class Sample thitung 2.67 and ttabel 1.67 its mean thitung > ttabel means then the hypothesis is accepted. This means that applying cooperative learning model type Snowball Throwing a positive effect against an increase in the activity of learning to the learners.
The Development of Student Worksheet Based on Contextual Approach about Protist for Senior High School Grade X
Authors: Dharmayanti Putri , Zulyusri Zulyusri , Farma Siska Aulia , Ristiono Ristiono 
Published: August 2021

The purpose of this research is to develop student worksheet based on Contextual Approach about Protist for SMA/MA. This research includes development research with reference to 4-D model. The experimental subject in this research is the subject of expert, namely two lecturers of Biology in State University of Padang and science teacher of National Junior High School of Sumpur, as well as the subject of grade X students of Sumpur SMA/MA as potential users of the product. Data in this research is primary data. Instrument collecting data used is validity sheet and sheet of practicality sheet by teacher and student. Result of validity is 86,2% with criteria is valid, result of practicality test is 87,5% by teacher with practical criteria and practice test by learner equal to 88% with practical criteria.
The Relationship Between Learning Styles and Biology Cognitive Competency of Senior High School Students
Authors: Meliyani Meliyani , Darussyamsu Rahmawati , Yogica Relsas , Sumarmin Ramadhan 
Published: August 2021

Learning styles are a combination of absorbing, regulating, and processing learning by students. There are three types of learning styles namely visual learning styles, auditory and kinesthetic. Based on the results of observations that the authors did at senior high school 7 Padang, it was revealed that the teacher still did not practice the relationship between the learning styles of students in their learning. This can lead to the learning styles are not synchronized with learning models, methods and media applied by teachers so that students' cognitive competency become low. The purpose of this study was to determine the relationship between learning styles and cognitive competency of students. This research is a descriptive research. This study uses a correlation study approach, namely the independent variable in the form of student learning styles and the dependent variable in the form of cognitive competency of students.To find out the relationship between variables stated with correlation coefficients used the Spearman-Rank correlation formula.Based on the research that has been done, it is found that the relationship between learning styles and cognitive competency of students does not mean and the correlation value is in the category of very weak to moderate. In the visual learning style for the second daily test there is a significant relationship and the correlation value is 0.75 with a strong correlation category. The conclusion of this study is that there is no significant relationship between learning styles and learners' cognitive competency.
The Effect of Model Two Stay Two Stray on Student Learnt Competencies on Ecosystem at Senior High School 4 Pariaman
Authors: Oktari Nengsih , Ristiono Ristiono , Zulyusri Zulyusri , Alberida Heffi 
Published: August 2021

This research aims to find out the effect of Two Stay Two stray model towards students' learning competencies, which still below from the average and there have no learning process that pursue the students to be active and creative until the students can increase their learning competencies; knowledge, attitude and skill in learning process. The research was quasi-experimental reserach with control group post-test only design. The population of this research was X IPA grade students that devided into five classes at SMAN 4 Pariaman in academic year 2018/2019. The sample was taken by purposive sampling technique which grade X IPA3 as the experimental group and grade X IPA1 as the control group. The result of this research showed the average score for grade X IPA3 was (75,43) for experimental group and (67,57) for control group in students' learning competencies. Then for behavioural competence the average score in experimental group was (84,21) and the control group reached (81,86) which the data was distributed normally and variant homogeneously. In hyphotesis testing was found by the formula tcount> ttable, learning competency (3,15 > 1,67), behavioural competency (1,76 > 1,67). Based on the result of the study, it can be concluded that the Two Stay Two Stray model give positive effect for the students' learning competencies in ecosystem at SMAN 4 Pariaman.
Effect of Biology Module with Scientific Approach Equipped with a Glossary in Discovery Learning models Against Learning Competencies of Class X Students of SMAN 1 Pariaman
Authors: Mar'i Husnul , Ristiono Ristiono , Rahmi Yosi Laila , Ahda Yuni 
Published: August 2021

This study is based on the problems that exist in SMAN 1 Pariaman, namely: textbooks that are used have not involved students playing an active role in learning, the learning model that is applied is still monotonous, student notebooks are incomplete and textbooks used in schools are not yet available examples -example/images according to the demands of Basic Competence to clarify the material description. Efforts can be made is the application of biological modules with a scientific approach equipped with a glossary in discovery learning models on the competencies of students in Class X of SMAN 1 Pariaman.The purpose of this study was to determine the effect of biological modules with a scientific approach equipped with a glossary in discovery learning models on the competencies of students in Class X of SMAN 1 Pariaman. This study was a quasi-experimental study with a randomized posttest control group design. The study population was tenth-grade students of SMAN 1 Pariaman 2018/2019 academic year consisting of seven classes. The research sample was taken using a purposive sampling technique, the results of which were selected Class X MIPA 2 as the experimental class and Class X MIPA 3 as the control class.The results of data analysis found that the knowledge competency data was normal and not homogeneous, competency data on attitudes, and homogeneous and normal student skills. Hypothesis test results are known that knowledge competencies (7.06>1.67), attitude competence (0.76<1.67), and skill competencies (0.925<1.67), so it can be concluded that the biological module with a scientific approach is equipped The glossary in discovery learning models has a positive influence on students 'knowledge competencies but does not have a positive influence on the competency of students' attitudes and skills at SMAN 1 Pariaman.
An Analysis of High Order Thinking Skills Aspects on the Assessment Instruments in Ecosyst Topic for the 10th Grade Senior High School Students
Authors: S Anisha , Hartanto Indra , Ahda Yuni , Darussyamsu Rahmawati 
Published: August 2021

This research is an description research which aims to see the influence of higher order thinking skills in biological learning at SMAN 1 Nan Sabaris. Higher order thinking skills are essential for student future. The future demands the existence of an evoluation instrument to train student higher order thingking, not only the thinking skill in the lower cognitive domain, but also in a higher domain. One of the efforts to enhance higher order thinking skills is to engage studenta with the question integrade by cognitive C4-C6. The research analysed aspect of higher order thinking in an evaluation instrument. Evaluatio9n instrument used by teachers at schools are still in the C1-C4 cognitive level (C1 17%, C2 35%, C3 26%, C4 22%), the evaluation instrument are not eligible according to the standart applied. The low cognitive level obtained in the evaluation instrument used by the teachers is the reason of the low thinking level of the student. Higher Order Thinking Skills, Evaluation Instrument
The Effect of the Assignment to Make a Mind Map Before the Implementation of Discovery Learning on the Knowledge Competencies of Class VII SMPN 2 Lubuk Alung
Authors: Putri Puput , Helendra Helendra , Selaras Ganda Hijrah , Ardi Ardi 
Published: August 2021

The research is based on the problems that exist in SMPN 2 Lubuk Alung, the students’ Cognitive competency are still low. One of the efforts that is done to increase students’ Cognitive competency is to apply the assigment to make a mind map before is applied the discovery learning on students VII grade learning competencies at SMPN 2 Lubuk Alung. This research used a randomized control group-only design. The population is all student of class VII SMPN 2 Lubuk Alung registered in 2018/2019. Sampel was taken by using purposive sampling technique and getting VII.1 as the eksperimen class, VII.2 as the control class. The hypothesis was tested using the t-test, can be concluded that the competence of learners knowledge tcount2,52>ttabel1,67. This shows that the hypothesis is accepted. it can be concluded that the assignment create a mind map before applying the discovery learning gives positive effect on students knowledge competencies the VII grade at SMPN 2 Lubuk Alung Keywords: Mind Map, Discovery Learning, Cognitive Competency
Peningkatan Apresiasi Sastra Melalui Teatrikal Puisi Bagi Siswa SMK Negeri 3 Banyumas
Authors: Nurdiyanto Erwita , Resticka Gita Anggria , Marahayu Nila Mega 
Published: August 2021

Bahasa merupakan alat komunikasi yang dapat dilakukan dengan bahasa lisan dan bahasa tulis. Puisi merupakan salah satu contoh interaksi yang diungkapkan secara fiksi. Unsur pembentuk puisi sama dengan genre sastra lainnya. Salah satu bentuk apresiasi sastra yaitu pembacaan puisi dengan unsur musikalitas dan ikonisitas yang memukau. Apresiasi sastra bukanlah merupakan keterampilan, melainkan seni atau kiat yang menekankan estetika dan penghargaan sastra. Kegiatan pengabdian masyarakat ini bekerja sama dengan sekolah SMK Negeri 3 Banyumas. Peserta kegiatan ini adalah siswa-siswi yang memiliki minat terhadap teater, khususnya yaitu ekstrakurikuker teater. Tujuan diadakannya kegiatan pengabdian ini yaitu meningkatkan apresiasi sastra siswa SMK Negeri 3 Banyumas melalui teatrikal puisi. Manfaat dari diadakannya kegiatan ini diharapkan para siswa dapat mengimplementasikan pada pertunjukkan teatrikal puisi lainnya. Luaran kegiatan berupa pementasan teatrikal pusi berjudul â€œIndonesia Tanah Air Mataâ€. Luaran dari kegiatan pengabdian diharapkan siswa SMK Negeri 3 Banyumas dapat meningkatkan kreativitasnya dalam mengapresiasi sastra yang tertuang dalam bentuk seni pertunjukkan.

A language is a communication tool that can be done with spoken and written languages. Poetry is one example of fictionally expressed interactions. The poetry-forming element is the same as other literary genres. One form of literary appreciation is the reading of poetry with elements of musicality and iconicity that amazes. Literary appreciation is not a skill, but rather an art or tip that emphasizes aesthetics and literary awards. This community service activity is in collaboration with Banyumas SMK Negeri 3 school. Participants of this activity are students who have an interest in theater, especially extracurricular theater. The purpose of this devotional activity is to increase the literary appreciation of students of SMK Negeri 3 Banyumas through theatrical poetry. The benefits of this activity are expected that students can implement other theatrical poetry performances. Outside the activity in the form of theatrical staging is titled "Indonesia Tanah Air Mata". Outside of the devotional activities, students of SMK Negeri 3 Banyumas are expected to increase their creativity in appreciating literature contained in the form of performing arts.
Yield Performance of Barley Hybrids (Hordeum vulgare L.) under Drought stress and non-stressed Conditions
Authors: Mahmood Yadgar , Nasraden Hassan Halgurd , Saber Mohammed Masood 
Published: August 2021

This study was carried out at the experiment field, Kalar Technical Institute, Garmian Region in two growing seasons of 2016-2017 and 2017-2018 in order to evaluate the growth and yield potentials of barley under water stressed using hybrids as a source of wide range of genotypic variations. Therefore, five F2 barley hybrids (Hordeum vulgare L.) were screened for grain yield, biomass dry matter, plant height and harvest index under irrigated and drought conditions. Results showed that there was no effect of drought on grain yield (P>0.05) in 2017, while significantly reduced yield in 2018 and across-year mean (P-2 (3//14) under irrigated condition, and 267.8 (3//5) to 302.3 g m-2 (3//4) under unirrigated condition (P=0.001), biomass dry matter was ranged from 1099.1 (3//1) to 1370.5 g m-2 (3//14) under irrigated condition, and 892.6 (3//1) to 1153.9 g m-2 (3//14) under unirrigated condition (P=0.05), and harvest index were from 25.1 (3//14) to 28.0 (3//1) under irrigated conditions, and 25.9 (3//14) to 31.2 (3//1) under unirrigated conditions (P=0.04). Regression analysis, averaging over years, showed a positive relationship between grain yield and biomass under irrigated (R2=0.76; P=0.05), despite that, any positive relation was not found under unirrigated conditions (R2=0.43; P=0.23) due to post-anthesis drought stress. A strong relationship was also found between plant height and biomass dry matter under both irrigated (R2=0.89; P=0.02) and unirrigated (R2=0.97; P=0.003) conditions due to the high contribution of plant height in increasing plant biomass. It is concluded that genotypes had different response to drought due to their genetic diversity, and relatively low impact of water stress was appeared on growth and grain yield of barley in this semi-arid region compared to worldwide expected range of yield reduction.