bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon Dot–Doped Titanium Dioxide Sheets for the Efficient Photocatalytic Performance of Refractory Pollutants
Authors: Shen Shen , Li Rong , Wang Hongbo , Fu Jiajia 
Published: September 2021

Broad solar light harvesting and fast photoinduced electron–hole migration are two critical factors for the catalytic capacity of photocatalytic system. In this study, novel visible light–driven carbon dot–TiO2 nanosheet (CD-TN) photocatalysts are successfully prepared by loading CDs on the surface of TNs through the hydrothermal method. The microstructure, chemical components, and optical properties of the prepared samples are characterized via X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, UV-visible diffuse reflectance spectroscopy, and X-ray photoelectron spectroscopy analysis. Congo red (CR), rhodamine B (RhB), and tetracycline (TC) are selected as pollutants to assess the catalytic performance of CD-TNs. As expected, the removal efficiencies of CD-TNs for CR, RhB, and TC are 94.6% (120 min), 97.2% (150 min), and 96.1% (60 min), respectively, obviously higher than that of pure TNs. The enhanced degradation efficiency of CD-TNs is predominantly ascribed to the merits of CDs (excellent up-conversion property and electron transfer property). Moreover, according to the several degradation cycles, CD-TNs possess the excellent stability, having removed 93.3% of CR after 120 min irradiation.
Preparation of Furfural From Xylose Catalyzed by Diimidazole Hexafluorophosphate in Microwave
Authors: Huang Ting , Yuan Kun , Nie Xu-Liang , Chen Jing , Zhang Huang-Xian , Chen Jin-Zhu , Xiong Wan-Ming 
Published: September 2021

In this work, functionalized alkyl imidazolium hexafluorophosphate ILs were synthesized and characterized; then, they were applied in the conversion of xylose to furfural under the microwave method. The results showed that when CnMF was used as a catalyst, an acidic environment was provided to promote the formation of furfural. In addition, the heating method, the solvent, and the different structures of cations in the ionic liquid influenced their catalytic activity. In an aqueous solution, the yield of furfural obtained using the microwave method was better than that of the conventional heating method, and the catalytic activity of diimidazole hexafluorophosphate was better than that of monoimidazole. Meanwhile, for the diimidazole hexafluorophosphate, the change of the carbon chain length between the imidazole rings also slightly influenced the yield. Finally, the optimal yield of 49.76% was obtained at 205°C for 8 min using 3,3′-methylenebis(1-methyl-1H-imidazol-3-ium), C1MF, as a catalyst. Mechanistic studies suggested that the catalytic activity of C1MF was mainly due to the combined effect of POFn (OH)3-n and imidazole ring. Without a doubt, the catalytic activity of C1MF was still available after five cycles, which not only showed its excellent catalytic activity in catalyzing the xylose to prepare the biomass platform compound furfural but also could promote the application of functionalized ionic liquids.
An Active Catalyst System Based on Pd (0) and a Phosphine-Based Bulky Ligand for the Synthesis of Thiophene-Containing Conjugated Polymers
Authors: Liu Meifang , Liu Li , Zhang Zhihui , Wan Meixiu , Guo Huanmei , Li Dan 
Published: September 2021

To address the limitations of conventional Pd catalysts in the polymerization of thiophene-containing conjugated polymers, an active catalyst system based on Pd (0) and a phosphine-based bulky ligand, L1, is explored systematically in Suzuki–Miyaura polymerizations using thiophene boronic acid pinacol ester as one of the monomers. This active catalyst is found very efficient in synthesizing a series of thiophene-containing linear and hyperbranched conjugated polymers. First, as a model example, coupling reactions between electron-rich/moderately hindered aryl or thienyl halides and thiophene boronic acid pinacol ester give excellent yields with lower catalyst loading and can be completed in a shorter reaction time relative to Pd(PPh3)4. Notably, high molecular weight thiophene-containing polymers are successfully synthesized by Suzuki–Miyaura polycondensation of 2,5-thiophene bis(boronic acid) derivatives with different dibromo- and triple bromo-substituted aromatics in 5–15 min.
Conservation and Identity Selection of Cationic Residues Flanking the Hydrophobic Regions in Intermediate Filament Superfamily
Authors: Zhang Wenbo , Liu Mingwei , Dupont Robert L. , Huang Kai , Yu Lanlan , Liu Shuli , Wang Xiaoguang , Wang Chenxuan 
Published: September 2021

The interplay between the hydrophobic interactions generated by the nonpolar region and the proximal functional groups within nanometers of the nonpolar region offers a promising strategy to manipulate the intermolecular hydrophobic attractions in an artificial molecule system, but the outcomes of such modulations in the building of a native protein architecture remain unclear. Here we focus on the intermediate filament (IF) coiled-coil superfamily to assess the conservation of positively charged residue identity via a biostatistical approach. By screening the disease-correlated mutations throughout the IF superfamily, 10 distinct hotspots where a cation-to-cation substitution is associated with a pathogenic syndrome have been identified. The analysis of the local chemical context surrounding the hotspots revealed that the cationic diversity depends on their separation distance to the hydrophobic domain. The nearby cationic residues flanking the hydrophobic domain of a helix (separation &lt;1 nm) are relatively conserved in evolution. In contrast, the cationic residues that are not adjacent to the hydrophobic domain (separation &gt;1 nm) tolerate higher levels of variation and replaceability. We attribute this bias in the conservation degree of the cationic residue identity to reflect the interplay between the proximal cations and the hydrophobic interactions.
Gut Lactobacillus Level Is a Predictive Marker for Coronary Atherosclerotic Lesions Progress and Prognosis in Patients With Acute Coronary Syndrome
Authors: Gao Jing , Wang Jie , Zhao Li-Li , Yao Ting-Ting , Chen Yang , Ma Jing , Zhang Xu , Wang Jing-Xian , Wang Yuan , Cui Zhuang , Liu Yin 
Published: September 2021

BackgroundGut microbiota dysbiosis can contribute to the progression of atherosclerosis. We investigated the association of the gut microbiota and the severity of coronary artery lesions and prognosis of patients with ACS.MethodsIn this case-control study, 402 ACS patients and 100 controls were enrolled from June 2017 to December 2018. The number of bacterial species was determined by real-time PCR. A SYNTAX score was calculated for all ACS patients based on their coronary angiography results.ResultsCompared with the healthy controls, the gut microbial levels in Escherichia coli, Streptococcus, and Enterobacteriaceae were significantly increased in ACS patients, while the Lactobacillus level was significantly decreased. Lactobacillus level was as an independent predictor of disease severity on the coronary angiography [high vs. low SYNTAX score: adjusted odds ratio (aOR) = 0.024, 95% confidence interval (CI): 0.004–0.155] and myocardial necrosis [high vs. low cardiac troponin T (cTNT): aOR = 0.317, 95% CI: 0.099–0.914]. Subsequently, a higher Lactobacillus level was associated with a lower risk of an all-cause death [adjusted hazard ratio (aHR) = 0.239; 95% CI: 0.093–0.617] and major adverse cardiac events (MACE) in ACS patients (aHR = 0.208; 95% CI: 0.081–0.531). After stratifying by the type of ACS, a higher Lactobacillus level was significantly associated with the decreased risks of high SYNTAX score, all-cause death, and MACE in the STEMI subgroup but not in the NSTEMI and UAP subgroups.ConclusionsLower Lactobacillus levels may indicate a higher risk of a more severe coronary atherosclerotic lesions and myocardial necrosis and worse prognosis for patients with ACS, particularly in the STEMI subgroup.
Understanding the Experiences of Remote Workers: Opportunities for Ambient Workspaces at Home
Authors: Margariti Eleni Kallopi , Ali Ridita , Benthem de Grave Remco , Verweij David , Smeddinck Jan , Kirk David 
Published: September 2021

As the COVID-19 pandemic has forced many to work remotely from home, collaborating solely through digital technologies, a growing population of remote home workers are faced with profound wellbeing challenges. Passive sensing devices and ambient feedback have great potential to support the wellbeing of the remote workers, but there is a lack of background and understanding of the domestic workplace in terms of physical and affective dimensions and challenges to wellbeing. There are profound research gaps on wellbeing in the domestic workplace, with the current push for remote home and hybrid working making this topic timely. To address these gaps and shape a starting point for an “ambient workspaces” agenda, we conducted an exploratory study to map physical and affective aspects of working from home. The study involved both qualitative and quantitative measures of occupant experience, including sensor wristbands, and a custom web application for self-reporting mood and aspects of the environment. It included 13 participants for a period of 4 weeks, during a period of exclusive home working. Based on quantitative and qualitative analysis, our study addresses wellbeing challenges of the domestic workplace, establishes correlations between mood and physical aspects, and discusses the impact of feedback mechanisms in the domestic workplace on the behavior of remote workers. Insights from these observations are then used to inform a future design agenda for ambient technologies that supports the wellbeing of remote workers; addressing the design opportunities for ambient interventions in domestic workspaces. This work offers three contributions: 1) qualitatively and quantitatively informed understandings of the experiences of home-workers; 2) a future design agenda for “ambient home workspaces”; and 3) we propose three design concepts for ambient feedback and human–AI interactions in the built environment, to illustrate the utility of the design agenda.
Intermediate- and Deep-Water Oxygenation History in the Subarctic North Pacific During the Last Deglacial Period
Authors: Ovsepyan Ekaterina , Ivanova Elena , Tetard Martin , Max Lars , Tiedemann Ralf 
Published: September 2021

Deglacial dissolved oxygen concentrations were semiquantitatively estimated for intermediate and deep waters in the western Bering Sea using the benthic foraminiferal-based transfer function developed by Tetard et al. (2017), Tetard et al. (2021a). Benthic foraminiferal assemblages were analyzed from two sediment cores, SO201-2-85KL (963 m below sea level (mbsl), the intermediate-water core) and SO201-2-77KL (2,163 mbsl, the deep-water core), collected from the Shirshov Ridge in the western Bering Sea. Intermediate waters were characterized by an oxygen content of ∼2.0 ml L−1 or more during the Last Glacial Maximum (LGM)–Heinrich 1 (H1), around 0.15 ml L−1 during the middle Bølling/Allerød (B/A)–Early Holocene (EH), and a slight increase in [O2] (∼0.20 ml L−1) at the beginning of the Younger Dryas (YD) mbsl. Deep-water oxygen concentrations ranged from 0.9 to 2.5 ml L−1 during the LGM–H1, hovered around 0.08 ml L−1 at the onset of B/A, and were within the 0.30–0.85 ml L−1 range from the middle B/A to the first half of YD and the 1.0–1.7 ml L−1 range from the middle to late Holocene. The [O2] variations remind the δ18O NGRIP record thereby providing evidence for a link between the Bering Sea oxygenation at intermediate depths and the deglacial North Atlantic climate. Changes in the deep-water oxygen concentrations mostly resemble the deglacial dynamics of the Southern Ocean upwelling intensity which is supposed to be closely coupled with the Antarctic climate variability. This coherence suggests that deglacial deep-water [O2] variations were primarily controlled by changes in the circulation of southern-sourced waters. Nevertheless, the signal from the south at the deeper site might be amplified by the Northern Hemisphere climate warming via an increase in sea-surface bioproductivity during the B/A and EH. A semi-enclosed position of the Bering Sea and sea-level oscillations might significantly contribute to the magnitude of oxygenation changes in the study area during the last deglaciation. Interregional correlation of different proxy data from a wide range of water depths indicates that deglacial oxygenation changes were more pronounced in the Bering and Okhotsk marginal seas than along the open-ocean continental margin and abyssal settings of the North Pacific.
The Effect of Formation Water Salinity on the Minimum Miscibility Pressure of CO2-Crude Oil for Y Oilfield
Authors: Pi Yanfu , Liu Jinxin , Liu Li , Guo Xuan , Li Chengliang , Li Zhihao 
Published: September 2021

CO2 miscible flooding is an important technology for enhancing oil recovery and greenhouse gas storage in the world. As a tertiary recovery technology, it is usually applied after water flooding. Therefore, the actual reservoirs usually contain a lot of injected water in addition to connate water. The salinity of these formation waters varies from place to place. CO2 is an acid gas. After it is injected into the reservoir, it easily reacts with formation water and rock and affects the physical properties of the reservoir. However, no research results have been reported whether this reaction affects the minimum miscibility pressure (MMP) of CO2-crude oil, a key parameter determining miscible flooding in formation water. Based on CO2-formation water–rock interaction experiments, this paper uses the core flooding method to measure the CO2-crude oil MMP under different salinity in formation water. Results show that CO2 causes a formation water pH decrease from 7.4 to 6.5 due to its dissolution in formation water. At the same time, CO2 reacts with formation water, albite, potassium feldspar, and carbonate minerals in the cores to generate silicate and carbonate precipitates, which could migrate to the pore throat together with the released clay particles. Overall, CO2 increased core porosity by 5.63% and reduced core permeability by 7.43%. In addition, when the salinity of formation water in cores was 0, 4,767, and 6,778 mg/L, the MMP of CO2-crude oil was 20.58, 19.85, and 19.32 MPa, respectively. In other words, the MMP of CO2-crude oil decreased with the increase of salinity of formation water.
An Operational Earthquake Forecasting Experiment for Israel: Preliminary Results
Authors: Falcone Giuseppe , Spassiani Ilaria , Ashkenazy Yosef , Shapira Avi , Hofstetter Rami , Havlin Shlomo , Marzocchi Warner 
Published: September 2021

Operational Earthquake Forecasting (OEF) aims to deliver timely and reliable forecasts that may help to mitigate seismic risk during earthquake sequences. In this paper, we build the first OEF system for the State of Israel, and we evaluate its reliability. This first version of the OEF system is composed of one forecasting model, which is based on a stochastic clustering Epidemic Type Earthquake Sequence (ETES) model. For every day of the forecasting time period, January 1, 2016 - November 15, 2020, the OEF-Israel system produces a weekly forecast for target earthquakes with local magnitudes greater than 4.0 and 5.5 in the entire State of Israel. Specifically, it provides space-time-dependent seismic maps of the weekly probabilities, obtained by using a fixed set of the model’s parameters, which are estimated through the maximum likelihood technique based on a learning period of about 32 years (1983–2015). According to the guidance proposed by the Collaboratory for the Study of Earthquake Predictability (CSEP), we also perform the N- and S-statistical tests to verify the reliability of the forecasts. Results show that the OEF system forecasts a number of events comparable to the observed one, and also captures quite well the spatial distribution of the real catalog with the exception of two target events that occurred in low seismicity regions.
Enhanced Quaternary Exhumation in the Central Three Rivers Region, Southeastern Tibet
Authors: Shen Xiaoming , Tian Yuntao , Wang Ying , Wu Lin , Jia Yingying , Tang Xiudang , Lei Haijia , Yuan Xiaoping , Ge Yukui , Liu-Zeng Jing 
Published: September 2021

The roles of tectonics and climate in the global increased erosion rates during the Quaternary have been the subject of active debate. The Three Rivers Region, strongly influenced by continental convergence between India and Eurasia and change in Asian monsoon climate, is an ideal place to study the interactions between tectonics and surface processes. Here we report new apatite (U-Th)/He data from an elevation transect that reveal a phase of rapid exhumation since ∼2.6 Ma in the Dulong batholith in the central Three Rivers Region, southeastern Tibetan Plateau. Based on stream profile analysis and compiled thermochronological data in the region, we demonstrate that the tectonic uplift caused by the high-strain at the corner of Indian-Eurasia convergence is responsible for the enhanced exhumation in the central Three Rivers Region in the Quaternary. Our new results highlight that the continuous plate convergence towards the plateau interior has dominated the uplift and deformation in the southeastern Tibet in the Quaternary.
Program Design Principles to Support Teen-Adult Community Conservation Efforts
Authors: Cisneros Laura M. , Simmons Jonathan , Campbell Todd , Freidenfelds Nicole , Arnold Chester , Chadwick Cary , Dickson David , Moss David , Rodriguez Laura , Volin John C. 
Published: September 2021

Researchers and practitioners have identified numerous outcomes of place-based environmental action (PBEA) programs at both individual and community levels (e.g., promoting positive youth development, fostering science identity, building social capital, and contributing to environmental quality improvement). In many cases, the primary audience of PBEA programs are youth, with less attention given to lifelong learners or intergenerational (e.g., youth and adult) partnerships. However, there is a need for PBEA programs for lifelong learners as local conservation decisions in the United States are often carried out by volunteer boards and commissions, which often have little formal conservation training. Intergenerational PBEA programs can provide an opportunity to bring together, in the case of this study, the unique skills and knowledge of teens (e.g., tech-savvy) and adults (e.g., knowledgeable of local community issues) that can lead to innovative ways of addressing real world endeavors that are relevant to participants and their communities.This study describes a program model that offers structured learning opportunities that support intergenerational partnerships (teens and adults) as they contribute to community conservation efforts. We used a design-based research approach to develop and refine program design principles and communication pillars for the purpose of supporting successful teen-adult conservation projects, positive participant experiences, and science identity authoring. The principles and pillars drew on identity, cultural learning pathways, and community conservation research literature as well as previously collected participant interview data from our intergenerational PBEA program. We outline four design principles and four communication pillars that are critical to facilitate collaborative teen-adult environmental action efforts and serve dual functions of providing program guidance and participant support. The aim of these principles and pillars are to establish collaborative team partnership norms that resist traditional hierarchical teen-adult relationships. Further, the principles and pillars consider how partners can draw on their interests, experiences, and knowledge of community, and utilize these assets along with conservation science disciplinary practices to accomplish meaningful science pursuits; thus facilitating how they identify themselves as contributing to science endeavors. Exemplar data and literature that support each principle and pillar are provided, and future extensions of these principles are discussed.
Computational Design of an Integrated CMOS Readout Circuit for Sensing With Organic Field-Effect Transistors
Authors: Taheri H. Esmaeili , Ocheje Michael U. , St. Onge P. Blake J. , Rondeau-Gagné Simon , Mirhassani Mitra 
Published: September 2021

Organic field-effect transistors (OFETs) are at the forefront of next generation electronics. This class of devices is particularly promising due to the possibility of fabrication on mechanically compliant and conformable substrates, and potential manufacturing at large scale through solution deposition techniques. However, their integration in circuits, especially using stretchable materials, is still challenging. In this work, the design and implementation of a novel structure for an integrated CMOS readout circuitry is presented and its fundamentals of operation are provided. Critical for sensing applications, the readout circuitry described is highly linear. Moreover, as several sources of mismatch and error are present in CMOS and OFET devices, a calibration technique is used to cancel out all the mismatches, thus delivering a reliable output. The readout circuit is verified in TSMC 0.18 μm CMOS technology. The maximum total power consumption in the proposed readout circuit is less than 571 μW, while fully loaded calibration circuit consumes a power less than 153 μW, making it suitable for sensors applications. Based on previously reported high mobility and stretchable semiconducting polymers, this new design and readout circuitry is an important step toward a broader utilization of OFETs and the design of stretchable sensors.
Plasma Metabolome Profiling for the Diagnosis of Catecholamine Producing Tumors
Authors: März Juliane , Kurlbaum Max , Roche-Lancaster Oisin , Deutschbein Timo , Peitzsch Mirko , Prehn Cornelia , Weismann Dirk , Robledo Mercedes , Adamski Jerzy , Fassnacht Martin , Kunz Meik , Kroiss Matthias 
Published: September 2021

ContextPheochromocytomas and paragangliomas (PPGL) cause catecholamine excess leading to a characteristic clinical phenotype. Intra-individual changes at metabolome level have been described after surgical PPGL removal. The value of metabolomics for the diagnosis of PPGL has not been studied yet.ObjectiveEvaluation of quantitative metabolomics as a diagnostic tool for PPGL.DesignTargeted metabolomics by liquid chromatography-tandem mass spectrometry of plasma specimens and statistical modeling using ML-based feature selection approaches in a clinically well characterized cohort study.PatientsProspectively enrolled patients (n=36, 17 female) from the Prospective Monoamine-producing Tumor Study (PMT) with hormonally active PPGL and 36 matched controls in whom PPGL was rigorously excluded.ResultsAmong 188 measured metabolites, only without considering false discovery rate, 4 exhibited statistically significant differences between patients with PPGL and controls (histidine p=0.004, threonine p=0.008, lyso PC a C28:0 p=0.044, sum of hexoses p=0.018). Weak, but significant correlations for histidine, threonine and lyso PC a C28:0 with total urine catecholamine levels were identified. Only the sum of hexoses (reflecting glucose) showed significant correlations with plasma metanephrines.By using ML-based feature selection approaches, we identified diagnostic signatures which all exhibited low accuracy and sensitivity. The best predictive value (sensitivity 87.5%, accuracy 67.3%) was obtained by using Gradient Boosting Machine Modelling.ConclusionsThe diabetogenic effect of catecholamine excess dominates the plasma metabolome in PPGL patients. While curative surgery for PPGL led to normalization of catecholamine-induced alterations of metabolomics in individual patients, plasma metabolomics are not useful for diagnostic purposes, most likely due to inter-individual variability.