bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment for the Benign Childhood Epilepsy With Centrotemporal Spikes: A Monocentric Study
Authors: Kessi Miriam , Yan Fangling , Pan Langui , Chen Baiyu , Olatoutou Eleonore , Li Dong , He Fang , Rugambwa Tibera , Yang Lifen , Peng Jing , Yin Fei 
Published: May 2021

Background and Purpose: To date, there is no specific treatment guideline for the benign childhood epilepsy with centrotemporal spikes (BECTS). Several countries recommend levetiracetam, carbamazepine, sodium valproate, oxcarbazepine, and lamotrigine as first-line drugs. Nevertheless, some of these drugs are associated with cognitive decline. Available studies that investigated the efficacy of levetiracetam and sodium valproate on BECTS involved small sample sizes. This study aimed to evaluate the efficacy of levetiracetam and sodium valproate on cognition, and to investigate the prognostic factors for BECTS as whole.Methods: Clinical data and treatment status of all patients with BECTS at Xiangya Hospital, Central South University followed from 2008 to 2013 were analyzed retrospectively. Since electrical status epilepticus in sleep (ESES) has been confirmed to play a role in cognitive deterioration, in order to evaluate the response to drugs and their cognitive effects, we created two groups of patients according to the levels of spike wave index (SWI): group 1; 0–50% SWI and group 2; &gt;50% SWI at the last follow up.Results: A total of 195 cases were enrolled: 49.7% received monotherapies, 24.1% duotherapies and 27.2% polytherapies. Medications included; levetiracetam plus other drug (s) (75.9%), levetiracetam alone (32.8%), sodium valproate plus other drug (s) (31.3%), and sodium valproate alone (5.1%). After 2 years of treatment and follow up, 71% of the cases had a good seizure outcome, 15.9% had an improvement of SWI, and 91.7% had a normal DQ/IQ. Sodium valproate combined with levetiracetam, and sodium valproate alone correlated with good improvement of SWI, whereas, focal spikes were linked with poor improvement. For both groups (group 1 and group 2): monotherapy, levetiracetam alone, and a normal DQ/IQ at seizure onset correlated with good cognitive outcomes, in contrast, polytherapy, sodium valproate plus other drug (s), levetiracetam plus sodium valproate, an initial SWI of ≥85%, and multifocal spikes were linked to cognitive deterioration.Conclusions: Monotherapy, particularly levetiracetam seems to be a good first-line therapy which can help in normalizing the electroencephalograph and preventing cognitive decline. Polytherapy, mostly the administration of sodium valproate seems to relate with poor cognition, therefore, it is recommended to avoid it.
Characterization of Plasma Cell-Free DNA Integrity Using Droplet-Based Digital PCR: Toward the Development of Circulating Tumor DNA-Dedicated Assays
Authors: Poulet Geoffroy , Garlan Fanny , Garrigou Sonia , Zonta Eleonora , Benhaim Leonor , Carrillon Marie-Jennifer , Didelot Audrey , Le Corre Delphine , Mulot Claire , Nizard Philippe , Ginot Frederic , Boutonnet-Rodat Audrey , Blons Helene , Bachet Jean-Baptiste , Taïeb Julien , Zaanan Aziz , Geromel Vanna , Pellegrina Laurence , Laurent-Puig Pierre , Wang-Renault Shu-Fang , Taly Valerie 
Published: May 2021

Background: Cellular-cell free-DNA (ccfDNA) is being explored as a diagnostic and prognostic tool for various diseases including cancer. Beyond the evaluation of the ccfDNA mutational status, its fragmentation has been investigated as a potential cancer biomarker in several studies. However, probably due to a lack of standardized procedures dedicated to preanalytical and analytical processing of plasma samples, contradictory results have been published.Methods: ddPCR assays allowing the detection of KRAS wild-type and mutated sequences (KRAS p.G12V, pG12D, and pG13D) were designed to target different fragments sizes. Once validated on fragmented and non-fragmented DNA extracted from cancer cell lines, these assays were used to investigate the influence of the extraction methods on the non-mutated and mutated ccfDNA integrity reflected by the DNA integrity index (DII). The DII was then analyzed in two prospective cohorts of metastatic colorectal cancer patients (RASANC study n = 34; PLACOL study n = 12) and healthy subjects (n = 49).Results and Discussion: Our results demonstrate that ccfDNA is highly fragmented in mCRC patients compared with healthy individuals. These results strongly suggest that the characterization of ccfDNA integrity hold great promise toward the development of a universal biomarker for the follow-up of mCRC patients. Furthermore, they support the importance of standardization of sample handling and processing in such analysis.
Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice
Authors: Adu-Nti Frank , Gao Xu , Wu Jia-Min , Li Jing , Iqbal Javed , Ahmad Riaz , Ma Xin-Ming 
Published: May 2021

Loss of endogenous estrogen and dysregulation of the estrogen receptor signaling pathways are associated with an increase in risk for cognitive deficit and depression in women after menopause. Estrogen therapy for menopause increases the risk of breast and ovarian cancers, and stroke. Therefore, it is critical to find an alternate treatment for menopausal women. Osthole (OST), a coumarin, has been reported to have neuroprotective effects. This study examined whether OST improves ovariectomy (OVX)-induced cognitive impairment, and alleviates anxiety- and depression-like behaviors induced by OVX in mice. Adult female C57BL/6J mice were ovariectomized and then treated with OST at a dose of 30 mg/kg for 14 days. At the end of the treatment period, behavioral tests were used to evaluate spatial learning and memory, recognition memory, anxiety- and depression-like behaviors. A cohort of the mice were sacrificed after 14 days of OST treatment and their hippocampi were collected for measurement of the proteins of interest using western blot. OVX-induced alteration in the levels of proteins was accompanied by cognitive deficit, anxiety- and depression-like behaviors. OST treatment improved cognitive deficit, alleviated anxiety- and depression-like behaviors induced by OVX, and reversed OVX-induced alterations in the levels of synaptic proteins and ERα, BDNF, TrKB, p-CREB, p-Akt and Rac1 in the hippocampus. Therefore, reversal of OVX-induced decrease in the levels of hippocampal proteins by OST might contribute to the effects of OST on improving cognitive deficit and alleviating anxiety- and depression-like behaviors induced by OVX.
Depression and Creativity During COVID-19: Psychological Resilience as a Mediator and Deliberate Rumination as a Moderator
Authors: Xu Yanhua , Shao Jinlian , Zeng Wei , Wu Xingrou , Huang Dongtao , Zeng Yuqing , Wu Jiamin 
Published: May 2021

Purpose:The pandemic of coronavirus disease 2019 (COVID-19), which has had a significant impact on people’s lives, has apparently increased the incidence of depression. Although the topic of how depression affects creativity is contested, previous research has revealed a significant relationship between the two. The purpose of this study is to further investigate the relationship and the mechanisms that operate between depression and creativity.Methods:A total of 881 students at an independent college in China completed a questionnaire consisting of the Self-Reported Depression Scale, Runco Ideational Behavior Scale, Psychological Resilience Scale, Deliberate Rumination Scale and demographic information. Among the respondents, 317 (36.0%) were male and 564 (64.0%) were female, all of whom were from the same grade. Correlation analyses were conducted, and then the researchers carried out mediation analysis and developed a moderated mediation model.Results:The results indicated that (a) depression was positively related to creativity (r= 0.085,p&lt; 0.05); (b) psychological resilience mediated the relationship between depression and creativity; specifically, psychological resilience was negatively related to depression (r= −0.462,p&lt; 0.01), which in turn was positively related to creativity (r= 0.198,p&lt; 0.01); and (c) deliberate rumination moderated the relationship between depression and psychological resilience, showing a significant negative correlation with depression (r= 0.138,p&lt; 0.01), psychological resilience (r= 0.078,p&lt; 0.05), and creativity (r= 0.288,p&lt; 0.05); specifically, higher levels of deliberate rumination strengthened the negative correlation between psychological resilience and depression.Conclusion:The results suggest that depression is a positive predictor of creativity and may promote creativity to some extent. Further, individuals with greater psychological resilience are more creative than those with less psychological resilience, as it is a question of whether they can and to what extent they can effectively use depression as an emotional resource. Last, an individual’s level of deliberate rumination moderates the mediating process, especially at the stage where depression is associated with psychological resilience. These findings advance understanding of the mechanisms that operate between depression and creativity.
Sucesso escolar e desigualdade social: o poder do capital subjetivo
Authors: Morgan de Aguiar Neto Jorge 
Published: May 2021

Este artigo destaca as contribuições de Pierre Bourdieu e Jean-Claude Passeron que constituem o ponto de partida para problematizarmos a maneira como a desigualdade social e cultural repercute no meio universitário brasileiro. O artigo está dividido em três partes. Na primeira, discutimos as reflexões dos autores sobre a reprodução das estruturas sociais e culturais na escola e na universidade, bem como a articulação dos conceitos habitus e campo, que ajudam a demarcar o objeto da pesquisa. Na segunda, fazemos um contraponto aos primeiros autores com base no trabalho de Bernard Lahire, que desenvolve a teoria do homem plural tendo como foco conceitos de Bourdieu e a análise do sucesso escolar. Finalmente, confrontamos essas reflexões com os dados obtidos através de uma pesquisa qualitativa, realizada junto a estudantes de origem popular que, oriundos da escola pública, conseguiram ascender ao ensino superior e se encontram matriculados em cursos de prestígio. Ao buscar contribuir para a compreensão de como se configura o sucesso escolar entre os grupos de jovens desfavorecidos, nosso trabalho traz elementos que podem servir como referência para o desenvolvimento de políticas públicas de educação duradouras, inclusivas e consequentes.
Outcomes among Hospitalized Chronic Kidney Disease Patients with COVID-19
Authors: Khatri Minesh , Charytan David M. , Parnia Sam , Petrilli Christopher M. , Michael Jeffrey , Liu David , Tatapudi Vasishta , Jones Simon , Benstein Judith , Horwitz Leora I. 
Published: May 2021

Abstract

Key Points

Patients with ESKD had higher crude mortality rates than those without CKD, but thiswas no longer significant after multivariate adjustment.Patients with ESKD, when directly compared with those with nondialysis CKD, appeared to have reduced risk of mortality, despite adjusting for confounders.Mortality associated with coronavirus disease 2019 declined significantly during the pandemic, and initial reports likely overestimate mortality rates among patients with CKD.

Background
Patients with CKD ha ve impaired immunity, increased risk of infection-related mortality, and worsened COVID-19 outcomes. However, data comparing nondialysis CKD and ESKD are sparse.

Methods
Patients with COVID-19 admitted to three hospitals in the New York area, between March 2 and August 27, 2020, were retrospectively studied using electronic health records. Patients were classified as those without CKD, those with nondialysis CKD, and those with ESKD, with outcomes including hospital mortality, ICU admission, and mortality rates.

Results
Of 3905 patients, 588 (15%) had nondialysis CKD and 128 (3%) had ESKD. The nondialysis CKD and ESKD groups had a greater prevalence of comorbidities and higher admission D-dimer levels, whereas patients with ESKD had lower C-reactive protein levels at admission. ICU admission rates were similar across all three groups (23%–25%). The overall, unadjusted hospital mortality was 25%, and the mortality was 24% for those without CKD, 34% for those with nondialysis CKD, and 27% for those with ESKD. Among patients in the ICU, mortality was 56%, 64%, and 56%, respectively. Although patients with nondialysis CKD had higher odds of overall mortality versus those without CKD in univariate analysis (OR, 1.58; 95% CI, 1.31 to 1.91), this was no longer significant in fully adjusted models (OR, 1.11; 95% CI, 0.88 to 1.40). Also, ESKD status did not associate with a higher risk of mortality compared with non-CKD in adjusted analyses, but did have reduced mortality when compared with nondialysis CKD (OR, 0.57; 95% CI, 0.33 to 0.95). Mortality rates declined precipitously after the first 2 months of the pandemic, from 26% to 14%, which was reflected in all three subgroups.

Conclusions
In a diverse cohort of patients with COVID-19, we observed higher crude mortality rates for patients with nondialysis CKD and, to a lesser extent, ESKD, which were not significant after risk adjustment. Moreover, patients with ESKD appear to have better outcom es than those with nondialysis CKD.
EFEKTIVITAS PELAYANAN TRANSPORTASI PUBLIK BUS DAMRI ANGKUTAN PEMADU MODA RUTE MOJOKERTO-BANDARA JUANDA
Authors: Hertati Diana , Vandayani Dynda Safitri , Shalsabila Ainy Dewi Fortuna , Salam Monica Dwipi 
Published: May 2021

Pelayanan transportasi publik merupakan sarana pelayanan yang memiliki posisi penting dan strategis dalam pembangunan nasional. Sehingga perlu dilakukan perencanaan dan pengembangan melalui penataan dalam suatu sistem yang terpadu dengan memberikan pelayanan kepada masyarakat. Pemerintah Kota Mojokerto dalam mendukung terciptanya pelayanan transportasi publik, ikut serta membantu mendukung pengembangan angkutan pemadu moda Bus Damri yang dibuat oleh Perum DAMRI Cabang Surabaya. Pada tanggal 21 Maret 2020, Pemerintah Kota Mojokerto meresmikan Angkutan Pemandu Moda (Damri) rute Kota Mojokerto–Bandara Juanda. Namun dalam kurun waktu satu tahun setelah diresmikan, ditemukan fakta bahwa bus DAMRI ini masih kurang diminati. Tujuan dari penelitian ini adalah untuk menjawab secara empiris efektivitas pelayanan Pemandu Moda Bus Damri rute Mojokerto-Bandara Juanda sebagai pelayanan transportasi publik . Penelitian ini menggunakan metode observasi dan wawancara langsung ke lapangan dengan pendekatan deskriptif kualitatif. Dan data yang sudah diperoleh kemudian dianalisis, disajikan dalam bentuk paragraf, dan ditarik kesimpulan. Analisis yang digunakan penelitian ini yaitu menggunakan teori efektivitas dari Duncan (dalam Steers, 2008: 53) yang meliputi: pencapaian tujuan, integrasi, dan adaptasi. Hasil dari penelitian ini menunjukkan bahwa efektivitas pelayanan transportasi publik Bus Damri Pemadu Moda rute Mojokerto-Bandara
Reactive ion etching process of SiO2 film using on-site synthesized C2F4 from CF4
Authors: Iino Daiki , Tanida Satoshi , Kurihara Kazuaki , Fukumizu Hiroyuki , Sakai Itsuko , Abe Junko , Fukuhara Jota , Tanaka Rei , Tanaka Tomoyuki , Kikura Jou , Kakiuchi Hiroaki , Yasutake Kiyoshi , Ohmi Hiromasa , Hayashi Hisataka 
Published: May 2021

Abstract
C2F4 is a potential etching gas for high aspect ratio etching of SiO2 films owing to its high etch rate. However, it is difficult to fill C2F4 to a gas cylinder with high pressure for mass production due to its high reactivity. To overcome this problem, we developed an etching system, where the on-site synthesized C2F4 from CF4 using a VHF plasma was supplied directly into the etching reactor. It was demonstrated that SiO2 etching using synthesized-C2F4/O2/Ar gas mixture plasma was carried out successfully and the etch rate became 2.7 times higher than that of CF4/O2/Ar gas mixture plasma.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEPATUHAN IBU DALAM MELAKUKAN PEMENUHAN IMUNISASI DASAR BAYI USIA 0-12 BULAN
Authors: Sapardi Vivi Syofia , Yazia Velga , Andika Mira 
Published: May 2021

Prevalensi cakupan imunisasi dasar lengkap di Indonesia tahun 2018 sebesar 86,9%. Hal ini dipengaruhi oleh beberapa faktor diantaranya tingkat pengetahuan, keterjangkauan jarak rumah ke pelayanan kesehatan, dan dukungan keluarga. Dampak yang dapat ditimbulkan jika bayi tidak mencukupi imunisasi dasar lengkap adalah bayi akan menderita penyakit yang kemungkinan dapat menyebabkan kecacatan atau kematian. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang berhubungan dengan kepatuhan ibu dalam melakukan pemenuhan imunisasi dasar pada bayi usia 0-12 bulan. Penelitian ini menggunakan desain cross sectional study dengan responden 93 orang. Pengumpulan data dilaksanakan pada tanggal 2 -14 Maret 2020. Pengumpulan data dilakukan dengan cara ke rumah responden dan memberikan kuesioner kepada responden. Penelitian ini dianalisa secara univariat menggunakan table distribusi frekuensi dan bivariat menggunakan uji statistic Chi-Square. Hasil penelitian ini didapatkan 55,9% ibu tidak patuh, pengetahuan tinggi 60,2%, keluarga tidak mendukung 57%, keterjangkauan tempat pelayanan imunisasi dekat 52,5%. Adapun hasil didapatkan ada hubungan p value = 0,019 pengetahuan dengan kepatuhan ibu. Ada hubungan 0,013 dukungan keluarga dengan kepatuhan ibu dan tidak ada hubungan hubungan 0,518 keterjangkauan tempat pelayanan imunisasi dengan kepatuhan ibu. Faktor pengetahuan, dukungan keluarga mempengaruhi pemberian imunisasi dasar pada bayi. Diharapkan bagi pihak puskesmas dan tenaga kesehatan lainnya dapat meningkatkan kegiatan posyandu dan memberikan penyuluhan-penyuluhan tentang pentingnya pemberian imunisasi dasar pada bayi.
Infestação ocasional de algodoais com o pulgão Myzus persicae em São Paulo
Authors: Costa A. S. , Costa C. L. , Rossetto C. J. 
Published: May 2021

A ocorrência de Myzus persicae em algodoais no Estado de São Paulo como se deu em dezembro de 1971 e janeiro de 1972 não e fato novo e não justifica alarme por parte dos lavradores. Isso játem sido registrado anteriormente sem nenhuma sequência ameaçadora para a cultura. A ideia de que surgiu uma nova raça dessa especie, adaptada ao algodoeiro, não encontra apoio nas observações anteriores, nem nas mais recentes ou nos dados sobre a biologia da especie. Parece mais razoavel interpretar que essas infestações ocasionais registradas re¬ sultam de fortes revoadas de Myzue peraioae que só se dão em a- nos excepcionais, quando ha períodos de temperatura baixa durante o período de crescimento dos algodoais. Aplicações de inseticidas visando unicamente ao controle de Myzua peraioae em algodoais não são justificáveis economicamente na maioria dos casos. Ê mais recomendável que os lavradores se preocupem mais com o controle do pulgão comum do algodoeiro que e praga mais importante, alem de ser transmissor de moléstias de virus dessa cultura.
Influência do ataque de pentatomideos nas características agronômicas do grão da soja, Glycine max (L.) Mer
Authors: Link Dionísio , Estefanel Valduino , Santos Osmar Souza dos , Mezzomo Maria Cladis , Abreu Lie Eunice V. 
Published: May 2021

Procurou-se verificar a influência do ataque de pentatomídeos sobre as características agronómicas do grão de soja.
Determinou-se a porcentagem de grãos manchados pelo ataque destes hemípteros, a infêuncia sobre o poder germinativo, peso de 100 sementes, teor de extrato etéreo e de extrativos nitrogenados e na redução do rendimento de sete variedades de soja.
Houve influência significativa do ataque dos percevejos sobre estes fatores e entre as variedades.
Observações sobre a biologia da Orthezia insignis Browne, 1887 (Homoptera-Ortheziidae)
Authors: Nakano Octavio , Joko Tadahiro , Parra Jose Roberto P. 
Published: May 2021

A biologia da Orhezia insignis Browne foi desenvolvida em condições de laboratório, empregando-se tubérculos de Solanum tuberosum L. brotados. Dez fêmeas foram criadas, obtendo-se a duração em dias dos diferentes estágios de seu desenvolvimento. Os dados correspondem à duração máxima, mínima e media para cada estágio. Período de incubação: (31-24-28,1 dias); primeiro instar: (35-24-30,5 dias); segundo instar: (28-22-26,5 dias); terceiro instar: (35-19-27,3 dias); maturidade sexual: (5-2-3 dias); total de desenvolvimento: (103-67- 87,3 dias); pré-oviposição: (4-2-23 dias); oviposição: (41-21-31,9 dias); pré-oviposição: (11-2-6.4 dias); total da fase adulta: (56-25- 41,1 dias); longevidade: (159-92-128,4 dias); número de ovos colocado: (150-67-117,8).
A temperatura máxima para o período oscilou entre 23 a 35°C, mínima, 7 a 180C e a umidade relativa do ar variou de 52 a 95%.
Pelos dados de longevidade obtidos, pode-se admitir que pelo menos três gerações ocorrem durante o ano.
Criação Maciça de Diatraea saccharalis (Lepidoptera: Pyralidae) em Laboratório
Authors: Villacorta A. , Magro J. A. 
Published: May 2021

Na presente publicação ë descrita uma criação maciça em labora trio de Diatraea saccharalis a qual se obtém mediante a combinação de duas técnicas: na 1- usa-se espigas de milho verde, como alimento natural; e na 2ª usa-se a dieta artificial de Bowling mas com algumas modificações.
Na 1ª técnica, o recipiente usado e uma banheirinha plástica, as espigas de milho são arrumadas dentro da banheira, de modo que permita uma boa circulação de ar. A banheira e fechada com uma tampa de fermica, e tanto a parte superior como a inferior, tem uma abertura retanguiar fechada com tela metálica para ventilação e todo o conjunto fica suspenso por uma armação de ferro para isolar contra predadores.
Na 2ª técnica a dieta semi-artificial de Bowling é usada com modificações em seu conteúdo, proporções e também o tipo de recipiente, as quais tornam a operação funcional e econômica. Com ambas as técnicas e um pequeno laboratório pode-se obter uma produção diária de 3.000 lagartas de 59 instar.
Estudos biológicos sobre Leptoglossus gonagra (Fabricius, 1775), (Coreidae, Hemiptera) em laboratório
Authors: Amaral  Fº B. F. do , Storti Fº A. 
Published: May 2021

A biologia de Leptoglossus gonagra (Fabricius, 1775), foi estudada em condições de laboratório, durante a poca de janeiro a maio de 1975, utilizando como alimento folhas e frutos de aboboreira.
Foram abordados os seguintes tópicos: I. duração do período de incubação e percentagem de eclosão de ovos. II. tempos médios de - duração de cada estádio ninfal. III. estágio adulto: longevidade, razão sexual, pré-oviposição, oviposição, pós-oviposição, número de cópulas por
casal, tempo médio de cópulas e entre duas cópulas, número de posturas e número de ovos por fêmea, número de ovos por postura e tempo médio entre duas posturas. IV. duração do ciclo total. Anotaram-se as temperaturas mínima e máxima e a umidade relativa, diariamente, durante a realização do trabalho.
Observou-se que adultos são mais frequentes em certas plantas frutíferas cultivadas, e ninfas em Mormodica charantia (melão-de-São--Caetano) e Solanum americanum (maria-preta). As fêmeas efetuaram posturas de ovos sem critério fixo de escolha de local. As posturas são colocadas em forma de fileiras, com número de ovos variável. Supõem-se que a alta mortalidade observada nos primeiros estádios, foi ocasionada por alguns dos seguintes fatores: alimentação inadequada, deficiência de luz natural direta, eventualmente fotoperiodismo anormal, e isolamento de um exemplar apenas por frasco de vidro.
Este trabalho, contribui para o melhor conhecimento da biologia de L. gonagra, e podera servir como base para estudos de combate a esse inseto considerado como praga.