bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering of composite materials made of epoxy resins modified with recycled fine aggregate
Authors: Krzywiński Kamil , Sadowski Łukasz , Piechówka-Mielnik Magdalena 
Published: May 2021

Abstract
The paper presents studies performed on polymer-cementitious composite made of epoxy resin coating modified with aggregate and cementitious substrate. Epoxy resin is a perfect material that can be used to protect cementitious materials. According to its manufacturer, it can be mixed with fine aggregate. Coarse aggregate made of building demolition wastes is mostly utilized in concrete mixtures or road structures. Fine aggregate is not widely used. Therefore, the novelty of this research was the utilization of recycled fine aggregate (RFA) in epoxy resin coatings. Natural fine aggregate (NFA) was also used as an extender in the coating. The natural aggregate in the coating was partially replaced with recycled aggregate in amounts of 0, 20, 40, 60, 80, and 100% of its weight. Sixteen specimens of polymer-cementitious composites were prepared for the flexural tensile strength test, and thirty-two specimens for the compressive strength test. The macroscale tests were performed after 35 days of curing (28 days – cementitious substrate, and 7 days – epoxy resin). The results show that the epoxy resin coating does not affect the flexural tensile and compressive strength of the analyzed composites. Moreover, the type of aggregate used in the coating does not have a significant impact on the measured properties of polymer-cementitious composites. Economic analysis was performed in order to estimate the cost of the natural and RFAs used in epoxy resin coatings. The calculations show that a higher amount of RFA should be used to increase savings.
Radiological findings and clinical features for the diagnosis of adenoid hypertrophy: a study from Iraq
Authors: Alnakshabandi Abdulla , Sultan Khaled Hashim 
Published: May 2021

<p><strong>Background: </strong>Adenoid is a prevalent condition among children. Adenoidectomy has been done based on clinical symptoms. The purpose of this study is to determine the agreement between clinical features of adenoid enlargement, X-ray and adenoid size.</p><p><strong>Methods:</strong> Hundred symptomatic children were enrolled into this study at ENT. Department of Al-Bin Sina teaching hospital in Mosul city of Iraq. History was taken, clinical examination for adenoid enlargement and skull X-ray (lateral view) were performed for all children with assessment of adenoid size 1 day before operation.</p><p><strong>Results: </strong>The respondent composed of 5% male children and 46% females with average age of 6 years. Adenoid facies were the most frequent presentation followed by snoring then nasal obstruction. Around 64% had positive otoscopic findings and another 58% had hearing impairment and only 22% had ear discharge. All of the clinical findings showed (100%) sensitivity and specificity vary from (64%) to (90%). The accuracy rate for clinical features ranged from 92% to 98%. X-ray findings show a low accuracy rate (92%) in comparison to others.</p><p><strong>Conclusions: </strong>Clinical findings could be used to select children for adenoidectomy, especially when endoscopic examination is not available or cannot be performed.</p><p><strong> </strong></p>
Middle turbinate concha bullosa and its relationship with chronic sinusitis: a review
Authors: Swain Santosh Kumar 
Published: May 2021

<p class="abstract">Sinonasal diseases are serious health issues found in the clinical practice. Sinonasal diseases are often associated with anatomical variants in the sinonasal tract. There are numerous sinonasal anatomical variants found frequently in computed tomography (CT) scans of the paranasal sinuses. Middle turbinate concha bullosa is a common anatomical variant found in the nasal cavity. Pneumatization of the middle turbinate is called as concha bullosa. The pneumatization of the middle turbinate is mostly via the anterior ethmoidal air cells. Pneumatizations through posterior ethmoid air cells are also reported. There are three types of concha bullosa such as lamellar, bulbous and extensive. Majority of the patients with middle turbinate concha bullosa are asymptomatic. Sometimes this is accidentally detected during proper evaluation of the headache. Sometimes the middle turbinate concha bullosa is associated with chronic sinusitis. However, there are very few literatures which correlate the middle turbinate concha bullosa and chronic sinusitis. Although chronic sinusitis is a clinical diagnosis, the imagings like CT scan are useful to assess the extent of the disease and demonstrate the sinonasal anatomy. CT scan of the paranasal sinuses and diagnostic nasal endoscopy are important tests useful for evaluation of the middle turbinate concha bullosa and its relations with chronic sinusitis. This review article discusses on the details of the middle turbinate concha bullosa and its relationship with chronic sinusitis.</p>
Spontaneous Haemoperitoneum in Pregnancy (SHiP) with Placenta Percreta in Bicornuate Uterus with Successful Pregnancy Outcome
Authors: Santhosh Jayasree , Kharka Latha V. , Kamona Atheel , Al Amri Sumaiya S. 
Published: May 2021

Intraperitoneal haemorrhage during pregnancy or postpartum without any history of trauma is termed Spontaneous Haemoperitoneum in Pregnancy (SHiP). This is a rare condition, causing significant morbidity and mortality for the mother and the neonate. We report a case of SHiP in a patient who presented to us at 31 weeks of gestation with right iliac fossa pain, pallor and tachycardia. Radiological investigations revealed intraperitoneal bleeding and a right adnexal haematoma. She was managed conservatively with blood transfusion and supportive care. At 36 weeks of gestation, lower segment caesarean section (LSCS) was done and a live baby with good Apgar score was delivered. Per-operatively, she was found to have a bicornuate uterus, placenta percreta at the junction of the horns and a right adnexal haematoma. This case highlights the significance of thorough evaluation of acute abdominal pain in pregnancy in avoiding unnecessary surgical intervention and iatrogenic prematurity.
Keywords: Abdominal pain; Caesarean Section; Hemoperitoneum; Placenta accreta; Pregnancy.
Diagnosis of Guillain-Barré Syndrome After Total Hip Arthroplasty
Authors: Tesoriero Paul , Feng James E. , Anoushiravani Afshin A. , Kiprovski Kiril , Marwin Scott , Wiznia Daniel 
Published: May 2021

Case Report:
A 67-year-old man presented with signs of acute periprosthetic infection after total hip arthroplasty (THA). Surgical debridement, antibiotics, and a head and liner exchange were performed. After showing no improvement, a single-stage revision was conducted. Postoperatively, he developed back pain and lower extremity weakness. Electrodiagnostic studies showed a Guillain-Barré syndrome (GBS) variant. Intravenous immunoglobulin was administered to halt disease progression. After 1 year, he still demonstrated neuromuscular deficits and required a cane for ambulation.

Conclusion:
This case highlights GBS after THA. A high degree of clinical suspicion is essential to prevent misinterpretation as a postsurgical complication.

Level of Evidence:
V, case report
Cause-Specific Mortality and Natural Disasters — The Urgent Need for Change
Authors: Finnigan Gerard A 
Published: May 2021

The global threat from natural hazard disasters is accelerating, driven by the earth’s deteriorating natural ecosystems, damaged physical environment, rapid urbanisation and population growth. Internationally agreed targets within the Sendai Framework for Disaster Risk Reduction (SFDRR) aim to halt the escalating risk and reduce disaster-related deaths and global impact.
Achieving SFDRR targets requires a robust estimation of global disaster-mortality and targeted health interventions so that people at risk are protected and their deaths are prevented. This study examined whether the information published in medical and scientific literature on cause-specific mortality was reflected in global data collection and reporting.
Degradation of Oxytetracycline by Electrochemical, Fenton and Electro-fenton Processes Using SS316 and SS316/β-PbO2 Anodes: Process Optimization Using Rsm-ccd, Bioassay Test and Degradation Pathway
Authors: Hasani Kamal , Hosseini Sama , Gholizadeh Heliya , Dargahi Abdollah , Vosoughi Mehdi 
Published: May 2021

Abstract
The aim of the present study was to evaluate the efficiency of advanced oxidation processes (electrochemical, Fenton and electro-Fenton) in the removal of oxytetracycline using SS316 and SS316/β-PbO2 anodes. This study was performed experimentally on a laboratory scale in a 250 mL reactor. First, experiments were designed for the electrochemical process using a central composite design, and the optimal conditions for the variables pH(3.53), electric current density(3.85mA/cm2), initial concentration of oxytetracycline (20mg/L) and electrolysis time (42.35min) was obtained; then, under these conditions, the efficiency of Fenton process with FeSO4 variable without the presence of electrodes was evaluated, and its optimal value was 0.3 g/L, and then in the presence of optimal values ​​of the above 5 variables, the efficiency of electro-Fenton process with H2O2 changes were investigated and the optimal value of 0.12 was obtained for H2O2. The removal efficiencies of oxytetracycline in electrochemical, Fenton, and electro-Fenton processes were 84.7%, 73.4%, and 98.2%, respectively. Under optimal conditions, the SS316/β-PbO2 anode electrode enhanced the oxytetracycline efficiency by electron-Fenton process to 100%. The results of bioassay with microorganisms showed that the reduction of toxicity of the effluent treated by electro-Fenton process for Pseudomonas aeruginosa and Staphylococcus aureus was 84.5% and 69%, respectively.
Long-Term Tolerability and Efficacy of Carboplatin/Pemetrexed as Maintenance Therapy for a Patient With Lung Adenocarcinoma
Authors: Ju Lixia , Yang Juan 
Published: May 2021

Abstract
BackgroundIt is widely known that platinum-based doublet chemotherapy (PBC) only can be applied to first-line patients with non-small cell lung cancer (NSCLC) with good performance for 4-6 cycles. However, in this case report the patient has been treated with PBC for 30 cycles and more than three years. Case presentationA 63-year-old Chinese man was diagnosed with stage IVa lung adenocarcinoma, with Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0. This patient did not respond to pemetrexed alone, but respond to pemetrexed and carboplatin, and once the chemotherapy was interrupted for more than two months, the disease would progressed. Moreover, there was little adverse reactions (AE), so we have treated him with PBC for 30 cycles and the progression-free survival (PFS) will be more than three years.ConclusionsThis is the first time to report PBC as maintenance therapy in patients with NSCLC. We hope that oncologists will notice that some diseases are very aggressive, and maintenance therapy are very important to some patients and may help to get longer overall survival time.
SARS-CoV-2 Infection Elicits A Greater Humoral Immune Response In The Second Wave Than The First Wave In Morocco
Authors: Ezzikouri Sayeh , Majidi Hind , Redwane Soad , Meziane Nadia , Zahir Abdellatif , Abbadi Islam , Zerrad Chaimaa , Haddaji Asmaa , Abounouh Karima , Hilmi Soufiane , Aqillouch Safaa , Elmessaoudi-Idrissi Mohcine , Laazaazia Oumaima , Ainahi Abdelhakim , Rmili Nabila , Maaroufi Abderrahmane , Benjelloun Soumaya 
Published: May 2021

Abstract
Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing pandemic of coronavirus disease 2019 (COVID-19). One year has passed since the first COVID-19 case, and concerns have emerged regarding new variants, meaning that characterizing antibody-mediated immune response dynamics is of paramount importance. Here, we evaluated the humoral immune response against SARS-CoV-2 in subjects during the first and second waves of the pandemic in Morocco. Methods: We assessed humoral immune response in samples from 94 seropositive individuals in the first wave (February to August 2020) and 596 seropositive individuals in the second wave (December 2020 to January 2021). Plasma samples were collected from volunteer blood donors and their levels of serum IgG to SARS-CoV-2 nucleoprotein (NP) were determined using architect SARS-CoV-2 IgG chemiluminescence microparticle immunoassay.Results: Our results revealed an increase of humoral immunity during the second wave than first wave (3.897 ± 0.079 vs. 2.842 ± 0.153, respectively, p<0.0001). Notably, we found an age-related gradient in antibody level, with higher antibody index in subjects at 45 years old and above (p= 0.01451). However, no significant difference was found according to gender (p= 0.8629). Conclusions: Our data highlighted an important issue regarding antibody-mediated immune response against SARS-CoV-2 infection during the second wave and this issue might have arisen due to the dynamics of different strains circulating during the progress of the pandemic.
Process Evaluation of a Complex Workplace Intervention to Prevent Musculoskeletal Pain in Nursing Staff: Results From INTEVAL_Spain.
Authors: Soler-Font Mercè , Ramada José Maria , Merelles Antoni , Amat Anna , Flor Carmen de la , Martínez Olga , Palma-Vasquez Claudia , Sancho Consuelo , Peña Pilar , Bültmann Ute , Zon Sander K. R. van , Serra Consol 
Published: May 2021

Abstract
Background: The nursing staff is an occupational group at high risk of musculoskeletal pain. Scientific evidence has shown that multifaceted interventions are more effective than those based on a single component to prevent musculoskeletal pain. INTEVAL_Spain was a complex workplace intervention to prevent and manage musculoskeletal pain among nursing staff. Objectives: This study performed a process evaluation of INTEVAL_Spain and aimed to examine whether the intervention was conducted according to the protocol, to investigate the fulfilment of expectations and the satisfaction of workers.Methods: The intervention was a two-armed cluster randomized controlled trial and lasted one year. The process evaluation included quantitative and qualitative methods. Quantitative methods were used to address the indicators of Steckler and Linnan’s framework. Data on recruitment was collected through a baseline questionnaire for the intervention and the control group. Reach and dose received were collected through participation sheets, dose delivered and fidelity through internal registries, and fulfilment of expectations and satisfaction were collected with two questions at 12-months follow-up. Qualitative methods were used for a content analysis of discussion groups at the end of the intervention led by an external moderator to explore satisfaction and recommendations. The general communication and activities were discussed, and final recommendations were agreed on. Data were synthesized and results were reported thematically.Results: The study was performed in two Spanish hospitals during 2016-2017 and 257 workers participated. Recruitment was 62% and 51% for the intervention and the control group, respectively. The reach of the activities ranged from 96% for participatory ergonomics to 5% for healthy diet. The number of sessions offered ranged from 60 sessions for Nordic walking to one session for healthy diet. Fidelity of workers ranged from 100% for healthy diet and 79% for participatory ergonomics, to 42% and 39% for Nordic walking and case management, respectively. Lowest fidelity of providers was 75% for case management and 82% for Nordic walking. Fulfilment of expectations and satisfaction ranged from 6.6/10 and 7.6/10, respectively, for case management to 10/10 together for the healthy diet session. Discussion groups revealed several limitations for most of the activities, mainly focused on a lack of communication between the Champion (coordinator) and the workers. Conclusions: This process evaluation showed that the implementation of INTEVAL_Spain was predominantly carried out as intended. Process indicators differed depending on the activity. Several recommendations to improve the intervention implementation process are proposed.Study registration: ISRCTN15780649
Development of a New Screening Method “Allele Matching Cut Off Score (AMCOS)” for Faster Kinship Analysis in Cases of Mass Disasters: A Proof of Concept Study
Authors: Kakkar Sonia , Sarma Phulen , Pannigrihi Inusha , Mandal S. P. , Kumawat R. K. , Shrivastava Pankaj 
Published: May 2021

Abstract
kinship analysis in forensic is based on calculation of respective kinship indices. But calculation of the same is possible only when the subject under identification has been associated to a particular population whose gene frequency data is available for the particular set of markers used in forensic practices. In case of the mass disasters where a huge number of individuals are to be identified, gathering the population frequency data and calculating the kinship indices can be an intricate progression requiring a lot of time and huge resources. The present study is based on allele matching score values which doesn’t require the use of allele frequency data to establish kinship. This method is based on the allele sharing approach which simply refers to the number of shared alleles (1 or 2) between two individuals; also known as identical by state (IBS) alleles which might have been inherited from a recent common ancestor in which the alleles are identical by descendent (IBD). In case of mass disasters this method can be used to narrow down the investigation by screening the number of related individuals which can further be confirmed with other tests if required. This method has been tested for various statistical parameters and has shown promising values which suggests the potential use of this method in forensic practice. This method has been tested on siblings and grandparent-grandchildren by using autosomal and X-STR markers both as the reference samples from parents can’t always be available. The present study also compares the results shown by autosomal and X-STR markers in siblings and grandparent-grandchildren identification, thereby suggesting the better set of markers for siblings and grandparent-grandchildren identification.
Aeollanthus Pubescens Benth Leaf Essential Oil: Its Chemical Composition and the Insecticidal Activity Against the Malaria Vector Anopheles Gambiae (Diptera: Culicidae)
Authors: BOHOUNTON Roméo Barnabé , Djogbenou Luc , Djihinto Oswald Yédjinnavênan , Dedome Oronce Sedjro-Ludolphe , Sovegnon Pierre Marie , Barea Bruno , Adomou Aristide , Villeneuve Pierre , Tchobo Fidèle Paul 
Published: May 2021

Abstract
Background: The use of synthetic insecticides is responsible for many cases of resistance in insects. Therefore, the use of natural molecules of ecological interest with insecticidal properties turns out to be an alternative approach to the use of synthetic insecticides. This study aims at investigating the larvicidal, adulticidal activity and the chemical composition of the essential oil of Aeollanthus pubescens Benth on the major malaria vector Anopheles gambiae.The leaves of Aeollanthus pubescens were collected in the South of the Republic of Benin.Methods: Three reference strains of Anopheles gambiae s.s. such as Kisumu, Kiskdr and Acerkis were used. The standard WHO guideline for larvicides evaluation was used and the chemical composition of the essential oil was analysed by gas chromatography coupled to mass spectrometry. Adult mosquitoes were exposed to the fragment nets coated with the essential oil for 3 min. Probit regression analysis was used for LC50 , LC95 , KDT50 , and KDT95 calculations. The difference between the mortality‐dose regressions for the different strains was analysed using the likelihood ratio test (LRT). The Log-rank test was performed to evaluate the difference in survival between the strains.Results: Fourteen components were identified representing 98.31% of the total of oil. The major components were carvacrol (51.06 %), thymyle acetate (14.01 %) and ɣ-terpinene (10.60 %). The essential oil has remarkable larvicidal properties with LC50 of 29.57, 22.95, and 28.37 ppm respectively on Kisumu, Acerkis and Kiskdr strains. With the fragment net treated at 165 µg/cm2, the KDT50 of both Acerkis (1.71 s, p < 0.001) and Kiskdr (2.67 s, p < 0.001) individuals were significantly lower than that of Kisumu (3.77 s). The lifespan of the three mosquito strains decreased respectively to one day for Kisumu (p < 0.001), two days for Acerkis (p < 0.001) and three days for Kiskdr (p < 0.001) compared to their control.Conclusion: Our findings show that the Aeollanthus pubescens essential oil is an efficient larvicide and adulticide against malaria vector Anopheles gambiae. This bioinsecticidal activity is a promising discovery for the control of the resistant malaria-transmitting vectors.
Phase 1b Study of Ramucirumab in Combination With Erlotinib or Osimertinib for Untreated EGFR-mutated Non–small Cell Lung Cancer Patients With Asymptomatic Brain Metastases
Authors: Kaneda Hiroyasu , Sawa Kenji , Daga Haruko , Okada Asuka , Nakatani Yuki , Atagi Shinji , Okishio Kyoichi , Tani Yoko , Matsumoto Yoshiya , Ogawa Koichi , Nakahama Kenji , Izumi Motohiro , Mitsuoka Shigeki , Kawaguchi Tomoya 
Published: May 2021

Abstract
Objectives: The study was designed to investigate the safety and tolerability of ramucirumab administered in combination with erlotinib or osimertinib for patients with untreated EGFR-mutated non–small cell lung cancer (NSCLC) and asymptomatic brain metastases, a patient subgroup in which these regimens have remained untested.Materials and methods: This multicenter phase 1b study (RELAY-Brain) consisted of two cohorts with three patients each. The two cohorts were assessed independently of one another and were not compared. Patients whose asymptomatic brain metastases had or had not undergone prior local therapy received ramucirumab (10 mg/kg) every 2 weeks plus either erlotinib (150 mg/day) or osimertinib (80 mg/day) until disease progression or intolerable toxicity. The primary objective of the study was to assess dose-limiting toxicity (DLT), defined as central nervous system (CNS) hemorrhage of grade ³2. Secondary end points included safety profile, objective response (systemic and intracranial), and disease control rate.Results: Six patients were enrolled in the study. Neither DLT nor serious or unexpected adverse events were observed. At the time of this analysis, discontinuation of the study drugs had also not occurred. One treatment-related adverse event of grade ³3 (hypertension of grade 3) was apparent. Common adverse events were generally manageable. The median number of ramucirumab administrations was 18.5 (range, 13 to 31), and there were no detected episodes of CNS hemorrhage. Four patients experienced at least one dose delay for ramucirumab, but there were no dose reductions or omissions for this drug. Five of the six patients showed an objective systemic response. Although only one patient had a measurable CNS lesion at baseline, a confirmed intracranial partial response was observed. Conclusion: Ramucirumab in combination with erlotinib or osimertinib showed promising safety and efficacy for EGFR-mutated NSCLC with brain metastases.Clinical trial registration: Japan Registry of Clinical Trials (jRCTs2051190027)