bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is diabetic neuropathy associated with vitamin D status? A meta-analysis
Authors: Yammine Kaissar , Abi Kharma Joelle , Kaypekian Theodore , Assi Chahine , Zeeni Nadine 
Published: May 2021

AbstractSeveral studies have been conducted to investigate the relation between 25-hydroxyvitamin D [25(OH)D] level and diabetic neuropathy (DN). However, there is still no clear conclusion due to differences in study design and cut-off values used in the published work, in addition to the absence of a comprehensive meta-analysis (MA) on the topic. The present systematic review and MA therefore aims at clarifying the association between vitamin D level and peripheral DN in patients with type 2 diabetes mellitus. Primary research studies that explored the association between 25(OH)D level and diabetic peripheral neuropathy in type 2 diabetes were located from Medline, EMBASE, Web of Science, Cochrane Library, CINHAL and Google Scholar. Twenty-six studies met the inclusion criteria with 6277 participants where 2218 were diabetic with DN, 2959 were diabetic without DN and 406 were healthy. Diabetic patients with DN showed significantly lower serum 25(OH)D compared with patients without DN (standardised mean difference (SMD) of −0·92 (95 % CI −1·18, −0·65, I2 = 93·3 %, P < 0·0001). The pooled OR value of vitamin D deficiency was higher in patients with DN, 1·84 (95 % CI 1·46, 2·33, P < 0·0001) and 2·87 (95 % CI 1·10, 7·52, P = 0·03) when using fixed-effects and random-effects models, respectively. Vitamin D deficiency has been found to be highly prevalent among diabetic patients with neuropathy. Since 25(OH)D has been implicated in glucose haemostasis and showed benefit in reducing neuropathy symptoms, its supplementation is warranted for this population of patients.
Fertility intentions among the working population of Dalian City born between 1980 and 1989
Authors: Qiu Hongyan , Zhang Qun , Zhang Jin , Wang Qingshan , Liu Lihong , Yang Jie , Hou Liyan 
Published: May 2021

AbstractIn October 2015, the Chinese Government announced that the one-child policy had finally been replaced by a universal two-child policy. China’s universal two-child policy is highly significant because, for the first time in 36 years, no one in an urban city is restricted to having just one child. This cross-sectional study was conducted to explore future fertility intentions and factors influencing individual reproductive behaviour (whether to have two children) in Dalian City. A total of 1370 respondents were interviewed. The respondents’ mean ideal number of children was only 1.73, and urban respondents’ sex preference was symmetrical. A total of 19.0% of the respondents were unmarried, 64.5% were married and had childbearing experience and only 6.3% of married respondents had two children. Among the 1370 participants, 30.4% stated that they would have a second child, while 69.6% refused to have a second child in the future. Binary logistic regression analysis (Model 1) showed that the following characteristics were associated with having only one child in the future: being female, being older, having a lower education level, being born in Dalian, having a lower family income and reporting one child as the ideal number of children. Model 2 (comprising only respondents with childbearing experience) showed that respondents who were female, had a lower family income and were unable to obtain additional financial support from parents were more likely to intend to stick at one child. In addition, respondents’ ideal number of children and childbearing experiences had a significant influence on future fertility intentions. These results suggest that fertility intentions and reproductive behaviours are still below those needed for replacement level fertility in Dalian City. China’s policymakers should pay more attention to these factors (socioeconomic characteristics, economic factors, desired number of children and childbearing experiences) and try to increase individual reproductive behaviour.
Feeding wheat dried distillers’ grains with solubles increases conjugated linoleic acid and unsaturated lipids in ovine milk without adversely affecting milk yield
Authors: Neofytou Marina C. , Michael Charoulla , Constantinou Constantina , Sparaggis Dionysis , Tzamaloukas Ouranios 
Published: May 2021

AbstractThe aim of this research communication was to examine the effect of dietary supplementation with wheat-based dried distillers’ grains with solubles (DDGS), a by-product of bioethanol production, on yield, composition, and fatty acid (FA) profile of ewe milk. Forty-five purebred mid-lactating Chios ewes (average milk yield 2.23 kg/d in 96 ± 5 d in lactation) were offered three iso-nitrogenous and iso-energetic diets (15 animals per diet) for a 10 d adaptation period followed by a 5-week recording and sampling period. The diets contained 0, 6, and 12% DDGS on DM basis for the DG0, DG6, and DG12 treatment, respectively, as a replacement of concentrate mix, whilst concentrate-to-forage ratio remained at 60:40 in all treatments. Individual milk yield, milk composition, and FA profile were recorded weekly and analyzed using a complete randomized design with repeated measurements. No significant differences were observed among groups concerning dry matter intake (overall mean of 2.59 kg/d), milk yield or 6% fat-corrected milk and milk protein percentage or protein yield. Milk fat percentage was decreased in the DG12 (4.76%) compared to DG0 (5.69%) without, however, significantly affecting the daily output of milk fat. The concentration of all major saturated FA between C4:0 to C16:0 was reduced, whereas long-chain (>16 carbons), mono-unsaturated and poly-unsaturated FAs were increased in the milk of DDGS groups. Among individual FA, increments of oleic acid and C18:1 trans-monoenes like C18:1 trans-10 and C18:1 trans-11 were demonstrated in DG12 group, whereas linoleic and conjugated linoleic acid (CLA cis-9, trans-11) were elevated in both DDGS groups compared to control. Changes in FA profile resulted in a decline in the atherogenic index of milk by 20% and 35% in DG6 and DG12 treatments, respectively, compared with control. In conclusion, feeding DDGS to dairy ewes increased the levels of unsaturated FA that are potentially beneficial for human health without adversely affecting milk, protein or fat yield.
Predictive validity of psychosis risk models when applied to adolescent psychiatric patients
Authors: Lindgren Maija , Kuvaja Heidi , Jokela Markus , Therman Sebastian 
Published: May 2021

Abstract

Background
Several multivariate algorithms have been developed for predicting psychosis, as attempts to obtain better prognosis prediction than with current clinical high-risk (CHR) criteria. The models have typically been based on samples from specialized clinics. We evaluated the generalizability of 19 prediction models to clinical practice in an unselected adolescent psychiatric sample.

Methods
In total, 153 adolescent psychiatric patients in the Helsinki Prodromal Study underwent an extensive baseline assessment including the SIPS interview and a neurocognitive battery, with 50 participants (33%) fulfilling CHR criteria. The adolescents were followed up for 7 years using comprehensive national registers. Assessed outcomes were (1) any psychotic disorder diagnosis (n = 18, 12%) and (2) first psychiatric hospitalization (n = 25, 16%) as an index of overall deterioration of functioning.

Results
Most models improved the overall prediction accuracy over standard CHR criteria (area under the curve estimates ranging between 0.51 and 0.82), although the accuracy was worse than that in the samples used to develop the models, also when applied only to the CHR subsample. The best models for transition to psychosis included the severity of positive symptoms, especially delusions, and negative symptoms. Exploratory models revealed baseline negative symptoms, low functioning, delusions, and sleep problems in combination to be the best predictor of psychiatric hospitalization in the upcoming years.

Conclusions
Including the severity levels of both positive and negative symptomatology proved beneficial in predicting psychosis. Despite these advances, the applicability of extended psychosis-risk models to general psychiatric practice appears limited.
Modifiable risk factors for inpatient violence in psychiatric hospital: prospective study and prediction model
Authors: Fazel Seena , Toynbee Mark , Ryland Howard , Vazquez-Montes Maria , Al-Taiar Hasanen , Wolf Achim , Aziz Omar , Khosla Vivek , Gulati Gautam , Fanshawe Thomas 
Published: May 2021

Abstract

Background
Violence perpetrated by psychiatric inpatients is associated with modifiable factors. Current structured approaches to assess inpatient violence risk lack predictive validity and linkage to interventions.

Methods
Adult psychiatric inpatients on forensic and general wards in three psychiatric hospitals were recruited and followed up prospectively for 6 months. Information on modifiable (dynamic) risk factors were collected every 1–4 weeks, and baseline background factors. Data were transferred to a web-based monitoring system (FOxWeb) to calculate a total dynamic risk score. Outcomes were extracted from an incident-reporting system recording aggression and interpersonal violence. The association between total dynamic score and violent incidents was assessed by multilevel logistic regression and compared with dynamic score excluded.

Results
We recruited 89 patients and conducted 624 separate assessments (median 5/patient). Mean age was 39 (s.d. 12.5) years with 20% (n = 18) female. Common diagnoses were schizophrenia-spectrum disorders (70%, n = 62) and personality disorders (20%, n = 18). There were 93 violent incidents. Factors contributing to violence risk were a total dynamic score of ⩾1 (OR 3.39, 95% CI 1.25–9.20), 10-year increase in age (OR 0.67, 0.47–0.96), and female sex (OR 2.78, 1.04–7.40). Non-significant associations with schizophrenia-spectrum disorder were found (OR 0.50, 0.20–1.21). In a fixed-effect model using all covariates, AUC was 0.77 (0.72–0.82) and 0.75 (0.70–0.80) when the dynamic score was excluded.

Conclusions
In predicting violence risk in individuals with psychiatric disorders, modifiable factors added little incremental value beyond static ones in a psychiatric inpatient setting. Future work should make a clear distinction between risk factors that assist in prediction and those linked to needs.
What constitutes successful covert action? Evaluating unacknowledged interventionism in foreign affairs
Authors: Cormac Rory , Walton Calder , Puyvelde Damien Van 
Published: May 2021

AbstractCovert action has long been a controversial tool of international relations. However, there is remarkably little public understanding about whether it works and, more fundamentally, about what constitutes success in this shadowy arena of state activity. This article distills competing criteria of success and examines how covert actions become perceived as successes. We develop a conceptual model of covert action success as a social construct and illustrate it through the case of ‘the golden age of CIA operations’. The socially constructed nature of success has important implications not just for evaluating covert actions but also for using, and defending against, them.
Centers and Azumaya loci for finite W-algebras in positive characteristic
Authors: SHU BIN , ZENG YANG 
Published: May 2021

AbstractIn this paper, we study the center Z of the finite W-algebra
$${\mathcal{T}}({\mathfrak{g}},e)$$
associated with a semi-simple Lie algebra
$$\mathfrak{g}$$
over an algebraically closed field
$$\mathbb{k}$$
of characteristic p≫0, and an arbitrarily given nilpotent element
$$e \in{\mathfrak{g}} $$
We obtain an analogue of Veldkamp’s theorem on the center. For the maximal spectrum Specm(Z), we show that its Azumaya locus coincides with its smooth locus of smooth points. The former locus reflects irreducible representations of maximal dimension for
$${\mathcal{T}}({\mathfrak{g}},e)$$
.
Understanding the role of smoking and chronic excess alcohol consumption on reduced caloric intake and the development of sarcopenia
Authors: Prokopidis Konstantinos , Witard Oliver C. 
Published: May 2021

AbstractThis narrative review provides mechanistic insight into the biological link between smoking and/or chronic excess alcohol consumption, and increased risk of developing sarcopenia. Although the combination of excessive alcohol consumption and smoking is often associated with ectopic adipose deposition, this review is focused on the context of a reduced caloric intake (leading to energy deficit) that also may ensue due to either lifestyle habit. Smoking is a primary cause of periodontitis and chronic obstructive pulmonary disease that both induce swallowing difficulties, inhibit taste and mastication, and are associated with increased risk of muscle atrophy and mitochondrial dysfunction. Smoking may contribute to physical inactivity, energy deficit via reduced caloric intake, and increased systemic inflammation, all of which are factors known to suppress muscle protein synthesis rates. Moreover, chronic excess alcohol consumption may result in gut microbiota dysbiosis and autophagy-induced hyperammonemia, initiating the up-regulation of muscle protein breakdown and down-regulation of muscle protein synthesis via activation of myostatin, AMPK and REDD1, and deactivation of IGF-1. Future research is warranted to explore the link between oral healthcare management and personalised nutrition counselling in light of potential detrimental consequences of chronic smoking on musculoskeletal health outcomes in older adults. Experimental studies should investigate the impact of smoking and chronic excess alcohol consumption on the gut–brain axis, and explore biomarkers of smoking-induced oral disease progression. The implementation of behavioural change interventions and health policies regarding smoking and alcohol intake habits may mitigate the clinical and financial burden of sarcopenia on the healthcare system.
Along the fringes of Agency: neurodevelopmental account of the obsessive mind
Authors: Poletti Michele , Gebhardt Eva , Raballo Andrea 
Published: May 2021

AbstractThe experiential core of the obsessive mind rests on subtle, primary mental phenomena (such as obsessions and so called “sensory phenomena”) which precede and trigger behavioral compulsions. Converging evidence supports a possible pathophysiological role for altered corollary discharge (phenotypically expressed in sensorimotor symptoms and contributing to a reduced Sense of Agency [SoA]), in the neurodevelopment of obsessions and “sensory phenomena.” In phenomenological terms, “sensory phenomena” may represent the subjective experiential resonance of an individual history of persistent inaccurate sensory predictions, whereas accompanying manifestations, such as the obsessive need for order and symmetry, may represent a compensatory attempt to mitigate “sensory phenomena” (eg, by increasing the sensory predictability of the surrounding world). Since disturbances of both SoA and Sense of Ownership have been thematized as potential pathogenetic factors in the neurodevelopment of the psychotic mind, a dimensional account of altered sensorimotor prediction may partly explain the affinities (and high comorbidity) between obsessive–compulsive disorder and schizophrenia spectrum disorders.
Is quetiapine effective for obsessive and compulsive symptoms in patients with bipolar disorder? A randomized, double-blind, placebo-controlled clinical trial
Authors: Sahraian Ali , Ghahremanpouri Bahareh , Mowla Arash 
Published: May 2021

AbstractBackgroundThe aim of this study is to examine the effects of quetiapine as an adjuvant treatment for obsessive–compulsive (OC) symptoms in patients with bipolar disorder (BD) type I.MethodsIn this 8-week double-blind placebo-controlled randomized clinical trial, 47 patients with BD in euthymic phase that had OC symptoms were randomly allocated to receive either quetiapine or placebo plus their routine medications (lithium + clonazepam). Yale–Brown Obsessive–Compulsive Scale (YBOCS) was used to assess the outcomes. Adverse effects were also recorded.ResultsOf 47 BD patients with OC symptoms that were randomly allocated in two groups of quetiapine (n = 24) and placebo group (n = 23), 40 patients (20 in quetiapine group and 20 in placebo group) completed the trial. Throughout the trial, the mean score of YBOCS in the quetiapine group dropped from 24.37 ± 1.51 to 15.26 ± 1.16 (P < .001) and in the placebo group decreased from 24.21 ± 1.33 to 23.94 ± 1.66 (P = 1.97). At the end of the study, 12 (60%) patients in the quetiapine group and 1 (5%) patient in the placebo group had more than 34% decline in YBOCS score (P < .001). No serious adverse effects were reported in two groups.ConclusionsOur double-blind placebo-controlled clinical trial showed that quetiapine may be an effective adjuvant agent for reducing OC symptoms in BD patients.
Automated evaluation of the quality of ideas in compositions based on concept maps
Authors: Yang Li-Ping , Xin Tao , Luo Fang , Zhang Sheng , Tian Xue-Tao 
Published: May 2021

AbstractNowadays, automated essay evaluation (AEE) systems play an important role in evaluating essays and have been successfully used in large-scale writing assessments. However, existing AEE systems mostly focus on grammar or shallow content measurements rather than higher-order traits such as ideas. This paper proposes a new formulation of graph-based features for concept maps using word embeddings to evaluate the quality of ideas for Chinese compositions. The concept map derived from the student’s composition is composed of the concepts appearing in the essay and the co-occurrence relationship between the concepts. By utilizing real compositions written by eighth-grade students from a large-scale assessment, the scoring accuracy of the computer evaluation system (named AECC-I: Automated Evaluation for Chinese Compositions—Ideas) is higher than the baselines. The results indicate that the proposed method deepens the construct-relevant coverage of automatic ideas evaluation in compositions and that it can provide constructive feedback for students.
‘To Possess the Power to Speak’
Authors: Alcoff Linda Martín 
Published: May 2021

AbstractI argue here that first person speech on sexual violence remains an important dimension of the movement for social change in regard to sexual violence, and that the public speech of survivors faces at least three groups of obstacles: 1) the problem of epistemic injustice, that is, injustice in the sphere of knowledge 2) the problem of language and power, and 3) the problem of dominant discourses. I explain and develop these points and end with a final argument concerning the critical importance of speaking publicly on these areas of human experience.
Expression of Acute Phase Protein, Glial Fibrillary Acidic Protein, Epithelial Cadherin, and S100 Protein in Brain Tissues from Natural Cases of Ovine Encephalitic Listeriosis
Authors: Khafaga Asmaa F. , Abdullaziz Ibrahim A. , Abd-Elrahman Amir H. , Elshahawy Ibrahim I. 
Published: May 2021

Abstract
James Croll and 1876: an exceptional year for a ‘singularly modest man’
Authors: EDWARDS Kevin J. 
Published: May 2021

ABSTRACTJames Croll left school at the age of 13 years, yet while a janitor in Glasgow he published a landmark paper on astronomically-related climate change, claimed as ‘the most important discovery in paleoclimatology’, and which brought him to the attention of Charles Darwin, William Thomson and John Tyndall, amongst others. By 1867 he was persuaded to become Secretary and Accountant of the newly established Geological Survey of Scotland in Edinburgh, and a year after the appearance of his keynote volumeClimate and timein 1875, he was lauded with an honorary doctorate from Scotland's oldest university, Fellowship of the Royal Society of London and Honorary Membership of the New York Academy of Sciences. Using a range of archival and published sources, this paper explores aspects of his ‘journey’ and the background to the award of these major accolades. It also discusses why he never became a Fellow of his national academy, the Royal Society of Edinburgh. In the world of 19th-Century science, Croll was not unusual in being both an autodidact and of humble origins, nor was he lacking in support for his endeavours. It is possible that a combination of Croll's modesty and innovative genius fostered advancement, though this did not hinder a willingness to engage in vigorous argument.
Simulation of Aerosol Indirect Effects on Cloud Streets Over the Northwestern Pacific Ocean
Authors: Wu Chung‐Kai , Chen Jen‐Ping 
Published: May 2021

AbstractWe simulated aerosol effects on cloud streets formed during continental cold‐air outbreaks over the Northwestern Pacific using an aerosol‐sensitive cloud microphysical scheme coupled with the Weather Research and Forecast model. The micro‐ and macro‐scale responses were examined under a wide range of aerosol concentrations. The cloud streets generally remain in a transient state, indicating that the aerosol particles may significantly affect the cloud system's development. The simulation results revealed a clear Twomey effect, but they were contrary to some of the Albrecht effect, especially under relatively clean conditions. Such reversed Albrecht effects stem mainly from dynamic response to changes in atmospheric stability associated with drizzle evaporation in the sub‐cloud layer. The dynamic response works against thermal forcing from the large air‐sea temperature gradient in a cold‐air outbreak. As the aerosol increases, the drizzle mechanisms weaken, and the boundary layer becomes more convective, leading to stronger dry‐air entrainment from the free troposphere. In individual clouds, the effect of entrainment on cloud water content may be compensated by more substantial vertical vapor flux. These mechanisms lead to a reduction in the cloud amount. Furthermore, the reduced moisture flux from drizzle evaporation in the sub‐cloud layer, as well as the reduced sedimentation speed of the smaller cloud drops, tend to lessen cloud thickness. The overall reduction in cloud dimensions may offset the Twomey effect by up to 20% in cloud albedo.
Spatiotemporal Peatland Productivity and Climate Relationships Across the Western South American Altiplano
Authors: Anderson Talia G. , Christie Duncan A. , Chávez Roberto O. , Olea Matias , Anchukaitis Kevin J. 
Published: May 2021

AbstractThe South American Altiplano is one of the largest semiarid high‐altitude plateaus in the world. Within the Altiplano, peatlands known as “bofedales” are important components of regional hydrology and provide key water resources and ecosystem services to Andean communities. Warming temperatures, changes in hydroclimate, and shifting atmospheric circulation patterns all affect peatland dynamics and hydrology. It is therefore urgent to better understand the relationships between climate variability and the spatiotemporal variations in peatland productivity across the Altiplano. Here, we explore climate influences on peatland vegetation using 31 years of Landsat data. We focus specifically on the bofedal network in the western Altiplano, the driest sector of the plateau, and use the satellite‐derived Normalized Difference Vegetation Index (NDVI) as an indicator of productivity. We develop temporally and spatially continuous NDVI products at multiple scales in order to evaluate relationships with climate variables over the past three decades. We demonstrate that cumulative precipitation and snow persistence over the prior 2 years are strongly associated with growing season productivity. A step change in peatland productivity between 2013–2015 drives an increasing trend in NDVI and is likely a response to consecutive years of anomalously high snow accumulation and rainfall. Early summer minimum temperatures emerge as a secondary influence on productivity. Understanding large‐scale productivity dynamics and characterizing the response of bofedales to climate variability over the last three decades provides a baseline to monitor the responses of Andean peatlands to climate change.