bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined particle swarm optimization and Ant Colony System for energy efficient cloud data centers
Authors: M Mahil , T Jayasree 
Published: February 2021

AbstractOne of the foremost issues deliberated by the cloud infrastructure providers is to minimize the costs by reducing energy consumption. Though many heuristic algorithms such as Genetic Algorithm (GA), Simulated Annealing (SA), and so on, have been existed for task scheduling or server consolidation to reduce energy consumption, more energy savings in data centers is required. In this paper, a combination of two distinctive heuristic algorithms, namely Particle Swarm Optimization (PSO) technique for proficient task scheduling and Ant Colony System (ACS) for effective server consolidation are proposed. In PSO, each particle in the swarm finds a task scheduling solution and updates the best solution. It is faster than many meta‐heuristic algorithms. In ACS, each ant in the ant colony tries to find the best destination PMs for migrating VMs from overloaded or underloaded PMs. The proposed PSO‐ACS algorithm is experimented with PlanetLab real workload traces available in the CloudSim toolkit. The algorithm provides reduction in energy consumption, number of VM migrations, and Energy SLA Violation (ESV) metrics while maintaining QoS. In the best‐case scenario, the proposed method reduces the ESV metric by 28%, 27%, and 18% in comparison with other algorithms like LR, ACS, and PSO‐LR.
No evidence of EMAST in whole genome sequencing data from 248 colorectal cancers
Authors: Kondelin Johanna , Martin Samantha , Katainen Riku , Renkonen‐Sinisalo Laura , Lepistö Anna , Koskensalo Selja , Böhm Jan , Mecklin Jukka‐Pekka , Cajuso Tatiana , Hänninen Ulrika A. , Välimäki Niko , Ravantti Janne , Rajamäki Kristiina , Palin Kimmo , Aaltonen Lauri A. 
Published: February 2021

AbstractMicrosatellite instability (MSI) is caused by defective DNA mismatch repair (MMR), and manifests as accumulation of small insertions and deletions (indels) in short tandem repeats of the genome. Another form of repeat instability, elevated microsatellite alterations at selected tetranucleotide repeats (EMAST), has been suggested to occur in 50% to 60% of colorectal cancer (CRC), of which approximately one quarter are accounted for by MSI. Unlike for MSI, the criteria for defining EMAST is not consensual. EMAST CRCs have been suggested to form a distinct subset of CRCs that has been linked to a higher tumor stage, chronic inflammation, and poor prognosis. EMAST CRCs not exhibiting MSI have been proposed to show instability of di‐ and trinucleotide repeats in addition to tetranucleotide repeats, but lack instability of mononucleotide repeats. However, previous studies on EMAST have been based on targeted analysis of small sets of marker repeats, often in relatively few samples. To gain insight into tetranucleotide instability on a genome‐wide level, we utilized whole genome sequencing data from 227 microsatellite stable (MSS) CRCs, 18 MSI CRCs, 3 POLE‐mutated CRCs, and their corresponding normal samples. As expected, we observed tetranucleotide instability in all MSI CRCs, accompanied by instability of mono‐, di‐, and trinucleotide repeats. Among MSS CRCs, some tumors displayed more microsatellite mutations than others as a continuum, and no distinct subset of tumors with the previously proposed molecular characters of EMAST could be observed. Our results suggest that tetranucleotide repeat mutations in non‐MSI CRCs represent stochastic mutation events rather than define a distinct CRC subclass.
Response of three native grass species on dry tailings reclamation substrate amended with petroleum coke
Authors: Luna Wolter Gabriela L. , Dhar Amalesh , Naeth M. Anne 
Published: February 2021

AbstractSurface mining around the world has produced large quantities of waste materials with ecological impacts. Oil sands mining in Canada generates large volumes of petroleum coke and tailings every year, which are stockpiled in the mining areas and must be reclaimed through capping or used in reclamation substrates. A greenhouse study was conducted to determine whether substrates of various mixes of dry tailings (DT), tailings sand (TS), and peat mineral mix (PMM) with coke amendment would support emergence and growth of three grass species commonly used in land reclamation. After 16 wk in the greenhouse, plant performance varied with substrate and amendment. Treatment with DT/TS/PMM (50:25:25) with 40% coke had greatest cover, biomass, and density and the best plant health. Plant growth was inhibited in treatments with DT (100%) and coke (100%) due to high concentrations of hydrocarbons, undesirable exchangeable ions, and salinity that restricted soil water retention (gravimetric water content, hydraulic conductivity) relative to treatments with PMM. Agrostis scabra Willd. and Festuca saximontana. showed poor growth or did not survive on DT and DT/TS with coke. Elymus trachycaulus (Link) Gould ex Shinners performed better in all DT mixes and performed the best in DT/TS/PMM with 40% coke. Results from this study indicate that mixing with PMM could improve the reclamation potential of DT and coke.
Association of ADAM10 gene variants with sporadic Parkinson's disease in Chinese Han population
Authors: Zhou Miaomiao , Lin Yuwan , Lu Lin , Zhang Zhiling , Guo Wenyuan , Peng Guoyou , Zhang Wenlong , Zhu Ziting , Wu Zhuohua , Mo Mingshu , Yang Xinling , Zhu Xiaoqin , Chen Chaojun , Chen Xiang , Xu Pingyi 
Published: February 2021

AbstractBackgroundParkinson's disease (PD) is the second most common neurodegenerative disease worldwide. Genetic factors play important roles in PD risk. rs653765 and rs514049 of ADAM10 were reported to be associated with Alzheimer's disease (AD) in Caucasian population; however, the association of the two variants with PD in Chinese Han population remains unknown. The present investigation aimed to explore the possible association of ADAM10 variants with PD in Chinese Han population.MethodsWe enrolled 565 PD patients and 518 healthy controls to conduct a case–control study. DNA samples were extracted from peripheral blood leukocytes, and the genotypes were determined by utilization of MassARRAY platform. Plasma levels were measured by enzyme‐linked immunosorbent assay (ELISA).ResultsWe found CC genotype of rs514049 was associated with an increased risk of PD (OR (95% CI) = 3.776 (1.127–11.217), p = 0.018). The C allele frequency of rs514049 was significantly higher in PD group (OR (95% CI) = 1.328 (1.031–1.709), p = 0.028), especially in male subgroup (OR (95% CI) = 1.484 (1.053–2.092), p = 0.024). However, there was no significant difference in the genotype or allele frequencies for rs653765 within the groups. Plasma levels were significantly decreased in PD patients compared with controls (p < 0.001).ConclusionsOur data suggested that C allele of rs514049 in ADAM10 may increase the risk of PD in Chinese Han population, especially in males. The decreased plasma levels are probably involved in PD development.
A novel turn‐on fluorometric “reporter‐spacer‐receptor” chemosensor based on calix[4]arene scaffold for detection of cyanate anion
Authors: Bozkurt Selahattin , Halay Erkan , Durmaz Mustafa , Topkafa Mustafa , Ceylan Özgür 
Published: February 2021

AbstractHerein, a novel calix[4]arene compound, which was modified by the 2‐(2‐aminophenyl)benzothiazole fragment with cyanate recognition function was designed based on the reporter‐spacer‐receptor sensing system. The construction was done via two‐step reaction, and the desired sensor 4 was characterized by FT‐IR, 1H‐, 13C‐NMR, and fluorescence spectroscopy along with HRMS data. The sensor candidate showed distinct fluorometric cyanate detection by means of reporter feature of selected benzothiazole constituent. In the presence of cyanate, the sensor gave a turn‐on‐type fluorescence at 482 nm with a large stokes' shift. Furthermore, it was observed that our fluoroionophore 4 is highly selective toward cyanate over remaining anions such as sulfate, phosphate, fluoride, chloride, bromide, iodide, chlorate, and nitrate in 10% aqueous solution of DMSO. The 1:2 stoichiometric ratio of the 4‐cyanate complex was given the best fit with Job's plot based on the titration data. The association constant (Ka) of sensor 4 with cyanate is determined to be 1.64 × 105 M−2. The obtained limit of detection (LOD) value for cyanate anion, 312 nM, clearly revealed the remarkable sensitivity of the chemosensor 4. This supramolecular method provides a highly adaptive technique for the detection of cyanate and so cyanide ions by current international standard methods.
Surgical and oncological outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy at a nonacademic center: 25‐year experience
Authors: Nikiforchin Andrei , Gushchin Vadim , King Mary Caitlin , Baron Ekaterina , Nieroda Carol , Sittig Michelle , Sardi Armando 
Published: February 2021

AbstractBackgroundCytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is predominantly performed and studied in academic centers. While developing CRS/HIPEC programs in nonacademic hospitals can increase accessibility, its safety and oncological efficacy remains unclear. We evaluated CRS/HIPEC outcomes in a nonacademic setting.MethodsA single‐center descriptive study was conducted using a prospective database. Data of all CRS/HIPEC attempts in peritoneal surface malignancies (PSM) patients from October 1994 to November 2019 were extracted. Surgical and survival outcomes were measured. Center experience was assessed by quartiles of cases.ResultsOverall, 856 patients underwent 948 CRS/HIPEC attempts: 788 (83%) completed CRS/HIPECs, 144 (15%) aborted HIPECs, and 16 (2%) complete cytoreductions (CC‐0/1) without chemoperfusion. For completed CRS/HIPECs, median peritoneal cancer index was 24 (interquartile range: 10–33) and CC‐0/1 rate was 88%. Major complications occurred in 23.5% with 30‐ and 100‐day mortality of 1.0% and 2.3%, respectively. Median overall survival was 68 months (95% confidence interval [CI]: 50–86). Median progression‐free survival was 37 months (95%CI: 28–46). Incomplete cytoreduction and major complication rates decreased over time, while mortality remained low and constant.ConclusionsCRS/HIPEC at a nonacademic center with advanced surgical and auxiliary services is a safe option to treat PSM with favorable surgical and oncological outcomes.
Rapid and precise measurements of radon in water using a pulsed ionization chamber
Authors: Seo Junhyeong , Kim Guebuem 
Published: February 2021

AbstractRadon‐in‐air monitor (RAD7, Durridge Co.) has been widely used to measure 222Rn in water samples. RAD7 measures 222Rn via 218Po+ (t1/2 = 3.1 min), which is electrically attracted to a silicon alpha detector. In this study, a new method was developed for measuring 222Rn in water samples by modifying a commercially available pulsed ionization chamber (PIC, FT‐Lab Co.). The PIC detects and amplifies the electric pulses generated by microspace charges produced by 222Rn decay. Two passive PICs (volume: 2 × 400 mL) were combined and modified to form an active system (named Rn‐SNU) that continuously circulates air (~ 1 L min−1). Rn‐SNU is approximately seven to nine times more efficient than RAD7 and does not necessitate a delay of ~ 15 min to reach radioactive equilibrium between 222Rn and 218Po+. However, RAD7 is more accurate in discriminating 222Rn daughters, 218Po+ and 214Po+. In this study, 222Rn was successfully measured in coastal seawater samples using Rn‐SNU connected to a grab bottle. Our results suggest that 222Rn measurements in water samples can be conducted more efficiently and rapidly with an Rn‐SNU than with other widely used instruments and methods.
The multiple mediating effects of cancer threat appraisal and quality of life on the association between mindfulness and depression for colorectal cancer survivors
Authors: Chen Li‐Ting , Cheng Chih‐Tao , Huang I‐ping , Chang Jen‐Ho , Chang Nien‐Tzu , Hsiao Fei‐Hsiu 
Published: February 2021

AbstractObjectiveThis study explored the multiple mediating effects of cancer threat appraisal, functional status, and symptom distress on the association between mindfulness and depression in colorectal cancer (CRC) patients at the transition stage after completing cancer treatments.MethodsA total of 90 CRC survivors who received cancer treatments within 3 months participated in this cross‐sectional study. The functional status and symptom distress (EORTC‐C30 and EORTC CR29), dispositional mindfulness (Five Facet Mindfulness Questionnaire), cancer threat appraisal ( Constructed Meaning Scale), and depressive symptoms (Beck Depression Inventory‐II scale) were collected. The mediation and moderation analyses were conducted using the PROCESS macros for SPSS.ResultsSurvivors' dispositional mindfulness (γ = −0.49, p < 0.001) and cancer threat appraisal (γ = −0.59, p < 0.001) were significantly associated with depressive symptoms. Simple mediation analysis indicated that cancer threat appraisal mediated the relationship between dispositional mindfulness and depression (β = −0.02, 95% CI = −0.04 to −0.001). The multiple mediated analysis identified the path between dispositional mindfulness and depression via cancer threat appraisal and colorectal symptom distress (β = −0.01, 95% CI = −0.03 to −0.01). In the mediated moderation model, the path between dispositional mindfulness and depression via colorectal function was moderated by cancer threat appraisal (β = −0.02, 95% CI = −0.05 to −0.004).ConclusionsThe two cognitive mechanisms of reducing CRC survivors' depression are as follows: (1) dispositional mindfulness reducing the appraisal of cancer as a threat and increasing positive perceptions of CRC symptoms and (2) the cancer threat appraisal buffered the impacts of CRC's mindfulness and colorectal function on depressive symptoms. Developing mindfulness with cognitive training is recommended for improving depressive symptoms among CRC patients in the transition period.
Dependence of tropical cyclone intrinsic intensity variability on the large‐scale environment
Authors: Keshavamurthy Kushal , Kieu Chanh 
Published: February 2021

AbstractThis study examines the dependence of tropical cyclone (TC) intrinsic intensity variability on the large‐scale environment. Using idealized simulations with the Hurricane Research and Forecasting (HWRF) model, the growth of TC intensity errors and the subsequent saturation of intensity errors at the mature stage are quantified for a range of environmental conditions. Among several factors, it is found that sea‐surface temperature (SST) and tropospheric static stability are the two main ones affecting the growth rate and saturation of TC intensity errors, with a larger error saturation at maximum intensity equilibrium and a faster error growth rate during rapid intensification for a warmer SST or less stable troposphere. Results from this study highlight the fundamental characteristics of TC intensity predictability, which appears to vary with environmental conditions, instead of being a universal measure for TCs in all ocean basins. These results also suggest a limit on TC intensity forecast accuracy that is governed by the large‐scale environment, which needs to be taken into consideration for future TC model development.
Unexplained infertility categorization based on female laparoscopy and total motile sperm count, and its impact on cumulative live‐births after one in‐vitro fertilization cycle. A retrospective cohort study involving 721 cycles
Authors: Satwik Ruma , Kochhar Mohinder 
Published: February 2021

AbstractPurposeTo determine how subcategorizing unexplained infertility based on female laparoscopy and total‐motile‐sperm‐count assessment would impact cumulative live‐births after one in‐vitro fertilization (IVF) cycle.MethodsSeven hundred twenty one IVF cycles from Jan 2014‐April 2019 performed at a single‐center were retrospectively analyzed. Couples with unexplained infertility having normal uterine and endometrial morphology were subcategorized into three cohorts, UI (1): those with no tuboperitoneal pathology on laparoscopy and total‐motile‐sperm‐count (TMSC) ≧20 million: n = 103; UI (2): tuboperitoneal pathology on laparoscopy or TMSC <20 million, n = 86; and UI(3): tuboperitoneal status not known: n = 114. Controls were severe male factor, bilateral tubal block, and grade 3/4 endometriosis: n = 418. Primary Outcome was cumulative‐live‐birth‐per‐initiated‐IVF cycle (CLBR). Odds ratio for live‐births were adjusted for confounding factors.ResultsThe CLBR in UI1 cohort was significantly lower than controls (29.1% vs 39; OR = 0.62; 95%CI = 0.39‐0.98; P = .04); but similar in UI2 and UI3 vs. controls. (37.2% vs 39.95%; OR = 0.89, 95%CI = 0.55‐1.44; P = .89) and (38.6% vs 39.95%; OR = 0.98, 95%CI = 0.64‐1.55; P = .98). After adjusting for age, infertility duration, past live‐births, and AMH, the adjusted odds for CLBR in UI1 was 0.48 (95%CI = 0.28‐0.82; P = .007).ConclusionsUnexplained infertility when defined after a normal laparoscopy and TMSC significantly lowered cumulative‐live‐births‐per‐initiated‐IVF cycle when compared with traditional diagnosis of tubal, endometriosis, or male factor infertility. In UI subcategory with abnormal laparoscopy or TMSC, CLBR remained unaffected. This information could be useful for counseling couples prior to IVF. Large‐scale prospective studies are needed to confirm this observation.
A frontier‐based managerial approach for relative sustainability performance assessment of the world's airports
Authors: Kucukvar Murat , Alawi Khalel Ahmed , Abdella Galal M. , Bulak Muhammet Enis , Onat Nuri C. , Bulu Melih , Yalçıntaş Murat 
Published: February 2021

AbstractThe sustainability impact of air transportation has become crucial to communities. Airports around the world are forced to be transparent with the society and to declare their sustainability results. As the sustainability goals and objectives and due to its multi‐dimension aspects that are needed to be decided of and subsequently improved, the decision has been taken, and the parameters have been selected due to its significance in this field. This research presents a managerial approach combining the optimization‐based frontier approach with the Global Report Initiative's comprehensive sustainability database for selected 30 major international airports based on data availability. In this regard, eco‐efficiency analysis is carried out with four different models using input‐oriented modeling with multiple undesirable environmental inputs (energy, carbon, water, and waste) and desirable outputs (revenue, passenger and employment) to compare efficiency and sustainability levels of airports in different contexts. Finally, performance improvement targets of each environmental indicators are presented for the airports. These comparative models reveal different frontier airports, which provide the opportunity to analyze diversified reference points for the same decision‐making unit. The presented statistical study has shown that San Francisco, Hong Kong, Hamad International Airport are the most efficient airports in terms of overall sustainability performance based on collected data and selected indicators. The authors also concluded that there is a discrepancy in sustainability data reporting between airports, and there is a need for collecting complete, consistent and real‐time social, environmental, economic, and governance data, to better compare and evaluate the performance of each airport from a sustainability perspective.
Verification algebra for multi‐tenant applications in VaaS architecture
Authors: Hu Kai , Wan Ji , Luo Kan , Xu Yuzhuang , Cheng Zijing , Tsai Wei‐Tek 
Published: February 2021

SummaryThis paper proposes an algebraic system, verification algebra (VA), for reducing the number of component combinations to be verified in multi‐tenant architecture (MTA). MTA is a design architecture used in SaaS (Software‐as‐a‐Service) where a tenant can customize its applications by integrating services already stored in the SaaS databases or newly supplied services. Similar to SaaS, VaaS (Verification‐as‐a‐Service) is a verification service in a cloud that leverages the computing power offered by a cloud environment with automated provisioning, scalability and service composition. In VaaS architecture, however, there is a challenging problem called ‘combinatorial explosion’ that it is difficult to verify a large number of compositions constructed by both quantities of components and various combination structures even with computing resources in cloud. This paper proposes rules to emerge combinations status for future verification, on the basis of the existing results. Both composition patterns and properties are considered and analysed in VA rules.
Prevalence and antimicrobial susceptibility profiles of non‐typhoidal Salmonella isolated from chickens in Rajshahi, Bangladesh
Authors: Sarker Bindu R. , Ghosh Sumon , Chowdhury Sukanta , Dutta Avijit , Chandra Deb Liton , Krishna Sarker Bidhan , Sultana Tania , Mozaffor Hossain Khandoker Mohammad 
Published: February 2021

AbstractSalmonellosis in poultry is an important disease that seriously impedes the development of the poultry industry. The increased resistance to antimicrobials against Salmonella has been a major public health concern worldwide. We conducted a study from January to June 2016 in and around the Rajshahi district of Bangladesh on the commercial chicken to isolate, identify and characterize poultry‐specific Salmonella, to assess the potential risk factors and to determine the antimicrobial resistance pattern of the isolates. The overall prevalence of Salmonella enterica was 41% (49/120) [95% CI: 31.95%–50.17%] with 41.7% in broiler chicken (25/60) [95% CI: 29.06%–55.12%] and 40% in layer chicken (24/60, 40%) [95% CI: 27.56%–53.46%]. Samples collected from Rajshahi city (OR = 1.37, 95% CI: 0.50–3.73) and Puthia Upazila (OR = 1.51, 95% CI: 0.56–4.12) were more likely to be positive for Salmonella than Charghat Upazila. Salmonella detection was 1.3 times higher in chicken, providing loose feed than those provided ready feed. All the isolates fermented dextrose, maltose and mannitol with the production of acid and gas, but did not ferment sucrose and lactose. The isolates showed catalase, MR, citrate utilization test and TSI agar test positive, but indole and V‐P tests negative. Salmonella isolates were sensitive to ciprofloxacin (90%), gentamycin (80%), amoxicillin (75%), streptomycin (70%), ampicillin (45%) and sulfamethoxazole‐trimethoprim (45%), whereas highly resistant to penicillin (100%) and nalidixic acid (100%) followed by sulfamethoxazole‐trimethoprim (55%), ampicillin (40%) and amoxicillin (25%). Salmonella enterica is endemic in commercial chicken production in Bangladesh with high prevalence. A considerable proportion of Salmonella isolates was found to be resistant to the majority of the common antimicrobial drugs. A good biosecurity system could be effective for the reduction of Salmonella. It is necessary to obtain universal commitments to establish prudent antibiotic use policies.