bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Baseline Meniscal Symptoms and Outcomes of Operative and Nonoperative Treatment of Meniscal Tear in Patients With Osteoarthritis
Authors: MacFarlane Lindsey A. , Yang Heidi , Collins Jamie E. , Brophy Robert H. , Cole Brian J. , Spindler Kurt P. , Guermazi Ali , Jones Morgan H. , Mandl Lisa A. , Martin Scott , Marx Robert G. , Levy Bruce A. , Stuart Michael , Safran‐Norton Clare , Wright John , Wright Rick W. , Losina Elena , Katz Jeffrey N. 
Published: March 2021

ObjectivePatients with meniscal tears reporting meniscal symptoms such as catching or locking have traditionally undergone arthroscopy. The present study was undertaken to investigate whether patients with meniscal tears who report meniscal symptoms have greater improvement with arthroscopic partial meniscectomy (APM) than physical therapy (PT).MethodsWe used data from the Meniscal Tear in Osteoarthritis Research (MeTeOR) trial, which randomized participants with knee osteoarthritis (OA) and meniscal tear to APM or PT. The frequency of each meniscal symptom (clicking, catching, popping, intermittent locking, giving way, swelling) was measured at baseline and 6 months. We used linear regression models to determine whether the difference in improvement in Knee Injury and Osteoarthritis Outcome Score (KOOS) pain score at 6 months between patients treated with APM versus PT was modified by the presence of each meniscal symptom. We also determined the percentage of participants with resolution of meniscal symptoms by treatment group.ResultsWe included 287 participants. The presence (versus absence) of any of the meniscal symptoms did not modify the improvement in KOOS pain score between APM versus PT by >0.5 SD (all P interaction >0.05). APM led to greater resolution of intermittent locking and clicking than PT (locking 70% versus 46%, clicking 41% versus 25%). No difference in resolution of the other meniscal symptoms was observed.ConclusionMeniscal symptoms were not associated with improved pain relief. Although symptoms of clicking and intermittent locking had a greater reduction in the APM group, the presence of meniscal symptoms in isolation should not inform clinical decisions surrounding APM versus PT in patients with meniscal tear and knee OA.
Photocatalytic Deoxygenative Carboimination towards Functionalized Pyrrolines by Using Unstrained γ,δ‐Unsaturated Oximes
Authors: Zhang Min , Zhang Zhijie , He Yangsen , Zou Ting , Qi Zhongyu , Fu Qiang , Wei Jun , Lu Ji , Wei Siping , Yi Dong 
Published: March 2021

AbstractPhotocatalytic deoxygenative carboimination of unstrained γ,δ‐unsaturated oximes with π‐acceptors including trifluoromethyl alkenes, 1‐trifluoromethyl‐1,3‐butadienes, gem‐difluoroalkenes, acrylates, and styrenes has been achieved which provides an efficient and mild approach to construct structurally diverse and highly functionalized pyrrolines with good functional group tolerance. Importantly, upon utilization of trifluoromethyl alkenes as the coupling partners, the developed protocol not only allows the introduction of the extremely valuable gem‐difluoroalkene functionality and pyrroline moiety into one molecule, but could also further transform the resulting gem‐difluoroalkene‐functionalized pyrrolines to the architecturally intriguing indolizine alkaloids via oxidation/reduction and sequential C−F bond cleavage. The mechanistic studies indicated that a free‐radical and anionic process was probably involved in this photocatalytic deoxygenative transformation.magnified image
Programmed Synthesis of Hepta‐Differentiated β‐Cyclodextrin: 1 out of 117655 Arrangements
Authors: Liu Jiang , Wang Bo , Przybylski Cédric , Bistri‐Aslanoff Olivia , Ménand Mickaël , Zhang Yongmin , Sollogoub Matthieu 
Published: March 2021

AbstractCyclodextrin poly‐functionalization has fueled progress in their use in multiple applications such as enzyme mimicry, but also in the polymer sciences, luminescence, as sensors or for biomedical applications. However, regioselective access to a given pattern of functions on β‐cyclodextrin is still very limited. We uncover a new orienting group, the thioacetate, that expands the toolbox available for cyclodextrin poly‐hetero‐functionalization using diisobutylaluminum hydride (DIBAL‐H) promoted debenzylation. The usefulness of this group is illustrated in the first synthesis of a precisely hepta‐hetero‐functionalized β‐cyclodextrin. By way of comparison, a random hepta‐functionalization would give 117655 different molecules. This synthesis is not simply the vain quest for the Holy Grail of CD hetero‐functionalization, but it illustrates the versatility of the DIBAL‐H oriented hetero‐functionalization strategy, opening the way to a multitude of useful functionalization patterns for new practical applications.
Organosulfide‐Based Deep Eutectic Electrolyte for Lithium Batteries
Authors: Song Jiahan , Si Yubing , Guo Wei , Wang Donghai , Fu Yongzhu 
Published: March 2021

AbstractDeep eutectic electrolytes (DEEs) are a new class of electrolytes with unique properties. However, the intermolecular interactions of DEEs are mostly dominated by Li⋅⋅⋅O interactions, limiting the diversity of chemical space and material constituents. Herein, we report a new class of DEEs induced by Li⋅⋅⋅N interactions between 2,2′‐dipyridyl disulfide (DpyDS) and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI). The strong ion‐dipole interaction triggers the deep eutectic phenomenon, thus liberating the Li+ from LiTFSI and endowing the DEEs with promising ionic conductivity. These DEEs show admirable intrinsic safety, which cannot be ignited by flame. The DEE at the molar ratio of DpyDS:LiTFSI=4:1 (abbreviated as DEE‐4:1) is electrochemically stable between 2.1 and 4.0 V vs. Li/Li+, and exhibits an ionic conductivity of 1.5×10−4 S cm−1 at 50 °C. The Li/LiFePO4 half cell with DEE‐4:1 can provide a reversible capacity of 130 mAh g−1 and Coulombic efficiency above 98 % at 50 °C.
Rhoda‐Electrocatalyzed Bimetallic C−H Oxygenation by Weak O‐Coordination
Authors: Tan Xuefeng , Massignan Leonardo , Hou Xiaoyan , Frey Johanna , Oliveira João C. A. , Hussain Masoom Nasiha , Ackermann Lutz 
Published: March 2021

AbstractRhodium‐electrocatalyzed arene C−H oxygenation by weakly O‐coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C−H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation‐induced C−H activation by a bimetallic rhodium catalysis manifold.
Reexamination of the “uneven route” account of loss aversion
Authors: Sui Xiao‐Yang , Huang Yuan‐Na , Xu Ming‐Xing , Kuang Yi , Shen Si‐Chu 
Published: March 2021

AbstractThe “uneven route” accountpredicts how and why loss aversion appears in human behavior. The account assumes that loss aversion occurs when the routes (the number of transitions of the same possession) for losses are greater than those for gains. The present study manipulated the uneven route account and then reexamined the account by using more harsh and unfavorable experimental conditions. Results of four experiments and a mini meta‐analysis consistently showed that the modal choice supporting the uneven route account was robust to variations in the experimental design to the magnitude of payoffs and to the index of measuring loss aversion. That is, loss aversion disappeared in the tax refund versus tax paid scenario compared with the win money versus lose money scenario. These results are expected to enrich the underlying mechanism of loss aversion and attract the interest of fellow researchers to conduct further research to see which account can better explain the loss aversion.
Optimizing recombineering in Corynebacterium glutamicum
Authors: Li Cheng , Swofford Charles A. , Rückert Christian , Sinskey Anthony J. 
Published: March 2021

AbstractOwing to the increasing demand for amino acids and valuable commodities that can be produced by Corynebacterium glutamicum, there is a pressing need for new rapid genome engineering tools that improve the speed and efficiency of genomic insertions, deletions, and mutations. Recombineering using the λ Red system in Escherichia coli has proven very successful at genetically modifying this organism in a quick and efficient manner, suggesting that optimizing a recombineering system for C. glutamicum will also improve the speed for genomic modifications. Here, we maximized the recombineering efficiency in C. glutamicum by testing the efficacy of seven different recombinase/exonuclease pairs for integrating single‐stranded DNA and double‐stranded DNA (dsDNA) into the genome. By optimizing the homologous arm length and the amount of dsDNA transformed, as well as eliminating codon bias, a dsDNA recombineering efficiency of 13,250 transformed colonies/109 viable cells was achieved, the highest efficiency currently reported in the literature. Using this optimized system, over 40,000 bp could be deleted in one transformation step. This recombineering strategy will greatly improve the speed of genetic modifications in C. glutamicum and assist other systems, such as clustered regularly interspaced short palindromic repeats and multiplexed automated genome engineering, in improving targeted genome editing.
A Thorough Study on the Photoisomerization of Ferulic Acid Derivatives
Authors: Moni Lisa , Banfi Luca , Basso Andrea , Mori Alessia , Risso Federica , Riva Renata , Lambruschini Chiara 
Published: March 2021

AbstractA thorough study on the (E) to (Z) photoisomerization of ferulic acid derivatives (esters, amides of all types, and ketones) was carried out. At the photostationary state, only aliphatic or benzylic tertiary amides reach a nearly complete conversion of (E) isomers into the (Z) ones, whereas for esters, primary and secondary amides or aromatic tertiary amides mixtures of (Z)/(E) ranging from 7 : 93 to 72 : 28 are observed. Ketones show rather limited photoisomerization. However, (Z) ketones may be obtained by the reaction of organometal compounds with an isomerized (Z) Weinreb amide.
Wideband Minkowski fractal antenna using complementary split ring resonator in modified ground plane for 5G wireless communications
Authors: Ohi Md. Ashfaq Rahman , Hasan Zahid , Faruquee Shadman Fuad Bin , Kawsar Abdul Al Mamun , Ahmed Anis 
Published: March 2021

AbstractIn this paper, the enhancement of gain and bandwidth of a Minkowski fractal antenna (MFA) with defected ground structure is investigated. The antenna characteristics are studied for first and second iterations by considering complementary split ring resonators in the L‐shaped modified ground plane. The dimensions of the MFA are optimized with computer simulation technology software and the fabricated antenna characteristics are measured using Vector Network Analyzer and Wave and Antenna Training System. From the simulation, the maximum gain of our proposed antenna has been found 5.2 dB. Both bandwidths obtained from simulation and measurement exceed 2 GHz. The results of simulation are in good agreement with measured ones. This proposed antenna is suitable for the applications of various 5G wireless communications.
A multidimensional computational exploration of congenital myasthenic syndrome causing mutations in human choline acetyltransferase
Authors: Janežič Matej , Dileep Kalarickal V. , Zhang Kam Y. J. 
Published: March 2021

AbstractMissense mutations of human choline acetyltransferase (CHAT) are mainly associated with congenital myasthenic syndrome (CMS). To date, several pathogenic mutations have been reported, but due to the rarity and genetic complexity of CMS and difficult genotype–phenotype correlations, the CHAT mutations, and their consequences are underexplored. In this study, we systematically sift through the available genetic data in search of previously unreported pathogenic mutations and use a dynamic in silico model to provide structural explanations for the pathogenicity of the reported deleterious and undetermined variants. Through rigorous multiparameter analyses, we conclude that mutations can affect CHAT through a variety of different mechanisms: by disrupting the secondary structure, by perturbing the P‐loop through long‐range allosteric interactions, by disrupting the domain connecting loop, and by affecting the phosphorylation process. This study provides the first dynamic look at how mutations affect the structure and catalytic activity in CHAT and highlights the need for further genomic research to better understand the pathology of CHAT.
Improvement of swallowing‐related muscle mass assessed by ultrasonography in malnourished patient with Wallenberg syndrome: A case report
Authors: Wakabayashi Hidetaka , Kishima Masako , Itoda Masataka 
Published: March 2021

AbstractWe experienced a malnourished 62‐year‐old male patient with Wallenberg syndrome whose swallowing‐related muscle mass was shown to improve on ultrasound following aggressive nutritional therapy used to improve malnutrition. Dysphagia improved from no oral intake at admission to regular oral intake at discharge by aggressive rehabilitation nutrition. Rate increases in body weight, skeletal muscle index, and coronal cross‐section of geniohyoid muscle area assessed by ultrasound during the 131 days of hospitalization were 15%, 21%, and 33%, respectively. Aggressive nutritional therapy, aimed at improving malnutrition, can improve swallowing‐related muscle mass. Ultrasonography of the swallowing‐related muscles over time is useful in assessing dysphagia.
Comorbid personality difficulties are not associated with poorer outcomes for online cognitive behaviour therapy for symptoms of anxiety and depression
Authors: Mahoney Alison E.J. , Haskelberg Hila , Mason Elizabeth , Millard Michael , Newby Jill 
Published: March 2021

AbstractLittle is known about the prevalence and impact on treatment of comorbid personality disorders for adults undertaking online cognitive behaviour therapy (internet‐delivered or internet‐based cognitive behaviour therapy (iCBT)) for anxiety and depressive disorders. This study explored how common comorbid personality difficulties were in a large sample of consecutive patients (N = 1 132) seeking iCBT for their symptoms of anxiety and depression in routine care settings. Patients completed the Standardized Assessment of Personality‐abbreviated Scale Self‐Report prior to commencing an iCBT programme, as well as completing assessments of anxiety and depression symptom severity and psychological distress pre‐iCBT and post‐iCBT. Consistent with previous studies, a high proportion of the sample (62.6%) reported experiencing comorbid personality difficulties. However, comorbid personality difficulties were not significantly associated with poorer treatment adherence or higher post‐treatment symptom severity or psychological distress (controlling for baseline symptom severity, demographic characteristics and treatment variables). Current findings support an inclusive approach to iCBT provision where comorbid personality difficulties do not appear to be a contraindication for treatment. © 2021 John Wiley & Sons, Ltd.
Clinical use of the modified shuttle test in children with cystic fibrosis: Is one test sufficient?
Authors: Leite Luanna Rodrigues , Queiroz Karen Caroline Vasconcelos , da Silva Franciely Helena , Coelho Cristiane Cenachi , Donadio Márcio Vinícius Fagundes , Aquino Evanirso da Silva 
Published: March 2021

AbstractObjectiveTo evaluate the reproducibility of the modified shuttle test (MST) and to determine whether the test needs to be performed more than once to assess the exercise capacity of children and adolescents with cystic fibrosis (CF).MethodsThis was a longitudinal study including patients diagnosed with CF aged more than 6 years. The participants were followed for a period of 9 months and were evaluated at three different time points (visits 1, 2, and 3). Spirometric, anthropometric, clinical, and genetic data were collected, and two MSTs were performed at each visit.ResultsForty‐eight clinically stable volunteers with a mean age of 10.1 ± 2.7 years were initially included. The reproducibility of the test was evaluated using the distance achieved (DA) as the main variable. There were no significant differences in the DA (visit 1, p = .23; visit 2, p = .24; visit 3, p = .85), baseline heart rate (HR) (visit 1, p = .35; visit 2, p = .20; visit 3, p = .98), and peak HR (visit 1, p = .16; visit 2, p = .94; visit 3, p = .23) between the tests performed at each visit. The test‐retest reliability demonstrated a high intraclass correlation coefficient at all visits (visit 1, 2, and 3: 0.83, 0.90, and 0.80, respectively) and the variation in HR was the main factor associated with the DA in the MST over time.ConclusionThe MST was found to be a reproducible and reliable test. The data presented here support the use of a single MST to evaluate and monitor exercise capacity of patients with CF during clinic visits.
Real‐Time Plume Velocity Measurement of Solid Propellant Rocket Motors Using TDLAS Technique
Authors: Song Anchen , Qin Zhao , Li Junwei , Li Meng , Huang Ke , Yang Yanjing , Wang Ningfei 
Published: March 2021

AbstractAccurate measurement of plume velocity plays an important role in investigation of rocket motors, and the plume velocity is an indicator of energy level of solid propellants. A method based on laser Doppler effect using tunable diode laser absorption spectroscopy (TDLAS) is employed in this study. The absorption spectrum of water vapor feature at 1391.7 nm is utilized to measure the plume velocity. Three solid propellants, double‐base (DB), composite modified double‐base (CMDB), and nitrate ester plasticized polyether (NEPE) i. e., are burned in a motor with an internal diameter of 50 mm and their plume velocities are measured with scanned‐WMS‐2f technique. Afterburning reactions in the plume are numerically simulated. The simulations can provide insight into the nuances in measured TDLAS results and give confidence in the result. The results show that TDLAS is a good method to measure plume velocity. The relative standard deviation of the measurements is less than 4 %. The difference between the measured velocity and the simulated one is less than 8.25 %. Additionally, it is found that NEPE has the largest plume velocity, and the velocity of DB is the lowest. Uncertainties of velocity measurement using TDLAS are analyzed. Measurement uncertainty comes from velocity non‐uniformity in the direction perpendicular to the plume direction. Furthermore, it can be found that it is better to put the measurement position close to the nozzle exit to reduce measurement errors.
Acridine‐1,8‐diones: Synthesis and Biological Applications
Authors: Sahiba Nusrat , Sethiya Ayushi , Soni Jay , Agarwal Shikha 
Published: March 2021

AbstractThe unpretentious features of acridine‐1,8‐dionesviz. presence of N‐heteroatom, electronic behavior, acridine ring skeleton and wide possibilities of diversified substitution, bichromophoric structure and interaction ability with various proteins, make them an interesting scaffold of heterocyclic, medicinal and industrial chemistry. A tremendous development in the field of acridinediones in terms of synthetic strategies, bioactivity, industrial and other applicability has been explored in past four decades. In this perspective, an overview has been given on the state‐of‐art discoveries for the synthesis and biological applications of acridine‐1,8‐diones from 1980 to 2020. The study highlighted the history, chemistry and properties of these derivatives and provided deep insights into the synthetic protocols using various catalysts and techniques like nano‐catalyst, ionic‐liquids, microwave, ultrasound etc. under varied conditions along with biological activity against many lethal diseases. Finally, the respective prospects and limitations to these systems have been addressed. Furthermore, attempts have been done to bring many outstanding researches together and express the significance of acridine‐1,8‐diones through several aspects. We hope that the article shall deliver an impetus to explore further the synthetic values and mechanistic puzzles of acridinedione moiety and to design more promising hybrid multi‐targeted drugs and other industrial composites for the goodness of humanity
Copper‐Catalyzed Remote C5‐Selective Chlorination of 8‐Amidoquinolines Using Sulfonyl Chlorides as Cl Source
Authors: Zhang Han , Xu Miao , Liu Ningning , Yang Fanzhi 
Published: March 2021

AbstractSulfonyl chloride has been rarely used as Cl source in transition metal‐catalyzed C−H functionalizations. We report the unprecedented copper‐catalyzed remote C5‐chlorination of substituted 8‐amidoquinolines with sulfonyl chloride under 1 atm oxygen. 10 sulfonyl chlorides and 15 substituted 8‐amidoquinolines were tested, generating moderate to high yields. The catalytic system showed high regio‐selectivity, as well as good functional group tolerance.
An NADPH‐independent mechanism enhances oxidative and nitrosative stress tolerance in yeast cells lacking glucose‐6‐phosphate dehydrogenase activity
Authors: Yoshikawa Yuki , Nasuno Ryo , Takagi Hiroshi 
Published: March 2021

AbstractThe reduced form of nicotinamide adenine dinucleotide phosphate (NADPH), which is required for various redox systems involving antioxidative stress enzymes, is thus important for stress tolerance mechanisms. Here, we analyzed the stress response of the NADPH‐depleted cells of Saccharomyces cerevisiae. A cell viability assay showed that the NADPH depletion induced by disruption of the ZWF1 gene encoding glucose‐6‐phosphate dehydrogenase, which is the major determinant of the intracellular NADPH/NADP+ ratio, enhanced the tolerance of S. cerevisiae to both oxidative and nitrosative stresses. The subsequent analyses demonstrated that the antioxidative transcriptional factor Yap1 was activated and the cytosolic catalase Ctt1, whose expression is regulated by Yap1, was upregulated in zwf1Δ cells irrespective of the presence or absence of stress stimuli. Moreover, deletion of the YAP1 or CTT1 gene inhibited the increased stress tolerance of zwf1Δ cells, indicating that Ctt1 dominantly contributed to the higher stress tolerance of zwf1Δ cells. Our findings suggest that an NADPH‐independent mechanism enhances oxidative and nitrosative stress tolerance in ZWF1‐lacking yeast cells.
The dressing method as non linear superposition in sigma models
Authors: Katsinis Dimitrios , Mitsoulas Ioannis , Pastras Georgios 
Published: March 2021

Abstract
We apply the dressing method on the Non Linear Sigma Model (NLSM), which describes the propagation of strings on ℝ × S2, for an arbitrary seed. We obtain a formal solution of the corresponding auxiliary system, which is expressed in terms of the solutions of the NLSM that have the same Pohlmeyer counterpart as the seed. Accordingly, we show that the dressing method can be applied without solving any differential equations. In this context a superposition principle emerges: the dressed solution is expressed as a non-linear superposition of the seed with solutions of the NLSM with the same Pohlmeyer counterpart as the seed.