bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital skills, access and motivation to use e-services
Authors: González-Zabala Mayda Patricia , Galvis-Lista Ernesto Amaru , Sánchez-Torres Jenny Marcela 
Published: September 2021

This paper presents a study on digital skills, access and motivations to use or not e-services, made to students admitted to a technological career at the Universidad Distrital Francisco José de Caldas. The objective was to establish the previous knowledge in the digital area before beginning the education process offered by the university. A methodology proposed was: i) to determine the context, ii) data collection, and iii) reports generation and analysis of results. The main results obtained were: The characterization of the population under study, identify medium-high levels in the skills associated with knowledge of requirements for Internet access, search and use of online forms, and a medium-low level in recognition of secure environments to make transactions. In addition, it was found that 97% of the population access digital services because they are user-friendly, while distrust, lack of interest and ignorance about the digital service offer are the reasons that usually limit access. Regarding the use of services, 100% of the population use communication and entertainment services, 71.6% have used online training services, and 44.8% have searched for work online.
Hacia un estado del arte sobre la infancia contemporánea en Colombia, 2001-2018
Authors: Pardo Quevedo Diana Carolina 
Published: September 2021

Este artículo desarrolla los antecedentes del proyecto de tesis doctoral “el discurso de las nuevas infancias en la sociedad colombiana entre 2001-2018” cuyo objetivo es establecer la manera como los discursos institucionales y no institucionales configuran las nuevas infancias a partir de las transformaciones que han vivido la familia, la escuela y los medios de comunicación, desde el enfoque genealógico-arqueológico de investigación propuesto por Michel Foucault a partir del archivo documental sobre las tensiones de la infancia contemporánea a partir de tres frentes de trabajo: desde la perspectiva anglosajona y europea; en segundo lugar, la infancia en el contexto latinoamericano; y por último la infancia desde perspectiva académica colombiana. Frente a los resultados estos se expresan en términos conceptuales sobre las nuevas infancias atravesadas por los medios de comunicación, las nuevas tecnologías, las plataformas digitales o virtuales, las redes sociales, y la economía del consumo.
Faktor-Faktor yang Berhubungan dengan Ketepatan Waktu Vaksinasi Meningitis pada Jamaah Umrah (Studi di Kota Bengkulu)
Authors: Heriansyah Ernawati , Udiyono Ari , Martini Martini , Saraswati Lintang Dian 
Published: September 2021

Background: Meningococcal meningitis is a disease with high morbidity and mortality which, if left untreated, 100% will end in death. Meningitis vaccination is a way to prevent transmission of meningitis in high-risk groups such as Umrah pilgrims. As many as 26.69% of Umrah pilgrims in Bengkulu were late in conducting the meningitis vaccination.Methods: Used is analytic observational research with cross sectional approach. The research sample of 122 people with purposive sampling. Data processing was performed by chi square test by looking at the value of continuity correction and pearson chi-square with α=0.05.Result: There is a significant relationship between the level of knowledge about the time of meningitis vaccination, (p=0,000) and the perseption of role of umrah travel agency (p=0,023) with the timeliness of vaccination. There was no relationship between age (p= 0,328), sex (p=0,998), level of education (p=0,868), type of work (p=1,000), level of knowledge about meningitis (p=0,477), level of knowledge about vaccination meningitis (p=0,903), family support (p=0,083) and distance access to health services (p=0,996) with timely meningitis vaccination in Umrah pilgrims.Conclusion : Knowledge about the timing of vaccination and the perseption of role of umrah travel agency are the main determining factors of the accuracy of meningitis vaccination in Umrah pilgrims.
Prevalence of Genu Valgum in Children Aged 10-12 Years with Excessive Body Weight (Overweight/Obesity) in Sanur Kaja Village, Denpasar
Authors: Putri Vidya Rahmayunissa Swandi , Tianing Ni Wayan , Indrayani Agung Wiwiek , Wibawa Ari , Thanaya Sayu Aryantari Putri 
Published: September 2021

Background: Overweight/obesity is a global health problem, both in developed and developing countries and the number of overweight/obese people increases every year. Being overweight during childhood increases the risk of obesity in adulthood and can lead to musculoskeletal disorders, one of which is genu valgum. The purpose of this study was to determine the prevalence of genu valgum in children aged 10-12 years who are overweight/obese in Sanur Kaja Village, Denpasar.Methods: This study was an observational study with a cross-sectional design conducted at elementary schools in Sanur Kaja Village in April 2019. The sampling technique used was purposive sampling. A total of 78 children were included in this study. The univariate analysis in this study was genu valgum, overweight/obesity, age, and gender.Result: The prevalence of genu valgum in children aged 10-12 years in Sanur Kaja Village was 46.7% in overweight children and 53.3% in obese children, with 30 people (38.5%) experiencing genu valgum out of the total sample of 78 people (100%).Conclusion: Based on the result of this study, the incidence of genu valgum was higher in children aged 10-12 years who were obese compared to children with overweight body mass index. It is recommended that children who are obese and overweight to control their eating patterns, maintain normal body weight, and do enough physical activity.
Analisis Faktor Predisposing Terhadap Pemanfaatan Posyandu Balita di Wilayah Kerja Puskesmas Tegal Binangun Kota Palembang
Authors: Syarkowi Citrasari , Misnaniarti Misnaniarti , Zulkarnain M. 
Published: September 2021

Background: The proportion of Posyandu utilization by infants decreases with age of the child. Tegal Binangun Puskesmas has the lowest coverage of posyandu visits (D / S), amounting to 66.30% of 41 puskesmas in Palembang..Methods: An analytical research was conducted with cross sectional design in December 2019 - February 2020. The population of the study was 1,909 children under five years old in the working area of Tegal Binangun Public Health Center in Palembang. The research sample was mothers of toddlers 12 - 59 months in the working area of the Tegal Binangun Public Health Center in Palembang. 189 samples were selected by proportional random sampling. Data collection instruments are data collection papers that contain research variables. Data is taken from questionnaires about respondents' predisposing factors and direct observation of posyandu register books and KIA books. Data were analyzed using chi-square and logistic regression.Result: 153 respondents (81%) with low use of posyandu (0 - 7 times). Statistical tests showed that the age variable <30 years (p = 001. PR = 3,464), variable number of children under five (p = 0.041, PR = 3.509), under five age variables (p = 0.029, PR = 2.806), mother employment status variable ( p = 0.030, PR = 4.675), the mother's last education variable (p = 0.033, PR = 2,421), the mother's knowledge level variable (p = 0,000, PR = 9,100), and the mother's attitude variable (p = 0.005, PR = 3,077) . The knowledge level variable is the most dominant variable influencing the use of posyandu by toddlers aged 12-59 months. The researcher suggests that increasing the participation of all sectors in optimizing the implementation of posyandu.Conclusion : There is a relationship between maternal age, number of toddlers, toddler age, maternal employment status, last education, mother's level of knowledge and mother's attitude towards the use of posyandu
Small Interfering RNA (siRNA) of Mini circle DNA Transfection (McD) is Encapsulated by Gold Nanoparticles from Folate’s Receptors of Gold Conjugation as Curative Therapy for Non-Small’s Cell of Lung Cancer
Authors: Indrayani Agung Wiwiek , Sadvika I Gusti Ayu Sitti , Wiguna I Gede Wikania Wira , Remitha Ni Putu Sri Indrani , Sadeva I Gede Krisna Arim , Indrakusuma Anak Agung Bagus Putra , Wulandari Putri Ayu , Dewi Ni Wayan Sucindra 
Published: September 2021

Background: Lung cancer is one of the non-communicable diseases that have an increasing number of events that each year with a mortality rate of 18.4% and an incidence of 11.6%, occupies the top position based on GLOBOCAN data in 2018. One of management in the NSCLC is currently in the form of surgery and adjuvant therapy such as chemotherapy, radiotherapy and target therapy. However, there were weaknesses and limitations in care for its patients therefore development of curative therapy for NSCLC’s patients were needed. The aim of this review is to learn and investigate about the potential of siRNA that is transfected into McD and folate receptors alpha-conjugated gold nanoparticle encapsulation as a therapeutic opportunity that could be developed as a treatment in management of NSCLC.Method: The writing method used in this review article was the study method of literature. The used data comes from 45 of relevant literature sources and was arranged systematically in accordance with the topic of the problem discussed, along with the inclusion and exclusion criteria.Result: This treatment could increase gene transfection, siRNA biodistribution in organs, reduced KRAS, Bcl-2, and VEGF expression. Moreover, siRNA had entered phase III clinical trials and FOLR1 antibodies were in phase II of clinical trials.Conclusion: Utilization of siRNA specifically was designed for three genes such for KRAS, VEGF and Bcl-2 which were three genes that played a role in the pathogenesis of NSCLC, could be the right modality choice for treatment of NSCLC.
A randomized controlled clinical trial to evaluate safety and efficacy of a Unani formulation in the management of Kalaf (Melasma)
Authors: Qaiyyum Ifra Abdul , Nawab Mohammad , Kazmi Munawwar Husain 
Published: September 2021

Abstract

Objectives
Kalaf (Melasma) is an acquired facial hypermelanism. It has direct impact on patient’s quality of life and leads to development of various personality disorders. Lack of effective treatment and recurrences have drawn the attention of researcher to find alternative treatment. This study aimed to evaluate safety and efficacy of a topical Unani formulation in the management of melasma.

Methods
We conducted a prospective randomized controlled clinical study on the participants diagnosed with melasma. The participants (n=72) randomized into test (n=36) and control (n=36) groups. Sixty participants (n=30 in each group) completed the duration of therapy. The participants of the test group were treated with a classical Unani formulation and control group with hydroquinone 4%. The primary end point was change in mean MASI score and secondary end point was improvement in quality of life after eight weeks of treatment.

Results
The Unani formulation reduced 40.5% mean MASI score (17.31 ± 9.58 to 10.28 ± 5.92) in comparison to 32% reduction in mean MASI score (20.58 ± 9.49 to 13.92 ± 7.38) in the control group after eight weeks of treatment. When comparing with baseline the difference in MASI score was found statistically significant in both groups (p<0.05). On intergroup comparison, the change in MASI score between both groups was not statistically significant (p>0.05). In addition, MQOL and DQLI also improved significantly in both groups.

Conclusions
This study concluded that the Unani formulation and the control drug were equally effective and safer in the management of melasma.
Synthesis and structural characterization of a novel 2D supramolecular lead coordination polymer with phenanthroline derivate and adipic acid
Authors: Song Yu , Yan Yu , Zhang Hua , Wang Xiuyan 
Published: September 2021

Abstract
A new metal-organic coordination polymer, [Pb(L)(adip)0.5] (1) was synthesized under hydrothermal conditions by using 1-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)naphthalen-2-ol (HL) and adipic acid (H2adip). The complex 1 was characterized by diffraction and elemental analyses. In complex 1, the binuclear [Pb2L2] units were formed by the OH-deprotonation bridging neighboring Pb(II) atoms, and the adipate linked the binuclear [Pb2L2] units to form a symmetric one-dimensional chain. The 1D chain was further extended to the 2D supramolecular layer structure through π-π interactions between the L ligands.
Near-field optical imaging and spectroscopy of 2D-TMDs
Authors: Kim Youngbum , Kim Jeongyong 
Published: September 2021

Abstract
Two-dimensional transition metal dichalcogenides (2D-TMDs) are atomically thin semiconductors with a direct bandgap in monolayer thickness, providing ideal platforms for the development of exciton-based optoelectronic devices. Extensive studies on the spectral characteristics of exciton emission have been performed, but spatially resolved optical studies of 2D-TMDs are also critically important because of large variations in the spatial profiles of exciton emissions due to local defects and charge distributions that are intrinsically nonuniform. Because the spatial resolution of conventional optical microscopy and spectroscopy is fundamentally limited by diffraction, near-field optical imaging using apertured or metallic probes has been used to spectrally map the nanoscale profiles of exciton emissions and to study the effects of nanosize local defects and carrier distribution. While these unique approaches have been frequently used, revealing information on the exciton dynamics of 2D-TMDs that is not normally accessible by conventional far-field spectroscopy, a dedicated review of near-field imaging and spectroscopy studies on 2D-TMDs is not available. This review is intended to provide an overview of the current status of near-field optical research on 2D-TMDs and the future direction with regard to developing nanoscale optical imaging and spectroscopy to investigate the exciton characteristics of 2D-TMDs.
An overview of young chemists’ expectations towards the sustainable development of the chemical sector. Opinions that matter
Authors: Dobbelaar Emiel , Richter Janine 
Published: September 2021

Abstract
Young chemists play an important role in the transformation of the chemical sector in the next couple of years. They will have to do the heavy lifting and find the solutions needed for a sustainable tomorrow. Therefore, it is important to give them a voice in what their expectations are, how they believe they should be educated and prepared, and what opportunities they see for implementation levels in different areas to promote sustainable development. To shed light on these often under-represented opinions, young chemists across the globe were asked to express their views on the role and responsibilities of the chemical sector anonymously. The result is a snapshot of how young chemists perceive the future of chemistry and the immediate actions that need to be taken to get there. Throughout all answers, their hopes are expressed that the chemical sector will realize its great role and responsibility in leading and promoting sustainable development, thus limiting global warming, through cooperation with authorities, other sectors, and civil society. In this regard, young chemists do have numerous specific ideas about appropriate measures and are eager to take part in shaping a sustainable future.
Safety assessment of natural products in Malaysia: current practices, challenges, and new strategies
Authors: M. Pauzi Nur Azra , Cheema Manraj S. , Ismail Amin , Ghazali Ahmad Rohi , Abdullah Rozaini 
Published: September 2021

Abstract
The belief that natural products are inherently safe is a primary reason for consumers to choose traditional medicines and herbal supplements for health maintenance and disease prevention. Unfortunately, some natural products on the market have been found to contain toxic compounds, such as heavy metals and microbes, as well as banned ingredients such as aristolochic acids. It shows that the existing regulatory system is inadequate and highlights the importance of thorough safety evaluations. In Malaysia, the National Pharmaceutical Regulatory Agency is responsible for the regulatory control of medicinal products and cosmetics, including natural products. For registration purpose, the safety of natural products is primarily determined through the review of documents, including monographs, research articles and scientific reports. One of the main factors hampering safety evaluations of natural products is the lack of toxicological data from animal studies. However, international regulatory agencies such as the European Food Safety Authority and the United States Food and Drug Administration are beginning to accept data obtained using alternative strategies such as non-animal predictive toxicological tools. Our paper discusses the use of state-of-the-art techniques, including chemometrics, in silico modelling and omics technologies and their applications to the safety assessments of natural products.
An approach towards the synthesis of lithium and beryllium diphenylphosphinites
Authors: Berthold Chantsalmaa , Thomas-Hargreaves Lewis R. , Ivlev Sergei I. , Buchner Magnus R. 
Published: September 2021

Abstract
The diphenylphosphinites [(THF)Li(OPPh2)]4 and [(THF)2Be(OPPh2)2] have been synthesized via direct deprotonation of diphenylphosphine oxide with
n
BuLi and BePh2, respectively, as well as via salt metathesis. These compounds were characterized by multinuclear NMR spectroscopy, and the side-products of the reactions obtained under various reaction conditions have been identified. The beryllium derivative could not be isolated and decomposed into diphosphine oxide Ph2PP(O)Ph2. The solid-state structure of this final product together with that of [(THF)Li(OPPh2)]4 have been determined by single-crystal X-ray diffraction.
(−)-Brunneusine, a new phenolic compound with antibacterial properties in aqueous medium from the leaves of Agelanthus brunneus (Engl.) Tiegh (LORANTHACEAE)
Authors: Thomas Wieland Moifo Kuete , Pantaleon Ambassa , Luciane Marlyse Moungang , Bathelemy Ngameni , Thomas Storr E. , Bonaventure Ngadjui Tchaleu , Richard Stephenson G. 
Published: September 2021

Abstract

Agelanthus brunneus (Loranthaceae) is a hemiparasitic plant growing on Senna siamea (Fabaceae). The chemical investigation of its leaves and flowers led to the isolation of one new phenolic compound namely (−)-brunneusine (1), together with 13 known compounds. The crude leaves and flowers extracts (CLE and CFLE) with their ethyl acetate fractions (EAFL and EAFFL) and some isolated compounds (1–3; 8–9 and 11–14) have been tested on four bacterial species of sanitary importance isolated in an aquatic environment. All the samples except compound 3 showed antibacterial activity with MICs ranging from 0.43 to 8.88.103 µg/mL and MBCs from 0.43 to 3.55.103 µg/mL. Compounds 9 and 14 showed better activity on all bacterial species tested with MICs ranging from 0.43 to 27.77 µg/mL. Only CLE, EAFL and compounds 14, 2, 8 and 9 showed bactericidal effects on all bacterial species tested.
Long-term male fertility after treatment with radioactive iodine for differentiated thyroid carcinoma
Authors: Nies Marloes , Arts Eus G J M , van Velsen Evert F S , Burgerhof Johannes G M , Muller Kobold Anneke C , Corssmit Eleonora P M , Netea-Maier Romana T , Peeters Robin P , van der Horst-Schrivers Anouk N A , Cantineau Astrid E P , Links Thera P 
Published: September 2021

Context
Whilst radioactive iodine (RAI) is often administered in the treatment for differentiated thyroid carcinoma (DTC), long-term data on male fertility after RAI are scarce.

Objective
To evaluate long-term male fertility after RAI for DTC, and to compare semen quality before and after RAI.

Design, setting, and patients
Multicenter study including males with DTC ≥2 years after their final RAI treatment with a cumulative activity of ≥3.7 GBq.

Main outcome measure(s)
Semen analysis, hormonal evaluation, and a fertility-focused questionnaire. Cut-off scores for ‘low semen quality’ were based on reference values of the general population as defined by the World Health Organization (WHO).

Results
Fifty-one participants had a median age of 40.5 (interquartile range (IQR): 34.0–49.6) years upon evaluation and a median follow-up of 5.8 (IQR: 3.0–9.5) years after their last RAI administration. The median cumulative administered activity of RAI was 7.4 (range: 3.7–23.3) GBq. The proportion of males with a low semen volume, concentration, progressive motility, or total motile sperm count did not differ from the 10th percentile cut-off of a general population (P = 0.500, P = 0.131, P = 0.094, and P = 0.500, respectively). Cryopreserved semen was used by 1 participant of the 20 who had preserved semen.

Conclusions
Participants had a normal long-term semen quality. The proportion of participants with low semen quality parameters scoring below the 10th percentile did not differ from the general population. Cryopreservation of semen of males with DTC is not crucial for conceiving a child after RAI administration but may be considered in individual cases.
Applying Waveform Correlation to Reduce Seismic Analyst Workload Due to Repeating Mining Blasts
Authors: Sundermier Amy , Tibi Rigobert , Brogan Ronald A. , Young Christopher J. 
Published: September 2021

ABSTRACT
Agencies that monitor for underground nuclear tests are interested in techniques that automatically characterize mining blasts to reduce the human analyst effort required to produce high-quality event bulletins. Waveform correlation is effective in finding similar waveforms from repeating seismic events, including mining blasts. We report the results of an experiment to detect and identify mining blasts for two regions, Wyoming (U.S.A.) and Scandinavia, using waveform templates recorded by multiple International Monitoring System stations of the Preparatory Commission for the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO PrepCom) for up to 10 yr prior to the time of interest. We discuss approaches for template selection, threshold setting, and event detection that are specialized for characterizing mining blasts using a sparse, global network. We apply the approaches to one week of data for each of the two regions to evaluate the potential for establishing a set of standards for waveform correlation processing of mining blasts that can be generally applied to operational monitoring systems with a sparse network. We compare candidate events detected with our processing methods to the Reviewed Event Bulletin of the International Data Centre to assess potential reduction in analyst workload.
Body force equivalents for stress-drop seismic sources
Authors: Geller Robert J. 
Published: September 2021

abstract
The equivalent body forces for a stress-drop seismic source are found. When the isotropic stress drop and one of the three principal stress drops are zero, then the equivalent body forces are the same double couple without moment which would result from a shear dislocation. In general however, all six stress-drop components must be specified as independent functions of time.