bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational modelling and analysis of Pyrimidine analogues as EGFR inhibitor in search of anticancer agents
Authors: Reddy PurraBuchi , Madhusudana Reddy M.B , Reddy . Ramakrishna , Chhajed Santosh S. , Gupta Pramodkumar P. 
Published: April 2021

Introduction and Aim:Epidermal Growth Factor Receptor tyrosine kinase is a well-known and widely studied cancer therapeutic target protein. Based on the reported anticancer activity of pyrimidines, a series of 13 compounds are designed. In the present studythe EGFR kinase domain is targeted with the designed 13 compounds.
Materials and Methods:With missing residue in the kinase domain of EGFR crystallized structure, the domain is modelled using homology modelling, evaluated, energy-based optimization is carried out using OPLS in Gromacs. The default bindingsite was considered from the known EGFR kinase domain – Erlotinibcomplex crystallized structure. The molecular docking is carried out using AutodockVina, Insilico toxicity profiling and enrichment analysis of pathway is studied using Swiss-ADME and Enrich R.

Results:Compounds 7, 9, 10 and 12 revealed a binding energy of -8.8, -8.3, -8.3 and -8.4 Kcal/mol and makes two h-bonds with MET-769. All the 13 compounds are under the range of Lipnski drug likeness, with high GI-absorption rate. Considering the metabolic enzyme activity, the entire series of compounds are predicted to inhibit the metabolizing enzyme CYP1A2, CYP2D6 and CYP3A4. Compounds 2, 3, 7, 8 and 13 acts as a substrate to CYP2C19 and compound 1, 3,4, 5, 6, 7, 8, 9, 10, 11, 12 and 13 act as a substrate to CYP2C9.
Conclusion:The inhibition of metabolizing enzyme may affect the poor metabolizing and slowing down the excretion time of molecules from the body. The current in-silico molecular docking, in-silico PKPD study of compounds suggesting that they can be developed as putative lead compounds for developing new anti-cancer drugs.
Association of lumbar spine mobility and hamstring tightness in dental practitioners
Authors: Divyashri S. , Prathap Lavanya , Preetha S 
Published: April 2021

Introduction and Aim: The decrease in lumbar spine mobility and hamstring tightness can be caused due to the lack of regular exercise and awkward postures exposed at the workplace due to an individual's occupation. It can be expressed due to the awkward posture during dental practice as well and this can be controlled by doing regular exercises.The aim of the present study is to analyze the association of lumbar spine mobility and hamstring tightness in dental practitioners.

Materials and Methods: The study is conducted in a Private dental college and hospital for the dental practitioners who work for more than 4 hours in a day. The hamstring tightness is measured using the goniometer and lumbar spine flexibility is measured using an inch tape. The measurements are tabulated and analyzed statistically for the correlation of lumbar spine flexibility with hamstring tightness using the SPSS tool.

Results: The collected data are analyzed statistically using correlation coefficient and the findings concluded that they have a low positive correlation. The mean value of lumbar flexion range is 19.37 cm and mean value of the hamstring tightness is 27.8°, the correlation coefficient r is 0.473. Majority of female participants have increased hamstring tightness with a maximum range of 30° and around 11% of male participants have a restriction range of 25°. Similarly, around 8% of female participants have a lumbar flexion range of around 21cm, However, there is no significant difference between the gender in both the variables with p value equals 0.35 and 0.53 (p > 0.05) respectively.

Conclusion: From the obtained results it can be concluded that there is a low positive correlation between hamstring tightness and the lumbar flexion range. The findings suggest that the dental practitioners are prone to hamstring tightness which in turn can induce reduced lumbar spine mobility and impacts stress on the lumbar spine leading to low back pain.
Association of serum adenosine deaminase level with atherosclerotic index in type 2 diabetes mellitus patients
Authors: Rasheed Khan M , Vinod Babu S , KuzhandaiVelu V. 
Published: April 2021

Introduction and Aim:The atherosclerosis is the major cause of morbidity and mortality among diabetes population. Diabetes mellitus can accelerate atherosclerotic processes. Adenosine deaminase (ADA) plays a significant role in both glucose and lipid metabolism through adenosine. This study aimed to correlate the atherosclerotic index with adenosine deaminase levels in Type 2 diabetes mellitus patients. The aim of the study is to find the association between serum ADA levels with atherosclerotic index.

Materials and Methods: A cross sectional study conducted in 100 subjects (50 control and 50 T2DM patients). The following biochemical parameter were estimated:total cholesterol, triacylglycerol, HDL- C and ADA. VLDL, LDL and other atherosclerotic index were calculated using formulae. Statistical analysis such as Student’s‘t’ test and Pearson’s correlation were performed.

Results: We found significant increase (p value <0.001) in lipid profile, Non-HDL-C and lipid ratio when compared to T2DM with control group. The correlation of serum ADA with lipid profile and lipid ratio didnot show any correlation.

Conclusion: Serum ADA used as a biomarker for evaluation of glycemic status. ADA was insignificant, when correlated with dyslipidemia and atherosclerotic index.
A correlation between height, obesity and intelligence in South Indian medical students
Authors: Shifaya Fathima S , Francis Yuvaraj Maria , Francis Yuvaraj Maria , Senthil Kumar S. , K Balaji , Raghunath Gunapriya , Kumaresan M 
Published: April 2021

Introduction and Aim: Human intelligence is a cognitive process and was correlated with several anthropometric parameters. Height is one of the well-known factor that is suspected for a positive correlation with intelligence and their association is studied since many years. Similarly, obesity which has become a major health outcome of today is said to have a negative effect on intelligence. Prevalence of obesity and its co-morbidities are in a great rise in both developed and developing countries. Recent findings show that obesity could impair cognitive performance. This study focuses on the correlation of the parameters such as height and BMI(Body Mass Index) with intelligence for selected samples and underscores the significance of correlation. The objective of our study was to test whether a linear relationship exists between the IQ and the two parameters and their strength of correlation.

Materials and Methods: The present study was conducted at Saveetha Medical College and Hospital, Chennai. Sample consists of 50 students of age group 18-20 of phase I MBBS students and the present study was directed in the Department of Anatomy. Intelligence was measured by Standard Progressive Matrices (SPM), a non-verbal reasoning test. Height was measured in metres using stadiometer. Using height and weight values obtained from the sample, Body Mass Index (weight in kg/height in metre squares) was calculated. Mean and Standard Deviation of parameters were assessed and correlation value were calculated.

Results: The data were statistically analysed using correlation and regression. It showed positive correlation between height and intelligence (r=0.268) (p=0.05) and a negative correlation between obesity and intelligence (r= -0.324) (p=0.05).

Conclusion: Therefore, it concludes that height and intelligence were positively correlated, concomitantly obesity and intelligence were negatively correlated mainly due to increase in BMI has a deteriorating effect on intelligence.
Content or Context: Which is more important for publishing an article in high impact journals?
Authors: Pradhan Nitika 
Published: April 2021

Sir/ Madam,
To produce a high impact paper brings us to the question which matters more, a researcher’s oeuvre or the materials inside his/her article.Content is the total write-up and context is the theme or message behind the content. One can infer content from the context but not vice versa. In any article, context, includes the title as well as outcomes whereas content includes all, starting from introduction to conclusion part. Context provides a definite shape to the content and this idea or knowledge can be communicated by network of journals. During initial screening, the first thing an editor sees is the ‘title’ and then the content. If title is catchy, then only it attracts the reader/editor’s interest. So, here again the context comes first. However, when higher technologies were used to describe or justify the same context or idea, the paper is mostly accepted by high-tier journal basing upon the content but not context. Now people rarely think the motto or purpose of a journal. There is only a kind of competition between authors for their scientific credits /academic carrier or between editors for their journal publicity. Instead, we should remember that a journal, even high or low impact is only for a medium of communication where ideas from every corner of the world are reaching to every corner of the world. Lastly, there is a message “give priority to new idea/s because if idea is there then content will also come but without context or idea, content is meaningless”. Hence, the entire knowledge of ocean can only be filled by our drop by drop of collective contextual contributions.
EDUCAÇÃO SOCIAL COMO INSTRUMENTO DE HUMANIZAÇÃO PARA APRENDIZAGEM NO PROGRAMA DE CAPACITAÇÃO PROFISSIONAL
Authors: Farias Júnior Artur Alves , Andrade Ruth Sales Gama de 
Published: April 2021

Dentro da proposta pedagógica da Sala de Extensão PROPEX, ligada à Pró-Reitoria de Pesquisa e Extensão (PROPEX), no Campus Aracaju, do Instituto Federal de Sergipe (IFS), desde o início de 2016, a multidisciplinaridade é ferramenta fundamental para o enriquecimento da formação acadêmica e cidadã da comunidade interna e externa da instituição. Para a programação de 2017, o Programa de Capacitação Profissional (PCP) surge como leitura mais subjetiva e humanizada, baseando-se no tripé: segurança do trabalho, meio ambiente e saúde e, ainda, em conceitos de Educação Social para suporte da metodologia dos cursos oferecidos. Como opções, tem-se os cursos de NR 20 / Frentista de Postos Combustíveis e de Atendente de Farmácia. Deste modo, vê-se o PCP não só como um conjunto de cursos profissionalizantes, mas também como facilitador de aprendizagem ao propor conexões com temas cidadãos para o empoderamento do indivíduo e assim melhor prepará-lo para o mercado de trabalho. Nessa perspectiva, o presente trabalho propõe possibilitar a conexão do caráter reprodutivista de ensino de cursos de capacitação com o olhar humanizado, ao entendê-los como agentes transformadores na comunidade. Para nortear o estudo, além de conceitos literários, consideraram-se informações do Estatuto da Criança e do Adolescente (ECA), Organização das Nações Unidas para Educação, Ciência e Cultura (Unesco), Ministério do Desenvolvimento Social (MDS/BR) e aplicação de questionário com estudantes atendidos, de modo a demonstrar a evolução do programa.
Challenges for Life Cycle Assessment Of Palm Oil Production System
Authors: Stichnothe Heinz , Bessou Cécile 
Published: April 2021

Growing demand for palm oil is driven by increasing human population, income growth as well as biodiesel stimulation programs. Covering an area of over ten million ha in Indonesia, palm oil production is also one of the most important sources of crop residues while processing generates large amounts of wastewater. Cultivation and processing of this crop are considered as potentially large sources of emissions. Improving environmental impacts of the palm oil production can help to reduce existing emissions while increasing yield and generating surplus energy and farm income. However, area expansion for oil palm plantation is perceived as closely linked to illegal logging, deforestation and diminishing biodiversity. Apart from ensuring sustainable land use change, the use of residues is the most important criterion in ensuring sustainable palm oil. It is important to note that there are trade-offs (e.g. between maximizing bio energy production, reducing environmental impacts other than greenhouse gases (GHG), and sustaining soil fertility). Nitrogen (N) losses in palm oil production systems are a major environmental and economic issue. Unfortunately, there is little comprehensive knowledge on how to calculate N-budgets in oil palm plantation in order to optimize fertilization, taking into account N-leaching and N-gaseous emissions. Land use, soil-carbon, N-emissions and biodiversity are key aspects of life cycle assessment (LCA) of palm oil production systems and they pose a number of methodological questions.
Design of Integrated Data Management System for Sustainability Reporting and Program for Manufacturing Industries in Indonesia
Authors: Rahayu Priskila Christine , Amanda Daisy , Hanafi Jessica 
Published: April 2021

The manufacturing industry and its relationship with sustainable development simply cannot be separated. Especially, when the government started to show their attention by giving various obligations for the manufacturing industry to implement sustainable development principles, such as the obligation of the company to conduct a social and environmental responsibility by making sustainability report, the environmental impact assessment (AMDAL) report, to participate in various sustainability programs such as Corporate Performance Rating Program (PROPER) and Green Industry Award. There are so many indicators and data that need to be collected in order to fulfill these obligations. It certainly may charge the company in terms of time, yet the number of indicators and the data required were similar between one report to another. There is still no particular design to be able to resolve the issue. Therefore, the aim of this study is to design an integrated data management system for sustainability reporting needs and sustainability programs which has the end result of an application prototype of a system that can help companies, especially in the manufacturing industry to create reporting even more efficient. Data management is done by combining all four types of reporting and program which are Global Report Initiative sustainability report, the AMDAL report, Green Industry program, and PROPER. The prototype is made based on the results of data management using Microsoft Access to store data and to produce four types of summary reports. In the end of the study, it can be concluded that, overall, the system can be implemented and by the withdrawal of three respondents review, the system can improve the efficiency of the company in preparing sustainability reporting. In the evaluation phase, it is found a related method that can be used as the basis to do before making reporting in order to make them more easily 40.98%, that is Life Cycle Assessment.
Life Cycle Assessment Applications To The Dry Steam Geothermal Power Generation (Case Study: Star Energy Geothermal Wayang Windu, Ltd, Indonesia)
Authors: Annisa Rina , Rahardyan Benno 
Published: April 2021

Geothermal potential in Indonesia estimate can produced renewable energy 29 GW, and until 2016 it still used 5% or about 1643 MW in. From that result, about 227 MW produced by Wayang Windu geothermal power plant. The Input were raw material, energy and water. These input produced electricity as main product, by product, and also other output that related to environment i.e. emission, solid waste and waste water. All environmental impacts should be controlled to comply with environmental standard, and even go beyond compliance and perform continual improvement. This research will use Life Cycle Assessment method based on ISO 14040 and use cradle to gate concept with boundary from liquid steam production until electricity produced, and Megawatt Hours as the functional unit. Life Cycle Inventory has been done with direct input and output in the boundary and resulted that subsystem of Non Condensable Gas and condensate production have the largest environmental impact. LCI also show that every MWh electricity produced, it needed 6.87 Ton dry steam or 8.16 Ton liquid steam. Global Warming Potential (GWP) value is 0.155 Ton CO2eq./MWh, Acidification Potential (AP) 1.69 kg SO2eq./MWh, Eutrophication Potential (EP) 5.36 gPO4 eq./MWh and land use impacts 0.000024 PDF/m2. Life Cycle Impact Assessment resulted that AP contribute 78% of environmental impact and 98% resulted from H2S Non Condensable Gas. Comparison results with another dry steam geothermal power plant show that impact potential result of the company in good position and there’s a strong relation between gross production, GWP and AP value.Keywords: Life cycle assessment; Geothermal; Continual Improvement; Global Warming Potential; Acidification Potential
Ten Golden Rules for Applying Life Cycle Information
Authors: Fava Jim 
Published: April 2021

We have seen rivers burning, marine litter growing, climate change impacts increasing, limited resources to name a few. Often our resources are directed towards actions which we create unexpected impacts elsewhere, because we have not considered the full range of impacts along a product life cycle. Life cycle assessment has increasing become a tool of choice to understand the environmental and social trade-offs associated with product and packaging systems. What have we learned that can accelerate the generation and use of life cycle information to inform decision making? As we are approaching nearly 30 years of experiences, there is much still to do to develop the capacity and capabilities to generate and use life cycle information to ensure we are working on the right issue, at the right place in the value chain, and by the right groups. We see a future where products will be designed, manufactured, used and managed at the end of life in ways to create reduced environmental and social impacts than the previous generation. These innovative products will create business value, e.g., growing revenue, enhancing brand, reducing costs, and mitigating risk). All actors over a product’s life cycle have a role. New business models will surface. These outcomes are happening now, but not at the scale needed. Based upon nearly 30 years of experiences, we have identified Ten Golden Rules for applying life cycle information. These will be described with examples and guidance on how they can be applied within your own organization.
Pandangan Muhammad Asad tentang Shariah
Authors: Amir Ahmad nabil 
Published: April 2021

Abstrak:
This paper analyzed Muhammad Asad’s views on Shariah (Islamic law). This was investigated from his thoughtful and broad understanding of its principle and underlying purpose. The essential understanding of the principle of shariah was analytically discussed in his works such as This Law of Ours and Other Essays, The Principles of State and Government in Islam and in his magnum opus The Message of the Qur’an. The finding shows that Muhammad Asad’s discussion on shariah emphasized on its dynamic principle and relevance to contemporary practice and modern context of Islam. It set forth important framework towards reforming Islamic law by critically reconstructing and reprojecting its ideal in order to establish justice in implementing the law and in framing the ideal that underlie its purpose.
Fungsi Hukum dalam Pembangunan Ekonomi
Authors: Fachrodin Fachrodin 
Published: April 2021

Abstract: This journal entitle the Function Punish In Economics Development, what at one blow become the main problem studied. In the effort giving relevant input upon which basis for conduct the economic law development, it is important to know role punish to economic area. With this step will be able to be known the economic area demand at law area which can be made by a worthwhile input to support the economic growth. This article is inclusive of research punish the convergent normatif at substance punish the primary and sekunder. Problems studied by through legislation approach (statue approach) and approach analyse the concept punish the (analitical conseptual approach). internal issue Formula this study is: 1) How relation of among law economicly 2) How function punish in economic development?
Pursuant to inferential bibliography research that: 1) Between law and economic have the such correlation sliver between both. In microeconomic context, what its scope include; cover the business transaction from all economic perpetrator, stand in need of the law order which must have to be obeyed by the parties 2) Function And role punish very strategic in development in economic area. Extant law of regulation function to guide, to giving sanction guidance, and appliance for the merekayasa of social and economic life. Law function as medium to reach the target of economics development.
CONCEPT AND APPLICATION OF BASTI TREATMENT DURING PREGNANCY – A SCIENTIFIC APPROACH THROUGH AYURVEDA
Authors: Dr Deepal Patil  
Published: April 2021

Ayurveda is an indigenous system of medicine, emphasizes the Garbhavkranti (process of descent of various components in embryo) to prasava (process of labour) and sutika(puerperium) very well. In ayurveda Garbhini paricharya is planned for systemic supervision and care of a woman during nine months of pregnancy. In pregnancy only a little change in Ahara-Vihara leads to alter the doshas state. Vata dosha has a great influence on psychological built up which exerts considerable influence on maintaining normal pregnancy. Vitiated Vat dosha is the main reason for physical and psychological abnormalities in pregnant woman like PROM, IUGR etc. Basti therapy is the best curative treatment for vitiated Vata. Generally Panchakarma procedures are contraindicated in pregnancy but there are only few Basti treatments mentioned by Acharyas in Garbhini Paricharya which can give during pregnancy which are discussed in this article.
Keywords: Pregnancy, Vata dosha, Basti.
Study of degenerative changes in dhatukshayjanya janusandhigata vatavyadhi w. s. r. to knee osteoarthritis.
Authors: Gharge Archana , Teli Akshada 
Published: April 2021

Vatavyadhis get prime importance in Ayurvedic Classics, they are included in Ashtamahagad by Acharya Charak. Though it was prevalent in ancient times but due to modern life style, use of technologies, busy life schedule people are unable to follow Dincharya & Rutucharya, hence leading to many Vatavyadhis. The condition similar to Osteoarthritis has been described as â€˜Sandhigatavataâ€™ in Ayurveda, in which the vitiated Vata afflicts the joints . According to WHO osteoarthritis is the 2nd most common musculo-skeleton problem in the world population above 40 year of age is about 49% ,with a female to male ratio of 1:1. Female are found to be more affected by this disorder. In India it is expected as a fourth cause of disability by 2020. Hence the study of the lakshnas is very important while diagnosing a disease.
Dog Bite - An Ayurvedic Approach
Authors: Dhole Dnyaneshwar J. , Kale Rahul Hanumantrao 
Published: April 2021

Ayurveda is an ancient science that balanced state of these 3 doshas, Vata, Pitta, Kapha is a life & imbalanced state of doshases is called disease.
Ras, Rata, Mansa, Meda, Asthi, Majja, Shukra these are 7 dhatus. All 7 dhatuâ€™s Sar is known as Oaj. Oaj qualities is totally differ from poison. Oaj & poison qualities are opposite from each other.
Dog Bite is known as Aalarkvisha by Ayurvedic means. In the majority of cases Dog bite becomes Rabies or Hydrophobia due to delay in wound, poison management & wound unproper hygiene care.