bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐oxygen‐affinity hemoglobinopathy‐associated erythrocytosis: Clinical outcomes and impact of therapy in 41 cases
Authors: Gangat Naseema , Oliveira Jennifer L. , Hoyer James D. , Patnaik Mrinal M. , Pardanani Animesh , Tefferi Ayalew 
Published: October 2021

AbstractWe describe presenting features, treatment strategies, and follow‐up events involving 41 patients (median age 39 years, range 1–81; 54% males) with high oxygen affinity (HOA) hemoglobinopathy‐associated erythrocytosis, seen at our institution (1973–2020). Thirty‐four (83%) patients carried β‐chain (13 Malmo, 4 Olympia, 3 San Diego, 2 Wood) and 7 (17%) α‐chain (4 Dallas and one each Columbia‐Missouri, Jackson, and Wayne) variants. Median (range) hemoglobin (Hgb)/hematocrit (Hct), serum erythropoietin and p50 were 18 g/dL/52.9% (16–21.9/48–66), 10.4 mIU (4–36.3), and 20 mmHg (12–25), respectively. Family history was documented in 24 patients and history of thrombosis in two (5%). Treatment included phlebotomy in 23 and antiplatelet therapy in 21 patients. At a median follow‐up of 10 years, 23 (56%) patients reported one or more symptoms that were thought to be related to their increased Hct while thrombosis was documented in 10 (24%) patients. Neither Hgb/Hct level nor active phlebotomy showed a significant correlation with either thrombotic or nonthrombotic symptoms (p > .1 in all instances). Among 23 pregnancies recorded, 78% resulted in live births and no fetal loss was attributed to erythrocytosis. The current study does not implicate Hgb/Hct level as a major contributor of morbidity in HOA hemoglobinopathy‐associated erythrocytosis and suggests limited therapeutic value for phlebotomy.
Effect of the Particles Morphology on the Electrochemical Performance of Na3V2(PO4)2F3‐yOy
Authors: Fang Runhe , Olchowka Jacob , Pablos Chloé , Camacho Paula Sanz , Carlier Dany , Croguennec Laurence , Cassaignon Sophie 
Published: October 2021

AbstractAmong all the positive electrode materials explored for Na‐ion batteries, the family of Na3VIII2‐y(VIVO)y(PO4)2F3‐y (NVPFOy) has attracted extensive attention for its high operating voltage and structural stability. In order to promote better performance at high rates, it appears interesting to consider the correlation between NVPFOy’s composition, morphology (size and shape) and electrochemical properties. Here, solvothermal syntheses were considered in order to obtain a series of NVPFOy compounds showing different morphologies (such as nanospheres, flakes, cylindrical aggregates or desert‐roses) by playing on different synthesis parameters like water/ethanol ratio, stoichiometry of the precursors’ mixture, heating rate, and the presence or not of a surfactant. Four compounds presenting different morphology have been fully characterized by X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, infrared, NMR and XPS spectroscopies. Their electrochemical properties are studied using electrodes rich in active material in order to better observe the influence of the morphology on the energy storage performance and are compared to those of Na3V2(PO4)2F3 and Na3V2(PO4)2FO2 reference materials obtained by solid‐state synthesis and with shapeless morphology.
Phytochemical Variation within Aerial Parts of Ferula cupularis Populations, an Endangered Medicinal Plant from Iran
Authors: Narimani Rasoul , Tarakemeh Ameneh , Moghaddam Mohammad , Mahmoodi Sourestani Mohammad 
Published: October 2021

AbstractFerula cupularis (Boiss.) Spalik et S. R. Downie is an endangered endemic Iranian medicinal plant with occurrence restricted to Fars and Kohkilooyeh Boyerahmad provinces, Iran. F. cupularis is cited for strong antibacterial activity, usages in foodstuffs preservation, and has long been used by local peoples for ulcer treatment. In this research, the aerial parts of F. cupularis wild populations were collected from three natural habitats: Eqlid‐Kaftar (FC1), Kakan (FC2), and Sepidan‐Komohr (FC3), to assess phytochemical diversity and antioxidant activity. The quantity of essential oil (EO) ranged remarkably from 0.42 to 0.72 % v/w among the populations. Results obtained from the EO analysis by GC‐FID and GC/MS detected up to 56 compounds. α‐Pinene (21.65–31.53 %), sabinene (4.74–11.39 %), phellandrene (1.78–5.1 %), δ‐3‐carene (1.85–7.18 %), limonene (4.12–7.45 %), (Z)‐β‐ocimene (9.08–17.64 %), and elemicin (0.23–5.74 %) were the major compounds of EOs varied significantly among the populations. Moreover, total phenol content (250.54 to 387.45 mg gallic acid/100 g dry weight (DW)) and flavonoids (34.38 to 41.12 mg quercetin/100 g DW) of methanolic extracts varied substantially among the populations. Antioxidant activities of F. cupularis EOs and extracts were assessed by DPPH (2,2,1‐diphenyl‐1‐picrylhydrazyl) radical scavenging method. EOs exhibited EC50 values ranging from 8.88 to 9.67 μg mL−1 and the EC50 values for the extract ranged from 941.36 to 1335.96 μg mL−1 within the populations. Results demonstrated significantly different levels of antioxidant capacities among the studied populations. Monitoring the data, the population collected from Eqlid‐Kaftar (FC1) was selected as the most potent population concerning the highest EO content and antioxidant activity level. The obtained data provided new insights for an initial source of breeding plans and ultimately massive production for food and pharmaceutical industries.
Chemical Preintercalation of H2V3O8‐reduced Graphene Oxide Composites for Improved Na‐ and Li‐ion Battery Cathodes
Authors: Söllinger Daniela , Berger Thomas , Redhammer Günther J. , Schoiber Jürgen , Pokrant Simone 
Published: October 2021

AbstractDue to a growing demand for sustainable electrical energy storage alternatives to Li‐ion batteries (LIBs), Na‐ion batteries (SIBs) are of great interest because of the abundance of Na+. By modifying layered H2V3O8 by preintercalation and composite formation, improved electrochemical properties were obtained in LIBs. In analogy, a scalable soft chemistry synthesis is developed, to chemically presodiate H2V3O8 for the first time, in addition to a composite formation reaction with reduced graphene oxide (rGO). Crystal structure and morphology of all compounds are determined and their electrochemical properties as cathode are evaluated with respect to both Na+ and Li+ intercalation. The combination of preintercalation and composite formation leads to excellent initial capacities of 96 mAh ⋅ g−1 for SIBs and 371 mAh ⋅ g−1 for LIBs (58 % and 48 % higher than unmodified H2V3O8) at a practical current density of 100 mA ⋅ g−1, demonstrating that H2V3O8 is a promising cathode material for SIBs and LIBs.
Porous 3D Architecture of Carbon‐Encapsulated Fe3O4Nanospheres Anchored on Networks of Carbon Nanotubes as Anodes for Advanced Lithium‐Ion Batteries
Authors: Yuan Yapeng , Kong Zhen , Qiao Lei , Xu Zhengguan , Wang Zongyu , Teng Xinghe , Dong Yuhao , Liu Xuehua , Fu Aiping , Li Yanhui , Li Hongliang 
Published: October 2021

AbstractThe application of Fe3O4as anode material for lithium‐ion batteries is hindered by the capacity fade owing to its enormous volume expansion and the inherent low conductivity. Herein, carbon‐encapsulated Fe3O4nanospheres anchored on carbon nanotubes (Fe3O4/CNTs@C) have been successfully fabricated. The obtained Fe3O4/CNTs@C composites show that numerous Fe3O4nanospheres are held and connected by the CNT network, forming a composite of porous three‐dimensional structure. The unique structure improves the conductivity and structural stability of the Fe3O4/CNTs@C composite. The encapsulation with carbon enhances the contact between Fe3O4nanospheres and carbon nanotubes and shortens the ion‐transport path. As a result, the Fe3O4/CNTs@C delivers a high capacity of 612 mA h g−1at 1 A g−1, even after 200 cycles, and shows a superior rate performance of 523 mA h g−1at 5 A g−1. This work provides a preparation strategy that could be easily applied to other functional materials for energy storage and/or catalysis.
Herstellung und Charakterisierung von Polysulfon‐Membranen für die Gastrennung
Authors: Kluge Steven , Weiß Michael 
Published: October 2021

AbstractPolysulfon (PSU) ist ein geeignetes Material für die industrielle Gastrennung. In der vorliegenden Studie konnten mit speziellen Gießlösungen über den Trocken/Nass‐Phaseninversionsprozess PSU‐Flachmembranen mit einer porösen Stützstruktur und einer trennaktiven Deckschicht im Mikrometerbereich in einem Schritt hergestellt werden. Durch Variation der Zusammensetzung der Gießlösung und des Fällungsmediums konnte die Ausprägung der einzelnen PSU‐Schichten variiert werden. Zum Nachweis der Schichtstrukturen der PSU‐Flachmembranen wurden rasterelektronenmikroskopische Aufnahmen angefertigt. Die Gastrenneigenschaften wurden anhand von Permeabilitäten und idealen Trennfaktoren durch Gaspermeationsmessungen ermittelt.
Optimization of Gas Scrubbing in the Calcination of Struvite
Authors: Thumeyer Lucas , Bertau Martin , Fröhlich Peter 
Published: October 2021

AbstractDuring the calcination of magnesium ammonium phosphate hexahydrate (struvite) in the process of recycling to obtain phosphoric acid, ammonia is released in addition to water and carbon dioxide. With a gas scrubber, e.g., in the form of a bubble column reactor, ammonia can be recovered as a usable valuable material. With water as an inexpensive and effective absorbent, almost complete absorption (92 %) of the ammonia from the exhaust air can be achieved.
The prevalence and clinical associations of ultrasound measures of congestion in patients at risk of developing heart failure
Authors: Cuthbert Joseph J. , Pellicori Pierpaolo , Flockton Rachel , Kallvikbacka‐Bennett Anna , Khan Javed , Rigby Alan S. , Girerd Nicolas , Zannad Faiez , Cleland John G.F. , Clark Andrew L. 
Published: October 2021

AbstractAimsCongestion is a cardinal feature of untreated heart failure (HF) and might be detected by ultrasound (US) before overt clinical signs appear.Methods and resultsWe investigated the prevalence and clinical associations of subclinical congestion in 238 patients with at least one clinical risk factor for HF (diabetes, ischaemic heart disease, or hypertension) using three US variables: (i) inferior vena cava (IVC) diameter; (ii) jugular vein distensibility (JVD) ratio (the ratio of the jugular vein diameter during the Valsalva manoeuvre to that at rest); (iii) the number of B‐lines from a 28‐point lung US. US congestion was defined as IVC diameter > 2.0 cm, JVD ratio < 4.0 or B‐lines count > 14. The prevalence of subclinical congestion (defined as at least one positive US marker of congestion) was 30% (13% by IVC diameter, 9% by JVD ratio and 13% by B‐line quantification). Compared to patients with no congestion on US, those with at least one marker had larger left atria and higher plasma concentrations of natriuretic peptides. Patients with raised plasma N‐terminal pro‐B‐type natriuretic peptide/B‐type natriuretic peptide had a lower JVD ratio (7.69 vs. 8.80; P = 0.05) and more often had at least one lung B‐line (74% vs. 63%; P = 0.05). However, plasma natriuretic peptide concentrations were more closely related to left atrial volume than other US measures of congestion.ConclusionsSubclinical evidence of congestion by US is common in patients with clinical risk factors for HF. Whether these measurements provide additional value for predicting the development of HF and its prevention deserves consideration.
Power of moment‐based normality tests: Empirical analysis on Indian stock market index
Authors: Shaik Muneer , Gulhane Rutvik Digambar 
Published: October 2021

AbstractIn this paper, we study the power of moment‐based normality tests which include Jarque Bera (JB) test and D′Agostino and Pearson (DP) omnibus tests. Power comparison were obtained via Monte Carlo simulation of sample data generated from four alternative distributions like Uniform, Logistic, Student t and Gamma distribution. Our simulation results show that for Uniform distribution, DP test has better power compared to JB test. For Logistic, Student t and Gamma distributions, we find JB normality test to be powerful compared to DP test. We further apply the moment‐based normality tests empirically on the Indian stock market indices (NSE Nifty 50 and BSE Sensex) for different frequencies (daily, weekly, monthly and quarterly) during the period from 2010 to 2020. We find that daily returns of Indian stock indices are non‐normal whereas weekly, monthly and quarterly returns are normally distributed.
Comparative performance of annual wellness visits between pharmacists and physicians at primary care clinics
Authors: Moffatt Evelyn Kisakye , Wargo Ryan , Johnson Christa , Kawaguchi‐Suzuki Marina 
Published: October 2021

AbstractIntroductionAnnual wellness visits (AWVs) can help close care gaps, defined as differences between guideline‐recommended practice and actual care. The purpose of this study was to compare the performance of AWVs conducted by pharmacists and physicians toward care gap closure for the prevention and treatment of cardiovascular disease and osteoporosis.MethodsA retrospective chart review was conducted to evaluate interventions made during AWVs by pharmacists and physicians at primary care clinics. The variables of interest were (a) use of aspirin, statins, angiotensin‐converting enzyme inhibitors/angiotensin receptor II blockers, bisphosphonates, calcium/vitamin D, and proton pump inhibitors, and (b) need for dual energy x‐ray absorptiometry (DEXA) scans. The primary outcome was the rate of care gap closure examined between pharmacists' and physicians' panels.ResultsAmong 416 AWVs completed by pharmacists, 233 care gaps were identified, and 120 care gaps were closed. Similarly, among 169 AWVs completed by physicians, 103 care gaps were identified, and 27 gaps were closed. The rates of care gap closure were 0.29 ± 0.43 for physicians and 0.53 ± 0.48 for pharmacists (mean ± SD). The number of care gaps significantly improved between pre‐ and post‐AWVs for both groups (P < .01). The noninferiority test showed that the rates were noninferior for pharmacists compared with physicians (95% confidence interval: 0.12‐0.36). Overall, the most notable care gaps identified were (a) missing DEXA screenings, (b) inappropriate statin therapy, and (c) inappropriate calcium/vitamin D therapy. Reasons for not closing gaps were (a) declined drug therapy, (b) prior intolerance to medication, and (c) not completed DEXA scans. AWVs also corrected medication list inaccuracies and increased vaccination.ConclusionThis study showed that both pharmacists and physicians can utilize AWVs to close care gaps for the prevention and treatment of cardiovascular disease and osteoporosis, and the performance of pharmacists was noninferior to that of physicians.
Polyphenolic composition and antioxidant potential of underutilized Himalayan wild edible berries by high‐performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry
Authors: Sendri Nitisha , Bhandari Pamita 
Published: October 2021

AbstractThe Himalayan wild berries Myrica esculenta, Duchesnea indica, Prunus cerasoides, and Berberis lycium were studied for the first time for polyphenolic compositions using high‐performance liquid chromatography/electrospray ionization tandem mass spectrometry. The chemical analysis of extracts resulted in the identification of 69 polyphenols, including 11 anthocyanins, 28 phenolic acids, 19 flavanoids, 10 ellagitannins, and 1 dihydrochalcone. The caffeoylquinic acids, quercetin, kaempferol, and cyanidin are the common moieties in studied wild berries. In addition, seven phenolic compounds, that is, gallic acid, vanillic acid, caffeic acid, rutin, ferulic acid, quercetin, and myricetin were quantified. Among anthocyanins, cyanidin‐3‐O‐glucoside was the majorly quantified anthocyanin that ranged from 2.52 to 6.18% followed by delphinidin‐3‐O‐glucoside (0.6%–5.53%). The samples were assessed for total phenolics, total anthocyanin content, and antioxidant potential. The results showed that M. esculenta and B. lycium had the highest total phenolic and anthocyanin content and exhibited promising antioxidant activity with IC50 of 32.100 ± 0.42 and 48.44 ± 0.46 μg/mL, respectively. Principal component analysis was able to clearly differentiate between four underutilized Himalayan wild edible berries. The wide variability of polyphenolic constituents supports the consumption of these berries not only to achieve the nutrient requirements among local people but also as promising sources of antioxidants for the food industry.
A second‐order reduced multiscale method for nonlinear shell structures with orthogonal periodic configurations
Authors: Yang Zhiqiang , Liu Yizhi , Sun Yi , Ma Qiang 
Published: October 2021

AbstractThis article develops an efficient second‐order reduced multiscale (SORM) method to study the nonlinear shell structure with orthogonal periodic configurations. The heterogenous shell structure is periodically distributed in orthogonal curvilinear coordinate systems. At first, the nonlinear problems for the shell structure are introduced, and the detailed higher‐order nonlinear multiscale formulas based on the asymptotic homogenization approach are given including microscale unit cell functions, effective material parameter and the homogenized equation. Also, since it requires a large number of computation cost to solve the nonlinear multiscale problems by the traditional high‐order homogenization methods, the novel reduced order multiscale model is constructed. Further, according to the reduced‐order multiscale models and higher‐order nonlinear formulas, an effective SORM algorithm is provided for studying the nonlinear shell structures. The main characteristics of the proposed algorithm are that the novel reduced forms established to investigate the nonlinear shell structures and an efficient higher‐order homogenized solution evaluated by postprocessing that does not need higher‐order continuities of the homogenization solutions. Finally, according to some typical nonlinear examples including block structures, cylindrical shell and double‐curved shallow shell, the availabilities of the SORM algorithm are confirmed.
Enhancing the Reduction Kinetics of LiSF6 Batteries by Dispersed Cobalt Phthalocyanines on Porous Carbon
Authors: He Huajin , Liao Ying , Zuo Wenhua , Li Guochang , Gu Jiabao , Li Yixiao , Hu Zheng , Yang Yong 
Published: October 2021

AbstractReducing SF6 (as gas cathode) in Li batteries is a promising concept for the double benefit of mildly converting greenhouse SF6 and providing a high theoretical energy density of 3922 Wh kg−1. However, the reduction process is hampered by its sluggish kinetics. Here, cobalt phthalocyanine (CoPc) molecules immobilized on porous carbon matrix are, for the first time, introduced to the LiSF6 chemistry to deliver an enhanced energy density. It is revealed that the high redox potential of Co(II)Pc/[Co(I)Pc]− (≈2.85 V) facilitates the formation of Co(I)N4 sites to catalyze the SF6 electrochemical reduction. By using highly porous holey nitrogen‐doped carbon nanocages as carbon matrix, the LiSF6 cells deliver a high discharge voltage of 2.82 V at 50 mA gC+CoPc−1 and an unprecedented areal capacity of 25 mAh cm−2 at 0.1 mA cm−2, much superior to previous results. This work opens up new possibilities for high‐efficiency conversion of SF6 in lithium batteries.
In Situ Derived Hybrid Carbon Molecular Sieve Membranes with Tailored Ultramicroporosity for Efficient Gas Separation
Authors: Lee Tae Hoon , Moghadam Farhad , Jung Jae Gu , Kim Yu Jin , Roh Ji Soo , Yoo Seung Yeon , Lee Byung Kwan , Kim Jin Hee , Pinnau Ingo , Park Ho Bum 
Published: October 2021

AbstractFine control of ultramicroporosity (<7 Å) in carbon molecular sieve (CMS) membranes is highly desirable for challenging gas separation processes. Here, a versatile approach is proposed to fabricate hybrid CMS (HCMS) membranes with unique textural properties as well as tunable ultramicroporosity. The HCMS membranes are formed by pyrolysis of a polymer nanocomposite precursor containing metal‐organic frameworks (MOFs) as a carbonizable nanoporous filler. The MOF‐derived carbonaceous phase displays good compatibility with the polymer‐derived carbon matrix due to the homogeneity of the two carbon phases, substantially enhancing the mechanical robustness of the resultant HCMS membranes. Detailed structural analyses reveal that the in situ pyrolysis of embedded MOFs induces more densified and interconnected carbon structures in HCMS membranes compared to those in conventional CMS membranes, leading to bimodal and narrow pore size distributions in the ultramicroporous region. Eventually, the HCMS membranes exhibit far superior gas separation performances with a strong size‐sieving ability than the conventional polymers and CMS membranes, especially for closely sized gas pairs (Δd < 0.5 Å) including CO2/CH4 and C3H6/C3H8 separations. More importantly, the developed HCMS material is successfully prepared into a thin‐film composite (TFC) membrane (≈1 µm), demonstrating its practical feasibility for use in industrial mixed‐gas operation conditions.
Methods and Technologies for Mastering Uncertainty
Authors: Groche Peter , Abele Eberhard , Al-Baradoni Nassr , Bartsch Sabine , Bölling Christian , Brötz Nicolas , Gehb Christopher M. , Geßner Felix , Götz Benedict , Hartig Jakob , Hedrich Philipp , Hesse Daniel , Heßler Martina , Hoppe Florian , Joggerst Laura , Kersting Sebastian , Kloberdanz Hermann , Knoll Maximilian , Kohler Michael , Krech Martin , Lenz Jonathan , Leštáková Michaela , Logan Kevin T. , Martin Daniel , Melz Tobias , Müller Tim M. , Öztürk Tuğrul , Pelz Peter F. , Platz Roland , Rapp Andrea , Rexer Manuel , Schaeffner Maximilian , Schulte Fiona , Sinz Julian , Stegmeier Jörn , Weigold Matthias , Wendt Janine 
Published: October 2021

AbstractUncertainty affects all phases of the product life cycle of technical systems, from design and production to their usage, even beyond the phase boundaries. Its identification, analysis and representation are discussed in the previous chapter. Based on the gained knowledge, our specific approach on mastering uncertainty can be applied. These approaches follow common strategies that are described in the subsequent chapter, but require individual methods and technologies. In this chapter, first legal and technical aspects for mastering uncertainty are discussed. Then, techniques for product design of technical systems under uncertainty are presented. The propagation of uncertainty is analysed for particular examples of process chains. Finally, semi-active and active technical systems and their relation to uncertainty are discussed.
Outlook
Authors: Pelz Peter F. , Groche Peter , Pfetsch Marc E. , Schaeffner Maximilian 
Published: October 2021

AbstractBertolt Brecht once closed a text with the words “We are disappointed to see the curtain close and all questions are left unanswered” [1]. In this book, it has become clear that uncertainty is immanent in the product life cycle of technical systems in mechanical engineering from (B) production, (C) usage, (D) reuse to (E) sourcing. The latter is the starting phase of the following sequence B, C, D, E. Uncertainty has been relevant since the beginning of the industrialisation, cf. Theodor Fontane’s ballad ‘The Tay Bridge’ quoted in Chap. 10.1007/978-3-030-78354-9_1 and this will continue to be so. Hence, we will never see “the curtain close”, but a perpetual contribution of engineering science, applied mathematics, law and further branches of science to master uncertainty in mechanical engineering.