bluuebunny/crossref_metadata_2025_split huggingface dataset:
Movement in Aesthetic Experiences: What We Can Learn from Parkinson Disease
Authors: Humphries Stacey , Rick Jacqueline , Weintraub Daniel , Chatterjee Anjan 
Published: March 2021

Abstract
Visual art offers cognitive neuroscience an opportunity to study how subjective value is constructed from representations supported by multiple neural systems. A surprising finding in aesthetic judgment research is the functional activation of motor areas in response to static, abstract stimuli, like paintings, which has been hypothesized to reflect embodied simulations of artists' painting movements, or preparatory approach–avoidance responses to liked and disliked artworks. However, whether this motor involvement functionally contributes to aesthetic appreciation has not been addressed. Here, we examined the aesthetic experiences of patients with motor dysfunction. Forty-three people with Parkinson disease and 40 controls made motion and aesthetics judgments of high-motion Jackson Pollock paintings and low-motion Piet Mondrian paintings. People with Parkinson disease demonstrated stable and internally consistent preferences for abstract art, but their perception of movement in the paintings was significantly lower than controls in both conditions. The patients also demonstrated enhanced preferences for high-motion art and an altered relationship between motion and aesthetic appreciation. Our results do not accord well with a straightforward embodied simulation account of aesthetic experiences, because artworks that did not include visual traces of the artist's actions were still experienced as lower in motion by Parkinson patients. We suggest that the motor system may be involved in integrating low-level visual features to form abstract representations of movement rather than simulations of specific bodily actions. Overall, we find support for hypotheses linking motor responses and aesthetic appreciation and show that altered neural functioning changes the way art is perceived and valued.
Perceptual Grouping Reveals Distinct Roles for Sustained Slow Wave Activity and Alpha Oscillations in Working Memory
Authors: Diaz Gisella K. , Vogel Edward K. , Awh Edward 
Published: March 2021

Abstract
Multiple neural signals have been found to track the number of items stored in working memory (WM). These signals include oscillatory activity in the alpha band and slow-wave components in human EEG, both of which vary with storage loads and predict individual differences in WM capacity. However, recent evidence suggests that these two signals play distinct roles in spatial attention and item-based storage in WM. Here, we examine the hypothesis that sustained negative voltage deflections over parieto-occipital electrodes reflect the number of individuated items in WM, whereas oscillatory activity in the alpha frequency band (8–12 Hz) within the same electrodes tracks the attended positions in the visual display. We measured EEG activity while participants stored the orientation of visual elements that were either grouped by collinearity or not. This grouping manipulation altered the number of individuated items perceived while holding constant the number of locations occupied by visual stimuli. The negative slow wave tracked the number of items stored and was reduced in amplitude in the grouped condition. By contrast, oscillatory activity in the alpha frequency band tracked the number of positions occupied by the memoranda and was unaffected by perceptual grouping. Perceptual grouping, then, reduced the number of individuated representations stored in WM as reflected by the negative slow wave, whereas the location of each element was actively maintained as indicated by alpha power. These findings contribute to the emerging idea that distinct classes of EEG signals work in concert to successfully maintain on-line representations in WM.
Probing the Neural Systems Underlying Flexible Dimensional Attention
Authors: Buss Aaron T. , Magnotta Vincent , Hazeltine Eliot , Kinder Kaleb , Spencer John P. 
Published: March 2021

Abstract
Flexibly shifting attention between stimulus dimensions (e.g., shape and color) is a central component of regulating cognition for goal-based behavior. In the present report, we examine the functional roles of different cortical regions by manipulating two demands on task switching that have been confounded in previous studies—shifting attention between visual dimensions and resolving conflict between stimulus–response representations. Dimensional shifting was manipulated by having participants shift attention between dimensions (either shape or color; dimension shift) or keeping the task-relevant dimension the same (dimension same). Conflict between stimulus–response representations was manipulated by creating conflict between response-driven associations from the previous set of trials and the stimulus–response mappings on the current set of trials (e.g., making a leftward response to a red stimulus during the previous task, but being required to make a rightward response to a red stimulus in the current task; stimulus–response conflict), or eliminating conflict by altering the features of the dimension relevant to the sorting rule (stimulus–response no-conflict). These manipulations revealed activation along a network of frontal, temporal, parietal, and occipital cortices. Specifically, dimensional shifting selectively activated frontal and parietal regions. Stimulus–response conflict, on the other hand, produced decreased activation in temporal and occipital cortices. Occipital regions demonstrated a complex pattern of activation that was sensitive to both stimulus–response conflict and dimensional attention switching. These results provide novel information regarding the distinct role that frontal cortex plays in shifting dimensional attention and posterior cortices play in resolving conflict at the stimulus level.
Bordering Processes and Pony Wildness on Assateague Island
Authors: Britton Jennifer L. , Hunold Christian 
Published: March 2021

Abstract
This multispecies ethnography investigates how free-roaming ponies and humans participate in the production of “pony wildness” on Assateague Island, a barrier island located off the U.S. mid-Atlantic coast. The bordering practices of ponies intersect with the bordering practices of people to generate a relational conception of pony wildness that incorporates in people-pony relations a desire for intimacy with respect for autonomy, in a multifunctional landscape managed both as wilderness and as a beach tourism destination. This notion of pony wildness includes nonhuman charisma, fluidity, and managing human visitors. We conclude by discussing how the fluidity of pony wildness can help us think more imaginatively about other contexts in which communities of free-roaming nonhuman animals share space with human communities.
On Levels and Categories
Authors: Jameson Fredric R. 
Published: March 2021

Abstract
This article is a response by the author to the contributions to the Historical Materialism symposium on Allegory and Ideology. The reply is framed in terms of the different theoretical strategies through which the articulation of ‘Marx’ and ‘Freud’ has been carried out, namely the precarious syntheses of Freudo-Marxism, the homological method pioneered by Lucien Goldmann, and the theory of allegorical levels and transcoding explored in Allegory and Ideology. It critically engages with the openings and challenges posed by the various contributions to the symposium, focusing in particular on matters of periodisation, and concluding with a reflection on how a theory of allegorical levels can be complemented by a materialist understanding of the ‘category’.
Transposing Metaphors and Poetics from Text to World
Authors: Takacs Axel Marc Oaks 
Published: March 2021

Abstract
This article examines the use of Sufi lexicons (iṣṭilāḥāt) through the relatively unknown Mystical Commentary of the Love Lyrics of Ḥāƒiẓ by Abū al-Ḥasan Khatamī Lāhūrī. It resituates the iṣṭilāḥāt within the context of the philosophical-Sufi tradition, engaging theories of metaphor, imagination, poetry, and imaginaries from Ricœur, Castoriadis, Lakoff and Johnson, and Caputo. Rather than employing the iṣṭilāḥāt to produce a static correspondence between poetic terms and metaphysical realities, Lāhūrī’s theo-poetics transposes the metaphors and poetics of the poems into metaphors and poetics of this phenomenal world. This reading challenges previous criticisms of Sufi commentaries, particularly on the dīvān-i Ḥāfiẓ. The critique that the application of iṣṭilāḥāt disembodies or allegorizes the poetic images is challenged when they are interpreted within the philosophical-Sufi tradition. Contrary to literary criticisms of iṣṭilāḥāt, the poem is not merely a formal suitcase for mystical meaning; rather, poetics, the poem’s content, and theology create a nexus of interpretation for Lāhūrī.
Why Completeness and Coherence Matter for the European Court of Human Rights
Authors: Letwin Jeremy 
Published: March 2021

Abstract
The ECtHR has been much criticised for the lack of completeness and coherence of its judgments. Many of these critiques seem to presuppose an unarticulated theory about how complete and how coherent ECtHR judgments ought to be. My aim here is to articulate such a theory, in order to provide the foundations for a more principled critique of the jurisprudence of the ECtHR. I examine the nature of completeness and coherence in adjudication, and the reasons why the ECtHR should be particularly concerned with the completeness and coherence of its judgments. I identify instances in which ECtHR judgments have not been sufficiently complete and coherent, and I conclude by considering the implications this might have for making evaluations of the Court’s judgments in terms of legitimacy, justice, and desirability.
Limited Prosocial Emotions in a Clinical Population of Children and Adolescents: Proposal for Core and Ancillary Characteristics
Authors: de la Peña Francisco R. , Rosetti Marcos F. , Palacio Juan David , Palacios-Cruz Lino , Ulloa Rosa Elena 
Published: March 2021

Objective: Limited prosocial emotions (LPE) has been recently incorporated into international classifications as a specifier for conduct disorder in the DSM-5 and for all disruptive behavioural disorders in the ICD-11. The aims of the current work were to determine (a) the accuracy of each of the characteristics used to assess the LPE specifier and (b) whether the manner in which symptoms group together supports the idea of LPE having core characteristics. Method: Trained clinicians conducted interviews and determined LPE characteristics using responses from 74 parent/guardian and child/adolescent participants. Results: The distribution of LPE characteristics among those participants with LPE ( n = 13) was compared to those with only one LPE characteristic ( n = 11). The proposal of callous lack of empathy (CLE) and shallow deficient affect (SDA) as core characteristics was supported by strong associations with the presence of the LPE specifier, larger specificity, and sensitivity indices than those for unconcerned about performance and lack of remorse or guilt, as well as by a robust aggregation in a latent class analysis. Conclusions: CLE and SDA could be considered as core characteristics of LPE in children and adolescents.
Peripheral intravenous catheters in hospitalized patients: Practice, Dwell times, and factors impacting the dwell times: A single center retrospective study
Authors: Tripathi Sandeep , Gladfelter Taylor 
Published: March 2021

Background: Despite being the most common hospital procedure, limited information is available on the peripheral intravenous (PIV) catheter insertion practices. This study was designed to evaluate the contemporary PIV insertion practice (all age groups), and to identify the patient and device-related factors influencing the dwell times (<18 years). Methods: Single Center Retrospective study. Patients of all age groups admitted to the hospital for >4 midnights, from 01/2015 to 12/2019. Data extracted by automated EMR audits. Variables included patient demographics, number of PIVs inserted, PIV size, location, dwell time, and length of stay. Standard comparative analysis, including multivariable linear regression for dwell time performed for patients <18 years. Results: A total of 44,198 (39,341 (89%) adults and 4857 (11%) children) PIVs on unique patients met study criteria, with mean duration of 2.8 ± 2.4 days in children and 2.6 ± 1.3 days in adults ( p < 0.001). Pediatric PIV had more dwell time variation, with a higher proportion lasting <1-day and also >2 SD of the age-specific mean, compared to adults. Adults had significantly higher number of PIVs placed/week compared to children. The failure rate for PIV was 56% in children and 76% in adults ( p < 0.001). 1 out of 5 adults required >5 PIV/admission. Forty-five percent of children requiring only one PIV versus 21.8% of seniors. Discharge department, body part, and PIV size were independently associated with the dwell duration in children. No PIV size, however, had an independent increase in dwell duration over the reference of the 24 Ga cannula in children. PIVs placed in ante cubital vein and upper arm had dwell duration 26% and 20% longer than PIVs placed in the hand. Conclusions: The failure rate of PIV is high, and patients are subjected to multiple insertions during hospitalization. Hospital unit, body part, and PIV size are associated with the dwell duration in children.
Instagram and Spine Fusion: An Analysis of Social Media and Its Relationship to Patient Perception of Surgery
Authors: Rizkalla James M. , Holderread Brendan , Hotchkiss William , Clavenna Andrew , Dossett Andrew , Ogola Gerald , Syed Ishaq 
Published: March 2021

Study Design: Cross sectional study. Objectives: To analyze posts shared on Instagram referencing spinal fusion for tone, gender, activities of daily living (ADLs), rehabilitation, incision, pain, neurological injury, and content of post. Methods: Public instragram posts, which were isolated and evaluated using the hashtags “#spinefusion” and “#spinalfusion.” All posts were analyzed by the authors for the variables previously listed. In total, 264 posts were included for investigation and analysis of patient perception of spine fusion through social media. Results: Of all included posts, approximately 86% of posts had a positive tone. There was statistical significance between positive tone and activities of daily living (ADLs) ( P = 0.047), as well as negative tone and persistent pain ( P = 0.008). Adequate return to activities of daily living is perceived by patients as a positive outcome after surgery: odds ratio (OR) (95% CI) of 2.11 (1.01-4.39). Persistent post operative pain results negatively on perceived outcomes after surgery OR = 0.38 (0.18-0.78). Conclusions: Reported outcomes after spine fusion has not been evaluated through social media avenues. This analysis of patients sharing their experience on social media after spinal fusion demonstrates that returning to activities of daily living is of the utmost importance to patients. Additionally, post-operative pain is a strong metric utilized by patients with their satisfaction after surgery.
CSR and corporate taxes: Substitutes or complements?
Authors: Timbate Lukas 
Published: March 2021

There is a debate in academia and the business world on whether tax payments should be considered part of firms’ social responsibility. Existing literature provides conflicting evidence on the relationship between corporate tax payments and corporate social responsibility (CSR). Borrowing a concept from a behavioral theory of the firm (BTOF), this study attempts to present a more refined model on the relationship between the two. The results in this study reveal that as firms’ performance rises further above their aspiration level, they are less likely to show better CSR performances and are also less likely to avoid taxes. Firms performing just above their aspiration level show higher CSR performances and firms performing nearby (both below and above) their aspiration level avoid more taxes. In conclusion, firms’ CSR and tax payment decisions are related to the desire to meet or beat an aspiration level or sustain competitive advantage than being ethical or unethical. JEL CLASSIFICATION M14; H26
Three-dimensional textural investigation of sulfide mineralisation from the Loolekop carbonatite–phoscorite polyphase intrusion in the Phalaborwa Igneous Complex (South Africa), with implications for ore-forming processes
Authors: Le Bras Loic Y. , Bolhar Robert , Bam Lunga , Guy Bradley M. , Bybee Grant M. , Nex Paul A.M. 
Published: March 2021

AbstractCopper-sulfides within carbonatites and phoscorites of the Phalaborwa Igneous Complex, South Africa, have been investigated since the middle of the 20th Century. However, aspects of ore formation have remained unclear. This study examines the mechanisms involved in Cu-sulfide mineralisation by micro-focus X-ray computed tomography as applied to sulfide-rich drill core samples. Several texturally distinct assemblages of magmatic sulfides can be identified, including: (1) <500 μm rounded bornite and chalcopyrite grains disseminated within the gangue; (2) elongated mm-scale assemblages of chalcopyrite and bornite; and (3) mm-to-cm thick chalcopyrite cumulates. Chalcopyrite veins were also observed, as well as late-stage valleriite, documenting late-stage fluid circulation within the pipe, and alteration of magmatic and hydrothermal sulfides along fractures within the gangue, respectively. The results of micro-focus X-ray computed tomography indicate that magmatic sulfides are sub-vertically aligned. Spatial variability of the sulfide assemblages suggests that textural changes within sulfide layers reflect fluctuating magma flow rate during emplacement of carbonatite–phoscorite magmas, through coalescence or breakup of sulfide liquid droplets during ascent. Modal sulfide abundances, especially for disseminated assemblages, differ from one carbonatite–phoscorite layer to another, suggesting a strong control of the mechanical sorting in the formation of Cu-sulfide textures within the Loolekop carbonatite. The alternation of carbonatite and phoscorite within the intrusion suggest that the Loolekop Pipe was emplaced through a series of successive magma pulses, which differentiated into carbonatite and phoscorite by melt immiscibility/progressive fractional crystallisation and pressure drop. Three-dimensional textural analysis represents an effective tool for the characterisation of magma flow and is useful for the understanding of magmatic processes controlling sulfide liquid-bearing phoscorite–carbonatite magmas.
Acalabrutinib in treatment-naive chronic lymphocytic leukemia
Authors: Byrd John C. , Woyach Jennifer A. , Furman Richard R. , Martin Peter , O’Brien Susan , Brown Jennifer R. , Stephens Deborah M. , Barrientos Jacqueline C. , Devereux Stephen , Hillmen Peter , Pagel John M. , Hamdy Ahmed , Izumi Raquel , Patel Priti , Wang Min Hui , Jain Nitin , Wierda William G. 
Published: March 2021

Abstract
Acalabrutinib has demonstrated significant efficacy and safety in relapsed chronic lymphocytic leukemia (CLL). Efficacy and safety of acalabrutinib monotherapy were evaluated in a treatment-naive CLL cohort of a single-arm phase 1/2 trial (ACE-CL-001). Adults were eligible for enrollment if chemotherapy was declined or deemed inappropriate due to comorbidities (N = 99). Patients had a median age of 64 years and 47% had Rai stage III/IV disease. Acalabrutinib was administered orally 200 mg once daily, or 100 mg twice daily until progression or intolerance. A total of 99 patients were treated; 57 (62%) had unmutated immunoglobulin heavy-chain variable gene, and 12 (18%) had TP53 aberrations. After median follow-up of 53 months, 85 patients remain on treatment; 14 discontinued treatment, mostly because of adverse events (AEs) (n = 6) or disease progression (n = 3). Overall response rate was 97% (90% partial response; 7% complete response), with similar outcomes among all prognostic subgroups. Because of improved trough BTK occupancy with twice-daily dosing, all patients were transitioned to 100 mg twice daily. Median duration of response (DOR) was not reached; 48-month DOR rate was 97% (95% confidence interval, 90-99). Serious AEs were reported in 38 patients (38%). AEs required discontinuation in 6 patients (6%) because of second primary cancers (n = 4) and infection (n = 2). Grade ≥3 events of special interest included infection (15%), hypertension (11%), bleeding events (3%), and atrial fibrillation (2%). Durable efficacy and long-term safety of acalabrutinib in this trial support its use in clinical management of symptomatic, untreated patients with CLL.
Microenvironment immune reconstitution patterns correlate with outcomes after autologous transplant in multiple myeloma
Authors: Parmar Harsh , Gertz Morie , Anderson Emilie Ingrid , Kumar Shaji , Kourelis Taxiarchis V. 
Published: March 2021

Abstract
The immediate postautologous stem cell transplant (ASCT) period in multiple myeloma represents a unique opportunity for long-term disease control because many patients have eradicated most of their disease but also a challenge because it is characterized by the increase of immune subsets detrimental to tumor immunosurveillance. The impact of the tumor immune microenvironment (iTME) in post-ASCT outcomes is not known. In this study, we included 58 patients undergoing upfront ASCT and evaluated their cellular and humoral iTME with cytometry by time of flight (CyTOF) and luminex, respectively, at day +60 to 100 post-ASCT. We identified 2 cellular iTME patterns. Group 1 was enriched in T-cell subsets at the opposite ends of the spectrum of T-cell differentiation compared with the rest of the patients, that is, cells already terminally differentiated (immune senescent or exhausted) and naive T cells. This group had worse hematologic responses post-ASCT, inferior survival, and shorter time to hematologic progression independent of established risk factors. No differences in the humoral iTME were noted between the 2 groups. In addition, no differences in the cellular/humoral iTME were noted according to high-risk fluorescence in situ hybridization status, early or late relapse. Finally, males had higher levels of natural killer cells negative for CD16, a key receptor mediating antibody-dependent cell cytotoxicity, a major mechanism of antitumor efficacy by therapeutic antibodies such as elotuzumab. Our findings suggest that T-cell iTME dysfunction post-ASCT, some of which could be reversible (exhaustion), correlates with worse outcomes. These results could be used to guide rational selection of post-ASCT maintenance/consolidation approaches in these patients.
Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation
Authors: Liggett L. Alexander , Galbraith Matthew D. , Smith Keith P. , Sullivan Kelly D. , Granrath Ross E. , Enriquez-Estrada Belinda , Kinning Kohl T. , Shaw Jessica R. , Rachubinski Angela L. , Espinosa Joaquin M. , DeGregori James 
Published: March 2021

Key Points
Children with Down syndrome develop early signs of clonal evolution that resemble traditional clonal hematopoiesis. Children with trisomy 21 who exhibit clonal hematopoiesis display cytokine and gene expression profiles indicative of disrupted immunity.