bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis
Authors: Göhler Daniel , Geldner Antje , Gritzki Ralf , Lohse Franz , Große Stephan , Sobilo Julien , Felsmann Clemens , Buggisch Jonathan R. , Le Pape Alain , Rudolph Andreas , Stintz Michael , Giger-Pabst Urs 
Published: November 2021

AbstractPressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a promising approach with a high optimization potential for the treatment of peritoneal carcinomatosis. To study the efficacy of PIPAC and drugs, first rodent cancer models were developed. But inefficient drug aerosol supply and knowledge gaps concerning spatial drug distribution can limit the results based on such models. To study drug aerosol supply/deposition, computed tomography scans of a rat capnoperitoneum were used to deduce a virtual and a physical phantom of the rat capnoperitoneum (RCP). RCP qualification was performed for a specific PIPAC method, where the capnoperitoneum is continuously purged by the drug aerosol. In this context, also in-silico analyses by computational fluid dynamic modelling were conducted on the virtual RCP. The physical RCP was used for ex-vivo granulometric analyses concerning drug deposition. Results of RCP qualification show that aerosol deposition in a continuous purged rat capnoperitoneum depends strongly on the position of the inlet and outlet port. Moreover, it could be shown that the droplet size and charge condition of the drug aerosol define the deposition efficiency. In summary, the developed virtual and physical RCP enables detailed in-silico and ex-vivo analyses on drug supply/deposition in rodents.
Trends and disparities in osteoarthritis prevalence among US adults, 2005–2018
Authors: Xu Yingke , Wu Qing 
Published: November 2021

AbstractStudies reporting trends and disparities of osteoarthritis (OA) in the United States are limited. We aimed to examine trends and disparities of OA prevalence among US adults, from 2005 to 2018. Continuous National Health and Nutrition Examination Survey (NHANES) data from 2005–2006 to 2017–2018 were analyzed. Age-adjusted and self-reported OA prevalence, stratified by race/ethnicity and socioeconomic status (SES), was calculated separately for men and women. The linear trend and the association between the survey cycles and OA prevalence were assessed. Age-adjusted and self-reported OA prevalence linearly increased in the seven survey cycles (both Plinear trend ≤ 0.0002) in men and women. Non-Hispanic Caucasians (both Plinear trend ≤ 0.0001) in both genders and Non-Hispanic African Americans women (Plinear trend ≤ 0.0001) had significantly increasing linear trends in OA prevalence. In addition, people with lower SES had a lower age-adjusted prevalence of self-reported OA when compared to those with higher SES. The increasing linear trends still existed among both men and women after adjusting for multiple confounders (both Plinear trend ≤ 0.002). There were significant rising trends and disparities in self-reported OA prevalence among US men and women between 2005 and 2018.
The hypertriglyceridemic-waist phenotype as a valuable and integrative mirror of metabolic syndrome traits
Authors: de Cuevillas Begoña , Alvarez-Alvarez Ismael , Riezu-Boj Jose I. , Navas-Carretero Santiago , Martinez J. Alfredo 
Published: November 2021

AbstractRates of non-communicable diseases (NCDs), such as obesity, diabetes, cardiovascular events and cancer, continue to rise worldwide, which require objective instruments for preventive and management actions. Diverse anthropometric and biochemical markers have been used to qualitatively evaluate degrees of disease, metabolic traits and evolution of nutritional status. The aim of this study was to integrate and assess the interactions between an anthropometric measurement, such as waist circumference (WC), and biochemical data, such as the triglyceride glucose index (TyG), in order to individually characterize metabolic syndrome (MetS) features considering the hypertriglyceridemic waist phenotype as a marker. An ancillary cross-sectional study was conducted using anthropometric measurements, such as weight, height, waist and hip circumferences, as well as fasting biochemical data of 314 participants. Different indices based on WC (WC, WC*TG and WC*TyG) were estimated to compute MetS components and accompanying comorbidities. ROC curves were fitted to define the strength of the analyses and the validity of the relationships. Associations were confirmed between anthropometric, biochemical and combined indices with some chronic disease manifestations, including hyperglycemia, hypertension and dyslipidemia. Both WC*TG and WC*TyG indices showed similar performance in diagnosing MetS (area under the ROC curve = 0.81). Interestingly, when participants were categorized according to a reference value of the WC*TyG index (842.7 cm*mg/dl), our results evidenced that subjects classified over this limit presented statistically higher prevalence of MetS and accompanying individual components with clinical relevance for interventions. These results revealed that WC*TyG mirrors the hypertriglyceridemic phenotype, which suggests may serve as a good indicator to define the metabolic syndrome phenotype and a suitable, sensitive, and simple proxy to complement others. A reference point was proposed with a good clinical performance and maximized sensitivity and specificity values.
Human endothelial cells and fibroblasts express and produce the coagulation proteins necessary for thrombin generation
Authors: Cohen Clay T. , Turner Nancy A. , Moake Joel L. 
Published: November 2021

AbstractIn a previous study, we reported that human endothelial cells (ECs) express and produce their own coagulation factors (F) that can activate cell surface FX without the additions of external proteins or phospholipids. We now describe experiments that detail the expression and production in ECs and fibroblasts of the clotting proteins necessary for formation of active prothrombinase (FV–FX) complexes to produce thrombin on EC and fibroblast surfaces. EC and fibroblast thrombin generation was identified by measuring: thrombin activity; thrombin–antithrombin complexes; and the prothrombin fragment 1.2 (PF1.2), which is produced by the prothrombinase cleavage of prothrombin (FII) to thrombin. In ECs, the prothrombinase complex uses surface-attached FV and γ-carboxyl-glutamate residues of FX and FII to attach to EC surfaces. FV is also on fibroblast surfaces; however, lower fibroblast expression of the gene for γ-glutamyl carboxylase (GGCX) results in production of vitamin K-dependent coagulation proteins (FII and FX) with reduced surface binding. This is evident by the minimal surface binding of PF1.2, following FII activation, of fibroblasts compared to ECs. We conclude that human ECs and fibroblasts both generate thrombin without exogenous addition of coagulation proteins or phospholipids. The two cell types assemble distinct forms of prothrombinase to generate thrombin.
Effects of polyimide curing on image sticking behaviors of flexible displays
Authors: Kim Hyojung , Park Jongwoo , Bak Sora , Park Jungmin , Byun Changwoo , Oh Changyong , Kim Bo Sung , Han Chanhee , Yoo Jongmin , Kim Dongbhin , Song Jangkun , Choi Pyungho , Choi Byoungdeog 
Published: November 2021

AbstractFlexible displays on a polyimide (PI) substrate are widely regarded as a promising next-generation display technology due to their versatility in various applications. Among other bendable materials used as display panel substrates, PI is especially suitable for flexible displays for its high glass transition temperature and low coefficient of thermal expansion. PI cured under various temperatures (260 °C, 360 °C, and 460 °C) was implemented in metal–insulator–metal (MIM) capacitors, amorphous indium gallium zinc oxide (a-IGZO) thin-film transistors (TFT), and actual display panels to analyze device stability and panel product characteristics. Through electrical analysis of the MIM capacitor, it was confirmed that the charging effect in the PI substrates intensified as the PI curing temperature increased. The threshold voltage shift (ΔVth) of the samples was found to increase with rising curing temperature under negative bias temperature stress (NBTS) due to the charging effect. Our analyses also show that increasing ΔVth exacerbates the image sticking phenomenon observed in display panels. These findings ultimately present a direct correlation between the curing temperature of polyimide substrates and the panel image sticking phenomenon, which could provide an insight into the improvement of future PI-substrate-based displays.
Genomic analysis of a rare recurrent Listeria monocytogenes prosthetic joint infection indicates a protected niche within biofilm on prosthetic materials
Authors: Hutchins Chloe , Sayavedra Lizbeth , Diaz Maria , Gupta Puja , Tissingh Elizabeth , Elumogo Chiamaka , Nolan John , Charles Ian , Elumogo Ngozi , Narbad Arjan 
Published: November 2021

AbstractListeria monocytogenesis a rare cause of prosthetic joint infections (PJI). In this study, we describe a case of recurrentL. monocytogenesinfections, 39 months apart, following debridement and retention of a prosthetic hip. Despite numerous studies reporting persistentL. monocytogenesin human infections, the genomic and phenotypic changes that clinically relevant strains undergo in the host are poorly understood. Improved knowledge of how PJI occurs is needed to improve the management of prosthetic infections. We used a combination of long- and short-read sequencing to identify any potential genomic differences between twoL. monocytogenesisolates that occurred over 39-month incubation in the host. The isolates, QI0054 and QI0055, showed three single nucleotide polymorphisms and three insertions or deletions, suggesting that the recurrent infection was caused by the same strain. To identify potential differences in the capacity for persistence of these isolates, their biofilm-forming ability and potential to colonize prosthesis-relevant materials was investigated both in microtitre plates and on prosthetic material titanium, stainless steel 316 and ultra-high molecular weight polyethylene. Whilst theL. monocytogenesisolate from the most recent infection (QI0055) was able to form higher biofilm in microtitre plates, this did not lead to an increase in biomass on prosthetic joint materials compared to the initial isolate (QI0054). Both clinical isolates were able to form significantly more biofilm on the two metal prosthetic materials than on the ultra-high molecular weight polyethylene, in contrast to reference strain Scott A. Transcriptomics revealed 41 genes overexpressed in biofilm state and 643 in planktonic state. Moreover, genes with mutations were actively expressed in both isolates. We conclude the isolates are derived from the same strain and hypothesize thatL. monocytogenesformed biofilm on the prosthetic joint materials, with minimal exposure to stresses, which permitted their survival and growth.
Polarization-dependent optical responses in natural 2D layered mineral teallite
Authors: Tripathi Ravi P. N. , Yang Xiaodong , Gao Jie 
Published: November 2021

AbstractMulti-element layered materials enable the use of stoichiometric variation to engineer their optical responses at subwavelength scale. In this regard, naturally occurring van der Waals minerals allow us to harness a wide range of chemical compositions, crystal structures and lattice symmetries for layered materials under atomically thin limit. Recently, one type of naturally occurring sulfide mineral, ternary teallite has attained significant interest in the context of thermoelectric, optoelectronic, and photovoltaic applications, but understanding of light-matter interactions in such ternary teallite crystals is scarcely available. Herein, polarization-dependent linear and nonlinear optical responses in mechanically exfoliated teallite crystals are investigated including anisotropic Raman modes, wavelength-dependent linear dichroism, optical band gap evolution, and anisotropic third-harmonic generation (THG). Furthermore, the third-order nonlinear susceptibility of teallite crystal is estimated using the thickness-dependent THG emission process. We anticipate that our findings will open the avenue to a better understanding of the tailored light-matter interactions in complex multi-element layered materials and their implications in optical sensors, frequency modulators, integrated photonic circuits, and other nonlinear signal processing applications.
Bimetallic Ag–Cu-trimesate metal–organic framework for hydrogen sulfide removal
Authors: Gupta Nishesh Kumar , Bae Jiyeol , Kim Kwang Soo 
Published: November 2021

Bimetallic Ag-Cu-trimesate metal-organic framework was fabricated for H2S mineralization. The MOF was partially regenerated using H2O2 solution for five cycles.
Predicting intrinsic antiferromagnetic and ferroelastic MnF4 monolayer with controllable magnetization
Authors: Xu Shaowen , Jia Fanhao , Cheng Xuli , Ren Wei 
Published: November 2021

MnF4 monolayer is predicted to an antiferromagnetic and ferroelastic material with magnetic anisotropy and magneto-elastic coupling, which can be effectively controlled by biaxial strain or carrier doping.
Quantised control for local Mittag–Leffler stabilisation of fractional‐order neural networks with input saturation: A refined sector condition
Authors: Fan Yingjie , Huang Xia , Wang Zhen , Li Yuxia 
Published: November 2021

AbstractThis brief focuses on the local Mittag–Leffler stabilisation of fractional‐order neural networks via quantised control with input saturation. First, a refined sector condition is put forward, which can deal with the problem of the simultaneous existence of quantiser effect and actuator constraint. With the aid of refined sector condition, theoretical analysis on the local Mittag–Leffler stabilisation of the resulting closed‐loop systems is carried out by using some inequality techniques on Mittag–Leffler function and fractional‐order Lyapunov theory. In addition, two convex optimisation schemes are respectively developed to minimise the cost of actuators and to enlarge the admissible initial region. Finally, a three‐neurons fractional‐order neural networks is applied to illustrate the effectiveness of the derived results.
Comparative analysis of leakage current suppression capability of forward‐clamped and reverse‐clamped H10 three‐phase inverters
Authors: Ma Haixiao , Shao Pengcheng , Lan Zhaixing 
Published: November 2021

AbstractNon‐isolated inverters have the disadvantage of large leakage current, which will damage the equipment and personal safety. In order to solve this problem, this paper proposes two H10 three‐phase inverter topologies named forward‐clamped and reverse‐clamped H10 inverters. Each of the topologies is composed of two DC bus switches, a clamping circuit and a traditional three‐phase inverter, but the clamping method of these two topologies is different. A general control strategy combining carrier modulation and logic operation for these two topologies are proposed. The control strategy allows the common‐mode voltage of these two topologies to vary between one third and two thirds of the DC bus voltage, but the frequency of the common‐mode voltage of the reverse‐clamped inverter is three times that of the forward‐clamped inverter. The loop impedance of the reverse‐clamped inverter increases significantly at high frequency, so the leakage current suppression capability is better. Simulation and experiment platforms of the inverter systems are built. The obtained results verify the correctness of the theoretical analysis.
A survey of Blockchain technologies applied to software‐defined networking: Research challenges and solutions
Authors: Nam Nguyen Hai , Anh Tran Hai , Fowler Scott , Souihi Sami 
Published: November 2021

AbstractSoftware‐Defined Networking (SDN) brought a groundbreaking idea to facilitate network system management by decoupling and abstracting the Control plane and Data plane of traditional networks. The centralised control offers network administrators many benefits such as a global view of the network, programmability, dynamic updating of forwarding rules, and software‐based traffic analysis. The SDN architecture has been applied a lot in practice, and especially in Internet of Things (IoT) platforms. With the superiority of SDN, IoT devices can be managed and configured much more easily when combined. However, SDN also raises many challenges in terms of scalability, reliability, and security. Blockchain is another promising solution for secure information storage and transmission technology that operates without a centralised authority. Applying Blockchain technology into SDN can address some of the current issues of SDN by providing decentralised methods to authenticate exchanged network information. This study provides a comprehensive survey on Blockchain technologies applied to SDN in both security and non‐security fields. First, related studies and an overview of SDN and the background of Blockchain technology are presented. Then, the authors review how Blockchain technologies are applied in SDN from two perspectives: non‐security and security‐aware approaches. Finally, challenges and broader perspectives are discussed.
Functional Threshold Power Estimated from a 20-minute Time-trial Test
is Warm-up-dependent
Authors: Tramontin Artur Ferreira , Borszcz Fernando Klitzke , Costa Vitor 
Published: November 2021

AbstractThis study investigated the influence of different warm-up protocols on
functional threshold power. Twenty-one trained cyclists
(˙VO2max=60.2±6.8 ml·kg−1·min−1)
performed an incremental test and four 20-min time trials preceded by different
warm-up protocols. Two warm-up protocols lasted 45 min, with a 5-min
time trial performed either 15 min (Traditional) or 25 min
(Reverse) before the 20-min time trial. The other two warm-up protocols lasted
25 min (High Revolutions-per minute) and 10 min (Self-selected),
including three fast accelerations and self-selected intensity, respectively.
The power outputs achieved during the 20-min time trial preceded by the
Traditional and Reverse warm-up protocols were significantly lower than the High
Revolutions-per-minute and Self-selected protocols (256±30;
257±30; 270±30; 270±30 W, respectively).
Participants chose a conservative pacing strategy at the onset (negative) for
the Traditional and Reverse but implemented a fast-start strategy (U-shaped) for
the High revolutions-per-minute and Self-selected warm-up protocols. In
conclusion, 20-min time-trial performance and pacing are affected by different
warm-ups. Consequently, the resultant functional threshold power may be
different depending on whether the original protocol with a 5-min time trial is
followed or not.
Effect of Air Tamponade among Patients with Epiretinal Membranes and Intraretinal Cystoid Changes Undergoing Vitrectomy with Membrane Peeling – A Prospective
Randomized Trial
Authors: Leisser Christoph , Ruiss Manuel , Pilwachs Caroline , Hienert Julius , Stjepanek Kristina , Findl Oliver 
Published: November 2021

Abstract
Background The effect of air tamponade among patients undergoing vitrectomy with membrane peeling for removal of epiretinal membranes (ERM) is controversially discussed. The aim of
the present study was to analyze differences in outcomes between air tamponade and balanced salt solution (BSS) in a study population with preoperative intraretinal cystoid changes.
Patients and Methods This randomized study included patients scheduled for pars plana vitrectomy with membrane peeling owing to ERM and intraretinal cystoid changes. Air tamponade or
BSS at the end of surgery was applied according to preoperative randomization. Optical coherence tomography and best-corrected distance visual acuity (DCVA) measurements were performed
before surgery, 5 days after surgery, and 3 months after surgery.
Results From 96 patients included, 85 eyes had full follow-up and could be included for analysis. Median improvement of DCVA was + 16 EDTRS letters (IQR: 8 to 22) among patients with
BSS, while it was + 13 EDTRS letters (IQR: 8 to 17) among patients with air tamponade. There was a trend for better improvement of DCVA when BSS was left at the end of surgery, compared to
air tamponade, but not reaching statistical significance.
Conclusions There were no statistically significant differences concerning resorption of preoperative intraretinal cystoid changes, improvement of visual acuity, and final DVCA
between air tamponade and BSS.
Solvent- and Metal-Controlled Regiodivergent Synthesis of Tri­fluoromethylated Pyrazol-3-yl- and Pyrazol-5-ylphosphonates
Authors: Mitrofanov Alexander Yu. , Beletskaya Irina P. , Bychkova Valentina A. , Kalugin Danila A. 
Published: November 2021

AbstractConvenient approaches to the selective syntheses of trifluoro­methylated pyrazol-3-yl- and pyrazol-5-ylphosphonates have been developed based on solvent- and metal-controlled reaction of diethyl (4,4,4-trifluoro-3-oxobut-1-yn-1-yl)phosphonate and monosubstituted hydrazines.
On the role of intermolecular vibrational motions for ice polymorphs. III. Mode characteristics associated with negative thermal expansion
Authors: Tanaka Hideki , Yagasaki Takuma , Matsumoto Masakazu 
Published: November 2021

Low-pressure ice forms, such as hexagonal and cubic ice, expand on cooling below temperature 60 K. This negative thermal expansivity has been explored in terms of phonon frequency modulation with varying volume and attributed to the negative Grüneisen parameters unique mostly to tetrahedrally coordinated substances. However, an underlying mechanism for the negative Grüneisen parameters has not been known except some schematic analyses. We investigate in this study the characteristics of the intermolecular vibrational modes whose Grüneisen parameters are negative by examining the individual vibrational modes rigorously. It is found that the low frequency modes below 100 cm−1, which we explicitly show are mostly bending motions of three hydrogen-bonded molecules, necessarily accompany elongation of the hydrogen bond length at peak amplitudes compared with that at the equilibrium position in executing the vibrational motions. The elongation gives rise to a decrease in the repulsive interaction while an increase in the Coulombic one. The decrease in the repulsive interaction is relaxed substantially by expansion due to its steep slope against molecular separation compared with the sluggish increase in the Coulombic one, and therefore, the negative Grüneisen parameters are obtainable. This scenario is tested against some variants of cubic ice with various water potential models. It is demonstrated that four interaction-site models are suitable to describe the intermolecular vibrations and the thermal expansivity because of the moderate tendency to favor the tetrahedral coordination.