bluuebunny/crossref_metadata_2025_split huggingface dataset:
Esophageal carcinoma in achalasia patients managed with endoscopic submucosal dissection and peroral endoscopic myotomy: Japan Achalasia Multicenter Study
Authors: Sato Hiroki , Nishikawa Yohei , Abe Hirofumi , Shiwaku Hironari , Shiota Junya , Sato Chiaki , Sakae Hiroyuki , Ominami Masaki , Hata Yoshitaka , Fukuda Hisashi , Ogawa Ryo , Nakamura Jun , Tatsuta Tetsuya , Ikebuchi Yuichiro , Yokomichi Hiroshi , Terai Shuji , Inoue Haruhiro 
Published: November 2021

ObjectivesIndications for peroral endoscopic myotomy (POEM) and endoscopic submucosal dissection (ESD) in patients with achalasia concomitant with esophageal carcinoma (EC) are unclear. This study aimed to clarify the role of POEM in cases of achalasia concomitant with EC and to elucidate the indications for ESD and efficient surveillance for EC.MethodsWe conducted a multicenter cohort study at 14 hospitals in Japan, including 3707 cases of achalasia‐related esophageal motility disorders (EMDs). Factors contributing to EC risk, the characteristics of EC, and clinical outcomes of POEM/ESD were analyzed.ResultsIn patients undergoing POEM, screening and surveillance endoscopy throughout a 1‐year period resulted in diagnosis of 72.1% new EC cases. Of 62 patients with 123 ECs, 40.3% had multiple or metachronous lesions within 37.5 months. EC was predominantly observed in the middle thoracic esophagus (58.5%) and posteriorly (73.2%). POEM had comparable safety and efficacy in cases of concomitant EC even after ESD. Endoscopic en bloc resection was performed in 95.8% and 89.3% of ECs diagnosed before and after POEM, respectively (P = 0.351); however, ESD on the POEM‐line was impaired by fibrosis. Multivariate analysis revealed risk factors for EC, including regular alcohol consumption, a history of smoking, advanced age, and extended disease duration. Alcohol intake and smoking had a synergistic effect on EC development.ConclusionsScreening and surveillance of POEM help in detecting EC. ESD is feasible in achalasia, although on the POEM‐line is challenging. Surveillance endoscopy for EC is recommended for cases with specific risks and a history of ECs.
Establishment of culture and microinjection methods for false clownfish embryos without parental care
Authors: Yamanaka Sakuto , Okada Yosuke , Furuta Takeshi , Kinoshita Masato 
Published: November 2021

AbstractAnemonefish, including the false clownfish Amphiprion ocellaris, are attractive model organisms because of their unique features, such as sex change and brilliant color patterns in mutants. However, anemonefish are not widely used to study gene function using reverse genetic approaches owing to microinjection difficulties and subsequent rearing and hatching of embryos without parental care. A. ocellaris embryos are spawned on a hard substrate and cared for by their parents until hatching. However, the eggs need to be detached from the substrate and raised without their parents to perform successful microinjection. We established a method to culture and hatch A. ocellaris embryos without spawning substrates or parental care. We found that changing water and generating water flow are critical for culturing the embryos, and that water flow (as physical stimulation) and complete darkness in the dark period are necessary for successful hatching. We further investigated the effectiveness of microinjection into the yolk sac of fertilized eggs rather than into the cytoplasm, which makes microinjection easier. A reporter RNA injected into the yolk sac was transferred to the cytoplasm and translated, indicating that yolk sac microinjection is an efficient alternative as has been used for zebrafish. These findings highlight the potential of A. ocellaris as an experimental model organism for reverse genetics, and our methods could be applied to other anemonefish species.
Like it or not! Brand communication on social networking sites triggers consumer‐based brand equity
Authors: Arya Vikas , Paul Justin , Sethi Deepa 
Published: November 2021

AbstractThis study examines how brand communication influences consumer‐based brand equity (BEQ) through social networking sites in the presence of brand attachment (BAT) as a mediator. The outcomes related to consumer‐BEQ, such as consumers’ pay intention and loyalty to a brand and a brand’s vocal ability, are also explored in this study. An empirical investigation for 498 responses was carried using Smart‐PLS, Process‐macro & artificial neural network modeling based hybrid approach. The analysis indicates that brand consumer‐BEQ is high when a brand’s communication on social media platforms is positive. A strong mediating role of BAT is confirmed. The study is unique in terms of explaining the role of brand communication on social networking sites and its impact on consumer‐BEQ in the presence of BAT as a mediator. While focusing on Millennials’ tech‐savvy characteristics and considering SNSs as an advanced tool for brand communication, brands should refine their marketing strategy.
Association between nighttime urinary frequency and sleep problems among Japanese adolescents
Authors: Matsushima Eriko , Otsuka Yuichiro , Itani Osamu , Matsumoto Yuuki , Kaneita Yoshitaka 
Published: November 2021

ObjectiveTo conduct a cross‐sectional study to investigate the relationship between nighttime urinary frequency and sleep problems in Japanese adolescents.MethodsA self‐administered questionnaire survey was conducted among 1757 adolescents (mean age 15.6 ± 1.1 years; 49.0% boys). The survey assessed sleep problems (sleep duration, sleep quality, and insomnia symptoms), nighttime urinary frequency, eating habits (breakfast, late‐night eating, energy drink consumption), problematic internet use, engagement in club activities, and mental health. We analyzed the association between nighttime urinary frequency and sleep problems using descriptive statistics and logistic regression models.ResultsThe response rate was 99.6% (1699 students). The prevalence of nighttime urinary frequency ≥2 was 5.6% in boys and 4.6% in girls. The prevalence rates of sleep problems were: insomnia, 16.4%; difficulty initiating sleep, 11.8%; difficulty maintaining sleep, 5.9%; early‐morning awakening, 5.4%; and poor sleep quality, 19.9%. Analysis of the relationship with sleep problems differentiating between zero, one, and two nighttime urinations showed that an increase in nighttime urinary frequency corresponded to an increase in the prevalence of insomnia, difficulty initiating sleep, and difficulty maintaining sleep. Logistic regression analysis also showed that insomnia, difficulty initiating sleep, and difficulty maintaining sleep had a linear, significant relationship with increased nighttime urinary frequency.ConclusionThis study suggests that adolescents with high nighttime urinary frequency experience increased sleep problems. Consideration of urinary frequency is required when tackling adolescent sleep problems.
Medicare and telehealth: The impact of COVID‐19 pandemic
Authors: Hamadi Hanadi Y. , Zhao Mei , Haley Donald Rob , Dunn Ajani , Paryani Shyam , Spaulding Aaron 
Published: November 2021

AbstractStudy RationaleThe swift progression of the COVID‐19 pandemic appeared to facilitate the increase in telehealth utilization. However, it is clear neither how telehealth was offered by providers nor how it was used by patients during this time of unusual and rapid change within the health industry.AimTo investigates the telehealth utilization patterns of Medicare beneficiaries during the height of the COVID‐19 pandemic.Methods and MaterialsA cross‐sectional study design was used to examine the responses of 9686 Medicare beneficiaries to the Centers for Medicare and Medicaid Services (CMS) Medicare Current Beneficiary Survey, Fall 2020 COVID‐19 Supplement. Multiple logistic regression analyses were conducted to examine the relationship between telehealth offering and beneficiaries' sociodemographic variables.ResultsOver half (58%) of primary care providers provided telehealth services, while only 26%–28% of specialists did. Less than 8% of Medicare beneficiaries reported that they were unable to obtain care because of COVID‐19.ConclusionsThis research found that changes in Medicare policy, associated with CMS' declaration of telehealth waivers during the Public Health Emergency (PHE), likely increased the proliferation and utilization of telehealth services during the COVID‐19 pandemic, providing important access to care for certain populations. With the impending conclusion of the PHE, policymakers must 1) ascertain which elements of the new telehealth landscape will be retained, 2) modernize the regulatory, accreditation and reimbursement framework to maintain pace with care model innovation and 3) address disparities in access to broadband connectivity with a particular focus on rural and underserved communities.
Family caregiver competence in managing behavioral and psychological symptoms of dementia: A concept synthesis
Authors: Jung Sua , Song Jun‐Ah , Kim Jiyeon , Cheon Hongjin , Kim Jiyeon 
Published: November 2021

AbstractAimThis study aimed to identify the attributes of “family caregiver competence in managing behavioral psychological symptoms of dementia”.MethodsSix electronic databases were searched for studies published between January 1990 and June 2017 with the key words “dementia”, “behavioral psychological symptoms of dementia”, “caregiver”, “coping (managing)”, and “competence”. From the final fully reviewed 26 articles, descriptions related to family caregiver's dealing with behavioral psychological symptoms of dementia were extracted first. Then, based on Walker and Avant's concept synthesis, the concept of “family caregiver competence in managing behavioral psychological symptoms of dementia” was explored.ResultsFour attributes, namely “Judging”, “Empathizing”, “Adjusting”, and “Reflecting”, comprised of ten categories were identified as constituting the concept of family caregiver competence in managing the behavioral psychological symptoms of dementia. As a meta competence, “reflecting” may play a significant role in improving family caregiver competence by interacting with the other dimensions of competence in managing symptoms.ConclusionsBased on the suggested conceptual model, education or training programs could be developed to improve family caregiver competence in managing behavioral psychological symptoms of dementia. To refine the attributes found in this study, field studies including observations of and interviews with family caregivers need to be conducted. Studies exploring the associations between these attributes are also of value.
Reaching for the stars: When does basic research collaboration between firms and academic star scientists benefit firm invention performance?
Authors: Colen Linde , Belderbos René , Kelchtermans Stijn , Leten Bart 
Published: November 2021

AbstractWhile their expertise and scientific excellence make academic star scientists attractive collaboration partners for firms, this study indicates that firms face difficulties in capturing value from collaborations with academic stars. Stars are time constrained, may be less committed to commercialization, and can be a source of undesired knowledge spillovers to other firms. The purpose of this study is to recognize the contingencies under which collaboration with star scientists is positively associated with a firm's ability to produce valuable patents (invention performance). We analyze a panel data set on the collaborations in basic research (publication data) and invention performance (patent output) of 60 prominent pharmaceutical firms. We find that basic research collaboration with academic stars is on average not associated with a performance premium above the overall positive influence of collaborating with academia. We only observe this premium if the star scientist abstains from simultaneous collaboration with other firms (‘dedication’) and extend her collaboration with the firm to involve not only basic but also applied research (‘translation’). Extending prior work that has focused on corporate star scientists, we find that if the collaboration involves an internal firm star scientist, a translational contribution of the academic star is no longer a prerequisite, and may even be detrimental to inventive performance. Our findings inform the literatures on industry‐science links and firms’ (scientific) absorptive capacity by revealing the crucial contingencies for firms to benefit from partnering with the best and brightest among academic scientists.
Periodontal tissue engineering using an apatite/collagen scaffold obtained by a plasma‐ and precursor‐assisted biomimetic process
Authors: Kanemoto Yukimi , Miyaji Hirofumi , Nishida Erika , Miyata Saori , Mayumi Kayoko , Yoshino Yuto , Kato Akihito , Sugaya Tsutomu , Akasaka Tsukasa , Nathanael Arputharaj Joseph , Santhakumar Syama , Oyane Ayako 
Published: November 2021

AbstractBackground and objectivesIn the treatment of severe periodontal destruction, there is a strong demand for advanced scaffolds that can regenerate periodontal tissues with adequate quality and quantity. Recently, we developed a plasma‐ and precursor‐assisted biomimetic process by which a porous collagen scaffold (CS) could be coated with low‐crystalline apatite. The apatite‐coated collagen scaffold (Ap‐CS) promotes cellular ingrowth within the scaffold compared to CS in rat subcutaneous tissue. In the present study, the osteogenic activity of Ap‐CS was characterized by cell culture and rat skull augmentation tests. In addition, the periodontal tissue reconstruction with Ap‐CS in a beagle dog was compared to that with CS.MethodsThe plasma‐ and precursor‐assisted biomimetic process was applied to CS to obtain Ap‐CS with a low‐crystalline apatite coating. The effects of apatite coating on the scaffold characteristics (i.e., surface morphology, water absorption, Ca release, protein adsorption, and enzymatic degradation resistance) were assessed. Cyto‐compatibility and the osteogenic properties of Ap‐CS and CS were assessed in vitro using preosteoblastic MC3T3‐E1 cells. In addition, we performed in vivo studies to evaluate bone augmentation and periodontal tissue reconstruction with Ap‐CS and CS in a rat skull and canine furcation lesion, respectively.ResultsAs previously reported, the plasma‐ and precursor‐assisted biomimetic process generated a low‐crystalline apatite layer with a nanoporous structure that uniformly covered the Ap‐CS surface. Ap‐CS showed significantly higher water absorption, Ca release, lysozyme adsorption, and collagenase resistance than CS. Cell culture experiments revealed that Ap‐CS was superior to CS in promoting the osteoblastic differentiation of MC3T3‐E1 cells while suppressing their proliferation. Additionally, Ap‐CS significantly promoted (compared to CS) the augmentation of the rat skull bone and showed the potential to regenerate alveolar bone in a dog furcation defect.ConclusionAp‐CS fabricated by the plasma‐ and precursor‐assisted biomimetic process provided superior promotion of osteogenic differentiation and bone neoformation compared to CS.
Plant neighbours can make or break the disease transmission chain of a fungal root pathogen
Authors: Ampt Eline A. , van Ruijven Jasper , Zwart Mark P. , Raaijmakers Jos M. , Termorshuizen Aad J. , Mommer Liesje 
Published: November 2021

SummaryBiodiversity can reduce or increase disease transmission. These divergent effects suggest that community composition rather than diversityper sedetermines disease transmission. In natural plant communities, little is known about the functional roles of neighbouring plant species in belowground disease transmission.Here, we experimentally investigated disease transmission of a fungal root pathogen (Rhizoctonia solani) in two focal plant species in combinations with four neighbour species of two ages. We developed stochastic models to test the relative importance of two transmission‐modifying mechanisms: (1) infected hosts serve as nutrient supply to increase hyphal growth, so that successful disease transmission is self‐reinforcing; and (2) plant resistance increases during plant development.Neighbouring plants either reduced or increased disease transmission in the focal plants. These effects depended on neighbour age, but could not be explained by a simple dichotomy between hosts and nonhost neighbours. Model selection revealed that both transmission‐modifying mechanisms are relevant and that focal host–neighbour interactions changed which mechanisms steered disease transmission rate.Our work shows that neighbour‐induced shifts in the importance of these mechanisms across root networks either make or break disease transmission chains. Understanding how diversity affects disease transmission thus requires integrating interactions between focal and neighbour species and their pathogens.
How local governments prioritize multiple conflicting goals: Beyond the sole‐goal perspective
Authors: Chen Shaowei , Jia Kai 
Published: November 2021

AbstractUnderstanding how public organizations prioritize goals is crucial in studying goal‐setting in the public sector. However, the extant literature has mostly adopted a sole‐goal perspective and neglected the influences of the interplay among multiple goals. This article extends the literature by going beyond the sole‐goal perspective and adopting a multigoal perspective to further explore the complexities in public organizations' goal prioritization when facing multiple conflicting goals. Drawing on the theoretical perspectives of performance information use and interorganizational interactions, the main arguments of this study are twofold. First, an organization's prioritization of a particular goal will be positively associated with the performance gap in its conflicting goal. Second, organizations tend to adopt a differentiation strategy in the prioritization of multiple conflicting goals. Empirical findings based on the investigation of Chinese city‐level governments' prioritization of environmental goals when confronting conflict between environmental protection and economic development goals support our arguments.
Alternative pathway to photorespiration protects growth and productivity at elevated temperatures in a model crop
Authors: Cavanagh Amanda P. , South Paul F. , Bernacchi Carl J. , Ort Donald R. 
Published: November 2021

SummaryAdapting crops to warmer growing season temperatures is a major challenge in mitigating the impacts of climate change on crop production. Warming temperatures drive greater evaporative demand and can directly interfere with both reproductive and vegetative physiological processes. Most of the world’s crop species have C3 photosynthetic metabolism for which increasing temperature means higher rates of photorespiration, wherein the enzyme responsible for fixing CO2 fixes O2 instead followed by an energetically costly recycling pathway that spans several cell compartments. In C3 crops like wheat, rice and soybean, photorespiration translates into large yield losses that are predicted to increase as global temperature warms. Engineering less energy‐intensive alternative photorespiratory pathways into crop chloroplasts drives increases in C3 biomass production under agricultural field conditions, but the efficacy of these pathways in mitigating the impact of warmer growing temperatures has not been tested. We grew tobacco plants expressing an alternative photorespiratory pathway under current and elevated temperatures (+5 °C) in agricultural field conditions. Engineered plants exhibited higher photosynthetic quantum efficiency under heated conditions than the control plants, and produced 26% (between 16% and 37%) more total biomass than WT plants under heated conditions, compared to 11% (between 5% and 17%) under ambient conditions. That is, engineered plants sustained 19% (between 11% and 21%) less yield loss under heated conditions compared to non‐engineered plants. These results support the theoretical predictions of temperature impacts on photorespiratory losses and provide insight toward the optimisation strategies required to help sustain or improve C3 crop yields in a warming climate.
Eruptive nevi in a patient with constitutional mismatch repair deficiency (CMMRD)
Authors: Vassantachart Janna M. , Zacher Natasha C. , Teng Joyce M. C. 
Published: November 2021

AbstractBiallelic mutations in the DNA mismatch repair genes MLH1, MSH2, MSH6, or PMS2 result in one of the most aggressive genetic cancer conditions, constitutional mismatch repair syndrome (CMMRD). We present a case of a 10‐year‐old boy with biallelic MSH6 mutation and systemic lupus erythematosus with eruptive melanocytic nevi after receiving chemotherapy for mediastinal T‐cell lymphoblastic lymphoma.
Influence of dietary L‐carnitine and lysine–methionine levels on reproductive performance and blood metabolic constituents of breeder ducks
Authors: Mirzaei Maryam , Bouyeh Mehrdad , Zahedi Afshin , Seidavi Alireza , Khan Rifat Ullah , Tufarelli Vincenzo , Laudadio Vito , Abd El‐Hack Mohamed E. , Ragni Marco , Taha Ayman E. , Swelum Ayman A. 
Published: November 2021

AbstractThe present study aimed to evaluate the influence of dietary supplementation of different levels of L‐carnitine and/or lysine–methionine (Lys‐Met) on reproductive performance of breeder ducks. Three L‐carnitine (0, 75 and 150 mg/kg) and three lysine–methionine (100%, 110% and 120% above the NRC (Nutrient requirements of poultry, 1994, National Academy Press) recommendations) levels were fed to 180 breeder ducks (144 females and 36 males) in a completely randomized design for 49 days. Laying performance and reproductive traits were evaluated; additionally, uric acid, total protein total, triglycerides, total cholesterol, low‐density lipoprotein, high‐density lipoprotein, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were assessed. The Lys‐Met above 100% NRC (Nutrient requirements of poultry, 1994, National Academy Press) recommendations with or without L‐carnitine improved feed utilization (p < .05). Furthermore, Lys‐Met above 100% recommendations without L‐carnitine improved egg fertility and hatchability. Fertility and hatchability improved in breeders fed on L‐carnitine with 120% Lys‐Met (p < .05). Serum glucose increased and total cholesterol reduced on 100% Ly‐Met without L‐carnitine or 110% Ly‐Met with 150 mg L‐carnitine (p < .05). Glucose was reduced, while total cholesterol increased on 75 mg L‐carnitine and 100% Lys‐Met (p < .05). Increasing Lys‐Met without L‐carnitine reduced serum protein (p < .05). Albumin and ALT increased on 75 mg L‐carnitine–100% Lys‐Met and reduced on 150 mg L‐carnitine–120% Lys‐Met (p < .05). There were no interaction effects on globulin, uric acid and AST (p > .05). Thus, based on findings, breeder ducks responded to dietary Lys‐Met more efficiently than L‐carnitine; however, more research is needed to evaluate also economic aspects related to L‐carnitine dietary supplementation.