bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse events during immunotherapy in Slovenian patients with metastatic melanoma reveal a positive correlation with better treatment outcomes
Authors: Mesti Tanja , Ceplak Mencin Vid , Mileva Boshkoska Biljana , Ocvirk Janja 
Published: May 2021

Abstract

Background
Immunotherapy with CTLA-4 inhibitors and PD1 checkpoint inhibitors has initiated a breakthrough in the treatment and prognosis of patients with metastatic melanoma. The survival of these patients has increased from the expected survival time of less than 12 months to at least forty months. However, immunotherapy with either anti-CTLA-4 antibodies or PD1 inhibitors alone or in combination has a broad palette of significant immune-related adverse events. The aim of the study was to assess the correlation of immune-related adverse events with treatment outcomes defined as significant differences in the overall response rate (ORR) and progression-free survival (PFS) of patients, who developed immune-related adverse events during immunotherapy.

Patients and methods
A retrospective analysis of patients with metastatic melanoma treated with immunotherapy in 2020 at the Oncology Institute of Ljubljana was performed. Only patients with radiological evaluation of the immunotherapy response were included. The patients were divided into two cohorts: a cohort of patients with immune-related adverse events (irAE group) and a cohort of patients with no immune-related adverse events (NirAE group). Significantly better overall response and progression-free survival in the irAE cohort defined the primary aim of our study. To investigate the differences in progression-free survival between the irAE cohort and NirAE cohort, we used survival analysis. In particular, a Cox proportional hazards model with covariates of time to progression and adverse events was used for survival analysis. The Kruskal-Wallis H-test was applied, and a p-value of p <= 0.05 was considered the cut-off point for a statistically significant difference between the groups.

Results
Among the 120 patients treated with immunotherapy, radiological response evaluation was performed for 99 patients: 38 patients in the irAE cohort and 61 patients in the NirAE cohort. The ORRs for the irAE and NirAE cohorts were 57% and 37%, respectively. The PFS was significantly better for the irAE cohort (301.6 days) than for the NirAE cohort (247.29 days). The results of the survival regression analysis showed a significant increase in the survival probability from less than 60% for the NirAE cohort to almost 80% for the irAE cohort.

Conclusions
Patients with metastatic melanoma treated with immunotherapy who developed immune-related adverse events showed better treatment outcomes with longer times to disease progression and better overall response rates than patients treated with immunotherapy who did not develop immune-related adverse events, with a significant increase in the survival probability from less than 60% for the NirAE cohort to almost 80% for the irAE cohort.
Neural Correlates of Mental State Decoding in Dysphoria: An Event‐Related Potential Study
Authors: Wong Angelita 
Published: May 2021

Depression is often associated with profound social and interpersonal functioning impairments. Negative interpersonal experiences may lead depressed individuals to withdraw from social interaction, which may in turn exacerbate the depression state (Rippere, 1980). As a result, it is of theoretical and clinical importance to understand the mechanisms underlying these social deficits. Researchers have applied the theory‐of‐mind framework to better understand the impaired social functioning in depressed individuals. Theory of mind refers to the everyday ability to attribute mental states (i.e., beliefs, desires, emotions) to others to both understand and predict their behaviour (Wellman, 1990). Research has found that individuindividuals with dysphoria (i.e. elevated scores on a measure of depression symptoms, but not necessarily a diagnosis of clinical depression) demonstrate enhanced mental state judgments (Harkness, Sabbagh, Jacobson, Chowdrey, & Chen, 2005). This study will determine neural mechanisms that may underlie this phenomenon by examining whether differences in brain activity exist between dysphoric and nondysphoric groups during mental states decoding. I will record electrophysiological data while participants are judging the mental states from pictures of eyes. Based on previous research (Sabbagh, Moulson, & Harkness, 2004), I anticipate that mental state decoding will be associated with the right inferior frontal and right anterior temporal regions of the brain. Furthermore, I hypothesize that dysphoric individuals will have greater activations in these brain regions and make significantly more accurate judgments than nondysphoric individuals when making mental state judgments.
Model Kapasitas Petani Padi Sawah dalam Mendukung Ketahanan Pangan Berkelanjutan di Kabupaten Tangerang
Authors: Saleh Khaerul , Suherman Suherman 
Published: May 2021

Penelitian ini bertujuan menganalisis tingkat Kapasitas Petani Padi Sawah di Kabupaten Tangerang dan faktor-faktor penentu yang dapat mempengaruhi peningkatan kapasitas Petani padi sawah dalam mendukung ketahanan Pangan Berkelanjutan di Kabupaten Tangerang. Populasi dalam penelitian ini adalah Petani padi sawah dan berada di lokasi penelitian. Lokasi penelitian di tiga Balai Penyuluhan Pertanian (BPP) yakni BPP Kronjo, BPP Tegalkunir dan BPP Sukatani. Desain penelitian menggunakan pendekatan kualitatif dan kuantitatif dengan melibatkan 150 responden yang mewakili tiga BPP, data yang dikumpulkan adalah data primer dan data skunder. Data primer dikumpulkan melalui wawancara dengan menggunakan kuseioner, wawancara mendalam, observasi dan studi dokumentasi. Data tersebut terdiri atas karakteristik responden (ξ1); Inovasi teknologi (ξ2); Kegiatan Penyuluhan (ξ3); Dukungan Kelembagaan Lokal (ξ4); Kapasitas (η1); dan Keahana pangan Berkelanjutan (η2). Pemilihan responden dilakukan secara proporsional random sampling (proportionally random sampling) berdasarkan kriteria penelitian. Analsis data menggunakan statistik deskriptif, one way ANOVA dan Struktural Equation Modeling (SEM). Hasil penelitian menunjukkan bahwa kapasitas Petani Padi sawah berada pada kategori sedang. Unsur yang paling besar memepengaruhi tingkat kapasitas adalah Dukungan Kelembagaan Lokal sebesar 0,44 (65,25 persen) Kegiatan Penyuluhan sebesar 0.24 (45,55 persen) dan karakteristik responden sebesar 0.18 (30.75 persen) melalui lama pendidikan formal. Pendidikan non formal dan penguasaan lahan usahataninya. Sedangkan ketahanan pangan berkelanjutan depengaruhi oleh Inovasi Teknologi sebesar 0,29 (47,25 perses) serta tingkat Kapasitas petani sebesar 0.18 (30.75 persen).
Mid-Ordovician subduction, obduction, and eduction in western Newfoundland; an eclogite problem
Authors: Dewey J.F. , Casey J.F. 
Published: May 2021

Abstract.
The narrow, short-lived Taconic-Grampian Orogen occurs along the north-western margin of the Appalachian-Caledonian Belt from, at least, Alabama to Scotland, a result of the collision of a series of early Ordovician oceanic island arcs with the rifted margin of Laurentia. The present distribution of Taconian-Grampian ophiolites is unlikely to represent a single fore-arc from Alabama to Scotland colliding at the same time with the continental margin along its whole length; more likely is that there were several Ordovician arcs with separate ophiolites. The collision suture is at the thrust base of obducted fore-arc ophiolite complexes, and obduction distance was about two hundred kilometres. Footwalls to the ophiolites are, sequentially towards the continent, continental margin rift sediments and volcanics and overlying rise sediments, continental shelf slope carbonates, and sediments of foreland flexural basins. The regionally-flat obduction thrust complex between the ophiolite and the rifted Laurentian margin is the collision suture between arc and continent. A particular problem in drawing tectonic profiles across the Taconic-Grampian Zone is several orogen-parallel major strike-slip faults, both sinistral and dextral, of unknown displacements, which may juxtapose portions of different segments. In western Newfoundland, most of the Grenville basement beneath the Fleur-de-Lys metamorphic complex (Neoproterozoic to early Ordovician meta-sediments) was eclogitised during the Taconic Orogeny and separated by a massive shear zone from the overlying Fleur-de-Lys, which was metamorphosed at the same time but in the amphibolite facies. The shear zone continued either to a distal intracontinental “subduction zone” or to the main, sub-fore-arc, subduction zone beneath which the basement slipped down to depths of up to seventy kilometres at the same time as the ophiolite sheet and its previously-subcreted metamorphic sole were being obducted above. Subsequently, the eclogitised basement was returned to contact with the amphibolite-facies cover by extensional detachment eduction, possibly enhanced by subduction channel flow, which may have been caused by slab break-off and extension during subduction polarity flip. Although the basal ophiolite obduction thrust complex and the Fleur-de-Lys-basement subduction-eduction surfaces must have been initially gently-dipping to sub-horizontal, they were folded and broken by thrusts during late Taconian, late Ordovician Salinic-Mayoian, and Acadian shortening.
Economic Entity Concept, Penata Keuangan dan Aplikasi Lamikro Era Industri 4.0 (UMKM Provinsi Kepulauan Bangka Belitung)
Authors: Irawan Wawan , Wardhani Rulyanti Susi 
Published: May 2021

This study aims to determine the importance of Financial Arrangement, Entity Concept, and Lamikro Application in Micro, Small, and Medium Enterprises (MSMEs) in Bangka Belitung Province. The data analysis technique used in this study is to use Importance Performance Analysis (IPA), which describes the condition of MSMEs in Bangka Belitung Province regarding aspects of financial arrangement, entity concept, and technology the use of the Lamikro application. The results show that MSMEs in Bangka Belitung Islands Province in managing finances still use manuals. Still, some are using applications to consider it not a priority or important in managing finances. Furthermore, the economic entity concept and Lamikro application are still lacking in use, so they are still considered more important and priority in supporting MSMEs' performance in the Province of Bangka Belitung Islands.
Keywords: Financial Structuring, Entity Concept (Economic Entity Concept), Lamikro Application
Diagnóstico Imagenológico de la Neurocisticercosis por Resonancia Magnética: Estudio de un caso.
Authors: Escariz Liliam Iris , Chávez-Guerra Víctor , Bazurto Moreira Glen , Farfán Zambrano Ximena , Cedeño Arteaga Joshelyn 
Published: May 2021

La Neurocisticercosis es causada por la forma larvaria de la Taenia solium (tenia del cerdo), esta se adquiere cuando la persona ingiere los huevecillos por alimentos con carne de cerdo mal cocinada, estas larvas se evaginan en el intestino delgado, el escólex se adhiere a la pared intestinal y el cuerpo del parásito comienza a crecer, provocando una inflamación en la zona de implantación. Este estudio de caso presenta un paciente que ingresa por consulta, con cuadro clínico de aproximadamente una semana de evolución caracterizado con parestesia esporádica del lado derecho, consciente, hipotenso y bradicárdico. Sin antecedentes patológicos familiares. Se le realiza Tomografía y Resonancia Magnética para conocer origen etiológico de la parestesia, diagnosticándosele Neurocisticercosis. Los diferentes métodos de imagen permiten detectar las manifestaciones, siendo útiles en el diagnóstico, seguimiento a largo plazo y detección de sus posibles complicaciones.
COLONOSCOPIC EXAMINATION PROFILE AT THE UKI HOSPITAL, EAST JAKARTA FROM JANUARY 2014 - JULY 2015
Authors: Simanjuntak Tiroy Sari B. 
Published: May 2021

Colonoscopy is a procedure, which is done using a Colonoscope. The technique implemented in evaluating the colon: Picture of the colon, derived from the computed tomography or magnetic resonance imaging, is processed (reconstructed) by the computer to reveal colon lumen in 3D. Colonoscopy is used to diagnose diseases found in the large intestine; however, not all kinds of ailments in the large intestine can be diagnosed by colonoscopy. This study aims to determine the colonoscopy procedure profile in UKI Hospital East Jakarta from 2014 to July 2015. The design used by this research is a descriptive study, which is retrospective to the population of patients that have had a colonoscopy in UKI Hospital from January 2014 to July 2015. This study reveals the colonoscopy procedure profile at UKI Hospital, East Jakarta from January 2014 to July 2015: the most dominant age of the patients receiving colonoscopy is between 50 and 59. Patients are males of Batak ethnicity with a background of high school education. These males' main symptom is abdominal pain, which leads to colitis infection as the primary diagnosis. This study shows that patients who have the colonoscopy done upon them are patients with the age span of 50–59. Most are males due to the factor of lifestyle and stress condition. Background of the patients is working males with high school diplomas. The main complaint found among these patients is abdominal pain. Colitis infection is found to be the primary diagnosis among them.
Are Indonesian Farmers a Good Manager? A study on Entrepreneurial and Marketing Orientation to Farm Business Performance in Indonesia
Authors: Haryati Novi 
Published: May 2021

Farming is including a business entity because its activities include not only planting on land but also being able to maintain relationships that focus on business interests, such as increased sales and income. As the actor in the business, they are required to be able to have marketing and entrepreneurial skills so that their business performance can be sustainable. The purpose of the research is to understand the relationship between marketing and entrepreneurship to the farming performances, with organization innovation as intervening variables. It is quantitative research and has been conducted in Singosari sub district Malang, Indonesia. Analysis was done by SEM-PLS while 40 farmers were chosen purposively as respondent. The result shows that the Indonesian farmer has basic marketing and entrepreneurship orientation. Both of them has positive and highly significant with the value of 0,41 and 0,53 to farming performance. As an intervening variable, Organizational innovation has positively associated with farmer’s performance. Improving the human resources of farmers has been a very important aspect of sustainable business and human resources itself in Agriculture. An experienced and trained farmer will be able to keep working event in an unstable situation.
Pemanfaatan lubang biopori sebagai resapan air hujan dan kompos alami di wilayah Kelurahan Penurunan Kota Bengkulu
Authors: Marwanto Andriana , Mualim Mualim 
Published: May 2021

Most of the rainwater that falls to the earth cannot seep directly into the ground and eventually becomes runoff or what is often called surface water. Rainwater runoff that is not handled properly will cause various problems for the community, especially flooding. The negative impact of changing or losing catchment areas is that they cannot withstand the flow rate of water due to rainfall, causing stagnation of water or even flooding. Flood hazard in residential areas often occurs due to changes in land use from infiltration areas to watertight areas. Solutions that can be used to overcome flood problems, especially for dense residential areas or those with minimal rainwater infiltration, can be done by using biopore technology.
The method used in this community service activity is to provide community empowerment regarding the use of biopore holes as rainwater infiltration and natural compost with demonstrations and practice of making biopore holes. The result of this community service activity is that the activity participants are able to make biopore holes as rainwater infiltration and natural compost which can then make biopore holes around the home page and share information and skills with other communities so that they can reduce standing water when it rains and can take advantage of compost management.
Key words: biopore holes, infiltration water and compost
Impact of Anaemia on the Severity of Acute Bronchiolitis in Infants
Authors: Çelik Elif , Çelik Serkan Fazlı , Güngör Şükrü , Dursun Adem 
Published: May 2021

Introduction: Although anaemia is a predisposing factor in the occurrence of lower respiratory tract infections, there is limited data about the relationship between anaemia and acute bronchiolitis in infants. The aim of this study is to determine whether anaemia is an independent clinical condition increasing the severity of acute bronchiolitis in infants.
Methods: This retrospective study was conducted on 163 infants (101 acute bronchiolitis and age and sex matched 62 controls), aged between one month to two years. According to the clinical severity of the disease, patients were divided as having mild, moderate and severe acute bronchiolitis. Haemoglobin (Hb) level was considered low when below 11 gm/dL, which is less than 2 standard deviation (SD).
Results: Median Hb and mean cell haemoglobin concentration (MCHC) levels were significantly lower in acute bronchiolitis patients than controls {10.1 gm/dL (9.6 - 10.6 gm/dL) vs. 11.2 gm/dL (10.6 - 12.1 gm/dL); p < 0.001)}, and {33.6 (32.5 - 34.1 gm/dL) vs. 34 gm/dL (33.1 - 34.5 gm/dL) p = 0.012}. Conversely, median red cell distribution width (RDW) was higher {14.4% (13.5 - 15.6%) vs. 14.1% (13.1-15%)}. When evaluated by logistic regression analysis, the risk of severe bronchiolitis increased 10 times in acute bronchiolitis patients with a Hb value ≤ 10 gm/dL. Also, there was a significant negative correlation between Hb level and bronchiolitis severity (r :- 0.423, p < 0.001). Furthermore, the patients who had Hb value under 9.95 gm/dL had risk of more severe bronchiolitis with 73.7% sensitivity and 83.3% specificity than other patients.
Conclusions: Anaemic infants are more susceptible to acute bronchiolits and as the degree of anaemia increases, they are more severely affected.
Comparison of Efficacy of First Haemodialysis Session for Correction of Metabolic Disturbances in Acute Kidney Injury and Chronic Kidney Disease in Children
Authors: Verma Shubham , Abhishek Abhinay , Mishra Om Prakash , Singh Ankur , Prasad Rajniti 
Published: May 2021

Introduction: Acute kidney injury and chronic kidney disease present with various complications like electrolyte disturbances, metabolic acidosis and fluid overload in children. The objective of the study was to compare the efficacy of the first session of haemodialysis in children with acute kidney injury stage 3 and chronic kidney disease G5 treated by dialysis for immediate recovery of renal functions in terms of reduction in the level of azotemia, correction of fluid and electrolyte imbalances, metabolic acidosis, and improvement in clinical status.
Methods: This was a cross-sectional comparative observational study conducted on 13 patients of acute kidney injury stage 3 and 46 patients with chronic kidney disease G5, who required haemodialysis. Their clinical assessment, fluid status, renal function tests, electrolyte, bicarbonate were done at admission and completion of the first session of heamodialysis.
Results: The age group of children was six to 16 years (median 11.4 years). There were six males (46%) and seven females (54%) in the acute kidney injury group and 29 (63%) males and 17 (37%) females in chronic kidney disease G5 groups. Sepsis (31%) and glomerulonephritis (31%) were common etiologies detected for acute kidney injury while in chronic kidney disease G5, congenital anomalies of the kidney and the urinary tract were the commonest (50%). There were significant reductions in the levels of serum urea and creatinine and a rise in blood pH, bicarbonate level, and base excess following the first session of haemodialysis in comparison to pre-dialysis values in both AKI and CKD.
Conclusions: The study demonstrated improvement in the clinical parameters and biochemical parameters equally after the first dialysis sessions in both groups. This is one of the effective renal replacement therapy and should be instituted wherever indicated to improve the immediate outcome of the patients.
A APLICAÇÃO DO PRINCÍPIO DA INSIGNIFICÂNCIA PELA AUTORIDADE POLICIAL
Authors: Da Silva Neto Luis Gonzaga , Santos da Luz Ana Carolina 
Published: May 2021

O presente artigo tem por objetivo analisar a aplicação do princípio da insignificância pela autoridade policial no momento da lavratura do auto de prisão em flagrante, bem como no momento de decidir acerca da instauração da portaria que inaugura o inquérito policial, tendo em vista que este princípio vem ganhando bastante notoriedade no nosso ordenamento jurídico. Sob a ótica de uma Constituição Cidadã, defensora dos direitos democráticos, o direito penal e o processual penal encontram-se em um período de grande evolução, e acompanhando esta transformação, a doutrina e a jurisprudência vêm se firmando no sentido de limitar o poder punitivo do Estado, o qual embora detenha o poder-dever de punir os cidadãos que cometem ilícitos, somente poderá agir na busca de uma pretensão punitiva penal, quando estiver diante de uma ofensa a um bem jurídico penalmente tutelado. No entanto, apenas esta ofensa não é necessária para a intervenção estatal, pois sob esta nova ótica de direito penal moderno, a pretensão punitiva do Estado deve se dar, apenas quando a ofensa trouxer um mínimo de lesividade, para que, do ponto de vista social, ela possa demandar uma repressão penal. O delegado de polícia, tendo em vista a importância de sua função, não deve se limitar a um formalismo mecânico no momento de analisar os casos que lhe são apresentados, pois quando assim procede, reduz sua missão a um simples mecanismo automático. Portanto, o intuito deste trabalho é expor o princípio da insignificância e demonstrar a possibilidade de sua aplicação pela autoridade policial, tendo em vista que ele geralmente é o operador do direito que faz o primeiro contato com o caso concreto, dessa forma, podendo sanar várias injustiças e ainda ajudar a diminuir a morosidade do judiciário brasileiro.