bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Digital Technology Framework: Through the Lenses of a Qualitative Study
Authors: Zainal Saiful Izwan , Saimin Rahimah 
Published: December 2021

The need for technologically inclined teachers has emerged as society has become more and more digitized, emphasizing the need for new methods when it comes to incorporating technology into education. Teacher educators have a dual obligation in this regard; they should not only be able to use technology for their own teaching but should also contribute to the growth of the technical digital competence of teachers. The primary goal of this study is to investigate the nature of cognitions of Malaysian teachers regarding (using) digital technology (DT) in English as a Second Language (ESL) literacy instruction. The research employs an exploratory case study approach, focusing on three teachers in Malaysia in a rural setting. The teachers were observed and interviewed, and the findings indicate that while these educators believe in DT's ability to enhance teaching, they are skeptical about the adoption of the use of technology. The results suggest that teaching experience generates knowledge of teaching strategies and shapes the teaching practices of teachers.

Keperluan untuk guru yang cenderung teknologi telah muncul ketika masyarakat menjadi semakin ‘digital’, menekankan perlunya kaedah baru ketika mengintegasikan teknologi ke dalam pendidikan. Pendidik guru mempunyai kewajiban tambahan dalam hal ini; mereka bukan sahaja perlu menggunakan teknologi untuk pengajaran mereka sendiri, tetapi juga harus menyumbang kepada pertumbuhan kecekapan digital teknikal guru pelatih. Matlamat utama kajian ini adalah untuk menyelidiki sifat kognisi guru Malaysia mengenai (dan penggunaan) teknologi digital (DT) dalam subjek Bahasa Inggeris sebagai Bahasa Kedua (ESL). Penyelidikan ini menggunakan pendekatan kajian kes eksploratori, dengan memberi tumpuan kepada tiga orang guru di Malaysia di beberapa sekolah luar bandar. Para guru dicerap dan diwawancara, dan penemuan menunjukkan bahawa walaupun para pendidik ini percaya pada kemampuan DT untuk meningkatkan pengajaran, namun mereka skeptikal tentang penerapan penggunaan teknologi. Hasilnya menunjukkan bahawa pengalaman mengajar menambahkan pengetahuan mengenai strategi pengajaran dan membentuk amalan pengajaran guru.
SaraGuVRA : PEMETAAN VISUAL REALITI MAYA 360° SECARA KREATIF MENERUSI TEKNOLOGI DIGITAL
Authors: AYOB ANUAR , Mohd Jainal Aslina 
Published: December 2021

Artikel ini khususnya mengetengahkan kebolehgunaan visual realiti maya 360 darjah (360°) yang dihasilkan melalui pemetaan visual secara kreatif menerusi teknologi digital, yang dapat memudahkan urusan navigasi atau merasai pengalaman penerokaan lokasi pelancongan secara maya oleh pengguna dalam kehidupan masa kini. Penyelidikan ini mengkaji keupayaan teknologi digital yang berupaya mengubah elemen fotografi, videografi dan grafik menjadi data serta visual secara kreatif melalui eksplorasi pemetaan lokasi yang dijalankan di Taman Negara Bako dan Teluk Melano, Sarawak. Teknologi digital melalui kaedah pemetaan yang menjana visual kreatif menerusi sentuhan elemen interaktiviti dalam memaparkan lokasi maya dapat mewujudkan gambaran kehadiran dan beradaan secara nyata pengguna di persekitaran yang belum dilawati secara fizikal. Hasil dari eksplorasi visual kreatif menggunakan pelantar teknologi digital, model percubaan pemetaan visual reality maya 360° dengan nama SaraGuVRA (Sarawak Guided Virtual Reality Assistant) telah diterjemahkan bagi dirujuk oleh penyelidik untuk tujuan navigasi reality maya secara digital pengguna dalam maklumat awal berkaitan dengan lokasi yang ingin dituju menerusi pemetaan visual reality maya 360° secara kreatif yang dapat digunakan untuk tujuan pelancongan oleh mereka jika hasil penyelidikan iaitu navigasi ini berjaya direalisasikan.
An Exploratory Analysis of the Role of Adipose Characteristics in Fulltime Wheelchair Users’ Pressure Injury History
Authors: Sonenblum Sharon Eve , Measel Megan , Sprigle Stephen H. , Greenhalgh John , Cathcart John McKay 
Published: December 2021

Aim:The goals of this study were 1) to identify the relationship between adipose (subcutaneous and intramuscular) characteristics and pressure injury (PrI) history in wheelchair users and 2) to identify subject characteristics, including biomechanical risk, that are related to adipose characteristics.Materials and Methods:The buttocks of 43 full-time wheelchair users with and without a history of pelvic PrIs were scanned in a seated posture in a FONAR UPRIGHT® MRI. Intramuscular adipose (the relative difference in intensity between adipose and gluteus maximus) and the subcutaneous adipose characteristics (the relative difference in intensity between subcutaneous adipose under and surrounding the ischium) were compared to PrI history and subject characteristics.Results:Participants with a history of PrIs had different subcutaneous fat (subQF) characteristics than participants without a history of PrIs. Specifically, they had significantly darker adipose under the ischium than surrounding the ischium (subQF effect size = 0.21) than participants without a history of PrIs (subQF effect size = 0.58). On the other hand, only when individuals with complete fat infiltration (n = 7) were excluded did individuals with PrI history have more fat infiltration than those without a PrI history. The presence of spasms (μ intramuscular adipose, 95% CI with spasms 0.642 [0.430, 0.855], without spasms 0.168 [−0.116, 0.452],p= 0.01) and fewer years using a wheelchair were associated with leaner muscle (Pearson Corr = −0.442,p= 0.003).Conclusion:The results of the study suggest the hypothesis that changes in adipose tissue under the ischial tuberosity (presenting as darker SubQF) are associated with increased biomechanical risk for pressure injury. Further investigation of this hypothesis, and the role of intramuscular fat infiltration in PrI development, may help our understanding of PrI etiology. It may also lead to clinically useful diagnostic techniques that can identify changes in adipose and biomechanical risk to inform early preventative interventions.
Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment
Authors: Wang Lipeng , Zhang Hao , Wang Sicheng , Chen Xiao , Su Jiacan 
Published: December 2021

Recognized for nearly 100 years, bone marrow adipocytes (BMAs) form bone marrow niches that contain hematopoietic and bone cells, the roles of which have long been underestimated. Distinct from canonical white, brown, and beige adipocytes, BMAs derived from bone marrow mesenchymal stromal cells possess unique characteristics and functions. Recent single-cell sequencing studies have revealed the differentiation pathway, and seminal works support the tenet that BMAs are critical regulators in hematopoiesis, osteogenesis, and osteoclastogenesis. In this review, we discuss the origin and differentiation of BMAs, as well as the roles of BMAs in hematopoiesis, osteogenesis, osteoclastogenesis, and immune regulation. Overall, BMAs represent a novel target for bone marrow-related diseases, including osteoporosis and leukemia.
Acorenone C: A New Spiro-Sesquiterpene from a Mangrove-Associated Fungus, Pseudofusicoccum sp. J003
Authors: Jia Shujie , Su Xiangdong , Yan Wensi , Wu Meifang , Wu Yichuang , Lu Jielang , He Xin , Ding Xin , Xue Yongbo 
Published: December 2021

Mangrove-derived endophytes are rich in bioactive secondary metabolites with a variety of biological activities. Recently, a fungus Pseudofusicoccum sp. J003 was first isolated by our research group from mangrove species Sonneratia apetala Buch.-Ham. The subsequent chemical investigation of the methanol extract of the culture broth of this strain has led to the isolation of a new sesquiterpenoid named acorenone C (1), two alkaloids (2–3), four phenolic compounds (4–7), and four steroid derivatives (8–11). The new structure of 1 was established by extensive spectroscopic analysis, including 1D, 2D NMR spectroscopy, and HRESIMS. Its absolute configuration was elucidated by experimental ECD and ECD calculation. The in vitro AChE inhibitory, anti-inflammatory, and cytotoxic activities of the selected compounds were evaluated. The results showed that compound 1 showed mild AChE inhibitory activity, with an inhibition rate of 23.34% at the concentration of 50 μM. Compound 9 exerted a significant inhibitory effect against nitric oxide (NO) production in LPS-stimulated RAW 264.7 mouse macrophages, with an inhibition rate of 72.89% at the concentration of 25 μM, better than that of positive control L-NMMA. Compound 9 also displayed obvious inhibition effects on the growth of two human tumor cell lines, HL-60 and SW480 (inhibition rates 98.68 ± 0.97% and 60.40 ± 4.51%, respectively). The antimicrobial activities of the compounds (1–11) against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa were also tested; however, none of them showed antimicrobial activities.
Cu-Based Conductive MOF Grown in situ on Cu Foam as a Highly Selective and Stable Non-Enzymatic Glucose Sensor
Authors: Hu Qin , Qin Jie , Wang Xiao-Feng , Ran Guang-Ying , Wang Qiang , Liu Guang-Xiang , Ma Jian-Ping , Ge Jing-Yuan , Wang Hai-Ying 
Published: December 2021

A non-enzymatic electrochemical sensor for glucose detection is executed by using a conductive metal–organic framework (MOF) Cu-MOF, which is built from the 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP) ligand and copper acetate by hydrothermal reaction. The Cu-MOF demonstrates superior electrocatalytic activity for glucose oxidation under alkaline pH conditions. As an excellent non-enzymatic sensor, the Cu-MOF grown on Cu foam (Cu-MOF/CF) displays an ultra-low detection limit of 0.076 μM through a wide concentration range (0.001–0.95 mM) and a strong sensitivity of 30,030 mA μM−1 cm−2. Overall, the Cu-MOF/CF exhibits a low detection limit, high selectivity, excellent stability, fast response time, and good practical application feasibility for glucose detection and can promote the development of MOF materials in the field of electrochemical sensors.
Quantum Dynamics of Rotational Transitions in CN (X2Σ+) by H+ Collisions
Authors: Anusuri Bhargava , Dhilip Kumar T. J. , Kumar Sanjay 
Published: December 2021

Collisional cross-sections of inelastic rotational excitations of CN in its ground electronic state (X2Σ+) by H+ scattering are studied by the exact quantum mechanical close-coupling (CC) method at very low collision energies (0–600 cm−1) relevant to interstellar atmospheres. Ab initio rigid rotor potential energy surface computed at MRCI/cc-pVTZ level of accuracy has been employed. Rate coefficients for the rotational excitations have also been calculated. The obtained results are compared with previous theoretical calculations and analyzed whether proton collisions could be significant sources for rotationally excited CN as a possible source for cosmic microwave background of about 3 K from the interstellar media.
Vaginal Microbiota, Genital Inflammation and Extracellular Matrix Remodelling Collagenase: MMP-9 in Pregnant Women With HIV, a Potential Preterm Birth Mechanism Warranting Further Exploration
Authors: Short Charlotte-Eve S. , Quinlan Rachael A. , Wang Xuan , Preda Veronica Georgiana , Smith Ann , Marchesi Julian R. , Lee Yooni S. , MacIntyre David A. , Bennett Phillip R. , Taylor Graham P. 
Published: December 2021

BackgroundPregnant women living with HIV infection (PWLWH) have elevated rates of preterm birth (PTB) in which HIV and cART are implicated. PWLWH also have a high prevalence of adverse vaginal microbiota, which associate with genital tract inflammation. The mechanism underlying PTB in PWLWH is unknown. We present the first data in PWLWH on genital-tract matrix-metalloproteinase-9(MMP-9), an important collagenase implicated in labour onset, and tissue inhibitor of metalloproteinases-1(TIMP-1) and explore correlations with local inflammation and vaginal bacteria.Material and MethodsCervical vaginal fluid (CVF) collected by a soft cup and high vaginal swabs (HVS) were obtained from PWLWH and HIV uninfected pregnant women (HUPW) at three antenatal time points. Maternal characteristics, combination antiretroviral therapy (cART) exposure, and pregnancy outcome were recorded. Concentrations of MMP-9, TIMP-1 and ten cytokines were measured by immunoassays. Vaginal microbiota composition was determined through 16S rRNA amplicon sequencing. MMP-9, TIMP-1 and cytokine concentrations were compared by HIV status, cART, and prematurity and in PWLWH correlations with polymorphonuclear leucocytes, cytokines and bacterial genera were explored.ResultsCVF was available for 50 PWLWH (108 samples) and 12 HUPW (20 samples) between gestation weeks 14-38. Thirty-six PWLWH conceived on cART and 14 initiated post-conception. There were five and one PTB outcomes in PWLWH and HUPW respectively. PWLWH had higher mean CVF concentrations of MMP-9 (p&lt;0.001) and TIMP-1 (p=0.035) in the second trimester compared with HUPW with a similar trend in the third trimester. PWLWH also had higher CVF values of cytokines: IL-1β, IL-8, IL-12 and TNF-α in both trimesters compared to HUPW (p ≤ 0.003). In PWLWH, MMP-9 positively correlated with TIMP-1 (r=0.31, p=0.002) and CVF polymorphonuclear leucocytes (r=0.57, p=0.02). Correlations were observed between MMP-9 and three cytokines: IL-1β (r=0.61), IL-8 (r=0.57) and TNF-α (r=0.64), p&lt;0.001, similarly for TIMP-1. Abundance of anaerobic pathobionts correlated with MMP-9: Gardnerella (r=0.44, p&lt;0.001), Atopobium (r=0.33, p=0.005), and Prevotella genera (r=0.39, p&lt;0.001). Conversely proportion of Lactobacillus genera negatively correlated with MMP-9 (rho=-0.46, p&lt;0.001). MMP-9/TIMP-1 ratio increased with gestational age at sampling in PWLWH, but this was no longer significant after adjusting for confounders and no difference by prematurity was observed in this sub-study.ConclusionsHere we show strong correlations of MMP-9 to genital tract inflammation and sub-optimal bacterial genera in PWLWH indicating the ascending genital tract infection pathway may be a contributory mechanism to the high risk of PTB.
Hsa_circ_0003204 Knockdown Weakens Ox-LDL-Induced Cell Injury by Regulating miR-188-3p/TRPC6 Axis in Human Carotid Artery Endothelial Cells and THP-1 Cells
Authors: Peng Wenjia , Li Shuai , Chen Shiyue , Yang Jiacheng , Sun Ze 
Published: December 2021

Background: Circular RNAs (circRNAs) are involved in atherosclerosis (AS) development. However, the function and mechanism of circRNA hsa_circ_0003204 (circ_0003204) in carotid artery AS remain unclear.Methods: Oxidized low-density lipoprotein (ox-LDL)-treated human carotid artery endothelial cells (HCtAECs) and THP-1 cells were used as cell models of carotid artery AS. Relative levels of circ_0003204, microRNA-188-3p (miR-188-3p), and transient receptor potential canonical channel 6 (TRPC6) were detected by quantitative reverse transcription–polymerase chain reaction or Western blotting. The targeting relationship between circ_0003204 or TRPC6 and miR-188-3p was assessed via dual-luciferase reporter analysis and RNA immunoprecipitation. Cell proliferation was assessed via 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay and 5-ethynyl-2′-deoxyuridine (EdU) assay. Cell apoptosis was analyzed via assessing cell caspase-3 activity, apoptosis, and apoptosis-related protein. Inflammatory response was analyzed via analysis of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α). Oxidative stress was assessed via determination of reactive oxygen species (ROS), malondialdehyde (MDA), and superoxide dismutase (SOD).Results: Circ_0003204 and TRPC6 levels were elevated, and miR-188-3p expression declined in ox-LDL-treated HCtAECs and THP-1 cells. Circ_0003204 could regulate TRPC6 expression via mediating miR-188-3p. Circ_0003204 silencing weakened ox-LDL-induced viability inhibition and apoptosis in HCtAECs, and inflammatory response and oxidative stress in THP-1 cells via regulating miR-188-3p. MiR-188-3p overexpression attenuated ox-LDL-induced injury in HCtAECs and THP-1 cells by targeting TRPC6.Conclusion: Circ_0003204 knockdown mitigated ox-LDL-induced injury in HCtAECs and THP-1 cells via regulating the miR-188-3p/TRPC6 axis, indicating that circ_0003204 might play an important role in carotid artery AS.
Cardiorespiratory Polygraphy for Detection of Obstructive Sleep Apnea in Patients With Atrial Fibrillation
Authors: Delesie Michiel , Knaepen Lieselotte , Verbraecken Johan , Weytjens Karolien , Dendale Paul , Heidbuchel Hein , Desteghe Lien 
Published: December 2021

Background: Obstructive sleep apnea (OSA) is a modifiable risk factor of atrial fibrillation (AF) but is underdiagnosed in these patients due to absence of good OSA screening pathways. Polysomnography (PSG) is the gold standard for diagnosing OSA but too resource-intensive as a screening tool. We explored whether cardiorespiratory polygraphy (PG) devices using an automated algorithm for Apnea-Hypopnea Index (AHI) determination can meet the requirements of a good screening tool in AF patients.Methods: This prospective study validated the performance of three PGs [ApneaLink Air (ALA), SOMNOtouch RESP (STR) and SpiderSAS (SpS)] in consecutive AF patients who were referred for PSG evaluation. Patients wore one of the three PGs simultaneously with PSG, and a different PG during each of three consecutive nights at home. Severity of OSA was classified according to the AHI during PSG (&lt;5 = no OSA, 5–14 = mild, 15–30 = moderate, &gt;30 = severe).Results: Of the 100 included AF patients, PSG diagnosed at least moderate in 69% and severe OSA in 33%. Successful PG execution at home was obtained in 79.1, 80.2 and 86.8% of patients with the ALA, STR and SpS, respectively. For the detection of clinically relevant OSA (AHI ≥ 15), an area under the curve of 0.802, 0.772 and 0.803 was calculated for the ALA, STR and SpS, respectively.Conclusions: This study indicates that home-worn PGs with an automated AHI algorithm can be used as OSA screening tools in AF patients. Based on an appropriate AHI cut-off value for each PG, the device can guide referral for definite PSG diagnosis.
Structured Reporting of Computed Tomography in the Staging of Neuroendocrine Neoplasms: A Delphi Consensus Proposal
Authors: Granata Vincenza , Coppola Francesca , Grassi Roberta , Fusco Roberta , Tafuto Salvatore , Izzo Francesco , Reginelli Alfonso , Maggialetti Nicola , Buccicardi Duccio , Frittoli Barbara , Rengo Marco , Bortolotto Chandra , Prost Roberto , Lacasella Giorgia Viola , Montella Marco , Ciaghi Eleonora , Bellifemine Francesco , De Muzio Federica , Danti Ginevra , Grazzini Giulia , De Filippo Massimo , Cappabianca Salvatore , Barresi Carmelo , Iafrate Franco , Stoppino Luca Pio , Laghi Andrea , Grassi Roberto , Brunese Luca , Neri Emanuele , Miele Vittorio , Faggioni Lorenzo 
Published: December 2021

BackgroundStructured reporting (SR) in radiology is becoming increasingly necessary and has been recognized recently by major scientific societies. This study aims to build structured CT-based reports in Neuroendocrine Neoplasms during the staging phase in order to improve communication between the radiologist and members of multidisciplinary teams.Materials and MethodsA panel of expert radiologists, members of the Italian Society of Medical and Interventional Radiology, was established. A Modified Delphi process was used to develop the SR and to assess a level of agreement for all report sections. Cronbach’s alpha (Cα) correlation coefficient was used to assess internal consistency for each section and to measure quality analysis according to the average inter-item correlation.ResultsThe final SR version was built by including n=16 items in the “Patient Clinical Data” section, n=13 items in the “Clinical Evaluation” section, n=8 items in the “Imaging Protocol” section, and n=17 items in the “Report” section. Overall, 54 items were included in the final version of the SR. Both in the first and second round, all sections received more than a good rating: a mean value of 4.7 and range of 4.2-5.0 in the first round and a mean value 4.9 and range of 4.9-5 in the second round. In the first round, the Cα correlation coefficient was a poor 0.57: the overall mean score of the experts and the sum of scores for the structured report were 4.7 (range 1-5) and 728 (mean value 52.00 and standard deviation 2.83), respectively. In the second round, the Cα correlation coefficient was a good 0.82: the overall mean score of the experts and the sum of scores for the structured report were 4.9 (range 4-5) and 760 (mean value 54.29 and standard deviation 1.64), respectively.ConclusionsThe present SR, based on a multi-round consensus-building Delphi exercise following in-depth discussion between expert radiologists in gastro-enteric and oncological imaging, derived from a multidisciplinary agreement between a radiologist, medical oncologist and surgeon in order to obtain the most appropriate communication tool for referring physicians.
Long-Term Physical Activity Participation and Subsequent Incident Type 2 Diabetes Mellitus: A Population-Based Cohort Study
Authors: Li Chenglong , Ma Yanjun , Hua Rong , Zheng Fanfan , Xie Wuxiang 
Published: December 2021

BackgroundUncertainty remains concerning association between long-term physical activity and incident type 2 diabetes mellitus (DM). We intended to evaluate physical activity participation over a 6-year span and assess association with subsequent 10-year incident DM risk, as well as examine mediation role by obesity.MethodsA total of 9757 community-dwelling adults aged ≥ 50 years in England were included in the population-based cohort. Physical activity participation, including trajectories and cumulative participation were assessed using weighted Z score over a 6-year span from wave 1 (2002–2003) to wave 4 (2008–2009). Incident DM recorded over a 10-year span from wave 4 (2008–2009) to wave 9 (2018–2019) was outcome.Results5 distinct activity trajectories were identified, including persistently low (N=3037, incident DM=282), initially low then improving (1868, 90), initially high then declining (325, 20), persistently moderate (2489, 170), and persistently high (2038, 108). Compared with persistently low, participants of initially low then improving, persistently moderate and high were associated with lower incident DM risk, with multivariable-adjusted hazard ratios (HR) of 0.41 (95% confidence interval [CI]: 0.32 to 0.53, P&lt;0.001), 0.70 (95% CI: 0.56 to 0.89, P=0.004) and 0.49 (95% CI: 0.37 to 0.65, P &lt;0.001), respectively. Elevated cumulative activity was also associated with lower DM risk, with each quintile increment in cumulative weighted Z score corresponding to HR of 0.76 (95% CI: 0.71 to 0.82, P &lt;0.001). Mediation analysis found that body mass index, waist circumference and change in body mass index mediate 10% (P &lt;0.001), 17% (P &lt;0.001) and 9% (P &lt;0.001) of the observed association between activity and incident DM, respectively.ConclusionsFor middle aged and older adults, both gradually improved and persistently active participation in physical activity were associated with subsequent lower risk of incident DM, with obesity playing a potential mediator. Strategies focusing on improving and maintaining active participation in physical activity might be beneficial from DM prevention perspective.