bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Related To Schizoprenia Patients’ Ability In Performing Self-Treatment
Authors: Dwi Jayanti Desak Made Ari , Arwidiana Dewa Putu 
Published: June 2021

Background: Schizophrenia is one of mental disorder occurring and raising number of problems. One of which is the ability in performing self-treatment. This phenomenon suggests that there be declination of motivation in performing self-treatment.
Methods: The research purposed to know the factors related to schizophrenia patient’s ability in performing self-treatment. This research used descriptive correlation with cross-sectional approach. The samples taking were done by random sampling with 155 persons with schizophrenia as samples. The bivariate examination used Spearmen test.
Results: The result of the research suggested that p value = 0,771; 0,959; 0,473; 0,500; 0,818; 0,837; 0,956 for each variable; sex, age, hallucination, delusion, violence behavior risk, the length of treatment, and the length of getting mental disorder with ability in performing self-treatment. It indicates that there is not any relationship between one variable with another. Meanwhile, variable in social isolation disturbance in body image and frequency related to how many times getting treatment with the ability in performing self-treatment. Each variable was found that p value were at 0,001; 0,001; 0,002 (p value <0, 0005).
Conclusion: Those values indicate that there is relation between one variable to another. Further nursing intervention is needed to improve the ability of schizophrenia patients to perform self-care
Anti-Mutant Efficacy of Combination Therapy with Doripenem and Levofloxacin: <i>In Vitro</i> Model Studies with <i>Pseudomonas Aeruginosa</i>
Authors: Golikova M. V. , Strukova E. N. , Alieva K. N. , Filimonova A. V. , Portnoy Yu. A. , Firsov A. A. 
Published: June 2021

Relevance. The tendency to a decrease in sensitivity of bacterial agents to old antibiotics, as well as the slowdown in creation of new medications, dictate the need to develop effective approaches to combat bacterial resistance.Aim. Evaluation of the applicability of a pharmacokinetically-based approach to predicting anti-mutant effectiveness of combined therapy with doripenem and levofloxacin against gram-negative bacteria Pseudomonas aeruginosa.Material and methods. A collection strain of Pseudomonas aeruginosa was used in the study. The values of MPC (mutant prevention concentration) of the combination of doripenem and levofloxacin were evaluated at a ratio of their concentrations equal to therapeutic ratios of the area under the pharmacokinetic curve in the in vitro dynamic model. 5-day treatments with clinical doses of doripenem and levofloxacin individually and in combination were simulated. Bacteria-containing medium was sampled during the experiments and plated on agar media containing 2MIC of each antibiotic.Results. The MPCs of doripenem and levofloxacin decreased 4 times when used in combination compared to MPC values when used separately. P.aeruginosa population was enriched with resistant mutants during monotherapy with each medication; the number of the bacteria did not decrease or even increased by the end of observation period. The use of doripenem/levofloxacin combination completely prevented development of resistance to both drugs in P.aeruginosa. The observed anti-mutant effect of antibiotic combination was consistent with higher (compared to monotherapy) values of the time during which the concentration of the antibiotic exceeded MPC (T>MPC).Conclusion. The anti-mutant effectiveness of combined therapy with doripenem and levofloxacin increased with the decrease in the values of MPC of antibiotics when used simultaneously, which consequently led to the increase in the values of T>MPC. Obtained results confirm the applicability of a pharmacokinetically-based approach to the estimation of MPC of combined antibiotics for predicting anti-mutant effectiveness of combination therapy in the treatment of infections caused by gram-negative bacteria.
Eradication, Strain Preservation, Strain Change — Outcomes of <i>Helicobacter pylori</i> Therapy
Authors: Golubkina E. V. , Sorokin V. M. , Levitan B. N. , Umerova A. R. , Kamneva N. V. 
Published: June 2021

Relevance. If we reduce the treatment exclusively to the eradication of Helicobacter pylori (Hp), the question of monitoring the results of anti-Hp therapy is controversial, given the widely known data on the detection of Hp, including virulent strains of Hp, in most healthy individuals.The aim of the study: to track the dynamics of stomach colonization with various Hp strains in patients with gastric ulcer and duodenal ulcer (PUD) immediately after the use of standard three-component anti-Hp therapy (AHT) and 1.5–2 months after AHT.Methods. Genotyping of Hp strains was carried out by the VNTR method together with the determination of the cagA gene.Results. Assessment of the results of AHT in the form of «eradication of Hp — re-detection of Hp» (i. e., without taking the determination of Hp strains into account) showed less reliability in the differences than the «eradication — preservation of the strain or change of the strain» score in patients with PUD; in addition, the differences between the initial bacteriological picture and that observed immediately after AHT were on the verge of reliability, while the differences between the initial bacteriological picture and that observed after 1.5–2 months had a high degree of reliability. The number of eradications increased (eradication achieved immediately after AHT was not preserved, except for one) and the number of cagA-containing strains decreased (due to new eradication detected at late follow-up periods and due to a change in strains) in long-term follow-up in patients with PUD.Conclusion. Since all patients with PUD achieved clinical remission, which lasted for the next 1.5–2 months, the success of AHT should not be unambiguously associated with the eradication of Hp; the restoration of the organism's colonization resistance to Hp after a course of therapy is more likely.
Study of Cases of Bacteremia with Gram-Negative Pathogens with Multiple and Extreme Antibiotic Resistance in Real Clinical Practice
Authors: Zhuravleva M. V. , Rodionov B. A. , Lysenko M. A. , Yakovlev S. V. , Andreev S. S. , Ilyukhina N. N. , Prokofiev A. B. 
Published: June 2021

Aim:To study cases of bacteremia caused by multidrug-resistant (MDR) and extremely-resistant (XDR) gram-negative bacteria in the departments of a multidisciplinary hospital.Material and Methods.Since 2017, a retrospective epidemiological study has been conducted to investigate cases of infections with bacteremia caused using gram-negative bacteria with multiple or extreme antibiotic resistance. The pathogens were identified using the MALDI-TOF MS method, the sensitivity to antibacterial drugs was determined using the automatic Phoenix system, the beta-lactamase genes were detected using real-time PCR on a GeneXpert analyzer.Results.In 2017, bacteremia caused by MDR and XDR pathogens was detected in 42 and 76 patients, in 2018 — in 57 and 81 patients, in 2019 — in 65 and 111 patients, respectively. During three years of observation, the most frequent XDR microorganisms were, in descending order,Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa. In 2019, among 11K.pneumoniaestrains, class D carbapenemase (OXA-48) was detected in 5 cases (45.5%), 3 strains produced NDM metallo-carbapenemase, and 3 strains had a combination of NDM and OXA-48 enzymes. Infections caused by MDR and XDR pathogens were characterized by high mortality. Thus, the relative risk of death in patients with XDR infection was 1.33 times higher than in patients from the MDR group (95% CI 1.04-1.69, P<0.05) in 2019. The duration of hospital stay also increased: in the XDR group — up to 29.5 days, in the MDR group – up to 16.4 days, with an average length of hospitalization of 6.0 bed-days in 2019.Conclusions.K.pneumoniaeandA.baumanniiwith extreme antibiotic resistance are the main causative agents of severe late nosocomial infections in immunosuppressed patients. Nosocomial infections with bacteremia caused by gram-negative bacteria with the XDR phenotype and resistant to carbapenems are characterized by a high mortality rate (from 72 to 80%), and increase the duration of hospitalization by more than 4 times.
Possibilities of Hyperinflammation Correction in COVID-19
Authors: Simutis I. S. , Boyarinov G. A. , Yuriev M. Yu. , Petrovsky D. S. , Kovalenko A. L. , Parfenov S. A. 
Published: June 2021

Objective. To evaluate the effect of sodium meglumine succinate on the severity of the systemic inflammatory response syndrome when used in complex therapy in patients with severe COVID-19.Material and Methods. The clinical and laboratory data of 12 patients with the diagnosis «Novel coronavirus infection COVID-19 complicated by community-acquired bilateral polysegmental interstitial pneumonia» were analyzed. All patients underwent intensive therapy with a limited volume of water load in the intensive care unit in accordance with the recommendations of the Ministry of Health of the Russian Federation. Seven patients (observation group) received a polyelectrolyte solution containing meglumine sodium succinate (Reamberin) as part of the therapy at a daily dose of 5 ml/kg during the entire period of stay in the ICU (3–10 days). The control group included 5 patients who received a similar volume of a conventional polyelectrolyte solution containing no metabolically active substrates. The study was pilot in nature due to the small number of patients. The laboratory parameters of arterial and venous blood were measured at the following stages: 1) upon admission to the ICU; 2) 2–4 hours after the completion of Reamberin infusion; 3) 8–12 hours after drug administration; 4) 24 hours after the start of intensive care. Mortality rate and the incidence of thrombotic complications in the groups were assessed on the 28th day of observation. The presence of the therapeutic intervention effect was established using multivariate analysis of variance (MANOVA).Results. A positive effect of the study drug on the severity of systemic inflammatory response syndrome (SIRS) against the background of ongoing etiotropic therapy was noted. Efficiency criteria were the correction of hyperfibrinogenemia, normalization of the platelet count, decrease in the level of C-reactive protein, ferritin, and leukocytosis. A significant decrease in the frequency of thromboembolic events was observed within 28 days of treatment, as well as a reduction in the length of time the patients spent in the ICU.Conclusion. Based on the results of the pilot study, it can be assumed that the antihypoxic and antiradical effects of the drug contribute to the reduction of pulmonary and systemic endotheliitis, which is characteristic of severe forms of the disease and, as a result, inhibits the development of the systemic inflammatory response syndrome. The data obtained can serve as a basis for further in-depth studies.
Effectiveness of Core Stability Exercise and Proprioception Exercise on Balance in Subjects with Diabetic Neuropathy- A Randomized Controlled Trial
Authors: Pavana  , Premrajan Nair Anjali 
Published: June 2021

Background and Objectives: Long standing Diabetes Mellitus leads to Diabetic Peripheral Neuropathyin the subjects which alter their daily activities performed. As physical activities are the key elements toprevent the further progress of Diabetes Mellitus. The neuropathy also affects the postural stability leadingto impaired balance and risk of falls in the subjects. The integrated activity of the motor and the sensorysystems play an important role in maintain the postural stability which depends upon the strength of thecore muscles and proper integrated activity of the proprioceptors of the lower limb. The prevalence of theDiabetic Peripheral neuropathy in India is around 10.5% to 32.2%. The Toronto Clinical scoring System isused as a marker to assess the level of neuropathy which has a relation on the stability. Thus, the aim of thestudy is to find the effectiveness of proprioception exercise or core stability exercise on balance in DiabeticPeripheral Neuropathy subjects.Objectives: To assess the effectiveness of core stability exercise on balance in Diabetic Neuropathysubjects.To assess the effectiveness of proprioception exercise on balance in Diabetic Neuropathy subjects.To compare the effectiveness of core stability exercise and proprioceptive exercise on balance in DiabeticNeuropathy subjects.Design: Comparative Randomized Parallel Open Label Study
Methods: Eighty subjects between the age 40-60 years were recruited for the study. Written informed consentand institutional ethical clearance was obtained. Demographic data were obtained and subjects were assignedto one of two groups: Group A: experimental group given Proprioception exercise (n=40) and Group B:control group given Core Stability exercise (n=40). The therapy was given for six weeks with three days in aweek and was measured with Berg Balance Scale as an outcome measure at the end of the 6 week protocol.Results: Both the groups showed improvement in the balance according to the Berg Balance Scale. Themean ± SD of pre and post Berg Balance Scale of GROUP A was 37.18 ± 4.81 and 39.41 ± 4.95 respectivelyand that of GROUP B was 36.95 ± 4.27 and 38.55 ± 4.29 respectively. Conclusion: The results showed asignificant improvement within Group A and Group B (P<0.001) but there is no significant improvement between both the groups (P>0.05). Thus thestudy concluded that proprioception exercise and core stability exercise are worthwhile in improving the balance in subjects with diabeticperipheral neuropathy.
Prevalencia y patrones de resistencia adquirida a antirretrovirales en menores de 18 años en el Hospital de Especialidades Pediátricas “Omar Torrijos Herrera”
Authors: Luciani Kathia , Compacnucci Alexandra 
Published: June 2021

Introducción: La resistencia a antirretrovirales compromete la efectividad del tratamiento de pacientes con infección por VIH, llevando a falla virológica e inmunológica, deterioro clínico y comprometiendo tratamientos futuros. Los niños y adolescentes tienen mayor riesgo de desarrollo de resistencia asociados a terapias prolongadas, mala adherencia y limitadas opciones terapéuticas. Se desconoce la prevalencia y patrones de resistencia adquirida en población pediátrica panameña.
Objetivos: Conocer la prevalencia y describir los patrones de resistencia adquirida en población pediátrica infectada con falla virológica en el período 2009-2019
Material y Método: Estudio descriptivo. Se incluyeron sujetos menores de 18 años de edad, con al menos un año de tratamiento, en falla virológica y que contaban con una prueba de genotipaje. Se realizó revisión de los expedientes clínicos para la obtención de los datos. Se describen las características demográficas, historial de tratamiento, resistencia a familias de antirretrovirales y mutaciones específicas
Resultados y conclusiones: 13 pacientes fueron incluidos en el estudio de un total de 72 pacientes con infección de VIH atendidos en el período de estudio, para una prevalencia de resistencia del 18% de sujetos en terapia con resistencia. Se encontró 92% de resistencia a Inhibidores de la transcriptasa reversa análogo de nucleósidos, 61.5% a inhibidores de la transcriptasa reversa no análogos de nucleósidos y 23% de resistencia a Inhibidores de proteasa, las mutaciones M184V y K103N fueron las más frecuentes. Se requiere mantener la vigilancia de resistencia en niños con el fin de ajustar las recomendaciones de tratamiento.
Las víctimas indirectas de la pandemia
Authors: Vargas Pedro Ernesto 
Published: June 2021

A 15 meses de la pandemia, todavía no conocemos los resultados del cierre de los servicios de salud ni las consecuencias de los manejos de muchas manos en ese plato. Nos preocupa, con razón, la alarmante serie de consecuencias negativas sobre la economía y sobre la educación, pero, en la marcha forzada, la pandemia desnudó las serias y crónicas falencias éticas del sistema de salud nacional
Living with Quality: Strategies for Transferring Social Housing Development to After-war Syria
Authors: Kalfaoğlu Hatipoğlu Hatice 
Published: June 2021

Obtaining a home in Syria has been an equivalent to a strategic goal around which the life of the Syrian citizen revolves. Housing was one of the problematic crises before the war, which accelerated due to the war. Moreover, this turned into a humanitarian disaster, and the situation has become more urgent and requires immediate treatment. The solution of this demolition is not limited to an easy rebuilding and needs a more sustainable and qualified policy in order to prevent to turn back to the existing crisis before the war. This paper focuses on finding an appropriate strategy to respond to the housing crisis in Syria in the light of successful implementations of social housing. In order to achieve that, after a literature review of the general context of social housing, the Singapore social housing experience has been analyzed. Considering the housing problems and implementations in Syria (before and after the war) in a comparative evaluation with the Singapore experience, some strategies have been suggested, along with discussing the transfer of this experience to the Syrian context. A list of recommendations for developing a social housing strategy based on a clear legal framework also provides a base for social housing.
Predicting the Spectrum of UGC 2885, Rubin’s Galaxy with Machine Learning
Authors: Holwerda Benne W. , Wu John F. , Keel William C. , Young Jason , Mullins Ren , Hinz Joannah , Ford K. E. Saavik , Barmby Pauline , Chandar Rupali , Bailin Jeremy , Peek Josh , Pickering Tim , Böker Torsten 
Published: June 2021

Abstract
Wu & Peek predict SDSS-quality spectra based on Pan-STARRS broadband grizy images using machine learning (ML). In this article, we test their prediction for a unique object, UGC 2885 (“Rubin’s galaxy”), the largest and most massive, isolated disk galaxy in the local universe (D < 100 Mpc). After obtaining the ML predicted spectrum, we compare it to all existing spectroscopic information that is comparable to an SDSS spectrum of the central region: two archival spectra, one extracted from the VIRUS-P observations of this galaxy, and a new, targeted MMT/Binospec observation. Agreement is qualitatively good, though the ML prediction prefers line ratios slightly more toward those of an active galactic nucleus (AGN), compared to archival and VIRUS-P observed values. The MMT/Binospec nuclear spectrum unequivocally shows strong emission lines except Hβ, the ratios of which are consistent with AGN activity. The ML approach to galaxy spectra may be a viable way to identify AGN supplementing NIR colors. How such a massive disk galaxy (M* = 1011
M
⊙), which uncharacteristically shows no sign of interaction or mergers, manages to fuel its central AGN remains to be investigated.
NOEMA High-fidelity Imaging of the Molecular Gas in and around M82
Authors: Krieger Nico , Walter Fabian , Bolatto Alberto D. , Guillard Pierre , Lehnert Matthew , Leroy Adam K. , Pety Jérôme , Emig Kimberly L. , Levy Rebecca C. , Krips Melanie , Rix Hans-Walter , Salak Dragan , Weiss Axel , Veilleux Sylvain 
Published: June 2021

Abstract
We present a 154 pointing IRAM NOEMA mosaic of the CO(1–0) line emission in and around the nearby starburst galaxy M82. The observations, complemented by zero-spacing observations, reach a spatial resolution of ∼30 pc (∼1.″9) at 5.0 km s−1 spectral resolution, sufficient to resolve the molecular gas in the central starburst disk, the outflow, and the tidal streamers. The resulting moment and peak brightness maps show a striking amount of structure. Using a clump decomposition algorithm, we analyze the physical properties (e.g., radii R, line widths σ, and masses M) of ∼2000 molecular clouds. To first order, the clouds’ properties are very similar, irrespective of their environment. This also holds for the size–line width relations of the clouds. The distribution of clouds in the σ
2/R versus column density Σ space suggests that external pressure does not play a significant role in setting their physical parameters in the outflow and streamers. We find that the clouds in the streamers stay approximately constant in size (R ∼ 50 pc) and mass (M ∼ 105
M
⊙) and do not vary with their projected distance from M82's center. The clouds in the outflow, on the other hand, appear to decrease in size and mass with distance toward the southern outflow. The reduction in the molecular gas luminosity could be indicative of cloud evaporation of embedded clouds in the hot outflow.
Clinical Outcomes After Phacoemulsification With Implantation of Trifocal and Toric Trifocal Intraocular Lenses
Authors: Eldanasoury Alaa , Tolees Sherif , Bains Harkaran S. 
Published: June 2021

PURPOSE:
To evaluate the visual and refractive outcomes, visual quality, patient satisfaction, and spectacle independence after phacoemulsification with bilateral implantation of a diffractive trifocal intraocular lens (IOL).

METHODS:

The study sample comprised 36 consecutive patients (72 eyes). Twenty-three (64%) patients underwent refractive lens exchange and 13 (36%) underwent cataract surgery. Exclusion criteria included previous ocular surgery, corneal higher order aberrations of greater than 0.4 µm, angle kappa of greater than 0.6 mm, and corneal astigmatism of greater than 5.00 diopters (D). All eyes were targeted for emmetropia. A toric IOL was used in 35 (48.6%%) eyes with corneal astigmatism of greater than 1.00 D. Uncorrected distance visual acuity (UDVA) and distance-corrected visual acuity were measured at 4 m and 80 and 40 cm. Patients underwent routine ophthalmic examination for 6 months postoperatively. Patient satisfaction was assessed with a subjective questionnaire at 6 months postoperatively. A
P
value of less than .05 was statistically significant.

RESULTS:

At 6 months postoperatively, the mean manifest refractive spherical equivalent was −0.01 ± 0.51 D. Binocular UDVA at 4 m and 80 and 40 cm was −0.02 ± 0.10, −0.07 ± 0.11, and 0.08 ± 0.10 logMAR, respectively. Binocular defocus curves presented two peaks of −0.07 and −0.02 logMAR for 0.00 and −2.00 D defocus, respectively. The Objective Scatter Index score decreased significantly in the cataract group and increased significantly in the refractive lens exchange group (
P
< .05, both cases). All patients were satisfied or very satisfied with the postoperative outcome.

CONCLUSIONS:
Bilateral implantation of a diffractive trifocal IOL resulted in good visual performance at all distances with high patient satisfaction and spectacle independence at 6 months postoperatively.

[
J Refract Surg
. 2021;37(6):372–379.]
Robert Owen, James Buchanan et l’Infant School de New Lanark
Authors: Vergnon Marie 
Published: June 2021

L’histoire de la prise en charge de la petite enfance fait une place importante à l’Infant School de New Lanark et à son fondateur, le réformateur écossais Robert Owen. Si la paternité de cette structure lui est communément attribuée, elle lui est cependant disputée par l’un de ses anciens enseignants dénommé James Buchanan. Quelle fut la part de chacun de ces deux hommes dans la création de cette structure originale ? Buchanan fut-il plus que le premier maître de l’Infant School ? C’est le plus souvent à travers les écrits d’Owen que nous connaissons cette expérience éducative. Ce sont ces textes qui constituent notre mémoire de la genèse de cette école des petits et nous livrent de rares éléments sur la pédagogie qui y était en usage. D’autres ressources permettent-elles d’éclairer les rôles respectifs des premiers acteurs de l’Infant School et de préciser les modalités du fonctionnement de l’établissement ? C’est à ces questions entourant l’origine d’un des premiers établissements de prise en charge collective de la petite enfance que cette recherche s’efforce d’apporter des éléments de réponse.