bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ketika Demokrasi Menjadi Ancaman?: Kasus Jerinx dan Refleksi Kritis Bagi Pelaksanaan Demokrasi di Indonesia
Authors: Abdulbari Fatih 
Published: December 2021

The most important and fundamental value in democracy is freedom of expression. This freedom is considered a part of human rights and is the most important feature of democracy. In the times, on the one hand, the media to speak out is increasingly numerous and varied, but on the other hand there is a dilemma where this freedom is actually used to sow and spread false information or conspiracy theories without evidence. In addition, the concept of freedom of opinion has not developed much following the latest developments, so this concept is increasingly abstract because there are no clear boundaries for freedom of expression. In Indonesia, the emergence of the Law on Information and Electronic Transactions (UU ITE) is actually used as a threat to criminalize individuals whose opinions are considered to be disturbing and attack others. The Jerinx case is a very interesting case study of how freedom of opinion has actually created a counterfactual narrative. He was convicted in 2020 for making hate speech on his social media accounts. The ITE Law which allows arrests for expressing opinions is problematic because it clearly contradicts the main principle of democracy, namely freedom of expression. This research will critically examine the Jerinx case from the perspective of democratic values to see and analyze how the right to speak and have an opinion in Indonesia. The extent to which freedom of opinion is actually facilitated is considered not to violate the rights of others, and the extent to which the democratic climate has a place in Indonesia.
The Meaning of Carnival Expel Epidemic Covid-19: Case Study Community Kelenteng Hian Thian Sian Tee and Hok Tek Bio in Welahan Jepara Central Java
Authors: Rosyid Mohammad 
Published: December 2021

This paper is based on writings that are description Khonghucu people in Kelenteng Hian Thian Sian Tee (Dewa Langit) and Hok Tek Bio (Dewa Bumi) at Covid-19 era in Welahan, Jepara City, Central Java. This research based on interview and participative, observation, and literature by approach description analysis. Result, effort people Khonghucu pandemic covid-19 era heirloom carnival purpose expel the plague (pagebluk covid-19) to be comfortable safe sosial at local and national. Carnival every Saturday night until April-November 2020 and every two weeks until Desember 2020 until now. Carnival by surround the Tionghoa village and Kelenteng so far 2 kilometers. Start and finish carnival in Kelenteng Hian Thian Siang Tee Gang Pinggir Pasar No.4. This kelenteng exist 5 kimsin (Kong Co Hiang Thian Siang Tee/Patung Dewa), referensi 120 medical prescription China vertion, a sword (pedang Tiongkok), bamboo fortune telling (ciamsi) by 49 poem, Po Kiam Hip lauw (ashtray, tempat abu), a volume of medical books (tjioe hwat). The meaning ornaments for carnival black flag, sword, rupang dewa, incense (dupa), and hio.
Tradisi Jimpitan Alternatif Pemulihan Ekonomi Nasional Akibat Pandemi Covid-19 Melalui UMKM Berbasis Kearifan Lokal
Authors: Hidayat Taufik , Ati Basdi , Hadiwasono Kodar 
Published: December 2021

Pandemi Covid-19 telah menimbulkan setidaknya 3 (tiga) dampak negatif bagi perekonomian Indonesia, di antaranya yaitu: (1) peningkatan angka kemiskinan, (2) peningkatan angka pengangguran, serta (3) melemahnya pelaku usaha. Pemerintah Republik Indonesia telah melakukan lima upaya untuk mengembalikan pertumbuhan ekonomi nasional. Dalam rangka membantu percepatan pemulihan ekonomi nasional, selain upaya - upaya yang dilakukan oleh pemerintah, masyarakat dapat berperan dengan berbasis kearifan lokal. Salah satu peran serta masyarakat berbasis kearifan lokal tersebut adalah “Tradisi Jimpitan”. Permasalahan dalam penelitian ini adalah: bagaimana mekanisme tradisi Jimpitan sebagai alternatif pemulihan ekonomi nasional akibat pandemi Covid-19? Penelitian ini menggunakan pendekatan kualitatif deskriptif, yaitu suatu pendekatan yang bertujuan untuk mendeskripsikan atau menggambarkan suatu fenomena atau kejadian dengan apa adanya. Dengan pemilihan rancangan deskriptif kualitatif, dilakukan pendekatan terhadap obyek penelitian dengan menggali informasi sesuai dengan persepsi peneliti. Setelah dilakukan penelitian dapat disimpulkan bahwa tradisi Jimpitan dapat diajukan sebagai salah satu solusi pemulihan ekonomi nasional melalui penguatan UMKM yang nantinya dapat mengurangi angka kemiskinan, mengurangi angka pengangguran dan menguatkan pelaku usaha.
Impact Assessment of Driver Distraction by Cellphone on Start-up Lost-time and Average Saturation Headway at Signalized Intersections Based on Vehicle Position in the Queue
Authors: Alshabibi Nawaf 
Published: December 2021

Cellphone usage has a significant impact on signalized intersections' capacity and level of service. This study investigated the impact of cellphone usage on signalized intersection capacity and level of service in Dammam Metropolitan Area, Saudi Arabia. The data included 183 useful cycles and 2407 start-up lost time and average saturation headway values at cycles with cellphone usage and cycles without cellphone usage at 24 signalized intersections. The main hypothesis of the study is that cellphone usage increases the start-up lost time at signalized intersection capacity. The secondary hypothesis is that cellphone usage increases the average saturation headway at signalized intersections. Normal distribution and z-test were conducted to assess whether there is a significant increase in average saturation headway and start-up lost time. The study found a significant increase in start-up lost time of about 0.7 seconds but found no significant increase in average saturation headway due to cellphone usage. Also, start-up lost time increases as vehicles of cellphone users get closer to the stop line of the signalized intersections. Thus, cellphone usage decreases the progression of 13 vehicles per hour due to a reduction in effective green time, increases total delay, and deteriorates the level of service. The study can assist transportation and traffic officials to optimize signal operation to mitigate the impact of cellphone usage and improve urban transportation.
van der Corput inequality for real line and Wiener-Wintner theorem for amenable groups
Authors: El Houcein El Abdalaoui 
Published: December 2021

We extend the classical van der Corput inequality to the real line. As a consequence, we obtain a simple proof of the Wiener-Wintner theorem for the RR-action which assert that for any family of maps (Tt)t∈R(Tt)t∈R acting on
the Lebesgue measure space (Ω,A,μ)(Ω,A,μ), where μμ is a probability measure and for any t∈Rt∈R, TtTt is measure-preserving transformation on measure space (Ω,A,μ)(Ω,A,μ) with
Tt∘Ts=Tt+sTt∘Ts=Tt+s, for any t,s∈Rt,s∈R. Then, for any
f∈L1(μ)f∈L1(μ), there is a single null set off which $\displaystyle \lim_{T \rightarrow +\infty} \frac{1}{T}\int_{0}^{T} f(T_t\omega) e^{2 i \pi \theta t} dt$limT→+∞1T∫0Tf(Ttω)e2iπθtdt
exists for all θ∈θ∈\RRR. We further present the joining proof of the amenable group version of Wiener-Wintner theorem due to Ornstein and Weiss.
American Cancer Society's report on the status of cancer disparities in the United States, 2021
Authors: Islami Farhad , Guerra Carmen E. , Minihan Adair , Yabroff K. Robin , Fedewa Stacey A. , Sloan Kirsten , Wiedt Tracy L. , Thomson Blake , Siegel Rebecca L. , Nargis Nigar , Winn Robert A. , Lacasse Lisa , Makaroff Laura , Daniels Elvan C. , Patel Alpa V. , Cance William G. , Jemal Ahmedin 
Published: December 2021

AbstractIn this report, the authors provide comprehensive and up‐to‐date US data on disparities in cancer occurrence, major risk factors, and access to and utilization of preventive measures and screening by sociodemographic characteristics. They also review programs and resources that have reduced cancer disparities and provide policy recommendations to further mitigate these inequalities. The overall cancer death rate is 19% higher among Black males than among White males. Black females also have a 12% higher overall cancer death rate than their White counterparts despite having an 8% lower incidence rate. There are also substantial variations in death rates for specific cancer types and in stage at diagnosis, survival, exposure to risk factors, and receipt of preventive measures and screening by race/ethnicity, socioeconomic status, and geographic location. For example, kidney cancer death rates by sex among American Indian/Alaska Native people are ≥64% higher than the corresponding rates in each of the other racial/ethnic groups, and the 5‐year relative survival for all cancers combined is 14% lower among residents of poorer counties than among residents of more affluent counties. Broad and equitable implementation of evidence‐based interventions, such as increasing health insurance coverage through Medicaid expansion or other initiatives, could substantially reduce cancer disparities. However, progress will require not only equitable local, state, and federal policies but also broad interdisciplinary engagement to elevate and address fundamental social inequities and longstanding systemic racism.
EVALUASI PELAKSANAAN E-TENDERING PADA UNIT LAYANAN PENGADAAN DAERAH KEMENTERIAN KEUANGAN PROVINSI SULAWESI SELATAN
Authors: Salupra Yohanis 
Published: December 2021

Pelaksanaan pengadaan barang/jasa pemerintah melalui e-tendering di Indonesia masih mengalami beberapa masalah. Seperti halnya pelaksanaan e-tendering pada Unit Layanan Pengadaan Daerah Kementerian Keuangan Provinsi Sulawesi Selatan yang mengalami tender gagal. Pada tahun 2016, jumlah tender gagal sebanyak enam paket tender gagal sebesar Rp4.695.581.000,00. Kemudian pada tahun 2017, jumlah paket tender gagal sebanyak empat paket sebesar Rp36.531.445.000,00. Pada tahun 2018, sebanyak empat paket mengalami tender gagal senilai Rp23.407.124.000,00. Sampai Agustus 2019, tender gagal terjadi sebanyak dua paket dengan nilai Rp2.061.932.000,00. Selain itu, masih terdapat adanya persekongkolan penyedia dalam mengikuti tender. Penelitian ini bertujuan untuk melakukan evaluasi terhadap Pelaksanaan E-Tendering Pada Unit Layanan Pengadaan Daerah Kementerian Keuangan Provinsi Sulawesi Selatan dengan menggunakan pendekatan deskriptif kualitatif melalui wawancara, observasi, dan studi dokumentasi. Hasil penelitian menunjukkan bahwa terdapat keterlambatan penyelesaian tender, dan penerapan reverse auction yang belum sesuai dengan ketentuan. Kecukupan biaya dan hasil dalam pelaksanaan e-tendering telah terpenuhi dan juga terjadi perataan distribusi kegiatan dan manfaat bagi setiap pihak yang terlibat secara langsung dalam proses e-tendering. Kepuasan para pihak dalam melaksanakan e-tendering adalah kemudahan akses sistem, persaingan dan prosesnya yang terbuka, dan mampu mengurangi beban kerja. Maintenance jaringan yang mengganggu jadwal tender, kewajaran nilai honorarium Pokja ULPD, dan proses pemberian penjelasan belum sesuai dengan ketentuan. Pelaksanaan e-tendering pada Unit Layanan Pengadaan Daerah Kementerian Keuangan Provinsi Sulawesi Selatan telah dilaksanakan cukup baik tetapi masih terdapat beberapa hal yang perlu dibenahi, diantaranya status ad hoc Pokja ULPD, kompetensi para pihak, koordinasi antara PPK dengan Pokja ULPD, maintenance jaringan, kewajaran nilai honorarium Pokja ULPD, dan pelaksanaan tahapan pemberian penjelasan.
Analisis Perubahan Lahan Sawah Areal Pengairan Bendungan Dikaitkan Dengan Ketahanan Pangan
Authors: Nursajidah Nursajidah , Golok Jaya La Ode Muh. , Iradat Salihin Laode Muh. 
Published: December 2021

Abstrak: Konversi lahan pertanian menimbulkan dampak negatif terhadap pembangunan pertanian, sehingga menurunkan kapasitas produksi pertanian, rusaknya sistem pengairan dan hilangnya investasi yang telah ditanamkan dalam membangun jaringan irigasi dan pembuatan teras pematang sawah. Penelitian ini bertujuan untuk: (1) mengetahui perubahan lahan sawah menggunakan Citra Landsat multitemporal; (2) mengetahui pengaruh perubahan lahan sawah areal Bendungan Wawotobi terhadap pemenuhan kebutuhan dan ketahanan pangan. Metode analisis data dalam penelitian ini adalah: (1) analisis penggunaan lahan dengan metode berbasis objek; (2) analisis estimasi produksi dan kebutuhan beras. Hasil penelitian ini antara lain: (1) perubahan luas lahan sawah tahun 2009 seluas 4.291,6 ha dan meningkat menjadi seluas 7.162,67 ha pada tahun 2018; (2) analisis estimasi produksi tanaman padi pada empat Kecamatan di Kabupaten Konawe dalam areal Pengairan Bendungan Wawotobi, yaitu Kecamatan Pondidaha didapat sebesar 8.138,99 ton dan kebutuhan beras 837,9 ton/tahun dengan jumlah penduduk 11.970 jiwa, Kecamatan Wonggeduku sebesar 48.416,13 ton dan kebutuhan beras 952,14 ton/tahun dengan jumlah penduduk 13.602 jiwa, Kecamatan Wawotobi sebesar 9.801,20 ton dan kebutuhan beras 1.619,8 ton/tahun dengan jumlah penduduk 23.140 jiwa, dan Kecamatan Unaaha sebesar 1.984,27 ton dan kebutuhan beras 1.821,89 ton/tahun dengan jumlah penduduk 26.027 jiwa.Kata Kunci: Sawah, Perubahan Lahan Sawah, Ketahanan Pangan
Low Dose Chronic Angiotensin II Induces Selective Senescence of Kidney Endothelial Cells
Authors: Khan Irfan , Schmidt Marcel O. , Kallakury Bhaskar , Jain Sidharth , Mehdikhani Shaunt , Levi Moshe , Mendonca Margarida , Welch William , Riegel Anna T. , Wilcox Christopher S. , Wellstein Anton 
Published: December 2021

Angiotensin II can cause oxidative stress and increased blood pressure that result in long term cardiovascular pathologies. Here we evaluated the contribution of cellular senescence to the effect of chronic exposure to low dose angiotensin II in a model that mimics long term tissue damage. We utilized the INK-ATTAC (p16Ink4a–Apoptosis Through Targeted Activation of Caspase 8) transgenic mouse model that allows for conditional elimination of p16Ink4a -dependent senescent cells by administration of AP20187. Angiotensin II treatment for 3 weeks induced ATTAC transgene expression in kidneys but not in lung, spleen and brain tissues. In the kidneys increased expression of ATM, p15 and p21 matched with angiotensin II induction of senescence-associated secretory phenotype genes MMP3, FGF2, IGFBP2, and tPA. Senescent cells in the kidneys were identified as endothelial cells by detection of GFP expressed from the ATTAC transgene and increased expression of angiopoietin 2 and von Willebrand Factor, indicative of endothelial cell damage. Furthermore, angiotensin II induced expression of the inflammation-related glycoprotein versican and immune cell recruitment to the kidneys. AP20187-mediated elimination of p16-dependent senescent cells prevented physiologic, cellular and molecular responses to angiotensin II and provides mechanistic evidence of cellular senescence as a driver of angiotensin II effects.
Exosomal circRNAs: Emerging Players in Tumor Metastasis
Authors: Zhou Hao , He Xiaoyun , He Yuxiang , Ou Chunlin , Cao Pengfei 
Published: December 2021

Metastasis is an important feature of malignant tumors, and is the primary cause of poor prognosis and treatment failure, in addition to representing a potentially fatal challenge for cancer patients. Exosomes are small extracellular vesicles 30–150 nm in diameter that transmit cargo, such as DNA, RNA, and proteins, as a means of intercellular communication. Exosomes play crucial roles in a range of human diseases, especially malignant tumors. A growing number of studies have verified that circRNAs can be enveloped in exosomes and transferred from secretory cells to recipient cells, thereby regulating tumor progression, especially tumor metastasis. Exosomal circRNAs regulate tumor cell metastasis not only by regulating the signaling pathways, but also by affecting the tumor microenvironment. Moreover, exosomal circRNAs have the potential to serve as valuable diagnostic biomarkers and novel therapeutic targets in cancer patients. In this review, we summarize the mechanism by which exosomal circRNAs modulate metastatic phenomena in various types of tumors, and put forward the prospects of clinical applications of exosomal circRNAs in tumor therapy.
An Apoptosis-Related Gene Prognostic Index for Colon Cancer
Authors: Tang Hanmin , Wang Jing , Luo Xuehui , Wang Qi , Chen Jie , Zhang Xinyue , Li Qiuting , Gao Chengyi , Li Yuesen , Han Suxia 
Published: December 2021

Purpose: To construct an apoptosis-related gene prognostic index (ARGPI) for colon cancer, and clarify the molecular and immune characteristics of the risk subgroup as defined by the prognostic index and the benefits of adjuvant chemotherapy. Integrating the prognostic index and clinicopathological risk factors to better evaluate the prognosis of patients with colon cancer.Methods: Based on the colon adenocarcinoma data in the TCGA database, 20 apoptosis-related hub genes were screened by weighted gene co-expression network analysis (WGCNA). Five genes constituting the prognosis model were determined by Cox regression and verified by the Gene Expression Omnibus (GEO) dataset. Then the molecular and immune characteristics of risk subgroups defined by the prognostic index and the benefits of adjuvant chemotherapy were analyzed. Finally, nomograms integrating ARGPI and four clinicopathological risk factors were used to evaluate the prognosis of patients with colon cancer.Results: The ARGPI was constructed based on the FAS, VWA5A, SPTBN2, PCK1, and TIMP1 genes. In the TCGA cohort, patients in the low-risk subgroup had a longer progression-free interval (PFI) than patients in the high-risk subgroup, which coincided with the results of the GEO cohort. The comprehensive results showed that the high-risk score was related to the enrichment of the cell cycle pathway, high mutation rate of TP53 and KRAS, high infiltration of T regulatory cells (Tregs), immunosuppressive state, and less chemotherapeutic benefit. However, low-risk scores are related to drug metabolism-related pathways, low TP53 and KRAS mutation rates, high infiltration of plasma cells, more resting CD4 memory cells and eosinophils, active immune function, and better chemotherapeutic benefits. Receiver operating characteristic curve of two-year progress prediction evaluation showed that the ARGPI had higher prognostic accuracy than TNM staging. Nomograms integrating ARGPI and clinicopathological risk factors can better evaluate the prognosis of patients with colon cancer.Conclusions: The ARGPI is a promising biomarker for determining risk of colon cancer progression, molecular and immune characteristics, and chemotherapeutic benefit. This is a reliable method to predict the prognosis of colon cancer patients. It also can assist doctors in formulating more effective treatment strategies.
The Association and Pathogenesis of SERPINA3 in Coronary Artery Disease
Authors: Li Bo , Lei Zhijun , Wu You , Li Bingyu , Zhai Ming , Zhong Yuan , Ju Peinan , Kou Wenxin , Shi Yefei , Zhang Xianling , Peng Wenhui 
Published: December 2021

Background: Serine proteinase inhibitor A3 (SERPINA3) has been discovered in the pathogenesis of many human diseases, but little is known about the role of SERPINA3 in coronary artery disease (CAD). Therefore, we aim to determine its relationship with CAD and its function in the pathogenesis of atherosclerosis.Methods: In total 86 patients with CAD and 64 patients with non-CAD were compared. The plasma SERPINA3 levels were measured using ELISA. Logistic regression analysis and receiver-operating characteristic (ROC) analysis were performed to illustrate the association between plasma SERPINA3 levels and CAD. In vitro, real-time PCR (RT-PCR) and immunofluorescence staining were used to determine the expression of SERPINA3 in atherosclerotic plaques and their component cells. Then rat aortic smooth muscle cells (RASMCs) were transfected with siRNA to knock down the expression of SERPINA3 and human umbilical vein endothelial cells (HUVECs) were stimulated by SERPINA3 protein. EdU assay and scratch assay were used for assessing the capability of proliferation and migration. The cell signaling pathway was evaluated by western blot and RT-PCR.Results: Patients with CAD [104.4(54.5–259.2) μg/mL] had higher levels of plasma SERPINA3 than non-CAD [65.3(47.5–137.3) μg/mL] (P = 0.004). After being fully adjusted, both log-transformed and tertiles of plasma SERPINA3 levels were significantly associated with CAD. While its diagnostic value was relatively low since the area under the ROC curve was 0.64 (95% CI: 0.55–0.73). Secreted SERPINA3 might increase the expression of inflammatory factors in HUVECs. Vascular smooth muscle cells had the highest SERPINA3 expression among the aorta compared to endothelial cells and inflammatory cells. The knockdown of SERPINA3 in RASMCs attenuated its proliferation and migration. The phosphorylated IκBα and its downstream pathway were inhibited when SERPINA3 was knocked down.Conclusions: Elevated plasma SERPINA3 levels were associated with CAD. SERPINA3 can increase inflammatory factors expression in HUVECs. It can regulate VSMCs proliferation, migration, and releasing of inflammatory factors through the NF-κB signaling pathway. Thus, SERPINA3 played a significant role in the pathogenesis of atherosclerosis.
Genetic Diversity, Structure, and Selective Sweeps in Spinacia turkestanica Associated With the Domestication of Cultivated Spinach
Authors: Gyawali Sanjaya , Bhattarai Gehendra , Shi Ainong , Kik Chris , du Toit Lindsey J. 
Published: December 2021

Genotype-by-sequencing (GBS) was used to explore the genetic diversity and structure of Spinacia turkestanica, and the selective sweeps involved in domestication of cultivated spinach, S. oleracea, from S. turkestanica. A total 7,065 single nucleotide polymorphisms (SNPs) generated for 16 Spinacia oleracea and 76 S. turkestanica accessions placed the S. oleracea accessions in one group, Q1, and the 76 S. turkestanica accessions, which originated from Central Asia, in two distinct groups, Q2 and Q3. The Q2 group shared greater genetic identity with the S. oleracea accessions, Q1, than the Q3 S. turkestanica group. Likewise, the S. oleracea Q1 group had a smaller Fst (0.008) with the Q2 group than with the Q3 group (Fst = 0.012), and a greater gene flow (Nm = 30.13) with the Q2 group than with the Q3 group (Nm = 21.83). The Q2 accessions originated primarily from Uzbekistan while the Q3 accessions originated mostly from Tajikistan. The Zarafshan Mountain Range appears to have served as a physical barrier that largely separated members of the Q2 and Q3 groups of S. turkestanica. Accessions with admixtures of Q2 and Q3 were collected primarily from lower elevations at the southern end of the Zarafshan Mountain Range in Uzbekistan. Selective sweep regions identified at 32, 49, and 52 Mb on chromosomes 1, 2, and 3, respectively, appear to have played a vital role in the domestication of S. oleracea as they are correlated with important domestication traits, including day length sensitivity for bolting (flowering). High XP-CLR scores at the 52 Mb genomic region of chromosome three suggest that a selective sweep at this region was responsible for early differentiation of S. turkestanica into two groups in Central Asia.