bluuebunny/crossref_metadata_2025_split huggingface dataset:
1-year follow-up of pulmonary CT and function in patients recovering from ARDS induced by H1N1 influenza
Authors: Xu Xiaoli , Tang Xiao , Ouyang Tao , Wang Zixing , Li Jialu , Gao Yanli , Zhai Xiaoli , Sun Bing , Yang Qi 
Published: December 2024

Abstract

Background Patients recovering from pneumonia-induced acute respiratory distress syndrome (ARDS) may demonstrate persistent lung abnormalities and declining pulmonary function. However, a comprehensive assessment of long-term outcomes in survivors of influenza A (H1N1) remains insufficiently explored. This study was to identify and characterize pulmonary radiological and functional impairments in patients with ARDS caused by H1N1 pneumonia during 1 year of follow-up after discharge.Methods We conducted a prospective, single-center, longitudinal cohort study on patients admitted to intensive care unit (ICU) due to H1N1 pneumonia complicated by ARDS from March 2016 to December 2020. Serial chest CT scans were obtained from admission to 1 year after discharge and longitudinally analyzed. The extent of CT abnormalities was semi-quantitatively scored in detail. Multiple linear regression analysis was performed to identify factors associated with CT score and diffusing capacity of the lung for carbon monoxide (DLCO) at follow-up.Results Among 345 patients diagnosed with ARDS, 92 individuals (26.7%) were diagnosed with laboratory-confirmed H1N1 pneumonia, 59 survivors (mean age, 47.2 years ± 13.2 [SD]; 43 men) completed follow-up and were included in the final analysis. At 1-year follow-up, 29/32 patients (90.6%) exhibited CT abnormalities and more than 80% were characterized by parenchymal bands and reticular lesions. In the multiple linear regression model, age and duration of ICU stay demonstrated a correlation with 1-year CT score (R2 = 0.574). Furthermore, smoking status and CT scores of reticular lesions were correlated with 1-year DLCO percent predicted (R2 = 0.386).Conclusions Over 90% of patients with H1N1-ARDS exhibited pulmonary parenchymal abnormalities 1 year following discharge, predominantly characterized by pulmonary fibrotic lesions, which were associated with a decline in pulmonary diffusion capacity.
Treatment of Severe Periodontitis using Exosome-Mediated Combination Therapies: A Retrospective Cohort Study
Authors: Froum Scott , Estrin Nathan E , Cho Hyun Jae , Farshidfar Nima , Ahmad Paras , Miron Richard J 
Published: December 2024

Abstract

Objectives: Exosomes are essential mediators/communicators of tissue repair via well-established mechanisms of action that include stimulatory effects on angiogenesis and cellular proliferation, differentiation, and matrix biosynthesis. This pioneering clinical study aimed to evaluate the effectiveness of exosomes specifically designed for periodontal regeneration (Periosomes) mixed with 90% anorganic bovine bone/10% collagen (ABBMC), and horizontal platelet-rich fibrin (H-PRF) for the treatment of advanced periodontal osseous defects at 6 months of healing.
Materials and Methods: This retrospective cohort study analyzed the medical records of stage-III (severe) periodontitis patients (from poor to hopeless prognosis) who underwent surgery using Periosomes. Eligible patients received standardized periodontal surgery with an ABBC scaffold, H-PRF, and Periosomes with a six-month follow-up. Complete periodontal charting, including probing depth (PD), gingival margin (GM), bleeding on probing (BOP), clinical attachment loss (CAL), gingival index (GI), plaque index (PI), and tooth mobility, were assessed at baseline and six-month follow-up. Pre and post-surgery radiographs were utilized to assess defect bone fill percentages. All data were statistically analyzed for associations with age, sex, and treatment effects, applying log transformations and correlations where needed. Significance was determined at p < 0.05.
Results: The study included 13 patients (8 females and 5 males) aged 29 to 73 years, with one-walled (60.9%) and two-walled (39.1%) periodontal defects. Healing was uneventful in all patients. The sites treated with Periosomes showed significant reductions in PD from baseline to 6 months in one-walled defects (8.50 ± 2.41 mm to 3.14 ± 0.77; p<0.0001) and two-walled defects (7.56 ± 1.13 mm to 3.22 ± 0.44; p<0.0001) as well as in CAL from 9.14 ± 3.01 mm to 4.79 ± 2.17 (p<0.0001) in one-walled defects and from 7.22 ± 1.56 mm to 3.56 ± 1.01 ( p<0.0001) in and two-walled defects. Radiographic fill averaged 79.5% in one-walled and 86.5% in two-walled defects, with improved BOP values in all but one patient.
Conclusions: To our knowledge, this is the first human clinical study assessing the use of exosomes in periodontal regenerative therapy. This study demonstrated that the use of exosomes/ABBMC/H-PRF was a safe and effective treatment for advanced periodontal osseous defects.
Clinical relevance: This is the first human study using exosomes for the treatment of intrabony defects with poor to hopeless prognosis with results demonstrating successful radiograph bone fill and improved clinical parameters.
Factors associated with local failure after stereotactic radiation to the surgical bed of patients with a single breast cancer metastasis
Authors: Haisraely Ory , Jaffe Marcia L , Lawrence Yaacov , Symon Zvi , Whol Anton , Kaisman-Elbaz Thaila , Cohen Zvi R , Taliansky Alicia , kaisdar-Person Orit 
Published: December 2024

Abstract

Introduction: Breast cancer brain metastases (BCBM) are increasingly common due to improved systemic therapies prolonging survival. This study evaluates local control and factors influencing outcomes in patients with resected BCBM treated with postoperative stereotactic radiotherapy (SRT).
Methods: A retrospective review included 62 patients with single resected BCBM treated with postoperative SRT from 2010 to 2022. The median follow-up was 28 months (range, 14-43). Variables analyzed included tumor size, biology, surgical corridor inclusion, radiation dose, and timing of SRT. Multivariable analysis was conducted using Cox regression.
Results: Local control at 12 months was 70.9%, with a median progression-free time of 13 months (95% CI: 9-21). Intracranial failure occurred in 41.6%. HER2-positive tumors were associated with better local control (HR: 0.76, p = 0.032), as were BED > 40 Gy (HR: 0.65, p = 0.028) and shorter intervals between surgery and SRT (<28 days, HR: 2.7 for delays >28 days, p = 0.015). Larger tumors (>5 cm, HR: 2.1, p = 0.021) and cystic lesions (HR: 1.5, p = 0.13) were associated with poorer outcomes. Surgical corridor inclusion improved control but was not significant on multivariable analysis. Radiation necrosis occurred in 13% of patients, predominantly asymptomatic.
Conclusion: Postoperative SRT offers reasonable control of BCBM. Factors such as HER2 positivity, timely SRT, and higher BED doses significantly affect outcomes. Future research should optimize dosimetric strategies and integrate systemic therapy to enhance local and intracranial control.
Efficacy of a novel one-step knife compared to conventional knife for colorectal endoscopic submucosal dissection: A prospective multicenter randomized controlled trial
Authors: Park Hong Jun , Kim Su Young , Baik Gwang Ho , Seo Myeongsook , Seo Hyun Il , Park Sung Chul , Kim Hyunil , Kim Hyun-Soo 
Published: December 2024

Abstract

Purpose
For the treatment of advanced colorectal neoplasms, colon endoscopic submucosal dissection (ESD) is a crucial technique, although it is time-consuming. The purpose of this study was to evaluate the efficacy of a recently developed one-step knife (OSK) in colon ESD and compare its performance with that of a conventional knife (CK).
Methods
Between July 2020 and November 2021, patients scheduled to undergo colorectal ESD were randomly assigned to either the OSK group or the CK group. The primary outcome was the total submucosal injection time. Additionally, total procedure time, treatment outcomes, adverse events, and operator convenience were analyzed.
Results
Data from 53 patients (28 in the OSK group and 25 in the CK group) were analyzed. The mean total injection time was marginally significantly reduced in the OSK group compared to the CK group (186 s [interquartile range, IQR: 116.8–249.5] vs. 265 s [IQR: 130.5–553.0], P = 0.082). The total procedure time tended to be shorter in the OSK group than in the CK group (15.5 min [IQR: 11.3–22.8] vs. 20 min [IQR: 13.5–42.5], P = 0.110). Resection rates and adverse events did not differ between the two groups. A greater proportion of endoscopists expressed high satisfaction with the OSK, particularly regarding submucosal injection.
Conclusion
Compared to the CK, the use of the OSK for colorectal ESD marginally significantly decreased the total injection and procedure times. The use of this newly developed endoscopic knife can potentially enhance the effectiveness and efficiency of colorectal ESD (Clinical Research Information Service: KCT0005123).
The Eye is a window to the heart, the Papilledema secondary to the intracranial pressure after the Heart Failure, Case Report of bicuspid Aortic valve (BAV)
Authors: Kazi Fezaan A. , Hammad Elsayed Mohamed , Gupta Salil J. , Khan Rayyan M. , Ansari Marium , Alizai Adeela M. 
Published: December 2024

Abstract

Purpose
There is currently a paucity of literature describing bilateral reversible disc edema as an early presenting sign of heart failure in the setting of bicuspid aortic valve disease. There is however a plethora of research indicating congenital bicuspid aortic valve (BAV) as a major risk factor for possible development of infective endocarditis in a patient’s lifetime.
Observations
A 26-year-old man presented with bilateral blurry vision with severe 4+ bilateral optic disc edema of one month duration and venous engorgement. The patient also complained of coughing when lying down, unintentional weight loss, joint swelling and fatigue. On further testing, the patient was found to have streptococcal bacteremia with aortic valve endocarditis, severe aortic regurgitation, congenital bicuspid aortic valve and decompensated class IV systolic heart failure. Following emergent aortic valve replacement, there was complete reversal of optic disc edema and symptomatic improvement.
Conclusions and Importance
Our patient’s clinical presentation demonstrates that optic disc edema can be an earlier sign of progressing heart failure and highlights the clinical progression of an increased risk of developing bacterial endocarditis for patients with BAV disease when other causes are not obvious. The life-threatening presentation of our case supports the importance of regular monitoring of valvular status and The observation of the optic disc edema and investigate the cause.
Preparing for pharmacy-based delivery of long-acting injectable antiretrovirals: a pre-implementation study
Authors: Cocohoba Jennifer , Cuca Yvette , Sherman Elizabeth , Hester Kelly , Udeani George , Sigua Michael , Saberi Parya 
Published: December 2024

Abstract

Background: Use of long-acting injectable antiretroviral therapy (LA-ART) for human immunodeficiency virus (HIV) treatment and prevention is increasing, but there are challenges which could limit broad expansion of these important treatments. The goal of this study was to explore attitudes, barriers, and facilitators for implementing LA-ART administration within community pharmacies.
Methods: We conducted a mixed-methods study focusing on pre-implementation aspects of community pharmacy-administered LA-ART. Pharmacists, clinic staff members, and persons with HIV completed a baseline survey followed by an individual semi-structured qualitative interview with questions based on the Consolidated Framework for Implementation Research (CFIR).
Results: A total of 63 participants (pharmacist n=19, clinic staff n=20, person with HIV n=24) from Alabama, California, Florida, and Texas were included in the study. Most pharmacist participants were employed in retail pharmacies that processed fewer than 500 prescriptions per day (75%) and most had more than 10 years of experience working with people with HIV (53%). Clinic staff participants were also highly experienced in working with people with HIV (55%). People with HIV enrolled in the study were either on oral antiretroviral therapy but interested in LA-ART (59%) or were already on LA-ART (29%). Clinics were the preferred location for LA-ART administration while community pharmacy was the second preferred location. Attitudes regarding pharmacy-based administration of LA-ART were mostly positive, with the primary facilitator being positive experiences or established relationships between clinics and pharmacies or persons with HIV and their pharmacies. Barriers included concerns about pharmacy staffing, training, space, privacy, and pharmacy reimbursement for services.
Conclusion: Involving community pharmacies in the administration of LA-ART could expand access to HIV treatment and prevention medications. Outlining best practices that leverage facilitators and overcome barriers can help clinics, pharmacy, and communities expand this novel model of care.
ClinicalTrials.Gov Registration: NCT05152953 (posted 12/10/2021)
Prognostic Role of Minimum Heart Rate in Elderly Heart Failure Patients with Hypertensive Heart Disease: An Analysis of MIMIC-IV Database
Authors: Li Xiaowei , Yang Yanli , Zhu Xiaolong , Xia Hongyuan , Tan Zhen 
Published: December 2024

Abstract

Background
Heart rate has been documented as a predictive factor in heart failure. However, its prognostic role in specific heart failure patients are diverse and not comprehensively identified.
Methods
A retrospective cohort study was conducted based onthe MIMIC-IV database. 2476 elderly (³ 60 years old) patients with heart failure and hypertensive heart disease were recruited. The participants were divided into a low minimum heart rate (MHR) (< 60 bpm) group and a high MHR (³ 60 bpm) group. Multivariable Cox proportional hazards regression analysis was implemented to evaluate the relationship between the two MHR groups and mortality. The association between prognosis and MHR as a continuous variable was elucidated via the restricted cubic spline model. The association in subgroups was assessed as well.
Results
Compared with high MHR, low MHR was significantly associated with higher 30-day all-cause mortalities (hazard ratio 1.309, 95% confidence interval 1.061 to 1.615, p = 0.012), 90-day all-cause mortality (hazard ratio 1.221, 95% confidence interval 1.020 to 1.462, p = 0.03), and 1-year all-cause mortality (hazard ratio 1.197, 95% confidence interval 1.028 to 1.393, p= 0.02) after adjustment for confounding variables. A U-shaped relationship between outcomes and MHR as a continuous variable was observed, with a nadir at MHR of approximately 50 to 60 bpm. The predictive value of low MHR was significant in women, but not in men.
Conclusions
We demonstratedthat MHR plays a prognostic role in elderly patients with heart failure and hypertensive heart disease. Low MHR predicts higher all-cause mortality, and the association conforms to a U-shaped pattern. Our findings extend those of previous studies and suggest the potential predictive value of HR in specific heart failure patients.
Investigation of climate change parameters using chaos analysis of Shiraz geomorphic basin, Fars Province, Iran
Authors: Askari Kaveh Ostad Ali 
Published: December 2024

Abstract

Applying the logic of chaos in understanding many details of natural phenomena is unexplainable. At this study, to analysis of process algorithms the climate changes of temperature and precipitation over the analysis of chaos in Shiraz geomorphic basin will be discussed.Shiraz geomorphic basin zoning Climatic changes of temperature and precipitation of 40 years of long-term data were used. Then, geomorphic basin physiognomic characteristics were examined at the most superficial layer and the climatic elements graphic were analyzed. The results of this study suggest that climate change of Shiraz basin geomorphic structure is a function of non-linear algebraic curves. Having knowledge about the distribution of temperature programming is considered necessary at natural and agricultural sources. According to the spatial distribution of these characteristics in this study geostatistical methods in the study of zoning and spatial distribution of temperature properties were evaluated in Fars province. With a mean of rainfall data in January, February and March, the seasonal rainfall time series for each station is calculated and then normalized correlation 31 matrix was created between data.
Identification of key genes in inflammatory bowel disease, characteristics of immune infiltration, and molecular mechanisms using multiomics analysis and Mendelian randomization
Authors: Chen Rongrong , Wu Guixi , Zeng Guannan , Chen Mengshi , Lu Shiyun 
Published: December 2024

Abstract

Purpose: We explored the possible influence of key genes in inflammatory bowel disease (IBD) to determine if they may be targets for treating or diagnosing IBD.
Patients and methods: We identified key genes associated with the pathogenesis of IBD through multiomics data and Mendelian randomization analysis. Furthermore, we investigated the role of these genes in disease progression, immune infiltration, and the underlying molecular mechanisms.
Results: We successfully identified six key genes (Adhesion G Protein-Coupled Receptor F1 (ADGRF1), CINP Kinetochore-Binding Protein (CINP), Equatorin (EQTN), Insulin-like Growth Factor 1 Receptor (IGF1R), Poliovirus Receptor (PVR), and Serpin Family A Member 9 (SERPINA9) associated with IBD. These genes exhibited unique expression patterns at the immune infiltration level. Gene set enrichment analysis revealed their enrichment in multiple key signaling pathways.
Conclusion: Further analysis of the transcription factor regulatory network and single-cell sequencing results revealed these genes’ possible role in disease progression, suggesting that they may be important targets for future treatment and diagnosis of IBD. Therefore, this article provides new insights into potential therapeutic targets for IBD.
Experimental study on the mechanical properties of coal and rock under heating- liquid nitrogen cooling impact cycling
Authors: Wang Linchao , Xue Yi , Liu Jia , Cao Xiaoshan , Liu Yong , Wang Pengshuai , Cao Zhengzheng 
Published: December 2024

Abstract

As a new type of anhydrous fracturing method, liquid nitrogen (LN2) fracturing provides a new way for the efficient exploitation of coalbed methane (CBM). In order to reveal the physical and mechanical properties and fracture characteristics of low permeability coal rock under LN2 fracturing, the heating and LN2 cold shock cycling test system was used to carry out LN2 fracturing tests, and the fracture pressure, acoustic emission (AE) characteristics and section morphology of coal rock under different LN2 cold shock cycling treatments were obtained. On this basis, the effect of LN2 cycling treatment on coal rock cracking was discussed. The results show that the average velocity of longitudinal wave is 1.421 km/s for the coal samples treated with 0 LN2 freeze-thaw cycles, and the average velocity of the coal samples treated with 15 LN2 freeze-thaw cycles is 0.256 km/s, and the decrease of wave velocity is 81.98%. The size and number of internal defects in coal samples increased significantly due to LN2 freeze-thaw. The tensile strength of coal samples in the 0-cycle group decreased from 0.943 MPa to 0.346 MPa in the 15-cycle group, with a decrease of 63.31%. After 15 freeze-thaw cycles of the coal sample and multiple LN2 cycles, the internal structure of the coal mass was fully damaged, resulting in full deterioration of the internal structure of the coal sample and the largest decrease in tensile strength. Under 0 cycles of fracturing, the original initial cracks were pressed and rubbed with each other, and the loading damage was small at this time. Multiple LN2 freeze-thaw cycles induce fracture initiation, development and connectivity of original fractures, and eventually form macroscopic fractures and begin to destroy, which is most obvious for coal sample defects. The box dimension and roughness of the 0-cycle coal sample section are 2.876 and 1371.376 μm, respectively, and the box dimension and roughness of the 15-cycle coal sample section are 2.993 and 2899.494 μm, respectively, and the growth rate is 4.07% and 111.43%, respectively. There is a positive correlation between roughness and box dimension, both of which increase with the increase of freeze-thaw cycle.
Do oil prices have an impact on extreme international capital flows?[1]
Authors: Liu Yanwei 
Published: December 2024

Abstract

Recently, extreme international capital flows have become an important research topic due to the frequent occurrence of large-scale international capital flows in many countries. This paper constructs an extreme international capital flow episode database, which can identify four types of extreme international capital flow episodes: “surge” (a sharp increase in gross capital inflows), “stop” (a sharp decrease in gross capital inflows), “flight” (a sharp increase in gross capital outflows), and “retrenchment” (a sharp decrease in gross capital outflows), utilizing the international capital flow data of 58 economies from 1980Q1 to 2021Q4. I analyze the impact of oil prices on extreme international capital flows using a Logit model based on the database. Empirical results show that, firstly, higher oil prices are associated with a higher probability of surge and a lower probability of stop and retrenchment. Secondly, oil prices can impact on extreme international capital flows directly or indirectly through the exchange rate channel. Thirdly, the drivers of extreme international capital flow episodes have a strong connection with temporal changes; in other words, the drivers vary over time.
Casein–Tb–Ti3C2 quantum dots ratiometric fluorescence probe for the detection of ciprofloxacin
Authors: Wang Chong , Wang Huixin , Ni Qingting , Zhou Wenjuan , Liu Dan 
Published: December 2024

Abstract

The development of a rapid and sensitive method for the detection of ciprofloxacin is crucial to ensure human health and safeguard the ecological environment. The present study demonstrates the synthesis of water-stable ratiometric fluorescence probe casein–Tb–Ti3C2 quantum dots (casein–Tb–Ti3C2 QDs) for precise detection of ciprofloxacin, based on the principle that ciprofloxacin effectively coordinates with lanthanide metal to enhance the fluorescence signal. In this approach, the I543 to I440 ratio was utilized as an indicator for monitoring changes in ciprofloxacin concentration. The ratiometric fluorescence probe demonstrated excellent linearity across a concentration range of 2–800 µM and exhibited high sensitivity, achieving a detection limit of 1.81 µM for ciprofloxacin. Furthermore, the ratiometric fluorescence probe was successfully employed for the detection of ciprofloxacin in milk and pork samples, achieving recoveries that ranged from 71.23–102.22%. Due to the advantages of high sensitivity and favorable selectivity, the potential of utilizing the ratiometric fluorescence probe for practical applications in ciprofloxacin detection.