bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-period Heartbeat Binaries from TESS Full-frame Images
Authors: Solanki Siddhant , Cieplak Agnieszka M. , Schnittman Jeremy , Baker John G. , Barclay Thomas , Barry Richard K. , Kostov Veselin , Kruse Ethan , Olmschenk Greg , Powell Brian P. , Ishitani Silva Stela , Torres Guillermo 
Published: December 2024

Abstract
We identify 240 short-period (P ≲ 10 days) binary systems in Transiting Exoplanet Survey Satellite data, 180 of which are heartbeat binaries. The sample is mostly a mix of A- and B-type stars and primarily includes eclipsing systems, where over 30% of the sources with primary and secondary eclipses show a secular change in their intereclipse timings and relative eclipse depths over a multiyear timescale, likely due to orbital precession. The orbital parameters of the population are estimated by fitting a heartbeat model to their phase curves and Gaia magnitudes, where the model accounts for ellipsoidal variability, Doppler beaming, reflection effects, and eclipses. We construct the sample’s period–eccentricity distribution and find an eccentricity cutoff (where e → 0) at a period of 1.7 days. Additionally, we measure the periastron advance rate for 12 of the precessing sources and find that they all exhibit prograde apsidal precession, which is as high as 9° yr−1 for one of the systems. Using the inferred stellar parameters, we estimate the general relativistic precession rate of the argument of periastron for the population and expect over 30 systems to show a precession in excess of 0.3° yr−1.
First record of the genus Anthomalachius Tshernyshev, 2009 (Coleoptera, Malachiidae) from China
Authors: Tong Junbo , Tshernyshev Sergei , Yang Yuxia , Liu Haoyu 
Published: December 2024

Anthomalachius Tshernyshev, 2009 is a small genus belonging to the tribe Malachiini in the family Malachiidae of the order Coleoptera, with six currently known species: A. spinosus (Erichson, 1840) from Central, Eastern and Southern Europe and North Africa; A. strangulatus (Abeille de Perrin, 1885) from Central Europe to Central Asia; A. davoodi Ezzatpanah, 2011 from Iran; A. senylia (Tshernyshev, 2000) from Uzbekistan and Kyrgyzstan; A. foveatus (Medvedev, 1964) from Kazakstan, Russia and Mongolia; A. pseudospinosus (Medvedev, 1964) from Kazakhstan and Turkey.
In this study, Anthomalachius Tshernyshev, 2009 is newly recorded from China upon the discovery of A. pseudospinosus (Medvedev, 1964) from Xinjiang Autonomous Region. The adult morphological characters are re-described in detail with illustrations of external appearance and relevant characters. The female ovipositor, pygidium and ultimate abdominal ventrite of A. pseudospinosus are illustrated and described for the first time.
Contrasts in perception of the interaction between non-native species and climate change
Authors: Perrin Sam Wenaas , Lundmark Carina , Wenaas Camilla Perrin , Finstad Anders Gravbrøt 
Published: December 2024

Over the last century, intensification of human movement has resulted in a large-scale redistribution of species worldwide. In recent decades, this phenomenon has been further compounded by climate change, creating complex challenges in the management of non-native species. As effective management can be hampered by gaps in communication and understanding between scientific researchers, natural resource managers and the wider public, assessing consensus between these groups is crucial.
Here, we adopt an explorative approach to analyse three key groups concerned with the management of freshwater ecosystems – recreational fishers, natural resource managers and scientific researchers. Our objective is to better understand the level of consensus regarding the interaction between non-native species and climate change.
We found that, while scientific researchers and managers had varying opinions on the management of non-native species as driven by climate change, recreational fishers were almost unanimously opposed to the potential presence of non-native species, regardless of the nature of their introduction. Additionally, definitions of what constitutes a non-native species varied greatly between and within the groups.
Our results underline both the current lack of consensus on the definition and management of non-native species and gaps in understanding between and within the three groups regarding both the nature of non-native species and the range-shifting effects of climate change.
Variability in the Evaluation and Treatment of Healthy Neonates With Uncomplicated Conjunctivitis
Authors: Nelson Camden , Deshler Bailee J. , Bernstein Brittany , Aronoff Stephen 
Published: December 2024

Purpose
To explore the current state of diagnosis and management of neonatal conjunctivitis.

Methods
Cosmos, an EHR-based, de-identified data set including more than 200 million patients, was used for this study. Neonates born between January 1, 2016 and December 31, 2022, discharged from the hospital by day 3 of life, and with an ambulatory visit within the first 4 weeks of life associated with a new diagnosis of neonatal conjunctivitis (SNOMED) or conjunctivitis (ICD-10 H10.*) were included. Cosmos slicer/dicer software was used to extract demographic, diagnostic, etiologic, and therapeutic data.

Results

A total of 1,870 of 7,325,276 (0.0255%) neonates with a hospital stay of 3 days or less met criteria for inclusion: 96.5% were from the United States, 16.2% were admitted to the hospital, and bacterial cultures were obtained from 21.3%. Congenital lacrimal duct stenosis was causative in 2.7% of patients. Important infectious agents included staphylococcal, streptococcal, or enterococcal species (2.5%),
Neisseria gonorrhoeae
(1.6%), and
Chlamydia trachomatis
(0.6%). No herpesviral or
Pseudomonas
infections were identified. Antimicrobial agents were prescribed to 93.7% of patients and given ophthalmically (79.5%), orally (11.4%), and parenterally (7.7%).

Conclusions
The evaluation and management of neonatal conjunctivitis within United States ambulatory settings are highly variable. Diagnostic studies are underused, resulting in limited etiologic data and a lack of susceptibility-guided treatment.

[
J Pediatr Ophthalmol Strabismus
. 20XX;X(X):XXX–XXX.]
Hematological Abnormalities in Patients with Chronic Kidney Disease (Stage V): A Cross-Sectional Observational Study
Authors: Bhattacharyya Purnakshi , Thakur Subrata , Das Dwijen 
Published: December 2024

Abstract

Background:
With over 10% of the global population affected, chronic kidney disease (CKD) has become one of the leading causes of death and suffering in the twenty-first century.[1] The Global Burden of Disease studies indicate that CKD has become a major cause of death globally, despite a decrease in mortality among individuals with end-stage CKD.[2-4] To lower the death rate, prompt implementation of all preventative and therapeutic measures, early diagnosis, monitoring, and treatment is necessary. The hematological markers change with CKD progression and are useful in determining the disease’s prognosis.

Aims:
We aimed to study abnormalities in various hematological parameters in patients with stage V CKD undergoing maintenance hemodialysis.

Settings and Design:
Hospital-based cross-sectional observational study.

Materials and Methods:
Hematological parameters such as red blood cell (RBC) count, hematocrit (HCT), Hb%, mean corpuscular volume, mean corpuscular hemoglobin (MCH), MCH concentration, RDW, platelet count, and WBC count along with patient’s age and gender were assessed in CKD patients.

Statistical Analysis Used:

P value and linear progression curve have been used.

Results:
Out of 71 patients, 65% were males and 35% were female with an average age of 48 years. The mean hemoglobin concentration was 10.7%, with a mean RBC count of 3.121 million, mean hemotocrit value of 26.05%, and decrease in platelet count with average of 1.34 lakhs. In 55% patients, the RDW value was more than normal limit with a linear progression, with an increase in the serum creatinine value.

Conclusions:
All hematological parameters showed significant variation, whereas the RDW value showed a linear progression with serum creatinine.
Value of neutrophil gelatinase-associated lipocalin in the diagnosis of renal disorders in children with glycogen storage disease
Authors: Mohamed Nashwa F. , Behairy Ola G. , Assar Effat H. , Fayek Hend T. , Abdelmotaleb Dina S. 
Published: December 2024

Purpose
This study aimed to evaluate the value of urinary neutrophil gelatinase-associated lipocalin (NGAL) in the diagnosis of renal disorders in children with glycogen storage disease (GSD).

Patients and methods
This cross-sectional study, which was conducted at Benha University Hospital, Egypt, included 50 children with GSD and apparently healthy 50 children as a control group. The level of NGAL was measured in urine by enzyme-linked immunosorbent assay and compared between groups.

Results
The GSD group had statistically significant higher urinary NGAL (147.6±38.8 ng/ml) compared to the control group (102.1±11.4 ng/ml, P<0.001). Urinary NGAL was higher in patients with microalbuminuria, kidney injury (RIFLE >2), and patients with a higher degree of liver fibrosis. At a cutoff point more than or equal to 154 ng/ml, urinary NGAL could detect cases with microalbuminuria with a sensitivity of 83.3% and specificity of 94.7%. At a cutoff point more than or equal to 172 ng/ml, urinary NGAL could detect cases with acute kidney injury (RIFLE >2), with a sensitivity of 100% and specificity of 100%.

Conclusion
Urine NGAL demonstrates superior efficacy as a biomarker for the precocious identification of renal dysfunction in pediatric patients afflicted with GSDs.
Endocan as a diagnostic and prognostic biomarker for pediatric sepsis in Mansoura University Children’s Hospital
Authors: Abdallah Fatima I. , Elbayoumi Mohamed A. , Elshabrawy Walaa O. , Zeid Mayada S. 
Published: December 2024

Background
Sepsis is a life-threatening condition causing high mortality in pediatrics with challenging diagnosis and increasing real need for sepsis markers. Endocan is a promising marker for diagnosis and prognosis of adult sepsis with the scarcity of published data in pediatrics.

Aim
To reveal the diagnostic and prognostic role of serum Endocan level as a biomarker for pediatric sepsis.

Patients and methods
In an observational, prospective cohort study, from November 2021 to October 2022, on 60 patients; 30 were diagnosed with sepsis according to the presence of proven infection plus two signs of systemic inflammatory response and revised by The Phoenix Sepsis Score. Those patients admitted to pediatric intensive care unit in Mansoura University Children’s Hospital, serum Endocan level was measured first 3 days and after 7 days of admission and compared to 30 control nonseptic patients.

Results
Serum Endocan level among patients on the third and seventh days of admission was significantly higher than the control group (P≤0.001). Serum Endocan decreased in septic patients on the seventh day in comparison to the third day but with no statistical significance. There was a statistically significant positive correlation between serum Endocan on the seventh day and PRISM score, capillary refill time, mechanical ventilation stay, C-reactive protein, and liver function. There was a statistically significant negative correlation between serum Endocan after 7 days and hemoglobin, platelet, and neutrophil count. Serum Endocan level after 7 days was statistically significantly higher in dead or worsening patients. The cutoff point for diagnosis of sepsis on the third day and seventh days was 17.55 and 13.6 pg/ml, with sensitivity 78.3 and 78.3%. Specificity 87.7 and 80%, respectively.

Conclusion
Endocan is a good diagnostic and prognostic marker for pediatric sepsis.
Clinical Characteristics and Risk Factors for Seizures to Recur in Calcified Neurocysticercosis: Prospective Cohort Study
Authors: Verma Archana , Kumar Alok , Sachan Divyata 
Published: December 2024

Abstract

Aim:
Calcification of degenerating neurocysticercosis (NCC) is common and likely to occur late in the degenerative process and is important for seizure foci. The present study was aimed at identifying the clinical and radiological variables associated with seizure recurrence in people with single or multiple calcified NCC lesions.

Material and Methods:
We evaluated 85 adult patients with calcified NCC lesions for recurrence of seizures during the follow-up period of one year.

Results:
The mean age of the study population was 24.49 ± 9.17 years. Nocturnal seizures were present in 43.5% and serial seizures in 42.4%. A single calcified lesion was present in 61 (71.8%), and perifocal oedema surrounding the calcified lesions was present in 38 (44.7%). Recurrence of seizures was noted in 37 (43.5%) of the cases. On multivariate analysis, the factors that were significantly associated with the recurrence of seizures were: nocturnal seizures [OR: 0.054 (0.015–0.199)], serial seizures [OR: 0.141 (0.041–0.485)], and perifocal oedema [OR: 0.031 (0.008–0.129)].

Conclusion:
In our study, serial seizures, nocturnal seizures, and perifocal oedema were linked with the recurrence of seizures in calcified NCC lesions. Perilesional oedema should be treated aggressively with anti-inflammatory/immunosuppressive therapy as well as with anti-seizure medication.
Challenges in The Diagnosis of Ischemic stroke, Tuberculous Meningitis, and Co-Infection with HIV in a Socially Isolated Elderly Patient
Authors: Huang Han-Ke , Chuang Chieh-Sen 
Published: December 2024

Abstract

Background:
Ischemic stroke has been a common cause of death and disability in Taiwan, particularly among the elderly. Social isolation is a significant issue in an aging society, which can be associated with delayed medical care and difficulties in diagnosis.

Case:
A 76-year-old man presented with altered mental status, left-sided weakness, and declining cognitive function over three months. He had limited social connections and an unknown medical history. Initial brain imaging showed communicating hydrocephalus. Cerebrospinal fluid analysis revealed increased lymphocytes and high protein levels. Further imaging revealed multiple hyperintense lesions in the brain’s white matter and acute ischemic stroke in specific areas. The patient was diagnosed with tuberculosis and HIV coinfection, leading to probable tuberculous meningitis, HIV encephalopathy, and pneumocystis jirovecii pneumonia. Treatment with antituberculous agents, antibiotics, and steroids improved the patient’s level of consciousness.

Conclusion:
Addressing social isolation and altered consciousness in elderly individuals requires a thoughtful approach. Reconsidering the differential diagnosis is crucial when it doesn’t match the clinical severity. Clinicians should consider rare co-occurrences like ischemic stroke, TBM, and HIV infection in atypical TBM cases. A biopsychosocial perspective helps gather a comprehensive medical history for holistic care. Early diagnosis and timely intervention are vital for better outcomes in severe infections.
Dengue hemorhagic fever associated hemophagocytc lymphohistiocytosis in primigravida: A case report
Authors: Bhellum Pyrus , Kumar Rakesh , Bora Rishabh , Kumar Bharat 
Published: December 2024

Rationale:
Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe complication of dengue virus infection, associated with high mortality. We report a case of a 9-week primigravida presenting with high grade fever spikes and a positive Dengue NS1 antigen. The patient exhibited worsening clinical parameters, including cytopenias.

Patient concerns:
A primigravida at 9th week of gestation and this condition has limited diagnostic modalities and treatment options for HLH.

Diagnoses:
HLH secondary to dengue hemorrhagic fever.

Outcomes:
Intravenous steroids were initiated with monitoring of laboratory and clinical parameters. The patient recovered successfully after initiation of intravenous steroids. Oral steroids were subsequently tapered over an next eight-week period, leading to a successful recovery.

Lessons:
This case is unique due to the interplay between dengue virus infection, HLH, and early pregnancy, characterized by overlapping clinical symptoms and limited treatment options. Prompt initiation of intravenous steroid therapy resulted in significant clinical improvement. This case highlights the critical importance of early identification and treatment of dengue associated HLH to reduce mortality. Furthermore, it underscores the urgent need for focused research on HLH in pregnant patients, particularly in low and middle income countries.
Clinical characteristics and outcome of pregnant women presented with thrombocytopenia: an Egyptian single-center prospective study
Authors: Abdelaty Mona M. , Gamaleldin Sally M , Haider Mostafa H. , Aboelagha Ahmed S. , Abdeen Nashwa S. M. , Abdalla Reham M. A. 
Published: December 2024

Background
Thrombocytopenia during pregnancy has a wide range of etiologies and clinical manifestations. A benign course is usually expected in most pregnancies. However, it can be associated with major obstetric complications. Early interdisciplinary approach of thrombocytopenia in pregnancy is necessary for the best care of the expectant mothers and neonates. We evaluate the etiologies, severity of thrombocytopenia, clinical characteristics, and their impact on feto-maternal outcomes in 60 Egyptian pregnant women.

Results
The maternal age ranged from 19 to 41 years and the majority were primigravida 55%. Mild thrombocytopenia was found in 45% of patients and 20% presented with platelet counts less than 50 × 109/L. Gestational thrombocytopenia was the most common cause followed by hypertensive pregnancy disorders. Immune thrombocytopenia affected 11.7%, systemic lupus erythematosus was documented in three patients and acute leukemia in one patient. Pregnancy unrelated causes were associated with significant earlier presentation, higher incidence of bleeding symptoms, and lower platelet counts. No significant association between maternal thrombocytopenia and neonatal complications was noted.

Conclusion
Maternal/neonatal complications depend primarily on the etiology of thrombocytopenia. Gestational thrombocytopenia was the most prevalent cause and was associated with better feto-maternal outcomes compared with other causes. Hematologists, nephrologists, and rheumatologists should be consulted for cases with a severe or atypical presentation due to pregnancy unrelated causes as early management may significantly improve the outcomes of pregnant women and their offspring.
Evaluation of metabolic syndrome and growth disorder in long-term survivors of hematopoietic stem cell transplantation in children
Authors: Ibrahim Wafaa E. , Abdelmakhsood Abeer A. , Moharram Wessam A. , AbouSaleh Asmaa I.B. , El Kader Salwa M.A. 
Published: December 2024

Background
Treatment improvement in hematopoietic stem cell transplantation (HSCT) in children has lowered HSCT-associated mortality rate, with increased long-term survivors’ complications. The metabolic syndrome (MetS), as well as growth failure observed among HSCT survivors, can be related to the patient’s primary illness or a complication of the HSCT.

Aim
To assess the frequency and possible risks of MetS and growth failure among HSCT survivors treated at our center.

Patients and methods
This study included 22 patients who underwent HSCT between 2011 and 2020 at the Pediatric Blood and Marrow Transplant Unit, Ain Shams University Hospital and survived for more than 1 year after HSCT with a mean age of 12.95 years, and a mean duration posttransplant of 5.95 years. Three patients were transplanted for malignant diseases, and all patients received chemotherapy only in a conditioning regimen. Detailed medical history, physical examination, and laboratory assessment, including complete blood count, fasting plasma glucose, fasting insulin, homeostatic model assessment of insulin resistance, glycated hemoglobin, fasting lipid profile, thyroid function and growth hormone stimulation tests for patients with height less than −3 SD were done.

Results
The frequency of MetS in our study was 4.5%, with 40.9% showing two components of MetS and 18.1% having one component of MetS. Dyslipidemia was detected in 68.2% with 50% developed hypertriglyceridemia, 45.4% had low high-density lipoprotein-cholesterol. 36.4% showed insulin resistance, 4.5% had impaired fasting glucose, yet none was diabetic. 9.1% had elevated blood pressure, and 4.5% had abdominal obesity. Multivariate analysis confirmed a significant positive association (P=0.019) between acute graft-versus-host disease and insulin resistance and a significantly elevated free T3 among patients with insulin resistance (P=0.011).

Conclusion
The current study proved a high prevalence of MetS components, specifically dyslipidemia (68.2%) and insulin resistance (36.4%) among HSCT survivors, mandating regular screening of MetS components in the long-term follow-up of those survivors.
Evaluation of serum ferritin and its correlation with biomarkers of early onset neonatal sepsis
Authors: Abdou Rania M. , Hamza Mohamed T. M. , Iskander Sandra M. , Hussein Mohamed H. M. 
Published: December 2024

Background
A clinical illness known as neonatal sepsis is defined by disseminated infection symptoms and bacteremia during the first 30 days of life. It is categorized as early-onset neonatal sepsis and late-onset neonatal sepsis It is one of the leading causes of mortality and morbidity worldwide. Neonatal sepsis can be diagnosed by blood culture but it takes a lot of time. Serum ferritin as an acute phase Reactant can be used as a Marker of neonatal sepsis, also it is found to be a better indicator of mortality in neonatal sepsis.

Aim
Examine the diagnostic usefulness of procalcitonin, interleukin-6 (IL-6), C-reactive protein (CRP), and serum ferritin as indicators of early-onset neonatal sepsis and compare these markers with various clinical and laboratory analysis results of neonatal sepsis.

Patients and methods
A total of 40 newborns admitted to the Intensive Care Unit of Neonates (Ain Shams Pediatrics Hospital) took part in the study. Aged from 1 to 3 days of life, 20 neonates were proven Neonatal sepsis, and the other 20 as control Age-matched neonates without any major clinical or laboratory evidence of Sepsis. All children underwent a clinical evaluation that involved taking their history, routine investigation (CBC, CRP, and blood culture) also determination of serum ferritin, IL-6, and procalcitonin

Results
Procalcitonin and IL-6 both showed higher specificity as well as sensitivity than serum ferritin.

Conclusion
A positive correlation has been shown between CRP and serum ferritin. Furthermore, there is a positive association between procalcitonin and IL-6.