bluuebunny/crossref_metadata_2025_split huggingface dataset:
UPAYA MENINGKATKAN KINERJA PEMASARAN PADA ERA DIGITAL (STUDI EMPIRIS PADA UKM DI KOTA BEKASI)
Authors: Mansur Amin , Setyaningrum Any , Muslikh Muslikh 
Published: March 2021

ABSTRAKTujuan penelitian ini adalah untuk mengetahui bagaimana upaya meningkatkan kinerja pemasaran usaha kecil dan menengah (UKM) pada era digital di kota Bekasi. Disamping itu, penelitian ini juga bertujuan untuk menguji pengaruh orientasi pasar, inovasi produk, daya saing produk terhadap kinerja pemasaran pada era digital. Penelitian dilakukan melalui survey dengan cara menyebarkan kuesioner kepada 114 pelaku UKM di kota Bekasi. Pengambilan sampel penelitian menggunakan non probability sampling dengan teknik purposive sampling. Hasil penelitian menunjukkan bahwa: orientasi pasar dan inovasi produk berpengaruh secara signifikan terhadap daya saing produk . Orientasi pasar dan inovasi produk berpengaruh signifikan terhadap kinerja pemasaran, daya saing produk berpengaruh signifikan terhadap kinerja pemasaran UKM di kota Bekasi.Kata kunci: Orientasi Pasar, inovasi produk, daya saing , kinerja pemasaran, era digital, UKM. ABSTRACTThe objective of this study was how to increase market performance micro and small medium enterprises in Bekasi..This study olso examines the effect of market orientation, innovation on market erformance and competitivness as moderating variabel .The survey method was conducted by distributing the qquesioneries to 114 micro and small medium enterprises .The sampling method used in this study is non probability sampling with purposive technique. The results indicate that market orientation and innovation were influanced significantly on competitiveness. Maraket orientation was influencend on market erformance. Innovation was influence on market performance, competitiveness was influenced on market performance Keyword: market orientation, innovation, competitiveness, market performance , digital era, small and medium enterprises
IDENTIFIKASI FAKTOR RISIKO TERJADINYA KOLONISASI SPESIES CANDIDA DI RONGGA MULUT PADA INDIVIDU SEHAT (PENELITIAN PADA MAHASISWA & MAHASISWI FKG UI)
Authors: Audiawati Audiawati , Aliyah Pradono Siti , Rahmayanti Febrina 
Published: March 2021

Introduction : Cases of oral candidiasis are commonly found, both in healthy individuals and immunecompromise patients, however publications of Candida carrier in the oral cavity of healthy population and risk factors for colonization in Indonesia are hardly available. Objective : This study was aimed to analyze the type and number of Candida colonies and identify risk factors in the oral cavity of apparenthly health FKG UI students. Material and methods : the specimens were taken from 195 subjects with oral rinse technique for identification using culture medium CHROMagar® and Sabaraoud dextrose agar. Results and discussion : Candida species were found in the 107 subjects oral cavity (54.87%), being Candida albicans was is the predominant species (52.33%). Some 88 subjects (82.24%) was dominant in the number of colonies less than 400 CFU/ml, while the rest had colony of more than 400 CFU/ml (17.76%). Candida colony grew dominantly in single colony (90.65%), and the others showed multi-species colonies (9.34%). Risk factors identified included age; gender; hormonal; blood type O; denture; orthodontic appliances; unstimulated salivary flow; pH of saliva; smoking, alcohol and oral cleaning habit; and oral health status. By using a statistical Pearson chi-square test, no significant relationship was found between risk factors and number of Candida colonies in the oral cavity p less than 0.05. Conclusion : there was no one single risk factor for Candida colonization, but combination of various risk factors for demographis, local and systemic was observed
Pengetahuan dan Sikap mengenai Infertilitas pada Mahasiswa Fakultas Kedokteran dan Fakultas Non Kedokteran Universitas YARSI
Authors: Khaerunnisa Annisha Jehan , Mirfat Mirfat 
Published: March 2021

Infertility is a disease characterized by the failure to establish a pregnancy after 12 months of regular unprotected sexual intercourse. As the incidence of infertility increases, knowledge and attitude about infertility on students may decrease the incidence of infertility in the future. The aim of this study is to determine and compare the knowledge and attitude regarding infertility among YARSI University students based on their faculty and gender. This was an analytic study with cross-sectional design, which conducted on September until November 2016. The samples were using bachelor’s degree students from 2013 classes of YARSI University in total 86 respondents. Data were obtained by using questionnaire that has been validated. This study used univariate and bivariate analysis method.The results of this study showed that majority of students have moderate level of knowledge regarding infertility (46,5%) and good attitude towards infertility (97%). Significant difference was found in knowledge about infertility between faculties (p value 0,000; less than 0,05). While there was no significant difference in knowledge about infertility between genders with (p value 0,471; more than 0,05). Significant differences were also not found in attitudes regarding infertility between faculties with (p value 0,399; more than 0.05) and genders with (p value 0,083; more than 0.05). Based on the research results medical students have a better knowledge about infertility than non-medical student. Faculty affect the knowledge about infertility, but do not affect the attitude towards infertility. Meanwhile, genders do not affect both knowledge and attitude towards infertility. Thus, it is important to improve student’s knowledge and attitude regarding infertility
Gambaran Klinis Stomatitis Aftosa Rekuren pada Pasien dengan Infeksi Human Immunodeficiency Virus (Laporan Kasus)
Authors: Nurfianti Nurfianti , Pradono Siti Aliyah 
Published: March 2021

Recurrent oral ulceration usually induced pain and influence patient’s quality of life. Reccurent Aphthous Stomatitis (RAS) is a common disorder with recurring ulcers, affecting the oral mucosa, painful and no other signs of systemic disease. Human Immunodeficiency Virus (HIV) is considered as a predisposing factor for RAS. Lesion of RAS associated with HIV, usually more severe, longer lasting to healing and non specific clinical features. This case report describe clinical features of recurrent oral ulceration in HIV patient. A 23 year old female came with complaint oral ulceration in soft palate and tongue since 2 months ago. Patient was diagnosis HIV since seven years ago. Several examinations were done to explore possibility of opportunist infection in HIV patient. Intra oral examination showed regular ulcer, with yellowish base, surrounding erythematous halo. The locations of ulcer were in labial mucosa, dorsum and ventral of the tongue, and soft palate. Ulceration in keratinized mucosa and non keratinized mucosa, gives un-specific features mimicking Tuberculous oral ulcer but in this case there was no indurations on all ulcer. Based on anamnesis and clinical examination, the diagnosis of this case is RAS with differential diagnosis of Tuberculous oral ulcer. The therapy given was gold standard of RAS, the outcome was successful without TB therapy. RAS on HIV Patient can give unspecific clinical features, mimicking oral manifestation of opportunist infection commonly occurred in HIV patient.
Multi Modal Gender Recognition for Gender-Based Marketing Using Depth Camera
Authors: Setyonugroho Adityo , Purnama James , Galinium Maulahikmah 
Published: March 2021

This research is conducted to prove that gender recognition by computer which can be done in real time by using depth camera. Gender recognition can be used on many industries, such as security, marketing, and other sectors. The purpose of this research is to detect gender by using images of user (RGB image) and voice. Furthermore, gender-based marketing is used for the implementation of this system. By using multi modalities, the result is more accurate than only using one factor. Image processing algorithm is used on processing facial image, which is Linear Discriminant Analysis (LDA) algorithm. Furthermore, gender can also be detected by special frequency of each gender speech. Autocorrelation is one of the methods that is able to detect pitch from detected audio. Kinect for Windows v2 was carried out as visual and audio sensor. This research proved that gender can be detected by using those modalities with right algorithm. Several problems are also found during the experiments, such as input data problem, not matching algorithm, and small percentage of accuracy. In conclusion, detecting gender can be done by computer (real time or not) and several ideal conditions must be made to get proper and high accuracy result, such as person distances from camera, lighting, image size.
Privacy in Social Media
Authors: Hirawan Jeffry , Rasyid Itmam Al 
Published: March 2021

Nowadays social networks become very common. People use social media to keep people in touch, businesses, organizations, and many more. The information you share with your friends in the social media allows them easily to keep in touch with you. However beside friends, colleges, relatives, there are many people that are interested in the private information on social media. Identity thieves, scam artists, debt collectors, stalkers, companies use social networks to gather information. Companies that use social networks for getting information about people are intended to personalize their services for the users and to sell to advertisement. In this paper we will discuss the advantage and disadvantage of using social media and what kind of information is safe to post and how to protect it.
Screening for Mycobacterium tuberculosis Infection Using Beijing/K Strain-Specific Peptides in a School Outbreak Cohort
Authors: Hong Ji Young , Kim Ahreum , Park So Yeong , Cho Sang-Nae , Dockrell Hazel M. , Hur Yun-Gyoung 
Published: March 2021

BackgroundThe Beijing strain of Mycobacterium tuberculosis (M. tb) has been most frequently isolated from TB patients in South Korea, and the hyper-virulent Beijing/K genotype is associated with TB outbreaks. To examine the diagnostic potential of Beijing/K-specific peptides, we performed IFN-γ release assays (IGRA) using a MTBK antigen tube containing Beijing/K MTBK_24800, ESAT-6, and CFP-10 peptides in a cohort studied during a school TB outbreak.MethodsA total of 758 contacts were investigated for M. tb infection, and 43 contacts with latent TB infection (LTBI) and 25 active TB patients were enrolled based on serial screening with QuantiFERON-TB Gold In-Tube tests followed by clinical examinations. Blood collected in MTBK antigen tubes was utilized for IGRA and multiplex cytokine bead arrays. Immune responses were retested in 24 patients after TB treatment, and disease progression was investigated in subjects with LTBI.ResultsTotal proportions of active disease and LTBI during the outbreak were 3.7% (28/758) and 9.2% (70/758), respectively. All clinical isolates had a Beijing/K M. tb genotype. IFN-γ responses to the MTBK antigen identified M. tb infection and distinguished between active disease and LTBI. After anti-TB treatment, IFN-γ responses to the MTBK antigen were significantly reduced, and strong TNF-α responses at diagnosis were dramatically decreased.ConclusionsMTBK antigen-specific IFN-γ has diagnostic potential for differentiating M. tb infection from healthy controls, and between active TB and LTBI as well. In addition, TNF-α is a promising marker for monitoring therapeutic responses. These data provide informative readouts for TB diagnostics and vaccine studies in regions where the Beijing/K strain is endemic.
NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte Size in Human and Rodent Adipose Tissue
Authors: Bové María , Monto Fermi , Guillem-Llobat Paloma , Ivorra M Dolores , Noguera M Antonia , Zambrano Andrea , Sirerol-Piquer M Salome , Requena Ana Cristina , García-Alonso Mauricio , Tejerina Teresa , Real José T. , Fariñas Isabel , D’Ocon Pilar 
Published: March 2021

Neurotrophin-3 (NT3), through activation of its tropomyosin-related kinase receptor C (TrkC), modulates neuronal survival and neural stem cell differentiation. It is widely distributed in peripheral tissues (especially vessels and pancreas) and this ubiquitous pattern suggests a role for NT3, outside the nervous system and related to metabolic functions. The presence of the NT3/TrkC pathway in the adipose tissue (AT) has never been investigated. Present work studies in human and murine adipose tissue (AT) the presence of elements of the NT3/TrkC pathway and its role on lipolysis and adipocyte differentiation. qRT-PCR and immunoblot indicate that NT3 (encoded by NTF3) was present in human retroperitoneal AT and decreases with age. NT3 was also present in rat isolated adipocytes and retroperitoneal, interscapular, perivascular, and perirenal AT. Histological analysis evidences that NT3 was mainly present in vessels irrigating AT close associated to sympathetic fibers. Similar mRNA levels of TrkC (encoded by NTRK3) and β-adrenoceptors were found in all ATs assayed and in isolated adipocytes. NT3, through TrkC activation, exert a mild effect in lipolysis. Addition of NT3 during the differentiation process of human pre-adipocytes resulted in smaller adipocytes and increased uncoupling protein-1 (UCP-1) without changes in β-adrenoceptors. Similarly, transgenic mice with reduced expression of NT3 (Ntf3 knock-in lacZ reporter mice) or lacking endothelial NT3 expression (Ntf3flox1/flox2;Tie2-Cre+/0) displayed enlarged white and brown adipocytes and lower UCP-1 expression.ConclusionsNT3, mainly released by blood vessels, activates TrkC and regulates adipocyte differentiation and browning. Disruption of NT3/TrkC signaling conducts to hypertrophied white and brown adipocytes with reduced expression of the thermogenesis marker UCP-1.
Modulation of the Corticomotor Excitability by Repetitive Peripheral Magnetic Stimulation on the Median Nerve in Healthy Subjects
Authors: Jia Yanbing , Liu Xiaoyan , Wei Jing , Li Duo , Wang Chun , Wang Xueqiang , Liu Hao 
Published: March 2021

Objective: We aimed to examine the effects of repetitive peripheral nerve magnetic stimulation (rPNMS) on the excitability of the contralateral motor cortex and motor function of the upper limb in healthy subjects.Methods: Forty-six healthy subjects were randomly assigned to either a repetitive peripheral nerve magnetic stimulation group (n = 23) or a sham group (n = 23). The repetitive peripheral nerve magnetic stimulation group received stimulation using magnetic pulses at 20 Hz, which were applied on the median nerve of the non-dominant hand, whereas the sham group underwent the same protocol without the stimulation output. The primary outcome was contralateral transcranial magnetic stimulation (TMS)-induced corticomotor excitability for the abductor pollicis brevis of the stimulated hand in terms of resting motor threshold (rMT), the slope of recruitment curve, and peak amplitude of motor evoked potential (MEP), which were measured at baseline and immediately after each session. The secondary outcomes were motor hand function including dexterity and grip strength of the non-dominant hand assessed at baseline, immediately after stimulation, and 24 h post-stimulation.Results: Compared with the sham stimulation, repetitive peripheral nerve magnetic stimulation increased the peak motor evoked potential amplitude immediately after the intervention. The repetitive peripheral nerve magnetic stimulation also increased the slope of the recruitment curve immediately after intervention and enhanced hand dexterity after 24 h. However, the between-group difference for the changes was not significant. The significant changes in hand dexterity and peak amplitude of motor evoked potential after repetitive peripheral nerve magnetic stimulation were associated with their baseline value.Conclusions: Repetitive peripheral nerve magnetic stimulation may modulate the corticomotor excitability together with a possible lasting improvement in hand dexterity, indicating that it might be helpful for clinical rehabilitation.
The Impact of Prolonged Mechanical Ventilation on Overall Survival in Patients With Surgically Treated Brain Metastases
Authors: Schuss Patrick , Schäfer Niklas , Bode Christian , Borger Valeri , Eichhorn Lars , Giordano Frank A. , Güresir Erdem , Heimann Muriel , Ko Yon-Dschun , Landsberg Jennifer , Lehmann Felix , Potthoff Anna-Laura , Radbruch Alexander , Schaub Christina , Schwab Katjana S. , Weller Johannes , Vatter Hartmut , Herrlinger Ulrich , Schneider Matthias 
Published: March 2021

ObjectiveSurgical resection represents a common treatment modality in patients with brain metastasis (BM). Postoperative prolonged mechanical ventilation (PMV) might have an enormous impact on the overall survival (OS) of these patients suffering from advanced cancer disease. We therefore have analyzed our institutional database with regard to a potential impact of PMV on OS of patients who had undergone surgery for brain metastases.Methods360 patients with surgically treated brain metastases were included. The definition of PMV consisted of postoperative mechanical ventilation lasting for more than 48 hours. Analysis of survival incorporating established prognostic factors such as age, location of BM, and preoperative physical status was performed.Results14 of 360 patients with BM (4%) suffered from postoperative PMV after surgical treatment of BM. Patients with PMV presented in a significantly more impaired neurological condition preoperatively than patients without (p&lt;0.0001). Multivariate analysis determined PMV to be a significant prognostic factor for OS after surgical treatment in patients with BM, independent of other predictive factors (p&lt;0.0001).ConclusionsThe present study demonstrates postoperative PMV as significantly related to poor OS in patients with surgically treated BM. Postoperative PMV is a so far underestimated prognostic predictor, but might be utilized for optimized patient management early in the postoperative phase. For this purpose, the results of the present study should encourage the initiation of further scientific efforts.
The Efficacy of Ginsenoside Rg3 Combined with First-line Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Peng Ze , Wu Wen Wen , Yi Ping 
Published: March 2021

Background: For advanced non-small cell lung cancer (NSCLC) patients, first-line chemotherapy is the main treatment in the clinic despite its efficacy is limited and adverse effects are always inescapable. Ginsenoside Rg3, an anti-cancer active ingredient by suppressing angiogenesis, has been increasingly widely used as an adjuvant in first-line chemotherapy for advanced NSCLC to optimize treatment in China. However, no comprehensive meta-analyses have been conducted to estimate the efficacy and safety of the therapy combining ginsenoside Rg3 and first-line chemotherapy in advanced NSCLC patients.Methods: Randomized controlled trails using a combination of first-line chemotherapy and ginsenoside Rg3 for advanced NSCLC patients were searched and selected from six databases. The Cochrane Risk of Bias tool was used to assessed the quality of these selected original researches. And we used Review Manager 5.3 and STATA to analyze the data.Results: Twenty-two RCTs that matched our selection criteria with a number of 2202 patients were included in our review. The results showed that compared with first-line chemotherapy alone, the combination of ginsenoside Rg3 and first-line chemotherapy could better improve the objective response rate (ORR) (RR [95% CI], 1.44 [1.27, 1.63], p &lt; 0.00001 ), the disease control rate (DCR) (RR [95% CI], 1.24 [1.12, 1.38], p &lt; 0.0001), karnofsky performance status (KPS) (RR [95% CI], 1.62 [1.42, 1.84], p &lt; 0.00001), one-year survival rate (RR [95% CI], 1.49 [1.08, 2.06], p = 0.01), two-year survival rate (RR [95% CI], 6.22 [1.68, 22.95], p = 0.006), weight change (RR [95% CI], 1.31 [1.04, 1.66], p = 0.02), and higher reduce the VEGF levels (RR [95% CI], -2.21 [-4.03, -0.38], p = 0.02), the incidence of gastrointestinal reactions (RR [95% CI], 0.66 [0.47, 0.93], p = 0.02) and bone marrow suppression (RR [95% CI], 0.43 [0.30, 0.61], p &lt; 0.00001).Conclusion: Ginsenoside Rg3 can enhance drug efficacy and reduce drug-induced toxicity from chemotherapy. These findings provide helpful information for clinicians indicating that a therapy combined of ginsenoside Rg3 and first-line chemotherapy may be used to optimal the treatment of advanced NSCLC.
High Expression of Lysophosphatidic Acid Induces Nerve Injury in LSS Patients via AKT Mediated NF-κB p65 Pathway
Authors: Zhai Guiliang , Liang Wenfei , Xu Yongjun 
Published: March 2021

Lumbar spinal stenosis (LSS) is a spinal degenerative disease, complicated with nerve injury. Lysophosphatidic acid (LPA), a kind of glycerophospholipid molecule is elevated in the initial stages of neural injury. This research aimed to investigate the patho-mechanism of nerve injury caused by LPA in LSS patients. Twenty-five LSS patients and fifteen idiopathic scoliosis patients (without neurological symptoms) were recruited from Xianyang Central Hospital of Shanxi Province. We measured the concentration of LPA in cerebrospinal fluid samples of all subjects. Different concentrations (0.1, 1, and 10 mol/L) of LPA were used to stimulate Rat Neurons-spinal cord (RN-SC) cells. The effects of LPA on cell injury was detected by MTT and LDH (lactate dehydrogenase) assay. Cell apoptosis was determined by FCM (flow cytometry) and TUNEL staining. The changes in the expression of key proteins involved in Akt mediated NF-κB p65 pathway intervened by LPA were determined by western blot. RN-SC cells were pretreated with JSH-23 (NF-κB inhibitor) before LPA exposure, followed by cell apoptosis measurement. The concentration of LPA in LSS patients was notably higher than that in control patients (p &lt; 0.01). The level of LPA was positively correlated with the severity of LSS. LPA treatment induced RN-SC cells displaying oval or rounded cell body with degenerated protrusion dose dependently. In addition, LPA decreased RN-SC cell viability and promoted cell apoptosis in a dose-dependent manner. LPA initiated Akt phosphorylation, IKB phosphorylation, and NF-κB nuclear translocation in a dose-dependent manner. However, JSH-23 (NF-κB inhibitor) pre-treatment prevented effects of LPA. The high levels of LPA induced nerve injury by reducing the viability of RN-SC cells and promoted cell apoptosis through Akt mediated NF-κB p65 signaling pathway. LPA might be a new therapeutic target for relieving nerve injury in LSS patients.