bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH SITUASI PASCA KONFLIK SOSIAL TERHADAP PEMBELAJARAN PKn di SEKOLAH
Authors: Tuhuteru Laros 
Published: May 2021

Maluku pasca konflik sosial Masyarakat kini tinggal terkotak-kotak, pada wilaya wilaya tertentu berdasarkan kelompok dan golongan. Namun dalam kehidupan sehari-hari, interaksi antar kelompok sudah berjalan “normal”. Tapi, untuk tinggal berbaur dengan kelompok yang berbeda, masih dirasakan kurang “nyaman”. Kelompok tertentu, yang umumnya bekerja sebagai pedagang, menunggu situasi kondusif. Semua data dan informasi mengenai konflik sosial dikemas melalui sebuah perangkat metode penelitian kualitatif yang menurut peneliti sangat efekif dalam rangka merealisir tujuan penelitian ini. Melalui teknik obsevasi langsung, Disamping itu penulis juga menggunakan metode wawancara mendalam, terutama terhadap beberapa orang informasi kunci yang ditentukan secara sengaja sesuai kebutuhan penelitian ini. Melalui perangkat metode-metode itulah, hasil penelitian ini dapat disajikan melalui penelitian ini. Atas dasar itulah penulis bermaksud membuat analisis secara lengkap dan konprehansif, diantaranya situasi pasca konflik sosial dapat berpengaruh pada pembelajaran PKn di sekolah dan peran masyarakat orang tua atau kelauarga dan berbagai pihak yang berkompeten dalam meberikan pembinaan kepada siswa pasca konflik sosial Maluku. PKn dalam membentuk sikap siswa secara inovatif dalam tujuan dengan formatnya, sehingga para guru merasa keleluasan untuk menentukan pilihan metode pembelajaran PKn benar-benar membina dan membentuk watak sikap karakter siswa yang demokrastis dan bersikap menghargai orang lain dan sadar akan kehidupan bermasyarakat berbangsa dan bernegara. Kata Kunci: Konflik Sosial, Pendidikan Kewarganegaraan.
Impact of Osteonecrosis of Jaw (ONJ) on ten year experience of a multidisciplinary osteoncology team.
Authors: Fusco Vittorio , Fasciolo Antonella , Gallesio Ivan , Alessio Manuela , De Martino Iolanda , Tommasi Luigi , Libener Roberta , Campora Riccardo Alberto , Franzone Paola , Barbanera Andrea , Bellotti Giovanna , Zoccola Kristijan 
Published: May 2021

The Osteonecrosis of the Jaw (ONJ) is a bone disease only recently recognized (since 2003) and reported in association with use of bisphosphonates (BPs), denosumab, and other drugs mostly in patients with cancer, myeloma, and osteoporosis.
Not all clinicians are aware of ONJ epidemiology, risk factors, treatment, preventive measures. On 2005, oncologists and haematologists together with other specialists, nurses and data managers founded a multidisciplinary team for study, treatment and prevention of ONJ at Alessandria Hospital (North-Western Italy).

The work of the group was included since 2010 within a Multidisciplinary Osteoncology Team (Gruppo Interdisciplinare Cure – Osteoncologia) caring patients with cancer and myeloma patients suffering for bone metastases, cord compression, bone-related pain, bone fractures, osteopenia, osteoporosis, and other diseases, together with specialists of other units (Radiotherapy, Orthopaedics, Rheumatology, Physiatry and Rehabilitation, Pain Control Unit, Palliative Care, etc). We report about the activity of the group and demonstration of importance of ONJ disease in the multidisciplinary osteoncology team work burden.
Monitoring Stations for Surface Water Quality
Authors: Wang Qingren , Li Yuncong , Obreza Thomas , Munzo-Carpena Rafael 
Published: May 2021

The traditional approach to water quality monitoring involves manually sampling water at remote sites and transporting it to a laboratory for chemical analysis. New technology and instrumentation have improved our ability to monitor water quality continuously regardless of weather and accessibility. Specialized probes measure water quality parameters, electronic logging devices record and store data, and automatic samplers capture multiple water samples on either time or flow intervals. Telecommunication devices allow data to be downloaded remotely to an office or a laboratory, which makes site monitoring much easier, especially from remote locations. This document is Fact Sheet SL218, a publication of the Soil and Water Science Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Publication date: September 2004.
https://edis.ifas.ufl.edu/ss438
La formación continua de los docentes de educación básica infantil en américa latina: una revisión sistemática
Authors: Aguirre-Canales Vilma I. , Gamarra-Vásquez Julia A. , Lira-Seguín Nelly A. , Carcausto Wilfredo 
Published: May 2021

El propósito principal del presente artículo fue llevar a cabo una revisión sistemática de estudios empíricos sobre la formación continua de docentes en los niveles de educación básica infantil en América Latina, dicha información fue recogida de revistas indexadas en relación al tema en la base de datos de Scielo, Scopus, Ebsco y Dialnet, entre los años 2010 al 2019. De acuerdo al análisis de las evidencias recopiladas, en los diferentes estudios se identificaron aspectos como: a) la formación continua como medio de transformación de la práctica pedagógica, b) el desarrollo profesional docente y la cultura investigativa como parte de la formación continua, c) la importancia del desarrollo de los programas de formación continua para potenciar las capacidades pedagógicas de los docentes. Concluyendo que las publicaciones en relación a la formación continua presentan un carácter ascendente, siendo Brasil el país con el mayor número de publicaciones. Así también, se develó que la metodología más utilizada en estos estudios es de enfoque cualitativo y finalmente se demostró que las aplicaciones de los programas de formación continua tuvieron efectos positivos en la modificación de su trabajo diario como docente y la mejora como profesional.
Sensitivity to Thyroid Hormones and Risk of Prediabetes: A Cross-Sectional Study
Authors: Liu Bingyang , Wang Zixiao , Fu Jinrong , Guan Haixia , Lyu Zhaohui , Wang Wei 
Published: May 2021

ContextThyroid hormone influences glucose homeostasis through central and peripheral regulations. To date, the link between sensitivity to thyroid hormones and prediabetes remains unknown. We aimed to investigate the association between thyroid hormones sensitivity and risk of prediabetes in both general and euthyroid populations.MethodsParticipants with serum free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin (TSH) measurements from the health checkup programs of the First Hospital of China Medical University were collected. We measured the parameters representing central and peripheral sensitivities to thyroid hormones (central sensitivity, assessed by calculating Thyroid Feedback Quantile-based Index (TFQI), TSH Index (TSHI), and Thyrotroph Thyroxine Resistance Index (TT4RI); peripheral sensitivity, evaluated by FT3/FT4 ratio). Associations between thyroid hormones sensitivities and risk of prediabetes were assessed with logistic regression.ResultsA total of 4378 participants (mean age ± SD, 49 ± 11 years) were included, with 1457 (33%) subjects had prediabetes. The risk of prediabetes was negatively associated with levels of TSHI (odds ratio [OR] 0.91; 95% confidence interval [CI], 0.85–0.97), TT4RI (OR 0.91; 95% CI, 0.84–0.99) and Parametric TFQI (PTFQI) (OR 0.89; 95% CI, 0.83–0.95) among all subjects. The association remained significant in euthyroid subjects and euthyroid subjects with negative thyroid autoimmunity. Higher FT3/FT4 ratio was associated with a mild increased risk of prediabetes (95% CI 1.09; 1.02–1.16). Compared with subjects in the lowest quartile of PTFQI, those in the highest quartile had lower risk of prediabetes (0.70; 95% CI, 0.58–0.84).ConclusionsDecreased central sensitivity to thyroid hormones is associated with lower risk of prediabetes. This demonstrates the complex interaction between thyroid system and glucose metabolism. Future studies are warranted to confirm our findings and underlying mechanisms.
The Effects of Tacrolimus on Tissue-Specific, Protein-Level Inflammatory Networks in Vascularized Composite Allotransplantation
Authors: Aral Ali Mubin , Zamora Ruben , Barclay Derek , Yin Jinling , El-Dehaibi Fayten , Erbas Vasil E. , Dong Liwei , Zhang Zhaoxiang , Sahin Huseyin , Gorantla Vijay S. , Vodovotz Yoram 
Published: May 2021

Systems-level insights into inflammatory events after vascularized composite allotransplantation (VCA) are critical to the success of immunomodulatory strategies of these complex procedures. To date, the effects of tacrolimus (TAC) immunosuppression on inflammatory networks in VCA, such as in acute rejection (AR), have not been investigated. We used a systems biology approach to elucidate the effects of tacrolimus on dynamic networks and principal drivers of systemic inflammation in the context of dynamic tissue-specific immune responses following VCA. Lewis (LEW) rat recipients received orthotopic hind limb VCA from fully major histocompatibility complex-mismatched Brown Norway (BN) donors or matched LEW donors. Group 1 (syngeneic controls) received LEW limbs without TAC, and Group 2 (treatment group) received BN limbs with TAC. Time-dependent changes in 27 inflammatory mediators were analyzed in skin, muscle, and peripheral blood using Principal Component Analysis (PCA), Dynamic Bayesian Network (DyBN) inference, and Dynamic Network Analysis (DyNA) to define principal characteristics, central nodes, and putative feedback structures of systemic inflammation. Analyses were repeated on skin + muscle data to construct a “Virtual VCA”, and in skin + muscle + peripheral blood data to construct a “Virtual Animal.” PCA, DyBN, and DyNA results from individual tissues suggested important roles for leptin, VEGF, various chemokines, the NLRP3 inflammasome (IL-1β, IL-18), and IL-6 after TAC treatment. The chemokines MCP-1, MIP-1α; and IP-10 were associated with AR in controls. Statistical analysis suggested that 24/27 inflammatory mediators were altered significantly between control and TAC-treated rats in peripheral blood, skin, and/or muscle over time. “Virtual VCA” and “Virtual Animal” analyses implicated the skin as a key control point of dynamic inflammatory networks, whose connectivity/complexity over time exhibited a U-shaped trajectory and was mirrored in the systemic circulation. Our study defines the effects of TAC on complex spatiotemporal evolution of dynamic inflammation networks in VCA. We also demonstrate the potential utility of computational analyses to elucidate nonlinear, cross-tissue interactions. These approaches may help define precision medicine approaches to better personalize TAC immunosuppression in VCA recipients.
The Effects of LIT and MLR-Bf on Immune Biomarkers and Pregnancy Outcomes in Women With Previous Early Recurrent Miscarriage: A Retrospective Study
Authors: Meng Lili , Tan Jianping , Du Tao , Lin Xianghua , Zhang Shuning , Nie Xiaolu , Xie Haitian , Lin Jizong , Zhang Jianping , Hui Chen 
Published: May 2021

Background: Immunological failure during pregnancy is considered one of the etiologies of recurrent miscarriage (RM). The decreased production of mixed lymphocyte reaction-blocking factors (MLR-Bf) may play a major role in this condition. Lymphocyte immunotherapy (LIT), which induces the production of MLR-Bf, has been used in treating RM patients since 1984. However, the effectiveness of LIT is currently being heatedly debated. In addition to that, possible changes to the maternal immune system upon induced MLR-Bf production by LIT remains unclear.Objectives: To explore the possible impacts that MLR-Bf may have on the expression of immune biomarkers and pregnancy outcomes, and deduce whether the prevention of miscarriages is possible with LIT or MLR-Bf in RM patients.Materials and Methods: Women with previous early RM (eRM) were enrolled in this retrospective study after they got pregnant again. LIT was implemented before pregnancy and during the first trimester. MLR-Bf and immune biomarkers were checked as the clinical routine. Patients were followed up until 12 gestational weeks. Levels of immune biomarkers and successful pregnancy rates were compared between MLR-Bf− group and MLR-Bf+ group stratified by LIT. Independent associations between LIT, or MLR-Bf, and miscarriage were estimated. All data management and analysis were conducted using SPSS 20.0.Results: A total of 1,038 patients, 497 MLR-Bf− (49 cases accepted LIT), and 541 MLR-Bf+(463 cases induced by LIT) were included in the study. Percentage of lymphocytes, the ratio of CD4+ T cells/lymphocytes, and levels of some rheumatoid biomarkers (anti-U1-nRNP, anti-SAA-52kd, and anti-CENOP B) were statistically higher in MLR-Bf+ group than in MLR-Bf− group among women without LIT. With LIT treatment the successful pregnancy rate was statistically higher in MLR-Bf+ group than in MLR-Bf− group (66.7% vs. 51.0%, P = 0.028) among women with LIT. Meanwhile, LIT was estimated to have an independent negative association with miscarriage.Conclusion: Upon LIT treament levels of immune biomarkers were different in women with and without MLR-Bf when stratified by whether they received LIT. Not MLR-Bf, but LIT, has an independent protective effect on miscarriage.
Vasopressin Loading for Refractory Septic Shock: A Preliminary Analysis of a Case Series
Authors: Nakamura Kensuke , Nakano Hidehiko , Naraba Hiromu , Mochizuki Masaki , Takahashi Yuji , Sonoo Tomohiro , Hashimoto Hideki , Abe Toshikazu , Hayakawa Mineji , Yamakawa Kazuma 
Published: May 2021

Background: Vasopressin is one of the strong vasopressor agents associated with ischemic events. Responses to the administration of vasopressin differ among patients with septic shock. Although the administration of a high dose of vasopressin needs to be avoided, the effects of bolus loading have not yet been examined. Since the half-life of vasopressin is longer than that of catecholamines, we hypothesized that vasopressin loading may be effective for predicting responses to its continuous administration.Methods: We retrospectively analyzed consecutive cases of septic shock for which vasopressin was introduced with loading under noradrenaline at &gt;0.2 μg/kg/min during the study period. Vasopressin was administered in a 1 U bolus followed by its continuous administration at 1 U/h. The proportion of patients with a negative catecholamine index (CAI) change 6 h after the introduction of vasopressin was set as the primary outcome. We defined non-responders for exploration as those with a mean arterial pressure change &lt;18 mmHg 1 min after vasopressin loading, among whom none had a change in CAI &lt;0.Results: Twenty-one consecutive cases were examined in the present study, and included 14 responders and 7 non-responders. The primary outcome accounted for 71.4% of responders and 0% of non-responders, with a significant difference (p = 0.0039). Median CAI changes 2, 4, and 6 h after the administration of vasopressin were 0, −5, and −10 in responders and +20, +10, and +10 in non-responders, respectively. CAI was not reduced in any non-responder. Outcomes including mortality were not significantly different between responders and non-responders. Digital ischemia (1/21) and mesenteric ischemia (1/21) were observed.Conclusions: Vasopressin loading may predict responses to its continuous administration in septic shock patients. Further investigations involving a safety analysis are needed.
A Three-Gene Peripheral Blood Potential Diagnosis Signature for Acute Rejection in Renal Transplantation
Authors: Wang Yicun , Zhang Di , Hu Xiaopeng 
Published: May 2021

Background: Acute rejection (AR) remains a major issue that negatively impacts long-term allograft survival in renal transplantation. The current study aims to apply machine learning methods to develop a non-invasive diagnostic test for AR based on gene signature in peripheral blood.Methods: We collected blood gene expression profiles of 251 renal transplant patients with biopsy-proven renal status from three independent cohorts in the Gene Expression Omnibus database. After differential expression analysis and machine learning algorithms, selected biomarkers were applied to the least absolute shrinkage and selection operator (LASSO) logistic regression to construct a diagnostic model in the training cohort. The diagnostic ability of the model was further tested in validation cohorts. Gene set enrichment analysis and immune cell assessment were also conducted for further investigation.Results: A novel diagnostic model based on three genes (TSEN15, CAPRIN1 and PRR34-AS1) was constructed in the training cohort (AUC = 0.968) and successfully verified in the validation cohort (AUC = 0.925) with high accuracy. Moreover, the diagnostic model also showed a promising value in discriminating T cell-mediated rejection (TCMR) (AUC = 0.786). Functional enrichment analysis and immune cell evaluation demonstrated that the AR model was significantly correlated with adaptive immunity, especially T cell subsets and dendritic cells.Conclusion: We identified and validated a novel three-gene diagnostic model with high accuracy for AR in renal transplant patients, and the model also performed well in distinguishing TCMR. The current study provided a promising tool to be used as a precise and cost-effective non-invasive test in clinical practice.
The Time Burden of Specialty Clinic Visits in Persons With Neurologic Disease: A Case for Universal Telemedicine Coverage
Authors: Solomon Daniel L. , Dirlikov Benjamin , Shem Kazuko L. , Elliott Christopher S. 
Published: May 2021

Objective: Those with chronic neurologic disorders are often burdened not only by the condition itself but also an increased need for subspecialty medical care. This may require long distance travel, while even small distances can be a hardship secondary to impaired mobility and transportation. We sought to examine the burden of time associated with clinical visits for those with chronic neurologic disorders and their family/caregivers. These topics are discussed as an argument to support universal coverage for telemedicine in this population.Design: Cohort Study.Setting: Specialty clinic at community hospital.Participants: 208 unique patients with chronic neurologic disability at physical medicine and rehabilitation or neurourology clinic over a 3-month period.Main Outcome Measures: Patient survey on commute distance, time, difficulties, and need for caregiver assistance to attend visits.Results: Approximately 40% of patients were covered by Medicare. Many patients (42%) perceived it difficult to attend their clinic visit with transportation difficulties, commute time, and changes to their daily schedule being the most commonly cited reasons. Most patients (75%) lived within 25 miles of our clinics and experienced an average commute time of 79.4 min, though 10% required 3 h or more. Additional family/caregiver assistance was required for 76% of patients, which resulted in an inclusive average commute time of 138.2 min per patient.Conclusion: Chronically neurologically-disabled patients and their caregivers may be burdened by the commute to outpatient appointments. To minimize this burden, increased emphasis on telemedicine coverage for those with chronic neurologic disability should be considered by all payors.
Magnetic Suppression of Perceptual Accuracy Is Not Reduced in Visual Snow Syndrome
Authors: Eren Ozan E. , Ruscheweyh Ruth , Rauschel Veronika , Eggert Thomas , Schankin Christoph J. , Straube Andreas 
Published: May 2021

Objective: Patients with visual snow syndrome (VSS) suffer from continuous (“TV snow-like”) visual disturbance of unknown pathoetiology. In VSS, changes in cortical excitability in the primary visual cortex and the visual association cortex are discussed, with recent imaging studies tending to point to higher-order visual areas. Migraine, especially migraine with aura, is a common comorbidity. In chronic migraine and episodic migraine with aura but not in episodic migraine without aura, a reduced magnetic suppression of perceptual accuracy (MSPA) reflects a probably reduced inhibition of the primary visual cortex. Here we investigated the inhibition of the primary visual cortex using MSPA in patients with VSS, comparing that with MSPA in controls matched for episodic migraine.Methods: Seventeen patients with VSS were compared to 17 age- and migraine-matched controls. Visual accuracy was assessed by letter recognition and modulated by transcranial magnetic stimulation delivered to the occipital cortex at different intervals with respect to the letter presentation (40, 100, and 190 ms).Results: Suppression of visual accuracy at the 100-ms interval was present without significant differences between VSS patients and age- and migraine-matched controls (percentage of correctly recognized trigrams, control: 46.4 ± 34.3; VSS: 52.5 ± 25.4, p = 0.56).Conclusions: In contrast to migraine with aura, occipital cortex inhibition, as assessed with MSPA, may not be affected in VSS.
Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage
Authors: Jung Hyun Min , Paik Jin Hui , Kim Sin Young , Hong Dae Young 
Published: May 2021

Objectives: Hyperglycemia and hypokalemia are common problems in patients with aneurysmal subarachnoid hemorrhage (aSAH). The aim of this study was to determine whether the plasma glucose to potassium ratio (GPR) predicts mortality due to aSAH.Methods: We prospectively recruited aSAH patients and healthy controls between March 2007 and May 2017. Clinical outcomes included mortality and poor outcome (modified Rankin scale score of 3-6) after 3 months. Multivariable analysis was used to determine the association between plasma GPR and 3-month mortality in aSAH patients.Results: A total of 553 patients were recruited, and the mortality rate was 11%. The GPR was significantly elevated in aSAH patients compared with controls, in patients with a poor outcome than with a good outcome and in non-survivals than in survivals. Multivariable analysis showed that the plasma GPR was an independent factor associated with 3-month mortality. The area under the curve of the GPR was 0.747 in predicting 3-month mortality.Conclusion: The plasma GPR on admission has potential as a predictor of 3-month mortality in patients with aSAH.
Whole-Body MRI vs. PET/CT for the Detection of Bone Metastases in Patients With Prostate Cancer: A Systematic Review and Meta-Analysis
Authors: Zhan Yuefu , Zhang Guangming , Li Mingliang , Zhou Xiaobo 
Published: May 2021

Purpose: A recent meta-analysis in patients with non-small cell lung cancer showed no difference between whole-body magnetic resonance imaging (WBMRI) and positron emission tomography/computed tomography (PET/CT), but no such study is available for prostate cancer (PCa). This study aimed to compare WBMRI and PET/CT for bone metastasis detection in patients with PCa.Materials and Methods: PubMed, Embase, and the Cochrane library were searched for papers published up to April 2020. The population was the patients with untreated prostate cancer diagnosed by WBMRI or PET/CT. The outcomes were the true positive and negative and false positive and negative rates for WBMRI and PET/CT. The summarized sensitivity, specificity, positive likelihood ratios (PLR), negative likelihood ratios (NLR), and diagnostic odds ratios (DOR) were calculated with their 95% confidence intervals (CIs).Results: Four prospective and one retrospective study are included (657 patients). Significant differences are observed between WBMRI and PET/CT for sensitivity (WBMRI/PET/CT: 0.896; 95% CI: 0.813–0.987; P = 0.025) and NLR (WBMRI/PET/CT: 2.38; 95% CI: 1.13–5.01; P = 0.023), but not for specificity (WBMRI/PET/CT: 0.939; 95% CI: 0.855–1.031; P = 0.184) and PLR (WBMRI/PET/CT: 0.42; 95% CI: 0.08–2.22; P = 0.305). WBMRI has a similar a DOR compared with PET/CT (WBMRI/PET/CT: 0.13; 95% CI: 0.02–1.11; P = 0.062). The summary area under the receiver operating characteristic curves for WBMRI is 0.88 (standard error: 0.032) and 0.98 (standard error: 0.013) for PET/CT for diagnosing bone metastases in PCa.Conclusion: PET/CT presents a higher sensitivity and NLR for the bone metastasis detection from PCa, whereas no differences are found for specificity and PLR, compared with WBMRI.