bluuebunny/crossref_metadata_2025_split huggingface dataset:
Humans Use a Temporally Local Code for Vibrotactile Perception
Authors: Bhattacharjee Arindam , Braun Christoph , Schwarz Cornelius 
Published: October 2021

AbstractSensory environments are commonly characterized by specific physical features, which sensory systems might exploit using dedicated processing mechanisms. In the tactile sense, one such characteristic feature is frictional movement, which gives rise to short-lasting (<10 ms), information-carrying integument vibrations. Rather than generic integrative encoding (i.e., averaging or spectral analysis capturing the “intensity” and “best frequency”), the tactile system might benefit from, what we call a “temporally local” coding scheme that instantaneously detects and analyzes shapes of these short-lasting features. Here, by employing analytic psychophysical measurements, we tested whether the prerequisite of temporally local coding exists in the human tactile system. We employed pulsatile skin indentations at the fingertip that allowed us to trade manipulation of local pulse shape against changes in global intensity and frequency, achieved by adding pulses of the same shape. We found that manipulation of local pulse shape has strong effects on psychophysical performance, arguing for the notion that humans implement a temporally local coding scheme for perceptual decisions. As we found distinct differences in performance using different kinematic layouts of pulses, we inquired whether temporally local coding is tuned to a unique kinematic variable. This was not the case, since we observed different preferred kinematic variables in different ranges of pulse shapes. Using an established encoding model for primary afferences and indentation stimuli, we were able to demonstrate that the found kinematic preferences in human performance, may well be explained by the response characteristics of Pacinian corpuscles (PCs), a class of human tactile primary afferents.
DBscorer: An Open-Source Software for Automated Accurate Analysis of Rodent Behavior in Forced Swim Test and Tail Suspension Test
Authors: Nandi Arnab , Virmani Garima , Barve Aatmika , Marathe Swananda 
Published: October 2021

AbstractForced swim test (FST) and tail suspension test (TST) are commonly used behavioral tests for screening antidepressant drugs with a high predictive validity. These tests have also proved useful to assess the non-motor symptoms in the animal models of movement disorders such as Parkinson’s disease and Huntington’s disease. Manual analysis of FST and TST is a time-consuming exercise and has large observer-to-observer variability. Automation of behavioral analysis alleviates these concerns, but there are no easy-to-use open-source tools for such analysis. Here, we describe the development of Depression Behavior Scorer (DBscorer), an open-source program installable on Windows, with an intuitive graphical user interface (GUI), that helps in accurate quantification of immobility behavior in FST and TST from video analysis. Several calibration options allow customization of various parameters to suit the experimental requirements. Apart from the readout of time spent immobile, DBscorer also provides additional data and graphics of immobility/mobility states across time revealing the evolution of behavioral despair over the duration of the test and allows the analysis of additional parameters. Such comprehensive analysis allows a more nuanced understanding of the expression of behavioral despair in FST and TST. We believe that DBscorer would make analysis of behavior in FST and TST unbiased, automated and rapid, and hence prove to be helpful to the wider neuroscience community.
“I’m an artist, but with other tools!”: Le Théâtre Aphasique and the intersection between artistic and clinical practices with people living with aphasia
Authors: Osa Garcia Alberto , D'Anjou Camille , Létourneau Edwards Natasha , François Sandro , Goulet-Simard Pénélope , Marcotte Karine , Gaulin Richard , Côté Isabelle , Verduyckt Ingrid 
Published: October 2021

Theatre has come to be one of the main artistic ways to convey the voices of people with disability to the general audience, and this includes people with language and communication disorders. This article aims to describe and discuss the activities of Le Théâtre Aphasique, a non-profit organization located in several cities in Quebec that delivers dramatic art workshops to people with aphasia, an acquired language disorder. Our interest is to understand how this activity has become a successful phenomenon in different disciplines, with different a priori theoretic frameworks, such as disability arts as well as rehabilitation sciences. Specifically, we suggest that the complexity and means of this activity are indeed the cause of its success given that 1) it allows people with different communication abilities to participate, while 2) encouraging the presence of people with disabilities in the theatrical scene and 3) supporting the understanding and use of different communication styles, from both individual and social perspectives. We believe that a framework built upon social, artistic, and care-driven views of disability can account for the complexity of this activity and nourish further research into how different models of disability are integrated in the experience of people with aphasia.
Job-shop Scheduling Over a Heterogeneous Platform
Authors: Benitez-Perez Hector , Hermosillo-Gomez Jose A. 
Published: October 2021

Real-time scheduling involves determining the allocation of platform resources in such a way tasks can meet their temporal restrictions.
This work focuses on job-shop tasks model in which a task have a finite number of nonpreemptive different instances (jobs) that share a unique hard deadline and their time requirements are known until task arrival.
Non-preemptive scheduling is considered because this characteristic is widely used in industry. Besides job-shop scheduling has direct impacts on the production efficiency and costs of manufacturing systems. So that the development of analysis for tasks with these characteristics is necessary.
The aim of this work is to propose an online scheduling test able to guarantee the execution of a new arriving task, which is generated by human interaction with an embedded system, otherwise to discart it. An extension of the schedulability test proposed by Baruah in 2006 for non-preemptive periodic tasks over an identical platform is presented in this paper. Such extension is applied to non-preemptive tasks that have hard deadlines over a heterogeneous platform. To do that, some virtual changes over both the task set and the platform are effectuated.
Características sociodemográficas e acadêmicas de estudantes de enfermagem em formação profissional
Authors: Saho Mari , Lomanto Georgina Almeida , Salviano Isabel Cristina de Barros , Reis Erenice Santos , Dos Anjos Karla Ferraz , Santa Rosa Darci de Oliveira 
Published: October 2021

OBJETIVO: Descrever as características sociodemográficas e acadêmicas de estudantes de enfermagem de uma instituição de ensino superior sobre sua formação profissional. MÉTODO: Estudo descritivo, quantitativo, realizado com 197 estudantes do curso de graduação em enfermagem, matriculados em todos os períodos do curso. Os dados foram coletados por meio de um questionário fechado autopreenchido e aplicado no período de maio a agosto de 2017. RESULTADOS: Evidenciou-se entre os estudantes de enfermagem o predomínio do sexo feminino (82,2%), solteiros (76,1%), com inserção no mercado de trabalho formal (49,7%), possuem filhos (44,7%), residem distantes da unidade de ensino (69%), utilizam transporte coletivo para deslocar para a IES (82,7%) e faz uso da internet como principal recurso para os estudos (91,4%). Entre as áreas de atuação almejadas durante a formação, tem-se a de assistência e da enfermagem obstétrica. CONCLUSÃO: Verificou-se possíveis contribuições à estruturação do projeto pedagógico do curso, uma vez que o estudo traz elementos que caracterizam o perfil e algumas demandas acadêmicas dos estudantes que frequentam o curso de graduação em enfermagem de uma instituição de ensino.
Editors and Guidelines of the MIMBARDIK Journal, Issue of September 2017
Authors: MIMBARDIK Editor Journal 
Published: October 2021

MIMBAR PENDIDIKAN: Jurnal Indonesia untuk Kajian Pendidikan (Indonesian Journal for Educational Studies) This journal, with ISSN 2527-3868 (print) and 2503-457X (online), was firstly published on March 11, 2016, by UPI (Indonesia University of Education) Press in Bandung and orgnized by the Lecturers of UPI Journal Developer Team. The MIMBAR PENDIDIKAN is a new version journal from the old journal with the similar name that was published since 1995 to 2005. This journal is dedicated not only for Indonesian scholars who concern about educational studies, but also welcome to the scholars of Southeast Asian countries and around the world who care and share related to the educational studies in general. The MIMBAR PENDIDIKAN journal is published twice a year i.e. every March and September. Bandung, Indonesia: September 30, 2017.Prof. Dr. Didi SukyadiEditor-in-Chief of the MIMBAR PENDIDIKAN Journal in Bandung, West Java, Indonesia.
National Curricular Parameters for Mathematics: From the Creation of the Kaleidoscope to the Necessity to Look Back to Move Forward
Authors: Godoy Elenilton Vieira , Britis Karen Gonçalves , Vianna Carlos Roberto 
Published: October 2021

Background: In the last decades in Brazil, the prescriptions of the official curricular documents of school mathematics have been constituted as a practice of successive governments. However, there is still little research on the participation of mathematics teachers and educators in the construction of these prescriptions. Objective: To present the perspective of the research collaborator in the general coordination of the PCNs (National Curriculum Parameters) in the area of Mathematics (3rd and 4th cycles of elementary education). Design: This is a qualitative research, with the production of a documentary source through interviews with thematic oral history procedures. Setting and participants: The research collaborator was professor Dr. Célia Maria Carolino Pires, and the interviews were conducted at her residence. Data collection and analysis: Oral sources were used, in the form of interviews with a researcher in the field of mathematics education, as well as written sources that complemented the necessary information. Results: This article presents a thematic section that, on the one hand, makes public the opinions of a person who actively participated in the elaboration and diffusion of the PCNs; and, on the other hand, it invites us to reflect on how - in the last 50 years in Brazil - primary school teachers have had the opportunity to be supporting/protagonists in terms of curriculum production, and how this production has been conducted and understood as a government policy (and political parties) and not a State policy. Conclusions: The article presents considerations made by a participant engaged in the process of elaborating and disseminating the Mathematics PCNs for the 3rd and 4th cycles of elementary education and - in addition - it was constructed to promote a reflection on more recent themes that include, for example, to think about how external assessments start to induce the production of curricula, functioning as thermometers that supposedly can capture the productivity indices of the school system and, at the same time, promote more symptoms of the illness they intend just to “gauge”
DETECTION OF MINIMAL TUMOR CELLS FOR THE DIAGNOSIS AND TREATMENT MONITORING OF CHILDREN WITH NEUROBLASTOMA
Authors: Shubina I. Zh. , Burlaka N. A. , Kazantsev A. P. , Dolzhikova Yu. I. , Petkevich A. A. , Kirgizov K. I. , Kiselevskiy M. V. 
Published: October 2021

Diagnosis, treatment and designing an adequate strategy of neuroblastoma (NB) therapy in children is still a complicated tasks for pediatric oncology and hematology. One of the key aspects of NB control is detection and monitoring of minimal residual disease.The authors make a concise review of the up-to-date methods, such as immunocytochemistry, fluorescent in situ hybridization (FISH), flow cytometry, the methods of qualitative and quantitative polymerase chain reaction (PCR) to estimate mRNA (RT-PCR and QRT-PCR), which are currently used for minimal residual disease detection in patients with NB. Disialoganglioside GD2, a specific NB marker, is traditionally determined by immunocytochemistry with fluorochromes that enhance its specificity, and by flow cytometry, as well. At present, FISH test is a gold standard for evaluation of the MYCN gen status in NB. A widely used multicolor flow cytometry method allows achieving high specificity of the analysis for NB diagnosis. RT-PCR may search for various targets to reveal NB cells, however, at the moment the only accepted immune target is tyrosine hydroxylase mRNA. Moreover, the studies established that quantitative QRT-PCR has more advantages than traditional qualitative RT-PCR, since this method allows a more accurate and quantitative detection of one or several mRNAs in clinical samples. The review discusses advantages and disadvantages of the main methods currently used for minimal residual disease evaluation of NB cells, such as RT-PCR, flow cytometry, FISH, etc. Comparative studies included multicolor flow cytometry with various combinations of CD9/CD81/CD56/CD45/GD2 monoclonal antibodies, conventional RT-PCR and quantitative QRT-PCR to reveal circulating/disseminated NB cells in the clinical samples of cancer patients and healthy volunteers.The authors analyze the results of various studies that compared accuracy and sensitivity of diagnostic methods such as RT-PCR, flow cytometry, FISH and some others. Despite the advantages of each method, the authors emphasize that multicolor flow cytometry is the optimal approach for the rapid and reliable detection of minimal residual disease and micrometastases of NB.
DEVELOPMENT OF POLYMERIC MICROPARTICLES WITH RADACHLORINE AND ESTIMATION OF THE PROSPECTS OF THEIR USE IN PHOTODYNAMIC THERAPY
Authors: Miroshkina A. M. , Krechetov S. P. , Solovieva N. L. , Krasnyuk I. I. 
Published: October 2021

Introduction. Nowadays, the development of delivery systems based on micro- and nanoparticles is being actively pursued to increase the selectivity and efficiency of photosensitizers in photodynamic therapy. Such microparticles could increase the effectiveness of the already used chemotherapeutic drugs due to their accumulation in the tumor and help to overcome the drug resistance of tumor cells.The aim of this research was to obtain microparticles based on a biocompatible block copolymer of lactic and glycolic acids with the inclusion of the photosensitizer radachlorin, magnetic nanoparticles, and perfluorodecalin and their subsequent evaluation as therapeutic agents for photodynamic therapy.Materials and methods. Microparticles were obtained using the double emulsion method, described using of electron microscopy. Evaluation of their photodynamic properties was carried out using spectrophotometry and MTTtest on cell culture.Results. Spherical microparticles with a size of less than 1 μm were obtained. The release of the active substance from microparticles occurred gradually over two weeks, and in the case of the presence of magnetic nanoparticles, the concentration of radachlorin remained practically unchanged for a month. Exposure of microparticles to the light of LED is accompanied by the formation ofsinglet oxygen. Electron microscopy indicated intracellular position of microparticlesin tumor cells. The MTT test revealed a significant inhibition of cell viability in the presence of microparticles.Conclusion. The research results allow us to consider the obtained biocompatible polymer microparticles with the inclusion of radachlorin as a depot of radachlorin for local use in photodynamic therapy of tumors.
Increasing the medico-economic efficiency of preventive counseling for patients with arterial hypertension and behavioral risk factors for non-communicable diseases
Authors: Zadvornaya O. L. , Pishchita A. N. 
Published: October 2021

Objective:to evaluate behavioral risk factors (BRF) in patients with arterial hypertension (AH) and to determine the ways of improvement of the approaches to preventive consulting targeted to increase medico-economic efficiency of the prevention of cardiovascular diseases (CVDs).Material and methods.A total of 107 patients aged 40–60 years old that attended health-promoting schools for patients with AH at the institutions of primary medical help in Moscow in 2017–2019 were surveyed. The authors used diagnostic criteria of the risk factors for noncommunicable diseases that have behavioral character according to the classification of the World Health Organization (WHO). Along with that, the authors reviewed the opinion of 128 top managers of the institutions of primary medical help that attended the courses of their qualification improvement “Organization of public healthcare” in 2019. The course was dedicated to the possible ways of improvement of preventive consulting of patients with AH and BRF. The methods of content analysis, synthesis, statistical analysis, comparison, etc. were applied. The authors analyzed the documentation on the prevention of CVDs, scientific publications on the subject from eLibrary, Cochrane Library, PubMed, Scopus databases, and official sites of biomedical journals.Results.The sociological survey revealed data on the presence of BRF of non-communicable diseases in patients aged 40–60 years old with verified AH based on scientifically proven criteria and WHO classification. These criteria allowed to evaluate the degree of the proneness of patients with AH to the influence of harmful risk factors (smoking, alcohol consumption, lack of physical activity, unhealthy eating habits) and their combinations. The sociological survey data obtained from the top management of institutions of primary medical help indicated the necessity of the improvement of approaches to group preventive consulting of patients with AH and BRF.Conclusion.The results of the study revealed the main areas of the systemic mistakes in the preventive consulting of patients with AH that have BRF, associated with the evaluation of individual-psychological peculiarities of a personality, and in the organizational aspects of preventive counseling.
Pharmacoeconomic analysis of the application of strong opioids for the treatment of chronic pain syndrome in patients with pancreatic cancer
Authors: Bobrova O. P. , Zyryanov S. K. , Shnayder N. A. , Petrova M. M. 
Published: October 2021

Objective: to evaluate the clinical and economic feasibility of opioid therapy based on the analysis of its cost and effectiveness in patients with chronic pain syndrome in pancreatic cancer.Material and methods. An observational prospective study in parallel groups of patients with chronic pain syndrome associated with pancreatic cancer was carried out. The analysis of cost minimization and cost-effectiveness was applied, as well as pharmacoeconomic modeling, which included the construction of a decision tree in patients receiving morphine sulfate (n=45) and fentanyl TTS (n=45) for pain relief. The sensitivity of the obtained data was assessed using one-way analysis.Results. It was shown that the treatment of chronic pain syndrome in patients with pancreatic cancer with opioid analgesics as part of combined treatment is the least expensive in the morphine sulfate group (incremental cost-effectiveness ratio 144.93). Based on the results of modeling, the prognostic factors of influence on the cost of analgesic therapy were determined: the cost of combined analgesic therapy, the cost of treatment of adverse reactions, and the cost-effectiveness ratio.Conclusion. Analgesic therapy of chronic pain syndrome with morphine sulfate in patients with pancreatic cancer is pharmacoeconomically feasible.
Pharmacoeconomic evaluation of the effectiveness of therapy for metastatic colorectal cancer
Authors: Petukhova Yu. Yu. , Eliseeva E. V. , Volkov M. V. , Li O. N. , Petukhova A. G. 
Published: October 2021

Objective: to perform a pharmacoeconomic evaluation of the effectiveness of therapies for metastatic colorectal cancer (mCRC) based on real practical data on medical help for patients with this disease.Material and methods. The authors performed a comparative cost-effectiveness analysis and the calculation of resource consumption in the application of several options of chemotherapy for mCRC: FOLFOX, FOLFIRI, and FOLFOXIRI; targeted therapy: FOLFOX + bevacizumab, FOLFOX + panitumumab, FOLFIRI + cetuximab, FOLFIRI + aflibercept, regorafenib monotherapy.Results. The cost-effectiveness parameter, calculated as a ratio of the cost of therapy to the median survival without progression, for chemotherapeutic schemes varied from 108 to 167 thousand rubles and for the targeted therapy schemes – from 223 to 930 thousand rubles. The calculation of resource consumption showed that in the case of a limited budget, 100% of patients can be treated by FOLFOX scheme, or 26% of patients by FOLFOX + panitumumab, or 47% of patients by FOLFOX + bevacizumab; and 100% of patients by FOLFIRI scheme or 11.5% of patients by FOLFIRI + cetuximab (aflibercept). Besides, it was established that in the case of a similar budget, 100% of patients with mCRC can be treated by chemotherapy schemes or a limited number of patients with regorafenib.Conclusion. The cost of targeted therapy significantly exceeds the cost of chemotherapeutic schemes. Still, considering the gross domestic product per capita in the Russian Federation, they can be an economically feasible investment and the optimum option of therapy
25 Years of HOW: A Celebration of Language Teaching and Learning
Authors: Sánchez-Solarte Ana Clara 
Published: October 2021

This article overviews the major themes and pedagogical developments that have emerged via the academic endeavors of practitioners and researchers in the last 30 years, while also touching on how my work adheres to these developments. The document starts with a brief historical background on the establishment of HOW as a resource for the academic community.
The next part of the article deals with the theoretical tenets that have influenced my published works. One of those perspectives is the post-method pedagogy, which acknowledges the limitations of attempting to determine what the “best” language teaching method is for everyone, and proposes three parameters to guide language teaching and learning. The next perspective is the psychology of language learning, particularly positive psychology, which is a field that adds balance to the study of negative emotions in the classroom and can be the basis for interventions that aim at enhancing the language learning process. The final construct discussed in the article is metacognition, which refers to how language teachers adapt their mental processes and behaviors to the emerging demands of their context. The article concludes highlighting a number of topics that were relevant three decades ago and that will likely keep their relevance in the future: the complexity of education, the dynamic nature of context and meaning, and the examination of the role of context in the L2 teaching/learning processes, to name only three.