bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of effective disease control of advanced gastric cancer following ramucirumab plus FOLFIRI in second line treatment in clinical practice
Authors: Titova T. A. , Besova N. S. , Artamonova E. A. 
Published: January 2021

Ramucirumab is a human anti-vascular endothelial growth factor receptor 2(VEGFR-2)monoclonal antibodythat acts on vascular endothelial cells to inhibit angiogenesis. Ramucirumab in monotherapy or in combination with paclitaxel or FOLFIRI has proven to prolong overall survival in patients with pretreated metastatic gastric/gastrooesophageal junction adenocarcinoma. In clinical practice combination with ramucirumab showed promising efficacy with median overall survival in 9,6 months and manageable toxicities. Most common specific adverse events in ramucirumab were impaired wound healing, hypertension, bleeding and perforation. In several article describe dysphonia induced by anti-angiogenic compounds.Herein, we report on a case a high activity ramucirumab in combination with FOLFIRI. This report aims to present a long-term survivor of recurrent gastric cancer and describe dysphonia induced by ramucirumab.
Combination of chemoradiation therapy with immunotherapy in the treatment of patients with inoperable stage III non-small cell lung cancer
Authors: Marinichenko N. V. , Laktionov K. K. , Nazarenko A. V. , Reutova E. V. , Ardzinba Merab S. , Utkina V. L. , Borisova T. N. , Fedorova A. A. , Ardzinba Milada S. 
Published: January 2021

For more than 10 years, there have been no significant improvements in treatment outcomes for patients with inoperable locally advanced non-small cell lung cancer. At the moment, the standard of treatment for this category of patients is concurrent chemoradiation therapy. At the same time, the 5-year overall survival rate varies in the range of 15–25%. This indicator contributes to the modernization of existing approaches, as well as the search for new ways in the treatment of patients with inoperable stage III non-small cell lung cancer.One of the promising areas is the combination of chemoradiation therapy with immunotherapy. Thus, the use of Imfinzi (durvalumab, AstraZeneca) as a consolidation therapy in the Phase III clinical trial PACIFIC demonstrated a reduction in the risk of death by about one third in comparison with the standard approach.We present a clinical case study of a patient with locally advanced non-small cell lung cancer who received treatment in the framework of concurrent chemoradiation therapy followed by immunotherapy with durvalumab, continuing until now. The result of the therapy is the complete response to the specific treatment, recorded according to PET-CT.Thus, the use of immunotherapy as consolidation therapy represents a promising strategy for improving outcomes after concurrent chemoradiation therapy in patients with inoperable stage III non-small cell lung cancer
Olaparib in the metastatic HER2-negative breast cancer setting
Authors: Zhukova L. G. , Khatkova E. I. , Ganshina I. P. , Kolyadina I. V. , Lubennikova E. V. 
Published: January 2021

Understanding of cancer biology is at the cornerstone of design of new and effective treatment strategies. Identification of molecular drivers of tumor growth and progression allow identify right patient for the right treatment for personalized treatment plan optimization. Breast cancer (BC) encompasses a heterogeneous collection of neoplasms with diverse morphologies, molecular phenotypes, responses to therapy, probabilities of relapse and overall survival. Molecular and histopathological classification aims to categories tumors into subgroups to inform clinical decisions, to improve long-term treatment results and maintain the quality of life of this group of patients. Germinal mutation in the BRCA1/2 (BRCAm) genes in a tumor determines the hereditary predisposition, disease manifestation, therapeutic options and clinical efficacy. Therefore, patients withBRCAmBCrepresent a special subgroup requiring personalized treatment approach.Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, is a targeted therapeutic agent that acts as inhibitor of single-strand breaks reparation, leading to their accumulation, conversion to double-strand breaks and eventually to cancer cell apoptosis. Olaparib is a first-in-class PARP-inhibitor with an outstanding antineoplastic activity known for some malignant tumors, demonstrates effectiveness and safety of therapy inBRCAmBCas well. The results of OlympiAD and LUCY trials are represented in the article. Subgroup analysis may define the patient population that would benefit from PARP inhibitors therapy.
Еfficiacy and safety of radium-223 in the treatment of metastatic castration-resistant prostate cancer
Authors: Rusakov I. G. , Gritskevich A. A. , Baitman T. P. , Mishugin S. V. 
Published: January 2021

Bone metastases often develop in patients with prostate cancer (PC) as a natural stage in the course of the disease. The skeletal system is the most typical and sometimes even the only site of metastatic prostate cancer. The involvement of bones is a cause of reduced life expectancy and a strong prognostic factor for adverse events, such as bone complications (including the pain requiring surgery or palliative radiation therapy, pathologic fractures and spinal cord compression), resulting in a significant decrease in the quality of life.The model of therapeutic decision-making in metastatic castration-resistant PC (mCRPC) is still an unsolved problem. Several therapeutic options have been developed recently, that has significantly improved the survival of patients with mCRPC. The presence of multiple active agents provides oncologists with an unprecedented opportunity to tailor their choices to the clinical characteristics of each patient and to each line of treatment, but at the same time it creates the challenge of determining the optimal therapeutic sequence for the individual patient.In Russia, radium-223 is approved for patients having bone metastases and no visceral metastases. It can be assigned to patients with lymph node metastases and patients with bulky bone metastases if other drugs are contraindicated to them. However, the use of radium-223 is most preferable if a patient has bone metastases and good bone marrow reserve.Due to the evolution of treatment strategies, the complexity of the process of assessing the dynamics of treatment and the variability of the clinical aspects of the disease, a multidisciplinary approach becomes of great importance today.
Conhecimento das mulheres e dos homens referente ao climatério e menopausa
Authors: Alcântara Laiany Lais de , Nascimento Leila Cristine do , Oliveira Vânia Aparecida da Costa 
Published: January 2021

Objetivo: conhecer o que as mulheres e os homens com vínculo trabalhista ou estudantil da Universidade Federal de São João del-Rei, Campus Centro-Oeste, sabem sobre o climatério e menopausa. Metodologia: estudo de caso único, com abordagem qualitativa e fundamentada na técnica de Análise Crítica do Discurso. A pesquisa contou com 43 participantes, sendo 15 mulheres e 28 homens. Resultados: a distinção entre climatério e menopausa nem sempre é clara para os participantes, sendo desconhecidas, especialmente, pelos participantes do sexo masculino. Além disso, o climatério é um período em que as mulheres queixam-se de vários sintomas, tanto biológicos quanto psicológicos. Considerações finais: há uma defasagem no conhecimento das mulheres referente ao climatério e à menopausa. Nota-se o desconhecimento total dos homens referente ao climatério e poucos sabem o que é a menopausa. Em face ao exposto evidencia-se a necessidade de mais estudos que busquem explorar a temática menopausa/ climatério.
Representações Sociais sobre Esquecimento e Depressão por Pessoas Idosas: Abordagem Processual
Authors: Arreguy-Sena Cristina , Marangon Amanda Maísa Gava , Tosoli Gomes Antônio Marcos , De Melo Laércio Deleon , Martins Renata , Fontes Fabiola Lisboa da Silveira 
Published: January 2021

Objetivo: compreender os conteúdos representacionais e suas origens a partir do esquecimento e da depressão em pessoas com idade ≥ 65 anos, identificando-se as aproximações e as diferenciações atribuídas ao declínio cognitivo. Metodologia: estudo qualitativo delineado na abordagem processual da Teoria das Representações Sociais, realizado numa Unidade de Atenção Primária à Saúde, numa cidade de Minas Gerais, Brasil. Entrevistas individuais em profundidade com gravação de áudio a partir de questões norteadoras. Conteúdos discursivos transcritos na íntegra e tratados em Programa NVivo Pro11, análise de conteúdo. Atendidos todos os aspectos ético-legais de pesquisa. Resultados: foram 49 participantes, cujos fragmentos de discurso permitiram identificar dimensões: comportamental, atitudinal, cognitivo, informativo, valorativo e objetival. A perda cognitiva foi percebida como algo peculiar ao envelhecimento e vinculada à presença da depressão. Conclusão: as representações sociais do esquecimento e depressão foram associadas ao isolamento social com origens vinculadas a problemas (pessoais, sociais ou familiares) identificadas a partir da observação do cotidiano.Descritores: Enfermagem, Envelhecimento, Idoso, Memória, Depressão.Contribuição dos autores: 1) concepção e/ou desenho: Arreguy-Sena e Marangon, 2) análise e interpretação dos dados: Tosoli, de Melo, Martins, Arreguy-Sena, Marangon e Silveira Fortes, 3) redação do artigo: Marangon, Arreguy-Sena, Martins e de Melo, 4) revisão final: Marangon, Arreguy-Sena, Martins e de Melo
Perfil de mulheres acolhidas em leitos de um Centro de Atenção Psicossocial Álcool e Drogas
Authors: Menezes Ferraz Leão Natália , De Andrade Boska Gabriella , De Mattos Cerioni Silva Júlia Carolina , Garcia Claro Heloisa , Ferreira de Oliveira Márcia Aparecida , Rodrigues de Oliveira Mônica Silvia 
Published: January 2021

Objetivo: caracterizar o perfil de mulheres admitidas para uso dos leitos de acolhimento noturno em um Centro de Atenção Psicossocial em Álcool e Drogas (CAPSad) e suas admissões. Metodologia: estudo descritivo, documental e retrospectivo, com abordagem quantitativa. Dados foram coletados de prontuários, seguidos de análise estatística. Resultados: as mulheres tinham em média 38 anos, sem companheiro (81,1%), com vínculo familiar ruim/conflituoso (52,7%), sem vínculo empregatício (83,5%) e em situação de rua (64,5%). As substâncias mais consumidas foram crack e álcool. Frequentemente, as admissões foram por desintoxicação e vulnerabilidade social, com permanência média de 7 dias. Entretanto, 29,1% não concluíram o tratamento e 35,4% retornaram pós-alta buscando atendimento individualizado. Conclusão: o perfil das usuárias relaciona-se com uma relevante vulnerabilidade social, sendo os leitos referência terapêutica para o cuidado integral.
Ações técnicas e gerenciais da enfermagem no Hospital Israelita Albert Einstein para atender na pandemia do COVID-19
Authors: Laselva Claudia Regina 
Published: January 2021

Objetivo: relatar a experiência de liderar a implantação de ações técnicas e assistenciais em hospital para atendimento da pandemia do COVID-19. Método: Relato de Experiência da atuação como gestora na implantação das ações no Hospital Israelita Albert Einstein para atendimento à pandemia do novo coronavírus. Resultados: Foi criado um Comitê de Gestão de Crise multiprofissional que estabeleceu ações como a formação de um Núcleo de Inteligência e um de Epidemiologia, bem como para padronização das boas práticas e uso dos recursos. Conclusão: A participação neste momento de pandemia na experiência de protagonizar ações visando o melhor atendimento foi importante, reafirmando o papel da Enfermagem e do Enfermeiro na gestão na área hospitalar.Descritores: Coronavírus; Infecções por Coronavírus; Pandemias; Enfermagem; Administração hospitalar.TECHNICAL AND MANAGEMENT ACTIONS OF NURSING AT THE ISRAELI HOSPITAL ALBERT EINSTEIN TO ATTEND IN THE PANDEMIC OF COVID-19 Objective: to report the experience of leading the implementation of technical and assistance actions in a hospital to care for the pandemic of COVID-19. Method: Experience report of performance as a manager in the implementation of actions at Hospital Israelita Albert Einstein to attend the pandemic of the new coronavirus. Results: A multiprofessional Crisis Management Committee was created, which established actions such as the formation of an Intelligence Center and an Epidemiology Center, as well as for the standardization of good practices and the use of resources. Conclusion: Participation in this pandemic moment in the experience of leading actions aimed at better care was important, reaffirming the role of Nursing and Nurse in the management in the hospital area.Descriptors: Coronavirus; Coronavirus Infections; Pandemics; Nursing; Hospital Administration. ACCIONES TÉCNICAS Y DE GESTIÓN DE ENFERMERÍA EN EL HOSPITAL ISRAELÍ ALBERT EINSTEIN PARA ASISTIR A LA PANDEMIA DE COVID-19 Objetivo: informar la experiencia de liderar la implementación de acciones técnicas y de asistencia en un hospital para atender la pandemia de COVID-19. Método: Informe de experiencia del desempeño como gerente en la implementación de acciones en el Hospital Israelita Albert Einstein para asistir a la pandemia del nuevo coronavirus. Resultados: se creó un Comité de Gestión de Crisis multiprofesional, que estableció acciones como la formación de un Centro de Inteligencia y un Centro de Epidemiología, así como para la estandarización de buenas prácticas y el uso de recursos. Conclusión: La participación en este momento pandémico en la experiencia de liderar acciones dirigidas a una mejor atención fue importante, reafirmando el papel de Enfermería y Enfermera en la gestión en el área hospitalaria.Descriptores: Coronavirus; Infecciones por Coronavirus; Pandemias; Enfermería; Administración Hospitalaria.
Impacto de um curso de especialização de gestão em saúde no trabalho dos egressos
Authors: Gontijo Tarcísio Laerte , Ferreira Marina Nagata , Moraes Juliano Teixeira , Duarte Sebastião Junior Henrique , Santos Carolina Fernandes 
Published: January 2021

Objetivo: Avaliar o impacto de um curso de especialização em gestão em saúde no trabalho do egresso. Método: Estudo de caso com abordagem quantitativa e qualitativa envolvendo 121 egressos. A coleta de dados ocorreu por meio da aplicação de escala validada e entrevistas semiestruturadas. Foram realizadas análises descritivas e testes de associação de dados quantitativos e análise categorial temática para os qualitativos. Resultados: Foram identificados escores médios entre 4,2 e 4,6, identificando assim o impacto positivo do curso no trabalho dos egressos demonstrado pela melhor sistematização das práticas administrativas e de gestão de pessoas. Conclusões: O curso apresentou impacto positivo no trabalho dos egressos.Descritores: Gestão em saúde; Educação a Distância; Avaliação da saúde.Impact on work of a distance learning health management specialization courseObjective: To evaluate the impact of a specialization course on health management at work of the graduates. Method: Case study with quantitative and qualitative approach involving 121 graduates. Data collection was performed by applying validated scale and semi-structured interviews. Descriptive analysis and association tests of quantitative data and categorical thematic analysis were performed for the qualitative ones. Results: We identified average scores between 4.2 and 4.6, thus identifying the positive impact of the course on the work of graduates demonstrated by better systematization of administrative practices and people management. Conclusions: The course showed a positive impact on the work of graduating students.Descriptors: Health management, Education Distance, Health evalution.Impacto en el trabajo de un curso de especialización en gestión de la salud a distanciaObjetivo: evaluar el impacto de un curso de especialización en la gestión de la salud en el trabajo de los graduados. Método: Estudio de caso con enfoque cuantitativo y cualitativo con 121 graduados. La recolección de datos se realizó mediante la aplicación de escala validada y entrevistas semiestructuradas. Se realizaron análisis descriptivos y pruebas de asociación de datos cuantitativos y análisis temáticos categóricos para los cualitativos. Resultados: Identificamos puntajes promedio entre 4.2 y 4.6, identificando así el impacto positivo del curso en el trabajo de los graduados demostrado por una mejor sistematización de las prácticas administrativas y la gestión de personas. Conclusiones: El curso mostró un impacto positivo en el trabajo de los estudiantes graduados.Descriptores: Gestión de la salud, Educación a distancia, Evaluación en salud.
A insuficiência cardíaca em uma cidade brasileira mineira: um panorama epidemiológico de 10 anos
Authors: Da Costa Pereira Fernanda Ávila , Correia Dayse Mary Da Silva 
Published: January 2021

Objetivos: identificar e analisar os principais desfechos secundários dos pacientes com insuficiência cardíaca, no período de 2009 a 2019, em Juiz de Fora, região da zona mata mineira. Metodologia: estudo epidemiológico a partir de dados coletados de julho a agosto de 2019 no site do Departamento de Informática do Sistema Único de Saúde (DATASUS), de domínio público no Brasil. Foram selecionados como principais desfechos secundários: taxa de hospitalização, mortalidade e custo econômico associado ao tratamento da insuficiência cardíaca. Resultados: no período houve 16.338 internações, 1.280 óbitos e custos com despesas hospitalares que ultrapassaram os 22 milhões de reais. Conclusão: os dados confirmam o impacto da insuficiência cardíaca como uma doença crônica de alta taxa de internação hospitalar, mortalidade e de elevado custo. Descritores: Epidemiologia; Insuficiência Cardíaca; Hospitalização; Mortalidade; Brasil. Objectives: To identify and analyze the main secondary outcomes of heart failure patients from 2009 to 2019 in Juiz de Fora, a Brazilian city of Minas Gerais. Methodology: Epidemiological study from data collected from July to August 2019 on the website of the Department of Informatics of the Unified Health System (DATASUS), in the public domain in Brazil. The main secondary outcomes were selected: hospitalization rate, mortality and economic cost associated with the treatment of heart failure. Results: In the period there were 16,338 hospitalizations, 1,280 deaths and costs with hospital expenses that exceeded 22 million reais. Conclusion: The data confirm the impact of heart failure as a chronic disease with high hospitalization rate, mortality and high cost.Keywords: Epidemiology; Heart Failure; Hospitalization; Mortality; Brazil. Objetivos: Identificar y analizar los principales desfechos secundários dos pacientes con insuficiencia cardíaca en el período de 2009 a 2019 en Juiz de Fora, ciudad brasileña de la región de la zona minera. Metodología: Estudio epidemiológico basado en datos colectados de julio a agosto de 2019 en el sitio del Departamento de Informática del Sistema Único de Salud (DATASUS), del dominio público en Brasil. Se seleccionaron los principales resultados secundarios: tasa de hospitalización, mortalidad y costo económico asociado con el tratamiento de la insuficiencia cardíaca. Resultados: En el período hubo 16.338 hospitalizaciones, 1.280 muertes y costos con gastos hospitalarios que superaron los 22 millones de reales. Conclusión: Los datos confirman el impacto de la insuficiencia cardíaca como una enfermedad crónica con una alta tasa de hospitalización, mortalidad y alto costo.Descriptores: Epidemiologia; Insuficiência Cardíaca; Hospitalização Mortalidade Brasil.
Hydroalcoholic Extract of Solanum lycocarpum A. St. Hil. (Solanaceae) Leaves Improves Alloxan-Induced Diabetes Complications in Mice
Authors: Guimarães Victor Hugo Dantas , Basilio Silva Jéssica Nayara , de Freitas Daniela Fernanda , Filho Otávio Cardoso , da Silveira Luiz Henrique , Marinho Barbhara Mota , de Paula Alfredo Maurício Batista , Melo Geraldo Aclécio , Santos Sérgio Henrique Sousa 
Published: January 2021

Background::
Solanum lycocarpum is a medicinal plant used in Brazil with hypoglycemic
activity by its fruits use. However, the fruits production is restricted in some periods of the
year, differently of leaves.

Objective::
To evaluate the effects of hydroalcoholic extracts of S. lycocarpum leaves in alloxan-induced
diabetic mice.

Methods::
Hydroalcoholic extract of S. lycocarpum was characterized by phytochemical and GCMS
analysis. The Antidiabetic activity was assessed following treatment for 22 days with S. lycocarpum
extract at 125, 250, and 500 mg/kg. Bodyweight, water, and food intake, glycemia, biochemical
parameters, anatomy-histopathology of the pancreas, liver and kidney, and expression of
target genes were analyzed. In addition, oral acute toxicity was evaluated.

Results::
Animals treated showed a significant reduction (p < 0.05) in glycemia following a dose of
125 mg/kg. Food intake remained similar for all groups. Decreased polydipsia symptoms were observed
after treatment with 250 (p < 0.001) and 500 mg/kg (p < 0.01) compared with diabetic control,
although normal rates were observed when 125 mg/kg was administered. A protective effect
was also observed in the pancreas, liver, and kidneys, through the regeneration of the islets. Hypoglycemic
activity can be attributed to myo-inositol, which stimulates insulin secretion, associated
with α-tocopherol, which prevents damage from oxidative stress and apoptosis of β-pancreatic
cells by an increased Catalase (CAT) and Glutathione peroxidase 4 (GPX4) mRNA expression.
The toxicological test demonstrated safe oral use of the extract under the present conditions.

Conclusion::
Hydroalcoholic extract of S. lycocarpum promotes the regulation of diabetes in the
case of moderate glycemic levels, by decreasing glycemia and exerting protective effects on the
islets.
The Effect of Gastric pH on the Pharmacokinetics-pharmacodynamics of Naphthoquine in Rodents, as well as in Human Predicted Using a PBPK Model
Authors: Xie Yuewu , Liu Huixiang , Chen Xiaoyue , Xing Jie 
Published: January 2021

Background:
Fixed-dose combination of artemisinin and naphthoquine (NQ) is a new artemisinin-
based combination therapy for the treatment of uncomplicated Plasmodium falciparum. NQ absorption has
been reported to be affected by food in humans.

Objectives:
The effect of gastric pH on NQ pharmacokinetics and antiplasmodial activity was investigated.

Methods:
The pharmacokinetic profiles of NQ were studied in healthy rodents after an oral dose of NQ with or
without gastric pH modulators, i.e., pentagastrin (stimulator) and famotidine (suppressant). The effect of gastric
pH on NQ exposures in humans was predicted using a physiologically-based pharmacokinetic (PBPK) model.
The effect of gastric pH on the antiplasmodial activity of NQ was evaluated in mice infected with Plasmodium
yoelii.

Results:
Neither pentagastrin nor famotidine affected NQ absorption (AUC0-t and Cmax) significantly (P > 0.05)
in rodents. The predicted PK profiles of NQ in humans did not show an effect of gastric pH. Compared to pure
NQ (ED90, 1.2 mg/kg), the combination with pentagastrin showed non-significantly (< 1.5-fold) higher antimalarial
potency (ED90, 1.1 mg/kg). Correspondingly, the elevation of gastric pH (up to pH 5) by famotidine
treatment resulted in a relatively weaker antimalarial potency for NQ (ED90, 1.4 mg/kg). Such a difference is
within the acceptable range of variability in NQ pharmacokinetics and antiplasmodial activity.

Conclusions:
Although the food was found to significantly impact NQ pharmacokinetics, other factors except
for gastric pH should account for the result, and the warning of careful use of NQ in patients with the acid-related
disease is not expected to be clinically meaningful.