bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large monochromatic components of small diameter
Authors: Carlson Erik , Martin Ryan R. , Peng Bo , Ruszinkó Miklós 
Published: September 2021

AbstractGyárfás conjectured in 2011 that every ‐edge‐colored contains a monochromatic component of bounded (“perhaps three”) diameter on at least vertices. Letzter proved this conjecture with diameter four. In this note we improve the result in the case of : We show that in every 3‐edge‐coloring of either there is a monochromatic component of diameter at most three on at least vertices or every color class is spanning and has diameter at most four.
Socioeconomic and racial/ethnic disparities in receipt of palliative care among patients with metastatic hepatocellular carcinoma
Authors: Alterio Rodrigo E. , Ju Michelle R. , Wang Sam C. , Mansour John C. , Yopp Adam , Porembka Matthew R. 
Published: September 2021

AbstractBackgroundPatients with metastatic hepatocellular carcinoma (HCC) suffer symptoms of both end‐stage liver disease and cancer. Palliative care (PC) enhances the quality of life via symptom control and even improves survival for some cancers. Our study characterized rates of PC utilization among metastatic HCC patients and determined factors associated with PC receipt.MethodsWe conducted a retrospective review of adult National Cancer Database patients diagnosed with metastatic HCC between 2004 and 2016. Chi‐square tests were used to analyze two cohorts: those who received PC and those who did not. Logistic regression was performed to assess the impact of clinicodemographic factors on the likelihood of receiving PC.ResultsPC utilization was low at just 17%. Later year of diagnosis, insured status, and higher education level were associated with an increased likelihood of receiving PC. Treatment at academic centers or integrated network cancer programs increased the likelihood of receiving PC compared to treatment at a community center (odds ratio [OR] = 1.17, 95% confidence interval [CI] = 1.03–1.33 and OR = 1.25, 95% CI = 1.07–1.45; respectively). Hispanics were significantly less likely to received PC than non‐Hispanic Whites (OR = 0.73, 95% CI = 0.64–0.82).ConclusionsPC utilization among patients with metastatic HCC remains low. Targeted efforts should be enacted to increase the delivery of PC in this group.
Balloon dilation of the Eustachian tube with a seeker‐based device: A registry of 169 patients
Authors: Standring Robert T. , O'Malley Ellen M. , Greene Joshua B. , Russell Joseph L. , McCoul Edward D. 
Published: September 2021

AbstractObjectiveTo collect real‐world data on the safety and effectiveness of balloon dilation of the Eustachian tube using a seeker‐based device in patients with persistent/chronic symptoms of Eustachian tube dysfunction.MethodsA multicenter, prospective, single‐arm registry was conducted from June 2018 through August 2020 at 10 US centers, including tertiary care and private practices. Primary endpoints included mean change from baseline in the 7‐item Eustachian Tube Dysfunction Questionnaire (ETDQ‐7) and the serious related adverse event rate. Secondary endpoints include changes in middle ear assessments, surgical intervention rate, and changes in Sino‐Nasal Outcome Test and Work and Activity Impairment (WPAI) questionnaires.ResultsA total of 169 participants were treated with balloon dilation of the Eustachian tube, with 166 and 154 participants completing the 6‐week and 6‐month follow‐ups, respectively. Repeated measures analysis of the change in ETDQ‐7 scores indicated statistically significant improvement (−2.1; 95% CI −2.40, −1.84; P < .0001) at 6‐month follow‐up. The minimum clinically important difference of improvement was achieved by 85% of participants at 6 months. Four nonserious adverse events were reported. Middle ear functional assessments were improved in the majority of participants with abnormal baseline findings. There were no statistically significant differences in the change from baseline ETDQ‐7 scores between participants who had concurrent procedures and those who did not. WPAI scores demonstrated significant improvement.ConclusionReal‐world evidence supports the clinical studies demonstrating that balloon dilation of the Eustachian tube with a seeker‐based device is a safe and effective procedure to treat ETD symptoms.Level of evidence3
Bridging Rigidity and Flexibility: Modulation of Supramolecular Hydrogels by Metal Complexation
Authors: Stach Oliver S. , Breul Katharina , Berač Christian M. , Urschbach Moritz , Seiffert Sebastian , Besenius Pol 
Published: September 2021

AbstractThe combination of complementary, noncovalent interactions is a key principle for the design of multistimuli responsive hydrogels. In this work, an amphiphilic peptide, supramacromolecular hydrogelator which combines metal‐ligand coordination induced gelation and thermoresponsive toughening is reported. Following a modular approach, the incorporation of the triphenylalanine sequence FFF into a structural (C3EG) and a terpyridine‐functionalized (C3Tpy) C3‐symmetric monomer enables their statistical copolymerization into self‐assembled, 1D nanorods in water, as investigated by circular dichroism (CD) spectroscopy and transmission electron microscopy (TEM). In the presence of a terpyridine functionalized telechelic polyethylene glycol (PEG) cross‐linker, complex formation upon addition of different transition metal ions (Fe2+, Zn2+, Ni2+) induces the formation of soft, reversible hydrogels at a solid weight content of 1 wt% as observed by linear shear rheology. The viscoelastic behavior of Fe2+ and Zn2+ cross‐linked hydrogels are basically identical, while the most kinetically inert Ni2+ coordinative bond leads to significantly weaker hydrogels, suggesting that the most dynamic rather than the most thermodynamically stable interaction supports the formation of robust and responsive hydrogel materials.
Wireless power transfer system prototype with a wide input power range rectifier and power‐optimized waveforms
Authors: Benhamou Abderrahim , Tellache Mohamed , Hebib Sami 
Published: September 2021

AbstractThis paper describes a wireless power transfer (WPT) system operating at 2.4 GHz, which is based on waveform optimization technique and a wide input power range rectifier. This latter consists of an RF‐to‐dc power conversion circuit based on circulators. The waveform optimization is then applied in order to enhance the power conversion efficiency at very low input power levels. The proposed WPT system was prototyped and tested in open and closed loop configurations with different types of obstacles placed between the transmitter and the receiver. The generation of power‐optimized waveforms and the control process in the closed loop configuration were carried out using software‐defined radio. The obtained experimental results validate the wide input power behavior of the two proposed WPT systems especially when dealing with very low input power levels and relatively dynamic environments. In fact, for the two WPT systems featured a distance of 1 m and a transmitted power of 50mw, dc power levels of about 38 and 11 μW are harvested in the cases of no obstacle and low attenuation obstacle respectively.
Antinociceptive effects of the combined use of butorphanol and buprenorphine in mice
Authors: Sasaki Kazumasu , Ishikawa Tatsuya , Ikeda Kazutaka , Kasai Shinya 
Published: September 2021

AbstractButorphanol and buprenorphine are mixed opioid receptor agonist‐antagonist drugs widely used as analgesics in people and animals. There are few reports concerning the interaction of multiple opioids, and their antinociceptive effects, when combined with other opioids, remain unclear. Therefore, we report the preliminary findings of the antinociceptive effects of the combined use of butorphanol and buprenorphine in C57BL/6JJcl mice. Both drugs were administered either simultaneously or in different orders. Compared with the baseline values, the tail‐flick and hot‐plate test latencies increased regardless of the order of administration. Furthermore, enhanced latencies were observed on administration of butorphanol followed by buprenorphine. Combined use of these drugs may not attenuate analgesic efficacy. Besides, enhancement of these effects can be obtained by changing the order of the administration of these drugs. It is necessary to further investigate the molecular basis of the underlying mechanism in future definitive studies.
Conservative unconditionally stable decoupled numerical schemes for the Cahn–Hilliard–Navier–Stokes–Darcy–Boussinesq system
Authors: Chen Wenbin , Han Daozhi , Wang Xiaoming , Zhang Yichao 
Published: September 2021

AbstractWe propose two mass and heat energy conservative, unconditionally stable, decoupled numerical algorithms for solving the Cahn–Hilliard–Navier–Stokes–Darcy–Boussinesq system that models thermal convection of two‐phase flows in superposed free flow and porous media. The schemes totally decouple the computation of the Cahn–Hilliard equation, the Darcy equations, the heat equation, the Navier–Stokes equations at each time step, and thus significantly reducing the computational cost. We rigorously show that the schemes are conservative and energy‐law preserving. Numerical results are presented to demonstrate the accuracy and stability of the algorithms.
Non‐invasive prenatal test uptake in socioeconomically disadvantaged neighborhoods
Authors: van der Meij Karuna R. M. , Kooij Caroline , Bekker Mireille N. , Galjaard Robert‐Jan H. , Henneman Lidewij ,   Dutch NIPT Consortium
Published: September 2021

AbstractObjectiveNon‐Invasive Prenatal Testing (NIPT) is increasingly being implemented worldwide. In public health programs, equitable access to healthcare is a fundamental principle which also applies to fetal aneuploidy screening. However, the out‐of‐pocket costs of NIPT may lead to sociodemographic disparities in uptake of screening. This study assessed whether there is a difference in the uptake of NIPT in socioeconomically disadvantaged neighborhoods compared to all other neighborhoods in the Netherlands, where NIPT is implemented in a national screening program (TRIDENT‐2 study).MethodNIPT uptake, postal code and age of 156,562 pregnant women who received pre‐test counselling for prenatal screening in 2018 were retrieved from the national prenatal screening database. Postal codes were used as a proxy to categorize neighborhoods as being either socioeconomically disadvantaged or other. The out‐of‐pocket costs for NIPT were €175.ResultsNIPT uptake in socioeconomically disadvantaged neighborhoods was 20.3% whereas uptake in all other neighborhoods was 47.6% (p < 0.001). The difference in NIPT uptake between socioeconomic disadvantaged neighborhoods and other areas was smaller for the youngest maternal age‐group (≤25 years) compared to other age‐groups.ConclusionThe variation in uptake suggest underlying disparities in NIPT uptake, which undermines the goals of a national fetal aneuploidy screening program of providing reproductive autonomy and equitable access. This has ethical and policy implications for ensuring fair and responsible implementation of fetal aneuploidy screening.
Off‐label drug use in neonates and infants in Spain: A five‐year observational study
Authors: Lizano‐Díez Irene , Kargodorian Joseph , Piñero‐López M. Ángeles , Lastra Cecilia F. , Mariño Eduardo L. , Modamio Pilar 
Published: September 2021

AbstractObjectivesTo provide information about the off‐label rate of all drug prescriptions in neonates and infants up to 1 year in Spain. Also, to analyse the off‐label prescription of medicines under current practice in this age group according to different evidence sources.Study designA five‐year (2015–2019) exploratory observational study about off‐label prescription in neonates and infants (0 to 1 year) at primary health care in Spain. All drug prescriptions in this age group were analysed and classified according to their labelling in off‐label or on‐label. The drugs prescribed off‐label were subsequently reviewed in national formularies and other databases to assess its evidence of use beyond what is recommended in the Summary of Product Characteristics (SmPC).ResultsOn average 34.50% of total prescriptions were prescribed off‐label according to the SmPC. 17.93% of total prescriptions in neonates and infants up to 1 year old were not based on clinical evidence from SmPC, Pediamécum, BNF or DailyMed. In more than 88% of cases, off‐label use was related to the posology section of the SmPC, followed by the therapeutic indications and contraindications sections, in 35.20% and 24.10% of cases, respectively. Almost 13% of off‐label drugs were over‐the‐counter. Salbutamol followed by topical tobramycin and colecalciferol were the drugs most prescribed off‐label.ConclusionsOff‐label use of drugs remains as an important public health concern, especially for neonates and infants up to 1 year, who receive the greatest proportion of off‐label prescriptions. The evidence‐based off‐label prescription is a widespread practice that has shown a stable trend during the 5‐year study period providing also a certain extent of flexibility to paediatricians in some therapeutic decisions.
How is type D personality associated with the major psychological outcomes in noncardiac chest pain patients?
Authors: Roohafza Hamidreza , Bagherieh Sara , Feizi Awat , Khani Azam , Yavari Niloufar , Saneian Parsa , Teimouri Zahra , Sadeghi Masoumeh 
Published: September 2021

AbstractNoncardiac chest pain (NCCP) may lead many problems on the health‐care system. Having type D personality has been shown to adversely affect NCCP patients. This study aimed to determine the psychological comorbidities that type D personality is associated with, in patients with NCCP. The participants of this cross‐sectional study were 360 patients diagnosed with NCCP. Patients filled out questionnaires about sociodemographic, behavioral, and clinical factors (severity of pain, somatization, cardiac anxiety, fear of body sensations, depression, and type D personality). Type D personality was more prevalent among female (p < 0.005), and those people having this personality showed lower sleep quality (p = 0.001) and sexual life satisfaction (p < 0.001) and more likely to be smoker (p < 0.001). Type D personality is strongly associated with fear of body sensations (β = 5.92, SE = 1.95, p = 0.003), pain intensity (β = 3.53, SE = 0.98, p < 0.001), depression (β = 2.91, SE = 0.62, p < 0.001), and somatization (β = 1.75, SE = 0.55, p < 0.001). Type D personality and major psychological comorbidities were strongly associated. Physicians should consider that having type D personality can be linked to NCCP in an effort to help patients receive effective psychological consultations.
Ion transport in polymerized lyotropic liquid crystals containing ionic liquid
Authors: Bandegi Alireza , Kim Kyungtae , Foudazi Reza 
Published: September 2021

AbstractIn this work, we investigate the effect of morphology and segmental dynamics on ion transport in polymerized lyotropic liquid crystals (polyLLCs) containing 1‐butyl‐3‐methylimidazolium tetrafluoroborate as ionic liquid (IL). We demonstrate that two important factors, which affect ion conduction in polyLLCs, are grain size and chain density at the interface. The polyLLC with large grain size (70 nm) shows significant reduction in ion conductivity (one order of magnitude) compared to its homopolymer/IL mixture. However, the polyLLC with small grain size (20 nm) has little difference in ion conductivity compared to its homopolymer/IL mixture. It is observed that decreasing the chain density enhances the interaction of IL with polymer chains and consequently slows the relaxation of polymer chains. In addition, comparing the dynamics of polymer chains in mixtures of homopolymer/IL and templated LLC mesophases shows that the confinement in LLC structure prolongs the relaxation of polymer chains.
Childhood diabetes and sleep
Authors: Monzon Alexandra D. , Patton Susana R. , Koren Dorit 
Published: September 2021

AbstractSleep modulates glucose metabolism, both in healthy states and in disease. Alterations in sleep duration (insufficient and excessive) and obstructive sleep apnea may have reciprocal ties with obesity, insulin resistance and Type 2 diabetes, as demonstrated by emerging evidence in children and adolescents. Type 1 diabetes is also associated with sleep disturbances due to the influence of wide glycemic fluctuations upon sleep architecture, the need to treat nocturnal hypoglycemia, and the need for glucose monitoring and insulin delivery technologies. In this article, we provide an extensive and critical review on published pediatric literature regarding these topics, reviewing both epidemiologic and qualitative data, and provide an overview of the pathophysiology linking sleep with disorders of glucose homeostasis.
High flow nasal cannula versus standard low flow nasal oxygen during flexible bronchoscopy in children: A randomized controlled trial
Authors: Sharluyan Artur , Osona Borja , Frontera Guillem , Brandstrup Kay Boris , Figuerola Joan , Sanz‐Ruiz Isabel , Salas Alberto , Garrido Beatriz , Eva Chocano‐González , Fernandez Andrea , Peña‐Zarza Jose Antonio , Gil Jose Antonio , Bover‐Bauzà Catalina , Sailer Sebastian 
Published: September 2021

AbstractBackgroundHypoxemia is the most frequent complication of fiberoptic bronchoscopy (FB) in children. Guidelines recommend oxygen supplementation and conventional nasal prongs (NC) are used for this purpose. The aim of this study was to evaluate if the use of high‐flow nasal cannula therapy (HFNC) in children undergoing FB result in a lower incidence of hypoxemia than standard oxygen administration.MethodsPatients aged 1 month–16 years undergoing elective FB were included in a prospective randomized controlled, nonblinded, single‐center clinical trial and randomly assigned to receive oxygen via NC or HFNC. Patients’ baseline characteristics were recorded pre‐bronchoscopy. The primary outcome was oxygen desaturation during the procedure defined as saturation less than 94%.ResultsAn intention to treat analysis for 53 patients receiving NC and 51 receiving HFNC, showed HFNC patients were less likely to have hypoxemia than were NC patients (p = .011), with an absolute risk reduction of 0.27 (95% confidence interval [CI]: 0.08–0.45) and a number needed to treat of 3.75 (95% CI: 2.22–12.04). Moderate hypoxemia (SpO2 ≥ 90% and <94%, and <60 s) was observed significantly less often with HFNC than with NC (p = .012). Severe hypoxemia (SpO2 < 90% and >30 s) was not different between groups. Patients undergoing bronchoalveolar lavage (BAL) presented fewer desaturations with HFNC (p = .0003).ConclusionsHFNC offers optimized oxygenation during elective FB with a significant reduction in desaturations and can be considered for oxygen administration, especially when BAL is performed.
Surface modification of nucleopolyhedrovirus with polydopamine to improve its properties
Authors: Yan Guangyao , Wang Hongmei , Lv Jiajing , Li Changyou , Zhang Baohua 
Published: September 2021

AbstractBACKGROUNDBaculoviruses have been developed as promising biopesticides to control pests due to their high host specificity and virulence, and nontoxicity to humans and nontarget animals. However, their sensitivity to ultraviolet (UV) radiation and instability in the natural environment are major constraints to its large‐scale application. In this study, polydopamine‐nucleopolyhedrovirus microcapsules were established to improve the instability of baculoviruses in sunlight.RESULTSThe optimal conditions for the preparation of polydopamine‐nucleopolyhedrovirus microcapsules were as follows:  Spodoptera exigua nucleopolyhedrovirus (SeMNPV)concentration of 2 × 108  polyhedral inclusion body（PIB） mL–1, reaction time of 6 h, and pH of 9.0. The particle size of the obtained microcapsules was about 1 μm. The microencapsulated baculovirus improved its thermal stability and wettability, and enhanced its insecticidal activity against Spodoptera exigua. Moreover, under the same UV treatment, the insecticidal effect against S. exigua larvae of microencapsulated baculovirus was only reduced by 8.89%, whereas that of the nonmicroencapsulated baculovirus was reduced by 27.27%.CONCLUSIONPolydopamine‐nucleopolyhedrovirus microcapsules provided better UV resistance and preparation stability compared with unmodified SeMNPV, and demonstrate an idea for the development of a baculovirus‐based stabilized product. © 2021 Society of Chemical Industry.
Efficient GLM‐based control charts for Poisson processes
Authors: Mahmood Tahir , Iqbal Anam , Abbasi Saddam Akber , Amin Muhammad 
Published: September 2021

AbstractThe control charts are essential instruments that can impart crucial insights to quality controllers for maintaining the productivity of manufacturing processes. The conventional charting designs are based on a single study variable without exerting auxiliary information. Control charts derived from simple linear regression, generally with normality assumption, are one straightforward way of overcoming this difficulty. But, for a count distributed process, the generalized linear model (GLM) based strategy yields better outcomes. Hence, this study presents GLM‐based progressive mean (PM) and double progressive mean (DPM) charting structures by employing the standardized residuals of the Poisson regression model. The functioning of the suggested and existing schemes (i.e., SR‐EWMA) is investigated in the matter of run length distributions. The comparative analysis demonstrated that PM structures based on standardized residuals (i.e., SR‐PM and SR‐DPM) outperform the existing counterpart (i.e., SR‐EWMA). Specifically, the SR‐DPM chart is found to be more productive in identifying increasing alterations in the process mean. Finally, a case study about a 3D manufacturing procedure is presented to accentuate the significance of the suggested methods.