bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanistic Understanding of the Impact of EOR Polymer on the Inhibition Mechanism and Performance of Phosphonate Scale Inhibitors
Authors: Beteta Alan , Boak Lorraine , McIver Katherine , Jordan Myles , Shields Robin 
Published: November 2021

Abstract
With the current trend for application of Enhanced Oil Recovery (EOR) technologies, there has been much research into the possible upsets to production, from the nature of the produced fluids to changes in the scaling regime. The key question being addressed in this publication is the influence of EOR chemicals, such as hydrolyzed polyacrylamide (HPAM), on scale inhibitor (SI) squeeze lifetime for barium sulphate and calcium carbonate scale risk. Squeeze lifetime is defined as the duration of time (or produced water volume) before the minimum inhibitor concentration (MIC) is reached. This is controlled by the adsorption, and later release, of the inhibitor onto the reservoir rock and the MIC of the inhibitor selected for the produced brine. This paper builds on earlier published work investigating potential changes to inhibitor adsorption caused by polymer EOR produced and moves to the evaluation of the changes in MIC due to the presence of EOR chemical.
In the static inhibitor performance bottle tests, the EOR polymer alone appeared to show some degree of inhibition performance against BaSO4, but below a level required for effective scale management. However, in combination with the inhibitor (DETPMP) at near MIC levels, the inhibition efficiency was negatively impacted by the presence of degraded HPAM EOR polymer. During dynamic tube blocking tests, the inclusion of even low levels of HPAM (2.5 ppm) were shown to reduce the differential pressure build up suggesting barite scale inhibition or reduced adhesion to the coil. Furthermore, the scale morphology produced in these tests, examined under a scanning electron microscope, was clearly impacted in the presence of HPAM. For the CaCO3 system there appears to be increasing positive impact from HPAM on CaCO3 morphology with HPAM concentration and, as observed for BaSO4, an improved performance in dynamic efficiency experiments. However, at higher HPAM concentrations (500 ppm) the precipitate was amorphous and only a minor pressure rise was observed during the tube blocking experiments.
From these observations, it is clear that HPAM can impact the way both calcite and barite scale grow, especially at lower inhibitor concentrations (&lt;MIC) and hence impacts the mechanism by which DETPMP can function to prevent scale nucleation and growth.
This study represents a comprehensive review of both inhibition performance in the presence of an EOR polymer and with these findings the implication to field treatment lifetimes and associated costs of scale management via scale squeeze in a field under HPAM flooding.
Dolomite Stimulation with Retarded Acids
Authors: Daeffler Christopher , Fernandez del Valle Julia , Elkhoury Jean , Panga Mohan , Nikolaev Max , Kamaletdinov Bulat 
Published: November 2021

Abstract
Globally, dolomite formations are important reservoirs for oil and gas. Acid stimulation is commonly used to extend the life of carbonate reservoirs, and a good understanding of the fluid performance is essential for effective treatment design. Three acids, hydrochloric acid (HCl), emulsified HCl, and a single-phase retarded acid based on HCl, were assessed for their ability to create wormholes in Silurian dolomite under laboratory conditions using a standard core flow experiment. Select cores were imaged by X-ray computed tomography to visualize the wormhole morphology. Similar experiments in Indiana limestone was used as a control. The core flow experiments showed that the pore volume to break-through (PVbt) values for the retarded acids in Indiana limestone were less sensitive to changes in temperature overall than unmodified HCl. For Silurian dolomite though, the opposite is observed. HCl has uniformly high PVbt values at lower (200 °F) and higher (325 °F). The emulsified acid and the single-phase retarded acid are more efficient than HCl, but the difference is smaller at 325 °F. Core images revealed that all three fluids had some degree of wormhole branching at 200 °F and much less branching at 325 °F. By visual inspection, the single-phase retarded acid has less ramification than HCl and the emulsified acid. Overall, the results show that retarded acids should make effective stimulation fluids for dolomite reservoirs.
Acceptance of Disability, Coping Style, Perceived Social Support and Quality of Life Among Patients With Chronic Lymphedema: a Cross-sectional Study
Authors: Huang Zehao , Wu Siyu 
Published: November 2021

Abstract
Objective: To examine acceptance of disability, coping style, perceived social support, and quality of life and to explore the relationships between acceptance of disability, coping style, perceived social support and quality of life among Chinese patients with chronic lymphedema.Methods: Chronic lymphedema patients were recruited from five tertiary hospitals between May and July 2020 in China. Recruited patients were assessed for quality of life (QOL), acceptance of disability (AOD), coping styles, perceived social support (PSS), and sociodemographic and disease-related factors. Multivariate linear regression models were conducted to examine the multivariate effect of AOD, coping style, PSS, and sociodemographic and disease-related factors on QOL.Results: A total of 163 chronic lymphedema patients were recruited. The mean score of QOL was 2.23 (SD=0.68). AOD, number of symptoms, acceptance-resignation, avoidance, degree of pain, PSS, and educational level were found to be significant predictors of QOL.Conclusion: Chinese patients with chronic lymphedema had moderate levels of QOL. The QOL and specific domains of patients were affected by different factors. Special attention and targeted interventions should be given to improve patients’ QOL.
An Ethno Botanical Study of Medicinal Plants Used for Respiratory Tract Disorders in Northern Parts of Palestine
Authors: Shawarb Nuha , Badrasawi Manal , Qaoud Hassan Abu , Hussein Fatima 
Published: November 2021

Abstract
Background: There are many medicinal applications of natural plant remedies. Several illnesses are still being treated by Palestinian people using medicinal plants. This research was intended to study the use of natural plants to treat different types of Respiratory tract disorders. Method: In the Northern part of Palestine, an ethno-pharmacological study of medicinal plants used to treat respiratory diseases has been carried out. A questionnaire was circulated to 120 informants. The details gathered included the names of the plants, the parts used, the diseases for which the products were used, as well as the method of preparation. To evaluate results: percentages (%), Fic (factor of informant consensus) and FL (fidelity-level) was calculated. Results: A total of 120 participants were included in the final analysis. The highest percentage of herbal use was reported for flu (103 participants) followed by cough, while the lowest percentages of users were in bronchitis management. The study showed that 31 plant species of 19 families were used for respiratory disorders. 6 species are from Lamiaceae family, while 3 species from Apiaceae family, two species are from Amaryllidaceae, Fabaceae, Myrtaceae, Rutaceae and Zingiberaceae , while the rest of the families only one species was mentioned by the participants, The pieces used most commonly were leaves and fruits. Decoction was the technique of preparation and was taken as a hot drink.Chamomile, mint, sage , lemon and ginger all were in treatment of all of the five respiratory diseases.Conclusions: The information provided on medicinal plants, with maximum percents & FL values can serve as basic data for further research to identify the active biological ingredients in these plants., and to develop new drug preparations for the treatment of disorders of the resapiratory system.
Omitting the First Step of GLIM Framework Yielded Better Accordance With PG-SGA in Chinese Ambulatory Cancer Patients: a Prospective Cross-sectional Study
Authors: Wang Yanfei , Liu Ziqi , Wang yunyi , Chen Xiaoyan , Liu Zhongfen , Zheng Yanqun , Jiang Danfeng , Xia Lina , Fang Yu , Peng Zhi , Liu Wei 
Published: November 2021

Abstract
Background and Aims: The Global Leadership Initiative on Malnutrition (GLIM) criteria is a new framework for diagnosing malnutrition in combination of phenotypic and etiologic criteria after nutrition screening using validated screening tools. The aim of this study was to evaluate the efficacy of malnutrition screening tool (MST), malnutrition universal screening tool (MUST) and nutritional risk screening 2002 (NRS2002) as the first step of GLIM framework in comparison to Patients-Generated Subjective Global Assessment (PG-SGA) in Chinese ambulatory cancer patients.Methods: A single-center prospective cross-sectional study was conducted. Nutritional screening and assessment were performed within 4h after admission to the hospital using a structured questionnaire including MST, MUST, NRS2002, PG-SGA and GLIM, with supplement information of calf circumference (CC) measurement and body composition measurement using bioelectrical impedance analysis (BIA). Malnutrition diagnosis made by GLIM framework using MST, MUST or NRS2002 as the first step or without screening step were compared to PG-SGA separately. Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values and κ values were used to evaluate performance of the screening tools.Results: Of the 562 included patients, Of the participants 62.8% (355/562) were male and 37.2% (210/562) were female, with a male to female radio of 1.69:1. The median age of the patients was 59.0 years (range, 21-82y; interquels range 52.0-65.0y). From the 562 patients included in the study, 41.8% of patients were evaluated as malnutrition (PG-SGA≥4) and 11.9% were diagnosed as severe malnutrition (PG-SGA D). For GLIM criteria, omitting the screening step yielded fair accordance with PG-SGA in diagnosing malnutrition (κ=0.623) and severe malnutrition (κ=0.515). Using MUST as the first step of GLIM framework has better performance (κ=0.614; κ=0.515) than using MST (κ=0.504, κ=0.496) or NRS2002 (κ=0.363, κ=0.503) as the screening tool regardless of severity gradings.Conclusions: Using PG-SGA as the standard, GLIM framework omitting first step has better performance compared with using MST, MUST or NRS2002 as the screening tool. Among the screening tools validated to be used in the first step of GLIM framework, MUST may be the better choice for ambulatory cancer patients.
FLOT; To Be Treated as a Highly Emetogenic Regimen or a Moderately Emetogenic One? Comparison of the Emetogenic Potential of FLOT versus FOLFOX and TAC Regimens
Authors: Ghorbani Marziyeh , Dehghani Mehdi , Fahimfar Noushin , Namazi Soha , Dehshahri Ali 
Published: November 2021

Abstract
PurposeThe current study aimed at investigating the efficacy of aprepitant-containing triple antiemetic regimen in FLOT (Fluorouracil+Leucovorin+Oxaliplatin+Docetaxel) recipients as well as the emetogenic potential of FLOT regimen, through comparison of nausea and vomiting rates in a moderately emetogenic chemotherapy, FLOT, and a highly emetogenic chemotherapy recipients.StudyPatients planned to receive one of FLOT, FOLFOX (Fluorouracil+Leucovorin+ Oxaliplatin/moderate-emetic-risk), or TAC (Docetaxel+Doxorubicin+Cyclophosphamide/high-emetic-risk) regimens were recruited. All patients were treated with the same triple antiemetic regimen containing aprepitant.ResultsA total of 165 chemotherapy-naïve patients (52 FLOT recipients) were eligible to enter the study. At the end of day five, “complete response” (primary efficacy endpoint) was achieved by 84.6%, 63.5%, and 61.5% of the FLOT-receiving patients in acute, delayed, and overall phases, respectively. A significant difference was seen among the odds of FLOT recipients and FOLFOX recipients concerning “complete response” achievement in delayed (p=0.014) and overall (p=0.017) phases, “no emesis” in delayed (p=0.018) and overall (p=0.010) phases, also “complete protection” in acute (p=0.023), delayed (p=0.009) and overall (p=0.006) phases; however, the difference between the odds of FLOT recipients and TAC recipients, in relation to achieving these endpoints was insignificant. FLOT group showed significantly faster time-to-antiemetic regimen failure and time-to-first emetic episode in comparison to the FOLFOX group, which was insignificant in comparison to the TAC group.ConclusionAccording to the findings, FLOT has to be considered as a high-emetic-risk regimen. To better management of highly emetogenic regimens, antiemetic guidelines recommend adding olanzapine to aprepitant-containing triple antiemetic regimen besides continuing dexamethasone and olanzapine administration on days 2-4.
Moderate-intensity interval training (MIT) can protect rats against Methamphetamine –induced injuries
Authors: Bafti Ahad Shafiei , Haghighi Amir Hossein , Askari Roya , Keyhani Alireza , Zadeh Mahla sadat Nabavi , Asadi-Shekaari Majid 
Published: November 2021

Abstract
Methamphetamine (METH) can cause neurotoxicity and increase the risk of neurodegenerative disorders such as Alzheimer disease and Parkinson disease. This study aimed to investigate the effect of moderate-intensity interval training (MIT) on gene expression and antioxidant status of the hippocampus of METH-dependent rats. Twenty-eight male Wistar rats were randomly divided into four equal groups (n=7): saline, METH, MIT, and METH+MIT. METH was injected intraperitoneally at 5 mg/kg for 21 days. The MIT (intermittent running) was performed on the treadmill 5 days a week for 8 weeks. Morris Water Maze test was performed to measure learning and memory. Then, the hippocampal tissue was extracted to evaluate changes in gene expression and biochemical enzymes. The data were analyzed using one-way and two-way ANOVA methods at P<0.05. The results showed that METH injection significantly reduced spatial memory and antioxidant enzymes and increased the expression of α-synuclein (α-syn), cyclin-dependent kinase 5 (CDK5), tau and phosphorylated tau (p-Tau) genes compared to the saline group. MIT significantly increased spatial memory and antioxidant enzymes. However, it reduced α-syn, CDK5, tau and p-tau expression. Thus, METH caused neural damage, and MIT could protect the neural system against METH-induced insults in male rats.
HGCSG1902 Multicenter, Prospective, Observational Study of Chemotherapy-induced Dysgeusia in Gastrointestinal Cancer
Authors: Ito Ken , Yuki Satoshi , Nakatsumi Hiroshi , Kawamoto Yasuyuki , Harada Kazuaki , Nakano Shintaro , Saito Rika , Ando Takayuki , Sawada Kentaro , Yagisawa Masataka , Ishiguro Atsushi , Dazai Masayoshi , Iwanaga Ichiro , Hatanaka Kazuteru , Sato Atsushi , Matsumoto Ryusuke , Shindo Yoshiaki , Tateyama Miki , Muranaka Tetsuhito , Katagiri Masaki , Yokota Isao , Sakata Yuh , Sakamoto Naoya , Komatsu Yoshito 
Published: November 2021

Abstract
PurposeDysgeusia is an adverse event caused by chemotherapy. Although retrospective studies have shown zinc administration improves dysgeusia, there have been no prospective studies. The present study examined effects of zinc therapy on dysgeusia in patients with gastrointestinal cancer.MethodsThis multicenter, prospective, observational study enrolled patients with dysgeusia during chemotherapy treatment. Patients received treatment of no intervention (control), polaprezinc p.o., or zinc acetate hydrate p.o. and serum zinc levels were measured at 0 (baseline), 6, and 12 weeks. Dysgeusia was assessed using CTCAE v5.0 and Subjective Total Taste Acuity (STTA) criteria using questionnaires at baseline and 12 weeks.ResultsFrom February 2020 to June 2021, 180 patients were enrolled from 17 institutes. There were no differences in mean serum zinc levels in each group at baseline (67.3, 66.6, and 67.5 μg/dL in the no intervention, polaprezinc, and zinc acetate hydrate groups, respectively. P = 0.846) and the mean changes in serum zinc level in the three groups from baseline to after 12 weeks were −3.8, +14.3, and +46.6 μg/dl, respectively. The efficiency rates of dysgeusia were 33.3%, 36.8%, and 34.6% using CTCAE and 33.3%, 52.6%, 32.7% using STTA in the no intervention, polaprezinc, and zinc acetate hydrate groups, respectively. The polaprezinc group showed a significantly improved STTA score compared with the no intervention group (P = 0.045).ConclusionThere was no significant correlation between the degree of serum zinc elevation and improvement in dysgeusia, suggesting that polaprezinc, but not zinc acetate hydrate, is effective in improving chemotherapy-induced dysgeusia.Trial registration number UMIN000039653. Date of registration, March 2, 2020.
ELIoT: Enhancing LiFi for a Next Generation Internet of Things
Authors: Linnartz Jean Paul , Corrêa Carina Ribeiro Barbio , Cunha Thiago Elias Bitencourt , Tangdiongga Eduward , Koonen Ton , Deng Xiong , Wendt Matthias , Abbo Anteneh A. , Stobbelaar Pieter J. , Polak Piotr , Müller Marcel , Behnke Daniel , Martinez Marcos , Vicent Santiago , Metin Taner , Emmelmann Marc , Kouhini Sepideh , Bober Kai Lennert , Kottke Christoph , Jungnickel Volker 
Published: November 2021

Abstract
Communication for the Internet of Things (IoT) currently is predominantly narrowband and cannot always guarantee low latency and high reliability. Future IoT applications such as flexible manufacturing, augmented reality and self-driving vehicles rely on sophisticated real-time processing in the cloud to which mobile IoT devices are connected. High-capacity links that meet the requirements of the upcoming 6G systems cannot easily be provided by the current radio-based communication infrastructure. Light communication, which is also denoted as LiFi, offers huge amounts of spectrum, extra security and low-latency transmission free of interference even in dense reuse settings. We present the current state-of-the-art of LiFi systems and introduce new features needed for future IoT applications. We discuss results from a distributed multiple-input multiple-output topology with a fronthaul using plastic optical fiber. We evaluate seamless mobility between the light access points and also handovers to 5G, besides low power transmission and integrated positioning. Future LiFi development, implementation and efforts towards standardization are addressed in the EU ELIoT project which is presented here.
The Potential Influence Factors To Dengue Epidemic Changes In Different Countries During COVID-19 Pandemic
Authors: Fan Bo , Kang Tianhui , Wang Peigang , Sheng Ziyang , An Jing 
Published: November 2021

Abstract
Background During the swooped coronavirus pandemic in 2020, the non-pharmaceutical interventions (NPIs) not only controlled the pandemic of coronavirus, but also had impacts on other infectious diseases. Dengue has become a disease that calls for key detection with it spreading rapidly worldwide in recent years. This study aims to discuss the impacts of the potential influence factors on dengue during the coronavirus according to the data of dengue pandemic of different countries around the world. Methods We collected the data of 2019 and 2020 dengue cases from 57 countries around the globe. Through correlation analysis and rank sum analysis, we sought to discuss the potential effects of different factors during the outbreak of COVID-19 on dengue. Results The results showed that dengue case subtractions had a significant correlation with the territorial area, the suffered and the deceased number of COVID-19 cases. Further rank sum analysis indicated that there is a significant difference in the number of dengue fever cases between the two years, countries with different continental locations, 2019 and 2020 GDPs per capita, the gaps between two years, territory areas, populations and coronavirus occurrences. Conclusions The results altogether showed that the coronavirus pandemic affected dengue epidemic on a certain degree. Considering the epidemic of dengue is closely related to national economy, geography and demography, our results also further indicated that individual measures should be taken to suppress the development of dengue in different countries depending on their own circumstances, especially during major health events.
Long-Term Carbon Accumulation in Temperate Swamp Soils: A Case Study from Greenock Swamp, Ontario, Canada
Authors: Dazé Emily , Byun Eunji , Finkelstein Sarah A 
Published: November 2021

Abstract
Wetlands that develop peat are a globally significant pool of soil carbon. While some wetland types such as bogs and fens are well characterized by the consistent development of carbon-rich peat, swamps soils are more variable both in terms of their carbon densities and accretion rates. Subcategorizing swamps by forest type may be a useful way of understanding this variability. Here we provide a case study of carbon accumulation in two distinct forest stands of Greenock Swamp located in the Great Lakes – St Lawrence mixed forest region in Bruce County, Ontario, Canada: an Acer - Fraxinus (maple-ash) dominant stand (i.e., broad-leaved swamp) and a Thuja occidentalis (cedar) dominant stand (i.e., needle-leaved swamp). Organic matter and organic carbon contents were analyzed among seven Acer - Fraxinus soil cores and one Thuja occidentalis core collected from Greenock Swamp. The Acer - Fraxinus cores had peat depths ranging from 18-60 cm with a mean organic matter content of 54% and an organic carbon content of 34% of dry mass. The Thuja occidentalis swamp core had at least 4 m of almost homogeneous peat with a mean organic matter content of 89%. Radiocarbon dating indicates that the Acer - Fraxinus swamp accumulates peat episodically whereas the Thuja occidentalis swamp showed continuous peat accumulation since the Middle Holocene. Overall, both broad-leaved and needle-leaved swamps have important soil carbon stocks, and are prevalent wetland types in middle latitudes. Both need to be considered to fully represent the carbon pools and potential sink of temperate wetlands.
Empirical Assessment of Alternative Methods for Identifying Seasonality in Observational Healthcare Data
Authors: Molinaro Anthony , DeFalco Frank 
Published: November 2021

Abstract
BackgroundSeasonality classification is a well-known and important part of time series analysis. Understanding the seasonality of a biological event can contribute to an improved understanding of its causes and help guide appropriate responses. Observational data, however, are not comprised of biological events, but timestamped diagnosis codes the combination of which (along with additional requirements) are used as proxies for biological events. As there exist different methods for determining the seasonality of a time series, it is necessary to know if these methods exhibit concordance. In this study we seek to determine the concordance of these methods by applying them to time series derived from diagnosis codes in observational data. Methods: We compared 8 methods for determining the seasonality of a time series at three levels of significance (0.01, 0.05, and 0.1), against 10 observational health databases. We evaluated 61,467 time series at each level of significance, totaling 184,401 evaluations. Results: Methods of binary seasonality classification when applied to time series derived from diagnosis codes in observational health data produce inconsistent results. Across all databases and levels of significance, concordance ranged from 20.2% to 40.2%.Conclusion: The results indicate that researchers relying on automated methods to assess the seasonality of time series derived from diagnosis codes in observational data should be aware that the methods are not interchangeable. Seasonality determination is highly dependent on the method chosen.