bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vorschlag zur Reform der Pflegeversicherung – Funktioniert die Soziale Marktwirtschaft noch?
Authors: Fetzer Stefan , Hagist Christian 
Published: February 2021

ZusammenfassungAm 11.11.2020 veröffentliche Jens Spahn das Eckpunktepapier zur Reform der sozialen Pflegeversicherung. Die Autoren beleuchten die ordnungs- und verteilungspolitischen Implikationen vier zentraler Aspekte des Reformvorschlags: das Einfrieren des maximalen Eigenanteils bei der stationären Versorgung; die Verpflichtung der Länder, sich an den Investitionskosten der Pflegeheime zu beteiligen; den Einstieg in einen Steuerzuschuss zur Pflegeversicherung und den Ausbau der Kapitalfundierung in der Finanzierung zukünftiger Leistungsversprechen. Trotz Reformvorschlag bleiben aber weiterhin wichtige Fragen unbeantwortet.
Mapping tumour heterogeneity with pulsed 3D CEST MRI in non-enhancing glioma at 3 T
Authors: Warnert Esther A. H. , Wood Tobias C. , Incekara Fatih , Barker Gareth J. , Vincent Arnaud J. P. , Schouten Joost , Kros Johan M. , van den Bent Martin , Smits Marion , Tamames Juan A. Hernandez 
Published: February 2021

Abstract
Objective
Amide proton transfer (APT) weighted chemical exchange saturation transfer (CEST) imaging is increasingly used to investigate high-grade, enhancing brain tumours. Non-enhancing glioma is currently less studied, but shows heterogeneous pathophysiology with subtypes having equally poor prognosis as enhancing glioma. Here, we investigate the use of CEST MRI to best differentiate non-enhancing glioma from healthy tissue and image tumour heterogeneity.

Materials & Methods
A 3D pulsed CEST sequence was applied at 3 Tesla with whole tumour coverage and 31 off-resonance frequencies (+6 to -6 ppm) in 18 patients with non-enhancing glioma. Magnetisation transfer ratio asymmetry (MTRasym) and Lorentzian difference (LD) maps at 3.5 ppm were compared for differentiation of tumour versus normal appearing white matter. Heterogeneity was mapped by calculating volume percentages of the tumour showing hyperintense APT-weighted signal.

Results
LDamide gave greater effect sizes than MTRasym to differentiate non-enhancing glioma from normal appearing white matter. On average, 17.9 % ± 13.3 % (min–max: 2.4 %–54.5 %) of the tumour volume showed hyperintense LDamide in non-enhancing glioma.

Conclusion
This works illustrates the need for whole tumour coverage to investigate heterogeneity in increased APT-weighted CEST signal in non-enhancing glioma. Future work should investigate whether targeting hyperintense LDamide regions for biopsies improves diagnosis of non-enhancing glioma.
New rules or old concepts? The golden jackal (Canis aureus) and its legal status in Central Europe
Authors: Hatlauf Jennifer , Bayer Kathrin , Trouwborst Arie , Hackländer Klaus 
Published: February 2021

AbstractConflicts have emerged due to range expansions of the golden jackal (Canis aureus) across Europe, characterized by their international conservation status and perceived impacts on livestock and native prey species. Most countries in Central Europe do not yet include the golden jackal in their national list of occurring, native species. Nevertheless, legal obligations arise as soon as golden jackals colonize a particular country. Legal implications of this range expansion were described in past studies from an international perspective. However, they left out specifics on the legal status within any particular country. Therefore, we examine the actual legal status within Central European countries, exemplifying the diverse federal and provincial laws. In particular, we assess the current conservation and hunting laws in Austria’s provinces and discuss them in the context of neighbouring countries to analyse implications for relevant authorities. We found substantial contrasts not only among provinces but also between direct neighbouring countries, impeding efforts for transboundary species conservation and leading to complications regarding the management of this species. Improved procedures for collecting records and hunting-bag data appear necessary for future species assessment on a European level and management on a local level. We recommend a more unified legal system but adjusted to actual golden jackal presence on the regional and cross-border level, combined assessment, or similar management strategies to minimize conflicts, reduce persecution, and clarify legal obligations.
Evaluation of subcarinal lymph node dissection and metastasis in transmediastinal radical esophagectomy
Authors: Shibamoto Jun , Fujiwara Hitoshi , Konishi Hirotaka , Shiozaki Atsushi , Ohashi Takuma , Kubota Takeshi , Shimizu Hiroki , Arita Tomohiro , Yamamoto Yusuke , Morimura Ryo , Kuriu Yoshiaki , Ikoma Hisashi , Okamoto Kazuma , Otsuji Eigo 
Published: February 2021

Abstract
Background
The aim of the present study was to evaluate subcarinal lymph node dissection in transmediastinal radical esophagectomy and subcarinal lymph node metastasis in patients with esophageal cancer.

Methods
Three hundred and twenty-three patients with primary esophageal cancer who underwent transmediastinal or transthoracic esophagectomy with radical two- or three-field lymph node dissection were retrospectively investigated. The clinicopathological characteristics of patients with subcarinal lymph node metastasis were analyzed in detail.

Results
The median of dissected subcarinal lymph nodes in transmediastinal and transthoracic esophagectomy groups was 6 and 7, respectively, and there was no significant difference between the two groups (p = 0.12). Of all patients, 26 (8.0%) were pathologically diagnosed as positive for subcarinal lymph node metastasis, whereas only 7 (26.9%) of those with metastasis were preoperatively diagnosed as positive. In addition, all patients with subcarinal lymph node metastasis had other non-subcarinal lymph node metastasis. By univariate analysis, subcarinal lymph node metastasis was found in larger (≥ 30 mm) and deeper (T3/T4a) primary lesions (p = 0.02 and 0.02, respectively), but it was not found in 49 patients with the primary lesion located in the upper thoracic esophagus.

Conclusions
Subcarinal lymph nodes can be dissected in transmediastinal esophagectomy, almost equivalent to transthoracic esophagectomy. The tumor size, depth, and location may be predictive factors for subcarinal lymph node metastasis.
Free Eu(III) Determination by Donnan Membrane Technique with Electrochemical Detection: Implementation and Evaluation
Authors: Janot Noémie , Groenenberg Jan E. , Otero-Fariña Alba , Pinheiro José Paulo 
Published: February 2021

AbstractThe aim of this study was to develop an analytical method to determine free concentrations of Europium (Eu(III)) in natural waters. Europium(III) in solution was detected using cathodic stripping voltammetry after complexation with N-nitroso-N-phenylhydroxylamine (cupferron). Optimization of analytical parameters allowed us to detect nanomolar levels of Eu(III) in solution. Free Eu(III) in solution was measured using the Donnan membrane technique in which a natural solution (the “donor”, containing various ligands) is separated from a ligand-free solution (the “acceptor”) by a cation-exchange membrane. This membrane allows only non-colloidal cationic species to pass through it, and after an adequate time equilibrium is reached between both compartments. Total Eu(III) concentration can then be quantified in the acceptor solution and related to free Eu(III) in the natural sample. Due to its high valency, free Eu(III) tends to adsorb strongly to the cation-exchange membrane. In order to determine the physicochemical conditions minimizing this adsorption, we analyzed solutions of different Eu(III) and Ca(II) (as background ion) concentrations. Results showed that 100 mM of Ca(II) were necessary to make adsorption of Eu(III) onto the membrane negligible. The optimized setup was then used to quantify Eu(III) complexation in a Eu(III)-dissolved organic matter solution.
Associations Between Anxiety Symptoms and Health-Related Quality of Life: A Population-Based Twin Study in Sri Lanka
Authors: Nas Zeynep , Zavos Helena M. S. , Sumathipala Athula , Jayaweera Kaushalya , Siribaddana Sisira , Hotopf Matthew , Rijsdijk Frühling V. 
Published: February 2021

AbstractAnxiety not only concerns mental wellbeing but also negatively impacts other areas of health. Yet, there is limited research on (a) the genetic and environmental aetiology of such relationships; (b) sex differences in aetiology and (c) non-European samples. In this study, we investigated the genetic and environmental variation and covariation of anxiety symptoms and eight components of health-related quality of life (QoL), as measured by the short form health survey (SF-36), using genetic twin model fitting analysis. Data was drawn from the Colombo Twin and Singleton Study (COTASS), a population-based sample in Sri Lanka with data on twins (N = 2921) and singletons (N = 1027). Individual differences in anxiety and QoL traits showed more shared environmental (family) effects in women. Men did not show familial effects. Anxiety negatively correlated with all eight components of QoL, mostly driven by overlapping unique (individual-specific) environmental effects in both sexes and overlapping shared environmental effects in women. This is the first study in a South Asian population supporting the association between poor mental health and reduced QoL, highlighting the value of integrated healthcare services. Associations were largely environmental, on both individual and family levels, which could be informative for therapy and intervention.
Towards ending the animal cognition war: a three-dimensional model of causal cognition
Authors: Starzak Tobias Benjamin , Gray Russell David 
Published: February 2021

AbstractDebates in animal cognition are frequently polarized between the romantic view that some species have human-like causal understanding and the killjoy view that human causal reasoning is unique. These apparently endless debates are often characterized by conceptual confusions and accusations of straw-men positions. What is needed is an account of causal understanding that enables researchers to investigate both similarities and differences in cognitive abilities in an incremental evolutionary framework. Here we outline the ways in which a three-dimensional model of causal understanding fulfills these criteria. We describe how this approach clarifies what is at stake, illuminates recent experiments on both physical and social cognition, and plots a path for productive future research that avoids the romantic/killjoy dichotomy.
Transcriptomic and genomic variants between koala populations reveals underlying genetic components to disorders in a bottlenecked population
Authors: Tarlinton R. E. , Fabijan J. , Hemmatzadeh F. , Meers J. , Owen H. , Sarker N. , Seddon J. M. , Simmons G. , Speight N. , Trott D. J. , Woolford L. , Emes R. D. 
Published: February 2021

AbstractHistorical hunting pressures on koalas in the southern part of their range in Australia have led to a marked genetic bottleneck when compared with their northern counterparts. There are a range of suspected genetic disorders such as testicular abnormalities, oxalate nephrosis and microcephaly reported at higher prevalence in these genetically restricted southern animals. This paper reports analysis of differential expression of genes from RNAseq of lymph nodes, SNPs present in genes and the fixation index (population differentiation due to genetic structure) of these SNPs from two populations, one in south east Queensland, representative of the northern genotype and one in the Mount Lofty Ranges South Australia, representative of the southern genotype. SNPs that differ between these two populations were significantly enriched in genes associated with brain diseases. Genes which were differentially expressed between the two populations included many associated with brain development or disease, and in addition a number associated with testicular development, including the androgen receptor. Finally, one of the 8 genes both differentially expressed and with a statistical difference in SNP frequency between populations was SLC26A6 (solute carrier family 26 member 6), an anion transporter that was upregulated in SA koalas and is associated with oxalate transport and calcium oxalate uroliths in humans. Together the differences in SNPs and gene expression described in this paper suggest an underlying genetic basis for several disorders commonly seen in southern Australian koalas, supporting the need for further research into the genetic basis of these conditions, and highlighting that genetic selection in managed populations may need to be considered in the future.
Running an XR lab in the context of COVID-19 pandemic: Lessons learned from a Norwegian university
Authors: Garcia Estrada Jose , Prasolova-Førland Ekaterina 
Published: February 2021

AbstractUniversities and companies were not prepared to the changes introduced to limit the spread of COVID-19 in Norway. Universities had to switch to online teaching overnight. There is still uncertainty how measures to control the pandemic will keep affecting universities in the short and middle term. Such measures have consequences on how to carry out research that usually relies on students, researcher and volunteers using the equipment and applications. Our group carries out research on virtual/augmented/extended reality (VR/AR/XR) for immersive training and learning. This research often involves user studies. We had established procedures on how to use the equipment, carry out demonstrations and teaching for students, teachers and visitors, develop projects as part of bachelor and master projects and test new applications with volunteers. The measures taken by authorities to control the spread of the pandemic made it difficult or unfeasible to carry out some of those activities. In this paper we describe how our group and XR lab reacted after universities were closed to students’ presence in campus in March 2020. We present our actions to keep research ongoing, our evaluation of some of those actions and discuss how we had to change the way we operate our XR lab in order to continue teaching and research in the near future, under the assumption that restrictions due to the pandemic can be re-implemented at short notice. We propose procedures to run an XR lab in a manner that inspires visitors to feel safe and confident of using the equipment. Our contribution is the proposal of procedures to run an educational XR lab safely and contribute towards the conversation about how to carry out research involving users in XR under pandemic restrictions.
Identification of ‘Candidatus Phytoplasma’ species in “huanglongbing” infected citrus orchards in the Caribbean
Authors: Luis-Pantoja Maritza , Paredes-Tomás Camilo , Uneau Youri , Myrie Wayne , Morillon Raphael , Satta Eleonora , Contaldo Nicoletta , Pacini Francesco , Bertaccini Assunta 
Published: February 2021

Abstract“Huanglongbing” (HLB) is one of the most devastating diseases of citrus orchards worldwide. Samples from 183 citrus plants of different cultivars and rootstock/cultivar combinations, showing HLB symptoms in three Caribbean countries (Cuba, Jamaica, and Guadeloupe-France), were collected to verify the possible co-infection of ‘Candidatus Phytoplasma’ and ‘Candidatus Liberibacter’ species. The 64% of the samples resulted positive to the ‘Ca. L. asiaticus’ and the 27% to diverse ‘Ca. Phytoplasma’-related species, moreover about the 14% of the samples infected with ‘Ca. Liberibacter’ were also found positive to phytoplasmas, indicating the presence of mixed infection especially in the orchards located in Cuba. Moreover, in one of the samples from Jamaica mixed phytoplasma infection was detected. Moreover the detection of only phytoplasmas in 11 symptomatic citrus samples collected from Cuba and Guadeloupe without ‘Ca. Liberibacter’ detection, confirmed that the symptomatology cannot be the sole criterium to discriminate between the presence of the two pathogens, and molecular detection is necessary to identify single or mixed infections. Diaphorina citri insects collected from Cuba and Guadeloupe resulted infected with ‘Ca. L. asiaticus’ confirming its active role in the dissemination of the pathogen. Only one insect of the Cicadidae family, collected in Guadeloupe, was found positive for phytoplasma presence. Considering that the phytoplasmas belonging to some ‘Candidatus species’ were detected in the three countries in different citrus varieties, a relevant role as phytoplasma reservoir can be attribute to citrus orchards.
Introducing urine-enriched biochar-based fertilizer for vegetable production: acceptability and results from rural Bangladesh
Authors: Sutradhar Ipsita , Jackson-deGraffenried Meredith , Akter Sayema , McMahon Shannon A. , Waid Jillian L. , Schmidt Hans-Peter , Wendt Amanda S. , Gabrysch Sabine 
Published: February 2021

AbstractImproved agricultural practices that increase yields and preserve soils are critical to addressing food insecurity and undernutrition among smallholder farmer families. Urine-enriched biochar has been shown to be an accessible and effective fertilization option in various subtropical countries; however, it is new to Bangladesh. To better understand attitudes and experiences preparing and using urine-enriched biochar fertilizer, mixed-methods research was undertaken among smallholder farmers in northeastern Bangladesh in 2016/2017. In-depth interviews were conducted with 25 respondents who had compared the production of crops grown with biochar-based fertilizer to usual practice. In addition, in areas where trainings on biochar-based fertilization had been offered, 845 farmers were asked about their experience through a quantitative survey. Interview results indicated that cow urine-enriched biochar was favored over human urine because cow urine was perceived as clean and socially acceptable, whereas human urine was considered impure and disgusting. Respondents praised biochar-based fertilizer because it increased yields, cost little, was convenient to prepare with readily available natural materials, produced tastier crops, and allowed families to share their larger yields which in turn enhanced social and financial capital. Comparative field trials indicated a 60% yield benefit in both cabbage and kohlrabi crops. Challenges included uneven access to ingredients, with some respondents having difficulty procuring cow urine and biomass feedstock. The low social, health, and financial risk of adoption and the perceived benefits motivated farmers to produce and apply biochar-based fertilizer in their gardens, demonstrating strong potential for scale-up of this technology in Bangladesh.
Eco-efficiency and effectiveness evaluation toward sustainable urban development in China: a super-efficiency SBM–DEA with undesirable outputs
Authors: Long Liang-jun 
Published: February 2021

AbstractEco-efficiency, especially the total-factor eco-efficiency, measured by DEA models considering undesirable outputs, has been a popular instrument to evaluate sustainable development in recent years. However, sustainable development pursues not only high eco-efficiency which ensures that the utilization of natural resource and environment is in a sustainable way, but also good effectiveness which ensures that the development is in the right direction. In this paper, firstly, the efficiency of sustainable urban development is measured, i.e., measuring the eco-efficiency of 35 major cities in China during the period of 2011–2015 based on a super-efficiency SBM–DEA model with undesirable outputs and the Malmquist–Luenberger index is used to explore the dynamic change of eco-efficiency. Secondly, the effectiveness of urban development is measured by overall well-being including urban HDI and life satisfaction. Thirdly, a comprehensive analysis based on efficiency and effectiveness is conducted to evaluate sustainable urban development. The results indicate that: (1) the overall efficiency of 35 major cities in China as a whole is at a low level during the 12th five-year plan period, and the improvement of total-factor ecological productivity is mainly enhanced by technological progress. (2) With regarding to the effectiveness of urban development, Hangzhou, Jinan, Ningbo, Xiamen and Qingdao rank top five, while the cities with a high level of urban HDI like Guangzhou, Changsha and Beijing only rank in the middle due to a relatively low level of life satisfaction. (3) Based on efficiency and effectiveness, most of the cities perform with a low-level efficiency or poor effectiveness, only four cities including Qingdao, Changchun, Ningbo and Tianjin perform with a relatively high efficiency and good effectiveness. Finally, some implications and policy suggestions are proposed based on the above findings.
Knowledge as Justified True Belief
Authors: de Grefte Job 
Published: February 2021

AbstractWhat is knowledge? I this paper I defend the claim that knowledge is justified true belief by arguing that, contrary to common belief, Gettier cases do not refute it. My defence will be of the anti-luck kind: I will argue that (1) Gettier cases necessarily involve veritic luck, and (2) that a plausible version of reliabilism excludes veritic luck. There is thus a prominent and plausible account of justification according to which Gettier cases do not feature justified beliefs, and therefore, do not present counterexamples to the tripartite analysis. I defend the account of justification against objections, and contrast my defence of the tripartite analysis to similar ones from the literature. I close by considering some implications of this way of thinking about justification and knowledge.
A Contextual Planck Parameter and the Classical Limit in Quantum Cosmology
Authors: Barrow John D. , Magueijo João 
Published: February 2021

AbstractWe propose that whatever quantity controls the Heisenberg uncertainty relations (for a given complementary pair of observables) it should be identified with an effective Planck parameter. With this definition it is not difficult to find examples where the Planck parameter depends on the region under study, varies in time, and even depends on which pair of observables one focuses on. In quantum cosmology the effective Planck parameter depends on the size of the comoving region under study, and so depends on that chosen region and on time. With this criterion, the classical limit is expected, not for regions larger than the Planck length, $$l_{P}$$

l
P

, but for those larger than $$l_{Q}=(l_{P}^{2}H^{-1})^{1/3}$$

l
Q

=

(

l

P

2

H

-
1

)

1
/
3

, where H is the Hubble parameter. In theories where the cosmological constant is dynamical, it is possible for the latter to remain quantum even in contexts where everything else is deemed classical. These results are derived from standard quantization methods, but we also include more speculative cases where ad hoc Planck parameters scale differently with the length scale under observation. Even more speculatively, we examine the possibility that similar complementary concepts affect thermodynamical variables, such as the temperature and the entropy of a black hole.