bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bridge to bigpush or backwash? Market integration, reallocation and productivity effects of Jamuna Bridge in Bangladesh
Authors: Blankespoor Brian , Emran M Shahe , Shilpi Forhad , Xu Lu 
Published: June 2021

Abstract
We study the effects of Jamuna Bridge in Bangladesh that reduced the average trade costs by 50% and connected 26 million people by road to the capital city. We use a difference-in-difference design where the isolated Padma hinterland constitutes the comparison. Balance tests for an array of economic characteristics support the parallel trends assumption. The bridge led to economic revival in the Jamuna hinterland with increased agricultural productivity and population density despite a decline in the share of manufacturing employment. The effects are spatially heterogeneous with substantial manufacturing decline in the middle subregion, and the remote areas reaping the highest benefits.
Population dynamics of the heather vole (Phenacomys intermedius) in commercial forest landscapes of south-central British Columbia, Canada
Authors: Sullivan Thomas P , Sullivan Druscilla S 
Published: June 2021

AbstractLong-term population dynamics are essentially unknown for the western heather vole (Phenacomys intermedius), a relatively rare microtine species. Our objectives were to provide a description of demographic changes in populations of P. intermedius and determine possible causes of these changes. We analyzed four detailed 12- to 22-year data sets that recorded changes in abundance of P. intermedius in a variety of managed forests in south-central British Columbia, Canada from 1993 to 2018. We evaluated three hypotheses (H) that may help explain population changes: heather voles will (H1) have higher populations in sites with (i) abundant dwarf shrubs or (ii) cover of woody debris; (H2) colonize new clear-cuts as dispersal sinks for young voles; and (H3) be at lower abundance when other Microtus species are present at equal or higher numbers. Populations of P. intermedius occurred commonly at ≤ 1 animal/ha (as a density index). However, in favorable habitats such as some new clear-cuts and in “open” pine stands, P. intermedius occurred at mean annual peak numbers of 5–6/ha (as a density index). There were two relatively high populations of P. intermedius in 1994–1995 and 1998, and possibly again in 2002 in the open pine stands. Mean numbers of lactating females and recruits per year tended to follow the pattern of changes in abundance. High populations of P. intermedius occurred in stands with abundant dwarf shrubs in open pine stands but not those with a cover of woody debris structures in clear-cuts, H1, therefore, was only partially supported. A relatively higher proportion of adult than juvenile heather voles on clear-cuts did not support H2: that these harvested sites would be dispersal sinks for young voles. Mean annual numbers of P. intermedius were positively correlated with those of M. longicaudus, at least on clear-cut sites, hence H3 was not supported. Phenacomys intermedius was essentially absent from our closed-canopy mature/old-growth forests but occurred in many managed forest habitats at low abundance (density index of ≤ 1/ha). In early successional habitats after clear-cutting and in open young pine stands this species occurred at moderate abundance and generally appeared stable in numbers across these forest landscapes.
PtBRI1.2 promotes shoot growth and wood formation through a brassinosteroid-mediated PtBZR1-PtWNDs module in poplar
Authors: Jiang Chunmei , Li Bei , Song Zhizhong , Zhang Yuliang , Yu Chunyan , Wang Haihai , Wang Limin , Zhang Hongxia 
Published: June 2021

Abstract
Brassinosteroid-insensitive-1 (BRI1) plays important roles in various signalling pathways controlling plant growth and development. However, the regulatory mechanism of BRI1 in brassinosteroid (BR)-mediated signalling for shoot growth and wood formation in woody plants is largely unknown. In this study, PtBRI1.2, a brassinosteroid-insensitive-1 gene, was overexpressed in poplar. Shoot growth and wood formation of transgenic plants were examined and the regulatory genes involved were verified. PtBRI1.2 was localized to the plasma membrane, with a predominant expression in leaves. Ectopic expression of PtBRI1.2 in Arabidopsis bri1-201 and bri1-5 mutants rescued their retarded-growth phenotype. Overexpression of PtBRI1.2 in poplar promoted shoot growth and wood formation in transgenic plants. Further studies revealed that overexpression of PtBRI1.2 promoted the accumulation of PtBZR1 (BRASSINAZOLE RESISTANT1) in the nucleus, which subsequently activated PtWNDs (WOOD-ASSOCIATED NAC DOMAIN transcription factors) to up-regulate expression of secondary cell wall biosynthesis genes involved in wood formation. Our results suggest that PtBRI1.2 plays a crucial role in regulating shoot growth and wood formation by activating BR signalling.
3D gas-phase elemental abundances across the formation histories of Milky Way-mass galaxies in the FIRE simulations: initial conditions for chemical tagging
Authors: Bellardini Matthew A , Wetzel Andrew , Loebman Sarah R , Faucher-Giguère Claude-André , Ma Xiangcheng , Feldmann Robert 
Published: June 2021

ABSTRACT
We use FIRE-2 simulations to examine 3D variations of gas-phase elemental abundances of [O/H], [Fe/H], and [N/H] in 11 MW and M31-mass galaxies across their formation histories at z ≤ 1.5 ($t_{\rm lookback} \le 9.4 \, \rm {Gyr}$), motivated by characterizing the initial conditions of stars for chemical tagging. Gas within $1 \, \rm {kpc}$ of the disc mid-plane is vertically homogeneous to $\lesssim 0.008 \, \rm {dex}$ at all z ≤ 1.5. We find negative radial gradients (metallicity decreases with galactocentric radius) at all times, which steepen over time from $\approx \! -0.01 \, \rm {dex}\, \rm {kpc}^{-1}$ at z = 1 ($t_{\rm lookback} = 7.8 \, \rm {Gyr}$) to $\approx \! -0.03 \, \rm {dex}\, \rm {kpc}^{-1}$ at z = 0, and which broadly agree with observations of the MW, M31, and nearby MW/M31-mass galaxies. Azimuthal variations at fixed radius are typically $0.14 \, \rm {dex}$ at z = 1, reducing to $0.05 \, \rm {dex}$ at z = 0. Thus, over time radial gradients become steeper while azimuthal variations become weaker (more homogeneous). As a result, azimuthal variations were larger than radial variations at z ≳ 0.8 ($t_{\rm lookback} \gtrsim 6.9 \, \rm {Gyr}$). Furthermore, elemental abundances are measurably homogeneous (to ≲0.05 dex) across a radial range of $\Delta R \approx 3.5 \, \rm {kpc}$ at z ≳ 1 and $\Delta R \approx 1.7 \, \rm {kpc}$ at z = 0. We also measure full distributions of elemental abundances, finding typically negatively skewed normal distributions at z ≳ 1 that evolve to typically Gaussian distributions by z = 0. Our results on gas abundances inform the initial conditions for stars, including the spatial and temporal scales for applying chemical tagging to understand stellar birth in the MW.
Arbitrating the S8 discrepancy with growth rate measurements from redshift-space distortions
Authors: Nunes Rafael C , Vagnozzi Sunny 
Published: June 2021

ABSTRACT
Within the Lambda cold dark matter (ΛCDM) model, measurements from recent cosmic microwave background (CMB) and weak lensing (WL) surveys have uncovered a ∼3σ disagreement in the inferred value of the parameter $S_8 \equiv \sigma _8\sqrt{\Omega _\mathrm{ m}/0.3}$, quantifying the amplitude of late-time matter fluctuations. Before questioning whether the S8 discrepancy calls for new physics, it is important to assess the view of measurements other than CMB and WL ones on the discrepancy. Here, we examine the role of measurements of the growth rate f(z) in arbitrating the S8 discrepancy, considering measurements of fσ8(z) from redshift-space distortions (RSDs). Our baseline analysis combines RSD measurements with geometrical measurements from baryon acoustic oscillations (BAO) and Type Ia Supernovae (SNeIa), given the key role of the latter in constraining Ωm. From this combination and within the ΛCDM model, we find $S_8 = 0.762^{+0.030}_{-0.025}$, and quantify the agreement between RSD + BAO + SNeIa and Planck to be at the 2.2σ level: the mild disagreement is therefore compatible with a statistical fluctuation. We discuss combinations of RSD measurements with other data sets, including the EG statistic. This combination increases the discrepancy with Planck, but we deem it significantly less robust. Our earlier results are stable against an extension where we allow the dark energy equation of state w to vary. We conclude that, from the point of view of combined growth rate and geometrical measurements, there are hints, but no strong evidence yet, for the Planck ΛCDM cosmology overpredicting the amplitude of matter fluctuations at redshifts z ≲ 1. From this perspective, it might therefore still be premature to claim the need for new physics from the S8 discrepancy.
In-depth analysis of evolving binary systems that produce nova eruptions
Authors: Hillman Yael 
Published: June 2021

ABSTRACT
This study is the direct continuation of a previous work performed by Hillman et al., where they used their feedback dominated numerical simulations to model the evolution of four initial models with white dwarf (WD) masses of 0.7 and $1.0\, \mathrm{M}_\odot$ and red dwarf (RD) masses of 0.45 and $0.7\, \mathrm{M}_\odot$ from first Roche lobe contact of the donor RD, over a few times 109 yr, until the RD was eroded down to below $0.1\, \mathrm{M}_\odot$. This study presents an in-depth analysis of their four models complimented by three models with a higher WD mass of $1.25\, \mathrm{M}_\odot$, one of which comprises an oxygen-neon (ONe) core. Common features were found for all seven models on a secular time-scale as well as on a cyclic time-scale. On the other hand, certain features were found that are strongly dependent either on the WD or the RD mass but are indifferent to the other of the two. Additionally, a model with a WD composed of an ONe core was compared with its corresponding carbon oxygen (CO) core WD model and found to have a significant impact on the heavy element abundances in the ejecta composition.
Andromeda XXI – a dwarf galaxy in a low-density dark matter halo
Authors: Collins Michelle L M , Read Justin I , Ibata Rodrigo A , Rich R Michael , Martin Nicolas F , Peñarrubia Jorge , Chapman Scott C , Tollerud Erik J , Weisz Daniel R 
Published: June 2021

ABSTRACT
Andromeda XXI (And XXI) has been proposed as a dwarf spheroidal galaxy with a central dark matter density that is lower than expected in the standard $\Lambda$ cold dark matter ($\Lambda$CDM) cosmology. In this work, we present dynamical observations for 77 member stars in this system, more than doubling previous studies to determine whether this galaxy is truly a low-density outlier. We measure a systemic velocity of $v_r=-363.4\pm 1.0{\rm \, km\, s^{-1}}$ and a velocity dispersion of $\sigma _v=6.1^{+1.0}_{-0.9}{\rm \, km\, s^{-1}}$, consistent with previous work and within $1\sigma$ of predictions made using the modified Newtonian dynamics framework. We also measure the metallicity of our member stars from their spectra, finding a mean value of ${\rm [Fe/H]}=-1.7\pm 0.1$ dex. We model the dark matter density profile of And XXI using an improved version of gravsphere, finding a central density of $\rho _{\rm DM}({\rm 150 pc})=2.6_{-1.5}^{+2.4} \times 10^7 \, {\rm M_\odot \, kpc^{-3}}$ at 68 per cent confidence, and a density at two half-light radii of $\rho _{\rm DM}({\rm 1.75 kpc})=0.9_{-0.2}^{+0.3} \times 10^6 \, {\rm M_\odot \, kpc^{-3}}$ at 68 per cent confidence. These are both a factor of${\sim }3\!-\!5$ lower than the densities expected from abundance matching in $\Lambda$CDM. We show that this cannot be explained by ‘dark matter heating’ since And XXI had too little star formation to significantly lower its inner dark matter density, while dark matter heating only acts on the profile inside the half-light radius. However, And XXI’s low density can be accommodated within $\Lambda$CDM if it experienced extreme tidal stripping (losing ${\gt}95{{\ \rm per\ cent}}$ of its mass), or if it inhabits a low-concentration halo on a plunging orbit that experienced repeated tidal shocks.
Origin of stellar prolate rotation in a cosmologically simulated faint dwarf galaxy
Authors: Cardona-Barrero Salvador , Battaglia Giuseppina , Di Cintio Arianna , Revaz Yves , Jablonka Pascale 
Published: June 2021

ABSTRACT
Stellar prolate rotation in dwarf galaxies is rather uncommon, with only two known galaxies in the Local Group showing such feature (Phoenix and And II). Cosmological simulations show that in massive early-type galaxies prolate rotation likely arises from major mergers. However, the origin of such kinematics in the dwarf galaxies regime has only been explored using idealized simulations. Here, we made use of hydrodynamical cosmological simulations of dwarfs galaxies with stellar mass between 3 × 105 and 5 × 108  M⊙ to explore the formation of prolate rotators. Out of 27 dwarfs, only one system showed clear rotation around the major axis, whose culprit is a major merger at $z$ = 1.64, which caused the transition from an oblate to a prolate configuration. Interestingly, this galaxy displays a steep metallicity gradient, reminiscent of the one measured in Phoenix and And II: this is the outcome of the merger event that dynamically heats old, metal-poor stars, and of the centrally concentrated residual star formation. Major mergers in dwarf galaxies offer a viable explanation for the formation of such peculiar systems, characterized by steep metallicity gradients and prolate rotation.
Formation of frameshift-stimulating RNA pseudoknots is facilitated by remodeling of their folding intermediates
Authors: Hsu Chiung-Fang , Chang Kai-Chun , Chen Yi-Lan , Hsieh Po-Szu , Lee An-I , Tu Jui-Yun , Chen Yu-Ting , Wen Jin-Der 
Published: June 2021

Abstract
Programmed –1 ribosomal frameshifting is an essential regulation mechanism of translation in viruses and bacteria. It is stimulated by mRNA structures inside the coding region. As the structure is unfolded repeatedly by consecutive translating ribosomes, whether it can refold properly each time is important in performing its function. By using single-molecule approaches and molecular dynamics simulations, we found that a frameshift-stimulating RNA pseudoknot folds sequentially through its upstream stem S1 and downstream stem S2. In this pathway, S2 folds from the downstream side and tends to be trapped in intermediates. By masking the last few nucleotides to mimic their gradual emergence from translating ribosomes, S2 can be directed to fold from the upstream region. The results show that the intermediates are greatly suppressed, suggesting that mRNA refolding may be modulated by ribosomes. Moreover, masking the first few nucleotides of S1 favors the folding from S2 and yields native pseudoknots, which are stable enough to retrieve the masked nucleotides. We hypothesize that translating ribosomes can remodel an intermediate mRNA structure into a stable conformation, which may in turn stimulate backward slippage of the ribosome. This supports an interactive model of ribosomal frameshifting and gives an insightful account addressing previous experimental observations.
Worsening Disparities in State-Level Uptake of Human Immunodeficiency Virus Preexposure Prophylaxis, 2014–2018
Authors: Powers Samuel D , Rogawski McQuade Elizabeth T , Killelea Amy , Horn Tim , McManus Kathleen A 
Published: June 2021

Abstract
Retrospective analysis of human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) use among individuals with PrEP indications demonstrates worsening disparities in uptake between early- and late-adopting states from 2014 to 2018. To end the HIV epidemic, federal and state governments must close gaps by translating successful policies from early-adopting states to late-adopting states.
Effectiveness of Bezlotoxumab for Prevention of Recurrent Clostridioides difficile Infection Among Transplant Recipients
Authors: Johnson Tanner M , Howard Amanda H , Miller Matthew A , Allen Lorna L , Huang Misha , Molina Kyle C , Bajrovic Valida 
Published: June 2021

Abstract

Background
Bezlotoxumab significantly reduces the incidence of recurrent Clostridioides difficile infection (CDI); however, limited data are available in solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients.

Methods
We conducted a single-center retrospective analysis comparing recurrent CDI in SOT and HCT recipients receiving standard of care alone (oral vancomycin, fidaxomicin, or metronidazole) or bezlotoxumab plus standard of care. The primary outcome was 90-day incidence of recurrent CDI, and secondary outcomes included 90-day hospital readmission, mortality, and incidence of heart failure exacerbation.

Results
Overall, 94 patients received bezlotoxumab plus standard of care (n = 38) or standard of care alone (n = 56). The mean age was 53 years; patients had a median of 3 prior Clostridioides difficile episodes and 4 risk factors for recurrent infection. Most patients were SOT recipients (76%), with median time to index CDI occurring 2.7 years after transplantation. Ninety-day recurrent CDI occurred in 16% (6/38) in the bezlotoxumab cohort compared to 29% (16/56) in the standard of care cohort (P = .13). Multivariable regression revealed that bezlotoxumab was associated with significantly lower odds of 90-day recurrent CDI (odds ratio, 0.28 [95% confidence interval, .08–.91]). There were no differences in secondary outcomes, and no heart failure exacerbations were observed.

Conclusions
In a cohort of primarily SOT recipients, bezlotoxumab was well tolerated and associated with lower odds of recurrent CDI at 90 days. Larger, prospective trials are needed to confirm these findings among SOT and HCT populations.
Impact of Previous Coronavirus Disease 2019 on Immune Response After a Single Dose of BNT162b2 Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine
Authors: Velasco María , Galán Maria Isabel , Casas Maria Luisa , Pérez-Fernández Elia , Martínez-Ponce Diana , González-Piñeiro Beatriz , Castilla Virgilio , Guijarro Carlos ,   Alcorcón COVID-19 Working Group, Algora Weber Alejandro , Alonso Punter Juan Carlos , Bonilla Zafra Gregorio , Bueno Campaña Mª Mercedes , Carrión Pulido Camilo , Diaz Cuasante Ana Isabel , Fabero Jiménez Aurora , Fariña García Rosa María , González Anglada María Isabel , Izquierdo Patrón Mª Mercedes , Lorenzo Martínez Susana , Mosquera González Margarita , Pérez Encinas Montserrat , Pérez Fernandez Elia , Pérez Vega Francisco José , Sánchez Renilla , Esther Maria , Goyanes Galán Mª José , Losa-García Juan Emilio , Rodriguez-Caravaca Gil 
Published: June 2021

Abstract
Immune response after a single dose of BNT162b2 vaccine was markedly increased in subjects with previous severe acute respiratory syndrome coronavirus 2 infection, reaching similar immunoglobulin titers to those elicited by the full 2 doses in naive cases, and increased modestly after the second dose. These data may inform the priority of the boosting dose.
Elevated Levels of the Endothelial Molecules ICAM-1, VEGF-A, and VEGFR2 in Microscopic Asymptomatic Malaria
Authors: Frimpong Augustina , Amponsah Jones , Agyemang Dorothy , Adjokatseh Abigail Sena , Eyiah-Ampah Sophia , Ennuson Nana Aba , Obiri Dorotheah , Amoah Linda Eva , Kusi Kwadwo Asamoah 
Published: June 2021

Abstract

Background
In malaria, clinical disease has been associated with increased levels of endothelial activation due to the sequestration of infected erythrocytes. However, the levels and impact of endothelial activation and pro-angiogenic molecules such as vascular endothelial growth factor (VEGF)–A and its receptor vascular endothelial growth factor receptor 2 (VEGFR2) in asymptomatic malaria have not been well characterized.

Methods
Blood samples were obtained from community children for malaria diagnosis using microscopy and polymerase chain reaction. A multiplex immunoassay was used to determine the levels of intracellular adhesion molecule (ICAM)–1, vascular endothelial growth factor (VEGF)–A, and VEGFR2 in the plasma of children with microscopic or submicroscopic asymptomatic parasitemia and compared with levels in uninfected controls.

Results
Levels of ICAM-1, VEGF-A, and VEGFR2 were significantly increased in children with microscopic asymptomatic parasitemia compared with uninfected controls. Also, levels of VEGF-A were found to be inversely associated with age. Additionally, a receiver operating characteristic analysis revealed that plasma levels of ICAM-1 (area under the curve [AUC], 0.72) showed a moderate potential in discriminating between children with microscopic malaria from uninfected controls when compared with VEGF-A (AUC, 0.67) and VEGFR2 (AUC, 0.69).

Conclusions
These data imply that endothelial activation and pro-angiogenic growth factors could be one of the early host responders during microscopic asymptomatic malaria and may play a significant role in disease pathogenesis.
What Are the Most Important Problems in Functioning Among Patients With Shoulder Pain? An Analysis of the Patient-Specific Functional Scale
Authors: Røe Yngve , Rysstad Tarjei , Tveter Anne Therese , Sandbakk Torill Bjugan , Jæger Marit , Grotle Margreth 
Published: June 2021

Abstract

Objective
The purpose of this study was to identify important functional problems among individuals with shoulder pain using the Patient-Specific Functional Scale (PSFS) and to investigate differences between individuals receiving primary care and individuals receiving secondary care.

Methods
In this cross-sectional study located in a primary and secondary care outpatient clinic, a total of 177 individuals seeking care for shoulder pain (84 from primary care and 93 from secondary care) were recruited. Background variables, pain, physical activity, and PSFS responses were collected using a questionnaire software package. Meaningful concepts were linked from the PSFS responses to the International Classification of Functioning, Disability and Health (ICF) according to established rules. Frequencies for the ICF categories were estimated separately for primary care and secondary care. Differences between primary care and secondary care were investigated by calculating CIs for the sample proportions at ICF chapter level.

Results
The primary care sample reported functional problems linked to 226 ICF categories, whereas the secondary care sample reported functional problems linked to 337 ICF categories. Of the linked ICF categories, 87.7% belonged to the Activities and Participation component of the ICF. Seventeen categories were identified in &gt;3% of the individuals; of those, the most frequent categories were recreation and leisure, lifting and carrying objects, doing housework, hand and arm use, and remunerative employment. Categories included in the ICF chapters of self-care and domestic life were significantly more frequent in the secondary care sample, whereas there was a trend that neuromusculoskeletal and movement-related functions were more frequent in primary care.

Conclusion
The present findings indicate that individuals with shoulder pain report a wide range of functional problems, from basic functions related to mobility to activities related to work and leisure. This study also discovered differences between patients in primary care and secondary care. The large variation in the experiences between people supports the use of an individualized measure in assessments.

Impact
This study adds new knowledge about problems in functioning among people with shoulder pain and how the individual experience varies between primary care and secondary care settings. Moreover, the content analyses used in this study showed the full potential of the ICF classification and should have potential for further application.