bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Management of Intussusception in Children: A Retrospective Review of 212 Cases
Authors: Ghritlaharey Rajendra K. 
Published: October 2021

Objectives
The primary objective of this study was to analyze and review the demographics of children operated upon for intussusception. Secondary objectives were to review the clinical characteristics, surgical procedures performed, postoperative complications, and outcome.

Materials and Methods
It is a single-institution, retrospective study and consists of children below the age of 12 years. This study was conducted at the author's department of pediatric surgery for the past 21 years, from January 1, 2000 to December 31, 2020.

Results
During the study period, 212 children were operated upon for intussusceptions and included 146 (68.86%) boys and 66 (31.13%) girls. This review consisted of infants 158 (74.52%), and children of 1 to 5 years of age (30; 14.15%), and 6 to 12 years of age (24; 11.32%). Clinically, 177 (83.49%) children presented with the features of acute intestinal obstruction, and the remaining 35 (16.5%) presented with features of perforation peritonitis. Primary (idiopathic) intussusception was documented in 188 (88.67%) of the cases. Gangrenous bowel was evident in 98 (46.22%) children. Sixty-two percent of the cases required bowel resection. Surgical procedures were executed in children for intussusception in the following order of frequency: (1) operative reduction with or without serosal tear/bowel perforation repair, n = 81 (38.2%); (2) resection of diseased ileum and ileoileal anastomosis, n = 52 (24.52%); (3) resection of diseased ileum ± part of colon and an ileostomy, n = 36 (16.98%); and (4) resection of diseased ileum, cecum, part of colon, and ileocolic (ileo-ascending or ileo-transverse) anastomosis, n = 43 (20.28%). Postoperatively, 9 (4.24%) children required reexploration for the management of their complications. Twenty-one (9.9%) children died during the postoperative period.

Conclusion
Intussusception remains the most common cause of acute intestinal obstruction in infants and young children. Delay in the referral, diagnosis, and seeking treatment were significantly associated with bowel gangrene, required bowel resection during the surgical therapy, and also culminated in significantly higher mortalities.
Fabry–Pérot cavities and quantum dot formation at gate-defined interfaces in twisted double bilayer graphene
Authors: Portolés Elías , Zheng Giulia , de Vries Folkert K , Zhu Jihang , Tomić Petar , Taniguchi Takashi , Watanabe Kenji , MacDonald Allan H , Ensslin Klaus , Ihn Thomas , Rickhaus Peter 
Published: October 2021

Abstract
The rich and electrostatically tunable phase diagram exhibited by moiré materials has made them a suitable platform for hosting single material, multi-purpose devices. To engineer such devices, understanding electronic transport and localization across electrostatically defined interfaces is of fundamental importance. Little is known, however, about how the interplay between the band structure originating from the moiré lattice and electric potential gradients affects electronic confinement. Here, we electrostatically define a cavity across a twisted double bilayer graphene sample. We observe two kinds of Fabry–Pérot (FP) oscillations. The first, independent of charge polarity, stems from confinement of electrons between dispersive-band/flat-band interfaces. The second arises from junctions between regions tuned into different flat bands. When tuning the out-of-plane electric field across the device, we observe Coulomb blockade resonances in transport. This is an indication of strong electronic confinement. From the gate, magnetic field and source-drain voltage dependences of the resonances, we conclude that quantum dots form at the interfaces of the FP cavity. Our results constitute a first step toward better understanding interfacial phenomena in single crystal moiré devices.
Sol-gel-processed amorphous-phase ZrO2 based resistive random access memory
Authors: Kim Kyoungdu , Hong Woongki , Lee Changmin , Lee Won-Yong , Kim Do Won , Kim Hyeon Joong , Kwon Hyuk-Jun , Kang Hongki , Jang Jaewon 
Published: October 2021

Abstract
In this study, sol–gel-processed amorphous-phase ZrO2 was used as an active channel material to improve the resistive switching properties of resistive random access memories (RRAMs). ITO/ZrO2/Ag RRAM devices exhibit the properties of bipolar RRAMs. The effect of the post-annealing temperature on the electrical properties of the ZrO2 RRAM was investigated. Unlike the ZrO2 films annealed at 400 and 500 °C, those annealed at 300 °C were in amorphous phase. The RRAM based on the amorphous-phase ZrO2 exhibited an improved high-resistance state (HRS) to low-resistance state ratio (over 106) as well as promising retention and endurance characteristics without deterioration. Furthermore, its disordered nature, which causes efficient carrier scattering, resulted in low carrier mobility and the lowest leakage current, influencing the HRS values.
Spatial estimation of fundamental mode dispersion curves using geostatistical techniques
Authors: Aguilar-Velázquez Manuel J , Gil-Vargas Nelson Alejandro , Pérez-Campos Xyoli , Baena-Rivera Marcela , Ramirez-Guzman Leonardo 
Published: October 2021

SUMMARY
This paper proposes the use of geostatistical techniques to estimate dispersion curves between other known ones. To do it, we introduce two novel methodologies: the stacking method and the group-velocity mapping method. We obtain our set of group-velocity fundamental mode dispersion curves from seismic noise correlation. Consequently, we first assign their attribution point at the mid-distance between the stations used for the dispersion curves calculation. The stacking method uses the range of the omnidirectional semivariogram of a regionalized variable that quantifies the similarity between dispersion curves to stack them according to their spatial correlation. We test this technique with dispersion curves obtained in Mexico City and get a range of ∼400 m for the omnidirectional semivariogram. We also calculate directional semivariograms and observe a maximum range (∼500 m) in the NW-SE direction, agreeing with the city's spatial distribution of natural periods. On the other hand, the group-velocity mapping method uses the ordinary kriging estimator in the group velocities for all the ranges of periods to generate maps and then dispersion curves. Estimated dispersion curves retrieved from both, the stacking and the group-velocity mapping method, were compared with those obtained with the fast marching tomographic method. We also establish analogies between getting group-velocity maps with the tomographic method and with the group-velocity mapping method. Finally, we observe that the range of the omnidirectional semivariogram used in the stacking method may be related to the tomographic method resolution.
Impacts of geometric model simplifications on wave propagation—application to ground motion simulation in the lower Var valley basin (France)
Authors: Anquez Pierre , Glinsky Nathalie , Cupillard Paul , Caumon Guillaume 
Published: October 2021

SUMMARYThe numerical simulation of seismic wave propagation in realistic heterogeneous media, as sedimentary basins, is a key element of seismic hazard estimation. Many numerical methods in two dimensions are based on unstructured triangular meshes and explicit time schemes. However, the presence of thin layers and tangential stratigraphic contacts in sedimentary basins entails poorly shaped mesh elements: some triangle heights are extremely small compared to the edge lengths, which requires small time steps in the simulations and thus leads to prohibitive computation times. We compare manual and automatic geological model simplification techniques to modify problematic areas of the domain, so as to improve the quality of the triangulated mesh. We modify the shape and the connectivity between rock units in the basin, with the objective to reduce the computation time without significantly changing the physical response of the geological medium. These simplification techniques are applied in an investigation of site effects in the lower Var valley, a densely urbanized area located near the city of Nice (southeast of France). Numerical simulations of plane wave propagation in a heterogeneous 2-D profile are carried out with a discontinuous Galerkin finite element method. Five simplified meshes are generated and the impacts of the simplifications are analysed in comparison to the reference model. We compare the time solutions and the transfer functions obtained on the surface of the basin. The results show that the simplification procedures, in particular automatic modifications of the model, yield a significant performance gain, with a ratio higher than 55, while having a negligible impact on the ground motion response.
An analysis of core–mantle boundary Stoneley mode sensitivity and sources of uncertainty
Authors: Robson Alexander , Lau Harriet C P , Koelemeijer Paula , Romanowicz Barbara 
Published: October 2021

SUMMARYStoneley modes are a special subset of normal modes whose energy is confined along the core–mantle boundary (CMB). As such, they offer a unique glimpse into Earth structure at the base of the mantle. They are often observed through coupling with mantle modes due to rotation, ellipticity and lateral heterogeneity, though they can be detected without such coupling. In this study, we explore the relative sensitivities of seismic spectra of two low-frequency Stoneley modes to several factors, taking as reference the fully coupled computation up to 3 mHz in model S20RTS. The factors considered are (i) theoretical, by exploring the extent to which various coupling approximations can accurately reproduce reference spectra and (ii) model-based, by exploring how various Earth parameters such as CMB topography, attenuation and S- and P-wave structures, and the seismic source solution may influence the spectra. We find that mode-pair coupling is insufficiently accurate, but coupling modes within a range of ±0.1 mHz produces acceptable spectra, compared to full coupling. This has important implications for splitting function measurements, which are computed under the assumption of isolated modes or at best, mode-pair or group coupling. We find that uncertainties in the P-wave velocity mantle model dominate compared to other model parameters. In addition, we also test several hypothetical models of mantle density structure against real data. These tests indicate that, with the low-frequency Stoneley mode spectral data considered here, it is difficult to make any firm statement on whether the large-low-shear-velocity-provinces are denser or lighter than their surroundings. We conclude that better constraints on long wavelength elastic mantle structure, particularly P-wave velocity, need to be obtained, before making further statements on deep mantle density heterogeneity. In particular, a dense anomaly confined to a thin layer at the base of the mantle (less than ∼100–200 km) may not be resolvable using the two Stoneley modes tested here, while the ability of higher frequency Stoneley modes to resolve it requires further investigations.
Boyden’s triad: the past, present and future
Authors: Zhang Min , Mao Ning , Wu Qingchen , Tie Hongtao , Ge Mingjian 
Published: October 2021

Abstract

OBJECTIVES
The B3 downwards-shifting malformation was first proposed by Boyden in 1950. Here, we report 14 cases of this malformation in the right lung and the first case of segmentectomy for this malformation.

METHODS
All patients with pulmonary lesions underwent three-dimensional computed tomography bronchography and angiography (3D-CTBA) between January 2019 and January 2020, prior to surgery. A consecutive 2356 patients were included, and 14 cases of this malformation were identified; bronchovascular patterns were analysed in each patient.

RESULTS
The incidence of this malformation was 0.6%. It was further divided into 3 types: over downwards-shift, partial downwards-shift and normal downwards-shift. The normal downwards-shift type was the most common (8/14), where B3 shifted downwards completely to merge with B4 + 5. In the partial downwards-shift (5/14), only part of the B3 shifted. In the over downwards-shift type (1/14), both B3 and B1b shifted downwards. A bifurcated right upper lobe （RUL) bronchus (B1 defective) was observed in 3 cases. The incidence of V1a, V1b, V2a, V2b, V2c, V3a, V3b and V3c was 100% (14/14). The incidence rates of A1, A3a and A3b were 100% (14/14). The incidence of A2 rec and A2 asc was 92.9% (13/14) and 71.4% (10/14), respectively.

CONCLUSIONS
The B3 downwards-shifting malformation or ‘Boyden’s triad’ is a rare anomaly. Anatomical exploration of this malformation is important for surgery.
Behavioural Compliance Theory
Authors: Peat Daniel , Fikfak Veronika , van der Zee Eva 
Published: October 2021

Abstract
Following in the wake of its social science siblings, international law scholarship is experiencing a ‘behavioural turn’. One particularly fruitful area in which to explore the utility of behavioural insights is compliance. The contributions to the present symposium represent some of the first efforts to explore how psychological influences may shape the compliance decision-making process and to study the theoretical and practical advantages offered by pursuing a behavioural analysis of compliance. This essay addresses several cross-cutting issues of importance. First, it outlines the epistemological stance that is implicit in behavioural approaches to compliance. It draws a parallel with economic theory, suggesting that the persistent dominance of rational choice theory in that field belies a teleological difference between international law and economics. The essay then turns to suggest how psychological influences both interact with and build on the material and normative considerations that are posited in existing theories to determine actors’ compliance-related behaviour. It continues to address the limitations of adopting a behavioural approach to compliance, from both a methodological and normative point of view. The final section provides a brief introduction to the pieces included in this symposium and outlines avenues for future research.
prose: a python framework for modular astronomical images processing
Authors: Garcia Lionel J , Timmermans Mathilde , Pozuelos Francisco J , Ducrot Elsa , Gillon Michaël , Delrez Laetitia , Wells Robert D , Jehin Emmanuël 
Published: October 2021

ABSTRACT
To reduce and analyse astronomical images, astronomers can rely on a wide range of libraries providing low-level implementations of legacy algorithms. However, combining these routines into robust and functional pipelines requires a major effort that often ends up in instrument-specific and poorly maintainable tools, yielding products that suffer from a low level of reproducibility and portability. In this context, we present prose, a python framework to build modular and maintainable image processing pipelines. Built for astronomy, it is instrument-agnostic and allows the construction of pipelines using a wide range of building blocks, pre-implemented or user-defined. With this architecture, our package provides basic tools to deal with common tasks, such as automatic reduction and photometric extraction. To demonstrate its potential, we use its default photometric pipeline to process 26 TESS candidates follow-up observations and compare their products to the ones obtained with AstroImageJ, the reference software for such endeavours. We show that prose produces light curves with lower white and red noise while requiring less user interactions and offering richer functionalities for reporting.
Regulation of star formation by large-scale gravitoturbulence
Authors: Nusser Adi , Silk Joseph 
Published: October 2021

ABSTRACT
A simple model for star formation based on supernova (SN) feedback and gravitational heating via the collapse of perturbations in gravitationally unstable discs reproduces the Schmidt–Kennicutt relation between the star formation rate (SFR) per unit area, ΣSFR, and the gas surface density, Σg, remarkably well. The gas velocity dispersion, σg, is derived self-consistently in conjunction with ΣSFR and is found to match the observations. Gravitational instability triggers ‘gravitoturbulence’ at the scale of the least stable perturbation mode, boosting σg at $\Sigma _{g}\gtrsim \, \Sigma _{g}^\textrm {thr}=50\, {\rm M}_\odot \, {\rm pc}^{-2}$, and contributing to the pressure needed to carry the disc weight vertically. ΣSFR is reduced to the observed level at $\Sigma _{g}\gtrsim \, \Sigma _{g}^\textrm {thr}$, whereas at lower surface densities, SN feedback is the prevailing energy source. Our proposed star formation recipes require efficiencies of the order of 1 per cent, and the Toomre parameter, Q, for the joint gaseous and stellar disc is predicted to be close to the critical value for marginal stability for $\Sigma _{g}\lesssim \, \Sigma _{g}^\textrm {thr}$, spreading to lower values and larger gas velocity dispersion at higher Σg.
SatGen – II. Assessing the impact of a disc potential on subhalo populations
Authors: Green Sheridan B , van den Bosch Frank C , Jiang Fangzhou 
Published: October 2021

ABSTRACT
The demographics of dark matter substructure depend sensitively on the nature of dark matter. Optimally leveraging this probe requires accurate theoretical predictions regarding the abundance of subhaloes. These predictions are hampered by artificial disruption in numerical simulations, by large halo-to-halo variance, and by the fact that the results depend on the baryonic physics of galaxy formation. In particular, numerical simulations have shown that the formation of a central disc can drastically reduce the abundance of substructure compared to a dark matter-only simulation, which has been attributed to enhanced destruction of substructure due to disc shocking. We examine the impact of discs on substructure using the semi-analytical subhalo model SatGen, which accurately models the tidal evolution of substructure free of the numerical disruption that still hampers N-body simulations. Using a sample of 10 000 merger trees of Milky Way-like haloes, we study the demographics of subhaloes that are evolved under a range of composite halo–disc potentials with unprecedented statistical power. We find that the overall subhalo abundance is relatively insensitive to properties of the disc aside from its total mass. For a disc that contains 5 per cent of Mvir, the mean subhalo abundance within rvir is suppressed by ${\lesssim }10{{\ \rm per\ cent}}$ relative to the no-disc case, a difference that is dwarfed by halo-to-halo variance. For the same disc mass, the abundance of subhaloes within 50 kpc is reduced by ${\sim }30{{\ \rm per\ cent}}$. We argue that the disc mainly drives excess mass-loss for subhaloes with small pericentric radii and that the impact of disc shocking is negligible.
The density distributions of cosmic structures: impact of the local environment on weak-lensing convergence
Authors: Ema Sonia Akter , Hossen Md Rasel , Bolejko Krzysztof , Lewis Geraint F 
Published: October 2021

ABSTRACT
Whilst the underlying assumption of the Friedman-Lemaître-Robertson-Walker (FLRW) cosmological model is that matter is homogeneously distributed throughout the universe, gravitational influences over the life of the universe have resulted in mass clustered on a range of scales. Hence we expect that, in our inhomogeneous Universe, the view of an observer will be influenced by the location and local environment. Here, we analyse the one-point probability distribution functions and angular power spectra of weak-lensing (WL) convergence and magnification numerically to investigate the influence of our local environment on WL statistics in relativistic N-body simulations. To achieve this, we numerically solve the null geodesic equations which describe the propagation of light bundles backwards in time from today, and develop a ray-tracing algorithm, and from these calculate various WL properties. Our findings demonstrate how cosmological observations of large-scale structure through WL can be impacted by the locality of the observer. We also calculate the constraints on the cosmological parameters as a function of redshift from the theoretical and numerical study of the angular power spectrum of WL convergence. This study concludes the minimal redshift for the constraint on the parameter Ωm (H0) is $z$ ∼ 0.2 ($z$ ∼ 0.6) beyond which the local environment’s effect is negligible and the data from WL surveys are more meaningful above that redshift. The outcomes of this study will have direct consequences for future surveys, where per cent-level-precision is necessary.
Accurate expression quantification from nanopore direct RNA sequencing with NanoCount
Authors: Gleeson Josie , Leger Adrien , Prawer Yair D J , Lane Tracy A , Harrison Paul J , Haerty Wilfried , Clark Michael B 
Published: October 2021

Abstract
Accurately quantifying gene and isoform expression changes is essential to understanding cell functions, differentiation and disease. Sequencing full-length native RNAs using long-read direct RNA sequencing (DRS) has the potential to overcome many limitations of short and long-read sequencing methods that require RNA fragmentation, cDNA synthesis or PCR. However, there are a lack of tools specifically designed for DRS and its ability to identify differential expression in complex organisms is poorly characterised. We developed NanoCount for fast, accurate transcript isoform quantification in DRS and demonstrate it outperforms similar methods. Using synthetic controls and human SH-SY5Y cell differentiation into neuron-like cells, we show that DRS accurately quantifies RNA expression and identifies differential expression of genes and isoforms. Differential expression of 231 genes, 333 isoforms, plus 27 isoform switches were detected between undifferentiated and differentiated SH-SY5Y cells and samples clustered by differentiation state at the gene and isoform level. Genes upregulated in neuron-like cells were associated with neurogenesis. NanoCount quantification of thousands of novel isoforms discovered with DRS likewise enabled identification of their differential expression. Our results demonstrate enhanced DRS isoform quantification with NanoCount and establish the ability of DRS to identify biologically relevant differential expression of genes and isoforms.
MarkovHC: Markov hierarchical clustering for the topological structure of high-dimensional single-cell omics data with transition pathway and critical point detection
Authors: Wang Zhenyi , Zhong Yanjie , Ye Zhaofeng , Zeng Lang , Chen Yang , Shi Minglei , Yuan Zhiyuan , Zhou Qiming , Qian Minping , Zhang Michael Q 
Published: October 2021

Abstract
Clustering cells and depicting the lineage relationship among cell subpopulations are fundamental tasks in single-cell omics studies. However, existing analytical methods face challenges in stratifying cells, tracking cellular trajectories, and identifying critical points of cell transitions. To overcome these, we proposed a novel Markov hierarchical clustering algorithm (MarkovHC), a topological clustering method that leverages the metastability of exponentially perturbed Markov chains for systematically reconstructing the cellular landscape. Briefly, MarkovHC starts with local connectivity and density derived from the input and outputs a hierarchical structure for the data. We firstly benchmarked MarkovHC on five simulated datasets and ten public single-cell datasets with known labels. Then, we used MarkovHC to investigate the multi-level architectures and transition processes during human embryo preimplantation development and gastric cancer procession. MarkovHC found heterogeneous cell states and sub-cell types in lineage-specific progenitor cells and revealed the most possible transition paths and critical points in the cellular processes. These results demonstrated MarkovHC’s effectiveness in facilitating the stratification of cells, identification of cell populations, and characterization of cellular trajectories and critical points.