bluuebunny/crossref_metadata_2025_split huggingface dataset:
INNOVATIVE TECHNOLOGIES AND TEACHING METHODS AT THE DEPARTMENT OF NORMAL PHYSIOLOGY
Authors: Nikolaenko O. , Datsyshyn P. 
Published: December 2021

Innovation methods are an effective educational technology due to its inherent qualities of interactivity, flexibility and integration of various types of educational information, as well as with the ability to take into consideration the individual characteristics of students and enhance their motivation.
The article discusses innovative teaching methods that are used in the system of the modern educational process. The characteristic features of the means, forms and methods of innovative teaching are determined, the specifics of their use in an interactive educational environment to improve the quality of student education at medical universities are revealed.
„Zaiste przyjdę niebawem” (Ap 22,20). Kilka refleksji nad eschatologią Apokalipsy św. Jana
Authors: Karczewski Marek 
Published: December 2021

Apokalipsa św. Jana zachwyca bogactwem i głębią treści eschatologicznych. Jednak aktualnie, w przestrzeni teologiczno-biblijnej refleksji naukowej tematy eschatologiczne nie są podejmowane zbyt często. Refleksje zawarte w tym artykule stanowią formę wskazówek o charakterze metodologicznym. Dotyczą one procesu odczytywania eschatologii Ap. Nie można jej interpretować w oderwaniu od badań o charakterze historyczno-literackim czy badań nad etyką ksiegi. Należy uwzględnić także specyficzny charakter profetyzmu Ap. Jednak centralne miejsce zajmują w Ap treści eschatologiczne. Aby interpretować je właściwie warto uwzględnić niektóre postulaty. Należą do nich: zwrócenie uwagi na dynamikę eschatologiczną Ap, uwzględnienie wieloznaczności niektórych symboli oraz odczytanie eschatologii księgi w relacji do jej oryginalnej chrystologii i eklezjologii.
IDADE E CRESCIMENTO DO BADEJO-MIRA, Mycteroperca rubra (BLOCH, 1973), NO SUDESTE DO BRASIL
Authors: Paiva Melquíades Pinto , Ximenes Carvalho Maria Odete , Fonteles Filho Antonio Adauto 
Published: December 2021

O badejo-mira, Mycteroperca rubra (Bloch, 1793), é um peixe demersal de mediana importância na região sudeste do Brasil, habitando fundos rochosos e arenosos da plataforma talude continentais. Idade e crescimento foram estudados com base na leitura de escamas coletadas em 152 exemplares de ambos os sexos, com comprimento total da faixa de 25,0 – 73,4 cm, no período de junho/1999 a maio/2000. A escama (S) cresce numa proporção isométrica com o comprimento individual (L) segundo a equação L = 4,2 + 79,9 S (r= 0,976; P<0,01), havendo periodicidade anual na formação dos anéis etários, com mudança de idade no bimestre novembro-dezembro. O valor médio dos comprimentos retrocalculados variou de 20,0 cm CT (grupo-de-idade I) a 72,3 cm CT (grupo-de-idade X). A equação de crescimento em comprimento (cm) é Lt=105,1 [1-e -106 (t+1,99)], cuja equação em peso (kg) é dada por Wt=14,0 [1-e-0,106(t+1,99)]2,958, ajustada através da regressão peso/comprimento: In W=-11,132+2,958 In L (r = 0.993; P<0,01). O coeficiente anual de mortalidade natural foi de 0,248. O badejo-mira tem baixo coeficiente de crescimento (K=0,106), elevado coeficiente de desempenho, ᶲ=3,068, elevada razão M/K=2,34 e grande longevidade, tmax=30,3 anos, características típicas de espécies carnívoras do 4º nível trófico.
Як підвищити ефективність профілактики порушень у роботі АЕС
Authors: Shevchenko I. , Pecheritsa O. , Boichuk V. , Sheiko Yu. 
Published: December 2021

Розкрито роль системи управління у створенні ефективної системи використання досвіду експлуатації. Показано типові проблеми щодо організації процесів виявлення подій на АЕС та звітності про них. Надано пропозиції з підвищення ефективності профілактики порушень у роботі АЕС за допомогою організації адекватних процесів виявлення подій та звітності про них, підвищення ефективності системи використання досвіду експлуатації.
Перевірка критеріїв безпеки змішаних завантажень ядерного палива для реакторів типу ВВЕР-1000
Authors: Shevchenko I. , Vorobyov Yu. 
Published: December 2021

Досліджуються теплогідравлічні аспекти моделювання змішаних активних зон (з кількома видами ядерного палива) з паливом ТВСА, ТВС-W та ТВС-WR. Проведено попередні оцінки критеріїв безпеки за максимальною температурою оболонок твелів у показних подіях аналізу проектних аварій (АПА) для ВВЕР-1000 з використанням розрахункового коду RELAP5/MOD3.2. Доведено, що максимальна температура оболонок твелів при введенні нового палива ТВС-W або ТВС-WR збільшується порівняно з температурою для ТВСА. При заклинюванні головного циркуляційного насосу і двосторонньому розриві холодної нитки головного циркуляційного трубопроводу (максимальна проектна аварія) попередні оцінки показали, що межа за максимальною температурою оболонок твелів 1200 °С не порушується. Отримані результати підтверджують необхідність подальшого аналізу теплогідравліки спільного використання ТВЗ ВВЕР‑1000 різних типів в аварійних режимах.
АПА енергоблока має бути доповнений дослідженням аварій для змішаних активних зон.
Порівняльний аналіз нейтронно-фізичних характеристик кампанії реактора з використанням різних наборів бібліотек ядерних даних для програмного продукту WIMSD5B
Authors: Galchenko V. , Mishyn A. 
Published: December 2021

Точність та якість результатів розрахунків як стаціонарних, так і перехідних процесів активної зони реактора, значною мірою залежать від процесу підготовки нейтронно-фізичних констант, який можна зробити коректнішим, оновивши бібліотеку ядерних даних програмного продукту.
У статті наведено порівняльний аналіз розрахунків активної зони ВВЕР-1000 за допомогою коду DYN3D із застосування константного забезпечення, підготованого кодом WIMSD5B за різними бібліотеками ядерних даних. Розглянуто можливість використання деяких бібліотек, випущених у рамках проекту модернізації бібліотек WIMSD5B, та проведено порівняння отриманих результатів.
Оцінка впливу невизначеності у вихідних даних на результати аналізу критичності ядерного палива
Authors: Bilodid Ye. , Kovbasenko Yu. 
Published: December 2021

Наведено отримані за допомогою розрахункового комплексу SCALE-4.4 результати розрахункової оцінки впливу технологічних
допусків на виготовлення та невизначеності вихідних даних з геометричного й матеріального складу елементів тепловидільної збірки (ТВЗ) ВВЕР-1000 на результати розрахунку критичності ядерного палива. Визначено найбільш консервативну сукупність параметрів у межах виробничої похибки з точки зору впливу на розмножувальні властивості паливної системи. Проаналізовано залежність розмножувальних властивостей від температури матеріалів ТВЗ.
Beyond the “Yellowstone Model:” The Origins of National Parks in Brazil and Argentina
Authors: Kaltmeier Olaf , Freitas Frederico 
Published: December 2021

Book Review
Kaltmeier, Olaf. National Parks from North to South: An Entangled History of Conservation and Colonization in Argentina. Inter-American Studies 34. Trier; New Orleans: WVT Wissenschaftlicher Verlag Trier; University of New Orleans Press, 2021.
Freitas, Frederico. Nationalizing Nature: Iguazu Falls and National Parks at the Brazil-Argentina Border. Latin American Studies 122. Cambridge; New York: Cambridge University Press, 2021.
KAJIAN SISTEM DRAINASE PERUMAHAN VALLE VERDE DI DESA PASIRHALANG
Authors: Hasan Fuad 
Published: December 2021

Drainase merupakan salah satu fasilitas dasar yang dirancang sebagai sistem guna memenuhi kebutuhan masyarakat dan merupakan komponen penting dalam perencanaan kota maupun perumahan. Perumahan Valle Verde yang berlokasi di Desa Pasir Halang Kecamatan Cisarua Kabupaten Bandung Barat perlu membuat kajian sistem drainase agar terhindar dari bencana banjir atau genangan air hujan. Tujuan dari kajian ini yaitu untuk mengetahui debit puncak dan kapasitas sistem drainase rencana. Dalam kajian ini analisis yang dilakukan adalah zona drainase, curah hujan, curah hujan rata-rata kawasan, pemilihan jenis distribusi hujan, perhitungan waktu konsenstrasi, menentukan besarnya intensitas hujan pada kala ulang 2 tahun, perhitungan debit banjir dan perhitungan kapasitas saluran rencana. Dari hasil analisis dan perhitungan tersebut diketahui bahwa untuk saluran drainase utama dapat menggunakan saluran terbuka dengan dimensi tinggi H = 0,22 m dan lebar dasar B = 0,25 m serta tinggi jagaan W = 0,20 m. Adapun untuk saluran yang berada didalam komplek, dapat menggunakan saluran tertutup dengan dimensi diameter D = 0.30 m.
IDENTIFIKASI KEASLIAN KARYA SENI RUPA DENGAN TEKNOLOGI IMAGE PROCESSING BERDASARKAN DETEKSI WARNA DAN TEKSTUR
Authors: Wahyu Ari Purno , Santosa Kaffah Imanuddin M R 
Published: December 2021

Sebuah karya merupakan hasil buah pikiran seseorang dalam menciptakan sebuah bentuk benda atau seni rupa, karya tersebut tidak hanya subuah benda dan bisa dalam bentuk ide kreatif dan edukasi yang berguna bagi kehidupan masyarakat, pada perkembangan dunia digital saat ini memiliki sebuah dampak-dampak positif dan negatif, sebagai contoh seseorang dapat dengan mudah mengambil karya seni rupa orang lain tanpa adanya credit atau pemberian izin dari kekayaan intelektual atau HAKI, tetapi hal ini tidak masalah jika bentuk seni rupa tersebut dibebaskan oleh pembuat seni rupa dan boleh untuk disebarluaskan, untuk mengatasi masalah pemalsuan karya seni tersebut dibuatlah sistem indentifikasi karya seni rupa berbasis image prosessing, dengan sistem identifikasi ini pengenalan karya seni rupa bisa dengan cara identifikasi tekstur yang secara detail bisa membaca bagian-bagian terpenting dari lukisan atau karya seni rupa tersebut dengan membaca pixel dan komposisi warna
SISTEM INFORMASI PERPUSTAKAAN BERBASIS SERVICE TECHNOLOGY UTAMA (STU) UNTUK DUKUNGAN PEMBELAJARAN ONLINE (E-LEARNING)
Authors: Wahyu Ari Purno , Sri Rejeki Diah , Agustine Merryam 
Published: December 2021

Perkembangan perpustakaan digital saat ini mulai berkembang pesat dan terus mengalami pembaharuan, perkembangan sistem informasi telah merubah tampilan perpustakaan yang tadinya hanya berupa barisan pajangan buku yang mungkin berdebu, kini berubah menjadi lebih interaktif dan disajikan secara lebih informatif dan lengkap, dimasa pandemi saat ini khususnya penyebaran covid-19 tidak menyurutkan rasa penasaran masyarakat terhadap informasi, baik informasi tentang covid-19 yang sudah sampai di rating tertinggi pada mesin mata pencaharian website, informasi yang dicari oleh masyarakat saat ini bisa berupa informasi tentang politik dan hiburan, dampak penyebaran covid mempengaruhi pula pada sektor pendidikan dimana beberapa sekolah dan universitas membatasi kehadiran siswa di kelas yang bertujuan untuk menghindari penyebaran covid sedangkan sistem dan proses pembelajaran harus berlangsung, Hal ini mendorong paradigma baru untuk membuat sistem pembelajaran berbasis online dengan memanfaatkan metode kuliah online dan materinya disajikan secara online berbasis teknologi informasi, hal ini menjadi sebuah dorongan bagi para ahli untuk berinovasi dalam mengembangkan sistem informasi perpustakaan yang berguna untuk menyajikan materi pembelajaran yang bersifat modul atau praktikum, sehingga berdasarkan permasalahan diatas diperlukan sistem perpustakaan yang tidak hanya mampu menyajikan materi tetapi juga sebagai media utama yang terintegrasi dengan jaringan, sehingga pada penelitian ini dikembangkan media informasi atau dikenal dengan sistem teknologi utama atau (STU) sistem ini mengintegrasikan sistem informasi yang memiliki kemampuan untuk menjadi pendukung program e-learning.
Levulinic Acid-Inducible and Tunable Gene Expression System for Methylorubrum extorquens
Authors: Sathesh-Prabu Chandran , Ryu Young Shin , Lee Sung Kuk 
Published: December 2021

Methylorubrum extorquens AM1 is an efficient platform strain possessing biotechnological potential in formate- and methanol-based single carbon (C1) bioeconomy. Constitutive expression or costly chemical-inducible expression systems are not always desirable. Here, several glucose-, xylose-, and levulinic acid (LA)-inducible promoter systems were assessed for the induction of green fluorescent protein (GFP) as a reporter protein. Among them, the LA-inducible gene expression system (HpdR/PhpdH) showed a strong expression of GFP (51-fold) compared to the control. The system was induced even at a low concentration of LA (0.1 mM). The fluorescence intensity increased with increasing concentrations of LA up to 20 mM. The system was tunable and tightly controlled with meager basal expression. The maximum GFP yield obtained using the system was 42 mg/g biomass, representing 10% of the total protein content. The efficiency of the proposed system was nearly equivalent (90%–100%) to that of the widely used strong promoters such as PmxaF and PL/O4. The HpdR/PhpdH system worked equally efficiently in five different strains of M. extorquens. LA is a low-cost, renewable, and sustainable platform chemical that can be used to generate a wide range of products. Hence, the reported system in potent strains of M. extorquens is highly beneficial in the C1-biorefinery industry to produce value-added products and bulk chemicals.
Association of IL33, IL1RL1, IL1RAP Polymorphisms and Asthma in Chinese Han Children
Authors: Wu Maolan , Zheng Xiangrong , Huang Juan , Hu Xiaolei 
Published: December 2021

Background: Genome-wide association studies have identified interleukin 33 (IL33), interleukin 1 receptor-like 1 (IL1RL1), interleukin 1 receptor accessory protein (IL1RAP) as asthma susceptibility loci in Europeans. IL33, IL1RL1, and IL1RAP constitute a ligand-receptor complex.Objective: We analyzed associations of asthma susceptibility, eosinophilic airway inflammation, and response to inhaled corticosteroid (ICS) with single nucleotide polymorphisms (SNPs) of 3 genes encoding IL33, IL1RL1, and its coreceptor IL1RAP in Chinese Han nationality children.Methods: A total of 153 non-asthmatic children and 265 asthmatic children who visited the Xiangya Hospital between September 2015 and August 2019 were recruited for this study. Pulmonary function tests, peripheral blood eosinophil counts (PBEC), and fractional exhaled nitric oxide (FeNO) tests were performed before treatment, and 3 months after treatment. Each participant’s DNA was extracted from the peripheral blood, and a Mass ARRAY system was used to genotype the SNPs.Results: The T allele of rs4742170 in IL33 was associated with a risk of higher FeNO at baseline, and no improvement in FeNO and airway hyperresponsiveness was found after ICS treatment. The A allele of rs10208293 and C allele of rs13424006 in IL1RL1 both were associated with lower susceptibility to asthma and lower FeNO. The TT genotype of rs1420101 and AA genotype of rs4142132 in IL1RL1 were associated with a greater probability of improvement in PBEC after ICS treatment.Conclusion: IL33-IL1RL1-IL1RAP complex polymorphisms are associated with childhood asthma susceptibility, eosinophilic airway inflammation, and ICS response in Chinese Han children in Hunan. We speculate that IL33-IL1RL1-IL1RAP complex polymorphisms affect the development of asthma, airway inflammation, and subsequent ICS response in childhood.
Zircon of Triassic Age in the Stuttgart Formation (Schilfsandstein)—Witness of Tephra Fallout in the Central European Basin and New Constraints on the Mid-Carnian Episode
Authors: Zeh Armin , Franz Matthias , Obst Karsten 
Published: December 2021

The Carnian Stuttgart-Formation (Schilfsandstein) of the Central European Basin contains relics of Triassic volcanic detritus in form of euhedral zircon grains and authigenic analcime. Multiple LA-ICP-MS spot analyses of single zircon crystals from an outcrop near Heilbronn (SW Germany) yielded weighted average 206Pb/238U ages between 250 and 230 Ma, providing evidence for tephra fallout in the southern part of the Central European Basin related to Olenekian, Anisian–Ladinian and Carnian volcanic activity. The tephra was probably transported by monsoonal circulations from volcanic centres of the NW Tethys to the Central European Basin. The four youngest zircon crystals gave a weighted average 206Pb/238U age of 231.1 ± 1.6 Ma (10 analyses), which is interpreted to date syn-depositional tephra fallout into the fluvial Lower Schilfsandstein Member of the Stuttgart Formation. This new maximum depositional age provides the first evidence that deposition of the Stuttgart Formation, which represents the type-example of the mid-Carnian episode, a global episode of enhanced flux of siliciclastic detritus and related environmental perturbations, occurred during the Tuvalian 2 substage at ca. 231 Ma, about 3 million years later than suggested by previous correlations. Zircon grains with weighted average 206Pb/238U ages of 236.0 ± 1.2 Ma (n = 17) and 238.6 ± 1.5 Ma (n = 6) and 206Pb/238U ages between 241 ± 6 and 250 ± 3 Ma point to the presence of tephra in early Carnian to Olenekian strata of the Keuper to Buntsandstein Groups. Traces of these reworked tephra were incorporated into the Stuttgart Formation due to fluvial erosion in the southern Central European Basin and at its margins.
Early Versus Routine Oral Glucose Tolerance Test in Women With Intermediate Hyperglycemia at First Prenatal Visit: A Retrospective Cohort Study in China
Authors: Ye Yunzhen , Qin Kaizhou , Xiong Yu , Wu Jiangnan , Zhou Qiongjie , Xiao Xirong , Li Xiaotian 
Published: December 2021

Background and ObjectivesIntermediate hyperglycemia in the first half of pregnancy, defined as a fasting plasma glucose level between 5.1- 6.9 mM, increases the risk of gestational diabetes mellitus, but clinical evidence for further management is lacking. We aim to evaluate the effectiveness of an early oral glucose tolerance test (OGTT) followed by the identification of intermediate hyperglycemia on pregnancy outcomes in real world setting.Subjects and MethodsA retrospective cohort study was conducted at the Obstetrics and Gynecology Hospital, Shanghai, China, between 2013 and 2017. Women with intermediate hyperglycemia at the first prenatal visit were identified and underwent an immediate (within one week) or a routine OGTT (24-28 gw) according to their wishes and received nutrition and exercise advice. Women diagnosed of gestational diabetes (GDM) were managed by standard interventions. Primary outcome was larger for gestational age (LGA). Secondary outcomes were primary cesarean delivery, preterm birth, shoulder dystocia or forceps delivery, preeclampsia, neonatal hypoglycemia, hyperbilirubinemia, and low Apgar score. Logistic regressions with or without a further propensity score-matched analysis were performed.ResultsAmong 42406 women involved, 1104 (2.6%) with intermediate hyperglycemia at the first prenatal visit were identified, of whom 176 (15.9%) underwent an early OGTT and 741 (67.1%) received a routine OGTT. Logistic regression showed that an early OGTT was not significantly associated with an altered risk of LGA (adjusted OR 1.13, 95% CI 0.73-1.75) but was related to an increased odds for neonatal hyperbilirubinemia (adjusted OR 2.89; 95% CI 1.55-5.37). No significant associations were observed for other secondary outcomes. These trends remained consistent in propensity score-matched models.ConclusionsOur data from a real-world setting did not support that an early OGTT among women with intermediate hyperglycemia at the first prenatal visit improved pregnancy outcomes.
Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147
Authors: Zisman Devy , Safieh Mirna , Simanovich Elina , Feld Joy , Kinarty Amalia , Zisman Liron , Gazitt Tal , Haddad Amir , Elias Muna , Rosner Itzhak , Kaly Lisa , Rahat Michal A. 
Published: December 2021

BackgroundAngiogenesis is a major contributor to the development of inflammation during Rheumatoid arthritis (RA), as the vascularization of the pannus provides nutrients and oxygen for the infiltrating immune cells and proliferating synoviocytes. Tocilizumab (TCZ) is an anti-IL-6 receptor antibody that is used in the treatment of RA patients, and has been shown to exert anti-inflammatory effects. However, its effects on angiogenesis are not fully elucidated, and the molecular mechanisms regulating this effect are unknown.MethodsWe evaluated the concentrations of several pro- and anti-angiogenic factors and the expression levels of several microRNA molecules that are associated with RA and angiogenesis in serum samples obtained from 40 RA patients, before and 4 months after the initiation of TCZ treatment. Additionally, we used an in vitro co-culture system of fibroblasts (the HT1080 cell line) and monocytes (the U937 cell line) to explore the mechanisms of TCZ action.ResultsSerum samples from RA patients treated with TCZ exhibited reduced circulating levels of EMMPRIN/CD147, enhanced expression of circulating miR-146a-5p and miR-150-5p, and reduced the angiogenic potential as was manifested by the lower number of tube-like structures that were formed by EaHy926 endothelial cell line. In vitro, the accumulation in the supernatants of the pro-angiogenic factors EMMPRIN, VEGF and MMP-9 was increased by co-culturing the HT1080 fibroblasts and the U937 monocytes, while the accumulation of the anti-angiogenic factor thrombospondin-1 (Tsp-1) and the expression levels of miR-146a-5p were reduced. Transfection of HT1080 cells with the miR-146a-5p mimic, decreased the accumulation of EMMPRIN, VEGF and MMP-9. When we neutralized EMMPRIN with a blocking antibody, the supernatants derived from these co-cultures displayed reduced migration, proliferation and tube formation in the functional assays.ConclusionsOur findings implicate miR-146a-5p in the regulation of EMMPRIN and propose that TCZ affects angiogenesis through its effects on EMMPRIN and miR-146a-5p.
Allogeneic Vγ9Vδ2 T-Cell Therapy Promotes Pulmonary Lesion Repair: An Open-Label, Single-Arm Pilot Study in Patients With Multidrug-Resistant Tuberculosis
Authors: Liang Juan , Fu Liang , Li Man , Chen Yuyuan , Wang Yi , Lin Yi , Zhang Hailin , Xu Yan , Qin Linxiu , Liu Juncai , Wang Weiyu , Hao Jianlei , Liu Shuyan , Zhang Peize , Lin Li , Alnaggar Mohammed , Zhou Jie , Zhou Lin , Guo Huixin , Wang Zhaoqin , Liu Lei , Deng Guofang , Zhang Guoliang , Wu Yangzhe , Yin Zhinan 
Published: December 2021

The WHO’s “Global tuberculosis report 2020” lists tuberculosis (TB) as one of the leading causes of death globally. Existing anti-TB therapy strategies are far from adequate to meet the End TB Strategy goals set for 2035. Therefore, novel anti-TB therapy protocols are urgently needed. Here, we proposed an allogeneic Vγ9Vδ2 T-cell-based immunotherapy strategy and clinically evaluated its safety and efficacy in patients with multidrug-resistant TB (MDR-TB). Eight patients with MDR-TB were recruited in this open-label, single-arm pilot clinical study. Seven of these patients received allogeneic Vγ9Vδ2 T-cell therapy adjunct with anti-TB drugs in all therapy courses. Cells (1 × 108) were infused per treatment every 2 weeks, with 12 courses of cell therapy conducted for each patient, who were then followed up for 6 months to evaluate the safety and efficacy of cell therapy. The eighth patient initially received four courses of cell infusions, followed by eight courses of cell therapy plus anti-MDR-TB drugs. Clinical examinations, including clinical response, routine blood tests and biochemical indicators, chest CT imaging, immune cell surface markers, body weight, and sputum Mycobacterium tuberculosis testing, were conducted. Our study revealed that allogeneic Vγ9Vδ2 T cells are clinically safe for TB therapy. These cells exhibited clinical efficacy in multiple aspects, including promoting the repair of pulmonary lesions, partially improving host immunity, and alleviating M. tuberculosis load in vivo, regardless of their application in the presence or absence of anti-TB drugs. This pilot study opens a new avenue for anti-TB treatment and exhibits allogeneic Vγ9Vδ2 T cells as promising candidates for developing a novel cell drug for TB immunotherapy.Clinical Trial Registration(https://clinicaltrials.gov/ct2/results?cond=&amp;term=NCT03575299&amp;cntry=&amp;state=&amp;city=&amp;dist=) ( NCT03575299).