bluuebunny/crossref_metadata_2025_split huggingface dataset:
DYNAMICS OF INDICES OF LEFT VENTRICULAR-ARTERIAL COUPLING IN PATIENTS WITH HYPERTENSION AFTER ACUTE MYOCARDIAL INFARCTION
Authors: Oleynikov Valentin , Salyamova Lyudmila , Kvasova Olga , Galimskaya Vera , Fadeeva Svetlana 
Published: April 2021

Objective:
To study the dynamics of left ventricular-arterial coupling (LVAC) indices in patients with arterial hypertension (AH) after STEMI, depending on the presence or absence of rapidly progressing left ventricular (LV) remodeling.

Design and method:
The study included 71 patients (mean age 51.4 ± 8.4 years) with hypertension after STEMI. Echocardiography was performed at the 7–9th day and 24th, 48th weeks after STEMI (MyLab, Esaote, Italy) with the determination of EDV, its index (EDVi) and calculation of LVAC indices: arterial elastance (Ea), LV elastance (Ees), LVAC index (Ea/Ees). All patients received STEMI treatment for 48 weeks.

Results:
According to the EDVi dynamic during the 24 weeks, the patients were divided into two groups: group 1 - 30 people with rapidly progressive LV remodeling (increase in the EDVi > 20%); group 2 - 41 people without LV remodeling (EDVi dynamics < 20%). The following dynamics of LVAC indices was revealed: in group 1 Ea initialy was 2.0[95%CI 1.8;2.2], after 24 weeks - 1.6 [95%CI 1.4;1.8] (p = 0.0003), 48 weeks - 1.8[95%CI 1.5;2.0] (p = 0.0007); in group 2, respectively, 1.9[95%CI 1.7;2.1], 1.9[95%CI 1.7;2.0] (p = 0.46), 1.8[95%CI 1.7;1.9] (p = 0.27). Ees in the 1st group initially 1.8[95%CI 1.4;2.3], after 24 weeks - 1.2[95%CI 0.9;1.6] (p = 0.0002), 48 weeks - 1.3[95%CI 1.1;1.6] (p = 0.0001); in group 2 - 2.0[95%CI 1.9;2.2], 2.2[95%CI 2.0;2.4] (p = 0.08), 2.3[95%CI 2.1;2.5] (p = 0.009). In the 1st group the Ea/Ees index initially corresponded to normal values: 1.2[95 CI 1.0;1.4], followed by an increase after 24 weeks to 1.4 [95% CI 1.1; 1.6] (p = 0.007) and after 48 weeks - 1.4[95%CI 1.2;1.7] (p = 0.002). In the 2nd group, a decrease of Ea/Ees was revealed: initially - 1.0[95%CI 0.9;1.1], after 24 weeks - 0.9[95%CI 0.8;0.9] (p = 0.02), 48 weeks - 0.8[95%CI 0.7;0.9] (p = 0.002).

Conclusions:
In the group of patients, against the background of the development of rapidly progressive LV remodeling after STEMI in combination with hypertension, a pathological increase in the LVAC index was revealed due to a more pronounced decrease in left ventricular elastance, which reflects impaired homeostasis of the cardiovascular system.
OBSTRUCTIVE SLEEP APNEA SYNDROME AS CARDIOVASCULAR RISK FACTOR ASSOCIATED WITH HYPERURICEMIA
Authors: Skvortsova Ruth , Anisimova Kristina , Pavlova Viktoria , Obukhova Anna , Popova Kristina , Vaulina Daria , Razumovskaya Tatiana , Rabik Ulia , Kazachenko Alexander , Balandov Stanislav , Vasilevsky Dmitry , Kulikov Alexander 
Published: April 2021

Objective:
To assess the relationship between OSAS and uric acid levels.

Design and method:
54 patients with a BMI of more than 30 kg/m2, mean age 44.8 ± 11.4 years, men 14 and women 40 were examined. All patients underwent polysomnography with registration of apnea/hypopnea index (AHI) and mean saturation (SpO2m) and were evaluate for uric acid levels in the blood.

Results:
Patients were divided into 2 groups depending on AHI: 1) gr_1 (n = 33) with AHI < 15/hour, which corresponds to the norm and mild OSAS; gr_2 (n = 21) with AHI > / = 15 / hour, which corresponds to the middle-severe OSAS. In patients gr_1 AHI 4.1/hour ± 3.7 and in patients gr_2 - 50.5/hour ± 31.1, respectively. BMI was not associated with AHI. The level of uric acid was significantly higher in gr_2 - 481 ± 81 μmol/L than in gr_1 - 390 ± 84 μmol/L (p < 0.001). In addition, a correlation was found between the level of SpO2m and uric acid (p < 0.01).

Conclusions:
Hyperuricemia is an independent risk factor for hypertension and cardiovascular events.
According to the results of our examination, patients with OSAS have a more frequent development of hyperuricemia. Respectively, OSAS, adjusted for BMI, can be considered as an independent adverse risk factor for the development of cardiovascular events. Timely detection of OSAS will allow to start specialized treatment on time, improve the cardiovascular prognosis of this group of patients and, thus, reduce overall health care costs.
EXPOSURE TO CHILDHOOD ABUSE IS ASSOCIATED WITH HYPERTENSION IN SOUTH AFRICAN WOMEN
Authors: Nguyen Kim , Kengne Andre , Abrahams Naeemah , Jewkes Rachel , Mhlongo Shibe , Peer Nasheeta 
Published: April 2021

Objective:
Childhood abuse (CA), which affected at least half of the children globally, has increasingly been shown to adversely impact physical health in adulthood. We investigated the associations of CA with hypertension in 18–40-year-old South African women in the Kwazulu-Natal Province of South Africa, using the baseline data of the Rape Impact Cohort Evaluation study.

Design and method:
In this cross-sectional study, CA was defined as sexual, physical and emotional abuse, and/or parental neglect. Hypertension was defined as blood pressure equal or above 140/90 mmHg or known hypertension on treatment. Logistic regression models examining the associations between childhood abuse and hypertension adjusted for traditional hypertension risk factors, rape exposure, HIV-infection, other traumatic exposures, depressive symptom scores and post-traumatic stress disorder (PTSD) scores. The mediating effects of hypertension risk factors on the associations were also explored.

Results:
Among 1797 women, median age 24 years (25th-75th: 21–29 years), the prevalence of exposure to CA was significantly higher in those with compared to without hypertension: any CA: 70.9% vs 57.2%, sexual abuse: 20.9% vs 12.4%, physical abuse: 51.8% vs 41.5%, emotional abuse: 40% vs 27.6% and parental neglect: 35% vs 25.7%. In the regression analyses, exposures to any CA (adjusted odds ratio: 1.04; 95%CI: 1.01–1.07; p = 0.014), sexual abuse (1.05; 1.01–1.10; p = 0.026) and emotional abuse (1.05; 1.01–1.08; p = 0.009) were associated with hypertension. The associations of physical abuse (1.03; 1.00–1.06; p = 0.074) and parental neglect (1.03; 0.99–1.06; p = 0.132) with hypertension were borderline to non-significant. Increasing frequency of CA and exposure to multiple types of CA were associated with higher odds of hypertension. The observed associations were partially mediated by alcohol consumption, other trauma experienced, depression and PTSD.

Conclusions:
The associations of CA with hypertension highlight that, while CA must be prevented, effective mental health interventions are needed to prevent hypertension in women exposed to CA.
FIRST RESULTS OF THE NEW HUNGARIAN HYPERTENSION REGISTRY: NUMBER OF DAILY MEASUREMENTS AND PROPORTION OF PATIENTS IN DIFFERENT BLOOD PRESSURE CATEGORIES
Authors: Nemcsik János , Habony Norbert , Ábrahám György , Farsang Csaba , Simon Attila , Benczúr Béla , Páll Dénes , Járai Zoltán 
Published: April 2021

Objective:
Hypertension is a major public health problem and its proper diagnosis and treatment are crucial points of cardiovascular morbidity and mortality reduction. The aim of the new Hungarian Hypertension Registry is to evaluate the features of blood pressure measurement practice of family physicians and hypertension care specialists and to overview the blood pressure values measured during everyday practice.

Design and method:
Omron M3 IT devices are located for four months periods in repeated times between October 2018 and October 2023 to family physician practices and to hypertension outpatient clinics. Blood pressure values are transmitted online to an evaluating center using the Medistance system of Omron.

Results:
Until now 1,691 family physicians, 111 internists, 112 cardiologists and 12 hypertension specialists were being involved into the study. During 4 four-months long evaluation periods between October 2018 and October 2020, 1 701 927 blood pressure measurements were registered. The daily average number of the measurements in the three periods were 3.5, 4.8, 5.4 and 3.6, respectively. Following the ESH diagnostic criteria, the proportion of subjects in optimal, normal and high-normal blood pressure categories were 13.4%, 13.4% and 17%, respectively. The proportion of patients in stage 1, stage 2 and stage 3 hypertension categories were 32.1%, 17% and 7.1%, respectively. The average systolic blood pressure values in family physician practices with more than 2500 patients were higher compared with practices with less, than 1500 patients (141.8 mmHg versus 139.84 mmHg, respectively).

Conclusions:
In conclusions, the low daily average number of blood pressure measurements refers for limited blood pressure screening capacity of the Hungarian family physicians. In practices with more patients the blood pressure is generally less controlled. These results suggest the need for reconsideration of the blood pressure measurement guidelines and the further promotion of home blood pressure measurement.
IMPROVED PREGNANCY OUTCOME IN WOMEN WITH GESTATIONAL HYPERTENSION AS A RESULT OF OBSTETRICIAN AND CARDIOLOGIST TEAMWORK
Authors: Neagu Manuela , Patrascu Natalia , Vintila Ana Maria , Vintila Vlad 
Published: April 2021

Objective:
Gestational hypertension remains the leading cause of maternal, fetal and neonatal morbidity and mortality worldwide.
In spite of ESH and ESC guidelines (2011–2013) regarding the use of low-dose aspirin for preventing poor obstetric outcome due to preeclampsia and in spite of the many studies involving aspirin published by FMF our national obstetrical guidelines didn’t mentioned aspirin prophylaxis until 2018. So for many years the first to recommend aspirin to a pregnant women was the cardiologist and not the obstetrician.
To asses the outcome of the second pregnancy in women of high risk for early onset/sever preeclampsia after introducing low dose aspirin in early gestation.

Design and method:
A case series of secundiparous women (2017–2019), with history of poor maternal and fetal outcome because of sever preeclampsia (2014–2015), was assessed after starting 150 mg of aspirin daily from the onset of the second gestation until week 36. In this retrospective study no women with diabetes, chronic hypertension, obesity, any type of autoimmune disease, kidney disease or multiple gestation were included. The followed-up of these patients was done both by the obstetrician and cardiologist. The evaluation criteria for assessing the obstetrical outcome were: gestational age at onset of hypertension, Doppler velocity indices and non-stress test results, time and mode of delivery, birth weight, Apgar score, length of hospitalization; all compared to the outcomes of the first pregnancy.

Results:
None of the patients developed severe preeclampsia or early onset hypertension, but all of them de late onset gestational hypertension or mild preeclampsia needing antihypertensive therapy. There were no preterm babies, all women delivered at term, week 38–39, by elective C-section or after induced labor. There were no cases of intrauterine growth restriction, no signs of fetal distress according to Doppler ultrasound examination or on CTG monitoring. The Apgar score was no lower than 8 and there was no NICU admission. Antihypertensive therapy was no longer required after birth and all mothers began brestfeeding.

Conclusions:
This improved obstetrical outcome was the result of team approach in the management of pregnant women with high risk of hypertensive disorders.
SERVICE AVAILABILITY, AND READINESS OF PRIMARY CARE HEALTH FACILITIES TO OFFER HYPERTENSION DIAGNOSIS SERVICES IN WAKISO DISTRICT – UGANDA
Authors: Nanono Jackline , Kasujja Francis Xavier , Rutebemberwa Elizeus 
Published: April 2021

Objective:
To determine the availability of hypertension diagnostic services, the readiness of health center IIs, health-facility associated factors, facilitators and the barriers in provision of hypertension diagnosis services.

Design and method:
A cross sectional study design was used, 79 health facilities were sampled randomly. Health facility checklists were administered to the health facility in-charges, individual semi-structured questionnaires to health workers and key informant interview guides to a purposive sample of health workers and personnel at Wakiso district. Chi-square and the Fisher's exact test were used to assess associations between categorical variables. Service availability was measured by assessing the provision of blood pressure (BP) measurements, weight measurements and the scheduling of regular check-ups. Readiness was measured by assessing the availability and functional status of the BP apparatus and other hypertension diagnostic equipment and supplies, and yet also the presence of a trained health care provider.

Results:
The majority (86%) of the primary care health facilities offered all the hypertension diagnosis services and 13% of the health centre IIs were ready to offer comprehensive hypertension diagnosis services. There were significant associations between the level of the health facility; BP measurements (P = 0.005), managing newly diagnosed cases of hypertension (P = 0.001), and scheduling of regular check-ups (P = 0.003). The health workers were facilitated by the availability of equipment, primary health care funds and implementing partners, whereas the barriers faced were the lack of equipment, availability of non-functional equipment, delays in receiving trainings’ and inadequate staffing.

Conclusions:
The study showed that the majority of the health facilities offered hypertension diagnosis services including the Health Centre IIs which are lowest in the tier. There were gaps in the readiness to offer hypertension diagnosis services, thus equipment should be routinely calibrated, replaced and routine continuous medical education sessions should be provided to the health workers.
CONTENT, STRUCTURE AND DELIVERY CHARACTERISTICS OF YOGA INTERVENTIONS FOR MANAGING HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMISED CONTROLLED TRIALS
Authors: Nalbant Gamze , Lewis Sarah , Chattopadhyay Kaushik 
Published: April 2021

Objective:
The objective of the systematic review was to synthesise the content, structure and delivery characteristics of yoga interventions used for managing hypertension.

Design and method:
The Joanna Briggs Institute guidelines were followed in conducting the systematic review. This systematic review included randomised controlled trials (RCTs) conducted among adults (18 years and older) with hypertension. Studies in line with the classification of hypertension by the International Society of Hypertension/American Society of Hypertension were eligible. RCTs reporting at least one of the major components of yoga (i.e., asana (yogic poses), pranayama (breathing practices), and dhyana (meditation) and relaxation practices) and comparing them with no intervention or any intervention (e.g., lifestyle modification and pharmacotherapy) were eligible. Nineteen databases were searched for published and unpublished studies without any date and language restrictions.

Results:
The literature search yielded 11,629 records. Thirty-one RCTs (evaluating 35 yoga interventions) met the inclusion criteria, and 2837 participants were included. Overall, the methodological quality of these studies was found to be low. Yoga interventions improved systolic and diastolic blood pressure (SBP, DBP) compared to control group (mean difference -6.69 and -2.68; 95% CI -9.32 to -4.07 and -4.11 to -1.24, respectively). Sixteen, 13 and 18 interventions were effective in improving SBP, DBP or either, respectively. Twelve out of 18 interventions incorporated all the three major components of yoga and allocated similar durations to each component. The most common duration and frequency of effective interventions was 45 min/session (in 5 interventions), 3 or 6 or 7 days/week (in 12 interventions) and 12 weeks (in 10 interventions). Eleven were centre-based, seven were both centre- and home-based, and 15 were supervised.

Conclusions:
Yoga interventions seem to be effective in managing hypertension. High-quality RCTs, utilising the synthesised content, structure and delivery characteristics of effective yoga interventions, should be conducted.
DEVICE-SPECIFIC EMPIRICAL CORRECTION EQUATIONS FOR ACCURATE NON-INVASIVE ESTIMATION OF CENTRAL SYSTOLIC BLOOD PRESSURE IN CHILDREN AND ADOLESCENTS
Authors: Mynard Jonathan , Harrington Hilary , Smolich Joseph , Avolio Alberto , Cheung Michael 
Published: April 2021

Objective:
Central systolic blood pressure (cSBP) represents the load experienced by the heart and other central organs, and differs from brachial blood pressure due to pulse pressure amplification (PPA). Two widely-used automated devices (SphygmoCor XCEL and Mobil-O-Graph) incorporate algorithms to estimate cSBP and PPA, but in the recent KidCoreBP study, neither passed validation against invasively-measured cSBP in children and adolescents (J Hypertens 38:821–828, 2020). We investigated whether empirical correction equations, using information provided by these automated devices and basic demographics, could provide cSBP and PPA estimates with acceptable accuracy (error mean < 5 mmHg) and precision (error standard deviation < 8 mmHg).

Design and method:
Using data from the KidCoreBP study (n = 62, SphygmoCor; n = 52, Mobil-O-Graph), stepwise linear regression was used to identify empirical correction equations for predicting cSBP and PPA. Input variables included all blood pressures and pulse wave analysis indices provided by the device, as well as age, sex, height and weight. A leave-one-out cross-validation was then conducted to quantify accuracy and precision.

Results:
The empirical equations substantially improved estimation of cSBP (–0.1 ± 5.1 corrected vs 7.9 ± 6.8 mmHg uncorrected, SphygmoCor; and 0.03 ± 7.6 vs 5.7 ± 10.3 mmHg, Mobil-O-Graph) and PPA (0.0 ± 4.5 vs 4.2 ± 5.1 mmHg; and 0.0 ± 4.7 vs 6.8 ± 8.4 mmHg).

Conclusions:
This is the first study to demonstrate acceptable accuracy and precision of cSBP and PPA estimated using automated devices in children and adolescents, when compared to high fidelity invasive measurements. Device-specific empirical correction equations may overcome the present inaccuracy and/or imprecision of available devices.
INTEGRATED HYPERTENSION AND DIABETES MELLITUS TYPE II TREATMENT AND CARE AMONG PEOPLE LIVING WITH HIV/AIDS ATTENDING CARE AND TREATMENT CENTER IN DAR ES SALAAM, TANZANIA IN 2020
Authors: Musyani Atuganile , Mosi Grace , Kinyenje Erik , Mizinduko Mucho , Kishimba Rogath , Shimwela Meshack , Thomson-Paul Angela 
Published: April 2021

Objective:
Persons living with HIV/AIDS (PLHIV) now live longer due to the advancement of HIV care rendering them at increased risk of developing Non-Communicable diseases (NCDs). Despite having strong HIV/AIDS care programs, Tanzania lacks effective integration of NCDs care among PLHIV. This project aimed at implementing and evaluating hypertension (HTN) and Type-2 diabetes mellitus (T2DM) prevention, treatment, and care efforts among PLHIV attending care and treatment clinic.

Design and method:
The project was a facility-based intervention that included a collection of demographic, clinical, and laboratory data. A STEPwise approach of the STEPS surveillance tool for NCDs from the WHO was used to collect information from participants. A cohort of patients diagnosed with HTN and T2DM was created and followed up for four months to ascertain for disease control rates. Patient follow-up included health education, medical checkup, and consultation. Descriptive, bivariate, and multivariate logistic regression analyses were done to determine the association between hypertension and risk factors. A paired t-test was done to see the significance of the intervention.

Results:
A total of 335 patients were included in the assessment for the risk factors for hypertension and T2DM in which the prevalence was found to be 21.32% and 2.70% respectively. With multivariate analysis, obesity (AOR = 4.04 95%CI 1.72–9.52) and diabetes (AOR 5.58 95%CI 1.05–29.53) were the risk factors for having hypertension. Being employed in private or government organization and Stage 4 four of HIV disease at diagnosis were found to be at reduced risk of getting hypertension. A paired T-test showed significance difference in mean systolic blood pressure (t = 3.07 w/df = 81, p < 0.01) and diastolic blood pressure (t = 2.91 w/df = 81, p < 0.01) while there was no difference in mean fasting blood glucose level (p = 0.82) and body mass index p = 0.08).

Conclusions:
The magnitude of NCD risk factors is significantly higher among PLHIV and there was a significant change in HTN after three months of project implementation. NCDs integration among PLHIV is possible and should be initiated and strengthened.
BLOOD PRESSURE IN A POPULATION OF A RURAL AREA OF RWANDA: PRELIMINARY DATA
Authors: Muggli Franco , Parati Gianfranco , Suter Paolo , Bianchetti Mario , Radovanovic Dragana , Umulise Alice , Muvunyi Bienvenu , Ntaganda Evariste 
Published: April 2021

Objective:
Arterial hypertension likely affects millions of people in Africa and is the most important cause of heart disease and stroke. In Sub-Saharan Africa, the burden of hypertension is a rapid growing health threat. The objective of our study was to perform a screening of the local population living in the rural area of the District of Nyaruguru (Rwanda) to determine the prevalence of high blood pressure (BP).

Design and method:
Between February and July 2020, instructed health care workers collected some anthropometric data (such as height and weight) and measured BP three times in sitting position with validated oscillometric device (OMRON HEM-7322U).

Results:
A total of 7336 subjects participated to the screening, with median age of 32 (IQR 21,47) years; 4053 (55%) were female, age 35 (23, 49) years; 3283 (45%) were male, age 30 (20, 44) years (p < 0.001). Body Mass Index was 20.7 (19.0, 22.3) in males and 21.8 (20.0, 23.8) in females (p < 0.001). The mean of the last two BP measurements were 119.5 ± 15.2 mm Hg. Males had a higher systolic blood pressure (SBP) 120.1 ± 14.0 mm Hg comparing to female 118.6 ± 16.1 (p < 0.001.) Considered SBP equal or more than 140 mm Hg for the diagnosis of hypertension 642 subjects (8.8%) had high BP values, without differences between males (8.4%) und female (9.0%); p = 0.36.

Conclusions:
Surprisingly, in a very rural peripheral region where the average age of the inhabitants is relatively low, about 9% of the subjects examined have abnormal BP values. These data confirm the need to implement also in rural areas of Rwanda an adequate strategy for the prevention, diagnosis and treatment of hypertension.