bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between genetic characteristics and treatment failure when switching from biologic disease-modifying antirheumatic drugs/Janus kinase inhibitors in patients with rheumatoid arthritis
Authors: Bobkova A. O. , Lila A. M. , Karateev A. E. , Guseva I. A. , Samarkina E. Yu. , Shabatina M. V. , Konovalova N. V. , Varlamov D. A. 
Published: February 2025

Genetic polymorphisms in several genes can determine the response to therapy with biologic disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitors (JAKi) in rheumatoid arthritis (RA).Objective: to determine the association between polymorphisms of genes of IL-6 (rs1800795), IL-6R (rs2228145), TNFAIP3 (rs10499194, rs6920220), TNFα (rs1800629), CTLA-4 (rs231775), TNFSF13B (BAFF) (rs9514828), KCNS1 (rs734784), COMT (rs4633), IL-10 (rs1800872) and STAT4 (rs7574865) and inadequate response when switching RA patients from an ineffective bDMARD and/or JAKi to another bDMARD or JAKi.Material and methods. The study group consisted of 94 patients with RA (85.1% women, mean age 47.2±13.8 years) with moderate or high disease activity that persisted despite therapy with a bDMARD/JAKi. All patients were switched to another bDMARD or JAKi, including 12 (12.8%) to a tumor necrosis factor-α inhibitor, 27 (28.7%) to an interleukin-6 inhibitor, 46 (48.9%) to rituximab and 9 (9.6%) to a JAKi. After six months, RA activity was assessed using the DAS28-CRP, SDAI and CDAI indices. Two groups of patients were identified: those who responded to treatment (n=47), achieved remission or low activity (DAS28-CRP ≤3.2, SDAI ≤11, CDAI < 10), and those who did not respond to treatment (n=47) and had moderate/high activity according to the aforementioned indices. All patients underwent genotyping of the polymorphisms of the indicated genes using the polymerase chain reaction method.Results and discussion. Carrying the mutant T allele (TT + CT) of the TNFAIP3 polymorphism (rs10499194) and the T allele (GT + TT) of STAT4 (rs7574865) independently increased the risk of bDMARD/JAKi inefficiency (TT + CT vs. CC: odds ratio, OR 2.84; 95% confidence interval, CI 1.23–6.56; p=0.013; GT + TT vs. GG: OR 3.18; 95% CI 1.36–7.46; p=0.007). The presence of T minor alleles of TNFSF13B (BAFF) (rs9514828) and G (AG + GG) KCNS1 (rs734784) gene polymorphisms was independently associated with a lower risk of treatment failure (CC vs. CT + TT: OR 0.25; 95% CI 0.10–0.66; p=0.004; AA vs. AG + GG: OR 0.29; 95% CI 0.12–0.74; p=0.008, respectively). For the TNFA gene polymorphism (rs1800629), the multiplicative model was statistically significant (G vs. A: OR 3.12; 95% CI 1.1–9.03; p=0.037), and for the CTLA-4 gene (rs231775), the super-dominant model was statistically significant (AA + GG vs. AG: OR 2.6; 95% CI 1.14–6.25; p=0.022).Conclusion. Six genetic predictors of treatment failure in bDMARDs/JAKi switching were identified: TNFAIP3 (rs10499194), STAT4 (rs7574865), TNFA (rs1800629), TNFSF13B (BAFF) (rs9514828), KCNS1 (rs734784) and CTLA-4 (rs231775).
Body composition and skeletal muscles status in patients with rheumatoid arthritis during treatment with biologic disease-modifying antirheumatic drugs
Authors: Dobrovolskaya O. V. , Kozyreva M. V. , Demin N. V. , Feklistov A. Yu. , Toroptsova N. V. 
Published: February 2025

Objective: to evaluate body composition and functional status of muscle tissue in women with rheumatoid arthritis (RA) in relation to background therapy.Material and methods. The study included 138 patients (mean age 60.8±8.6 years) with confirmed RA. Of these, 18 received tumor necrosis factor-α inhibitors, 30 rituximab, 19 abatacept and 71 methotrexate (MTX) monotherapy. A clinical and laboratory examination, evaluation of body composition using dual-energy X-ray densitometry and tests to assess muscle strength and physical performance were performed.Results and discussion. Muscle and fat mass, bone mineral density and muscle strength did not differ depending on the background therapy. At the same time, gait speed ≤0.8 m/s was less frequent in women receiving biologic disease-modifying antirheumatic drugs (bDMARDs) compared to MT monotherapy (p<0.001). Significant correlations were found between bDMARD therapy and physical performance as assessed by the results of a short physical performance battery (p=0.035) and gait speed (p=0.003). Logistic regression analysis confirmed the association between bDMARD therapy and muscle functional state. Conclusion. No differences in body composition were found depending on the type of background therapy. bDMARD therapy was associated with better skeletal muscle functional state as assessed by gait speed and a short physical performance battery compared to MT monotherapy. Keywords: rheumatoid arthritis; body composition; biologic disease-modifying antirheumatic drugs; physical performance> < 0.001). Significant correlations were found between bDMARD therapy and physical performance as assessed by the results of a short physical performance battery (p=0.035) and gait speed (p=0.003). Logistic regression analysis confirmed the association between bDMARD therapy and muscle functional state.Conclusion. No differences in body composition were found depending on the type of background therapy. bDMARD therapy was associated with better skeletal muscle functional state as assessed by gait speed and a short physical performance battery compared to MT monotherapy.
Efficacy of divozilimab in the treatment of systemic sclerosis: results of the randomized phase III clinical trial BCD-132-5/LIBERIUS
Authors: Ananyeva L. P. , Starovoytova M. N. , Gaydukova I. Z. , Lukina G. V. , Zonova E. V. , Eliseeva L. V. , Fatkhullina G. F. , Abdulganieva D. I. , Krechikova D. G. , Kropotina T. V. , Nesmeyanova O. B. , Vinogradova I. B. , Zhugrova E. S. , Ivanova L. V. , Nikulenkova N. E. , Ziganshin O. R. , Plaksina T. V. , Zlobin M. V. , Grabovetskaya Yu. Yu. , Soroka N. F. , Ershova O. B. , Povarova T. V. , Anoshenkova O. N. , Lutsky A. A. , Zinkina-Orikhan A. V. , Linkova Yu. N. , Fokina E. A. , Porozova A. A. , Eremeeva A. V. 
Published: February 2025

The search for new therapeutic options for the treatment of systemic sclerosis (SSc) is an urgent issue in rheumatology. The article presents the results of the double-blind, randomized, placebo-controlled phase III clinical trial BCD-132-5/LIBERIUS on the efficacy and safety of divozilimab (BCD-132) in the treatment of SSc.Objective: to investigate the efficacy and safety of divozilimab in patients with SSc compared to placebo.Material and methods. After enrolment in the study, patients received divozilimab or placebo for 48 weeks, after which they were switched to an open-label divozilimab therapy until week 96.Results and discussion. Divozilimab was superior to placebo regarding the primary endpoint change in mRSS at week 48 compared to baseline, and the therapy had a positive effect on respiratory function parameters. Divozilimab treatment was well tolerated.Conclusion. Thus, divosilimab may represent a new therapeutic option for patients with SSc.
Psychological characteristics of patients with rheumatoid arthritis with severe anxiety and depression
Authors: Abrosimov I. N. , Yaltonsky V. M. , Lisitsyna T. A. , Abramkin A. A. , Lamcheva E. I , Timashkov A. Yu. , Lila A. M. 
Published: February 2025

The negative impact of chronic disease on the psychological well-being and adaptation of patients with rheumatoid arthritis (RA) remains a common problem despite advances in its comprehensive treatment and rehabilitation. In this context, it is important to investigate the psychological factors that determine the extent of anxiety and depression in patients with RA.Objective: to analyze the perception of the disease, mindfulness and self-compassion as psychological characteristics of patients with RA and marked anxiety-depressive manifestations.Material and methods. A total of 180 patients (149 women and 31 men) with a confirmed diagnosis of RA were examined. Their mean age was 43.41±11.18 years, and the mean duration of the disease was 10.03±8.98 years. A package of psychodiagnostic methods was used to assess the level of anxiety and depression, characteristics of the disease perception, development of mindfulness skills, and components of self-compassion.Results and discussion. Based on the study data, two patient groups were identified: patients with clinically significant anxiety and depressive manifestations and patients without them. The perception of the disease in patients with marked anxiety-depressive manifestations was characterized by the expectation of a threat from the disease, emotional apprehension and a decrease in the sense of personal control over the disease. In addition, in this group general and structural indicators of awareness and self-compassion were reduced.Conclusion. The specificity of disease perception, diminished awareness and capacity for self-compassion can be considered as psychological characteristics of patients with RA who have marked anxiety and depressive manifestations. The study allowed us to gain new, more differentiated ideas about the goals of psychodiagnostics and psychological correction in RA.
Engaging pre-service teachers in an indigenous activity to investigate sustainability and green practices in palm oil production
Authors: Hanson Ruby , Anor Charity E. 
Published: February 2025

Abstract
Indigenous science is fast becoming a pathway to teach the principles of sustainability and green science or green chemistry towards sustainable development, management and conservation of the world’s ecosystems for posterity. This study sought to explore students’ own ideas about sustainability and ‘green’ practices through the indigenous multi-stage production of palm oil. A case study that employed a mixed method approach engaged 86 purposively chosen pre-service teachers. Questionnaires that partly allowed for participants to share their own ideas about palm oil production with respect to sustainability and green practices were used to collect data. Findings from analysed data indicated a positive shift in attitude, knowledge and views towards sustainability and green science practices in their communities as against their entry point.
Coconut oil refinery waste utilization in sustainable development of biodegradable betaine surfactant
Authors: Kedar Rahul P. , Rajput Yogeshsing N. , Girase Chetan D. , Kulkarni Ravindra D. 
Published: February 2025

Abstract
The increasing demand for environmentally friendly surfactants has led to the development of innovative, simplified and solvent-free synthesis methods. This study reports the preparation of 3-dimethylaminopropyl cocoyl betaine, a surfactant, using coconut oil refinery waste as the main raw material. A high yield of 90.46 % was obtained by a three-step esterification process using 3-dimethylaminopropanol and coconut oil deodoriser distillate. Structural analysis of the final product was carried out using NMR and Fourier transformation infrared spectroscopy, together with evaluation of the surfactant properties. The analysis of the surfactant properties of 3-dimethylaminopropyl cocoyl betaine indicated its potential suitability for use in personal care and cosmetic formulations. This study highlights the importance of reusing coconut oil refinery waste to produce environmentally friendly surfactants, supporting the chemical industry’s use of renewable and sustainable resources.
Verletzungen in der Grauzone. Eine rekonstruktive Studie zur Indexikalität sexueller Gewalt
Authors: Kedenburg Olga 
Published: February 2025

Zusammenfassung
Für sexuelle Gewalt ist eine besondere Uneindeutigkeit charakteristisch: Sie zeigt sich in den Erfahrungen (potenziell) Betroffener, in der sozialwissenschaftlichen Auseinandersetzung mit dem Verhältnis von Sexualität und Gewalt und in der gesellschaftspolitischen Debatte um die Grauzone sexueller Gewalt. In diesem Beitrag wird die Uneindeutigkeit sexueller Gewalt als Ausdruck ihrer Indexikalität interpretiert, der sich analytisch mit einer vergleichenden Heuristik von Verletzungserfahrungen und Gewaltdeutungen angenähert wird. Dieses Vorgehen ermöglicht es, der Ambivalenz von Erfahrungen sexueller Verletzungen Raum zu geben, ohne sie zu relativieren: Die indexikale Perspektive erschließt das Leiden an der Uneindeutigkeit als Dimension der Gewaltsamkeit sexueller Gewalt.
Multiple Vulnerabilitäten: Zur Wissenspolitik der Schulschließungen während der COVID-19-Pandemie
Authors: Kaldewey David , Berger Pascal , Weigel Lea , Blome Caitlin , Kuhn Paula , Meck Nicole 
Published: February 2025

Zusammenfassung
Der Beitrag beleuchtet die Debatte um die Schulschließungen während der COVID-19-Pandemie im Horizont einer Theorie multipler Vulnerabilitäten. Untersucht werden Zusammenhänge zwischen epistemisch-normativen Positionierungen und Vulnerabilitätsvorstellungen in einem Sample von 43 qualitativen Interviews mit engagierten Laien, die die Problematik der Schulschließungen auf Twitter diskutiert haben. Es kann gezeigt werden, dass Kinder aus Sicht der Kritiker*innen der Schulschließungen vor allem durch die psychischen und sozialen Folgen gefährdet sind, kaum aber durch die Krankheit selbst. Wer umgekehrt für Schulschließungen, Distanzunterricht oder Infektionsschutzmaßnahmen eintritt, sieht Kinder in erster Linie durch mögliche Infektionen bedroht und schätzt die psychischen und sozialen Folgen weniger problematisch ein. Trotz dieser als Polarisierung lesbaren Differenzen ist allen Interviewten eine Orientierung sowohl am Kindeswohl als auch am wissenschaftlichen Diskurs gemeinsam. Wir interpretieren die Ergebnisse wissens- und wissenschaftssoziologisch und verbinden die Theorie multipler Vulnerabilitäten mit einer Theorie multipler Fakten.
Identifying the preserved network of irrigation canals in the Eridu region, southern Mesopotamia
Authors: Jotheri Jaafar , Rokan Mohammed , Al-Ghanim Ali , Rayne Louise , de Gruchy Michelle , Alabdan Raheem 
Published: February 2025

Abstract
The Eridu region in southern Mesopotamia was occupied from the sixth until the early first millennium BC, and its archaeological landscape remains well preserved. The present study has identified and mapped a vast, intensive, well-developed network of artificial irrigation canals in this region.
Single Bruise Characteristics Associated With Abusive vs Accidental Injury
Authors: Raut Audrey , Pierce Mary Clyde , Kaczor Kim , Lorenz Doug , Bertocci Gina , Bertocci Karen , Simonton Kirsten 
Published: February 2025

OBJECTIVES
The TEN-4-FACESp bruising clinical decision rule (BCDR) is a validated screening tool utilizing information about a child’s body region bruised, age, and pattern of bruising to predict abuse in children younger than 4 years of age. Our objectives were to (1) evaluate the accuracy of the BCDR in predicting abuse when only 1 bruise was present and (2) identify other characteristics differentiating abusive from accidental injury in young children with a single bruise.

METHODS
Patients included in this secondary analysis were those from the BCDR validation study whose only skin finding was a single bruise (including petechiae, subconjunctival hemorrhage, or frenulum injury). Cases were previously classified as abuse, accident, or indeterminate by an expert panel. We compared demographics, clinical characteristics, bruising regions, and psychosocial risk factors (PRFs) between abuse and accident groups.

RESULTS
Of 349 patients with a single bruise, 27 were classified as abuse. The TEN-4-FACESp BCDR performed with 81.5% sensitivity and 87.6% specificity in this sample. Patients with abusive injuries were (1) younger and (2) less likely to present with an injury complaint but more likely to (3) have a bruise in a BCDR-positive region, (4) have a lower Glasgow Coma Score, and (5) have PRFs.

CONCLUSIONS
The TEN-4-FACESp BCDR is an effective screening tool for abuse among young children with a single bruise in the pediatric ED. Even 1 BCDR-positive bruise indicated increased risk for abuse. Negative BCDR results must be interpreted with caution given the higher rate of false negatives in this analysis compared with the validation study.
Metafizyka światła. Wstęp do panteistycznej ekofilozofii Henryka Skolimowskiego
Authors: Fligel Anna 
Published: February 2025

Główną tezą artykułu jest założenie, że metafizyka światła Henryka Skolimowskiego stanowi oryginalną koncepcję metafizyczną, a także że mogła ona powstać tylko pod koniec XX w. i tylko spod pióra osobowości o nastawieniu głęboko interdyscyplinarnym. Skolimowski był niewątpliwym erudytą nie tylko w aspekcie historii filozofii zachodniej, jak i dalekowschodniej, ale też w naukach matematyczno-przyrodniczych. Z wykształcenia był filozofem, a w młodości uzyskał również magisterium z geodezji, co odcisnęło się piętnem w ten sposób, że pogłębiał swoją wiedzę w naukach matematyczno-przyrodniczych do końca swojego życia. Stąd jego umysłowość miała głęboko interdyscyplinarny charakter. Dla pełnego zrozumienia metafizycznej koncepcji światła Skolimowskiego kluczowe jest oderwanie się od tradycyjnych dualizmów metafizycznych, zwłaszcza tych zapoczątkowanych przez platońską tradycję i kontynuowanych przez tradycję judeo-chrześcijańską, których apogeum stanowi filozofia Rene Descartesa.
A new rapid lipoarabinomannan urine assay for tuberculosis: a two-centre diagnostic accuracy evaluation in outpatients with and without HIV
Authors: Hamasur Beston , Okunola Anna O. , Sserubiri James , Dube-Nwamba Welile V. , Abdulgader Shima M. , Ignatowich Lech , Rasool Omid , Nabatanzi Rose , Lorente Sara Puertas , Giraldos David , Joloba Moses , Warren Robin M. , Ssengooba Willy , Theron Grant 
Published: February 2025

Abstract

Introduction: Non-sputum tests for people attending primary care with symptoms of tuberculosis (TB) are a global priority.
Methods: We performed a cross-sectional two-centre diagnostic accuracy study of a next-generation urine lipoarabinomannan assay (Biopromic TB LAM, BP-LAM) and the lateral flow Determine TB LAM Ag assay (LF-LAM) on urine from 629 adults with presumptive pulmonary TB (315 with TB) attending primary care in South Africa and Uganda. An extended sputum microbiological reference standard (eMRS) was used and, in South Africa, sputum induction done.
Results: BP-LAM had higher sensitivity than LF-LAM [95% confidence interval (CI) 63% (58, 69) vs. 22% (18, 27)] and similar specificity [93% (90, 96) vs. 89% (85, 92)]. BP-LAM sensitivity did not differ in HIV-positive vs. -negative people nor by CD4 counts. Specificity was diminished in PLHIV [90% (83, 94) vs. 96% (92, 99)]. The design-locked version of BP-LAM had improved specificity than the prototype [93% (90, 96) vs. 85% (80, 88)]. In people with TB who could not expectorate sputum, 67% (55, 79) were BP-LAM-positive; resulting in similar yield to sputum Xpert MTB/RIF Ultra [64% (49, 78)] in a programmatic scenario where sputum induction is unavailable. BP-LAM false-negatives had, vs. true-positives, less severe disease and were more likely to have previous TB. False-positive results were more likely to be from people who cultured only non-tuberculous mycobacteria [19% (4/21) vs. 4% (12/293) for true-negatives].
Conclusions: BP-LAM has higher sensitivity than LF-LAM, including in HIV-negative people, potentially permitting the expansion of urine LAM testing beyond people with advanced immunosuppression.
Funding: The Global Health Technology Fund (GHIT) programs RFP-TRP-2018-001 and RFP-PD-2020-002, EDCTP2 (RIA2020I-3305, CAGE-TB; TMA2020CDF-3209, RADIANT).
EEG signal analysis for ‘OM’ Mantra Meditation
Authors: Jain Vijaylaxmi , Shiragapur Bahubali , Ranjan Prabhat 
Published: February 2025

Abstract

Spiritual Intelligence through Meditation has recently been integrated into the concept of Multiple Intelligence by Dr. Howard Gardner. To research deeper into Spiritual Intelligence, we have chosen to explore the “OM” Mantra Meditation. This form of meditation has shown the potential to enhance concentration, alleviate stress, reduce anxiety and mitigate depression. During the meditation sessions, we collected the EEG signals from the participants, from which we extracted neural oscillations. We found that variations in beta and gamma frequencies were closely associated with the subject’s meditation experiences. Notably, we observed a positive correlation between the level of beta and gamma activity and the depth of meditation experience among the participants. Furthermore, our observations revealed that experienced meditators exhibited remarkably stable focus with minimal fluctuations compared to non-meditators. This heightened level of focus directly corresponds to their enhanced concentration abilities.
Development and Validation of a Predictive Nomogram for 30-Day Mortality in Sepsis Patients Coexisting with Malignant Tumors ： a Retrospective Cohort Study Using the MIMIC-IV Database
Authors: Qian Lin , Sun Weiting , Ding Peng , Zhang Song , Long Kunlan 
Published: February 2025

Abstract

Background
Sepsis is the main cause of death for cancer patients, and our study aims to evaluate risk factors and develop a model to predict the 30-Day mortality in sepsis patients coexisting with malignant tumors.
Methods
We obtained 4196 sepsis patients coexisting with malignant tumors from the MIMIC-IV database and randomly split them into a training set (2937 patients) and a validation set (1259 patients) at a ratio of 7:3. A multivariable logistic regression model was used to identify independent risk factors for predicting mortality, and the model's performance was evaluated.
Results
Multivariable logistic regression analysis showed that age, gender, CPD, diabetes, AKI, heart rate, APACHE III, cardiovascular system, anion gap, BUN, calcium, creatinine, bilirubin, pH, and PCO2 were independent risk factors. The nomogram achieved optimal performance in discrimination, calibration, and clinical application.
Conclusion
The nomogram effectively predicts the 30-Day mortality in sepsis patients coexisting with malignant tumors, and internal validation confirms its effectiveness. The study results can help clinical doctors make decisions on the treatment of these patients, thus reducing the risk of sepsis and death for cancer patients.
Creating momentum in water operators' partnerships by rapid progress in water production – case studies from two partnerships in Tanzania and Jordan
Authors: Mergel Dorothea , Bochmann Lydia , Czekalla Christoph , Mantel Tomi , Wasala Lawrence , Al-Salhi Ghassan , Haroun Amer , Wendland Claudia 
Published: February 2025

ABSTRACT

This paper presents case studies of Water Operators' Partnerships (WOPs) between MIYAHUNA and HAMBURG WASSER (Jordan and Germany) and KASHWASA (Kahama-Shinyanga Water Supply and Sanitation Authority) and HAMBURG WASSER (Tanzania and Germany) from 2021 to 2024. The case studies demonstrate that technical and economic improvements in the water utilities achieved through the WOPs are closely linked to strong personal relationships and trust between the partners. These elements are crucial for achieving significant and sustainable progress. The paper emphasises the initial focus on optimising water treatment processes within the WOPs. Water production is a core process of most water utilities. Optimised chemical usage in water treatment can lead to immediate benefits, and these quick wins generate savings in daily operation, gaining momentum, building a positive relationship, and enhancing collaboration between the mentor and mentee utilities. This stage is essential for establishing a long-term, sustainable partnership.