bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synoptic conditions and potential causes of the extreme heavy rainfall event of January 2009 over Mindanao Island, Philippines
Authors: Olaguera Lyndon Mark Payanay , Caballar Michelle Español , De Mata Joseph Cabacungan , Dagami Loida Ann Torres , Matsumoto Jun , Kubota Hisayuki 
Published: July 2021

AbstractThis study investigates the synoptic conditions that led to the heavy rainfall/flood (HRF) event in Mindanao Island, Philippines (122 −127°E; 5 −10°N), on January 2009 (JAN2009 HRF) that are less emphasized in previous works. Extensive flooding was reported over Cagayan de Oro City in the northern part of Mindanao, where the rainfall on January 10, 11, and 13, 2009, exceeded the 99th percentile of daily rainfall records of all January of the city from 1979 to 2017 by almost two times. A similar exceedance was also felt in Hinatuan station over the eastern coast of Mindanao Island on January 15, 2009. The interaction of a cold surge shearline over the northern Mindanao Island and the warm tropical easterlies led to enhanced moisture convergence. The warmer air mass is forced to ascend by the advancing colder air mass because it has lower density than the colder air mass. The enhanced moisture convergence and buoyancy difference by the air masses led to enhanced ascent and consequently rainfall along the cold surge shearline. Further analysis shows that enhanced anomalous easterly and northerly winds at 925 hPa are apparent over the Philippines. The anomalous easterly winds sustained the supply of warmer easterlies and collaboratively interacted with the northerly winds that supplied colder temperature air mass.The climatology of this HRF event was examined for all January from 1979 to 2017. The authors identified 15 other cases that are similar to the JAN2009 HRF event and performed lag composite analyses. The results show that the occurrence of these HRF events is facilitated by the southward expansion of the high-pressure system to the north of the Philippines, enhanced cold and warm temperature advections, and enhanced moisture convergence along the cold surge shearline. The results of this study have important implications for disaster mitigation during the northeast monsoon season when rainfall activities are, in general, less intensive over this region.
Evaluation of inter- and intra-operator reliability of manual segmentation of femoral metastatic lesions
Authors: Ataei Ali , Eggermont Florieke , Baars Milan , van der Linden Yvette , de Rooy Jacky , Verdonschot Nico , Tanck Esther 
Published: July 2021

Abstract
Purpose
Accurate identification of metastatic lesions is important for improvement in biomechanical models that calculate the fracture risk of metastatic bones. The aim of this study was therefore to assess the inter- and intra-operator reliability of manual segmentation of femoral metastatic lesions.

Methods
CT scans of 54 metastatic femurs (19 osteolytic, 17 osteoblastic, and 18 mixed) were segmented two times by two operators. Dice coefficients (DCs) were calculated adopting the quantification that a DC˃0.7 indicates good reliability.

Results
Generally, rather poor inter- and intra-operator reliability of lesion segmentation were found. Inter-operator DCs were 0.54 (± 0.28) and 0.50 (± 0.32) for the first and second segmentations, respectively, whereas intra-operator DCs were 0.56 (± 0.28) for operator I and 0.71 (± 0.23) for operator II. Larger lesions scored significantly higher DCs in comparison with smaller lesions. Of the femurs with larger mean segmentation volumes, 83% and 93% were segmented with good inter- and intra-operator DCs (> 0.7), respectively. There was no difference between the mean DCs of osteolytic, osteoblastic, and mixed lesions.

Conclusion
Manual segmentation of femoral bone metastases is very challenging and resulted in unsatisfactory mean reliability values. There is a need for development of a segmentation protocol to reduce the inter- and intra-operator segmentation variation as the first step and use of computer-assisted segmentation tools as a second step as this study shows that manual segmentation of femoral metastatic lesions is highly challenging.
Screening of cultivars for tissue culture response and establishment of genetic transformation in a high-yielding and disease-resistant cultivar of Theobroma cacao
Authors: Jones Jesse , Zhang Elaine , Tucker Dominick , Rietz Daniel , Dahlbeck Douglas , Gomez Michael , Garcia Claudia , Marelli Jean-Philippe , Livingstone Donald , Schnell Ray , Staskawicz Brian , Cho Myeong-Je 
Published: July 2021

AbstractA highly efficient transformation protocol is a prerequisite to developing genetically modified and genome-edited crops. A tissue culture system spanning culture initiation from floral material to conversion of embryos to plants has been tested and improved inTheobroma cacao. Nine cultivars were screened for their tissue culture response and susceptibility toAgrobacteriumtransfer-DNA delivery as measured through transient expression. These key factors were used to determine the genetic transformability of various cultivars. The high-yielding, disease-resistant cultivar INIAPG-038 was selected for stable transformation and the method was further optimized. Multiple transgenic events were produced using two vectors containing both yellow fluorescent protein andneomycin phosphotransferaseII genes. A two-fold strategy to improve both T-DNA delivery and secondary somatic embryogenesis rates was conducted to improve overall transformation frequency. The use ofAgrobacteriumstrain AGL1 and cotyledon tissue derived from secondary somatic embryos ranging in size between 4 to 10 mm resulted in the highest T-DNA delivery efficiency. Furthermore, the use of higher concentrations of basal salts and cupric sulfate in the medium increased the frequency of explants producing greater than ten embryos by five-fold and four-fold during secondary somatic embryogenesis, respectively. Consequently, an optimal combination of all these components resulted in a successful transformation of INIAPG-038 with 3.7% frequency at the T0plant-level. Grafting transgenic scions with undeveloped roots to non-transgenic seedlings with healthy roots helped make plantlets survive and facilitated quick transplantation to the soil. The presented strategy can be applied to improve tissue culture response and transformation frequency in otherTheobroma cacaocultivars.
Digital Hazards for Feeding and Eating: What We Know and What We Don't
Authors: Ioannidis Konstantinos , Chamberlain Samuel R 
Published: July 2021

Abstract
Purpose of Review
We aimed to accrue recent evidence exploring effects of modern online activities (e.g., Internet use) on feeding and eating disorder symptoms, and related traits. We examined available evidence to ascertain any direct influences from online activities on feeding and eating disorders, thereby shedding light on putative mechanisms by which those influences may occur.

Recent Findings
Many facets of problematic usage of the Internet correlate cross sectionally with eating disorder and related psychopathology. There is evidence to suggest that significant effects do exist in the direction of specific Internet activities contributing to eating disorder symptoms, viewed dimensionally. Putative mechanisms are discussed. However, a significant number of eating disorder phenotypes and Internet-related activities remain under-researched.

Summary
Specific facets of engagement with the online environment appear to confer risk for feeding and eating problems, evidence being strongest for non-clinical studies using dimensional measures. More research is required to rigorously confirm causal effects, including in patients meeting formal diagnostic criteria for eating disorders. We also highlight the need for high-quality evidence to explore how eating disorder phenotypes are commonly as well as uniquely affected by different online activities. Such research is needed in order that scientific understanding in this area can be translated to protect those most at risk of disordered eating, including through changes in public health approaches and clinical practice.
Antitumor activity of Koningic acid in thyroid cancer by inhibiting cellular glycolysis
Authors: Jing Changxin , Li Yanyan , Gao Zhifei , Wang Rong 
Published: July 2021

Abstract
Purpose
Koningic acid (KA), a sesquiterpene lactone, has been identified as an antimicrobial agent. Recent studies have revealed KA’s antitumor activities in colorectal cancer, leukemia, and lung cancer. However, its antitumor effect in thyroid cancer remains largely unknown.

Methods
The effects of KA on proliferation, colony formation, apoptosis in thyroid cancer cells were assessed by MTT assay and flow cytometry. After KA treatment, the glycolysis ability of thyroid cancer cells was detected by ECAR, and the glycolytic products and relative ATP levels were measured by ELISA. The underlying mechanisms of antineoplastic activity of KA in thyroid cancer were detected by Western blot. Finally, the antineoplastic activity in vivo was observed in Xenograft mouse models.

Results
KA inhibited the proliferation, colony formation, and increased cell apoptosis in thyroid cancer cell lines in a dose and time-dependent manner. We verified that the glycolysis ability, ATP production, and lactic acid level in thyroid cancer cells had experienced an extensive decrease after KA treatment. In addition, lactic acid, the metabolite of glycolysis, could weaken the effect of KA on its colony formation ability in C643 thyroid cancer cell line. Our data also showed that KA kills thyroid cancer cells by inhibiting the MAPK/ERK pathway and decreasing Bcl-2 level. By contrast with the control group, the growth of xenograft tumor was dramatically inhibited by KA without obvious drug side effects.

Conclusion
Our data demonstrate that KA kills thyroid cancer cell lines by inhibiting their glycolysis ability, the MAPK/ERK pathway and the Bcl-2 level and suggest that KA has potential clinical value in thyroid cancer therapy.
Geometry and symmetry in biochemical reaction systems
Authors: Mulas Raffaella , Sánchez-García Rubén J. , MacArthur Ben D. 
Published: July 2021

AbstractComplex systems of intracellular biochemical reactions have a central role in regulating cell identities and functions. Biochemical reaction systems are typically studied using the language and tools of graph theory. However, graph representations only describe pairwise interactions between molecular species and so are not well suited to modelling complex sets of reactions that may involve numerous reactants and/or products. Here, we make use of a recently developed hypergraph theory of chemical reactions that naturally allows for higher-order interactions to explore the geometry and quantify functional redundancy in biochemical reactions systems. Our results constitute a general theory of automorphisms for oriented hypergraphs and describe the effect of automorphism group structure on hypergraph Laplacian spectra.
A Review of Telemedicine Interventions for Weight Loss
Authors: Ufholz Kelsey , Bhargava Daksh 
Published: July 2021

AbstractPurpose of ReviewTelemedicine has become popular as an alternative for in-person weight loss treatment during the COVID-19 pandemic. This review focuses on weight loss interventions utilizing real-time telemedicine.Recent FindingsTelemedicine interventions are usually run as a weekly counseling and educational session or as a complement to a primarily Web-based intervention. A wide variety of healthcare professionals may provide the intervention. Common content includes portion control, increased physical activity, and relapse prevention. Self-monitoring is associated with intervention success. Modalities considered include online chats, text messages, phone calls, and videoconferences. Videoconferencing may be especially useful in capturing the interpersonal connection associated with in-person care but is understudied compared to other modalities. While many interventions show improvements in weight and weight-related outcomes, small sample sizes limit generalizability. Technology access and digital literacy are both necessary.SummaryTelemedicine interventions can successfully help patients with obesity lose weight. Telemedicine interventions provide a safe, remote alternative and may expand treatment access to hard-to-reach populations. Further research is needed on telemedicine weight loss treatments for seniors, men, and ethnic minorities, as well as on the impact of long-term interventions.
Effects of Experts’ Annotations on Fashion Designers Apprentices’ Gaze Patterns and Verbalisations
Authors: Coppi Alessia Eletta , Oertel Catharine , Cattaneo Alberto 
Published: July 2021

AbstractVisual expertise is a fundamental proficiency in many vocations and many questions have risen on the topic, with studies looking at experts and novices differences’ in observation (e.g., radiologists) or at ways to help novices achieve visual expertise (e.g., through annotations). However, most of these studies focus on white-collar professions and overlook vocational ones. For example, observing is uttermost important for fashion designers who spend most of their professional time on visual tasks related to creating patterns and garments or performing alterations. Therefore, this study focuses on trying to convey a professional way to look at images by exposing apprentices to images annotated (e.g., circles) by experts and identifying if their gaze (e.g., fixation durations and gaze coverage) and verbalisations (i.e., images descriptions) are affected. The study was conducted with 38 apprentices that were exposed to sequential sets of images depicting shirts, first non-annotated (pre-test), then annotated for the experimental group and non-annotated for the control group (training 1 and training 2), and finally non-annotated (post-test). Also, in the pre and post-test and in training 2 apprentices had to verbally describe each image. Gaze was recorded with the Tobii X2–60 tracker. Results for fixation durations showed that the experimental group looked longer in the annotated part of the shirt in training 1 and in the shirt’s central part at post-test. However, the experimental group did not cover a significantly larger area of the shirt compared to control and verbalisations show no difference between the groups at post-test.
Failure assessment for drinking water distribution system in the case of Bahir Dar institute of technology, Ethiopia
Authors: Mesalie Roman Abebe , Aklog Dagnachew , Kifelew Mekash Shiferaw 
Published: July 2021

AbstractIn this paper, the issue of failure assessment in the drinking water distribution system was presented. This specific study was conducted on the water distribution system on the campus of Bahir Dar Institute of Technology. The current problem in Bahir Dar institute of technology is that the water infrastructure is aging and has not been spending adequate to repair, replace, or rehabilitate drinking water distribution systems. This develops higher stresses on the water distribution network causing pipes to crack, or rupture permanently while in service. Due to this problem, the whole water supply components in the distribution network led to increased water loss and quality reduction. The general objective of this study is to assess the risk of the water distribution system in the Bahir Dar Institute of technology water supply distribution system. In this study, a structural risk assessment was developed by using ARC GIS 10.5 and Water Cad V8i to get prioritize maps of the water distribution system and hydraulic analysis of the drinking water distribution system of the institute. In developing this assessment, the score was established based on the preset criteria to evaluate customer point risk and structural point risks such as water quality, water availability, pressure head adequacy, the flow rate of water, pipe, storage facility, and pump. Based on the result obtained from an equal weight approach, the score of the drinking water distribution system risk index is a medium level (2.56) with a low level of structural risk (2.5) and a medium level of consumer point risk (2.62). The results evaluated by the AHP method, structural risk has had the highest weight score (76%) which means it needs more priority than consumption point risk (24%), and the result of drinking water distribution system risk index laid at the medium level (2.7), it indicates the institution drinking water distribution system put at the satisfactory condition with the sum up the effect of medium structural risk index (2.65) and medium consumption point risk (2.82). Based on the findings and conclusions of the study, the components of the campus water supply distribution system, particularly parts of the pipe and the majority of the pump, should be replaced before they become obsolete, and suitable preventive measures should be taken.
The Role of Church Support Networks in the Relationship between Discrimination and Psychiatric Disorders among Older African Americans
Authors: Nguyen Ann W. , Wang Fei , Qin Weidi , Hamler Tyrone C. 
Published: July 2021

Background Few studies have examined the effects of discrimination on mental health specifically among older African Americans despite it being a common experience in this population. Further, knowledge on social resources, such as social relationships, that could mitigate the effects of discrimination is limited in this population. Given the historical and contemporaneous importance of the Black church in African American communities, church members are important support network members and a major source of social support for older African Americans. Purpose To address these knowledge gaps, this study will (1) examine the association between racial discrimination and psychiatric disorders; and (2) determine whether church relationships moderate the impact of racial discrimination on psychiatric disorders. Methods Data from African American respondents aged 55 and older were drawn from the National Survey of American Life ( N = 837). Church relationship variables included receipt of emotional support from, frequency of contact with, and subjective closeness to church members. Regression analyses were used to test the study aims. Results Analyses indicated that more frequent experiences of racial discrimination were associated with meeting criteria for any DSM-IV disorder and a greater number of DSM-IV disorders. Significant interactions revealed that frequency of contact with and subjective closeness to church members mitigated the association between discrimination and meeting criteria for any 12-month disorder and number of 12-month disorders. Conclusions and Implications Altogether, these findings support the literature on the detrimental effects of discrimination on the mental health of older African Americans and provide a more nuanced understanding of the role of church members in the lives of older African Americans. The study findings suggest that church relationships are effective stress coping resources for older African Americans dealing with discrimination. Given the importance and relevance of church members, initial clinical assessments should assess clients’ level of religious involvement and relationships with church members.
Horizon Scanning in Cancer Genomics: How Advances in Genomic Medicine Will Change Cancer Care Over the Next Decade
Authors: Seed Lydia M. 
Published: July 2021

Abstract
Purpose of Review
Advances in genomic medicine have the potential to revolutionise cancer patient care by driving forwards the clinical practice of precision oncology. This review aims to outline how genomic medicine advances may alter the care of cancer patients and their families over the next 10 years.

Recent Findings
The translation of oncogenomic advances into the clinical environment will likely be facilitated by the increasing availability of next-generation sequencing technologies and the increasing genomic literacy of healthcare professionals. The implementation of the centralised, nationwide NHS Genomic Medicine Service promises to improve equity of cancer care and to facilitate personalisation of almost every stage of the care pathway, from informing population screening and how we diagnose cancer to delivering prognoses and surveillance. Advances in cancer pharmacogenomics, and other “omics” technologies, have a tremendous potential to optimise patient care. Genomic medicine advances will also enhance the care offered to cancer patients’ families.

Summary
Genomic medicine advances are likely to transform almost every aspect of a cancer patient’s care pathway. Cancer care will profoundly improve over the next decade, increasing UK cancer survival rates and improving patient outcomes.
Advances in friction stir welding by separate control of shoulder and probe
Authors: Grätzel M. , Sieber F. , Schick-Witte K. J. , Bergmann J. P. 
Published: July 2021

AbstractFriction stir welding (FSW) has developed into a reliable and increasing used industrial joining technology. Various tool configurations can be used for FSW, each of which has advantages and challenges. State-of-the-art FSW employs various tool configurations, including the conventional, the stationary shoulder, and the dual-rotational configuration which is characterized by separate control of shoulder and probe. In this study, an innovative method to combine various tool configurations was developed by a novel FSW spindle stack construction. With an additional servomotor, existing FSW systems can be extended by separate control of shoulder and probe so that varying rotational speeds and rotational directions can be set. This allows enhanced possibilities (a) to adjust frictional heat generation and (b) to apply several tool configurations. The main advantages of this enhanced type of FSW are demonstrated in three ways: increased weld penetration depth, reduction of undesirable machine vibrations, and the combination of varying tool configurations such as stationary shoulder and conventional FSW. The investigations were carried out with 2-mm EN AA 5754 H22 sheets and performed on a robotized FSW setup.
Compact homogeneous Leviflat CR-manifolds
Authors: Al-Abdallah A. R. , Gilligan B. 
Published: July 2021

AbstractWe consider compact Leviflat homogeneous Cauchy–Riemann (CR) manifolds. In this setting, the Levi-foliation exists and we show that all its leaves are homogeneous and biholomorphic. We analyze separately the structure of orbits in complex projective spaces and parallelizable homogeneous CR-manifolds in our context and then combine the projective and parallelizable cases. In codimensions one and two, we also give a classification.
Differences and Similarities of Photocatalysis and Electrocatalysis in Two-Dimensional Nanomaterials: Strategies, Traps, Applications and Challenges
Authors: Qian Weiqi , Xu Suwen , Zhang Xiaoming , Li Chuanbo , Yang Weiyou , Bowen Chris R. , Yang Ya 
Published: July 2021

AbstractPhotocatalysis and electrocatalysis have been essential parts of electrochemical processes for over half a century. Recent progress in the controllable synthesis of 2D nanomaterials has exhibited enhanced catalytic performance compared to bulk materials. This has led to significant interest in the exploitation of 2D nanomaterials for catalysis. There have been a variety of excellent reviews on 2D nanomaterials for catalysis, but related issues of differences and similarities between photocatalysis and electrocatalysis in 2D nanomaterials are still vacant. Here, we provide a comprehensive overview on the differences and similarities of photocatalysis and electrocatalysis in the latest 2D nanomaterials. Strategies and traps for performance enhancement of 2D nanocatalysts are highlighted, which point out the differences and similarities of series issues for photocatalysis and electrocatalysis. In addition, 2D nanocatalysts and their catalytic applications are discussed. Finally, opportunities, challenges and development directions for 2D nanocatalysts are described. The intention of this review is to inspire and direct interest in this research realm for the creation of future 2D nanomaterials for photocatalysis and electrocatalysis.