bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms of Metabolic Adaptation in Wine Yeasts: Role of Gln3 Transcription Factor
Authors: Ferrer-Pinós Aroa , Garrigós Víctor , Matallana Emilia , Aranda Agustín 
Published: September 2021

Wine strains of Saccharomyces cerevisiae have to adapt their metabolism to the changing conditions during their biotechnological use, from the aerobic growth in sucrose-rich molasses for biomass propagation to the anaerobic fermentation of monosaccharides of grape juice during winemaking. Yeast have molecular mechanisms that favor the use of preferred carbon and nitrogen sources to achieve such adaptation. By using specific inhibitors, it was determined that commercial strains offer a wide variety of glucose repression profiles. Transcription factor Gln3 has been involved in glucose and nitrogen repression. Deletion of GLN3 in two commercial wine strains produced different mutant phenotypes and only one of them displayed higher glucose repression and was unable to grow using a respiratory carbon source. Therefore, the role of this transcription factor contributes to the variety of phenotypic behaviors seen in wine strains. This variability is also reflected in the impact of GLN3 deletion in fermentation, although the mutants are always more tolerant to inhibition of the nutrient signaling complex TORC1 by rapamycin, both in laboratory medium and in grape juice fermentation. Therefore, most aspects of nitrogen catabolite repression controlled by TORC1 are conserved in winemaking conditions.
Regulation of Ribosomal Protein Synthesis in Mycobacteria: The Autogenous Control of rpsO
Authors: Aseev Leonid V. , Koledinskaya Ludmila S. , Bychenko Oksana S. , Boni Irina V. 
Published: September 2021

The autogenous regulation of ribosomal protein (r-protein) synthesis plays a key role in maintaining the stoichiometry of ribosomal components in bacteria. In this work, taking the rpsO gene as a classic example, we addressed for the first time the in vivo regulation of r-protein synthesis in the mycobacteria M. smegmatis (Msm) and M. tuberculosis (Mtb). We used a strategy based on chromosomally integrated reporters under the control of the rpsO regulatory regions and the ectopic expression of Msm S15 to measure its impact on the reporter expression. Because the use of E. coli as a host appeared inefficient, a fluorescent reporter system was developed by inserting Msm or Mtb rpsO-egfp fusions into the Msm chromosome and expressing Msm S15 or E. coli S15 in trans from a novel replicative shuttle vector, pAMYC. The results of the eGFP expression measurements in Msm cells provided evidence that the rpsO gene in Msm and Mtb was feedback-regulated at the translation level. The mutagenic analysis showed that the folding of Msm rpsO 5′UTR in a pseudoknot appeared crucial for repression by both Msm S15 and E. coli S15, thus indicating a striking resemblance of the rpsO feedback control in mycobacteria and in E. coli.
Analysis and Forecasting Dynamics of Digital Transformation of Economy of the Russian Federation (on the Example of the Measurement of the Organization’s Digital Performance)
Authors: Prokhorov P. E. , Minashkin V. G. 
Published: September 2021

The introduction of digital technologies in the monitoring and management activities of organizations is an important tool for the transformation of economic system at modern phase of the latest industrial and technological revolution. Currently, there is no unifed methodological apparatus for describing the state and development prospects of digital transformation. The analysis of objective patterns of the digital transformation of the Russian economy can be carried out by constructing mathematical and statistical models that make it possible to analyze the stages of digital maturity in the past and to determine the future development of projected digital phenomena.The purpose of this article lies in modelling and forecasting of dynamics of digital transformation of the activities of organizations.Digital transformation was measured based on indicators of the use of information and communication technologies in organizations, namely: Internet connection, website, purchase of goods and services via the Internet, use of software tools of the ERP, CRM, SCM class.Growth curves are one of the most common tools for modeling technological development trends. For each time series, the accuracy of four models of growth curves was assessed: the Gompertz, Weibull's, logistic and log-logistic.The practical application of this study is that the proposed approach can be used to assess trends in ICT diﬀusion in organizations by type of economic activity and by size to obtain a more complete characterization of digital maturity and further prospects for digital transformation of the Russian economy.
A amplia��o do conceito de liberdade como pressuposto
Authors: Abreu Leonardo 
Published: September 2021

Em que pese o impacto da Filosofia
Iluminista, determinadas teses como a
sujei��o � raz�o, o individualismo e o
Contrato Social, ao estar relacionados com
a ideia da pr�tica da liberdade num per�odo
anterior ao da vida nas coletividades,
acabam por encobrir os mecanismos de
aquisi��o da linguagem, fen�meno central
da experi�ncia humana e do qual emergem
todos os demais fatos: religiosos, pol�ticos,
econ�micos e, sobretudo, jur�dicos, porque
onde houver pessoas em associa��o, haver�
uma normatividade subjacente a regul�-las.
Apesar da exist�ncia de v�rios direitos e de
v�rias liberdades, a Modernidade consagrou
apenas a teoria do monismo estatal, que
s� reconhece como o Direito as leis que
emanam do Estado, e como liberdade,
a prerrogativa de limitar a inger�ncia do
poder p�blico na esfera privada. Prop�e-se
vis�o integrada de conceitos oriundos da
Filosofia, da Antropologia, da Psicologia e
da Sociologia para amplia��o do conceito
usual de liberdade, que tem servido
para legitimar a baixa implementa��o de
direitos humanos em rela��o � parcela
mais empobrecida da popula��o, processo
que compromete sua possibilidade de auto
determina��o.
A toler�ncia e os direitos humanos:
Authors: Leister Margareth 
Published: September 2021

O presente estudo traz uma reflex�o sobre
as diversidades culturais encontradas na
sociedade, dentro de uma perspectiva
que tem como elemento fundamental a
toler�ncia e os Direitos Humanos, onde
o respeito pelo outro e a possibilidade
de compreens�o s�o os �nicos meios que
possibilitam a conviv�ncia harmoniosa
e trazem o reconhecimento de que
a diferen�a est� fundadamentada no
reconhecimento da pluralidade cultural,
podendo-se, desse modo, se vivenciar uma
cultura democr�tica.
JUIZADO ESPECIAL CRIMINAL: UM ESTUDO DE CASO A PARTIR DAS AUDI�NCIAS PRELIMINARES DE CONCILIA��O
Authors: Faisting Andr� Luiz , Oliveira Ricardo Silva de 
Published: September 2021

Este artigo objetiva apresentar parte dos
resultados de uma pesquisa sobre os
Juizados Especiais Criminais que buscou
compreender, entre outras quest�es, as
formas de intera��o entre operadores
do Direito e litigantes nas audi�ncias
preliminares de concilia��o. A participa��o
mais intensa dos usu�rios nessa inst�ncia de
justi�a tem contribu�do para a compreens�o
mais ampla de valores, cren�as e
representa��es sociais da viol�ncia e da
puni��o nesses espa�os menos formais de
resolu��o de conflitos. Uma das conclus�es
da pesquisa foi que, embora os Juizados
tenham ampliado o acesso � justi�a, seus
usu�rios enfrentam, muitas vezes, situa��es
de insatisfa��o com rela��o � forma como
s�o tratados seus conflitos, normalmente
considerados menos relevantes. Al�m
disso, constatou-se a exist�ncia de valores
relativos ao universo simb�lico do cotidiano
para caracterizar comportamentos,
reproduzindo e refor�ando, com isso,
estere�tipos e preconceitos.
El derecho del trabajo contemporaneo proyectado hacia el futuro.
Authors: Palomino Teod�sio A. , Cabanellas Guillermo 
Published: September 2021

Al enfocar la tem�tica relacionada con el ep�grafe, desarrollar� brevemente un conjunto de instituciones vinculadas al Derecho del Trabajo imperante en Iberoam�rica donde es dable apreciar, de modo incisivo, la influencia de la globalizaci�n y el avance
vertiginoso de la ciencia y la tecnolog�a. Los efectos de esta mutaci�n han puesto a nuestros pa�ses bajo un mismo paraguas, oblig�ndonos a la b�squeda de soluciones mancomunadas capaces de extraernos de los predios del subdesarrollo.
Supervision and Control in Euthanasia Law: Going Dutch?
Authors: Adams Maurice , Weyers Heleen 
Published: September 2021

How can one encourage physicians to subject the practice of euthanasia to external supervision and control? This is the task inevitably facing any government that comes to the conclusion that traditional means of protecting life via a strict criminal prohibition of euthanasia do not stop doctors from ending life.
In this article we will deal with how the respective Dutch and Belgian governments dealt with this task: how are the supervision and control systems for euthanasia organised, how do they function, and how are after-the-fact and before-the-fact supervision and control related to each other? The focus will mainly be on the situation in the Netherlands (on which the Belgian situation is modelled), with the Belgian situation presented as contrasting material.
A pris�o de Guant�namo como uma pr�tica desconfirmadora dos direitos fundamentais
Authors: Oliveira Mara Regina de 
Published: September 2021

A inser��o dogm�tica dos direitos fundamentais nos sistemas jur�dicos positivos n�o garante a sua concretiza��o pr�tica e efetiva. Eles sempre correm o risco de serem pervertidos, no seu sentido de verdade, quando s�o confrontados com a permanente instabilidade das decis�es pol�tico-jur�dicas contingentes, que podem ser conflitivas com a sua natureza
estabilizante, humanit�ria e universal. A pris�o de Guant�namo mostra esta pervers�o, desde que analisada sob
o prisma da pragm�tica jur�dica, na medida em que desafia a autoridade das normas protetoras dos direitos fundamentais,
no plano internacional.
Current Challenges of European Integration - 12th Network Europe Conference, 9 – 10 November 2020
Authors: Berne André S. , Ceranic Perisic Jelena , Cibotaru Viorel , de Ruyter Alex , Kunda Ivana , Lock Tobias , McGowan Lee , Müller-Graff Peter Christian , Muravska Tatjana , Vincze Attila 
Published: September 2021

Crises are not a new phenomenon in the context of European integration. Additional integration steps could often only be achieved under the pressure of crises. At present, however, the EU is characterised by multiple crises, so that the integration process as a whole is sometimes being questioned. In 2015, the crisis in the eurozone had escalated to such an extent that for the first time a member state was threatened to leave the eurozone. Furthermore, the massive influx of refugees into the EU has revealed the shortcomings of the Schengen area and the common asylum policy. Finally, with the majority vote of the British in the referendum of 23 June 2016 in favour of the Brexit, the withdrawal of a member state became a reality for the first time. Even in the words of the European Commission, the EU has reached a crossroads. Against this background, the twelfth Network Europe conference included talks on the numerous challenges and future integration scenarios in Europe.
Prime Savings with Prizes in an Islamic Perspective
Authors: Hutagalung Muhammad Wandisyah R , Soemitra Andri , Rasyid Arbanur , Lubis Fitri Yani , Nura Ismail 
Published: September 2021

Prime Savings with Prizes is a savings that uses a mudharabah agreement. The problem in this research was that after the customer opens an account of prime savings with prizes, the customer will get a prize, even though the customer has not managed the savings by the bank. The provisions in syari'ah financial institutions, that the prize is a prize at the end of the period. This study aimed to determine how the implementation of Prime Savings at PT. Bank Muamalat, Padangsidimpuan branch office and to find out the concept of prime savings with prizes seen from an Islamic perspective.
DSN Fatwa No.02/DSN-MUI/IV/2000 concerning savings, that the profit sharing must be stated in the form of a ratio and in the account opening contract. Second, DSN Fatwa No.86/DSN-MUI/XII/2012 concerning prizes in raising funds for syari'ah financial institutions. The research method used was a qualitative method with a descriptive approach. The types of data used were primary data sources and secondary data sources. Data processing techniques. The technique of collecting data were interviews, observation and documentation. Data analysis techniques were data reduction, data editing, data presentation, data conclusion and verification, and data validity techniques. This study found that the concept of giving gifts is a gift given by muamalat bank which is a gift at the beginning of the period, and the concept of gifts is based on interviews from ulama’ and lecturers when viewed from an Islamic perspective that gifts are a voluntary gift from someone to another without expecting a reward so that it is allowed in muamalah without being wronged.
PENGEMBANGAN LIFE SKILL UNTUK KEMANDIRIAN ANAK DI PANTI ASUHAN BUDI UTOMO MUHAMMADIYAH METRO
Authors: Alfarisi Salman , Ari Saputra  
Published: September 2021

Tujuan penelitian: Tujuan penelitian ini adalah untuk mengungkap bagaimana pengembangan life skill untuk kemandirian anak di Panti Asuhan Budi Utomo Muhammadiyah Metro. Metode penelitian, jenis penelitian ini adalah penelitian lapangan (field research), yaitu penelitian dan pengambilan datanya dilakukan di lapangan, dengan menggunakan pendekatan kualitatif dengan metode deskriptif kualitatif . Hasil penelitian, Berdasarkan hasil penelitian, Panti Asuhan Budi Utomo Muhammadiyah Metro telah berusaha melakukan kegiatan-kegiatan yang dapat mengembangkan Life Skill untuk kemandirian Anak-anak asuhnya. Pengembangan life skill untuk kemandirian anak-anak asuh tersebut paling tidak dilakukan dengan cara pengembangan Life Skill untuk Kemandirian Anak Melalui pendidikan baik agama maupun umum, melalui keterampilan komunikasi, melalui tata boga, melaui pertanian, melalui Kesenian, dan melalui peternakan.
MANAGEMENT OF COMMUNITY DEVELOPMENT DA'WAH
Authors: Lubis Zulkarnain 
Published: September 2021

Manajemen Pengembangan Masyarakat adalah suatu upaya memadukan ide-ide beserta gagasan-gagasan baru dengan membentuk pengorganisasian, perencanaan dan memanfaatkan sumber daya yang ada untuk merubah masyarakat ke keadaan yang lebih baik.
Dakwah dalam Islam adalah sebuah upaya untuk mengajak manusia kepada jalan yang benar yang diridhai oleh Allah SWT. Dakwah masa kini tidak cukup dimaknai sebagai aktivitas amar ma’ruf nahi mungkar saja, tetapi lebih jauh dakwah dapat dimaknai sebagai upaya untuk menciptakan memaslahatan hidup manusia sesuai bidang yang digelutinya masing-masing. Dakwah dan perkembangan masyarakat tidak dapat dipisahkan, karena sasaran dakwah dalam Islam adalah manusia tanpa kecuali. Manusia, secara sosiologis cultural selalu mengalami perubahan-perubahan, disinilah dakwah berperan sebagai agen perubahan masyarakat yang selalu menuntun manusia kea rah yang lebih baik.
Masyarakat dalam kehidupan selalu mengalami perubahan dan perubahan itu tidak selalu lebih baik bahkan terjadi sebaliknya. Manusia akan mengalami krisis identitas dirinya sebagai makhluk yang mulia disisi Allah, karena itu dakwah juga mengalami perubahan sesuai dengan transformasi sosial yang berkembang seiring dengan kemajuan ilmu pengetahuan dan teknologi.
Dalam era teknologi saat ini sudah selayaknya masyarakat Islam menunjukkan eksistensinya dimata dunia. Perkembangan masyarakat Islam dituntut dalam segala bidang dan tetap berpegang teguh pada cita-cita dan perjuangan Rasulullah dalam dakwah Islam. Untuk membuktikan perkembangan masyarakat Islam tersebut bukan saja dengan jalan dakwah bil-lisan tetapi lebih ditunjukkan dengan dakwah bil-hal.
GRB 170817A Afterglow from a Relativistic Electron–Positron Pair Wind Observed Off-axis
Authors: Li Long , Dai Zi-Gao 
Published: September 2021

Abstract
A relativistic electron–positron (e
+
e
−) pair wind from a rapidly rotating, strongly magnetized neutron star (NS) would interact with a gamma-ray burst (GRB) external shock and reshape afterglow emission signatures. Assuming that the merger remnant of GW170817 is a long-lived NS, we show that a relativistic e
+
e
− pair wind model with a simple top-hat jet viewed off-axis can reproduce multiwavelength afterglow lightcurves and superluminal motion of GRB 170817A. The Markov Chain Monte Carlo (MCMC) method is adopted to obtain the best-fitting parameters, which give the jet half-opening angle θ

j
≈ 0.12 rad, and the viewing angle θ

v
≈ 0.23 rad. The best-fitting value of θ

v
is close to the lower limit of the prior that is chosen based on the gravitational-wave and electromagnetic observations. In addition, we also derive the initial Lorentz factor Γ0 ≈ 49 and the isotropic kinetic energy E
K,iso ≈ 1× 1052 erg. Consistency between the corrected on-axis values for GRB 170817A and typical values observed for short GRBs indicates that our model can also reproduce the prompt emission of GRB 170817A. An NS with a magnetic field strength B

p
≈ 1.6 × 1013 G is obtained in our fitting, indicating that a relatively low thermalization efficiency η ≲ 10−3 is needed to satisfy observational constraints on the kilonova. Furthermore, our model is able to reproduce a late-time shallow decay in the X-ray lightcurve, and predicts that the X-ray and radio flux will continue to decline in the coming years.
Limitations of the Ca ii 8542 Å Line for the Determination of Magnetic Field Oscillations
Authors: Felipe Tobias , Socas Navarro Hector , Sangeetha C. R. , Milic Ivan 
Published: September 2021

Abstract
Chromospheric umbral oscillations produce periodic brightenings in the core of some spectral lines, known as umbral flashes. They are also accompanied by fluctuations in velocity, temperature, and, according to several recent works, magnetic field. In this study, we aim to ascertain the accuracy of the magnetic field determined from inversions of the Ca ii 8542 Å line. We have developed numerical simulations of wave propagation in a sunspot umbra. Synthetic Stokes profiles emerging from the simulated atmosphere were computed and then inverted using the NICOLE code. The atmospheres inferred from the inversions have been compared with the original parameters from the simulations. Our results show that the inferred chromospheric fluctuations in velocity and temperature match the known oscillations from the numerical simulation. In contrast, the vertical magnetic field obtained from the inversions exhibits an oscillatory pattern with a ∼300 G peak-to-peak amplitude, which is absent in the simulation. We have assessed the error in the inferred parameters by performing numerous inversions with slightly different configurations of the same Stokes profiles. We find that when the atmosphere is approximately at rest, the inversion tends to favor solutions that underestimate the vertical magnetic field strength. On the contrary, during umbral flashes, the values inferred from most of the inversions are concentrated at stronger fields than those from the simulation. Our analysis provides a quantification of the errors associated with the inversions of the Ca ii 8542 Å line and suggests caution with the interpretation of the inferred magnetic field fluctuations.
Formation of Multiple Populations of M5 (NGC 5904)
Authors: Lee Jae-Woo 
Published: September 2021

Abstract
With our new Ca-CN-CH-NH photometry, we revisit the globular cluster (GC) M5. We find that M5 is a mono-metallic GC with a small metallicity dispersion. Our carbon abundances show that the σ[C/Fe] of the M5 CN-s population, with depleted carbon and enhanced nitrogen abundances, is significantly large for a single stellar population. Our new analysis reveals that the M5 CN-s population is well described by the two stellar populations: the CN-sI, being the major CN-s component, with the intermediate carbon and nitrogen abundance and the CN-sE with the most carbon-poor and nitrogen-rich abundance. We find that the CN-sE is significantly more centrally concentrated than the others, while CN-w and CN-sI have similar cumulative radial distributions. The red giant branch bump V magnitude, the helium abundance barometer in mono-metallic populations, of individual populations appears to be correlated with their mean carbon abundance, indicating that carbon abundances are anticorrelated with helium abundances. We propose that the CN-sE formed out of gas that experienced proton-capture processes at high temperatures in the innermost region of the proto-GC of M5 that resided in a dense ambient density environment. Shortly after, the CN-sI formed out of gas diluted from the pristine gas in the more spatially extended region, consistent with the current development of numerical simulations by others.
Les arbres, eux aussi, sont bons à penser
Authors: Bloch Maurice 
Published: September 2021

Comme les animaux, les arbres sont souvent utilisés dans des pratiques rituelles dans différentes parties du monde. Cela nécessite une explication. Si les arbres et les humains sont généralement considérés comme étant, d’une certaine manière, « vivants », cela ne conduit pas toujours à la même classification. Scott Atran affirme que le concept d’être vivant est inné chez tous les humains et que cela ne nécessite pas d’explication supplémentaire. Sur la base de travaux en psychologie, Frank Keil soutient que le concept d’être vivant réunit un certain nombre de théories. Le travail de Susan Carey va plus loin : elle défend l’idée que l’on peut dissocier les différentes théories contenues dans la notion d’être vivant ; ces théories ne sont pas véritablement similaires, et dans chaque cas, une théorie peut être mise en avant plutôt que d’autres. Son travail concerne le développement de la notion de vie ; elle montre comment les enfants construisent cette notion par étapes et avec des attentions différentes, de sorte que les très jeunes enfants et les adultes restent normalement incertains quant à savoir si certaines catégories d’êtres sont vivantes ou non.
Les messagers. Configurations et reconfigurations en taxidermie
Authors: Strivay Lucienne 
Published: September 2021

S’il est une technique systématiquement confrontée aux difficultés et aux miracles de la reconfiguration, c’est la taxidermie. Que fabrique-t-on avec ce qui a été vivant, en l’associant étroitement à des composés chimiques, des métaux, du verre, du bois, etc. ? Comment la collection des spécimens devient-elle un opérateur de reconnexion grâce à l’intervention des artistes dans le muséum d’histoire naturelle ? Quels sont ces nouveaux enjeux alors que les espèces s’éteignent de manière affolante et que les écosystèmes disparaissent sans avoir le temps de s’adapter ? On le voit, les questions soulevées par la taxidermie et ses processus touchent à nos façons de faire monde, à la division des savoirs, au renouvellement des perspectives. Elles nous invitent à une grande reconfiguration dont le refaçonnage des corps devient un prétexte.
Devenir parent à travers les frontières nationales et raciales
Authors: Brun Solène 
Published: September 2021

À partir d’une enquête menée entre 2015 et 2017 sur l’adoption internationale, cet article se penche sur la racialisation du devenir parent, à savoir sur la manière dont le processus d’« emparentement » et de création du lien parental sont mis en tension dans le cas d’une parentalité qui doit opérer à travers les frontières nationales et raciales. L’article met en évidence que le processus d’emparentement occupe différentes scènes (institutionnelle, intime, interactions avec l’entourage), dans lesquelles la question raciale fait irruption. Celle-ci se joue dans une tension protéiforme entre différentes conceptions et gestions de la différence racialisée entre les parents et les enfants. D’une part, un universalisme, compatible avec une vision « colorblind » (aveugle aux « couleurs ») du monde et des rapports sociaux et, d’autre part, une reconnaissance et une prise en compte de la différence racialisée qui prend notamment les traits d’un pragmatisme revendiqué.