bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Asthma and Meniere's Disease: A Nested Case–Control Study
Authors: Kim So Young , Lee Chang Ho , Yoo Dae Myoung , Min Chanyang , Choi Hyo Geun 
Published: October 2021

Objectives/HypothesisThis study aimed to investigate the association between Meniere's disease and prior history of asthma.Study DesignA nested case‐control study.MethodsAmong the patients aged ≥40 years from the Korean National Health Insurance Service‐Health Screening Cohort 2002–2015, 7,734 diagnosed with Meniere's disease between 2004 and 2015 were enrolled in this study. From the 505,834 participants without a prior history of Meniere's disease, 30,936 control participants were selected based on age, sex, income, and region of residence. The presence of a prior history of asthma before the diagnosis of Meniere's disease was compared between the Meniere's disease group and control group using conditional logistic regression with odds ratios (ORs) and 95% confidence intervals (95% CIs).ResultsPrior history of asthma was associated with 1.30 (1.21–1.39) times higher odds of Meniere's disease (E‐value = 1.92 [1.71]). Both allergic asthma and nonallergic asthma patients demonstrated higher odds of Meniere's disease than the control group (adjusted OR = 1.21 [1.08–1.36] and E‐value = 1.72 [1.37] for allergic asthma; adjusted OR = 1.26 [1.17–1.36] and E‐value = 1.83 [1.60] for nonallergic asthma).ConclusionsThis study is the first to demonstrate a positive relationship between Meniere's disease and prior asthma history in adults. The association between prior asthma history and Meniere's disease was noted in both allergic and nonallergic asthma cases. The potential development of Meniere's disease should be considered when managing the asthma patients with dizziness or vertigo.Level of Evidence3 Laryngoscope, 132:864–872, 2022
In situ estimates of kelp forest productivity in macro‐tidal environments
Authors: White Lydia , Loisel Stéphane , Sevin Laure , Davoult Dominique 
Published: October 2021

AbstractAccurately quantifying primary productivity of marine macrophytes is essential to further understanding of coastal ecosystem functioning and will allow its inclusion within marine ecosystem models. Traditional quantification of carbon standing stock and biomass accumulation only allow rough estimates of net primary production whereas incubations that measure photosynthesis in the laboratory lack realism and underestimate true photosynthetic rates. We developed in situ photorespirometry methods to estimate productivity of Laminaria hyperborea, the dominant forest‐building kelp species in Northeast Atlantic. We show that sub‐canopy individuals are better adapted to low light levels with higher photosynthetic efficiency and lower compensation point than larger canopy individuals. Laboratory incubations of L. hyperborea stipes revealed that productivity rates could be positive or negative, even at saturating irradiances, depending on whether they were dominated by autotrophic or heterotrophic communities, respectively. Scaling up productivity estimates based on local population demographics resulted in mean daily net productivity rates of 13.3 and −30.1 g C m−2 d−1, for shallow L. hyperborea forest during late summer and autumn, respectively. At saturating irradiances in the late summer–autumn study period, estimates of net and gross productivity reached 9.4 and 12 g C m−2 h−1, respectively. Sub‐canopy individuals were responsible for 12% of estimated daily productivity during summer, but 20% in autumn. We conclude that in situ photorespirometry provides a more direct measurement of production, unaffected by exudation of dissolved carbon or tissue loss, that can account for sub‐canopy and stipe components of the kelp forest, commonly excluded from traditional studies.
Assessing bioorganic gum performance as a corrosion inhibitor in phosphoric acid medium: Electrochemical and computational analysis
Authors: T. Sathiyapriya , Dhayalan Manikandan , R. Jagadeeswari , Govindasamy Rathika , S. U. Mohammed Riyaz , Ali Khan Moonis , Sillanpää Mika 
Published: October 2021

AbstractThe present investigation was aimed at exploring the anticorrosive behavior of bio‐organic Auraucaria heterophylla gum exudate (AHGE) on mild steel (MS) corrosion in 1 M phosphoric acid solution by weight loss technique, electrochemical studies, and computational analysis. Additionally, the performance was analyzed by morphological and quantum chemical analyses. The weight loss data revealed that AHGE showed 80% of inhibition efficiency at 303 K temperature. Inhibitor adsorption on MS was in line with Langmuir and Tempkin adsorption isotherms. Potentiodynamic studies showed that the investigated AHGE performed as a mixed‐type inhibitor. Electrochemical parameters like charge transfer resistance, double‐layer capacitance, and inhibition efficiency were determined and presented. Results obtained through computational analysis, scanning electron microscopy/energy dispersive X‐ray analysis, and atomic force microscopy studies were well supported by the inhibitive potential of AHGE.
Adhesively bonded CFRP/Al joints: Influence of the surface pretreatment on corrosion during salt spray test
Authors: Schanz Jochen , Nester Sara , Meinhard Dieter , Pott Timo , Riegel Harald , De Silva Anjali K. M. , Harrison David K. , Knoblauch Volker 
Published: October 2021

AbstractThe objective of this study was to investigate the influence of different surface pretreatments on the aging behavior of adhesively bonded carbon fiber reinforced polymers/Al joints in a standardized salt spray environment. Therefore, the bonding surfaces were acetone‐cleaned or laser‐pretreated by near‐infrared laser radiation. The pretreated surfaces were examined using optical microscopes, roughness measurements, and infiltration tests. Mechanical testing of the joints was performed in the unaged state and after five aging durations from 120 to 1440 h. The acetone‐cleaned specimens lose a maximum 20% of their initial average shear strength of 22 MPa after aging up to 1440 h. In contrast, the fracture patterns of the laser‐pretreated samples show corrosive degradation after 720 h, indicating galvanic coupling and crevice corrosion. This leads to a significant decrease in shear strength up to 50% after 1440 h of aging. Therefore, some strategies to avoid contact corrosion via the pretreatment and joining process are presented additionally.
Static and Dynamics of Concentrated Colloidal System Close to the Freezing Transition: Effect of Varying Particle Softness
Authors: Samukcham Jimpaul , Shagolsem Lenin S. 
Published: October 2021

AbstractBy means of dissipative particle dynamics simulations, we study static and dynamic properties of a concentrated colloidal system. In particular, we look at the effect of particle softness on the transition temperature, and on the ordering and dynamics of the system. It is shown that the transition temperature decreases linearly with increasing softness. Also, we study the spatial ordering of particles through radial distribution function and compare among different systems with varying degree of particle softness at the thermodynamic melting temperature. We further investigate the dynamical behaviors of the colloidal system in the vicinity of transition temperature and study the variation of diffusion constant as a function of both temperature and degree of softness. We find that, with increasing particle softness, the particle relaxation time increases and thus the diffusion constant also decreases.
Study on Adsorbent Characteristics of Coconut Coir as a Bio Sorbent for Removal of Methylene Blue Dye
Authors: Malhotra Anu , Lokhande Rama S , Sahu Rajesh , Jain Sushil K. , Sharma K. B. , Tripathi Balram 
Published: October 2021

AbstractAdsorption of a cationic dye, like methylene blue (MB) onto coconut coir dust, is investigated. Coconut coir is a by‐product of coconut industries. Increasing concerns about environment, global warming have led the scientists to focus on the use of agricultural residue and plant waste fibers. Due to the presence of hydroxyl and polar groups in various constituents of cellulosic fibers, the moisture sorption is expected quite high. Objective of this study is to investigate the potential of coconut coir as bio sorbent for the removal of cationic dye (methylene blue). Adsorption is studied as a function of concentration of both adsorbate and adsorbent with pH and temperature.
Pulmonary vascular system: A vulnerable target for COVID‐19
Authors: Ai Jiayuan , Hong Weiqi , Wu Min , Wei Xiawei 
Published: October 2021

AbstractThe number of coronavirus disease 2019 (COVID‐19) cases has been increasing significantly, and the disease has evolved into a global pandemic, posing an unprecedented challenge to the healthcare community. Angiotensin‐converting enzyme 2, the binding and entry receptor of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in hosts, is also expressed on pulmonary vascular endothelium; thus, pulmonary vasculature is a potential target in COVID‐19. Indeed, pulmonary vascular thickening is observed by early clinical imaging, implying a tropism of SARS‐CoV‐2 for pulmonary vasculature. Recent studies reported that COVID‐19 is associated with vascular endothelial damage and dysfunction along with inflammation, coagulopathy, and microthrombosis; all of these pathologic changes are the hallmarks of pulmonary vascular diseases. Notwithstanding the not fully elucidated effects of COVID‐19 on pulmonary vasculature, the vascular endotheliopathy that occurs after infection is attributed to direct infection and indirect damage mainly caused by renin‐angiotensin‐aldosterone system imbalance, coagulation cascade, oxidative stress, immune dysregulation, and intussusceptive angiogenesis. Degradation of endothelial glycocalyx exposes endothelial cell (EC) surface receptors to the vascular lumen, which renders pulmonary ECs more susceptible to SARS‐CoV‐2 infection. The present article reviews the potential pulmonary vascular pathophysiology and clinical presentations in COVID‐19 to provide a basis for clinicians and scientists, providing insights into the development of therapeutic strategies targeting pulmonary vasculature.
Epidemiology of variant transthyretin amyloidosis at a reference center in Argentina
Authors: Saez Maria S. , Aguirre Maria A. , Pérez de Arenaza Diego , Sorroche Patricia , Nucifora Elsa , Posadas Martinez Maria L. 
Published: October 2021

AbstractBackgroundIn Argentina, there is limited data of prevalence of variant transthyretin amyloidosis (ATTRv) and phenotype‐genotype correlation. The laboratory of Hospital Italiano de Buenos Aires (HIBA) is a reference center for transthyretin (TTR) gene sequencing. The Institutional Amyloidosis Registry (RIA) enable us to characterize people with ATTRv. Our aim was to describe the prevalence of TTR mutations at a reference center in Argentina and the phenotypic presentations of patients with ATTRv included in an institutional registry.MethodsRetrospective cohort study of consecutive patients with genetic variants in the TTR gene identified from 2012 to 2019 in the laboratory. We collected all phenotypic characteristics of patients who were clinically evaluated by HIBA doctors.ResultsFive hundred seventy‐six patients tested, 141 positive: p.Val50Met 107, p.Thr80Ala 16, p.Ala117Ser 9, p.Phe84Leu 2, p.Ile127Val 2, p.Tyr134Cys 2, p.Ala56Pro 2, p.Val142Ile 1. Only 20 patients were clinically evaluated. The mean age at diagnosis was 54 years; 70% had family history with a pedigree median of 4. Mutations were p.Thr80Ala 9, p.Val50Met 6, p.Ala56Pro 2, p.Val142Ile 1, p.Phe84Leu 1, and p.Tyr134Cys 1. Eleven patients presented polyneuropathy, 11 had gastrointestinal compromise, six patients had autonomic compromise, six presented cardiac symptoms and four patients presented ocular involvement.ConclusionWe present the first prevalence report of TTR mutations in a reference center of amyloidosis in Argentina. The most frequent genetic variant was p.Val50Met. Our data show considerable phenotypic heterogeneity in the patients with ATTRv.
Deep neural network based CEST and AREX processing: Application in imaging a model of Alzheimer’s disease at 3 T
Authors: Huang Jianpan , Lai Joseph H. C. , Tse Kai‐Hei , Cheng Gerald W. Y. , Liu Yang , Chen Zilin , Han Xiongqi , Chen Lin , Xu Jiadi , Chan Kannie W. Y. 
Published: October 2021

PurposeTo optimize and apply deep neural network based CEST (deepCEST) and apparent exchange dependent‐relaxation (deepAREX) for imaging the mouse brain with Alzheimer's disease (AD) at 3T MRI.MethodsCEST and T1 data of central and anterior brain slices of 10 AD mice and 10 age‐matched wild type (WT) mice were acquired at a 3T animal MRI scanner. The networks of deepCEST/deepAREX were optimized and trained on the WT data. The CEST/AREX contrasts of AD and WT mice predicted by the networks were analyzed and further validated by immunohistochemistry.ResultsAfter optimization and training on CEST data of WT mice, deepCEST/deepAREX could rapidly (~1 s) generate precise CEST and AREX results for unseen CEST data of AD mice, indicating the accuracy and generalization of the networks. Significant lower amide weighted (3.5 ppm) signal related to amyloid β‐peptide (Aβ) plaque depositions, which was validated by immunohistochemistry results, was detected in both central and anterior brain slices of AD mice compared to WT mice. Decreased magnetization transfer (MT) signal was also found in AD mice especially in the anterior slice.ConclusionDeepCEST/deepAREX could rapidly generate accurate CEST/AREX contrasts in animal study. The well‐optimized deepCEST/deepAREX have potential for AD differentiation at 3T MRI.
Group and individual telehealth for chronic musculoskeletal pain: A scoping review
Authors: Wallace L. M. , Falla D. , Rushton A. , Heneghan N. R. 
Published: October 2021

AbstractBackground contextMusculoskeletal (MSK) pain presents a global challenge. Individual and group pain management programmes (PMPs) are recommended approaches for patients with chronic MSK disorders. With advances in remote healthcare capability, telehealth, and the recent COVID‐19 pandemic, the importance of telehealth PMPs has become even more evident. Nevertheless, it is not known how patients perceive PMPs for their MSK complaint when delivered via telehealth.ObjectiveTo synthesise the evidence of patients' experiences of group and individual telehealth PMPs for chronic MSK pain.DesignA scoping review informed by the PRISMA extension for scoping reviews.Data sourcesBased on a planned search strategy, modified following initial searches, an electronic search was conducted of key databases: Cochrane Library, Medline, CINAHL, EMBASE, AMED, SportDiscus and APA PsychInfo from 2010 until 11 May 2021.Study selectionAny qualitative or mixed methods study reporting patient experiences of telehealth PMPs for patients with MSK disorders.Data extraction and data synthesisData were extracted and synthesised using thematic analysis.ResultsFrom 446 identified studies, 10 were included. Just two studies investigated group telehealth PMPs for patients with MSK disorders, with eight delivered individually. Four main themes emerged: (1) Usability of the technology, (2) Tailored care, (3) Therapeutic alliance and (4) Managing behaviour. The findings highlight patient acceptability of telehealth to support self‐management for chronic MSK disorders, with appropriate clinical and technical support. Group telehealth has the potential to empower patients with peer support. Remote delivery of PMPs also impacts on how patients and providers interact, communicate and develop a therapeutic relationship.Conclusions and implicationsBarriers and enablers to engagement in telehealth PMPs for patients with chronic MSK disorders have been identified. Peer support and group cohesiveness can be achieved remotely to enhance the patient experience. There is a critical need for further research in this area.
Spectral deferred correction methods for high‐order accuracy in poroelastic problems
Authors: Yoon Hyun C. , Kim Jihoon 
Published: October 2021

AbstractWe investigate high‐order accuracy in time integration by examining two operator splitting methods for poroelastic problems: the two‐pass and the spectral deferred correction (SDC) methods. To enhance the order of accuracy, the two‐pass method partitions a coupled operator symmetrically, whereas the SDC method corrects truncation errors by establishing an error equation. These high‐order methods are applied to underlying solution strategies, that is, monolithic, fixed‐stress sequential, and undrained sequential methods. We observe that semi‐discretized systems from spatial discretization have forms similar to those of index‐1 differential algebraic equations (DAEs), causing order reduction against the two‐pass method when it is used in conjunction with either the monolithic or sequential method. On the other hand, the SDC in conjunction with the monolithic method exhibits the desired second‐order accuracy in poroelastic problems while increasing the order of accuracy for index‐1 DAEs. However, the SDC in conjunction with either of the two sequential methods does not achieve the desired order of accuracy, and maintains first order because the flow equation for poroelasticity has an additional approximation associated with the volumetric strain rate term, which does not yield exactly the same forms as those of conventional DAEs. Thus, the monolithic SDC method can achieve higher‐order accuracy, but may require higher computational costs because it involves solving matrix systems larger than those for the sequential methods.
Computation of generalized inverses of tensors via t‐product
Authors: Behera Ratikanta , Sahoo Jajati Keshari , Mohapatra Ram N. , Nashed M. Zuhair 
Published: October 2021

AbstractGeneralized inverses of tensors play increasingly important roles in computational mathematics and numerical analysis. It is appropriate to develop the theory of generalized inverses of tensors within the algebraic structure of a ring. In this paper, we study different generalized inverses of tensors over a commutative ring and a noncommutative ring. Several numerical examples are provided in support of the theoretical results. We also propose algorithms for computing the inner inverses, the Moore–Penrose inverse, and weighted Moore–Penrose inverse of tensors over a noncommutative ring. The prowess of some of the results is demonstrated by applying these ideas to solve an image deblurring problem.
Stress constrained topology optimization simultaneously considering the uncertainty of load positions
Authors: Oh Min Kyu , Lee Dok Soo , Yoo Jeonghoon 
Published: October 2021

AbstractThis study presents a topological optimization method simultaneously considering the stress constraint and the uncertainty of the load positions for practical applications. The phase field design method is used to derive the topologically optimal structure shape. The stress penalization function, which makes intermediate design variable values disproportionately expensive, is employed to ensure numerical stability and avoid the singularity during the optimization process. The adaptive mesh refinement and a modified P‐norm stress with correction factor are also employed to reduce the computational cost. As numerical examples, cantilever beam, L‐shaped, and MBB‐beam are presented to verify the proposed design method. The open‐source code FreeFEM++ is used for the finite element analysis and the design process.
A rollercoaster of emotions: An integrative review of emotions and its impact on health professional students' learning in simulation‐based education
Authors: Madsgaard Anine , Smith‐Strøm Hilde , Hunskår Irene , Røykenes Kari 
Published: October 2021

AbstractAimSimulation‐based education establishes a specific learning environment capable of activating emotions before, during and after the task. Research has identified stress and anxiety related to simulation. However, the role of various emotional experiences in a simulation that favour learning is still unclear. This review describes, interprets and synthesizes the current research findings on health professional students' experience of emotions and the effects on student learning in simulations.DesignThis study design was guided by integrative review method.MethodsDatabases were systematically searched for articles. 9,323 records were screened and 16 studies met the inclusion criteria. The study protocol was reported in Prospero.ResultsThree themes emerged from the analysis: (a) simulation as a fearful and stressful situation, (b) variability in emotions experienced during simulation as a rollercoaster of emotions and (c) emotions wide‐ranging effects on students' learning in the simulation.
A second order ensemble method with different subdomain time steps for simulating coupled surface‐groundwater flows
Authors: Jiang Nan , Li Ying , Yang Huanhuan 
Published: October 2021

AbstractIn this article, we propose and study a second order, artificial compressibility ensemble method with different subdomain time steps for the Stokes–Darcy equations, which are the core model for simulating the coupled surface‐groundwater flow ensembles. The algorithm decouples the system into two subphysics problems and allows larger time steps in the porous media region while using smaller time steps in the free flow region. We also adopt an artificial compressibility technique to further decouple the computation of the velocity and the pressure for which the pressure can be updated directly without solving a Poisson equation. The ensemble algorithm results in a common coefficient matrix for all realizations of different samples, consequently allows the use of efficient direct or iterative solvers to reduce the computational cost. We provide comprehensive stability analysis for both the nonensemble and the ensemble algorithms. Our numerical experiments illustrate the algorithm is second‐order convergent and the ensemble scheme reduces the computational time of the nonensemble counterpart by 96%. A realistic numerical experiment on a curvy domain is also presented.
Co‐Crystal Formation of Partially Fluorinated 1,3,5‐Tris(phenylethynyl)benzenes
Authors: Weddeling Jan‐Henrik , Waltersmann Paul Lukas , Neumann Beate , Stammler Hans‐Georg , Mitzel Norbert W. 
Published: October 2021

AbstractSeveral rigid 1,3,5‐tris(phenylethynyl)benzenes with different fluorination patterns were synthesized through selective Sonogashira‐Hagihara coupling reactions to analyze the packing behavior in solid‐state structures. The aggregation is dominated by various intermolecular interactions between aryl substituents, triple bonds, C−H bonds and H⋅⋅⋅F contacts. Co‐crystallization experiments for the analysis of preferred aryl‐aryl‐interactions led to 1 : 1 complexes. Intermolecular phenyl‐perfluorophenyl interactions with short centroid‐centroid distances are dominating these co‐crystal structures. They lead to melting point increases of up to 49 °C for the co‐crystals compared to the pure substances.