bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of Meat and Fish Consumption With Conventional and Radiomics Cardiovascular Magnetic Resonance Phenotypes in the UK Biobank
Authors: Raisi-Estabragh Zahra , McCracken Celeste , Gkontra Polyxeni , Jaggi Akshay , Ardissino Maddalena , Cooper Jackie , Biasiolli Luca , Aung Nay , Piechnik Stefan K. , Neubauer Stefan , Munroe Patricia B. , Lekadir Karim , Harvey Nicholas C. , Petersen Steffen E. 
Published: May 2021

Background: Greater red and processed meat consumption has been linked to adverse cardiovascular outcomes. However, the impact of these exposures on cardiovascular magnetic resonance (CMR) phenotypes has not been adequately studied.Objective: We describe novel associations of meat intake with cardiovascular phenotypes and investigate underlying mechanisms through consideration of a range of covariates.Design: We studied 19,408 UK Biobank participants with CMR data available. Average daily red and processed meat consumption was determined through food frequency questionnaires and expressed as a continuous variable. Oily fish was studied as a comparator, previously associated with favourable cardiac outcomes. We considered associations with conventional CMR indices (ventricular volumes, ejection fraction, stroke volume, left ventricular mass), novel CMR radiomics features (shape, first-order, texture), and arterial compliance measures (arterial stiffness index, aortic distensibility). We used multivariable linear regression to investigate relationships between meat intake and cardiovascular phenotypes, adjusting for confounders (age, sex, deprivation, educational level, smoking, alcohol intake, exercise) and potential covariates on the causal pathway (hypertension, hypercholesterolaemia, diabetes, body mass index).Results: Greater red and processed meat consumption was associated with an unhealthy pattern of biventricular remodelling, worse cardiac function, and poorer arterial compliance. In contrast, greater oily fish consumption was associated with a healthier cardiovascular phenotype and better arterial compliance. There was partial attenuation of associations between red meat and conventional CMR indices with addition of covariates potentially on the causal pathway, indicating a possible mechanistic role for these cardiometabolic morbidities. However, other associations were not altered with inclusion of these covariates, suggesting importance of alternative biological mechanisms underlying these relationships. Radiomics analysis provided deeper phenotyping, demonstrating association of the different dietary habits with distinct ventricular geometry and left ventricular myocardial texture patterns.Conclusions: Greater red and processed meat consumption is associated with impaired cardiovascular health, both in terms of markers of arterial disease and of cardiac structure and function. Cardiometabolic morbidities appeared to have a mechanistic role in the associations of red meat with ventricular phenotypes, but less so for other associations suggesting importance of alternative mechanism for these relationships.
HCK and ABAA: A Newly Designed Pipeline to Improve Fungi Metabarcoding Analysis
Authors: Mlaga Kodjovi D. , Mathieu Alban , Beauparlant Charles Joly , Ott Alban , Khodr Ahmad , Perin Olivier , Droit Arnaud 
Published: May 2021

IntroductionThe fungi ITS sequence length dissimilarity, non-specific amplicons, including chimaera formed during Polymerase Chain Reaction (PCR), added to sequencing errors, create bias during similarity clustering and abundance estimation in the downstream analysis. To overcome these challenges, we present a novel approach, Hierarchical Clustering with Kraken (HCK), to classify ITS1 amplicons and Abundance-Base Alternative Approach (ABAA) pipeline to detect and filter non-specific amplicons in fungi metabarcoding sequencing datasets.Materials and MethodsWe compared the performances of both pipelines against QIIME, KRAKEN, and DADA2 using publicly available fungi ITS mock community datasets and using BLASTn as a reference. We calculated the Precision, Recall, F-score using the True-Positive, False-positive, and False-negative estimation. Alpha diversity (Chao1 and Shannon metrics) was also used to evaluate the diversity estimation of our method.ResultsThe analysis shows that ABAA reduced the number of false-positive with all metabarcoding methods tested, and HCK increases precision and recall. HCK, coupled with ABAA, improves the F-score and bring alpha diversity metric value close to that of the BLASTn alpha diversity values when compared to QIIME, KRAKEN, and DADA2.ConclusionThe developed HCK-ABAA approach allows better identification of the fungi community structures while avoiding use of a reference database for non-specific amplicons filtration. It results in a more robust and stable methodology over time. The software can be downloaded on the following link: https://bitbucket.org/GottySG36/hck/src/master/.
Psychological Burden and Psycho-Oncological Interventions for Patients With Hepatobiliary Cancers–A Systematic Review
Authors: Graf Johanna , Stengel Andreas 
Published: May 2021

BackgroundWorldwide, hepatobiliary cancers are frequent diseases and often accompanied by a poor prognosis. These cancers, with hepatocellular carcinoma (HCC) and cholangiocarcinoma (CHC) being the most frequent, are often associated with a considerable amount of psychological burden such as anxiety, depressiveness, and reduced health-related quality of life (HRQOL) which may lead to psychiatric comorbidities. This systematic review gives an overview on psychological burden and on the effectiveness of psycho-oncological interventions for patients with HCC and CHC.MethodsThe databases PubMed, PubPsych, and PsycINFO were used and searched using the following combination of terms: (Neoplasm OR Cancer OR Tumor OR Carcinoma) AND (Psycho-Oncology OR Psychotherapy OR Psychiatr∗) AND (Liver OR Hepatic OR Hepatocellular OR Gallbladder OR Bile∗). Studies were eligible for inclusion if investigating patients affected with tumors of the liver (HCC/CHC) and using diagnostic instruments to assess mental health symptoms and research concerning specific psycho-oncological interventions. In total, 1027 studies were screened by one author with regard to title and abstracts. Afterward, the two authors of the paper discussed inclusion of possible articles.ResultsTwelve studies focusing on distress, anxiety, and depression symptoms as well as quality of life among patients with HCC/CHC and three studies on psycho-oncological interventions were included. Patients suffering from hepatobiliary cancers often experience considerable psychological burden. A quarter of patients suffer from depressive symptoms; anxiety is even more common among these patients with almost 40%. The HRQOL of those affected is reduced in almost all areas, suicide rates increased and the level of distress is considerably increased in one third of patients even in comparison to those with other kinds of cancer. By psycho-oncological intervention the prevalence of depressive symptoms and anxiety can be reduced, while the quality of life and also the survival rate of patients with hepatobiliary cancer can be increased.Discussion and ConclusionPsychological burden is high in patients with hepatobiliary cancers as reflected in high levels of depressiveness and anxiety as well as reduced quality of life. The use of psycho-oncological interventions can reduce psychological burden and increase quality of life compared to patients receiving standard support only.Systematic Review Registration(prospero), identifier (CRD42021243192).
Risk Factors for Clonorchis sinensis Infection in Residents of Binyang, Guangxi: A Cross-Sectional and Logistic Analysis Study
Authors: Xu Meng , Jiang Yanyan , Yin Jianhai , Cao Shengkui , Shen Yujuan , Cao Jianping 
Published: May 2021

Background: Clonorchiasis is a serious food-borne parasitic disease caused by Clonorchis sinensis infection. C. sinensis, a major fish-borne trematode, is a known causative agent of cholangiocarcinoma. The risk factors for C. sinensis infection include individual eating behaviors and environmental factors. In this study, we evaluated the C. sinensis infection rate and the associated risk factors among residents in Binyang County, Guangxi, China.Methods: In 2016 and 2017, five villages from Binyang, Guangxi were selected by multistage cluster random sampling for a cross-sectional study. A modified Kato-Katz thick smear method was used to examine C. sinensis eggs in fecal samples in triplicate (three smears for each sample). Both uni-variate and multi-variate logistic regression analyses were carried out to identify the risk factors for C. sinensis infection.Results: A total of 1,977 fecal samples were collected from villagers in the investigated areas. The overall infection rates of C. sinensis in Binyang County was 20.49% (405/1,977). The mean age of participants was 39.42 ± 23.48 (range: 3–89 years old), and the highest infection rate (33.72%) was seen in the age group of 40-49 years old, followed by those aged 50–59 (31.83%). Multi-variate logistic regression analysis showed that higher infection rates were significantly associated with males (aOR = 6.51, 95% CI = 4.67–9.08), Zhuang (aOR = 2.41, 95% CI = 1.62–3.59), ages (aOR = 33.51, 95% CI = 10.13–110.86), frequency of raw fresh fish consumption (aOR = 14.56, 95% CI = 9.80–21.63), and close contact with cats and dogs (aOR = 1.53, 95% CI = 1.02–2.30). Occupations and education levels showed no significant association with C. sinensis infection (P &gt; 0.05).Conclusions: High levels of C. sinensis infection were observed among residents in Binyang County, Guangxi. Intervention strategies should be strengthened among the investigated population at high risk, such as males, Zhuang and older individuals, especially those who frequently eat raw fresh fish. In addition, the individuals contacting with cats and/or dogs were observed to have significantly higher infection rate of C. sinensis than those having no contact with cats and dogs. The association between contacting with cats and/or dogs and C. sinensis infection needs to be explored and confirmed in the future study by more epidemiological investigations of human C. sinensis infection from different areas.
СУЧАСНИЙ СТАН ТА ПРОБЛЕМИ “ЦИФРОВІЗАЦІЇ” В УКРАЇНІ
Authors: Dovbysh A.S.  , Kotukh Ye.V.  
Published: May 2021

У статті досліджено особливості цифровізації в публічному управлінні, сформульовано основні напрями забезпечення кібербезпеки при цьому. З урахуванням комплексного науково-методологічного аналізу висвітлені окремі особливості організації комунікації суб’єктів публічного управління залежно від рівня та розміру організації. Проаналізовано сучасний стан кібербезпеки, а також визначено шляхи підвищення її рівня в сфері публічно го управління та в цілому в Україні. Пріоритетним шляхами підвищення рівня кібербезпеки в публічному секторі в сучасних умовах має стати збільшення бюджетного фінансування відповідної сфери, стратегічне інвестування в кібераналітику і хмарні технології, створення в організаціях спеціальних підрозділів з кіберзахисту, установка сучасного програмного забезпечення та його постійне оновлення, регулярне підвищення кваліфікації всіх працівників з питань захисту організаційної та персональної інформації.
REŞİT OLMAYANLA CİNSEL İLİŞKİ SUÇUNDA FAİL (TCK m.104)
Authors: SARIGÜL Ali  Tanju 
Published: May 2021

Türk Ceza Kanunu’nda cinsel dokunulmazlığa karşı suçlarda öğretide üzerinde en çok tartışılan suç “reşit olmayanla cinsel ilişki” suçu olmuştur. Özellikle rızaya dayalı cinsel ilişkinin her iki tarafının da reşit olmaması ya da on sekiz yaşın altında olması durumunda ceza hukukunun müdahale alanı dışında kalması gerektiği konusunda öğretide görüş birliği bulunmaktadır. Ancak hukuk uygulamamızda on beş yaşın üzerindeki akran çocuklar arasında gerçekleşen rızaya dayalı cinsel ilişkilerin suç olarak kabul edildiği, herhangi başka bir değerlendirme bile yapılmasına ihtiyaç duyulmaksızın erkek çocuğun fail, kız çocuğun ise mağdur olarak belirlendiği görülmektedir. Korunan hukuki yararla uyuşmadığını değerlendirdiğimiz ve bir gerekçeye dayanmayan bu kararlar, uygulamada tutarsız sonuçlara ve mağduriyetlere neden olmaktadır.
Kanaatimizce sorunun çözümü; kanun hükmünün Avrupa Konseyi Çocukların Cinsel Sömürü ve İstismara Karşı Korunması Sözleşmesi kapsamında yapılabilecek bir yorumuyla mümkün olabilecektir. Söz konusu Sözleşmede bir çocukla cinsel faaliyette bulunmanın yasak olduğu yaş alt sınırının taraf devletlerce belirlenmesi gerektiği hüküm altına alınmıştır (m.18). Sözleşme kapsamında dikkat edilmesi gereken diğer husus ise çocuklar arasındaki rızaya dayalı cinsel faaliyetlerin bu kapsamda değerlendirilmemesi gerektiğidir. Dolayısıyla çocuklar arasındaki rızaya dayalı cinsel ilişki, ceza hukukunun dışında tutulmalı, suçun faili olabilmek için on sekiz yaşın tamamlanmış olması koşulu aranmalıdır.
CAN THE POLICE USE WEAPONS IN CASES OTHER THAN LEGITIMATE DEFENCE? A COMPARATIVE STUDY WITH THE FRENCH EXAMPLE
Authors: ÇETİNKAYA M. Buhari 
Published: May 2021

Law enforcement forces are authorized to the use of weapons in accordance with their duties. The use of the body-targeted weapons conflicts with the right to life and body integrity. The limits of this authority, which conflicts with the most valuable rights, should be determined very well. Law enforcement forces should exercise this authority within the framework of criteria and instructions that leave no room for doubt. Events that took place in Turkey, in 2014, the terrorist attacks that took place in France, in 2015 and 2016 have led to the re-opening of discussion on these authorities.
Law enforcement forces is equipped with the authority to the use of weapons within the framework of their duty to maintain public order. This authority is related to the authorization of the law. Additionally, in connection with its public duty, they are obliged to prevent attacks that will take place within the context of preventive activities it carries out. This is also related to the legitimate defence. The authorization of the law implies a broader concept than legitimate defence. The French legislator, considering that the powers of the national police are insufficient in the face of the attacks that took place in recent years, evaluated the authority to the use of weapons in a different framework. Evaluating the perspective of the actuality condition of the legitimate defence broader, can lead to a broader concept than the legitimate defence. It can be also concluded that the concept of legitimate defence has not been abandoned due to the fact that the necessity and proportionality conditions of legitimate defence has become much stricter.
In this study, we will examine how the new French framework law related to the use of weapons establishes a legitimate defence concept specific to the law enforcement forces. In this direction, we will consider the situation in Turkish law.
Persepsi Pemilih Pemula Terhadap Kampanye Politik Perempuan Melalui Instagram (Studi Deskriptif : Persepsi Mahasiswa Prodi Ilmu Komunikasi UNJ Terhadap Kampanye Politik Krisdayanti Melalui Instagram)
Authors: Rosdiani Khairunnisa , Putri K. Y.S. 
Published: May 2021

Instagram digunakan oleh para calon legislatif untuk menjadi sarana berkampanye guna menumbuhkan citra positif serta menarik suara dari para pengguna instagram. Kecerdasan memilih untuk para pemilih pemula juga dilihat dari kepopuleran calon legislatif, serta luasnya jangkauan media sosial dapat membuat semakin tinggi dukungan untuk para calon legislatif. Metode penelitian menggunakan kuantitatif deskriptif dengan teknik yang digunakan yaitu dalam pengumpulan data dalan bentuk kuesioner. Pemilih pemula di prodi Ilmu Komunikasi UNJ menjadi sample dengan jumlah 55 orang dari total 120 mahasiswa ilmu komunikasi UNJ. Hasil penelitian menunjukkan bahwa pemilih pemula di prodi ilmu komunikasi unj dalam persepsi pemilih pemula dengan aspek memilih, mengatur serta menginterprestasikan ternyata masih kurang dalam studi kasus kampanye krisdayanti di instagram maupun calon legislative lainnya.
INTERNALISASI NILAI-NILAI TASAWUF DI PONDOK PESANTREN AL-AMIEN PRENDUAN
Authors: Sutrisno Andri 
Published: May 2021

Ilmu tasawuf merupakan suatu ilmu yang mengutamakan diri manusia agar memiliki kebersihan ruhani dan jiwa. Di Pondok Pesantren al-Amien Prenduan menanamkan nilai-nilai yang ada dalam ilmu tasawuf. Hal ini bertujuan agar para santri selalu taat pada perintah Allah Swt. dan memiliki nilai-nilai persatuan antar-sesama santri. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan jenis penelitian lapangan. Adapun metode pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Data tersebut kemudian dianalisis dengan reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan, pertama, proses internalisasi nilai-nilai tasawuf melalui nilai Ilahi dan nilai insani di Pondok Pesantren al-Amien Prenduan; kedua, bahwa faktor pendukung dalam internalisasi nilai tasawuf melalui upaya pendampingan pendidikan selama 24 jam dan suri tauladan yang baik oleh para kiai dan para guru. Sedangkan faktor penghambat internalisasi tersebut antara lain para santri masih banyak yang melanggar disiplin pondok dan karena latar belakang keberagaman suku yang berbeda-beda baik dari Jawa, luar Jawa atau bahkan dari luar Indonesia.Sufism is a science that prioritizes human beings in order to have the cleanliness of the soul and spirit. The boarding school of al-Amien Prenduan instilled the values that exist in the science of Sufism. The goal is for the students to always obey the command of Allah Almighty and have the values of unity among fellow students. This study uses a descriptive qualitative approach to the type of field research. The data collection method uses observation, interview and documentation. Then the data is analyzed with data reduction, data presentation and conclusion withdrawal. The results of this study show that: 1) the process of internalization of the Sufism values in boarding schools through divine values and human values; 2) supporting factors in internalizing the value of Sufism with the assistance and education for 24 hours and good suri tauladan from the kiai and teachers. While the inhibitory factor is among the students are still many who violate the discipline of the cottage and because of the background of the diversity of different tribes both from Java, outside Java or even outside Indonesia.
Peran penyuluh peternakan dalam peningkatan pendapatan anggota kelompok peternak babi di Kecamatan Tompaso Barat Kabupaten Minahasa
Authors: Kogoya Y , Lenzun G D , Wantasen E 
Published: May 2021

THE ROLE OF ANIMAL HUSBANDRY EXTENSION IN INCREASING INCOME OF PIG FARMER GROUP IN WEST TOMPASO DISTRICT, MINAHASA REGENCY.This study aims to see how the responses of farmers to the role ofextension workers in increasing the income of pig farming in Kamanga Village, West Tompaso District, Minahasa Regency. The data sources are primary and secondary. Observation and interview data collection methods. The population of breeders who raise pigs and the number of samples taken are members of the Kamanga Village hog farming group who have received guidance from the Minahasa District Agriculture, Animal Husbandry and Plantation Agency. Result study showed that extension officer from the agricultur and livestock service have a major role in increasing of income of pigs breeders in Kamanga village , Tompaso Sub District
Pengaruh penyuluhan terhadap pendapatan peternak babi di desa Kiawa dua Timur Kecamatan Kawangkoan Utara
Authors: Hutabarat S J , Sajow A A , Lombogia S O. B , Warouw Z M 
Published: May 2021

THE EXTENSION EFFECT ON THE INCOME OF PIG FARMERS IN KIAWA DUA TIMUR VILLAGE, KAWANGKOAN UTARA SUB-DISTRICT. The research was conducted in Kiawa Dua Timur village, Kawangkoan district, Minahasa district for one month from June to July 2020. This study aims to determine the effect of counseling on increasing the income of pig farmer groups in Minahasa Regency by taking the case in Kiawa Dua Timur village, Kawangkoan Utara district. This research applies survey research in the form of descriptive tabular. Descriptive analysis is used to explain general things then tabular is used to explain the relationship between variables in tabular form. The survey was conducted by interview method with a questionnaire guide. Interviews were conducted using structured interview methods and questionnaire data collection methods which were distributed to thirty respondents of farmers. The results of study showed that extension services have a very big influence on increasing the income of the members of the pig farmers in the village of Kiawa Dua Timur. The income of farmers before counseling was Rp. 5.833 / month. Meanwhile, the farmer's income after the counseling was Rp.880.333/ month. The pig farming business carried out by the farmer group in Kiawa Dua Timur Village, North Kawangkoan District is economically profitable and feasible to develop.
Peran penyuluh dalam meningkatkan adopsi inovasi teknologi pakan ternak sapi di Kecamatan Totikum Kabupaten Banggai Kepulauan
Authors: Radjab A I. Z , Lainawa J , Lenzun G D 
Published: May 2021

THE ROLE OF COUNSELING IN INSCREASING ADOPTION INOVATION OF FEED TECHNOLOGY ON BEEF CATTLE IN DISTRICT OF TOTIKUM BANGGAI ISLANDS. The aim of this study was to determine the role of guidance in introducing innovations in the use of feed technology in increasing the cattle population.The respondents in this qualitative study were determined by means of "targeted sampling", with 22 breeders being selected as respondents, based on the criteria of having more than 3 cattle with experience over 3 years. The results showed that the advice given to respondents did not relate to specific feed technology material, although farmers really need this knowledge for the development of livestock businesses. In addition, the perception of farmers is that due to their formal educational background, the existing cultivation workers fall under the competence of animal husbandry experts and were not in the animal husbandry field. In general, cattle farming in Totikum Subdistrict, Banggai Islands Regency was still aimed at meeting family food needs, not for commercial purposes, but when in an emergency situation farmers sell cattle through intermediaries in the village at a price that was not affordable for farmers. Therefore, it was concluded that the expansion activities carried out in Totikum District, Banggai Islands Regency played no role in the introduction of innovations in cattle feed technology.