bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric analysis of bronchopulmonary dysplasia in extremely premature infants in the Web of Science database using CiteSpace software
Authors: Zhou Qin , Kong Haibo , He Baomei , Zhou Suya 
Published: April 2021

Abstract
Objectives: To review the literature related to bronchopulmonary dysplasia in extremely premature infants, summarize research hotspots, and report trends. Methods: Relevant articles from 2008 to 2020 were retrieved from the Web of Science Core Collection database, and we extracted the following data: title, abstract, year, keywords, author, organization, journal and cited literature. We downloaded the data into CiteSpace (version 5.7.R3) to summarize countries, institutions, journals, and authors. We visualized the data with a knowledge map, collaborative network analysis, cluster analysis, and burst keyword analysis.Results: We identified 610 articles on bronchopulmonary dysplasia in extremely premature infants. The United States had the most articles on this topic (302 articles), followed by Canada (49 articles) and Germany (44 articles). The top three institutions, high-yield journals, and authors were all from the United States. The most common keywords were neurodevelopmental disorders, active perinatal care, mechanical ventilation, inflammation, pulmonary hypertension, low-dose hydrocortisone, development, and patent ductus arteriosus.Conclusions: This study illustrates the trends and frontiers in the study of bronchopulmonary dysplasia in extremely premature infants. The current hot issues are to identify the high-risk factors of bronchopulmonary dysplasia in extremely premature infants, reasonable hormone use, new cell therapy, and management of complications.
Clinical expression and prognosis of SUV39H1 in diffuse large B-cell lymphoma
Authors: Zhang Yue , Wen Qing , Lei Ya-Xin , Ge Jing-Jing , Kong Xiao-Shuang , Wang Wen-Hua , Wang Ze-Yuan , Hou Hu-Ting , Qian Si-Yu , Wu Shao-Xuan , Wang Guan-Nan , Li Wen-Cai , Zhang Ming-Zhi , Zhang Xu-Dong , Chen Qing-Jiang 
Published: April 2021

Abstract
Background: Epigenetic regulation plays vital roles in the oncogenesis and treatment of diffuse large B-cell lymphoma (DLBCL). The H3K9me3-specific histone methyltransferase SUV39H1 is an epigenetic gene that promotes the progression of a variety of malignancies. However, the roles of SUV39H1 in DLBCL remain unclear.Methods: Initially, the Oncomine, Cancer Cell Line Encyclopedia (CCLE), UALCAN and Gene Expression Profiling Interactive Analysis (GEPIA) databases were searched to explore the expression of SUV39H1 in DLBCL. The clinical parameters and pathological sections of 61 successive patients, including 47 cases of DLBCL and 14 cases of reactive lymphoid hyperplasia, were collected from January 2019 to November 2020. Immunohistochemistry was conducted to verify the results of the database search. Finally, relevant parameters and pathological results were combined to analyze the expression of SUV39H1.Results: We found that the expression of SUV39H1 in DLBCL tissues was higher than that in normal and other cancer tissues (P<0.05) in database and immunohistochemistry analyses. Among the analyzed clinical parameters, only tumor size was closely associated with SUV39H1 (P=0.037), suggesting that patients with high SUV39H1 expression are less likely to develop tumors over 7.5 cm in size. Regarding survival, the group with high SUV39H1 expression had a lower survival rate than the group with low SUV39H1 expression in terms of 10-year disease-free survival (DFS) according to the database analyses (P=0.035). However, SUV39H1 was revealed as an independent predictor of overall survival (OS) and progression-free survival (PFS) in patients from both databases and our hospital (P>0.05).Conclusion: SUV39H1 expression is higher in DLBCL tissues than in normal and other cancer tissues, indicating that DLBCL patients may not develop bulky tumors over follow-up and suggesting that SUV39H1 might serve not only as a predictive factor in the clinic but also as a target for the epigenetic therapy of DLBCL.
Virulence Characteristics and Molecular Epidemiology of Pyogenic Liver Abscess Causing Multidrug Resistant Klebsiella pneumoniae in Wenzhou, China
Authors: Wang Zhongyong , Zhang Siqin , Huang Na , Liu Shixing , Xu Ye , Zhao Yajie , Cao Jianming , Zhou Tieli 
Published: April 2021

Abstract
Background

To date, little is known about the virulence characteristics of pyogenic liver abscess (PLA) that cause multidrug resistant (MDR) Klebsiella pneumoniae (K. pneumoniae), which might be due to the rarity of these strains. This study aimed to analyze the virulence characteristics and molecular epidemiology of 12 MDR strains obtained from 163 PLA cases in a tertiary teaching hospital from the perspective of clinical characteristics, virulence phenotypes, and genotypes.
Methods

The MDR strains were obtained from sterile fluid samples collected from patients with PLA. The antimicrobial susceptibility testing was confirmed by the agar dilution method and microdilution broth method. The virulence phenotypes were analyzed by the growth curves, string test, capsular quantification, serum killing test, biofilm formation assay and infection model. Polymerase chain reaction (PCR) was used to investigate the virulence genotypes. The molecular epidemiology was identified by multilocus sequence typing (MLST).
Results

The results of growth curves, string test, capsular quantification, serum killing test, biofilm formation assay, and infection model revealed that the virulence phenotypes of the 12 PLA-causing MDR K. pneumoniae were similar to or more obvious than those of the typical hypervirulent K. pneumoniae strains. These MDR strains were mainly non-K1/K2 serotypes and carried multiple virulence genes. The results of MLST illustrated that the MDR strains were categorized into 9 sequence types.
Conclusions

This is the first study to analyze the virulence characteristics in PLA-causing MDR strains. The data revealed the coexistence of hypervirulence and MDR in PLA-causing MDR K. pneumoniae strains, and the clones of these strains were diverse and scattered. Also, one ST11 carbapenem-resistant hypervirulent strain was identified in PLA.
High detection rate and risk factors of melanosis coli in end-stage renal disease patients awaiting kidney transplantation: a single-center retrospective study in China
Authors: Wang Yang , Huang Wei , Li Yang , Zhang Wuxing 
Published: April 2021

Abstract
BackgroundRhubarb-containing Traditional Chinese Medicine (TCM) is widely used to manage renal failure in China. Studies show that anthranoids contained in rhubarb are related to the occurrence of melanosis coli (MC). However, no study on the rate of MC in end-stage renal disease (ESRD) patients has been reported.MethodsWe conducted a retrospective study on 99 ESRD patients who received a colonoscopy as part of pre-transplant work-up between Jan 1, 2017 and July 1, 2020 in a single center in Beijing, China. 200 age- and gender-matched subjects with normal renal function and received a colonoscopy for health screening in the same period were randomly selected as control group. Univariate analysis and multivariate logistic regression were performed in succession to determine the association between ESRD and MC, and also probe the independent MC risk factors in ESRD patients.ResultsAmong the 99 ESRD patients, MC was detected in 19, with a detection rate of 19.2% (95% confidence interval [CI]: 11.3%, 27.1%). In contrast, among 200 control subjects, MC was only detected in 1 subject, with an detection rate of 0.5% (95%CI: 0.5%, 1.5%) (ESRD vs. control: odds ratio [OR] = 47.263, 95% CI: 6.222, 358.981; p=0.000). After adjustment of age, body mass index(BMI), albumin, hemoglobin and Charlson comorbidity index, being ESRD was still associated with the presence of MC (OR = 36.251, 95%CI: 3.435, 382.559, p = 0.003). In ESRD patients, both univariate analysis (OR = 4.358, 95% CI: 1.329, 14.286; p = 0.012) and multivariate logistic regression (OR = 4.916, 95% CI: 1.462, 16.525, p = 0.010) found that past use of Rhubarb-containing TCM was the only independent risk factor of MC. However, when the ESRD patients with above use history were excluded, MC rate in ESRD was still higher than non-ESRD group (8.5% vs. 0.5%; OR = 18.512, 95% CI: 2.019, 169.755; p = 0.000).ConclusionOur work highlights that MC rate is high and rhubarb-containing TCM use might be a risk factor in Chinese ESRD patients. There is a need for arranging high quality studies to examine the development of MC in ESRD, especially those awaiting transplantation.
Social responsibility as the dominant driver of the evolution of reporting from financial to non-financial: theory and methodology
Authors: Bychkova Svetlana , Karelskaia Svetlana , Abdalova Elena , Zhidkova Elena 
Published: April 2021

Introduction. For over half a century, corporate social responsibility has been in the center of scientific discourse. Its basic concept has become part of strategic management, changing the content of financial reporting and leading to new forms of corporate reporting.
Study objects and methods. The article substantiated the importance of studying corporate social responsibility (CSR) concepts and national models. The study covered the CSR basic concept, targets and paradigms. The evolution of CSR was considered in terms of its impact on the formation of non-financial reporting.
Results and discussion. The authors identified two stages of non-financial reporting development and two directions for the convergence of financial and non-financial reporting. They proposed an assessment matrix to measure facts, actions, and resources in the past, present, and future. This matrix can help companies to generate information for integrated reporting by showing the impact of each type of capital (financial, production, human, intellectual, social, and environmental) on their value creation. Within a promising direction for developing non-financial reporting in conjunction with financial reporting, the authors set requirements to reflect the impact of climate risks on the company’s activities in accordance with the recommendations of the Task Force on Climate-Related Financial Disclosures. The authors discussed both standardized and their own approaches to CSR indicators. Finally, they addressed the problem of reliability of non-financial reporting, discussed various forms of its verification (taking evidence from food industry enterprises), and set specific principles to control non-financial reporting indicators.
Conclusion. The authors identified further promising areas of research in the theory and practice of CSR. Their findings can be used in scientific debates on CSR and in the practice of corporate reporting.
Egyptian kishk as a fortificant: Impact on the quality of biscuit
Authors: Ibrahim Gamil , Bahgaat Wafaa , Hussein Ahmed 
Published: April 2021

Introduction. Biscuit is a mass-consumption product worldwide. As biscuit contains low amount of protein, it can be fortified with protein-containing raw materials. In the present work, we fortified biscuit with kishk, an Egyptian dairy product, and evaluated changes in its physicochemical properties and volatile compounds.
Study objects and methods. We analyzed biscuit from wheat flour (control sample) and biscuit form wheat flour with 10, 20, 30, 40, and 50% of kishk (experimental samples). The experiments were carried out by using standard methods.
Results and discussion. The fortified biscuit samples showed higher lightness (L*) values than control. The antioxidant activity in the biscuit increased with the increasing amount of kishk. Aldehydes were the main volatile compounds in all the biscuit samples, followed by sulfur-containing compounds and alcohols. The predominant aldehyde was benzldehyde. However, kishk in amounts more than 20% affected adversely the aroma, taste and texture, as well as volatile compounds of the biscuits. Both the control and fortified with kishk biscuits contained an increased amount of total phenolic compounds. Based on sensory evaluation and volatile analysis, the most acceptable amount of kishk for fortification of biscuit was 10%.
Conclusion. Fortification of biscuit with Egyptian kishk enhanced its protein, fat and fiber, as well as antioxidant activity at all levels of fortification with no significant effect on appearance and color. Further studies are needed to evaluate storage conditions and shelf life of biscuits with kishk.
Minced products from undersized sea fish: new industrial technology
Authors: Gorbatovskiy Andrey , Rakityanskaya Irina , Kaledina Marina 
Published: April 2021

Introduction. The ever-growing world population and protein deficiency increase the demand for products of animal origin, especially fish-based. However, canned foods and fillets, which are the most popular types of fish products, are made from medium-sized and large fish. In spite of the fact that undersized fish is cheap, it requires manual processing and remains so time and labour consuming that it is utilized for non-food purposes. The research objective was to develop a new technology for processing undersized sea fish into minced ready-to-eat products.
Study objects and methods. The study featured experimental samples of fish mince with texturing agents and food additives vs. control samples of pure fish mince. The experiment involved block-frozen Peruvian anchovy (Engraulis ringens L.). The anchovy was minced without pre-defrosting, gutting, or beheading. The experimental and control samples underwent sensory evaluation and were tested for moisture content, water-binding capacity, and rheological properties using a PNDP-penetrometer.
Results and discussion. Adding 3.6% of wheat fiber, ≤ 15% of pea flour, ≤ 10% of textured soy, and 12% of onion improved the sensory and technological profiles of the finished product. The recommended mass fraction of fish in the finished product did not exceed 55%, as a higher amount deteriorated the sensory quality of the product. The textured soy provided the optimal texture. The fish balls were cooked from the fish mince, which were deep-fried in breadcrumbs, received a high score for sensory properties and could be recommended as basis for various formulations.
Conclusion. Minced undersized fish, traditionally used as fertilizers or crude product, proved to be an advantageous semi-finished and ready-to-eat product. The developed technology is relevant for most undersized block-frozen sea fish.
Использование методики «Сетевой самоотчет» для изучения специфики интернет-социализации подростков и юношей с нарушением интеллекта
Authors: Кузьмина Татьяна И. 
Published: April 2021

Введение. Изучение специфики сетевой социализации подростков и юношей с ОВЗ и, в частности, с нарушением интеллекта является новым и перспективным направлением в специальной психологии и нуждается в разработке методологических подходов и методических основ проведения исследований подобного рода.
Методы. Изучение специфики сетевой социализации лиц с нарушением интеллекта связано с описанием особенностей их социализационно-сетевого становления, в сравнении с нормативно развивающимися сверстниками предполагающим понимание исследователем интернет-взаимодействия как формы альтернативной коммуникации, способа адаптации и потенциального источника сетевых рисков личности. Методический инструментарий представлен авторской методикой «Сетевой самоотчет», апробированной с участием 181 респондента подросткового и юношеского возраста с нормативным развитием и 119 респондентов тех же возрастов с нарушением интеллекта.
Результаты. Апробация методики «Сетевой самоотчет» с участием выборок подростков и юношей с умственной отсталостью и их нормативно развивающихся сверстников показала, что данный инструментарий доступен для выполнения респондентам обеих групп и применим для выявления качественно-количественных различий между выборками. У респондентов с умственной отсталостью наблюдаются меньшая активность в Сети по поиску информации, низкая осведомленность о сетевых явлениях и феноменах сетевого взаимодействия, использование Интернета как дополнительного поля реализации выраженной потребности в общении и более агрессивная защита своего сетевого пространства от вмешательства родителей.
Обсуждение результатов. Представленные данные открывают ряд перспективных направлений исследования в предметной области сетевой социализации обучающихся с нарушением развития: 1) первичный скрининг в рамках ведущего нарушения по сравнению с нормативно развивающимися сверстниками; 2) углубленное исследование по возрастным диапазонам в рамках одной нозологии и выявление возрастных различий внутри одной нозологической группы; 3) дифференцированное исследование по сравнению разных нозологических категорий и выявлению межгрупповых различий.
Особенности жизненного мира юношей и девушек разных возрастных периодов
Authors: Яремчук Светлана В. , Бакина Анна В. , Ситяева Снежана М. 
Published: April 2021

Введение. Переход от юности к молодости является важным этапом в развитии личности, в котором изменяется восприятие окружающей действительности и жизненного мира. Но эмпирических исследований, посвященных данной проблеме, очень мало. Новизна данного исследования заключается в изучении жизненного мира юношей и девушек разных возрастных групп. В основу исследования положена концепция Ф. Е. Василюка, который выделяет внешний и внутренний аспекты жизненного мира и их основные характеристики: легкость/трудность внешнего мира; простота/сложность внутреннего.
Методы. Использована методика графического представления жизненного психологического пространства Г. В. Шуковой для оценки многосоставности мира как критерия его простоты/сложности. Для оценки легкости/трудности жизненного мира были использованы три методики: 1) модифицированная методика А. Б. Купрейченко для оценки субъективной удаленности предметов потребности; 2) методика Е. Б. Фанталовой «Уровень соотношения “ценности” и “доступности” в различных жизненных сферах» для определения субъективной трудности достижения значимых объектов; и 3) методика оценки глобальной удовлетворенности жизнью и субъективного уровня счастья для общей оценки субъективной трудности мира.
Результаты. Результаты исследования показали, что у юношей и девушек в 16–17 лет жизненные миры являются сходными как по критерию простоты/сложности их внутреннего мира, так и по показателям легкости/трудности внешнего. В возрасте 18–22 года девушки имеют более сложный и дифференцированный внутренний мир, чем юноши, у которых пространство жизненного мира к этому возрасту упрощается. Различия в этом возрасте также проявляются в том, что девушки менее удовлетворены жизнью и счастливы, что связано с увеличением для них субъективной трудности их жизненного мира.
Обсуждение результатов. Обсуждается кризисный характер перестройки жизненного мира, происходящей у юношей и девушек с привлечением различных способов преобразования субъективной реальности.
Determination of Hybrid TSPO Ligands with Minimal Impact of SNP
(rs6971) through Molecular Docking and MD Simulation Study
Authors: Adhikari Anupriya , Pandey Anwesh , Kumar Devesh , Tiwari Anjani K. 
Published: April 2021

Background:
In an endeavor to ascertain high-affinity TSPO ligands with minimal single
nucleotide polymorphism (SNP), six hybrid molecules have been identified as new leads for future
inflammation PET imaging.

Objective:
Genesis for chemical design was encouraged from structural families of well-known ligands
FEBMP and PBR28/ DAA1106 that have demonstrated remarkable TSPO binding characteristics.

Methods:
All proposed hybrid ligands 1-6 are subjected to molecular docking and simulation studies
with wild and mutant protein to study their interactions, binding, consistency of active conformations
and are correlated with well-established TSPO ligands.

Results:
Each hybrid ligand demonstrate better docking score > -11.00 kcal/mol with TSPO with
respect to gold standard PK11195, i.e., -11.00 kcal/mol for 4UC3 and -12.94 kcal/mol for 4UC1. On
comparison with FEBMP and GE-180 (-12.57, -7.24 kcal/mol for 4UC3 and -14.10, -11.32
kcal/mol for 4UC1), ligand 3 demonstrates maximum docking energy (> -15.50 kcal/mol) with
minimum SNP (0.26 kcal/mol).

Discussion:
Presence of strong hydrogen bond Arg148-3.27Å (4UC1) and Trp50-2.43Å, Asp28-
2.57Å (4UC3) apart from short-range interactions, including π–π interactions with the aromatic residues,
such as (Trp39, Phe46, Trp135) and (Trp39, Trp108), attributes towards its strong binding.

Conclusion:
Utilizing the results of binding energy, we concluded stable complex formation of these
hybrid ligands that could bind to TSPO with the least effect of SNP with similar interactions to
known ligands. Overall, ligand 3 stands out as the best ligand having insignificant deviations per
residue of protein that can be further explored and assessed in detail for future inflammation PET
application after subsequent detailed biological evaluation.
Identification of Novel Nrf2 Activator via Protein-ligand Interactions as
Remedy for Oxidative Stress in Diabetes Mellitus
Authors: Onunkun Afolashade Toritseju , Iwaloye Opeyemi , Elekofehinti Olusola Olalekan 
Published: April 2021

Background:
Oxidative stress is a significant player in the pathogenesis of diabetes mellitus
and the Kelch-like ECH-associated protein1/nuclear factor erythroid 2-related factor 2/antioxidant response
element (Keap1/Nrf2/ARE) signaling pathway serves as the essential defense system to mitigate
oxidative stress. Nrf2 is responsible for the mitigation of oxidative stress while Keap1 represses Nrf2’s
activation upon binding. Identification of Nrf2 activators has started to pick up enthusiasm as they can be
used as therapeutic agents against diabetes mellitus. One of the ongoing mechanisms in the activation of
Nrf2 is to disrupt Keap1/Nrf2 protein-protein interaction. This study aimed at using computational analysis
to screen natural compounds capable of inhibiting Keap1/Nrf2 protein-protein interaction.

Methods:
A manual curated library of natural compounds was screened against crystal structure of Keap1
using glide docking algorithm. Binding free energy of the docked complexes, and adsorption, digestion,
metabolism and excretion (ADME) properties were further employed to identify the hit compounds. The
bioactivity of the identified hit against Keap1 was predicted using quantitative structure-activity relationship
(QSAR) model.

Results:
A total of 7 natural compounds (Compound 222, 230, 310, 208, 210, 229 and 205) identified
from different medicinal plants were found to be potent against Keap1 based on their binding affinity and
binding free energy. The internal validated model kpls_radial_30 with R2 of 0.9109, Q2 of 0.7287 was
used to predict the compounds’ bioactivities. Compound 205 was considered as the ideal drug candidate
because it showed moderation for ADME properties, had predicted pIC50 of 6.614 and obeyed Lipinski’s
rule of five.

Conclusion:
This study revealed that Compound 205, a compound isolated from Amphipterygium adstringens
is worth considering for further experimental analysis.