bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acral Changes in pediatric patients during COVID 19 pandemic: Registry report from the COVID 19 response task force of the society of pediatric dermatology (SPD) and pediatric dermatology research alliance (PeDRA)
Authors: Castelo‐Soccio Leslie , Lara‐Corrales Irene , Paller Amy S. , Bean Eric , Rangu Sneha , Oboite Michelle , Flohr Carsten , Ahmad Regina‐Celeste , Calberg Valerie , Gilliam Amy , Pope Elena , Reynolds Sean , Sibbald Cathryn , Shin Helen T. , Berger Emily , Schaffer Julie , Siegel Michael P. , Cordoro Kelly M. 
Published: March 2021

AbstractBackground/ObjectiveIn spring 2020, high numbers of children presented with acral pernio‐like skin rashes, concurrent with the coronavirus disease 2019 (COVID‐19) pandemic. Understanding their clinical characteristics/ infection status may provide prognostic information and facilitate decisions about management.MethodsA pediatric‐specific dermatology registry was created by the Pediatric Dermatology COVID‐19 Response Task Force of the Society for Pediatric Dermatology (SPD) and Pediatric Dermatology Research Alliance (PeDRA) and was managed by Children's Hospital of Philadelphia using REDCap.ResultsData from 378 children 0‐18 years entered into the registry between April 13 and July 17, 2020 were analyzed. Data were drawn from a standardized questionnaire completed by clinicians which asked for demographics, description of acral lesions, symptoms before and after acral changes, COVID‐19 positive contacts, treatment, duration of skin changes, laboratory testing including SARS‐CoV‐2 PCR and antibody testing, as well as histopathology. 229 (60.6%) were male with mean age of 13.0 years (± 3.6 years). Six (1.6%) tested positive for SARS‐CoV‐2. Pedal lesions (often with pruritus and/or pain) were present in 96%. 30% (114/378) had COVID‐19 symptoms during the 30 days prior to presentation. Most (69%) had no other symptoms and an uneventful course with complete recovery.Conclusions and RelevanceChildren with acral pernio‐like changes were healthy and all recovered with no short‐term sequelae. We believe these acral changes are not just a temporal epiphenomenon of shelter in place during the spring months of the first wave of the COVID‐19 pandemic and may be a late phase reaction that needs further study.
Combined liver kidney transplantation for primary hyperoxaluria type 1: Will there still be a future? Current transplantation strategies and monocentric experience
Authors: Tandoi Francesco , Cussa Davide , Peruzzi Licia , Catalano Silvia , Camilla Roberta , Mandrile Giorgia , Calvo Pier Luigi , Pinon Michele , Dell’Olio Dominic , Salizzoni Mauro , Amoroso Antonio , Romagnoli Renato 
Published: March 2021

AbstractCombined liver–kidney transplantation is a therapeutic option for children affected by type 1 primary hyperoxaluria. Persistently high plasma oxalate levels may lead to kidney graft failure. It is debated whether pre‐emptive liver transplantation, followed by kidney transplantation, might be a better strategy to reduce kidney graft loss. Our experience of 6 pediatric combined liver–kidney transplants for primary hyperoxaluria type 1 in pediatric recipients was retrospectively analyzed. Plasma oxalate levels were monitored before and after transplantation. All the recipients were on hemodialysis at transplantation. Median [IQR] recipient's age at transplantation was 11 [1–14] years; in all cases, a compatible graft from a pediatric brain‐dead donor aged 8 [2–16] years was used. In a median follow‐up of 7 [2–19] years after combined liver–kidney transplantation, no child died and no liver graft failure was observed; three kidney grafts were lost, due to chronic rejection, primary non‐function, and early renal oxalate accumulation. Liver and kidney graft survival remained stable at 1, 3, and 5 years, at 100% and 85%, respectively. Kidney graft loss was the major complication in our series. Risk is higher with very young, low‐weight donors. The impact of treatment with glyoxalate pathway enzyme inhibitors treatment in children with advanced disease as well as of donor kidney preservation by ex vivo machine perfusion needs to be evaluated. At present, a case‐by‐case discussion is needed to establish an optimal treatment strategy.
Use of eltrombopag for the treatment of poor graft function after hematopoietic stem cell transplantation in children
Authors: Uria‐Oficialdegui M. Luz , Alonso Laura , Benitez‐Carabante M. Isabel , Renedo Berta , Oliveras Maria , Diaz‐de‐Heredia Cristina 
Published: March 2021

AbstractThe main objective of this study was to determine whether Eltrombopag, a synthetic thrombopoietin receptor agonist, could improve peripheral blood counts in the three hematopoietic lineages and achieve transfusion independence in children with poor graft function (PGF) after allogenic hematopoietic stem cell transplantation (HSCT). Retrospective study of patients under 18 years who developed PGF post‐HSCT in a large tertiary institution between January 2013 and March 2019. Out of 198 allogeneic HSCT, five patients met PGF criteria and were treated with eltrombopag. Median time from HSCT to eltrombopag initiation was 120 days. The median starting dose was 50 mg/day and the maximum dose reached was 75 mg/day. Median treatment duration was 9 months. Three patients achieved complete response and one partial response. The median dose among responders was 75 mg/day and the median time to response 8 weeks. Responses were sustained in three patients and two required a booster dose of CD34+‐selected cells from the original donor. None of the patients had to stop treatment due to adverse effects. The use of eltrombopag in children with PGF achieved responses in 80% of cases and demonstrated to be an effective and safe therapeutic option in pediatric patients with PGF.
Micromorphological and phytochemical survey of Ballota acetabulosa (L.) Benth
Authors: Giuliani C. , Bottoni M. , Ascrizzi R. , Milani F. , Falsini S. , Papini A. , Flamini G. , Fico G. 
Published: March 2021

Abstract

Within the Open Science project entitled ‘Botanic Garden, factory of molecules’, a multidisciplinary study approach was applied to Ballota acetabulosa (L.) Benth., at the Ghirardi Botanic Garden (Toscolano Maderno, BS, Italy).

Micromorphological and histochemical investigations were performed on the secreting structures of the vegetative and reproductive organs under light, fuorescence and electronic microscopy. Concurrently the characterization of the volatiles spontaneously emitted from leaves and flowers were examined.

Four trichome morphotypes were identified: peltate and short‐stalked, medium‐stalked and long‐stalked capitate trichomes, each with a specific distribution pattern. The histochemical analysis was confirmed using ultrastructural observations, with the peltates and long‐stalked capitates as the main sites responsible for terpene production. The head‐space characterization revealed that sesquiterpene hydrocarbons dominated both in leaves and flowers, with γ‐muurolene, β‐caryophyllene and (E)‐nerolidol as the most abundant compounds. Moreover, a comparison with literature data concerning the ecological roles of the main compounds suggested their dominant roles in defence, both at the leaf and flower level.

Hence, we correlated the trichome morphotypes with the production of secondary metabolites in an attempt to link these data to their potential ecological roles. Finally, we made the obtained scientific knowledge available to visitors of the Botanic Garden through the realization of new labelling dedicated to B. acetabulosa that highlights the ‘invisible’, microscopic features of the plant.
Integrating multimedia documents and time‐evolving 3D city models for web visualization and navigation
Authors: Jaillot Vincent , Rigolle Valentin , Servigne Sylvie , Samuel John , Gesquière Gilles 
Published: March 2021

AbstractMany geographic features such as 3D city models, real‐time sensor data and multimedia documents (photo, audio, video, etc.) are nowadays available for describing urban areas. These heterogeneous geographic features are multidimensional (spatial, thematic and temporal), can have multiple representations (text, iconography, etc.) and can be modeled using diverse formats. Browsing and crossing these features can help us to analyze and understand the past and present and plan the future evolution of cities. Furthermore, doing so in a web context allows us to share and enrich them in a collective way. In this article we propose a new generic model (GenLinkable) for integrating such features. We also propose the Gen4DCity‐Doc model which specifies GenLinkable to integrate multimedia documents and time‐evolving 3D city models for web visualization and navigation. Gen4DCity‐Doc extends previous research results by integrating new resources describing cities (multimedia documents). Gen4DCity‐Doc is implemented in a web prototype based on a four‐tier architecture using and enhancing open source software and standards. Finally, we also demonstrate that these models open up new navigation possibilities in 3D city models and in multimedia documents through a 3D web interface, which is a current challenge, especially to help researchers in urban history.
Integration by Parts: Collaboration and Topic Structure in the CogSci Community
Authors: DeStefano Isabella , Oey Lauren A. , Brockbank Erik , Vul Edward 
Published: March 2021

AbstractIs cognitive science interdisciplinary or multidisciplinary? We contribute to this debate by examining the authorship structure and topic similarity of contributions to the Cognitive Science Society from 2000 to 2019. Our analysis focuses on graph theoretic features of the co‐authorship network—edge density, transitivity, and maximum subgraph size—as well as clustering within the space of scientific topics. We also combine structural and semantic information with an analysis of how authors choose their collaborators based on their interests and prior collaborations. We compare findings from CogSci to abstracts from the Vision Science Society over the same time frame and validate our approach by predicting new collaborations in the 2020 CogSci proceedings. Our results suggest that collaboration across authors and topics within cognitive science has become increasingly integrated in the last 19 years. More broadly, we argue that a formal quantitative approach which combines structural co‐authorship information and semantic topic analysis provides inroads to questions about the level of interdisciplinary collaboration in a scientific community.
Retrospective review of diphenhydramine versus diphenhydramine plus glucocorticoid for treatment of uncomplicated allergic reaction in dogs
Authors: Helgeson Megan E. , Pigott Armi M. , Kierski Kate R. 
Published: March 2021

AbstractObjectiveTo report the outcome of treatment of uncomplicated allergic reactions in dogs with diphenhydramine vs diphenhydramine plus glucocorticoid and to determine the incidence rate of uncomplicated allergic reactionsDesignRetrospective study between January 1, 2012 and August 15, 2018.SettingPrivately owned, 24‐hour emergency and specialty referral veterinary hospital.AnimalsEight hundred and eighty cases of dogs treated for uncomplicated allergic reaction with diphenhydramine alone or in combination with a glucocorticoid.InterventionsNone.Measurements and main resultsTwo hundred ninety‐nine dogs were treated with diphenhydramine alone, and 581 were treated with diphenhydramine plus Dex SP. There was no difference between the 2 groups for response to initial therapy, need for additional veterinary intervention after discharge, or persistent signs at follow‐up. The cumulative incidence of emergency department presentation for uncomplicated allergic reaction in this hospital was 1.2%.ConclusionsThere was no difference in measured outcomes between dogs treated with diphenhydramine alone vs those treated with a glucocorticoid in addition to diphenhydramine in this population of dogs.
Preventing the cross‐border spread of zoonotic diseases: Multisectoral community engagement to characterize animal mobility—Uganda, 2020
Authors: Medley Alexandra Marie , Gasanani Jonan , Nyolimati Ceaser Adibaku , McIntyre Elvira , Ward Sarah , Okuyo Bosco , Kabiito Duncan , Bender Cristel , Jafari Zainab , LaMorde Mohammed , Babigumira Peter Ahabwe , Nakiire Lydia , Agwang Constance , Merrill Rebecca , Ndumu Deo , Doris Kiconco 
Published: March 2021

AbstractIn Uganda, the borders are highly porous to animal movement, which may contribute to zoonotic disease spread. We piloted an animal adaptation of an existing human‐focused toolkit to collect data on animal movement patterns and interactions to inform One Health programs. During January 2020, we conducted focus group discussions and key informant interviews with participatory mapping of 2 national‐level One Health stakeholders and 2 local‐level abattoir representatives from Kampala. Zoonotic disease hotspots changed in 2020 compared with reports from 2017–2019. In contrast to local‐level participants, national‐level participants highlighted districts rather than specific locations. Everyone discussed livestock species; only national‐level participants mentioned wildlife. Participants described seasonality differently. Stakeholders used the results to identify locations for zoonotic disease interventions and sites for future data collection. This implementation of an animal‐adapted population mobility mapping exercise highlights the importance of multisectoral initiatives to promote One Health border health approaches.
Effects of shockwave therapy on pain and disability in individuals with rotator cuff tendinopathy: a systematic review protocol
Authors: Tang Zhi Yin , Wee Jewel Jing Yi , Lim Hanniel Han Rong 
Published: March 2021

ABSTRACT

Objective:
The objective of this study is to systematically review randomized controlled trials comparing the effect of shockwave therapy with other forms of interventions on pain and disability in individuals with rotator cuff tendinopathy.

Introduction:
Shoulder pain is a common musculoskeletal complaint in which rotator cuff tendons are usually affected. Shockwave therapy is a novel conservative treatment option for rotator cuff–related shoulder pain. A systematic review in 2004 reported conflicting results on the effectiveness of shockwave therapy in treating chronic rotator cuff tendonitis, whereby it is effective for calcific rotator cuff tendonitis but not for non-calcific ones. Hence, it is timely to review this topic with the addition of results from studies published since 2004.

Inclusion criteria:
This review will consider randomized controlled trials that have evaluated shockwave therapy delivered via radial or focused extracorporeal means in individuals with rotator cuff tendinopathy without restrictions of race, gender, and age. Studies comparing individuals receiving shockwave therapy of varying dosages will be excluded in this review.

Methods:
A three-step search strategy will be used to locate studies published in English from databases. No search restrictions will be applied regarding the year of publication. Study selection, assessment of methodological quality, and data extraction will be conducted by two independent reviewers. Data will be pooled in a statistical meta-analysis, where possible. A funnel plot will be generated to detect any potential publication bias. The quality of the evidence will be analyzed using the Grading of Recommendations, Assessment, Development, and Evaluation approach.

Systematic review registration number:
PROSPERO CRD42020160166.
Digital Twin-Driven Rapid Customized Design of Board-Type Furniture Production Line
Authors: Yan Douxi , Liu Qiang , Leng Jiewu , Zhang Ding , Zhao Rongli , Zhang Hao , Wei Lijun 
Published: March 2021

Abstract
The mass personalization paradigm requires manufacturing enterprises to adapt to market changes quickly to meet customer demands. It also imposes higher requirements for designing intelligent production lines. Based on the digital twin (DT) technology, a rapid customized design method is proposed for developing new board-type furniture production lines. The DT has the characteristics of interactive virtual-reality mapping and fusion. It could provide design guidance and decision-support services in the design phase, yield the engineering analyzing ability to solve coupled problems, and finally generate the authoritative design scheme of the manufacturing system. A production line design platform is developed based on the DT model, which can parallelize the design process and reduce the design cycle. The parallel control between the physical world and digital space is achieved by establishing the DT network and perceiving the status of the physical equipment. Five key enabling technologies are introduced to provide the theoretical fundamentals for implementing the DT-based manufacturing system design approach. A board-type furniture production line is presented as a case study to verify the effectiveness of the method.
Survey protocol for exploring video and phone use in Aotearoa New Zealand general practice: considerations for future telehealth
Authors: Day Karen , Hunter Inga , Rao Vasudha , Russell Greig , Roskvist Rachel , Moir Fiona , Gill Emily , van der Werf Bert 
Published: March 2021

IntroductionTelehealth became the most practical option for general practice consultations in Aotearoa New Zealand (NZ) as a result of the national lockdowns in response to the COVID-19 pandemic. What is the consumer experience of access to telehealth and how do consumers and providers perceive this mode of care delivery going forward?Methods and analysisA national survey of general practice consumers and providers who used telehealth services since the national lockdowns in 2020 will be distributed. It is based on the Unified Theory of Acceptance and Use of Technology framework of technology acceptance and the access to care framework. The data will be statistically analysed to create a foundation for in-depth research on the use of telehealth services in NZ general practice services, with a specific focus on consumer experiences and health outcomes.Ethics and disseminationEthics approval was granted by the Auckland Health Research Ethics Committee on 13/11/2020, reference AH2539. The survey will be disseminated online.
What matters most and for whom? A cross-sectional study exploring goals of health professionals in German neonatal intensive care units
Authors: Mensen Anne , Roth Bernhard , Kuntz Ludwig , Wittland Michael , Glöckner Verena , Miedaner Felix 
Published: March 2021

ObjectivesQuality of care largely depends on successful teamwork, which in turn needs effective communication between health professionals. To communicate successfully in a team, health professionals need to strive for the same goals. However, it has been left largely unaddressed which goals professionals consider to be important. In this study, we aim to identify these goals and analyse whether differences between (1) personal and organisational goals, (2) different professions and (3) hierarchical levels exist in neonatal intensive care units (NICUs).DesignGoals were identified based on a literature review and a workshop with health professionals and tested in a pilot study. Subsequently, in the main study, a cross-sectional employee survey was undertaken.Setting and participants1489 nurses and 537 physicians from 66 German NICUs completed the questionnaire regarding personal and organisational goal importance between May and July 2013. Answers were given based on a 7-point Likert scale varying between none and exceptionally high importance.ResultsResults show that the goals can be subdivided into three main goal dimensions: patients, parents and staff. Furthermore, our results reveal significant differences between different professions and different hierarchical level: physicians rated patient goals with a mean (95% CI) importance of 6.37 (6.32 to 6.43), which is significantly higher than nurses with a mean (95% CI) importance of 6.15 (6.12 to 6.19) (p<0.01). Otherwise, nurses classified parental goals as more important (p<0.01). Furthermore, professionals in leading positions rate patient goals significantly higher than professionals that are not in leading positions (6.36 (6.28 to 6.44) vs 6.19 (6.15 to 6.22), p<0.01).ConclusionsDifferent employee goals need to be considered in decision-making processes to enhance employee motivation and the effectiveness of teamwork.Trial registration numberDRKS00004589.
Decision Analysis in SHared decision making for Thromboprophylaxis during Pregnancy (DASH-TOP): a sequential explanatory mixed methods pilot study protocol
Authors: Humphries Brittany , León-García Montserrat , Bates Shannon , Guyatt Gordon , Eckman Mark , D"Souza Rohan , Shehata Nadine , Jack Susan , Alonso-Coello Pablo , Xie Feng 
Published: March 2021

IntroductionDecision analysis is a quantitative approach to decision making that could bridge the gap between decisions based solely on evidence and the unique values and preferences of individual patients, a feature especially important when existing evidence cannot support clear recommendations and there is a close balance between harms and benefits for the treatments options under consideration. Low molecular weight heparin (LMWH) for the prevention of venous thromboembolism (VTE) during pregnancy represents one such situation. The objective of this paper is to describe the rationale and methodology of a pilot study that will explore the application of decision analysis to a shared decision-making process involving prophylactic LMWH for pregnant women or those considering pregnancy who have experienced a VTE.Methods and analysisWe will conduct an international, mixed methods, explanatory, sequential study, including quantitative data collection and analysis followed by qualitative data collection and analysis. In step I, we will ask women who are pregnant or considering pregnancy and have experienced VTE to participate in a shared decision-making intervention for prophylactic LMWH. The intervention consists of three components: a direct choice exercise, a values elicitation exercise and a personalised decision analysis. After administration of the intervention, we will ask women to make a treatment decision and measure decisional conflict, self-efficacy and satisfaction. In step II, which follows the analysis of quantitative data, we will use the results to inform the qualitative interview. Step III will be a qualitative descriptive study that explores participants’ experiences and perceptions of the intervention. In step IV, we will integrate findings from the qualitative and quantitative analyses to obtain meta-inferences.Ethics and disseminationSite-specific ethics boards have approved the study. All participants will provide informed consent. The research team will take an integrated approach to knowledge translation.