bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recreation department from the students' perspective: A SWOT analysis
Authors: Ayyıldız Durhan Tebessüm , Kurtipek Serkan , Güngör Nuri Berk 
Published: May 2021

The aim of this study is to determine the strengths, weaknesses, threats and opportunities of the recreation department from the students' perspective. In the research prepared with qualitative method, case study design was used. The study group of the study consists of 36 students studying at the recreation department of the sports sciences faculty in a state university in Ankara in 2021. In the research, semi-structured interview form was used as data collection tool and descriptive analysis technique was used in the analysis of the obtained data. Accordingly, the data were collected under 4 themes and 19 categories. As a result, it is seen that most of the participants stated the increase in the need for recreational activities (f = 17) as the strength of the department, and the insufficient recognition of the recreation concept and its section (f = 28) as the weaknesses of the department. While the participants also consider the diversity of job opportunities (f = 14) as an opportunity for the recreation department, it can be stated that they perceive the high number of departments and graduates (f = 25) as a threat to the department.

Özet

Bu çalışmanın amacı öğrencilerin bakış açısıyla rekreasyon bölümünün güçlü yönlerinin, zayıf yönlerinin, tehditlerinin ve fırsatlarının belirlenmesidir. Nitel yöntemle hazırlanan araştırmada, durum çalışması deseninden yararlanılmıştır. Araştırmanın çalışma grubunu 2021 yılında Ankara ilinde bir devlet üniversitesinde spor bilimleri fakültesine bağlı rekreasyon bölümünde öğrenim gören toplam 36 öğrenci oluşturmaktadır. Araştırmada veri toplama aracı olarak yarı yapılandırılmış görüşme formu kullanılmış ve elde edilen verilerin analizinde betimsel analiz tekniği uygulanmıştır. Bu doğrultuda veriler 4 tema 19 kategori altında toplanmıştır. Sonuç olarak, katılımcıların büyük bir kısmının rekreatif faaliyetlere duyulan ihtiyacın artmasını (f=17) bölümün güçlü yönü olarak değerlendirirken, rekreasyon kavramının ve bölümünün yeterince tanınmamasını (f=28) ise bölümün zayıf yönleri olarak belirttikleri görülmektedir. Katılımcılar ayrıca iş imkanının çeşitliliğini (f=14) rekreasyon bölümü için fırsat olarak değerlendirirken, bölüm sayısının fazla olması ve çok sayıda mezun vermesini (f = 25) ise bölüm için tehdit olarak algıladıkları ifade edilebilir.
PENGEMBANGAN JALUR PEJALAN KAKI DI KAWASAN TOD DUKUH ATAS JAKARTA
Authors: Rakhmatulloh Anita Ratnasari , Kusumo Dewi Diah Intan 
Published: May 2021

Transit Oriented Development (TOD) merupakan salah satu konsep pengembangan transportasi berkelanjutan yang mempertimbangkan integrasi tinggi antar kawasan dan meningkatkan peluang pergerakan masyarakat kota. Dukuh Atas menjadi embrio pembanguan TOD di Indonesia dengan konsep walkable city dengan sistem road diet yang menekanakan kepada aspek lingkungan dan kenyamanan individu. Penelitian ini bertujuan untuk menemukan variabel pengembangan jalur pejalan kaki yang dapat mempengaruhi frekuensi seseorang untuk berjalan di TOD Dukuh Atas dari aspek lingkungan maupun karakteristik individunya. Pengumpulan data karakteristik individu dilakukan dengan metode pengumpulan data primer menggunakan kusioner yang disebar secara acak ke 300 responden kawasan TOD Dukuh Atas Jakarta. Data karakteristik lingkungan didapatkan dengan pengumpulan data sekunder dan data spasial melalui citra satelit untuk melihat kondisi terkini. Analisis data menggunakan metode analisis deskriptif statistik dan regresi linier uji T parsial didapatkan hasil berupa pendapatan, maksud perjalanan, dan kepadatan permukiman dapat mempengaruhi frekuensi pejalan kaki di kawasan TOD Dukuh Atas Jakarta.
THE IMAGE OF KAMPUNG BALUWARTI AS A JAVANESE CULTURAL EDU-TOURISM DESTINATION BASED ON THE CULTURE OF SURAKARTA SUNANATE PALACE
Authors: Saeroji Amad , Agfianto Tomi , Wijaya Deria Adi , Priyo Joko Sadoso , Marimin M 
Published: May 2021

Kampung Baluwarti is a cultural edu-tourism destination in Surakarta City, Central Java, Indonesia. Systematically, this study aims to: 1) identify the characteristics of the tourism products of Kampung Baluwarti; 2) study the development strategies of the image of Kampung Baluwarti as a cultural edu-tourism destination in Surakarta and formulate the cultural education tour packages that are tailored to existing potentials, environment, and regional planning. The research applied a descriptive-qualitative method with PASOLP (Product Analysis of Outdoor Leisure Planning Sequence) which offers a creative, pragmatic, and operational approach to modern tourism area planning. In this case, the research conducted two PASOLP stages: defining the object and attraction and providing recommendations on the needs and priorities. The data collection technique was conducted by collecting the necessary information through interviews with key informants. Field observation carried out the existing condition. Besides, a literature study was used to dig up literary information related to Kampung Baluwarti that was not obtained in interviews and observation. Besides, a literature study was used to explore literary information related to Kampung Baluwarti that was not obtained in interviews and observation. The results show that the tourism products, in this case, have multiple roles: not only for conservation and preservation purposes but also for improving the economy of the local people living in the area. Development strategies that are tailored to product characteristics, local community conditions, and planning are formulated with Javanese traditional tour packages that can form the image of Kampung Baluwarti as a cultural edu-tourism destination in Surakarta. Therefore, cultural edu-tourism destination carries the appropriate concept in developing tourism strategies based on the Javanese culture of Surakarta Sunanate Palace.
Increased RET Activity Coupled with a Reduction in theRETGene Dosage Causes Intestinal Aganglionosis in Mice
Authors: Okamoto Mitsumasa , Uesaka Toshihiro , Ito Keisuke , Enomoto Hideki 
Published: May 2021

AbstractMutations of the gene encoding theRETtyrosine kinase causes Hirschsprung’s disease (HSCR) and medullary thyroid carcinoma (MTC). Current consensus holds that HSCR and MTC are induced by inactivating and activating RET mutations, respectively. However, it remains unknown whether activating mutations in theRETgene have adverse effects on ENS developmentin vivo. We addressed this issue by examining mice engineered to express RET51(C618F), an activating mutation identified in MTC patients. AlthoughRet51(C618F)/51(C618F)mice displayed hyperganglionosis of the ENS,Ret51(C618F)/-mice exhibited severe intestinal aganglionosis because of premature neuronal differentiation. Reduced levels of glial cell-derived neurotrophic factor (GDNF), a RET-activating neurotrophic factor, ameliorated the ENS phenotype ofRet51(C618F)/-mice, demonstrating that GDNF-mediated activation of RET51(C618F) is responsible for severe aganglionic phenotype. TheRET51(C618F)allele showed genetic interaction withEdnrbgene, one of modifier genes for HSCR. These data reveal that proliferation and differentiation of ENS precursors are exquisitely controlled by both the activation levels and total dose of RET. Increased RET activity coupled with a decreased gene dosage can cause intestinal aganglionosis, a finding that provides novel insight into HSCR pathogenesis.
Teorijski pristupi i recepcijski učinci bajki
Authors: Bistrić Marija , Ivon Katarina 
Published: May 2021

Bajka kao najpopularniji usmenoknjiževni oblik u dječjoj književnosti prati dijete na putu njegova odrastanja i sazrijevanja, ujedno je jedan od načina da se djetetu pruži prvi dodir s književnošću. Bliska djetetu svojom strukturom te pogledom na život, bajka omogućuje djetetu upoznavanje svijeta i ljudi oko sebe te njihovih međusobnih odnosa. Bajka razvija maštu, sukonstruira postojeća znanja, gradi socijalne odnose te pomaže djetetu u rješavanju određenih problemskih situacija. U radu će se prikazati različite teorijske definicije i pristupi bajkama s posebnim fokusom na psihoanalitičku teoriju i teorijska razmatranja o načinima i mogućnostima učinaka bajki na dijete.
Stavovi roditelja predškolske djece prema inkluziji
Authors: Ninković Budimlija Helena , Cepanec Maja , Šimleša Sanja 
Published: May 2021

Broj je djece s teškoćama koja se u skladu s praksom inkluzije uključuju u redovne vrtićke programe sve veći. Stavovi su roditelja djece uključene u proces inkluzije važni, kako zbog znatne uloge koju roditelji imaju u samoj inkluziji, tako i zbog uloge roditelja u formiranju stavova vlastite djece. Stoga su ciljevi ovoga rada bili: 1) utvrditi mjeru pozitivnosti stavova roditelja predškolske djece urednoga razvoja prema uključivanju i boravku djece s teškoćama u predškolskim ustanovama; 2) utvrditi postoje li razlike između stavova roditelja prema uključivanju osoba s teškoćama u razvoju u odnosu na različite demografske varijable; 3) utvrditi postoje li razlike između stavova roditelja predškolske djece u odnosu na prethodna iskustva s djecom/osobama s teškoćama. U istraživanju je sudjelovalo 159 ispitanika/roditelja djece urednoga razvoja iz tri hrvatska grada (Gospić, Kastav i Pazin) smještena u tri različite županije (Ličko-senjska, Primorsko-goranska i Istarska županija). Upitnikom stavova roditelja prema inkluziji (SPATI) ispitani su: 1) opći stav prema inkluziji; 2) stav roditelja o utjecaju inkluzije na obrazovanje djeteta; 3) stav roditelja o utjecaju inkluzije na djetetove socijalne interakcije.Rezultati su pokazali da roditelji djece urednoga razvoja imaju prilično pozitivne stavove prema inkluziji, pri čemu su se posebno pozitivnima pokazali stavovi prema utjecaju inkluzije na socijalizaciju. Posebno je nagativan stav roditelja utvrđen u odnosu na utjecaj inkluzije na obrazovanje njihova djeteta. Nisu uočene znatne razlike između stavova roditelja u odnosu na spol, dob, socioekonomski status, veličinu grada u kojemu žive i broj djece u obitelji. No, iskustvo i kontakti s djecom s teškoćama pokazali su se kao čimbenik koji potencijalno može doprinijeti nešto negativnijem stavu prema inkluziji. Tako je utvrđeno da roditelji djece koja u skupini nemaju dijete s teškoćama imaju znatno pozitivniji stav o utjecaju inkluzije na obrazovanje svoje djece od roditelja čija djeca borave u skupini u kojoj se nalazi dijete s teškoćama.
Advances and challenges in quantitative delineation of the genetic architecture of complex traits
Authors: Tang Hua , He Zihuai 
Published: May 2021

BackgroundGenome‐wide association studies (GWAS) have been widely adopted in studies of human complex traits and diseases.ResultsThis review surveys areas of active research: quantifying and partitioning trait heritability, fine mapping functional variants and integrative analysis, genetic risk prediction of phenotypes, and the analysis of sequencing studies that have identified millions of rare variants. Current challenges and opportunities are highlighted.ConclusionGWAS have fundamentally transformed the field of human complex trait genetics. Novel statistical and computational methods have expanded the scope of GWAS and have provided valuable insights on the genetic architecture underlying complex phenotypes.
Population‐scale genetic control of alternative polyadenylation and its association with human diseases
Authors: Li Lei , Li Yumei , Zou Xudong , Peng Fuduan , Cui Ya , Wagner Eric J. , Li Wei 
Published: May 2021

BackgroundGenome‐wide association studies (GWAS) have identified thousands of genomic non‐coding variants statistically associated with many human traits and diseases, including cancer. However, the functional interpretation of these non‐coding variants remains a significant challenge in the post‐GWAS era. Alternative polyadenylation (APA) plays an essential role in post‐transcriptional regulation for most human genes. By employing different poly(A) sites, genes can either shorten or extend the 3′‐UTRs that contain cis‐regulatory elements such as miRNAs or RNA‐binding protein binding sites. Therefore, APA can affect the mRNA stability, translation, and cellular localization of proteins. Population‐scale studies have revealed many inherited genetic variants that potentially impact APA to further influence disease susceptibility and phenotypic diversity, but systematic computational investigations to delineate the connections are in their earliest states.ResultsHere, we discuss the evolving definitions of the genetic basis of APA and the modern genomics tools to identify, characterize, and validate the genetic influences of APA events in human populations. We also explore the emerging and surprisingly complex molecular mechanisms that regulate APA and summarize the genetic control of APA that is associated with complex human diseases and traits.ConclusionAPA is an intermediate molecular phenotype that can translate human common non‐coding variants to individual phenotypic variability and disease susceptibility.
Reducing Unnecessary Treatments for Acute Bronchiolitis Through an Integrated Care Pathway
Authors: Montejo Marta , Paniagua Natalia , Saiz-Hernando Carlos , Martínez-Indart Lorea , Pijoan Jose Ignacio , Castelo Susana , Martín Vanesa , Benito Javier 
Published: May 2021

OBJECTIVES:
To analyze the impact of an integrated care pathway on reducing unnecessary treatments for acute bronchiolitis.

METHODS:
We implemented an evidence-based integrated care pathway in primary care (PC) centers and the referral emergency department (ED). This is the third quality improvement cycle in the management of acute bronchiolitis implemented by our research team. Family and provider experiences were incorporated by using design thinking methodology. A multifaceted plan that included several quality improvement initiatives was adopted to reduce unnecessary treatments. The primary outcome was the percentage of infants prescribed salbutamol. Secondary outcomes were prescribing rates of other medications. The main control measures were hospitalization and unscheduled return rates. Salbutamol prescribing rate data were plotted on run charts.

RESULTS:
We included 1768 ED and 1092 PC visits, of which 913 (51.4%) ED visits and 558 (51.1%) PC visits occurred in the postintervention period. Salbutamol use decreased from 7.7% (interquartile range [IQR] 2.8–21.4) to 0% (IQR 0–1.9) in the ED and from 14.1% (IQR 5.8–21.6) to 5% (IQR 2.7–8) in PC centers. In the ED, the overall epinephrine use rate fell from 9% (95% confidence interval [CI], 7.2–11.1) to 4.6% (95% CI, 3.4–6.1) (P &lt; .001). In PC centers, overall corticosteroid and antibiotic prescribing rates fell from 3.5% (95% CI, 2.2–5.4) to 1.1% (95% CI, 0.4–2.3) (P =.007) and from 9.5% (95% CI; 7.3–12.3) to 1.7% (95% CI, 0.9–7.3) (P &lt;.001), respectively. No significant variations were noted in control measures.

CONCLUSIONS:
An integrated clinical pathway that incorporates the experiences of families and clinicians decreased the use of medications in the management of bronchiolitis.
An Evaluation of an Integrative Care Approach for End-Stage Renal Disease Patients
Authors: BIESEN WIM VAN , VANHOLDER RAYMOND C. , VEYS NIC , DHONDT ANNEMIEKE , LAMEIRE NORBERT H. 
Published: May 2021

Abstract.
Studies analyzing the outcome of integrative care of end-stage renal disease (ESRD) patients, whereby patients are transferred from one renal replacement modality to another according to individual needs, are scant. In this study, we analyzed 417 files of 223 hemodialysis (HD) and 194 peritoneal dialysis (PD) patients starting renal replacement therapy between 1979 and 1996, to evaluate the effect of such an approach. Analysis was done for survival of patients on their first modality, for intention-to-treat survival (counting total time on renal replacement therapy, but with exclusion of time on transplantation), and for total survival. Log rank analysis was used and correction for risk factors was performed by Cox proportional hazards regression. Intention-to-treat survival and total survival were not different between PD and HD patients (log rank, P > 0.05). Technique success was higher in HD patients compared to PD patients (log rank, P = 0.01), with a success rate after 3 yr of 61 and 48%, respectively. Thirty-five patients were transferred from HD to PD and 32 from PD to HD. Transfer of PD patients to HD was accompanied by an increase in survival compared to those remaining on PD (log rank, P = 0.001), whereas, in contrast, transfer of patients from HD to PD was not (log rank, P = 0.17). Survival of patients remaining more than 48 mo on their initial modality was lower for PD patients (log rank, P < 0.01). A matched-pair analysis between patients who started on PD and who were transferred to HD later (by definition called integrative care patients), and patients who started and remained on HD, showed a survival advantage for the integrative care patients. These results indicate that patient outcome is not jeopardized by starting patients on PD, at least if patients are transferred in a timely manner to HD when PD-related problems arise.
Kaposi's sarcoma of the penis in HIV-negative patients: case series
Authors: Ognerubov N. A. , Blokhin A. V. , Gumareva G. E. 
Published: May 2021

Kaposi's sarcoma is a malignant vascular tumor associated with human herpesvirus-8 (HHV-8). The disease primarily affects the skin, mucous membranes, lymph nodes, and even internal organs in late stages. Kaposi's sarcoma of the penis is usually found in patients infected with human immunodeficiency virus (HIV) and is exceedingly rare in HIV-negative patients.In this article, we report 2 cases of Kaposi's sarcoma in a 42-year-old and 55-year-old patients. Both patients denied any homosexual relationships. Their tumors were represented by 5-mm nodules located close to the external urethral orifice. Both patients have undergone tumor excision. Histological and immunohistochemical examinations demonstrated Kaposi's sarcoma. The 55-year-old-patient had positive nuclear staining with anti-HHV-8 antibodies in the tumor cells, although no anti-HIV antibodies were found in his serum. The 42-year-old patient had a clinically significant increase in the level of human papillomavirus 51 (HPV-51) DNA detected using polymerase chain reaction in his urethral swab sample (3.2 х 10 5 Lg). Both patients were alive after 36 and 34 months, respectively, without signs of disease progression.
Nephrectomy and thrombectomy in renal cell carcinoma patients with extensive tumor venous thrombosis: how to minimize surgical risks?
Authors: Matveev V. B. , Stilidi I. S. , Volkova M. I. , Vashakmadze N. L. , Klimov A. V. , Begaliev A. K. , Feoktistov P. I. , Kuznetsov K. P. , Davydov M. I. 
Published: May 2021

Objective: to evaluate the outcomes of thrombectomy performed using different surgical techniques in renal cell carcinoma (RCC) patients with extensive tumor venous thrombosis.Materials and methods. This study included 345 RCC patients with extensive tumor venous thrombosis who underwent surgical treatment.The median age was 57 years (range: 16—79 years); the male-to-female ratio was 1:1.9. Two hundred and sixty patients (75.4 %) had their tumor thrombus originating from the right renal vein, 85 patients (24.6 %) — from the left renal vein. In 169 patients (49.0 %), the thrombus spread to the retrohepatic inferior vena cava (IVC), while in 176 patients (51.0 %), it spread above the diaphragm (to the intrapericardial IVC in 59 patients (17.1 %) and to the right heart cameras in 117 patients (33.9 %)). Regional metastases were found in 90 individuals (26.1 %), while distant metastases were observed in 124 patients (35.9 %). All patients underwent surgical treatment (radical in 251 patients (72.8 %) and cytoreductive — in 94patients (27.2 %)); the technique of vascular control and circulatory support was chosen individually. In 97 patients (28.1 %), the control over the cranial thrombus boarder did not require opening of the chest cavity; eleven patients (3.2 %) were operated on with cardiopulmonary bypass.Results. The median surgery time was 215 minutes; the median blood loss was 4500 mL. Intraoperative complications were registered in 209 patients (60.6 %) and postoperative complications were observed in 118 patients (35.1 %) (including those of grade I—II in 43 individuals (12.8 %) and grade III—V in 75 individual (22.3 %)). The in-hospital mortality rate was 10.7 % (37/345). At a median follow-up of 32.3 months, overall and diseasespecific survival rates among all patients were 51.9 % and 68.3 %, respectively; relapse-free survival rate in 226patients who have undergone radical surgeries and discharged from the hospital was 61.5 %; progression-free survival rate in 82 patients who have undergone cytoreductive surgery was 33.0 %. The method ofIVC control and circulatory support had no effect on both short-term and long-term treatment outcomes (p >0.05 for both).Conclusion. The use of minimally invasive techniques of vascular control and avoidance of cardiopulmonary bypass in carefully selected RCC patients with extensive tumor venous thrombosis do not worsen the outcomes of nephrectomy and thrombectomy.
PRIAPOS trial: new conception of pathogenesis of post-brahytherapy erectile dysfunction
Authors: Novikov R. V. , Ponomareva O. I. , Novikov S. N. 
Published: May 2021

Objective: to study the anatomical-topographical relationship between the prostate gland (PG) and the vascular structures responsible for erection, to justify the new concept of erectile dysfunction pathogenesis after brachytherapy of prostate cancer (PCa).Materials and methods. The study included 66 patients with verified or suspected PCa. All patients performed magnetic resonance imaging 1.5 T in accordance with the established protocol (hybrid method of visualization of internal pudendal arteries (IPA)). 16 patients simultaneously performed computed tomography on a topometric tomography. The resulting images were analyzed using the Eclipse 4.0 (Varian Medical System, USA) system, which provides 3D models of PG, pelvic bones and critical structures of interest: IPA, cavernous crura and penile bulb.Results. The average volume of PG was 44.9 ± 18.7 (14.4—98.0) cm3. The width of penile bulb was 1.83 ± 0.38 (1.1—2.93) cm. According to the implantation technique of in brachytherapy, the damage to penile bulb can be observed in less than a fifth of patients — 18.5 % of cases.Analysis of the 3D models showed that the overlay of the distal third of the IPA on the predominantly anterior and, in part, lateral aspects of the PG was noted in 58 (87.9 %) of 66 observations. The average value of PG in a group with no interference was 25.7 ± 3.9 (18.2—29.9) cm3, with its presence — 47.6 ± 18.4 (14.4—98.0) cm3. The average length of the IPA, coinciding with the projection of the PG on the right and left is virtually no different (p >0.05) and is about 2.5 cm, and the maximum remote point of this combination lies in relation to the outer contour of the gland within 1 cm. The correlation analysis showed a strong direct correlation between the volume of PG with all the parameters of mutual spatial anatomy of the prostate and IPA (R = 0.63—0.71; p <0.0001).Conclusion. The anatomical-topographical relationship between PG and critical structures, among which the IPA plays a special role, points to the likely predominantly traumatic genesis of erectile dysfunction after PCa brachytherapy, as well as a number of other invasive procedures performed by perineal access (saturation biopsy).