bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergency rollout and conversion procedures during the three-arm robotic open-thoracotomy-view approach
Authors: Sakakura Noriaki , Nakada Takeo , Shirai Suguru , Takahara Hirotomo , Suzuki Ayumi , Takahashi Yusuke , Kuroda Hiroaki 
Published: November 2021

Abstract

OBJECTIVES
To conduct robotic lung resections (RLRs) with views similar to those in open-thoracotomy surgery (OTS), we adopted a vertical port placement and confronting upside-down monitor setting: the robotic open-thoracotomy-view approach (OTVA). We herein discuss the procedures for emergency rollout and conversion from the robotic OTVA to OTS or video-assisted thoracoscopic surgery (VATS).

METHODS
We retrospectively reviewed the cases of 88 patients who underwent RLR with three-arm OTVA using the da Vinci Xi Surgical System between February 2019 and July 2021. Robotic ports were vertically placed along the axillary line, and 2 confronting monitors and 2 assistants were positioned on each side of the patient. Three possible conversions were prepared: (i) emergency thoracotomy using an incision along the ribs in a critical situation, (ii) cool conversion using vertical incision thoracotomy in a calmer condition and (iii) conversion to confronting VATS. All staff involved in the surgery repeatedly rehearsed the emergency rollout in practice.

RESULTS
No emergent or cool conversion to OTS occurred. Two patients (2.3%) experienced confronting VATS conversions. One patient underwent an urgent conversion for a moderate haemorrhage from a pulmonary artery branch during left upper lobectomy in the introduction phase. Another patient underwent a calmer conversion during an extended RS6 + S10a segmentectomy, where staples could not be inserted appropriately due to lung lacerations. In all patients, postoperative courses were uneventful.

CONCLUSIONS
The OTVA setting is a possible option for RLRs. This report describes the emergent rollout and subsequent conversion procedures for this method.
Effects of the Partial M1 Muscarinic Cholinergic Receptor Agonist CDD-0102A on Stereotyped Motor Behaviors and Reversal Learning in the BTBR Mouse Model of Autism
Authors: Athnaiel Onella , Job Greeshma A , Ocampo Roberto , Teneqexhi Pamela , Messer William S , Ragozzino Michael E 
Published: November 2021

AbstractBackgroundAutism spectrum disorders (ASD) are a set of neurodevelopmental disorders marked by a lack of social interaction, restrictive interests, and repetitive behaviors. There is a paucity of pharmacological treatments to reduce core ASD symptoms. Various lines of evidence indicate that reduced brain muscarinic cholinergic receptor activity may contribute to an ASD phenotype.MethodsThe present experiments examined whether the partial M1 muscarinic receptor agonist, 5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine hydrochloride (CDD-0102A), alleviates behavioral flexibility deficits and/or stereotyped motor behaviors in the BTBR mouse model of autism. Behavioral flexibility was tested using a reversal learning test. Stereotyped motor behaviors were measured by eliciting digging behavior after removal of nesting material in a home cage and by measuring repetitive grooming.ResultsCDD-0102A (0.2 and 0.6 mg/kg but not 1.2 mg/kg) injected prior to reversal learning attenuated a deficit in BTBR mice but did not affect performance in B6 mice. Acute CDD-0102A treatment (1.2 and 3 mg/kg) reduced self-grooming in BTBR mice and reduced digging behavior in B6 and BTBR mice. The M1 muscarinic receptor antagonist VU0255035 (3 mg/kg) blocked the effect of CDD-0102A on grooming behavior. Chronic treatment with CDD-0102A (1.2 mg/kg) attenuated self-grooming and digging behavior in BTBR mice. Direct CDD-0102A infusions (1 µg) into the dorsal striatum reduced elevated digging behavior in BTBR mice. In contrast, CDD-0102A injections in the frontal cortex were not effective.ConclusionsThe results suggest that treatment with a partial M1 muscarinic receptor agonist may reduce repetitive behaviors and restricted interests in autism in part by stimulating striatal M1 muscarinic receptors.
A Non-Hyperelliptic Curve with Torsion Ceresa Cycle Modulo Algebraic Equivalence
Authors: Beauville Arnaud , Schoen Chad 
Published: November 2021

AbstractWe exhibit a non-hyperelliptic curve $C$ of genus $3$ such that the class of the Ceresa cycle $[C]-[C^-]$ in $JC$ modulo algebraic equivalence is torsion.
Ixodes scapularis (Ixodida: Ixodidae) Parasitizing an Unlikely Host: Big Brown Bats, Eptesicus fuscus (Chiroptera: Vespertilionidae), in New York State, USA
Authors: Occi James L , Campbell Victoria M , Fonseca Dina M , Robbins Richard G 
Published: November 2021

Abstract
Ixodes scapularis Say is a three-host tick that has been recorded feeding on over 150 different species of terrestrial vertebrates (mammals, birds, and reptiles). This tick is found throughout the northeastern, coastal southeastern, and upper midwestern United States and is considered the most significant vector of tick-borne pathogens to humans in North America. Despite its ubiquity and broad host range, I. scapularis previously has not been reported feeding on bats (Chiroptera). However, during 2019 and 2020, larvae and nymphs of I. scapularis were recovered from big brown bats, Eptesicus fuscus (Palisot de Beauvois), at four locations in rural New York State, USA. All Ixodes infested bats were injured and found on the ground; therefore, parasitism by I. scapularis was likely opportunistic. Nonetheless, the large number of pathogens known to be associated with bats and the frequency with which I. scapularis bites people suggest that this host–tick relationship is of at least potential epidemiological significance.
Ranger O Low Titer (ROLO): Whole Blood Transfusion for Forward Deployed Units
Authors: Song Kaoru H , Winebrenner Hans M , Able Ty E , Bowen Charles B , Dunn Noel A , Shevchik Joseph D 
Published: November 2021

ABSTRACT
First-time use of Ranger O Low Titer (ROLO) blood and implementation of a forward-walking blood bank using predetermined donors proved essential in the survival of a 33-year-old active duty soldier following a complex blast injury during combat operations. The patient sustained significant bone, soft tissue, and vascular damage and continued to deteriorate despite resuscitation with cold-stored whole blood (WB). Only after utilizing the ROLO battle drill and transfusing with fresh WB was the patient able to be stabilized and evacuated. In this case report, we discuss how ROLO walking blood bank takes the next step in aiding resuscitation, providing smaller, forward-deployed units with blood resupply without the administrative burden of storage, particularly in resource-scarce environments. We provide an overview of WB and contrast its use to that of component therapy. In conjunction with the Golden Hour, ROLO can be incorporated as the standard damage control resuscitation to reduce the risks of noncompressible hemorrhage. By taking precautionary steps in the pre-deployment setting, ROLO offers an invaluable alternative to conventional resuscitation.
Immunophenotyping comparison of inflammatory cells betweenMalasseziafolliculitis and pityriasis versicolor lesions
Authors: Chen Yu , Yang Yan-Ping , Qiu Fang , Wang Yu-Jie , Fan Yi-Ming 
Published: November 2021

AbstractImmunophenotyping of inflammatory dermal infiltrates in Malassezia folliculitis (MF) and pityriasis versicolor (PV) lesions is less reported. Immunohistochemistry was performed on 21 MF lesions, 10 PV lesions, and 10 control skin. CD3+, CD4+, CD8+, CD20+, CD68+, and CD117+ cells were increased in MF compared with PV and normal skin (P &lt; 0.01–0.05), while CD3+, CD4+, and CD20+ cells were higher in PV than in normal skin (P &lt; 0.05). Dermal CD1a+ cells were higher only in PV (P &lt; 0.05). Although both cellular and humoral immune responses are involved in pathogenesis of MF and PV, their difference may contribute to clinicopathological discrepancy between two disorders.Lay SummaryMalassezia folliculitis and pityriasis versicolor are common Malassezia-induced superficial mycoses. Their clinicopathological discrepancy may be due to the difference of cellular and humoral immune responses.
In vitro activity of eight antifungal drugs against Chaetomiaceae
Authors: Dolatabadi Somayeh , Najafzadeh Mohammad Javad , Houbraken Jos , Vicente Vania , de Hoog Sybren , Meis Jacques F 
Published: November 2021

Abstract

The incidence of infections caused by uncommon Chaetomiaceae (Chaetomium and related species) in humans has increased in the recent years. The in vitro activity of eight antifungal drugs (amphotericin B, five azoles, two echinocandins) against 42 morphologically identified Chaetomium strains was determined according to the Clinical and Laboratory Standards Institute (CLSI) guideline. The strains were subsequently identified based on sequences of the internal transcribed spacer 1 and 2 including the intervening 5.8S nrDNA region (ITS) and the partial β tubulin gene (tub2). Chaetomium globosum (n = 24), was the most frequently isolated species, followed by Amesia atrobrunnea (syn. Chaetomium atrobrunnea, n = 6), Dichotomopilus dolichotrichus (syn. Chaetomium dolichotrichum, n = 2) and Acrophialophora jodhpurensis, Chaetomium coarctatum, C. elatum, C. gracile, C. subaffine, C. tarraconense, C. unguicola, Dichotomopilus sp., Dichotomopilus variostiolatus, Ovatospora brasiliensis (all represented by a single strain). The geometric means of the minimum inhibitory concentrations/minimum effective concentrations (MICs/MECs) of the antifungals across all strains were (in increasing order): micafungin 0.12 µg/ml, itraconazole and posaconazole 0.21 µg/ml, amphotericin B 0.25 µg/ml, voriconazole 0.45 µg/ml, isavuconazole 0.54 µg/ml, caspofungin 2.57 µg/ml, and fluconazole 45.25 µg/ml. Micafungin had the lowest geometric mean followed by amphotericin B which had the largest range against tested isolates. All examined C. globosum strains had similar antifungal susceptibility patterns. Fluconazole and caspofungin could not be considered as an option for treatment of infections caused by Chaetomium and chaetomium-like species.

Lay summary
Infections caused by uncommon fungi such as Chaetomium have increased in the recent years. Chaetomium globosum has been reported from onychomycosis and phaeohyphomycosis. This species often induces superficial infections in immunocompetent patients. The taxonomy of Chaetomium spp. has changed dramatically in the last years. Antifungal treatment is a crucial step for managing these kinds of infections. Therefore, the in vitro activity of eight antifungal drugs against Chaetomium strains was determined and β-tubulin (tub2) sequencing was applied to identify the strains. Chaetomium globosum was the most frequent species in our dataset. Based on the results of susceptibility testing, micafungin had the lowest geometric mean followed by amphotericin B. Fluconazole and caspofungin cannot be considered a proper treatment option for infections caused by Chaetomium and chaetomium-like species.
C60 cation as the carrier of the λ 9577 Å and λ 9632 Å diffuse interstellar bands: further support from the VLT/X-Shooter spectra
Authors: Nie T P , Xiang F Y , Li Aigen 
Published: November 2021

ABSTRACT
Ever since they were first detected over 100 yr ago, the mysterious diffuse interstellar bands (DIBs), a set of several hundred broad absorption features seen against distant stars in the optical and near-infrared wavelength range, largely remain unidentified. The close match, both in wavelengths and in relative strengths, recently found between the experimental absorption spectra of gas-phase buckminsterfullerene ions (C$_{60}^{+}$) and four DIBs at $\lambda 9632\, {\rm \mathring{\rm A}}$, $\lambda 9577\, {\rm \mathring{\rm A}}$, $\lambda 9428\, {\rm \mathring{\rm A}}$ and $\lambda 9365\, {\rm \mathring{\rm A}}$ (and, to a lesser degree, a weaker DIB at $\lambda 9348\, {\rm \mathring{\rm A}}$) suggests that C$_{60}^{+}$ is a promising carrier for these DIBs. However, arguments against the C$_{60}^{+}$ identification remain and are mostly concerned with the large variation in the intensity ratios of the $\lambda 9632\, {\rm \mathring{\rm A}}$ and $\lambda 9577\, {\rm \mathring{\rm A}}$ DIBs. In this work, we search for these DIBs in the X-shooter archival data of the European Southern Observatory’s Very Large Telescope, and we identify the $\lambda 9632\, {\rm \mathring{\rm A}}$, $\lambda 9577\, {\rm \mathring{\rm A}}$, $\lambda 9428\, {\rm \mathring{\rm A}}$ and $\lambda 9365\, {\rm \mathring{\rm A}}$ DIBs in a sample of 25 stars. While the $\lambda 9428\, {\rm \mathring{\rm A}}$ and $\lambda 9365\, {\rm \mathring{\rm A}}$ DIBs are too noisy to allow any reliable analysis, the $\lambda 9632\, {\rm \mathring{\rm A}}$ and $\lambda 9577\, {\rm \mathring{\rm A}}$ DIBs are unambiguously detected and, after correcting for telluric water vapour absorption, their correlation can be used to probe their origin. To this end, we select a subsample of nine hot, O- or B0-type stars of which the stellar Mg ii contamination to the $\lambda 9632\, {\rm \mathring{\rm A}}$ DIB is negligibly small. We find that their equivalent widths, after being normalized by reddening to eliminate their common correlation with the density of interstellar clouds, exhibit a tight, positive correlation, supporting C$_{60}^{+}$ as the carrier of the $\lambda 9632\, {\rm \mathring{\rm A}}$ and $\lambda 9577\, {\rm \mathring{\rm A}}$ DIBs.
Agriculture after Brexit
Authors: Helm Dieter 
Published: November 2021

Abstract:
Brexit repatriates agriculture policy and subsidies after over 40 years of determination by the European Commission. The paper starts by describing the baseline at Brexit, noting the relatively small economic contribution, the problems of competitiveness given the UK’s geology and geography, and the poor environmental outcomes. The scope for improvement is correspondingly large, and in particular through the impacts of the new agricultural policy based upon public money for public goods and for England, the Environmental Land Management Schemes. Larger and more long-term impacts will come through new trade agreements, through new technologies, including digitalization, robotics, and genetics, and through carbon farming and offsets. Finally, the paper sets out a framework for a future assessment of the impact of Brexit.
P010 Clinico-epidemiological characteristics and outcomes of Juvenile Idiopathic Arthritis (JIA) patients in Kenya: data from the KAPRI registry
Authors: Migowa A , Odhiambo R , Orwa J , Shah J 
Published: November 2021

Abstract

Background
Pediatric rheumatic diseases pose a significant disease burden upon children and their families (1–3). They lead to physical disability and diminished quality of life (1–3). Determination of the burden and clinical characteristics of these diseases is a critical first step to improving access to care and optimizing use of existing health systems for the well-being of these patients (4). This is in line with the goal of the Bone and Joint decade (2000–2010) aimed at increasing recognition and understanding of the impact of musculoskeletal diseases (5,6). The Kenya Pediatric Rheumatology Registry (KAPRI) offers a unique opportunity to pioneer and spearhead a systematic and organized format to inform policy and better healthcare provision. Our objective was to determine the patient characteristics, clinical features and outcomes of Juvenile Idiopathic Arthritis (JIA) patients assessed at the Aga Khan University Medical College East Africa from March 2019 to December 2020.

Methods
Data of JIA patients on age, gender, laboratory and clinical features at diagnosis and treatment options offered were extracted from the database. A further detailed chart review was undertaken to determine the proportion of patients who achieved remission or minimally active diseases.

Results
Among the 207 patients enrolled thus far, 16 (7.7%) were diagnosed to have JIA. Majority of the patients were females (75%; n = 12) with a mean age of 7 years and 3 months (Range : 1 year—13 years 7 months).
All patients had joint pain and swelling as the initial presenting complaints. Majority of the patients had polyarticular JIA (75%, n = 12). The other 4 patients were oligoarticular (n = 2) and systemic JIA (n = 2). Among the polyarticular JIA patients (n = 12), only 3 (25%) were rheumatoid factor (RF) positive and 1 was antinuclear antibody (ANA) positive. The oligoarticular and systemic JIA patients were all negative for antinuclear antibody, rheumatoid factor and cyclic citrullinated peptide antibodies (anti-ccp). Seven patients (43.8%) required biological therapies; tocilizumab (n = 2: systemic JIA), adalimumab (n = 2: polyarticular JIA), etanercept (n = 2: polyarticular JIA) andtofacitnib (n = 1: polyarticular JIA). One patient with systemic JIA on tocilizumab developed herpes simplex which was successfully managed with oral acyclovir. All the other patients did not develop any infections, allergic reactions or any other untoward events as adverse outcomes following the use of biological therapies. Five patients have attained remission as illustrated in the table below. Two patients have been lost to follow up.

Conclusion
Seronegative polyarticular JIA was the predominant form of JIA observed with a predilection to affect more girls and boys. Over a period of 2 years, remission has been attained among 31.25% of the patients (5 of 16) with use of synthetic disease modifying anti-rheumatic drugs and biological therapies.
P024 Efficacy and tolerance of methotrexate in patients with Juvenile Idiopathic Arthritis
Authors: Fazaa A , Rouatbi F , Miladi S , Ouenniche K , Souabni L , Kassab S , Chekili S , Ben Abdelghani K , Laatar A 
Published: November 2021

Abstract

Background
Juvenile idiopathic arthritis (JIA) is the most common inflammatory rheumatic disease for children. The therapeutic management depends on several factors and is based on different treatments including methotrexate (MTX). The aim of our study was to determine the efficacy and safety of MTX in JIA.

Methods
This is a monocentric retrospective study of 37 patients followed for JIA according to the 2001 International League of Association of Rheumatology (ILAR) criteria and treated with MTX. Socio-demographic, clinical, paraclinical and therapeutic data were collected. Disease activity was assessed by the JADAS score. Highly active JIA was defined as JADAS superior to 25.

Results
There were 25 boys (67.5%) and 12 girls (32.4%) with a median age of 6.3 years [4–13]. The average duration of the rheumatic disease was 2.7 years [2.5–5.3]. The type of JIA was: oligoarticular in 22 cases (59.4%), polyarticular in 10 cases (27%), arthritis related to enthesitis in 3 cases (8.1%) and systemic in 2 cases (5.4%). Twenty patients (54%) received oral corticosteroid therapy for a mean period of 1.7 years [0.6–3] with a mean daily dose of 10 mg/day of prednisone or equivalent.
Oral MTX was prescribed to all patients with a mean weekly dose of 10 mg/m2 body surface [10–15]. MTX was initiated after a mean period of 6.2 months [3.1–11.4] from diagnosis. The mean treatment duration was 50 months [34–66].
Observance of MTX was 80.5%. Remission with MTX was achieved in 28 patients (75.6%) after a mean treatment duration of 7.5 months [5–11], with a mean JADAS of 5.1 [3.5–10].
Despite good observance of MTX, eight patients (21.6%) continued to have high disease activity with a mean JADAS score of 32 [25–40].
Tolerance to oral MTX was good, with side effects occurring only with 5 patients (13.5%), such as epigastralgia in 2 cases (which disappeared after switching to the intramuscular administration), a skin reaction in one case, and hepatic cytolysis reversible when stopping the treatment in 2 other cases.

Conclusion
MTX still has a place in the therapeutic management of JIA and appears to be a well-tolerated and effective treatment.
P037 Does perinatal history and delivery enhance the risk of hip involvement in Juvenile Idiopathic Arthritis patients? A case-control study
Authors: Yasmine Makhlouf , Ferjani Hanene , Hassen Affes , Maatallah Kaouther , Ben Nessib Dorra , Triki Wafa , Kaffel Dhia , Mourad Jenzri , Hamdi Wafa 
Published: November 2021

Abstract

Background
Children are vulnerable to congenital and developmental hip disorders. One of the causes of coxitis among children is juvenile idiopathic arthritis (JIA). Existing data on associations between maternal and early childhood exposures highlighted the potential role of prematurity in JIA [1]. The aim of this study was to compare perinatal history in JIA children with coxitis compared with patients with other causes of hip involvement.

Methods
We conducted a cross-sectional study including children with JIA complicated with coxitis and patients with other causes of hip involvement. We recorded sociodemographic data and the hip disorder. The mode of delivery, the values of the neonatal birth weight as well as the delivery method (vaginal, cesarean (C) section) were retrieved from medical records. We divided the patients into two groups: G1: JIA patients with coxitis and G2: patients with other causes of hip involvement. We compared delivery mode, as well as perinatal outcomes between the two groups.

Results
The study included 81 patients. There was a male predominance (59.3% males vs 40.7% females) with a sex-ratio of 1.45. The mean age of diagnosis was 9.9 years [1–16]. The mean disease duration was 9 months [0.1–156]. Hip disorders were distributed as follows: Legg-Calvé-Perthes disease (n = 3), epiphysiolysis of the femur head (n = 30), transient synovitis of the hip n = 7, septic hip (n = 10), tumor (n = 4), hip dislocation (n = 8), hip dysplasia (n = 4), juvenile idiopathic arthritis with coxitis (n = 15). The mean birth weight of the children was 3.4 kg [1.3–9]. About half of the patients had a natural delivery (55.6%) and most of them a face presentation (71.6%). A twin pregnancy was reported only in 2.5% of cases. Childbirth complications were reported in 7.4% of cases: umbilical cord prolapse (n = 1), Meconium aspiration syndrome (n = 1), failure to descend (n = 1), acute fetal distress (n = 3). Most of them had a normal growth and psychomotor development (96% and 97% respectively). There was no statistical difference between the two groups regarding delivery mode and fetal presentation before birth (P = 0.07, P = 0.48 respectively). Similarly, weight at birth was similar between JIA children and patients with other hip involvement (P = 0.52).

Conclusion
Our study showed that maternal and perinatal history did not differ between JIA patients with coxitis and patients with other causes of hip involvement.