bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurse co-ordinated health and lifestyle modification for reducing multiple cardio-metabolic risk factors in regional adults: outcomes from the MODERN randomized controlled trial
Authors: Carrington Melinda J , Zimmet Paul Z 
Published: April 2021

Abstract

Background
Nurse-led health and lifestyle modification programmes can prevent cardio-metabolic diseases and be advantageous where health disparities exist.

Aims
To assess the effectiveness of a nurse-driven health and lifestyle modification programme in improving cardio-metabolic risk parameters for higher-risk regional residing adults.

Methods
We conducted an open, parallel-group randomized controlled trial in two sites. Participants were aged 40–70 years with no prior cardiovascular disease who had any three or more of; central obesity, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure (BP) and dysglycaemia. Intervention participants received individual face-to-face and telephone coaching for improving cardio-metabolic risk. Control group participants received standard care and general information about risk factor management. The primary endpoint was the percentage of participants who achieved the target risk factor thresholds or clinically significant minimum changes for any three or more cardio-metabolic risk factors during 24 months of follow-up.

Results
Participant average age was 57.6 (SD 7.6) years, 61% were female and 71% were employed. The primary endpoint was achieved by 76% intervention (97 of 127) and 71% usual care (92 of 129) participants [adjusted risk ratio (RR): 1.08; 95% CI 0.94, 1.24; P = 0.298]. Improved BP in the intervention group was more likely than in the control group (84% vs. 65%) (adj. RR: 1.28; 95% CI 1.11, 1.48; P = 0.001) but no other cardio-metabolic component.

Conclusion
Nurse intervention to modify cardio-metabolic risk parameters had no enhanced effectiveness compared with usual care. However, participation was associated with improvements in cardio-metabolic abnormalities, with particular emphasis on BP.

Trial Registration
Registered with the Australian New Zealand Clinical Trial Registry (ACTRN12616000229471).
INTERCONVERSION OF YEAST MATING TYPES III. ACTION OF THE HOMOTHALLISM (HO) GENE IN CELLS HOMOZYGOUS FOR THE MATING TYPE LOCUS
Authors: Hicks James B , Strathern Jeffrey N , Herskowitz Ira 
Published: April 2021

ABSTRACT
Mating type interconversion in homothallic Saccharomyces cerevisiae has been studied in diploids homozygous for the mating type locus produced by sporulation of a/a/a/α and a/a/α/α tetraploid strains. Mating type switches have been analyzed by techniques including direct observation of cells for changes in α-factor sensitivity. Another method of following mating type switching exploits the observation that a/α cells exhibit polar budding and a/a and α/α cells exhibit medial budding.—These studies indicate the following: (1) The allele conferring the homothallic life cycle (HO) is dominant to the allele conferring the heterothallic life cycle (ho). (2) The action of the HO gene is controlled by the mating type locus—active in a/a and α/α cells but not in a/α cells. (3) The HO (or HO-controlled) gene product can act independently on two mating type alleles located on separate chromosomes in the same nucleus. (4) A switch in mating type is observed in pairs of cells, each of which has the same change.
THE EFFECT OF COMBINING ALLELES INTO ELECTROPHORETIC CLASSES ON DETECTING LINKAGE DISEQUILIBRIUM
Authors: Zouros E , Golding G B , MacKay Trudy F C 
Published: April 2021

ABSTRACT
When alleles are combined into few detectable classes, linkage correlations are underestimated most of the time. The probability that the linkage correlation will be underestimated is a function of the actual degree of correlation and the evenness of the allelic distribution, but is mainly determined by the distribution of alleles into distinguishable classes. With only two alleles per class this probability will usually be higher than 0.7. Also, the consistency in the sign of the linkage disequilibrium over many populations may escape detection. An increase of sample size by one order of magnitude or more may be required to compensate for the loss in detection power. It follows that the available electrophoretic studies of linkage correlations, although negative in their majority, do not suggest that epistatic interactions and linkage disequilibria are rare in natural populations.
NON-MENDELIAN FEMALE STERILITY IN DROSOPHILA MELANOGASTER: INFLUENCE OF AGING AND THERMIC TREATMENTS. III. CUMULATIVE EFFECTS INDUCED BY THESE FACTORS
Authors: Bucheton Alain 
Published: April 2021

ABSTRACT
Crosses between various strains of Drosophila melanogaster may give rise to a female sterility of non-Mendelian determination. Reduced fertility is observed in females, known as SF females, bred from crosses between females of "reactive" strains and males of "inducer" strains. The reduced fertility of the SF females is the result of an interaction between an extrachromosomal property, the reactivity, and a chromosomal factor, I. The extrachromosomal property varies considerably in its ability to reduce fertility. The fer-tility reduction of the SF females corresponds to what is known as the reactivity level of their reactive mothers. Two nongenetic factors can modify the level of reactivity: aging and temperature. The action of aging is cumulative. When the flies of a reactive strain are submitted at each generation to the action of this factor, the level of reactivity of this strain is gradually modified. The modifications induced are reversible. Indeed, when such a modified strain is returned to standard breeding conditions, the reactivity returns progressively to its initial level. The effect of thermic treatments also seems to be cumulative and reversible.
GENETIC ANALYSIS OF THE ANTENNAPEDIA GENE COMPLEX (ANT-C) AND ADJACENT CHROMOSOMAL REGIONS OF DROSOPHILA MELANOGASTER. II. POLYTENE CHROMOSOME SEGMENTS 84A–84B1,2
Authors: Lewis R A , Wakimoto B T , Denell R E , Kaufman T C 
Published: April 2021

ABSTRACT
The existence of a gene complex in the proximal right arm of chromosome 3 of Drosophila melanogaster involved in the development of the head and thorax was originally suggested by the phenotypes of several dominant homoeotic mutations and their revertants. A screen for mutations utilizing Df(3R) AntpNS+R17 (proximally broken in salivary region 84B1,2) yielded, among 102 recovered mutations, 17 localized by deficiency mapping to the putative homoeotic cluster. These fell into four complementation groups, two of which were characterized by homoeotic phenotypes. To explore the limits of the Antennapedia gene complex (ANT-C) more proximally, a second screen has been undertaken utilizing Df(3R)Scr, a deficiency of 84A1-B1,2.——Of 2832 chromosomes screened, 21 bearing alterations localized to polytene interval 84A-84B1,2 have been recovered. Sixteen are recessive lethals, and five showing reduced viability display a visible phenotype in surviving individuals. Complementation and phenotypic analyses revealed four complementation groups proximal to those identified in the previous screen, including two new alleles of the recessive homoeotic mutation, proboscipedia (pb). Ten of the new mutations correspond to complementation groups defined previously in the Df(3R)AntpNS+R17 screen, four to the EbR11 group, two to the Scr group and four to the Antp group.——On the basis of the phenotypes of the 39 mutations localized to this region, plus their interactions with extant homoeotic mutations, we postulate that there are at least five functional sites comprising the ANT-C. Three have been demonstrated to he homoeotic in nature. The specific homoeotic transformations thus far observed suggest that these loci are critical for normal development of adult labial, maxillary and thoracic structures.
SOMATIC EXPRESSION AND AUTOSOMAL INHERITANCE OF PHOSPHOGLYCERATE KINASE B IN KANGAROOS
Authors: Vandeberg J L , Cooper D W , Sharman G B , Poole W E 
Published: April 2021

ABSTRACT
The PGK-B isozyme, currently known as PGK-2 in the mouse nomenclature, is the predominant PGK isozyme in mammalian sperm. In many species it is detectable only in sperm, in spermatogenic testes and in epididymides containing sperm. In this paper, we provide evidence that some kangaroo species express low PGK-B activity in somatic tissues, in addition to high activity in testes. Three kangaroo species, M. rufogrzseus, M. robustus and M. giganteus, exhibit polymorphism of PGK-B. Breeding data support the hypothesis of autosomal co-dominant inheritance, as is the case in mice. Population data for the three polymorphisms are discussed. PGK-B is not detectable in somatic tissues or spermatogenic testis extracts of monotreme mammals, birds or lizards; it is probably restricted to therian mammals.
Earthquake magnitude and location estimation from real time seismic waveforms with a transformer network
Authors: Münchmeyer Jannes , Bindi Dino , Leser Ulf , Tilmann Frederik 
Published: April 2021

SUMMARY
Precise real time estimates of earthquake magnitude and location are essential for early warning and rapid response. While recently multiple deep learning approaches for fast assessment of earthquakes have been proposed, they usually rely on either seismic records from a single station or from a fixed set of seismic stations. Here we introduce a new model for real-time magnitude and location estimation using the attention based transformer networks. Our approach incorporates waveforms from a dynamically varying set of stations and outperforms deep learning baselines in both magnitude and location estimation performance. Furthermore, it outperforms a classical magnitude estimation algorithm considerably and shows promising performance in comparison to a classical localization algorithm. Our model is applicable to real-time prediction and provides realistic uncertainty estimates based on probabilistic inference. In this work, we furthermore conduct a comprehensive study of the requirements on training data, the training procedures and the typical failure modes. Using three diverse and large scale data sets, we conduct targeted experiments and a qualitative error analysis. Our analysis gives several key insights. First, we can precisely pinpoint the effect of large training data; for example, a four times larger training set reduces average errors for both magnitude and location prediction by more than half, and reduces the required time for real time assessment by a factor of four. Secondly, the basic model systematically underestimates large magnitude events. This issue can be mitigated, and in some cases completely resolved, by incorporating events from other regions into the training through transfer learning. Thirdly, location estimation is highly precise in areas with sufficient training data, but is strongly degraded for events outside the training distribution, sometimes producing massive outliers. Our analysis suggests that these characteristics are not only present for our model, but for most deep learning models for fast assessment published so far. They result from the black box modeling and their mitigation will likely require imposing physics derived constraints on the neural network. These characteristics need to be taken into consideration for practical applications.
The devil is in the detail: reflections on the value and application of cognitive interviewing to strengthen quantitative surveys in global health
Authors: Scott K , Ummer O , LeFevre A E 
Published: April 2021

Abstract
Cognitive interviewing is a qualitative research method for improving the validity of quantitative surveys, which has been underused by academic researchers and monitoring and evaluation teams in global health. Draft survey questions are administered to participants drawn from the same population as the respondent group for the survey itself. The interviewer facilitates a detailed discussion with the participant to assess how the participant interpreted each question and how they formulated their response. Draft survey questions are revised and undergo additional rounds of cognitive interviewing until they achieve high comprehension and cognitive match between the research team’s intent and the target population’s interpretation. This methodology is particularly important in global health when surveys involve translation or are developed by researchers who differ from the population being surveyed in terms of socio-demographic characteristics, worldview, or other aspects of identity. Without cognitive interviewing, surveys risk measurement error by including questions that respondents find incomprehensible, that respondents are unable to accurately answer, or that respondents interpret in unintended ways. This methodological musing seeks to encourage a wider uptake of cognitive interviewing in global public health research, provide practical guidance on its application, and prompt discussion on its value and practice. To this end, we define cognitive interviewing, discuss how cognitive interviewing compares to other forms of survey tool development and validation, and present practical steps for its application. These steps cover defining the scope of cognitive interviews, selecting and training researchers to conduct cognitive interviews, sampling participants, collecting data, debriefing, analysing the emerging findings, and ultimately generating revised, validated survey questions. We close by presenting recommendations to ensure quality in cognitive interviewing.
The rotation of selected globular clusters and the differential rotation of M3 in multiple populations from the SDSS-IV APOGEE-2 survey
Authors: Szigeti László , Mészáros Szabolcs , Szabó Gyula M , Fernández-Trincado José G , Lane Richard R , Cohen Roger E 
Published: April 2021

ABSTRACT
In this paper, we analyse 10 globular clusters in order to measure their rotational properties by using high precision radial velocity data from the SDSS-IV APOGEE-2 survey. Out of the 10 clusters we were able to successfully measure the rotation speed and position angle of the rotation axis for 9 clusters (M2, M3, M5, M12, M13, M15, M53, M92, M107). The comparison between our results and previous ones shows a really good agreement within our uncertainties. For four of the globular clusters, M3, M13, M5, and M15, we separated the sample into two generation of stars using their [Al/Fe] abundances and examined the kinematic features of these generations separately from one another. In case of M3, we found significant difference between the rotational properties of first and second populations, confirming for the first time the predictions of several numerical simulations from the literature. The other three clusters (M5, M13, M15) also show smaller deviation between the two groups of stars, but those deviations are comparable to our errors.
The double-peaked Type Ic supernova 2019cad: another SN 2005bf-like object
Authors: Gutiérrez C P , Bersten M C , Orellana M , Pastorello A , Ertini K , Folatelli G , Pignata G , Anderson J P , Smartt S , Sullivan M , Pursiainen M , Inserra C , Elias-Rosa N , Fraser M , Kankare E , Moran S , Reguitti A , Reynolds T M , Stritzinger M , Burke J , Frohmaier C , Galbany L , Hiramatsu D , Howell D A , Kuncarayakti H , Mattila S , Müller-Bravo T , Pellegrino C , Smith M 
Published: April 2021

ABSTRACT
We present the photometric and spectroscopic evolution of supernova (SN) 2019cad during the first ∼100 d from explosion. Based on the light-curve morphology, we find that SN 2019cad resembles the double-peaked Type Ib/c SN 2005bf and the Type Ic PTF11mnb. Unlike those two objects, SN 2019cad also shows the initial peak in the redder bands. Inspection of the g-band light curve indicates the initial peak is reached in ∼8 d, while the r-band peak occurred ∼15 d post-explosion. A second and more prominent peak is reached in all bands at ∼45 d past explosion, followed by a fast decline from ∼60 d. During the first 30 d, the spectra of SN 2019cad show the typical features of a Type Ic SN, however, after 40 d, a blue continuum with prominent lines of Si ii λ6355 and C ii λ6580 is observed again. Comparing the bolometric light curve to hydrodynamical models, we find that SN 2019cad is consistent with a pre-SN mass of 11 M⊙, and an explosion energy of 3.5 × 1051 erg. The light-curve morphology can be reproduced either by a double-peaked 56Ni distribution with an external component of 0.041 M⊙, and an internal component of 0.3 M⊙ or a double-peaked 56Ni distribution plus magnetar model (P ∼ 11 ms and B ∼ 26 × 1014 G). If SN 2019cad were to suffer from significant host reddening (which cannot be ruled out), the 56Ni model would require extreme values, while the magnetar model would still be feasible.
VLBI images at 327 MHz of compact steep spectrum and GHz-peaked spectrum sources from the 3C and PW samples
Authors: Dallacasa D , Orienti M , Fanti C , Fanti R 
Published: April 2021

ABSTRACT
We present results on global very long baseline interferometry (VLBI) observations at 327 MHz of 18 compact steep-spectrum (CSS) and GHz-peaked spectrum (GPS) radio sources from the 3C and the Peacock & Wall catalogues. About 80 per cent of the sources have a ‘double/triple’ structure. The radio emission at 327 MHz is dominated by steep-spectrum extended structures, while compact regions become predominant at higher frequencies. As a consequence, we could unambiguously detect the core region only in three sources, likely due to self-absorption affecting its emission at this low frequency. Despite their low surface brightness, lobes store the majority of the source energy budget, whose correct estimate is a key ingredient in tackling the radio source evolution. Low-frequency VLBI observations able to disentangle the lobe emission from that of other regions are therefore the best way to infer the energetics of these objects. Dynamical ages estimated from energy budget arguments provide values between 2 × 103 and 5 × 104 yr, in agreement with the radiative ages estimated from the fit of the integrated synchrotron spectrum, further supporting the youth of these objects. A discrepancy between radiative and dynamical ages is observed in a few sources where the integrated spectrum is dominated by hotspots. In this case the radiative age likely represents the time spent by the particles in these regions, rather than the source age.
Fingerprints of stellar populations in the near-infrared: an optimized set of spectral indices in the JHK bands 0
Authors: Eftekhari Elham , Vazdekis Alexandre , La Barbera Francesco 
Published: April 2021

ABSTRACT
Stellar population studies provide unique clues to constrain galaxy formation models. So far, detailed studies based on absorption line strengths have mainly focused on the optical spectral range although many diagnostic features are present in other spectral windows. In particular, the near-infrared (NIR) can provide a wealth of information about stars, such as evolved giants, that have less evident optical signatures. Due to significant advances in NIR instrumentation and extension of spectral libraries and stellar population synthesis (SPS) models to this domain, it is now possible to perform in-depth studies of spectral features in the NIR to a high level of precision. In this work, taking advantage of state-of-the-art SPS models covering the NIR spectral range, we introduce a new set of NIR indices constructed to be maximally sensitive to the main stellar population parameters, namely age, metallicity, and initial mass function (IMF). We fully characterize the new indices against these parameters as well as their sensitivity to individual elemental abundance variations, velocity dispersion broadening, wavelength shifts, signal-to-noise ratio, and flux calibration. We also present, for the first time, a method to ensure that the analysis of spectral indices is not affected by sky contamination, which is a major challenge when dealing with NIR spectroscopy. Moreover, we discuss two main applications: (i) the ability of some NIR spectral indices to constrain the shape of the low-mass IMF and (ii) current issues in the analysis of NIR spectral indices for future developments of SPS modelling.
A Multicenter, Double-Blind, Randomized, Placebo-Controlled Phase 2b Trial of Cytisinicline in Adult Smokers (The ORCA-1 Trial)
Authors: Nides Mitchell , Rigotti Nancy A , Benowitz Neal , Clarke Anthony , Jacobs Cindy 
Published: April 2021

Abstract

Introduction
Cytisinicline (known as cytisine), a nicotinic acetylcholine receptor partial agonist, is a smoking cessation aid currently marketed in Central and Eastern Europe using a 1.5-mg/tablet 25-day downward titration schedule. No prior studies have evaluated other doses or administration schedules. This study evaluated the effects of a higher dosage and simplified dosing schedule on drug efficacy and tolerability.

Methods
ORCA-1 was a double-blind, randomized, placebo-controlled clinical trial that provided cytisinicline or placebo tablets plus behavioral support for 25 days. Adult smokers (&gt;10 cigarettes daily) committed to quitting smoking were randomized to compare 2 cytisinicline doses (1.5 mg and 3 mg) versus placebo, and 2 administration schedules [downward titration versus 3 times daily (TID)]. Primary outcome was a reduction in expected cigarettes smoked at end of treatment; secondary outcomes were biochemically confirmed 7-day abstinence at Week 4 and continuous abstinence from Weeks 5 to 8.

Results
Among 254 participants, those in cytisinicline arms (regardless of dose or schedule) had greater reductions in cigarettes smoked versus placebo, with differences observed in 3 cytisinicline arms statistically significant versus placebo. All cytisinicline arms had statistically significantly higher abstinence rates at Week 4 versus placebo. Both cytisinicline arms using TID schedules had statistically significantly higher continuous abstinence rates from Weeks 5 to 8 compared with placebo. Participants in the cytisinicline 3-mg TID arm had the highest abstinence rate. There were no safety concerns with either 1.5-mg or 3-mg cytisinicline.

Conclusion
Based on simpler dose scheduling, excellent tolerability, and best-continued abstinence rate, cytisinicline 3-mg TID was selected for future Phase 3 studies.

Implications
Although the 1.5-mg 25-day titration schedule has been marketed in Central and Eastern Europe for decades, this study explored using a higher dosage and a simplified dosing schedule for impact on cytisinicline efficacy and tolerability. Based on these results, a Phase 3 program was initiated using cytisinicline 3-mg tablets on a TID schedule for potential market approval in the United States.
The Dollar Profits to Insider Trading
Authors: Cziraki Peter , Gider Jasmin 
Published: April 2021

Abstract
This article studies insider trading quantities and dollar profits to measure the benefits insiders extract from their superior information. Dollar profits are economically small for a typical insider, the median insider earning $464 per year. The correlation between dollar profits and percentage returns is moderate, because returns are negatively correlated with trade size and frequency. We show that these correlations vary with proxies for insider preferences, firm-level monitoring, and regulatory scrutiny. As a consequence, variables that predict percentage returns fail to predict dollar profits, and past dollar profits are negatively related to future returns. Our work suggests that dollar profits are a better measure for corporate governance applications of insider trading.