bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subsubleading soft graviton symmetry and MHV graviton scattering amplitudes
Authors: Banerjee Shamik , Ghosh Sudip , Samal Sai Satyam 
Published: August 2021

Abstract
In [8] it was shown that supertranslation and $$ \overline{\mathrm{SL}\left(2,\mathbb{C}\right)} $$

SL

2
ℂ

¯

current algebra symmetries, corresponding to leading and subleading soft graviton theorems, are enough to determine the tree level MHV graviton scattering amplitudes. In this note we clarify the role of subsubleading soft graviton theorem in this context.
Force distribution in self-tapping screws: experimental investigations with fibre Bragg grating measurement screws
Authors: Claus Timo , Seim Werner , Küllmer Johannes 
Published: August 2021

AbstractThe pull-out resistance of fully threaded, self-tapping screws under axial loading has been investigated intensively in the past. Actual design models are based mainly on empirical data because the detailed interaction between the screw thread and the surrounding timber member remains unclear and might depend on the test set-up. An innovative screw sensor with 19 internal fibre Bragg gratings (FBGs) was developed to measure the forces along the screw axis. The screw diameter was 12 mm and the maximum embedding length was 360 mm. The FBG measurement screw was applied in pull-out tests under different support conditions. The results carried out show details of the axial forces along fully threaded screws depending on the magnitude of the screw axis to grain angle, the embedding length, the material and the support conditions. Load transfer between the screw and the surrounding timber was determined by means of the change of axial forces along the screw axis. A comparison of the experimental results with Volkersen’s theory points out the decisive dependency of the support conditions on the axial forces in fully threaded self-tapping screws. Additionally, the experimental test results show indications of shear and compressive stresses in the interface of the measurement screw.
Surface smoothing for topological optimized 3D models
Authors: Bacciaglia Antonio , Ceruti Alessandro , Liverani Alfredo 
Published: August 2021

AbstractThe topology optimization methodology is widely applied in industrial engineering to design lightweight and efficient components. Despite that, many techniques based on structural optimization return a digital model that is far from being directly manufactured, mainly because of surface noise given by spikes and peaks on the component. For this reason, mesh post-processing is needed. Surface smoothing is one of the numerical procedures that can be applied to a triangulated mesh file to return a more appealing geometry. In literature, there are many smoothing algorithms available, but especially those based on the modification of vertex position suffer from high mesh shrinkage and loss of important geometry features like holes and surface planarity. For these reasons, an improved vertex-based algorithm based on Vollmer’s surface smoothing has been developed and introduced in this work along with two case studies included to evaluate its performances compared with existent algorithms. The innovative approach herein developed contains some sub-routines to mitigate the issues of common algorithms, and confirms to be efficient and useful in a real-life industrial context. Thanks to the developed functions able to recognize the geometry feature to be frozen during the smoothing process, the user’s intervention is not required to guide the procedure to get proper results.
A tale of two graph models: a case study in wireless sensor networks
Authors: Archibald Blair , Kulcsár Géza , Sevegnani Michele 
Published: August 2021

Abstract

Designing and reasoning about complex systems such as wireless sensor networks is hard due to highly dynamic environments: sensors are heterogeneous, battery-powered, and mobile. While formal modelling can provide rigorous mechanisms for design/reasoning, they are often viewed as difficult to use. Graph rewrite-based	modelling techniques increase usability by providing an intuitive, flexible, and
diagrammatic
form of modelling in which graph-like structures express relationships between entities while rewriting mechanisms allow model evolution. Two major graph-based formalisms are Graph Transformation Systems (GTS) and Bigraphical Reactive Systems (BRS). While both use similar underlying structures, how they are employed in modelling is quite different. To gain a deeper understanding of GTS and BRS, and to guide future modelling, theory, and tool development, in this experience report we compare the
practical
modelling abilities and style of GTS and BRS when applied to topology control in WSNs. To show the value of the models, we describe how analysis may be performed in both formalisms. A comparison of the approaches shows that although the two formalisms are different, from both a theoretical and practical modelling standpoint, they are each successful in modelling topology control in WSNs. We found that GTS, while featuring a small set of entities and transformation rules, relied on entity attributes, rule application based on attribute/variable side-conditions, and imperative control flow units. BRS on the other hand, required a larger number of entities in order to both encode attributes directly in the model (via nesting) and provide tagging functionality that, when coupled with rule priorities, implements control flow. There remains promising research mapping techniques between the formalisms to further enable flexible and expressive modelling.
The Efficacy, Safety, and Side Effects of Intrapericardial Triamcinolone Treatment in Children with Post-surgical Pericardial Effusion: A Case Series
Authors: van der Werff Manon H. , van der Kamp Hetty J. , Breur Johannes M. P. J. 
Published: August 2021

AbstractIntrapericardial triamcinolone can be used to treat chronic pericardial effusion (PE) in adults; however, pediatric data are lacking. In this case series we aim to evaluate the efficacy, safety, and side effects of intrapericardial triamcinolone in children with PE. The incidence and treatment of post-surgical PE from 2009 to 2019 were determined using the institutional surgical database and electronic patient records. Furthermore, a retrospective analysis of efficacy, safety, and side effects of intrapericardial triamcinolone treatment for chronic post-surgical PE was performed. The incidence of postoperative PE requiring treatment was highest after atrial septal defect (ASD) closure when compared to other types of cardiac surgery (9.7% vs 4.3%). Intrapericardial treatment with triamcinolone resolved pericardial effusion in 3 out of 4 patients. All patients developed significant systemic side effects. Surgical ASD closure is associated with an increased risk of development of PE requiring treatment. Intrapericardial triamcinolone is an effective treatment for chronic postoperative PE in children, but is always associated with significant systemic side effects. Close monitoring and treatment of adrenal insufficiency are mandatory in these cases.
Impact of the mouse model and molar amount of injected ligand on the tissue distribution profile of PSMA radioligands
Authors: Tschan Viviane J. , Borgna Francesca , Schibli Roger , Müller Cristina 
Published: August 2021

Abstract
Purpose
Various preclinical study designs are described in the literature for the evaluation of PSMA radioligands. In this study, [177Lu]Lu-Ibu-DAB-PSMA, an albumin-binding radioligand, and [177Lu]Lu-PSMA-617 were investigated and compared under variable experimental conditions.

Methods
In vitro cell uptake studies were performed with PC-3 PIP and LNCaP tumor cells using a range of molar concentrations (0.75–500 nM) of both radioligands. Biodistribution and SPECT/CT imaging studies were carried out with the respective tumor mouse models using 0.05 nmol and 1.0 nmol injected ligand per mouse.

Results
In both tumor cell lines, the uptake of the radioligands was increased when using low molar concentrations of the respective ligand. The observed saturation effect at high ligand concentrations was more pronounced for LNCaP cells that express PSMA at lower levels than for PC-3 PIP cells. At all investigated timepoints, the in vivo uptake of both radioligands was higher in PC-3 PIP tumors than in LNCaP tumors. A low molar amount of injected ligand increased the PC-3 PIP tumor uptake mainly for [177Lu]Lu-Ibu-DAB-PSMA; however, the molar amount of ligand was relevant for both radioligands when using LNCaP tumors. Renal retention of both radioligands was, however, up to fourfold higher during the first hours after application of a low ligand amount compared to the high ligand amount.

Conclusion
The results of this preclinical study underline the relevance of the tumor model and applied ligand amount for the characterization of PSMA radioligands. The application of equal preclinical study designs is crucial to allow the comparison of novel radioligands with existing ones and, thus, predict potential advantages of new radioligands in view of a clinical application.
Infant hydrocephalus: what valve first?
Authors: Hall Benjamin J. , Gillespie Conor S. , Sunderland Geraint J. , Conroy Elizabeth J. , Hennigan Dawn , Jenkinson Michael D. , Pettorini Benedetta , Mallucci Conor 
Published: August 2021

Abstract
Purpose
To review the use of different valve types in infants with hydrocephalus, in doing so, determining whether an optimal valve choice exists for this patient cohort.

Methods
We conducted (1) a literature review for all studies describing valve types used (programmable vs. non-programmable, valve size, pressure) in infants (≤ 2 years) with hydrocephalus, (2) a review of data from the pivotal BASICS trial for infant patients and (3) a separate, institutional cohort study from Alder Hey Children’s Hospital NHS Foundation Trust. The primary outcome was any revision not due to infection.

Results
The search identified 19 studies that were included in the review. Most did not identify a superior valve choice between programmable and non-programmable, small compared to ultra-small, and differential pressure compared to flow-regulating valves. Five studies investigated a single-valve type without a comparator group. The BASICS data identified 391 infants, with no statistically significant difference between gravitational and programmable subgroups. The institutional data from our tertiary referral centre did not reveal any significant difference in failure rate between valve subtypes.

Conclusion
Our review highlights the challenges of valve selection in infant hydrocephalus, reiterating that the concept of an optimal valve choice in this group remains a controversial one. While the infant-hydrocephalic population is at high risk of valve failure, heterogeneity and a lack of direct comparison between valves in the literature limit our ability to draw meaningful conclusions. Data that does exist suggests at present that there is no difference in non-infective failure rate are increasing in number, with the British valve subtypes in infant hydrocephalus, supported by both the randomised trial and institutional data in this study.
Effect of sub-technique transitions on energy expenditure and physiological load in the classical-style technique among elite male cross-country skiers
Authors: Carlsson Tomas , Wedholm Lars , Fjordell Wilma , Swarén Mikael , Carlsson Magnus 
Published: August 2021

Abstract
Purpose
To investigate whether sub-technique transitions in the classical-style technique are associated with increased energy expenditure and/or metabolic stress among elite male cross-country skiers.

Methods
Fifteen elite male skiers completed three 10-min treadmill roller-skiing tests, each of which consisted of 5 min using the diagonal-stride technique (DS) and 5 min using the double-poling technique (DP), combined in three various modes all ensuring comparable mechanical workload, at an inclination of 2.5° and a speed of 13 km/h. In the first and third tests, the participants used 5 min continuous DS followed by 5 min continuous DP, or vice versa (no transition (NT) test), whereas in the second test, they made transitions between DS and DP every 6 s (repeated transition (RT) test). The last 3 min of each 5-min stage was used to calculate the mean values of oxygen uptake ($${\dot{\text{V}}\text{O}}_{{2}}$$

V
˙

O

2

), respiratory exchange ratio (RER), metabolic rate (MR), mechanical work rate (MWR), and gross efficiency (GE). In addition, the pre–post-difference in blood lactate concentration (Ladiff) was determined for each test. Paired-samples t tests were used to investigate differences between tests.

Results
There were no significant differences between NT and RT tests regarding V̇O2, MR, MWR, or GE. Conversely, significant differences were found in RER and Ladiff, where the NT test was associated with higher RER and Ladiff values.

Conclusions
Roller skiing with repeated sub-technique transitions is not associated with an additional aerobic energy contribution; instead, the anaerobic energy contribution was lower compared to that under continuous use of DS and DP.
Seismo-acoustic characterisation of the 2018 Ambae (Manaro Voui) eruption, Vanuatu
Authors: Park Iseul , Jolly Arthur , Matoza Robin S. , Kennedy Ben , Kilgour Geoff , Johnson Richard , Garaebiti Esline , Cevuard Sandrine 
Published: August 2021

AbstractA new episode of unrest and phreatic/phreatomagmatic/magmatic eruptions occurred at Ambae volcano, Vanuatu, in 2017–2018. We installed a multi-station seismo-acoustic network consisting of seven 3-component broadband seismic stations and four 3-element (26–62 m maximum inter-element separation) infrasound arrays during the last phase of the 2018 eruption episode, capturing at least six reported major explosions towards the end of the eruption episode. The observed volcanic seismic signals are generally in the passband 0.5–10 Hz during the eruptive activity, but the corresponding acoustic signals have relatively low frequencies (< 1 Hz). Apparent very-long-period (< 0.2 Hz) seismic signals are also observed during the eruptive episode, but we show that they are generated as ground-coupled airwaves and propagate with atmospheric acoustic velocity. We observe strongly coherent infrasound waves at all acoustic arrays during the eruptions. Using waveform similarity of the acoustic signals, we detect previously unreported volcanic explosions at the summit vent region based on constant-celerity reverse-time-migration (RTM) analysis. The detected acoustic bursts are temporally related to shallow seismic volcanic tremor (frequency content of 5–10 Hz), which we characterise using a simplified amplitude ratio method at a seismic station pair with different distances from the vent. The amplitude ratio increased at the onset of large explosions and then decreased, which is interpreted as the seismic source ascent and descent. The ratio change is potentially useful to recognise volcanic unrest using only two seismic stations quickly. This study reiterates the value of joint seismo-acoustic data for improving interpretation of volcanic activity and reducing ambiguity in geophysical monitoring.
Increasing dental zirconia micro-retentive aspect through ultra-short pulsed laser microstructuring: study on flexural strength and crystal phase characterization
Authors: Garófalo Stephanie Assimakopoulos , Wehner Martin , Dohrn Andreas , Bilandžić Marin Dean , Roos Christian , Wierichs Richard Johannes , Meyer-Lueckel Hendrik , Aranha Ana Cecilia Corrêa , Esteves-Oliveira Marcella 
Published: August 2021

Abstract
Objectives
Although ultra-short pulsed laser (USPL) microstructuring has previously improved zirconia bond-strength, it is yet unclear how different laser-machined surface microstructures and patterns may influence the material’s mechanical properties. Therefore, the aim of this study was to assess the flexural strength of zirconia after different USPL settings creating three different geometrical patterns with structures in micrometer scale.

Methods
One hundred sixty zirconia bars (3Y-TZP, 21 × 4 × 2.1 mm) were prepared and randomly divided into five groups (n = 32): no surface treatment (negative control-NC); sandblasting with Al2O3 (SB); and three laser groups irradiated with USPL (Nd:YVO4/1064 nm/2-34 J/cm2/12 ps): crossed-lines (LC), random-hatching (LR), and parallel-waves (LW). Bars were subjected to a four-point flexural test (1 mm/min) and crystal phase content changes were identified by X-ray diffraction. Surface roughness and topography were analyzed through 3D-laser-profilometry and SEM. Data were analyzed with parametric tests for roughness and Weibull for flexural strength (α = 5%).

Results
LR (Mean[95%CI]: 852.0 MPa, [809.2–894.7]) was the only group that did not show a significantly different flexural strength than NC (819.8 MPa, [796.6–842.9]), (p > 0.05). All laser groups exhibited higher Weibull moduli than NC and SB, indicating higher reliability and homogeneity of the strength data. An increase of monoclinic phase peak was only observed for SB.

Conclusion
In conclusion, USPL created predictable, homogeneous, highly reproducible, and accurate surface microstructures on zirconia ceramic. The laser-settings of random-hatching (12 ps pulses) increased 3Y-TZP average surface roughness similarly to SB, while not causing deleterious crystal phase transformation or loss of flexural strength of the material. Furthermore, it has increased the Weibull modulus and consequently material’s reliability.

Clinical significance
Picosecond laser microstructuring (LR conditions) of 3Y-TZP ceramic does not decrease its flexural strength, while increasing materials realiability and creating highly reproducible and accurate microstructures. These features may be of interest both for improving clinical survival of zirconia restorations as well as enhancing longevity of zirconia implants.
Cellular effects of glycine and trehalose air-polishing powders on human gingival fibroblasts in vitro
Authors: Weusmann Jens , Deschner James , Imber Jean-Claude , Damanaki Anna , Leguizamón Natalia D. P. , Nogueira Andressa V. B. 
Published: August 2021

Abstract
Objectives
Air-polishing has been used in the treatment of periodontitis and gingivitis for years. The introduction of low-abrasive powders has enabled the use of air-polishing devices for subgingival therapy. Within the last decade, a wide range of different low-abrasive powders for subgingival use has been established. In this study, the effects of a glycine powder and a trehalose powder on human gingival fibroblasts (HGF) were investigated.

Methods
HGF were derived from three systemically and periodontally healthy donors. After 24 h and 48 h of incubation time, mRNA levels, and after 48 h, protein levels of TNFα, IL-8, CCL2, and VEGF were determined. In addition, NF-κB p65 nuclear translocation and in vitro wound healing were assessed. Statistical analysis was performed by ANOVA and post hoc Dunnett’s and Tukey’s tests (p < 0.05).

Results
Glycine powder significantly increased the expression of proinflammatory genes and showed exploitation of the NF-κB pathway, albeit trehalose powder hardly interfered with cell function and did not trigger the NF-κB pathway. In contrast to trehalose, glycine showed a significant inhibitory effect on the in vitro wound healing rate.

Conclusion
Subgingivally applicable powders for air-polishing devices can regulate cell viability and proliferation as well as cytokine expression. Our in vitro study suggests that the above powders may influence HGF via direct cell effects. Trehalose appears to be relatively inert compared to glycine powder.

Clinical relevance
With the limitations of an in vitro design, our study suggests that in terms of cell response, trehalose-based air-polishing powders show a reduced effect on inflammation.
BVOC Emissions From a Subarctic Ecosystem, as Controlled by Insect Herbivore Pressure and Temperature
Authors: Ghimire Rajendra P. , Silfver Tarja , Myller Kristiina , Oksanen Elina , Holopainen Jarmo K. , Mikola Juha 
Published: August 2021

AbstractThe biogenic volatile organic compounds, BVOCs have a central role in ecosystem–atmosphere interactions. High-latitude ecosystems are facing increasing temperatures and insect herbivore pressure, which may affect their BVOC emission rates, but evidence and predictions of changes remain scattered. We studied the long-term effects of + 3 °C warming and reduced insect herbivory (achieved through insecticide sprayings) on mid- and late summer BVOC emissions from field layer vegetation, supplemented with birch saplings, and the underlying soil in Subarctic mountain birch forest in Finland in 2017–2018. Reduced insect herbivory decreased leaf damage by 58–67% and total ecosystem BVOC emissions by 44–72%. Of the BVOC groups, total sesquiterpenes had 70–80% lower emissions with reduced herbivory, and in 2017 the decrease was greater in warmed plots (89% decrease) than in ambient plots (34% decrease). While non-standardized total BVOC, monoterpene, sesquiterpene and GLV emissions showed instant positive responses to increasing chamber air temperature in midsummer samplings, the long-term warming treatment effects on standardized emissions mainly appeared as changes in the compound structure of BVOC blends and varied with compounds and sampling times. Our results suggest that the effects of climate warming on the total quantity of BVOC emissions will in Subarctic ecosystems be, over and above the instant temperature effects, mediated through changes in insect herbivore pressure rather than plant growth. If insect herbivore numbers will increase as predicted under climate warming, our results forecast herbivory-induced increases in the quantity of Subarctic BVOC emissions.Graphic Abstract
Pattern and pace of morphological change due to variable human impact: the case of Japanese macaques
Authors: Geiger Madeleine 
Published: August 2021

AbstractHuman impact influences morphological variation in animals, as documented in many captive and domestic animal populations. However, there are different levels of human impact, and their influence on the pattern and rate of morphological variation remains unclear. This study contributes to the ongoing debate via the examination of cranial and mandibular shape and size variation and pace of change in Japanese macaques (Macaca fuscata). This species is ideal for tackling such questions because different wild, wild-provisioned, and captive populations have been monitored and collected over seven decades. Linear measurements were taken on 70 skulls from five populations, grouped into three ‘human impact groups’ (wild, wild-provisioned, and captive). This made it possible to investigate the pattern and pace of skull form changes among the human impact groups as well as over time within the populations. It was found that the overall skull shape tends to differ among the human impact groups, with captive macaques having relatively longer rostra than wild ones. Whether these differences are a result of geographic variation or variable human impact, related to nutritional supply and mechanical properties of the diet, is unclear. However, this pattern of directed changes did not seem to hold when the single captive populations were examined in detail. Although environmental conditions have probably been similar for the two examined captive populations (same captive locality), skull shape changes over the first generations in captivity were mostly different. This varying pattern, together with a consistent decrease in body size in the captive populations over generations, points to genetic drift playing a role in shaping skull shape and body size in captivity. In the captive groups investigated here, the rates of change were found to be high compared to literature records from settings featuring different degrees of human impact in different species, although they still lie in the range of field studies in a natural context. This adds to the view that human impact might not necessarily lead to particularly fast rates of change.