bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sporadic cell death in macroscale 3D tumor grafts with high drug resistance by activating cell-ECM interactions
Authors: Lee Sang Woo , Park Se Eun , Jeong Gi Seok 
Published: September 2021

Abstract
In the tumor microenvironment (TME), the extracellular matrix (ECM) provides a dynamic structure for cell adhesion and cancer cell motility, such as migration and invasion, as well as remodeling. Matrix metalloproteinases (MMPs) promote cancer cell motility, which contributes to inducing drug resistance and thereby acquiring aggressive features. The drug resistance-induced 3D in vitro tumor model can be an effective model for therapeutic strategies for anticancer drugs targeting aggressive cancer cells. Here, we describe highly drug-resistant multicellular tumoroids (MCTs)-ECM tumor grafts under a macroscale dense 3D in vitro model through a combination of numerous MCTs and a collagen matrix. MCTs-ECM tumor grafts promote the high activity of MMP2 and MMP9 compared to general MCTs and induced cancer cell motility. Then, after the administration of anticancer drugs, the tumor grafts show increased drug resistance, with both the sporadic distribution of necrotic cells and the reduction of apoptotic portions, by activating cancer cell motility. MCTs-ECM tumor graft could be useful as a macroscale tumor graft model for inducing drug resistance by activating cancer cell motility and evaluating the efficacy of anticancer drugs targeting cancer with aggressive features.
Photoluminescence and excited states dynamics of Tm2+-doped CsCa(Cl/Br)3 and CsCa(Br/I)3 perovskites
Authors: Plokker M P , Biner D A , Dusoswa N , Dorenbos P , Krämer K W , Van Der Kolk E 
Published: September 2021

Abstract
In this study, we systematically vary the Cl/Br and Br/I ratios in CsCaX3:Tm2+ (X = Cl, Br, I) and hereby gradually shift the positions of the Tm2+ 4f125d1-levels as relative to the two 4f13 levels. At low temperatures up to five distinct Tm2+ 4f125d1→4f13 emissions and the 4f13→4f13 emission can be observed. As the temperature increases, most of the 4f125d1→4f13 emissions undergo quenching via multi-phonon relaxation (MPR) and at room temperature only the lowest energy 4f125d1→4f13 and the 4f13→4f13 emission remains. For all compositions a 4f13→4f13 risetime phenomenon is then observed whose duration matches the 4f125d1→4f13 decay time. It shows the feeding of the 4f13 state after 4f125d1 excitation. Surprisingly, the feeding time becomes longer from Cl→Br→I, while the related 4f125d1-4f13 energy gap becomes smaller. The temperature dependence of the 4f125d1→4f13 and 4f13→4f13 emission intensity shows a anticorrelation as earlier observed in other systems and confirms that the feeding process is thermally stimulated. However, the thermally stimulated activation energies that control the feeding process, increase from Cl→Br→I despite our observation that the 4f125d1-4f13 energy gap becomes smaller. An analysis reveals that the unexpected behaviour in risetime and activation energy, as a function of composition, cannot be explained by 4f125d1→4f13 feeding via interband crossing, but more likely via MPR where the electron–phonon coupling strength decreases from Cl→Br→I. No strong relation was found between composition and the quantum efficiency (QE) of the 4f13→4f13 emission, due to the presence of fluctuations that are likely caused by intrinsic differences in sample quality. Nevertheless, a 4f13→4f13 QE of up to 70% has been observed and the materials can therefore be used in luminescence solar concentrators.
Trajectories of depressive symptoms and subsequent cognitive decline in older adults: a pooled analysis of two longitudinal cohorts
Authors: Zhu Yidan , Li Chenglong , Xie Wuxiang , Zhong Baoliang , Wu Yangfeng , Blumenthal James A 
Published: September 2021

Abstract

Background
the course of depression is variable, but it is unknown how this variability over time affects long-term cognitive decline.

Objective
to examine the relationship of different trajectories of depressive symptoms on rates of subsequent cognitive decline in older adults.

Design
population-based cohort study.

Setting
communities in the USA and England.

Subjects
17,556 older adults from the Health and Retirement Study and the English Longitudinal Study of Ageing.

Methods
depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale, and trajectories were calculated using group-based trajectory modelling. Global cognitive function and three cognitive domains of memory, executive function and temporal orientation were assessed for up to 18 years.

Results
five trajectories of depressive symptoms were identified. Compared with the ‘non-depressed’ trajectory, the ‘worsening depressive symptoms’ trajectory (pooled β = −0.016 standard deviation (SD)/year, 95% confidence interval (CI): −0.021 to −0.010), ‘persistent depressive symptoms’ trajectory (pooled β = −0.016 SD/year, 95% CI: −0.024 to −0.008), and ‘mild depressive symptoms’ trajectory (pooled β = −0.008 SD/year, 95% CI: −0.014 to −0.003) were associated with faster rates of cognitive decline, while no such association was found for the ‘improving depressive symptoms’ trajectory (pooled β = 0.001 SD/year, 95% CI: −0.010 to 0.012).

Conclusions
subthreshold depressive symptoms are associated with an increased rate of cognitive decline, while individuals who show improving depressive symptoms do not exhibit accelerated cognitive decline. These findings raise the possibility that maintaining depressive symptoms as low as possible and ignoring the clinical threshold, might mitigate cognitive decline in older adults.
World History and the Tasman Sea
Authors: Bashford Alison 
Published: September 2021

Abstract
Tracking and analyzing connection and mobility are now conventional in oceanic and world historiography and in many Indigenous historiographies. This article offers a counterargument and counterinstance. On both sides of the Tasman Sea lie human histories of almost incommensurably different temporal orders, separate for several centuries and suddenly connected in 1770, when Polynesians and Aboriginal people met. The Tasman Sea turns out to be one of the more fascinating fault lines for world historians who seek to fold ancient and modern, so-called prehistory and history, together into new periodizations of deep time and shallow time. It suggests the need seriously to consider a Tasman Divide as much as a connected Tasman World. This article recasts James Cook’s crossing of the Tasman Sea in 1770 less as a significant first contact between Englishmen and Indigenous Australians on that coast and more as a meeting of three peoples who occupied radically different temporalities: (1) the Polynesian Tupaia, (2) the Englishman James Cook, and (3) Aboriginal people whose names we do not know.
Invited Commentary: Intermittent Opioid Use and Ischemic Placental Disease—Clarifying Associations With Adverse Pregnancy Outcomes
Authors: Ananth Cande V , Brandt Justin S 
Published: September 2021

Abstract
Discomfort and, to a lesser extent, pain are common complaints during pregnancy, and some patients may turn to opioids for pain relief. Esposito et al. (Am J Epidemiol. 2022;191(5):759–768) report associations between intermittent exposure to opioids during pregnancy and the risk of ischemic placental disease—a syndrome that includes preeclampsia, placental abruption, births that are small for gestational age, and preterm delivery. They found that early opioid exposure in pregnancy was associated with a modestly increased risk for abruption, births that are small for gestational age, and preterm delivery, and both early and late exposures were associated with the greatest risk for these outcomes. Surprisingly, preeclampsia was not associated with opioid use. Through quantitative bias analysis, the authors cleverly tackle a number of biases to assess their roles in explaining the associations, including unmeasured confounding, outcome misclassification, and residual confounding; none exerted strong influences on the associations. Although the findings appear fairly robust on the surface, the lack of association between intermittent opioid use and preeclampsia, and important differences in characteristics of patients in the opioid-exposed group compared with the unexposed group, suggest that further study is needed to clarify the relationship between intermittent opioid use, lifestyle factors, and ischemic placental disease risk.
Jewish American Literature Against the World
Authors: Schreier Benjamin 
Published: September 2021

Abstract
By way of a brief genealogy of the Jewish American literary field and through the lens of recent attempts to imagine how comparative literature-based thinking about a concept of “world literature” can be critically productive for Jewish literary study, this article analyzes Jewish American literary studies’ prestige problem. Because it has persistently failed to theorize the intellectual and methodological assumptions underlying its practice, Jewish American literary study remains burdened by the essentialist implications of an ethnological historicism. This article ultimately argues that Jewish American literary study needs to take more seriously the possibilities offered by a materialist epistemology rather than the Jewish studies-based historicist ontology it has mostly taken for granted.
“My hope is that a Jewish American epistemology can operate outside the penumbra of a tired and played-out concept of ethnicity—a term that unavoidably, if spectrally, posits a biologistic object at the heart of its historicist project—even as it might still claim the mantle of Jewish-y-ness.”
American Magazines and the Cultural Production of Blackness
Authors: Young John K 
Published: September 2021

AbstractEurie Dahn’s Jim Crow Networks (2021) and E. James West’s Ebony Magazine and Lerone Bennett Jr. (2020) offer compelling examples of the two main literary historical approaches to periodical studies: A survey of several different types of magazines in relation to the social networks through which they were produced, distributed, and read, and a deep dive into the editorial orientation of a particular magazine, as shaped by a dominant individual presence. Both studies present detailed accounts of how these periodicals’ publics and counterpublics resisted (and sometimes reinforced) prevailing conceptions of racialized identity at important points in the twentieth century. But the material circumstances of those productions risk being misrepresented by the model of the network, so this review essay argues for the Bakhtinian chronotope as a more expressive metaphor for the temporal dimension of the magazine experience. This approach enables a more fully historicist understanding of how the various important literary figures represented here were perceived by their original periodical readers.
‘Except God, no substance can be conceived’: Spinoza on other substances
Authors: Noorloos Ruben 
Published: September 2021

AbstractThis paper argues that Spinoza held substances other than God to be inconceivable. It uses this claim to develop a novel response to the Problem of Other Substances (Garrett 1979, Barry 2019), the problem of explaining why some of Spinoza’s proofs for God’s existence cannot be used to prove the existence of a non-divine substance instead.
Endotoxin in Aerosol Particles from Metalworking Fluids Measured with a Sioutas Cascade Impactor
Authors: Dahlman-Höglund Anna , Schiöler Linus , Andersson Marianne , Mattsby-Baltzer Inger , Lindgren Åsa 
Published: September 2021

Abstract

Objectives
The aim of this study was to characterize personal occupational exposure to endotoxin in size-separated airborne particles of MWF aerosol, using a Sioutas cascade impactor (SCI).

Methods
Exposure to inhalable fractions of MWF aerosol and endotoxin was measured by personal sampling of 52 individuals over an 8-h work shift using a PAS-6 sampler in parallel with a SCI (&lt;0.25, 0.25–0.5, 0.5–1.0, 1.0–2.5, and 2.5–10 µm). Aerosol mass concentration was measured for each worker with a real-time instrument (DataRAM) during a full shift. Samples of MWF were collected from the machines and central tanks during the work shift.

Results
A total of 117 measurements of inhalable MWF aerosols were made among 52 workers. The geometric mean of inhalable MWF aerosol was 0.16 mg m−3 air. The geometric mean of endotoxin concentration on the inhalable sampler was 0.15 EU m−3. Airborne endotoxin was found on all size fractions from the impactor, with the major part seen in the fraction (2.5–10 µm). There was a correlation between the inhalable fraction of endotoxin measured by the PAS-6 sampler and on the SCI sampler (2.5–10 µm), estimated to be 0.51 for all samples (P &lt; 0.0001). The concentration of endotoxin varied between the MWFs, as did the proportion of Gram-negative bacteria among the culturable bacteria (&gt;80% in one MWF and &lt;1.5% in the other three).

Conclusions
The personal exposure to inhalable fractions of endotoxin contained in the MWF aerosol were low, where most of the endotoxin were found in fraction (2.5–10 µm), measured by SCI. There are differences between factories and MWF systems regarding the distribution of endotoxin and so results from one context should not be generalized to other plants and systems. Compressed air was used for less than 10 min shift−1. The mixed-effect model showed that working with open machines and grinding as cutting task were important determinants of exposure to inhalable aerosol. It is important to keep occupational exposure to aerosols low with the help of good ventilation systems, enclosed machines, and organization of work.
Monthlong Intubated Patient with Life-Threatening COVID-19 and Cerebral Microbleeds Suffers Only Mild Cognitive Sequelae at 8-Month Follow-up: A Case Report
Authors: Backman Linda , Möller Marika C , Thelin Eric P , Dahlgren Daniel , Deboussard Catharina , Östlund Gunilla , Lindau Maria 
Published: September 2021

Abstract

Objective
To elaborate on possible cognitive sequelae related to COVID-19, associated cerebrovascular injuries as well as the general consequences from intensive care. COVID-19 is known to have several, serious CNS-related consequences, but neuropsychological studies of severe COVID-19 are still rare.

Methods
M., a 45-year-old man, who survived a severe COVID-19 disease course including Acute Respiratory Distress Syndrome (ARDS), cerebral microbleeds, and 35 days of mechanical ventilation, is described. We elaborate on M’s recovery and rehabilitation process from onset to the 8-month follow-up. The cognitive functions were evaluated with a comprehensive screening battery at 4 weeks after extubation and at the 8-month follow-up.

Results
Following extubation, M. was delirious, reported visual hallucinations, and had severe sleeping difficulties. At about 3 months after COVID-19 onset, M. showed mild to moderate deficits on tests measuring processing speed, working memory, and attention. At assessments at 8 months, M. performed better, with results above average on tests measuring learning, memory, word fluency, and visuospatial functions. Minor deficits were still found regarding logical reasoning, attention, executive functioning, and processing speed. There were no lingering psychiatric symptoms. While M. had returned to a part-time job, he was not able to resume previous work-tasks.

Conclusion
This case-study demonstrates possible cognitive deficits after severe COVID-19 and emphasizes the need of a neuropsychological follow-up, with tests sensitive to minor deficits. The main findings of this report provide some support that the long-term prognosis for cognition in severe COVID-19 may be hopeful.
Overexpression of AGR2vH, an oncogenic AGR2 spliced transcript, potentiates tumorigenicity and proteomic alterations in cholangiocarcinoma cell
Authors: Yosudjai Juthamas , Inpad Chaturong , Pothipan Phattarin , Saisomboon Saowaluk , Surangkul Damrasamon , Phimsen Suchada , Hongsrichan Nuttanan , Wongkham Sopit , Jirawatnotai Siwanon , Roytrakul Sittiruk , Kaewkong Worasak 
Published: September 2021

ABSTRACT
The upregulation of anterior gradient 2 (AGR2) has been observed in cholangiocarcinoma (CCA) cells, nras-mutant zebrafish, and specimens derived from CCA patients. Our previous study reported AGR2 splicing into AGR2vH to facilitate CCA cell aggressiveness, while this work aims to investigate the molecular mechanisms underlying AGR2vH. First, AGR2vH upregulation was demonstrated in CCA tissues derived from patients. For in vitro studies, established AGR2vH-overexpressing KKU-213A cells were found to exhibit increased proliferation and clonogenicity. In vivo tumorigenicity assessed in a mouse model represented higher tumorigenic potential in AGR2vH-overexpressing cell xenograft mice. Next, LC-MS/MS was analyzed, indicating that AGR2vH may be associated with CCA cell proliferation via Wnt/β-catenin signaling pathway activation, which was verified by β-catenin expression and nuclear translocation. The current results provide evidence that AGR2vH upregulation promotes tumorigenicity in CCA cells linked with an alteration of CCA cell proteome.
Perceived risk structures the space use of competing carnivores
Authors: Rodriguez Curras Mauriel , Donadío Emiliano , Middleton Arthur D , Pauli Jonathan N 
Published: September 2021

Abstract
Competition structures ecological communities. In carnivorans, competitive interactions are disproportionately costly to subordinate carnivores who must account for the risk of interspecific killing when foraging. Accordingly, missed opportunity costs for meso-carnivores imposed by risk can benefit the smallest-bodied competitors. However, the extent to which the risk perpetuates into spatial partitioning in hierarchically structured communities remains unknown. To determine how risk-avoidance behaviors shape the space-use of carnivore communities, we studied a simple community of carnivores in northern Patagonia, Argentina: pumas (Puma concolor; an apex carnivore), culpeo foxes (Lycalopex culpaeus; a meso-carnivore), and chilla foxes (Lycalopex griseus; a small carnivore). We used multi-species occupancy models to quantify the space use within the carnivore community and giving-up densities to understand the behaviors that structure space use. Notably, we applied an analytical framework that tests whether the actual or perceived risk of predation most strongly influences the space use of subordinate carnivores although accounting for their foraging and vigilance behaviors. We found that there was a dominance hierarchy from the apex carnivore through the meso-carnivore to the subordinate small carnivore, which was reflected in space. Although both meso- and small carnivores exhibited similar predator avoidance behavioral responses to apex carnivores, the habitat associations of apex carnivores only altered meso-carnivore space use. The biases in risk management we observed for meso-carnivores likely translates into stable co-existence of this community of competing carnivores. We believe our analytical framework can be extended to other communities to quantify the spatial-behavioral tradeoffs of risk.
Emergence and repeatability of leadership and coordinated motion in fish shoals
Authors: Georgopoulou Dimitra G , King Andrew J , Brown Rowan M , Fürtbauer Ines 
Published: September 2021

Abstract
Studies of self-organizing groups like schools of fish or flocks of birds have sought to uncover the behavioral rules individuals use (local-level interactions) to coordinate their motion (global-level patterns). However, empirical studies tend to focus on short-term or one-off observations where coordination has already been established or describe transitions between different coordinated states. As a result, we have a poor understanding of how behavioral rules develop and are maintained in groups. Here, we study the emergence and repeatability of coordinated motion in shoals of stickleback fish (Gasterosteus aculeatus). Shoals were introduced to a simple environment, where their spatio-temporal position was deduced via video analysis. Using directional correlation between fish velocities and wavelet analysis of fish positions, we demonstrate how shoals that are initially uncoordinated in their motion quickly transition to a coordinated state with defined individual leader-follower roles. The identities of leaders and followers were repeatable across two trials, and coordination was reached more quickly during the second trial and by groups of fish with higher activity levels (tested before trials). The rapid emergence of coordinated motion and repeatability of social roles in stickleback fish shoals may act to reduce uncertainty of social interactions in the wild, where individuals live in a system with high fission-fusion dynamics and non-random patterns of association.
A network embedding framework based on integrating multiplex network for drug combination prediction
Authors: Yu Liang , Xia Mingfei , An Qi 
Published: September 2021

Abstract
Drug combination is a sensible strategy for disease treatment because it improves the treatment efficacy and reduces concomitant side effects. Due to the large number of possible combinations among candidate compounds, exhaustive screening is prohibitive. Currently, a large number of studies have focused on predicting potential drug combinations. However, these methods are not entirely satisfactory in terms of performance and scalability. In this paper, we proposed a Network Embedding frameWork in MultIplex Network (NEWMIN) to predict synthetic drug combinations. Based on a multiplex drug similarity network, we offered alternative methods to integrate useful information from different aspects and to decide the quantitative importance of each network. For drug combination prediction, we found seven novel drug combinations that have been validated by external sources among the top-ranked predictions of our model. To verify the feasibility of NEWMIN, we compared NEWMIN with other five methods, for which it showed better performance than other methods in terms of the area under the precision-recall curve and receiver operating characteristic curve.
Enhancing discoveries of molecular QTL studies with small sample size using summary statistic imputation
Authors: Wang Tao , Liu Yongzhuang , Yin Quanwei , Geng Jiaquan , Chen Jin , Yin Xipeng , Wang Yongtian , Shang Xuequn , Tian Chunwei , Wang Yadong , Peng Jiajie 
Published: September 2021

Abstract
Quantitative trait locus (QTL) analyses of multiomic molecular traits, such as gene transcription (eQTL), DNA methylation (mQTL) and histone modification (haQTL), have been widely used to infer the functional effects of genome variants. However, the QTL discovery is largely restricted by the limited study sample size, which demands higher threshold of minor allele frequency and then causes heavy missing molecular trait–variant associations. This happens prominently in single-cell level molecular QTL studies because of sample availability and cost. It is urgent to propose a method to solve this problem in order to enhance discoveries of current molecular QTL studies with small sample size. In this study, we presented an efficient computational framework called xQTLImp to impute missing molecular QTL associations. In the local-region imputation, xQTLImp uses multivariate Gaussian model to impute the missing associations by leveraging known association statistics of variants and the linkage disequilibrium (LD) around. In the genome-wide imputation, novel procedures are implemented to improve efficiency, including dynamically constructing a reused LD buffer, adopting multiple heuristic strategies and parallel computing. Experiments on various multiomic bulk and single-cell sequencing-based QTL datasets have demonstrated high imputation accuracy and novel QTL discovery ability of xQTLImp. Finally, a C++ software package is freely available at https://github.com/stormlovetao/QTLIMP.