bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tergynan treatment of bacterial vaginosis (BV) and urogenital candidosis (UGC)
Authors: Kira E. F. 
Published: November 2021

The data about treatment of BV and UGC by local application combined preparation of tergynan are submitted in the article. Efficiency of application of tergynan was compared with approved methods of treatment given diseases with using of 2% dalacin-vaginal cream (n=30) and jenamasolum (n=13). Was established that treatment BV was ascertained at 82,8% and UGC at 63,3% patients. Relapces were marked in 3 months after the ending of treatment accordingly at 18,8% patients with BV and 18,7% patients with UGC.
It is recommended to apply tergynan for treatment BV, UGC and to preventive maintenance of infectious complications after labor, abortions and vaginals operations.
Nickolai Vasilievitch Sklifosofsky and his contribution to development of operative gynecology
Authors: Tzvelev U. V. , Goda I. B. 
Published: November 2021

Speed of actions, the softness and tenderness of receptions, most severe cleanliness and neatness is made by the requirements, at which satisfaction can be eliminated adverse complications during our operations
(N.V. Sklifosofsky)
Saat çizme testinin çeşitli demans tiplerini ayırt etmedeki etkinliği
Authors: GÖÇMEZ YILMAZ Gülcan , OZGE Aynur , ŞAHİN Mekselina , KIRAL Kahraman 
Published: November 2021

Amaç: Bu çalışmanın amacı, demans tiplerini ayırt etmede saat çizme testinin (SÇT) etkinliğini araştırmaktır.
Gereç ve Yöntem: 48 Alzheimer hastalığı (AH), 68 vasküler demans (VaD) ve 13 frontotemporal demans (FTD) hastası çalışmaya dahil edildi. Tüm hastalara SÇT ile mini mental durum muayenesi (MMSE) ve diğer nörofizyolojik testler (ileri-geri sayım aralık, hesaplama testi, soyutlama testi, kelime hafıza testleri, boston adlandırma testi, kelime listesi hatırlama ve tanıma testleri) uygulandı. SÇT ve diğer nörofizyolojik testlerin skorları AH, VaD ve FTD grupları arasında karşılaştırıldı. SÇT ile diğer nörofizyolojik testler arasındaki ilişki değerlendirildi.
Bulgular: AH, VaD ve FTD grupları arasında SÇT testinin anlamlı bir fark olmadığı görülmüştür. Demans grupları arasında MMSE and geri sayım aralık skorları istatiksel olarak anlamlı bulunmuştur. MMSE ve SÇT testlerinin birlikte kullanımında özellkle AH ve VaD hastalarında pozitif korelasyon saptanmıştır. Ek olarak FTD tipi için SÇT ve boston anlamlandırma testi arasında da pozitif bir ilişki saptanmıştır.
Sonuç: SÇT primer demans tipi belirlemede benzersiz bir öngörücü değildir, ancak çalışmada kullandığımız nörofizyolojik test bataryaları arasında, özellikle MMSE ve SÇT nin birlikte kullanımı ve SÇT’nin diğer testlerle kombine kullanımının demans farklılaşmasında önemli bir yeri vardır.
Outcomes of Intervention in Children with Language Difficulties in Bangladesh
Authors: Shilpi Asma Begum , Sultana Nasrin , Akhter Shelina , Muslima Humaira , Khan Naila Zaman 
Published: November 2021

Background: Both clinical audits within hospitals, and population-based surveys of childhood disability in Bangladesh, have shown that large numbers of children have speech and language difficulties. This study determined the improvement of language skills of children presenting with difficulties to the Speech, Language and Communication (SLC) clinic of the Child Development Center (CDC) in Dhaka Shishu (Children) Hospital (DSH).
Methodology: This is a retrospective study where records of children enrolled from April 2009 to March 2014, who had visited the SLC Clinic at least 3 times over a span of 6 months were analyzed. Preverbal language skills, comprehension, and expressive language levels were measured informally based upon play and interactive sessions and observation of function. Interventions involved training parents on informal intervention techniques following some international standard guidelines. Pre and post-intervention observations on preverbal, comprehensive, and expressive language skills were recorded to determine outcomes.
Results: Of the 706 enrolled children 11.0%, 79.2%, 9.5%, .3% were 0-<2 years, 2-<5 years, >5-9 and 10-16 years old, respectively. 69.5% of children were males. Preverbal skills (attention span, awaiting, eye contact, attention sharing, turn-taking, copying), comprehension, and expressive language status showed significant improvement between the first and last visit (p= 0.000)
Conclusions: Interactive play, music, books, etc. are important means of improving communication between parents and children. Professionals working with developmentally delayed children need to be trained to utilize these strategies, with the provision of appropriate facilities within clinical settings. A large majority of children can be assisted to overcome delays and optimize their potential.
Formas de ingresso nos cursos técnicos de nível médio da Rede Federal de Ensino
Authors: Martins Alex Lara , Costa Alfredo 
Published: November 2021

O contexto da pandemia de covid-19 induziu as escolas a redefinirem os seus modelos pedagógicos. No caso da Rede Federal de Educação Profissional, houve a necessidade de se redefinirem, também, as formas de ingresso e os diferentes tipos de processo seletivo. Baseado nisso, este artigo apresenta a trajetória da educação profissional de nível médio no Brasil, focalizando os modos de ingresso e suas relações com o ambiente social e legal até 2019. Objetiva-se apresentar informações institucionais para se descreverem de modo sistemático as formas de admissão utilizadas até então. Os resultados da análise bibliográfica e dos diferentes sistemas de admissão poderão fornecer subsídios para a redefinição de políticas de acesso ao ensino profissionalizante de nível médio após o contexto da pandemia.
Correlation between Arterial Blood Oxygen Saturation, Underlying Diseases and Clinical Signs of COVID-19 Patients with Their Final Outcome
Authors: Nasiri Ebrahim , Zakeri Azizi Masoumeh , Aghajanipoor Kazem 
Published: November 2021

Introduction: COVID-19 can rapidly cause lung damage and severe respiratory distress and subsequently reduce oxygen saturation (SPO2), especially in generally ill patients, which may be exacerbated if severe clinical symptoms or underlying diseases are added. This may lead to deterioration of blood oxygenation or even increase the risk of death when severe clinical symptoms or underlying diseases are present. Therefore, the aim of this study was to Evaluation of the relationship between arterial blood oxygen saturation level and outcome in COVID-19 patients.Material and Methods: A cross-sectional study of 250 patients referred to Imam Sari Hospital with symptoms of respiratory infection, gastrointestinal, and general symptoms in January 2020 to September 2020. Data were analyzed using SPSS version 26.Results: 27 out of 250 patients died. There is a positive correlation between systemic patient, SPO2 and less than 90% with death results (P<0/02). Patients with heart disease (44.4%), cancer (30.1%), diabetes (11.1%), cerebrovascular accident (18.5%) died (P<0/05). There was no positive correlation between weakness, fever, dyspnea, nausea, and diarrhea and appetite loss with death.Conclusion: Based on the present study, it was found that patients whose clinical symptoms were associated with underlying disease and SPO2 to a severe and critical degree had a higher risk of adverse outcome such as death. People with underlying conditions such as DM, CVD, HTN, and a history of angiography and cancer are also more likely to die due to COVID-19. Most deaths in the present study had low SPO2 at before admission, indicating a strong association between patient mortality and severity of lung involvement and low SPO2.
Tratamiento tributario de las cooperativas en Argentina
Authors: Masón Rubén Alfredo 
Published: November 2021

Después de ahondar en el alcance que debe otorgarse al principio de la equidad tributaria, el autor enumera algunas particularidades que surgen de la propia naturaleza de las cooperativas y sostiene que esos rasgos distintivos requieren un tratamiento tributario de estas entidades diferente al que se aplica a otras organizaciones empresariales. A continuación recorre la situación de las cooperativas en los distintos impuestos vigentes en Argentina, para finalizar analizando una variada documentación referida a la promoción de las cooperativas tanto a nivel global como en su país.
Recibido: 02 julio 2021Aceptado: 16 octubre 2021
El movimiento cooperativo argentino y sus organizaciones: trayectoria y perspectivas
Authors: Vuotto Mirta 
Published: November 2021

El propósito del artículo es caracterizar la situación actual del cooperativismo argentino, en términos de su contribución económica y social, sus potencialidades y limitaciones. El texto está estructurado en tres secciones. En la primera se realiza una breve referencia al desarrollo del movimiento desde su origen, para considerar en la segunda sección los procesos de desarrollo durante el siglo XX y comienzos del siglo actual. Se considera en este ámbito el posicionamiento de las entidades según el interés de su membrecía, el sector de actividad al que pertenecen y los puestos de trabajo generados. En la tercera sección se analiza el papel del Estado y las políticas públicas orientadas al sector. Sobre estas referencias se presentan las principales conclusiones del análisis.
Recibido: 30 mayo 2021Aceptado: 02 septiembre 2021
The Factors Affecting Poverty Rate in Central Java Province 2018-2020
Authors: Solikhin Solikhin 
Published: November 2021

One of the Central Java Provincial Government programs is to reduce the number of people living in poverty. The Central Java Provincial Government target in 2020 was to lower poverty rate to below ten percent. Therefore, it is necessary to determine factors affecting the poverty rate in Central Java. This study aimed to analyze the effect of the Human Development Index, total population, Gross Regional Domestic Product (GDRP), and the impact of the Covid-19 pandemic on the poverty rate in regencies/municipalities in Central Java. The study on the impact of the Covid-19 pandemic on the poverty rate in Central Java Province has never been carried out. This study was different from the previous studies. This study used panel data regression by using 2018-2020 data from Statistics Indonesia (BPS). In this study, the result of the best model selection was the random effect model. The result of this study indicated that Human Development Index (HDI) had a negative and significant effect, total population had a positive and insignificant, GRDP had a negative and significant effect, and the impact of Covid-19 pandemic had a positive and significant effect on the poverty rate. Keywords: Impact of Covid-19, Human Development Index, Population, Poverty Rate, Gross Regional Domestic Product.
Antidiabetic Properties and Possible Mechanism of the Traditional Chinese Medicine Yi Qi Yang Yin Recipe in Db/db Mice
Authors: Lin Hongmei , Xu Ziying , Zhao Baosheng , Zhang Jingxuan , Zhang Zilan , Wang Weiling , Wang Ting 
Published: November 2021

Abstract
Background

Yi Qi Yang Yin Recipe (YQYY) is a well-known clinical prescription used in Traditional Chinese Medicine (TCM) that ameliorates type 2 diabetes. The aim of the present study was to comprehensively evaluate the efficacy of YQYY granules and explore their mechanism of action.
Methods

db/db mice were studied as an animal model of type 2 diabetes. After administered with YQYY for eight weeks, food and water consumption, levels of fasting blood glucose, glycosylated serum protein, and liver and pancreas tissue morphology were investigated. In addition, RT-PCR and Westernblot analysis were used to determine the expression of genes and proteins related to glycogen synthesis and gluconeogenesis pathways in the liver.
Results

YQYY resulted in significantly reduced food and water consumption, and lower fasting blood glucose and glycated serum protein levels. Furthermore, the proliferation of α-cells in db/db mouse pancreatic tissue decreased and liver tissue morphology was significantly ameliorated. YQYY upregulated the expression of phosphorylated GSK-3β and GS proteins in db/db mouse liver tissue, and promoted the synthesis of liver glycogen. Additionally, AMPK was activated, PEPCK and G6Pase gene expression levels decreased, and consequently, gluconeogenesis in the liver was inhibited. Therefore, YQYY improves diabetic phenotyp, suggesting that YQYY could be a prospective agent for preventing and treatment diabetes .
Molecular Mechanisms of Notopterygii Rhizoma Et Radix for the Treatment of Arrhythmia Based on Network Pharmacology
Authors: Wei PL , Qi Yifei , Tan Yupei , Long Dehuai , Xing Wenlong , Li Xiang , Shang Juju , Liu Hongxu 
Published: November 2021

Abstract
Background Many experiments showed that Notopterygii Rhizoma Et Radix (NRR) can resist arrhythmia, but the mechanism of its action has not clear. Here, we investigated the possible mechanisms of NRR by network pharmacology and molecular docking and verified them experimentally. Methods Active componds and targets of NRR were retrieved by the Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database andAnalysis Platform, SymMap, and the Encyclopedia of Traditional Chinese Medicine (ETCM) databases. Arrhythmia-related targets were acquired from Comparative Toxicogenomics Database (CTD) and GeneCards databases. Overlapping targets of NRR associated with arrhythmia were acquired via Venn diagram. DAVID was applied for GO and KEGG pathway analyses. Cytoscape software and its plug-in were used for PPI network construction, module division and hub nodes screening. AutoDock Vina and qRT-PCR were carried out for validation. Results The 21 active compounds and 57 targets were obtained. Of these, coumarin was the predominant category including 15 components and 31 targets. The 5 key targets of NRR in treating arrhythmia, and these targets are involved in the apoptotic process, extrinsic apoptotic signaling pathway in absence of ligand, endopeptidase activity involved in apoptotic process by cytochrome c. The main pathways are p53 signaling pathway, Hepatitis B and Apoptosis. The results of molecular docking and qRT-PCR display good effect on hub node regulation in NRR treatment. Conclusion NRR plays an important role in anti-apoptotic mediated by modulating p53 signaling pathway, which may provide insight into future research and clinical applications in arrhythmia therapy.
Evaluation of Plasma Assisted Noninvasive Surgery (PANIS) as a New Approach for the Treatment of Conjunctival Concretions; A Clinical Case Series
Authors: Nejat Farhad , Jadidi Khosrow , eghtedari shima , Nabavi Nazanin Sadat , Malekifar Pooneh 
Published: November 2021

Abstract
Purpose: Plasma is one of the newest therapies recently used in Conjunctivochalasis, Conjunctival Cyst, and Blepharoplasty. This study aimed to evaluate a quick treatment modality of conjunctival concretions using plasma as a noninvasive procedure.Design: Six eyes of six patients with conjunctival concretions were evaluated in a clinical case series.Methods: The procedure was performed using plasma spots generated by the white handpiece of the Plexr device. The eyelid was everted and concretions sublimated by plasma spots from the upper and lower eyelids. Refractive Errors, visual acuity (BCVA and UCVA), Ocular Surface Disease Index (OSDI), and Intraocular pressure (IOP) were measured before and after six months of the procedure.Results: The results of 6 months follow-up show that this effective method had no recurrence or side effects. Treatment was effective in all of the patients. No complication and recurrence was observed. The OSDI score was improved to the normal range. This method had no effects on Refractive Errors, Visual Acuity, and IOP. Conclusions: Based on the results, it seems that the PANIS method can be used as a practical, quick, and straightforward approach for the treatment of conjunctival concretions.
Identifying Symptom Clusters Among Pregnant Women During Early and Late Pregnancy
Authors: Zhang Yunxue , Xu Xiaofang , Xie Zihui , Li Yuanyuan , Zhao Di , Lv Gaorong , Li Ping 
Published: November 2021

Abstract
Objectives
Symptom assessment and management among women in early and late pregnancy remains concerned, in consideration of multiple co-occurring symptoms; however, evaluation of multidimensional nature of symptom experience (e.g., frequency, severity and distress) and relevant symptom cluster among them is insufficient. To shed light on this understudied field, our study investigated the status of multiple psychosomatic symptoms among women and identified symptom clusters in different gestational stages.
Methods
A convenience sample of 557 pregnant women were recruited at two tertiary hospitals in Shandong, China. They were asked to complete the Memorial Symptom Assessment Scale, and sociodemographic and clinical information. Spearman correlation analysis, partial correlation networks, and hierarchical cluster analysis were carried out to identify optimal number of symptom clusters.
Results
Top five scores for symptoms in early pregnancy were nausea, lack of appetite, feeling drowsy, lack of energy, and vomiting; and weight gain, difficulty sleeping, sweating, lack of energy, and dry mouth scored highly in late pregnancy. Four clusters (pregnancy reaction symptom cluster, mood-fatigue symptom cluster, change in libido and food taste symptom cluster, and dry mouth-bloating symptom cluster) were identified in early pregnancy, and three clusters (mood-fatigue symptom cluster, sleep-bloating symptom cluster, and fluid deficiency symptom cluster) were determined in late pregnancy.
Conclusion
Women experience multiple psychosomatic symptoms during pregnancy, and the manifestation of symptoms varies in different stages. Our study has provided new insights into symptom clusters of pregnant women. These results might potentially support the development of assessment and management of multiple co-occurring symptoms in this population.
Acupuncture For The Treatment of Diarrhoea-Predominant Irritable Bowel Syndrome (ATIBS-D): A Pilot Randomized Controlled Trial
Authors: Qi Ling-Yu , Yang Jing-Wen , Yan Shi-Yan , Tu Jian-Feng , She Yan-Fen , Li Ying , Chi Li-Li , Wu Bang-Qi , Liu Cun-Zhi 
Published: November 2021

Abstract
Background: Diarrhoea-predominant irritable bowel syndrome (IBS-D) is a common disease without an established optimal treatment. Acupuncture has promising effects on IBS-D, but high-quality evidence is scarce.Methods: In this parallel, multicenter, randomized controlled trial, participants with IBS-D were assigned to three groups: specific acupoints (SA), non-specific acupoints (NSA) and non-acupoints (NA). Participants received 12 sessions (3 sessions per week) treatment over 4 weeks. The primary endpoint was a composite response rate at week 4 of treatment. An eligible composite responder was responded in both abdominal pain intensity and stool consistency, defined as at least 30% decrease in the weekly average of worst abdominal pain score and 50% or greater reduction in the number of Type 6 or 7 stool days weekly compared with baseline.Results: Of 201 screened patients with IBS-D, 90 (44.8%) patients were enrolled, and 88.9% patients completed this study (26 in NSA; 27 in SA and NA). The composite response rates at week 4 were 46.7%, 46.7% and 26.7% (P＞0.05) of the participants who received SA, NSA and NA acupuncture, respectively. Adverse events were reported in 2 (6.7%) patients in SA, 3 (10%) patients in NSA and NA. There were no serious adverse events.Conclusions: The present study suggests that acupuncture treatment is feasible and safe for IBS-D patients. The further adequately powered trials can be achieved by recruiting more patients, increasing treatment dose, prolonging follow-up, choosing specific acupoints, setting up sham-acupuncture control, or a combination thereof.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000030670. Registered on 9 March 2020. https://www.chictr.org.cn/edit.aspx?pid=50167&htm=4
Interfacial Shear at the Atomic Scale
Authors: Rejhon Martin , Lavini Francesco , Khosravi Ali , Shestopalov Mykhailo , Kunc Jan , Tosatti Erio , Riedo Elisa 
Published: November 2021

Abstract
Understanding the interfacial properties between an atomic layer and its substrate is of key interest at both the fundamental and technological level. From Fermi level pinning to strain engineering and superlubricity, the interaction between a single atomic layer and its substrate governs electronic, mechanical, and chemical properties of the layer-substrate system. Here, we measure the hardly accessible interfacial transverse shear modulus of an atomic layer on a substrate. We show that this key interfacial property is critically controlled by the chemistry, order, and structure of the atomic layer-substrate interface. In particular, the experiments demonstrate that the interfacial shear modulus of epitaxial graphene on SiC increases for bilayer films compared to monolayer films, and augments when hydrogen is intercalated between graphene and SiC. The increase in shear modulus for two layers compared to one layer is explained in terms of layer-layer and layer-substrate stacking order, whereas the increase with H-intercalation is correlated with the pinning induced by the H-atoms at the interface. Importantly, we also demonstrate that this modulus is a pivotal measurable property to control and predict sliding friction in supported two-dimensional materials. Indeed, we observe an inverse relationship between friction and interfacial shear modulus, which naturally emerges from simple friction models based on a point mass driven over a periodic potential. This inverse relation originates from a decreased dissipation in presence of large shear stiffness, which reduces the energy barrier for sliding.
High Quality Development of Comprehensive University Medical Education In China: Problems And Path In The New Era
Authors: Lv Shaochun , Song Hanjun , Cheng Lulu 
Published: November 2021

Abstract
Background: In the new era, the situation of medical education in China has undergone significant and profound changes. Medical universities not only carry the historical mission of providing multidisciplinary talent support for the modernization of education, but also are endowed with the tasks and requirements of holding high quality medical education and promoting the construction of Health China. Objective To state the theory of medical education in the new era, this paper analyzes the problems existing in medical education of China's comprehensive universities, and gives the countermeasures and ideas of medical education development. ﻿Method: By using literature research, illustrating with examples, conclusion and reasoning methods to analyze and illustrate.Result: This paper interprets the connotation of high-quality development of medical education in the new era, thinks about the current situation features of domestic medical education such as the multilateral exploration of management mode of comprehensive university medical education, lists the main problems in medical education, and discusses the ideas and countermeasures to solve these problems in the future.Conclusion: The reform and development of medical education need to further improve the top-level design, and obtain the understanding and support from stakeholders. The comprehensive university should consider putting medical personnel training in the vision of Health China construction. Under the guidance of the national macro policy of holding high-level undergraduate education, it is imperative to persist in problem-oriented principle and make efforts to reform, using information technology to promote the sharing of educational resources among schools and form a synergy in medical education.