bluuebunny/crossref_metadata_2025_split huggingface dataset:
The significance of Serum Vitamin D Levels on Changes in Hematological Parameters After Chemotherapy in Patients with Breast Cancer
Authors: İnci Fatih , Karataş Fatih 
Published: January 2021

Objective: To investigate the relationship between serum Vitamin D (VD) level and the change of hematological parameters after chemotherapy in patients with breast cancer (BC) who received adjuvant Adriamycin and Cyclophosphamide (AC).
Material and Methods: A total of 74 BC patients who were treated with adjuvant 60 mg/m2 Adriamycin and 600 mg/m2 Cyclophosphamide (AC) were included in the study. VD levels, complete blood count (CBC) findings after 1st cycle AC were retrospectively recorded. The relationship between changes in CBC parameters according to VD levels and the presence of hematological toxicity was examined.
Results: The mean age was 55.11±9.97 years and the median VD level was 12.78 (4-53.40) ng/mL. In all patient groups, there was a significant decrease in the values of lymphocytes and monocytes after chemotherapy (p=0.030, p=0.024 respectively). In the correlation analysis, there was no correlation between VD levels and hemoglobin levels, the number of cells in CBC-1, and the amount of change in the number of cells in after chemotherapy. However, there was a negative correlation between VD level and platelet/lymphocyte ratio-1 (PLR-1), monocyte/lymphocyte ratio-1 (MLR-1) (p=0.025, r:-0.237; p=0.001, r:-0.370, respectively), but there was no correlation with PLR-2 and MLR-2 (p>0.05 all).
Conclusion: There was no relationship between VD levels and changes in hematological parameters and hematological toxicity related to AC chemotherapy in the patient with BC. VD level was inversely correlated with PLR-1 and MLR-1, which is generally accepted as inflammatory markers. This result showed that the levels of VD do not have a significant role in the development of hematological toxicity after AC chemotherapy in BC.
Prognostic significance of ferritin, D-dimer, lymphocyte / monocyte ratio and some biochemical markers in patients with SARS-CoV-2
Authors: Eser Ali , Kyio Nang Hseng 
Published: January 2021

Objective: The disease caused by Covid-19 that progress with severe acute respiratory distress syndrome (SARS) and can result in death, spread all over the world emerging from China. It is important to know the cases that expected to show a fatal course beforehand due to the cases resulting in death. In this study we analyzed the changes observed in ferritin, D-dimer, lymphocyte and monocyte levels, which are easily measured in patients, and evaluated how these determinants can be used as prognostic factors of the disease.
Materials and methods: One hundred patients who applied to Bezmialem Vakif University Hospital between April 2020 – May 2020, who were Covid-19 PCR positive, and had infiltration in their pulmonary computerised tomography scan, were included in the study. These patients were divided into two groups as normal service patients and intensive care unit patients. Ferritin, D-dimer, lymphocyte and monocyte levels, ALT, AST, LDH, and CRP levels were recorded at the time of diagnosis. Lymphocyte/monocyte ratio (LMR) was calculated.
Results: Ferritin and D-dimer levels, ALT, AST, LDH, and CRP levels were found to be statistically and significantly higher in the mortality group compared to non-mortality (p<0.05). LMR, on the other hand, was found to be statistically and significantly lower in the mortality group (p<0.05).
Conclusion: Ferritin, D-dimer levels and LMR can be determinant laboratory findings in the prognosis of the disease that are detected in the Covid-19 patients at the dime of diagnosis. More studies should be conducted to objectively evaluate disease-related prognostic factors.
Ventricular hypertrophy and ischaemic changes in Children with Sickle Cell Anaemia and its relationship with the Haemoglobin Concentration in Steady State
Authors: Ikegwuonu Charles , Ezeanosike Obumneme , Manyike Chuka , Ujunwa Fortune , Ikegwuonu Cordis 
Published: January 2021

Objective: The prevalence and burden of Sickle Cell Anaemia (SCA) in Nigeria are high and they contribute to childhood morbidity and mortality. Chronic anaemia and vaso-occlusion usually involve different organs. The involvement of the heart is a common complication of SCA, thus the need for early detection of cardiac abnormalities in children with SCA. To assess cardiac structure using ECG in children with SCA in steady-state and to determine the relationship between abnormal ECG findings and the participants’ haemoglobin concentration.
Material and Method: It was a cross-sectional study done in one of the tertiary hospitals in southeast Nigeria. The study participants were 164 children with SCA in steady state within the ages of 2 -17 years. A 12-lead ECG was carried out on the participants and their haemoglobin concentrations determined. The relationship between the presence of cardiac abnormality and independent variables like haemoglobin concentration, age and gender were analyzed.
Result: The prevalence of cardiac abnormality was 59.1%. The commonest cardiac structure abnormality was Left ventricular hypertrophy (LVH) (39.6%). Abnormality in the P-R interval was seen in 14.6%, while ST segment abnormality was seen in 18.3%. The mean Hb of those with abnormal ECG was lower than that of those without abnormal ECG, across each age group. Severe anaemia was a significant (p< 0.01) predictor of LVH. However, there was no significant association between the degree of anaemia and the occurrence of ST-segment (p: 0.26) and PR interval abnormalities (p: 0.52).
Conclusion: Cardiac anomalies are common findings in SCA children.
PENUMBUHAN MINAT BACA ANAK USIA 5 - 6 TAHUN DI KOMPLEK LANATA RESIDENCE 2
Authors: Khalidia Farisa , Rohita Rohita 
Published: January 2021

Minat baca anak-anak pada saat ini perlu ditumbuhkan. Berdasarkan hasil observasi diketahui bahwa anak-anak yang tinggal di Komplek Lanata Residence 2 memiliki minat baca yang rendah. Peran orangtua sangat dibutuhkan untuk menumbuhkan minat baca anak. Penelitian ini bertujuan untuk mengetahui proses penumbuhan minat baca anak di Komplek Lanata Residence 2, Jakarta Selatan. Subjek penelitian ini berjumlah 11 orang yang terdiri 5 (lima) orang ibu, 3 (tiga) orang anak perempuan dan 2 (dua) orang anak laki-laki. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Teknik analisis data yang digunakan adalah teknik analisis dari Miles and Huberman yang prosesnya dilakukan dalam tiga tahap yaitu reduksi data, display data, dan kesimpulan (<em>triangulasi</em> data). Hasil penelitian menunjukkan bahwa proses penumbuhan minat baca pada anak-anak di Komplek Lanata Residence 2 dilakukan dengan menggunakan metode tiru bunyi, coba tulis, latih baca, tebak contoh, dan latih kata dan kalimat. Media yang digunakan adalah buku bacaan kisah nabi, buku pelajaran, buku cerita atau novel
STIMULASI GERAK LOKOMOTOR ANAK USIA 1-4 TAHUN MELALUI METODE GERAK DAN LAGU
Authors: Nisa Intan , Suwardi Suwardi 
Published: January 2021

<p>Gerak lokomotor sangat melekat erat dan tidak dapat dipisahkan pada perkembangan motorik kasar anak, untuk itu perlu dilakukan stimulasi terkait kemampuan gerak lokomotornya yang sesuai dengan kelompok usia. Metode penelitian yang digunakan metode kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data yang digunakan adalah wawancara, observasi dan dokumentasi. Sumber data penelitiannya itu koordinator, guru <em>play class</em>, serta orangtua <em>play class</em>. Hasil penelitian menunjukkan bahwa pada kelompok kelas <em>Runner</em> (16-24 bulan) stimulasi kemampuan berjalan, berlari dan melompat dilakukan dengan menggunakan lagu <em>walk jump run, chochoc train</em>, <em>welcome to little jack</em>, serta <em>good bye song. </em>Pada kelompok kelas <em>Explorer</em> (2-3 tahun) stimulasi kemampuan berjalan, berlari dan melompat dilakukan denganmenggunakan lagu <em>walk jump run, chochoc train</em>, <em>welcome to little jack</em>, <em>jumping jack, </em>serta <em>good bye song. </em>Sementara pada kelompok <em>Kiddos</em> (3-4 tahun) pada kelompok kelas <em>Explorer</em> (2-3 tahun) menstimulasi kemampuan berjalan, berlari dan melompat menggunakan lagu<em> walk jump run, chochoc train</em>, <em>welcome to little jack</em>, <em>jumping jack, </em>serta <em>good bye song. </em>Pemberian stimulasi gerak lokomotor pada masing-masing usia, beberapa sudah sesuai dengan prinsip dasar stimulasi namun belum disesuaikan dengan usia atau kelompok anak seperti yang terdapat pada kriteria pemilihan media yakni pengelompokan sasaran. Saran yang dapat diberikan terkait stimulasi gerak dan lagu yang diberikan, hendaknya media yang digunakan diklasifikasikan berdasarkan kelompok usia. Sebaiknya pihak sekolah memberikan kegiatan dengan memperhatikan Peraturan Menteri 146 tahun 2014 serta guru dapat menggunakan media pembelajaran yang sesuai dengan usia anak, agar kemampuan anak dapat berkembang sesuai tahapan dan usianya.</p>
KEGIATAN SENTRA OLAH TUBUH DALAM MENSTIMULASI KEMAMPUAN MOTORIK KASAR ANAK
Authors: Hanum Afifah , Rohita Rohita 
Published: January 2021

Motorik kasar adalah bagian dari aktivitas motorik yang mencakup keterampilan otot-otot besar, gerakan ini lebih menuntut kekuatan fisik dan keseimbangan. Gerakan motorik kasar melibatkan aktivitas otot tangan, kaki,dan seluruh tubuh anak<em>.</em>Tujuan pengembangan motorik pada anak usia dini yaitu membantu meningkatkan keterampilan fisik motorik anak dalam melatih gerakan motorik kasar dan halus, meningkatkan kemampuan mengelola dan mengontrol gerakan tubuh, serta meningkatkan keterampilan tubuh dan cara hidup sehat sehingga dapat menunjang pertumbuhan jasmani yang kuat, sehat dan kuat. Oleh karena itu, keterampilan motorik kasar sangat penting untuk dikembangkan pada anak sejak usia dini untuk persiapan kehidupan di masa dewasanya. Penelitian ini bertujuan untuk mendeskripsikan kemampuan motorik kasar melalui kegiatan sentra olah tubuh di TK Islam Al Azhar 45 Grand Depok City. Metode penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data yang digunakan ialah wawancara, observasi dan dokumentasi. Sumber data pada penelitian ini adalah 1 orang kepala sekolah, 1orang guru dan 12 anak-anak kelompok A3 di sentra olah tubuh Taman Kanak-Kanak Islam Al Azhar 45 Grand Depok City. Hasil dari penelitian ini adalah stimulasi Kemampuan Motorik Kasar melalui pembelajaran sentra olah tubuh di Taman Kanak-Kanak Islam Al Azhar 45 Grand Depok City sudah cukup baik. Hal tersebut dapat tercapai karena terlihat dari 10 dari 12 orang anak mampu mengikuti kegiatan motorik kasar di sentra olah tubuh tanpa bantuan orang lain.
SOSIALISASI PERAN ORANG TUA DI MASA PANDEMIK COVID 19 DALAM PEMBELAJARAN DARING BAGI ANAK USIA SEKOLAH DASAR DESA CIKALONGSARI KARAWANG
Authors: Yayan Alpian  , Sri Wulan Anggraeni  , Vickry Rizky Faddillah  
Published: January 2021

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk mengetahui peran apa saja yang orang tua berikan selama mendampingi anak dalam kegiatan belajar di rumah pada anak usia Sekolah Dasar di masa pandemi Covid-19. Metode yang digunakan dalam kegiatan pegabdian kepada masyarakat ini melalui kegiatan yang dikemas secara workshop tentang peran orang tua di masa pandemic Covid-19 dalam pembelajaran daring bagi anak usia sekolah dasar, sedangakan yang menjadi khalayak sasarannya adalah para orang tua di Desa Cikalongsari Kecamatan Jatisari Kabupaten Karawang. Hasil kegiatan pengabdian kepada masyarakat ini memberikan pengetahuan dan pemahaman bagi orang tua dalam membantu, membimbing anak belajar secara daring di rumah dan memahami bagaimana pentingnya pengawasan bagi anak dalam proses pendidikan, sekaligus dapat merasakan bagitu berat tugas seorang guru dalam mendidik anak di sekolah.
Kata Kunci: peran orang tua, masa pandemi covid-19

This community service activity aims to find out what roles parents give while accompanying children in learning activities at home for elementary school aged children during the Covid-19 pandemic. The method used in community service activities is through activities that are packaged in workshops on the role of parents during the Covid-19 pandemic in online learning for elementary school aged children, while the target audience is parents in Cikalongsari Village, Jatisari District, Karawang Regency. The results of this community service activity provide knowledge and understanding for parents in helping, guiding children to learn online at home and understanding how important supervision is for children in the educational process, as well as being able to feel how heavy a teacher's task is in educating children at school.
Keywords: the role of parents, during the Covid-19 pandemic
Kreativitas Siswa dalam Menyelesaikan Soal Cerita Matematika di Masa Pandemi Pada Materi Persamaan Linear Dua Variabel
Authors: Rahmawati Arum Dwi 
Published: January 2021

Penelitian ini bertujuan mengetahui kreativitas siswa SMP dalam menyelesaikan soal cerita berkaitan dengan sistem persamaan linear dua variabel, yang meliputi langkah memahami masalah, merencanakan pemecahan, menyelesaikan masalah sesuai langkah kedua dan memeriksa kembali hasil dari yang diperoleh. Subyek penelitian adalah enam siswa kelas VIIIB SMP Negeri 3 Ngrambe. Pengambilan subyek berdasarkan tingkat prestasi belajar matematika siswa yaitu dua siswa berkemampuan tinggi, dua siswa berkemampuan sedang dan dua siswa berkemampuan rendah. Teknik pengumpulan data dilakukan dengan metode tes dan wawancara. Hasil penelitian ini adalah (1) Siswa kriteria tinggi menunjukkan bahwa siswa tersebut berkecenderungan memiliki profil kreativitas yang baik dalam menguraikan jawaban secara terperinci sesuai prosedur yang runtut, tepat dan benar dalam menyelesaikan soal cerita, (2) Siswa kriteria sedang menunjukkan bahwa siswa tersebut berkecenderungan memiliki profil kreativitas yang cukup dalam menguraikan jawaban secara terperinci yaitu menyelesaikan soal cerita dengan prosedur yang runtut tetapi kurang tepat, (3) Siswa kriteria rendah menunjukkan bahwa siswa tersebut berkecenderungan memiliki profil kreativitas yang kurang yaitu tidak dapat menyelesaikan soal cerita dengan prosedur yang benar sesuai langkah-langkah penyelesaian masalah.
Criminal Legal Protection Against Doctor Malpractice in Indonesia
Authors: Tongat  
Published: January 2021

One of the Human Rights elements that must be achieved in accordance with the ideals of the Indonesian
people is the Health aspect, the profession as a doctor devotes his/her knowledge to the public interests,
has freedom and independence which is oriented to human values in accordance with the code of ethics. In
implementing the code of medical ethics, it as much as possible avoids the occurrence of medical error. The
error can occur in the diagnostic stage such as error or delay in diagnosis, not implementing the appropriate
examination, using an examination method that is no longer used or does not act on the examination or
observation result, etc. The risk that occur if it is not carried out thoroughly and carefully, is that it will
result in a fatal error. The method used in this research is the normative juridism method, namely the
addition method by holding on to the applied norms or legal rules. The result in this research is the liability’s
manifestation of the doctor who performs medical malpractice as a form of criminal legal protection in
Indonesia, it is basically based on intentional or unintentional mistakes or negligence. If it results in the
victim’s death, it is equal to murder, and if the victim does not die it is called an act of persecution with the
sanction of persecution.
Mathematical Ecology, Evolution and the Social Sciences
Authors: Levin Simon A. 
Published: January 2021

The last few decades have seen an enhanced partnership between ecologists and social scientists, especially economists, in addressing the environmental challenges facing societies. Not only do ecology and economics, in particular, need each other; but also the challenges they face are similar and can benefit from cross-fertilization. At the core are scaling from the micro- to the macro, the development of appropriate statistical mechanics to facilitate scaling, features underlying the resilience and robustness of systems, the anticipation of critical transitions and regime shifts, and addressing the conflicts of interest between individual agents and the common good through exploration of cooperation, prosociality and collective decision-making. Confronting these issues will be crucial in the coming years for all nations, especially those in South Asia that will suffer in major ways from the consequences of overpopulation, climate change and other environmental threats.
Gas Chromatography-Mass Spectrometry Analysis of some Organochlorine Pesticides in Cowpea from South-South of Nigeria
Authors: Odion Emmanuel Eimiomodebheki , Usifoh Stella Folajole , Abolagba Joel Okhumen , Igene John Oamen , Usifoh Cyril Odianose 
Published: January 2021

Background: Organochlorine pesticides used illegally in the storage of cowpeas by some farmers to prevent attack by weevils were known to affect the health of human adversely.
Objectives: This study determined the mean concentration of aldrin, o,p΄-DDT, endosulfan, heptachlor epoxide and γ-HCH collected from some markets in South-South of Nigeria, compared these concentrations with set standards and ascertained the incidence of occurrence in cowpeas.
Methods: Forty-eight samples of cowpeas were randomly collected from local markets, identified, authenticated, extracted with dichloromethane using Soxhlet apparatus, cleaned-up with silica gel and analysed in a GC-MS using Restek column.
Results: The mean concentration of aldrin (445.08±6.43) µg/kg, heptachlor epoxide (188.84±3.42) µg/kg, o,p΄-DDT (182.24±5.13) µg/kg, endosulfan (142.94±2.05) µg/kg and γ-HCH (243.90±4.01) µg/kg in some markets were high and above the maximum residual limit.
Conclusion: Organochlorine pesticides are used in most of the markets in south-south Nigeria for the preservation of cowpeas and in some cases, two or more were detected in a given sample, which could be due to the addition of a combination of pesticides. The need for regular monitoring by regulatory agencies and for sensitisation of both the farmers and merchants on the danger of using these pesticides in cowpeas preservation is therefore germane.
DNA Cross-Links, Causative Agents and Repairing Agents
Authors: Nazir Taha , Nazir Saeed Ur Rashid , Hashmi Furqan K. , Shamim Rahat , Riaz Humayun , Munir Safia Sultana , Islam Azharul 
Published: January 2021

Context: deoxyribonucleic acid is under attack continuously by numerous exogenous and endogenous factors.DNA lesions are introduced by the DNA replication. This takes place because of mismatched ribonucleotides or bases that areincorporated randomly by the deoxyribonucleic acid polymerases.
Objectives: The study intended to examine the data from studies onDNA cross-links, causative agents and repairing agents.
Design: The research team performed a literature review, searching relevant literature databases. The sources of data included bioRxiv, medRxiv, Google Scholar, Embase, PsychINFO, and PubMed. The search terms were DNA cross-links, causative and repairing agent.
Setting: The study took place in the main library of the University of Sargodha.
Results: The study identified 39 unique studies that had reported and confirmed DNA cross-links, causativeand repairing agent. The studies found thatthe chemical reliability of Deoxyribonucleic acid is persistently being confronted by environmental and cellular genotoxic agents that create a varied arrangement of covalent nucleobase adduct.
Conclusion: The agents that produce these DRCs include ionizing radiation and UV light. Crosslinking agents are a diverse group of chemical molecules that comprise of two or additional reactive ends.It hasproved that homologous repair and nucleoside excision repair have cooperated closely and mitigated the genotoxic effect of DNA protein cross-links in the cells of Escherichia coli. DNA cross-linking therapies are used to treat various genetic diseases.These lesions can be detected by various methods and repaired using cross-linking agents such ascisplatin, and mitomycin.
Design and Performance Analysis of a Highly Efficient Polychromatic Full Stokes Polarization Modulator for the CRISP Imaging Spectrometer
Authors: de Wijn A. G. , de la Rodríguez J. Cruz , Scharmer G. B. , Sliepen G. , Sütterlin P. 
Published: January 2021

Abstract
We present the design and performance of a polychromatic polarization modulator for the CRisp Imaging SpectroPolarimeter (CRISP) Fabry–Perot tunable narrow-band imaging spectropolarimer at the Swedish 1 m Solar Telescope (SST). We discuss the design process in depth, compare two possible modulator designs through a tolerance analysis, and investigate thermal sensitivity of the selected design. The trade-offs and procedures described in this paper are generally applicable in the development of broadband polarization modulators. The modulator was built and has been operational since 2015. Its measured performance is close to optimal between 500 and 900 nm, and differences between the design and as-built modulator are largely understood. We show some example data, and briefly review scientific work that used data from SST/CRISP and this modulator.
Débat sur les voies de la transition énergétique
Authors: Holleaux Didier , Jancovici Jean-Marc 
Published: January 2021

Les voies de la transition énergétique ne sont pas aussi clairement tracées qu’on l’entend souvent dire. Les solutions prônées par les uns sont honnies par les autres, selon l’appréciation que chacun se forge des priorités et des risques acceptables. Quel est le vecteur le plus efficace de cette transition, ou le plus délétère, entre le nucléaire, le photovoltaïque, l’éolien, l’hydrogène… ? La protection de l’environnement doit-elle primer sur la croissance économique ? Comment identifier les leviers d’action les plus efficaces ?
Mélancolie, pouvoir et vérité(s) autour de La Mesnardière
Authors: Perez Stanis 
Published: January 2021

La fameuse possession de Loudun a donné lieu à une controverse médicale entre La Mesnardière et Duncan. Ce duel scientifique, apparemment remporté par le fidèle serviteur de Richelieu, n’est pas sans poser la question du rapport à la vérité, tant dans le domaine médical que dans celui, essentiel chez La Mesnardière, des lettres. N’y aurait-il pas un lien entre discours sur la mélancolie et définition des règles de la dramaturgie ? En d’autres termes, le problème de la vérité ne s’est-il pas dessiné, dans un premier temps, autour d’une réflexion sur le pouvoir du diable, contre celui de la bile noire, et sur les aléas d’une vérité bien négociable, tant chez les acteurs que chez les malades ?
La Poétique de La Mesnardière et les passions tragiques : art oratoire, ornement poétique et mimèsis dramatique
Authors: Sort Aurélia 
Published: January 2021

Dans La Poétique , La Mesnardière envisage les passions tragiques sous un jour rhétorique, et dans le cadre d’un pathétique « tendre » dont l’article redéfinit les contours. Mais la rhétorique n’y est pas contraire à la représentation dramatique car elle enseigne l’art d’imiter les passions pour promouvoir une tragédie éthique , qui cherche l’expression naturelle des caractères passionnés. Ces cadres d’une représentation vraisemblable sont pourtant mis à mal par l’ornement poétique des stances. L’ensemble de ce parcours théorique fait de La Mesnardière un témoin précieux de la formation du théâtre classique.
Une tragédie pour le Louvre : La Poétique de La Mesnardière
Authors: Steigerwald Jörn 
Published: January 2021

L’article s’intéresse à la question suivante : comment peut-on intégrer sinon légitimer un drame à la française dans la Poétique d’Aristote après la Querelle du Cid pour qu’il se présente comme le produit logique des règles aristotéliciennes ? Pour y répondre, La Mesnardière s’approche de la tragédie dans sa Poétique en mettant l’accent sur trois points : 1) la noblesse de la tragédie, 2) l’importance de la pitié, et 3° la place de l’amour dans la tragédie.