bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixed Convection Flow Along Vertical Thin Needles Containing Gyrotactic Microorganism with Variable Heat, Mass and Motile Microorganism Flux
Authors: Nima Nayema Islam , Alshuraiaan Bader , Ferdows M. 
Published: July 2021

Abstract
The problem of steady laminar mixed convection boundary layer flow along vertical thin needle with variable surface heat, mass and motile microorganism flux in the presence of gyrotactic microorganism is considered in this study. The dimensionless leading equations of continuity, momentum, concentraton and motile microorganism conservation are reduced to ordinary differential equations with the help of similarity transformations. The transformed governing equations are then numerically solved by using MATLAB BVP4C function. The research is reached to excellent argument by comparison in few cases between the results obtained from MATLAB and Maple algorithm with the help of dsolve command. Numerical calculations are carried out for various values of the dimensionless parameters of the problem which includes mixed convection parameter λ, power law index m, buoyancy parameters N1, N2 Lewis parameter Le, bioconvection lewis parameter Lb, Bioconvection peclet number Pe and also the parameter a representing the needle size. It is also shown from the results that the surface (wall) temperature, surface fluid concentration, surface motile microorganism concentration and the corresponding velocity, temperature, concentration and motile microorganism profiles are significantly induced by these parameters. The results are pictured and discussed in detail.
Comprehensive Analysis of Immune-Related Metabolic Genes in Lung Adenocarcinoma
Authors: Li FangFang , Huang Chun , Qiu LingXiao , Li Ping , zhang guojun 
Published: July 2021

Abstract
Purpose: The immunotherapy of lung adenocarcinoma has received more and more attention. Different immune cells can affect other metabolic genes and lifespan, and cell metabolism directly regulates immune cell functions. Therefore, it is crucial to explore the role of immune-related metabolic genes in lung adenocarcinoma. Methods: This study screened and studied immune-related metabolic genes from three aspects. First of all, we divide them into three categories based on different immune characteristics and research immunity and clinical pathology. Secondly, we used LASSO regression analysis to screen the immune-related metabolic genes and constructed the clinical prediction model for the screened genes. Finally, we selected the intersection of immune metabolism genes highly expressed in tumor sites and immune metabolism genes that are negatively related to survival and obtained potential genes. Results: We first identified immune-related metabolic genes and immune cells that may affect tumor progression in lung cancer. Then, through LASSO regression analysis, we screened out nine hub genes (TK1, TCN1, CAV1, ACMSD, HS3ST2, HS3ST5, AMN, ADRA2C, ACOXL) and constructed a prognostic model. Finally, through the screening of tumor-related immune metabolism genes, we obtained five hub genes (HMMR, PFKP, RRM2, TCN1 and TK1). Our qRT-PCR result also showed that RRM2 positively correlates with CDK2, CDK4, CDK6, CDK8.Conclusion: We conduct a comprehensive analysis of the immune infiltration of the tumor microenvironment of lung cancer, and finally determined RRM2 as a promising immune metabolism checkpoint for lung adenocarcinoma based on the high correlation of RRM2 with immune cells and CDK family.
Phase-State Dependent Silica Nanoparticle Uptake of Giant Unilamellar Vesicles
Authors: Kamenac Andrej , Sirch Manuel , Neidinger Simon , Westerhausen Christoph 
Published: July 2021

Abstract
We quantify endocytosis-like nanoparticle uptake of model membranes as a function of temperature and therefore phase state. As model membranes, we use giant unilamellar vesicles consisting of 1,2-dipentadecanoyl-sn-glycero-3-phosphocholine (15:0 PC). Time-series micrographs of the vesicle shrinkage show uptake rates that are a highly non-linear function of temperature. A global maximum appears close to the main structural phase transition at T = Tm + 3 K, and a minor peak at the pretransition T = Tp = 22 °C. The quality of the kinetics linear fits reveals a deviation from the linear trend at the vesicle shrinkage peaks. To further elucidate the origin of the shrinkage peak, we performed force spectroscopy on a supported lipid bilayer. The results indicate a collapse of the adhesion energy at the structural phase transition. Further using literature results on the bending modulus as function of temperature and Helfrich’s model, this allows us to make qualitative conclusions on the membrane tension as function of temperature.
Preparation and Performance Study of Anode Self-Humidifying Gas Diffusion Layer
Authors: Li Tianya , Zhou Ke , Lin Guangyi 
Published: July 2021

Abstract
Hydrogen is oxidized into H+ and e- on the anode side of fuel cell. H+ are transported from anode to cathode of fuel cell in the form of H3+O. When fuel cell is running under low humidity, the relatively small water content will reduce H+ transmission efficiency and causes an increase in ohmic impedance. In order to solve this problem, this paper prepared self-humidifying gas diffusion layer （GDL） by spraying method. The content of PTFE in the microporous layer (MPL) near carbon paper side is relatively high, and the content of PTFE in MPL near catalyst layer side is relatively low, thus forming MPL with graded hydrophobic structure. Since the MPL near catalyst layer side is relatively hydrophilic, it will condense into liquid water when external humidifying gas passes, thereby generating self-humidifying effect. Through research, self-humidifying GDL with double MPL structure can produce good self-humidification.
Management of elderly traumatic ankle arthritis with Ilizarov External Fixation: A Retrospective Study
Authors: Li Jun , Wang Wenzhao , Li Bohua , Li Mingxin , Liu Lei 
Published: July 2021

Abstract
Objective To evaluate the clinical effect of Ilizarov external fixation and ankle arthrodesis in the treatment of elderly traumatic ankle arthritis.Methods From June 2015 to August 2019, 72 patients with elderly traumatic ankle arthritis were treated with arthrodesis through Ilizarov external fixation technique in our institution, 38 cases were males and 34 cases were females, with an average of 65.4 years (ranging from 60 to 74). Conventional double-feet loading positive and lateral X ray films were taken before operation. Angle between the tibia anatomic axis and the line segment of inside and outside of talus vertex was measured to evaluate the degree of talipes varus and valgus. Functional assessments were performed using Foot and Ankle pain score of American Orthopedics Foot and Ankle Society(AOFAS) and Visual Analogue Scale(VAS) .Results All of the patients acquired effective postoperative 18-49 months follow-up, with an average of 31.5 months. All ankles achieved bony fusion, the clinical healing time was 12.7 weeks on average(11~18 weeks).The AOFAS score was 45.36±6.43 preoperatively and 80.25±9.16 at 12 months post operation, with a statistically significant difference(P<0.0001). The VAS score was 8.56±1.85 on average preoperatively and 2.72±0.83 at 12 months post operation, with a statistically significant difference ( P<0.0001). The angle of anatomical tibial shaft and the line segment of inside and outside of talus vertex on X-ray image was 101.93°±4.12° preoperatively and 94.45°±2.37° at 12 months post operation, with a statistically significant difference(P<0.0001). The results of functional evaluation indicated that 44 patients(61.1%) had excellent results, 18 (25%) had good results, and 10 (13.9%) had fair results.Conclusion Satisfactory curative effect can be obtained through Ilizarov external fixation and ankle arthrodesis in the treatment of elderly traumatic ankle arthritis, while large sample randomized controlled trials are still needed.
Facile synthesis of N-doped graphene encapsulated Pd@N/C catalyst and its efficient application in cascade flow synthesis of amines
Authors: Liu Jianguo , Sun Jiangmin , Song Yanpei , Lin Shanshan , Ma Longlong 
Published: July 2021

Abstract
N-methylamines, as an important class of chemicals, crucial building blocks, have been widely used in pharmaceutical companies and materials synthesis. Transition metal-catalyzed synthesis of N-methylamines, especially the heterogeneous catalyzed N-methylation of amines via different C1 sources has become the most promising methodology, due to the environmentally friendlier process and the recyclable and easily accessible catalysts. However, these reactions generally require activated toxic methyl iodide or dimethyl sulfoxide, and homogeneous catalysts or Raney nickel catalyst. The synthesis of amines still suffering from narrow scopes of amines, harsh reaction conditions, low selectivity of the desired products, and against the requirements of atomic economy and sustainable green environment. Herein, we developed a novel facile synthesis of nitrogen-doped graphene encapsulated Pd@NC nanocatalysts. The resulting heterogeneous catalyst was active for the synthesis of amines (more than 83 examples, yield up to 99%). The nitrogen-doped effect was unlike the previous report that poisoned the metal, it could increase the interaction with the active metal resulting in excellent stability. As far as we know, for the first time, the developed N-doped graphene encapsulated Pd@NC nanocatalyst showed excellent stability and activity of amines synthesis in the 20 times’ recycling test, industrially applicable flow reactor 2880 minutes’ test, and 99% purity of primary amine and tertiary amines product preparation test. Moreover, we have also shown the high atomic economy and environmentally friendlier tandem flow synthesis of N, N-dimethylamine products via the combination of reduction of nitrobenzene and N-methylation of amines, using the single one Pd@NC nanocatalyst with H2O as the only by-product. Upon our knowledge, this is a novel example of primary amine and tertiary amine synthesis methodology with the combined cascade reaction and flow process of nitrobenzene reduction and primary amines N-methylation with a single heterogeneous catalyst.
Assessing the use of Hospital Information Systems (HIS) to support decision-making: A cross-sectional study in public hospitals in ​​Huila, sanitary region of southern Angola.
Authors: Sanjuluca Tomas Hambili , Correia Ricardo Cruz , de Almeida Anabela Antunes 
Published: July 2021

Abstract
Background

Some previous studies have reported that hospital medical assistance in Angola lacks efficiency. There is no production of information on health financing or even health spending that could help monitor equity. Hospital information systems (HIS) could be relevant tools to inform hospital managers, supporting better management decisions in healthcare and, consequently, increasing efficiency. Nonetheless, the effective use of these systems by hospital managers to support decision-making in Angola is unknown. This study aimed to analyze the use of HIS as a tool to support decision-making by hospital managers in Huila, Angola.
Methods

This is a descriptive–cross-sectional study that was inducted between July and September 2017 in seven hospitals in Huila Province, Angola, specifically in Lubango and Matala cities. Each hospital board included four to six managers (e.g., general, clinical, administrative, nursing, diagnostic and therapeutic, and teaching and training managers). Thirty-six members of the hospital boards filled on a self-questionnaire that consisted of twenty questions based on the following issues: characterization of the interviewee's profile; availability of information in the institution; quality and usefulness of the available operational information and satisfaction with the existing HIS. Perform data analysis with IBM SPSS Statistics, version 21.0
Results

At least ⅔ of the participants reported being unsatisfied or relatively satisfied with each of the HIS-specific features that were assessed. More than 50%have rarely or never used the health information system to support decision-making, and 47.2% have never noted audits performed in their institution. Only 25% of the participants considered that the HIS stored information was satisfactory to calculate the rate of service indicators.
Conclusion

Our study showed that most hospital managers don’t use hospital information systems as tools to support management-related decision-making in Angola. Improving the Hospital information systems, ability to compute adequate indicators, and providing training on HIS usage to hospital managers could be targets of future interventions to support better management-related decision-making in Angolan healthcare.
Chicken egg white — characteristics of its properties and the prospects for functional foods development
Authors: Stefanova I. L. , Klimenkova A. Yu. , Shakhnazarova L. V. , Mazo V. K. 
Published: July 2021

The overview presents the literature data and the results of our own research on prospects of using the chicken eggs as the basis of functional foods. The composition of chicken eggs and their components, characteristics of egg white proteins properties are presented thereto. The biologically active compounds included into egg composition are analyzed. The data on the biological value of egg white are given. The characteristic of egg white foaming ability is presented. It has been shown that the ability of proteins to form stable intermolecular structures, especially with partially denaturated proteins, allows them forming viscoelastic superficial films that ensure foam stability. The high foaming ability of chicken egg protein macromolecules is directly related to their interphase properties, i. e. the ability to form interphase layers at the “liquid — gas” interface. The foaming properties of the various egg proteins are not equal, and therefore they contribute to foaming properties at various extents. The model of egg white proteins gelation is considered and the factors influencing the gelation process are described. It has been shown that very important changes in proteins properties are caused by denaturation. The proteins lose their ability to hydrate; the protective aqueous shell around the globules disappears, the proteins stick together, grow larger and lose solubility. This process is called coagulation. The influence of denaturation and aggregation on variations of protein properties is described below. Data on protein fortification with functional ingredients (calcium, iodine, plant polyphenols) and creation of functional egg and meat foods are presented here.
Design, implementation, control and optimization of single stage pilot scale reverse osmosis process
Authors: Guna G. , Prabhakaran D. , Thirumarimurugan M. 
Published: July 2021

Abstract
In this paper, a single-stage pilot-scale reverse osmosis (RO) process is considered. The process is mainly used in various chemical industries such as dye, pharmaceutical, beverage, and so on. Initially, mathematical modeling of the process is to be done followed by linearization of the system. Here a dual loop construction with a master and a slave is used. The slave uses the conventional proportional integral derivative (PID) with a reference model of the RO process and the master uses the fractional order proportional integral derivative (FOPID) with a real time RO process. The slave's output is compared with output of the real time RO process to obtain the error which is in turn used to tune the master. The slave controller is tuned using Ziegler Nichols method and the error criterion such as integral absolute error (IAE), integral squared error (ISE), integral time squared error (ITSE), integral time absolute error (ITAE) are calculated and the minimum among them was chosen as the objective function for the master loop tuning. Hence the tuning of the controller becomes a whole. Therefore two optimization techniques such as particle swarm optimization (PSO) and bacterial foraging optimization algorithm (BFO) are used for the tuning of the master loop. From the calculations, the ITSE had the minimum value among the performance indices, hence it was used as the objective function for the BFO and PSO. The best-tuned values will be obtained with the use of these techniques and the best among all can be considered for various industrial applications. Finally, the performance of the process is compared with both techniques and BFO outperforms the PSO from the simulations.
Interes prawny a proces kościelny. Glosa aprobująca do wyroku Naczelnego Sądu Administracyjnego z dnia 08 maja 2015 r., II OSK 2416/13
Authors: Niemczycki Dawid 
Published: July 2021

This gloss concerns the judgment of the Supreme Administrative Court of 8 May 2015, case II OSK 2416/13, in which the court stated that the legal interest conditioning the disclosure of personal data may be enjoyed not only in a trial before a secular court, but also in proceedings before ecclesiastical court.
The gloss layout includes the introduction, the thesis of the order, premises of the factual and legal status, arguments of the Supreme Administrative Court, evaluation of the judgment and the conclusion.
The author fully shares the justification of the judgment. Moreover, he points to the ground-breaking approach to the process of nullity of marriage before the ecclesiastical court, which is the basis for granting a legal interest in the procedure of disclosing personal data before a public administration body.
Przeszkody małżeńskie tajne i publiczne według Codex Iuris Canonici z 1917
Authors: Jakubiak Tomasz 
Published: July 2021

Umiejętność rozróżnienia przeszkód małżeńskich tajnych (impedimenta occulta) i przeszkód publicznych (impedimenta publica) okazuje się konieczna przy stosowaniu norm prawa kanonicznego Kościoła katolickiego. Do tego podziału odwołują się przepisy KPK 1983 i KKKW dotyczące: dyspensowania od przeszkód małżeńskich (kan. 1079 § 3 KPK/83, kan. 796 § 2 KKKW), zapisu faktu udzielenia dyspensy (kan. 1082 KPK/83, kan. 799 KKKW), a także uważnienia małżeństwa (kan. 1158-1159 KPK/83, kan. 845-846 KPK/83).
Dostrzegając brak jednomyślności wśród współczesnych kanonistów co do tego, jak należy interpretować ustawową definicję przeszkody publicznej i tajnej, zapisaną w kan. 1074 KPK/83 i kan. 791 KKKW, autor niniejszego artykułu postanowił przeanalizować kształtowanie się doktryny i dyscypliny Kościoła katolickiego w tej materii w latach 1917- 1983, czyli w okresie obowiązywania norm ogłoszonych w kodeksie Pio-Benedyktyńskim. Metoda ta wydaje się odpowiednia ze względu na fakt, że we wszystkich kodeksach Kościoła katolickiego promulgowanych po 1917 roku ustawodawca w ten sam sposób definiował przeszkodę publiczną i przeszkodę tajną (Publicum censetur impedimentum, quod probari in foro externo potest; secus est occultum). Wnioski z badań przeprowadzonych na potrzeby niniejszego opracowania ukazują również przyczyny, które miały wpływ na brak jednoznaczności w określeniu zakresu przywołanych przeszkód w doktrynie i dyscyplinie Kościoła w latach 1917-1983.
Antimicrobial Peptides with pH-Dependent Activity and Alkaline Optima:
Their Origins, Mechanisms of Action and Potential Applications
Authors: Phoenix David A. , Harris Frederick , Dennison Sarah R. 
Published: July 2021

:
A number of disorders and diseases are associated with conditions of high pH, and many
conventional antibiotics lose their efficacy under these pH conditions, generating a need for novel
antimicrobials. A potential solution to fulfill this need is Antimicrobial Peptides (AMPs) with high
pH optima. This review shows that a variety of anionic and cationic AMPs with this pH dependency
are produced by creatures across the eukaryotic kingdom, including rabbits, cattle, sheep, fish, crabs
and frog. These AMPs exhibit activity against viruses, bacteria, and fungi that involve membrane
interactions and appear to be facilitated by a variety of mechanisms that generally promote passage
across membranes to attack intracellular targets, such as DNA or protein synthesisand/or membrane
lysis. Some of these mechanisms are unknown, but those elucidated include the use of bacterial
pores and transporters, the self-promoted uptake pathway, and established models of membrane
interaction, such as the carpet mechanism, toroidal pore formation, the adoption of tilted peptide,
and the SHM model. A variety of potential roles have been proposed for these AMPs, including use
as antivirals, antibacterials, antifungals, adjuvants to antimicrobial therapy, biomarkers of disease,
and probes for pathogenic microbes. In this review, these properties are described and discussed,
emphasizing the antimicrobial mechanisms used by these AMPs and the pH dependency of these
mechanisms.
Clinical Development of Cell Therapies to Halt Lysosomal Storage Diseases:
Results and Lessons Learned
Authors: Graceffa Valeria 
Published: July 2021

:
Although cross-correction was discovered more than 50 years ago, and held the promise of
drastically improving disease management, still no cure exists for lysosomal storage diseases (LSDs).
Cell therapies have the potential to halt disease progression: either a subset of autologous cells can be
ex vivo/ in vivo transfected with the functional gene or allogenic wild type stem cells can be transplanted.
However, the majority of cell-based attempts have been ineffective, due to the difficulties in
reversing neuronal symptomatology, in finding appropriate gene transfection approaches, in inducing
immune tolerance, reducing the risk of graft versus host disease (GVHD) when allogenic cells are
used and that of immune response when engineered viruses are administered, coupled with a limited
secretion and uptake of some enzymes. In the last decade, due to advances in our understanding of lysosomal
biology and mechanisms of cross-correction, coupled with progresses in gene therapy, ongoing
pre-clinical and clinical investigations have remarkably increased. Even gene editing approaches
are currently under clinical experimentation. This review proposes to critically discuss and compare
trends and advances in cell-based and gene therapy for LSDs. Systemic gene delivery and transplantation
of allogenic stem cells will be initially discussed, whereas proposed brain targeting methods will
be then critically outlined.
Design of Novel Phosphopantetheine Adenylyltransferase Inhibitors: A Potential New Approach to Tackle Mycobacterium tuberculosis
Authors: Primi Marina C. , Tavares Maurício T. , Klein Larry L. , Izard Tina , Sant'Anna Carlos M. R. , Franzblau Scott G. , Ferreira Elizabeth I. 
Published: July 2021

Background:
Tuberculosis (TB) has been a challenging disease worldwide, especially for
the neglected poor populations. Presently, there are approximately 2 billion people infected with TB
worldwide and 10 million people in the world fell ill with active TB, leading to 1.5 million deaths.

Introduction:
The classic treatment is extensive and the drug- and multi-drug resistance of Mycobacterium
tuberculosis has been a threat to the efficacy of the drugs currently used. Therefore, the rational
design of new anti-TB candidates is urgently needed.

Methods:
With the aim of contributing to face this challenge, 78 compounds have been proposed
based on SBDD (Structure-Based Drug Design) strategies applied to target the M. tuberculosis phosphopantetheine
adenylyltransferase (MtPPAT) enzyme. Ligand-Based Drug Design (LBDD) strategies
were also used for establishing Structure-Activity Relationships (SAR) and for optimizing the
structures. MtPPAT is important for the biosynthesis of coenzyme A (CoA) and it has been studied
recently toward the discovery of new inhibitors.

Results:
After docking simulations and enthalpy calculations, the interaction of selected compounds
with MtPPAT was found to be energetically favorable. The most promising compounds were then
synthesized and submitted to anti-M. tuberculosis and MtPPAT inhibition assays.

Conclusion:
One of the compounds synthesized (MCP163), showed the highest activity in both of
these assays.