bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of FKBP5 gene variants with depression susceptibility: A comprehensive meta‐analysis
Authors: Fan Beifang , Ma Jianping , Zhang Huimin , Liao Yuhua , Wang Wanxin , Zhang Sheng , Lu Ciyong , Guo Lan 
Published: March 2021

AbstractBackgroundThis comprehensive meta‐analysis aimed to combine data from different studies and to estimate the association between FKBP5 polymorphisms and depression.MethodsWe performed a meta‐analysis of observational studies. An electronic search was conducted on four databases for articles published before July 1, 2020.ResultsA total of 5125 patients with depression and 8399 controls from 16 independent studies were included in the analysis. The results showed that FKBP5 rs1360780 was associated with the risk of depression in the codominant model (CT vs. CC; OR = 1.10, 95% CI = 1.00–1.20, P = .04); rs4713916 polymorphism was associated with depression in the codominant model (AG vs. GG; OR = 1.19, 95% CI = 1.05–1.34, P = .008) and recessive model (AA vs. AG + GG; OR = 0.74, 95% CI = 0.56–0.99, P = .04); a significant association between rs3800373 and depression was found in the codominant genetic model (AC vs. AA; OR = 1.18, 95% CI = 1.05–1.34, P = .007) and dominant model (CC + AC vs. AA; OR = 1.15, 95% CI = 1.03–1.30, P = .02); there was no significant association of FKBP5 rs9470080 or rs9296158 with depression in any genetic model (P > .05). No publication bias was observed in our analysis. Moreover, sensitivity analyses demonstrated the Zobel's study significantly affected the heterogeneity for rs4713916 and rs3800373.ConclusionsFKBP5 rs1360780 was associated with an increased risk of depression in the codominant model. We also found that rs4713916 and rs3800373 were involved in depression, rs4713916 was positively associated with depression in the codominant model and recessive model, and rs3800373 was related to an elevated risk of depression in the codominant model and dominant model.
Relationships matter! — Utilising ethics of care to understand transitions in the lives of adults with severe intellectual disabilities
Authors: Jacobs Paula , Quayle Ethel , Wilkinson Heather , MacMahon Ken 
Published: March 2021

Accessible summaryPeople with severe and profound intellectual disabilities need others to support them in most areas of their life. It can be difficult to communicate with people about change and transitions have been identified as an area of concern.As part of this research, we spent time with six adults with severe and profound intellectual disabilities. We talked to their families and professionals about their transitions and how they were involved in decisions that were made.Relationships people had with family members and key staff facilitated their engagement and experiences of the world.Our findings show that it is important that those who know the person well are closely involved in the planning of transitions. There should be a greater focus on maintaining the relationships that people have so that we can build bridges between settings and improve transitions for people with intellectual disabilities.AbstractBackgroundWithin the current literature, there is a focus on early transition experiences, such as people's school years, while adulthood remains a lesser researched chapter in the lives of people with intellectual disabilities. Furthermore, most studies focus on those with mild or moderate intellectual disabilities and people with severe or profound intellectual disabilities are often excluded from research.MethodsThis article explores the transition journeys of six adults with severe intellectual disabilities, including transitions from school to adult services and moving out of the family home. Data collection involved observations, document reviews and interviews with families and professionals in Scotland. Taking an ethics of care perspective, our focus was to explore in how far each person had people in their lives able to listen to them and if, in turn, those close to them were listened to during times of transition.FindingsOur findings demonstrate that transitions are complex processes that occur across different systems. Additionally, our findings emphasise the importance to consider relationships that are available to people within their adult lives when planning and supporting transitions. Combining interviews with observations helped us to see how the six adults showed agency and were communicating their preferences through the relationships they had with people within their immediate environment.ConclusionsThe need to reconceptualise participation from a relational and interdependent perspective is stressed to facilitate the involvement of people with severe intellectual disabilities within decision‐making processes.
Antibody‐drug conjugate MORAb‐202 exhibits long‐lasting antitumor efficacy in TNBC PDx models
Authors: Furuuchi Keiji , Rybinski Katherine , Fulmer James , Moriyama Tomoyuki , Drozdowski Brian , Soto Allis , Fernando Shawn , Wilson Kerrianne , Milinichik Andrew , Dula Mary Lou , Tanaka Keigo , Cheng Xin , Albone Earl , Uenaka Toshimitsu 
Published: March 2021

AbstractThe antibody‐drug conjugate (ADC) MORAb‐202, consisting of farletuzumab paired with a cathepsin B–cleavable linker and eribulin, targets folate receptor alpha (FRA), which is frequently overexpressed in various tumor types. MORAb‐202 was highly cytotoxic to FRA‐positive cells in vitro, with limited off‐target killing of FRA‐negative cells. Furthermore, MORAb‐202 showed a clear in vitro bystander cytotoxic effect in coculture with FRA‐positive/negative cells. In vivo antitumor efficacy studies of MORAb‐202 were conducted with a single administration of MORAb‐202 in triple‐negative breast cancer (TNBC) patient–derived xenograft (PDx) models expressing low and high levels of FRA. MORAb‐202 exhibited durable efficacy proportional to tumor FRA expression. Toxicology studies (Q3Wx2) in nonhuman primates suggested that the major observed toxicity of MORAb‐202 is hematologic toxicity. Overall, these findings support the concept that MORAb‐202 represents a promising investigational ADC for the treatment of TNBC patients.
Designing a leucine‐rich antibacterial nonapeptide with potent activity against mupirocin‐resistant MRSA via a structure–activity relationship study
Authors: Ang Qi An , Arfan Giovinna , Ong Chu Yang Fann , Ng Fui Mee , Ong Esther H. Q. , Chia Cheng San Brian 
Published: March 2021

AbstractStaphylococcus aureus is the main aetiological agent responsible for the majority of human skin infections. Of particular concern is the methicillin‐resistant variety, commonly known as MRSA. The extensive use of the first‐line topical antibiotic of choice, mupirocin, has inevitably resulted in the emergence of resistant strains, signalling an urgent need for the development of new antibacterials with new mechanisms of action. In this work, we describe how we designed a novel cationic nonapeptide, containing only leucine and two lysine residues, with potent anti‐MRSA activity and a rapid bactericidal mode of action. Coupled to a favourable safety profile towards human skin fibroblasts, we believe nonapeptide 11 has high potential for further development as a mupirocin replacement candidate to treat skin infections caused by MRSA.
A Developmental Hierarchical‐Integrative Perspective on the Emergence of Self‐Regulation: A Replication and Extension
Authors: Wu Qiong , Yan Jia , Cui Ming 
Published: March 2021

This study replicated and extended the Feldman (2009) study by applying the developmental hierarchical‐integrative model to understand the emergence of self‐regulation. Participants included 360 children (48.6% boys; 62.8% identified as Caucasian and 36.9% African American) and their families, predominantly from a low‐income, rural background. Families completed assessments on child physiological, attention, emotion, and self‐regulation when children were 6‐, 15‐, 24‐, and 36‐month‐old, when caregiver sensitivity was observationally assessed. A path model revealed that child attention regulation at 6 months predicted physiological regulation at 15 months, and child attention regulation at 15 months predicted emotion regulation at 24 months. Attention regulation at 24 months predicted better self‐regulation at 36 months. Notably, caregiver sensitivity moderated several developmental pathways. Findings support a continuous model of early self‐regulation development and the ongoing individual‐environment interplay in early childhood.
Chyme reinfusion nutritional management for enterocutaneous fistula: first international application of a novel pump technique
Authors: Solis Edgardo , Wright Danette B. , O’Grady Greg , Ctercteko Grahame 
Published: March 2021

AbstractAimHigh‐output enterocutaneous fistulas (ECFs) are an established cause of intestinal failure. Parenteral nutrition (PN) remains the gold standard for nutritional management but is complex, expensive and associated with significant complications. Chyme reinfusion (CR) has been reported by multiple centres as a viable option for nutritional management that improves nutritional status, provides the capacity to cease PN and is cost‐effective. The aim of this paper is to describe the first use of a novel pump device (The Insides System™) by an independent centre in Australia for the nutritional management of a patient with high‐output ECF.MethodCR was performed on a 66‐year‐old woman with a high‐output ECF. The device consists of two main components: a centrifugal pump that sits inside the stoma appliance and a battery‐powered driver that is magnetically coupled externally onto the pump. The device allows for bolus CR at a rate of infusion that is manually controlled by the patient based on comfort, volume and effluent viscosity.ResultsCR provided adequate nutritional support, with successful cessation of PN. Effective use of the device was learnt easily by the patient with minimal demands on nursing assistance. Side effects of CR (diarrhoea, abdominal cramping) were overcome by the patient's ability to manually adjust the reinfusion rate.ConclusionOur experience with the novel Insides System™ device showed promising results in maintaining nutritional status as well as providing a minimally invasive, easy to use and low‐cost system for CR. CR should be considered as a viable alternative for the nutritional management of patients with a high‐output ECF.
Internal and external barriers to entrepreneurship in Saudi Arabia
Authors: Abdulghaffar Nadia A. , Akkad Ghadeer Siraj 
Published: March 2021

AbstractIn many large and fast‐growing economies, entrepreneurship is widely promoted among the youth. Recent studies show an increased youth interest in entrepreneurship, resulting in decreased unemployment. Following the announcement of the Saudi Vision 2030, the government of Saudi Arabia has undertaken policies to boost interest in entrepreneurship. This study aims to analyze the internal (personality) and external (business environments) barriers to an entrepreneurial attitude in Saudi Arabia and further identify the factors behind the slow entrepreneurial growth in the Kingdom. Based on the theory of planned behavior and institutional economic theory, a conceptual model is developed. Findings of the study indicate a significant positive impact of personality traits, entrepreneurial education and competency, formal and informal support, and financial support on entrepreneurial attitude, while regulations have a negative impact on entrepreneurial attitude. Therefore, it can be concluded that individual personality traits—followed by business environment—are significant role factors in molding an entrepreneurial attitude.
Pattern of macrovascular invasion in hepatocellular carcinoma
Authors: Guarino Maria , Cucchetti Alessandro , Pontillo Giuseppina , Farinati Fabio , Benevento Francesca , Rapaccini Gian Ludovico , Di Marco Maria , Caturelli Eugenio , Zoli Marco , Rodolfo Sacco , Cabibbo Giuseppe , Marra Fabio , Mega Andrea , Gasbarrini Antonio , Svegliati‐Baroni Gianluca , Foschi Francesco Giuseppe , Missale Gabriele , Masotto Alberto , Nardone Gerardo , Raimondo Giovanni , Azzaroli Francesco , Vidili Gianpaolo , Oliveri Filippo , Trevisani Franco , Giannini Edoardo G. , Morisco Filomena ,   ITA.LI.CA Group
Published: March 2021

AbstractBackground and aimsIn patients with hepatocellular carcinoma (HCC), macrovascular invasion (MaVI) limits treatment options and decreases survival. Detailed data on the relationship between MaVI extension and patients' characteristics, and its impact on patients' outcome are limited. We evaluated the prevalence and extension of MaVI in a large cohort of consecutive HCC patients, analysing its association with liver disease and tumour characteristics, as well as with treatments performed and patients' survival.MethodsWe analysed data of 4774 patients diagnosed with HCC recorded in the Italian Liver Cancer (ITA.LI.CA) database (2008‐2018). Recursive partition analysis (RPA) was performed to evaluate interactions between MaVI, clinical variables and treatment, exploring the inter‐relationship determining overall survival.ResultsMaVI prevalence was 11.1%, and median survival of these patients was 6.0 months (95% CI, 5.1‐7.1). MaVI was associated with younger age at diagnosis, presence of symptoms, worse Performance Status (PS) and liver function, high alphafetoprotein levels and large HCCs. MaVI extension was associated with worse PS, ascites and greater impairment in liver function. RPA identified patients' categories with different treatment indications and survival, ranging from 2.4 months in those with PS > 1 and ascites, regardless of MaVI extension (receiving best supportive care in 90.3% of cases), to 14.1 months in patients with PS 0‐1, no ascites and Vp1‐Vp2 MaVI (treated with surgery in 19.1% of cases).ConclusionsMaVI presence and extension, together with PS and ascites, significantly affect patients' survival and treatment selection. The decision tree based on these parameters may help assess patients' prognosis and inform therapeutic decisions.
Recreational angler satisfaction: What drives it?
Authors: Birdsong Max , Hunt Len M. , Arlinghaus Robert 
Published: March 2021

AbstractSatisfaction is the reward that recreational anglers receive from their experiences, and it constitutes a relevant management target. Angler satisfaction also shapes preferences for regulations, compliance with rules and general angler behaviours. Because of its central role in recreational fisheries management, it is important to understand what drives angler satisfaction. Our objective was to study the catch and non‐catch‐related determinants of recreational angler satisfaction using a standardized literature search and synthesizing the literature using meta‐analytical techniques. After identifying and screening 279 papers, we obtained K = 172 effect sizes extracted from N = 23 studies that met our inclusion criteria. A three‐level random‐effects model on Pearson's R, derived from studies relating component satisfaction to overall satisfaction assuming a sum‐of‐satisfaction model, was fitted. The aggregated effect sizes revealed that catch‐related (i.e. catch rate, size of caught fish, fish harvest) and two non‐catch‐related components (i.e. access to fishing sites and crowding) were most related to angler satisfaction. Other non‐catch components (e.g. environmental quality, facilities, perception of relaxation quality) also contributed to angler satisfaction but were of less importance, more variable across studies and in some cases not significant (e.g. perceived water quality, quality of social experience). We conclude changes to access to fishing sites, crowding and a reduction in catch qualities, will in many cases produce dissatisfied anglers. In the absence of local studies, focusing management attention on these components can be recommended if the aim is to satisfy anglers or avoid managerial or social issues that emerge from dissatisfied anglers.
Fine‐scale mapping of deep‐sea habitat‐forming species densities reveals taxonomic specific environmental drivers
Authors: Dijkstra Jennifer A. , Mello Kristen , Sowers Derek , Malik Mashkoor , Watling Les , Mayer Larry A. 
Published: March 2021

AbstractAimEnvironmental variables are strongly tied to species occurrence and population growth, but approaches to predicting the location of deep‐sea species or their ability to withstand a changing environment stem primarily from presence data. We coupled environmental data with observed densities of deep‐sea habitat‐forming corals and sponges to determine the environmental variables and geomorphology that contributed best to their occurrence.LocationNorthwest Atlantic.Time period2013 and 2014.Major taxa studiedDeep‐sea coral and sponge communities.MethodsMultivariate and univariate analyses were used to determine significant environmental contributors to densities of genera and families of corals and sponges. We then assessed the relationship of densities of genera and families of corals and sponges with environmental variables found to be significant contributors to their occurrence and to geomorphology.ResultsSponge and coral genera and families were influenced by different environment variables. Temperature, salinity and dissolved oxygen contributed to the occurrence of sponges, whereas seafloor properties of slope and substrate contributed to the occurrence of corals. Although individuals of corals and sponges were observed across a range of a contributing environmental variable, high densities were observed only in very narrow ranges.Main conclusionsGeomorphic setting is an effective approach for discerning the associations of coral with seabed features. High densities of coral and sponge genera and families restricted to narrow environmental ranges might be at greater risk of local extinction. Differences in the occurrence of coral and sponge genera and families with environmental conditions suggest that they will differentially respond to predicted environmental changes. As conditions in the deep sea change with ongoing changes in climate, population expansion might be limited owing to suboptimal conditions, and established populations might persist but might have fewer individuals or species, which might lead to a loss in biodiversity.
The association between inflammatory bowel disease and migraine or severe headache among US adults: Findings from the National Health Interview Survey, 2015‐2016
Authors: Liu Yong , Xu Fang , Wheaton Anne G. , Greenlund Kurt J. , Thomas Craig W. 
Published: March 2021

AbstractObjectiveTo assess the prevalence of migraine or severe headache among US adults by inflammatory bowel disease (IBD) status.BackgroundEmerging evidence in clinical settings suggests a higher prevalence of migraine among patients with IBD than those without IBD.MethodsData from 60,436 US adults aged ≥18 years participating in the 2015 and 2016 National Health Interview Survey (NHIS) were analyzed. The relationship between IBD status and migraine or severe headache was assessed overall and stratified by levels of selected characteristics including sex, age, race/ethnicity, education, poverty status, marital status, smoking status, obesity status, serious psychological distress, and major chronic condition status.ResultsOverall, the age‐adjusted prevalence of migraine or severe headache was 15.4% (n = 9062) and of IBD was 1.2% (n = 862). A higher age‐adjusted migraine or severe headache prevalence was reported among participants with IBD than those without IBD (28.1% vs. 15.2%, p < 0.0001). The association of migraine or severe headache with IBD remained significant overall [adjusted prevalence ratio (95% CI) = 1.59 (1.35‐1.86)] and within the levels of most other selected characteristics after controlling for all other covariates.ConclusionsOur results confirmed a higher prevalence of migraine or severe headache among US adults with IBD than those without. Healthcare providers might assess migraine or severe headache among patients with IBD to improve management and quality of life.
A new technique in the treatment of ureteroenteric anastomosis stricture: Repair of ureteroenteric anastomosis stricture with low lombotomy incision (retroperitoneal approach)
Authors: Kalemci Serdar , Kizilay Fuat , Simsir Adnan 
Published: March 2021

AbstractIntroduction and aimUreteroenteric anastomosis stricture (UEAS) is one of the complications of urinary diversion and may lead to serious consequences. In this study, we evaluated our UEAS revision technique outcomes performed with a low lombotomy incision in the lateral decubitus position.Materials and methodsEleven patients who underwent surgical repair due to isolated right UEAS between January 2010 and June 2019 were included in the study. Anastomosis stricture was confirmed by ultrasonography, computed tomography or magnetic resonance urography techniques. Ultrasonography was used to detect hydronephrosis, which is a finding secondary to stricture. However, opaque urography imaging methods were used to confirm the definitive diagnosis of the stricture. Demographic and clinical data, preoperative and postoperative 3rd month serum creatinine, estimated glomerular filtration rate (eGFR) and dynamic renal scintigraphy data of patients were evaluated.ResultsThe mean operation time was 49.7 ± 9.3 minutes. No perioperative complications were observed. While the overall stricture rate was 11.4%, the isolated right‐sided stricture rate was 5.7%. Preoperative and postoperative serum creatinine values were similar. Preoperative eGFR value was 58.8 ± 12.9 mL/min/1.73 m2 and postoperative value was 53.5 ± 11.5 mL/min/1.73 m2. T½ level decreased in postoperative period (22.3 ± 8.2 min vs 15.1 ± 4.3 min).ConclusionsOpen revision of the UEAS with retroperitoneal approach provides lower morbidity rates and shorter hospitalisation time compared to other methods. The retroperitoneal approach is the main advantage of this technique and prevents morbidity caused by other techniques performed intraperitoneally and owing to it is an open technique, it can be easily applied in isolated right‐sided UEAS.
Seroprevalence of rubella virus among pregnant women: A 4‐year registered‐based study from family medicine and obstetric clinics in Saudi Arabia
Authors: AlShamlan Nouf A. , AlOmar Reem S. , AlOtaibi Amani S. , Almukhadhib Omar Y. , AlShamlan Abeer A. , Alreedy Abdullah H. , Zabeeri Najwa A. , Darwish Magdy A. , Al Shammri Malak A. 
Published: March 2021

AbstractObjectivesThis study aimed to determine rubella virus infectivity and immune status in pregnant females who visited the family medicine and obstetrics clinics at a large hospital in Saudi Arabia, and to identify the possible predictors of rubella susceptibility.MethodsThis registered‐based, cross‐sectional study included pregnant, aged between 18 and 50 years old, who presented for the first antenatal visit between 2017 and 2020. Data on sociodemographic, antenatal characteristics and serological results were collected. Chi‐Squared or Fisher's Exact test and t tests were used for bivariate analysis followed by the multivariable logistic regression model.ResultsA total of 4328 pregnant were included in the study. Seroprevalence of rubella immunity was 76.41%. Positive rubella IgM antibody was identified in 1.21% of those who performed the test (17/1409). Odds of susceptibility were decreased with an increase in age (OR = 0.96, 95% CI = 0.95‐0.97) and in non‐Saudis’ (OR = 0.44, 95% CI = 0.36‐0.54).ConclusionsApproximately 24% of pregnant were susceptible to rubella virus infections in this study. Screening females of child‐bearing age and reimmunisation of susceptible cases before pregnancy are suggested. Further studies to investigate the impact of applying this policy in premarital screening are recommended.