bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Immune-Related Analysis Based on Differentially Expressed Genes in Left- and Right-Sided Colon Adenocarcinoma
Authors: Guo Jun-Nan , Li Ming-Qi , Deng Shen-Hui , Chen Chen , Ni Yin , Cui Bin-Bin , Liu Yan-Long 
Published: March 2021

BackgroundColon adenocarcinoma (COAD) can be divided into left-sided and right-sided COAD (LCCs and RCCs, respectively). They have unique characteristics in various biological aspects, particularly immune invasion and prognosis. The purpose of our study was to develop a prognostic risk scoring model (PRSM) based on differentially expressed immune-related genes (IRGs) between LCCs and RCCs, therefore the prognostic key IRGs could be identified.MethodsThe gene sets and clinical information of COAD patients were derived from TCGA and GEO databases. The comparison of differentially expressed genes (DEGs) of LCCs and RCCs were conducted with appliance of “Limma” analysis. The establishment about co-expression modules of DEGs related with immune score was conducted by weighted gene co-expression network analysis (WGCNA). Furthermore, we screened the module genes and completed construction of gene pairs. The analysis of the prognosis and the establishment of PRSM were performed with univariate- and lasso-Cox regression. We employed the PRSM in the model group and verification group for the purpose of risk group assignment and PRSM accuracy verification. Finally, the identification of the prognostic key IRGs was guaranteed by the adoption of functional enrichment, “DisNor” and protein-protein interaction (PPI).ResultsA total of 215 genes were screened out by differential expression analysis and WGCNA. A PRSM with 16 immune-related gene pairs (IRGPs) was established upon the genes pairing. Furthermore, we confirmed that the risk score was an independent factor for survival by univariate- and multivariate-Cox regression. The prognosis of high-risk group in model group (P &lt; 0.001) and validation group (P = 0.014) was significantly worse than that in low-risk group. Treg cells (P &lt; 0.001) and macrophage M0 (P = 0.015) were highly expressed in the high-risk group. The functional analysis indicated that there was significant up-regulation with regard of lymphocyte and cytokine related terms in low-risk group. Finally, we identified five prognostic key IRGs associated with better prognosis through PPI and prognostic analysis, including IL2RB, TRIM22, CIITA, CXCL13, and CXCR6.ConclusionThrough the analysis and screening of the DEGs between LCCs and RCCs, we constructed a PRSM which could predicate prognosis of LCCs and RCCs, and five prognostic key IRGs were identified as well. Therefore, the basis for identifying the benefits of immunotherapy and immunomodulatory was built.
UGT1A1 rs4148323 A Allele is Associated With Increased 2-Hydroxy Atorvastatin Formation and Higher Death Risk in Chinese Patients With Coronary Artery Disease
Authors: Lei He-Ping , Qin Min , Cai Li-Yun , Wu Hong , Tang Lan , Liu Ju-E , Deng Chun-Yu , Liu Yi-Bin , Zhu Qian , Li Han-Ping , Hu Wei , Yang Min , Zhu Yi-Zhun , Zhong Shi-Long 
Published: March 2021

It is widely accepted that genetic polymorphisms impact atorvastatin (ATV) metabolism, clinical efficacy, and adverse events. The objectives of this study were to identify novel genetic variants influencing ATV metabolism and outcomes in Chinese patients with coronary artery disease (CAD). A total of 1079 CAD patients were enrolled and followed for 5 years. DNA from the blood and human liver tissue samples were genotyped using either Global Screening Array-24 v1.0 BeadChip or HumanOmniZhongHua-8 BeadChip. Concentrations of ATV and its metabolites in plasma and liver samples were determined using a verified ultra-performance liquid chromatography mass spectrometry (UPLC-MS/MS) method. The patients carrying A allele for the rs4148323 polymorphism (UGT1A1) showed an increase in 2-hydroxy ATV/ATV ratio (p = 1.69E−07, false discovery rate [FDR] = 8.66E−03) relative to the value in individuals without the variant allele. The result was further validated by an independent cohort comprising an additional 222 CAD patients (p = 1.08E−07). Moreover, the rs4148323 A allele was associated with an increased risk of death (hazard ratio [HR] 1.774; 95% confidence interval [CI], 1.031–3.052; p = 0.0198). In conclusion, our results suggested that the UGT1A1 rs4148323 A allele was associated with increased 2-hydroxy ATV formation and was a significant death risk factor in Chinese patients with CAD.
Synedrella nodiflora Extract Depresses Excitatory Synaptic Transmission and Chemically-Induced In Vitro Seizures in the Rat Hippocampus
Authors: Amoateng Patrick , Tagoe Thomas A. , Karikari Thomas K. , Kukuia Kennedy K. E , Osei-Safo Dorcas , Woode Eric , Frenguelli Bruno G. , Kombian Samuel B. 
Published: March 2021

Extracts of the tropical Cinderella plantSynedrella nodifloraare used traditionally to manage convulsive conditions in the West African sub-region. This study sought to determine the neuronal basis of the effectiveness of these plant extracts to suppress seizure activity. Using the hippocampal slice preparation from rats, the ability of the extract to depress excitatory synaptic transmission andin vitroseizure activity were investigated. Bath perfusion of the hydro-ethanolic extract ofSynedrella nodiflora(SNE) caused a concentration-dependent depression of evoked field excitatory postsynaptic potentials (fEPSPs) recorded extracellularly in the CA1 region of the hippocampus with maximal depression of about 80% and an estimated IC50of 0.06 mg/ml. The SNE-induced fEPSP depression was accompanied by an increase in paired pulse facilitation. The fEPSP depression only recovered partially after 20 min washing out. The effect of SNE was not stimulus dependent as it was present even in the absence of synaptic stimulation. Furthermore, it did not show desensitization as repeat application after 10 min washout produced the same level of fEPSP depression as the first application. The SNE effect on fEPSPs was not via adenosine release as it was neither blocked nor reversed by 8-CPT, an adenosine A1receptor antagonist. In addition, SNE depressedin vitroseizures induced by zero Mg2+and high K+-containing artificial cerebrospinal fluid (aCSF) in a concentration-dependent manner. The results show that SNE depresses fEPSPs and spontaneous bursting activity in hippocampal neurons that may underlie its ability to abort convulsive activity in persons with epilepsy.
Studying Music During the Coronavirus Pandemic: Conditions of Studying and Health-Related Challenges
Authors: Rosset Magdalena , Baumann Eva , Altenmüller Eckart 
Published: March 2021

ObjectiveThe coronavirus pandemic affects all areas of life. Performing arts and music studies have also experienced considerable changes, with university closures and a fluctuating return to normal and more limited operations. Prior studies detail the impact of the pandemic on college students, but we do not yet know what specific consequences it has for music students. The aim of this study is to examine the impact of the coronavirus pandemic on music students’ health, practicing behavior, and everyday life.MethodsIn July 2020, we conducted an online survey of 80 students enrolled in performance and music education programs at a German music university and compared these data with data from a survey of 75 students at the same music university carried out in summer 2019.ResultsThe survey revealed that the coronavirus pandemic led to a decrease in practicing hours and an increase of stressful thoughts and feelings. Students were mostly satisfied with Corona-measures taken by the university. Of analyzed determinants, only general fear of health problems was identified as a significant predictor of mental health status. Mental health status did not significantly differ between students surveyed in 2019 and 2020.ConclusionKnowledge about the specific challenges the pandemic poses for music students can help conservatories to better respond to the needs of their students. Specifically, this study will inform future measures supporting music students in coping with difficult situations like a pandemic.
Google Docs in Undergraduate online Composition Class: Investigating Learning Styles’ Impact on Writing Corrective Feedback
Authors: Zaky Hany 
Published: March 2021

Google Docs, as a collaborative online writing tool in Higher Education, facilitates and enhances the Composition pedagogical practices in face-to-face and virtual classes. The purpose of this quantitative study is to investigate the students’ learning styles’ impact on their Peer Assessment using Google Docs. Participants included 149 Composition students in a Public Health College of a private university in New York City.
The statistical findings of this study revealed that students’ learning skills in online writing classes could drive their perceptions of using Google Docs as a Peer Assessment Writing tool. These findings highlight the high correlation between students’ desire to interact after writing in English and their perceptions of using Google Docs as a collaborative writing tool. The findings also revealed statistically significant relationships between students’ perceptions of using Google Docs and their preferences of receiving feedback in different language areas. An increase in students’ perception of receiving feedback on their grammar, the flow of ideas, mechanics, quality of ideas, and Vocabulary, in that order, strongly led to an increase in their perceptions of using Google Docs. However, the findings indicate that there was no statistically significant linear relationship between students’ perceptions of their technical skills and their perceptions of using Google Docs in their online writing classes. Median Google Docs’s perceptions of males and females were not statistically different. There were no statistically significant differences in students’ Perceptions of Using Google Docs across the various age groups.
Determinación del nivel medio del mar en el mar de Bransfield. Aplicación a la determinación del geoide en islas Decepción y Livingston, Islas Shetland del Sur (Antártida)
Authors: Jigena Antelo Bismarck , Berrocoso Domínguez Manuel , Vidal Pérez Juan Manuel 
Published: March 2021

Este trabajo presenta un estudio detallado para la determinación del nivel medio del mar (NMM), las constituyentes de marea y un geoide de precisión en las islas Decepción y Livingston y el entorno del mar de Bransfield. Para realizar estos trabajos es necesario definir el marco de referencia geodésico, para ello se han utilizaron las redes geodésicas REGID (Red Geodésica de Isla Decepción), RENID (Red de Nivelación de Isla Decepción) y REGRID (Red Gravimétrica de Isla Decepción), utilizando como vértices fundamentales algunos puntos pertenecientes a la red RGAE (Red Geodésica Antártica Española). Los datos de marea fueron obtenidos mediante sensores de presión instalados en las estaciones mareográficas de LIVMAR y DECMAR, islas Livingston y Decepción respectivamente. Se obtuvieron las primeras series temporales con 798 días de observación en ambas estaciones, cuyo análisis armónico nos proporcionó 70 constituyentes de marea, siendo 19 las más representativas con amplitudes superiores a 1 cm. Se determinamos el nivel medio del mar, utilizando como puntos fundamentales el LN00 (I. Decepción) y BEJC (I. Livingston). Por último, se determinó el modelo de geoide de precisión, GeoiDEC14, calculado a partir de mediciones GPS, gravimétricas y de nivelación y cuyo resultado ha sido contrastado con los modelos globales más actuales. Estos son los primeros resultados de determinación del nivel medio del mar y la obtención de un modelo de geoide de precisión en esta zona de la Antártida y mejoran trabajos previos realizados en la región.
Moving sound source with an arbitrary trajectory in the two-dimensional finite-difference time-domain method
Authors: Tsuchiya Takao , Kanamori Masashi 
Published: March 2021

Abstract
In this paper, a moving sound source with an arbitrary trajectory is implemented using the finite-difference time-domain (FDTD) method. Two methods are proposed for implementing a moving-point sound source in the FDTD method, in which physically valid analysis is possible, including that of the Doppler effect. One method is the direct method and the other is the convolution method. We produce formulations and perform numerical experiments for a two-dimensional sound field, and the accuracies of the two proposed methods are compared. It is confirmed that both methods can be applied to a moving sound source, including the Doppler effect, and that the two methods have almost the same accuracy. It is found that the convolution method has advantages in that the source waveform and speed of movement can be freely changed at the time of convolution.
Over dosing trend of insecticides for sucking pest management in cotton in west Madhya Pradesh
Authors: Singh S. B. , Choudhary R. K. , Siddiqui A. 
Published: March 2021

The study was undertaken during 2011 and 2012 in five tehsils of Nimar region (West Madhya Pradesh) around the Narmada river, namely-Sanawad, Badwani, Khargone, Maheshwar and Dhamnod to know the over dosing trend and adverse effect of insecticides against sucking insect pest of cotton. In each location ten farms of different categories were selected based on acre age as F-1(up to 02 acres), F-2 (up to 04 acres), F-3 (up to 06 acres), F-4 (up to 08 acres), F-5 (up to 10 acres), F-6 (up to 12 acres), F-7 (up to 14 acres), F-8 (up to 16 acres), F-9 (up to 18 acres) and F-10 (More than 18 acres). All the information about insecticidal applications was received through discussion with farmers. The received information by each farmer of same category of ten locations about applied dose of insecticides and per cent reduction in insect population in each spray was averaged. The averaged data about insecticidal dose was converted into per cent increase over recommended dose of each insecticide and tabulated. The higher dose of acetamiprid 20 SP imidacloprid 17.8 SL, thiamethoxam 25WG, monocrotophos 36 SL, thiacloprid 21.7 SC and diafenthiuron 50WP was 36.01,45.89%, 64.61%, 72.10%, 79.24% and 85.60% in first, second, third, fourth, fifth and last spray, respectively. The reduction in insect pests population was found 55.40-72.40%, 52.50-60.50% , 51.25-58.25% 57.20-66.65% 50.75-63.25% and 55.40-68.25%% in first, second, third, fourth, fifth and last spray, respectively and overall averaged as 57.76-62.22%. From all the observations it was concluded that the application of higher dose of any insecticide did not reduce the sucking pest population much more than the recommended dose.
Data science and analytics in agricultural development
Authors: Sidhu Karamveer Singh , Singh Ramandeep , Singh Snehdeep , Singh Gunjot 
Published: March 2021

The consistent advancement of innovation has implied information and data being created at a rate, not at all like ever previously, and it's just on the ascent. The world makes an extra 2.5 quintillion bytes of information every year. The demand for individuals talented in investigating, deciphering, and utilising this information is now high and is set to become exponential over the coming years. The total populace is relied upon to arrive at 9.7 billion by 2050 from the current population of 7.8 billion. The Food and Agriculture Organization (FAO) has predicted that the development of farming must be expanded by 70% to provide for the extended interest. Data-driven agriculture choices can be a potent technology to manage the needs of this much high population, as this technology gives higher efficiency, rehearses support-ability, and even assists with giving straightforwardness to purchasers and consumers needing to find out about their food as reported in the studies. The current and future interests will require more data researchers, data engineers, data specialists, and chief data Officers. This paper tries to examine the need, use, role, and issues faced by data science and data analytics to improve the quality as well as quantity of Agricultural produce thereby leading to an increase in production, a decrease in costs, and overall sustainability.
Economic analysis of green fodder crops for enhancing the dairy profitability in Punjab
Authors: Singh Varinder Pal , Singh Harparteet , Kaur Inderpreet 
Published: March 2021

The present study has been carried out in three agro-climatic regions of Punjab state, i.e. Sub mountainous, Central and South-Western regions for examining the economics of different green fodder crops and importance of green fodder in enhancing the dairy profitability. The study consisted of a total sample size of 120 farmers growing green fodder crops and keeping dairy animals. It was observed from the study that the profitability from important green fodder crops based crop cycle is a little bit higher (bajra + berseem ` Rs.1,213) than the traditional wheat-paddy crop rotation (`Rs.49,005). It was found that proportion of green fodder in the cost of milk production was lower (12.12 per cent) if green fodder is home-produced compared to the market prices of green fodder (23.13 per cent). In this way, the expenditure on green fodder can be curtailed by about 13-14 per cent, which will curtail the overall cost of production of milk and enhance the productivity and profitability from milk production. A direct link between green fodder quantity and milk yield has been observed. Therefore, farmers need to motivated for enhancing the green fodder production for properly feeding the animals and further, they should try to increase the herd size so that higher profits from dairy farming can be realized.
Formación, actualización y perfeccionamiento profesional en matemáticas modernas para docentes de la etapa primaria de educación básica general
Authors: Peralta Moreno Martín Alexis 
Published: March 2021

La investigación se centró en describir las concepciones que tienen los maestros sobre las matemáticas modernas, su enseñanza y aprendizaje y, más concretamente, sobre su formación profesional en matemáticas, así como el conocimiento que poseen de las diferentes áreas que tienen que desarrollar según el programa del Ministerio de Educación. A partir de los datos suministrados por el diagnóstico y los análisis respectivos se diseñó una propuesta de formación, actualización y perfeccionamiento profesional en docentes de matemáticas modernas de la primera etapa de educación básica general, la cual se implementó y validó en escuelas de la comunidad de Betania, Distrito de Panamá. Se tomaron como informantes clave 8 docentes del área de matemática. El estudio se desarrolló bajo el enfoque cualitativo, a través del método hermenéutico interpretativo. La recolección de los datos se realizó a través de la técnica de la entrevista y la observación complementando con un análisis documental. Los resultados de este estudio revelaron que el conocimiento matemático de los maestros está circunscrito a las operaciones básicas con números naturales, influenciado por su concepción hacia la matemática clásica y la formación que recibió como estudiante de la licenciatura en educación. Se encontró que se utiliza un repertorio reducido de estrategias y técnicas para la enseñanza de las diferentes áreas de las matemáticas modernas. Esto es atribuible tanto a la formación profesional de cada docente como al currículo escolar cuyos nuevos contenidos, implantados por la llamada transformación curricular, los cuales no son de dominio explícito de los educadores que laboran en la educación primaria del nivel de premedia. A partir de este diagnóstico se diseñó, implementó y evaluó un programa de formación, actualización y perfeccionamiento para docentes de primaria con enfoques diferentes a los actuales, a la luz de las matemáticas modernas, centrados en cada una de las áreas establecidas en el programa curricular del Ministerio de Educación.
Directivos docentes resilientes
Authors: Franco Amado Luz Dary 
Published: March 2021

En toda Institución Educativa la gestión directiva, académica, administrativa y comunitaria recae directamente en el equipo de Directivos Docentes, en calidad de rectores o coordinadores. Ante esta gran responsabilidad se hace necesario diseñar una Propuesta de Gestión Directiva Resiliente que facilite la eficacia y la eficiencia en su desempeño laboral. El presente artículo informa sobre los avances obtenidos en la investigación, originada dentro del marco del Programa de Doctorado en la Universidad Metropolitana de Ciencia y Tecnología, UMECIT, titulada “Directivos docentes resilientes, una propuesta para enfrentar la realidad educativa al interior de las instituciones educativas oficiales del municipio de Bucaramanga, Colombia”. Para dar cuenta de la investigación en curso se aborda en primera instancia los objetivos rectores de la investigación. Se presenta de manera sucinta la fundamentación teórica sobre los modelos de gestión directiva a nivel internacional, regional y local y la resiliencia como eje articulador de las competencias funcionales y comportamentales. Seguidamente se expone la metodología seleccionada para direccionar el proceso investigativo. Luego se muestran los principales resultados obtenidos con su correspondiente discusión e interpretación en función de los objetivos específicos. Por último las consideraciones finales a tener en cuenta en la estructuración del producto final de la investigación.
Pendidikan Karakter pada Kumpulan Esai “Men Coblong” Karya Oka Rusmini
Authors: Sari Dina Purnama 
Published: March 2021

<p>“Men Coblong” are 58’s of manuscript essays written by Oka Rusmini in the Bali Post and continued on balebengong.id with various themes. The purpose of this research is to find out the moral messages related to the phenomenon of education in Indonesia which is experienced by the character based on the 3 selected essays. The method chosen is a study of literary phenomenology with a character education approach. The result is that there is character education based on the phenomena experienced by the character in relation to honesty, tolerance, and family education. The research implication is that the reader takes the implicit moral based on the character's experience.</p><p>“Men Coblong” merupakan naskah 58 esai yang ditulis Oka Rusmini di Bali Post dan dilanjutkan di balebengong.id dengan tema yang beragam. Tujuan penelitiannya adalah untuk mengetahui pesan moral berkaitan dengan fenomena pendidikan di Indonesia yang dialami oleh sang tokoh berdasarkan 3 esai yang dipilih. Metode yang dipilih adalah kajian fenomenologi sastra dengan pendekatan pendidikan karakter. Hasilnya adalah terdapat pendidikan karakter berdasarkan fenomena yang dialami oleh sang tokoh berkaitan dengan kejujuran, toleransi, dan pendidikan keluarga. Implikasi penelitiannya adalah pembaca mengambil moral tersirat berdasarkan pengalaman sang tokoh.</p>