bluuebunny/crossref_metadata_2025_split huggingface dataset:
High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing
Authors: Kostecka Anna , Nowikiewicz Tomasz , Olszewski Paweł , Koczkowska Magdalena , Horbacz Monika , Heinzl Monika , Andreou Maria , Salazar Renato , Mair Theresa , Madanecki Piotr , Gucwa Magdalena , Davies Hanna , Skokowski Jarosław , Buckley Patrick G. , Pęksa Rafał , Śrutek Ewa , Szylberg Łukasz , Hartman Johan , Jankowski Michał , Zegarski Wojciech , Tiemann-Boege Irene , Dumanski Jan P. , Piotrowski Arkadiusz 
Published: September 2021

AbstractThe mammary gland undergoes hormonally stimulated cycles of proliferation, lactation and involution. We hypothesized that these factors increase the mutational burden in glandular tissue and may explain high cancer incidence rate in the general population and recurrent disease. Hence, we investigated the DNA sequence variants in the normal mammary gland, tumor and peripheral blood from 52 reportedly sporadic breast cancer patients, including breast-conserving surgery cases. Targeted resequencing of 542 cancer associated genes revealed mosaic somatic pathogenic variants of: PIK3CA, TP53, AKT1, MAP3K1, CDH1, RB1, NCOR1, MED12, CBFB, TBX3 and TSHR in the normal mammary gland, at considerable allelic frequencies (9×10−2 to 5.2×10−1) indicating clonal expansion. Further evaluation of the frequently damaged PIK3CA and TP53 genes by ultra-sensitive duplex sequencing demonstrated a diversified picture of multiple low level-mosaic (in 10−2 to 10−4 alleles) hotspot pathogenic variants. Our results raise a question about the oncogenic potential in non-tumor mammary gland tissue of breast-conserving surgery patients.
Consumer empowerment in corporate social responsibility: the effect of participatory CSR on company admiration and word-of-mouth communications
Authors: Park Hyojung , Kim Soo-Yeon 
Published: September 2021

PurposeThis study conceptualizes participatory corporate social responsibility (CSR) as a consumer empowerment strategy and examines the effect of participatory CSR on consumer responses in a social media setting.Design/methodology/approachThis study uses a 2 (type of CSR campaign) × 4 (tone of consumer comments) between-subjects experimental design. The sample comprises college students and nonstudent participants recruited from Amazon Mechanical Turk.FindingsData indicate that the participatory CSR program leads to higher levels of perceived self-efficacy and social worth, which subsequently results in stronger intentions to spread positive word of mouth about the company’s CSR efforts. The findings suggest that participatory CSR has the power to boost a company’s reputation as an “admired” company through consumer empowerment.Originality/valueThis study advances the scholarship of CSR by explicating participatory CSR communication as a consumer empowerment strategy and providing empirical evidence for the effect of participatory CSR on public responses. The overall findings support the notion that CSR communication as an important function of public relations can generate public engagement with the organization and further co-create meaning with publics for mutual benefit.
Predicting intention of business students to behave ethically in the Indian context: from the perspective of Theory of Planned Behaviour
Authors: Marmat Geeta 
Published: September 2021

PurposeThe purpose of this paper is to understand business students' intention to behave ethically in general, and in particularly in the business context of a developing country, India.Design/methodology/approachThe paper surveyed 250 final semester MBA students from different business schools in Indore city of Madhya Pradesh in India. The study employed the most popular behavioural theory, the Theory of Planned Behaviour (TPB) to understand the intention of business students to behave ethically. Structural equation modelling was used to analyse direct effects of the constructs on behavioural intention, and the overall model.FindingsFindings revealed that attitude, subjective norm and perceived behavioural control are positively related and have strong influence on ethical behavioural intention of business students. All constructs together explain 67 percent variance in intention. Attitude alone contributes 46 percent in explaining variance in ethical behavioural intention.Research limitations/implicationsBusiness ethics field can benefit from this study as it provides an empirical explanation of the contribution of each factor that is, attitude, subjective norms and perceived behavioural control, in ethical behavioural intention of business students. This is directly beneficial for business schools and for education policymakers as the information can help policymakers to understand the potential of existing business ethics education. This study is limited to a data set of 250 business students in the context of a single country which cannot be generalized. So, there is need for research of this type in a more collaborative international context.Originality/valueTo the best of my knowledge, this is the first study in the Indian context to predict the intention of business students to behave ethically, using the TPB model. This study contributes valuable knowledge to the domain of business ethics, behavioural studies as well the field of business education, and suggests to explore ways to strengthen the three constructs attitude, subjective norm and perceived behavioural control, as these constructs were found to have a strong influence in forming ethical behavioural intention of business students of business schools in India.
Multiphysics simulation of single pulse laser powder bed fusion: comparison of front capturing and front tracking methods
Authors: Mayi Yaasin Abraham , Queva Alexis , Dal Morgan , Guillemot Gildas , Metton Charlotte , Moriconi Clara , Peyre Patrice , Bellet Michel 
Published: September 2021

Purpose
During thermal laser processes, heat transfer and fluid flow in the melt pool are primary driven by complex physical phenomena that take place at liquid/vapor interface. Hence, the choice and setting of front description methods must be done carefully. Therefore, the purpose of this paper is to investigate to what extent front description methods may bias physical representativeness of numerical models of laser powder bed fusion (LPBF) process at melt pool scale.

Design/methodology/approach
Two multiphysical LPBF models are confronted: a Level-Set (LS) front capturing model based on a C++ code and a front tracking model, developed with COMSOL Multiphysics® and based on Arbitrary Lagrangian–Eulerian (ALE) method. To do so, two minimal test cases of increasing complexity are defined. They are simplified to the largest degree, but they integrate multiphysics phenomena that are still relevant to LPBF process.

Findings
LS and ALE methods provide very similar descriptions of thermo-hydrodynamic phenomena that occur during LPBF, providing LS interface thickness is correctly calibrated and laser heat source is implemented with a modified continuum surface force formulation. With these calibrations, thermal predictions are identical. However, the velocity field in the LS model is systematically underestimated compared to the ALE approach, but the consequences on the predicted melt pool dimensions are minor.

Originality/value
This study fulfils the need for comprehensive methodology bases for modeling and calibrating multiphysical models of LPBF at melt pool scale. This paper also provides with reference data that may be used by any researcher willing to verify their own numerical method.
Dual similarity solutions because of mixed convective flow of a double-nanoparticles hybrid nanofluid: critical points and stability analysis
Authors: Pop Ioan , Nademi Rostami Mohammadreza , Dinarvand Saeed 
Published: September 2021

Purpose
The purpose of this article is to study the steady laminar magnetohydrodynamics mixed convection stagnation-point flow of an alumina-graphene/water hybrid nanofluid with spherical nanoparticles over a vertical permeable plate with focus on dual similarity solutions.

Design/methodology/approach
The single-phase hybrid nanofluid modeling is based on nanoparticles and base fluid masses instead of volume fraction of first and second nanoparticles as inputs. After substituting pertinent similarity variables into the basic partial differential equations governing on the problem, the authors obtain a complicated system of nondimensional ordinary differential equations, which has non-unique solution in a certain range of the buoyancy parameter. It is worth mentioning that, the stability analysis of the solutions is also presented and it is shown that always the first solutions are stable and physically realizable.

Findings
It is proved that the magnetic parameter and the wall permeability parameter widen the range of the buoyancy parameter for which the solution exists; however, the opposite trend is valid for second nanoparticle mass. Besides, mass suction at the surface of the plate as well as magnetic parameter leads to reduce both hydrodynamic and thermal boundary layer thicknesses. Moreover, the assisting flow regime always has higher values of similarity skin friction and Nusselt number relative to opposing flow regime.

Originality/value
A novel mass-based model of the hybridity in nanofluids has been used to study the foregoing problem with focus on dual similarity solutions. The results of this paper are completely original and, to the best of the authors’ knowledge, the numerical results of the present paper were never published by any researcher.
Dynamic response and parameter analysis on the vehicle–bridge coupling of cable-stayed bridge under over-limit transportation
Authors: Lu Yao , Li Dejian , Wang Kai , Li Zhen 
Published: September 2021

PurposeOver-limit transportation has the characteristics of large axle load, large number of axles and lateral distribution width. Under the action of over-limit load, the coupling vibration effect of vehicle–bridge is more obvious, and the deformation of bridge components is large. Thus, research and analysis of the vehicle–bridge coupling dynamic response of long-span bridges under over-limit transportation has practical engineering significance.Design/methodology/approachBased on the principle of invariable elastic potential energy, this paper derives dynamic model of over-limit transportation n-axis flat vehicle. The numerical simulation method is used to model and calculate a cable-stayed bridge, and the static effect of the cable-stayed bridge and the dynamic response of vehicle–bridge coupling under different parameters are compared and analyzed.FindingsThe focus is on the influence of vehicle load and vehicle velocity parameters on the stress and amplitude of different cables under over-limit transportation, and the corresponding variation law is obtained.Originality/valueThe research on the coupled dynamic response of cable-stayed bridges has attracted the attention of many scholars, but there are relatively few studies on the coupled vibration of out-limit vehicles and bridges. In this paper, based on finite element software, a vehicle–bridge coupling model under bulk transportation is established.
Does bank governance affect risk and efficiency? Evidence from Islamic banks in GCC countries
Authors: Srairi Samir , Bourkhis Khawla , Houcine Asma 
Published: September 2021

Purpose
The motivation of the study is to shed further light on the question of whether the governance structure of Islamic banks (IBs) has an impact on the efficiency and risk of Islamic banks operating in the Gulf Cooperation Council (GCC) after the global financial crisis and during the period 2010–2018. This study aims to examine the extent of governance structure on the efficiency and risk of IBs as the effect of the financial crisis has been less on IBs. In addition, the authors are interested in the GCC region as it represents the hub of Islamic finance.

Design/methodology/approach
In this study, the authors examine how the banking governance structure affects the risk-taking and performance of IBs in the GCC countries between 2010 and 2018. The authors construct a banking governance index (CGI) composed of sub-indices for the board structure, risk management, transparency and disclosure, audit committee, Sharia supervisory board and investment account holders. Unlike the majority of previous studies, bank performance is measured with technical efficiency scores using a data envelopment analysis and the authors use a comprehensive CGI.

Findings
The results show that IBs in GCC countries adhere to 54% of the attributes covered in the CGI. The authors also note a lack of disclosure regarding the investment account holders and the audit committee. As well, the results indicate that bank governance is positively associated with risk-taking and bank efficiency. Banking risk is influenced by the Sharia board and risk management while bank efficiency is affected by the characteristics of the board structure and investment account holders.

Originality/value
To the best of the authors’ knowledge, this is the first study that has developed a comprehensive governance index for IBs in GCC countries that includes a wide range of governance dimensions. The study contributes to the literature on governance in the banking sector by simultaneously examining its impact on the risk-taking and efficiency of IBs and recognizes the dynamic relation between these three variables for IB.
Informal sellers and formal markets: a habitus gap
Authors: Pels Jaqueline , Araujo Luis , Kidd Tomas Andres 
Published: September 2021

Purpose
In developing economies, 30% of the gross domestic product on average is undertaken by unregistered businesses. The informal economy leads to high opportunity costs by preventing gains from trade with strangers. To overcome this obstacle, sellers who usually operate in the informal economy should strive to move to formal markets. Current theories are drawn from a view of markets as institutions governed by formal and informal rules. In a nutshell, informal-formal market transitions must be met with a regulative solution. However, the overall results have been disappointing. This failure invites a re-diagnosis of the problem that informal sellers face to act in formal markets and suggesting novel solutions. This paper aims to address this gap.

Design/methodology/approach
This is a conceptual paper. The authors adopt MacInnis’s (2011) framework to characterize the approach to theory development.

Findings
The authors argue that extant views of formal/informal markets differences address only one of Scott’s (2014) three pillars (regulative, normative and cultural-cognitive). By drawing on Bourdieu’s legacy, the authors propose a cultural-cognitive reading of institutions and suggest it offers a lens to understand the problem as an access challenge, and thus a marketing problem. This perspective allows us to conceptualize informal/formal markets as two distinct institutional fields and argues that all individuals inhabit a particular habitus and contend that moving between markets requires a habitus shift. Thus, acting in formal markets involves bridging a habitus gap. Finally, the authors argue the need for a market-facing intermediary that takes on a market habitus bridging role.

Research limitations/implications
The authors suggest future research efforts could benefit from this new conceptual lens as a means of re-diagnosing other forms of market access that have produced disappointing results.

Practical implications
By looking at differences between formal and informal markets as a habitus gap, the allocation of public funds to support transitions can be better targeted and spent.

Social implications
The concept of market-facing intermediaries suggests that the beneficiary (e.g. informal seller) and target populations can be different. This insight could catalyze social innovation and trigger novel perspectives to design systemic solutions.

Originality/value
Conceptualizing the formal-informal market transition as a habitus gap suggests new directions to resolve access challenges and a new mediator solution.
Empowering value co-creation in the digital age
Authors: Barile Sergio , Bassano Clara , Piciocchi Paolo , Saviano Marialuisa , Spohrer James Clinton 
Published: September 2021

Purpose
Technology is revolutionizing the management logic of service systems. The increasing use of artificial intelligence (AI), in particular, is challenging interaction between humans and machines changing the service systems’ value co-creation configurations and logic. To envision possible future scenarios, this paper aims to reflect upon how the humans’ use of AI technology can impact value co-creation.

Design/methodology/approach
The study is developed, at a conceptual level, using selected elements from managerial and marketing theoretical frameworks interested in value co-creation – Service-Dominant Logic, Service Science and Viable Systems Approach (VSA) – used as interpretative tools to reframe value co-creation in the digital age.

Findings
The interpretative approach adopted and, in particular, the new VSA notion of Intelligence Augmentation (IA), in the perspective of the information variety model, shed new light on value co-creation in the digital age framing a possible “IA effect” that can empower value co-creation in complex decision-making contexts.

Practical implications
The study provides insights useful in the design and management of service systems suggesting a rethinking of the view of AI as a means for mainly increasing the smartness of service systems and a new focus on the enhancement of the human resources contribution to make the service systems wiser.

Originality/value
The paper provides a refocused interpretative view of the interaction between humans and AI that looks at a possible positive impact of the use of AI on humans in terms of augmented decision-making capabilities in conditions of complexity.
A review on the performance characteristics, applications, challenges and possible solutions in electron beam melted Ti-based orthopaedic and orthodontic implants
Authors: Ishfaq Kashif , Rehman Mudassar , Khan Ahmed Raza , Wang Yanen 
Published: September 2021

PurposeHuman aging is becoming a common issue these days as it results in orthopaedic-related issues such as joints disorderness, bone-fracture. People with age = 60 years suffer more from these aforesaid issues. It is expected that these issues in human beings will ultimately reach 2.1 billion by 2050 worldwide. Furthermore, the increase in traffic accidents in young people throughout the world has significantly emerged the need for artificial implants. Their implantation can act as a substitute for fractured bones or disordered joints. Therefore, this study aims to focus on electron beam melted titanium (Ti)-based orthopaedic implants along with their recent trends in the field.Design/methodology/approachThe main contents of this work include the basic theme and background of the metal-based additive manufacturing, different implant materials specifically Ti alloys and their classification based on crystallographic transus temperature (includingα, metastableβ,βandα+βphases), details of electron beam melting (EBM) concerning its process physics, various control variables and performance characteristics of EBMed Ti alloys in orthopaedic and orthodontic implants, applications of EBMed Ti alloys in various load-bearing implants, different challenges associated with the EBMed Ti-based implants along with their possible solutions. Recent trends and shortfalls have also been described at the end.FindingsEBM is getting significant attention in medical implants because of its minor issues as compared to conventional fabrication practices such as Ti casting and possesses a significant research potential to fabricate various medical implants. The elastic modulus and strength of EBMed ß Ti-alloys such as 24Nb-4Zr-8Sn and Ti-33Nb-4Sn are superior compared to conventional Ti for orthopaedic implants. Beta Ti alloys processed by EBM have near bone elastic modulus (approximately 35–50 GPa) along with improved tribo-mechanical performance involving mechanical strength, wear and corrosion resistance, along with biocompatibility for implants.Originality/valueAdvances in EBM have opened the gateway Ti alloys in the biomedical field explicitlyß-alloys because of their unique biocompatibility, bioactivity along with improved tribo-mechanical performance. Less significant work is available on the EBM of Ti alloys in orthopaedic and orthodontic implants. This study is directed solely on the EBM of medical Ti alloys in medical sectors to explore their different aspects for future research opportunities.
QMS external quality auditors’ education framework: findings from an iterative Delphi study
Authors: Ab Wahid Roslina , Grigg Nigel Peter 
Published: September 2021

PurposeThe paper aims to describe the development of an open curriculum framework of external quality auditors (EQAs) education. The study was commissioned by accreditation body JAS-ANZ, with the objective of improving EQA audit performance, resulting in more effective audits that can add value to client organisations.Design/methodology/approachThe key sets of knowledge, skills and attributes that auditors should possess were identified from the literature and an initial survey, and validated through several rounds of experts' opinion using the Delphi technique. The Delphi panel consisted of: top managers; quality practitioners; academicians; quality auditors, consultants and managers; a financial auditor and other managers. Kendall's coefficient of concordance (Kendall's W) was used to measure the level of agreement of the experts' ranking scores.FindingsPanelists believed there is a need for EQAs to be more broadly grounded in certain knowledge, skills, and attributes. The knowledge requirements for EQAs were: audit principles, process and methods; quality management principles, system, and standards; risk management; business process and operations management; applicable legal, regulatory and contractual requirements; strategic planning; and performance measurement. EQAs need strong skills in communication, auditing, people relations, critical thinking, report writing, leadership, coaching and coordination. The attributes considered essential are objectivity, integrity, ethics and professionalism; being observant, perceptive, articulate and confident; having good judgement; being flexible, adaptive, diplomatic, fair and open-minded. Based on these outcomes, the curriculum framework of EQAs was developed.Originality/valueThis study highlights the core elements required in a syllabus to prepare EQAs for value-added auditing in the present and future. The educational framework can be adopted by accreditation and certification bodies to evaluate and improve their auditors' audit performance.