bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dealing with Uncertainties in Fatigue Strength Using Deep Rolling
Authors: Yüksel Berkay , Görtan Mehmet Okan 
Published: May 2021

AbstractMechanical properties inherently possess uncertainties. Among these properties, fatigue behavior data generally shows significant scatter which introduces a challenge in the safe design of dynamically loaded components. These uncertainties in fatigue behavior are mainly results of factors related to surface state including: Roughness, tensile residual stresses, scratches and notches at surface. Therefore, controlling these parameters allows one to increase fatigue strength and reduce scatter and uncertainties in fatigue behavior. Mechanical surface treatments are applied on parts to increase fatigue strength via introducing compressive residual stresses and work-hardening at surface. Two of the most common among these treatments are shot peening and deep rolling. Shot peening has found many applications in industry because of its flexibility. However, it introduces irregularities at the surface and may increase roughness which causes uncertainties in the fatigue behavior data; especially for low-medium strength materials. Unlike shot peening, deep rolling reduces surface roughness. Therefore, it has the capability to reduce uncertainty in the fatigue behavior. To this date, rolling direction of deep rolling was selected as tangential direction to turning direction for axisymmetric parts. Nonetheless, the authors believe that the rolling direction has an apparent effect on the fatigue behavior. In this study, longitudinal direction was also applied for deep rolling operation and the results of these two direction applications on the EN-AW-6082 aluminum alloy were investigated. It was shown that, longitudinal rolling had yielded less scatter and uncertainty in the fatigue behavior than the tangential rolling together with the higher fatigue strength.
RiskStructures
: A design algebra for risk-aware machines
Authors: Gleirscher Mario , Calinescu Radu , Woodcock Jim 
Published: May 2021

Abstract

Machines, such as mobile robots and delivery drones, incorporate controllers responsible for a task while
handling risk
(e.g. anticipating and mitigating hazards; preventing and alleviating accidents). We refer to machines with this capability as risk-awaremachines.
Risk awareness
includes robustness and resilience and complicates monitoring (i.e., introspection, sensing, prediction), decision making, and control. From an engineering perspective, risk awareness adds a range of dependability requirements to
system assurance
. Such assurance mandates a correct-by-construction approach to controller design, based on mathematical theory.We introduce RiskStructures, an algebraic framework for risk modelling intended to support the design of
safety controllers
for risk-aware machines. Using the concept of a
risk factor
as a modelling primitive, this framework provides facilities to construct, examine, and assure these controllers.We prove desirable algebraic properties of these facilities, and demonstrate their applicability by using them to specify key aspects of safety controllers for risk-aware automated driving and collaborative robots.
Enhancing Probabilistic Model Checking with Ontologies
Authors: Dubslaff Clemens , Koopmann Patrick , Turhan Anni-Yasmin 
Published: May 2021

AbstractProbabilistic model checking (PMC) is a well-established method for the quantitative analysis of state based operational models such as Markov decision processes. Description logics (DLs) provide a well-suited formalism to describe and reason about knowledge and are used as basis for the web ontology language (OWL). We investigate how such knowledge described by DLs can be integrated into the PMC process, introducingontology-mediatedPMC. Specifically, we proposeontologized programsas a formalism that links ontologies to behaviors specified by probabilistic guarded commands, the de-facto standard input formalism for PMC tools such as Prism. Through DL reasoning, inconsistent states in the modeled system can be detected. We present three ways to resolve these inconsistencies, leading to different Markov decision process semantics. We analyze the computational complexity of checking whether an ontologized program is consistent under these semantics. Further, we present and implement a technique for the quantitative analysis of ontologized programs relying on standard DL reasoning and PMC tools. This way, we enable the application of PMC techniques to analyze knowledge-intensive systems.We evaluate our approach and implementation on amulti-server systemcase study,where different DL ontologies are used to provide specifications of different server platforms and situations the system is executed in.
“To be or not to be” located in a cluster?—A descriptive meta-analysis of the firm-specific cluster effect
Authors: Grashof Nils , Fornahl Dirk 
Published: May 2021

AbstractIn the twenty-first century, clusters can be observed in most developed economies. However, the scientific results regarding the effect of clusters on firm performance are highly contradictive. The inconsistencies in the empirical results make it difficult to infer general conclusions about the firm-specific cluster effect, or in other words, the effect from being located in a cluster on firm performance (e.g. derived through the externalities within clusters). Therefore, this paper aims to reconcile the contradictory empirical findings. It investigates whether the prevalent assumption that clusters are a beneficial location for firms is unconditionally true or whether doubts about the alleged positive effect of clusters on firm performance are justified. By conducting a descriptive meta-analysis of the empirical literature, based on four different performance variables from four separate publication databases, the study investigates the direction of the effect as well as possible moderating influences. We find evidence for a rather positive firm-specific cluster effect. However, we identify several variables from the micro-, meso- and macro-level that directly or interactively moderate the relationship between clusters and firm success. For example, the results demonstrate that a negative firm-specific cluster effect occurs more frequently in low-tech industries than in high-tech industries. “To be or not to be” located in a cluster is therefore not the question, but it rather depends on the specific conditions.
Financial stability and local economic development: the experience of Italian labour market areas
Authors: Barra Cristian , Zotti Roberto 
Published: May 2021

AbstractRegulators should ensure the smooth functioning of the system and promote regional development. Making the health of financial institutions is therefore a prerequisite for a sustainable economic development. This paper contributes to the literature on the relationship between the financial stability and growth within the area of one country. This implies that institutional, legal, and cultural factors are more adequately controlled for and financial markets are more accurately bounded. Using a rich sample of Italian banks over the 2001–2012 period, this paper addresses whether different measures of financial distress affect economic development of labour market areas in Italy. Results show that the financial stability has a positive effect on local economic development, robust to alternative variables capturing financial vulnerability. The presence of spatial effects is tested showing that better financial conditions of the banking system in neighbouring areas have a detrimental effect on an area’s growth.
Investigation of different dietary-fibre-ingredients for the design of a fibre enriched bread formulation low in FODMAPs based on wheat starch and vital gluten
Authors: Atzler Jonas J. , Sahin Aylin W. , Gallagher Eimear , Zannini Emanuele , Arendt Elke K. 
Published: May 2021

AbstractConsumption of fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) often induces symptoms of irritable bowel syndrome (IBS). Since FODMAPs and dietary fibre (DF) share certain characteristics, IBS-patients have a limited intake of DF. Therefore, enrichment of a low FODMAP model bread (based on 84% wheat starch and 16% vital gluten) with various fibres (bamboo, cellulose, psyllium, guar gum) in two different concentrations (3 g/100 g and 6 g/100 g) was investigated. Physico-chemical properties of doughs and breads were analysed (fermentation quality, gluten development, specific volume and hardness), as well as the release of reducing sugars during in vitro digestion. High performance anion exchange chromatography with coupled pulsed amperometric detection (HPAEC-PAD) was used to determine the FODMAP levels (contents of mannitol, sorbitol, fructose in excess of glucose, fructans and α-galactooligosaccharides) of both dough and bread. Prototypes were compared with wheat flour-based breads (bakers’ flour with and without wheat bran addition) to assess the performance of these prototypes. Prototypes showed a decreased quality compared to a baker’s flour control, however, a quality comparable to commercial wheat bran breads was found. This in combination with a lower release of reducing sugars during in vitro digestion underline the potential of fibre enriched breads as part of a healthier and more palateable low FODMAP diet. Furthermore, this study highlights the importance of the type (viscous and insoluble) and the concentration of fibres used. Application of psyllium in a concentration of 3 g/100 g showed the most beneficial impact on both physical (specific volume, hardness after 0 h and 24 h) and nutritional aspects of bread.
Prevalence of pathological FFRCT values without coronary artery stenosis in an asymptomatic marathon runner cohort
Authors: Gassenmaier Sebastian , Tsiflikas Ilias , Greulich Simon , Kuebler Jens , Hagen Florian , Nikolaou Konstantin , Niess Andreas M. , Burgstahler Christof , Krumm Patrick 
Published: May 2021

Abstract
Objectives
To evaluate computed tomography fractional flow reserve (FFRCT) values in distal parts of the coronaries in an asymptomatic cohort of marathon runners without any coronary stenosis for potentially false-positive values.

Methods
Ninety-eight asymptomatic male marathon runners (age 53 ± 7 years) were enrolled in a prospective monocentric study and underwent coronary computed tomography angiography (CCTA). CCTA data were analyzed for visual coronary artery stenosis. FFRCT was evaluated in 59 participants without coronary artery stenosis in proximal, mid, and distal coronary sections using an on-site software prototype.

Results
In participants without coronary artery stenosis, abnormal FFRCT values ≤ 0.8 in distal segments were found in 22 participants (37%); in 19 participants in the LAD; in 5 participants in the LCX; and in 4 participants in the RCA. Vessel diameters in participants with FFRCT values > 0.80 compared to ≤ 0.80 were 1.6 ± 0.3 mm versus 1.5 ± 0.3 mm for distal LAD (p = 0.025), 1.8 ± 0.3 mm versus 1.6 ± 0.5 mm for distal LCX (p = 0.183), and 2.0 ± 0.4 mm versus 1.5 ± 0.2 mm for distal RCA (p < 0.001).

Conclusions
Abnormal FFRCT values of ≤ 0.8 frequently occurred in distal coronary segments in subjects without any anatomical coronary artery stenosis. This effect is only to some degree explainable by small distal vessel diameters. Therefore, the validity of hemodynamic relevance evaluation using FFRCT in distal coronary artery segment stenosis is reduced.

Key Points
• Abnormal FFRCT values (≤ 0.8) occurred in over a third of the subjects in the distal LAD despite the absence of coronary artery stenosis..
• Therefore, the validity of hemodynamic relevance evaluation in distal coronary artery segment stenosis is reduced.
• Decision-making based on abnormal FFRCT values in distal vessel sections should be performed with caution and only in combination with visual assessment of the grade of stenosis..
Sex-specific differences and long-term outcome of patients with coronary artery disease and chronic kidney disease: the Coronary Artery Disease and Renal Failure (CAD-REF) Registry
Authors: Engelbertz Christiane , Pinnschmidt Hans O. , Freisinger Eva , Reinecke Holger , Schmitz Boris , Fobker Manfred , Schmieder Roland E. , Wegscheider Karl , Breithardt Günter , Pavenstädt Hermann , Brand Eva 
Published: May 2021

Abstract
Background
Cardiovascular morbidity and mortality are closely linked to chronic kidney disease (CKD). Sex-specific long-term outcome data of patients with coronary artery disease (CAD) and CKD are scarce.

Methods
In the prospective observational multicenter Coronary Artery Disease and REnal F﻿ailure (CAD-REF) Registry, 773 (23.1%) women and 2,579 (76.9%) men with angiographically documented CAD and different stages of CKD were consecutively enrolled and followed for up to 8 years. Long-term outcome was evaluated using survival analysis and multivariable Cox-regression models.

Results
At enrollment, women were significantly older than men, and suffered from more comorbidities like CKD, hypertension, diabetes mellitus, and multivessel coronary disease. Regarding long-term mortality, no sex-specific differences were observed (Kaplan–Meier survival estimates: 69% in women vs. 69% in men, plog-rank = 0.7). Survival rates decreased from 89% for patients without CKD at enrollment to 72% for patients with CKD stages 1–2 at enrollment and 49% for patients with CKD stages 3–5 at enrollment (plog-rank < 0.001). Cox-regression analysis revealed that sex or multivessel coronary disease were no independent predictors of long-term mortality, while age, CKD stages 3–5, albumin/creatinine ratio, diabetes, valvular heart disease, peripheral artery disease, and left-ventricular ejection fraction were predictors of long-term mortality.

Conclusions
Sex differences in CAD patients mainly exist in the cardiovascular risk profile and the extent of CAD. Long-term mortality was not depended on sex or multivessel disease. More attention should be given to treatment of comorbidities such as CKD and peripheral artery disease being independent predictors of death.
Clinical Trail Registration ClinicalTrials.gov Identifier: NCT00679419

Graphic abstract
Mutations in MT-ATP6 are a frequent cause of adult-onset spinocerebellar ataxia
Authors: Nolte Dagmar , Kang Jun-Suk , Hofmann Amrei , Schwaab Eva , Krämer Heidrun H. , Müller Ulrich 
Published: May 2021

AbstractAdult-onset ataxias are a genetically and clinically heterogeneous group of movement disorders. In addition to nuclear gene mutations, sequence changes have also been described in the mitochondrial genome. Here, we present findings of mutation analysis of the mitochondrial gene MT-ATP6. We analyzed 94 patients with adult-onset spinocerebellar ataxia (SCA), including 34 sporadic cases. In all patients, common sequence changes found in SCAs such as repeat expansions and point mutations had been excluded previously. We found pathogenic MT-ATP variants in five of these patients (5.32%), two of whom were sporadic. Four of the five mutations have not previously been described in ataxias. All but one of these mutations affect transmembrane helices of subunit-α of ATP synthase. Two mutations (p.G16S, and p.P18S) disrupt transmembrane helix 1 (TMH1), one mutation (p.G167D) affects TMH5, and another one (p.L217P) TMH6. The fifth mutation (p.T96A) describes an amino acid change in close proximity to transmembrane helix 3 (TMH3). The level of heteroplasmy was either complete or very high ranging from 87 to 99%. The high prevalence of pathogenic MT-ATP6 variants suggests that analysis of this gene should be included in the routine workup of both hereditary and sporadic ataxias.
Numerical effectiveness investigation of the automatic ball balancer with a deep chamber
Authors: Pakuła Sebastian 
Published: May 2021

AbstractThe article describes the simulation results of an unbalanced rotary machine with an automatic ball balancer with a deep chamber (ABB-DC) based on a mathematical model of such a system. The ABB chamber has a cylindrical shape and is filled with balls that can move freely in general motion. The model takes into account mutual collisions between the balls, as well as between the balls and the chamber. The model also includes friction forces and rolling resistance. The comparison of simulation results performed with two different construction types of the chamber, classic single-layer drum (ABB-SC) and ABB-DC, confirmed the better efficiency of the ABB-DC in the optimal range of the number of balls. The machine body movement was limited to planar motion. The correctness of such a limitation has been verified by analyzing waveforms of reaction forces of constraints and their moments. Waveforms were divided into transient and steady states. The results of the analysis indicate the additional constraints do not significantly affect machine body movements. However, this might affect the ball arranging process in the ABB chamber. The paper also presents details of performing numerical simulations based on the developed mathematical model and numerical tests to determine the optimal integration time-step.
Comparative analysis of the fragility curves for Italian residential masonry and RC buildings
Authors: da Porto Francesca , Donà Marco , Rosti Annalisa , Rota Maria , Lagomarsino Sergio , Cattari Serena , Borzi Barbara , Onida Mauro , De Gregorio Daniela , Perelli Francesca Linda , Del Gaudio Carlo , Ricci Paolo , Speranza Elena 
Published: May 2021

AbstractThe Department of Civil Protection (DPC), in compliance with the EU decision 1313/2013 and at the request of the Sendai Framework for Disaster Risk Reduction 2015–2030 to update the disaster risk assessments by various countries, released the latest National Risk Assessment for Italy at the end of 2018. Specifically, as regards the seismic risk assessment, six research units belonging to two centres of competence of the DPC collaborated under its guidance to update the risk maps of the Italian residential heritage. This extensive collaboration complied with the recent Italian code for Civil Protection, which requires a broad scientific consensus for risk assessment. During this research activity, six fragility models were developed, according to some common criteria (four for masonry buildings and two for RC buildings). These models were then implemented by the DPC for the definition of the national seismic risk. Within this context, the aim of this paper is to evaluate the risk results provided by these models, compare their features, and assess and validate their prediction capabilities. In particular, this paper shows the comparison of predicted and observed damage scenarios and consequences on building stock and the population of two seismic events, i.e. L’Aquila 2009 and Amatrice 2016. Furthermore, the paper provides some interesting damage and risk predictions at a national level. Overall, the forecasts and comparisons made in this study demonstrate the validity of the approach adopted by the DPC for the assessment of national seismic risk.
Assessment of water contamination by potentially toxic elements in mangrove lagoons of the Red Sea, Saudi Arabia
Authors: Alamri Dhafer Ali , Al-Solaimani Samir G. , Abohassan Refaat A. , Rinklebe Jörg , Shaheen Sabry M. 
Published: May 2021

AbstractMangrove (Avicennia marina) forests in the Red Sea cost have great concern from environmental, biological, economic, and social points of view. Therefore, assessing water contamination in this ecosystem is worth to be investigated. Consequently, here we aimed to examine the levels of salinity, acidity, and the total content of Fe, Mn, Cu, Zn, Cd, Cr, Ni, and Pb in water samples collected from the upper, middle, and lower part of three mangrove lagoons (i.e., Al-Shuaiba, Yanbu, and Jeddah), Red Sea, Saudi Arabia. The total metal content (µg L−1) in water samples differed significantly among the studied areas and ranged from 286.2 to 4815.0 for Fe, 86.4–483.0 for Mn, 22.9–468.8 for Cu, 199.2–366.6 for Zn, 44.1–99.8 for Cd, 25.6–80.3 for Cr, 11.6–41.5 for Ni, and from 17.7 to 102.0 for Pb. The mean values of Cu, Zn, Cd, and Pb were higher than the WHO water quality standards for fisheries. Water samples in Yanbu were more contaminated and contained higher concentrations of all metals than Jeddah and Al-Shuaiba, due to the petrochemical industries in this industrial area. Our findings suggest that the high metal content in the water of these mangrove sites, particularly in Yanbu, should be considered due to the high potential environmental and human health risks in these ecosystems. These results may help for demonstrating effective approaches for the management of these lagoons. More studies will be carried out on the sediment and mangrove plants in this ecosystem.
The far-infrared spectroscopic surveyor (FIRSS)
Authors: Rigopoulou D. , Pearson C. , Ellison B. , Wiedner M. , Okada V. Ossenkopf , Tan B. K. , Garcia-Bernete I. , Gerin M. , Yassin G. , Caux E. , Molinari S. , Goicoechea J. R. , Savini G. , Hunt L. K. , Lis D. C. , Goldsmith P. F. , Aalto S. , Magdis G. , Kramer C. 
Published: May 2021

AbstractWe are standing at the crossroads of powerful new facilities emerging in the next decade on the ground and in space like ELT, SKA, JWST, and Athena. Turning the narrative of the star formation potential of galaxies into a quantitative theory will provide answers to many outstanding questions in astrophysics, from the formation of planets to the evolution of galaxies and the origin of heavy elements. To achieve this goal, there is an urgent need for a dedicated space-borne, far-infrared spectroscopic facility capable of delivering, for the first time, large scale, high spectral resolution (velocity resolved) multiwavelength studies of the chemistry and dynamics of the ISM of our own Milky Way and nearby galaxies. The Far Infrared Spectroscopic Surveyor (FIRSS) fulfills these requirements and by exploiting the legacy of recent photometric surveys it seizes the opportunity to shed light on the fundamental building processes of our Universe.
Exoplanet mass estimation for a sample of targets for the Ariel mission
Authors: Barnes J. R. , Haswell C. A. 
Published: May 2021

AbstractAriel’s ambitious goal to survey a quarter of known exoplanets will transform our knowledge of planetary atmospheres. Masses measured directly with the radial velocity technique are essential for well determined planetary bulk properties. Radial velocity masses will provide important checks of masses derived from atmospheric fits or alternatively can be treated as a fixed input parameter to reduce possible degeneracies in atmospheric retrievals. We quantify the impact of stellar activity on planet mass recovery for the Ariel mission sample using Sun-like spot models scaled for active stars combined with other noise sources. Planets with necessarily well-determined ephemerides will be selected for characterisation with Ariel. With this prior requirement, we simulate the derived planet mass precision as a function of the number of observations for a prospective sample of Ariel targets. We find that quadrature sampling can significantly reduce the time commitment required for follow-up RVs, and is most effective when the planetary RV signature is larger than the RV noise. For a typical radial velocity instrument operating on a 4 m class telescope and achieving 1 m s−1 precision, between ~17% and ~ 37% of the time commitment is spent on the 7% of planets with mass Mp < 10 M⊕. In many low activity cases, the time required is limited by asteroseismic and photon noise. For low mass or faint systems, we can recover masses with the same precision up to ~3 times more quickly with an instrumental precision of ~10 cm s−1.