bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Wrapper Model for Multiobjective Forest Monitoring Systems
Authors: Roesch Francis A , Schroeder Todd A 
Published: April 2021

Abstract
Large multiobjective forest monitoring efforts such as the USDA’s Forest Inventory and Analysis Program and other National Forest Inventory (NFI) systems are usually described to the public in terms of the relationship of their sample designs to the land base of interest. Sometimes the third dimension of time is included in the description of the sample design. Additionally, there is a tendency to favor descriptions that arguably support design-based views of the used estimation systems. The accompanying justification usually relies on an assumption that design-based estimators are “objective,” whereas model-based estimators are “subjective.” This article posits that this argument misses the mark because design-based estimation begins with the assumption that a probability sample exists and that the sample observations have been obtained without error. In most large sampling efforts, it is known that violations of the sample design not only might, but will, occur. Additionally, some objectives in a multiobjective inventory require estimation of attributes of tangentially related populations. Here we unify estimation methods into an overall theoretical framework, or “wrapper” model, that allows for the recognition, acknowledgement, and accounting for nonsampling errors and imperfect sample frames into estimation systems capable of combining all observations available to analysts of these large inventory systems.
forked proteins are components of fiber bundles present in developing bristles of Drosophila melanogaster.
Authors: Petersen N S , Lankenau D H , Mitchell H K , Young P , Corces V G 
Published: April 2021

Abstract
The forked (f) gene of Drosophila melanogaster encodes six different transcripts 6.4, 5.6, 5.4, 2.5, 1.9, and 1.1 kb long. These transcripts arise by the use of alternative promoters. A polyclonal antibody raised against a domain common to all of the forked-encoded products has been used to identify forked proteins on two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis gels and in Drosophila pupal tissues. The antibody stains fiber bundles present in bristle cells for about 15 hr during normal pupal development. Electron microscopy shows that these fibers are present from 40 to 53 hr in bristles of wild-type flies but are absent in the null f36a mutant. The forked protein(s) thus appear to be an essential part of the bristle fibers. The phenotype of the f36a mutation can be rescued by a 13-kb fragment of the forked locus containing the coding regions for the 2.5, 1.9, and 1.1-kb transcripts, suggesting that the proteins encoded by the three large forked RNAs are dispensable during bristle development. Increasing the copy number of a P[w+,f+] construct containing the 13-kb fragment induces a hypermorphic bristle phenotype whose severity correlates with the number of copies of P[w+,f+] present. These results indicate that alterations in the ratios among the forked proteins, or between forked products and other components of the fiber, result in abnormal assembly of the fibrillar cytoplasmic structures necessary for bristle morphogenesis.
Pornography and Sexual Dissatisfaction: The Role of Pornographic Arousal, Upward Pornographic Comparisons, and Preference for Pornographic Masturbation
Authors: Wright Paul J , Paul Bryant , Herbenick Debby , Tokunaga Robert S 
Published: April 2021

Abstract
Research finding that pornography use is associated with lower sexual satisfaction is common; evaluation of the mechanisms hypothesized as underlying the association is not. Informed by multiple theoretical perspectives, the present study tested a conceptual model positing that (a) regularly consuming pornography conditions the user’s arousal template to be particularly responsive to pornographic depictions, (b) this amplified arousal to pornography increases both (c) upward comparisons between one’s own sex life and sex as it is represented in pornography and (d) a preference for masturbation to pornography over partnered sex, which in turn (e) weaken perceptions of how satisfying it is to have sex with one’s partner, and ultimately (f) decreases perceptions of how satisfying one’s relationship is with one’s partner. Path-analytic results were supportive of the hypothesized linkages for both men and women. Discussion focuses on the implications of the present study’s findings for current debates in the literature and theoretical development.
Placental Decidual Arteriopathy and Vascular Endothelial Growth Factor A Expression Among Women With or Without Human Immunodeficiency Virus
Authors: Bebell Lisa M , Parks Kalynn , Le Mylinh H , Ngonzi Joseph , Adong Julian , Boatin Adeline A , Bassett Ingrid V , Siedner Mark J , Gernand Alison D , Roberts Drucilla J 
Published: April 2021

Abstract

Background
Women with human immunodeficiency virus (HIV) (WHIV) are at higher risk of adverse birth outcomes. Proposed mechanisms for the increased risk include placental arteriopathy (vasculopathy) and maternal vascular malperfusion (MVM) due to antiretroviral therapy and medical comorbid conditions. However, these features and their underlying pathophysiologic mechanisms have not been well characterized in WHIV.

Methods
We performed gross and histologic examination and immunohistochemistry staining for vascular endothelial growth factor A (VEGF-A), a key angiogenic factor, on placentas from women with ≥1 MVM risk factors including: weight below the fifth percentile, histologic infarct or distal villous hypoplasia, nevirapine-based antiretroviral therapy, hypertension, and preeclampsia/eclampsia during pregnancy. We compared pathologic characteristics by maternal HIV serostatus.

Results
Twenty-seven of 41 (placentas 66%) assessed for VEGF-A were from WHIV. Mean maternal age was 27 years. Among WHIV, median CD4 T-cell count was 440/µL, and the HIV viral load was undetectable in 74%. Of VEGF-A–stained placentas, both decidua and villous endothelium tissue layers were present in 36 (88%). VEGF-A was detected in 31 of 36 (86%) with decidua present, and 39 of 40 (98%) with villous endothelium present. There were no differences in VEGF-A presence in any tissue type by maternal HIV serostatus (P = .28 to &gt;.99). MVM was more common in placentas selected for VEGF-A staining (51 vs 8%; P &lt; .001).

Conclusions
VEGF-A immunostaining was highly prevalent, and staining patterns did not differ by maternal HIV serostatus among those with MVM risk factors, indicating that the role of VEGF-A in placental vasculopathy may not differ by maternal HIV serostatus.
Public Tolerance of Retributive Violence against Insurgencies
Authors: Mironova Vera , Whitt Sam 
Published: April 2021

AbstractWhat drives public support for retributive violence against insurgents, a desire for revenge or security? We consider the case of suspected Islamic State (ISIS) militants in Mosul Iraq. Using survey experiments, we inquire about public support for judicial as well as extrajudicial violence against insurgent combatants. We sample among ordinary civilians in Mosul who lived under ISIS rule as well as ISIS-affiliated families in displacement camps outside Mosul. We find that many Mosul civilians are highly tolerant of retributive violence against insurgents, but this tolerance is driven primarily by security concerns rather than revenge. In contrast, others, especially in displacement camps, oppose the punitive killing of insurgents because they regard such actions as counterproductive to long-term security goals. This tension speaks to potential security dilemmas surrounding retaliatory responses to insurgency. Instead, public security interests may be better served through nonviolent strategies, to include negotiations with insurgent forces and more restorative approaches to justice.
Evaluation of the Clinical Performance of 7 Serological Assays for SARS-CoV-2 for Use in Clinical Laboratories
Authors: Plaga Alexis , Wei Ruhan , Olson Elizabeth , Payto Drew , Harrington John , Nwe-Kissig Pyik That , Strizzi Michelle , Zilka Sarah , Ko Jennifer , Colón-Franco Jessica M 
Published: April 2021

Abstract

Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological assays have emerged as a response to the global pandemic, warranting studies evaluating their clinical performance. This study investigated 7 commercially available SARS-CoV-2 serological assays in samples from noninfected individuals and hospitalized patients.

Methods
SARS-CoV-2 qualitative serological assays by Abbott (IgG), Beckman (IgG), DiaSorin (IgG), EUROIMMUN (IgG and IgA), Roche and Bio-Rad (Total) were evaluated using specimens collected pre-December 2019 (n = 393), from nucleic acid amplification testing (NAAT) negative patients (n = 40), and from 53 patients with COVID-19 by NAAT collected 3–21 days post-onset of symptoms (POS) (N = 83). Negative agreement (NA), positive agreement (PA), and positive and negative predictive values (PPV and NPV) at prevalences of 5% and 10% were calculated.

Results
The overall %NA; 95% CI in the negative samples were: Roche 99.8%; 99.3–100.2, Beckman 99.8%; 98.7–100.0, Abbott and Bio-Rad 99.3%; 98.0–99.9, DiaSorin 98.4; 97.2–99.6, EUROIMMUN IgG 97.5%; 95.5–98.7, and EUROIMMUN IgA 79.7%; 75.9–83.5), accounting for positive/equivocal results as false positives. The %PA; 95% CI in samples collected 14+ days POS (n = 24) were: Bio-Rad 83.3%; 68.4–98.2, Abbott and Roche 79.2%; 62.9–95.4, EUROIMMUN IgA 70.8%; 52.6–89.0, Beckman 58.3%; 38.6–78.1, DiaSorin 54.2; 34.2–74.1, and EUROIMMUN IgG 50.0%; 30.0–70.0, accounting for negative/equivocal results as false negatives. NPVs ranged from 97.4%–98.9% and 94.7%–97.7% for prevalences 5% and 10%, respectively. PPVs ranged from 15.5%–94.8% and 27.9%–97.4% for prevalences 5% and 10%, respectively.

Conclusion
The Roche and Beckman assays resulted in fewer false positives, followed by the Bio-Rad and Abbott assays. While the Bio-Rad assay demonstrated higher antibody detection in COVID-19-positive patients, PA claims cannot be established with a high level of confidence in our sample population.
Effects of vaccination against brucellosis and clostridia on the intake, performance, feeding behavior, blood parameters, and immune responses of dairy heifers calves
Authors: Diniz Neto Hilton C , Lombardi Mayara C , Campos Mariana M , Lage Andrey P , Silva Rodrigo O S , Dorneles Elaine Maria Seles , Lage Camila Flávia A , Carvalho Wanessa A , Machado Fernanda S , Pereira Luiz Gustavo R , Tomich Thierry R , Ramos Carolina P , Assis Ronnie A , Lobato Francisco Carlos F , Santana Jordana A , Santos Ethiene Luiza S , Andrade Rafaella S , Coelho Sandra G 
Published: April 2021

AbstractThe aim of this study was to identify possible effects of different vaccination strategies (concomitantly or not) against brucellosis and clostridia on intake, performance, feeding behavior, blood parameters, and immune responses of dairy heifers calves. Fifty heifers calves were enrolled [38 Gyr (Zebu, Bos taurus indicus) and 12 5/8 Holstein × Gyr]. At 120 d of age, animals were randomly distributed among 3 groups: B (n = 18), vaccinated against brucellosis; C (n = 14), vaccinated against clostridia and CB (n = 18), vaccinated concomitantly for both. Rectal and thermographic temperatures were evaluated on days −1, 0, 1, 2, 3, 5, 7,10, 14, and 28 relatives to the vaccination day. Feed and water intake, body weight (BW), and feeding behavior were monitored daily by an electronic feeding system. Blood was sampled on days 0, 3, 7, 14, and 28, relative to the vaccination day for determination of glucose and β -hydroxybutyrate (BHBA) concentrations. Blood sampled on day 0 (prevaccination) and on days 28 and 42 were used to evaluate the immune response against Brucella abortus and clostridia. There was an increase in rectal temperature between the first and the third day postvaccination in the 3 groups. The thermography revealed an increase of local temperature for 7 d on groups B and CB. Group C had increased local temperature for a longer period, lasting for up to 14 d. Dry mater intake was reduced for groups B and CB, but no alteration was observed for group C. No alterations regarding initial BW, final BW, average daily weight gain, and feed efficiency were observed. No differences were observed for the 3 vaccination groups for blood parameters throughout the evaluation period. The concomitant vaccination against brucellosis and clostridia led to lower neutralizing antibody titers against epsilon toxin of Clostridium perfringens and botulinum toxin type C of C. botulinum (C &gt; CB &gt; B). When cellular proliferation assay and serological tests to B. abortus were evaluated, no differences were observed between groups B and CB. The present results indicate that the concomitant vaccination against brucellosis and clostridia has no relevant impact on the intake, performance, and feeding behavior of dairy calves. However, the concomitant vaccination of vaccines against these 2 pathogens impacts animal immunity against clostridial infections.
Screening Breast MRI Primer: Indications, Current Protocols, and Emerging Techniques
Authors: Samreen Naziya , Mercado Cecilia , Heacock Laura , Chacko Celin , Partridge Savannah C , Chhor Chloe 
Published: April 2021

AbstractBreast dynamic contrast-enhanced MRI (DCE-MRI) is the most sensitive imaging modality for the detection of breast cancer. Screening MRI is currently performed predominantly in patients at high risk for breast cancer, but it could be of benefit in patients at intermediate risk for breast cancer and patients with dense breasts. Decreasing scan time and image interpretation time could increase cost-effectiveness, making screening MRI accessible to a larger group of patients. Abbreviated breast MRI (Ab-MRI) reduces scan time by decreasing the number of sequences obtained, but as multiple delayed contrast enhanced sequences are not obtained, no kinetic information is available. Ultrafast techniques rapidly acquire multiple sequences during the first minute of gadolinium contrast injection and provide information about both lesion morphology and vascular kinetics. Diffusion-weighted imaging is a noncontrast MRI technique with the potential to detect mammographically occult cancers. This review article aims to discuss the current indications of breast MRI as a screening tool, examine the standard breast DCE-MRI technique, and explore alternate screening MRI protocols, including Ab-MRI, ultrafast MRI, and noncontrast diffusion-weighted MRI, which can decrease scan time and interpretation time.
Illustrated Morphological Keys for Fleas (Siphonaptera) in Madagascar
Authors: Harimalala Mireille , Ramihangihajason Tojo R , Rakotobe Harimanana Ravo , Girod Romain , Duchemin Jean-Bernard 
Published: April 2021

AbstractMadagascar has an important diversity of fleas (Siphonaptera), which almost species do not exist elsewhere. Scientists have provided huge efforts to improve knowledge on Malagasy fleas since the middle of 1900s particularly by investigating topics such as taxonomy, systematics, biogeography, and flea vector role. Since then, new species discovery has increased and currently, 48 species are recorded which the majority is endemic. Therefore, it becomes necessary to have updated keys to identify species membership. This paper presents morphological-based keys to identify at genus and species levels adult fleas reported as occurring in Madagascar. Illustrations are proposed to make easier the observation of morphological criteria, which may be tricky for sibling species.
Biosurveillance and Research Needs Involving Area-Wide Systematic Active Sampling to Enhance Integrated Cattle Fever Tick (Ixodida: Ixodidae) Eradication
Authors: Showler Allan T , Pérez de León Adalberto , Saelao Perot 
Published: April 2021

Abstract
The one-host cattle fever tick, Rhipicephalus (Boophilus) annulatus (Say), and southern cattle fever tick, Rhipicephalus (Boophilus) microplus (Canestrini), are important ectoparasitic pests of cattle, Bos taurus L., mostly for transmitting the causal agents of bovine babesiosis. Bovine babesiosis inflicted substantial cattle production losses in the United States before the vectors were eliminated by 1943, with the exception of a Permanent Quarantine Zone in South Texas, a buffer along the Mexico border where the invasive ixodids remain. As suitable hosts, infested white-tailed deer and nilgai antelope populations disperse R. annulatus and R. microplus, which increases the risk for emergence of bovine babesiosis in the United States. A R. microplus incursion first detected in 2016 on the South Texas coastal plain wildlife corridor involved infestations on cattle, nilgai antelope, white-tailed deer, and vegetation. Efforts at passive sampling of Rhipicephalus (Boophilus) spp. on hosts are concentrated in the Permanent Quarantine Zone. Hence, a knowledge gap exists on the full extent of the recent incursions. Area-wide, systematic, active sampling and supportive research, involving the Permanent Quarantine Zone, Temporary Quarantine Zone, most of the coastal plain, and other parts of Texas outside of the quarantine zones, are needed to bridge the knowledge gap. Herein, we provide research perspectives and rationale to develop and implement systematic active sampling that will provide an increasingly accurate assessment of Rhipicephalus (Boophilus) spp. distribution in Texas. We suggest that this is essential to advance integrated vector-borne animal disease eradication approaches for keeping cattle free of bovine babesiosis.
How Not to Defend the Unborn
Authors: Hershenov David , Reed Philip A 
Published: April 2021

Abstract
It is sometimes proposed that killing or harming abortion providers is the only logically consistent position available to opponents of abortion. Since lethal violence against morally responsible attackers is normally viewed as justified in order to defend innocent parties, pro-lifers should also think so in the case of the abortion doctor and so they should act to defend the unborn. In our paper, we defend the mainstream pro-life view against killing abortion doctors. We argue that the pro-life view can, in various ways, reject the assumption that defensive violence to save innocent individuals is always permissible. Now even if that assumption is accepted, we contend that defensive violence against abortion doctors still is not justified. Drawing on Frances Kamm’s work, we contend that there are structural similarities between abortion and letting someone die who needs your help to stay alive; and we argue that it is impermissible to kill those who kill in order to avoid giving life-saving aid.
The Impact of Intensifying Prostate Cancer Screening in Black Men: A Model-Based Analysis
Authors: Nyame Yaw A , Gulati Roman , Heijnsdijk Eveline A M , Tsodikov Alex , Mariotto Angela B , Gore John L , Etzioni Ruth 
Published: April 2021

Abstract

Background
Black men in the United States have markedly higher rates of prostate cancer than the general population. National guidelines for prostate-specific antigen (PSA) screening do not provide clear guidance for this high-risk population. The purpose of this study is to estimate the benefit and harm of intensified PSA screening in Black men.

Methods
Two microsimulation models of prostate cancer calibrated to incidence from the Surveillance, Epidemiology, and End Results program among Black men project the impact of different screening strategies (varying screening intervals, starting and stopping ages, and biopsy utilization following an abnormal PSA) on disease-specific mortality and overdiagnosis. Each strategy induces a mean lead time (MLT) for detected cases. A longer MLT reduces mortality according to estimates combining the US and European prostate cancer screening trials but increases overdiagnosis.

Results
Under historical population screening, Black men had similar MLT to men of all races and similar mortality reduction (range between models = 21%-24% vs 20%-24%) but a higher frequency of overdiagnosis (75-86 vs 58-60 per 1000 men). Screening Black men aged 40-84 years annually would increase both mortality reduction (29%-31%) and overdiagnosis (112-129 per 1000). Restricting screening to ages 45-69 years would still achieve substantial mortality reduction (26%-29%) with lower overdiagnosis (51-61 per 1000). Increasing biopsy utilization to 100% of abnormal tests would further reduce mortality but substantially increase overdiagnosis.

Conclusions
Annual screening in Black men is expected to reduce mortality more than that estimated under historical screening. Limiting screening to men younger than 70 years is expected to help reduce overdiagnosis.
Internal carotid artery false aneurysm as a fatal complication of transsphenoidal surgery
Authors: Sumislawski Piotr , Ludwig Carolin , Rotermund Roman , Grzyska Ulrich , Flitsch Jörg 
Published: April 2021

Abstract
False aneurysm of internal carotid artery (ICA) is a rare but serious vascular complication observed after transsphenoidal pituitary surgery. Here, we present a 41-year-old woman with a pseudoaneurysm in the ophthalmic1 segment of the left ICA after exoscopic transsphenoidal pituitary surgery. The initially uneventful procedure was complicated by a subarachnoidal hemorrhage 10 days after the surgery, which was confirmed by cranial computed tomography scan. The emergency angiography revealed a pseudoaneurysm of the ophthalmic1 part of the left ICA. Despite repeated endovascular treatments with a flow diverter and coiling, the patient experienced a re-bleeding with consecutive vasospasms, occlusion hydrocephalus and finally bifrontal intracerebral hemorrhage with fatal outcome. As a conclusion in irregular post-operative courses with for example headache, a post-operative magnetic resonance imaging with vessel presentation using TOF sequence and contrast-enhanced MRA might be recommended in order to detect a possible pseudoaneurysm in an early stage.
Jean Toomer afterCane
Authors: Licato Amanda Mehsima 
Published: April 2021

AbstractI reassess Jean Toomer’s poetics after the publication of his first novel Cane (1923). Cane’s critical reception has impacted and limited our understanding of his poetry, and of his racial identification, from the late 1920s to 1940s, when Toomer sought inspiration from the Eastern mystic, George Ivanovich Gurdjieff, and later from the Religious Society of Friends, or Quakers. Challenging the neat binary of Toomer’s lyrical and didactic strains in his later work, and spotlighting the complexity of his racial posturing, I argue that the central elements of Toomer’s poetics remained constant, particularly his attention to moral and spiritual enlightenment in order to address the pressing psychosocial and racial issues of his time.