bluuebunny/crossref_metadata_2025_split huggingface dataset:
Axonal damage determines clinical disability in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): A prospective cohort study of different CIDP subtypes and disease stages
Authors: Grüter Thomas , Motte Jeremias , Bulut Yesim , Kordes Anna , Athanasopoulos Diamantis , Fels Miriam , Schneider‐Gold Christiane , Gold Ralf , Fisse Anna Lena , Pitarokoili Kalliopi 
Published: October 2021

AbstractBackground and purposeMonitoring of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is challenging in daily medical practice because the interrelationship between clinical disability, CIDP subtype, and neuronal degeneration is still elusive. The aim of this prospective cohort study was to investigate the role of different electrophysiological variables in CIDP monitoring.MethodsComprehensive bilateral nerve conduction studies (NCS) and structured clinical examinations were performed in 95 patients with typical CIDP and CIDP variants (age at inclusion 58.6 ± 11.6 years; median [range] inflammatory neuropathy cause and treatment overall disability score (INCAT‐ODSS) 3 [0–9]), at time of first diagnosis in 25 of these patients (based on data from the prospective Immune‐mediated Neuropathies Biobank registry). After 12 months, 33 patients underwent follow‐up examination. Typical CIDP patients and patients with CIDP variants were characterized electrophysiologically and each individual NCS variable and the overall sum score for axonal damage and demyelination were then correlated to clinical disability scores (INCAT‐ODSS, modified Medical Research Council (MRS) sum score, and INCAT sensory score).ResultsAs opposed to demyelination markers, the NCS axonal damage variable correlated strongly with disability at both first diagnosis and advanced disease stages in cross‐sectional and longitudinal analyses. Distal compound muscle action potential amplitudes of the upper limbs were found to have the strongest correlation with overall clinical function. Typical and atypical CIDP variants had distinct electrophysiological characteristics but, in typical CIDP, axonal degeneration markers were more strongly associated with clinical disability.ConclusionsTotal disability is largely determined by the degree of axonal damage, especially in typical CIDP. Although most patients have symptoms predominantly in the legs, NCS of the upper limbs are essential for the monitoring of patients with CIDP and CIDP variants.
Effects of a supervised therapeutic exercise program on musculoskeletal health and gait in patients with haemophilia: A pilot study
Authors: Deniz Volkan , Guzel Nevin Atalay , Lobet Sébastien , Antmen Ali Bülent , Sasmaz Hatice Ilgen , Kilci Abdullah , Boyraz Omer Cumhur , Gunaştı Ozgür , Kurdak Sanli Sadi 
Published: October 2021

AbstractIntroductionEpisodes of bleeding in patients with haemophilia (PwH) are associated with haemophilic arthropathy, limitations in physical performance, reduced quality of life (QoL), and gait disorders.AimThis non‐randomized, controlled, interventional, prospective, single‐centre pilot study aimed to assess the effects of an 8‐week supervised therapeutic exercise program on musculoskeletal health, gait kinematic parameters (GKP), functional capacity, and QoL in adult PwH.MethodsNineteen PwH were allocated to an exercise group (n = 10) or a control group (n = 9). The patients in the exercise group followed an 8‐week supervised therapeutic exercise program. The Haemophilia Joint Health Score (HJHS), a two‐dimensional video‐based gait kinematic analysis (2D‐GKA), the 6‐min walking test (6MWT), and the Haemophilia Quality of Life Questionnaire for Adults (Haem‐A‐Qol) were used as the outcome measures at baseline, after the exercise program (at the 8th week), and at the 6th‐month follow‐up.ResultsA significant improvement was observed in the exercise group in the HJHS‐Total and Haem‐A‐Qol Total scores and the 6MWT value after the exercise program. Moreover, the 2D‐GKA revealed improvement in most of the GKP (knee extension during the midstance and late swing phases, ankle dorsiflexion during the midstance phase, and ankle plantar flexion during the preswing phase). However, the gain obtained by the exercise program was not maintained at the 6th‐month follow‐up for the HJHS‐Total and Hem‐A‐QoL‐Total scores and GKP.ConclusionThe 8‐week supervised therapeutic exercise program was successful in achieving improvement in joint health, GKP, functional capacity, and QoL in PwH.
Renal safety and biochemical changes for 2 years after switching to tenofovir alafenamide from long‐term other nucleotide analog treatment in patients with chronic hepatitis B
Authors: Hosaka Tetsuya , Suzuki Fumitaka , Kobayashi Masahiro , Fujiyama Shunichirou , Kawamura Yusuke , Sezaki Hitomi , Akuta Norio , Suzuki Yoshiyuki , Saitoh Satoshi , Arase Yasuji , Ikeda Kenji , Kobayashi Mariko , Kumada Hiromitsu 
Published: October 2021

AbstractBackgroundLong‐term use of nucleotide analogs such as adefovir (ADV) or tenofovir disoproxil fumarate (TDF) may cause renal impairment. Tenofovir alafenamide (TAF) has less systemic exposure than TDF did. The aims were to examine longitudinal changes in renal function and biochemical parameters for 2 years after switching from long‐term ADV and TDF to TAF, and to explore factors associated with improved renal function after TAF in patients with chronic hepatitis B.MethodsThe prospective observational cohort study included 306 patients with chronic hepatitis B who underwent switching from long‐term TDF or ADV to TAF. The primary outcome was the changes in estimated glomerular filtration rate (eGFR) after TAF.ResultsAmong 306 patients, 190 (65.3%) and 106 (34.7%) had chronic kidney disease (CKD) stages 1–2 and 3a–4 at baseline. In patients with CKD stages 3a–4, the mean eGFR significantly increased until week 12 and plateaued from week 12 to year 2 (adjusted slope using linear mixed effect models: +9.01 ml/min/1.73 m2/year until week 12; p < 0.001). In contrast, the mean eGFR plateaued from baseline to year 2 in the CKD stages 1–2 subgroup. Multivariate logistic regression showed that baseline CKD stage ≥3a, steeper decline in eGFR 1 year before TAF, and shorter duration of any nucleotide analog use was significantly associated with ≥10% improvement in eGFR in year 1.ConclusionsSwitching from TDF or ADV to TAF resulted in favorable renal safety for 2 years. In CKD stage 3a–4 subgroup, eGFR after TAF was recovered in the first 12 weeks and subsequently stabilized.
Social engagement as a proto‐institution: Histories of institutional emergence in the Israeli higher education field
Authors: Sapir Adi 
Published: October 2021

AbstractThis paper aims to provide an historical perspective on the development of higher education's ‘third mission’ of social engagement. I explore how practices and structures of ‘social engagement’ emerged in the Israeli higher education field in the 1970s and early 1980s. Drawing on archival research in three universities' historical archives, and on the theoretical lens of neo‐institutional theory, I explore the origins and emergence of social engagement as a proto‐institution, that is, an institution in the making. My analysis suggests that the current dominant model of engagement in the Israeli field, based on one‐on‐one tutoring for scholarships, has come to marginalize other initiatives that were based on principles of social action. I show how the emergence of a new proto‐institution in an established field is shaped by processes of institutional work, through which actors create, maintain and disrupt institutions.
Value co‐creation and co‐destruction behaviour: Relationship with basic human values and personality traits
Authors: Ogunbodede Olabode , Papagiannidis Savvas , Alamanos Eleftherios 
Published: October 2021

AbstractService systems create value when actors exhibit behaviours expected to facilitate resource integration and could destroy value when actors do not exhibit the expected set of behaviours. This study seeks to determine which groups of values and individual traits facilitate consumer co‐creation and co‐destruction behaviours. A data set of 390 online survey responses from consumers in the United States was analysed using multiple regression. The analysis suggests that values which express self‐enhancement and openness‐to‐change are most likely to facilitate co‐destruction behaviour, while values which express self‐transcendence and conservation are most likely to facilitate co‐creation behaviour. With regards to traits, we find that neurotic traits are most likely to facilitate co‐destruction behaviour and least likely to facilitate co‐creation behaviours. Conscientious and agreeable traits are least likely to facilitate co‐destruction behaviours, while extraversion and openness traits are most likely to facilitate co‐creation behaviours. This study contributes to the literature by providing a better understanding of the consumer values and traits which facilitate co‐destruction and co‐creation behaviour. This study also shows that the basic human values circumplex structure can be divided to reflect co‐destruction and co‐creation values. The polar opposites of the big five personality traits can be classified based on their tendencies to co‐destroy or co‐create value.
High‐pressure processing at increased temperatures provides enhanced removal of indigenous microbial contamination in beet/carrot juice without damaging the bioactive components
Authors: Szwajgier Dominik , Baranowska‐Wójcik Ewa , Sosnowska Bożena , Kukula‐Koch Wirginia , Paduch Roman , Sokołowska Barbara , Waśko Adam , Solarska Ewa 
Published: October 2021

SummaryIn this study, an optimised high hydrostatic pressure process (600 MPa, 15 min, 55 and 65 °C) caused elimination of microbial levels in beetroot/carrot juice (80:20 v/v, pH 4.0) after 28 days of storage (4 °C) (psychrotrophic bacteria, yeast and mould counts below the limit of detection = 0 log cfu mL−1). Room temperature (20 °C) was insufficient for the complete elimination of psychrotrophic bacteria (0.9–2.0 log cfu mL−1 after 7–28 days of storage). No significant (P < 0.05) changes in the polyphenol content were observed (1.11 ± 0.13 in control vs. 1.13 ± 0.13 mg gallic acid mL−1 in samples treated at 65 °C). No significant (P < 0.05) changes in the antioxidant, antiradical activity and biological properties of the high‐pressure processing (HPP)‐treated juice were observed in the studies involving CCD 841 CoTr and HT29 cell lines. The HPLC‐MS analysis confirmed increase in isobetalain, decarboxybetalain and betalain content (by 100%, 14% and 10%) and loss of vulgaxanthin I (by 65%) after HPP at 65 °C. The innovative character of this paper stems from the comprehensive quality assessment (especially experiments involving cell lines) of high‐quality, safe beetroot–carrot juice that retains a major part of its bioactive compounds.
Stability of bioactive compounds in liposomes after pasteurisation and storage of functional chocolate milk
Authors: Marsanasco Marina , Alonso Silvia del V. 
Published: October 2021

SummaryIn the present study, liposomes with bioactive compounds (BC), vitamin E (VE) and vitamin C (VC), were characterised after pasteurisation and storage in chocolate milk. Liposomes were obtained using soy phosphatidylcholine (SPC), SPC with stearic acid (SA) or calcium stearate (CaS). Oxidative stability, size, shape and membrane packing were studied after pasteurisation and storage for 28 days at 4 °C. Oxidative stability was also studied after pasteurisation in extreme conditions: 6 months, 25 °C and light. The oxidative level determined in liposomes is much under the permitted limits, generating good quality food. SPC maintained stability in size, shape and membrane packing for 28 days at 4 °C. SPC:SA and SPC:CaS evidenced a decrease in liposomal aggregation and a higher membrane packing for 28 days at 4 °C, which favoured stability. These results were optimum because commercial functional milk must have a shelf life of 7 days at 4 °C. Pasteurised liposomes were incorporated in chocolate milk to study the sensory (after storage for 7 days at 4 °C) and microbiological stability. None of the liposomes contributed to the microbial load. SPC:SA presented high sensorial stability in the milk, being a potentially suitable medium to incorporate BC generating functional food.
Anti-inflammatory potential of Lactobacillus reuteri LM1071 via eicosanoid regulation in LPS-stimulated RAW264.7 cells
Authors: Jang A-yeong , Rod-in Weerawan , Monmai Chaiwat , Sohn Minn , Kim Tae-rahk , Jeon Min-Gyu , Park Woo Jung 
Published: October 2021

Abstract

Aims
To investigate anti-inflammatory effects of Lactobacillus reuteri LM1071 in lipopolysaccharides (LPS)-induced inflammation RAW264.7 cells.

Methods and Results
To evaluate anti-inflammatory activities of L. reuteri LM1071, LPS-stimulated RAW264.7 cells were used. Gene expression levels of eight immune-associated genes including IL-1β, IL-6 and TNF-α and protein production levels of COX-1 and COX-2 were analysed. Moreover, the production of eicosanoids as important biomarkers for anti-inflammation was determined.

Conclusions
The current study demonstrates that L. reuteri LM1071 has anti-inflammatory potential by inhibiting the production of inflammation mediators such as NO, eicosanoids such as PGE1 & PGE2, pro-inflammatory cytokines and COX proteins. It can also enhance the production of inflammatory associated genes such as IL-11, BMP4, LEFTY2 and EET metabolite.

Significance and Impact of the Study
Lactobacillus reuteri is one of the crucial bacteria for food fermentation. It can be found in the gastrointestinal system of human and animals. Several studies have shown that L. reuteri has valuable effects on host health. The current study firstly demonstrated that L. reuteri has a beneficial effect on the inflammation containing the variation of eicosanoids (PGE1 and PGE2) which are one of the most important biomarkers and moreover eicosanoid-associated genes as well as proteins (COX-2).
Characterizing the direct care health workforce in the United States, 2010–2019
Authors: Jumabhoy Sara , Jung Hye‐Young , Yu Jiani 
Published: October 2021

AbstractBackgroundTo describe the growth and characteristics of the direct care health workforce, encompassing home health aides, personal care aides, nursing assistants, and orderlies and psychiatric aides from 2010 to 2019 in the United States.MethodsUsing nationally representative data from the 2010 to 2019 American Community Survey, we described the growth in the direct care health workforce overall and by type of direct care health worker. In addition, we examined the distribution of direct care workers by geographic region of the country, age categories, citizenship, world area of birth, income, health insurance status, and other characteristics.ResultsFrom 2010 to 2019, the number of direct care health workers in the United States per 10,000 individuals decreased slightly from 135.81 in 2010 to 133.78 in 2019. Personal care aides made up 42.1% of the direct care health workforce in 2019, followed by nursing assistants (39.5%) and home health aides (16.3%). In 2019, the number of direct care health workers who were not U.S. citizens accounted for roughly 10% of all workers in each year. The relative percentage of direct care health workers that were not a citizen of the United States was highest among home health aides (16.3%). Among workers born outside of the United States, the majority were from Latin America, followed by Asia.ConclusionFrom 2010 to 2019, there was little growth in the direct care health workforce despite growing demand for direct care health workers. In the midst of the current and projected shortage of direct care health workers—particularly during the COVID‐19 pandemic, longer‐term solutions to improve retention of direct care health workers and increase the supply of direct care health workers may be needed.
Burnout in MFT trainees: Impact of demands and resources
Authors: Glebova Tatiana , Lal Arpita , Girard Alix , Van Ligten Jessica 
Published: October 2021

AbstractBurnout, defined as a state of physical, mental, and emotional exhaustion caused by involvement in emotionally demanding work, is an occupational risk of helping professions that has significant negative consequences. This study examined burnout among Couple/Marriage and Family Therapy (C/MFT) trainees and its association with various demands and resources at the individual and practice‐related levels as well as variables specific to their trainee status. Data came from an online study on 78 C/MFT trainees from 13 states enrolled in Couple and Family Therapy graduate programs nationwide. More than half of the participants reported various levels of burnout indicating that the issue of burnout merits the special attention of C/MFT educators and supervisors. All significant factors associated with burnout were related to the training context and included: supervision satisfaction, hours spent in a setting and caseload dissatisfaction. Findings and implications for supervision are discussed in the context of C/MFT training.
Updated review on prognostic factors in mycosis fungoides and new skin lymphoma trials
Authors: Farabi Banu , Seminario‐Vidal Lucia , Jamgochian Marielle , Akay Bengu Nisa , Atak Mehmet Fatih , Rao Babar K. , Karagaiah Priyanka , Grabbe Stephan , Goldust Mohamad 
Published: October 2021

AbstractBackgroundTen‐year survival rates in mycosis fungoides (MF) broadly varies, however, there is no standardized prognostic index available. This is presumably due to low prevalence, heterogeneity, and diagnostic challenges in MF. Recent studies have focused on identifying objective prognostic indices by using different parameters for survival determinants. The Cutaneous Lymphoma International Prognostic Index (CLIPI) and the Prospective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) represent prototypical studies that identify prognostic factors, seeking to improve management and outcomes in early‐stage MF. Detecting these factors and stratifying MF patients according to their disease progression risk may help to manage these patients more efficiently.AimsReview the current literature to determine the risk factors determining prognosis in MF.MethodologyA Comprehensive literature search was performed using electronic online databases "PubMed" and "Google Scholar" using key words ‘prognostic factor’, ‘prognostic indicator’, ‘mycosis fungoides’, ‘Sezary syndrome’, ‘Skin Lymphoma’, ‘Cutaneous Lymphoma’. Articles published in English language were considered for the review.ResultsThe strongest prognostic factor in MF patients is the stage of the disease. T stage and the presence of extracutaneous disease are the most important factors for survival. Other factors that are associated with worse prognosis are male gender, age >60, presence of plaques, folliculotropism, eosinophilia and lymph node stage above N1/Nx. Elevated LDH was associated with later tumor stages and large cell phenotype at diagnosis had a better prognosis. KIR3DL2 was associated with malignant transformation.ConclusionThe PROCLIPI study has assessed risk factors collected in MF patients from different countries and across different ethnicities following a rigorous clinicopathologic process. The findings presented here illustrated that disease prognosis in early stages depends on many contributing factors. Detection and stratification of such factors may allow a personalized approach to management of these patients.
Holding on and letting go: Views about filial piety among adult children living in New Zealand
Authors: Montayre Jed , Saravanakumar Padmapriya , Zhao Ivy , Holroyd Eleanor , Adams Jeffery , Neville Stephen 
Published: October 2021

AbstractAims and ObjectivesThe study aimed to explore the perspectives of adult children about late‐life living and care arrangements for their ageing immigrant parents living in New Zealand.BackgroundOlder immigrants’ well‐being is closely associated with filial relations and is often reliant on families as a main source of social, financial and emotional support. Research among migrant Asian adults has reported mixed findings regarding intergenerational perspectives of filial practices.DesignQualitative design using focused ethnographic lens.MethodsSemi‐structured individual interviews were undertaken with 45 adult children of older immigrants living in New Zealand to explore their views about filial piety. The CoREQ checklist was used in reporting methods and findings.ResultsTwo major themes were identified in this study of adult children's view of filial piety and late‐life care for their ageing parents. The first theme, ‘holding on—reconfiguring values’, referred to a process described by the participants as upholding the core values and cultural familial expectations, looking after their ageing parents, yet modifying the ways in which they provide care. The second major theme ‘letting go—reconfigured expectations’, described participants’ views of aged care for themselves, which meant they no longer held traditional values that needed to be enacted by their children.ConclusionsAdult children from immigrant families were positioned as intermediaries of these shifting values of their own and within younger generations. The adult children's shift of thinking and acceptance of reconfigured expression of filial duties impact care and living arrangements of older people from immigrant and culturally diverse backgrounds, which also influences health and well‐being in later life.Relevance to clinical practiceHealthcare professionals including nurses working in the ageing and aged care sector need to accommodate the changing generational perspectives about filial piety to cater to the unique late‐life care requirements and health needs of older people and their families.
Retinal defocus in myopes wearing dual‐focus zonal contact lenses
Authors: Singh Neeraj K , Meyer Dawn , Jaskulski Matt , Kollbaum Pete 
Published: October 2021

AbstractPurposeTo evaluate the refractive impact of dual‐focus (DF) myopia control contact lenses (CLs) on accommodating young myopic adults.MethodsPhase 1: accommodative accuracy was assessed in 40 myopic participants. Phase 2: a subset of four subjects who demonstrated accurate accommodation and six who chronically underaccommodated were fitted with single vision (SV, Proclear 1 day) and centre‐distance DF myopia control CLs (MiSight 1 day) with approximately +2.00 D of additional power in two surrounding annular zones. While binocularly viewing high contrast characters at 4.00, 1.00, 0.50, 0.33, 0.25 and 0.20 m, aberrometry data were captured across the central ±30° of the horizontal retina. Local refractive errors were pooled for each area of the pupil covered by the central distance or first annular defocus zone of the DF CLs.ResultsIn the “good” accommodator group fitted with SV CLs, accommodative lags were generally absent except at the closest viewing distance (mean errors: −0.09 ± 0.22 D, −0.12 ± 0.26 D, −0.05 ± 0.37 D and +0.38 ± 0.54 D for −2.00, −3.00, −4.00 and −5.00 D target vergences, respectively) but significantly larger in the “poor” accommodating participants (+0.81 ± 0.21 D, +0.97 ± 0.27 D, +1.18 ± 0.39 D, +1.47 ± 0.55 D). For most viewing distances, hyperopic defocus observed in the region of the pupil covered by the first annular zone was replaced with myopic defocus when fitted with the DF CLs. Myopic defocus created by the first annular region was present across the central 30° of the retina.ConclusionsSome young adult myopes chronically experience high levels of hyperopic defocus when viewing near targets, which was replaced by myopic defocus in the annular part of the pupil covered by the treatment zones when fitted with a centre‐distance myopia control DF CL.