bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Pelaksanaan Pijat Bayi Kepada Ibu Yang Memiliki Bayi di Desa Pondok Keumuning, Pondok Kelapa dan Pondok Nias
Authors: Fazdria Fazdria , Veri Nora , Mutiah Cut , Dewita Dewita 
Published: December 2021

ABSTRAK Di Indonesia, meskipun sejarah pemijatan berawal dari nenek moyang masa lampau, namun pijat bayi yang diperkenalkan bukanlah pijat tradisional yang dilakukan oleh dukun bayi atau dukun pijat yang pijatannya tidak aman. Pijat bayi yang dimasyarakatkan adalah pijat modern yang memadukan antara ilmiah (kesehatan), seni, dan kasih sayang. Pijat bayi akan membuat bayi tidur lebih lelap dan meningkatkan kosentrasi kesiagaan (alertness) atau kosentrasi. Hal ini disebabkan pijatan dapat mengubah gelombang otak. Pengubahan ini terjadi dengan cara menurunkan gelombang alpha dan peningkatan gelombang beta, serta tetha yang dapat dibuktikan dengan penggunaan EEG (electro enchephalogram). Tujuan kegiatan adalah meningkatkan pengetahuan dan keterampilan ibu dalam melakukan pijat bayi di Desa Pondok Kelapa, Pondok Nias dan Pondok Kemuning Kec. Langsa Baro Kota Langsa. Metode pengabdian yang digunakan dalam kegiatan ini adalah program pendidikan masyarakat melalui edukasi dan pelatihan pijat bayi pada ibu bayi dan balita. Hasil pengabdian kepada masyarakat yang telah dilakukan oleh Dosen Prodi D-III Kebidanan Langsa pada tanggal 30 September s/d 2 Oktober 2020 didapatkan hasil mayoritas peserta pengabdian kepada masyarakat memiliki pengetahuan yang baik tentang pijat bayi yaitu sebanyak 17 orang (56,7%) dan mayoritas terampil dalam melakukan pijat bayi yaitu sebanyak 22 orang (73,3%). Kata Kunci : Pengetahuan, Keterampilan, Pijat Bayi ABSTRACT In Indonesia, although the history of massage dates back to the ancestors of the past, the baby massage introduced is not a traditional massage performed by a baby shaman or a massage shaman whose massage is not safe. A popularized baby massage is a modern massage that blends scientific (health), art, and compassion. Baby massage will make the baby sleep better and increase alertness or concentration. This is because massage can alter brain waves. This conversion occurs by lowering alpha waves and increasing beta waves, as well as tetha which can be proven by the use of EEG (electroencephalogram). The purpose of the activity is to improve the knowledge and skills of mothers in performing baby massage in Pondok Kelapa Village, Pondok Nias, and Pondok Kemuning Kec. Langsa Baro Langsa City. The method of devotion used in this activity is a community education program through the education and training of baby massage in infants and toddler mothers. The results of community service that has been done by Lecturers of Prodi D-III Midwifery Langsa on September 30 to October 2, 2020, obtained the results of the majority of participants of community service have good knowledge about baby massage that is as many as 17 people (56.7%) and the majority are skilled in performing baby massage that is as many as 22 people (73.3%). Keywords: Knowledge, Skills, Baby Massage
Green engineering principles and application: bioremediation
Authors: Hadibarata Tony , Voijant Tangahu Bieby 
Published: December 2021

The adulteration of the environment by hazardous waste, such as heavy metals, nuclear wastes, hydrocarbons, pesticides and greenhouse gases is the major serious problem which need to be reduced. Common remediation technique such as physical, chemical and biological process are being applied. Chemical process can transform and change organic contaminant of interest which is not sufficient to clean the environment, while physical technique requires additional equipment. Thus, bioremediation exist as green approach to eliminate the hazardous waste in the environment. In this review, bioremediation is comprehensively presented. Remediation process types, challenges, limitations, mechanisms, and future suggestion has been elaborated to develop bioremediation technology for future prospect.
Method for diagnosing non-alcoholic liver steatosis
Authors: Bulatova I. A. , Miftakhova A. M. , Gulyaeva I. L. 
Published: December 2021

Purpose of the study.Development of a non-invasive method for the diagnosis of non-alcoholic hepatic steatosis.Material and methods.The study involved 21 patients with confrmed non-alcoholic hepatic steatosis on ultrasound examination with an average age of 42.1 ± 10.1 years. The control group consisted of 10 apparently healthy individuals. The following indicators were determined: body mass index (BMI), the level of gamma-glutamyl transpeptidase (GGTP), vasculoendothelial growth factor (VEGF) and interleukin-6 (IL-6) in serum, and the steatosis index (IS) was calculated using the formula IS = –1.2390 + 0.0575 × BMI + 0.0064 × GGTP +0.0006 × VEGF + 0.0001 × IL-6. The index of the presence of hepatic steatosis according to liver ultrasound data was used as a dependent variable.Results.According to the examination results, BMI and serum concentrations of GGTP, VEGF, and IL-6 in patients with steatosis were signifcantly higher than in the control group (p < 0.001, p < 0.001, p < 0.001, and p < 0.001, respectively), which indicates the presence of cholestasis syndrome, signs of inﬂammation and endothelial dysfunction. The correlation coeffcient between BMI and the presence of non-alcoholic hepatic steatosis was 0.9; between GGTP and the presence of steatosis was 0.80; between VEGF and the presence of steatosis was 0.85; between IL-6 and the presence of steatosis was 0.80. The predictive value of each parameter of the model was assessed using a scale of values of the area under the ROC-curve (AUC). The model is effective (multiple correlation coeffcient R = 0.809; the share of the inﬂuence of the sum of the factors included in the model is R2 • 100 = 65.5%), statistically signifcant (criterion F = 12.318; p < 0.0001) and has excellent diagnostic characteristics.Conclusion.The proposed non-invasive method makes it possible to diagnose hepatic steatosis with a sensitivity of 95.2% and a specifcity of 97.0%: with IS equal to 0.5 or more, the presence of non-alcoholic hepatic steatosis is diagnosed, with IS less than 0.5 is not.
Robust Nanofiber Mats Exfoliated From Tussah Silk for Potential Biomedical Applications
Authors: Chen Ming , Qin Jianzhong , Lu Shijun , Zhang Feng , Zuo Baoqi 
Published: December 2021

Nanofibers as elements for bioscaffolds are pushing the development of tissue engineering. In this study, tussah silk was mechanically disintegrated into nanofibers dispersed in aqueous solution which was cast to generate tussah silk fibroin (TSF) nanofiber mats. The effect of treatment time on the morphology, structure, and mechanical properties of nanofiber mats was examined. SEM indicated decreasing diameter of the nanofiber with shearing time, and the diameter of the nanofiber was 139.7 nm after 30 min treatment. These nanofiber mats exhibited excellent mechanical properties; the breaking strength increased from 26.31 to 72.68 MPa with the decrease of fiber diameter from 196.5 to 139.7 nm. The particulate debris was observed on protease XIV degraded nanofiber mats, and the weight loss was greater than 10% after 30 days in vitro degradation. The cell compatibility experiment confirmed adhesion and spreading of NIH-3T3 cells and enhanced cell proliferation on TSF nanofiber mats compared to that on Bombyx mori silk nanofiber mats. In conclusion, results indicate that TSF nanofiber mats prepared in this study are mechanically robust, slow biodegradable, and biocompatible materials, and have promising application in regenerative medicine.
Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis
Authors: Lv Zi , Xiong Li-ling , Qin Xian , Zhang Hua , Luo Xin , Peng Wei , Kilby Mark D. , Saffery Richard , Baker Philip N. , Qi Hong-bo 
Published: December 2021

Graphical AbstractLv et al. show that trophoblastic GRK2 deficiency could promote placenta dysfunction and PE-like phenotype by activating necroptosis in trophoblasts, then inducing cytokine disturbance in circulation.
A Ferroptosis-Related lncRNAs Signature Predicts Prognosis and Therapeutic Response of Gastric Cancer
Authors: Xiao Shilang , Liu Xiaoming , Yuan Lingzhi , Wang Fen 
Published: December 2021

Background: Accumulating literature demonstrates that long noncoding RNAs (lncRNAs) are involved in ferroptosis and gastric cancer progression. However, the predictive value of ferroptosis-related lncRNAs for prognosis and therapeutic response is yet to be elucidated in gastric cancer (GC).Method: The transcriptomic data and corresponding clinical information of GC patients were obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) database. The association between ferroptosis-related lncRNAs and ferroptosis regulators was analyzed by Spearman correlation analysis. Then, we established a risk predictive model based on the ferroptosis-related lncRNAs using multivariate Cox regression analysis. Furthermore, we performed correlation analysis for the risk score and characteristics of biological processes, immune landscape, stromal activity, genomic integrity, drug response, and immunotherapy efficacy.Results: We constructed a 17-ferroptosis-related-lncRNA signature via multivariate Cox analysis to divide patients into two groups: low- and high-risk groups. The low-risk group was linked to prolonged overall survival and relapse-free survival. The risk score had good predictive ability to predict the prognosis of GC patients compared with other clinical biomarkers. We found that the high-risk group was associated with activation of carcinogenetic signaling pathways, including stromal activation, epithelial-mesenchymal-transition (EMT) activation, and immune escape through integrated bioinformatics analysis. In contrast, the low-risk group was associated with DNA replication, immune-flamed state, and genomic instability. Additionally, through Spearman correlation analysis, we found that patients in the high-risk group may respond well to drugs targeting cytoskeleton, WNT signaling, and PI3K/mTOR signaling, and drugs targeting chromatin histone acetylation, cell cycle, and apoptosis regulation could bring more benefits for the low-risk group. The high-risk group was associated with poor immunotherapy efficacy.Conclusion: Our study systematically evaluated the role of ferroptosis-related lncRNAs in t tumor microenvironment, therapeutic response, and prognosis of GC. Risk score–based stratification could reflect the characteristic of biological processes, immune landscape, stromal activity, genomic stability, and pharmaceutical profile in GC patients. The ferroptosis-related lncRNA signature could serve as a reliable biomarker to predict prognosis and therapeutic response of patients with GC.
Exploring the Mechanism of Action of Canmei Formula Against Colorectal Adenoma Through Multi-Omics Technique
Authors: Guo Cui , Liu Xiaoqiang , Xu Yimin , Han Xinyue , Xie Runnan , Meng Xiangxue , Li Yuan , Chen Tongyu , Cheng Zhihong , Fu Xiaoling 
Published: December 2021

Background: Canmei formula (CMF) is a traditional Chinese medicine compound with definite effect on the prevention and treatment of colorectal adenoma (CRA). CMF can prevent the transformation of intestinal inflammation to cancer. This study explored the mechanism of action of CMF in anti-CRA using multi-omics techniques.Method: The mice were randomly divided into four groups: blank group (Control), high-fat diet (HFD) + AOM/DSS colorectal adenoma model (ADH) groups, Canmei formula treatment group (ADH-CMF) and sulfasalazine treatment group (Sul). Except for the blank group, ADH model was established in the other three groups by intraperitoneal injection with AOM reagent, and then mice were given 2.5% DSS in free drinking water and high-fat diet. The mice in the blank group and ADH groups were intragastrically perfused with normal saline, and the mice in the other two groups were treated with corresponding drugs for 20 weeks. During this period, the changes of physical signs of mice in each group were observed. The differentially expressed genes and proteins in the Control group, ADH group and ADH-CMF group were detected by RNA-seq transcriptome sequencing and Tandem Mass Tags (TMT) quantitative proteomics. After the combined analysis and verification, the key targets were analyzed by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Moreover, the changes of intestinal flora in mice of the three groups were examined.Results: A total of 2,548 differential genes were obtained by transcriptomics analysis, and 45 differential proteins were obtained by proteomics analysis. The results of proteomics data and experimental verification showed that CMF mainly affected the Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase (LHPP) target. GO analysis showed that the targets of CMF were involved in the biological processes such as cellular process, metabolic process and biological regulation. KEGG analysis showed that those genes were involved in oxidative phosphorylation, cell senescence, and metabolic pathways. Studies have shown that LHPP overexpression impeded colorectal cancer cell growth and proliferation in vitro, and was associated with a change in PI3K/AKT activity. The results of 16S DNA high-throughput sequencing showed that CMF could effectively regulate the abundance of Bifidobacterium, Candidatus_Saccharimonas and Erysipelatoclostridium in the intestinal flora at the genus level.Conclusion: CMF regulates LHPP via the PI3K/AKT signaling pathway. CMF affects the abundance of specific intestinal flora and can regulate the disorder of intestinal flora to achieve the role of prevention and treatment of CRA.
The Prognostic Value of Lung Ultrasound in Patients With Newly Diagnosed Heart Failure With Preserved Ejection Fraction in the Ambulatory Setting
Authors: Morvai-Illés Blanka , Polestyuk-Németh Nóra , Szabó István Adorján , Monoki Magdolna , Gargani Luna , Picano Eugenio , Varga Albert , Ágoston Gergely 
Published: December 2021

Background: Heart failure with preserved ejection fraction (HFpEF) is a growing healthcare burden, and its prevalence is steadily increasing. Lung ultrasound (LUS) is a promising screening and prognostic tool in the heart failure population. However, more information on its value in predicting outcome is needed.Aims: The aim of our study was to assess the prognostic performance of LUS B-lines compared to traditional and novel clinical and echocardiographic parameters and natriuretic peptide levels in patients with newly diagnosed HFpEF in an ambulatory setting.Methods: In our prospective cohort study, all ambulatory patients with clinical suspicion of HFpEF underwent comprehensive echocardiography, lung ultrasound and NT-proBNP measurement during their first appointment at our cardiology outpatient clinic. Our endpoint was a composite of worsening heart failure symptoms requiring hospitalization or loop diuretic dose escalation and death.Results: We prospectively enrolled 75 consecutive patients with HFpEF who matched our inclusion and exclusion criteria. We detected 11 events on a 26 ± 10-months follow-up. We found that the predictive value of B-lines is similar to the predictive value of NT-proBNP (AUC 0.863 vs. 0.859), with the best cut-off at &gt;15 B-lines. Having more B-lines than 15 significantly increased the likelihood of adverse events with a hazard ratio of 20.956 (p = 0.004). The number of B-lines remained an independent predictor of events at multivariate modeling. Having more than 15 B-lines lines was associated with a significantly worse event-free survival (Log-rank: 16.804, p &lt; 0.001).Conclusion: The number of B-lines seems to be an independent prognostic factor for adverse outcomes in HFpEF. Since it is an easy-to-learn, feasible and radiation-free method, it may add substantial value to the commonly used diagnostic and risk stratification models.
Kinematic Boundary Conditions Favouring Subduction Initiation at Passive Margins Over Subduction at Mid-oceanic Ridges
Authors: Auzemery A. , Willingshofer E. , Yamato P. , Duretz T. , Beekman F. 
Published: December 2021

We perform numerical modelling to simulate the shortening of an oceanic basin and the adjacent continental margins in order to discuss the relationship between compressional stresses acting on the lithosphere and the time dependent strength of the mid-oceanic ridges within the frame of subduction initiation. We focus on the role of stress regulating mechanisms by testing the stress–strain-rate response to convergence rate, and the thermo-tectonic age of oceanic and continental lithospheres. We find that, upon compression, subduction initiation at passive margin is favoured for thermally thin (Palaeozoic or younger) continental lithospheres (&lt;160 km) over cratons (&gt;180 km), and for oceanic basins younger than 60 Myr (after rifting). The results also highlight the importance of convergence rate that controls stress distribution and magnitudes in the oceanic lithosphere. Slow convergence (&lt;0.9 cm/yr) favours strengthening of the ridge and build-up of stress at the ocean-continent transition allowing for subduction initiation at passive margins over subduction at mid-oceanic ridges. The results allow for identifying geodynamic processes that fit conditions for subduction nucleation at passive margins, which is relevant for the unique case of the Alps. We speculate that the slow Africa–Europe convergence between 130 and 85 Ma contributes to the strengthening of the mid-oceanic ridge, leading to subduction initiation at passive margin 60–70 Myr after rifting and passive margin formation.
Noble Metals in Arc Basaltic Magmas Worldwide: A Case Study of Modern and Pre-Historic Lavas of the Tolbachik Volcano, Kamchatka
Authors: Kutyrev Anton , Zelenski Michael , Nekrylov Nikolai , Savelyev Dmitry , Kontonikas-Charos Alkiviadis , Kamenetsky Vadim S. 
Published: December 2021

Platinum-group elements (PGE) and gold are a promising tool to assess the processes of mantle melting beneath the subduction zones. However, fractionation processes in magmas inevitably overwrite the initial metal budgets of magmas, making constraints on the melting processes inconclusive. Moreover, little is still known about the geochemical behavior of a particular metal in a single arc magmatic system, from mantle melting towards magma solidification. Here we compare noble metals in lavas from several eruptions of the Tolbachik volcano (Kamchatka arc) to better understand the effects of magma differentiation, estimate primary melt compositions and make constraints on the mantle melting. We show that Ir, Ru, Rh and, to a lesser extent, Pt are compatible during magmatic differentiation. The pronounced incompatible behavior of Cu and Pd, observed in Tolbachik magmas, rules out the significant influence of sulfide melts on the early magmatic evolution in this particular case. Gold is also incompatible during magmatic differentiation; however, its systematics can be affected by the inferred gold recycling in the plumbing system of Tolbachik. Although the Tolbachik lavas show only slightly higher PGE fractionation than in MORB, a notable negative Ru anomaly (higher Pt/Ru and Ir/Ru) is observed. We attribute this to be a result of greater oxidation in the subarc mantle (by 1–4 log units), which promotes crystallization of Ru-bearing phases such as Fe3+-rich Cr-spinel and laurite. The estimated Pd contents for the parental melt of the Tolbachik lavas approaches 6.5 ppb. This is several times higher than reported MORB values (1.5 ± 0.5 ppb), suggesting the enrichment of Pd in the mantle wedge. Our results highlight the influence of the subduction-related processes and mantle wedge refertilization on the noble metal budgets of arc magmas.
Multi-Step Combined Control Technology for Karst and Fissure Water Inrush Disaster During Shield Tunneling in Spring Areas
Authors: Huang Xing , Li Linfeng , Zhang Chaofan , Liu Bin , Li Kejin , Shi Hongbing , Jing Boyu 
Published: December 2021

Shield tunneling in highly fractured karst water-rich conditions easily results in water inrush disaster or even causes the roof of the karst caves to collapse. Severe water inrush disasters have occurred during the EPB (earth pressure balance) shield machine of the Jinan Metro Line R1 advanced through a karst and fissure groundwater-rich limestone ground in the spring area. To cope with the extreme water inrush risk, a multi-step combined control technology was put forward. First, a detailed geological exploration was carried out by ahead geophysical prospecting using high-density resistivity method, geological radar, etc., and geological borehole drilling was conducted from the ground surface before excavation. As a result, the distribution orientation, size, fissure development degree, and water inflow channel within the surrounding rock of the karst caves were detected. Second, multi-step grouting was performed to reinforce the surrounding rock, including pre-grouting treatment and filling rock blocks to the big karst caves from the ground surface, multiple grouting with a small amount of inert slurry each time inside the tunnel, and secondary circumferential hoop grouting at the shield tail. Third, the tunneling process was optimized, including optimizing the tunneling parameters, making full use of the air-pressurized tunneling technology of the EPB to press bentonite into the fractures around the excavation cabin to seal the fissure water, and using the drainage system of EPB and muck improvement technology to reduce the water inrush disaster. Meanwhile, shield protection slurry technology is applied to cutter inspection and replacement in the pressurized chamber under dynamic water flow environment of the spring terrain. The practice shows that the water inrush on the tunnel face is obviously alleviated after the shield machine advanced into the grouting area. According to statistics, the water inflow on the tunnel face decreases from about 4 m3/h before treatment to less than 0.3 m3/h after the abovementioned control, and the water seepage between the segmental linings reduces to almost zero. The average advance rate increased from 3 m/day without stopping or even zero when the shield machine needs to shut down 2–3 days for drainage to about 6 m/day. In addition, the treatments prevented the shield machine from jamming and the head descending disaster. This study provided a reliable control method for shield tunneling through the karst and fissure water-rich area and played an essential role in protecting the spring water.
Coupling of Anaerobic Digestion and Struvite Precipitation in the Same Reactor: Effect of Zeolite and Bischofite as Mg2+ Source
Authors: Palominos N. , Castillo A. , Guerrero L. , Borja R. , Huiliñir C. 
Published: December 2021

The aim of this research was to assess the simultaneous effect of zeolite and bischofite on estruvite production in an anaerobic digester treating pig slurry as substrate. Three ratios (5:1, 6:1 and 7:1) of Mg-P were used for evaluating the effect of only bischofite on anaerobic digestion. For assessing the simultaneous effect of zeolite and bischofite on anaerobic digestion, three mass ratios of zeolite:bischofite (1, 5 and 10%) were used. As results, bischofite as Mg+2 source served to decrease the total phosphorous (TP) concentration in the anaerobic digestion of pig manure without affecting the maximum methane production rate or methane yield of the system. An average 82.5% TP removal was found in the reactors with bischofite during the first 5 days of digestion. Nevertheless, bischofite increased the lag-phase of the system. The simultaneous presence of zeolite and bischofite (1% ratio with respect to bischofite) caused a TP removal of 65.6% and increased the methane yield by up to 19.9% compared to a system without zeolite or bischofite. Thus, it is feasible to use bischofite and zeolite as enhancers for the simultaneous production of biogas and struvite inside an anaerobic digester treating piggery wastewater.