bluuebunny/crossref_metadata_2025_split huggingface dataset:
Useful experimental aspects of small-wedge synchrotron crystallography for accurate structure analysis of protein molecules
Authors: Hirata Kunio 
Published: December 2024

Recent advances in low-emittance synchrotron X-ray technology and highly sensitive photon-counting detectors have revolutionized protein micro-crystallography in structural biology. These developments and improvements to sample-exchange robots and beamline control have paved the way for automated and efficient unattended data collection. This study analyzed protein crystal structures such as type 2 angiotensin II receptor, CNNM/CorC membrane proteins and polyhedral protein crystals using small-wedge synchrotron crystallography (SWSX), which dramatically improves measurement efficiency through automated measurement. We evaluated the data quality using SWSX, focusing on `massive data collection'. In this context, `massive' refers to data sets with a multiplicity exceeding 100. The findings could potentially lead to the development of more efficient experimental conditions, such as obtaining high-resolution data using a smaller number of crystals. We have demonstrated that the application of machine learning, a modern key component of data science, to classify data groups is an integral part of the analysis process and may play a crucial role in improving data quality. These results indicate that SWSX is one of the essential candidates for crystal structure analysis methods for difficult-to-analyze samples: it can enable diverse and complex protein functional analysis.
The nature and relevance of team grit
Authors: Buchel Paula Audrey , Lew Charlene 
Published: December 2024

Purpose
This research aims to investigate the nature of the team grit construct as distinct from individual grit and determines its relevance within a net of team constructs.

Design/methodology/approach
Using a new, validated and invariant team grit scale, the study confirmed the factor structure of a scale in a United Kingdom sample (n = 228), tested the discriminant nature of individual and team grit and examined relationships between proposed antecedents and outcomes of team grit in a United States sample (n = 269). This paper applied structural equation modeling to analyze the data.

Findings
Results of this paper revealed the relevance of this goal-focused team construct. It showed that team grit is distinct from individual grit and preceded by team psychological safety and team goal commitment, and predicts team innovation, and team work engagement.

Research limitations/implications
The team grit scale used in this study provides new opportunities to understand team grit in organizational settings.

Originality/value
To the best of the authors’ knowledge, this research offers the first empirical investigation of the relationships of team grit in organizations with other team constructs.
Understanding citizen adoption of smart governance: integrating technology acceptance and readiness theories
Authors: Dash Ajitabh 
Published: December 2024

Purpose
This study aims to identify the key factors influencing citizens’ intention to use smart governance services using the amalgamation of the technology acceptance model (TAM) with the theory of technology readiness (TR).

Design/methodology/approach
The convenience sampling method was used to collect data from 260 respondents residing in Indore, Bhubaneswar, Bhopal and Nashik smart cities of India using a questionnaire survey method. The data collected for this study were analyzed using partial least squares structural equation modeling (PLS-SEM) using SmartPLS 4.0.8.9.

Findings
The study’s findings revealed that citizens' discomfort with smart governance services negatively impacts their perceived ease of use and perceived usefulness. Insecurity also reduces perceived ease of use and usefulness. On the other hand, innovativeness associated with these services positively affects perceived ease of use and usefulness. Optimism does not significantly influence these perceptions. It was also revealed that perceived ease of use associated with smart governance services positively impacts perceived usefulness. Finally, perceived ease of use and usefulness significantly affect citizens’ intentions to use these services.

Originality/value
This study uniquely integrates the TAM with the TR to examine the adoption of smart governance in smart cities in India. The findings offer valuable insights for policymakers, highlighting the roles of discomfort, insecurity, innovativeness and optimism in influencing citizens’ perceptions and usage intentions.
Does consumerism increase subjective well-being? The case of Egyptian millennials
Authors: Yassin Donia , Ghoneim Hebatallah 
Published: December 2024

PurposeThis paper aims to study the relationship between consumerism and Subjective Well-being (SWB), exploring to what extent the acquisition of goods contributes to personal happiness and satisfaction. Additionally, it examines the influence of diverse factors like religiosity, marital status, education, age, gender and home ownership, shedding light on their roles in shaping SWB.Design/methodology/approachThis study uses survey data from a sample of the millennial segment in Egypt and employs regression analysis to examine the relationship between consumerism and subjective well-being. To ensure a robust analysis, the researchers categorized SWB into six different categories, and regression analysis was used to test its relation with consumerism and socioeconomic factors.FindingsThe analysis shows a consistent positive correlation between consumerism and SWB. Religiosity and marital status significantly impact SWB, while other socioeconomic factors showed mixed or insignificant effects. This highlights the complex link between materialism, societal values and happiness, suggesting policy opportunities to enhance millennial well-being.Research limitations/implicationsThe findings raise ideas for sustainable consumption practices to enhance SWB, urging collaborative efforts from institutions and policymakers. The study contributes to understanding SWB through Sen’s Capability Approach, emphasizing the importance of freedoms and capabilities beyond material wealth. It provides empirical insights relevant to shaping policy, education and business practices toward enhancing holistic well-being.Originality/valueResearch in the field has rarely investigated the determinants of SWB, especially in a developing country like Egypt. This study has incorporated six different methods to estimate SWB.
Investigation of 3-monochloropropane-1,2-diol and glycidyl ester levels in French fries obtained after frying process using palm olein oil with artificial and natural antioxidants
Authors: Yıldız Kıvılcım , İyilikeden Elif , Yıldız Orçun , Günç Ergönül Pelin 
Published: December 2024

Purpose
3-MCPD (3-monochloropropane-1,2-diol) and glycidyl esters (GE) are process contaminants generated during thermal processing, associated with adverse health effects, including carcinogenicity and genotoxicity. This study aims to investigate the impact of the use of artificial [butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA)] and natural (nettle and olive leaf) antioxidants in palm olein oil during deep-fat frying on the levels of 3-Monochloropropan-1,2-diol (3-MCPD) and GE in French fries samples.

Design/methodology/approach
Artificial antioxidants BHT and BHA, along with natural antioxidants from nettle (Urtica dioica L.) and olive leaf (Olea europaea L. folium) extracts, were incorporated into palm olein oil during deep frying. Frying was conducted repeatedly over a period of three days. The 3-MCPD and GE contents of the oils collected from the French fries during the frying process were quantified using the AOCS analytical method.

Findings
The finding indicated that the levels of 3-MCPD and GE in the french fry samples from groups with both artificial and natural antioxidants were reduced compared to the control group (p < 0.001, p < 0.001; respectively). Upon examination of all data, Nettle extract exhibited the highest level of 3-MCPD ester (1.66 ± 0.01 ppm); whereas the BHT+BHA group demonstrated the lowest level (0.52 ± 0.01 ppm). The analysis of GE levels revealed a maximum of 1.59 ± 0.01 ppm in the control group and a minimum of 1.22 ± 0.34 ppm in the group treated with Nettle extract.

Originality/value
This study assessed the levels of 3-MCPD and GE in repeated deep-frying with palm olein supplemented with olive leaf and nettle extract, a novel investigation to date.
Essentialising teachers' education for inclusive education: The forms, characteristics, and synergies that support capacity building for sustainable inclusive practice
Authors: Ackah‐Jnr Francis R. , Abedi Emmanuel A. , Udah Hyacinth , Ackah Mercy J. 
Published: December 2024

AbstractHow teachers are trained and professionally developed for inclusive education is an important focus of policy, research, and practice. Such preparation arguably affects their knowledge, skills, beliefs, attitudes, and motivation to improve student learning outcomes and transform practice. However, the context and approach to teachers' education for inclusion vary across countries and educational institutions and searching for its effective features remains an unending goal. To capture holistic perspectives on preparing teachers for inclusive education from a non‐Western, developing context, we used a multi‐site case study approach and conducted interviews with headteachers and teachers of early childhood settings and schools. Findings indicate inclusive education‐based training and learning programmes with practical, authentic, and blended characterisations support development of teachers' core knowledge, skills, values, and dispositions. This article also reveals essential synergies among the education programmes that are all requisites enhancing teacher preparedness, currency, and professionalism. The study suggests pre‐service training programmes essentially leverage new learning, knowledge, and capacity acquisition. In concluding, this article calls for rethinking inclusive teacher preparation as continuing synergistic and to attend to contextual influences on it.
What do students with special needs think about their educational environment in Türkiye?
Authors: Ünay Ebru , Erdem Raziye 
Published: December 2024

AbstractThis study aimed to explore the opinions and preferences of students with special needs who receive resource room services. The participants included 113 students aged between 7 and 13 years, and data were collected through a questionnaire that focused on the students' experiences in the resource room. The findings indicate that students require support in academic areas, particularly in Mathematics and Turkish. Additionally, students expressed positive feelings towards studying in the resource room and showed a preference for studying academic subjects in that setting. Overall, this study provides insights into the perspectives of students with special needs who benefit from resource room services. It is crucial to provide flexible opportunities that align with students' preferences, whether it be resource room or general education classes, to develop effective programs for students with special needs. By incorporating students' perspectives and preferences, educational stakeholders can create an inclusive and supportive learning environment that meets the specific needs of students with special needs. The findings contribute to the existing body of knowledge in the field and can inform educational policies and practices aimed at supporting students with special needs.
Associations of clinical parameter‐based accelerated aging, genetic predisposition with risk of chronic kidney disease and associated life expectancy: A prospective cohort study
Authors: Zheng Gang , Chang Qing , Zhang Yixiao , Liu Yashu , Ji Chao , Yang Honghao , Chen Liangkai , Xia Yang , Zhao Yuhong 
Published: December 2024

AbstractLittle evidence exists regarding the associations between clinical parameter‐based biological aging and the incidence and outcome of chronic kidney disease (CKD). Thus, we aimed to assess the associations between biological aging, genetic risk, and the risk of CKD, as well as investigate the impact of accelerated biological aging on life expectancy. 281,363 participants free of kidney diseases from the UK Biobank were included in this prospective study. Biological age was measured from clinical traits using the KDM‐BA and PhenoAge algorithms, and the discrepancies from chronological age were defined as biological age accelerations. A polygenic score was calculated to indicate the genetic predisposition of the estimated glomerular filtration rate (eGFR). A cause‐specific competing risk model was used to estimate hazard ratios (HRs) and the corresponding confidence intervals (CIs) of incident CKD. We found that individuals with more pronounced accelerations in biological age exhibited an elevated risk of developing CKD (HRQuartile 4 vs. Quartile 1, 1.90; 95% CI, 1.77–2.05 for KDM‐BA acceleration and HRQuartile 4 vs. Quartile 1, 2.79; 95% CI, 2.58–3.01 for PhenoAge acceleration), with nonlinear relationships. Notably, there were positive additive interactions between biological aging and genetic risk on CKD risk. Among the CKD population, accelerated biological aging was associated with a further decline in life expectancy. Advanced biological aging may potentially increase the vulnerability to developing CKD in individuals aged midlife and beyond, particularly among those with high genetic risk for abnormal kidney function, and could reduce the life expectancy of CKD patients.
Means Restriction for Suicide Prevention: An Umbrella Review
Authors: Nevarez‐Flores Adriana G. , Pandey Vandana , Angelucci Adriana Perez , Neil Amanda L. , McDermott Brett , Castle David 
Published: December 2024

ABSTRACTObjectiveThe aim of this umbrella review is to summarise existing international evidence on means restriction activities for the prevention of suicide, and provide evidence of their success or lack thereof. The consolidated and integrated information can help inform potential public health interventions.MethodsAn overview of published systematic reviews in English was undertaken. There were no time restrictions. Six major repositories of systematic reviews databases were searched for relevant studies and the reference lists of all selected systematic reviews searched for identifying reviews not retrieved within the database searches. Included studies needed to be Cochrane or non‐Cochrane systematic reviews (with or without meta‐analyses) that explored means restriction activities for suicide prevention.ResultsA total of 670 records were identified across the searches; 11 reviews were eligible for inclusion. Three further reviews were identified through list searches with one eligible for inclusion. Thus, 12 systematic reviews were included in this umbrella review. Activities undertaken around the world were implemented for the prevention of suicide by firearms, jumping from heights and in front of a moving object, and suicide by hazardous agents. A variety of factors associated with the success and/or failure of mean restriction activities were identified, including the prevalence of method and presence or lack of a substitution effect. Most reviews found means restriction activities successful in the prevention of suicide.ConclusionsMeans restriction is an empirically proven strategy that should be considered for the prevention of suicide. Priority should be given to the most prevalent methods of suicide and implementation of locally relevant solutions, including the cultural context of the targeted population. Other important factors such as minimisation of any substitution effect need to be considered when implementing means restriction activities for suicide prevention.
Single‐step genome‐wide association study reveals candidate genes for body mass index trait in Yunong‐black pigs
Authors: Wu Ziyi , Dou Tengfei , Wu Jiahao , Bai Liyao , Zhang Yongqian , Zan Shengyuan , Yang Songbai , Zhou Hao , Han Jinyi , Han Xuelei , Qiao Ruimin , Wang Kejun , Yang Feng , Li Xin‐Jian , Li Xiu‐Ling 
Published: December 2024

AbstractBody mass index (BMI) can serve as a reasonable indicator of overall body fat content in pigs. This study aimed to identify underlying variants and candidate genes associated with BMI in Yunong‐black pigs. A single‐step genome‐wide association analysis (GWAS) was performed on 1405 BMI records and 924 Yunong‐black pigs genotyped using a 50 K SNP Chip. De‐regressed estimated breeding values were taken as the response variable in the GWAS. The estimated heritability for BMI was 0.157. Nine significant regions were associated with BMI, accounting for 12.828% of genetic variance, with the highest region explaining 1.969% of the genetic variance. Linkage disequilibrium analysis of the nine significant regions revealed that SNPs in six single‐step GWAS‐identified genomic regions were all located in the linkage disequilibrium blocks. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of the 29 protein‐coding genes annotated to these regions revealed that FABP2, a key gene associated with BMI in human, was enriched in the fatty acid binding term and the fat digestion and absorption pathway. This study provides a better insight into the genetic architecture of the BMI trait, and offers potential molecular markers for the breeding of Yunong‐black pigs.
CXCL10 Promotes Spinal Macrophage Recruitment via the JAK/STAT3 Pathway to Induce Pain in Experimental Autoimmune Prostatitis
Authors: Chen Lei , Chen Ziqi , Chen Jia , Du Hexi , Chen Xianguo , Chen Jing , Wang Hui , Liang Chaozhao 
Published: December 2024

ABSTRACTThe aim is to explore the mechanisms underlying pain development in chronic prostatitis and identify therapeutic targets for pain management in patients with chronic prostatitis. RNA sequence of the spinal cord dorsal horns and proteomic analysis of spinal macrophages of experimental autoimmune prostatitis (EAP) mice were conducted to identify pain‐related genes, proteins and signalling pathways. The clodronate liposome, CXCR3 and P‐STAT3 inhibitors, NGF antibody and cromolyn sodium were used to investigate the roles of the CXCL10/CXCR3, JAK/STAT3 and NGF/TrKA pathways in spinal macrophage recruitment and pain response. Finally, prostate tissues from benign prostate hyperplasia (BPH) patients were collected to validate the aforementioned results. Neuron and astrocyte‐derived CXCL10 was associated with spinal macrophage recruitment, and CXCL10/CXCR3 axis could regulate the chemotaxis of macrophage to the spinal cord in EAP mice. Results of proteomic analysis found that CXCL10 could regulate the JAK/STAT3 pathway to mediate neuroinflammation in EAP, which was validated in vivo and in vitro experiments. The number of mast cells and expressions of NGF, TrKA and PGP9.5 increased in the prostates of EAP mice and BPH patients, and targeting NGF could reduce spinal macrophage recruitment and pain response. NGF was the triggering factor to induce chemotaxis of spinal macrophages and neuroinflammation, and the CXCL10/CXCR3 axis and JAK/STAT3 pathway was involved in spinal macrophage recruitment and infiltration, which provided therapeutic targets for pain management.
“Being With” as the Center and Circumference of Teaching
Authors: Hansen David T. 
Published: December 2024

AbstractIn this article, David Hansen works with two conceptions of “being with.” The first is Jean‐Luc Nancy's ontological version as found in his Being Singular Plural (1999). The second is Hansen's ontic formulation as expressed in his recent book, Reimagining the Call to Teach: A Witness to Teachers and Teaching (2021). Nancy's notion is ethical as well as ontological. It constitutes a vision of human being qua being and is formulated in critical juxtaposition with the viewpoints on ethics and being of Martin Heidegger and other recent thinkers. Hansen's conception is not ontological, as such, but is ethical in the sense of presuming that teaching is a practice with built‐in terms of relationship between teachers, students, and the subject matter of education, where “education” differs from socialization and enculturation. “Being with” constitutes a term of art for the priority in teaching of attunement, responsiveness, and receptivity — both to students and to subject matter — over formal processes of teacher reflection. The latter are indispensable, but they take their identity and their warrant from the fundamental ethical terms of the practice that are rooted in being with. Here, Hansen seeks to show how Nancy's conception of being with enriches the pedagogical idea of being with as the center and circumference of teaching.
Effects of physical therapy on health‐related quality of life in patients with haemophilia: A systematic review and meta‐analysis
Authors: Chen Chien‐Min , Liu Shang‐Lin , Shie Mu‐Ching 
Published: December 2024

AbstractIntroductionPhysical therapy benefits patients with haemophilia (PWH), but its impact on the health‐related quality of life (HRQOL) remains unclear.AimThis systematic review and meta‐analysis investigated the association of physical therapy, including therapeutic exercise, manual therapy, and physical agent modality, with HRQOL improvement in PWH.MethodsDatabases PubMed, Embase, MEDLINE, and Scopus were searched from inception until April 2024. This review included randomised controlled trials (RCTs) that compare the HRQOL between the physical therapy and control groups. Relevant data and outcome values of included study were collected. Cochrane collaboration's tool and the grading of recommendations, assessment, development, and evaluation approach were used for risk of bias (ROB) and evidence‐level assessment, individually.ResultsThe systematic review included eight RCTs that involved 298 male PWH. The meta‐analysis for HRQOL improvement revealed a significant difference in favour of physical therapy (standardised mean difference [SMD] = .92; 95% confidence interval [CI]:.50–1.33; p < .001). Therapeutic exercise exhibited more benefits in HRQOL improvement than the control groups (SMD = 1.02; 95% CI:.49–1.55; p < .001). Physical therapy effectively improved HRQOL in PWH with better joint status (SMD = 1.74; 95% CI:.97–2.51; p < .001). Of the eight RCTs, six were rated as high ROB. The comparisons revealed a moderate certainty of evidence.ConclusionsPhysical therapy, especially therapeutic exercise, effectively improved the HRQOL of PWH. Maintaining better joint status and timely physical therapy intervention is crucial for HRQOL improvements in PWH. Cautious interpretation is required due to evidence limitations.