bluuebunny/crossref_metadata_2025_split huggingface dataset:
As She Lay Dying: Locating the Gothic in Kaui Hart Hemmings’s The Descendants
Authors: Hodge Amber P. 
Published: March 2021

Abstract
This essay seeks to expand the scope of both US southern and Pacific Islander American studies by examining The Descendants (2007) in conversation with William Faulkner’s southern gothic mainstay As I Lay Dying (1930). The essay positions Hemmings’s novel in a gothic framework to reveal connections across regional gothics in the United States and expose colonial legacies. The enduring trauma of British imperialism is well-documented, but American colonialism, particularly in Hawai‘i, is rarely addressed in the continental United States, making a gothic “recontextualization” especially necessary. Both Hemmings and Faulkner interrogate the pressures the dead—both recent and ancestral—place on the living by deploying gothic tonality to illuminate social problems. In aligning gothic forms, this essay examines the literary representations of twenty-first-century plantation inheritances from the southernmost US state, Hawai‘i, and the southeastern United States. Ultimately, I argue that vestiges of the wrongs borne of their plantation origins, in both the southeastern United States and Hawai‘i, manifest across gothic forms in distress surrounding land and legacy as well as in an emphasis on futurity—all grounded in the maternal.
Science Fiction and Utopia in the Anthropocene
Authors: Canavan Gerry 
Published: March 2021

Abstract
This article takes up science-fictional visions of the future against the “deep time” of the Anthropocene in order to explore the possibilities for utopia that remain in an era that only seems capable of producing necrofuturological dread. The piece surveys a wide range of contemporary literature and film; the key prose authors discussed are Octavia E. Butler, Margaret Atwood, Ernest Callenbach, and Kim Stanley Robinson. These texts are used to identify patterns of thought that have become habitual in the cultural moment of the Anthropocene, and they are explored as critiques of, alternatives to, and lines of flight away from its more pessimistic ideological formations.
Expansion and innovation in auxin signaling: where do we grow from here?
Authors: Ramos Báez Román , Nemhauser Jennifer L. 
Published: March 2021

ABSTRACT
The phytohormone auxin plays a role in almost all growth and developmental responses. The primary mechanism of auxin action involves the regulation of transcription via a core signaling pathway comprising proteins belonging to three classes: receptors, co-receptor/co-repressors and transcription factors. Recent studies have revealed that auxin signaling can be traced back at least as far as the transition to land. Moreover, studies in flowering plants have highlighted how expansion of the gene families encoding auxin components is tied to functional diversification. As we review here, these studies paint a picture of auxin signaling evolution as a driver of innovation.
TGFβ family signaling and development
Authors: Jia Shunji , Meng Anming 
Published: March 2021

ABSTRACT
The transforming growth factor β (TGFβ) signaling family is evolutionarily conserved in metazoans. The signal transduction mechanisms of TGFβ family members have been expansively investigated and are well understood. During development and homeostasis, numerous TGFβ family members are expressed in various cell types with temporally changing levels, playing diverse roles in embryonic development, adult tissue homeostasis and human diseases by regulating cell proliferation, differentiation, adhesion, migration and apoptosis. Here, we discuss the molecular mechanisms underlying signal transduction and regulation of the TGFβ subfamily pathways, and then highlight their key functions in mesendoderm induction, dorsoventral patterning and laterality development, as well as in the formation of several representative tissues/organs.
Inferring cell junction tension and pressure from cell geometry
Authors: Roffay Chloé , Chan Chii J. , Guirao Boris , Hiiragi Takashi , Graner François 
Published: March 2021

ABSTRACTRecognizing the crucial role of mechanical regulation and forces in tissue development and homeostasis has stirred a demand for in situ measurement of forces and stresses. Among emerging techniques, the use of cell geometry to infer cell junction tensions, cell pressures and tissue stress has gained popularity owing to the development of computational analyses. This approach is non-destructive and fast, and statistically validated based on comparisons with other techniques. However, its qualitative and quantitative limitations, in theory as well as in practice, should be examined with care. In this Primer, we summarize the underlying principles and assumptions behind stress inference, discuss its validity criteria and provide guidance to help beginners make the appropriate choice of its variants. We extend our discussion from two-dimensional stress inference to three dimensional, using the early mouse embryo as an example, and list a few possible extensions. We hope to make stress inference more accessible to the scientific community and trigger a broader interest in using this technique to study mechanics in development.
PAPOLA contributes to cyclin D1 mRNA alternative polyadenylation and promotes breast cancer cell proliferation
Authors: Komini Chrysoula , Theohari Irini , Lambrianidou Andromachi , Nakopoulou Lydia , Trangas Theoni 
Published: March 2021

ABSTRACTPoly(A) polymerases add the poly(A) tail at the 3′ end of nearly all eukaryotic mRNA, and are associated with proliferation and cancer. To elucidate the role of the most-studied mammalian poly(A) polymerase, poly(A) polymerase α (PAPOLA), in cancer, we assessed its expression in 221 breast cancer samples and found it to correlate strongly with the aggressive triple-negative subtype. Silencing PAPOLA in MCF-7 and MDA-MB-231 breast cancer cells reduced proliferation and anchorage-independent growth by decreasing steady-state cyclin D1 (CCND1) mRNA and protein levels. Whereas the length of the CCND1 mRNA poly(A) tail was not affected, its 3′ untranslated region (3′UTR) lengthened. Overexpressing PAPOLA caused CCND1 mRNA 3′UTR shortening with a concomitant increase in the amount of corresponding transcript and protein, resulting in growth arrest in MCF-7 cells and DNA damage in HEK-293 cells. Such overexpression of PAPOLA promoted proliferation in the p53 mutant MDA-MB-231 cells. Our data suggest that PAPOLA is a possible candidate target for the control of tumor growth that is mostly relevant to triple-negative tumors, a group characterized by PAPOLA overexpression and lack of alternative targeted therapies.
AMP-activated protein kinase is a key regulator of acute neurovascular permeability
Authors: Dragoni Silvia , Caridi Bruna , Karatsai Eleni , Burgoyne Thomas , Sarker Mosharraf H. , Turowski Patric 
Published: March 2021

ABSTRACT
Many neuronal and retinal disorders are associated with pathological hyperpermeability of the microvasculature. We have used explants of rodent retinae to study acute neurovascular permeability, signal transduction and the role of AMP-activated protein kinase (AMPK). Following stimulation with either vascular endothelial growth factor (VEGF-A) or bradykinin (BK), AMPK was rapidly and strongly phosphorylated and acted as a key mediator of permeability downstream of Ca2+. Accordingly, AMPK agonists potently induced acute retinal vascular leakage. AMPK activation led to phosphorylation of endothelial nitric oxide synthase (eNOS, also known as NOS3), which in turn increased VE-cadherin (CDH5) phosphorylation on Y685. In parallel, AMPK also mediated phosphorylation of p38 MAP kinases (hereafter p38) and HSP27 (HSPB1), indicating that it regulated paracellular junctions and cellular contractility, both previously associated with endothelial permeability. Endothelial AMPK provided a missing link in neurovascular permeability, connecting Ca2+ transients to the activation of eNOS and p38, irrespective of the permeability-inducing factor used. Collectively, we find that, due to its compatibility with small molecule antagonists and agonists, as well as siRNA, the ex vivo retina model constitutes a reliable tool to identify and study regulators and mechanisms of acute neurovascular permeability.
Imperatyw konkretyzacji
Authors: Luboń Arkadiusz 
Published: March 2021

Imperative of Concretization: Translational Shifts and the Models of Reception of Howard Phillips Lovecraft’s Prose – The Case Study of "The Outsider" and its Polish Versions
The Article discusses translational reception of Howard Phillips Lovecraft’s prose in Poland on the example of his short story The Outsider. The gothic tale of a mysterious recluse visiting human society, in its original version, has no explicit interpretation due to the fact that the maincharacter’s identity is intentionally left by Lovecraft without precise and unambiguous explanation for its readers to determine. Polish versions, however, modified in the process of interlinguistic transfer, are aimed at concretization of the text, and thus solving this interpretational puzzle with different answers given by five translators (Grzegorz Iwanciw, Robert Lipski, Ewa Morycińska-Dzius, Mateusz Kopacz and Maciej Płaza), influenced by a variety of factors: image of the American writer, knowledge of his other literary works, implied readers of the translations and artistic trends popular in Polish literature.
Powtórzenie w oryginale, powtórzenie w przekładzie
Authors: Mitura Magdalena 
Published: March 2021

Repetition in Original Work, Repetition in Translation: Remarks onthe Phenomenon of Repetition on the Example of Dukla by Andrzej Stasiuk and Its French Translation
The objective of the present article is to analyze the translational solutions applied to repetitions in the French translation of the Dukla novel by Andrzej Stasiuk. Based on the classification elaborated by Adam Dobaczewski (2018), we diversified two groups in the selected Polish materials: intra-sentence repetitions and inter-sentence repetitions. The intra-sentence repetitions were then divided into two subgroups. The first one included systemic repetitions, i.e. those that were the predetermined code units of the respective language. The other subgroup included supra-language operations, which were the result of text-creative mechanisms that were independent from the specific language system. The results of our analysis undermine the existing belief that supra-langue repetitions are easily translatable. Even when these elements are not subject to potential blocking by limitations of grammar, their translation – or more frequently – disappearance, depend on stylistic considerations and/or arbitrary decisions madeby the translator.
The Bigger Picture: Combining Econometrics with Analytics Improves Forecasts of Movie Success
Authors: Lehrer Steven F. , Xie Tian 
Published: March 2021

There exists significant hype regarding how much machine learning and incorporating social media data can improve forecast accuracy in commercial applications. To assess if the hype is warranted, we use data from the film industry in simulation experiments that contrast econometric approaches with tools from the predictive analytics literature. Further, we propose new strategies that combine elements from each literature in a bid to capture richer patterns of heterogeneity in the underlying relationship governing revenue. Our results demonstrate the importance of social media data and value from hybrid strategies that combine econometrics and machine learning when conducting forecasts with new big data sources. Specifically, although both least squares support vector regression and recursive partitioning strategies greatly outperform dimension reduction strategies and traditional econometrics approaches in forecast accuracy, there are further significant gains from using hybrid approaches. Further, Monte Carlo experiments demonstrate that these benefits arise from the significant heterogeneity in how social media measures and other film characteristics influence box office outcomes. This paper was accepted by J. George Shanthikumar, big data analytics.
AN ANALYSIS OF AN EAP COURSE BOOK USED IN ISLAMIC HIGHER EDUCATION
Authors: Fikry Fikry 
Published: March 2021

Selecting EAP Course book which is suitable for Islamic Studies students is not an easy job to handle. To know the strengths and weaknesses of the course book, there should be an evaluation. This study evaluates English Textbook, Islamic Learning in EAP which is designed for undergraduate students learning Islamic Studies at Islamic Higher Education. Two points were addressed in this study: (1) has the content of textbook meet the criteria of Language teaching principles? (2) has the textbook followed proper EAP materials and tasks?This is a qualitative research with content analysis method. The data was the textbook of Islamic Learning in EAP by Ahwy Oktradiksa (2013). The content of course book was analyzed based on principles of language teaching by Paul Nation (2010) and design of EAP materials and tasks by Stoller (2016). The findings reveal the strengths and weaknesses of Islamic Learning in EAP. This study indicates that (1) the course book has poor quality and has not met the criteria of language teaching principles covering: (a) content and sequencing, (b) format and presentation, (c) monitoring and assessment; (2) the course book does not cover the content of EAP materials and tasks. It tends to present general English and does not stimulate to develop language and academic skills, critical thinking skills, introduce technology into learning activities and do not provide with some strategies to English test skills like TOEFL or IELTS. This study will contribute significantly to curriculum and materials developers, teachers, and students interested in EFL learning.
DEVELOPING ESP READING COMPREHENSION INSTRUCTIONAL MATERIALS THROUGH SCHEMA THEORY APPROACH AT PAI STUDY PROGRAM OF TARBIYAH FACULTY OF IAIN BENGKULU
Authors: Rizal Syamsul 
Published: March 2021

The fact that the English reading comprehension ability of the students of Islamic Religious Education of Tarbiyah Faculty of IAIN Bengkulu is still low. One of the causes of the problem is the ineffectiveness of the English teaching materials that have been used. Therefore, the purpose of this study is to produce ESP English reading comprehension instructional materials based on Islamic Educational Studies (IES) in accordance with the characteristics of Islamic Education Study Program students of Tarbiyah Faculty. The procedure in developing this instructional materials was adapted from Borg and Gall's research and development model. The research method used to investigate the effectiveness of the product is quasi-experimental method. The developed instructional material prototype was validated by material and media experts and also by English lecturers. According to experts of material and media, the product is very good with the percentage of ideality of 76% and 73.3%. According to the English lecturers’ validations are also categorized in good category with 77.5% percentage and the students' responses from the aspect of material, presentation and language assessment are classified as positive (good) category. There is a significant difference of reading comprehension achievement between experimental and control group students. It means that the students’ reading comprehension ability in the experimental group is higher than that of in the control group. It indicates that the product of this research is effective in improving the students’ English reading comprehension achievement.
An analysis of Indonesian literary translation ‘Pena Beracun’ by Suwarni A.S. from Agatha Christie’s novel The Moving Finger
Authors: Suharjono Sigit 
Published: March 2021

The work of translation is not a matter of only transferring words from one language to another. It is a communication bridge through which a translator must pick up and carry the message of the whole text that the writer is trying to communicate in the given situation of the source-text readers and deliver it to the target-text readers in their adopted and adapted situation. This is the point at which a translator often misses what is in the writer’s mind because s/he is unable to get into the writer’s mind to reveal the hidden message. As a result, the way the readers of the target text think and feel about what they read is often not the same as the way the readers of the source text do. This paper is aimed at finding out problems related to non-equivalence from the word level to the pragmatic level based on Baker’s that may be found in a literary translation of the first chapter of Pena Beracun by Suwarni A.S from Agatha Christie’s novel ‘The Moving Finger” and discusses the translator’s choices of the target text equivalence for the source text. The method of this study is a library research. The data was collected from two sources: Pena Beracun, an Indonesian translation of ‘The Moving Finger’ by Agatha Christie and its original English novel. The data collection technique was done by comparing the two sources to find non-equivalence problems from the word level to the textual level. The problem(s) in the translator’s choice of TL equivalence for SL, which may range from choosing the equivalence at word level to the choice of textual equivalence was identified and discussed by referring to the strategies as proposed by Baker (2011). Lots of cases of non-equivalence problems are found in the translation of the first chapter Pena Beracun by Suwarni A.S from Agatha Christie’s novel ‘The Moving Finger’ which range from non-equivalence at word level to textual level. Most of the problems of non-equivalence are related to collocation and fixed expressions. The translator’s strategies to overcome the problems are directed more to the acceptability and naturalness in the target language, giving style to the literary use of language.
Characterization of the position of the extraocular muscles and orbit in acquired esotropia both at distance and near using orbital magnetic resonance imaging
Authors: Kawai Manami , Goseki Toshiaki , Ishikawa Hitoshi , Tatsui Sonoko , Li Hongyang , Ukisu Ryutaro , Shoji Nobuyuki 
Published: March 2021

PurposeAge-related distance esotropia (ARDE) involves acquired esotropia at distance and phoria at near. However, distance-independent esotropia (DIE) exists esotropia both at distance and near. Thus, we examined the orbital magnetic resonance imaging (MRI) findings for DIE to assess differences in its characteristics.MethodsThis study was a retrospective case-control study. We evaluated the efficacy of the standard coronal MRI in patients with acquired esotropia and control patients with optic neuritis. Cases with strabismus in the control group were excluded. DIE was defined as having esotropia both at distance and near, and an angle of more than 10 prism diopters at near. The condition of the lateral rectus-superior rectus band, position of rectus muscles, and the volume ratio of the globe to the whole orbit (G/WO) were examined.ResultsThe DIE group consisted of 12 eyes of 6 patients (77.3±7.7 years); ARDE group, 38 eyes of 19 patients (73.1±6.8 years); and control group, 34 eyes of 17 patients (70.9±4.3 years). The ratio of abnormality of the lateral rectus-superior rectus bands was higher in the DIE and ARDE groups than in the control group (p<0.01). The vertical angle of the lateral rectus deviated downwards in the control (-7.5±5.1°), ARDE (-12.2±9.1°), and DIE groups (-18.8±5.7°) (p<0.05). The tilting angle of the lateral rectus was tilted temporally in the control (-12.2±9.1°), ARDE (-20.0±8.6°) and DIE groups (-28.6±5.4°) (p<0.01). G/WO was higher in the DIE (0.28±0.01) and ARDE groups (0.27±0.02) compared to the control (0.25±0.03) group (p<0.01).ConclusionIn comparison with the ARDE and control groups, the DIE group presented with abnormalities of the lateral rectus-superior rectus band, malposition of the lateral rectus, and differences in the G/WO. The DIE group showed a more severe form of ARDE.
Sala de aula invertida: reconstruindo o processo de ensino e de aprendizagem por meio de uma metodologia ativa
Authors: Silva Claudia Maria Bezerra da 
Published: March 2021

A proposta da sala de aula invertida é a de que o aluno tenha o primeiro contato com o conteúdo previamente Ã aula. A sala de aula passa a ser o local para esclarecer dúvidas e aprofundar o conhecimento em atividades práticas como resolução de problemas, projetos e discussão em grupo. Este artigo apresenta uma revisão da literatura que tem como objetivo refletir sobre a sala de aula invertida como metodologia ativa e as mudanças e os impactos da sua utilização para o processo de ensino e de aprendizagem. Conclui-se que o propósito da sala de aula invertida é favorecer uma melhor utilização do tempo e espaço em sala, incentivando o aluno ativo, com pensamento reflexivo e a maior interação entre os alunos e desses com o professor. Isso pode levar a impactos positivos, como a maior compreensão conceitual, desenvolvimento do pensamento crÃ­tico e redução no número de reprovações. Por outro lado, pontos negativos podem surgir, como aumento da carga horária de estudo prévio e dificuldade do aluno em se adaptar Ã lógica da inversão das aulas.
The employment policy and vocational activity support system for people with intellectual disabilities in Poland: emancipation policy or apparent actions?
Authors: Woynarowska Agnieszka 
Published: March 2021

This article presents problematics related to social policy and the system supporting the vocational activity of persons with intellectual disabilities in Poland. Analyses aimed at finding an answer to the question posed in the title are based on the results of a research project entitled Employment and disability. An analysis of the vocational experience of people with intellectual disabilities in Poland, which aimed at an exploration of the policy of the employment of persons with disabilities, practices in the area of employment services, and a reconstruction of the experience of subjects involved in the work situation: job coaches, persons with intellectual disabilities, and coordinators of employment projects. The methodological framework of the project was provided by the grounded theory set in social constructivism as presented in Charmaz’s works. The research material was collected in 25 workplaces employing persons with disabilities in various parts of Poland, mainly by means of in-depth interviews, observation, and field notes. The paper presents only a small fragment of the research results. The analyses focus on the presentation of the assumptions, goals, and trends of the employment policy, ways of functioning of the system of support of the vocational activity of persons with intellectual disabilities, and the confrontation of these systemic assumptions with the experience of persons involved in the implementation of this employment policy in the Polish reality. The article is therefore a critical analysis of the current policy of the employment of persons with intellectual disabilities, unmasking the existing paradoxes and apparent actions in the system of vocational support and the labour market
Jogkorlátozás és jogfosztás a gazdasági életben a Pécsi Királyi Törvényszék gyakorlata alapján (1938–1944)
Authors: Herger Csabáné 
Published: March 2021

The goal of this study, based on the remained documents of the cases started in 1942 at the Royal Tribunal of Pécs, is to examine the legal disputes concerning contracts of sales which does and does not constitute commercial transactions in the southern Transdanubia, Baranya county, Hungary, and how the right restrictions and deprivations of the Horthy era appeared in them. The study also aims to show the types of crimes connected to commercial activities which were partially created by the extraordinary legislation as a result of the war.