bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of psychopathology and shame on social representations of health and lifestyle behaviours via free association: a graph analysis approach
Authors: Briseniou Evangelia , Skenteris Nikolaos , Hatzoglou Chryssi , Tsitsas George , Diamantopoulos Epaminondas , Dragioti Elena , Gouva Mary 
Published: October 2021

Abstract
Background
There is a knowledge gap in whether psychopathology aspects can shape and mark the social representations about health and lifestyle. In this work, we investigated the association of psychopathology and shame with the centrality of the words describing eight common social representations of health and lifestyle.

Methods
A convenience sample of 288 adults participated with an average age of 44.7, and 62.6% were women. The participants were asked to express three consecutive words associated with eight different health and lifestyle experiences by utilizing the free association method. The participants also were completed the Symptom Checklist-90-Revised (SCL-90-R), the Experiences of Shame Scale (ESS), and the Other as Shamer Scale (OAS). Canonical correlation analysis was applied to investigate the relationship between the set of the eight-word centralities and the psycho-demographic variables consisting of the subject's age and gender, the SCL 90 subscales, the OAS, and the ESS. Based on these findings, a structural equation explorative model was formed to test the unidimensionality of the five centralities construct.

Results
Τhe psychological characteristics of interpersonal sensitivity, depression, external shame, and hostility were found to affect the word selection process on the social representations concerning nightlife, health, diet, lifestyle, and alcohol consumption. Participants with increased levels of depression tend to choose more centrally positioned words when the stimulus word was diet and more decentralized responses when the stimulus word was health. At the same time, higher external shame corresponded to more decentralized words for the categories of health and lifestyle.

Conclusions
Our results indicate that there is a potential interaction between the psychological state and how a social representation of health and lifestyle is constructed through selected words. Graph theory emerged as an additional tool to use to study these relations.
A novel SMARCA2-CREM fusion: expanding the molecular spectrum of intracranial mesenchymal tumors beyond the FET genes
Authors: Tauziède-Espariat Arnault , Pierron Gaëlle , Guillemot Delphine , Sievers Philipp , Cazals-Hatem Dominique , Faillot Thierry , Roux Alexandre , Benzakoun Joseph , Bockel Sophie , Weinbreck Nicolas , Hasty Lauren , Lechapt Emmanuèle , Chrétien Fabrice , Varlet Pascale 
Published: October 2021

AbstractA novel histomolecular tumor of the central nervous system, the “intracranial mesenchymal tumor (IMT), FET-CREB fusion-positive” has recently been identified in the literature and will be added to the 2021 World Health Organization Classification of Tumors of the Central Nervous System. However, our latest study using DNA-methylation analyses has revealed that intracranial FET-CREB fused tumors do not represent a single molecular tumor entity. Among them, the main subgroup presented classical features of angiomatoid fibrous histiocytoma, having ultrastructural features of arachnoidal cells, for. Another tumor type with clear cell component and histopathological signs of aggressivity clustered in close vicinity with clear cell sarcoma of soft tissue. Herein, we report one case of IMT with a novel SMARCA2-CREM fusion which has until now never been described in soft tissue or the central nervous system. We compare its clinical, histopathological, immunophenotypic, genetic and epigenetic features with those previously described in IMT, FET-CREB fusion-positive. Interestingly, the current case did not cluster with IMT, FET-CREB fusion-positive but rather presented histopathological (clear cell morphology with signs of malignancy), clinical (with a dismal course with several recurrences, metastases and finally the patient’s death), genetic (fusion implicating the CREM gene), and epigenetic (DNA-methylation profiling) similarities with our previously reported clear cell sarcoma-like tumor of the central nervous system. Our results added data suggesting that different clinical and histomolecular tumor subtypes or grades seem to be included within the terminology “IMT, FET-CREB fusion-positive”, and that further series of cases are needed to better characterize them.
Time to think beyond door to balloon time: significance of total ischemic time in STEMI
Authors: Khowaja Sanam , Ahmed Salik , Kumar Rajesh , Shah Jehangir Ali , Khan Kamran Ahmed , Khan Naveed Ullah , Saghir Tahir , Rizvi Syed Nadeem Hasan , Qamar Nadeem , Karim Musa 
Published: October 2021

Abstract
Background
Significance of total ischemic time (TIT) in the context of ST-segment elevation myocardial infarction (STEMI) is still controversial. Therefore, in this study, we have evaluate the association of TIT with immediate outcomes in STEMI patients in whom recommended door to balloon (DTB) time of less than 90 min was achieved.

Results
A total of 5730 patients were included in this study, out of which 80.9% were male and median age was 55 [61–48] years. The median DTB was observed to be 60 [75–45] min and onset of chest pain to emergency room (ER) arrival time was 180 [300–120] min. Prolonged TIT was associated with poor pre-procedure thrombolysis in myocardial infarction (TIMI) flow grade (p = 0.022), number of diseased vessels (p = 0.002), use of intra-aortic balloon pump (p = 0.003), and in-hospital mortality (p = 0.002). Mortality rate was 4.5%, 5.7%, and 7.8% for the patients with TIT of ≤ 120 min, 121 to 240 min, and > 240 min, respectively. Thirty days’ risk of mortality on TIMI score was 4.97 ± 7.09%, 5.01 ± 6.99%, and 7.12 ± 8.64% for the patients with TIT of ≤ 120 min, 121 to 240 min, and > 240 min, respectively.

Conclusions
Prolonged total ischemic was associated with higher in-hospital mortality. Therefore, TIT can also be considered in the matrix of focus, along with DTB time and other clinical determinants to improve the survival from STEMI.
Computational insight to design new potential hepatitis C virus NS5B polymerase inhibitors with drug-likeness and pharmacokinetic ADMET parameters predictions
Authors: Ejeh Stephen , Uzairu Adamu , Shallangwa Gideon A. , Abechi Stephen E. 
Published: October 2021

Abstract
Background
Hepatitis C virus (HCV) is considered a worldwide health problem since it affects over 3% of the population and causes 300,000 fatalities per year. Chronic infection causes high morbidity and mortality in patients, leading to liver cirrhosis, hepatocellular carcinoma, fibrosis, liver cancer, and other HCV-related illnesses. Finding novel and better HCV treatments is a top international health goal right now. As a result, the pressing need for new HCV antiviral drugs has fueled research into the structural requirements of NS5B polymerase inhibitors at a molecular basis.

Results
In this study, an in silico technique was applied to study 79 compounds with HCV inhibitory bioactivity, with the best statistical results ($$R^{2}$$

R
2

= 0.7051, $$Q^{2}$$

Q
2

= 0.6455, $$R_{{{\text{pred}}}}^{2}$$

R

pred

2

= 0.6992, $$^{{\text{c}}} R_{{\text{r}}}^{2}$$

c

R

r

2

= 0.6570, SEE = 0.2694).

Conclusions
This QSAR investigation allowed the research team to evaluate the influence of straightforward descriptors, shedding insight into the critical elements that guide the design of innovative effective molecules. Most of the innovative effective molecules exhibited better binding affinity (− 195.6 kcal/mol) than dasabuvir the reference drug (− 171.0 kcal/mol) with the target receptor (hepatitis C virus NS5B RNA polymerase). ADMET prediction disclosed enhanced pharmacokinetic properties with lower MRTD (maximum tolerated dose) of some new derivatives.
Facing the Past
Authors: Aslan Nora Tataryan 
Published: October 2021

Abstract
Through a consideration of three film works—Ravished Armenia/Auction of Souls (1919), Testimony (2007), and Remembering (2019), which all represent the testimonies of Armenian women to form truths of the catastrophe—this article problematizes how such portrayals might, contrary to their best intentions, resonate with the logic of genocide. By discussing specific woman figures in the three works, published at three times in the postgenocidal era—one just after the events, the other two recently—this article aims not only to mark the evolution of the representational regime with which the Armenian woman is surrounded but also to show that this phenomenon is a key component in a transformation of the lexicon developed around the recognition politics, which ought to involve something other than feverishly chasing a representation of the events of 1915–17 and using women’s witness narratives to this end.
A magnet attached to the forehead disrupts magnetic compass orientation in a migratory songbird
Authors: Packmor Florian , Kishkinev Dmitry , Bittermann Flora , Kofler Barbara , Machowetz Clara , Zechmeister Thomas , Zawadzki Lucinda C. , Guilford Tim , Holland Richard A. 
Published: October 2021

ABSTRACT
For studies on magnetic compass orientation and navigation performance in small bird species, controlled experiments with orientation cages inside an electromagnetic coil system are the most prominent methodological paradigm. These are, however, not applicable when studying larger bird species and/or orientation behaviour during free flight. For this, researchers have followed a very different approach, attaching small magnets to birds, with the intention of depriving them of access to meaningful magnetic information. Unfortunately, results from studies using this approach appear rather inconsistent. As these are based on experiments with birds under free-flight conditions, which usually do not allow exclusion of other potential orientation cues, an assessment of the overall efficacy of this approach is difficult to conduct. Here, we directly tested the efficacy of small magnets for temporarily disrupting magnetic compass orientation in small migratory songbirds using orientation cages under controlled experimental conditions. We found that birds which have access to the Earth's magnetic field as their sole orientation cue show a general orientation towards their seasonally appropriate migratory direction. When carrying magnets on their forehead under these conditions, the same birds become disoriented. However, under changed conditions that allow birds access to other (i.e. celestial) orientation cues, any disruptive effect of the magnets they carry appears obscured. Our results provide clear evidence for the efficacy of the magnet approach for temporarily disrupting magnetic compass orientation in birds, but also reveal its limitations for application in experiments under free-flight conditions.
Rh-PVP Catalyzed Reductive Amination of Phenols by Ammonia or Amines to Cyclohexylamines under Solvent-free Conditions
Authors: Chaudhari Chandan , Sato Katsutoshi , Rumi Saeki , Nishida Yoshihide , Shiraishi Masaya , Nagaoka Katsutoshi 
Published: October 2021

Abstract
Colloidal metal nanoparticles were examined for reductive amination of phenol by ammonia under mild reaction conditions. The results showed that Rh-PVP was the most active catalyst for reductive amination reaction. Linear, cyclic, and amino alcohols were used as nucleophiles and converted to primary/secondary/tertiary amines. Using this strategy, the synthesis of an industrially important chemical, N-cyclohexyl-2-pyrrolidone was explored.
Profiles of inflammatory markers and their association with cardiometabolic parameters in rural and urban Uganda
Authors: Sanya Richard E. , Nalwoga Angela , Grencis Richard K. , Elliott Alison M. , Webb Emily L. , Andia Biraro Irene 
Published: October 2021

Background: Inflammation may be one of the pathways explaining differences in cardiometabolic risk between urban and rural residents. We investigated associations of inflammatory markers with rural versus urban residence, and with selected cardiometabolic parameters previously observed to differ between rural and urban residents: homeostatic model assessment of insulin resistance (HOMA-IR), fasting blood glucose (FBG), blood pressure (BP) and body mass index (BMI). Methods: From two community surveys conducted in Uganda, 313 healthy individuals aged ≥ 10 years were selected by age- and sex-stratified random sampling (rural Lake Victoria island communities, 212; urban Entebbe municipality, 101). Fluorescence intensities of plasma cytokines and chemokines were measured using a bead-based multiplex immunoassay. We used linear regression to examine associations between the analytes and rural-urban residence and principal component analysis (PCA) to further investigate patterns in the relationships. Correlations between analytes and metabolic parameters were assessed using Pearson’s correlation coefficient. Results: The urban setting had higher mean levels of IL-5 (3.27 vs 3.14, adjusted mean difference [95% confidence interval] 0.12[0.01,0.23] p=0.04), IFN-⍺ (26.80 vs 20.52, 6.30[2.18,10.41] p=0.003), EGF (5.67 vs 5.07, 0.60[0.32,0.98] p<0.00001), VEGF (3.68 vs 3.28, 0.40[0.25,0.56] p<0.00001), CD40 Ligand (4.82 vs 4.51, 0.31[0.12, 0.50] p=0.001) and Serpin-E1 (9.57 vs 9.46, 0.11[0.05,0.17] p<0.00001), but lower levels of GMCSF (2.94 vs 3.05, -0.10[-0.19,-0.02] p=0.02), CCL2 (2.82 vs 3.10, -0.45[-0.70,-0.21] p<0.00001) and CXCL10 (5.48 vs 5.96, -0.49[-0.71,-0.27] p<0.00001), compared to the rural setting. In PCA, the urban setting had lower representation of some classical inflammatory mediators but higher representation of various chemoattractants and vasoactive peptides. HOMA-IR, FBG, BP and BMI were positively correlated with several principal components characterised by pro-inflammatory analytes. Conclusions: In developing countries, immunological profiles differ between rural and urban environments. Differential expression of certain pro-inflammatory mediators may have important health consequences including contributing to increased cardiometabolic risk observed in the urban environment.
The effect of static stretching of agonist and antagonist muscles on knee joint position sense
Authors: Oskouei Sanam Tavakkoli , Abazari Roya , Kahjoogh Mina Ahmadi , Goljaryan Sakineh , Zohrabi Samane 
Published: October 2021

Background/Aims Proprioception acuity is important in sports activities and stretching is widely used in warm-up programmes. The main objective of this study was to evaluate if a warm-up programme with and without stretching flexors and extensors muscles could affect knee joint position sense. Methods The effects of different stretching regimens on joint position sense were examined. A total of 12 semi-professional football players completed four warm-up sessions over 4 weeks: standard warm-up programme; standard warm-up programme with quadriceps stretching; standard warm-up programme with hamstring stretching; and standard warm-up programme with stretching of both quadriceps and hamstrings. Open kinetic chain knee joint position sense was estimated from the ability to reproduce the three target angles (20°, 45° and 60° knee flexion) in the dominant limb before and after the intervention. Results In the absolute angular error, there was a statistically significant three-way interaction between the warm-up programme, target angle and time (F (6, 54)=6.88, P=0.001). Findings of post-hoc analysis demonstrated that there was a statistically significant difference between the pre- and post-stretching of hamstrings for the target angles of 20° (4.70 vs 1.57, P=0.01), 45° (1.70 vs 4.50, P=0.02), and 60° (1.93 vs 4.20, P=0.02). In the relative angular error, interaction of time by the warm-up programme was significant (F (3, 27)=3.41, P=0.03). Conclusions The warm-up programme with static stretching of hamstrings had a negative effect on open kinetic chain knee joint position sense during the flexion to extension repositioning task, which may not only have a negative effect on performance of athletes as a part of warm-up exercises, but may also lead to further injuries.
Fiber-optic Michelson magnetic field sensor based on a mechanical amplifier structure
Authors: Feng Xinxing , Jiang Yi , Zhang Han 
Published: October 2021

A magnetic field sensor based on a mechanical amplifier structure is proposed and experimentally demonstrated. The sensor is composed of a

3

×

3

coupler-based Michelson interferometer. The magnetic field transducer is a mechanical amplifier structure, in which a TbDyFe rod is wrapped by the polarization-maintaining (PM) fiber. The deformation produced by the TbDyFe rod is amplified and transferred to the PM fiber, causing the fiber length to change. The time-varying phase shift caused by the applied magnetic field is recovered by a passive demodulation method. Experimental results show that the average magnetic field sensitivity of the sensor is 0.4471 V/µT (rms), corresponding to a phase shift sensitivity of 0.2581 rad/µT (rms) and minimum detectable magnetic field of 0.0755 nT/

√

Hz (rms). The maximum response time is 22.77 ms. The proposed magnetic sensor has a simple design with fast response time and is preferable for detecting weak magnetic fields.
Misinformation, perceptions towards COVID-19 and willingness to be vaccinated: A population-based survey in Yemen
Authors: Bitar Ahmad Naoras , Zawiah Mohammed , Al-Ashwal Fahmi Y. , Kubas Mohammed , Saeed Ramzi Mukred , Abduljabbar Rami , Jaber Ammar Ali Saleh , Sulaiman Syed Azhar Syed , Khan Amer Hayat 
Published: October 2021

Background
Since the beginning of the COVID-19 outbreak, many pharmaceutical companies have been racing to develop a safe and effective COVID-19 vaccine. Simultaneously, rumors and misinformation about COVID-19 are still widely spreading. Therefore, this study aimed to investigate the prevalence of COVID-19 misinformation among the Yemeni population and its association with vaccine acceptance and perceptions.

Methods
A cross-sectional online survey was conducted in four major cities in Yemen. The constructed questionnaire consisted of four main sections (sociodemographic data, misinformation, perceptions (perceived susceptibility, severity, and worry), and vaccination acceptance evaluation). Subject recruitment and data collection were conducted online utilizing social websites and using the snowball sampling technique. Descriptive and inferential analyses were performed using SPSS version 27.

Results
The total number of respondents was 484. Over 60% of them were males and had a university education. More than half had less than 100$ monthly income and were khat chewers, while only 18% were smokers. Misinformation prevalence ranged from 8.9% to 38.9%, depending on the statement being asked. Men, university education, higher income, employment, and living in urban areas were associated with a lower misinformation level (p <0.05). Statistically significant association (p <0.05) between university education, living in urban areas, and being employed with perceived susceptibility were observed. The acceptance rate was 61.2% for free vaccines, but it decreased to 43% if they had to purchase it. Females, respondents with lower monthly income, and those who believed that pharmaceutical companies made the virus for financial gains were more likely to reject the vaccination (p <0.05).

Conclusion
The study revealed that the acceptance rate to take a vaccine was suboptimal and significantly affected by gender, misinformation, cost, and income. Furthermore, being female, non-university educated, low-income, and living in rural areas were associated with higher susceptibility to misinformation about COVID-19. These findings show a clear link between misinformation susceptibility and willingness to vaccinate. Focused awareness campaigns to decrease misinformation and emphasize the vaccination’s safety and efficacy might be fundamental before initiating any mass vaccination in Yemen.
Barriers and facilitators to infection prevention and control in Dutch residential care facilities for people with intellectual and developmental disabilities: A theory-informed qualitative study
Authors: Houben Famke , van Hensbergen Mitch , Den Heijer Casper D. J. , Dukers-Muijrers Nicole H. T. M. , Hoebe Christian J. P. A. 
Published: October 2021

Background
Care institutions are recognised to be a high-risk setting for the emergence and spread of infections and antimicrobial-resistant organisms, which stresses the importance of infection prevention and control (IPC). Accurate implementation is crucial for optimal IPC practice. Despite the wide promotion of IPC and research thereof in the hospital and nursing home setting, similar efforts are lacking in disability care settings. Therefore, this study aimed to assess perceived barriers and facilitators to IPC among professionals working at residential care facilities (RCFs) for people with intellectual and developmental disabilities (IDD), as well as to identify professional-reported recommendations to improve IPC.

Methods
This qualitative study involved semi-structured interviews (before COVID-19) with twelve professionals from five Dutch RCFs for people with IDD. An integrated theoretical approach was used to inform data collection and analysis. Thematic analysis using inductive and deductive approaches was conducted. This study followed the COnsolidated criteria for REporting Qualitative research (COREQ) guidelines.

Results
Our findings revealed barriers and facilitators at the guideline, client, professional, professional interaction, professional client interaction, client interaction, organisational, community, and societal level. Six main themes covering multiple barriers and facilitators were identified: (1) guidelines’ applicability to (work)setting; (2) professionals’ cognitions and attitude towards IPC (related to educational background); (3) organisational support and priority; (4) educational system; (5) time availability and staff capacity; and (6) task division and change coaches. The main professional-reported recommendations were the introduction of tailored and practical IPC guidelines, structural IPC education and training among all professionals, and client participation.

Conclusions
To promote IPC, multifaceted and multilevel strategies should be implemented, with a preliminary need for improvements on the guideline, professional, and organisational level. Given the heterogeneous character, i.e., different professionals, clients and care needs, there is a need for a tailored approach to implement IPC and sustain it successfully in disability care. Our findings can inform future IPC practice improvements.