bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penanaman Karakter Anak Usia Dini melalui Lagu Anak-anak Daerah Lampung
Authors: Suri Dharlinda 
Published: August 2021

Saat ini sangat sedikit sekali anak-anak yang bisa menyanyikan lagu-lagu anak daerah Lampung.Anak-anak cenderung menyanyikan lagu-lagu yang sedang populer salah satunya lagu soundtrex film. Penelitian ini bertujuan untuk menanamkan nilai-nilai karkater pada anak usia dini melalui lagu anak-anak daerah lampung. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif. Adapun Teknik analisis data dalam penelitian yaitu dengan menggunakan teknik deskriptif dengan membuat gambaran yang dilakukan dengan cara pengumpulan data, reduksi data, penyajian data, dan kesimpulan. Berdasarkan hasil penelitian serta pembahasan dapat disimpulkan bahwa nilai-nilai Pendidikan karakter pada lagu anak-anak daerah lampung yang berjudul cinta Tuhan segenap ciptaannya, Kutak mainan, sanak santun, dan sanak teghtib, seperti: religius, disiplin, mandiri, tanggungjawab, sopan santun, hormat, jujur, dan bijaksana. Melalui lagu-lagu anak daerah anak mampu mengenal, mengetahui, dan mempunyai rasa cinta daerah serta tanah air
Pengembangan Media Busy Book dalam Pembelajaran Motorik Halus Anak Usia 4-5 Tahun
Authors: Fitriyah Qonitah Faizatul , Purnama Sigit , Febrianta Yudha , Suismanto Suismanto , ‘Aziz Hafidh 
Published: August 2021

Penggunaan media dalam proses pelaksanaan pembelajaran dapat menjadi solusi dalam keefektifan perkembangan motorik halus pada anak dengan jenis RnD atau Reserach and Development menggunakan model Borg and Gall, teknik anallisis data diperoleh data hasil validasi instrumen berupa data deskriptif oleh para ahli, yitu ahli media, ahli materi dan user. Hasil ini adalah media busy book mendapatkan penilaian dari ahli materi yang menunjukkan kriteria sangat baik menunjukkan presentase 82%. Skor oleh ahli media dengan kriteria sangat baik dengan presentase 92%. Uji coba lapangan produk media busy book diujikan kepada 8 peserta didik ant class (Kelompok A) dan direspon oleh guru kelas serta pendidik sebagai user di TK Ceria Demangan Yogyakarta, hasil dari tahap uji coba menunjukkan 50% anak didik mendapatkan kategori “Sangat Baik” dan 50% anak didik mendapatkan kategori “Baik”. Kesimpulannya adalah media bermain busy book layak digunakan
Ekobójstwo i grzech ekologiczny: dwa terminy – dwa porządki – wspólna sprawa
Authors: Bar O. Wiesław 
Published: August 2021

Apel papieża Franciszka – skierowany 15 listopada 2019 r. do uczestników XX Kongresu Międzynarodowego Stowarzyszenia Prawa Karnego – o prawną ochronę środowiska, w tym karną przez uznanie ekobójstwa na całym świecie za przestępstwo ścigane i karane został przez adresatów przyjęty jako mocne wspar­cie podejmowanych przez nich inicjatyw w tym zakresie. Synteza dotychczaso­wych wysiłków oraz trudności we wprowadzaniu adekwatnej do sytuacji regu­lacji międzynarodowej przedstawione zostały w p. 1 artykułu.
W tym samym przemówieniu Franciszek zapowiedział aktywną współpracę Kościoła, m.in. wprowadzenie do Katechizmu Kościoła Katolickiego pojęcia grze­chu ekologicznego. W p. 2 artykułu przeprowadzono krytykę terminu w aspekcie logicznym, językowym, odkrywając pierwotne wyrażenie z pism L. Boffa (grzech anytekologiczny), aktualne nauczanie papieży oraz termin użyty przez profesora prawa karnego L. Aroyyo Zapatero – grzech ekobójstwa.
Correlation of manual semi-quantitative and automated quantitative Ki-67 proliferative index with OncotypeDXTM recurrence score in invasive breast carcinoma
Authors: Finkelman Brian S. , Meindl Amanda , LaBoy Carissa , Griffin Brannan B. , Narayan Suguna P. , Brancamp Rachel , Siziopikou Kalliopi P. , Pincus Jennifer L. , Blanco, Jr. Luis Z. 
Published: August 2021

BACKGROUND: Ki-67 immunohistochemistry (IHC) staining is a widely used cancer proliferation assay; however, its limitations could be improved with automated scoring. The OncotypeDXTM Recurrence Score (ORS), which primarily evaluates cancer proliferation genes, is a prognostic indicator for breast cancer chemotherapy response; however, it is more expensive and slower than Ki-67. OBJECTIVE: To compare manual Ki-67 (mKi-67) with automated Ki-67 (aKi-67) algorithm results based on manually selected Ki-67 “hot spots” in breast cancer, and correlate both with ORS. METHODS: 105 invasive breast carcinoma cases from 100 patients at our institution (2011–2013) with available ORS were evaluated. Concordance was assessed via Cohen’s Kappa (κ). RESULTS: 57/105 cases showed agreement between mKi-67 and aKi-67 (κ 0.31, 95% CI 0.18–0.45), with 41 cases overestimated by aKi-67. Concordance was higher when estimated on the same image (κ 0.53, 95% CI 0.37–0.69). Concordance between mKi-67 score and ORS was fair (κ 0.27, 95% CI 0.11–0.42), and concordance between aKi-67 and ORS was poor (κ 0.10, 95% CI −0.03–0.23). CONCLUSIONS: These results highlight the limits of Ki-67 algorithms that use manual “hot spot” selection. Due to suboptimal concordance, Ki-67 is likely most useful as a complement to, rather than a surrogate for ORS, regardless of scoring method.
Invasive ductal carcinoma mammographic findings: Correlation with age, breast composition and tumor size
Authors: Cerimele Federico , Tagliati Corrado , Salvatori Fabio , Baldassarre Silvia , Di Martino Antonietta , Calamita Valentina , Pressanti Gabriella Lucidi , Mingliang Ying , Giuseppetti Gian Marco , Giovagnoni Andrea 
Published: August 2021

BACKGROUND/OBJECTIVE: The aim of this study was to identify the mammographic findings associated with malignancy in different age groups, taking into account breast composition (BC) and lesion size. METHODS: Preoperative mammograms of 1023 invasive ductal carcinomas were retrospectively evaluated. According to the American College of Radiology Breast Imaging Reporting and Data System, cancer mammographic findings were classified as mass, calcifications, architectural distortion and asymmetry, and breasts were assessed as non-dense (A or B BC) and dense (C or D BC). Patient cohort was subdivided into three age groups (group 1: <50 years of age; group 2: between 50 and 69; group 3: ≥70 years of age). RESULTS: Significant results of multinomial logistic regression were the association between mass and non-dense breast (p < 0.0001) and the association between mass and tumor size larger than 15 mm (p = 0.0049). CONCLUSIONS: Mass finding of invasive ductal breast carcinoma is associated with breast composition and tumor size.
CD274 (PD-L1) Copy Number Changes (Gain) & Response to Immune Checkpoint Blockade Therapy in Carcinomas of the Urinary Tract
Authors: Gupta Sounak , Vanderbilt Chad M. , Zhang Yanming , Tickoo Satish K. , Fine Samson W. , Gopalan Anuradha , Chen Ying-Bei , Sirintrapun Sahussapont J. , Teo Min Yuen , Funt Samuel A. , Iyer Gopa , Rosenberg Jonathan E. , Bajorin Dean F. , Bochner Bernard H. , Pietzak Eugene J. , Ross Dara S. , Ladanyi Marc , Cheville John C. , Solit David B. , Reuter Victor E. , Al-Ahmadie Hikmat A. 
Published: August 2021

BACKGROUND: Immune checkpoint inhibitors are an important therapeutic option for urothelial carcinoma, but durable responses are achieved in a minority of patients. Identifying pre-treatment biomarkers that may predict response to these therapies or who exhibit intrinsic resistance, is of paramount importance. OBJECTIVE: To explore the prevalence of PD-L1 copy number alteration in urothelial carcinoma and correlate with response to immune checkpoint inhibitors. METHODS: We analyzed a cohort of 1050 carcinomas of the bladder and upper urinary tract that underwent targeted next generation sequencing, prospectively. We assessed PD-L1 protein expression, copy number status (next generation sequencing/FISH), and detailed treatment response. RESULTS: We identified 9 tumors with PD-L1 amplification and 9 tumors with PD-L1 deletion. PD-L1 protein expression was the highest in PD-L1 amplified tumors. Of the 9 patients whose tumors harbored PD-L1 amplification, 6 received immunotherapy with 4 deriving clinical benefit, and 2 achieving durable response. Of the 9 patients whose tumors had PD-L1 copy number losses, 4 received immunotherapy with 3 experiencing disease progression. CONCLUSIONS: PD-L1 copy number alterations may serve as potential biomarkers of response to immunotherapy in urothelial carcinoma patients, if validated in larger cohorts.
Identification of a Novel Ferroptosis-Related Gene Signature for Prediction of Prognosis in Bladder Urothelial Carcinoma
Authors: Shi Xiaokai , Zhou Xiao , Zhang Lei , Yue Chuang , Gao Shenglin , Cheng Jiasheng , Zuo Li , Zhang Lifeng 
Published: August 2021

BACKGROUND: sBladder urothelial carcinoma is the most prevalent type of bladder cancer, characterized by drug resistance, high recurrence rate, and unfavorable prognosis. Ferroptosis is a newly discovered type of non-apoptotic cell death, which has been reported to be strongly correlated with tumor occurrence and development. OBJECTIVE: In this study, we characterized ferroptosis-specific biomarkers to elucidate the association between ferroptosis-related genes (FRGs) and bladder urothelial carcinoma. METHODS: The TCGA and GEO database were adopted to obtain data and corresponding clinicopathological information. Univariate and multivariate cox regression were performed to establish a ferroptosis-related model. Besides, the KM plot visualized prognosis between high risk and low risk groups. Moreover, cBioportal platform was used to gather information on genetic alteration and DNA methylation of hub FRGs in BLCA patients. Additionally, the GSEA software was used to detect the difference in gene expression between high-risk and low-risk subgroups. RESULTS: Six ferroptosis-related genes were identified to be highly correlated with overall survival. Besides, we explored the genetic variations of these FRGs, as well as the correlation between FRG expression and copy number values. Additionally, the DNA methylation status of these FRGs was determined. Moreover, we constructed a ferroptosis risk model with the six FRGs to predict the prognosis of BLCA. The results demonstrated that a higher risk score indicated an unfavorable prognosis. The ferroptosis signature was associated with clinical and molecular characteristics and could be regarded as an independent prognostic factor for BLCA patients. CONCLUSIONS: In summary, we established and verified a ferroptosis risk model which had the potential to independently predict the prognosis of bladder urothelial carcinoma.
Simultaneous Exercise and Cognitive Training in Virtual Reality Phase 2 Pilot Study: Impact on Brain Health and Cognition in Older Adults1
Authors: Sakhare Ashwin , Stradford Joy , Ravichandran Roshan , Deng Rong , Ruiz Julissa , Subramanian Keshav , Suh Jaymee , Pa Judy 
Published: August 2021

Background: Aerobic exercise and environmental enrichment have been shown to enhance brain function. Virtual reality (VR) is a promising method for combining these activities in a meaningful and ecologically valid way. Objective: The purpose of this Phase 2 pilot study was to calculate relative change and effect sizes to assess the impact of simultaneous exercise and cognitive training in VR on brain health and cognition in older adults. Methods: Twelve cognitively normal older adults (64.7±8.8 years old, 8 female) participated in a 12-week intervention, 3 sessions/week for 25–50 minutes/session at 50–80% HRmax. Participants cycled on a custom-built stationary exercise bike while wearing a VR head-mounted display and navigating novel virtual environments to train spatial memory. Brain and cognitive changes were assessed using MRI imaging and a cognitive battery. Results: Medium effect size (ES) improvements in cerebral flow and brain structure were observed. Pulsatility, a measure of peripheral vascular resistance, decreased 10.5% (ES(d) = 0.47). Total grey matter volume increased 0.73% (ES(r) = 0.38), while thickness of the superior parietal lobule, a region associated with spatial orientation, increased 0.44% (ES(r) = 0.30). Visual memory discrimination related to pattern separation showed a large improvement of 68% (ES(ηp2) = 0.43). Cognitive flexibility (Trail Making Test B) (ES(r) = 0.42) and response inhibition (ES(W) = 0.54) showed medium improvements of 14% and 34%, respectively. Conclusions: Twelve weeks of simultaneous exercise and cognitive training in VR elicits positive changes in brain volume, vascular resistance, memory, and executive function with moderate-to-large effect sizes in our pilot study.
Three Corporate Finance Practices in Pakistan: A Review of Previous Studies and Way Forward
Authors: Farooq Umar , Subhani Bilal Haider 
Published: August 2021

This study reviews the empirical studies arranged on Pakistani capital market and specifies the pattern of three corporate finance practices. The subject of corporate finance discusses the various activities performed at firm level such as capital budgeting, capital structure, and dividend payout policy. The capital budgeting technique consists of six methods i.e., net present value, discounted cash flow, payback period, and internal rate of return etc. but Pakistani firms often interested in net present value and internal rate of return for capital investment evaluation. Similarly, the capital structure decision carries the debate on two options of financing i.e., debt financing and equity financing but literature shows that the Pakistani firms generally follow the pecking order theory and prefer more debt financing. Similarly, as for concern dividend payout policy, literature discusses the different theories and determinants but still unable to generalize the dividend payout trend specifically in Pakistani context. Corporate managers and policymakers can use the conclusion for strategic purposes.
The association of smoking status with SARS-CoV-2 infection, hospitalisation and mortality from COVID-19: A living rapid evidence review with Bayesian meta-analyses (version 12)
Authors: Simons David , Shahab Lion , Brown Jamie , Perski Olga 
Published: August 2021

AIMS: To estimate the association of smoking status with rates of i) infection, ii) hospitalisation, iii) disease severity in hospitalised patients, and iv) mortality from SARS-CoV-2/COVID-19 disease.

DESIGN: Living rapid review of observational and experimental studies with random-effects hierarchical Bayesian meta-analyses. Published articles and pre-prints were identified via MEDLINE and medRxiv

.

SETTING: Community or hospital. No restrictions on location.

PARTICIPANTS: Adults who received a SARS-CoV-2 test or a COVID-19 diagnosis.

MEASUREMENTS: Outcomes were SARS-CoV-2 infection, hospitalisation, disease severity and mortality stratified by smoking status. Study quality was assessed (i.e. ‘good,’ ‘fair’ and ‘poor’).

FINDINGS: v12 (searches up to 2021-07-18) included 547 studies with 87 ‘good’ and ‘fair’ quality studies included in unadjusted meta-analyses. 171 studies (31.3%) reported current, former and never smoking status with the remainder using broader categories. Recorded smoking prevalence among people with COVID-19 was generally lower than national prevalence. Current compared with never smokers were at reduced risk of SARS-CoV-2 infection (RR = 0.67, 95% Credible Interval (CrI) = 0.60-0.75, τ = 0.27). Data for former smokers were inconclusive (RR = 0.99, 95% CrI = 0.94-1.05, τ = 0.12) but favoured there being no important association (<1% probability of RR ≥1.1). Former compared with never smokers were at increased risk of hospitalisation (RR = 1.27, CrI = 1.15-1.40, τ = 0.20), greater disease severity (RR = 1.69, CrI = 1.30-2.22, τ = 0.43) and mortality (RR = 1.59, CrI = 1.34-1.89, τ = 0.37). Current compared with never smokers were at increased risk of greater disease severity (RR 1.3, 95% CrI = 1.01-1.71, τ = 0.32). Data for current smokers on hospitalisation and mortality were inconclusive (RR = 1.10, 95% CrI = 0.97-1.24, τ = 0.23; RR = 1.13, 95% CrI = 0.90-1.40, τ = 0.41, respectively) but favoured there being no important associations (50% and 60% probability of RR ≥1.1, respectively).

CONCLUSIONS: Compared with never smokers, current smokers appear to be at reduced risk of SARS-CoV-2 infection and increased risk of greater in-hospital disease severity, while former smokers appear to be at increased risk of hospitalisation, greater in-hospital disease severity and mortality from COVID-19. However, it is uncertain whether these associations are causal. This version (v12) will be the last regular update; however, yearly updates may continue as new evidence becomes available.

v7 of this living review article has been published in _Addiction_ [https://doi.org/10.1111/add.15276]
Praktek Pengembangan Bagi Hasil Peternakan Sapi Masyarakat Kecamatan Barebbo Kabupaten Bone Sulawesi Selatan
Authors: Marzuki Sitti Nikmah 
Published: August 2021

Abstrak. Praktek Pengembangan Bagi Hasil Peternakan Sapi Masyarakat Kecamatan Barebbo Kabupaten Bone Sulawesi Selatan. Praktik bagi hasil peternakan masyarakat masih sering terjadi permasalahan yang muncul karena sistem bagi hasil yang tidak jelas, seperti halnya jika terjadi peristiwa force majeur pada saat perjanjian bagi hasil. Misalnya terjadi kematian terhadap anak sapi dari hasil peternakan sapi atau induknya sapi yang mengalami kematian. Penelitian ini mengungkap dan menganalisis praktek bagi hasil dan pendapatan masyarakat peternak sapi. Penelitian ini menggunakan teknik pengumpulan data melalui observasi dan wawancara dengan analisis deskriptif kualitatif. Praktek pengembangan bagi hasil peternakan sapi di Kecamatan barebbo Sistem peternakan sapi di Kecamatan Barebbo pada umumnya menggunakan tiga sistem yaitu teknik pemeliharaan ekstensif, teknik pemeliharaan intensif dan teknik pemeliharaan semiintensif dengan pendapatan peternak rata 2.000.000 – Rp. 5.000.000 setiap satu ekor sapi tergantung dari kondisi sapi dan teknik bagi hasil yang disepakati. Jika peternak melakukan kerjasama ternak sapi 2 sapi maka peternak akan memiliki keuntungan yang lebih besar. Sistem bagi hasil didasarkan pada yang dilakukan Sistem bagi hasil yang diterapkan berdasarkan pendapatan, bagi hasil berdasarkan laba kotor dan bagi hasil berdasarkan laba bersih. Sistem bagi hasil yang paling dominan digunakan oleh masyarakat peternak sapi di Kecamatan Barebbo adalah bagi hasil berdasarkan laba kotor. Sistem ini dipandang lebih adil dan memberikan mashlahah kepada kedua belah pihak. Sistem ini dapat meningkatkan ekonomi masyarakat peternak di Kecamatan Barebbo Kabupaten Bone.
Strategi Pengembangan Wakaf Produktif untuk Kesejahteraan Umat
Authors: Utami Anisa Fitria 
Published: August 2021

Abstract. The Strategy Of Productive Waqf Management For General Welfare (Case Study On Nadzir Of Malang Islamic University Foundation). The purpose of this research is to find out the strategy of productive waqf management for general welfare that conducted by The Nadzir of Universitas Islam Malang Foundation. Malang City still has a quite high poverty rate that is 4,6%. Waqf is an instrumen in islamic economy that can solve poverty beside zakat. The development of waqf in Malang City is increased every year plus there are many waqf asset that spreaded in all sub-district in Malang City. The Nadzir of Universitas Islam Malang Foundation that domiciled in Malang City was given funds by Kementrian Agama with waqf fund agreement. The purpose of that waqf fund is as the example on productive waqf management. The Nadzir of Universitas Islam Malang Foundation has succeed in developing eleven VIP Rooms in UNISMA Hospital. 70% from the outcomes of that management, are used to development and management of the VIP Rooms and used to develop a minimarket that spreaded in several regions. 20% from the outcomes of productive waqf management was channeled to the 40 mauquf alaih periodically. Abstrak. Strategi Pengelolaan Wakaf Produktif untuk Kesejahteraan Umat (Studi Kasus di Nadzir Yayasan Universitas Islam Malang). Penelitian ini bertujuan untuk mengetahui strategi pengelolaan wakaf produktif untuk kesejahteraan umat yang dilakukan oleh Nadzir Yayasan Universitas Islam Malang. Kota Malang masih memiliki tingkat kemiskinan yang cukup tinggi yaitu sebesar 4,6 %. Wakaf merupakan salah satu instrumen dalam ekonomi islam yang mampu mengatasi kemiskinan selain zakat. Perkembangan wakaf di Kota Malang semakin meningkat tiap tahunnya ditambah banyak aset wakaf yang tersebar di seluruh kecamatan di Kota Malang. Nadzir Yayasan Universitas Islam Malang yang berkedudukan di Kota Malang diberi dana oleh Kementrian Agama dengan akad dana wakaf. Tujuan dari dana wakaf tersebut adalah sebagai percontohan dalam pengelolaan wakaf secara produktif. Nadzir Yayasan Universitas Islam Malang telah berhasil membangun Ruang VIP di Rumah Sakit UNISMA sebanyak 11 kamar, 70% dari hasil pengelolaan tersebut digunakan untuk pengembangan dan pengelolaan Ruang VIP serta digunakan untuk membangun minimarket yang tersebar di beberapa daerah. 20% hasil pengelolaan wakaf produktif disalurkan kepada sekitar 40 mauquf alaih secara periodik.
FACTORS INFLUENCING WILLINGNESS TO CONTRIBUTE IN CASH WAQF: CASE OF SOUTH TANGERANG, INDONESIA
Authors: Ahmad Hudzaifah 
Published: August 2021

Abstract: Factors Influencing Willingness to Contribute in Cash Waqf: Case of South Tangerang, Indonesia. Waqf has long been the backbone of community service in Indonesia, especially in the fields of religion and education. Considering the importance of waqf in the socio-economic field in Indonesia, the government expanded the scope of waqf which was originally only in the form of fixed assets and then added with movable assets such as money. As a country with the largest Muslim population in the world, Indonesia has a huge cash waqf potential. But this potential has not been able to be optimized by the government or the private sector. The problem of the lack of awareness of Muslims in Indonesia about cash waqf is the main obstacle. There are several factors that influence one's willingness to do cash waqf, namely knowledge, income, social culture, and promotion. To determine the influence of these factors, the data obtained from respondents from the survey instrument adopted were subjected to descriptive analysis statistical analysis. The findings indicate that all factors significantly affect a person's willingness to do cash waqf. Recommendations contingent on research findings were offered. Abstrak. Faktor-Faktor yang Mempengaruhi Kesediaan untuk Berkontribusi dalam Wakaf Tunai: Kasus Tangerang Selatan, Indonesia. Wakaf telah lama menjadi tulang punggung pengabdian masyarakat di Indonesia, khususnya di bidang agama dan pendidikan. Mengingat pentingnya wakaf dalam bidang sosial ekonomi di Indonesia, pemerintah kemudian memperluas cakupan wakaf yang semula hanya berupa aset tetap menjadi ditambah dengan aset bergerak seperti uang. Sebagai negara dengan populasi Muslim terbesar di dunia, Indonesia memiliki potensi wakaf tunai yang besar. Tetapi potensi ini belum dapat dioptimalkan oleh pemerintah atau sektor swasta. Masalah kurangnya kesadaran umat Islam di Indonesia tentang wakaf tunai adalah kendala utama. Ada beberapa faktor yang mempengaruhi kemauan seseorang untuk melakukan wakaf tunai, yaitu pengetahuan, pendapatan, sosial budaya, dan promosi. Untuk menentukan pengaruh faktor-faktor ini, data yang diperoleh dari responden dari instrumen survei yang diadopsi menjadi sasaran analisis deskriptif analisis statistik. Temuan menunjukkan bahwa semua faktor secara signifikan mempengaruhi kesediaan seseorang untuk melakukan wakaf tunai. Rekomendasi yang bergantung pada temuan penelitian ditawarkan.