bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peguero-Lo Presti criteria for the diagnosis of left ventricular hypertrophy: A systematic review and meta-analysis
Authors: Yu Zongying , Song Jie , Cheng Li , Li Shasha , Lu Qun , Zhang Yafeng , Lin Xiaoci , Liu Dadong 
Published: January 2021

BackgroundThe Peguero-Lo Presti criteria are novel electrocardiographic (ECG) diagnostic criteria for the detection of left ventricular hypertrophy (LVH) and represent the sum of the amplitude of the deepest S wave in any lead with the S wave in lead V4(SD+SV4). The diagnostic efficacy of the Peguero-Lo Presti criteria in LVH is still debatable. We aimed to test the sensitivity and specificity of the Peguero-Lo Presti criteria and compared them with those of the Cornell voltage index to assess their overall performance in LVH diagnosis.MethodsElectronic databases (e.g., Medline, Web of Knowledge, Embase, and the Cochrane Library) were searched from their inception until May 18, 2020. Trials written in English that investigated the Peguero-Lo Presti criteria for detecting LVH were included. Data were independently extracted and analyzed by two investigators.ResultsA total of 51 records were screened, and 6 trials comprising 13,564 patients were finally included. A bivariate analysis showed that the sensitivity of the Peguero-Lo Presti criteria (0.52, 95% confidence interval (CI) 0.46–0.58) was higher than that of the Cornell voltage index (0.29, 95% CI 0.23–0.36) and Sokolow-Lyon criteria (0.24, 95% CI 0.21–0.27); the diagnostic accuracy of the Peguero-Lo Presti criteria (0.69, 95% CI 0.65–0.73) was also higher than that of the Cornell voltage index (0.67, 95% CI 0.62–0.71) and Sokolow-Lyon criteria (0.28, 95% CI 0.25–0.32); and the specificity of the Peguero-Lo Presti criteria (0.85, 95% CI 0.79–0.90) was similar to that of the Cornell voltage index (0.92, 95% CI 0.89–0.95) and Sokolow-Lyon criteria (0.94, 95%CI 0.88–0.97). Two trials (including 12,748 patients) were discharged because they included partly healthy subjects and accounted for substantial heterogeneity. Pooled analysis of the remaining 4 trials (including 816 patients) showed that the sensitivity of the Peguero-Lo Presti criteria (0.56, 95% CI 0.51–0.61) was also higher than that of the Cornell voltage index (0.36, 95% CI 0.31–0.42) and Sokolow-Lyon criteria (0.24, 95% CI 0.18–0.31); the diagnostic accuracy of the Peguero-Lo Presti criteria (0.84, 95% CI 0.80–0.87) was also higher than that of the Cornell voltage index (0.54, 95% CI 0.50–0.58) and Sokolow-Lyon criteria (0.38, 95% CI 0.34–0.42); and the specificity of the Peguero-Lo Presti criteria (0.90, 95% CI 0.87–0.92) was similar to that of the Cornell voltage index (0.93, 95% CI 0.88–0.96) and Sokolow-Lyon criteria (0.97, 95% CI 0.90–0.99). Both the likelihood ratio and posttest probability of the Peguero-Lo Presti criteria and Cornell voltage index were moderate.ConclusionBased on this systematic review and meta-analysis, the Peguero-Lo Presti criteria-based ECG diagnostic method for LVH has high sensitivity, specificity and diagnostic accuracy and should be applied in clinical practice settings.
Unique Case of a Hamartomatous Duodenal Polyp Associated With Intestinal Schistosomiasis
Authors: Gonzalez Adalberto , Gupta Kapil , Rodriguez Sandra , Wadhwa Vaibhav , Bejarano Pablo , Charles Roger 
Published: January 2021

ABSTRACT
Schistosomiasis is a trematode infection rarely diagnosed in the United States. Intestinal involvement is common with chronic infection and causes abdominal pain, changes in bowel habits, hematochezia, and polyp formation. Chronic, disseminated infection can affect the intestines causing the aforementioned symptoms, but reports of intestinal polyps are rare. Most cases are inflammatory fibrous polyps in the colon. There are very few cases reported in the literature of hamartomatous polyps arising in the small intestine. We present the rare case of a U.S.-born, 35-year-old woman diagnosed with a large duodenal hamartomatous polyp in the setting of intestinal schistosomiasis.
Spontaneous Rupture of Gallbladder Hemangioma Presenting as Hemoperitoneum
Authors: Ray Choudhury Satyaprakash , Mohanty Sumit Subhadarshi , Pattanaik Premananda , Lenka Anasuya , Panda Bhagaban 
Published: January 2021

ABSTRACT
Hemangioma of the gallbladder is rare, with less than 10 cases reported in the literature. It may represent a hamartomatous proliferation of connective tissue in the gallbladder or may be congenital in origin. Although liver hemangiomas rarely present with spontaneous rupture, it has not been documented in gallbladder hemangiomas. This report presents a case of gallbladder hemangioma that ruptured spontaneously and presented with hemoperitoneum.
PERAN PERPUSTAKAAN DIGITAL DALAM MENCIPTAKAN RUANG PUBLIK (STUDI KASUS PERPUSTAKAAN DIGITAL UNIVERSITAS LAMPUNG)
Authors: Istiarni Atin , Kurniasari Endah 
Published: January 2021

The purpose of this study is to find out how the information age community understands digital public space and how the role of the University of Lampung's digital library in creating virtual public spaces. This research uses descriptive qualitative research methods. This research builds on the critical theory of public space proposed by Jurgen Habermas and Henry Lefebvre. Data collection through literature study and interviews. Data analysis includes three stages namely data reduction, data presentation, and conclusion or verification. Based on the results of the study, it was found that the public space in the information society is interpreted as a space where there is an infinite process of interaction. The role of the University of Lampung's digital library in creating public spaces includes (1) Providing freedom of access to systems and content, (2) giving freedom of expression to users through communication facilities between users and managers (3) Providing equality for anyone to access and utilize digital library applications The University of Lampung (4) has a legal umbrella in managing digital libraries (5) has a shared commitment to turn the University of Lampung's digital library into an ideal public space. Keywords: Digital Library, Public Spaces, Information Society.
Upaya Mendorong Kolaborasi menuju Pengembangan Struktur Ruang Bernuansa Knowledge Based di Era Disrupsi
Authors: Sutriadi Ridwan , Miftah Ahmad Zaini 
Published: January 2021

This paper explores the development of multi centre urban spatial structures, as the development of three classical models, namely monocentric, sectoral, and multiple nuclei. By implementing a literature study method on studies of the global development of urban spatial structures which began from the 1960s until the 2000s era, lessons learned for Indonesia can be taken in promoting sustainable urban spatial structure. The thought of developing urban spatial structure starts from the awareness of urban expansion beyond its administrative boundaries in the 1960s (urban field), the importance of the systemic context in the development of urban spatial structures (1970s), the systemic concept must be supported by the collaboration of mutual cooperation among city’s functions in the concept of inter-city networks (1980s), spatial planning integration between core cities and suburbs which emerge urban areas (1990s). In 2000s era, the development of polycentric could be located in one urban area or among urban areas, also highly connected with innovation as a reflection of the use of knowledge for urban centers (2010s era). During the decades, it can be concluded that multi city centers lead to the enrichment of urban function in the sense of public interest and common concern, especially symbolizes continuing knowledge based innovation which could interfere market and existing values (disruption era), so collaboration among city centers is needed to perform a sustainable synergic urban spatial structure.
A Comparative Analysis of Carbon Fiber–Reinforced Polymers Subjected to Lightning Damage Tests with Conical Electrodes and Jet Diverting Electrodes
Authors: Chen Jian , Li Zhibao , Fu Zhengcai 
Published: January 2021

Abstract
The results in the damage testing of carbon fiber–reinforced polymers (CFRPs) subjected to simulated lightning strikes are affected by the type of discharge electrodes employed in the laboratory. In this work, two kinds of discharge electrodes, a conical electrode and a jet diverting electrode, were discussed for use in the CFRP-lightning strike testing. The CFRP damage responses to different electrodes were characterized and compared in terms of surface damage area, internal delamination, temperature distribution, pressure distribution, high-temperature gas expansion, and residual flexural strength. The electric arc formed by the conical electrode was more concentrated than that under the jet diverting electrode configuration, thereby producing a smaller surface and internal damage area but a deeper damage depth. The residual mechanical properties of CFRPs tested with the conical electrode decreased significantly under lightning strikes. The discharge channel was uncontrollable by utilizing the jet diverting electrode, and the test results were more dispersed than the results under the conical electrode, which was not conducive to the damage analysis or the repetition of testing. Therefore, the conical electrode is recommended in CFRP-lightning damage testing.
Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus
Authors: Amani Mohammad , Lauterborn Julie C. , Le Aliza A. , Cox Brittney M. , Wang Weisheng , Quintanilla Julian , Cox Conor D. , Gall Christine M. , Lynch Gary 
Published: January 2021

Why layers II/III of entorhinal cortex (EC) deteriorate in advance of other regions during the earliest stages of Alzheimer's disease is poorly understood. Failure of retrograde trophic support from synapses to cell bodies is a common cause of neuronal atrophy, and we accordingly tested for early-life deterioration in projections of rodent layer II EC neurons. Using electrophysiology and quantitative imaging, changes in EC terminals during young adulthood were evaluated in male rats and mice. Field excitatory postsynaptic potentials, input/output curves, and frequency following capacity by lateral perforant path (LPP) projections from lateral EC to dentate gyrus were unchanged from 3 to 8–10 months of age. In contrast, the unusual presynaptic form of long-term potentiation (LTP) expressed by the LPP was profoundly impaired by 8 months in rats and mice. This impairment was accompanied by a reduction in the spine to terminal endocannabinoid signaling needed for LPP-LTP induction and was offset by an agent that enhances signaling. There was a pronounced age-related increase in synaptophysin within LPP terminals, an effect suggestive of incipient pathology. Relatedly, presynaptic levels of TrkB—receptors mediating retrograde trophic signaling—were reduced in the LPP terminal field. LTP and TrkB content were also reduced in the medial perforant path of 8- to 10-month-old rats. As predicted, performance on an LPP-dependent episodic memory task declined by late adulthood. We propose that memory-related synaptic plasticity in EC projections is unusually sensitive to aging, which predisposes EC neurons to pathogenesis later in life.SIGNIFICANCE STATEMENTNeurons within human superficial entorhinal cortex are particularly vulnerable to effects of aging and Alzheimer's disease, although why this is the case is not understood. Here we report that perforant path projections from layer II entorhinal cortex to the dentate gyrus exhibit rapid aging in rodents, including reduced synaptic plasticity and abnormal protein content by 8–10 months of age. Moreover, there was a substantial decline in the performance of an episodic memory task that depends on entorhinal cortical projections at the same ages. Overall, the results suggest that the loss of plasticity and related trophic signaling predispose the entorhinal neurons to functional decline in relatively young adulthood.
Gemfibrozil Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease via PPARα-Dependent Astrocytic GDNF Pathway
Authors: Gottschalk Carl G. , Jana Malabendu , Roy Avik , Patel Dhruv R. , Pahan Kalipada 
Published: January 2021

Parkinson's disease (PD) is the most common neurodegenerative movement disorder in humans. Despite intense investigations, effective therapies are not yet available to halt the progression of PD. Gemfibrozil, a Food and Drug Administration-approved lipid-lowering drug, is known to decrease the risk of coronary heart disease by increasing the level of high-density lipoprotein cholesterol and decreasing the level of low-density lipoprotein cholesterol. This study underlines the importance of gemfibrozil in protecting dopaminergic neurons in an animal model of PD. Oral administration of the human equivalent dose of gemfibrozil protected tyrosine hydroxylase (TH)-positive dopaminergic neurons in the substantia nigra pars compacta and TH fibers in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-insulted mice of both sexes. Accordingly, gemfibrozil also normalized striatal neurotransmitters and improved locomotor activities in MPTP-intoxicated mice. Gemfibrozil-mediated protection of the nigrostriatal and locomotor activities in WT but not PPARα−/−mice from MPTP intoxication suggests that gemfibrozil needs the involvement of peroxisome proliferator-activated receptor α (PPARα) in protecting dopaminergic neurons. While investigating further mechanisms, we found that gemfibrozil stimulated the transcription of glial-derived neurotrophic factor (GDNF) gene in astrocytes via PPARα and that gemfibrozil protected nigral neurons, normalized striatal fibers and neurotransmitters, and improved locomotor activities in MPTP-intoxicated Gfafcremice, but notGdnfΔastromice lacking GDNF in astrocytes. These findings highlight the importance of the PPARα-dependent astroglial GDNF pathway in gemfibrozil-mediated protection of dopaminergic neurons in an animal model of PD and suggest the possible therapeutic use of gemfibrozil in PD patients.SIGNIFICANCE STATEMENTIncreasing the level of glial cell-derived neurotrophic factor (GDNF) in the brain is important for the protection of dopamine neurons in Parkinson's disease (PD). Although gene manipulation and GDNF protein infusion into the brain are available options, it seems from the therapeutic angle that the best option would be to stimulate/induce the production of GDNFin vivoin the brain of PD patients. Here, we delineate that gemfibrozil, a lipid-lowering drug, stimulates GDNF in astrocytes via peroxisome proliferator-activated receptor α (PPARα). Moreover, gemfibrozil protected nigral neurons, normalized striatal fibers and neurotransmitters, and improved locomotor activities from MPTP toxicity via the PPARα-dependent astroglial GDNF pathway. These studies highlight a new property of gemfibrozil and suggest its possible therapeutic use in PD patients.
Musicoterapia Hospitalaria: Impacto del rock and roll en la unidad pediátrica de trasplantes del Hospital Universitario La Paz
Authors: Gallardo Jaime , Gamella González David 
Published: January 2021

En esta investigación analizamos las respuestas de los pacientes pediátricos ante la clásica forma musical del rock and roll. Es un estudio de tres meses con 20 pacientes de la Unidad de Trasplantes del HULP. El trabajo se desarrolló con dos grupos. Uno recibiendo únicamente musicoterapia pasiva y otro, donde además se incluye la participación activa usando una maraca. Los resultados se han obtenido en una única sesión individual con cada paciente. Los instrumentos principales han sido la guitarra, la voz y una maraca. Los resultados muestran que el R&R produce una activación corporal y un aumento de la concentración que se incrementa con la participación activa de una maraca. La interacción del paciente con maraca (participación activa) produce un aumento de las mejoras físicas y neurológicas con respecto a la escucha pasiva en la mayoría de las mediciones. Palabras clave: Musicoterapia, trasplantes, rock and roll, maraca, mejoras físicas y neurológicas.
Pertanggung Jawaban Hukum Anak Terhadap Tindak Pidana (Studi Komparasi Putusan Pengadilan Negeri)
Authors: Hasibuan Muhammad Rizky , Maskufa Maskufa , Nasution Hotnidah 
Published: January 2021

Ada dua tujuan yang diharapkan dari penelitian ini yaitu: 1. Untuk mengetahui penerapan hukum di pengadilan terhadap anak yang melakukan tindak pidana. 2. Untuk mengetahui penyebab terjadinya disparitas putusan pengadilan dalam memutuskan kasus tindak pidana anak. Penelitian ini menggunakan jenis penelitian Normatif dan Empiris dengan pendekatan sosiologi hukum dan menggunakan studi komparasi putusan pengadilan Negeri. Sumber data yang digunakan yaitu putusan pengadilan negeri, Putusan Nomor: 41/Pid.Sus-Anak/2019/PN. Padang, Putusan Nomor: 1/Pid.Sus-Anak/2020/PN Tarutung, Putusan Nomor: 1/Pid.Sus-Anak/2019/ PN Masohi. Metode pengumpulan data dalam penelitian ini adalah melalui peraturan Perundang-undangan, buku-buku, artikel, laporan penelitian, dan jurnal hukum yang berkaitan dengan judul skripsi ini. Teknik pengolahan dan analisis bahan hukum yang digunkan ialah analisis data komparatif yakni membandingkan tiga putusan pengadilan tentang pertanggungjawaban anak terhadap tindak pidana yang dilakukan.Hasil penelitian yang diperoleh dalam tulisan ini yaitu: 1. Penerapan Hukum di Pengadilan terhadap anak yang melakukan tindak pidana terdiri dari pidana pokok dan pidana tambahan. 2. Terjadinya Disparitas Putusan pengadilan selain karena adanya ketentuan dalam Undang-Undang Kekuasaan Kehakiman yang memberi kebebasan bagi hakim dalam menjatuhkan sanksi pidana terhadap pelaku yang telah ditentukan oleh Undang-Undang, juga dilatarbelakangi oleh pertimbangan hakim terhadap fakta-fakta yang ditemukan dalam persidangan.Kata Kunci : Tanggung Jawab Hukum, Anak, Tindak Pidana
Selection of potato genotypes Solanum tuberosum group Andigena by their tolerance to Phytophthora infestans (Mont.) of Bary
Authors: Lagos Regalado Juan José , Lagos Burbano Tulio Cesar , Duarte Alvarado David Esteban , Lagos Santander Liz Katherine 
Published: January 2021

Phytophthora infestans is the most limiting biotic problem of potato crop in Colombia and the world. It is a pathogen that threatens the sustainability of the crop. Therefore, it is necessary to evaluate work collections of potato to identify enotypes that show disease tolerance. The objective of this work was to select genotypes of Solanum tuberosum group Andigena by their tolerance to P. infestans. This study was carried out under conditions of Pasto, in the South of Colombia at 2,820 masl. A total of 76 introductions of guata potatoes were evaluated under natural inoculum, including Capiro as a susceptible control, Betina as moderately tolerant and Pastusa Suprema as highly tolerant. The number of stems and stolons per plant was registered. Disease severity assessments and traits related to the area under the disease progress curve were made. At harvest stage, yield values per plant and its components were recorded. Principal Component and Classification analyses discriminated tolerant introductions of susceptible. Significant positive correlations were found between the yield with the number of stolons, tubers per plant and tuber weight, and negative correlations with everity and area under the relative disease progress curve. The selected introductions showed high yield per plant and mostly minor severities to the population, indicating an agronomic potential that must be evaluated in different environments to determine its adaptability and stability. UdenarStGua53, UdenarStGua61, UdenarStGua68, UdenarStGua73, UdenarStGua75, UdenarStGua77 y UdenarStGua78, coming from the International Potato Center (CIP) are confirmed as a source of tolerance to P. infestans and can be considered as parental within species improvement programs.
Extraction of anthocyanins from Mortiño (Vaccinium floribundum) and determination of their antioxidant capacity
Authors: Pérez Byron Patricio , Endara Andrea Belén , Garrido Javier Alberto , Ramírez Cárdenas Lucía de los Ángeles 
Published: January 2021

Mortiño (Vaccinium floribundum) is a wild Andean berry, with a high content of bioactive compounds, especially anthocyanins, with protective effects against various diseases due to their antioxidant capacity. The aim of this study was to determine the best anthocyanin extraction conditions without affecting the mortiño antioxidant capacity. A completely randomized design with factorial arrangement 23 was applied in the extraction (solvent: ethanol and methanol; concentration: 20 and 60%; temperature: 30 and 60 °C). The anthocyanin content showed that the best extraction conditions were 20 and 60% hydroethanolic solution at 60 °C (P<0.05). For the antioxidant capacity, the treatments were analyzed in a factorial arrangement 22: ethanol and methanol 20%; 30 and 60 °C. The highest antioxidant capacity was found at 20% ethanol and 60 °C (19,653.3±256.62 µmol TE 100 g-1 FW (fresh weight)) by the FRAP method (Ferric Reducing Antioxidant Power) (P<0.05), and with the ABTS methodology, methanol and ethanol (20%), at 60 °C (8458.3±127.45 and 8,258.0±325.05 µmol TE 100 g-1 FW, respectively) (P<0.05). Extraction at 60 °C did not affect the antioxidant properties of anthocyanins. A high correlation was found between both methodologies by Pearson’s Correlation (PC=0.898). In addition, the antioxidant capacity measured by the two methods was highly related to the anthocyanin content of the extracts (PC=0.973 and 0.952, respectively). Other berry species have been extensively investigated for their antioxidant compounds, but there is limited information about the optimization of anthocyanin extraction from mortiño and its high antioxidant capacity important for future industrial applications. As a result, ethanol at 20 and 60%, 60 °C for h are the best conditions to extract and quantify the anthocyanins of the mortiño fruit.
Relationships between agronomic and environmental phosphorus analyses of selected soils
Authors: MM Nthejane  , CC du Preez  , CW van Huyssteen  
Published: January 2021

Phosphorus (P) is an essential nutrient in crop production and is therefore typically applied as phosphatic fertilisers. This can induce soil P concentrations that may contribute to freshwater eutrophication. Soil P tests developed from a water pollution protection perspective are unlike those developed for agronomic purposes and are also not easily adapted to routine analyses. The aim with this study was therefore to establish whether the values of P extracted from a range of soils by various agronomic and environmental P determination methods are related or not. Topsoil samples were collected from virgin soils in central South Africa and treated with KH2PO4 to induce different P concentrations and then incubated for 3 months, while subjected to various wetting and drying cycles. The samples were then analysed for P using the extractants of Bray 1, citric acid, ISFEI, Olsen, and Truog, commonly employed to establish the agronomic P status of soils. Environmental P status was determined with calcium chloride (CaCl2) and ammonium oxalate (DPSox) extractants. Generally good relationships were found between CaCl2 and ISFEI (R2 = 0.72), between DPSox and Truog (R2 = 0.79), and between DPSox and citric acid (R2 = 0.82). Agronomic P soil tests therefore have the potential to be used in regulating application of phosphatic fertilisers to ensure optimum crop yields, while simultaneously limiting freshwater pollution. Further field studies are, however, recommended to determine threshold values from an environmental point of view.