bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental Physical Illnesses and Their Association with Subsequent Externalizing and Internalizing Symptoms in Children
Authors: Kinnunen Lotta , Nordström Tanja , Niemelä Mika , Räsänen Sami , Whittle Sarah , Miettunen Jouko 
Published: August 2021

AbstractParental physical illnesses can be stressful for children. We estimated the prevalence of children who experience parental physical illnesses, and whether parental physical illnesses during childhood were associated with behavioral problems in adolescence. Data on children from the Northern Finland Birth Cohort 1986 was collected through questionnaires at ages 8 and 16 (n = 7037). Data on parental illness diagnosed during this study period was obtained from health registers. We investigated the association between parental physical illness (based on the International Classification of Diseases) and children’s behavioral problems at age 16 (measured by the Youth Self-Report questionnaire). During the study period, 3887 (55.2%) children had a parent with at least one physical illness. Associations were found between parental physical illness and children’s behavioral problems, with most associations found between maternal illness and males’ externalizing problems, and females’ internalizing problems. After adjusting for child behavioral problems at age 8, parental psychiatric illness and socioeconomic status, and multiple testing correction, only associations between parental physical illness and male behavioral problems were significant. Interestingly, parental illness was associated with lower problems. A notable proportion of children experience parental physical illnesses. Although mixed, our findings suggest that the impact of parental physical illness on children’s behavioral problems is complex, and that the experience of parental illness may lead to resilience in males. This study emphasizes that children’s needs should be taken into account when treating a parent with physical illness.
Navigating Family Involvement in Domestic Violence Fatality Review: Conceptualising Prospects for Systems and Relational Repair
Authors: Rowlands James , Cook Elizabeth A. 
Published: August 2021

Abstract
Purpose
Family involvement is a key element of Domestic Homicide Review (DHR), the form of Domestic Violence Fatality Review (DVFR) found in England and Wales. Family involvement is framed as having dual purposes: first, as a benefit to DHRs, enabling a fuller picture of victims’ experiences; second, as a benefit to families themselves, notably as a therapeutic or cathartic opportunity. However, these dual purposes have been little considered. This conceptual article responds to this absence by interrogating the purpose, process and outcomes of family involvement within DHRs.

Method
To explicate purpose, process and outcomes, we synthesise policy, practice and the extant empirical and theoretical literature relating to family involvement in DHRs. We supplement this by engaging with a broader body of emerging research on family involvement in other review systems, analysing this through a lens of citizenship and participation.

Results
Family involvement in DHRs is little explicated and there is a need to better engage with how family are involved in DHRs, as a way of increasing transparency for family rights. By way of response, a tentative conceptual framework is proposed which situates family involvement as demonstrative of systems- and relational-repair.

Conclusions
The article concludes by arguing for greater attention to the Theory(s) of Change underpinning both the place of the family and their testimony, as well as the DHR system as a whole. Such clarity would benefit family, both as the subject of professional interactions but, critically, as agents in the DHR process in their own right.
Immigration Policy Vulnerability Linked to Adverse Mental Health Among Latino Day Laborers
Authors: Haro-Ramos Alein Y. , Rodriguez Hector P. 
Published: August 2021

AbstractLatino day laborers in the United States are socially and economically vulnerable due to exclusionary immigration policies. Using data from a multi-mode survey, we examine the relationship between immigration policy legal vulnerability and mental health outcomes among 138 Latino, male day laborers (mean age = 45.65, SD = 12.05). Multivariable linear and logistic regression models separately estimated the effect of legal vulnerability, as measured by the Perceived Immigration Policy Effects Scale, on anxiety and depression symptoms and a positive depression and anxiety screening, respectively. Approximately 26.1% and 27.9% of day laborers reported depression and anxiety symptoms, respectively. In each adjusted model, we find a positive relationship between legal vulnerability and adverse mental health. Immigration policy legal vulnerability is associated with more depression and anxiety symptoms among Latino day laborers. Policies to reduce legal vulnerability, such as pathways to citizenship and employment authorization, may support Latino day laborers' mental health outcomes.
Cancer Survivorship: Religion in Meaning Making and Coping Among a Group of Black Prostate Cancer Patients in South Africa
Authors: Nkoana Shai , Sodi Tholene , Makgahlela Mpsanyana , Mokwena Jabu 
Published: September 2021

AbstractThe purpose of the study was to explore the role of religion in meaning making and coping among a group of black patients receiving some form of prostate cancer treatment at a public hospital in Limpopo Province, South Africa. A sample of 20 prostate cancer survivors, with ages ranging from 67 to 85 years (meanage = 76yrs; SD = 5.3) selected through purposive sampling. Data were collected through in-depth, semi-structured individual interviews and analysed using interpretative phenomenological analysis (IPA). The findings demonstrated that religion is an important factor in meaning making and coping by prostate cancer survivors. The findings suggest that healthcare practitioners need to pay close attention to the meanings that cancer patients assign to their illness to provide the appropriate care and support.
Changes in the expression level of genes encoding transcription factors and cell wall-related proteins during Meloidogyne arenaria infection of maize (Zea mays)
Authors: Przybylska Arnika , Spychalski Maciej 
Published: September 2021

Abstract
Background
Meloidogyne arenaria is an economically important root-knot nematode (RKN) species whose hosts include maize (Zea mays). The plant response to RKN infection activates many cellular mechanisms, among others, changes in the expression level of genes encoding transcription and elongation factors as well as proteins related to cell wall organization.

Methods and results
This study is aimed at characterization of expression of selected transcription and elongation factors encoding the genes WRKY53, EF1a, and EF1b as well as the ones encoding two proteins associated with cell wall functioning (glycine-rich RNA-binding protein, GRP and polygalacturonase, PG) during the maize response to M. arenaria infection. The changes in the relative level of expression of genes encoding these proteins were assessed using the reverse transcription-quantitative real-time PCR. The material studied were leaves and root samples collected from four maize varieties showing different susceptibilities toward M. arenaria infection, harvested at three different time points. Significant changes in the expression level of GRP between susceptible and tolerant varieties were observed.

Conclusions
Results obtained in the study suggest pronounced involvement of glycine-rich RNA-binding protein and EF1b in the maize response and resistance to RKN.
Household Chaos and Child Behavior Problems Predict Maternal Well-being
Authors: Yalcintas Sumeyra , Pike Alison , Oliver Bonamy R. 
Published: September 2021

AbstractThe aim of the study was to investigate predictors of maternal well-being in mothers of twins. As well as being important in its own right, maternal well-being is a crucial predictor of parenting (Belsky in Child Dev. 55(1):83, 1984). Based on previous research (Pike et al. in Int J Beh Dev. 30(1):55–66, 2006) we expected that household chaos (Confusion, Hubbub, and Order) and child behavior problems would predict maternal depression, stress and anxiety. The data for the study was taken from the Twins, Family and Behavior Study (TFaB) -- a longitudinal UK study of twins born in 2009 and 2010. One hundred and fifty-eight mothers of twins (Mchild age= 6.01 years, SDage = 0.50) reported on household chaos, child disruptive behaviors and their own well-being. Higher levels of household chaos were linked to maternal depressive, anxiety and stress related symptoms. More child behavior problems were related to more depressive and stress symptoms but not anxiety. The findings show promise for future research investigating different types of maternal well-being and suggested practical implications, such as intervening on concrete aspects of household chaos to improve maternal well-being.
Allocation of time and child socio-emotional skills
Authors: Meroni Elena Claudia , Piazzalunga Daniela , Pronzato Chiara 
Published: September 2021

AbstractIn this study, we investigate the effect of time allocation on children’s non-cognitive development, using data from the Millennium Cohort Study (UK) and focusing on children aged 7 and 11 years. We classify the time spent outside of school into seven groups of activities and evaluate their impact on five socio-emotional skills drawn from the Strength and Difficulties Questionnaire, leveraging the data’s panel structure. We subsequently test the robustness of our estimates against endogeneity issues. Time spent on sports, studying, reading, tidying up and active time with parents have beneficial effects, while video-screen time and extra hours at school have harmful effects.
Supply Chain Innovations and Partial Ownership
Authors: Hunold Matthias , Shekhar Shiva 
Published: August 2021

AbstractWhen knowledge sharing is non-contractible, we show that competing downstream firms may prefer to help improve an inefficient alternative supply source than help to improve the technology of the efficient actual supplier—even if this is costless. A downstream firm can have incentives to decrease the efficiency of the actual supplier in order to improve its outside options. Non-controlling partial backward ownership can—through the participation of the downstream firm(s) in the upstream profits—align the incentives of the supplier and its competing customers. This improves industry performance while simultaneously benefiting consumers. Partial backward ownership has similar effects as strengthening a downstream firm’s bargaining power and making knowledge sharing contractible.
Validation of an Emission Model for a Marine Diesel Engine with Data from Sea Operations
Authors: Mocerino Luigia , Soares C. Guedes , Rizzuto Enrico , Balsamo Flavio , Quaranta Franco 
Published: September 2021

AbstractIn this study, a model is developed to simulate the dynamics of an internal combustion engine, and it is calibrated and validated against reliable experimental data, making it a tool that can effectively be adopted to conduct emission predictions. In this work, the Ricardo WAVE software is applied to the simulation of a particular marine diesel engine, a four-stroke engine used in the maritime field. Results from the bench tests are used for the calibration of the model. Finally, the calibration of the model and its validation with full-scale data measured at sea are presented. The prediction includes not only the classic engine operating parameters for a comparison with surveys but also an estimate of nitrogen oxide emissions, which are compared with similar results obtained with emission factors. The calibration of the model made it possible to obtain an overlap between the simulation results and real data with an average error of approximately 7% on power, torque, and consumption. The model provides encouraging results, suggesting further applications, such as in the study on transient conditions, coupling of the engine model with the ship model for a complete simulation of the operating conditions, and optimization studies on consumption and emissions. The availability of the emission data during the sea trial and validated simulation results are the strengths and novelties of this work.
Advances in Research on Bladder Cancer Targeting Peptides: a Review
Authors: Zheng Bin , Zhang Pu , Wang Heng , Wang Jinxue , Liu Zheng Hong , Zhang DaHong 
Published: September 2021

AbstractBladder cancer (Bca) is the second most common malignant tumor of the genitourinary system in Chinese male population with high potential of recurrence and progression. The overall prognosis has not been improved significantly for the past 30 years due to the lack of early theranostic technique. Currently the early theranostic technique for bladder cancer is mainly through the intravesical approach, but the clinical outcomes are poor due to the limited tumor-targeting efficiency. Therefore, the targeting peptides for bladder cancer provide possibility to advance intravesical theranostic technique. However, no systematic review has covered the wide use of the targeting peptides for intravesical theranostic techniques in bladder cancer. Herein, a summary of original researches introduces all aspects of the targeting peptides for bladder cancer, including the peptide screening, the targeting mechanism and its preclinical application.
Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice
Authors: Longatti Anna , Ponzoni Luisa , Moretto Edoardo , Giansante Giorgia , Lattuada Norma , Colombo Maria Nicol , Francolini Maura , Sala Mariaelvina , Murru Luca , Passafaro Maria 
Published: August 2021

AbstractRho GTPases are a class of G-proteins involved in several aspects of cellular biology, including the regulation of actin cytoskeleton. The most studied members of this family are RHOA and RAC1 that act in concert to regulate actin dynamics. Recently, Rho GTPases gained much attention as synaptic regulators in the mammalian central nervous system (CNS). In this context, ARHGAP22 protein has been previously shown to specifically inhibit RAC1 activity thus standing as critical cytoskeleton regulator in cancer cell models; however, whether this function is maintained in neurons in the CNS is unknown. Here, we generated a knockout animal model for arhgap22 and provided evidence of its role in the hippocampus. Specifically, we found that ARHGAP22 absence leads to RAC1 hyperactivity and to an increase in dendritic spine density with defects in synaptic structure, molecular composition, and plasticity. Furthermore, arhgap22 silencing causes impairment in cognition and a reduction in anxiety-like behavior in mice. We also found that inhibiting RAC1 restored synaptic plasticity in ARHGAP22 KO mice. All together, these results shed light on the specific role of ARHGAP22 in hippocampal excitatory synapse formation and function as well as in learning and memory behaviors.
Government subsidies and online branding for agricultural products
Authors: Zhang Zongming , Zhao Hua , Zeng Xinyu 
Published: August 2021

AbstractOnline branding plays an increasingly vital role for agricultural products in agriculture and e-commerce industries alike. To improve the cooperation between farmers and e-retailers, and to increase awareness of agricultural products through online branding, many governments implement series of subsidy policies. We investigate the impact of government subsidies by proposing a three-player game model (consisting of a government, a farmer, and an e-retailer) in supply chains. More specifically, we develop four Stackelberg game scenarios, including a benchmark scenario in which government provides no subsidies, two scenarios in which government subsidizes either farmer or e-retailer without subsidizing the other, and one in which both are subsidized. We find awareness of online branding for agricultural products is positively related to farmers? market sensitivity while e-retailers? cost factor shows a negative relation; optimal awareness emerges when both farmers and retailers are subsidized. In turn, farmers and retailers achieve their best profits when both are subsidized. Furthermore, farmers? profits are higher than e-retailers? in every subsidy scenario. We obtain the most effective parameters for government subsidies using ex ante and ex post strategies, extending our model by incorporating spillover effects. Most of our conclusions are consistent with intuition and propositions we began with, but it is interesting to note that farmers? best profits appear when farmers receive subsidies and e-retailers do not.
Immunohistochemical and qPCR Detection of SARS-CoV-2 in the Human Middle Ear Versus the Nasal Cavity: Case Series
Authors: Kurabi Arwa , Pak Kwang , DeConde Adam S. , Ryan Allen F. , Yan Carol H. 
Published: August 2021

AbstractViral infections have already been implicated with otitis media and sudden sensorineural hearing loss. However, the pathophysiology of COVID-19 as it relates to otologic disorders is not well-defined. With the spread of SARS-CoV-2, it is important to evaluate its colonization of middle ear mucosa. Middle ear and nasal tissue samples for quantitative RT-PCR and histologic evaluations were obtained from post-mortem COVID-19 patients and non-diseased control patients. Here we present evidence that SARS-CoV-2 colonizes the middle ear epithelium and co-localizes with the primary viral receptor, angiotensin-converting enzyme 2 (ACE2). Both middle ear and nasal epithelial cells show relatively high expression of ACE2, required for SARS-CoV-2 entry. The epithelial cell adhesion molecule (EpCAM) was use as a biomarker of epithelia. Furthermore, we found that the viral load in the middle ear is lower than that present in the nasal cavity.
Workflow to build a continuous static elastic moduli profile from the drilling data using artificial intelligence techniques
Authors: Siddig Osama , Elkatatny Salaheldin 
Published: August 2021

AbstractRock mechanical properties play a crucial role in fracturing design, wellbore stability and in situ stresses estimation. Conventionally, there are two ways to estimate Young’s modulus, either by conducting compressional tests on core plug samples or by calculating it from well log parameters. The first method is costly, time-consuming and does not provide a continuous profile. In contrast, the second method provides a continuous profile, however, it requires the availability of acoustic velocities and usually gives estimations that differ from the experimental ones. In this paper, a different approach is proposed based on the drilling operational data such as weight on bit and penetration rate. To investigate this approach, two machine learning techniques were used, artificial neural network (ANN) and support vector machine (SVM). A total of 2288 data points were employed to develop the model, while another 1667 hidden data points were used later to validate the built models. These data cover different types of formations carbonate, sandstone and shale. The two methods used yielded a good match between the measured and predicted Young’s modulus with correlation coefficients above 0.90, and average absolute percentage errors were less than 15%. For instance, the correlation coefficients for ANN ranged between 0.92 and 0.97 for the training and testing data, respectively. A new empirical correlation was developed based on the optimized ANN model that can be used with different datasets. According to these results, the estimation of elastic moduli from drilling parameters is promising and this approach could be investigated for other rock mechanical parameters.
Dynamic Analysis and Simulation of an Optically Levitated Rotating Ellipsoid Rotor in Liquid Medium
Authors: Zhu Qi , Li Nan , Su Heming , Li Wenqiang , Hu Huizhu 
Published: September 2021

AbstractOptical trap, a circularly polarized laser beam can levitate and control the rotation of microspheres in liquid medium with high stiffness. Trapping force performs as confinement while the trapped particle can be analog to a liquid floated gyroscope with three degree-of-freedom. In this work, we analyzed the feasibility of applying optically levitated rotor in the system. We presented the dynamic analysis and simulation of an ellipsoid micron particle. The precession motion and nutation motion of a rotating ellipsoid probe particle in optical tweezers were performed. We also analyzed the attitude changes of an optically levitated ellipsoid when there was variation of the external torque caused by deviation of the incident light that was provided. Furthermore, the trail path of the rotational axis vertex and the stabilization process of a particle of different ellipticities were simulated. We compared the movement tendencies of particles of different shapes and analyzed the selection criteria of ellipsoid rotor. These analytical formulae and simulation results are applicable to the analysis of the rotational motion of particles in optical tweezers, especially to the future research of the gyroscope effect.
Best clinical practice guidance for conscious sedation of children undergoing dental treatment: an EAPD policy document
Authors: Ashley P. , Anand P. , Andersson K. 
Published: August 2021

AbstractBackgroundDue to fear and/or behaviour management problems, some children are unable to cooperate for dental treatment using local anaesthesia and psychological support alone. Sedation is required for these patients in order for dentists to be able to deliver high quality, pain-free dental care.The aim of this guideline is to evaluate the efficacy and relative efficacy of conscious sedation agents and dosages for behaviour management in paediatric dentistry and to provide guidance as to which sedative agents should be used.MethodsThese guidelines were developed using a multi-step approach adapted from that outlined by the National Institute for Clinical Excellence (NICE (2020) Developing NICE Guidelines: the manual.https://www.nice.org.uk/process/pmg20/chapter/introduction#main-stages-of-guideline-development. Accessed 7 Oct 2020). Evidence for this guideline was provided from a pre-existing Cochrane review (Ashley et al. Cochrane Database Syst Rev 12:CD003877, 2018) supplemented by an updated search and data extraction up to May 2020.ResultsStudies were from 18 different countries and had recruited 4131 participants overall with an average of 70 participants per study. Ages ranged from 0 to 16 years with an average age of 5.6 years across all included studies. A wide variety of drugs or combinations of drugs (n = 38) were used and delivered orally, intranasally, intravenously, rectally, intramuscularly, submucosally, transmucosally or by inhalation sedation. Twenty-four different outcome measures for behaviour were used. The wide range of drug combinations and outcome measures used greatly complicated description and analysis of the data.ConclusionOral midazolam is recommended for conscious dental sedation. Midazolam delivered via other methods or nitrous oxide/oxygen sedation could be considered, but the evidence for both was very low.