bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for Bleeding After Endoscopic Submucosal Dissection for Gastric Cancer in Elderly Patients Older Than 80 Years in Japan
Authors: Sugimoto Mitsushige , Hatta Waku , Tsuji Yosuke , Yoshio Toshiyuki , Yabuuchi Yohei , Hoteya Shu , Doyama Hisashi , Nagami Yasuaki , Hikichi Takuto , Kobayashi Masakuni , Morita Yoshinori , Sumiyoshi Tetsuya , Iguchi Mikitaka , Tomida Hideomi , Inoue Takuya , Mikami Tatsuya , Hasatani Kenkei , Nishikawa Jun , Matsumura Tomoaki , Nebiki Hiroko , Nakamatsu Dai , Ohnita Ken , Suzuki Haruhisa , Ueyama Hiroya , Hayashi Yoshito , Murata Masaki , Yamaguchi Shinjiro , Michida Tomoki , Yada Tomoyuki , Asahina Yoshiro , Narasaka Toshiaki , Kuribayashi Shiko , Kiyotoki Shu , Mabe Katsuhiro , Fujishiro Mitsuhiro , Masamune Atsushi , Kawai Takashi 
Published: October 2021

INTRODUCTION:
As the aging of people in a society advances, the number of elderly patients older than 80 years in Japan with gastric cancer continues to increase. Although delayed ulcer bleeding is a major adverse event after endoscopic submucosal dissection (ESD), little is known about characteristic risk factors for bleeding in elderly patients undergoing ESD. This study aimed to evaluate risk factors for delayed bleeding after ESD for gastric cancer in elderly patients older than 80 years.

METHODS:
We retrospectively evaluated the incidence of delayed bleeding after ESD in 10,320 patients with early-stage gastric cancer resected by ESD between November 2013 and January 2016 at 33 Japanese institutions and investigated risk factors for delayed bleeding in elderly patients older than 80 years.

RESULTS:
The incidence of delayed bleeding in elderly patients older than 80 years was 5.7% (95% confidence interval [CI]: 4.6%–6.9%, 95/1,675), which was significantly higher than that in nonelderly (older than 20 years and younger than 80 years) patients (4.5%, 4.1%–5.0%, 393/8,645). Predictive factors for ESD-associated bleeding differed between nonelderly and elderly patients. On multivariate analysis of predictive factors at the time of treatment, risk factors in elderly patients were hemodialysis (odds ratio: 4.591, 95% CI: 2.056–10.248, P < 0.001) and warfarin use (odds ratio: 4.783, 95% CI: 1.689–13.540, P = 0.003).

DISCUSSION:
This multicenter study found that the incidence of delayed bleeding after ESD in Japanese patients older than 80 years was high, especially in patients receiving hemodialysis and taking warfarin. Management of ESD to prevent delayed bleeding requires particular care in patients older than 80 years.
Hölderlins Homburger Folioheft in diachroner Darstellung
Authors: Steimer Hans Gerhard 
Published: October 2021

Abstract
Literary compositional drafts and working manuscripts preserve traces of the gradual process of writing and its different stages. In the static medium of print, genetic editions are confronted with the problem of depicting the dynamic evolution of texts. Presenting the variants in line-by-line synoptic display disregards the spatial arrangement on the manuscript pages. On the other hand, giving a topographic representation of the writing in diplomatic transcripts might stratify it into a few chronological layers but is unable to sufficiently reproduce the dynamic process to an elaborate degree. Consequently, the screen is better suited to visualise the writing process. The digital presentation of the ‘Homburg Folio’, the most important manuscript of Friedrich Hölderlin’s late work, offers not only the transcriptional record as known from print media but displays the process of writing and revision on each of the facsimile’s pages itself (https://homburgfolio.wlb-stuttgart.de). Thus, it is possible to visualise writing both as an act in time and its graphic result on the space of a page. It confines itself to the presentation of the genesis without any constitution of a text. The combination of these different operations has often led to errors. Decoupling the genetic analysis from the extrapolation of text reveals its potential.
Economic aspect of combined transport
Authors: Říha Zdeněk , Dočkalíková Iveta 
Published: October 2021

Abstract
The article deals with the current issues of combined transport; at the beginning, the crucial terms and definitions are stated. Combined transport is evaluated on the basis of statistics in the Czech Republic. According to these statistics, combined transport has a rising tendency, although the potential has not been fully utilized. The article defines reasons why carriers might choose only road transport. Problems of the utilization of combined transport from the carriers´ point of view are mentioned; increased demand for organization and carriage in particular. Furthermore, it focuses on modern trends in combined transport, especially in terms of modern technologies and the utilization of informatics systems. In the conclusion, the article also presents a method of economic evaluation of combined transport on the basis of its cost comparison with road transport.
Inhibitory effect of mitoquinone against the α-synuclein fibrillation and relevant neurotoxicity: possible role in inhibition of Parkinson’s disease
Authors: Yu Gege , Wang Yonghui , Zhao Jinhua 
Published: October 2021

Abstract
Extensive studies have reported that interaction of α-synuclein amyloid species with neurons is a crucial mechanistic characteristic of Parkinson’s disease (PD) and small molecules can downregulate the neurotoxic effects induced by protein aggregation. However, the exact mechanism(s) of these neuroprotective effects by small molecules remain widely unknown. In the present study, α-synuclein samples in the amyloidogenic condition were aged for 120 h with or without different concentrations of mitoquinone (MitoQ) as a quinone derivative compound and the amyloid characteristics and the relevant neurotoxicity were evaluated by Thioflavin T (ThT)/Nile red fluorescence, Congo red absorption, circular dichroism (CD), transmission electron microscopy (TEM), cell viability, lactate dehydrogenase (LDH), reactive oxygen species (ROS), reactive nitrogen species (RNS), malondialdehyde (MDA), superoxide dismutase (SOD), and caspase-9/-3 activity assays. Results clearly showed the capacity of MitoQ on the inhibition of the formation of α-synuclein fibrillation products through modulation of the aggregation pathway by an effect on the kinetic parameters. Also, it was shown that α-synuclein samples aged for 120 h with MitoQ trigger less neurotoxic effects against SH-SY5Y cells than α-synuclein amyloid alone. Indeed, co-incubation of α-synuclein with MitoQ reduced the membrane leakage, oxidative and nitro-oxidative stress, modifications of macromolecules, and apoptosis.
Artificial metalloenzymes in a nutshell: the quartet for efficient catalysis
Authors: Ebensperger Paul , Jessen-Trefzer Claudia 
Published: October 2021

Abstract
Artificial metalloenzymes combine the inherent reactivity of transition metal catalysis with the sophisticated reaction control of natural enzymes. By providing new opportunities in bioorthogonal chemistry and biocatalysis, artificial metalloenzymes have the potential to overcome certain limitations in both drug discovery and green chemistry or related research fields. Ongoing advances in organometallic catalysis, directed evolution, and bioinformatics are enabling the design of increasingly powerful systems that outperform conventional catalysis in a growing number of cases. Therefore, this review article collects challenges and opportunities in designing artificial metalloenzymes described in recent review articles. This will provide an equitable insight for those new to and interested in the field.
Integration of deterministic and game-based energy consumption scheduling for demand side management in isolated microgrids
Authors: ElGhanam Eiman A. , Osman Ahmed H. , Hassan Mohamed S. , Assaf Tasneem , Mir Hasan 
Published: October 2021

Abstract
In this work, a group Autonomous Demand-Side Management (ADSM) program for day-ahead scheduling of energy consumption profiles in an isolated microgrid is proposed, aiming to reduce the overall energy generation cost. The proposed program is applied to a Multiple-Sources Multiple-Customers (MSMC) system, consisting of a shared centralized energy source, distributed Renewable Energy Sources (RESs) and Distributed Storage Elements (DSEs). The proposed program integrates a Deterministic Energy Management (DEM) strategy with a Tabu Search (TS)-based scheduling game to reduce the computational complexity while acknowledging the intermittent nature of RESs as well as the level of customers’ comfort. Moreover, an equitable billing mechanism for charging customers based on their energy consumption and adherence to their assigned schedules is implemented. Simulations of the proposed program reveal that the TS-based algorithm offers similar energy generation costs and peak-to-average energy ratio (PAER) to those obtained with a benchmark Branch and Bound (BB) algorithm, with a significantly lower computational complexity, while being superior in computational complexity, energy costs and PAER to an algorithm based on Parallel Monte Carlo Tree Search (P-MCTS). Furthermore, the proposed integrated DEM and TS-based scheduling strategy in an MSMC system is demonstrated to offer 48% reduction in the one-day energy generation costs, compared to a SSMC system managed using a TS-based scheduling game alone.
The Old and the New Israel: The Cultural Origins of the Special Relationship
Authors: Shalev Eran 
Published: October 2021

Abstract
Understandings of the new American nation as a “Second Israel,” and a prevalent political discourse devoted to the narratives of the Old Testament, were a distinct trait of the early United States. Indeed, the images and narratives of the Old Testament were as common in the formative decades of the United States, in the words of the great historian Perry Miller, as “the air that the people breathed.” This attachment to the Old Testament, and the fact that American nationalism and twentieth century Zionism crystalized around the biblical history of the Israelites, bears considerably on the relationship of the two nations. The “special” bond between the modern countries, which is commonly understood in terms of pragmatism, interests, and shared ideologies, thus rests on a deep cultural connection. The American public’s consistent backing of the State of Israel (one that far surpasses the constituency of evangelical Christian Zionists), which politically translates into a robust, lasting and bi-partisan support that defies the arithmetic of appeals to Jewish voters (or donors) seems puzzling at times. It becomes more intelligible in light of the centuries-long tradition of American public speech describing the nation as a new incarnation of biblical Israel. This usable biblical past, which continues to influence American culture in meaningful ways, adds an important dimension for our understanding of the “special relationship” between the United States and Israel.
Use and perception of complementary and alternative medicine among Iranian psychologists
Authors: Tehrani Hadi , Nejatian Mahbobeh , Jafari Alireza 
Published: October 2021

Abstract

Objectives
The seeking and use of Complementary and Alternative Medicine (CAM) modalities by people to treat mental disorders has increased and it is necessary for psychologists to have the necessary information in this field. This study aims to evaluate the use and perception of CAM by Iranian psychologists.

Methods
This cross-sectional study was conducted on 100 psychologists selected by the census in 2019. Data collection tools consisted of four sections of the demographic section, the CAM questionnaire for psychologists, awareness of CAM, and use of CAM. The validity and reliability of this questionnaire were confirmed.

Results
The mean (standard deviation) scores of attitude and educational needs were 40.45 (11.36) and 33.93 (5.96), respectively. Only 19.25% of psychologists had sufficient knowledge of CAM, and most of them (56.34%) reported that there is an educational need for CAM. In this study, 64% of psychologists used CAM for themselves. There was a significant relationship between the attitude toward CAM modalities and the suggestion of CAM to the clients (p=0.025). There was also a significant relationship between the use of CAM by psychologists and the suggestion of these modalities to their clients (p<0.001).

Conclusions
Psychologists had not sufficient awareness about CAM and had a moderate attitude. Most of the psychologists reported that there is educational need for CAM. Therefore, it is necessary to design and implement appropriate training courses for psychologists toward CAM modalities.
Mechanical behavior of thin-walled steel under hard contact with rigid seabed rock: Theoretical contact approach and nonlinear FE calculation
Authors: Rio Prabowo Aditya , Tuswan Tuswan , Adiputra Ristiyanto , Do Quang Thang , Sohn Jung Min , Surojo Eko , Imaduddin Fitrian 
Published: October 2021

Abstract
This work aims to investigate the mechanical behavior of steel-plated structures under a raking incident and to quantify the effect of the mesh size in nonlinear finite element (NLFE) analysis. To conveniently comprehend nonlinear phenomena, i.e., the grounding which takes place in this work, a series of theoretical contact formulations was defined. In the main analysis, raking, which is a part of the grounding scenario, was strictly assumed as contact between a tanker, which was assumed to have thin-walled steel, and a seabed rock in the form of a solid obstruction. Designed raking scenarios were calculated using the FE method by using the nonlinear phenomena of the material behavior in the calculation. The findings of this work indicated that the possibility of expanding the recommended mesh size in FE simulation should be evaluated by quantifying the behavior of structural responses, such as energy, the force damage pattern, and acceleration, subjected to a variety of applied meshing techniques. The results concluded that a notable difference occurred when the mesh size was more than 132 mm (ratio 11 based on the plate dimension in this work), and this size is strictly recommended to be used for calculation of the element length-to-thickness (ELT) ratio. Assessment in time simulation showed that applying larger mesh sizes will reduce the simulation time but increase the maximum values of the crashworthiness parameters, i.e., energy, force, acceleration, and displacement.
Update on endothelial dysfunction in COVID-19: severe disease, long COVID-19 and pediatric characteristics
Authors: Gavriilaki Eleni , Eftychidis Ioannis , Papassotiriou Ioannis 
Published: October 2021

Abstract

Objectives
To review current literature on the role of endothelial dysfunction in coronavirus disease-2019 (COVID-19) infection in terms of pathophysiology, laboratory features and markers, clinical phenotype in adults and children, as well as long COVID-19.

Content
We conducted a thorough assessment of the literature and critically analyzed current data, mostly utilizing the PubMed and Medline search engines to find original studies published in the previous decade.

Summary and Outlook
Accumulating evidence suggests that endothelial dysfunction may be a common denominator of severe COVID-19 in adults and children, as well as long COVID-19, implicating mutual pathophysiological pathways. This narrative review summarizes the up-to-date knowledge of endothelial dysfunction caused by COVID-19, including novel aspects of long COVID-19 and pediatric disease. This knowledge is important in order not only to understand the multisystemic attack of COVID-19, but also to improve patient management and prognosis.
Two tractable models of dynamic light scattering and their application to Fano resonances
Authors: Tribelsky Michael I. , Miroshnichenko Andrey E. 
Published: October 2021

Abstract
We introduce two tractable analytical models to describe dynamic effects at resonant light scattering by subwavelength particles. One of them is based on a generalization of the temporal coupled-mode theory, and the other employs the normal mode approach. We show that sharp variations in the envelope of the incident pulse may initiate unusual, counterintuitive dynamics of the scattering associated with interference of modes with fast and slow relaxation. To exhibit the power of the models, we apply them to explain the dynamic light scattering of a square-envelope pulse by an infinite circular cylinder made of GaP, when the pulse carrier frequency lies in the vicinity of the destructive interference at the Fano resonances. We observe and explain intensive sharp spikes in scattering cross-sections just behind the leading and trailing edges of the incident pulse. The latter occurs when the incident pulse is over and is explained by the electromagnetic energy released in the particle at the previous scattering stages. The accuracy of the models is checked against their comparison with results of the direct numerical integration of the complete set of Maxwell’s equations and occurs very high. The models’ advantages and disadvantages are revealed, and the ways to apply them to other types of dynamic resonant scattering are discussed.
The crystal structure of 3-amino-5-carboxypyridin-1-ium bromide, C6H7BrN2O2
Authors: Du Chao-Jun , Niu De-Long , Yan Zhen-Li , Zheng Shi-Li , Zeng Yan 
Published: October 2021

Abstract
C6H7BrN2O2, triclinic,

P

1
‾

$P&#x203e;{1}$

(no. 2), a = 7.3026(4) Å, b = 7.4618(4) Å, c = 7.8746(4) Å, α = 81.542(3)°, β = 89.459(3)°, γ = 61.718(3)°, V = 372.86(4) Å3, Z = 2, R

gt
(F) = 0.0209, wR

ref
(F
2) = 0.0473, T = 150(2) K.
Recovering cointegration via wavelets in the presence of non-linear patterns
Authors: Martínez Compains Jorge , Rodríguez Carreño Ignacio , Gençay Ramazan , Trani Tommaso , Ramos Vilardell Daniel 
Published: October 2021

Abstract
Johansen’s Cointegration Test (JCT) performs remarkably well in finding stable bivariate cointegration relationships. Nonetheless, the JCT is not necessarily designed to detect such relationships in presence of non-linear patterns such as structural breaks or cycles that fall in the low frequency portion of the spectrum. Seasonal adjustment procedures might not detect such non-linear patterns, and thus, we expose the difficulty in identifying cointegrating relations under the traditional use of JCT. Within several Monte Carlo experiments, we show that wavelets can empower more the JCT framework than the traditional seasonal adjustment methodologies, allowing for identification of hidden cointegrating relationships. Moreover, we confirm these results using seasonally adjusted time series as US consumption and income, gross national product (GNP) and money supply M1 and GNP and M2.
PROBLEMAS PROCESALES Y DE EJECUCIÓN PENITENCIARIA: JUSTICIA RESTAURATIVA Y DELITOS SOCIOECONÓMICOS .
Authors: REBOLLO VARGAS Rafael 
Published: October 2021

En el presente trabajo se abordan las dificultades procesales en el ámbito de la justicia restauradora y los delitos socioeconómicos. Se examina la viabilidad de la acusación particular, concluyendo que no es el mecanismo idóneo para poner en marcha el procedimiento ya que, la legitimación procesal se atribuye a quien no es ofendido ni perjudicado, mientras que en estos delitos existen unos bienes jurídicos de índole supraindividual y, con ello, unos perjudicados. Por el contrario, se propone que el mecanismo procesal idóneo para la defensa de esos bienes jurídicos supraindividuales reside en las acciones colectivas (art. 7.3 LOPJ), que deberían recibir el tratamiento de una acción particular colectiva entendida como el ejercicio de la acción penal por personas jurídicas o agrupaciones en defensa de intereses colectivos y difusos. En segundo lugar, se analizan los problemas de ejecución penitenciaria inherentes a la justicia restaurativa en el ámbito de los delitos socioeconómicos.
Effect of micro osteo-perforations (MOP) on the rate of tooth movement and levels of interleukin-1β - a split mouth study
Authors: Bavikati Venkata Naidu , Muhameed Abdul Rasheed , Mohaley Nikitha , Thimmaiah Manjula K. , Botlagunta Keerthi Kavya , Basalingappa Sangamesh 
Published: October 2021

Introduction. Various procedures are available today to enhance tooth movement, with relative success rates, one among them being Micro Osteo Perforation (MOP). Our aim is to assess the rate of tooth movement and interleukin 1β levels in gingival crevicular fluid levels (GCF)after MOPs.
Methodology. A group of 22 patients were selected, who required first premolars extraction and were designated for the split mouth study with equal allocation. MOP was performed on the right side, three vertical MOPs were given using 1.2 X 8 mm mini implants with the gap of 2 mm between them and surgical depth of the implant insertion was 5 mm. The left side was used as control. The individual canine retraction was initiated with placement of 150 grams on 19*25 SS wire. The case was evaluated at different timelines for canine retraction and Interleukin 1β levels.
Results. There was a significant difference in the rate of canine movement at 45 days (1.42 mm) and end of canine retraction on experimental side(2.61 mm). The GCF levels were raised at T1 and T2 intervals on the side of MOP and were statically significant (p=0.00).
Conclusion. MOP is a minimally invasive procedure which accelerates the tooth movement by 20%. The increase in IL 1βlevels indicates a higher rate of chemical interaction on the surgically assisted side. For enhanced efficiency MOPs should be repeated every 6-8 weeks.
The outcome of direct composite restorations using the dental operating microscope
Authors: Bud Marius , Zlăvog Mircea , Jitaru Ștefan , Korkut Bora , Spataru Sergiu , Delean Ada 
Published: October 2021

Background. The objective of the present study was to compare the outcome of direct composite restorations, with and without the use of additional magnification.
Methods. Twenty extracted molars were selected for the study. Class 1 Black cavities were prepared. All teeth were etched, and bonding agent was applied. Teeth were assigned randomly into two groups of ten each. Group I: restorations were done without the use of magnification, first by placing a layer of SDR® flow +Bulk Fill Flowable on the base of the cavity, and then restoring the morphology with Ceram.X SphereTEC® One. Group II: the same protocol was applied, but using the dental microscope. Teeth were then evaluated before and after the finishing protocol by 5 dental professionals using a series of established criteria. The results were documented and statistically analyzed using the non-parametric Mann-Whitney test.
Results. Statistically significant differences were found when using magnification, before the polishing protocol in “marginal adaptation integrity” and “excess material”, and after polishing in “marginal adaptation integrity”.
Conclusions. Magnification may be used to increase the quality of the final direct posterior restoration by improving the marginal adaptation integrity, reducing excess material, preventing marginal microleakage, and avoiding subsequent failure.
Kantian Moral Agency and the Ethics of Artificial Intelligence
Authors: Manna Riya , Nath Rajakishore 
Published: October 2021

This paper discusses the philosophical issues pertaining to Kantian moral agency and artificial intelligence (AI). Here, our objective is to offer a comprehensive analysis of Kantian ethics to elucidate the non-feasibility of Kantian machines. Meanwhile, the possibility of Kantian machines seems to contend with the genuine human Kantian agency. We argue that in machine morality, ‘duty’ should be performed with ‘freedom of will’ and ‘happiness’ because Kant narrated the human tendency of evaluating our ‘natural necessity’ through ‘happiness’ as the end. Lastly, we argue that the Kantian ‘freedom of will’ and ‘faculty of choice’ do not belong to any deterministic model of ‘agency’ as these are sacrosanct systems. The conclusion narrates the non-feasibility of Kantian AI agents from the genuine Kantian ethical outset, offering a utility-based Kantian ethical performer instead.