bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of the efflux pump inhibitor Carbonyl Cyanide m-Chlorophenylhydrazone (CCCP) on the susceptibility to imipenem and cefepime in clinical strains of Acinetobacter baumannii
Authors: Sanchez-Carbonel Alejandra , Mondragón Belén , López-Chegne Nicolás , Peña-Tuesta Isaac , Huayan-Dávila Gladys , Blitchtein Dora , Carrillo-Ng Hugo , Silva-Caso Wilmer , Aguilar-Luis Miguel Angel , del Valle-Mendoza Juana 
Published: December 2021

Introduction
In the last years the rapid expansion of multidrug-resistant A. baumannii strains have become a major health problem. Efflux pumps are a group of transport proteins that contribute to the development of antibiotic resistance. The aim of this study was to evaluate the effect of the efflux pump inhibitor carbonyl cyanide 3-chlorophenylhydrazone (CCCP) on the antimicrobial action of imipenem and cefepime on clinical strains of A. baumannii.

Materials and methods
A total of 49 non-duplicate clinical samples were collected during January through December of 2018 from patients hospitalized in the Hospital Regional Docente de Cajamarca. Of the 49 samples obtained, the confirmatory identification of A. baumannii was performed on 47 samples by molecular methods. The amplification of the blaOXA-51-like gene was carried out by polymerase chain reaction (PCR). The determination of the minimum inhibitory concentration (MIC) was calculated using the microdilution method in culture broth. The susceptibility to both antibiotics (cefepime and imipenem) was evaluated in the presence and absence of the inhibitor carbonyl cyanide 3-chlorophenylhydrazone (CCCP).

Results
A total of 47 strains of A. baumannii were isolated: 97.87% (46/47) were resistant to Imipenem, 2.13% (1/47) of them were classified as intermediate and none of these strains were susceptible. On the other hand, 51.06% (24/47) of isolates were resistant to cefepime; 19.15% (9/47) intermediate and 29.79% (14/47) susceptible. We considered a significant difference in antibiotic susceptibility if the MIC changed at least 4 dilutions, after the addition of the inhibitor. In the case of CCCP in addition to imipenem, 2.1% (1/47) had a significant change of 4 or more reductions in MIC, 59.6% (28/47) achieved a change equal or less than 3 dilutions and 17.0% (8/47) did not have any change. In the case of CCCP with cefepime the percentage of strains with the significant change of MIC was 8.5% (4/47). On the other hand, 53.2% (24/47) presented a reduction equal or less than 3 dilutions and 12.8% (6/47) did not show changes.

Conclusion
In conclusion, our results demonstrate that the use of CCCP may improve the antibiotic effect of imipenem and cefepime on clinical strains of A. baumannii. The relevance of this study is that it provides evidence that this efflux pump inhibitor may be an alternative treatment against multidrug-resistant A. baumannii.
Technical efficiency evaluation of colorectal cancer care for older patients in Dutch hospitals
Authors: Heil Thea C. , Melis René J. F. , Maas Huub A. A. M. , van Munster Barbara C. , Olde Rikkert Marcel G. M. , de Wilt Johannes H. W. , Adang Eddy M. M. ,   on behalf of the PRECOLO consortium
Published: December 2021

Background
Preoperative colorectal cancer care pathways for older patients show considerable practice variation between Dutch hospitals due to differences in interpretation and implementation of guideline-based recommendations. This study aims to report this practice variation in preoperative care between Dutch hospitals in terms of technical efficiency and identifying associated factors.

Methods
Data on preoperative involvement of geriatricians, physical therapists and dieticians and the clinicians’ judgement on prehabilitation implementation were collected using quality indicators and questionnaires among colorectal cancer surgeons and specialized nurses. These data were combined with registry-based data on postoperative outcomes obtained from the Dutch Surgical Colorectal Audit for patients aged ≥75 years. A two-stage data envelopment analysis (DEA) approach was used to calculate bias-corrected DEA technical efficiency scores, reflecting the extent to which a hospital invests in multidisciplinary preoperative care (input) in relation to postoperative outcomes (output). In the second stage, hospital care characteristics were used in a bootstrap truncated regression to explain variations in measured efficiency scores.

Results
Data of 25 Dutch hospitals were analyzed. There was relevant practice variation in bias-corrected technical efficiency scores (ranging from 0.416 to 0.968) regarding preoperative colorectal cancer surgery. The average efficiency score of hospitals was significantly different from the efficient frontier (p = <0.001). After case-mix correction, higher technical efficiency was associated with larger practice size (p = <0.001), surgery performed in a general hospital versus a university hospital (p = <0.001) and implementation of prehabilitation (p = <0.001).

Conclusion
This study showed considerable variation in technical efficiency of preoperative colorectal cancer care for older patients as provided by Dutch hospitals. In addition to higher technical efficiency in high-volume hospitals and general hospitals, offering a care pathway that includes prehabilitation was positively related to technical efficiency of hospitals offering colorectal cancer care.
Hospitalization for ischemic stroke was affected more in independent cases than in dependent cases during the COVID-19 pandemic: An interrupted time series analysis
Authors: Nagano Hiroyuki , Shin Jung-ho , Morishita Tetsuji , Takada Daisuke , Kunisawa Susumu , Fushimi Kiyohide , Imanaka Yuichi 
Published: December 2021

Background
The pandemic of the coronavirus disease 2019 (COVID-19) has affected health care systems globally. The aim of our study is to assess the impact of the COVID-19 pandemic on the number of hospital admissions for ischemic stroke by severity in Japan.

Methods
We analysed administrative (Diagnosis Procedure Combination—DPC) data for cases of inpatients aged 18 years and older who were diagnosed with ischemic stroke and admitted during the period April 1 2018 to June 27 2020. Levels of change of the weekly number of inpatient cases with ischemic stroke diagnosis after the declaration of state of emergency were assessed using interrupted time-series (ITS) analysis. The numbers of patients with various characteristics and treatment approaches were compared. We also performed an ITS analysis for each group (“independent” or “dependent”) divided based on components of activities of daily living (ADL) and level of consciousness at hospital admission.

Results
A total of 170,294 cases in 567 hospitals were included. The ITS analysis showed a significant decrease in the weekly number of ischemic stroke cases hospitalized (estimated decrease: −156 cases; 95% confidence interval (CI): −209 to −104), which corresponds to −10.4% (95% CI: −13.6 to −7.1). The proportion of decline in the independent group (−21.3%; 95% CI: −26.0 to −16.2) was larger than that in the dependent group (−8.6%; 95% CI: −11.7 to −5.4).

Conclusions
Our results show a marked reduction in hospital admissions due to ischemic stroke after the declaration of the state of emergency for the COVID-19 pandemic. The independent cases were affected more in proportion than dependent cases.
Punkzines: British Fanzine Culture from the Punk Scene 1976–1983, Eddie Piller and Steve Rowland (2021)
Authors: Bestley Russ 
Published: December 2021

Review of: Punkzines: British Fanzine Culture from the Punk Scene 1976–1983, Eddie Piller and Steve Rowland (2021)
London: Omnibus Press, 176 pp.,
ISBN 978-1-91317-213-8, p/bk, £16.99
Monolithic Undertow: In Search of Sonic Oblivion, Harry Sword (2021)
Authors: Loydell Rupert 
Published: December 2021

Review of: Monolithic Undertow: In Search of Sonic Oblivion, Harry Sword (2021)
London: White Rabbit, 455 pp.,
ISBN 978-1-47461-523-5, h/bk, £20
The influence of ground slab permeability on wall moisture in a historic building
Authors: Briggs Kevin , Ball Richard , McCaig Iain 
Published: December 2021

When impermeable ground bearing slabs are installed in old buildings without a damp-proof course, it is a common belief of practitioners within the conservation industry that ground moisture will be ‘driven’ up adjacent walls by capillary action. However, there is limited evidence to test this hypothesis. The accumulation of moisture in walls can promote the decay of the wall materials, decrease the thermal performance of the building envelope and adversely affect the comfort and health of occupants.
An experiment was used to determine if the installation of a vapour-proof barrier above a stone flag floor in a historic building would increase moisture content levels in an adjacent stone rubble wall. This was achieved by undertaking measurements of wall, soil and atmospheric moisture content over a three-year period. Measurements taken using timber dowels showed that the moisture content within the wall did not vary in response to wall evaporation rates and did not increase following the installation of a vapour-proof barrier above the floor. This indicates that the moisture levels in the rubble wall were not driven by capillary rise.
Propozycja rozwiązania problemu trafu moralnego w kontekście zasady kontroli
Authors: STRZYŻYŃSKI PRZEMYSŁAW 
Published: December 2021

Artykuł prezentuje propozycję rozwiązania problemu trafu moralnego, w kontekście zasady kontroli. Zasada ta mówi, że warunkiem przypisania odpowiedzialności, winy/zasługi moralnej jest posiadanie kontroli nad działaniem przez sprawcę. Traf moralny powoduje zdaniem jego zwolenników, że ocenie moralnej podlega działanie podmiotu, które było zakłócone przez przypadek, czy czynnik będący poza kontrolą podmiotu. W artykule próbuje się wykazać, że nie można mówić o całkowitym braku kontroli w działaniach, na które wpływa przypadek. Stąd nie można wysuwać tak dalekich konsekwencji oddziaływania trafu na moralność jak negacja sensowności przypisywania odpowiedzialności moralnej i winy/zasługi w ogóle. W to miejsce proponuje się w artykule oddzielnie przypisywania odpowiedzialności moralnej od winy/zasługi, w zależności od intencji podmiotu działającego.
Monte Carlo Method–Based Tool Life Prediction during the End Milling of Ti-6Al-4V Alloy for Smart Manufacturing
Authors: Tiwari K. , Arunachalam N. 
Published: December 2021

Abstract
Tool wear prediction during machining is of significant interest for the development of intelligent functionalities in manufacturing industry. A data-driven Bayesian Monte Carlo–based probabilistic approach is used for predicting the wear of TiAlN-coated carbide inserts during the end milling of Ti-6Al-4V alloy. A series of slot milling passes at varying combinations of speed, feed, and depth of cut were conducted, and wear was measured after each pass. Each insert was used for successive passes at a particular cutting condition until the flank wear crosses the failure threshold of 0.3 mm of average flank wear. The wear estimation from the model is good at tracking wear growth for the unknown data sets, which can provide a timely tool change command before the tool failure. This model thus leads to the formulation of an adaptive control strategy for timely replacement of cutting tools for optimal machining.
Saturating Nonlinearities of Contrast Response in Human Visual Cortex
Authors: Vinke Louis N. , Bloem Ilona M. , Ling Sam 
Published: December 2021

Response nonlinearities are ubiquitous throughout the brain, especially within sensory cortices where changes in stimulus intensity typically produce compressed responses. Although this relationship is well established in electrophysiological measurements, it remains controversial whether the same nonlinearities hold for population-based measurements obtained with human fMRI. We propose that these purported disparities are not contingent on measurement type and are instead largely dependent on the visual system state at the time of interrogation. We show that deploying a contrast adaptation paradigm permits reliable measurements of saturating sigmoidal contrast response functions (10 participants, 7 female). When not controlling the adaptation state, our results coincide with previous fMRI studies, yielding nonsaturating, largely linear contrast responses. These findings highlight the important role of adaptation in manifesting measurable nonlinear responses within human visual cortex, reconciling discrepancies reported in vision neuroscience, re-establishing the qualitative relationship between stimulus intensity and response across different neural measures and the concerted study of cortical gain control.SIGNIFICANCE STATEMENTNonlinear stimulus–response relationships govern many essential brain functions, ranging from the sensory to cognitive level. Certain core response properties previously shown to be nonlinear with nonhuman electrophysiology recordings have yet to be reliably measured with human neuroimaging, prompting uncertainty and reconsideration. The results of this study stand to reconcile these incongruencies in the vision neurosciences, demonstrating the profound impact adaptation can have on brain activation throughout the early visual cortex. Moving forward, these findings facilitate the study of modulatory influences on sensory processing (i.e., arousal and attention) and help establish a closer link between neural recordings in animals and hemodynamic measurements from human fMRI, resuming a concerted effort to understand operations in the mammalian cortex.
Quality Initiative to Increase Delivery of Adolescent Hospital-Based Reproductive Health Care
Authors: McFadden Vanessa , Bauer Sarah Corey , Porada Kelsey , Mehta Sonia , Pickett Michelle L. 
Published: December 2021

OBJECTIVES
Hospitals are an important nontraditional setting in which to address adolescent reproductive health. However, opportunities for intervention are frequently missed, especially for boys and patients hospitalized for noningestion complaints. Our global aim was to increase delivery of reproductive health care to adolescents hospitalized through our children’s hospital Pediatric Hospital Medicine service.

METHODS
We performed 2 quality improvement intervention cycles: (1) provider education and monthly reminder e-mails and (2) an automated electronic health record (EHR) adolescent history and physical note template with social history prompts while discontinuing reminder e-mails. The primary outcome measure was sexual history documentation (SHD). Secondary measures were sexually transmitted infection (STI) testing and contraception provision. Statistical process control charts were used to analyze effectiveness of interventions.

RESULTS
From July 2018 through June 2019, 528 Primary Hospital Medicine encounters were included in this study and compared with published baseline data on 150 encounters. Control charts revealed a special cause increase in SHD from 60% to 82% overall, along with 37% to 73% for boys and 57% to 80% for noningestion hospitalizations. Increased SHD correlated with cycle 1 and was maintained through cycle 2. Percent STI testing significantly increased but did not shift or trend toward special cause variation. Contraception provision, length of stay, and patient relations consultations were not affected.

CONCLUSIONS
The interventions were successful in increasing SHD, including among boys and noningestion hospitalizations. The EHR enhancement maintained these increases after reminder emails were discontinued. Future interventions should specifically address STI testing and provision of contraception.
Addressing Transportation Insecurity Improves Attendance at Posthospitalization Appointments
Authors: Hoffman Sarah C. , Buczkowski Amy S. , Mallory Leah , McGovern Lauren B. , Cappen Shannon M. , Douglass Amy S. , Correia Russell , Longnecker Lee , Taylor Campbell S. , Holmes Rebekah , Poulin Brogan , McElwain Lorraine L. 
Published: December 2021

BACKGROUND
Transportation influences attendance at posthospitalization appointments (PHAs). In 2017, our pediatric hospital medicine group found that our patients missed 38% of their scheduled PHAs, with several being due to transportation insecurity. To address this, we implemented a quality improvement project to perform inpatient assessment of transportation insecurity and provide mitigation with the goal of improving attendance at PHAs.

METHODS
The process measure was the percentage of patients with completed transportation insecurity screening, and the outcome measure was PHA attendance. An interprofessional team performed plan-do-study-act cycles. These included educating staff about the significance of transportation insecurity, its assessment, and documentation; embedding a list of local transportation resources in discharge instructions and coaching families on using these resources; notifying primary care providers of families with transportation insecurity; and auditing PHA attendance.

RESULTS
Between July 2018 and December 2019, electronic health record documentation of transportation insecurity assessment among patients on the pediatric hospital medicine service and discharged from the hospital (n = 1731) increased from 1% to 94%, families identified with transportation insecurity increased from 1.2% to 5%, and attendance at PHAs improved for all patients (62%–81%) and for those with transportation insecurity (0%–57%). Our balance measure, proportion of discharges by 2 pm, remained steady at 53%. Plan-do-study-act cycles revealed that emphasizing PHA importance, educating staff about transportation insecurity, and helping families identify and learn to use transportation resources all contributed to improvement.

CONCLUSIONS
Interventions implemented during the inpatient stay to assess for and mitigate transportation insecurity led to improvement in pediatric PHA attendance.
Implications of University-Business Cooperation for Higher Education in a Time of Cybernetics: Emerging Trends and Dilemmas
Authors: Tarasevich I. G. , Tarasevich A. 
Published: December 2021

Universities and business collaborate for their own ends that do not necessarily match. While the industry is always profit-driven and practice-oriented with primarily short-term goals in mind, the university focuses on strategic planning, theory development, and long-term goals. University-business collaboration (UBC) has diverse modes or activities among which the most common are: 1) research and development (R&D); 2) mobility of academic staff; 3) student mobility; 4) curriculum development and delivery; 5) lifelong learning. While the focus of UBC is on conducting practice-oriented research, each university and enterprise have their own unique combinations of activities that reflect their goals and needs. All the five collaborative research activities demonstrate different effects with UBC drivers, barriers, and organizational characteristics that are further explored in the article.
Similar to automation, higher education is in many ways a stochastic adaptive control system, the behaviour of which depends on parameters with unknown values. The system has to perform in order to collect specific values of these parameters. The values are crucial as, once collected, they can be used to alter the system’s performance. Following this logic, we consider the five modes specified above as key UBC parameters, put in their emerging trends as parameters’ values, and consider emerging dilemmas and implications for higher education. The key challenge nowadays is around the adaptability of higher education. More than ever before, educators around the world grapple with the idea of whether and how adaptive the modern university should be to the business world needs in the context of global automation. This article is our attempt to add to a meaningful debate around this topic.
Competitividad de las empresas PyMes al implementar la factura electrónica
Authors: Muñoz Villegas Aneth Magreth , Mosquera Carrascal Adriana 
Published: December 2021

Objetivo: En este estudio se determinó el efecto de la implementación de la factura electrónica sobre la competitividad en las empresas PyMes en la comercialización de bienes y servicios. Método: el tipo de investigación es de carácter cuantitativo–explicativo, se realizó encuestas a los representantes legales de las empresas PyMes, aplicando la matriz de lado a lado de análisis de datos, para medirla e interpretarla. Resultados: Se evidencia el impacto positivo en la innovación de la organización al utilizar la factura electrónica; mejora el canal de comunicación y el servicio al cliente; incrementa la productividad; su utilización proporciona ventaja competitiva al disminuir los costos y al aumentar la competitividad, producto de la innovación, servicio, rapidez y productividad. Conclusión: Tanto la investigación como los autores teóricos coinciden en que la utilización de la factura electrónica permite a las empresas un servicio ágil; reduce reprocesos administrativos aumenta la productividad de los empleados; mejora e incrementa los servicios con la tecnología¸ y trae muchos efectos positivos a la organización.
“I may be essential but someone has to look after my kids”: women physicians and COVID-19
Authors: Smith Julia , Abouzaid Lina , Masuhara Joy , Noormohamed Salima , Remo Neli , Straatman Lynn 
Published: December 2021

Abstract
Objectives
This paper analyzes results from focus groups held with women physicians in British Columbia which explored questions around how gender norms and roles influenced their experiences during COVID-19.

Methods
Four virtual focus groups were organized between July and September 2020. Participants (n = 27) were voluntarily recruited. Data were analyzed using applied thematic analysis.

Results
In addition to the COVID-19-related changes experienced across the profession, women physicians faced distinct challenges related to an increase in unpaid care responsibilities, and often felt excluded from, and occasionally dismissed by, leadership. Women leaders often felt their contributions were unrecognized and undervalued. Participants drew strength from other women leaders, peer networks, and professional support, but these strategies were limited by unpaid care and emotional labour demands, which were identified as increasing risk of burnout.

Discussion
Even though women physicians hold a degree of relative privilege, unpaid care work and gender norms contribute to distinct secondary effects of COVID-19. Women physicians link these to pre-pandemic assumptions (within families and communities) that women would absorb care deficits at their own cost. Health system leadership continues to reflect a masculine normative experience wherein the personal and professional are separated, and which devalues the emotional labour often associated with feminine leadership. The strategies participants employed to address negative impacts, while demonstrating resourcefulness and peer support, reflect individualistic responses to social-structural challenges. There is a need for greater recognition of women’s contributions at home and work, increased representation in decision-making, and practical supports such as childcare and counselling.