bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Cost-Effectiveness Analysis of Lung Cancer Screening With Low-Dose Computed Tomography and a Diagnostic Biomarker
Authors: Toumazis Iakovos , Erdogan S Ayca , Bastani Mehrad , Leung Ann , Plevritis Sylvia K 
Published: October 2021

Abstract

Background
The Lung Computed Tomography Screening Reporting and Data System (Lung-RADS) reduces the false-positive rate of lung cancer screening but introduces prolonged periods of uncertainty for indeterminate findings. We assess the cost-effectiveness of a screening program that assesses indeterminate findings earlier via a hypothetical diagnostic biomarker introduced in place of Lung-RADS 3 and 4A guidelines.

Methods
We evaluated the performance of the US Preventive Services Task Force (USPSTF) recommendations on lung cancer screening with and without a hypothetical noninvasive diagnostic biomarker using a validated microsimulation model. The diagnostic biomarker assesses the malignancy of indeterminate nodules, replacing Lung-RADS 3 and 4A guidelines, and is characterized by a varying sensitivity profile that depends on nodules' size, specificity, and cost. We tested the robustness of our findings through univariate sensitivity analyses.

Results
A lung cancer screening program per the USPSTF guidelines that incorporates a diagnostic biomarker with at least medium sensitivity profile and 90% specificity, that costs $250 or less, is cost-effective with an incremental cost-effectiveness ratio lower than $100 000 per quality-adjusted life year, and improves lung cancer-specific mortality reduction while requiring fewer screening exams than the USPSTF guidelines with Lung-RADS. A screening program with a biomarker costing $750 or more is not cost-effective. The health benefits accrued and costs associated with the screening program are sensitive to the disutility of indeterminate findings and specificity of the biomarker, respectively.

Conclusions
Lung cancer screening that incorporates a diagnostic biomarker, in place of Lung-RADS 3 and 4A guidelines, could improve the cost-effectiveness of the screening program and warrants further investigation.
Weight Stigma and Mental Health in Youth: A Systematic Review and Meta-Analysis
Authors: Warnick Jennifer L , Darling Katherine E , West Caroline E , Jones Laura , Jelalian Elissa 
Published: October 2021

Abstract

Objective
Over the past two decades, there has been a steady increase in research focused on the association between weight-based stigma and mental health outcomes in children and adolescents. The present study is a systematic review and meta-analysis of the associations between weight stigma and mental health in youth.

Methods
A systematic search of PubMed, PsychInfo, and Embase databases was conducted in January 2020. Inclusion criteria included the following: (a) examined an association between weight stigma and a mental health outcome, (b) mean sample age &lt;18 (+1 standard deviation) years, (c) written in English, and (d) peer reviewed. Forty eligible articles were identified. The moderating effects of age, sex (percent female), weight status (percent with overweight/obesity), and study quality were examined.

Results
Overall, meta-analytic findings using a random-effects model indicated a statistically significant moderate association between weight stigma and poorer mental health outcomes (r = .32, 95% confidence interval [0.292, 0.347], p &lt; .001). Age and study quality each moderated the association between weight stigma and mental health. Generally, the study quality was fair to poor, with many studies lacking validated measurement of weight stigma.

Conclusions
Although there was a significant association between weight stigma and mental health in youth, study quality hinders the current body of literature. Furthermore, findings highlight the lack of consideration of internalized weight stigma in child populations, the importance of using validated measures of weight stigma, and the need for increased awareness of how these associations affect populations of diverse backgrounds.
Standardizing reverberation-measured Mg II time-lag quasars, by using the radius–luminosity relation, and constraining cosmological model parameters
Authors: Khadka Narayan , Yu Zhefu , Zajaček Michal , Martinez-Aldama Mary Loli , Czerny Bożena , Ratra Bharat 
Published: October 2021

ABSTRACT
We use 78 reverberation-measured Mg II time-lag quasars (QSOs) in the redshift range 0.0033 ≤ z ≤ 1.89 to constrain cosmological parameters in six different cosmological models. The basis of our method is the use of the radius–luminosity or R−L relation to standardize these 78 Mg II QSOs. In each cosmological model, we simultaneously determine R−L relation and cosmological model parameters, thus avoiding the circularity problem. We find that the R−L relation parameter values are independent of the cosmological model used in the analysis, thus, establishing that current Mg II QSOs are standardizable candles. Cosmological constraints obtained using these QSOs are significantly weaker than, but consistent with, those obtained from a joint analysis of baryon acoustic oscillation (BAO) observations and Hubble parameter [H(z)] measurements. So, we also analyse these QSOs in conjunction with the BAO + H(z) data and find cosmological constraints consistent with the standard spatially flat ΛCDM model as well as with mild dark energy dynamics and a little spatial curvature. A larger sample of higher quality reverberation-measured QSOs should have a smaller intrinsic dispersion and so should provide tighter constraints on cosmological parameters.
The BAHAMAS project: evaluating the accuracy of the halo model in predicting the non-linear matter power spectrum
Authors: Acuto Alberto , McCarthy Ian G , Kwan Juliana , Salcido Jaime , Stafford Sam G , Font Andreea S 
Published: October 2021

ABSTRACT
The halo model formalism is widely adopted in cosmological studies for predicting the growth of large-scale structure in the Universe. However, to date there have been relatively few direct comparisons of the halo model with more accurate (but much more computationally expensive) cosmological simulations. We test the accuracy of the halo model in reproducing the non-linear matter power spectrum, P(k), when the main inputs of the halo model (specifically the matter density profiles, halo mass function, and linear bias) are taken directly from the BAHAMAS simulations, and we assess how well the halo model reproduces P(k) from the same simulations. We show that the halo model generally reproduces P(k) in the deep non-linear regime (1-halo) to typically a few per cent accuracy, but struggles to reproduce (approx. 15 per cent error) P(k) at intermediate scales of $0.1 \la k \ [h/{\rm Mpc}] \la 3$ at $z$ = 0, marking the transition between the 1-halo and 2-halo terms. We show that the magnitude of this error is a strong function of the halo mass definition (through its effects on radial extent of haloes) and of redshift. Furthermore, we test the accuracy of the halo model in recovering the relative impact of baryons on P(k). We show that the systematic errors in recovering the absolute P(k) largely cancel when considering the relative impact of baryons. This suggests that the halo model can make precise predictions for the baryonic suppression, offering a fast and accurate way to adjust collisionless matter power spectra for the presence of baryons and associated processes.
Changes in Pain Catastrophizing and Fear-Avoidance Beliefs as Mediators of Early Physical Therapy on Disability and Pain in Acute Low-Back Pain: A Secondary Analysis of a Clinical Trial
Authors: Sisco-Taylor Brittany L , Magel John S , McFadden Molly , Greene Tom , Shen Jincheng , Fritz Julie M 
Published: October 2021

AbstractObjectiveThe Fear-Avoidance Model (FAM) of chronic pain posits that pain catastrophizing and fear-avoidance beliefs are prognostic for disability and chronicity. In acute low-back pain, early physical therapy (PT) is effective in reducing disability in some patients. How early PT impacts short- and long-term changes in disability for patients with acute pain is unknown. Based on the FAM, we hypothesized that early reductions in pain catastrophizing and fear-avoidance beliefs would mediate early PT’s effect on changes in disability (primary outcome) and pain intensity (secondary outcome) over 3 months and 1 year.SubjectsParticipants were 204 patients with low-back pain of &lt;16 days duration, who enrolled in a clinical trial (NCT01726803) comparing early PT sessions or usual care provided over 4 weeks.MethodsPatients completed the Pain Catastrophizing Scale (PCS), Fear-Avoidance Beliefs Questionnaire (FABQ work and physical activity scales), and outcomes (Oswestry Disability Index and Numeric Pain Rating Scale) at baseline, 4 weeks, 3 months, and 1 year. We applied longitudinal mediation analysis with single and multiple mediators.ResultsEarly PT led to improvements in disability and pain over 3 months but not 1 year. In the single mediator model, 4-week reductions in pain catastrophizing mediated early PT’s effects on 3-month disability and pain intensity improvements, explaining 16% and 22% of the association, respectively, but the effects were small. Pain catastrophizing and fear-avoidance beliefs did not jointly mediate these associations.ConclusionsIn acute low-back pain, early PT may improve disability and pain outcomes at least partly through reducing patients’ catastrophizing.
Ultrasound Evaluation of the Respiratory Variations of the Internal Jugular Vein Compared to the Respiratory Variations of the Inferior Vena Cava as a Guidance of Fluid Responsiveness in Septic Shock
Authors: Ali Khalil Ahmed Abd Elalim , Elkadi . Galal Adel Mohamed , Anies Saeid Sherif George , Saleh Gamal Eldin Adel Abd Elhameed 
Published: October 2021

Abstract

Background
Septic shock is one of the most complex hemodynamic failure syndromes. It is the major cause of mortality and morbidity in intensive care unit. Fluid resuscitation is of paramount importance in septic shock. However, its correction should be carefully guided to avoid unnecessary volume expansion. Ultra- sonographic evaluation of fluid responsiveness plays an important role in septic shock.

Objectives
The objective of the study was to verify the feasibility and usefulness of the internal jugular vein distensibility index in prediction of fluid responsiveness in septic shock patients undergoing mechanical ventilation compared to the inferior vena cava distensibility index.

Methodology
The study was carried out in Ain Shams University Hospital from February 2019 to November 2019, on twenty patients 20 patients of both sex who were admitted to the intensive care unit and diagnosed as septic shock (sepsisinduced hypotension persisting despite adequate fluid resuscitation and require vasopressors and serum lactate &gt; 2 mmol/ L) As regard the hemodynamic parameters, patients were classified into two groups: Fluid responders and non-fluid responders.

Results
The study demonstrated that there was a positive correlation between internal jugular vein distensibility index (IJV DI) and inferior vena cava distensibility index (IVC DI) in prediction of fluid responsiveness. IVC DI index cutoff value was &gt; 12.6% with sensitivity 80% and specificity 80% and IJV DI cut off value was &gt;8.4% with sensitivity 86.67% and specificity 80%.

Conclusion
ultra-sonographic assessment of the internal jugular vein distensibility index (IJV DI) and inferior vena cava distensibility index (IVC DI) are useful dynamic indices in assessment of the intravascular volume state in mechanically ventilated septic shock patients. IJV and IVC show comparable value in the prediction of fluid responsiveness.
Ultrasound Guided Quadratus Lumborum Block versus Transversus Abdominis Plane Block in Post-Operative Pain Management after Cesarean Section
Authors: Elsafty Omar Mohamed Taha , Awad Hanan Mahmoud Farag , Ahmed Mohamed Saleh , Mahdy Ahmed Elkholy 
Published: October 2021

Abstract

Background
Cesarean section rate increased those days and postoperative pain control. The goal of postoperative pain management is provision of comfort, early mobilization and improved respiratory function without causing inadequate sedation and respiratory compromise, which can be achieved through using multimodal analgesic therapy, preference for regional techniques, avoidance of sedatives, non-invasive ventilation with supplemental oxygen and early mobilization.

Objectives
The aim of this study was to assess the analgesic efficacy of ultrasound-guided trans-muscular QLB compared with TAP block after cesarean section surgeryperiod regarding pain relief, provision of comfort, and improved respiratory functions.

Patients and Methods
After approval of anesthesiology department scientific and ethical committees in Ain Shams University Hospitals, female patients were included in the study, and were divided into three groups (n = 20; each); group QLB and group TAP. Group QLB: Patients (n = 20) of this group received bilateral ultrasound-guided QLB after induction of general anesthesia using 0.2 ml/kg bupivacaine 0.125%, Group TAP: Patients (n = 20) of this group received bilateral ultrasound-guided TAP block after induction of general anesthesia using 0.2 ml/kg bupivacaine 0.125%.

Results
The current study also measured and compared postoperative VAS score and firs time to rescue analgesia and the total amount of opioid (pethidine) given in the first 24 hours with the standard deviation for each of the two groups studied we found that TAP patients had the highest values compared to the QLB group. This is mainly due to the extension of the local anesthetic agent beyond the transverse abdominal plane to the thoracic paravertebral space, which then results in more analgesia, even somatic and visceral pain control.

Conclusion
Quadratus lumborum block was the most effective technique in providing analgesia after cesarean section without associated hemodynamic instability in comparison to transversus abdominis plane block and even more time covering to rescue opioid.
A Comparative Study of Preemptive Effect of Pregabalin and Gabapentin on Postoperative Pain After Coronary Artery Bypass Graft Surgery
Authors: Abdelaziz Mohamed Saeed , Mohamed Randa Ali Shoukry , Ismail Mohamed Abdelmohsen Abdelnaeim , Mohamed Ahmed Nabil Ahmed Talaat 
Published: October 2021

Abstract

Background
Pain that pursues coronary artery bypass graft (CABG) surgery is usually associated with increased both recovery duration and hospital stay. Patient outcome could be worsened owing to large doses of opioids for pain control through over sedation, and prolonged mechanical ventilation. This study was designed to evaluate the effect of preemptive gabapentinoids on post CABG surgery pain control.

Objective
to evaluate the effect of pre-operative administration of pregabalin and gabapentin in limiting the post-operative pain in coronary artery bypass surgeries.

Patients and Methods
Type of Study: Prospective double – blinded, randomized controlled Trial. After Approval is obtained from the research ethics committee of anesthesia and intensive care department, Ain Shams University. Study Setting: National Heart Institute, Egypt. Study Period: 6 months. Study Population: adult undergoing coronary artery bypass graft surgeries.

Results
The primary outcome of this study was to compare the effect of gabapentinoids on post CABG pain as reflected by morphine consumption. The secondary outcome was to address the influence of gabapentinoids on patient satisfaction post CABG, the incidence of respiratory depression, nausea, vomiting, ventilatory hours and length of hospital stay.

Conclusion
Pregabalin, and gabapentin both can be effective for reduction of post CABG morphine consumption and have better patient satisfaction if given preemptively with single dose preoperatively.
Evaluation of red cell distribution width (RDW) as a septic marker in comparison with clinical scores and C-reactive protein
Authors: Naga Ali Ahmed , Fattah Mohammed Ismaeil Abdel , Nofal Walid Hamed , AlMenshawe Mohammed Abd-elsalam 
Published: October 2021

Abstract

Background
Challenges of diagnosing and treating sepsis only seem more difficult as incidence increases, patients become older and sicker, and pathogenic organisms evolve. New understanding of inflammatory mediators and pathways, immunity, and genetic variability in this disease state suggests that the current definitions of SIRS, sepsis, severe sepsis, and septic shock are oversimplified.

Objective
The aim of our study is to evaluate the level of RDW, CRP and clinical scores "SOFA and APACHI" as markers in patients with sepsis and their levels on the outcome and resolution of sepsis in ICU.

Methodology
We conducted a prospective observational controlled study on 90 adult persons of both sex, 45 of them are adult patients and served as the study group (Group I), and the other 45 are healthy adult volunteers and served as the control group (Group II). The study group represented patients admitted to the ICU of Intensive Care Unit at Damanhour Medical National Institute who fulfilled the diagnostic criteria for sepsis, severe sepsis and septic shock on arrival to ICU according to the SCCM/ ESICM/ ACCP/ ATS/SIS International Sepsis Definitions Conference.

Results.
In the present study we found that CRP measured on admission was not a predictor of mortality, while that measured at day 5 and day 10 predicted mortality, where there was no statistically significant difference in CRP levels between survivors and non-survivors at the day of admission while there were statistically significant differences between survivors and non survivors according to CRP levels at day 5 (p = 0.001*) and at day 10 (p = 0.001*). It was found also that there were statistically significant differences between survivors and non-survivors according to RDW at day 1(p = 0.011*) and at day 5(p = 0.009*), at day 10 was found there was no statistically significant difference between survivors and non-survivors (p = 0.338).

Conclusion
RDW is a new promising cheap and readily available biomarker that can be able to diagnose patients with sepsis with accuracy comparable to CRP. Also, RDW at admission is able to predict mortality.
Single Intravenous Bolus versus Continuous Infusion of Tranexamic Acid to Reduce Blood Loss in Transurethral Resection of Prostate: a Prospective Randomized Double-Blind Study
Authors: Ghaly Safaa I , Khairy Marwa A , Kamal Mohamed M , Mohammed Eman A 
Published: October 2021

Abstract

Background and aim
Intraoperative use of a single bolus dose of tranexamic acid may not be sufficient to prevent bleeding in the early postoperative period. The present study was carried out to compare the effect of two dose regimens of tranexamic acid in reducing perioperative blood loss and the amount of allogeneic blood transfusion in transurethral resection of prostate.

Design
prospective, double-blinded and controlled study.

Setting
Ain Shams University Hospital,

Patients and Methods
50 patients electively posted for transurethral resection of prostate were randomly assigned to receive a single bolus dose of tranexamic acid (10 mg/kg) (Group A), a bolus dose of tranexamic acid (10 mg/kg) followed by infusion (1 mg/kg/h) till 4 h postoperatively (Group B).

Measurements
Total intraoperative blood loss, amount of allogeneic blood transfusion, postoperative drain collections, and hemoglobin and hematocrit levels were recorded at different time intervals. Data obtained after comparing two groups were analyzed using the statistical package for social sciences.

Results
There was no statistically significant difference among patients in both groups regarding intraoperative blood loss and postoperative blood loss at 6 hrs and 48 hrs postoperatively. However the post-operative blood loss at 24 hrs was significantly higher among patients in group A than patients in group B (P-value= 0.014) .

Conclusion
Tranexamic acid causes more effective reduction in post-operative blood loss when used as a bolus followed by an infusion continued in the postoperative period in comparison to its use as a single intravenous bolus in transurethral resection of prostate.
Comparative Study between two Ultrasound Aided Methods in PreoperativeAssessment of Difficult Airway in Obese Patients
Authors: Saleh Galal Aboul-so’od , George Sherif Anis , Abdelhamid Gamal Eldin Adel , Swedan Hazem Sameer 
Published: October 2021

Abstract

Background
Unpredictable difficult laryngoscopy remains a challenge for anaesthesiologists, especially if difficult ventilation occurs. So, accurate airway assessment should always be performed so as to provide appropriate planning and management of expected difficult intubation and to limit any unexpected difficulties. Airway assessment using ultrasound has been proposed recently as a useful, simple and non-invasive bed side tool as an adjunct to clinical methods.

Objective
To establish whether correlations existed between two ultrasound measurements and the Cormack–Lehane grade during direct laryngoscopy, and whether these measurements are useful in predicting are stricted or difficult view especially in morbid obese individuals. The first is the measurement of the hyomental distance of the patient in neutral position of the neck and in fully extended neck calculating the ratio between both of them. While the second is the measurement of anterior cervical soft tissue thickness at three anatomical levels (hyoid bone, thyrohyoid membrane or ‘pre epiglottic space’ and anterior commissure). We chose these two new measurements from among the various ultrasound assessments made in previous studies because of their simplicity of execution in normal clinical and in emergency settings.

Patients and Methods
The current study is a prospective comparative clinical trial of assessment of difficult air way using two different ultrasound aided techniques in comparison to Cormack and lehane scoring system. Those patients were chosen upon some inclusion and exclusion criteria; inclusion criteria were (Age of the patient (25-60y), ASA I-II patients, Obese patients with body mass index &gt; 30 kg /m2 and Pts undergoing bariatric surgery) and exclusion criteria were (Pathology of the airway (tumors), Deformity of the airway anatomy (burns, scars), History of facial, cervical, pharyngeal and epiglottis surgery or trauma, Patients with most teeth lost and Patient refusal).

Results
Regarding U/S measurements in method A patients; the average HMD-neutral of A patients was (53.58±5.33) mm, the average HMD-extension was (58±7.82) mm, and the average HMDR was (1.07±0.06). It showed highly significant decrease in HMD extension and HMDR in difficult group, compared to easy group, in A group of patients (p &lt; 0.01respectively). Non-significant difference as regards HMD-neutral U/S measurements in method A (p &gt; 0.05).

Conclusion
Ultrasonography can be a valuable adjunct in this aspect of airway assessment. Ultrasound assessment of pre-epiglottic tissue thickness at the level of the thyrohyoid membrane may be useful to predict restricted/difficult direct laryngoscopy and difficult intubation. The ratio of hyomental distance between neutral and extended positions may also be a good predictor of difficult direct laryngoscopy.