bluuebunny/crossref_metadata_2025_split huggingface dataset:
N-Demethylsinomenine, an Active Metabolite of Sinomenine, Attenuates Chronic Neuropathic and Inflammatory Pain in Mice
Authors: Zhou Zhiyong , Qiu Nanqing , Ou Yuntao , Wei Qianqian , Tang Wenting , Zheng Mingcong , Xing Yaluan , Li Jie-Jia , Ling Yong , Li Junxu , Zhu Qing 
Published: February 2021

Abstract
Chronic pain is a significant public health problem that afflicts nearly 30% of the global population, but current pharmacotherapies are insufficient. Previous report indicated that N-demethylsinomenine, an active metabolite of sinomenine, is efficacious against postoperative pain. The present study investigated whether N-demethylsinomenine is effective for chronic painful conditions or whether repeated treatment alters its effect. Both chronic constriction injury (CCI) surgery and complete Freund’s adjuvant (CFA) intraplantar injection induced significant and reliable mechanical allodynia at least for 7 days. Acute treatment with N-demethylsinomenine (10–40 mg/kg, i.p.) dose-dependently attenuated the mechanical allodynia both in CCI-induced neuropathic pain and CFA-induced inflammatory pain in mice. The potent of N-demethylsinomenine for reducing CFA-induced mechanical allodynia was slightly higher than sinomenine. During the period of repeated treatment, N-demethylsinomenine maintained its anti-allodynic effect against both neuropathic and inflammatory pain without producing carry-over effect. Pretreatment with bicuculline, a selective γ-aminobutyric acid type A (GABAA) receptor antagonist, almost completely blocked the anti-allodynia of N-demethylsinomenine (40 mg/kg) both in CCI and CFA-treated mice. Our findings indicated that N-demethylsinomenine exhibits GABAA receptor-mediated anti-allodynic effects in mouse models of neuropathic and inflammatory pain, suggesting it may be a useful novel pharmacotherapy for the control of chronic pain.Chemical compounds studied in this article:sinomenine (PubChem CID: 5459308), N-demethylsinomenine (PubChem CID: 9861678), bicuculline (PubChem CID: 10237)
Fecal Calprotectin is a Useful Biomarker for Predicting the Clinical Outcome of Granulocyte and Monocyte Adsorptive Apheresis in Ulcerative Colitis Patients: A Prospective Observation Study.
Authors: Ueno Nobuhiro , Sugiyama Yuya , Kobayashi Yu , Murakami Yuki , Iwama Takuya , Sasaki Takahiro , Kunogi Takehito , Takahashi Keitaro , Tanaka Kazuyuki , Ando Katsuyoshi , Kashima Shin , Inaba Yuhei , Moriichi Kentaro , Tanabe Hiroki , Taruishi Masaki , Saitoh Yusuke , Okumura Toshikatsu , Fujiya Mikihiro 
Published: February 2021

Abstract
Background: Granulocyte and monocyte adsorptive apheresis (GMA) is widely used as a remission induction therapy for active ulcerative colitis (UC) patients. However, there are no available biomarkers for predicting the clinical outcome of GMA. We investigated the utility of Fecal calprotectin (FC) as a biomarker for predicting the clinical outcome during GMA therapy in active UC patients.Methods: In this multicenter prospective observation study, all patients received 10 sessions of GMA, twice a week, for 5 consecutive weeks. FC was measured at entry, one week, two weeks, and at the end of GMA. Colonoscopy was performed at entry and after GMA. The clinical activity was assessed based on the partial Mayo score when FC was measured. Clinical remission (CR) was defined as a partial Mayo score of ≤2 and endoscopic remission (ER) was defined as Mayo endoscopic subscore of either 0 or 1. We analyzed the relationships between the clinical outcome (CR and ER) and the change in FC concentration.Result: Twenty-six patients were included in this study. The overall CR and ER rates were 50.0% and 19.2%, respectively. After GMA, the median FC concentration in patients with ER was significantly lower than that in patients without ER (469 mg/kg vs. 3107 mg/kg, p=0.03). When the cut-off value of FC concentration was set at 1150 mg/kg for assessing ER after GMA, the sensitivity and specificity were 0.8 and 0.81, respectively. The FC concentration had significantly decreased by one week. An ROC analysis demonstrated that the reduction rate of FC (ΔFC) at 1 week was the most accurate predictor of CR at the end of GMA (AUC=0.852, P=0.002). When the cut-off value of ΔFC was set at ≤40% at 1 week for predicting CR at the end of GMA, the sensitivity and specificity were 76.9% and 84.6%, respectively.Conclusion: We evaluated the utility of FC as a biomarker for assessing ER after GMA and predicting CR in the early phase during GMA in patients with active UC. Our findings will benefit patients with active UC by allowing them to avoid unnecessary invasive procedures and will help establish new strategies for GMA.
Comparison of Statistical and Analytical Hierarchy Process Methods on Flood Susceptibility Mapping: In a Case Study of the Tana Sub-basin in Northwestern Ethiopia
Authors: Wubalem Azemeraw , Tesfaw Gashaw , Dawit Zerihun , Getahun Belete , Mekuria Tamirat , Jothimani Muralitharan 
Published: February 2021

Abstract
The sub-basin of Lake Tana is one of the most flood-prone areas in northwestern Ethiopia, which is affected by flood hazards. Flood susceptibility modeling in this area is essential for hazard reduction purposes. For this, the analytical hierarchy process (AHP), bivariate, and multivariate statistical methods were used. Using an intensive field survey, historical record, and Google Earth Imagery, 1404 flood locations were determined which are classified into 70% training datasets and 30% testing flood datasets using subset in the GIS tool. The statistical relationship between the probability of flood occurrence and eleven flood-driving factors is performed using the GIS tool. Then, the flood susceptibility map of the area is developed by summing all weighted factors using a raster calculator and classified into very low, low, moderate, high, and very high susceptibility classes using the natural breaks method. The results for the area under the curve (AUC) are 99.1% for the frequency ratio model is better than 86.9% using AHP, 81.4% using the logistic regression model, and 78.2% using the information value model. Based on the AUC values, the frequency ratio (FR) model is relatively better followed by the AHP model for regional flood use planning, flood hazard mitigation, and prevention purposes.
Longitudinal Influence of COVID-19-Related Stress on Sexual Compulsivity Symptoms in Chinese Undergraduates
Authors: Deng Jianjun , Li Tsingan , Wang Jiali , Teng Limei 
Published: February 2021

Abstract
Background The coping theory shows that stressful life events are associated with individuals’ psychology/behaviors, and the COVID-19 pandemic is known to have impacted individuals’ physical and mental health. Prior studies revealed that undergraduates have many sexual behavior and emotion disorders, which may be impacted during an isolation period, such as the one brought by COVID-19. However, few studies have explored the longitudinal associations between COVID-19-related stress and sexual compulsivity symptoms (SCS), and the mediating effect of emotions (i.e., depression and anxiety) on this relationship. This longitudinal study aimed to investigate these associations. Methods We employed a cross-lagged design (Time 1, 3,219 participants; Time 2, 2,998 participants) and recruited Chinese undergraduates through an online system to respond to a survey. Results Our results showed that COVID-19-related stress at Time 1 directly influenced SCS at Time 1, and there was an indirect influence via depression and anxiety at Time 1. COVID-19-related stress at Time 1 positively correlated with depression, anxiety, and SCS at Time 2, and the first could directly and positively predict SCS at Time 2. Moreover, albeit depression at Time 2 was negatively linked to SCS at Time 2, anxiety at Time 2 enhanced the effect of COVID-19-related stress on SCS. Conclusions Our findings extend the literature on SCS, showing that the higher the COVID-19-related stress, the higher the SCS, and that this effect was associated with increased anxiety in undergraduates. Thus, compared with depression, anxiety different which anxiety ought to some behavior to reduce individual inner negative emotions.
Tailoring Water Dissociation Energy by Platinum Single-Atom Catalyst Coupled with Transition Metal/metal Oxide Heterostructure for Accelerating Alkaline Hydrogen Evolution Reaction
Authors: Han Changbao , Zhou Kailing , Zhang Qianqian , Liu Jingbing , Yan Hui , Ke Xiaoxing , Wang Zelin , Wang Hao , Wang Changhao , Jin Yuhong 
Published: February 2021

Abstract
High-activity catalysts in alkaline media are compelling for durable hydrogen evolution reaction (HER). Single-atom catalysts (SACs) provide an effective approach to reduce the amount of precious metals meanwhile maintain their catalytic activity. However, the sluggish activity of SACs for water dissociation in alkaline media has extremely hampered advances in highly efficient hydrogen production. Herein, we developed a platinum SAC immobilized NiO/Ni heterostructure (PtSA-NiO/Ni) as an alkaline HER catalyst. It was found that Pt SACs coupled with NiO/Ni heterostructure enable the tunable binding abilities of hydroxyl ions (OH*) and hydrogen (H*), which efficiently tailors the water dissociation energy for accelerating alkaline HER. In particular, the dual active sites consisting of metallic Ni sites and O vacancies modified NiO sites near the interfaces of NiO/Ni in PtSA-NiO/Ni have preferred adsorption affinity for H* and OH* groups, respectively, which efficiently lowers the energy barrier of water dissociation of Volmer step. Moreover, anchoring Pt single atoms at the interfaces of NiO/Ni heterostructure induces more free electrons on Pt sites due to the elevated occupation of the Pt 5d orbital at the Fermi level and reaches a near-zero H binding energy (ΔGH*, 0.07 eV), which further promotes the H* conversion and H2 evolution. Further enhancement of alkaline HER performance was achieved by constructing PtSA-NiO/Ni nanosheets on the Ag nanowires to form a hierarchical three-dimensional (3D) morphology that provides abundant active sites and accessible channels for charge transfer and mass transport. Consequently, the fabricated PtSA-NiO/Ni catalyst displays extremely high alkaline HER performances with a quite high mass activity of 20.6 A mg-1 for Pt at the overpotential of 100 mV, which is 41 times greater than that of the commercial Pt/C catalyst, significantly outperforming the reported catalysts.
Mid-Term Results of Total Hip Arthroplasty Using A Three-Dimensional Porous Titanium Acetabular Cup: An Examination of Micromotion Using Subject-Specific Finite Element Analysis
Authors: Miyagawa Takaki , Matsumoto Kazu , Komura Shingo , Akiyama Haruhiko 
Published: February 2021

Abstract
Background: We investigated the mid-term clinical and radiological results of total hip arthroplasty (THA) using a three-dimensional (3D) porous titanium cup and analysed the micromotion at the interface of the cup using subject-specific finite element (FE) analysis. Methods: We evaluated 73 hips of 65 patients (6 men and 59 women; mean age at the time of surgery 62.2 years, range 45-86 years) who had undergone THA using a 3D porous titanium cup. Clinical evaluation was performed using the Japanese Orthopaedic Association (JOA) hip score system. We assessed the fixation of the acetabular component based on the presence of radiolucent lines and cup migration using anteroposterior radiographs. Subject-specific FE models were constructed from computed tomography data. Results: The JOA score improved from a preoperative mean of 52.2 (range, 23-82) to a mean of 87.8 (range, 71-100) at the final follow-up. None of the patients underwent revisions during the follow-up period. Radiolucent lines were observed in 26 cases (35.6%) and frequently appeared at DeLee and Charnley Zone 3. In the FE analysis, the micromotion at DeLee and Charnley Zone 3 was significantly larger than that at Zones 1 and 2. Furthermore, micromotion was large in the groups in which radiolucent lines appeared at Zone 3. Conclusions: The mid-term clinical outcome of THA using a 3D porous titanium cup was excellent. However, radiolucent lines frequently appeared at DeLee and Charnley Zone 3. FE analysis indicated that micromotion was large at the same site, strongly suggesting that it contributes to the emergence of radiolucent lines. The 3D porous titanium cups are useful in THA, and with improvements focused on micromotion, we anticipate better long-term outcomes.
Controlling COVID-19 Propagation with Quarantine of Influential Nodes
Authors: Chaharborj Sarkhosh S. , Chaharborj Shahriar S. , See Phang Pei 
Published: February 2021

Abstract
We study importance of influential nodes in spreading of epidemic COVID-19 in a complex network. We will show that quarantine of important and influential nodes or consider of health protocols by efficient nodes is very helpful and effective in the controlling of spreading epidemic COVID-19 in a complex network. Therefore, identifying influential nodes in complex networks is the very significant part of dependability analysis, which has been a clue matter in analyzing the structural organization of a network. The important nodes can be considered as a person or as an organization. To find the influential nodes we use the technique for order preference by similarity to ideal solution (TOPSIS) method with new proposed formula to obtain the efficient weights. We use various centrality measures as the multi-attribute of complex network in the TOPSIS method. We define a formula for spreading probability of epidemic disease in a complex network to study the power of infection spreading with quarantine of important nodes. In the following, we use the Susceptible–Infected (SI) model to figure out the performance and efficiency of the proposed methods. The proposed method has been examined for efficiency and practicality using numerical examples.
The effect of environmental concern on renewable energy attitude and usage intention : a case of Turkey
Authors: Arı Erkan , Yilmaz Veysel 
Published: February 2021

Abstract
Energy use-related environmental and social concerns and problems have led to the development of renewable (RE) energy types such as wind, solar, hydraulic, and geothermal energy. Increasing environmental concerns, as well as public awareness and positive attitudes towards sustainable energy types, have played an important role in this development. The present study investigated the effects of the mentioned environmental concerns on the attitudes towards renewable energy and renewable energy usage intention with a proposed structural model. In the first part of the proposed model, the effect of environmental concerns on the awareness and perceived benefits of RE, and in the second part, the effect of awareness and perceived benefits of RE on the RE usage intention was examined. Structural Equation Modelling (SEM) was used to test the model. Regarding the fitness of the model, the chi-square value was calculated as 141.77, and the (χ2/df) value as 2.36. Analysis results demonstrated that one unit increase in environmental concerns would increase awareness of RE by 0.63 and perceived benefits by 0.51 unit. It was also found that awareness of RE would increase the perceived benefits of RE and that especially the increase in awareness positively would affect RE usage intention.
Efficacy of Computed Tomography-assisted Limited Decompression in the Surgical Management of Thoracolumbar Fractures With Neurological Deficit
Authors: Shi Landa , Chou Dean , Wang Yuqiang , Alizada Mirwais , Liu Yilin 
Published: February 2021

Abstract
Objective: to investigate the effect of CT-assisted limited decompression in the management of single segment A3 lumbar burst fracture. Method: A retrospective study of 106 cases with a single-level Magerl type A3 lumbar burst fractures treated with short-segment posterior internal fixation and limited decompression from January 2015 to June 2019 was performed. Patients were divided into two groups: CT-assisted and non-CT-assisted. Perioperative factors, clinical outcomes, postoperative complications, imaging parameters and health-related quality of life (HRQoL) were evaluated. Results: There was no significant difference between the two groups in the kyphosis, anterior vertebral body height loss, posterior vertebral body height loss, operative time, and postoperative complications. The visual analogue score (VAS) and spinal canal encroachment in the CT-assisted group were lower than those in the non-CT-assisted group (P < 0.05). The Japanese Orthopaedic Association score (JOA), the simplified HRQoL scale and American Spinal Injury Association (ASIA) Spinal Cord Injury Grade in the CT-assisted group were higher than those in the non-CT-assisted group (P < 0.05).Conclusion: CT-assisted limited decompression in the treatment of single-segment A3 lumbar burst fracture can achieve better fracture reduction and surgical results, and improve the long-term recovery of neurological function and quality of life of the patients.
Overexpressing PTTG Family Genes Predict Poor Prognosis in KIRC
Authors: Gui Yonghui , Liu Xueni , Wang Chao , Yang Peng 
Published: February 2021

Abstract
Background: Pituitary tumor transforming genes (PTTG1, PTTG2 and PTTG3P) play a key role in the pathogenesis and development of human cancers. Studies show that overexpression of the PTTG genes is associated with tumor progression and migration. However, little is known about the function of the PTTG genes in the prognostic value of renal clear cell carcinoma (KIRC).Methods: the expression and survival data for KIRC patients were mined from ONCOMINE, UALCAN, Human Protein Atlas, TCGAportal, GEPIA2, Metascape，cBioPortal databases and STRING.Results: PTTG1, 2, and 3P mRNA and protein expression was upregulated in KIRC patients compared to normal tissues, and higher expression levels of PTTG family genes were associated with shorter overall survival (OS). what's more, overexpression of the PTTG family genes has been found to correlate with individual cancer stages and pathological tumor grades. In addition, 18% of mutations in the PTTG family genes were associated with short-term survival in patients with KIRCConclusions: we found that a single PTTG genes or PTTG family genes as a whole may be a potential prognostic biomarker for KIRC.
India’s Performance in Controlling Visceral Leishmaniasis as Compared to Brazil Over Past Three Decades: Findings From Global Burden of Disease Study
Authors: DHAMNETIYA DEEPAK , Jha Ravi Prakash , . Shalini , Bhattacharyya Krittika 
Published: February 2021

Abstract
Visceral leishmaniasis (VL) is a neglected tropical disease which contributes to the mortality and morbidity significantly in India and Brazil. This study was planned to compare the trends of incidence, prevalence, death and disability-adjusted life years (DALY) of VL burden in India and Brazil from 1990 to 2019 using Global burden of disease study (GBD) data. The metrics are presented as age-standardized rates per 100,000 inhabitants with their respective uncertainty intervals (95%UI) and relative percentages of change. The decline in the Incidence rate is more in case of India (16.82 cases per 100,000 in 1990 to 0.60cases in 2019) as compared to Brazil (3.12 cases per 100,000 in 1990 to 2.65 cases in 2019). The annualized rate of change in number of prevalent cases for India is -0.95 (95% UI, -0.98 to -0.91) whereas for Brazil it is -0.06 (95% UI, -0.41 to 0.52). The annualized rate of change in number of DALY for India is -0.94 (95% UI, -0.96 to -0.92) whereas for Brazil it is -0.09 (95% UI, -0.25 to 0.28). The annualized rate of change in number of deaths for India is -0.93 (95% UI, -0.95 to -0.92) whereas for Brazil it is increasing i.e. 0.04 (95% UI, -0.12 to 0.51). India achieves significant reduction in the age standardized incidence, prevalence, mortality and DALY of VL as compare to Brazil during the period of 1990 to 2019. A multi-centric study is required to assess bottleneck in the existing strategies of VLSCP in Brazil.
Structural and Thermal Studies of Fluorescein and Rhodamin6G Grafted Diblock Copolymers
Authors: Anbarasan Ramasamy , Meenarathi B. , Parthasarathy V. 
Published: February 2021

Abstract
The ring-opening polymerization (ROP) of tetrahydrofuran (THF) and ε-caprolactone (CL) was performed at 160 oC for 2 hr under N2 ambiance by using two different dyes such as fluorescein (Flur) and rhodamine6G (R6G) as novel initiators. The structure of the dye centered diblock copolymers was concluded by analyzing the NMR spectra. The melt transition temperature and thermal stability of the polymers were concluded by DSC and TGA. The FT-IR spectra concluded the structure of the dye grafted homopolymer and diblock copolymers. The increase in molecular weight (Mw) of the dye-centered diblock copolymer was concluded by the GPC measurement. The conjugation of dye with the polymer backbone was carried out by a single-step method.
Synthesis, Characterization and Electrocatalytic study of Pd supported on CeO2 doped on N, S-rGO towards Hydrogen and Oxygen Evolution
Authors: Woldetinsay Mengistu , Soreta Tesfaye , Palani Krishnamurthy , Maiyalagan Thandavarayan , Olu Femi Emmanuel 
Published: February 2021

Abstract
The sustainable production of hydrogen and oxygen through electrolysis of water requires the development of an efficient electrocatalyst. Herein, we synthesized Pd nanoparticles dispersed on CeO2/N, S-rGO by hydrothermal method followed by chemical reduction of Pd nanoparticles. Electrochemical measurements towards hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) show a high electrocatalytic activity of the catalyst. Among the synthesized electrocatalysts Pd/CeO2/N, S-rGO exhibits lower overpotential (75 mV and 240 mV) at 10 mAcm− 2 and lower Tafel slope value (44 mV dec− 1 and 42 mV dec− 1) for HER and OER, respectively. The chronoamperometric and linear sweep voltammetry (LSV) of the electrocatalyst shows a negligible decrease in the current density for twelve hours and a minor change in the polarization curve after 10,000 cycles, respectively. The high electrocatalytic activity and superior stability of the synthesized electrocatalyst could be attributed to the synergetic effect between Pd nanoparticles and CeO2/N, S-rGO support. This work demonstrates a facile way to develop effective and stable electrocatalysts by exploiting the Pd/Metal oxide interface.
A novel multi-image cryptosystem based on weighted plain images and using combined chaotic maps
Authors: Kari Ahmad Pourjabbar , Navin Ahmad Habibizad , Bidgoli Amir Massoud , Mirnia Mirkamal 
Published: February 2021

Abstract
This paper introduces a new multi-image cryptosystem based on modified Henon map and nonlinear combination of chaotic seed maps. Based on the degree of correlation between the adjacent pixels of the plain image, a unique weight is assigned to the plain image. First, the coordinates of plain images are disrupted by modified Henon map as confusion phase. In the first step of diffusion phase, the pixels content of images are changed separately by XOR operation between confused images and matrices with suitable nonlinear combination of seed maps sequences. These combination of seed maps are selected depending on the weight of plain images as well as bifurcation properties of mentioned chaotic maps. After concatenating the matrices obtained from the first step of diffusion phase, the bitwise XOR operation is applied between newly developed matrix and the other produced matrix from the chaotic sequences of the Logistic-Tent-Sine hybrid system, as second step of diffusion phase. The encrypted image is obtained after applying shift and exchange operations. The results of the implementation using graphs and histograms show that the proposed scheme, compared to some existing methods, can effectively resist common attacks and can be used as a secure method for encrypting digital images.