bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guideline Adherence of β-blocker Initiating Dose and its Consequence in Hospitalized Patients With Heart Failure With Reduced Ejection Fraction
Authors: Zhou Yiling , Zeng Yuping , Wang Si , Li Nan , Wang Miye , Mordi Ify R. , Ren Yan , Zhou Youlian , Zhu Ye , Tian Haoming , Sun Xin , Chen Xiaoping , An Zhenmei , Lang Chim C. , Li Sheyu 
Published: November 2021

Background: We aim to investigate the guideline adherence of β-blocker (BB) initiating dose in Chinese hospitalized patients with heart failure with reduced ejection fraction (HFrEF) and whether the adherence affected the in-hospital outcomes.Methods: This was a retrospective study of patients hospitalized with HFrEF who had initiated BBs during their hospitalization. We defined adherence to clinical practice guidelines as initiating BB with standard dose and non-adherence to guidelines if otherwise, and examined the association between adherence to guidelines and in-hospital BB-related adverse events. Subgroup analyses based on sex, age, coronary heart disease, and hypertension were performed.Results: Among 1,104 patients with HFrEF initiating BBs during hospitalization (median length of hospitalization, 12 days), 304 (27.5%) patients received BB with non-adherent initiating dose. This non-adherence was related to a higher risk (hazard ratio [95% confidence interval]) of BB dose reduction or withdrawal (1.78 [1.42 to 2.22], P &lt; 0.001), but not significantly associated with risks of profound bradycardia, hypotension, cardiogenic shock requiring intravenous inotropes, and severe bronchospasm requiring intravenous steroid during hospitalization.Conclusion: This study identified that over a fourth of patients had received BBs with an initiating dose that was not adherent to guidelines in Chinese hospitalized patients with HFrEF, and this non-adherence was associated with BB dose reduction or withdrawal during hospitalization.
Predictive Analysis of Factors Influencing Depression Status of Nurses in the COVID-19 Pandemic Intensive Care Unit
Authors: Li Jing , Zhang Yanhua , Li Li , Yi Wei , Hao Yiwei , Bi Yongjuan 
Published: November 2021

Purpose: Understand the effects of the COVID-19 pandemic on depression in intensive care unit (ICU) nurses, analyze high-risk factors, and propose appropriate measures to maintain physical and mental health.Methods: A total of 78 nurses in ICU of Beijing Ditan Hospital affiliated with Capital Medical University (Beijing area, COVID-19 patient designated hospital) were investigated with self-rating depression scale (SDS). The Cronbach'sαcoefficient was 0.874, the content validity was 0.853, and the internal consistency was good. General information for the questionnaire: gender, marriage, education, age, title, length of service, ICU years of service, COVID-19 pandemic training, concerns about the COVID-19 pandemic, and current health status.Results: According to the SDS scale score, ICU nurses had a total depression score of 51.36 ± 11.667, and the prevalence rate of depression was 44.9% (35/78). Multi-line regression analysis shows that stress perception, work experience in critical diseases, education and other total scores are risk factors for the occurrence of depression.Conclusion: Work experience in critical illness (β = 9.930, P &lt; 0.001) had a positive predictive effect on the total score of depression, while stress perception (β = −0.884, P &lt; 0.001) and education (β = −6.061, P &lt; 0.001) had a negative predictive effect on the total score of depression, and explained 52.7% variation. These findings point to the need for interventions to address psychological distress and provide the necessary support.
Do Words Matter? Detecting Social Isolation and Loneliness in Older Adults Using Natural Language Processing
Authors: Badal Varsha D. , Nebeker Camille , Shinkawa Kaoru , Yamada Yasunori , Rentscher Kelly E. , Kim Ho-Cheol , Lee Ellen E. 
Published: November 2021

Introduction: Social isolation and loneliness (SI/L) are growing problems with serious health implications for older adults, especially in light of the COVID-19 pandemic. We examined transcripts from semi-structured interviews with 97 older adults (mean age 83 years) to identify linguistic features of SI/L.Methods: Natural Language Processing (NLP) methods were used to identify relevant interview segments (responses to specific questions), extract the type and number of social contacts and linguistic features such as sentiment, parts-of-speech, and syntactic complexity. We examined: (1) associations of NLP-derived assessments of social relationships and linguistic features with validated self-report assessments of social support and loneliness; and (2) important linguistic features for detecting individuals with higher level of SI/L by using machine learning (ML) models.Results: NLP-derived assessments of social relationships were associated with self-reported assessments of social support and loneliness, though these associations were stronger in women than in men. Usage of first-person plural pronouns was negatively associated with loneliness in women and positively associated with emotional support in men. ML analysis using leave-one-out methodology showed good performance (F1 = 0.73, AUC = 0.75, specificity = 0.76, and sensitivity = 0.69) of the binary classification models in detecting individuals with higher level of SI/L. Comparable performance were also observed when classifying social and emotional support measures. Using ML models, we identified several linguistic features (including use of first-person plural pronouns, sentiment, sentence complexity, and sentence similarity) that most strongly predicted scores on scales for loneliness and social support.Discussion: Linguistic data can provide unique insights into SI/L among older adults beyond scale-based assessments, though there are consistent gender differences. Future research studies that incorporate diverse linguistic features as well as other behavioral data-streams may be better able to capture the complexity of social functioning in older adults and identification of target subpopulations for future interventions. Given the novelty, use of NLP should include prospective consideration of bias, fairness, accountability, and related ethical and social implications.
Management of Dental School During the COVID-19 Pandemic: Application of Intervention Mapping
Authors: Heidari Ali , Miresmaeili Amirfarhang , Poormohammadi Ali , Bashirian Saeid , Meschi Marjaneh , Karkehabadi Hamed , Baharmastian Bahareh , Aziziansoroush Omid , Rabienejad Nazli , Shirahmadi Samane 
Published: November 2021

Background: Coronavirus Diesease-2019 (COVID-19) outbreak has led to the suspension of the activities of dental schools. Therefore, reorganizing clinical settings and supporting services as quickly as possible has received much attention to reopen dental schools. The present study aimed to evaluate the applicability of the Intervention Mapping (IM) approach for designing, implementing, and evaluating an intervention program to prevent and control COVID-19 in dental schools.Methods: Following the IM protocol, six steps were completed in the planning and development of an intervention, targeting, and management of Dental School during the COVID-19 pandemic.Results: The information obtained from the needs assessment revealed that the COVID-19 outbreak prevention was associated with the use of personal protective equipment by all target groups, infection control measures taken in the environment, preparation of the environment and equipment, changes in the treatment plan according to the COVID-19 pandemic, changing the admission process of patients, and reduction of attendance of target groups in the school are linked with. In this study, determinant factors affecting the COVID-19 prevention at the individual level were identified based on the Protection Motivation Theory (PMT). In this program, various methods, such as presentation of information, modeling role, and persuasion measures, were utilized and the practical programs included educational films and group discussions implemented.Conclusions: Our findings indicated that intervention in dental environments on the basis of the IM process can develop a comprehensive and structured program in the dental school and hence can reduce the risk of the COVID-19 infection.
Emergency Care Gap in Brazil: Geographical Accessibility as a Proxy of Response Capacity to Tackle COVID-19
Authors: Silva Lincoln Luís , Carvalho Dutra Amanda de , Andrade Luciano de , Iora Pedro Henrique , Rodrigues Ramajo Guilherme Luiz , Peres Gualda Iago Amado , Costa Scheidt João Felipe Hermann , Vasconcelos Maia do Amaral Pedro , Hernandes Rocha Thiago Augusto , Staton Catherine Ann , Nickenig Vissoci João Ricardo , Fressatti Cardoso Rosilene 
Published: November 2021

Background: The new coronavirus disease (COVID-19) has claimed thousands of lives worldwide and disrupted the health system in many countries. As the national emergency care capacity is a crucial part of the COVID-19 response, we evaluated the Brazilian Health Care System response preparedness against the COVID-19 pandemic.Methods: A retrospective and ecological study was performed with data retrieved from the Brazilian Information Technology Department of the Public Health Care System. The numbers of intensive care (ICU) and hospital beds, general or intensivist physicians, nurses, nursing technicians, physiotherapists, and ventilators from each health region were extracted. Beds per health professionals and ventilators per population rates were assessed. A health service accessibility index was created using a two-step floating catchment area (2SFCA). A spatial analysis using Getis-Ord Gi* was performed to identify areas lacking access to high-complexity centers (HCC).Results: As of February 2020, Brazil had 35,682 ICU beds, 426,388 hospital beds, and 65,411 ventilators. In addition, 17,240 new ICU beds were created in June 2020. The South and Southeast regions have the highest rates of professionals and infrastructure to attend patients with COVID-19 compared with the northern region. The north region has the lowest accessibility to ICUs.Conclusions: The Brazilian Health Care System is unevenly distributed across the country. The inequitable distribution of health facilities, equipment, and human resources led to inadequate preparedness to manage the COVID-19 pandemic. In addition, the ineffectiveness of public measures of the municipal and federal administrations aggravated the pandemic in Brazil.
The ReIMAGINE Multimodal Warehouse: Using Artificial Intelligence for Accurate Risk Stratification of Prostate Cancer
Authors: Santaolalla Aida , Hulsen Tim , Davis Jenson , Ahmed Hashim U. , Moore Caroline M. , Punwani Shonit , Attard Gert , McCartan Neil , Emberton Mark , Coolen Anthony , Van Hemelrijck Mieke 
Published: November 2021

Introduction. Prostate cancer (PCa) is the most frequent cancer diagnosis in men worldwide. Our ability to identify those men whose cancer will decrease their lifespan and/or quality of life remains poor. The ReIMAGINE Consortium has been established to improve PCa diagnosis.Materials and methods. MRI will likely become the future cornerstone of the risk-stratification process for men at risk of early prostate cancer. We will, for the first time, be able to combine the underlying molecular changes in PCa with the state-of-the-art imaging. ReIMAGINE Screening invites men for MRI and PSA evaluation. ReIMAGINE Risk includes men at risk of prostate cancer based on MRI, and includes biomarker testing.Results. Baseline clinical information, genomics, blood, urine, fresh prostate tissue samples, digital pathology and radiomics data will be analysed. Data will be de-identified, stored with correlated mpMRI disease endotypes and linked with long term follow-up outcomes in an instance of the Philips Clinical Data Lake, consisting of cloud-based software. The ReIMAGINE platform includes application programming interfaces and a user interface that allows users to browse data, select cohorts, manage users and access rights, query data, and more. Connection to analytics tools such as Python allows statistical and stratification method pipelines to run profiling regression analyses. Discussion. The ReIMAGINE Multimodal Warehouse comprises a unique data source for PCa research, to improve risk stratification for PCa and inform clinical practice. The de-identified dataset characterized by clinical, imaging, genomics and digital pathology PCa patient phenotypes will be a valuable resource for the scientific and medical community.
Increase in Anxiety-Related Out-of-Hours Primary Care Consultations Since COVID-19: An Observational Study Using Routine Data in Flanders
Authors: Van den Broeck Kris , Morreel Stefan , Glazemakers Inge , Verhoeven Veronique , Rens Eva , Philips Hilde 
Published: November 2021

Background: Survey studies suggest that COVID-19 has had a negative impact on the population's mental well-being. Routine registration data allow a more objective way for investigating such associations, complementary to self-report measures. This study investigates the level of out of hours (OOH) consultations for psychological problems since the start of the COVID-19 pandemic in Flanders, Belgium.Methods: The iCAREdata database is a clinical research database with routine data of OOH care, covering a large area in Flanders, Belgium. After defining the first wave and the second wave of COVID-19 in Flanders in time, we compared the number of consultations regarding psychological problems (in general, anxiety-related, depression-related, and sleep-related) between those periods, the period in between these waves, and the period before the start of COVID-19.Results: A significant rise in OOH consultations due to psychological—and more specifically, anxiety-related—problems is observed since the start of the COVID-19 pandemic in Flanders. Elevated levels are observed until the second wave. This finding is in sharp contrast with the general pattern of lower demand for primary healthcare during this period. The majority of these supplementary consultations happened by phone. Consultations regarding depression-related problems did not change over time. Sleep disturbances in the OOH setting were more common after the first wave.Conclusion: Despite some limitations, a large Flemish database with routine data on OOH care shows an increase in the number of consultations regarding psychological problems in general and anxiety-related problems since the start of the COVID-19-pandemic until the second wave.
Decrease in Blood Neutrophil-to-Lymphocyte Ratio Indicates Better Survival After Neoadjuvant Chemotherapy in Patients With Advanced Gastric Cancer
Authors: Liu Ziyi , Liang Yahang , Tang Xiaolong , Qu Hui 
Published: November 2021

Introduction: Gastric cancer is the fifth most commonly diagnosed tumor and is the fourth leading cause of cancer-related mortality, worldwide. Due to the low rate of early diagnosis, approximately two-thirds of patients are first diagnosed at an advanced stage. Neoadjuvant chemotherapy (NAC) is recommended for patients with advanced gastric cancer (AGC). The neutrophil-to-lymphocyte ratio (NLR), a combined inflammatory and immunogenic factor, has been universally used for predicting outcomes in AGC patients. Given that NLR is a dynamic process, in this study, we investigated the value of NLR change for the prediction of chemotherapeutic responses and prognosis in patients with AGC.Methods: We retrospectively enrolled 111 patients with AGC who underwent NAC following curative surgery. Patients were divided into two groups according to the NLR change after chemotherapy into the increased and decreased groups. Outcome measures were overall survival (OS) and disease-free survival (DFS). Univariate was calculated by Kaplan-Meier method. Multivariate analysis was performed using the Cox proportional hazards regression model.Results: Post-chemotherapy, NLR increased in 36 patients and decreased in 75 patients. After a median follow-up time of 19 months, six patients developed local recurrence, 23 developed distant recurrence, and 34 died. Patients with reduced post-chemotherapy NLR showed significantly longer OS (p &lt; 0.001) and DFS (p &lt; 0.001). A decrease in the NLR after NAC was an independent indicator associated with better OS (p &lt; 0.001) and DFS (p &lt; 0.001).Conclusions: In patients with AGC, a decrease in NLR after NAC indicated better survival. NLR change could serve as a robust indicator for the efficiency of NAC and prognostic prediction in patients with AGC.
Taxonomy, Systematics and Evolution of Giant Deer Megaloceros Giganteus (Blumenbach, 1799) (Cervidae, Mammalia) from the Pleistocene of Eurasia
Authors: Croitor Roman 
Published: November 2021

The article presents a preliminary morphological description of the holotype of Megaloceros giganteus (Blumenbach, 1799) that serves for the description of the species. The article proposes a taxonomical and morphological revision of the nominotypical subspecies M. giganteus giganteus and morphological comparison with other subspecies of M. giganteus. The cluster analysis of diagnostic craniodental and antler characters revealed the systematic position and phylogenetic relationships of M. giganteus with other cervid groups. The genus Praedama is regarded as a closely related phylogenetic branch that linked to the direct cursorial forerunner of Megaloceros that evolved in the middle latitudes of Western Siberia and northern Kazakhstan. The genus Dama has a distant relationship with Megaloceros and represents an earlier phylogenetic branch that evolved in the Ponto-Mediterranean area. The article discusses the secondary adaptations of M. giganteus forms to forest and woodland habitats in Europe and general paleobiogeographic features of the Megaloceros lineage.
Potencial antimicrobiano de extratos extracelulares de isolados de actinobactérias e de suas frações orgânicas/ Antimicrobial potential of extracellular extracts of actinobacterial isolates and their organic fractions
Authors: Santos João Soares , Fernandes Marcelo Ferreira , Anjos Érika Cristina Teixeira dos , Fernandes Roberta Pereira Miranda 
Published: November 2021

A utilização de micro-organismos antagonistas e seus metabólitos secundários no controle de fitopatógenos é alvo de grande interesse, já que pode constituir uma alternativa de menor impacto no ambiente em relação aos químicos sintéticos. O cultivo de novos isolados de bactérias antagonistas, além dos gêneros Streptomyces e Bacillus, os quais são fontes da ampla maioria dos antibióticos conhecidos, amplia a possibilidade de descobrir novas moléculas com potencial antimicrobiano. Desse modo, o presente trabalho teve como objetivo avaliar o potencial antimicrobiano de extratos extracelulares de culturas de actinobactérias do solo e de suas frações orgânicas contra os organismos–alvo Xanthomonas campestris 629, Bacillus cereus ATCC14579 e Saccharomyces cerevisiaeV200. Neste estudo foram utilizados cinco isolados de actinobacterias do solo (isolados TC42, TC44, TC70, TC105 e TCX, da Embrapa Tabuleiros Costeiros). Potencial antimicrobiano de extratos extracelulares de isolados de actinobactérias e de suas frações orgânicas/ Antimicrobial potential of extracellular extracts of actinobacterial isolates and their organic fractions
KEPATUHAN IBU HAMIL DALAM KONSUMSI TABLET FE DI WILAYAH KERJA UPTD PUSKESMAS TENAYAN RAYA
Authors: Nadia Fatma , Mianna Rika , Mustolih Ahmad 
Published: November 2021

Compliance pregnant women implement a recommendation health workers to consume tablet fe pregnancy.This behavior can be influenced by knowledge, attitudes and education level. This report aims to review the knowledge, attitudes and levels of compliance pregnant women in consume tablet fe in the work area UPTD Puskesmas Tenayan Raya. This research using design research cross sectional with respondents as much 89 pregnant women .Where taken as random sample of sampling. Data analyzed by test chi square using spss 16,0 with a singnifikan p <0,05. Research results obtained that is no link between knowledge (p value = 0,014 ), attitude ( p value = 0,031 and education ( p value = 0,046 ) of compliance pregnant women in consume fe.Conclusions obtained bahwasannya knowledge, attitudes and education level with links to conduct smoking students, that suggested to the health workers would motivate pregnant women as well as never in providing information about the importance of consume tablet fe against what they contain, these figures mortalitas and morbilitas on the reduced.

Keywords : Knowledge, attitude, education, compliance consumption Fe
Estrategias didácticas para fortalecer el pensamiento creativo en el aula. Un estudio meta-analítico
Authors: Delgado Cecilia 
Published: November 2021

El pensamiento creativo es un talento que poseemos todos los seres humanos, sin embargo, algunos lo ejercitamos más que otros. Desde el punto de vista educativo, este tipo de pensamiento puede ser fortalecido a través de diversos medios. El objetivo de esta investigación fue analizar los conceptos básicos del pensamiento creativo, su importancia y las estrategias didácticas más relevantes utilizadas en el aula para su efectividad. Para ello, se realizó un estudio descriptivo–analítico, revisando diversa literatura científica en revistas indexadas. Se obtuvo información valiosa de 54 artículos científicos, accediendo a diversas fuentes, bases de datos y repositorios como Ebsco, Researchgate, Google scholar, Pro Quest, Scopus, Dialnet y Eric. Los resultados muestran que existen diversas estrategias que se trabajan en el aula que fortalecen y desarrollan el pensamiento creativo. Se concluye que el pensamiento creativo se puede desarrollar desde los primeros niveles de educación básica con actividades motivadoras y significativas para los estudiantes.
Seguimiento del periodo inmediato post-autotrasplante de células progenitoras hematopoyéticas
Authors: Ospino Benjamín , Avila Luz Mábel , Sánchez Natalia Elizabeth 
Published: November 2021

Introducción: el objetivo de este estudio fue describir el comportamiento clínico y de laboratorio presentado en autotrasplante de células progenitoras hematopoyéticas en un grupo de pacientes del Hospital Militar Central en el periodo de enero 2007 a octubre de 2010.
Material y métodos: es un estudio descriptivo retrospectivo a través de la revisión de las historias clínicas de estos pacientes obteniendo la información sobre tiempo de alta pos trasplante, requerimiento transfusional, periodo aplásico (neutropenia absoluta, trombocitopenia severa, anemia severa y presentación de neutropenia febril), número de células madre trasplantadas, fuente y criopreservación o no. Los resultados de las diferentes variables por medir fueron tabulados y almacenados en una base para su posterior análisis descriptivo univariado cualitativo y cuantitativo.
Resultados: todos los pacientes injertaron adecuadamente. El injerto de neutrófilos ocurrió entre 11-23 días, con una media de 14.44; el injerto de plaquetas ocurrió entre 13-25 días, con una media de 16.33, y la duración de la neutropenia absoluta fue de 5-14 días, con una media de 7.28.
Conclusiones: la recuperación de los pacientes fue similar a lo descrito en la literatura internacional. (Acta Med Colomb 2012; 37: 172-176)