bluuebunny/crossref_metadata_2025_split huggingface dataset:
Livro na praça: o espaço não-formal contribuindo para a formação do leitor literário
Authors: Cagliari Susana , Camargo da Silva Veronice 
Published: December 2021

Resumo

Este trabalho tem como objetivo analisar como o espaço não formal pode contribuir para a formação do leitor literário. Os instrumentos de análise foram três projetos de leitura denominados “Livro na Praça”, “Árvore de Livros” e “Piquenique Literário”, destinados a crianças alfabetizadas ou não. Os mesmos aconteceram em espaço não-formal, mais especificamente, no município de Canoas/RS. A metodologia utilizada neste estudo foi uma pesquisa-ação, com análise qualitativa. Nessa perspectiva, neste espaço não-formal, as crianças puderam encontrar livros diversos, fazer suas próprias escolhas, ler ou escutar histórias e, ainda, trocar livros e ideias.

Palavras-chave: Espaços não formais; literature; leitor literário.

Abstract

This work aims to analyze how the non formal space can contribute to the formation of the literary reader. The analysis instruments were three reading projects called “Livro na Praça”, “Árvore de Livros” and Literary Picnic”, aimed at children who are literate or not. The same took place in a non-formal space, more specifically, in the city of Canoas/RS. The methodology used in this study was an action research, with qualitative analysis. From this perspective, in this non-formal space, children could find different books, make their own choices, read or listen to stories, and also exchange books and ideas.

Keywords: Non-formal spaces; literature; literary reader.

Resumen

Este trabajo tiene como objetivo analizar cómo el espacio no formal puede contribuir con la formación del lector literario. Los instrumentos de analisis fueron tres proyectos de lectura denominados “Libro en la plaza”, “Árbol de libros” y “Picnic literario”, dirigidos a niños alfabetizados o no. Dichos proyectos ocurrieron en un espacio no formal, más concretamente, en la ciudad de Canoas/RS. La metodología utilizada en este estudio fue una investigación-acción, con análisis cualitativo. Desde esta perspectiva, en este espacio no formal, los niños pudieron encontrar diferentes libros, tomar sus propias decisiones, leer o escuchar cuentos y también intercambiar libros e ideas.

Palabras clave: Espacios no formales; literatura; lector literario.
Das janelas aos porões: a construção da sensibilidade criadora em cadernos de infância, de Norah Lange
Authors: Azzi Júlia 
Published: December 2021

Este trabalho busca analisar a construção do eu pela escrita memorialística no livro Cadernos de infância, da escritora argentina Norah Lange. Publicada pela primeira vez em 1937, a obra é composta por diversos fragmentos, que narram eventos da infância da personagem-Norah, os quais se combinam para construir essa identidade individual, ligada a um determinado modo de estar no mundo e um olhar pessoal para as coisas, cujo desenvolvimento é o foco principal de sua narração. Pretende-se examinar alguns aspectos constitutivos dessa escrita, tais como a seleção dos episódios e a linguagem marcada pela poeticidade, buscando destrinchar o (auto)retrato que se propõem a criar. Pensa-se este relato memorialístico como uma procura no terreno fértil da infância pelo eu que se tornará o escritor mais tarde, porém não como uma mera busca no passado, mas uma construção que se dá a partir do ato de lembrar no presente, com todas as ressignificações que acompanham esse movimento. Nesse sentido, este artigo busca analisar três questões fundamentais na narrativa, explorando como elas se conectam na busca por uma coerência, mesmo que dispersa, mas necessária para a criação dessa sensibilidade autoral: 1) a linguagem poetizada e conotativa que exprime os acontecimentos, 2) o enfoque dado ao detalhe, ao minúsculo, aos silêncios entre as palavras 3) a escolha temática por episódios relacionados a mortes, doenças, medos e tudo que apresente alguma fragilidade. Como aporte teórico, utilizam-se textos de estudiosos como Aleida Assmann, Jeanne-Marie Gagnebin, Joel Candau, Mikhail Bakhtin e Michael Pollak, entre outros.
PALAVRAS-CHAVE: Cadernos de infância; escrita memorialística; construção identitária.
Therapeutic Potential of Ferulic Acid in Alzheimer's Disease
Authors: Turkez Hasan , Arslan Mehmet Enes , Barboza Joice Nascimento , Kahraman Cigdem Yuce , de Sousa Damiao Pergentino , Mardinoğlu Adil 
Published: December 2021

Abstract:
Alzheimer's Disease (AD) is one of the most important neurodegenerative diseases and it covers 60% of whole dementia cases. AD is a constantly progressing neurodegenerative disease as a result of the production of β-amyloid (Aβ) protein and the accumulation of hyper-phosphorylated Tau protein; it causes breakages in the synaptic bonds and neuronal deaths to a large extent. Millions of people worldwide suffer from AD because there is no definitive drug for disease prevention, treatment or slowdown. Over the last decade, multiple target applications have been developed for AD treatments. These targets include Aβ accumulations, hyper-phosphorylated Tau proteins, mitochondrial dysfunction, and oxidative stress resulting in toxicity. Various natural or semisynthetic antioxidant formulations have been shown to protect brain cells from Aβ induced toxicity and provide promising potentials for AD treatment. Ferulic acid (FA), a high-capacity antioxidant molecule, is naturally synthesized from certain plants. FA has been shown to have different substantial biological properties, such as anticancer, antidiabetic, antimicrobial, anti-inflammatory, hepatoprotective, and cardioprotective actions, etc. Furthermore, FA exerted neuroprotection via preventing Aβ-fibril formation, acting as an anti-inflammatory agent, and inhibiting free radical generation and acetylcholinesterase (AChE) enzyme activity. In this review, we present key biological roles of FA and several FA derivatives in Aβ-induced neurotoxicity, protection against free radical attacks, and enzyme inhibitions and describe them as possible therapeutic agents for the treatment of AD.
Environmental Management System as Sustainable Tools in Water Environmental
Management: A Review
Authors: Shah Kinjal J. , Singh Abhishek V. , Tripathi Satyendra , Hussain Touseef , You Zhaoyang 
Published: December 2021

Background:
The Environmental Management System (EMS) is a unique way to develop an environmental policy with adequate planning, including implementation, operation, checking, and management review.

Objective:
The main stages of the EMS encompass environmental policy, planning, implementation, evaluation, and review.

Method:
A number of environmental standards (ISO 14000), which were drawn up by the international standardization organization, form an essential part of an EMS. This management system introduces environmental management into the day-to-day functions, long-term operations, and resource management frameworks of the organization.

Results:
This overview provides important information about the role of the EMS in water resource management and the scope of the EMS in the water system. This management system is used as an instrument to promote sustainable development in society.

Conclusion:
This paper sheds light on the topic of a sustainable water environment. In addition, some recognized successful EMS systems were reviewed and illustrated. We believe this review provides a guide to a fruitful water environment for successful urbanization planning.
The MicroRNA Days: The COVID-19 Pandemic from the Point of View of Short RNAs
Authors: Izzotti Alberto 
Published: December 2021

Abstract:
Despite their biological simplicity, microRNA-based organisms, such as RNA viruses,
are currently shown to be unexpected threats to mammals, including humans. This situation is exemplified by the COVID-19 pandemic triggered by the spread of SARS-CoV-2.
RNA viruses are older than DNA viruses. Indeed, from an evolutionary standpoint, RNA is an older molecule than DNA. The strength of RNA viruses, compared to DNA viruses, resides in their
simplicity and instability. The instability of RNA viruses, such as human immunodeficiency virus
(HIV) and flu viruses, generates mutants to escape the host’s defense mechanisms. A formidable
combination of lethality and infectivity was recently achieved by SARS-CoV-2. Complex DNAbased defense systems use Toll-like receptors to intercept viral RNA inside a cell. Activation of
Toll-like receptors triggers inflammation and activates lymphocytes and monocytes, causing thromboxane release. In the case of SARS-CoV-2 infection, this process results in cytokine storms and
lung thromboembolism. The ongoing pandemic can be envisioned as a struggle between highly
evolved complex DNA organisms, i.e., humans, and poorly evolved simple RNA organisms, i.e.,
SARS-CoV-2 virus. Quite surprisingly, the complex organism has a serious problem defeating the
simplistic organism. However, humans are finally developing a new effective weapon in fighting
the SARS-CoV-2 virus, paradoxically, RNA-based vaccines. These considerations underscore the
relevance of microRNAs as powerful tools in therapeutic and preventive medicine.
Psychosocial profile of candidates for bariatric surgery and its association with Binge-Eating Disorder
Authors: Coelho Amanda Frazão , Costa Otávia Regina Souza 
Published: December 2021

Objective: To describe the psychosocial profile of candidates for bariatric surgery, verify the prevalence of Binge-Eating Disorder (BED) and analyze the correlation between psychosocial variables in patients with or without BED. Methods: Cross-sectional study. Data collection was based on information from 125 patients, and the Periodic Binge-Eating Scale (BES) was applied by the Psychology section of a general hospital in southern Minas Gerais from July 2019 to March 2020. Candidates were separated into groups with and without BED, and psychosocial variables were correlated with groups. Results: The BED prevalence was 41.6% (52). Most patients were women (101; 80.8%), between 30 and 49 years (68; 54.4%), had a paid job (80; 64%), had completed or incomplete high school (51; 48.8%), reported memories of "remarkable facts" in the child's family environment (78; 62.4%). Anxiety disorders were reported in 37.6% (47) and depressive disorders in 17.6% (22) of the sample. As for weight-loss treatments, 62.4% (78) tried at least three types; 58.4% (73) reported the perception of weight gain in childhood or adolescence. A statistically significant association was observed between BED and a low education (p = 0.009). Conclusion: It was possible to characterize the studied population. It was observed that education can be considered a protective factor for the occurrence of BED.
Prevalence of sarcopenia and associated factors in patients in hemodialysis
Authors: Nunes Camila Ferreira , Carvalho Tuane Rodrigues de , Duarte Ricardo da Silva , Barboza Ylka Anny Couto Oliveira , Lemos Maria Conceição Chaves de , Pinho Claudia Porto Sabino 
Published: December 2021

Objective: To assess the prevalence of sarcopenia and associated factors in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). Methods: This cross-sectional study evaluated patients with CKD undergoing HD from January to October 2016 in two dialysis centers located in Recife, Pernambuco. For the diagnosis of sarcopenia, the criteria proposed by the 2019 European Consensus on Sarcopenia, which advocates low muscle strength as the main criterion, were considered. Demographic, clinical, anthropometric, and behavioral covariates were evaluated. Results: 108 patients were included, with a mean age of 51.4 ± 17.0 years and homogeneous distribution between the sexes.Sarcopenia was present in 38.9% of the population, of which 69% had severe sarcopenia. A higher prevalence of sarcopenia was observed among men (60% vs. 17%; p < 0.001), in those without a partner (48.1% vs. 30.4%; p < 0.045), in smokers (50% vs. 30%; p < 0.034), with low weight (underweight 73.3%, eutrophic 33.9%, overweight 32.4%; p = 0.001) and those with normal albumin levels (47.5% vs. 28.6%; p = 0.045). Conclusion: Approximately one in three nephropathic patients on hemodialysis presented sarcopenia and, among these, most had the severe form of this condition.Uremic sarcopenia was more prevalent in males, in individuals without partners, underweight, in smokers, and among those with normal albumin levels.
Features of acute decompensation of heart failure in patients with type 2 diabetes mellitus with anemia and latent iron deficiency
Authors: Veklich A. S. , Koziolova N. A. 
Published: December 2021

Objective: to assess the contribution of anemia and latent iron deficiency (LID) to the formation of acute decompensation of chronic heart failure (ADHF) in patients with diabetes mellitus (DM) type 2 in history.Materials and methods: a one‑time screening clinical non‑randomized study was conducted. 98 patients with ADHF were examined according to the criteria for inclusion and non‑inclusion, among which 47 (48%) patients suffered from type 2 DM. Among patients with impaired carbohydrate metabolism, 14 (29.8%) patients had an anemic syndrome verified.Results: the prevalence of anemia among hospitalized patients with ADHF against the background of type 2 DM was 29.8%, LID without anemia – 51.5%. Anemic syndrome in patients with ADHF and type 2 DM was represented by iron deficiency anemia in 85.7% and anemia of chronic conditions in 14.3% of cases. In 2/3 of the patients, anemia corresponded to moderate severity. The relative risk (RR) of the development of ADHF against the background of type 2 DM and anemia increases by 2.4 times, in the presence of LID – by 2.9 times. The presence of coronary artery disease, myocardial infarction in history, atrial fibrillation with a heart rate of more than 110 beats per minute, renal dysfunction, high activity of nonspecific inflammation were risk factors for the formation of ADHF in patients with type 2 DM and anemia. The presence of left ventricular hypertrophy in patients with anemia increased the RR of the development of ADHF by 1.8 times, the presence of chronic kidney disease – by 1.7 times, with an increase in the excretion of albumin/protein in the urine >30 mg/g – by 5.7 times, with tubular dysfunction – by 2.4 times, with an increase in aortic stiffness – by 3.5 times.Conclusion: the prevalence of anemia and LID among patients with ADHF and type 2 DM is high. These conditions were risk factors for the development of ADHF and its progression. ADHF in patients with type 2 DM against the background of anemia and LID was characterized by a more severe course, a more pronounced lesion of the target organs.
Features of gene polymorphism in comorbid patients with arterial hypertension and coronary heart disease
Authors: Arutyunyan L. V. , Drobotya N. V. , Pirozhenko A. A. , Kaltukova V. V. 
Published: December 2021

Objective: to assess the prospects of using genetic testing for early detection of patients with arterial hypertension (AH) with a high risk of developing coronary heart disease (IHD).Material and methods: we examined 100 patients with hypertension, who were divided into 2 groups: patients with hypertension without ischemic heart disease (62%, 62 people) and patients with hypertension with ischemic heart disease (38%, 38 people). All patients underwent a standard volume of diagnostic procedures, as well as molecular genetic research. Results: the specificity of the carriage of gene polymorphism was revealed, depending on the presence of isolated AH or AH in combination with IHD in patients. Patients with AH and IHD are characterized by the presence of the CC genotype and the C allele of the ΝΟS3 gene (p = 0,040 and p = 0,035), while the TT genotype of the T‑786C polymorphic marker of the NOS3 gene is characteristic of patients with isolated AH. Conclusion: the study of the genetic aspects of comorbidity is theoretically important for understanding the mechanisms of its formation. From a practical point of view, the opportunity to use modern genetic approaches for early screening of hypertensive patients with a high risk of developing cardiac comorbid pathology is valuable.
Non-motor manifestations in patients with Parkinson's disease
Authors: Goncharova Z. A. , Gelpey M. A. , Mutalieva H. M. 
Published: December 2021

Objective: to study the structure of NMS, their frequency and clinical significance at all stages of PD; to conduct a comparative analysis of the structure of NMS in PD, depending on the stage, form of the disease and gender characteristics of patients.Material and methods: examined 100 patients with PD, 31 patients as the control, and 11 patients as the comparison with Parkinson’s syndrome. The severity of movement disorders was assessed using the Hen and Yar scale. All patients with PD were also clinically assessed according to the UPDRS scale (parts II, III). Cognitive functions were assessed according to the Montreal CI scale (MOCA). The patients’ neuropsychological status was assessed using the Hospital Anxiety and Depression Scale (HADS).Results: vegetative disorders are a frequent manifestation of PD; they differ significantly depending on the gender of the patient and on the stage of the disease. In 20% of patients with PD clinically pronounced depression and severe cognitive impairment were revealed. Conclusion: non‑motor disorders are distinguished by a wide variety of manifestations and combinations, and their structure changes significantly from early to late stages of PD. The presence of NMS is an obligatory sign of PD. Although the structure of non‑motor manifestations of the disease is not specific, attention is drawn to the combination of more than ten different NMS in most patients, which does not occur with natural aging.
Determining the Case Fatality Rate of COVID-19 in Italy: Novel Epidemiological Study
Authors: Yan Mengqing , Kang Wenjun , Guo Zhifeng , Wang Qi , Wang Peizhong Peter , Zhu Yun , Yang Yongli , Wang Wei 
Published: December 2021

Background
COVID-19, which emerged in December 2019, has spread rapidly around the world and has become a serious public health event endangering human life. With regard to COVID-19, there are still many unknowns, such as the exact case fatality rate (CFR).

Objective
The main objective of this study was to explore the value of the discharged CFR (DCFR) to make more accurate forecasts of epidemic trends of COVID-19 in Italy.

Methods
We retrieved the epidemiological data of COVID-19 in Italy published by the John Hopkins Coronavirus Resource Center. We then used the proportion of deaths to discharged cases（including deaths and recovered cases） to calculate the total DCFR (tDCFR), monthly DCFR (mDCFR), and stage DCFR (sDCFR). Furthermore, we analyzed the trend in the mDCFR between January and December 2020 using joinpoint regression analysis, used ArcGIS version 10.7 to visualize the spatial distribution of the epidemic CFR, and assigned different colors to each province based on the CFR or tDCFR.

Results
We calculated the numbers and obtained the new indices of the tDCFR and mDCFR for calculating the fatality rate. The results showed that the tDCFR and mDCFR fluctuated greatly from January to May. They first showed a rapid increase followed by a rapid decline after reaching the peak. The map showed that the provinces with a high tDCFR were Emilia-Romagna, Puglia, and Lombardia. The change trend of the mDCFR over time was divided into the following 2 stages: the first stage (from January to May) and the second stage (from June to December). With regard to worldwide COVID-19 statistics, among 6 selected countries, the United States had the highest tDCFR (4.26%), while the tDCFR of the remaining countries was between 0.98% and 2.72%.

Conclusions
We provide a new perspective for assessing the fatality of COVID-19 in Italy, which can use ever-changing data to calculate a more accurate CFR and scientifically predict the development trend of the epidemic.
Liga Seluler: pergeseran olahraga elektronik ke peranti seluler di Indonesia.
Authors: Jiwandono Haryo P , Purwandi Edeliya Relanika 
Published: December 2021

Dekade 2010-an menjadi awal era perangkat seluler; terdiri dari ponsel pintar dan komputer tablet (Otmazgin, 2008; Richardson, 2011; Jin, 2017), pengembangan agar lebih sesuai dengan permainan digital (Juul, 2009; Richardson, 2011; Jin, 2017). Permainan digital pada perangkat seluler terus mendapatkan popularitas seiring dengan berlalunya dekade; khususnya di Asia Timur (Jin, 2017). Ini didukung oleh budaya teknologi seluler yang kuat di kawasan ini (de Lange, 2015; Jin, 2017) yang menciptakan lingkungan sosioteknik yang subur secara proverbial untuk produksi, distribusi, dan keterlibatan permainan digital seluler di kawasan ini hingga tingkat tinggi (de Lange, 2015; Jin, 2017). Kemudian, sebuah tren baru meningkat di Indonesia karena semakin banyak atlet olahraga elektronik berpartisipasi dalam kompetisi Mobile Legends: Bang Bang yang semakin menguntungkan (Widhana, 2018). Lintasan budaya ini menunjukkan fenomena menarik dari pergeseran perangkat game digital yang kompetitif dari komputer desktop atau laptop dan konsol game digital ke perangkat seluler. Hal tersebut unik karena, bahkan dengan lebih dari 200 juta pelanggan telepon seluler pada awal dasawarsa 2010-an di samping budaya telepon seluler yang kaya (de Lange, 2015), permainan digital seluler yang kompetitif belum pernah mencapai tingkat organisasi dan kepentingan publik yang sama dibandingkan dengan mereka yang dari Mobile Legends: Bang Bang di Indonesia. Selain itu, penelitian sebelumnya tentang game digital mobile (Otmazgin, 2008; Hjorth, 2009; Richardson, 2011; Jin, 2017) belum memberikan diskusi yang signifikan tentang aspek kompetitif game digital seluler.
From Scorching Desert to Tropical Paradise: New Form of Video Game Orientalism in Far Cry 3
Authors: Prawadika Aji Angga 
Published: December 2021

This paper provides an analysis of different form of orientalism found in the third title of the popular Far Cry game series. The open world system offered by Far Cry 3 brings a new nuance in the discourse of orientalism in video games, especially within the context of military shooter game. It provides both opportunities and challenges for developers to build ‘world’ as real as possible for players to explore. This construction process often reflects the orientalism practices shown by game developers in describing Eastern society and culture. Through a variety of activities such as hunting, exploring, sailing, and killing enemy forces, the player acts as a 'western mediator' who intepret the simulated Eastern world as a strange and mysterious territory.