bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metamaterial‐loaded multiband antenna for embedded automotive Internet‐of‐Things communications
Authors: E M Malathy , V Thanikachalam , D Ruby , N Manikandan 
Published: August 2021

SummaryThis study presents the design of a multiband monopole antenna using the metamaterial (MTM) loading technique for embedded automotive Internet‐of‐Things (IoT) communications. The proposed antenna consists of a simple microstrip line monopole loaded with a novel E‐slotted MTM. The unit cell MTM consists of a central transmission line loaded with parasitic patches that are deployed with “E”‐shaped slots. The MTM is symmetrically loaded to either side of the monopole antenna to achieve miniaturization through frequency reduction and to realize multiple resonances. The proposed monopole antenna has a footprint of 10 × 30 mm2and operates at 2.45, 3.3, and 3.8 GHz suitable for Industrial Scientific and Medical applications (ISM), Wireless Fidelity (WiFi), and Worldwide Interoperability for Microwave Access (WiMAX) applications that are exploited in IoT communications. The prototype antenna is fabricated, and the simulation results are validated using experimental measurements. The prototype antenna offers the measured impedance bandwidth of 6%, 7%, and 10% at the said frequencies. The measured gain of the antenna is greater than 3.2 dBi, and the simulated efficiency is close to 86% throughout the operating bandwidth. The performance of the proposed antenna in the vicinity of the vehicle is tested, and the results are presented.
Solitary fibrous tumor of the pancreas clinically mimicking a pancreatic neuroendocrine tumor: Cytologic pitfalls when a transgastric approach is utilized
Authors: Marotti Jonathan D. , Liu Xiaoying , Jamot Sehrish , Gardner Timothy B. , Gordon Stuart R. , Kerr Darcy A. 
Published: August 2021

AbstractSolitary fibrous tumor (SFT) involving the pancreas is a rare entity often diagnosed on surgical specimens rather than cytology samples. Pancreatic SFT frequently mimics pancreatic neuroendocrine tumor radiographically, which presents unique challenges to the cytologist during rapid on‐site assessment. We describe a case of pancreatic SFT with a focus on the cytologic pitfalls that might be encountered during transgastric procedures. We also review the available cytologic findings of prior pancreatic SFT cases.
Targeted deletion of Atoh8 results in severe hearing loss in mice
Authors: Tang Qi , Xie Meng‐Yao , Zhang Yong‐Li , Xue Ruo‐Yan , Zhu Xiao‐Hui , Yang Hua 
Published: August 2021

SummaryAtoh8, also named Math6, is a bHLH gene reported to have important functions in the developing nervous system, pancreas and kidney. However, the expression pattern and function of Atoh8 in the inner ear are still unclear. To study the function of Atoh8 in the developing mouse inner ear, we performed targeted deletion of Atoh8 by intercrossing Atoh8lacZ/+ mice. We studied the expression pattern of Atoh8 in the inner ear and found interesting results that Atoh8‐null (Atoh8lacZ/lacZ) mice were viable but smaller than their littermates and they were severely hearing impaired, which was confirmed by hearing tests (ABR, DPOAE). We collected 129 viable newborns from 18 litters by crossing Atoh8lacZ/+ mice and found that the distributions of Atoh8lacZ/+, Atoh8lacZ/lacZ and wild type were very close to their expected Mendelian ratio by χ2 testing. However, no remarkable morphological changes in cochleae in mutant mice were detected under plastic sectioning and electron microscopy. No remarkable differences in the expression of Myosin6, Prestin, TrkC, GAD65, Tuj1, or Calretinin were detected between the mutant mice and the control mice. These findings indicate that Atoh8 plays an important role in the development of normal hearing, while further studies are required to elucidate its exact function in hearing.
A Proline and 4‐Hydroxyproline Based Approach to Enantiopure Pyrrolidin‐2‐yl‐Substituted Pyridine and Pyrimidine Derivatives
Authors: Brennecke Benjamin , Castello Micó Alicia , Selter Lars , Accorsi Matteo , Zimmer Reinhold , Reissig Hans‐Ulrich 
Published: August 2021

AbstractThe optimized coupling of N‐protected (S)‐proline and (2S,4R)‐4‐hydroxyproline derivatives with (Z)‐4‐aminopent‐3‐en‐2‐one provided the expected β‐ketoenamides in good to excellent yields. The subsequent intramolecular cyclizations afforded enantiopure pyridin‐4‐one derivatives with pyrrolidin‐2‐yl substituents. The nonaflates generated from these intermediates were excellent precursors for typical palladium‐catalyzed coupling reactions. Oxidation with m‐chloroperbenzoic acid gave pyrrolidine N‐oxides whose subsequent reactions were investigated. The condensation of β‐ketoenamides with hydroxylamine hydrochloride furnished the corresponding enantiopure pyrimidine N‐oxides in good yields. The subsequent Boekelheide rearrangement provided hydroxymethyl‐substituted pyrimidine derivatives together with minor components. Overall, this study nicely demonstrates the potential of (S)‐proline‐ or (2S,4R)‐4‐hydroxyproline‐derived β‐ketoenamides to approach a library of novel chiral pool‐derived enantiopure functionalized pyridine and pyrimidine derivatives.
Development of a moving model rig with a large Reynolds number and measurement of aerodynamic drag
Authors: Yang Qiansuo 
Published: August 2021

AbstractThe principles and techniques for developing a moving model rig (MMR) driven by compressed air were introduced for moving model tests at large Reynolds numbers (). A corresponding methodology for the accurate measurement of the aerodynamic drag was developed. The main functions of the MMR included the acceleration of the trailer and the model, the deceleration of the trailer, and the deceleration of the model. The acceleration power was provided by the expansion of the compressed air in a pipe, and the deceleration of the model came from the relative motion between the permanent magnet and the static iron deceleration floor. The braking of the trailer was supplied by either a magnetic damping force or the compression of the air in the pipeline by the trailer piston. The free motion of the model in the test section followed the Davis equation. Based on this, a method for the measurement of the model aerodynamic drag using the measured acceleration data was proposed and experimentally demonstrated in an MMR developed in this work.
Application of zirconium modified layered double hydroxide and calcination product for adsorptive removal of phosphate from aqueous solution
Authors: Motandi Mave Koko , Zhang Zhaoran , Inkoua Stelgen , Yan Liangguo 
Published: August 2021

AbstractLayered double hydroxides (LDHs) have been designed and applied in environmental remediation based on their tunable physical structure and excellent chemical performance. To investigate the adsorption behavior of aqueous phosphate by the LDH‐based composite, zirconium‐modified Mg‐Al‐LDH (Zr‐LDH) was synthesized by the coprecipitation method, and subsequently calcined to obtain a layered double oxide (Zr‐LDO). Scanning electron microscopy, X‐ray diffraction, and Fourier transform infrared spectroscopy were used to describe the micromorphology, crystal structure, and functional groups of Zr‐LDH and Zr‐LDO, respectively. The as‐synthesized materials were subsequently selected as adsorbents to adsorb aqueous phosphate using batch equilibrium methods. The results showed that Zr‐LDH and Zr‐LDO can rapidly and efficiently reduce the phosphate concentration. The optimum dosage of LDH, Zr‐LDH, and Zr‐LDO was selected as 0.05 g. The adsorption efficiencies of Zr‐LDH and Zr‐LDO for phosphate were above 95% during the first 10 min. The experimental data agreed well with the pseudo‐second‐order equation, and the Langmuir and Freundlich equations. The maximum adsorption capacities of Zr‐LDH and Zr‐LDO were 99.35 and 80.33 mg/g, respectively. Moreover, the reaction process was spontaneous and endothermic. Zr‐LDH and Zr‐LDO have good reusability and selectivity, and are promising materials for aqueous phosphate removal. This work confirms that Zr‐LDH and Zr‐LDO can be selected as favorable sorbents to remove phosphate from wastewater.
From mouse to mouse‐ear cress: Nanomaterials as vehicles in plant biotechnology
Authors: Xia Xue , Shi Bingyang , Wang Lei , Liu Yang , Zou Yan , Zhou Yun , Chen Yu , Zheng Meng , Zhu Yingfang , Duan Jingjing , Guo Siyi , Jang Ho Won , Miao Yuchen , Fan Kelong , Bai Feng , Tao Wei , Zhao Yong , Yan Qingyu , Cheng Gang , Liu Huiyu , Jiao Yan , Liu Shanhu , Huang Yuanyu , Ling Daishun , Kang Wenyi , Xue Xue , Cui Daxiang , Huang Yongwei , Cui Zongqiang , Sun Xun , Qian Zhiyong , Gu Zhen , Han Gang , Yang Zhimou , Leong David Tai , Wu Aiguo , Liu Gang , Qu Xiaogang , Shen Youqing , Wang Qiangbin , Lowry Gregory V. , Wang Ertao , Liang Xing‐Jie , Gardea‐Torresdey Jorge , Chen Guoping , Parak Wolfgang J. , Weiss Paul S. , Zhang Lixin , Stenzel Martina M. , Fan Chunhai , Bush Ashley I. , Zhang Gaiping , Grof Christopher P. L. , Wang Xuelu , Galbraith David W. , Tang Ben Zhong , Offler Christina E. , Patrick John W. , Song Chun‐Peng 
Published: August 2021

AbstractBiological applications of nanomaterials as delivery carriers have been embedded in traditional biomedical research for decades. Despite lagging behind, recent significant breakthroughs in the use of nanocarriers as tools for plant biotechnology have created great interest. In this Perspective, we review the outstanding recent works in nanocarrier‐mediated plant transformation and its agricultural applications. We analyze the chemical and physical properties of nanocarriers determining their uptake efficiency and transport throughout the plant body.
More Pronounced Hypercoagulable State and Hypofibrinolysis in Patients With Cirrhosis With Versus Without HCC
Authors: Zanetto Alberto , Campello Elena , Bulato Cristiana , Gavasso Sabrina , Saggiorato Graziella , Shalaby Sarah , Spiezia Luca , Cillo Umberto , Farinati Fabio , Russo Francesco Paolo , Burra Patrizia , Senzolo Marco , Simioni Paolo 
Published: August 2021

In patients with cirrhosis, particularly those with hepatocellular carcinoma (HCC), hypercoagulability may be associated with purported increased risks of portal vein thrombosis and cirrhosis progression. In this study, we extensively investigated hemostatic alterations potentially responsible for the thrombotic tendency in HCC, and evaluated whether such alterations were predictive of hepatic decompensation. Patients with cirrhosis at all stages were prospectively recruited and underwent an extensive hemostatic assessment, including all procoagulant factors and inhibitors, thrombin generation with and without thrombomodulin (TG), profibrinolytic and antifibrinolytic factors, and plasmin‐antiplasmin complex. In study part 1 (case control), we compared alterations of coagulation and fibrinolysis in patients with cirrhosis with versus without HCC. In study part 2 (prospective), the subgroup of patients with decompensated cirrhosis was followed for development of further decompensation, and predictors of outcome were assessed by multivariate analysis. One‐hundred patients were recruited (50 each with and without HCC). Severity of cirrhosis was comparable between groups. Median HCC volume was 9 cm3 (range: 5‐16). Compared with controls, patients with HCC demonstrated a significantly more prothrombotic hemostatic profile due to increased TG and reduced activation of fibrinolysis, independent of cirrhosis stage. During a median follow‐up of 175 days, 20 patients with decompensated cirrhosis developed further episodes of decompensation that were predicted by low FVII and high plasminogen activator inhibitor‐1 levels, independent of Model for End‐Stage Liver Disease score. Conclusion: Patients with cirrhosis with HCC have profound hyper‐coagulable changes that can account for their increased thrombotic tendency. In contrast, hypercoagulability in patients with decompensated cirrhosis is more likely a consequence of chronic liver disease rather than a driver for cirrhosis progression.
Evaluating suspended sediment and turbidity reduction projects in a glacially conditioned catchment through dynamic regression and fluvial process‐based modelling
Authors: Wang Kezhen , Davis Dany , Steinschneider Scott 
Published: August 2021

AbstractElevated turbidity (Tn) and suspended sediment concentrations (SSC) during and following flood events can degrade water supply quality and aquatic ecosystem integrity. Streams draining glacially conditioned mountainous terrain, such as those in the Catskill Mountains of New York State, are particularly susceptible to high levels of Tn and SSC sourced from erosional contact with glacial‐related sediment. This study forwards a novel approach to evaluate the effectiveness of stream restoration best management practices (BMPs) meant to reduce stream Tn and SSC, and demonstrates the approach within the Stony Clove sub‐basin of the Catskills, a water supply source for New York City. The proposed approach is designed to isolate BMP effects from natural trends in Tn and SSC caused by trends in discharge and shifts in average Tn or SSC per unit discharge (Q) following large flood events. We develop Dynamic Linear Models (DLMs) to quantify how Tn‐Q and SSC‐Q relationships change over time at monitoring stations upstream and downstream of BMPs within the Stony Clove and in three other sub‐basins without BMPs, providing observational evidence of BMP effectiveness. A process‐based model, the River Erosion Model, is then developed to simulate natural, hydrology‐driven SSC‐Q dynamics in the Stony Clove sub‐basin (absent of BMP effects). We use DLMs to compare the modelled and observed SSC‐Q dynamics and isolate the influence of the BMPs. Results suggest that observed reductions in SSC and Tn in the Stony Clove sub‐basin have been driven by a combination of declining streamflow and the installed BMPs, confirming the utility of the BMPs for the monitored hydrologic conditions.
Implementing an insolvency framework for micro and small firms
Authors: Gurrea‐Martínez Aurelio 
Published: August 2021

AbstractMicro‐, small‐, and medium‐sized enterprises (MSMEs) represent the vast majority of businesses in most countries around the world. Despite the economic relevance of these firms, most insolvency jurisdictions do not provide adequate responses to MSMEs. Moreover, with a few exceptions, the academic literature on insolvency law has not traditionally focused on the treatment of MSMEs in insolvency. This article seeks to contribute to the debate by exploring the primary features and problems of MSMEs in insolvency as well as the weaknesses of the ordinary insolvency framework to deal with MSMEs. It also provides a general overview of the primary reforms and policy recommendations taking place around the world to deal with MSMEs in insolvency. The article concludes by suggesting several strategies to design an efficient insolvency framework for MSMEs.
Computational Chemistry in the Undergraduate Classroom – Pedagogical Considerations and Teaching Challenges
Authors: Tuvi‐Arad Inbal 
Published: August 2021

AbstractThe interdisciplinary field of computational chemistry links many facets of chemistry and provides unique insights into structure, mechanisms, dynamics, and the interplay between them. Various approaches were proposed for integrating computational chemistry in the undergraduate classroom, all highlight the benefits of including it in the chemistry curriculum. This study focuses on the desirable learning outcomes, and defines a structural framework of computational chemistry literacy. Based on this approach analysis of the pedagogical approach of selected studies that implemented computational chemistry in undergraduate chemistry classrooms is presented. Three models for including computational chemistry in the undergraduate program were uncovered in this analysis: the specialized course model, the augmented course model, and the islands of computations model. These models are discussed along with teaching and learning challenges as well as routes to bypass them.
AC016405.3 functions as an oncogenic long non‐coding RNA by regulating ERBB3 via sponging miR‐22‐3p in breast cancer
Authors: Wei Min , Wang Jie , He Qi , Liu Lei , Wang Zhiwei 
Published: August 2021

AbstractBackgroundIncreasing studies reported that long non‐coding RNAs are involved in regulating breast cancer (BRCA) progression. However, the specific roles and mechanisms of lncRNAs in BRCA remain largely unknown. Here, we sought to explore the functions and mechanisms of AC016405.3 in BRCA progression.MethodsBioinformatic analysis for AC016405.3, miR‐22‐3p, and ERBB3 were performed on starBase. The expressions of AC016405.3, miR‐22‐3p, and ERBB3 were examined by RT‐qPCR. The functions of AC016405.3 on the proliferation, migration, and invasion of cells were evaluated by conducting CCK‐8, colony formation, wound‐healing, and Transwell assays. The subcellular distribution of AC016405.3 in BRCA cells was identified by performing fluorescence in situ hybridization (FISH) and subcellular fractionation techniques. Dual‐luciferase assay was applied to validate the interactions of miR‐22‐3p with AC016405.3 or ERBB3. The interaction between ERBB3 and miR‐22‐3p was also tested by Anti‐Ago2 RNA immunoprecipitation (RIP) assay.ResultsThe results showed that AC016405.3 is highly expressed in BRCA tissues as well as cells and positively correlated with poor prognosis in BRCA patients. Silencing AC016405.3 obviously repressed the malignant behaviors of BRCA cells. Mechanistically, AC016405.3 functioned as a competing endogenous RNA (ceRNA) for miR‐22‐3p in the cytoplasm and sponged miR‐22‐3p to release its suppression of ERBB3. Rescue experiments revealed that the suppression role induced by AC016405.3 depletion on malignant behaviors of BRCA cells could be obviously counter by inhibiting miR‐22‐3p or overexpressing ERBB3.ConclusionAC016405.3 promotes BRCA progression by the derepression of ERBB3 via sponging miR‐22‐3p, which may represent a potential target for BRCA treatment.
The clinical value of high fluorescent lymphocytes and smudge cells in the diagnosis of infectious mononucleosis
Authors: Huang Tao , Yang Shuo , He Yufeng , Li Qiang , Cui Liyan 
Published: August 2021

AbstractBackgroundThe diagnostic value of high fluorescent lymphocytes (HFLC) and smudge cells in diseases like sepsis has been confirmed. In this study, we explore the diagnostic value of HFLC and smudge cells for infectious mononucleosis (IM).MethodsSixty‐two IM patients, 67 healthy controls, 84 patients with upper respiratory tract virus infection, and 35 patients with malignant lymphoid diseases were enrolled. The complete blood counts and leukocyte differential counts are tested, and the smudge cells were manually counted.ResultsThe value of HFLC% and smudge cells of the IM group were significantly higher than those of healthy controls and disease controls (p < 0.05), and the HFLC% value of IM patients was positively correlated with the number of reactive lymphocytes (r = 0.265). When the cutoff value of HFLC% was 0.4%, and the diagnostic value of IM was high (AUC = 0.995). When the smudge cells >2/100 nucleated cells, it can show better (AUC = 1.000). When the cutoff value of the HFLC% was 1.2%, it can effectively distinguish IM patients from upper respiratory tract virus infection patients (AUC = 0.934); when smudge cells >16/100 nucleated cells, it also has high differential diagnosis value (AUC = 0.913). In addition, the AUC of the combination HFLC% and smudge cells for the differential diagnosis can be increased to 0.968. The performance value of single HFLC% (AUC = 0.942) for distinguishing IM from malignant lymphoid diseases was better than smudge cells and combine index with the cutoff value of 0.4%.ConclusionHFLC% and smudge cells can be used as effective indicators in the early diagnosis and differential diagnosis of IM.
The importance of first trimester screening of cranial posterior fossa in predicting posterior fossa malformations which may be identified in the following weeks of gestation
Authors: Eric Ozdemir Mucize , Demirci Oya , Ayvaci Tasan Habibe , Ohanoglu Karolin , Akalin Munip 
Published: August 2021

AbstractPurposeWe aimed to investigate the value of posterior fossa ultrasonography measurements in predicting fetal posterior fossa anomaly at 11–14 weeks of gestation.MethodsThe study was performed at Zeynep Kamil Women and Children's Diseases Training and Research Hospital. Measurements were made in two groups: the control group consisted of 328 fetuses with normal postnatal outcome and the study group consisted of 22 fetuses with enlarged 4th ventricle. In the study group, we questioned the value of intracranial translucency (IT) and brainstem (BS) measurements and the BS/brainstem‐to‐occipital bone (BSOB) ratio in order to predict possible posterior fossa anomalies that may be identified in advanced gestational weeks. The differences of ultrasonographic measurements between groups with p < 0.05 were considered statistically significant.ResultsIT value, BSOB value, and BS/BSOB ratio were determined as ultrasonographic variables in predicting normal development of the fetal posterior fossa, with cutoff values of 2.7, 5.1, and 0.3. Negative predictive values of these three measurements for posterior fossa abnormalities were 100%. There was no statistically significant difference between the three variables for other diagnostic accuracy values (specifities and positive predictive values) (p > 0.05).ConclusionIT, BSOB, and BS/BSOB ratio can be used as ultrasonographic markers to predict the normal development of the fetal posterior fossa.
Genetic counseling clinical documentation: Practice Resource of the National Society of Genetic Counselors
Authors: Hunt Brendish Katherine , Patel Devanshi , Yu Kristen , Alexander Chelsea K. , Lemons Jennifer , Gunter Andrew , Carmany Erin P. 
Published: August 2021

AbstractClinical documentation is an important extension of a genetic counseling encounter. The traditional types of clinical documentation include the clinical visit note (including follow‐up visit note), letter to the referring physician, letter to the patient, and result summary to the patient and referring physician. Increasing patient volumes, new genetic counseling service delivery models, transition to electronic medical records (EMR), new specialty clinics in genetics, and advances in genetic testing technologies challenge the practice of writing multiple types of clinical documents. This practice resource (PR) seeks to provide best practices for U.S.‐based genetic counselors to write efficient and comprehensive clinical documentation using a hybrid clinical document designed to facilitate communication between individual providers, providers, and patients/families, and providers and payers. The content of the hybrid clinical documentation will vary by genetic specialty but may include a summary of genetic services evaluation, genetic testing options and eligibility information, genetic test results, potential risks for genetic conditions, implications for family members, and medical management recommendations. An outline of a general hybrid document along with examples of hybrid clinic notes for three types of genetic counseling specialties is included in this document.