bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Machine Learning Classifier for Detection of Physical Activity Types and Postures During Free-Living
Authors: Bach Kerstin , Kongsvold Atle , Bårdstu Hilde , Bardal Ellen Marie , Kjærnli Håkon S. , Herland Sverre , Logacjov Aleksej , Mork Paul Jarle 
Published: December 2021

Introduction:Accelerometer-based measurements of physical activity types are commonly used to replace self-reports. To advance the field, it is desirable that such measurements allow accurate detection of key daily physical activity types. This study aimed to evaluate the performance of a machine learning classifier for detecting sitting, standing, lying, walking, running, and cycling based on a dual versus single accelerometer setups during free-living.Methods:Twenty-two adults (mean age [SD, range] 38.7 [14.4, 25–68] years) were wearing two Axivity AX3 accelerometers positioned on the low back and thigh along with a GoPro camera positioned on the chest to record lower body movements during free-living. The labeled videos were used as ground truth for training an eXtreme Gradient Boosting classifier using window lengths of 1, 3, and 5 s. Performance of the classifier was evaluated using leave-one-out cross-validation.Results:Total recording time was ∼38 hr. Based on 5-s windowing, the overall accuracy was 96% for the dual accelerometer setup and 93% and 84% for the single thigh and back accelerometer setups, respectively. The decreased accuracy for the single accelerometer setup was due to a poor precision in detecting lying based on the thigh accelerometer recording (77%) and standing based on the back accelerometer recording (64%).Conclusion:Key daily physical activity types can be accurately detected during free-living based on dual accelerometer recording, using an eXtreme Gradient Boosting classifier. The overall accuracy decreases marginally when predictions are based on single thigh accelerometer recording, but detection of lying is poor.
World Health Organization and knowledge translation in maternal, newborn, child and adolescent health and nutrition
Authors:   STAGE (Strategic Technical Advisory Group of Experts), Duke Trevor , AlBuhairan Fadia S , Agarwal Koki , Arora Narendra K , Arulkumaran Sabaratnam , Bhutta Zulfiqar A , Binka Fred , Castro Arachu , Claeson Mariam , Dao Blami , Darmstadt Gary L , English Mike , Jardali Fadi , Merson Michael , Ferrand Rashida A , Golden Alma , Golden Michael H , Homer Caroline , Jehan Fyezah , Kabiru Caroline W , Kirkwood Betty , Lawn Joy E , Li Song , Patton George C , Ruel Marie , Sandall Jane , Sachdev Harshpal Singh , Tomlinson Mark , Waiswa Peter , Walker Dilys , Zlotkin Stanley 
Published: December 2021

The World Health Organization (WHO) has a mandate to promote maternal and child health and welfare through support to governments in the form of technical assistance, standards, epidemiological and statistical services, promoting teaching and training of healthcare professionals and providing direct aid in emergencies. The Strategic and Technical Advisory Group of Experts (STAGE) for maternal, newborn, child and adolescent health and nutrition (MNCAHN) was established in 2020 to advise the Director-General of WHO on issues relating to MNCAHN. STAGE comprises individuals from multiple low-income and middle-income and high-income countries, has representatives from many professional disciplines and with diverse experience and interests.Progress in MNCAHN requires improvements in quality of services, equity of access and the evolution of services as technical guidance, community needs and epidemiology changes. Knowledge translation of WHO guidance and other guidelines is an important part of this. Countries need effective and responsive structures for adaptation and implementation of evidence-based interventions, strategies to improve guideline uptake, education and training and mechanisms to monitor quality and safety. This paper summarises STAGE’s recommendations on how to improve knowledge translation in MNCAHN. They include support for national and regional technical advisory groups and subnational committees that coordinate maternal and child health; support for national plans for MNCAHN and their implementation and monitoring; the production of a small number of consolidated MNCAHN guidelines to promote integrated and holistic care; education and quality improvement strategies to support guidelines uptake; monitoring of gaps in knowledge translation and operational research in MNCAHN.
Eosinophilic fasciitis (Shulman disease) with clinical, imaging and pathological correlation
Authors: Primitivo Ana , Madeira Nathalie , Lopez Dolores , Afonso Diana 
Published: December 2021

Eosinophilic fasciitis (EF) is a rare subacute fibrosing disorder of unknown aetiology, characterised by thickening of the muscular fascia and subcutaneous tissue, leading to swelling of limbs and trunk and sparing fingers and toes. Eosinophilic infiltration and degranulation may prompt tissue damage and consequent fibrosis due to the accumulation of collagen and extracellular matrix proteins. MRI is the best imaging modality for diagnosis, depicting fascial thickening and enhancement. MRI may also have a significant role in excluding alternative diagnosis and guiding the skin–muscle biopsy.We report a case of EF with clinical and pathological correlation, highlighting the diagnostic value of MRI for early diagnosis and further treatment.
Improving maternal and child health in Pakistan: a programme evaluation using a difference in difference analysis
Authors: Malik Muhammad Ashar , Rohm Lara Riedige , van Baal Pieter , van Doorslaer Eddy van Doorslaer 
Published: December 2021

IntroductionPakistan is a country with high maternal and infant mortality. Several large foreign funded projects were targeted at improving maternal, neonatal and child health. The Norway-Pakistan Partnership Initiative (NPPI) was one of these projects. This study aims to evaluate whether NPPI was successful in improving access and use of skilled maternal healthcare.MethodsWe used data from three rounds (2009–2010, 2011–2012 and 2013–2014) of the Pakistan Social and Living Standards Measurement Survey (PSLM). A difference-in-difference regression framework was used to estimate the effectiveness of NPPI and its different programme components with respect to maternal healthcare seeking behaviour of pregnant women. Various parts of the PSLM were combined to examine the healthcare seeking behaviour response of pregnant women to exposure to NPPI.ResultsTrends in maternal care seeking behaviour of pregnant women were similar in districts exposed to NPPI and control districts. Consequently, only a weak and insignificant impact of NPPI on maternal care seeking behaviour was found. However, women in districts which used vouchers or which implemented contracting were more likely to seek skilled assistance with their delivery.ConclusionWe conclude that the objective to improve access to and use of skilled care was not achieved by NPPI. The small effects identified for vouchers and contracts on skilled birth attendance hold some promise for further experimentation.
Phase 2 trial design of BMS-986278, a lysophosphatidic acid receptor 1 (LPA1) antagonist, in patients with idiopathic pulmonary fibrosis (IPF) or progressive fibrotic interstitial lung disease (PF-ILD)
Authors: Corte Tamera J , Lancaster Lisa , Swigris Jeffrey J , Maher Toby M , Goldin Jonathan G , Palmer Scott M , Suda Takafumi , Ogura Takashi , Minnich Anne , Zhan Xiaojiang , Tirucherai Giridhar S , Elpers Brandon , Xiao Hong , Watanabe Hideaki , Smith R Adam , Charles Edgar D , Fischer Aryeh 
Published: December 2021

IntroductionIdiopathic pulmonary fibrosis (IPF) and non-IPF, progressive fibrotic interstitial lung diseases (PF-ILD), are associated with a progressive loss of lung function and a poor prognosis. Treatment with antifibrotic agents can slow, but not halt, disease progression, and treatment discontinuation because of adverse events is common. Fibrotic diseases such as these can be mediated by lysophosphatidic acid (LPA), which signals via six LPA receptors (LPA1–6). Signalling via LPA1appears to be fundamental in the pathogenesis of fibrotic diseases. BMS-986278, a second-generation LPA1antagonist, is currently in phase 2 development as a therapy for IPF and PF-ILD.Methods and analysisThis phase 2, randomised, double-blind, placebo-controlled, parallel-group, international trial will include adults with IPF or PF-ILD. The trial will consist of a 42-day screening period, a 26-week placebo-controlled treatment period, an optional 26-week active-treatment extension period, and a 28-day post-treatment follow-up. Patients in both the IPF (n=240) and PF-ILD (n=120) cohorts will be randomised 1:1:1 to receive 30 mg or 60 mg BMS-986278, or placebo, administered orally two times per day for 26 weeks in the placebo-controlled treatment period. The primary endpoint is rate of change in per cent predicted forced vital capacity from baseline to week 26 in the IPF cohort.Ethics and disseminationThis study will be conducted in accordance with Good Clinical Practice guidelines, Declaration of Helsinki principles, and local ethical and legal requirements. Results will be reported in a peer-reviewed publication.Trial registration numberNCT04308681.
Mental health and behavioural factors involved in road traffic crashes by young adults: analysis of the Raine Study
Authors: Tait Robert , Ivers Rebecca , Marino Jennifer L , Doherty Dorota , Graham Petra L , Cunich Michelle , Sanci Lena , Steinbeck Katharine , Straker Leon , Skinner S Rachel 
Published: December 2021

BackgroundRoad traffic crashes (RTC) are a leading cause of mortality and morbidity in young people. Severe mental health and behavioural conditions increase the likelihood of RTC, as do a range of driving-risk activities.MethodWe used data from the Raine Study, a prebirth cohort from Perth, Australia, to assess the relationship between measures of common mental health or behavioural conditions (Child Behavior Checklist Internalising and Externalising scores) at age 17 and subsequent RTC by 27 years, controlling for substance use and driving-risk activities.ResultsBy 27 years of age, of 937 participants, 386 (41.2%) reported zero crashes and 551 (58.8%) reported ≥1 crashes. In the baseline Poisson model, increased Externalising scores (eg, aggression and delinquency) were associated with increased RTC (incidence rate ratio (IRR)=1.02, 95% CI 1.01 to 1.02): increased Internalising scores (eg, anxiety and depression) were associated with fewer RTC (IRR=0.99, 95% CI 0.98 to 1.00). In the fully adjusted model, the mental health measures were not significant (Externalising IRR=1.01, 95% CI 0.99 to 1.02: Internalising IRR=0.99, 95% CI 0.99 to 1.00). Risky driver activities, such as falling asleep while driving (IRR=1.34), more frequent use of a hands-free telephone (IRR=1.35) and more frequent hostility towards other drivers (IRR=1.30) increased the rate of RTC.ConclusionMeasures of mental health scores at age 17 were not predictive of subsequent RTC, after adjusting for measures of driving-risk activities. We need to better understand the determinants of externalising and risky driving behaviours if we are to address the increased risk of RTC.
Occupation and COVID-19 mortality in England: a national linked data study of 14.3 million adults
Authors: Nafilyan Vahe , Pawelek Piotr , Ayoubkhani Daniel , Rhodes Sarah , Pembrey Lucy , Matz Melissa , Coleman Michel , Allemani Claudia , Windsor-Shellard Ben , van Tongeren Martie , Pearce Neil 
Published: December 2021

ObjectivesTo estimate occupational differences in COVID-19 mortality and test whether these are confounded by factors such as regional differences, ethnicity and education or due to non-workplace factors, such as deprivation or prepandemic health.MethodsUsing a cohort study of over 14 million people aged 40–64 years living in England, we analysed occupational differences in death involving COVID-19, assessed between 24 January 2020 and 28 December 2020.We estimated age-standardised mortality rates (ASMRs) per 100 000 person-years at risk stratified by sex and occupation. We estimated the effect of occupation on COVID-19 mortality using Cox proportional hazard models adjusted for confounding factors. We further adjusted for non-workplace factors and interpreted the residual effects of occupation as being due to workplace exposures to SARS-CoV-2.ResultsIn men, the ASMRs were highest among those working as taxi and cab drivers or chauffeurs at 119.7 deaths per 100 000 (95% CI 98.0 to 141.4), followed by other elementary occupations at 106.5 (84.5 to 132.4) and care workers and home carers at 99.2 (74.5 to 129.4). Adjusting for confounding factors strongly attenuated the HRs for many occupations, but many remained at elevated risk. Adjusting for living conditions reduced further the HRs, and many occupations were no longer at excess risk. For most occupations, confounding factors and mediators other than workplace exposure to SARS-CoV-2 explained 70%–80% of the excess age-adjusted occupational differences.ConclusionsWorking conditions play a role in COVID-19 mortality, particularly in occupations involving contact with patients or the public. However, there is also a substantial contribution from non-workplace factors.
Clinician and patient experience of neurology telephone consultations during the COVID-19 pandemic
Authors: Nakornchai Tagore , Conci Elena , Hensiek Anke , Brown J William L 
Published: December 2021

AbstractBackgroundTelephone consultations are already employed in specific neurological settings. At Cambridge University Hospitals, the COVID-19 pandemic initially prompted almost all face-to-face appointments to be delivered by telephone, providing a uniquely unselected population to assess.ObjectivesWe explored patient and clinician experience of telephone consultations; and whether telephone consultations might be preferable for preidentifiable subgroups of patients after the pandemic.MethodsClinicians delivering neurological consultations converted to telephone between April and July 2020 were invited to complete a questionnaire following each consult (430 respondents) and the corresponding patients were subsequently surveyed (290 respondents). The questionnaires assessed clinician and patient goal achievement (and the reasons for any dissatisfaction). Clinicians also described consultation duration (in comparison to face to face) while patients detailed comparative convenience and preference.ResultsThe majority of clinicians (335/430, 78%) and patients (227/290, 78%) achieved their consultation goals by telephone, particularly during follow-up consultations (clinicians 272/329, 83%, patients 176/216, 81%) and in some disease subgroups (eg, seizures/epilepsy (clinicians 114/122 (93%), patients 71/81 (88%)). 95% of telephone consultations were estimated to take the same or less time than an equivalent face-to-face consultation. Most patients found telephone consultations convenient (69%) with 149/211 (71%) indicating they would like telephone or video consultations to play some role in their future follow-up.ConclusionTelephone consultations appear effective, convenient and popular in prespecified subgroups of neurological outpatients. Further work comparing telephone, video and face-to-face consultations across multiple centres is now needed.
RF system challenges for future $$\hbox {e}^+ \hbox {e}^-$$ circular colliders
Authors: Brunner Olivier , Jensen Erk , Karpov Ivan , Montesinos Eric , Peauger Franck , Syratchev Igor 
Published: December 2021

AbstractThe RF system is the centrepiece of any future circular lepton collider. In particular, the system is required to support the high intensity beams needed for pushing the luminosity at the lower energy regimes of future energy-frontier circular lepton colliders (e.g. for operation in the Z peak and at the WW threshold). Capturing, storing the beam and replacing energy losses from synchrotron radiation demand low frequency, low shunt resistance cavities, low number of cells and high RF power per cell. Controlling the beam both transversely and longitudinally requires sophisticated beam control and timing systems. Additional RF systems are used to ensure transverse stability (feedback systems) and to increase the luminosity (crab cavities). Operation at high energies (such as the ZH and $${\mathrm{t}{\overline{\mathrm{t}}}}$$

t

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threshold) requires a very large accelerating voltage, since synchrotron radiation leads to significantly higher energy losses per turn which must be compensated. Since the RF system is to be optimised in size and energy efficiency for varying demands for the different operational modes, the spectrum of R &D challenges covers a wide range of technologies.
Janus
Authors: Istomin Timofei , Leoni Elia , Molteni Davide , Murphy Amy L. , Picco Gian Pietro , Griva Maurizio 
Published: December 2021

Proximity detection is at the core of several mobile and ubiquitous computing applications. These include reactive use cases, e.g., alerting individuals of hazards or interaction opportunities, and others concerned only with logging proximity data, e.g., for offline analysis and modeling. Common approaches rely on Bluetooth Low Energy (BLE) or ultra-wideband (UWB) radios. Nevertheless, these strike opposite tradeoffs between the accuracy of distance estimates quantifying proximity and the energy efficiency affecting system lifetime, effectively forcing a choice between the two and ultimately constraining applicability.
Janus reconciles these dimensions in a dual-radio protocol enabling accurate and energy-efficient proximity detection, where the energy-savvy BLE is exploited to discover devices and coordinate their distance measurements, acquired via the energy-hungry UWB. A model supports domain experts in configuring Janus for their use cases with predictable performance. The latency, reliability, and accuracy of Janus are evaluated experimentally, including realistic scenarios endowed with the mm-level ground truth provided by a motion capture system. Energy measurements show that Janus achieves weeks to months of autonomous operation, depending on the use case configuration. Finally, several large-scale campaigns exemplify its practical usefulness in real-world contexts.
Intravenous Thrombolysis After First-Ever Ischemic Stroke and Reduced Incident Dementia Rate
Authors: Cerasuolo Joshua O. , Mandzia Jennifer , Cipriano Lauren E. , Kapral Moira K. , Fang Jiming , Hachinski Vladimir , Sposato Luciano A. 
Published: December 2021

Background:
The use of intravenous thrombolysis is associated with improved clinical outcomes. Whether thrombolysis is associated with reduced incidence of poststroke dementia remains uncertain. We sought to estimate if the use of thrombolysis following first-ever ischemic stroke was associated with a reduced rate of incident dementia using a pragmatic observational design.

Methods:
We included first-ever ischemic stroke patients from the Ontario Stroke Registry who had not previously been diagnosed with dementia. The primary outcome was incident dementia ascertained by a validated diagnostic algorithm. We employed inverse probability of treatment-weighted Cox proportional hazard models to estimate the cause-specific hazard ratio for the association of thrombolysis and incident dementia at 1 and 5 years following stroke.

Results:
From July 2003 to March 2013, 7072 patients with ischemic stroke were included, 3276 (46.3%) were female and mean age was 71.0 (SD, 12.8) years. Overall, 38.2% of the cohort (n=2705) received thrombolysis, 77.2% (n=2087) of which was administered within 3 hours of stroke onset. In the first year following stroke, thrombolysis administration was associated with a 24% relative reduction in the rate of developing dementia (cause-specific hazard ratio, 0.76 [95% CI, 0.58–0.97]). This association remained significant at 5 years (cause-specific hazard ratio, 0.79 [95% CI, 0.66–0.91]) and at the end of follow-up (median 6.3 years; cause-specific hazard ratio, 0.79 [95% CI, 0.68–0.89]).

Conclusions:
Thrombolysis administration following first-ever ischemic stroke was independently associated with a reduced rate of dementia. Incident dementia should be considered as a relevant outcome when evaluating risk/benefit of thrombolysis in ischemic stroke patients.
Safety and Feasibility of Reconstructing Dissection Tandem Lesions with Flow Diverter Stents during Mechanical Thrombectomy for Acute Ischemic Stroke: A Multicenter Retrospective Case Series
Authors: Diaz‐Silva Humberto , Piñana Carlos , Gramegna Laura Ludovica , Requena Manuel , Rivera Eila , González Eva María , Fondevila Monsó Juan José , Chirife Oscar , Moreu Manuel , Vega Pedro , Remollo Sebastià , Martínez Mario , Galván Jorge , Schuller Miguel , Cirillo Luigi , Hernández David , Ribo Marc , Tomasello Alejandro 
Published: December 2021

Background
Patients with acute ischemic stroke due to large vessel occlusion may present with concomitant carotid dissections that make the technical approach for their treatment challenging. The purpose of this study was to determine the safety and feasibility of flow diverter (FD) stents to treat carotid artery dissections in tandem lesions of acute ischemic stroke patients during mechanical thrombectomy.

Methods
A retrospective review of all patients in which a carotid artery dissection was treated with an FD during endovascular treatment of acute ischemic stroke between 2018 and 2020 was conducted in 5 high‐volume Comprehensive Stroke Centers. Patient clinical and angiographical characteristics, postoperative outcome, and follow‐up were recorded.

Results
A total of 12 patients (mean age: 54.18±14.74 years, median Alberta Stroke Program Early CT Score: 10 [interquartile range 9–10]) were included. Successful FD stenting with immediate patency of the dissected segments and successful intracranial recanalization modified thrombolysis in cerebral infarction score 2b‐3 after thrombectomy was achieved in all patients. A good outcome (modified Rankin scale 0–2 at 90 days) was achieved in 66% (8/12) of patients. In 25% (3/12) of patients, an additional self‐expanding carotid stent was used to anchor the FD proximally at the carotid bulb level. Complications included 1 symptomatic intracranial hemorrhage after procedure (24–48 hours) and 2 in‐stent stenoses at follow‐up.

Conclusions
In this small case series, the treatment of carotid artery dissection with FD stents was safe and technically feasible during mechanical thrombectomy of acute ischemic stroke patients with tandem lesions and resulted in a high rate of good clinical outcome. These results may provide the basis for designing larger prospective studies to assess the efficacy and safety of FD stents in selected patients with carotid tandem lesions.
The Four Signs of the Art: Edition and Translation of an Alchemical Epistle Attributed to Ḫālid b. Yazīd and its Latin Translation
Authors: Dapsens Marion , Moureau Sébastien 
Published: December 2021

Abstract
In the article, the authors present a study, a critical edition and an English translation of an Arabic alchemical epistle attributed to the Umayyad prince Ḫālid b. Yazīd, together with its Latin translation recently identified by the authors. Among the many alchemical works attributed to Ḫālid b. Yazīd, this untitled Risāla (inc.: ‮إني رأيت الناس طلبوا صنعة الحكمة‬‎) is the second most represented in the manuscript tradition, with no less than twelve witnesses containing it. Its partial Latin translation, available in six manuscripts, was also attributed to Calid, but the name of the translator remains unknown.