bluuebunny/crossref_metadata_2025_split huggingface dataset:
PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells
Authors: Kusama Kazuya , Fukushima Yuta , Yoshida Kanoko , Azumi Mana , Yoshie Mikihiro , Mizuno Yumi , Kajihara Takeshi , Tamura Kazuhiro 
Published: October 2021

Abstract
Endometriosis is characterized by inflammation and fibrotic changes. Our previous study using a mouse model showed that proinflammatory factors present in peritoneal hemorrhage exacerbated inflammation in endometriosis-like grafts, at least in part through the activation of prostaglandin (PG) E2 receptor and protease-activated receptor (PAR). In addition, menstruation-related factors, PGE2 and thrombin (P/T), a PAR1 agonist induced epithelial-mesenchymal transition (EMT) of endometrial cells under hypoxia. However, the molecular mechanisms by which P/T induce development of endometriosis have not been fully characterized. To investigate the effects of P/T, RNA extracted from endometrial stromal cells (ESCs) treated with P/T were subjected to RNA sequence analysis, and identified activin A, FOS, and GATA2 as upregulated genes. Activin A increased the expression of connective tissue growth factor (CTGF) and mesenchymal marker genes in ESCs. CTGF induced the expression of fibrosis marker type I collagen, fibronectin, and α-smooth muscle actin (αSMA), indicating fibroblast to myofibroblast transdifferentiation (FMT) of ESCs. In addition, activin A, FOS, GATA2, CTGF, and αSMA were localized in endometriosis lesions. Taken together, our data show that P/T induces changes resembling EMT and FMT in ectopic ESCs derived from retrograde menstruation, and that these are associated with fibrotic changes in the lesions. Pharmacological means that block P/T-induced activin A and CTGF signaling may be strategies to inhibit fibrosis in endometriotic lesions.
Great power comes at a high (locomotor) cost: the role of muscle fascicle length in the power versus economy performance trade-off
Authors: Cooper Amanda N. , McDermott William J. , Martin James C. , Dulaney Shea O. , Carrier David R. 
Published: October 2021

ABSTRACT
Muscle design constraints preclude simultaneous specialization of the vertebrate locomotor system for explosive and economical force generation. The resulting performance trade-off between power and economy has been attributed primarily to individual differences in muscle fiber type composition. While certainly crucial for performance specialization, fiber type likely interacts with muscle architectural parameters, such as fascicle length, to produce this trade-off. Longer fascicles composed of more serial sarcomeres can achieve faster shortening velocities, allowing for greater power production. Long fascicles likely reduce economy, however, because more energy-consuming contractile units are activated for a given force production. We hypothesized that longer fascicles are associated with both increased power production and locomotor cost. In 11 power-trained and 13 endurance-trained recreational athletes, we measured (1) muscle fascicle length via ultrasound in the gastrocnemius lateralis, gastrocnemius medialis and vastus lateralis, (2) maximal power during cycling and countermovement jumps, and (3) running cost of transport. We estimated muscle fiber type non-invasively based on the pedaling rate at which maximal cycling power occurred. As predicted, longer gastrocnemius muscle fascicles were correlated with greater lower-body power production and cost of transport. Multiple regression analyses revealed that variability in maximal power was explained by fiber type (46% for cycling, 24% for jumping) and average fascicle length (20% for cycling, 13% for jumping), while average fascicle length accounted for 15% of the variation in cost of transport. These results suggest that, at least for certain muscles, fascicle length plays an important role in the power versus economy performance trade-off.
The association between FOXO3a rs4946936 gene polymorphism and the levels of FOXO3a among chronic granulocytic leukemia patients treated with imatinib mesylate
Authors: Wardhani Shinta Oktya , Susianti Hani , Rahayu Puji , Yueniwati Yuyun Prabowowati , Fajar Jonny Karunia 
Published: October 2021

Background: The gene FOXO3a has been elucidated to govern the development of chronic granulocytic leukemia (CGL). Moreover, it has been suggested that the levels of FOXO3a in circulation are affected by the FOXO3a rs4946936 gene polymorphism. However, no study has assessed the correlation between the FOXO3a rs4946936 gene polymorphism and the levels of FOXO3a. The objective of this study was to assess the association between the FOXO3a rs4946936 gene polymorphism and the levels of FOXO3a in CGL patients treated with imatinib mesylate. Methods: A cross-sectional study was conducted from February 2019 to February 2020. The genotyping of FOXO3a rs4946936 gene polymorphism was conducted using PCR-RFLP, and the levels of FOXO3a were assessed using ELISA. The association between the FOXO3a rs4946936 gene polymorphism and the levels of FOXO3a were assessed using multiple logistic regression. Results: A total of 60 CGL patients were assessed in our study. Among them, the CC, CT, and TT genotypes of the FOXO3a rs4946936 gene polymorphism were 35.0%, 48.3%, and 16.7% respectively. Our calculation revealed that elevated levels of FOXO3a were found in CGL patients with the CC genotype of the FOXO3a rs4946936 gene polymorphism. While we failed to clarify the association between either the CT or the TT genotype of FOXO3a rs4946936 gene polymorphism and the levels of FOXO3a. Conclusion: Our study identifies that the CC genotype of the FOXO3a rs4946936 gene polymorphism affects the elevated levels of FOXO3a in CGL patients treated with imatinib mesylate.
ОСОБЕННОСТИ ПРОЯВЛЕНИЯ ШКОЛЬНОГО БУЛЛИНГА У ПОДРОСТКОВ
Authors: Romanova Marina V. , Frolkina Alyona V. 
Published: October 2021

Цель. Статья посвящена наиболее актуальной теме в современной психологии. Целью работы является изучение особенностей проявления школьного буллинга у подростков.
Методология и методы работы. В качестве методологической основы исследования выступают работы отечественных и зарубежных исследователей, в которых раскрываются понятие «буллинг». Основным методом исследования является тестирование.
Результаты. Статья включает в себя теоретический анализ изучаемого феномена. Обозначены результаты исследования проявления буллинга у подростков из сельских и городских школ. Эмпирически доказаны различия в проявлении школьного буллинга подростками из различных исследуемых групп.
Область применения результатов. Результаты исследования могут быть применены в учебно-воспитательном процессе городских и сельских школ, а также в рамках профилактических и психокоррекционных работ с подростками, склонных к проявлению буллинга.
Building a Productive Workforce: The Role of Structured Management Practices
Authors: Cornwell Christopher , Schmutte Ian M. , Scur Daniela 
Published: October 2021

In an influential study, Bender et al. [Bender S, Bloom N, Card D, Van Reenen J, Wolter S (2018) Management practices, workforce selection, and productivity. J. Labor Econom. 36(S1):S371–S409] document consistent relationships between management practices, productivity, and workforce composition using administrative data from German firms matched to ratings of their practices from the World Management Survey. We replicate and extend their analysis using comparable data from Brazil. The main conclusions from their study are supported in ours, strengthening the view that more structured practices affect organizational performance through workforce selection across different institutional settings. However, we find that more structured management practices are linked to greater wage inequality in Brazil, relative to greater wage compression in Germany, suggesting that some of the consequences of adopting structured practices are tied to the local context. This paper was accepted by Joshua Gans, business strategy.
Exploiting Random Lead Times for Significant Inventory Cost Savings
Authors: Stolyar Alexander L. , Wang Qiong 
Published: October 2021

Taking Advantage of the Lead Time Randomness in Supply Chains Randomness in lead times is a major—and increasingly important—issue of inventory management, as a variety of risk factors motivate companies to diversify their supply sources and rely on distributed networks of suppliers. In “Exploiting Random Lead Times for Significant Inventory Cost Savings,” A. Stolyar and Q. Wang show that, surprisingly, instead of being a damaging factor to supply chain performance, randomness may be harnessed for potentially very substantial reductions of inventory costs. Specifically, the theoretical analysis and simulation results in the paper demonstrate that, under certain conditions, appropriately designed novel policies can significantly outperform the conventional base stock policies.
Satisfação no trabalho de técnicos de enfermagem do atendimento pré-hospitalar: um estudo observacional analítico
Authors: Moura André Almeida de , Bernardes Andrea , Dessotte Carina Aparecida Marosti , Balsanelli Alexandre Pazetto , Zanetti Ariane Cristina Barboza 
Published: October 2021

Objetivo: avaliar a satisfação no trabalho dos técnicos de enfermagem atuantes no Serviço de Atendimento Móvel de Urgência e sua relação com variáveis relacionadas aos aspectos profissionais e demográficos. Método: estudo observacional analítico, com 155 técnicos de enfermagem do Serviço de Atendimento Móvel de Urgência. Empregaram-se o Job Satisfaction Survey e testes estatísticos não paramétricos para analisar a correlação e a associação entre as dimensões do instrumento com as variáveis sociodemográficas e profissionais, com nível de significância de p<0,05. Resultados: os profissionais estão nem insatisfeitos nem satisfeitos em relação ao seu trabalho. Identificaram-se correlações fracas entre alguns domínios do instrumento com as variáveis idade e tempo na unidade. Houve associações entre a satisfação no trabalho com as variáveis: sexo, graduação, escala e tipo de vínculo. Conclusão: evidenciou-se que a satisfação no trabalho dos técnicos de enfermagem atuantes no atendimento pré-hospitalar está associada às variáveis sexo, graduação, escala de serviço e tipo de vínculo.
Efficacy of targeted indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-resistant Aedes aegypti
Authors: Che-Mendoza Azael , González-Olvera Gabriela , Medina-Barreiro Anuar , Arisqueta-Chablé Carlos , Bibiano-Marin Wilberth , Correa-Morales Fabián , Kirstein Oscar D. , Manrique-Saide Pablo , Vazquez-Prokopec Gonzalo M. 
Published: October 2021

Background
There is an increased need to mitigate the emergence of insecticide resistance and incorporate new formulations and modes of application to control the urban vector Aedes aegypti. Most research and development of insecticide formulations for the control of Ae. aegypti has focused on their peridomestic use as truck-mounted ULV-sprays or thermal fogs despite the widespread knowledge that most resting Ae. aegypti are found indoors. A recent modification of indoor residual spraying (IRS), termed targeted IRS (TIRS) works by restricting applications to 1.5 m down to the floor and on key Ae. aegypti resting sites (under furniture). TIRS also opens the possibility of evaluating novel residual insecticide formulations currently being developed for malaria IRS.

Methods
We evaluated the residual efficacy of chlorfenapyr, formulated as Sylando 240SC, for 12 months on free-flying field-derived pyrethroid-resistant Ae. aegypti using a novel experimental house design in Merida, Mexico. On a monthly basis, 600 female Ae. aegypti were released into the houses and left indoors with access to sugar solution for 24 hours. After the exposure period, dead and alive mosquitoes were counted in houses treated with chlorfenapyr as well as untreated control houses to calculate 24-h mortality. An evaluation for these exposed cohorts of surviving mosquitoes was extended up to seven days under laboratory conditions to quantify “delayed mortality”.

Results
Mean acute (24-h) mortality of pyrethroid-resistant Ae. aegypti ranged 80–97% over 5 months, dropping below 30% after 7 months post-TIRS. If delayed mortality was considered (quantifying mosquito mortality up to 7 days after exposure), residual efficacy was above 90% for up to 7 months post-TIRS application. Generalized Additive Mixed Models quantified a residual efficacy of chlorfenapyr of 225 days (ca. 7.5 months).

Conclusions
Chlorfenapyr represents a new option for TIRS control of Ae. aegypti in urban areas, providing a highly-effective time of protection against indoor Ae. aegypti females of up to 7 months.
The Effects on Corporate Social Responsibility by Shares and Teamwork Culture
Authors: HUANG CHI FEN , Lin Jer-Yan 
Published: October 2021

Corporate social responsibility has become an international trend in order to maximize profits and attract the attention of scholars and practitioners. Therefore Engaging in corporate social responsibility may affect the company's profits and cause increased costs. The social responsibility plan should determine the most necessary strategic concerns and the creating important value. Therefore Social responsibility is the key to an enterprise's pursuit of excellence. Creating social well-being and enhancing its competitive advantage may be an important factor for the company's future success. Promoting corporate social responsibility with shares and establishing a sustainable team-oriented culture can enhance corporate competitive advantages, create social well-being, and create value to stimulate Innovative.
The empirical results showed that shares and team-oriented culture have significantly positive impact on corporate social responsibility that is further positively significant to enhance employee innovation behavior. Further finding supports that environmental altruism moderates the relationship between corporate social responsibility and shares.
NCP 5 – Tangible Fixed Assets
Authors: Pereira Adalmiro Andrade 
Published: October 2021

2015 saw an important step in the accounting reform in Portugal. On September 11, 2015, the Accounting Standardization System for Public Administrations (SNC-AP) was approved through Decree-Law No. 192/2015, which revokes the Official Public Accounting Plan (POCP) and establishes an accounting standard aligned with international accounting standards.
The development of this work is based on content analysis focused on Public Accounting Standard 5, NCP 5, which was broken down into the respective chapters of the regulations.
In this way, to reach the objective of the study, work was developed on several themes, which are essentially based on the chapters of NCP 5. In this way, the topics covered are: Objectives, Scope and Definitions, Measurement, Recognition and Derecognition; and, in order to better contextualize and exemplify the practical application of the standard, we will find, at the end of this work, some practical situations.
Facilitation and Service Delivery in the National Police Service in Nairobi County, Kenya
Authors: Nassiuma Bernard Kibeti , Young Ogola Humphrey , Mwangi Kung’u David 
Published: October 2021

Purpose: The purpose of the study was to evaluate the effects of facilitation on service delivery in the National Police Service (NPS), Nairobi County, Kenya. The study was anchored on the New Public Management Theory; it heralds the transformation of citizens into customers of public services who deserve feedback on police service delivery.
Methodology: Pragmatic philosophical approach was used to support this study. The qualitative and quantitative methods of inquiry were used to generate evidence to support the evaluation. The target population for the study was 2100 police officers in Nairobi County from which a sample of 215 respondents was selected using simple random sampling techniques. While the members 105 of the public were purposely selected. Questionnaires and key informant interview guides were the main data collection tools used in the study. The qualitative data were thematically analyzed while the quantitative data were analyzed using frequency counts, means, standard deviation, multiple regression, chi-square tests, and Pearson and Spearman rank correlation.
Findings: The majority of the respondents in the study were males aged between 26-35 years and over 60% of the respondents were of the opinion that police reforms had increased police mobility. Equally, the majority (64%) indicated that the infrastructure was poor, in addition to poor feedback mechanisms, which affected effective service delivery.
Contribution to Theory Practice and Policy: The study points out the key factors which hinder effective service delivery in the Kenya Police service despite the implementation of police service reforms.
Key Words: Facilitation, Service Delivery, Police Reforms, National Police Service
Alea Ke Pau or Negotiated Evaluation: A Vital Concept in Pacific Health Promotion
Authors: Ofanoa Malakai , Ofanoa Samuela , Buetow Stephen 
Published: October 2021

For Pacific peoples, health promotion, community nursing and community development initiative over many years, has often been conducted within a framework of one-sided decision-making. There is always an imbalance between the power relationships of the community being studied and those of the researchers or health practitioners. As a result, there is lack of understanding on the part of the researchers and the health funding agencies of the need to negotiate processes with members of the community being studied or engaging with. All of this are within an overarching lack of understanding of, and respect for, Pacific cultural values, frameworks and Pacific ways of doing things. This paper seeks to explore an alternative concept whereby these values are acknowledged. This concept is metaphorically called “alea ke pau” (or, negotiated evaluation). This approach is forward-looking and one that respects a ‘bottom-up’ view rather than the traditional ‘top-down’ view of health work and funding agencies.
However, using two Pacific research methodologies called Talanga and Kakala, to explore the concept of alea ke pau were held with five men’s focus groups operating within Kava Clubs in Auckland, New Zealand, and five focus groups in Tonga. The results from these discussions are presented demonstrating the development and application of the “alea ke pau” or “negotiated evaluation” approach.
KAVA CONSUMPTION AND FAMILY VIOLENCE
Authors: Ofanoa Malakai , Ofanoa Samuela 
Published: October 2021

Kava drinking has become an intrinsic part of Tongan culture. It involves regular participation and high consumption of kava drink in kava clubs and other kava venues in Tonga and New Zealand. However, mounting evidence has indicated that the reasons for, and perceived effects of kava consumption are yet to be fully understood (Nosa and Ofanoa, 2009, Ofanoa, 2010). A qualitative study to explore the issues related with Tongan men abusing kava consumption was conducted in Tonga and Auckland, New Zealand (Ofanoa, 2010).

The study used culturally safe, Pacific qualitative research approaches of Kakala (Thaman, 1997) and Talanga (Ofanoa, 2010) to obtain information related to the issue. There were focus group interviews conducted with a convenience sample of 104 Tongan men across 5 kava clubs each in Tonga and Auckland, New Zealand. The analysis of the focus group interviews in both places involved a general inductive approach.

The findings reported that kava use is socially sanctioned and easily accessible in both countries. Further, kava presents concerning health and social issues. It increases poor family relationships that leads to family violence. Usually the family violence happens after kava sessions. The Kava men sleep long hours; they spent a lot of their family income in Kava sessions and makes many excuses.
Moreover, kava men are usually very lazy to work, and slow to recover in the next day. Hence, the poor wives usually shoulder everything in the family. In many instances, some of them behave violently and aggressively. When such practices happen consistently, family violence starts, and many husbands physically abuse their wives. Evidently, one end up in the hospital with serious injuries or both husband and wife appear in court.
The study concludes that Tongan men in both countries cannot continue to hide the truth that their abusive consumption of kava contributes to family violence. Hence, there is a tremendous need for urgent actions to prevent and minimize this practice. Further, since addressing the issue is sensitive and complex, a call for multi-sectoral and multi-disciplinary effort with the Tongan society in both Tonga and New Zealand is required to minimize the risks and optimize the benefits of kava use.
Study on the thermal insulation performance of the core–shell skeleton graphene oxide/carbon composite aerogel
Authors: Liu Hongli , Wang Peng , Yuan Wenjin , Li Hongyan 
Published: October 2021

Abstract
Phenolic resin (PR) was grafted onto the surface of graphene oxide (GO) through π–π conjugation and chemical bonding. After carbonization, organic compounds turned into carbon layers with a thickness of about 10 nm and coated on the surface of GO formed a core–shell structure. Besides, the adiabatic interface formed during organic carbonization can effectively connect the aerogels into a three-dimensional network. The optimum mass ratio of GO was determined to be 10 wt% in the preparation of the precursor aerogel. The adiabatic interfaces (carbon) between GO lamellae could effectively reduce the solid phase heat transfer in aerogels (thermal conductivity is 0.0457 W m−1 K−1). At the same time, the existence of GO also ensured better mechanical properties of GO/carbon composite aerogel (compressive strength is 2.43 MPa) compared with the pure carbon aerogel (1.52 MPa), demonstrating the excellent heat-shielding performance and mechanical property of GO/carbon aerogel.
Phosphorylation of CREB at Serine 142 and 143 Is Essential for Visual Cortex Plasticity
Authors: Pulimood Nisha S. , Contreras Minerva , Pruitt Molly E. , Tarasiewicz Agnieszka , Medina Alexandre E. 
Published: October 2021

AbstractThe transcription factor cAMP response element-binding protein (CREB) is involved in a myriad of cellular functions in the central nervous system. For instance, the role of CREB via phosphorylation at the amino-acid residue Serine (Ser)133 in expressing plasticity-related genes and activity-dependent neuronal plasticity processes has been extensively demonstrated. However, much less is known about the role of CREB phosphorylation at Ser142 and Ser143. Here, we employed a viral vector containing a dominant negative form of CREB, with serine-to-alanine mutations at residue 142 and 143 to specifically block phosphorylation at both sites. We then transfected this vector into primary neuronsin vitroor intracortically injected it into micein vivo, to test whether these phosphorylation events were important for activity-dependent plasticity. We demonstrated by immunohistochemistry of cortical neuronal cultures that the expression of Arc, a known plasticity-related gene, requires triple phosphorylation of CREB at Ser133, Ser142, and Ser143. Moreover, we recorded visually-evoked field potentials in awake mice before and after a 7-d period of monocular deprivation (MD) to show that, in addition to CREB phosphorylation at Ser133, ocular dominance plasticity (ODP) in the visual cortex also requires CREB phosphorylation at Ser142/143. Our findings suggest that Ser142/143 phosphorylation is an additional post-translational modification of CREB that triggers the expression of specific target genes and activity-dependent neuronal plasticity processes.