bluuebunny/crossref_metadata_2025_split huggingface dataset:
MODERN CRITERIA FOR THE SELECTION OF HEAD AND NECK CANCER PATIENTS FOR RECONSTRUCTION OF THE UPPER AERODIGESTIVE TRACT BY THE VISCERAL FLAPS
Authors: Ratushny M. V. , Polyakov A. P. , Kaprin A. D. , Reshetov I. V. , Rebrikova I. V. , Mordovskiy A. V. 
Published: June 2021

Introduction. The high incidence of cancer of the upper aerodigestive tract, impairment of breathing, speech, and swallowing functions accompanied by prolonged and often persistent disability put the rehabilitation and the quality of life of patients among the most important social problems.Material and methods. We have gained experience in reconstructing the pharynx and esophagus with various fragments of the gastrointestinal tract in 121 cancer patients. Based on our own clinical experience, the most important criteria of selecting patients after laryngectomy for reconstruction of the upper aerodigestive tract with visceral flaps were identified. Visceral autografts formed from different parts of the patient’s gastrointestinal tract were full-layer fragments of the abdominal organs, which included the mucous membrane of the stomach, small intestine, or large intestine. In some patients, the choice of flap was limited by a large omentum.Results. In 9.9 % of cases, flap necrosis was observed. Oral nutrition was restored in 93.9 % of patients. In 90.5 % of cases, speech function was restored after the installation of avoice prosthesis. The method of autologous transplantation of the ileo-colonic flap made it possible not only to remove the organs affected by the tumor, but also to simultaneously restore the lost nutrition and vocal functions without resorting to artificial prostheses, but using only their own tissues. The 5-year survival rates were 36.4 % and 67.3 % in patients with simultaneous reconstruction and in patients with delayed reconstruction, respectively.Conclusion. The use of visceral flaps in the reconstruction of the upper aerodigestive tract allows patients to restore both the nutrition and voice functions after laryngectomy.
STAGE IB2–IIIB CERVICAL CANCER: NEOADJUVANT CHEMOTHERAPY, RADICAL SURGERY AND PATIENT SURVIVAL
Authors: Ovodenko D. L. , Khabas G. N. , Kreinina Yu. M. , Seregin A. A. , Aleshikova O. I. , Ashrafyan L. A. 
Published: June 2021

The aim of the study was to evaluate the five-year survival rate in patients with stage ib2–iiib cervical cancer treated with neoadjuvant chemotherapy and radical surgery.Material and Methods. Long-term treatment outcomes were studied in 173 patients with histologically-verified stage ib2–iiib cervical squamous cell carcinoma. The patients underwent neoadjuvant chemotherapy using intravenous infusion of cytostatic drugs (n=106) and intra-arterial infusion of cytostatic drugs in combination with embolization of tumor-feeding arteries (n=67). Patients with resectable tumors underwent radical surgery. Disease-free survival was assessed.Results. The median follow-up time was 66 months, and the maximum follow-up period was 144 months. 160 (92.5 %) patients underwent radical surgery after chemotherapy. 55 (34.4 %) patients did not receive adjuvant radiation therapy. The five-year disease-free survival rate was 79.6 %.Conclusion. For the group of patients with locally advanced cervical cancer, who achieved respectability following neoadjuvant chemotherapy, radical surgery could be performed. Chemotherapy followed by radical surgery can improve disease-free survival rates in patients with stage ib2–iiib cervical cancer.
Characterization of Al2O3 reinforced Al 6061 metal matrix composite
Authors: Bhat Avinash , Kakandikar Ganesh , Deshpande Abhijeet , Kulkarni Atul , Thakur Dinesh 
Published: June 2021

Composites are a class of materials that give the desired individual tribological and mechanical characteristics. In composite materials, more than two materials are combined to provide a unique combination of properties. This article describes the tribological and mechanical properties of Al6061 reinforced with Al2O3, found experimentally. This article describes the preparation of Al6061 composites with 5 % Al2O3 (size 50 microns) by stir casting process. The hardness of Al6061 with and without amplification was found out with the help of Rockwell hardness tester for 10 seconds at a load of 100 kg. It was found that the hardness of Al2O3 reinforced Al6061 increases compared to unreinforced Al6061. The characteristics related to wear of Al6061 and the new composite material Al6061+Al2O3 were studied. The “pin on disk” method was used with the variation of load varying from 5N-200N and a speed range of 200-1500. An analysis of the sensitivity of key parameters such as load and speed is also described. The results show that the newly developed composite material has a lesser specific rate of wear.
Antimicrobial Activities of Various Thiazine Based Heterocyclic Compounds:
A Mini-Review
Authors: Asif Mohammad , Imran Mohd. , Abida  
Published: June 2021

:
Heterocyclic compounds play a vital role in the development of novel compounds because
of their diverse pharmacological activities. Thiazine is a six-membered heterocyclic moiety.
Various thiazine derivatives were synthesized or isolated from natural sources like plants and animals.
Thiazine derivatives have varieties of pharmacological activities such as antimicrobial, antibacterial,
antifungal, antiviral, anti-inflammatory, anticoagulant, anticancer, antihypertensive, and
other useful biological as well as chemical applications. In the therapy of antimicrobial infections,
new antimicrobial agents are needed because current antimicrobials have developed drug resistance.
So, we discussed some thiazine derivatives, which exhibited antimicrobial activity.
Ground Photometric Measurements Inversion Methods for Space Object
Characteristics Based on Non-linear Filtering: A Short Review
Authors: Wang Yang , Du Xiaoping , Xu Can , Ma Zhihao , Yin Zhiyong 
Published: June 2021

:
The ground space optical observation system considered as one of the main
measurement methods to observe space object in Medium Earth Orbit (MEO), Highly Elliptical
Orbit (HEO) and Geostationary Orbit (GEO) faces difficulties in forming high-solution images for
objects located in GEO that only appears several light spots with limited pixels due to the impacts
of observing distance, resolution ratio, and other atmospheric conditions. The light curve is the
time history of an object’s observed brightness obtained from the ground-based optical observation
system through light curves, right ascension, and declination of space objects. The characteristic of
space objects such as position, velocity, size, shape, and material can be inverted. This paper has
analyzed the principles, applications, merits, and demerits of several non-linear filtering methods
in detail. Besides, the scientific description of inversion for characteristics of a non-resolved space
object from ground photometric measurements and the essence of the non-linear filtering inversion
method has also been clarified. A selection principle of the non-linear filtering inversion method
for different space object characteristics is then proposed, and the developing direction of such
inversion methods is also described in the end.
Optimization of an EMU train carbody by the value of the natural bending frequency
Authors: Guchinsky R. V. 
Published: June 2021

Finding ways to optimize the body structure is an important point in the design of new electric train cars. Reducing the mass of the body leads to a lightening of the parts of the rolling stock associated with it, a reduction in energy consumption for operation and a decrease in wear in the “wheel — rail”system. Reducing the weight of the body is possible by assigning optimal rigidity to its main load-bearing elements. Increasing the rigidity of the body with a constant mass is also an important task to obtain the standard dynamic properties of the car body.The article presents method for optimizing the body structure based on calculating the value of its first frequency of natural bending vibrations. The calculation was carried out by the finite element method using a simplified beam-shell parametric model. Within the optimization calculations, 3125 working versions of sections of the main load-bearing structural elements with different rigidity were considered — bracing and cross-beams of the frame, inter-window racks and cross-beams of the roof. The sensitivity of the value of the natural vibration frequency to the change in the rigidity of the main bearing elements without taking into account the change in mass is analyzed. It was found that the rigidity of the frame bracing and cross beams has the greatest influence on the frequency value. It is shown that the ratio of the rigidity of the main bearing elements does not remain constant for optimal design options and depends on the design of the body, the target values of its mass and rigidity. When mass is limited, it is possible to choose designs that are characterized by the greatest overall body rigidity and are the most optimal in terms of manufacturability. By limiting the values of natural vibration frequency, it is possible to choose a body structure with the lowest metal mass. The presented approach allows making decisions on body modification based on the required parameters of mass and (or) the frequency of natural bending vibrations. This approach can be used in pre-design studies of the bodies of new passenger rolling stock.
Incorporating Unstructured Patient Narratives and Health Insurance Claims Data in Pharmacovigilance: Natural Language Processing Analysis of Patient-Generated Texts About Systemic Lupus Erythematosus
Authors: Matsuda Shinichi , Ohtomo Takumi , Tomizawa Shiho , Miyano Yuki , Mogi Miwako , Kuriki Hiroshi , Nakayama Terumi , Watanabe Shinichi 
Published: June 2021

Background
Gaining insights that cannot be obtained from health care databases from patients has become an important topic in pharmacovigilance.

Objective
Our objective was to demonstrate a use case, in which patient-generated data were incorporated in pharmacovigilance, to understand the epidemiology and burden of illness in Japanese patients with systemic lupus erythematosus.

Methods
We used data on systemic lupus erythematosus, an autoimmune disease that substantially impairs quality of life, from 2 independent data sets. To understand the disease’s epidemiology, we analyzed a Japanese health insurance claims database. To understand the disease’s burden, we analyzed text data collected from Japanese disease blogs (tōbyōki) written by patients with systemic lupus erythematosus. Natural language processing was applied to these texts to identify frequent patient-level complaints, and term frequency–inverse document frequency was used to explore patient burden during treatment. We explored health-related quality of life based on patient descriptions.

Results
We analyzed data from 4694 and 635 patients with systemic lupus erythematosus in the health insurance claims database and tōbyōki blogs, respectively. Based on health insurance claims data, the prevalence of systemic lupus erythematosus is 107.70 per 100,000 persons. Tōbyōki text data analysis showed that pain-related words (eg, pain, severe pain, arthralgia) became more important after starting treatment. We also found an increase in patients’ references to mobility and self-care over time, which indicated increased attention to physical disability due to disease progression.

Conclusions
A classical medical database represents only a part of a patient's entire treatment experience, and analysis using solely such a database cannot represent patient-level symptoms or patient concerns about treatments. This study showed that analysis of tōbyōki blogs can provide added information on patient-level details, advancing patient-centric pharmacovigilance.
Pemodelan Banjir dan Visualisasi Genangan Banjir untuk Mitigasi Bencana di Kali Kasin, Kelurahan Bareng, Kota Malang
Authors: Pratiwi Zafira Nur , Santosa Purnama Budi 
Published: June 2021

Wilayah Kelurahan Kali Kasin di Kota Malang merupakan wilayah padat penduduk yang rentan terhadap banjir. Wilayah ini hamper setiap tahun mengalami banjir, yang berdampak pada kerusakan lingkungan dan infrastruktur. Oleh karena itu, tujuan penelitian ini adalah melakukan pemodelan banjir yang disebabkan oleh luapan Kali Kasin serta melihat cakupan wilayah genangan banjir. Metode pemodelan banjir menggunakan pendekatan hidrolika dalam mensimulasikan debit air pada setiap penggal sungai menggunakan perangkat lunak HEC-RAS, serta melakukan visualisasi daerah genangan banjir serta area terdampak banjir menggunakan pendekan GIS. GIS juga digunakan untuk mempersiapkan beberapa data spasial yang digunakan untuk pemodelan banjir, seperti data geometri sungai, deliniasi daerah aliran sungai, serta untuk keperluan analisis spasial lainnya. Data hidrologis didapat dari pengolahan curah hujan harian pada stasiun hujan wilayah Kali Kasin. Analisis dilakukan dengan menggunakan model SCS CN pada perangkat lunak HEC-HMS untuk memperkirakan debit puncak pada sungai. Sedangkan, sumber data geometrik didapatkan dari Model Elevasi Digital dari citra ALOS PALSAR. Hasil penelitian menunjukkan bahwa pemodelan banjir dapat dilakukan untuk memvisualisasikan daerah genangan banjir di wilayah Kelurahan Bareng. Wilayah yang terdampak banjir seluas 24.225,63 m2. Hasil analisis menunjukkan ada sekitar 173 rumah yang terdampak banjir.
Switch rates and total cost associated with apremilast and biologics in biologic-naive patients with psoriatic arthritis
Authors: Kaplan David L , Ung Brian L , Pelletier Corey , Udeze Chuka , Khilfeh Ibrahim , Tian Marc 
Published: June 2021

Aim:
Real-world treatment data for psoriatic arthritis are limited. We evaluated switch rates, adherence, and costs for patients initiating apremilast versus tumor necrosis factor inhibitor (TNFi) and interleukin inhibitor (ILi) among biologic-naive psoriatic arthritis patients.
Materials & methods:
This retrospective analysis used IBM MarketScan claims data to assess treatment switches, adherence and costs.
Results:
Twelve-month switch rates were significantly lower for apremilast versus TNFi (15.5% vs 26.6%; p < 0.0001) and similar to ILi (15.5% vs 14.0%; p = 0.71). Apremilast initiators had lower total costs versus TNFi and ILi (US$39,854 vs US$57,243 and US$65,687; p < 0.05) and adherence was slightly lower versus TNFi and higher versus ILi.
Conclusion:
Biologic-naive apremilast initiators had lower switch rates versus TNFi initiators and lower total costs versus TNFi or ILi initiators.
Temporalidades de la política en contextos democráticos
Authors: Hernández Alcántara Carlos , Bautista Bravo Alliet 
Published: June 2021

¿Cómo describir las temporalidades de la política en contextos de disputa por el poder en el proceso democrático de 2018 en México? El artículo busca elaborar una respuesta a esta interrogante desde comprender al tiempo como una experiencia de carácter concreto que le confiere posibilidades de autonomía a la política en contextos democráticos. Este postulado nos permite comprender los tiempos de la política como esferas de relaciones de poder desde las siguientes premisas:1) la temporalidad de la continuidad de la política -el poder como realidad concreta-; 2) la temporalidad de igualdad política -el carisma como voluntad colectiva-; y 3) la virtud de la política -el proyecto como esperanza.Las temporalidades de la política combinan de manera vertiginosa negociaciones políticas, discursos, virtudes y acciones colectivas en contextos de disputa electoral. La comprensión de la sagacidad del “ser ahí” es el objeto del discurso que recorre el espacio y la temporalidad relacionados con el “hacer del ser”, es decir, la política, la definen como la política de poder del quehacer humano. Desde esa óptica, los contextos reales de disputa por el poder político de naturaleza democrática, promueven identidades plurales del ser en colectivo, combinando tanto las virtudes de las comunidades políticas como los resultados del “hacer social”. La movilización de la voluntad colectiva contiene una temporalidad real de secuencias hacia horizontes inciertos, a lo imprescindible, a la necesidad de contar con la racionalidad de la política como visión de futuro que incluya al proyecto. Se trata de una forma de esperanza, una construcción social de la política democrática, amoldada por los procesos de aprendizaje interpersonales-horizontales y de los compromisos políticos con los liderazgos carismáticos, partidistas, sociales y culturales.
Transformaciones y tendencias de la radio deportiva en la convergencia digital
Authors: Zambrano William Ricardo 
Published: June 2021

La popularidad del deporte en general y, en particular, del fútbol siempre ha estado en la agenda de la radio colombiana. Ha sido un proceso de más de noventa años donde se han cubierto periodísticamente diferentes disciplinas deportivas a partir de innovadores formatos, estilos, lenguajes, narraciones y transmisiones que han impactado nacional e internacionalmente a la audiencia, situando al periodismo deportivo colombiano como uno de los mejores del mundo. En atención a lo anterior, se investiga la transformación de la radio deportiva análoga a la digital de cuatro programas con mayor sintonía y alcance informativo: El pulso del fútbol y El alargue de Caracol Radio; Planeta fútbol de Antena 2 de RCN Radio; y Blog deportivo de Blu Radio. Esto con el fin de configurar los nuevos perfiles, competencias y tendencias del periodista deportivo del presente siglo.
Para ello, se realiza una investigación mixta, descriptiva, exploratoria y correlacional a través del método de análisis de contenido análogo y digital apoyado en encuestas, entrevistas, grupos de discusión y observación. Estos espacios deportivos radiales están trasladando los mismos contenidos análogos a sus plataformas digitales. La exigencia y la profundidad de sus contenidos y análisis han bajado en calidad; la copia de programas, narrativas y lenguajes de otros países es reiterativo; priman el comentario y la noticia sobre fútbol, se sacrifica la crónica y el reportaje por la especulación. A pesar de ello, estos programas conservan la creatividad, la inmediatez y las tecnologías de vanguardia que siempre los han caracterizado.
Rendimiento diagnóstico de las punciones de lesiones biliopancreáticas guiadas por ultrasonido endoscópico con patólogo en sala
Authors: Mosquera-Klinger Gabriel , Carvajal Gutierrez Jhon Jaime , Echeverri Jaramillo Carolina , Pérez Cadavid Juan Camilo , Cardona Quiceno Ricardo Andrés , Valencia Maturana Julio César , Sánchez Garrido Héctor Andrés 
Published: June 2021

Introducción y objetivos: el ultrasonido endoscópico con punción-aspiración con aguja fina (USE-PAAF) en lesiones neoplásicas biliopancreáticas suele tener un rendimiento alto, que depende de características de la lesión; aspectos técnicos de la USE-PAAF y la experiencia del endoscopista. De los factores menos estudiados es la presencia de patólogo en sala. Se plantea la realización de USE-PAAF con patólogo en sala para disminuir el número de pases, la tasa de muestras inadecuadas y la necesidad de repetir el procedimiento.
Material y métodos: estudio observacional, retrospectivo, con recolección prospectiva de enero de 2018 a junio de 2019, en pacientes adultos sometidos a USE-PAAF. Las muestras obtenidas fueron extendidas y evaluadas en salas de endoscopia por médico patólogo con coloración Diff-Quick y cuando se obtenía una muestra suficiente se enviaba en frasco con formol para bloque celular o biopsias.
Resultados: se realizaron 48 USE-PAAF biliopancreáticas en individuos con una edad mediana de 64 años. Las indicaciones más frecuentes fueron punciones por masa o pseudomasa pancreática (71 % de casos); Se diagnosticaron 35 malignidades (77 % correspondientes a adenocarcinoma, y 14 % a tumores neuroendocrinos). La mediana de tamaño de lesiones fue de 28 mm; el número de pases promedio fue de 3. Se obtuvieron resultados diagnósticos en 89 % frente a 11 % de falsos negativos. Se presentó 1 complicación menor (2,1 %), que fue dolor abdominal.
Conclusiones: la USE-PAAF con patólogo en sala tiene alto rendimiento diagnóstico, con escasos resultados falsos negativos. Se requiere una mediana de pases menor, que podría minimizar los riesgos del procedimiento y la necesidad de repetir la prueba.
High dose pollen intralymphatic immunotherapy: two RDBPC trials question the benefit of dose increase
Authors: Cardell Lars Olaf , Hellkvist Laila , Hjalmarsson Eric , Weinfeld Dan , Dahl Alsog , Karlsson Agneta , Westman Marit , Lundkvist Karin , Winquist Ola , Georén Susanna Kumlien , Westin Ulla 
Published: June 2021

Background The same dosing schedule, 1000 SQ-U times three, with
one-month intervals, have been evaluated in most trials of
intralymphatic immunotherapy (ILIT) for the treatment of allergic
rhinitis (AR). The present studies evaluated if a dose escalation in
ILIT can enhance the clinical and immunological effects, without
compromising safety. Methods Two randomized double-blind
placebo-controlled trials of ILIT for grass pollen induced AR were
performed. The first included 29 patients that had recently ended 3
years of SCIT and the second contained 39 not previously vaccinated
patients. An up-dosage of 1000-3000-10 000 (5000 + 5000 with 30 minutes
apart) SQ-U with one month in between was evaluated. Results Doses up to
10 000 SQ-U was safe after recent SCIT. The combined symptom-medication
scores (CSMS) were reduced by 31% and the grass specific IgG4 levels in
blood were doubled. In ILIT de novo, the two first patients that
received active treatment developed serious adverse reactions at 5000
SQ-U. A modified up-dosing schedule; 1000-3000-3000 SQ-U appeared to be
safe but failed to improve the CSMS. Flow cytometry analyses showed
increased activation of lymph node derived dendritic but not T-cells.
Quality of life and nasal provocation response did not improve in any
study. Conclusion ILIT in high doses after SCIT appears to further
reduce grass pollen induced seasonal symptoms and may be considered as
an add-on treatment for patients that do not reach full symptom control
after SCIT. Up-dosing schedules de novo with three monthly injections
that exceeds 3 000 SQ-U should be avoided.
Investors' Responses to Management Getting Out Ahead of Negative Media Stories: The Moderating Effects of Management's Action Plan and the Media's Focus
Authors: Cikurel Deni , Fanning Kirsten , Jackson Kevin E. 
Published: June 2021

ABSTRACT
Crisis communications experts commonly advise managers to get out ahead of the media to increase management's credibility. We use an experiment to examine how investors' responses to management getting out ahead of a negative media story are moderated by management's action plan and the media's focus on the company. When the company is the focus of the media's lede, investors respond more negatively when the company gets out ahead of the media with plans to change, instead of stay, the course to handle the negative issue. Yet, investors respond more positively when the company responds after the media with plans to change, instead of stay, the course. In contrast, when the media does not focus on the company in its lede, but instead only mentions the company in the story, we find that investors' responses are not sensitive to management's strategic disclosure choices that we examine.