bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alternating bio‐based pyridinic copolymers modified with hydrophilic and hydrophobic spacers as sorbents of aromatic pollutants
Authors: Jlalia Ibtissem , Chabbah Taha , Chatti Saber , Schiets Frédéric , Casabianca Hervé , Marestin Catherine , Mercier Regis , Weidner Steffen M. , Kricheldorf Hans R. , Errachid Abdelhamid , Vulliet Emmanuelle , Hammami Mohamed , Jaffrezic‐Renault Nicole 
Published: December 2021

AbstractThe main objective of this work was to design new advanced sorbent phases, alternating copolymers, derived from isosorbide and 2,6‐difluorpyridine, to be used for the removal of aromatic organic pollutants present in water at low concentrations. Six different monomers, dianhydrohexitols isomers and bisphenol derivatives, were synthesized in order to make it possible to study their hydrophilic and hydrophobic effect on the sorption efficiency of the resulting polymeric phases. Before this study, we have confirmed the chemicals structures, molecular weights, and thermal properties of the obtained polymeric phases. Sorption results show a higher adsorption efficiency of P6 co‐poly(ether‐pyridine) based on bisphenol substituted with pyridine units, for all tested pollutants, hydrophobic and hydrophilic ones, due to its less compact structure. Two aromatic organic pollutants, p‐hydroxybenzoic acid and toluic acid, were selected as sorbates to study the adsorption characteristic, kinetics and isotherms of the co‐poly(ether pyridine) P6. Langmuir model led to a better fitting of the sorption isotherms; the sorption of toluic acid is easier than of that p‐hydroxybenzoic acid. Comparing 1/n values for benzoic acid was two time lower for P6 compared to that for biochar and for cross‐linked methacrylate resin, showing a higher efficiency.
Immune‐related gene expression signatures: a step forward in the stratification of patients with ovarian clear cell carcinoma†
Authors: Pérez‐Mies Belén , Carretero‐Barrio Irene , Palacios José 
Published: December 2021

AbstractClear cell carcinoma of the ovary (CCC) is one of the five major histological types of ovarian cancer and presents specific clinicopathological features, such as a higher prevalence in the Asian population and a poor response to conventional chemotherapy. In a recent publication in The Journal of Pathology, Heong, Tan, Miwa et al demonstrated the heterogeneity of the immune landscape of CCC. They reported the immune signatures observed in a large cohort of CCC, including tumours from both Asian and Caucasian women. The authors analysed three cohorts from Europe, Japan, and Singapore, with a total of 246 tumours, and evaluated 730 immune‐related genes using NanoString technology. The study revealed four main transcriptional subtypes characterised by the expression of specific sets of genes: PD1‐high (11%), CTLA4‐high (29%), antigen‐presentation (42%), and a pro‐angiogenic subtype (18%). The two main conclusions of the study were: (1) that CCCs in women of Asian and Caucasian descent share significant molecular similarities, since all four molecular signatures are present in all the cohorts analysed, without any evident differences in frequency; and (2) that the PD1‐high and CTLA4‐high subtypes were associated with worse clinical outcomes and may be useful when stratifying treatment in early‐stage tumours. The immune signature could represent a promising biomarker of immunotherapy response if future prospective studies confirm it. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Changes in cancer incidence and survival among Aboriginal and Torres Strait Islander children in Australia, 1997–2016
Authors: Youlden Danny R. , Baade Peter D. , McBride Craig A. , Pole Jason D. , Moore Andrew S. , Valery Patricia C. , Young Angela , Aitken Joanne F. 
Published: December 2021

AbstractBackgroundThis study reports cancer incidence and survival among Aboriginal and Torres Strait Islander children and other Australian children, and assesses changes over time.ProcedureData were from the population‐based Australian Childhood Cancer Registry. The study comprised children aged under 15 diagnosed between 1997 and 2016 and with mortality follow‐up until 31 December 2017. Incidence trends were analysed using JoinPoint regression. Five‐year cancer‐specific survival was calculated using the semi‐complete approach with survival comparisons made using multivariable flexible parametric models.ResultsAboriginal and Torres Strait Islander children accounted for 506 of 13,299 eligible cases (3.8%). Incidence rates for Aboriginal and Torres Strait Islander children across the study period increased by 2.3% annually (95% confidence interval [CI]: +0.6% to +4.0%) and for other Australian children increased by 0.6% annually (95% CI: +0.3% to +0.9%; p = .05). Nonetheless, cancer incidence was consistently lower for Aboriginal and Torres Strait Islander children, with an incidence rate ratio of 0.73 (95% CI: 0.62–0.85; p < .01) between 2012 and 2016. Survival for Aboriginal and Torres Strait Islander children with solid tumours was 70.6% (95% CI: 62.5%–77.3%) and for other Australian children was 83.5% (95% CI: 82.3%–84.7%; p < .01), with indications of this difference diminishing in recent years.ConclusionsImprovements in identification, particularly in urban areas, most likely accounts for the greater increase in cancer incidence rates among Aboriginal and Torres Strait Islander children. Examination of data on stage at diagnosis and treatment may provide important insights into survival for children with solid tumours.
Outcomes of Wilms tumor treatment in western Kenya
Authors: Uittenboogaard Aniek , Njuguna Festus , Mostert Saskia , Langat Sandra , van de Velde Mirjam E. , Olbara Gilbert , Vik Terry A. , Kaspers Gertjan J. L. 
Published: December 2021

AbstractBackground/objectivesWilms tumor (WT) is a curable type of cancer with 5‐year survival rates of over 90% in high‐income countries, whereas this is less than 50% in low‐ and middle‐income countries. We assessed treatment outcomes of children with WT treated at a large Kenyan teaching and referral hospital.Design/methodsWe conducted a retrospective record review of children diagnosed with WT between 2013 and 2016. Treatment protocol consisted of 6 weeks of preoperative chemotherapy and surgery, and 4–18 weeks of postoperative chemotherapy depending on disease stage. Probability of event‐free survival (pEFS) and overall survival (pOS) was assessed using Kaplan–Meier method with Cox regression analysis. Competing events were analyzed with cumulative incidences and Fine–Gray regression analysis.ResultsOf the 92 diagnosed patients, 69% presented with high‐stage disease. Two‐year observed EFS and OS were, respectively, 43.5% and 67%. Twenty‐seven percent of children died, 19% abandoned treatment, and 11% suffered from progressive or relapsed disease. Patients who were diagnosed in 2015–2016 compared to 2013–2014 showed higher pEFS. They less often had progressive or relapsed disease (p = .015) and borderline significant less often abandonment of treatment (p = .09). Twenty‐nine children received radiotherapy, and 2‐year pEFS in this group was 86%.ConclusionOutcome of children with WT improved over the years despite advanced stage at presentation. Survival probabilities of patients receiving comprehensive therapy including radiation are approaching those of patients in high‐income countries. Additional improvement could be achieved by ensuring that patients receive all required treatment and working on earlier diagnosis strategies.
Prenatal work‐up, associated anomalies and postnatal outcomes of foetuses with 9–9.9 mm cerebral ventricular atria width
Authors: Sharon‐Weiner Maya , Gluska Hadar , Farladansky‐Gershnabel Sivan , Schreiber Hanoch , Biron‐Shental Tal , Markovitch Ofer 
Published: December 2021

AbstractObjectiveTo analyse prenatal work‐up, associated anomalies and postnatal outcomes of foetuses with cerebral lateral ventricular width 9–9.9 mm.MethodThis retrospective, observational, case‐control study included 121 foetuses with initial presentation of isolated cerebral lateral ventricular width 9–9.9 mm detected during routine ultrasound scans, 21–24 weeks' gestation, in a tertiary referral centre, January 2001–December 2018. Controls included 123 foetuses with lateral ventricular width <9 mm measured under the same parameters. Clinical characteristics, obstetrical history, ultrasound findings, prenatal work‐up and pregnancy outcomes were collected from medical records. Information about postnatal functional and neurodevelopmental sequelae were obtained from telephone‐based questionnaires.ResultsThe study group had more males (82/116 (70.6%) versus 65/123 (52.8%), p = 0.004), more prenatal testing, including brain magnetic resonance imaging (28/116 (24.1%) versus 0/123 (0%), p < 0.001), echocardiography (46/116 (39.7%) versus 15/123 (12.2%), p < 0.001) and targeted anomaly scans (102/116 (87.9%) versus 1/123 (0.008%), p < 0.001). Long‐term follow‐up did not reveal more neurodevelopmental sequelae compared to controls. Gender‐based analysis found more males with ventricular dilatation 9–9.9 mm treated for developmental delay compared to females with similar findings (15/82 (18.2%) versus 1/34 (2.9%), p = 0.010).ConclusionFoetuses with 9–9.9 mm cerebral lateral ventricular width versus <9 mm underwent more prenatal testing but had similar rates of neurodevelopmental sequelae.
Validity of self‐reports of medication treatment of depression in general population surveys
Authors: Mojtabai Ramin , Amin‐Esmaeili Masoumeh 
Published: December 2021

AbstractPurposeTo assess the concurrent validity of a single question on medication use for depression in a general population survey.MethodsUsing data from 2015 to 2016 and 2017 to 2018 National Health and Nutrition Examination Survey, we compared responses to a single question on medication use for depression with responses to a detailed questionnaire confirmed by inspecting medication packages or pharmacy printouts.ResultsThere was a strong agreement (96.4%) between response to a single question about using medication for depression and responses to questions about using antidepressants or other psychiatric medications for depression on the detailed questionnaire. The single‐question assessment had excellent sensitivity (93.8%) and specificity (96.7%), positive predictive value (71.5%), and kappa (0.79). Psychometric properties were mostly consistent across population subgroups.ConclusionsSingle‐question assessments of medication use for depression have acceptable concurrent validity against more detailed assessments and provide an efficient method for assessing medication treatment of depression in population health surveys.
High‐throughput cell‐free screening of eukaryotic membrane protein expression in lipidic mimetics
Authors: Bruni Renato , Laguerre Aisha , Kaminska Anna‐Maria , McSweeney Sean , Hendrickson Wayne A. , Liu Qun 
Published: December 2021

AbstractMembrane proteins play essential roles in cellular function and metabolism. Nonetheless, biophysical and structural studies of membrane proteins are impeded by the difficulty of their expression in and purification from heterologous cell‐based systems. As an alternative to these cell‐based systems, cell‐free protein synthesis has proven to be an exquisite method for screening membrane protein targets in a variety of lipidic mimetics. Here we report a high‐throughput screening workflow and apply it to screen 61 eukaryotic membrane protein targets. For each target, we tested its expression in lipidic mimetics: two detergents, two liposomes, and two nanodiscs. We show that 35 membrane proteins (57%) can be expressed in a soluble fraction in at least one of the mimetics with the two detergents performing significantly better than nanodiscs and liposomes, in that order. Using the established cell‐free workflow, we studied the production and biophysical assays for mitochondrial pyruvate carrier (MPC) complexes. Our studies show that the complexes produced in cell‐free are functionally competent in complex formation and substrate binding. Our results highlight the utility of using cell‐free systems for screening and production of eukaryotic membrane proteins.
Improved hospitalization rates in a specialty center for heart failure with preserved ejection fraction and pulmonary hypertension
Authors: Kosanovich Chad M. , Pi Hongyang , Handen Adam , Schikowski Erin , Chen Yimin , Thoma Floyd W. , Mulukutla Suresh , Koscumb Steve , Nouraie Mehdi , Chan Stephen Y. 
Published: December 2021

AbstractHeart failure with preserved ejection fraction can be complicated by pulmonary hypertension. We designed a retrospective study to provide supporting evidence for referral to specialty care centers. Specialty care centers improved hospitalizations but not mortality—in part due to more aggressive medication management and guideline‐directed monitoring.
Inflammatory pseudotumor mimicking chronic pulmonary embolism or pulmonary artery sarcoma: Report of five cases
Authors: Liao Xiaoyan , Bojanowski Christine M. , Yen Andrew , Kerr Kim M. , Dumouchel Justin , Auger William R. , Madani Michael M. , Pretorius Victor , Wang Huan‐You , Yi Eunhee S. , Lin Grace Y. 
Published: December 2021

AbstractInflammatory pseudotumor (IPT), also known as plasma cell granuloma, is a rare lesion of unknown etiology that occurs in many organs, especially in the lung. Here we report five cases of IPT arising in pulmonary artery mimicking chronic thromboembolic disease, not previously documented in the literature. Those cases were identified at our institute among over 2500 pulmonary endarterectomy (PEA) specimens acquired from 2000 to 2017. The cohort included three men and two women with a median age of 41 years (range: 23–54). All patients presented with dyspnea and radiologic findings of pulmonary artery thromboembolism, some concerning for intimal sarcoma. The duration between disease onset and PEA ranged from 6 months to approximately 3 years. Histologically, all cases showed proliferation of spindle cells with marked inflammatory infiltrates composed predominantly of plasma cells, histiocytes, and small lymphocytes. Ancillary studies were performed in each case and ruled out other possibilities, such as sarcoma, lymphoma, plasmacytoma, IgG4‐related disease, and infection. IPT arising in pulmonary artery presenting clinically as acute or chronic thromboembolic disease is very unusual, in which clinical data, radiographic findings, and histopathologic features have to be integrated for reaching the proper diagnosis.
A novel single composite Shewhart‐EWMA control chart for monitoring the process mean
Authors: Malela‐Majika Jean‐Claude , Shongwe Sandile C. , Castagliola Philippe , Mutambayi Ruffin M. 
Published: December 2021

AbstractStatistical process monitoring (SPM) literature recommends the combination of Shewhart and exponentially weighted moving average (EWMA) schemes to improve the ability of the standalone Shewhart and EWMA monitoring schemes in detecting small to large shifts. The resulting scheme is named combined (or composite) Shewhart‐EWMA (CSEWMA) scheme. In this paper, a new single composite Shewhart‐EWMA (denoted as SCSEWMA) scheme for monitoring the mean when the process parameters are known or unknown is proposed using an additive weighted model. The flexibility of the proposed scheme is made possible by an additional weighing parameter that regulates its sensitivity towards shifts of different sizes. The new scheme is compared to the existing Shewhart, EWMA and CSEWMA schemes, and the results reveal the superiority of the proposed scheme over the latter schemes. Simulated and real‐life data are used to demonstrate the application and implementation of the proposed scheme.
On the line shape of the total rovibronic absorption in laser‐dressed diatomic molecules
Authors: Halász Gábor J. , Szidarovszky Tamás , Vibók Ágnes 
Published: December 2021

AbstractRecently, the rovibronic absorption and emission spectra of diatomic molecules dressed by medium‐intensity laser fields have been discussed. By computing the total absorption probability as a function of dressing wavelength an asymmetric line shape has been obtained strongly resembling to the well‐known Fano line shape. Applying two‐state analytical and three‐state numerical models the shape of the total absorption probability function is explained. Further confirmation of the model based results is provided by high resolution accurate numerical computations using large number of basis functions.
Lingual Raynaud's phenomenon in a patient with mixed connective tissue disease
Authors: Gilbert Emily L. 
Published: December 2021

Key points

Raynaud's phenomenon may occur as a primary problem or secondary to an autoimmune disease such as scleroderma, mixed connective tissue disease, SLE, or Sjogren's.
Lingual Raynaud's is rare, but it is important to recognize as it is often attributed to autoimmune disease.
There is a wide range of symptoms in lingual Raynaud's from asymptomatic to severe, throbbing pain. Meticulous history taking is essential.
Electroless Deposition to Fabricate Radiation Protection Suits for Pregnant Women: Effect of Water Bath Temperature on the Electromagnetic Shielding Performance
Authors: Liu Wenya , Sun Di , Ma Haodong , Huang Junjun , Chen Zhenming , Gui Chengmei 
Published: December 2021

AbstractElectroless plating (EP) has great potential application in fabricating low‐cost metallized material. Here, EP‐Ni on cotton surface to fabricate radiation protection suits for pregnant women was established. The cotton fiber could absorb Sn, Pd particles and acted as catalytic center for EP‐Ni. Ni particle with (111) crystal plane preferential oriented crystal structure deposited on cotton surface with a coarse microstructure. The fabricated material exhibited an shielding effectiveness of 29.5 dB. Studies also shown that higher bath temperature would facilitate the enhancement of the crystallinity, electrical and electromagnetic shielding performance by 7 %, and the maximum cleaning temperature could reach 80 °C.
Design and Synthesis of Hydrazone‐Bearing Benzenesulfonamides as Carbonic Anhydrase VB Inhibitors
Authors: Urbelytė Liucija , Bagdonas Martynas , Grybaitė Birutė , Vaickelionienė Rita , Mickevičiūtė Aurelija , Michailovienė Vilma , Matulis Daumantas , Mickevičius Vytautas , Zubrienė Asta 
Published: December 2021

AbstractThe α‐amino acid derivatives are constituents of many bioactive compounds and display a wide variety of biological activities. We have synthesized a series of new benzenesulfonamide derivatives bearing α‐amino acid moiety at para‐position and evaluated their binding affinity to human carbonic anhydrase isozymes by fluorescent thermal shift assay. The dichloro‐ and monobromo‐substitutions on the benzenesulfonamide ring have been introduced to determine the halogenation effect on the binding affinity. Chloro substituents at 3,5‐positions of benzenesulfonamide derivatives increased the affinity for all carbonic anhydrases as compared to non‐chlorinated compounds. The hydrazone‐bearing 3,5‐dichlorobenzenesulfonamides 9 a, 9 d, and 12 exhibited a low nanomolar affinity for CA VB (Kd in the range of 6.6–8.1 nM), an isozyme implicated in diseases of the central nervous system and obesity.
Photoresponsive Solid Nanochannels Membranes: Design and Applications
Authors: Cheng Shi‐Qi , Zhang Si‐Yun , Min Xue‐Hong , Tao Ming‐Jie , Han Xiao‐Le , Sun Yue , Liu Yi 
Published: December 2021

AbstractLight stimuli have notable advantages over other environmental stimuli, such as more precise spatial and temporal regulation, and the ability to serve as an energy source to power the system. In nature, photoresponsive nanochannels are important components of organisms, with examples including the rhodopsin channels in optic nerve cells and photoresponsive protein channels in the photosynthesis system of plants. Inspired by biological channels, scientists have constructed various photoresponsive, smart solid‐state nanochannels membranes for a range of applications. In this review, the methods and applications of photosensitive nanochannels membranes are summarized. The authors believe that this review will inspire researchers to further develop multifunctional artificial nanochannels for applications in the fields of biosensors, stimuli‐responsive smart devices, and nanofluidic devices, among others.
MOF‐Enabled Ion‐Regulating Gel Electrolyte for Long‐Cycling Lithium Metal Batteries Under High Voltage
Authors: Fu Xuewei , Hurlock Matthew J. , Ding Chenfeng , Li Xiaoyu , Zhang Qiang , Zhong Wei‐Hong 
Published: December 2021

AbstractHigh‐voltage lithium metal batteries (LMBs) are a promising high‐energy‐density energy storage system. However, their practical implementations are impeded by short lifespan due to uncontrolled lithium dendrite growth, narrow electrochemical stability window, and safety concerns of liquid electrolytes. Here, a porous composite aerogel is reported as the gel electrolyte (GE) matrix, made of metal–organic framework (MOF)@bacterial cellulose (BC), to enable long‐life LMBs under high voltage. The effectiveness of suppressing dendrite growth is achieved by regulating ion deposition and facilitating ion conduction. Specifically, two hierarchical mesoporous Zr‐based MOFs with different organic linkers, that is, UiO‐66 and NH2‐UiO‐66, are embedded into BC aerogel skeletons. The results indicate that NH2‐UiO‐66 with anionphilic linkers is more effective in increasing the Li+ transference number; the intermolecular interactions between BC and NH2‐UiO‐66 markedly increase the electrochemical stability. The resulting GE shows high ionic conductivity (≈1 mS cm−1), high Li+ transference number (0.82), wide electrochemical stability window (4.9 V), and excellent thermal stability. Incorporating this GE in a symmetrical Li cell successfully prolongs the cycle life to 1200 h. Paired with the Ni‐rich LiNiCoAlO2 (Ni: Co: Al = 8.15:1.5:0.35, NCA) cathode, the NH2‐UiO‐66@BC GE significantly improves the capacity, rate performance, and cycle stability, manifesting its feasibility to operate under high voltage.
Mapping Conductance and Switching Behavior of Graphene Devices In Situ
Authors: Dyck Ondrej , Swett Jacob L. , Evangeli Charalambos , Lupini Andrew R. , Mol Jan A. , Jesse Stephen 
Published: December 2021

AbstractGraphene is proposed for use in various nanodevice designs, many of which harness emergent quantum properties for device functionality. However, visualization, measurement, and manipulation become nontrivial at nanometer and atomic scales, representing a significant challenge for device fabrication, characterization, and optimization at length scales where quantum effects emerge. Here, proof of principle results at the crossroads between 2D nanoelectronic devices, e‐beam‐induced modulation, and imaging with secondary electron e‐beam induced currents (SEEBIC) is presented. A device platform compatible with scanning transmission electron microscopy investigations is introduced. Then how the SEEBIC imaging technique can be used to visualize conductance and connectivity in single layer graphene nanodevices, even while supported on a thicker substrate (conditions under which conventional imaging fails) is shown. Finally, it is shown that the SEEBIC imaging technique can detect subtle differences in charge transport through time in nonohmic graphene nanoconstrictions indicating the potential to reveal dynamic electronic processes.