bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualifying quantum approaches for hard industrial optimization problems. A case study in the field of smart-charging of electric vehicles
Authors: Dalyac Constantin , Henriet Loïc , Jeandel Emmanuel , Lechner Wolfgang , Perdrix Simon , Porcheron Marc , Veshchezerova Margarita 
Published: May 2021

AbstractIn order to qualify quantum algorithms for industrial NP-Hard problems, comparing them to available polynomial approximate classical algorithms and not only to exact exponential ones is necessary. This is a great challenge as, in many cases, bounds on the reachable approximation ratios exist according to some highly-trusted conjectures of Complexity Theory. An interesting setup for such qualification is thus to focus on particular instances of these problems known to be “less difficult” than the worst-case ones and for which the above bounds can be outperformed: quantum algorithms should perform at least as well as the conventional approximate ones on these instances, up to very large sizes. We present a case study of such a protocol for two industrial problems drawn from the strongly developing field of smart-charging of electric vehicles. Tailored implementations of the Quantum Approximate Optimization Algorithm (QAOA) have been developed for both problems, and tested numerically with classical resources either by emulation of Pasqal’s Rydberg atom based quantum device or using Atos Quantum Learning Machine. In both cases, quantum algorithms exhibit the same approximation ratios as conventional approximation algorithms or improve them. These are very encouraging results, although still for instances of limited size as allowed by studies on classical computing resources. The next step will be to confirm them on larger instances, on actual devices, and for more complex versions of the problems addressed.
Belt and Road in Ethiopia and China’s African Ambition
Authors: Larçon Jean-Paul , Vadcar Corinne 
Published: May 2021

China–Ethiopia economic cooperation in the period of 2000–2020 is marked by the convergence between the industrial policy of Ethiopia, the orientations of the Forum on China–Africa Cooperation (FOCAC), and the infrastructure development strategy which is the cornerstone of China’s Belt and Road Initiative (BRI). China, the largest foreign investor in Ethiopia during this period, has had a major role in terms of investment and financing in the energy sector and the transportation infrastructure: Addis Ababa Airport, roads, railway, seaport terminal, and gas pipeline. The flagship project — the Addis Ababa–Djibouti Railway — connecting Addis Ababa to Djibouti City and Djibouti’s Doraleh Container Terminal, inaugurated in 2018, provided landlocked Ethiopia with a good connection between the hinterland and the seaport: the economic corridor accounts for more than 95% of Ethiopia’s foreign trade. The development of Ethiopian Industrial Parks on the model of Chinese Special Economic Zones (SEZs) was the second pillar of the strategy of development of an export-oriented manufacturing sector. Chinese companies operating in Ethiopian Industrial Parks in the textile and leather industries have been pioneering this activity contributing to Ethiopia’s participation in the Global Value Chains (GVCs). Ethiopian government is also planning the development of agro-industrial parks specialized in added-value agricultural products such as coffee or cut flowers exported to Europe via Addis Ababa Airport and Ethiopian Airlines Cargo. Ethiopia’s main challenges in that direction are the necessity to go up the value chain to further penetrate European markets and, most likely, to identify the products or services which could be integrated into the African markets in the new context of the African Continental Free Trade Area (AfCFTA) agreement that entered into force in January 2021.
The subantarctic lithospheric mantle
Authors: Delpech Guillaume , Scott James M. , Grégoire Michel , Moine Bertrand N. , Li Dongxu , Liu Jingao , Pearson D. Graham , van der Meer Quinten H. A. , Waight Tod E. , Michon Gilbert , Guillaume Damien , O'Reilly Suzanne Y. , Cottin Jean-Yves , Giret André 
Published: May 2021

Abstract
We present a summary of peridotite in the Subantarctic (46–60° S) surrounding the Antarctic Plate. Peridotite xenoliths occur on the Kerguelen Islands and Auckland Islands. The Kerguelen Islands are underlain by a plume, whereas the Auckland Islands are part of continental Zealandia, which is a Gondwana-rifted fragment. Small amounts of serpentinized peridotite has been dredged from fracture zones on the Southeast Indian Ridge, Southwest Indian Ridge and Pacific Antarctic Ridge, and represent upwelled asthenosphere accreted to form lithosphere. Suprasubduction-zone peridotite was collected from two locations on the Sandwich Plate. Peridotites from most subantarctic occurrences are moderately to highly depleted, and many show signs of subsequent metasomatic enrichment. Os isotopes indicate that subantarctic continental and oceanic lithospheric mantle contains ancient fragments that underwent depletion long before formation of the overlying crust.
Ogilvie Platform Composite Tectono-Sedimentary Element
Authors: Morrow David W. 
Published: May 2021

Abstract

The Ogilvie Platform Composite Tectono-Sedimentary Element (CTSE) occupies an area of about 68 000 km
2
in the northern part of the Yukon Territory of Canada, and includes all Paleozoic- and Triassic-aged strata between a base of Cambrian unconformity and a base of Jurassic and Cretaceous unconformity. This cratonic platform is composed of two lithologically distinct sedimentary successions: a lower suite of peritidal to shallow-subtidal, carbonate-dominated, Cambrian–Middle Devonian-aged units; and an upper succession of siliciclastic-dominated alluvial fan, shelf delta, nearshore, slope and basinal strata of Middle Devonian–Late Permian and Triassic age. The lower succession is composed of a synrift tectono-sedimentary element (TSE) and an overlying passive continental-margin TSE. The upper succession is composed of an Ellesmerian orogenic foreland TSE and a syn-epeirogenic TSE. The total discovered oil reserve within the Ogilvie Platform is estimated to be 1.757 × 10
6
m
3
(11.05 MMbbl) and the total discovered gas reserve is estimated to be 2.376 × 109 m
3
(83.7 Bcf) in four oil and gas pools. A variety of stratigraphic and structural trap types have been assessed to contain additional conventional hydrocarbon reserves, with a total mean potential of 33.4 × 10
6
m
3
(210.1 MMbbl) of oil and 33.4 × 10
9
m
3
(2.63 Tcf) of gas. The organic-rich shale and siltstone-dominated petroleum source-rock units, such as within the Road River Group, the Canol and Ford Lake formations, and organic-rich strata within the Hart River and Blackie formations, are also prospective for large reserves of unconventional oil and gas, and have yet to be formally assessed.
Petrogenesis of silicic rocks from the Phan Si Pan–Tu Le region of the Emeishan large igneous province, northwestern Vietnam
Authors: Pham Thuy Thanh , Shellnutt J. Gregory , Tran Tuan-Anh , Denyszyn Steven W. , Iizuka Yoshiyuki 
Published: May 2021

Abstract

The Permian silicic rocks in the Phan Si Pan (PSP) Uplift area and Tu Le (TL) basin of NW Vietnam (collectively the PSP–TL region) are associated with the Emeishan large igneous province (ELIP). The Permian Muong Hum, Phu Sa Phin and Nam Xe–Tam Duong granites and Tu Le rhyolites are alkali ferroan A
1
-type granitic rocks, which probably formed by fractional crystallization of high-Ti basaltic magma that was contaminated by melts derived from the Neoproterozoic host rocks. Zircon U–Pb laser ablation inductively coupled plasma mass spectrometry (LA–ICP–MS) geochronology yielded weighted-mean
206
Pb/
238
U ages of 246 ± 3 to 259 ± 3 Ma for granites, and 249 ± 3 and 254 ± 2 Ma for rhyolites. This is contrasted with previously published high precision U–Pb ages, obtained using chemical abrasion–isotope dilution–thermal ionization mass spectrometry method applied on the same zircon grains, which suggests that the calculated LA–ICP–MS U–Pb ages are variably inaccurate by up to 10 Ma, although at the single-grain level dates generally agree within uncertainty. The similarity of rock texture, whole-rock geochemistry, emplacement ages and fractionation phases between the PSP–TL region and silicic rocks in the Inner Zone ELIP (i.e. Panzhihua, Binchuan) suggests they were spatially proximal before being sinistrally displaced along the Ailao Shan–Red River shear zone.
Petrogenesis and tectonic settings of Proterozoic mafic magmatism from the northern Indian Shield and the Himalaya: possible role for interaction of mantle plume with the subcontinental lithospheric mantle
Authors: Ahmad Talat , Yousuf Ibrahim , Chauhan Hiredya 
Published: May 2021

Abstract

Northern Indian Shield and the western Himalaya have an impressive record of mafic magmatism. The Aravalli Craton preserved 2.3 Ga komatiitic (picritic) and 2.1–1.8 Ga tholeiities. Gwalior and Betul belts preserved 2.1 and 1.5–1.2 Ga tholeiites, respectively. Western Himalaya has preserved 2.1–1.8 Ga tholeiites in Garhwal and Himachal regions. Studied rocks depict enriched rare earth elements, large ion lithophile elements and depleted high field strength elements. Whereas komatiites/picrites represent higher degrees of partial melting (
c.
35–40%) at higher temperatures (
c.
1500°C), tholeiites represent lower degrees of partial melting (
c.
10%) at lower temperatures (
c.
1200°C). Our results indicate interaction of mantle plume with variably enriched subcontinental lithospheric mantle sources, causing generation of these varied magmatic suites of rocks. Whereas the higher temperature komatiitic/picritic melts from the Aravalli region appear to have been generated closer to the plume head, the lower temperature tholeiitic melts from the shield region and western Himalaya were generated towards the plume margins. Different terrains of the study have undergone plume tectonics causing the development of the rift valleys. The majority of these developed into aulacogens, except for the Aravalli basin, which developed into deeper marine facies.
Combined Blockade of MEK and CDK4/6 Pathways Induces Senescence to Improve Survival in Pancreatic Ductal Adenocarcinoma
Authors: Willobee Brent A. , Gaidarski Alexander A. , Dosch Austin R. , Castellanos Jason A. , Dai Xizi , Mehra Siddharth , Messaggio Fanuel , Srinivasan Supriya , VanSaun Michael N. , Nagathihalli Nagaraj S. , Merchant Nipun B. 
Published: May 2021

Abstract
Activating KRAS mutations, a defining feature of pancreatic ductal adenocarcinoma (PDAC), promote tumor growth in part through the activation of cyclin-dependent kinases (CDK) that induce cell-cycle progression. p16INK4a (p16), encoded by the gene CDKN2A, is a potent inhibitor of CDK4/6 and serves as a critical checkpoint of cell proliferation. Mutations in and subsequent loss of the p16 gene occur in PDAC at a rate higher than that reported in any other tumor type and results in Rb inactivation and unrestricted cellular growth. Therefore, strategies targeting downstream RAS pathway effectors combined with CDK4/6 inhibition (CDK4/6i) may have the potential to improve outcomes in this disease. Herein, we show that expression of p16 is markedly reduced in PDAC tumors compared with normal pancreatic or pre-neoplastic tissues. Combined MEK inhibition (MEKi) and CDK4/6i results in sustained downregulation of both ERK and Rb phosphorylation and a significant reduction in cell proliferation compared with monotherapy in human PDAC cells. MEKi with CDK4/6i reduces tumor cell proliferation by promoting senescence-mediated growth arrest, independent of apoptosis in vitro. We show that combined MEKi and CDK4/6i treatment attenuates tumor growth in xenograft models of PDAC and improves overall survival over 200% compared with treatment with vehicle or individual agents alone in Ptf1acre/+;LSL-KRASG12D/+;Tgfbr2flox/flox (PKT) mice. Histologic analysis of PKT tumor lysates reveal a significant decrease in markers of cell proliferation and an increase in senescence-associated markers without any significant change in apoptosis. These results demonstrate that combined targeting of both MEK and CDK4/6 represents a novel therapeutic strategy to synergistically reduce tumor growth through induction of cellular senescence in PDAC.
Automated Left Ventricular Dimension Assessment Using Artificial Intelligence Developed and Validated by a UK-Wide Collaborative
Authors: Howard James P. , Stowell Catherine C. , Cole Graham D. , Ananthan Kajaluxy , Demetrescu Camelia D. , Pearce Keith , Rajani Ronak , Sehmi Jobanpreet , Vimalesvaran Kavitha , Kanaganayagam G. Sunthar , McPhail Eleanor , Ghosh Arjun K. , Chambers John B. , Singh Amar P. , Zolgharni Massoud , Rana Bushra , Francis Darrel P. , Shun-Shin Matthew J. 
Published: May 2021

Background:
Artificial intelligence (AI) for echocardiography requires training and validation to standards expected of humans. We developed an online platform and established the Unity Collaborative to build a dataset of expertise from 17 hospitals for training, validation, and standardization of such techniques.

Methods:
The training dataset consisted of 2056 individual frames drawn at random from 1265 parasternal long-axis video-loops of patients undergoing clinical echocardiography in 2015 to 2016. Nine experts labeled these images using our online platform. From this, we trained a convolutional neural network to identify keypoints. Subsequently, 13 experts labeled a validation dataset of the end-systolic and end-diastolic frame from 100 new video-loops, twice each. The 26-opinion consensus was used as the reference standard. The primary outcome was precision SD, the SD of the differences between AI measurement and expert consensus.

Results:
In the validation dataset, the AI’s precision SD for left ventricular internal dimension was 3.5 mm. For context, precision SD of individual expert measurements against the expert consensus was 4.4 mm. Intraclass correlation coefficient between AI and expert consensus was 0.926 (95% CI, 0.904–0.944), compared with 0.817 (0.778–0.954) between individual experts and expert consensus. For interventricular septum thickness, precision SD was 1.8 mm for AI (intraclass correlation coefficient, 0.809; 0.729–0.967), versus 2.0 mm for individuals (intraclass correlation coefficient, 0.641; 0.568–0.716). For posterior wall thickness, precision SD was 1.4 mm for AI (intraclass correlation coefficient, 0.535 [95% CI, 0.379–0.661]), versus 2.2 mm for individuals (0.366 [0.288–0.462]). We present all images and annotations. This highlights challenging cases, including poor image quality and tapered ventricles.

Conclusions:
Experts at multiple institutions successfully cooperated to build a collaborative AI. This performed as well as individual experts. Future echocardiographic AI research should use a consensus of experts as a reference. Our collaborative welcomes new partners who share our commitment to publish all methods, code, annotations, and results openly.
Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis
Authors: Watanabe Hirofumi , Belyea Brian C. , Paxton Robert L. , Li Minghong , Dzamba Bette J. , DeSimone Douglas W. , Gomez R. Ariel , Sequeira-Lopez Maria Luisa S. 
Published: May 2021

Rationale:
Renin-expressing cells are myoendocrine cells crucial for survival. They have been postulated to possess a pressure-sensing mechanism, a baroreceptor, which can detect slight changes in blood pressure and respond with precise and synchronized amounts of renin synthesized and released to the circulation to maintain blood pressure and fluid-electrolyte balance. The location and nature of this puzzling pressure-sensing structure have remained unknown as it was originally suggested over 60 years ago.

Objective:
To elucidate the location and structure of the renin cell baroreceptor.

Methods and Results:
We used a variety of genetically modified mice whereby renin cells were exposed in vivo to either low or high arterial pressure. In addition, we applied direct mechanical stimuli, that is, pneumatic pressure or stretch, directly to renin cells cultured under different conditions and substrata. Changes in perfusion pressure and/or direct mechanical stimuli induced significant changes in renin gene expression and the phenotype of renin cells. Importantly, the experiments show that the pressure-sensing mechanism (the baroreceptor) resides in the renin cells; it requires initial extracellular sensing by integrin β1 at the renin cell membrane and is transduced to the nuclear membrane and chromatin by lamin A/C.

Conclusions:
These studies show that the enigmatic baroreceptor is a nuclear mechanotransducer that resides in the renin cells per se and is responsible for the sensing and transmission of extracellular physical forces directly to the chromatin of renin cells via lamin A/C to regulate renin gene expression, renin bioavailability, and homeostasis.
Tracking the Atmospheric–Terrestrial Water Cycle over the Tibetan Plateau Based on ERA5 and GRACE
Authors: Lei Yonghui , Shi Jiancheng , Xiong Chuan , Ji Dabin 
Published: May 2021

AbstractIn this study, the net water flux (precipitation minus evaporation) over the Tibetan Plateau (TP) and its 12 drainage basins is estimated using ERA5. The terrestrial branch of the water cycle is investigated using the total water storage anomalies (TWSAs) derived from GRACE (Gravity Recovery and Climate Experiment) data and daily streamflow records collected in Zhimenda and Tangnaihai (two hydrological stations located in the upper Yangtze River Basin and upper Yellow River Basin). This work provides a preliminary assessment of discrepancies between model-derived and space-based observations in the atmospheric–terrestrial water cycle over the TP and its drainage basins. The results show that the net water fluxes occurring over the TP and the scale of its drainage basins are closely tied to local dynamics and physical processes and to large-scale circulation and atmospheric water vapor. ERA5 maintains the atmospheric water balance over the TP. ERA5-derived net water flux anomalies constitute a major component of the water cycle and correspond to GRACE-derived TWSAs. The water budget–based approach with the ERA5 and ITSG-Grace2018 datasets constrains the atmospheric–terrestrial water cycle over the TP and its drainage basins. Both the ERA5- and GRACE-derived estimates contain consistent long- and short-term variations over the TP. Discrepancies are evident at the drainage basin, while the ratio of signal to noise in both the ERA5 and GRACE datasets might cause discrepancies between estimates over relatively small or arid basins. Nevertheless, the observed good correspondence between ERA5- and GRACE-derived atmospheric–terrestrial water cycles over the TP highlights the potential value of the rational application of water resource information.
The relationship between the polar jet stream and extreme wildfire events in North America
Authors: Jain Piyush , Flannigan Mike 
Published: May 2021

AbstractNorthern hemisphere mid-latitudeweather is strongly influenced by the polar jet stream (PJS), which dictates the position of storm tracks; this influence also extends to weather patterns conducive to the ignition and growth of large wildfires. We examined the role of the PJS on extreme wildfire events in North America (NA) between 40° and 70°N latitude, using fire spread events (FSEs) for 2002—2016. Climatologies of the 300-hPa wind components and derived quantities show that the PJS weakens and moves northward in the Boreal summer coincident with the fire season. We use spatio-temporal compositing of 300-hPa winds and 500-hPa geopotential height anomalies to show that FSEs are associated with an upper-level ridge and high centered over events, except eastern Canada where patterns are displaced westward. Ridge patterns persist longer for FSEs in western NA compared with Eastern NA, as well as for May to August compared with April, September and October. These tropospheric patterns also occur concomitantly with surface weather drivers of fire spread including positive daily mean temperature and vapor pressure deficit anomalies and negative precipitation anomalies. Distributions of maximum and minimum latitudinal jet stream peak, ridge and trough positions, relative to FSEs, confirm that events occur predominantly southward of the jet stream core and near a ridge for low split flow configurations but not necessarily for high split flow configurations. These findings have wide-reaching implications for better understanding NA fire regimes and potential fire management strategies (eg. resource pre-positioning and tactical suppression) through improved forecasting of fire weather.
Future Changes to El Niño Teleconnections over the North Pacific and North America
Authors: Beverley Jonathan D. , Collins Matthew , Lambert F. Hugo , Chadwick Robin 
Published: May 2021

AbstractThe El Niño-Southern Oscillation (ENSO) is the leading mode of interannual climate variability and it exerts a strong influence on many remote regions of the world, for example in northern North America. Here, we examine future changes to the positive-phase ENSO teleconnection to the North Pacific/North America sector and investigate the mechanisms involved. We find that the positive temperature anomalies over Alaska and northern North America that are associated with an El Niño event in the present day are much weaker, or of the opposite sign, in the CMIP6 abrupt 4×CO2 experiments for almost all models (22 out of 26, of which 15 are statistically significant differences). This is largely related to changes to the anomalous circulation over the North Pacific, rather than differences in the equator-to-pole temperature gradient. Using a barotropic model, run with different background circulation basic states and Rossby wave source forcing patterns from the individual CMIP6 models, we find that changes to the forcing from the equatorial central Pacific precipitation anomalies are more important than changes in the global basic state background circulation. By further decomposing this forcing change into changes associated with the longitude and magnitude of ENSO precipitation anomalies, we demonstrate that the projected overall eastward shift of ENSO precipitation is the main driver of the temperature teleconnection change, rather than the increase in magnitude of El Niño precipitation anomalies which are, nevertheless, seen in the majority of models.
Analysis of the Antarctic Ozone Hole in November
Authors: WANG ZHE , ZHANG JIANKAI , WANG TAO , FENG WUHU , HU YIHANG , XU XIRAN 
Published: May 2021

AbstractThe factors responsible for the size of Antarctic ozone hole in November are analyzed. Comparing two samples of anomalously large and small November ozone hole with respect to 1980–2017 climatology in November, the results show that the anomalously large ozone hole in austral late winter is not a precondition for the anomalously large ozone hole in November. The size of Antarctic ozone hole in November is mainly influenced by dynamical processes from the end of October to mid-November. During large November ozone hole events, weaker dynamical ozone transport appears from the end of October to mid-November, which is closely related to planetary wave divergence in the stratosphere between 60°S and 90°S. Further analyses indicate that the wave divergence is partially attributed to less upward propagation of planetary waves from the troposphere, which is associated with weak baroclinic disturbances at the end of October. Subsequently, zonal wind speed in the upper stratosphere intensifies, and the distance between critical layer (U=0) and wave reflecting surfaces becomes larger. As a result, more planetary waves are reflected and then wave divergence enhances. The processes responsible for the anomalously small Antarctic ozone holes in November are almost opposite to those for the anomalously large Antarctic ozone holes.