bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Graft Weight Change During Perfusion on Hepatocellular Carcinoma Recurrence After Living Donor Liver Transplantation
Authors: Kim Jong Man , Chung Young Jae , Kim Sangjin , Rhu Jinsoo , Choi Gyu-Seong , Joh Jae-Won 
Published: February 2021

BackgroundsInadequate liver volume and weight is a major source of morbidity and mortality after adult living donor liver transplantation (LDLT). The purpose of our study was to investigate HCC recurrence, graft failure, and patient survival according to change in right liver graft weight after histidine-tryptophan-ketoglutarate (HTK) solution perfusion in LDLT.MethodsTwo hundred twenty-eight patients underwent LDLT between 2013 and 2017. We calculated the change in graft weight by subtracting pre-perfusion graft weight from post-perfusion graft weight. Patients with increased graft weight were defined as the positive group, and patients with decreased graft weight were defined as the negative group.ResultsAfter excluding patients who did not meet study criteria, 148 patients underwent right or extended right hepatectomy. The negative group included 89 patients (60.1%), and the positive group included 59 patients (39.9%). Median graft weight change was -28 g (range; -132–0 g) in the negative group and 21 g (range; 1–63 g) in the positive group (P&lt;0.001). Median hospitalization time was longer for the positive group than the negative group (27 days vs. 23 days; P=0.048). There were no statistical differences in tumor characteristics, postoperative complications, early allograft dysfunction, or acute rejection between the two groups. Disease-free survival, death-censored graft survival, and patient survival were lower in the positive group than the negative group. Additionally, the positive group showed strong association with HCC recurrence, death-censored graft survival, and patient survival in multivariate analysis.ConclusionThis study suggests that positive graft weight change during HTK solution perfusion indicates poor prognosis in LDLT.
lncRNA MIR22HG-Derived miR-22-5p Enhances the Radiosensitivity of Hepatocellular Carcinoma by Increasing Histone Acetylation Through the Inhibition of HDAC2 Activity
Authors: Jin Qiao , Hu Hao , Yan Siqi , Jin Long , Pan Yuliang , Li Xiangjun , Peng Yayi , Cao Peiguo 
Published: February 2021

BackgroundWith the development of radiotherapy technology, radiotherapy has been increasingly used to treat primary hepatocellular carcinoma (HCC). However, due to radioresistance and the intolerance of the adjacent organs to radiation, the effects of radiotherapy are often unsatisfactory. Therefore, it is necessary to study radiosensitization in HCC.MethodA microarray was used to analyze the genes that were significantly associated with radiosensitivity. HCC cells, HepG2 and MHCC97H, were subjected to radiation in vitro. Real-time PCR was performed to determine MIR22HG (microRNA22 host gene) and miR-22-5p expression levels. Western blotting was performed to determine histone expression levels. A histone deacetylase (HDAC) whole cell assay was used to determine the activity of HDAC2. MTT, colony formation, 5-ethynyl-2′-deoxyuridine, and wound healing assays were performed to examine the function of MIR22HG and miR-22-5p in cellular radiosensitivity. Chromatin immunoprecipitation-PCR was used to confirm that HDAC2 affects the acetylation level of the MIR22HG promoter region. Finally, animal experiments were performed to demonstrate the in vivo effect of MIR22HG on the radiosensitivity of hepatoma.ResultsIrradiation can up-regulate MIR22HG expression and down-regulate HDAC2 expression. Inhibition of HDAC2 expression promotes histone acetylation in the MIR22HG promoter region and up-regulates MIR22HG expression. MIR22HG can increase radiosensitivity via miR-22-5p in HCC.ConclusionInhibition of HDAC2 expression promotes histone acetylation in the MIR22HG promoter region, thereby up-regulating the expression of MIR22HG and promoting the production of miR-22-5p, and ultimately increasing the sensitivity of liver cancer radiotherapy.
The Combination of Aquilaria sinensis (Lour.) Gilg and Aucklandia costus Falc. Volatile Oils Exerts Antidepressant Effects in a CUMS-Induced Rat Model by Regulating the HPA Axis and Levels of Neurotransmitters
Authors: Li Huiting , Li Yuanhui , Zhang Xiaofei , Ren Guilin , Wang Liangfeng , Li Jianzhe , Wang Mengxue , Ren Tao , Zhao Yi , Yang Ming , Huang Xiaoying 
Published: February 2021

The Aquilaria sinensis (Lour.) Gilg (CX)–Aucklandia costus Falc. (MX) herbal pair is frequently used in traditional Chinese medicine prescriptions for treating depression. The volatile oil from CX and MX has been shown to have good pharmacological activities on the central nervous system, but its curative effect and mechanism in the treatment of depression are unclear. Therefore, the antidepressant effect of the volatile oil from CX–MX (CMVO) was studied in chronic unpredictable mild stress (CUMS) rats. The suppressive effects of CMVO (25, 50, 100 μL/kg) against CUMS-induced depression-like behavior were evaluated using the forced swimming test (FST), open field test (OFT) and sucrose preference test (SPT). The results showed that CMVO exhibited an antidepressant effect, reversed the decreased sugar preference in the SPT and prolongation of immobility time in the FST induced by CUMS, increased the average speed, time to enter the central area, total moving distance, and enhanced the willingness of rats to explore the environment in the OFT. Inhalational administration of CMVO decreased levels of adrenocorticotropic hormone and corticosterone in serum and the expression of corticotropin-releasing hormone mRNA in the hypothalamus, which indicated regulation of over-activation of the hypothalamic–pituitary–adrenal (HPA) axis. In addition, CMVO restored levels of 5-hydroxytryptamine (5-HT), dopamine, norepinephrine and acetylcholine in the hippocampus. The RT-PCR and immunohistochemistry results showed that CMVO up-regulated the expression of 5-HT1A mRNA. This study demonstrated the antidepressant effect of CMVO in CUMS rats, which was possibly mediated via modulation of monoamine and cholinergic neurotransmitters and regulation of the HPA axis.
Predictive Value of the Age, Creatinine, and Ejection Fraction (ACEF) Score in Patients With Acute Fulminant Myocarditis
Authors: Liu Lin , Yang Xinyu , Gu Yiyu , Jiang Tingbo , Xu Jialiang , Xu Mingzhu 
Published: February 2021

ObjectivePatients with acute fulminant myocarditis often have more adverse cardiovascular events and higher mortality. The purpose of this study was to evaluate the usefulness of age, creatinine, and left ventricular ejection fraction (ACEF score), in determining the risk that acute fulminant myocarditis will lead to serious cardiovascular events, death, and cardiac dysfunction.MethodsWe retrospectively reviewed the demographics, laboratory tests, medications, echocardiographic examinations, in-hospital clinical outcomes, major adverse cardiovascular events (MACE), and survival rate at 1 year in the medical records of 220 consecutive subjects suffering from acute fulminant myocarditis from January 2013 to June 2019.ResultsTwo hundred twenty patients were divided into a survivor group and a non-survivor group. This study found that patients in the non-survivor group were older, had higher heart rates, and had more serious injuries to multiple organ functions. A high ACEF score at admission was independently associated with an unfavorable prognosis, and it was a predictor of in-hospital mortality. The current analysis extends the predictive performance of the ACEF scores at 30 days by evaluating echocardiographic data as applied to survivors of fulminant myocarditis and cumulative rates of MACE at 1 year. The results indicated that patients with high ACEF scores had poor recovery of cardiac function, and higher rates of MACE, all-cause death, and heart failure at 1 year than the low-ACEF group.ConclusionThe ACEF score was identified as an effective predictor of poor in-hospital outcomes, worse cardiac recovery after 30 days, and higher rates of MACE, all-cause death, and heart failure at 1 year in patients who had acute fulminant myocarditis. These data suggest that its predictive accuracy means the ACEF score could be used to assess the prognosis of patients with acute fulminant myocarditis.
The Impact of Matching to Psychotherapy Preference on Engagement in a Randomized Controlled Trial for Patients With Advanced Cancer
Authors: Marziliano Allison , Applebaum Allison , Moyer Anne , Pessin Hayley , Rosenfeld Barry , Breitbart William 
Published: February 2021

Objective: This study examined whether patients who were randomly assigned to their preferred therapy arm had stronger engagement with their treatment than those who were randomly assigned to a non-preferred therapy arm.Method: Data were drawn from a RCT comparing Individual Meaning-Centered Psychotherapy (IMCP), with Individual Supportive Psychotherapy (ISP), in patients with advanced cancer. Treatment engagement was operationalized as patients' perceptions of the therapeutic alliance with their therapist and therapy sessions attended. Two 2 by 2 Analysis of Variance (ANOVA) models were used, with treatment preference (IMCP vs. ISP) and treatment assignment (IMCP vs. ISP) as the independent variables and working alliance and number of sessions attended as outcome variables.Results: Patients who preferred and were assigned to IMCP reported a significantly stronger alliance than those who preferred IMCP but were assigned to ISP.Conclusions: The findings from this study have broader implications for research on psychotherapy beyond the appeal of IMCP in advanced cancer patients. Patients who prefer a novel psychotherapy that they cannot engage in elsewhere, but receive the standard treatment may experience weaker alliance than patients who prefer the standard but receive the novel therapy.Trial registration:Clinicaltrial.gov ID: NCT01323309
Analisis Faktor Yang Mempengaruhi Masyarakat Muslim Melakukan Wakaf Saham
Authors: Sahal Anwar 
Published: February 2021

Abstract: The purpose of this research is to analyze the factors of product knowledge, Islamic religiosity, consumer attitude, trust, intention, and consumer behavior that influencing Moslem societies in contributing to the waqf of shares. This research uses survey data from questionnaires which distributed to 220 respondents who live in areas of DKI Jakarta, Bogor, Depok, Tangerang, and Bekasi. Respondent data is processed using SEM analysis method which supported by Smart PLS application. The result of this research shows that the factors of product knowledge and trust are not significant influence on intention factor of Moslem societies in contributing on waqf of shares. Islamic religiosity and consumer attitude factors have positive and significant influence on intention factor. Meanwhile, intention factor has positive and very significant influence on consumer behavior factor with a statistic value of 22,963. Suggestions based on research result: first, it is necessary to hold a literacy and education program for Moslem societies in order to the understanding and knowledge of Moslem societies about waqf of shares are better. Second, it is necessary to hold a certification program for nazhir so that Moslem societies’ trust in nazhir increases.
Keywords: Moslem Societies, Intention, Waqf of Shares.
MODEL PENGEMBANGAN ISLAMIC MICROFINANCE BERBASIS KOPERASI SYARIAH (Studi Pada Pengrajin Mebeul Di Cipacing Kabupaten Sumedang)
Authors: Marlina Ropi , Nurhayati Ade 
Published: February 2021

Penelitian ini dasarkan pada fenomena masalah yang ada dalam UMKM khususnya industri mebeul. Permasalahan yang dimaksud meliputi, produk, SDM dan permodalan. Tujuan penelitian ini untuk memperolah sebuah model pengembangan mikrofinance yang bisa berkontribusi pada UMKM. Hasil penelitian menunjukkan bahwa koperasi syariah merupakan salah satu lembaga mikrofinance yang bisa diharapkan mampu menjadi solusi dalam mengatasi permasalahan khususnya pemodalan dalam UMKM mebeul di Cipacing. Dengan model akad mudharabah dan musyarakah koperasi syariah bisa dijadikan salah satu bentuk pembiaayan terhadap pelaku UMKM. Selain itu koperasi syariah sebagai wadah juga bisa dijadikan mitra untuk pengembangan UMKM mebel yang ada di daerah Cipacing Jawa Barat. Penelitian ini berimplikasi bahwa keberadaan Koperasi bisa dijadikan alternanif solusi oleh para pelaku UMKM mebel di daerah cipacing terutama dalam hal permodalan dan pemasaran.
Keywords : UMKM, Microfinance, Koperasi Syariah.
PERFIL DOS CRIADORES TRADICIONAIS DE CAPRINOS DO MUNICÍPIO DO NEGAGE, NA PROVÍNCIA DO UÍGE, EM ANGOLA
Authors: Afonso Pedro Roberto , Chiaia Hermenegildo Lucas Justino , Cordeiro José Manuel Moras , Gonzáles Mário Galvéz 
Published: February 2021

O objetivo deste trabalho foi caracterizar o perfil dos criadores tradicionais de caprinos do município do Negage, província do Uíge, Angola. Realizou-se inquérito aos criadores, mediante a elaboração de uma ficha para o registro dos dados de cada criador. Foram selecionados, aleatoriamente, 60 criadores em colaboração com o Instituto dos Serviços de Veterinária de Angola no Uíge. Os membros por família variaram entre 3 a 5 (25%), 6 a 8 (48%) e 9 a 12 (27%); o objetivo da criação dos caprinos variou entre comercial/troca (47%), investimento (45%) e consumo (8%). Do universo de inquiridos sobre a posse dos caprinos, 55% afirmaram que pertencem ao casal, 37% ao marido e 8% à esposa, sendo a responsabilidade dos caprinos assumida pelo marido (52%). A pastagem natural tem sido a base da alimentação em todas as criações de caprinos pesquisadas (100%). As condições higiênicas dos locais de exploração dos caprinos apresentavam-se como razoáveis (67%), más (18%) e boas (15%). Na sua maioria, os criadores não têm se beneficiado com formação técnica em caprinocultura (98%), nem recebem assistência veterinária e/ou zootécnica (97%). Além disso, eles têm dificuldades na aquisição de medicamentos veterinários (100%); e, parte dos criadores (60%), estaria disponível a pagar por assistência veterinária/zootécnica, sendo que todos os criadores mostraram interesse em receber formação profissional em caprinocultura. Por fim, quanto ao sistema de exploração dos caprinos na região do Negage, este foi considerado extensivo.
Can Zonulin level be a new diagnosis and follow-up criterion in active ulcerative colitis?
Authors: Akbaş Enver , Ülfer Gözde 
Published: February 2021

Objective: In this study, we compared the serum zonulin levels in patients diagnosed for the first time with active ulcerative colitis with those in healthy cases and attempted to determine whether serum zonulin levels were different in the active ulcerative colitis.
Material and Methods: A total of 53 naive patients admitted to our hospital between 2019 and 2020 and diagnosed with active ulcerative colitis by colonoscopy were included as a group of cases and 37 patients with no acute or chronic diseases whose colonoscopy was normal as the control group.
Results: The study was conducted on 90 cases, 65.5% male and 34.5% female. The patients with ulcerative colitis were compared with the control group in terms of serum zonulin levels. Average serum zonulin levels of the patients with ulcerative colitis (16.73 ± 5.49 ng/ml) were not significantly different than those in the control group 17.48 ± 8.31 ng/ml). Serum zonulin levels of the patients were also compared according to location and severity of disease and did not differ statistically significantly between the groups in terms of the Montreal Classification. When serum zonulin levels were grouped according to the Truelove and Witts criteria, there was no statistically significant difference between the patient groups themselves and the control group.
Conclusion: Serum zonulin levels were not greater in the patients with naive active ulcerative colitis compared to the healthy controls. Several previous studies have shown that serum zonulin levels are elevated in patients with ulcerative colitis, but more studies are needed on this subject.
DETERMINAN KEJADIAN IKTERUS NEONATORUM DI RS MUHAMMADIYAH SELOGIRI WONOGIRI
Authors: Ramadhany Nurul Fajar , Widodo Pratikto , Soleman Sanirahman 
Published: February 2021

Background . Neonatal jaundice is a clinical condition in infants characterized by jaundice staining on the skin and sclera due to excessive conjugated bilirubin buildup . This study aims to know the determinants of neonatal jaundice, include sex, type of birth, length of stay after birth, stimulation of early breastfeeding, formula feeding, fever after birth, amniotic color, birth weight, birth length, weight loss, gestational age, and APGAR scores at Muhammadiyah Selogiri Hospital, Wonogiri.
Method. This is a case control research using total sampling . Case criteria in this study were patients with a diagnosis of neonatal jaundice and control criteria who were not jaundice . The data were analyzed by chi square and analysis of multivariate with logistic regression.
Result. Based on multivariate analysis, length of stay (p value: 0.001; OR: 4.582), Early Initiation of Breastfeeding (p value: 0.002; OR: 5.146), Formula feeding (p value: 0.000; OR: 0.319), birth weight ( p value: 0,000; OR: 35,352), Body length (p value: 0.047; OR: 0.499), Weight loss (p value: 0,000; OR: 2.795), Apgar score (p value: 0,000; OR: 0.030) . Based on logistic regression analysis non-vaginal delivery (p value: 0.027; aOR: 7.372), normal body weight (p value: 0.000; aOR: 122.372 ), no asphyxia (p value: 0,000; aOR: 227,589 ).
Conclusion Infants who was born by non-vaginal delivery have risk of 7.372 times compared to vaginal delivery infants. Babies who were discharged < 3 days had a risk of 4.582 times greater. Early Initiation of Breastfeeding stimulation related to exclusive breastfeeding has a 5.146 times relationship to the incidence of Jaundice Breastmilk and Breastfeeding Jaundice jaundice . Normal infant weight is at a risk of 35,352 times related to the length of treatment after birth and the incidence of normal Jaundice. Weight loss in newborns is 2.795 times the risk of experiencing Breastmilk Jaundice and normal Jaundice.
UJI VALIDITAS SIRIRAJ STROKE SCORE, ALGORITMA STROKE GADJAH MADA, SKOR STROKE NUARTHA TERHADAP COMPUTERIZED TOMOGRAPHY SCAN KEPALA DALAM MENENTUKAN JENIS STROKE PADA FASE AKUT
Authors: Lestari Trisna , Artini Yuli , Noor Farida , Permanaputra Ariebuana , Ramadani Claranur 
Published: February 2021

Stroke is a syndrome that is characterized by sudden functional focal and global brain disorder that develops very quickly lasting more than 24 hours (unless there is surgical intervention or bringing death) caused by vascular disorder in the brain (Gofir, 2009). Stroke is the number one cause of serious disability settled worldwide. Stroke is also a leading cause of death worldwide. This research had 87 sample, consisting of 50 men and 37 women. The study was done using patient suspect stroke that enter the emergency room. The analysis result was nuartha’s stroke score has the highest sensitivity and specificity compared to Siriraj Stroke Score and Gadjah Mada Stroke Score. The sensitivity of the Nuartha Stroke Score in diagnosing non hemorrhagic stroke was 94,87 and with a specificity of 94.12%. Whereas for diagnosing hemorrhagic stroke, nuartha stroke score has a sensitivity of 94,12% and specificity of 94.87%. With an accuracy of 94.64%
PEMERIKSAAN RADIOLOGI GIANT BULLOUS LUNG DISEASE
Authors: Auzy F 
Published: February 2021

Giant bullous lung disease adalah suatu kondisi klinis yang ditandai oleh bullae berukuran besar yang volumenya cukup signifikan. Kriteria radiologi untuk kelainan tersebut adalah adanya giant bullae di satu atau kedua apeks paru, meliputi minimal sepertiga hemithorax dan mengkompresi parenkim paru normal di sekitarnya. Pada dewasa, faktor resikonya dapat berupa kebiasaan merokok, defisiensi alfa-1 antitripsin, sedangkan pada anak dapat disebabkan kondisi idiopatik, dan late sequelae penyakit paru kronik yang terkait dengan kelahiran prematur. Giant bullae dapat terjadi akibat komplikasi dari emfisema. Pasien dengan bullae mungkin asimtomatik, namun dengan semakin membesarnya ukuran bullae, dapat menimbulkan keluhan dispneu, nyeri dada, maupun hemoptisis. Pemeriksaan radiologi untuk menegakkan diagnosis yaitu; foto thorax, ct scan thorax, ultrasonografi thorax, kedokteran nuklir dan angiografi
Using the Context of Pempek on the Algebraic Form Operation for Jumping Task
Authors: Fitri Azela , Putri Ratu Ilma Indra 
Published: February 2021

Jumping task is a part of learning process on LSLC. Moreover, Jumping Task as the central part of teaching that uses Higher Order Thinking Skills (HOTS) and in Indonesia, The 2013 Curriculum emphasizes learning using HOTS, and the daily life context. This research aimed to find out the characteristic of jumping tasks which valid, practical, and also useful for supporting secondary school students learning algebraic form operation using PMRI with the context of pempek. The subject of this research was seventh-grade students of secondary school in Palembang. This research uses PMRI as the content materials and contexts. Results of this research are valid ant practical jumping tasks on mathematucs topic algebraic form operation. Moreover, using context of pempek for jumping task, students can learning algebraic form operation.
PENGARUH DOSIS PUPUK KANDANG SAPI DAN MIKORIZA TERHADAP PERTUMBUHAN TANAMAN JAGUNG (Zea mays L.)
Authors: Wiyono  , Harieni Setie , Daryanti  , Budiyono Agus , Umam Qoirul 
Published: February 2021

In Indonesia, maize is the second important food crop after rice. Corn is a potential raw material for the food industry, processed products for home industries, as well as feed so that the need continues to increase. Meanwhile, maize production is currently not sufficient to meet the needs, so the shortage is still met from imports. This study aims to determine the effect of cow manure and mycorrhizal doses on the growth of maize (Zea mays.L). The research was conducted in Gejugan Village, Andong District, Boyolali Regency, with a height of 154 m above sea level on the Grumusol soil type. This study used a completely randomized block design (RAKL) with two treatment factors, namely cow manure dosage factors (0, 10, 20, and 30 tonnes/ha) and mycorrhizae (0, 5, 10 g / plant) with 3 replications. The results showed that the dose of cow manure affected the growth of maize plants, while the mycorrhizal dose only affected the growth of corn plant roots. The interaction effect of cow manure dose with mycorrhizae occurred on root growth of corn plants. The best maize growth was obtained in the combination of 30 ton/ha manure dose treatment with 10g / plant mycorrhizae which produced the highest dry weight of stover (97.39 g), and the lowest dry weight (61.00 g) was obtained in the treatment without cow manure and mycorrhizae.