bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Nanocoating Co‐Localizing Nitric Oxide and Growth Factor onto Individual Endothelial Cells Reveals Synergistic Effects on Angiogenesis
Authors: Jeong Hyejoong , Choi Daheui , Oh Yoogyeong , Heo Jiwoong , Hong Jinkee 
Published: November 2021

AbstractThe delivery of nitric oxide (NO)—an intrinsic cellular signaling molecule—is promising for disease treatment, in particular to vascular diseases, due to its endothelial‐derived inherent nature. The limited diffusion distance of labile NO prompts researchers to develop various carriers and targeting methods for specific sites. In contrast to the apoptotic effect of NO, such as anticancer, delivering low NO concentration at the desired targeting area is still intricate in a physiological environment. In this study, the layer‐by‐layer assembled nanocoating is leveraged to develop a direct NO delivery platform to individual endothelial cells (ECs). NO can be localized to individual ECs viaS‐nitrosothiol‐bound polyacrylic acid which is a polymer directly providing an endothelial‐like constant level of NO. To increase angiogenic activation along with NO, VEGF is additionally applied to specific receptors on the cell surface. Notably, the survival and proliferation of ECs are significantly increased by a synergistic effect of NO and VEGF co‐localized via nanocoating. Furthermore, the nanocoating remarkably promoted cell migration and tubule formation—prerequisites of angiogenesis. The proposed unique technology based on nanocoating demonstrates great potential for conferring desired angiogenic functions to individual ECs through efficient NO delivery.
Laser Direct Writing of Highly Ordered Two‐Level Hierarchical Microstructures for Flexible Piezoresistive Sensor with Enhanced Sensitivity
Authors: Zhang Chenying , Chen Rui , Xiao Chiqian , Zhao Huiyan , Wang Yuxin , Geng Da , Chen Songyue , Luo Tao , Zhou Wei 
Published: November 2021

AbstractWith the development of micro‐nano manufacturing technology, various hierarchical microstructures (HMs) are used to improve the sensitivity and measurement range of flexible pressure sensors. However, the fabrication of highly ordered HMs in simple, fast, and low‐cost ways remains a great challenge. In this work, laser direct writing technology is used to fabricate highly ordered HMs to enhance the sensitivity of flexible piezoresistive sensors. The HMs show a lateral expansion with the increasing pressure due to good flexibility and small force bearing areas, resulting in more significant change in contact area than the single‐level microstructures, which leads to an enhanced sensitivity. Two case studies are conducted to verify the performance of the sensor with laser processed HMs. Experimental results show that the pulsating blood pressure signal of radial artery can be detected by attaching the sensor on the wrist. When the sensor is attached on the neck, it can also detect the vibration signal of vocal cord when speaking. These results successfully demonstrate the potential of laser processing in fabricating highly ordered HMs to achieve highly sensitive flexible piezoresistive sensors for various applications, such as wearable health monitoring and human–computer interactions.
Multifunctional Dynamic Enamine‐Based Hydrogels with On‐Demand Removability for Wound Healing
Authors: Zeng Fanwei , Jiang Xueyu , Zhang Hao , Chen Minzhang , Lu Ang , Yu Aixi 
Published: November 2021

AbstractTo meet the urgent requirement in complex wound treatment, the injectable self‐healing biocompatible hydrogel with tunable mechanical properties, adhesion, on‐demanding removability, antibacterial properties, and hemostasis is designed. For the first time, hydrogels are fabricated through dynamic enamine bonds among dodecane grafted quaternized chitosan (DQCS) and ketone group functionalized polyvinyl alcohol (PVA‐Ket) to achieve efficient wound closure. Owing to the dynamic enamine bond, the hydrogel exhibits self‐healing, injectability and suitable mechanical properties. It can be easily injected into wound, adhere tightly, and bear deformation damage. Dodecyl groups and quaternary amine groups endow the biocompatible hydrogels outstanding antibacterial feature, hemostatic performance, and tissue adhesiveness (40.05 ± 3.21 kPa), which greatly facilitate the wound healing process. Owing to interaction between the amino acid and PVA‐Ket, the hydrogel exhibits painless on‐demand dissolution behavior, causing uninjurious separation from wound sites. Furthermore, in vivo study demonstrates that the hydrogel promotes wound healing by upregulating growth factors, alleviating the inflammation and promoting angiogenesis, collagen deposition, and the growth of granulation tissue, leading to a better curative effect than the commercial gauze and Atrauman. Ag in infected and uninfected wounds. Thus, the multifunctional dynamic enamine‐based hydrogel with on‐demand removability has great potential in clinical applications.
Magnetically Steerable Serial and Parallel Structures by Mold‐Free Origami Templating and Domain Setting
Authors: Yeow Bok Seng , Yang Haitao , Sivaperuman Kalairaj Manivannan , Gao Huxin , Cai Catherine Jiayi , Xu Shilei , Chen Po‐Yen , Ren Hongliang 
Published: November 2021

AbstractMagnetically responsive elastomers generate continuous motions and locomotion through changes in external magnetic fields. The magnetic particles in an elastomer achieve shape‐morphing, but overall structural integrity can be limited by the compliance of elastomers. To overcome this limitation, magnetic elastomers are enhanced with programmable template creases to generate deployable structures as a library. Current methods to program magnetic domains into actuatable segments use sequential or continuous rasterized magnetization, which is gradual and requires dedicated equipment. To achieve faster magnetic domain programming, template folding for the magnetization process is explored. The crease pattern can reconfigure facets to attain the desired magnetization direction and act as discrete mechanical joints. Crease patterns from the foldable templates allow more variations in robotic kinematics and discretize the deformations. The approach using magnetic elastomers and folding templates as a library can simultaneously program a wide range of deployable mechanisms with inherent crease foldability. Additionally, magnetic responsive robots can encompass bistable actuation imparted from the crease design. Functionalization of magnetic origami structures is demonstrated by imbuing the template material with catalytic properties. These robots have the potential to be deployed from a compact folded form to confined environments, enabling a broader spectrum of minimally invasive procedures.
A Diastereoselective Catalytic Approach to Pentasubstituted Pyrrolidines by Tandem Anionic‐Radical Cross‐Over Reactions
Authors: Hidasová Denisa , Pohl Radek , Císařová Ivana , Jahn Ullrich 
Published: November 2021

AbstractPentasubstituted pyrrolidines are ubiquitous constituents of natural products and drugs, however the access options to them especially with respect to absolute and relative stereochemistry are not well developed. We report an asymmetric synthesis of N,2,3,4,5‐pentasubstituted pyrrolidines by oxidative single‐electron transfer‐catalyzed tandem aza‐Michael addition/radical 5‐exo cyclization/oxygenation reactions. The absolute stereochemistry is set by applying readily accessible chiral allylamines in asymmetric conjugate additions to various β‐substituted‐α,β‐unsaturated esters, which dependent on the substituent R2 sets the configuration of the two stereocenters next to the amine function, whereas two more are diastereoselectively generated by the radical 5‐exo cyclization step. This allows the diastereodivergent single‐step synthesis of pyrrolidines with four contiguous stereogenic centers. The stereoselectivity is rationalized by a predictive model.magnified image
Manganese(III)‐Promoted Double Carbonylation of Anilines Toward α‐Ketoamides Synthesis
Authors: Chen Bo , Kuai Chang‐Sheng , Xu Jian‐Xing , Wu Xiao‐Feng 
Published: November 2021

AbstractEmploying anilines as nucleophiles in double carbonylation is a longstanding challenge. In this communication, a Mn(III)‐promoted double carbonylation of alkylborates or Hantzsch esters with anilines toward the synthesis of α‐ketoamides has been developed. By using easily available potassium alkyltrifluoroborates or Hantzsch esters as the starting material, and cheap and non‐toxic Mn(OAc)3 ⋅ 2H2O as the promotor, a broad range of alkyl α‐ketoamide derivatives were synthesized in moderate to good yields with excellent selectivity.magnified image
Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M‐Type Voltage‐Gated Potassium Channels
Authors: Abdullaeva Oliya S. , Sahalianov Ihor , Silverå Ejneby Malin , Jakešová Marie , Zozoulenko Igor , Liin Sara I. , Głowacki Eric Daniel 
Published: November 2021

AbstractH2O2 plays a significant role in a range of physiological processes where it performs vital tasks in redox signaling. The sensitivity of many biological pathways to H2O2 opens up a unique direction in the development of bioelectronics devices to control levels of reactive‐oxygen species (ROS). Here a microfabricated ROS modulation device that relies on controlled faradaic reactions is presented. A concentric pixel arrangement of a peroxide‐evolving cathode surrounded by an anode ring which decomposes the peroxide, resulting in localized peroxide delivery is reported. The conducting polymer (poly(3,4‐ethylenedioxythiophene) (PEDOT), is exploited as the cathode. PEDOT selectively catalyzes the oxygen reduction reaction resulting in the production of hydrogen peroxide (H2O2). Using electrochemical and optical assays, combined with modeling, the performance of the devices is benchmarked. The concentric pixels generate tunable gradients of peroxide and oxygen concentrations. The faradaic devices are prototyped by modulating human H2O2‐sensitive Kv7.2/7.3 (M‐type) channels expressed in a single‐cell model (Xenopus laevis oocytes). The Kv7 ion channel family is responsible for regulating neuronal excitability in the heart, brain, and smooth muscles, making it an ideal platform for faradaic ROS stimulation. The results demonstrate the potential of PEDOT to act as an H2O2 delivery system, paving the way to ROS‐based organic bioelectronics.
Synergistic Engineering of Side Chains and Backbone Regioregularity of Polymer Acceptors for High‐Performance All‐Polymer Solar Cells with 15.1% Efficiency
Authors: Sun Cheng , Lee Jin‐Woo , Seo Soodeok , Lee Seungjin , Wang Cheng , Li Huan , Tan Zhengping , Kwon Soon‐Ki , Kim Bumjoon J. , Kim Yun‐Hi 
Published: November 2021

AbstractTuning the aggregation and crystalline properties of polymers is critical for realizing all‐polymer solar cells (all‐PSCs) with optimal blend morphology and high power conversion efficiency (PCE). In this study, a series of polymerized small‐molecule acceptors (PSMAs) is developed to investigate important relationships among their crystalline/aggregation properties, the blend morphology, and the device performance of the resulting all‐PSCs. A series of PSMAs (regiorandom (RRd)‐C12, RRd‐C20, RRd‐C24, regioregular (RRg)‐C20, and RRg‐C24) with simultaneously‐engineered i) side chain lengths of C12, C20, and C24, and ii) backbone regioregularities of RRd and RRg are synthesized to regulate their crystalline/aggregation properties. As a result, the highest PCE of 15.12% is obtained with all‐PSCs based on RRg‐C20 PSMA having regioregular backbone and optimal side chain length, attributed to high PSMA crystallinity and electron mobility as well as optimal blend morphology with a polymer donor. Thus, this study demonstrates the importance of simultaneous engineering of the backbone regioregularity and side‐chain structures of PSMAs to enhance electron mobility, optimize blend morphology and, thus, achieve highly efficient all‐PSCs.
Autoimmune conditions in the World Trade Center general responder cohort: A nested case‐control and standardized incidence ratio analysis
Authors: Sacks Henry S. , Smirnoff Margaret , Carson Deborah , Cooney Michael L. , Shapiro Moshe Z. , Hahn Christopher J. , Dasaro Christopher R. , Crowson Cynthia , Tassiulas Ioannis , Hirten Robert P. , Cohen Benjamin L. , Haber Richard S. , Davies Terry F. , Simpson David M. , Crane Michael A. , Harrison Denise J. , Luft Benjamin J. , Moline Jacqueline M. , Udasin Iris G. , Todd Andrew C. , Sloan Nancy L. , Teitelbaum Susan L. 
Published: November 2021

AbstractBackgroundThe World Trade Center (WTC) general responder cohort (GRC) was exposed to environmental toxins possibly associated with increased risk of developing autoimmune conditions.ObjectivesTwo study designs were used to assess incidence and risks of autoimmune conditions in the GRC.MethodsThree clinically trained professionals established the status of possible GRC cases of autoimmune disorders adhering to diagnostic criteria, supplemented, as needed, by specialists’ review of consenting responders’ medical records. Nested case‐control analyses using conditional logistic regression estimated the risk associated with high WTC exposure (being in the 9/11/2001 dust cloud or ≥median days' response worked) compared with low WTC exposure (all other GRC members'). Four controls were matched to each case on age at case diagnosis (±2 years), sex, race/ethnicity, and year of program enrollment. Sex‐specific and sensitivity analyses were performed. GRC age‐ and sex‐adjusted standardized incidence ratios (SIRs) were compared with the Rochester Epidemiology Project (REP). Complete REP inpatient and outpatient medical records were reviewed by specialists. Conditions meeting standardized criteria on ≥2 visits were classified as REP confirmed cases.ResultsSix hundred and twenty‐eight responders were diagnosed with autoimmune conditions between 2002 and 2017. In the nested case‐control analyses, high WTC exposure was not associated with autoimmune domains and conditions (rheumatologic domain odds ratio [OR] = 1.03, 95% confidence interval [CI] = 0.77, 1.37; rheumatoid arthritis OR = 1.12, 95% CI = 0.70, 1.77). GRC members had lower SIR than REP. Women's risks were generally greater than men's.ConclusionsThe study found no statistically significant increased risk of autoimmune conditions with WTC exposures.
A Nanohook‐Equipped Bionanocatalyst for Localized Near‐Infrared‐Enhanced Catalytic Bacterial Disinfection
Authors: Fan Xin , Wu Xizheng , Yang Fan , Wang Lei , Ludwig Kai , Ma Lang , Trampuz Andrej , Cheng Chong , Haag Rainer 
Published: November 2021

AbstractNovel bionanocatalysts have opened a new era in fighting multidrug‐resistant (MDR) bacteria. They can kill bacteria by elevating the level of reactive oxygen species (ROS) in the presence of chemicals like H2O2. However, ROSs’ ultrashort diffusion distance limit their bactericidal activity. We present a nanohook‐equipped bionanocatalyst (Ni@Co‐NC) with bacterial binding ability that shows robust ROS‐generating capacity under physiological H2O2 levels. The Ni@Co‐NC's pH‐dependent performance confines its effects to the biofilm microenvironment, leaving healthy tissue unaffected. Furthermore, it can generate heat upon NIR laser irradiation, enhancing its catalytic performance while achieving heat ablation against bacteria. With the Ni@Co‐NC's synergistic effects, bacterial populations fall by >99.99 %. More surprisingly, the mature biofilm shows no recurrence after treatment with the Ni@Co‐NC, demonstrating its tremendous potential for treating MDR bacterial related infections.
Vektorielle Katalyse mit oberflächenverankerten nano‐metallorganischen Gerüsten in mikrofluidischen Reaktoren
Authors: Semrau Anna Lisa , Stanley Philip M. , Huber Dominik , Schuster Michael , Albada Bauke , Zuilhof Han , Cokoja Mirza , Fischer Roland A. 
Published: November 2021

AbstractVektorielle Katalyse – die Steuerung von mehrstufigen Reaktionen in einer programmierten Abfolge und durch definierte räumliche Lokalisierung in einem mikroskaligen Reaktor – ist ein grundlegendes Ziel in der bioinspirierten Katalyseforschung. Die Übertragung von Konzepten aus der natürlichen Kaskaden‐Biokatalyse zu künstlichen hierarchischen chemischen Systeme bleibt jedoch eine Herausforderung. Hier zeigen wir die Integration von zwei verschiedenen oberflächenverankerten, nanometergroßen metallorganischen Gerüsten (MOFs) in einem mikrofluidischen Reaktor zur Modellierung der vektoriellen Katalyse. Die Katalysatoren wurden an definierten Abschnitten entlang des Mikrokanals immobilisiert, dies ermöglichte eine zweistufige Kaskadenreaktion mit vollständiger Umsetzung nach 30 Sekunden und hohen Umsatzfrequenzen (TOF≈105 h−1).
Peptide–Bismuth Bicycles: In Situ Access to Stable Constrained Peptides with Superior Bioactivity
Authors: Voss Saan , Rademann Jörg , Nitsche Christoph 
Published: November 2021

AbstractConstrained peptides are promising next‐generation therapeutics. We report here a fundamentally new strategy for the facile generation of bicyclic peptides using linear precursor peptides with three cysteine residues and a non‐toxic trivalent bismuth(III) salt. Peptide–bismuth bicycles form instantaneously at physiological pH, are stable in aqueous solution for many weeks, and much more resistant to proteolysis than their linear precursors. The strategy allows the in situ generation of bicyclic ligands for biochemical screening assays. We demonstrate this for two screening campaigns targeting the proteases from Zika and West Nile viruses, revealing a new lead compound that displayed inhibition constants of 23 and 150 nM, respectively. Bicyclic peptides are up to 130 times more active and 19 times more proteolytically stable than their linear analogs without bismuth.
Local Environment Determined Reactant Adsorption Configuration for Enhanced Electrocatalytic Acetone Hydrogenation to Propane
Authors: Wang Xuesi , Jiao Yan , Li Laiquan , Zheng Yao , Qiao Shi‐Zhang 
Published: November 2021

AbstractWe demonstrate a widely applicable method to alter the adsorption configuration of multi‐carbon containing reactants by no catalyst engineering but simply adjusting the local reaction environment of the catalyst surface. Using electrocatalytic acetone to propane hydrogenation (APH) as a model reaction and common commercial Pt/Pt‐based materials as catalysts, we found local H+ concentration can significantly influence the adsorption mode of acetone reactant, for example, in vertical or flat mode, and target product selectivity. Electrocatalytic measurement combined with in situ spectroscopic characterizations reveals that the vertically adsorbed acetone is favorable for propane production while the flatly adsorbed mode suppresses the reaction. DFT calculations indicate that the H coverage on catalyst surface plays a decisive role in the adsorption configuration of acetone. The increased local acidity can facilitate the adsorption configuration of acetone from flat to vertical mode and suppress the competing hydrogen evaluation reaction, which consequently enhances the APH selectivity.
Polylactic acid/recycled wind turbine glass fiber composites with enhanced mechanical properties and toughness
Authors: Moslehi Amirhosein , Ajji Abdellah , Heuzey Marie‐Claude , Rahimizadeh Amirmohammad , Lessard Larry 
Published: November 2021

AbstractThe amount of composite waste from decommissioned wind turbine blades grows rapidly and recycling solutions should be generated to overcome this environmental challenge. This research aims to further develop a recycling method to recover components of dismantled turbine blades by reusing them as reinforcement for new composites. Recycled short glass fibers from shredded blade composites are incorporated into polylactic acid (PLA) to fabricate a composite (15 wt% fiber) that could be used for 3D filament fabrication. To improve the mechanical properties of the composite, a coupling agent was employed to refine the interactions between PLA and recycled glass fibers at the interface of the two components and enhance the adhesion. Due to the inherent brittleness of PLA, which is aggravated with the addition of recycled glass fibers, a toughening agent involving chain‐end modification was incorporated into the composite to improve the toughness of the system. The concurrent outcome of the coupling agent and the toughener on the morphology, mechanical properties and thermal behavior of the composite was evaluated. The incorporation of 1,2,3,4‐butane tetracarboxylic acid and silane‐treating of the recycled fibers improved the strength by 30% and elongation at break and impact strength of the composite 3 and 2 times, respectively.
Domain‐topic models with chained dimensions: Charting an emergent domain of a major oncology conference
Authors: Hannud Abdo Alexandre , Cointet Jean‐Philippe , Bourret Pascale , Cambrosio Alberto 
Published: November 2021

AbstractThis paper presents a contribution to the study of bibliographic corpora through science mapping. From a graph representation of documents and their textual dimension, stochastic block models can provide a simultaneous clustering of documents and words that we call a domain‐topic model. Previous work investigated the resulting topics, or word clusters, while ours focuses on the study of the document clusters we call domains. To enable the description and interactive navigation of domains, we introduce measures and interfaces that consider the structure of the model to relate both types of clusters. We then present a procedure that extends the block model to cluster metadata attributes of documents, which we call a domain‐chained model, noting that our measures and interfaces transpose to metadata clusters. We provide an example application to a corpus relevant to current science, technology and society (STS) research and an interesting case for our approach: the abstracts presented between 1995 and 2017 at the American Society of Clinical Oncology Annual Meeting, the major oncology research conference. Through a sequence of domain‐topic and domain‐chained models, we identify and describe a group of domains that have notably grown through the last decades and which we relate to the establishment of “oncopolicy” as a major concern in oncology.
Destination exoplanet: Habitability conditions influenced by stellar winds properties
Authors: Chebly Judy J. , Alvarado‐Gómez Julián D. , Poppenhaeger Katja 
Published: November 2021

AbstractThe cumulative effect of the magnetized stellar winds on exoplanets dominates over other forms of star‐planet interactions. When combined with photoevaporation, these winds will lead to atmospheric erosion. This is directly connected with the concept of habitable zone (HZ) planets around late‐type stars. Our knowledge of these magnetized winds is limited, making numerical models useful tools to explore them. In this preliminary study, we focus on solar‐like stars exploring how different stellar wind properties scale with one another. We used one of the most detailed physics‐based models, the 3D Alfvén wave solar model part of the Space Weather Modeling Framework, and applied it to the stellar winds domain. Our simulations showed that the magnetic field topology on the star surface plays a fundamental role in shaping the different stellar wind properties (wind speed, mass loss rate, and angular momentum loss rate). We conclude that a characterization of the Alfvén surface is crucial when studying star‐planet interaction as it can serve as an inner‐boundary of the HZ.