bluuebunny/crossref_metadata_2025_split huggingface dataset:
We Have a Lot to Do: Lack of Sexual Protection and Information—Results of the German-Language Online Survey “Let's Talk About Chemsex”
Authors: Rosenberger Cornelia , Gertzen Marcus , Strasburger Moritz , Schwarz Johanna , Gernun Solveig , Rabenstein Andrea , Lermer Eva , Rüther Tobias 
Published: May 2021

Background: The prevalence of chemsex and sexualized substance use is increasing in several European countries, particularly among men who have sex with men. In this subgroup, illegal substance use is associated with increased sexual risk behavior, which can result in severe physical and psychological impairments. The present study examined the incidence and prevalence of chemsex in German-speaking countries.Methods: To further describe the high-risk group of Chemsex users, participants (N = 429) were asked about their psychotropic substance use, sexual and health-related behavior, health status, and socio-demographic information by using an online questionnaire. Whether Chemsex has negative effects on well-being was measured with the WHO well-being index. Of additional interest was how informed Chemsex users are about the topic and what needs are placed on the practitioners. The online questionnaire consisted of 105 items, and data was collected from March to May 2019. Thousand forty seven datasets were saved with a dropout rate of 59%, 123 completed questionnaires fulfilled the criteria for chemsex users (n =123).Results: There were no significant differences in well-being between chemsex users and non-users. All participants protected themselves against sexually transmitted diseases irregularly or not at all. The majority of chemsex users reported intermittently using illegal substances (ketamine, methamphetamine, mephedrone, γ-butyrolactone/γ-hydroxy butyric acid). They viewed their sexual and substance use behavior as problematic, but few showed motivation for behavior change. Chemsex users clearly expressed a need for more information and advice centers.Conclusion: The results provide information on chemsex users that can be used for the future development of a therapy manual and thus contribute to improving health care for this group. The prevalence of chemsex is increasing and urgently needs more research to protect clients from health impairments and stigmatization.
Shift to Virtual Self-Management Programs During COVID-19: Ensuring Access and Efficacy for Older Adults
Authors: Sanchez-Villagomez Pamela , Zurlini Claudia , Wimmer Maggie , Roberts Linda , Trieu Bertilia , McGrath Bonnie , Wiesel Robyn , Ologhobo Titilayo , Goldsmith Sandra , Robbins Laura 
Published: May 2021

Background: The COVID-19 pandemic resulted in significant uncertainty and disruption to many aspects of daily living, including physical activity, socialization opportunities, and access to healthcare services. Under these conditions, at-risk older adults are even more likely to be inactive and isolated, leading to potential exacerbation of musculoskeletal and chronic conditions and emotional distress. This case study provides an overview of our experience and best practices developed during our shift from onsite programming to virtual.Methodology: HSS utilized varied online approaches, including phone/video conference classes, webinars, on-demand videos and email campaigns to successfully transition programs. Due to this shift, HSS changed its evaluation to an online approach, using a mixed method to adequately assess the impact of programs.Results: Between April and August 2020, our virtual programs reached 428,766 participants, resulting in a 10,807% increase in program reach. Most participants assessed were 60 years or older (72%) and reported knowledge (85%) and self-management skills (83%) gained as well as high program satisfaction (90%). Analyses of program data did not show any statistical significant difference in self-reported health outcomes. However, qualitative results showed virtual programming helped to foster social connectivity during COVID-19, helped to build a daily routine, and positively impacted mental and physical health.Conclusion: Shifting to virtual programming in the face of the pandemic enabled us to deliver effective programs affording our community the opportunity to stay physically active and socially connected despite the quarantine orders.
A Clinical Analysis of the Treatment of Chronic Coronary Artery Occlusion With Antegrade Dissection Reentry
Authors: Wu Xiangjun , Zhang Dan , Liu Haitao , Li Shuai , Fu Chao , Liu Jiyuan , Cui Jiayu 
Published: May 2021

Objective: This study aimed to investigate the efficacy and safety of antegrade dissection re-entry (ADR) technique in the percutaneous coronary intervention (PCI) to open chronic total occlusion (CTO) lesions.Methods: The baseline, angiographic results, PCI success rate, and major adverse cardiac events (MACE) during the 12 months of follow-up were compared between 48 patients who did not use ADR in the treatment of CTO lesions (control group) and 50 patients who used ADR (treatment group).Results: The control group comprised 48 patients who had 52 CTO lesions, and the treatment group comprised 50 patients who had 58 CTO lesions. The success rate of PCI in the treatment group (89.7 vs. 71.2%, P = 0.047) was significantly higher than in the control group, where six patients had in-stent restenosis (ISR, ISR-CTO) that were all recanalized. The mean PCI time (71 ± 25 min vs. 95 ± 33 min, P = 0.041), X-ray exposure time (42 ± 17 min vs. 71 ± 22 min, P = 0.032), contrast agent dosage (98 ± 26 ml vs. 178 ± 63 ml, P = 0.029), MACE incidence during the 12 months of follow-up (22.0 vs. 41.7%, P = 0.046) and recurrent myocardial infarction incidence (10.0 vs. 27.1%, P = 0.047) were significantly lower in the treatment group than in the control group. The differences were all statistically significant.Conclusion: It is safe and effective to use the ADR technique in PCI for coronary artery CTO lesions. The technique shortens the operation time, reduces the radiation dose of doctors and patients and the use dose of contrast agents, and improves patients' prognoses.
A Synchrotron and Micro-CT Study of the Human Endolymphatic Duct System: Is Meniere's Disease Caused by an Acute Endolymph Backflow?
Authors: Li Hao , Rajan Gunesh P. , Shaw Jeremy , Rohani Seyed Alireza , Ladak Hanif M. , Agrawal Sumit , Rask-Andersen Helge 
Published: May 2021

Background: The etiology of Meniere's disease (MD) and endolymphatic hydrops believed to underlie its symptoms remain unknown. One reason may be the exceptional complexity of the human inner ear, its vulnerability, and surrounding hard bone. The vestibular organ contains an endolymphatic duct system (EDS) bridging the different fluid reservoirs. It may be essential for monitoring hydraulic equilibrium, and a dysregulation may result in distension of the fluid spaces or endolymphatic hydrops.Material and Methods: We studied the EDS using high-resolution synchrotron phase contrast non-invasive imaging (SR-PCI), and micro-computed tomography (micro-CT). Ten fresh human temporal bones underwent SR-PCI. One bone underwent micro-CT after fixation and staining with Lugol's iodine solution (I2KI) to increase tissue resolution. Data were processed using volume-rendering software to create 3D reconstructions allowing orthogonal sectioning, cropping, and tissue segmentation.Results: Combined imaging techniques with segmentation and tissue modeling demonstrated the 3D anatomy of the human saccule, utricle, endolymphatic duct, and sac together with connecting pathways. The utricular duct (UD) and utriculo-endolymphatic valve (UEV or Bast's valve) were demonstrated three-dimensionally for the first time. The reunion duct was displayed with micro-CT. It may serve as a safety valve to maintain cochlear endolymph homeostasis under certain conditions.Discussion: The thin reunion duct seems to play a minor role in the exchange of endolymph between the cochlea and vestibule under normal conditions. The saccule wall appears highly flexible, which may explain occult hydrops occasionally preceding symptoms in MD on magnetic resonance imaging (MRI). The design of the UEV and connecting ducts suggests that there is a reciprocal exchange of fluid among the utricle, semicircular canals, and the EDS. Based on the anatomic framework and previous experimental data, we speculate that precipitous vestibular symptoms in MD arise from a sudden increase in endolymph pressure caused by an uncontrolled endolymphatic sac secretion. A rapid rise in UD pressure, mediated along the fairly wide UEV, may underlie the acute vertigo attack, refuting the rupture/K+-intoxication theory.
Identification and Validation of a Prognostic 5-Protein Signature for Biochemical Recurrence Following Radical Prostatectomy for Prostate Cancer
Authors: Lv Daojun , Cao Zanfeng , Li Wenjie , Zheng Haige , Wu Xiangkun , Liu Yongda , Gu Di , Zeng Guohua 
Published: May 2021

Background: Biochemical recurrence (BCR) is an indicator of prostate cancer (PCa)-specific recurrence and mortality. However, there is a lack of an effective prediction model that can be used to predict prognosis and to determine the optimal method of treatment for patients with BCR. Hence, the aim of this study was to construct a protein-based nomogram that could predict BCR in PCa.Methods: Protein expression data of PCa patients was obtained from The Cancer Proteome Atlas (TCPA) database. Clinical data on the patients was downloaded from The Cancer Genome Atlas (TCGA) database. Lasso and Cox regression analyses were conducted to select the most significant prognostic proteins and formulate a protein signature that could predict BCR. Subsequently, Kaplan–Meier survival analysis and Cox regression analyses were conducted to evaluate the performance of the prognostic protein-based signature. Additionally, a nomogram was constructed using multivariate Cox regression analysis.Results: We constructed a 5-protein-based prognostic prediction signature that could be used to identify high-risk and low-risk groups of PCa patients. The survival analysis demonstrated that patients with a higher BCR showed significantly worse survival than those with a lower BCR (p &lt; 0.0001). The time-dependent receiver operating characteristic curve showed that the signature had an excellent prognostic efficiency for 1, 3, and 5-year BCR (area under curve in training set: 0.691, 0.797, 0.808 and 0.74, 0.739, 0.82 in the test set). Univariate and multivariate analyses indicated that this 5-protein signature could be used as independent prognosis marker for PCa patients. Moreover, the concordance index (C-index) confirmed the predictive value of this 5-protein signature in 3, 5, and 10-year BCR overall survival (C-index: 0.764, 95% confidence interval: 0.701–0.827). Finally, we constructed a nomogram to predict BCR of PCa.Conclusions: Our study identified a 5-protein-based signature and constructed a nomogram that could reliably predict BCR. The findings might be of paramount importance for the prediction of PCa prognosis and medical decision-making.Subjects: Bioinformatics, oncology, urology.
Endolymphatic Hydrops in Fluctuating Hearing Loss and Recurrent Vertigo
Authors: Domínguez Pablo , Manrique-Huarte Raquel , Suárez-Vega Víctor , López-Laguna Nieves , Guajardo Carlos , Pérez-Fernández Nicolás 
Published: May 2021

Background: Endolymphatic hydrops (EH) is the histopathological hallmark of Ménière's disease (MD) and has been found by in vivo magnetic resonance imaging (MRI) in patients with several inner ear syndromes without definite MD criteria. The incidence and relevance of this finding is under debate.Purpose: The purpose of the study is to evaluate the prevalence and characteristics of EH and audiovestibular test results in groups of patients with fluctuating audiovestibular symptoms not fulfilling the actual criteria for definite MD and compare them with a similar group of patients with definite MD and a group of patients with recent idiopathic sudden neurosensory hearing loss (ISSNHL).Material and Methods: 170 patients were included, 83 with definite MD, 38 with fluctuating sensorineural hearing loss, 34 with recurrent vertigo, and 15 with ISSNHL. The clinical variables, audiovestibular tests, and EH were evaluated and compared. Logistic proportional hazard models were used to obtain the odds ratio for hydrops development, including a multivariable adjusted model for potential confounders.Results: No statistical differences between groups were found regarding disease duration, episodes, Tumarkin spells, migraine, vascular risk factors, or vestibular tests; only hearing loss showed differences. Regarding EH, we found significant differences between groups, with odds ratio (OR) for EH presence in definite MD group vs. all other patients of 11.43 (4.5–29.02; p &lt; 0.001). If the ISSNHL group was used as reference, OR was 55.2 (11.9–253.9; p &lt; 0.001) for the definite MD group, 9.9 (2.1–38.9; p = 0.003) for the recurrent vertigo group, and 5.1 (1.2–21.7; p = 0.03) for the group with fluctuating sensorineural hearing loss.Conclusion: The percentage of patients with EH varies between groups. It is minimal in the ISSNHL group and increases in groups with increasing fluctuating audiovestibular symptoms, with a rate of severe EH similar to the known rate of progression to definite MD in those groups, suggesting that presence of EH by MRI could be related to the risk of progression to definite MD. Thus, EH imaging in these patients is recommended.
Influence of the Passive Stabilization of the Trunk and Upper Limb on Selected Parameters of the Hand Motor Coordination, Grip Strength and Muscle Tension, in Post-Stroke Patients
Authors: Olczak Anna , Truszczyńska-Baszak Aleksandra 
Published: May 2021

Objective: Assessment of the influence of a stable trunk and the affected upper limb (dominant or non-dominant) on the parameters of the wrist and hand motor coordination, grip strength and muscle tension in patients in the subacute post-stroke stage compared to healthy subjects. Design: An observational study. Setting: Stroke Rehabilitation Department. Subjects: Thirty-four subjects after ischemic cerebral stroke and control group-32 subjects without neurological deficits, age and body mass/ height matched were included. Main measures: The tone of the multifidus, transverse abdominal and supraspinatus muscles were assessed by Luna EMG device. A HandTutor device were used to measure motor coordination parameters (e.g., range of movement, frequency of movement), and a manual dynamometer for measuring the strength of a hand grip. Subjects were examined in two positions: sitting without back support (non-stabilized) and lying with stabilization of the trunk and the upper limb. Results: Passive stabilization of the trunk and the upper extremity caused a significant improvement in motor coordination of the fingers (p ˂ 0.001) and the wrist (p < 0.001) in patients after stroke. Improved motor coordination of the upper extremity was associated with an increased tone of the supraspinatus muscle. Conclusions: Passive stabilization of the trunk and the upper limb improved the hand and wrist coordination in patients following a stroke. Placing patients in a supine position with the stability of the affected upper limb during rehabilitation exercises may help them to access latent movement patterns lost due to neurological impairment after a stroke.
The Effects of Chemical and Mechanical Stresses on Bacillus cereus and Pseudomonas fluorescens Single- and Dual-Species Biofilm Removal
Authors: Gomes Inês B. , Lemos Madalena , Fernandes Susana , Borges Anabela , Simões Lúcia C. , Simões Manuel 
Published: May 2021

Biofilm control is mainly based on chemical disinfection, without a clear understanding of the role of the biocides and process conditions on biofilm removal. This study aims to understand the effects of a biocide (benzyldimethyldodecyl ammonium chloride—BDMDAC) and mechanical treatment (an increase of shear stress -τw) on single- and dual-species biofilms formed by Bacillus cereus and Pseudomonas fluorescens on high-density polyethene (HDPE). BDMDAC effects were initially assessed on bacterial physicochemical properties and initial adhesion ability. Then, mature biofilms were formed on a rotating cylinder reactor (RCR) for 7 days to assess the effects of chemical and mechanical treatments, and the combination of both on biofilm removal. The results demonstrated that the initial adhesion does not predict the formation of mature biofilms. It was observed that the dual-species biofilms were the most susceptible to BDMDAC exposure. The exposure to increasing τw emphasised the mechanical stability of biofilms, as lower values of τw (1.66 Pa) caused high biofilm erosion and higher τw values (17.7 Pa) seem to compress the remaining biofilm. In general, the combination of BDMDAC and the mechanical treatment was synergic in increasing biofilm removal. However, these were insufficient to cause total biofilm removal (100%; an average standard deviation of 11% for the method accuracy should be considered) from HDPE.
Ontogenetic Changes in the Chemical Profiles of Piper Species
Authors: Gaia Anderson Melo , Yamaguchi Lydia Fumiko , Guerrero-Perilla Camilo , Kato Massuo Jorge 
Published: May 2021

The chemical composition of seedlings and adult plants of several Piper species were analyzed by 1H NMR spectroscopy combined with principal component analysis (PCA) and HPLC-DAD, HPLC-HRESIMS and GC-MS data. The chromatographic profile of crude extracts from leaves of Piper species showed remarkable differences between seedlings and adult plants. Adult leaves of P. regnellii accumulate dihydrobenzofuran neolignans, P. solmsianum contain tetrahydrofuran lignans, and prenylated benzoic acids are found in adult leaves of P. hemmendorffii and P. caldense. Seedlings produced an entirely different collection of compounds. Piper gaudichaudianum and P. solmsianum seedlings contain the phenylpropanoid dillapiole. Piper regnellii and P. hemmendorffii produce another phenylpropanoid, apiol, while isoasarone is found in P. caldense. Piper richadiaefolium and P. permucronatum contain dibenzylbutyrolactones lignans or flavonoids in adult leaves. Seedlings of P. richardiaefolium produce multiple amides, while P. permucronatum seedlings contain a new long chain ester. Piper tuberculatum, P. reticulatum and P. amalago produce amides, and their chemistry changes less during ontogeny. The chemical variation we documented opens questions about changes in herbivore pressure across ontogeny.
ANÁLISIS DE LA INVESTIGACIÓN “IMAGINARIOS SOCIALES DEL DESARROLLO HUMANO, SUBYACENTES EN LAS POLÍTICAS DE RESOCIALIZACIÓN DE MUJERES PROFESIONALES INTERNAS, EN EL CENTRO PENITENCIARIO VILLA CRISTINA DE LA CIUDAD DE ARMENIA, QUINDÍO, COLOMBIA”
Authors: Rambal-Simanca Martha Cecilia , Acuña-Sauriht Leylis Margarita 
Published: May 2021

El presente artículo es una carta al editor, en el se realiza un análisis a la investigación realizada por Quiceno, J; Morales, L & Cuellar, L (2015) denominada “Imaginarios sociales del desarrollo humano, subyacentes en las políticas de resocialización de mujeres profesionales internas, en el centro penitenciario Villa Cristina, de la ciudad de Armenia, Quindío, Colombia. Esta es una investigación cualitativa desde el método fenomenológico, utilizó técnicas para la recolección de la información como la entrevista y el grupo focal; participaron mujeres reclusas que son profesionales, por lo que el muestreo es no probabilístico de conveniencia. Se analizaron los datos en coherencia con el método fenomenológico, concluyendo que las políticas de resocialización aplicadas en ese centro carcelario femenino no logran cumplir con su objetivo, ni se emplean apropiadamente, por ello, los autores proponen el diseño de una política pública de resocialización diferencial.
Los criterios utilizados para evaluar esta investigación fueron: los propósitos del estudio, la revisión de la literatura, el diseño del estudio, el muestreo, la recopilación datos, el análisis de datos, el rigor general, las conclusiones y la trascendencia. A partir de lo anterior, se puede afirmar que la investigación de Quiceno y otros (2015) cumple con todos los criterios que evidencian el rigor teórico y metodológico empleado, por lo cual, goza de validez y confiabilidad.
Sakralitas Burung Enggang dalam Teologi Lokal Masyarakat Dayak Kanayatn
Authors: Sahertian Claudya Ingrid 
Published: May 2021

This article aims to explore the culture of the Dayak Kanayatn people regarding the rituals and sacredness of hornbills. Retrieval of data using qualitative research with the ethnography method, through interview techniques, observation, documentary studies, and literature studies. The community makes hornbills a sacred symbol. This attitude can be seen when the community carries out Karana traditional rituals as an implementation of local theology and narrates them in dances, carvings, carvings, and traditional clothing attributes. Through rituals, the community believes that the hornbill is a link between heaven (subayatn) and the world that brings people to death (pidara) into eternity. Hornbills have a significant influence on the Kanayatn Dayak indigenous people because they contain noble values. Everything related to hornbills, including their lifestyle, natural seed dispersers, forest guards, physical beauty, has become sacred to the Kanayatn Dayak community. This study concludes that the hornbill is a sacred symbol in local theology and capital of social integration for the Kanayatn Dayak community.AbstrakArtikel ini bertujuan untuk mengeksplorasi budaya masyarakat Dayak Kanayatn tentang ritual dan sakralitas burung Enggang. Pengambilan data menggunakan penelitian kualitatif dengan metode ethnografi dan nethnografi, melalui teknik wawancara, observasi, studi dokumenter dan studi pustaka. Masyarakat menjadikan burung Enggang sebagai simbol sakral. Sikap tersebut terlihat ketika masyarakat melaksanakan ritual adat Karana sebagai implementasi teologi lokal, serta menarasikannya dalam tarian, ukiran, pahatan dan atribut pakaian adat. Melalui ritual masyarakat meyakini bahwa burung Enggang sebagai penghubung surga (subayatn) dan dunia. Burung Enggang yang membawa orang meninggal (pidara) masuk kekekalan. Burung Enggang memberi pengaruh yang signifikan bagi masyarakat adat Dayak Kanayatn karena mengandung nilai-nilai yang luhur. Segala sesuatu yang berhubungan dengan burung Enggang baik pola hidup, pemencar biji alami, penjaga hutan, keindahan fisik, menjadi sakral bagi masyarkat Dayak Kanayatn. Penelitian ini menyimpulkan bahwa Burung Enggang adalah simbol sakral dalam teologi lokal dan modal integrasi sosial bagi masyarakat Dayak Kanayatn.
EVALUATION OF EDUCATION PROGRAM IMPLEMENTATION SCIENCE-BASED MADRASAH ALIYAH
Authors: Sopandi Evi , Siswanto Achmad 
Published: May 2021

Abstract:This research aims to evaluate the SAIN-based Madrasah Aliyah (MA) education program in Brebes, Central Java. The education program aims to improve the competence of human resources in improving ability. The evaluation model used in this study is the CIPP model (context, input, process, and product) of the qualitative research approach model introduced by Stufflebeam. The results showed that madrasah sains education program has been running well in accordance with the educational program that has been compiled. However, in the implementation of Madrasah SAIN education, there are still some shortcomings both in the field of funding (low teacher incentives), facilities and infrastructure (there are no adequate laboratories) and about the development of low human resources competencies of teachers.