bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histological study of the effect of bacterial lysates on the state of periodontal tissue in experimental periodontitis in rats
Authors: Ievtushenko Mariia , Koshova Olena , Kryzhna Svitlana 
Published: October 2021

The aim of the research: to experimentally study at the histological and morphological level the degree of the corrective effect of bacterial lysate of the disturbed non-specific defense of the body on the model of periodontitis based on the Central Research Laboratory of the National University of Pharmacy.
Materials and methods: prospective study has been conducted on experimental periodontitis in 42 rats for 90 days. The animals were treated with «Respibron» and the reference drug «Imudon». Histological and morphometric studies were carried out according to standard methods. Micropreparations were viewed under a Granum DCM 310 digital video camera. All interventions and euthanasia of animals were carried out in compliance with the European principles.
Results: by the end of 90 days of experimental periodontitis at the local level in the homogenate of animal gum tissue compensatory mechanisms are depleted and differed from the norm by 397 times. The dynamics of the studied morphometric and histological parameters of "Respibron" was similar to the "Imudon", but the magnitude of destruction was less pronounced and differed at the end of the experiment by 17.2 times in comparison with the intact control, and in the control group the results improved by 23.1 times.
Conclusion: the obtained data from the study indicate a high decompensation of experimental periodontitis. It is characterized by the formation of periodontal pockets and inflammatory bone loss. The magnitude of destruction differed from the norm by 397 times. Applying of bacterial lysates led to the compensation of bacterial dysbiosis, restoration of the tissues of paradont. The therapeutic effect of "Respibron" can be assessed as more powerful in comparison with "Imudon" in terms of the studied morphometric and histological parameters: the magnitude of improvement "Respibron" was 3.72 times higher than the indicators of "Imudon". We should continue the study of experimental periodontitis as mechanisms of development, protection, and restoration of tissues under conditions of pharmacological correction by bacterial lysate "Respibron"
MODELING OF ASYMPTOTICALLY OPTIMAL PIECEWISE LINEAR INTERPOLATION OF PLANE PARAMETRIC CURVES
Authors: Frolov О. V. , Losev M. U. 
Published: October 2021

Context. Piecewise linear approximation of curves has a large number of applications in computer algorithms, as the reconstruction of objects of complex shapes on monitors, CNC machines and 3D printers. In many cases, it is required to have the smallest number of segments for a given accuracy.
Objective. The objective of this paper is to improve the method of asymptotically optimal piecewise linear interpolation of plane parametric curves. This improvement is based to research influence of the method parameters and algorithms to distributions of approximation errors.
Method. An asymptotically optimal method of curves interpolation is satisfied to the condition of minimum number of approximation units. Algorithms for obtaining the values of the sequence of approximation nodes are suggested. This algorithm is based on numerical integration of the nodes regulator function with linear and spline interpolation of its values. The method of estimating the results of the curve approximation based on statistical processing of line segments sequence of relative errors is substantiated. Modeling of real curves approximation is carried out and influence of the sampling degree of integral function – the nodes regulator on distribution parameters of errors is studied. The influence is depending on a method of integral function interpolation.
Results. Research allows to define necessary the number of discretization nodes of the integral function in practical applications. There have been established that with enough sampling points the variance of the error’s distribution stabilizes and further increasing this number does not significantly increase the accuracy of the curve approximation. In the case of spline interpolation of the integral function, the values of the distribution parameters stabilized much faster, which allows to reduce the number of initial sampling nodes by 5–6 times having similar accuracy.
Conclusions. Modelling of convex planar parametric curves reconstruction by an asymptotically optimal linear interpolation algorithm showed acceptable results without exceeding the maximum errors limit in cases of a sufficient discretization of the integral function. The prospect of further research is to reduce the computational complexity when calculating the values of the integral distribution function by numerical methods, and to use discrete analogues of derivatives in the expression of this function.
THE METHOD OF STRUCTURAL ADJUSTMENT OF NEURAL NETWORK MODELS TO ENSURE INTERPRETATION
Authors: Leoshchenko S. D. , Oliinyk A. O. , Subbotin S. A. , Gofman Ye. O. , Korniienko O. V. 
Published: October 2021

Context. The problem of structural modification of pre-synthesized models based on artificial neural networks to ensure the property of interpretation when working with big data is considered. The object of the study is the process of structural modification of artificial neural networks using adaptive mechanisms.
Objective of the work is to develop a method for structural modification of neural networks to increase their speed and reduce resource consumption when processing big data.
Method. A method of structural adjustment of neural networks based on adaptive mechanisms borrowed from neuroevolutionary synthesis methods is proposed. At the beginning, the method uses a system of indicators to evaluate the existing structure of an artificial neural network. The assessment is based on the structural features of neuromodels. Then the obtained indicator estimates are compared with the criteria values for choosing the type of structural changes. Variants of mutational changes from the group of methods of neuroevolutionary modification of the topology and weights of the neural network are used as variants of structural change. The method allows to reduce the resource intensity during the operation of neuromodels, by accelerating the processing of big data, which expands the field of practical application of artificial neural networks.
Results. The developed method is implemented and investigated by the example of using a recurrent artificial network of the long short-term memory type when solving the classification problem. The use of the developed method allowed speed up of the neuromodel with a test sample by 25.05%, depending on the computing resources used.
Conclusions. The conducted experiments confirmed the operability of the proposed mathematical software and allow us to recommend it for use in practice in the structural adjustment of pre-synthesized neuromodels for further solving problems of diagnosis, forecasting, evaluation and pattern recognition using big data. The prospects for further research may consist in a more fine-tuning of the indicator system to determine the connections encoding noisy data in order to further improve the accuracy of models based on neural networks.
Relationship between structural changes in paravertebral muscles and the development of spine degenerative diseases
Authors: Radchenko Volodymyr , Ashukina Nataliya , Maltseva Valentyna , Skidanov Mykyta , Skidanov Artem 
Published: October 2021

Based on the systematic approach to the diagnosis of spinal patho­logy, there are no fundamental differences in the etiology of spine degenerative disease, facet joints arthritis, and other diseases. These diseases are considered multifactorial: age (aging), systemic regulatory factors (hormones, peptides, cytokines), genetic predisposition, inadequate physical activity, unfavorable environmental factors, and others lead to pathological changes in the structure of the spinal motor segment components. Recently, much attention has been paid to the paravertebral muscles changes, in which over time, as a result of injuries or degenerative processes, inevitably lead to dysfunction, which can lead to the occurrence of chronic lumbar pain. Objective. To assess the relationship between structural changes in paravertebral muscles and the development of degenerative diseases of the spine on the basis of scientific literature review. It was found that degenerative changes in paravertebral muscles, as components of spinal motor segments, develop with aging. In particular, muscle fibers are replaced by fat tissue, which is more pronounced in women compared to men. A direct correlation between chronic lumbar pain and paravertebral muscle atrophy has been reported. Systemic factors, in particular low levels of vitamin D, also can cause the development of degenerative changes in paravertebral muscles, especially in women. Obesity provokes systemic inflammation, increases fatty infiltration of skeletal muscles and increases sensitivity to pain. Reduced levels of physical activity lead to weakness and atrophy of the paravertebral muscles, which can cause degeneration of the intervertebral disc. At the same time, exercise prior to spinal surgery for degenerative disea­ses improves functional outcomes and reduces pain. Conversely, damage to the paravertebral muscles increase the load on the adjacent to spinal fusion segments. In general, the role of paravertebral muscles in the development of degenerative spinal diseases has not been definitively studied.
The measure of freedom the subject-addressee of genetic education: the content of genetic education
Authors: Voronin M. V. 
Published: October 2021

The article is devoted to the issue of the measure of freedom of the subject-addressee of genetic education. The goal of this article is to clarify and analyze the features of content of genetic education; to compare the notion of genetic education with legal and medical education and find similarities and differences between them; to reflect on ways and methods of legal and social regulation of genetic education.The study considers two theoretical models of understanding of the measure of freedom related to the use of information on genetic data. The first model deals with genetic information that must be provided. The second model pertains to optional information.The notion of “genomic education” is analyzed in the context of characteristics of genetic education and is compared with medical and legal education. It is highlighted that genetic education is inherently innovative, interdisciplinary, narrow-focused, limited in its content, and proactive.In conclusion, it is emphasized that there is a need to conduct a further research on content, control and communication in the implementation of narrow-focused genetic education.
Legal regimes for using human embryos for scientific purposes in the light of the international bodies’ practice
Authors: Gazina N. I. 
Published: October 2021

The research on human embryos evolves rapidly, raising a number of ethical and legal issues and directly affecting human rights. Approaches to the legal regulation of human embryo research differ significantly from country to country. Some of them employ prohibitive practices (e.g. Switzerland and Italy), and the others have a regime that allows using embryos for scientific purposes with restrictions of different extent (e.g. the UK and Japan). There is no the international consensus on the issue of human embryo research. The objective of the article is to find out whether there are positions of the international bodies that may become or have already become the general guidance for different countries, allowing therefore to regulate effectively the use of human embryos for scientific purposes.The conclusion is drawn that there are positions of international bodies that may serve as the guidance within the regulation of the area concerned. States may enjoy a wide margin of appreciation within the framework of human embryo research regulation, considering the need to update their regulations regularly to harmonize them with the development of human rights and scientific progress and also to ensure a certain level of the embryo protection.
Levels IL-4, IL-8, TNF-α in middle-aged men with stented coronary arteries after repeated myocardial revascularization
Authors: Vasilenko Vladimir S. , Kurnikova Elena A. , Gostimskiy Vadim A. , Shenderov Sergey V. , Blinov Aleksandr E. , Varlamova Olga N. , Dement’eva Elena A. 
Published: October 2021

Background. It has now been established that inflammatory cytokines are involved in all the stages of the development of coronary heart disease. It has been scientifically proved that the severity of coronary heart disease directly correlates with the increase in the level of proinflammatory cytokines, while data on the role of proinflammatory interleukin IL-8 and anti-inflammatory interleukin IL-4 are contradictory.
The aim of the study was to evaluate the levels of proinflammatory cytokines (IL-8, TNF-) and anti-inflammatory interleukin (IL-4) in patients with various forms of coronary heart disease who underwent re-stenting of the coronary arteries.
Materials and methods. By the method of enzyme-linked immunosorbent assay, the levels of cytokines were determined in 28 patients who had previously undergone myocardial infarction with stenting of an infarct-related artery, re-admitted due to the development of acute coronary syndrome, who underwent repeated stenting of coronary arteries. The same method was performed on 24 patients who also had previously undergone myocardial infarction with stenting of the infarction-associated artery, who were admitted to the clinic for staged stenting of the coronary arteries.
Results. In patients with chronic coronary syndrome the levels of IL-4 a do not exceed the reference values, in patients with acute coronary syndrome the levels of IL-4 there was an increase 3,700,24 and 359,8066,94 pg/ml, р 0,001. In patients with chronic coronary syndrome the levels of IL-8 a do not exceed the reference values, in patients with acute coronary syndrome the levels of IL-8 there was an increase 7,341,29 and 69,7518,25 pg/ml, р 0,001.
Conclusions. The increase in the level of IL-4 has a compensatory character and, along with a slight increase in TNF-, can be considered as a positive factor stabilizing the course of the disease.
Amelogenesis imperfecta: A case series
Authors: Jijin M J  , Thabsheera P P  , Labeeb K P Mohamed , Anjana R  
Published: October 2021

Amelogenesis imperfecta (AI) refers to a group of rare genetic disorders that involve tooth development and that are passed down through families as a dominant trait. This condition is characterized by abnormal enamel formation caused by gene mutations that alter the quality and/or quantity of enamel. This dental problem can impact both primary and permanent dentition, varies among affected individuals, and results in esthetic and functional problems. The treatment planning for patients with AI is related to many factors, including the age of the patient, the type and severity of the disorder, intraoral conditions, and the socioeconomic status of the patient. It is crucial to plan a proper remedy, which requires collaboration among dental specialties to execute comprehensive dental treatment in order to provide a long-term solution with adequate esthetics. This clinical case study looks at three different types of amelogenesis imperfecta patients.
AN ASSESSMENT OF THE FINANCIAL AND ECONOMIC SECURITY OF THE AGRICULTURAL SECTOR IN UKRAINE
Authors: Sirenko N. , Lunkina T. , Burkovskaya A. , Mikulyak К. 
Published: October 2021

Abstract. The article states that the financial and economic security of the agricultural sector is aimed at ensuring a sufficient level of efficiency of financial and economic activities; protection from external and internal dangers, improvement of financial firmness, and stability. It is established that one of the ways to solve these problems is the application of modern approaches to determining the level of financial and economic security of agricultural sector entities in order to identify the most significant threats to the market, as well as the application of modern approaches to improving the level of financial and economic security of the Ukrainian agricultural sector.
It was found that the financial security of the country directly and proportionally affects the financial and economic security of the agricultural sector, and the presence of problems can prevent the agricultural sector from reaching the desired economic level. The basic elements of financial and economic security in agricultural entities are identified as financial resources, financial stability (solvency), and profitability of operating activities, effectiveness of financial and economic activities, the possibility and cost of attracting external financial resources. The indicators for financial and economic security of agricultural enterprises in Mykolayiv region are assessed and a model of factors influencing the indicator, which is the profitability of operating activity, is developed.
General and specialist research methods were used to study theoretical, and methodological issues of financial and economic security in the agricultural sector; monographic, causal relationships, and logical modeling are also used in determining the indicators of assessing the level of financial and economic security in the agricultural sector; method of dynamic analysis and — in order to assess the rate of economic growth of the main macroeconomic indicators of the country, taking into account the dynamics of their change in the market environment; calculation-constructive, graphic — when assessing the level of financial and economic security.
It is proved that the financial and economic security of the agricultural sector is aimed at ensuring a sufficient level of efficiency of financial and economic activities in the market environment, protection from external and internal dangers, as well as creating conditions for long-term development, given globalization challenges.
Keywords: agricultural sector, financial security, financial and economic security, indicators, approaches.
JEL Classification Q14, Q18
Formulas: 0; fig.: 1; tabl.: 6; bibl.: 13.
ГРЕКИ В КИЇВСЬКОМУ КОМЕРЦІЙНОМУ ІНСТИТУТІ: ДОСЛІДЖЕННЯ БІОГРАФІЙ СТУДЕНТСЬКОГО ПЕРІОДУ ТА СПРОБИ САМООРГАНІЗАЦІЇ
Authors: Чуткий А. І. 
Published: October 2021

Дослідження побудоване в рамках вивчення студентства Київського комерційного інституту, оскілки його архів становить цінне джерело вивчення українського суспільства початку XX ст. Це обумовлено особливим демократизмом цього вишу в політиці щодо викладацьких кадрів і студентства, зокрема першістю в доступі до вищої освіти представників одразу обох статей, фактичній нівеляції станових та етно-конфесійних обмежень для абітурієнтів тощо. Як результат — його студентство являло концентрований зріз цілого суспільства українських земель, що перебували в складі Російської імперії.
У цій розвідці досліджуються документи з архіву Київського комерційного інституту, що пов’язані з навчанням у ньому греків та справою заснування ними Еллінського (грецького) земляцтва.
Ключові слова: історія України початку XX ст., грецька діаспора, національні меншини, персоналістика, студентські організації.
СОЦІАЛЬНО-ПОБУТОВІ УМОВИ УТРИМАНЦІВ ДИТПРИТУЛКІВ РАДЯНСЬКОЇ УКРАЇНИ В 1920-Х — НА ПОЧАТКУ 1930-Х РР.
Authors: Шугальова І. М. , Молдавський Р. Л. 
Published: October 2021

В статті проаналізовано причини появи численної категорії безпритульних дітей в 1920-х рр., охарактеризовано заходи держави щодо подолання дитячої безпритульності. З’ясовано кроки, які вживали громадські та державні установи для подолання даної ситуації. Визначено причини занедбаного стану дитячих притулків. В умовах господарської розрухи коштів, що виділяла держава, хронічно не вистачало. Бракувало й педагогічних кадрів. У результаті в притулках спостерігалися високий рівень захворювань дітей на інфекційні недуги та дитяча смертність. Тим не менше, в умовах тоталітарної держави всі факти проявів дитячого маргінесу ретельно приховувалися. Було офіційно проголошено про остаточне подолання дитячої безпритульності. На початку 1930-х рр. на державних дітей очікували ще жорстокіші випробовування: в 1931 р. дитячі заклади виведено з-під державного постачання, через що там суттєво зросла смертність.
Ключові слова: дитяча безпритульність, дитячі притулки, патронат, соціально-побутові умови.
Adipose Tissue Radiodensity in Chronic Diseases: A Literature Review of the Applied Methodologies
Authors: Monirujjaman Md , Martin Lisa , Stretch Cynthia , Mazurak Vera C. 
Published: October 2021

Abstract

Background:
The concept of adipose tissue radiodensity is emerging and its relationship to disease prognosis has been infrequently explored. The aims of the present study were to evaluate published literature that explored adipose tissue radiodensity in relation to outcomes in health and disease and to summarize methodologies used to evaluate adipose tissue radiodensity by computed tomography (CT).

Methods:
A comprehensive literature review included all published studies that applied CT imaging of the abdominal region to define adipose tissue radiodensity. The review was performed without regard for study design or quality.

Results:
We identified 22 studies that evaluated the relationship between adipose tissue radiodensity and outcomes. The literature reviewed highlights significant methodological variation in terms of abdominal region selected, slice thickness, contrast media, dose, software, and radiodensity ranges used to define adipose tissues. This is primarily due to a lack of consensus about the effect such methodological variables have on body composition parameters.

Conclusions:
Authors should carefully report adipose tissue radiodensity, especially when it comes to prognosis inference. Consensus on methodology will enable meaningful advancement in understanding the importance of adipose tissue radiodensity in different disease conditions.
Pengaruh Model Pembelajaran Kooperatif Tipe Teams Games Tournament (TGT) pada Pembelajaran Jarak Jauh terhadap Kemampuan Penalaran Matematis Siswa SMP Negeri 7 Jakarta
Authors: Hamidah Anisatul , Tri Murdiyanto  , Lukman El Hakim  
Published: October 2021

Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh model pembelajaran kooperatif tipe Teams Games Tournament (TGT) pada pembelajaran jarak jauh terhadap kemampuan penalaran matematis siswa SMP Negeri 7 Jakarta dan untuk mengetahui besar pengaruh signifikan dari penerapan model pembelajaran kooperatif tipe Teams Games Tournament (TGT) terhadap kemampuan penalaran matematis siswa di SMP Negeri 7 Jakarta. Metode penelitian yang digunakan adalah metode eksperimen semu. Instrumen penelitian yang digunakan adalah instrumen tes kemampuan penalaran matematis berupa 5 soal uraian yang telah dinyatakan valid dan reliabel. Populasi target penelitian adalah seluruh peserta didik SMP Negeri 7 Jakarta. Populasi terjangkau penelitian adalah siswa kelas VII SMP Negeri 7 Jakarta. Teknik pengambilan sampel menggunakan teknik simple random sampling untuk menentukan kelas eksperimen (model pembelajaran kooperatif tipe Teams Games Tournament) dan kelas kontrol (model pembelajaran konvensional). Berdasarkan uji prasyarat analisis data setelah perlakuan, data pada kedua kelas berdistribusi normal dan memiliki varians yang tidak homogen. Pengujian hipotesis statistik uji-t' pada taraf signifikansi a = 0,05, diperoleh thitung = 3,041 lebih tinggi dari nilai kritis = 1,686, maka H0 ditolak dan diperoleh kesimpulan bahwa rata-rata skor tes kemampuan penalaran matematis siswa kelas eksperimen lebih tinggi dari kelas kontrol. Besar pengaruh pada perhitungan Cohen’s Effect Size (ES), diperoleh ES = 0,684 dengan percent of Non Overlap sebesar 38,2% yang dikategorikan medium. Hal ini menunjukkan bahwa terdapat pengaruh signifikan dari penerapan model pembelajaran kooperatif tipe Teams Games Tournament (TGT) pada pembelajaran jarak jauh terhadap kemampuan penalaran matematis siswa SMP Negeri 7 Jakarta.