bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health outcomes of ICU and non-ICU healthcare workers during the COVID-19 outbreak: a cross-sectional study
Authors: Wozniak Hannah , Benzakour Lamyae , Moullec Grégory , Buetti Niccolò , Nguyen Alice , Corbaz Sandrine , Roos Pauline , Vieux Laure , Suard Jean-Claude , Weissbrodt Rafaël , Pugin Jérôme , Pralong Jacques A. , Cereghetti Sara 
Published: July 2021

Abstract
Background
Intensive care workers are known for their stressful work environment and for a high prevalence of mental health outcomes. The aim of this study was to evaluate the mental health, well-being and changes in lifestyle among intensive care unit (ICU) healthcare workers (HCW) during the first wave of the COVID-19 pandemic and to compare these results with those of HCW in other hospital units. Another objective was to understand which associated factors aggravate their mental health during the COVID-19 outbreak.

Methods
This cross-sectional survey collected socio-demographic data, lifestyle changes and mental health evaluations as assessed by the Generalized Anxiety Disorder 7 items (GAD-7), the Patient Health Questionnaire 9 items (PHQ-9), the Peritraumatic Distress Inventory (PDI) and the World Health Organization Well-Being Index (WHO-5) from the 28th May to 7th July 2020. The study was carried out at Geneva University Hospitals, a group of eight public hospitals in Switzerland. ICU HCW were analyzed for mental health outcomes and lifestyles changes and then compared to non-ICU HCW. A series of linear regression analyses were performed to assess factors associated with mental health scores.

Results
A total of 3461 HCW were included in the study, with 352 ICU HCW. Among ICU HCW, 145 (41%) showed low well-being, 162 (46%) symptoms of anxiety, 163 (46%) symptoms of depression and 76 (22%) had peritraumatic distress. The mean scores of GAD-7, PHQ-9 and WHO-5 were worse in ICU HCW than in non-ICU HCW (p < 0.01). Working in the ICU rather than in other departments resulted in a change of eating habits, sleeping patterns and alcohol consumption (p < 0.01). Being a woman, the fear of catching and transmitting COVID-19, anxiety of working with COVID-19 patients, work overload, eating and sleeping disorders as well as increased alcohol consumption were associated with worse mental health outcomes.

Conclusion
This study confirms the suspicion of a high prevalence of anxiety, depression, peritraumatic distress and low well-being during the first COVID-19 wave among HCW, especially among ICU HCW. This allows for the identification of associated risk factors. Long-term psychological follow-up should be considered for HCW.
Analysis of fractional differential equations with fractional derivative of generalized Mittag-Leffler kernel
Authors: Al-Refai Mohammed , Aljarrah Abdalla , Abdeljawad Thabet 
Published: July 2021

AbstractIn this paper, we study classes of linear and nonlinear multi-term fractional differential equations involving a fractional derivative with generalized Mittag-Leffler kernel. Estimates of fractional derivatives at extreme points are first obtained and then implemented to derive new comparison principles for related linear equations. These comparison principles are used to analyze the solutions of the linear multi-term equations, where norm estimates of solutions, uniqueness and several comparison results are established. For the nonlinear problem, we apply the Banach fixed point theorem to establish the existence of a unique solution.
Energy-aware adaptive offloading of soft real-time jobs in mobile edge clouds
Authors: Silva Joaquim , Marques Eduardo R. B. , Lopes Luís M.B. , Silva Fernando 
Published: July 2021

AbstractWe present a model for measuring the impact of offloading soft real-time jobs over multi-tier cloud infrastructures. The jobs originate in mobile devices and offloading strategies may choose to execute them locally, in neighbouring devices, in cloudlets or in infrastructure cloud servers. Within this specification, we put forward several such offloading strategies characterised by their differential use of the cloud tiers with the goal of optimizing execution time and/or energy consumption. We implement an instance of the model using Jay, a software framework for adaptive computation offloading in hybrid edge clouds. The framework is modular and allows the model and the offloading strategies to be seamlessly implemented while providing the tools to make informed runtime offloading decisions based on system feedback, namely through a built-in system profiler that gathers runtime information such as workload, energy consumption and available bandwidth for every participating device or server. The results show that offloading strategies sensitive to runtime conditions can effectively and dynamically adjust their offloading decisions to produce significant gains in terms of their target optimization functions, namely, execution time, energy consumption and fulfilment of job deadlines.
Occurrence of Aflatoxin B1, deoxynivalenol and zearalenone in feeds in China during 2018–2020
Authors: Zhao Ling , Zhang Lei , Xu Zijian , Liu Xingda , Chen Liyuan , Dai Jiefan , Karrow Niel Alexander , Sun Lvhui 
Published: July 2021

Abstract
Background
The current study was conducted to investigate the individual and combined occurrence of aflatoxin B1 (AFB1), deoxynivalenol (DON) and zearalenone (ZEN) in feeds from various Provinces of China during 2018 to 2020. A total of 3,507 feed samples, including 2,090 feed ingredients and 1,417 complete feed samples, were collected from different areas of China for mycotoxins analysis.

Results
The individual contamination of AFB1, DON and ZEN were present in more than 81.9%, 96.4% and 96.9% of feed samples, respectively, with average concentration ranges of AFB1 between 1.2–27.4 μg/kg, DON between 458.0–1,925.4 μg/kg and ZEN between 48.1–326.8 μg/kg. Notably, 0.9%, 0.5% and 0.1% of feed ingredients, and 1.2–12.8%, 0.9–2.9% and 0–8.9% of complete feeds for pigs, poultry and ruminants with AFB1, ZEN and DON that exceeded China’s safety standards, respectively. Moreover, more than 81.5% of feed ingredients and 95.7% of complete feeds were co-contaminated with various combinations of these mycotoxins.

Conclusion
This study indicates that the feeds in China were universally contaminated with AFB1, DON and ZEN during the past 3 years. These findings highlight the significance of monitoring mycotoxin contaminant levels in the domestic animal feed, and the importance of carrying out feed administration and remediation strategies for mycotoxin control.
Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development
Authors: Yao Yiyi , Li Fenglin , Huang Jiansong , Jin Jie , Wang Huafeng 
Published: July 2021

AbstractDespite the advances in intensive chemotherapy regimens and targeted therapies, overall survival (OS) of acute myeloid leukemia (AML) remains unfavorable due to inevitable chemotherapy resistance and high relapse rate, which mainly caused by the persistence existence of leukemia stem cells (LSCs). Bone marrow microenvironment (BMM), the home of hematopoiesis, has been considered to play a crucial role in both hematopoiesis and leukemogenesis. When interrupted by the AML cells, a malignant BMM formed and thus provided a refuge for LSCs and protecting them from the cytotoxic effects of chemotherapy. In this review, we summarized the alterations in the bidirectional interplay between hematopoietic cells and BMM in the normal/AML hematopoietic environment, and pointed out the key role of these alterations in pathogenesis and chemotherapy resistance of AML. Finally, we focused on the current potential BMM-targeted strategies together with future prospects and challenges. Accordingly, while further research is necessary to elucidate the underlying mechanisms behind LSC–BMM interaction, targeting the interaction is perceived as a potential therapeutic strategy to eradicate LSCs and ultimately improve the outcome of AML.
Inclement weather forces stopovers and prevents migratory progress for obligate soaring migrants
Authors: Mallon Julie M. , Bildstein Keith L. , Fagan William F. 
Published: July 2021

AbstractBackgroundMigrating birds experience weather conditions that change with time, which affect their decision to stop or resume migration. Soaring migrants are especially sensitive to changing weather conditions because they rely on the availability of environmental updrafts to subsidize flight. The timescale that local weather conditions change over is on the order of hours, while stopovers are studied at the daily scale, creating a temporal mismatch.MethodsWe used GPS satellite tracking data from four migratory Turkey Vulture (Cathartes aura) populations, paired with local weather data, to determine if the decision to stopover by migrating Turkey Vultures was in response to changing local weather conditions. We analyzed 174 migrations of 34 individuals from 2006 to 2019 and identified 589 stopovers based on variance of first passage times. We also investigated if the extent of movement activity correlated with average weather conditions experienced during a stopover, and report general patterns of stopover use by Turkey Vultures between seasons and across populations.ResultsStopover duration ranged from 2 h to more than 11 days, with 51 % of stopovers lasting < 24 h. Turkey Vultures began stopovers immediately in response to changes in weather variables that did not favor thermal soaring (e.g., increasing precipitation fraction and decreasing thermal updraft velocity) and their departure from stopovers was associated with improvements in weather that favored thermal development. During stopovers, proportion of activity was negatively associated with precipitation but was positively associated with temperature and thermal updraft velocity.ConclusionsThe rapid response of migrating Turkey Vultures to changing weather conditions indicates weather-avoidance is one of the major functions of their stopover use. During stopovers, however, the positive relationship between proportion of movement activity and conditions that promote thermal development suggests not all stopovers are used for weather-avoidance. Our results show that birds are capable of responding rapidly to their environment; therefore, for studies interested in external drivers of weather-related stopovers, it is essential that stopovers be identified at fine temporal scales.
An empirical study on the evaluation of the RDF storage systems
Authors: Ben Mahria Bilal , Chaker Ilham , Zahi Azeddine 
Published: July 2021

AbstractIn this paper, we introduce three new implementations of non-native methods for storing RDF data. These methods named RDFSPO, RDFPC and RDFVP, are based respectively on the statement table, property table and vertical partitioning approaches. As important, we consider the issue of how to select the most relevant strategy for storing the RDF data depending on the dataset characteristics. For this, we investigate the balancing between two performance metrics, including load time and query response time. In this context, we provide an empirical comparative study between on one hand the three proposed methods, and on the other hand the proposed methods versus the existing ones by using various publicly available datasets. Finally, in order to further assess where the statistically significant differences appear between studied methods, we have performed a statistical analysis, based on the non-parametric Friedman test followed by a Nemenyi post-hoc test. The obtained results clearly show that the proposed RDFVP method achieves highly competitive computational performance against other state-of-the-art methods in terms of load time and query response time.
Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin
Authors: Ohkubo Takayuki , Kurihara Yusuke , Ogawa Masanao , Nengaki Nobuki , Fujinaga Masayuki , Mori Wakana , Kumata Katsushi , Hanyu Masayuki , Furutsuka Kenji , Hashimoto Hiroki , Kawamura Kazunori , Zhang Ming-Rong 
Published: July 2021

Abstract
Background
[18F]Fluoromisonidazole ([18F]FMISO) and 1-[18F]fluoro-3-((2-((1E,3E)-4-(6-(methylamino)pyridine-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol ([18F]PM-PBB3 or [18F]APN-1607) are clinically used radiotracers for imaging hypoxia and tau pathology, respectively. Both radiotracers were produced by direct 18F-fluorination using the corresponding tosylate precursors 1 or 2 and [18F]F−, followed by the removal of protecting groups. In this study, we synthesized [18F]FMISO and [18F]PM-PBB3 by 18F-fluoroalkylation using [18F]epifluorohydrin ([18F]5) for clinical applications.

Results
First, [18F]5 was synthesized by the reaction of 1,2-epoxypropyl tosylate (8) with [18F]F− and was purified by distillation. Subsequently, [18F]5 was reacted with 2-nitroimidazole (6) or PBB3 (7) as a precursor for 18F-labeling, and each reaction mixture was purified by preparative high-performance liquid chromatography and formulated to obtain the [18F]FMISO or [18F]PM-PBB3 injection. All synthetic sequences were performed using an automated 18F-labeling synthesizer. The obtained [18F]FMISO showed sufficient radioactivity (0.83 ± 0.20 GBq at the end of synthesis (EOS); n = 8) with appropriate radiochemical yield based on [18F]F− (26 ± 7.5 % at EOS, decay-corrected; n = 8). The obtained [18F]PM-PBB3 also showed sufficient radioactivity (0.79 ± 0.10 GBq at EOS; n = 11) with appropriate radiochemical yield based on [18F]F− (16 ± 3.2 % at EOS, decay-corrected; n = 11).

Conclusions
Both [18F]FMISO and [18F]PM-PBB3 injections were successfully synthesized with sufficient radioactivity by 18F-fluoroalkylation using [18F]5.
From statistics to clinics: the visual feedback of PROMIS® CATs
Authors: van Muilekom Maud M. , Luijten Michiel A. J. , van Oers Hedy A. , Terwee Caroline B. , van Litsenburg Raphaële R. L. , Roorda Leo D. , Grootenhuis Martha A. , Haverman Lotte 
Published: July 2021

Abstract
Background
To reduce the burden of completing Patient-Reported Outcome Measures (PROMs), PROMIS® Computerized Adaptive Tests (CATs) are being implemented in pediatric clinical practice. We aimed to develop recommendations for visual feedback options for PROMIS CATs on individual item and domain score level as an evidence-based feedback recommendation for PROMIS CATs is lacking.

Methods
Focus groups were held with clinicians who use the KLIK PROM portal. Literature-based feedback options were provided to initiate group discussion. Data was analyzed using thematic coding method. Additionally, a questionnaire was sent out to assess patients’ (12-18y) and parents’ (child 0-18y) preference for individual item feedback. Data was analyzed using descriptive statistics.

Results
Six focus groups were held (N = 28 clinicians). Regarding individual item feedback, showing the complete item bank, with only responses to administered items in traffic light colors was preferred. For domain scores, line graphs were preferred, including numerical (T-)scores, reference and cut-off lines, and traffic light colors. Separate graphs per domain, ranked in order of importance and harmonization of directionality (‘higher = better’) were considered important. Questionnaire results (N = 31 patients/N = 131 parents) showed that viewing their own item responses was preferred above receiving no item feedback by 58.1% of the patients and 77.1% of the parents.

Conclusions
Based on the outcomes and after discussion with the Dutch-Flemish PROMIS National Center, recommendations for PROMIS CAT feedback options were developed. PROMIS CATs can now be used in clinical practice to help clinicians monitor patient outcomes, while reducing the burden of completing PROMs for patients significantly.
Development of a short form of the Singapore Caregiver Quality of Life Scale – Dementia: SCQOLS-D-15
Authors: Lee Chun Fan , Seow Dennis C. C. , Teo Irene , Neo Shirlyn H. S. , Yang Grace M. , Lee Geok Ling , Lim Wee Shiong , Hum Allyn , Cheung Yin Bun 
Published: July 2021

Abstract
Purpose
The Singapore Caregiver Quality of Life Scale – Dementia (SCQOLS-D), developed based on the Singapore Caregiver Quality of Life Scale (SCQOLS), comprises 5 domains and 63 items. It has been shown to be a valid and reliable measurement scale. This study aimed to develop and evaluate a short form of the SCQOLS-D.

Methods
Data were collected from 102 family caregivers of person with dementia in Singapore. Candidate items were shortlisted by factor analysis, correlation and best subset regression. Shortlisted items with the best measurement properties including correlations with the long form and other established measures, internal consistency and test-retest reliability were identified. Their properties were compared with the corresponding domain scores in the long form of SCQOLS-D and a short form of the SCQOLS. A total score based on the average of the domain scores was also evaluated.

Results
A total of fifteen items, two to four items per domain, were selected. The total and domain scores generated from these items strongly correlated with the corresponding score of the long form (correlation coefficients: 0.83–0.97). The short and long forms had comparable correlation coefficients with Negative Personal Impact and Positive Personal Impact measures. The short form showed good internal consistency (Cronbach’s alpha: 0.84–0.92) and test-retest reliability (intra-class correlation coefficient: 0.72–0.93). These 15 items form the SCQOLS-D-15, an abbreviated version of the SCQOLS-D.

Conclusion
The SCQOLS-D-15 showed acceptable measurement properties. This serves as an alternative to the SCQOLS-D to provide rapid assessment of the overall and domain-specific quality of life of caregivers of persons with dementia.
Direct puncture of an occluded common femoral artery as a new approach for endovascular aortic aneurysm repair
Authors: Ichihashi Shigeo , Yamamoto Tsunehisa , Bolstad Francesco , Koshi Keitarou 
Published: July 2021

Abstract
Background
Abdominal aortic aneurysms (AAA) which present with a hostile access are not uncommon. When an arterial occlusion continuously involves from the iliac to the femoropopliteal artery, endovascular aneurysm repair (EVAR) can become complex, necessitating an adjunctive surgical procedure. The present report outlines a successful EVAR which was conducted without any adjunctive surgical procedure for an AAA complicated by extensive access vessel occlusion.

Case presentation
The patient, an 82-year-old male, had a fusiform 50 mm infrarenal AAA. He had a history of above knee amputation of the right leg due to a gangrene from Buerger’s Disease. Despite the continuous occlusions of the right external iliac artery (EIA), common femoral artery (CFA), and superficial femoral and profunda femoris artery, limb ischemia was not observed in his right leg. Since revascularization of the occluded right iliac and femoral arteries was deemed to be too complex technically and no ischemic symptoms were observed, EVAR was performed using the occluded access only for the delivery of the stent graft without restoring the flow. Firstly, the occluded right CFA was punctured under ultrasound guidance. Next, a 0.014 in. guidewire and a microcatheter were successfully navigated to the subintimal space of the right common iliac artery (CIA), these were then exchanged with a reentry device. The reentry device allowed the advancement of a guidewire into the true lumen of the right CIA. Then, a 12Fr sheath for delivery of a contralateral limb was advanced via the occluded right access to aorta, and a 16 Fr sheath for delivery of a main body graft was advanced via a patent left iliac artery. A standard EVAR procedure was subsequently performed.

Conclusions
EVAR was successfully performed for an AAA complicated with an arterial occlusion from the EIA to the SFA using direct puncture of the occluded CFA. This technique could be an effective measure for cases with a hostile access involving the CFA.
Achieving the HbA1c Target Requires Longer Time in Range in Pregnant Women With Type 1 Diabetes
Authors: Ling Ping , Yang Daizhi , Gu Nan , Xiao Xinhua , Lu Jing , Liu Fang , Zhou Zhiguang , Huang Qin , Zhao Jiajun , Zhang Mei , Hu Ji , Luo Sihui , Weng Jianping , Yan Jinhua , Zheng Xueying 
Published: July 2021

AbstractContextContinuous glucose monitoring (CGM) overcomes the limitations of glycated hemoglobin (HbA1c).ObjectiveThis study aimed to investigate the relationship between CGM metrics and laboratory HbA1c in pregnant women with type 1 diabetes.MethodsAn observational study enrolled pregnant women with type 1 diabetes who wore CGM devices during pregnancy and postpartum from 11 hospitals in China from January 2015 to June 2019. CGM data were collected to calculate time in range (TIR), time above range (TAR), time below range (TBR), and glycemic variability parameters. Relationships between the CGM metrics and HbA1c were explored. Linear and curvilinear regressions were conducted to investigate the best-fitting model to clarify the influence of HbA1c on the TIR-HbA1c relationship during pregnancy.ResultsA total of 272 CGM data and corresponding HbA1c from 98 pregnant women with type 1 diabetes and their clinical characteristics were analyzed in this study. Mean HbA1c and TIR were 6.49 ± 1.29% and 76.16 ± 17.97% during pregnancy, respectively. HbA1c was moderately correlated with TIR3.5-7.8(R = –0.429, P = .001), mean glucose (R = 0.405, P = .001) and TAR7.8 (R = 0.435, P = .001), but was weakly correlated with TBR3.5 (R = 0.034, P = .001) during pregnancy. On average, a 1% (11 mmol/mol) decrease in HbA1c corresponded to an 8.5% increase in TIR3.5–7.8. During pregnancy, HbA1c of 6.0%, 6.5%, and 7.0% were equivalent to a TIR3.5–7.8 of 78%, 74%, and 69%, respectively.ConclusionWe found there was a moderate correlation between HbA1c and TIR3.5–7.8 during pregnancy. To achieve the HbA1c target of less than 6.0%, pregnant women with type 1 diabetes should strive for a TIR3.5–7.8 of greater than 78% (18 hours 43 minutes) during pregnancy.
Modification of Surface Roughness and Area of FeCrAl Substrate for Catalytic Converter using Ultrasonic Treatment
Authors: Putrasari Yanuandri , Untoro P , Hasan Sulaiman , Huda Naili , Sebayang Darwin 
Published: July 2021

Surface roughness and area play important role especially in deposition and reaction of the catalyst in the catalytic converter substrate. The aim of this paper is to show the modification of surface roughness and area of FeCrAl substrate for catalytic converter using ultrasonic method. The method was conducted by agitating the FeCrAl in 10 minutes 35 kHz ultrasonic cleaning bath. The surface roughness, morphology, and chemical components of FeCrAl catalytic converter substrate after ultrasonic treatment were analyzed using atomic force microscope (AFM) and examined with scanning electron microscope (SEM) in combination with energy dispersive X-ray spectroscopy (EDS). The ultrasonic treatment assisted with Al2O3 powders successfully increased the roughness and surface area of FeCrAl better than SiC powders.