bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designing Polymer‐in‐Salt Electrolyte and Fully Infiltrated 3D Electrode for Integrated Solid‐State Lithium Batteries
Authors: Liu Wenyi , Yi Chengjun , Li Linpo , Liu Shuailei , Gui Qiuyue , Ba Deliang , Li Yuanyuan , Peng Dongliang , Liu Jinping 
Published: April 2021

AbstractSolid‐state lithium batteries (SSLBs) are promising owing to enhanced safety and high energy density but plagued by the relatively low ionic conductivity of solid‐state electrolytes and large electrolyte–electrode interfacial resistance. Herein, we design a poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVDF‐HFP)‐based polymer‐in‐salt solid electrolyte (PISSE) with high room‐temperature ionic conductivity (1.24×10−4 S cm−1) and construct a model integrated TiO2/Li SSLB with 3D fully infiltration of solid electrolyte. With forming aggregated ion clusters, unique ionic channels are generated in the PISSE, providing much faster Li+transport than common polymer electrolytes. The integrated device achieves maximized interfacial contact and electrochemical and mechanical stability, with performance close to liquid electrolyte. A pouch cell made of 2 SSLB units in series shows high voltage plateau (3.7 V) and volumetric energy density comparable to many commercial thin‐film batteries.
Simple Non‐Fused Electron Acceptors Leading to Efficient Organic Photovoltaics
Authors: Wen Tian‐Jiao , Liu Zhi‐Xi , Chen Zeng , Zhou Jiadong , Shen Ziqiu , Xiao Yiqun , Lu Xinhui , Xie Zengqi , Zhu Haiming , Li Chang‐Zhi , Chen Hongzheng 
Published: April 2021

AbstractDespite the remarkable progress achieved in recent years, organic photovoltaics (OPVs) still need work to approach the delicate balance between efficiency, stability, and cost. Herein, two fully non‐fused electron acceptors, PTB4F and PTB4Cl, are developed via a two‐step synthesis from single aromatic units. The introduction of a two‐dimensional chain and halogenated terminals for these non‐fused acceptors plays a synergistic role in optimizing their solid stacking and orientation, thus promoting an elongated exciton lifetime and fast charge‐transfer rate in bulk heterojunction blends. As a result, PTB4Cl, upon blending with PBDB‐TF polymer, has enabled single‐junction OPVs with power conversion efficiencies of 12.76 %, representing the highest values among the reported fully unfused electron acceptors so far.
Water recovery from flue gas using polyether block amide 2533/sulfonated poly(ether ether ketone) composite membrane
Authors: Zhang Zhichao , Wang Wei , Liu Xi , Li Yuanling , Zhang Peng , Shi Yaping , Xu Xin 
Published: April 2021

AbstractRecycling water from flue gas of coal‐fired power plants is of great significance to save energy and water resources and reduce environmental pollution. In the present work, two potential polymers (polyether block amide 2533(PEBAX 2533) and sulfonated poly(ether ether ketone) (SPEEK)) were investigated and showed high water vapor permeability and selectivity, respectively. Combined with the advantages of the two materials, a novel PEBAX 2533/SPEEK composite membrane with an ultra‐thin SPEEK selection layer on the outer surface of the high permeable PEBAX 2533 layer was prepared by dip coating. The composite membranes were assembled into a membrane capsule module and tested directly in artificial and real flue gas. The condensed water vapor fluxes were 1006.9 g/m2.h in artificial flue gas and 600–900 g/m2.h on average in real flue gas during a period of 30 days, exhibiting good water vapor permeability and durability in real flue gas.
Fast heuristic approach for control of complex authentication systems
Authors: Toragay Oguz , Silva Daniel F. 
Published: April 2021

AbstractIn secure networks, the authentication process, which verifies a user's identity, is a sensitive operation. Balancing the authentication process's security and usability while keeping operating costs low is a major challenge. We investigate this process in a secure system that has multiple authentication methods available. The goal is to find a fast and easy‐to‐implement approach to assign incoming requests to authentication methods in a way that balances cost, usability, and security. We model the system as a continuous‐time, infinite‐horizon Markov Decision Process. Then, we propose a new, fast heuristic approach to solve the problem, as the curse of dimensionality limits the effectiveness of exact methods. The proposed heuristic uses closed‐form approximations to define threshold policies that are easily implementable. Numerical experiments show that our approach yields robust, near‐optimal solutions, with high accuracy, for a wide range of problem instances.
Advances in biochemistry and the biotechnological production of taxifolin and its derivatives
Authors: Thuan Nguyen Huy , Shrestha Anil , Trung Nguyen Thanh , Tatipamula Vinay Bharadwaj , Van Cuong Duong , Canh Nguyen Xuan , Van Giang Nguyen , Kim Tae‐Su , Sohng Jae Kyung , Dhakal Dipesh 
Published: April 2021

AbstractTaxifolin (dihydroquercetin) and its derivatives are medicinally important flavanonols with a wide distribution in plants. These compounds have been isolated from various plants, such as milk thistle, onions, french maritime, and tamarind. In general, they are commercially generated in semisynthetic forms. Taxifolin and related compounds are biosynthesized via the phenylpropanoid pathway, and most of the biosynthetic steps have been functionally characterized. The knowledge gained through the detailed investigation of their biosynthesis has provided the foundation for the reconstruction of biosynthetic pathways. Plant‐ and microbial‐based platforms are utilized for the expression of such pathways for generating taxifolin‐related compounds, either by whole‐cell biotransformation or through reconfiguration of the genetic circuits. In this review, we summarize recent advances in the biotechnological production of taxifolin and its derivatives.
Supramolecular Interaction of Molecular Cage and β‐Galactosidase: Application in Enzymatic Inhibition, Drug Delivery and Antimicrobial Activity
Authors: Mondal Avijit , Bhat Imtiyaz Ahmad , Karunakaran Subbaraj , De Mrinmoy 
Published: April 2021

AbstractEnzyme inhibitors play a crucial role in diagnosis of a wide spectrum of diseases related to bacterial infections. We report here the effect of a water‐soluble self‐assembled PdII8 molecular cage towards β‐galactosidase enzyme activity. The molecular cage is composed of a tetrapyridyl donor (L) and cis‐[(en)Pd(NO3)2] (en=ethane‐1,2‐diamine) acceptor and it has a hydrophobic internal cavity. We have observed that the acceptor moiety mainly possesses the ability to inactivate the β‐galactosidase enzyme activity. Kinetic investigation revealed the mixed mode of inhibition. This inhibition strategy was extended to control the growth of methicillin‐resistant Staphylococcus aureus. The internalization of the Pd(II) cage inside the bacteria was confirmed when bacterial solutions were incubated with curcumin loaded cage. The intrinsic green fluorescence of curcumin made the bacteria glow when put under an optical microscope. Furthermore, this curcumin loaded molecular cage shows an enhanced antibacterial activity. Thus, PdII8 molecular cage is quite attractive due to its dual role as enzyme inhibitor and drug carrier.
A longitudinal case series of IM ketamine for patients with severe and enduring eating disorders and comorbid treatment‐resistant depression
Authors: Schwartz Terry , Trunko Mary Ellen , Feifel David , Lopez Emily , Peterson Danika , Frank Guido K. W. , Kaye Walter 
Published: April 2021

AbstractSevere and enduring eating disorders (EDs) have the highest mortality rate of all psychiatric illnesses (Arch Gen Psychiatry, 2011, 68, 724), especially when comorbid with treatment‐resistant depression (TRD) (Psychiatr Res, 2016, 244, 45). We report on four patients with enduring EDs and TRD treated with repeat ketamine over 12 + months, showing improvement in depression with only modest changes in ED symptoms.
L'effet persuasif de l'intégration du prénom et de la photographie d'employés potentiels dans une publicité de recrutement
Authors: Pfiffelmann Jean , Soulez Sébastien 
Published: April 2021

AbstractWhile targeting job postings is a common practice for recruiters, they can now personalize their ads by embedding the recipients' names and photographs in the advertisement. Research shows divergent results on the effects of personalization. This experiment, conducted among 236 participants, assesses the combined effect of recruitment advertisement personalization and job targeting on attitudinal reactions. Our results show that personalization and targeting help increase self‐referencing, which in turn positively influences the attitude about the advertisement, click intention, and job‐pursuit intention. However, personalization has a negative main effect on these attitudinal reactions.
PM10 Concentration, Its Potentially Toxic Metals Content, and Human Health Risk Assessment in Hamadan, Iran
Authors: Joshirvani Amad , Samarghandi Mohammad Reza , Leili Mostafa 
Published: April 2021

AbstractThis study aims to determine the health risks from some potentially toxic metal content of PM10 on the residents of Hamadan, Iran. The mean concentration of PM10 is 122.55 µg m–3, and for Pb, Cd, and Cr it is 7.44, 1.78, and 2.72 ng m–3, respectively. PM10 levels of 22% of the samples are higher than the National Ambient Air Quality Standards (NAAQS). Pb and Cd levels are within the standard/guideline limits, whereas Cr levels exceed the guideline value in 53% of the samples. Health risks from toxic elements of PM10 are estimated using hazard quotient (HQ) and hazard index (HI), and the cancer risk is evaluated based on lifetime daily cancer risk (CR). Both HQ and HI are <1; furthermore, children are at an increased health risk according to obtained HQ and HI values. Cr and Cd present potentially carcinogenic health risks, while CR from Pb is within the acceptable limits. Although both HQ and HI are obtained <1, conducting such health risk assessment studies really is needed to determine the air quality in different cities such as Hamadan and the obtained data can be used as general guidance for decision makers to manage the air quality.
Inspecting the Mechanism of Fragment Hits Binding on SARS‐CoV‐2 Mpro by Using Supervised Molecular Dynamics (SuMD) Simulations
Authors: Bissaro Maicol , Bolcato Giovanni , Pavan Matteo , Bassani Davide , Sturlese Mattia , Moro Stefano 
Published: April 2021

AbstractComputational approaches supporting the early characterization of fragment molecular recognition mechanism represent a valuable complement to more expansive and low‐throughput experimental techniques. In this retrospective study, we have investigated the geometric accuracy with which high‐throughput supervised molecular dynamics simulations (HT‐SuMD) can anticipate the experimental bound state for a set of 23 fragments targeting the SARS‐CoV‐2 main protease. Despite the encouraging results herein reported, in line with those previously described for other MD‐based posing approaches, a high number of incorrect binding modes still complicate HT‐SuMD routine application. To overcome this limitation, fragment pose stability has been investigated and integrated as part of our in‐silico pipeline, allowing us to prioritize only the more reliable predictions.
Brain‐wide mapping of presynaptic inputs to basolateral amygdala neurons
Authors: Morikawa Shota , Katori Kazuki , Takeuchi Haruki , Ikegaya Yuji 
Published: April 2021

AbstractThe basolateral amygdala (BLA), a region critical for emotional processing, is the limbic hub that is connected with various brain regions. BLA neurons are classified into different subtypes that exhibit differential projection patterns and mediate distinct emotional behaviors; however, little is known about their presynaptic input patterns. In this study, we employed projection‐specific monosynaptic rabies virus tracing to identify the direct monosynaptic inputs to BLA subtypes. We found that each neuronal subtype receives long‐range projection input from specific brain regions. In contrast to their specific axonal projection patterns, all BLA neuronal subtypes exhibited relatively similar input patterns. This anatomical organization supports the idea that the BLA is a central integrator that associates sensory information in different modalities with valence and sends associative information to behaviorally relevant brain regions.
Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta‐analysis
Authors: Roomaney Imaan Amina , Holmes Haly Karen , Engel Mark E. 
Published: April 2021

AbstractObjectivesThis systematic review evaluated the evidence for the effectiveness of Photodynamic therapy (PDT) in treating oral fungal infections, as an alternative to conventional antifungal medications.MethodsFive randomized control trials (168 participants) comparing the treatment of oral fungal infections using met with our inclusion criteria. Clinical and microbiological improvement was assessed by random‐effects meta‐analysis. Methodological quality assessment and heterogeneity were performed using peer‐reviewed criteria. PROSPERO registration: CRD42017076.ResultsPDT showed statistically non‐significant increased clinical efficacy (risk ratio (RR) = 1.47 [95% confidence interval (CI), 0.68; 3.17]; three studies, n = 108 participants, I2 = 50%) and mycological efficacy (mean difference (MD) = 0.54 [95%CI, −0.71; 1.79]; three studies, n = 100; I2 = 39%) at 30 days, as compared with conventional antifungal therapy. Lack of standardization of treatment parameters and variability in the assessment of outcomes was observed across the studies. All included studies had a moderate to low risk of bias.ConclusionsPDT showed comparable effectiveness at treating oral fungal infections, particularly denture stomatitis. The small number of studies in this review, small sample size and variability of methods and outcome measures across studies, highlight the need for more standardized studies with longer follow‐up periods to enable recommendation of PDT as an alternative to conventional antifungal therapy.
Mass‐tag barcoding for multiplexed analysis of human synaptosomes and other anuclear events
Authors: Gajera Chandresh R. , Fernandez Rosemary , Montine Kathleen S. , Fox Edward J. , Mrdjen Dunja , Postupna Nadia O. , Keene Christopher Dirk , Bendall Sean C. , Montine Thomas J. 
Published: April 2021

AbstractMass‐tag cell barcoding has increased the throughput, multiplexing, and robustness of multiple cytometry approaches. Previously, we adapted mass cytometry for cells to analyze synaptosome preparations (mass synaptometry or SynTOF), extending mass cytometry to these smaller, anuclear particles. To improve throughput and individual event resolution, we report here the application of palladium‐based barcoding in human synaptosomes. Up to 20 individual samples, each with a unique combinatorial barcode, were pooled for labeling with an antibody cocktail. Our synaptosome protocol used six palladium‐based barcoding reagents, and in combination with sequential gating increased the identification of presynaptic events approximately fourfold. These same parameters also efficiently resolved two other anuclear particles: human red blood cells and platelets. The addition of palladium‐based mass‐tag barcoding to our approach improves mass cytometry of synaptic particles.
Gains or losses? A quantitative estimation of environmental and economic effects of an ecological compensation policy
Authors: Zhang Qian , Hong Jiayu , Wu Feng , Yang Yu , Dong Congcong 
Published: April 2021

AbstractEcological compensation is an innovative and effective tool to explore the coordinated development of socioeconomic prosperity and ecological protection, especially for a watershed crossing different regions. It converts the externalities of ecosystem services into practical financial incentives for local stakeholders. This empirical study applies a quantitative policy evaluation approach to evaluate the environmental and economic effects of an ecological compensation policy, using the paddy land–to–dry land (PLDL) program implemented in China’s Miyun Reservoir watershed as an example. The study is based on responses to a 2017 questionnaire regarding agricultural production inputs and outputs administered to 269 households in Hebei Province, where the PLDL program has been operational for over 10 yr. The results show that the program has reduced nitrogen usage by 24% on average in 2017 and decreased the total nitrogen emission load by 16.98 tons for the entire case area, which accounts for approximately 18.6% of the total nitrogen load reduction of the Miyun Reservoir basin. However, the upstream households involved in this program have experienced agricultural income losses higher than that allowed for by the current compensation criterion. Therefore, this paper discusses the factors that should be considered in the process of determining ecological compensation criteria. In particular, the paper proposes a differential compensation scheme based on the environmental effect at the individual level to avoid a standard payment for all households irrespective of their different contributions. This differential compensation payment scheme facilitates the fair treatment of environmental contributors and maximizes environmental benefits through an equitable allocation of limited ecological compensation funds. This study serves as a theoretical and practical reference for further improvement of the current ecological compensation policy in China. The study also sheds light on practices for estimating ecological compensation criteria and formulating ecological compensation policies for other regions or countries in the future.
Landscape epidemiology of Batrachochytrium salamandrivorans: reconciling data limitations and conservation urgency
Authors: Beukema Wouter , Erens Jesse , Schulz Vanessa , Stegen Gwij , Spitzen‐van der Sluijs Annemarieke , Stark Tariq , Laudelout Arnaud , Kinet Thierry , Kirschey Tom , Poulain Marie , Miaud Claude , Steinfartz Sebastian , Martel An , Pasmans Frank 
Published: April 2021

AbstractStarting in 2010, rapid fire salamander (Salamandra salamandra) population declines in northwestern Europe heralded the emergence of Batrachochytrium salamandrivorans (Bsal), a salamander‐pathogenic chytrid fungus. Bsal poses an imminent threat to global salamander diversity owing to its wide host range, high pathogenicity, and long‐term persistence in ecosystems. While there is a pressing need to develop further research and conservation actions, data limitations inherent to recent pathogen emergence obscure necessary insights into Bsal disease ecology. Here, we use a hierarchical modeling framework to describe Bsal landscape epidemiology of outbreak sites in light of these methodological challenges. Using model selection and machine learning, we find that Bsal presence is associated with humid and relatively cool, stable climates. Outbreaks are generally located in areas characterized by low landscape heterogeneity and low steepness of slope. We further find an association between Bsal presence and high trail density, suggesting that human‐mediated spread may increase risk for spillover between populations. We then use distribution modeling to show that favorable conditions occur in lowlands influenced by the North Sea, where increased survey effort is needed to determine how Bsal impacts local newt populations, but also in hill‐ and mountain ranges in northeastern France and the lower half of Germany. Finally, connectivity analyses suggest that these hill‐ and mountain ranges may act as stepping stones for further spread southward. Our results provide initial insight into regional environmental conditions underlying Bsal epizootics, present updated invasibility predictions for northwestern Europe, and lead us to discuss a wide variety of potential survey and research actions needed to advance future conservation and mitigation efforts.
Microhabitats associated with solar energy development alter demography of two desert annuals
Authors: Tanner Karen E. , Moore‐O’Leary Kara A. , Parker Ingrid M. , Pavlik Bruce M. , Haji Sophia , Hernandez Rebecca R. 
Published: April 2021

AbstractPolitical and economic initiatives intended to increase energy production while reducing carbon emissions are driving demand for solar energy. Consequently, desert regions are now targeted for development of large‐scale photovoltaic solar energy facilities. Where vegetation communities are left intact or restored within facilities, ground‐mounted infrastructure may have negative impacts on desert‐adapted plants because it creates novel rainfall runoff and shade conditions. We used experimental solar arrays in the Mojave Desert to test how these altered conditions affect population dynamics for a closely related pair of native annual plants: rareEriophyllum mohavenseand commonE. wallacei. We estimated aboveground demographic rates (seedling emergence, survivorship, and fecundity) over 7 yr and used seed bank survival rates from a concurrent study to build matrix models of population growth in three experimental microhabitats. In drier years, shade tended to reduce survival of the common species, but increase survival of the rare species. In a wet year, runoff from panels tended to increase seed output for both species. Population growth projections from microhabitat‐specific matrix models showed stronger effects of microhabitat under wetter conditions, and relatively little effect under dry conditions (lack of rainfall was an overwhelming constraint). Performance patterns across microhabitats in the wettest year differed between rare and common species. Projected growth ofE. mohavensewas substantially reduced in shade, mediated by negative effects on aboveground demographic rates. Hence, the rare species were more susceptible to negative effects of panel infrastructure in wet years that are critical to seed bank replenishment. Our results suggest that altered shade and water runoff regimes associated with energy infrastructure will have differential effects on demographic transitions across annual species and drive population‐level processes that determine local abundance, resilience, and persistence.
Network investigation of eating disorder symptoms and positive and negative affect in a clinical eating disorder sample
Authors: Wong Valerie Z. , Christian Caroline , Hunt Rowan A. , Levinson Cheri A. 
Published: April 2021

AbstractObjectiveGrowing literature suggests that emotions influence the maintenance of eating disorder (ED) symptoms. However, most research has studied the relationship between ED symptoms and affect broadly (i.e., negative affect [NA], positive affect [PA]), rather than examining models comprised of multiple specific affective states (e.g., upset, proud).MethodThe current study (N = 196 individuals with EDs) used network analysis to examine the most interconnected (i.e., central) NA and PA states in EDs and test the complex associations between specific NA, PA, and ED symptoms. We estimated two networks: one with affective states only and another with affective states and ED symptoms.ResultsFeeling distressed, afraid, attentive, and determined were the most central symptoms in the affect‐only network. ED symptoms related to overvaluation of weight and shape, including affect‐based ED symptoms (i.e., guilt about eating), were central in the network of affect and ED symptoms. Guilt about eating and shame were central bridge symptoms across affect and ED symptom clusters, meaning that they were each strongly connected across clusters, and may represent important pathways among affect and ED symptoms.DiscussionLimitations include the cross‐sectional and between‐person nature of these analyses, from which we cannot derive causal or within‐persons processes. Clinical interventions that target central and bridge symptoms (e.g., fear, shame) may disrupt the reinforcing cycle of NA in EDs that may contribute to ED behaviors. Future research should examine relationships among affective states and ED symptoms in longitudinal and intraindividual network models to develop more effective treatments for EDs.