bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting HIV-1 Envelope Proteins Using a Fragment Discovery All-Atom Computational Algorithm
Authors: Peters Michael H. 
Published: March 2021

Introduction:
HIV viral envelope proteins are targets for small inhibitor
molecules aimed at disrupting the cellular entry process. Potential peptide-class inhibitor
molecules (rDNA drugs) have been previously identified, with mixed results,
through biomimicry and phage display experimental methods. Here we describe a
new approach based on computational fragment discovery. The method has the potential
to not only optimize peptide binding affinity but also to rapidly produce alternative
inhibitors against mutated strains.

Methods:
A comprehensive, all-atom implicit solvent method is used to bombard
the C-heptad repeat unit of HIV-1 target envelope protein GP41 with single Damino
acid residues as they exist in their native state. A nascent peptide computational
search process then identifies potential favorable sequences of attached ligands based on four
peptide bond criteria. Finally, dynamic simulations of nascent peptides attached to host targets help refine
potential peptide inhibitors for experimental HIV-1 challenge assays and testing.

Results and Discussion:

Initial testing of the method was done using 64,000 total ligands of D-amino
acid residues at a total computational time of 0.05 microseconds per ligand, which resulted in several
thousand attached ligands. Peptide bond criteria search employing three of the four bond constraints
with a tolerance of 20 percent, resulted in four potential peptide inhibitors of 5 to 6 residues in length.
Only one of the four peptides demonstrated IC50 values and partial viral inhibition based on cell challenge
assays using CEM-SS host cells. That peptide inhibitor also computationally demonstrated longtime
attachment and stability to a helical groove in its C-heptad target. This initial testing of peptide
fragment discovery against HIV-1 has helped us refine the protocols and identify key areas of improvement.

Conclusion:
Our methods demonstrate the potential to design efficient peptide inhibitors to viral target
proteins based on an all-atom dynamic simulation and using a ligand library as fragments of potential
nascent peptides. Our methods can be greatly improved through the use of higher numbers of ligands,
increased time of bombardment, and tighter constraints on the peptide bond search step. Our method
may be important in the need to rapidly respond to target mutations and to advance multiple targeting
methods based multiple peptide inhibitors.
Therapeutically Important Natural Products and their Derivatives as a Target for Treatment of COVID-19 (SARSCoV2)
Authors: Subhash  , Chaudhary Ashu 
Published: March 2021

:
An epic coronavirus sickness spread into people and quickly gotten the epidemic liable aimed at the existing worldwide emergency. As of late, corona viral plague elevated the problem of creating viable against viral by the most punctual towards forestall additional misfortunes. Sadly, neither medication nor antibody up till now confirmed to forestall and cure the ailments brought about by Corona virus. In this way, viable counteraction and treatment drugs against human coronavirus are in critical need. The article depicts examination and possible manifestations just by way of the existing natural products treatment and furthermore centers around those natural intensifies that demonstrated promising outcomes against corona infections. natural products have consistently assumed a significant job in medicate advancement process against different ailments, which brought about showing these natural products towards the battle rising freaks to CoVs. Also, discoveries of past examinations for the modulation of the immune system and the medicine used for the treatment of viral infection exercises the specific nourishments also natural products proceeding flu infection and COVID-19 came to be ordered, through the point of advancing the utilization of nutritional treatment also natural medication as per corona virus protective treatments.
Editorial. El mar y la nave. Construcción de saberes y variaciones iconográficas-históricas en las alegorías del triunfo de la Iglesia católica
Authors: Gaune Rafael , Sanfuentes Olaya 
Published: March 2021

En este artículo introductorio al dossier “Emblemas, alegorías y otras imágenes del poder. Historias de éxito y fracaso”, quisiéramos proponer un acercamiento en torno a la lectura de imágenes a través de las claves hermenéuticas “éxito-fracaso” (Rocco-Lozano, 2020). Realizaremos un ejercicio descriptivo y metodológico de indagaciones libres de imágenes sobre los temas “nave” y “mar” en las alegorías del triunfo de la Iglesia católica en su expansión por el mundo, centrándonos, principalmente, en la alegoría atribuida al autor Miguel Jiménez, “El triunfo de la iglesia” (el vaso de la contemplación mística) del siglo xviii (Museo Nacional del Virreinato, Tepotzotlán). Esto nos ha guiado por diversos caminos investigativos y, sobre todo, se ha constituido como una cantera abierta de profundización que no pretende una aproximación teórica, sino más bien de posibilidades metodológicas alimentadas por los estudios de la imagen, la iconología y las trayectorias teóricas de la historia del arte y su profundidad de campo que nutren muchas de las disciplinas humanísticas. Al mismo tiempo, nombres relevantes como Aby Warburg, Erwin Panofsky, Ernst Gombrich, Michael Baxandall, Roberto Longhi, Carlo Ginzburg, Svetlana Alpers, Linda Nochlin, Susan Sontag, Ann Sutherland Harris y Jaynie Louise Anderson, entre otros (Burucúa, 2003), han marcado muchas de las reflexiones sobre las imágenes y el arte en los siglos xx y xxi y nos han ayudado a aproximarnos a los usos e interpretaciones de las imágenes.
Das matrizes documentais à memória no futuro
Authors: Araújo Denize Correa 
Published: March 2021

Este estudo é parte final de minha pesquisa sobre a trajetória dos diários confessionais e autorretratos desde o período do Renascimento até documentários autobiográficos e biopics atuais, e também reflete a pesquisa de meu pós-doutorado sobre éticas e estéticas em imagens das ditaduras. Esta parte do estudo desenvolve dois conceitos: o da imagem-memória e o da imagem-homenagem. O objetivo central é sugerir que documentários poderão ser, no futuro, a memória do passado. O corpus é formado pelo biopic David Lynch, A Vida de um Artista (2016) e pelo autobiográfico Dor e Gloria (2019). A metodologia é baseada no método histórico-dialético de Gadamer. O referencial teórico inclui conceitos de memória de Halbwachs, Sarlo, Le Goff, Ricoeur, Pollak e Nora, além do conceito de desconstrução de Derrida, dos estudos de Arlindo Machado, Nichols e Penafria sobre documentário e subjetividade, e de Bellour e Lebow sobre o eu ficcional/documental.
Pendapatan Usahatani Kelapa Sawit Petani Plasma dan Petani Swadaya di Kecamatan Luhak Nan Duo Kabupaten Pasaman Barat
Authors: Sari Karina Ratna , Hasnah Hasnah , Budiman Cipta 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui mendeskripsikan profil usaha perkebunan kelapa sawit petani plsama dengan petani swadaya dan menganalisis perbandingan pendapatan dan keuntungan usahatani kelapa sawit antara petani plasma dengan petani swadaya di Kecamatan Luhak Nan Duo Kabupaten Pasaman Barat. Metode penelitian yang digunakan adalah metode survey. Pengambilan data dilakukan melalui wawancara dan pengisian kuisioner. Metode survey adalah penyelidikan yang diadakan untuk memperoleh fakta-fakta dari gejala-gejala yang ada dan mencari keterangan-keterangan secara faktual,baik tentang insititusi soaial. Keuntungan merupakan selisih antara penerima dengan biaya yang dibayarkan dan biaya yang diperhitungkan dalam proses produksi. Rata-rata penerimaan yang diterima petani plasma perluas lahan adalah Rp. 6,412,800.00. Penerimaan petani swadaya adalah sebesar Rp. 13,000,985.22 per hektar.
Kata kunci: kelapa sawit, usahatani, keuntunngan, petani plasma
Nomophobia di Kalangan Mahasiswa (Studi Fenomenologi Pengguna Smartphone di Kalangan Anggota Wakesma, Fakultas Ilmu Sosial, Universitas Negeri Padang)
Authors: Karlina Mutiara , Gautama Mohammad Isa 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui makna penggunaan smartphone bagi anggota Wakesma FIS UNP yang dikategorikan sebagai penderita nomophobia. Teori yang digunakan dalam menganalisis penelitian ini ialah Teori Fenomenologi (Alfred Schutz) dan Media Equation Theory (Byron Reeves dan Clifford Nass). Penelitian ini menggunakan pendekatan penelitian kualitatif tipe fenomenologi dengan teknik pengumpulan informan adalah dengan purposive sampling. Dalam pengumpulan data dilakukan dengan cara observasi, wawancara mendalam yang dilakukan dengan menggunakan aplikasi whatsApp dan studi dokumentasi. Teknis analisis data dirujuk dari pemikiran Miles dan Huberman. Hasil dari penelitian ini menunjukan bahwa makna penggunaan smartphone bagi mahasiswa yaitu dijadikan sebagai alat berkomunikasi, gaya hidup, kebutuhan, dan media hiburan. Adapun tingkat kepentingan penggunaan smartphone bagi mahasiswa mecapai lebih dari 90% dengan rentang waktu penggunaan smartphone per jamnya mencapai 10 sampai 13 jam sehari. Penyebabnya dari ketergantungan mahasiswa terhadap smartphonenya berpusat dari fungsi smartphone itu sendiri, bagi mahasiswa smartphone merupakan suatu alat elektronik yang diciptakan untuk mempermudah segala sesuatu, baik untuk berkomunikasi, informasi, memesan makanan atau barang, belajar, bahkan sebagai dunia hiburan pelepas bosan dan menambah teman baru.
Penelitian ini bertujuan untuk mengetahui makna penggunaan smartphone bagi anggota Wakesma FIS UNP yang dikategorikan sebagai penderita nomophobia. Teori yang digunakan dalam menganalisis penelitian ini ialah Teori Fenomenologi (Alfred Schutz) dan Media Equation Theory (Byron Reeves dan Clifford Nass). Penelitian ini menggunakan pendekatan penelitian kualitatif tipe fenomenologi dengan teknik pengumpulan informan adalah dengan purposive sampling. Dalam pengumpulan data dilakukan dengan cara observasi, wawancara mendalam yang dilakukan dengan menggunakan aplikasi whatsApp dan studi dokumentasi. Teknis analisis data dirujuk dari pemikiran Miles dan Huberman. Hasil dari penelitian ini menunjukan bahwa makna penggunaan smartphone bagi mahasiswa yaitu dijadikan sebagai alat berkomunikasi, gaya hidup, kebutuhan, dan media hiburan. Adapun tingkat kepentingan penggunaan smartphone bagi mahasiswa mecapai lebih dari 90% dengan rentang waktu penggunaan smartphone per jamnya mencapai 10 sampai 13 jam sehari. Penyebabnya dari ketergantungan mahasiswa terhadap smartphonenya berpusat dari fungsi smartphone itu sendiri, bagi mahasiswa smartphone merupakan suatu alat elektronik yang diciptakan untuk mempermudah segala sesuatu, baik untuk berkomunikasi, informasi, memesan makanan atau barang, belajar, bahkan sebagai dunia hiburan pelepas bosan dan menambah teman baru.
Distress and Quality of Life among Type II Diabetic Patients: Role of physical activity
Authors: Kadari Devaraju , Padmaja Gadiraju , Rajak Binod 
Published: March 2021

This study measures the distress and Quality of Life (QoL) among people with type II diabetics in relation to physical exercise. The study was conducted using diabetic participants chosen from various hospitals, aerobic centres, playgrounds and gyms in the city of Hyderabad in India. The participants were divided into two groups – group 1 comprising people who did not adopt physical activity as part of their diabetes management strategy and group 2 comprising people who engaged in physical activity. A quasi-experimental study was performed on both groups employing purposive and snowball sampling methods. Pearson r showed that distress is negatively correlated with QoL among type II diabetics in both groups. Independent t-test indicated that participants in group 2 showed better QoL and lower levels of distress compared to their counterparts in group 1.
Impact of pairing an augmented reality demonstration with online video lectures… Does it improve students’ performance?
Authors: Kaliyaperumal Surendheran , Abd Wahab Mohd Helmy , Sagayam K. Martin , Ambar Radzi , Mhd Poad Hazwaj 
Published: March 2021

Due to the increased shifts in recent technologies, the education sector has also started to reshape itself to face the future. Augmented Reality (AR) and Virtual Reality (VR) are among the few recent trends that drive this shift forward. This study was set to study the impact of pairing a video lecture course with an AR presentation. A class of multimedia students (N=33) from Vellore Institute of Technology, Vellore, India; underwent an experiment of watching a video lecture module and attending a quiz. The same class again went through a similar test where they had to watch video lectures, get to experience what they learned in Augmented Reality for 10minutes, and then appeared for the quiz. The paired t-test conducted on the two sets of scores obtained by the class indicates a statistically significant increase in the average final scores when AR experience is paired with the video lectures. The feedback from the students was also positive on the AR experience.

Keywords: Augmented reality, Education, e-learning, Video lectures
Outbound Open Innovation Policy for Exploitation of Intellectual Creation, Design and Creativity in Malaysian Public Universities
Authors: Nor Mohamad Hashim Haswira , Muhamad Khair Muhamad Helmi , Mahmood Anida , Mohd Zakuan Zeti Zuryani 
Published: March 2021

The objective of the research is to explore the aim, application and strategy perceived as important in the development of an outbound open innovation policy for exploitation of intellectual creation, design and creativity in Malaysian public universities (MPUs). Under existing intellectual property, innovation and commercialization policies, a large portion of intellectual design, creation and creativity in MPUs remain unexploited. Hence, the need to develop a new set of aim, application and strategy to promote the exploitation of intellectual design, creation and creativity in MPUs. The research conducts a survey involving respondents representing the Technology Licensing Office of 15 MPUs. The research also analysed outbound open innovation policies from five universities in Australia, UK, US and South Africa. These policies provide the basis in the development of the survey instrument of the research. The survey instrument contains nine items outlining the aim, application and strategy for exploitation of an outbound open innovation policy. The survey findings indicate that eight of the items are perceived as important for the development of the policy. The findings of the survey provide a beneficial input for the development of an outbound open innovation policy for exploitation of intellectual design, creation and creativity in MPU.

Keywords: Creation, Creativity, Design, Innovation, Institutional Policy
Online Learning: A Post Covid-19 Alternative Pedagogy For University Students
Authors: Sim Sandra Phek-Lin , Sim Hannah Phek-Khiok , Quah Cheng-Sim 
Published: March 2021

The sudden COVID-19 pandemic situation experienced globally has caused many schools and institutions of higher learning to resort to fully online teaching and learning throughout the world, including Malaysia. As many educators and students braved the situation, and until a remedy is found to prevent the spread of this deadly coronavirus, the question that lingers in the mind of many people is ‘Will online learning be the way forward for university students in post COVID-19’? Most past research have reported on students’ experience of online mode of learning via a blended learning approach but there is relatively little research focusing on the real experience of students embarking on full online learning mode, especially in the state of Sarawak. Thus, this quantitative research aimed to identify the level of acceptance of online learning among university students who have experienced full online learning mode. It also intended to identify the factors that facilitated online learning and the challenges of online learning among university students. Data were collected using an online survey involving 156 respondents from a public university in the state of Sarawak. The data collected from the survey were analysed using descriptive statistics (means, frequency counts and percentages). Results showed a moderate high level of acceptance of online learning among the university students. In addition, results revealed that among the four main factors that facilitated online learning among the students, enhancement of English language skills ranked the highest, followed by enthusiasm, self-efficacy and satisfaction. This study also found that among the main challenges encountered by the majority of the students are issues of delivery speed of teaching and learning, students’ attitude, struggles and stress of online learning mode. Results yielded in this study add to the existing literature on the possibility of online learning as an alternative pedagogy in post COVID-19 for the education sector.

Keywords: Online Learning, Virtual Learning, Online Learning Pedagogy, Post COVID-19 Education, Challenges, University Students
Transformational Leadership with Moon Character: Empirical Evidence at STIEM Bongaya Campus
Authors: Akbar Abdi 
Published: March 2021

The leadership style at STIEM Bongaya is transformational leadership with a moon character not found on other campuses in Makassar City. We examine the role of involvement and the proactive role of transformational leadership relationships with employee performance. The reason for choosing the object is because the characteristics of ownership are family owned and are directed by second-generation family members, so it is interesting to study. This study used a sample of 83 employees to obtain accurate information in analyzing data by using WarpPLS 5.0. We find the transformational leadership of the moon character can improve employee performance. Because the leaders always emit the moonlight form of new enthusiasm, harmonization, comfort, and coolness, the employee engagement behavior becomes high. It has been rooted among employees that work orientation is noble. Involvement will be meaningful if there is an intelligent proactive role by the employee and the employee's performance becomes quality.
Procesy transformacji przemysłowych układów przestrzennych na tle zmieniającego się otoczenia
Authors: Zioło Zbigniew 
Published: March 2021

The paper presents a model of transformational processes in spatial forms of industry concentration. The model distinguishes various types of enterprises: leading, complementary, standard, and internal-demand firms, and types of surroundings: regional, national, and international. The paper presents passive and active relations occurring among all those categories
Przemysł stoczniowy w Polsce i na świecie
Authors: Dajczak Katarzyna 
Published: March 2021

The world economy is, to a larger and larger degree, connected with the sea and dependent on it, therefore there are no alternatives for ships and other naval objects – they are and will be built. It is definitely untrue that the shipbuilding industry decays. The trade is doing well and can do even better, at least with regards to the macroeconomic situation on the world market which enforces the necessity of scrapping a large part of the senescent freight fleet and imposes new requirements of greater safety of navigation or environmental protection. In such a situation, Polish shipyards are able to compete on the world’s shipping markets; they enjoy a good reputation among ship-owners. The ships built in Polish shipyards are characterized by high quality and are favoured in the world rankings of high prestige, thus the value of order book for ships systematically increases.
Inwestycje zagraniczne w przemyśle Krakowa
Authors: Huculak Maciej 
Published: March 2021

The paper consists of three main parts. The first part sketches out the role of Kraków in the foreign investments in the Małopolskie voivodship. In the second part, the Author presents the activity of foreign investors in Kraków industry in relation to the analogical processes in the whole voivodship. The last part contains a description of the greatest foreign investments in the industrial sector in Kraków. The article is partly based on the results of research in foreign capital enterprises in the Małopolskie voivodship, conducted in recent years by the Regional Development Section of the Institute of Geography and Spatial Management of the Jagiellonian University, with the participation of the Author.
Struktura przestrzenna i działowa przemysłu Polski na tle Unii Europejskiej w dwudziestolecie rozpoczęcia procesów transformacji systemowej
Authors: Rachwał Tomasz 
Published: March 2021

The aim of the paper is to analyze the changing role of industry in the Polish economy in the period of economic transformation and European integration based on its share of the employment structure and gross valued added, to determine changes in the spatial structure of Polish industry in the regions (voivodships) and changes in the divisions structure of Polish industry as an expression of restructuring processes. The paper also reviews changes in labour productivity in industry by voidodships, as an expression of modernity of industry and regional competitiveness in attracting industrial investment. The analysis of the similarity of divisions structures of industries in Poland in relation to other EU countries led to the conclusion that this structure increasingly becomes similar to most developed European countries.
Transformacja i globalna ekspansja brazylijskiego przemysłu lotniczego na przełomie XX i XXI wieku na przykładzie koncernu EMBRAER
Authors: Wójtowicz Mirosław 
Published: March 2021

The aim of the study is to analyse the process of historical growth, transformation and global expansion of the largest Brazilian aircraft industry enterprise – Embraer (Empresa Brasileira de Aeronautica). The company history can be divided into three main stages. The first one lasted from 1969 until the second half of the 1980s. In that stage, the company developed production supported mainly by the government or on license technology. The second stage lasted from the end of the 1980s to the mid-1990s. This was the stage of the crisis and transformation of the company, which ended up with its privatization and recovery. The last stage, lasting from 1996 to 2009, was characterized by dynamic growth of production and sales. The new family of regional jets (ERJ-145 and Embraer 170/190) turned out to be a great selling success which has enabled the company to maintain its position as a global leader in regional jets, which vies with the Canadian Bombardier for the third place in the world ranking of aircraft manufacturers.
Uwarunkowania rozmieszczenia usług turystycznych na Huculszczyźnie
Authors: Kibycz Anna 
Published: March 2021

In the article the level and conditions of development of tourist services in Hutsulshchyna is considered. The environmental and cultural potential of this mountain territory seems to be entirely unique in the 21st century. Historical, natural, and cultural conditions, and development of transport infrastructure are important in forming modern basic tourist infrastructure. As for today, tourist infrastructure and services are better developed in the Galicia district of Hutsulshchyna, where first-ever tourist cells were concentrated and a transport system is better developed. The Galicia district of Hutsulshchyna practically provides 70% of tourist services.