bluuebunny/crossref_metadata_2025_split huggingface dataset:
An enrichment strategy for clinical trials in SPMS
Authors: Koch Marcus W , Metz Luanne , Cutter Gary 
Published: January 2021

Background: We recently compared clinical outcomes in secondary progressive MS (SPMS) clinical trials and found an association of timed 25 foot walk (T25FW) worsening events and baseline disability scores. It is unclear whether disability worsening in clinical trials is comparable to that seen in clinical practice. Objective: The objective of this study is to compare disability worsening between the IMPACT and ASCEND data sets and data from the Calgary MS clinic and to characterize the association of baseline T25FW and expanded disability status scale (EDSS) scores with disability worsening. Methods: We combined the three data sets and investigated the impact of baseline characteristics on disability worsening with a logistic regression model. We calculated T25FW, EDSS, and ‘EDSS or T25FW’ worsening events as a function of ascending cut-off baseline disability scores. Results: Data source was not associated with T25FW worsening at 12 months. There was a strong association of baseline T25FW and EDSS cut-off scores with T25FW worsening. No such association was present for the EDSS and ‘EDSS or T25FW’. Conclusion: Our results suggest that it is possible to ‘enrich’ a trial cohort for expected T25FW worsening events using specific baseline T25FW and EDSS cut-off scores. These analyses inform the selection of inclusion criteria for clinical trials in SPMS.
Physical activity and screen time among youth with autism: A longitudinal analysis from 9 to 18 years
Authors: Dahlgren J , Healy S , MacDonald M , Geldhof J , Palmiere K , Haegele JA 
Published: January 2021

To date, studies using cross-sectional methodologies make up a majority of the literature surrounding children with autism spectrum disorders and participation in physical activity and screen time. Longitudinal studies are needed to examine how physical activity and screen time behaviors co-develop for children with and without an autism spectrum disorder. To address this research gap, this study compared how physical activity and screen time levels changed over time (9 to 18 years of age) between youth with autism spectrum disorder and youth with neurotypical development. Data on the levels of moderate-to-vigorous physical activity, light physical activity, television-, and video game-based screen time, collected as a part of the “Growing up in Ireland” study, were compared between youth with autism spectrum disorder and a propensity-matched sample of youth with neurotypical development ( n = 88 per group; 176 in total). Robust regression analyses indicated that children with autism spectrum disorder became less active over time compared to children with neurotypical development and that video game screen time also differed significantly between the groups when children were 9 years old. These findings elucidate important disparities present between these groups of children during pivotal developmental times. Lay abstract To date, studies using cross-sectional methodologies make up a majority of the literature surrounding children with autism spectrum disorders and participation in physical activity and screen time. Longitudinal studies are needed to examine how physical activity and screen time behaviors co-develop for children with and without an autism spectrum disorder. To address this research gap, this study compared how physical activity and screen time levels changed over time (from 9 to 18 years of age) between youth with autism spectrum disorder and youth with neurotypical development. Data on the levels of moderate-to-vigorous physical activity, light physical activity, television-, and video game-based screen time, collected as a part of the “Growing up in Ireland” study, were compared between youth with autism spectrum disorder and a propensity-matched sample of youth with neurotypical development ( n = 88 per group; 176 in total). Robust regression analyses indicated that children with autism spectrum disorder became less active over time compared to children with neurotypical development and that video game screen time also differed significantly between the groups when children were 9 years old. These findings elucidate important disparities present between these groups of children during pivotal developmental times.
Trends and outcomes of mechanically ventilated cirrhotic patients in the United States from 2005–2014
Authors: Cheung Kyle , Mailman Jonathan F , Crawford Jennifer J , Karvellas Constantine J , Sy Eric 
Published: January 2021

Purpose Cirrhotic patients in organ failure are frequently admitted to intensive care units (ICUs) to receive invasive mechanical ventilation (IMV). We evaluated the trends of hospitalizations, in-hospital mortality, hospital costs, and hospital length of stay (LOS) of IMV patients with cirrhosis. Methods We analyzed the United States National Inpatient Sample from 2005–2014. We selected discharges of IMV adult (≥18 years) patients with cirrhosis using the International Classification of Diseases, 9th Edition , Clinical Modification codes. Trends were assessed using linear regression and joinpoint regression. Results Between 2005 and 2014, there were approximately 9,441,605 hospitalizations of IMV adult patients, of which 4.7% had cirrhosis. There was an increasing trend in the total number of IMV cirrhotic patient hospitalizations (annual percent change [APC] 7.0%, 95% confidence interval [CI] 6.4%; 7.6%, Ptrend < 0.001). The in-hospital case-fatality ratio declined between 2005–2011 (APC –2.9%, 95% CI, –3.4%; –2.4%, Ptrend < 0.001); however, it remained similar between 2011–2014 ( Ptrend = 0.58). The total annual hospital costs of all IMV cirrhotic patients increased from approximately $1.2 billion USD in 2005 to $2.7 billion USD in 2014 ( Ptrend < 0.001). The mean hospital costs per patient and mean LOS declined between 2005 and 2014 ( Ptrend  < 0.001 and Ptrend = 0.01 respectively). Conclusions The total number of hospitalizations and total annual costs of IMV patients with cirrhosis have been increasing over time. However, past hesitancy around admitting cirrhotic patients to the ICU may need to be tempered by the improving mortality trends in this patient population.
A Development of the Essex-Lopresti Maneuver: Minimally Invasive Reduction and Fixation of Tongue-Type Calcaneal Fractures via a Single Incision
Authors: Budair Basil , Fenton Paul 
Published: January 2021

Tongue-type calcaneal fractures are a subset of displaced intraarticular calcaneal fractures. A reduction maneuver for this fracture pattern was described by Essex-Lopresti. The aim of this article is to describe a modification of this technique that allows reduction and fixation of tongue-type calcaneal fractures via a single, minimally invasive incision. We retrospectively reviewed all patients undergoing fixation utilizing this technique at our institution. We identified 13 fractures in 12 patients with a median follow-up of 12 months. Median Böhler angle was 3.5° preoperatively and 26.5° at final follow-up. The median AOFAS (American Orthopaedic Foot and Ankle Society) hindfoot score was 78. There were no complications or further surgeries in this series. We believe that reduction and fixation of tongue-type calcaneal fractures using this minimally invasive technique is safe and reliable and avoids the potential soft tissue problems of fixation with more extensive incisions. Levels of Clinical Evidence: Level IV
Anatomical Variations in the Origin of the Lingual Artery in the Kenyan Population
Authors: Sarna Krishan , Kamau Martin , Sonigra Khushboo Jayant , Amuti Thomas 
Published: January 2021

Study design: Descriptive cross-sectional study. Objective: To determine the variations in origin of the LA and its relationship to surgical landmarks. Background: The Lingual artery (LA) is a branch of the External Carotid Artery (ECA) that constitutes the principal supply to structures within the oral cavity and floor of the mouth. Knowledge of its variant anatomy is therefore vital during radiological and surgical procedures performed in the head and neck region since they may predispose it and other branches of the ECA to iatrogenic injury. There is, however, a dearth of regional data on the same. Materials and Methods: A total of 70 LA dissections were performed bilaterally on 35 human cadavers. The borders of the carotid triangle were identified after which the external carotid artery and its branches were exposed. The pattern of origin and the diameter of the LA was noted and distances from its origin to the CB, GCHB and the HN were measured. Similar measurements were carried out for any variant trunks. Data was collected and analyzed using SPSS (IBM version 27). A paired t-test was used to compare side differences. Representative photos of the vessel and its variations were taken. Results: The LA was found to be present in all cadavers dissected and was bilaterally symmetrical in 43% of cases. Four (4) types of branching patterns were encountered in the present study, the most commonly observed being the solitary LA followed by the LFT, TLT and finally the TLFT. The average diameter was least in the solitary pattern and greatest in the TLT. In relation to the CB, the solitary LA originated at a distance of 1.51 ± 0.89 cm while the LFT, TLT and TLFT originated at a distance of 1.80 ± 0.73 cm, 1.02 ± 0.64 cm and 1.25 ± 0.01 cm respectively from the CB. The mean distance from the origin of the LA to the GCHB was least in the TLT and greatest in the TLFT. With reference to the hypoglossal nerve, the LA was at an average, 0.82 ± 0.15 cm from the HN for the solitary pattern, 1.34 ± 0.86 cm for the LFT, 1.34 ± 0.90 cm for the TLT and 1.38 ± 0.93 cm for the TLFT. Conclusion: The LA in the Kenyan population exhibited a high frequency of variation in comparison to other populations regarding its pattern of origin and relationship to landmarks such as the CB, GCHB and HN. These findings may provide further insight into the understanding of the vascular anatomy to the radiologist and the surgeon to avert complications and improve overall treatment outcome.
A Systematic Review of Surgical Techniques for Management of Severe Rhinophyma
Authors: Benyo Sarah , Saadi Robert A. , Walen Scott , Lighthall Jessyka G. 
Published: January 2021

Study Design: Systematic review of the literature. Objective: The goal of this study is to review the current literature on severe rhinophyma requiring operative management for significant cosmetic deformity or nasal obstruction. We aim to provide a treatment algorithm for the various surgical techniques employed in the treatment of severe rhinophyma. Methods: Independent searches of the PubMed and MEDLINE databases were performed. Articles from the period of 2010 to 2020 were collected. All studies which described surgical treatment of severe rhinophyma using the Boolean method and relevant search term combinations, including “rhinophyma,” “severe,” “operative” and “surgery” were collected. Results: A total of 111 relevant unique articles met criteria for eligibility analysis. Of these, 85 articles were deemed inappropriate for the literature review due to exclusion criteria. The remaining 26 articles were included in the literature review. Due to variability in study design and outcome measures, formal synthesis of data in the form of a meta-analysis was not possible. Conclusions: Severe rhinophyma may present a reconstructive challenge to reestablish normal contour and patent nasal airway. Significant deformity necessitates surgical correction. The present article reviews the current literature and provides a summary and stepwise explanation of established surgical techniques for addressing the cosmetic and functional deficits these patients encounter.
Peptide Enhanced Bone Graft Substitute Presents Improved Short-Term Increase in Bone Volume and Construct Stiffness Compared to Iliac Crest Autologous Bone in an Ovine Lumbar Interbody Fusion Model
Authors: Loenen Arjan C. Y. , Connor Jerome , Johnson Scott , Davis Katherine , Hannigan Nolan , Barnes Tristan , Arts Jacobus J. , van Rietbergen Bert 
Published: January 2021

Study design: Preclinical ovine model. Objective: To assess the in vivo efficacy and safety of the P-15 L bone graft substitute and compare its performance to autologous iliac crest bone graft (ICBG) for lumbar interbody fusion indications. Methods: Thirty skeletally mature sheep underwent lumbar interbody fusion surgery. Half of the sheep received autologous ICBG and the other half the peptide enhanced bone graft substitute (P-15 L). Following termination at 1, 3, and 6 months after surgery, the operated segments were analyzed using micro computed tomography (µCT), histology, and destructive mechanical testing. Additional systemic health monitoring was performed for the P-15 L group. Results: One month after surgery, there was only minor evidence of bone remodeling and residual graft material could be clearly observed within the cage. There was active bone remodeling between 1 and 3 months after surgery. At 3 months after surgery significantly denser and stiffer bone was found in the P-15 L group, whereas at 6 months, P-15 L and ICBG gave similar fusion results. The P-15 L bone graft substitute did not have any adverse effects on systemic health. Conclusions: The drug device combination P-15 L was demonstrated to be effective and save for lumbar interbody fusion as evidenced by this ovine model. Compared to autologous ICBG, P-15 L seems to expedite bone formation and remodeling but in the longer-term fusion results were similar.
Lumbar Fusion Surgery for Patients With Back Pain and Degenerative Disc Disease: An Observational Study From the Canadian Spine Outcomes and Research Network
Authors: Evaniew Nathan , Swamy Ganesh , Jacobs W. Bradley , Bouchard Jacques , Cho Roger , Manson Neil A. , Rampersaud Y. Raja , Paquet Jerome , Bailey Christopher S. , Johnson Michael , Attabib Najmedden , Fisher Charles G. , McIntosh Greg , Thomas Kenneth C. 
Published: January 2021

Study Design: Uncontrolled retrospective observational study. Objectives: Surgery for patients with back pain and degenerative disc disease is controversial, and studies to date have yielded conflicting results. We evaluated the effects of lumbar fusion surgery for patients with this indication in the Canadian Spine Outcomes and Research Network (CSORN). Methods: We analyzed data that were prospectively collected from consecutive patients at 11 centers between 2015 and 2019. Our primary outcome was change in patient-reported back pain at 12 months of follow-up, and our secondary outcomes were satisfaction, disability, health-related quality of life, and rates of adverse events. Results: Among 84 patients, we observed a statistically significant improvement of back pain at 12 months that exceeded the threshold of Minimum Clinically Important Difference (MCID) (mean change -3.7 points, SD 2.6, p < 0.001, MCID = 1.2; 77% achieved MCID), and 81% reported being “somewhat” or “extremely” satisfied. We also observed improvements of Oswestry Disability Index (-17.3, SD 16.6), Short Form-12 Physical Component Summary (10.3, SD 9.6) and Short Form-12 Mental Component Summary (3.1, SD 8.3); all p < 0.001). The overall rate of adverse events was 19%. Conclusions: Among a highly selective group of patients undergoing lumbar fusion surgery for degenerative disc disease, most experienced a clinically significant improvement of back pain as well as significant improvements of disability and health-related quality of life, with high satisfaction at 1 year of follow-up. These findings suggest that surgery for this indication may provide some benefit, and that further research is warranted.
Back Dominant Pain Has Equal Outcomes to Radicular Dominant Pain Following Posterior Lumbar Fusion in Adult Isthmic Spondylolisthesis: A CSORN Study
Authors: Alnaghmoosh Nabeel , Urquhart Jennifer , Raj Ruheksh , Abraham Edward , Jacobs Bradley , Phan Philippe , Johnson Michael , Paquet Jerome , Nataraj Andrew , McIntosh Greg , Fisher Charles G. , Rampersaud Y. Raja , Manson Neil , Hall Hamilton , Rasoulinejad Parham , Bailey Christopher S. 
Published: January 2021

Study Design: Retrospective Cohort Study. Objectives: This study aimed to determine how the surgeon-determined and patient-rated location of predominant pain influences patient-rated outcomes at 1-year after posterior lumbar fusion in adult isthmic spondylolisthesis. Methods: We retrospectively reviewed consecutive patients prospectively enrolled in the Canadian Spine Outcomes and Research Network national registry between 2009 and 2017 that underwent posterior lumbar fusion for isthmic spondylolisthesis. Using longitudinal mixed-model repeated-measures analysis the change from baseline in patient-reported outcome measures (PROMs) at 1 year after surgery was compared between surgeon-determined groups (back vs. radicular) and between patient-rated pain groups (back, leg, and equal) derived from preoperative pain scores on the numerical rating scale (NRS). Results: 83/252 (33%) patients had a surgeon-determined chief complaint of back pain, while 103 (41%) patients rated their back pain as the predominant pain location, and 78 (31%) rated their back and leg pain to be equal. At baseline patients in the surgeon-determined radicular group had worse NRS-leg pain than those in the back-pain group but equal NRS-back pain. At baseline patients in the patient-rated equal pain group had similar back pain compared to the patient-rated back pain group and similar leg pain compared to the patient-rated leg pain group. All PROMs improved post-operatively and were not different between the 2 groups at 1 year. Conclusions: Our study found no difference in outcome, irrespective of whether a surgeon determines the patient’s primary pain complaint back or radicular dominant, or the patient rates pain in one location greater than another.
The Effectiveness of a Foundation Year 1 Doctor Preparation Course for Final Year Medical Students
Authors: Beedham William , Wanigasooriya Kasun , Layton Georgia R , Taing Chan Ley , Darr Adnan , Mittapalli Devender 
Published: January 2021

Background: Starting work as a junior doctor can be daunting for any medical student. There are numerous aspects of the hidden curriculum which many students fail to acquire during their training. Objectives: To evaluate the effectiveness of a novel foundation year one (FY1) doctor preparation course focusing on certain core topics, practical tips and components of the hidden curriculum. The primary objective was to improve the confidence level and knowledge of final year medical students transitioning to FY1 doctors. Method: A 2-day, practical course titled ‘Preparation 2 Practice’ delivering hands-on, small-group and lecture-based teaching, covering core medical student undergraduate curriculum topics in medicine and surgery. The course content spanned therapeutics, documentation skills and managing acute clinical tasks encountered by FY1 doctors during an on-call shift. A pre- and post-course survey and knowledge assessment were carried out to assess the effectiveness of the course. The assessment was MCQ-based, derived from topics covered within our course. The 20-question test and a short survey were administered electronically. Results: Twenty students from a single UK medical school attended the course. 100% participation was observed in the pre- and post-course test and survey. The median post-course test result was 22 (IQR 20.25-23.75) which was higher than the median pre-course test score of 18.75 (IQR 17-21.75). A Wilcoxon sign rank test revealed a statistically significant difference between the pre- and post-course test results ( P = .0003). The self-reported confidence score of delegates on starting work as a junior doctor was also significantly higher following the course ( P = .004). Conclusion: The results show a significant improvement in perceived confidence and knowledge on core curriculum topics amongst final year medical students having attended our FY1 doctor preparation course. We conclude that there is scope for similar supplementary courses as an adjunct to the undergraduate medical curriculum.
Crystalline Maculopathy Secondary to Retinal Tear Without Detachment
Authors: Tsimchi Imanouel M. , Dayani Pouya N. , Boyer David S. , Roe Richard H. 
Published: January 2021

Purpose: Crystalline maculopathy secondary to chronic retinal detachment (RD) has previously been described. This article proposes a novel mechanism to explain crystalline formation in the absence of RD. Methods: Two patients, who were referred for routine examination, were found to have a crystalline maculopathy in the setting of an asymptomatic, chronic-appearing, peripheral retinal tear. Fundoscopy and optical coherence tomography were used to assess the crystals and tear. No specimens were obtained. Results: We describe 2 cases of a crystalline maculopathy secondary to an asymptomatic peripheral retinal tear. We hypothesized macrophage ingestion of photoreceptor segments emanating from the tear may have contributed to macular crystalline deposition. Conclusions: Because crystalline maculopathy can present in the setting of RD, there may be a shared pathogenesis between the 2 conditions.
An attempt to unify the Brinell, Janka and Monnin hardness of wood on the basis of Meyer law
Authors: Koczan Grzegorz , Karwat Zbigniew , Kozakiewicz Paweł 
Published: January 2021

AbstractThis work concerns basic research on the concept of wood hardness in a sense similar to Brinell or in the modified sense of Monnin. The experimental part of this article is based on research carried out on beech wood with six indenters: three ball indenters of 10, 15 and 30 mm and three cylindrical indenters of 10, 15 and 30 mm. On the basis of measurements for a wide range of loads, relations analogous to Meyer power law of were obtained, with the exponent determined both for balls equal to 5/2 and for cylinders equal to 3/2. These exponents turned out to be exactly the arithmetic mean of exponents for ideally elastic and ideally plastic bodies. On this basis, new hardness formulae were proposed, taking into account Meyer law and the diameters of indenters. Therefore, the proposed two hardness formulae (for the ball and cylinder) are a generalization and development of Meyer hardness law.
Cobalt Phosphide (Co2P) with Notable Electrocatalytic Activity Designed for Sensitive and Selective Enzymeless Bioanalysis of Hydrogen Peroxide
Authors: Yin Donghang , Tang Junyan , Bai Rongbiao , Yin Shuyi , Jiang Mengnan , Kan Zigui , Li Hongmei , Wang Fei , Li Caolong 
Published: January 2021

AbstractIn this work, cobalt phosphide nanoparticles (Co2P NPs) were prepared by simple and mild hydrothermal method without the use of harmful phosphorous source. The morphological structure and surface component of Co2P were characterized by transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy measurements. Considering the excellent electrocatalytic reduction activity and good electrical conductivity of transition-metal phosphide, we fabricated Co2P NPs on indium tin oxide (ITO) substrate (Co2P/ITO) for H2O2 detection. The Co2P/ITO transducer displayed a rapid amperometric response less than 5 s, a broader response range from 0.001 to 10.0 mM and a low detection limit of 0.65 μM. In addition, the non-enzymatic Co2P/ITO sensor showed outstanding selectivity, reproducibility, repeatability and stability, all of which qualified the Co2P/ITO electrode for quite a reliable and promising biosensor for H2O2 sensing.