bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Drug Combinations for Chronic Pelvic Pain: Protocol for a Systematic Review
Authors: Mohiuddin Mohammed , Park Rex , Wesselmann Ursula , Pukall Caroline , Jarvi Keith , Nickel Curtis , Doiron Christopher , Gilron Ian 
Published: April 2021

Background
Chronic pelvic pain with various etiologies and mechanisms affects men and women and is a major challenge. Monotherapy is often unsuccessful for chronic pelvic pain, and combinations of different classes of medications are frequently prescribed, with the expectation of improved outcomes. Although a number of combination trials for chronic pelvic pain have been reported, we are not aware of any systematic reviews of the available evidence on combination drug therapy for chronic pelvic pain.

Objective
We have developed a protocol for a systematic review to evaluate available evidence of the efficacy and safety of drug combinations for chronic pelvic pain.

Methods
This systematic review will involve a detailed search of randomized controlled trials investigating drug combinations to treat chronic pelvic pain in adults. The databases searched will include the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and EMBASE from their inception until the date the searches are run to identify relevant studies. The primary outcome will be pain relief measured using validated scoring tools. Secondary outcomes, where reported, will include the following: adverse events, serious adverse events, sexual function, quality of life, and depression and anxiety. Methodological quality of each included study will be assessed using the Cochrane Risk of Bias Tool.

Results
The systematic review defined by this protocol is expected to synthesize available good quality evidence on combination drug therapy in chronic pelvic pain, which may help guide future research and treatment choices for patients and their health care providers.

Conclusions
This review will provide a clearer understanding of the efficacy and safety of combination pharmacological therapy for chronic pelvic pain.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42020192231; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=192231

International Registered Report Identifier (IRRID)
PRR1-10.2196/21909
Medical Students’ Perceptions of Play and Learning: Qualitative Study With Focus Groups and Thematic Analysis
Authors: Van Gaalen A E J , Jaarsma A D C , Georgiadis J R 
Published: April 2021

BackgroundIn times where distance learning is becoming the norm, game-based learning (GBL) is increasingly applied to health profession education. Yet, decisions for if, when, how, and for whom GBL should be designed cannot be made on a solid empirical basis. Though the act of play seems to be intertwined with GBL, it is generally ignored in the current scientific literature.ObjectiveThe objective of our study was to explore students’ perceptions of play in leisure time and of GBL as part of a mechanistic, bottom-up approach towards evidence-informed design and implementation of GBL in health profession education.MethodsWe conducted 6 focus group discussions with medical and dentistry students, which were analyzed using thematic analysis.ResultsA total of 58 students participated. We identified 4 major themes based on the students’ perception of play in leisure time and on the combination of play and learning. Our results indicate that, while play preferences were highly various in our health profession student cohort, pleasure was the common ground reported for playing. Crucially, play and the serious act of learning seemed paradoxical, indicating that the value and meaning of play are strongly context-dependent for students.ConclusionsFour key points can be constructed from our study. First, students play for pleasure. Perceptions of pleasure vary considerably among students. Second, students consider play as inefficient. Inefficiency will only be justified when it increases learning. Third, play should be balanced with the serious and only be used for difficult or tedious courses. Fourth, GBL activities should not be made compulsory for students. We provide practical implications and directions for future research.
Effects of Self-focused Augmented Reality on Health Perceptions During the COVID-19 Pandemic: A Web-Based Between-Subject Experiment
Authors: Seals Ayanna , Olaosebikan Monsurat , Otiono Jennifer , Shaer Orit , Nov Oded 
Published: April 2021

Background
Self-focused augmented reality (AR) technologies are growing in popularity and present an opportunity to address health communication and behavior change challenges.

Objective
We aimed to examine the impact of self-focused AR and vicarious reinforcement on psychological predictors of behavior change during the COVID-19 pandemic. In addition, our study included measures of fear and message minimization to assess potential adverse reactions to the design interventions.

Methods
A between-subjects web-based experiment was conducted to compare the health perceptions of participants in self-focused AR and vicarious reinforcement design conditions to those in a control condition. Participants were randomly assigned to the control group or to an intervention condition (ie, self-focused AR, reinforcement, self-focus AR × reinforcement, and avatar).

Results
A total of 335 participants were included in the analysis. We found that participants who experienced self-focused AR and vicarious reinforcement scored higher in perceived threat severity (P=.03) and susceptibility (P=.01) when compared to the control. A significant indirect effect of self-focused AR and vicarious reinforcement on intention was found with perceived threat severity as a mediator (b=.06, 95% CI 0.02-0.12, SE .02). Self-focused AR and vicarious reinforcement did not result in higher levels of fear (P=.32) or message minimization (P=.42) when compared to the control.

Conclusions
Augmenting one’s reflection with vicarious reinforcement may be an effective strategy for health communication designers. While our study’s results did not show adverse effects in regard to fear and message minimization, utilization of self-focused AR as a health communication strategy should be done with care due to the possible adverse effects of heightened levels of fear.
Teleconsultation in the Management of Elective Orthopedic and Spinal Conditions During the COVID-19 Pandemic: Prospective Cohort Study of Patient Experiences
Authors: Melian Christina , Frampton Christopher , Wyatt Michael Charles , Kieser David 
Published: April 2021

Background
The global adoption of teleconsultation has been expedited as a result of the COVID-19 pandemic. By allowing remote communication, teleconsultation may help limit the spread of the virus while maintaining the crucial patient-provider relationship.

Objective
The aim of this study is to evaluate the value of teleconsultation compared to in-person visits in the management of elective orthopedic and spinal procedures.

Methods
This was a prospective observational cohort study of 853 patients receiving orthopedic and spinal care at a private outpatient clinic in New Zealand. Patients were randomly divided into two groups: (1) patients receiving telephone consultation remotely, and (2) patients receiving in-person office consultations at the outpatient clinic. All patients received telephone consultations for 4 weeks during the mandated COVID-19 lockdown, followed by 4 weeks of telephone or in-person consultation. Patient preference, satisfaction, and duration of visit were recorded. Comparisons of patient preference between groups, visit type, sex, and location were performed using chi-square tests; similarly, satisfaction scores and visit durations were compared using a general linear model.

Results
We report that 91% (353/388) of patients in the telephone group preferred teleconsultation over in-person office visits during the COVID-19 lockdown (P<.001). A combined-group analysis showed that 55.3% (446/807) of all patients preferred teleconsultation compared to 31.2% (252/807) who preferred in-person office visits (P<.001). Patients in the telephone group reported significantly higher satisfaction scores (mean 9.95, SD 0.04, 95% CI 9.87-10.03) compared to patients in the in-person group (mean 9.53, SE 0.04, 95% CI 9.45-9.62; P<.001). Additionally, in-person consultations were significantly longer in duration compared to telephone consultations, with a mean visit time of 6.70 (SE 0.18) minutes, 95% CI 6.32-7.02, compared to 5.10 (SE 0.17) minutes, 95% CI 4.73-5.42 (P<.001).

Conclusions
Patients who use telephone consultations are more likely to prefer it over traditional, in-person visits in the future. This increased preference, coupled with higher patient satisfaction scores and shorter duration of visits, suggests that teleconsultation has a role in orthopedic surgery, which may even extend beyond the COVID-19 pandemic.
Pengaruh Kepemimpinan Visioner Kepala Madrasah terhadap Kedisiplinan Guru di MAN 2 Samarinda
Authors: Marantika Marantika , Dahlan Dwi Nur Aini 
Published: April 2021

Visionary leadership is a capability to make changes by having new visions and ideas, thinking ahead, carrying out stages of mutual interconnection that can influence and motivate teachers and their students. This research aims to find out the effect of leadership of Madrasah Principal Visionary to Teacher Discipline. The type of this research is quantitative research. The population in this study were all 60 teachers in MAN 2 Samarinda. The data of this research is obtained from questionnaire, observation and documentation. The data analysis technique uses product moment correlation formula, determinant coefficient (R²) and t test. The results of this study shows the results of the t-test value of 3.5090> t table 2.00172, which means that Ho is rejected and Ha is accepted. The meaning is there is a correlation between variable X and Y, product correlation 0.416. That means there is a strong correlation between visionary leadership variable and teacher discipline variable. Percentage of visionary leadership for teacher discipline is 17.30% (strong enough), the factors that cause these results include: giving the best performance without analyzing / following new era, inability to change teachers knowledge into strategy, and treating teachers differently causing conflicting duties. The supporting and inhibiting factors in managing teacher discipline include: teacher personalitty, the headmaster teachers supervision.
Pertumbuhan, hasil, dan fenologi ratun hanjeli varietas Batu pada kondisi kekeringan
Authors: Putri Yuliar Syelvia , Nurmala Tati , Irwan Aep Wawan 
Published: April 2021

Abstrak. Tanaman hanjeli (Coix lacryma-jobi) merupakan salah satu tanaman pangan lokal fungsional yang berpotensi sebagai bahan pangan, pengobatan medis, dan kerajinan. Permasalahan pada komoditas hanjeli adalah umur panen yang lama dan produktivitas rendah saat penanaman hanjeli ratun di musim kemarau. Perlakuan ratun diharapkan mampu mempersingkat pertumbuhan vegetatif hanjeli sehingga didapatkan umur panen yang genjah dan memberikan informasi mengenai frekuensi penyiraman yang tepat untuk meningkatkan produktivitas. Penelitian ini bertujuan untuk mengkaji pertumbuhan, hasil, dan fenologi hanjeli ratun var. stenocarpa. Penelitian ini dilakukan di Kebun Percobaan Ciparanje, Fakultas Pertanian, Universitas Padjadjaran, dari Februari hingga September 2019. Penelitian ini menggunakan metode deskriptif augmented. Tanaman hanjeli ditanam di kadar air tanah 60% (frekuensi penyiraman setiap hari) dan kadar air tanah 30% (frekuensi penyiraman empat hari sekali). Hasil penelitian menunjukkan bahwa terdapat perbedaan pada komponen pertumbuhan, hasil, dan fenologi tanaman hanjeli ratun terhadap frekuensi penyiraman berbeda. Waktu panen pada tanaman ratun lebih cepat dibandingkan tanaman utama.Kata Kunci: Fenologi, Frekuensi penyiraman, Hanjeli batu, Ratun. Abstract. Job’s tears (Coix lacryma-jobi L.) is local functional food that can be used for food, medical treatment and crafts. The problems are long harvest period and low productivity when cultivate Job Tear’s raton in dry season. The treatment of ratoon is expected to be able to suppress vegetative growth of the job's tears and give information about appropriate of watering frequency to increase productivity. This research aims to study phenologycal, growth, and yield of job’s tears ratoon. The study was conducted in February 2019–September 2019 at Ciparanje Experimental Station, Faculty of Agriculture, Padjadjaran University, Jatinangor. This research was used descriptive method. Job’s Tears plants were cultivated in 60% of soil water content (daily watering frequency) and 30% soil water content (watering frequency every four days). The result showed there are differences of growth, yield, and phenologycal of the Job Tear’s plant to different watering frequency. Time of harvest Job Tear’s plant ratoon is faster than the main crop.Keywords: Job’s tears var Stenocarpa, Phenology, Ratoon, Watering frequency.
Pengaruh macam media tanam dan konsentrasi zat pengatur tumbuh terhadap pertumbuhan stek dua nodus melati
Authors: Safitri Rina , Rahayu Tri , Widiastuti Libria 
Published: April 2021

Abstrak. Hormon auksin, giberelin, sitokinin, dan asam traumalin, serta media tanam yang tepat diketahui dapat meningkatkan pertumbuhan tunas dan akar pada stek. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi zat pengatur tumbuh dan macam media tanam terhadap pertumbuhan stek melati (Jasminum sambac L.) dengan dua nodus. Percobaan menggunakan Rancangan Acak Lengkap (RAL) pola faktorial. Perlakuan terdiri dari dua faktor dan tiga kali ulangan. Faktor yang pertama yaitu konsentrasi dari campuran zat pengatur tumbuh, terdiri dari taraf 0; 0,15; dan 0,30 mL/L. Faktor kedua yaitu campuran media tanam dengan perbandingan sama, terdiri dari taraf tanah dan pupuk kandang; tanah dan cocopeat; serta tanah, pupuk kandang, dan cocopeat. Analisis data menggunakan uji Jarak Berganda Duncan pada taraf nyata 5%. Hasil percobaan menunjukkan bahwa tidak terdapat pengaruh interaksi antara konsentrasi zat pengatur tumbuh dengan macam media tanam terhadap pertumbuhan stek dua nodus melati. Pengaruh konsentrasi zat pengatur tumbuh 0,30 mL/L secara mandiri memberikan pertumbuhan paling baik pada kecepatan tumbuh dan tinggi tunas stek. Pengaruh media tanam tanah dan pupuk kandang secara mandiri memberikan pertumbuhan paling baik pada kecepatan tumbuh dan tinggi tunas.Kata Kunci: Dua nodus, Media tanam, Melati, Stek, Zat pengatur tumbuh. Abstract. The plant hormones such as auxin, gibberellin, cytokinins, and traumalic acid, as well as appropriate growing media, are known to increase shoot and root growth on cuttings. This study aims to determine the effect of the concentration of plant growth regulators and the growing media on the growth of two nodes jasmine (Jasminum sambac L.) cuttings. The experiment used a factorial completely randomized design. The treatment consisted of two factors and three replications. The first factor was the concentration of a mixture of plant growth regulators, consisted of levels: 0; 0.15; and 0.30 mL/L. The second factor was mixture of growing media with the same ratio, consisted of levels: soil and manure; soil and cocopeat; and soil, manure, and cocopeat. Data analysis used the Duncan Multiple Range test at the 5% significant level. The results showed that there was no interaction effect between the concentration of growth regulators and the growing media on the growth of two nodes of jasmine cuttings. The single effect of concentration of plant growth regulator 0.30 mL/L gave the best growth at the growth rate and shoot height. The single effect of soil and manure gave the best growth at growth rate and shoot height.Keywords: Two Nodes, Growth regulators, Growing media, Cuttings, Jasmine
En torno a Nietzsche y la «cuestión homérica»
Authors: Pòrtulas Jaume 
Published: April 2021

Tras una breve introducción acerca de las relaciones, con frecuencia difíciles y conflictivas, que Friedrich Nietzsche mantuvo con su profesión de filólogo clásico y con muchos de sus representantes, el presente trabajo se centra en la tres contribuciones sin duda más significativas del filólogo y pensador a los estudios homéricos: 1) la lección inaugural de la cátedra de Basilea, Homero y la filología clásica (1869); 2) el estudio sobre el manuscrito florentino del «Certamen de Homero y Hesíodo», publicado en dos entregas (1870 y 1873) en el Rheinisches Museum für Philologie, y 3) el brillante apunte de 1872 acerca de «El agôn en Homero». Se dedica un extenso análisis a la parte central del primero de estos textos, con el propósito de comprender mejor ciertos pasajes largamente discutidos. También se destacan algunos elementos de continuidad entre los trabajos juveniles y el despliegue posterior del pensamiento de Nietzsche.
Study on water damage mechanism of asphalt pavement based on industrial CT technology
Authors: Chuan-Xi Luo , Jun He , Wei-Xiong Li , Zhi-Yong Huang , Qi-Bin Sun , James Mijash 
Published: April 2021

Abstract
It is impossible to study the relationship between water damage and voidage of asphalt pavement because the voidage of pavement core sample cannot be determined accurately. Based on the industrial computed tomography (CT) scanning technology for core samples of real void fraction measurement, dynamic water flushing apparatus to water damage damage of core samples, the CT scan void fraction and destruction after the relationship between splitting strength and CPN rutting depth of core samples, respectively, set up different lanes of void fraction and cleavage strength and the fitting formula of rut depth.
Reducibility in Corsini hypergroups
Authors: Kankaras Milica 
Published: April 2021

Abstract
In this paper, we study the reducibility property of special hyper-groups, called Corsini hypergroups, named after the mathematician who introduced them. The concept of reducibility was introduced by Jantosciak, who noticed that it can happen that hyperproduct does not distinguish between a pair of elements. He defined a certain equivalences in order to identify elements which play the same role with respect to the hyperoperation. First we will determine specific conditions under which the Corsini hypergroups are reduced. Next, we will present some properties of these hypergroups necessary for studying the fuzzy reducibility property. The fuzzy reducibility will be considered with respect to the grade fuzzy set μ̃, used for defining the fuzzy grade of a hypergroup. Finally, we will study the reducibility and the fuzzy reducibility of the direct product of Corsini hypergroups.
Coincidence and Common Fixed Point Theorems via ϱ-Class Functions in Elliptic Valued Metric Spaces
Authors: Öztürk Mahpeyker , Kösal Işıl A. , Kösal Hidayet H. 
Published: April 2021

Abstract
The main goal of this study is to define a new metric space which is a generalization of complex valued metric spaces introduced by Azam et al. [1] using the set of elliptic numbers

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{\mathbb{E}_p} = \left\{ { \in = \upsilon + i\omega :\upsilon ,\omega \in \mathbb{R},\,\,{i^2} = p < 0} \right\},

and this space is named as an elliptic valued metric space. Some topological properties of this new space are examined. Also, some fixed point results are established in the setting of elliptic valued metric spaces by introducing new classes of mappings which the obtained results are real generalizations of the consequences of several fixed point theorems in the existing literature.
Bibliometric-based Study of Scientist Academic Genealogy
Authors: Lv Ruihua , Chang Huan 
Published: April 2021

Abstract

Purpose
This study aims to construct new models and methods of academic genealogy research based on bibliometrics.

Design/methodology/approach
This study proposes an academic influence scale for academic genealogy, and introduces the w index for bibliometric scaling of the academic genealogy. We then construct a two-dimensional (academic fecundity versus academic influence) evaluation system of academic genealogy, and validate it on the academic genealogy of a famous Chinese geologist.

Findings
The two-dimensional evaluation system can characterize the development and evolution of the academic genealogy, compare the academic influences of different genealogies, and evaluate individuals’ contributions to the inheritance and evolution of the academic genealogy. Individual academic influence is mainly indicated by the w index (the improved h index), which overcomes the situation of repeated measurements and distortion of results in the academic genealogy.

Practical implications
The two-dimensional evaluation system for the academic genealogy can better demonstrate the reproduction and the academic inheritance ability of a genealogy.

Research limitations
It is not comprehensive to only use the w index to characterize academic influence. It should also include scholars’ academic awards and academic part-timers and so on. In future work, we will integrate scholars’ academic awards and academic part-timers into the w index for a comprehensive reflection of scholars’ individual academic influences.

Originality/value
This study constructs new models and methods of academic genealogy research based on bibliometrics, which improves the quantitative assessment of academic genealogy and enriches its research and evaluation methods.
Yao syndrome: A potential role and association of vasoactive intestinal peptide with NOD2
Authors: Navetta-Modrov Brianne , Ghebrehiwet Berhane , Yao Qingping 
Published: April 2021

Abstract
Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is a cytosolic receptor. Both NOD2 and vasoactive intestinal peptide (VIP) are critical in regulation of immune and inflammatory response. Yao syndrome (YAOS, OMIM 617321) is an autoinflammatory disease associated with specified NOD2 mutations. Herein, we report a well-studied case of YAOS masquerading as mast cell disorder and neuroendocrine tumors to support the involvement of VIP in YAOS. For the first time, this case study suggests a potential relationship between NOD2 and VIP. This could provide a novel avenue for mechanistic study of NOD2-associated disease.
The role of imaging in predicting the development of rheumatoid arthritis
Authors: So Ho , Cheng Isaac , Tam Lai-Shan 
Published: April 2021

Abstract
Rheumatoid arthritis (RA) remains a chronic debilitating disease with a significant negative societal impact, despite the expanding landscape of treatment options. This condition is often preceded by a phase of systemic autoimmunity with circulating autoantibodies, elevated pro-inflammatory cytokines, or subtle structural changes. The capability of identifying individuals in the preclinical phase of RA disease makes a “preventive window of opportunity” possible. Much recent work has focused on the role of imaging modalities including ultrasound (US), magnetic resonance imaging (MRI), and high-resolution peripheral quantitative computer tomography (HR-pQCT) in identifying at-risk individuals with or without early joint symptoms for the development of inflammatory arthritis. This article will review the evidence and discuss the challenges as well as opportunities of proactive risk assessment by imaging in RA.