bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of philosophy and ethics at the edges of medicine
Authors: Hofmann Bjørn 
Published: November 2021

AbstractBackgroundThe edge metaphor is ubiquitous in describing the present situation in the world, and nowhere is this as clearly visible as in medicine. “The edge of medicine” has become the title of books, scholarly articles, media headlines, and lecture series and seems to be imbued with hype, hope, and aversion. In order better to understand what is at stake at “the edge of medicine” this article addresses three questions: What does “the edge of medicine” mean in contemporary debates on modern medicine? What are the challenges “on the edge of medicine” (in these various meanings of “on the edge”)? How can philosophy and ethics contribute with addressing these challenges?MethodsLiterature searches in PubMed and Google Scholar are used to identify uses of the phrase “the edge of medicine” while conventional content analysis is used to analyze meanings of and challenges with “the edge of medicine.” These results are then investigated with respect to how philosophy and ethics can address the identified challenges.ResultsThe literature reveals that “the edge of medicine” has many meanings, such as: Border; Margin (of life); Frontier; Forefront; Fringes; Plunge (abyss); Brink (verge); Conflict; and Balancing. In general, the various meanings address four basic challenges: setting limits, keeping control, make meaning, and handling conflicts or aporias. The analysis of each of the meanings of “the edge of medicine” identifies a wide range of important and urgent tasks for the humanities in general, and for philosophy and ethics in particular: 1) clarifying concepts; 2) clarifying assumptions and premises of arguments, methods, advice, and decisions; 3) elaborate new concepts and new theories; 4) conceptualize and handle uncertainty, moral regret, and residue; 5) reveal “the emperor’s new clothes;” 6) identify trends and reflect on their implications; 7) demarcation; and 8) reflecting on goodness in medicine.ConclusionThe phrase “the edge of medicine” expresses a wide range of challenges for modern health care. Together with other disciplines philosophy and ethics can and should make crucial contributions at “the edge of medicine,” which is where the future of human beings and societies is created and formed.
Association of the type of counselor with suicidal ideation and suicide attempts: a survey of South Korean adolescents
Authors: Kim Yunkyung , Jeong Wonjeong , Yang Jieun , Lee Sang Ah , Park Eun-Cheol 
Published: November 2021

AbstractBackgroundCounseling for adolescents who consider or attempt suicide may help reduce suicide rates. However, the impact of the type of counselor (e.g., father, mother, sibling, friend, teacher, other) on suicidal ideation/suicide attempts remains unclear. Therefore, we examined this association in Korean adolescents.MethodsUsing data from the 2015 Korea Youth Risk Behavior Web-based Survey of 65,485 adolescents, we examined risk factors for suicidal ideation/suicide attempts according to sex using a multiple logistic regression analysis. In a subgroup analysis, we investigated the associations between counselor type and suicidal ideation/suicide attempts stratified by the cause of stress for both sexes.ResultsMale participants were less likely to consider suicide when counseled by their mother (odds ratio [OR] 0.80; 95% confidence interval [CI] 0.70–0.90) or friend (OR 0.89; 95% CI 0.80–0.99) and to attempt suicide when counseled by a friend (OR 0.74; 95% CI 0.60–0.92) than were those who did not receive any counseling. Female participants were less likely to attempt suicide when counseled by their mother (OR 0.66; 95% CI 0.53–0.82) or friends (OR 0.70; 95% CI 0.58–0.83) than when not counseled. Furthermore, adolescents with achievement/career choice-related and family problems were at a lower risk of suicide ideation/suicide attempts when counseled by their mother or friend than when they received no counseling.ConclusionsSuicidal ideation/suicide attempts showed different associations for both sexes in accordance with the type of counselor. Even if counseling by specialists for issues such as achievement/career choice-related or family matters is needed, the risk of suicide could be reduced through counseling by the people around them. Therefore, adolescents should form mutually supportive relationships through active communication with surrounding people.
Competitive sport after SARS-CoV-2 infection in children
Authors: Cafiero Giulia , Passi Flaminia , Calo’ Carducci Francesca Ippolita , Gentili Federica , Giordano Ugo , Perri Chiara , Hashem Said Melania , Turchetta Attililo 
Published: November 2021

Abstract
Background
With the gradual resumption of sports activities after the lock-down period for coronavirus pandemic, a new problem is emerging: Allow all athletes to be able to return to compete after SARS-CoV-2 infection in total safety. Several protocols have been proposed for healed athletes but all of them have been formulated for the adult population. The aim of the present study is to evaluate the adequacy of Italian practical recommendations for return-to-paly, in order to exclude cardiorespiratory complications due to COVID-19 in children and adolescents.

Methods
Between April 2020 and January 2021 the Italian Sports Medical Federation formulated cardiorespiratory protocols to be applied to athletes recovered from SARS-CoV-2 infection. The protocols take into account the severity of the infection. Protocols include lung function tests, cardiopulmonary exercise test, echocardiographic evaluation, blood chemistry tests.

Results
From September 2020 to February 2021, 45 children and adolescents (aged from 9 to 18 years; male = 26) with previous SARS-CoV-2 infection were evaluated according to the protocols in force for adult. 55.5% of the subjects (N = 25) reported an asymptomatic infection; 44.5% reported a mild symptomatic infection. Results of lung function test have exceeded the limit of 80% of the theoretical value in all patients. The cardiorespiratory capacity of all patients was within normal limits (average value of maximal oxigen uptake 41 ml/kg/min). No arrhythmic events or reduction in the ejection fraction were highlighted.

Conclusion
The data obtained showed that, in the pediatric population, mild coronavirus infection does not cause cardiorespiratory complications in the short and medium term. Return to play after Coronavirus infection seems to be safe but it will be necessary to continue with the data analysis in order to modulate and optimize the protocols especially in the pediatric field.
An appraisal on enablers for enhancement of waste cooking oil-based biodiesel production facilities using the interpretative structural modeling approach
Authors: Kukana Rajendra , Jakhar O. P. 
Published: November 2021

AbstractWith the continuous depletion of energy sources globally and serious concern regarding environmental degradation by the use of fossil fuel, biodiesel may play a key transponder. Biodiesel blended with diesel fuel achieves a decreased environmental footprint without losing the reliability of output and consumption. Biodiesel is produced from a variety of sources. Biodiesel generation from waste cooking oil (WCO) is effective for both the atmosphere and human health. Many research studies reported WCO biodiesel as a potential alternative fuel for internal combustion engine. The present study aims to provide key promoting and implementing agents for WCO utilization and WCO-based biodiesel production. A systematic literature review has been performed to identify enablers and the contextual relationship between various enablers was developed using interpretative structural modeling (ISM) and expert views. Using the method of ISM and cross-impact matrix multiplication applied to classification (MICMAC) methodology, the impact of enablers is studied. The findings revealed that all established enablers play an important role and are equally important promoters for the development of biodiesel based on WCO. The findings further suggest that human health issues, biodiesel processing plants, biodiesel support vehicles, and biodiesel production technology play a key role in the manufacture of biodiesel dependent on WCO. The most important leaders in the development of WCO biodiesel are government policy and funding, confidence in environmental issues, and financial assistance to biodiesel manufacturers.
A note on the approximate controllability of second-order integro-differential evolution control systems via resolvent operators
Authors: Vijayakumar Velusamy , Shukla Anurag , Nisar Kottakkaran Sooppy , Jamshed Wasim , Rezapour Shahram 
Published: November 2021

AbstractThe approximate controllability of second-order integro-differential evolution control systems using resolvent operators is the focus of this work. We analyze approximate controllability outcomes by referring to fractional theories, resolvent operators, semigroup theory, Gronwall’s inequality, and Lipschitz condition. The article avoids the use of well-known fixed point theorem approaches. We have also included one example of theoretical consequences that has been validated.
Some variants of Wardowski fixed point theorem
Authors: Nazam Muhammad , Aydi Hassen , Park Choonkil , Arshad Muhammad , Savas Ekrem , Shin Dong Yun 
Published: November 2021

AbstractThe purpose of this paper is to consider some F-contraction mappings in a dualistic partial metric space and to provide sufficient related conditions for the existence of a fixed point. The obtained results are extensions of several ones existing in the literature. Moreover, we present examples and an application to support our results.
Nitrogen use efficiency of terrestrial plants in China: geographic patterns, evolution, and determinants
Authors: Liao Jiaqiang , Li Zhaolei , Wang Jinsong , Tian Dashuan , Tian Di , Niu Shuli 
Published: November 2021

Abstract
Background
Plant nitrogen use efficiency (NUE) is an important ecological indicator that reflects the capacity of a plant to transform nitrogen into production, which is essential for further elucidating plant growth and terrestrial ecosystem productivity. Although there are a growing number of studies that address NUE changes at local scales, the variations of NUE over large spatial scales remain unclear. In this study, we analyzed the geographic patterns of NUE and explored its phylogenic and environmental drivers across 1452 species at 1102 sites in China.

Results
NUE tended to decrease with latitude (r = − 0.56), whereas it increased with longitude (r = 0.54), and varied widely in different ecosystems and plant life forms. Furthermore, NUE was negatively correlated with plant foliar phosphorus concentration (r = − 0.53), soil pH (r = − 0.10), soil total phosphorus (r = − 0.13) and available phosphorus (r = − 0.05), but positively with the mean annual temperature (r = 0.32), annual precipitation (r = 0.27), and aridity index (r = 0.26). NUE was significantly altered with phylogeny and evolved toward a lower value (r = − 0.28), which may have been due to increasing nitrogen deposition and fixation in biogeochemical evolution. Overall, the combination of foliar phosphorus concentration, phylogeny, climate, and soil properties accounted for 52.7% of the total variations of NUE. In particular, foliar phosphorus concentration was the most important factor, whereas plant evolutionary history was second in contributing to NUE variations.

Conclusions
Our study emphasizes the pivotal role of plant stoichiometry and phylogeny in nitrogen cycling and suggests incorporating them into earth system models to better understanding plant growth and nitrogen cycling in the context of environmental changes.
Staphylococcus aureus - selective reporting of antibiogram results and its impact on antibiotic use: Interventional study with a reference group on the effect of switching from non-selective to selective antibiotic reporting
Authors: Lestin-Bernstein Franka , Harberg Ramona , Schumacher Ingo , Briedigkeit Lutz , Heese Oliver , Biedermann Kristina 
Published: November 2021

Abstract
Background
Antimicrobial stewardship (AMS) strategies worldwide focus on optimising the use of antibiotics. Selective susceptibility reporting is recommended as an effective AMS tool although there is a lack of representative studies investigating the impact of selective susceptibility reporting on antibiotic use. The aim of this study was to investigate the impact of selective susceptibility reporting of Staphylococcus aureus (S. aureus) on antibiotic consumption. Enhancing the use of narrow-spectrum beta-lactam antibiotics such as flucloxacillin/cefazolin/cefalexin is one of the main goals in optimising antibiotic therapy of S. aureus infections.

Methods
This interventional study with control group was conducted at a tertiary care hospital in Germany. During the one-year interventional period susceptibility reports for all methicillin-sensitive S. aureus (MSSA) were restricted to flucloxacillin/cefazolin/cefalexin, trimethoprim-sulfamethoxazole, clindamycin, gentamicin and rifampin/fosfomycin, instead of reporting all tested antibiotics. The impact of implementing selective reporting was analysed by monitoring total monthly antibiotic consumption in our hospital and in a reference hospital (recommended daily dose/100 occupied bed days: RDD/100 BD), as well as on an individual patient level by analysing days of therapy adjusted for bed days (DOT/ 100 BD) for patients with S. aureus bacteremia (SAB) and respectively skin and soft tissue infections (SSTI).

Results
MSSA-antibiograms were acquired for 2836 patients. The total use of narrow-spectrum beta-lactams more than doubled after implementing selective reporting (from 1.2 to 2.8 RDD/100 BD, P < 0.001). The use of intravenous flucloxacillin/cefazolin for SAB rose significantly from 52 to 75 DOT/100 BD (plus 42%), just as the use of oral cefalexin for SSTI (from 1.4 to 9.4 DOT/100 BD, from 3 to 17 of 85/88 patients). Considering the overall consumption, there was no decrease in antibiotics omitted from the antibiogram. This was probably due to their wide use for other infections.

Conclusions
As narrow-spectrum beta-lactams are not widely used for other infections, their increase in the overall consumption of the entire hospital was a strong indicator that selective reporting guided clinicians to an optimised antibiotic therapy of S. aureus infections. On a patient level, this assumption was verified by a significant improved treatment of S. aureus infections in the subgroups of SAB and SSTI. As useful AMS tool, we recommend implementing selective reporting rules into the national/international standards for susceptibility reporting.
The pathology, phylogeny, and epidemiology of Echinococcus ortleppi (G5 genotype): a new case report of echinococcosis in China
Authors: Wang Xu , Zhu Aiya , Cai Hongying , Liu Baixue , Xie Gang , Jiang Rui , Zhang Ji , Xie Nanzi , Guan Yayi , Bergquist Robert , Wang Zhenghuan , Li Yang , Wu Weiping 
Published: November 2021

Abstract
Background
Cystic echinococcosis (CE), caused by the larval stage of the complex Echinococcus granulosus sensu lato (s.l.), is a zoonotic parasitic disease with a high social burden in China. E. ortleppi is a species (formerly genotype 5 of E. granulosus s.l.) with unique epidemic areas (tropical areas), transmission patterns (mainly cattle origin), and pathological characteristics (large and small hook lengths) compared to other species that cause CE. A 19-year-old female patient in an area with no history of echinococcosis in Guizhou Province, China, was diagnosed with E. ortleppi infection in 2019. This study is to understand the source of this human E.ortleppi infection.

Methods
We performed computer tomography (CT) scans, surgical operation, morphological sectioning, molecular diagnosis, phylogenetic analyses, and epidemiological investigation in Anshun City, Guizhou Province, China in 2019.

Results
The patient presented with intermittent distension and pain in the upper abdomen without other abnormal symptoms. Routine blood examination results were normal. However, abdominal CT revealed a fertile cyst with a diameter of approximately 8 cm, uniform density, and a clear boundary, but without an evident cyst wall in the right lobe of the liver. The cyst was fertile, and phylogenetic analyses revealed that the isolates represented a new E. ortleppi genus haplotype. A result of 10‒14 years incubation period with indigenous infection was considered available for the case through the epidemiological survey.

Conclusions
CE due to E. ortleppi infection can be confused with other diseases causing liver cysts, resulting in misdiagnosis. A transmission chain of E. ortleppi may exist or existed in the past in the previously considered non-endemic areas of echinococcosis in southwestern China.

Graphic abstract
Fear of COVID-19 lead to procrastination among Turkish university students: The mediating role of intolerance of uncertainty
Authors: Doğanülkü Hacı Arif , Korkmaz Ozan , Griffiths Mark D. , Pakpour Amir H. 
Published: November 2021

Abstract
Background
The COVID-19 outbreak has not only increased mortality but has also negatively affected mental health among populations across the world. Furthermore, individuals are experiencing uncertainty about their current and future situation because of the pandemic. Therefore, the present study investigated the mediating role of intolerance of uncertainty in the relationship between fear of COVID-19 and procrastination among a sample of Turkish university students.

Methods
Between October and November 2020, 450 university students (291 females and 159 males aged 17 to 24 years) from three state universities in Turkey completed an online survey. Correlation analysis and structural equation modeling methods were employed to examine a model for understanding the general procrastination during COVID-19 pandemic.

Results
The results of the correlation analysis indicated that the fear of COVID-19 was positively correlated with both intolerance of uncertainty (r = .26, p < .001) and procrastination (r = .23, p < .001). The mediation analysis also showed that intolerance of uncertainty had a significant mediating role in the relationship between fear of COVID-19 and procrastination (β = .11, p < .001).

Conclusion
Reducing the fear of COVID-19 and intolerance of uncertainty is likely to contribute to reducing individuals’ procrastination behaviors during the pandemic.
The role of ferroptosis in lung cancer
Authors: Wu Sikai , Zhu Chengchu , Tang Daolin , Dou Q. Ping , Shen Jianfei , Chen Xin 
Published: November 2021

AbstractLung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and women. Ferroptosis is a type of non-apoptotic cell death modality, usually characterized by iron-dependent lipid peroxidation, rather than caspase-induced protein cleavage. Excessive or lack of ferroptosis is associated with a variety of diseases, including cancer and ischaemia-reperfusion injury. Recent preclinical evidence suggests that targeting ferroptotic pathway is a potential strategy for the treatment of lung cancer. In this review, we summarize the core mechanism and regulatory network of ferroptosis in lung cancer cells, and highlight ferroptosis induction-related tumor therapies. The reviewed information may provide new insights for targeted lung cancer therapy.
Modeling the transmission dynamics of racism propagation with community resilience
Authors: Mamo Dejen Ketema 
Published: November 2021

AbstractRacism spreading can have a vital influence on people’s lives, declining adherence, pretending political views, and recruiters’ socio-economical crisis. Besides, Web 2.0 technologies have democratized the creation and propagation of racist information, which facilitated the rapid spreading of racist messages. In this research work, the impact of community resilience on the spread dynamics of racism was assessed. To investigate the effect of resilience-building, new SERDC mathematical model was formulated and analyzed. The racism spread is under control where $$R_0<1$$

R
0

<
1

, whereas persist in the community whenever $$R_0>1$$

R
0

>
1

. Sensitivity analysis of the parameters value of the model are conducted. The rising of transmission and racial extremeness rate provides the prevalence of racism spread. Effective community resilience decline the damages, mitigate, and eradicate racism propagation. Theoretical analysis of the model are backed up by numerical results. Despite the evidence of numerical simulations, reducing the transmission and racial extremeness rate by improving social bonds and solidarity through community resilience could control the spread of racism.
Comprehensive analysis of differences of N6-methyladenosine of lncRNAs between atrazine-induced and normal Xenopus laevis testis
Authors: Qi Xuejie , Geng Xiao , Zhang Juan , Qu Binpeng , Zhang Xin , Jia Qiang , Yin Wenhui , Bo Cunxiang , Liu Yan , Li Hao , Sai Linlin , Han Mingming , Peng Cheng 
Published: November 2021

Abstract
Background
Increasing evidence suggested N6-methyladenosine (m6A) modification is crucial for male germline development. However, m6A modification of lncRNAs gains a little attention in amphibians in recent years. Xenopus laevis (X. laevis) was chosen to be an ideal model organism for testing environmental endocrine disrupting chemicals (EDCs) exposure and resultant effects. Atrazine (AZ) as an endocrine disrupt can effect development of testis in amphibians. Our previous study revealed that m6A is a highly conserved modification across the species.

Results
The results of m6A sequences showed that m6A-methylated lncRNAs enriched in intergenic region in testes of X. laevis. We further examined the differential expression of lncRNAs m6A sites in testes of AZ-exposed and compared with that in animals from control group. The results indicated that up to 198 differentially methylated m6A sites were detected within 188 lncRNAs, in which 89 significantly up-methylated sites and 109 significantly down-methylated sites. Data from KEGG pathway analysis indicated that AZ-affected lncRNAs m6A sites were mainly involved in 10 pathways in which 3 mutual pathways were found in the result of differentially m6A-methylated mRNAs.

Conclusions
These findings suggested that differentially m6A-methylated lncRNAs and these 3 pathways may act on regulatory roles in abnormal testis development of AZ-exposed X. laevis. This study for the first time provides insights into the profile of lncRNAs m6A modifications in amphibian species.