bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pleomorphic Xanthoastrocytoma, Anaplastic Pleomorphic Xanthoastrocytoma, and Epithelioid Glioblastoma: Case Series with Clinical Characteristics, Molecular Features and Progression Relationship
Authors: Lin Zhiying , Yang Runwei , Zheng Haojie , Li Zhiyong , Yi Guozhong , Han Huixia , Wu Qianchao , Qi Songtao , Huang Guanglong 
Published: June 2021

Abstract
Background: Pleomorphic xanthoastrocytoma (PXA), anaplastic pleomorphic xanthoastrocytoma (A-PXA), and epithelioid glioblastoma (E-GBM) show overlapping features. However, little is known about their clinical characteristics, molecular features and relationship with progression. Methods: Fourteen patients diagnosed at Nanfang Hospital from 2016 to 2019 were enrolled, including eleven PXA patients, two A-PXA patients, and one E-GBM patient. All tumour tissue samples of the fourteen patients were examined by immunohistochemical staining (MGMT, VEGF, BRAF-V600E, etc.). The recurrent tumour tissue of the patient with E-GBM arising from A-PXA was screened to detect 11 glioma markers (MGMT, BRAF-V600E, etc.) and chromosome 1p/19q by next-generation sequencing (NGS).Results: The mean age of 13 patients with PXA or A-PXA was 25.4 years; twelve of these patients had tumours at supratentorial regions. VEGF positivity was detected in the tumour samples of 13 patients, MGMT positivity in 10 patients, and BRAF-V600E positivity in 7 patients. For the tumour sample of the E-GBM patient who survived for up to 10 years after the fourth resection, BRAF V600E was wild type in the sample obtained from the first surgery, while it was mutant in the second, third, and fourth surgeries. In contrast, the promoter status of MGMT in the four surgeries was unmethylated. The NGS results showed that the mutation frequencies of BRAF V600E in the second, third and fourth surgeries were 14.06%, 9.13% and 48.29%, respectively.Conclusions: Collectively, the results suggest that patients with A-PXA may relapse multiple times and eventually progress to E-GBM with the BRAF-V600E mutation.
USE OF <sup>177</sup>Lu-PSMA FOR RADIONUCLIDE THERAPY IN PATIENTS WITH CASTRATE-RESISTANT PROSTATE CANCER
Authors: Medvedeva A. A. , Chernov V. I. , Usynin E. A. , Zelchan R. V. , Bragina O. D. , Lushnikova N. A. 
Published: June 2021

Purpose of the study: to present current data regarding challenges in treatment of castration-resistant prostate cancer (CRPC) and the relationship between CRPC and the expression of prostate-specific membrane antigen (psma).Material and Methods. The search for relevant sources was carried out in the Pubmed, elibrary, Medline databases. The review included 43 publications, most of which were published over the past 5 years.Results. Currently, prostate cancer (PC) is one of the most common cancers in men. Moreover, over time, most patients develop resistance to therapy, which significantly worsens the prognosis of the disease. Psma is one of the molecular markers of prostate cancer; a number of studies have demonstrated a direct correlation between the level of psma expression and the tumor grade, stage and aggressiveness. Numerous studies indicate that psma represents an excellent target for radionuclide therapy of prostate cancer. 68Ga or 18F-psma Pet/Ct is the most common method for diagnosing PC. It should be noted that modern trends in the development of nuclear medicine are closely related to theranostics; therefore, the creation of highly specific theranostic pairs for diagnosis and subsequent therapy of malignant tumors is of great significance. The data obtained indicate that 177lu demonstrates the most optimal radiation and physical characteristics for therapeutic radionuclides, while psma-617 is one of the most studied ligands for radionuclide therapy.Conclusion. Currently, there are several studies covering radionuclide therapy with various psmacompounds labeled with 177lu. Radionuclide therapy with 177lu-psma has been shown to be recommended for patients with metastatic CRPC, who have no benefits from alternative therapies or have contraindications to them.
REVIEW OF RESEARCH ON THE RELATIONSHIP BETWEEN CIRCADIAN RHYTHMS AND CARCINOGENESIS USING ANIMAL MODELS
Authors: Kireeva G. S. , Gubareva E. A. , Maydin M. A. , Panchenko A. V. , Tyndyk M. L. , Fedoros E. I. , Kruglov S. S. , Osetnik V. K. , Anisimov V. N. 
Published: June 2021

Purpose of the study: to review in vivo studies on the relationship and role of various molecular genetic components of the circadian rhythm system in the initiation and development of malignant neoplasms. in contrast to clinical and epidemiological studies, animal models, including transgenic animal models, can model various changes and disturbances in the activity of clock genes and track the results of these changes.Material and Methods. the review includes data from studies carried out over the past 10 years in animal models, studying the mechanisms and effects of disturbances in the system of circadian rhythms related to the formation and development of tumors. the data sources for the review were the Medline, embase and scopus databases.Results. analysis of the literature has shown that interference with the work of the «biological clock» by changing the light cycle, disrupting the expression of clock genes and other manipulations is a factor predisposing to the development of tumors. in tumors of various types, the expression of clock genes is often mismatched, and it is unclear at what stage of their formation this occurs. in addition, the development of tumors disrupts the circadian homeostasis of the body. there are three key areas of research aimed at studying the role of circadian rhythms in tumor development: disturbance of circadian rhythms as a carcinogenic factor, disturbances in the clock gene system in a tumor, disturbances in the clock gene system of the whole organism, provoked by tumor development.Conclusion. the results of studies on animal models demonstrate that the relationship between the disturbance of circadian rhythms and the tumor process is complex since the causal relationship has not yet been studied. in this regard, the prospect of targeted pharmacological correction of circadian rhythms in clinical practice in cancer patients does not seem to be the nearest one.
COVID-19 Global Pandemic Fight by Drugs: A Mini-Review on Hope and Hype
Authors: Tekale Sunil , Gore Vishnu , Kendrekar Pravin , Thore Shivaji , Kótai László , Pawar Rajendra 
Published: June 2021

:
Coronavirus disease 2019 (Covid-19), a serious disease caused by the Severe Acute Respiratory
Syndrome-Corona Virus-2 (SARS-CoV-2), was firstly identified in the city of Wuhan of
China in December 2019, which then spread and became a global issue due to its high transmission
rate. To date, the outbreak of COVID-19 has resulted in infection to 230,868,745 people and the death
of 4,732,669 patients. It has paralyzed the economy of all the countries worldwide. Considering the
possible mutations of SARS-CoV-2, the current medical emergency requires a longer time for drug
design and vaccine development. Drug repurposing is a promising option for potent therapeutics
against the pandemic. The present review encompasses various drugs or appropriate combinations of
already FDA-approved antimalarial, antiviral, anticancer, anti-inflammatory, and antibiotic therapeutic
candidates for use in the clinical trials as a ray of hope against COVID-19. It is expected to deliver
better clinical and laboratory outcomes of drugs as a prevention strategy for the eradication of the disease.
Development of Jacketing Machine
Authors: Giripunje Manish 
Published: June 2021

Flat Belt is manufactured almost all over the world. In the Transmission Industries, Flat Belt is almost available in every part. In modern trend demand has been significantly increased. To fulfil the increased demand for flat belt, jacketing operation of flat Belt must be paced up. In traditional jacketing processes which are carried out manually take more time, labour work and also provide damage to industry growth. To overcome this and to minimize stress on workers, an attempt has been made to design a jacketing machine for flat belt, which is simple in design and can be handled by the common man. The demand for a flat belt jacketing machine is higher and it is time to respond to the problem raised. Designing and fabricating such types of functional machines is important to save money instead of investing money and time buying labor and conventional tool. Since metal resources are declining and their products are very expensive as compared to rubber, it’s preferable to use Rubber flat belts rather than using chains for transmission. As per the studies, it is easier and economical to use belt drives replacing chain drives and it is good for the future without disturbing the ecosystem.	Study shows that while analyzing the force and power for machines the designer takes the help of analysis software. The cost of software for analysis is high. So there is requirement to find simple formula. In this paper the various theories regarding bending are reviewed, formulae for force and power calculation are collected and finally a case study is taken where we have put together all the results of these formulae. Our main concern is to reduce the human effort required in jacketing of flat belt and also to save the time, labour work, lead time, and move towards the partial automation. The machine has been designed and developed to minimize the cost of production and increase the efficiency.
Climate Change Impact and Conservation on Environment
Authors: Pandey Diwaker 
Published: June 2021

Climate-Change affecting unfavorably because of upward push in worldwide temperature alteration and that too alarmingly. Ancient Air bubbles buried in Antarctic Ice to shed more light on Global Warming. It has happened in the North-Atlantic and may happen again. According to scientists, a dangerous atmospheric deviation could prompt prolonged chill and move the Earth towards a brand new age and a new defined climate that would be an effect of the worldwide environmental change. On such conditions James White, a geography educator at Colorado University, Boulder, not engaged with the investigation, said that albeit the ice-age proof showed that degrees of CO2 and further ozone harming substances rose and fell in reaction to heating and cooling , the gases could clearly take the lead as well. Global Climate withinside the fresh past: In the 90’s decades there has stood an experience and witnessing of the extremes of various weather events. In the warmer temperature of century was recorded and a share of the majority noticeably terrible floods all in the course of the planet. The one such inconstancy is the staggering dry period in the Sahel-area which lies in South-of-Sahara desert, from 1967-1977. During the 1930’s there were severe drought that occurred in the south-western Great Plains of the U.S which was described as DUST BOWL. The after-effects of the Global-Climate-Change are severe and tell us about the various impacts. They are:- A.	Crop yield or Crop failures, B.	Floods, C.	Migration of people. These are various influences of the Global-Climate-Change that effect the biosphere from many ways as Climate-Change directly affects the biosphere which is the only sphere wherein lifestyle exists and where life can exist.
EKSPLORASI BAKTERI LOKAL PENGHASIL ANTIMIKROBA DI CAGAR ALAM TANJUNG API TELUK TOMINI SULAWESI TENGAH, INDONESIA
Authors: Millang Alwi , Widiawati  , Umrah  , Lambui Orryani 
Published: July 2021

ABSTRACT
Tanjung Api Nature Reserve is a headland located in Tomini Bay Ampana District Tojo Una-Una Regency, Central Sulawesi Province. This study aims to obtain local bacteria isolates as antimicrobial producers. The method used in this research is purposive sampling and screening method using "Agar Dua Lapis" (Double Layer Method). Testing antimicrobial potency using the method to make Well Diffusion (well) using three pathogens of microbial tests (S. aureus, E. coli, and C. albicans). In each well hole is given 500 μL of bacterial isolates each and incubated at a temperature of 37 oC for 24 hours and continued for 48 hours. The observed parameter is a clear zone formed around the well. Antimicrobial-producing bacteria screening results. obtained as many as 24 isolates of bacteria. Testing of antimicrobial potency by looking at the resulting inhibitory zone is obtained five isolates namely S2U1, S3U3, S7U3, S9U3, and S10U3 are the highest isolates of the bland zone of 12.25 mm but only against S. aureus, while S9U3 is the best isolate because it is able to inhibit the four test microbes namely S. aureus by 5.50 mm, E. coli 9.25 mm, and C. albicans 5.50 mm.

Keywords: Exploration of bacteria, antimicrobials, and Nature Reserve
Hallazgo histopatológico de Strongyloides stercoralis en enfermedad de Crohn: reporte de caso
Authors: Muñoz Cedeño Ruben  Gustavo , Naranjo Raffo Linda Patricia , Rodríguez Chica Gema Nathalye , Alvarado Gallo Virgilio 
Published: June 2021

Caso clínico: se describe un caso clínico poco frecuente en un paciente inmunocomprometido con hallazgo histopatológico de infestación parasitaria. Es un paciente masculino de edad media que habita en zona subtropical con diagnóstico de enfermedad de Crohn tratado con corticoide e inmunomoduladores, presentaba dolor abdominal y anemia crónica de 1 año de evolución, analítica negativa para parásitos, reactantes de fase aguda normales, gastroscopia y colonoscopia previas (6 meses) sin hallazgos relevantes. Por la persistencia del cuadro clínico se repitieron los estudios endoscópicos en los que se visualizaron hemorragias subepiteliales con resultados histopatológicos de Strongyloides stercoralis.
Conclusión: en el contexto de un paciente inmunocomprometido, en zona endémica y con evolución tórpida, debe obligar a realizar un diagnóstico diferencial en el que se debe sospechar siempre de infestación parasitaria. Aunque la endoscopia no se necesita para el diagnóstico de estrongiloidiasis, su intervención puede ser oportuna.
Tumores estromales gastrointestinales (GIST) gástricos, serie de casos
Authors: Oliveros Wilches Ricardo , Pinilla Morales Raúl , Sánchez Pedraza Ricardo , Contreras Ramos Haylmanrth Fernán 
Published: June 2021

Introducción: los tumores estromales gastrointestinales (GIST) representan hasta el 2 % de las neoplasias gastrointestinales, estos aparecen en cualquier parte del tracto gastrointestinal y son encontrados más frecuentemente en el estómago (60 %). El diagnóstico se realiza por la expresión de un receptor de factor de crecimiento de tirosina-cinasa, antígeno de diferenciación (CD) 117, lo que lo diferencia de los otros tumores mesenquimales como leiomiomas, leiomiosarcomas, leiomioblastomas y tumores neurogénicos, que no expresan esta proteína.
Objetivo: el objetivo de nuestro trabajo es caracterizar los GIST de localización gástrica con respecto a su presentación clínica, diagnóstico, manejo, recurrencia y supervivencia.
Métodos: se trata de un estudio observacional, retrospectivo basado en una serie de casos. Se realizó una extracción de la información por medio de la revisión de las historias clínicas de los pacientes con GIST gástricos en un centro oncológico de Bogotá entre enero de 2005 y diciembre de 2015. La información recolectada incluyó tipo de manejo y abordaje quirúrgico, localización, tamaño, índice mitótico y clasificación de riesgo.
Resultados: se encontraron 31 pacientes con diagnóstico de GIST gástrico. La edad media fue de 62,3 años, con una mediana de 61 años. De los 31 pacientes, 18 fueron mujeres y 13 hombres. El tiempo de seguimiento estuvo entre un mínimo de 2,4 meses y un máximo de 214 meses, La mediana de seguimiento fue de 36 meses.
Conclusiones: los GIST son tumores potencialmente malignos, y el de localización gástrica es el más frecuente. El diagnóstico y tratamiento dependen de su tamaño y localización dentro del estómago. El manejo es variado y consiste en la resección quirúrgica, en la que los procedimientos son mínimamente invasivos, en combinación con la endoscopia, que son una buena alternativa al tratamiento abierto hasta que haya necesidad de terapia sistémica.
Calidad de la biopsia hepática en diez instituciones hospitalarias de Bogotá
Authors: Prieto Ortiz Jhon Edison , Garzón-Orjuela Nathaly , Sánchez Pardo Santiago , Prieto Ortíz Robin Germán , Ochoa Díaz Andrés Felipe , Eslava-Schmalbach Javier H 
Published: June 2021

Introducción: La biopsia hepática es la prueba de oro para el diagnóstico de las enfermedades que comprometen el hígado, una muestra adecuada y una muy buena lectura son elementos que determinan la utilidad de la prueba y el impacto en la toma de decisiones.
Objetivo: Evaluar la calidad de las biopsias hepáticas a partir de la frecuencia de un “diagnóstico definitivo” en la lectura de las mismas y su relación con el número de espacios porta y su longitud informada.
Materiales y métodos: Estudio observacional retrospectivo basado en registros, entre el 1 de enero del 2010 y el 30 de julio del 2017. Se realizó biopsia hepática, revisión de historias clínicas y evaluación del resultado de patología.
Resultados: Se incluyeron 659 informes de patología de 10 instituciones. El porcentaje de reporte de espacios porta varió entre un 15% y un 87.4 %. La mediana de longitud de la biopsia fue de 15 mm (RIQ 10-20) y la del número de espacios porta fue de 10 (RIQ 7-15). Los diagnósticos definitivos se presentaron entre 35% y 69 %, diagnósticos probables entre 25% y 63 % y sin diagnostico entre un 5% y 31.8%. En el resultado de la regresión logística del diagnóstico se encontró que el número de espacios porta presentó un OR de 1.10 (IC 95%1.04-1.17) y la longitud OR 1.76 (1.10-2.82),
Conclusiones: En Bogotá existen 3 instituciones hospitalarias con un rendimiento en el diagnóstico en cuanto a lectura de biopsias hepáticas por encima del 60 %. El diagnóstico definitivo en la biopsia hepática se asoció en este estudio a la presencia de un cilindro de tejido hepático de longitud y número de espacios porta adecuados.
Upaya Meningkatkan Keaktifan Siswa Dalam Hal Ketepatan Waktu Mengerjakan Tugas Saat Pembelajaran Online Di Masa Pandemi Covid-19
Authors: Sarjino Sarjino 
Published: June 2021

This study aims to improve the timeliness of students in collecting assignments on google form for the online method of Light Vehicle Engineering Chassis Maintenance on the subject of Diagnosing Automatic Transmission Damage for Class XII odd semester SMK Wiworotomo Purwokerto Pelajar 2020/2021. The data obtained include data on student learning outcomes tests for each cycle, data from observations of teacher activities and data from observations of student activities. Based on the results of the study it can be concluded that by maximizing the WA group class before and after learning can improve the timeliness of students in doing assignments on the google form material Diagnosing Automatic Transmission Damage Class XII TKRO SMK Wiworotomo Purwokerto Academic Year 2020/2021.
Penelitian ini bertujuan untuk meningkatkan ketepatan waktu siswa dalam mengumpulakn tugas pada google form mata pelajaran Pemeliharaan Sasis Pemindah Tenaga Teknik Kendaraan Ringan metode daring pada materi Mendiagnosis Kerusakan transmisi Otomtais Kelas XII semester gasal SMK Wiworotomo Purwokerto Pelajaran 2020/2021. Data yang diperoleh antara lain tentang data tes hasil belajar siswa setiap siklusnya, data hasil observasi aktifitas guru dan data hasil observasi aktifitas siswa. Berdasarkan hasil penelitian dapat disimpulkan bahwa dengan memaksimalkan WA group kelas sebelum dan sesudah pembelajaran dapat meningkatkan ketepatan waktu siswa dalam mengerjakan tugas di google form materi Mendiagnosa Kerusakan Transmisi Otomatis Kelas XII TKRO SMK Wiworotomo Purwokerto Tahun Pelajaran 2020/2021.
Rancang Bangun Alat Skir Katup Pada Mobil Menggunakan Pemutar Motor Listrik Dengan Pengaturan Dimmer AC
Authors: Pratama Yodi Agus , Purwanto Wawan 
Published: June 2021

This research discusses the design of valve skir tool. The purpose of this research is to explain the process of designing and manufacturing as well as testing the valve screw by knowing the ratio of the thickness of the valve margins from the results of the valve clearance. This type of research is development and research, the researcher examines and tests the performance of the tool. The object of this research is to know the ratio of the thickness of the valve margins if the rpm is increased gradually and the time during drilling continues to increase, using the Toyota Corona type 12 R cylinder head and valve. Based on the research that has been done, it can be concluded that the effective rpm and time or rpm and time Recommended for conducting valve inspections is at rpm 5000 minutes to 15, rpm 6000 and rpm 7000 minutes 5. The reason is because at that rpm and time the rotation is stable and from the results of checking the valve there is no leakage.
Penelitian ini membahas tentang rancang bangun alat skir katup. Tujuan penelitian ini adalah menjelaskan proses perancangan dan pembuatan serta melakukan uji coba alat skir katup dengan mengetahui perbandingan tebal margin katup dari hasil penyekiran katup. Jenis penelitian ini adalah pengembangan dan penelitian, peneliti meneliti dan melakukan uji coba kinerja alat. Objek penelitian ini adalah megetahui perbandingan ketebalan margin katup jika rpmnya dinaikkan secara bertahap serta waktu selama penyekiran terus bertambah, menggunakan kepala silinder dan katup Toyota Corona tipe 12 R. Berdasarkan penelitian yang telah dilakukan maka dapat disimpulkan bahwa rpm dan waktu yang efektif atau rpm dan waktu yang direkomendasikan untuk melakukan penyekiran katup adalah pada rpm 5000 menit ke 15, rpm 6000 dan rpm 7000 menit ke 5. Alasannya yaitu karena pada rpm dan waktu tersebut putarannya stabil dan dari hasil penyekiran katup tidak terjadi kebocoran.
Pengaruh Investment Opportunity Set, Pertumbuhan Perusahaan Dan Profitabilitas Terhadap Nilai Perusahaan
Authors: Wulanningsih Srirahayu , Agustin Henri 
Published: June 2021

This study was to analyze the Investment Opportunity Set (IOS), Growth, Profitability on firm value. The research object was the entire industrial sector of used in this study are annual reports in property and real estate companies on the indonesia stock exchange (idx) in the period 2014-2018. The method of taking data samples using purposive sampling method based on certain criteria. Based on the retrieval method obtained a sample of 36 companies. Hypothesis testing in this study uses multiple linear regression analysis. The results show that Investment Opportunity Set (IOS), Profitability have a positive influence on firm value and Growth has no influence on firm value.
Pengaruh Gender, Pengalaman, Keahlian, Situasi Audit Dan Etika Terhadap Skeptisisme Profesional Auditor
Authors: Raynaldi Rafli , Afriyenti Mayar 
Published: June 2021

This study aims to determine the effect of Gender, Experience, Expertise, Audit Situation, and Ethics on the auditor’s professional skepticism. The population in this study is the auditor at the Public Accountant Office in the City of Padang. The population in Padang City is 7 Public Accountants with 45 auditors. The sample in this study uses the total sampling method because the total population is less than 100, then the entire populaton is sampled. The data used are primary data. Data collection techniques are used by means of Library Studies and Field Research. Data analysis method used is multiple linear regression. The results of this study indicate that gender affects auditor professuonal skepticism, expertise has a significant effect on the accuracy of auditor opinion, the audit situation has a effect on the accuracy of auditor opinion, the audit siuation has a positive effect on auditor skepticism and ethics has a significant effect on auditor skepticism.