bluuebunny/crossref_metadata_2025_split huggingface dataset:
The predictive and incremental validity of ADHD beyond the VRAG-R in a high-risk sample of young offenders
Authors: Gregório Hertz Priscilla , Müller Marcus , Barra Steffen , Turner Daniel , Rettenberger Martin , Retz Wolfgang 
Published: December 2021

AbstractThe VRAG-R is a well-established actuarial risk-assessment instrument, which was originally developed for assessing violent recidivism risk in adult male offenders. Whether or not the VRAG-R can also predict violent recidivism in young offenders is unclear so far. In the emergence of juvenile offending, attention-deficit/hyperactivity disorder (ADHD) seems to be of major importance suggesting that it could be relevant for risk assessment as well. Thus, we examined the predictive accuracy of the VRAG-R in a high-risk sample of N = 106 (M = 18.3 years, SD = 1.8) young offenders and assessed the incremental predictive validity of ADHD symptomatology beyond the VRAG-R. Within a mean follow-up time of M = 13 years (SD = 1.2), n = 65 (62.5%) young offenders recidivated with a violent offense. We found large effect sizes for the prediction of violent and general recidivism and re-incarcerations using the VRAG-R sum scores. Current ADHD symptomatology added incremental predictive validity beyond the VRAG-R sum scores concerning the prediction of general recidivism but not of violent recidivism. The results supported the use of the VRAG-R for predicting violent recidivism in young offenders. Because ADHD symptomatology improves the predictive performance of the VRAG-R regarding general recidivism, we argue that addressing ADHD symptoms more intensively in the juvenile justice system is of particular importance concerning a successful long-term risk management in adolescents and young adults.
Lipid lowering therapy in primary and secondary prevention in Austria: are LDL-C goals achieved?
Authors: Siostrzonek Peter , Brath Helmut , Zweiker Robert , Drexel Heinz , Hoelzl Robert , Hemetsberger Margit , Ray Kausik K. 
Published: December 2021

Summary
Background
Cardiovascular disease (CVD) is the most frequent cause of death in Austria. The European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines recommend intensive lipid lowering therapy (LLT) in patients at high or very high CV risk. Lipid management and achievement of low-density lipoprotein cholesterol (LDL-C) goals in Austria have not recently been assessed.

Methods
Subgroup analysis for Austria of a European 18 country, cross-sectional, observational study. Patients received LLT for primary (PP) or secondary prevention (SP). Data including LLT in the preceding 12 months and most recent LDL‑C were collected during a single visit between June 2017 and November 2018. Achievement of the risk-based 2016 and 2019 ESC/EAS LDL‑C goal while receiving stabilized LLT was assessed.

Results
A total of 293 patients were enrolled from 8 Austrian sites, of which 200 (PP = 104, SP = 96) received stabilized LLT at the LDL‑C measurement date. Overall, 58% (71% PP, 43% SP) and 38% (52% PP, 23% SP) achieved the risk-based 2016 and 2019 goals, respectively. Most patients received moderate-intensity statin monotherapy (46%), while 34% used high-intensity statin monotherapy. Combination therapy of moderate/high-intensity statin with ezetimibe (12%), or proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors with statin ± ezetimibe (1%), was used infrequently.

Conclusion
The current Austrian routine lipid management using mainly moderate-intensity or high-intensity statin monotherapy is insufficient to attain ESC/EAS guideline goals, in particular the more stringent 2019 recommendations, a situation comparable to other participating European countries. In addition to switching to and optimizing doses of high-intensity statins, a combination with ezetimibe or PCSK9 inhibitors will be needed in many cases.
Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients
Authors: Winker Matteo , Stössel Sandra , Neu Marie Astrid , Lehmann Nadine , El Malki Khalifa , Paret Claudia , Joisten Niklas , Bloch Wilhelm , Zimmer Philipp , Faber Jörg 
Published: December 2021

AbstractWhile exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise on the inflammation markers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic-immune-inflammation index (SII) and associations to patient-reported-outcomes in CCPs in a randomized-controlled trial. Results show associations between inflammation markers and patient-reported outcomes. Compared to the control group, SII was significantly reduced following exercise (p=0.036). Anti-inflammatory effects of exercise are also present in CCPs and may underlie exercise-induced benefits on symptoms. Clinical Trial Registration Number: NCT02612025
Virtual Reality Biofeedback in Health: A Scoping Review
Authors: Lüddecke Robin , Felnhofer Anna 
Published: December 2021

AbstractOver the past decades, virtual reality (VR) has found its way into biofeedback (BF) therapy programs. Using VR promises to overcome challenges encountered in traditional BF such as low treatment motivation, low attentional focus and the difficulty of transferring learnt abilities to everyday life. Yet, a comprehensive research synthesis is still missing. Hence, this scoping review aims to provide an overview over empirical studies on VR based BF regarding key outcomes, included samples, used soft- and hardware, BF parameters, mode of application and potential limitations. We systematically searched Medline, PsycINFO, Scopus, CINAHL, Google Scholar and Open Grey for empirical research. Eighteen articles met the inclusion criteria. Samples mostly consisted of healthy (44.4%) and/or adult (77.7%) participants. Outcomes were mainly anxiety (44.4%), stress (44.4%) or pain reduction (11.1%), which were reduced by the VR-BF interventions at least as much as by classical BF. Participants in VR-BF interventions showed higher motivation and involvement as well as a better user experience. Heart rate or heart rate variability were the most frequently used BF parameters (50.0%), and most VR-BF interventions (72.2%) employed a natural environment (e.g., island). Currently, there is no clear evidence that VR-BF is more effective than traditional BF. Yet, results indicate that VR-BF may have advantages regarding motivation, user experience, involvement and attentional focus. Further research is needed to assess the specific impact of VR and gamification. Also, testing a broader range of clinical and younger samples would allow more far-reaching conclusions.
Associations Between Traumatic Stress, Brain Volumes and Post-traumatic Stress Disorder Symptoms in Children: Data from the ABCD Study
Authors: Bustamante Daniel , Amstadter Ananda B. , Pritikin Joshua N. , Brick Timothy R. , Neale Michael C. 
Published: December 2021

AbstractReduced volumes in brain regions of interest (ROIs), primarily from adult samples, are associated with posttraumatic stress disorder (PTSD). We extended this work to children using data from the Adolescent Brain Cognitive Development (ABCD) Study® (N = 11,848; Mage = 9.92). Structural equation modeling and an elastic-net (EN) machine-learning approach were used to identify potential effects of traumatic events (TEs) on PTSD symptoms (PTSDsx) directly, and indirectly via the volumes 300 subcortical and cortical ROIs. We then estimated the genetic and environmental variation in the phenotypes. TEs were directly associated with PTSDsx (r = 0.92) in children, but their indirect effects (r < 0.0004)—via the volumes of EN-identified subcortical and cortical ROIs—were negligible at this age. Additive genetic factors explained a modest proportion of the variance in TEs (23.4%) and PTSDsx (21.3%), and accounted for most of the variance of EN-identified volumes of four of the five subcortical (52.4–61.8%) three of the nine cortical ROIs (46.4–53.3%) and cerebral white matter in the left hemisphere (57.4%). Environmental factors explained most of the variance in TEs (C = 61.6%, E = 15.1%), PTSDsx (residual-C = 18.4%, residual-E = 21.8%), right lateral ventricle (C = 15.2%, E = 43.1%) and six of the nine EN-identified cortical ROIs (C = 4.0–13.6%, E = 56.7–74.8%). There is negligible evidence that the volumes of brain ROIs are associated with the indirect effects of TEs on PTSDsx at this age. Overall, environmental factors accounted for more of the variation in TEs and PTSDsx. Whereas additive genetic factors accounted for most of the variability in the volumes of a minority of cortical and in most of subcortical ROIs.
Relationships between chemical composition, antioxidant activity and genetic analysis with ISSR markers in flower buds of caper plants (Capparis spinosa L.) of two subspecies spinosa and rupestris of Spanish cultivars
Authors: Grimalt Mar , García-Martínez Santiago , Carbonell Pedro , Hernández Francisca , Legua Pilar , Almansa María S. , Amorós Asunción 
Published: December 2021

AbstractGenetic diversity and variability between populations is essential for the long-term survival of plant species as well as their adaptation to different habitats. The Capparis spinosa L. has two subspecies in Spain, spinosa with stipules thorny and rupestris without them. In Spain, the subspecies used for its cultivation is spinosa, which is difficult to manipulate due to its stipules thorny. The capers, unripe fruits and tender shoots are used as food. The caper plant is a rich source of phenolic compounds, due to that many flavonoids have been found in different parts of caper plant and in high quantities, which indicates that it is a good source of functional compounds both as food and for nutraceutical applications. There are no published works on the differences in biochemical and functional compounds of both subspecies, so in this work 32 varieties have been genetically analyzed to know their subspecies. Afterwards, various biochemical and functional parameters have been analyzed to find out if they present differences between both subspecies. From the results of the biochemical and functional parameters studied, there are no difference between the spinosa and rupestis subspecies, in all the parameters studied, except chlorophylls. There was more difference between the results of the subspecies spinosa among them, than with the subspecies rupestris. For all this, it can be concluded that the rupestris subspecies that does not present stipules thorniness can be cultivated, instead of the spinosa subspecies that does present them, without losing functional or nutritional characteristics of the caper buds.
Brain–computer interfaces for human gait restoration
Authors: Nenadic Zoran 
Published: December 2021

AbstractIn this review article, we present more than a decade of our work on the development of brain–computer interface (BCI) systems for the restoration of walking following neurological injuries such as spinal cord injury (SCI) or stroke. Most of this work has been in the domain of non-invasive electroencephalogram-based BCIs, including interfacing our system with a virtual reality environment and physical prostheses. Real-time online tests are presented to demonstrate the ability of able-bodied subjects as well as those with SCI to purposefully operate our BCI system. Extensions of this work are also presented and include the development of a portable low-cost BCI suitable for at-home use, our ongoing efforts to develop a fully implantable BCI for the restoration of walking and leg sensation after SCI, and our novel BCI-based therapy for stroke rehabilitation.
When the Evidence Is Incorrect: an Exploration of What Happens When Interviewers Unwittingly Present Inaccurate Information in Interviews with Suspects
Authors: Beek Martijn van , Bull Ray , Chen Melissa 
Published: December 2021

AbstractSkillfully presenting evidence/information to suspects is one of the few interviewing techniques that increases the likelihood of guilty suspects providing information or making a confession, without making innocent ones do so as well. It is important that this evidence/information is correct, since deliberately disclosing incorrect evidence poses some risks. Also, in real-life interviews, police interviewers may unwittingly disclose incorrect evidence, for example when a witness was mistaken and provided the police with incorrect information. The present study examined the behavior of fifty police interviewers in interviews with “suspects” of a scripted crime: what is their response when the interviewees try to explain to them that some of the evidence/information just disclosed by them is incorrect? Eleven interviewers responded adaptively (by actively picking up on this new information), 35 responded in a neutral way and four responded maladaptively (by discrediting the interviewee’s claim). Experience and a full interview training had a significant negative relationship with adaptiveness. These results indicate that, when preparing and conducting interviews with suspects, greater awareness is needed of the possibility that some of the evidence/information that is to be disclosed could be incorrect, and therefore it is crucial that suspects’ responses which suggest such may be the case are taken into account.
White paper on peanut allergy: treatment pathway
Authors: Klimek Ludger , Lange Lars , Blum Lea Alexandra , Klimek Felix , Nemat Katja , Reese Imke , Blumchen Katharina 
Published: December 2021

SummaryBackgroundPeanuts are a member of the legume family (botanical family Leguminosae) and peanut allergies are the most common cause of food anaphylaxis in many countries. The prevalence of peanut allergy is increasing.MethodsExperts from Germany and Austria performed a standardized literature search and published their consensus recommendations in a White Paper on Peanut Allergy, which this care pathway is based upon, thus, providing a comprehensive diagnosis and treatment algorithm.ResultsThe most important diagnostic key elements include a detailed clinical medical history, evidence of peanut-specific sensitization by means of skin prick testing and/or in vitro determination of the peanut (extract)-specific IgE and/or the molecular component diagnostics (most important Ara h 2-specific IgE, sometimes also Ara h1-, 3-, 6-, 8- and 9-specific IgE) as well as the gold standard, the double-blind, placebo-controlled food challenge. The diagnostic algorithms were created for the following constellations: Suspected primary peanut allergy with a clear history of systemic immediate-type reaction, suspected primary peanut allergy with questionable symptoms, suspected secondary (possibly pollen-associated) peanut allergy with a history of solely oropharyngeal symptoms and incidental finding of sensitization and no peanut ingestion so far.ConclusionsAfter established diagnosis the standard of care is counseling to avoid peanut contact and prescription of emergency medications (oral antihistamines, oral steroids, inhaled β2-agonists, injectable intramuscular epinephrine) as needed. Instruction on the use of these emergency medications should be provided. A preparation for oral immunotherapy (OIT) for 4 to 17 years old peanut allergic children/ adolescents has been recently approved by the regulatory authorities. OIT for peanut allergy shows high efficacy and an acceptable safety profile, improves quality of life, and health economic aspects. Thus it offers a therapeutic option for peanut allergic children and adolescents.
Coalescence of black hole–neutron star binaries
Authors: Kyutoku Koutarou , Shibata Masaru , Taniguchi Keisuke 
Published: December 2021

AbstractWe review the current status of general relativistic studies for coalescences of black hole–neutron star binaries. First, high-precision computations of black hole–neutron star binaries in quasiequilibrium circular orbits are summarized, focusing on the quasiequilibrium sequences and the mass-shedding limit. Next, the current status of numerical-relativity simulations for the merger of black hole–neutron star binaries is described. We summarize our understanding for the merger process, tidal disruption and its criterion, properties of the merger remnant and ejected material, gravitational waveforms, and gravitational-wave spectra. We also discuss expected electromagnetic counterparts to black hole–neutron star coalescences.
FURTHER CONSIDERATIONS FOR THE AUTHENTICATION OF THE PEKING UNIVERSITY CANG JIE PIAN: WITH BRIEF DIGRESSION ON THE SO-CALLED “HAN BOARD” WITNESS
Authors: Foster Christopher J. 
Published: December 2021

AbstractOver the past few years, additional evidence has surfaced that supplements my prior authentication of the Peking University Han strips, and in particular the *Cang Jie pian 蒼頡篇 manuscript from this collection. The present article surveys this fresh evidence, including confirmation of spiraling verso lines on the archaeologically excavated Shuihudi 睡虎地 Han strips, as well as further textual parallels, both with a previously unidentified Cang Jie pian strip from Niya 尼雅, and also with newly published content from the Shuiquanzi 水泉子 *Cang Jie pian. The article also critically examines in greater detail the methodology previously employed to authenticate the Peking University Han strips. Limitations are acknowledged, both in regard to supporting negative appraisals, and in the determination of “novelty” for manuscript features. To demonstrate these issues, the article analyzes a conflict between the Peking University and Shuiquanzi Cang Jie pian manuscripts and introduces the publication of the so-called “Han board” *Cang Jie pian witness largely unknown to the field before.
The Democratic Cost of Consecutive Re-election and Presidential Term-Limit Evasion in Latin America
Authors: Kouba Karel , Pumr Jan 
Published: December 2021

AbstractDespite theoretical arguments suggesting the strong effects of presidential term limits and re-election on democracy, there is surprisingly little empirical evidence to evaluate them. We test both the effect on democracy of the existence of a consecutive re-election rule and of reforms introducing it for incumbent presidents. Using evidence from Latin American countries between 1945 and 2018, we test their relationship to both vertical and horizontal accountability. A synthetic control method is employed to account for the effect of term-limit reforms, and time-series cross-section models for modelling the association with the re-election rule. Both vertical and horizontal accountability as well as the quality of democracy are eroded by term-limit evasion reforms in most countries and strengthened in none between 1990 and 2018. Allowing presidents to run for re-election – relative to term-limited ones – is consistently associated with weak democratic outcomes.
Outbreak of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in hospitalized hemodialysis patients: An epidemiologic and genomic investigation
Authors: Marvil Charles E. , Babiker Ahmed , Preston Aaron , Webster Andrew S. , Guarner Jeannette , Love Kari , Ghonim Elham , Rebolledo Paulina A. , Wang Yun F. , Arthur Robert A. , Johnston H. Richard , Waggoner Jesse J. , Piantadosi Anne , Jacob Jesse T. 
Published: December 2021

AbstractWe performed an epidemiological investigation and genome sequencing of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) to define the source and scope of an outbreak in a cluster of hospitalized patients. Lack of appropriate respiratory hygiene led to SARS-CoV-2 transmission to patients and healthcare workers during a single hemodialysis session, highlighting the importance of infection prevention precautions.
Explorative gradient method for active drag reduction of the fluidic pinball and slanted Ahmed body
Authors: Li Yiqing , Cui Wenshi , Jia Qing , Li Qiliang , Yang Zhigang , Morzyński Marek , Noack Bernd R. 
Published: December 2021

We address a challenge of active flow control: the optimization of many actuation parameters guaranteeing fast convergence and avoiding suboptimal local minima. This challenge is addressed by a new optimizer, called the explorative gradient method (EGM). EGM alternatively performs one exploitive downhill simplex step and an explorative Latin hypercube sampling iteration. Thus, the convergence rate of a gradient based method is guaranteed while, at the same time, better minima are explored. For an analytical multi-modal test function, EGM is shown to significantly outperform the downhill simplex method, the random restart simplex, Latin hypercube sampling, Monte Carlo sampling and the genetic algorithm. EGM is applied to minimize the net drag power of the two-dimensional fluidic pinball benchmark with three cylinder rotations as actuation parameters. The net drag power is reduced by 29 % employing direct numerical simulations at a Reynolds number of

$100$

based on the cylinder diameter. This optimal actuation leads to 52 % drag reduction employing Coanda forcing for boat tailing and partial stabilization of vortex shedding. The price is an actuation energy corresponding to 23 % of the unforced parasitic drag power. EGM is also used to minimize drag of the

$35^\circ$

slanted Ahmed body employing distributed steady blowing with 10 inputs. 17 % drag reduction are achieved using Reynolds-averaged Navier–Stokes simulations at the Reynolds number

$Re_H=1.9 \times 10^5$

based on the height of the Ahmed body. The wake is controlled with seven local jet-slot actuators at all trailing edges. Symmetric operation corresponds to five independent actuator groups at top, middle, bottom, top sides and bottom sides. Each slot actuator produces a uniform jet with the velocity and angle as free parameters, yielding 10 actuation parameters as free inputs. The optimal actuation emulates boat tailing by inward-directed blowing with velocities which are comparable to the oncoming velocity. We expect that EGM will be employed as efficient optimizer in many future active flow control plants as alternative or augmentation to pure gradient search or explorative methods.
The Creative Advance Must Be Defended: Miscegenation, Metaphysics, and Race War in Jan Smuts’s Vision of the League of Nations
Authors: KRIPP JACOB 
Published: December 2021

This paper argues that the idea of global peace in early twentieth-century liberal international order was sutured together by the threat of race war. This understanding of racial peace was institutionalized in the League of Nations mandate system through its philosophical architect: Jan Smuts. I argue that the League figured in Smuts’s thought as the culmination of the creative advance of the universe: white internationalist unification and settler colonialism was the cosmological destiny of humanity that enabled a racial peace. In Smuts’s imaginary, the twin prospect of race war and miscegenation serves as the dark underside that both necessitates and threatens to undo this project. By reframing the problem of race war through his metaphysics, Smuts resolves the challenge posed by race war by institutionalizing indirect rule and segregation as a project of pacification that ensured that settlement and the creative advance of the cosmos could proceed.