bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONDICIONAMENTO DO RELEVO AO LONGO DE ZONAS DE FALHA COM BANDAS DE DEFORMAÇÃO NA BACIA SEDIMENTAR RIO DO PEIXE, BRASIL
Authors: Barbosa Ana Beatriz da Silva , Maia Rúbson Pinheiro , Pontes Cayo César Cortez , Nogueira Francisco Cézar Costa , Bezerra Francisco Hilário Rêgo 
Published: April 2021

Este trabalho analisa o papel das zonas de falha com bandas de deformação na resistência ao intemperismo em rochas sedimentares, trazendo como estudo de caso a Bacia Sedimentar Rio do Peixe (BSRP), localizada no Nordeste do Brasil. Os dados foram obtidos por meio de sensoriamento remoto, trabalhos de campo, análises de resistência e topografia, extração de lineamentos e elaboração de modelos digitais de elevação, perfis topográficos e ortomosaicos de alta resolução. Observa-se que, em escala regional, há uma heterogênea distribuição das feições positivas de relevo, relacionadas com os sistemas de falhas de borda presentes na área (Portalegre e Malta), e estruturas deformando o arcabouço estrutural interno da bacia, sendo o trend NE-SW predominante tanto no embasamento quanto na BSRP. Os perfis topográficos mostraram que existe uma correlação entre os altos topográficos e as ocorrências de bandas de deformação (BDs). Elas estão presentes nas zonas de dano das falhas que afetam a bacia, onde se apresentam como enclaves de resistência ao intemperismo diferencial e modelam cristas estruturais. Esses relevos mais elevados correspondem à zona de dano interna e, com a diminuição da deformação, o acamamento sedimentar fica exposto. À medida que se afasta do núcleo da deformação, a topografia apresenta-se rebaixada e plana, favorecendo a presença de coberturas eluviais. Essas informações permitiram concluir que o relevo da BSRP, nos casos próximos das zonas de falha, apresenta condicionamento estrutural associado a episódios deformacionais que afetaram a permeabilidade e a resistência dos arenitos, levando, assim, à formação de cristas estruturais.
MODELAGEM HIDRODINÂMICA COMO FERRAMENTA DE APOIO À GESTÃO HÍDRICA DO RIO TAPAJÓS
Authors: Silva Eliézer Cláudio Ribeiro , Alves Fiamma Buchinger , Souza Marcelo José Raiol , Progênio Mayke Feitosa , Costa Carlos Eduardo Aguiar de Souza 
Published: April 2021

As crescentes demandas pelo uso da água têm agravado a quantidade e qualidade desse recurso vital à vida e, aliadas a eventos naturais extremos, podem intensificar a degradação dela. Diante disso, este estudo tem como objetivo analisar os eventos extremos máximos de vazões de um trecho do rio Tapajós, por meio da modelagem hidrodinâmica. Avaliou-se o potencial de utilização desta ferramenta inovadora dentro do processo de gestão e planejamento dos recursos hídricos. Para tal, lançou-se mão do modelo HEC-RAS, o qual representa um modelo hidrodinâmico unidimensional. O trecho estudado do rio Tapajós corresponde a aproximadamente 540 km e foram utilizadas quatro estações fluviométricas (Barra do São Manoel, Fortaleza, Acará do Tapajós e Itaituba) e suas respectivas séries históricas de cota e vazão, bem como o perfil transversal (batimetria) de cada estação. Os dados do perfil batimétrico foram acoplados com um Modelo Digital de Elevação (MDE) originado de dados SRTM, sendo estes os dados necessários para a simulação no HEC-RAS. As vazões foram extrapoladas para os Tempos de Retorno (TRs) de 10, 25, 50 e 100 anos, por meio da distribuição de frequência de Valor Extremo Generalizado (GEV), e as cotas foram calculadas pelo modelo hidrodinâmico. Na etapa de calibração, foi feito o ajuste do coeficiente de rugosidade Manning para as estações, os quais ficaram de 0,041 a 0,095. O coeficiente de determinação de Nash-Stucliffe ou R² foi maior que 0,99 em todas as estações. A simulação teve cotas simuladas entre 111,04 e 112,22 m (Barra do São Manuel), 82,87 e 83,29 m (Fortaleza), 60,56 e 61,07 m (Acará do Tapajós) e 19,75 e 20,15 m (Itaituba), sendo este último calculados pela GEV para a condição de contorno de jusante, considerando a variação de cota entre os TR100 e TR10. Os resultados desta modelagem são promissores dentro do campo da gestão hídrica, pois permitem a validação do modelo hidrodinâmico HEC-RAS para a simulação das alterações sofridas na bacia, consagrando-se como uma ferramenta de suma importância para a conservação dos recursos hídricos. Ressalta-se que os levantamentos periódicos de campo são indispensáveis, pois os modelos representam apenas uma aproximação da realidade do meio ambiente, sendo necessário alimentar o modelo com novos dados para minimizar as incertezas.
Wadai Production Activities for Warung Wadai 41 Sungai Tiung Village as a Learning Resource on Social Studies
Authors: Nazmi Nor , Subiyakto Bambang , Handy Muhammad Rezky Noor 
Published: April 2021

Perkembangan zaman mengakibatkan banyak perubahan pada kehidupan manusia, fenomena banyaknya generasi muda yang lebih menyukai makanan modern turut berpartisipasi menggeser kedudukan makanan tradisional, dikhawatirkan akan mengalahkan eksistensi dari Wadai 41, maka dari itu penting bagi dunia pendidikan khususnya seorang guru untuk mengajar sambil mengenalkan budaya daerah agar tidak punah dan tidak dilupakan sehingga dapat terus dilestarikan oleh penerus bangsa. Kegiatan ekonomi produksi untuk Warung Wadai 41 di kota Banjarbaru sejalan dengan konsep produksi dan keterkaitannya dengan materi IPS sehingga dapat dijadikan sumber belajar IPS. Artikel ini bertujuan untuk mendeskripsikan kegiatan produksi Wadai 41 di Kelurahan Sungai Tiung sumber belajar IPS. Pendekatan yang digunakan pada penelitian ini adalah pendekatan kualitatif dengan menggunakan metode deskriptif dan data didapatkan melalui observasi, wawancara, dan dokumentasi. Data yang telah didapat kemudian direduksi dan disajikan dalam bentuk narasi dilengkapi dengan gambar dan tabel relevansi materi sesuai dengan kompetensi dasar lalu kemudian ditarik kesimpulan. Keabsahan data melalui perpanjangan pengamatan, triangulasi sumber dan waktu. Pada artikel ini bahwa ada kegiatan produksi Wadai yang dilakukan oleh pemilik Warung Wadai 41 dengan menggunakan beberapa faktor seperti bahan baku, modal, dan tenaga kerja. Kegiatan mengolah beberapa jenis kue tradisional yang bernilai guna dikerjakan oleh tenaga kerja terampil mulai mengolah bahan mentah seperti mencampur tepung terigu dengan gula aren serta bahan-bahan lainnya, kemudian melakukan proses pematangan Wadai dengan alat tradisional hingga siap dipasarkan atau dijual di Warung Wadai 41, pada materi pelajaran IPS kelas VII semester genap tentang kegiatan ekonomi produksi sehingga penelitian ini dapat digunakan sebagai sumber belajar IPS.
THE CONCEPT OF PENAL MEDIATION FOR DEFAMATION DELICT IN THE INDONESIA ITE LAW AS A MANIFESTATION OF RESTORATIVE JUSTICE
Authors: Fajrin Yaris Adhial , Triwijaya Ach. Faisol 
Published: April 2021

<em>The paper aimed to analyze the position of defamation as a complaint delict in the ITE Law and the chances of applying penal mediation in the settlement of criminal defamation charges in the ITE Law. This research uses a normative legal research with qualitative analysis</em><em> techniques. The research result shows that defamation in the field of ITE is a complaint delict that the settlement of the case can be done through the Alternative Dispute Resolution (ADR) outside the court through penal mediation mechanism. The settlement of criminal cases through penal mediation has been in line with the direction of the renewal of Indonesian criminal law which is moving towards improving the impact of a criminal act as part of the purpose of criminalization. Penal mediation that promotes the values of consensus deliberation is also in line with the basic values of Pancasila, to encourage peace between the conflicting parties and improve the reputation, self-esteem, and dignity of victims damaged by defamation committed by the perpetrators. The advantages of penal mediation have not been followed by the rule of law of the event that regulates specifically the procedure of penal mediation so that not a few cases of defamation are ultimately decided by criminal sanctions to the perpetrators. Therefore, the mechanism of penal mediation needs to be regulated in the Indonesian Criminal Code in the future, to provide guarantees of a fair and beneficial criminal settlement for all parties, as well as a guarantee of the right to free responsible speech.</em>
The Impact of Corporate Culture on Marketing Performance
Authors: Fathoni Muhammad Anwar , Rodoni Ahmad 
Published: April 2021

<p align="center"><strong>ABSTRACT</strong></p><p align="center"> </p><p>The purpose of this study is to determine the typology of corporate culture of Islamic banking. This study also aims to determine the influence of corporate culture of Islamic banking on marketing performance.</p><p>This study proves that the corporate culture of Islamic banking that accommodates the Islamic teaching has influence on marketing performance.</p><p>This study is a comparative study between Bank Muamalat and BNI Syariah. Mixed method is used in this study to analyze collected data. The primary data obtained through survey and interview with employees of the Islamic bank. While secondary data obtained from the annual report documentation, books and articles in scientific journals and other sources that relevant to the research.</p><p><strong> </strong></p><p><strong>Keywords</strong>: Corporate Culture, Marketing Performance, Islamic Banking</p>
Body Mass Index Differentially Moderates Heritability of Total Joint Replacement Due to Hip and Knee Osteoarthritis
Authors: Hailer Nils P. , Kuja-Halkola Ralf , Brüggemann Anders , Pedersen Nancy L. , Michaëlsson Karl 
Published: April 2021

Background:
Osteoarthritis and obesity are diseases with high prevalence, and they share common etiologies. We investigated the sex-specific genetic susceptibility to hip and knee osteoarthritis necessitating total joint replacement (TJR), and how body mass index (BMI) moderated the heritability of these osteoarthritis phenotypes.

Methods:
We linked 29,893 twin pairs with information on BMI in the Swedish Twin Registry with the Swedish National Patient Register to identify twins who underwent primary TJR of the hip or knee combined with a concomitant diagnosis of primary osteoarthritis of these joints. Structural equation modeling was used to calculate the heritability of hip and knee osteoarthritis treated with TJR, with estimates adjusted for the first available BMI, birth year, and sex. We also investigated how heritability varied with BMI treated as a continuous variable.

Results:
Similar heritability estimates for hip replacement (0.65 [95% confidence interval (CI), 0.59 to 0.70]) and knee replacement (0.57 [95% CI, 0.50 to 0.64]) were found. Heritability decreased with higher BMI in both sexes for hip replacement and in men for knee replacement. In contrast, heritability for knee replacement increased with higher BMI in women; the estimate was 0.37 (90% likelihood interval [LI], 0.25 to 0.49) for a BMI of 20 kg/m2 and 0.87 (90% LI, 0.68 to 0.94) for a BMI of 35 kg/m2.

Conclusions:
In our population, heritability explained, on average, about half of the susceptibility to undergo primary TJR of the hip or knee with the indication of primary osteoarthritis, but it varied with BMI and sex. We demonstrated substantial heritability for knee replacement in obese women.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Children with Primary Septic Arthritis Have a Markedly Lower Risk of Adverse Outcomes Than Those with Contiguous Osteomyelitis
Authors: Hamilton Elizabeth C. , Villani Mary C. , Klosterman Mary M. , Jo Chanhee , Liu Jie , Copley Lawson A.B. 
Published: April 2021

Background:
It is widely believed that septic arthritis poses a risk of joint destruction and long-term adverse outcomes for children if not treated emergently. In the present study, children who had primary confirmed septic arthritis were compared with those who had septic arthritis and adjacent osteomyelitis to evaluate differences that affect the relative risk of adverse outcomes.

Methods:
Children who underwent multidisciplinary treatment for septic arthritis with or without contiguous osteomyelitis between 2009 and 2019 were retrospectively studied. Clinical, laboratory, treatment, and outcome data were compared between cohorts of children with primary confirmed septic arthritis and children with septic arthritis and contiguous osteomyelitis.

Results:
One hundred and thirty-four children had primary confirmed septic arthritis, and 105 children had septic arthritis with contiguous osteomyelitis. Children with osteomyelitis were older (median, 7.4 versus 2.4 years), had higher initial C-reactive protein (median, 15.7 versus 6.4 mg/dL), and had a higher rate of thrombocytopenia (21.0% versus 1.5%). They also had a higher rate of bacteremia (69.5% versus 20.2%) for a longer duration (median, 2.0 versus 1.0 days). Detected pathogens in children with osteomyelitis as compared with those with primary septic arthritis were more likely to be Staphylococcus aureus (77.1% versus 32.1%) and less likely to be Kingella kingae (2.9% versus 32.1%). Children with contiguous osteomyelitis had longer hospitalizations (median, 8.0 versus 4.0 days), a higher rate of intensive care (21.0% versus 1.5%), a higher readmission rate (17.1% versus 5.2%), and a higher complication rate (38.1% versus 0.7%).

Conclusions:
Primary septic arthritis in children is dissimilar to septic arthritis associated with osteomyelitis. The present study demonstrates that long-term adverse outcomes in children with septic arthritis are likely due to the contiguous osteomyelitis. Children with primary septic arthritis are sufficiently distinguishable from those who have contiguous osteomyelitis to guide decisions for magnetic resonance imaging acquisition, duration of antibiotic therapy, and length of outpatient follow-up in order to recognize and address adverse outcomes.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Patient Age and Cell Concentration Influence Prevalence and Concentration of Progenitors in Bone Marrow Aspirates
Authors: Mantripragada Venkata P. , Boehm Cynthia , Bova Wesley , Briskin Isaac , Piuzzi Nicolas S. , Muschler George F. 
Published: April 2021

Background:
Connective tissue progenitors (CTPs) resident in native tissues serve as biological building blocks in tissue repair and remodeling processes. Methods for analysis and reporting on CTP quantity and quality are essential for defining optimal cell sources and donor characteristics and the impact of cell processing methods for cell therapy applications. The present study examines the influence of donor characteristics and cell concentration (nucleated cells/mL) on CTP prevalence (CTPs/million nucleated cells) and CTP concentration (CTPs/mL) in bone marrow aspirates (BMAs).

Methods:
Iliac crest bone marrow was aspirated from 436 patients during elective total knee or hip arthroplasty. Bone marrow-derived nucleated cells were plated at a density of 1.19 × 105 cells/cm2. Colony-forming unit analysis was performed on day 6.

Results:
Large variation was seen between donors. Age (p < 0.05) and cell concentration (p < 0.001) significantly influenced CTP prevalence and CTP concentration. For every 1-year increase in age, the odds of having at least an average CTP prevalence and CTP concentration decreased by 1.5% and 1.6%, respectively. For every 1 million cells/mL increase in cell concentration, the odds of having at least an average CTP prevalence and CTP concentration increased by 2.2% and 7.9%, respectively. Sex, race, body mass index (BMI), and the presence of osteoporosis did not influence CTP prevalence or CTP concentration.

Conclusions:
BMA-derived CTPs were obtained from all patient groups. CTP prevalence and CTP concentration decreased with age. Cell concentration decreased with age and positively correlated with total CTP prevalence and CTP concentration. The mean CTP concentration in patients >60 years of age was a third of the CTP concentration in patients <30 years of age.

Clinical Relevance:
Proper BMA techniques are necessary to obtain a high-quality yield and composition of cells and CTPs. The reduced CTP concentration and CTP prevalence in the elderly may be mitigated by the use of cell processing methods that increase CTP concentration and CTP prevalence (e.g., by removing red blood cells, serum, and non-CTPs or by increasing aspirate volumes). Cell concentration in the BMA can be measured at the point of care and is an appropriate initial assessment of the quality of BMA.
Transitions of Wear Characteristics for Rubber/Steel Seal&nbsp;&nbsp;Pairs During the Abrasive Wear Process
Authors: Zhou Qin , Li Shuaishuai , Zhang Kai , Qin Kun , Lv Minghao , Sun Weihao , Yuan Tongxin 
Published: April 2021

Abstract
Abrasive wear resulting from the microclastic rock is a common failure phenomenon in the drilling environmentthat often limits the sealing ability and the service life of seals. In this study, the friction and wear process of fluoro rubber (FKM) seals against 304 stainless steel (SS304) after one single entry of SiO2 abrasives were investigated. The influence of the changes in particle state on friction coefficient evolution, wear loss evolution, wear morphologies and wear mechanisms were discussed in detail. The results indicate that the presence of abrasive particles dispersed between the sealing interface clearly improves the friction performance of the seal pairs and deteriorates the wear performance of the metal counterpart. The movement and breakage of particles after one single entering into the sealing interface were obtained. And on this basis, the stable wear process can be divided into three stages. In addition, the main causes contributed to this change of wear mechanisms are the random movement and process of continuous breakdown of abrasive particles. Furthermore, the transition of the wear mechanism that clearly describes the wearing behavior of the seal pairs under these abrasive wear conditions was identified. The results of this study enhanced our understanding of the abrasive wear degradation of rubber seal in practical drilling applications.
Assessment of Interface Trap Charges on Proposed TFET for Low Power High-frequency Application
Authors: Kumar Sachin , Yadav Dharmendra Singh 
Published: April 2021

Abstract
Accumulation of trap charges at the semiconductor and oxide interface is the most dominating factor and cannot be neglected as it degrades device performance and reliability. This manuscript, presents detailed investigation to analyze the impact of interface trap charges (ITCs) on the performance parameters of the proposed device i.e., heterogeneous dielectric dual metal gate step channel TFET (HD DMG SC-TFET). The comparative study is conducted with dual metal gate step channel TEFT (DMG SC-TFET). The proposed device shows improved current carrying capability, suppressed ambipolar behaviour with steeper subthreshold swing. The purpose of this study to determine the ITCs impact on DC characteristics and analog/RF electrical performance parameters of the proposed device. It further observed that the proposed device exhibit superior performance due to dielectric engineering at oxide layer. Moreover, advanced communication devices must respond linearly therefore, the impact of ITCs on linearity parameters is also studied. From this brief comparative investigation, it is observed that the proposed TFET exhibits negligible distortion in linearity parameters with little or no impact of trap charges as compared to DMG SC-TFET. Thus, proposed TFET is appropriate for ultra-low power high-frequency electronic devices.
Integrative Network Analysis of Early-Stage Lung Adenocarcinoma Identifies Aurora Kinase Inhibition as Interceptor of Invasion and Progression
Authors: Yoo Seungyeul , Sinha Abhilasha , Yang Dawei , Altorki Nasser , Tandon Radhika , Wang Wenhui , Chavez Deebly , Lee Eunjee , Patel Ayushi , Sato Takashi , Kong Ranran , Ding Bisen , Schadt Eric , Watanabe Hideo , Massion Pierre , Borczuk Alain , Zhu Jun , Powell Charles 
Published: April 2021

Abstract
We present a gene signature distinguishing invasive and indolent tumors among early-stage lung adenocarcinoma (esLUAD). An Invasiveness Score estimated using the gene signature was strongly associated with survival of esLUAD patients in multiple independent cohorts and with the invasiveness phenotype in lung cancer cell lines. Regulatory network analysis identified aurora kinase as one of master regulators of the gene signature and perturbation of aurora kinases in vitro and in vivo reduced tumor invasion. Our study suggests aurora kinases as a novel target for treating early-stage invasive lung adenocarcinoma.
Pre-exposure prophylaxis with hydroxychloroquine for COVID-19: initial results of a double-blind, placebo-controlled randomized clinical trial
Authors: Grau-Pujol Berta , Camprubí Daniel , Marti-Soler Helena , Fernández-Pardos Marc , Carreras-Abad Clara , Andrés Maria Velasco de , Ferrer Elisabet , Muelas-Fernandez Magdalena , Jullien Sophie , Barilaro Giuseppe , Ajanovic Sara , Vera Isabel , Moreno Laura , Gonzalez-Redondo Eva , Cortes-Serra Núria , Roldán Montserrat , Arcos Ana Artes de , Mur Isabel , Domingo Pere , Garcia Felipe , Guinovart Caterina , Muñoz Jose 
Published: April 2021

Abstract
Background: Pre-exposure prophylaxis (PrEP) is a promising strategy to break COVID-19 transmission. Although hydroxychloroquine was evaluated for treatment and post-exposure prophylaxis, it is not evaluated for COVID-19 PrEP yet. The aim of this study was to evaluate efficacy and safety of PrEP with hydroxychloroquine against placebo in healthcare workers at high risk of SARS-CoV-2 infection during an epidemic period.Methods: We conducted a double-blind placebo-controlled randomized clinical trial in three hospitals in Barcelona, Spain. From 350 adult healthcare workers screened, we included 269 participants with no active or past SARS-CoV-2 infection (determined by a negative nasopharyngeal SARS-CoV-2 PCR and a negative serology against SARS-CoV-2). Participants allocated in the intervention arm (PrEP) received 400mg of hydroxychloroquine daily the first four consecutive days and subsequently, 400mg weekly during the study period. Participants in the control group followed the same treatment schedule with placebo tablets. Results: 52.8% (142/269) of participants were in the hydroxychloroquine arm and 47.2% (127/269) in the placebo arm. Both groups showed similar proportion of participants experiencing at least one adverse event (AE) (p=0.548). No serious AEs were reported. Almost all AEs (96.4%, 106/110) were mild. Only mild gastrointestinal symptoms were significantly higher in the hydroxychloroquine arm compared to the placebo arm (27.4% (39/142) vs 15.7% (20/127), p=0.041). Given the national epidemic incidence decay, only one participant in each group was COVID-19 diagnosed. Consequently, our study design deemed underpowered to evaluate any benefit regarding PrEP efficacy.Conclusions: First month follow-up analysis displayed that PrEP with hydroxychloroquine at low doses is safe.Trial registration: This trial was registered at clinicaltrials.gov (NCT04331834) on April 2nd 2020. https://clinicaltrials.gov/ct2/show/NCT04331834?term=NCT04331834&draw=2&rank=1