bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravenous Albumin for the Prevention of Hemodynamic Instability During Sustained Low-Efficiency Dialysis. A Randomized Controlled Feasibility Trial. (The SAFER-SLED Study)
Authors: Clark Edward , McIntyre Lauralyn , Watpool Irene , Kong Jennifer WY. , Ramsay Tim , Sabri Elham , Canney Mark , Hundemer Gregory L. , Brown Pierre-Antoine , Sood Manish M. , Hiremath Swapnil 
Published: July 2021

Abstract
Background: Hemodynamic instability is a frequent complication of sustained low-efficiency dialysis (SLED) treatments in the ICU. Intravenous hyperoncotic albumin may prevent hypotension and facilitate ultrafiltration. In this feasibility trial, we sought to determine if a future trial, powered to evaluate clinically relevant outcomes, is feasible. Methods: This single-centre, blinded, placebo-controlled, randomized feasibility trial included patients with acute kidney injury who started SLED in the ICU. Patients were randomized to receive 25% albumin versus 0.9% saline (control) as 100 mL boluses at the start and midway through SLED, for up to 10 sessions. The recruitment rate and other feasibility outcomes were determined. Secondary exploratory outcomes included ultrafiltration volumes and metrics of hemodynamic instability.Results: Sixty patients (271 SLED sessions) were recruited over 10 months. Age and severity of illness were similar between study groups. Most had septic shock and required vasopressor support at baseline. Protocol adherence occurred for 244 sessions (90%); no patients were lost to follow-up; no study-related adverse events were observed; open label albumin use was 9% and 15% in the albumin and saline arms, respectively. Ultrafiltration volumes were not significantly different but, compared to the saline group, the albumin group experienced less hemodynamic instability across all definitions assessed including a smaller absolute decrease in systolic blood pressure (mean difference 10.0 mmHg, 95% confidence interval 5.2 - 14.8).Conclusions: SLED patients who received intravenous 25% albumin during treatments experienced less hemodynamic instability than those who received 0.9% saline. A larger trial to evaluate clinically relevant outcomes is feasible.Trial Registration: ClinicalTrials.gov (NCT03665311); First Posted: Sept 11th, 2018. https://clinicaltrials.gov/ct2/show/NCT03665311?term=NCT03665311&draw=2&rank=1
A rare case of recurrent ovarian cancer with NTRK1-TPM3 gene rearrangement
Authors: Endo Yuta , Watanabe Takafumi , Saito Motonobu , Saito Katsuharu , Suzuki Rei , Sano Hideki , Natori Yutaka , Sasaki Eisaku , Ueda Makiko , Kamo Norihito , Furukawa Shigenori , Soeda Shu , Kono Koji , Saji Shigehira , Fujimori Keiya 
Published: July 2021

Abstract
Background: NTRK gene fusion is rare in gynecologic cancer. Entrectinib is a novel targeted drug which is a potent inhibitor of TRK A, B and C. Here, we present a case of recurrent ovarian cancer with NTRK1-TPM3 rearrangement, which was detected by next-generation sequencing (NGS) and treated with entrectinib. Case Presentation:A 56-year-old woman was diagnosed as having stage IV ovarian cancer due to pleural effusion. Neoadjuvant chemotherapy and interval debulking surgery followed by chemotherapy were performed. Ten months after completion of chemotherapy, the patient’s disease recurred. She was treated with multimodal therapy for recurrence. DNA-based NGS detected NTRK1-TPM3 rearrangement and entrectinib was started. However, the patient’s disease progressed despite six weeks’ administration of entrectinib, and one month after discontinuation of entrectinib, she died. After her death immunohistochemistry with a pan-Trk monoclonal antibody was performed to determine the expression of NTRK. However, immunohistochemistry was negative for NTRK.Conclusion: We presented a rare case of recurrent ovarian cancer with NTRK1-TPM3 gene fusion, in which entrectinib was not effective. While NTRK gene fusion was detected by DNA-based NGS, immunohistochemistry was negative for NTRK. Immunohistchemitory should be performed for confirmation of NTRK protein expression before entrectinib administration.
A qualitative evaluation of a 'covid responder' scheme for medical students
Authors: Grafton-Clarke Ciaran , Uraiby Hussein , Abraham Shalin , Ramjee Ayushi , Kent Jennifer , Parnham Rosie , Kirtley Joanne , McCarthy Mark 
Published: July 2021

Abstract
Background

The first UK wave of COVID-19 led to the temporary suspension of medical school placements. Medical students were offered paid employment through a COVID Responder Scheme (CRS). We aimed to qualitatively assess the experience of those who participated in this scheme in comparison to traditional clinical attachments.
Summary of work

A bespoke questionnaire was designed to explore key themes identified through theme selection, literature review and consensus. Following piloting and validation, the questionnaire was circulated to students recruited to the CRS. A grounded theory analytic framework was used to analyse data. A modified-Delphi consensus process was used to reach a consensus on ‘what makes you feel most valued as a medical student’.
Summary of results

36 students (46.2% response rate) responded. 86.1% of respondents felt their contribution was worthwhile. 65% reported being significantly more integrated into a team than in their university attachments. Concerns prior to starting CRS work included availability of PPE and the ability to contribute effectively, but refreshingly these concerns did not present as challenges. The steep learning curve of experiential learning alongside virtual teaching commitments proved difficult to juggle when facing physical, mental and emotional fatigue from long hours working busy clinical shifts. Respondents cited the educational benefit of the CRS throughout the survey. Recognition and commendation were highly effective in providing a sense of value ahead of renumeration. 44.4% of respondents were concerned about their future training and a reduction in clinical exposure.
Discussion

The majority of respondents reported CRS work as worthwhile, with reasons including increased responsibility for patient care and a sense of contribution to the clinical team. This in turn led to autonomous practice and task accountability, which further integrated them into the team and developed their clinical confidence. A student’s sense of value was strongly linked to being identified in emotional responses from colleagues and patients ahead of financial renumeration, suggesting scope for improvement within unpaid attachments / rotations.
Conclusion

There is an opportunity to take value from the COVID-19 medical student experience to improve undergraduate medical education through and beyond the pandemic.
Social network-based ethical analysis of COVID-19 vaccine supply policy in three Central Asian countries
Authors: Aripov Timur , Wikler Daniel , Asadov Damin , Tulekov Zhangir , Murzabekova Totugul , Munir Kerim 
Published: July 2021

Abstract
Abstract
Background
In the pandemic time, many low- and middle-income countries are experiencing restricted access to COVID-19 vaccines. An access to imported vaccines or ways to produce them locally becomes the principal source of hope. But developing a strategy for success in obtaining and allocating vaccines is not easy task. The governments in those countries have faced difficult decision whether to accept or reject offers of vaccine diplomacy, weighing price and availability of COVID-19 vaccines against concerns over their efficacy and safety. Our aim was to analyze public opinion regarding the governmental strategies to obtain COVID-19 vaccines in three Central Asian countries, focusing particularly on possible ethical issues.
Methods
We searched opinions expressed either in Russian or in the respective national languages. We provided data of the debate within three countries, drawn from social media postings and other sources. The opinion data was not restricted by source and time. This allowed to collect a wide range of possible opinions that could be expressed regarding COVID-19 vaccine supply and public’s participation in vaccine trials. We recognized ethical issues and possible questions concerning different ethical frameworks. We also considered additional information or scientific data, in the process of reasoning.
Results
As a result, public views on their respective government policies on COVID-19 vaccine supply ranged from strongly negative to slightly positive. We extracted most important issues from public debates, for our analysis. The first issue involved trade-offs between quantity, speed, price, freedom, efficacy and safety in the vaccines. The second set of issues arouse in connection with the request to site a randomized trial in one of countries (Uzbekistan). After considering additional evidences, we weighed individual with public risks and benefits to make specific judgements concerning every issue.
Conclusions
We believe that our analysis would be a helpful example of solving ethical issues that can rise concerning COVID-19 vaccine supply round the world. The public view can be highly critical, helping to spot such issues. An ignoring this view can lead to major problems, which in turn, can become a serious obstacle for the vaccine coverage and epidemics’ control in the countries and regions.
Transmission of Gastrointestinal Parasites in between Deer and Livestock Species at buffer zone located within the eastern part of Chitwan National Park, Nepal
Authors: Sapkota Subash , Regmi Sagar , Ghimire Roshan , Pokhrel Ashish , Sadaula Amir , Shrestha Bijaya Kumar 
Published: July 2021

Abstract
Deer are the hoofed ruminants of the order Artiodactyla and suborder Ruminantia in which infectious disease and parasites are of major concern in their conservation. This specific research helps us to determine the transmission of gastrointestinal parasites between deer and livestock in the buffer zone. The study was conducted in the eastern part of Chitwan National Park from June 2020 to July 2020. Fecal examination for the parasitic load was carried out using Floatation and Sedimentation techniques. 96.49% of the total fecal samples tested for parasitic eggs were found to be positive for the prevalence of gastro-intestinal parasite whereas parasitic prevalence in livestock of Buffer Zone i.e. Sauraha and Bachhauli area was calculated to be 87.30% based on the examination conducted within that same period and same area by the veterinary hospital. Pramphistomum was the most prevalent one in both deer (72.72%) and livestock (52.63%). The finding of this research revealed the higher chances of the exchange of parasites between the deer and livestock. A more advanced study must be done in this sector and concerned authorities should develop and implement effective plans to prevent cross-transmission of parasites between deer and livestock and other wildlife.
High burden of hypovitaminosis D among the children and adolescents in South Asia: A systematic review and meta-analysis
Authors: Siddiqee Mahbubul Hasan , Bhattacharjee Badhan , Siddiqi Umme Ruman , Rahman Mohammad Meshbahur 
Published: July 2021

Abstract
Background: Vitamin D is vital for the growth and development of children. While deficiency and/or insufficiency of vitamin D among South Asian children are frequently reported in the literature, the lack of a meta-analysis has left its true extent poorly characterized. In this study, we aimed to conduct a systematic review and perform meta-analyses of the prevalence of hypovitaminosis D among the children of the South Asian countries.Methods: Two major electronic search engines (PubMed and Scopus) and one database (Google scholar) were used; original studies, conducted among South Asian children and adolescents and published between 1st January 2001 and 31st December 2019. A random-effect meta-analysis was also performed to calculate the pooled prevalence of hypovitaminosis D followed by subgroup analyses for countries and age-groups.Results: After applying inclusion and exclusion criteria, a total of 41 studies with a total population size of 18,233 were finally selected. The overall prevalence of hypovitaminosis D was 61% [95% CI: 46% to 71%] with highly significant heterogeneity (I2 = 99.72%; p = 0.00). The average level of serum vitamin D ranged from 5 ng/mL to 34 ng/mL, with a weighted mean of 19.15 ng/mL (weighted standard deviation 11.59 ng/mL). Country-wise analysis showed that hypovitaminosis D in Afghanistan was the highest [96.2%; 95% CI: 91% to 99%], followed by Pakistan [94%; 95% CI: 90% to 96%], India [64%; 95% CI: 46% to 79%], Bangladesh [35.48%; 95% CI: 32% to 39%], Nepal [35%; 95% CI: 1% to 83%.]and Sri Lanka [25%; 95% CI: 16% to 36%]. Age-group analyses revealed that hypovitaminosis D was most prevalent among neonates [85%; 95% CI: 76% to 91%], followed by school-going children [57%; 95% CI: 33% to 80%], and pre-school children [55%; 95% CI: 35% to 75%].Conclusion: This study generates quantitative evidence and specific extent of hypovitaminosis D in the South Asian countries as a public health concern. Being the first systematic review for this region, results from this study will create awareness and will facilitate adopting mitigation strategies by the policymakers and the governments to address this problem.
Exon Skipping as a Therapeutic for Neurofibromatosis Type I
Authors: Wallis Deeann , Leier Andre , Moore Marc , Daniel Michael , Liu Hui , Hyde Alexis , Messiaen Ludwine , korf Bruce , Selvakumaran Jamuna , Ciszewski Lukasz , Lambert Laura , Foote Jeremy , Kesterson Robert , Dickson George , Popplewell Linda 
Published: July 2021

Abstract
We investigated the feasibility of utilizing an exon skipping approach as a genotype-dependent therapeutic for neurofibromatosis type 1 (NF1) by determining which NF1 exons might be skipped while maintaining neurofibromin function. Human neurofibromin is well-known as a GTPase activating protein (GAP), but outside of its GAP-related domain (GRD), it is unclear how critical other regions are for function. Initial in silico analysis predicted exons that can be skipped with minimal loss of neurofibromin function. Utilizing a novel Nf1 cDNA system, we performed a functional screen to determine the effects of exon skipping on in vitro neurofibromin expression and GRD function. Loss of single exons 12, 17, 25, 41, 47, or 52 maintained significant GRD function in at least two Ras activity assays. Exons 18/19, 20 and 28 are critical for GRD function; deletion of exons 20, 41, or 47 led to significantly lower levels of neurofibromin. As suggested by in silico analysis, skipping of exons 17 or 52 resulted in both the highest neurofibromin levels and the greatest suppression of Ras activity. Assessment of NF1 patient databases indicates that pathogenic variants resulting in deletion or skipping of exons 17, 25, and 52 have not been reported; and truncating pathogenic variants in each exon account for ~0.91, 0.94, and 0.25% of unrelated NF1 cases, respectively. Hence, we designed antisense phosphodiamitate morpholino oligos (PMOs) to skip exon 17 and evaluated them in human cell lines that we generated via CRISPR/Cas9 with a patient-specific truncating pathogenic variant, c.1885G>A. We down-selected oligos that efficiently caused skipping of exon 17 and restored NF1 expression and function. Further, homozygous deletion of exon 17 in a novel mouse model is compatible with viable and grossly healthy animals with normal lifespan and no tumor development, providing proof-of-concept that exon 17 is not essential for murine neurofibromin function. Mild phenotypes observed include abnormal nesting behavior and lymphoid hyperplasia with increased numbers of both B- and T-cells. Hence, exon skipping should be further investigated as a therapeutic approach for NF1 patients with treatment of individuals with pathogenic variants in exon 17.
Innovation of Herbal Tourism Village Concepts as Alternative for Tourism in the Post-Pandemic New Normal Era
Authors: Utama I Gusti Bagus Rai , Erfiani Ni Made Diana , Wuruwu Dermawan , Susanto Putu Chris , Turker Sidhi Bayu , Suyasa Ni Luh Christine Prawitha , Darmawijaya I Putu , Trimurti Christimulia Purnama 
Published: July 2021

Abstract
The novelty of this paper is the application of downstream innovation in the tourism concept into herbal tourism village as alternative form of tourism in the post-pandemic new normal era. It is based on a project as an implementation of previous research results related to tourism villages, in particular Catur Tourism Village, Kintamani, Bali. The results of the project can strengthen community-based tourism initiatives in Catur Tourism Village by strengthening homestay management so that the attraction of overnight tourism increases following the standards of hospitality, cleanliness, health, safety, and environmental sustainability in the adaptation to new and post-pandemic habits. Designing and marketing the potentials for natural, agro, herbal, and cultural tourism were done through co-development in exploring, packaging, and presenting tourist attractions as something to see. Empowering and instilling the values ​​of excellent service quality local tour guides in eco-tourism exploration as something to do. Empowering tourism village managers and villagers in developing tourism products based on the principles of Sapta Pesona, including developing and packaging Catur Village souvenir products as something to buy, so that tourists get a thorough tourism experience.
Моделирование спектров люминесценции в сферических микрорезонаторах с излучающей оболочкой
Authors: Дукин А.А. , Голубев В.Г. 
Published: July 2021

The luminescence spectra of a microresonator structure consisting of a spherical core of small diameter (3.5 – 6 mcm) covered with a luminescent shell with a refractive index less than that of the core are modeled. Shell luminescence spectra, radial distribution of the whispering gallery mode (WGM) field, and mode parameters (wavelength, width, quality factor) are calculated using the expansion of the electromagnetic wave field in the basis of vector spherical harmonics and the method of spherical wave transfer matrices. The dependence of the luminescence spectra and WGM parameters on the geometric and optical parameters of the structure - the shell thickness, the refractive index of the shell, and the core diameter - is studied.
Penggunaan Pelarut Etanol dan Aseton pada Prosedur Kerja Ekstraksi Total Klorofil Daun Jati (Tectona grandis) dengan Metode Spektrofotometri
Authors: Sumiati Sumiati 
Published: July 2021

Penelitian ini bertujuan untuk mengetahui kadar total klorofil pada daun jati yang diekstraksi menggunakan pelarut etanol dan aseton, dan untuk mengetahui perbedaan kadar total klorofil pada daun jati yang diekstraksi menggunakan pelarut etanol dan aseton. Berdasarkan hasil analisis kadar klorofil pada ekstraksi daun jati menggunakan metode Spektrofotometri pada pelarut etanol diperoleh hasil kadar klorofil a adalah 31,437 mg/L dan klorofil b sebesar 27,468 mg/L, sedangkan untuk pelarut aseton diperoleh hasil kadar klorofil a adalah 35,279 mg/L dan klorofil b sebesar 27,640 mg/L. Kadar total klorofil pada daun jati dengan pelarut etanol diperoleh hasil sebesar = 59,138 mg/L, dan untuk pelarut aseton diperoleh hasil 62,900 mg/L.
Safety and Efficacy for the Combination of Alpha Lipoic Acid, Gingko Biloba, Vitamin C, Zinc, Magnesium, Vitamin B6, Methylcobalamin, Vitamin E and Chromium Picolinate for the Medical Management of Age Related Hearing Loss: Post Marketing Surveillance Study
Authors: Kiran Dr. Mayuresh , Pawaskar Mr. Lalit , Sheikh Ms. Shaheen , Waghambare Ms. Pramita 
Published: July 2021

Introduction: Age related hearing loss is defined as a bilateral, progressive, symmetrical age-related sensorineural hearing loss, which is most pronounced at the higher frequencies. It is considered that oxidative stress has a central role in the pathology of age-related hearing loss so, this study was conducted to test the efficacy and safety for the combination of antioxidants for the treatment of age-related hearing loss. Methodology: This was a multi-centric study conducted at 11 clinical trial sites. Out of total 176 enrolled, 160 trial subjects completed the study. For efficacy assessment, 2 parameters were used including hearing related quality of life score and score obtained from hearing impairment questionnaire on day 0 (visit 1), 45 (visit 2) and 90 (visit 3). Results: At visit 1, the mean hearing related quality of life score was 4.437 increased to 5.725 at visit 2 and further increased to 6.906 at visit 3. At visit 2 and 3, the increase in hearing related quality of life score was 29.028% and 55.645% respectively as compared to baseline. The score obtained from hearing impairment questionnaire was 25.581 at visit 1 reduced to 16.200 and further reduced to 9.943 at visit 3. Conclusion: The combination of Alpha lipoic acid, Gingko biloba, Vitamin C, Zinc, Magnesium, Vitamin B6, Methyl cobalamin, Vitamin E and Chromium Picolinate can be used for the medical management of age related hearing loss.
КНИЖКА ПРО ВАЖКІ ПРОБЛЕМИ
Authors: Левицький Мирослав 
Published: July 2021

Рецензія на книгу:
Чобіт Д. Загибель Гути Пеняцької 28 лютого 1944 року. Київ : Видавничий дім «Українська культура», 2020. Кн. 1 : Трагедія. 612 с.
БІОІСТОРІОГРАФІЯ УЧАСТІ ЖІНОК В УКРАЇНСЬКОМУ ВИЗВОЛЬНОМУ РУСІ 1920–1950-х рр.
Authors: Капустинський Назарій 
Published: July 2021

Анотація. Мета дослідження – проаналізувати історіографічні джерела, в яких міститься інформація про участь та діяльність жінок в національно-визвольному русі 30–50-х рр. ХХ ст. і з’ясувати ступінь дослідженості проблеми, виокремити маловивчені або й взагалі невивчені аспекти. Методологія дослідження спирається на принципи історизму, системності, об’єктивності, поміркованого наративного конструктивізму, а також на використання загальнонаукових (аналіз, синтез, узагальнення) та спеціально-історичних (історико-генетичний, історико-типологічний, історико-системний) методів. Наукова новизна полягає у тому, що вперше зроблено спробу зібрати, систематизувати й охарактеризувати історико-біографічні праці про участь і роль жінок в національно-визвольному русі 1930–1950-х рр., окреслити коло недостатньо вивчених питань і перспективні напрями подальших наукових пошуків. Висновки. Отже, активізація появи нових біографічних досліджень про участь жінок в українському визвольному русі 1920–1950-х рр. стала можливою тільки після здобуття Україною незалежності. Так вдалося повернути із забуття імена сотень та навіть тисяч учасниць ОУН і УПА. Однак біографічні студії участі жіноцтва в національно-визвольних змаганнях перебувають на початковому етапі. Попри те, що в останні роки з’являються праці, в яких порушуються різноманітні проблеми участі жінок в українському визвольному русі, значна кількість потребує ще подальшого вивчення. І тут досить різка відмінність із біографічними дослідженнями участі чоловіків у цих структурах. Украй необхідним на сьогоднішній день вбачаємо продовження ґрунтовної пошукової роботи. Суттєвим недоліком є практично відсутність жіночих біографічних студій на дисертаційному рівні. Немає і окремих досліджень на монографічному рівні (за винятком праці про Катерину Зарицьку). Особливо цей пробіл відчувається щодо діяльності жінок на кущовому, районному, надрайонному, окружному, обласному та крайовому рівнях, у відділах і підвідділах УПА.