bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective multicentre randomised clinical trial comparing survival rates, quality of life and nutritional status between advanced gastric cancer patients with different follow-up intensities: study protocol for the STOFOLUP trial
Authors: Eom Bang Wool , Koo Dong-Hoe , An Ji Yeong , Lee Han Hong , Kim Hyoung-Il , Hur Hoon , Yoo Moon-Won , Ryu Min-Hee , Lee Hyuk-Joon , Kim Su Mi , Park Ji-Ho , Min Jae Seok , Seo Kyung Won , Jeong Sang-Ho , Jeong Oh , Kwon Oh Kyoung , Ryu Seung Wan , Yoo Chang Hak , Bae Jae Moon , Ryu Keun Won 
Published: December 2021

IntroductionPatients who underwent curative gastrectomy for gastric cancer are regularly followed-up for the early detection of recurrence and postoperative symptom management. However, there is a lack of evidence with regard to proper surveillance intervals and diagnostic tools. This study aims to evaluate whether frequent surveillance tests have a survival benefit or improve the quality of life in patients who underwent curative resection for advanced gastric cancer.Methods and analysisThe STOFOLUP trial is an investigator-initiated, parallel-assigned, multicentre randomised controlled trial involving 16 hospitals in the Republic of Korea. Patients (n=886) diagnosed with pathological stage II or III gastric adenocarcinoma will be randomised to either the 3-month or the 6-month group at a 1:1 ratio, stratified by trial site and tumour stage. Patients allocated to the 3-month group will undergo an abdominal CT scan every 3 months postoperatively and those allocated to the 6-month group will undergo CT every 6 months. The primary endpoint is 3-year overall survival and the secondary endpoints are quality of life, as assessed using KOrean QUality of life in Stomach cancer patients Study group-40, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and the stomach cancer-specific module (STO22), and nutritional outcomes. Other survival data including data concerning 3-year disease-free survival, recurrence-free survival, gastric cancer-specific survival and postrecurrence survival will also be estimated. The first patient was enrolled on July 2021 and active patient enrolment is currently underway.Ethics and disseminationThis study has been approved by the Institutional Review Board of eight of the participating hospitals (NCC 2021-0085, KBSMC2021-01-059, SMC 2021-01-140, KC21OEDE0082, 4-2021-0281, AJIRB-MED-INT-20-608, 2021-0515 and H-2102-093-1198). This study will be disseminated through peer-reviewed publications, national or international conferences.Trial registration numberNCT04740346.
Coping in patients with pancreatic cancer: a scoping review and narrative synthesis
Authors: Ristau Patrick , Oetting-Roß Claudia , Büscher Andreas 
Published: December 2021

IntroductionPancreatic cancer is a malignant disease with one of the highest cancer-specific mortality rates. Coping with it probably differs from other malignant diseases. This scoping review was intended to explore and characterise academic literature related to the coping in patients with pancreatic cancer.MethodsEight databases were searched for primary and secondary studies and reviews reporting on coping with pancreatic cancer (adenocarcinoma) in adults in English or German language, regardless of publication date or study design, which were then analysed and summarised by narrative synthesis.ResultsOf 1472 publications identified, 9 articles and book contributions published from 1989 to 2020 in the USA, Europe and Australia met the inclusion criteria. The two main aspects covered were the confrontation with coping tasks, and the reciprocally associated coping with these challenges. In particular, the coping tasks revealed some pancreatic cancer-specific features, such as an increased incidence of depression and anxiety or certain digestive problems, whereas applying of coping strategies seems to be more like the coping behaviours known from the literature for other severe or cancer diseases.ConclusionsPatients with pancreatic cancer experience various health issues and face various quality of life changes and coping tasks. Disease-specific contextual factors, usually consisting of late diagnosis at an advanced stage, rapid progression and often poor prognosis, as well as disease-specific challenges are major differences compared with other malignancies or serious illnesses. However, the coping strategies applied do not seem to differ in principle. Currently, no pancreatic cancer-specific coping model exists.
Occupational risk of SARS-CoV-2 infection and reinfection during the second pandemic surge: a cohort study
Authors: Leidi Antonio , Berner Amandine , Dumont Roxane , Dubos Richard , Koegler Flora , Piumatti Giovanni , Vuilleumier Nicolas , Kaiser Laurent , Balavoine Jean-François , Trono Didier , Pittet Didier , Chappuis François , Kherad Omar , Courvoisier Delphine Sophie , Azman Andrew S , Zaballa Maria Eugenia , Guessous Idris , Stringhini Silvia 
Published: December 2021

ObjectivesThis cohort study including essential workers, assessed the risk and incidence of SARS-CoV-2 infection during the second surge of COVID-19 according to baseline serostatus and occupational sector.MethodsEssential workers were selected from a seroprevalence survey cohort in Geneva, Switzerland and were linked to a state centralised registry compiling SARS-CoV-2 infections. Primary outcome was the incidence of virologically confirmed infections from serological assessment (between May and September 2020) to 25 January 2021, according to baseline antibody status and stratified by three predefined occupational groups (occupations requiring sustained physical proximity, involving brief regular contact or others).Results10 457 essential workers were included (occupations requiring sustained physical proximity accounted for 3057 individuals, those involving regular brief contact, 3645 and 3755 workers were classified under ‘Other essential occupations’). After a follow-up period of over 27 weeks, 5 (0.6%) seropositive and 830 (8.5%) seronegative individuals had a positive SARS-CoV-2 test, with an incidence rate of 0.2 (95% CI 0.1 to 0.6) and 3.2 (95% CI 2.9 to 3.4) cases per person-week, respectively. Incidences were similar across occupational groups. Seropositive essential workers had a 93% reduction in the hazard (HR of 0.07, 95% CI 0.03 to 0.17) of having a positive test during the follow-up with no significant between-occupational group difference.ConclusionsA 10-fold reduction in the hazard of being virologically tested positive was observed among anti-SARS-CoV-2 seropositive essential workers regardless of their sector of occupation, confirming the seroprotective effect of a previous SARS-CoV2 exposure at least 6 months after infection.
Dietary diversity score is inversely related to the risk of polycystic ovary syndrome in Tehranian women: a case-control study
Authors: Soodi Sahel , Keshavarz Seyed Ali , Hosseini Sedighe , Abbasi Behnood 
Published: December 2021

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age and is affected by various dietary factors. Therefore, this study aimed to investigate the relationship between dietary diversity score (DDS) and the risk of PCOS. Our case-control study was conducted in the summer and autumn of 2019 in Taleghani and Arash hospitals in Tehran, Iran. A total of 494 participants (203 cases and 291 controls) were included in the study. Thereafter, their demographic information, dietary intake, and anthropometric and physical activity assessments were gathered. A validated semi-quantitative food frequency questionnaire was then used to calculate the DDS by scoring 5 food groups. To evaluate the risk of PCOS in association with DDS, the subjects were categorized based on the quartile cut-off points of the DDS. The mean ± SD age of the participants in both the case and control groups was 28.98 ± 5.43 and 30.15 ± 6.21 years, while mean ± SD body mass index was 25.74 ± 5.44 and 23.65 ± 3.90 kg/m2, respectively. The comparison between the case and control groups indicated that total DDS was 5.19 ± 1.19 for the cases and 5.51 ± 1.19 for the controls. The comparison of DDS in the highest versus the lowest quartiles showed a decreased risk of PCOS (p < 0.05). We demonstrated an inverse association between DDS and PCOS compared with the control group. Furthermore, a higher DDS was significantly associated with a lower risk of PCOS (odds ratio = 0.40). Novelty: This is the first investigation on the relationship between DDS and PCOS. Results depicted an inverse relationship between DDS and PCOS.
Quasinormal modes of a massive scalar field nonminimally coupled to gravity in the spacetime of self-dual black hole
Authors: Santos J. S. , Cruz M. B. , Brito F. A. 
Published: December 2021

AbstractIn this work, we investigate the quasinormal modes for a massive scalar field with a nonminimal coupling with gravity in the spacetime of a loop quantum black hole, known as the self-dual black hole. In this way, we have calculated the characteristic frequencies using the 3rd order WKB approach, where we can verify a strong dependence with the mass of scalar field, the parameter of nonminimal coupling with gravity, and parameters of the loop quantum gravity. From our results, we can check that the self-dual black hole is stable under the scalar perturbations when assuming small values for the parameters. Also, such results tell us that the quasinormal modes assume different values for the cases where the mass of field is null and the nonminimal coupling assumes $$\xi =0$$

ξ
=
0

and $$\xi =1/6$$

ξ
=
1
/
6

, i.e., a possible breaking of the conformal invariance can be seen in the context of loop quantum black holes.
Neutrino interaction physics in neutrino telescopes
Authors: Katori Teppei , Yanez Juan Pablo , Yuan Tianlu 
Published: December 2021

AbstractNeutrino telescopes can observe neutrino interactions starting at GeV energies by sampling a small fraction of the Cherenkov radiation produced by charged secondary particles. These experiments instrument volumes massive enough to collect substantial samples of neutrinos up to the TeV scale as well as small samples at the PeV scale. This unique ability of neutrino telescopes has been exploited to study the properties of neutrino interactions across energies that cannot be accessed with man-made beams. Here, we present the methods and results obtained by IceCube, the most mature neutrino telescope in operation, and offer a glimpse of what the future holds in this field.
Recent highlights from GENIE v3
Authors: Alvarez-Ruso Luis , Andreopoulos Costas , Ashkenazi Adi , Barry Christopher , Dennis Steve , Dytman Steve , Gallagher Hugh , Soto Alfonso Andres Garcia , Gardiner Steven , Giele Walter , Hatcher Robert , Hen Or , Jiang Libo , Kakorin Igor D. , Kuzmin Konstantin S. , Meregaglia Anselmo , Naumov Vadim A. , Papadopoulou Afroditi , Roda Marco , Syrotenko Vladyslav , Tena-Vidal Júlia , Wolcott Jeremy , Wright Natalie , Kabirnezhad Monireh , Vololoniaina Narisoa 
Published: December 2021

AbstractThe release of GENIE v3.0.0 was a major milestone in the long history of the GENIE project, delivering several alternative comprehensive neutrino interaction models, improved charged-lepton scattering simulations, a range of beyond the Standard Model simulation capabilities, improved experimental interfaces, expanded core framework capabilities, and advanced new frameworks for the global analysis of neutrino scattering data and tuning of neutrino interaction models. Steady progress continued following the release of GENIE v3.0.0. New tools and a large number of new physics models, comprehensive model configurations, and tunes have been made publicly available and planned for release in v3.2.0. This article highlights some of the most recent technical and physics developments in the GENIE v3 series.
Truly Man's Best Friend: Canine Cancers Drive Drug Repurposing in Osteosarcoma
Authors: Weiss Mia C. , Eulo Vanessa , Van Tine Brian A. 
Published: December 2021

Summary
While metastatic osteosarcoma is rare in humans, it is the most common bone tumor found in any breed of dog. Given the genetic similarities between canine and human osteosarcomas, canine clinical trials allow for rapid testing and drug repurposing at a speed that cannot be achieved using patients with osteosarcoma.
See related article by Regan et al., p. 662
Epigenetic Silencing of 15-Hydroxyprostaglandin Dehydrogenase by Histone Methyltransferase EHMT2/G9a in Cholangiocarcinoma
Authors: Zhang Jinqiang , Chen Weina , Ma Wenbo , Song Kyoungsub , Lee Sean , Han Chang , Wu Tong 
Published: December 2021

AbstractCholangiocarcinoma (CCA) is a lethal malignancy with few therapeutic options. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) has been shown to inhibit CCA cell growth in vitro and in xenograft models. However, the role of 15-PGDH in CCA development has not been investigated and the mechanism for 15-PGDH gene regulation remains unclear. Here, we evaluated the role of 15-PGDH in CCA development by using a mouse model with hydrodynamic tail vein injection of transposase-based plasmids expressing Notch1 intracellular domain and myr-Akt, with or without co-injection of 15-PGDH expression plasmids. Our results reveal that 15-PGDH overexpression effectively prevents CCA development. Through patient data mining and experimental approaches, we provide novel evidences that 15-PGDH is epigenetically silenced by histone methyltransferase G9a. We observe that 15-PGDH and G9a expressions are inversely correlated in both human and mouse CCAs. By using CCA cells and mouse models, we show that G9a inhibition restores 15-PGDH expression and inhibited CCA in vitro and in vivo. Mechanistically, our data indicate that G9a is recruited to 15-PGDH gene promoter via protein–protein interaction with the E-box binding Myc/Max heterodimer. The recruited G9a then silences 15-PGDH gene through enhanced methylation of H3K9. Our further experiments have led to the identification of STAT4 as a key transcription factor involved in the regulation of 15-PGDH by G9a. Collectively, our findings disclose a novel G9a-15PGDH signaling axis which is importantly implicated in CCA development and progression.Implications:The current study describes a novel G9a-15PGDH signaling axis which is importantly implicated in CCA development and progression.
Building Tools for Machine Learning and Artificial Intelligence in Cancer Research: Best Practices and a Case Study with the PathML Toolkit for Computational Pathology
Authors: Rosenthal Jacob , Carelli Ryan , Omar Mohamed , Brundage David , Halbert Ella , Nyman Jackson , Hari Surya N. , Van Allen Eliezer M. , Marchionni Luigi , Umeton Renato , Loda Massimo 
Published: December 2021

Abstract
Imaging datasets in cancer research are growing exponentially in both quantity and information density. These massive datasets may enable derivation of insights for cancer research and clinical care, but only if researchers are equipped with the tools to leverage advanced computational analysis approaches such as machine learning and artificial intelligence. In this work, we highlight three themes to guide development of such computational tools: scalability, standardization, and ease of use. We then apply these principles to develop PathML, a general-purpose research toolkit for computational pathology. We describe the design of the PathML framework and demonstrate applications in diverse use cases. PathML is publicly available at www.pathml.com.
Low Shear Stress at Baseline Predicts Expansion and Aneurysm-Related Events in Patients With Abdominal Aortic Aneurysm
Authors: Bappoo Nikhilesh , Syed Maaz B.J. , Khinsoe Georgia , Kelsey Lachlan J. , Forsythe Rachael O. , Powell Janet T. , Hoskins Peter R. , McBride Olivia M.B. , Norman Paul E. , Jansen Shirley , Newby David E. , Doyle Barry J. 
Published: December 2021

Background:
Low shear stress has been implicated in abdominal aortic aneurysm (AAA) expansion and clinical events. We tested the hypothesis that low shear stress in AAA at baseline is a marker of expansion rate and future aneurysm-related events.

Methods:
Patients were imaged with computed tomography angiography at baseline and followed up every 6 months >24 months with ultrasound measurements of maximum diameter. From baseline computed tomography angiography, we reconstructed 3-dimensional models for automated computational fluid dynamics simulations and computed luminal shear stress. The primary composite end point was aneurysm repair and/or rupture, and the secondary end point was aneurysm expansion rate.

Results:

We included 295 patients with median AAA diameter of 49 mm (interquartile range, 43–54 mm) and median follow-up of 914 (interquartile range, 670–1112) days. There were 114 (39%) aneurysm-related events, with 13 AAA ruptures and 98 repairs (one rupture was repaired). Patients with low shear stress (<0.4 Pa) experienced a higher number of aneurysm-related events (44%) compared with medium (0.4–0.6 Pa; 27%) and high (>0.6 Pa; 29%) shear stress groups (
P
=0.010). This association was independent of known risk factors (adjusted hazard ratio, 1.72 [95% CI, 1.08–2.73];
P
=0.023). Low shear stress was also independently associated with AAA expansion rate (β=+0.28 mm/y [95% CI, 0.02–0.53];
P
=0.037).

Conclusions:
We show for the first time that low shear stress (<0.4 Pa) at baseline is associated with both AAA expansion and future aneurysm-related events. Aneurysms within the lowest tertile of shear stress, versus those with higher shear stress, were more likely to rupture or reach thresholds for elective repair. Larger prospective validation trials are needed to confirm these findings and translate them into clinical management.
Determinants of Incident Atherosclerotic Cardiovascular Disease Events Among Those With Absent Coronary Artery Calcium: Multi-Ethnic Study of Atherosclerosis
Authors: Al Rifai Mahmoud , Blaha Michael J. , Nambi Vijay , Shea Steven J.C. , Michos Erin D. , Blumenthal Roger S. , Ballantyne Christie M. , Szklo Moyses , Greenland Philip , Miedema Michael D. , Nasir Khurram , Rotter Jerome I. , Guo Xiuqing , Yao Jie , Post Wendy S. , Virani Salim S. 
Published: December 2021

Background:
The 2018 American Heart Association/American College of Cardiology/Multisociety cholesterol guideline states that statin therapy may be withheld or delayed among intermediate-risk individuals in the absence of coronary artery calcium (CAC=0). We evaluated whether traditional cardiovascular risk factors are associated with incident atherosclerotic cardiovascular disease (ASCVD) events among individuals with CAC=0 over long-term follow-up.

Methods:
We included participants with CAC=0 at baseline from the MESA (Multi-Ethnic Study of Atherosclerosis), a prospective cohort study of individuals free of clinical ASCVD at baseline. We used multivariable-adjusted Cox proportional hazards models to study the association between cardiovascular risk factors (cigarette smoking, diabetes, hypertension, preventive medication use [aspirin and statin], family history of premature ASCVD, chronic kidney disease, waist circumference, lipid and inflammatory markers) and adjudicated incident ASCVD outcomes.

Results:
We studied 3416 individuals (mean [SD] age 58 [9] years; 63% were female, 33% White, 31% Black, 12% Chinese American, and 24% Hispanic). Over a median follow-up of 16 years, there were 189 ASCVD events (composite of coronary heart disease and stroke) of which 91 were coronary heart disease, 88 were stroke, and 10 were both coronary heart disease and stroke events. The unadjusted event rates of ASCVD were ≤5 per 1000 person-years among individuals with CAC=0 for most risk factors with the exception of current cigarette smoking (7.3), diabetes (8.9), hypertension (5.4), and chronic kidney disease (6.8). After multivariable adjustment, risk factors that were significantly associated with ASCVD included current cigarette smoking: hazard ratio, 2.12 (95% CI, 1.32–3.42); diabetes: hazard ratio, 1.68 (95% CI, 1.01–2.80); and hypertension: hazard ratio, 1.57 (95% CI, 1.06–2.33).

Conclusions:
Current cigarette smoking, diabetes, and hypertension are independently associated with incident ASCVD over a 16-year follow-up among those with CAC=0.
Uncrowded Hypervolume-Based Multiobjective Optimization with Gene-Pool Optimal Mixing
Authors: Maree S.C. , Alderliesten T. , Bosman P.A.N. 
Published: December 2021

AbstractDomination-based multiobjective (MO) evolutionary algorithms (EAs) are today arguably the most frequently used type of MOEA. These methods, however, stagnate when the majority of the population becomes nondominated, preventing further convergence to the Pareto set. Hypervolume-based MO optimization has shown promising results to overcome this. Direct use of the hypervolume, however, results in no selection pressure for dominated solutions. The recently introduced Sofomore framework overcomes this by solving multiple interleaved single-objective dynamic problems that iteratively improve a single approximation set, based on the uncrowded hypervolume improvement (UHVI). It thereby however loses many advantages of population-based MO optimization, such as handling multimodality. Here, we reformulate the UHVI as a quality measure for approximation sets, called the uncrowded hypervolume (UHV), which can be used to directly solve MO optimization problems with a single-objective optimizer. We use the state-of-the-art gene-pool optimal mixing evolutionary algorithm (GOMEA) that is capable of efficiently exploiting the intrinsically available grey-box properties of this problem. The resulting algorithm, UHV-GOMEA, is compared with Sofomore equipped with GOMEA, and the domination-based MO-GOMEA. In doing so, we investigate in which scenarios either domination-based or hypervolume-based methods are preferred. Finally, we construct a simple hybrid approach that combines MO-GOMEA with UHV-GOMEA and outperforms both.
Dead-Ends and New Directions
Authors: Gomes Jean Francesco A.L. 
Published: December 2021

Abstract
The aim of this article is to investigate how Abraham Kuyper and some late neo-Calvinists have addressed the doctrine of creation in light of the challenges posed by evolutionary scientific theory. I argue that most neo-Calvinists today, particularly scholars from the Vrije Universiteit Amsterdam (VU), continue Kuyper’s legacy by holding the core principles of a creationist worldview. Yet, they have taken a new direction by explaining the natural history of the earth in evolutionary terms. In my analysis, Kuyper’s heirs at the VU today offer judicious parameters to guide Christians in conversation with evolutionary science, precisely because of their high appreciation of good science and awareness of the nonnegotiable elements that make up the orthodox Christian narrative.
Does Theology Belong in the University? Schleiermacherian Reflections from an Australian Context
Authors: Myers Ben 
Published: December 2021

Abstract
This article argues that theology belongs in the university not because of its relationship to the other disciplines but because of its relationship to the church. It discusses Schleiermacher’s understanding of theology as a practical science oriented towards Christian leadership in society. It argues that Schleiermacher’s account provides an illuminating perspective on the history of academic theology in Australia. Theology belongs in the university not for any internal methodological reasons but because of specific contextual conditions in societies like Australia where Christianity has exerted a large historical influence. The article concludes by arguing that the ecclesial orientation of university theology is compatible with the aims of public theology, given that service to the Christian community is a means by which the common flourishing of society can be promoted.