bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Hot Equal Channel Angular Processing (ECAP) Consolidation Technique in the Production of Boron Carbide(B4C)-Reinforced Aluminium Chip (AA6061)-Based Composite
Authors: Al-Alimi Sami , Lajis Mohd Amri , Shamsudin Shazarel , Yusuf Nur Kamilah , Chan Boon Loong , Didane Djamal Hissein , Rady Mohammed H. , Sabbar Huda M. , Msebawi Munthader S. 
Published: March 2021

The production of metal matrix composites (MMCs) through recycled materials is a cost-saving process. However, the improvement of the mechanical and physical properties is another challenge to be concerned. In this study, recycled aluminium 6061 (AA6061) chips reinforced with different volumetric fractions of boron carbide (B4C) were produced through hot equal channel angular processing (ECAP). Response surface methodology (RSM) was carried out to investigate the dependent response (compressive strength) with independent parameters such as different volumetric fractions (5-15%) of added contents of B4C and preheating temperature (450 – 550°C). Also, the number of passes were examined to check the effect on the mechanical and physical properties of the developed recycled AA6061/B4C composite. The results show that maximum compressive strength and hardness of recycled AA6061/B4C were 59.2 MPa and 69 HV respectively at 5% of B4C contents. Likewise, the density and number of pores increased, which were confirmed through scanning electron microscope (SEM) and atomic force microscopes (AFM) analysis. However, the number of passes enhanced the mechanical and physical properties of the recycled AA6061/B4C composite. Therefore, the maximum compressive strength and hardness achieved were 158 MPa and 74.95 HV for the 4th pass. Moreover, the physical properties of recycled AA6061/B4C composite become denser of 2.62 g/cm3 at the 1st pass and 2.67 g/cm3 for the 4th pass. Thus, it can be concluded that the B4C volumetric fraction and number of passes have a significant effect on recycled AA6061 chips.
Independent and combined effects of biotin and hemolysis on high-sensitivity cardiac troponin assays
Authors: Harley Kellisha , Bissonnette Sarah , Inzitari Rosanna , Schulz Karen , Apple Fred S. , Kavsak Peter A. , Gunsolus Ian L. 
Published: March 2021

Abstract

Objectives
This study compared the independent and combined effects of hemolysis and biotin on cardiac troponin measurements across nine high-sensitivity cardiac troponin (hs-cTn) assays.

Methods
Parallel cTn measurements were made in pooled lithium heparin plasma spiked with hemolysate and/or biotin using nine hs-cTn assays: Abbott Alinity, Abbott ARCHITECT i2000, Beckman Access 2, Ortho VITROS XT 7600, Siemens Atellica, Siemens Centaur, Siemens Dimension EXL cTnI, and two Roche Cobas e 411 Elecsys Troponin T-hs cTnT assays (outside US versions, with and without increased biotin tolerance). Absolute and percent cTn recovery relative to two baseline concentrations were determined in spiked samples and compared to manufacturer’s claims.

Results
All assays except the Ortho VITROS XT 7600 showed hemolysis and biotin interference thresholds equivalent to or greater than manufacturer’s claims. While imprecision confounded analysis of Ortho VITROS XT 7600 data, evidence of biotin interference was lacking. Increasing biotin concentration led to decreasing cTn recovery in three assays, specifically both Roche Cobas e 411 Elecsys Troponin T-hs assays and the Siemens Dimension EXL. While one of the Roche assays was the most susceptible to biotin among the nine studied, a new version showed reduced biotin interference by approximately 100-fold compared to its predecessor. Increasing hemolysis also generally led to decreasing cTn recovery for susceptible assays, specifically the Beckman Access 2, Ortho VITROS XT 7600, and both Roche Cobas e 411 Elecsys assays. Equivalent biotin and hemolysis interference thresholds were observed at the two cTn concentrations considered for all but two assays (Beckman Access 2 and Ortho VITROS XT 7600). When biotin and hemolysis were present in combination, biotin interference thresholds decreased with increasing hemolysis for two susceptible assays (Roche Cobas e 411 Elecsys and Siemens Dimension EXL).

Conclusions
Both Roche Cobas e 411 Elecsys as well as Ortho VITROS XT assays were susceptible to interference from in vitro hemolysis at levels routinely encountered in clinical laboratory samples (0–3 g/L free hemoglobin), leading to falsely low cTn recovery up to 3 ng/L or 13%. While most assays are not susceptible to biotin at levels expected with over-the-counter supplementation, severely reduced cTn recovery is possible at biotin levels of 10–2000 ng/mL (41–8,180 nmol/L) for some assays. Due to potential additive effects, analytical interferences should not be considered in isolation.
Lessons in clinical reasoning – pitfalls, myths, and pearls: the contribution of faulty data gathering and synthesis to diagnostic error
Authors: Schaller-Paule Martin A. , Steinmetz Helmuth , Vollmer Friederike S. , Plesac Melissa , Wicke Felix , Foerch Christian 
Published: March 2021

Abstract

Objectives
Errors in clinical reasoning are a major factor for delayed or flawed diagnoses and put patient safety at risk. The diagnostic process is highly dependent on dynamic team factors, local hospital organization structure and culture, and cognitive factors. In everyday decision-making, physicians engage that challenge partly by relying on heuristics – subconscious mental short-cuts that are based on intuition and experience. Without structural corrective mechanisms, clinical judgement under time pressure creates space for harms resulting from systems and cognitive errors. Based on a case-example, we outline different pitfalls and provide strategies aimed at reducing diagnostic errors in health care.

Case presentation
A 67-year-old male patient was referred to the neurology department by his primary-care physician with the diagnosis of exacerbation of known myasthenia gravis. He reported shortness of breath and generalized weakness, but no other symptoms. Diagnosis of respiratory distress due to a myasthenic crisis was made and immunosuppressive therapy and pyridostigmine were given and plasmapheresis was performed without clinical improvement. Two weeks into the hospital stay, the patient’s dyspnea worsened. A CT scan revealed extensive segmental and subsegmental pulmonary emboli.

Conclusions
Faulty data gathering and flawed data synthesis are major drivers of diagnostic errors. While there is limited evidence for individual debiasing strategies, improving team factors and structural conditions can have substantial impact on the extent of diagnostic errors. Healthcare organizations should provide the structural supports to address errors and promote a constructive culture of patient safety.
Model-based imputation of sound level data at thoroughfare using computational intelligence
Authors: Kekez Michał 
Published: March 2021

AbstractThe aim of the paper was to present the methodology of imputation of the missing sound level data, for a period of several months, in many noise monitoring stations located at thoroughfares by applying one model which describes variability of sound level within the tested period. To build the model, at first the proper set of input attributes was elaborated, and training dataset was prepared using recorded equivalent sound levels at one of thoroughfares. Sound level values in the training data were calculated separately for the following 24-hour sub-intervals: day (6–18), evening (18–22) and night (22–6). Next, a computational intelligence approach, called Random Forest was applied to build the model with the aid of Weka software. Later, the scaling functions were elaborated, and the obtained Random Forest model was used to impute data at two other locations in the same city, using these scaling functions. The statistical analysis of the sound levels at the abovementioned locations during the whole year, before and after imputation, was carried out.
Antibody display technologies: selecting the cream of the crop
Authors: Valldorf Bernhard , Hinz Steffen C. , Russo Giulio , Pekar Lukas , Mohr Laura , Klemm Janina , Doerner Achim , Krah Simon , Hust Michael , Zielonka Stefan 
Published: March 2021

Abstract
Antibody display technologies enable the successful isolation of antigen-specific antibodies with therapeutic potential. The key feature that facilitates the selection of an antibody with prescribed properties is the coupling of the protein variant to its genetic information and is referred to as genotype phenotype coupling. There are several different platform technologies based on prokaryotic organisms as well as strategies employing higher eukaryotes. Among those, phage display is the most established system with more than a dozen of therapeutic antibodies approved for therapy that have been discovered or engineered using this approach. In recent years several other technologies gained a certain level of maturity, most strikingly mammalian display. In this review, we delineate the most important selection systems with respect to antibody generation with an emphasis on recent developments.
Super-rapid race for saving lives by developing COVID-19 vaccines
Authors: Uttarilli Anusha , Amalakanti Sridhar , Kommoju Phaneeswara-Rao , Sharma Srihari , Goyal Pankaj , Manjunath Gowrang Kasaba , Upadhayay Vineet , Parveen Alisha , Tandon Ravi , Prasad Kumar Suranjit , Dakal Tikam Chand , Ben Shlomo Izhar , Yousef Malik , Neerathilingam Muniasamy , Kumar Abhishek 
Published: March 2021

Abstract
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people and claimed thousands of lives. Starting in China, it is arguably the most precipitous global health calamity of modern times. The entire world has rocked back to fight against the disease and the COVID-19 vaccine is the prime weapon. Even though the conventional vaccine development pipeline usually takes more than a decade, the escalating daily death rates due to COVID-19 infections have resulted in the development of fast-track strategies to bring in the vaccine under a year’s time. Governments, companies, and universities have networked to pool resources and have come up with a number of vaccine candidates. Also, international consortia have emerged to address the distribution of successful candidates. Herein, we summarize these unprecedented developments in vaccine science and discuss the types of COVID-19 vaccines, their developmental strategies, and their roles as well as their limitations.
Adult-onset citrullinaemia type II with liver cirrhosis: A rare cause of hyperammonaemia
Authors: Chen Pingrun , Gao Xin , Chen Bin , Zhang Yan 
Published: March 2021

Abstract
Adult-onset citrullinaemia type II (CTLN2) is a rare disease in Chinese patients. As a subtype of citrin deficiency (CD), it is an autosomal recessive disease related to the SLC25A13 mutation on chromosome 7q21.3. In this study, we report a case of CTLN2 presenting with paroxysmal altered consciousness and refractory hyperammonaemia. The diagnosis was finally confirmed by gene analysis. The patient recovered after liver transplantation. It can be learned from this case that CD should be considered in patients with refractory hyperammonaemia and paroxysmal mental disorder without a history of liver disease.
Nuove ricerche sull’Attila Flagellum Dei di Nicolò da Càsola
Authors: Beretta Andrea 
Published: March 2021

Abstract
My article focuses on the Franco-Italian poem Attila Flagellum Dei, composed by Nicolò da Càsola, an Italian notary, in the second half of the XIV century for the Estensi in Ferrara, in order to celebrate the heroic origins of the family: actually, it is the first encomiastic poem dedicated to them, before the major works by Boiardo and Ariosto. The poem is witnessed by a single manuscript (divided into two tomes), supposedly in the hand of the author himself. My study provides a new biographic profile of Nicolò and his family, also through an overview of some archival documents from the Archivio di Stato in Bologna. The article also presents a brief summary of the narration, and outlines the principal characters, the positive ones (Forest and Gilius in particular) as well as the negative ones (Attila), seen as prototypes alluding to other fictional or historical figures (Forest = Hector of Troy; Attila = the entire Visconti’s family). At last, my paper offers a sample (the proem) of the critical and commented edition I am working at. The text is preceded by an analysis that illustrates its peculiar linguistic features, with a particular regard on the rhymes: indeed, far from being representative of the generic class of Franco-italian works composed by Italo-Romance authors, the poem Attila Flagellum Dei shows a combination of hypercharacterized French and Italo-Romance dialects of Northern Italy.
Neural Development of Speech Sensorimotor Learning
Authors: Ohashi Hiroki , Ostry David J. 
Published: March 2021

The development of the human brain continues through to early adulthood. It has been suggested that cortical plasticity during this protracted period of development shapes circuits in associative transmodal regions of the brain. Here we considered how cortical plasticity during development might contribute to the coordinated brain activity required for speech motor learning. Specifically, we examined patterns of brain functional connectivity (FC), whose strength covaried with the capacity for speech audio-motor adaptation in children ages 5–12 and in young adults of both sexes. Children and adults showed distinct patterns of the encoding of learning in the brain. Adult performance was associated with connectivity in transmodal regions that integrate auditory and somatosensory information, whereas children rely on basic somatosensory and motor circuits. A progressive reliance on transmodal regions is consistent with human cortical development and suggests that human speech motor adaptation abilities are built on cortical remodeling, which is observable in late childhood and is stabilized in adults.SIGNIFICANCE STATEMENTA protracted period of neuro plasticity during human development is associated with extensive reorganization of associative cortex. We examined how the relationship between FC and speech motor learning capacity are reconfigured in conjunction with this cortical reorganization. Young adults and children aged 5–12 years showed distinctly different patterns. Mature brain networks related to learning included associative cortex, which integrates auditory and somatosensory feedback in speech, whereas the immature networks in children included motor regions of the brain. These patterns are consistent with the cortical reorganization that is initiated in late childhood. The result provides insights into the human biology of speech as well as to the mature neural mechanisms for multisensory integration in motor learning.
Formation of a portfolio of energy saving projects at metallurgical enterprise
Authors: Kiyko S. 
Published: March 2021

Purpose. To build a model of project selection for the portfolio in accordance with the energy strategy of the metallurgical enterprise. The urgency of solving these issues for the metallurgical industry of Ukraine is caused by the need to improve the economic stability of enterprises, increase the competitiveness of products and reduce dependence on energy suppliers.
Methods. Methods of program and portfolio management, system approach, models and methods of strategic management in the field of project management and mathematical apparatus of set theory are used in formalizing the model of forming a portfolio of energy saving projects at a metallurgical enterprise.
Results. The analysis of the general problem of portfolio management of energy saving projects at metallurgical enterprises is performed. The main stages of formation and implementation of the portfolio of energy saving projects of the metallurgical enterprise are considered in detail. A formalized mathematical model for the selection of energy saving projects at a metallurgical enterprise for the portfolio has been developed. With the help of the proposed approach and models, a portfolio of projects of the metallurgical enterprise PJSC “Dniprospetsstal” was formed, which included promising projects for implementation in accordance with the energy strategy.
Scientific novelty. A model of project portfolio formation in accordance with the energy efficiency strategy of a metallurgical enterprise has been developed, which comprehensively takes into account the current state of the enterprise and its future strategic directions, resource and financial support of energy saving projects and risks of adverse events.
Practical meaning. The use of this model allows consistent analysis of portfolio projects in order to identify opportunities for their implementation at the metallurgical enterprise, to coordinate project implementation plans and plans at different levels of planning, to select the most promising projects for implementation in accordance with the energy strategy.
Surface-Wave Simulation for the Continuously Moving Seismic Sources
Authors: Yan Yuefeng , Sun Chengyu , Lin Tengfei , Wang Jiao , Yang Jidong , Wu Dunshi 
Published: March 2021

Abstract
In exploration and earthquake seismology, most sources used in subsurface structure imaging and rock property estimation are fixed in certain positions. Continuously moving seismic sources, such as vehicles and the metro, are one kind of important passive sources in ambient noise research. Commonly, seismic data acquisition and processing for moving sources are based on the assumption of simple point passive sources, and the dispersion curve inversion is applied to constrain near-surface velocity. This workflow neglects the Doppler effects. Considering the continuously moving properties of the sources, we first derive the analytical solution for the Rayleigh waves excited by heavy vehicles and then analyze their Doppler effects and dispersion curves. We observe that the moving source data have the Doppler effect when compared with the changes in the frequency of the source intensity, but this effect does not affect the frequency dispersion of Rayleigh waves. The dispersion curves computed for moving source records are consistent with the analytical dispersion solutions, which provide a theoretical foundation for velocity estimation using moving source data.
PENINGKATAN FUNGSI TRANSFORMATIF KHOTBAH JUMAT DI MASJID-MASJID SRIHARDONO PUNDONG BANTUL
Authors: Marsudi Marsudi , Ilyas Yunahar 
Published: March 2021

Khotbah Jumat di masjid-masjid wilayah Pundong Bantul, dilakukan sekedar sebagai ritual rutin penggugur kewajiban. Fungsi yang ditonjolkan adalah fungsi normative ‘ubudiyyah, bukan fungsi transformatifnya. Ditemukan beberapa masalah, yaitu rendahnya kompetensi profesional dan pedagogik para khatib, persebaran khatib yang kurang merata serta bacaan al-Qur`an dan Hadits para khatib dan imam belum fasih dan benar. Persoalan-persoalan tersebut dipecahkan dengan menyelenggarakan pelatihan intensif khatib dan imam salat, studi lapangan di masjid-masjid ideal serta penjadwalan khatib terpadu dengan aplikasi berbasis Microsoft Excel. Hasil pelatihan menunjukkan adanya peningkatan kompetensi profesional dan pedagogik khatib yang cukup signifikan dari skor rata-rata sebesar 65,9 (Pretest) menjadi 79,3 (Posttest). Para khatib menjadi lebih paham tentang fiqh, adab-adab dan retorika khotbah.Terkait kualitas bacaan al-Quran, pelatihan berhasil menumbuhkan kesadaran para khatib akan kemampuan diri mereka dalam membaca al-Qur`an dan Hadits yang masih di bawah standar. Para khatib menyepakati untuk membuat kegiatan belajar membaca al-Qur`an dan Hadits bersama sebagai tindak lanjut pelatihan. Adapun kegiatan penjadwalan khatib terpadu yang dilakukan oleh Bagian Tabligh dan Kemasjidan Pimpinan Ranting Muhammadiyah Srihardono Pundong dengan menggunakan aplikasi berbasis Microsoft Excel berhasil mengatasi kurangnya personel khatib di masjid-masjid tertentu.
Emphasise the role of kangaroo mother care in stabilisation of vitals and weight gain pattern in low birth weight babies inside neonatal intensive care unit
Authors: Bhatt Shwetal M. , Mehta Khushboo N. , Maheshwari Ankita , Parmar Priyanka C. 
Published: March 2021

Background: Kangaroo mother care (KMC) is routinely practiced in post-natal wards for care of stable low birth weight (LBW) infants. Objectives of the study were conducted to emphasize on the role of KMC in vitals stabilization and weight gain in LBW babies inside neonatal intensive care unit (NICU).Methods: Cross-sectional analytical quantitative study.Results: A total of 80 babies (48 males and 32 females) were enrolled and given KMC inside NICU. Mean birth weight was 1330 grams. Mean gestational age was 33 weeks (range 30-38 weeks). KMC was initiated within 72 hours of life in majority of babies (71%). Though 65% of them required oxygen support via prongs, KMC was started in them, with monitoring of vitals. No episode of apnea was observed during KMC sessions. Mean duration of KMC was 6 days (3-14 days). Heart rate dropped by 3-4 beats per minute (150+2.12 to 146+1.63, Respiratory rate decreased from 53+3.9 to 49+2.7, Oxygen saturation improved by 2-3% (93+0.42 to 96+0.71). Temperature rose from 36.78+0.01 to 37.07+0.02. P value for all vitals was 0.0001, which is considered significant (<0.05). Average weight gain was 76 grams during the average 6 days of KMC inside NICU, (p value=0.0001). Conclusions: KMC was found to be effective for stabilization of vitals in NICU, early initiation and upgradation of feeding, early achievement of weight gain pattern, and early shift to postnatal ward by mother’s side. Also, no adverse effects were noted on the babies.
Análise Comparativa da Correspondência entre Comer e Relatar de Crianças e Adultos
Authors: Ferreira Makerley , Neves Sônia Maria Mello , Simonassi Lorismário Ernesto , Andrade Marise , Pires Dias Doralice Oliveira 
Published: March 2021

Resumo: investigou-se o efeito do reforçamento das verbalizações relativas ao comportamento de comer e sua correspondência ou não com o comer em quatro crianças obesas e quatro com IMC normal ou abaixo da média e, quatro adultos acima do peso e quatro com IMC normal. Observou-se correspondência entre o comer e o relatar em crianças e adultos obesos e não obesos.
Palavras-chave: Obesidade. Comportamento Verbal. Auto-relato. Correspondência.
VEGETATION INDICES AND THEIR CORRELATION WITH SECOND-CROP CORN GRAIN YIELD IN MATO GROSSO DO SUL, BRAZIL
Authors: HENRIQUES HERMANO JOSÉ RIBEIRO , SCHWAMBACH DÁRIO ALEXANDRE , FERNANDES VANESSA JORDÃO MARCATO , CORTEZ JORGE WILSON 
Published: March 2021

The emergence of satellites covering new electromagnetic wavelengthsallowed developing different vegetation indices, enabling the study of theircorrelation with grain yield. In this sense, this study aimed to evaluate the accuracy between the mean values of seven vegetation indices and the mean corn grain yield in the field by applying linear regression equations. The indices NDVI, NDRE, GNDVI, GRNDVI, and PNDVI were used, with changes proposed in the equations of the indices GRNDVI and PNDVI, in which the red wavelength was replaced by the red edge. The multispectral bands provided by the Sentinel-2A and Sentinel-2B imaging instruments were used as a source of data to calculate the vegetation indices, while the values recorded by the grain harvester were used for the survey of grain yield data. A high correlation was observed between indices and grain yield. The replacement of the red wavelength with the red edge improves the correlation between vegetation indices and grain yield. Moreover, the indices GNDVI and NDVI easily saturate, reaching maximum values and not allowing the distinction between sample classes. Therefore, the vegetation indices PRENDVI and GRENDVI are recommended for estimating grain yield.