bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Validity and Accuracy of 3D-printed Patient-specific Instruments for High Tibial Osteotomy: A Cadaveric Study
Authors: Miao Zhuang , Li Songlin , Luo Desu , Lu Qunshan , Liu Peilai 
Published: December 2021

Abstract
Objective High tibial osteotomy (HTO) has been used for the treatment of patients with knee osteoarthritis. However, the successful implementation of HTO requires precise intraoperative positioning, which places greater requirements on the surgeon. In this study, we aimed to design a new kind of 3D-printed patient-specific instrument (PSI) for HTO, including a positioning device and an angle bracing spacer, and verify its effectiveness using cadaveric specimens.Methods This study included ten fresh human lower limb cadaveric specimens. Computed Tomography(CT) and X-ray examinations were performed to make preoperative plans. PSI was designed and 3D-printed according to the preoperative plan. Then, the PSI was used to guide HTO. Finally, we performed X-ray and CT after the operation to verify its validity and accuracy.Results The PSI use process was adjusted according to the pre-experimental procedure in 1 case. Hinge fracture occurred in 1 case. According to X-rays of the remaining 8 cadaveric specimens, no statistically significant difference was noted between the preoperative planning medial proximal tibial angle (MPTA) and postoperative MPTA (P > 0.05) or the preoperative and postoperative posterior slope angle (PSA) (P > 0.05). According to the CT of 10 cadaveric specimens, no statistically significant difference was noted between the design angle and actual angle, which was measured according to the angle between the osteotomized line and the cross-section (P > 0.05). The gap between the designed osteotomy line and the actual osteotomy line was 2.09(0.8~3.44) mm in the coronal plane and 1.58(0.7~2.85) mm in the sagittal plane.Conclusion This 3D-printed PSI of HTO accurately achieves the angle and position of the preoperative plan without increasing the stripping area. However, its use still requires a certain degree of proficiency to avoid complications, such as hinge fracture.
Flow Resistance in Lowland Rivers Impacted with Distributed Aquatic Vegetation
Authors: Okhravi Saeid , Schügerl Radoslav , Velísková Yvetta 
Published: December 2021

Abstract
The study addresses the research concern that the employment of fixed value for bed roughness coefficient in lowland rivers (mostly ‌sand-bed rivers) is deemed practically questionable in the presence of a mobile bed and time-dependent changes in vegetation patches. To address this issue, we set up 45 cross-sections in four lowland streams to investigate seasonal flow resistance values within a year. The results first revealed that the significant sources of boundary resistance in lowland rivers with lower regime flow are bed forms and aquatic vegetation. Then, the study uses flow discharge as an influential variable reflecting the impacts of the above-mentioned sources of resistance to flow. The studied approach ended up with two new flow resistance predictors which simply connect dimensionless unit discharge with flow resistance factors, Darcy-Weisbach (f) and Manning (n) coefficients. A comparison between the computed and measured flow resistance values indicates that 87-89% of data sets were within the ±20% error bands. The flow resistance predictors are also verified against large independent sets of field and flume data. The obtained predictions using the developed predictors may overestimate flow resistance factors to about 40% for other lowland rivers. From a different view of this research, the findings on seasonal variation of vegetation abundance hint at the augmentation in flow resistance values, both f, and n, in low summer flows when the vegetation covers river bed and side banks. The highest amount of flow resistance was observed during the summer period, July-August.
Comprehensive Analysis to Identify the Vasohibin1 (VASH1) Emerges as a Novel Prognosis Biomarker in High-Risk Low-Grade Glioma
Authors: aili Yirizhati , maimaiti Aierpati , maimaitiming Nuersimanguli , qin Hu , Ji Wenyu , mahemuti Yusufu , liu Wen , wang Yongxin , Wang Zengliang 
Published: December 2021

Abstract
Background: Gliomas are complex and heterogeneous central nervous system tumors, with Low-grade Glioma (LGG)as the most common pathological type. But studies on the predictive effect of a single gene on LGG are limited. VASH1 is an epigenetic regulator with various tumors. However, the role of VASH1 in LGG remains confused. This is the first research focusing on the prognostic value and underlying mechanism of VASH1 in LGG.Methods: In this research, three independent datasets were used for mRNA-related analysis: two datasets from the TCGA and CGGA (CGGA-mRNA seq 693 and CGGA-mRNA seq 325). We analyzed and screened the clinical significance of VASH1 in overall survival and DSS of various cancers. TIMER and CIBERSORT algorithms were employed to investigate the effect of VASH1 on the tumor microenvironment. GSEA along with GO and KEGG enrichment analyses were conducted to uncover the biological functions of VASH1. In addition, a LGG patient cohort (The First Affiliated Hospital of Xinjiang Medical University) was utilized for analysis of cell infiltration by immunohistochemical, Western-blot, and qPCR; then to verify its function in regulating LGG progression in vitro.Result: In this study, the results of generalized cancer survival analysis showed that abnormal VASH1 expression was associated with poor prognosis (overall survival (OS) and disease-specific survival (DSS) in patients with adrenal cortical carcinoma (ACC), low-grade glioma (LGG), pancreatic adenocarcinoma (PAAD) and hepatocellular carcinoma (LIHC) (P<0.05). Meanwhile, VASH1 was correlated with the immune invasion, immune score, immune checkpoint, and TBM of the above four tumors, and the correlation between VASH1 expression and LGG was the strongest. In addition, we found that VASH1-mediated changes in gene expression are closely related to cell cycle, P53, Notch, and TGF-β signaling pathways. In addition, immunostaining and RT-PCR were performed on our cohort, and the results showed that VASH1 expression was significantly higher than that of para-cancer tissues (P<0.05). Kaplan-Meier survival analysis results showed that VASH1 was associated with shorter survival (OS) and shorter DFS in high-risk LGG patients (P<0.05). Multivariate Cox analysis showed that high VASH1 expression was an independent risk factor for the prognosis of LGG patients (HR=1.65, P=0.02). Finally, a high level of VASH1 was found in U-251 cell lines by in vitro cell experiments, and the migration and invasion ability of U-251 cells were significantly improved after knockdown of VASH1 (P<0.01), which further confirmed the function of VASH1.Conclusion: In conclusion, this study preliminarily indicates that VASH1 can be used as a prognostic biomarker and potential therapeutic target for LGG, and has important clinical application value.
Manipulating local environment of atomically dispersed Fe electrocatalyst for high energy and long cycle Li-S pouch cell
Authors: Lim Won-Gwang , Park Cheol-Young , Jung Hyeonjung , Kim Seoa , Kang Seok Hun , Lee Young-Gi , Jeong Yo Chan , Yang Seung Bo , Sohn Kwonnam , Han Jeong Woo , Lee Jinwoo 
Published: December 2021

Abstract
High-energy lithium-sulfur (Li-S) pouch cell are limited by the insufficient capacities and stabilities of their cathodes under practical electrolyte/sulfur (E/S), electrolyte/capacity (E/C), and negative/positive (N/P) ratios. Herein, we fabricated an advanced cathode comprising highly active Fe single atom catalysts (SACs) and porous carbon to attain 361.8 W h kg−1 Li-S pouch cells satisfying low E/S (2.0), E/C (1.9), and N/P (2.3) ratios with high sulfur loadings (8.4 mg cm−2). We designed high-activity Fe SACs by manipulating their local environments using electron exchangeable binding (EEB) sites. Introducing EEB sites composed of two different types of S species, namely, thiophene-like-S and oxidized-S, adjacent to Fe SACs, promoted the kinetics of the Li2S redox reaction by providing additional binding sites and modulating the Fe d-orbital levels via electron exchange with Fe. This desirable cathode electrocatalysis is maximized by the intimate contact of Fe SACs with the S species, confined together into porous carbon.
Comparative Safety of Immune Checkpoint Inhibitors and Chemotherapy in Advanced Non-Small Cell Lung Cancer: A Systematic Review and Network Meta-Analysis
Authors: Chen Ching-Yi , Huang Chi-Hsien , Chen Wang-Chun , Huang Ming-Shyan , Wei Yu-Feng 
Published: December 2021

Abstract
Backgrounds: Immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy (CT) are the standard of care for first-line therapy in metastatic non-small cell lung cancer (NSCLC) patients without actionable mutations. The safety ranking of different ICI and CT combination regimens has not been investigated. This study was aimed to provide a toxicity profile and safety ranking of different ICI and CT combination regimens.Methods: We performed comprehensive searches of phase 2 and 3 randomized clinical trials (RCTs) comparing different ICI regimens (alone or combination) or CT for the first-line treatment of advanced NSCLC. Outcomes of interest were the cumulative incidence of any treatment-related adverse events (TRAEs), grade 3-5 TRAEs (grade 3-5), any immune-related adverse events (irAEs), and grade 3-5 irAEs (grade 3-5). Odds ratios and 95% credible intervals were calculated as summary statistics to quantify the effect of different ICI combination regimens. Results: We included 23 RCTs from 2016 to 2021 with a total of 14,378 patients. The incidence of any TRAEs and grade 3-5 TRAEs ranked from high to low were ICI-CT (probability: 74.88%), ICI-ICI-CT (50.60%), CT alone (74.79%), ICI-ICI (98.37%), and ICI monotherapy (99.37%). Adding CT to ICI regimens resulted in a higher incidence of any grade or grade 3-5 TRAEs compared to ICI-ICI combinations or ICI monotherapy. However, ICI-ICI-CT combinations did not result in a higher incidence of TRAEs than ICI-CT combinations. For any irAEs and grade 3-5 irAEs, the ranking was ICI-ICI (probability: 97.38), ICI monotherapy (96.98%), ICI-CT (99.44%), and CT alone (99.98%). Notably, the incidence of any grade and grade 3-5 irAEs was lower when adding CT to ICI monotherapy. Conclusion: Lack of head-to-head comparisons, these findings provide evidence for clinical decision-making when considering different ICI combination regimens for advanced NSCLC patients.
Triticum Aestivum L. cv. Guizi 1 ANS-6D Positively Regulates Leaf Senescence Through the Abscisic Acid Mediated Chlorophyll Degradation in Tobacco
Authors: Li Luhua , An Chang , Wang Zhongni , Xiong Fumin , Wang Yingxi , Ren Mingjian , Xu Ruhong 
Published: December 2021

Abstract
Anthocyanidin synthase (ANS) is involved in the synthesis of anthocyanins, which are important phytonutrients because of their beneficial effects on human health. Here, we identified ANS-6D of purple-colored Triticum aestivum L. cv. Guizi 1 (Gz) that is involved in leaf senescence through the abscisic acid (ABA) mediated chlorophyll degradation pathway in tobacco. After characterizing the leaf-senescence phenotype in GzANS-6D overexpression (OxGzANS-6D) lines, we found that the increased anthocyanin accumulation and decreased chlorophyll content in OxGzANS-6D lines were closely correlated with the expression levels of anthocyanin synthesis-related structural genes and senescence marker genes, as well as the accumulation of reactive oxygen species. The endogenous ABA content increased and ethylene content decreased in OxGzANS-6D transgenic lines compared with wild type. Additionally, the levels of the abscisic acid-responsive transcription factors ABF1 and ABF2, as well as those of chlorophyll degradation-related genes (PAO, NYC, SGR and CHL), were significantly higher in OxGzANS-6D transgenic lines than in wild type. Furthermore, we found that GzABF1 and NtABF1 binds to the promoter of GzANS-6D, and NtABF2 binds to the promoter of NtSGR. Thus, GzANS-6D participated in leaf senescence through ABA-mediated chlorophyll degradation, and ABF1/2 play important role in GzANS-6D functions.
Persistence of fecal indicator bacteria and associated genetic markers from wastewater treatment plant effluents in freshwater microcosms
Authors: Chern Eunice C. , Wymer Larry , Brenner Kristen , Oshima Kevin , Haugland Richard A. 
Published: December 2021

AbstractLimited information exists on the environmental persistence of genetic markers for fecal indicator bacteria (FIB) in treated wastewaters. Here, the decay rate constants of culturable cells and genetic markers for four diverse groups of FIBs, such as enterococci, Clostridium, Escherichia coli, and Bacteroides, were investigated in freshwater microcosms seeded with disinfected and non-disinfected secondary-treated wastewaters. Decay rate constants of genetic markers and culturable cells varied significantly among the different FIB groups. Water temperatures (winter vs. fall/spring/summer) significantly affected the decay of all genetic marker and cell types; however, genetic marker decay were not found to be significantly different in disinfected (chlorination/ultraviolet) and non-disinfected wastewater-seeded microcosms or, for example, lake- and river-receiving waters. No evidence was seen that decay rate constants of FIB genetic markers from treated wastewater were substantially different from those observed in similar, previously reported microcosm studies using raw sewage. Unexpected relationships between decay rate constants of genetic markers and culturable cells of Bacteroides were observed. Results suggest that decay rate constants of FIB genetic markers determined from other studies may be applicable to treated wastewaters. Results of this study should be informative for ongoing efforts to determine the persistence of FIB genetic markers relative to surviving pathogens after wastewater treatment.
Hubungan Kualitas Komunikasi Guru Dan Siswa Dengan Motivasi Belajar Matematika
Authors: Munawaroh Qomsi Atun 
Published: December 2021

Tujuan penelitian ini adalah untuk mengetahui adanya hubungan antara kualitas komunikasi guru dan siswa dengan motivasi belajar matematika siswa MI. Metode penelitian yang digunakan kuantitatif korelasional, dan dilaksanakan di MI Muhammadiyah Potronayan 1 Nogosari Boyolali di mulai bulan Oktober 2020 sampai maret 2021. Populasi dalam penelitian ini adalah seluruh siswa kelas tinggi di MI Muhammadiyah se- Kecamatan Nogosari Boyolali. Pengambilan sampel dengan teknik cluster sampling sebanyak 63 siswa. Teknik pengumpulan data menggunakan angket yang telah diuji validitas dan reliabilitasnya. Berdasarkan hasil penelitian: Tingkat kualitas komunikasi guru dan siswa termasuk kedalam kategori baik yaitu sebesar 68,25%. Motivasi belajar matematika siswa kelas tinggi berada dalam kategori sedang yaitu sebesar 61,90%. Berdasarkan perhitungan nilai koefisien determinasi (R2) sebesar 17,8%. Hasil uji korelasi dengan r hitung = 0,422, r tabel = 0,244, maka diperoleh r hitung r tabel, yang menunjukkan terdapat hubungan yang positif antara kualitas komunikasi guru dan siswa dengan motivasi belajar matematika
A LATERAL APPROACH TO ETHICS IN BUSINESS
Authors: Piskrzyńska Katarzyna , Cieślar Szymon 
Published: December 2021

Ethical issues in enterprises are often discussed in the scientific studies. Most of them describe organizational ethics from the perspective of corporate social responsibility or its impact on the behavior of employees in the organization. The authors decided to depart from the schematic formulaic thinking of ethics as a set of normative values for a purely business approach. Looking for opportunities to use organizational ethics in promotional activities or when determining the value of goods and services. The aim of this article is to present selected approaches to ethical issues in the organization and to present the results of authors’ our research. The Authors in their study use research methods such as literary research and primary research using the survey tool. Surveys were conducted in Poland in the period from January 2017 to October 2017 and they included a random sample of respondents. The main hypothesis was also formulated: H0: Ethics in the enterprise can be purely binary, For the purpose of the study, the following hypotheses were formulated: H1: Ethics can be used to shape prices H2: Ethics affects consumers' decisions H3: Unethical behaviors in the enterprise worsen its competitiveness, In addition, this publication underlines individual moral considerations of the ethical aspects of using ethics in the enterprise to increase profits and thereby create a paradox of unethical use of ethics.
THE ANALYSIS OF PRE AND POST NEGOTIATION OF FRAMING AND PARTNER’S OBJECTIVE ON TRANSFER PRICES
Authors: Arief Sandy , Supriyono Supriyono 
Published: December 2021

Transfer price negotiations are important to managers as they influence both their own and other divisional profits. These transfer prices are affected by both economic factors (market prices) and behavioral factors including fairness on judgments about negotiated transfer prices. In the current study, we examine whether the impact of accounting information on managers’ transfer price expectations are affected by the way accounting information is framed (either as potential gains or potential losses) and the managers’ perception of the other negotiation partners’ objective (whether their partner’s objective involves high or lowconcern-for-others). These expectations are important as they directly affect the costs and outcomes of negotiations. A controlled laboratory experiment was conducted to test the proposed hypotheses, using a 2 x 2 x 2 between-subjects design. The participants of an experiment were 216 undergraduate accounting students from Faculty of Economics and Business, Soegijapranata Catholic University, Semarang. The results of this study that compared to the mainframe, a loss frame exacerbates managers’ self-serving bias and increases the transfer price expectation gap between buyers and sellers. Further, we found that the negotiation partner’s objective had a significant impact on sellers’ transfer price judgments. This finding also found that the degree of concern for the other party has a significant impact on the judgment, in particular, the transfer price for the seller division.
Comparative Governance of Non-Profit Organization
Authors: Sugiyanto Sugiyanto , Tjahjono Heru Kurnianto , Hartono Arief , Khuluq Lathiful 
Published: December 2021

The research on comparative governance of non-profit organization (organisasi nir laba/ ONL) in case study on social welfare institution (lembaga kesejahteraan social/ LKS) of Mardi Wuto dan Hamba in Yogyakarta Indonesia aimed at finding out the difference of the governance model and practice of both LKS and the uniqueness of each LKS. LKS was one of non-profit organizations in Indonesia. The empirical data were obtained and the finding was described and interpreted based on qualitative case study. The interpretation was related to the normative expectation on the design and implementation of the management of both non profit organizations.
The research finding of ONL Mardiwuto was that it had bureaucratic governance model indicated by the good interaction and relation of the stakeholders, as the value management stated on articles of association. Meanwhile, ONL Hamba had democratic governance model indicated by the very good interaction and relation of the stakeholders, beyond the value management stated on articles of association. The weakness of the research was that the sample was still limited. Then, for the future research, it was suggested that the sample would be more various, and the implication of the research was it could be a reflection material for the decision makers and the managers of ONL.
Estudos sociocríticos e/ou pedagogias críticas em Educação Física: na, da ou desde a América Latina? (Estudios sociocríticos y/o pedagogías críticas en Educación Física: ¿en, de o desde América Latina?)
Authors: Q. de Almeida Felipe 
Published: December 2021

Este artigo reflete sobre as condições de possibilidade de uma pedagogia crítica e/ou de estudos sociocríticos originalmente latino-americanos. Para tanto, fundamenta-se em uma descrição de experiências críticas em Educação Física de cinco distintas realidades da América do Sul (Brasil, Argentina, Colômbia, Uruguai e Chile). Analisa as dificuldades de estudos sociocríticos e/ou pedagogias críticas tipicamente latino-americanos, oportunidade para defender a interlocução, nos marcos da modernidade, entre os desenvolvimentos críticos acima e abaixo da linha do Equador.
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Este artículo reflexiona sobre las condiciones de posibilidad de una pedagogía crítica y/o de los estudios sociocríticos originalmente latino-americanos. Para tanto, se fundamenta en una descripción de experiencias críticas en Educación Física de cinco distintas realidades de América del Sur (Brasil, Argentina, Colombia, Uruguay y Chile). Analiza las dificultades de los estudios sociocríticos y/o pedagogías críticas típicamente latino-americanos, oportunidad para defender la interlocución, en los marcos de la modernidad, entre los desarrollos críticos arriba y abajo de línea del Ecuador.
Los iconos de Pegaso y corona en las monedas latinas de Emporiae: ¿Un simple fenómeno de copia tipológica?
Authors: Gozalbes García Helena 
Published: December 2021

Este trabajo analiza el fenómeno de difusión de los iconos del caballo alado y la figura circular en la moneda provincial acuñada por la ceca de Emporiae. Para lograr nuestros objetivos, presentamos un estudio que parte de las consideraciones propuestas por otros autores, intentando profundizar sobre aspectos concretos que no han llamado la atención de la investigación. Así, en una primera parte, analizamos el fenómeno de formación de este municipium romano. En la segunda parte de nuestro trabajo reflexionamos acerca del origen y primera evolución de la propuesta tipológica objeto de estudio. En la tercera parte, hemos intentado aproximarnos a los aspectos principales que determinaron el proceso de proyección de los iconos monetarios empuritanos en el nuevo contexto identitario de finales del siglo I a. C. y principios de la centuria siguiente.
La Segunda República en perspectiva. Pervivencias y cambios en la historiografía sobre el periodo 1931–1936
Authors: Marcos del Olmo Mª Concepción 
Published: December 2021

Artículo centrado en el resurgir de los estudios sobre el periodo 1931–1936, destacando la amplitud temática y diversidad metodológica con que se aborda ese crucial quinquenio de nuestra historia contemporánea. Se presta específica atención a la siempre polémica cuestión religiosa, hoy comprometida con aspectos y enfoques claramente superadores de las visiones reduccionistas que triunfaban en el pasado, así como a esos aspectos políticos que ya estuvieron en la base de la renovación historiográfica que tuvo lugar en los años setenta y ochenta del siglo pasado y siguen presentándose en la actualidad como uno de los más atractivos campos de análisis.
Francisco Pedro Pla Colomer y Santiago Vicente Llavata, La materia de Troya en la Edad Media hispánica. Historia textual y codificación fraseológica, Madrid, Iberoamericana–Vervuert, 2020, 278 páginas, ISBN 978-84-9192-151-6 (Iberoamericana) y 9
Authors: Movellán Luis Mireia 
Published: December 2021

Reseña de Francisco Pedro Pla Colomer y Santiago Vicente Llavata, La materia de Troya en la Edad Media hispánica. Historia textual y codificación fraseológica, Madrid, Iberoamericana–Vervuert, 2020, 278 páginas, ISBN 978-84-9192-151-6 (Iberoamericana) y 9