bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventing SARS-CoV-2 In-Hospital Infections in Cardiovascular Patients and Medical Staff: An Observational Study From the German Heart Center Berlin
Authors: Schöppenthau Doreen , Weiß Karl Jakob , Estepa-Martinez Misael , Hommel Matthias , Miera Oliver , Schoenrath Felix , Hübler Sabine , Obermeier Martin , Pieske Burkert , Stawowy Philipp 
Published: February 2021

Objective: COVID-19 is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Preventing in-hospital infections is crucial to protect patients and hospital staff.Methods: At the very beginning of the COVID-19 pandemic, the German Heart Center initiated obligatory wearing of surgical face masks for patients and employees, SARS-CoV-2 screening for all patients, and symptom-based testing for employees. In addition, access restriction, closure of outpatient departments, and postponing non-urgent procedures were implemented with community-initiated regulations.Results: During the observation period (03/16/2020–04/27/2020), 1,128 SARS-CoV-2 tests were performed in 983 persons (1.1 tests/person; 589 in patients and 394 in hospital employees). Up to 60% of the clinical workforce was tested based on symptoms and risk (62.5% symptoms, 19.3% direct or indirect contact to known COVID-19, 4.5% returnee from risk area, 13.7% without specific reason). Patient testing for SARS-CoV-2 was obligatory (100% tested). The overall prevalence of positive tests during the observation period was 0.4% (n = 5 out of 1,128 tests performed). The incidence of new infections with SARS-CoV-2 was 0.5% (n = 5 out of 983 individuals; three healthcare workers, two patients). No nosocominal infections occurred, despite a mean number of 14.8 in-hospital contacts.Conclusion: Comprehensive SARS-CoV-2 testing and surgical face masks for patients and hospital staff, in addition to others measures, are key factors for the early detection of COVID-19 and to prevent spreading in the vulnerable hospital population.
A Show of Ewald's Law: I Horizontal Semicircular Canal Benign Paroxysmal Positional Vertigo
Authors: Zhang Xueqing , Bai Yanru , Chen Taisheng , Wang Wei , Han Xi , Li Shanshan , Liu Qiang , Wen Chao 
Published: February 2021

Objective: To evaluate horizontal semicircular canal (HSC) effects according to Ewald's law and nystagmus characteristics of horizontal semicircular canal benign paroxysmal positional vertigo (HSC-BPPV) in the supine roll test.Methods: Patients with HSC-BPPV (n = 72) and healthy subjects (n = 38) were enrolled. Latency, duration, and intensity of nystagmus elicited by supine roll test were recorded using video nystagmography.Results: In patients with HSC-BPPV, horizontal nystagmus could be elicited by right/left head position (positional nystagmus) and during head-turning (head-turning nystagmus), and nystagmus direction was the same as that of head turning. Mean intensity values of head-turning nystagmus in HSC-BPPV patients were (44.70 ± 18.24)°/s and (44.65 ± 19.27)°/s on the affected and unaffected sides, respectively, which was not a significant difference (p = 0.980), while those for positional nystagmus were (40.81 ± 25.56)°/s and (17.69 ± 9.31)°/s (ratio, 2.59 ± 1.98:1), respectively, representing a significant difference (p &lt; 0.0001). There was no positional nystagmus in 49 HSC-BPPV patients after repositioning treatment, nor in the 38 healthy subjects. No significant difference in head-turning nystagmus was detected in HSC-BPPV patients with or without repositioning.Conclusions: The direction and intensity of nystagmus elicited by supine roll test in patients with HSC-BPPV, was broadly consistent with the physiological nystagmus associated with a same HSC with single factor stimulus. Our findings suggest that HSC-BPPV can be a show of Ewald's law in human body.
Characterization of Mechanical Allodynia and Skin Innervation in a Mouse Model of Type-2 Diabetes Induced by Cafeteria-Style Diet and Low-Doses of Streptozotocin
Authors: Castañeda-Corral Gabriela , Velázquez-Salazar Norma B. , Martínez-Martínez Arisai , Taboada-Serrano Juanita N. , Núñez-Aragón Pablo N. , González-Palomares Laura , Acosta-González Rosa Issel , Petricevich Vera L. , Acevedo-Fernández Juan José , Montes Sergio , Jiménez-Andrade Juan Miguel 
Published: February 2021

Background: Painful distal symmetrical polyneuropathy (DPN) is a frequent complication of type-2 diabetes mellitus (T2DM) that commonly presents as neuropathic pain and loss of skin nerve fibers. However, there are limited therapies to effectively treat DPN and many of the current animal models of T2DM-induced DPN do not appear to mirror the human disease. Thus, we validated a DPN mouse model induced by a cafeteria-style diet plus low-doses of streptozotocin (STZ).Methods: Female C57BL/6J mice were fed either standard (STD) diet or obesogenic cafeteria (CAF) diet for 32 weeks, starting at 8 weeks old. Eight weeks after starting diets, CAF or STD mice received either four low-doses of STZ or vehicle. Changes in body weight, blood glucose and insulin levels, as well as oral glucose- and insulin-tolerance tests (OGTT and ITT) were determined. The development of mechanical hypersensitivity of the hindpaws was determined using von Frey filaments. Moreover, the effect of the most common neuropathic pain drugs was evaluated on T2DM-induced mechanical allodynia. Finally, the density of PGP -9.5+ (a pan-neuronal marker) axons in the epidermis from the hindpaw glabrous skin was quantified.Results: At 22–24 weeks after STZ injections, CAF + STZ mice had significantly higher glucose and insulin levels compared to CAF + VEH, STD + STZ, and STD + VEH mice, and developed glucose tolerance and insulin resistance. Skin mechanical sensitivity was detected as early as 12 weeks post-STZ injections and it was significantly attenuated by intraperitoneal acute treatment with amitriptyline, gabapentin, tramadol, duloxetine, or carbamazepine but not by diclofenac. The density of PGP-9.5+ nerve fibers was reduced in CAF + STZ mice compared to other groups.Conclusion: This reverse translational study provides a painful DPN mouse model which may help in developing a better understanding of the factors that generate and maintain neuropathic pain and denervation of skin under T2DM and to identify mechanism-based new treatments.
Cytotoxic and Pro-Apoptotic Effects of a Sub-Toxic Concentration of Fluvastatin on OVCAR3 Ovarian Cancer Cells After its Optimized Formulation to Melittin Nano-Conjugates
Authors: Badr-Eldin Shaimaa M. , Alhakamy Nabil A. , Fahmy Usama A. , Ahmed Osama A. A. , Asfour Hani Z. , Althagafi Abdulhamid A. , Aldawsari Hibah M. , Rizg Waleed Y. , Mahdi Wael A. , Alghaith Adel F. , Alshehri Sultan , Caraci Filippo , Caruso Giuseppe 
Published: February 2021

Fluvastatin (FLV) is a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor often used to lower total and low-density lipoprotein (LDL) cholesterol and for the prevention of adverse cardiovascular events. This drug as well as melittin (MEL), the major component of honeybee venom (Apis mellifera), has shown antineoplastic activity, then representing promising approaches for cancer therapy. However, adverse effects related to the use of FLV and MEL have been reported and very few studies have been carried out to obtain an optimized formulation allowing for combining the two drugs and then maximizing the anticancer activity, then minimizing the needed dosage. In the present study, an optimized formulation in terms of minimized particle size and maximized zeta potential was investigated for its cytotoxic potential in human OVCAR3 ovarian cancer cells. FLV-MEL nano-conjugates, containing a sub-toxic concentration of drug, demonstrated an improved cytotoxic potential (IC50 = 2.5 µM), about 18-fold lower, compared to the free drug (IC50 = 45.7 µM). Cell cycle analysis studies demonstrated the significant inhibition of the OVCAR3 cells proliferation exerted by FLV-MEL nano-conjugates compared to all the other treatments, with a higher percentage of cells accumulating on G2/M and pre-G1 phases, paralleled by lower percentage of cells in G0/G1 and S phases. The synergistic antineoplastic activity of FLV and MEL combined in the optimized formula was also showed by the marked pronecrotic and pro-apoptotic activities, the latter mediated by the modulation of BAX/BCL-2 ratio in favor of BAX. Our optimized FLV-MEL formulation might therefore represents a novel path for the development of specific and more effective antineoplastic drugs directed against ovarian cancer.
Dynamic Response of Donor-Derived Cell-Free DNA Following Treatment of Acute Rejection in Kidney Allografts
Authors: Wolf-Doty Theresa K. , Mannon Roslyn B. , Poggio Emilio D. , Hinojosa Randall J. , Hiller David , Bromberg Jonathan S. , Brennan Daniel C. 
Published: February 2021

Key Points

Donor-derived cell-free DNA (dd-cfDNA) changes dynamically after treatment for rejection.dd-cfDNA allows for frequent assessments after episodes of rejection.Persistently elevated dd-cfDNA levels could indicate incomplete recovery of rejection episodes.

Background
The quantification of rejection treatment efficacy has been insufficient using traditional markers due, in part, to the lagging response of serum creatinine and histologic alterations on biopsy specimens. Donor-derived cell-free DNA (dd-cfDNA) is a molecular marker of injury that may assess allograft injury after rejection.

Methods
Retrospective review of the DART study identified 70 patients who had a clinically indicated biopsy, simultaneous dd-cfDNA measurement, and at least one follow-up dd-cfDNA within 3 months post-treatment. Thirty-five patients had no biopsy–proven rejection and no rejection treatment (NR), 16 patients had no biopsy–proven rejection but did receive rejection treatment (CR), 9 patients had diagnosis of ABMR/mixed rejection on biopsy and received rejection treatment (ABMR), and 10 patients had diagnosis of TCMR and received rejection treatment (TCMR). The CR, ABMR, and TCMR groups combined to form a rejection (R) group.

Results
In the R group, median dd-cfDNA values at baseline and 1 month were 0.62% and 0.35% (n=21 pairs, p=0.34), and at baseline and 2-3 months were 0.77% and 0.21% (n=23 pairs, p=0.002). In TCMR, median dd-cfDNA values at baseline and 1 month were 1.13% and 0.37% (n=5 pairs, p=0.63), and at baseline and 2-3 months were 0.25% and 0.12% (n=9 pairs, p=0.004). In ABMR, median dd-cfDNA values at baseline and 1 month were 1.61% and 1.2 % (n=6 pairs, p>0.99), and at baseline and 2-3 months were 3.85% and 1.32% (n=6 pairs, p=0.09). In CR, median dd-cfDNA values at baseline and 1 month were 0.31% and 0.29% (n=10 pairs, p=0.38), and at baseline and 2-3 months were 0.38% and 0.17% (n=8 pairs, p=0.31). Lastly, in NR, median dd-cfDNA values at baseline and 1 month were 0.23% and 0.18% (n=21 pairs, p=0.10), and at baseline and 2-3 months were 0.33% and 0.17% (n=26 pairs, p=0.003). Changes in serum creatinine across 1 month and 2-3 months following rejection were similar.

Conclusions
dd-cfDNA may be a useful dynamic biomarker to assess the health of the kidney allograft following rejection treatment.
Peran Manajemen Sumber Daya Manusia "Sistem Rekrutmen, Seleksi, Kompetensi dan Pelatihan" Terhadap Keunggulan Kompetitif: Literature Review
Authors: Halisa Novia Nour 
Published: February 2021

Globalisasi menimbulkan persaingan yang ketat di berbagai bidang. Agar dapat memenangkan persaingan, perusahaan mulai berlomba–lomba dan dituntut dalam mendapatkan sumber daya manusia yang berkompeten untuk dapat mendukung kemajuan usaha mereka serta dapat bersaing dengan perusahaan lain. Penelitian ini menganalisa pengaruh sistem rekrutmen, seleksi, kompetensi, dan training terhadap kinerja karyawan di perusahaan, mengingat pentingnya peran sumber daya manusia dalam keunggulan kompetitif perusahaan. Tujuan dari penulisan ini adalah mengetahui sejauh mana perkembangan penelitian yang berhubungan dengan topik tersebut. Metode yang digunakan dalam penelitian ini yaitu pendekatan eksploratif dengan mengulas isi atau mengidentifikasi beberapa artikel baik dari jurnal-jurnal nasional maupun internasional. Hasil penelitian dapat diketahui bahwa baik secara simultan maupun parsial membuktikan bahwa sistem rekrutmen, seleksi, pelatihan, dan kompetensi berpengaruh signifikan terhadap keunggulan kompetitif perusahaan. Sehingga manajemen sumber daya manusia berperan penting dalam terwujudnya karyawan yang berkualitas dan mempunyai kinerja optimal.
Rancang Bangun Sistem Seleksi Rekrutmen Karyawan Dan Guru Berbasis Website Pada Sekolah Citra Bangsa Tangerang
Authors: Purwantih Haella , Fuji Zaenab , Amelia Windy , Dwi Rosmawati , Bilqis Hilshie Maulida 
Published: February 2021

Sistem Seleksi Rekrutmen Karyawan dan Guru pada Sekolah Citra Bangsa Tangerang masih bersifat semi manual yaitu pelamar datang langsung ke Sekolah Citra Bangsa Tangerang atau mengirim surat lamaran melalui pos sehingga terjadi penumpukan berkas-berkas data pelamar serta rentan terhadap rusak dan hilangnya data. Untuk itu diperlukan sistem aplikasi berbasis website. Aplikasi ini menggunakan metode pengumpulan data dengan observasi, wawancara dan studi pustaka. Kemudian metode perancangan menggunakan Unified Modeling Language (UML) diantaranya: Use Case diagram, Activity diagram, Sequence diagram, Class diagram. Sedangkan bahasa pemrogramannya adalah PHP (Hypertext Preprocessor) dan Javascript. Untuk database menggunakan Mysql. Selanjutnya metode pengujian/testing menggunakan Black Box Testing. Diharapkan dengan aplikasi berbasis website ini dapat membantu memudahkan pekerjaan admin dan menghasilkan data yang akurat sehingga dapat menunjang aktifitas Sekolah. Selain itu juga memudahkan masyarakat yang berminat melamar pekerjaan di Sekolah Citra Bangsa Tangerang.
Properties dependence of the lightweight alumina products obtained by a semi-dry pressing method on the alumina type
Authors: Martynenko V. V. , Krakhmal Yu. A. , Kushchenko K. I. , Tishina T. G. 
Published: February 2021

Lightweight materials are widely used in industry for thermal insulation of various thermal units. The choice of lightweight material depends on the specific conditions of service. For the lining of high-temperature units operating in reducing environments, alumina lightweight products are used that contain a minimum amount of Fe2O3 impurities and free (unbound in compounds) SiO2.
In JSC “URIR named after A. S. Berezhnoy” a technology of alumina lightweight products of grades KLA-1.1 and KLA-1.3 by a semi-dry pressing method with an application temperature of up to 1550 °C has been developed. These products are made from a mixture of ground and no-milled γ-form alumina of grade 0 and α-form alumina of grade S with additives of pitch coke and chalk.
The work purpose was improvement of the alumina lightweight products technology and search for new alternative raw materials along with the currently used alumina grade S. The properties dependence of alumina lightweight products, obtained by the semi-dry pressing method, on the type of alumina α-form, was investigated.
As a result of the studies, it was found that, for the manufacture of alumina lightweight products of grades KLA-1.1 and KLA-1.3 by the semi-dry pressing method, alumina grades N and NR can be used as an alternative alumina-containing raw material along with alumina grade S. The phase composition of alumina lightweight products of grades KLA-1.1 and KLA-1.3, which are manufactured using alumina grades S, N and NR, was represented mainly by corundum and calcium hexaluminate. The alumina lightweight products, which were manufactured using alumina grades S, N and NR, were characterized by similar high properties and correspond the technical requirements for grades KLA-1.1 and KLA-1.3.
Control of the work quality of chemical and analytical departments of the refractory industry enterprises of Ukraine in 2019
Authors: Birukova E. V. , Varganov V. V. , Konchinko N. N. 
Published: February 2021

Control of the work quality of chemical and analytical departments of the refractory industry enterprises of Ukraine is one of the activity areas of JSC "The URIR named after A. S. Berezhnoy" and helps to increase the competitiveness of products manufactured by enterprises.The comparison of work quality of chemical-analytical units of refractory enterprises (JSC "KDZ", PJSC "Chasovoyarsk Refractory Plant", JSC "Velikoanadol Refractory Plant") and JSC "The URIR named after A. S. Berezhnoy" was carried out. The discrepancy between the average results of chemical analysis in the chemical-analytical unit of refractory enterprises and in the laboratory of chemical-analytical and structural-phase research of JSC "The URIR named after A. S. Berezhnoy" does not exceed the permissible value of γ in terms of SОU-N МPP 77.080-012:2004. The work quality of chemical-analytical units of central refractory laboratories of all the above mentioned refractory enterprises is satisfactory. Recommendations for improving the accuracy of the chemical analysis results in the refractory enterprises laboratories that participated in the tests are not required.
FDI, Trade and Economic Development in Pakistan
Authors: Afzal Muhammad , Ahmad Shoaib 
Published: February 2021

This paper examined the relationship between FDI, imports, exports, terms of trade and investment in Pakistan for the period 1990-2015. Results show that an increase in all these factors will contribute significantly to FDI flows that may help the Pakistan’s economy. FDI has negative and significant impact on GDP. Exports have an insignificant effect that may imply that historically economy had led exports more than the exports led the economy. More important fact is that world economic conditions play a crucial role in the macroeconomic performance. When these conditions are favorable, not only the economy but also the trade grow. Though global financial crisis did not seriously affect Pakistan’s economy, Pakistan faced multifaceted challenges on external and internal fronts notably fight against extremism, energy crisis and uncertain external inflows. There is a need to pay more attention to domestic situation than to look abroad for financial assistance since FDI is not an unmixed blessing.
Low Cost Monitoring Kesehatan Berbasis Internet of Thing
Authors: Hidayanti Nuril , Titisari Dyah 
Published: February 2021

Sistem monitoring pasien di rumah sakit dilakukan secara konvensional dengan mendatangi pasien, kendalanya apabila jumlah tenaga dan fasilitas medis terbatas dengan banyaknya jumlah pasien akan membahayakan pasien yang membutuhkan prioritas penanganan. Tujuan dari penelitian ini adalah mendesain sebuah alat monitoring detak jantung, suhu tubuh, dan respirasi berbasis IOT (parameter detak jantung dan suhu tubuh) dengan tampilan pada web thingspeak dan terdapat notifikasi gmail yang dapat diakses tenaga medis. Kontribusi penelitian ini merancang alat monitoring kesehatan berbasis IOT (Internet of Thing) sehingga dapat dilakukannya pemantauan jarak jauh dengan memanfaatkan web Thingspeak sebagai tampilan hasil penelitian dan memberi notifikasi apabila terdapat nilai tidak normal. Pengambilan data dapat menghasilkan hasil yang akurat diperlukan posisi rileks dari pasien dan kestabilan jaringan wi-fi agar pemantauan tidak terhambat. Penelitian ini menggunakan Sensor suhu DS18B20 merupakan sensor digital dengan 1 jalur data yang diletakkan pada bagian aksila dan pulse sensor (SEN11574) dengan 1 jalur data yang diletakkan pada jari tangan. Hasil penelitian telah dapat dilakukan pengambilan data pada pasien 1 dengan kesalahan rata-rata alat 0,6 untuk parameter detak jantung dan 0,05 untuk parameter suhu tubuh. Pada penelitian ini telah dapat menampilkan data pada web Thingspeak dan mengirimkan notifikasi dengan baik sesuai yang diharapkan peneliti. Penelitian ini juga telah dapat diimplementasikan pada sistem alat monitoring yang sejenis untuk meningkatkan kemudahan pemantauan.
Portable Electrocardiograph Dengan Sadapan Pada Telapak Tangan Dan Kaki
Authors: Linnas Muhammad Syifaul , Sumber Sumber , Tetraputra Prastawa Assalim 
Published: February 2021

Electrocardiograph (ECG) secara rutin dilakukan oleh operator terampil yang terbiasa dengan penempatan masing-masing elektroda pada pasien. Posisi elektroda yang salah dapat menyebabkan kesalahan kritis dalam diagnosis dan perawatan penyakit jantung. Tujuan dari penelitian ini adalah mendesain sebuah Portable Electrocardiograph dengan Sadapan Pada Telapak Tangan dan Kaki. Kontribusi dari penelitian ini adalah memudahkan orang awam dalam bidang kesehatan dalam hal penggunaan Electrocardiograph. Penelitian ini juga bertujuan mendesain Electrocardiograph yang cukup terjangkau bagi puskesmas/pusat-pusat pelayanan medis di daerah. Agar desain ini dapat memudahkan dalam metode penggunaan alat, maka dibuatlah alat Electrocardiograph (ECG) dengan elektroda pad yang akan diletakkan pada telapak tangan dan telapak kaki yang telah di berikan tanda pada elektroda tersebut. Electrocardiograph (ECG) menggunakan desain High Pass Filter (Pasif 20dB ditambah Non Inverting Amplifier, Low Pass Filter (LPF) 40dB, dan notch filter yang akan ditampilkan pada layar monitor Personal Computer (PC). Dari hasil sadapan beberapa responden, terlihat hasil tampilan yang menyerupai/mendekati sinyal Electrocardiograph (ECG) sebenarnya. Kekurangan dari modul ini jika tidak adanya grounding yang baik dari power suply maka akan terjadi noise pada hasil sinyal yang akan ditampilkan. Hasil penelitian ini dapat di implementasikan pada Electrocardiograph (ECG) konvensional untuk meningkatkan kemudahan dalam hal penggunaan alat.
PERAN PENYULUH PERTANIAN DALAM MENDUKUNG KETAHANAN PANGAN PADA SAAT WABAH PANDEMI COVID-19
Authors: Sudarmansyah Sudarmansyah , Ruswendi Ruswendi , Ishak Andi , Fauzi Emlan , Yuliasari Shannora , Firison Jhon 
Published: February 2021

Peran Penyuluh Pertanian sangat ditentukan oleh situasi yang dihadapi di lapangan. Penelitian ini bertujuan untuk mengetahui peran Penyuluh Pertanian dalam mendukung ketahanan pangan pada saat wabah pandemi covid 19. Data dikumpulkan dari hasil penelusuran informasi berita media online sejak bulan Maret – Juli 2020. Informasi yang dikumpulkan berupa konten kegiatan penyuluhan yang terkait dengan ketahanan pangan dari sumber media online yaitu situs berita online dan situs pemerintah tentang peran penyuluh dalam mendukung ketahanan pangan pada saat wabah pandemi covid 19. Informasi yang diperoleh dianalisis secara deskriptif. Hasil analisis menunjukan bahwa peran penyuluh dalam melakukan kegiatan Penyuluhan pada saat wabah pandemi covid 19 yaitu peran penyuluh sebagai pendukung kebijakan program pemerintah, motivator bagi petani dan fasilitator dalam mendukung kegiatan usahatani. Secara khusus, peran penyuluh lebih banyak di arahkan pada upaya dalam rangka mempertahankan ketahanan pangan (71.15%) terutama untuk komoditas padi yakni sebesar 54 % dengan cara metode penyuluhan langsung menggunakan protokol covid 19 sebanyak 79 %. Kata kunci : peran penyuluh, ketahanan pangan, pandemi covid 19, media online.