bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological well-being of palliative care professionals: Who cares?
Authors: Moreno-Milan Beatriz , Breitbart Bill , Herreros Benjamin , Olaciregui Dague Karmele , Coca Pereira María Cristina 
Published: April 2021

AbstractBackgroundTraditionally, the psychological well-being of healthcare workers has been taken for granted — it has even been considered a part of the requirements that were demanded of them. When these professionals have experienced suffering and psychological depletion, they have been held accountable for this suffering, adopting an individualistic and reductionist viewpoint focused only on the professional. This approach has become obsolete due to its proven ineffectiveness, especially from an ethics of responsibility and organization viewpoint.ContextThe psychological well-being of the healthcare worker (and its opposites: suffering, exhaustion, and disenchantment) is advantageous to the professional's commitment to the institution, to their work performance, and to their personal life.ObjectiveThe objective of this paper is to reflect on the psychological suffering of the palliative care professional.MethodWe will reflect on the three levels of responsibility that influence such suffering (micro-meso-macro-ethical; worker-environment-institution).ResultsWe will propose a global strategy for the care of psychological well-being supported by scientific evidence and key references.Significance of resultsWe conclude with some contributions on what we have learned and still have to learn on this topic.
Wearing the Pants(suit)? Gendered Leadership Styles, Partisanship, and Candidate Evaluation in the 2016 U.S. Election
Authors: Bernhard Rachel 
Published: April 2021

AbstractDo messages that evoke a gendered leadership style affect attitudes toward well-known candidates? If so, among what sorts of voters? I show that voters’ evaluations of national politicians, including Hillary Clinton, can be influenced by presenting candidates as stereotypically masculine or feminine leaders. In two survey experiments of California registered voters (n= 1,800 each) conducted at the height of the 2016 presidential election campaign, I find that, on average, voters seemed to prefer both male and female politicians more when they were described as having feminine leadership styles. However, clear heterogeneous treatment effects occurred: Democrats, liberals, and women from all parties evaluated politicians more favorably when they were described as feminine; Republicans, conservatives, and voters for Donald Trump evaluated the same candidates less favorably when described as feminine. The findings have implications for scholarship that links gender stereotyping, partisanship, and ideology to voter behavior.
Pilot study of a group worry intervention for recent onset psychosis
Authors: Mackintosh Teal , Lean Melanie , Hardy Kate 
Published: April 2021

Abstract
Worry is common among individuals with psychosis and has been found to be a causal factor in the development of paranoia. Previous research has shown that a cognitive behavioural therapy protocol targeting worry helps to reduce persecutory delusions and associated distress in a population experiencing longstanding psychotic symptoms. However, there has yet to be a published adaptation of the protocol for individuals experiencing a recent onset of psychosis. The current study aims to examine the feasibility of adapting the worry intervention for recent onset psychosis in a group setting. Six young adults with a recent onset of psychosis, aged 18–32 years, participated in a pilot study of an 8-week group intervention covering cognitive behavioural strategies for managing worry, including worry periods, worry postponement techniques, mindfulness and relaxation, and problem solving. Pre- and post-intervention data were collected on worry, anxiety, depressive symptoms, psychotic symptoms, and perceived recovery from psychosis. In addition, qualitative feedback from group members was gathered during a post-intervention focus group. Feasibility of the group appeared promising, despite high participant attrition. All components of the intervention were successfully implemented, and group members provided positive feedback regarding acceptability of the group. Contrary to prediction, there was not a consistent decrease in worry from pre- to post-intervention. Findings from secondary symptom measures were mixed and may have been related to participants’ subjective experience of the group. Specifically, participants who experienced high levels of group cohesion seemed to benefit more from the intervention.

Key learning aims

(1)
To gain awareness of the gaps in treatment for early psychosis.

(2)
To understand the role of worry in psychosis.

(3)
To learn about the feasibility of implementing a group worry intervention for recent onset psychosis.

(4)
To consider the impact of group cohesion and symptom severity on treatment engagement.
Neonatal nicotine exposure changes insulin status in fat depots: sex-related differences
Authors: Rodrigues Vanessa da Silva Tavares , Miranda Rosiane A. , Soares Patricia Novaes , Peixoto Thamara Cherem , de Oliveira Elaine , Manhães Alex C. , de Moura Egberto Gaspar , Lisboa Patrícia Cristina 
Published: April 2021

AbstractNicotine is the main psychoactive substance present in cigarette smoke that is transferred to the baby by breast milk. In rats, maternal nicotine exposure during breastfeeding induces obesogenesis and hormone dysfunctions in adult male offspring. As glucocorticoid (GC), insulin, and vitamin D change both adipogenesis and lipogenesis processes, we assessed parameters related to metabolism and action of these hormones in visceral and subcutaneous adipose tissues (VAT and SAT) of adult male and female rats in a model of neonatal nicotine exposure. At postnatal (PN) day 2, dams were kept with six pups (three per sex) and divided into nicotine and control groups for implantation of osmotic minipumps that released 6 mg/kg nicotine or saline, respectively. At PN180, fat mass, hormone levels, and protein contents of biomarkers of the GC activation and receptor (11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor alpha), insulin signaling pathway [insulin receptor beta (IRβ), phosphorylated insulin receptor substrate 1, insulin receptor substrate 1 (IRS1), phosphorylated serine/threonine kinase (pAKT), serine/threonine kinase, glucose transporter type 4 (GLUT4)], and vitamin D activation and receptor (1α-hydroxylase and vitamin D receptor) were evaluated. While nicotine-exposed males showed increased fat mass, hypercorticosteronemia, hyperinsulinemia, and higher 25-hydroxyvitamin D, these alterations were not observed in nicotine-exposed females. Nicotine-exposed males only showed lower IRS1 in VAT, while the females had hyperglycemia, higher pAKT in VAT, while lower IRβ, IRS1, and GLUT4 in SAT. Parameters related to metabolism and action of GC and vitamin D were unaltered in both sexes. We evidence that exposure exclusively to nicotine during breastfeeding affects the hormone status and fat depots of the adult progeny in a sex-dependent manner.
Evidence for the Scarr–Rowe Effect on Genetic Expressivity in the Health and Retirement Study
Authors: Woodley of Menie Michael A. , Peñaherrera-Aguirre Mateo , Dunkel Curtis S. , Sarraf Matthew A. 
Published: April 2021

AbstractThe Scarr–Rowe effect is a gene × environment interaction, which is characterized by a negative association between exposure to low socioeconomic status (SES) environments and the additive heritability of cognitive ability. Utilizing a polygenic score for educational attainment (EA3), it was found that the two-way interaction between EA3 and parental educational attainment (EA; used as a proxy for parental SES) was a significant positive predictor of participants’ composite cognitive ability (IQ) score (β = .018, SE = .008, p = .028) after controlling hierarchically for the direct effects of (population-stratification-controlled) EA3, parental EA, and 20 distinct interaction terms (10 involving the interactions between the principal components [PCs] and EA3, and 10 involving the interaction between the PCs and parental EA). The presence of this interaction is consistent with the Scarr–Rowe effect, as the expressivity of EA3 on cognitive ability increases with increasing parental EA. No statistically significant sex differences in the effect magnitudes were found, although the effect was significantly present in the female but not male sample.
Environmental cues affecting horseweed (Conyza canadensis) growth types and their sensitivity to glyphosate
Authors: Schramski John A. , Sprague Christy L. , Patterson Eric L. 
Published: April 2021

AbstractHorseweed [Conyza canadensis(L.) Cronquist] is a facultative winter annual weed that can emerge from March to November in Michigan. Fall-emergingC. canadensisoverwinters as a rosette, while spring-emergingC. canadensisskips the rosette stage and immediately grows upright upon emergence. In Michigan, primary emergence recently shifted from fall to spring/summer and therefore from a rosette to an upright growth type. Growth chamber experiments were conducted to determine (1) whether bothC. canadensisgrowth types could originate from a single parent and (2) whether common environmental cues can influence growth type. Variations in temperature, photoperiod, competition, shading, and soil moisture only resulted in the rosette growth type in fourC. canadensispopulations originating from seed collected from a single parent of the upright growth type. However, a vernalization period of 4 wk following water imbibition, but before germination, resulted in the upright growth type. Dose–response experiments were conducted to determine whether glyphosate sensitivity differed betweenC. canadensisgrowth types generated from a single parent of the upright growth type. Upright-typeC. canadensisfrom known glyphosate-resistant populations ISB-18 and MSU-18 were 4- and 3-fold less sensitive to glyphosate than their rosette siblings, respectively. Interestingly, differences in glyphosate sensitivity were not observed between growth types from the susceptible population. These results suggest that whileC. canadensispopulations shift from winter to summer annual life cycles, concurrent increases in glyphosate resistance could occur.
Global Microphysical Sensitivity of Superparameterized Precipitation Extremes
Authors: Charn Alexander B. , Collins William D. , Parishani Hossein , Risser Mark D. 
Published: April 2021

AbstractA recent study found statistically significant differences in extreme precipitation distributions over the contiguous United States (CONUS) when changing the microphysics scheme in a superparameterized global climate model. Here, we repeat the analysis globally and similarly find that differences are widespread when varying the number of predicted moments in the microphysics parameterization, but not when comparing variants of the double‐moment scheme. However, contrary to the previous study in which differences largely disappeared over CONUS when 5‐day simulations were conducted, we found that the signal in these shorter integrations remains within the tropics, implying a direct local effect of microphysics on precipitation extremes in these regions. The effect on precipitation is traced back to changes in vertical velocity profiles changes that are then amplified in the climatological simulations compared to the 5‐day ones. Finally, the superparameterized extremes, regardless of the microphysics scheme, are shown to be larger than those from the Global Precipitation Climatology Project One‐Degree Daily data set and generally smaller than those from the Tropical Rainfall Measuring Mission 3B42 data set.
Bursty Ion Escape Fluxes at Mars
Authors: Dubinin E. , Fraenz M. , Pätzold M. , Tellmann S. , Woch J. , McFadden J. , Zelenyi L. 
Published: April 2021

AbstractBased on the Mars Atmosphere and Volatile Evolution measurements we have observed cases when the fluxes of oxygen ions escaping the Martian ionosphere exceed their median values by more than a factor of 100. In the Martian tail very high fluxes of the more energetic (E > 30 eV) oxygen ions fill the plasma sheet which then becomes much broader than under conditions with median values of ion fluxes. We have analyzed the occurrence of such events in the upper ionosphere near the terminator plane, which is the main source region of ions in the plasma tail. The maximum values of fluxes of oxygen ions with E > 30 eV were observed mostly in the hemisphere where the motional electric field imposed by the solar wind is directed outward from the planet. Although high values of the solar wind dynamic pressure and (or) the motional electric field are favorable for the observation of the extreme values of ion fluxes with E > 30 eV, there must also be other factors which initiate these events. In particular, we found a close relation of the maximum ion fluxes with the values of the simultaneously measured fluxes of solar wind penetrating into the upper ionosphere. Direct interaction of both plasmas might be a critical factor for the strong growth of the oxygen ion escape. Very high fluxes of the low‐energy oxygen ions (E < 30 eV) are often related with ion “clouds” with anomalously large number density observed in the upper ionosphere.
Complicated Lithospheric Structure Beneath the Contiguous US Revealed by Teleseismic S‐Reflections
Authors: Liu Tianze , Shearer Peter M. 
Published: April 2021

AbstractLithospheric discontinuities, including the lithosphere‐asthenosphere boundary (LAB) and the enigmatic mid‐lithospheric discontinuities (MLDs), hold important clues about the structure and evolution of tectonic plates. However, P‐ and S‐receiver‐function (PRF and SRF) techniques, two traditional techniques to image Earth's deep discontinuities, have some shortcomings in imaging lithosphere discontinuities. Here, we propose a new method using reflections generated by teleseismic S waves (hereafter S‐reflections) to image lithospheric discontinuities, which are less affected by multiple phases than PRFs and have better depth resolution than SRFs. We apply this method to the data collected by the Transportable Array and other regional seismic networks and obtain new high‐resolution images of the lithosphere below the contiguous US. Beneath the tectonically active Western US, we observe a negative polarity reflector (NPR) in the depth range of 60–110 km, with greatly varying amplitude and depth, which correlates with active tectonic processes. We interpret this feature as the LAB below the Western US. Beneath the tectonically stable Central and Eastern US, we observe two NPRs in the depth ranges of 60–100 km and 100–150 km, whose amplitude and depth also vary significantly, and which appear to correlate with past tectonic processes. We interpret these features as MLDs below the Central and Eastern US. Our results show reasonable agreement with results from PRFs, which have similar depth resolution, suggesting the possibility of joint inversion of S‐reflections and PRFs to constrain the properties of lithospheric discontinuities.
Syn‐Orogenic Exhumation of High‐P Units by Upward Extrusion in an Accretionary Wedge: Insights From the Eastern Elba Nappe Stack (Northern Apennines, Italy)
Authors: Ryan E. , Papeschi S. , Viola G. , Musumeci G. , Mazzarini F. , Torgersen E. , Sørensen B. E. , Ganerød M. 
Published: April 2021

AbstractThe E‐vergent Northern Apennines formed by Oligocene‐Miocene convergence and westward subduction of Adria beneath Europe. Extension ensued in the Mid‐Late Miocene reflecting lower plate roll‐back and causing opening of the back‐arc Northern Tyrrhenian Sea. Post‐orogenic extension is commonly advocated as the main driver of the exhumation of the belt's inner domain high‐pressure/low‐temperature (HP‐LT) rock units. The Acquadolce Subunit of the Eastern Elba nappe stack contains HP‐LT rocks recording peak blueschist conditions of 1.5–1.8 GPa at 320°C–370°C loosely dated to the Oligocene‐Early Miocene. It is sandwiched by two Late Miocene, out‐of‐sequence top‐to‐the E thrusts between Jurassic LP serpentinites on top and HT–LP contact metamorphosed marbles at its base. We document widespread W‐verging ductile asymmetries within the Acquadolce Subunit, which correspond to top‐to‐the W extensional shearing for the nappe stack current orientation. This allowed for early syn‐orogenic exhumation from blueschist‐ to greenschist‐facies conditions, wherein coeval W‐directed extension at the top of the exhuming units acted synchronously with E‐directed thrusting at their base causing exhumation by extrusion in an overall contractional setting. The basal, E‐vergent thrusting is, however, challenging to document as the wedge has since been reworked by Late Miocene, E‐verging compressive tectonics, contact metamorphism, and later extension, obliterating much of the evidence supporting exhumation by extrusion during the early stages of wedge build‐up. Syn‐orogenic exhumation by extrusion from deep structural levels within the orogenic wedge is a viable mechanism to account for other exhumed HP‐LT units in the inner part of the belt.
How to turn up the heat on the cold immune microenvironment of metastatic prostate cancer
Authors: Stultz Jacob , Fong Lawrence 
Published: April 2021

Abstract
Background
Advanced prostate cancer remains one of the most common and deadly cancers, despite advances in treatment options. Immunotherapy has provided little benefit to a majority of patients, largely due to the immunosuppressive tumor microenvironment that gives rise to inherently “cold tumors”. In this review, we discuss the immunopathology of the prostate tumor microenvironment, strategies for treating prostate cancer with immunotherapies, and a perspective on potential approaches to enhancing the efficacy of immunotherapies.

Methods
Databases, including PubMed, Google Scholar, and Cochrane, were searched for articles relevant to the immunology of prostate cancer. We discuss the impact of different types of treatments on the immune system, and potential mechanisms through which prostate cancer evades the immune system.

Results
The tumor microenvironment associated with prostate cancer is highly immunosuppressive due to (1) the function of regulatory T cells, tumor-associated macrophages, and myeloid-derived suppressor cells (MDSCs), (2) the cytokine milieu secreted by tumor stromal cells and fibroblasts, and (3) the production of adenosine via prostatic acid phosphatase. Both adenosine and tumor growth factor beta (TGF-beta) serve as potent immunosuppressive molecules that could also represent potential therapeutic targets. While there have been many immunotherapy trials in prostate cancer, the majority of these trials have targeted a single immunosuppressive mechanism resulting in limited clinical efficacy. Future approaches will require the integration of improved patient selection as well as use of combination therapies to address multiple mechanisms of resistance.

Conclusion
Prostate cancer inherently gives rise to multiple immunosuppressive mechanisms that have been difficult to overcome with any one immunotherapeutic approach. Enhancing the clinical activity of immunotherapies will require strategic combinations of multiple therapies to address the emerging mechanisms of tumor immune resistance.
Microbiome assembly for sulfonamide subsistence and the transfer of genetic determinants
Authors: Deng Yu , Huang Yue , Che You , Yang Yu , Yin Xiaole , Yan Aixin , Dai Lei , Liu Yang-Yu , Polz Martin , Zhang Tong 
Published: April 2021

Abstract
Antibiotic subsistence in bacteria represents an alternative resistance machinery, while paradoxically, it is also a cure for environmental resistance. Antibiotic-subsisting bacteria can detoxify antibiotic-polluted environments and prevent the development of antibiotic resistance in environments. However, progress toward efficient in situ engineering of antibiotic-subsisting bacteria is hindered by the lack of mechanistic and predictive understanding of the assembly of the functioning microbiome. By top–down manipulation of wastewater microbiomes using sulfadiazine as the single limiting source, we monitored the ecological selection process that forces the wastewater microbiome to perform efficient sulfadiazine subsistence. We found that the community-level assembly selects for the same three families rising to prominence across different initial pools of microbiomes. We further analyzed the assembly patterns using a linear model. Detailed inspections of the sulfonamide metabolic gene clusters in individual genomes of isolates and assembled metagenomes reveal limited transfer potential beyond the boundaries of the Micrococcaceae lineage. Our results open up new possibilities for engineering specialist bacteria for environmental applications.
Neutrophil to lymphocyte ratio influences impact of steroids on efficacy of immune checkpoint inhibitors in lung cancer brain metastases
Authors: Lauko Adam , Thapa Bicky , Sharma Mayur , Muhsen Baha’eddin , Barnett Addison , Rauf Yasmeen , Borghei-Razavi Hamid , Tatineni Vineeth , Patil Pradnya , Mohammadi Alireza , Chao Samuel , Murphy Erin S. , Angelov Lilyana , Suh John , Barnett Gene H. , Nowacki Amy S. , Pennell Nathan , Ahluwalia Manmeet S. 
Published: April 2021

AbstractSteroids are often utilized to manage patients with non-small cell lung cancer brain metastases (NSCLCBM). Steroids and elevated neutrophil-to-lymphocyte ratio (NLR) have been associated with decreased overall survival (OS) in patients treated with immune checkpoint inhibitors (ICI). We retrospectively investigated patients treated with ICI after the diagnosis of NSCLCBM at a single tertiary care institution examing the impact of steroids and NLR. Overall survival (OS) and intracranial progression-free survival (PFS) were analyzed. 171 patients treated with ICI for NSCLCBM were included. Thirty-six received steroids within 30 days of the start of ICI, and 53 patients had an NLR ≥ 5 before the start of ICI. Upfront steroids was associated with decreased OS on multivariable analysis (median OS 10.5 vs. 17.9 months, p = .03) and intracranial PFS (5.0 vs. 8.7 months, p = .045). NLR ≥ 5 was indicative of worse OS (10.5 vs. 18.4 months, p = .04) but not intracranial PFS (7.2 vs. 7.7 months, p = .61). When NLR and upfront steroids are modeled together, there is a strong interaction (p = .0008) indicating that the impact of steroids depended on the patient’s NLR. In a subgroup analysis, only in patients with NLR < 4 was there a significant difference in OS with upfront steroids (26.1 vs. 15.6 months, p = .032). The impact of steroids on the efficacy of ICI in patients with NSCLCBM is dependent on the patient's NLR underscoring its importance in these patients. Patients with a low NLR, steroid use decreases the efficacy of ICI. These results can inform clinicians about the impact of steroids in patients treated with ICI.