bluuebunny/crossref_metadata_2025_split huggingface dataset:
An automated approach to determine antibody endpoint titers for COVID-19 by an enzyme-linked immunosorbent assay
Authors: Ho A.D. , Verkerke H. , Allen J.W. , Saeedi B.J. , Boyer D. , Owens J. , Shin S. , Horwath M. , Patel K. , Paul A. , Wu S.-C. , Chonat S. , Zerra P. , Lough C. , Roback J.D. , Neish A. , Josephson C.D. , Arthur C.M. , Stowell S.R. 
Published: April 2021

Abstract
While a variety of therapeutic options continue to emerge for COVID-19 treatment, convalescent plasma (CP) has been used as a possible treatment option early in the pandemic. One of the most significant challenges with CP therapy, however, both when defining its efficacy and implementing its approach clinically, is accurately and efficiently characterizing an otherwise heterogenous therapeutic treatment. Given current limitations, our goal is to leverage a SARS antibody testing platform with a newly developed automated endpoint titer analysis program to rapidly define SARS-CoV-2 antibody levels in CP donors and hospitalized patients. A newly developed antibody detection platform was used to perform a serial dilution enzyme-linked immunosorbent assay (ELISA) for immunoglobulin (Ig)G, IgM, and IgA SARS-CoV-2 antibodies. Data were then analyzed using commercially available software, GraphPad Prism, or a newly developed program developed in Python called TiterScape, to analyze endpoint titers. Endpoint titer calculations and analysis times were then compared between the two analysis approaches. Serial dilution analysis of SARS-CoV-2 antibody levels revealed a high level of heterogeneity between individuals. Commercial platform analysis required significant time for manual data input and extrapolated endpoint titer values when the last serial dilution was above the endpoint cutoff, occasionally producing erroneously high results. By contrast, TiterScape processed 1008 samples for endpoint titer results in roughly 14 minutes compared with the 8 hours required for the commercial software program analysis. Equally important, results generated by TiterScape and Prism were highly similar, with differences averaging 1.26 ± 0.2 percent (mean ± SD). The pandemic has created unprecedented challenges when seeking to accurately test large numbers of individuals for SARS-CoV-2 antibody levels with a rapid turnaround time. ELISA platforms capable of serial dilution analysis coupled with a highly flexible software interface may provide a useful tool when seeking to define endpoint titers in a high-throughput manner.
Immunohematology

2021;37:33–43.
Impacto de la COVID-19 en la producción, empleo y digitalización de empresas en Guanajuato: una primera aproximación
Authors: Martínez Martínez Adriana 
Published: April 2021

La Crisis del Gran Confinamiento provocada por la pandemia de la COVID 19 está provocando estragos económicos importantes como la caída de la producción y la pérdida de empleos. El objetivo de este artículo analizar el impacto de la emergencia sanitaria en el empleo y la producción, así como las estrategias de digitalización adoptadas por empresas localizadas en el estado de Guanajuato con la finalidad de tener una primera aproximación en el estudio de este fenómeno.
Método: Se llevó a cabo una investigación cuantitativa. En la primera etapa se recopiló y analizó información estadística para el período enero de 2019 a octubre de 2020 sobre la producción y el empleo en México. En la segunda etapa se diseñó y aplicó a empresas localizadas en Guanajuato, de manera digital, la Encuesta sobre el Impacto en la Actividad Empresarial (esiae) de la COVID-19; se utilizó el muestreo por conveniencia.
Resultados: En cuanto a México, los datos estadísticos muestran una caída significativa tanto en la producción como en el empleo. Y esto es coincidente con los resultados arrojados por la esiae, las empresas encuestadas presentaron una disminución significativa tanto en sus ingresos como en el número de empleos, con excepción de las que pertenecen a los sectores que realizan actividades clasificadas como esenciales. Entre las estrategias de digitalización que han puesto en práctica, se encuentra el home office, la comercialización de sus productos o servicios a través de plataformas de Marketplace.
Discusión: El supuesto hipotético que se tenía al principio de que la pandemia está acelerando la digitalización y de que las empresas necesitarán contratar especialistas para implementarla no se cumplió. Los puestos que las empresas han creado son tradicionales y las estrategias de digitalización implementadas están enfocadas al home-office y la comercialización. Los resultados obtenidos en la encuesta no se pueden generalizar; sin embargo, apoyan el planteamiento de la siguiente hipótesis de trabajo: las estrategias de digitalización y el tipo de empleos requeridos está en función tanto del sector de pertenencia así como de la complejidad tecnológica del producto o servicio brindado. Para futuras investigaciones se recomienda ampliar la muestra y aplicar la encuesta por sectores; asimismo es necesario la realización de estudios de caso que permitan una mayor comprensión de este fenómeno.
Seroprevalencia y seguimiento de anticuerpos IgG contra SARS-CoV-2 en personal del Laboratorio Estatal de Salud Pública de Guanajuato LaESaP
Authors: Alvarado Orozco María , Rangel Aguilera Juan Manuel , Barba Hernández Beatriz Adriana , García Baeza Lorena Carina , Sánchez Navarro María del Rosario 
Published: April 2021

El sector salud, al frente de la actual pandemia, está altamente expuesto al contagio de COVID- 19. Dada la variada sintomatología que presenta la enfermedad y ante la escasez de estudios de seroprevalencia en unidades de diagnóstico por Laboratorio, surge la necesidad de estudiar la presencia y comportamiento de los anticuerpos anti SARS-CoV-2 en el personal del Laboratorio Estatal de Salud Pública de Guanajuato (LaESaP), lugar donde se efectúa el diagnóstico molecular de COVID-19 en Guanajuato, desde marzo de 2020. Este estudio pretende estimar la seroprevalencia de anticuerpos IgG anti SARS-CoV-2 en sus trabajadores, así como su permanencia tras un periodo de 5 meses.
Método: Se recolectaron las muestras sanguíneas de 100 trabajadores pertenecientes al LaESaP, que representan la totalidad de los trabajadores que mantuvieron sus actividades laborales desde marzo de 2020 y se analizaron mediante inmunoanálisis quimioluminiscente de micropartículas (CMIA), para la detección cualitativa de anticuerpos IgG frente al virus del SARS-CoV-2.
Resultados: Se encontró una seroprevalencia del 6%, sin embargo, solo el 67% conservó un título de anticuerpos positivo después de 5 meses. No se establecieron correlaciones en los títulos de anticuerpos por género o sintomatología. Los 4 trabajadores con antecedentes de prueba rRT-PCR positiva presentaron anticuerpos al inicio del estudio, así como 2 trabajadores sin antecedente de prueba rRT-PCR, considerados como asintomáticos.
Discusión: Se observó una seroprevalencia baja en el personal de laboratorio en comparación con otros estudios realizados a personal de salud. Lo anterior puede deberse al adecuado uso de equipo de protección personal, buenas prácticas de laboratorio e implementación de medidas de contención dentro de la institución.
Analisis Penentuan Pendapatan Industri Kecil Batik (Desa Pakandangan Barat Kabupaten Sumenep)
Authors: Rahman Fathur , Boedinrocminarmi Arfida , Sudarti Sudarti 
Published: April 2021

Economic growth should be directed in order to increase incomes and overcome economic disparities and social inequalities and also supported by an increase in productivity and efficiency and quality of human resources. Batik industry is one branch of the clothing and leather industry. One of the branches would observed by the author is a small batik industry, because batik is a traditional folk craft, which is one characteristic of Indonesian country and leather clothing industry branches that have a level of development prospective. This study aims to find out the factors wich affect the income of Small Batik Industry at West Pakandangan Village. Bluto sub district, Sumenep districts This study uses multiple linier regression analysis with primary data. The result show that the variable of capital (X1)significant positive effect of 0,000, labor (X2) significant positive effect of 0,001, total production (X3) significant positive effect of 0,055 and pattern share(X4) significant positive effect of 0,000 has simultaneously positive effect and significant to income. For individual, capital variable has no effect and significant at the income of Small Batik Industry at West Pakandangan Village. Bluto sub district, Sumenep districts
Evaluating the effect of the temporal intra-oral skeletal anchorage device (TISADs) for facilitating the anchorage reinforcement: A meta-analysis and systematic review
Authors: Amiri Ali , Khosravi Setareh , Torabi Shiva , Golshekan Hadi , Qi Fan 
Published: April 2021

Objective: In this meta-analysis and systematic review, we aimed to evaluate the effects of the TISADs to facilitates anchorage reinforcement.
Methods: PubMed, Cochrane Library, Embase, ISI, Scopus, Web of Science, LILACS, BBO, OpenGrey, and Google Scholar, were used from the electronic databases until 2020 perform systematic literature. Two reviewers extracted data blindly and independently from various abstracts as well as full texts of articles they considered for data extraction. Using the Cochrane collaboration's tool, we evaluated the publications' quality. Then, we computed the mean difference of TISADs and conventional anchorage groups with a confidence interval (CI) of 95%, restricted maximum likelihood (REML), and random effect model of the mesial movement of molars and their tipping. Moreover, we employed Stata/MP 16 that has been considered the most rapid version of Stata for evaluating meta-analysis.
Results: According to our electronic searches, 134 topics and abstracts with potential relevance were identified according to the research design. Finally, five publications matched the required inclusion criteria of the study. In addition, the Cochrane collaboration instrument exhibited all studies with low to moderate biases. Also, the mean difference of mesial molar movement showed less anchorage loss in the TISADs group vs. the controls, and a significant difference between these two groups (MD= -1.74 with a CI of 95%, -2.76, -0.71. P = 0.00).
Conclusions: TISADs can reduce treatment time, and TISADs are more effective in enables the anchorage than other methods and higher tipping in the TISADs.
Pengaruh Umur Perusahaan, Profitabilitas Dan Leverage Terhadap Pengungkapan Tanggung Jawab Sosial Perusahaan Pada Perusahaan Sektor Manufaktur
Authors: Bangun Nurainun , Diana Lani 
Published: April 2021

Tujuan dari penelitian ini adalah untuk menganalisis pengaruh umur perusahaan,profitabilitas dan leverage terhadap pengungkapan tanggung jawab sosial perusahaansecara simultan dan parsial. Populasi dalam penelitian ini adalah perusahaan sektormanufaktur yang terdaftar di Bursa Efek Indonesia pada tahun 2014-2016. Sampel dalam penelitian ini berjumlah 61 perusahaan. Data sekunder diperoleh dengan mempelajari laporan keuangan dan laporan tahunan perusahaan. Data yang diperoleh kemudian diolah dengan menggunakan software SPSS version 21 for Windows. Hasil penelitian menunjukkan bahwa umur perusahaan, profitabilitas dan leverage memiliki pengaruh secara simultan terhadap pengungkapan tanggung jawab sosial perusahaan. Pengujian secara parsial menunjukkan umur perusahaan dan profitabilitas memiliki pengaruh positif terhadap pengungkapan tanggung jawab sosial perusahaan, sedangkan leverage tidak memiliki pengaruh terhadap pengungkapan tanggung jawab sosial perusahaan.
KAJIAN NILAI EKONOMIS DAN DAMPAK SOSIAL KEBERADAAN EKOSISTEM MANGROVE TERHADAP MASYARAKAT PESISIR
Authors: A. Samad Agus Putra , Agustina Pitri , Herri Mus 
Published: April 2021

Langsa merupakan salah satu kota pesisir Aceh yang memiliki kawasan mangrove yang sangat potensial. Kota ini memiliki panjang garis pantai 16 km dengan luas kawasan mangrove sebesar 7.837 Ha. Keberadaan mangrove di wilayah ini menjadi aset strategis untuk dikembangkan menjadi basis kegiatan ekonomi untuk memakmurkan masyarakat dan meningkatkan pendapatan asli daerah. Tujuan utama penelitian ini adalah untuk melestarikan potensi sumberdaya ekosistem mangrove yang ada di Kota Langsa agar dapat memberikan fungsi ekologis dan ekonomis secara berkesinambungan kepada masyarakat disekitarnya. Kajian ini dilakukan menggunakan metode survei, analisa laboratorium dan observasi lapangan. Hasil pengamatan terhadap komposisi jenis tumbuhan yang terdapat di ekosistem mangrove menunjukkan 8 jenis tumbuhan mangrove yaitu: jenis Avicennia lanata, Avicennia marina, Bruguiera gymnorrhiza, Bruguiera parviflora, Rhizophora apiculata, Rhizophora mucronata, Sonneratia Caseolaris dan Xylocarpus granatum. Nilai rata-rata parameter kualitas air di ekosistem mangrove secara beturut-turut adalah DO (6.3 ppm),salinitas (27 ‰), pH tanah dasar (6.0), pH tanah permukaan (5.08), pH air (7.33), suhu (30 oC) dan kecerahan (5 m). Perhitungan terhadap nilai manfaat ekosistem mangrove meliputi: 1) Nilai manfaat langsung perikanan tangkap: Rp. 8.710.000.000 per tahun, 2) Nilai manfaat budidaya tambak: Rp. 93.940.000.000,- per tahun, 3) Nilai penahan abrasi dan banjir: Rp. 300.000.000,- per hektar per tahun, 4) Nilai sebagai penyediaan unsur hara: Rp. 28.634.000,- per tahun, 5) Nilai manfaat pilihan: Rp. 210.000.000,- per tahun dan 6) Nilai manfaat keberadaan: Rp. 1.464.493.000,- per tahun. Nilai keberadaan ekosistem mangrove yang dinilai adalah Nilai Keaslian = 70 % (lebih dari asli), Nilai Keindahan Alam = 74 % (lebih dari indah), Nilai Kenyamanan = 66% (kondisi lebih dari nyaman), dan Nilai Aspirasi masyarakat = 98 % (sangat didukung masyarakat). Alternatif pengelolaan dan pemanfaatan ekosistem mangrove yang diperkirakan cocok secara ekonomi dan ekologis terdiri dari beberapa kegiatan pilihan yaitu budidaya ikan, udang, tiram dan kepiting, budidaya ikan kerapu dan kakap, pengolahan buah dan daun mangrove, dan pengembangan obyek wisata.
RANCANG BANGUN SISTEM INFORMASI SOFTWARE POINT OF SALE (POS) DENGAN METODE WATERFALL BERBASIS WEB
Authors: Nugraha Putu Gede Surya Cipta 
Published: April 2021

Pada era industri 4.0 saat ini peranan sistem informasi sangat penting dalam memperbaiki arus bisnis suatu perusahaan ataupun yang berwirausaha. POS (Point of sale) merupakan salah satu bidang penerapan sistem informasi yang berkembang dengan pesat. Sistem pencatatan manual membutuhkan waktu yang lama sehingga berjalan tidak efektif, selain itu juga ada kemungkinan terjadi kesalahan informasi, kesalahan penulisan dalam penjualan, kesalahan pencatatan barang dan kesalahan laporan rugi laba yang dihasilkan. Oleh karena itu dalam sebuah perusahaan harus memiliki sistem yang terotomatisasi sehingga akan menjadi lebih efektif dan mengurangi terjadi kesalahan informasi. Proses pembangun sistem POS berbasis web menggunakan metodelogi pengembangan sistem dengan model waterfall dan bahasa pemograman PHP dengan database MySQL. Hasil penelitian ini mendapatkan sebuah sistem POS yang telah dikembangkan serta dapat melakukan proses transaksi, pengelolaan katagori barang, pengelolaan barang, pengelolaan data supplier, pengelolan pembelian, manajemen pengguna dan pembentukan laporan, dengan demikian dapat membantu dalam proses pengembangan bisnis.Â Kata kunci: Point of sale, Waterfall, PHP, MySQL
Effect of laying hens age and housing system on physicochemical characteristics of eggs
Authors: Nowaczewski Sebastian , Lewko Lidia , Kucharczyk Marta , Stuper-Szablewska Kinga , Rudzińska Magdalena , Cegielska-Radziejewska Renata , Biadała Agata , Szulc Karolina , Tomczyk Łukasz , Kaczmarek Sebastian , Hejdysz Marcin , Szablewski Tomasz 
Published: April 2021

Abstract
In this study, the objective was to evaluate the effect of the age of Hy-line Brown hens – 44 and 60 weeks of age (26 and 42 weeks of laying) and housing system (enriched cages and litter) on the quality of eggs. According to our results, eggs with a better quality of albumen were obtained from younger hens than from older hens. Moreover, older hens produced eggs with inferior quality related to shell parameters, such as greater elastic deformation, poorer breaking strength, and thinner shells. However, hens kept in a litter housing system laid eggs with superior shell quality characteristics of less flexible and greater breaking strength, even though the thickness, weight, and percentage were similar in both housing systems. In addition, a higher amount and activity of lysozyme were obtained from eggs laid by hens kept in the litter housing system than those obtained from hens kept in cages. The maintenance system and age of birds also had a significant (P≤0.05) effect on the basic chemical composition of eggs, as well as on the proportion of individual elements and fatty acid profile. Taking these results into account, we can conclude that the more valuable characteristics from the morphological and nutritional point of view were observed in eggs obtained from younger Hy-line hens kept in the litter housing system.
Coexistence of the BRC Standard for Packaging and the Lean Manufacturing methodology
Authors: Urban Wiesław , Ratter Emil , Wangwacharakul Promporn , Poksinska Bonnie 
Published: April 2021

Abstract
This study aimed to explore the potential impact of the Lean Manufacturing methodology on the implementation and functioning of the BRC Standard for Packaging. The study highlighted many issues where the Lean Manufacturing concept supports and opposes the BRC Standard for Packaging. A framework for the coexistence of both approaches was determined. The study was of a conceptual nature; it adopted an analytical approach. The approach was based on in-depth consideration of each requirement in the BRC Standard for Packaging s and an assessment of the coherence with the Lean Manufacturing methodology. As a result, many conclusions, clues and challenges were found. The article indicates several areas, in which Lean Manufacturing supports the BRC Standard for Packaging, attributing a special positive role to Lean Tools & Techniques. Also, it indicates six areas, in which the BRC Standard for Packaging contradicts the Lean Manufacturing approach. A comprehensive analysis of the coexistence of both management systems allows a better understanding of challenges while implementing both of them in an organisation. The presented concept of the coexistence of both systems is valuable for management.
The Impact of Corporate Income Tax on Gross Domestic Product - The Case of the Republic of Serbia
Authors: Todorović Jadranka Đurović , Đorđević Marina , Krstić Marko 
Published: April 2021

Abstract
The importance of certain tax forms for the economy of any country is confirmed by the fact that they can be used to impact on the achievement of fiscal aims as they play a significant role when it comes to their share in a total amount of public revenue of certain countries. Another important characteristic of taxes is that they can affect the trends of gross domestic product (GDP) as one of the most important economic indicators of achieved development of a national economy. It is for this reason that we must point out that the authors will pay special attention to determining the impact that corporate income tax has on trends of gross domestic product in the Republic of Serbia and their interdependency. This will provide an answer to a question whether corporate income taxes have a positive effect on gross domestic product trends and what is its relation with this indicator. On the basis of quantitative research, through the application of regression analysis, the authors will confirm or refute the hypothesis concerning this problem. Finally, we will reach a conclusion which will offer answers to questions related to the impact of this tax type tax on the gross domestic product trends, the extent of the impact and its nature – whether it has a positive or a negative effect on gross domestic product trends in the Republic of Serbia
Solitary Fibrous Tumor of the Pleura: Case Report and Literature Review
Authors: Stoian Marilena , Indrei Lucia , Stănică Roxana , Stoica Victor 
Published: April 2021

Abstract
Solitary fibrous tumours of the pleura (SFTPs) are rare neoplasms, usually described as relatively benign neoplasms and only 10-20% presenting malignant features. Imagistic investigations are useful in the incipient evaluation of SFTPs, and the histopathological and immunohistochemical examinations after surgical resection are mandatory for establishing the diagnosis and for differentiating SFTPs from other aetiologies of pleural masses. The unpredictable evolution (10%-20% of the cases reported in literature display malignant features) and limited data regarding the treatment needs an early detection, a complete surgical resection and long-term imagistic follow-up. We present a case of SFTPs alongside a review of the typical clinical, imagistic and pathologic features consistent with this diagnosis.
The Napkin-Ring Sign – the Story Behind Invasive Coronary Angiography
Authors: Parajkó Zsolt , Kovacs István , Chițu Monica , Benedek Imre 
Published: April 2021

Abstract
Coronary artery disease (CAD) represents one of the leading causes of morbidity and mortality across Europe. Most of the patients do not experience any warning sign before the coronary event develops, therefore screening this group of patients is essential to prevent major cardiac events. Coronary computed tomography angiography (CCTA) offers a noninvasive approach of the coronary arteries, providing information not only on the presence and severity of the coronary stenosis, but is also able to characterize the structure of the coronary wall. CCTA allows complex evaluation of the extension of CAD, and by assessing the structure of the atherosclerotic plaque, it can identify its degree of vulnerability. The napkin-ring sign (NRS) represents a ring-like attenuation of the non-calcified portion of the coronary lesion and has a high specificity (96–100%) for the identification of thin cap fibroatheroma (TCFA) or culprit lesion in acute coronary syndromes (ACS). It is also an independent predictor for ACS events and the strongest predictor for future ACS. Modern CCTA can provide submillimeter isotropic spatial resolution. Thus, CT attenuation-based tissue interpretation enables the assessment of total coronary plaque burden and individual plaque components, with a similar accuracy as intravascular ultrasoud-based investigations. This review aims to present the important role of CCTA as a potent screening tool for patients with CAD, and the current evidences in the detection and quantification of vulnerable plaques.
Management of Culprit and Non-Culprit Lesions in Acute Coronary Syndrome
Authors: Gerculy Renáta , Mitra Noémi , Szabó Evelin , Opincariu Diana , Chițu Monica , Benedek Imre 
Published: April 2021

Abstract
Multivessel coronary artery disease, defined by the presence of a significant stenosis (≥50% diameter) in two or more epicardial coronary vessels, usually occurs in more than 50% of patients with ST-segment elevation myocardial infarction. The latest guidelines indicate revascularization of the non-culprit artery with a recommendation of class IIB. However, the management of non-culprit lesions in patients with acute coronary syndrome is still a matter of debate. This article presents the most recent concepts related to the management of culprit and non-culprit coronary lesions, based on advanced imaging approaches, in order to identify high-risk patients and prevent further acute coronary syndromes.