bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identified micro-organisms in hospitalized community-acquired pneumonia patients living near goat and poultry farms
Authors: Roof Inge , van Gageldonk-Lafeber Arianne B. , Zomer Tizza P. , Vermeeren Yolande M. , Wever Peter C. , van der Hoek Wim 
Published: November 2021

Abstract
Background
In the Netherlands, an increased risk of community-acquired pneumonia (CAP) has been reported for adults living near goat and poultry farms. Previous results of respiratory microbiome studies in hospitalized CAP patients near poultry farms suggested a higher relative abundance of Streptococcus pneumoniae. This retrospective study, using routine laboratory data from hospitalized CAP patients, aims to explore possible aetiologic micro-organisms of CAP in relation to livestock exposure.

Methods
Patient characteristics and PCR and urinary antigen test results were retrieved retrospectively from electronic medical records of CAP patients admitted to the Jeroen Bosch Hospital or Gelre Hospital in the Netherlands during 2016–2017. Distances between the patients’ home address and the nearest poultry and goat farm were calculated. Differences in laboratory test results between CAP patients with and without goat or poultry farms within 2 km of their home address were analyzed using Fisher’s exact test.

Results
In total, 2230 CAP episodes with diagnostic results were included. In only 25% of the CAP episodes, a micro-organism was detected. A positive urinary antigen test for S. pneumoniae was found more often in patients living within two kilometers of goat (15.2% vs. 11.3%) and poultry farms (14.4% vs. 11.3%), however these differences were not statistically significant (p = 0.1047 and p = 0.1376).

Conclusion
Our retrospective analysis did not show statistically significant differences in the identified micro-organisms in hospitalized CAP patients related to livestock farming. The study was hampered by limited statistical power and limited laboratory results. Therefore, the potential increased CAP risk around goat and poultry farms will be further explored in a prospective study among CAP patients in primary care.
What is a traditional food? Conceptual evolution from four dimensions
Authors: Rocillo-Aquino Zeltzin , Cervantes-Escoto Fernando , Leos-Rodríguez Juan Antonio , Cruz-Delgado Daniela , Espinoza-Ortega Angélica 
Published: November 2021

AbstractThe purpose was to specify the concept of traditional food and the dimensions that make it up, identifying: definitions, authors and research projects; as well as to determine what is known and possible topics for future research. A literature review of traditional foods was conducted that examined the conceptual development of the term. Social network analysis (SNA) was also used to identify the most relevant definitions and working groups on the topic. Twenty-three definitions were identified in the period 1995–2019. It reveals the difficulty of establishing one that encompasses such a dynamic concept. Although there is variability in the specific characteristics of these foods, four dimensions have been established: time, place, know-how, and cultural meaning. It was found that their main characteristic is the transmission of knowledge and raw materials between generations. The conceptualization of the term has been developed mainly in Europe, based on the perspective of consumers. New trends in research include the contrast and complementarity of innovation in traditional foods and the difference between these products and those named with similar attributes such as typical, regional, ethnic, local, among others. Social network analysis (SNA) was used to study the definitions of a concept, something that had not been done with this approach. Suggestions are made for possible research on the subject, such as the conceptual delimitation of related terms and the compatibility between innovation and tradition.
Wild European dewberry, Rubus caesius L. (fam. Rosaceae), in Sweden: from traditional regional consumption to exotic dessert at the Nobel Prize banquet
Authors: Svanberg Ingvar , Ståhlberg Sabira 
Published: November 2021

AbstractEuropean dewberry, Rubus caesius L. (fam. Rosaceae), played an insignificant role as local food in Sweden before the twentieth century. It is known as salmbär ‘Solomon berries’ in the severely endangered regional language Gutnish, spoken in the Baltic Sea islands Gotland and Fårö. From a largely ignored food product with limited regional use, European dewberry has made a quick culinary journey to the top. Today dewberry jam is popular throughout Sweden, and it is usually served during festive occasions with a local Gotland specialty, oven-baked saffron pancake. This dish symbolizes the food culture of the island, and the demand for dewberries has increased together with the development of local tourism, the search for exciting heritage food, and the regional identity building efforts. Berries are harvested by foreign seasonal workers for commercial purposes, and dewberry jam is now also available in specialized shops in mainland Sweden. Inspired by the New Nordic Cuisine movement in the 2000s, several chefs, especially from fine dining restaurants, have created innovative dishes with dewberry jam; it was even served at the Nobel Prize banquet in December 2014. This article discusses the change of status and ascent of a locally used berry to a fashionable dessert in Sweden.
Sensitivity to tumor development by TALEN-mediated Trp53 mutant genes in the susceptible FVB/N mice and the resistance C57BL/6 mice
Authors: Yun Woo Bin , Kim Ji Eun , Lee Mi Lim , Choi Jun Young , Park Jin Ju , Song Bo Ram , Kang Byeong Cheol , Nam Ki Taek , Lee Han-Woong , Hwang Dae Youn 
Published: November 2021

Abstract
Background
This study was undertaken to compare the sensitivities of mice strains during tumor induction by transcription activator-like effector nucleases (TALEN)-mediated Trp53 mutant gene. Alterations of their tumorigenic phenotypes including survival rate, tumor formation and tumor spectrum, were assessed in FVB/N-Trp53em2Hwl/Korl and C57BL/6-Trp53em1Hwl/Korl knockout (KO) mice over 16 weeks.

Results
Most of the physiological phenotypes factors were observed to be higher in FVB/N-Trp53em2Hwl/Korl KO mice than C57BL/6-Trp53em1Hwl/Korl KO mice, although there were significant differences in the body weight, immune organ weight, number of red blood cells, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet count (PLT), total bilirubin (Bil-T) and glucose (Glu) levels in the KO mice relative to the wild type (WT) mice. Furthermore, numerous solid tumors were also observed in various regions of the surface skin of FVB/N-Trp53em2Hwl/Korl KO mice, but were not detected in C57BL/6-Trp53em1Hwl/Korl KO mice. The most frequently observed tumor in both the Trp53 KO mice was malignant lymphoma, while soft tissue teratomas and hemangiosarcomas were only detected in the FVB/N-Trp53em2Hwl/Korl KO mice.

Conclusions
Our results indicate that the spectrum and incidence of tumors induced by the TALEN-mediated Trp53 mutant gene is greater in FVB/N-Trp53em2Hwl/Korl KO mice than C57BL/6-Trp53em1Hwl/Korl KO mice over 16 weeks.
Impact of the nutritional status of children with congenital heart diseases on the early post-operative outcome
Authors: Ismail Sameh R. , Mehmood Akhter , Rabiah Noura , Abu-sulaiman Riyadh M. , Kabbani Mohamed S. 
Published: November 2021

Abstract
Background
Children with congenital heart disease (CHD) frequently become malnourished due to many factors including hypermetabolic state, inadequate caloric intake, malabsorption, and fluid restriction as part of the hemodynamic intervention. The abnormal nutritional status may affect early outcome after pediatric cardiac surgery; we aim to prove the importance of nutritional assessment and patient nutritional preparation before performing pediatric cardiac surgery.

Results
We conducted a prospective observational cohort study from March 2013 till January 2015. All children from birth until 14 years of age admitted to the pediatric cardiac intensive care unit (PCICU) after cardiac surgery. Nutritional status was assessed preoperatively and prognostic nutritional index (PNI) was calculated. All post-operative outcome parameters, PCICU and hospital length of stay (LOS), ventilation time, the rate of infection, and ICU mortality were recorded. Two hundred fifty-nine children were evaluated. At admission, 179 patients (69%) had intake less than 50% of the recommended daily allowance (RDA) of calories intake. There was a statistically significant relationship between pre-admission RDA and the infection rate (P value 0.018). Severely malnourished patients had significantly longer ICU length of stay (LOS) (P value = 0.049). Similarly, weight and height percentiles have a significant effect on ICU LOS (P value 0.009 and 0.045) respectively. There was a significant relation between PNI ≥ 55 and the ICU LOS (P < 0.05), and ventilation time (P = 0.036). Delay in feeding postoperatively was associated with a higher risk of infection (P = 0.005), and higher mortality (P = 0.03).

Conclusions
Children with CHD were significantly malnourished preoperatively and had further weight loss postoperatively. Preoperative nutritional status and delayed postoperative enteral feeding were associated with a higher infection rate and mortality.
FDG PET/CT in follow UP patients with colorectal carcinoma after adjuvant chemotherapy
Authors: Elia Remon Zaher , Elbastawessy Rafik Abdelazem , Abdelmgeguid Hanaa Abdelkader , Bassiouny Ahmed Mohamed 
Published: November 2021

Abstract
Background
18F-2-fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) is a method of imaging that assesses and measures metabolic avidity in cancer cells, acting as a proxy for underlying cellular activity and vitality and so providing anatomic and metabolic information. 18F-FDG PET-CT is beneficial for detecting local recurrence, distant metastases, and monitoring tumor viability after chemotherapy and radiotherapy in patients with colorectal cancer. Strict adherence to set protocols, technological processes, and good patient preparation are essential to produce the greatest results. The goal of the trial was to see how useful PET/CT was in following up on patients who had resected colorectal cancer and had completed adjuvant chemotherapy rounds.

Results
In this study, PET/CT early detected hepatic deposits, pulmonary masses, bone deposits, and sizable LNs. PET/CT provided useful information and had a considerable impact on disease management, enabling the detection of recurrent disease as early as possible with high accuracy in assessment of therapeutic response. It detected viable residual tumor cells in operative bed scar, small metabolically active LNs, hepatic focal lesions, peritoneal deposits, pulmonary secondaries, and bone deposits avoiding unnecessary surgeries.

Conclusion
Because of its high accuracy in detection and capacity to identify recurrent illness, FDG-PET-CT imaging is effective in evaluating post-therapeutic colorectal cancer patients with suspected tumor recurrence or distant metastases.
Assessment of Breast Cancer Management in Sub-Saharan Africa
Authors: Vanderpuye Verna , Dadzie Mary-Ann , Huo Dezheng , Olopade Olufumilayo I. 
Published: November 2021

PURPOSE To document progress and bottlenecks in breast cancer management in sub-Saharan Africa, subsequent to a 2013 pilot survey conducted through the African Organization for Research and Treatment in Cancer (AORTIC) network. METHODS An anonymous survey of breast cancer management was conducted in 2018 among AORTIC members. Results concerning respondent specialty, access to tumor boards, treatment accessibility, diagnostic services, and factors influencing treatment outcomes were compared with the 2013 findings. RESULTS Thirty-seven respondents from 30 facilities in 21 sub-Saharan Africa countries responded. The majority (92%) were clinical oncologists. Radiotherapy facilities were available in 70% of facilities. Seventy-eight percent of these had linear accelerators, and 42% had cobalt60 machines. Eighty percent of facilities had multidisciplinary tumor boards. Immunohistochemistry was routinely performed in 74% of facilities, computed tomography scan in 90%, bone scan in 16%, and positron emission tomography scans in 5%. Anthracyclines, taxanes, tamoxifen, letrozole, anastrozole, and zoledronic acid were available in the majority; trastuzumab, fertility, and genetic counseling were available in 66%, 58%, and 16%, respectively. There were a 50% increase in oncologist respondents over 2013 and a > 50% increase in radiotherapy facilities, particularly linear accelerators. Availability of trastuzumab, aromatase inhibitors, and taxanes increased. Immunohistochemistry capacity remained the same, whereas facilities harvesting at least 10 axillary lymph nodes increased. Bone scan facilities decreased. Responses suggested improved diagnostic services, systemic therapies, and radiotherapy. Sociocultural and economic barriers, system delays, and advanced stage at presentation remain. CONCLUSION Clinicians in sub-Saharan Africa have basic tools to improve breast cancer outcomes, recording positive strides in domains such as radiotherapy and systemic therapy. Socioeconomic and cultural barriers and system delays persist. Workforce expansion must be prioritized to improve quality of care to improve outcomes.
Poziotinib in Non–Small-Cell Lung Cancer Harboring HER2 Exon 20 Insertion Mutations After Prior Therapies: ZENITH20-2 Trial
Authors: Le Xiuning , Cornelissen Robin , Garassino Marina , Clarke Jeffrey M. , Tchekmedyian Nishan , Goldman Jonathan W. , Leu Szu-Yun , Bhat Gajanan , Lebel Francois , Heymach John V. , Socinski Mark A. 
Published: November 2021

PURPOSE Insertion mutations in Erb-b2 receptor tyrosine kinase 2 gene ( ERBB2 or HER2) exon 20 occur in 2%-5% of non–small-cell lung cancers (NSCLCs) and function as an oncogenic driver. Poziotinib, a tyrosine kinase inhibitor, was evaluated in previously treated patients with NSCLC with HER2 exon 20 insertions. METHODS ZENITH20, a multicenter, multicohort, open-label phase II study, evaluated poziotinib in patients with advanced or metastatic NSCLC. In cohort 2, patients received poziotinib (16 mg) once daily. The primary end point was objective response rate evaluated by independent review committee (RECIST v1.1); secondary outcome measures were disease control rate, duration of response, progression-free survival, and safety and tolerability. Quality of life was assessed. RESULTS Between October 2017 and March 2021, 90 patients with a median of two prior lines of therapy (range, 1-6) were treated. With a median follow-up of 9.0 months, objective response rate was 27.8% (95% CI, 18.9 to 38.2); 25 of 90 patients achieved a partial response. Disease control rate was 70.0% (95% CI, 59.4 to 79.2). Most patients (74%) had tumor reduction (median reduction 22%). Median progression-free survival was 5.5 months (95% CI, 3.9 to 5.8); median duration of response was 5.1 months (95% CI, 4.2 to 5.5). Clinical benefit was seen regardless of lines and types of prior therapy, presence of central nervous system metastasis, and types of HER2 mutations. Grade 3 or higher treatment-related adverse events included rash (48.9%), diarrhea (25.6%), and stomatitis (24.4%). Most patients had poziotinib dose reductions (76.7%), with median relative dose intensity of 71.5%. Permanent treatment discontinuation because of treatment-related adverse events occurred in 13.3% of patients. CONCLUSION Poziotinib demonstrates antitumor activity in previously treated patients with HER2 exon 20 insertion NSCLC.
The Divided Liang Dynasty Literary World Seen through the Liu-Dao Dispute
Authors: Xiaomeng Wang , Chen Jing 
Published: November 2021

Abstract
The tension between the literary styles of Liu Xiaochuo 劉孝綽 (481–539) and Dao Qia 到洽 (490–527) can be understood as a debate between poetic genius and a more scholarly focus, signaling a confrontation between the capital's literary camps in the Putong reign 普通 (520–527) of the Liang Dynasty 梁 (502–557). The major difference between the literary camps lies in the consideration given to natural poetic talent versus erudition in writings. When Xiao Gang 蕭綱 (503–551), Liu Xiaochuo's supporter, became crown prince in 531, his own conflict with the scholarly group including Dao Gai 到溉 (477–548) and Zhu Yi 朱异 (483–540) probably prompted his “Letter to the Prince of Xiangdong” 與湘東王書 (Yu Xiangdong Wang shu). In this letter Xiao Gang displays his literary view deemphasizing scholarly learning and erudition in poetry. By comparison Xiao Yan 蕭衍 (464–549) and Xiao Yi 蕭繹 (508–555) valued scholarly learning still more and regarded literature as a relatively insignificant talent or minor accomplishment. Xiao Gang represents a departure—by placing literary talent above scholarship, he catered to the fashion among the Liang Dynasty's nobility for reciting poetry and writing fu 賦 (rhapsody) while “rarely taking classical studies as their profession” 罕以經朮為業 and thus elevated the social status of belles lettres.
The Making and Unmaking of Nationalist Literature from the National Margin
Authors: Xie Miya Qiong 
Published: November 2021

Abstract
This article reconsiders the established modern Chinese writer Duanmu Hongliang and his first and most influential work, The Korchin Banner Plains (completed in 1933 and published in 1939), from a borderland perspective. The novel is set in western Manchuria, a multiethnic area of northeastern China that borders Inner Mongolia and was occupied by Japan in the early 1930s. The novel has been read by many as a realistic portrait of the natural and social landscape of the grassland and as an autobiographical account of the author's family history. This article disagrees, and treats the novel as a performative form of “territory-making” that purposefully recreates a Han-centered modern nation from its geographical margin by carefully reorganizing a web of intricate and competing multiethnic and multinational relations in the grassland. In particular, as a self-identified Manchu, Duanmu makes unconventional choices of both themes and literary styles to imply a calculated embrace of a modern nation by an ethnic other. Through a close examination of the spatial-textual negotiations in the novel, the article delineates how a classic work of nationalist literature was produced from the borderland and how this work exposes the precariousness and contradictions inherent in the grand narrative of modern nationhood.
Shen Congwen's Idealized Ethnic
Authors: Zhang Yanshuo 
Published: November 2021

Abstract
This article investigates the underexamined ethnic motifs of the modern literary master Shen Congwen's 沈從文 fictional creations. In the field of Chinese literary scholarship, Shen is widely recognized as a leading figure of the May Fourth “native soil” literary tradition and is usually labeled as a “regionalist” writer. Yet as an ethnically hybrid author, Shen's ethnographically inspired, mythologizing accounts of indigenous non-Han tribes place him in a long tradition of searching for moral truths in borderland societies in Chinese literary and cultural history. The article argues that ethnicity is an important motif that runs throughout the early Shen Congwen's literary oeuvre, particularly in the Miao-themed stories that he crafted in the 1920s and 1930s. Shen idealizes non-Han peoples, particularly the Miao in southern China's borderland, as the ultimate source of moral courage and aesthetic perfection in his vision of a wholesome China. Through his ethnically themed novellas and short stories, Shen is both heir to and questions the Confucian tradition of locating a civilizational “other” in the non-Sinitic/non-Han border regions. The article further reveals how Shen embodies contradictory motifs with regard to ethnicity in China: on the one hand, he romanticizes the Miao as moral agents living freely in a timeless society, governed only by divine powers and unruly passions. On the other hand, Shen laments the historical discrimination experienced by the Miao and assumes a sober voice as he calls for ethnic equality. Simultaneously lyrical and political, Shen's ethnically themed works are significant for forming new scholarly understandings of both May Fourth literature and the broader discourse of ethnicity, which underpins the very notion of Chineseness in modern China.
Unsavory Characters
Authors: Peacock Christopher 
Published: November 2021

Abstract
From early works such as “Ralo” (1997) to the more recent “Black Fox Valley” (2012), the acclaimed Tibetan author Tsering Döndrup has demonstrated a consistent interest in the impact of the Chinese language on Tibetan life. This article examines the techniques and implications of Tsering Döndrup's use of Chinese in his Tibetan language texts, focusing on his recent novella “Baba Baoma” (2019), the first-person account of a rural Tibetan boy who attends a Chinese school and ends up stuck between two languages. In a major departure from Tsering Döndrup's previous work on the language problem, this text directly incorporates untranslated Chinese characters, blending them with Tibetan transliterations and Hanyu Pinyin (i.e., the Latin alphabet) to create a deliberately disorienting linguistic collage. This article argues that this latest work pushes Tsering Döndrup's previous experiments to their logical conclusion: a condition of forced bilingualism, in which the author demands of his readers fluency in Chinese in order to access his Tibetan language fiction. This critique of the Sino-Tibetan linguistic crisis puts the author's work into conversation with global postcolonial literatures and the politics of resistance to language hegemony. By demonstrating the Tibetan language's capacity for literary creation, the story effectively resists the hegemony it depicts, even while it suggests that the Tibetan literary text itself is in the process of being fundamentally redefined by its unequal encounter with the Chinese language.
Frequency of parasitic infections in Arachishypogaea L (groundnuts), Citrulluslanatus seeds (watermelon seeds), and Ziziphusspina-christi (nabag) sold by street vendors in Khartoum State, Sudan: a cross-sectional study
Authors: Suleiman Mohammed Arwa , Abd Alla Ahmed , Galander Ahmed , Elfaki Tayseer , Ibrahim Hashim Ahmed , N. Altayb Hisham 
Published: November 2021

Background: Plant products, including seeds are an important source of vitamins, minerals, proteins, and energy. This study aimed to assess parasitic contaminations in roasted groundnuts, nabag, and tasali (watermelon seeds) sold by street vendors in Khartoum State, Sudan. Methods: The frequency of parasitic contaminations among all crop products was detected by washing the plants with saline, and then conducting an examination using a formal ether concentration technique (FECT), followed by a saturated sugar floatation technique. Results: The detected parasites belonged to two species: Entamoeba histolytica (33.3%) and Giardia lamblia (15.6%). No helminthic parasites were detected. Mixed contamination of the mentioned parasites was also observed (11.1%). The most contaminated crop was nabag, followed by groundnut, and finally tasali. Conclusion: No relation was established between the positivity of samples for parasites and crop type, Khartoum State city, or seller sex. FECT was more sensitive than the saturated sugar floatation technique as a detection method.