bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating The Contribution of Wetlands To Food Security And Livelihoods Improvement In The Savelugu Municipality, Ghana
Authors: Atiim Justice Awen-Natey , Alhassan Elliot Haruna , Abobi Seth Mensah 
Published: August 2021

Abstract
The study was conducted on three wetlands and four fringe communities in the Savelugu Municipality in Ghana's Northern Region. The study evaluated the importance of wetlands to food security and livelihoods in the Savelugu Municipality using primary and secondary data sources. The contingent valuation method was used to determine respondents' value of wetlands, whereas Kendall's Coefficient was used to identify the factors influencing the reliance or utilisation of wetlands. The study results showed that wetlands were critical resources in study communities and contributed to people livelihoods and food security and determining the kinds of livelihoods that existed in these communities. Furthermore, the study established that despite the potential contributions of these ecosystems to the people's overall development, the wetlands are yet to be accorded the needed recognition as valuable resources by policymakers at the community and district levels. The disregard of wetland ecosystems by authorities, and as a consequence, the lack of attention/clear-cut regulations on their use, lead to overexploitation and degradation. It was observed in especially the Bunglung and Nabogu wetlands that siltation was having a toll on their capacity and would take only higher authorities to dredge considering the cost involved. Key among the factors influencing wetland dependence and utilisation were climate change, soil fertility of wetlands and household income levels. Inhabitants' activities such as obsolete fishing tools and farming practices, channelisation and indiscriminate waste disposal were identified to be detrimental to the wetlands' sustainability.
CIGB-300 Synthetic Peptide, an Antagonist of CK2 Kinase Activity, as a Treatment for Covid-19. A Computational Biology Approach
Authors: Miranda Jamilet , Bringas Ricardo , Fernandez-de-Cossio Jorge , Perera-Negrin Yasser 
Published: August 2021

Abstract
Background: Similarities in the hijacking mechanisms used by SARS-CoV-2 and several type of cancer, suggest the repurposing of cancer drugs to treat Covid-19. CK2 kinase antagonists have been proposed for the treatment of cancer. A recent study in cells infected with SARS-CoV-2 virus found a significant CK2 kinase activity, and the use of a CK2 inhibitor showed antiviral responses. CIGB-300, originally designed as an anticancer peptide, is an antagonist of CK2 kinase activity that binds to CK2 phospho-acceptor sites. Recent preliminary results show an antiviral activity of CIGB-300 versus a surrogate model of coronavirus. Here we present a computational biology study that provides evidences at the molecular level of how CIGB-300 might interfere with SARS-CoV-2 life cycle inside infected human cells. Methods: Sequence analysis and phosphorylation studies data were combined to predict infection-induced molecular mechanism that can be interfered by CIGB-300. Next we integrated multi-omics data on SARS-CoV-2 infection and data on the antagonistic effect on CK2 kinase activity of CIGB-300 to predict the potential benefits of its treatment in COVID-19 patients. A combination of network and functional enrichment analysis was used.Results: First, from SARS-CoV studies, we infer the potential incidence of CIGB-300 in SARS-CoV-2 interference on immune response. Next, from the analysis of multiple Omics data, we propose the action of CIGB-300 since early stage of viral infections perturbing the virus hijacking of RNA splicing machinery. It was also predicted the interference of CIGB-300 in virus-host interactions responsible for the high infectivity and the particular immune response to SARS-CoV-2 infection. Further, we provide evidences of CIGB-300 attenuation of phenotypes related to muscle, bleeding, coagulation and respiratory disorders.Conclusions: We have evidenced the potential benefits of using CIGB-300 to treat COVID-19 patients and strongly suggest its use since early stages of viral infection.
Surgical Treatment of Periprosthetic Acetabular Fracture: A 5 Cases Report and Literature Review.
Authors: Cong Yuxuan , Han Shuang , Deng Hongli , Zhang Binfei , Ke Chao , Fei Chen , Zhuang Yan , Huang Hai 
Published: August 2021

Abstract
Background: With the increasing number of patients undergoing total hip arthroplasty(THA) in recent years, the incidence of periprosthetic acetabular fractures is increasing, which is one of the most serious complications after THA. Periprosthetic acetabular fracture caused by trauma is rare, and it requires orthopedic surgeons to deal with acetabular fracture and component loosening at the same time. This article summarizes 5 cases of periprosthetic acetabular fracture that have undergone surgical treatment, we propose the reverse press-fit technology to increase the stability of fixation for this clinical rare diseases. And the literature for treatment recommendations is reviewed.Case presentation: A total of 5 patients (3 female) were included, the average patient age at the time of injury was 66.2 years (range 54–78 years). All patients received surgical treatment, 4 cases were treated with open reduction and internal fixation(ORIF), 1 case was treated with revision surgery. There were no postoperative complications. All patients could walk independently on the latest follow-up.Conclusions: The surgical treatment option of periprosthetic acetabular fracture is ORIF or revision surgery, and the purpose is to make the component stabilized. The reverse press-fit technology could improve the fixation strength between the component and bone, and it can be performed in appropriate situation.
Awareness and Community Response To Stroke Signs and Symptoms Following the National ‘Act Fast’ Campaign in An Ethnically Diverse Population
Authors: Bhutta Zain A. , Pathan Sameer A. , Puolakka Tuukka , Akhtar Naveed , Thomas Stephen H. , Harris Tim , Shuaib Ashfaq , Cameron Peter A. , Castren Maaret 
Published: August 2021

Abstract
Background

Evaluation of public education stroke campaigns and behavioral studies to assess emergency response at stroke onset are scarce. We aimed to assess patient’s and bystanders’ foreknowledge of stroke signs and symptoms and their response at stroke onset. We also enquired if ‘Act FAST’ stroke campaign in Qatar contributed to their foreknowledge.
Methods

In Qatar, the first national stroke awareness campaign, ‘Act FAST’, was launched in May 2015. The study population included a convenience sample of stroke patients admitted to the stroke service in Qatar’s largest tertiary care hospital from November 2015-February 2016. We interviewed patients with acute onset stroke admitted to the stroke unit using a validated questionnaire. If the patient had disabling stroke, we interviewed relatives/bystanders present at stroke onset. The primary outcome was the correct response of calling Emergency Medical Services (EMS), recognizing the possibility of stroke.
Results

The questionnaire was administered to 165 participants, 142 (86.1%) stroke patients, and 23 (13.9%) bystanders. The mean age of the study population was 52.6 (SD = 11.7), and sex (male-female) ratio was 7:1. Ethnic categories were South-Asian (n = 101, 62.2%), Middle-Eastern (n = 14, 8.5%), Far-Eastern (n = 26, 15.8%), African (n = 16, 9.7%) and Others (n = 8, 4.9%). From the study group, 33 (20.1%) participants had foreknowledge of stroke signs and symptoms, and of these, 27 (16.5%) knew about the Act FAST campaign in Qatar. The behavioral responses of the participants (total n = 165) on stroke onset included; immediately activated EMS (n = 55, 33.3%), called friends/relatives (n = 69, 41.8%), drove to hospital (n = 33, 20%), decided to rest and waited for improvement in condition (n = 21, 12.7%), and 12 (7.3%) responded as none of the above. Of the participants who admitted having watched the Act FAST campaign, 92.6% (25/27) reported that the campaign affected their response to stroke onset. There was no association of ethnicity, marital status or FAST campaign awareness with behavioral response of EMS activation on stroke onset.
Conclusions

The foreknowledge of stroke signs and symptoms and the Act FAST campaign was low in the community. However, seeking help by activating EMS at stroke onset was generally high in the study population irrespective of the awareness to the campaign.
Full quantum state tomography of high-dimensional on-chip biphoton frequency combs with randomized measurements
Authors: Lu Hsuan-Hao , Myilswamy Karthik , Bennink Ryan , Seshadri Suparna , Alshaykh Mohammed , Liu Junqiu , Kippenberg Tobias , Leaird Daniel , Weiner Andrew , Lukens Joseph 
Published: August 2021

Abstract
Owing in large part to the advent of integrated biphoton frequency combs (BFCs), recent years have witnessed increased attention to quantum information processing in the frequency domain for its inherent high dimensionality and entanglement compatible with fiber-optic networks. Quantum state tomography (QST) of such states, however, has required complex and precise engineering of active frequency mixing operations, which are difficult to scale. To address these limitations, we propose a novel solution that employs a pulse shaper and electro-optic phase modulator (EOM) to perform random operations instead of mixing in a prescribed manner. Incorporating state-of-the-art Bayesian statistical method, we successfully verify the entanglement and reconstruct the full density matrix of BFCs generated from an on-chip Si3N4 microring resonator (MRR) in up to an 8×8-dimensional two-qudit Hilbert space, the highest dimension to date for frequency bins. Overall, our method furnishes an experimentally powerful approach for frequency-bin tomography with readily implementable operations.
Genetic Relationship And Species Identification of Dioscorea Polystachya Turcz. In Yams Determined By ISSR, ISAP, SRAP And SCAR Markers
Authors: Yue Wang , Zixia Gu , Min Chen , Yanmei Zhang , Xiaoqin Sun , Yifeng Zhou , Peng Bin 
Published: August 2021

Abstract
Dioscorea polystachya Turcz. is the authentic herb Yam in Chinese traditional medicine. In the medicine market, some relative species are misused as “Yams”, such as D. alata L., D. exalata C.T. Ting & M.C. Chang, D. persimili Prain et Burkill, D. fordii Prain et Burkill and D. japonica Thunb. In order to estimate the genetic relationships among those species and develop a rapid and accurate method for D. polystachya identification, Inter Simple Sequence Repeat (ISSR), Intron Sequence Amplified Polymorphism (ISAP), Sequence-Related Ampliﬁed Polymorphism (SRAP) and Sequence Characterized Amplified Region (SCAR) were conducted in this study. Combining ISSR, ISAP and SRAP markers, a high degree of variation among the Dioscorea species was detected. Moreover, a relatively high gene flow (Nm = 0.3293) in those species was observed. The main reason for this phenomenon might be there were genepools exchanging in the wild materials. The phylogenetic tree and genetic similarity results showed D. japonica had the closest genetic relationship with D. polystachya. Considering the lowest inter-species variation observed in D. polystachya and the highest genetic divergence within D. japonica, we suggested the taxonomy of one species complex D. polystachya-D. japonica for breeding and conservation purpose. The phylogeny data in this study indicated D. alata and D. persimilis should be independent species respectively instead of cultigens. Furthermore, a SCAR marker was developed and could be used to discriminate the authentic herb D. polystachya from other confused Dioscorea species. Overall, the results are useful as guidelines for breeding programs and conservation actions.
Prevalence of Stroke Risk Factors in an Urban Community at Parakou (Northern Benin) in 2016
Authors: Houehanou Yèssito Corine Nadège , Agbetou Mendinatou , Kossi Oyéné , Agonnoudé Maurice , Hountada Hospice , Adoukonou Thierry 
Published: August 2021

Abstract
Background: Sub-Saharan Africa faces a high burden of stroke due to growing of their risk factors. We aimed to estimate the prevalence of stroke risk factors and to identify associated factors in the district of Titirou in Parakou (northern Benin), in 2016.Methods: It was a cross-sectional study. It included adults living in Titirou and having given their consent. A door-to-door survey was performed from 15 march to 15 July 2016 in each neighbourhood or village until the expected number reached. We recorded the socio-demographic data, medical histories, anthropometric and blood pressure measures using WHO steps approach. Prevalences of stroke risk factors were calculated and a logistic regression was done to identify factors associated with metabolic risk factors.Results: A total of 4671 participants was included with a mean age of 27.7±12.9 years and a sex ratio of 0.97. Prevalences of behavioural risk factors were estimated at: 17.2% of alcohol consumption, 21.5% of low fruits and vegetables consumption, 51.1% of low physical activity practice, and 3.5% of smoking. Metabolic risk factors prevalence’s amounted to: 8.7% of obesity, 7.1% of high blood pressure, 1.7% of self-reported diabetes and 2.2% of dyslipidaemia. Age (p<0.001), sex (p<0.001), marital status (p<0.001) and professional occupation (p=0.010) were associated with obesity. Age was also associated with high blood pressure (p<0.001) and diabetes (p<0.001). Dyslipidaemia varied according to smoking (p=0.033) and low physical activity practice (p=0.003). Conclusion: The study showed high prevalences of low physical activity practice and obesity. Targeted local interventions focused on these factors should be conducted for primary prevention of stroke in this community, or even beyond in Benin.
Online Learning During Corona Virus 2019: Empirical Analysis
Authors: Bhatti Muhammad Tariq , Teevno Roshan , Bukhari Syed Gulzar Ali Shah 
Published: August 2021

Abstract
Corona Virus Disease (COVID-19) was declared a worldwide pandemic by the World Health Organization (WHO) on mid of March 2020. Globally, most governments - including Pakistan - approved extraordinary social control measures to stem the tide of this pandemic disease. These actions required social segregation and a temporary suspension of education. As with all other institutions of higher education, public and private universities will also be required to offer distance learning to students by the end of the academic year 2020–2021. Universities suspended physical classes and implemented online teaching for university students. And, this spontaneous, quick, and uncertain nature of the teaching created difficulties for students. Data on accepted procedures for directing such sudden transitions to university education were scarce, and there was no consensus on the best way to proceed. Students at public and private universities have been impacted by a shift to distance education. Studying students' academic difficulties and the unexpected benefits of distance education, and then using that information to develop strategies that could be used in emergency situations in university education, was the goal of the study.
Association between deposit of abdominal adipose tissues and metabolic abnormality in a Chinese population
Authors: Zhang Xuhui , Chen Qiannan , Sun Xiaohui , Wu Qiong , Cheng Zongxue , Lv Qingguo , Zhou Jiaqiang , Zhu Yimin 
Published: August 2021

Abstract
BackgroundPrevious studies indicated that deposit of abdominal adipose tissue associated with the abnormalities of cardiometabolic components. However, the results were inconsistent on the effects of subcutaneous adipose tissue (SAT) and difference between men and women. The aim of this study was to examine the associations of VAT, SAT with metabolic status and the different effects between male and female. Methods1388 eligible subjects were recruited from the baseline investigation of metabolic syndrome investigation in China. Areas of abdominal VAT and SAT were determined by nuclear magnetic resonance imaging (MRI). Total triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) were measured by biochemical auto-analyzer. Metabolic abnormality (MA) was defined more than one of abnormally metabolic components, which were based on the definition of metabolic syndrome (IDF 2005). Multiple logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (95%CI). The predictive values were assessed with area under the curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI), respectively. ResultsSubjects with MA had higher levels of VAT in both of men and women, and higher levels of SAT in men than those with metabolic normality (MN) (P< 0.05). Different associations of SAT in women depended of levels of BMI. Higher levels of VAT were significantly correlated with higher risks for MA (p for trend <0.05). Comparing with the subjects of the first quartile (Q1) of VAT, OR in fourth quartile (Q4) was 6.537 (95% CI= 3.394 -12.591) in men and 3.364 (95% CI=1.898-5.962) in women. However, no significance was found in SAT. In men, VAT improved the predictive value of MA with the AUC of 0.727 (95% CI= 0.687-0.767), and NRI of 0.139 (95%CI=0.070-0.208) and 0.106 (95%CI=0.038-0.173), IDI of 0.074 (95%CI = 0.053-0.095) and 0.046 (95%CI=0.026-0.066) comparing with BMI and WC, respectively. Similar results were found in women.Conclusions VAT and SAT linked increased risks for metabolic abnormality in men no matter in the BMI＜24kg/m2 or in BMI≥24kg/m2, but in women, SAT only increased the risk of MA in BMI≥24kg/m2.Deposit of abdominal adipose tissue associated with the metabolic abnormalities. VAT improved the predictive ability of MA.
The Prognostic Value of a Glycolysis -Related lncRNA Signature in Non-Small Cell Lung Cancer
Authors: Dong Yongquan , Xia Wenping , Zhu Hefei , Lu Feijie , Wei Lijuan , Li Qianjun , Zhao Qiong 
Published: August 2021

Abstract
Backgroud: Long non-coding RNA(lncRNA) is a new modulatory factor for glycolysis, which affect the development and progression of varities of cancers. However, poor attention has been drawn to the role of glycolysis-related lncRNAs in Non-small cell lung cancer(NSCLC) . Methods: The RNA sequencing(RNA-seq) data of NSCLC patients was downloaded from The Cancer Genome Atlas(TCGA) database. Glycolysis-related genes were identified using Gene Set Enrichment Analysis(GSEA). Cox regression analysis was used to construct the glycolysis-related signature. GSEA analysis was used for function assessment. Results: Firstly, a signature consisting of 8 glycolysis-related lncRNAs(AC090559.1, AC099850.3,AL365181.3, AL049555.1, AC024075.3, LINC01843, ATP13A4-AS1 and LINC01133)were estimated. Moreover, on the basis of this signature, we found that overall survival(OS) in high-risk group was markedly lower than that in low-risk group, and the prognostic prediction accuracy was further verified by Multi-parameter ROC curve analysis. Lastly, the 8 glycolysis-related lncRNAs were found to be closely associated with many cancer-related pathways. Conclusion: The 8 glycolysis-related lncRNAs could be promising prognostic and potential therapeutic targets for NSCLC.
Visual Classification of Three Computed Tomography Lung Patterns to Predict Prognosis of COVID-19: A Retrospective Study
Authors: Yamada Daisuke , Ohde Sachiko , Ikejima Kengo , Matsusako Masaki , Kurihara Yasuyuki 
Published: August 2021

Abstract
Background: Quantitative evaluation of radiographic images has been developed and suggested for the diagnosis of coronavirus disease 2019 (COVID-19). However, there are limited opportunities to use these image-based diagnostic indices in clinical practice. Our aim in this study was to evaluate the utility of a visually-based classification of pulmonary findingsfrom computed tomography (CT) images among COVID-19 patients that we developed, with the following three patterns defined: peripheral, multifocal, and diffuse findings of pneumonia. We also evaluated the prognostic value of this classification to predict the severity of COVID-19. Methods: This was a single-center retrospective cohort study of patients hospitalized with COVID-19 between January and September 2020, who presented with suspicious findings on CT lung images (n=69). We compared the association between the three predefined patterns (peripheral, multifocal, and diffuse) and admission to the intensive care unit, tracheal intubation, and death. The following demographic and clinical variables were compared between the three groups: sex, age, respiratory rate, pulse rate, blood pressure, temperature, oxygen saturation, partial pressure of oxygen, white blood cell count, lymphocyte count, neutrophil count, c-reactive protein, lactate dehydrogenase, Krebs von den Lungen-6 antigen, D-dimer, platelet count, steroid administration, heparin administration, favipiravir administration, Acute Physiology and Chronic Health Evaluation-II score, and sequential organ failure assessment score.Results: Patients with a diffuse pattern were intubated more frequently and for a longer duration than patients with a peripheral or multifocal pattern. The following clinical variables were significantly different between the diffuse pattern and peripheral and multifocal groups: body temperature, lymphocyte count, neutrophil count, c-reactive protein, lactate dehydrogenase, Krebs von den Lungen-6 antigen, D-dimer, and steroid and Avigan administration.Conclusions: Our simple visual assessment of CT images can predict a systemic cytokine storm, a resulting decrease in respiratory function, and the need for supplemental respiratory ventilationamong patientswith COVID-19.
Prone Versus Supine Position in Intubated COVID-19 Patients With ARDS: A Systematic Review and Meta-Analysis
Authors: Aditianingsih Dita , Sugiarto Adhrie , Manggala Sidharta Kusuma , Angkasa Hansen , Natanegara Ahmad Pasha 
Published: August 2021

Abstract
BackgroundThis review determined the effect of prone positioning in changes of partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio, partial pressure of carbon dioxide (PaCO2), mortality rate, ICU length of stay and duration of mechanical ventilation in intubated COVID-19 patients with severe ARDS.MethodsA computer-aided comprehensive electronic bibliographic search from MEDLINE, EMBASE, and Science Direct were conducted. The search comprised the articles written in English and intubated adults (≥ 18 years old) patients with COVID-19. The primary outcome was comparing PaO2/FiO2 ratio between prone and supine position group. Secondary outcomes were PaCO2, ICU discharge, and mortality rate. Review Manager version 5.4 (The Cochrane Collaboration) was used for statistical analyses of the included studies.ResultsA total of 7 articles were determined to be eligible, consisting of 1403 intubated COVID-19 patients with ARDS that showed prone position was associated with a higher PaO2/FiO2 ratio compared to supine position (MD 60.17, 95% CI 46.86 - 73.47; p < 0.00001). Four studies reported the PaCO2 measurement and showed no significant difference between prone and supine position (MD 2.07, 95% CI -2.79 - 6.92; p <0.40). Only two studies reported mortalities, one study had 262 deaths out of 648 patients (40.4%) and one study lost 11 out of 20 patients (55%). One study reported median ICU stay and mechanical ventilation duration (16 days) were significantly longer in prone position group.ConclusionThis meta-analysis showed that prone position improved PaO2/FiO2 ratio in intubated COVID-19 patients with ARDS.