bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forgoing plans for alcohol and cannabis use in daily life: Examining reasons for nonuse when use was planned in a predominantly white college student sample
Authors: Stevens Angela K. , Blanchard Brittany E. , Sokolovsky Alexander W. , Gunn Rachel L. , White Helene R. , Jackson Kristina M. 
Published: November 2021

AbstractBackgroundThe reasons for college students to abstain from alcohol and cannabis use on a given day can inform efforts to prevent or intervene in those behaviors. Research on reasons for alcohol nonuse remains in its nascent stages and no study to date has examined reasons for cannabis nonuse on a given day. Here we examine reasons for nonuse among college students after they planned to use alcohol and/or cannabis.MethodsCollege students (N = 341; Mage = 19.79; 53% women; 74% White) from 3 universities completed 54 days of data collection across which approximately 50% were nonuse days. Each morning, participants indicated whether they planned to use that day; nonuse reasons were assessed the next morning, if applicable. Generalized linear mixed‐effects models were used to disentangle within‐ and between‐person effects.ResultsOn a given nonuse day (at the within‐person level), “work” and “school” were reasons associated with having no plan to use alcohol and “to feel in control” was linked to having no plan to use cannabis. “Did not want to get high” was related to forgoing plans (did not use when originally planned) for alcohol use at the within‐person level. At the between‐person level, “no desire” was associated with no plans for alcohol or cannabis use and “did not want to get high” was related to no plans for cannabis use. “School” and “could not get” were related to forgoing plans for alcohol and cannabis use, respectively, at the between‐person level.ConclusionAn examination of earlier intentions for alcohol and/or cannabis use on nonuse days yielded novel findings on the intention–behavior gap. Reasons for nonuse can inform intervention and prevention strategies (e.g., those involving social norms or just‐in‐time adaptive efforts) for alcohol and cannabis use on college campuses.
The seasonally dry tropical forest species Cavanillesia chicamochae has a middle Quaternary origin
Authors: Bacon Christine D. , Gutiérrez‐Pinto Natalia , Flantua Suzette , Castellanos Suárez Diego , Jaramillo Carlos , Pennington R. Toby , Antonelli Alexandre 
Published: November 2021

AbstractWe use DNA sequence data to understand the evolutionary history of the genus Cavanillesia (Malvaceae), with particular emphasis on C. chicamochae, an emblematic succulent‐trunked tree endemic to seasonally dry tropical forests (SDTFs) of the Chicamocha Canyon of Colombia, South America. Based on field sampling of multiple individuals from different populations, we inferred a phylogeny calibrated into absolute time using robust macrofossil information. We show strong support for a monophyletic Cavanillesia chicamochae, with a mean stem age of 1.46 Ma. Two different mechanisms could explain its origin, either a late uplift age of the eastern cordillera or increased dryness of the Chicamocha Canyon during the Middle Pleistocene Transition. We also find marked genetic differentiation of its populations within the Chicamocha Canyon, likely driven by a combination of climate change and local landscape processes. Our results suggest that within northern inter‐Andean SDTFs, as has been demonstrated in the central Andes, dispersal limitation leads to species and even population monophyly within individual valleys. The genetic differentiation of populations of C. chicamochae, together with the presence of other endemic and threatened species in the Chicamocha Canyon, calls for urgent management to conserve the unique biodiversity in the region.Abstract in Spanish is available with online material.
Empirical Evidence for Extended Cognitive Systems
Authors: Favela Luis H. , Amon Mary Jean , Lobo Lorena , Chemero Anthony 
Published: November 2021

AbstractWe present an empirically supported theoretical and methodological framework for quantifying the system‐level properties of person‐plus‐tool interactions in order to answer the question: “Are person‐plus‐tool‐systems extended cognitive systems?” Nineteen participants provided perceptual judgments regarding their ability to pass through apertures of various widths while using visual information, blindfolded wielding a rod, or blindfolded wielding an Enactive Torch—a vibrotactile sensory‐substitution device for detecting distance. Monofractal, multifractal, and recurrence quantification analyses were conducted to assess features of person‐plus‐tool movement dynamics. Trials where people utilized the rod or Enactive Torch demonstrated stable “self‐similarity,” or indices of healthy and adaptive single systems, regardless of aperture width, trial order, features of the participants’ judgments, and participant characteristics. Enactive Torch trials exhibited a somewhat greater range of dynamic fluctuations than the rod trials, as well as less movement recurrence, suggesting that the Enactive Torch allowed for more exploratory movements. Findings provide support for the notion that person‐plus‐tool systems can be classified as extended cognitive systems and a framework for quantifying system‐level properties of these systems. Implications concerning future research on extended cognition are discussed.
Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS‐441524 in patients with COVID‐19: A limited case series
Authors: Choe Pyoeng Gyun , Jeong Sae Im , Kang Chang Kyung , Yang Liju , Lee SeungHwan , Cho Joo‐Youn , Han Seung Seok , Kim Dong Ki , Lee Sang Min , Park Wan Beom , Oh Myoung‐don , Kim Nam Joong 
Published: November 2021

AbstractRemdesivir, an antiviral agent for the treatment of coronavirus disease 2019 (COVID‐19), is metabolized intracellularly, with these metabolites eliminated predominantly in urine. Because of a lack of safety and pharmacokinetic (PK) data, remdesivir is not currently recommended for patients with estimated glomerular filtration rate less than 30 ml/min/1.73 m2 and those on hemodialysis. This study evaluated the PKs of remdesivir and its metabolite, GS‐441524, in patients with COVID‐19 who were and were not receiving renal replacement therapy (RRT). This study enrolled two patients with normal renal function, two with impaired renal function not receiving RRT, two receiving continuous RRT (CRRT), and three undergoing intermittent hemodialysis (IHD). Patients were administered 200 mg remdesivir on the first day, followed by 100 mg/day for 5–10 days. Serial blood samples were collected for PK analysis, and PK parameters were assessed by a noncompartmental method. Systemic exposure to remdesivir was higher in patients with impaired renal function and those receiving CRRT than in patients with normal renal function, but was similar in patients undergoing IHD and those with normal renal function. By contrast, systemic exposure to GS‐441524 was highest in patients undergoing IHD, followed by patients with impaired renal function and those receiving CRRT, and lowest in patients with normal renal function. The PK profiles of remdesivir and GS‐441524 varied according to renal function and RRT. The impact of PK changes of remdesivir and its metabolite on safety and efficacy should be considered when administering remdesivir to patients with COVID‐19 with renal impairment.
Dynamics of managerial power and CEO compensation in the course of corporate distress: Evidence from 1992 to 2019
Authors: Guo Sheng , Kang Qiang , Mitnik Oscar A. 
Published: November 2021

AbstractWe study the dynamics of two governance constructs, managerial influence over the board of directors and chief executive officer (CEO) compensation, in firms undergoing distress during 1992–2019. Data show a clear trend that governance improves over time, which confounds the inference about the effects of distress on governance. Controlling for the secular changes with a bias‐corrected matching estimator, we find that distressed firms reduce managerial board appointments and CEO pay, intensify managerial incentive alignment, and increase CEO turnover. The bulk of CEO compensation changes in distressed firms derives from the performance‐related part of compensation, consistent with the “shareholder value” view of CEO compensation.
Involvement of adolescent representatives and coresearchers in mental health research: Experiences from a research project
Authors: Viksveen Petter , Cardenas Nicole E. , Ibenfeldt Maya , Meldahl Laia G. , Krijger Lou , Game Julia R. , Andvik Maren McLean , Cuddeford Oliver , Duerto Samuel , Mustafa Murad , Tong Mathias 
Published: November 2021

AbstractIntroductionIn spite of adolescents' rights to be involved in decisions that concern their health and life, limited research has been published reporting on their involvement in mental health research. Therefore, we aim to present experiences and reflections based on the involvement of adolescents in mental health research, to describe the collaborative relationship between researchers and coresearchers, including the values that underpin their collaboration.MethodsAn autoethnographic approach was used, combined with group reflections. The process was jointly developed, carried out and analysed by adolescent coresearchers and the project's lead researcher over a period of 2 years. The article is jointly authored by the researcher and the ten coresearchers.ResultsSix themes were developed to describe our collaborative relationship, resulting in the involvement of adolescents in decisions about research priorities; in planning and carrying out the research; through to analysis, dissemination and communication of results. The themes include: (1) Commitment motivated by altruism, personal interests and a common purpose; (2) Inclusiveness and support to reduce social uncertainty and strengthen collaboration; (3) Reduced power differentials while ensuring clarity of roles and tasks; (4) Diversity in representation to expand the perspectives of ‘the adolescent voice’; (5) Self‐determination—supporting adolescents' involvement in decision‐making processes; and (6) Flexible and systematic project management. The themes describe the collaboration, the underlying values and motives, the challenges faced and how they were overcome.ConclusionThis self‐reflective process describing a 4‐year collaborative research project resulted in the development of recommendations for involving adolescents in mental health research. The recommendations could potentially contribute to a change of ‘research culture’ to expand the currently limited involvement of adolescents in research.Patient or Public ContributionAdolescents have contributed as coresearchers through all phases of the research project and as coauthors of this article, including planning, participation in the self‐ and group‐reflective processes, analysis and authoring the article.
Model‐based solution approach for a short‐term flight rescheduling problem in aerial passenger transportation to maritime units
Authors: De La Vega Jonathan , Santana Mateus , Pureza Vitória , Morabito Reinaldo , Bastos Yan , Ribas Paulo César 
Published: November 2021

AbstractThis paper addresses the problem faced by a Brazilian oil and gas company of recovering flights for passenger transportation (mainly teams of employees) to maritime units. Due to unexpected events such as bad weather or aircraft mechanical failures, the original timetable very often cannot be fully met, resulting in flight delays on the same day or even postponements to the following days. As a result, the operation of the maritime units and the scheduling of employee shifts are affected to some extent. Based on a case study conducted at the company, we present a detailed continuous‐time mixed‐integer programming model that aims to include pending flights in the daily scheduling of an aerodrome with a minimum overall delay and usage of aircraft (helicopters), subject to flights with different rescheduling priorities, aerodrome and aircraft time windows, single runways at the aerodrome and single landing spots at each maritime unit, postponement and shift regulations, heterogeneous fleet of helicopters, mandatory stops for the crew to rest and have lunch, among others. We also present a discrete‐time simplification of the former model and some simple solution approaches based on these models in order to cope with larger problem instances. The approach performance is assessed using real‐life problem instances whose data were collected in the case study, using a general‐purpose optimization software. The results show the potential of these approaches in dealing with this short‐term flight rescheduling problem.
An improved procedure for isolating adult mouse cardiomyocytes for epicardial activation mapping
Authors: Zhang Ziguan , Zheng Wuyang , He Dehua , Hu Zichao , Xie Qiang , Huang Meirong , Li Weihua , Huang Zhengrong 
Published: November 2021

AbstractCardiovascular disease is a leading cause of death and disability worldwide. Although genetically modified mouse models offer great potential for robust research in vivo, in vitro studies using isolated cardiomyocytes also provide an important approach for investigating the mechanisms underlying cardiovascular disease pathogenesis and drug actions. Currently, isolation of mouse adult cardiomyocytes often relies on aortic retrograde intubation under a stereoscopic microscope, which poses considerable technical barriers and requires extensive training. Although a simplified, Langendorff‐free method has been used to isolate viable cardiomyocytes from the adult mouse heart, the system requires enzymatic digestions and continuous manual technical operation. This study established an optimized approach that allows isolation of adult mouse cardiomyocytes and epicardial activation mapping of mouse hearts using a Langendorff device. We used retrograde puncture through the abdominal aorta in vivo and enzymatic digestion on the Langendorff perfusion device to isolate adult mouse cardiomyocytes without using a microscope. The yields of isolated cardiomyocytes were amenable to patch clamp techniques. Furthermore, this approach allowed epicardial activation mapping. We used a novel, simplified method to isolate viable cardiomyocytes from adult mouse hearts and to map epicardial activation. This novel approach could be beneficial in more extensive research in the cardiac field.
Efficacy of rehabilitation of stage IV periodontitis patients with full‐arch fixed prostheses: Tooth‐supported versus Implant‐supported—A systematic review
Authors: Tomasi Cristiano , Albouy Jean‐Pierre , Schaller Dennis , Navarro Renata Camino , Derks Jan 
Published: November 2021

AbstractObjectivesTo evaluate the efficacy of implant‐supported in comparison to tooth‐supported full‐arch prostheses in patients with stage IV periodontitis.Materials and MethodsSystematic electronic search (CENTRAL/MEDLINE/SCOPUS) up to March 2020 was conducted to identify randomized controlled trials and cohort‐like studies comparing/evaluating fixed full‐arch rehabilitation on teeth or implants in patients with stage IV periodontitis. The primary outcome measure was loss of teeth/implants and restorations. Data extraction was performed to create evidence tables, and meta‐analyses were carried out as appropriate.ResultsA total of 26 studies (31 publications) were identified but none addressed the scientific question in a controlled and randomized design. The risk of bias throughout the included studies was judged to be high, and meta‐analyses demonstrated a high degree of heterogeneity. Mean‐weighted observation periods in studies on tooth‐supported restorations were significantly longer than in studies on implant‐supported restorations. The predicted loss of teeth and tooth‐supported full‐arch restorations over 10 years was 1% and 5%, respectively. The 15‐year estimates were 10% and 13%. Corresponding predictions for implants and implant‐supported restorations for 10 years amounted to 4% and 6%, respectively. Technical complications were the most commonly reported and affected 8% of tooth‐supported restorations (during 7.2 years) and 42% of implant‐supported structures (during 2.6 years). Peri‐implantitis‐ or peri‐implantitis‐like symptoms were observed at an estimated 9% of implants (after 3.1 years).ConclusionsBased on observational studies on full‐arch rehabilitation of stage IV periodontitis patients, 10‐year estimates of tooth loss were lower than the corresponding estimates for implants. Estimated loss of tooth‐ and implant‐supported restorations at 10 years was similar. Technical complications were more prevalent at implant‐supported when compared to tooth‐supported restorations.
Implementation of clinical practice guidelines for low back pain: A case control cohort study of knowledge translation in a multi‐site healthcare organization
Authors: Kolb William H. , Bade Michael J. , Bradberry Caleb 
Published: November 2021

AbstractRationaleThe benefits of clinical practice guideline (CPG) adoption for the management of patients with back pain are well documented. However, the gap between knowledge creation and implementation remains wide with few studies documenting the iterative process of comprehensive implementation in clinical settings. The objective of this study was to improve adherent physical therapy care according to CPG's for low back pain and describe the knowledge to action (K2A) process used in a rural healthcare organization.MethodsA prospective case control cohort design was used to evaluate physical therapy provider practice changes during an 18 month intervention. Four clinical sites were selected, two of which received multifaceted educational and process interventions tailored to feedback from ongoing K2A cycle outcomes. Overall program assessment included monthly charge code reports for adherence and a pre‐post survey of confidence for guideline use. Pragmatic Reach‐Effectiveness‐Adoption‐Implementation‐Maintenance (RE‐AIM) criteria were used to complete the process evaluation.ResultsA significant difference (p < 0.001, mean difference 13.5, CI [8.5,18.5]) for charge code adherence favoured education site‐1 over control site‐2 after implementation. Adherence scores remained above target at both education sites 18 months after implementation. Survey differences were significant for confidence scores at education sites in use of the cognitive behavioural category, overall treatment category use and guideline communication. Process evaluation supported multifaceted interventions tailored to education sites with average cost measured by staff education time of 15.5 h per therapist trained.ConclusionThis study extends the literature of guideline implementation by describing the unique cycles required for promoting provider behaviour change within a rural healthcare system. Adherence and confidence results suggest increased provider CPG use which was supported by the process evaluation. This study demonstrates the importance of multiple site comparisons, long‐term reporting and standardized frameworks for assessment of real‐world CPG implementation.
Acquisition of cognitive and communication milestones in infants with Down syndrome
Authors: Onnivello S. , Schworer E. K. , Daunhauer L. A. , Fidler D. J. 
Published: November 2021

AbstractBackgroundUnderstanding the timing of developmental milestones in typical and clinical populations facilitates intervention planning and the early detection of risk for co‐occurring conditions. Normative timing of developmental milestone achievement has been established for typically developing children. However, there is little information regarding the timing of cognitive and communication skill acquisition in young children with Down syndrome (DS). The objectives of this study are to (1) provide foundational information regarding the timing of cognitive and communication skill acquisition in infants with DS and (2) facilitate the early identification of infants with risk for co‐occurring conditions.MethodSeventy‐four infants with DS (age range: 4–18 months) completed the Bayley Scales of Infant Development‐III (Bayley 2006). Individual items from the cognitive and communication scales were selected for analysis. Parents provided information regarding their infant's developmental and family history.ResultsThe percentage of infants who attained each skill was calculated within 2‐month age bands. For infants who did not show skill acquisition within each age band, the rates of prematurity, heart defects, corrective heart surgery and significant illness were calculated as well.ConclusionsThis study provides foundational information that can contribute to the formulation of a developmental schedule for cognitive and language milestone acquisition in infants with DS.
Plastination of a sperm whale
Authors: Jiang Wen‐Bin , Han Jian , Ma Xue‐Wei , Liu Hu , Yu Sheng‐Bo , Sui Hong‐Jin 
Published: November 2021

AbstractIn 2016, two adult male sperm whales beached off of Yangkou Port in Nantong City, Jiangsu Province, China. The local government planned to preserve them as specimens, one was entrusted to Dalian Hoffen Biological Co., Ltd., and thus became the first sperm whale to be preserved by plastination. The other sperm whale was preserved in Nantong by the traditional stripping method (The skin was preserved, and then the prosthesis was filled into the skin to preserve the specimens. The material of the prosthesis was polyurethane. The outline of the animal was sculpted by suturing the skin like a bag and filling it with polyurethane). Plastination of such a large marine mammal allowed us to view the mutual adaptations of its internal structure to its specific living environment and daily habits. This sperm whale is the largest specimen in the world and this is the first time a sperm whale has been preserved using the plastination method. The plastination process also provides a method for studying the anatomy of large marine mammals for humans to understand deep‐sea organisms at close contact and visual level. The plastination of this sperm whale promises to be a world class resource holding tremendous scientific, educational, and artistic value.