bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIMULATION OF THE ROTATIVE-TRANSLATIVE MOTION OF THE DUMBBELL, WHEN THE CENTER OF ITS MASS MOVES IN A CIRCLE
Authors: Leonid Kutsenko  , Andrii Kalynovskyi  , Oleksandr Polivanov  , Andrii Cherniavskyi  , Leonid Zapolskyi  
Published: October 2021

A geometric model of the rotational-translational motion of a dumbbell in a central force field is proposed, provided that its center of mass moves in a circle of a given radius. The term dumbbell denotes a geometric object with two masses spaced apart at a certain distance, connected by a weightless rod (like a sports dumbbell). The idea of modeling is based on the compilation and solution of a system of Lagrange differential equations of the second kind. To compose the equations, the Lagrangian was used to describe the rotational-translational motion of a dumbbell in a central force field. The system of equations is formed with respect to five functions denoting five generalized coordinates. These coordinates connect the fixed and mobile coordinate systems that provide the rotational-translational movement of the dumbbell. The system of Lagrange differential equations of the second kind was solved numerically in the environment of the maple mathematical processor. The results obtained correspond to each of five different coordinate functions that can be plotted graphically. Also obtained are approximate descriptions of the derivatives of these functions depending on the parameters of the dumbbell and the initial conditions of its motion. These results made it possible to construct graphs of phase trajectories of functions of five coordinate coordinates, with the help of which it is possible to determine the nature of the dumbbell movement. The obtained time dependences for the functions of generalized coordinates make it possible to compose an algorithm for computer animation of the rotational-translational motion of the dumbbell. In this case, the parameters of the dumbbell and the initial conditions of its movement will be taken into account. Examples of modeling the trajectories of the centers of mass of the dumbbell weights are given. It is advisable to use the results obtained to illustrate the position of the dumbbell in space when studying its orbital dynamics. Computer animations of a dumbbell movement in zero gravity will make it possible to analyze the influence of the angular velocities of rotation on its movement. At this stage of research, it is advisable to use the results obtained as the basis for laboratory or coursework of the departments of geometric modeling and computer graphics.
Вплив регуляторів росту рослин на ріст і масу сіянців дуба звичайного у Південно-східному Лісостепу України
Authors: Danylenko O. M. , Vysotska N. Yu. , Tarnopilsky P. B. , Rumiantsev M. Н. 
Published: October 2021

Наведено результати досліджень впливу регуляторів росту рослин на біометричні показники та масу однорічних сіянців дуба звичайного (Quercus robur L.) із закритою кореневою системою. Сіянці вирощено в контейнерах із агроволокна в умовах відкритого ґрунту. Виявлено, що під час передвисівної обробки жолудів найефективнішими є варіанти застосування «Агростимуліну» у концентрації 8 мл·л-1, «Чаркору» – 4 мл·л-1 та «Триману-1» – 150 мг·л-1. Найбільший позитивний вплив на біометричні показники та масу однорічних сіянців під час вирощування (трикратне підживлювання сіянців регуляторами росту рослин упродовж вегетаційного періоду) відзначено у варіантах, де застосовували «Мегафол» у концентрації 1 мл·л-1 та «Радіфарм» – 2,5 мл·л-1. Результати проведених досліджень свідчать про доцільність застосування досліджуваних регуляторів росту рослин під час вирощування сіянців дуба звичайного із закритою кореневою системою в умовах відкритого ґрунту та подальшого їхнього використання під час лісовідновлення й лісорозведення в Південно-східному Лісостепу України.
Intellectual property rights in research and development collaboration/ contract agreements between research institutions, universities and firms: part 1 — European Union, US
Authors: Kapitsa Yurii 
Published: October 2021

Keywords: research and development contracts, research and development collaborationagreements, intellectual property rights, research organisations, universities
The practice of regulating intellectualproperty relations in R&D cooperation agreements / R&D contracts between researchinstitutions, universities (academic institutions) and companies in the EU, USA, aswell as in the recommendations of international organizations is studied.It is noted the significant role given in the EU, the USA to the settlement of IP issuesin R&D agreements. It is shown, that the development of model agreements inthe United States is carried out mainly at the university level. In the EU it is significantthe role of the European Commission, national government bodies in the developmentof the agreements.The principal provisions of IP regime in the R&D agreements are noted, which include:identification of Background IP and New IP. Granting Background IP rightsusually on the basis of a non-exclusive royalty license. Consolidation of New IP rightsfor academic institutions. Granting New IP rights on royalty-based licences or paidtransfer of rights.It is noted the importance of possibility of restitution of IP property rights to academicinstitution if the company does not commercialize the granted IP. Also, of the assignmentof IP rights to academic institutions for research and training purposes incases of granting exclusive licenses and transferring property rights.The principles of distribution of intellectual property rights and use of research resultsin R&D agreements are determined, which should be applied in the practice ofconcluding corresponding agreements in Ukraine. Amendments to the Law ofUkraine “On Scientific and Scientific-Technical Activity” are proposed to provide forthe indication of the types of R&D agreements, as well as the principles of using IP inagreements.
Manifesto for Digital Social Touch in Crisis
Authors: Jewitt Carey , Price Sara , Steimle Jürgen , Huisman Gijs , Golmohammadi Lili , Pourjafarian Narges , Frier William , Howard Thomas , Ipakchian Askari Sima , Ornati Michela , Panëels Sabrina , Weda Judith 
Published: October 2021

This qualitative exploratory research paper presents a Manifesto for Digital Social Touch in Crisis - a provocative call to action to designers, developers and researchers to rethink and reimagine social touch through a deeper engagement with the social and sensory aspects of touch. This call is motivated by concerns that social touch is in a crisis signaled by a decline in social touch over the past 2 decades, the problematics of inappropriate social touch, and the well documented impact of a lack of social touch on communication, relationships, and well-being and health. These concerns shape how social touch enters the digital realm and raise questions for how and when the complex space of social touch is mediated by technologies, as well the societal implications. The paper situates the manifesto in the key challenges facing haptic designers and developers identified through a series of interdisciplinary collaborative workshops with participants from computer science, design, engineering, HCI and social science from both within industry and academia, and the research literature on haptics. The features and purpose of the manifesto form are described, along with our rationale for its use, and the method of the manifesto development. The starting points, opportunities and challenges, dominant themes and tensions that shaped the manifesto statements are then elaborated on. The paper shows the potential of the manifesto form to bridge between HCI, computer science and engineers, and social scientists on the topic of social touch.
Malnutrition and Risk of Procedural Complications in Patients With Atrial Fibrillation Undergoing Catheter Ablation
Authors: Kim Daehoon , Shim Jaemin , Kim Yun Gi , Yu Hee Tae , Kim Tae-Hoon , Uhm Jae-Sun , Choi Jong-Il , Joung Boyoung , Lee Moon-Hyoung , Kim Young-Hoon , Pak Hui-Nam 
Published: October 2021

Background: Little is known about the prognostic value of nutritional status among patients undergoing atrial fibrillation (AF) catheter ablation (AFCA). We compared the risk of procedure-related complications and long-term rhythm outcomes of AFCA according to nutritional status.Methods: We included 3,239 patients undergoing de novo AFCA in 2009-2020. Nutritional status was assessed using the controlling nutritional status (CONUT) score. The association between malnutrition and the risk of AFCA complications or long-term rhythm outcomes was evaluated. We validated the effects of malnutrition using an external cohort of 360 patients undergoing AFCA in 2013-2016.Results: In the study population (26.8% women, median age: 58 years), 1,005 (31.0%) had malnutrition (CONUT scores ≥ 2); 991 (30.6%) had mild (CONUT 2–4) and 14 (0.4%) had moderate-to-severe (CONUT ≥ 5) malnutrition. The overall complication rates after AFCA were 3.3% for normal nutrition, 4.2% for mild malnutrition, and 21.4% for moderate-to-severe malnutrition. Moderate-to-severe malnutrition [odds ratio (OR) 6.456, 95% confidence interval (CI) 1.637-25.463, compared with normal nutrition], older age (OR 1.020 per 1-year increase, 95% CI 1.001-1.039), female sex (OR 1.915, 95% CI 1.302-2.817), and higher systolic blood pressure (OR 1.013 per 1-mmHg increase, 95% CI 1.000-1.026) were independent predictors for the occurrence of complications. In the validation cohort, malnutrition (CONUT ≥ 2) was associated with a 2.87-fold higher risk of AFCA complications (95% CI 1.174-7.033). The association between malnutrition and a higher risk of AFCA complications was consistently observed regardless of body mass index and sex. Malnutrition did not affect rhythm outcomes during the median follow-up of 40 months (clinical recurrence: 37.0% in normal nutrition vs. 36.5% in malnutrition).Conclusion: Malnutrition, which is common in patients undergoing AFCA, was associated with a substantially higher risk for complications after AFCA.
The Clinical Significance and Immunization of MSMO1 in Cervical Squamous Cell Carcinoma Based on Bioinformatics Analysis
Authors: Zheng Guangfei , Wang Zhuan , Fan Yuchun , Wang Tian , Zhang Linli , Wang Mengling , Chen Su , Jiang Lihe 
Published: October 2021

Objective: The genetic markers for the detection or treatment of cervical squamous cell carcinoma (CESC) are not yet complete. This study aimed to identify the role of MSMO1 (Alternative name: SC4MOL) in the occurrence and development of CESC.Methods: We evaluated the significance of MSMO1 expression in CESC by using analysis of a public dataset from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. Oncomine and GEPIA2 were used to validate MSMO1 as an independent prognostic factor in CESC. Multiple tools were used to analyze the factors and functions associated with MSMO1, such as methylation, miRNA, and co-expressed genes. Furthermore, TIMER and TISIDB were used to study the relationship between MSMO1 expression and immunization in CESC.Results: MSMO1 was highly expressed in tumor specimens and could be used as an independent prognostic factor of CESC (p &lt; 0.05). But Casiopeinas chemotherapeutics and p63 loss could reduce the expression of MSMO1. The level of methylation MSMO1 was significantly increased in tumor tissues but there was an insignificant effect on the prognosis. MSMO1 was also closely related to hsa-miR-23a-3p, hsa-miR-23b-3p, hsa-miR-130b-3p, and gene IDI1. Specifically, the expression level of MSMO1 had a significant negative correlation with the infiltration level of CD4+T cells, Macrophages, Neutrophils, and DCs in CESC. In addition, GSEA identified differential enrichment in systemic lupus erythematosus, vascular smooth muscle contraction, cytokine receptor interaction, focal adhesion, chemokine signaling pathway, and Leishmania infection pathway in KEGG.Conclusion: Our findings provide evidence of the implications of MSMO1 in tumors, suggesting that MSMO1 is a promising prognostic biomarker in CESC.
Clinical Immunogenicity Evaluation of Eptinezumab, a Therapeutic Humanized Monoclonal Antibody Targeting Calcitonin Gene-Related Peptide (CGRP) for the Preventive Treatment of Migraine
Authors: Pederson Susan , Biondi David M. , Allan Brent , Cady Roger , Schaeffler Barbara , Baker Brian , Latham John 
Published: October 2021

BackgroundEptinezumab is a humanized monoclonal antibody that selectively binds calcitonin gene-related peptide and is indicated for the preventive treatment of migraine in adults. This analysis characterizes the immunogenic profile of eptinezumab using data from clinical trials of eptinezumab for migraine prevention.MethodsImmunogenicity data were collected from five studies that included 2076 patients with episodic or chronic migraine treated with eptinezumab at dose levels ranging from 10 to 1000 mg, administered intravenously for up to 4 doses at 12-week intervals. Anti-drug antibody (ADA) results were available from 2074 of these patients. Four studies were randomized, double-blind, placebo-controlled trials with ADA monitoring for up to 56 weeks; one was a 2-year, open-label, phase 3 safety study with ADA monitoring for 104 weeks. Patients who had a confirmed ADA-positive result at the end-of-study visit were monitored for up to 6 additional months. Development of ADA and neutralizing antibodies (NAbs) were evaluated to explore three key areas of potential impact: pharmacokinetic exposure profile (eptinezumab trough plasma concentrations), efficacy (change in monthly migraine days), and safety (rates of treatment-emergent adverse events). These studies included methods designed to capture the dynamics of a potential humoral immune response to eptinezumab treatment, and descriptive analyses were applied to interpret the relationship of ADA signals to drug exposure, efficacy, and safety.ResultsPooled across the five clinical trials, treatment-emergent ADAs and NAbs occurred in 15.8 and 6.2% of eptinezumab-treated patients, respectively. Highly consistent profiles were observed across all studies, with initial onset of detectable ADA observed at the week 8 measurement and maximal ADA frequency and titer observed at week 24, regardless of eptinezumab dose level or number of doses. After 24 weeks, the ADA and NAb titers steadily declined despite additional doses of eptinezumab.InterpretationCollectively, these integrated analyses did not demonstrate any clinically meaningful impact from ADA occurring after treatment with eptinezumab. The ADA profiles were low titer and transient, with the incidence and magnitude of ADA or NAb responses declining after week 24. Development of ADAs and NAbs did not impact the efficacy and safety profiles of eptinezumab.
DNA Dye Sytox Green in Detection of Bacteriolytic Activity: High Speed, Precision and Sensitivity Demonstrated With Endolysins
Authors: Harhala Marek , Gembara Katarzyna , Miernikiewicz Paulina , Owczarek Barbara , Kaźmierczak Zuzanna , Majewska Joanna , Nelson Daniel C. , Dąbrowska Krystyna 
Published: October 2021

Introduction: Increasing number of deaths from multi-drug resistant bacterial infections has caused both the World Health Organization and the Centers for Disease Control and Prevention to repeatedly call for development of new, non-traditional antibacterial treatments. Antimicrobial enzymes, including those derived from bacteriophages, known as endolysins or enzybiotics, are considered promising solutions among the emerging therapies. These naturally occurring proteins specifically destroy bacterial cell walls (peptidoglycan) and as such, are capable of killing several logs of bacteria within minutes. Some endolysins cause lysis of a wide range of susceptible bacteria, including both Gram-positive and Gram-negative organisms, whereas other endolysins are species- or even strain-specific. To make wide use of endolysins as antibacterial agents, some basic research issues remain to be clarified or addressed. Currently available methods for testing endolysin kinetics are indirect, require large numbers of bacteria, long incubation times and are affected by technical problems or limited reproducibility. Also, available methods are focused more on enzymatic activity rather than killing efficiency which is more relevant from a medical perspective.Results: We show a novel application of a DNA dye, SYTOX Green. It can be applied in comprehensive, real-time and rapid measurement of killing efficiency, lytic activity, and susceptibility of a bacterial population to lytic enzymes. Use of DNA dyes shows improved reaction times, higher sensitivity in low concentrations of bacteria, and independence of bacterial growth. Our data show high precision in lytic activity and enzyme efficiency measurements. This solution opens the way to the development of new, high throughput, precise measurements and tests in variety of conditions, thus unlocking new possibilities in development of novel antimicrobials and analysis of bacterial samples.
Long Noncoding Competing Endogenous RNA Networks in Pancreatic Cancer
Authors: Xiong Guangbing , Pan Shutao , Jin Jikuan , Wang Xiaoxiang , He Ruizhi , Peng Feng , Li Xu , Wang Min , Zheng Jianwei , Zhu Feng , Qin Renyi 
Published: October 2021

Pancreatic cancer (PC) is a highly malignant disease characterized by insidious onset, rapid progress, and poor therapeutic effects. The molecular mechanisms associated with PC initiation and progression are largely insufficient, hampering the exploitation of novel diagnostic biomarkers and development of efficient therapeutic strategies. Emerging evidence recently reveals that noncoding RNAs (ncRNAs), including long ncRNAs (lncRNAs) and microRNAs (miRNAs), extensively participate in PC pathogenesis. Specifically, lncRNAs can function as competing endogenous RNAs (ceRNAs), competitively sequestering miRNAs, therefore modulating the expression levels of their downstream target genes. Such complex lncRNA/miRNA/mRNA networks, namely, ceRNA networks, play crucial roles in the biological processes of PC by regulating cell growth and survival, epithelial–mesenchymal transition and metastasis, cancer stem cell maintenance, metabolism, autophagy, chemoresistance, and angiogenesis. In this review, the emerging knowledge on the lncRNA-associated ceRNA networks involved in PC initiation and progression will be summarized, and the potentials of the competitive crosstalk as diagnostic, prognostic, and therapeutic targets will be comprehensively discussed.
Psychosocial and Neurobiological Vulnerabilities of the Hospitalized Preterm Infant and Relevant Non-pharmacological Pain Mitigation Strategies
Authors: Shiff Ilana , Bucsea Oana , Pillai Riddell Rebecca 
Published: October 2021

Background:Preterm pain is common in the Neonatal Intensive Care Unit (NICU), with multiple invasive procedures occurring daily.Objective:To review the psychosocial and neurobiological vulnerabilities of preterm infants and to provide an updated overview of non-pharmacological strategies for acute procedural pain in hospitalized preterm infants.Methods:We utilized a narrative review methodology, which also included a synthesis of key pieces of published systematic reviews that are relevant to the current work.Results and Conclusions:Preterm infants are uniquely susceptible to the impact of painful procedures and prolonged separation from caregivers that are often inherent in a NICU stay. Non-pharmacological interventions can be efficacious for mitigating procedural pain for preterm infants. Interventions should continue to be evaluated with high quality randomized controlled trials, and should endeavor to take into account the neurobiological and psychosocial aspects of preterm vulnerability for pain prevention and management strategies.
Concentration-Dependent Decitabine Effects on Primary NK Cells Viability, Phenotype, and Function in the Absence of Obvious NK Cells Proliferation–Original Article
Authors: Li Xiang , Zhang Min , Cai Sisi , Wu Yaohui , You Yong , Wang Xianghong , Wang Li 
Published: October 2021

Acute myeloid leukemia (AML) cells can evade innate immune killing by modulating natural killer (NK) cells receptors and their cognate ligands in tumor cells, thus it may be possible to restore proper expression of immune receptors or ligands with immune sensitive drugs. Decitabine, as a hypomethylation agent, was approved for the treatment of AML and myelodysplastic syndrome. While clinical responses were contributed by epigenetic effects and the induction of cancer cell apoptosis, decitabine also has immune-mediated anti-tumor effects. After exposure to various concentration of decitabine for 24 h, the primary NK cells (AML-NK cells) cytotoxicity and receptor expression (NKG2D and NKp46) displayed parabola-shaped response, while U-shaped response was seen in cytokine release (IFN-γ and IL-10), and these effects were regulated by ERK and STAT3 phosphorylation level. Furthermore, AML-NK cells function displayed different response when the competitive MEK and STAT3 inhibitors applied respectively. Thus, we could conclude that the different dose of decitabine makes various effects on AML-NK cells function and receptors expression.
Are Different Types of Learning Disorder Associated With Distinct Cognitive Functioning Profiles?
Authors: Brandenburg Janin , Huschka Sina S. , Visser Linda , Hasselhorn Marcus 
Published: October 2021

Introduction: DSM-5 presented a revised conceptualization of specific learning disorders (LD). Contrary to former versions, the various types of LD—i.e., mathematics disorder, reading disorder, and writing disorder—are not treated as distinct diagnostic entities but are integrated into one single LD category. In support of this new classification, it has been argued that the various types of LD overlap to a great extent in their cognitive functioning profiles and therefore do not exhibit a distinct set of cognitive causes. In contrast, ICD-11 still adheres to the idea of discrete categories and thus follows the specificity hypothesis of LD. Using latent profile analysis (LPA), we therefore tested the specificity of cognitive strengths and weaknesses in children with different types of LD. Secondly, we aimed at examining the extent to which observed LD characteristics (type and severity of LD as well as IQ-achievement discrepancy) were consistent with the membership of a given latent profile.Method: 302 German third-graders (134 girls; IQ ≥ 85; Mage = 111.05 months; SD = 5.76) with single or comorbid types of LD in the domains of mathematics, reading, and spelling completed a wide range of domain-specific and domain-general cognitive functioning measures.Results: Five qualitative distinct profiles of cognitive strengths and weaknesses were identified. Profile 1 (23% of the sample) showed Comprehensive Cognitive Deficits, performing low in all measures except for naming speed, language, and inhibition. Profile 2 (21%) included children with a Double Deficit in Phonological Awareness and Phonological Short-term Memory. Profile 3 (20%) was characterized by a Double Deficit of Phonological Awareness and Naming Speed. Profile 4 (19%) included children with a Single Deficit in Attention, and profile 5 (17%) consisted of children without any cognitive deficits. Moreover, type and severity of LD as well as IQ-achievement discrepancy discriminated between the profiles, which is in line with the specificity hypothesis of LD.Discussion: Overall, the finding of specific associations between the LD types and the identified cognitive profiles supports the ICD-11 classification of LD. Yet, those inferences may not be valid for an individual child but need to be examined through comprehensive diagnostic.