bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure
Authors: Borges-Júnior Flávio A. , Silva dos Santos Danúbia , Benetti Acaris , Polidoro Juliano Z. , Wisnivesky Aline C.T. , Crajoinas Renato O. , Antônio Ednei L. , Jensen Leonardo , Caramelli Bruno , Malnic Gerhard , Tucci Paulo J. , Girardi Adriana C.C. 
Published: April 2021

Significance Statement
SGLT2 inhibitors represent a class of drugs that were originally developed for improving glycemic control. Cardiovascular outcome trials designed to evaluate cardiovascular safety yielded unexpected and unprecedented evidence of the cardiorenal benefits of SGLT2 inhibitors. Many hypotheses have been proposed to explain the mechanisms underlying these effects. Our study demonstrates that SGLT2 inhibition is associated with the restoration of euvolemia in nondiabetic heart failure (HF) rats by preserving GFR and renal mass and inhibiting proximal tubule NHE3-mediated sodium reabsorption. The attenuation of kidney dysfunction may constitute an essential mechanism by which SGLT2 inhibitors attenuate HF development and progression in either the presence or absence of diabetes.

Background
SGLT2 inhibitors reduce the risk of heart failure (HF) mortality and morbidity, regardless of the presence or absence of diabetes, but the mechanisms underlying this benefit remain unclear. Experiments with nondiabetic HF rats tested the hypothesis that the SGLT2 inhibitor empagliflozin (EMPA) inhibits proximal tubule (PT) NHE3 activity and improves renal salt and water handling.

Methods
Male Wistar rats were subjected to myocardial infarction or sham operation. After 4 weeks, rats that developed HF and sham rats were treated with EMPA or untreated for an additional 4 weeks. Immunoblotting and quantitative RT-PCR evaluated SGLT2 and NHE3 expression. Stationary in vivo microperfusion measured PT NHE3 activity.

Results
EMPA-treated HF rats displayed lower serum B-type natriuretic peptide levels and lower right ventricle and lung weight to tibia length than untreated HF rats. Upon saline challenge, the diuretic and natriuretic responses of EMPA-treated HF rats were similar to those of sham rats and were higher than those of untreated HF rats. Additionally, EMPA treatment prevented GFR decline and renal atrophy in HF rats. PT NHE3 activity was higher in HF rats than in sham rats, whereas treatment with EMPA markedly reduced NHE3 activity. Unexpectedly, SGLT2 protein and mRNA abundance were upregulated in the PT of HF rats.

Conclusions
Prevention of HF progression by EMPA is associated with reduced PT NHE3 activity, restoration of euvolemia, and preservation of renal mass. Moreover, dysregulation of PT SGLT2 may be involved in the pathophysiology of nondiabetic HF.
Technical Strategies Of Selective Fmcg Marketers In India
Authors: Et. al. Dr. r. Karpagavalli, 
Published: April 2021

This study aims at providing a better knowledge of Competitor Intelligence tools & techniques. “CHANGES REMAINS UNCHANGED “is a powerful eye-opener key tool. Since when world becomes Digitalized the marketing research also turned into digital form. A common customer never thinks that how our desired product Avails in the market. But the modern marketer could able to read their customer mind without approaching them directly.. for this magical result one corporate company is reading & observing their rival competitor. This article based on an empirical study of Competitor intelligence tools & techniques strategies towards FMCG marketers of India
Analysis and Visualisation of Research Trends in Nano Material: A General Review
Authors: Kumar Ranvijay 
Published: April 2021

Technically, the material possessing a minimum, one external dimension measuring 1-100nm is called Nanomaterial, and cannot be seen by the naked eye. The bibliometric analysis had been conducted to understand the active authors, organizations, journals, and countries involved in the research domain of “Nanomaterial”[1], [2]. All published articles related to “Nanomaterial” from “Scopus”, were analyzed using the VOS viewer to develop analysis tables and visualization maps.This article had set the objective to consolidate the scientific literature regarding the “Nanomaterial”and also to find out the trends related to the same.The most active journals in this research domain were Construction and Building Materials and Composites Science and Technology. The most active countries were China and the United States of America. The leading organizations engaged in the research regarding Nanomaterial was the Chinese Academy of Sciences, the North Eastern University of China, and the Ministry of Education of China.The most active authors who had made valuable contributions related to Nanomaterial were Wang Y. and Yang H.
Bernstein Type Inequalities for Polar Derivative of Polynomial
Authors: Chanam Barchand 
Published: April 2021

If is a polynomial of degree n such that in , , then Govil [ Proc. Nat. Acad. Sci., Vol. 50, pp. 50-52, 1980. ] proved
provided and attain their maxima at the same point on the circle , where .
Equality in the above inequality holds for.
In this paper, we extend the above inequality and an improved version of this into polar derivative of a polynomial.
Israeli Primary School Teachers' Attitudes towards Using Digital Educational Games in Classroom: Empirical Study
Authors: Shamma Fathi Mohsen 
Published: April 2021

This study investigated the Israeli primary school teachers' attitudes towards using digital educational games in classroom. Through adopting a descriptive analytical approach, the required made sure that the goals of this research. The researcher employed the purposive sampling method for selecting a sample. The selected sample consists from 300female and male primaryIsraeli primary school teachers. Those teachers were selected from 25 primary schools. Those schools are located in the Northern District in Israel. Questionnaire forms were distributed via email to the selected teachers. 288 forms were retrieved. The response rate is 96%. Through the use of the SPSS software, the data collected from the sampled teaches were analysed. The researcher concluded that Israeli primary school teachers show positive attitudes towards using digital educational games in classroom. Such use improves students’ leadership, problem solving and critical thinking skills and raise their self-confidence and academic achievement levels. However, it doesn’t allow instructors to identify the extent of progress achieved by learner. The researcher recommends providing teachers in Israel with professional development courses about modern teaching methods and the significance of employing digital educational games.
A Study on the Challenges Being Faced by Chandigarh University Students and their Parents during Covid-19 Lockdown
Authors: Kanojia Sonika 
Published: April 2021

These days when India is locked down, apart from the economy the hardest thing getting suffered is our students’ education. They were in the midst of their classes or examination when this Covid-19 a coronavirus attacked India. Very wisely the India government took the decision to lockdown whole India in very initial stage. Chandigarh University management announced postponing the exams and immediately asked the students to move to their homes, if possible. This decision was taken one week in advance to the Indian Government decision. It was on 14th of March, 2020 when the management of the University decided the wellbeing of their students and asked them to move back. With this effort, most of the students reached their homes and staying with their parents. In all this set back an emotional support is very necessary. This study was initiated to understand the physical and emotional wellbeing of the students of Chandigarh University. The results found are very positive as most of the students are safe including those who could not leave their hostels because of any reason. They are being taken good care by Chandigarh University Management. In this study, we have tried to find out if the students are facing any challenges and if they are worried for anything. It will support the management to put their best effort forward to make the things even better for the students. The student strength of Chandigarh University belongs to complete India so this study will help all educational institutions to better support their students.
The Failure of the European Union to Respond to the Refugee Crisis
Authors: Et. al. Abdullah Omar Yassen, 
Published: April 2021

Purpose: Recent UNHCR figures show that a record 70.8 million refugees are forcibly displaced. Millions of refugees are trapped in protracted refugee situations, and have been so on average for 25 years; this compares with 17 years in 2003, and nine in 1991. The research addresses whether the existing international refugee law regime is capable of addressing this crisis, or whether the issue is that member states do not comply with the refugee regime
Results: This research highlights the failure of European Union to respond to the refugee problems. The figures show that there are more refugees trapped in protracted situations than before and also that their plight takes longer to be resolved. Therefore, from the perspective of persons born in danger zones, one is more likely to be a refugee in 2019 than in 2014, yet less likely to find a durable solution.
Methodology: The study adopted a doctrinal methodology by exploring legislation and directives to identify whether these laws can address refugee issues.
Novelty/originality of this study: Forced migration has received negative media coverage and politicians, especially right-wing parties, have used migrants as a scapegoat. This paper identifies some of the myths of migration to demonstrate that, if given the opportunity, migrants can contribute positively to economic growth and integrate with local communities
Zhong Yong and moderation of Chinese Muslims in Indonesia
Authors: Et. al. Wahidah Zein Br Siregar, 
Published: April 2021

Chinese Muslims are a minority among Indonesian Muslims and are categorized as moderate Muslims. This research aims to identify the factors which contribute to moderation in this community. Using qualitative analysis, this research found that the classic Chinese philosophy, Confucianism, plays a big role. The concept of Zhong Yong in Confucianism is used by Chinese Muslims in Indonesia as their life philosophy even though many do not really know what it is. Research informants admit that even though they are Muslims, Confucianism is practiced and is well developed in their everyday lives. This is a concept of balance in life and they practice a moderate life in the Indonesian community in three ways: first, by balancing culture and religion through building mosques that are unique to Indonesia. These mosques, which are called Muhammad Cheng Hoo, use Chinese ornamentation. Second, trying to be innovative in the way they present Islam, so that Islamic teaching will be easily understood. Third, taking the middle ground to overcome any conflicts that may happen. Other aspects that are also important in order to understand Indonesian Chinese Muslims are family tradition and their interactions with Indonesians.
Social Capital in Poverty Reduction: A Systematic Literature Review
Authors: Et. al. Adi Syahid M.A, 
Published: April 2021

Poverty reduction is a global issue and it is often associated with economic-based solutions. While most of the times, poverty solution is discussed through economic variables, more recent studies nowadays have started to suggest social capital as the alternative solution to poverty reduction. The present article sets out to analyse the existing literature on social capital and how it can affect poverty level of a household. PRISMA Statement (Preferred Reporting Items for Systematic reviews and Meta-Analyses) as a review method, a systematic review was done on 10 databases where it had identified 472 relevant studies. Through the review, social capital was commonly measured by several themes known as social participation, social cohesion, social network, trust and reciprocity, meanwhile poverty was measured by such livelihood status, poverty line, household income, household welfare and other poverty levels that rely on income and consumption comparison. The findings in this review support the general conclusion that social capital is statistically significant in reducing the poverty of households. More qualitative studies are recommended to be conducted due to several recommendations which are to have specific and a standard systematic review method for guide research synthesis in context social capital with poverty reduction. Other than that complementary searching techniques such as citation tracking, reference searching, snowballing and contacting experts are needed.
4IR and Right to Education in Nigeria: Synergybetween Legal Instruments and Stem Education
Authors: Abdulraheem-Mustapha Mariam Adepeju 
Published: April 2021

Laws and policies have important roles to play in advancing the Fourth Industrial Revolution (4IR) through Science, Technology, Engineering and Mathematics (STEM) research in Nigeria. STEM education and knowledge brings about development by converging scholars across the world with recent research discoveries. In order for Nigeria to reap the maximum benefits from the 4IR, its legal system must come in line with the principles advanced by the 4IR. It is important to state that the laws which have been enacted before the contemporary era are inadequate and obsolete.
Education (STEM education inclusive) which will benefit the most from thenewrevolution would demand new legal instrumentsthat are adequate and effective to cater for the legal and policy demands of the 4IR by bringing forth a more current and inclusive legal protection for all the relevant beneficiaries. Using doctrinal methodology, thispaperexamines4IR and right to education in Nigeria with a view to establishing the relationship between the legal instruments and STEM education with the objective of advancing the agenda of the relevance of all fields of education for the next generation.The paper is divided into six sections and the findings show that, education (STEM education inclusive) is bedeviled with many challenges andthe extant laws are inadequate to solve them.Thus, making the goal of 4IR unachievable in Nigeria. To reach the greatest dexterities in all works of life, the paper concludes by bringing the significance of laws and policies that wouldaccommodate free STEM education in secondary and tertiary school levels in order to answer the call for 4IR. It recommends research collaboration across STEM fields for integrated curriculum and an amendment of the Constitution. It also advocates for gender equality and investing more in STEM education for having a transformative shift in Nigeria for the purpose of achieving 4IR.
Social Entrepreneurship: A Bibliometric-Based Research Trend
Authors: Et.al Aliya Yesmin 
Published: April 2021

Social entrepreneurship is a relatively novel topic and popular area of research and practice. It is recognised as a key instrument for addressing social issues and promoting sustainable development.The evolution of the social entrepreneurship concept has been discussed in the entrepreneurship domain last fifteen years.Therefore, a comprehensive inquiry of the overall body of knowledge relating tosocial entrepreneurship research in the entrepreneurship domain is vital for stimulating social entrepreneurship ecosystems. The research aims to support further study based on the current research trend through graphical visualization and bibliographic analysis. This study also maps the expansion of scientific and academic researchto explain the most recent stage in developing the phenomenon. It presents a general structure of the field and details of the main topics studied in this discipline. One thousand seven hundred sixty-three (1763) research papers published in the Scopus database from 1996 to 2019 were reviewed using bibliometric statistics covering 23 years. Thus, the study, therefore, serves to map trends in the development of the research in this field. The results showed some useful insights, such as the pattern of annual publications, top citation-based authors, organizations, nations, and publishers worldwide. This paper will also provide a primary reference source for the researcher to establish a theoretical framework in this area.
Identification of Potency for Developing Business Value of Negeri Katon Tourism Village, District of Pesawaran, Lampung Province
Authors: Et.al Agus Purnomo 
Published: April 2021

Development of a tourism villageis inseparable from the development and excavation of the tourism potentials itself. The issue that should be a concern in the development of tourism village is how the community can be encouraged and developed continuously, so that the potential of the village and society can be developed optimally (Adityaji, 2018). Negeri Katon is one of the tourist villages in the district of Pesawaran, Lampung province with the potential such as handicraft tourism, namely Tapis. The problem is the lack of knowledge and individual ability of the community in managing the business, as well as a lack of creativity and innovation in production and marketing. This research aims to identify the potential value of business of Negeri Katon Tourism Village, district of Pesawaran, Lampung province.
Methods of research using qualitative methods with observation data collection techniques, interviews, and documentation. Data analysis techniques use descriptive techniques. The results of this research show that there is a large potential of Negeri Katon Tourism Village to be developed so that it has good business value. Negeri Katon Tourism Village has carried out various activities to improve the tourism value, both in the form of independent activities and cooperation with the Government and private sector. It is hoped that this research can be useful in drafting a strategy to increase business and tourism value for the community, especially for the local government of Lampung province.
Do Share Repurchases Promote Efficient Stock Price?
Authors: Et.al Chong-Meng Chee 
Published: April 2021

Purpose: This paper examines whether a greater firm’s repurchase intensity translates into more efficient stock price.
Design/ Methodology/ Approach: An unbalanced panel data, that consists of a sample of 337 US repurchasing firms between 2012 and 2016, was analyzed. Based on the result of the Hausman test, fixed effects estimator was employed to estimate the coefficients. To address heterogeneity across time and firms, time effect and standard error clustered by firms were applied.
Findings:Agreater firms’ share buyback intensity stimulates faster incorporation of information in price and results more efficient stock prices. The main findings were further confirmed with robustness test and supports the notion that share repurchase serves as signalling tool and price support to promote more efficient stock price.
Practical implication: The finding has implication on how share repurchase can be used in three ways: to ease panic selling and deep selling pressure during the downtime; enhance informed trading in which is a result of information signalled by managerial share repurchases; and attract investors’ attention on neglected and undervalued stock.
Originality/value: This research provides new insight and empirical evidenceto reject public cynicism about share repurchases used by firms to manipulate their share prices.
Door Detection Based on Geometrical Features and Harris Corner
Authors: Et.al Md. Akber Hossain 
Published: April 2021

Door is a very significant element as it enables a person to enter a house or room. Though identifying doorway is an easy task for a regular person, for robots or visually impaired people it is a challenging task. To overcome this challenge, we have proposed a door detection method. Our proposed method is based on Prewitt edge detection method and Harris corner detector. Here, we are using a number of predefined rules to detect the doorframe correctly. To establish the robustness of our proposed method, we have formed a substantial dataset of scene images that are captured in various unfamiliar environments. Our experimental results validate that our proposed method is robust against changes in viewpoint, shapes, occlusions, illumination, colors, sizes, orientations, and textures of the door. The experimental results show that our proposed method reaches 87.45% accuracy as well as achieves lower false positive rate and lower computational time.
Education in the time of covid-19 lockdown - Academics the next level of covid warriors
Authors: Et.al Dr. Nancy Prasanna Joseph 
Published: April 2021

The worldwide COVID-19 pandemic is influencing individuals' work-life balance over the globe. For scholastics, control approaches established by most nations have inferred an unexpected change to work from home, a progress to internet educating and tutoring, and an alteration of research works. In this paper we talk about in what way the COVID-19 emergency is influencing the work of academics. We contend that scholarly world must cultivate a culture of care, assist us with new focus on what is generally significant, and rethink greatness in educating and examination. Such re-direction can make scholastic practice more conscious and reasonable, presently during control yet in addition once the pandemic has passed. We finish up giving functional proposals on the best way to reestablish our training, which definitely involves re-surveying the social-mental, political, and ecological ramifications of scholastic exercises and our scale of values. Work from home turned into a need because of lockdown requirements. As governments are right now detailing conventions to permit organizations to resume their commercial establishments and reboot the economic juncture, a few colleges and educational institutions are continuing warily and making arrangements to provide teaching distantly toward the beginning of the new academic year. In any case, the pandemic has made it compulsory to work from home and this has demonstrated testing in various manners for the academics. The corona virus has closed down institutional offices, including research centers, libraries and documents, and halted field activities. Libraries are attempting their best to offer computerized assets; however a significant number of these have not been digitized or bought. Be that as it may, reality paints an alternate picture. Academics have needed to figure out how to utilize new innovation rapidly to educate team up, and give understudy oversight. They have needed to locate a tranquil space in their homes - which is more diligently when the family unit remembers small children for need of recreation or self-teaching - to keep arranging and writing papers. Education organizations may be helpful, however they despite everything have a few desires for productiveness.