bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosocial characteristics pattern correlated with HIV-related risky sexual behavior among HIV-negative men who have sex with men: a latent profile analysis.
Authors: Zhai Mengxi , Duan Zhizhou , Tian Jiawei , Jiang Qingqing , Zhu Biao , Xiao Chenchang , Yu Bin , Yan Hong 
Published: November 2021

Abstract
Background

Men who have sex with men (MSM) have become a high-risky population of HIV infection due to their risk sexual behaviors. The psychosocial characteristics play an important effect on HIV-related risky behaviors. This current study aimed to explore the relationship between HIV-related risky behaviors and the latent pattern of psychosocial characteristics among HIV-negative MSM.
Method

Participants were recruited from Wuhan, Nanchang, and Changsha city from September 2017 to January 2018. The basic socio-demographic characteristics, psychosocial characteristics and HIV-related risky behaviors were collected by self-administered questionnaire and standardize scales. Latent profile analysis (LPA) was used to create the latent classes using variables associated with HIV-related risky behaviors, including social support, reliance, sexual minority stigma, identity concealment, adverse childhood experience and depression.
Results

Three psychosocial characteristic patterns were revealed by the LPA. “identity concealment group” (IC group) and “ACE group” represented the highest risk profile with highest score of identity concealment and adverse childhood experience (ACE), respectively. “IC group” have a higher likelihood of one-night male partners (AOR=2.74, 95%CI=1.54, 4.90), both fixed and one-night male partners (AOR=2.01, 95%CI=1.34-3.01) and HIV-unsure male partner (AOR=2.12, 95%CI=1.44-3.13) compared with “social support and resilience group” (SR group). ACE group were more likely having inconsistent condom use (AOR=2.58, 95%CI=1.41-4.73), and having sex with HIV-positive male partner (AOR=4.90, 95%CI=1.95-12.30) with comparison of SR group. Interesting, ACE group had a higher ratio (90.0%) of inconsistent condom use among MSM whose male partners were HIV-positive.
Conclusions

Six important psychosocial factors were divided into three latent pattern classes. Compared with “social support and reliance group”, “identity concealment group” and “ACE group” were more likely to engage in HIV-related risky sexual behaviors. Besides mental health guidance, promoting serological disclosure of sexual partners and consistent condom use behavior is critical for MSM with higher level of identity concealment or ACE.
Analysis and Prognosis of Tumor Immune Infiltrates and Immune Microenvironment of m6A-Related LncRNAs in Patients with Gastric Cancer
Authors: Huang Jiarong , Song Jinxuan , Li Xiangyu , Liu Shuangfei , Huang Wentao , Shen Ziyi , Cheng Yan , Kou Shien , Gao Zhenguo , Tian Yunhong , Hu Jiani 
Published: November 2021

Abstract
Background

Studies have shown that long noncoding RNAs and N6-methyladenosine play an important role in gastric cancer. The purpose of this study was to determine the correlation and prognostic value of m6A-related lncRNAs and immune infiltration in gastric cancer.
Methods

We downloaded the clinically related information and RNA-Seq transcriptome data of gastric cancer patients from the TCGA database. Univariate Cox regression analysis and Pearson analysis were used to screen out m6A-related lncRNAs. Consensus cluster analysis was used to divide the sample into two clusters, and LASSO analysis and minimum absolute shrinkage were used to construct a risk scoring model.
Results

A total of 25 lncRNA expression profiles were screened, and gastric cancer patients were divided into different subtypes. Cluster 2 had a better prognosis, but its matrix score, estimate score and immune score were low. Cluster 1 was rich in resting memory CD4 T cells, regulatory T cells, monocytes, and resting mast cells, and Cluster 2 was rich in activated memory CD4 T cells and follicular helper T cells. Thirteen lncRNAs were selected to construct a risk model, and the prognosis of gastric cancer patients in the high-risk group was poor. The expression of PD-L1 in tumors is significantly higher than that in normal tissues. Univariate and multivariate Cox regression analysis results showed that the overall survival rate was significantly related to stage and risk score, which can be used as an independent prognostic factor. The results of the heat map and scatter plot showed that clusters (P=0.0045) and grade (G1-2, G3, P=0.0037) were significantly related to prognosis. The results of the relationship between the risk score and immune cell infiltration showed that memory B cells, resting dendritic cells, M0 macrophages, and M2 macrophages were positively correlated with risk scores, while resting mast cells, monocytes, activated NK cells, and follicular helper T cells were negatively correlated with risk scores.
Conclusion

The results of this study indicate that m6A-related lncRNAs may play an important role in the prognosis of gastric cancer patients and the tumor immune microenvironment and provide help for the treatment of gastric cancer patients.
Effect of Ultrasound-guided Lung Recruitment Maneuvers on Atelectasis in Lung-healthy Patients Undergoing Laparoscopic Gynecologic Surgery: a Randomized Controlled Trial
Authors: Liu Yi , Wang Jingyu , Wan Yong , Geng Yuan , Zhang Yiran , Su Hang , Yang Yujiao 
Published: November 2021

Abstract
BackgroundAtelectasis is a major cause of hypoxemia during general anesthesia and postoperative pulmonary complications (PPCs).Some previous reported that the combined use of lung recruitment procedures (LRMs) and positive end-expiratory pressure (PEEP) in mechanical ventilation mode contributes to the avoidance of PPCs in patients after general anesthesia, while others suggest that the use of LRMs makes patients more susceptible to hemodynamic disturbances and lung injury, and is of limited potential to decrease the incidence of PPCs. From this perspective, controversy exists as to whether LRMs should be routinely applied to surgical patients. More importantly, corresponding clinical studies are also lacking. Therefore, this trial was conducted with the aim of solving the above problem.MethodsIn current clinical trial, patients undergoing laparoscopic gynecologic surgery with healthy lungs were randomized to the recruitment maneuvers group (RM group; 6 cm H2O PEEP and RMs) and the control group (C group; 6 cm H2O PEEP and no RMs). Lung ultrasound was performed on patients at five separate time points. During mechanical ventilation, patients in the RM group received ultrasound-guided pulmonary resuscitation when atelectasis was detected, while the C group did not intervene. Lung ultrasound scores were used to evaluate the incidence and severity of atelectasis.ResultsAfter LRMs, the incidence of atelectasis was significantly lower in the RM group (40%) than in the C group (80%) 15 minutes after arrival in the post-anesthesia care unit (PACU), and this difference did not persist for 24 hours after surgery. Meanwhile, postoperative pulmonary complications showed no difference between the two groups.ConclusionsThe combination of LRMs and PEEP decreased the incidence of atelectasis 15 minutes after admission to the PACU, but did not improve PPCs in adults with healthy lungs. Hence, for lung-healthy patients undergoing gynecological laparoscopic surgery, we do not recommend routine recruitment maneuvers. Trial registration (prospectively registered)ChiCTR2000033529. Registered on June 4, 2020.
Angiotensin Receptor Type 1 Inhibition in Lymphopenia and in Neutropenia After Traumatic Brain Injury In Mice: a Randomized Controlled Study (ATLANTIS)
Authors: Timaru-Kast Ralph , Coronel-Castello Shila P. , Krämer Tobias , Hugonnet André V. , Schäfer Michael K.E. , Sebastiani Anne , Thal Serge C. 
Published: November 2021

Abstract
Background: Cerebral inflammation with invasion of neutrophils and lymphocytes is an important factor in the process of secondary brain damage expansion after traumatic brain injury (TBI). Depletion of neutrophils in mice has been shown to reduce neurologic impairment after TBI. The intrinsic cerebral renin-angiotensin system is an important mediator of cerebral inflammation, as inhibition of the angiotensin II receptor type 1 (AT1) with candesartan improves neurologic recovery, and reduces secondary brain damage and cerebral neutrophil invasion after TBI. The present study was therefore designed to determine the role of immune cells in AT1 inhibition-mediated neuroprotection after TBI. Methods: In study A we assessed the effect of neutrophil depletion in mice after TBI. In study B we investigated the impact of RAG1 deficiency (RAG1-/-; mice without mature B- and T-lymphocytes) after TBI. In study C we investigated the role of neutrophils in candesartan mediated protection after TBI in wild-type mice with and without neutrophil depletion. In study D we examined the role of lymphocytes in AT1 inhibition mediated neuroprotection after TBI in RAG1-/-.Results: Neutropenic and RAG1-/- mice showed reduced brain damage compared to control groups. In control antibody treated wild type mice AT1 inhibition reduced lesion volumes and inflammation compared to vehicle, while in neutropenic mice, candesartan had no effect. In RAG1-/- mice AT1 inhibition resulted in reduction of brain damage and neuroinflammation compared to vehicle group. Conclusion: The present results demonstrate, that reduction of neutrophils and of lymphocytes as well as AT1 inhibition in wild type and RAG1-/- mice reduce brain damage and inflammation after TBI. However, AT1 inhibition was neuroprotective in RAG1-/- mice, but not in neutropenic mice. Therefore, the results indicate that AT1 inhibition mediated neuroprotection may be exerted by anti-inflammatory effects on neutrophils, with a subsequent reduction of neutrophil invasion.
Fully coupled hydrological–hydrodynamic modeling of a basin–river–lake transboundary system in Southern South America
Authors: Possa Thais Magalhães , Collares Gilberto Loguercio , Boeira Lukas dos Santos , Jardim Pedro Frediani , Fan Fernando Mainardi , Terra Viviane Santos Silva 
Published: November 2021

Abstract
The Mirim and Patos Lagoons form the largest lagoon complex in South America. Wind is one of the dominant climatic elements of circulation and water levels in the basin. Therefore, we aimed to better understand the effects of wind on the Mirim–São Gonçalo watershed by applying the MGB hydrological model and to assess whether it would produce satisfactory results for modeling. Various tests were performed to determine the best representation of the processes involved and the observed levels. The best results were obtained with the inclusion of sub-daily wind data in the simulation and also the downstream boundary condition by using the observed water level data at the sluice dam of the São Gonçalo channel. The results showed that the model could successfully simulate the levels and demonstrated the importance of including the wind when modeling the hydrodynamic processes of large lake environments.
PERFIL EPIDEMIOLÓGICO DO CARCINOMA DE CÉLULAS ESCAMOSAS DE CAVIDADE ORAL E OROFARINGE DIAGNOSTICADOS NA LIGA MOSSOROENSE DE ESTUDOS E COMBATE AO CÂNCER
Authors: Ribeiro de Paula Mariana , Ieracitano Vieira Leonardo , Pereira de Lira Marcelo , Moreira Freire Geison , De Moraes Maiara 
Published: November 2021

RESUMO
Introdução: O carcinoma de células escamosas (CCE) de cavidade oral e orofaringe é uma neoplasia epitelial maligna comum, respondendo por 90 a 95% dos tumores de cabeça e pescoço encontrados no Brasil e no Reino Unido, sendo que, em 2020, houveram 3300 novos casos de tumor de boca na região Nordeste e 300 no Rio Grande do Norte. Ele está ligado a hábitos comportamentais, como tabagismo e etilismo de longa data e à infecção por Papilomavírus humano (HPV), além de apresentar considerável mortalidade. Objetivos: Esse estudo objetivou descrever o perfil epidemiológico dos pacientes diagnosticados com essa neoplasia no período entre 2006 a 2018 na Liga Mossoroense de Estudos e Combate ao Câncer (LMECC), Mossoró, RN. Metodologia: Foi realizado um estudo epidemiológico do tipo observacional com delineamento transversal a partir de dados presentes nos prontuários clínicos e laudos anatomopatológicos pertencentes à LMECC e no Sistema de Informações sobre Mortalidade. Os dados foram analisados a partir do Software R, utilizando o teste de Wilcoxon-Mann-Whitney para as análises inferenciais e o método de Kaplan-Meier para análise da sobrevida. Resultados: Durante o estudo, foram analisados 353 prontuários, sendo 128 excluídos. Do total de prontuários analisados, 70,22% eram de homens, 65,33% com idade entre 46-70 anos e com predomínio da cor branca (51,57%). Destes, 25,78% eram tabagistas e 39,11% tabagistas e etilistas. O principal tratamento identificado foi a associação de cirurgia, quimioterapia e radioterapia. Observou-se 49,10% óbitos em decorrência deste tipo de câncer. O principal estádio patológico encontrado foi o IVA (34,22%). Apresentaram maior sobrevida em 60 meses, os pacientes com mais de 70 anos ao diagnóstico, aqueles cujo tratamento foi exclusivamente cirúrgico e, ao considerar os hábitos comportamentais, notou-se menor sobrevida em 60 meses daqueles indivíduos que tinham hábito de etilismo e tabagismo. Conclusões: Nossos resultados sugerem que a grande quantidade de óbitos encontrados decorreu do CCE e que os hábitos comportamentais provavelmente influenciaram esse desfecho clínico. Ademais, destaca a importância do diagnóstico precoce a fim de reduzir óbitos e melhorar a qualidade de vida dos indivíduos acometidos e a necessidade de implementação de campanhas educativas que informem a população sobre os principais fatores de risco associados ao desenvolvimento dessa neoplasia.

Palavras-Chave: Carcinoma de Células Escamosas de Cabeça e Pescoço; Carcinoma de Células Escamosas; Neoplasias Bucais; Neoplasias Orofaríngeas; Epidemiologia
O SORRISO GENGIVAL E O RESGATE DA AUTO-ESTIMA MEDIANTE A ODONTOLOGIA ESTÉTICA: REVISÃO INTEGRATIVA
Authors: Vieira de Sousa Glenda , Ferreira de Souza Maria Eduarda , Rebeca Santos Nascimento Yasmin , Costa de Araújo Souza Georgia , Bittencourt Dutra dos Santos Patrícia , Tôrres Ana Clara Soares Paiva 
Published: November 2021

Introdução: O sorriso gengival tem mostrado ser um fator de desconforto estético e psicológico, além de afetar as relações interpessoais e a autoestima dos pacientes. Diante disso, procedimentos estéticos têm sido desenvolvidos com o intuito de melhorar a qualidade de vida de quem os procuram. Objetivo: Analisar qual o impacto que os procedimentos odontológicos estéticos possuem na recuperação da autoestima e satisfação dos pacientes com sorriso gengival. Metodologia: A temática é abordada por meio da revisão integrativa da literatura. Para a seleção dos artigos utilizou-se as bases de dados: MEDLINE, LILACS, SciELO BBO e PubMed, publicações escritas em inglês, português ou espanhol, no período de 2010 a 2020. A amostra desta revisão constituiu-se de 06 artigos. Resultados: Foi observado que o sorriso gengival causa desconforto estético e psicológico ao indivíduo. As prevalências das etiologias relacionadas foram erupção passiva ou tardia dos dentes, extrusão dentoalveolar anterior, excesso maxilar e lábio superior curto. Os procedimentos mais utilizados foram a aplicação de toxina botulínica, a qual mostrou-se ser promissora para a correção do sorriso gengival assim como o reposicionamento labial. Conclusões: Os estudos mostraram que os procedimentos odontológicos estéticos para correção do sorriso gengival contribuem para satisfação do paciente e melhora da autoestima e as técnicas menos invasivas e com melhor pós-operatório apontadas, são a aplicação da toxina botulínica e o reposicionamento labial.
Recent Advances in Gelatin-Based Nanomedicine for Targeted Delivery of Anti-Cancer Drugs
Authors: Raza Faisal , Siyu Liu , Zafar Hajra , Kamal Zul , Zheng Bo , Su Jing , Qiu Mingfeng 
Published: November 2021

:
Nanoparticles based on natural polymers are utilized for the development of a wide range of drug delivery
systems (DDS) in the current era. Gelatin-based nanoparticles, for example, are a remarkable cancer therapy
with high efficacy and specificity. This paper reviews the recent advancements in gelatin-based
nanomedicine for use in cancer therapeutics. Due to the characteristics features of gelatin, such as biocompatibility,
biodegradability, stability, and good surface properties, these nanoparticles provide high therapeutic potency
in cancer nanomedicine. The surface of gelatin can be modified in a number of ways using various ligands
to explore the platform for the development of a more novel DDS. Various methods are available for the
preparation of gelatin nanomedicine discussed in this review. In addition, various cross-linkers to stabilized
nanocarriers and stimuli base gelatin nanoparticles are reviewed. Furthermore, recent advances and research in
gelatin-based nanomedicine are discussed. Also, some drawbacks and challenges are evaluated. In general, this
paper paves the pathway to identify the details about the gelatin-based DDS for cancer therapy.
Lipids as Early and Minimally Invasive Biomarkers for Alzheimer’s
Disease
Authors: Cháfer-Pericás Consuelo , Casas-Fernández Esther , Peña-Bautista Carmen , Baquero Miguel 
Published: November 2021

:
Alzheimer’s disease (AD) is the most common neurodegenerative disorder worldwide.
Specifically, typical late-onset AD is a sporadic form with a complex etiology that affects over 90%
of patients. The current gold standard for AD diagnosis is based on the determination of amyloid
status by analyzing cerebrospinal fluid samples or brain positron emission tomography. These procedures
can be used widely as they have several disadvantages (expensive, invasive). As an alternative,
blood metabolites have recently emerged as promising AD biomarkers. Small molecules that
cross the compromised AD blood-brain barrier could be determined in plasma to improve clinical
AD diagnosis at early stages through minimally invasive techniques. Specifically, lipids could play
an important role in AD since the brain has a high lipid content, and they are present ubiquitously
inside amyloid plaques. Therefore, a systematic review was performed with the aim of identifying
blood lipid metabolites as potential early AD biomarkers. In conclusion, some lipid families (fatty
acids, glycerolipids, glycerophospholipids, sphingolipids, lipid peroxidation compounds) have
shown impaired levels at early AD stages. Ceramide levels were significantly higher in AD subjects,
and polyunsaturated fatty acids levels were significantly lower in AD. Also, high arachidonic acid
levels were found in AD patients in contrast to low sphingomyelin levels. Consequently, these lipid
biomarkers could be used for minimally invasive and early AD clinical diagnosis.
Congenital Malaria in Newborns Delivered to Malaria-infected Mothers in the Hilly Region of Northern India: Is it Deadly?
Authors: Singh Avinish , Mohan Kriti , Omar Balram Ji , Chacham Swathi , Chaturvedi Jaya , Basu Sriparna , Bhakat Rahul 
Published: November 2021

Background:
Malaria is endemic in many states of India. Though there are reports of
maternal and congenital malaria from endemic areas, however, there remains a paucity of data
from hilly terrains. The present study evaluated the prevalence, clinical and microbiological spectrum
of maternal and congenital malaria at a tertiary health care facility in Northern India over a period
of 18 months.

Methods:
In this observational study, mothers along with their newborns were evaluated for
malaria by maternal, placental, and cord blood smear examination and rapid point-of-care diagnostic
serological tests. Positive cases were confirmed by polymerase chain reaction. Mother-newborn
duos were followed up till discharge from the hospital.

Results:
A total of 843 mothers delivered during the study period and were screened along with
their newborns and placentae. A total of Ten (1.18%) mothers had evidence of malarial parasitemia
(Plasmodium vivax, n=7 and Pl. falciparum, n=3), however, none of the placental and cord blood
samples were positive for malaria. Overall, 127 (15.1%) neonates required admission in neonatal intensive
care unit for various morbidities. Incidence of small for gestational age (SGA) was high
(n=210; 24.9%). Multivariate logistic regression analysis demonstrated maternal malaria to be an
independent contributor for SGA [Odds Ratio (95% Confidence Interval), 10.7 (2.06 - 49.72)].
However, only 2% variance of SGA could be explained by maternal malaria alone.

Conclusions:
We report an encouragingly lower incidence of maternal malaria in mothers attending
for delivery and a ‘Zero’ incidence for placental and congenital malaria during the study period as
compared to national data (upto 7.4% in non-immune mothers), although maternal malaria could
be a causative factor for SGA.
Synthesis, Characterization and Biochemical Analysis of Azo-metal complex
of Embelin with Second Group Transition Metals
Authors: Mir Mohd Amin , Ashraf Muhammad Waqar 
Published: November 2021

Aim:
The objective of the work is to synthesize, characterize and biochemically analyze
Azo-metal complex of Embelin with Second Group Transition Metals.

Background:
The genus Embelia is a well-known herb and has considerable importance in the
field of pharmaceutical chemistry. The plant species has been used considerably as a traditional
medicine in Ayurveda, old Chinese medicine, and Siddha for a long time. The dried berries of this
plant, called “vidanga” have boundless biochemical properties, like anthelmintic, carminative,
antibacterial, antibiotic, and hypoglycemic.

Objective:
Embelin, metal-embelin (EM) and azo-metal-embelin (EAM) complexes were synthesized,
analysed for antioxidant and antimicrobial properties.

Method:
The metal-embelin (EM) complexes and metal-azo-embelin (EAM) complexes were synthesized
by pure mixing of embelin, azo-embelin and metals viz, Tc, Ru, Rh, Pd, Ag and Cd. The
embelin and EAN complexes were analysed by various spectroscopic techniques, viz, UV-visible,
FTIR, NMR, TGA, MS and CHNS analysis.

Results:
The results authenticate the reaction between metals, and bidentate embelin occurs via quinonic
and enolic oxygen atoms as [M (Emb) 2 (H2O)] 2H2O and [M (Emb-Azo)2 (H2O)2]. The antioxidant
results show that the complexation between metals and compounds decreases the antioxidant
potential significantly. In contrast, the antimicrobial activity shows that cobalt and nickel embelin
complexes showed more than 74% growth inhibition against the concerned microbes in comparison
to embelin alone.

Conclusion:
As the results are taken into consideration, the scavenging property of embelin shows
the reduction in power upon complexation with metals and azo-metals. Also, embelin and its associates
as metal-embelin and metal-azo-embelin can be used as antioxidant and antimicrobial agents
significantly.