bluuebunny/crossref_metadata_2025_split huggingface dataset:
CSF in Epileptic Prodromal Alzheimer's Disease: No Diagnostic Contribution but a Pathophysiological One
Authors: Cretin Benjamin , Bousiges Olivier , Hautecloque Geoffroy , Philippi Nathalie , Blanc Frederic , Dibitonto Laure , Martin-Hunyadi Catherine , Sellal François 
Published: August 2021

Objective: To study whether cerebrospinal fluid (CSF) analysis may serve as a diagnostic test for the screening of epilepsy in sporadic prodromal Alzheimer's disease (AD).Methods: A total of 29 patients with epileptic prodromal sporadic AD patients (epADs) were included and were retrospectively compared with 38 non-epileptic prodromal AD patients (nepADs) for demographics, clinical features, Mini-Mental Status Examination (MMSE) results, CSF biomarkers, and electro-radiological features.Results: Our study did not show any significant differences in CSF biomarkers regarding neurodegeneration, albumin levels, and inflammation between epADs and nepADs. The epADs were significantly older at diagnosis (p = 0.001), more hypertensive (p = 0.01), and displayed larger white matter hyperintensities on brain magnetic resonance imaging (MRI; p = 0.05). There was a significant correlation between the CSF Aβ-42 and Aβ-40 levels with interictal epileptiform discharges and delta slowing on EEGs recordings, respectively (p = 0.03).Conclusions: Our study suggests that CSF may not serve as a surrogate marker of epilepsy in prodromal AD and cannot circumvent the operator-dependent and time-consuming interpretation of EEG recordings. In humans, AD-related epileptogenesis appears to involve the Aβ peptides but likely also additional non-amyloid factors such as small-vessel disease (i.e., white matter hyperintensities).
Case Report: Short-Term Spinal Cord Stimulation and Peripheral Nerve Stimulation for the Treatment of Trigeminal Postherpetic Neuralgia in Elderly Patients
Authors: Zhao Lin , Song Tao 
Published: August 2021

Objective: We aimed to report on the use of short-term high cervical spinal cord stimulation (SCS) combined with peripheral nerve stimulation (PNS) to successfully treat trigeminal postherpetic neuralgia (TPHN) affecting the V2 and V3 divisions. We also sought to use a novel PNS approach to the maxillary nerve next to the external opening of the foramen rotundum (FR) to treat TPHN at the V2 division.Method: Two elderly patients successfully treated with different neuromodulation methods for TPHN are presented in this case series.Results: The first case referred to an 83-year-old Chinese female patient with V2 and V3 TPHN who experienced a significant pain relief using a combination of short-term high cervical SCS at the C1–C2 level and PNS on the infraorbital nerve (ION). Case 2 was a 68-year-old Chinese male patient with V1 and V2 TPHN that obtained an excellent pain relief after having received short-term PNS on the supraorbital nerve (SON), the supratrochlear nerve (STN), and the maxillary nerve. Both reported improvements in their quality of life and ability to perform daily tasks during a 3-month follow-up period.Conclusions: Short-term high cervical SCS at the C1–C2 spinal segments may be a feasible method to treat recent-onset V3 TPHN in elderly patients. Additionally, by placing the stimulation lead next to the external FR opening, we demonstrated a novel PNS approach to the maxillary nerve not previously reported for TPHN therapy.
Intrapleural Administration With Rh-Endostatin and Chemical Irritants in the Control of Malignant Pleural Effusion: A Systematic Review and Meta-Analysis
Authors: Wang Cheng-Qiong , Huang Xiao-Rong , He Min , Zheng Xiao-Tian , Jiang Hong , Chen Qian , Fan Teng-Yan , Zhan Lin , Ling Juan , Feng Ji-Hong , Xiao Xue , Chen Xiao-Fan , Xiao Zheng 
Published: August 2021

IntroductionA modified and recombinant human endostatin (Rh-endostatin) is often used in the control of malignant pleural effusion (MPE) through intrapleural infusion.ObjectivesTo demonstrate the clinical response, survival, and safety of Rh-endostatin plus chemical irritants, their optimal combinations, treatment threshold, and optimal usage, we performed a new systematic review and meta-analysis.MethodologyAll randomized controlled trials (RCTs) were collected from Chinese and English electronic databases (from inception until August 2020). We pooled the data using a series of meta-analyses and summarized the evidence quality following the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.ResultsWe included 75 RCTs recruiting 4,678 patients, which reported six combinations for Rh-endostatin plus chemical irritants. Among the six combinations, only Rh-endostatin plus cisplatin (DDP) with enough trials might improve the complete response [2.29 (1.93, 2.71)] and quality of life [3.01 (2.49, 3.63)] and reduce treatment failure [0.29 (0.25, 0.33)] and progressive disease [0.27 (0.22, 0.34)]. It might not increase the risk of adverse drug reactions. For patients with lung cancer, moderate to massive effusion, initial treatment, Karnofsky Performance Status (KPS) score ≥60, or anticipated survival time ≥3 months, Rh-endostatin (30–45 mg each time, once or twice a week 3–4 times) plus DDP (30–60 mg/m2) obtained a significant improvement in clinical response and a reduction of failure and progressive disease. Most results had good robustness and moderate quality.ConclusionsCurrent evidence suggests that Rh-endostatin with DDP may be an optimal combination, which may improve clinical response and reduce failure and progressive disease with good safety. Rh-endostatin (30–40 mg each time, once or twice a week 3–4 times) with DDP (30–40 mg/m2) may be an optimal usage for achieving an ideal response.
Effects of Educative Materials on Doctors' Intention to Initiate Life-Saving Procedures After a Suicide Attempt: Randomised Controlled Trial
Authors: Braun Marlies , Niederkrotenthaler Thomas 
Published: August 2021

Introduction:The topic of euthanasia, assisted dying, and how to deal with death wishes has received strong public and media attention in many countries. Nevertheless, there is currently no research which has analysed if educative materials that favour or disfavour the initiation of life-saving measures after a suicide attempt impact on attitudes to initiate such procedures among physicians.Materials and Methods:A double-blind randomised controlled trial was conducted to test if educative materials that either support life-saving measures or rather recommend against it after a near-fatal suicide attempt has an effect on intentions to initiate such measures (trial registration: DRKS00024953,www.drks.de).N= 192 doctors from the Medical University Vienna (Austria) participated in the study and either read educative materials not recommending (n= 59), or recommending life-saving measures (n= 64), or were not reading educative materials (n= 69, control group). The primary outcome was intentions to initiate life-saving measures in an open case vignette featuring the case of a terminally ill cancer patient. Other variables assessed were demographics, experiences with terminally ill and dying patients, training or qualification in mental health, specialty, position, whether doctors worked in emergency medicine, and attitudes toward assisted dying. A logistic regression analysis was used.Results:There was no immediate effect of educative materials on intentions to initiate life-saving measures, χ2(2) = 0.94,p= 0.63. The adjusted model including all tested predictors was significant [χ2(15) = 37.82,df= 15,p&lt; 0.001]. Attending position, male gender, low age, and more negative attitudes to assisted dying predicted a decision for life-saving measures. Higher agreement with life-saving measures was reported for a case vignette about a patient with schizophrenia than for a case vignette about a patient with Huntington's disease.Discussion:Educative materials either favouring or disfavouring the initiation of life-saving measures after a suicide attempt do not appear to immediately influence related decision-making processes. Related intentions appear mainly influenced by personal opinions on the topic and by the specific patient case. Good-quality in-depth discussions regarding end-of-life decisions and to develop well-founded and non-opinionated guidelines are highly warranted.
Mindfulness-Based Cognitive Therapy for Unmedicated Obsessive-Compulsive Disorder: A Randomized Controlled Trial With 6-Month Follow-Up
Authors: Zhang Tianran , Lu Lu , Didonna Fabrizio , Wang Zhen , Zhang Haiyin , Fan Qing 
Published: August 2021

Background: This was the first randomized controlled trial (RCT) designed to compare the efficacy of mindfulness-based cognitive therapy (MBCT) on unmedicated obsessive-compulsive disorder with that of the first-line treatment for OCD (SSRIs) or a placebo, as well as to analyze the treatment acceptability and safety of MBCT.Methods: A total of 123 unmedicated OCD patients with mild to moderate symptoms were randomly assigned into selective serotonin reuptake inhibitors group (SSRIs group), MBCT group or psycho-education group (PE group), respectively. They were intervened for 10 weeks. The Yale–Brown Obsessive-Compulsive Scale (Y-BOCS) grade was the primary outcome, and Hamilton Depression Scale-24 (HAMD-24) and Hamilton Anxiety Scale (HAMA) grades were secondary outcomes to be measured at baseline, mid-intervention, post-intervention and 14, 22, and 34 weeks of follow-up. The Five Facet Mindfulness Questionnaire (FFMQ) and Sheehan Disability Scale (SDS) were used to assess mindfulness and social functions, respectively. In addition, treatment acceptability (dropout rate and frequency of occurrence) and safety [adverse event (AE)] of MBCT were investigated.Results: Significant differences were detected in the treatment responses among SSRIs group, MBCT group and PE group. Notably, treatment responses were significantly better in the former two groups than that of PE group (χ2 = 6.448, p = 0.04), although we did not identify significant differences between SSRIs group and MBCT group (χ2 = 1.220, p = 0.543). Observed until 6 months of follow-up, there were no significant differences in treatment response among three groups. No AE was recorded in MBCT group.Conclusion: MBCT is effective in the treatment of unmedicated OCD with mild to moderate symptoms comparable to that of SSRIs, which contributes to maintain the treatment outcomes at follow-up. Besides, MBCT is safe with a good clinical compliance.
Is There Any Association Between Chronic Periodontitis and Anxiety in Adults? A Systematic Review
Authors: Aragão Walessa Alana Bragança , Souza-Monteiro de Deiweson , Frazão Deborah Ribeiro , Né Yago Gecy de Sousa , Ferreira Railson de Oliveira , Rivera Luis Felipe Sarmiento , Saito Miki Taketomi , Rösing Cassiano Kuchenbecker , Fagundes Nathalia Carolina Fernandes , Maia Lucianne Cople , Lima Rafael Rodrigues 
Published: August 2021

Periodontitis is a multifactorial disease triggered by dysbiotic biofilms, involving the host's immune response, systemic and behavioral factors, including psychosocial conditions. This systematic review aimed to investigate the possible association between periodontitis and anxiety in adults. Searches were performed in PubMed, Scopus, Web of Science, Lilacs, Cochrane, and OpenGrey databases, without language restrictions, considering studies in adults (P-Participants), with (E-Exposure) and without periodontitis (C- Comparison) in an outcome of association with anxiety (O-outcome). Methodological quality assessment was carried out using the Newcastle-Ottawa protocol for case-control and cross-sectional studies, followed by an analysis of the level of evidence using the GRADE tool. Metanalysis was not performed due to several differences in methods applied by authors in primary studies. Eleven observational studies were selected according to the inclusion criteria from the total of 6,380 studies retrieved from databases. Eight studies demonstrated higher anxiety levels in subjects with periodontitis, among which only one study presented a high risk of bias. The GRADE tool revealed a low level of evidence for the anxiety outcome measured by the State-Trait Anxiety Inventory (STAI), both for case-control and cross-sectional studies. However, since anxiety may affect the quality of life of many subjects, it reinforces the need for further studies that evaluate this association for more extended periods.Clinical Trial Registration:PROSPERO-CRD42020190445.
Animal-Assisted Therapy in Middle-Aged and Older Patients With Schizophrenia: A Randomized Controlled Trial
Authors: Chen Tzu-Ting , Hsieh Ton-Lin , Chen Mei-Li , Tseng Wei-Ting , Hung Chi-Fa , Chen Chyi-Rong 
Published: August 2021

Objective: Animal-assisted therapy (AAT) has the potential to improve the symptomology, negative emotions, and level of well-being in older adults, as well as patients with mental illness. However, there remains limited evidence supporting the treatment efficacy of AAT in middle-aged and older adults with schizophrenia. Therefore, this study implemented a randomized controlled trial to assess the efficacy of a 12-week AAT psychological intervention with dogs for middle-aged and older patients with chronic schizophrenia in a clinical setting.Method: Patients, age ≥ 40 years, with chronic schizophrenia were allocated randomly to either the AAT group or control group. Patients in the AAT group received an additional hour -long AAT session every week for 12 weeks. Patients in the control group received the usual treatment plus an hour long non-animal related intervention. All patients were assessed based on primary outcome measures before and after the 12-week intervention, including the Positive and Negative Syndrome Scale (PANSS), Depression Anxiety Stress Scales Assessment (DASS), and Chinese Happiness Inventory (CHI).Results: Patients who received AAT had greater improvements in the PANSS and DASS-stress subscale scores than the control group (p &lt; 0.05). The effect was small (success ratio different, SRD = 0.25) for the PANSS and the DASS-stress subscale (SRD = 0.15). There were no significant differences in the change scores of the CHI between the AAT and control groups (p = 0.461).Conclusions: AAT seemed to be effective in reducing psychiatric symptoms and stress levels of middle-aged and older patients with schizophrenia. AAT could be considered as a useful adjunctive therapy to the usual treatment programs.
Influencing Factors on Health Information to Improve Public Health Literacy in the Official WeChat Account of Guangzhou CDC
Authors: Ma Xiaowei , Lu Jianyun , Liu Weisi 
Published: August 2021

Background: Social media is used as a new channel for health information. In China, the official WeChat account is becoming the most popular platform for health information dissemination, which has created a good opportunity for the Centers for Disease Control and Prevention to facilitate health information online to improve emergency public health literacy.Methods: Data were collected from the Guangzhou CDC i-Health official WeChat account between April 1, 2018 and April 30, 2019. Descriptive analysis was performed for basic information about the followers and posts of the official WeChat account. Multiple logistic regression analysis was used to analyze the association among various factors of posts on engagement of followers of the official WeChat account.Results: Among 187,033 followers, the total numbers of post views, shares, likes, add to favorites, and comments for 213 posts were 1,147,308, 8,4671, and 5,535, respectively. Engagement of followers peaked on the dissemination date and gradually declined. The main post topics were health education posts and original posts. In the multiple logistic regression model, the number of post views was found to be significantly associated with infectious disease posts (AOR: 3.20, 95% CI: 1.16–8.81), original posts (AOR: 10.20, 95% CI: 1.17–89.28), and posts with title-reflected content (AOR: 2.93, 95% CI: 1.16–8.81).Conclusion: Our findings facilitate the government to formulate better strategies and improve the effectiveness of public information dissemination.
Recommendations for the recognition, diagnosis, and management of long COVID: a Delphi study
Authors: Nurek Martine , Rayner Clare , Freyer Anette , Taylor Sharon , Järte Linn , MacDermott Nathalie , Delaney Brendan C 
Published: August 2021

BackgroundIn the absence of research into therapies and care pathways for long COVID, guidance based on ‘emerging experience’ is needed.AimTo provide a rapid expert guide for GPs and long COVID clinical services.Design and settingA Delphi study was conducted with a panel of primary and secondary care doctors.MethodRecommendations were generated relating to the investigation and management of long COVID. These were distributed online to a panel of UK doctors (any specialty) with an interest in, lived experience of, and/or experience treating long COVID. Over two rounds of Delphi testing, panellists indicated their agreement with each recommendation (using a five-point Likert scale) and provided comments. Recommendations eliciting a response of ‘strongly agree’, ‘agree’, or ‘neither agree nor disagree’ from 90% or more of responders were taken as showing consensus.ResultsThirty-three clinicians representing 14 specialties reached consensus on 35 recommendations. Chiefly, GPs should consider long COVID in the presence of a wide range of presenting features (not limited to fatigue and breathlessness) and exclude differential diagnoses where appropriate. Detailed history and examination with baseline investigations should be conducted in primary care. Indications for further investigation and specific therapies (for myocarditis, postural tachycardia syndrome, mast cell disorder) include hypoxia/desaturation, chest pain, palpitations, and histamine-related symptoms. Rehabilitation should be individualised, with careful activity pacing (to avoid relapse) and multidisciplinary support.ConclusionLong COVID clinics should operate as part of an integrated care system, with GPs playing a key role in the multidisciplinary team. Holistic care pathways, investigation of specific complications, management of potential symptom clusters, and tailored rehabilitation are needed.
Perceptions of Marketing & Digital Transformationin Greek Public Higher Education Organizations in the Context of Digital Darwinism
Authors: Makrydakis Nektarios 
Published: August 2021

Objective: Marketing and digital transformation in the public institutions of higher education in Greece, have key role in the context of the digital revolution. The study aimed at investigating the perceptions and views explicitly or implicitly of the management of Greek public universities regarding the need to adopt new practices such as marketing and its digital transformation and to find out the factors that shape perceptions. Research Design & Methods: The study adopted a quantitative method conducting in-depth interviews with rectors and vice-rectors of 10 representative Greek Universities. Findings: Results indicated that administrators believe that marketing and its digital transformation have great impact in attracting students and that the duration of the operating time of a university is directly related to the formation of perceptions about marketing and digital transformation in the context of Digital Darwinism. Implications & Recommendations: Universities will be able to understand the extent of their reaction to the adoption of new applications such as marketing. Contribution & Value Added: The present study is primarily a useful tool for public university administrations in their efforts to adopt marketing practices to understand which areas to focus on in order to effectively implement marketing and its digital transformation. The study also provides them with the tools to easily recognize their degree of maturity in terms of their culture and perceptions towards the application of marketing practices. In addition the study enriches the literature on the management field of higher education institutions. It highlights factors such as the duration of operation, the geographical location and the size of a university compared to administrative practices.
Kepemimpinan Kyai dan Perubahan Konsep Pondok Pesantren Pada Pesantren Taâ€™mirul Islam Surakarta
Authors: Mustaâ€™an Mustaâ€™an , Sari Muhammad Dian Rifai 
Published: August 2021

Penelitian ini bertujuan untuk menemukan, menganalisa serta menelaah secara mendalam kepemimpinan kyai untuk melakukan perubahanÂ pondok pesantrenÂ dengan melihat konsep perubahan pondok pesantren Taâ€™mirul Islam Surakarta. Penelitian ini menggunakan pendekatan penelitian deskriptif kualitatif phenomenology. Pendekatan ini dipilih karena dalam penelitian ini peneliti akan mendiskripsian secara rinci serta mendalam mengenai gambaran kondisi yang sebenarnya terjadi di lapangan. Data kualitatif diperoleh dari hasil wawancara, observasi kelas dan dokumen.Â Sumber dan teknik triangulations digunakan untuk mendapatkan kepercayaan dari data ini. Selanjutnya, Flowchart Model yang diusulkan oleh Miles dan Huberman diterapkan dalam hasil study. Hasil penelitian, maka ditemukan bahwa: (1). Dalam penelitian ini peneliti menemukan konsep kepemimpinan kyai dalam melakukan perubahan di situs pondok pesantren Al-Muayyad dan Taâ€™mirul Islam Surakarta meliputi beberapa hal yaitu; Pembaharuan visi dan misi, perubahan kurikulum, Perubahan Isi/subtansi, perubahan metode pendidikan, perubahan kelembagaan dan perubahan tenaga pengajar/ustadz dan ustadzah. Temuan formal pada penelitian ini adalah Kyai dalam melakukan perubahan pada model pondok pesantren yang meliputi; changing structure (kelembagaan, kurikulum, subtansi), changing technology (perubahan metode pendidikan, sarana dan prasarana), changing people (visi-misi dan tenaga pendidikan).
On-Surface Bottom-Up Construction of COF Nanoshells towards Photocatalytic H
2
Production
Authors: Chen Yao , Yang Dong , Gao Yuchen , Li Runlai , An Ke , Wang Wenjing , Zhao Zhanfeng , Xin Xin , Ren Hanjie , Jiang Zhongyi 
Published: August 2021

The rational design of an outer shell is of great significance to promote the photocatalytic efficiency of core-shell structured photocatalysts. Herein, a covalent organic framework (COF) nanoshell was designed and deposited on the cadmium sulfide (CdS) core surface. A typical COF material, TPPA, featuring exceptional stability, was synthesized through interfacial polymerization using 1, 3, 5-triformylphloroglucinol (TP) and p-phenylenediamine (PA) as monomers. The nanoshell endows the CdS@TPPA nanosphere with ordered channels for unimpeded light-harvesting and fast diffusion of reactants/products and well-defined modular building blocks for spatially charge separation. Moreover, the heterojunction formed between CdS and TPPA can further facilitate the effective charge separation at the interface
via
lower exciton binding energy compared with that of pristine TPPA. By modulating the thickness of TPPA nanoshell, the CdS@TPPA nanosphere photocatalyst with the nanoshell thickness of about

8
±
1

nm

exhibits the highest photocatalytic H
2
evolution of 194.1
μ
mol h
-1
(24.3 mmol g
-1
h
-1
, 8 mg), which is superior to most of the reported COF-based photocatalysts. The framework nanoshell in this work may stimulate the thinking about how to design advanced shell architecture in the core-shell structured photocatalysts to achieve coordinated charge and molecule transport.