bluuebunny/crossref_metadata_2025_split huggingface dataset:
One-loop impact factor for the emission of two gluons
Authors: Canay Marc , Del Duca Vittorio 
Published: June 2021

Abstract
We consider one-loop five-point QCD amplitudes in next-to-multi-Regge kinematics, and evaluate the one-loop impact factor for the emission of two gluons. This is the last ingredient which is necessary to evaluate the gluon-jet impact factor at NNLO accuracy in αs. It is also the first instance in which loop-level QCD amplitudes are evaluated in next-to-multi-Regge kinematics, which requires to apply a different Reggeisation ansatz to each colour-ordered amplitude.
The norm attainment problem for functions of projections
Authors: Böttcher Albrecht , Spitkovsky Ilya M. 
Published: June 2021

AbstractThe paper is concerned with the problem of identifying the norm attaining operators in the von Neumann algebra generated by two orthogonal projections on a Hilbert space. Every skew projection on that Hilbert space is contained in such an algebra and hence the results of the paper also describe functions of skew projections and their adjoints that attain the norm.
An existence result for the fractional Kelvin–Voigt’s model on time-dependent cracked domains
Authors: Caponi Maicol , Sapio Francesco 
Published: June 2021

AbstractWe prove an existence result for the fractional Kelvin–Voigt’s model involving Caputo’s derivative on time-dependent cracked domains. We first show the existence of a solution to a regularized version of this problem. Then, we use a compactness argument to derive that the fractional Kelvin–Voigt’s model admits a solution which satisfies an energy-dissipation inequality. Finally, we prove that when the crack is not moving, the solution is unique.
On the Tight Security of TLS 1.3: Theoretically Sound Cryptographic Parameters for Real-World Deployments
Authors: Diemert Denis , Jager Tibor 
Published: June 2021

AbstractWe consider thetheoretically soundselection of cryptographic parameters, such as the size of algebraic groups or RSA keys, for TLS 1.3 in practice. While prior works gave security proofs for TLS 1.3, their security loss isquadraticin the total number of sessions across all users, which due to the pervasive use of TLS is huge. Therefore, in order to deploy TLS 1.3 in a theoretically sound way, it would be necessary to compensate this loss with unreasonably large parameters that would be infeasible for practical use at large scale. Hence, while these previous works show that in principle the design of TLS 1.3 is secure in an asymptotic sense, they do not yet provide any usefulconcretesecurity guarantees for real-world parameters used in practice. In this work, we provide a new security proof for the cryptographic core of TLS 1.3 in the random oracle model, which reduces the security of TLS 1.3tightly(that is, with constant security loss) to the (multi-user) security of its building blocks. For some building blocks, such as the symmetric record layer encryption scheme, we can then rely on prior work to establish tight security. For others, such as the RSA-PSS digital signature scheme currently used in TLS 1.3, we obtain at least alinearloss in the number of users, independent of the number of sessions, which is much easier to compensate with reasonable parameters. Our work also shows that by replacing the RSA-PSS scheme with a tightly secure scheme (e.g., in a future TLS version), one can obtain the first fully tightly secure TLS protocol. Our results enable a theoretically sound selection of parameters for TLS 1.3, even in large-scale settings with many users and sessions per user.
In silico biomechanical design of the metal frame of transcatheter aortic valves: multi-objective shape and cross-sectional size optimization
Authors: Carbonaro Dario , Gallo Diego , Morbiducci Umberto , Audenino Alberto , Chiastra Claudio 
Published: June 2021

AbstractTranscatheter aortic valve (TAV) implantation has become an established alternative to open-hearth surgical valve replacement. Current research aims to improve the treatment safety and extend the range of eligible patients. In this regard, computational modeling is a valuable tool to address these challenges, supporting the design phase by evaluating and optimizing the mechanical performance of the implanted device. In this study, a computational framework is presented for the shape and cross-sectional size optimization of TAV frames. Finite element analyses of TAV implantation were performed in idealized aortic root models with and without calcifications, implementing a mesh-morphing procedure to parametrize the TAV frame. The pullout force magnitude, peak maximum principal stress within the aortic wall, and contact pressure in the left ventricular outflow tract were defined as objectives of the optimization problem to evaluate the device mechanical performance. Design of experiment coupled with surrogate modeling was used to define an approximate relationship between the objectives and the TAV frame parameters. Surrogate models were interrogated within a fixed design space and multi-objective design optimization was conducted. The investigation of the parameter combinations within the design space allowed the successful identification of optimized TAV frame geometries, suited to either a single or groups of aortic root anatomies. The optimization framework was efficient, resulting in TAV frame designs with improved mechanical performance, ultimately leading to enhanced procedural outcomes and reduced costs associated with the device iterative development cycle.
A phase 1 randomized study compare the pharmacokinetics, safety and immunogenicity of HLX04 to reference bevacizumab sourced from the United States, the European Union, and China in healthy Chinese male volunteers
Authors: Zhu Xiaoxue , Qian Hongjie , Sun Jixuan , Wu Min , Yu Chen , Ding Yanhua , Zhang Xiaodi , Chai Katherine , Li Xiaojiao 
Published: June 2021

Abstract
Purpose
To compare the pharmacokinetic profiles, safety and immunogenicity of proposed bevacizumab biosimilar HLX04 with reference bevacizumab in healthy Chinese males.

Methods
In this double-blind Phase 1 study, healthy volunteers (N = 208) were randomized 1:1:1:1 to a single 3 mg/kg intravenous infusion of HLX04 or reference bevacizumab sourced from the United States (bevacizumab-US), the European Union (bevacizumab-EU) or China (bevacizumab-CN). Co-primary endpoints were area under the serum concentration–time profile (AUC) from time zero extrapolated to infinity (AUC0–inf) and from zero to last quantifiable concentration (AUClast). Secondary endpoint was the maximum serum drug concentration (Cmax). Study participants were monitored for treatment-emergent adverse events (TEAEs) and samples were collected for anti-drug antibody (ADA) testing throughout the study.

Results
Pharmacokinetic parameters were similar across groups. The respective geometric least-squares mean ratios (GLSMR) of AUC0–inf, AUClast and Cmax were: 95.7%, 96.0% and 101.8% for HLX04 versus bevacizumab-US; 94.3%, 94.6% and 100.5% for HLX04 versus bevacizumab-EU; and 90.0%, 90.4% and 98.2% for HLX04 versus bevacizumab-CN. For all test-to-reference comparisons, two-sided 90% confidence intervals of GLSMR for AUC0–inf, AUClast and Cmax fell in the pre-specified bioequivalence range (80–125%). There were no notable differences in the frequency, nature and/or grade of TEAEs. No deaths were reported and no ADAs were detected during the study.

Conclusion
HLX04 had similar safety and pharmacokinetic profiles to reference bevacizumab in healthy Chinese males, supporting the confirmatory Phase 3 study investigating the efficacy and safety equivalence between HLX04 and bevacizumab in patients with metastatic colorectal cancer (NCT03511963).

Clinical trial registration
The study was registered with Clinicaltrials.gov, NCT03483649.
Analysis of an inventory system with emergency ordering option at the time of supply disruption
Authors: Poormoaied Saeed , Demirci Ece Zeliha 
Published: June 2021

AbstractThis paper studies a continuous-review stochastic inventory problem for a firm facing random demand and random supply disruptions. The supplier experiences operational (on) and disrupted (off) periods with exponentially distributed durations. The firm adopts an order-up-to level policy during the on period and additionally can release an emergency order based on the inventory level just before disruption. This inventory policy is described by a continuous-time Markov chain model. We analyze the model for two different lead time scenarios and suggest solution approaches yielding the optimal policy parameters. In a numerical study, we explore the value of exercising such a policy and show that an emergency ordering opportunity at the disruption time brings substantial cost savings in cases with high lost sales cost, long off period, and low percentage of supplier’s availability.
Gabra2 is a genetic modifier of Dravet syndrome in mice
Authors: Hawkins Nicole A. , Nomura Toshihiro , Duarte Samantha , Barse Levi , Williams Robert W. , Homanics Gregg E. , Mulligan Megan K. , Contractor Anis , Kearney Jennifer A. 
Published: June 2021

AbstractPathogenic variants in epilepsy genes result in a spectrum of clinical severity. One source of phenotypic heterogeneity is modifier genes that affect expressivity of a primary pathogenic variant. Mouse epilepsy models also display varying degrees of clinical severity on different genetic backgrounds. Mice with heterozygous deletion of Scn1a (Scn1a+/−) model Dravet syndrome, a severe epilepsy most often caused by SCN1A haploinsufficiency. Scn1a+/− mice recapitulate features of Dravet syndrome, including spontaneous seizures, sudden death, and cognitive/behavioral deficits. Scn1a+/− mice maintained on the 129S6/SvEvTac (129) strain have normal lifespan and no spontaneous seizures. In contrast, admixture with C57BL/6J (B6) results in epilepsy and premature lethality. We previously mapped Dravet Survival Modifier loci (Dsm1-Dsm5) responsible for strain-dependent differences in survival. Gabra2, encoding the GABAA α2 subunit, was nominated as a candidate modifier at Dsm1. Direct measurement of GABAA receptors found lower abundance of α2-containing receptors in hippocampal synapses of B6 mice relative to 129. We also identified a B6-specific single nucleotide deletion within Gabra2 that lowers mRNA and protein by nearly 50%. Repair of this deletion reestablished normal levels of Gabra2 expression. In this study, we used B6 mice with a repaired Gabra2 allele to evaluate Gabra2 as a genetic modifier of severity in Scn1a+/− mice. Gabra2 repair restored transcript and protein expression, increased abundance of α2-containing GABAA receptors in hippocampal synapses, and rescued epilepsy phenotypes of Scn1a+/− mice. These findings validate Gabra2 as a genetic modifier of Dravet syndrome, and support enhancing function of α2-containing GABAA receptors as treatment strategy for Dravet syndrome.
Patients with acute myocarditis and preserved systolic left ventricular function: comparison of global and regional longitudinal strain imaging by echocardiography with quantification of late gadolinium enhancement by CMR
Authors: Meindl Christine , Paulus Michael , Poschenrieder Florian , Zeman Florian , Maier Lars S. , Debl Kurt 
Published: June 2021

Abstract
Background
Conventional transthoracic echocardiography (TTE) does often not accurately reveal pathologies in patients with acute myocarditis and preserved left ventricular ejection fraction (LVEEF). Therefore, we investigated the diagnostic value of two-dimensional (2D) speckle tracking echocardiography compared to late gadolinium enhancement (LGE) by cardiac magnetic resonance (CMR) imaging in patients with acute myocarditis and normal global LVEF.

Methods and results
31 patients (group 1) with the diagnosis of acute myocarditis confirmed by CMR according to the Lake Louise criteria and 20 healthy controls (group 2) were analyzed including global longitudinal strain (GLS) and regional longitudinal strain (RLS) derived by the bull’s eye plot. Although preserved LVEF was present in both groups, GLS was significantly lower in patients with acute myocarditis (group 1: GLS − 19.1 ± 1.8% vs. group 2: GLS − 22.1 ± 1.7%, p < 0.001). Compared to controls, lower RLS values were detected predominantly in the lateral, inferolateral, and inferior segments in patients with acute myocarditis. Additionally RLS values were significantly lower in segments without LGE.

Conclusion
In patients with acute myocarditis and preserved LVEF, a significant reduction of GLS compared to healthy subjects was detected. Further RLS adds important information to the localization and extent of myocardial injury.

Graphic abstract
AAV-mediated expression of NFAT decoy oligonucleotides protects from cardiac hypertrophy and heart failure
Authors: Remes Anca , Wagner Andreas H. , Schmiedel Nesrin , Heckmann Markus , Ruf Theresa , Ding Lin , Jungmann Andreas , Senger Frauke , Katus Hugo A. , Ullrich Nina D. , Frey Norbert , Hecker Markus , Müller Oliver J. 
Published: June 2021

AbstractPrevious studies have underlined the substantial role of nuclear factor of activated T cells (NFAT) in hypertension-induced myocardial hypertrophy ultimately leading to heart failure. Here, we aimed at neutralizing four members of the NFAT family of transcription factors as a therapeutic strategy for myocardial hypertrophy transiting to heart failure through AAV-mediated cardiac expression of a RNA-based decoy oligonucleotide (dON) targeting NFATc1-c4. AAV-mediated dON expression markedly decreased endothelin-1 induced cardiomyocyte hypertrophy in vitro and resulted in efficient expression of these dONs in the heart of adult mice as evidenced by fluorescent in situ hybridization. Cardiomyocyte-specific dON expression both before and after induction of transverse aortic constriction protected mice from development of cardiac hypertrophy, cardiac remodeling, and heart failure. Singular systemic administration of AAVs enabling a cell-specific expression of dONs for selective neutralization of a given transcription factor may thus represent a novel and powerful therapeutic approach.
Intermediate to long-term clinical outcomes and survival analysis of the Salto Mobile Bearing total ankle prothesis
Authors: Stadler C. , Stöbich M. , Ruhs B. , Kaufmann C. , Pisecky L. , Stevoska S. , Gotterbarm T. , Klotz M. C. 
Published: June 2021

Abstract
Introduction
Osteoarthritis of the ankle is a major burden to affected patients. While tibio-talar arthrodesis has been the gold-standard regarding the treatment of osteoarthritis of the ankle joint for many years, at present total ankle arthroplasty (TAA) provides appealing clinical outcomes and is continually gaining popularity.
The aim of this study was to evaluate the intermediate- to long-term clinical outcome including the survival rate of Salto Mobile Bearing TAA (Tonier SA, Saint Ismier, France).

Material and methods
In this retrospective study intermediate- to long-term outcomes measures [Ankle Range of Motion (ROM), American Orthopaedic Foot and Ankle Score (AOFAS score) and survival rate] of 171 consecutive TAA were analysed and compared before and after surgery. Revision was defined as secondary surgery with prothesis component removal, while reoperation was defined as a non-revisional secondary surgery involving the ankle.

Results
At a mean follow-up (FU) period of 7.2 ± 2.7 years (range 2.0 to 14.1 years) there was a significant improvement in ankle ROM (total ROM improved from 25.0° ± 15.0° to 28.7° ± 11.3°, p = 0.015; plantarflexion improved from 18.4° ± 11.7° to 20.6° ± 8.2°, p = 0.044; dorsiflexion improved from 6.6° ± 5.7° to 8.1° ± 4.9°, p = 0.011). AOFAS score increased significantly by 41 ± 15 points after surgery (43.3 ± 11.1 before and 84.3 ± 12.0 after surgery, p < 0.001). Overall survival rate within the FU was 81.3% (95% CI 75.3% to 87.3%) with any secondary surgery, 89.9% (95% CI 84.1% to 93.6%) with revision and 93.6% (95% CI 89.8% to 97.3%) with reoperation as endpoint.

Conclusion
This study endorses the previously reported appealing intermediate- to long-term outcomes of the Salto Mobile Bearing TAA. There was a significant increase in ROM and AOFAS score as well as decent implant survival at final FU.
Two-stage mental health survey of first-line medical staff after ending COVID-19 epidemic assistance and isolation
Authors: Xu Li , You Dingyun , Li Chengyu , Zhang Xiyu , Yang Runxu , Kang Chuanyuan , Wang Nianshi , Jin Yuxiong , Yuan Jing , Li Chao , Wei Yujun , Li Ye , Yang Jianzhong 
Published: June 2021

AbstractFacing with COVID-19 epidemic such a catastrophic health emergency, the mental health status of medical staff deserves attention. We conducted a two-stage of psychological status monitoring after the end of the assistance and 14 days of isolation, further targeted the vulnerable groups in need of intervention. The study is a cross-sectional survey on 1156 Yunnan medical staff aid to Hubei. Used Cluster sampling method to collect data at 2 time points (at the end of returning from Wuhan and the 14th day of isolation), from March 18, 2020 to April 6, 2020. Female and nurse had higher rates of depressive symptoms than male and doctors and other occupations. The proportion of female with mild and above moderate anxiety levels (22.91%, 2.61%) was higher than male (17.35%, 1.03%) (p < 0.05). Female had a better impaired sleep quality (45.06%, 17.49%) more than male (28.57%, 7.94%). Medical staff supported in Wuhan and with junior professional titles reported a higher proportion of sleep quality impairment. At the 14th isolation day stage, the proportion of nurses changed from depression to health (9.15%) and from health to depression (6.1%) better than doctors. The front-line medical staffs had suffered greater psychological pressure in the treatment process of major public health emergency. Researches on the dynamic monitor for the change of psychological status after aiding epidemic areas were still in relatively blank stage. Targeting the vulnerable characteristics of aiding medical staff is significant for effective psychological intervention and sustainable operation of health system.
A questionnaire survey on evaluation for penetration and compliance of the Japanese Guideline on Febrile Neutropenia among hematology-oncology physicians and surgeons
Authors: Akiyama Nobu , Okamura Takuho , Yoshida Minoru , Kimura Shun-ichi , Yano Shingo , Yoshida Isao , Kusaba Hiroyuki , Takahashi Kosuke , Fujita Hiroyuki , Fukushima Keitaro , Iwasaki Hiromichi , Tamura Kazuo , Saeki Toshiaki , Takamatsu Yasushi , Zenda Sadamoto 
Published: June 2021

Abstract
Purpose
The Japanese Society of Medical Oncology published a guideline (GL) on febrile neutropenia (FN) in 2017. The study’s purpose is to reveal how widely GL penetrated among physicians and surgeons providing chemotherapy.

Methods
A questionnaire survey was conducted with SurveyMonkey™ for members of the Japanese Association of Supportive Care in Cancer and relevant academic organizations. Each question had four options (always do, do in more than half of patients, do in less than half, do not at all) and a free description form. Responses were analyzed with statistical text-analytics.

Result
A total of 800 responses were retrieved. Major respondents were experts with more than 10-year experience, physicians 54%, and surgeons 46%. Eighty-seven percent of respondents knew and used GL. Forty-eight percent assessed FN with Multinational Association of Supportive Care in Cancer (MASCC) score “always” or “more than half.” Eighty-one percent chose beta-lactam monotherapy as primary treatment in high-risk patients. Seventy-seven percent did oral antibacterial therapy in low-risk patients ambulatorily. Seventy-eight percent administered primary prophylactic G-CSF (ppG-CSF) in FN frequency ≥ 20% regimen. Fifty-nine percent did ppG-CSF for high-risk patients in FN frequency 10–20% regimen. Ninety-seven percent did not use ppG-CSF in FN frequency < 10% regimen. The medians of complete and complete plus partial compliance rates were 46.4% (range 7.0–92.8) and 77.8% (range 35.4–98.7). The complete compliance rates were less than 30% in seven recommendations, including the MASCC score assessment.

Conclusion
GL is estimated to be widely utilized, but some recommendations were not followed, presumably due to a mismatch with actual clinical practices in Japan.
Prediction of chemical compounds properties using a deep learning model
Authors: Galushka Mykola , Swain Chris , Browne Fiona , Mulvenna Maurice D. , Bond Raymond , Gray Darren 
Published: June 2021

AbstractThe discovery of new medications in a cost-effective manner has become the top priority for many pharmaceutical companies. Despite decades of innovation, many of their processes arguably remain relatively inefficient. One such process is the prediction of biological activity. This paper describes a new deep learning model, capable of conducting a preliminary screening of chemical compounds in-silico. The model has been constructed using a variation autoencoder to generate chemical compound fingerprints, which have been used to create a regression model to predict their LogD property and a classification model to predict binding in selected assays from the ChEMBL dataset. The conducted experiments demonstrate accurate prediction of the properties of chemical compounds only using structural definitions and also provide several opportunities to improve upon this model in the future.
Anpassung an Überschwemmungen in südostasiatischen Megastädten – Was kann der Privatsektor leisten?
Authors: Neise Thomas , Leitold Roxana 
Published: June 2021

ZusammenfassungDie fortschreitende Urbanisierung und erste Auswirkungen des Klimawandels verstärken das Überschwemmungsrisiko in küstennahen südostasiatischen Megastädten. Lokale Industriebetriebe sind insbesondere in ihrer Funktions- und Wettbewerbsfähigkeit betroffen. Gleichzeitig wird in den Debatten zu Klimawandelanpassung und Katastrophenrisikominderung die Beteiligung des Privatsektors an Flutschutzmaßnahmen diskutiert, da die lokalen Behörden in Südostasien das Flutrisiko häufig nicht eigenständig substanziell reduzieren können. Vor diesem Hintergrund wird untersucht, wie Industriebetriebe in Ho Chi Minh City (Vietnam) und Jakarta (Indonesien) auf Überschwemmungen reagieren, welche Anpassungsmaßnahmen sie durchführen und inwiefern ihr Engagement einen Beitrag zur kollektiven Anpassungen leistet. Die Analyse von 63 Tiefeninterviews mit Industriebetrieben und 30 Hintergrundgesprächen mit lokalen Behörden, Wirtschaftsverbänden und Wissenschaftler*innen zeigt, dass insbesondere klein- und mittelständische Betriebe Schwierigkeiten haben, effektive Maßnahmen zu ergreifen. Kollektive Anpassungsmaßnahmen vom Privatsektor und lokalen Behörden sind bislang wenig implementiert. Basierend auf den Ergebnissen werden abschließend politische Handlungsempfehlungen skizziert, wie das Engagement des Privatsektors gestärkt und besser integriert werden kann.