bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of Energy Management System based on ISO 50001 for Energy-Cost Saving and Reduction of CO2-Emission: A review of implementation, benefits, and challenges
Authors: Prasetya B , Wahono D R , Dewantoro A , Anggundari W C , Yopi  
Published: December 2021

Abstract
Increasing demand of energy consumption lead to significant support effort to support the sustainable supply by exploring a new resource, development technology, and strategy of energy-mix. In line with this, the development and implementation of management systems in energy utilization play an important role. Based on several studies the implementation of ISO 50001 has significant to improve the performance of energy management, saving of the energy cost, and reduction of CO2 emission. This paper will be reviewed the state of the art of implementation of this standard, benefits, and challenges based on literature studies from several scientific journals and publications released by international organizations, associations, and government policies. Some selected case studies describing quantitative energy performance affected by the implementation of ISO 50001 at the international level with different sectors and some role models from Indonesia are described. Moreover, the challenges and difficulties facing by the implementation of this standard were also reviewed.
Nitrate in groundwater of the west side Magelang Regency, Central Java, Indonesia
Authors: Erlinawati D , Putra D P E , Titisari A D 
Published: December 2021

Abstract
Nitrate (NO3-) pollution in groundwater is generally caused by chemical fertilizers from the agricultural sector and wastewater from onsite sanitation. Magelang Regency, Central Java, Indonesia, is a large food estate that has 206 km2 paddy fields. In addition, this area is inhabited by 1.3 million people who produce onsite sanitary waste every day. Due to the concentration and intensity of fertilization and sanitary waste, which are quite high, Magelang Regency is susceptible to groundwater pollution by nitrate. This study aims to determine the characteristics of nitrate in the groundwater of the west side Magelang Regency, Central Java, Indonesia. The research was carried out by testing groundwater samples taken from several springs, dug wells, and drilled wells used by society for their daily needs. Groundwater sampling was carried out in the wet season and tested using the ion chromatography method to determine the level of nitrate in groundwater and know the chemical characteristics to analyze dominant ions in groundwater. The results showed that the average nitrate was 3.9 mg/l; the deviation standard was 5.12; minimum nitrate was 0 mg/l; and maximum nitrat was 20.78 mg/l. The origin of nitrate content may come come from feces but still in small quantities. Facies of groundwater are Ca-HCO3 and Na-Cl. It can be concluded that the groundwater of the west side Magelang Regency is not yet polluted by nitrate. However, there is still a possibility in the future, so that necessary to apply for groundwater protection immediately.
Forecasting model of power generated by wind power plants
Authors: Ilyas A M , Suyuti A , Gunadin I C , Said S M 
Published: December 2021

Abstract
The power generated by wind power plants is unstable so forecasting is needed to maintain the power balance in an interconnected system. The purpose of this research is to predict the power generated at the Sidrap and Jeneponto wind power plants. The method used is an optimally pruned extreme learning machine (OPELM). The extreme learning machine (ELM) method is used as a comparison method. The mean absolute percentage error (MAPE) method is used to assess the level of forecasting accuracy. Forecasting power generation with Sidrap wind power plant data using the OPELM method is 0.8970% more accurate than the ELM which is 1.0853%. In general, the OPELM method is more accurate. Forecasting power generation with data from the Jeneponto wind power plant using the OPELM method is 2.4887% more accurate than the ELM method is 2.9984%. These results indicate that linear, sigmoid, and Gaussian activation in the OPELM method can increase accuracy. The OPELM method can be tested in forecasting the power generation at the Sidrap and Jeneponto wind power plants to maintain a power balance in the Sulselbar power grid system.
Biogas efficiency from cow dung waste in strengthening energy security during the covid-19 pandemic through a dynamic modeling system
Authors: Lusiana L , Sasongko N A , Kuntjoro Y D , Fakhruddin M , Widrian A F , Siregar A M , Vidura A 
Published: December 2021

AbstractDuring Covid-19 pandemic, the increase in LPG types was 0.6-2.4 million BOE, while in the household sector it was 2.3-6.9 million BOE, so causes LPG import growth ratio to increase by 4.8%/year (BPPT, 2020). Therefore, it is necessary to make efforts to suppress LPG imports by increasing the supply of EBT in the household sector with biogas production. The research aims to look at the biogas production modeling system from the resulting cow dung waste. The research method that studies the literature is based on modeling data based on data obtained using Powersim 10. The results showed that LPG demand in 2020 is 2.4 million BOE that could be fulfilled by a biogas source from 9539238.75 kg ~ 0.9 metric tons cow dung waste. This cow dung waste is able to produce 381569.55 m3/kg of methane gas which is equivalent to 0.59 metric tons LPG, savings Rp 690 M; 103 million liters gasoline, savings Rp 793 M; 64.8 million liters diesel fuel, savings Rp 333.8 M; 80 million liters kerosene, savings Rp 1 T; 4.53 metric tons wood, savings Rp 4.5 T. This favorable situation must be immediately felt by the community with an estimate of future benefits.
Analysis of Indonesia and New Zealand geothermal regulation
Authors: Bramantio B , Sumantri S H , Thamrin S , Sasongko N A 
Published: December 2021

Abstract
Regulation is the important things as the framework and reference for developer to conduct a business such as geothermal development legally in line. Geothermal regulation is needed in developing geothermal power plant as renewable energy from green energy for cleaner environment. The purpose of this research was to analyse the geothermal regulation in Indonesia and compare with New Zealand regulation. This research was conducted using a qualitative descriptive research method. The data used in this study were taken through in-depth interviews with an expert and literature study from various relevant sources data related with Indonesia and New Zealand geothermal regulation. One of geothermal regulation in Indonesia is related to the Geothermal Working Area (GWA), where basically issued from two regimes of geothermal law, that are GWA formed prior Act No. 27/2003 and GWA formed afterward Act No. 27/2003, those geothermal regulations was changed time by time. While New Zealand has regulations namely Resource Management Act (RMA) 1991 which is the main environmental law in New Zealand. Therefore, from this research was analysed that clear regulation is needed to conduct geothermal development which is more applicable and provide benefits to geothermal developers who are fully supported by the government and stakeholders.
Improvement of bearing capacity of clay that is stabilized with bamboo charcoal powder
Authors: Alam S , Fahriani F , Apriyanti Y 
Published: December 2021

Abstract
A building construction must be built on the soil with good bearing capacity. Increasing of bearing capacity of the soil can be done by adding material of soil stabilizer. Bamboo charcoal powder was used in this study as a stabilizer for clay. The percentage of the addition of bamboo charcoal powder to clay soil in this study was 5%, 10%, and 15%. The California Bearing Ratio (CBR) test was carried out on original clay and stabilized clay to determine the bearing capacity of the soil. The results of this study as showed an increase in the CBR value of each percentage of the addition of bamboo charcoal powder. The highest CBR value was the addition of 15% bamboo charcoal powder with an increase in the CBR value of the original clay by 82.87%. The increase in the CBR value of the soil indicates that there is an increase in the bearing capacity of the clay due to the addition of bamboo charcoal powder
Water ecosystem services of Merawu Watershed, Banjarnegara, Central Java, Indonesia
Authors: Astuti H P , Suryatmojo H 
Published: December 2021

Abstract
Merawu watershed is one of the upstream areas of Serayu Watershed that serves as catchment area and protect the downstream area. In addition, the condition of natural landscape development which is accompanied by population growth potentially affects spring water ecosystem services. This study aims to determine the potential condition of spring as one of water providers in Merawu, then also to analyze the status of spring. Water balance analysis and Pollution Index (IP) analysis ecosystem services management were used. In this study, 12 springs were discovered with Kasimpar spring having the highest discharge (5.01 liters/second). The overall condition of the spring ecosystem services is one of surplus water / carrying capacity has not been exceedee (Dda ratio > 1), and the condition appropriate with water quality standards (IP <1). In conclusion, this study plays an important thing to figure it out about the existence of water ecosystem services in this area, as well as being a pioneer study on Payment for Ecosystem Services (PES) model in Banjarnegara Regency with an integrated upstream-downstrean concept and based on the principle of sustainability
Can Sanctuary Policies Reduce Domestic Violence?
Authors: Amuedo-Dorantes Catalina , Deza Monica 
Published: December 2021

AbstractDomestic violence remains a serious public problem, especially in Hispanic communities, where one in three women are victims of domestic violence in their lifetimes. Yet $&lt;$50$\%$ of victims report the incidents, often because of concerns over police officers asking about their immigration status of the status of their family members. We assess the extent to which the implementation of sanctuary policies, which limit the cooperation of local law enforcement with federal immigration authorities, affect domestic homicide rates—a crime rarely unreported. We find that sanctuary policies reduce domestic homicides with a Hispanic female victim, especially in counties with more female officers. In contrast, the effect is smaller in magnitude in counties with mandatory arrest laws for domestic violence already in place. Overall, the results are suggestive of the protective role of sanctuary policies in Hispanic communities.
Deep learning tools are top performers in long non-coding RNA prediction
Authors: Ammunét Tea , Wang Ning , Khan Sofia , Elo Laura L 
Published: December 2021

Abstract
The increasing amount of transcriptomic data has brought to light vast numbers of potential novel RNA transcripts. Accurately distinguishing novel long non-coding RNAs (lncRNAs) from protein-coding messenger RNAs (mRNAs) has challenged bioinformatic tool developers. Most recently, tools implementing deep learning architectures have been developed for this task, with the potential of discovering sequence features and their interactions still not surfaced in current knowledge. We compared the performance of deep learning tools with other predictive tools that are currently used in lncRNA coding potential prediction. A total of 15 tools representing the variety of available methods were investigated. In addition to known annotated transcripts, we also evaluated the use of the tools in actual studies with real-life data. The robustness and scalability of the tools’ performance was tested with varying sized test sets and test sets with different proportions of lncRNAs and mRNAs. In addition, the ease-of-use for each tested tool was scored. Deep learning tools were top performers in most metrics and labelled transcripts similarly with each other in the real-life dataset. However, the proportion of lncRNAs and mRNAs in the test sets affected the performance of all tools. Computational resources were utilized differently between the top-ranking tools, thus the nature of the study may affect the decision of choosing one well-performing tool over another. Nonetheless, the results suggest favouring the novel deep learning tools over other tools currently in broad use.
Serum carcinoembryonic antigen and carbohydrate antigen 19-9 as preoperative diagnostic biomarkers of extrahepatic bile duct cancer
Authors: Kim Hyeong Seok , Han Youngmin , Kang Jae Seung , Kang Yoon Hyung , Lee Mirang , Sohn Hee Ju , Kim Hongbeom , Kwon Wooil , Jang Jin-Young 
Published: December 2021

Abstract

Background
Serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 have been proposed as useful preoperative biomarkers of extrahepatic bile duct cancer (EBDC). This study investigated the accuracy of CEA and CA19-9 for preoperative diagnosis of EBDC.

Methods
Patients who underwent surgery for EBDC at a tertiary centre between 1995 and 2018 were studied, and those with concurrent hepatobiliary diseases (including gallbladder cancer, intraductal papillary mucinous neoplasms of pancreas), which could affect CEA or CA19-9 levels, were excluded. The control group included patients who underwent cholecystectomy for benign gallbladder diseases during the same period. Diagnostic accuracy was determined using sensitivity, specificity and area under the receiver operating characteristic curve (AUC).

Results
After excluding 23 patients, 687 patients (488 men and 199 women, mean age 65.8 years) were compared with the control group of 2310 patients. Median CEA and CA19-9 levels were 1.8 μg/l and 47.0 kU/l in patients with EBDC. CEA (cut-off 5.0 μg/l) showed AUC of 0.541, sensitivity 9.0 per cent and specificity 99.2 per cent, whereas CA19-9 (cut-off 37.0 kU/l) showed AUC of 0.753, sensitivity 56.2 per cent and specificity 94.5 per cent. Sensitivity of CA19-9 was lower in early (T stages 0–II) than advanced (T stages III and IV) cancer (47.0 versus 64.9 per cent), and also lower in N0 stage cancer than lymph node metastasis (50.1 versus 68.8 per cent).

Conclusion
Serum CEA and CA19-9 showed low sensitivity limiting their usefulness as diagnostic biomarkers of EBDC.
Tenofovir Alafenamide Plasma Concentrations Are Reduced in Pregnant Women Living With Human Immunodeficiency Virus (HIV): Data From the PANNA Network
Authors: Bukkems Vera E , Necsoi Coca , Hidalgo Tenorio Carmen , Garcia Coral , Alba Alejandre Irene , Weiss Fabian , Lambert John S , van Hulzen Astrid , Richel Olivier , te Brake Lindsey H M , van der Meulen Eric , Burger David , Konopnicki Deborah , Colbers Angela 
Published: December 2021

Abstract

Background
Tenofovir alafenamide (TAF), a prodrug of tenofovir (TFV), is included in the majority of the recommended first-line antiretroviral regimens for patients living with human immunodeficiency virus (HIV), but there are limited data on TAF use in pregnant women. We aimed to examine the plasma pharmacokinetics of TAF and TFV in pregnant women from Europe.

Methods
Pregnant women living with HIV were included from treatment centers across Europe, and intensive pharmacokinetic sampling in the third trimester and postpartum was performed. Pharmacokinetic parameters of TAF and TFV were determined with noncompartmental analysis. The proportion of women with a TAF area under the curve (AUClast) below the target of 53.1 ng∗h/mL was determined. Clinical efficacy and safety outcome parameters were reported.

Results
In total, 20 pregnant women living with HIV were included. At the third trimester, geometric mean TAF AUClast and Cmax were decreased by 46% and 52%, respectively, compared with postpartum. TFV AUC0-24h, Cmax, and Ctrough decreased by 33%, 30%, and 34%, respectively. The proportion of women with a TAF AUClast &lt; 53.1 ng∗h/mL was 6% at third trimester and 0% postpartum. One out of 20 women had a viral load &gt; 50 copies/mL at third trimester and no mother-to-child transmission occurred.

Conclusions
TAF plasma concentrations were reduced by about half in women living with HIV during third trimester of pregnancy but remained above the predefined efficacy target in the majority of the pregnant women. TFV concentrations were reduced by approximately 30% during third trimester. Despite the observed exposure decrease, high virologic efficacy was observed in this study.
Circulating Ubiquitous RNA, A Highly Predictive and Prognostic Biomarker in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients
Authors: Bruneau Thomas , Wack Maxime , Poulet Geoffroy , Robillard Nicolas , Philippe Aurélien , Puig Pierre Laurent , Bélec Laurent , Hadjadj Jérôme , Xiao Wenjin , Kallberg Julia Linnea , Kernéis Solen , Diehl Jean Luc , Terrier Benjamin , Smadja David M , Taly Valerie , Veyer David , Péré Hélène 
Published: December 2021

Abstract

Background
Approximately 15–30% of hospitalized coronavirus disease 2019 (COVID-19) patients develop acute respiratory distress syndrome, systemic tissue injury, and/or multi-organ failure leading to death in around 45% of cases. There is a clear need for biomarkers that quantify tissue injury, predict clinical outcomes, and guide the clinical management of hospitalized COVID-19 patients.

Methods
We herein report the quantification by droplet-based digital polymerase chain reaction (ddPCR) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNAemia and the plasmatic release of a ubiquitous human intracellular marker, the ribonuclease P (RNase P) in order to evaluate tissue injury and cell lysis in the plasma of 139 COVID-19 hospitalized patients at admission.

Results
We confirmed that SARS-CoV-2 RNAemia was associated with clinical severity of COVID-19 patients. In addition, we showed that plasmatic RNase P RNAemia at admission was also highly correlated with disease severity (P &lt; .001) and invasive mechanical ventilation status (P &lt; .001) but not with pulmonary severity. Altogether, these results indicate a consequent cell lysis process in severe and critical patients but not systematically due to lung cell death. Finally, the plasmatic RNase P RNA value was also significantly associated with overall survival.

Conclusions
Viral and ubiquitous blood biomarkers monitored by ddPCR could be useful for the clinical monitoring and the management of hospitalized COVID-19 patients. Moreover, these results could pave the way for new and more personalized circulating biomarkers in COVID-19, and more generally in infectious diseases, specific from each patient organ injury profile.
Time to Flexible Sigmoidoscopy or Colonoscopy in Patients Admitted With Ulcerative Colitis Has Decreased From 2012 to 2018
Authors: Bali Aman S , Picco Michael F , Hashash Jana G , Farraye Francis A , Kröner Paul T 
Published: December 2021

Abstract

Background
Early endoscopic evaluation of patients with ulcerative colitis (UC) enables assessment of disease activity and accurate diagnosis based on exclusion of other similarly presenting conditions including infections. Early endoscopy is also associated with improved outcomes of patients with active UC. The aim of this study was determining temporal trends in endoscopy in patients with UC over a 7-year period from 2012 to 2018.

Methods
Retrospective cohort study using the National Inpatient Sample 2012–2018. Patients admitted with ICD-9–10 principal codes for UC were included. Early endoscopy using flexible sigmoidoscopy (FS) or colonoscopy was defined as performed within 48 hours of admission. The primary outcome was trends in endoscopy timing. Secondary outcomes were inpatient morbidity, mortality, length of stay (LOS), and hospitalization charges/costs comparing patients undergoing early vs nonearly endoscopy using multivariable regression.

Results
Of 222 460 patients hospitalized with UC, 5900 (2.7%) underwent FS and 43 345 (19.5%) underwent colonoscopy. The rate of endoscopy increased from 3.9% (2.3% early) to 39.3% (23.3% early) from 2012 to 2018 (P &lt; .01). Early endoscopy was associated with statistically significant decreased mortality, shock, multiorgan failure, and intensive care unit odds, as well as decreased resource utilization and LOS.

Conclusions
In patients hospitalized with UC, early endoscopy rates were low but performed more frequently from 2012 to 2018. This may reflect increasing awareness of improved outcomes from earlier disease staging and/or diagnosis. Early endoscopy was associated with decreased resource utilization and hospitalization-related outcomes, highlighting the importance of early endoscopy in patients admitted with UC.
Slow periodic oscillation without radiation damping: new evolution laws for rate and state friction
Authors: Mizushima Ryo , Hatano Takahiro 
Published: December 2021

SUMMARY
The dynamics of sliding friction is mainly governed by the frictional force. Previous studies have shown that the laboratory-scale friction is well described by an empirical law stated in terms of the slip velocity and the state variable. The state variable represents the detailed physicochemical state of the sliding interface. Despite some theoretical attempts to derive this friction law, there has been no unique equation for time evolution of the state variable. Major equations known to date have their own merits and drawbacks. To shed light on this problem from a new aspect, here we investigate the feasibility of periodic motion without the help of radiation damping. Assuming a patch on which the slip velocity is perturbed from the rest of the sliding interface, we prove analytically that three major evolution laws fail to reproduce stable periodic motion without radiation damping. Furthermore, we propose two new evolution equations that can produce stable periodic motion without radiation damping. These two equations are scrutinized from the viewpoint of experimental validity and the relevance to slow earthquakes.
An interactive video increasing French students’ mental health literacy: a mixed-methods randomized controlled pilot study
Authors: Queroue Marine , Pouymayou Aude , Pereira Edwige , Tzourio Christophe , González-Caballero Juan Luis , Montagni Ilaria 
Published: December 2021

Summary
Mental health literacy (MHL) is a determinant of psychological well-being in young people. A randomized controlled design was used to evaluate the appreciation and effectiveness of an interactive video on French University students’ MHL (knowledge about depression and suicidal behavior, mental health help-seeking behaviors, stigma and misconceptions about mental health). At the baseline, all participants (n = 101) completed a questionnaire including several scales on MHL. One month after, participants were randomly assigned to two homogeneous groups (intervention, n = 50 or control, n = 51) and again completed the questionnaire on MHL. Through a mixed-methods approach, semi-structured interviews were also conducted with the intervention group to collect information on the appreciation of the interactive video. Quantitative data indicated that MHL scores increased or remained stable in the intervention group. Comparison with the control group and multivariate logistic regression models did not show statistically significant differences, due to the small sample of the study. According to qualitative data, users appreciated the content and the format of the intervention. It was suggested that the video could be disseminated in other University campuses in France and internationally to promote MHL among students.