bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining Racial Disparities in Historical Change of Mental and Physical Health Across Midlife and Old Age in the United States
Authors: Staben Omar E , Infurna Frank J , Lachman Margie E , Gerstorf Denis 
Published: December 2021

AbstractObjectivesTo examine whether racial disparities are narrowing or widening with historical time among U.S. middle-aged and older adults, and test the extent to which educational attainment moderates racial disparities over historical time.MethodsMultilevel models were applied to longitudinal data on middle-aged (ages 40–65) and older adults (ages 66 and older) from the Health and Retirement Study. Historical change was indexed as cohort or birth year. The outcomes of focus were depressive symptoms, episodic memory, health conditions, functional limitations, and self-rated health.ResultsResults revealed a differential pattern of racial disparities in historical change between midlife and old age. Across midlife and old age, on average, Blacks and Hispanics reported poorer levels of mental and physical health, compared with Whites. In midlife, racial disparities narrowed with historical time; later-born cohorts of Hispanics but not Whites reported fewer depressive symptoms than their earlier-born peers. Likewise, historical improvements in health were stronger among Hispanics and Blacks than Whites. Conversely, in old age, later-born cohorts across race consistently showed historical improvements in each of the outcomes examined. Regarding educational attainment, we observed little consistent evidence that health-promoting effects of educational attainment differ across race and cohort. Examining questions about heterogeneity, results revealed that in midlife and old age there was greater heterogeneity between race across each of the outcomes.DiscussionOur discussion elaborates on reasons behind the documented racial differences in historical changes among U.S. middle-aged and older adults, and how the protective role of education is changing over time.
Elevated plasma complement components in facioscapulohumeral dystrophy
Authors: Wong Chao-Jen , Wang Leo , Holers V Michael , Frazer-Abel Ashley , van der Maarel Silvère M , Tawil Rabi , Statland Jeffrey M , Tapscott Stephen J ,   ReSolve Network
Published: December 2021

Abstract
Advances in understanding the pathophysiology of facioscapulohumeral dystrophy (FSHD) have led to several therapeutic approaches entering clinical trials and an increased need to develop biomarkers of disease activity and progression. Multiple prior studies have shown early elevation of RNAs encoding components of the complement pathways and relatively widespread activated complement complexes by immunodetection in FSHD muscle. The current study tested plasma from two independent cohorts of FSHD and control subjects and found elevated complement components in both FSHD cohorts. Combining subjects from both cohorts identified complement factors that best distinguished FSHD and controls. Within the FSHD group, a subset of subjects showed elevation in multiple complement components. Together these findings suggest the need for future studies to determine whether measurements of complement activation can be used as a non-invasive measurement of FSHD disease activity, progression and/or response to therapies. In addition, with the ongoing expansion of complement therapeutic approaches, consideration for precision-based targeting of this pathway is appropriate.
Impact of counterclockwise rotation of the right middle lobe following right upper lobectomy
Authors: Koike Sachie , Eguchi Takashi , Matsuoka Shunichiro , Takeda Tetsu , Miura Kentaro , Shimizu Kimihiro , Hamanaka Kazutoshi 
Published: December 2021

Abstract

OBJECTIVES
Following right upper lobectomy, the right middle lobe may shift towards the apex and rotate in a counterclockwise direction with respect to the hilum. This study aimed to investigate the incidence and clinical impact of middle lobe rotation in patients undergoing right upper lobectomy.

METHODS
From January 2014 to November 2018, 82 patients underwent right upper lobectomy at our institution for lung cancer using a surgical stapler to divide the minor fissure. Postoperative computed tomography scans evaluated the counterclockwise rotation of the middle lobe, in which the staple lines placed on the minor fissure were in contact with the major fissure of the right lower lobe (120° counterclockwise rotation). Clinicoradiological factors were evaluated and compared between patients with and without middle lobe rotation. We also reviewed surgical videos in patients with middle lobe rotation to evaluate the position of the middle lobe at the end of surgery.

RESULTS
Nine patients had a middle lobe rotation (11%), where 1 patient required surgical derotation. Patients with middle lobe rotation were significantly associated with more frequent right middle lobe atelectasis and severe postoperative complications compared with those without rotation. A surgical video review detected potential middle lobe rotation at the end of the surgery.

CONCLUSIONS
Middle lobe rotation without torsion following right upper lobectomy is not rare, and it is associated with adverse postoperative courses. Careful positioning of the right middle lobe at the end of surgery is warranted to improve postoperative outcomes.
The Private Is Political: Partisan Persuasion through Mobile Instant Messaging Services
Authors: Lobera Josep , Portos Martín 
Published: December 2021

AbstractThe use of mobile instant messaging services (MIMS) for the dissemination of electoral information has been increasing in recent years. Drawing on a novel dataset from a 2015 post-electoral survey in Spain, we focus on individuals’ digital political behavior, both public and private. Our results show that, in a context of high electoral volatility and polarization, right-wing supporters are willing to engage in political persuasion activities using tools such as MIMS in the private digital arena but not publicly (e.g., on social media). In contrast, left-wing milieus develop mobilization efforts in both public and private settings. We argue that distinct political styles are key in accounting for the difference in channels of partisan persuasion, in which preference falsification mechanisms are involved in the public sphere. These results bear important implications for the understanding of false information exchanges in the private sphere, social media activism, and political participation. Additionally, they help us shed light on the recurring failure of polls in capturing electoral behavior among right-wing voters in polarized elections and referenda.
Mycobacterium tuberculosis-Specific T-Cell Responses Are Impaired During Late Pregnancy With Elevated Biomarkers of Tuberculosis Risk Postpartum
Authors: Saha Aparajita , Escuduero Jaclyn , Layouni Troy , Richardson Barbra , Hou Sharon , Mugo Nelly , Mujugira Andrew , Celum Connie , Baeten Jared M , Lingappa Jairam , John-Stewart Grace C , LaCourse Sylvia M , Shah Javeed A 
Published: December 2021

Abstract

Background
Pregnancy is a risk factor for progression from latent tuberculosis infection to symptomatic tuberculosis. However, how pregnancy influences T-cell responses to Mycobacterium tuberculosis is unknown.

Methods
We measured M. tuberculosis-specific cytokines, T-cell memory markers, and overall CD4+ and CD8+ T-cell activation by flow cytometry from 49 women (18 with and 31 without HIV) who became pregnant while enrolled in a randomized controlled trial of preexposure prophylaxis for HIV. We analyzed data using COMPASS, an established statistical method for evaluating overall antigen-specific T-cell responses.

Results
Pregnant women with latent tuberculosis infection demonstrated significantly diminished M. tuberculosis-specific CD4+ cytokine responses in the third trimester (COMPASS polyfunctional score [PFS], 0.07) compared before (PFS, 0.15), during (PFS, 0.13 and 0.16), and after pregnancy (PFS, 0.14; P = .0084, Kruskal-Wallis test). Paradoxically, M. tuberculosis-specific CD8+ cytokines and nonspecifically activated T-cells increased during late pregnancy. Nonspecific T-cell activation, a validated biomarker for progression from latent tuberculosis infection to tuberculosis disease, increased in latent tuberculosis infection-positive women postpartum, compared with latent tuberculosis infection-negative women.

Conclusions
Pregnancy-related functional T-cell changes were most pronounced during late pregnancy. Both M. tuberculosis-specific T-cell changes during pregnancy and increases in immune activation postpartum may contribute to increased risk for tuberculosis progression.

Clinical Trials Registration
NCT0557245.
Similar Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Similar Nucleocapsid Antibody Levels in People With Well-Controlled Human Immunodeficiency Virus (HIV) and a Comparable Cohort of People Without HIV
Authors: Verburgh Myrthe L , Boyd Anders , Wit Ferdinand W N M , Schim van der Loeff Maarten F , van der Valk Marc , Bakker Margreet , Kootstra Neeltje A , van der Hoek Lia , Reiss Peter 
Published: December 2021

Abstract

Background
Within the ongoing AGEhIV Cohort Study in Amsterdam, we prospectively compared the incidence of and risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection between human immunodeficiency virus (HIV)–positive and HIV-negative participants. Moreover, we compared SARS-CoV-2 nucleocapsid antibody levels between participants with incident infection from both groups.

Methods
Starting in September 2020, consenting HIV-positive and HIV-negative participants were assessed every 6 months for incident SARS-CoV-2 infection, using combined immunoglobulin (Ig) A/IgM/IgG SARS-CoV-2 nucleocapsid antibody assay. Cumulative incidence of SARS-CoV-2 infection and associated risk factors were assessed from 27 February 2020 through 30 April 2021, using complementary log-log regression. In those with incident SARS-CoV-2 infection, nucleocapsid (N) antibody levels were compared between groups using linear regression.

Results
The study included 241 HIV-positive (99.2% virally suppressed) and 326 HIV-negative AGEhIV participants. The cumulative SARS-CoV-2 incidence by April 2021 was 13.4% and 11.6% in HIV-positive and HIV-negative participants, respectively (P = .61). Younger age and African origin were independently associated with incident infection. In those with incident infection, only self-reported fever, but not HIV status, was associated with higher N antibody levels.

Conclusions
HIV-positive individuals with suppressed viremia and adequate CD4 cell counts had similar risk of SARS-CoV-2 acquisition and similar SARS-CoV-2 N antibody levels after infection compared with a comparable HIV-negative cohort.

Clinical Trial Registration
NCT01466582.
Cruel Intentions: Liberal Logics and Processes of International Criminalization
Authors: Han Yuna , Nantermoz Olivia 
Published: December 2021

AbstractThe prohibition and prosecution of core international crimes are understood as a liberal response to particularly cruel acts that shock the conscience of humanity. But what is the nature of this cruelty and how does it relate to liberalism? Rather than seeing liberalism as monolithic, we examine the different relationships between liberal logics and cruelty and how they manifest in processes of international criminalization. We develop a three-pronged typology of liberalism(s) based on their constitutive relationship to cruelty. The first logic expands upon Judith Shklar's theory of “Liberalism of Fear” that sees cruelty as detrimental to liberal society, foregrounding particularly acute forms of physical and affective cruelty in liberal politics and law; the second logic, “Racial Liberalism,” understands cruelty as a condition of possibility for the liberal order built on the exploitation of racialized others; and the third conceives of cruelty as produced by the market logic of trade-offs, referred to as “Sacrificial Liberalism.” Based on this framework, we examine two processes of international criminalization: the crime of genocide (widely considered to be the “crime of crimes” and thus an emblematic case of criminalized cruelty directed against collective identities) and the crime of aggression (which followed a more complicated criminalization trajectory). By tracing how different liberal logics interrelate, come into tension, and thus shape the processes of international criminalization, we not only illuminate the shifting legitimations and normative priorities of the liberal international order but also confront the normative value of criminalizing cruelty.
Prediction of the Values of CRP, eGFR, and Hemoglobin in the Follow-Up of Renal Cell Carcinoma Patients after (Cryo)Surgery Using Machine Learning Algorithms
Authors: Bosma Madeleen , Jansen Swetta A , Gawel Job H , van Dullemen Coen E M , Priems Margrite M , Westerhof Alisa , Meijer Aswin R , Ruven Henk J T 
Published: December 2021

Abstract

Background
Artificial intelligence can support clinical decisions by predictive modeling. Using patient-specific characteristics, models may predict the course of clinical parameters, thus guiding monitoring approaches for the individual patient. Here, we present prediction models for inflammation and for the course of renal function and hemoglobin (Hb) in renal cell carcinoma patients after (cryo)surgery.

Methods
Using random forest machine learning in a longitudinal value-based healthcare data set (n = 86) of renal cell carcinoma patients, prediction models were established and optimized using random and grid searches. Data were split into a training and test set in a 70:30 ratio. Inflammation was predicted for a single timepoint, whereas for renal function estimated glomerular filtration rate (eGFR) and Hb time course prediction was performed.

Results
Whereas the last Hb and eGFR values before (cryo)surgery were the main basis for the course of Hb and renal function, age and several time frame features also contributed significantly. For eGFR, the type of (cryo)surgery was also a main predicting feature, and for Hb, tumor location, and body mass index were important predictors. With regard to prediction of inflammation no feature was markedly prominent. Inflammation prediction was based on a combination of patient characteristics, physiological parameters, and time frame features.

Conclusions
This study provided interesting insights into factors influencing complications and recovery in individual renal cell carcinoma patients. The established prediction models provide the basis for development of clinical decision support tools for selection and timing of laboratory analyses after (cryo)surgery, thus contributing to quality and efficiency of care.
Transesterification of Indazole-3-carboxamide Synthetic Cannabinoids: Identification of Metabolite Biomarkers for Diagnosing Co-abuse of 5F-MDMB-PINACA and Alcohol
Authors: Wang Ziteng , Fong Ching Yee , Goh Evelyn Mei Ling , Moy Hooi Yan , Chan Eric Chun Yong 
Published: December 2021

Abstract
Concurrent use of alcohol with synthetic cannabinoids (SCs) has been widely recorded among drug abusers. The susceptibilities of three indazole-3-carboxamide type SCs with methyl ester moiety, 5F-MDMB-PINACA, 5F-MMB-PINACA, and MMB-FUBINACA, to transesterification in the presence of ethanol warranted further investigation in view of probable augmented toxicity. In vitro metabolite identification experiments were first performed using human liver microsomes (HLMs) to characterize the novel metabolites of the three parent SCs in the presence of ethanol. Formation of transesterified metabolite, hydrolyzed metabolite, and several oxidative metabolites in HLM in the presence of alcohol was further determined for each parent SC and the respective ethyl ester analog, 5F-EDMB-PINACA, 5F-EMB-PINACA, and EMB-FUBINACA, to quantitatively elucidate transesterification and hydrolysis activities. Our results suggested that all three SCs undergo carboxylesterase-mediated transesterification to their respective ethyl ester analog in the presence of ethanol, which was incubation time- and ethanol concentration-dependent. Each ethyl ester metabolite was sequentially and readily metabolized to novel oxidative metabolites with the intact ethyl ester moiety and the same hydrolyzed metabolite as derived from its parent SC. A smaller extent of transesterification was non-enzymatically driven. Notably, we proposed 5F-EDMB-PINACA oxidative defluorination metabolite as the biomarker for diagnosing the potential co-abuse of 5F-MDMB-PINACA and alcohol. Due to the comparable pharmacological activities between each SC and its ethyl ester metabolite, augmented toxicity associated with co-abuse of SCs and alcohol is probable and deserves further investigation.
Computational co-design framework for coreless wound fibre–polymer composite structures
Authors: Gil Pérez M , Zechmeister C , Kannenberg F , Mindermann P , Balangé L , Guo Y , Hügle S , Gienger A , Forster D , Bischoff M , Tarín C , Middendorf P , Schwieger V , Gresser G T , Menges A , Knippers J 
Published: December 2021

AbstractIn coreless filament winding, resin-impregnated fibre filaments are wound around anchor points without an additional mould. The final geometry of the produced part results from the interaction of fibres in space and is initially undetermined. Therefore, the success of large-scale coreless wound fibre composite structures for architectural applications relies on the reciprocal collaboration of simulation, fabrication, quality evaluation, and data integration domains. The correlation of data from those domains enables the optimization of the design towards ideal performance and material efficiency. This paper elaborates on a computational co-design framework to enable new modes of collaboration for coreless wound fibre–polymer composite structures. It introduces the use of a shared object model acting as a central data repository that facilitates interdisciplinary data exchange and the investigation of correlations between domains. The application of the developed computational co-design framework is demonstrated in a case study in which the data are successfully mapped, linked, and analysed across the different fields of expertise. The results showcase the framework’s potential to gain a deeper understanding of large-scale coreless wound filament structures and their fabrication and geometrical implications for design optimization.
Nutritional and Physiological Regulation of Glassy-Winged Sharpshooter Oogenesis
Authors: Sisterson Mark S , Brent Colin S 
Published: December 2021

Abstract
The glassy-winged sharpshooter (Homalodisca vitripennis (Germar); Hemiptera: Cicadellidae: Cicadellinae) is an invasive insect that transmits the plant pathogenic bacterium Xylella fastidiosa Wells et al. (Xanthomonadales: Xanthomonadacae). While adult glassy-winged sharpshooter must feed to produce eggs, the role of nutritional status on initiating oogenesis is poorly understood. To determine the effects of glassy-winged sharpshooter nutrition on nymphal development, oogenesis, and fecundity, glassy-winged sharpshooter were reared on cowpea, sunflower, sorghum, and a mixture of the three plant species. Adults emerging from cowpea, sunflower, or plant mixture treatments had shorter development times, attained larger size, and had greater estimated lipid reserves than females reared on sorghum. In choice tests, nymphs avoided sorghum and preferentially fed on cowpea and sunflower. Adult females provisioned with a single plant species during the nymphal stage were provided with either the same host plant species or a mixture of host plant species (cowpea, sunflower, sorghum) for a 9-wk oviposition period, with 37% of females initiating oogenesis. Ovipositing females had greater juvenile hormone and octopamine levels than reproductively inactive females, although topical application of the juvenile hormone analog Methoprene did not promote oogenesis. Across nymphal diets, reproductively active females produced more eggs when held on plant mixtures than on single plant species. In choice tests, adult females were observed most frequently on cowpea, although most eggs were deposited on sorghum, the host least preferred by nymphs. Results suggest that fecundity is largely determined by the quality of the adult diet, although the stimulus that initiates oogenesis does not appear to be related to nutrition.
Cold Tolerance of Immature Stages ofCeratitis capitataandBactrocera dorsalis(Diptera: Tephritidae)
Authors: Manrakhan Aruna , Daneel John-Henry , Stephen Peter R , Hattingh Vaughan 
Published: December 2021

AbstractBactrocera dorsalis (Hendel) is a new fruit fly pest of some fruit types in the north and north eastern areas of South Africa. In order to determine whether existing cold disinfestation treatment schedules for an indigenous fruit fly pest: Ceratitis capitata (Wiedemann) would be effective for B. dorsalis, cold tolerances of four immature stages of the two species were compared. Studies were done in an artificial carrot-based larval diet. The developmental rates of the immature stages of the two species in the carrot-based larval diet were first determined at a constant temperature of 26°C. The developmental times for eggs and three larval stages were found to be similar for the two species. Incubation times of both species after egg inoculation were determined to be 0, 3, 4, and 6 d for obtaining egg, first larval, second larval, and third larval stages respectively for the cold treatment. At a test temperature of –0.6°C, mortality rates of C. capitata eggs, first instars, second instars, and third instars were lower than those of B. dorsalis. These results demonstrate that the current cold treatment schedules for disinfestation of C. capitata can be used as equally or more efficacious treatments for B. dorsalis.
Enhancing Health Equity Through Cancer Health Economics Research
Authors: Bradley Cathy J , Simon Kosali , Winkfield Karen , Moy Beverly 
Published: December 2021

Abstract
Cancer displays some of the largest health-equity concerns of all diseases. This paper draws attention to how health economics research can assess strategies to reduce or even eliminate health disparities and provides pivotal examples of existing research as well as areas for future contributions. The paper also highlights critical data limitations that currently restrain the impact health economics research could have. We then explore new areas of inquiry where economic research is sparse but could have an important impact on health equity, particularly in topics involving Medicare and Medicaid policies that expand reimbursement and generosity of coverage. Health economics studies are notably absent from policies and practices surrounding clinical trials, representing an opportunity for future research. We urge health economics researchers to consider experiments, interventions, and assessments through primary data collection; we further encourage the formulation of multidisciplinary teams to ensure that health economics skills are well melded with other areas of expertise. These teams are needed to maximize novelty and rigor of evidence. As policies are promulgated to address disparities in cancer, involvement of economics in a multidisciplinary context can help ensure that these policies do not have unintended impacts that may deepen inequities.