bluuebunny/crossref_metadata_2025_split huggingface dataset:
Appalachian coal bed palynofloras: changes in composition through time and comparison with other areas
Authors: Eble Cortland F. 
Published: October 2021

Abstract

This paper presents a summary of palynological data for Pennsylvanian age coal beds in the Appalachian Basin, discussed primarily from a biostratigraphic perspective. Coal bed palynofloras of Lower Pennsylvanian through early Permian age are compared and correlated with miospore assemblage zones established for western Europe, and the Eastern Interior (Illinois) and Western Interior Basins of the mid-continent USA. Lower Pennsylvanian palynofloras, which are dominated by lycopsid spores, are correlative with the Langsettian of western Europe and the Morrowan of the Eastern and Western Interior mid-continent USA Basins. Stratigraphically useful palynotaxa include
Dictyotriletes bireticulatus
,
Radiizonates striatus
,
Schulzospora rara
,
Granasporites medius
,
Laevigatosporites minor
and
Endosporites globiformis
. Middle Pennsylvanian palynofloras change through time, being lycopsid dominant in the lower part and more heterogeneous in the middle and upper parts with increased contributions from other Pennsylvanian plant groups. They are correlative with the Duckmantian, Bolsovian and Asturian of western Europe and the Atokan and Desmoinesian of the Eastern and Western Interior mid-continent USA Basins. Stratigraphically useful palynotaxa include
Secarisporites remotus
,
Microreticulatisporites sulcatus
,
Vestispora fenestrata
,
Triquitrites sculptilis
,
Laevigatosporites globosus
,
Radiizonates difformis
,
Torispora securis
,
Triquitrites minutus
,
Mooreisporites inusitatus
,
Murospora kosankei
,
Thymospora pseudothiessenii
and
Schopfites dimorphus
. Upper Pennsylvanian and lower Permian coal beds in the Appalachian Basin, in contrast to their Lower and Middle Pennsylvanian counterparts, are strongly dominated by tree fern spore palynotaxa. Palynofloras correlate with the Stephanian and Autunian of western Europe and the Missourian, Virgilian and Wolcampian of the Eastern and Western Interior mid-continent USA Basins.
Application Value of Rehabilitation Nursing in Patients with Stroke Based on the Theory of Interactive Standard: A Randomized Controlled Study
Authors: Li Ningning , Wang Jun , Zheng Mei , Ge Qunying 
Published: October 2021

Objective. To explore the application value of rehabilitation nursing based on the theory of interactive standards in stroke patients. Methods. A total of 120 stroke patients who were treated in our hospital from December 2018 to September 2020 were selected as the research objects, and the patients were divided into a control group (60 cases) and an observation group (60 cases) according to the random number table method. The control group used routine nursing care, and the observation group used interactive rehabilitation care based on the control group. The Barthel Index, National Institute of Health Stroke Scale (NIHSS) score, Specific Quality Of Life Scale (SS-QOL) score, rehabilitation standard rate, nursing satisfaction, improvement time of limb function, and compliance with rehabilitation exercise were compared between the two groups of patients. Results. After intervention, the Barthel Index of the two groups increased, and the Barthel Index of the observation group was comparatively higher (

P

< 0.05); the NIHSS scores of the two groups of patients reduced, and the NIHSS scores of the observation group were significantly lower than those of the control group (

P

< 0.05); the SS-QOL scores of the two groups of patients improved, and the increase in SS-QOL scores in the observation group was found to be significantly higher than those in the control group (

P

< 0.05); the compliance rate was found to be in favor of the observation group (83.33 (50/60) vs 63.33 (38/60)) (χ2 = 6.136,

P

˂0.05); the total satisfaction of nursing care of patients in the observation group was superior to the control group (96.67% vs 78.33%) (χ2 = 9.219,

P

˂0.05); the limb function improvement time of the observation group was significantly shorter (

P

< 0.05); the observation group had significantly higher rehabilitation exercise compliance scores (

P

< 0.05). Conclusion. The rehabilitation nursing based on the interactive standard theory can promote the stroke patients to complete the rehabilitation goals, improve the neurological and limb functions, and enhance the patients’ daily living ability, quality of life, and nursing satisfaction, which is worthy of clinical promotion and application.
Therapeutic Exon Skipping Through a CRISPR-Guided Cytidine Deaminase Rescues Dystrophic Cardiomyopathy in Vivo
Authors: Li Jia , Wang Kaiying , Zhang Yuchen , Qi Tuan , Yuan Juanjuan , Zhang Lei , Qiu Han , Wang Jinxi , Yang Huang-Tian , Dai Yi , Song Yan , Chang Xing 
Published: October 2021

Background:
Loss of dystrophin protein causes Duchenne muscular dystrophy (DMD), characterized by progressive degeneration of cardiac and skeletal muscles, and mortality in adolescence or young adulthood. Although cardiac failure has risen as the leading cause of mortality in patients with DMD, effective therapeutic interventions remain underdeveloped, in part, because of the lack of a suitable preclinical model.

Methods:

We analyzed a novel murine model of DMD created by introducing a 4-bp deletion into exon 4, one of the exons encoding the actin-binding domain 1 of dystrophin (referred to as
Dmd
E4*
mice). Echocardiography, microcomputed tomography, muscle force measurement, and histological analysis were performed to determine cardiac and skeletal muscle defects in these mice. Using this model, we examined the feasibility of using a cytidine base editor to install exon skipping and rescue dystrophic cardiomyopathy in vivo. AAV9-based CRISPR/Cas9-AID (eTAM) together with AAV9-sgRNA was injected into neonatal
Dmd
E4*
mice, which were analyzed 2 or 12 months after treatment to evaluate the extent of exon skipping, dystrophin restoration, and phenotypic improvements of cardiac and skeletal muscles.

Results:

Dmd
E4*
mice recapitulated many aspects of human DMD, including shortened life span (by ≈50%), progressive cardiomyopathy, kyphosis, profound loss of muscle strength, and myocyte degeneration. A single-dose administration of AAV9-eTAM instituted >50% targeted exon skipping in the
Dmd
transcripts and restored up to 90% dystrophin in the heart. As a result, early ventricular remodeling was prevented and cardiac and skeletal muscle functions were improved, leading to an increased life span of the
Dmd
E4*
mice. Despite gradual decline of AAV vector and base editor expression, dystrophin restoration and pathophysiological rescue of muscular dystrophy were long lasted for at least 1 year.

Conclusions:
Our study demonstrates the feasibility and efficacy to institute exon skipping through an enhanced TAM (eTAM) for therapeutic application(s).
Global Religious History as a Rhizome: Colonial Panics and Political Islam in German East Africa
Authors: Haustein Jörg 
Published: October 2021

Abstract
A Global History of Religion aims to trace connections, controversies, and contingencies in the emergence of “religion” as a global category. Its main intention is to de-center European epistemologies of religion by drawing out a more intricate global and plural genealogy. This is a very complex endeavour, however, especially when one leaves the realm of academic debate and considers the quotidian understandings of “religion” emerging in colonial encounters. Here one is often confronted by vast entanglements of practices, perceptions and politics, which need a historical methodology that foregrounds the plurality, complexity and historicity of all religious epistemes. Drawing on Deleuze’ and Guattari’s philosophical figure of the rhizome, this article sketches such an approach in a conversation between theory and historiographical practice, as it maps out a particular episode in the construction of “political Islam” in German East Africa.
Impact of the South Asian Adolescent Diabetes Awareness Program (SAADAP) on diabetes knowledge, risk perception and health behaviour
Authors: Banerjee Ananya Tina , Mahajan Anisha , Mathur-Balendra Avantika , Qureshi Nazima , Teekah Marlon , Yogaratnam Shindujan , Prabhakar Priya , Ahmed Sabeeha , Shah Baiju R , Velummailum Russanthy , Price Jennifer AD , de Souza Russell J , Bajaj Harpreet S 
Published: October 2021

Objective: Evidence suggests the increased prevalence of diabetes among South Asian (SA) adolescents is due to their genetic risk profile. The South Asian Adolescent Diabetes Awareness Program (SAADAP) is a pilot intervention for SA youth in Canada with a family history of type 2 diabetes mellitus (T2DM). We sought to investigate changes in (1) diabetes knowledge and associated risk factors, (2) risk perception and (3) health behaviours among adolescents participating in SAADAP. Design: One-group pre-test, post-test design informed by a commitment to community-based participatory research (CBPR). Setting: Sixty-eight adolescents aged 13–17 years with a family history of T2DM participated in SAADAP in a clinical-community setting in Canada. Method: Pre–post questionnaires were administered to evaluate diabetes knowledge and associated risk factors, risk perceptions and health behaviours. Analyses were restricted to 49 participants who attended at least four diabetes education sessions. Results: The mean age of adolescents was 14.5 years, and 57.1% self-identified as girls. The difference in knowledge about the definition, symptoms and complications of T2DM from baseline to post-intervention was 3.32 out of 21 ( p < .001) among SA youth. There was significant increase in learning about diabetes risk factors ( p < .001) from baseline to post-intervention. Almost 60% of participants exhibited no change in their risk perception after intervention. Approximately two-thirds of the participants self-reported positive changes in health behaviours after completing the programme. Conclusion: SAADAP showed promising outcomes in raising knowledge and improving health behaviours in SA adolescents with a family history of diabetes. Larger controlled trials with longer follow-up are recommended to support and expand on the current findings.
The practice of motivated reasoning: observing knowledge use in real-world policy processes
Authors: Dorren Lars , Böhme Mirijam 
Published: October 2021

Motivated reasoning theory is a psychological theory that reads that policymakers interpret evidence in ways that fit their preferences rather than assessing it neutrally. The theory is increasingly used to explain policy processes as part of a behavioural approach to public administration, but it has limitations. As psychological research relies on experiments, the question remains what role motivated reasoning plays in real-world policy processes. Based on ethnographic observations collected during the planning phase of a large infrastructure project, this study confirms that motivated reasoning explains how people interpret information. However, it also shows that peoples’ context has a great impact on their reasoning. Ultimately, we suggest that a focus on time and real-world context is essential in understanding processes of reasoning, for which methodological diversification is needed. Points for practitioners People are inclined to interpret information in light of existing attitudes, rather than approach it neutrally. They read it in such a way that it confirms their attitudes, or are critical of it when it does not. Conflicts caused by differentiating views can be better understood by looking at the attitudes that inform these views. Discussions that might seem aimless at first might have secondary functions such as building trust amongst participants.
The wavenumber imaging of fiber waviness in hybrid glass–carbon fiber reinforced polymer composite plates
Authors: Zhang Haiyan , Ren Yan , Song Jiaxin , Zhu Qi , Ma Xuefen 
Published: October 2021

Out-of-plane waviness is one of the most common defects which degenerates the strength, stiffness, and fatigue life of hybrid glass–carbon fiber–reinforced polymer composites (FRPs). An accurate and high-speed non-destructive testing method is highly desired for large composite structures in industries. Ultrasonic phased array is a great candidate for such application. This paper applies the wavenumber algorithm to image the waviness in hybrid FRP plates which are a multi-layered medium. The central frequency of 5 MHZ is chosen in order to maximize the ply resonance. Transducers are migrated virtually to each interface between glass and carbon plies in order to overcome the difficulty of wave propagation analysis in such multi-layered system. The wavenumber algorithm demonstrates a better computational performance compared to that of the traditional total focusing method (TFM) in time domain up to 6 times. The glass ply depth and waviness angle can be more accurately presented with relative errors less than 1.5% and 14.8%, respectively. In addition, the resin-rich defect characterization is also achievable with a maximum error of 14.4%.
Study on audiometer calibration at the extended high-frequency range 8–16 kHz
Authors: El-Basheer Tarek M. 
Published: October 2021

Audiometry is a branch of acoustical measurements that concentrated on testing the devices related to hearing and used in medical part such as audiometer. It is substantial to calibrate the audiometer to assure the measurement traceability and to safe human health. So, it is considered as a major claim. The importance of calibration comes from the request for advanced instrument to test accurately the hearing loss for human, especially for those people who might be at risk due to noise. The conventional audiometry covered from 125 to 8 kHz, while the extended high-frequency (EHF) audiometry above 8 up to 20 kHz, the last-mentioned type may be useful in early diagnosis of hearing loss. The audiometer calibration performed using ear simulator, standard or working microphone, sound level meter, and frequency analyzer according to IEC60645-1. The physical parameters such as sound pressure level, frequency and distortion may be affected by environmental conditions such as temperature change. The gained results observed that the measured value of all the tests performed was affected by temperature variation. There were deviations observed from each performed test’s nominal values in the calibration process as the temperature varies from 16 to 40°C. So, this is a detailed study for the significance, method, and uncertainty estimation for audiometer calibration covering the EHF ranges within the temperature from 16 to 40°C.
Clinician Perspectives on Barriers and Facilitators to Implementing e-Health Technology in Substance Use Disorder (SUD) Treatment Facilities
Authors: Fleddermann Kathryn , Molfenter Todd , Jacobson Nora , Horst Julie , Roosa Mathew R , Boss Deanne , Ross J Charles , Preuss Eric , Gustafson David H 
Published: October 2021

Background: Substance use disorders (SUDs) in the United States cause many preventable deaths each year. Finding effective ways to manage SUDs is vital to improving outcomes for individuals seeking treatment. This has increased interest in using e-health technologies in behavioral healthcare settings. This research is part of a larger study evaluating the efficacy of the NIATx coaching intervention for implementing RISE Iowa, an e-health patient recovery app, in SUD treatment organizations and seeks to examine clinician perspectives of the barriers and facilitators to its implementation. Method: Semi-structured qualitative interviews were conducted with 13 clinicians from 9 different intervention sites involved in the study. Results: Major barriers to implementing e-health technology include inability to access the technology, lack of time for both patients and clinicians, and a perceived lack of patient motivation to make changes. Facilitators to implementation include collaboration with other staff using e-health technology and integrating technology use into typical workflows. Conclusions: Implementation of e-health technology in SUD treatment will require integrating the technology into clinical workflows and improving patient access to the technology.
Outcomes of staged reconstruction of Zone 2 flexor tendon injuries in recent wide-awake surgical settings and an earlier case series
Authors: Sadek Ahmed Fathy , Hweidi Ahmed Sobhi , Ahmed Mohamed Atef 
Published: October 2021

We report outcomes of patients who were managed with two-stage tendon grafting for neglected Zone 2 flexor tendon injuries from 2012 until 2019. The patients were divided into two cohorts: recent series (Series 1) included patients treated with local anaesthesia and epinephrine (16 fingers, from 2015), and earlier series (Series 2) included patients treated with either general or local intravenous anaesthesia and tourniquet (12 fingers, before 2015). The patients in Series 1 achieved statistically better mean total active motion of the operated fingers and grip compared with the contralateral hand than the earlier series ( p = 0.03, p = 0.01, respectively). With the Tang grading system, excellent and good results were achieved in 13 and six fingers of the patients in Series 1 and Series 2, respectively. We conclude that wide-awake second stage of staged flexor tendon grafting provides fine-tuned adjustment of length and tension of the graft, but we cannot conclude about comparative outcomes between two series because the sample size is small and the earlier series was operated by the same surgeons with lower expertise level. Level of evidence: IV
Curative role of mesenchymal stromal cells in chronic pancreatitis: Modulation of MAPK and TGF-β1/SMAD factors
Authors: Taha Hager S , Moustafa Enas M , Moawed Fatma SM , Hegazy Marwa GA 
Published: October 2021

Background and objective: Living organisms respond to physical, chemical, and biological threats with a potent inflammatory response which alters organ cell signaling and leads to dysfunction. We evaluated the therapeutic effect of bone marrow-based mesenchymal stromal cell (BM-MSC) transplanted in rats to preserve tissue integrity and to restore homeostasis and function in the pancreatitis experimental pattern. Methods: This study involved 40 adult male Wister rats. Repeated L-arginine injections caused chronic pancreatitis (CP), leading to the development of pancreatic damage and shifting the intracellular signaling pathways. Rats were then infused with BM-MSC labeled with PKH26 fluorescent linker dye for 12 weeks. Results: Cell-surface indicators of BM-MSCs such as CD 90 and CD29 were expressed with the lack of CD34 expression. BM-MSC treatment considerably improved the alterations induced in a series of inflammatory markers, including IL-18, TNF-α, CRP, PGE2, and MCP-1. Furthermore, improvement was found in digestive enzymes and lipid profile with amelioration in myeloperoxidase activity. BM-MSC treatment also regulated the (TGF-/p-38MPAK/SMAD2/3) signaling factors that enhances repair of damaged pancreatic tissue, confirmed by reversed alteration of histopathological examination. Conclusion: our results further bring to light the promise of cell transplant therapy for chronic pancreatitis.
Emerging Adults and Social Distancing During COVID-19: Who Was More Likely to Follow Guidelines and What Were the Correlates With Well-Being and Weight-Related Behaviors?
Authors: Berge Jerica M. , Larson Nicole , Neumark-Sztainer Dianne 
Published: October 2021

The aim of this study is to identify the prevalence, predictors, and psychosocial well-being (depressive symptoms, stress) and weight-related behavior (eating behaviors, physical activity, and sedentary behavior) correlates of social distancing during COVID-19 among emerging adults. A rapid-response survey was sent to participants ( n=720; mean age=24.7 ± 2.0 years, 62% female) in a population-based cohort study in Minnesota during April–October 2020. Half of emerging adults reported fully social distancing. Emerging adults from White backgrounds were least likely to social distance while those from Asian backgrounds were most likely to social distance, in addition to those living with a parent. Females who partially/did not social distance reported less healthy eating behaviors, while males and “essential workers” reported higher levels of psychosocial distress. Public health messaging and practical supports for social distancing may need to be made more relevant to emerging adults during public health crises. Resources may need to differ depending on sex of emerging adult.
Blood Flow Restriction Therapy Impact on Musculoskeletal Strength and Mass
Authors: Dayton Steven R. , Padanilam Simon J. , Sylvester Tyler C. , Boctor Michael J. , Tjong Vehniah K. 
Published: October 2021

Background: Blood flow restriction (BFR) training restricts arterial inflow and venous outflow from the extremity and can produce gains in muscle strength at low loads. Low-load training reduces joint stress and decreases cardiovascular risk when compared with high-load training, thus making BFR an excellent option for many patients requiring rehabilitation. Indications: Blood flow restriction has shown clinical benefit in a variety of patient populations including healthy patients as well as those with osteoarthritis, anterior cruciate ligament reconstruction, polymyositis/dermatomyositis, and Achilles tendon rupture. Technique Description: This video demonstrates BFR training in 3 clinical areas: upper extremity resistance training, lower extremity resistance training, and low-intensity cycling. All applications of BFR first require determination of total occlusion pressure. Upper extremity training requires inflating the tourniquet to 50% of total occlusion pressure, while lower extremity exercises use 80% of total occlusion pressure. Low-load resistance training exercises follow a specific repetition scheme: 30 reps followed by a 30-second rest and then 3 sets of 15 reps with 30-seconds rest between each. During cycle training, 80% total occlusion pressure is used as the patient cycles for 15 minutes without rest. Results: Augmenting low-load resistance training with BFR increases muscle strength when compared with low-load resistance alone. In addition, low-load BFR has demonstrated an increase in muscle mass greater than low-load training alone and equivalent to high-load training absent BFR. A systematic review determined the safety of low-load training with BFR is comparable to traditional high-intensity resistance training. The most common adverse effects include exercise intolerance, discomfort, and dull pain which are also frequent in patients undergoing traditional resistance training. Severe adverse effects including deep vein thrombosis, pulmonary embolism, and rhabdomyolysis are exceedingly rare, less than 0.006% according to a national survey. Patients undergoing BFR rehabilitation experience less perceived exertion and demonstrate decreased pain scores compared with high-load resistance training. Conclusion: Blood flow restriction training is an effective alternative to high-load resistance training for patients requiring musculoskeletal rehabilitation for multiple disease processes as well as in the perioperative setting. Blood flow restriction has been shown to be a safe training modality when managed by properly trained physical therapists and athletic trainers.