bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insulin resistance limits corneal nerve regeneration in patients with type 2 diabetes undergoing intensive glycemic control
Authors: Ponirakis Georgios , Abdul‐Ghani Muhammad A , Jayyousi Amin , Zirie Mahmoud A , Al‐Mohannadi Salma , Almuhannadi Hamad , Petropoulos Ioannis N , Khan Adnan , Gad Hoda , Migahid Osama , Megahed Ayman , Qazi Murtaza , AlMarri Fatema , Al‐Khayat Fatima , Mahfoud Ziyad , DeFronzo Ralph , Malik Rayaz A 
Published: May 2021

AbstractAims/IntroductionThis study aimed to investigate whether insulin resistance (IR) in individuals with type 2 diabetes undergoing intensive glycemic control determines the extent of improvement in neuropathy.Materials and MethodsThis was an exploratory substudy of an open‐label, randomized controlled trial of individuals with poorly controlled type 2 diabetes treated with exenatide and pioglitazone or insulin to achieve a glycated hemoglobin <7.0% (<53 mmol/mol). Baseline IR was defined using homeostasis model assessment of IR, and change in neuropathy was assessed using corneal confocal microscopy.ResultsA total of 38 individuals with type 2 diabetes aged 50.2 ± 8.5 years with (n = 25, 66%) and without (n = 13, 34%) IR were studied. There was a significant decrease in glycated hemoglobin (P < 0.0001), diastolic blood pressure (P < 0.0001), total cholesterol (P < 0.01) and low‐density lipoprotein (P = 0.05), and an increase in bodyweight (P < 0.0001) with treatment. Individuals with homeostasis model assessment of IR <1.9 showed a significant increase in corneal nerve fiber density (P ≤ 0.01), length (P ≤ 0.01) and branch density (P ≤ 0.01), whereas individuals with homeostasis model assessment of IR ≥1.9 showed no change. IR was negatively associated with change in corneal nerve fiber density after adjusting for change in bodyweight (P < 0.05).ConclusionsNerve regeneration might be limited in individuals with type 2 diabetes and IR undergoing treatment with pioglitazone plus exenatide or insulin to improve glycemic control.
S2k guidelines (consensus statement) for diagnosis and therapy of dermatitis herpetiformis initiated by the European Academy of Dermatology and Venereology (EADV)
Authors: Görög A. , Antiga E. , Caproni M. , Cianchini G. , De D. , Dmochowski M. , Dolinsek J. , Drenovska K. , Feliciani C. , Hervonen K. , Lakos Jukic I. , Kinyó Á. , Koltai T. , Korponay‐Szabó I. , Marzano A.V. , Patsatsi A. , Rose C. , Salmi T. , Schmidt E. , Setterfield J. , Shahid M. , Sitaru C. , Uzun S. , Valitutti F. , Vassileva S. , Yayli S. , Sárdy M. 
Published: May 2021

AbstractIntroductionDermatitis herpetiformis (DH) is a chronic, pruritic, gluten‐induced skin disorder characterized by subepidermal granular IgA deposition and a variable degree of enteropathy identical to that seen in coeliac disease. So far, there has been no European consensus about the management of DH.MethodsThe guidelines were created by small subgroups of a guideline committee consisting of 26 specialists from various medical fields and one patients’ representative. The members of the committee then discussed the guidelines and voted for the final version at two consensus meetings. The guidelines were developed under the support of the European Academy of Dermatology and Venereology (EADV) and in collaboration with the European Dermatology Forum (EDF).ResultsThe guidelines summarize evidence‐based and expert‐based recommendations (S2 level) for the management of DH (see Appendix).ConclusionThese guidelines will improve the quality of management of DH and support dermatologists in their diagnostic and therapeutic decisions.
Establishment of the biological control agent Hypocosmiapyrochroma for Dolichandraunguis‐cati (Bignoniaceae) is limited by microclimate
Authors: Dhileepan Kunjithapatham , Snow Elizabeth L. , Shi Boyang , Gray Bradley , Jackson Kevin , Senaratne Wilmot K. A. D. 
Published: May 2021

AbstractCat's claw creeper, Dolichandra unguis‐cati (Bignoniaceae), a perennial woody vine native to tropical America, is a target for biological control in Australia and South Africa. The cat's claw creeper leaf‐tying moth Hypocosmia pyrochroma (Lepidoptera: Pyralidae) from tropical South America was released as a biological control agent for cat's claw creeper in Australia from 2007 to 2010. A total of 2,277 adults, 837 pupae and 77,250 larvae were released at 40 sites in Queensland and New South Wales. Releases were made mostly in open fields (85%), and at limited sites (15%) in insect‐proof cages erected over naturally occurring cat's claw creeper infestations in the field. Sampling was conducted annually in spring and autumn to monitor the establishment and dispersal of H. pyrochroma. Establishment of H. pyrochroma was first noticed in 2012 at three release sites and since then the number of established sites has increased to 80 in 2020. Establishment was evident on both ‘short‐pod’ and ‘long‐pod’ forms of cat's claw creeper and was more widespread in sites where releases were made within insect‐proof field cages (50%) than in sites with open field releases (9%). The moth was active from late spring to late autumn with peak larval activity in late summer. To date, all field establishments have been in areas predicted by a CLIMEX model as climatically suitable but restricted mostly to riparian environment (93% of establishment), where the moth has continued to spread from 1.5 to 23 km from release sites. In contrast, there is the only limited establishment and spread in non‐riparian corridors, highlighting the role of microclimate (riparian) as a limiting factor for establishment and spread. Future efforts will focus on redistribution of the agent to river/creek systems where the moth is currently not present.
Diversity of interpretations of the concept “patient‐centered care for breast cancer patients”; a scoping review of current literature
Authors: Pel Elise , Engelberts Ingeborg , Schermer Maartje 
Published: May 2021

AbstractRationale, aims and objectivesPatient‐centered care is considered a vital component of good quality care for breast cancer patients. Nevertheless, the implementation of this valuable concept in clinical practice appears to be difficult. The goal of this study is to bridge the gap between theoretical elaboration of “patient‐centered care” and clinical practice. To that purpose, a scoping analysis was performed of the application of the term “patient‐centered care in breast cancer treatment” in present‐day literature.MethodFor data‐extraction, a literature search was performed extracting references that were published in 2018 and included the terms “patient‐centered care” and “breast cancer”. The articles were systematically traced for answers to the following three questions: “What is patient‐centered care?”, “Why perform patient‐centered care?”, and “How to realize patient‐centered care?”. For the content analysis, these answers were coded and assembled into meaningful clusters until separate themes arose which concur with various interpretations of the term “patient‐centered care”.ResultsA total of 60 publications were retained for analysis. Traced answers to the three questions “what”, “why”, and “how” varied considerably in recent literature concerning breast cancer treatment. Despite the inconsistent use of the term “patient‐centered care,” we did not find any critical consideration about the nature of the concept, regardless of the applied interpretation. Interventions that are supposed to contribute to the heterogeneous concept of patient‐centered care as such, seem to be judged desirable, virtually without empirical justification.ConclusionsWe propose, contrary to previous efforts to define “patient‐centered care” more accurately, to embrace the heterogeneity of the concept and apply “patient‐centered care” as an umbrella‐term for all healthcare that intends to contribute to the acknowledgement of the person in the patient. For the justification of measures to realize patient‐centered care for breast cancer patients, instead of a mere contribution to the abstract concept, we insist on the demonstration of desirable real‐world effects.
Optimal frequency of individualised nutrition counselling in patients with head and neck cancer receiving radiotherapy: A systematic review
Authors: Tunzi Liana , Funk Tessa , Brown Teresa , Findlay Merran , Bauer Judith 
Published: May 2021

AbstractBackgroundHead and neck cancers (HNC) are strongly associated with malnutrition. This systematic review aimed to investigate the optimal frequency of individualised nutrition counselling (INC) pre‐, peri‐ and post‐treatment for patients with HNC.MethodsPubmed, EMBASE, Cinahl and Scopus were searched from inception through to April 2020 to identify randomised controlled trials (RCTs) that focused on the INC frequency for adult patients with HNC (Registration no. 178868). The outcomes assessed were nutritional status, dietary intake, weight change, treatment interruptions, unplanned hospital admissions, quality of life, complications and morbidity. Certainty of evidence was assessed using Grades of Recommendation, Assessment, Development and Evaluation (GRADE).ResultsFour RCTs were identified with five papers (n = 500 total participants). The certainty of evidence was ‘high’ for nutritional status and quality of life, ‘moderate’ for treatment interruptions and unplanned hospital admissions, and ‘low’ for percentage weight change, complications/morbidity and dietary intake. Compared to control groups, there were consistent improvements for nutritional status, quality of life, treatment interruptions, unplanned hospital admissions, dietary intake, percentage weight change and morbidity when weekly INC was provided peri‐treatment and fortnightly INC was provided post‐treatment. No statistical significance was found for treatment interruptions, dietary intake and weight change when INC was provided fortnightly peri‐treatment only. There were no RCTs in the current review that offered INC pre‐treatment.ConclusionsThis systematic review shows beneficial effects with weekly INC peri‐treatment and fortnightly INC post‐treatment for patients with HNC in all outcomes studied. Future research should focus on models of care to address the optimal frequency of pre‐treatment INC as well as the duration of post‐treatment INC.
Evaluation of the clinical application of the Postpartum Depression Predictors Inventory‐Revised for postpartum women in China
Authors: Zhang Liu , Li Yu‐Hong , Bu Yang‐Gao , Yang Fang‐Fang , Chen Yue‐Hua , Liao Pei‐Pei , Mu Ting‐Yu , Zhang Cheng‐Lu 
Published: May 2021

AbstractAimThis study was designed to assess the clinical applicability of the Postpartum Depression Predictors Inventory‐Revised (PDPI‐R) during the 1st month following delivery among women in China and to survey the prevalence of postpartum depression (PPD)‐related risk factors included in the PDPI‐R in this population.MethodsThis was a cross‐sectional study which recruited 447 women from the Peopleʼs Liberation Army Hospital in Hefei of Anhui province. All participants completed the Chinese version of the PDPI‐R (PDPI‐R‐C) and the Chinese version of the Edinburgh Postnatal Depression Scale (C‐EPDS) within 1 month of delivery. The predictive ability of the PDPI‐R was then evaluated through receiver operating characteristic (ROC) curve analyses.ResultsThe PDPI‐R‐C was able to accurately predict 73.2% of PPD cases (area under the ROC curve = 0.732; 95% CI 0.69–0.78) using a cut‐off score of 5.5, as defined by a C‐EPDS score of ≥10 (sensitivity = 62.8%; specificity = 73.5%; positive predictive value = 74.5%; negative predictive value = 61.5%). All 13 risk factors in the PDPI‐R‐C other than socioeconomic status and marital status were associated with the risk of PPD.ConclusionsThe PDPI‐R‐C was found to be an effective and easy‐to‐implement tool that has promise as a means of screening for PPD in Chinese populations.
The sexual wholeness model: An initial evaluation with two samples
Authors: Busby Dean M. , Hanna‐Walker Veronica R. , Leavitt Chelom E. , Carroll Jason S. 
Published: May 2021

AbstractBased upon the psychological needs delimited in self‐determination theory, we created the sexual wholeness model to encapsulate the different dimensions (physical, emotional, and meaning) that create couple sexuality. We evaluated the model with data from two national samples (Sample 1, n = 610; Sample 2, n = 884), by examining the association between sexual, relationship, and life satisfaction, and attachment with the different elements of the sexual wholeness model using harmonious sexual passion as an intermediate variable. The emotional dimension had the strongest associations in both samples with harmonious sexual passion and all other outcomes except attachment. The physical dimension of sexuality had a surprisingly strong association with attachment and sexual satisfaction. In addition, couples' self‐evaluation of the degree of sexual wholeness in their relationship was strongly associated with harmonious passion and all other outcomes, providing another level of validity to the dimensions of the model and the potential utility for using this model to assist in couple therapy.
Combined phase diagram modelling and quartz‐in‐garnet barometry of HP metapelites from the Kamieniec Metamorphic Belt (NE Bohemian Massif)
Authors: Szczepański Jacek , Zhong Xin , Dąbrowski Marcin , Wang Haozheng , Goleń Marcin 
Published: May 2021

AbstractThe Kamieniec Metamorphic Belt belongs to the Variscan Belt of Europe as the NE part of the Bohemian Massif. It comprises a supracrustal succession dominated by micaschists that has not been yet recognized as a high‐P, low‐T (HP–LT) metamorphic unit. Our work demonstrates the significance of metapelites in the study of HP metamorphism of the NE part of the Bohemian Massif. To reconstruct the P–T history of the Kamieniec Metamorphic Belt, we have investigated three samples using independent geothermobarometric techniques including phase diagram modelling, Si4+ content in white mica and quartz‐in‐garnet elastic barometry. Two samples contain mineral assemblages bearing a record of HP metamorphism followed by an LP event. The oldest assemblage is mostly preserved in the first generation of garnet and it comprises phengitic white mica and rutile. In one of the investigated samples, we also recognized chloritoid and inferred pseudomorphs after lawsonite composed of quartz, clinozoisite associated with margarite. The third of the investigated samples is strongly retrogressed and only contains the relics of phengitic white mica. All three samples contain a younger mineral assemblage comprising white mica with low Si4+ content and ilmenite. Mineral equilibria modelling indicates the P–T conditions of the HP event culminated at ~15.5–18 kbar and ~470–570℃, while the LP episode occurred at ~5–7 kbar and ~530–570℃. The Raman shift measured in quartz inclusions in garnet in samples with a well‐preserved record of the HP stage points to their entrapment at pressures between 11 and 16 kbar. The quartz inclusions within the strongly retrogressed micaschist sample exhibit Raman shifts corresponding to the LP episode at ~5–8 kbar. Discrepant results obtained for one of the samples are discussed in detail. Our investigations show that the supracrustal succession of the Kamieniec Metamorphic Belt contains a record of HP–LT metamorphism typical for subduction systems. A recently established tectonic model for the crystalline complexes exposed in the Bohemian Massif suggests that they were formed via the collision of the Saxothuringian, Teplá–Barrandian, and Brunovistulian domains. Therefore, we interpret the Kamieniec Metamorphic Belt as representing fragments of the Saxothuringian crust that experienced cold extrusion from below the Teplá–Barrandian domain in front of the rigid Brunovistulian indenter.
Late Variscan (315 Ma) subduction or deceptive zircon REE patterns and U–Pb dates from migmatite‐hosted eclogites? (Montagne Noire, France)
Authors: Pitra Pavel , Poujol Marc , Van Den Driessche Jean , Bretagne Eloïse , Lotout Caroline , Cogné Nathan 
Published: May 2021

AbstractEclogites hosted in sillimanite‐bearing migmatites in the Montagne Noire dome (French Massif Central) have an oceanic protolith and recorded a prograde P–T path from ~19.5 kbar, 700°C to the pressure peak at ~21 kbar, 750°C (pseudosection modelling), suggesting metamorphism in a subduction setting. Subsequent exhumation to low‐P high‐T (LP–HT) conditions (~6 kbar, 730°C) is constrained by the equilibration conditions of the embedding migmatite. In samples of a fresh and a retrogressed eclogite, all zircon crystals but one display similar REE patterns (no Eu anomaly, flat HREE), usually ascribed to crystallization under eclogite‐facies conditions. Yet, the U–Pb apparent ages of zircon crystals from both eclogites spread from c. 360 Ma to a dominant data cluster at c. 315 Ma. The c. 315–310 Ma zircon U–Pb dates obtained from the embedding migmatite are interpreted as the age of crystallization of the partial melt during the LP–HT metamorphic stage. First‐order geological evidence, in particular the sedimentary record, excludes the existence of a subduction zone in the region at this period. Unless calling upon a major reappraisal of the tectonics of the European Variscan orogen, this suggests an ambiguous relation between REE patterns and U–Pb dates in the zircon population. Various scenarios that could account for the observations are discussed. Combining our data with the results of a previously published Sm–Nd dating of garnet, and regional considerations, we consider that 360 Ma is the best approximation of the minimum age of the eclogite‐facies event. We hypothesize that the eclogites formed farther north and were transferred to their present location by lower‐crustal flow. It is inferred that during the subsequent exhumation, eclogite‐facies zircon grains recrystallized and underwent partial to total resetting of their U–Pb system, whereas the REE system remained mostly unmodified. These results caution against the use of REE patterns as the only criterion to associate a specific zircon age with HP metamorphism in eclogites occurring in migmatitic domes.
Efficacy of ethyl ascorbyl ether–containing cosmetic cream on blue light–induced skin changes
Authors: Jo Hong Li , Jung Yuchul , Kim Young Kyun , Kim Nahee , Cho Eunbyul , Han Jiyeon , Hwang Yoon Kyun , Suh Byung‐Fhy , Kim Eunjoo 
Published: May 2021

AbstractBackgroundOffice workers are consistently exposed to blue light, mainly from sunlight and digital device. Recent studies report that blue light has various harmful effects, including cellular changes via reactive oxygen species. Studies on blue light–induced skin changes have only been conducted in vitro and have not been clinically confirmed.ObjectiveWe provide novel methods to evaluate the effect of the product on the recovery of skin changed by blue light.MethodsInternet surveys were conducted for workers in their 20s and 40s regarding exposure time to blue light in various environments. To study the effects of long‐term exposure to blue light (456 nm) on the skin, we designed three light intensity conditions, and various skin characteristics were observed. After blue light irradiation, various skin characteristics were analyzed before and after applying ethyl ascorbyl ether (EAE)–containing cosmetic cream for 2 weeks.ResultsWhen exposed to strong blue light for approximately 16 days, the L* value, skin hydration, transparency, and elasticity decreased, and the melanin index, erythema index, a* value, and b* value increased. Furthermore, after short‐term blue light irradiation (dose, 269 J/cm2, the equivalent of blue light exposure for approximately 38 days in daily life), the L* value and elasticity decreased, and the melanin index and erythema index increased. However, when EAE cream was applied on skin for 1–2 weeks, the skin recovered.ConclusionThis study clinically confirms the skin changes caused by blue light and the effect of EAE in relieving such changes.
A comparative study of eating behaviours within and between conventional metabolic (bariatric) surgery procedures
Authors: Story Narelle Margaret , Lumby Judith , Fethney Judith , Waters Donna 
Published: May 2021

AbstractAims and ObjectivesTo compare eating behaviours within and between gastric bypass, sleeve gastrectomy and gastric band procedures and to investigate associations between eating behaviours and body weight.BackgroundEating behaviours are subjective constructs representing physiological need and the hedonic need to eat. After metabolic surgery, eating behaviours have been observed to change. Little is known about whether eating behaviour change differs according to the metabolic procedure performed.DesignAdults (n = 204) with severe obesity from three countries were followed 1 year after metabolic surgical procedures (n = 121).MethodsWe measured eating behaviours using the Three‐Factor Eating Questionnaire and used linear mixed models to compare eating behaviours within and between three procedure groups. We complied with the STROBE checklist for reporting observational studies.ResultsWithin groups, there were statistically significant increases in restraint and decreases in disinhibition and hunger. Between groups, we observed differences in disinhibition associated with the band procedure. There were no significant differences between any group for body weight or body mass index a year post‐surgery. Disinhibition was the only eating behaviour associated with body weight, body mass index and the per cent of weight loss.ConclusionsEating behaviours in adults with severe obesity who underwent any of the three metabolic procedures were associated with eating behaviour change 1 year post‐surgery. Disinhibition was the only eating behaviour that was associated with body weight.Relevance to clinical practiceIrrespective of the procedure, we found participants had a statistically significant increase in restraint and decreases in disinhibition and hunger 1 year post‐surgery. Despite the significant reduction in disinhibition within the band group, this behaviour was more pronounced post‐surgery compared with other groups. Although the reduction in hunger showed the greatest change, it was not associated with weight outcomes. This is relevant clinical knowledge for nurses who support bariatric surgical patients.