bluuebunny/crossref_metadata_2025_split huggingface dataset:
A geometrically nonlinear shear deformable beam model for piezoelectric energy harvesters
Authors: Shang Lan , Hoareau Christophe , Zilian Andreas 
Published: November 2021

AbstractAn electromechanical model for beam-like piezoelectric energy harvesters based on Reissner’s beam theory is developed in this paper. The proposed model captures first-order shear deformation and large displacement/rotation, which distinguishes this model from other models reported in the literature. All governing equations are presented in detail, making the associated framework extensible to investigate various piezoelectric energy harvesters. The weak formulation is then derived to obtain the approximate solution to the governing equations by the finite element method. This solution scheme is completely coupled, and thus allows for two-way interaction between mechanical and electrical fields. To validate this model, extensive numerical examples are implemented in the linear and nonlinear regime. In the linear limit, this model produces results in excellent agreement with reference data. In the nonlinear regime, the large amplitude response of the piezoelectric beam induced by strong base excitation or fluid flow is considered, and the comparison of results with literature data is encouraging. The ability of this nonlinear model to predict limit cycle oscillations in axial flow is demonstrated.
Pretreatment clinical and hematologic prognostic factors of metastatic urothelial carcinoma treated with pembrolizumab: a systematic review and meta-analysis
Authors: Yanagisawa Takafumi , Mori Keiichiro , Katayama Satoshi , Mostafaei Hadi , Quhal Fahad , Laukhtina Ekaterina , Rajwa Pawel , Motlagh Reza Sari , Aydh Abdulmajeed , König Frederik , Grossmann Nico C. , Pradere Benjamin , Miki Jun , Kimura Takahiro , Egawa Shin , Shariat Shahrokh F. 
Published: November 2021

AbstractPembrolizumab is the standard for the first and second lines in treating metastatic urothelial carcinoma (UC). This systematic review and meta-analysis aimed to assess the value of pretreatment clinical characteristics and hematologic biomarkers for prognosticating response to pembrolizumab in patients with metastatic UC. PUBMED®, Web of Science™, and Scopus® databases were searched for articles published before May 2021 according to the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) statement. Studies were deemed eligible if they evaluated overall survival (OS) in patients with metastatic urothelial carcinoma treated with pembrolizumab and pretreatment clinical characteristics or laboratory examination. Overall, 13 studies comprising 1311 patients were eligible for the meta-analysis. Several pretreatment patients’ demographics and hematologic biomarkers were significantly associated with worse OS as follows: Eastern Cooperative Oncology Group Performance Status (ECOG-PS) ≥ 2 (Pooled hazard ratio [HR]: 3.24, 95% confidence interval [CI] 2.57–4.09), presence of visceral metastasis (Pooled HR: 1.84, 95% CI 1.42–2.38), presence of liver metastasis (Pooled HR: 4.23, 95% CI 2.18–8.20), higher neutrophil–lymphocyte ratio (NLR) (Pooled HR: 1.29, 95% CI 1.07–1.55) and, higher c-reactive protein (CRP) (Pooled HR: 2.49, 95% CI 1.52–4.07). Metastatic UC patients with poor PS, liver metastasis, higher pretreatment NLR and/or CRP have a worse survival despite pembrolizumab treatment. These findings might help to guide the prognostic tools for clinical decision-making; however, they should be interpreted carefully, owing to limitations regarding the retrospective nature of primary data.
Evaluation of a Mobile Web Application for Assessment Feedback
Authors: Bikanga Ada Mireilla 
Published: November 2021

AbstractThis paper reports an evaluation of a mobile web application, “MyFeedBack”, that can deliver both feedback and marks on assignments to students from their lecturer. It enables them to use any device anywhere, any time to check on, and receive their feedback. It keeps the feedback private to the individual student. It enables and successfully fosters dialogue about the feedback between the students and the educator. Feedback and marks were already being delivered using the institution’s learning environment/management system “Moodle”. The study used a sequential explanatory mixed-method approach. Two hundred thirty-nine (239) participants were reported on their experiences of receiving feedback and divided among several groups: (a) feedback delivered in “Moodle”, (b) formative feedback in “MyFeedBack”, and (c) summative feedback in “MyFeedBack”. Overall, results showed a statistically significant more positive attitude towards “MyFeedBack” than “Moodle”, with the summative assessment subgroup being more positive than the formative subgroup. There was an unprecedented increase in communication and feedback dialogue between the lecturer and the students. Qualitative results enriched and complemented the findings. The paper provides guidelines for an enabling technology for assessment feedback. These offer insight into the extent to which any of the new apps and functionalities that have become available since this study might likely be favourably viewed by learners and help achieve the desired pedagogical outcomes. These include: (1) accessible using any device, making feedback accessible anywhere, anytime; (2) display feedback first (before the grade/mark); (3) enable personalisation of group feedback by the teacher; (4) provide privacy for each student; (5) facilitate dialogue and communication about the feedback; and (6) include a monitoring feature. Three goals already put forward in the literature—(1) making the feedback feel more personal, (2) getting a quicker turnround by making it easier for the teachers to achieve this, and (3) prompting more dialogue between the educators and students—are advanced by this study which shows how they can be supported by software, and that when they are achieved then users strongly approve them.
Acetosolv pretreatment of wood for biorefinery applications
Authors: Marks Caroline , Viell Jörn 
Published: November 2021

AbstractThe production of biofuels and biochemicals requires a pretreatment to cleave the composite-like structure of lignocellulosic biomass and thus facilitate further conversion. In the case of liquid-based pretreatment, it is important to know which pretreatment liquids allow for an effective conversion of biomass. For the development of effective pretreatment strategies, simple criteria for a fast evaluation of pretreatment results are advantageous. In this study, we use the example of acetosolv pretreatment of beech wood to explore the influence of composition of the employed acetosolv liquids. To this end, we investigate pretreatment phenomena on different scales including macroscopic disintegration, overall mass balances and compositional changes of beech wood. We relate the investigated phenomena with the type and amount of catalyst acid as well as water content of the employed acetosolv liquids. The results show that disintegration increases with both a higher concentration and acidity of the catalyst acid, while excessive disintegration can be balanced by an increased water content up to equimolar ratios of water and acetic acid. Furthermore, an increasing disintegration correlates with an increasing non-recovered fraction up to a maximum of 40 wt%. The non-recovered fraction in turn linearly depends on the amount of removed hemicellulose and lignin. Overall, a low lignin content together with complete disintegration after pretreatment in acetosolv liquids with a high water content allows for increased sugar yields in subsequent enzymatic hydrolysis. Thus, disintegration and non-recovered fraction serve as a simple indicator for a first assessment of pretreatment effectiveness.
Documentary heritage in the Arab region: a regional survey
Authors: Harfouche Anissa 
Published: November 2021

AbstractIn 2018, the UNESCO Office to the Gulf States and Yemen and its partner, Qatar National Library, launched a project aiming at supporting the preservation of documentary heritage in the Arab region. The Arab region is home to a unique and rich documentary heritage subject to risk due to natural decay, conflicts and instability. To support its preservation, this project had for objective to better understand the needs and challenges faced by documentary heritage institutions in the region though a mapping exercise and the dissemination of a survey.This article outlines the key outcomes of the survey including the situation of documentary heritage at the regional and national level, a brief review of legal frameworks protecting documentary heritage, the main obstacles and threats to documentary heritage preservation and the needs expressed by conservation practitioners in terms of capacity-building, professional development, infrastructure and support in additional areas such as policy and advocacy.
Decision-theoretic inspection planning using imperfect and incomplete data
Authors: Di Francesco Domenic , Chryssanthopoulos Marios , Faber Michael Havbro , Bharadwaj Ujjwal 
Published: November 2021

AbstractAttempts to formalize inspection and monitoring strategies in industry have struggled to combine evidence from multiple sources (including subject matter expertise) in a mathematically coherent way. The perceived requirement for large amounts of data are often cited as the reason that quantitative risk-based inspection is incompatible with the sparse and imperfect information that is typically available to structural integrity engineers. Current industrial guidance is also limited in its methods of distinguishing quality of inspections, as this is typically based on simplified (qualitative) heuristics. In this paper, Bayesian multi-level (partial pooling) models are proposed as a flexible and transparent method of combining imperfect and incomplete information, to support decision-making regarding the integrity management of in-service structures. This work builds on the established theoretical framework for computing the expected value of information, by allowing for partial pooling between inspection measurements (or groups of measurements). This method is demonstrated for a simulated example of a structure with active corrosion in multiple locations, which acknowledges that the data will be associated with some precision, bias, and reliability. Quantifying the extent to which an inspection of one location can reduce uncertainty in damage models at remote locations has been shown to influence many aspects of the expected value of an inspection. These results are considered in the context of the current challenges in risk based structural integrity management.
A 360-Day Administrative Year in Ancient Israel: Judahite Portable Calendars and the Flood Account
Authors: Ben-Dov Jonathan 
Published: November 2021

AbstractAdministrators in ancient Judah used schematic 30-day months and a 360-day year alongside other annual frameworks. This year was never practiced as a “calendar” for any cultic or administrative purpose, but rather served as a convenient framework for long-term planning, as well as for literary accounts that were not anchored to a concrete calendar year. Examples for such a usage are attested here from Mesopotamian texts. Material evidence for the 360-day year in Judah comes forth from a series of small perforated bone plaques from various sites in Iron Age Judah. One such item was recently unearthed in the city of David. These objects can reasonably be understood as reflecting a schematic 360-day year, serving as desk calendars for Judahite administrators. Several priestly pentateuchal texts are best understood against this background, such as the dating of some festivals and most notably the dates in the Flood narrative (Gen 7–8). The original dating system is best represented in LXX Gen 7:11, while the reading of MT is a late modification, inserted later, when calendar debates took a central place in the religious discourse. MT is thus a link in a chain of later reworking of this narrative in Second Temple literature. The 360-day year is thus a unique case where material culture dovetails with literary evidence, and may shed light on the material culture of priestly sources. This insight is significant for future studies of biblical time reckoning.
The Anti-Bureaucratic Ghost in China's Bureaucratic Machine
Authors: Ding Iza , Thompson-Brusstar Michael 
Published: November 2021

AbstractThe Chinese Communist Party's (CCP) ideology, rooted in its foundational struggles, explicitly denounces “bureaucratism” (guanliaozhuyi) as an intrinsic ailment of bureaucracy. Yet while the revolutionary Party has blasted bureaucratism, its revolutionary regime has had to find a way to coexist with bureaucracy, which is a requisite for effective governance. An anti-bureaucratic ghost thus dwells in the machinery of China's bureaucratic state. We analyse the CCP's anti-bureaucratism through two steps. First, we perform a historical analysis of the Party's anti-bureaucratic ideology, teasing out its substance and emphasizing its roots in and departures from European Marxism and Leninism. Second, we trace both the continuity and evolution in the Party's anti-bureaucratic rhetoric, taking an interactive approach that combines close reading with computational analysis of the entire corpus of thePeople's Daily(1947–2020). We find striking endurance as well as subtle shifts in the substance of the CCP's anti-bureaucratic ideology. We show that bureaucratism is an umbrella term that expresses the revolutionary Party's anxiety about losing its popular legitimacy. Yet the substance of the Party's concern evolved from commandism and revisionism under Mao, to corruption and formalism during reform. The Party's ongoing critiques of bureaucratism and formalism unfold in parallel fashion with its efforts to standardize, regularize and institutionalize the state.
Predicting CEFR levels in learners of English: The use of microsystem criterial features in a machine learning approach
Authors: Gaillat Thomas , Simpkin Andrew , Ballier Nicolas , Stearns Bernardo , Sousa Annanda , Bouyé Manon , Zarrouk Manel 
Published: November 2021

AbstractThis paper focuses on automatically assessing language proficiency levels according to linguistic complexity in learner English. We implement a supervised learning approach as part of an automatic essay scoring system. The objective is to uncover Common European Framework of Reference for Languages (CEFR) criterial features in writings by learners of English as a foreign language. Our method relies on the concept of microsystems with features related to learner-specific linguistic systems in which several forms operate paradigmatically. Results on internal data show that different microsystems help classify writings from A1 to C2 levels (82% balanced accuracy). Overall results on external data show that a combination of lexical, syntactic, cohesive and accuracy features yields the most efficient classification across several corpora (59.2% balanced accuracy).
THE TOM DIECK SPLITTING THEOREM IN EQUIVARIANT MOTIVIC HOMOTOPY THEORY
Authors: Gepner David , Heller Jeremiah 
Published: November 2021

AbstractWe establish, in the setting of equivariant motivic homotopy theory for a finite group, a version of tom Dieck’s splitting theorem for the fixed points of a suspension spectrum. Along the way we establish structural results and constructions for equivariant motivic homotopy theory of independent interest. This includes geometric fixed-point functors and the motivic Adams isomorphism.
Sequential Landfall of Tropical Cyclones in the United States: From Historical Records to Climate Projections
Authors: Xi Dazhi , Lin Ning 
Published: November 2021

AbstractIn this study, we examine sequential landfalling tropical cyclones (TCs) along U.S. East and Gulf Coasts. We find that Florida and Louisiana are most prone to sequential landfall risk. The minimal time between sequential landfalling TC has decreased for most regions since 1979, although the trend is not statistically significant given limited data. A climate projection indicates a significant increase in sequential landfalls over the 21st century under the SSP5 8.5 scenario, with the chance of a location experiencing a less‐than‐10‐day break between two TC impacts being doubled for most regions. The increases in sequential landfalls in the historical period and projected future climate are both related to increased landfall frequency, even though the storm season has been slightly expanding and may continue to expand. This study highlights a new type of TC hazard resulting from the temporal compounding of landfalls and urges the improvement of coastal resilience.
Adverse clinical outcomes in people at clinical high-risk for psychosis related to altered interactions between hippocampal activity and glutamatergic function
Authors: Allen Paul , Hird Emily J. , Orlov Natasza , Modinos Gemma , Bossong Matthijs , Antoniades Mathilde , Sampson Carly , Azis Matilda , Howes Oliver , Stone James , Perez Jesus , Broome Matthew , Grace Anthony A. , McGuire Philip 
Published: November 2021

AbstractPreclinical rodent models suggest that psychosis involves alterations in the activity and glutamatergic function in the hippocampus, driving dopamine activity through projections to the striatum. The extent to which this model applies to the onset of psychosis in clinical subjects is unclear. We assessed whether interactions between hippocampal glutamatergic function and activity/striatal connectivity are associated with adverse clinical outcomes in people at clinical high-risk (CHR) for psychosis. We measured functional Magnetic Resonance Imaging of hippocampal activation/connectivity, and 1H-Magnetic Resonance Spectroscopy of hippocampal glutamatergic metabolites in 75 CHR participants and 31 healthy volunteers. At follow-up, 12 CHR participants had transitioned to psychosis and 63 had not. Within the clinical high-risk cohort, at follow-up, 35 and 17 participants had a poor or a good functional outcome, respectively. The onset of psychosis (ppeakFWE = 0.003, t = 4.4, z = 4.19) and a poor functional outcome (ppeakFWE < 0.001, t = 5.52, z = 4.81 and ppeakFWE < 0.001, t = 5.25, z = 4.62) were associated with a negative correlation between the hippocampal activation and hippocampal Glx concentration at baseline. In addition, there was a negative association between hippocampal Glx concentration and hippocampo-striatal connectivity (ppeakFWE = 0.016, t = 3.73, z = 3.39, ppeakFWE = 0.014, t = 3.78, z = 3.42, ppeakFWE = 0.011, t = 4.45, z = 3.91, ppeakFWE = 0.003, t = 4.92, z = 4.23) in the total CHR sample, not seen in healthy volunteers. As predicted by preclinical models, adverse clinical outcomes in people at risk for psychosis are associated with altered interactions between hippocampal activity and glutamatergic function.
Rapid oxygen exchange between hematite and water vapor
Authors: Jakub Zdenek , Meier Matthias , Kraushofer Florian , Balajka Jan , Pavelec Jiri , Schmid Michael , Franchini Cesare , Diebold Ulrike , Parkinson Gareth S. 
Published: November 2021

AbstractOxygen exchange at oxide/liquid and oxide/gas interfaces is important in technology and environmental studies, as it is closely linked to both catalytic activity and material degradation. The atomic-scale details are mostly unknown, however, and are often ascribed to poorly defined defects in the crystal lattice. Here we show that even thermodynamically stable, well-ordered surfaces can be surprisingly reactive. Specifically, we show that all the 3-fold coordinated lattice oxygen atoms on a defect-free single-crystalline “r-cut” ($$1\bar{1}02$$
1

1

¯

02
) surface of hematite (α-Fe2O3) are exchanged with oxygen from surrounding water vapor within minutes at temperatures below 70 °C, while the atomic-scale surface structure is unperturbed by the process. A similar behavior is observed after liquid-water exposure, but the experimental data clearly show most of the exchange happens during desorption of the final monolayer, not during immersion. Density functional theory computations show that the exchange can happen during on-surface diffusion, where the cost of the lattice oxygen extraction is compensated by the stability of an HO-HOH-OH complex. Such insights into lattice oxygen stability are highly relevant for many research fields ranging from catalysis and hydrogen production to geochemistry and paleoclimatology.
2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
Authors: Nakashima Yu , Brewitz Lennart , Tumber Anthony , Salah Eidarus , Schofield Christopher J. 
Published: November 2021

Abstract2-Oxoglutarate (2OG) oxygenases are validated agrochemical and human drug targets. The potential for modulating their activity with 2OG derivatives has not been explored, possibly due to concerns regarding selectivity. We report proof-of-principle studies demonstrating selective enhancement or inhibition of 2OG oxygenase activity by 2-oxo acids. The human 2OG oxygenases studied, factor inhibiting hypoxia-inducible transcription factor HIF-α (FIH) and aspartate/asparagine-β-hydroxylase (AspH), catalyze C3 hydroxylations of Asp/Asn-residues. Of 35 tested 2OG derivatives, 10 enhance and 17 inhibit FIH activity. Comparison with results for AspH reveals that 2OG derivatives selectively enhance or inhibit FIH or AspH. Comparison of FIH structures complexed with 2OG derivatives to those for AspH provides insight into the basis of the observed selectivity. 2-Oxo acid derivatives have potential as drugs, for use in biomimetic catalysis, and in functional studies. The results suggest that the in vivo activity of 2OG oxygenases may be regulated by natural 2-oxo acids other than 2OG.
Scaffolding protein CcmM directs multiprotein phase separation in β-carboxysome biogenesis
Authors: Zang Kun , Wang Huping , Hartl F. Ulrich , Hayer-Hartl Manajit 
Published: November 2021

AbstractCarboxysomes in cyanobacteria enclose the enzymes Rubisco and carbonic anhydrase to optimize photosynthetic carbon fixation. Understanding carboxysome assembly has implications in agricultural biotechnology. Here we analyzed the role of the scaffolding protein CcmM of the β-cyanobacterium Synechococcus elongatus PCC 7942 in sequestrating the hexadecameric Rubisco and the tetrameric carbonic anhydrase, CcaA. We find that the trimeric CcmM, consisting of γCAL oligomerization domains and linked small subunit-like (SSUL) modules, plays a central role in mediation of pre-carboxysome condensate formation through multivalent, cooperative interactions. The γCAL domains interact with the C-terminal tails of the CcaA subunits and additionally mediate a head-to-head association of CcmM trimers. Interestingly, SSUL modules, besides their known function in recruiting Rubisco, also participate in intermolecular interactions with the γCAL domains, providing further valency for network formation. Our findings reveal the mechanism by which CcmM functions as a central organizer of the pre-carboxysome multiprotein matrix, concentrating the core components Rubisco and CcaA before β-carboxysome shell formation.
Slow acoustic surface modes through the use of hidden geometry
Authors: Shelley S. R. , Beadle J. G. , Hibbins A. P. , Sambles J. R. 
Published: November 2021

AbstractThe acoustic surface modes supported by a partly covered periodic meander groove structure formed in an assumed perfectly rigid plate are investigated. This allows one to create a slower acoustic surface wave than can be achieved with the same uncovered meander structure. By changing the size of the uncovered section the phase and group speeds can be tuned. When the uncovered section of the meander structure is centred along the grooves then the distance along the grooves between neighbouring holes is the same on both sides of the structure so no band gap is observed at the first Brillouin zone boundary due to glide symmetry. This then gives quite linear dispersion. As the uncovered section’s position is moved away from the centre of the meander structure a band gap opens at the Brillouin zone boundary.