bluuebunny/crossref_metadata_2025_split huggingface dataset:
Staged radiosurgery alone versus postoperative cavity radiosurgery for patients with midsize-to-large brain metastases: a propensity score matching analysis
Authors: Yomo Shoji , Yako Takehiro , Kitazawa Kazuo , Oguchi Kazuhiro 
Published: December 2021

OBJECTIVE
The authors investigated and compared the results of staged stereotactic radiosurgery (S-SRS) alone and those of postoperative cavity SRS (C-SRS) for patients with midsize-to-large brain metastases (BMs).

METHODS
Patients with BMs who had undergone S-SRS or C-SRS during the period from 2010 to 2020 were retrospectively identified from an institutional database. The two treatment groups were generated by propensity score matching (PSM; match ratio 2:1) based on 13 potential prognostic covariates: sex, age, Karnofsky Performance Status, type of primary cancer, timing of BM diagnosis, extracranial disease status, driver mutations, molecular target therapy, neurological symptoms, number of BMs, location of BMs treated with S-SRS or C-SRS, maximal tumor or cavity volume, and cumulative intracranial tumor volume. Patient survival and control of intracranial disease were compared between the S-SRS and C-SRS groups using time-dependent analyses taking into account competing events.

RESULTS
In total, 110 patients in the S-SRS group and 62 in the C-SRS group were selected by PSM. In the S-SRS group, the median interval between the two radiosurgical sessions was 21 days, and the median total prescription dose was 28 Gy at 50%. In the C-SRS group, the median time from surgery to C-SRS was 16 days, and the median prescription dose delivered to the surgical cavity was 15 Gy at 55%. At the time point of data set fixation, 129 patients had died, 43 were alive, and none had been lost to follow-up. The 2-year survival rates for the S-SRS and C-SRS groups after the initial intervention were 33% and 37% and the median survival times were 14.8 and 17.5 months, respectively (p = 0.33). The 2-year cumulative neurological mortality rates were 11% and 9%, respectively (p = 0.65). The 2-year local failure rates were 32% and 12% (p = 0.036) and the 2-year distant recurrence rates were 55% and 58%, respectively (p = 0.53). The 2-year leptomeningeal disease development rates were 9% and 25%, respectively (p = 0.007).

CONCLUSIONS
The present study revealed no significant difference in overall survival or cumulative neurological mortality between the S-SRS and C-SRS groups. The local control failure rate was significantly higher in the S-SRS group, whereas the incidence of leptomeningeal disease development was significantly higher in the C-SRS group.
Is L5/S1 interbody fusion necessary in long-segment surgery for adult degenerative scoliosis? A systematic review and meta-analysis
Authors: Cavagnaro María José , Orenday-Barraza José Manuel , Khan Naushaba , Kisana Haroon , Avila Mauricio J. , Dowell Aaron , Strouse Isabel Martha , Ravinsky Robert , Baaj Ali A. 
Published: December 2021

OBJECTIVE
There is no consensus regarding the best surgical strategy at the lumbosacral junction (LSJ) in long constructs for adult spinal deformity (ASD). The use of interbody fusion (IF) has been advocated to increase fusion rates, with additional pelvic fixation (PF) typically recommended. The actual benefit of IF even when extending to the pelvis, however, has not been vigorously analyzed. The goal of this work was to better understand the role of IF, specifically with respect to arthrodesis, when extending long constructs to the ilium.

METHODS
A systematic review of the PubMed and Cochrane databases was performed to identify the relevant studies in English, addressing the management of LSJ in long constructs (defined as ≥ 5 levels) in ASD. The search terms used were as follows: “Lumbosacral Junction,” “Long Constructs,” “Long Fusion to the Sacrum,” “Sacropelvic Fixation,” “Interbody Fusion,” and “Iliac Screw.” The authors excluded technical notes, case reports, literature reviews, and cadaveric studies; pediatric populations; pathologies different from ASD; studies not using conventional techniques; and studies focused only on alignment of different levels.

RESULTS
The PRISMA protocol was used. The authors found 12 retrospective clinical studies with a total of 1216 patients who were sorted into 3 different categories: group 1, using PF or not (n = 6); group 2, using PF with or without IF (n = 5); and group 3, from 1 study comparing anterior lumbar interbody fusion versus transforaminal lumbar interbody fusion. Five studies in group 1 and 4 in group 2 had pseudarthrosis rate as primary outcome and were selected for a quantitative analysis. Forest plots were used to display the risk ratio, and funnel plots were used to look at the risk of publication bias. The summary risk ratios were 0.36 (0.23–0.57, p < 0.001) and 1.03 (0.54–1.96, p = 0.94) for the PF and IF, respectively; there is a protective effect of overall pseudarthrosis for using PF in long constructs for ASD surgeries, but not for using IF.

CONCLUSIONS
The long-held contention that L5/S1 IF is always advantageous in long-construct deformity surgery is not supported by the current literature. Based on the findings from this systematic review and meta-analysis, PF with or without additional L5/S1 interbody grafting demonstrates similar overall construct pseudarthrosis rates. The added risk and costs associated with IF, therefore, should be more closely considered on a case-by-case basis.
Master’s Photo Art Project ‘Ethnic Language of the Sacred’
Authors: Bezruchko Oleksandr , Bardyn Volodymyr 
Published: December 2021

The author’s idea of this master’s photographic art project was to create a series of photographs that should draw attention to the current state of the sacred heritage of Boykivshchyna with the aim of their future preservation.
The series of works consists of photographs that convey archaic architecture, a special style of icon painting, church objects, carvings and interior paintings that are typical of the Boyko ethnos.
The effect of rose hip on experimental anti-GBM glomerulonephritis in systemic lupus erythematosus murine models
Authors: Martirosyan Danik , Min So-Youn , Xie Chun , Yan Mei , Bashmakov Anna , Williams Samantha , Mohan Chandra 
Published: December 2021

Background: Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease with ominous end organ manifestations significantly affecting the kidneys and joints. One of the most frequent manifestations is glomerulonephritis (GN), a renal disease distinguished by inflammation of the glomeruli that often leads to end stage kidney failure. Treatments often have severe side effects. Rose hip (RH) is derived from Rosa canina L. and has been used as a medicinal plant for centuries; it contains numerous beneficial constituents, and has the capacity to counter lipid peroxidation, oxidative stress, and inflammation. Methods: Nephritis was induced in 129/svJ strain mice using anti-glomerular basement membrane antibodies (anti-GBM). The experimental group was fed whole RH preparation (100mg/kg body weight per day) by oral gavage from D5 to D10; the control group was fed the diluent used to dissolve RH (10 mice per group). Mice were sacrificed on D11 and phenotyped for disease. Blood urea nitrogen (BUN) and proteinuria were measured; flow cytometry of kidneys was performed on both groups. Results: RH treatment decreased proteinuria, blood urea nitrogen, CD4+, CD8+, CD11b+Gr-1+ (neutrophil), and CD11b+CD11c+ (myeloid cells) compared with nephritis control. The presence of vitamin C was confirmed. RH largely maintained its total antioxidant capacity and some vitamin C content for 24 hours, as well as at least 7 days after preparation. Conclusion: Our preliminary results confirmed that RH has antioxidative properties, significant anti-inflammatory effects, and may be useful in managing glomerulonephritisKeywords: Rose hip, glomerulonephritis, systemic lupus erythematosus, lupus, proteinuria, blood urea nitrogen, CD4+, CD8+, CD11b+Gr-1+(neutrophil), and CD11b+CD11c+ (myeloid cells)
Total Cholesterol and APOE-Related Risk for Alzheimer’s Disease in the Alzheimer’s Disease Neuroimaging Initiative
Authors: Dunk Michelle M. , Driscoll Ira ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: December 2021

Background: APOE ɛ4 allele confers greatest genetic risk for Alzheimer’s disease (AD), yet mechanisms underlying this risk remain elusive. APOE is involved in lipid metabolism, and literature suggest relationships between high total cholesterol, APOE, and AD. Further investigation is needed to elucidate the potential role of total cholesterol in AD risk. Objective: To investigate the relationship between total cholesterol and APOE-related AD risk in the Alzheimer’s Disease Neuroimaging Initiative. Methods: Participants ( N = 1,534) were classified as controls (cognitively normal; N = 404), early mild cognitive impairment (MCI; N = 294), late MCI ( N = 539), or AD ( N = 297). Total cholesterol levels were compared across APOE genotype and diagnosis. Mendelian randomization was performed to examine causality between total cholesterol and AD risk using APOE as a genetic instrument. Results: Total cholesterol was higher in APOE4+ compared to APOE3 and APOE2+ ( ps < 0.04) carriers. Those with AD and late MCI ( ps < 0.001) had higher total cholesterol than the control group. Comparing APOE4+ to APOE3 carriers, the predicted odds ratios per mg/dL greater total cholesterol were 1.11 for MCI (95% confidence interval, 1.04–7.32), 1.05 for early MCI (1.01–3.22), 1.13 for late MCI (1.05–11.70), 1.21 for AD (1.09–54.05), and 1.13 for composite dementia (MCI or AD; 1.06–11.59) ( ps < 0.05, F-statistics > 10). Conclusion: Higher total cholesterol may be a significant contributor to AD risk, particularly in APOE4 carriers who, based on existing literature, tend to have impaired cholesterol metabolism. Our findings highlight a possible mechanism by which APOE confers AD risk and indicate potential for AD risk modification through maintenance of healthy total cholesterol levels.
Isoform-Dependent Effects of Apolipoprotein E on Sphingolipid Metabolism in Neural Cells
Authors: Kurano Makoto , Tsukamoto Kazuhisa , Sakai Eri , Hara Masumi , Yatomi Yutaka 
Published: December 2021

Background: Sphingosine 1-phosphate (S1P) and ceramides have been implicated in the development of Alzheimer’s disease. Apolipoprotein E (ApoE) isoforms are also involved in the development of Alzheimer’s disease. Objective: We aimed at elucidating the potential association of the ApoE isoforms with sphingolipid metabolism in the central nervous system. Methods: We investigated the modulations of apolipoprotein M (apoM), a carrier of S1P, S1P, and ceramides in Apoeshl mice, which spontaneously lack apoE, and U251 cells and SH-SY5Y cells infected with adenovirus vectors encoding for apoE2, apoE3, and apoE4. Results: In the brains of Apoeshl mice, the levels of apoM were lower, while those of ceramides were higher. In U251 cells, cellular apoM and S1P levels were the highest in the cells overexpressing apoE2 among the apoE isoforms. The cellular and medium contents of ceramides decreased in the order of the cells overexpressing apoE3 > apoE2 and increased in the cells overexpressing apoE4. In SH-SY5Y cells, apoM mRNA and medium S1P levels were also the highest in the cells overexpressing apoE2. The cellular contents of ceramides decreased in the order of the cells overexpressing apoE3 > apoE2 = apoE4 and those in medium decreased in the order of the cells overexpressing apoE3 > apoE2, while increased in the cells overexpressing apoE4. Conclusion: The modulation of apoM and S1P might partly explain the protective effects of apoE2 against Alzheimer’s disease, and the modulation of ceramides might be one of the mechanisms explaining the association of apoE4 with the development of Alzheimer’s disease.
Exploration of the Mechanism Underlying the Association of Incident Microinfarct and Motor Deficit: A Preliminary Functional MRI Study
Authors: Luo Xiao , Hong Hui , Wang Shuyue , Li Kaicheng , Zeng Qingze , Hong Luwei , Liu Xiaocao , Li Zheyu , Fu Yanv , Jiaerken Yeerfan , Xu XiaoPei , Yu Xinfeng , Huang Peiyu , Zhang Minming 
Published: December 2021

Background: Cerebral microinfarcts (CMIs) might cause measurable disruption to brain connections and are associated with cognitive decline, but the association between CMIs and motor impairment is still unclear. Objective: To assess the CMIs effect on motor function in vivo and explore the potential neuropathological mechanism based on graph-based network method. Methods: We identified 133 non-demented middle-aged and elderly participants who underwent MRI scanning, cognitive, and motor assessment. The short physical performance battery (SPPB) assessed motor function, including balance, walking speed, and chair stand. We grouped participants into 34 incident CMIs carriers and 99 non-CMIs carriers as controls, depending on diffusion-weighted imaging. Then we assessed the independent CMIs effects on motor function and explored neural mechanisms of CMIs on motor impairment via mapping of degree centrality (DC) and eigenvector centrality (EC). Results: CMIs carriers had worse motor function than non-carriers. Linear regression analyses showed that CMIs independently contributed to motor function. CMIs carriers had decreased EC in the precuneus, while increased DC and EC in the middle temporal gyrus and increased DC in the inferior frontal gyrus compared to controls ( p < 0.05, corrected). Correlation analyses showed that EC of precuneus was related to SPPB (r = 0.25) and balance (r = 0.27); however, DC (r = –0.25) and EC (r = –0.25) of middle temporal gyrus was related with SPPB in all participants ( p < 0.05, corrected). Conclusion: CMIs represent an independent risk factor for motor dysfunction. The relationship between CMIs and motor function may be attributed to suppression of functional hub region and compensatory activation of motor-related regions.
Age of Symptom Onset and Longitudinal Course of Sporadic Alzheimer’s Disease, Frontotemporal Dementia, and Vascular Dementia: A Systematic Review and Meta-Analysis
Authors: Day Sally , Roberts Stefanie , Launder Nathalie H. , Goh Anita M.Y. , Draper Brian , Bahar-Fuchs Alex , Loi Samantha M. , Laver Kate , Withall Adrienne , Cations Monica 
Published: December 2021

Background: Understanding how the age of dementia symptom onset affects the longitudinal course of dementia can assist with prognosis and care planning. Objective: To synthesize evidence regarding the relationship of age of symptom onset with the longitudinal course of sporadic Alzheimer’s disease (AD), vascular dementia (VaD), and frontotemporal dementia (FTD). Methods: We searched Medline, CINAHL, Embase, PsycINFO, PubMed, and Scopus for longitudinal studies that examined the impact of sporadic AD, VaD, or FTD symptom onset age on measures of cognition, function, or behavioral symptoms. Studies that examined age at diagnosis only were excluded. Quantitative meta-analysis was conducted where studies reported sufficient data for pooling. Results: Thirty studies met all inclusion criteria (people with AD ( n = 26), FTD ( n = 4)) though no studies examined VaD. Earlier onset of AD was associated with more rapid annual cognitive decline (estimate = –0.07; 95% CI –0.14 to 0.00; p = 0.045). Most studies that stratified their sample reported that younger AD onset (usually < 65 years) was associated with more rapid cognitive decline. Other evidence was inconclusive. Conclusion: Younger people with AD appear to have a poorer prognosis in terms of faster cognitive decline than older people with AD. More research is required to determine the impact of symptom onset age in VaD and FTD, and on functional decline in all dementias.
ANALISIS PEMBENTUKAN LARVA AEDES AEGYPTISp TERHADAP TEMEPHOS DEMAM BERDARAH DENGUE
Authors: Stientje Stientje , Yusuf Andi , Ganesa Jalil 
Published: December 2021

Pembentukan larva dari telur berubah menjadi pupa sampai menghasilkan nyamuk Aedes aeypti sebagai vektor penyakit diantaranya Demam Berdarah Dengue (DBD). Demam berdarah dengue (DBD) merupakan penyakit yang diakibatkan oleh virus dengue yang ditularkan melalui gigitan vektor nyamuk Aedes aegypti yang bisa menyebar secara cepat. Dalam pengendalian vektor demam berdarah dengue (DBD) diperlukan dukungan atau partisipasi warga dalam menurunkan kasus demam berdarah diwilayah Kelurahan Turikale Kecamatan Turikale Kabupaten Maros. Tujuan dari penelitian ini adalah untuk menganalisis pembentukan Larva Aedes aegypti terhadap temephos pada DBD Di Kelurahan Turikale Kecamatan Turikale Kabupaten Maros pada kisaran konsentrasi. Metode penelitian ini adalah eksperimen dengan menentukan pada kertas saring telur menempel dan selanjutnya dilakukan rearing dimana telur Aedes aegypti berubah menjadi jentik, dan di uji status kerentanan temephos terhadap larva Ae.aegypti.Penelitian dilakukan dengan uji kerentanan terhadap larva berdasarkan standar WHO (Suceptability Test). Hasil menunjukkan rata-rata kematian larva pada setiap konsentrasi 0,005 mg/L, 0,01 mg/L, 0,02 mg/L dan 0,03 mg/L menunjukkan kematian larva 100% setelah kontak dengan temephos.Kata Kunci : Larva, Temephos, Aedes aegypti Sp
HUBUNGAN PERILAKU MASYARAKAT DALAM PENERAPAN STBM PILAR 1 DAN 3 DI DESA BATARA KEC. LABAKKANG. KAB. PANGKEP
Authors: Syam Syamsuddin , Sahani Wahyuni , Shaliha Mar’atus 
Published: December 2021

Salah satu upaya pemerintah dalam menaikkan derajat kesehatan masyarakat melalui program STBM. Pelaksanaan program STBM dimulai dari pilar pertama yaitu Stop BABs dan pilar ketiga yaitu pengelolaan makanan dan minuman rumah tangga. Berdasarkan data yang ada di Puskesmas Taraweang tahun 2017 Tentang STBM Pilar 1 dan 3 di Desa Batara Kecamatan Labakkang Kabupaten Pangkep jumlah penduduk 4549 dan jumlah penduduk 1166 jiwa, yang menggunakan air bersih sebanyak 833 orang\keluarga,sekitar (82%), air minum 1009 sarana (86,54%), dan jamban keluarga sebanyak 1182 (101,37%). Penelitian ini adalah jenis penelitian pada bentuk survey yang bersifat observasional analitik menggunakan metode pendekatan cross-sectional. Adapun tujuan penelitian ini untuk mengetahui Bagaimana Hubungan Perilaku Masyarakat Dalam Penerapan STBM Pilar 1 dan 3 Di Desa Batara Kec. Labakkang Kab. Pangkep. Sampel yang diambil pada penelitian ini sebanyak 100 rumah Pengambilan sampel dilakukan menggunakan Sistematik Random Sampling yang merupakan modifikasi dari sampel random sampling. Hasil penelitian ini berdasarkan olah data yang dilakukan menggunakan SPSS uji Chi Square ada hubungan pengetahuan dengan STBM pilar 1 diperoleh hasil 0,000 <0,05, sedangkan tidak ada hubungan antara pengetahuan dengan STBM pilar 3 diperoleh hasil 0,568 >0,05. Ada hubungan antara sikap dengan STBM pilar 1 diperoleh hasil 0,038 <0,05, sedangkan ada hubungan antara sikap dengan STBM pilar 3 diperoleh hasil 0,000<0,05. Dan ada hubungan antara tindakan dengan STBM pilar 1 diperoleh hasil 0,021 <0,05, sedangkan ada hubungan antara tindakan dengan STBM pilar 3 diperoleh hasil 0,000 <0,05. Diharapkan kepada masyarakat agar lebih berperan aktif dalam penerapan STBM.Kata Kunci : Hubungan, Perilaku, STBM Pilar 1 dan 3
IDENTIFIKASI KEBERADAAN LARVA CACING PITA (Taenia solium) PADA JENIS OLAHAN DAGING BABI DI KOTA MAKASSAR
Authors: Tangkeallo Gladys Libra Eni , Inayah Inayah 
Published: December 2021

Ketersediaan pangan hewani yang aman, sehat dan utuh merupakan hal yang sangat berpengaruh dalam pembangunan di bidang pangan.Salah satu bahan pangan yang mengandung nilai gizi ialah daging. Mikroorganisme seperti parasit pada daging babi dapat menyebabkan penyakit. Perlunya mengetahui keberadaan larva cacing pita (Taenia solium) pada jenis olahan daging babi khususnya di Kota Makassar. Tujuan dari penelitian ini adalah untuk mengetahui keberadaan larva cacing pita pada jenis olahan daging babi di Kota Makassar. Jenis penelitian ini adalah penelitian survey deskriptif ialah untuk menggambarkan keberadaan larva cacing pita (Taenia solium) pada daging babi mentah dan daging babi olahan di warung makan olahan daging babi Kota Makassar. Sampel dalam penelitian ini terdiri dari 16 sampel yang diambil dari 4 daging babi mentah dan 12 makanan olahan daging babi di Kota Makassar. Hasil Penelitian ini menunjukkan hasil identifikasi 4 (empat) sampel daging babi mentah dari jenis olahan masak bambu (Pa’piong), jenis olahan bakar (Sate), jenis olahan tumis (Tumis usus) dan Jenis Olahan Panggang (Babi Panggang) serta 3 (tiga) jenis olahan daging babi ialah dari jenis olahan masak bambu (Pa’piong), jenis olahan bakar (Sate), dan Jenis Olahan Panggang (Babi Panggang) dinyatakan positif mengandung kista cacing pita(Taenia solium). Kesimpulan dalam penelitian ini adalah proses pengolahan meliputi waktu, suhu dan ketebalan daging dapat berpengaruh pada tingkat kematangan dan keberadaan larva cacing pita (Taenia solium), sehingga kondisi olahan daging babi di Kota Makassar masuk dalam kriteria tidak memenuhi syarat. Kata Kunci : Cacing Pita, Daging Babi, Olahan Makanan
FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN KECELAKAAN KERJA DI PT. SEMEN BOSOWA MAROS
Authors: Wulandari Dini Putri , Haderiah Haderiah 
Published: December 2021

Kecelakaan kerja dapat berdampak secara langsung dan tidak langsung. Upaya pencegahan terjadinya kecelakaan kerja dapat dilakukan dengan mengetahui faktor penyebab kecelakaan kerja. Penelitian ini bertujuan mengetahui faktor yang berhubungan dengan kejadian kecelakaan kerja di PT. Semen Bosowa Maros. Jenis penelitian ini adalah survei analitik, dengan rancangan cross sectional. Sampel penelitian ini berjumlah 130 dengan menggunakan rumus slovin. Teknik pengambilan sampel yaitu meode cluster sampling. Analisis data menggunakan uji chi square. Hasil penelitian menunjukkan ada hubungan kejadian kecelakaan kerja dengan shift kerja (p=0,003), tidak ada hubungan kejadian kecelakaan kerja dengan masa kerja (p=0,614), dan ada hubungan kejadian kecelakaan kerja dengan beban kerja (p=0,002). Kesimpulan dari penelitian ini, ada hubungan kejadian kecelakaan kerja di PT. Semen Bosowa Maros dangan shift kerja dan beban kerja, serta tidak ada hubungan kejadian kecelakaan kerja di PT. Semen Bosowa Maros dengan masa kerja. Diharapkan kepada pihak perusahaan untuk menyediakan air minum di setiap unit produksi. Kata Kunci : Shift Kerja, Masa Kerja, Beban Kerja dan Kecelakaan Kerja
ANALISIS BIONOMIK NYAMUK DENGAN PENULARAN DBD DI WILAYAH PUSKESMAS TAKALALA KEC. MARIORIWAWO KAB. SOPPENG
Authors: Rasjid Ashari , Muriadi Muriadi 
Published: December 2021

Demam berdarah dengue (DBD) merupakan penyakit yang disebabkan oleh virus dengue dan ditularkan oleh nyamuk Aedes aegypti. Penyakit dapat menyerang semua orang dan menyebabkan kematian, mudah menulari anak-anak dan sering menimbulkan wabah penyakit. Deman Berdarah Dengue tidak menular melalui kontak manusia secara langsung,tetapi dapat ditularkan melalui gigitan nyamuk. Penelitian ini bertujuan untuk mengetahui bionomik nyamuk dengan penularan DBD di wilayah Puskesmas Takalala Kec.marioriwawo Kab.Soppeng. Jenis penelitian ini survey observasional analitik dengan pendekatan secara cross sectional,menggunakan kuesioner dan uji chi square. Sampel penelitian ini adalah 100 orang yang diwawancarai ditentukan secara purposive sampling. Ada hubungan antara hasil penelitian tempat perindukan nyamuk dengan kejadian DBD desa Congko yaitu hasil uji chi square diperoleh nilai p= 0,022 < α=0,05 serta tempat perindukan nyamuk yang positif dan pernah menderita DBD lebih tinggi sebanyak 71% dibanding yang negative 29%, ada hubungan antara kebiasaan istirahat nyamuk dengan kejadian DBD dengan hasil uji chi square diperoleh nilai P=0,007 > α=0,05 serta kebiasaan istirahat nyamuk yang positif dan pernah menderita DBD 93% dibanding dengan yang negatif 7%.Kesimpulan dari penelitian ini adalah ada hubungan antara tempat perindukan nyamuk dan kebiasaan istirahat nyamuk dengan kejadian DBD. Sehingga disarankan msyarakat agar lebih memperhatikan dan menjaga kebersihan lingkungan rumah dan melaksanakan 3M plus di dalam maupun di lingkungan rumah. Dengan merubah prilaku dan kebiasaan tersebut maka penularan DBD dapat berkurangKata Kunci : DBD,Ae aegypti, tempat perindukan nyamuk