bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Microvascular Decompression and Two Isocenters Gamma Knife for the Treatment of Trigeminal Neuralgia Caused by Vertebrobasilar Dolichoectasia
Authors: Zhao Zhen , Chai SongShan , Wang JiaJing , Jiang XiaoBing , Nie ChuanSheng , Zhao HongYang 
Published: September 2021

Background: Vertebrobasilar dolichoectasia (VBD) is one of the rare causes of trigeminal neuralgia (TN). The common surgical treatments for patients with TN caused by VBD (VBD-TN) are microvascular decompression (MVD) and Gamma Knife radiosurgery (GKRS). However, the therapeutic effects of the two methods have not been clinically compared, so this study was performed to evaluate the treatment outcomes of MVD and GKRS for patients with VBD-TN.Methods: The retrospective study was performed from March 2011 to March 2019 in Wuhan Union Hospital. A total of 80 patients diagnosed with VBD-TN were included in this study, and they were divided into the MVD group (n = 46) and GKRS group (n = 34) according to the surgical methods. The imaging data, intraoperative findings, treatment outcomes, and complications of the two groups were analyzed and compared. Meanwhile, the influencing factors of the treatment effect are also explored on the two groups.Results: Patients who underwent MVD were younger than patients who underwent GKRS (median ages were 61.1 and 65.4 years old, respectively, p = 0.03). The median follow-up was 61.1 months for the MVD group and 56.8 months for the GKRS group. The favorable outcomes [Barrow Neurological Institute (BNI) pain score, BNI scores I–II] occurred in 97.8% of patients treated with MVD and in 78.9% of patients treated with GKRS (p = 0.009). The favorable outcomes in the percentage of patients after MVD 1, 3, 5, and 7 years were 95.7, 85.1, 74.2, and 74.2%, respectively, whereas the corresponding percentages after GKRS were 76.5, 66.2, 56.6, and 47.2%, respectively (p = 0.031). The postoperative complications (except facial numbness) in the MVD group were higher than those in the GKRS group (p = 0.036), but the incidence of new and worsening facial numbness was lower in the GKRS group (p &lt; 0.001).Conclusions: MVD is superior to GKRS in obtaining and maintaining favorable outcomes for patients with VBD-TN, but it also comes with more complications other than facial numbness. Thus, the treatment program can be tailored to a patient's unique condition and wishes.
High Counts of CD68+ and CD163+ Macrophages in Mantle Cell Lymphoma Are Associated With Inferior Prognosis
Authors: Li Philippa , Yuan Ji , Ahmed Fahad Shabbir , McHenry Austin , Fu Kai , Yu Guohua , Cheng Hongxia , Xu Mina L. , Rimm David L. , Pan Zenggang 
Published: September 2021

BackgroundLymphoma-associated macrophages (LAMs) are key components in the lymphoma microenvironment, which may impact disease progression and response to therapy. There are two major subtypes of LAMs, CD68+ M1 and CD163+ M2. M2 LAMs can be transformed from M1 LAMs, particularly in certain diffuse large B-cell lymphomas (DLBCL). While mantle cell lymphoma (MCL) is well-known to contain frequent epithelioid macrophages, LAM characterization within MCL has not been fully described. Herein we evaluate the immunophenotypic subclassification, the expression of immune checkpoint molecule PD-L1, and the prognostic impact of LAMs in MCL.Materials and MethodsA total of 82 MCL cases were collected and a tissue microarray block was constructed. Immunohistochemical staining was performed using CD68 and CD163, and the positive cells were recorded manually in four representative 400× fields for each case. Multiplexed quantitative immunofluorescence assays were carried out to determine PD-L1 expression on CD68+ M1 LAMs and CD163+ M2 LAMs. In addition, we assessed Ki67 proliferation rate of MCL by an automated method using the QuPath digital imaging analysis. The cut-off points of optimal separation of overall survival (OS) were analyzed using the X-Tile software, the SPSS version 26 was used to construct survival curves, and the log-rank test was performed to calculate the p-values.ResultsMCL had a much higher count of M1 LAMs than M2 LAMs with a CD68:CD163 ratio of 3:1. Both M1 and M2 LAMs were increased in MCL cases with high Ki67 proliferation rates (&gt;30%), in contrast to those with low Ki67 (&lt;30%). Increased number of M1 or M2 LAMs in MCL was associated with an inferior OS. Moreover, high expression of PD-L1 on M1 LAMs had a slightly better OS than the cases with low PD-L1 expression, whereas low expression of PD-L1 on M2 LAMs had a slightly improved OS, although both were not statistically significant.ConclusionsIn contrast to DLBCL, MCL had a significantly lower rate of M1 to M2 polarization, and the high levels of M1 and M2 LAMs were associated with poor OS. Furthermore, differential PD-L1 expressions on LAMs may partially explain the different functions of tumor-suppressing or tumor-promoting of M1 and M2 LAMs, respectively.
Association Between Assisted Reproductive Technology and White Matter Injury in Premature Infants: A Case-Control Study
Authors: Huang Xuejiao , Fu JianHua 
Published: September 2021

Objectives: Whether there is a link between assisted reproductive technology (ART) and brain damage in premature infants remains unclear. The aim of this study was to determine whether premature infants conceived by ART are at a greater risk of developing white matter injury (WMI), as detected by magnetic resonance imaging (MRI) or diffusion-weighted imaging (DWI) within 14 days, than those naturally conceived (NC).Methods: A retrospective case-control study was conducted on singleton premature infants with a gestational age of ≥28 weeks and &lt;34 weeks delivered between 2017 and 2019 at Shengjing Hospital, China Medical University. This study included 638 live births that were stratified into case group (n = 218) and control group (n = 420), depending on the presence or absence of WMI. The exposure proportion of ART was compared between the case and control groups, and a logistic regression model was used to identify whether ART was an independent risk factor for WMI.Results: In the univariate analysis, the exposure proportion of ART conception was higher in cases than in controls (12.84 vs. 7.38%, p = 0.024). According to the multivariable analysis, after adjustment for other variables, the association between ART and WMI remained significant (1.82; 95% confidence interval, 1.04–3.21; P = 0.038).Conclusions: Singleton premature infants conceived by ART have a higher risk of WMI than NC infants. Given that ART is an independent risk factor for WMI in premature infants, more attention should be paid to neurodevelopmental outcomes in this group.
Effect of Pharmacogenetics Variations on Praziquantel Plasma Concentrations and Schistosomiasis Treatment Outcomes Among Infected School-Aged Children in Tanzania
Authors: Mnkugwe Rajabu Hussein , Minzi Omary , Kinung’hi Safari , Kamuhabwa Appolinary , Aklillu Eleni 
Published: September 2021

Studies on pharmacogenetics of praziquantel (PZQ) and its relevance on plasma drug concentrations and schistosomiasis treatment outcomes are lacking. We investigated the effect of pharmacogenetics variations of PZQ on plasma drug levels and schistosomiasis treatment outcomes among infected Tanzanian school-aged children. A total of 340 Schistosoma mansoni infected children were enrolled and treated with single-dose PZQ. Stool samples analysis was done by thick smear Kato-Katz technique, and treatment efficacy was assessed at 3-weeks post-treatment. Safety was assessed within 4 h after PZQ intake. Plasma samples were collected at 4 h post-dose, and PZQ and trans-4-OH-PZQ concentrations were quantified using UPLCMS/MS. Genotyping for CYP3A4*1B, CYP3A5 (*3, *6, *7), CYP2C19 (*2, *3, *17), and CYP2C9 (*2, *3) were done by Real-Time PCR. The median age (range) of the study participants was 12 years (7–17). There was a significant association of CYP2C19 genotypes with PZQ concentrations and its metabolic ratio (trans-4-OH-PZQ/PZQ). PZQ concentration was significantly higher among CYP2C19 (*2, *3) carriers than CYP2C19 *1/*1 and CYP2C19 *17 carriers (ultra-rapid metabolizers) (p = 0.04). The metabolic ratio was significantly higher among CYP2C19*17 carriers than CYP2C19 (*2, *3) carriers (p = 0.01). No significant effect of CYP3A4, CYP3A5, CYP2C19, and CYP2C9 genotypes on treatment efficacy or adverse events were observed. Baseline infection intensity and CYP3A5 genotype were significant predictors of treatment associated-adverse events. In conclusion, CYP2C19 genotype significantly affects plasma PZQ concentration and its metabolic ratio. For the first time, we report the importance of pharmacogenetic variation for the treatment of schistosomiasis, a neglected tropical disease.
Infodemic vs. Pandemic Factors Associated to Public Anxiety in the Early Stage of the COVID-19 Outbreak: A Cross-Sectional Study in China
Authors: Xu Jian , Liu Cong 
Published: September 2021

Introduction: Every outbreak of an epidemic or pandemic disease is accompanied by the tsunami of information, which is also known as the infodemic. Infodemic makes it hard for people to find trustworthy sources and reliable guidance when they need it, and causes social panic about health, widens the gaps between races and regions, and even brings the social chaos all over the world. While most researchers and related parties made efforts to control the inaccurate information spreading online during the COVID-19 pandemic, the infodemic influence caused by the overload of accurate information were almost or completely ignored, and this will hinder the control of infodemic in future public health crises. This study aims to explore the infodemic vs. pandemic influence on people's psychological anxiety across different media sources in the early stage of the COVID-19 outbreak in China.Methods: A cross-sectional study using online survey method was conducted by a data-collection service provider in April 2020. A total of 1,117 valid samples were finally collected from 5,203 randomly invited members via webpages and WeChat. The sample distribution covered the 30 provincial administrative divisions of mainland China.Results: Hierarchical regression analysis for the potential pandemic sources and infodemic sources of psychological anxiety showed that the infodemic factors of attention to the coronavirus information (β = 0.154, p &lt; 0.001) and commercial media exposure (β = 0.147, p &lt; 0.001) is positively related to the level of anxiety. Statistics indicated that influence of the infodemic factors is over and above that of the pandemic factors (ΔR2 = 0.054, F = 14.199, and p &lt; 0.001). Mediation analysis showed that information overload (B = 0.155, Boot SE = 0.022, and 95% Boot CI [0.112, 0.198]) mediates the link between attention to coronavirus information and anxiety; both information overload (B = 0.035, Boot SE = 0.014, and 95% Boot CI [0.009, 0.062]) and media vicarious traumatization (B = 0.106, Boot SE = 0.017, and 95% Boot CI [0.072, 0.140]) mediate the link between commercial media exposure and anxiety.Conclusion: This study suggested that the influence of infodemic with mixed accurate and inaccurate information on public anxiety does exist, which could possibly go beyond that of the pandemic. Information overload and vicarious traumatization explain how infodemic may be associated to public anxiety. Finally, commercial media could be a major source of infodemic in the Chinese media context. Implications for the related parties were discussed.
Risk Factors of Preterm Birth in Nepal: A Hospital-Based Matched Case-Control Study
Authors: Acharya Richa , Khanal Pratik , Bhattarai Hari Krishna , Amatya Archana 
Published: September 2021

Background: Preterm birth is a significant cause of neonatal death globally. Nepal is in the 20th position in the world, with the highest rate of preterm deliveries. The risk factors of preterm birth have not been fully identified and established in Nepal. The study aims to identify risk factors of preterm birth among women who underwent delivery in a tertiary maternal hospital in Nepal.Methods: This study employed a hospital-based matched case-control study design. The case included women who delivered before 37 weeks of gestation, and women who delivered between 37 and 42 weeks of gestation served as controls. The ratio of the case to control was 1:2, and matching was done for the type of delivery. The first author collected the data in the Paropakar Maternity and Women's Hospital between December 2015 and January 2016. Face-to-face interviews were conducted using a structured questionnaire. Backward conditional logistic regression was performed to identify the independent risk factors of preterm birth.Results: Antihelminthic treatment during pregnancy was found to be protective for preterm birth. Women performing intensive physical work during their pregnancy and women exposed to indoor air pollution were more likely to have a preterm birth than women not performing intensive physical work and women not exposed to indoor pollution, respectively.Conclusions: Women who had not consumed antihelminthic drugs per protocol, those exposed to indoor air pollution, and those who performed intensive work during pregnancy were at higher risk for preterm birth. Maternal health programs can encourage women to consume antihelminthic drugs, take proper rest during pregnancy, and prevent indoor pollution exposure.
Meta-Analysis of 3D Printing Applications in Traumatic Fractures
Authors: Yang Sha , Lin Huapeng , Luo Cong 
Published: September 2021

Background: Traumatic fracture is a common orthopaedic disease, and application of 3D printing technology in fracture treatment, which entails utilisation of pre-operative printed anatomic fracture model, is increasingly gaining popularity. However, effectiveness of 3D printing-assisted surgery lacks evidence-based findings to support its application.Materials and Methods: Embase, PubMed and Cochrane Library databases were systematically searched until October, 2020 to identify relevant studies. All randomised controlled trials (RCTs) comparing efficacy of 3D printing-assisted surgery vs. conventional surgery for traumatic fractures were reviewed. RevMan V.5.3 software was used to conduct meta-analysis.Results: A total of 12 RCTs involving 641 patients were included. Pooled findings showed that 3D printing-assisted surgery had shorter operation duration [standardised mean difference (SMD) = −1.52, 95% confidence interval (CI) – 1.70 ~ −1.34, P &lt; 0.00001], less intraoperative blood loss (SMD = 1.34, 95% CI 1.74 ~ 0.94, P &lt; 0.00001), fewer intraoperative fluoroscopies (SMD = 1.25, 95% CI 1.64 ~ 0.87, P &lt; 0.00001), shorter fracture union time (SMD = −0.15, 95% CI −0.25 ~ −0.05, P = 0.003), and higher rate of excellent outcomes (OR = 2.40, 95% CI 1.07 ~ 5.37, P = 0.03) compared with conventional surgery. No significant differences in complication rates were observed between the two types of surgery (OR = 0.69, 95% CI 0.69 ~ 1.42, P = 0.32).Conclusions: Indicators including operation duration, intraoperative blood loss, number of intraoperative fluoroscopies, fracture union time, and rates of excellent outcomes showed that 3D printing-assisted surgery is a superior alternative in treatment of traumatic fractures compared with conventional surgery. Moreover, the current study did not report significant differences in incidence of complications between the two approaches.Systematic Review Registration: CRD42021239507.
TWO IMAGES OF MAKARENKO'S MAIN OPPONENT: VARIABILITY OF VALENTINA DUCHEN'S LIFE PATH
Authors: Tkachenko A. , Zhdanova-Nedilko O. 
Published: September 2021

The article is devoted to the coverage of the eventful life path of A. Makarenko’s main ideological opponent – an active revolutionary, a well-known figure in national education, author of numerous pedagogical publications Valentina Diushen.The nature of V. Diushen's social origin and education, details of her revolutionary and educational-managerial activity, publishing activity are revealed, little-known biographical information about her family members is presented: the first husband – Borys Diushen, the second husband – Volodymyr Aussem, son – Ihor Diushen. The chronology of all known controversial moments of professional dialogue of V. Diushen and A. Makarenko is presented in detail. For the first time in the Makarenko literature, documentary evidence of A. Makarenko's reports on V. Duchen's affiliation with the Trotskyi opposition is presented.The set of found materials presents Valentina Diushen as a large-scale personality of a highly professional, active, able-bodied, and principled figure in the history of national education. However, it is the ambiguity, the contradiction of this figure that determines its opposed assessments by contemporaries.The conflict between Makarenko and Diushen must be viewed in two planes, the objective and the subjective. On the one hand, the tension of their professional relations as representatives of innovative pedagogy is evidence of the struggle that always accompanies the assertion of any new doctrine. On the other hand, both of these figures were extremely bright, original figures and, at the same time, extremely ambitious personalities. At the same time, the ambition and irresistibility of V. Diushen towards the self-confident but non-partisan head of the provincial institution were dictated by its administrative status, membership in the political elite, and metropolitan education and social background.So far, it is difficult to explain whether Diushen's opposition in any way influenced her pedagogical views, but it should be noted that A. Makarenko in his criticism of her makes a special emphasis on this circumstance.
OUTSTANDING MASTERS OF UKRAINIAN FOLK ART: BIOGRAPHICAL NARRATIVES
Authors: Mokhirieva Yu. 
Published: September 2021

The article considers the problems of creating a semantic component of the pedagogical narrative (based on biographical studies of prominent personalities of Ukrainian national art) as an effective method of professional-pedagogical education of teachers of fine arts. Among the most representative phenomena of Ukrainian culture are the works by Hanna Sobachko-Shostak, Kateryna Bilokur, Oleksandr and Nadiia Babenko, the Piliuhin family. As a result of the research, the individual features of our selected outstanding masters of Ukrainian folk art were clarified, the influence of the social environment and the family on the formation and creative development of outstanding Ukrainian folk artists was determined.The Department of Fine Arts of Poltava V. G. Korolenko National Pedagogical University has developed biographical narratives about outstanding masters of Ukrainian traditional folk art, which are used in teaching the following subjects: "History of Ukrainian Fine Arts", "History of Decorative and Applied Arts", "Basics of Decorative Composition". The study proved the effectiveness and feasibility of introducing biographical narratives in the training of future teachers of fine arts.
PREPARING EDUCATORS FOR THE USE OF INNOVATIVE TECHNOLOGIES FOR THE DEVELOPMENT OF CREATIVE STORYTELLING OF PRESCHOOLERS
Authors: Kotelianets Ju. 
Published: September 2021

Speech competence is one of the leading basic characteristics of personality formed in ontogenesis. Mastering coherent speech is a component of pre-school children’s speech competence, which provides successful preparation for school. Therefore, the task of coherent speech development occupies a central place in the overall system of work on speech development in a pre-school educational institution. Modernization of pre-school education in Ukraine requires the implementation of innovations in the practice of working with pre-school children. Future pre-school teachers of the XXI century should be able to use innovative pedagogical technologies that will help them find their place in the chosen profession. In the process of studying in a higher educational institution, future pre-school teachers should master innovative technologies for the development of creative storytelling of preschoolers. The speech of older preschoolers is more coherent in situations based on visibility. It is facilitated by a modified method of perception of the image depicted in the picture by different senses, as well as modeling technology. In the process of studying in a higher educational institution, students should master the sequence of work on the formation of skills to compose a creative story: It is advisable to teach future pre-school teachers to use during classes V. Propp’s cards and give them instructions and recommendations how to build a methodological correct sequence of work with them. Thanks to the usage of the proposed method, the child’s creative potential is developed and realized, acquiring real forms of expressiveness.
THE INNER GAME CONCEPT AS A METHOD OF MUSIC COACHING
Authors: Petreniuk D. 
Published: September 2021

Maximizing musician’s potential and creating effective performing skills in the process of their musical education and during the further professional development, as well as overcoming their own fears, doubts and limiting beliefs, particularly during performing in public, are still actual tasks both for musicians and their teachers.One effective approach to developing musician's creative potential is coaching. Coaching is based on a dialogue between the coach and the student (coachee); the coach proposes a series of questions aimed on assisting the student in finding their own solution of the problem. It has been known for a long time that the inner state of a person significantly impacts effectiveness of their actions. The Inner Game concept proposed by Timothy Gallwey is a coaching methodology designed to overcome inner obstacles in reaching person’s goals. Those obstacles are of mental nature and include loss of concentration, nervousness and self-doubt. What distinguishes the Inner Game from other coaching methods is that it utilizes statements and tasks that often do not require the student’s verbal answer (moreover, such verbal answer often cannot be given at all), but rather stimulate them to pay attention to their senses and to experiment (for example, in finding optimal position during playing an instrument or choosing proper dynamics for a certain music piece).The first principle of the Inner Game points out the fact that the quality of person’s performance depends not only on their potential (talent, skills, knowledge, etc.), but also on the level of self-interference (mental digression, untimely self-criticism, lack of confidence, fear, etc.).Traditional approach to improving performance suggests working on increasing the potential; the idea of the Inner Game is to decrease self-interference in order to bring the quality of the performance as close to the potential as possible.To describe the inner dialogue taking place inside person’s mind, notions of Self 1 and Self 2 are used. Self 1 is the source of self-interference, it contains person’s ideas about how the thins should be, their judgements and associations. Self 2 is our inner potential, it includes our natural talents, abilities and skills. The methods of the Inner Game are used to decrease self-interference (impact of the Self 1) and help the performer to enter the ideal state during performance, the state of relaxed concentration.