bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of meatal cleaning in the prevention of catheter-associated urinary tract infections and bacteriuria: an updated systematic review and meta-analysis
Authors: Mitchell Brett , Curryer Cassie , Holliday Elizabeth , Rickard Claire M , Fasugba Oyebola 
Published: June 2021

ObjectiveA systematic review on meatal cleaning prior to urinary catheterisation and post catheterisation and reduces the risk catheter-associated urinary tract infections (CAUTIs) and bacteriuria was published in 2017, with further studies undertaken since this time. The objective of this paper is to present an updated systematic review on the effectiveness of antiseptic cleaning of the meatal area for the prevention of CAUTIs and bacteriuria in patients who receive a urinary catheter.DesignSystematic review.Data sourcesElectronic databases Cochrane Library, PubMed, Embase, The Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline and Academic Search Complete were searched from 1 January 2016 and 29 February 2020.Eligibility criteriaRandomised controlled trials (RCTs) and quasi-experimental studies evaluating the use of antiseptic, antibacterial or non-medicated agents for cleaning the meatal, periurethral or perineal areas before indwelling catheter insertion or intermittent catheterisation or during routine meatal care.Data extraction and synthesisData were extracted using the Cochrane Collaboration’s data collection form for RCTs and non-RCTs. Data were extracted by one researcher and then checked for accuracy by a second researcher.ResultsA total of 18 studies were included. Some potential benefit of using antiseptics, compared with non-antiseptics for meatal cleaning to prevent bacteriuria and or CAUTI was identified (OR 0.84, 95% CI 0.69 to 1.02; p=0.071). Antiseptics (chlorhexidine or povidine-iodine) may be of value for meatal cleaning on the incidence of CAUTI, compared with comparator agents (saline, soap or antimicrobial cloths) (OR=0.65, 95% CI 0.42 to 0.99; p=0.047).ConclusionThere is emerging evidence of the role of some specific antiseptics (chlorhexidine) prior to urinary catheterisation, in reducing CAUTIs, and some potential benefit to the role of antiseptics more generally in reducing bacteriuria.PROSPERO registration numberCRD42015023741.
Clinical activity of durvalumab for patients with advanced mismatch repair-deficient and repair-proficient endometrial cancer. A nonrandomized phase 2 clinical trial
Authors: Antill Yoland , Kok Peey-Sei , Robledo Kristy , Yip Sonia , Cummins Michelle , Smith Deborah , Spurdle Amanda , Barnes Elizabeth , Lee Yeh Chen , Friedlander Michael , Baron-Hay Sally , Shannon Catherine , Coward Jermaine , Beale Philip , Goss Geraldine , Meniawy Tarek , Lombard Janine , Andrews John , Stockler Martin R , Mileshkin Linda 
Published: June 2021

BackgroundIn this study, we assessed the activity of durvalumab, an antibody to programmed death ligand-1, in two cohorts of women with advanced endometrial cancers (AEC)—mismatch repair proficient (pMMR) and mismatch repair deficient (dMMR).MethodsA multicenter phase two study was performed in women with AEC with pMMR tumor progressing after one to three lines of chemotherapy and women with AEC with dMMR tumor progressing after zero to three lines of chemotherapy. Mismatch repair status was based on immunohistochemistry expression. All women received durvalumab 1500 mg given every 4 weeks until progression or unacceptable toxicity. The primary endpoint was objective tumor response by RECIST V.1.1 modified for immune-based therapeutics.ResultsSeventy-one women were recruited: 35 dMMR and 36 pMMR. Median follow-up was 19 vs 21 months in dMMR versus pMMR, respectively. Median age was 67 years. Histology in dMMR versus pMMR included endometrioid (94% vs 57%) and serous (0% vs 31%) and was high grade in 26% vs 74%. The objective tumor response rate (OTRR) in the dMMR cohort was 47% (17/36, 95% CI 32 to 63), including 6 complete responses and 11 partial responses (PRs)) vs 3% in the pMMR cohort (1/35, 95% CI 1 to 15, PR). In the dMMR cohort, durvalumab was the first-line therapy in 58% (OTRR 57%) and the second-line therapy in 39% (OTRR 38%). Median progression-free survival was 8.3 months in the dMMR cohort vs 1.8 months in the pMMR cohort. The 12-month overall survival (OS) rate was 71% in dMMR vs 51% in pMMR, with median OS not reached for dMMR vs 12 months for pMMR. Immune-related adverse events occurred in 14 women, mostly grades 1–2.ConclusionDurvalumab monotherapy showed promising activity and acceptable safety in AEC with dMMR regardless of prior lines of chemotherapy, but activity was limited in AEC with pMMR.Trial registration numbersANZGOG1601, ACTRN12617000106336, and NCT03015129.
Creation and investigation of electronic defects on methylammonium lead iodide (CH$$_3$$NH$$_3$$PbI$$_3$$) films depending on atmospheric conditions
Authors: Gokhan YILMAZ 
Published: June 2021

AbstractMethylammonium lead iodide (MAPbI$$_3$$

3

) (CH$$_3$$

3

NH$$_3$$

3

PbI$$_3$$

3

) is popular material for edge technology application, but it still includes many uncertainties. Particularly, molecular and electronic degradation (electronic defect distribution) and mobility–lifetime product still hold many mysteries. Stemming from the atmospheric or light-induced degradation, mobility–lifetime product changes are still unknown and haven’t been studied up to now. In this study, mobility–lifetime product change was investigated depending on degradation source such as atmospheric and light soaked. MAPbI$$_3$$

3

films were deposited by thermal chemical vapor deposition (thermal CVD). Structural analysis was done by X-ray diffraction (XRD), respectively. Deposited MAPbI$$_3$$

3

films were exposed to laboratory ambient, vacuum atmosphere, deionized water vapor (DIWV) atmosphere and UV light soaking at constant temperature (300K) to define changes on mobility–lifetime product.
Multi-ciliated microswimmers–metachronal coordination and helical swimming
Authors: Rode Sebastian , Elgeti Jens , Gompper Gerhard 
Published: June 2021

Abstract
The dynamics and motion of multi-ciliated microswimmers with a spherical body and a small number N (with $$5< N < 60$$

5
<
N
<
60

) of cilia with length comparable to the body radius, is investigated by mesoscale hydrodynamics simulations. A metachronal wave is imposed for the cilia beat, for which the wave vector has both a longitudinal and a latitudinal component. The dynamics and motion is characterized by the swimming velocity, its variation over the beat cycle, the spinning velocity around the main body axis, as well as the parameters of the helical trajectory. Our simulation results show that the microswimmer motion strongly depends on the latitudinal wave number and the longitudinal phase lag. The microswimmers are found to swim smoothly and usually spin around their own axis. Chirality of the metachronal beat pattern generically generates helical trajectories. In most cases, the helices are thin and stretched, i.e., the helix radius is about an order of magnitude smaller than the pitch. The rotational diffusion of the microswimmer is significantly smaller than the passive rotational diffusion of the body alone, which indicates that the extended cilia contribute strongly to the hydrodynamic radius. The swimming velocity is found to increase with the cilia number N with a slightly sublinear power law, consistent with the behavior expected from the dependence of the transport velocity of planar cilia arrays on the cilia separation.

Graphic abstract
Graphene–TiO2for scattering layer in photoanodes of dye-sensitized solar cell
Authors: Min Kao-Wei , Chao Shi-Mian , Yu Ming-Ta , Ho Chi-Ting , Chen Pin-Ru , Wu Tung-Lung 
Published: June 2021

The scattering layer in the TiO2photoanode (PAs) of dye-sensitized solar cells (DSSCs) is doped with single-layer graphene (G), and DSSC is prepared by doctor blade coating method. A small amount of graphene (0.0016 wt.%) in a graphene aqueous solution (G-AS) and a G-TiO2paste was prepared to make 2–20 wt.% of G-AS in the deionized water (DIW). The UV-Vis measurement results show that the TiO2scattering layers doped with graphene effectively improve the visible light absorption intensity of DSSC PAs and increase the current density (Jsc) from 13.84 mA/cm2to 16.20 mA/cm2. The Electrochemical Impedance Spectroscopy (EIS) measurement showed that the internal structural impedance Rk [Formula: see text] decreased from 12.086 [Formula: see text] (without graphene doping) to 9.875 [Formula: see text] at 5 wt.% of the graphene doping. The photoelectric conversion efficiency (PCE) increased from 6.56% of the original un-doped graphene to the maximum PCE value of 7.57% at 5 wt.%. The results show that the best PCE is obtained when the concentration of G-AS is 5 wt.%.
A Nomogram Prediction of Length of Hospital Stay in Patients with COVID-19 Pneumonia: A Retrospective Cohort Study
Authors: Li Kang , Zhang Chi , Qin Ling , Zang Chaoran , Li Ang , Sun Jianping , Zhao Yan , Feng Yingmei , Zhang Yonghong 
Published: June 2021

Assessing the length of hospital stay (LOS) in patients with coronavirus disease 2019 (COVID-19) pneumonia is helpful in optimizing the use efficiency of hospital beds and medical resources and relieving medical resource shortages. This retrospective cohort study of 97 patients was conducted at Beijing You’An Hospital between January 21, 2020, and March 21, 2020. A multivariate Cox proportional hazards regression based on the smallest Akaike information criterion value was used to select demographic and clinical variables to construct a nomogram. Discrimination, area under the receiver operating characteristic curve (AUC), calibration, and Kaplan–Meier curves with the log-rank test were used to assess the nomogram model. The median LOS was 13 days (interquartile range [IQR]: 10–18). Age, alanine aminotransferase, pneumonia, platelet count, and PF ratio (PaO2/FiO2) were included in the final model. The C-index of the nomogram was 0.76 (

95
%
confidence

interval

CI

=
0.69
–
0.83

), and the AUC was 0.88 (

95
%
CI
=
0.82
–
0.95

). The adjusted C-index was 0.75 (

95
%
CI
=
0.67
–
0.82

) and adjusted AUC 0.86 (

95
%
CI
=
0.73
–
0.95

), both after 1000 bootstrap cross internal validations. A Brier score of 0.11 (

95
%
CI
=
0.07
–
0.15

) and adjusted Brier score of 0.130 (

95
%
CI
=
0.07
–
0.20

) for the calibration curve showed good agreement. The AUC values for the nomogram at LOS of 10, 20, and 30 days were 0.79 (

95
%
CI
=
0.69
–
0.89

), 0.89 (

95
%
CI
=
0.83
–
0.96

), and 0.96 (

95
%
CI
=
0.92
–
1.00

), respectively, and the high fit score of the nomogram model indicated a high probability of hospital stay. These results confirmed that the nomogram model accurately predicted the LOS of patients with COVID-19. We developed and validated a nomogram that incorporated five independent predictors of LOS. If validated in a future large cohort study, the model may help to optimize discharge strategies and, thus, shorten LOS in patients with COVID-19.
Rejection Sampling Revisit: How to Choose Parameters in Lattice-Based Signature
Authors: Zheng Zhongxiang , Wang Anyu , Qin Lingyue 
Published: June 2021

Rejection sampling technology is a core tool in the design of lattice-based signatures with ‘Fiat–Shamir with Aborts’ structure, and it is related to signing efficiency and signature, size as well as security. In the rejection sampling theorem proposed by Lyubashevsky, the masking vector of rejection sampling is chosen from discrete Gaussian distribution. However, in practical designs, the masking vector is more likely to be chosen from bounded uniform distribution due to better efficiency and simpler implementation. Besides, as one of the third-round candidate signatures in the NIST postquantum cryptography standardization process, the 3rd round version of CRYSTALS-Dilithium has proposed a new method to decrease the rejection probability in order to achieve better efficiency and smaller signature size by decreasing the number of nonzero coefficients of the challenge polynomial according to the security levels. However, it is seen that small entropies in this new method may lead to higher risk of forgery attack compared with former schemes proposed in its 2nd version. Thus, in this paper, we first analyze the complexity of forgery attack for small entropies and then introduce a new method to decrease the rejection probability without loss of security including the security against forgery attack. This method is achieved by introducing a new rejection sampling theorem with tighter bound by utilizing Rényi divergence where masking vector follows uniform distribution. By observing large gaps between the security claim and actual security bound in CRYSTALS-Dilithium, we propose two series of adapted parameters for CRYSTALS-Dilithium. The first set can improve the efficiency of the signing process in CRYSTALS-Dilithium by factors of

61.7
%
and
41.7
%

, according to the security levels, and ensure the security against known attacks, including forgery attack. And, the second set can reduce the signature size by a factor of

14.09
%

with small improvements in efficiency at the same security level.
Sex‐Based Differences in Bleeding Risk After Percutaneous Coronary Intervention and Implications for the Academic Research Consortium High Bleeding Risk Criteria
Authors: Spirito Alessandro , Gragnano Felice , Corpataux Noé , Vaisnora Lukas , Galea Roberto , Svab Stefano , Gargiulo Giuseppe , Siontis George C. M. , Praz Fabien , Lanz Jonas , Billinger Michael , Hunziker Lukas , Stortecky Stefan , Pilgrim Thomas , Capodanno Davide , Urban Philip , Pocock Stuart , Mehran Roxana , Heg Dik , Windecker Stephan , Räber Lorenz , Valgimigli Marco 
Published: June 2021

Background
Female sex was not included among the high bleeding risk (HBR) criteria by the Academic Research Consortium (ARC) as it remains unclear whether it constitutes an HBR condition after percutaneous coronary intervention. We investigated whether female sex associates with HBR and assessed the performance of ARC HBR criteria separately in women and men.

Methods and Results

Among all consecutive patients undergoing percutaneous coronary intervention between 2009 and 2018, bleeding occurrences up to 1 year were prospectively collected and centrally adjudicated. All but one of the originally defined ARC HBR criteria were assessed, and the ARC HBR score generated accordingly. Among 16 821 patients, 25.6% were women. Compared with men, women were older and had lower creatinine clearance and hemoglobin values. After adjustment, female sex was independently associated with access‐site (adjusted hazard ratio, 2.14; 95% CI, 1.22–3.74;
P
=0.008) but not with overall or non–access‐site 1‐year Bleeding Academic Research Consortium 3 or 5 bleeding. This association remained consistent when the femoral but not the radial approach was chosen. The ARC HBR score discrimination, using the original criteria, was lower among women than men (c‐index 0.644 versus 0.688;
P
=0.048), whereas a revised ARC HBR score, in which age, creatinine clearance, and hemoglobin were modeled as continuous rather than dichotomized variables, performed similarly in both sexes.

Conclusions
Female sex is an independent predictor for access‐site bleeding but not for overall bleeding events at 1 year after percutaneous coronary intervention. The ARC HBR framework shows an overall good performance in both sexes, yet is lower in women than men, attributable to dichotomization of age, creatinine clearance, and hemoglobin values, which are differently distributed between sexes.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02241291.
“Impossible” Somatosensation and the (Ir)rationality of Perception
Authors: Won Isabel , Gross Steven , Firestone Chaz 
Published: June 2021

Abstract
Impossible figures represent the world in ways it cannot be. From the work of M. C. Escher to any popular perception textbook, such experiences show how some principles of mental processing can be so entrenched and inflexible as to produce absurd and even incoherent outcomes that could not occur in reality. Surprisingly, however, such impossible experiences are mostly limited to visual perception; are there “impossible figures” for other sensory modalities? Here, we import a known magic trick into the laboratory to report and investigate an impossible somatosensory experience—one that can be physically felt. We show that, even under full-cue conditions with objects that can be freely inspected, subjects can be made to experience a single object alone as feeling heavier than a group of objects that includes the single object as a member—an impossible and phenomenologically striking experience of weight. Moreover, we suggest that this phenomenon—a special case of the size-weight illusion—reflects a kind of “anti-Bayesian” perceptual updating that amplifies a challenge to rational models of perception and cognition. Impossibility can not only be seen, but also felt—and in ways that matter for accounts of (ir)rational mental processing.
Envoy Envy? Competition in African Mediation Processes and Ways to Overcome It
Authors: Lanz David 
Published: June 2021

Abstract
This article seeks to make sense of the dynamics of competition in African mediation processes and to outline approaches for effective cooperation between mediators. To this end, it analyzes four cases of recent peace processes: Sudan (1994–2005), Kenya (2008), Madagascar (2009–2013) and South Sudan (2013–2015). The article identifies four driving forces of competition among mediators: clashing interests of states involved in mediation, overlapping mediation mandates, incompatible norms guiding conflict resolution, and mediators’ lack of performance. These factors risk undermining peace processes unless the involved mediators and guarantors take active steps to mitigate the negative effects of competition. This can be done through ‘hierarchical coordination,’ where a recognized authority takes the lead and allocates roles to other actors, or through ‘collaborative cooperation,’ where partners have unity of purpose and decide on a division of labor based on comparative strengths.
Diagnostic value of susceptibility-weighted imaging for endometrioma: preliminary results from a retrospective analysis
Authors: Chen Hong , Wang Guoliang , Wang Xuexue , Gao Yan , Liang Junhua , Wang Jinhong 
Published: June 2021

Background Endometrioma is a common manifestation of endometriosis that can be difficult to diagnose with conventional magnetic resonance imaging (MRI). Susceptibility-weighted imaging (SWI) may be more sensitive than conventional MRI in the detection of chronic, local hemorrhagic disease. Purpose To investigate whether signal voids in SWI sequences could be used in the preoperative diagnosis of endometrioma. Material and Methods This retrospective study included consecutive female patients with clinically suspected endometrioma. All patients underwent pelvic 3-T MRI (T1- and T2-weighted) and SWI within two weeks before laparoscopy. Two experienced radiologists blinded to the histopathologic/clinical diagnoses interpreted the images together, and any disagreements were resolved by consensus. Results The final analysis included 73 patients: 46 patients (mean age=37 years; age range=22–68 years) with 85 endometrioma lesions and 27 patients (mean age=34 years; age range=15–68 years) with 34 non-endometrioid cystic lesions (18 hemorrhagic corpus luteal cysts, three simple cysts, three mucinous cystadenomas, two mature teratomas, and one endometrioid cyst with corpus luteum rupture/hemorrhage). The presenting symptoms for patients with endometrioma were chronic pelvic pain (44.6%), dysmenorrhea (31.9%), infertility (12.8%), dyspareunia (6.4%), and menstrual irregularity (4.3%). MRI identified all 119 lesions observed laparoscopically. SWI visualized punctate or curvilinear signal voids along the cyst wall or within the lesion in 67 of 85 endometriomas (78.8%) and only 3 of 31 non-endometrioid cysts (8.8%). Conclusion The use of SWI to look for signal voids in the cyst wall or within the lesion could facilitate the preoperative diagnosis of endometrioma.
Clinical Relevance of Persistent Off-Track Hill-Sachs Lesion After Arthroscopic Latarjet Procedure
Authors: Calvo Claudio , Calvo Javier , Rojas Daniel , Valencia María , Calvo Emilio 
Published: June 2021

Background: The Latarjet procedure is often used to address off-track Hill-Sachs lesions (OFF-HS) in shoulders with anterior instability. There are concerns as to whether the Latarjet procedure is able to convert all OFF-HS into on-track Hill-Sachs lesions (ON-HS) and whether this limitation could explain the cases of recurrent postoperative instability. Hypothesis: Latarjet surgery converts many preoperative OFF-HS lesions, but not all of them, and there is a difference in the failure rate between shoulders with converted lesions and those with persistent OFF-HS lesions. Study Design: Case series; Level of evidence, 4. Methods: Patients with anterior shoulder instability and an OFF-HS lesion treated with an arthroscopic classic Latarjet procedure between January 2010 and September 2017 were retrospectively evaluated. Patients with moderate or severe shoulder arthrosis, rotator cuff tears, or age older than 50 years were excluded. Glenoid track (GT), HS, HS interval (HSI), and the difference between HSI and GT (ΔHSI-GT) were measured preoperatively. A postoperative computed tomography scan and a clinical evaluation, including the Rowe and Western Ontario Shoulder Instability scores, were performed at a minimum 1- and 2-year follow-up, respectively. Postoperatively, 2 groups of patients were obtained: (1) patients with postoperative persistent OFF-HS; (2) patients with postoperative ON-HS. Clinical and imaging data were compared between the 2 groups. Results: A total of 51 patients (n = 51 shoulders), with a mean age of 29.8 ± 8.4 years (range, 15-50 years), met the inclusion criteria. Six shoulders (11.8%) still showed OFF-HS lesions despite Latarjet surgery. There were no postoperative dislocations, but 3 patients reported subluxations. The subluxation rate was significantly higher in the postoperative persistent OFF-HS group (2 [33%] vs 1 [2.2%]; P = .033). There was a wider preoperative HSI (29.8 ± 2.4 mm vs 22.9 ± 3.5 mm; P < .001) and a larger preoperative ΔHSI-GT (12.2 ± 3.8 mm vs 4.82 ± 3.2 mm; P < .001) in the persistent OFF-HS group. A receiver operating characteristic curve was performed based on preoperative ΔHSI-GT values. A preoperative ΔHSI-GT value ≥7.45 mm predicted a persistent OFF-HS after Latarjet surgery (sensitivity, 100%; specificity, 87%; positive predictive value, 50%; and negative predictive value, 100%). Conclusion: Latarjet surgery converted many preoperative OFF-HS lesions into ON-HS lesions, but not all of them. Six patients (11.8%) retained an OFF-HS and had a statistically significantly higher failure rate after Latarjet surgery compared with those with postoperative ON-HS lesions. Because there were few postoperative OFF-HS lesions and few recurrences, findings are statistically fragile and should be confirmed with larger series.