bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated seizure diagnosis system based on feature extraction and channel selection using EEG signals
Authors: Ein Shoka Athar A. , Alkinani Monagi H. , El-Sherbeny A. S. , El-Sayed Ayman , Dessouky Mohamed M. 
Published: February 2021

AbstractSeizure is an abnormal electrical activity of the brain. Neurologists can diagnose the seizure using several methods such as neurological examination, blood tests, computerized tomography (CT), magnetic resonance imaging (MRI) and electroencephalogram (EEG). Medical data, such as the EEG signal, usually includes a number of features and attributes that do not contains important information. This paper proposes an automatic seizure classification system based on extracting the most significant EEG features for seizure diagnosis. The proposed algorithm consists of five steps. The first step is the channel selection to minimize dimensionality by selecting the most affected channels using the variance parameter. The second step is the feature extraction to extract the most relevant features, 11 features, from the selected channels. The third step is to average the 11 features extracted from each channel. Next, the fourth step is the classification of the average features using the classification step. Finally, cross-validation and testing the proposed algorithm by dividing the dataset into training and testing sets. This paper presents a comparative study of seven classifiers. These classifiers were tested using two different methods: random case testing and continuous case testing. In the random case process, the KNN classifier had greater precision, specificity, positive predictability than the other classifiers. Still, the ensemble classifier had a higher sensitivity and a lower miss-rate (2.3%) than the other classifiers. For the continuous case test method, the ensemble classifier had higher metric parameters than the other classifiers. In addition, the ensemble classifier was able to detect all seizure cases without any mistake.
Pieces of evidences of reliability of the Brazilian version of the Child Executive Functions Battery (CEF-B)
Authors: Guerra Amanda , Hazin Izabel , Roulin Jean-Luc , Le Gall Didier , Roy Arnaud 
Published: February 2021

AbstractExecutive dysfunctions are central symptoms in different neurological, developmental, and context-related conditions. The assessment of these functions is then essential in neuropsychological pediatric clinical practice. Given the need for reliable and valid evaluation batteries for clinical practice in Brazil, this study aimed to present the pieces of evidences of reliability of the Child Executive Functions Battery (CEF-B). A total of 230 Brazilian children with typical development aged between 7 and 12 years participated in the study. Internal consistency was determined by the split-half method, Cronbach’s α, and Ω. In addition, measurements of test-retest reliability and intraclass coefficient were also performed. Retest indicators were mostly weak and moderate (between .43 and .75). Overvall, coefficients show a satisfactory internal consistency reliability for planning and inhibition measures (between .72 and .92). Considering the measures of WM, results were also satisfactory for both α and Ω indexes. This study revealed that the CEF-B has satisfactory internal consistency reliability coefficients. However, several tests have shown low reliability assessed through the test-retest method. In general, findings reveal interesting pieces of initial evidence of reliability of the Brazilian version. The methodological approach could be improved in future studies by including children with executive disorders.
Familial Short Stature—A Novel Phenotype of Growth Plate Collagenopathies
Authors: Plachy Lukas , Dusatkova Petra , Maratova Klara , Petruzelkova Lenka , Elblova Lenka , Kolouskova Stanislava , Snajderova Marta , Obermannova Barbora , Zemkova Dana , Sumnik Zdenek , Lebl Jan , Pruhova Stepanka 
Published: February 2021

Abstract

Context
Collagens are the most abundant proteins in the human body. In a growth plate, collagen types II, IX, X, and XI are present. Defects in collagen genes cause heterogeneous syndromic disorders frequently associated with short stature. Less is known about oligosymptomatic collagenopathies.

Objective
This work aims to evaluate the frequency of collagenopathies in familial short stature (FSS) children and to describe their phenotype, including growth hormone (GH) treatment response.

Methods
Eighty-seven FSS children (pretreatment height ≤ –2 SD both in the patient and his or her shorter parent) treated with GH were included in the study. Next-generation sequencing was performed to search for variants in the COL2A1, COL9A1, COL9A2, COL9A3, COL10A1, COL11A1, and COL11A2 genes. The results were evaluated using American College of Medical Genetics and Genomics guidelines. The GH treatment response of affected children was retrospectively evaluated.

Results
A likely pathogenic variant in the collagen gene was found in 10 of 87 (11.5%) children. Detailed examination described mild asymmetry with shorter limbs and mild bone dysplasia signs in 2 of 10 and 4 of 10 affected children, respectively. Their growth velocity improved from a median of 5.3 cm/year to 8.7 cm/year after 1 year of treatment. Their height improved from a median of –3.1 SD to –2.6 SD and to –2.2 SD after 1 and 3 years of therapy, respectively. The final height reached by 4 of 10 children differed by –0.67 to +1.0 SD and –0.45 to +0.5 SD compared to their pretreatment height and their affected untreated parent’s height, respectively.

Conclusion
Oligosymptomatic collagenopathies are a frequent cause of FSS. The short-term response to GH treatment is promising.
Fighting Fire With Fire: Oncolytic Virotherapy for Thoracic Malignancies
Authors: Ekeke Chigozirim N. , Russell Kira L. , Joubert Kyla , Bartlett David L. , Luketich James D. , Soloff Adam C. , Guo Zong Sheng , Lotze Michael T. , Dhupar Rajeev 
Published: February 2021

AbstractThoracic malignancies are associated with high mortality rates. Conventional therapy for many of the patients with thoracic malignancies is obviated by a high incidence of locoregional recurrence and distant metastasis. Fortunately, developments in immunotherapy provide effective strategies for both local and systemic treatments that have rapidly advanced during the last decade. One promising approach to cancer immunotherapy is to use oncolytic viruses, which have the advantages of relatively high tumor specificity, selective replication-mediated oncolysis, enhanced antigen presentation, and potential for delivery of immunogenic payloads such as cytokines, with subsequent elicitation of effective antitumor immunity. Several oncolytic viruses including adenovirus, coxsackievirus B3, herpes virus, measles virus, reovirus, and vaccinia virus have been developed and applied to thoracic cancers in preclinical murine studies and clinical trials. This review discusses the current state of oncolytic virotherapy in lung cancer, esophageal cancer, and metastatic malignant pleural effusions and considers its potential as an emergent therapeutic for these patients.
Octenidine dihydrochloride treatment of a meticillin-resistant Staphylococcus aureus biofilm-infected mouse wound
Authors: Huang Jianhua , Fan Qing , Guo Mingquan , Wu Minfeng , Wu Shutian , Shen Shuzhan , Wang Xiuli , Wang Hongwei 
Published: February 2021

Objective: This study sought to estimate the effect of a liquid octenidine dihydrochloride (OCT)-impregnated gauze dressing in the treatment of meticillin-resistant Staphylococcus aureus (MRSA) biofilm-infected wounds. Method: In this animal study, a six-millimetre punch full-thickness wound on each mouse back was inoculated with MRSA suspension, and then covered with a Tegaderm (3M Health Care, US) dressing for an established biofilm model. Animals were divided into three groups for topical application: control group (treated with phosphate-buffered saline, PBS); mupirocin group (treated with 2% mupirocin); and OCT group (treated with OCT). All applications were administrated once 24 hours post-wounding. The bioburden was determined by counting colony-forming units (cfus) and the biofilm architecture was viewed using fluorescent staining and scanning electron microscopy (SEM) on day two. The tissue repair was evaluated histologically and the related genes were detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR) on day 15. Results: The results suggested OCT accelerated healing and reduced by >3.6 log cfu/g bacterial counts on the wounds relative to the PBS-treated control (p<0.05). Histological analysis showed OCT-treated tissue exhibited lower burden of the inflammatory cells, more mature collagen fibres and well-defined epithelialisation. LIVE/DEAD fluorescent staining and SEM confirmed OCT induced a substantial destruction to biofilm structure. RT-qPCR further demonstrated that OCT therapy could inhibit the expression of MRSA and its biofilm genes by nearly 100% (p<0.05). Conclusion: This investigation provides a rare in vivo experimental basis for OCT improvement on MRSA-infected wound healing and the superior efficacy implies OCT topical application may represent an ideal choice to address established bacterial biofilm in hard-to-heal wounds.
Prevention of diabetic foot ulcers using a smartphone and mobile thermography: a case study
Authors: Oe Makoto , Tsuruoka Kahori , Ohashi Yumiko , Takehara Kimie , Noguchi Hiroshi , Mori Taketoshi , Yamauchi Toshimasa , Sanada Hiromi 
Published: February 2021

Objective: Early identification of pre-ulcerative pathology is important to preventing diabetic foot ulcers (DFU), but signs of inflammation are difficult to detect on the feet of patients with diabetic neuropathy due to decreased sensation. However, infrared thermography can objectively identify inflammation. Therefore, a device that allows patients to visualise thermograms of their feet might be an effective way to prevent DFU. We aimed to determine the effects of a novel self-monitoring device to prevent DFU using a thermograph attached to a smartphone. Method: A self-monitoring device comprising a mobile thermograph attached to a smartphone on a selfie stick was created, and its effects in two patients with diabetic neuropathy and foot calluses assessed. Results: For one patient, he understood that walking too much increased the temperature in the skin of his feet (a sign of inflammation). The other patient could not detect high-risk findings, because the temperature of his skin did not increase during the study period. Conclusion: This device might provide self-care incentives to prevent DFU, although some issues, such as the automatic detection of high-risk thermographic changes, need to be improved.
Time to closure of orthopaedic surgical incisions: a novel skin closure device versus conventional sutures
Authors: Gilat Ron , Haunschild Eric D , Tauro Tracy , Parvaresh Kevin C , Cole Brian J 
Published: February 2021

Objective: New technologies are being developed to optimise healing of surgical incisions. BandGrip (US) is a micro-anchor skin closure device that replaces the need for subcuticular suturing and further dressing. The purpose of this study is to perform a matched cohort analysis comparing time to closure of surgical incisions between sutures and the novel skin closure device. Method: Patients undergoing orthopaedic surgery in 2019 underwent skin closure with either conventional sutures or the novel skin closure device. Patients were divided into three groups according to their procedural incisions: anterior cruciate ligament reconstruction (ACLR); simple arthroscopy; and general incisions. Patients who underwent closure of their surgical incision with the novel skin closure device were matched with patients undergoing superficial closure with sutures. Statistical analysis was performed to compare time to closure per centimetre of skin incision between the groups. Results: A total of 86 patients were included in the study. Overall mean time to closure using the novel skin closure device was less than with sutures (8.6 seconds/cm versus 42.8 seconds/cm, respectively, p<0.001). Mean time to closure for ACLR incisions was 3.7 seconds/cm using the novel skin closure device and 35.5 seconds/cm using sutures (p<0.001). Mean time to closure for simple arthroscopy portals was 19 seconds/cm using the novel skin closure device and 47.6 seconds/cm using sutures (p<0.001). Conclusion: BandGrip is a novel skin closure device that allows for efficient surgical incision closure. Time to surgical skin incision closure is significantly less with the use of the novel skin closure device when compared with conventional sutures.
Disinfection capabilities of a 222 nm wavelength ultraviolet lighting device: a pilot study
Authors: Goh Jun Chance , Fisher Dale , Hing Eileen Chor Hoong , Hanjing Lee , Lin Yap Yan , Lim Jane , Chen Ong Wei , Chye Lim Thiam 
Published: February 2021

Objective: To demonstrate the efficacy of the SafeZone UVC (Ushio Inc., Japan) 222 nm ultraviolet C (UVC) light to reduce bacterial burden in pressure ulcers (PUs) in human patients. This research is the first human clinical trial using 222 nm UVC in eradicating bacteria in human wounds. Method: Patients with Stage 2 or 3 (as defined by the revised National Pressure Ulcer Advisory Panel Pressure Injury Staging System) sacral or gluteal pressure ulcers (PUs) were subjected to four sessions of 222 nm UVC light therapy over two weeks. Pre- and post-UVC therapy, wound cultures were taken and quantitative analysis of bacterial colony forming units (CFU) were performed. Results: A total of 68 UV light sessions across 16 different patients were conducted. Of these sessions, 59 (87.0%) sessions showed a reduction in CFU counts, with 20 (29.4%) showing complete eradication of bacteria. Bacteria identified included meticillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella Pneumoniae. The overall median reduction in CFU of the 68 sessions was 78.9%. No adverse events were reported in any of the UV sessions. Conclusion: In this study, 222 nm UVC light was safe and effective in reducing bacterial CFU counts in sacral and gluteal PUs across numerous different species of bacteria.
Day-case total hip arthroplasty: a literature review and development of a hospital pathway
Authors: Thompson Joshua W. , Wignadasan Warran , Ibrahim Mazin , Beasley Lucy , Konan Sujith , Plastow Ricci , Magan Ahmed , Haddad Fares S. 
Published: February 2021

Aims We present the development of a day-case total hip arthroplasty (THA) pathway in a UK National Health Service institution in conjunction with an extensive evidence-based summary of the interventions used to achieve successful day-case THA to which the protocol is founded upon. Methods We performed a prospective audit of day-case THA in our institution as we reinitiate our full capacity elective services. In parallel, we performed a review of the literature reporting complication or readmission rates at ≥ 30-day postoperative following day-case THA. Electronic searches were performed using four databases from the date of inception to November 2020. Relevant studies were identified, data extracted, and qualitative synthesis performed. Results Our evaluation and critique of the evidence-based literature identifies day-case THA to be safe, effective, and economical, benefiting both patients and healthcare systems alike. We further validate this with our institutional elective day surgery arthroplasty pathway (EDSAP) and report a small cohort of successful day-case THA cases as an example in the early stages of this practice in our unit. Conclusion Careful patient selection and education, adequate perioperative considerations, including multimodal analgesia, surgical technique and blood loss management protocols and appropriate postoperative pathways comprising reliable discharge criteria are essential for successful day-case THA. Cite this article: Bone Jt Open 2021;2(2):93–102.
Direct generation of sub-picosecond pulse via multi-section gain switching
Authors: Nakamura Takahiro , Ito Takashi , Nakamae Hidekazu , Kim Changsu , Hazama Yuji , Kobayashi Yohei , Kuroda Ryunosuke , Akiyama Hidefumi 
Published: February 2021

We have directly generated optical pulses having a duration of 0.56 ps
with a peak power of 25 W by gain switching of multi-section
semiconductor lasers in which the optimized lengths of the absorption
and gain regions were 50 and 200 µm, respectively. Even though the
experiment was conducted via impulsive optical pumping at a low
temperature, we observed that the multi-section gain switching
suppresses the low-energy tail and chirping inherent to conventional
gain switching in single-section lasers and is useful in direct
short-pulse generation.
Information transfer from the optical phase to a plasmonic digital encoder composed of a gold nanorod pair
Authors: Li Donghai , Wang Shufeng , Chu Saisai , He Yingbo , Lu Guowei , Jiang Hongbing , Gong Qihuang 
Published: February 2021

Small all-optical devices are central to the optical computing. Plasmonic digital encoders (PDEs) with a featured dimension of

∼

1

µ

m

hold the key for transferring information from far field to photonic processing systems. Here we propose a PDE design composed of two gold nanorods (AuNRs), whose pattern represents 2-bit digital information. We implanted information into the spectral phase of a femtosecond pulse by pulse shaping and controlled the two-photon photoluminescence pattern of an AuNR pair. The high contrast ratios were achieved with 13.01 and 6.02 dB for binary codes “1-0” and “0-1”, respectively.
Dry-etched ultrahigh-Q silica microdisk resonators on a silicon chip
Authors: Gu Jiaxin , Liu Jie , Bai Ziqi , Wang Han , Cheng Xinyu , Li Guanyu , Zhang Menghua , Li Xinxin , Shi Qi , Xiao Min , Jiang Xiaoshun 
Published: February 2021

We demonstrate the fabrication of ultrahigh quality (Q) factor silica microdisk resonators on a silicon chip by inductively coupled plasma (ICP) etching. We achieve a dry-etched optical microresonator with an intrinsic Q factor as high as

1.94
×

10

8

from a 1-mm-diameter silica microdisk with a thickness of 4 μm. Our work provides a chip-based microresonator platform operating in the ultrahigh-Q region that will be useful in nonlinear photonics such as Brillouin lasers and Kerr microcombs.
Delayed diagnosis of spinal cord schistosomiasis in a non-endemic country: A tertiary referral centre experience
Authors: de Wilton Angus , Aggarwal Dinesh , Jäger Hans Rolf , Manji Hadi , Chiodini Peter L. 
Published: February 2021

Background
Neuroschistosomiasis is a severe complication of schistosomiasis, triggered by the local immune reaction to egg deposition, with spinal cord involvement the most well recognised form. Early treatment with praziquantel and high dose steroids leads to a reduction of neurological sequelae. The rarity of this condition in returning travellers to high income countries can result in delayed diagnosis and treatment. We aimed to evaluate the diagnosis and management of neuroschistosomiasis in a UK national referral centre.

Materials/Methods
A retrospective review of confirmed clinical cases of spinal schistosomiasis referred to the Hospital for Tropical Diseases, UK, between January 2016 and January 2020 was undertaken. Electronic referral records were interrogated and patient demographic, clinical, laboratory, and radiological data collected.

Results
Four cases of neuroschistosomiasis were identified. The median age at diagnosis was 28 (range 21 to 50) with three male patients. All patients had epidemiological risk factors for schistosomiasis based on travel history and freshwater exposure; two in Uganda (River Nile), one in Malawi and one in Nigeria. All patients presented with features of transverse myelitis including back pain, leg weakness, paraesthesia and urinary dysfunction. The mean time from presentation to health services to definitive treatment was 42.5 days (range 16–74 days). Diagnosis was confirmed with CSF serology for schistosomiasis in all cases. Radiological features on MRI spine included enhancement focused predominantly in the lower thoracic spinal cord in three cases and the conus in one patient. All patients received a minimum of three days of oral praziquantel and high dose steroids. At three-month follow-up, one patient had complete resolution of symptoms and three had residual deficit; one patient was left with urinary and faecal incontinence, another had urinary retention, and the final patient has persistent leg pains and constipation.

Conclusion
We observed a marked delay in diagnosis of neuroschistosomiasis in a non-endemic country. We advocate undertaking a thorough travel history, early use of imaging and CSF schistosomal serology to ensure early diagnosis of neuroschistosomiasis in patients presenting with consistent symptoms. If schistosomal diagnostics are not immediately available, presumptive treatment under the guidance of a tropical medicine specialist should be considered to minimize the risk of residual disability. We advocate for consensus guidelines to be produced and reporting to be performed in a uniform way for patients with spinal schistosomiasis.
Direct antiviral agents for hepatitis C and drug interaction risk: A retrospective cohort study with real and simulated data on medication interaction, prevalence of comorbidities and comedications
Authors: Boff da Costa Raquel , Boff Costa Marisa , Longo Larisse , Miotto Daniela Elisa , Hirata Dellavia Gustavo , Trucollo Michalczuk Matheus , Reis Álvares-da-Silva Mario 
Published: February 2021

Introduction and aim
Comorbidities and comedication are common in patients with hepatitis C, which could result in a risk of drug-drug interaction. The objective of this study was to evaluate the prevalence of comorbidities, comedication and drug-drug interactions involving direct-acting antivirals in this population.

Methods
Comorbidities and comedications were evaluated in a retrospective cohort of hepatitis C patients. Drug-drug interactions were estimated in real life and with simulated data on comedications following drug regimens: telaprevir; elbasvir/grazoprevir, ombitasvir/paritaprevir/r/ritonavir (2D regimen), and sofosbuvir/simeprevir, sofosbuvir/daclatasvir, sofosbuvir/ledipasvir; 2D/dasabuvir (3D regimen); glecaprevir/pibrentasvir and sofosbuvir/velpatasvir/voxilaprevir. The interactions were evaluated according to the University of Liverpool database. Statistical analysis was performed by SPSS® 18.0.

Results
Data from 1433 patients with hepatitis C were evaluated. The mean patient age was 51.7 years (SD ± 10.7), and 50.6% were female. Direct-acting antivirals were prescribed for 345 (24.1%) patients, and a sustained virological response occurred in 264 (76.5%). The main comorbidities were systemic arterial hypertension [436 (30.4%)], diabetes mellitus [352 (24.6%)] and depression [130 (9.1%)]. The mean number of comorbidities was 1.52 (median [IQR] of 1.00 [1.00–2.00]). The mean number of comedications was 3.16 (median [IQR] of 3.00 [1.00–5.00]). A total of 12916 drug-drug interactions were found, of which 1.859 (14.4%) were high risk, with a mean of 1.29 ± 3.13 per patient. The 3D regimen, as well as glecaprevir/pibrentasvir and sofosbuvir/velpatasvir/voxilaprevir, presented the highest drug-drug interaction indexes.

Conclusion
Comorbidities and comedications are common in patients with hepatitis C, as are drug-drug interactions. Even when second generation drugs are used, the occurrence of drug-drug interactions still presents a significant risk.