bluuebunny/crossref_metadata_2025_split huggingface dataset:
What COVID‐19 taught us: New opportunities and pathways from telemedicine and novel antiseptics in wound healing
Authors: Scalise Alessandro , Falcone Marco , Avruscio Giampiero , Brocco Enrico , Ciacco Eugenio , Parodi Aurora , Tasinato Rolando , Ricci Elia 
Published: October 2021

AbstractThe COVID‐19 pandemic deeply impacted the capacity of the health systems to maintain preventive and curative services, especially for the most vulnerable populations. During the pandemic, the wound healing centres in Italy assisted a significant reduction of the frequency of their hospital admission, since only urgencies, such as severe infections or wound haemorrhagic complications, were allowed to the hospital. The aim of this multidisciplinary work is to highlight the importance of a new pathway of wound care with patient‐based therapeutic approach, tailored treatments based on the characteristics of the wound and fast tracks focused on the outpatient management, reserving hospital assessment only for patients with complicated or complex wounds. This analysis highlights the point that patients with chronic wounds need to be critically evaluated in order to find the best and most appropriate care pathway, which should vary according to the patient and, especially, to the characteristics of the wound. Moreover, the most adequate topic antiseptic should be started as soon as possible. An appropriate and correct management of the wound care will allow to link the knowledge based on years of clinical practice with the new challenges and the need to visit patients remotely, when possible.
Investigation into the phase structures and temperature stability of BiScO3‐PbTiO3‐based piezoelectric ceramics
Authors: Dong Yazhu , Zhou Zhiyong , Liang Ruihong , Dong Xianlin 
Published: October 2021

AbstractPhase structure has a strong influence on the temperature stability of ceramics; however, their influence on BiScO3‐xPbTiO3 has been neglected. To meet the requirements for practical applications, (0.98‐x)BiScO3‐xPbTiO3‐0.02Bi(Sn1/3Nb2/3)O3 (BS‐xPT‐BSN, 0.59 ≤ x ≤ 0.65) polycrystalline ferroelectrics with rhombohedral phase, morphotropic phase boundary (Cm and P4mm coexisting), and tetragonal phase has been prepared and studied. The relationship between the phase structures and temperature stability is established from the macro properties as well as the underlying domain behaviors. The results show that the tetragonal phase is not sensitive to temperature because of its stable domains, which is a positive motivator for improving the temperature stability of ceramics. This work provides a new strategy for the design of high‐temperature piezoelectric ceramics in the future.
Genomic analysis and characterization of Scenedesmus glucoliberatum PABB004: An unconventional sugar-secreting green alga
Authors: Calixto Mancipe Natalia , McLaughlin Evelyn M. , Barney Brett M. 
Published: October 2021

AbstractAimsIn this report, we present Scenedesmus glucoliberatum PABB004, a microalga that was isolated from an association with Paramecium bursaria with the potential for application in fermentative processes and co-culture schemes due to its advantageous high sugar secretion phenotype.Methods and ResultsWe sequenced, assembled and annotated the draft genome and transcriptome for this newly reported strain. The nuclear genome has an exceptionally high GC content of 78%. Our results revealed significant sugar accumulation over a range from 6.2 to 7.8 pH units. The predicted proteome was compared with other green algae that show different sugar secretion phenotypes aiming to help uncover their common features for simple sugar secretion and those unique to S. glucoliberatum PABB004.ConclusionsThe evolutionary history of this organism, inferred from its genomic traits, expands our current understanding of algal mutualistic relationships involving photosynthate exchanges. S. glucoliberatum PABB004 secreted ready-to-use fermentable sugars (glucose and maltose) directly to the extracellular media achieving concentrations greater than 2.7 g/L of free glucose and 1.2 g/L of maltose in batch cultures.Significance and Impact of the StudyA draft genome is provided for a new member of an important class of green algae. Scenedesmus glucoliberatum PABB004 secretes high levels of simple sugars over a broad pH range.
Novel colorimetric sensor array for Chinese rice wine evaluation based on color reactions of flavor compounds
Authors: Wang Yu , Huang Xing‐yi , Aheto Joshua , Ren Yi , Zhang Xiaorui , Wang Li 
Published: October 2021

AbstractIn this study, a 3 × 3 comprehensive colorimetric sensor array (CSA) was constructed for the quality evaluation of Chinese rice wine based on three different action principles (pH change principle, indicators displacement assay principle, and ethanol fading principle). First, China national standard was used to determine the total acid, reducing sugar, and alcoholic strength of six kinds of rice wine, which forms the basis for the selection of the CSA sensitive points. Then, CSA was combined with pattern recognition technologies to qualitatively distinguish rice wine. The results showed that the when PCs = 3, the linear discriminant analysis model can achieve a recognition rate of 100%, which shows strong prediction ability compared with K‐nearest neighbor and back‐propagation artificial neural network models. Finally, CSA was combined with partial least squares (PLS) and support vector regression (SVR) to quantitatively analyze the three components in rice wine. The correlation coefficients of the training set and predictions are more than 85% in the SVR model, which is superior to the PLS model. Based on these findings, it is possible to conclude that the CSA can be used to rapidly evaluate the quality of rice wine.Practical Applications
Established the 3 × 3 colorimetric sensor array (CSA) for the quality evaluation of Chinese rice wine based on three different action principles (pH change principle, indicators displacement assay principle, and ethanol fading principle).
The CSA was combined with pattern recognition technologies to qualitatively distinguish different kinds of rice wine. The performance of linear discriminant analysis shows strong prediction ability compared with K‐nearest neighbor and back‐propagation artificial neural network.
The CSA was combined with partial least squares (PLS) and support vector regression (SVR) to quantitatively analyze the three components in rice wine. The correlation coefficients of the training set and predictions are more than 85% in the SVR model, which is superior to the PLS model.
Skilled home healthcare clinicians' experiences in communicating with physicians: A national survey
Authors: Leff Bruce , Boyd Cynthia M. , Norton Jonathan D. , Arbaje Alicia I. , Pierotti Danielle M. , Carl Kimberly , Roth David L. , Nkodo Amelie , Nangunuri Bhavana , Sheehan Orla C. 
Published: October 2021

AbstractBackgroundEffective communication between skilled home healthcare (SHHC) clinicians and physicians is critical to care coordination. No studies have examined this from the point of view of SHHC clinicians at the national level. The objective is to determine in national sample issues related to how SHHC agency clinicians communicate with physicians.DesignMailed survey.MethodsMailed survey to a national representative random sample of SHHC agencies. The survey measured the experiences of SHHC clinicians in communicating with physicians. Multilevel logistic regression models examining odds of adverse patient outcomes associated with communication failures.ResultsA total of 265 surveys from 168 SHHC agencies were returned for a response rate of 13.3% at the individual respondent level and 16.8% at the SHHC agency level. Agency‐level characteristics were similar between responding and nonresponding agencies. The most common method of contacting physicians during routine SHHC visits was telephone; communication via the electronic health record was uncommon. Nearly 40% of SHHC clinicians report never or rarely being able to reach a physician. SHHC clinicians rate the Center for Medicare and Medicaid Services Home Health Certification and Plan of Care (CMS‐485) as a useful means of communication 6.3 (SD, 2.5) scale of 1 (least useful) to 10 (most useful); only 14% could have SHHC orders signed electronically. In multilevel logistic models, compared to SHHC clinicians who could reach a physician nearly every time or always, the odds of an SHHC clinician sending someone to the emergency department were 3.66 (95% confidence interval 1.16–11.5) for SHHC clinicians who were sometimes or often able to reach a physician and 5.43 (95% CI 1.56–18.9) for those who never or rarely reached a physician.ConclusionsIn this exploratory study, SHHC clinicians experience significant communication barriers with physicians who order SHHC services. Strategies to enhance meaningful communication between SHHC clinicians and physicians must be developed.
Seasonal changes in the physiological features of healthy and sensitive skin
Authors: Jiang Wencai , Wang Jing , Zhang Hui , Xu Yafei , Jiang Changqing , Yang Jingwen , Liu Wei , Tan Yimei 
Published: October 2021

AbstractBackgroundThe effects of seasonal factors on sensitive skin (SS) have been reported intensively, but the mechanisms still remain poorly understood.ObjectiveTo investigate the effects of seasonal factors on SS, by comparing the physiological changes in the healthy skin and different subgroups of SS with seasonal variation.MethodsThrough a questionnaire survey, lactic acid sting test, and capsaicin test, qualified subjects were classified into four groups: healthy skin, only lactic acid sting test positive (LAST(+)/CAT(−)), only capsaicin test positive (LAST(−)/CAT(+)), and both positive (LAST(+)/CAT(+)). Skin physiological parameters were measured in winter and summer.ResultsA total of 140 subjects completed the study. Significant differences were found in transepidermal water loss (TEWL), skin pH, and cutaneous blood flow (CBF) between winter and summer in the four groups. There were significant differences in stratum corneum hydration (SCH) of the LAST(+)/CAP(−) and LAST(+)/CAP(+) groups, current perception threshold (CPT) at 250 Hz of the LAST(+)/CAT(+) group, and epidermal density of the healthy skin group between the two seasons. Sum of the scores of sting (SSS) showed a close correlation with TEWL, SCH, pH, CPT at 250 Hz, and epidermal density. Sum of the scores of burning (SSB) showed a strong correlation with TEWL, pH, CPT at 250 Hz and 5 Hz, and epidermal density.ConclusionsSeasonal variation influences the skin barrier function of different types of sensitive skin at different levels. We therefore strongly suggest that, with seasonal variation, different treatments will be undertaken for different subgroups of sensitive skin.
Possible enigmatic link between serum leptin and vitiligo with its metabolic derangements: A comparative controlled study
Authors: El‐Hawary Marwa , El‐Tahlawi Samar , Ibrahim Sarah , El Ansary Mervat , Mogawer Rania M. 
Published: October 2021

AbstractObjectiveSerum leptin, an adipocytokine of interleukin‐6 family, has been linked to vitiligo‐associated metabolic derangements. Additionally, it has been proposed as an inflammatory mediator with possible influence on vitiligo pathogenesis. This study aimed at assessing serum leptin in vitiligo patients compared to controls and whether different vitiligo characteristics have an influence on serum leptin levels.MethodsIn this hospital‐based, cross‐sectional case‐control study, 70 vitiligo (35 segmental vitiligo (SV) and 35 Non‐segmental vitiligo (NSV)) and 70 age‐ and sex‐matched controls were assessed for different anthropometric measurements including waist circumference (WC), index of central obesity (ICO), and body mass index (BMI) as well as serum leptin levels.ResultsCentral obesity as per ICO showed no significant difference between patients and controls. Additionally, patients of SV and NSV collectively showed significant higher incidence of +ve serum leptin than their controls (41.4% vs. 22.9%%, P: 0.019). Mere presence of vitiligo and ICO >0.5 were highlighted as independent predictors of +ve serum leptin (P: 0.009 and <0.001, respectively).LimitationInability to determine a cause/effect relationship based on a cross‐sectional study. Larger scale studies are needed to affirm our findings.ConclusionMere presence of vitiligo being an independent predictor for high serum leptin could be either a contributor to pathogenesis of vitiligo or a sequel to accumulating evidence of metabolic nature of vitiligo. This is likely to influence the investigative panel and treatment protocol for vitiligo patients.
Complications of tattoos and permanent makeup: overview and analysis of 308 cases
Authors: van der Bent S.A.S. , Rauwerdink D. , Oyen E.M.M. , Maijer K.I. , Rustemeyer T. , Wolkerstorfer A. 
Published: October 2021

AbstractBackgroundWorldwide 10–20% of the population is tattooed. However, tattoo complications can occur, such as allergic tattoo reactions, infections, and manifestations of autoimmune dermatoses. Despite the growing popularity of tattoos and changes in tattoo ink composition over the last decades, little is known about these complications, its clinical aspects, pathomechanism, and relative occurrence.ObjectiveThe aim of this article is to describe the types and clinical aspects of dermatological tattoo complications, its relative occurrence and underlying conditions.MethodsWe performed a retrospective cohort study enrolling all patients with tattoo complications from the Tattoo Clinic. Tattoo complications were categorized into infections, inflammatory tattoo reactions, neoplasms, or miscellaneous reactions and correlated to clinical data.ResultsOf the total of 326 patients, 301 patients were included with 308 complications. The majority of the complications were chronic: 91.9%. Allergic red tattoo reactions and chronic inflammatory black tattoo reactions (CIBTR) accounted for 50.2% and 18.2%, respectively, of all tattoo complications. Of these CIBTR reactions, extracutaneous involvement was found in 21.4%, including tattoo‐associated uveitis (7.1%) and systemic sarcoidosis (14.2%). Of all black tattoo reactions, systemic sarcoidosis was found in 7.8%.ConclusionTattoos can cause a wide range in complications that may start years after getting the tattoo. The most frequent tattoo reactions are allergic red tattoo reactions and chronic inflammatory black tattoo reactions, making these the most relevant for the dermatologist. CIBTR have a high percentage of multi‐organ involvement, and therefore, screening for sarcoidosis, including ocular involvement, is advised.
Surgically confirmed adnexal torsion during pregnancy: Does the trimester make a difference?
Authors: Meller Nir , Levin Gabriel , Cohen Adiel , Abu‐Bandora Eiman , Amitai Komem Daphna , Mashiach Roy , Meyer Raanan 
Published: October 2021

AbstractAimTo investigate the clinical and the sonographic characteristics of adnexal torsion (AT) during pregnancy and to underline differences in AT manifestation between pregnancy trimesters.MethodsThis is a retrospective cohort study in a tertiary medical center. The study included all pregnant women with surgically confirmed AT between March 2011 and April 2020. The patients were divided into three groups according to pregnancy trimesters, and the clinical and sonographic characteristics were compared between the groups.ResultsThe study cohort included 140 cases of AT. Ninety‐nine (70.7%) of the cases occurred during the 1st trimester, and 31 (22.1%) and 10 (7.1%) occurred during the 2nd and the 3rd trimesters, respectively. Conception by assisted‐reproductive technologies (ART), nausea, and finding of enlarged ovary on ultrasound scan were all more common among patients in the 1st trimester group as compared to the 3rd trimester group (p = 0.001, 0.015, and 0.024, respectively). The mean time from admission to surgery was significantly shorter in the 1st trimester group as compared to late pregnancy (p = 0.001). The majority of cases were right‐sided. There was a significant difference in the organs involved in every trimester of pregnancy—ovary only, ovary and fallopian tube, and fallopian tube only (p = 0.023).ConclusionsMost AT cases during pregnancy occurred during the 1st trimester. Conception by ART and enlarged ovary on ultrasound scan were also more common in AT cases during early pregnancy. Time from admission to surgery was longer as pregnancy progressed and organs involved differed between trimesters. Understanding the difference in manifestation of AT in every trimester might improve the preoperative evaluation of AT in pregnancy.
Sleep during COVID‐19‐related school lockdown, a longitudinal study among high school students
Authors: Saxvig Ingvild West , Pallesen Ståle , Sivertsen Børge , Hysing Mari , Evanger Linn Nyjordet , Bjorvatn Bjørn 
Published: October 2021

SummaryThere has been great concern about the impact of coronavirus disease 2019 (COVID‐19)‐related school lockdown on adolescent health. The aim of the present study was to compare sleep patterns before and during COVID‐19‐related school lockdown, in a large sample of high school students. The present study is based a prospective, longitudinal survey on adolescent sleep health. Phase 1 was conducted in 2019, whereas phase 2 was conducted in 2020 (response rate 60.2%), during the last 10 days of a 60‐day long school lockdown. Main outcomes comprised sleep parameters from the Munich ChronoType Questionnaire (MCTQ). A total of 2,022 students provided valid responses to MCTQ in both survey phases. Results showed later sleep timing on schooldays in 2020 compared to 2019 (36 min later bedtimes, Cohen’s d = 0.56; 1:35 hr later rise times, Cohen’s d = 1.44). Time spent in bed on schooldays increased from 8:20 to 9:19 hr (Cohen’s d = 0.78), and sleep duration increased by 45 min (Cohen’s d = 0.49). The proportion of adolescents obtaining the recommended ≥8 hr of sleep on schooldays increased from 13.4% (2019) to 37.5% during the lockdown. Social jetlag was reduced from 2:37 hr (2019) to 1:53 hr (2020, Cohen’s d = 0.59). Results points to a potential advantageous effect of school lockdown in terms of increased school day sleep duration and reduced social jetlag. As sleep is important for mental and somatic health, it is conceivable that increased sleep duration offered some protection against harmful aspects of the COVID‐19 pandemic and associated social restrictions. Future studies should address possible associations between sleep changes and health during COVID‐19‐related school lockdown.
Quantitative Risk Assessments of Hepatitis A Virus and Hepatitis E Virus from Raw Oyster Consumption
Authors: Ruchusatsawat Kriangsak , Nuengjamnong Chackrit , Tawatsin Apiwat , Thiemsing Laddawan , Kawidam Chonthicha , Somboonna Naraporn , Nuanualsuwan Suphachai 
Published: October 2021

AbstractA quantitative risk assessment of hepatitis A virus (HAV) and hepatitis E virus (HEV) from raw oyster consumption from farm and retail was evaluated over three seasons. This risk assessment comprises four steps: hazard identification, dose–response assessment, exposure assessment, and risk characterization. We used probabilistic models for prevalence, concentration, and oyster consumption. HEV dose–response (DR) model based on HEV dosing in chimpanzees and used to perform a dose–response assessment of HEV was proposed. Both HAV and HEV were simultaneously enumerated by real‐time PCR to determine viral doses. The probabilistic prevalences of HAV and HEV were in the ranges of 8–20% and 8–40%, respectively. The best‐fit DR model was the beta‐Poisson with alpha and N50 equal to 216.9 and 3.03 × 107, respectively. After running the Monte Carlo simulation, the annual cases of foodborne hepatitis A and hepatitis E from raw oyster consumption from farms were 9,264–17,526 and 1–604, respectively, while those at retail were 7,694–14,591 and 1–204, respectively. This study suggested that consuming farm oysters poses a significantly higher risk of hepatitis A than hepatitis E. The best‐fit DR model for HEV developed in this study could determine risks of hepatitis E from raw oyster consumption in Thailand.
Spatial Risk Factors for Pillar 1 COVID‐19 Excess Cases and Mortality in Rural Eastern England, UK
Authors: Brainard Julii , Rushton Steve , Winters Tim , Hunter Paul R. 
Published: October 2021

AbstractUnderstanding is still developing about spatial risk factors for COVID‐19 infection or mortality. This is a secondary analysis of patient records in a confined area of eastern England, covering persons who tested positive for SARS‐CoV‐2 through end May 2020, including dates of death and residence area. We obtained residence area data on air quality, deprivation levels, care home bed capacity, age distribution, rurality, access to employment centers, and population density. We considered these covariates as risk factors for excess cases and excess deaths in the 28 days after confirmation of positive Covid status relative to the overall case load and death recorded for the study area as a whole. We used the conditional autoregressive Besag—York–Mollie model to investigate the spatial dependency of cases and deaths allowing for a Poisson error structure. Structural equation models were applied to clarify relationships between predictors and outcomes. Excess case counts or excess deaths were both predicted by the percentage of population age 65 years, care home bed capacity and less rurality: older population and more urban areas saw excess cases. Greater deprivation did not correlate with excess case counts but was significantly linked to higher mortality rates after infection. Neither excess cases nor excess deaths were predicted by population density, travel time to local employment centers, or air quality indicators. Only 66% of mortality was explained by locally high case counts. Higher deprivation clearly linked to higher COVID‐19 mortality separate from wider community prevalence and other spatial risk factors.
Slope, aspect, and hillshade algorithms for non‐square digital elevation models
Authors: Guth Peter , Kane Morgan 
Published: October 2021

AbstractCommon global digital elevation models (DEMs) at 1 to 3 arc‐second resolution use geographic coordinates for grid definition, and while cells are square (equal dx and dy spacing) near the equator, they become increasingly rectangular at higher latitudes. Some GIS software cannot handle rectangular grid cells, but minor modifications to slope, aspect, and hillshade algorithms can handle them. The algorithms can also handle grids with other projections, including Equi‐7, Lambert conformal conic, Lambert azimuthal equal area, and polar stereographic, converting aspect to true north instead of the potentially rotated grid. Computed slope varies with grid spacing with a logarithmic relationship and negative slope. Slope maps and distributions from rectangular DEMs, or DEMs where the actual grid spacing varies from the nominal values because points are far from the undistorted region, have characteristics equal to those of a Universal Transverse Mercator grid with spacing equal to the average dx and dy spacing of the DEM.