bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term effects of laparoscopic sleeve gastrectomy: What are the results beyond 10 years?
Authors: Kraljević M , Cordasco V , Schneider R , Peters T , Slawik M , Wölnerhanssen B , Peterli R 
Published: May 2021

Abstract

Objective
Sleeve gastrectomy (SG) has become the most commonly performed bariatric procedure worldwide. Newer studies providing long-term follow-up are showing high incidence of weight regain and high incidence of de novo reflux or worsening of preexisting GERD leading to conversion to different bariatric procedure. The objective of our study was to present 5 to 15-year follow-up results in terms of weight loss, remission of comorbidities and reoperation rate.

Methods
This is a retrospective analysis of prospectively collected data. The minimal follow-up time was 5 years. Patients who underwent SG between August 2004 and December 2014 were included. In case of reoperation patients were converted to Roux-en-Y gastric bypass or biliopancreatic diversion type duodenal-switch with or without hiatal hernia repair.

Results
A total of 307 patients underwent SG either as primary bariatric procedure (n = 262) or as redo operation after failed laparoscopic gastric banding (n = 45). Mean body mass index at time of primary SG was 46.4 ± 8.0 kg/m2. Mean age at operation was 43.7 ± 12.4 years with 68% females. Follow-up was 84% and 70% at 5 and 10 years respectively. The mean EBMIL for primary SG was 62.8 ± 23.1% after 5 years, 53.6 ± 24.6% after 10 years and 51.2 ± 20.3% after 13 years. Reoperation after SG was necessary in almost every fifth SG patient: 24 patients (7.8%) were reoperated due to insufficient weight loss, 12 patients (3.9 %) due to reflux, while 23 patients (7.5%) needed conversion due to both, insufficient weight loss and reflux. Comorbidities improved considerably while the incidence of new onset reflux was 29.7%.

Conclusion
SG provides a long-term EBMIL from 51 to 54% beyond 10 years and a significant improvement of comorbidities. On the other hand, a high incidence of both weight loss failure and de novo reflux was observed leading to conversion.
The spanning plate as an internal fixator in complex distal radius fractures – a prospective cohort study
Authors: Liechti R , Babst R , Hug U , Link B -C , van de Wall B , Knobe M , Beeres F 
Published: May 2021

Abstract

Objective
Minimal invasive temporary spanning plate (SP) fixation of the wrist has been described as an alternative treatment method in complex distal radius fractures (DRFs). The purpose of this study is to conduct an outcome analysis of all consecutive DRFs treated by SP fixation representing the so far largest published patient cohort outside the United States.

Methods
Indication for SP fixation included DRFs with severe metaphyseal comminution, radiocarpal luxation fractures with concomitant ligamentous injuries and very distal intra-articular fractures lacking the possibility of adequate plate anchoring. All consecutive patients undergoing SP fixation of DRFs were prospectively included in a single level I trauma centre between 01/01/2018 and 31/12/2020. Post-operative assessments included radiological, functional and patient-rated outcomes at a minimum of 12 months follow-up.

Results
In the mentioned timeframe, a total of 508 DRFs were treated operatively of which 28 underwent SP fixation. Average age was 58.1 years (range 22-95 years). The fracture type ranged from AO/OTA type B1.1 to C3.3 and included 8 fracture dislocations. SP removal was performed on average 3.7 months after the initial operation (range 1.4-6.5 months). The mean follow-up time was 14.5 months (range 12-24 months). Radiological evidence of fracture healing appeared on average 9.9 weeks (range 5-28 weeks) after the initial operation. One patient experienced oligosymptomatic non-union. Complications included 2 patients with tendon rupture and one patient with extensor tendon adhesions needing tenolysis at the time of plate removal leaving an overall complication rate of 12%. There was no implant failure and no infection. Mean satisfaction score was 8 (range 0-10) and mean visual analogue scale for resting pain was 0.9 (range 0-9). The mean PRWE score was 17.9 (range 0-59.5) and the mean DASH score was 16.6 (range 0-60.8). Grip strength averaged 23kg (range 4-74kg) amounting to 68% of the opposite side. Mean radial inclination, volar tilt and ulnar variance at 1 year were all within the acceptable limit predictive of symptomatic malunion.

Conclusion
The radiological, functional and patient-rated outcomes in this study are remarkably good considering the complexity of the included fractures. Therefore, this method represents a valuable alternative for the treatment of complex DRFs in selected patients.
Renal autotransplantation – reappraisal of an old technique
Authors: Akifi S , Gürke L , Wolff T 
Published: May 2021

Abstract

Objective
Transplantation of the patient’s own kidney into the iliac fossa has been described already more than 50 years ago, predominately for the treatment of renal trauma or peripheral renal artery aneurysms. The technique is however rarely used. We describe our experience with renal autotransplantation.

Methods
Retrospective analysis of consecutive patients.

Results
We performed renal autotransplantation in 3 patients from 2017-2019. The first patient was a 72y old male who had previously multiple stents placed in both renal arteries for renal artery stenosis and presented with a high grade in-stent stenosis of the right renal artery, complete occlusion of the left renal artery and left renal atrophy. The second patient was a 56y old male who presented with a 29mm aneurysm in the bifurcation of the left renal artery. The third patient was a 29y female with Takayasu disease, who had undergone endarterectomy of the abdominal aorta and vein bypass to the left renal artery as a child and stenting of the abdominal aorta for restenosis. She presented with aneurysmatic dilatation and high-grade restenosis of the vein bypass to the left renal artery. In the first two patients, laparoscopic nephrectomy via a retroperitoneal approach was performed as for living donor nephrectomy. The patient with the renal artery aneurysm had back table resection of the aneurysm and reconstruction by forming a common ostium of the two branch arteries. In the third patient, we explanted the kidney via laparotomy. In all patients, the kidney was perfused with cooled organ preservation solution after a brief period of warm ischemia and transplanted in the iliac fossa in standard fashion. After a median follow-up of 20 months (range 9-31) all autotransplanted kidneys showed good perfusion with no signs of renal artery stenosis. Median creatinine clearance was 97ml/min/1.7m2 (range 59-118).

Conclusion
Renal autotransplantation is a safe and durable procedure worth remembering when evaluating the treatment options of complex renal artery pathologies. Its use can also be envisaged for the treatment of complex renal trauma or complex ureter lesions.
In-hospital and mid-term outcome after complex endovascular aortic repair with fenestrated and branched stent-grafts
Authors: Makaloski V , Broger D , Weiss S , Jungi S , Becker D , Schmidli J 
Published: May 2021

Abstract

Objective
The aim of the study is to evaluate in-hospital and mid-term outcome after complex endovascular aortic repair with fenestrated and branched stent-grafts (fEVAR / bEVAR).

Methods
This is a single-center retrospective analysis from a prospectively collected database of all patients treated electively with fEVAR or bEVAR for para/suprarenal (PAA) and thoraco-abdominal aortic aneurysm (TAAA) between September 2010 and June 2019. In-hospital and mid-term mortality, major adverse events and re-interventions were assessed.

Results
Fifty-one patient (84% male) with a mean age of 74±7 years were analysed. Eighteen patients (35%) had TAAA, four patients (8%) suprarenal, and 29 patients (57%) pararenal aortic aneurysms. Mean aneurysm diameter was 64±8 mm. Thirty-eight patients (75%) underwent fEVAR and 13 patients (25%) bEVAR. A total of 157 target vessels were incorporated: 22 celiac trunks (CT), 40 superior mesenteric arteries (SMA), 92 renal arteries (RA), two separate hepatic arteries and one splenic artery. No in-hospital death or stroke was recorded. One patient suffered from early postoperative paraplegia and did not recover and one had paraparesis after 38 days and recovered completely. Six patients (12%) with patent renal arteries experienced acute postoperative kidney injury; one required temporary dialysis. Five in-hospital re-interventions were stent-graft related (four bridging stents angioplasty and one iliac leg extension) and seven re-interventions were not stent-graft related.
Mean follow-up was 19±17 months. Eleven patients (22%) died during follow-up: nine were not aortic-related and two were unknown. The Kaplan-Meier estimated survival rates at 1 and 2 years were 81% and 77%, respectively. Five renal stents (5%, 5/92) occluded during follow-up: three were successfully recanalized and two remained occluded. Ten stents (three CT, five SMA, and two RA stents required relining after 13±16 months postoperatively, resulting with estimated primary assisted patency at 2 years of 100%, 100%, 93%, and 95% for the CT, SMA, right RA and left RA, respectively.

Conclusion
Complex endovascular aortic repair with fEVAR / bEVAR for PAA and TAAA is safe with very low early mortality and morbidity. In-stent stenosis/occlusions occurred within the first two years. However, primary assisted patency was high. A surveillance program to detect potential stent-graft related complications is mandatory.
Early-cannulation arteriovenous grafts are safe and effective in avoiding recurrent tunneled central catheter infection
Authors: Richarz S , Stevenson K , White B , Thomson P , Jackson A , Isaak A , Kingsmore D 
Published: May 2021

Abstract

Objective
Tunneled central venous catheter infection (TCVCi) is a common complication that often necessitates removal of the TCVC and a further TCVC. Theoeretically, insertion of an early-cannualtion graft (ecAVG) early after TCVC infection is possible but not widely practiced with concerns over safety and infection in the ecAVG. With 8 years of ecAVG experience, the aim of this study was to compare the outcomes following TCVC infection, comparing replacement with TCVC (TCVCr) versus immediate ecAVG (ecAVGr).

Methods
Retrospective comparison of two cohorts, who underwent replacement of an infected TCVC either by an early cannulation graft (n = 18) or by a further central catheter (n = 39).
Data were abstracted from a prospectively completed electronic patient record and collected on patient demographics, TCVC insertion, duration and infection, including culture proven bacteriaemia and subsequent access interventions.

Results
18/299 patients identified from 2012-2020 had an ecAVG implanted as treatment for a TCVCi. In a one-year time-period (1/1/2015 -31/12/2015) out of 222 TCVC inserted, 39 were as a replacement following a TCVCi. No patient with an ecAVGr developed an immediate infection, nor complication from the procedure. The rate of subsequent vascular access infection was significantly more frequent for those with TCVCr than with an ecAVGr (0.6 vs. 0.1/patient/ 1000 HD days, p &lt; 0.000). The number of further TCVC required was significantly higher in the TCVCr group (7.1 vs. 0.4/patient/ 1000 HD days, p = 0.000).

Conclusion
An ecAVG early following a TCVC infection is safe, reduces the incidence of subsequent infectious complications and reduces the number of TCVC required, with a better functional patency.
Tele-proctoring in vascular surgery implementing percutaneous creation of arteriovenous fistula
Authors: Isaak A , Mallios A , Gürke L , Wolff T 
Published: May 2021

Abstract

Objective
Percutaneous ultrasound-guided creation of an arteriovenous fistula (pAVF) for hemodialysis access is a relatively novel procedure with promising technical success and patency rates. The vascular surgery departments of two collaborating Swiss hospitals had decided to introduce the technique to their services. A surgeon experienced in the technique (AM) was supposed to come to Switzerland and proctor the first four procedures. Due to the SARS-CoV-2 pandemic and travel restrictions, this was not possible and we decided to perform the first four pAVF procedures tele-proctored via a video conference system. We present the setup and our experience with tele-proctoring.

Methods
The setup relied on an all-in-one live video production device, video encoder, video streamer and video recorder (Pearl-2, Epiphan), which made it possible to simultaneously transmit the live image from the ultrasound device (GE Logiq S8, linear probe 9L-D) and a live image from a video camera (JVC Camcorder G/-HM440E, Japan), both connected via HDMI (Figure). The live stream was shared with the proctor in France and the device support team in the US, using an encrypted Swiss video client (www.vitimway.ch). The setup was tested with all parties three days in advance.

Results
All 4 procedures started with a verbal briefing and a live ultrasound scan. All steps of the procedures were taken under the proctor’s instruction and supervision. The proctor gave on average 21 instructions per procedure. An average 4 were device-related but these became less frequent as we proceeded. The operators consulted the proctor on average 5 times per procedure. The average duration of the procedure was 34 min. The pAVF creation was successful in all 4 patients, with an average fistula flow measured at the end of the procedure of 600 ml/min.

Conclusion
Our experience showed us that pAVF creation, which is a procedure performed entirely under sonographic guidance lends itself particularly well to tele-proctoring. The simultaneous transmission of the live sonographic image and the live image of the operators' hands allowed the proctor to supervise and correct the key steps of the procedures. The simplicity of the set-up and the quality of proctor-operator interaction was such a positive experience that we can well envisage a much wider use of tele-proctoring in the future.
First results of spatial reconstruction and quantification of COVID-19 chest CT infiltrates using lung CT analyzer and 3D slicer
Authors: Bumm R , Lasso A , Kawel-Böhm N , Wäckerlin A , Ludwig P , Furrer M 
Published: May 2021

Abstract

Objective
Lung CT scans are early diagnostic tests in evaluation of COVID-19 patients. Data are usually analyzed visually and the extent of infiltrations can only roughly be estimated. The aim of the present study was to create a software to spatially visualize and quantify infiltrated and collapsed areas in lung CT scans and set these volumes into relation with non-affected lung areas.

Methods
A new software "Lung CT Analyzer" (LCTA, 1) was created from scratch in an international team-effort within the 3D medical imaging software 3D Slicer (2). LCTA consists of two components: "Lung CT Segmenter" implements an intuitive and semiautomatic workflow for the generation of lung masks. LCTA then uses masked thresholds of Hounsfield units to detect non-affected versus affected (emphysematous, infiltrated, and collapsed) areas of the lung. Intrapulmonary vessels are subtracted from the other volumes. Segment volumes are expressed in milliliters and displayed in 3D. COVID-Q was defined as affected divided by non-affected volume and can be calculated separately for both lungs.
3D Slicer and LCTA are open source, freely available and maintained on Github.

Results
CT data of twelve patients with moderate to severe COVID-19 (9 m, 3 f) were selected for the present retrospective study. All scans were performed shortly after admission. Thresholds of Hounsfield units (HU) for areas of interest were defined prior to the study and processing was identical for all patients. The median time effort for 3D reconstruction was 8 minutes per patient. For more detailed results please see the enclosed table. A 3D Slicer demo data set (Control) has been included for comparison.

Conclusion
The COVID-19 pandemic promoted fast-paced innovations such as LCTA in our hospital. LCTA was feasible, reproducible and easy to perform. COVID-Q correlated with COVID-19 lung involvement in all cases. All fatal cases showed COVID-Q values of &gt; 2.0.
LCTA enabled the serial 3D reconstruction of infiltrated and collapsed lung areas in lung CT scans. The procedure may be of great help in the future analysis of pulmonary infiltrates of any cause. In COVID-19 disease, volumetric lung CT reconstruction could result in the definition of new prognostic factors, identify patients “at-risk” in the ICU, and be useful for follow-up.
(1) Lung CT Analyzer: https://github.com/rbumm/SlicerLungCTAnalyzer
(2) 3D Slicer: http://slicer.org
Nationwide study on stress perception among surgical residents
Authors: Guglielmetti L C , Gingert C , Holtz A , Westkämper R , Lange J , Adamina M 
Published: May 2021

Abstract

Objective
Declining number of applicants and high attrition of residents are a dire reality. Surgeons in training are confronted to various stressors which interfere with their performance and may promote burnout. This study measures stress levels of Swiss surgical residents while considering age, gender, specialty, position, native language, and experience.

Methods
Swiss surgery residents taking the Surgical Basic Exam from 2016 to 2020 completed the Perceived Stress Scale 10 (PSS). The PSS measures how unpredictable, uncontrollable, and overloaded respondents evaluate their work life. Scores up to 13 are normal and scores around 20 are highly pathologic. High subscores of helplessness (PH) and lower subscores of self-efficay (PSE) indicate distress.

Results
1694 questionnaires were evaluated (return rate 95.7%). Resident median (m) age was 29 years, 56.5% were male and 43.5% female. 72.7% of the residents were in their first 2 years of training, aiming for orthopedic (24%), general surgery (23.8%), urology (6%), or plastic surgery (5.6%). Residents reported a high PSS (m = 15), a high PH (m = 9), and an ordinary PSE (m = 5). Females reported worse PSS (p &lt; 0.001), PH (p &lt; 0.001), and PSE (p = 0.036) than males. Visceral and orthopedic surgeons had significantly better PSS, PH, and PSE.
In multivariable analysis, male sex (p &lt; 0.001), aiming at orthopedic (p = 0.017) or visceral surgery (p = 0.004), and French as a mother tongue (p = 0.037) predicted lower stress levels, while graduating from a country not adjacent to Switzerland led to higher stress (p = 0.047). Similarly, male sex (p &lt; 0.001), visceral surgery (p = 0.032), French mother tongue (p = 0.018), and more than 5 years in training independently predicted lower PH. Last, PSE was not influenced by gender, while residents in training for orthopedic (p = 0.004), visceral (p = 0.007) and urology (p = 0.014) specialities, as well as Italian native speakers (p = 0.017) reported less PSE.

Conclusion
Perceived stress levels are high in both genders in this large, prospective and representative cohort study of Swiss surgical residents. Females endured significantly worse stress and helplessness levels than males. These figures are worrisome as they may directly contribute to the declining attractivity of surgical residencies. Detailed and gender specific analysis of stressors during residency are urgently needed to improve residency programs.
Surgical skill assessment using machine learning algorithms
Authors: Lavanchy J L , Zindel J , Kirtac K , Twick I , Hosgor E , Candinas D , Beldi G 
Published: May 2021

Abstract

Objective
Surgical skill is correlated with clinical outcomes. Therefore, the assessment of surgical skill is of major importance to improve clinical outcomes and increase patient safety. However, surgical skill assessment often lacks objectivity and reproducibility. Furthermore, it is time-consuming and expensive. Therefore, we developed an automated surgical skill assessment using machine learning algorithms.

Methods
Surgical skills were assessed in videos of laparoscopic cholecystectomy using a three-step machine learning algorithm. First, a three-dimensional convolutional neural network was trained to localize and classify the instruments within the videos. Second, movement patterns of the instruments were recorded over time and extracted. Third, the movement patterns were correlated with human surgical skill ratings using a linear regression model to predict surgical skill ratings automatically. Machine ratings were compared against human ratings of four board certified surgeons using a score ranging from 1 (poor skills) to 5 (excellent skills).

Results
Human raters and machine learning algorithms assessed surgical skills in 242 videos. Inter-rater reliability for human raters was excellent (79%, 95%CI 72-85%). Instrument detection showed an average precision of 78% and average recall of 82%. Machine learning algorithms showed an 87% accuracy in predicting good or poor surgical skills, when compared to human raters.

Conclusion
Machine learning algorithms can be trained to distinguish good and poor surgical skills with high accuracy.
This work was published in Sci Rep 11, 5197 (2021). https://doi.org/10.1038/s41598-021-84295-6
Metabolic activity by FDG-PET/CT after neoadjuvant chemotherapy in borderline resectable and locally advanced pancreatic cancer and association with survival
Authors: Lee Woohyung , Oh Minyoung , Kim Jae Seung , Park Yejong , Kwon Jae Woo , Jun Eunsung , Song Ki Byung , Lee Jae Hoon , Hwang Dae Wook , Yoo Changhoon , Kim Kyu-Pyo , Jeong Jae Ho , Chang Heung-Moon , Ryoo Baek-Yeol , Park Seo Young , Kim Song Cheol 
Published: May 2021

Abstract

Background
The optimal prognostic markers for neoadjuvant chemotherapy in patients with borderline resectable or locally advanced pancreatic cancer are not yet established.

Method
Patients who received neoadjuvant chemotherapy prior to surgery and underwent FDG-PET/CT between July 2012 and December 2017 were included. Metabolic parameters including standardized uptake value (SUV), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) on PET/CT, and response evaluations using PERCIST criteria, were investigated for its impact on survival and recurrence. Cox proportional hazards model was performed. Differences in risk were expressed as hazard ratio (HR) with 95 per cent confidence interval.

Results
The patients with borderline resectable (N = 106) or locally advanced pancreatic cancer (N = 82) were identified. The median survival was 33.6 months. Decreased metabolic parameters of PET/CT after neoadjuvant chemotherapy were associated with positive impacts on survival and recurrence such as SUVmax (HR 1.16, 95 per cent c.i. 1.01 to 1.32, P = 0.025), SUVpeak (HR 1.26, 95 per cent c.i. 1.05 to 1.51, P = 0.011), and MTV (HR 1.15, 95 per cent c.i. 1.04 to 1.26, P = 0.005). Large delta values were related to a positive impact on recurrence such as SUVmax (HR 1.21, 95 per cent c.i. 1.06 to 1.38, P = 0.005). Post-neoadjuvant chemotherapy SUVmax ≥3 (HR 3.46, 95 per cent c.i. 1.21 to 9.91; P = 0.036) was an independent prognostic factor for negative impact on survival. Patients with post-neoadjuvant chemotherapy SUVmax &lt;3 showed more chemotherapy cycles (8.7 versus 6.2, P = 0.001), more frequent complete metabolic response (25 versus 2.2 per cent, P = 0.002), smaller tumour size (2.1 versus 3.1 cm, P = 0.002), and less frequent lymphovascular invasion (23.7 versus 51.1 per cent, P = 0.020) than patients with SUVmax ≥3.

Conclusion
Reduction in metabolic tumour parameters of FDG- PET/CT after neoadjuvant chemotherapy indicates improved overall survival and recurrence-free survival.