bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competitive-Blockchain-Based Parking System with Fairness Constraints
Authors: Balzano Walter , Pegna Marco La , Stranieri Silvia , Vitale Fabio 
Published: June 2021

Abstract
Parking slot detection is one of the most popular applications of Vehicular ad Hoc Network re-search field. Proposing smart algorithms for fast parking is crucial not only to facilitate drivers, but also to reduce traffic congestion, pollution, and vehicle energy consumption. Typically, an urban area has several competitive car parks and, in order to make the parking process automatic, a mechanism to ensure a fair competition among them is needed. Among all the methods able to guarantee transparency and equity in a system, blockchain is a robust technology. It has been success- fully applied in many different research fields, from financial to health. In this work, we provide an automaticparking system in which vehicles are allocated among several competitive parking areas (called competitors), through a blockchain-based approach, by applying a consensus mechanism to manage the system modifications. To this aim, two classes of fairness constraints are defined, according to which any new operation on the parking consortium must be approved by the members. Such an approach brings benefits for different reasons, starting from traffic condition improvement, up to driver stress and pollution decrease.
Patient Participation In Surgical Upper Abdominal Cancer Care: Assessment of The Alignment Between Patients’ Preferences And Experiences With The Patient Preferences For Patient Participation (4Ps) Tool
Authors: Drott Jenny , Fomichov Victoria , Nordén Maria , Larsson Anna Lindhoff , Sandström Per , Björnsson Bergthor , Eldh Ann Catrine 
Published: June 2021

Abstract
PurposeQuality healthcare necessitates opportunities for patient participation. The study aim was to investigate the level of preference-based patient participation in surgical upper abdominal cancer care based on patients’ reports of their preferences and experiences of patient participation.MethodsA cross-sectional design was used, and patients completed the Patient Preferences for Patient Participation (4P) tool after hospital discharge. Patient ratings of the 12 attributes of the 4Ps in terms of their preferences for and experiences of patient participation were analysed with descriptive and comparative statistical methods.ResultsThe 101 respondents often reported sufficient levels of preference-based patient participation. Having reciprocal communication and being listened to by healthcare staff were commonly deemed crucial for participation. Furthermore, 60% of the patients suggested that taking part in planning was crucial for their participation, but they experienced this attribute only to some extent.ConclusionTo support person-centred participation, further efforts are needed to recognize patients’ preferences for involvement; opportunities to share experiences and share in planning healthcare activities are important for patients in surgical upper abdominal cancer care. Probing and recognizing patients’ preferences and experiences makes it easier to tailor patient participation to the individual patient, supporting more holistic surgical cancer care.
Unique Clinical Features of Hereditary Gingival Fibromatosis Withelevated Expression of Human β-Defensin-2 and -3 in Gingival Epithelia
Authors: Gao Ge , Tian qing , Han Peng An , Yang Xia Rong , Shi Fan , Chen Dong 
Published: June 2021

Abstract
Background: Hereditary gingival fibromatosis (HGF), a rare benign oral condition, has several adverse consequences such as aesthetic changes, malocclusion, speech impediments, and abnormal dentition . H owever, relatively few studies have addressed the beneficial effects of thick gingival tissues on resisting external stimuli. Patients with HGF commonly manifest a ‘healthy’ gingiva , and the aetiology and pathogenesis of this condition remain unclear. H uman β-defensins (hBDs) are known to play a pivotal role in the clearance and killing of various microbes and contribute to maintaining a harmonious oral environment, which is currently an emerg ing research focus. We previously performed an immunohistochemi cal analysis of gingival tissues from a multigenerational family with non-syndromic HGFs (NHGF) . However , the expression pattern and localisation of hBD-2 and - 3 in patients with NHGF has not been reported. Methods: Gingival tissue was paraffin embedding, sectioned, and then the expression and localisation of hBD-2 and -3 in the gingival epithelium of patients with HGF and normal individuals were compared using immunohistochemistry (IHC) with descriptive and quantitative analysis. Results: The immunohistochemical staining showed a statistically significant increase in hBD-2 and 3 in gingiva l tissue derived from patients with HGF. Conclusion: Our current findings provide evidence to support the novel hypothesis that certain gene mutations of the HGF lead to relatively elevated expression levels of hBDs, which may be beneficial in protect ing oral tissue from external stimuli and promot ing periodontal regeneration.
Modeling D2D Underlaying Cellular Network for Hotspot Communications with Poisson Cluster and Hole Processes
Authors: jia xiangdong , wei Zhemin , Hao Zhenchao , Ouyang Yuhua 
Published: June 2021

Abstract
This paper develops a new approach to the modeling and analysis of device-to-device (D2D) underlaying multi-tier cellular network for the dense hotspot communications, which consist of macro base stations (MBSs), pico BSs (PBSs), femto BSs (FBSs). A typicl user equipment (UE) can work either in D2D mode or cellular mode. Considering the dense hotspot communications, this work employs Poisson point process (PPP) to model the locations of MBSs and PBSs, and uses Poisson cluster process (PCP) to model the ones of UEs and FBSs. The locations of PBSs are also modeled as the centers of hotspots, referred to as the centers of PCPs. UEs and FBSs cluster around the common parent process PBSs. To guard the cluster-edge UEs, the clustered-UE classification and modified fractional frequency reuse (FFR) are jointly used, by which both the UEs and FBSs are classified two sets, cluster-center UEs and cluster-edge UEs, cluster-center FBSs and cluster-edge FBSs, respectively. The total frequency band is divided into two orthogonal segments, one of which is shared by D2D devices, cluster-edge FBSs, and PBSs, and the other segment is shared by cluster-center FBSs and MBSs. For such clustered multi-tier network, by using the methods from PPP, PCP, and PHP, this paper presents a tractable approach for modeling and analyzing the performance of cellular and D2D networks and gives the statistical descriptions of the experienced interference at a typical receiver by using the approximated Poisson hole processes (PCP) theory. This yields the derivations of the coverage probabilities of both the D2D receivers and cellular destinations. In additon, during the analysis of cellular UEs, to derive the coverage probabilities, this paper specially constructs a UE association criterion as well as the derivations of both the association probabilities and the statistical descriptions of association distances for cluster-center and cluster-edge UEs. The simulations and numerical results exploit the effect of various network parameters on the network performance and give the insights in terms of the proposed schemes as well as the comparison between cluster-center and cluster-edge UEs.
When Technology Enters at Home: The Challenges of Home Health Care Providers in a Developing Country
Authors: Esmaeili Maryam , nayeri Nahid Dehghan , Bahramnezhad Fatemeh , Ghazi Samrand Fattah , Asgari Parvaneh 
Published: June 2021

Abstract
Background: The number of patients with chronic diseases requiring invasive mechanical ventilation at home is increasing. Family caregiving for patients with home mechanical ventilation (HMV) is associated with a particularly heavy workload. Thus, identifying the challenges of this valuable type of care can be an elective step for achieving health-related goals. This study was carried out to determine the challenges faced by home health care providers.Methods: 15 participants (9 family caregivers, 3 home nurses, and 3 home care attendants) were selected. Data were collected through semi-structured interviews and structured observation. All the interviews were recorded, transcribed, and then analyzed using qualitative content analysis and Max Qualitative Data Analysis 2010.Results: Three themes emerged from the data analysis: (1) Hospital-based challenges with two subthemes the family unpreparedness for home care and the lack of continuous education, (2) Home health care agency challenges with two sub themes. Home health care workers and the deficiency in organizational policies, and (3) Economic challenges.Conclusions: Three themes of hospital-related challenges, home health care agency challenges, and economic challenges emerged in the study showed that support from the insurance system, improvement of home care agency policies, and holistic care for patients through a multidisciplinary team approach are essential for addressing the current challenges of home care for patients under invasive mechanical ventilation at home.
Validation of the Dutch version of the Chemotherpy-induced Taste Alteration Scale (CiTAS)
Authors: Corremans Marleen , Geurden Bart , Luyten Sarah , Mortelmans Dimitri 
Published: June 2021

Abstract
Purpose: Taste and smell alterations are known side-effects of an oncological treatment with chemotherapy and can cause reduced food intake and lead to malnutrition and cachexia. ESPEN guidelines state that organizations should foresee a protocol to identify patients at nutritional risk and that screening should be available for all patients. The Chemotherapy-induced Taste alteration Scale (CiTAS) is described as a self -reported scale with a high reliability and validity. The aim of this study is to make a back translation and validation of the Chemotherapy-Induced Taste Alteration Scale in Dutch.Methods: The evaluation instrument was constructed in a three-phased project. First, the Japanese version was backtranslated to Dutch and piloted in a cognitive interview. In a second phase, a Delphi procedure was followed. Context validity and Cronbach’s alpha were calculated. In a third phase comfirmatory analysis was tested.Results and conclusion: The overall Cronbach’s alpha was 0.89. The convergent and discriminant validity show us that the items that should be related indeed are, like the items in the construct and that items that shouldn’t, are not, as between the constructs. The scale was successfully backward translated and validated in Dutch and is ready to be used to screen Dutch speaking cancer patients with chemotherapy as a treatment for their cancer diagnosis. This version of CiTAS can be implemented in the Flemish speaking part of Belgium and in the Netherlands.
Target-Adverse Events and Fear of Cancer Progression, Anxiety, and Depression in Patients with Advanced Non-Small Cell Lung Cancer
Authors: Yu Chu Chun , Chu Chia Yu , Lai Yeur Hur , Chan Jui Chun , Chen Yen Ju , Hsu Hui Te , Lee Yun-Hsiang 
Published: June 2021

Abstract
Objective: To examine the difference in levels of fear of cancer progression (FoP), anxiety, depression between presence/absence of the target-adverse events (AEs); and to examine the differences in incidence rate of AEs and FoP, anxiety, and depression among three generations of EGFR-TKIs therapy (first, gefitinib and erlotinib [G1]; second, afatinib [G2]; third, osimertinib [G3]) in non-small-cell lung cancer (NSCLC) patients.Methods: A cross-sectional study design. NSCLC patients (n=128) were recruited from a medical center in Taiwan. A set of structured questionnaires assessing AEs, FoP, anxiety and depression. Results: Parts of AEs, such as photosensitivity, paronychia, and alopecia, exhibited significantly higher levels of FoP, anxiety, and depression. Less patients experienced AEs in the G3 group than those in the G1 or G2 group but still reported experiencing itching, dry skin with grade 3 severity. The incidence rates of mouth/throat sores, and cheilosis/cheilitis in the G2 group was significantly higher than those in the G1 or G3 group. The incidence rate of FoP, anxiety and depression were 13.8-26.3%, 23.8-40.4% and 16.7-42.1%, respectively.Conclusions: The priorities of care among three generations of EGFR-TKIs in patients with NSCLC were established. FoP, anxiety and depression were present among different targeted therapies and require further attention.
The Improved TBW Versus the Standard TBW for Olecranon Fractures in the Aged: a Retrospectively Comparative Study
Authors: Lin Xiaoyong , Liao Hai 
Published: June 2021

Abstract
Objectivession: Olecranon fractures of the aged are traditionally managed operatively with Tension Band Wire (TBW). We compared clinical outcomes of treatment of the improved TBW versus the standard TBW for the treatment of the senile Olecranon fractures patients. Methods: A retrospective study was conducted on senile olecranon fractures patients in our hospital from June 2016 to January 2019. After appropriate exclusion, 62 olecranon fractures patients (29 patients in group A of the improved TBW, 33 patients in group B of the standard TBW) were reviewed in this study. All reviewed patients underwent preoperative immobilization and detumescence, open reduction and internal fixation, and postoperative function exercise. Duration of surgery, intraoperative blood loss, times of fluoroscopy intraoperatively, postoperative pain score, fracture union time, soft tissue irritation, failure of fixation and Broberg Morrey score of elbow function were recorded and compared.Results: The duration of surgery, intraoperative blood loss, postoperative pain score, Broberg Morrey score of elbow function had no significant difference between the two groups. The improved TBW (group A) was better than the standard (group B) in terms of the fixation loosening, fracture union time, the skin irritation, and the difference was significant ( all p< 0.05) .Conclusions: On the basis of no additional surgical trauma, the improved TBW was not only benefit for the fracture union, but also benefit for reducing the incidence of internal fixation loosening and soft tissue irritation. This improved internal fixation is not an unattractive option for senile olecranon fractures patients.
A Chebyshev Polynomial-Based Conditional Privacy-Preserving Authentication and Group-Key Agreement Scheme for VANET
Authors: Yang Jiyun , Deng Jiamin , Xiang Tao , Tang Bo 
Published: June 2021

Abstract
Vehicle ad hoc network (VANET) is an open communication environment. Any user can broadcast messages, which means that it can be easily attacked by malicious users. Therefore, the authentication of vehicles is needed. In this paper, we propose a Chebyshev polynomial-based conditional privacy-preserving authentication and group-key agreement scheme for VANET. Specifically, we solve three problems in VANET: (1) we improve the effectiveness of TA by using Chebyshev polynomial to authenticate vehicles; (2) we reduce the computational burden of TA by using Chinese remainder theorem to manage group members; (3) we provide conditional privacy for users by using traceable pseudonym scheme. Theoretical and experimental results show that the proposed scheme is more efficient than existing related work.
Targeting Histone Deacetylase-3 Blocked Epithelial-Mesenchymal Plasticity And Metastatic Dissemination In Gastric Cancer
Authors: Wu Sheng-Mao , Jan Yee-Jee , Tsai Shih-Chuan , Pan Hung-Chuan , Shen Chin-Chang , Yang Cheng-Ning , Lee Shu-Hua , Liu Shing-Hwa , Chiu Chien-Shan , Arbiser Jack L. , Meng Menghsiao , Sheu Meei-Ling 
Published: June 2021

Abstract
Background and purpose: Histone deacetylase (HDAC) inhibitors (HDIs) were shown to modulate the epithelial-mesenchymal transition (EMT) progression and inhibit the migration and invasion of cancer cells. Emerging as a novel class of anti-cancer drugs, HDIs have attracted much attention in the field of drug discovery. This study aimed to the underlying mechanisms of Honokiol in preventing the metastatic dissemination of gastric cancer cells by inhibiting HDAC3 activity/expression.Experimental Approach: Clinical pathological analysis was performed to determine the relationship between HDAC3 and tumor progression. The effects of Honokiol on pharmacological characterization, functional, transcriptional activities, organelle structure changes, and molecular signalings were analyzed using binding assays, Differential Scanning Calorimetry, luciferase reporter assay, HDAC3 activity, ER stress response element activity, transmission electron microscopy, immune-blotting and Wnt/b-catenin activity assays. The in vivo effects of Honokiol on peritoneal dissemination were determined by a mouse model and detected by the PET/CT tomography.Key Results: HDAC3 over-expression was correlated with poor prognosis. Honokiol significantly abolished HDAC3 activity (Y298) via inhibition of NFκBp65/CEBPb signaling, which was reversed by the over-expression of plasmids of NFκBp65/CEBPb. Honokiol-inhibited NFκBp65/CEBPb activation could be reversed by 4-phenylbutyric acid (a chemical chaperone) and calpain-2 gene silencing. Honokiol increased ER stress markers and inhibited EMT-associated epithelial markers, but decreased Wnt/β-catenin activity. Suppression of HDAC3 by both Honokiol and HDAC3 gene silencing decreased cell migration and invasion in vitro and metastasis in vivo. Conclusions and Implications: Honokiol acts by suppressing HDAC3-mediated EMT and metastatic signaling. By prohibiting HDAC3, metastatic dissemination of gastric cancer may be blocked.
Landscape-Level And Stand-Level Factors Play Diverse Roles During Different Periods of Dendroctonus Valens Invasion In North China
Authors: Zhan Zhongyi , Ren Lili , Yu Linfeng , Guo Zhiwen , Liu Yujie , Li Haonan , Wang Lixia , Luo Youqing 
Published: June 2021

Abstract
In recent years, the red turpentine beetle (RTB), an invasive pest species, has caused extensive pine mortality in North China. Although some studies have theoretically clarified the interference mechanism of multi-level factors with the development of RTB damage, knowledge about this mechanism from the empirical research is still limited. The aim of this study was to determine whether the primary factors influencing RTB occurrence change during different periods of RTB invasion. Stand-level variables of sample plots were obtained through field investigation and the forest resource survey data including forest stand characteristics, topographic characteristics, and soil properties. Remote sensing classified images were to develop the characteristic variables related to landscape composition and configuration around the sample plots at multiple scales. Generalized linear models (GLMs) and generalized linear mixed models (GLMMs) were used to explore the relative importance of stand-level and landscape-level variables in explaining the severity of RTB damage. Result showed that two stand-level factors, aspect and canopy density, were the best predictors of damage in the early stage of RTB invasion. The landscape-level factor, the proportion of Chinese pine (Pinus tabuliformis) patches, was the main predictor of damage in the middle stage of RTB invasion. The most effective spatial scale at which RTB responded to landscape pattern was 250 m. With the increasing severity of RTB damage, the factors driving RTB invasion have shifted from the stand-level to the landscape-level. This calls for an urgent consideration of multi-scale processes to address the changing disturbance regimes in ecosystem management.
Solidified Liquid Metal with Regulated Plasticity for Channel-Free Construction of 3D Structured Flexible Electronics
Authors: Li Guoqiang , Zhang Mingyang , Liu Sanhu , Yuan Man , Wu Junjie , Yu Mei , Xu Zhiwu , Guo Jinhong , Guanglin Li , Liu Zhiyuan , Ma Xing 
Published: June 2021

Abstract
Gallium alloy based liquid metals (LMs) have shown great promise for soft and stretchable electronics in virtue of intrinsic fluidity and metallic conductivity. However, it has been a challenge by using LM to construct 3D structured circuits which are crucial for building flexible electronics with high integration. Hereby, taking advantage of the solid-liquid phase transition and plastic deformation of a Ga-10In LM alloy, we propose a novel strategy to fabricate LM based flexible electronic devices, in particular comprised of 3D circuits, without the need to pre-fabricate microchannels. We demonstrate applications including 3D interconnect arches for the integration of a multi-channel LED array, a 3D structured wearable sensor and a multilayer flexible circuit board for monitoring of finger movement. The current work provides a facile strategy for constructing LM based flexible electronics, which is of particular interest for building highly integrated electronics of hierarchical structure involving complicated 3D circuits.
Analysis of Driving Factors Influencing Human Vaccine Development in Iran: a Cross-impact Analysis
Authors: Moradi-Lakeh Maziar , Goharinezhad Salime , AmirKafi Ali , Zahraei Seyed Mohsen , Esteghamati Abdolreza , Tehrani-Banihashemi Arash 
Published: June 2021

Abstract
Background: Despite many successes in Immunization programs in Iran, vaccine policymaking has confronted with important weaknesses, and more effort is required to improve progress and prepare for the preferred future. In order to address the challenges facing vaccine development, this study has defined to identify influential factors on the future of development of human vaccines in Iran for strengthening evidence-based policy-making.Method:This mixed-method study aimed to analyze the factors affecting the future of human vaccine development using Cross Impact Analysis. Firstly, with a scoping review, the factors affecting the future of human vaccine development were identified. Secondly, a semi-structured interview was carried out with the determined experts in this sphere to add more factors and confirm the identified factors in the Iran context. Finally, a cross-impact analysis (CIA) approach was applied to understand the complex relationships between the given factors. Thematic analysis was used for the qualitative data and MICMAC analysis was applied for characterizing the relationships between factors.Results: Seventeen key driving forces factors were first identified through reviewing and interviewing. These factors are weighted from zero-three and analyzed by MICMAC software. The CIA technique characterized the effect of each one of these factors on vaccine development and then elaborated on the interaction between them. The results revealed that strong leadership and governance, innovation ecosystem, and immunization information systems were critical driving forces for developing vaccines in Iran. In fact, the degree of influence of these factors is much stronger than the degree of their dependency in the future. So, the vaccine development system is basically dependent on these key drivers. Conclusion: This study explores interactions among factors affecting vaccine development by using cross-impact analysis. It indicates that interactions among the identified factors do have a major influence on the overall system. Understanding the interactions among factors help policymakers formulating successful strategies for shaping a desirable future. Future studies could ratify the findings from this research applying other methodological approaches.