bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring goal planning in mental health service delivery: a systematic review protocol
Authors: Stewart Victoria , McMillan Sara Sinclair , Roennfeldt Helena , El-Den Sarira , Ng Ricki , Wheeler Amanda J 
Published: May 2021

IntroductionGoal planning is widely recognised as an integral part of mental health service delivery and an important element in supporting recovery. Goal planning identifies priorities for treatment through discussion and negotiation between service users and health practitioners. Goal planning enhances motivation, directs effort, and focuses the development of strategies and treatment options to improve recovery outcomes and promote service users’ ownership of the recovery process. While goal planning is a common practice in mental health settings, evidence regarding its impact on treatment outcomes is lacking. This paper outlines a protocol for a systematic review that aims to explore the types of goals planned, experiences of service users and practitioners, and the effectiveness of goal planning as a mental health intervention.Methods and analysisA systematic search will be conducted during March 2021 by searching Medline, CINAHL, Embase, Scopus and PsycINFO electronic databases to answer the following questions: (1) What types of goals are being developed within mental healthcare?; (2) What is the evidence for the effectiveness of goal planning on health and well-being for mental health service users?; (3) What are the experiences of mental health service users and their treating healthcare practitioners in relation to goal planning?; and (4) What are the barriers and facilitators to effective goal planning in mental health settings? Two independent researchers will screen the articles, selecting literature that meets criteria. All literature, regardless of study design that involves adult participants, with a mental illness and reporting on goal planning will be considered for inclusion. Data will be extracted from all eligible articles regardless of study design and summarised in a table. Appropriate quality assessment and data synthesis methods will be determined based on included study designs.Ethics and disseminationNo ethics approval is required. The results will be disseminated through peer-reviewed publications and conference presentations.PROSPERO registration numberCRD42020220595.
New risk model is able to identify patients with a low risk of progression in systemic sclerosis
Authors: van Leeuwen Nina Marijn , Maurits Marc , Liem Sophie , Ciaffi Jacopo , Ajmone Marsan Nina , Ninaber Maarten , Allaart Cornelia , Gillet van Dongen Henrike , Goekoop Robbert , Huizinga Tom , Knevel Rachel , De Vries-Bouwstra Jeska 
Published: May 2021

ObjectivesTo develop a prediction model to guide annual assessment of systemic sclerosis (SSc) patients tailored in accordance to disease activity.MethodsA machine learning approach was used to develop a model that can identify patients without disease progression. SSc patients included in the prospective Leiden SSc cohort and fulfilling the ACR/EULAR 2013 criteria were included. Disease progression was defined as progression in ≥1 organ system, and/or start of immunosuppression or death. Using elastic-net-regularisation, and including 90 independent clinical variables (100% complete), we trained the model on 75% and validated it on 25% of the patients, optimising on negative predictive value (NPV) to minimise the likelihood of missing progression. Probability cutoffs were identified for low and high risk for disease progression by expert assessment.ResultsOf the 492 SSc patients (follow-up range: 2–10 years), disease progression during follow-up was observed in 52% (median time 4.9 years). Performance of the model in the test set showed an AUC-ROC of 0.66. Probability score cutoffs were defined: low risk for disease progression (<0.197, NPV:1.0; 29% of patients), intermediate risk (0.197–0.223, NPV:0.82; 27%) and high risk (>0.223, NPV:0.78; 44%). The relevant variables for the model were: previous use of cyclophosphamide or corticosteroids, start with immunosuppressive drugs, previous gastrointestinal progression, previous cardiovascular event, pulmonary arterial hypertension, modified Rodnan Skin Score, creatine kinase and diffusing capacity for carbon monoxide.ConclusionOur machine-learning-assisted model for progression enabled us to classify 29% of SSc patients as ‘low risk’. In this group, annual assessment programmes could be less extensive than indicated by international guidelines.
CspB and CspC are induced upon cold shock in Bacillus cereus strain D2
Authors: Li Haoyang , Yang Rui , Hao Linlin , Wang Chunli , Li Mingtang 
Published: May 2021

Bacillus cereus D2, a psychrotrophic strain, plays an essential role in the restoration of heavy metal-contaminated soils, especially at low temperatures. However, the cold shock response mechanisms of this strain are unclear. In this study, the cold shock response of B. cereus D2 was characterized; as per the Arrhenius curve, 10 °C was chosen as the cold shock temperature. Six cold shock-like proteins were found and temporarily named cold shock protein (Csp)1–6; the respective genes were cloned and identified. Quantitative real-time PCR results showed that csp1, csp2, csp3, and csp6 were overexpressed under cold shock conditions. Interestingly, after cloning the respective encoding genes into the pET-28a (+) vector and their subsequent transformation into E. coli BL21 (DE3), the strains expressing Csp2 and Csp6 grew faster at 10 °C, showing a large number of bacteria. These results suggest that Csp2 and Csp6 are the major cold shock proteins in B. cereus D2. Of note, the comparison of amino acid sequences and structures showed that Csp2 and Csp6 belong to the CspB and CspC families, respectively. Additionally, we show that the number of hydrophobic residues is not a determining feature of major Csps, while, on the other hand, the formation of an α-helix in the context of a leucine residue is the most dominant difference between major and other Bacillus and E. coli Csps.
Constraining neutrino mass in dark energy dark matter interaction and comparison with 2018 Planck results
Authors: Amiri Hamid Reza , Salehi Amin , Noroozi Amir Hossein 
Published: May 2021

AbstractIn this paper, we investigate the constraints on the total neutrino mass $$\sum m_{\nu }$$

∑

m
ν

in a cosmological model in which dark energy and neutrinos are coupled such that the mass of the neutrinos and potentials are function of the scalar field as $$m_{\nu }=m_{0}\exp (\frac{\alpha \phi }{m_{pl}})$$

m
ν

=

m
0

exp

(

α
ϕ

m

pl

)

and $$V(\phi )=m_{pl}^{4}\exp (\frac{-\lambda \phi }{m_{pl}})$$

V

(
ϕ
)

=

m

pl

4

exp

(

-
λ
ϕ

m

pl

)

respectively. The observational data used in this work include the type Ia supernovae (SN) observation (Pantheon compilation), CC, CMB and BAO data. We find that the neutrino mass is tightly constrained to $$\sum m_{\nu }< 0.125$$

∑

m
ν

<
0.125

eV 95% Confidence Level (C.L.) and the effective extra relativistic degrees of freedom to be $$N_{eff}=2.955^{+0.11}_{-0.12}$$

N

eff

=
2
.

955

-
0.12

+
0.11

68% C.L in agreement with the Standard Model prediction $$ N_{eff} = 3.046$$

N

eff

=
3.046

, matter-radiation equality, $$z_{eq}=3389^{+24}_{25}$$

z

eq

=

3389
25

+
24

(68% C.L). These results are in good agreement with the results of Planck 2018 where the limit of the total neutrino mass is $$\sum m_{\nu }<0.12$$

∑

m
ν

<
0.12

eV (95% C.L., TT, TE, EE + lowE + lensing + BAO) , $$N_{eff}=2.99^{+0.17}_{-0.17}$$

N

eff

=
2
.

99

-
0.17

+
0.17

(68% C.L., TT, TE, EE + lowE + lensing + BAO) and $$z_{eq}=3387^{+21}_{21}$$

z

eq

=

3387
21

+
21

(68% C.L TT, TE, EE + lowE + lensing + BAO).
Thermodynamics of scale-dependent Friedmann equations
Authors: Bargueño Pedro , Contreras Ernesto , Rincón Ángel 
Published: May 2021

AbstractIn this work, the role of a time-varying Newton constant under the scale-dependent approach is investigated in the thermodynamics of the Friedman equations. In particular, we show that the extended Friedman equations can be derived either from equilibrium thermodynamics when the non-matter energy momentum tensor is interpreted as a fluid or from non-equilibrium thermodynamics when an entropy production term, which depends on the time-varying Newton constant, is included. Finally, a comparison between black hole and cosmological thermodynamics in the framework of scale-dependent gravity is briefly discussed.
Impact of Morbid Obesity and Obesity Phenotype on Outcomes After Transcatheter Aortic Valve Replacement
Authors: McInerney Angela , Tirado‐Conte Gabriela , Rodes‐Cabau Josep , Campelo‐Parada Francisco , Tafur Soto Jose D. , Barbanti Marco , Muñoz‐Garcia Erika , Arif Mobeena , Lopez Diego , Toggweiler Stefan , Veiga Gabriela , Pylko Anna , Sevilla Teresa , Compagnone Miriam , Regueiro Ander , Serra Viçent , Carnero Manuel , Oteo Juan F. , Rivero Fernando , Barbosa Ribeiro Henrique , Guimaraes Leonardo , Matta Anthony , Giraldo Echavarria Natalia , Valvo Roberto , Moccetti Federico , Muñoz‐Garcia Antonio J. , Lopez‐Pais Javier , Garcia del Blanco Bruno , Campanha Borges Diego Carter , Dumont Eric , Gonzalo Nieves , Criscione Enrico , Dabrowski Maciej , Alfonso Fernando , de la Torre Hernández Jose M , Cheema Asim N. , Amat‐Santos Ignacio J. , Saia Francesco , Escaned Javier , Nombela‐Franco Luis 
Published: May 2021

Background
There is a paucity of outcome data on patients who are morbidly obese (MO) undergoing transcatheter aortic valve replacement. We aimed to determine their periprocedural and midterm outcomes and investigate the impact of obesity phenotype.

Methods and Results

Consecutive patients who are MO (body mass index, ≥40 kg/m
2
, or ≥35 kg/m
2
with obesity‐related comorbidities; n=910) with severe aortic stenosis who underwent transcatheter aortic valve replacement in 18 tertiary hospitals were compared with a nonobese cohort (body mass index, 18.5–29.9 kg/m
2
, n=2264). Propensity‐score matching resulted in 770 pairs. Pre–transcatheter aortic valve replacement computed tomography scans were centrally analyzed to assess adipose tissue distribution; epicardial, abdominal visceral and subcutaneous fat. Major vascular complications were more common (6.6% versus 4.3%;
P
=0.043) and device success was less frequent (84.4% versus 88.1%;
P
=0.038) in the MO group. Freedom from all‐cause and cardiovascular mortality were similar at 2 years (79.4 versus 80.6%,
P
=0.731; and 88.7 versus 87.4%,
P
=0.699; MO and nonobese, respectively). Multivariable analysis identified baseline glomerular filtration rate and nontransfemoral access as independent predictors of 2‐year mortality in the MO group. An adverse MO phenotype with an abdominal visceral adipose tissue:subcutaneous adipose tissue ratio ≥1 (VAT:SAT) was associated with increased 2‐year all‐cause (hazard ratio [HR], 3.06; 95% CI, 1.20–7.77;
P
=0.019) and cardiovascular (hazard ratio, 4.11; 95% CI, 1.06–15.90;
P
=0.041) mortality, and readmissions (HR, 1.81; 95% CI, 1.07–3.07;
P
=0.027). After multivariable analysis, a (VAT:SAT) ratio ≥1 remained a strong predictor of 2‐year mortality (hazard ratio, 2.78;
P
=0.035).

Conclusions
Transcatheter aortic valve replacement in patients who are MO has similar short‐ and midterm outcomes to nonobese patients, despite higher major vascular complications and lower device success. An abdominal VAT:SAT ratio ≥1 identifies an obesity phenotype at higher risk of adverse clinical outcomes.
Effect of Moderately but Persistently Elevated Lipid Levels on Risks of Stroke and Myocardial Infarction in Young Korean Adults
Authors: Park Jun‐Bean , Kim Da Hye , Lee Heesun , Lee Hyun‐Jung , Hwang In‐Chang , Yoon Yeonyee E. , Park Hyo Eun , Lee Seung‐Pyo , Choi Su‐Yeon , Kim Yong‐Jin , Cho Goo‐Yeong , Han Kyungdo , Kim Hyung‐Kwan 
Published: May 2021

Background
Identifying predictive markers for future atherosclerotic cardiovascular diseases may be helpful to motivate young adults to promote healthy lifestyle. We sought to determine the association between persistently elevated low‐density lipoprotein‐cholesterol (LDL‐C) and/or triglyceride levels and the atherosclerotic cardiovascular diseases risks in young adults.

Methods and Results
We conducted a nationwide population‐based cohort study of 1 887 853 statin‐naive adults aged 20 to 39 years, with LDL‐C <190 mg/dL, using the Korean National Health Insurance Service database. Persistently elevated LDL‐C and triglyceride levels were defined by ≥3 measurements of ≥160 and ≥175 mg/dL, respectively. The primary outcome was a composite of stroke and myocardial infarction. Among the study population, 11 121 (0.59%) and 167 373 (8.87%) had persistently elevated LDL‐C and triglycerides, respectively. During a median follow‐up of 5.2 years, 2170 and 1537 incidences of stroke (0.16%) and myocardial infarction (0.23%) occurred. Persistently elevated LDL‐C levels were significantly associated with increased risks of the primary outcome, with an adjusted hazard ratio (HR) of 1.396 (95% CI, 1.005–1.940). This association was independent of high‐density lipoprotein cholesterol. Persistently elevated triglycerides were significantly associated with increased risks of the primary outcome (HR, 1.120; 95% CI, 1.015–1.236), but attenuated after adjustment for high‐density lipoprotein cholesterol.

Conclusions
Persistently elevated LDL‐C and triglyceride levels were associated with atherosclerotic cardiovascular diseases risk in young Korean adults without severe hypercholesterolemia. These lipid abnormalities should be considered risk factors in young adults since their effects on lifetime atherosclerotic cardiovascular diseases risk may become more pronounced over the life course.
New Protosmylinae (Neuroptera: Osmylidae) from the early Eocene of western North America, with taxonomic remarks
Authors: MAKARKIN VLADIMIR N. , ARCHIBALD S. BRUCE , MATHEWES ROLF W. 
Published: May 2021

The osmylid subfamily Protosmylinae is revised based on our emended diagnosis: Petrushevskia Martynova, 1958 and Mesosmylidus Jepson et al., 2012 are excluded (both considered Osmylidae incertae sedis), and Sogjuta Martynova, 1958 is transferred to it from the Mesosmylininae. The late Eocene genus Protosmylus Krüger, 1913 is considered a junior synonym of Osmylidia Cockerell, 1908 based on a distinct apomorphy (deeply forked MA in the hind wing), syn. nov. Three new species of Osmylidia from the early Eocene of North America are described: O. donnae sp. nov. from Quilchena, O. glastrai sp. nov. from Republic, Washington, USA, and an unnamed species of Osmylidia is reported from Driftwood Canyon Provincial Park, British Columbia (all localities of the Okanagan Highlands series), and O. taliae sp. nov. from the Green River Formation of Colorado, USA.
Pembrolizumab Induced Acute Persistent Airway Disease in a Patient with Recurrent Respiratory Papillomatosis (RRP)
Authors: Marcus Kathryn , Lee Daniel J. , Wilson Jeffrey S. , Smith Richard J. H. , Puricelli Michael 
Published: May 2021

Objective: To present an uncommon but serious, recently identified complication of checkpoint inhibitor therapy in a patient treated with pembrolizumab infusion for disseminated recurrent respiratory papillomatosis (RRP). Methods: Case report. Results: A 43-year-old woman with underlying asthma developed acute hypoxic respiratory failure within 24 hours of her third infusion of pembrolizumab for treatment of intractable, disseminated recurrent respiratory papillomatosis. Pulmonary function testing revealed a severe intra-thoracic obstructive ventilatory defect. Discontinuation of pembrolizumab, ventilatory support, and treatment with systemic and inhaled corticosteroids resulted in resolution of respiratory failure; however, her underlying asthma remains poorly controlled. Conclusion: To our knowledge, this case is the first report of pembrolizumab-induced obstructive respiratory failure in a patient being treated for RRP.
Butterfly Cartilage Tympanoplasty as an Alternative to Conventional Surgery for Tympanic Membrane Perforations: A Systematic Review and Meta-Analysis
Authors: Huang Juntao , Teh Bing Mei , Shen Yi 
Published: May 2021

Objective: To compare the effectiveness of butterfly cartilage tympanoplasty (BCT) with that of conventional surgical approaches in the treatment of tympanic membrane perforations. Methods: A systematic search was performed by screening the PubMed, Embase, and Cochrane Library databases up to October 31, 2020. Two coauthors independently identified studies in accordance with the selection criteria. Data were pooled and analyzed via Review Manager version 5.3 and Stata version 12.0 software. The postoperative outcomes were measured and expressed as odds ratios (ORs) and standardized mean differences (SMDs). Additionally, heterogeneity was assessed through the I2 statistic. Results: A total of 15 articles were eligible for final inclusion. The OR values for the graft uptake rate, compared to conventional tympanoplasty, were 1.12 (95%CI: 0.56-2.22, I2 = 52%, P = .75) and 1.22 (95%CI: 0.58-2.59, I2 = 0%, P = .60), and the OR compared to fat plug myringoplasty was 3.02 (95%CI: 1.04-8.77, I2 = 0%, P = .04). The qualitative analysis of the hearing results reflected significant postoperative auditory gains with no significant differences between the BCT and control groups, indicating satisfactory and similar postoperative hearing improvement. Moreover, the operation time was shortened (SMD = −2.19, 95%CI: −2.79 to −1.59, I2 = 82%, P < .05), and the postoperative pain was less with the BCT approach. Conclusion: Butterfly cartilage tympanoplasty has satisfactory efficacy in terms of anatomical and functional results in small to medium perforations. It reduces operation time and postoperative pain. However, the effectiveness on large perforation requires further assessment by well-designed studies.
A Clinical Study of Platelet-Rich Fibrin Combined With Autologous High-Density Fat Transplantation in Augmentation Rhinoplasty
Authors: Yan Dan , Li Shuai-Hua , Zhang An-Li , Xiao Yao , Huang Ze-Chun 
Published: May 2021

Objective: This study was designed to analyze the clinical effect of autologous fat-granule transplantation in augmentation rhinoplasty and explore methods to improve the fat retention rate. Methods: A total of 70 enrolled patients were randomly divided into 2 groups: the platelet-rich fibrin (PRF) combined with high-density fat transplantation group (combined group) and the conventional fat-granule transplantation group (control group; n = 35 in each group). In the combined group, an appropriate amount of autologous fat was extracted and centrifuged, and the lower layer of high-density fat was taken and mixed with PRF isolated from whole blood for autotransplantation. In the control group, only fat was extracted and centrifuged for transplantation. The patients were followed up with for more than one year to observe the short- and long-term effects, complications, safety, and patient satisfaction. Results: Six months after the operation, the nasal shape was stable, the contour was higher and more stereoscopic than before, the average increase of nasal height was 3.0 mm in the combined group and 2.0 mm in the control group. No complications, such as fat embolism, infection, or necrosis occurred during the 1-year follow-up. The satisfaction rate between the 2 groups has statistical significance ( P < .05). Conclusion: Overall, PRF combined with autologous high-density fat transplantation is simple to perform, has a significantly increased fat-retention rate than the control group, and has stable long-term effects without obvious adverse reactions. A sufficient amount of fat and PRF transplantation can achieve a good orthopedic effect. Thus, this method can be widely used in clinical augmentation rhinoplasty.
Are public health measures and individualised care compatible in the face of a pandemic? A national observational study of bereaved relatives’ experiences during the COVID-19 pandemic
Authors: Mayland Catriona R , Hughes Rosemary , Lane Steven , McGlinchey Tamsin , Donnellan Warren , Bennett Kate , Hanna Jeffrey , Rapa Elizabeth , Dalton Louise , Mason Stephen R 
Published: May 2021

Background: COVID-19 public health restrictions have affected end-of-life care experiences for dying patients and their families. Aim: To explore bereaved relatives’ experiences of quality of care and family support provided during the last days of life; to identify the impact of factors associated with perceived support. Design: A national, observational, open online survey was developed and disseminated via social media, public fora and professional networks (June–September 2020). Validated instruments and purposively designed questions assessed experiences. Analysis used descriptive statistics, logistic regression and thematic analysis of free-text responses. Participants: Individuals (⩾18 years) who had experienced the death of a relative/friend (all care settings) within the United Kingdome during the COVID-19 pandemic. Results: Respondents ( n = 278, mean 53.4 years) tended to be female ( n = 216, 78%); over half were ‘son/daughter’ (174, 62.6%) to the deceased. Deceased individuals (mean 81.6 years) most frequently died in their ‘usual place of care’ ( n = 192, 69.3%). Analysis established five conceptual themes affecting individualised care: (1) public health restrictions compounding the distress of ‘not knowing’; (2) disparate views about support from doctors and nurses; (3) challenges in communication and level of preparedness for the death; (4) delivery of compassionate care; (5) emotional needs and potential impact on grief. Male respondents (OR 2.9, p = 0.03) and those able to visit (OR 2.2, p = 0.04) were independently associated with good perceptions of family support. Conclusion: Despite public health restrictions, individualised care can be enabled by proactive, informative communication; recognising dying in a timely manner and facilitating the ability to be present before death.
Impact of analgesia on cancer recurrence and mortality within 5 years after stage I non-small cell lung cancer resection
Authors: Rosboch Giulio Luca , Ceraolo Edoardo , De Domenici Ilaria , Guerrera Francesco , Balzani Eleonora , Lyberis Paraskevas , Ruffini Enrico , Brazzi Luca 
Published: May 2021

Objective: The choice of analgesia after cancer surgery may play a role in the onset of cancer recurrence. Particularly opioids seem to promote cancer cell proliferation and migration. Based on this consideration, we assessed the impact of perioperative analgesia choice on cancer recurrence after curative surgery for stage I non-small cell lung cancer (NSCLC). Methods: We retrospectively reviewed the records of all patients undergoing lung resection for stage I NSCLC between January 2005 and December 2012. Patients received analgesia either by peridural (PERI group) or intravenous analgesia with opioids (EV group). Follow-up was concluded in August 2019. Five-year cumulative incidence of recurrence and overall survival were evaluated and adjusted using a propensity score matching method. Results: A total of 382 patients were evaluated, 312 belonging to the PERI group (81.7%) and 70 to the EV group (18.3%). There was no statistically significant difference between the two groups in 5-year cumulative incidence of recurrence ( p = 0.679) or overall survival rates ( p = 0.767). These results were confirmed after adjustment for propensity score matching for cumulative incidence of recurrence ( p = 0.925) or overall survival ( p = 0.663). Conclusions: We found no evidence suggesting an association between perioperative analgesia choice and recurrence-free survival or overall survival in patients undergoing surgical resection of stage I NSCLC.