bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel transition clinic structure for adolescent and young adult patients with childhood onset rheumatic disease improves transition outcomes
Authors: Overbury Rebecca S. , Huynh Kelly , Bohnsack John , Frech Tracy , Hersh Aimee 
Published: December 2021

Background
The transition of health care from Pediatric to Adult providers for adolescents and young adults with chronic disease is associated with poor outcomes. Despite the importance of this transition, over 80% of these patients do not receive the services necessary to transition to Adult health care. In 2018, we initiated a transition clinic structure, integrating an Internal Medicine - Pediatrics trained Adult Rheumatologist in a Pediatric Rheumatology clinic to guide this transition. Our goal was to improve transition outcomes. We report the methods of this clinic and its preliminary outcomes.

Methods
For patients referred to the transition clinic, the Adult Rheumatologist assumed medical management and implemented a six-part modular transition curriculum. This curriculum included a Transition Policy, Transition Readiness Assessment, medication review and education, diagnosis review and education, and counseling on differences between Pediatric and Adult-oriented care. Eligible patients and their families were enrolled in a prospective observational outcomes research registry. Initial data from this transition clinic is reported including adherence with certain aspects of the transition curriculum and clinic utilization.

Results
The transition clinic Adult Rheumatologist saw 177 patients in 2 years, and 57 patients were eligible for, approached, and successfully enrolled in the registry. From this registry, all patients reviewed the Transition Policy with the Adult Rheumatologist and 45 (78.9%) completed at least one Transition Readiness Assessment. Of the 22 patients for whom transition was indicated, all were successfully transitioned to an Adult Rheumatologist. 17 (77.3%) continued care post-transition with the transition clinic Adult Rheumatologist, and 5 (22.7%) continued care post-transition with a different Adult Rheumatologist. The median time between the last transition clinic visit and first Adult clinic visit was 5.1 months.

Conclusions
Our experience demonstrated the success of our clinic model regarding participation in the transition curriculum and improved clinic utilization data. Our results are an improvement over transition rates reported elsewhere that did not implement our model. We believe that this structure could be applied to other primary care and subspecialty clinics.

Trial registration
This research was approved by the University of Utah Institutional Review Board (IRB) in January 2019 (IRB_00115964). Patients were retrospectively registered if involved prior to this date.
Comparison of non-subjective relative fungal biomass measurements to quantify the Leptosphaeria maculans—Brassica napus interaction
Authors: Schnippenkoetter Wendelin , Hoque Mohammad , Maher Rebecca , Van de Wouw Angela , Hands Phillip , Rolland Vivien , Barrett Luke , Sprague Susan 
Published: December 2021

Abstract
Background
Blackleg disease, caused by the fungal pathogen Leptosphaeria maculans, is a serious threat to canola (Brassica napus) production worldwide. Quantitative resistance to this disease is a highly desirable trait but is difficult to precisely phenotype. Visual scores can be subjective and are prone to assessor bias. Methods to assess variation in quantitative resistance more accurately were developed based on quantifying in planta fungal biomass, including the Wheat Germ Agglutinin Chitin Assay (WAC), qPCR and ddPCR assays.

Results
Disease assays were conducted by inoculating a range of canola cultivars with L. maculans isolates in glasshouse experiments and assessing fungal biomass in cotyledons, petioles and stem tissue harvested at different timepoints post-inoculation. PCR and WAC assay results were well correlated, repeatable across experiments and host tissues, and able to differentiate fungal biomass in different host-isolate treatments. In addition, the ddPCR assay was shown to differentiate between L. maculans isolates.

Conclusions
The ddPCR assay is more sensitive in detecting pathogens and more adaptable to high-throughput methods by using robotic systems than the WAC assay. Overall, these methods proved accurate and non-subjective, providing alternatives to visual assessments to quantify the L. maculans-B. napus interaction in all plant tissues throughout the progression of the disease in seedlings and mature plants and have potential for fine-scale blackleg resistance phenotyping in canola.
Timed protocol analysis of interconnected mobile IoT devices
Authors: Bouloukakis Georgios , Georgantas Nikolaos , Kattepur Ajay , Issarny Valerie 
Published: December 2021

AbstractWith the emergence of the Internet of Things (IoT), application developers can rely on a variety of protocols and Application Programming Interfaces (APIs) to support data exchange between IoT devices. However, this may result in highly heterogeneous IoT interactions in terms of both functional and non-functional semantics. To map between heterogeneous functional semantics, middleware connectors can be utilized to interconnect IoT devices via bridging mechanisms. In this paper, we make use of the Data eXchange (DeX) connector model that enables interoperability among heterogeneous IoT devices. DeX interactions, including synchronous, asynchronous and streaming, rely on generic post and get primitives to represent IoT device behaviors with varying space/time coupling. Nevertheless, non-functional time semantics of IoT interactions such as data availability/validity, intermittent connectivity and application processing time, can severely affect response times and success rates of DeX interactions. We introduce timing parameters for time semantics to enhance the DeX API. The new DeX API enables the mapping of both functional and time semantics of DeX interactions. By precisely studying these timing parameters using timed automata models, we verify conditions for successful interactions with DeX connectors. Furthermore, we statistically analyze through simulations the effect of varying timing parameters to ensure higher probabilities of successful interactions. Simulation experiments are compared with experiments run on the DeX Mediators (DeXM) framework to evaluate the accuracy of the results. This work can provide application developers with precise design time information when setting these timing parameters in order to ensure accurate runtime behavior.
Well-posedness analysis of a stationary Navier–Stokes hemivariational inequality
Authors: Ling Min , Han Weimin 
Published: December 2021

AbstractThis paper provides a well-posedness analysis for a hemivariational inequality of the stationary Navier-Stokes equations by arguments of convex minimization and the Banach fixed point. The hemivariational inequality describes a stationary incompressible fluid flow subject to a nonslip boundary condition and a Clarke subdifferential relation between the total pressure and the normal component of the velocity. Auxiliary Stokes hemivariational inequalities that are useful in proving the solution existence and uniqueness of the Navier–Stokes hemivariational inequality are introduced and analyzed. This treatment naturally leads to a convergent iteration method for solving the Navier–Stokes hemivariational inequality through a sequence of Stokes hemivariational inequalities. Equivalent minimization principles are presented for the auxiliary Stokes hemivariational inequalities which will be useful in developing numerical algorithms.
Variation of psychological and anthropometrics measures before and after dieting and factors associated with body dissatisfaction and quality of life in a Lebanese clinical sample
Authors: Haddad Chadia , Zakhour Maha , Sacre Hala , Eid Nicole , Wehbé Georgie , Farha Joelle , Azar Jocelyne , Obeid Sahar , Hallit Souheil 
Published: December 2021

AbstractObjectiveThe primary objective of this study was to assess a change in the psychological states (stress, self-esteem, anxiety and depression), anthropometric measurements and physical/mental quality of life before and after diet in a sample of Lebanese subjects visiting a diet clinic. The secondary objectives included the evaluation of factors associated with body dissatisfaction, mental and physical quality of life (QOL) before the intervention of the diet program and the change in quality of life after this intervention among those participants.MethodsThis cross-sectional study, conducted between May and August 2018, enrolled 62 participants recruited from three diet clinics. The QOL was measured using the 12-item Short Form Health Survey (SF-12) and the psychological states was measured using the following scales: The Rosenberg Self-esteem Scale, Perceived Stress Scale, Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale.ResultsA significant reduction in body dissatisfaction, anxiety, waist, weight and body fat and a significant increase in the physical and mental quality of life was seen after diet compared to before it (p < 0.001 for all). No significant variation in perceived stress (p = 0.072), self-esteem (p = 0.885), and depression (p = 0.353) after diet were found. Higher BMI (β = 0.440) and higher anxiety (β = 0.132) were associated with higher body dissatisfaction scores, whereas higher self-esteem (β = − 0.818) was significantly associated with lower body dissatisfaction. Higher perceived stress (β = − 0.711), higher body dissatisfaction (β = − 0.480) and being a female (β = − 4.094) were associated with lower mental QOL. Higher Physical Activity Index was significantly associated with higher mental and physical QOL (β = 0.086 and β = 0.123 respectively).ConclusionThe results indicate the effectiveness of diet programs in enhancing the quality of life, psychological and anthropometric measures.
Performance of concrete beams partially/fully reinforced with glass fiber polymer bars
Authors: Moawad Mohamed S. , Fawzi Ahmed 
Published: December 2021

AbstractOne of the major advantages of using glass fiber-reinforced polymer bars as a replacement to the traditional steel-reinforced bars is its lightweight and high-resistant to corrosion. This research focuses on the performance of concrete beams partially/fully reinforced with glass fiber-reinforced polymer bars with 50% of GFRP bars were used to reinforce partially concrete beams at flexural zone. While 100% of GFRP bars were used to reinforce fully concrete beams at flexural and compression zones with different concrete compressive strength.This study reported the test results of 6 reinforced concrete beams with dimensions 150 × 200mm and a 1700-mm clear span length subjected to a four-point loading system. The tested beams were divided into three groups; the first one refers to the glass fiber-reinforced polymer bar effect. The second group is referring to the effect of concrete compressive strength, while the third group is referring to the effect of the GFRP bar volume ratio.Using longitudinal GFRP bars as a full or partial replacement of longitudinal steel bar reinforcement led to an increase in the failure load capacity and the average crack width, while a decrease in ductility was reported with a lower number of cracks. Increasing the concrete compressive strength is more compatible with GFRP bar reinforcement and enhanced the failure performance of beams compared with normal compressive strength concrete.
The mass release of migrants from UK immigration detention during the COVID-19 pandemic: what can be learned?
Authors: Waterman Lauren Z. , Pillay Mishka , Katona Cornelius 
Published: December 2021

SummaryConvincing international evidence demonstrates that immigration detention adversely affects mental health. During the COVID-19 outbreak, additional concerns were raised about the safety and appropriateness of immigration detention. Consequently, several hundred migrants were released en masse from UK immigration detention centres, and few new detentions took place. Over 70% fewer migrants were held in detention centres in June 2020 compared with December 2019. This large ‘natural experiment’ has demonstrated that detaining fewer migrants is possible and it provides an opportunity to review the necessity for large-scale detention for the purpose of immigration control, as well as its impact on health inequalities. Additionally, given that detainee release arrangements had already been considered unsafe prior to the pandemic, clinicians and service providers should take into consideration that many of those released may not be receiving adequate post-release continuity of care.
The Impact of Subclinical Hyperthyroidism on Cardiovascular Prognosis in Patients Undergoing Percutaneous Coronary Intervention
Authors: Yang Jie , Zheng Yitian , Li Chen , Liu Yupeng , Zhou Qing , Gao Jun , Meng Xiangbin , Zhang Kuo , Wang Wenyao , Shao Chunli , Tang Yi-Da 
Published: December 2021

Abstract

Context
Limited studies have focused on the impact of subclinical hyperthyroidism (SHyper) on poor prognosis in patients with known coronary artery disease (CAD).

Objective
We implemented the present study to explore the association between SHyper and adverse cardiovascular events in CAD patients who underwent drug-eluting stent implantation.

Methods
We consecutively recruited 8283 CAD patients undergoing percutaneous coronary intervention (PCI). All subjects were divided into 2 groups according to their thyroid function: group 1 (euthyroidism group, n = 7942) and group 2 (SHyper group, n = 341). After 1:4 propensity score (PS) matching, 1603 patients (332 SHyper group and 1271 euthyroidism group) were selected. The primary endpoint was major adverse cardiovascular events (MACEs), a composite of cardiac mortality, nonfatal myocardial infarction (MI), and target vessel revascularization (TVR).

Results
Kaplan–Meier (K-M) survival analyses suggested that there was no significant difference in the primary endpoint and secondary endpoints (MACE: 11.4% vs 8.8%, log-rank P = .124; cardiac death: 1.2% vs 0.9%, log-rank P = .540; nonfatal MI: 5.7% vs 4%, log-rank P = .177; and TVR: 6% vs 4.7%, log-rank P = .303) in the PS-matched population. Cox regression analysis indicated that SHyper was not an independent risk factor for MACEs (HR 1.33, 95% CI 0.92-1.92, P = .127).

Conclusion
SHyper is not independently associated with adverse cardiovascular events in CAD patients undergoing PCI. More studies should be implemented in the future to assess the long-term predictive value of SHyper with thyrotropin levels &lt;0.1 mIU/L for CAD patients undergoing PCI.
TAD-Net: An approach for real-time action detection based on temporal convolution network and graph convolution network in digital twin shop-floor
Authors: Hong Qing , Sun Yifeng , Liu Tingyu , Fu Liang , Xie Yunfeng 
Published: December 2021

Background: Intelligent monitoring of human action in production is an important step to help standardize production processes and construct a digital twin shop-floor rapidly. Human action has a significant impact on the production safety and efficiency of a shop-floor, however, because of the high individual initiative of humans, it is difficult to realize real-time action detection in a digital twin shop-floor. Methods: We proposed a real-time detection approach for shop-floor production action. This approach used the sequence data of continuous human skeleton joints sequences as the input. We then reconstructed the Joint Classification-Regression Recurrent Neural Networks (JCR-RNN) based on Temporal Convolution Network (TCN) and Graph Convolution Network (GCN). We called this approach the Temporal Action Detection Net (TAD-Net), which realized real-time shop-floor production action detection. Results: The results of the verification experiment showed that our approach has achieved a high temporal positioning score, recognition speed, and accuracy when applied to the existing Online Action Detection (OAD) dataset and the Nanjing University of Science and Technology 3 Dimensions (NJUST3D) dataset. TAD-Net can meet the actual needs of the digital twin shop-floor. Conclusions: Our method has higher recognition accuracy, temporal positioning accuracy, and faster running speed than other mainstream network models, it can better meet actual application requirements, and has important research value and practical significance for standardizing shop-floor production processes, reducing production security risks, and contributing to the understanding of real-time production action.
The modified Stulberg classification is a strong predictor of the radiological outcome 20 years after the diagnosis of Perthes’ disease
Authors: Huhnstock Stefan , Wiig Ola , Merckoll Else , Svenningsen Svein , Terjesen Terje 
Published: December 2021

Aims The aim of this study was to assess the prognostic value of the modified three-group Stulberg classification, which is based on the sphericity of the femoral head, in patients with Perthes’ disease. Methods A total of 88 patients were followed from the time of diagnosis until a mean follow-up of 21 years. Anteroposterior pelvic and frog-leg lateral radiographs were obtained at diagnosis and at follow-up of one, five, and 21 years. At the five- and 21-year follow-up, the femoral heads were classified using a modified three-group Stulberg classification (round, ovoid, or flat femoral head). Further radiological endpoints at long-term follow-up were osteoarthritis (OA) of the hip and the requirement for total hip arthroplasty (THA). Results There were 71 males (81%) and 17 females. A total of 13 patients had bilateral Perthes’ disease; thus 101 hips were analyzed. At five-year follow-up, 37 hips were round, 38 ovoid, and 26 flat. At that time, 66 hips (65%) were healed and 91 (90%) were skeletally immature. At long-term follow-up, when the mean age of the patients was 28 years (24 to 34), 20 hips had an unsatisfactory outcome (seven had OA and 13 had required THA). There was a strongly significant association between the modified Stulberg classification applied atfive-year follow-up and an unsatisfactory outcome at long-term follow-up (p < 0.001). Between the five- and 21-year follow-up, 67 hips (76%) stayed in their respective modified Stulberg group, indicating a strongly significant association between the Stulberg classifications at these follow-ups (p < 0.001). Conclusion The modified Stulberg classification is a strong predictor of long-term radiological outcome in patients with Perthes’ disease. It can be applied at the healing stage, which is usually reached five years after the diagnosis is made and before skeletal maturity. Cite this article: Bone Joint J 2021;103-B(12):1815–1820.
Quantitative analysis of formaldehyde solution based on terahertz attenuated total reflection and chemometric methods
Authors: Li Xuemin , Huang Haiqing , Zhou Wei , Li Dehua 
Published: December 2021

In order to explore the possibility of using terahertz attenuated total reflection (THz-ATR) technology combined with chemometric methods to quantitatively analyze different concentrations of formaldehyde solutions, the THz-ATR was applied to measure the formaldehyde solution with a concentration of 0% to 10%, and the absorption coefficient and refractive index of the samples in the frequency range of 0.2 to 1.2 THz were calculated. Partial least squares (PLS) and back propagation (BP) neural network (BPNN) algorithms are used to establish the mathematical model to predict the relation between the absorption coefficient and the concentration as well as the refractive index and the concentration. Correlation coefficient

R

and the root-mean-square error RMSE obtained from the PLS prediction model based on the refractive index are 98.99% and 0.4604, respectively, and those based on the absorption coefficient are 99.05% and 0.4464, respectively. Meanwhile, the correlation coefficient

R

and root-mean-square error RMSE obtained from the BPNN prediction model based on the refractive index are 99.80% and 0.2407, while those based on the absorption coefficient are 99.93% and 0.1182, respectively.
Long-term risk of a major cardiovascular event by apoB, apoA-1, and the apoB/apoA-1 ratio—Experience from the Swedish AMORIS cohort: A cohort study
Authors: Walldius Göran , de Faire Ulf , Alfredsson Lars , Leander Karin , Westerholm Peter , Malmström Håkan , Ivert Torbjörn , Hammar Niklas 
Published: December 2021

Background
Elevated apolipoprotein B (apoB) and elevated apoB/apoA-1 ratio increase the risk of myocardial infarction (MI) and stroke, whereas high apoA-1 is protective. We study how these apolipoproteins are associated with major adverse cardiovascular events (MACEs), whether apoA-1 contributes to this association, and whether abnormal values occur decades before such events develop.

Methods and findings
In the Swedish AMORIS (Apolipoprotein-related MOrtality RISk) cohort study, 137,100 men and women aged 25–84 years were followed an average 17.8 years. ApoB, apoA-1, and the apoB/apoA-1 ratio were analysed in relation to MACEs (non-fatal MI, stroke, and cardiovascular [CV] mortality), yielding 22,473 events. Hazard ratios (HRs) were estimated using Cox regression. Kaplan–Meier estimates were used to investigate the relationship of MACEs with increasing quintiles of the apoB/apoA-1 ratio in all age groups for both sexes. In nested case–control analyses, cases were randomly matched to age- and sex-matched controls, yielding population trajectories for apolipoproteins. Increased level of apoB and increased apoB/apoA-1 ratio were associated with risk of MACE and all clinical sub-components in both men and women across all ages (10th versus first decile in both sexes combined: HR 1.7 for MACE and 2.7 for non-fatal MI). Decreased values of apoA-1 potentiated the impact of apoB at all levels of apoB (on average across apoB range: 40% increase in HR for MACE and 72% increase in HR for non-fatal MI), indicating that the apoB/apoA-1 ratio covers a broader range of persons with dyslipidaemia at risk than apoB alone. In both men and women, MACEs occurred earlier on average for each increasing quintile of the apoB/apoA-1 ratio. Individuals with the highest levels of apoB/apoA-1 ratio experienced CV events on average several years earlier than those with lower ratios. Higher apoB/apoA-1 ratio in cases of MACE versus controls was seen already about 20 years before the event. A limitation of this study was that adjustment for tobacco smoking and hypertension was only possible in a small validation study.

Conclusions
An imbalance between apoB and apoA-1 resulting in an increased apoB/apoA-1 ratio is strongly associated with the outcome MACE and its sub-components, in both men and women of all ages. An increased apoB/apoA-1 ratio already 2 decades before events calls for early recognition and primary prevention. Simple evidence-based cut values should be considered in future cardiovascular guidelines.