bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Traditional Chinese Medicine Supportive Treatment on the Adherence of Behavioral Therapy for Insomnia: Study Protocol for a Randomized Controlled Trial
Authors: zheng yongliang , Qin Yiyu , Lu Yumeng , Li Liangliang , Chen Ya , Yao Zhaojuan 
Published: August 2021

Abstract
Background: Brief behavioral therapy (BBT-I) for insomnia has been proven to be a simple and effective alternative to cognitive behavioral therapy. However, low adherence limits the application in Chinese primary medical institutions, resulting in delayed or irregular treatment for many patients. This study aimed to explore the efficacy of traditional Chinese medicine supportive treatments on the adherence to behavioral therapy for insomnia in Chinese primary healthcare institutions, with a particular focus on patients who live in regions with weak healthcare systems.Methods: This randomized controlled clinical trial will be conducted in primary medical institutions and will recruit 98 adult participants with insomnia. BBT-I will be used as the base treatment. The participants will be divided into experimental (combined with traditional Chinese medicine supportive treatment n = 49) and control (combined with trazodone treatment, n = 49) groups, and each group will be treated for 4 consecutive weeks. The severity index of insomnia will be used as the main indicator of disease evaluation, with an 8-point reduction in the score considered as effective and a score < 8 considered as cured. The secondary indicators of the disease evaluation will include the Pittsburgh sleep quality index (PSQI), Zung’s self-rating anxiety scale, Zung’s self-rating depression scale, treatment adherence, and adverse event reports. All participants will be followed up at the time of enrollment, 4 weeks after treatment, and 3 months after the end of treatment.Discussion: This clinical trial will provide evidence for the efficacy of traditional Chinese medicine supportive treatment on the adherence to behavioral therapy for insomnia in primary medical institutions. This cheap and accessible model may benefit insomnia patients in medically underserved areas.Trial registration: Chinese Clinical Trial Registry ChiCTR2100042845. Registered on 30 January 2021, dataset: http://www.chictr.org.cn/edit.aspx?pid=65691&htm=4
Development of Multimode Gas Fired Combined Cycle Chemical-Looping Combustion Based Power Plant Lay-Outs
Authors: Jayadevappa Basavaraja Revappa 
Published: August 2021

Abstract
Operation of power plants in carbon dioxide capture and non-capture modes and energy penalty or energy utilization in such operations are of great significance. This work reports on two gas fired pressurized chemical-looping combustion power plant lay-outs with two inbuilt modes of flue gas exit namely, with carbon dioxide capture mode and second mode is letting flue gas (consists carbon dioxide and water) without capturing carbon dioxide. In the non-CCS mode, higher thermal efficiencies of 54.06% and 52.63% efficiencies are obtained with natural gas and syngas. In carbon capture mode, a net thermal efficiency of 52.13% is obtained with natural gas and 48.78% with syngas. The operating pressure of air reactor is taken to be 13 bar for realistic operational considerations and that of fuel reactor is 11.5 bar. Two power plant lay-outs developed based combined cycle CLC mode for natural gas and syngas fuels. A single lay-out is developed for two fuels with possible retrofit for dual fuel operation. The CLC Power plants can be operated with two modes of flue gas exit options and these operational options makes them higher thermal efficient power plants.
Economic assessment of incorporating the Hexavalent vaccine as part of the National Immunization Program of Peru
Authors: Seinfeld Janice , Rosales María Laura , Sobrevilla Alfredo , Yescas Juan Guillermo López 
Published: August 2021

Abstract
Background

This study aimed to estimate the economic impact of replacing the current Peruvian primary immunization scheme for infants under 1 year old with an alternative scheme with similar efficacy, based on a hexavalent vaccine.
Methods

A cost-minimization analysis compared the costs associated with vaccine administration, adverse reactions medical treatment, logistical activities, and indirect social costs associated with time spent by parents in both schemes. A budgetary impact analysis assessed the financial impact of the alternative scheme on healthcare budget.
Results

Incorporating the hexavalent vaccine would result in a 15.5% net increase in healthcare budget expenditure ($48,281,706 vs $55,744,653). Vaccination costs would increase by 54.1%, whereas logistical and adverse reaction costs would be reduced by 59.8% and 33.1%, respectively. When including indirect social costs in the analysis, the budgetary impact was reduced to 8.7%. Furthermore, the alternative scheme would enable the liberation of 17.5% of national vaccines storage capacity.
Conclusions

Despite of the significant reduction of logistical and adverse reaction costs, including the hexavalent vaccine into the National Immunization Program of Peru in place of the current vaccination scheme for infants under 1 year of age would increase the public financial budget of the government as it would represent larger vaccine acquisition costs. Incorporating the indirect costs would reduce the budgetary impact demonstrating the social value of the alternative scheme. This merits consideration by government bodies, and future studies investigating such benefits would be informative.
Device Selection in Patients with Borderline Size Aortic Valve Annulus Undergoing Transcatheter Aortic Valve Implantation
Authors: Talmor-Barkan Yeela , Kornowski Ran , Bar Noam , Ben-Shoshan Jeremy , Vaknin-Assa Hanna , Hamdan Ashraf , Kruchin Boris , Barbash Israel M. , Danenberg Haim , Perlman Gidon Y. , Konigstein Maayan , Finkelstein Ariel , Steinvil Arie , Merdler Ilan , Segev Amit , Barsheshet Alon , Codner Pablo 
Published: August 2021

Abstract
Transcatheter heart valve (THV) selection for transcatheter aortic valve implantation (TAVI) is crucial to achieve procedural success. Borderline aortic annulus size (BAAS), which allows a choice between two consecutive valve sizes, is a common challenge during device selection. In the present study, we evaluated TAVI outcomes in patients with BAAS according to THV size selection. We performed a retrospective study including patients with severe aortic stenosis (AS) and BAAS, measured by multidetector computed tomography (MDCT), undergoing TAVI with self-expandable (SE) or balloon-expandable (BE) THV from the Israeli multicenter TAVI registry. TAVI outcomes were assessed according to the Valve Academic Research Consortium-2 (VARC-2). Out of 2,352 patients with MDCT measurements, 598 patients with BAAS as defined for at least one THV type were included in the study. In BAAS patients treated with SE-THV, larger THV selection was associated with lower rate of paravalvular leak (PVL), compared to smaller THV (45.3% vs. 64.5%; pv = 0.0038). Regarding BE-THV, larger valve selection was associated with lower post-procedural transvalvular gradients compared to smaller THV (mean gradient: 9.9 ± 3.7mmHg vs. 12.5 ± 7.2mmHg; p = 0.019). Of note, rates of mortality, left bundle branch block, permanent pacemaker implantation, stroke, annular rupture and/or coronary occlusion did not differ between groups. BAAS is common among patients undergoing TAVI. Selection of a larger THV in these patients is associated with lower rates of PVL and better hemodynamic profile in patients implanted with SE and BE-THV, respectively, with no effect on procedural complications.
Colletotrichum Species Related To “Nam Dork Mai See Tong” Mango In Central Thailand And Risk Detection of Carbendazim-Resistant Strains
Authors: Bincader Santiti , Pongpisutta Ratiya , Rattanakreetakul Chainarong 
Published: August 2021

Abstract
Nam Dork Mai See Tong mango is a deluxe commercial fruit in Thailand, however anthracnose disease becoming a major problem affecting market-driven. Fungicide treatment is the main component in the mango anthracnose management, notwithstanding the appearance of fungal-resistance has been become a factor of fungicide limition and can affect to increasingly higher costs. Thirty-two isolates of the Colletotrichum species complex were obtained from anthracnose-diseased mango cv. Nam Dork Mai See Tong in 3 provinces of Thailand. Fungal identification based on morphological and molecular markers was investigated. All isolates were divided into 3 species: C. asianum , C. gloeosporioides and C. siamense . Pathogenicity tests revealed that all 3 species caused symptoms on artificially unwounded mango fruits and leaves. Only C. gloeosporioides have previously been reported on mango, while C. asianum and C. siamense were first reports associated with mango in Thailand. The responsiveness of Colletotrichum isolates to carbendazim was evaluated using an MIC assay. Nine isolates of C. asianum were highly resistant, while 5 and 8 isolates of C. gloeosporioides were resistant (R) and highly resistant (HR), respectively. Moreover, all isolates of C. siamense were HR. Mutations were detected by PCR of a partial sequence of the β-tubulin gene. The sequence of β-tubulin gene in HR strains showed a single nucleotide transversion of adenine to cytosine, resulting in a substitution at codon 198. However, R strains were found to have only an amino acid change at codon 200. Additionally, PCR-RFLP was applied as a rapid technique to detect carbendazim resistance. The results demonstrated that only the Bsh 1236I restriction enzyme generated two bands (200 and 300 bp) in the highly resistant strain, but these bands were absent in the sensitive (S) and R strains. Hence, PCR-RFLP technique showed the potential to specifically detect benzimidazole fungicide resistance in 3 species of Colletotrichum. Moreover, this technique is accessible and feasible for laboratory assessment
The Relationship between Urologic Cancer Outcomes and National Human Development Index: Trend in Recent Years
Authors: Xia Xiao-Fang , Wang Yi-Qiu , Shao Shi-Yi , Zhao Xin-Yu , Zhang Shi-Geng , Li Zhong-Yi , Yuan Yi-chu , Zhang Nan 
Published: August 2021

Abstract
ObjectivesTo describe the influence of the socioeconomic development on worldwide age-standardized incidence and mortality rates, as well as mortality-to-incidence ratio (MIR) and 5-year net survival of urologic cancer patients in recent years. MethodsThe Human Development Index (HDI) values were obtained from the United Nations Development Programme, data on age-standardized incidence/mortality rates of prostate, bladder and kidney cancer were retrieved from the GLOBOCAN database, 5-year net survival was provided by the CONCORD-3 program. We then evaluated the association between incidence/MIR/survival and HDI, with a focus on geographic variability as well as temporal patterns during the last 6 years.ResultsUrologic cancer incidence rates were positively correlated with HDIs, and MIRs were negatively correlated with HDIs. Prostate cancer survival also correlated positively with HDIs, solidly confirming the interrelation among cancer indicators and socioeconomic factors. Most countries experienced incidence decline over the most recent 6 years, and a substantial reduction in MIR was observed. Survival rates of prostate cancer have simultaneously improved.ConclusionDevelopment has a prominent influence on urologic cancer outcomes. HDI values are significantly correlated with cancer incidence, MIR and survival rates. HDI values have risen along with increased incidence and improved outcomes of urologic caner in recent years.
Keystone Microbiome in the Rhizosphere Soil Reveals the Effect of Long-Term Conservation Tillage on Crop Growth in the Chinese Loess Plateau
Authors: Jia Lijuan , Wang Zhen , Ji Lei , De Neve Stefaan , Paul C. Struik , Yao Yuqing , Lv Junjie , Zhou Tao , Jin Ke 
Published: August 2021

Abstract
Purpose Keystone taxa play an important role in soil nutrient cycling and crop growth and can be influenced by soil tillage. We investigated the composition of keystone taxa and their relationships with soil properties under different long-term tillage practices. Methods Four tillage treatments were applied (i.e., CT, conventional tillage; NT, no tillage with mulch; RT, reduced tillage; and SS, subsoiling with mulch), maintained for 21 years. Co-occurrence network (CoNet) was constructed to identify the keystone taxa, and redundancy analysis (RDA) was carried out to explore the relationships between keystone taxa and soil properties under four tillage practices at two growth stages (elongation and grain filling stages) of winter wheat. Results Compared with CT, RT had no significant effect on the microbial community and the keystone microbiome, while NT and SS remarkably altered the microbial community structure and the keystone microbiome at both crop stages. Massilia was the keystone genus under CT and RT, while Sphingomonas , Asanoa and Hoeflea were the keystone genera under NT and SS. RDA results showed that keystone genera were significantly correlated with soil organic carbon (SOC), dissolved organic carbon (DOC) and microbial biomass nitrogen (MBN) at both stages, but especially at the elongation stage. Our results further revealed that the effects of NT and SS on crop growth might be related to the changes in keystone microbiome. Conclusion Our study suggests that NT and SS were suitable conservation regimes and may contribute to the development of sustainable agricultural production in the Chinese Loess Plateau.
Assessing Strong Consistency of Symmetrical Solid-state Supercapacitors Based on Three-dimensional Porous Carbon Material
Authors: Le P.A. , Le Van Qui , Phung Thi Viet Bac , Nguyen Nghia Trong 
Published: August 2021

Abstract
Three-dimensional (3D) porous carbon material enhances the electrochemical performance of symmetrical solid-state supercapacitors which are prepared by using abundant biomass waste as electrodes and (PVA-Li2SO4) gel polymer electrolyte. A saving and simple carbonization method with KOH chemical activation is developed for synthesizing highly porous carbon from peanut shell with high specific surface area of 1348 m2 g–1, which can be reused the chemical activation solution. The electrodes making by such three-dimensional porous carbon in a 1 M Li2SO4 electrolyte demonstrates a maximum specific capacitance of 386 F g–1 at current density of 2 A g–1, energy density and power density of 53.61 Wh k g–1 and 1000 W kg–1, respectively. The symmetrical solid state supercapacitors with sandwich structure of (3D porous carbon P/PVA-Li2SO4/3D porous carbon P) exhibits a maximum specific capacitance of 116 F g-1 at current density of 0.5 A g–1. The energy density and power density are the value of 9 W h kg–1 and 380 W kg–1, respectively. Further, the supercapacitors also demonstrate good cycling stability 89 % retention after 7000 cycles.
PRMT7 Ablation in Cardiomyocytes Causes Cardiac Hypertrophy and Fibrosis Through β-Catenin Dysregulation
Authors: Ahn Byeong-Yun , Jeong Myong-Ho , Pyun Jung-Hoon , Jeong Hyeon-Ju , Vuong Tuan Anh , Bae Ju-Hyeon , An Subin , Kim Su Woo , Kim Yong Kee , Ryu Dongryeol , Kim Hyun-Ji , Cho Hana , Bae Gyu-Un , Kang Jong-Sun 
Published: August 2021

Abstract
Angiotensin II (AngII) has potent cardiac hypertrophic effects mediated through activation of hypertrophic signaling like Wnt/b-Catenin signaling. In the current study, we examined the role of protein arginine methyltransferase 7 (PRMT7) in cardiac function. PRMT7 was greatly decreased in hypertrophic hearts chronically infused with AngII and cardiomyocytes treated with AngII. PRMT7 depletion in rat cardiomyocytes resulted in hypertrophic responses. Consistently, mice lacking PRMT7 exhibited displayed the cardiac hypertrophy and fibrosis. PRMT7 overexpression abrogated the cellular hypertrophy elicited by AngII, while PRMT7 depletion exacerbated the hypertrophic response caused by AngII. Similar with AngII treatment, the cardiac transcriptome analysis of PRMT7-deficient hearts revealed the alteration in gene expression profile related to Wnt signaling pathway. Inhibition of PRMT7 by gene deletion or an inhibitor treatment enhanced the activity of b-Catenin. PRMT7 deficiency decreases symmetric dimethylation of b-Catenin. Mechanistic studies reveal that methylation of arginine residue 93 in b-Catenin decreases the activity of b-Catenin. Taken together, our data suggest that PRMT7 is important for normal cardiac function through suppression of b-Catenin activity.
Free combination of dutasteride plus tamsulosin for the treatment of benign prostatic hyperplasia in South Korea: Analysis of drug utilization and adverse events using the National Health Insurance Review and Assessment Service database
Authors: Lulic Zrinka , Son Hwancheol , Yoo Sang-Bae , Cunnington Marianne , Kapse Pratiksha , Miller Diane , Cortes Vanessa , Park Suna , Bhak Rachel H. , Duh Mei Sheng 
Published: August 2021

Abstract
Objective: To assess the use and safety of free combination therapy (dutasteride and tamsulosin), dutasteride monotherapy, or tamsulosin monotherapy in patients with benign prostatic hyperplasia (BPH). Methods: This non-interventional retrospective cohort study used claims data from the Korea Health Insurance Review and Assessment-National Patient Sample database. Patients with BPH ≥40 years of age receiving combination therapy (dutasteride 0.5 mg and tamsulosin 0.4 mg daily) or dutasteride 0.5 mg, or tamsulosin 0.4 mg daily dose between 2012 and 2017 were included. The frequency, duration of treatment and risk of any adverse event (AE) or serious AE (SAE) was compared for combination therapy versus each monotherapy using non-inferiority testing. Results: Of 14,755 eligible patients, 1529 (10.4%) received combination therapy, 6660 (45.1%) dutasteride monotherapy, and 6566 (44.5%) tamsulosin monotherapy. The proportion of patients treated with combination therapy exceeded the pre-specified 3% threshold for ‘frequent’ use. Safety results indicated a similar risk of any AE and SAE irrespective of treatment group. The adjusted relative risk for any AE over the treatment observation period comparing combination therapy with dutasteride monotherapy was 1.07 (95% confidence interval [CI]: 1.03, 1.12), and with tamsulosin monotherapy was 0.98 (95% CI: 0.95, 1.02) demonstrating non-inferiority. The adjusted relative risk for any SAE was 1.07 (95% CI: 0.66, 1.74) and 0.90 (95% CI: 0.56, 1.45), compared with dutasteride and tamsulosin monotherapy, respectively. Although the SAE results did not statistically demonstrate non-inferiority of combination therapy based on pre-specified margins, the 95% CI for the risk ratio estimates included the null with a lower limit below the non-inferiority margins, indicating no meaningful differences in SAE risk between groups. Absolute SAE risks were low.Conclusion: Combination therapy with dutasteride and tamsulosin is frequently used in real-world practice in South Korea for treatment of BPH and demonstrates a safety profile similar to either monotherapy.
Puzzle based Learning in Undergraduate Studies
Authors: Malherbe Kathryn 
Published: August 2021

Abstract
All undergraduate Radiography students require training in image interpretation and evaluation of x-ray images in their second year of studies as part of work integrated learning.The method of teaching pedagogy influences the student's learning process and recall ability during examinations. if the teaching process moves to a student-centred approach, students become responsible for their own learning allowing active engagement and construction of their knowledge systems.Aim/ ObjectivesThe aim of the study is to implement and evaluate the use of puzzle-based learning in the teaching and learning process of undergraduate studiesObjectivesTo determine the efficacy of crossword and jigsaw puzzles as a novel teaching tool for medical imaging educationTo increase student's interest and involvement with image interpretation topicsTo improve and assess recognition and recall of medical terminologyTo improve the understanding of innovative learningMethodsThe study is a cross sectional qualitative research design.Approval will be obtained from the Research and Ethics Committee of health Sciences.Online consent will be obtained from students involved, by means of Google Form submission, followed by an information session on Blackboard collaborate on the topic "Image evaluation and interpretation of radiographic imaging".ConclusionThe research will prove the important collaboration of active teaching methodologies with simple, easy to use didactic material to improve student's understanding of basic concepts in their core module subject
The Effectiveness of Cognitive-Behavioral Stress Management on Social Adjustment and General Health of Patients with Diabetes
Authors: maqsoud azam mirzaei , sahaghi hakim , maqsoud zeinab mirzaei 
Published: August 2021

Abstract
Background: The current study aimed to evaluate the effectiveness of cognitive-behavioral stress management on social adjustment and the general health of patients with diabetes in Ahwaz.Method: It is semi-experimental research with pre-test and post-test design and two groups. The statistical population included patients with diabetes, 30 of them were selected as the research sample and were randomly assigned into two groups of 15 (one experimental group and one control group). Bell's social adjustment questionnaire and General Health Questionnaire (GHQ) were used to measure variables.Results: The results showed that the post-test scores of social adjustment and general health were significantly different in the two groups.Conclusion: Cognitive-behavioral stress management can be effective in improving social adjustment and the general health of patients with diabetes, and it is necessary to pay attention to the psychological state of patients suffering from diabetes.
Quantifying and linking Sustainable Land-water-energy-food nexus: A perspective of sustainable livelihoods in Gidabo Watershed, East African Rift Valley
Authors: hatiya zinabu wolde , Wei Wu , Ketema Haile , Karikari Benjamin 
Published: August 2021

Abstract
BackgroundThe sustainable management of Land - Water - Energy - Food (LWEF) nexus requires an environmental characterization that allows the comparison of complex interlinkages between nexus resources and livelihoods. This complexity makes this characterization difficult coupled with limited study in quantifying sustainability of LWEF nexus and its linkage with livelihood. Therefore, the present study aimed to investigate the link between sustainable LWEF nexus and livelihoods. We used analytical hierarchy process and pairwise comparison matrix in combination with weighting model.ResultThe result of composite LWEF nexus index was 0.083 representing, low sustainability. This could be linked with nexus resources consumption, use, and management. From the analysis of the weight of land, water, energy and food nexus resources, the highest weight was observed for food. The focus of on food production only shows no clear synergy on provisioning, supporting or regulating nexus resources to address livelihoods. The result further showed that LWEF nexus resources have strong correlation with livelihoods. This was evidenced by social (r ≥ 0.8, P < 0.01), natural (r ≥ 0.3, P < 0.05) and physical (r ≥ 0.6, P < 0.01) livelihood indicators showed strong positive correlation with LWEF nexus resources.ConclusionBased on the finding of the study, it was observed that managing nexus resources not only provide a significant contribution to achieve sustainable LWEF nexus, but also be effective for enhancing livelihood through food security. This could be attained by strong evidence based policy to ensure sustainable use of nexus resources. The results provided by this study would serve as the foundation for future study, policy formulation and implementation.