bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noninvasive Chromosome Screening for Evaluating the Clinical Outcomes of Patients With Recurrent Pregnancy Loss or Repeated Implantation Failure
Authors: Xi Haitao , Qiu Lin , Yao Yaxin , Luo Lanzi , Sui Liucai , Fu Yanghua , Weng Qiuyi , Wang Jing , Zhao Junzhao , Zhao Yingzheng 
Published: December 2021

Abstract
Background: This retrospective cohort study determines whether noninvasive chromosome screening (NICS) for aneuploidy can improve the clinical outcomes of patients with recurrent pregnancy loss (RPL) or repeated implantation failure (RIF) in assisted reproductive technology.Methods: A total of 273 women with a history of RPL or RIF between 2018 and 2021 were included in this study. We collected data of all oocyte retrieval cycles and single blastocyst resuscitation transfer cycles.Results: For the RPL patients, NICS reduced the miscarriages rate per frozen embryo transfer (FET), improved the ongoing pregnancies rate and live birth rate: 17.9% vs 42.6%, adjusted OR 0.39, 95% CI 0.16–0.95; 40.7% vs 25.0%, adjusted OR 2.00, 95% CI 1.04–3.82; 38.9% vs 20.6%, adjusted OR 2.53, 95% CI 1.28–5.02, respectively. For the RIF patients, the pregnancy rates per FET in the NICS group were significantly higher than in the non-NICS group (46.9% vs. 28.7%, adjusted OR 2.82, 95% CI 1.20–6.66).Conclusions: This study demonstrated that selection of euploid embryos through NICS can reduce the miscarriage rate of patients with RPL and improve the clinical pregnancy rate of patients with RIF. Our data suggested that NICS could be used as a diagnostic test in clinical practice.
Epidemiology of Newcastle disease in chickens of Ethiopia: A systematic review and meta-analysis
Authors: Zegeye Asres , Temesgen Wudu , Molla Wassie , Lakew Mesfin 
Published: December 2021

Abstract
The objective of this systematic review was to estimate the overall pooled prevalence of Newcastle disease in chickens in Ethiopia and identify the sources of heterogeneity among and within studies. The seroprevalence of Newcastle disease was estimated using a single-group meta-analysis. Attempts were also made to identify study-level variables that could explain the heterogeneity in the apparent seroprevalence of the Newcastle disease. The findings were based on 16 published articles, 33 district-level reports and were limited to studies performed during 2005-2017. Due to the presence of heterogeneity, pooled analysis from different districts was conducted using random effects meta-analysis. The single-group summary of Newcastle disease seroprevalence in chickens was estimated to be 21.47% (19.54%-23.4%) with a 95% confidence interval. Our results indicated high inter-study variability (Cochran’s Q statistic = 196.2, true variance (τ2) = 0.36, inverse variance index (I2) = 90.0%, p<0.001). Of all variables analysed, diagnostic techniques and regions were the most significant predictors (p˂0.05) of heterogeneity. According to the diagnostic technique-based meta-analysis of random pooled prevalence, the haemagglutination inhibition test had the highest prevalence, followed by the enzyme-linked immunosorbent assay. In conclusion, the high-pooled prevalence estimates of the disease, combined with the scarcity of published data for the entire country of Ethiopia, indicate a significant data gap on the distribution of Newcastle disease in the country. While the high pooled prevalence tells the need for intervention to control the disease, there is also a need to assess the disease prevalence in all other parts of the country.
HPV 16 E6 Promotes Growth and Metastasis of Esophageal Squamous Cell Carcinoma cells in vitro
Authors: Hu Jiao Jiao , Ji Yu , Miao Ting Ting , Zheng Shi Yao , Cui Xiao Bin , Hu Jian Ming , Yang Lan , Li Feng 
Published: December 2021

Abstract
BackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Increasing evidence has revealed that Human Papillomavirus (HPV) infection may be associated with the possible etiology of ESCC. Nevertheless, the precise role of HPV in ESCC remains unclear.MethodsProliferation and apoptosis capability of ESCC cells upon infection of HPV16 E6 were detected by CCK-8 assay and Western blotting analysis. Wound healing assay and Transwell experiment were conducted to determine the ability of migration and invasion, and the mRNA expression of E6AP, p53, miR-34a was determined by real-time PCR after transfected with HPV16 E6 plasmid. ResultsIn ESCC cells, the ability of proliferation, migration and invasion were increased, and the ability of apoptosis was decreased after transfected with HPV16 E6 plasmid. Furthermore, the mRNA level of E6AP, P53 and miR-34a were decreased in HPV16 E6-transfected cell lines.Conclusions﻿Our results not only provide evidence that in ESCC, HPV16 E6 promotes cell proliferation, migration and invasion, inhibits cell apoptosis, but also suggest that there may be a correlation between E6AP, P53 and miR-34a in HPV-transfected cell lines. These findings indicated that HPV16 E6 may play an important role in the development of ESCC.
Early Onset of Intrahepatic Cholestasis of Pregnancy: a Case Report
Authors: Cemortan Maria , Stavinskaia Liudmila , Sagaidac Irina , Cernetchi Olga 
Published: December 2021

Abstract
Intrahepatic cholestasis of pregnancy (ICP) is a disorder characterized by pruritus and elevated liver function tests. Associated with a high incidence of adverse perinatal outcomes, ICP requires thorough attention in clinical practice. In addition, there is a high rate of stillbirth in cases of ICP. Women with ICP should be informed of the inability to predict stillbirth. Multi-disciplinary cooperation is critical for managing the condition and ensuring better pregnancy outcomes.
Evaluation in Cellulose Nanocrystals Effectiveness on Composite Film based Wound Dressing from Poly(vinyl alcohol) and Gum Tragacanth
Authors: Diem Luong Ngoc , Banerjee Indranil , Pal Kunal , Sukatta Udomlak , Rugthaworn Prapassorn , Sukyai Prakit 
Published: December 2021

Abstract
Biomaterial-based wound dressings were fabricated using cellulose nanocrystals (CNCs) as nano-filler in a polymeric mixture of poly(vinyl alcohol) (PVA) and gum tragacanth (GT) via solution casting. Physical and chemical characteristics of neat PVA, PVA/GT and PVA/GT/CNC films with varying concentrations (2 to 10%) of CNCs were observed. Initial analysis of CNCs showed nanosized particles of 104 nm length and 7 nm width. Scanning electron microscopy (SEM) illustrated cluster formations of CNCs in the polymer matrix. Fourier transform infrared (FTIR) spectrometry was used to confirm the chemical functional groups in the material. The presence of GT and CNCs in the polymer matrix improved water uptake and prolonged stability for 7 days. The CNCs enhanced tensile strength from 54.63 MPa to 80.39MPa. Biological properties of PVA/GT/CNC films were analyzed. Results showed that the dressing material was nontoxic to mouse fibroblast cells L929, while film loaded with betel leaf extract exhibited excellent antibacterial activities against Staphylococcus aureus DMST 8840 and Pseudomonas aeruginosa TISTR 781, indicating that composite film was suitable for application in wound dressing.
Identification of Landslide-prone Zones Using a GIS-based Multi-Criteria Decision Analysis and Region Growing Algorithm in Uncertain Conditions
Authors: beheshtifar sara 
Published: December 2021

Abstract
Landslides are considered to be one of the most significant natural hazards. Detection of landslide-prone zones is an important phase in landslide hazard assessment and mitigation of landslide-related losses. AHP as one of the most effective methods for GIS-based multi-criteria decision analysis is increasingly being used in susceptibility mapping. However, its weights have some degree of uncertainty that interval comparison matrix (ICM) method can be used to deal with this problem. The importance of this study is to propose an interval number distance-based region growing (IDRG) method based on ICM for the identification of landslide-prone zones in the Urmia lake basin, Iran. To assess the capability of the proposed IDRG method, a landslide susceptibility map was produced using common AHP, too. To generate the maps, the weights of nine conditioning factors were determined using both traditional pairwise comparison matrices (PCM) of the AHP method and ICM. The accuracy of the produced maps was assessed through ROC (receiver operating curve) and using a dataset of known landslide occurrences. The results indicate an improvement in accuracy of about 11% by identifying the landslide-prone zones using the IDRG method. This improvement was achieved by minimizing the uncertainty associated with criteria ranking/weighting in a traditional AHP and identifying the prone zones as areas instead of pixels.
A Non-Randomized Controlled Trial for the Effectiveness of the ‘Aibo’ Intervention Program for Distraction in Childhood Vaccination
Authors: Tanaka Kyoko , Hayakawa Maoko , Noda Chihiro , Nakamura Moemi , Nakamura Akio , Akiyama Chieko 
Published: December 2021

Abstract
Procedures and actions such as injections and immobilization cause pain and distress to children. In the pediatric field, there is a need for interventions and support to alleviate the pain and distress caused by such medical procedures. In recent years, the introduction of robots as a means of distraction has begun to be attempted. In this study, we conducted a non-randomized controlled trial to examine the effect of intervention using ‘aibo’, a dog-like robot which has artificial intelligence (AI), to promote distraction in children after vaccination. As a result, 57 children (32 in the intervention group) participated in the study. Results of a t-test with the control group showed that the intervention group using aibo had significantly less pain following the post-vaccination intervention than the control group using stuffed dog (Face Scale, t(55) = 2.582, p = .0125; Behavioral Observation Scale, t(55) = 2.772, p = .00759). The results support the hypothesis that the aibo intervention group will be less distressed and able to calm down more quickly after vaccination than the control group. Conclusion : AI-powered aibo interventions that allow for interactive interaction can be an effective distraction method during painful procedures such as vaccinations.
Prediction of Hydraulic Flow in the New Zohr Carbonate Reservoir, Eastern Mediterranean Using Artificial Neural Networks
Authors: Lala Amir 
Published: December 2021

Abstract
A new gas reservoir includes the carbonates of upper-Cretaceous Formation in the Zohr oilfield of eastern Mediterranean Sea in Egypt. The main aim of this study is to assess the new carbonate reservoir by thin section study and estimate hydraulic flow units HFUs by smart system. This carbonate formation is now considered the most important gas reservoir in northern Egypt. In this paper five microfacies were identified based on microscope petrographic analysis. The examined rocks were formed in lagoon, shoal and open marine depositional environments. The relationships between microfacies and flow units are further evaluated in this study. The determination of such relationships have proven to be challenging due to petrographic complications arising from diagenetic processes. The correlation behind pore space percentage and permeability is important to recognize hydraulic flow in the reservoir under consideration in this study.
Low carbon transition of global power sector enhances sustainable development goals
Authors: Peng Kun , Li Jiashuo , Feng Kuishuang , Chen Bin , Shan Yuli , Zhang Ning , Wang Peng , Fang Kai , Bai Yanchao , Zou Xiaowei 
Published: December 2021

Abstract
Low-carbon power transition, key to combatting climate change, brings far-reaching effects on achieving Sustainable Development Goals (SDGs), in terms of resources use, environmental emissions, employment, and many more. Here we assessed the potential impacts of power transition on 49 regional multiple SDGs progress under three different climate scenarios. We found that power transition could increase global SDG index score from 72.36 in 2015 to 74.38 in 2040 under the 1.5℃ scenario, compared with 70.55 and 71.44 under ‘Coal-dependent’ and ‘Middle of the road’ scenario, respectively. The power transition related global SDG progress would mainly come from switching to renewables in developing economies. Power transition also improves the overall SDG in most developed economies under all scenarios, while undermining their employment-related SDG progress. The global SDG progress would be jeopardized by power transition related international trade changes under ‘Coal-dependent’ and ‘Middle of the road’ scenario, while improved under the 1.5℃ scenario.
Soil Type Modifies the Impacts of Warming and Snow Exclusion on Carbon and Nutrient Losses
Authors: Juice Stephanie M. , Schaberg Paul G. , Kosiba Alexandra M. , Waite Carl E. , Hawley Gary J. , Wang Deane , Perdrial Julia N. , Adair E. Carol 
Published: December 2021

Abstract
The varied and wide-reaching impacts of climate change are occurring across heterogeneous landscapes. Despite the known importance of soils in mediating biogeochemical nutrient cycling, there is little experimental evidence of how soil characteristics may shape ecosystem response to climate change. Our objective was to clarify how soil characteristics modify the impact of climate changes on carbon and nutrient leaching losses in temperate forests. We therefore conducted a field-based mesocosm experiment with replicated warming and snow exclusion treatments on two soils in large (2.4 m diameter), in-field forest sapling mesocosms. We found that nutrient loss responses to warming and snow exclusion treatments frequently varied substantially by soil type. Indeed, in some cases, soil type nullified the impact of a climate treatment. For example, warming and snow exclusion increased nitrogen (N) losses on fine soils by up to four times versus controls, but these treatments had no impact on coarse soils. Generally, the coarse textured soil, with its lower soil-water holding capacity, had higher nutrient losses (e.g., 12-17 times more total N loss from coarse than fine soils), except in the case of phosphate, which had consistently higher losses (23-58%) from the finer textured soil. Furthermore, the mitigation of nutrient loss by increasing tree biomass varied by soil type and nutrient. Our results suggest that potentially large biogeochemical responses to climate change are strongly mediated by soil characteristics, providing further evidence of the need to consider soil properties in Earth system models for improving nutrient cycling and climate projections.
Comparison of Survival Between Unilocular Cystic and Purely Solid Renal Cell Carcinoma
Authors: Wang Yapeng , Niu Xiaoyu , Wang Lihui , Li Yunlong , Qiao Baoping 
Published: December 2021

Abstract
Purpose

To evaluate clinicopathologic features and survival outcomes of unilocular cystic renal cell carcinoma (cRCC) compared with purely solid renal cell carcinoma (RCC), and to evaluate the oncologic aggressiveness of unilocular cRCC.
Methods

The relevant data of 957 patients with sporadic unilateral RCCs underwent surgical treatment in 2 institutions from Jan 2014 to Oct 2018 were obtained. We excluded multilocular cystic renal neoplasm of low malignant potential (MCRNLMP), RCCs with multilocular cysts and necrotic RCCs. 74 unilocular cRCCs were identified by pathology reports. We performed propensity score matching (PSM) and randomly selected 148 purely solid RCCs. The clinicopathologic features and survival outcomes were compared properly.
Results

After PSM, age, BMI, Charlson Comorbidity Index, and postoperative Chronic Kidney Disease grade were not significantly different. Both overall survival and cancer-specific survival of unilocular cRCCs were significantly better than the purely solid RCCs by the log-rank test. Twenty-five cases of solid RCCs were in the pT3 or pT4 stage, while no pT3 or pT4 tumors were found in unilocular cRCCs. Fuhrman grade, pT stage, lymphatic metastasis and tumor diameter were found to be independent prognostic factors.
Conclusion

Unilocular cRCCs have a lower Fuhrman grade and pathological stage and a better prognosis compared with solid RCC. Unilocular cRCCs still probably have lymphatic metastasis at diagnosis and may have postoperative metastasis, which is different from MCRNLMP. We recommend that the diagnosis of unilocular cRCC should be reflected in pathology reports. Different subtypes of cRCC should be taken into consideration in counseling and management.
Marketing and Value Addition of Artemisia Annua Species and Other Potential Medicinal Plants in Southern Ethiopia
Authors: Gelgelo Gezehagn Gesese , Nunie Solomon Erifo , Mekonnen Tsegaye Bekele , Hintz Kendisha Soekardjo 
Published: December 2021

Abstract
Background: Medicinal plants play a pivotal role in the traditional medicine system in Ethiopia. Since the outbreak of the COVID-19 pandemic, domestic demand for medicinal plants has increased, particularly for Artemisia annua species. However, coupled with the secrecy nature in medicinal plant utilization, knowledge regarding marketing and value addition of medicinal plants is lacking in the literature. The objective of the present market study was to investigate the marketing and value addition of Artemisia annua and other major medicinal plants in selected towns of Southern Ethiopia. Methodology: Primary data were collected using questionnaire, focus group discussions, and personal observations with producers and traders. Marketing benefits of the potential medicinal plants were captured by total return and marketing margins. Result: The major medicinal plants in Chencha area were Artemisia annua, Stevia rebaudiana, and Silybum marianum, Echinops kebericho and Silene macrosolen Steud are widely used in Tula and Hawassa; Ocimum tenuiflorum and Ruta graveolens were found in Basha area, while Zehneria scabra was found in Chencha and Basha. The above-mentioned medicinal plants are used to treat various illnesses, while generating income to the local communities. The marketing or profit margins of the value-added products indicated a share of 28.6%, 14.36%, 14.31%, and 42.73% for producers, local collectors, and traders in Arbaminch and Addis Ababa, respectively. Conclusion: Up scaling the cultivation and commercialization of these medicinal plants has the potential to maintain the public health while providing alternative income sources for local communities in Ethiopia. In an effort to capture local value addition of medicinal plants, processing materials, market outlets, and road infrastructures should be improved.
Scalable Sulfonate-Coated Cotton Fibers as Facile Recyclable and Biodegradable Adsorbents for Highly Efficient Removal of Cationic Dyes
Authors: Li Linhua , Dou Baojie , Lan Jianwu , Shang Jiaojiao , Wang Yafang , Yu Jincheng , Ren Erhui , Lin Shaojian 
Published: December 2021

Abstract
Adsorbents with superior adsorption capacity and facile recyclability are viewed as promising materials for dye wastewater treatment. In this work, a novel sulfonate decorated cotton fiber as a biodegradable and recyclable adsorbent was fabricated for highly efficient removal of cationic dyes. Herein, the poly(sodium p-styrenesulfonate-co-N-methylol acrylamide) (P(SSNa-co-NMAM)) with SSNa units as adsorption sites and NMAM units as thermal-crosslinking points was synthesized for modification of cotton fibers in a large scale at high temperature (160 oC). The various characterization investigations confirmed the successful construction of the P(SSNa-co-NMAM) coated cotton fibers (PCF). As expected, the as-obtained adsorbent presented outstanding adsorption performance toward cationic dyes in the both static and dynamic states, even in the synthetic effluent. The adsorption processes of cationic dyes onto the PCF were well fitted by the Langmuir isotherm model and Pseudo-second-order kinetics, respectively. The thermodynamics study showed that the adsorption reaction of the cationic dyes onto PCF was a spontaneous and endothermic process. The maximum adsorption capacities of PCF toward MEB, RhB and MG were 3976.10, 2879.80 and 3071.55 mg/g, respectively. The responsible adsorption of dyes ontothe PCF was electrostatic interaction. Moreover, the adsorption capacity of PCF toward cationic dyes was slight influenced by pH value of solution, because of the stable feature of sulfonate moiety in acid and alkali. In addition, the as-prepared PCF exhibited satisfactory recyclability and reusability. Given the aforementioned results, the as-obtained PCF is a promising adsorbent with great potential for practical application in the dye-contaminated wastewater remediation.
Gynostemma Pentaphyllum Ameliorates Lipid Metabolic Abnormalities in Diabetic Kidney Disease
Authors: Wang Pengrui , Jiao Shouhai , Sun Li , Sun Helin , Wang Cunzhi , Sun Hengyi , Zhang Zhongwen 
Published: December 2021

Abstract
Background: Patients with diabetic kidney disease (DKD) were often accompanied with dislipidemia. Gynostemma pentaphyllum can ameliorate insulin resistance and reduce the synthesis of triglycerides and cholesterol, but the underlying mechanism is still unclear. Therefore, we used the network pharmacologic strategies to evaluate potential therapeutic effects and protective mechanisms of gynostemma pentaphyllum on diabetic kidney disease. Methods: Gynostemma pentaphyllum's potential targets were predicted using the TCMSP databases. The pathogenic factors involved in DKD and dislipidemia were screened by the OMIM and Gene Cards databases. The common targets of gynostemma pentaphyllum, DKD and dislipidemia were used to establish a protein-protein interaction (PPI) network. Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analysis were used to explore the potential molecular pathways. Results: The key targets for the therapeutic effects of gynostemma pentaphyllum included IL-6, AKT1, VEGFA, PTGS2, CCL2 and CASP3. Enrichment analysis showed that the underlying mechanism were mainly the involved in inhibition of inflammatory response, negative regulation of apoptotic process and angiogenesis. TNF, PI3K-Akt, and HIF-1 signaling pathways were considered as the key pathways. Conclusion: Gynostemma pentaphyllum played a therapeutic role in DKD complicated with dislipidemia, mainly through influencing inflammation response, apoptosis and angiogenesis.