bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient task offloading using particle swarm optimization algorithm in edge computing for industrial internet of things
Authors: You Qian , Tang Bing 
Published: July 2021

AbstractAs a new form of computing based on the core technology of cloud computing and built on edge infrastructure, edge computing can handle computing-intensive and delay-sensitive tasks. In mobile edge computing (MEC) assisted by 5G technology, offloading computing tasks of edge devices to the edge servers in edge network can effectively reduce delay. Designing a reasonable task offloading strategy in a resource-constrained multi-user and multi-MEC system to meet users’ needs is a challenge issue. In industrial internet of things (IIoT) environment, considering the rapid increase of industrial edge devices and the heterogenous edge servers, a particle swarm optimization (PSO)-based task offloading strategy is proposed to offload tasks from resource-constrained edge devices to edge servers with energy efficiency and low delay style. A multi-objective optimization problem that considers time delay, energy consumption and task execution cost is proposed. The fitness function of the particle represents the total cost of offloading all tasks to different MEC servers. The offloading strategy based on PSO is compared with the genetic algorithm (GA) and the simulated annealing algorithm (SA) through simulation experiments. The experimental results show that the task offloading strategy based on PSO can reduce the delay of the MEC server, balance the energy consumption of the MEC server, and effectively realize the reasonable resource allocation.
Utilization of Recycled Aggregate Concrete for Marine Site Based on 7-Year Field Monitoring
Authors: Chalee Wichian , Cheewaket Tieng , Jaturapitakkul Chai 
Published: July 2021

AbstractThis research aimed to create value of construction and demolition waste to be able used as a recycled coarse aggregate (RCA) in durable concrete, based on 7-year field investigation in marine site. Fly ash was used to substitute Portland cement type I in RCA concrete varied from 0 to 50% by weight of binder with three W/B ratios and comparing to natural aggregate (NA) concrete. Cubical concrete specimens were cast having round steel bars embedded with various concrete coverings to evaluate the durability performances. After 28-day curing, the specimens were placed at a tidal zone in the gulf of Thailand and investigated both mechanical and durability performances at 7-year exposed period. Based on site monitoring, 15–25% fly ash RCA concrete with W/B ratio of 0.40 would be advantaged to resist destruction due to the marine attack when compared with NA concrete with the same water-to-binder ratio.
Consistent estimation of strain-rate fields from GNSS velocity data using basis function expansion with ABIC
Authors: Okazaki Tomohisa , Fukahata Yukitoshi , Nishimura Takuya 
Published: July 2021

AbstractPresent day crustal displacement rates can be accurately observed at stations of global navigation satellite system (GNSS), and crustal deformation has been investigated by estimating strain-rate fields from discrete GNSS data. For this purpose, a modified least-square inversion method was proposed by Shen et al. (J Geophys Res 101:27957–27980, 1996). This method offers a simple formulation for simultaneously estimating smooth velocity and strain-rate fields from GNSS data, and it has contributed to clarify crustal deformation fields in many regions all over the world. However, we notice three theoretical points to be examined when we apply the method: mathematical inconsistency between estimated velocity and strain-rate fields, difficulty in objectively determining the optimal value of a hyperparameter that controls smoothness, and inappropriate estimation of uncertainty. In this study, we propose a method of basis function expansion with Akaike’s Bayesian information criterion (ABIC), which overcomes the above difficulties. Application of the two methods to GNSS data in Japan reveals that the inconsistency in the method of Shen et al. is generally insignificant, but could be clear in regions with sparser observation stations such as in islet areas. The method of basis function expansion with ABIC shows a significantly better performance than the method of Shen et al. in terms of the trade-off curve between the residual of fitting and the roughness of velocity field. The estimated strain-rate field with the basis function expansion clearly exhibits a low strain-rate zone in the forearc from the southern Tohoku district to central Japan. We also find that the Ou Backbone Range has several contractive spots around active volcanoes and that these locations well correspond to the subsidence areas detected by InSAR after the 2011 Tohoku-oki earthquake. Thus, the method of basis function expansion with ABIC would serve as an effective tool for estimating strain-rate fields from GNSS data.
Ground water-induced changes in velocities of P and S waves (Vp and Vs) measured using an accurately controlled seismic source
Authors: Suzuki Rina , Yamaoka Koshun , Tsuji Shuhei , Watanabe Toshiki 
Published: July 2021

AbstractWe analyze temporal variations in the travel times of both P and S waves (Vp and Vs) for 14 months at Toyohashi (central Japan) with a continuously operating vibration source that could efficiently produce both P and S waves. Seismic waves produced by the source, which is called the accurately controlled routinely operated signal system (ACROSS), are recorded by three nearby seismic stations, and the travel time variation at each station is estimated using the transfer function calculated from the recorded data. Long-term variations in Vp and Vs are observed and can be interpreted by the change in fluid saturation and crack density of the subsurface rocks. The variation in fluid saturation and crack density are consistent with that in the groundwater level, which is measured at the station nearest to the ACROSS. Short-term responses to rainfalls are observed at the station nearest to the ACROSS system; the interpretation of the changes in crack density and saturation is inconsistent with the ground water observation, partly owing to the initial response to rainfall. This can be interpreted as an air–water mixture within pores or cracks on a fine scale.
Best practices and opportunities for integrating nutrition specific into nutrition sensitive interventions in fragile contexts: a systematic review
Authors: Abdullahi Leila H. , Rithaa Gilbert K. , Muthomi Bonface , Kyallo Florence , Ngina Clementina , Hassan Mohamed A. , Farah Mohamed A. 
Published: July 2021

Abstract
Background
Annually, undernutrition contributes globally to 45% (3.1 million) of preventable deaths in children under 5. Effect following undernutrition i.e. physical growth & cognitive development etc. can be prevented during the first 1000 days also called window of opportunity. There is substantial evidence of positive nutrition outcomes resulting from integrating nutrition-specific interventions into nutrition specific program. However, there is paucity of knowledge on establishing and sustaining effective integration of nutrition intervention in fragile context. The objective of this review is to map and review the integration of nutrition-specific intervention to nutrition sensitive program and its impacts on nutrition outcomes.

Methods
In the study, we systematically searched the literature on integrated nutrition intervention into multi-sectoral programme in PUBMED, Google’s Scholar, the Cochrane Library, World Health Organisation (WHO), United Nations Children’s Fund (UNICEF), World Bank and trial registers from their inception until Oct 30, 2020 for up-to-date published and grey resources. We screened records, extracted data, and assessed risk of bias in duplicates. This study is registered with PROSPERO (CRD42020209730).

Result
Forty-four studies were included in this review, outlining the integration of nutrition-specific interventions among children 0–59 months with various existing programme. Most common integration platform in the study included integrated community case management and Integrated Management of Childhood Illness, Child Health Days, immunization, early child development, and cash transfers. Limited quantitative data were suggestive of some positive impact on nutrition and non-nutrition outcomes with a number of model of integration which varies according to the context and demands of the particular setting in which integration occurs.

Conclusion
Overall, existing evidence for nutrition sensitive and specific interventions is not robust and remains limited. It’s worthwhile to note, for future studies/interventions should be based on the context key criteria like relevance, political support, effectiveness, feasibility, expected contribution to health system strengthening, local capacities, ease of integration and targeting for sustainability, cost effectiveness and financial availability.
Ultrasonographic and resistance index evaluation of nails in psoriatic arthritis, psoriasis, and control groups: a cross-sectional study
Authors: De Rossi Samanta Daiana , Mendonça José Alexandre , Palominos Penelope Ester , Kohem Charles Lubianca , Cestari Tania Ferreira , da Silva Chakr Rafael Mendonça 
Published: July 2021

Abstract
Background
Nail psoriasis occurs frequently in patients with psoriatic disease, it can lead to functional impairment, pain, discomfort, decreased quality of life and can also be a predictor for the development of arthritis. Early recognition of this condition can provide early and effective treatment and prevent structural impairment. This study aims to identify nail ultrasonographic characteristics in three groups: psoriasis (PsO), psoriatic arthritis (PsA) and controls patients, to determine if the ultrasonography (US) can identify early signs of nail psoriatic impairment or local inflammation. We conducted nail US to determine nail matrix resistance index (NMRI), nail bed resistance index (NBRI), and power Doppler (PD) and grayscale (GS) parameters in these 3 groups.

Methods
Single-center, cross-sectional study. GS, PD, and spectral doppler images of bilateral 2nd and 3rd fingernails were acquired from 35 PsO, 31 PsA, and 35 controls patients. An US equipment with an 18 MHz linear transducer for GS and 8.0 MHz for PD was used. PD, NMRI, NBRI, nail plate thickness (NPT), nail bed thickness (NBT), nail matrix thickness (NMT), and morphostructural characteristics of the trilaminar structure (TS) were evaluated in saved images, blind.

Results
Mean NMRI and NBRI did not differ between groups. Linear regression analysis detected no relationships between PsO or PsA and NMRI or NBRI. Nail PD grade did not differ between groups. Type I and IV TS changes were more frequent in PsO; types II and III changes were more frequent in PsA (p < 0.001). NPT was greater in PsA and PsO groups than controls: PsA 0.73 ± 0.14 mm, PsO 0.72 ± 0.15 mm, Controls 0.67 ± 0.10 mm (p = 0.001).

Conclusion
Echographic TS characteristics of the nail plate and NPT evaluated by GS are useful and can distinguish PsO and PsA nails from controls. NMRI, NBRI, and US nail microcirculation parameters could not distinguish psoriatic nails.

Trial registration
72762317.4.0000.5327 (Certificate of Presentation of Ethical Appreciation – CAAE - Plataforma Brasil) Avaiable in https://plataformabrasil.saude.gov.br/login.jsf.
The genetic diversity of “papillomavirome” in bovine teat papilloma lesions
Authors: Sauthier Jéssica Tatiane , Daudt Cíntia , da Silva Flavio Roberto Chaves , Alves Christian Diniz Beduschi Travassos , Mayer Fabiana Quoos , Bianchi Ronaldo Michel , Driemeier David , Streit Rodrigo Silva Araujo , Staats Charley Christian , Canal Cláudio Wageck , Weber Matheus Nunes 
Published: July 2021

AbstractBackgroundPapillomaviruses are small nonenveloped, circular double-stranded DNA viruses that belong to thePapillomaviridaefamily. To date, 29Bos taurus papillomavirus(BPV) types have been described. Studies involving mixed BPV infections have rarely been reported in contrast to human papillomavirus (HPV), which is commonly described in numerous studies showing coinfections. Moreover, previous studies had shown that HPV coinfections increase the risk of carcinogenesis. In the present study, we used rolling-circle amplification followed by a high-throughput sequencing (RCA-HTS) approach in 23 teat papillomas from southern Brazil.ResultsEleven well-characterized BPV types and 14 putative new BPV types were genetically characterized into theXi,EpsilonandDyoxipapillomavirusgenera according to phylogenetic analysis of the L1 gene, which expands the previous 29 BPV types to 43. Moreover, BPV coinfections were detected in the majority (56.3%) of the papilloma lesions analyzed, suggesting a genetic diverse “papillomavirome” in bovine teat warts.ConclusionsThe data generated in this study support the possibility that a wide range of BPV is probably underdetected by conventional molecular detection tools, and that BPV coinfections are underestimated and probably genetic diverse. Additionally, 14 new BPV types were characterized, increasing the knowledge regarding BPV genetic diversity.
Environmentally enriched housing conditions affect pig welfare, immune system and gut microbiota in early life
Authors: Wen Caifang , van Dixhoorn Ingrid , Schokker Dirkjan , Woelders Henri , Stockhofe-Zurwieden Norbert , Rebel Johanna M. J. , Smidt Hauke 
Published: July 2021

AbstractBackgroundConventional pig housing and management conditions are associated with gastrointestinal pathophysiology and disease susceptibility in early life. Developing new strategies to reduce both therapeutic and prophylactic antibiotic use is urgent for the sustainable swine production globally. To this end, housing methodology providing effective environmental enrichment could be a promising alternative approach to reduce antibiotic usage, as it has been proven to positively influence pig welfare and immune status and reduce susceptibility to infections. It is, however, poorly understood how this enriched housing affects systemic and local pulmonary immune status and gut microbiota colonization during early life. In the present study, we compared the effects of two housing conditions, i.e., conventional housing: (CH) versus enriched housing (EH), on immune status and gut microbiota from birth until 61 days of age.ResultsThe expected benefits of enrichment on pig welfare were confirmed as EH pigs showed more positive behaviour, less aggression behaviour during the weaning transition and better human animal relation during the post weaning phase. Regarding the pigs’ immune status, EH pigs had higher values of haemoglobin and mean corpuscular volume in haematological profiles and higher percentages of T cells and cytotoxic T cells in peripheral blood. Furthermore, EH pigs showed higher ex vivo secretion of IL1ß and TNF-α after lipopolysaccharide stimulation of whole blood than CH pigs. The structure of the developing faecal microbiota of CH and EH pigs significantly differed as early as day 12 with an increase in the relative abundance of several bacterial groups known to be involved in the production of short chain fatty acids, such asPrevotella_2,Christensenellaceae_R_7_group andRuminococcus gauvreauiigroup. Furthermore, the main difference between both housing conditions post weaning was that on day 61, CH pigs had significantly larger inter-individual variation of ileal and colonic microbiota than EH pigs. In addition to housing, other intrinsic factors (e.g., sex) were associated with gut microbiota development and immune competence.ConclusionsIn addition to the known welfare benefits for pigs, environmentally enriched housing also positively drives important aspects of the development of the immune system and the establishment of gut microbiota in early life. Consequently, EH may contribute to increasing productivity of pigs and reducing antibiotic use.
Simulation and measurement of air quality in the traffic congestion area
Authors: Yu Shin , Chang Chang Tang , Ma Chih Ming 
Published: July 2021

AbstractThe traffic congestion in the Hsuehshan tunnel and at the Toucheng interchange has led to traffic-related air pollution with increasing concern. To ensure the authenticity of our simulation, the concentration of the last 150 m in Hsuehshan tunnel was simulated using the computational fluid dynamics fluid model. The air quality at the Toucheng interchange along a 2 km length highway was simulated using the California Line Source Dispersion Model. The differences in air quality between rush hours and normal traffic conditions were also investigated. An unmanned aerial vehicle (UAV) with installed PM2.5 sensors was developed to obtain the three-dimensional distribution of pollutants. On different roads, during the weekend, the concentrations of pollutants such as SOx, CO, NO, and PM2.5 were observed to be in the range of 0.003–0.008, 7.5–15, 1.5–2.5 ppm, and 40–80 μg m− 3, respectively. On weekdays, the vehicle speed and the natural wind were 60 km h− 1 and 2.0 m s− 1, respectively. On weekdays, the SOx, CO, NO, and PM2.5 concentrations were found to be in the range of 0.002–0.003, 3–9, 0.7–1.8 ppm, and 35–50 μg m− 3, respectively. The UAV was used to verify that the PM2.5 concentrations of vertical changes at heights of 9.0, 7.0, 5.0, and 3.0 m were 45–48, 30–35, 25–30, and 50–52 μg m− 3, respectively. In addition, the predicted PM2.5 concentrations were 40–45, 25–30, 45–48, and 45–50 μg m− 3 on weekdays. These results provide a reference model for environmental impact assessments of long tunnels and traffic jam-prone areas. These models and data are useful for transportation planners in the context of creating traffic management plans.
The association between bone mineral density and postoperative drainage volume following cruciate-substituting primary total knee arthroplasty: a cross-sectional study
Authors: Peerakul Yuthasak , Leeyaphan Jirapong , Rojjananukulpong Karn 
Published: July 2021

Abstract
Background
The prevalence of osteoporosis in patients who undergo a primary total knee arthroplasty (TKA) is increasing. Low bone mineral density (BMD) is related to unfavorable outcomes following TKA such as migration of uncemented tibial components. Postoperative blood loss in TKA is an important complication. Non-modifying predicting factors for postoperative blood loss in patients undergoing primary TKA need further elucidation. Studies on the association between BMD and blood loss after TKA are limited. We aimed to demonstrate the relationship between BMD and postoperative drainage volume following primary TKA.

Methods
A cross-sectional study was conducted between January 2014 and August 2020. A total of 119 primary varus osteoarthritis knees with BMD results were included in the study. Patients with secondary causes of osteoporosis were excluded.

Results
The median postoperative drainage volume of participants in the normal total hip BMD group and the normal trochanter BMD group was higher than that of patients in the low total hip BMD group and the low trochanter BMD group (285.0 ml vs 230.0 ml, P = 0.003; 282.5 ml vs 240.0 ml, P = 0.013, respectively). Multivariate regression analyses showed that operative time, spinal anesthesia, and normal total hip BMD status were significant predictive factors associated with increased postoperative drainage volume (P = 0.014, 0.022, and 0.013, respectively). No association was identified between the lumbar spine BMD status and postoperative drainage volume.

Conclusions
The relationship between BMD and postoperative blood loss in primary TKA was identified in this study. Normal total hip BMD was found to be associated with an increased postoperative drainage volume after primary TKA compared with low BMD.
Development and validation of RP HPLC method for the estimation of Sofosbuvir and related impurity in bulk and pharmaceutical dosage form
Authors: Ganji Shiny , Dhulipala Satyavati , Nemala Appala Raju 
Published: July 2021

Abstract
Background
The present work is aimed at development and validation of RP HPLC method which is simple, specific, precise, and accurate for estimation of Sofosbuvir and its process-related impurity in bulk and pharmaceutical dosage forms. Extensive literature survey revealed no method for estimation of the above said. The chromatographic separation was achieved on Agilent Eclipse XDB-C18, 4.6 × 250 mm, 5 μm with mobile phase composed of 0.1% trifluoroacetic acid in 1000 ml of water:acetonitrile (50:50) using an isocratic mode of elution. Detection was made using UV detector at 260.0 nm and LC solution software for analysis of data. The developed method was validated according to ICH guidelines.

Results
The linearity of calibration curve for Sofosbuvir in concentration range of 160-480 μg/ml was good. The curve was linear for its process related impurity (Phosphoryl) in concentration range of 10-30 μg/ml. There exists a good correlation between peak area and analyte concentration. Retention time for Sofosbuvir was found to be 3.674 min and its impurity was 5.704 min. Relative standard deviation values for Sofosbuvir is 1.741 and its process related impurity is 0.043. LOD for Sofosbuvir and its impurity was found to be 0.01% (0.04 μg) and 0.03% (0.12 μg) respectively. LOQ for Sofosbuvir and its impurity was found to be 0.50% (0.125 μg) and 1.50% (0.375 μg) respectively.

Conclusion
All the results reveal that the proposed method was found to be highly sensitive, simple, precise, accurate, robust, and fast. Large number of samples can be analyzed in shorter time due to shorter retention times, so it can be successfully applied for routine analysis of Sofosbuvir and related phosphoryl impurity in bulk and pharmaceutical dosage forms.
A Blood-based Polyamine Signature Associated With MEN1 Duodenopancreatic Neuroendocrine Tumor Progression
Authors: Fahrmann Johannes F , Wasylishen Amanda R , Pieterman Carolina R C , Irajizad Ehsan , Vykoukal Jody , Murage Eunice , Wu Ranran , Dennison Jennifer B , Krishna Hansini , Peterson Christine B , Lozano Guillermina , Zhao Hua , Do Kim-Anh , Halperin Daniel M , Agarwal Sunita K , Blau Jenny E , Del Rivero Jaydira , Nilubol Naris , Walter Mary F , Welch James M , Weinstein Lee S , Vriens Menno R , van Leeuwaarde Rachel S , van Treijen Mark J C , Valk Gerlof D , Perrier Nancy D , Hanash Samir M 
Published: July 2021

Abstract

Context
Duodenopancreatic neuroendocrine tumors (dpNETs) frequently occur in patients with multiple endocrine neoplasia type 1 (MEN1), and metastatic dpNET is the primary cause of disease-related mortality. There is a need for biomarkers that can identify patients with MEN1-related dpNETs that are at high risk of developing distant metastasis. Polyamines have tumor-promoting roles in several cancer types.

Objective
We hypothesized that MEN1-dpNET–related disease progression is associated with elevated levels of circulating polyamines.

Methods
Through an international collaboration between The University of Texas MD Anderson Cancer Center, the National Institutes of Health, and the University Medical Center Utrecht, plasma polyamine levels were assessed using mass spectrometry in 84 patients with MEN1 (20 with distant metastatic dpNETs [patients] and 64 with either indolent dpNETs or no dpNETs [controls]). A mouse model of MEN1-pNET, Men1fl/flPdx1-CreTg, was used to test time-dependent changes in plasma polyamines associated with disease progression.

Results
A 3-marker plasma polyamine signature (3MP: N-acetylputrescine, acetylspermidine, and diacetylspermidine) distinguished patients with metastatic dpNETs from controls in an initial set of plasmas from the 3 participating centers. The fixed 3MP yielded an area under the curve of 0.84 (95% CI, 0.62-1.00) with 66.7% sensitivity at 95% specificity for distinguishing patients from controls in an independent test set from MDACC. In Men1fl/flPdx1-CreTg mice, the 3MP was elevated early and remained high during disease progression.

Conclusion
Our findings provide a basis for prospective testing of blood-based polyamines as a potential means for monitoring patients with MEN1 for harboring or developing aggressive disease.