bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Dispositional and Instructional Time Perspective on Academic Performance and Motivations Among Primary School Students: A Concordance Hypothesis
Authors: Li Kin-Kit , Yip Hiu Yan Vincy , Wong Yuen Shan Noel 
Published: November 2021

Background:Dispositional future time perspective (FTP) has been acknowledged for its benefits on academic outcomes. Lacking in the literature are 1) understanding of FTP in children, 2) experimental studies, and 3) evidence for time perspective concordance (i.e., matching between dispositional and instructional FTP yield favorable outcomes).Aims:Therefore, this study examined whether dispositional FTP, instructional FTP, and their interaction were associated with academic outcomes including reading performance and academic motivations among primary school students.Sample:The participants were grade-2 or grade-3 Hong Kong students (N= 92; Age:M= 8.05,SD= 0.72; 45% girls).Methods:The participants rated their dispositional FTP and were randomly assigned to draw a picture of their future or present self with the assumption that they study hard. The students then completed a reading task and rated their intrinsic motivation, extrinsic motivation, and amotivation.Results:Better reading scores were found in future-oriented students who drew a future self and those less future-oriented who drew a present self. No concordance effects were found on motivations. Nevertheless, the future-drawing task led to a greater extrinsic motivation than the present-drawing task.Conclusions:Some children may have developed FTP in their middle childhood. Academic motivations may be more malleable at a younger age. When facing incongruent instructional context, more cognitive resources may be drained to resolve the dissonance and, thus, compromise the cognitive performance. Rather than a predominant focus on future achievements, a balanced emphasis on present and future or a temporally tailored instructional context for individuals may be considered in primary education.
Identification of Key Immune-Related Genes in the Progression of Septic Shock
Authors: Niu Jingjing , Qin Bingyu , Wang Cunzhen , Chen Chao , Yang Jianxu , Shao Huanzhang 
Published: November 2021

Objective: Septic shock is the severe complication of sepsis, with a high mortality. The inflammatory response regulates the immune status and mediates the progression of septic shock. In this study, we aim to identify the key immune-related genes (IRGs) of septic shock and explore their potential mechanism.Methods: Gene expression profiles of septic shock blood samples and normal whole blood samples were retrieved from the Gene Expression Omnibus (GEO) and Genotype-Tissue Expression Portal (GTEx). The differential expression genes (DEGs) and septic shock-specific immune-related genes (SSSIRGs) were evaluated and identified, along with the immune components by “cell type identification by estimating relative subsets of RNA transcripts (CIBERSORT, version x)” algorithm. Additionally, in order to explore the key regulatory network, the relationship among SSSIRGs, upstream transcription factors (TFs), and downstream signaling pathways were also identified by Gene Set Variation Analysis (GSVA) and co-expression analysis. Moreover, the Connectivity Map (CMap) analysis was applied to find bioactive small molecules against the members of regulation network while Chromatin Immunoprecipitation sequencing (ChIP-seq) and Assay for Targeting Accessible-Chromatin with high-throughput sequencing (ATAC-seq) data were used to validate the regulation mechanism of the network.Results: A total of 14,843 DEGs were found between 63 septic shock blood samples and 337 normal whole blood samples. Then, we identified septic shock-specific 839 IRGs as the intersection of DEGs and IRGs. Moreover, we uncovered the regulatory networks based on co-expression analysis and found 28 co-expression interaction pairs. In the regulation network, protein phosphatase 3, catalytic subunit, alpha isozyme (PPP3CA) may regulate late estrogen response, glycolysis and TNFα signaling via NFκB and HLA; Kirsten rat sarcoma viral oncogene homolog (KRAS) may be related to late estrogen response and HLA; and Toll-like receptor 8 (TLR8) may be associated with TNFα signaling via NFκB. And the regulation mechanisms between TFs and IRGs (TLR8, PPP3CA, and KRAS) were validated by ChIP-seq and ATAC-seq.Conclusion: Our data identify three SSSIRGs (TLR8, PPP3CA, and KRAS) as candidate therapeutic targets for septic shock and provide constructed regulatory networks in septic shock to explore its potential mechanism.
Looking for Crumbs in the Obesity Forest: Anti-obesity Interventions and Obesity-Associated Cardiometabolic Traits in the Mexican Population. History and Systematic Review With Meta-Analyses
Authors: Garcia-Oropesa Esperanza M. , Martinez-Lopez Yoscelina E. , Ruiz-Cejudo Sonia María , Martínez-Ezquerro José Darío , Diaz-Badillo Alvaro , Ramirez-Pfeiffer Carlos , Bustamante-Fuentes Alejandra , Lopez-Sosa Elena B. , Moctezuma-Chavez Oscar O. , Nava-Gonzalez Edna J. , Perales-Torres Adriana L. , Perez-Navarro Lucia M. , Rosas-Diaz Marisol , Carter Kathleen , Tapia Beatriz , Lopez-Alvarenga Juan C. 
Published: November 2021

Mexicans and Mexican Americans share culture, genetic background, and predisposition for chronic complications associated with obesity and diabetes making imperative efficacious treatments and prevention. Obesity has been treated for centuries focused-on weight loss while other treatments on associated conditions like gout, diabetes (T2D), and hypertriglyceridemia. To date, there is no systematic review that synthesizes the origin of obesity clinics in Mexico and the efforts to investigate treatments for obesity tested by randomized clinical trials (RCT). We conducted systematic searches in Pubmed, Scopus, and Web of Science to retrieve anti-obesity RCT through 2019 and without an inferior temporal limit. The systematic review included RCT of anti-obesity treatments in the Mexican adult population, covering alternative medicine, pharmacological, nutritional, behavioral, and surgical interventions reporting metabolism-associated traits such as BMI, weight, waist circumference, triglycerides, glucose, among others. Only the studies with at least 3 months of treatment were included in the meta-analyses in order to reduce placebo effects. We found 634 entries, after removal of duplicates and screening the studies based on eligibility criteria, we analyzed 43 national, and 2 multinational-collaborative studies. Most of the national studies had small sample sizes, and the implemented strategies do not have replications in the population. The nutrition/behavioral interventions were difficult to blind, and most studies have medium-to-high risk of bias. Nutritional/behavioral interventions and medications showed effects on BMI, waist circumference, and blood pressure. Simple measures like pure water instead of sweet beverages decrease triglycerides and systolic blood pressure. Dark chocolate showed the highest effect for BMI and high blood pressure, and treatment with insulin increased weight in those with T2D. The study of obesity in Mexico has been on-going for more than four decades, the interest on RCT just increased until this millennium, but with small sample sizes and lack of replication. The interventions affect different cardiometabolic associated traits, which should be analyzed in detail in the population living near the Mexico-U.S. border; therefore, bi-national collaboration is desirable to disentangle the cultural effects on this population's treatment response.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020221436, identifier: CRD42020221436.
Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients
Authors: Lalic-Cosic Sanja , Dopsaj Violeta , Kovac Mirjana , Mandic-Markovic Vesna , Mikovic Zeljko , Mobarrez Fariborz , Antovic Aleksandra 
Published: November 2021

Background: Pre-eclampsia (P-EC) is associated with systemic inflammation, endothelial dysfunction and hypercoagulability. The role of extracellular vesicles (EVs) in coagulation disturbances affecting the development and severity of P-EC remains elusive. We aimed to evaluate the concentration of EVs expressing phosphatidylserine (PS) and specific markers in relation to the thrombin and fibrin formation as well as fibrin clot properties, in pregnant women with P-EC in comparison to healthy pregnant women of similar gestational age.Methods: Blood samples of 30 pregnant women diagnosed with P-EC were collected on the morning following admission to hospital and after delivery (mean duration 5 days). The concentration of the PS-exposing EVs (PS+ EVs) from platelets (CD42a+, endothelial cells (CD62E+), and PS+ EVs expressing tissue factor (TF) and vascular cell adhesion molecule 1 (VCAM-1) were measured by flow cytometry. Further phenotyping of EVs also included expression of PlGF. Markers of maternal haemostasis were correlated with EVs concentration in plasma.Results: Preeclamptic pregnancy was associated with significantly higher plasma levels of PS+ CD42a+ EVs and PS+ VCAM-1+ EVs in comparison with normotensive pregnancy. P-EC patients after delivery had markedly elevated concentration of PS+ CD42a+ EVs, CD62E+ EVs, TF+ EVs, and VCAM-1+ EVs compared to those before delivery. Inverse correlation was observed between EVs concentrations (PS+, PS+ TF+, and PlGF+) and parameters of overall haemostatic potential (OHP) and fibrin formation, while PS+ VCAM-1+ EVs directly correlated with FVIII activity in plasma.Conclusion: Increased levels of PS+ EVs subpopulations in P-EC and their association with global haemostatic parameters, as well as with fibrin clot properties may suggest EVs involvement in intravascular fibrin deposition leading to subsequent microcirculation disorders.
Associations Between Injury of the Parieto-Insular Vestibular Cortex and Changes in Motor Function According to the Recovery Process: Use of Diffusion Tensor Imaging
Authors: Park Seo Yoon , Yeo Sang Seok , Jang Sung Ho , Cho In Hee , Oh Seunghue 
Published: November 2021

Background and Purpose: Parieto-insular vestibular cortex (PIVC) injury can cause symptoms such as abnormal gait and affects the integration and processing of sensory inputs contributing to self-motion perception. Therefore, this study investigated the association of the vestibular pathway in the gait and motor function recovery process in patients with PIVC injury using diffusion tensor imaging (DTI).Methods: We recruited 28 patients with stroke with only PIVC injury and reconstructed the PIVC using a 1.5-T scanner for DTI. Fractional anisotropy (FA), mean diffusivity (MD), and tract volume were measured. The functional ambulatory category (FAC) test was conducted, and motricity index (MI) score was determined. These were conducted and determined at the start (phase 1), end of rehabilitation (phase 2), and during the follow-up 6 months after onset.Results: Although the tract volume of PIVC showed a decrease in subgroup A, all of DTI parameters were not different between two subgroups in affected side (p &gt; 0.05). The results of MI and FAC were significantly different according to the recovery process (p &lt; 0.05). In addition, FA of the PIVC showed a positive correlation with FAC in phase 2 of the recovery process on the affected side. On the unaffected side, FA of the PIVC showed a significant negative correlation with MI in all processes (p &lt; 0.05).Conclusion: The degree of projection pathways to PIVC injury at onset time seems to be related to early restoration of gait function. Moreover, we believe that early detection of the projection pathway for PIVC injury using DTI would be helpful in the clinical evaluation and prediction of the prognosis of patients with PIVC injury.
Development and Validation of a Novel Prognostic Nomogram for CD5-Positive Diffuse Large B-Cell Lymphoma: A Retrospective Multicenter Study in China
Authors: Shen Ziyuan , Wang Ling , Zhang Bingpei , Li Tianci , Li Dashan , He Chenlu , Xue Yuhao , Wang Ying , Li Bingzong , Liu Qinhua , Zhang Hao , Gu Weiying , Wang Fei , Wang Chunling , Shi Yuye , Ye Jingjing , Zhu Taigang , Miao Yuqing , Huang Shuiping , Sang Wei 
Published: November 2021

BackgroundCD5-positive diffuse large B-cell lymphoma (CD5+ DLBCL) is a rare subtype of DLBCL with invasive clinical features and poor prognosis. Current clinical variables based on prognostic systems for DLBCL are inadequate to accurately stratify the prognosis of CD5+ DLBCL.MethodsA total of 195 CD5+ DLBCL patients were retrospectively recruited from nine centers in Huaihai Lymphoma Working Group. MaxStat analysis was used to identify optimal cutoff points for continuous variables; univariable and multivariable Cox analyses were used for variable selection; Kaplan–Meier curve was used to analyze the value of variables on prognosis; and C-index, Brier score, and decision curve analysis were measured for predicting model performance.ResultsThe derivation and validation cohorts consisted of 131 and 64 patients. Of the whole cohort, median age at diagnosis was 61 years, of whom 100 (51.28%) were males and the 5‐year overall survival rate was 42.1%. MYC, BCL-2, and the coexpression of MYC/BCL-2 could distinguish the survival of CD5+ DLBCL. Multivariable analysis showed that age, IPI, red blood cell count, neutrophil count, MYC expression, and hepatosplenomegaly were independent predictors, and the prognostic nomogram was developed. The C‐index of the nomogram was 0.809 in the derivation and 0.770 in the validation cohort. Decision curve analysis proved that compared with IPI, the specific nomogram showed a better identification in CD5+ DLBCL.ConclusionThe proposed nomogram provided a valuable tool for prognosis prediction in patients with CD5+ DLBCL.
MIS-C Treatment: Is IVIG Always Necessary?
Authors: Licciardi Francesco , Baldini Letizia , Dellepiane Marta , Covizzi Carlotta , Mogni Roberta , Pruccoli Giulia , Orsi Cecilia , Rabbone Ivana , Parodi Emilia , Mignone Federica , Montin Davide 
Published: November 2021

Background: MIS-C is a potentially severe inflammatory syndrome associated with SARS-CoV-2 exposure. Intravenous immunoglobulin (IVIG) is considered the first-tier therapy, but it implies infusion of large fluid volumes that may worsen cardiac function.Patients and Methods: Since April 2020, we have developed a treatment protocol that avoids the infusion of IVIG as first-line therapy in the early phase of MIS-C. In this study, we retrospectively analyzed a cohort of consecutive patients treated according to this protocol between 01/04/2020 and 01/04/2021.Results: In the last year, 31 patients have been treated according to the protocol: 25 with high-dose pulse MP (10 mg/kg) and 6 with 2 mg/kg. 67.7% of the patients responded to the initial treatment, while the others needed a step-up, either with Anakinra (25.8%) or with MP dose increase (6.5%). IVIG was administered in four patients. Overall, only one patient (3.2%) needed ICU admission and inotropic support; one patient developed a small coronary artery aneurysm.Conclusions: Timely start of MP therapy and careful fluid management might improve the outcomes of MIS-C patients.
A Novel Method for the Enhancement of Composite Materials’ Terahertz Image Using Unsharp Masking and Guided Filtering Technology
Authors: Li Zhilong , Zuo Jian , Zhao Yuanmeng , Han Zhongde , Xu Zhihao , Zhao Yunzhang , Yang Chao , Hu Weidong , Zhang Cunlin 
Published: November 2021

When terahertz imaging technology is used for the nondestructive testing of composite materials, the signal is often affected by the experimental environment and internal noise of the system, as well as the absorption and scattering effect of the tested materials. The obtained image has degradation phenomena such as low contrast, poor resolution of small targets and blurred details. In order to improve the image quality, this paper proposes a novel method for the enhancement of composite materials’ terahertz image by using unsharp masking and guided filtering technology. The method includes the processing steps of hard threshold shrinkage denoising based on discrete wavelet transform, amplitude imaging, unsharp masking, guided filtering, contrast stretching, and pseudo-color mapping. In this paper, these steps are reasonably combined and optimized to obtain the final resulting image. To verify the effectiveness of the proposed method, a 150–220 GHz high frequency terahertz frequency modulated radar imaging system was used to image three commonly used sandwich structure composites, and the enhancement processing were carried out. The resulting images with significantly enhanced contrast, detail resolution and edge information were obtained, and the prefabricated defects were all detected; Five objective evaluation indexes including standard deviation, mean gradient, information entropy, energy gradient and local contrast were used to compare and analyze the processing results of different image enhancement methods. The subjective and objective evaluation results showed that the proposed method can effectively suppress the noise in terahertz detection signals, enhance the ability of defect detection and positioning, and improve the accuracy of detection. The proposed method in this paper is expected to play a positive role in improving the practicability of terahertz imaging detection technology and expanding its application fields.
Personality Factors in Colorectal Cancer: A Systematic Review
Authors: Galli Federica , Scotto Ludovica , Ravenda Simona , Zampino Maria Giulia , Pravettoni Gabriella , Mazzocco Ketti 
Published: November 2021

Background: The role of personality in cancer incidence and development has been studied for a long time. As colorectal cancer (CRC) is one of the most prevalent cancer types and linked with lifestyle habits, it is important to better understand its psychological correlates, in order to design a more specific prevention and intervention plan. The aim of this systematic review is to analyze all the studies investigating the role of personality in CRC incidence.Methods: All studies on CRC and personality up to November 2020 were scrutinized according to the Cochrane Collaboration and the PRISMA statements. Selected studies were additionally evaluated for the Risk of Bias according to the Newcastle-Ottawa Scale (NOS).Results: Eight studies met the inclusion criteria and were eventually included in this review. Two main constructs have been identified as potential contributors of CRC incidence: emotional regulation (anger) and relational style (egoism).Conclusion: Strong conclusions regarding the influence of personality traits on the incidence of CRC are not possible, because of the small number and the heterogeneity of the selected studies. Further research is needed to understand the complexity of personality and its role in the incidence of CRC and the interaction with other valuable risk factors.
The Transition From Maternity Blues to Full-Blown Perinatal Depression: Results From a Longitudinal Study
Authors: Luciano Mario , Sampogna Gaia , Del Vecchio Valeria , Giallonardo Vincenzo , Perris Francesco , Carfagno Marco , Raia Maria Luce , Di Vincenzo Matteo , La Verde Marco , Torella Marco , Fiorillo Andrea 
Published: November 2021

Background: The aims of the present study are to: (1) assess the frequency of maternity blues (MB); (2) identify the clinical and social characteristics more frequently associated with the onset of depressive symptoms after delivery; and (3) verify the hypothesis that the presence of maternity blues is a risk factor for the onset of a full-blown depressive episode in the 12 months after delivery.Methods: This is a longitudinal observational study. All pregnant women who gave birth at the inpatient unit of Gynecology and Obstetrics of the University of Campania “Luigi Vanvitelli” from December 2019 to February 2021 have been invited to participate in the study. Upon acceptance, women were asked to complete the Italian version of the Edinburgh Postnatal Depression Scale along with an ad-hoc questionnaire on the women's sociodemographic, gynecological and peripartum characteristics as well as their psychiatric history. Women have been reassessed after one, 3, 6 and 12 months.Results: A total of 359 women were recruited within 3 days from delivery, with a mean EPDS total score of 5.51 (±4.20). Eighty-three women (23.1%) reported the presence of maternity blues. Mean EPDS total scores were 12.8 (±0.2) in the MB group vs. 4.26 (±0.2) in the group without MB (p &lt;0.0001). MB predictors were the presence of an anxiety disorder with an onset 6 months prior to pregnancy, of preeclampsia, of increased fetal health rate, of conflicts with relatives other than partner and having a partner with an anxiety disorder. At multivariate analyses the presence of MB increased 7-time the risk to have a higher EPDS score at follow-up assessments (OR: 7.79; CI: 6.88–8.70, p &lt;0.000). This risk is almost four times higher 1 months after the delivery (OR: 4.66; CI: 2.54–6.75, p &lt; 0.000), almost three times higher after 3 months (OR: 2.98; CI: 0.50–5.46, p &lt; 0.01) and almost six times higher after 12 months (OR: 5.88; CI: 3.20–8.54, p &lt; 0.000).Conclusions: Although MB was a self-limiting condition in the majority of cases, depressive symptoms arose quite often immediately after the childbirth. Professionals should be trained to monitor symptoms of MB and its transition toward a depressive episode.