bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transmitting Device Identifiers of Implants From the Point of Care to Insurers: A Demonstration Project
Authors: Krupka Dan C. , Graham Jove , Wilson Natalia A. , Li Angela , Landman Adam B. , Bhatt Deepak L. , Nguyen Louis L. , Reich Amanda J. , Gupta Avni , Zerhouni Yasmin A. , Capatch Kevin J. , Concheri Kevin P. , Weissman Joel S. 
Published: March 2021

Background
For implanted devices, an effective postmarket surveillance system does not exist. For medications, the Food and Drug Administration’s Sentinel Initiative plays that role, relying mainly on drug codes in insurance claims. Unique device identifiers (UDIs) could play an analogous role for implants, but there is no mandate for providers to include UDIs in claims or for payers to record them. Objections have been raised to incorporating UDIs into claims based on a potential burden on providers.

Methods
To assess this purported barrier, we modified information systems at 2 provider-payer dyads to allow for the transmission of UDI data from provider to payer. In addition, to illustrate the potential benefit of including device data in claims, we used our data to compare rates of 90-day adverse events after implantation using the electronic health record (EHR) alone with the EHR plus claims.

Results
The software system modifications were modest and performed as designed. Moreover, the level of difficulty of their development and implementation was comparable to that associated with a typical new release of an existing system. In addition, our data demonstrated the ability of claims-based data plus EHR data to reveal a larger percentage of postprocedure adverse events than data from EHRs alone.

Conclusions
Modifying information systems to allow for the transmission of UDI data from providers to payers should not impose a substantial burden on either. Implementation of a postmarket surveillance system based on such data in claims will require, however, the development of a system analogous to Sentinel.
Cerebrovascular Disease Correlates With Longitudinal Brain Atrophy in Virally Suppressed Older People Living With HIV
Authors: Samboju Vishal , Cobigo Yann , Paul Robert , Naasan Georges , Hillis Madeline , Tsuei Torie , Javandel Shireen , Valcour Victor , Milanini Benedetta 
Published: March 2021

Background:
Mild cognitive difficulties and progressive brain atrophy are observed in older people living with HIV (PLWH) despite persistent viral suppression. Whether cerebrovascular disease (CVD) risk factors and white matter hyperintensity (WMH) volume correspond to the observed progressive brain atrophy is not well understood.

Methods:
Longitudinal structural brain atrophy rates and WMH volume were examined among 57 HIV-infected participants and 40 demographically similar HIV-uninfected controls over an average (SD) of 3.4 (1.7) years. We investigated associations between CVD burden (presence of diabetes, hypertension, hyperlipidemia, obesity, smoking history, and atrial fibrillation) and WMH with atrophy over time.

Results:
The mean (SD) age was 64.8 (4.3) years for PLWH and 66.4 (3.2) years for controls. Participants and controls were similar in age and sex (P > 0.05). PLWH were persistently suppressed (VL <375 copies/mL with 93% <75 copies/mL). The total number of CVD risk factors did not associate with atrophy rates in any regions of interests examined; however, body mass index independently associated with progressive atrophy in the right precentral gyrus (β = −0.30; P = 0.023), parietal lobe (β = −0.28; P = 0.030), and frontal lobe atrophy (β = −0.27; P = 0.026) of the HIV-infected group. No associations were found in the HIV-uninfected group. In both groups, baseline WMH was associated with progressive atrophy rates bilaterally in the parietal gray in the HIV-infected group (β = −0.30; P = 0.034) and the HIV-uninfected participants (β = −0.37; P = 0.033).

Conclusions:
Body mass index and WMH are associated with atrophy in selective brain regions. However, CVD burden seems to partially contribute to progressive brain atrophy in older individuals regardless of HIV status, with similar effect sizes. Thus, CVD alone is unlikely to explain accelerated atrophy rates observed in virally suppressed PLWH. In older individuals, addressing modifiable CVD risk factors remains important to optimize brain health.
A Pretreatment Prognostic Score to Stratify Survival in Pancreatic Cancer
Authors: Hank Thomas , Hinz Ulf , Reiner Thomas , Malleo Giuseppe , König Anna-Katharina , Maggino Laura , Marchegiani Giovanni , Kaiser Jörg , Paiella Salvatore , Binco Alessandra , Salvia Roberto , Hackert Thilo , Bassi Claudio , Büchler Markus W. , Strobel Oliver 
Published: March 2021

Objective:
The aim of this study was to develop and validate a pretreatment prognostic score in pancreatic cancer (PDAC).

Background:
Pretreatment prognostication in PDAC is important for treatment decisions but remains challenging. Available prognostic tools are derived from selected cohorts of patients who underwent resection, excluding up to 20% of patients with exploration only, and do not adequately reflect the pretreatment scenario.

Methods:
Patients undergoing surgery for PDAC in Heidelberg from July 2006 to June 2014 were identified from a prospective database. Pretreatment parameters were extracted from the database and the laboratory information system. Parameters independently associated with overall survival by uni- and multivariable analyses were used to build a prognostic score. A contemporary cohort from Verona was used for external validation.

Results:
In 1197 patients, multiple pretreatment parameters were associated with overall survival by univariable analyses. American Society of Anesthesiology classification, carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen, C-reactive protein, albumin, and platelet count were independently associated with survival and were used to create the Heidelberg Prognostic Pancreatic Cancer (HELPP)-score. The HELPP-score was closely associated with overall survival (median survival between 31.3 and 4.8 months; 5-year survival rates between 35% and 0%) and was able to stratify survival in subgroups with or without resection as well as in CA19-9 nonsecretors. In the resected subgroup the HELPP-score stratified survival independently of pathological prognostic factors. The HELPP-score was externally validated and was superior to CA19-9 in both the development and validation cohorts.

Conclusion:
The HELPP-score is a readily available prognostic tool based on pretreatment routine parameters to stratify survival in PDAC independently of resection status and pathological tumor stage.
Donor CMV Reactivation as a Novel Risk Factor for CMV Replication in Seropositive Liver Transplant Recipients
Authors: Limaye Ajit P. , Rahnemai-Azar Amir A. , Nazarian Susanna M. , Perkins James D. , Reyes Jorge D. 
Published: March 2021

Background.
Risk factors for cytomegalovirus (CMV) viremia in CMV seropositive liver transplant recipients are incompletely defined and have focused primarily on recipient factors. We hypothesized that active CMV replication (CMV viremia) in seropositive donors might increase the risk for CMV viremia in recipients, as reported for other viruses in organ transplantation.

Methods.
From January 3, 2009, to July 27, 2015, stored plasma from consecutive CMV seropositive liver donors was retrospectively tested for CMV viremia by PCR. From April 20, 2012, to July 27, 2015, CMV seropositive recipients of a liver transplant from the donors during this time period received preemptive therapy for CMV prevention (valganciclovir therapy for CMV viremia ≥250 IU/mL). The association of recipient factors and donor CMV viremia with viremia in recipients was assessed.

Results.
Among 317 CMV-seropositive donors, CMV viremia was detected in 11 (3.5%) and was associated with longer time to collection after admission and bacteremia. Among 115 CMV-seropositive liver recipients, 5 (4.3%) received an organ from a donor with CMV viremia. Donor CMV viremia was independently associated with higher incidence of CMV viremia ≥250 IU/mL and shorter time to onset of CMV viremia ≥250 IU/mL in recipients: 4 (80%) versus 26 (23.6%), P = 0.02, and hazard ratio 8.55 (2.60–28.10), P = 0.003, respectively.

Conclusion.
Donor CMV reactivation is associated with CMV viremia in seropositive orthotopic liver transplant recipients receiving preemptive therapy, identifying a novel potential risk factor for CMV infection in seropositive liver transplant recipients. Future studies should independently validate and assess these findings in other organ transplant settings.
Biliary Strictures Are Associated With Both Early and Late Hepatic Artery Stenosis
Authors: Hann Angus , Seth Rashmi , Mergental Hynek , Hartog Hermien , Alzoubi Mohammad , Stangou Arie , El-Sherif Omar , Ferguson James , Roberts Keith , Muiesan Paolo , Oo Ye , Issac John R. , Mirza Darius , Perera M. Thamara P.R. 
Published: March 2021

Background.
Hepatic artery stenosis (HAS) following liver transplantation results in hypoperfusion and ischemic damage to the biliary tree. This study aimed to investigate how vascular intervention, liver function test derangement, and time point of HAS onset influence biliary complications.

Methods.
A single-center retrospective study of adult patients that underwent primary liver transplantation. Patients were grouped according to the presence or absence of HAS and then into early (≤90 d) or late (>90 d) subgroups. Biliary complications comprised anastomotic (AS) or non ASs (NASs).

Results.
Computed tomography angiography confirmed HAS was present in 39 of 1232 patients (3.2%). This occurred at ≤90 and >90 days in 20 (1.6%) and 19 (1.5%), respectively. The incidence of biliary strictures (BSs) in the group with HAS was higher than the group without (13/39; 33% versus 85/1193; 7.1%, P = 0.01). BS occurred in 8/20 (40.0%) and 5/19 (26.3%) of the early and late groups, respectively. The need for biliary intervention increased if any liver function test result was ≥3× upper limit of normal (P = 0.019).

Conclusions.
BS occurs at a significantly higher rate in the presence of HAS. Onset of HAS at ≤90 or ≥90 days can both be associated with morbidity. Significant liver function test derangement at HAS diagnosis indicates a higher likelihood of biliary intervention for strictures.
A Novel Surgical Technique to Assure Donor and Recipient Safety: Pyloric to Segment 4 Arterial Reconstruction
Authors: Fraile Andres , Mercado Luis M. , Paladini Hugo , Ramisch Diego A. , Descalzi Valeria , Yantorno Silvina , Farinelli Pablo A. , Schelotto Pablo Barros , Gondolesi Gabriel E. 
Published: March 2021

Background.
Strategies to extend the pool of organs include and promote the use of segmental liver grafts. While performing a living donor left lateral segment (LLS) liver transplant and in split procedures, the hepatic artery´s division becomes critical when a dominant segment 4 artery (S4A) emerges from the left hepatic artery (LHA). We aim to describe a novel technique that consists of performing microsurgical reconstruction from the pyloric artery (PA) to S4A.

Case Reports.
A 45-y-old living donor was evaluated to use his LLS as a graft for a pediatric recipient. During the procedure, a dominant S4A born from the LHA was dissected. To obtain an appropriate LHA length and diameter for the recipient, it was necessary to transect it. An extended right lobe split graft was used in a 61-y-old patient. The S4A born from LHA had to be sectioned during the split procedure. In both cases, segment 4 remained incompletely perfused. The PA was dissected with enough length to be rotated, to perform a microsurgical anastomosis to the S4A, recovering parenchyma’s color and Doppler signal while vascular permeability was demonstrated using CT scan. There was no biliary or cut surface complication.

Conclusions.
PA to S4A reconstruction is a simple and novel technique that can be used for LLS and extended right lobe split graft and might contribute to increase donor selection and reduce living donor and recipient S4A-related complications.
Semaphorin 3C attracts MGE-derived cortical interneurons in the deep migratory stream guiding them into the developing neocortex
Authors: Aiello Kiara , Bolz Jürgen 
Published: March 2021

AbstractWhile it is known that Semaphorin 3C acts as a guidance cue for axons during brain development, their potential role during interneuron migration is largely unknown. One striking observation is that Sema3C demarcates the pallial/subpallial border and the intracortical pathway of cortical interneurons in the dorsal telencephalon. Moreover, migrating cortical interneurons express Neuropilin1 and Neuropilin2, described receptors for Semaphorin 3A, 3F and 3C. All these reasons prompt us to examine possible roles for Sema3C on cortical interneuron migration.Using severalin vitroapproaches, we showed that Nrp1-expressing MGE-derived interneurons from the deep migratory stream migrate towards the increasing Sema3C gradients. In contrast, inhibitory neurons from the superficial migratory stream that express Nrp2, do not respond to this guidance cue. In the present study, we proposed that diffusible Sema3C expressed in the Pallium provides a permissive corridor that attracts the Nrp1-expressing interneurons from the DMS into the dorsal telencephalon.
Societal factors affecting on innovative sustainable development of nanotechnology: a morphological approach
Authors: Kousari Sahar , Ghazinoory Sepehr , Saghafi Fatemeh 
Published: March 2021

Purpose
This study aims to investigate the probable future scenarios of nanotechnology development and their implications in Iran considering anticipatory knowledge, suitable methodology and integral perspective.

Design/methodology/approach
The study used framework morphology, a method for creating scenarios and their implications developed by the Delphi method that covers the consistent morphological space and make contact with previous scenario work, as well as the current and projected research and policy situation in Iran.

Findings
The study identified five scenarios, namely, “no nano” scenario headlines picturing a future society that there is no impact of nanotechnology in it. The “nano flow” scenario and indicates prospering nanotechnology in the full sides of the market. The “no nano contact” scenario suspecting that apart from the already banned nanotechnological applications in food, cosmetics, clothes and agricultural applications might bear equally unacceptable risks. The “hidden nano” scenario by pointing out the effects of accidents and crimes traced back to intended or unintended misuse of nanotechnological applications. Then finally, the “red nano” scenario illustration headlines the prospects of medical, energy system efficiency and nanotechnological applications in information and communication technologies.

Practical implications
The policymakers could use the scenarios and their implications as part of its considerations in strategic planning.

Originality/value
This paper represents the first time that a framework for societal implications has been applied to nanotechnology development topic in Iran.
Grey variable dual precision rough set model and its application
Authors: Du Junliang , Liu Sifeng , Liu Yong 
Published: March 2021

PurposeThe purpose of this paper is to advance a novel grey variable dual precision rough set model for grey concept.Design/methodology/approachTo obtain the approximation of a grey object, the authors first define the concepts of grey rough membership degree and grey degree of approximation on the basic thinking logic of variable precision rough set. Based on grey rough membership degree and grey degree of approximation, the authors proposed a grey variable dual precision rough set model. It uses a clear knowledge concept to approximate a grey concept, and the output result is also a clear concept.FindingsThe result demonstrates that the proposed model may be closer to the actual decision-making situation, can effectively improve the rationality and scientificity of the approximation and reduce the risk of decision-making. It can effectively achieve the whitenization of grey objects. The model can be degenerated to traditional variable precision rough fuzzy set model, variable precision rough set model and classic Pawlak rough set, when some specific conditions are met.Practical implicationsThe method exposed in the paper can be used to solve multi-criteria decision problems with grey decision objects and provide a decision rule. It can also help us better realize knowledge discovery and attribute reduction. It can effectively achieve the whitenization of grey object.Originality/valueThis method proposed in this paper implements a rough approximation of grey decision object and obtains low-risk probabilistic decision rule. It can effectively achieve a certain degree of whitenization of some grey objects.
Assessing electricity and CO2 emission savings through energy efficiency measures in shopping malls in India: a feasibility study of appliance retrofit
Authors: Maheshwari Jyoti , Paliwal Pramod , Garg Amit 
Published: March 2021

Purpose
Energy-efficient retrofitting of existing buildings is an inexpensive way of reducing energy consumption and mitigating climate change impacts. The purpose of this study is to examine electricity savings and carbon dioxide (CO2) emission reduction potentials of energy-efficient retrofit measures for surveyed two large shopping malls in India.

Design/methodology/approach
A techno-economic model was developed to estimate the electricity savings achieved due to energy-efficient retrofit measures in shopping malls that were surveyed in 2017. Alternative scenarios were constructed based on capital cost and cost of conserved energy (CCE) value for retrofit measures: cheapest replacement, best available technology and best value for money. The life-cycle electricity and CO2 emission savings and payback period for end-use retrofit measures were evaluated.

Findings
The estimated average electricity savings were around 39–56% for various retrofit measures across all three scenarios while the average CO2 emission reductions were around 50–125 kt-CO2. Retrofits to light-emitting diode lights and air conditioners with inverter technology offered more life-cycle electricity savings. Paybacks for most lighting end-use measures were estimated to be within 1.5 years while for most space conditioning end-use measures were between 1 and 4 years.

Originality/value
The primary survey-based comprehensive research makes an exclusive contribution by estimating life-cycle electricity savings and CO2 emission reductions for energy-efficient retrofit measures of lighting and space cooling end-use appliances for existing shopping malls. The present research methodology can also be deployed in other types of commercial buildings and in residential buildings to estimate electricity savings from energy-efficient retrofit measures.
Arresting fake news sharing on social media: a theory of planned behavior approach
Authors: Pundir Vartika , Devi Elangbam Binodini , Nath Vishnu 
Published: March 2021

PurposeThis study aims to examine the collective impact of awareness and knowledge about fake news, attitudes toward news verification, perceived behavioral control, subjective norms, fear of missing out (FoMO) and sadism on social media users’ intention to verify news before sharing on social media.Design/methodology/approachThe current study’s conceptual framework is developed by a comprehensive literature review on social networking and the theory of planned behavior. The data for samples were collected from 400 respondents in India to test the conceptual framework using the partial least square–structural equation modeling technique.FindingsThe results show that awareness and knowledge, perceived behavioral control, attitudes toward news verification and FoMO are significant predictors of intention to verify news before sharing.Research limitations/implicationsThe present study concludes implications for managers of social media companies and policy actors that want to take steps toward arresting the spread of fake news via social media.Originality/valueAcademic investigation on fake news sharing on social media has recently gained traction. The current work is unique because it uses the theory of planned behavior as a basis for predicting social media user’s intention to verify news before sharing on social media.
Voice or silence: antecedents of whistleblowing intentions
Authors: Iwai Tatiana , Yeung Luciana , Artes Rinaldo 
Published: March 2021

Purpose
This study aims to examine the effects of peer ethical behavior and individual differences in valuation of fairness vs loyalty on whistleblowing intentions in academic settings. This study also tests the underlying mechanism responsible for the effects of peer behavior on reporting intentions, namely, fear of reprisal.

Design/methodology/approach
A survey was conducted with 947 undergraduate students. The model was tested using ordinary least squares regression models followed by bootstrapped mediation analyses.

Findings
Results showed that the effects of peer ethical behavior on whistleblowing intentions are mediated by fear of retaliation. Moreover, the findings indicated that, for low-severity transgressions, there is an interactive effect between fear of retaliation and endorsement of fairness over loyalty on whistleblowing intentions.

Research limitations/implications
When the misconduct is seen as minor, a potential whistleblower may understand that the expected costs outweigh the possible benefits of blowing the whistle. In such situations, higher fear of retaliation would undermine the effects of individual’s endorsement of fairness over loyalty on reporting intentions.

Practical implications
As the social environment significantly affects someone’s whistleblowing intentions, there should be visible efforts to improve and to foster an ethical infrastructure in organizations.

Social implications
As fear of retaliation by peers is one of the most important determinants affecting the decision to report misconduct in general, there must be serious efforts from leaders to mitigate any threat of retaliation to those who come forward.

Originality/value
This work contributes to the discussion about individual and situational antecedents of whistleblowing. More importantly, it sheds light on one potential boundary condition for the influence of the fairness–loyalty tradeoff on whistleblowing decisions: severity of the transgression. The findings provide initial evidence that, for low-severity transgressions, fear of retaliation weakens the positive effects of one’s moral compass in terms of preference for fairness over loyalty on whistleblowing intentions.