bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fisetin Exerts Anti-tumorigenic Activity via Inhibition of Trypsin Activity in Colorectal Cancer
Authors: Li Lin , Wang Min , Liu Zheng , Huang Xiaoling , Li Yuting , Guo Jialiang , Jiang Zhengjin 
Published: March 2021

Abstract
Background: Colorectal cancer (CRC) is a malignant tumor with high incidence and bad prognosis. Therapies, which are more safety and effective, are urgent needed in clinical. Trypsin is proved to be crucial to cancer proliferation and migration, therefore, it’s possible to control cancers through modulating the activity of trypsin. Fisetin is a flavone with excellent trypsin inhibition that screened from more than 45 compounds derived from traditional Chinese medicine. However, the effects and the mechanisms of fisetin on CRC have not been well investigated. Methods: In this study, we firstly evaluated the expression of trypsin on CRC cells. The effects of fisetin on proliferation and migration of CRC cells were also investigated in vitro. The inhibitory effects on cell cycle and apoptosis were assayed using flow cytometry. The therapeutic activity and toxicity were evaluated in vivo. Results: Fisetin remarkably inhibited CRC cell proliferation and migration, as well as induced cell apoptosis and Go/G1 phase arrest in a dose‐dependent manner. Mechanistic studies revealed these effects were mediated partially through signaling pathways involving cell cycle regulators p21, p27, cyclinD1 and NF kappa B (NF-κB) p65. Administration of fisetin also significantly suppressed the tumor growth in tumor-bearing NOG mice inoculated with human HCT116 cells. Fisetin at the given dosage did not induce significant acute or chronic toxicity in rats.Conclusions: Fisetin can inhibit the growth and migration of CRC by inhibiting the trypsin both in vitro and in vivo. Our results revealed fisetin is a potent therapy for CRC.
SELECTION OF OPTIMAL AL–SI COMBINATIONS IN CAST IRON FOR CASTINGS FOR ENGINEERING PURPOSES
Authors: Frolova Liliia , Shevchenko Roman , Shpyh Alona , Khoroshailo Vadim , Antonenko Yana 
Published: March 2021

In this work, the optimal combinations of Al – Si in cast iron for cast parts for machine-building purposes were determined with the aim of subsequent selection of rational modes of modification and alloying, and the possibility of their implementation under industrial smelting conditions was checked.
The graphical dependence Si=f (Al) is obtained, which is a set of optimal combinations of the content of Al and Si in cast iron, providing the maximum ultimate tensile strength UTS≈245 ... 334 MPa.
The technological audit of the results of serial industrial smelting included the analysis of actual indicators, the calculation of sample distribution functions (mathematical expectation and dispersion) of the Al and Si content in the alloy, as well as the UTS value. The correspondence of the indicators of the content of Al and Si and the value of σ to the optimal values was assessed by testing the statistical hypotheses: H: M(Al)=Alopt, M(Si)=Siopt, M(σв)=σвopt.On the basis of the obtained results of the assessment of statistical characteristics and verification of hypotheses, it was established that at the chosen significance level α=0.05, the technological process of smelting satisfies the requirements of optimality in terms of the Si content, but in terms of the Al content, the technological process does not meet the requirements of optimality.
The proposed procedure for choosing the optimal combinations of Al and Si makes it possible to choose the amount of correcting additives depending on the actual indicators of the chemical composition during the smelting process. To do this, it is necessary to assess the closeness of the actual composition to the optimal curve Si=f(Al) and choose the one that most satisfies the criteria of rationality. The latter can be the cost of ferroalloys, through which Al and Si are introduced
ESTRATÉGIAS DEFENSIVAS EMPREGADAS POR CHEFIAS INTERMEDIÁRIAS DE UM HOSPITAL PÚBLICO FEDERAL DE ENSINO
Authors: Almeida Simone 
Published: March 2021

RESUMO
A pesquisa teve por objetivo analisar as estratégias defensivas empregadas por chefias intermediárias de um hospital público federal de ensino, utilizou-se a Psicodinâmica do Trabalho. Realizou-se uma pesquisa descritiva, de método misto por meio de estudo de caso. Estratégias defensivas individuais identificadas: conhecimento da instituição e sentimento de pertencimento; redimensionar a relevância dos problemas; estudar, fazer o que precisa ser feito; convívio familiar e atividade física; individualismo; servidão voluntária. Estratégias defensivas coletivas: conversa; motivação, apoio e oração em equipe; feedback; planejamento. Avaliação moderada a crítica para efeito da organização do trabalho e risco de adoecimento. Vivências de prazer: liberdade com a chefia para negociar e orgulho pelo trabalho exercido. Fatores de sofrimento: esgotamento emocional, estresse, sobrecarga. Danos físicos: alteração do sono, dores de cabeça, costas e corpo. Conclui-se que é preciso pensar em formas de minimizar os fatores de sofrimento uma vez que esses profissionais são o elo entre a direção as diversas categorias de trabalhadores e usuários.
PALAVRAS-CHAVE OU DESCRITORES: Trabalho. Chefias intermediárias. Estratégias defensivas.
Aspects of Communication and Organizational Competences Development Through Sport
Authors: Uspuriene Aiste Barbora , Sadzevichiute Deimante 
Published: March 2021

Sport has a great impact on a person, as it develops mental and physical skills, forms the worldview, patriotism, awareness, creativity of children and adolescents, which can successfully integrate into the modern environment. Research aim – to analyze the literature and to reveal aspects of communication and organizational competences development through sport.
DIGITALIZATION PROCESSES DEVELOPMENT IN ASEAN REGIONAL INTEGRATION ASSOCIATION
Authors: Mirakyan D. G. 
Published: March 2021

The expansion of the Association of Southeast Asian Nations (ASEAN) economic capacity appears to be driven by digital factors. Current research analyses the digitalization processes in ASEAN, determines the digitalization strategy for the integration block, provides with the relevant dynamics of digitalization level indicators. The analysis of digital indicators revealed the rapidly growing level of dissemination of information and communication technologies and the dynamic development of the digital economy as a whole. Despite ASEAN's digital potential, a number of problematic issues remained, such as government regulation, protection against digital fraud, and protection of intellectual property rights. A successful initiative for the digitalization development in the Asian Pacific region could be the development of an appropriate legal framework, the development of transport infrastructure, the public-private partnership tools usage and budgetary incentives. For ASEAN member countries leadership in the digital race it seems advisable to organize training sessions, create jobs in digital industries, develop social impact bonds (SIB) projects, and create a global digital ecosystem.
IMPACT OF THE COVID - 19 PANDEMIC ON THE GLOBAL VIDEO GAMES MARKET
Authors: Burdenko E. V. , Shchepetov V. V. 
Published: March 2021

The article focuses on the analysis of the global video game industry. The structure of the gaming industry, which includes manufacturers from around the world, is considered. The study showed the controversial impact of the COVID-19 pandemic on the global video game industry. The units of the global video games industry affected by the introduction of quarantine measures and self-isolation have been highlighted: cancelation or postponement of the events to 2021. Among the positive changes are the following: increased sales of video games, an increase in the number of users and the number of hours of online games. During the research, general scientific methods were used: analysis, synthesis, classification, historical method. The quantitative method was used to analyze the dynamics of economic indicators of the global video game market. The graphical presentation made it possible to visualize the obtained data. The source of information during the research was monographs and articles of foreign and domestic scientists; data from analytical agencies in the field of video games in the world; Internet resources specializing in market analysis and consumer behavior; analytical data of the World Economic Forum, etc. The scientific novelty of the study consists in a comprehensive analysis of the gaming industry, which has not been conducted before, in the unprecedented conditions of the COVID-19 pandemic.
ECONOMIC AND SOCIAL UPGRADING OF DEVELOPING COUNTRIES IN GLOBAL VALUE CHAINS
Authors: Volkova K. S. 
Published: March 2021

The issue of overexploitation in developing countries in the era of Global value chains (GVC ) is directly related to the question of the relationship between the economic and social upgrading of countries in GVC. The relevance of this topic is due to its narrow representation in the scientific field, as well as the persistence of a low standard of labor force’s living in developing countries, despite the growth in labor productivity and the transition to the production of goods with higher added value. This article examines the problems faced by low-and medium-skilled workers in developing countries, including extremely low wages, social insecurity, and gender inequality. Often the reason for the preservation of this situation is the low price of goods, which is set by the purchasing companies that govern the GVC. International organizations and the media systematically attract public attention to this problem, which has led to the establishment of control over working conditions by the parent companies of the GVC. However, in many industries, the workers’ situation is still unsatisfactory, which indicates that the measures taken in this direction are insufficient. According to the author, significant improvement of working conditions is difficult without the participation of industry and inter-industry trade unions of employees.
Abraham versus Jacob
Authors: Lemański Janusz 
Published: March 2021

This article deals with the formation process of the traditions concerning the three patriarchs from the book of Genesis. It can already be stated that the traditions of Abraham, Isaac, and Jacob were initially formed independently of one other. The chronological priority should be assigned to the tradition of Jacob. It was originally combined with the tradition of Isaac (in Amos), and before the exile it constituted the earliest point of reference for the search of roots and identity. It was only towards the end of the exile that the particular time and situation resulted in the local, Judaean traditions of Abraham starting to play a greater role also in the theological aspect. Abraham became then not only a model of faith, and an example of behaviour for the exiles and the repatriates, but also the first link in the chain of the three patriarchs. Some motifs in the story of Abraham may have been at that time borrowed from the traditions of Isaac (cf. Gen 26).
Effect of Anti-Retroviral Drug Impurity/Related Substances on the CCR5 and/or CXCR4 Receptors Binding Sites to Revise Resistance Mechanisms in the Clinical Implications Using Molecular Docking Studies
Authors: Bora Rinchi , Jeyaprakash M.R. , Jubie S. 
Published: March 2021

Background:
CCR5 and/or CXCR4 receptors on CD4+ T cell membranes are the active
sites for HIV to bind. The different classes of drugs have a unique mechanism of action to cease the
virus, but we are concentrating in the first-class i.e. NNRTI that destroys the virus while it binds to the
cell surface gp120 protein. The drugs are having several impurities that can be genotoxic and few are
reported in the monographs.

Objective:
This study proposes the affinity of the impurities to the active site through molecular docking
to a receptor (PDB ID 4MBS) from the library of analogs available for antiretroviral drugs. As
these drugs are taken for the long term, this study will give a prominent idea for testing the impurities
and their genotoxicity.

Method:
We have done molecular docking of 37 impurities and drugs with the GLIDE module of
schrodinger software for their binding affinities. In this study, receptor CCR5 and/or CXCR4 is selected
containing glycoprotein that mediates virus binding to CD4+ T cell.

Results:
Didanosine E and Zidovudine D shows maximum and minimum score respectively. The selected
impurities were interfering with the active binding site that may lead to any ADR or reduce the
effect of API.

Conclusion:
Conclusively, a significant role is played by Protein-Ligand interaction in structuralbased
designing. Summarizing that there might be a genotoxicity effect due to competition between
API and the impurities. The molecular docking was used to study the binding mechanism and to establish
the docking score along with the activity. The outcome of the study can be used to design and development
of novel compounds having genotoxicity.
Usability of a Co-designed eHealth Prototype for Caregivers: Combination Study of Three Frameworks
Authors: Tremblay Melanie , Latulippe Karine , Guay Manon , Provencher Véronique , Giguère Anick , Poulin Valérie , Dubé Véronique , Giroux Dominique 
Published: March 2021

Background
Co-design (or the participation of users) has shown great potential in the eHealth domain, demonstrating positive results. Nevertheless, the co-design approach cannot guarantee the usability of the system designed, and usability assessment is a complex analysis to perform, as evaluation criteria will differ depending on the usability framework (or set of criteria) used. ISO (International Organization for Standardization) on usability (ISO 9241-210), Nielsen heuristic, and Garrett element of user experience inform different yet complementary aspects of usability.

Objective
This study aims to assess the usability and user experience of a co-design prototype by combining 3 complementary frameworks.

Methods
To help caregivers provide care for functionally impaired older people, an eHealth tool was co-designed with caregivers, health and social service professionals, and community workers assisting caregivers. The prototype was a website that aims to support the help-seeking process for caregivers (finding resources) and allow service providers to advertise their services (offering resources). We chose an exploratory study method to assess usability in terms of each objective. The first step was to assess users’ first impressions of the website. The second was a task scenario with a think-aloud protocol. The final step was a semistructured interview. All steps were performed individually (with a moderator) in a single session. The data were analyzed using 3 frameworks.

Results
A total of 10 participants were recruited, 5 for each objective of the website. We were able to identify several usability problems, most of which were located in the information design and interface design dimensions (Garrett framework). Problems in both dimensions were mainly coded as effectiveness and efficiency (ISO framework) and error prevention and match between the systemand the real world (Nielsen heuristic).

Conclusions
Our study provided a novel contribution about usability analysis by combining the 3 different models to classify the problems found. This combination provided a holistic understanding of the usability improvements needed. It can also be used to analyze other eHealth products.

International Registered Report Identifier (IRRID)
RR2-10.2196/11634
Overbidding in Mergers and Acquisitions: An Accounting Perspective
Authors: Bartov Eli , Cheng C. S. Agnes , Wu Hong 
Published: March 2021

ABSTRACT
Does accounting regime play a role in the well-documented phenomenon of overbidding in M&As? The 2001 regulatory change from a goodwill amortization to a non-amortization regime (SFAS 142) affords us a quasi-experimental setting for testing the consequences of M&A accounting rules for acquirers' bidding decisions. Relying on a novel approach to modeling optimal bidding, our primary finding indicates a significant increase in overbidding in the post-2001 period, suggesting that M&A accounting has real consequences for bidding decisions, and that this result is robust to a battery of sensitivity tests. In addition, supplementary tests show that overbidding is more pronounced in pooling versus purchase transactions, and that the accounting regime's implications for overbidding and acquisition premium are distinct. Overall, our findings shed light on the role accounting plays in shaping managerial decisions—and, ultimately, shareholder wealth—in an important corporate setting. They may thus inform researchers, corporate boards, and standards setters.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: G34, M41.
Suomalaisten luottamus instituutioihin ja asiantuntijoihin COVID19-pandemiassa
Authors: Jallinoja Piia , Väliverronen Esa 
Published: March 2021

Tässä tutkimuksessa selvitämme suomalaisten luottamusta instituutioihin, asiantuntijoihin ja uutismediaan koronakriisin käsittelyssä sekä yksilön vapauteen ja vastuuseen liittyviä asenteita huhtikuussa ja kesäkuussa 2020. Tulosten mukaan suomalaiset luottivat varsin vahvasti hallitukseen, viranomaisiin sekä THL:n ja yliopistojen tutkijoihin kriisin käsittelyssä. Samoin Yle Uutisiin ja MTV Uutisiin luotettiin kriisin raportoinnissa. Enemmistö vastaajista pyrki noudattamaan viranomaisohjeita ja hyväksyi yksilöiden vapauksien rajoitukset epidemian hallitsemiseksi. Enemmistö piti koronarokotuksista kieltäytyjiä vastuuttomina, mutta samalla enemmistö uskoi, että koronarokotusten tulisi olla vapaaehtoisia. Tutkimme tarkemmin sitä, ketkä luottivat eniten ja ketkä vähiten mainittuihin tahoihin. Naiset suhtautuvat miehiä myönteisimmin THL:n toimintaan ja Yle Uutisiin, miehet puolestaan sosiaalisen median vaikuttajiin. Perussuomalaiset erosivat lähes kaikkien muuttujien suhteen muista puolueista: he olivat kriittisimpiä THL:ää, STM:ää, Yle Uutisia sekä viranomaisten rokotetietoa kohtaan. Lopuksi pohdimme, miten voimme näiden tulosten valossa tulkita väitteitä tieteen ja asiantuntijoiden arvostuksen laskusta. Pohdimme myös sitä, muuttiko koronakriisi suomalaisten suhtautumista kansallisiin instituutioihin.
The Effectiveness of FEFA in Teaching and Learning Foundations of Applied Mathematics
Authors: Sarudin Ezzah Suraya , Omar Nor Alwani binti Omar , Mat Saleh Syadatul Syaeda 
Published: March 2021

Memorizing formulas is one of the essentials tasks in learning activities. There are many formulas that have been constructed by previous researchers. The formulas developed have their own purpose such as to calculate, to estimate, to analyse and so on. One of the fields that involve more than a hundred formulas is in the education field. In education area, especially for mathematics subjects, students need to memorize the formula to let them easily get the answer to some of the questions given. In UiTM Perak Tapah Campus, there is one subject that requires students to memorize more than twenty formulas. The subject namely the Foundation of Applied Mathematics which is taken by part three students in the Faculty of Applied Sciences. In previous semester, the failure rate for this subject is increasing and always be the top issue by top management. In this paper, the effectiveness of formula extracted from the given Appendix (FEFA) techniques is discussed. FEFA is one of the tools which will help students to reduce the total number in memorizing the formula. Primary data were gathered using the Quizizz application among 81 students who are taking MAT238 in the semester September-December 2019. The data was analysed by mixed design analysis to assess the effectiveness between pre-workshop and post-workshop. FEFA is found to be one of the good mechanisms to assist students in learning activities.
A rare hepatic abscess by Streptococcus intermedius complicated with hepatobronchial fistula: a case report
Authors: De Santiago Valenzuela José Martin , Pineda Galindo Luis Francisco , Guerrero Mancinas Zeltzin Olivia , Castro Ponce Ana Belem Clotilde , Degante Carlos Fitzner 
Published: March 2021

Background:
Hepatobronchial fistula is infrequent and secondary to pyogenic abscess caused by Streptococcus intermedius. This agent causes infections such as hepatic abscesses, endocarditis, bacteremia, and others. The treatment includes drainage, antibiotic management, and surgical intervention in some cases.

Case Presentation:
We describe a case of a 50-year-old male with a pyogenic liver abscess complicated by hepatobronchial fistula, admitted to the Internal Medicine Department with fever, long-lasting chills, and weight loss. The diagnostic approach revealed a pyogenic abscess secondary to S. intermedius. After percutaneous drainage, the patient presented purulent expectoration. A cavitogram revealed a hepatobronchial fistula. Treatment with antibiotics and closure of the defect was satisfactory.

Conclusion:
This is a case of a hepatic abscess due to S. intermedius complicated with hepatobronchial fistula, a rare clinical entity; the opportune hybrid approach (surgical plus interventional and radiological) reduces the risk of a major thoracoabdominal operation, which influenced the good prognosis of our patient.
Comparison of proximal femoral nail and hemiarthroplasty outcomes in elderly (over 80 years old) patients with intertrochanteric fractures
Authors: ŞİŞMAN Ali , ŞAVK Şevki , ÇEPNİ Serdar 
Published: March 2021

Aim: Proximal femoral nail (PFNA) and hemiarthroplasty are the two most frequently used methods in the surgical treatment of intertrochanteric femur fractures. The study aimed to determine the priority choice for surgical treatment in elderly patients (over 80 years old).
Methods: Patients treated for intertrochanteric femur fractures between 2012 and 2017 were retrospectively analyzed. Patients aged 80 years and over who were treated with hemiarthroplasty or PFNA were included in the study. Length of the operation, need for postoperative intensive care, Harris Hip Score, postoperative complications, and mortality rates in the first year were compared.
Results: A total of 120 patients with intertrochanteric femur fractures older than 80 years were evaluated. There were 43 patients (35.8) in the hemiarthroplasty group and 77 (64.2) in the PFNA group. No significant differences were found between the two groups in terms of mortality, need for postoperative intensive care, Harris Hip Score, and postoperative complications in the first year. While the median operation time was 45 minutes (IQR 40-50) in the PFNA group, it was 80 minutes (IQR 75-85) in the hemiarthroplasty group (p