bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of combination of 7% hypertonic saline and 0.1% natrii hyaluronas in patients with chronic obstructive pulmonary disease who have suffered a new coronavirus infection
Authors: Titova O. N. , Kuzubova N. A. , Skliarova D. B. , Aleksandrov A. L. , Egorova N. V. 
Published: November 2021

Introduction. New coronavirus infection (COVID-19) contributes to the aggravation of respiratory symptoms in patients with COPD, including affecting the intensity and nature of cough. Hypertonic solution (HS) has a positive effect on the rheological properties of sputum and mucociliary clearance. However, there are no studies in the available literature on the use of HS in patients who have undergone COVID-19.Goal. To evaluate the effect of the combination of 7% hypertonic saline and 0.1% natrii hyaluronas on the intensity and productive nature of cough in patients with COPD who have undergone a new coronavirus infection and the safety of its use in this cohort of patients.Materials and methods. 50 patients with severe COPD in remission who suffered a new coronavirus infection were examined. The rehabilitation stage of treatment was carried out in the conditions of the pulmonology department. From the moment of receiving the last negative PCR result for SARS-CoV-2 to admission to the hospital for rehabilitation, it took from 2 to 3 weeks. The duration of follow-up of patients was 10 days. The patients were divided into two groups: group 1 (n = 25) – patients who received combination of 7% hypertonic saline and 0.1% natrii hyaluronas 7% by inhalation through a nebulizer; group 2 (n = 25) – patients who did not receive combination of 7% hypertonic saline and 0.1% natrii hyaluronas. The severity of cough was assessed (cough severity scale; shortness of breath, cough and sputum scale), clinical and biochemical blood tests, ECG, spirometry.Results. In patients treated with combination of 7% hypertonic saline and 0.1% natrii hyaluronas, a significant decrease in the severity of cough, the amount of sputum was revealed. The tendency to reduce shortness of breath and improve the quality of life is determined. No serious adverse events were detected when using the drug.Conclusions. The use of the combination of 7% hypertonic saline and 0.1% natrii hyaluronas in patients with COPD who have suffered a new coronavirus infection at the rehabilitation stage leads to a decrease in the intensity of cough and improved sputum discharge, which helps to reduce the severity of shortness of breath and improve the quality of life. The use of the drug is safe and does not lead to clinically significant adverse events.
In-silico Exploration of Phytoconstituents of Gymnema sylvestre as Potential
Glucokinase Activators and DPP-IV Inhibitors for the Future Synthesis
of Silver Nanoparticles for the Treatment of Type 2 Diabetes Mellitus
Authors: Chavan Ajinkya , Daniel Kratika , Patel Ansar M. 
Published: November 2021

Background:
Diabetes has a large death toll worldwide, particularly as it falls into the ten
leading causes of death. Type 2 diabetes mellitus (T2DM) occurs as the body becomes resistant to insulin
and sugar accumulates in the blood. It has been observed that dipeptidyl peptidase-IV (DPP-IV) inhibitors
and glucokinase activators are known therapeutic agents to treat T2DM. Among the possible
medicinal plants, Gymnema sylvestre (GyS) belongs to the Apocynaceae family and is traditionally used
for the treatment of different diseases. This plant is also known as “Gurmur” because it has a sugarreducing
ability. GyS is known to be one of the main botanicals for the treatment of diabetes.

Objective:
Considering the studies described above, we have tried to investigate the natural DPP-IV inhibitors
and potent glucokinase activators from the phytoconstituents of GyS. New drug candidates from
the medicinal plant GyS have been reported as potent DPP-IV inhibitors and glucokinase activators.

Methods:
As a preliminary investigation, we have studied the effectiveness of phytoconstituents of GyS
in T2DM through molecular docking as a proof of concept of synthesizing silver nanoparticles (for the
treatment of T2DM) using an extract of this plant.

Results:
The present investigative research shows that the recognized compounds included in the present
analysis have important values in the treatment of diabetes mellitus. The nine compounds selected
are evaluated on the basis of DPP-IV and glucokinase enzyme binding energy values and their drug
properties. Except for quercitol, all the selected compounds have exhibited much more potent glucokinase
activation potential than their native ligands. Gymnemasin A, lupeol, gymnemoside A, gymnemasaponin
V, and gymnemic acid I have shown excellent DPP-IV inhibitory potential.

Conclusion:
We aimed to synthesize the silver nanoparticles from the leaf extract of GyS for the treatment
of T2DM. As a preliminary investigation, we have studied the effectiveness of phytoconstituents
of GyS in T2DM through molecular docking as proof of synthesizing silver nanoparticles (for the treatment
of T2DM) using an extract of this plant. As a result of the present investigation, it has been concluded
that these compounds can be used to treat T2DM, and hence, in the future, we can synthesize the
silver nanoparticles from the GyS extract for the treatment of T2DM.
Ethnobotanical Review of Medicinal Plants Used Against Diarrhea and Dysentery
in Northeast India (Assam)
Authors: Gam Sameeran , Deka Dhiren , Das Biswajit , Sarma Dhrubajyoti , Kumar Suman , Kushari Susankar , Saikia Arundhati , Sarma Himangshu 
Published: November 2021

Background:
Since primitive times, plants have been extensively utilized in conventional remedies for primary health care. It is observed that medicinal plants have various bioactive components. It becomes an alternative choice for synthetic medications to treat diarrhea and dysentery, which are the primary waterborne diseases with high mortality rates that bring substantial health threats to global populations.

Objective:
The present review aims to look over the ethnobotanical knowledge for the treatment of diarrhea and dysentery and folklore practices by the people prevailing in Assam.

Methods:
In this perspective, an extensive literature survey was carried out to understand the mechanism, control, and treatment of diarrhea and dysentery in different online academic databases and books. An advanced search was carried out in 'PubMed' and 'Google Scholar' using the term "Phytoconstituents" and "antidiarrheal" along with "Phytoconstituents" and "anti-amoebic".

Results:
Data retrieved from databases were analyzed and interpreted to conclude that in Assam, diarrhea and dysentery are the primary leading causes of mortality among children under five years. It is mainly due to the unhygienic livelihood, unavailability of safe drinking water, unhealthy food, seasonal rainfall, flood, and open defecation. The present investigations reveal that the people of Assam use 39 plant species belonging to 36 families to cure diarrhea and dysentery.

Conclusion:
The present study established the effective use of medicinal plants by various communities in Assam to treat diarrhea and dysentery. Furthermore, it can be used to develop a new therapeutic approach to create new chemical entities (NCE) in drug discovery, which are safe, fruitful, and inexpensive.
Comparative analysis: to and ni as case particles in Japanese
Authors: Pradhana Ngurah Indra , Oeinada I Gede 
Published: November 2021

This study focuses on particles To and Ni as case particles that function to express the relationship between nouns and predicates in a sentence focusing on the comparative analysis of the two case particles. Based on Tsujimura's opinion, it can be said that in Japanese, case particles are part of a phrase. Case particle is related to the function of the words in the sentence. The method used to analyze the data is Agih method (distributional method). Advanced analysis techniques with substitution techniques were applied in this study. This technique is used to study a case particle in the Japanese sentence structure. This research produces several things that are expected to be helpful to readers. To and Ni case particles can replace each other for the context of sentences that have the following meanings: Pairs Meaning, Translative Meaning, Accusative Meaning, and Ablative Meaning. But on the other hand, To and Ni as case particles can not substitution each other. Especially sentences with the following meanings: accusative meaning, commitative meaning, partner meaning, citation meaning, alatif meaning, purpose meaning, time markers meaning, diathesis on passive sentences, diathesis on causative sentences, dative meaning, and locative meaning.
Translating Islamic identity into numbers
Authors: Maseleno Andino , Huda Miftachul , Marzuki Mazdi , Leh Fauziah Che , Hashim Azmil , Ibrahim Mohd. Hairy 
Published: November 2021

This research aims to define various Islamic based identity profile to different individuals by identifying the various degrees of Islamic based identity profile. A scale of measurement in ordinal scale has been used to determine an Islamic based identity profile. The scale is subdivided into three main subsections, namely very rarely, average level and very frequently. By using the scale of measurement on an ordinal scale, it assists in developing a numerical hypothesis that is then used to determine an individual's Islamic based identity profile using the Dempster-Shafer theory of evidence. Using twenty-four set of questions, the research used the evidence presented to support a given Islamic based identity profile of a specific individual and filtered it using various degrees of probabilities of the evidence theory model, which have aided in proving or validating a particular hypothesis. The questions are divided into three types based on Islamic identity profile which include Fitrah, Khalifah and Din. The conclusion made is that we may be able to easily diagnose an individual’s Islamic based identity profile using Dempster-Shafer theory of evidence.
Academization of bandura by bandurism exponents in Ukraine
Authors: Zinkiv Iryna Ya. 
Published: November 2021

Ukrainian bandura underwent a long and difficult evolutionary path. Its academicization process took place in the XX-XXI centuries. The impact of prominent bandura craftsmen O. Korniievskyi, V. Tuzychenko, I. Skliar, and V. Herasymenko on the process of the Ukrainian bandura academization was studied. The authors devoted their work to historical assessment in the affirmation of the academized instruments of Chernihiv (or Kyiv-Chernihiv) and Kharkiv types. The specifics of the creation of the academized instrument in 1920–2010 by leading Ukrainian designers – bandura craftsmen became a purpose of the study. The abovementioned bandura craftsmen made a significant impact on the academization of diatonic banduras, their transformation into the instrument with a double-diatonic tuning system and bringing it closer to European trends. The particular roles of O. Korniievskyi, V. Tuzychenko, I. Skliar, and V. Herasymenko in this process were characterized. It was noted that the Kyiv method of play on an academic instrument is much more popular than Kharkiv-type which is why the latter needs additional attention.
Predictive Modeling of Vaccination Uptake in US Counties: A Machine Learning–Based Approach
Authors: Cheong Queena , Au-yeung Martin , Quon Stephanie , Concepcion Katsy , Kong Jude Dzevela 
Published: November 2021

Background
Although the COVID-19 pandemic has left an unprecedented impact worldwide, countries such as the United States have reported the most substantial incidence of COVID-19 cases worldwide. Within the United States, various sociodemographic factors have played a role in the creation of regional disparities. Regional disparities have resulted in the unequal spread of disease between US counties, underscoring the need for efficient and accurate predictive modeling strategies to inform public health officials and reduce the burden on health care systems. Furthermore, despite the widespread accessibility of COVID-19 vaccines across the United States, vaccination rates have become stagnant, necessitating predictive modeling to identify important factors impacting vaccination uptake.

Objective
This study aims to determine the association between sociodemographic factors and vaccine uptake across counties in the United States.

Methods
Sociodemographic data on fully vaccinated and unvaccinated individuals were sourced from several online databases such as the US Centers for Disease Control and Prevention and the US Census Bureau COVID-19 Site. Machine learning analysis was performed using XGBoost and sociodemographic data.

Results
Our model predicted COVID-19 vaccination uptake across US counties with 62% accuracy. In addition, it identified location, education, ethnicity, income, and household access to the internet as the most critical sociodemographic features in predicting vaccination uptake in US counties. Lastly, the model produced a choropleth demonstrating areas of low and high vaccination rates, which can be used by health care authorities in future pandemics to visualize and prioritize areas of low vaccination and design targeted vaccination campaigns.

Conclusions
Our study reveals that sociodemographic characteristics are predictors of vaccine uptake rates across counties in the United States and, if leveraged appropriately, can assist policy makers and public health officials to understand vaccine uptake rates and craft policies to improve them.
Eating disorders: Reflecting on the sociocultural variables / Trastornos de la conducta alimentaria: Reflexionando en torno a las variables socioculturales
Authors: Cruzat Mandich Claudia V. , Haemmerli Delucchi Constance V. , García Troncoso Andrea L. 
Published: October 2021

Abstract. Eating disorders (ED) are illnesses that had awakened enormous interest in social and health media in the last years. Thus now days, it is spoken of authentic epidemics, in which the diagnosis is late, existing multiple management difficulties and numerous risks in their development. This article aims to install a reflection on the importance of a socio-cultural context, since cultural beliefs and values associated to beauty and food would be linked to the subjectivity that surrounds this disease. In this sense, the characteristic symptoms of this disorder occur in a cultural reference framework that has to be analyzed. Key words: Eating Disorders, treatment, culture. Resumen. Los trastornos de la conducta alimentaria (TCA) son enfermedades que han despertado, en los últimos años, enorme interés en medios sociales y sanitarios. En la actualidad se habla de auténticas epidemias, donde el diagnóstico es tardío, existiendo múltiples dificultades de manejo y numerosos riesgos en su evolución. Este artículo tiene como objetivo instalar una reflexión en torno a la importancia de rescatar el contexto sociocultural, ya que las creencias y valores culturales asociados a la belleza y a la comida, estarían vinculados a la subjetividad que rodea dicha patología. En ese sentido, la sintomatología característica de este trastorno se da en un marco referencial cultural importante de ser analizado. Palabras clave: Trastornos alimentarios, tratamiento, cultura.
PERAN MODERASI MINDFULNESS DALAM HUBUNGAN ANTARA INTENSITAS PENGGUNAAN INSTAGRAM DAN KESEPIAN PADA DEWASA MUDA
Authors: Salsabila Tyas Apti , Sahrani Riana 
Published: November 2021

Loneliness is a feeling of emptiness that a person feels as a result of a lack of intimacy with others. The development of social media technology is also one of the factors that affect a person's loneliness. Results from previous research have shown that the use of social media can make a person lonely. To reduce feelings of loneliness, one must have mindfulness. The purpose of this study was to test the role of mindfulness moderation against the intensity of relationships of Instagram use and loneliness. The research uses non-experimental quantitative methods. Measuring instruments used in this study are UCLA Loneliness scale version 3, Instagram usage intensity measuring instrument, and Kentucky Inventory of Mindfulness Skills. The participants of this study were 544 people who are Indonesian residents aged 20-40 years active users of Instagram.The results of this study show that there is no significant relationship between the intensity of Instagram use and loneliness, so the role of mindfulness moderation cannot be proven. Kesepian merupakan perasaan hampa yang dirasakan seseorang akibat dari kurangnya keintiman dengan orang lain. Perkembangan teknologi sosial media juga menjadi salah satu faktor yang memengaruhi rasa kesepian seseorang. Hasil dari penelitian sebelumnya menunjukkan bahwa penggunaan sosial media dapat menyebabkan seseorang menjadi kesepian. Untuk mengurangi perasaan kesepian, seseorang harus memiliki kesadaran dan sikap mindfulness. Tujuan penelitian ini adalah ingin menguji peran moderasi mindfulness terhadap hubungan intensitas penggunaan Instagram dan kesepian. Penelitian menggunakan metode kuantitatif non-eksperimental. Alat ukur yang digunakan pada penelitian ini adalah UCLA Loneliness scale version 3, alat ukur intensitas penggunaan Instagram, dan Kentucky Inventory of Mindfulness Skills. Partisipan penelitian ini sebanyak 544 orang yang merupakan penduduk Indonesia berusia 20-40 tahun pengguna aktif Instagram. Hasil penelitian ini menunjukkan bahwa tidak terdapat hubungan signifikan antara intensitas penggunaan Instagram dan kesepian, sehingga peran moderasi mindfulness tidak dapat dibuktikan.
The Poldnevskoye deposit of demantoid (Middle Urals): Geology and mineralogy
Authors: Karaseva E. S. , Kissin A. Yu. , Murzin V. V. 
Published: November 2021

Research subject. The results of studying the geology and mineralogy of the Poldnevskoye deposit of demantoid are presented. Material and methods. The factual material was collected during feld research. Demantoid samples were pro vided by mine owners. Rock and vein minerals were studied in hand specimens, polished specimens and thin sections; the chemical composition was determined by X-ray ﬂuorescence spectroscopy, scanning electron microscopy, electron probe X-ray spectral microanalysis, inductively coupled plasma mass spectrometry with laser sampling (LA-ICP-MS).Results. The Korkodinsky ultrabasic massif containing the deposit experienced strong decompression and syndecompression mineral formation during the ascent. At an early stage, veins of clinopyroxenite formed in dunite, which also experienced decompression cracking. Then the rocks underwent antigoritization and the appearance of vein antigorite, which was replaced by veins of clinochrysotile (+ magnetite ± carbonate ± demantoid). This was followed by the formation of lizardite (+ magnetite ± carbonate ± demantoid), which also developed along the earlier vein serpentines. Demantoid is represented by rounded grains and rounded grain aggregates with the signs of growth under the conditions of allround extension. The predominant color is brownish-green, yellow-green, rarely green and dark green. Green and dark green demantoids contain Cr2O3 0.52–2.3 wt %. In the central part of some grains and demantoid aggregates, a brown color is observed, which binds to TiO2, the content of which reaches 1 wt %. The demantoids of the Poldnevskoye deposit bear typomorphic features of the Ural-type demantoids (inclusions of the “horse’s tail” type). The distribution of demantoid is nested. The length of the veins with demantoid is frst meters. Their pillar-like shape is assumed. Conclusion.Demantoids from nests in serpentinized massive or brecciform dunites are more intact; demantoid nests in strongly serpentinized rocks were tectonic crushed and contain little gemstone.
In Vitro Effects of Different Combinations of Phytohormones on Callus Induction from Different Explants of Cabbage Brassica Oleracea Var. Capitata L. Seedlings
Authors: Hasan Alaa. M. , ElKaaby Ekhlas. A.J. , AL-Jumaily Rakad. M.Kh. 
Published: November 2021

The leading purpose of this work is the development of efficient culture conditions to induce calli from cabbage (Brassica oleracea var. capitata L.) under in vitro conditions. The mature seeds were surface sterilized with combinations of different concentrations of ethanol and NaOCl in different time durations and were germinated on MS basal medium. The results revealed that the best sterilization method of cabbage seeds was by using 70% ethanol for one minute, followed by 15 min in 2% (NaOCl). Seedlings were used as donor sources for hypocotyls, cotyledon leaves, true leaves, and shoot tip explants. These explants were cultured on different combinations of cytokinins (TDZ, BAP, Ad) and auxins (IAA, NAA, 2, 4-D) then implanted in Murashige and Skoog (MS) media. 4 weeks after culturing, a significant difference was found among the explants in response to plant hormones. The maximum percentage of callus induction (100%) was using the combinations of 1 BAP + 1 2, 4-D, 1 BAP + 1 NAA, and 1 BAP + 2 2,4-D mg. l-1. In addition, explants responses varied and the hypocotyls showed a superior result (85.71 %) as compared to other explants. For callus fresh weight, the combination of 0.22 TDZ + 79.9 Ad mg. l-1 had a significant effect, causing the highest fresh weight (0.2745g), while control treatment gave the lowest mean of 0.0066 g. Data showed that cotyledon explants were significantly superior in giving highest callus fresh weight with the mean of 0.1723 g. On the other hand, hypocotyl explants gave the lowest mean, reaching 0.1542 g.
PENGARUH SUHU DAN WAKTU REAKSI TRANSESTERIFIKASI MINYAK JARAK KEPYAR (Castor Oil) TERHADAP METIL ESTER DENGAN MENGGUNAKAN KATALIS ABU TANDAN KOSONG KELAPA SAWIT
Authors: Lestari Lidya Permata , Meriatna Meriatna , Suryati Suryati , Suryati Suryati , Jalaluddin Jalaluddin 
Published: October 2021

Biodiesel merupakan bahan bakar alternatif untuk mesin diesel yang terdiri dari alkil monoester dari minyak tumbuhan atau lemak hewan. Minyak jarak kepyar (Castor Oil) adalah minyak nabati yang diperoleh dari ekstrak biji tanaman jarak kepyar. Tujuan dari penelitian ini adalah untuk memanfaatkan minyak jarak kepyar dalam pembuatan biodiesel dengan menggunakan katalis heterogen yang berasal dari tandan kosong kelapa sawit yang dikalsinasi pada suhu 600 °C selama 6 jam. Proses transesterifiksi mereaksikan minyak dan metanol untuk menghasilkan metil ester dan gliserol. Metil ester yang dihasilkan pada lapisan atas dipisahkan dari gliserol dan kemudian dimurnikan. Pengaruh dari berbagai variabel proses seperti pengaruh suhu dan waktu reaksi diamati dalam percobaan ini. Sifat-sifat biodiesel seperti Yield paling tinggi diperoleh pada suhu 65 °C selama 100 menit dengan katalis 3 (m/m)%.. yaitu sebesar 76,62%, kemudian untuk densitas diperoleh hasil terbaik 0,863 mg/l pada suhu 55°C selama 80 menit dengan katalis 3 (m/m)%, selanjutnya untuk viskositas diperoleh 5,25 mm2/s pada suhu 65°C selama 100 menit dengan katalis 3 (m/m)%, kemudian kadar air diperoleh 0,038%vol pada suhu 60°C dan selama 80 menit dengan katalis 3 (m/m)%. dan bilangan asam diperoleh 0,48 Mg-KOH/g pada suhu 50°C selama 100 menit dengan katalis 3 (m/m)%. Hasil yang diperoleh pada penelitian ini menunjukkan bahwa katalis yang berbasis tandan kosong kelapa sawit dapat digunakan untuk memproduksi biodiesel.