bluuebunny/crossref_metadata_2025_split huggingface dataset:
Betulin terpenoid targets OVCAR-3 human ovarian carcinoma cells by inducing mitochondrial mediated apoptosis, G2/M phase cell cycle arrest, inhibition of cell migration and invasion and modulating mTOR/PI3K/AKT signalling pathway
Authors: Yang Qin , Fei Zhiyi , Huang Chunyan 
Published: November 2021

The main purpose of the current research work was to study in vitro anticancer effects of betulin in OVCAR-3 human ovarian carcinoma cells along with examining its effects on cellular apoptosis, cell cycle phase distribution, cell migration and invasion and mTOR/PI3K/AKT signalling pathway. The cell proliferation of OVCAR-3 cells at various doses of the drug was studied by CCK8 cell viability assay. Effects on cell apoptosis were studied by fluorescence microscopy and western blot. Effects on cell cycle were evaluated by flow cytometry and western blot. Transwell assays were used to study effects on cell migration and invasion. The results indicated that betulin led to significant reduction of OVCAR-3 cell viability in a dose-dependent as well as time dependent manner. Betulin also led to reduction in cell colonies. The anticancer effects of betulin were due to the induction of apoptosis which was seen by increased apoptotic cells with yellow and orange fluorescence. Betulin prompted mitochondrial apoptosis which was also associated with alteration in the apoptosis-related protein expression (Bax, Bad and Bcl-2 and Bcl-xL). The molecule also led to G2/M phase cell cycle arrest on OVACR-3 ovarian carcinoma cells. It was also observed that betulin could inhibit the migration and invasion of the ovarian cancer cells in a concentration-dependent manner. Betulin molecule also resulted in blocking of mTOR/PI3K/AKT signalling pathway. In conclusion, this study clearly indicates the anticancer effects of betulin natural product in OVCAR-3 human ovarian cancer cells are mediated via apoptosis induction, G2/M phase cell cycle arrest, cell migration and invasion inhibition and targeting of mTOR/PI3K/AKT signalling pathway.
Prevalence of neoplasia in solitary and multiple esophago-gastrointestinal polyps: 5 years retrospective histopathological study
Authors: Mehdi Ahmed Hamdi 
Published: November 2021

The increasing use of endoscopy has led to more discernable abnormalities in the stomach, including polyps. Gastric polyps encompass a spectrum of pathologic conditions that can vary in histology, neoplastic potential, and management. Despite their high prevalence, there is a paucity of literature to support management and treatment decisions for endoscopists. The goal of this review is to summarize clinical, endoscopic, and histopathologic features of various polyps, review syndromes associated with such polyps and provide management recommendations. The present study was carried out for analyzing and comparing the prevalence of neoplasia in polyps (Solitary and multiple) removed endoscopically from the esophagus, stomach, and bowel undergoing screening. Five years retrospective study was done on patients who underwent endoscopy procedures including Oesophagogastroduodenoscopy (OGD) and colonoscopy between June 2015 and March 2019 in Faruk Medical City Hospital, Sulaimani City. Age and sex of patients, site of occurrence, number of polyps (solitary or multiple), and polyps' histologic type of 369 cases were analyzed in this study. Regarding solitary polyps, out of 279 polyps, 155 were neoplastic (55%) and 124 were non-neoplastic polyps, while multiple polyps, out of a total of 90 cases, 68 were neoplastic (75%) and 22 were non-neoplastic. More than 78% of patients were above the age of 40 years. Tubular adenoma was the most commonly diagnosed polyp. Large bowel was the most commonly involved site and left-sided polyps outnumbered right-sided ones with the sigmoid colon being the most commonly involved site. Screening programs including endoscopy, especially the colon for detecting polyps and particularly the colorectal region can be helpful to reduce morbidity and mortality of patients.
Jakub VI (I) Stuart w angielskiej przestrzeni religijnej
Authors: Basista Jakub 
Published: November 2021

The paper is concerned with the religious issues in England at the time when James VI Stuart, King of Scotland, ascended to the throne. The reign of the land dominated by the Anglican confession, with the king as the supreme head of the Church, going into the hands of a ruler who had grown up in a Presbyterian environment posed number of questions and challenges before the monarch and his subjects as well.
Numerical treatment of the generalized time-fractional Huxley-Burgers’ equation and its stability examination
Authors: Hadhoud Adel R. , Abd Alaal Faisal E. , Abdelaziz Ayman A. , Radwan Taha 
Published: November 2021

Abstract
In this paper, we show how to approximate the solution to the generalized time-fractional Huxley-Burgers’ equation by a numerical method based on the cubic B-spline collocation method and the mean value theorem for integrals. We use the mean value theorem for integrals to replace the time-fractional derivative with a suitable approximation. The approximate solution is constructed by the cubic B-spline. The stability of the proposed method is discussed by applying the von Neumann technique. The proposed method is shown to be conditionally stable. Several numerical examples are introduced to show the efficiency and accuracy of the method.
Exploring digital economy: a sociosemiotic perspective
Authors: Hu Ming , Hu Xitao , Cheng Le 
Published: November 2021

Abstract
Digital technologies have transformed our lives with unimaginable speed and scale, delivering immense opportunities and daunting challenges and leading to the birth of the digital economy. China and the United States (US) are two leading countries in the digital economy in both size and growth rate. This study employs both quantitative and qualitative methods to investigate the similarities and differences between the US and Chinese legislation from a sociosemiotic perspective. By comparing the high frequency words in the two purpose-built corpora, it can be noted that as digital economy, a social sign, has the characteristics of spatiality and temporality. The US federal legislation related to digital economy focuses more on security and protection and has more specific regulations in individual industries, while Chinese legislation is more concerned with the strategy and guideline of development of industries and technologies in digital economy. In the meantime, information infrastructure and information and communication technologies are identified as the foundation and core elements shared in the two countries’ digital economies. Such a corpus-based sociosemiotic exploration of digital economy can shed light on relevant studies in the discourse analysis of legal texts.
Propagation of dark-bright soliton and kink wave solutions of fluidized granular matter model arising in industrial applications
Authors: Sağlam Özkan Yeşim , Yaşar Emrullah 
Published: November 2021

Abstract
The improved tan(φ/2)-expansion, simplest equation, and extended (G′/G)-expansion methods are employed to construct the exact solutions involving parameters of the Van der Waals equation arising in the material industry. This model explains the phase separation phenomenon. Understanding the prominent dynamic and static properties of this model and other models of this type is of great importance for the physical phenomena encountered in many areas of industry. Therefore, for such models, it is also important to obtain guiding solutions in obtaining new information. Many explicit wave solutions consisting of trigonometric, hyperbolic, rational, and exponential functions are found by using analytical techniques. The obtained solutions were verified with Maple by placing them back into the original equations. Moreover, graphical demonstrations for some of the obtained solutions are given.
Investigations of wavelength division multiplexing-orthogonal frequency division multiplexing (WDM-OFDM) system with 50 Gb/s optical access
Authors: Kumar Gagandeep , Singh Kulwinder 
Published: November 2021

Abstract
In the present work, orthogonal frequency division multiplexing (OFDM) is combined with wavelength division multiplexing-passive optical networks (WDMPONs) to obtain the combined benefits of both technologies for overall system improvement. performance of five OFDM signals using WDM is analyzed. An optical system is designed using the OFDM signal, and its performance is analyzed using various matrices like bit error rate (BER) and Q-factor under the effect of varying laser power. Mapping of OFDM signals is done using 16-QAM modulation. The system shows an enhancement in the performance by increasing the laser power but up to some limit, and efficient results are obtained in the 70–130 mW laser power range.
Translanguaging pathways to higher education: a transition program for highly educated refugees
Authors: Duarte Joana , Günther-van der Meij Mirjam 
Published: November 2021

Abstract
The paper focuses on translanguaging practices of highly skilled refugees in a transition program in Dutch higher education. The pathways for refugees to enter higher education are full of obstacles. Acquiring the new language at a university level is one of the biggest challenges. Many institutions offer ‘transition programs’ to prepare refugees for their studies. These are mostly focused on acquiring language skills and general basic skills in subjects such as Mathematics and Cultural Diversity. The Dutch transition program described in this paper was specifically developed to make use of students’ multilingual repertoires. The resource-oriented pedagogy of translanguaging is used to give space to all languages, leverage students’ resources and contribute to their academic and language development. In this research, data from one year of the Dutch transition program was collected to study a) how teachers engage in official translanguaging practices during instruction and b) to what extent teachers develop other practices to engage with their students’ multilingual repertoires. Results from interaction analysis show that the teachers, although mainly using the language of instruction (Dutch), did use a variety of translanguaging practices, and created other ways to encourage students’ multilingualism, such as engaging in language comparisons and raising language awareness.
Low health-related quality of life in hypoparathyroidism and need for PTH analog
Authors: Kontogeorgos Georgios , Mamasoula Zoi , Krantz Emily , Trimpou Penelope , Landin-Wilhelmsen Kerstin , Laine Christine M 
Published: November 2021

Objective
Hypoparathyroidism (HypoPT) is a rare endocrine disorder in which insufficient levels of parathyroid hormone (PTH) lead to low serum calcium (S-Ca) levels and muscular cramps. The aim was to study the health-related quality of life (HRQoL) and comorbidities in patients with HypoPT compared with the general population and to estimate the need of treatment with PTH analog.

Design
Patients with HypoPT were identified and compared with a population sample. Short Form-36 (SF-36) and EuroQol-5 Dimensions Visual Analogue Scale questionnaires were used. All patients were followed up at the Sahlgrenska University Hospital outpatient clinic.

Methods
From the medical records between 2007 and 2020, 203 patients with HypoPT were identified and compared with a population sample (n = 414) from the World Health Organization’s (WHO) MONICA project, Gothenburg, Sweden. Of the 203 patients who met the diagnostic criteria, 164 were alive and 65% answered the HRQoL questionnaires.

Results
Patients with HypoPT, 80% postsurgical, and controls had similar age (60 years) and sex distribution (80% women). Patients had lower SF-36 summary component scores for physical (40.0 (interquartile range (IQR): 21) vs 51.2 (IQR: 14.6); P < 0.001) and mental (43.1 (IQR:17.4) vs 56.1(IQR:13.3); P < 0.001) well-being, irrespective of etiology or calcium levels. Individuals with HypoPT had more medications and lower renal function but not higher mortality than controls. Low HRQoL together with low calcium was present in 23% of individuals with HypoPT.

Conclusion
HRQoL was markedly lower in patients with HypoPT than in controls and independent of S-Ca levels. Treatment with PTH analog could be considered at least among patients with both low HRQoL and low calcium levels.
Vector control system of electric drive of grain machine conveyor
Authors: Burdilna Evgeniia , Serhiienko Sergii , Chornyi Oleksiy 
Published: November 2021

Purpose. Synthesis of an automatic control system for an asynchronous electric drive of a grain thrower conveyor based on a frequency converter with vector control.
Methodology. The research was carried out using methods of mathematical modeling of an electric drive; using methods of tuning optimization and regulator synthesis. The technique of synthesis of vector control systems is based on the representation of a non-stationary multi-connected object, which is an AC machine, in the form of a set of stationary subobjects with linear links in the main control channels.
Findings. The study of the work of the subordinate regulation system, which implements the principles of vector control, oriented along the vector of the rotor flux linkage, has been carried out. The modeling of the processes of AM excitation, AM start-up at idle speed, nominal load surge, speed reduction has been carried out. It was found that the synthesized system is characterized by good quality indicators. The overshoot at start does not exceed 5%, the regulation time is 0.4 s, the torque limitation is carried out at a predetermined level. It has been proven that oscillatory processes in transient modes with significant torque surges with classical settings of loop regulators can be compensated by introducing artificial cross-links into the control part of the electric drive.
Originality. A system of subordinate regulation of the blood pressure of the grain thrower trimmer conveyor has been implemented to set the speed of the grain flow with the aim of throwing grain at a given distance by creating an appropriate ballistic flight trajectory, which ensures a reduction in losses from damage to grain.
Practical value. The structure of the vector control system of a frequency-controlled asynchronous electric drive with additional compensating cross-connections between active and reactive energy control channels is proposed to improve the quality indicators of the system.
Microstructural analysis of the surface of implants removed in connection with periimplantitis
Authors: Ivanov Alexander S. , Maksyukov Stanislav Yu. , Olesova Valentina N. , Salamov Magomed Ya. , Martynov Dmitry V. , Olesov Egor E. 
Published: November 2021

BACKGROUND: The practice of prosthetics on implants shows a fairly high percentage of removed implants over the specified period. The reasons can be both insufficient hygiene of the tissues around the implants and their overload. Regardless of the cause, bone resorption occurs from the apex of the alveolar ridge (part) of the jaw deep into contact with the implant in combination with chronic inflammation of the periimplant soft tissues. Removal of the implant in such cases is indicated for bone resorption at half the length of the implant. Microstructural analysis of the surface of implants is rarely reflected in publications, since high-resolution microscopy is only possible for removed implants.
AIM: Microscopy and spectrometry of the surface of implants removed for periimplantitis.
MATERIALS AND METHODS: The surface analysis of the five implants removed due to periimplantitis was carried out by scanning electron microscopy in high vacuum mode with electron probe microprobe analysis of the elemental composition. A FEI Teneo VolumeScope single-beam scanning electron microscope with a detector was used to perform XFlash 6/30 energy dispersive analysis. The research was carried out in the Skolkovo Technopark.
RESULTS: The performed microscopic and spectrometric analysis, accompanied by micrographs and spectrograms of the cervical part of the implant in the area of bone tissue conservation, the presence of connective tissue and in the area of the exposed surface of the implant, demonstrate the process of disintegration of the implant due to periimplantitis, which consists in demineralization and resorption of bone tissue (in places up to the surface of the implant, in places with through defects to the surface of the implant) and its replacement with connective tissue.
CONCLUSIONS: Disintegration of the implant due to periimplantitis is accompanied by the process of demineralization and resorption of bone tissue (in places up to the surface of the implant, in places with through defects to the surface of the implant) and its replacement with connective tissue.
The revealing of some of causative microorganisms for sexually-transmitted diseases in chronic salpingoophoritis, bacterial vaginosis and nonspecific bacterial vaginitis
Authors: Ryshuk S. V. , Kostucheck D. F. , Boitsov A. G. 
Published: November 2021

The data on frequent combination of chronic inflammatory diseases of vagina and adnex can give the evidence for connection betzveen these pathologic processes.
The frequency of Mycoplasma hominis findings in patients with bacterial vaginosis points to their possible ethioloic role in the pathology. At the same time, vaginal smears presenting Ureaplasma urealyticum in patients zvith bacterial vaginosis indicates their role in formation of pathology.
One can suggest ethiologic mean of U.urealyticum in nonspecific bacterial vaginitis patients.
The evaluation of Mastodinon efficiency in treatment of hyperprolactinemic syndrome
Authors: Vishnevsky A. S. , Safronnikova N. R. , Melnikova N. U. , Grigorieva T. A. 
Published: November 2021

The clinical efficiency of Mastodinon (Bionorica) is studied in management of 33 patients (average age 34,6 years) with different menstrual disfunctions and dysmenorrhea. In 13 patients these disturbances coexisted with hyperprolactinemia.
As a result of 3-month treatment with Mastodinon we noted the normalization of menstrual function in 13 of 17 patients, and the decrease in prolactin serum levels on 10 of 13 women. The prolactin decrease was followed by increase in luteinizing hormone and progesteron, as chosen for ovulatory cycle.
It is found that Mastodinon has the properties of dopaminomimetics and can be concerned as the alternative for synthetic dopaminergic drug therapy (Bromocriptine etc.).
A comparative review of maternal and neonatal outcome among pregnant women with COVID-19 in first and second wave in a tertiary care centre of South Rajasthan
Authors: Chaudhary Divya , Chauhan Madhubala , Gupta Diksha , Jat Shivraj 
Published: November 2021

Background: Corona virus disease 2019 has taken a huge toll over health infrastructure and care all across the world. This article depicts our experience of COVID-19 in pregnant women and analyses maternal and neonatal outcome of same in first and second wave of this pandemic. Aim and objectives of the study were to compare the demographic characteristics, presenting features and fetomaternal outcome in COVID positive pregnant women in first v/s second wave in a tertiary care hospital.Methods: The RTPCR COVID-19 positive pregnant women admitted during the period April-2020 to March-2021 were considered in 1st wave of COVD-19 and that from April-2021 till June-2021 as 2nd wave of COVID-19. Data like baseline characteristics, past medical, obstetric history, clinical presentation, laboratory results, imaging findings, management modalities, maternal and neonatal outcome were analysed and compared.Results: Peak of 1st wave of COVID-19 was found during the months of July-September 2020, while of 2nd in April-June 2021. Most women presented with COVID-19 RTPCR positive were asymptomatic both in 1st and 2nd wave. Though most patients were managed on room air in both waves, 6.52% and 9.38% were on oxygen, 1.09% and 10.94% were managed with mechanical ventilation and BIPAP in 1st and 2nd wave respectively. There was significant (p<0.05) increase in maternal deaths in the 2nd wave (7.03%) as compared to 1st wave (1.09%).Conclusions: A significantly large number of patients were affected in 2nd wave of COVID-19 pandemic with more morbidity and mortality. Neonatal population remained relatively unaffected in both waves.
Correlation of laparoscopic finding with ultrasonography and hysterosalpingography findings in females with infertility
Authors: Arora Garima Bagga , Bodade Ritesh , Dhurve Asmita , Vaishnao Lohit S , Bagga Gourav 
Published: November 2021

Infertility is best defined as the inability to conceive after one year of unprotected regular intercourse or many couples, infertility and its treatment cause a serious strain on their interpersonal relationship, and cause disturbed relationships with other people.Diagnostic laparoscopy is generally not a part of initialinfertility evaluation, however, number of reports haveshown that it is effective procedure for evaluation of long- term infertility. A total of 207 patients were studied from at GMCH, Gondia, Maharashtra. Total 207 patients had primary/secondary infertility and 5 patients had primary amenorrhea were selected for study. Uterus, ovaries, tubes and cul de sac were inspected and findings noted. Next chromopertubation test was done with 10-15 ml of 1% aqueous methylene blue via the leech-Wilkinson cannula was inserted and findings noted and statistical Analysis was done.India showed the mean age of infertility was 28.4years. 81.16% subjects had primary whereas 16.43% had secondary infertility.In the present study maximum 165 (79.7%) had normal size uterus. Out of which 8 (3.86%) had bicornuate uterus.6.28% subjects had large size uterus. Out of which 5.80% had fibroid and 0.48% had adenomyosis.Diagnostic Laparoscopy and hysteroscopy is a better modality for diagnosing uterine, tubal and ovarian causes of infertility compared to hysterosalpingography and ultrasonography. Most of the patients had normal ultrasonographic, hysterosalpingographic and laparoscopic findings. Out of the rest, Structural adhesions were the most common cause of infertility among women in reproductive group.
Outfacing second wave of pandemic in COVID-19 positive mothers at Gandhi hospital
Authors: Sharif Amreen , Janaki Vellanki 
Published: November 2021

The novel coronavirus is a single stranded RNA virus with spike proteins triggering an immune response leading to cytokine storm and coagulopathy. Pregnancy is an immunocompromised and hypercoagulable state, with predisposition to severe illness. An insight into impact of COVID-19 in pregnancy is essential to combat its future.This study was conducted at a tertiary care centre. Analytical study was conducted from the data collected regarding COVID-19 positive labour room admissions, deliveries and deaths during the second wave of pandemic.There was a discharge rate of 88.14% after safe delivery. Among COVID-19 maternal mortalities, most deaths were due to ARDS. Quick SOFA score was a good predictor for morbidity and mortality. Deranged coagulation profile and D-Dimer levels more than 500 ng/ml were good predictors of mortality. Silent hypoxia needs to be identified and corrected at admission. Delay in seeking medical advice was a major contributory risk factor.Increasingawareness among public about seeking medical advice during early stages of disease. Early identification and treatment according to latest guidelines for a positive outcome.Making aware the policy makers regarding risk-benefits of vaccination in mothers can come a long way in changing the fate of COVID-19 in pregnancy.