bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telemedizin in der rehabilitativen Nachsorge von Frauen mit
Brustkrebs – Eine systematische Übersicht
Authors: Tokgöz Pinar , Dockweiler Christoph 
Published: August 2021

Zusammenfassung
Hintergrund Brustkrebs ist die bedeutendste Krebserkrankung bei Frauen. Die
tumor- und therapiebedingten Folgen führen zu einer langfristigen
Beeinträchtigung der Funktionsfähigkeit. Der nachhaltige
Transfer rehabilitativer Erfolge in den Alltag stellt eine Herausforderung
für alle Akteure des Systems dar. Der Einsatz von Telemedizin erscheint
vor diesem Hintergrund als eine Möglichkeit, das in der Rehabilitation
Erreichte im Alltag langfristig zu stabilisieren. Das Ziel der vorliegenden
Übersicht ist es die Evidenz von telemedizinischen Nachsorgeangeboten
bei Frauen mit Brustkrebs darzulegen und die Wirksamkeit auf verschiedenen
Ebenen der Funktionsfähigkeit herauszuarbeiten.
Methodik Es erfolgte eine systematische Suche nach deutsch- oder
englischsprachigen randomisiert kontrollierten Studien zur Wirksamkeit von
telemedizinischen rehabilitativen Nachsorgeangeboten für Frauen mit
Brustkrebs in den Fachdatenbanken PubMed und The Cochrane Library im Zeitraum
April bis Mai 2020 und einer Aktualisierung der Suche im August 2020.
Ergebnisse Insgesamt wurden 11 relevante Publikationen zu 10
Interventionsstudien identifiziert. Es wurde keine Studie aus Deutschland
gefunden. Es fanden sich Studien für die Bereiche psychosoziale
Interventionen und Interventionen zur Lebensstilveränderung.
Hinsichtlich der untersuchten Zielvariablen sind vor dem Hintergrund der
heterogenen Studienlage in einzelnen Parametern (therapieinduzierte
Wechseljahresbeschwerden, Fatigue, Schlaffunktionen, Adhärenz) Hinweise
auf positive Effekte zugunsten der Intervention festzustellen. Für einen
Teil der Parameter (mentale Funktionen bzw. emotionale und kognitive Funktionen,
gesundheitsbezogene Lebensqualität) kann jedoch keine ausreichende und
belastbare Evidenz zur Wirksamkeit konstatiert werden.
Schussfolgerungen Die Ergebnisse betonen den Bedarf der stärkeren
Evidenzbasierung von telemedizinischen Angeboten zur rehabilitativen Nachsorge
der Frauen mit Brustkrebs. Zur Absicherung der Befundlage sind randomisiert
kontrollierte Studien im deutschen Versorgungskontext erforderlich.
Impact of restrictions due to COVID-19 on a quality-assured screening colonoscopy program
Authors: Hinterberger Anna , Jiricka Lena , Waldmann Elisabeth A. , Penz Daniela , Majcher Barbara , Asaturi Arno , Szymanska Aleksandra , Rockenbauer Lisa , Ferlitsch Arnulf , Trauner Michael H. , Ferlitsch Monika 
Published: August 2021

Abstract
Background and study aims On February 25, 2020, the first patient was diagnosed with COVID-19 in Austria. On March 16, 2020, the Austrian government imposed restrictions and subsequently the Austrian Medical Association recommended minimizing screening examinations in compliance with government restrictions. The aims of this study were to evaluate the impact of this recommendation on the number of colonoscopies performed weekly and detection of non-advanced adenomas, advanced adenomas (AA) and colorectal cancer (CRC) and to calculate how many undetected adenomas could have developed into CRC.
Methods We analyzed the number of colonoscopies and pathological findings within a quality assured national colorectal cancer screening program before the COVID-19 pandemic (March 1,t 2019 to September 1, 2019, Period 1) and compared those rates to months during which access to colonoscopy was limited (March 1, 2020 and September 1, 2020, Period 2) with a Wilcoxon-rank-test and a chi-square test.
Results A total of 29,199 screening colonoscopies were performed during Period 1 and 24,010 during Period 2. The mean rate of colonoscopies per week during Period 1 was significantly higher than during Period 2 (808,35 [SD = 163,75] versus 594,50 [SD = 282,24], P = 0.005). A total of 4,498 non-advanced adenomas were detected during Period 1 versus 3,562 during Period 2 (P < 0.001). In total 1,317 AAs and 140 CRCs were detected during Period 1 versus 919 AAs and 106 CRCs during Period 2. These rates did not differ significantly (P = 0.2 and P = 0.9).
Conclusions During the COVID-19 crisis, the number of colonoscopies performed per week was significantly lower compared to the year before, but there was no difference in the detection of CRCs and AAs.
Unified magnifying endoscopic classification for esophageal, gastric and colonic lesions: a feasibility pilot study
Authors: Inoue Haruhiro , Fujiyoshi Mary Raina Angeli , Toshimori Akiko , Fujiyoshi Yusuke , Shimamura Yuto , Tanabe Mayo , Nishikawa Yohei , Mochizuki Yuichiro , Sakaguchi Takuki , Kimura Ryusuke , Izawa Shinya , Ikeda Haruo , Onimaru Manabu , Uragami Naoyuki 
Published: August 2021

Abstract
Background and study aims Image-enhanced magnifying endoscopy allows optimization of the detection and diagnosis of lesions found in the gastrointestinal tract. Current organ-specific classifications are well-accepted by specialized endoscopists but may pose confusion for general gastroenterologists. To address this, our group proposed the Unified Magnifying Endoscopic Classification (UMEC) which can be applied either in esophagus, stomach, or colon. The aim of this study was to evaluate the diagnostic performance and clinical applicability of UMEC.
Patients and methods A single-center, feasibility pilot study was conducted. Two endoscopists with experience in magnifying narrow band imaging (NBI), blinded to white-light and non-magnifying NBI findings as well as histopathological diagnosis, independently reviewed and diagnosed all images based on UMEC. In brief, UMEC is divided into three categories: non-neoplasia, intramucosal neoplasia, and deep submucosal invasive cancer. The diagnostic performance of UMEC was assessed while using the gold standard histopathology as a reference.
Results A total of 303 gastrointestinal lesions (88 esophageal squamous lesions, 90 gastric lesions, 125 colonic lesions) were assessed. The overall accuracy for both endoscopists in the diagnosis of esophageal squamous cell cancer, gastric cancer, and colorectal cancer were 84.7 %, 89.5 %, and 83.2 %, respectively. The interobserver agreement for each organ, Kappa statistics of 0.51, 0.73, and 0.63, was good.
Conclusions UMEC appears to be a simple and practically acceptable classification, particularly to general gastroenterologists, due to its good diagnostic accuracy, and deserves further evaluation in future studies.
Bowel preparation with 1L polyethylene glycol and ascorbate NER1006 doubles the chance to detect three or more adenomas in overweight or obese males
Authors: Epstein Michael , Halonen Juha , Sharma Prateek 
Published: August 2021

Abstract
Background and study aims Men have more colon cleansing failures, colorectal adenomas, and colorectal cancers than women. We analyzed whether 1-liter (1 L) polyethylene glycol (PEG) NER1006 improves high-quality (HQ) colon cleansing and adenoma detection in males versus two mid-volume alternatives.
Patients and methods The analysis of 1028 adult patients in two randomized clinical trials was performed. Adenoma detection and HQ cleansing were compared for overnight split dosing regimens with NER1006 (n = 513) versus combined oral sulfate solution or 2 L PEG + ascorbate (OSS/2 L PEG) (n = 515). Analyses included males versus females, overweight or obese (OO) males versus lean males, and NER1006 versus OSS/2 L PEG. In male patients, the adenoma detection rate of at least 3 (ADR3 +) was predicted with multiple logistic regression and statistical comparisons used the two-sided t-test.
Results ADR3 + was greater in males versus females (10.7 % [56/524] versus 5.8 % [29/504]; P = 0.004) despite comparable adequate cleansing success rates (93.2 % [479/514] versus 93.0 % [466/501]; P = 0.912) and more HQ-scores in females (41.6 % [1069/2570] versus 45.3 % [1134/2505]; P = 0.008). ADR was almost twice as high in OO versus lean males (43.4 % [184/424] versus 23.1 % [21/91]; P < 0.001). Multivariate logistic regression predicted ADR3 + detection to be twice as likely in OO males using NER1006 versus OSS/2 L PEG (odds ratio (95 % confidence interval [CI]) = 2.049 (1.082–3.973); P = 0.030) and 90 % more likely in all males (1.902 (1.045–3.526); P = 0.037). In males, including OO males, NER1006 attained more HQ-scores per trial than OSS or 2 L PEG (P ≤ 0.017 for all comparisons).
Conclusions NER1006 predicted the detection of more males for frequent surveillance than OSS/2 L PEG.
Atrial Fibrillation Detected by Single Time-Point Handheld Electrocardiogram Screening and the Risk of Ischemic Stroke
Authors: Sun Wen , Freedman Ben , Martinez Carlos , Wallenhorst Christopher , Yan Bryan P. 
Published: August 2021

Abstract
Objective We evaluated stroke risk in patients with single time-point screen-detected atrial fibrillation (AF) and the effect of oral anticoagulants (OACs).
Methods Consecutive patients aged ≥65 years attending medical outpatient clinics were prospectively enrolled for AF screening using handheld single-lead electrocardiogram (ECG; AliveCor) from December 2014 to December 2017 (NCT02409654). Repeated screening was performed in patients with >1 visit during this period. Three cohorts were formed: screen-detected AF, clinically diagnosed AF, and no AF. Ischemic stroke risk was estimated using adjusted subdistribution hazard ratios (aSHRs) from multivariate regression and no AF as reference, and stratified according to OAC use.
Results Of 11,972 subjects enrolled, 2,238 (18.7%) had clinically diagnosed AF at study enrollment. The yield of screen-detected AF on initial screening was 2.3% (n = 223/9,734). AF was clinically diagnosed during follow-up in 2.3% (n = 216/9,440) and during subsequent screening in 71 initially screen-negative patients. Compared with no AF, patients with screen-detected AF without OAC treatment had the highest stroke risk (aSHR: 2.63; 95% confidence interval: 1.46–4.72), while aSHR for clinically diagnosed AF without OAC use was 2.01 (1.54–2.62). Among screen-detected AF, the risk of stroke was significantly less with OAC (no strokes in 196 person-years) compared with those not given OAC (12 strokes in 429 person-years), p = 0.01.
Conclusion The prognosis of single time-point ECG screen-detected AF is not benign. The risk of stroke is high enough to warrant OAC use, and reduced by OAC.
Comparison between Vinorelbine–Carboplatin and Vinorelbine–Cisplatin in Stage III–IV EGFR Mutations-Negative NSCLC
Authors: Wulandari Laksmi , Soegiarto Gatot , Febriani Anna , Fatmawati Farah , Amran Wirya Sastra 
Published: August 2021

Introduction There are a substantial number of lung cancer patients with negative mutations in Indonesia. This type of cancer is deemed to be the major contributor of lung cancer patient’s death. However, reseaerch related to therapy using vinorelbine combined with platinum-based compounds is still scarce in Indonesia. The aim of this study was to compare the efficacy and tolerability between vinorelbine and carboplatin with vinorelbin and cisplatin in stage III-IV epidermal growth factor receptor (EGFR) mutations-negative non-small cell lung cancer (NSCLC).
Methods The participants were divided into two groups—group I(vinorelbine–carboplatin) and group II (vinorelbine–cisplatin). The participants were assessed based on several measurement criteria. Not only Eq-5D was performed, but the body weight and response evaluation criteria for solid tumors (RECIST) were also examined. The participants received chemotherapy for four cycles (1 cycle = 21 days).
Results The quality of life was considered stable in 60% of group I and 60% of group II (p = 0.255). In both groups, 46.67% of participants had an increased body weight, while the other 20.00% was stable (p = 1.000). In terms of RECIST evaluation after the second cycle, 80.00% of group I and 86.67% of group II were considered to have a stable disease, with 20% of group I and none of group II had partial response (p = 0.027). However, after the fourth cycle, there were no significant difference between the groups (p = 0.734).
Conclusion In EGFR mutation-negative NSCLC patients, the combination of vinorelbine and carboplatin showed comparable outcomes to vinorelbine and cisplatin chemotherapy with no significant differences.
Parent Preferences for Neonatal Intensive Care Unit Physician Attire: A Cross-Sectional Study
Authors: Cham Parul , Laventhal Naomi , Burrows Heather , Chopra Vineet , Weiner Gary M. 
Published: August 2021

Objective Physician attire may influence the parent-provider relationship. Previous studies in adult and outpatient pediatrics showed that formal attire with a white coat was preferred. We aimed to describe parent preferences for physician attire in the neonatal intensive care unit (NICU).
Study Design We surveyed 101 parents in a level IV NICU. The survey included photographs of a physician in seven different attires. Attire was scored in five domains and parents selected the most preferred attire in different contexts. All attires were compared with formal attire with white coat. Descriptive statistics, Fisher's exact tests, and one-way analysis of variance were used to compare parent responses.
Results Scrubs without white coat (40.8 [7.0]) and formal attire without white coat (39.7 [8.0]) had the highest mean (standard deviation) composite preference scores. However, no significant differences between formal attire with white coat (37.1 [9.0]) versus any other attire were observed. When asked to choose a single most preferred attire, scrubs with a coat (32%) and formal with a coat (32%) were chosen most often, but preferences varied by clinical context and parent age. For example, parents preferred surgical scrubs for physicians performing procedures. Parents indicated that physician attire is important to them but does not influence their satisfaction with care.
Conclusion Although parents generally favored formal attire and scrubs, the variations based on the context of care and lack of significant preference of one attire suggests that a single dress code policy for physicians in a NICU is unlikely to improve the patient-provider relationship.
Key Points
Is Robotic TKA Having Added Advantage over Conventional TKA? A Comparative Study of Functional and Radiological Outcome of Robotic versus Conventional Total Knee Arthroplasty
Authors: Panchal Himanshu , Patel Ashwini S. 
Published: August 2021

Abstract
Objective Total knee arthroplasty (TKA) is most commonly performed procedure in patients who are not showing improvement in pain, activities of daily living, and quality of life by conservative modalities. Precise component implantation and soft tissue management is required to achieve desired outcome following TKA. 1.3% patients remain disappointed due to persistent pain, 24% due to instability, and 2.5% due to malalignment following TKA. Robotic TKA is associated with the use of customized implants and bone cuts leading to precise component implantation and reduced deviation from mechanical axis in coronal, transverse, and sagittal plane and proper soft tissue management. This study compares conventional against robotic TKA in terms of clinical, functional, and radiological outcome.
Materials and Methods This is a prospective randomized control trial carried over period of 3 years where patients were selected on the basis of inclusion and exclusion criteria and were randomly divided into both groups and compared using their pre- and postoperative radiological and functional outcomes as well as intraoperative and postoperative complications and statistical significance of difference was calculated.
Results There was no significant difference in terms of ROM, KOOS (Knee Injury and Osteoarthritis Outcome Score), (Knee Society Score) KSS, Eq. 5D, (Western Ontario and McMaster Universities Osteoarthritis Index) WOMAC, and (visual analog scale) VAS scores while we found significant difference in mechanical axis deviation, femoral and tibial implant alignment in both planes.
Discussion Advantages of using robotic TKA are customized preoperative planning, implants, cuts, accuracy of the intraoperative procedure, and radiological superiority with no significant differences in clinical and functional outcomes. In fact, robotic TKA is associated with steep learning curve, increased cost, and operative time. Still there are no added complications caused by it.
Molecular systematics of
Authors: Núñez-Flores Mónica , Gomez-Uchida Daniel , López-González Pablo J. 
Published: August 2021

Thouarella Gray, 1870, is one of the most speciose genera among gorgonians of the family Primnoidae (Cnidaria : Octocorallia : Anthozoa), being remarkably diverse in the Antarctic and sub-Antarctic seafloor. However, their diversity in the Southern Ocean is likely underestimated. Phylogenetic analyses of mitochondrial and nuclear DNA markers were integrated with species delimitation approaches as well as morphological colonial and polyps features and skeletal SEM examinations to describe and illustrate three new species within Thouarella, from the Weddell Sea, Southern Ocean: T. amundseni sp. nov., T. dolichoespinosa sp. nov. and T. pseudoislai sp. nov. Our species delimitation results suggest, for the first time, the potential presence of Antarctic and sub-Antarctic cryptic species of primnoids, based on the likely presence of sibling species within T. undulata and T. crenelata. With the three new species here described, the global diversity of Thouarella has increased to 41 species, 15 of which are endemic to the Antarctic and sub-Antarctic waters. Consequently, our results provide new steps for uncovering the shelf benthonic macrofauna’s hidden diversity in the Southern Ocean. Finally, we recommend using an integrative taxonomic framework in this group of organisms and species delimitation approaches because the distinctions between some Thouarella species based only on a superficial examination of their macro- and micromorphological features is, in many cases, limited.
“How was your day?”
Authors: Kim Younhee , Carlin Andrew P. 
Published: August 2021

Abstract
Based on longitudinal conversation data between a father and child collected over the period of eighteen months,
this study examines “today narrative” where the father asks the child “how was your day” when they meet after being apart during
the day. The routine provides a recurrent sequential structure, which is both located within and itself occasions further talk.
Examining the talk between this father and child longitudinally reveals how the initial sequential structure, where the child
lists activities in short run-on sentences, goes through transformation and elaboration. Indices for development include the
emergence of three-part structure in the child’s list construction, more details incorporated in the list, story prefaces, and the
emergence of assessment response (or personal voice). The overall sequential organization of the routine moves from heavy reliance
on the father’s questions to more volunteered talk by the child. This paper considers the generalizability of longitudinal
conversation analytic data.
Fabrication of defective graphene oxide for efficient hydrogen production and enhanced 4-nitro-phenol reduction
Authors: Raza Waseem , Ahmad Khursheed , Kim Haekyoung 
Published: August 2021

Abstract
Hydrogen has been considered as one of the most promising alternative energy source to solve the future energy demands due to its high energy capacity and emission-free character. The generation of hydrogen from non-fossil sources is necessary for the sustainable development of human life on this planet. The hydrolysis of sodium borohydride can quickly produce a large amount of hydrogen in situ and on-demand in the presence of the catalyst, which can be used as an alternative energy source. So, it is crucial to fabricate the highly efficient, robust, and economical catalyst for the production of hydrogen via hydrolysis of sodium borohydride. Herein, a facile and efficient approach for the synthesis of metal-functionalized reduced graphene oxide for the production of hydrogen at room temperature was used. Moreover, the synthesized catalyst has also been tested in the field of environmental catalysis for the reduction of toxic 4-nitrophenol to valuable 4-aminophenol in the presence of sodium borohydride. The enhanced activity of prepared metal-functionalized reduced graphene oxide is ascribed to a strong affinity between Fe–N
X
and reduced graphene oxide which facilitates electron transfer as well as synergistic effect. Overall, this work presents a crucial procedure for green chemistry reactions when a carbonaceous material is selected as a catalyst.
The mean-field Bose glass in quasicrystalline systems
Authors: Johnstone Dean , Öhberg Patrik , Duncan Callum W 
Published: August 2021

Abstract
We confirm the presence of a mean-field Bose glass (BG) in 2D quasicrystalline Bose–Hubbard models. We focus on two models where the aperiodic component is present in different parts of the problem. First, we consider a 2D generalisation of the Aubry–André (AA) model, where the lattice geometry is that of a square with a quasiperiodic onsite potential. Second, we consider the randomly disordered vertex model, which takes aperiodic tilings with non-crystalline rotational symmetries, and forms lattices from the vertices and lengths of the tiles. For the disordered vertex models, the mean-field BG forms across large ranges of the chemical potential, and we observe no significant differences from the case of a square lattice with uniform random disorder. Small variations in the critical points in the presence of random disorder between quasicrystalline and crystalline lattice geometries can be accounted for by the varying coordination number and the different rotational symmetries present. In the 2D AA model, substantial differences are observed from the usual phase diagrams of crystalline disordered systems. We show that weak modulation lines can be predicted from the underlying potential and may stabilise or suppress the mean-field BG in certain regimes. This results in a lobe-like structure for the mean-field BG in the 2D AA model, which is significantly different from the case of random disorder. Together, the two quasicrystalline models studied in this work show that the mean-field BG phase is present, as expected for 2D quasiperiodic models. However, a quasicrystalline geometry is not sufficient to result in differences from crystalline realisations of the BG, whereas a quasiperiodic form of disorder can result in different physics, as we observe in the 2D AA model.
An experimental investigation of mechanical properties, forming limit curves, and bending behavior of aluminum-polymer sandwich composites
Authors: Seyed Jafari P , Hashemi R , Kazemi F , Pourmorad Kaleybar S 
Published: August 2021

Abstract
This study aimed to investigate the forming limit diagrams (FLDs), mechanical properties, and bending behavior of the three kinds of sandwich composites. The core layer in all sandwich sheets consisted of polyethylene, and just the skin layers were chosen to be AA5754 or AA3105. The results showed that the sandwich sheets are an appropriate choice to be used instead of the monometallic sheets. According to the 3-point bending test results, the flexural strength of the AL 3105/Polyethylene/AL 3105 sandwich composite is about 30 percent less than the AA3105 monometallic layer. Also, the formability of the metallic sandwich composites with non-identical skin layers was studied. The results demonstrated that using one layer AA 3105 and one layer AA5754 instead of AA5754 for both skin layers, although formability decreased about 11% in the plane strain region, the cost of fabricating the composite was decreased sheet reduces almost 75%. As a result, using skin layers with the different grades of aluminum is an appropriate way to reduce the cost of fabricating the aluminum-polymer sandwich composites, in which the formability does not decrease significantly.