bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infralimbic BDNF signaling is necessary for the beneficial effects of extinction on set shifting in stressed rats
Authors: Paredes Denisse , Knippenberg Anna R. , Morilak David A. 
Published: September 2021

AbstractCurrent pharmacotherapies for posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are ineffective for many patients, and often do not restore cognitive dysfunction associated with these disorders. Behavioral therapies, such as exposure therapy, can be effective for treatment-resistant patients. The mechanisms underlying exposure therapy are not well-understood. Fear extinction as an intervention after chronic stress can model the beneficial effects of exposure therapy in rats. Extinction requires neuronal activity and protein synthesis in the infralimbic (IL) cortex for its beneficial effects. We hypothesized that extinction requires Brain-Derived Neurotrophic Factor (BDNF) activity in the IL cortex to reverse stress-induced cognitive flexibility impairments. Extinction learning reversed set-shifting deficits induced by Chronic Unpredictable Stress (CUS), tested 24 h after extinction. Blocking BDNF signaling in the IL cortex during extinction by local administration of a neutralizing antibody prevented the beneficial effects of extinction on set shifting after stress. Extinction induced activation of the BDNF TrkB receptor, and signaling pathways associated with BDNF (Akt and Erk). Administration of exogenous BDNF into IL cortex in the absence of extinction was sufficient to reverse the effects of stress on set shifting. The effects of extinction were prevented by blocking either Erk or Akt signaling in the IL cortex, whereas the effects of exogenous BDNF were dependent on Erk, but not Akt, signaling. Our observations suggest that BDNF-Erk signaling induced by extinction underlies plastic changes that can reverse or counteract the effects of chronic stress in the IL cortex.
Trajectories of alcohol consumption during life and the risk of developing breast cancer
Authors: Donat-Vargas Carolina , Guerrero-Zotano Ángel , Casas Ana , Baena-Cañada José Manuel , Lope Virginia , Antolín Silvia , Garcia-Saénz José Ángel , Bermejo Begoña , Muñoz Montserrat , Ramos Manuel , de Juan Ana , Jara Sánchez Carlos , Sánchez-Rovira Pedro , Antón Antonio , Brunet Joan , Gavilá Joaquín , Salvador Javier , Arriola Arellano Esperanza , Bezares Susana , Fernández de Larrea-Baz Nerea , Pérez-Gómez Beatriz , Martín Miguel , Pollán Marina 
Published: September 2021

Abstract
Background
Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive.

Objective
To compare the influence of distinctive trajectories of alcohol consumption throughout a woman’s life on development of breast cancer (BC).

Methods
1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women’s lifetime.

Results
Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (≥15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, ≥15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood.

Conclusions
The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.
Evaluation of ventricular systolic function by speckle tracking technique in patients with biliary atresia before and after liver transplantation
Authors: Brito Márcio Miranda , Miyatani Helena Thie , de Alencar Pereira Paulo Renato , Tannuri Ana Cristina Aoun , Tannuri Uenis 
Published: September 2021

AbstractTo evaluate the ventricular function of patients with biliary atresia (BA) before and after liver transplantation using two-dimensional speckle tracking. Observational, analytical study with healthy control group, volunteers. We recruited patients from 0 to 18 years old who were candidates for liver transplantation and patients after six months of liver transplantation performed for BA from January 1997 to August 2015 at Children’s Institute of São Paulo University Medical School. The patients were submitted to a complete conventional echocardiographic study. After that, the images were captured for global longitudinal strain (GLS). A blood sample was collected for brain natriuretic peptide (BNP) level. Ejection fraction obtained by Simpson’s method was significantly higher in the hepatic pre-transplantation group (p < 0.001), as well as left atrial size (p < 0.001) and left ventricle size (p = 0.039). The left ventricular mass index was significantly higher in pre-transplantation group (p < 0.001). The left atrium volume (p = 0.008) and the left ventricular mass index (p t = 0.035) were higher in the post-transplant group. It was observed that the lower the BNP, the lower/more negative the GLS in the post-transplant group (p = 0.038 and r = 0.427). Significant reduction in the overall longitudinal strain of the left ventricle was detected before (p = 0.01) and after liver transplantation (p = 0.019). A subclinical left ventricular systolic dysfunction was evidenced by two-dimensional speckle tracking technique before and after liver transplantation, even when compared to normal values of the last pediatric meta-analysis.
Screening of tarragon accessions based on physiological and phytochemical responses under water deficit
Authors: Mumivand Hasan , Ebrahimi Amin , Shayganfar Alireza , Khoshro Hamid Hassaneian 
Published: September 2021

AbstractIn this study, screening of Artemisia dracunculus accessions was investigated under water deficit based on physiological and phytochemical traits. The results clearly indicated that water deficit significantly reduced the relative water content, chlorophyll, and carotenoid contents and increased malondialdehyde, electrolyte leakage, and antioxidant activities. The responses of tarragon accessions to water deficit, however, were inconsistent. The HPLC analysis revealed the presence of chlorogenic, syringic, ferulic, vanillic, chicoric, and p-coumaric acids as major phenolic acids, while quercetin and herniarin were detected as the predominant flavonoid and coumarin compounds in the extracts. Our findings revealed that the water deficit not only increased the amounts of herniarin, luteolin, apigenin, caffeic acid, and syringic acid, but also introduced quercetin that was not present under normal conditions in Estahbanat. Nevertheless, these results were highly impacted by the accession type. The results indicated that Hamadan, Varamin and Estahbanat accessions could be introduced as tolerant accessions. Given the very different responses of tarragon accessions to water deficit and the diversity between these accessions, the findings of the present study could be an effective step in identifying and achieving homogeneous, drought-tolerant and high-yield potential accessions, and may help tarragon breeding programs as well as development of cultivation.
Lockdowns and their influence on Earth’s hum
Authors: Somala Surendra Nadh 
Published: September 2021

AbstractEarth’s hum at higher frequencies is disturbed substantially by human activity. Anthropogenic noise is more evident in frequencies higher than 1 Hz. The power at 10 Hz power is used from January 2020 to early May (mostly first wave of SARS-CoV-2) across various sites across the world, to show that there is a clear decrease in noise power during the lockdown period. Furthermore, this anthropogenic noise across the world during the COVID-19 lockdown period, within which vehicular movement and industrial activity have stalled in many places, is quantified into a few bins. Implications of easing the lockdown measures on the onset of second wave of pandemic are discussed.
MicroRNA-375: potential cancer suppressor and therapeutic drug
Authors: Wei Jiahui , Lu Yiran , Wang Ruiqing , Xu Xiangzhu , Liu Qing , He Song , Pan Huihao , Liu Xinmiao , Yuan Bao , Ding Yu , Zhang Jiabao 
Published: September 2021

Abstract
MiR-375 is a conserved noncoding RNA that is known to be involved in tumor cell proliferation, migration, and drug resistance. Previous studies have shown that miR-375 affects the epithelial–mesenchymal transition (EMT) of human tumor cells via some key transcription factors, such as Yes-associated protein 1 (YAP1), Specificity protein 1 (SP1) and signaling pathways (Wnt signaling pathway, nuclear factor κB (NF-κB) pathway and transforming growth factor β (TGF-β) signaling pathway) and is vital for the development of cancer. Additionally, recent studies have identified microRNA (miRNA) delivery system carriers for improved in vivo transportation of miR-375 to specific sites. Here, we discussed the role of miR-375 in different types of cancers, as well as molecular mechanisms, and analyzed the potential of miR-375 as a molecular biomarker and therapeutic target to improve the efficiency of clinical diagnosis of cancer.
Multilayer event‐based distributed control system for DC microgrids with non‐uniform delays and directional communication
Authors: Alavi Seyed Amir , Rahimian Ardavan , Mehran Kamyar , Vahidinasab Vahid 
Published: September 2021

AbstractThe secondary control layer of microgrids is often modelled as a multi‐agent distributed system, coordinated based on consensus protocols. Convergence time of consensus algorithm significantly affects transient stability of microgrids, due to changes in communication topology, switching of distributed generations (DGs), and uncertainty of intermittent energy sources. To minimise convergence time in consensus protocol, this work proposes a multilayer event‐based consensus control framework, which is resilient to communication delays and supports plug‐and‐play (P&P) addition or removal of DGs in DC microgrids of cellular energy systems. A novel bi‐layer optimisation algorithm minimises convergence time by selecting an optimal communication topology graph and then adjusts controllers' parameters. Average consensus is achieved among distributed controllers using an event‐based consensus protocol, considering non‐uniform delays between agents. A realisation method has also been introduced using the directional beamforming technique for topology assignment algorithm based on modern telecommunication technologies. Provided feasibility case study has been implemented on a real‐time hardware‐in‐the‐loop (HIL) experimental testbed, to validate the performance of the proposed framework for key purposes of voltage stabilisation and balanced power‐sharing in DC microgrids.
A privacy‐preserving approach to day‐ahead TSO‐DSO coordinated stochastic scheduling for energy and reserve
Authors: Habibi Mahdi , Vahidinasab Vahid , Sepasian Mohammad Sadegh 
Published: September 2021

AbstractProliferation of distributed energy resources (DERs) calls for a coordinated transmission and distribution (T&D) scheduling at the day‐ahead stage. The problem becomes more complicated dealing with the variability of stochastic parameters. Also, privacy and complexity are two barriers to the development of such coordinated platforms. This paper addresses these issues by introducing a hybrid centrally‐supported decentralized stochastic framework for the day‐ahead energy and reserve market with minimum complexity and the need for data‐sharing between system operators. The proposed model is able to calculate the bidirectional power exchange at the T&D interface and the separated costs, dispatches, and reserves of all market participants. The proposed model does not consider any priority for operators and increases the liquidity by facilitating participants’ access to the market platform. Also, the second‐order cone programming (SOCP) formulation is used for calculating the AC power flow of distribution grids, and the model is validated and compared with other implementation strategies. The proposed model is implemented on a modified IEEE 24‐bus test system, and results show that the model can schedule resources for supplying energy and reserves in both transmission and distribution levels in an acceptable computation time.
Change detection with cross enhancement of high‐ and low‐level change‐related features
Authors: Huang Rui , Xing Yan , Zhou Mo , Wang Ruofei 
Published: September 2021

AbstractChange detection (CD) is a fundamental yet challenging problem, which aims at detecting changed object in two observations. Recent CD methods are designed based on the off‐the‐shelf semantic segmentation network architectures, which is not optimal for extracting and using change‐related features. In this paper, a novel CD network architecture is proposed, including change‐related feature extraction, cross feature enhancement, and multi‐level supervision. Absolute difference of the features of different convolutional layers is first computed from a Unet‐like network for two observations. The features are partitioned into high‐ and low‐level features according to their functionalities. Then the high‐ and low‐level features are recurrently refined by cross feature enhancement to increase the representational ability of the features. The network learns change‐related features with multi‐level supervisions. The final CD result can be obtained by fusing multiple predictions. Experimental results on three CD benchmark datasets indicate the superiority of the authors' method when compared with six state‐of‐the‐art deep learning‐based CD methods.
Comparison of Saccular Function in Nonmusicians and Violinists Using cVEMP: A Pilot Study
Authors: D’Souza Eva Eadle , Yerraguntla Krishna 
Published: September 2021

Abstract
Introduction Human auditory and vestibular systems change due to noise exposure. Professional musicians are often subjected to loud music and longer durations as part of their practice. Although the effects of music have been explored extensively on the auditory system, it is important to understand changes in the vestibular system also. The current study is aimed to compare cervical vestibular evoked myogenic potential (cVEMP) findings in nonmusicians and violinists to understand if there are any changes in the P1 and N1 latencies and absolute amplitudes in the violinists’ groups because of their exposure to violin music.
Materials and Methods Twelve participants (6 nonmusicians and 6 violinists) of both genders were included in the study. Pure tone audiometry and distortion product otoacoustic emissions (DPOAEs) were performed on all the participants. cVEMP P1 and N1 latencies and absolute amplitudes were obtained, and overall mean differences were compared within and between groups.
Results Pure tone average and DPOAE were within the normal range between and within the groups. Results indicate that P1 and N1 absolute amplitudes and latencies were slightly prolonged in the violinists’ group; however, the mean difference was not statistically significant. Comparison of mean absolute amplitudes and latencies between the ears in the violinists’ group showed longer latencies and greater absolute amplitudes in the left ear of violinists as compared with the right ear. In the study, the violinists’ group consisted of participants who had an average daily exposure of about one-and-a-half hours and had an experience of playing the instrument for more than 5 years.
Conclusion cVEMP is useful in detecting early changes in the saccule that may occur due to noise exposure. It can be concluded that, even before a clinically detectable hearing loss or vestibular damage, changes in saccule are observed with the help of cVEMP and should be included in the audiovestibular test for early identification.
Immigration attitudes among Western and Eastern European MPs: social identity, economic aspects and political ideology
Authors: Kocijan Bojana , Kukec Marko 
Published: September 2021

AbstractThis article calls for greater attention to immigration attitudes of members of national parliaments (MPs) who absent harmonized immigration policy at the EU level remain the chief decision-makers and are thus responsible for swift government reaction to large influx of immigrants as witnessed in summer 2015 and spring 2020. Against this background, attitudes of MPs toward non-EU immigrants can be highly informative for understanding the foundation and direction of future immigration policy reforms. Although knowledge of MPs immigration attitudes is seemingly important, studies interested in this topic remain scarce. To test the relative importance of identity and economic aspects of MPs' immigration attitudes, this study adopts few well-established theoretical approaches from citizen-level research. Our data come from an MP survey that was administered in 11 Western and Eastern European countries in late 2014 as part of theEuropean National Elites and the Crisisproject. Our results suggest that social identity (religiosity) along with political ideology rather than economic concerns drive MPs' immigration attitudes. In addition, we find that in Eastern Europe immigration is only a light force behind political competition unlike in Western Europe, while economic left in Eastern Europe is more anti-immigrant than in Western Europe.
The container and force schemas in political discourse
Authors: Hampl Marek 
Published: September 2021

Abstract
The paper focuses on metaphors based on the image schemas of container and force that were employed by U.S. President Barack Obama in the campaign against ISIL (The Islamic State of Iraq and the Levant). Systematic metaphors based on the schemas of container and force illustrate the strategy of the international alliance against ISIL’s activity. The strategy included the isolation of the organization, the restriction of the flow of foreign fighters and financial resources to the area controlled by ISIL as well as planning military operations designed to weaken the influence of the organization. The analysis has been conducted on the corpus of political speeches delivered by the speaker in the period from June 2014 to September 2016. Theoretical framework that is employed in the analysis of primary data is grounded in Critical Metaphor Analysis (CMA) which explores ideological aspects of discourse.
Valorisation Wastes from Sugar Mill Plant and Water Supply Treatment Process as Alternative Materials for Ecological Ceramic Floor Tiles
Authors: Wangrakdiskul U , Poommang T 
Published: September 2021

Abstract
Wastes from many industries have an effect on environmental degradation and led problems to manufacturers for disposing them. Likewise, the sugar mill process also generates substantially wastes i.e., bagasse ash and calcium carbonate, which are difficult to eliminate. Furthermore, in water supply treatment process, it has generated the abundant of sediment soil, which are still unutilized and need budgeting for disposing. This research aims to utilize wastes from sugar mill process and water supply treatment process for developing eco-friendly floor tiles ceramics by implementing bagasse ash, calcium carbonate and sediment soil. Tri axial diagram is employed to construct the formula mixtures of three alternative materials with adding brown cullet glass. After dry mixing for all materials according to formulas mixtures, they are moulded by 100 bars of uniaxial pressing in dimension 50 × 100 × 7 mm. Then, they are fired at 1100° and 1150° C. Physical properties; bending strength, water absorption, bulk density, % shrinkage, % weight loss is examined. Bending strength and water absorption are compared with TIS 2508-2555. In addition, microstructure of fired specimens is analysed by Scanning Electron Microscope and X-ray Diffractometer.
Development of Aerotropolis in Kulon Progo with Green Infrastructure Concept
Authors: Syaifuddin Muhammad , Purnomo Eko Priyo , Salsabila Lubna , Fathani Aqil Teguh , Mitra Adrian Maisarah 
Published: September 2021

Abstract
This study aims to analyze the development of Aerotropolis in the Yogyakarta region with a development concept that prioritizes green development values. Aerotropolis is a multi-purpose development where the airport serves as a focal point and is surrounded by multi-purpose business districts and transportation systems. An airport in an area will almost certainly spur the development of the following industries: warehousing, real estate, aircraft repair shops, tourism and restaurants. This research is qualitative research using secondary data, namely: national, regional and district government documents in the form of the Basic Medium- and Long-Term Development Articles of Association and Regional Spatial Planning Plans. The results show that: the Aerotropolis development concept in Jogjakarta will have a good impact on the regional and national economy. This can be confirmed by the faster and easier movement of the economy between regions and countries. Also, the concept of Aerotropolis development in Jogja is carried out by paying attention to environmental, agricultural aspects and strengthening green infrastructure concepts.
Acoustic spin and orbital angular momentum using evanescent Bessel beams
Authors: Rondón Irving 
Published: September 2021

Abstract
The fundamental properties for the spin and orbital angular momentum are analyzed using acoustic evanescent Bessel beams. The calculations reveal that the transversal spin, the canonical momentum, and the orbital angular momentum are proportional to the ratio l/ω where l is the topological charge and ω the angular frequency. This analysis shows that the complex acoustic Poynting vector and spin density exhibits interesting features related to the electromagnetic case.