bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elizabeth Stuart, Queen of Hearts
Authors: Akkerman Nadine 
Published: December 2021

Abstract
This book presents a biography of Elizabeth Stuart, one of the most misrepresented and underestimated figures of the seventeenth century. Elizabeth Stuart, daughter of James VI and I, was married to Frederick V, Elector Palatine in 1613. The couple were crowned King and Queen of Bohemia in 1619, only to be deposed in 1620 and exiled to the Dutch Republic in 1621. Elizabeth then found herself at the epicentre of the Thirty Years War and the Civil Wars, political and military struggles that defined seventeenth-century Europe. Following her husband’s death in 1632, Elizabeth fostered a cult of widowhood and conducted a long and fierce political campaign to regain her children’s birthright. On returning to England in 1661, Elizabeth Stuart found a country whose people still considered her their ‘Queen of Hearts’. This book reveals the impact Elizabeth Stuart had on the Stuart kingdoms and Europe, demonstrating that she was more than just the grandmother of George I.
Inseverable Ties with Austria and Spain
Authors: Akkerman Nadine 
Published: December 2021

Abstract
Maximilian I, Duke of Bavaria, was afraid of Habsburg expansionism and proposed a counter offer to the Palatine-Imperial match: instead of Frederick Henry, heir of the Palatinate, marrying a daughter of the Emperor, he should marry Bavaria’s niece. The monk Francesco della Rota took this proposal straight to London instead of to The Hague. It floundered. Parliament voted in favour of war with Spain, on condition that it would be a purely naval conflict. The Dutch were keen to support such a war against their enemy, with ships sailing out under Elizabeth’s flag, if the Stuart kingdoms indeed gathered their own fleet. James’s declaration of war never came, however. Meanwhile, having convinced Louis XIII of France to subsidize his military actions in the Palatinate as long as James also sponsored him, Mansfeld went to London intent on levying troops. James agreed. The Spanish ambassador at the Stuart court was irritated by the bellicose attitude against the Spanish at court and accused Elizabeth, her secretary Sir Francis Nethersole, and court favourite Buckingham of having purposely derailed the Spanish Match in order to effect a marriage between Frederick Henry, Prince Palatine, and Buckingham’s daughter Mary. This, he suggested, was so that they would see their offspring on the throne some day. (That this scheme entailed Charles never marrying was apparently seen as within Buckingham’s power to effect, too). James took the side of his daughter (and his favourite) and dismissed all Spanish diplomats from his court.
Epilogue
Authors: Akkerman Nadine 
Published: December 2021

Abstract
This epilogue highlights Elizabeth Stuart's legacy in material, and subsequently, in immaterial terms. It considers the contents of the will that was drawn up shortly before she left The Hague for the last time. In simple terms, Charles Louis inherited her estates; Rupert received her rings, plate, and other goods; Edward received a table diamond with a ribbon; Elisabeth a pair of emerald earrings; and Sophia the small necklace of pearls Elizabeth had always worn. The jewels Rupert inherited were, if Sophia is to be believed, given by him to his mistress Margaret Hughes, the first actress to play Desdemona. The executor of Rupert’s will, Lord Craven, presumably sold the rest to settle debts (though Elizabeth’s debts were never fully settled) and to ensure Rupert’s daughter, Ruperta, was well provided for. The Crown of the Three Kingdoms eventually came to rest on the head of one of Elizabeth’s grandchildren: Sophia's son, Georg Ludwig, Elector of Hanover, was crowned King George I of Great Britain in 1714, starting a line which reaches directly down to the longest serving monarch of the United Kingdom, Queen Elizabeth II. In the sixty-five years that she lived, Elizabeth Stuart touched every corner of Europe. Indeed, her true legacy is incalculable and it is no exaggeration to say that the original Queen of Hearts is still with us.
Understanding the Lived Experience of Caring for a Child With Severe Cerebral Palsy: A Critical Step Toward Psychologically Informed Family-Centered Care
Authors: Cook Jason E , Tovin Melissa M , Kenyon Lisa K 
Published: December 2021

Abstract

Objective
The purpose of this study was to explore the lived experience of parents who care for children with cerebral palsy who function at a Gross Motor Function Classification System Level V, their beliefs about pain and non–pain-related emotional distress, and what it means to provide care and comfort.

Methods
A phenomenological research design was used. Eleven participants were involved in this study. Pilot interviews informed the interview guide. Data were collected via participant journals and semi-structured interviews and analyzed using van Manen’s framework for understanding experience. Trustworthiness criteria were met through a variety of strategies to ensure a rigorous research process.

Results
Four themes were revealed in this study: “life is hard, heavy with burden, worry, and love,” “remarkable,” “identity transformation and empowerment,” and “living a life that is planned, forced with structure and without spontaneity.”

Conclusion
Caring for a child with lifelong needs is complex and requires a sensitive awareness of the contextual factors that impact daily decisions and routines. Understanding the lived experiences of parents who care for children with cerebral palsy Gross Motor Function Classification System Level V is necessary to provide psychologically informed, family-centered care. Comfort theory is presented as a framework for understanding what factors influence comfort and well-being. Understanding the complex nature of comfort for an individual can lead to greater understanding and empathy-driven care. These results will provide a foundation for future studies that aim to enhance pediatric physical therapist care through provider empathy and understanding.

Impact
Caregiving parent experiences are impactful and play a large role in the life of children with developmental disabilities. Research exploring the lived experience of caregivers may enhance empathy-driven, psychologically informed, family-centered physical therapist care throughout the life course.

Lay Summary
If you are a parent who cares for a child with severe cerebral palsy, you have unique experiences that impact day-to-day activities and lifelong planning for your family and child.
Women with abuse-related posttraumatic stress disorder sleep more fitfully but just as long as healthy controls: an actigraphic study
Authors: Friedmann Franziska , Hill Holger , Santangelo Philip , Ebner-Priemer Ulrich , Neubauer Andreas B , Rausch Sophie , Steil Regina , Müller-Engelmann Meike , Lis Stefanie , Fydrich Thomas , Priebe Kathlen 
Published: December 2021

AbstractStudy ObjectivesSubjective reports of sleep impairments are common in individuals with posttraumatic stress disorder (PTSD), but objective assessments of sleep have yielded mixed results.MethodsWe investigated sleep via actigraphy and e-diary on 6 consecutive nights in a group of 117 women with PTSD after childhood abuse (CA; PTSD group), a group of 31 mentally healthy women with a history of CA (healthy trauma controls, HTC group) and a group of 36 nontraumatized mentally healthy women (healthy controls, HC group).ResultsThe PTSD group reported lower sleep quality, more nights with nightmares, and shorter sleep duration than both HTC and HC. Actigraphic measures showed more and longer sleep interruptions in the PTSD group compared to HTC and HC, but no difference in sleep duration. While the PTSD group underestimated their sleep duration, both HTC and HC overestimated their sleep duration. HTC did not differ from HC regarding sleep impairments.ConclusionsSleep in women with PTSD after CA seems to be more fragmented but not shorter compared to sleep patterns of mentally healthy control subjects. The results suggest a stronger effect of PTSD psychopathology on sleep compared to the effect of trauma per se.Subset of Data from Clinical TrialTreating Psychosocial and Neural Consequences of Childhood Interpersonal Violence in Adults (RELEASE), https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00000000, German Clinical Trials registration number: DRKS00005578
Molecular characterisation of carbapenem-resistantKlebsiella pneumoniaeclinical isolates: preliminary experience from a tertiary care teaching hospital in the Himalayas
Authors: Bhatia Mohit , Shamanna Varun , Nagaraj Geetha , Sravani Dharmavaram , Gupta Pratima , Omar Balram Ji , Chakraborty Deepika , Ravikumar K L 
Published: December 2021

AbstractBackgroundThere is a lack of whole-genome sequencing (WGS) data on multidrug-resistant (MDR) bacteria from the Uttarakhand region of India. The aim of this study was to generate WGS data of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates recovered from patients in Uttarakhand's tertiary care centre.MethodsA cross-sectional study included 29 MDR K. pneumoniae test isolates obtained from various clinical samples submitted to the bacteriology laboratory for culture and sensitivity testing from July 2018 to August 2019. After preliminary identification and antibiotic susceptibility testing, these isolates were subjected to WGS.ResultsA total of 27 of 29 isolates were CRKP. ST14 was the most common sequence type (n=8 [29.6%]). Carbapenem resistance was mainly encoded by OXA-48-like genes (21/27 [77.8%]). All isolates had a varied arsenal of resistance genes to different antibiotic classes. KL2 (9/27 [33.3%]) and KL51 (8/27 [29.6%]) were dominant K loci types. O1 and O2 together accounted for 88.9% (n=27) of CRKP isolates. Genes encoding yersiniabactin (ybt) and aerobactin (iuc) were identified in 88.9% (24/27) and 29.6% (8/27) of isolates. The predominant plasmid replicons present were ColKP3 (55.5%), IncFII(K) (51.8%) and IncFIB(pQil) (44.4%).ConclusionsThis study emphasises the need for continued genomic surveillance of MDR bacteria that could be instrumental in developing treatment guidelines based on integrating phenotypic and molecular methods.
Carvedilol as secondary prophylaxis for variceal bleeding in hepatosplenic schistosomiasis
Authors: de Abreu Eliabe Silva , Nardelli Mateus Jorge , Lima André Mourão Costa , Cardoso Jaqueline Brito , Osório Fernanda Maria Farage , Ferrari Teresa Cristina de Abreu , Faria Luciana Costa , Couto Cláudia Alves , Cançado Guilherme Grossi Lopes 
Published: December 2021

Abstract

Background
Upper variceal bleeding (UVB) is a possible complication of portal hypertension secondary to hepatosplenic schistosomiasis (HSS). Propranolol is a non-selective beta-blocker used as secondary prophylaxis for UVB, but no previous studies have addressed carvedilol effects in rebleeding prevention.

Methods
A retrospective exploratory study of 57 patients with chronic HSS and index UVB treated with endoscopic variceal ligation and propranolol or carvedilol was conducted. The primary outcome was UVB-free time in the first 12 mo after the initial bleeding episode.

Results
Propranolol was used for secondary UVB prophylaxis in 43 (75.4%) participants (median dose 80 [interquartile range – IQR 60–80] mg/d) and carvedilol in 14 (24.6%) participants (median dose 12.5 [IQR 7.9–25.0] mg/d). During a 12-mo follow-up, rebleeding was observed in 13 (22.8%) patients, 9 (20.9%) of those treated with propranolol and 4 (28.6%) treated with carvedilol (p=0.715). Mean time from the beginning of drug prophylaxis to rebleeding was 6±3 mo and there was no difference between that for propranolol vs carvedilol subgroups. Portal vein thrombosis did not influence the bleeding recurrence in either subgroup.

Conclusion
Carvedilol may be equally effective as propranolol in preventing secondary UVB in HSS at 12-mo follow-up.
Which injected antiosteoporotic medication is worth paying for? A cost-effectiveness analysis of teriparatide, zoledronate, ibandronate, and denosumab for postmenopausal osteoporotic women in China
Authors: You Ruxu , Mori Takahiro , Ke Lei , Wan Yuansheng , Zhang Yu , Luo Fei , Feng Da , Yu Guangyi , Liu Jinyu 
Published: December 2021

Abstract

Objective:
The purpose of this study was to evaluate the cost-effectiveness of four injected antiosteoporotic medications including teriparatide, zoledronate, ibandronate, and denosumab for postmenopausal osteoporotic women in China.

Methods:
A Markov microsimulation model was used to compare the cost-effectiveness of the four drugs above in Chinese postmenopausal osteoporotic women with no fracture history of hip, vertebral, or wrist at various ages (65, 70, 75, and 80) of therapy initiation from the health care payer perspective.

Results:
Denosumab was dominant (ie, lower costs and greater quality-adjusted life-years [QALYs]) compared with other strategies at all ages studied. The incremental cost-effectiveness ratios (ICERs) of zoledronate or ibandronate versus no treatment were $4,482.88/ QALYs or $11,378/QALYs, respectively, at age 65 years, and the results at other ages were similar. In contrast, the incremental cost-effectiveness ratio of teriparatide strategy compared with no treatment exceeded the pre-determined threshold of a willingness-to-pay of $31,512/QALY regardless of the adoption of the patient assistance program at all ages studied, and a threshold analysis showed that teriparatide without patient assistance program became cost-effective when the annual drug cost is decreased to $1,644.87 (current cost: $8,764.65). The cost-effectiveness decision did not change in most of the one-way sensitivity analyses. A scenario analysis considering no offset effect of denosumab showed that zoledronate had the potential to become the optimal option relative to denosumab. In probabilistic sensitivity analyses, the probabilities of denosumab being cost-effective compared with other strategies were 100% at a willingness-to-pay of $31,512/QALY.

Conclusions:
Among postmenopausal osteoporotic women in China, denosumab therapy is cost-effective at all ages examined from the health care payer perspective, compared with teriparatide, zoledronate, or ibandronate. This study will help clinicians and policymakers make better decisions about the relative economic value of osteoporosis treatments in China.
Impact of early glomerular filtration rate decline in response to antihypertensive treatment on risk of end-stage kidney disease and cardiovascular outcomes: a systematic review and meta-analysis
Authors: Gambaro Alessia , Lombardi Gianmarco , Ribichini Flavio L. , Mantovani Alessandro , Bignamini Angelo A. , Gambaro Giovanni 
Published: December 2021

Blood pressure control, which can induce a slight decrease in the glomerular filtration rate (GFR), plays a nephron- and cardioprotective role. However, the more important early decline in GFR associated with antihypertensive therapy and strict blood pressure targets is still of concern. Since few data are available from trials and observational studies, and the phenomenon is relatively rare, we performed a meta-analysis of available studies.
We conclude that major reductions in the glomerular filtration rate occurring soon after starting angiotensin-converting enzyme inhibitors/angiotensin receptor blockers and/or under intensive blood pressure control predict end-stage kidney disease.
A challenging case of intravascular large B-cell lymphoma presenting as pyrexia of unknown origin
Authors: Wilfred Gilbert , Shukri Hamizah , Lau Ngee Siang , Fauzi Alina Md , Tan Sen Mui , Ahmad Asnawi Asral Wirda 
Published: December 2021

Abstract

Introduction:
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of large cell lymphoma, characterized by the growth of neoplastic cells within the lumina of small blood vessels, without an obvious extravascular tumor mass or presence of circulating lymphoma cells in the peripheral blood.

Patient concern:
A 68-year-old woman presented with fever of unknown origin and abdominal pain.

Diagnosis:
Bone marrow aspiration showed abnormally large cells with increased hemophagocytic activity. Trephine biopsy showed moderate to large neoplastic cells with single and multiple prominent nucleoli sequestered in the blood vessel lumen. Immunohistochemistry was positive for CD20, PAX5, CD79a, MUM1, and BCL2 and showed a high proliferative fraction of 80% confirming the diagnosis of IVLBCL.

Interventions:
The patient received six cycles of R-CHOP chemotherapy.

Outcomes:
The patient has been in remission for nearly two years after completing the treatment.

Conclusion:
Clinical recognition of IVLBCL remains a challenge. Standard staging and therapeutic approaches need to be addressed to further elucidate the characterization and management of this rare disease.
Renal manifestations of paediatric systemic lupus erythematosus
Authors: Dowsett Thomas , Oni Louise 
Published: December 2021

Purpose of review
Systemic lupus erythematosus is a lifelong, multisystemic disease. Around a fifth of patients present during childhood. Children are recognized to have a more active disease course with more renal involvement (lupus nephritis) when compared with adults. This review article summarizes the current literature surrounding the management of paediatric lupus nephritis.

Recent findings
International recommendations agree that active, proliferative forms of lupus nephritis are treated with a period of intense induction therapy aimed at inducing remission followed by maintenance immunosuppressive therapy for at least 3 years. Complete response rates in lupus nephritis remain inadequate, in the region of 40–60%, and disease flares are common. Revised histological classification have been proposed but they are yet to be adopted in clinical practice. Lupus nephritis progresses to chronic kidney disease (CKD) stage 5 (kidney failure) in more than 10% of patients within 10 years however the rates of CKD stages 1–4 remain largely unknown. Current trials are focused on the use of biologic agents as adjuncts to current therapy.

Summary
There is an urgent need for better outcomes in paediatric lupus nephritis. The use of biomarkers to monitor lupus nephritis and scientific studies to improve our understanding of the pathogenesis offer hope of improved outcomes.
Impact of coronavirus disease on the management of lower urinary tract symptoms and voiding dysfunction
Authors: Can Osman , Otunctemur Alper 
Published: December 2021

Purpose of review
Coronavirus disease (COVID-19) has caused a crisis in the entire healthcare system since its emergence. The urgency and priority of various diseases have impacted the medical and surgical treatment in this period. We aim to review the impact of COVID-19 on lower urinary tract symptoms (LUTS) and management.

Recent findings
There may be a relationship between COVID-19 and de novo or increased LUTS. Patients with LUTS should also be evaluated for COVID-19. Management of diseases has varied during the COVID-19 due to the density of the pandemic. Virtual consultations can mitigate patients who are postponed or cancelled, such as patients with LUTS. Patients suffering voiding dysfunction may manage with oral medications such as alpha blocker and 5-alpha reductase inhibitor via telemedicine. Minimally invasive procedures with a low risk of complications and a short hospitalization time should be considered in complicated cases such as the inability to catheterize.

Summary
Telemedicine should be implemented on managements of noncomplicated LUTS and voiding dysfunction. Each centre can schedule its LUTS management approach according to the density of pandemic. Virtual consultations need to be developed to compete with face-to-face consultations.
Telehealth interventions for mobility after lower limb loss: A systematic review and meta-analysis of randomized controlled trials
Authors: Esfandiari Elham , Miller William C. , Berardi Anna , King Sheena , Ashe Maureen C. 
Published: December 2021

Background:
Mobility is a crucial component for healthy aging after lower limb loss (LLL). Telehealth technologies, for example, smart devices, are novel approaches for health programs delivery regardless of geographical boundaries.

Objectives:
To assess the effect of telehealth interventions on mobility, quality of life, and antecedents of health behavior compared with a control condition (usual care or simpler telehealth interventions with fewer number of behavior change techniques [BCTs]) for community-dwelling adults (>50 years) with an LLL and the effect of mode of delivery and BCTs used in telehealth interventions on health outcomes.

Study design:
Systematic review and meta-analysis.

Methods:
We systematically searched MEDLINE, PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, Cochrane, PsycINFO, and SPORTDiscus on January 28, 2021, to identify relevant randomized controlled trials. Two authors independently screened records and assessed risk of bias. We conducted a narrative synthesis of evidence and, when appropriate, used the standardized mean difference (SMD) and mean difference for meta-analyses and the Grading Recommendations Assessment, Development, and Evaluation approach for practice recommendations.

Results:
We identified six randomized controlled trials. Telephone was the most common delivery mode (n = 3), and “instructions for performing behaviors” was the most common BCT (n = 5). Very low certainty evidence showed no changes in mobility (six studies: SMD = 0.33 [95% confidence interval [CI] = −0.08, 0.75]), quality of life (two studies: mean difference = −0.08 [95% CI = −0.30, 0.15]), and antecedents of behavior (five studies: SMD = 0.04 [95% CI = −0.28, 0.36]).

Conclusions:
Our review highlights a knowledge gap for the effect of telehealth interventions for people with LLL. Although no promising effect was shown for telehealth interventions, very low certainty evidence precludes making a definitive clinical recommendation.
Balance control deficits in individuals with a transtibial amputation with and without visual input
Authors: Moisan Gabriel , Miramand Ludovic , Younesian Hananeh , Turcot Katia 
Published: December 2021

Background:
Many individuals with a transtibial amputation (TTA) exhibit balance deficits after limb loss. However, limited evidence exists on balance deficits of individuals with a TTA using hip, knee, and ankle kinematics and center of mass outcomes.

Objectives:
To identify balance control deficits in individuals with a TTA and determine to what extent they are accentuated without visual inputs.

Study design:
Cross-sectional.

Methods:
Ten individuals with TTA and 10 healthy controls undertook a biomechanical assessment during a 30-s quiet standing task with eyes open (EO) and eyes closed (EC). The mean trunk, hip, knee, and ankle angles and center of pressure (COP) and center of mass excursions were calculated.

Results:
More ankle dorsiflexion was observed for amputated limbs compared with intact lower limbs (mean difference: 5.8-degree, P = 0.031). Less anteroposterior (mean difference: 26.5 mm, P < 0.001) and mediolateral (ML) (mean difference: 4.2 mm, P = 0.042) COP excursions were found for amputated limbs compared with intact lower limbs and for control limbs compared with intact limbs (mean difference: 18.8 mm, P = 0.019). Greater ML COP excursion was found during EC than during EO condition (mean difference: 1.1 mm, P = 0.037).

Conclusions:
Individuals with a TTA presented a greater reliance on the intact lower limb, as highlighted by the greater ankle plantarflexion and anteroposterior and ML COP excursions for intact limbs compared with amputated limbs during quiet standing tasks. During EC condition, both groups exhibited greater ML COP excursions compared with EO condition, suggesting less postural stability. These differences may place them at greater risk of falling.