bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subcutaneous immunoglobulin in allogeneic hematopoietic cell transplant patients
Authors: Pasic Ivan , Alanazi Wael , Dranitsaris George , Lieberman Lani , Viswabandya Auro , Kim Dennis Dong Hwan , Lipton Jeffrey H. , Michelis Fotios V. 
Published: February 2021

Background:
We evaluated feasibility, safety, and total resource use of subcutaneous immunoglobulin (SCIG) in a pilot study of patients who underwent allogeneic hematopoietic cell transplant (HCT) over a 6-month period.

Methods:
A total of 20 eligible patients were treated with SCIG at 0.1 g/kg/week for up to 6 months. Patients were matched to 20 concurrent intravenous immunoglobulin (IVIG) controls. Clinical outcomes measured included adverse reactions, healthcare resource use, patient satisfaction, and quality of life (QOL). (ClinicalTrials.gov Identifier: NCT03401268).

Results:
Groups were comparable in terms of age, weight, sex, transplant indication, donor type, and conditioning intensity. All 20 IVIG patients completed 6 consecutive months of therapy compared with 13/20 (65%) SCIG patients. There were no adverse reactions in IVIG patients, compared with six (30%) SCIG patients. All adverse reactions in SCIG patients were grade I, transient, and required no medical intervention. Median overall cost per patient was lower with SCIG than with IVIG ($9,756 vs. $13,780, p = .046). Among patients who completed 6 months of SCIG, median preference and satisfaction scores were 100%. Over the 6-month period, QOL scores remained stable in SCIG patients.

Conclusions:
In a subgroup of patients, SCIG was associated with high patient satisfaction and a reduction in total healthcare costs compared with IVIG in a cohort of HCT patients.
Does Preoperative Calcium and Calcitriol Decrease Rates of Post-Thyroidectomy Hypocalcemia? A Randomized Clinical Trial
Authors: Donahue Colleen , Pantel Haddon J. , Yarlagadda Bharat B. , Brams David 
Published: February 2021

BACKGROUND:
Postoperative hypocalcemia is the most common complication after thyroidectomy. Postoperative supplementation with calcium and calcitriol reduces its occurrence; however, prophylactic preoperative supplementation has not been studied systematically. The primary objective of this study was to determine whether pre- and postoperative calcium and calcitriol supplementation reduces postoperative hypocalcemia after total thyroidectomy compared with postoperative supplementation alone.

STUDY DESIGN:
We conducted a single-institution prospective randomized trial enrolling 82 patients undergoing total thyroidectomy from July 2017 through May 2019. Those undergoing partial thyroidectomy or concurrent planned parathyroidectomy were excluded. The intervention group started calcitriol 0.25 μg po bid and calcium carbonate 1,500 mg po tid 5 days preoperatively and continued postoperatively. The control group started these medications postoperatively. The primary end point was clinical or biochemical hypocalcemia. Secondary outcomes were postoperative calcium levels, need for intervention, length of stay, and readmission.

RESULTS:
Thirty-eight patients were randomized to the intervention group and 44 to the control group. There were 12 episodes of hypocalcemia; 5 (13.2%) in the intervention and 7 (15.9%) in the control group (p = 0.76). No differences were found in secondary outcomes; including postoperative calcium levels at each measured time point, need for intervention (n = 10 [26.3%], n = 15 [34.1%]; p = 0.48), length of stay (mean [SD] 32.3 [15.6] hours, 30.7 [10.5] hours; p = 0.6), or readmissions (n = 0 [0.0%], n = 3 [6.8%]; p = 0.24).

CONCLUSIONS:
Starting supplementation with calcium and calcitriol preoperatively does not reduce postoperative hypocalcemia compared with postoperative supplementation alone after total thyroidectomy. These findings do not support the practice of routine calcium and calcitriol supplementation before total thyroidectomy.
Continuous Maps from Spheres Converging to Boundaries of Convex Hulls
Authors: Malkoun Joseph , Olver Peter J. 
Published: February 2021

Abstract
Given n distinct points

$\mathbf {x}_1, \ldots , \mathbf {x}_n$

in

$\mathbb {R}^d$

, let K denote their convex hull, which we assume to be d-dimensional, and

$B = \partial K $

its

$(d-1)$

-dimensional boundary. We construct an explicit, easily computable one-parameter family of continuous maps

$\mathbf {f}_{\varepsilon } \colon \mathbb {S}^{d-1} \to K$

which, for

$\varepsilon> 0$

, are defined on the

$(d-1)$

-dimensional sphere, and whose images

$\mathbf {f}_{\varepsilon }({\mathbb {S}^{d-1}})$

are codimension

$1$

submanifolds contained in the interior of K. Moreover, as the parameter

$\varepsilon $

goes to

$0^+$

, the images

$\mathbf {f}_{\varepsilon } ({\mathbb {S}^{d-1}})$

converge, as sets, to the boundary B of the convex hull. We prove this theorem using techniques from convex geometry of (spherical) polytopes and set-valued homology. We further establish an interesting relationship with the Gauss map of the polytope B, appropriately defined. Several computer plots illustrating these results are included.
Development of a fully automated surgical site infection detection algorithm for use in cardiac and orthopedic surgery research
Authors: Suzuki Hiroyuki , Clore Gosia S. , Perencevich Eli N. , Hockett-Sherlock Stacey M. , Goto Michihiko , Nair Rajeshwari , Branch-Elliman Westyn , Richardson Kelly K. , Gupta Kalpana , Beck Brice F. , Alexander Bruce , Balkenende Erin C. , Schweizer Marin L. 
Published: February 2021

AbstractObjective:To develop a fully automated algorithm using data from the Veterans’ Affairs (VA) electrical medical record (EMR) to identify deep-incisional surgical site infections (SSIs) after cardiac surgeries and total joint arthroplasties (TJAs) to be used for research studies.Design:Retrospective cohort study.Setting:This study was conducted in 11 VA hospitals.Participants:Patients who underwent coronary artery bypass grafting or valve replacement between January 1, 2010, and March 31, 2018 (cardiac cohort) and patients who underwent total hip arthroplasty or total knee arthroplasty between January 1, 2007, and March 31, 2018 (TJA cohort).Methods:Relevant clinical information and administrative code data were extracted from the EMR. The outcomes of interest were mediastinitis, endocarditis, or deep-incisional or organ-space SSI within 30 days after surgery. Multiple logistic regression analysis with a repeated regular bootstrap procedure was used to select variables and to assign points in the models. Sensitivities, specificities, positive predictive values (PPVs) and negative predictive values were calculated with comparison to outcomes collected by the Veterans’ Affairs Surgical Quality Improvement Program (VASQIP).Results:Overall, 49 (0.5%) of the 13,341 cardiac surgeries were classified as mediastinitis or endocarditis, and 83 (0.6%) of the 12,992 TJAs were classified as deep-incisional or organ-space SSIs. With at least 60% sensitivity, the PPVs of the SSI detection algorithms after cardiac surgeries and TJAs were 52.5% and 62.0%, respectively.Conclusions:Considering the low prevalence rate of SSIs, our algorithms were successful in identifying a majority of patients with a true SSI while simultaneously reducing false-positive cases. As a next step, validation of these algorithms in different hospital systems with EMR will be needed.
Individual differences and emotional labor: the effects of core self-evaluations on depersonalization
Authors: Pujol-Cols Lucas , Dabos Guillermo E. , Lazzaro-Salazar Mariana 
Published: February 2021

AbstractThis paper examines the role of core self-evaluations (CSEs) in the relationships among emotional demands, emotional dissonance, and depersonalization. Data were collected from a non-random sample of 423 teachers who worked in primary, secondary, and higher education institutions. Results from structural equation modeling analysis showed that CSEs displayed both direct and indirect effects on depersonalization through employees' perceptions and reactions to emotional labor. Specifically, those individuals with more positive CSEs tended to perceive the emotional aspects of their job as less demanding, thus being less likely to experience emotional dissonance and, in turn, depersonalization. This research demonstrated that CSEs play a vital role in explaining employees' reactions to emotional labor and, therefore, their effects should be properly accounted for in future studies. Implications for practice and future lines of research are discussed in this paper.
Nitrogen fertilizer value of animal slurries with different proportions of liquid and solid fractions: A 3-year study under field conditions
Authors: Pedersen Betina Nørgaard , Christensen Bent T. , Bechini Luca , Cavalli Daniele , Eriksen Jørgen , Sørensen Peter 
Published: February 2021

AbstractThe plant availability of manure nitrogen (N) is influenced by manure composition in the year of application whereas some studies indicate that the legacy effect in following years is independent of the composition. The plant availability of N in pig and cattle slurries with variable contents of particulate matter was determined in a 3-year field study. We separated cattle and a pig slurry into liquid and solid fractions by centrifugation. Slurry mixtures with varying proportions of solid and liquid fraction were applied to a loamy sand soil at similar NH4+-N rates in the first year. Yields and N offtake of spring barley and undersown perennial ryegrass were compared to plots receiving mineral N fertilizer. The first year N fertilizer replacement value (NFRV) of total N in slurry mixtures decreased with increasing proportion of solid fraction. The second and third season NFRV averaged 6.5% and 3.8% of total N, respectively, for cattle slurries, and 18% and 7.5% for pig slurries and was not related to the proportion of solid fraction. The estimated net N mineralization of residual organic N increased nearly linearly with growing degree days (GDD) with a rate of 0.0058%/GDD for cattle and 0.0116%/GDD for pig slurries at 2000–5000 GDD after application. In conclusion NFRV of slurry decreased with increasing proportion of solid fraction in the first year. In the second year, NFRV of pig slurry N was significantly higher than that of cattle slurry N and unaffected by proportion between solid and liquid fraction.
Relevance of level IIb neck dissection in patients with papillary thyroid carcinoma
Authors: Hosokawa S , Takahashi G , Okamura J , Imai A , Mochizuki D , Ishikawa R , Takizawa Y , Misawa K , Shinmura K , Mineta H 
Published: February 2021

AbstractBackgroundCervical nodal metastasis is a key prognostic factor in patients with papillary thyroid carcinoma. The role of lymph nodes in papillary thyroid carcinoma management and prognosis remains controversial.MethodsLevel IIb lymph nodes obtained from 44 patients with papillary thyroid carcinoma were histopathologically examined retrospectively. Specimens were classified as ipsilateral or contralateral. The number of dissected nodes and prevalence of level IIb metastasis were compared according to pre-operative clinical nodal stage.ResultsIn the node-negative neck, the prevalence of contralateral and ipsilateral IIb nodes was 0 out of 20 and 0 out of 3, respectively. In the node-positive neck, the prevalence of contralateral and ipsilateral IIb nodes was 1 out of 13 (7.70 per cent) and 3 out of 41 (7.32 per cent), respectively. Clinically determined and pathologically confirmed level IIb node negativity were significantly associated. Thirty-four patients (77.3 per cent) developed accessory nerve complications from level IIb dissection.ConclusionLevel IIb neck dissection for papillary thyroid carcinoma may be required if pre-operative examination reveals multilevel, level IIa or suspicious level IIb metastasis.
Poverty transitions in severe mental illness: longitudinal analysis of social drift in China, 1994–2015
Authors: Yu Yue-Hui , Luo Wei , Liu Bo , Kuang Wei-Hong , Davidson Larry , Wan Chan Cecilia Lai , Lu Lin , Xiang Meng-Ze , Ran Mao-Sheng 
Published: February 2021

AbstractBackgroundAlthough poverty associated with severe mental illness (SMI) has been documented in many studies, little long-term evidence of social drift exists. This study aimed to unravel the poverty transitions among persons with SMI in a fast change community in China.MethodsTwo mental health surveys, using the International Classification of Disease (ICD-10), were conducted in the same six townships of Xinjin county, Chengdu, China in 1994 and 2015. A total of 308 persons with SMI identified in 1994 were followed up in 2015. The profiles of poverty transitions were identified and regression modelling methods were applied to determine the predictive factors of poverty transitions.ResultsThe poverty rate of persons with SMI increased from 39.9% to 49.4% in 1994 and 2015. A larger proportion of them had fallen into poverty (27.3%) rather than moved out of it (17.8%). Those persons with SMI who had lost work ability, had physical illness and more severe mental disabilities in 1994, as well as those who had experienced negative changes on these factors were more likely to live in persistent poverty or fall into poverty. Higher education level and medical treatment were major protective factors of falling into poverty.ConclusionsThis study shows long-term evidence on the social drift of persons with SMI during the period of rapid social development in China. Further targeted poverty alleviation interventions should be crucial for improving treatment and mental recovery and alleviating poverty related to SMI.
The development of a measure of orthographic knowledge in the Arabic language: A psychometric evaluation
Authors: Tibi Sana , Fitton Lisa , McIlraith Autumn L. 
Published: February 2021

AbstractAlthough Arabic is an official language in 27 countries, standardized measures to assess Arabic literacy are scarce. The purpose of this research was to examine the item functioning of an assessment of Arabic orthographic knowledge. Sixty novel items were piloted with 201 third grade Arabic-speaking students. Participants were asked to identify the correctly spelled word from a pair of two words. Although the assessment was designed to be unidimensional, competing models were tested to determine whether item performance was attributable to multidimensionality. No multidimensional structure fit the data significantly better than the unidimensional model. The 60 original items were evaluated through item fit statistics and comparing performance against theoretical expectations. Twenty-eight items were identified as functioning poorly and were iteratively removed from the scale, resulting in a 32-item set. A value of 0.987 was obtained for McDonald’s coefficient ω from this final scale. Participants’ scores on the measure correlated with an external word reading accuracy measure at 0.79 (p < .001), suggesting that the tool may measure skills important to word reading in Arabic. The task is simple to score and can discriminate among children with below-average orthographic knowledge. This work provides a foundation to develop Arabic literacy assessments.
Food security and food practices in later life: a new model of vulnerability
Authors: Dickinson Angela , Wills Wendy , Kapetanaki Ariadne Beatrice , Ikioda Faith , Godfrey-Smythe Amy , Halliday Sue Vaux 
Published: February 2021

AbstractThe older population is particularly susceptible to malnutrition, which currently affects 1.3 million people aged 65+ in the United Kingdom. Malnutrition is an outcome of food insecurity and despite demographic changes that have led to a rise in numbers of older people, we know very little about how older people become vulnerable to food insecurity. The aim of this study was therefore to explore older people's everyday food practices in order to expose the strengths and challenges within local and national food systems, and better understand how food insecurity might arise in later life. This empirical study operationalised practice theory using a multi-method ethnographic approach with 25 households aged 60–94 years, comprising interviews, observation, visual methods and food logs. A model of vulnerability developed by Schröder-Butterfill and Marianti framed data collection and analysis. Analysis revealed the assets and adaptations older households used to protect themselves from threats to food security. Factors ranging from changes to physical and mental health, and structural factors such as supermarket design, moved households towards food insecurity. Smaller everyday ‘trivia’, e.g. lack of seating and accessible toilets in supermarkets, accumulated to shift people towards vulnerability. Vulnerability is structured by the habitus but is a fluid, relational, temporal and socially constructed state, and people moved towards and away from vulnerability. We have developed a model that accommodates this fluidity, incorporates the concept of ‘cumulative trivia’ and suggests how the ‘aggregation of marginal gains’ could counter-balance and address trivial threats. This model demonstrates to policy makers and those working in public health how vulnerability to food insecurity operates and where interventions could be applied to support households to achieve food security and avoid becoming malnourished.
Stent compression during resuscitation of a neonate with complex heart disease: fatal outcome
Authors: Krasemann Thomas , Verdijk Robert M. , Bartelds Beatrijs 
Published: February 2021

AbstractA newborn with hypoplastic left heart underwent a Norwood operation. Obstruction of the Blalock–Thomas–Taussig shunt was treated with a stent. During resuscitation, this was compressed, which contributed to a fatal outcome.
Terrorism in Australia: A Decade of Escalating Deaths and Injuries Supporting the Need for Counter-Terrorism Medicine
Authors: Tin Derrick , Hart Alexander , Hertelendy Attila J. , Ciottone Gregory R. 
Published: February 2021

AbstractBackground:Australia is ranked 71st on the Global Terrorism Index (GTI; 2019), a scoring system of terrorist activities. While it has a relatively low terrorist risk, events globally have wide-ranging repercussions putting first responders and emergency health workers at risk. Counter-Terrorism Medicine (CTM) is rapidly emerging as a sub-specialty needed to address these threats on the front line. This study aims to provide the epidemiological context for the past decade, detailing the unique injury types responders are likely to encounter, and to develop training programs utilizing these data.Methods:The Global Terrorism Database (GTD) was searched for all attacks in Australia from the years 2009-2019. Attacks met inclusion criteria if they fulfilled the following terrorism-related criteria as set by the GTD. Ambiguous events were excluded when there was uncertainty as to whether the incident met all of the criteria for inclusion as a GTD terrorist incident. The grey literature was reviewed, and each event was cross-matched with reputable international and national newspaper sources online to confirm or add details regarding weapon type used, and whenever available, details of victim and perpetrator fatalities and injuries.Results:Thirty-seven terrorist events occurred in the study time period. Of the thirty-seven incidents, twenty-six (70.2%) involved incendiary weapons, five (13.5%) involved firearms, four (10.8%) involved melee (bladed weapon/knife) attacks, two (5.4%) were explosive/bombing/dynamite attacks, and one (2.7%) was a mixed attack using both incendiary and melee weapons. All except one firearms-related incident (four out of five) resulted in either a fatality or injury or both. Every melee incident resulted in either a fatality or injury or both.Conclusions:In the decade from 2009 to 2019, terrorist attacks on Australian soil have been manageable, small-scale incidents with well-understood modalities. Eleven fatalities and fourteen injuries were sustained as a result of terrorist events during that period. Incendiary weapons were the most commonly chosen methodology, followed by firearms, bladed weapons, and explosive/bombings/dynamite attacks.
Cardiovascular Variability and Reactivity in Major Depressive Disorder
Authors: Duschek Stefan , Bair Angela , Hoffmann Alexandra , Marksteiner Josef , Montoro Casandra I. , Reyes del Paso Gustavo A. 
Published: February 2021

Abstract. This study investigated cardiovascular variability and stress reactivity in major depressive disorder (MDD). While previous research has documented reduced heart rate variability, knowledge about blood pressure variability in MDD remains scarce. Regarding reactivity, a particular focus was placed on the time courses of the cardiovascular responses, which may provide insight into the autonomic mechanisms underlying the hypo-reactivity expected in MDD. In 76 MDD patients and 71 healthy controls, blood pressure was continuously recorded at rest and during mental stress induced by a 3-min serial subtraction task. Compared to controls, patients exhibited lower systolic and diastolic blood pressure, heart rate variability, and systolic and diastolic blood pressure variability. Moreover, smaller stress-related changes in heart rate, systolic and diastolic blood pressure, and sensitivity of the cardiac baroreflex arose in patients. Cardiovascular parameters did not differ between patients using antidepressants and unmedicated patients. According to time-course analysis, reduced hemodynamic modulations in MDD mainly occurred after 50 s of the stress period. Low heart rate variability in MDD reflects deficient top-down integration of the brain mechanisms allowing flexible autonomic and behavioral control; diminished blood pressure variability is indicative of poor homeostatic capacity with respect to the regulation of blood pressure and organ perfusion. Moreover, blunted cardiovascular reactivity implies poor adjustment of energetic resources to internal and environmental demands and may be a correlate of deficient motivational dynamics characterizing MDD. While cardiovascular hypo-reactivity in MDD may be mediated by baroreflex and adrenergic mechanisms, the fast-acting parasympathetic system may play a subordinate role.
Filling the Gap in Cascadia: The Emergence of Low‐Amplitude Long‐Term Slow Slip
Authors: Nuyen Carolyn P. , Schmidt David A. 
Published: February 2021

AbstractLong‐term slow slip events have been observed at several subduction zones around the globe, where they play an integral part in strain release along megathrust faults. Nevertheless, evidence for long‐term slow slip has remained elusive in the Cascadia subduction zone. Here we conduct a systematic analysis of 13 years of GNSS time series data from 2006 to 2019 and present evidence of at least one low‐amplitude long‐term slow slip event on the Cascadia subduction zone, with the possibility of others that are less resolved. Starting in mid‐2012, a 1.5‐year transient is observed in southern Cascadia, with a group of coastal GNSS stations moving ∼2 mm to the west. The data are modeled as a Mw 6.4 slow slip event occurring at 15–35 km depth on the plate interface, just updip of previously recognized short‐term slow slip and tremor. The event shares many characteristics with similar long‐term transient events on the Nankai subduction zone. However, the total fault slip amplitude is an order‐of‐magnitude smaller in Cascadia when compared to large events elsewhere, making long‐term slow slip detection challenging in Cascadia. While there are other westward long‐duration transients in the refined data set, the surface displacements are below the level of the noise or are limited spatially to a few neighboring stations, making interpretation unclear.