bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equilibrium density matrices for the 2D black hole sigma models from an integrable spin chain
Authors: Bazhanov Vladimir V. , Kotousov Gleb A. , Lukyanov Sergei L. 
Published: March 2021

Abstract
This work concerns the quantum Lorentzian and Euclidean black hole non-linear sigma models. For the Euclidean black hole sigma model an equilibrium density matrix is proposed, which reproduces the modular invariant partition function from the 2001 paper of Maldacena, Ooguri and Son. For the Lorentzian black hole sigma model, using its formulation as a gauged SL(2, ℝ) WZW model, we describe the linear and Hermitian structure of its space of states and also propose an expression for the equilibrium density matrix. Our analysis is guided by the results of the study of a certain critical, integrable spin chain. In the scaling limit, the latter exhibits the key features of the Lorentzian black hole sigma model including the same global symmetries, the same algebra of extended conformal symmetry and a continuous spectrum of conformal dimensions.
Heavy neutrino-antineutrino oscillations in quantum field theory
Authors: Antusch Stefan , Rosskopp Johannes 
Published: March 2021

Abstract
It has been proposed that the coherent propagation of long-lived heavy neutrino mass eigenstates can lead to an oscillating rate of lepton number conserving (LNC) and violating (LNV) events, as a function of the distance between the production and displaced decay vertices. We discuss this phenomenon, which we refer to as heavy neutrino-antineutrino oscillations, in the framework of quantum field theory (QFT), using the formalism of external wave packets. General formulae for the oscillation probabilities and the number of expected events are derived and the coherence and localisation conditions that have to be satisfied in order for neutrino-antineutrino oscillations to be observable are discussed. The formulae are then applied to a low scale seesaw scenario, which features two nearly mass degenerate heavy neutrinos that can be sufficiently long lived to produce a displaced vertex when their masses are below the W boson mass. The leading and next-to-leading order oscillation formulae for this scenario are derived. For an example parameter point used in previous studies, the kinematics of the considered LNC/LNV processes are simulated, to check that the coherence and localisation conditions are satisfied. Our results show that the phenomenon of heavy neutrino-antineutrino oscillations can indeed occur in low scale seesaw scenarios and that the previously used leading order formulae, derived with a plane wave approach, provide a good approximation for the considered example parameter point.
On the Explicit Solutions of Separation of Variables Type for the Incompressible 2D Euler Equations
Authors: Saleva Tomi , Tuomela Jukka 
Published: March 2021

AbstractWe study explicit solutions to the 2 dimensional Euler equations in the Lagrangian framework. All known solutions have been of the separation of variables type, where time and space dependence are treated separately. The first such solutions were known already in the 19th century. We show that all the solutions known previously belong to two families of solutions and introduce three new families of solutions. It seems likely that these are all the solutions that are of the separation of variables type.
Sharp Interface Limit of a Stokes/Cahn–Hilliard System, Part II: Approximate Solutions
Authors: Abels Helmut , Marquardt Andreas 
Published: March 2021

AbstractWe construct rigorously suitable approximate solutions to the Stokes/Cahn–Hilliard system by using the method of matched asymptotics expansions. This is a main step in the proof of convergence given in the first part of this contribution, [3], where the rigorous sharp interface limit of a coupled Stokes/Cahn–Hilliard system in a two dimensional, bounded and smooth domain is shown. As a novelty compared to earlier works, we introduce fractional order terms, which are of significant importance, but share the problematic feature that they may not be uniformly estimated in $$\epsilon $$
ϵ
in arbitrarily strong norms. As a consequence, gaining necessary estimates for the error, which occurs when considering the approximations in the Stokes/Cahn–Hilliard system, is rather involved.
The Navier–Stokes–Vlasov–Fokker–Planck System as a Scaling Limit of Particles in a Fluid
Authors: Flandoli Franco , Leocata Marta , Ricci Cristiano 
Published: March 2021

AbstractConvergence of a system of particles, interacting with a fluid, to Navier–Stokes–Vlasov–Fokker–Planck system is studied. The interaction between particles and fluid is described by Stokes drag force. The empirical measure of particles is proved to converge to the Vlasov–Fokker–Planck component of the system and the velocity of the fluid coupled with the particles converges in the uniform topology to the the Navier–Stokes component. A new uniqueness result for the PDE system is added.
Digitale Versorgungsformen zur Personalisierung der stationsäquivalenten Behandlung
Authors: Rauschenberg Christian , Hirjak Dusan , Ganslandt Thomas , Schulte-Strathaus Julia C. C. , Schick Anita , Meyer-Lindenberg Andreas , Reininghaus Ulrich 
Published: March 2021

ZusammenfassungHintergrundDie stationsäquivalente psychiatrische Behandlung (StäB) wurde 2018 als Krankenhausleistung für Menschen eingeführt, die die Kriterien einer stationären Behandlung erfüllen. Die rasanten Fortschritte im Bereich der Informations- und Kommunikationstechnologie bieten neue Chancen für innovative digitale Versorgungsangebote wie telemedizinische, eHealth- oder mHealth-Verfahren.Ziel der ArbeitDiese Übersichtsarbeit soll einen umfassenden Überblick über neue digitale Versorgungsformen geben, die zur Personalisierung der StäB bei schweren psychischen Erkrankungen beitragen und somit klinische und soziale Outcomes verbessern sowie direkte und indirekte Kosten reduzieren könnten.MethodeDiese Arbeit basiert auf einer selektiven Literaturrecherche (Narratives Review).ErgebnisseEs wurden vier primäre digitale Versorgungsformen identifiziert, die in der StäB gewinnbringend genutzt werden könnten: (1) Kommunikation, Behandlungskontinuität und -flexibilität durch Online-Chat und Videotelefonie, (2) Monitoring von Symptomen und Verhaltensweisen in Echtzeit durch Anwendung des ambulatorischen Assessments („ecological momentary assessment“ [EMA]), (3) Nutzung multimodaler EMA-Daten für die Generierung von personalisiertem Feedback über subjektives Erleben und Verhaltensmuster sowie (4) auf Person, Moment und Kontext zugeschnittene, adaptive ambulatorische Interventionen („ecological momentary interventions“ [EMIs]).DiskussionDigitale Versorgungsformen haben erhebliches Potenzial die Effektivität und Kosteneffektivität der StäB zu steigern. Ein wichtiger nächster Schritt besteht darin, die Anwendung dieser Versorgungsformen im Bereich der StäB zu modellieren und deren Qualität aus Sicht der Patient*innen, Sicherheit und initiale Prozess- und Ergebnisqualität sowie Implementierungsbedingungen sorgfältig zu untersuchen.
Using wild relatives and related species to build climate resilience in Brassica crops
Authors: Quezada-Martinez Daniela , Addo Nyarko Charles P. , Schiessl Sarah V. , Mason Annaliese S. 
Published: March 2021

AbstractClimate change will have major impacts on crop production: not just increasing drought and heat stress, but also increasing insect and disease loads and the chance of extreme weather events and further adverse conditions. Often, wild relatives show increased tolerances to biotic and abiotic stresses, due to reduced stringency of selection for yield and yield-related traits under optimum conditions. One possible strategy to improve resilience in our modern-day crop cultivars is to utilize wild relative germplasm in breeding, and attempt to introgress genetic factors contributing to greater environmental tolerances from these wild relatives into elite crop types. However, this approach can be difficult, as it relies on factors such as ease of hybridization and genetic distance between the source and target, crossover frequencies and distributions in the hybrid, and ability to select for desirable introgressions while minimizing linkage drag. In this review, we outline the possible effects that climate change may have on crop production, introduce theBrassicacrop species and their wild relatives, and provide an index of useful traits that are known to be present in each of these species that may be exploitable through interspecific hybridization-based approaches. Subsequently, we outline how introgression breeding works, what factors affect the success of this approach, and how this approach can be optimized so as to increase the chance of recovering the desired introgression lines. Our review provides a working guide to the use of wild relatives and related crop germplasm to improve biotic and abiotic resistances inBrassicacrop species.
Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia
Authors: Vickneson Keeran , Blackburn Jessica , Gallagher Jennifer R. , Evans Mark L. , de Galan Bastiaan E. , Pedersen-Bjergaard Ulrik , Thorens Bernard , McNeilly Alison D. , McCrimmon Rory J. 
Published: March 2021

Abstract
Aims/hypothesis
Recurrent hypoglycaemia in people with diabetes leads to progressive suppression of counterregulatory hormonal responses to subsequent hypoglycaemia. Recently it has been proposed that the mechanism underpinning this is a form of adaptive memory referred to as habituation. To test this hypothesis, we use two different durations of cold exposure to examine whether rodents exposed to recurrent hypoglycaemia exhibit two characteristic features of habituation, namely stimulus generalisation and dishabituation.

Methods
In the first study (stimulus generalisation study), hyperinsulinaemic–hypoglycaemic (2.8 mmol/l) glucose clamps were performed in non-diabetic rodents exposed to prior moderate-duration cold (4°C for 3 h) or control conditions. In the second study (dishabituation study), rodents exposed to prior recurrent hypoglycaemia or saline (154 mmol/l NaCl) injections over 4 weeks underwent a longer-duration cold (4°C for 4.5 h) exposure followed 24 h later by a hyperinsulinaemic–hypoglycaemic (2.8 mmol/l) glucose clamp. Output measures were counterregulatory hormone responses during experimental hypoglycaemia.

Results
Moderate-duration cold exposure blunted the adrenaline (epinephrine) response (15,266 ± 1920 vs 7981 ± 1258 pmol/l, Control vs Cold; p < 0.05) to next day hypoglycaemia in healthy non-diabetic rodents. In contrast, the suppressed adrenaline response (Control 5912 ± 1417 vs recurrent hypoglycaemia 1836 ± 736 pmol/l; p < 0.05) that is associated with recurrent hypoglycaemia was restored following longer-duration cold exposure (recurrent hypoglycaemia + Cold 4756 ± 826 pmol/l; not significant vs Control).

Conclusions/interpretation
Non-diabetic rodents exhibit two cardinal features of habituation, namely stimulus generalisation and dishabituation. These findings provide further support for the hypothesis that suppressed counterregulatory responses following exposure to recurrent hypoglycaemia in diabetes result from habituation.

Graphical abstract
Solitäre lokoregionäre Metastase eines undifferenzierten pleomorphen Sarkoms im M. quadratus femoris
Authors: Bdeir Mohamad , Vassos Nikolaos , Darwich Ali , Weis Cleo-Aron , Gravius Sascha , Renker Eva 
Published: March 2021

ZusammenfassungDas undifferenzierte pleomorphe Sarkom („undifferentiated pleomorphic sarcoma“ [UPS]) gehört zur Gruppe der Weichteilsarkome und macht fast 10 % aller Weichteilsarkome aus. Der Fall eines 49-jährigen Patienten wird vorgestellt, bei dem die kompartmentorientierte Resektion eines primären UPS im linken Musculus gluteus maximus mit adjuvanter Radiotherapie (60 Gy) durchgeführt wurde. Im Rahmen der Tumornachsorge (3 Jahre später) wurde eine lokoregionäre Metastase an einer ungewöhnlichen Lokalisation im M. quadratus femoris festgestellt, welche mittels einer In-toto-Resektion mit intraoperativer Radiotherapie (10 Gy) behandelt wurde. Der intra- und postoperative Verlauf gestalten sich komplikationslos ohne neurologische Defizite. Im Rahmen der Nachtuntersuchung 6 Monate postoperativ war der Patient tumor- und beschwerdefrei.
Internal face finishing for a cooling channel using a fluid containing free abrasive grains
Authors: Yamaguchi Mitsugu , Furumoto Tatsuaki , Inagaki Shuuji , Tsuji Masao , Ochiai Yoshiki , Hashimoto Yohei , Koyano Tomohiro , Hosokawa Akira 
Published: March 2021

AbstractIn die-casting and injection molding, a conformal cooling channel is applied inside the dies and molds to reduce the cycle time. When the internal face of the channel is rough, both cooling performance and tool life are negatively affected. Many methods for finishing the internal face of such channels have been proposed. However, the effects of the channel diameter on the flow of a low-viscosity finishing media and its finishing characteristics for H13 steel have not yet been reported in the literature. This study addresses these deficiencies through the following: the fluid flow in a channel was computationally simulated; the flow behavior of abrasive grains was observed using a high-speed camera; and the internal face of the channel was finished using the flow of a fluid containing abrasive grains. The flow velocity of the fluid with the abrasive grains increases as the channel diameter decreases, and the velocity gradient is low throughout the channel. This enables reduction in the surface roughness for a short period and ensures uniform finishing in the central region of the channel; however, over polishing occurs owing to the centrifugal force generated in the entrance region, which causes the form accuracy of the channel to partially deteriorate. The outcomes of this study demonstrate that the observational finding for the finishing process is consistent with the flow simulation results. The flow simulation can be instrumental in designing channel diameters and internal pressures to ensure efficient and uniform finishing for such channels.
Tracing the origin of paracetamol tablets by near-infrared, mid-infrared, and nuclear magnetic resonance spectroscopy using principal component analysis and linear discriminant analysis
Authors: Becht Alexander , Schollmayer Curd , Monakhova Yulia , Holzgrabe Ulrike 
Published: March 2021

AbstractMost drugs are no longer produced in their own countries by the pharmaceutical companies, but by contract manufacturers or at manufacturing sites in countries that can produce more cheaply. This not only makes it difficult to trace them back but also leaves room for criminal organizations to fake them unnoticed. For these reasons, it is becoming increasingly difficult to determine the exact origin of drugs. The goal of this work was to investigate how exactly this is possible by using different spectroscopic methods like nuclear magnetic resonance and near- and mid-infrared spectroscopy in combination with multivariate data analysis. As an example, 56 out of 64 different paracetamol preparations, collected from 19 countries around the world, were chosen to investigate whether it is possible to determine the pharmaceutical company, manufacturing site, or country of origin. By means of suitable pre-processing of the spectra and the different information contained in each method, principal component analysis was able to evaluate manufacturing relationships between individual companies and to differentiate between production sites or formulations. Linear discriminant analysis showed different results depending on the spectral method and purpose. For all spectroscopic methods, it was found that the classification of the preparations to their manufacturer achieves better results than the classification to their pharmaceutical company. The best results were obtained with nuclear magnetic resonance and near-infrared data, with 94.6%/99.6% and 98.7/100% of the spectra of the preparations correctly assigned to their pharmaceutical company or manufacturer.
Graphical abstract
Conventional MRI findings in hereditary degenerative ataxias: a pictorial review
Authors: Cocozza Sirio , Pontillo Giuseppe , De Michele Giovanna , Di Stasi Martina , Guerriero Elvira , Perillo Teresa , Pane Chiara , De Rosa Anna , Ugga Lorenzo , Brunetti Arturo 
Published: March 2021

Abstract
Purpose
Cerebellar ataxias are a large and heterogeneous group of disorders. The evaluation of brain parenchyma via MRI plays a central role in the diagnostic assessment of these conditions, being mandatory to exclude the presence of other underlying causes in determining the clinical phenotype. Once these possible causes are ruled out, the diagnosis is usually researched in the wide range of hereditary or sporadic ataxias.

Methods
We here propose a review of the main clinical and conventional imaging findings of the most common hereditary degenerative ataxias, to help neuroradiologists in the evaluation of these patients.

Results
Hereditary degenerative ataxias are all usually characterized from a neuroimaging standpoint by the presence, in almost all cases, of cerebellar atrophy. Nevertheless, a proper assessment of imaging data, extending beyond the mere evaluation of cerebellar atrophy, evaluating also the pattern of volume loss as well as concomitant MRI signs, is crucial to achieve a proper diagnosis.

Conclusion
The integration of typical neuroradiological characteristics, along with patient’s clinical history and laboratory data, could allow the neuroradiologist to identify some conditions and exclude others, addressing the neurologist to the more appropriate genetic testing.
Biophysical characterization of melanoma cell phenotype markers during metastatic progression
Authors: Sobiepanek Anna , Paone Alessio , Cutruzzolà Francesca , Kobiela Tomasz 
Published: March 2021

AbstractMelanoma is the most fatal form of skin cancer, with increasing prevalence worldwide. The most common melanoma genetic driver is mutation of the proto-oncogene serine/threonine kinase BRAF; thus, the inhibition of its MAP kinase pathway by specific inhibitors is a commonly applied therapy. However, many patients are resistant, or develop resistance to this type of monotherapy, and therefore combined therapies which target other signaling pathways through various molecular mechanisms are required. A possible strategy may involve targeting cellular energy metabolism, which has been recognized as crucial for cancer development and progression and which connects through glycolysis to cell surface glycan biosynthetic pathways. Protein glycosylation is a hallmark of more than 50% of the human proteome and it has been recognized that altered glycosylation occurs during the metastatic progression of melanoma cells which, in turn facilitates their migration. This review provides a description of recent advances in the search for factors able to remodel cell metabolism between glycolysis and oxidative phosphorylation, and of changes in specific markers and in the biophysical properties of cells during melanoma development from a nevus to metastasis. This development is accompanied by changes in the expression of surface glycans, with corresponding changes in ligand-receptor affinity, giving rise to structural features and viscoelastic parameters particularly well suited to study by label-free biophysical methods.
Impact of Bypass Flow Assessment on Long‐Term Outcomes in Patients with Chronic Limb‐Threatening Ischemia
Authors: Cinara Ilijas , Zlatanovic Petar , Sladojevic Milos , Tomic Ivan , Mutavdzic Perica , Ducic Stefan , Vujcic Aleksandra , Davidovic Lazar 
Published: March 2021

AbstractBackgroundTransit time flow meter (TTFM) allows quick and accurate intraoperative graft assessment. The main study goal is to evaluate the influence of graft flow measurements on long‐term clinical outcomes in patients with chronic limb‐threatening ischemia (CLTI) undergoing bellow the knee (BTK) vein bypass surgery.MethodsBetween January 1st, 1999 and January 1st, 2006, 976 CLTI consecutive patients underwent lower extremity bypass surgery. When applying the exclusion criteria, 249 patients were included in the final analysis. Control measurements were performed at the end of the procedure. Patients were divided according to the mean (more/less than 100 ml/min) and diastolic graft flow (more/less than 40 ml/min) values in four groups. The primary endpoints were a major adverse limb event (male) and primary graft patency.ResultsAfter the median follow‐up of 68 months, a group with the mean graft flow below 100 ml/min and the diastolic graft flow below 40 ml/min had the highest rates of male (χ2 = 36.60, DF = 1, P < 0.01, log‐rank test) and the worst primary graft patency (χ2 = 53.05, DF = 1, P < 0.01, log‐rank test).ConclusionIn patients with CLTI undergoing BTK vein bypass surgery, TTFM parameters, especially combined impact of mean graft flow less than 100 ml/min and diastolic graft flow less than 40 ml/min, were associated with an increased risk of poor long‐term male and primary graft patency.
Risk Factors for Anastomotic Leakage in Patients with Rectal Tumors Undergoing Anterior Resection within an ERAS Protocol: Results from the Swedish ERAS Database
Authors: Asklid Daniel , Ljungqvist Olle , Xu Yin , Gustafsson Ulf O. 
Published: March 2021

AbstractBackgroundResearch on risk factors for anastomotic leakage (AL) alone within an Enhanced Recovery After Surgery (ERAS) protocol has not yet been conducted. The aim of this study was to identify risk factors for AL and study short‐term outcome after AL in patients operated with anterior resection (AR).MethodsAll prospectively and consecutively recorded patients operated with AR in the Swedish part of the international ERAS® Interactive Audit System (EIAS) between January 2010 and February 2020 were included. The cohort was evaluated regarding risk factors for AL and short‐term outcomes, including uni‐ and multivariate analysis. Pre‐, intra‐ and postoperative compliance to ERAS®Society guidelines was calculated and evaluated.ResultsAltogether 1900 patients were included, 155 (8.2%) with AL and 1745 without AL. Male gender, obesity, peritoneal contamination, year of surgery 2016–2020, duration of primary surgery and age remained significant predictors for AL in multivariate analysis. There was no significant difference in overall pre‐ and intraoperative compliance to ERAS®Society guidelines between groups. Only preadmission patient education remained as a significant ERAS variable associated with less AL. AL was associated with longer length of stay (LOS), higher morbidity rate and higher rate of reoperations.ConclusionMale gender, obesity, peritoneal contamination, duration of surgery, surgery later in study period, age and preadmission patient education were associated with AL in patients operated on with AR. Overall pre‐ and intraoperative compliance to the ERAS protocol was high in both groups and not associated with AL.