bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients’ experiences in early satiety after total gastrectomy for gastric cancer: a phenomenological study
Authors: Vaccaro Salvatore , Díaz Crescitelli Matías Eduardo , Mastrangelo Stefano , Fornaciari Nadia , Reverberi Elisabetta , Di Leo Silvia , Ghirotto Luca 
Published: January 2025

IntroductionThis study examines how gastric cancer patients adjust their eating habits and quality of life after total gastrectomy, particularly concerning early satiety. While total gastrectomy may provide a potential cure, it also leads to significant physical, psychological, and social changes. Understanding these adaptations is essential for enhancing survivorship care.MethodsWe conducted a qualitative study utilizing a phenomenological approach to gain insights into the lived experiences of gastric cancer patients following total gastrectomy. Semi-structured interviews were analyzed to identify key themes related to eating habits and quality of life.ResultsFour core themes emerged: (1) Ineluctability of bodily transformations—patients experienced significant disruptions to their bodily identity; (2) Feelings of weaning and loss of habits—a sense of mourning for lost routines and pleasures; (3) Redefining habits—the process of adapting to new eating patterns; and (4) Experiencing tentative conviviality—struggles to restore social interactions around meals. Social anxiety, particularly regarding dining outside the home, was a notable challenge. Family caregivers played complex roles, providing both support and unintentional obstacles.DiscussionThe findings highlight the multifaceted impact of total gastrectomy on patients’ lives, influencing their physical health, psychological well-being, and social dynamics. Survivorship care plans should consider these aspects to facilitate adaptation. Targeted interventions, such as nutritional counseling, telemonitoring, and digital tools, are suggested to assist patients in adjusting to post-gastrectomy life. These strategies could enhance quality of life and promote improved physical, psychological, and social well-being integration.
Bioequivalence study of fluticasone propionate nebuliser suspensions in healthy Chinese subjects
Authors: Cheng Feng , Shen Tao , Zhang Fucheng , Lei Chenghao , Zhu Ye , Luo GuoJun , Xiao Dawei 
Published: January 2025

BackgroundFluticasone propionate is a synthetic trifluoro-substituted glucocorticoid, a highly selective glucocorticoid receptor agonist. Fluticasone propionate nebuliser suspensions is an inhaled corticosteroid with the low systemic bioavailability which provides a low risk (benefit outcome without the adverse effects that accompany systemically administered corticosteroids), referred as a first-line preventive agent for patients with persistent asthma. China has become one of the countries with the highest asthma mortality rate in the world in the past years. It urgently needs good generic drugs to help ease patients’ burden and improve their quality of life.ObjectiveThe primary objective of this study was to evaluate the bioequivalence of fluticasone propionate nebuliser suspensions between test formulation (generic product) and reference formulation (original product, Flixotide Nebules®) with the pharmacokinetic parameters as the endpoint indicators and the secondary objective was to evaluate the safety of two inhalated fluticasone propionate nebuliser suspensions under the condition of fasting in healthy Chinese subjects.MethodsThe bioequivalence study was conducted with a single-center, randomized, open-label, single-dose, two sequences, two-period crossover design. 24 healthy subjects were randomly assigned into T-R and R-T sequence groups with 12 patients in each group. The subjects were administered 1 mg (2 mL:0.5 mg,plastic ampoules) of generic fluticasone propionate nebuliser suspension as a test formulation or Flixotide Nebules® as reference formulation and cross administration after sufficient washout period (5 days) for the second period study. The blood sample was collected at predetermined time points up to 48 h and the plasma concentration of fluticasone propionate was determined by HPLC-MS/MS in healthy subjects after inhalation of test or reference formulation. The non-compartment model method (NCA module) of the WinNonlin® software (version 8.3) was used to calculate the pharmacokinetic parameters (Cmax, AUC0-t, AUC0-∞) between the test formulation and the reference formulation were within the predefined range of 80.00% and 125.00%, bioequivalence of both formulations was demonstrated.ResultsThe 90% confidence intervals of the T/R ratio of the geometric mean of Cmax, AUC0-t, and AUC0-∞ for both formulations were 90.24%–112.68%, 96.99%–112.27% and 96.41%–111.59% respectively, which were all within the bioequivalent range of 80%–125%. No severe, suspicious or unexpected serious adverse reactions were reported.ConclusionThe test and reference formulations of fluticasone propionate nebuliser suspension were pharmacokinetic bioequivalent and were well tolerated and safe in all subjects.
Network meta-analysis of efficacy and safety of drugs for the treatment of moderate to severe ulcerative colitis
Authors: Zhang Wenkai , Zhao Songbo , Li Jipin , Sun Yihua , Wang Xiang 
Published: January 2025

PurposeTo guide the drug selection for treatment of moderate to severe ulcerative colitis (UC) by evaluating the efficacy and safety of various drugs.MethodsThis systematic review searched the Embase, PubMed, The Cochrane Library, and Web of Science databases and included randomized controlled trials (RCTs) based on the drugs used alone or in combination for treating UC. Moreover, the Stata17.0 software was employed for statistical analysis and results were reported as relative risk (RR) and 95% confidence interval (CI).ResultsFor the efficacy of induction, upadacitinib ranked first in clinical response, clinical remission, and endoscopic improvement rates, with cumulative probabilities of 96.0%, 99.3%, and 99.0%, respectively. Moreover, for the efficacy of maintenance, upadacitinib ranked first in both clinical remission and endoscopic improvement with a cumulative probability of 93.2% and 93.3%, respectively. For safety, vedolizumab showed the best incidence of adverse events (AE) with 16.8% cumulative probability, while upadacitinib showed the best incidence of serious adverse events (SAE) with 13.8% cumulative probability.ConclusionIn a systematic review and network meta-analysis, we found upadacitinib showed the best efficacy and safety in to be ranked highest in patients with moderate to severe ulcerative colitis. More trials of direct comparisons are needed to inform clinical decision making with greater confidence.
α-Bisabolol alleviates diesel exhaust particle-induced lung injury and mitochondrial dysfunction by regulating inflammatory, oxidative stress, and apoptotic biomarkers through the c-Jun N-terminal kinase signaling pathway
Authors: Beegam Sumaya , Zaaba Nur Elena , Elzaki Ozaz , Nemmar Abderrahim 
Published: January 2025

IntroductionExposure to particulate matter ≤2.5 μm in diameter (PM2.5) is associated with adverse respiratory outcomes, including alterations to lung morphology and function. These associations were reported even at concentrations lower than the current annual limit of PM2.5. Inhalation of PM2.5, of which diesel exhaust particles (DEPs) is a major component, induces lung inflammation and oxidative stress. α-Bisabolol (BIS) is a bioactive dietary phytochemical with various pharmacological properties, including anti-inflammatory and antioxidant actions. Here, we evaluated the possible protective effects of BIS on DEP-induced lung injury.MethodsMice were exposed to DEPs (20 µg/mouse) or saline (control) by intratracheal instillation. BIS was administered orally at two doses (25 and 50 mg/kg) approximately 1 h before DEP exposure. Twenty-four hours after DEP administration, multiple respiratory endpoints were evaluated.ResultsBIS administration was observed to prevent DEP-induced airway hyperreactivity to methacholine; influx of macrophages, neutrophils, and lymphocytes in the bronchoalveolar lavage fluid; and increases in epithelial and endothelial permeabilities. DEP exposure caused increases in the levels of myeloperoxidase, proinflammatory cytokines, and oxidative stress markers in lung tissue homogenates, and all these effects were abated by BIS treatment. The activities of mitochondrial complexes I, II, III, and IV were markedly increased in the lungs of mice exposed to DEPs, and these effects were significantly reduced in the BIS-treated group. Intratracheal instillation of DEPs induced DNA damage and increase in the apoptotic marker cleaved caspase-3. The latter effects were prevented in mice treated with BIS and exposed to DEPs. Moreover, BIS mitigated DEP-induced increase in the expression of phospho-c-Jun N-terminal kinase (JNK) in a dose-dependent manner.DiscussionBIS markedly alleviated DEP-induced lung injury by regulating the inflammatory, oxidative stress, and apoptotic biomarkers through the JNK signaling pathway. Following additional studies, BIS may be considered as a plausible protective agent against inhaled-particle-induced pulmonary adverse effects.
Modulation of gut microbiota, up-regulation of ZO-1, and promotion of metabolism as therapeutic mechanisms of indole-3-carbinol against obesity in mice
Authors: Mao XuWen , Paerhati Guliruoyi , Wu Yuche , Cheng Lu Feng 
Published: January 2025

BackgroundIndole-3-carbinol (I3C) is a compound derived from Cruciferous vegetables. We aim to ascertain whether I3C mediates the relations between mouse gut microbiota, intestinal barrier function, and metabolism to treat obesity in mice.MethodsThe experimental analyses focused on the changes in lipid distribution, inflammatory cytokines, glucose tolerance, gut microbiota composition, and serum metabolomics of 60 C57BL/6N mice.ResultsThe experimental results demonstrated that I3C reduced body weight, hepatic steatosis, and systemic inflammation and improved insulin resistance in mice on a high-fat diet (HFD). Furthermore, I3C remarkably enhanced the enrichment of probiotics Akkermansia and Ligilactobacillus as well as SCFA-producing bacteria (Eubacterium, Lactococcus, and Coprococcus), while reducing the abundance of Eisenbergiella and Rikenellaceae_RC9_gut_group. Also, I3C notably up-regulated the levels of Claudin4, Occludin, and ZO-1 proteins and modulated the metabolism of argininosuccinic acid and galactose.ConclusionThe aforementioned findings suggest that I3C exerts a significant anti-obesity effect in mice by regulating abnormal gut microbiome, enhancing intestinal barrier function, and improving metabolic disorders.
Pathogenesis-directed therapy of methylphenidate-induced oxidative heart damage in rats
Authors: Emir Izzet , Bulut Seval , Suleyman Bahadır , Mammadov Renad , Yucel Nurinisa , Cicek Betul , Yazici Gulce Naz , Altuner Durdu , Gunay Murat , Suleyman Halis 
Published: January 2025

AimThe current study aimed to investigate the protective effects of adenosine triphosphate (ATP), metyrosine, and melatonin on possible methylphenidate cardiotoxicity in rats using biochemical and histopathological methods.MethodsThirty rats were separated into five groups: healthy (HG), methylphenidate (MP), ATP + methylphenidate (ATMP), metyrosine + methylphenidate (MSMP), and melatonin + methylphenidate (MLMP). ATP (5 mg/kg) was given intraperitoneally once daily, metyrosine (50 mg/kg) orally twice daily, and melatonin (10 mg/kg) orally once daily. Methylphenidate (10 mg/kg) was administered orally once daily for 1 h after ATP, metyrosine and melatonin. The protocol was repeated for 30 days. Subsequently, blood samples were taken from the tail veins of the animals to measure adrenaline, noradrenaline, dopamine, troponin I (TP I) and creatine kinase MB (CK-MB) levels; the animals were then euthanized and the heart tissues were extracted. Tissues were analyzed for malondialdehyde (MDA), total glutathione (tGSH), superoxide dismutase (SOD), and catalase (CAT) and histopathologically.ResultsIn MP group, MDA, adrenaline, noradrenaline, dopamine, TP I, and CK-MB levels increased (p &lt; 0.001) and tGSH, SOD, and CAT levels decreased (p &lt; 0.001) compared to HG, and histopathologic damage developed. Oxidant levels were lower and antioxidant levels were higher in ATMP, MSMP, and MLMP groups compared to MP group (p &lt; 0.001). Catecholamine levels were measured lower in the MSMP group compared to the MP group (p &lt; 0.001). TP I and CK-MB levels were lower in ATMP, MSMP and MLMP groups compared to MP (p &lt; 0.05), with the lowest being in rats given ATP (p &lt; 0.001). ATP, melatonin, and metirozin applications were effective to different degrees in preventing histopathological changes.ConclusionThis study may guide clinical trials using ATP and melatonin to prevent methylphenidate-induced myocardial injury.
Drug-induced Parkinson-like events: a real-world study from 2004 to the first quarter of 2024 based on FAERS
Authors: Wang Ke , Chen Junyan , Huang Mingquan , Zeng Xinhao , Ren Xiaoqun , Liu Xiuqiong , Tao Chao , Yang Liuxuan , Shang Jinlu , Zhou Meiling 
Published: January 2025

BackgroundTimely identification of drug-induced Parkinson-like events is essential to improve clinical management and enhance patients’ quality of life. However, there is a significant lack of studies addressing these events in real-world settings.MethodsTo bridge this gap, we analyzed adverse event (AE) reports related to Parkinson-like events from the FDA Adverse Event Reporting System (FAERS) database from the first quarter of 2004 to the first quarter of 2024. Our objective was to summarize a list of potential drugs at high risk for Parkinson-like events and their corresponding proportions of AE reports.ResultsAs a result, a total of 54,639 AE reports linked to Parkinson-like events involving 1,224 drugs were identified. Among these, carbidopa/levodopa exhibited the highest number of reports, followed by baclofen and pimavanserin. The most frequently reported drug class was antiparkinsonian drugs and psycholeptics, followed by psychoanaleptics. Using two disproportionate analysis methods, the reporting odds ratio and proportional reporting ratio, we found that 136 drugs exhibited positive results in both methods, while 1,063 drugs did not show any positive signals.ConclusionThis study provides a comprehensive pharmacovigilance analysis of drugs associated with Parkinson-like events, aiming to promote rational drug use and inform clinical practice.
Meta-analyses of the effects of high-intensity interval training in elite athletes—part I: mean effects on various performance measures
Authors: Wiesinger Hans-Peter , Stöggl Thomas Leonard , Haller Nils , Blumkaitis Julia , Strepp Tilmann , Kilzer Francesca , Schmuttermair Anna , Hopkins Will G. 
Published: January 2025

IntroductionMeta-analysts have found that high-intensity interval training (HIIT) improves physical performance, but limited evidence exists regarding its effects on highly trained athletes, measures beyond maximum oxygen uptake (V˙O2max), and the moderating effects of different types of HIIT. In this study, we present meta-analyses of the effects of HIIT focusing on these deficits.MethodsThe effects of 6 types of HIIT and other moderators were derived from 34 studies involving highly trained endurance and elite athletes in percent units via log-transformation from separate meta-regression mixed models for sprint, time–trial, aerobic/anaerobic threshold, peak speed/power, repeated-sprint ability, V˙O2max, and exercise economy. The level of evidence for effect magnitudes was evaluated based on the effect uncertainty and the smallest important change of 1%.ResultsCompared with control training, HIIT showed good to excellent evidence for the substantial enhancement of most measures for some athlete subgroups in practically important study settings defined by effect moderators (maximum of 12.6%, for endurance female athletes after 6 weeks of aerobic traditional long intervals). The assessment of the moderators indicated good evidence of greater effects as follows: with more aerobic types of HIIT for V˙O2max (+2.6%); with HIIT added to conventional training for most measures (+1.1–2.3%); during the competition phase for V˙O2max (+4.3%); and with tests of longer duration for sprint (+5.5%) and time trial (+4.9%). The effects of sex and type of athlete were unclear moderators. The heterogeneity of HIIT effects within a given type of setting varied from small to moderate (standard deviations of 1.1%–2.3%) and reduced the evidence of benefit in some settings.ConclusionAlthough athletes in some settings can be confident of the beneficial effects of HIIT on some measures related to competition performance, further research is needed. There is uncertainty regarding the mean effects on exercise economy and the modifying effects of sex, duration of intervention, phase of training, and type of HIIT for most measures.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=236384.
Welfare state, social policy and social sustainability, within the context of the permacrisis
Authors: Papadakis Nikos , Tzagkarakis Stylianos Ioannis 
Published: January 2025

IntroductionSustainable development is based on three interrelated and equally important pillars; the environmental, the economic and the social. The social pillar involves building a framework that promotes the well-being of the whole population with the ultimate aim of preserving social cohesion, while reducing social discrimination. In our analysis, the concept of social sustainability refers to the need for the creation of a society that contains all the conditions for sustainable development in terms of equal opportunities for employment and social well-being. Currently, significant problems and dysfunctions exist as long as several European labor markets are fragmented with a strong insiders-outsiders divergence, job-polarization, high labor market slack, high in-work poverty rates especially in precarious forms of employment. In Europe as well as globally, addressing these issues is of major importance in order to ensure social sustainability, given that the permacrisis (multiple crises), along with the Mega-Trends have a clear impact on the structure of economy and labor market, industrial relations systems, and business models.MethodsThe present paper analyses the state of play of social sustainability in Europe and aims to identify specific policy responses that could offer viable solutions to old and emerging challenges in terms of social inclusion through the examination of secondary quantitative data.ResultsThe permacrisis era, along with the Mega-Trends that are taking place and seem to gradually have a clear impact on the structure of economy and labor market, substantially affecting every aspect of society, since social inequalities have the tendency to interrelate and getting reproduced.DiscussionThere is a need for knowledge-based and evidence-informed policy making, both in terms of policy design and implementation, for a true and actual sustainable (as well as inclusive) development, within momentous times.
The psychological resources of success: satisfaction with academic majors, psychological capital, and achievement motivation among future tourism and hospitality leaders
Authors: Alismail Abdulaziz Mohammed , Almulla Mazen Omar , Albohnayh Abdullah Saleh Mohammed , Abdou Ahmed Hassan 
Published: January 2025

IntroductionExploring the factors that drive academic achievement motivation is a vital area in educational psychology, particularly within specialized fields like tourism and hospitality higher education. Achievement motivation, essential for academic and career success, is shaped by various positive psychological resources and contextual factors. Grounded in the framework of positive psychology, this study examines how satisfaction with academic majors (SAT) predicts achievement motivation among tourism and hospitality students in Saudi Arabia. Additionally, the research investigates the mediating role of psychological capital (PsyCap) - a positive psychological construct encompassing hope, optimism, resilience, and self-efficacy - within this relationship.MethodsA quantitative approach was employed using Partial Least Squares Structural Equation Modeling (PLS-SEM). Data were collected from 522 junior and senior undergraduate students enrolled in tourism and hospitality programs across Saudi Arabia. Validated scales were used to measure SAT, PsyCap, and achievement motivation.ResultsThe findings indicate that greater satisfaction with one’s academic major (SAT) positively predicts both PsyCap and achievement motivation. Furthermore, PsyCap was found to be positively and significantly associated with achievement motivation and partially mediate the relationship between SAT and achievement motivation.ConclusionThis study’s findings underscore the vital role of positive psychological resources in empowering students and advancing motivation, offering a validated model that informs future educational studies and interventions within tourism and hospitality while underscoring the significance of fostering psychological well-being in higher education.
The relationship between loneliness and internalizing disorders among young adults: the mediating and moderating role of ego-resilience
Authors: Padmanabhanunni Anita , Pretorius Tyrone B. 
Published: January 2025

BackgroundThe relationship between loneliness and internalizing disorders has been well established in psychological research. This study aims to build on existing research by exploring how different components of loneliness—isolation, relational connectedness, and collective connectedness—interact with ego-resilience to influence anxiety, depression, and hopelessness.MethodsThe study participants were young adults (n = 337) who completed the University of California-Los Angeles Loneliness Scale, Ego Resilience Scale, Centre for Epidemiological Studies Depression Scale, State-Trait Anxiety Scale, and Beck Hopelessness Scale. A regression-based moderation and mediation analysis was used to investigate the relationships between the components of loneliness, ego-resilience, and internalizing disorders.ResultsThe results of correlational analysis demonstrated that the zero-order correlations between the components of loneliness, isolation, relational connectedness, and collective connectedness, on the one hand, and internalizing disorders, on the other hand, were all significant. Mediation analyses found that ego-resilience partly mediated the relationships between relational connectedness and internalizing disorders, the relationships between collective connectedness and internalizing disorders, and the relationships between isolation and internalizing disorders. Further, moderation analyses found that ego-resilience moderated the relationships between collective connectedness and relational connectedness, respectively, and hopelessness.ConclusionThis study highlights the central role of ego-resilience in mediating the effects of different facets of loneliness on internalizing disorders. Understanding the mediating and moderating role of ego-resilience can inform therapeutic approaches and interventions aimed at reducing the impact of loneliness on mental health.