bluuebunny/crossref_metadata_2025_split huggingface dataset:
A model and predictions for COVID-19 considering population behavior and vaccination
Authors: Usherwood Thomas , LaJoie Zachary , Srivastava Vikas 
Published: June 2021

AbstractThe effect of vaccination coupled with the behavioral response of the population is not well understood. Our model incorporates two important dynamically varying population behaviors: level of caution and sense of safety. Level of caution increases with infectious cases, while an increasing sense of safety with increased vaccination lowers precautions. Our model accurately reproduces the complete time history of COVID-19 infections for various regions of the United States. We propose a parameter $$d_I$$

d
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as a direct measure of a population’s caution against an infectious disease that can be obtained from the infectious cases. The model provides quantitative measures of highest disease transmission rate, effective transmission rate, and cautionary behavior. We predict future COVID-19 trends in the United States accounting for vaccine rollout and behavior. Although a high rate of vaccination is critical to quickly ending the pandemic, a return towards pre-pandemic social behavior due to increased sense of safety during vaccine deployment can cause an alarming surge in infections. Our results predict that at the current rate of vaccination, the new infection cases for COVID-19 in the United States will approach zero by August 2021. This model can be used for other regions and for future epidemics and pandemics.
Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature
Authors: Ishizuka Kiyonobu , Miura Kenichiro , Hashimoto Taeko , Kaneko Naoto , Harita Yutaka , Yabuuchi Tomoo , Hisano Masataka , Fujinaga Shuichiro , Omori Tae , Yamaguchi Yutaka , Hattori Motoshi 
Published: June 2021

AbstractDetermining the cause of focal segmental glomerulosclerosis (FSGS) has crucial implications for evaluating the risk of posttransplant recurrence. The degree of foot process effacement (FPE) on electron micrographs (EM) of native kidney biopsies can reportedly differentiate primary FSGS from secondary FSGS. However, no systematic evaluation of FPE in genetic FSGS has been performed. In this study, percentage of FPE and foot process width (FPW) in native kidney biopsies were analyzed in eight genetic FSGS patients and nine primary FSGS patients. All genetic FSGS patients showed segmental FPE up to 38% and FPW below 2000 nm, while all primary FSGS patients showed diffuse FPE above 88% and FPW above 3000 nm. We reviewed the literature which described the degree of FPE in genetic FSGS patients and identified 38 patients with a description of the degree of FPE. The degree of FPE in patients with mutations in the genes encoding proteins associated with slit diaphragm and cytoskeletal proteins was varied, while almost all patients with mutations in other FSGS genes showed segmental FPE. In conclusion, the present study suggests that the degree of FPE in native kidney biopsies may be useful for differentiating some genetic FSGS patients from primary FSGS patients.
Variability in waxy (Wx) allele, in-vitro starch digestibility, glycemic response and textural behaviour of popular Northern Himalayan rice varieties
Authors: Naseer Bazila , Naik H. R. , Hussain Syed Zameer , Shikari Asif Bashir , Noor Nowsheen 
Published: June 2021

AbstractEight commonly cultivated and consumed rice varieties of Northern Himalayan regions and a popular high amylose rice variety were characterized at Wx locus and evaluated for resistant starch (RS), in-vitro starch digestibility, predicted glycemic index (pGI), glycemic load (GL) and textural parameters. Cytosine and thymine repeats (CT)n at waxy locus (Wx) showed high association with apparent amylose content (AAC). Both pGI and GL varied substantially within the selected varieties. The pGI was relatively lower in high and intermediate amylose Indica varieties compared to low amylose Japonica ones. However, Koshikari despite being a low amylose variety showed relatively lower pGI and GL, due to its higher RS, dietary fiber, protein and fat content. It was thus presumed that in addition to AAC, RS and other grain components also affect the glycemic response. Inherent resistance to enzymatic hydrolysis was also found to be higher in firm textured and less sticky rice varieties. The genotypes—Lalat, Basmati-1509 and Koshikari, in view of their low to moderate pGI and relatively higher RS content, can be explored in future breeding programmes to develop rice varieties whose consumption will help to prevent hyper/hypo glycemic responses in Northern Himalayan regions, where daily staple diet is rice.
Independent influence of age on heart rate recovery after flywheel exercise in trained men and women
Authors: Zubac Damir , Goswami Nandu , Ivančev Vladimir , Valić Zoran , Šimunič Boštjan 
Published: June 2021

AbstractThe present study examined whether differences in the heart rate recovery following flywheel exercise cessation were associated with differences in maximal oxygen uptake ($${\dot{\text{V}}}$$

V
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O2 max.), age and sex in trained adults. Eleven men (age range 22–49 years, $${\dot{\text{V}}}$$

V
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O2 max. = 43.6 ± 7.6 mL kg min−1) and ten women (age range 20—53 years, $${\dot{\text{V}}}$$

V
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O2 max. = 38.0 ± 5.7 mL kg min−1) were randomly assigned to complete a squat-exercise on the flywheel ergometer set at three different moments of inertia, while their cardiovascular responses were continuously monitored. During the flywheel exercise the mean arterial pressure rose by ~ 35 to 40% (p = .001), and the increment was more robust in men than women. The cardiac index was two-fold greater across both sexes compared to the baseline (p = .001), while the rise in heart rate (~ 144 bpm) was more pronounced in women to compensate for their load-dependent stroke index decline (p = .001). The load-independent time-course changes in heart rate recovery markers were comparable between the sexes. When these indicators were pooled, a stepwise regression revealed age as the only relevant predictor of both fast and slow components of the heart rate recovery (~ 30% of the shared variance explained, p = .014). The present data suggest that the heart rate recovery declines with age, irrespective of sex, or well-preserved cardiorespiratory fitness in moderately-trained adults.
Elucidation of the relationship between sensory processing and white matter using diffusion tensor imaging tractography in young adults
Authors: Shiotsu Daichi , Jung Minyoung , Habata Kaie , Kamiya Taku , Omori Ichiro M. , Okazawa Hidehiko , Kosaka Hirotaka 
Published: June 2021

AbstractSensory processing and behaviors are altered during the development of connectivity between the sensory cortices and multiple brain regions in an experience-dependent manner. To reveal the relationship between sensory processing and brain white matter, we investigated the association between the Adolescent/Adult Sensory Profile (AASP) and neural connectivity in the white matter tracts of 84 healthy young adults using diffusion tensor imaging (DTI). We observed a positive relationship between AASP scores (i.e., sensory sensitivity, sensation avoiding, activity level)/subscores (i.e., sensory sensitivity–activity level, sensation avoiding–touch) and DTI parameters in the cingulum–cingulate gyrus bundle (CCG) and between AASP subscores (i.e., sensory sensitivity–auditory) and a diffusion parameter in the uncinate fasciculus (UNC). The diffusion parameters that correlated with AASP scores/subscores and AASP quadrant scores (i.e., sensory avoiding and sensitivity) were axonal diffusivity (AD) and mean diffusivity (MD) in the CCG and MD in the UNC. Moreover, the increased sensory avoiding and sensitivity scores represent the sensitization of sensory processing, and the level of diffusivity parameters indicates white matter microstructure variability, such as axons and myelin from diffusivity of water molecules. Thus, the present study suggests that the CCG and UNC are critical white matter microstructures for determining the level of sensory processing in young adults.
Isolation, purification and identification of biological compounds from Beauveria sp. and their evaluation as insecticidal effectiveness against Bemisia tabaci
Authors: An Ran , Ahmed Maqsood , Li Haiyan , Wang Yanbin , Zhang Aimin , Bi Yuhui , Yu Zhiguo 
Published: June 2021

AbstractBemisia tabaci is one of the most notorious agricultural pests in the world. A vicious circle among insect resistance, dose increased, environment and human body impaired as the overuse of synthetic pesticides are becoming increasingly evident. Entomopathogenic Beauveria sp. is known as an effective natural enemy to control B. tabaci. Therefore, this study aimed to purify and identify the biological compounds from Beauveria sp. LY2 via extensive chromatographic techniques, NMR and MS and evaluated for their insecticidal activities against B. tabaci via contact and feeding assay. The outcome identified that one new cerebroside, cerebroside F (1), nine known compounds, cerebroside B (2), bassiatin (3), methyl 1,4-dihydro-4-oxo-2-quinolinecarboxylate (4), cerevisterol (5), 9-hydroxycerevisterol (6), 6-dehydrocerevisterol (7), (22E,24R)-ergosta-8(14),22-diene-3β,5α,6β,7α-tetrol (8), melithasterol B (9) and ergosterol peroxide (10) were isolated. Among the known compounds, methyl 1,4-dihydro-4-oxo- 2-quinolinecarboxylate (4) was isolated from natural origin for the first time. It is demonstrable from the results that compounds 3, 4 and 7 strongly featured insecticidal activities against B. tabaci, being the LC50 value as 10.59, 19.05, 26.59 μg/mL respectively in contact as well as 11.42, 5.66, 5.65 μg/mL respectively in feeding experiment. Moreover, no adverse effect on plant growth/height or phytotoxicity was observed on pepper, cucumber, tomato and cotton. The data from the current study has provided the foundation for the use of newly purified compounds against Bemisia tabaci as an alternative to synthetic chemical compounds.
Characterization of the G protein-coupled receptor family SREB across fish evolution
Authors: Breton Timothy S. , Sampson William G. B. , Clifford Benjamin , Phaneuf Anyssa M. , Smidt Ilze , True Tamera , Wilcox Andrew R. , Lipscomb Taylor , Murray Casey , DiMaggio Matthew A. 
Published: June 2021

AbstractThe SREB (Super-conserved Receptors Expressed in Brain) family of G protein-coupled receptors is highly conserved across vertebrates and consists of three members: SREB1 (orphan receptor GPR27), SREB2 (GPR85), and SREB3 (GPR173). Ligands for these receptors are largely unknown or only recently identified, and functions for all three are still beginning to be understood, including roles in glucose homeostasis, neurogenesis, and hypothalamic control of reproduction. In addition to the brain, all three are expressed in gonads, but relatively few studies have focused on this, especially in non-mammalian models or in an integrated approach across the entire receptor family. The purpose of this study was to more fully characterize sreb genes in fish, using comparative genomics and gonadal expression analyses in five diverse ray-finned (Actinopterygii) species across evolution. Several unique characteristics were identified in fish, including: (1) a novel, fourth euteleost-specific gene (sreb3b or gpr173b) that likely emerged from a copy of sreb3 in a separate event after the teleost whole genome duplication, (2) sreb3a gene loss in Order Cyprinodontiformes, and (3) expression differences between a gar species and teleosts. Overall, gonadal patterns suggested an important role for all sreb genes in teleost testicular development, while gar were characterized by greater ovarian expression that may reflect similar roles to mammals. The novel sreb3b gene was also characterized by several unique features, including divergent but highly conserved amino acid positions, and elevated brain expression in puffer (Dichotomyctere nigroviridis) that more closely matched sreb2, not sreb3a. These results demonstrate that SREBs may differ among vertebrates in genomic structure and function, and more research is needed to better understand these roles in fish.
Nicotine delivery and relief of craving after consumption of European JUUL e-cigarettes prior and after pod modification
Authors: Mallock Nadja , Rabenstein Andrea , Gernun Solveig , Laux Peter , Hutzler Christoph , Karch Susanne , Koller Gabriele , Henkler-Stephani Frank , Parr Maria Kristina , Pogarell Oliver , Luch Andreas , Rüther Tobias 
Published: June 2021

AbstractThe emergence of e-cigarettes on the consumer market led to a tremendous rise in e-cigarette consumption among adolescents in the United States. The success of JUUL and other pod systems was linked to its high nicotine delivery capacity. In compliance with the European Tobacco Product directive, liquid nicotine contents in the European JUUL variants are limited to 20 mg/mL or below. A short time after launching the initial version in Europe, JUUL pods have been modified in terms of the wick material used. This modification has been demonstrated previously to lead to an elevated aerosol generation, consequently, to a larger amount of nicotine per puff generated. The present study was designed to assess whether the mentioned differences between the “initial” and “modified” JUUL versions may cause a significant difference during consumption, and how nicotine delivery compares with tobacco cigarettes. In this single-center three-arm study, nicotine pharmacokinetics and influence on urge to smoke/vape were compared for tobacco cigarettes, the “initial” version of the European JUUL, and the “modified” version of the European JUUL. Participants, 15 active smokers and 17 active e-cigarette users, were instructed to consume their study product according to a pre-directed puffing protocol. Venous blood was sampled for nicotine analysis to cover the acute phase and the first 30 min after starting. Nicotine delivery and the reduction of urge to smoke/vape upon usage of both European JUUL variants were lower in comparison to tobacco cigarettes. This suggests a lower addictive potential. Modification of the pod design did not result in significant differences at the first ten puffs, as confirmed by a vaping machine experiment. Apparently, the limitations by the initially used wick material only come into effect after longer usage time.
Spin glass behavior and magnetic boson peak in a structural glass of a magnetic ionic liquid
Authors: Kofu Maiko , Watanuki Ryuta , Sakakibara Toshiro , Ohira-Kawamura Seiko , Nakajima Kenji , Matsuura Masato , Ueki Takeshi , Akutsu Kazuhiro , Yamamuro Osamu 
Published: June 2021

AbstractGlassy magnetic behavior has been observed in a wide range of crystalline magnetic materials called spin glass. Here, we report spin glass behavior in a structural glass of a magnetic ionic liquid, C4mimFeCl4. Magnetization measurements demonstrate that an antiferromagnetic ordering occurs at TN = 2.3 K in the crystalline state, while a spin glass transition occurs at TSG = 0.4 K in the structural glass state. In addition, localized magnetic excitations were found in the spin glass state by inelastic neutron scattering, in contrast to spin-wave excitations in the ordered phase of the crystalline sample. The localized excitation was scaled by the Bose population factor below TSG and gradually disappeared above TSG. This feature is highly reminiscent of boson peaks commonly observed in structural glasses. We suggest the “magnetic” boson peak to be one of the inherent dynamics of a spin glass state.
Osmotically balanced, large unilamellar liposomes that enable sustained bupivacaine release for prolonged pain relief in in vivo rat models
Authors: Yoo Hyebin , Park Jun Seok , Oh Seung Soo , Kang Hyun 
Published: June 2021

AbstractTo efficiently prolong analgesic effects, we developed osmotically balanced, large unilamellar liposomes (~ 6 μm in diameter) in which highly concentrated bupivacaine (up to 30 mg/mL) was encapsulated, and their sustained bupivacaine release was highly effective in relieving postoperative pain over 24 h in a rat model. Our reverse-phase evaporation method based on non-toxic alcohol, ethanol, enabled simple and cost-effective production of bupivacaine-loaded liposomes, of which osmotic pressure was readily balanced to improve the structural stability of the enlarged unilamellar liposomes along with extension of their shelf life (> a month). The in vitro release profile verified that the release duration of the bupivacaine-loaded liposomes extended up to 6 days. For the in vivo study, male Sprague–Dawley rats were used for the incisional pain model, simulating postoperative pain, and the mechanical withdrawal threshold (MWT) was measured using a von Frey filament. Compared to the control group that received intraplantar administration of normal saline, the group of liposomal bupivacaine showed that the initially increased MWT gradually decreased up to 24 h, and importantly, the analgesic effect of the liposomal bupivacaine was maintained 6 times longer than that of bupivacaine only, proving the potential of effective long-acting anesthetics.
Parental socioeconomic status and adolescent health in Japan
Authors: Okamoto Shohei 
Published: June 2021

AbstractThere is no consensus on which parental socioeconomic indicators should be used to define adolescents’ socioeconomic status (SES). Utilising the data for 3154 parent-adolescent pairs obtained from the sample of the Survey of Lifestyle Value of Parents and Children 2011 conducted by the Cabinet Office in Japan, the associations between adolescent’s subjective economic status, parental SES (i.e. education, occupation, and household income), and child health-related outcomes (i.e. self-rated health, dietary and oral health behaviours) were analysed using multilevel mixed-effects ordered logistic regression to investigate heterogeneity in these relationships across SES indicators and health outcome measures. Results demonstrated that income was the strongest predictor of adolescent health outcomes, suggesting that adolescents in the middle- or high-income groups tended to report better health status compared to the low-income group, have a higher frequency of having breakfast, and more likely to regularly brush their teeth by 24% (OR 1.24, 95% CI [1.06–1.46]) to 66% (OR 1.66, 95% CI [1.30–2.12]). Parental education was also related to child health-related behaviours, with higher levels of habitual healthy behaviours being observed in the middle- and high-education groups than in the low-education group by 15% (OR 1.15, 95% CI [1.01–1.32]) to 63% (OR 1.63, 95% CI [1.31–2.03]). Future studies regarding health disparities among children/adolescents should carefully choose an SES indicator, taking multiple pathways between each SES indicator and health/health behaviours into consideration.
Accessory proteins of the RAS-MAPK pathway: moving from the side line to the front line
Authors: Pudewell Silke , Wittich Christoph , Kazemein Jasemi Neda S. , Bazgir Farhad , Ahmadian Mohammad R. 
Published: June 2021

AbstractHealth and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its spatiotemporal features is afflicted with major conceptual shortcomings. Here we consider how the compilation of a vast array of accessory proteins may resolve some parts of the puzzles in this field, as they safeguard the strength, efficiency and specificity of signal transduction. Targeting such modulators, rather than the constituent components of the RTK-RAS-MAPK signalling cascade may attenuate rather than inhibit disease-relevant signalling pathways.
Why reducing the cosmic sound horizon alone can not fully resolve the Hubble tension
Authors: Jedamzik Karsten , Pogosian Levon , Zhao Gong-Bo 
Published: June 2021

AbstractThe mismatch between the locally measured expansion rate of the universe and the one inferred from the cosmic microwave background measurements by Planck in the context of the standard ΛCDM, known as the Hubble tension, has become one of the most pressing problems in cosmology. A large number of amendments to the ΛCDM model have been proposed in order to solve this tension. Many of them introduce new physics, such as early dark energy, modifications of the standard model neutrino sector, extra radiation, primordial magnetic fields or varying fundamental constants, with the aim of reducing the sound horizon at recombination r⋆. We demonstrate here that any model which only reduces r⋆ can never fully resolve the Hubble tension while remaining consistent with other cosmological datasets. We show explicitly that models which achieve a higher Hubble constant with lower values of matter density Ωmh2 run into tension with the observations of baryon acoustic oscillations, while models with larger Ωmh2 develop tension with galaxy weak lensing data.
Passive wireless respiratory sensor
Authors: Feng Bin , Zhao Kai , Su Qiucheng , Yu Zhentao , Jin Hao 
Published: June 2021

AbstractMonitoring respiratory characteristics is an important method to monitor sleep respiratory diseases such as obstructive sleep apnea syndrome (OSAS). In this letter, a passive wireless respiratory sensor is developed, which is based on a surface acoustic wave (SAW) microsensor using graphene oxide as a sensitive layer. The developed sensor is placed on the upper lip below the nose, which monitors human's breathing by detecting the humidity changes while inhale and exhale. To meet the fast response requirement of human respiratory, the effect of the thicknesses of graphene oxide (GO) films is investigated. Results show that the response and recovery time of the sensor can achieve 0.4 and 1.4 s, respectively, with the optimized 70‐nm thickness of GO. The respiratory rate that the sensing system can measure is greater than 33 breaths per minute, outcompeting the average number of breaths per minute from an adult (i.e. 16–20 breaths per minute). The new sensor proposed here paves the way for the fabrication of high‐performance and low‐cost respiratory sensors in human breathing monitoring in real life.
Atomic diffusion and mixing in old stars
Authors: Gavel Alvin , Gruyters Pieter , Heiter Ulrike , Korn Andreas J. , Nordlander Thomas , Scheutwinkel Kilian H. , Richard Olivier A. 
Published: June 2021

Aims.We attempt to constrain the efficiency of additional transport or mixing processes that reduce the effect of atomic diffusion in stellar atmospheres.Methods.We apply spectral synthesis methods to spectra observed with the GIRAFFE spectrograph on the VLT to estimate abundances of Mg, Ti, Fe, and Ba in stars in the metal-poor globular cluster M 30. To the abundances we fit trends of abundances predicted by stellar evolution models assuming different efficiencies of additional transport or mixing processes. The fitting procedure attempts to take into account the effects of parameter-dependent systematic errors in the derived abundances.Results.We find that the parameterT0, which describes the efficiency of additional transport or mixing processes, can almost certainly be constrained to the narrow range log10(T0/[K]) between 6.09 and 6.2. This corresponds to decreased abundances for stars at the main sequence turn-off point compared to the red giant branch by 0.2 dex for Mg, 0.1 dex for Fe, and 0.07 dex for Ti. We also find that while our estimates do have non-negligible systematic errors stemming from the continuum placement and the assumed microturbulence, our method can take them into account.Conclusions.Our results partly amend the results of an earlier paper in this article series, that tentatively used a value of log10(T0/[K]) = 6.0 when modelling the Spite plateau of lithium. To more easily distinguish physical effects from systematic errors, we recommend that studies of this kind focus on elements for which the expected surface abundances as functions of effective temperature have a distinct structure and cover a wide range.