bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using strong lensing to understand the microJy radio emission in two radio quiet quasars at redshift 1.7
Authors: Hartley P , Jackson N , Badole S , McKean J P , Sluse D , Vives-Arias H 
Published: October 2021

ABSTRACT
The radio quasar luminosity function exhibits an upturn around $L_{6\rm \:GHz}=10^{23}$ W Hz−1 that is well-modelled by a star-forming host galaxy population. This distribution leads some authors to cite star formation as the main radio emission mechanism in so-called radio-quiet quasars (RQQs). Understanding the origin of RQQ radio emission is crucial for our understanding of quasar feedback mechanisms – responsible for the regulation of star formation in the host galaxy – and for understanding galaxy evolution as a whole. By observing RQQs that have been magnified by strong gravitational lensing, we have direct access to the RQQ population out to cosmic noon, where evidence for twin mini-jets has recently been found in a sub-$\mu$Jy RQQ. Here we present radio observations of two lensed RQQs using the VLA at 5 GHz, the latest objects to be observed in a sample of quadruply-imaged RQQs above −30°. In SDSS J1004+4112 we find strong evidence for AGN-related radio emission in the variability of the source. In PG 1115+080 we find tentative evidence for AGN-related emission, determined by comparing the radio luminosity with modelled dust components. If confirmed in the case of PG 1115+080, which lies on the radio–FIR correlation, the result would reinforce the need for caution when applying the correlation to rule out jet activity and when assuming no AGN heating of FIR-emitting dust when calculating star formation rates. Our programme so far has shown that the two of the faintest radio sources ever imaged show strong evidence for AGN-dominated radio emission.
Using the EAGLE simulations to elucidate the origin of disc surface brightness profile breaks as a function of mass and environment
Authors: Pfeffer Joel L , Bekki Kenji , Forbes Duncan A , Couch Warrick J , Koribalski Bärbel S 
Published: October 2021

ABSTRACT
We analyse the surface brightness profiles of disc-type galaxies in the Evolution and Assembly of GaLaxies and their Environment (EAGLE) simulations in order to investigate the effects of galaxy mass and environment on galaxy profile types. Following observational works, we classify the simulated galaxies by their disc surface brightness profiles into single exponential (Type I), truncated (Type II), and antitruncated (Type III) profiles. In agreement with previous observation and theoretical work, we find that Type II discs result from truncated star-forming discs that drive radial gradients in the stellar populations. In contrast, Type III profiles result from galaxy mergers, extended star-forming discs or the late formation of a steeper, inner disc. We find that the EAGLE simulations qualitatively reproduce the observed trends found between profile type frequency and galaxy mass, morphology and environment, such as the fraction of Type III galaxies increasing with galaxy mass, and the fraction of Type II galaxies increasing with Hubble type. We investigate the lower incidence of Type II galaxies in galaxy clusters, finding, in a striking similarity to observed galaxies, that almost no S0-like galaxies in clusters have Type II profiles. Similarly, the fraction of Type II profiles for disc-dominated galaxies in clusters is significantly decreased relative to field galaxies. This difference between field and cluster galaxies is driven by star formation quenching. Following the cessation of star formation upon entering a galaxy cluster, the young stellar populations of Type II galaxies simply fade, leaving behind Type I galaxies.
The Galactic metallicity gradient shown by open clusters in the light of radial migration
Authors: Netopil Martin , Oralhan İnci Akkaya , Çakmak Hikmet , Michel Raúl , Karataş Yüksel 
Published: October 2021

ABSTRACT
During the last years and decades, several individual studies and large-scale spectroscopic surveys significantly improved our knowledge of the Galactic metallicity distribution based on open clusters. The availability of Gaia data provided a further step forward in our knowledge. However, still some open issues remain, for example, the influence of radial migration on the interpretation of the observed gradients. We used spectroscopic metallicities from individual studies and from the APOGEE survey to compile a sample of 136 open clusters, with a membership verification based on Gaia DR2. Additionally, we present photometric metallicity estimates of 14 open clusters in a somewhat outer Galactic region. Eight age groups allow us to study the evolution of the metallicity gradient in detail, showing within the errors an almost constant gradient of about −0.06 dex kpc−1. Furthermore, using the derived gradients and an analysis of the individual objects, we estimate a mean migration rate of 1 kpc Gyr−1 for objects up to about 2 Gyr. Here, the change of the guiding radius is clearly the main contributor. For older and dynamically hotter objects up to 6 Gyr we infer a lower migration rate of up to 0.5 kpc Gyr−1. The influence of epicyclic excursions increases with age and contributes already about 1 kpc to the total migration distance after 6 Gyr. A comparison of our results with available models shows good agreement. However, there is still a lack of a suitable coverage of older objects, future studies are still needed to provide a better sampling in this respect.
Boundary layers of accretion discs: Discovery of vortex-driven modes and other waves
Authors: Coleman Matthew S B , Rafikov Roman R , Philippov Alexander A 
Published: October 2021

ABSTRACT
Disc accretion on to weakly magnetized objects possessing a material surface must proceed via the so-called boundary layer (BL) – a region at the inner edge of the disc, in which the velocity of accreting material abruptly decreases from its Keplerian value. Supersonic shear arising in the BL is known to be conducive to excitation of acoustic waves that propagate into both the accretor and the disc, enabling angular momentum and mass transport across the BL. We carry out a numerical exploration of different wave modes that operate near the BL, focusing on their morphological characteristics in the innermost parts of accretion disc. Using a large suite of simulations covering a broad range of Mach numbers (of the supersonic shear flow in the BL), we provide accurate characterization of the different types of modes, verifying their properties against analytical results, when available. We discover new types of modes, in particular, global spiral density waves launched by vortices forming in the disc near the BL as a result of the Rossby wave instability; this instability is triggered by the vortensity production in that region caused by the non-linear damping of acoustic waves. Azimuthal wavenumbers of the dominant modes that we observe appear to increase monotonically with the Mach number of the runs, but a particular mix of modes found in a simulation is mildly stochastic. Our results provide a basis for better understanding of the angular momentum and mass transport across the BL as well as the emission variability in accreting objects.
Energy signature of ton TNT-class impacts: analysis of the 2018 December 22 fireball over Western Pyrenees
Authors: Anghel S , Drolshagen E , Ott T , Birlan M , Colas F , Nedelcu D A , Koschny D , Zanda B , Bouley S , Jeanne S , Malgoyre A , Blanpain C , Gattacceca J , Jorda L , Lecubin J , Rault J L , Vaubaillon J , Vernazza P , Hueso R , Peña-Asensio E , Ribas S J , Rimola A , Sánchez-Lavega A , Tapia M , Trigo-Rodriguez J M , Cauhape P , Davadan C , Dupouy P , Herpin M , Rousseu D , Tregon B 
Published: October 2021

ABSTRACT
The increase in detector sensitivity and availability in the past three decades has allowed us to derive knowledge of the meteoroid flux and impact energy into the Earth’s atmosphere. We present the multi-instrument detected 2018 December 22 fireball over Western Pyrenees, and compare several techniques aiming to obtain a reliable method to be used when measuring impacts of similar scale. From trajectory data alone, we found a bulk density of 3.5 g cm−3 to be the most likely value for the Pyrenean meteoroid. This allowed to further constrain the dynamic mass, which translated into a kinetic energy of 1 ton TNT (4.184 × 109 J). For the second energy derivation, via the fireball’s corrected optical radiation, we obtained a more accurate empirical relation measuring well-studied bolides. The result approximates to 1.1 ton TNT, which is notably close to the nominal dynamic result, and agrees with the lower margin of the seismic-based energy estimation, yet way lower than the infrasound estimate. Based on the relation derived in this study, we consider the nominal estimate from both the dynamic and photometric methods to be the most accurate value of deposited energy (1 ton TNT). We show that the combination of these two methods can be used to infer the meteoroid density. Among the methods presented in this paper, we found that the optical energy is the most reliable predictor of impact energy near the ton TNT-scale.
Candidate isolated neutron stars in the 4XMM-DR10 catalogue of X-ray sources
Authors: Rigoselli Michela , Mereghetti Sandro , Tresoldi Caterina 
Published: October 2021

ABSTRACT
Most isolated neutron stars have been discovered thanks to the detection of their pulsed non-thermal emission, at wavelengths spanning from radio to gamma-rays. However, if the beamed non-thermal radiation does not intercept our line of sight or it is too faint or absent, isolated neutron stars can also be detected through their thermal emission, which peaks in the soft X-ray band and is emitted nearly isotropically. In the past 30 yr, several thermally emitting isolated neutron stars have been discovered thanks to X-ray all-sky surveys, observations targeted at the centre of supernova remnants, or as serendipitous X-ray sources. Distinctive properties of these relatively rare X-ray sources are very soft spectra and high ratios of X-ray to optical flux. The recently released 4XMM-DR10 catalogue contains more than half a million X-ray sources detected with the XMM–Newton telescope in the 0.2–10 keV range in observations carried out from 2000 to 2019. Based on a study of the spectral properties of these sources and on cross-correlations with catalogues of possible counterparts, we have carried out a search of isolated neutron stars, finding four potential candidates. The spectral and long-term variability analysis of these candidates, using Chandra and Swift-XRT data, allowed us to point out the most interesting sources deserving further multiwavelength investigations.
Stark broadening of B I spectral lines
Authors: Dimitrijević Milan S , Christova Magdalena D , Sahal-Bréchot Sylvie 
Published: October 2021

ABSTRACT
We calculated widths and shifts due to collisions with electrons, protons, and He II ions for 66 multiplets of neutral boron, using the semiclassical perturbation theory. The range of temperatures is from 2500 to 50 000 K and electron density values are within the range 1011–1019 cm−3. The obtained Stark broadening parameters have been compared to other theoretical and experimental results.
GreeNC 2.0: a comprehensive database of plant long non-coding RNAs
Authors: Di Marsico Marco , Paytuvi Gallart Andreu , Sanseverino Walter , Aiese Cigliano Riccardo 
Published: October 2021

AbstractThe Green Non-Coding Database (GreeNC) is one of the reference databases for the study of plant long non-coding RNAs (lncRNAs). Here we present our most recent update where 16 species have been updated, while 78 species have been added, resulting in the annotation of more than 495 000 lncRNAs. Moreover, sequence clustering was applied providing information about sequence conservation and gene families. The current version of the database is available at: http://greenc.sequentiabiotech.com/wiki2/Main_Page.
Nanomechanics of negatively supercoiled diaminopurine-substituted DNA
Authors: Salerno Domenico , Marrano Claudia Adriana , Cassina Valeria , Cristofalo Matteo , Shao Qing , Finzi Laura , Mantegazza Francesco , Dunlap David 
Published: October 2021

Abstract
Single molecule experiments have demonstrated a progressive transition from a B- to an L-form helix as DNA is gently stretched and progressively unwound. The particular sequence of a DNA segment defines both base stacking and hydrogen bonding that affect the partitioning and conformations of the two phases. Naturally or artificially modified bases alter H-bonds and base stacking and DNA with diaminopurine (DAP) replacing adenine was synthesized to produce linear fragments with triply hydrogen-bonded DAP:T base pairs. Both unmodified and DAP-substituted DNA transitioned from a B- to an L-helix under physiological conditions of mild tension and unwinding. This transition avoids writhing and the ease of this transition may prevent cumbersome topological rearrangements in genomic DNA that would require topoisomerase activity to resolve. L-DNA displayed about tenfold lower persistence length than B-DNA. However, left-handed DAP-substituted DNA was twice as stiff as unmodified L-DNA. Unmodified DNA and DAP-substituted DNA have very distinct mechanical characteristics at physiological levels of negative supercoiling and tension.
A post-transcriptional regulon controlled by TtpA, the single tristetraprolin family member expressed in Dictyostelium discoideum
Authors: Bai Wenli , Wells Melissa L , Lai Wi S , Hicks Stephanie N , Burkholder Adam B , Perera Lalith , Kimmel Alan R , Blackshear Perry J 
Published: October 2021

Abstract
Post-transcriptional processes mediated by mRNA binding proteins represent important control points in gene expression. In eukaryotes, mRNAs containing specific AU-rich motifs are regulated by binding of tristetraprolin (TTP) family tandem zinc finger proteins, which promote mRNA deadenylation and decay, partly through interaction of a conserved C-terminal CNOT1 binding (CNB) domain with CCR4–NOT protein complexes. The social ameba Dictyostelium discoideum shared a common ancestor with humans more than a billion years ago, and expresses only one TTP family protein, TtpA, in contrast to three members expressed in humans. Evaluation of ttpA null-mutants identified six transcripts that were consistently upregulated compared to WT during growth and early development. The 3′-untranslated regions (3′-UTRs) of all six ‘TtpA-target’ mRNAs contained multiple TTP binding motifs (UUAUUUAUU), and one 3′-UTR conferred TtpA post-transcriptional stability regulation to a heterologous mRNA that was abrogated by mutations in the core TTP-binding motifs. All six target transcripts were upregulated to similar extents in a C-terminal truncation mutant, in contrast to less severe effects of analogous mutants in mice. All six target transcripts encoded probable membrane proteins. In Dictyostelium, TtpA may control an ‘RNA regulon’, where a single RNA binding protein, TtpA, post-transcriptionally co-regulates expression of several functionally related proteins.
ReMap 2022: a database of Human, Mouse, Drosophila and Arabidopsis regulatory regions from an integrative analysis of DNA-binding sequencing experiments
Authors: Hammal Fayrouz , de Langen Pierre , Bergon Aurélie , Lopez Fabrice , Ballester Benoit 
Published: October 2021

Abstract
ReMap (https://remap.univ-amu.fr) aims to provide manually curated, high-quality catalogs of regulatory regions resulting from a large-scale integrative analysis of DNA-binding experiments in Human, Mouse, Fly and Arabidopsis thaliana for hundreds of transcription factors and regulators. In this 2022 update, we have uniformly processed &gt;11 000 DNA-binding sequencing datasets from public sources across four species. The updated Human regulatory atlas includes 8103 datasets covering a total of 1210 transcriptional regulators (TRs) with a catalog of 182 million (M) peaks, while the updated Arabidopsis atlas reaches 4.8M peaks, 423 TRs across 694 datasets. Also, this ReMap release is enriched by two new regulatory catalogs for Mus musculus and Drosophila melanogaster. First, the Mouse regulatory catalog consists of 123M peaks across 648 TRs as a result of the integration and validation of 5503 ChIP-seq datasets. Second, the Drosophila melanogaster catalog contains 16.6M peaks across 550 TRs from the integration of 1205 datasets. The four regulatory catalogs are browsable through track hubs at UCSC, Ensembl and NCBI genome browsers. Finally, ReMap 2022 comes with a new Cis Regulatory Module identification method, improved quality controls, faster search results, and better user experience with an interactive tour and video tutorials on browsing and filtering ReMap catalogs.
Application and Clinical Value of Definitive Drug Monitoring in Pain Management and Addiction Medicine
Authors: Rosano Thomas G , Wood Michelle , Hooten W Michael , Rumberger John M , Fudin Jeffrey , Argoff Charles E 
Published: October 2021

Abstract

Objective
To assess routine application and clinical value of definitive urine drug monitoring (UDM) for drug detection, inconsistent drug use, and prescription adherence, along with a comparison to immunoassay screening (IAS).

Methods
Direct-to-definitive UDM performance was analyzed retrospectively in 5000 patient specimens. Drug findings, medication inconsistencies, and detection sensitivity were assessed, and definitive UDM versus IAS monitoring was studied.

Results
Definitive testing resulted in 18,793 drug findings with 28,403 positive drug and metabolite tests. Definitive testing expanded monitoring with 11,396 drug findings that would not be tested by IAS. The opioids accounted for the highest frequency of inconsistent positive drug-use findings, at 12%. Conversely, inconsistent negative drug findings, used as an index of prescription non-adherence, were determined in 1,751 of 15,409 monitored medications and included a high frequency of antidepressants and antipsychotics inconsistencies. Direct comparison of definitive UDM and IAS showed false-positives by IAS as well as a high rate of false-negatives that would be missed using current confirmation protocols.

Conclusions
Results from routine application of direct-to-definitive UDM demonstrate the clinical value of drug-use identification and the objective evaluation of inconsistencies in drug misuse and medication adherence in pain management and addiction medicine practice. Without conversion to direct-to-definitive UDM, continuing use of IAS will limit the scope of drugs being tested, will result in an indeterminate rate of false negatives and will require confirmation testing to eliminate the reporting of false-positive IAS tests. The findings in this study provide evidence-based support for recommended use of a direct-to-definitive drug testing protocol.
Racial Disparities in ICU Outcomes: A Systematic Review*
Authors: McGowan Samuel K. , Sarigiannis Kalli A. , Fox Samuel C. , Gottlieb Michael A. , Chen Elaine 
Published: October 2021

Objectives:
Racial disparities in the United States healthcare system are well described across a variety of clinical settings. The ICU is a clinical environment with a higher acuity and mortality rate, potentially compounding the impact of disparities on patients. We sought to systematically analyze the literature to assess the prevalence of racial disparities in the ICU.

Data Sources:
We conducted a comprehensive search of PubMed/MEDLINE, Scopus, CINAHL, and the Cochrane Library.

Study Selection:
We identified articles that evaluated racial differences on outcomes among ICU patients in the United States. Two authors independently screened and selected articles for inclusion.

Data Extraction:
We dual-extracted study characteristics and outcomes that assessed for disparities in care (e.g., in-hospital mortality, ICU length of stay). Studies were assessed for bias using the Newcastle-Ottawa Scale.

Data Synthesis:
Of 1,325 articles screened, 25 articles were included (n = 751,796 patients). Studies demonstrated race-based differences in outcomes, including higher mortality rates for Black patients when compared with White patients. However, when controlling for confounding variables, such as severity of illness and hospital type, mortality differences based on race were no longer observed. Additionally, results revealed that Black patients experienced greater financial impacts during an ICU admission, were less likely to receive early tracheostomy, and were less likely to receive timely antibiotics than White patients. Many studies also observed differences in patients’ end-of-life care, including lower rates on the quality of dying, less advanced care planning, and higher intensity of interventions at the end of life for Black patients.

Conclusions:
This systematic review found significant differences in the care and outcomes among ICU patients of different races. Mortality differences were largely explained by accompanying demographic and patient factors, highlighting the effect of structural inequalities on racial differences in mortality in the ICU. This systematic review provides evidence that structural inequalities in care persist in the ICU, which contribute to racial disparities in care. Future research should evaluate interventions to address inequality in the ICU.
Validation of the InBody BPBIO210 manual auscultatory hybrid device for professional office use in a general population according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization Universal Standard
Authors: Ntineri Angeliki , Menti Ariadni , Kyriakoulis Konstantinos G. , Bountzona Ioanna , Prapa Sofia , Kollias Anastasios , Stergiou George S. 
Published: October 2021

Objective
To evaluate the accuracy of the InBody BPBIO210 manual auscultatory mercury-free hybrid blood pressure (BP) measuring device for professional office use in a general population according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO) Universal Standard (ISO 81060-2:2018).

Methods
Subjects were recruited to fulfil the age, sex, BP and cuff distribution criteria of the AAMI/ESH/ISO Universal Standard in a general population using the same arm sequential BP measurement method. Two cuffs of the test device were used for arm circumference 22–32 (medium) and 32–42 cm (large).

Results
A total of 94 subjects were recruited and 86 were analysed (mean age 53.7 ± 18.4 [SD] years, 50 men, arm circumference 32.5 ± 4.8 cm, range 22–42 cm). For the validation Criterion 1, the mean ± SD of the differences between the test device and reference BP readings was −1.0 ± 4.1/−0.7 ± 2.5 mmHg (systolic/diastolic). For Criterion 2, the SD of the averaged BP differences between the test device and reference BP per subject was 2.65/1.59 mmHg (systolic/diastolic).

Conclusions
The InBody BPBIO210 manual auscultatory hybrid device for professional office BP measurement fulfilled all the requirements of the AAMI/ESH/ISO Universal Standard (ISO 81060-2:2018) in a general population and can be recommended for clinical use.