bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Push-pull Central-lever Mechanism Reduces Peak Forces and Energy-cost Compared to Hand-rim Wheelchair Propulsion During a Controlled Lab-based Experiment
Authors: Rütte Thomas A le , Trigo Fransisca , Bessems Luca , Woude Lucas HV van der , Vegter Riemer JK 
Published: September 2021

Abstract
Background: Hand-rim wheelchair propulsion is straining and mechanically inefficient, often leading to upper limb complaints. Previous push-pull lever propulsion mechanisms have shown to perform better or equal in efficiency and physiological strain. Propulsion biomechanics have not been evaluated thus far. A novel push-pull central-lever propulsion mechanism is compared to conventional hand-rim wheelchair propulsion, using both physiological and biomechanical outcomes under low-intensity steady-state conditions on a motor driven treadmill. Methods: In this 5-day (distributed over a maximum of 21 days) between-group experiment, 30 able-bodied novices performed 60 minutes (5x3x4 min) of practice in either the push-pull central lever wheelchair (n=15) or the hand-rim wheelchair (n=15). At the first and final sessions cardiopulmonary strain, propulsion kinematics and force production were determined in both instrumented propulsion mechanisms. Repeated measures ANOVA evaluated between (propulsion mechanism type), within (over practice) and interaction effects. Results: Over practice, both groups significantly improved on all outcome measures. After practice the peak forces during the push and pull phase of lever propulsion were considerably lower compared to those in the handrim push phase (42±10 & 46±10 vs 63±21 N). Concomitantly, energy expenditure was found to be lower as well (263±45 vs 298±59 W), on the other hand gross mechanical efficiency (6.4±1.5 vs 5.9±1.3 %), heart-rate (97±10 vs 98±10 bpm) and perceived exertion (9±2 vs 10±1) were not significantly different between modes.Conclusion: The current study shows the potential benefits of the newly designed push-pull central-lever propulsion mechanism over regular hand rim wheelchair propulsion. The much lower forces and energy expenditure might help to reduce the strain on the upper extremities and thus prevent the development of overuse injury. This proof of concept in a controlled laboratory experiment warrants continued experimental research in wheelchair-users during daily life.
3-HAA Metabolic Pathway Regulates HCC Growth
Authors: Shi Zhaopeng , Gan Guifang , Gao Xianfu , Chen Fuxiang , Mi Jun 
Published: September 2021

Abstract
Background

Kynurenine, a metabolite of tryptophan, promotes immune tolerance in development and tumor evasion by binding to the aryl hydrocarbon receptor (AHR). However, the kynurenine catabolic enzyme IDO1 inhibitors fail in clinical trials.
Methods

The LC-MS/MS and GC-MS/MS were performed to measure the concentration of tryptophan metabolites. The PCX model, PDX model, and transposon liver cancer models were used to evaluate the effects of 3-HAA, DUSP6, and YY1 on HCC tumor formation and/or tumor growth.
Results

3-hydroxyanthranilic acid (3-HAA) induced HCC apoptosis and reduced xenografted tumor growth, the survival of the transposon HCC mice, and synergized with IDO1 inhibitor on HCC growth in vivo. Overexpression of 3-HAA synthesis enzyme KMO suppressed tumor formation and tumor growth by increasing endogenous 3-HAA while adding exogenous 3-HAA also inhibited tumor growth. Notably, 3-HAA was lower in tumor cells due to the downregulation of its synthetic enzyme KMO/KYNU and/or upregulation of its catalytic enzyme HAAO. The mechanistic investigation demonstrated that 3-HAA induced dual-specificity phosphatase 6 (DUSP6) transcription. DUSP6 overexpression induced apoptosis of hepatocellular carcinoma (HCC) cells and suppressed the HCC growth in vitro and in vivo. DUSP6 knockdown abolished 3-HAA-induced apoptosis and restores tumor growth.
Conclusions

These findings demonstrate that 3-HAA metabolic pathway regulates HCC cell growth, suggesting it is a promising therapeutic candidate for HCC.
Evaluation of Cardiac Functions By Speckle Tracking Echocardiography in Type 2 Diabetes Mellitus With Hyperlipidemia
Authors: Dong Zhizhi , Zhou Jun , Chen Yue , Liu Zulin , Shi Douzi , Zhou Chang , Liu Rong 
Published: September 2021

Abstract
Background

To investigate the value of two-dimensional speckle tracking echocardiography (2D-STE) in evaluating cardiac functions in type 2 diabetes mellitus (T2DM) with hyperlipidemia.
Methods

Sixty T2DM patients with normal left ventricular ejection fraction (LVEF) and poorly-controlled blood glucose were selected. Among these, thirty had hyperlipidemia. Thirty age- and gender-matched healthy individuals were recruited as the normal control group. Longitudinal strain of left ventricular segments, left ventricular global longitudinal strain (LV GLS), left atrial global longitudinal strain (LA GLS), right ventricular global longitudinal strain (RV GLS) and right atrial global longitudinal strain (RA GLS) were measured by 2D-STE.
Results

(1) Compared with the normal control group, LV GLS in T2DM group and T2DM with hyperlipidemia group decreased (P < 0.05), but there was no significant difference of LV GLS between T2DM group and T2DM with hyperlipidemia group (P > 0.05). Compared with the normal control group and T2DM group, longitudinal strain of middle segment of LV in T2DM with hyperlipidemia group decreased (P < 0.05). (2) There was a significant difference in LA GLS among the three groups. LA GLS of T2DM with hyperlipidemia group was lower compared with the normal control and T2DM group (P < 0.05). (3) Compared with the normal control group, RV GLS in T2DM group and T2DM with hyperlipidemia group was lower (P < 0.05), but there was no significant difference of RV GLS between T2DM group and T2DM with hyperlipidemia group (P > 0.05). RA GLS in T2DM with hyperlipidemia group decreased (P < 0.05) compared to the normal control group and T2DM group.
Conclusion

Speckle tracking echocardiography can effectively evaluate cardiac dysfunction in patients with T2DM. LA GLS and RA GLS can be used as potential markers of cardiac dysfunction in T2DM with hyperlipidemia, and provide the basis for early clinical diagnosis and treatment.
Sarcopenia Increases the Risk of Major Organ Invasion in Patients with Papillary Thyroid Cancer
Authors: Yoon Ja Kyung , Yoon Jung Hyun , Park Vivian Youngjean , Lee Minah , Kwak Jin Young 
Published: September 2021

Abstract
While sarcopenia is associated with poor overall survival and cancer-specific survival in solid cancer patients, the impact of sarcopenia on clinicopathologic features that can influence conventional papillary thyroid cancer (PTC) prognosis remains unclear. To investigate the impact of sarcopenia on aggressive clinicopathologic features in PTC patients, prospectively collected data on 305 patients who underwent surgery for PTC with preoperative staging ultrasonography and bioelectrical impedance analysis were retrospectively analyzed. Nine sarcopenia patients showed more patients aged 55 or older (p = 0.022), higher male proportion (p < 0.001), lower body-mass index (p = 0.015), higher incidence of major organ invasion (p = 0.001), higher T (p = 0.002) stage, higher TNM (p = 0.007) stage, and more tumor recurrence (p = 0.023) compared to the non-sarcopenia patients. Unadjusted and adjusted logistic regression analyses showed that sarcopenia (odds ratio (OR) 9.936, 95% confidence interval (CI) 2.052–48.111, p = 0.004), tumor size (OR 1.048, 95% CI 1.005–1.093, p = 0.027), and tumor multiplicity (OR 3.323, 95% CI 1.048–10.534, p = 0.041) significantly increased the risk of major organ invasion. Therefore, sarcopenia in PTC patients should raise suspicion for a more locally advanced disease and direct appropriate management.
D-Dimer is a Predictive Factor of Cancer Therapeutics-Related Cardiac Dysfunction in Patients Treated With Cardiotoxic Chemotherapy
Authors: Oikawa Masayoshi , Yaegashi Daiki , Yokokawa Tetsuro , Misaka Tomofumi , Sato Takamasa , Kaneshiro Takashi , Kobayashi Atsushi , Yoshihisa Akiomi , Nakazato Kazuhiko , Ishida Takafumi , Takeishi Yasuchika 
Published: September 2021

Abstract
Background: D-dimer is a sensitive biomarker for cancer-associated thrombosis, but little is known about its significance on cancer therapeutics-related cardiac dysfunction (CTRCD). Methods: Consecutive 169 patients planned for cardiotoxic chemotherapy were enrolled and followed up for 12 months. All patients underwent echocardiography and blood test at baseline, as well as at 3-month, 6-month, and 12-month. Results: The patients were divided into 2 groups based on the level of D-dimer (> 1.65 µg/ml or ≦ 1.65 µg/ml) at baseline before chemotherapy: High D-dimer group (n = 37) and low D-dimer group (n = 132). Left ventricular ejection fraction (EF) decreased at 3-month and 6-month after chemotherapy in high D-dimer group (baseline, 65.2% [62.8%-71.4%]; 3-month, 62.9% [59.0%-67.7%]; 6-month, 63.1% [60.0%-67.1%]; 12-month, 63.3% [58.8%-66.0%], P = 0.03), but no change was observed in low D-dimer group. The occurrence of CTRCD within the 12-month follow-up period was higher in high D-dimer group than in low D-dimer group (16.2% vs. 4.5%, P = 0.0146). Multivariable logistic regression analysis revealed that high D-dimer level at baseline was an independent predictor of the development of CTRCD (odds ratio 3.93, 95% CI [1.00-15.82], P = 0.047). Conclusion: Elevated D-dimer is a pivotal biomarker to predict CTRCD.
Identification of IGF2BP2 as a Prognostic Biomarker and Immunotherapeutic Target Based on Alternative Splicing Events in Glioblastoma
Authors: Li Xin-Yu , Hou Lei , Zhang Lu-yu , Li Xue-yuan , Yang xi-tao 
Published: September 2021

Abstract
Aim: A glioblastoma (GBM) prognostic model was developed with GBM -related alternative splicing (AS) data and prognostic markers were identified. Methods: AS data and clinical data of GBM patients were retrieved from The Cancer Genome Atlas (TCGA) SpliceSeq database and TCGA database, respectively. The data from these two databases were intersected to screen the prognosis-associated AS events, which was subsequently examined in Univariate Cox regression models. To avoid model overfitting, LASSO regression analysis was conducted. On the basis of these AS events, we established a prognostic model of GBM with the use of multivariate Cox regression analysis. On the strength of this model, the patients were assigned into high-risk and low-risk groups with a median risk score as the threshold. Kaplan-Meier survival, receiver operating characteristic (ROC), and calibration curves were applied to evaluate the performance of this model. Finally, combined with the risk model and clinicopathological characteristics, Cox regression analysis was utilized to identify the independent prognostic markers of GBM, and a nomogram was constructed. Results: The AS and clinical data of 169 GBM patients from the TCGA SpliceSeq and TCGA databases were collected. Univariate Cox regression analysis identified 1000 prognosis-related AS events in GBM, and then Lasso regression analysis identified 16 AS events. A GBM prognostic risk model was constructed based on AS events of 7 genes (FAM86B1, ZNF302, C19orf57, RPL39L, CBLL1, RWDD1, IGF2BP2). Through this model, we found lower overall survival (OS) rates of the high-risk population versus the low-risk population (p < 0.05). ROC and calibration curve analyses demonstrated the good ability of this model to predict the OS of GBM patients. Cox regression analysis suggested risk score as an independent prognostic factor for GBM. We also found that IGF2BP2 is associated with patient prognosis and have a strong relationship with immunotherapy response. Conclusion: The prognostic model based on AS events can significantly distinguish the survival rate of high-risk and low-risk GBM patients and IGF2BP2 were identified as a novel prognostic biomarker and immunotherapeutic target.
Correlation Between Immune-related Adverse Events and Therapeutic Effects of Nivolumab in Patients With Malignant Pleural Mesothelioma
Authors: Yoneda Hiroto , Nokihara Hiroshi , Mitsuhashi Atsushi , Ozaki Ryohiko , Yabuki Yohei , Ogino Hirokazu , Otsuka Kenji , Nishioka Yasuhiko 
Published: September 2021

Abstract
Background: Nivolumab is used for the treatment of malignant pleural mesothelioma (MPM). However, immune-related adverse events (irAEs) occur in patients treated with nivolumab. Several studies have reported the correlation between irAEs and therapeutic effects of immune checkpoint inhibitor, but none have reported the correlation in MPM. Here we report a retrospective study which shows the correlation between irAEs and therapeutic effects of nivolumab in patients with MPM. Methods: This study included patients treated with nivolumab at Tokushima University Hospital from February 2009 to December 2019. We retrospectively reviewed the medical records to evaluate the several clinical factors, such as the presence or absence of irAEs, their severities, progression-free survival (PFS), overall survival (OS) or objective response to the treatment.Results: Eight patients received treatment with nivolumab. Overall response rate was 14.3% and the disease control rate was 87.5%. Median PFS was 6.6 months (95% confidence interval, 2.4 to 10.8 months) and median OS was 15.2 months (95% confidence interval, 11.1 to 19.4 months). IrAEs occurred in six patients (85.7%), and grade 2 ≤ irAEs occurred in four patients (50.0%). Median PFS was significantly longer in the grade 2 ≤ irAEs group (16.3 months) than in their counterpart (3.8 months; p = 0.0266).Conclusions: This is the first study to report the correlation between irAEs and therapeutic effects in patients with MPM. Because the presence of irAEs may be associated with a favorable clinical outcome, early detection and appropriate management of irAEs will increase the therapeutic benefits to patients.
Lipid Risk Factors of Coronary Heart Disease in Postmenopausal Women with Statins based on NMR Metabolomics
Authors: Li Chuang , CHEN Jingxun , Wei Siyue , Zhang Mei , Chu Yushun , Meng Fanpeng , Wang Jianyu , Tang Jie , Luo Jian , Yang Yu , Niu Xiulong , Cai Wei 
Published: September 2021

Abstract
Background The role of nuclear magnetic resonance (NMR) metabolomics in the prevention of coronary heart disease (CHD) in postmenopausal women is unclear.Objective To explore the NMR measured risk factors of CHD and the correlation among Gensini score, proprotein convertase subtilisin/kexin type-9 (PCSK9) and NMR metabolomics.Method 300 postmenopausal women who were under moderate intensity statins were enrolled and assigned into CHD Group (242) and non-CAHD Group (58). Multivariate Logistic regression and Spearman correlation analysis were conducted for the risk factors of CHD and the relationship among Gensini score, PCSK9 and NMR results in all patients as well as the patients with CHD, diabetes mellitus (DM) and metabolic syndrome (MS). ResultsAge, the particle of LDL-6, LDL-6- triglyceride (TG) and LDL-6-free cholesterol (FC) were risk factors of CHD, while, glycerol were the protective factors of CHD. Lipoprotein contents of very-low-density lipoprotein (VLDL)-2 ~ VLDL-5, intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL)-1 and LDL-2 were positively related to Gensini score, while the lipoprotein contents, apolipoprotein A1 (ApoA1) and ApoA2 of high-density lipoprotein (HDL)-1 ~ HDL-4 showed negative correlations with Gensini score. PCSK9 was negatively correlated to the particles of VLDL, IDL and LDL, total cholesterol (TC), ApoB/A1, and nearly all the lipid contents in VLDL-3 ~ VLDL-5, IDL and LDL-1.ConclusionIn postmenopausal women, under moderate intensity statins, age, and the NMR measured particle of LDL-6, LDL-6-TG and LDL-6-FC were risk factors of CHD, while glycerol were the protective factors of CHD. Lipoprotein contents of VLDL-2 ~ VLDL-5, IDL, LDL-1 and LDL-2 maybe the residual risk factors of CHD in postmenopausal women, who is under moderate intensive statin.
Impact of Electromagnetic Stirring on the Gas Metal Arc Welding of an MAR-M247 Superalloy
Authors: Tzeng Yu-Chih , Lu Cheng-Yu , Chen RenYu 
Published: September 2021

Abstract
In this paper, the impact of electromagnetic stirring (EMS) on the gas metal arc welding (GATW) of an MAR-M247 superalloy was investigated. Results revealed that, without electromagnetic stirring, it was easy for carbides in the heat-affected zone (HAZ) of the weld bead to liquefy during welding, leading to weld bead cracks. Electromagnetic stirring refined the grains in the HAZ and the weld bead, leading to grain strengthening and subsequently resulting in the effective improvement in the hardness of the weld bead. In addition, electromagnetic stirring significantly facilitated the formation of the weld bead by the removal of large inclusions which in turn effectively improved crack resistance at the joint. It also accelerated the floating up of gas holes thereby reducing the generation of gas hole defects.
Bipolar Plasma Kinetic Vaporization Resection in the Management of Benign Anastomotic Stricture after Rectal Cancer Surgery: A Report of 12 Cases
Authors: Zhang Shaopeng , Xiao Mingming , Wu Song , pan guoqiang , kong yuan , li wei 
Published: September 2021

Abstract
Background: Postoperative anastomotic stricture is a common complication after kinds of rectal cancer surgery, especially in low anterior resection and anal retention patients. Currently, various of treatments including anal expansion, endoscopic dilation and also surgery are applied with different efficacy and safety. Besides, bipolar plasma kinetic vaporization resection is a technique used to be applied for benign prostatic hyperplasia with minimally invasion and high safety. To the best of my knowledge, it had not been reported to be applied for narrow scars after rectal surgery.Methods: To analysis retrospectively the clinical data of 12 patients who suffered anastomotic strictures after rectal cancer surgery in the First Hospital of Jilin University from Feb 2015 to December 2017. Result：All of them were successfully treated by the technique of once bipolar plasma kinetic vaporization resection in 8 cases, twice in 3 cases, and more times in 1 cases without occurrence of additional complications. Conclusions: Demonstrated by these limited cases, bipolar plasma kinetic vaporization resection would be applied as an alternative method in the treatment of postoperative anastomotic strictures due to its advantages as well as its effectiveness and safety.
Synthesis and Macrocyclization-Induced Emission Enhancement of Benzothiadiazole-based Macrocycle
Authors: Li Chunju , Bai Yue-Ling , Cui Lei , Li Shuo 
Published: September 2021

Abstract
We presented a novel strategy for the improvement of luminophore’s solid-state emission, i.e., macrocyclization-induced emission enhancement (MIEE), by linking luminophores through C(sp3) bridges to give a macrocycle. Benzothiadiazole-based macrocycle (BT-LC) has been synthesized by a one-step condensation of the monomer 4,7-bis(2,4-dimethoxyphenyl)-2,1,3-benzothiadiazole (BT-M) with paraformaldehyde, catalyzed by Lewis acid. BT-LC shows strong emission in both dilute solution and aggregated state. Moreover, in comparison with the monomer, macrocycle BT-LC produces much more intense fluorescence in the solid state (ΦPL=99%) and exhibits better device performance in the application of OLEDs. The MIEE can be ascribed to the restriction of intramolecular motion and the alleviation of the concentration quenching by the macrocyclic topological structure.
Polymeric Photonic Quasicrystal: Octonacci Sequence and Elasto-optic Effect
Authors: NAYAK Chittarajan , Jena Shuvendu , Rout Satyam , Suthar Bhuvneshwer , Udupa Dinesh V. 
Published: September 2021

Abstract
Here we would like to discuss the light transmission modulation by the one-dimensional polymeric quasi-multilayer which is formed according to substitutional generalized Octonacci with PMMA and PS as the constituent materials. In particular, we will present some theoretical findings using the well-known transfer matrix method. PBG inter-band spacing and depth can be managed by choosing the appropriate generation number. The number of PBGs is the same while increasing in the generation number and are shifted symmetrically towards the designed frequency. It also reveals the aroused forbidden frequency band can be manipulated by changing the applied hydrostatic pressure and the thickness of the constituent polymeric materials. The increase in pressure shows a blue shift in the PBGs while the increase in thickness of the polymeric material provides a redshift to PBGs. The proposed structure could be another possible system for optical device design specially multi-band tunable optical reflectors.
regCOVID: Tracking publications of registered COVID-19 studies
Authors: Mayer Craig , Huser Vojtech 
Published: September 2021

Abstract
In response to the COVID-19 pandemic many clinical studies have been initiated leading to the need for efficient ways to track and analyze study results. We expanded our previous project that tracked registered COVID-19 clinical studies to also track result articles generated from these studies. We conducted searches of ClinicalTrials.gov and PubMed to identify articles linked to COVID-19 studies, and developed criteria based on the trial phase, intervention, location, and record recency to develop a prioritized list of result publications. We found 760 articles linked to 419 interventional trials (15.7% of all 2 669 COVID-19 interventional trials as of 15 August 2021), with 418 identified via abstract-link in PubMed and 342 via registry-link in ClinicalTrials.gov. Of the 419 trials publishing at least one article, 123 (29.4%) have multiple linked publications. We used an attention score to develop a prioritized list of all publications linked to COVID-19 trials and identified 58 publications that are result articles from late phase (Phase 3) trials with at least one US site and multiple study record updates. For COVID-19 vaccine trials, we found 69 linked result articles for 40 trials (13.9% of 290 total COVID-19 vaccine trials). Our method allows for the efficient identification of important COVID-19 articles that report results of registered clinical trials and are connected via a structured article-trial link.