bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two birds one stone: semaglutide is highly effective against severe psoriasis in a type 2 diabetic patient
Authors: Costanzo Gabriele , Curatolo Salvatore , Busà Barbara , Belfiore Antonino , Gullo Damiano 
Published: August 2021

Summary
Semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist, approved for the treatment of type 2 diabetes mellitus (T2DM). GLP-1 analogs exert several biological activities connected not only with an insulinotropic effect but also with immunoregulation and reduction of inflammation. A 73-year-old male patient with class III obesity was referred to us for T2DM, which was not controlled with metformin therapy. He had suffered from plaque psoriasis for some years and was treated with topical therapy and adalimumab, without success. The psoriasis area and severity index (PASI) was 33.2 (indicating severe psoriasis), and the dermatology life quality index (DLQI) was 26.0 (indicating an extremely negative effect on the patient's life). Semaglutide (starting with 0.25 mg/week for 4 weeks, increased to 0.50 mg/week for 12 weeks, and then to 1 mg/week) was added to metformin. After 4 months, glycemic parameters had improved, and his body weight decreased. Unexpectedly, skin lesions of plaque psoriasis improved. PASI decreased by 19% compared with baseline and quality of life, assessed with the DLQI, markedly ameliorated. After 10 months, glycemic and obesity parameters, as well as psoriasis, improved further. HbA1c, BMI, and PASI were reduced by 32, 16.3, and 92%, respectively, compared with the baseline. DLQI declined to 0, meaning there was no effect of plaque psoriasis on the patient’s life.

Learning points

Psoriasis in patients with type 2 diabetes is often resistant to therapy.

We observed an obese patient with type 2 diabetes mellitus who achieved glycemic control and weight loss with the addition of semaglutide to metformin and had a relevant and long-lasting improvement of plaque psoriasis, which was previously resistant to biologic therapy.

Therapy with semaglutide may be attempted in eligible patients with difficult to treat plaque psoriasis.
Local Diagnostic Reference Levels for Paediatric Head CT Procedures
Authors: Gricienė Birutė , Šiukšterytė Monika 
Published: August 2021

Background. Patients, especially children, are exposed to substantially high doses of ionising radiation during computed tomography (CT) procedures. Children are several times more susceptible to ionising radiation than adults. Diagnostic reference levels (DRLs) are an important tool for monitoring and optimising patient radiation exposure from radiological procedures. The aim of this study is to estimate the ionising radiation exposure doses and set local DRLs for head CT examinations according to age and to compare local DRLs with national and European DRLs and with literature data in other countries.Materials and methods. Scan parameters of single-phase head CT examinations were collected. Patients were grouped by age in the following intervals: <1, 1−5, 5−10, 10−15 and 15−18 years. Local age-based DRLs set as the 3rd quartile of the median dose-length product (DLP) were calculated. Literature analysis was performed on PubMed search engine on inclusion criteria: publication date 2015–2020, used keywords paediatric computed tomography, paediatric CT, diagnostic reference levels (DRLs). The 23 articles discussing paediatric DRLs were further analysed.Results. Data was collected from 194 paediatric head CT examinations performed in 2019. The median DLP values for head CT were 144.3, 233.7, 246.4, 288.9, 315.5 for <1, 1−5, 5−10, 10−15 and 15−18 years old groups. Estimated local DRLs for head CT examinations are 170, 300, 310, 320, 360 mGy*cm for <1, 1−5, 5−10, 10−15 and 15−18 years age groups respectively and 130, 210, 275, 320 mGy*cm for 0−3 months, 3 months−1 year, 1−6 years and ≥ 6 years age groups respectively.Conclusions. Results of this study showed that settled new local DRLs of head CT examinations were 2–4 times lower than national DRLs and about 2 times lower than European DRLs. Moreover, the study indicated that paediatric head CT doses are significantly lower in comparison with those indicated in the majority of published data from other hospitals over the last 6 years. Patient dose assessment and local DRLs establishment plays important role in future exposure optimisation.
Congenital Syphilis Diagnosed Beyond the Neonatal Period in the United States: 2014–2018
Authors: Kimball Anne , Bowen Virginia B. , Miele Kathryn , Weinstock Hillard , Thorpe Phoebe , Bachmann Laura , McDonald Robert , Machefsky Aliza , Torrone Elizabeth 
Published: August 2021

BACKGROUND AND OBJECTIVES
During 2014–2018, reported congenital syphilis (CS) cases in the United States increased 183%, from 462 to 1306 cases. We reviewed infants diagnosed with CS beyond the neonatal period (&gt;28 days) during this time.

METHODS
We reviewed surveillance case report data for infants with CS delivered during 2014–2018 and identified those diagnosed beyond the neonatal period with reported signs or symptoms. We describe these infants and identify possible missed opportunities for earlier diagnoses.

RESULTS
Of the 3834 reported cases of CS delivered during 2014–2018, we identified 67 symptomatic infants diagnosed beyond the neonatal period. Among those with reported findings, 67% had physical examination findings of CS, 69% had abnormal long-bone radiographs consistent with CS, and 36% had reactive syphilis testing in the cerebrospinal fluid. The median serum nontreponemal titer was 1:256 (range: 1:1–1:2048). The median age at diagnosis was 67 days (range: 29–249 days). Among the 66 mothers included, 83% had prenatal care, 26% had a syphilis diagnosis during pregnancy or at delivery, and 42% were not diagnosed with syphilis until after delivery. Additionally, 24% had an initial negative test result and seroconverted during pregnancy.

CONCLUSIONS
Infants with CS continue to be undiagnosed at birth and present with symptoms after age 1 month. Pediatric providers can diagnose and treat infants with CS early by following guidelines, reviewing maternal records and confirming maternal syphilis status, advocating for maternal testing at delivery, and considering the diagnosis of CS, regardless of maternal history.
Entre a revolução, a instabilidade política e a ruptura democrática
Authors: Araujo Rafael Pinheiro de 
Published: August 2021

Em 10 de novembro de 2019, ocorreu mais um golpe de Estado na Bolívia. Evo Morales renunciou ao seu mandato presidencial após perder a “batalha das ruas” para as oposições políticas do país. O fatídico desfecho ocorreu após a sugestão de abdicação feita pelo comandante das Forças Armadas, general Williams Kaliman. A instabilidade política após a eleição presidencial em 20 de outubro contribuiu decisivamente para esse acontecimento. O tema despertou debates nos meios universitário e diversas análises jornalísticas. Paralelamente, exames sobre o assunto foram feitos por pesquisadores dedicados à história latino-americana. Almejamos contribuir com tais debates neste artigo. Refletiremos sobre a história boliviana entre 2006 e 2019. Avaliaremos os quase 14 anos de gestão de Evo Morales e as motivações para o golpe de Estado que finalizou com a revolução democrática e cultural boliviana.
Élő donoros vesetranszplantációt követő terhességben kialakult terápiarezisztens hypertonia
Authors: Borda Bernadett , Keresztes Csilla , Keresztúri Attila 
Published: August 2021

Összefoglaló. A veseátültetés a legnagyobb reményt nyújtja a
végstádiumú vesebetegségben szenvedő nők számára, akik teherbe kívánnak esni. A
veseátültetett beteg terhessége továbbra is kihívást jelent az immunszuppresszív
gyógyszerek mellékhatásai, az allograftfunkció romlásának kockázata, a
praeeclampsia és a magas vérnyomás káros anyai szövődményeinek rizikója,
valamint a koraszülés, az alacsony születési súly kockázata miatt. A terhesség
alatt nagy a magas vérnyomás kialakulásának kockázata, a szérum-kretaininszint
emelkedik, és a terhesség végére proteinuria is kialakulhat. Az ajánlott
fenntartó immunszuppresszió terhes nőknél a kalcineurininhibitorok
(takrolimusz/ciklosporin) és alacsony dózisú szteroid adása, melyek
biztonságosnak tekinthetők. Fontos, hogy a gyermekvállalási tanácsadás már a
vesetranszplantáció előtt megkezdődjön, és a transzplantációt követően minden
klinikai kontroll megtörténjen. Orv Hetil. 2021; 162(23): 924–926.
Summary. Kidney transplantation offers the best hope to women with
end-stage renal disease who wish to become pregnant. Pregnancy in a kidney
transplant recipient continues to remain challenging due to side effects of
immunosuppressive medication, risk of deterioration of allograft function, risk
of adverse maternal complications of preeclampsia and hypertension, and risk of
adverse fetal outcomes of premature birth, low birth weight, and small for
gestational age infants. The factors associated with poor pregnancy outcomes
include the presence of hypertension, serum creatinine greater than normal range
and proteinuria. The recommended maintenance immunosuppression in pregnant women
is calcineurin inhibitors (tacrolimus/cyclosporine) and low-dose steroid which
are considered safe. It is important that counseling for childbearing should
start as early as prior to getting a kidney transplant and should be done at
every clinic visit after transplant. Orv Hetil. 2021; 162(23): 924–926.
Proteins Associated with Risk of Kidney Function Decline in the General Population
Authors: Grams Morgan E. , Surapaneni Aditya , Chen Jingsha , Zhou Linda , Yu Zhi , Dutta Diptavo , Welling Paul A. , Chatterjee Nilanjan , Zhang Jingning , Arking Dan E. , Chen Teresa K. , Rebholz Casey M. , Yu Bing , Schlosser Pascal , Rhee Eugene P. , Ballantyne Christie M. , Boerwinkle Eric , Lutsey Pamela L. , Mosley Thomas , Feldman Harold I. , Dubin Ruth F. , Ganz Peter , Lee Hongzhe , Zheng Zihe , Coresh Josef 
Published: August 2021

Significance Statement
Proteomic profiling may allow identification of plasma proteins associated with subsequent changes in kidney function, elucidating biologic processes that underlie CKD. The authors used large-scale proteomic profiling to evaluate the association of 4877 plasma proteins with the development of adverse kidney outcomes in a cohort of 9406 middle-aged adults with a median follow-up of 14.4 years, and, in a subset of 4378 adults at a later time point, with a median follow-up of 4.4 years. They found 13 proteins for which higher levels were associated with greater kidney risk at both time periods, and 12 replicated in at least one external cohort. Although most proteins appeared to be markers, rather than causes, of kidney damage, genetic evidence suggested a causal role for lectin mannose-binding 2 protein (LMAN2).

Background
Proteomic profiling may allow identification of plasma proteins that associate with subsequent changesin kidney function, elucidating biologic processes underlying the development and progression of CKD.

Methods
We quantified the association between 4877 plasma proteins and a composite outcome of ESKD or decline in eGFR by ≥50% among 9406 participants in the Atherosclerosis Risk in Communities (ARIC) Study (visit 3; mean age, 60 years) who were followed for a median of 14.4 years. We performed separate analyses for these proteins in a subset of 4378 participants (visit 5), who were followed at a later time point, for a median of 4.4 years. For validation, we evaluated proteins with significant associations (false discovery rate <5%) in both time periods in 3249 participants in the Chronic Renal Insufficiency Cohort (CRIC) and 703 participants in the African American Study of Kidney Disease and Hypertension (AASK). We also compared the genetic determinants of protein levels with those from a meta-analysis genome-wide association study of eGFR.

Results
In models adjusted for multiple covariates, including baseline eGFR and albuminuria, we identified 13 distinct proteins that were significantly associated with the composite end point in both time periods, including TNF receptor superfamily members 1A and 1B, trefoil factor 3, and β-trace protein. Of these proteins, 12 were also significantly associated in CRIC, and nine were significantly associated in AASK. Higher levels of each protein associated with higher risk of 50% eGFR decline or ESKD. We found genetic evidence for a causal role for one protein, lectin mannose-binding 2 protein (LMAN2).

Conclusions
Large-scale proteomic analysis identified both known and novel proteomic risk factors for eGFR decline.
Removal of Crossed Artifacts from Multimodal Dispersion Curves with Modified Frequency–Bessel Method
Authors: Zhou Jie , Chen Xiaofei 
Published: August 2021

ABSTRACT
Frequency–Bessel (F-J) transform method can obtain higher-mode Rayleigh dispersion curves by multistation ambient noise data superposition (Wang et al., 2019). Because the dispersion curves of the overtones can provide more information compared with the single fundamental mode, the nonuniqueness of surface-wave inversion can be reduced. Because of the limited number of receivers, the integral in the process of transformation cannot be calculated precisely and there exists a kind of crossed artifacts which cuts off the real dispersion curves and contaminates the spectrum. Forbriger (2003) proposed to use the Hankel function instead of the Bessel function to conduct the transformation to remove the crossed artifacts. However, this method can reduce the resolution of the spectrum from ambient noise data. In this article, we give a complete workflow to deal with ambient noises which can eliminate the crossed artifacts without reducing the resolution. The Kramers–Kronig relations are used to obtain complete cross-correlation functions and a modified F-J transform is conducted to finally acquire the spectrum without crossed artifacts.
Application of a Hybrid Modeling Method for Generating Synthetic Ground Motions in Fennoscandia, Northern Europe
Authors: Jussila Vilho , Fälth Billy , Mäntyniemi Päivi , Voss Peter H. , Lund Björn , Fülöp Ludovic 
Published: August 2021

ABSTRACT
We present a modeling technique for generating synthetic ground motions, aimed at earthquakes of design significance for critical structures and ground motions at distances corresponding to the engineering near field, in which real data are often missing. We use dynamic modeling based on the finite-difference approach to simulate the rupture process within a fault, followed by kinematic modeling to generate the ground motions. The earthquake source ruptures were modeled using the 3D distinct element code (Itasca, 2013). We then used the complete synthetic program by Spudich and Xu (2002) to simulate the propagation of seismic waves and to obtain synthetic ground motions. In this work, we demonstrate the method covering the frequency ranges of engineering interests up to 25 Hz and quantify the differences in ground motion generated. We compare the synthetic ground motions for distances up to 30 km with a ground-motion prediction equation, which synthesizes the expected ground motion and its randomness based on observations. The synthetic ground motions can be used to supplement observations in the near field for seismic hazard analysis. We demonstrate the hybrid approach to one critical site in the Fennoscandian Shield, northern Europe.
Probabilistic Fault Displacement Hazard Assessment (PFDHA) for Nuclear Installations According to IAEA Safety Standards
Authors: Valentini Alessandro , Fukushima Yoshimitsu , Contri Paolo , Ono Masato , Sakai Toshiaki , Thompson Stephen C. , Viallet Emmanuel , Annaka Tadashi , Chen Rui , Moss Robb E. S. , Petersen Mark D. , Visini Francesco , Youngs Robert R. 
Published: August 2021

ABSTRACT
In the last 10 yr, the International Atomic Energy Agency (IAEA) revised its safety standards for site evaluations of nuclear installations in response to emerging fault displacement hazard evaluation practices developed in Member States. New amendments in the revised safety guidance (DS507) explicitly recommend fault displacement hazard assessment, including separate approaches for candidate new sites versus existing sites. If there is insufficient basis to conclusively determine that a fault is not capable of surface displacement at an existing site, then a probabilistic fault displacement hazard analysis (PFDHA) is recommended to better characterize the hazard. This new recommendation has generated the need for the IAEA to provide its Member States with guidance on performing PFDHA, including its formulation and implementation. This article provides an overview of current PFDHA state-of-practice for nuclear installations that is consistent with the new IAEA safety standards. We also summarize progress in an ongoing international PFDHA benchmark project that will ultimately provide technical guidance to Member States for conducting site-specific fault displacement hazard assessments.
Full-Waveform Inversion of High-Frequency Teleseismic Body Waves Based on Multiple Plane-Wave Incidence: Methods and Practical Applications
Authors: Wang Kai , Wang Yi , Song Xin , Tong Ping , Liu Qinya , Yang Yingjie 
Published: August 2021

ABSTRACTTeleseismic full-waveform inversion has recently been applied to image subwavelength-scale lithospheric structures (typically a few tens of kilometers) by utilizing hybrid methods in which an efficient solver for the 1D background model is coupled with a full numerical solver for a small 3D target region. Among these hybrid methods, the coupling of the frequency–wavenumber technique with the spectral element method is one of the most computationally efficient ones. However, it is normally based on a single plane-wave incidence, and thus cannot synthesize secondary global phases generated at interfaces outside the target area. To remedy the situation, we propose to use a multiple plane-wave injection method to include secondary global phases in the hybrid modeling. We investigate the performance of the teleseismic full-waveform inversion based on single and multiple plane-wave incidence through an application in the western Pyrenees and compare it with previously published images and the inversion based on a global hybrid method. In addition, we also test the influence of Earth’s spherical curvature on the tomographic results. Our results demonstrate that the teleseismic full-waveform inversion based on a single plane-wave incidence can reveal complex lithospheric structures similar to those imaged using a global hybrid method and is reliable for practical tomography for small regions with an aperture of a few hundred kilometers. However, neglecting the Earth’s spherical curvature and secondary phases leads to errors on the recovered amplitudes of velocity anomalies (e.g., about 2.8% difference for density and VS, and 4.2% for VP on average). These errors can be reduced by adopting a spherical mesh and injecting multiple plane waves in the frequency–wavenumber-based hybrid method. The proposed plane-wave teleseismic full-waveform inversion is promising for mapping subwavelength-scale seismic structures using high-frequency teleseismic body waves (&gt;1  Hz) including coda waves recorded at large N seismic arrays.
A Big Problem for Small Earthquakes: Benchmarking Routine Magnitudes and Conversion Relationships with Coda Envelope-Derived Mw in Southern Kansas and Northern Oklahoma
Authors: Shelly David R. , Mayeda Kevin , Barno Justin , Whidden Katherine M. , Moschetti Morgan P. , Llenos Andrea L. , Rubinstein Justin L. , Yeck William L. , Earle Paul S. , Gök Rengin , Walter William R. 
Published: August 2021

ABSTRACT
Earthquake magnitudes are widely relied upon measures of earthquake size. Although moment magnitude (Mw) has become the established standard for moderate and large earthquakes, difficulty in reliably measuring seismic moments for small (generally Mw&lt;4) earthquakes has meant that magnitudes for these events remain plagued by a patchwork of inconsistent measurement scales. Because of this, magnitudes of small earthquakes and statistics derived from them can be biased. Furthermore, because small earthquakes are much more numerous than large ones, many applications, such as seismic hazard modeling, depend critically on analysis of events characterized by magnitudes other than Mw. To assess this problem, we apply coda envelope analysis to reliably determine moment magnitudes for a case study of small earthquakes from northern Oklahoma and southern Kansas. Not surprisingly, we find significant differences among ML, mbLg, and Mw for M ∼2–4 earthquakes examined here. More troublingly, we find that relations designed to convert other magnitudes to Mw, which are relied upon for important applications such as seismic hazard analysis, often increase rather than decrease this bias for our dataset. In our case study, we find that converted magnitudes can result in a systematic bias sometimes exceeding 0.5 magnitude units, a difference that typically corresponds to a factor of ∼3 in seismicity rate. Moreover, we find a correspondingly large bias in Gutenberg–Richter b-values, controlled primarily by inaccurate magnitude scaling in the conversion relationships. Although this study focuses on a relatively small geographic area, we can expect that similar issues exist with varying severity in other regions. Therefore, magnitudes of small earthquakes and their associated statistics, including seismicity rates and b-values, should be treated with caution.
Green Marketing Tools, Religiosity, Environmental Attitude And Green Purchase Behaviour Among Millenials Generation
Authors: Solekah Nihayatu Aslamatis , Premananto Gancar , Hartini Sri 
Published: August 2021

The purpose of the research isto examine relationship between Green Marketing Tools (GMT), Environmental Attitudes (EA), Religiosity and Green Purchase Behavior (GPB) and test Religiosity moderates between Environmental Attitudes (EA) and Green Purchase Behavior (GPB). This study employs samples using a questionnaire instrument. The result of the collected 268 questionnaires of respondents were processed using descriptive and quantitative analysis data using SEM (Strutural Equation Model) analysis techniques with Stata 13. The results showed that millennial generation in shaping their engagement behavior on environmental issues is influenced by environmentally friendly advertisements, attributes or labels used on a product, then perceptions of environmentally friendly brands and trust in environmentally friendly advertisements, trust in compliance or environmentally friendly labels and brands that are on the products they know.The findings of this study suggest that individual factors in the form of religious and situational factors in the form of green marketing tools in the form of eco labels, eco brands, trusts or trust in eco labels and eco brands, and environmental advertising affect green behavioral.