bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Analysis of Immune Signature Genes in Th1* Memory Cells Links ISOC1 and Pyrimidine Metabolism to IFN-γ and IL-17 Production
Authors: Kushnareva Yulia , Mathews Ian T. , Andreyev Alexander Y. , Altay Gokmen , Lindestam Arlehamn Cecilia S. , Pandurangan Vijayanand , Nilsson Roland , Jain Mohit , Sette Alessandro , Peters Bjoern , Sharma Sonia 
Published: February 2021

Abstract
CCR6+CXCR3+CCR4−CD4+ memory T cells, termed Th1*, are important for long-term immunity to Mycobacterium tuberculosis and the pathogenesis of autoimmune diseases. Th1* cells express a unique set of lineage-specific transcription factors characteristic of both Th1 and Th17 cells and display distinct gene expression profiles compared with other CD4+ T cell subsets. To examine molecules and signaling pathways important for the effector function of Th1* cells, we performed loss-of-function screening of genes selectively enriched in the Th1* subset. The genetic screen yielded candidates whose depletion significantly impaired TCR-induced IFN-γ production. These included genes previously linked to IFN-γ or M. tuberculosis susceptibility and novel candidates, such as ISOC1, encoding a metabolic enzyme of unknown function in mammalian cells. ISOC1-depleted T cells, which produced less IFN-γ and IL-17, displayed defects in oxidative phosphorylation and glycolysis and impairment of pyrimidine metabolic pathway. Supplementation with extracellular pyrimidines rescued both bioenergetics and IFN-γ production in ISOC1-deficient T cells, indicating that pyrimidine metabolism is a key driver of effector functions in CD4+ T cells and Th1* cells. Results provide new insights into the immune-stimulatory function of ISOC1 as well as the particular metabolic requirements of human memory T cells, providing a novel resource for understanding long-term T cell–driven responses.
Senior Interior Design Students’ Perceptions about Distance Learning in the Shadow of Covid-19
Authors: Fallatah Samaher A. 
Published: February 2021

Background Like many international universities and institutions of higher education that have shifted the entire educational system from the traditional face-to-face education model to distance learning during the COVID-19 pandemic, universities in Saudi Arabia have expended great effort to change the behavior of educators and students to accommodate the transition. This rapid shift has had a significant impact on students, especially in programs such as interior design, in which different practical courses are taught along with the theoretical ones. Therefore, this study aimed to investigate the benefits and challenges senior interior design students experienced while taking their classes online. Design and Methods The current paper has adopted a qualitative approach for assessing the data obtained. Semi-structured interview was used to collect all the needed information regarding participants’ opinions about distance learning. Results Increased time to spend on assignments, reduction of costs to the student, and improvement in achievement of learning outcomes were the three main benefits students reported in their experience of distance learning. On the other hand, technical issues, changes in grade distribution, and changes in project types were identified as student concerns. Although students found many advantages in communicating with others remotely, some issues arose. Conclusions Students expressed a preference for the hybrid learning method, or at least for having their exams, juries, and presentations on campus in person, not remotely.
Assessment of the Work Conditions of Small Slaughterhouses in the Thi-Qar Governorate in Iraq
Authors: Naser Abed Sameeha , Kadhim Rusul Abdulhameed , Abbas Dhakam Mohammed 
Published: February 2021

Background Working conditions have a vital role to play in determining health and disability. So, the objective of this study was to assess the work conditions of small slaughterhouses in the Thi-Qar governorate in Iraq. Design and methods This study is a cross-sectional field survey. A total of twenty-six (26) small slaughterhouses were included as a sample size from the Thi-Qar governorate. The data collection was done by observations of the authors using a questionnaire and specific questions were also directed to the slaughterhouse workers if needed. It was conducted between February and April 2018. The study was planned to demonstrate the current status of small slaughterhouses in terms of water supply facilities, quality of small slaughterhouses building, sanitation practices. Results All of the small slaughterhouses had a water supply and all they had hot and cold water. Most of the small slaughterhouses had water tanks and put water pipes away from slaughter sites. The proportions ranged from 76.9 to 96.0 for the quality of small slaughterhouses building. With regard to fire safety measures, 96.2% of buildings are supplied with mobile fire extinguishing equipment according to safety and security requirements. Concerning rodent and insects’ control, sixteen (61.5%) of small slaughterhouses use insecticides and pesticides and only six (23.1%) of them use traps for rodents. Most of the small slaughterhouses’ windows (88.5%) were covered with a thin net to prevent the insects from entering. Conclusions The finding of this study indicated that work conditions of small slaughterhouses were generally adequate in terms of water supply facilities, sanitation practices, ventilation, fire safety measures, and rodents and insects’ control.
Desflurane Versus Sevoflurane in Laparoscopic Cholecystectomy
Authors: Gahlot Divya , Ahuja Sharmila , Yadav Neha , Choudhary Sujata 
Published: February 2021

Context:
Laparoscopic cholecystectomy is one of the most commonly performed minimal access surgeries nationwide, safely done as a day care procedure. Anesthetic techniques facilitating early recovery and home discharge have become the need of the hour.

Aims:
To compare early, intermediate, late recovery characteristics and time to home readiness following use of sevoflurane or desflurane as maintenance anesthesia in laparoscopic cholecystectomy in Indian subpopulation. In addition, postoperative complications such as coughing and shivering and total antiemetic and analgesic requirements postoperatively were also noted.

Settings and Design:
This was a prospective randomized study, and randomization was done by computerized random number table into two groups (30 patients in each group). Group S received sevoflurane and Group D received desflurane as maintenance agent.

Subjects and Methods:
Sixty patients of age group 18–60 years belonging to the American Society of Anesthesiologists Grade I and II undergoing laparoscopic cholecystectomy were recruited. A standard anesthesia induction was done and airway was secured with a ProSeal laryngeal mask airway of appropriate size. The patients subsequently received either sevoflurane 1%–2% or desflurane 3%–6% with 60% N2 O in O2 as per group assigned. Inhalational agent was discontinued at the time of endoscope removal. Early, intermediate, and late recovery parameters were noted.

Statistical Analysis:
The tests of significance used were parametric test (unpaired t-test) and ANOVA. The outcome measures were compared statistically using unpaired t-test and ANOVA, and P < 0.05 was considered statistically significant.

Results:
Early recovery parameters were achieved faster in patients receiving desflurane as compared to sevoflurane with no difference in time to achieve intermediate recovery and home readiness.

Conclusion:
Despite a faster early recovery with desflurane, no additional benefit in terms of home discharge and patient satisfaction was found, thus making use of either of the agents suitable for laparoscopic cholecystectomy on a day care basis.
Factors Influencing Patient Safety Culture in Saudi Arabia: A Systematic Review
Authors: Al abbas Anood M. 
Published: February 2021

ABSTRACT
Context: Patient safety, which is concerned with preventing harm to patients, has already become a vital element of the global healthcare system. The evidence relating to the status of the patient safety culture in Arab countries suggests that it is at a sub-optimal level because of a punitive approach to errors and deficits in communications openness.
Aim: The given review aimed to identify the relevant evidence related to factors influencing patient safety culture in Saudi Arabia hospitals from patients and health care provider perspectives.
Methods: A systematic search was conducted in five electronic databases—MEDLINE, CINAHL, Embase, PsycINFO, and the Cochrane Database of Systematic Reviews. Related papers and reference lists of included studies were also hand-searched. One reviewer verified that the research met the inclusion criteria, assessed the research quality, and extracted their relevant features. The Yorkshire Contributory Factors Model (YCFF) was used to categorize factors influencing safety culture in the included documents.
Results: 14 documents were included, and most research was appraised as being satisfactory to high quality. Strength and weakness factors that are influencing patient safety culture have been identified. In Saudi Arabia, ineffective leadership, a blame culture, workload/inadequate staffing, and poor communication are key factors hindering a positive patient safety culture. Conversely, 'strength' factors influencing a positive patient safety culture included good teamwork within units, realistic manager expectations and supportive actions promoting patient safety, and organizational attitudes to learning/continuous improvement. There is an absence of patient perspectives about patient safety culture in Saudi Arabian studies.
Conclusion: In the Saudi healthcare system, policymakers should pay attention to factors that may influence a positive patient safety culture, particularly the development of a blame-free culture, improving communications and leadership ability, learning from mistakes, and involving patient perspectives in safety initiatives. Further study must understand the barriers and facilitators in Saudi Arabia Hospitals to implement a positive patient safety culture.
Efecto relativo de la edad en el circuito profesional de Pádel (The relative age effect in the professional Padel circuit)
Authors: Muñoz Moreno Alejandro , Serrano Gonzalez Carla , Quintana-García Iñaki , Granado Peinado Miriam 
Published: February 2021

El pádel ha pasado a ser a uno de los deportes más practicados en España. El propósito de este estudio fue evaluar el Efecto Relativo de la Edad (RAE) en los jugadores del circuito de World Pádel Tour (WPT) (n=395) teniendo en cuenta el mes de nacimiento, género, nacionalidad, edad y ranking. La distribución trimestral observada no fue significativamente diferente (χ2; p>.05) a la esperada para el grupo general o para cualquiera de las subcategorías analizadas. Por tanto, no parece confirmarse un efecto de la edad relativa en los jugadores profesionales de pádel analizados, considerando el ranking, género y nacionalidad, a diferencia de lo que ocurre en otros deportes de raqueta. En este sentido, esta investigación constata que la fecha de nacimiento no es un factor relevante en el circuito de WPT y confirma que llegar a la élite del pádel no se basa exclusivamente en factores físicos y antropométricos.
Abstract: Padel has become one of the most practiced sports in Spain. The purpose of this study was to evaluate the Relative Effect of Age (RAE) in the World Padel Tour (WPT) circuit players (n = 395) taking into account the month of birth, gender, nationality, age and ranking. The quarterly distribution observed was not significantly different (χ2; p> .05) than expected for the general group or for any of the subcategories analyzed. Therefore, it does not seem to confirm an effect of relative age on professional padel players analyzed, considering the ranking, gender and nationality, unlike what happens in other racket sports. Thus, this investigation confirms that the date of birth is not a relevant factor in the WPT circuit and confirms that reaching the elite of the paddle that is not based exclusively on physical and anthropometric factors.
Qualidade de vida de professores do ensino superior: uma revisão sistemática (Quality of life of higher education teachers: a systematic review)
Authors: Araldi Franciane Maria , Poulsen Fernanda Feijó , De Azevedo Guimarães Adriana Coutinho , Oliveira Farias Gelcemar , Folle Alexandra 
Published: February 2021

Essa revisão sistemática teve como objetivo mapear os artigos publicados sobre qualidade de vida de professores atuantes em cursos de Ensino Superior. Buscou-se artigos originais nas seguintes bases de dados eletrônicas: Lilacs; Web of Science; Proquest; Scielo; e Science Direct, sem delimitação de abrangência temporal. Após a seleção dos estudos foi realizada a análise por meio de categorias e de frequência absoluta (QSR NVIVO). As informações obtidas revelaram que a investigação da qualidade de vida de professores do Ensino Superior é incipiente na literatura, apesar de estar em crescimento na última década (2009 a 2019) e os professores universitários das regiões Sul e Sudeste do Brasil têm sido os mais estudados. O Whoqol têm sido o instrumento preconizado para a investigação da temática e da população em destaque nessa revisão. A análise da percepção geral evidenciou que os docentes avaliam positivamente sua qualidade de vida e os domínios psicológico, relações sociais e meio ambiente, enquanto o domínio físico tem sido avaliado em algumas pesquisas de forma regular.

Abstract. This systematic review aimed to map the published articles on the quality of life of teachers working in higher education courses. Original articles were searched from the following electronic databases: Lilacs; Science web; Proquest; Scielo; and Science Direct, without delimitation of temporal scope. After the selection of the studies, the analysis was performed through categories and absolute frequency (QSR NVIVO). The information displayed reveals that research on the quality of life of higher education teachers is incipient in the literature, despite being growing in the last decade (2009 to 2019) and university teachers from the South and Southeast regions of Brazil were the most studied. Whoqol has been the recommended tool for research of the theme and the population highlighted in this review. A general perception analysis shows that the documents positively evaluate their quality of life and the psychological domains, social relations and environment, while the physical domain was evaluated in some regular research.
Estrategias didácticas de educación física para mejorar el rendimiento académico de estudiantes universitarios con base en gimnasia cerebral de Paul Dennison (Didactic physical education strategies to improve the academic performance of college students
Authors: Ramírez Ramírez Wildoro , Vasquez Ruiz Ledmy , Palacios Paredes Wendy Lilly 
Published: February 2021

En el presente trabajo se estudia la influencia de estrategias didácticas de educación física basadas en ejercicios de gimnasia cerebral de Paul Dennison en el rendimiento académico de estudiantes universitarios del primer ciclo de la Facultad de Ciencias Económicas de la Universidad Nacional de San Martin en Perú. La muestra estuvo conformada por 120 estudiantes, y fue escogida de forma probabilística en muestreo estratificado y se formaron dos grupos, uno Control con 68 estudiantes y uno Experimental con 52 estudiantes. Originalmente se estudió la homogeneidad de las calificaciones de los estudiantes en 4to y 5to años de secundaria en Matemática y Comunicación mediante análisis de normalidad y prueba U de Mann-Whitney y luego al grupo Experimental se intervino mediante ejercicios de educación física basados en gimnasia cerebral durante todo el ciclo académico, dejando al grupo Control sin intervenir. Al final del ciclo se recolectaron las calificaciones de Matemática y Comunicación de ambos grupos y se analizaron estadísticamente mediante prueba U de Mann-Whitney para establecer las diferencias entre los grupos y la influencia de la intervención, con significancia α = 0,05. Se demostró que se produjo diferencia estadísticamente significativa entre las calificaciones de los dos grupos de estudio (Valor-p < 0,05) con nivel de confianza de 95%, con mayores notas en el grupo experimental, atribuidas a la intervención realizada.
Abstract: This paper studies the influence of physical education teaching strategies based on Paul Dennison's brain gym exercises on the academic performance of university students in the first cycle of the Faculty of Economics at the National University of San Martin in Peru. The sample was made up of 120 students, and was chosen probabilistically in a stratified sample and two groups were formed, a Control group with 68 students and an Experimental group with 52 students. Originally, the homogeneity of the grades of students in 4th and 5th years of secondary school in Mathematics and Communication was studied by means of normality analysis and Mann-Whitney U test. Then, the Experimental group was intervened by means of physical education exercises based on brain gym during the whole academic cycle, leaving the Control group without intervention. At the end of the cycle the Math and Communication scores of both groups were collected and statistically analyzed by Mann-Whitney Utest to establish the differences between the groups and the influence of the intervention, with significance α = 0.05. It was demonstrated that there was a statistically significant difference between the scores of the two study groups (p-value < 0.05) with 95% confidence level, with higher scores in the experimental group, attributed to the intervention performed.
Actitudes hacia la Expresión Corporal en el ámbito de la asignatura de Educación Física: Un estudio con alumnado de Educación Secundaria Obligatoria (Attitudes towards Body Expression in the field of Physical Education subject: A study with Compulsory Se
Authors: Arias García José Roberto , Fernández Díez Beatriz , Valdés González Rodrigo 
Published: February 2021

El objetivo de este estudio fue llevar a cabo una investigación en la que se analizaban las Actitudes hacia la Expresión Corporal de los alumnos de Educación Secundaria en el marco de la asignatura de Educación Física. Para realizar dicho estudio se contó con una muestra de 692 estudiantes de Educación Secundaria Obligatoria, con edades comprendidas entre los 12 y 18 años. Todos ellos pertenecientes a ocho institutos diferentes de la ciudad de Valladolid. El instrumento utilizado fue un cuestionario, fruto de un trabajo previo (Arias, Fernández & San Emeterio, 2020), compuesto por 32 ítems que atendían a diferentes factores (Valoración de la EC, Preferencia, Agrado o gusto y Actitud del profesor). Tras un análisis inferencial podemos destacar, como resultados importantes, que la actitud de los alumnos hacia la Expresión Corporal se ve influenciada por la actitud que perciban en el profesor hacia esta materia. También se analizó la influencia que pueden tener las variables sexo, edad, curso y tipo de centro con respecto al constructo Actitud del alumnado hacia la Expresión Corporal. Resultado del análisis destacamos la correlación existente entre las variables sexo y tipo de centro y dicho constructo.
Abstract. The aim of this study was to carry out an investigation that analysed Attitudes towards Body Expression. To construct this study, there was a sample of 692 students belonging to the E.S.O, aged between 12 and 18 years. All of them belong to eight different high schools in the city of Valladolid. The instrument used was a questionnaire, the result of a previous work (Arias, Fernández & San Emeterio, 2020), made up by 32 items that addressed different factors (Assessment of the CE, Preference, Liking and Attitude of the teacher). After an inferential analysis we can highlight, as main results, the students’ attitude towards Corporal Expression, it will be influenced by the attitude they perceive in their teacher. The influence that the variables sex, age, grade and type of center may have with respect to the construct Attitude of students towards Body Expression was also analyzed. Result of the analysis, we highlight the correlation between the variables sex and type of center and said construct.
Influencia del perfil de los jóvenes en sus valores del cuerpo (Influence of the profile of young people on their body values)
Authors: Velasco-Santos Lorena , Pastor Pradillo José Luis , Blanco-Alcántara David , Jiménez Eguizábal Alfredo 
Published: February 2021

El presente artículo analiza los valores del cuerpo de 536 estudiantes de 1º Bachillerato en Castilla y León en el curso 2017/18 en función de sus variables de perfil sexo, modalidad de bachillerato, naturaleza, titularidad y provincia de pertenencia del centro de estudios. El objetivo es describir tendencias generales asociadas a dichas variables de perfil. El instrumento de medida es el test elaborado por Casares y Collados (1998) que clasifica en 10 los valores del cuerpo en base a 250 ítems agrupados en bloques de 25. El tratamiento de datos se lleva a cabo mediante un análisis de valores medios. Los resultados obtenidos son mostrados en forma de tablas de puntuaciones, gráficos y representaciones jerárquicas. Se calculan estadísticos descriptivos y estadística inferencial. Se observan diferencias estadísticamente significativas asociadas a la variable de perfil sexo y, secundariamente, provincia de pertenencia del centro de estudios. Asimismo, destaca el valor placer como el más agradable en todas las clasificaciones y el valor religioso el menos, exceptuando lo ocurrido en Soria donde se torna incluso positivo. Todo ello describe la realidad en que los estudiantes de 1º bachillerato conciben su cuerpo y le conceden su valor, lo que abre nuevos flancos críticos en la educación a través de los valores del cuerpo.
Abstract. This article analyzes the body values of 536 First Year Bachillerato students in the Castilla y León region of Spain during the academic year 2017/18 according to their special characteristics such as gender, Bachillerato option, personality, qualifications and province administering the educational establishment they attend. The aim is to describe general trends associated with these profile variables. The instrument of measurement is the test devised by Casares and Collados (1998), which divides body values into 10 categories. It is based on 250 items classified into 10 groups of 25 defining the body values. Data processing is carried out through an analysis of average values. The results obtained are shown in the form of score tables, graphs and hierarchical representations. Descriptive statistics and inferential statistics are calculated. Significant differences associated to the variable of gender profile and, secondarily, province of belonging to the study center are highlighted. Likewise, the pleasure value stands out as the most pleasant in all classifications and the religious value the least, except for what happened in Soria where it becomes even positive. The procedure of preferred values ratifies the pleasure value as the most pleasant, however the religious value is rarely the least preferred. All this describes the reality in which the students of the 1st baccalaureate conceive their body and give it their value, which opens new critical flanks in education through the values ​​of the body.