bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered Experienced Thermoregulation in Depression—No Evidence for an Effect of Early Life Stress
Authors: von Salis Sarina , Ehlert Ulrike , Fischer Susanne 
Published: July 2021

Objectives: Accumulating evidence suggests that individuals with depression are characterised by difficulties in thermoregulatory cooling. The aim of this study was to investigate, for the first time, whether depressed individuals are aware of these alterations, what their physical consequences are and whether they may be rooted in early life stress.Methods: A total of N = 672 medically healthy individuals from the general population were recruited to participate in an online survey. Participants were divided into depressed vs. non-depressed using the Patient Health Questionnaire. Experienced autonomic and behavioural thermoregulation as well as vigilance problems in response to temperature increases were assessed by the Experienced Temperature Sensitivity and Regulation Survey. The Childhood Trauma Questionnaire was administered to assess early life stress.Results: Controlling for age, sex, body mass index, and physical activity, depressed vs. non-depressed individuals did not differ in their experienced autonomic and behavioural responses to temperature increases. However, the depressed individuals reported comparably greater difficulties in concentrating and drowsiness/fatigue in warm environments (p = 0.029), during physical exertion (p = 0.029), and during stress (p &lt; 0.001). There were no differences in the experienced thermoregulation between depressed individuals with vs. without early life stress.Conclusions: Depressed individuals experienced more severe physical impairments (i.e., greater vigilance problems) in response to intense warmth when compared to non-depressed individuals. These differences were not attributable to comorbid illnesses, the intake of medication, or physical deconditioning. Further enquiries in clinical populations are warranted to investigate to what extent the observed alterations map onto specific symptoms of depression (e.g., sleep disturbances).
Paricalcitol versus Calcitriol + Cinacalcet for the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease in China: A Cost-Effectiveness Analysis
Authors: Zhang Zhuolin , Cai Lele , Wu Hong , Xu Xinglu , Fang Wenqing , He Xuan , Wang Xiao , Li Xin 
Published: July 2021

Background: Chronic Kidney Disease (CKD) is a global chronic disease with increasing prevalence in recent years, particularly CKD accompanied by Secondary Hyperparathyroidism (SHPT) leads to reduced quality of life, increased mortality, a considerable economic burden for patients and society. The aim of this study was to investigate the cost-effectiveness analysis of paricalcitol vs. calcitriol + cinacalcet for CKD patients with SHPT in China in 2020.Methods: A Markov model was conducted employing data derived from published literature, clinical trials, official sources, and tertiary public hospital data in China, based on a 10-year horizon from the perspective of the healthcare system. Calcitriol + Cinacalcet was used as the reference group. CKD stage 5 (CKD-5) dialysis patients suffering from SHPT were included in the study. Effectiveness was measured in quality-adjusted life years (QALYs). The discount rate (5%) was applied to costs and effectiveness. Sensitivity analysis was performed to confirm the robustness of the findings.Results: The base case analysis demonstrated that Patients treated with paricalcitol could gain an increase in utility (0.183 QALYs) and require fewer expenditures (6925.612 yuan). One-way sensitivity analysis was performed to showed that impact factors were the price of cinacalcet, the hospitalization costs of patients with paricalcitol and calcitriol, the costs and utilities of hemodialysis and the costs of calcitriol, the costs of paricalcitol regardless of period. Probabilistic simulation analysis displayed when willingness-to-pay was ¥217113, the probability that Paricalcitol was dominant is 96.20%.Conclusion: The results showed that paricalcitol administrated to treat patients diagnosed with Secondary hyperparathyroidism in Chronic Kidney Disease, compared to calcitriol and cinacalcet, might be dominant in China.
DEVELOPMENT OF AN INTELLIGENT SYSTEM FOR MANAGING EDGE COMPUTING
Authors: ХАКИМОВ А.А. , МУТХАННА А.С. , ВЫБОРНОВА А.И. 
Published: July 2021

Рассмотрена возможность размещения интернет-сервисов как на удаленных облаках, так и на распределенных граничных вычислительных системах. Предложена динамическая топология сети и размещения сервисов в граничных вычислительных системах с использованием генетического алгоритма для анализа и прогнозирования трафика сервисов. Представлены эффективные методы прогнозирования и предиктивной миграции сервисов для граничных вычислительных систем. Проанализированы проблемы построения высоконагруженных сетей и метода их решения путем выгрузки сервисов на граничные периферийные устройства. Предложена модель взаимодействий оператора сети и сторонних сервис-провайдеров для оптимальной выгрузки услуг. Показано, что эффективность сетевого оборудования может быть увеличена более чем на 30%.
The possibility of hosting Internet services both in remote clouds and in distributed edge computing systems is considered. Dynamic network topology and placement of services in edge computing systems using a genetic algorithm to analyze and predict service traffic are proposed. Effective methods for forecasting and predictive migration of services for edge computing systems are presented. An analysis of the problems of constructing high-load networks and the method of their solution by offloading services to edge peripheral devices are given. A model of interactions between the network operator and third-party service providers for optimal offloading of services is proposed. It is shown that the efficiency of network equipment can be increased by more than 30%.
Shari`ah, Brain Death, and Organ Transplantation
Authors: Grundmann Johannes 
Published: July 2021

Introduction
In the early 1980s, comprehensive developments in the public health system as well as markedly improved possibilities for organ transplantation due to the introduction of immune suppressants,2 namely, the artificial prevention of organ rejection, led to a sudden expansion of transplantation medicine in the Near and Middle East. Long-term artificial respiration, along with improved and expanded intensive care units, enabled respiration and circulation to be maintained despite the partial or complete loss of brain function. This, in turn, secured the necessary blood supply to the organs until they could be removed. Against this backdrop, a comprehensive process of discussion on the factual connections between postmortem organ transplantation and the criterion for determining brain death developed.
Efek Senyawa Timbal Asetat Terhadap Pertumbuhan Dan Kandungan Pigmen Klorofil Mikroalga Dunaliella sp.
Authors: Tamalonggehe Joshep , Kemer Kurniati , Paransa Darus Sa’adah J , Mantiri Desy MH , Kawung Nickson J , Undap Suzanne L 
Published: July 2021

Microalgae is one of the marine biota that has an important role in the waters because it acts as a supplier of food in the waters. Microalgae is a biological source that needs to be exploited because it is rich in essential compounds. Dunaliella sp. is one of the many micro algae used as research. Utilization of Dunaliella sp. quite diverse and has been marketed in developed countries because of its very attractive economic value. This study aims to determine the effects of lead acetate compounds on growth and content of chlorophyll pigments microalgae Dunaliella sp. The results obtained in this study are the lead acetate compounds can affect the number of cells in the growth of microalgae and analysis results obtained with a spectrophotometer showed that the extraction concentration of control day 5 (Exponential Phase) was higher than the concentration of 15 ppm and 25 ppm, whereas extraction on day 21 (Death Phase) concentration of 15 ppm was higher than 25 ppm.Keywords : Dunalella sp., Lead Acetate, Pigment chlorophyll RingkasanMikroalga adalah salah satu biota laut yang memiliki peran penting di perairan karena berfungsi sebagai pemasok makanan di perairan. Mikroalga adalah sumber biologis yang perlu dieksploitasi karena kaya akan senyawa esensial. Dunaliella sp. adalah salah satu dari banyak mikroalga yang digunakan sebagai penelitian. Pemanfaatan Dunaliella sp. cukup beragam dan telah dipasarkan di negara maju karena nilai ekonominya yang sangat menarik. Penelitian ini bertujuan untuk mengetahui efek senyawa timbal asetat terhadap pertumbuhan dan kandungan pigmen klorofil Dunaliella sp. Hasil yang diperoleh dalam penelitian ini adalah senyawa timbal asetat dapat mempengaruhi jumlah sel dalam pertumbuhan mikroalga, penurunan jumlah sel mengikuti konsentrasi timbal asetat yang diberikan dan hasil analisis yang diperoleh dengan spektrofotometer menunjukkan bahwa konsentrasi ekstraksi kontrol hari 5 (Fase Eksponensial) lebih tinggi daripada konsentrasi 15 ppm dan 25 ppm, sedangkan ekstraksi hari 21 (Fase Kematian) konsentrasi 15 ppm lebih tinggi dari 25 ppm.Kata kunci : Dunaliella sp., Timbal Asetat, Pigmen Klorofil
AKTIVITAS SENYAWA ANTIBAKTERI DAN ANTI-UV DARI Phyllidia varicosa (Cuvier, 1804) DAN BAKTERI SIMBIONNYA (NUDIBRANCHIA GASTROPODA) DARI PERAIRAN TANJUNG MANDOLANG, MINAHASA
Authors: Ukar Melania , Bara Robert A , Rumengan Inneke F M , Losung Fitje , Salaki Meiske , Warouw Veibe 
Published: July 2021

Phyllidia varicosa is an organism belongs to the order Nudibranchia, which is commonly known as a sea rabbit. This organism is able to synthesize secondary metabolites from food. The purpose of this study was to obtain P. varicosa extract and symbiotic bacterial extract from P. varicosa, then determine the antibacterial activity of P. varicosa extract and the symbionic bacteria extract against Escherichia coli DSM498, Bacillus megaterium DSM32T and anti-UV activity. P. varicose symbiotic bacterial were isolated and extracted. The results obtained 5 bacterial isolates. The results of antibacterial assay of isolates PhVa 1.1, PhVa 1.3, PhVa 2.1, PhVa 2.3 and PhVa 2.4 shown that these isolates have an antibacterial activity against E. coli DSM498 and B. megaterium DSM32T. Anti-UV assay results shown an absorption at UV-A with the highest value of 1.991 at λ 340 nm. Keywords: Nudibranchia, Phyllidia varicosa, Antibacterial, Anti-UV, Escherichia coli, Bacillus megaterium Abstrak Phyllidia varicosa merupakan organisme yang termasuk dalam ordo Nudibranchia, yang umumnya dikenal sebagai kelinci laut. Organisme ini mampu mensintesis metabolit sekunder dari bahan makanannya. Tujuan dari penelitian ini yaitu untuk mendapatkan ekstrak P. varicosa dan ekstrak bakteri simbion dari P. varicosa, kemudian mengamati aktivitas antibakteri dari ekstrak P. varicosa dan ekstrak bakteri simbionnya terhadap bakteri Escherichia coli DSM498 dan Bacillus megaterium DSM32T serta menguji aktivitas anti-UV. Bakteri yang bersimbion dengan P. varicosa diisolasi dan diekstraksi, lalu diuji bioaktivitas antibakteri dan diuji anti-UV terhadap ekstrak P. varicosa dan ekstrak bakteri simbionnya. Hasil akhir dari penelitian ini yaitu didapatkan 5 isolat bakteri. Hasil uji aktivitas antibakteri yaitu isolat PhVa 1.1, PhVa 1.3, PhVa 2.1, PhVa 2.3 dan PhVa 2.4 memiliki aktivitas antibakteri terhadap bakteri E. coli DSM498 dan B. megaterium DSM32T. Hasil uji anti-UV menunjukkan serapan pada UV-A dengan nilai tertinggi 1,991 pada λ 340 nm. Kata kunci: Nudibranchia, Phyllidia varicosa, Antibakteri, Anti-UV, Escherichia coli, Bacillus megaterium
KARBON PADA PADANG LAMUN DI PERAIRAN PULAU MANADO TUA
Authors: Maramis Mikhael A , Wagey Billy , Rumengan Antonius P , Sondak Calvyn F A , Opa Esry T , Kondoy Khristin F I 
Published: July 2021

Peningkatan emisi gas rumah kaca (GRK) antara lain karbondioksida (CO2) yang terjadi terus menerus mengakibatkan terjadinya pemanasan global dan perubahan iklim yang berdampak pada pola cuaca dan mempengaruhi kehidupan di bumi. Ekosistem padang lamun diketahui memiliki kemampun dalam menyerap karbondioksida dan menyimpannya dalam waktu yang lama. Telah dilakukan penelitian untuk mengetahui keanekaragaman jenis lamun, presentasi tutupan dan kandungan karbon pada padang lamun di perairan Pulau Manado Tua. Untuk mengetahui keanekaragaman jenis dilakukan pengamatan secara langsung pada setiap stasiun penelitian dan untuk mengetahui presentase tutupan lamun menggunakan metode line transek kuadran dengan mengadopsi Seagrass Watch dimana sampel lamun juga diperoleh dari line transek kuadran pada keseluruhan stasiun kemudian dianalisis selanjutnya menggunakan metode Loss on ignition (LOI). Didapatkan hasil penelitian pada keseluruhan stasiun indeks keanekaragaman H’ 1 kategori sedang dengan presentase penutupan dan status kondisi pada stasiun negri 36% kurang kaya/kurang sehat, stasiun pangalingan 69% kaya/sehat, stasiun papindang 51% kurang kaya/kurang sehat : kandungan karbon pada keseluruhan stasiun yang didapat sebesar 222,85gC Kata Kunci : Keanekaragaman Lamun, Presentase Penutupan, Kandungan Karbon, Line Transek, Kuadran, LOI (Loss On Ignition), Pulau Manado Tua.
ANALISIS STRUKTUR KOMUNITAS MANGROVE DI KAWASAN SEKITAR PT. CONCH KABUPATEN BOLAANG MONGONDOW
Authors: Pandeirot George L , Rumengan Antonius P , Paruntu Carolus P , Darwisito Surya , Ompi Medy , Wantasen Adnan S 
Published: July 2021

This research was conducted for four months of April-July 2020. The purpose of this study was to determine species density, species relative density, species frequency, species relative frequency, species cover, species relative cover, index of the importance of mangrove species in the area around PT. Conch Lolak District, Bolaang Mongondow Regency, North Sulawesi Province. This research was conducted for four months of April-July 2020. The method used was a quadratic plot of 6 stations. Data collection at each station was made with a plot size of 10 × 10 m2 to measure the diameter of a tree at breast height (DBH), which has a minimum trunk circumference of 16 cm. The results showed that there were five types of mangroves, namely R. apiculata, R. mucronata, B. gymnorhiza, S. alba, and X. granatum. The highest relative density of species at station 2, namely R. mucronate 62.96%, while the lowest value at station 3, namely R. mucronata 8.77%, the highest relative frequency value at station 4, namely R. mucronata 33.33%, whereas the lowest value was at station 5, namely B. gymnorhiza 25.00%, the highest relative closure value was at station 5, namely R. mucronata 30.91%, while the lowest was at station 2, namely R. apiculata 12.88%, and the important value index the highest was at station 3, namely R. apiculata 138.09% and the lowest value was at station 5, namely X. granatum 35.05%.Kata Kunci: Mangrove, Structure in areas around PT. Conch. Conch, Rhizopora Abstrak Penelitian ini dilakukan selama 4 bulan April-Juli 2020. Tujuan penelitian ini adalah untuk mengetahui kerapatan jenis, kerapatan relatif jenis, frekuensi jenis, frekuensi relatif jenis, penutupan jenis, penutupan relatif jenis, indeks nilai penting jenis mangrove yang ada di kawasan sekitar PT. Conch Kecamatan Lolak, Kabupaten Bolaang Mongondow, Provinsi Sulawawesi Utara. Penelitian ini dilakukan selama 4 bulan April-Juli 2020. Metode yang dipakai adalah plot kuadrat sebanyak 6 stasiun. Pengambilan data pada setiap stasiun dibuat plot dengan ukuran 10 × 10 m2 untuk mengukur diameter pohon setinggi dada (DBH) yang memiliki lingkar batang minimal 16 cm. Hasil penelitian menunjukkan bahwa ada 5 jenis mangrove yaitu R. apiculata, R. mucronata, B. gymnorhiza, S. alba dan X. granatum. Kerapatan relatif jenis tertinggi pada stasiun 2, yaitu R. mucronata 62,96%, sedangkan nilai terendah pada stasiun 3, yaitu R. mucronata 8,77%, nilai Frekuensi relatif jenis tertingi pada stasiun 4, yaitu R. mucronata 33.33%, sedangkan nilai terendah pada stasiun 5, yaitu B. gymnorhiza 25.00%, nilai Penutupan relatif jenis tertinggi pada stasiun 5, yaitu R. mucronata 30,91%, sedangkan terendah pada stasiun 2, yaitu R. apiculata 12,88%, dan Indeks nilai penting tertinggi pada stasiun 3, yaitu R. apiculata 138,09% dan nilai terendah pada stasiun 5, yaitu X. granatum 35,05%.Kata Kunci: Mangrove, kawasan sekitar PT. Conch, Rhizopora
PENGARUH LOGAM BERAT TIMBAL TERHADAP PERTUMBUHAN ALGA Halimeda opuntia YANG DIKULTUR DALAM WADAH TERKONTROL
Authors: Sugiarto Kristi Aji , Mantiri Desy MH , Kawung Nickson J , Rompas Rizald M , Tilaar Sandra O , Wantasen Adnan 
Published: July 2021

Heavy metal is a very dangerous pollutant waste for it cannot be destroyed (non-degradable) and over time it will accumulate in the ocean. This study aims to determine the lead content in sediment, water and algal thallus as well as to determine the algae growth that has been treated with lead. The research method used was a completely randomized design (CRD) which consisted of 3 treatments, using different treatments for each sample. The highest metal content obtained in the sediment was 5,124 ppm, in the water was 0.120 ppm, and in the algae thallus was 4,816 ppm respectively. The results showed that Halimeda opuntia algae can grow even in an environment contaminated with lead heavy metal and can become a bioremediation agent by absorbing lead heavy metal. Keywords: Halimeda opuntia, Lead Heavy Metal, Algae Culture, Bioremediation Logam berat merupakan salah satu limbah pencemar yang sangat berbahaya karena tidak dapat dihancurkan (non degradable) dan dapat terakumulasi di perairan laut. Penelitian ini bertujuan untuk mengetahui kandungan timbal pada sedimen, air dan thallus alga yang dikultur serta mengetahui pertumbuhan alga yang telah diberi perlakuan timbal. Metode penelitian mengunakan metode Rancangan Acak Lengkap (RAL) yang terdiri dari 3 perlakuan, dengan menggunakan perlakuan yang berbeda pada tiap sampel dan kontrol. Kandungan logam tertinggi yang didapatkan pada sedimen yaitu sebesar 5,124 ppm, pada air sebesar 0,120 ppm, dan pada thallus alga sebesar 4,816 ppm. Hasil yang diperoleh yaitu alga Halimeda opuntia dapat bertumbuh walaupun dalam lingkungan yang tercemar logam berat timbal serta mampu menjadi agen bioremediasi dengan menyerap logam berat timbal. Kata kunci: Halimeda opuntia, Logam BeratTimbal, Kultur Alga, Bioremediasi
ESTIMATION OF ADJUSTING INDICATORS OF DIESEL UNDER HIGH-TEMPERATURE EXPOSURE TO DT
Authors: ПЛОТНИКОВ С.А. , КАРТАШЕВИЧ А.Н. , СМОЛЬНИКОВ М.В. , ШИПИН А.И. 
Published: July 2021

Проблема и цель. Цель исследований – определение оптимальных регулировочных значений топливоподающей аппаратуры (ТПА) дизельного двигателя Д-245.5S2, широко применяемого в народном хозяйстве, при использовании многокомпонентного биотоплива. Объекты и методы. Объект исследований – экспериментальная установка, включающая дизель Д-245.5S2, моторный стенд RAPIDO SAK N670, разработанные составы многокомпонентных биотоплив. Содержание стендовых испытаний определялось ГОСТ 18509-88. Исследовалась работа двигателя на чистом дизельном топливе (ДТ) и многокомпонентных биотопливных композициях (МКБТ) с присутствием 15 % и 25 % этанола и рапсового масла, каждого. Методика испытаний включала снятие регулировочной характеристики. Меняли установочный угол подачи топлива в номинальном режиме работы объекта исследований. Не менее, чем при семи значениях угла фиксировались выходные показатели. Ход экспериментов. Значения дымности и токсичности, мощности и экономичности фиксировались, данные эксперимента и последующих расчетов наносились на график. Результаты и выводы. В результате анализа данных были выявлены наиболее приемлемые, с экономической точки зрения, интервалы изменения регулировок системы впрыскивания топлива. изменения токсичности и дымности отработавших газов при разных составах топлива.
Problem and the purpose. The purpose of researches - defnition of optimum adjusting values submitting fuel equipments (SFE) the diesel engine D-245.5S2 widely applied in a national economy, at application of multicomponent biofuels. Objects and methods. Object of researches - the experimental installation including diesel engine D-245.5S2, electrobrake stand RAPIDO SAK N670 with балансирной by the balance pendular machine, new structures fuels. The contents of bench tests was determined GOST 18509-88. Job of the engine on pure diesel fuel(DF) and multicomponent biofuel compositions (MCBT) with presence of 15% and 25% of ethanol and rape seed oils, everyone was investigated. The technique of tests included removal of the adjusting characteristic. Changed an adjusting corner of submission of fuel in a nominal operating mode of object of researches. Not less, than at seven values of a corner target parameters were fxed. Course of experiments. Values smokiness and toxicity, power and proftability were fxed, data of experiment and the subsequent calculations were rendered on the schedule. Results and conclusions. As a result of the analysis of data the most comprehensible have been revealed, from the economic point of view, intervals of change of adjustments of system of injection of fuel. Changes of toxicity and smokiness the fulflled gases at diferent structures of fuel.
SIMULAÇÃO DO PROCESSO DE PRODUÇÃO DE INSERTO COM O SOFTWARE ARENA
Authors: Ramos Chiconelli Murilo , Belga Rodrigues Emmanuel , Belga Rodrigues Maria Eduarda , Mendes Alves Matheus Hernesto , Bittencourt Nazare Tiago 
Published: July 2021

No presente artigo foi utilizado o software arena para realizar uma simulação do processo de produção de mancais em uma fábrica de usinagem, localizada na cidade de Cataguases, interior de Minas Gerais, cujo o objetivo foi identificar possíveis melhorias e eliminar os gargalos encontrados. Deste modo, foram coletados os tempos médios de 3 operações antes do processo de montagem, adquiridos de um lote de 25 insertos. Assim, foi observado por meio da simulação realizada, que o tempo de operação sofreu uma redução de 29,14% utilizando o método de melhoria proposto.
PENDAMPINGAN PERENCANAAN PEMBANGUNAN PELEBARAN JEMBATAN BIBIS LUHUR RW 022 NUSUKAN BANJARSARI SURAKARTA
Authors: Reki Arbianto  , Yuono Teguh , Hartanto Tri , Amhudo Rasyiid Lathiif , Gunarso Gunarso 
Published: July 2021

Bibis Luhur merupakan salah satu kampung di kelurahan Nusukan, kecamatan Banjarsari, kota Surakarta. Kampung Bibis Luhur terdapat sebuah jembatan tepatnya di RW 022 yang menghubungkan antar RW. Kondisi jembatan sekarang ini dirasakan sudah sempit karena pertumbuhan jumlah kendaraan dan lalu lintas harian yang melaluinya. Oleh sebab itu dengan dorongan dari masyarakat warga RW 022 maka jembatan ini akan diperlebar, untuk menunjang aktifitas warga sekitar. Tahapan yang dilakukan pada pendampingan kali ini dibagi menjadi 2 tahap yaitu tahap persiapan dan tahap pelaksanaan. Pada kegiatan persiapan dilakukan diskusi dan koordinasi dengan perangkat kampung Bibis Luhur RW 022 dan warga sekitar guna memberikan masukan yang bersifat membangun untuk kegiatan ini sedangkan pada tahap pelaksanaan dilakukan pengukuran sampai dengan penggambaran detail desain guna memperkirakan besarnya anggaran biaya untuk pekerjaan pembangunan pelebaran jembatan Bibis Luhur RW 022, Kel. Nusukan, Kec. Banjarsari Surakarta. Berdasarkan hasil pendampingan dihasilkan gambar struktur dan Rencana Anggaran Biaya untuk pembangunan pelebaran jembatan Bibis Luhur RW 022, Kel. Nusukan, Kecamatan Surakarta adalah sebesar Rp 20.300.000,00. Hasil detail desain dan analisa biaya tersebut untuk selanjutnya dapat digunakan sebagai dasar dalam pelaksanaan pekerjaan konstruksi.