bluuebunny/crossref_metadata_2025_split huggingface dataset:
New-generation osteoplastic materials based on biological and synthetic matrices
Authors: Lykoshin D. D. , Zaitsev V. V. , Kostromina M. A. , Esipov R. S. 
Published: March 2021

Objectives. The purpose of this analytical review is to evaluate the market for osteoplastic materials and surgical implants, as well as study the features of new-generation materials and the results of clinical applications.Methods. This review summarizes the volumes of research articles presented in the electronic database PubMed and eLIBRARY. A total of 129 scientific articles related to biological systems, calcium phosphate, polymer, and biocomposite matrices as carriers of pharmaceutical substances, primary recombinant protein osteoinductors, antibiotics, and biologically active chemical reagents were analyzed and summarized. The search depth was 10 years.Results. Demineralized bone matrix constitutes 26% of all types of osteoplastic matrices used globally in surgical osteology, which includes neurosurgery, traumatology and orthopedics, dentistry, and maxillofacial and pediatric surgery. Among the matrices, polymer and biocomposite matrices are outstanding. Special attention is paid to the possibility of immobilizing osteogenic factors and target pharmaceutical substances on the scaffold material to achieve controlled and prolonged release at the site of surgical implantation. Polymeric and biocomposite materials can retard the release of pharmaceutical substances at the implantation site, promoting a decrease in the toxicity and an improvement in the therapeutic effect. The use of composite scaffolds of different compositions in vivo results in high osteogenesis, promotes the initialization of biomineralization, and enables the tuning of the degradation rate of the material.Conclusions. Osteoplastic materials of various compositions in combination with drugs showed accelerated regeneration and mineralization of bone tissue in vivo, excluding systemic side reactions. Furthermore, although some materials have already been registered as commercial drugs, a plethora of unresolved problems remain. Due to the limited clinical studies of materials for use on humans, there is still an insufficient understanding of the toxicity of materials, time of their resorption, speed of drug delivery, and the possible long-term adverse effects of using implants of different compositions.
Chemical and technological aspects of increasing the functional characteristics of hard piezoceramics
Authors: Talanov M. V. , Marakhovskiy M. A. 
Published: March 2021

Objectives. Ferroelectrically hard piezoelectric ceramics are in demand for high-power applications in piezotransformers, ultrasonic emitters, and piezo motors, which requires a combination of high piezoelectric characteristics and mechanical quality factors in it. The aim of this research was to reveal the main regularities in the microstructure and functional characteristic formation of ferroelectrically hard piezoceramics based on two widespread chemical systems, Pb(ZrxTi1-x)O3 and (Na1-xKx)NbO3, through various technological modes of production. In this study, two fundamentally different technological ways of forming a dense microstructure on the example of above systems have been employed to obtain the best set of dielectric, piezoelectric, and mechanical parameters for practical applications. In the case of lead-containing ceramics, various sintering technologies have been used, including conventional ceramic, hot pressing, and spark plasma sintering.Methods. The microstructure of the piezoelectric ceramics was investigated using electron microscopy, and the functional characteristics were assessed in terms of mechanical and piezoelectric properties. The density values were determined by hydrostatic weighing in octane, the relative dielectric permittivity was measured using an LCR meter, and the values of the piezoelectric coefficient and mechanical quality factor were gathered using the resonance–antiresonance method.Results. This research has identified that spark plasma sintering technology makes it possible to obtain high-density samples, which contain a homogeneous microstructure and double the figure-of-merit values, for use in high-power piezoelectric devices that operate at piezoresonance frequencies. It also found that the addition of a small amount of CuNb2O6 (x = 0.025) to lead-free solid solutions leads to the formation of a liquid phase during sintering, thereby creating a compacted microstructure with relative density values (96%) that have practical limitations in conventional ceramic technology. An increase in both the piezoelectric and mechanical properties, which leads to a twofold increase in the values of the quality indicator, was also observed.Conclusions. It is possible to increase, and even to double, the functional characteristics of both lead-containing and lead-free ferroelectrically hard piezoceramics by varying the technology used in the manufacturing process. By using spark plasma sintering technology with lead-containing ceramics, it is possible to reduce the optimum sintering temperature by 200 °C and the sintering time by more than 20 times, thus reducing production costs.
Liquid mixtures separation and heat consumption in the process of distillation
Authors: Zakharov M. K. , Egorov A. V. , Podmetenny A. A. 
Published: March 2021

Objectives. The aim of this study is to investigate different distillation modes of a binary ideal mixture and determine how various factors affect heat consumption in the column boilers. In addition, it intends to assess the difficulty of separating mixtures. Our research is based on analyzing the characteristics of vapor-liquid equilibrium.Methods. To conduct our study, we used a graphic-analytical tool to calculate the distillation process of a binary mixture and mathematical models based on the Aspen Plus software package along with DSTWU, RadFrac, and the Sensitivity module. We also used the Peng-Robinson equation (PENG-ROB) to determine the liquid-vapor equilibrium.Results. We employed the graphical method and mathematical models to obtain the operation parameters of two column variants for the distillation of binary ideal benzene-toluene mixtures. In each variant the initial mixture contained the same amount of the low- and high-boiling component. The number of plates in the column sections, reflux ratio, energy consumption, and indicators of internal energy saving were determined.Conclusions. Study results show that using the coefficient of the component distribution between the vapor and liquid phases is a promising method for preliminary assessments of the separation difficulty and measurements of the expected heat consumption in the boilers of columns. Comparison studies showed that the heat consumption in the boiler decreases as the internal energy saving in the columns increases.
Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC
Authors: Shchekoldina Z. N. , Bogolyubov A. A. , Zakharov A. Yu. , Bulgakov B. A. , Babkin A. V. , Kepman A. V. 
Published: March 2021

Objectives. Determination of target products and byproducts is necessary for the quality control of phthalonitrile monomer synthesis as well as production scaling and performing related kinetic studies. High-performance liquid chromatography (HPLC) is a simple and affordable method for quantitative chemical analysis, which also verifies the quality of raw materials. The objective of this study was to develop an HPLC technique for determining the composition of the reaction mixture in the synthesis of 1,3-bis(3,4-dicyanophenoxy)benzene (DPB).Methods. Reversed-phase HPLC was used to quantitatively analyze the reaction mixture.Results. A simple and rapid method for the quantitative HPLC analysis of phthalonitrile monomers and their mixtures with reagents was developed. Reaction times and the accumulation of byproducts were also studied.Conclusions. The successful performance of the developed technique allows us to recommend it for practical applications. The results obtained for reactors of different sizes have good convergence, and DPB synthesis was successfully scaled up to intermediate scale equipment.
Analysis of Factors Affecting Trust on the Use of FinTech (P2P Lending) in Indonesia
Authors: Pratama Jimmy 
Published: March 2021

Since 2016 the P2P Lending industry has begun to develop in Indonesia. Peer to Peer Lending (P2P Lending) is a new alternative to getting funds in the form of money loans to individuals or investors. Fintech P2P Lending provides convenience through a simple and fast service. Its features can be accessed by anyone, anytime, anywhere. On the other hand, investors or lenders have investment alternatives with attractive returns. So that it quickly spread to all segments of Indonesian society. The purpose of this research is to analyze what factors can influence trust in using of P2P Lending in Indonesia. The difference between this study and previous research is that there is no research that focuses on trust in the use of FinTech, especially P2P Lending in Indonesia. This research is a type of quantitative research that used is primary data obtained by distributing questionnaires directly to Indonesians. The samples taken by Simple Random Sampling Technique and obtained 400 respondents as user fintech. And the statistical analysis used in this study is multiple regression and using SPSS 23 program. Based on the result, this study showed that the variable of structural assurance, easy of use, and brand image were significant on trust in using FinTech, meanwhile the variable of integrity was not significant on trust in using FinTech.
“Russian libraries in Germany” – The essays in history
Authors: Ermolaeva M. A. 
Published: March 2021

Review of the collection of works prepared by Gottfried Kratz (Gottfried Kratz. Russische Biblioteken in Deutschland. – Berlin : Peter Lang, 2020. – 231 s. (Arbeiten und Bibliographen zum Buch – und Bibliothekswesen. 17).The book in German comprises the papers by German and Russian researchers on public, academic, military and church libraries in the mid-19th century and up to present. The reviewer focuses on the works matching the profile of the “Scientific and Technical Libraries” journal. The presented works are based on vast archival materials and expand the knowledge of Russian-German library relationships within the mentioned historical period. The researchers of Russian diaspora abroad, book and library historians will make the readership of the book.
Mobile Website User Experience (UX) Evaluation on Indonesia's Online Marketplace
Authors: Pratama Khosyi Yoga , Purnama James , Ipung Heru Purnomo 
Published: March 2021

Internet economy is growing in Indonesia, and so is the smartphone usage. The popularity of online marketplace is getting bigger by the day yet the market is not utilized as best as it could. A lot of new smartphone user may not be familiar with the concept of mobile application, yet they browse for products to purchase using their mobile web browser. Therefore a mobile website User Experience (UX) evaluation on online marketplace in Indonesia is needed. By using User Experience Questionnaire (UEQ), this research hopes to evaluate which aspect of a marketplace’s mobile website is looked for by its users. An interview is conducted to 30 people to simulate shopping experience on Tokopedia and Bukalapak using a mobile web browser. The result shows that users prefers shopping without having to register, thus making online shopping quick and easy. In addition, user prefers to have all information they need regarding a product in one page rather than having to perform many action to reveal more information.
Graphene Oxide and Reduced Graphene Oxide Exhibit Cardiotoxicity Through the Regulation of Lipid Peroxidation, Oxidative Stress, and Mitochondrial Dysfunction
Authors: Zhang Jian , Cao Hong-Yan , Wang Ji-Qun , Wu Guo-Dong , Wang Lin 
Published: March 2021

ObjectiveGraphene has been widely used for various biological and biomedical applications due to its unique physiochemical properties. This study aimed to evaluate the cardiotoxicity of graphene oxide (GO) and reduced GO (rGO)in vitroandin vivo, as well as to investigate the underlying toxicity mechanisms.MethodsGO was reduced by gamma irradiation to prepare rGO and then characterized by UV/visible light absorption spectroscopy. Rat myocardial cells (H9C2) were exposed to GO or rGO with different absorbed radiation doses. Thein vitrocytotoxicity was evaluated by MTT assay, cell apoptosis assay, and lactate dehydrogenase (LDH) activity assay. The effects of GO and rGO on oxidative damage and mitochondrial membrane potential were also explored in H9C2 cells. Forin vivoexperiments, mice were injected with GO or rGO. The histopathological changes of heart tissues, as well as myocardial enzyme activity and lipid peroxidation indicators in heart tissues were further investigated.ResultsrGO was developed from GO following different doses of gamma irradiation.In vitroexperiments in H9C2 cells showed that compared with control cells, both GO and rGO treatment inhibited cell viability, promoted cell apoptosis, and elevated the LDH release. With the increasing radiation absorbed dose, the cytotoxicity of rGO gradually increased. Notably, GO or rGO treatment increased the content of ROS and reduced the mitochondrial membrane potential in H9C2 cells.In vivoexperiments also revealed that GO or rGO treatment damaged the myocardial tissues and changed the activities of several myocardial enzymes and the lipid peroxidation indicators in the myocardial tissues.ConclusionGO exhibited a lower cardiotoxicity than rGO due to the structure difference, and the cardiotoxicity of GO and rGO might be mediated by lipid peroxidation, oxidative stress, and mitochondrial dysfunction.
Prognostic Signature for Lung Adenocarcinoma Patients Based on Cell-Cycle-Related Genes
Authors: Jiang Wei , Xu Jiameng , Liao Zirui , Li Guangbin , Zhang Chengpeng , Feng Yu 
Published: March 2021

ObjectiveTo screen lung adenocarcinoma (LUAC)-specific cell-cycle-related genes (CCRGs) and develop a prognostic signature for patients with LUAC.MethodsThe GSE68465, GSE42127, and GSE30219 data sets were downloaded from the GEO database. Single-sample gene set enrichment analysis was used to calculate the cell cycle enrichment of each sample in GSE68465 to identify CCRGs in LUAC. The differential CCRGs compared with LUAC data from The Cancer Genome Atlas were determined. The genetic data from GSE68465 were divided into an internal training group and a test group at a ratio of 1:1, and GSE42127 and GSE30219 were defined as external test groups. In addition, we combined LASSO (least absolute shrinkage and selection operator) and Cox regression analysis with the clinical information of the internal training group to construct a CCRG risk scoring model. Samples were divided into high- and low-risk groups according to the resulting risk values, and internal and external test sets were used to prove the validity of the signature. A nomogram evaluation model was used to predict prognosis. The CPTAC and HPA databases were chosen to verify the protein expression of CCRGs.ResultsWe identified 10 LUAC-specific CCRGs (PKMYT1, ETF1, ECT2, BUB1B, RECQL4, TFRC, COCH, TUBB2B, PITX1, and CDC6) and constructed a model using the internal training group. Based on this model, LUAC patients were divided into high- and low-risk groups for further validation. Time-dependent receiver operating characteristic and Cox regression analyses suggested that the signature could precisely predict the prognosis of LUAC patients. Results obtained with CPTAC, HPA, and IHC supported significant dysregulation of these CCRGs in LUAC tissues.ConclusionThis prognostic prediction signature based on CCRGs could help to evaluate the prognosis of LUAC patients. The 10 LUAC-specific CCRGs could be used as prognostic markers of LUAC.
Novel Chromosome-Borne Accessory Genetic Elements Carrying Multiple Antibiotic Resistance Genes in Pseudomonas aeruginosa
Authors: Yu Ting , Yang Huiying , Li Jun , Chen Fangzhou , Hu Lingfei , Jing Ying , Luo Xinhua , Yin Zhe , Zou Mingxiang , Zhou Dongsheng 
Published: March 2021

Pseudomonas aeruginosa is noted for its intrinsic antibiotic resistance and capacity of acquiring additional resistance genes. In this study, the genomes of nine clinical P. aeruginosa isolates were fully sequenced. An extensive genetic comparison was applied to 18 P. aeruginosa accessory genetic elements (AGEs; 13 of them were sequenced in this study and located within P. aeruginosa chromosomes) that were divided into four groups: five related integrative and conjugative elements (ICEs), four related integrative and mobilizable elements (IMEs), five related unit transposons, and two related IMEs and their two derivatives. At least 45 resistance genes, involved in resistance to 10 different categories of antibiotics and heavy metals, were identified from these 18 AGEs. A total of 10 β-lactamase genes were identified from 10 AGEs sequenced herein, and nine of them were captured within class 1 integrons, which were further integrated into ICEs and IMEs with intercellular mobility, and also unit transposons with intracellular mobility. Through this study, we identified for the first time 20 novel MGEs, including four ICEs Tn6584, Tn6585, Tn6586, and Tn6587; three IMEs Tn6853, Tn6854, and Tn6878; five unit transposons Tn6846, Tn6847, Tn6848, Tn6849, and Tn6883; and eight integrons In1795, In1778, In1820, In1784, In1775, In1774, In1789, and In1799. This was also the first report of two resistance gene variants blaCARB-53 and catB3s, and a novel ST3405 isolate of P. aeruginosa. The data presented here denoted that complex transposition and homologous recombination promoted the assembly and integration of AGEs with mosaic structures into P. aeruginosa chromosomes.
Harnessing Big Data to Optimize an Algorithm for Rapid Diagnosis of Pulmonary Tuberculosis in a Real-World Setting
Authors: Peng Jing , Song Juan , Wang Feng , Zuo Peng , Lu Yanjun , Liu Weiyong , Tian Lei , Chen Zhongju , Zhu Yaowu , Wang Xiong , Shen Na , Wang Xu , Wu Shiji , Yu Qin , Vallance Bruce A. , Jacobson Kevan , Sun Ziyong , Yu Hong Bing 
Published: March 2021

BackgroundThe prompt diagnosis of pulmonary tuberculosis (PTB) remains a challenge in clinical practice. The present study aimed to optimize an algorithm for rapid diagnosis of PTB in a real-world setting.Methods28,171 adult inpatients suspected of having PTB in China were retrospectively analyzed. Bronchoalveolar lavage fluid (BALF) and/or sputum were used for acid-fast bacilli (AFB) smear, Xpert MTB/RIF (Xpert), and culture. A positive mycobacterial culture was used as the reference standard. Peripheral blood mononuclear cells (PBMC) were used for T-SPOT.TB. We analyzed specimen types’ effect on these assays’ performance, determined the number of smears for diagnosing PTB, and evaluated the ability of these assays performed alone, or in combination, to diagnose PTB and nontuberculous mycobacteria (NTM) infections.ResultsSputum and BALF showed moderate to substantial consistency when they were used for AFB smear or Xpert, with a higher positive detection rate by BALF. 3-4 smears had a higher sensitivity than 1-2 smears. Moreover, simultaneous combination of AFB and Xpert correctly identified 44/51 of AFB+/Xpert+ and 6/7 of AFB+/Xpert- cases as PTB and NTM, respectively. Lastly, when combined with AFB/Xpert sequentially, T-SPOT showed limited roles in patients that were either AFB+ or Xpert+. However, T-SPOTMDC (manufacturer-defined cut-off) showed a high negative predicative value (99.1%) and suboptimal sensitivity (74.4%), and TBAg/PHA (ratio of Mycobacterium tuberculosis-specific antigens to phytohaemagglutinin spot-forming cells, which is a modified method calculating T-SPOT.TB assay results) ≥0.3 demonstrated a high specificity (95.7%) and a relatively low sensitivity (16.3%) in AFB-/Xpert- patients.ConclusionsConcurrently performing AFB smear (at least 3 smears) and Xpert on sputum and/or BALF could aid in rapid diagnosis of PTB and NTM infections in a real-world high-burden setting. If available, BALF is preferred for both AFB smear and Xpert. Expanding this algorithm, PBMC T-SPOTMDC and TBAg/PHA ratios have a supplementary role for PTB diagnosis in AFB-/Xpert- patients (moderately ruling out PTB and ruling in PTB, respectively). Our findings may also inform policy makers’ decisions regarding prevention and control of TB in a high burden setting.
Pediococcus acidilactici Strains Improve Constipation Symptoms and Regulate Intestinal Flora in Mice
Authors: Qiao Yiteng , Qiu Zhichang , Tian Fengwei , Yu Leilei , Zhao Jianxin , Zhang Hao , Zhai Qixiao , Chen Wei 
Published: March 2021

Constipation is a prevalent gastrointestinal disorder that seriously reduces the quality of life. Clinical studies have shown that a great change or severe imbalance occurs in the intestinal microbiota of people with constipation. This study explored whether bacteriocin-producing and non-bacteriocin-producing Pediococcus acidilactici strains resulted in differences in the alleviation of constipation and changes in the fecal flora in BALB/c mice. The constipation-related indicators, gastrointestinal regulatory peptides and gut microbiota were identified to evaluate their alleviating effects and underlying mechanisms. The time to the first black-stool defecation and the gastrointestinal transit rate in constipated mice were found to be somewhat improved by four P. acidilactici strains (P &gt; 0.05). Moreover, there were significant differences in the level of most gastrointestinal regulatory peptides in the serum, as well as in the composition and abundance of intestinal microbiota in different groups (P &lt; 0.05). At the phylum level, the relative abundance of Firmicutes was significantly increased, but those of Bacteroidetes and Proteobacteria were significantly reduced after the administration of four P. acidilactici strains for 14 d (P &lt; 0.05). The levels of Bacteroides and genera from Enterobacteriaceae were significantly decreased, whereas Bifidobacterium and Lactobacillus were upregulated when bacteriocin-producing P. acidilactici CCFM18 and CCFM28 strains were provided in the diet (P &lt; 0.05). The results indicated that although constipation-related symptoms were alleviated to only a limited degree, the administration of four P. acidilactici strains effectively regulated the gut flora and provided a potential health benefit to the host, especially the bacteriocin-producing P. acidilactici strains.