bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scheduling of waterways with tide and passing box
Authors: Nehrke Lara , Schulz Arne 
Published: November 2021

AbstractDue to the increasing amount of goods transported by vessels and the resulting increased size of the vessels, waterway scheduling becomes a challenging task. Waterways can often only be expanded with enormous costs and environmental damage. Therefore, this paper investigates a scheduling problem on a restricted waterway. Wide vessels are only allowed to pass in a passing box and vessels with deep draught can only pass the waterway in a time window around high tide. We present a mixed‐integer program (MIP) for the problem setting and develop techniques which allow us to fix variables and reduce the number of variables and constraints of the model. The resulting model formulations are evaluated in a comprehensive computational study on a real‐world setting at the river Elbe next to Hamburg (Germany).
Development and acceptability of a decision aid for chronic insomnia considering discontinuation of benzodiazepine hypnotics
Authors: Aoki Yumi , Takaesu Yoshikazu , Suzuki Masahiro , Okajima Isa , Takeshima Masahiro , Shimura Akiyoshi , Utsumi Tomohiro , Kotorii Nozomu , Yamashita Hidehisa , Kuriyama Kenichi , Watanabe Norio , Mishima Kazuo 
Published: November 2021

AbstractAimTo describe the development and acceptability of a decision aid (DA) for chronic insomnia considering discontinuation of benzodiazepine (BZD) and benzodiazepine receptor agonist (BZRA) hypnotics, and if discontinuing, tapering with or without cognitive behavioral therapy for insomnia (CBT‐I).MethodsWe reviewed relevant literature describing chronic insomnia to identify options. We used the results of the systematic review and meta‐analysis conducted previously to determine the related outcomes of two options: discontinuation of BZD/BZRA hypnotics by gradual tapering alone and discontinuation of BZD/BZRA hypnotics by gradual tapering with CBT‐I. We then developed a prototype of DA following the International Patient Decision Aid Standards. A mixed methods survey was conducted to assess the acceptability among patients and healthcare providers.ResultsThe prototype consisted of a description of insomnia, options of continuing or discontinuing BZD/BRZA hypnotics (if discontinuing, the options of tapering hypnotics with or without CBT‐I), pros and cons of each option, and a value clarification exercise. Patients (n = 24) reported that the DA had acceptable language (79%), adequate information (71%), and well‐balanced presentation (91%). Healthcare providers (n = 20) also provided favorable feedback.ConclusionWe developed a DA for chronic insomnia considering discontinuation of BZD/BRZA hypnotics, which was acceptable for stakeholders. The developed DA was designed to support patients and healthcare providers to make a decision about whether to discontinue BZD/BRZA hypnotics.
Computational Pharmacokinetics Report, ADMET Study and Conceptual DFT‐Based Estimation of the Chemical Reactivity Properties of Marine Cyclopeptides
Authors: Flores‐Holguín Norma , Frau Juan , Glossman‐Mitnik Daniel 
Published: November 2021

AbstractHomophymines A–E and A1–E1 are bioactive natural cyclodepsipeptides with a complex molecular architecture. These molecules could have a potential use as antimicrobial, antiviral, and anticancer substances. We have carried out a computational study of the properties of this family of marine peptides using a CDFT‐based Computational Peptidology (CDFT‐CP) methodology that results from the combination of the chemical reactivity descriptors that arise from conceptual Density Functional Theory (CDFT) together with cheminformatics tools. The latter can be used to estimate the associated physicochemical parameters and to improve the process of virtual screening through a similarity search. Using this approach, the ability of the peptides to behave as a potentially useful drugs can be investigated. An analysis of their bioactivity and pharmacokinetics indices related to the ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) features has also been carried out.
Using fractional polynomials and restricted cubic splines to model non‐proportional hazards or time‐varying covariate effects in the Cox regression model
Authors: Austin Peter C. , Fang Jiming , Lee Douglas S. 
Published: November 2021

AbstractThe Cox proportional hazards model is used extensively in clinical and epidemiological research. A key assumption of this model is that of proportional hazards. A variable satisfies the proportional hazards assumption if the effect of that variable on the hazard function is constant over time. When the proportional hazards assumption is violated for a given variable, a common approach is to modify the model so that the regression coefficient associated with the given variable is assumed to be a linear function of time (or of log‐time), rather than being constant or fixed. However, this is an unnecessarily restrictive assumption. We describe two different methods to allow a regression coefficient, and thus the hazard ratio, in a Cox model to vary as a flexible function of time. These methods use either fractional polynomials or restricted cubic splines to model the log‐hazard ratio as a function of time. We illustrate the utility of these methods using data on 12 705 patients who presented to a hospital emergency department with a primary diagnosis of heart failure. We used a Cox model to assess the association between elevated cardiac troponin at presentation and the hazard of death after adjustment for an extensive set of covariates. SAS code for implementing the restricted cubic spline approach is provided, while an existing Stata function allows for the use of fractional polynomials.
Doppler evaluation of normal and abnormal placenta
Authors: Hernandez‐Andrade E. , Huntley E. S. , Bartal M. F. , Soto‐Torres E. E. , Tirosh D. , Jaiman S. , Johnson A. 
Published: November 2021

ABSTRACTDoppler techniques are needed for the evaluation of the intraplacental circulation and can be of great value in the diagnosis of placental anomalies. Highly sensitive Doppler techniques can differentiate between the maternal (spiral arteries) and fetal (intraplacental branches of the umbilical artery) components of the placental circulation and assist in the evaluation of the placental functional units. A reduced number of placental functional units can be associated with obstetric complications, such as fetal growth restriction. Doppler techniques can also provide information on decidual vessels and blood movement. Abnormal decidual circulation increases the risk of placenta accreta.Doppler evaluation of the placenta greatly contributes to the diagnosis and clinical management of placenta accreta, vasa previa, placental infarcts, placental infarction hematoma, maternal floor infarction, massive perivillous fibrin deposition and placental tumors. However, it has a limited role in the diagnosis and clinical management of placental abruption, placental hematomas, placental mesenchymal dysplasia and mapping of placental anastomoses in monochorionic twin pregnancies. © 2021 International Society of Ultrasound in Obstetrics and Gynecology.
The Strong Property (B) for $$L_p$$ Spaces
Authors: Martínez-Abejón Antonio 
Published: November 2021

AbstractGiven a purely non-atomic, finite measure space $$(\Omega ,\Sigma ,\nu )$$

(
Ω
,
Σ
,
ν
)

, it is proved that for every closed, infinite-dimensional subspace V of $$L_p(\nu )$$

L
p

(
ν
)

($$1\le p<\infty $$

1
≤
p
<
∞

) there exists a decomposition $$L_p(\nu )=X_1\oplus X_2$$

L
p

(
ν
)

=

X
1

⊕

X
2

, such that both subspaces $$X_1$$

X
1

and $$X_2$$

X
2

are isomorphic to $$L_p(\nu )$$

L
p

(
ν
)

and both $$V\cap X_1$$

V
∩

X
1

and $$V\cap X_2$$

V
∩

X
2

are infinite-dimensional. Some consequences concerning dense, non-closed range operators on $$L_1$$

L
1

are derived.
Entwicklung einer Riesenbulla unter Spontanatmung durch „patient self-inflicted lung injury“ bei COVID-19-Pneumonie
Authors: Moellhoff Nicholas , Groene Philipp , Ney Ludwig , Hauer Daniela 
Published: November 2021

ZusammenfassungSARS-CoV‑2 und die damit assoziierte COVID-19-Erkrankung stellen Gesundheitssysteme weltweit vor große Herausforderungen. Fast täglich werden neue Erkenntnisse zu Diagnostik, Klinik und Therapie der Erkrankung publiziert. Dieser Fallbericht beschreibt den letalen Krankheitsverlauf eines 81-jährigen Patienten ohne pulmonale Vorerkrankungen, der als Komplikation der COVID-19-Pneumonie unter nichtinvasiver High-Flow-Sauerstofftherapie eine Riesenbulla entwickelte. Pathophysiologisch kommen/kommt eine virusbedingte diffuse Zerstörung des Alveolargewebes und/oder die „patient self-inflicted lung injury“ in Betracht.
Non-tautological Hurwitz cycles
Authors: Lian Carl 
Published: November 2021

AbstractWe show that various loci of stable curves of sufficiently large genus admitting degree d covers of positive genus curves define non-tautological algebraic cycles on $${\overline{{\mathcal {M}}}}_{g,N}$$

M
¯

g
,
N

, assuming the non-vanishing of the d-th Fourier coefficient of a certain modular form. Our results build on those of Graber-Pandharipande and van Zelm for degree 2 covers of elliptic curves; the main new ingredient is a method to intersect the cycles in question with boundary strata, as developed recently by Schmitt-van Zelm and the author.
Effects of static load and residual stress on fused silica direct bonding interface properties
Authors: Birckigt Pascal , Grabowski Kevin , Leibeling Gilbert , Flügel-Paul Thomas , Heusinger Martin , Ouslimani Hana , Risse Stefan 
Published: November 2021

AbstractDefect free direct bonding of rigid and large area glass samples, such as prisms, becomes increasingly important for the manufacturing of modern optical and optomechanical components. Typically, in order to apply a static load during the annealing step, specialized heat-resistant pressure mountings are required. This makes manufacturing effortful and cost-intensive. In this paper, we present plasma activated bonding experiments conducted on fused silica plates where residual stress has been introduced prior to the contacting step and where annealing is performed with and without a static load. We find that in case of a sufficiently smooth surface, bonding strength is insensitive towards residual stress or static load, or more precisely, towards the interface stress. Furthermore, the residual Fresnel reflection losses of the realized bonding interface were optically measured and they amount to only $$10^{-6}$$

10

-
6

. We propose that a consideration of the change in Gibbs free energy, dG, allows qualitatively predicting the resulting bonding strength and its spatial distribution, where dG is determined by surface energy and interface stress. At the end of this article, conceivable applications are discussed.
Chlorantraniliprole application differentially affects adult emergence of Sympetrum dragonflies in rice paddy fields
Authors: Nakanishi Kosuke , Usio Nisikawa , Yokomizo Hiroyuki , Takashima Tadao , Hayashi Takehiko I. 
Published: November 2021

AbstractRice paddy fields are important habitat for many dragonfly species. In Japan, populations of dragonflies inhabiting rice paddies, in particular Sympetrum (Odonata: Libellulidae), have decreased greatly in the last few decades. A major cause of the decline has been suggested to be the use of systemic insecticides (e.g., phenylpyrazole and neonicotinoid) in nursery boxes of rice seedlings. In this study, we examined the effects of chlorantraniliprole (CAP), a novel anthranilic diamide insecticide, on adult emergence of Sympetrum dragonflies in ten rice paddy fields by counting their exuviae remaining on the rice plants as an abundance index. Our results suggest that CAP is a potential factor that reduced the emergence rate of S. infuscatum but not of S. frequens. This difference may be due to differential sensitivity to CAP, different lengths of the nymphal stage, or different effects of bottom-up controls via reduction of prey organisms that are highly sensitive to CAP.
On the existence of balanced metrics on six-manifolds of cohomogeneity one
Authors: Alonso Izar , Salvatore Francesca 
Published: November 2021

AbstractWe consider balanced metrics on complex manifolds with holomorphically trivial canonical bundle, most commonly known as balanced SU(n)-structures. Such structures are of interest for both Hermitian geometry and string theory, since they provide the ideal setting for the Hull–Strominger system. In this paper, we provide a non-existence result for balanced non-Kähler $$\text {SU}(3)$$

SU
(
3
)

-structures which are invariant under a cohomogeneity one action on simply connected six-manifolds.
Portfolio optimization with optimal expected utility risk measures
Authors: Geissel S. , Graf H. , Herbinger J. , Seifried F. T. 
Published: November 2021

AbstractThe purpose of this article is to evaluate optimal expected utility risk measures (OEU) in a risk-constrained portfolio optimization context where the expected portfolio return is maximized. We compare the portfolio optimization with OEU constraint to a portfolio selection model using value at risk as constraint. The former is a coherent risk measure for utility functions with constant relative risk aversion and allows individual specifications to the investor’s risk attitude and time preference. In a case study with three indices, we investigate how these theoretical differences influence the performance of the portfolio selection strategies. A copula approach with univariate ARMA-GARCH models is used in a rolling forecast to simulate monthly future returns and calculate the derived measures for the optimization. The results of this study illustrate that both optimization strategies perform considerably better than an equally weighted portfolio and a buy and hold portfolio. Moreover, our results illustrate that portfolio optimization with OEU constraint experiences individualized effects, e.g., less risk-averse investors lose more portfolio value in the financial crises but outperform their more risk-averse counterparts in bull markets.
Regional expansion of emerging market SMEs: the roles of domestic market environmental uncertainty and international alliance partner diversity
Authors: Zahoor Nadia , Donbesuur Francis , Nwoba Arinze Christian , Khan Huda 
Published: November 2021

AbstractThis study develops and tests a framework of the effect of domestic market environmental uncertainty on international alliance partner diversity (IAPD) and the effect of IAPD on small and medium-sized enterprises’ (SMEs’) regional expansion. Leveraging primary data from a sample of 232 Pakistani SMEs, the findings indicate that domestic market dynamism and technological dynamism drive SMEs to engage in IAPD. The analysis further reveals that IAPD improves SMEs’ regional expansion, and particularly so at higher levels of cross-cultural knowledge absorption. The research and practical implications of these findings are discussed.
Functional Connectivity Lateralisation Shift of Resting State Networks is Linked to Visuospatial Memory and White Matter Microstructure in Relapsing–Remitting Multiple Sclerosis
Authors: Veréb Dániel , Kovács Márton Attila , Kocsis Krisztián , Tóth Eszter , Bozsik Bence , Király András , Kincses Bálint , Faragó Péter , Fricska-Nagy Zsanett , Bencsik Krisztina , Klivényi Péter , Kincses Zsigmond Tamás , Szabó Nikoletta 
Published: November 2021

AbstractLaterality patterns of resting state networks (RSN) change in various neuropsychiatric conditions. Multiple sclerosis (MS) causes neuro-cognitive symptoms involving dysfunctional large-scale brain networks. Yet, whether healthy laterality patterns of RSNs are maintained in MS and whether altered laterality patterns explain disease symptoms has not been explicitly investigated. We analysed functional MRI and diffusion tensor imaging data from 24 relapsing–remitting MS patients and 25 healthy participants. We performed group-level independent component analysis and used dual regression to estimate individual versions of well-established RSNs. Voxelwise laterality indices were calculated for each RSN. Group differences were assessed via a general linear model-based approach. The relationship between functional laterality and white matter microstructural asymmetry was assessed using Tract-Based Spatial Statistics. Spearman’s correlation was calculated between laterality indices and Brief International Cognitive Assessment for Multiple Sclerosis scores. Functional laterality of the dorsal attention network showed a significant leftward shift in the MS group in the posterior intraparietal sulcus (p < 0.033). Default-mode network laterality showed a significant leftward shift in the MS group in the angular gyrus (p < 0.005). Diminished dorsal attention network laterality was associated with increased fractional anisotropy asymmetry in the superior longitudinal fasciculus (p < 0.02). In the default-mode network, leftward laterality of the angular gyrus was associated with higher BVMT-R scores (R = − 0.52, p < 0.023). Our results confirm previous descriptions of RSN dysfunction in relapsing–remitting MS and show that altered functional connectivity lateralisation patterns of RSNs might contibute to cognitive performance and structural remodellation even in patients with mild clinical symptoms.
Determinants of substantial public debt reductions in Central and Eastern European Countries
Authors: Semik Sofia , Zimmermann Lilli 
Published: November 2021

AbstractGovernment debt development is a timeless issue in economics that has gained even more attention in light of the global financial crisis and the Covid 19 pandemic crisis. The following paper uses several specifications of a logistic probability model to examine the key determinants underlying substantial public debt reductions in Central and Eastern European EU Member States for the period 1996–2020. The results suggest that fiscal adjustments are more likely to be successful in reducing public debt if they are based on expenditure cuts rather than revenue increases. In this context, cuts in social benefits and government employee compensation prove to be particularly effective. In addition, favourable economic growth rates increase the probability of a substantial reduction in government debt.
Redo accessory pathway ablation in the pediatric population
Authors: Corcia M. Cecilia Gonzalez , Stuart Graham , Walsh Mark , Radulescu Cristina , Spera Francesco , Tijskens Maxime , Heidbuchel Hein , Sarkozy Andrea 
Published: November 2021

Abstract
Background
Literature reports 5% of recurrence/failure in paediatric accessory pathway ablations. Our aim was to investigate the reasons underlying this finding and share techniques to obtain long-term success.

Methods
Thirty-nine paediatric patients referred for a repeat procedure were analysed: characteristics of the pathways and the initial and redo procedures were identified.

Results
Mean age was 11.9 ± 3.3 years (59% males). Three patients (8%) had multiple accessory pathways. The most frequent location was left lateral (26%). Left sided pathway recurrence was caused mainly by poor contact (60%) and inadequate mapping (40%). For right lateral accessory pathways, poor contact accounted for 70% of failures. For antero-septal and para-Hisian locations, the use of cryoablation and choice of low radiofrequency energy delivery accounted for > 75% of failures. Long-term success strategies included choice of contact force catheters and radiofrequency applications at the ventricular insertion of the pathway and in the aortic coronary cusps. In postero-septal substrates, the main reason accounting for failure was deep or epicardial location of the pathway (37%), solved by using an irrigated tip catheter or applying lesions within the coronary sinus, or applications from both right and left postero-septal areas.

Conclusion
Acute failure and post-procedure recurrence in paediatric accessory pathway ablations have multiple reasons related to the characteristics of the pathway and the technology available. Accurate understanding of the anatomy, careful mapping and pacing manoeuvers, and incorporation of new technologies contribute to achieve a definitive success in > 98% of procedures.
Life-cycle impact assessment methods for physical energy scarcity: considerations and suggestions
Authors: Arvidsson Rickard , Svanström Magdalena , Harvey Simon , Sandén Björn A. 
Published: November 2021

Abstract
Purpose
Most approaches for energy use assessment in life cycle assessment do not consider the scarcity of energy resources. A few approaches consider the scarcity of fossil energy resources only. No approach considers the scarcity of both renewable and non-renewable energy resources. In this paper, considerations for including physical energy scarcity of both renewable and non-renewable energy resources in life cycle impact assessment (LCIA) are discussed.

Methods
We begin by discussing a number of considerations for LCIA methods for energy scarcity, such as which impacts of scarcity to consider, which energy resource types to include, which spatial resolutions to choose, and how to match with inventory data. We then suggest three LCIA methods for physical energy scarcity. As proof of concept, the use of the third LCIA method is demonstrated in a well-to-wheel assessment of eight vehicle propulsion fuels.

Results and discussion
We suggest that global potential physical scarcity can be operationalized using characterization factors based on the reciprocal physical availability for a set of nine commonly inventoried energy resource types. The three suggested LCIA methods for physical energy scarcity consider the following respective energy resource types: (i) only stock-type energy resources (natural gas, coal, crude oil and uranium), (ii) only flow-type energy resources (solar, wind, hydro, geothermal and the flow generated from biomass funds), and (iii) both stock- and flow-type resources by introducing a time horizon over which the stock-type resources are distributed. Characterization factors for these three methods are provided.

Conclusions
LCIA methods for physical energy scarcity that provide meaningful information and complement other methods are feasible and practically applicable. The characterization factors of the three suggested LCIA methods depend heavily on the aggregation level of energy resource types. Future studies may investigate how physical energy scarcity changes over time and geographical locations.