bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association Between Notching of the Right Ventricular Outflow Tract Flow Velocity Doppler Envelope and Impaired Right Ventricular Function After Acute High-Altitude Exposure
Authors: Yuan Fangzhengyuan , Liu Chuan , Yu Shiyong , Bian Shizhu , Yang Jie , Ding Xiaohan , Zhang Jihang , Tan Hu , Ke Jingbin , Yang Yuanqi , He Chunyan , Zhang Chen , Rao Rongsheng , Liu Zhaojun , Yang Jun , Huang Lan 
Published: April 2021

IntroductionPulmonary artery pressure (PAP) is increased and right ventricular (RV) function is well preserved in healthy subjects upon exposure to high altitude (HA). An increase in PAP may trigger notching of the right ventricular outflow tract Doppler flow velocity envelope (RVOT notch), which is associated with impaired RV function in patients with pulmonary hypertension. However, whether HA exposure can induce RVOT notch formation and the subsequent impact on cardiac function in healthy subjects remains unclear.MethodsA total of 99 subjects (69 males and 30 females) with a median age of 25 years were enrolled in this study; they traveled from 500 to 4100 m by bus over a 2-day period. All subjects underwent a comprehensive physiological and echocardiographic examination 1 day before ascension at low altitude and 15 ± 3 h after arrival at HA. The RVOT notch was determined by the presence of a notched shape in the RVOT Doppler flow velocity envelope. The systolic PAP (SPAP) was calculated as Bernoulli equation SPAP = 4 × (maximum tricuspid regurgitation velocity)2+5 and mean PAP (mPAP) = 0.61 × SPAP+2. Cardiac output was calculated as stroke volume × heart rate. Pulmonary capillary wedge pressure (PCWP) was calculated as 1.9+1.24 × mitral E/e’. Pulmonary vascular resistance (PVR) was calculated as (mPAP-PCWP)/CO.ResultsAfter HA exposure, 20 (20.2%) subjects had an RVOT notch [notch (+)], and 79 (79.8%) subjects did not have an RVOT notch [notch (−)]. In the multivariate logistic regression analysis, the SPAP, right ventricular global longitude strain (RV GLS), and tricuspid E/A were independently associated with the RVOT notch. The SPAP, mPAP, PVR, standard deviations of the times to peak systolic strain in the four mid-basal RV segments (RVSD4), peak velocity of the isovolumic contraction period (ICV), and the peak systolic velocity (s’) at the mitral/tricuspid annulus were increased in all subjects. Conversely, the pulse oxygen saturation (SpO2), RV GLS, and tricuspid annulus plane systolic excursion (TAPSE)/SPAP were decreased. However, the increases of SPAP, mPAP, PVR, and RVSD4 and the decreases of SpO2, RV GLS, and TAPSE/SPAP were more pronounced in the notch (+) group than in the notch (−) group. Additionally, increased tricuspid ICV and mitral/tricuspid s’ were found only in the notch (−) group.ConclusionHA exposure-induced RVOT notch formation is associated with impaired RV function, including no increase in the tricuspid ICV or s’, reduction of RV deformation, deterioration in RV-pulmonary artery coupling, and RV intraventricular synchrony.
Identification and Functional Analysis of Long Non-coding RNAs in Human Pulmonary Microvascular Endothelial Cells Subjected to Cyclic Stretch
Authors: Wang Dong , Dai Chenyang , Zhang Xiaoning , Gu Changping , Liu Mengjie , Liu Huan , Yang Fan , Wu Haifeng , Wang Yuelan 
Published: April 2021

Background: Despite decades of intense research, the pathophysiology and pathogenesis of acute respiratory distress syndrome (ARDS) are not adequately elucidated, which hamper the improvement of effective and convincing therapies for ARDS patients. Mechanical ventilation remains to be one of the primary supportive approaches for managing ARDS cases. Nevertheless, mechanical ventilation leads to the induction of further aggravating lung injury which is known as leading to ventilator-induced lung injury (VILI). It has been reported that lncRNAs play important roles in various cellular process through transcriptional, posttranscriptional, translational, and epigenetic regulations. However, to our knowledge, there is no investigation of the expression profile and functions of transcriptome-level endothelium-related lncRNAs in VILI yet.Methods: To screen the differential expression of lncRNAs and mRNAs in Human pulmonary microvascular endothelial cells (HPMECs) subjected to cyclic stretch, we constructed a cellular model of VILI, followed by transcriptome profiling using Affymetrix Human Transcriptome Array 2.0. Bioinformatics analyses, including functional and pathway enrichment analysis, protein–protein interaction network, lncRNA-mRNA coexpression network, and cis-analyses, were performed to reveal the potential functions and underlying mechanisms of differentially expressed lncRNAs.Results: In total, 199 differentially expressed lncRNAs (DELs) and 97 differential expressed mRNAs were screened in HPMECs subjected to 20% cyclic stretch for 2 h. The lncRNA-mRNA coexpression network suggested that DELs mainly enriched in response to hypoxia, response to oxidative stress, inflammatory response, cellular response to hypoxia, and NF-kappa B signaling pathway. LncRNA n335470, n406639, n333984, and n337322 might regulate inflammation and fibrosis induced by cyclic stretch through cis- or trans-acting mechanisms.Conclusion: This study provides the first transcriptomic landscape of differentially expressed lncRNAs in HPMECs subjected to cyclic stretch, which provides novel insights into the molecular mechanisms and potential directions for future basic and clinical research of VILI.
The Prevalence of Depression and Its Association With Quality of Life Among Pregnant and Postnatal Women in China: A Multicenter Study
Authors: Bo Hai-Xin , Yang Yuan , Zhang Dong-Ying , Zhang Meng , Wang Pei-Hong , Liu Xiao-Hua , Ge Li-Na , Lin Wen-Xuan , Xu Yang , Zhang Ya-Lan , Li Feng-Juan , Xu Xu-Juan , Wu Hong-He , Jackson Todd , Ungvari Gabor S. , Cheung Teris , Xiang Yu-Tao 
Published: April 2021

Background: This study examined the prevalence of depressive symptoms (depression hereafter) and its association with quality of life (QOL) among pregnant and postnatal women in China.Methods: In this multi-center, cross-sectional study, 1,060 pregnant and postnatal women from eight hospitals were assessed. Depression and QOL were measured using the Edinburgh Postnatal Depression Scale and the World Health Organization Quality of Life Questionnaire - brief version, respectively.Results: The prevalence of depression was 7.45% (95% CI: 5.87–9.04%) in the sample. Women with depression had lower QOL in physical, psychological, social and environmental domains compared to those without. Women with physical comorbidities were more likely to suffer from depression (OR = 2.391, 95% CI = 1.384–4.130, P = 0.002).Conclusion: Due to its negative association with QOL, increased attention should be paid to depression in pregnant and postnatal women. Regular screening assessment and preventive measures should be adopted to reduce risk of depression in this population.
Child Mental Health in HIV-Impacted Low-Resource Settings in Developing Countries-Global Research Fellowship: A Research Training Program Protocol
Authors: Ssewamala Fred M. , Sensoy Bahar Ozge , Nakasujja Noeline , Abente Betsy , Nabunya Proscovia , Peer Laura , Zmachinski Lily , Fragale Suzanne , McKay Mary M. 
Published: April 2021

Background:Uganda has one of the highest HIV/AIDS rates and poor mental health services. Children and adolescents in communities with persistent poverty, disease (including HIV/AIDS), and violence, are more likely to suffer from chronic mental health problems. Combined, these characteristics negatively impact communities' response to HIV and mental health beginning with children, adolescents, and young adults. Yet, there is limited research capacity in child and adolescent mental health (CAMH), especially in the HIV/AIDS context in Uganda. Hence, this NIH-funded research training program aims to: (1) train three cohorts of early-career investigators at universities or research institutions in Uganda; (2) connect fellows with committed mentors; and (3) define key factors for successful mentorship and training of new investigators.Methods:CHILD-GRF is a multi-component program that engages selected young investigators in year-round activities for 3 years. Paired with mentors from Washington University in St. Louis and academic institutions in Uganda, fellows participate in a 6-week intensive summer training each year. Year 1 focuses on didactic learning and mentorship. In Year 2, fellows design and conduct their pilot study. Year 3 is devoted to presenting pilot study findings, manuscript preparation/ submission and extramural grant writing.Discussion:CHILD-GRF seeks to provide a solid foundation for the development and implementation of evidence-based HIV prevention and mental health interventions for youth and families impacted by HIV/AIDS. By producing a sustainable network of well-trained individuals in key research institutions, this program contributes to improving CAMH and HIV prevention efforts, both of which have public health implications.
Identification of Potential Biomarkers From Hepatocellular Carcinoma With MT1 Deletion
Authors: Zhang Ruohao , Huang Miao , Wang Hong , Wu Shengming , Yao Jiali , Ge Yingying , Lu Yufei , Hu Qiping 
Published: April 2021

Background: Hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide. Metallothioneins (MTs) are metal-binding proteins involved in multiple biological processes such as metal homeostasis and detoxification, as well as in oncogenesis. Copy number variation (CNV) plays a vital role in pathogenesis and carcinogenesis. Nevertheless, there is no study on the role of MT1 CNV in HCC.Methods: Array-based Comparative Genomic Hybridization (aCGH) analysis was performed to obtain the CNV data of 79 Guangxi HCC patients. The prognostic effect of MT1-deletion was analyzed by univariate and multivariate Cox regression analysis. The differentially expressed genes (DEGs) were screened based on The Gene Expression Omnibus database (GEO) and the Liver Hepatocellular Carcinoma of The Cancer Genome Atlas (TCGA-LIHC). Then function and pathway enrichment analysis, protein-protein interaction (PPI) and hub gene selection were applied on the DEGs. Lastly, the hub genes were validated by immunohistochemistry, tissue expression and prognostic analysis.Results: The MT1-deletion was demonstrated to affect the prognosis of HCC and can act as an independent prognostic factor. 147 common DEGs were screened. The most significant cluster of DEGs identified by Molecular Complex Detection (MCODE) indicated that the expression of four MT1s were down-regulated. MT1X and other five hub genes (TTK, BUB1, CYP3A4, NR1I2, CYP8B1) were associated with the prognosis of HCC. TTK, could affect the prognosis of HCC with MT1-deletion and non-deletion. NR1I2, CYP8B1, and BUB1 were associated with the prognosis of HCC with MT1-deletion.Conclusions: In the current study, we demonstrated that MT1-deletion can be an independent prognostic factor in HCC. We identified TTK, BUB1, NR1I2, CYP8B1 by processing microarray data, for the first time revealed the underlying function of MT1 deletion in HCC, MT1-deletion may influence the gene expression in HCC, which may be the potential biomarkers for HCC with MT1 deletion.
Development of a Novel Prognostic Signature Based on Antigen Processing and Presentation in Patients with Breast Cancer
Authors: Qi Aoshuang , Ju Mingyi , Liu Yinfeng , Bi Jia , Wei Qian , He Miao , Wei Minjie , Zhao Lin 
Published: April 2021

Background: Complex antigen processing and presentation processes are involved in the development and progression of breast cancer (BC). A single biomarker is unlikely to adequately reflect the complex interplay between immune cells and cancer; however, there have been few attempts to find a robust antigen processing and presentation-related signature to predict the survival outcome of BC patients with respect to tumor immunology. Therefore, we aimed to develop an accurate gene signature based on immune-related genes for prognosis prediction of BC.Methods: Information on BC patients was obtained from The Cancer Genome Atlas. Gene set enrichment analysis was used to confirm the gene set related to antigen processing and presentation that contributed to BC. Cox proportional regression, multivariate Cox regression, and stratified analysis were used to identify the prognostic power of the gene signature. Differentially expressed mRNAs between high- and low-risk groups were determined by KEGG analysis.Results: A three-gene signature comprising HSPA5 (heat shock protein family A member 5), PSME2 (proteasome activator subunit 2), and HLA-F (major histocompatibility complex, class I, F) was significantly associated with OS. HSPA5 and PSME2 were protective (hazard ratio (HR) &lt; 1), and HLA-F was risky (HR &gt; 1). Risk score, estrogen receptor (ER), progesterone receptor (PR) and PD-L1 were independent prognostic indicators. KIT and ACACB may have important roles in the mechanism by which the gene signature regulates prognosis of BC.Conclusion: The proposed three-gene signature is a promising biomarker for estimating survival outcomes in BC patients.
Approximate Analytical Analysis of Unsteady MHD Mixed Flow of Non-Newtonian Hybrid Nanofluid over a Stretching Surface
Authors: Rehman Ali , Salleh Zabidin 
Published: April 2021

This paper analyses the two-dimensional unsteady and incompressible flow of a non-Newtonian hybrid nanofluid over a stretching surface. The nanofluid formulated in the present study is TiO2 + Ag + blood, and TiO2 + blood, where in this combination TiO2 + blood is the base fluid and TiO2 + Ag + blood represents the hybrid nanofluid. The aim of the present research work is to improve the heat transfer ratio because the heat transfer ratio of the hybrid nanofluid is higher than that of the base fluid. The novelty of the recent work is the approximate analytical analysis of the magnetohydrodynamics mixed non-Newtonian hybrid nanofluid over a stretching surface. This type of combination, where TiO2+blood is the base fluid and TiO2 + Ag + blood is the hybrid nanofluid, is studied for the first time in the literature. The fundamental partial differential equations are transformed to a set of nonlinear ordinary differential equations with the guide of some appropriate similarity transformations. The analytical approximate method, namely the optimal homotopy analysis method (OHAM), is used for the approximate analytical solution. The convergence of the OHAM for particular problems is also discussed. The impact of the magnetic parameter, dynamic viscosity parameter, stretching surface parameter and Prandtl number is interpreted through graphs. The skin friction coefficient and Nusselt number are explained in table form. The present work is found to be in very good agreement with those published earlier.
Communist International, the Soviet Union, and their impact on the Latin America Workers' Movement
Authors: Botz Dan La 
Published: April 2021

The Soviet Union and the Communist International had an adverse influence on the Latin American workers’ movement, continually diverting it fighting for a emocratic socialist society. They subordinated the workers’ movements to the interests of the Soviet Union’s ruling class, the Communist bureaucracy. At one oment, they led the workers’ movement in disastrous uprisings, while in a subsequent era they encouraged it to build alliances with capitalist and imperialist power.
Petróleo y nación
Authors: Riquelme Milton Waldemar 
Published: April 2021

En esta reflexión se elabora una breve presentación de las obras “Nacionalismo y petróleo” de Gabriel Cohn y “Petróleo y política” de Arturo Frondizi. Exponemos las tensiones previas a la creación de las empresas Petrobras en Brasil e YPF en Argentina frente a los intereses de empresas extranjeras. Finalmente, nos proponemos un contrapunto sobre las políticas en el área petrolera entre ambos países desde el descubrimiento hacia mediados del siglo pasado.
nova Guerra Fria de Hugo Chávez
Authors: Baburkin Sergei A. 
Published: April 2021

Após a Guerra Fria, potências intermediárias lutam para obter melhores posições em suas relações com os Estados Unidos e o sistema global. Analisando as relações triangulares entre Venezuela – Rússia – Estados Unidos os autores detectam a persistência de elementos ideológicos e de segurança da Guerra Fria bem como a probabilidade de um retorno a práticas políticas dadas como superadas.
Subimperialismo e particularidade brasileira
Authors: Macário Epitácio , Júnior Natan dos Santos 
Published: April 2021

Este artigo discute o conceito de subimperialismo formulado por Ruy Mauro Marini sob a ótica da Teoria Marxista da Dependência. O ensaísta demonstraque na particularidade brasileira a acumulação de capital põe e repõe, continuamente, a superexploração do trabalho e a segmentação do mercado interno, o que condiciona um avanço de capitais acumulados no Brasil sobre outras nações periféricas, tornando o País uma potência subimperialista, ainda que dependente.
Pengelolaan Wisata Halal Di Situs Guha Jepang Gampong Blang Panyang Kota Lhokseumawe Aceh
Authors: Rahman Bobby , Rasyidin Rasyidin , Muzaffarsyah Teuku , Zulhilmi Zulhilmi 
Published: April 2021

The purpose of this service is to realize community service planning conducted with Forum Group Discussion (FGD) in Gampong Balang Panyang with Gampong Leadership, Tuha Peut and other youth figures and Stake holders. There are several problems behind this devotion, namely the management of tourism things have not been managed properly in accordance with Islamic law, the method of Devotion Activities is based on the principle of participatory towards all parties involved. Planning together, conducting activities, monitoring and evaluating together the extent of the progress of the activities. As a result, This Japanese Guha tourist site can also be a means of education as well as an additional literacy about the history of the past. Of course, this becomes a picture that the management must be maximized and the development to all citizens in developing halal tourism potential in the historical site. in conclusion, the management of Guha Japan Tourism Site became the authority of the Lhokseumawe City Government through the Tourism Office and the Education and Culture Office. This makes the management of Japan Guha tourism has not been maximized.
«COMPLЕXITY» AND «PERPLEXITY» – CATEGORIES OF DEVELOPMENT OF GOVERNANCE SYSTEMS
Authors: Alekseev M. A. , Freydina E. V. , Petukhova S. V. , Tropin A. A. 
Published: April 2021

Addressing the issue of «complexity» and «perplexity» categories is caused by the evolution of system types ranging from well-organized to self-organizing, expanding the horizons of scientific rationality. Development of governance systems is revealed through the dichotomy of properties and restrictions within the «organizational set-up» and «external influence» notions. It was shown that the governance system falls into the category of complexity because the system is operating on the edge of «order and chaos». External environment is presented as chaos analogue showing uncertainty and changes of various fluctuation category, up to turbulence. The incorporation of social and economic system into external environment was considered from the perspective of formation of «system convergence» of two open systems, contributing to growth of the degree of complexity of governance system. It was emphasized that business development forces perplexity governance systems to switch to robust control; the mechanism of robust control is organized under the influence of the laws of evolution and survivability of biosystems. The following methods were marked out and justified: selection of parameters for system convergence of governance system with external environment entities, determination of limits of information granules of adaptive and robust homeostasis, scenario planning, construction of convergent strategy and temporal attractor of system equilibrium state, known as «floating equilibrium». These methods are to be mastered by the governance system within robust control.
ASSESSMENT OF THE CONTRIBUTION OF EDUCATIONAL INSTITUTION TO STAFFING OF REGIONAL ECONOMY (BASED ON MATERIALS OF ALTAI STATE UNIVERSITY)
Authors: Shvakov E. E. , An E. A. 
Published: April 2021

One of the most difficult tasks of regional vocational education systems is to provide training in accordance with the needs of the regional economy. This requires not only an analysis of the regional economy’s need for personnel by type of economic activity and level of education, but also the ability of educational institutions in the region to meet this need. This article offers a methodological approach to assessing the capabilities of a professional educational institution to provide personnel to certain sectors of the regional economy. The materials of the Altai state University show the University’s contribution to covering the region’s personnel needs and show the potential for increasing the employment of graduates in certain sectors of the economy of the Altai territory. Measures aimed at increasing the University’s contribution to covering the region’s staffing needs are proposed.
State of The Art on The Main Randomized Clinical Studies, Meta-Analysis, and International Consensus on The Influence of Serum Levels and Supplementation of Vitamin D on Athletes Performance
Authors: Woitas Leandro Reis , Ribas José Wilson , Zotarelli Filho Idiberto José 
Published: April 2021

Introduction: Vitamin D (VD) deficiency (serum 25-hydroxyvitamin D (25 (OH) D) <50 nmol/L or 20 ng/mL) is more common than is thought in the majority of the world population. In this context, athletes have the same predisposition to low levels of vitamin D, with the majority of their concentrations below 20 ng/mL in a wide variety of sports, especially in the winter months. RV is also essential in extra-skeletal functions, including skeletal muscle growth, immune and cardiopulmonary functions, and inflammatory modulation, which influence athletic performance. Vitamin D can also interact with extra-skeletal tissues to modulate injury recovery and also influence the risk of infection. Objective: Performed a wide analysis of the world literature to compose the State of the Art on the main effects of vitamin D supplementation on the performance of athletes through randomized clinical studies, meta-analysis, and the latest international conferences and consensus. Methods: The present study followed a broad literature review of randomized clinical studies, meta-analysis, and the latest international consensus. The Cochrane instrument was adopted to assess the quality of the studies. Main findings and conclusion: One of the main aspects that must be taken into account is important evidence that suggests that free (bioavailable) 25(OH)D may be a better marker of vitamin D status. Many researchers do not take into account that athletes may need a greater supply of vitamin D to meet the requirements of muscle metabolism due to the potential routes of vitamin D use. A significant debate seems to be needed to determine and standardize the classification of vitamin D deficiency. There are still information gaps on the correlation between vitamin D supplementation and athletes' exercise performance. However, because vitamin D induces myogenesis and muscle protein synthesis, causing an increase in the percentage of rapidly contracting muscle cells, and because vitamin D receptors (VDR) play a significant role in muscle regeneration after injury, supplementation in athletes is recommended.