bluuebunny/crossref_metadata_2025_split huggingface dataset:
Live birth rate with double ovarian stimulation is superior to follicular phase ovarian stimulation per started cycle in poor ovarian responders
Authors: Oral Serkan , Karacan Meriç , Akpak Yaşam K. , Şişmanoğlu Alper , Sancaklı Usta Ceyda 
Published: June 2021

AbstractAimTo compare the outcome of double ovarian stimulation (DOS) with follicular phase ovarian stimulation (FPS) per started cycle in poor ovarian responders (PORs).MethodsA total of 204 PORs who underwent ovulation induction for in vitro fertilization, cryopreservation of all embryos available, and frozen embryo transfer cycle were retrospectively analyzed. Of those, 146 received single FPS, and 58 received DOS. All viable embryos were cryopreserved and subsequently transferred within 1–6 months.ResultsThe number of oocytes collected and the number of mature oocytes per started cycle were higher in the DOS group compared to the FPS group (6.0 ± 1.9 vs. 2.8 ± 1.3 and 4.3 ± 1.3 vs. 2.2 ± 1.2, respectively, p = 0.001). Clinical pregnancy rate and live birth rate per started cycle were also significantly higher in the DOS group than the FPS group (41.4% vs. 16.4% and 36.2% vs. 15.1%, respectively, p < 0.001). The cancellation rate of embryo transfer due to no viable embryo was significantly lower in the DOS group (10.3%) than the FPS group (40.4%) (p = 0.001). In the DOS group, numbers of oocytes (3.2 ± 1.2 vs. 2.7 ± 1.1, p = 0.006), MII oocytes (2.6 ± 1.0 vs. 2.1 ± 0.8, p = 0.001), and cryopreserved blastocysts (1.5 ± 0.8 vs. 1.1 ± 0.7, p = 0.002) were significantly higher in the luteal ovarian stimulation compared to follicular ovarian stimulation.ConclusionsLive birth per started cycle with DOS is superior to FPS in PORs. Luteal phase stimulation contributes to improving pregnancy rates in these patients.
The level of depression, anxiety, and sleep quality in pregnancy during coronavirus disease 2019 pandemic
Authors: Çolak Sabri , Gürlek Beril , Önal Özgür , Yılmaz Bülent , Hocaoglu Cicek 
Published: June 2021

AbstractAimWe aimed to evaluate the mental health and sleep quality of pregnant women in different trimesters during coronavirus disease 2019 (COVID‐19) pandemic and investigate the effect of quarantine and new lifestyle changes that come into our lives with pandemic with on this subject.MethodsIt was conducted on pregnant women (n = 149) who attended routine pregnancy prenatal visit during their pregnancy weeks. The data were collected using sociodemographic and clinical data form, Pittsburgh Sleep Quality Index (PSQI) to evaluate sleep quality, Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) to evaluate maternal depression and anxiety.ResultsA significant correlation was observed between the week of gestation and depression, anxiety, and defective sleep scores (p < 0.001). A moderate positive correlation was found between the week of gestation and depression (r: 0.628). A high level of positive correlation was found between the week of gestation and defective sleep quality and anxiety scores (r: 0.858, r: 0.754). A statistically significant increase in depression, anxiety, and defective sleep quality was found in the group staying in home quarantine (p = 0.002).ConclusionThis study showed that the COVID‐19 pandemic can cause depression, anxiety, and serious sleep disorders in pregnant women. The depression and anxiety scores of pregnant women in home quarantine were also found to be higher than the group not in quarantine. As the week of gestation progresses, mental health symptoms worsen and sleep quality deteriorates.
Development of a 3‐Day Intervention Program for Family Members of Hikikomori Sufferers1
Authors: Kubo Hiroaki , Urata Hiromi , Sakai Motohiro , Nonaka Shunsuke , Kishimoto Junji , Saito Kazuhiko , Tateno Masaru , Kobara Keiji , Fujisawa Daisuke , Hashimoto Naoki , Suzuki Yuriko , Honda Yoko , Otsuka Kotaro , Kanba Shigenobu , Kuroki Toshihide , Kato Takahiro A. 
Published: June 2021

AbstractHikikomori (a severe form of social withdrawal) is a serious mental health issue. A family approach is the initial step to support hikikomori; thus effective family intervention programs are warranted. We recently developed a 5‐day family intervention program (120 min weekly) based on Mental Health First Aid (MHFA) and Community Reinforcement and Family Training (CRAFT). In the present study, we modified the 5‐day program to a 3‐day program (180 min fortnightly), and examined the effectiveness of the 3‐day program using a single‐arm procedure. Data of 23 parents (four fathers and 19 mothers; age = 62.0 ± 9.1 years) were analyzed. Mental health conditions among participants themselves improved at the 4‐month follow‐up, but the confidence in hikikomori support declined and stigma toward mental health problems did not change. However, short‐term improvements in perceived skills in approaching hikikomori sufferers were detected. Hikikomori sufferers’ actual behavioral changes, such as social participation or utilization of support, were also observed (six out of 20 hikikomori sufferers). Preliminary effectiveness was confirmed for the 3‐day program. Further revision of the program and a validation study with controls are required.
Association of markers of endothelial activation and dysfunction with occurrence and outcome of pulmonary hemorrhage in dogs with leptospirosis
Authors: Sonderegger Franziska , Nentwig Alice , Schweighauser Ariane , Francey Thierry , Marti Eliane , Mirkovitch Jelena , Schuller Simone 
Published: June 2021

AbstractBackgroundEndothelial dysfunction might contribute to the development of leptospiral pulmonary hemorrhage syndrome (LPHS).HypothesisSerum concentrations of markers of endothelial activation and dysfunction are higher in dogs with leptospirosis and correlate with the occurrence of LPHS and a higher case fatality rate.AnimalsClinically healthy dogs (n = 31; 10/31 dogs confirmed healthy based on no detected abnormalities on blood work), dogs with leptospirosis with LPHS (n = 17) and without LPHS (n = 15), dogs with acute kidney injury not due to leptospirosis (AKI‐nL, n = 34).MethodsObservational study. Serum concentrations of soluble intercellular adhesion molecule 1 (sICAM‐1), vascular endothelial growth factor (VEGF), and angiopoietin‐2 (Ang‐2) at admission were compared between groups. Correlations with outcome and the accuracy to predict LPHS were examined.ResultsSoluble intercellular adhesion molecule (sICAM‐1), VEGF, and Ang‐2 concentrations were higher in dogs with AKI‐nL (sICAM‐1 34.7 ng/mL, interquartile range [IQR] = 24.4‐75.5; VEGF 43.1 pg/mL, IQR = 12.3‐79.2; Ang‐2 8.5 ng/mL, IQR = 6.2‐12.3), leptospirosis without LPHS (sICAM‐1 45.1 ng/mL, IQR = 30.6‐59.0; VEGF 32.4 pg/mL, IQR = 12.5‐62.6; Ang‐2 9.6 ng/mL, IQR = 6.9‐19.3), and LPHS (sICAM‐1 69.7 ng/mL, IQR = 42.1‐89.1; VEGF 51.8 pg/mL, IQR = 26.3‐96.7; Ang‐2 8.0 ng/mL, IQR = 5.6‐12.2) compared to controls (P < .001). In dogs with leptospirosis, VEGF and sICAM‐1 were higher in nonsurvivors (sICAM‐1 89.4 ng/mL, IQR = 76.5‐101.0; VEGF 117.0 pg/mL, IQR = 90.3‐232.4) than survivors (P = .004) and sICAM‐1 predicted the development of LPHS.ConclusionsSoluble intercellular adhesion molecule 1, VEGF, and Ang‐2 do not discriminate leptospirosis from AKI‐nL. In dogs with leptospirosis, sICAM‐1 and VEGF predict outcome and sICAM‐1 might identify dogs at risk for LPHS.
Overall Cooling Effectiveness of Effusion Cooled Can Combustor Liner Under Reacting and Non-Reacting Conditions
Authors: Ahmed Shoaib , Ramakrishnan Kishore Ranganath , Ekkad Srinath V. 
Published: June 2021

Abstract
Emphasis on lean premixed combustion in modern low NOX combustion chambers limits the air available for cooling the combustion liner. Hence, the development of optimized liner cooling designs is imperative for effective usage of available coolant. An effective way to cool a gas turbine combustor liner is through effusion cooling. Effusion cooling (also known as full-coverage film cooling) involves uniformly spaced holes distributed throughout the liner’s curved surface area. This study presents findings from an experimental study on the characterization of the overall cooling effectiveness of an effusion-cooled liner wall, which was representative of a can combustor under heated flow (non-reacting) and lean-combustion (reacting) conditions. The model can combustor was equipped with an industrial swirler, which subjected the liner walls to engine representative flow and combustion conditions. In this study, two different effusion cooling liners with an inline and staggered arrangement of effusion holes have been studied. Non-dimensionalized streamwise hole-to-hole spacing (z/d) and spanwise hole-to-hole spacing (r/d) of 10 were used for both the effusion liners. These configurations were tested for five different blowing ratios ranging from 0.7 to 4.0 under both reacting and non-reacting conditions. The experiments were carried out at a constant main flow Reynolds number (based on combustor diameter) of 12,500. The non-reacting experiments were carried out by heating the mainstream air, and the reacting experiments were carried out under flame conditions at a total equivalence ratio of 0.65. Infrared thermography (IRT) was used to measure the liner outer surface temperature, and detailed overall effectiveness values were determined under steady-state conditions. It was observed that overall cooling effectiveness trends were different under reacting and non-reacting conditions. The cooling effectiveness for the non-reacting experiments exhibited a decreasing trend, and no consistent location of minimum cooling effectiveness was observed for the range of blowing ratios investigated in this study. For the reacting cases, the cooling effectiveness first follows a decreasing trend, reaches a distinct minimum, and then increases till the end of the combustor. Under non-reacting conditions, the staggered configuration was 9–25% more effective than inline configuration, and under reacting conditions, the staggered configuration was 4–8% more effective than inline configuration. From this study, it is clear that the coolant flame interaction for the reacting experiments impacted the liner cooling effectiveness and led to different overall cooling effectiveness distribution on the liner when compared with the non-reacting experiments.
Modified Hottel-Whillier-Bliss Equation for an Active Solar Distillation System for Higher Yield and Thermal Efficiency
Authors: Tiwari G.N. , Meraj Md. , Khan M.E. , Azhar Md. 
Published: June 2021

Abstract
Based on energy-balance equations for a photo-voltaic thermal (PVT) active solar distillation system, a modified Hottel-Whillier-Bliss (HWB) analytical characteristic equation as a function of design and climatic parameters has been derived in the present article. It has been found that there is a significant difference between characteristic equations for PVT-based active solar distillation and the conventional flat plate collector (FPC). It is due to (i) opposite nature of loss factor from inside surface to ambient through glass cover and (ii) temperature dependence of the evaporative heat transfer coefficient between water surface and condensing cover in the solar distillation system. Numerical computations have been obtained for the characteristic curve of the proposed active solar distillation system and flat plate collector under the condition of a typical day in New Delhi, India. Further, the effect of performance parameters such as packing factor, electrical efficiency of individual PVT collectors, and water mass have also been studied for the proposed active PVT solar distillation system. Moreover, daily yield of portable water has been found to be 7.34 kg/m2 at n = 5 and βc = 0.25 which is 100.5% higher than the daily yield of 3.66 kg/m2 obtained at n = 1, βc. = 0.89.
Systematic survey of K, Th, and U signatures in airborne radiometric data from Australian meteorite impact structures: Possible causes of circular features and implications
Authors: Niang* Cheikh Ahmadou Bamba , Baratoux* David , Diallo* Dina Pathé , Rochette* Pierre , Jessell* Mark W. , Reimold* Wolf U. , Bouley* Sylvain , Vanderhaeghe* Olivier , Faye* Gayane , Lambert* Philippe 
Published: June 2021

ABSTRACT
Airborne radiometric (gamma-ray) data provide estimates of the concentrations of potassium (K), thorium (Th), and uranium (U) in soil, regolith, and bedrock. Radiometric data constitute an important source of geochemical information, commonly used in mineral exploration and for geological mapping of Earth and other planets. Airborne radiometric data have rarely been applied to the exploration and analyses of impact structures, in contrast with other conventional geophysical tools (e.g., gravimetry, magnetism, and seismic reflection/refraction). This work represents the first systematic survey of the K, Th, and U radiometric signatures of Australian impact structures, based on the continent-wide airborne radiometric coverage of Australia. We first formulated several hypotheses regarding the possible causes of formation of circular radiometric patterns associated with impact structures. Then, the radiometric signatures of 17 exposed impact structures in Australia were documented. Our observations confirmed the supposition that impact structures are commonly associated with circular radiometric patterns. We then selected the five structures with the most prominent circular radiometric patterns (Gosses Bluff, Lawn Hill, Acraman, Spider, and Shoemaker), and we discuss the possible origin of these anomalies. Based on these five case studies, we argue that such patterns result from either crustal deformation induced by the impact event and/or from postimpact superficial processes controlled by the crater topography. This work also suggests that airborne radiometric data may be useful, in combination with other geophysical tools, in the search for new possible impact structures.
Shock-twinned zircon in ejecta from the 45-m-diameter Kamil crater in southern Egypt
Authors: Cavosie Aaron J. , Folco Luigi 
Published: June 2021

ABSTRACT
With an age of less than ~5000 yr and a diameter of 45 m, Kamil crater in Egypt is one of the youngest and smallest terrestrial impact craters known to date. Abundant evidence of shock-deformed sandstone has been reported from Kamil crater, including shatter cones, vesicular impact glass, high-pressure polymorphs of silica and carbon, planar deformation features (PDFs) and planar fractures (PFs) in quartz, dissociated zircon, melt veins, and intergranular melt, giving rise to a range of estimated shock pressures from ~20 to ~60 GPa. Here, we investigated shocked zircon from Kamil crater through characterization of microstructures in a centimeter-sized clast of shocked nonporous sandstone ejecta, previously described as containing quartz grains with PDFs and PFs, coesite, stishovite, diamond, and lechatelierite. Orientation analysis by electron backscatter diffraction (EBSD) showed that the quartz arenite consists of damaged detrital quartz grains surrounded by a matrix of either comminuted quartz or intergranular melt. Individual quartz grains are pervasively fractured (abundant PFs and PDFs); apparent isotropic crushing resulted in uniformly and highly dispersed orientation clusters on pole figures. Zircon grains are not abundant; however, four of 19 grains analyzed by EBSD contained {112} deformation twin lamellae, with individual lamellae ranging in length from 1 to 2 µm. Lengths of twin lamellae in Kamil zircon grains are anomalously short compared to those reported in shocked zircon from other impact structures, where individual lamellae are tens of micrometers long. Previous empirical studies have suggested that {112} twin lamellae in zircon form at ~20 GPa in non-porous target rocks, a finding supported by their coexistence, in some impactites, with high-pressure phases such as reidite. The only available experimental constraint, by diamond anvil cell, found {112} twins in zircon powder quenched at 20 GPa. The presence of coesite, stishovite, lechatelierite, and shocked quartz with PDFs in the studied sample is consistent with empirically derived pressure estimates of ~20 GPa for {112} twin formation in zircon in the ejecta sample from Kamil crater. Kamil thus represents the smallest and youngest impact structure where shock-twinned zircon has been reported. Given the apparent efficiency of {112} twin formation (21% of grains), shock-twinned zircon is here shown to provide a robust and readily identifiable record of shock deformation in a relatively common mineral at one of the smallest known terrestrial impact craters.
Return to work and sick leave patterns following a work injury among young adults: a study protocol of a Swedish multimodal study
Authors: Johansson Malin K , Hasselberg Marie , Rissanen Ritva 
Published: June 2021

IntroductionThere is a lack of studies that focus exclusively on return to work (RTW) and sick leave patterns following a work injury among young adults. This study aims to close the gap by contributing with knowledge regarding young adults’ sick leave pattern after a work injury and their experience of RTW after a work injury in Sweden.Methods and analysisThe present study is a multimodal study, which will use Swedish national register data and qualitative data collection by photovoice. Injuries classified as work injuries according to the Swedish injury classification were included. Registry data will be retrieved from the Swedish National-based registers of Swedish Information System on Occupational Accidents and Work-related diseases, the Swedish Social Insurance Agency’s database MicroData for Analysis of Social Insurance and the Swedish Longitudinal Integration Database for Health Insurance and Labour Market Studies. Persons who have registered a work injury at the Swedish Work Environment Authority in 2012 will be included. Sick leave patterns will be analysed using group-based trajectory models and multivariate analyses to explore how sick leave patterns have developed over 5 years. Subsequently, a participatory approach using photovoice method will be conducted to explore young adults’ perceptions of barriers and facilitators in RTW after a work injury. Results from the photovoice group sessions will be analysed using a grounded theoretical approach.Ethics and disseminationThe study has been reviewed and approved by the Ethical Review Board (case number 2019/028-6) in Sweden. Results of the study will be disseminated through peer-reviewed journals, print and media presentation, conferences and via reports to the funding agency.
Three-month functional outcomes following endovascular thrombectomy during the first wave of the COVID-19 pandemic: a Canadian single-center cohort study
Authors: Neves Briard Joel , Dufort Gabrielle , Jacquin Grégory , Alesefir Walid , Bereznyakova Olena , Boisseau William , Daneault Nicole , Deschaintre Yan , Diestro Jose Danilo Bengzon , Ducroux Célina , Eneling Johanna , Gioia Laura , Iancu Daniela E , Odier Céline , Raymond Jean , Roy Daniel , Stapf Christian , Weill Alain , Poppe Alexandre Y 
Published: June 2021

BackgroundThe COVID-19 pandemic has disrupted acute stroke care logistics, including delays in hyperacute management and decreased monitoring following endovascular therapy (EVT). We aimed to assess the impact of the pandemic on 90-day functional outcome among patients treated with EVT.MethodsThis is an observational cohort study including all patients evaluated for an acute stroke between March 30, 2020 and September 30, 2020 (pandemic cohort) and 2019 (reference cohort) in a high-volume Canadian academic stroke center. We collected baseline characteristics, acute reperfusion treatment and management metrics. For EVT-treated patients, we assessed the modified Rankin score (mRS) at 90 days. We evaluated the impact of the pandemic on a 90-day favourable functional status (defined as mRS 0–2) and death using multivariable logistic regressions.ResultsAmong 383 and 339 patients included in the pandemic and reference cohorts, baseline characteristics were similar. Delays from symptom onset to evaluation and in-house treatment were longer during the early first wave, but returned to reference values in the subsequent months. Among the 127 and 136 EVT-treated patients in each respective cohort, favourable 90-day outcome occurred in 53/99 (53%) vs 52/109 (48%, p=0.40), whereas 22/99 (22%) and 28/109 (26%, p=0.56) patients died. In multivariable regressions, the pandemic period was not associated with 90-day favourable functional status (aOR 1.27, 95% CI 0.60 to 2.56) or death (aOR 0.74, 95% CI 0.33 to 1.63).ConclusionIn this single-center cohort study conducted in a Canadian pandemic epicenter, the first 6 months of the COVID-19 pandemic did not impact 90-day functional outcomes or death among EVT-treated patients.
Ten‐Year Clinical Outcomes of Biodegradable Versus Durable Polymer New‐Generation Drug‐Eluting Stent in Patients With Coronary Artery Disease With and Without Diabetes Mellitus
Authors: Lenz Tobias , Koch Tobias , Joner Michael , Xhepa Erion , Wiebe Jens , Coughlan J. J. , Aytekin Alp , Ibrahim Tareq , Fusaro Massimiliano , Cassese Salvatore , Laugwitz Karl‐Ludwig , Schunkert Heribert , Kastrati Adnan , Kufner Sebastian , Byrne Robert A. , Massberg Steffen , Birkmeier K. Anette , Schulz Stefanie , Pache Jürgen , Seyfarth Melchior , Mehilli Julinda , Schömig Albert , Hoppmann Petra 
Published: June 2021

Background
Extended long‐term follow‐up data of new‐generation drug‐eluting stents in patients with diabetes mellitus is scant. The aim of this study is to assess the 10‐year clinical outcome of new‐generation biodegradable polymer‐based sirolimus‐eluting stents (Yukon Choice PC) versus permanent polymer‐based everolimus‐eluting stents (XIENCE) in patients with and without diabetes mellitus.

Methods and Results

In a prespecified subgroup analysis, outcomes of patients with or without diabetes mellitus treated with drug‐eluting stents were compared. The primary end point of this analysis was major adverse cardiac event, the composite of death, myocardial infarction, or target lesion revascularization. The analysis includes a total of 1951 patients (560 patients with and 1391 patients without diabetes mellitus) randomized to treatment with Yukon Choice PC (n=1299) or Xience (n=652). Regarding the primary end point, at 10 years patients with diabetes mellitus showed significantly higher major adverse cardiac event rates than patients without diabetes mellitus (
P
<0.001; hazard ratio [HR], 1.41; 95% CI, 1.22–1.63). There was no significant difference between patients treated with Yukon Choice PC versus Xience, neither in the subgroup of patients with (
P
=0.91; HR, 1.01; 95% CI, 0.79–1.30) nor without diabetes mellitus (
P
=0.50; HR, 0.94; 95% CI, 0.79–1.21). Rates of definite/probable stent thrombosis were 2.3% in patients with and 1.9% in patients without diabetes mellitus (HR, 1.27; 95% CI, 0.34–2.60;
P
=0.52), without significant differences between study devices.

Conclusions
The clinical outcome of patients with diabetes after percutaneous coronary intervention with different new‐generation drug‐eluting stents is considerably worse than that of patients without diabetes mellitus, with event rates constantly increasing out to 10 years.

Registration

URL:
https://clinicaltrials.gov
. Unique Identifier: NCT00598676.