bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two-stage particle separation channel based on standing wave surface acoustic wave
Authors: Chen Xueye , Zhang Yaolong 
Published: May 2021

Abstract
Microfluidic technology has great advantages in the precise manipulation of micro and nano particles, and the collection method of micro and nano particles based on ultrasonic standing waves has attracted much attention for its high efficiency and simplicity of structure. This paper proposes a two-stage particle separation channel using ultrasound. In the microfluidic channel, two different sound pressure regions are used to achieve the separation of particles with positive acoustic contrast factors. Through numerical simulation, the performance of three common piezoelectric substrate materials was compared qualitatively and quantitatively, and it was found that the output sound pressure intensity of 128°YX-LiNbO3 was high and the output was stable. At the same time, the influence of the number of electrode pairs of the interdigital transducer and the electrode voltage on the output sound wave is studied. Finally, 15 pairs of electrode pairs are selected, and the electrode voltages of the two sound pressure regions are 2.0V and 3.0V respectively. After selecting the corresponding parameters, the separation process was numerically simulated, and the separation of three kinds of particles was successfully achieved. This work has laid a certain theoretical foundation for rapid disease diagnosis and real-time monitoring of the environment in practical applications.
Threatened salmon rely on a rare life history strategy in a modified and warming landscape
Authors: Cordoleani Flora , Phllis Corey , Sturrock Anna , FitzGerald Alyssa , Whitman George , Malkassian Anthony , Weber Peter , Johnson Rachel 
Published: May 2021

Abstract
Rare phenotypes and behaviors adopted by only few individuals in a population are often overlooked, yet they may serve a heightened role for many organisms coping with warming climates. In threatened spring-run Chinook salmon spawning at the edge of the species range (Central Valley, CA USA), late-migrating juveniles were critical to cohort success in years characterized by multi-year droughts and ocean heatwaves. Late migrants rely on cool over-summer river temperatures, and are thus increasingly rare due to the combined effects of warming and dam construction. Yet our results suggest, the further loss of this within-population diversity could have critical impacts to their persistence in a warming climate. Our modeling predicts that thermally appropriate river conditions to support this phenotype will shrink rapidly in the future, and will primarily occur above impassable dams. Importantly, while late migrants dominated returns in some years, interannual variability in individual growth rates and migratory strategies suggests the importance of portfolio effects for these at-risk populations. Reconnecting and maintaining diverse habitat mosaics to support phenotypic and phenological diversity will be integral to the long term persistence of this species.
Desmoplastic fibroma of the left 6th rib in a 35-year-old man: a case report and literature review
Authors: Zhang Kai , Weibin Wu , Jiexia Guan , Yonghui Wu , Huiguo Chen , Xiaojun Li , Lijia Gu , Jian Zhang 
Published: May 2021

Abstract
Background: Desmoplastic fibroma (DF) is a rare, benign tumor. The most common sites are the long tubular bones and mandible. Although generally considered a benign tumor, it can invade surrounding tissues and has a high rate of local recurrence after incomplete surgical excision. However, there is currently no stantard treatment. Here we present a novel case of DF in the left 6th rib in a 35-year-old man.Case presentation: The man presented to our center with left chest pain and swelling. Enhanced computed tomography (CT) showed a 4.5×2.0 cm mass on the left 6th rib with pathological fracture.Wide resection was performed. Open biopsy revealed that the tumor destroyed medullary cavity and partially broke through the bone cortex. Pathologically, the tumor was composed of spindle-shaped cells arranging in a woven pattern on a backgroung of abundant collagenous fiber. No β-catenin were detected. Based on the pathological and radiological findings, a final diagnosis of DF was made. No postoperative adjuvant treatments were administerded. Fortunately, there was no evidence of recurrence 22 months after surgery. Conclusions: DF originated from rib is a kind of extremly rare benign tumor but locally aggressive and show unique biologically features. Wide resection or total resection can effectively reduce the risk of local recurrence when compared with curettage. Rarity of the tumor favors documentation in literature.
The emotional impact of the COVID-19 outbreak on cancer outpatients and their caregivers: results of a survey conducted in the midst of the Italian pandemic
Authors: Cona Maria Silvia , Rulli Eliana , Dalu Davide , Galli Francesca , Rota Selene , Ferrario Sabrina , Tosca Nicoletta , Gambaro Anna , Filipazzi Virginio , Piva Sheila , Verde Nicla La 
Published: May 2021

Abstract
INTRODUCTION The study investigates the emotional discomfort of cancer patients (pts) and their caregivers (CGs), who need to access the Oncology day-hospital to receive treatment during the COVID-19 pandemic in Italy. METHODS This is a single-institution, prospective, cross-sectional study. From May to June 2020 the points of view of both the “players” were compared through 2 different multiple-choice questionnaires, enquiring demographic characteristics, changes in emotional status, interpersonal relationships with health professionals (HCPs) and self-perception of treatment outcomes. RESULTS 625 pts and 254 CGs were enrolled. Female were prevalent and pts were generally older than CGs. 40% pts and 25.6% CGs thought they were at a greater risk of contagion because lived together with a cancer pts or accessed the hospital. Both pts (86.3%) and CGs (85.4%) considered containment measures a valid support to avoid the spread of infection . People with a lower education level were less worried about being infected with SARS-COV-2. Waiting and performing visits/treatments without CGs had no impact on the emotional status of pts (64.4%), but generated in CGs greater anxiety (58.8%) and fear (19.8%) of not properly managing pts at home . The majority of pts (54%) and CGs (39.4%) thought the pandemic doesn’t influence treatment outcomes. The relationship with HCPs was not negatively impacted for majority of pts and CGs. CONCLUSIONS Starting from these data, we can better understand the current psychological distress of pts and their families in order to develop potential strategies to support them in this strenuous period of crisis.
Assessment of heavy metal pollution resulting from informal E-wastes recycling in the Greater Accra Region of Ghana
Authors: Teye Albert Kwame , Tetteh Isaac Kow 
Published: May 2021

Abstract
This study investigated the levels and spatial distributions of four selected heavy metals in the soil and drainage components emanating from informal E-waste recycling activities at Ashaiman scrapyard, in the Greater Accra Region, Ghana. The metals are Cadmium (Cd), Chromium (Cr), Copper (Cu) and Lead (Pb). Five sampling sites were randomly selected, with top and sub-soil sampled from the two open burning areas (hereafter H and F). Three sites in the drainage that runs through the scrapyard were similarly selected for sample collection; a control upstream (soil-sediment-water; WSC) and two experimental units downstream (soil-sediment-water; WS1 and surface water only; WS2). Four control topsoil samples were taken at distances of 25, 50, 75 and 100 m away from the scrapyard. Composite sample of three sampling units per site, including pH analysis, with two replications per treatment, were investigated using standards methods. Spatial distribution of the metals in the scrapyard were analyzed using Inverse Distance Weighted (IDW) interpolation method. Coefficient of variation (CV) was used to investigate the source of pollution. The pollution levels were investigated using three criteria, namely Geoaccumulation Index (Igeo), Contamination Factor (CF) and Pollution Load Index (PLI). Correlation analysis was used evaluate the relationships between the metals. Mean CV of 88.5% suggests that the scrapyard pollution is anthropogenically-driven. Igeo of soil samples from the scrapyard revealed the following: (i) Cd and Pb (unpolluted to strongly polluted), (ii) Cu (unpolluted to moderately polluted), and (iii) Cr (unpolluted). CF revealed the following: (i) Cd (moderate to strong pollution), (ii) Cu (moderate pollution), (iii) Cr (low pollution), and (iv) Pb (high pollution), but the metals exhibited moderate PLIs. Spatial distribution maps revealed heavy metal pollution decline with distance away from the scrapyard, which was inversely related to pH levels. WSC showed lower heavy metal concentrations than WS 1, while the lowest levels were detected in WS 2. Generally, moderate to very strong correlations existed among the metals in the scrapyard. In conclusion, the scrapyard was the epicenter of E-waste pollution primarily driven by human activities.
3D Modelling Of Customized Lasts Based On Anthropometric Data Acquired From 3D Foot Scanning - One Study Case
Authors: Costea Mariana , Mihai Aura , Seul Arina 
Published: May 2021

Abstract
Designing and manufacturing personalized lasts are the first steps in obtaining the right fitted footwear for various users, especially for sport or/and medical purposes. The accurate dimensional relationship between foot and last represents the key element for this activity. The critical shape of the last should always be determined by the shape of the foot and the cumulative relationship between lengths, widths, heights and girths, whatever method is used, Some corrections and constraints must always be considered because the shoe-last is not identical to the foot. The foot anthropometric measurements are modified based on biomechanical constraints and technological limitations and they are interactively transformed into last’s dimensions by using 3D modelling. The present study brings together the modern scanning technique with the new methodology for modifying a reference last, and it is aimed to explore the philosophy of re-designing functional lasts. It also tests and highlights the limits of the actual methodology for shoe-last virtual prototyping based on anthropometric data acquired from one commercially available 3D foot scanning system.
Implementing structured follow-up of neonatal and paediatric patients: an evaluation of three university hospital case studies using the functional resonance analysis method
Authors: Bos Véronique , Roorda Daniëlle , De Sonnaville Eleonore , Boven Menne Van , Oosterlaan Jaap , Goudoever Hans Van , Klazinga Niek , Kringos Dionne 
Published: May 2021

Abstract
Background

In complex neonatal and paediatric clinical practice, little is known about long-term patient outcomes and what follow-up care is most valuable for patients. Emma Children’s Hospital, Amsterdam UMC (Netherlands), implemented a follow-up programme called Follow Me for neonatal and paediatric patient groups, to gain more insight into long-term outcomes and to use such outcomes to implement a learning cycle for clinical practice, improve follow-up care and facilitate research. Three departments initiated re-engineering and change processes. Each introduced multidisciplinary approaches to long-term follow-up, including regular standardised check-ups for defined age groups, based on medical indicators, developmental progress, and psychosocial outcomes in patients and their families. This research evaluates the implementation of the three follow-up programmes, comparing predefined procedures ( work-as-imagined ) with how the programmes were implemented in practice ( work-as-done ).

Methods

This study was conducted in 2019–2020 in the outpatient settings of the neonatal intensive care, paediatric intensive care and paediatric surgery departments of Emma Children’s Hospital. It focused on the organisational structure of the follow-up care. The functional resonance analysis method (FRAM) was applied, using documentary analysis, semi-structured interviews, observations and feedback sessions.

Results

One work-as-imagined model and four work-as-done models were described. The results showed vast data collection on medical, developmental and psychosocial indicators in all work-as-done models; however, process indicators for programme effectiveness and performance were missing. In practice there was a diverse allocation of roles and responsibilities and their interrelations to create a multidisciplinary team; there was no one-size-fits-all. Although control and feedback loops for long-term outcomes were specified with respect to the follow-up groups within the programmes, they were found to overlap and misalign with other internal and external long-term outcome monitoring practices.

Conclusion

Implementing structured long-term follow-up may provide insights for improving daily practice and follow-up care, with the precondition of standardised measurements. Lessons learned from practice are (1) to address fragmentation in data collection and storage, (2) to incorporate the diverse ways to create a multidisciplinary team in practice, and (3) to include timely actionable indicators on programme effectiveness and performance, alongside medical, developmental and psychosocial indicators.
Bioremoval mechanisms of azo dye Acid Red 14 using Wickerhamomyces anomalus yeast strain as a natural biosorbent
Authors: Danouche Mohammed , Arroussi Hicham El , Ghachtouli Naima El 
Published: May 2021

Abstract
Biosorption processes have recently become an economic and eco-friendly solution for the treatment of industrial wastewater. This study aimed to evaluate the potential application of Wickerhamomyces anomalus as a natural biosorbent for the removal of toxic synthetic dye Acid Red 14 (AR14). Biosorption kinetics modelling showed that the pseudo-second-order and intraparticle diffusion models were more suitable to fit the experimental data. In addition, the Langmuir model was the most appropriate isotherm to explain the AR14-W. anomalus biosorption system. Thus, the physicochemical properties of W. anomalus biomass before and after dye biosorption were characterized by scanning electron microscopy with energy dispersive X-Ray analysis, fourier-transform infrared spectroscopy, zeta potential, zero-point charge and contact angle measurement. The functional groups such as hydroxyl, carboxyl, amide, and amine present on the yeast wall surface can be responsible for AR14 biosorption. Finally, the Plackett-Burman design was used to screen the most influencing factors on the biosorption process, including dye concentration, dose of yeast biomass, temperature, shaking speed, and contact time. The latter was optimized according to the Box-Behnken design and the optimum AR14-biosorption was attained at pH 3–4, with lower initial dye concentrations (50–75 mg L− 1) and yeast biomass (1.25 g L− 1). These findings suggest that W. anomalus biomass could be used as an efficient, low-cost, and eco-friendly biosorbent for the removal of toxic dyes from the aqueous environment.
Ganglioside-monosialic acid (GM1) for prevention of chemotherapy-induced peripheral neuropathy: a meta-analysis with trial sequential analysis
Authors: Wu Shaoyong , Bai Xiaohui , Guo Caixia , Huang Zhimei , Ouyang Handong , Huang Jingxiu , Zeng Weian 
Published: May 2021

Abstract
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect that largely remains an unresolved clinical issue, leading to long-term morbidity. This meta-analysis aimed to evaluate the efficacy and safety of Ganglioside-monosialic acid (GM1) in preventing CIPN.Methods: Systematic literature searches of Embase, Web of Science, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were performed to identify randomized controlled trials and cohort studies that evaluated the efficacy of GM1 for preventing CIPN. Ameta-analysis was conducted to calculate odds ratios (ORs) and 95% confidential intervals (CIs) using a random-effects model. Trial sequential analyses (TSA) also were conducted to control for random errors. Results: A total of five studies involving 868 participants were included. The results showed that GM1 did not reduce the overall incidence of grade ≥2 CIPN when the common terminology criteria for adverse events (CTCAE) was used (OR 0.34, 95% CI 0.34-1.11). Subgroup analyses showed that GM1 could not reduce the risk of CTCAE grade ≥2 CIPN (OR 0.63, 95% CI 0.35-1.13) and neurotoxicity criteria of Debiopharm (DEB-NTC) grade ≥2 CIPN (OR 0.25, 95% CI 0.01-7.10) in oxaliplatin-treated patients, although GM1 might reduce the risk of CTCAE grade≥2 CIPN in the taxane subgroup in one study (OR 0.003, 95% CI 0.00-0.05). Besides, TSA suggested that the results in the taxane subgroup were robust, while that of the oxaliplatin subgroup were inconclusive. Furthermore, GM1 did not influence the rate of response to chemotherapy and CTCAE grade ≥2 adverse events such as fatigue, nausea, diarrhea, and rash.Conclusions: GM1 was not associated with a lower risk of oxaliplatin-induced peripheral neuropathy nor could improve the response or safety to chemotherapy; however, it might be able to prevent taxane-induced peripheral neuropathy. Higher-quality trials are required to clarify the preventive effect of GM1 in oxaliplatin-treated patients.
Psychometric Properties and Convergent and Divergent Validity of the Portuguese Yale Food Addiction Scale 2.0 (P-YFAS 2.0)
Authors: Gonçalves Sónia Ferreira , Moreira Célia , Machado Bárbara , Bastos Beatriz , Vieira Ana Isabel 
Published: May 2021

Abstract
Purpose The construct of food addiction has been gaining increased attention as a research topic. Currently, the Yale Food Addiction Scale 2.0 is the only measure to operationalize the addictive-like eating behavior according to addiction criteria proposed by the Diagnostic and Statistical Manual of Mental Disorders. The present study aimed at examining the psychometric properties of the Portuguese version of the Yale Food Addiction Scale 2.0, as well as investigating the convergent and divergent validity between this scale and the following measures: Eating Disorders Examination Questionnaire, Body Investment Scale, and Difficulties in Emotion Regulation Scale. We also sought to explore the moderator role of difficulties in emotion regulation in the relationship between food addiction and binge eating. Methods: A sample of 302 female college students (Mage = 21.37, SD = 3.24) completed self-report measures.Results Sixteen (5.3%) participants were diagnosed as having food addiction. The confirmatory factor analysis suggested that the original one-dimensional structure is adequate to represent the Portuguese Yale Food Addiction Scale 2.0. The symptom count scores of the scale were correlated with body mass index, eating disordered behavior, body investment and difficulties in emotion regulation. The severity level of the scale also discriminated the severity of eating disordered behaviors, body investment and difficulties in emotion regulation. Finally, the relationship between food addiction and binge eating was moderated by difficulties engaging in goal-directed behavior when experiencing negative emotions.Conclusion The Portuguese version of the Yale Food Addiction Questionnaire 2.0 may be a useful tool to investigate food addiction.
The therapeutic efficacy of fenofibrate in nonalcoholic fatty liver disease a meta-analysis of randomized controlled trials
Authors: Zhang Yongyong , Li San-Qiang , Jia Yongliang , Song Ying , Li Ji-Tian , Wang Ping , Pan Xin-Juan 
Published: May 2021

Abstract
Objective: To compare the efficacy of fenofibrate therapy in patients with nonalcoholic fatty liver disease (NAFLD) with meta-analysis of randomized controlled trials (RCTs). Method: PubMed, the Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Wang Fang Database and VIP were searched for clinical trials of fenofibrate therapy in treating patients with NAFLD. The latest search was conducted in December 1, 2020. The quality of included RCTs was assessed with the Cochrane risk of bias tool. The data was extracted and analyzed independently by two researchers. REVIEW MANAGER 5.3 was used to perform meta-analysis STATA 12.0 software was used to conduct publication bias and sensitivity analysis. And the evidence strength was evaluated with the GRADE approach. Result: 12 RCTs with 1272 patients were included. The quality of RCTs was low. The results showed that fenofibrate significantly reduced blood lipid, decreased acute inflammatory damage of liver, and improved the degree of liver fibrosis, but had no effect on insulin resistance. Sensitivity analysis indicated consistent results and there was no significant publication bias. The evidence strength was low. Conclusion: Although fenofibrate shown positive efficacy on blood lipids, liver function and liver fibrosis for patients with NAFLD, more RCTs with high quality are warranted for further evidence because of the low quality of included RCTs.
Streptomyces endocoffea sp. nov. , an endophytic actinomycete isolated from Coffea arabica (L.)
Authors: Nammali Achararak , Intaraudom Chakapong , Pittayakhajonwut Pattama , Suriyachadkun Chanwit , Tadtong Sarin , Tanasupawat Somboon , Thawai Chitti 
Published: May 2021

Abstract
An aerobic, non-motile, Gram-stain positive actinomycete, designated strain CA3R110T, was isolated from the surface-sterilised root of Coffea arabica L. collected from Lampang Province, Thailand. 16S rRNA gene sequence analysis indicated that strain CA3R110T is a member of the genus Streptomyces and showed the closest similarities to Streptomyces rapamycinicus NRRL B-5491T (99.1%), followed by S. iranensis HM 35T (99.0%). Strain CA3R110T contained LL-diaminopimelic acid in cell peptidoglycan, MK-9(H6), and MK-9(H8) as major menaquinone, iso-C16:0, iso-C15:0, C16:0 as major fatty acids. Diphosphatidylglycerol, phosphatidylethanolamine, hydroxy-phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, phosphatidylinositolmannoside were detected in the cell. The chemotaxonomic characteristics possessed the typical properties of the genus Streptomyces. A low digital DNA–DNA hybridization (< 55.6%) and average nucleotide identity-blast (ANIb) (< 92.2%) values revealed that strain CA3R110T could be distinguished from any known Streptomyces species. With the differences in phenotypic and genotypic data, strain CA3R110T represents a novel species of genus Streptomyces, for which the name Streptomyces endocoffea sp. nov. is proposed. The type strain is CA3R110T (= TBRC 11245T = NBRC 114296T).
Ceramide Levels and Covid-19 Respiratory Distress, a Causal Relationship
Authors: Khodadoust Mehran 
Published: May 2021

Abstract
A causal relationship between plasma ceramide concentration and Covid-19 patients with respiratory distress symptoms is presented. In this study, plasma samples of 52 individuals infected with Covid-19 were utilized in a lipidomic analysis. Lipids belonging to ceramide class exhibited a 400-fold increase in total plasma concentration in infected patients. Further analysis lead to demonstration of concentration dependency, for severe Covid-19 respiratory symptoms, in a subclass of ceramides. The subclasses Cer(d18:0/24:1), Cer(d18:1/24:1), and Cer(d18:1/22:0) are shown to be increased by 48, 40, and 33–folds respectively in infected plasma samples, and to 116, 91 and 50-folds in plasma samples with respiratory distress. Hence, monitoring of plasma ceramide concentration, targeting ceramide synthesis, its salvage and its regulatory mechanisms, are validated approach towards enhancing survival from Covid-19 respiratory distress.