bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hippocampus–Prefrontal Coupling Regulates Recognition Memory for Novelty Discrimination
Authors: Wang Cong , Furlong Teri M. , Stratton Peter G. , Lee Conrad C. Y. , Xu Li , Merlin Sam , Nolan Chris , Arabzadeh Ehsan , Marek Roger , Sah Pankaj 
Published: October 2021

Recognition memory provides the ability to distinguish familiar from novel objects and places, and is important for recording and updating events to guide appropriate behavior. The hippocampus (HPC) and medial prefrontal cortex (mPFC) have both been implicated in recognition memory, but the nature of HPC–mPFC interactions, and its impact on local circuits in mediating this process is not known. Here we show that novelty discrimination is accompanied with higher theta activity (4–10 Hz) and increased c-Fos expression in both these regions. Moreover, theta oscillations were highly coupled between the HPC and mPFC during recognition memory retrieval for novelty discrimination, with the HPC leading the mPFC, but not during initial learning. Principal neurons and interneurons in the mPFC responded more strongly during recognition memory retrieval compared with learning. Optogenetic silencing of HPC input to the mPFC disrupted coupled theta activity between these two structures, as well as the animals' (male Sprague Dawley rats) ability to differentiate novel from familiar objects. These results reveal a key role of monosynaptic connections between the HPC and mPFC in novelty discrimination via theta coupling and identify neural populations that underlie this recognition memory-guided behavior.SIGNIFICANCE STATEMENTMany memory processes are highly dependent on the interregional communication between the HPC and mPFC via neural oscillations. However, how these two brain regions coordinate their oscillatory activity to engage local neural populations to mediate recognition memory for novelty discrimination is poorly understood. This study revealed that the HPC and mPFC theta oscillations and their temporal coupling is correlated with recognition memory-guided behavior. During novel object recognition, the HPC drives mPFC interneurons to effectively reduce the activity of principal neurons. This study provides the first evidence for the requirement of the HPC–mPFC pathway to mediate recognition memory for novelty discrimination and describes a mechanism for how this memory is regulated.
Triglyceride glycemic index as a biomarker for gestational diabetes mellitus: a systemic review and meta-analysis
Authors: Liu Yusen , Chi Ruiwen , Jiang Yujie , Chen Bicheng , Chen Youli , Chen Zengrui 
Published: October 2021

Background
Triglyceride glycemic (TyG) index is a novel tool for assessing insulin resistance (IR). Recently, TyG index as a potential biomarker for gestational diabetes mellitus (GDM) has been studied, but its performance is yet inconclusive. Thus, we performed this systemic review and meta-analysis to evaluate the performance of TyG index in predicting GDM.

Methods
Studies published before March 1, 2021, with comparison of TyG index between GDM patients and healthy controls were retrieved from multiple databases (PubMed, Web of Science, The Cochrane Library, and Embase). The mean difference (MD) of TyG index in GDM patients and healthy controls was pooled using random-effect models.

Results
Differentiation of TyG index between patients with GDM and controls showed significant results. Overall, there is a four-fold increase in TyG index in GDM patients compared with controls (MD: 0.22, 95% CI: 0.07–0.36, P = 0.003; I2 = 71%, P = 0.009). In subgroup analyses according to gestational time, TyG index in the second trimester predicted GDM with low heterogeneity (MD: 0.26, 95% CI: 0.15–0.37, P < 0.001; I2 = 0%, P = 0.54), while no such correlation was found in the first trimester.

Conclusion
TyG index, especially in the second trimester, could be a promising biomarker for predicting GDM.
Survery of healthcare professionals to assess the awareness, knowledge and self-reported behavior regarding recent fluoroquinolones safety issues
Authors: Huruba Madalina , Farcas Andreea , Leucuta Daniel Corneliu , Sipos Mariana , Mogosan Cristina 
Published: October 2021

Background and aims. The impact of fluoroquinolone (FQ)-induced long-lasting, disabling, and potentially irreversible serious adverse drug reactions (ADRs) on the overall benefit-risk balance and the need for adequate risk minimization measures has been recently assessed. The present study aims to evaluate physicians and pharmacists' awareness and knowledge of the recent safety issues communicated through a direct healthcare professional communication (DHPC), regarding FQs, at a national level, in Romania, as well as healthcare professionals (HPs) self-reported behavior regarding the management of the risk.
Methods. Cross-sectional, online survey study, conducted in Romania.
Results. A total of 127 participants responded to the survey. Six (4.7%) were physicians and 121 (95.3%) were pharmacists. The predominant age was 31-40 years (N=52, 40.9%), and most respondents were females (N=117, 92.1%). A majority of 101 (79.5%) were reportedly aware of the existence of the new safety issues associated with FQs, and slightly less were aware of the DHPC (N=86, 67.7%) issued in 2019. In terms of knowledge, slightly more than half of the respondents had correctly selected the responses regarding key safety messages on most important ADRs and restrictions / cautions for use. The impact of the communication on HPs self-reported behavior was high or very high in almost half of the participants (N=63, 49.6%).
Conclusions. A high percentage of participants were aware of the FQ-associated safety concerns. Knowledge was relatively good for the key safety concerns among HPs. A notable impact on behavior was observed, mostly in terms of counselling of the patient and disseminating the information to colleagues.
Anatomical characteristics of myocardial loops in the adults
Authors: Dmitrieva E G , Iakimov A A 
Published: October 2021

Aim. To establish structural features and adjacent anatomy of myocardial loops in the adult and elderly human hearts.
Methods. We studied 100 hearts obtained from adult and elderly people who died from non-cardiac causes. We dissected subepicardial blood vessels and their intramural segments on 60 formalin-fixed hearts. The rate of the cone artery directly originating in the aorta (third coronary artery) was recorded. The number of myocardial loops, their localization and length were determined. We made histological sections from 40 heart specimens from areas of the coronary groove containing myocardial loops. The shortest distances from the coronary sinus and myocardium of the left atrium to the artery, the thickness of the loops, the cross-sectional area of the artery and perivascular space and the ratio of these parameters were measured. The statistical significance of differences was assessed by using the MannWhitney U-test. The relationship between the two qualitative features was identified using the Pearsons 2 test. The Spearmans rank correlation coefficient (R) was used for the correlation analysis.
Results. Macroscopically, myocardial loops were found in 12 (20%) hearts out of 60. More often, they were determined on specimens where the cone artery directly originating in the aorta. Histological examination revealed myocardial loops in 10 (25%) hearts out of 40. They were located above the arteries accompanying the coronary sinus. Their length varied from 8.5 to 44.53 mm (Me=16.68 mm), thickness from 0.16 to 0.58 mm (Me=0.31 mm). Two types of myocardial loops (arterial and arteriovenous), differing in thickness (p=0.045), were distinguished.
Conclusion. The myocardial loops are predominantly located on the diaphragmatic surface of the heart in the left half of the coronary groove over the arteries accompanying the coronary sinus, while the artery can pass in the myocardial loop separately from the veins or in the sleeve of the coronary sinus; the presence of myocardial loops is associated with the independent aortic origin of the cone artery.
Complicated destructive appendicitis: finding the optimal treatment method
Authors: Malkov I S , Mamedov T A , Shakirov M I , Filippov V A 
Published: October 2021

Aim. To analyze the current practice for the surgical treatment of destructive acute appendicitis complicated by typhlitis and periappendicular abscess.
Methods. This study analyzed the treatment outcomes in 84 patients with acute destructive appendicitis aged 18 to 79 years who were treated in the Department of Surgery No. 2 of the City Clinical Hospital No. 7 of Kazan between 2016 and 2021 years. According to the method for completion of surgical intervention, patients were divided into 2 groups, similar in age, duration of the disease and morphological changes in the appendix. In the comparison group, 54 patients had the surgical intervention completed by gauze-glove drainage of the appendix bed. In 30 patients of the main group, the appendix stump and the adjacent intestinal wall was covered with a Tachocomb plate. Then the VAC system with the Vivano device and supplies from Hartmann Group (Germany) was connected. The statistical significance of the differences between the indicators was assessed by using the Student's t-test.
Results. The analysis of the surgical techniques used showed that in the main group, postoperative wound complications decreased by 3 times (23.3% of patients, p=0.04), intra-abdominal fluid collections decreased by 2 times (6.7% of patients, p=0.02), the hospital lengths of stay decreased by 1.8 times (p=0.02) compared with the comparison group.
Conclusion. The use of ligature appendectomy in combination with plastic closure of the appendix stump with a TachoComb and the technology of local vacuum-assisted laparostomy in patients with destructive appendicitis complicated by periappendicular abscess contributes to a 3-fold reduction in wound postoperative complications and reduces the hospital lengths of stay in this group of patients by 1.8 times.
Diagnostic capabilities of the biochemical composition of amniotic fluid in assessing fetal conditions
Authors: Fatkullina I B , Lazareva A Yu , Fatkullina Yu N , Faizullina L A , Stecenko N A , Galeeva S A 
Published: October 2021

Aim. To analyze the nature of changes in the biochemical parameters of amniotic fluid during fetal hypoxia.
Methods. The study was carried out in the maternity ward of the Republican Clinical Hospital named after Kuvatov (Ufa) between January 2016 and September 2018. The main group 72 women in labor with symptoms of fetal distress, the control group 70 women in labor without it. The biochemical composition of the amniotic fluid was measured using an analyzer. Statistical analysis was performed by using the Statistica 10.0 software. Comparison of qualitative characteristics was carried out by using Fisher's exact test when comparing quantitative data, the MannWhitney test. The statistical significance of the differences was set at p 0.05.
Results. It was found that in fetal distress, there is a decrease in such biochemical indicators of the composition of amniotic fluid as the level of triglycerides (0.20.1 and 0.30.1 mmol/L, p=0.0036) and cholesterol (0.10.16 and 0.30.2 mmol/L, p=0.0275), gamma-glutamyl transpeptidase activity (34.511 and 48.76.8 U/L, p=0.0261), while the level the lactate (in the main group 3.51.2 and 3.10.9 mmol/L in the control group, p=0.0035), glucose (1.20.6 and 0.60.3 mmol/L, p=0.0002) and nitrogenous substances such as urea (4.51.1 and 3.01.3 mmol/L, p=0.0018) increases.
Conclusion. The biochemical composition of amniotic fluid reflects the state of the fetus at birth, and therefore the study of the amniotic fluid is a relevant and accessible method.
Effects of Telehomecare Interventions on the Management and Complications of Diabetes Mellitus: Protocol for a Systematic Review and Meta-Analysis
Authors: Dehghan Hamidreza , Morshediam Maryam , Dehghani Arezoo , Mirzaei Masoud , Fatehi Farhad 
Published: October 2021

Background: Diabetes is one of the most serious health challenges of the 21st century. The number of adults with diabetes has roughly tripled in the last 20 years. The increased burden of chronic diseases and scarce health resources compel healthcare systems to make modern patients more self-sufficient by requiring them to play a more active part in the treatment and management of their disease. Tele-home-care is a method of distance intervention through the transmission of electronic data for follow-up, education, prevention, clinical decision-making, and treatment modulation that has a high potential for the population with diabetes. Previous studies have not systematically evaluated the effects of different features of long-distance caregiving on diabetes at different stages of disease severity.
Objectives: The present study describes a protocol for a systematic review and meta-analysis for summarizing the evidence comparing telehomecare interventions on diabetes management and its complications.
Methods: PubMed, Scopus, ISI Web of Science, Cochrane databases, HTA (Health Technology Assessment), NHS EED (NHS Economic Evaluation Database), DARE (Database of Abstract of Reviews of Effects), Embase, and SID will be searched using medical subject heading (MeSH) keywords. Controlled clinical trials in patients with type 1 diabetes, type 2 diabetes, and gestational diabetes will be selected based on predefined eligibility criteria. The risk of bias in studies will be checked using the JADAD score. The mean difference and its standard deviation will be calculated to be used as effect size. A random-effects meta-analysis was performed to pool the results. Subgroup analysis and meta-regression will be conducted to explore the possible sources of heterogeneity.
Conclusion: The systematic review and meta-analysis provided by the results of a systematic review can be useful to endocrinologists, physicians, public health policymakers, and the general population.
A Review of Severe Acute Respiratory Syndrome Coronavirus 2 and Pathological Disorders in Patients
Authors: Ali Ghorbat Saleh , Ozdemir Betul , Selamoglu Zeliha 
Published: October 2021

Firstly, a new coronavirus emerged in Wuhan, China, sparking a pandemic of acute respiratory syndrome in humans. Corona virus disease-19 (COVID-19) was declared as a pandemic after the infection spread globally and disease caused by the new type of coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was named as COVID-19. The virus originated from bats and has been passed to humans. Initially, SARS-CoV-19 infects respiratory system an acute serious viral infection mainly developed with over a million people worldwide were transmitted rapidly in a few months. SARS-CoV-19, progress a moderate to serious severe respiratory symptoms such as headache, cough, and breathlessness. Also, digestive system symptoms include nausea, vomiting, and stomach pain. Although the precise of the mechanism of inflammation unclear but this virus firstly use the angiotensin converting enzyme 2 (ACE2) receptor of the alveolar cells of lung tissue causing inflammation and cell death. Then virus spreads and affects other important organ and tissues with complex pathophysiological alterations, the coronary disease, pulmonary disease, chronic kidney disease and chronic liver disease are the most prevalent comorbidities among patients. In COVID-19 infection therapy lots agents recommended. Unfortunately, there is no clear effective drug for treatment. This review presented potential pathogenic pathway of the SARS-CoV-19 infection and symptoms in the patients and given the information about the negative effects on different systems in the respiratory, cardiac system, nervous system, gastrointestinal system, and urinary tract.
Ocena parametrów przestrzeni porowej łupków menilitowych z odsłonięcia w Birczy
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Dudek Lidia , Ziemianin Konrad 
Published: October 2021

Celem pracy było scharakteryzowanie przestrzeni porowej łupków menilitowych występujących w odsłonięciach powierzchniowych z rejonu Birczy w jednostce skolskiej. Wszystkie próbki zostały pobrane z całego profilu stratygraficznego w jednym odsłonięciu w Birczy o długości 1 m. Struktura porowa próbek łupków wygrzanych w 105°C była mierzona metodą porozymetrii rtęciowej (ang. mercury injection capillary pressure, MICP) w temperaturze otoczenia oraz metodą adsorpcji azotu w temperaturze wrzenia ciekłego azotu. Ze względu na deformację przestrzeni porowej pod wpływem wysokich ciśnień roboczych rtęci, z krokami ciśnienia od 0 do 4136,84 bara, mikropory i mezopory można błędnie interpretować. Jako metodę uzupełniającą zastosowano więc pomiar adsorpcji azotu w celu prawidłowego obliczenia całkowitej połączonej objętości porowej. Na wykresach dV/dD (pochodnych objętości względem średnicy) połączono wyniki z obu technik pomiarowych, uzyskując pełniejszy obraz rozkładu objętości porów. W pracy przedstawiono możliwość dokładniejszego obliczenia objętości porów na podstawie nowego podejścia do analizy wykresów pochodnych. Obie metody zapewniają również kompleksową ocenę parametrów struktury porów, w tym powierzchni właściwej (ang. specific surface area, SSA), objętości mikro- i mezoporów oraz rozszerzonego zakresu rozkładu wielkości porów (ang. pore size distribution, PSD). Porównując wyniki metody adsorpcyjnej z użyciem azotu z wynikami porozymetrii rtęciowej, należy pamiętać o różnicach w zakresach obu technik badawczych oraz o tym, że azot i rtęć rejestrują struktury porowe w znacząco odmienny sposób. Zatłaczanie rtęci do struktury porowej jest regulowane przez przewężenia porów, podczas gdy zjawisko adsorpcji jest kontrolowane przez powierzchnię porów. Zastosowanie porozymetrii rtęciowej i adsorpcji azotu do łupków menilitowych pokazuje, jak użycie tych dwóch metod może wpłynąć na uzyskanie wzajemnie uzupełniających się informacji, które weryfikują obliczenia objętości porowej głównej skały macierzystej dla karpackich rop naftowych.
The Governance of Covid-19 Pandemic Health Emergency in Italy: A Constitutional Perspective
Authors: Cossiri Angela 
Published: October 2021

The essay focuses on the measures that have been taken in Italy to limit the contagion with Coronavirus in the first phase of the health emergency in 2020. The Italian Government was the first to face the epidemiological crisis in a constitutional democracy. The lockdown was one of the most drastic in Europe. On the one hand, fundamental freedoms of individuals have been compressed; on the other, the objective of limiting the expansion of the contagion in the early stage of pandemic expansion has been achieved, probably saving all European countries from an ungovernable health crisis before a minimal preparation. Even some critical aspects in the decision making process could be highlighted from a constitutional law perspective, the Author believes that the temporary measures, although drastic, not exceeded the limits allowed by the Italian Constitution, nor they seriously affected the balance between the powers at least in the first/second phase.
The majority of Parliament approved ex post the law-decrees adopted by the Council of Ministers, demonstrating that it share the Government’s political position. Furthermore, in a very short time, the Italian people, in their vast majority, spontaneously adapted to the imposed prohibitions, demonstrating a sense of responsibility and solidarity towards the most vulnerable categories with respect to the effects of the virus (elderly and sick people, for example).
The reasons of the economy, which would have required not to stop business activities, have been temporarily recessive with respect to the protection of the health of the community. This decision seems to find its ultimate foundation in the Article 2 of the Italian Constitution which requires everyone to respect the duty of social solidarity.
Kartezjusz — Lyotard — Dukaj. „Perfekcyjna niedoskonałość” jako propozycja oświecenia po uznaniu końca paradygmatu wielkich narracji
Authors: Ronge Gerard 
Published: October 2021

The paper explores the philosophical statements emerging from the plot of Jacek Dukaj’s science-fiction novel Perfekcyjna niedoskonałość [The Perfect Imperfection]. The argument of the article states that the Polish novel proposes a complete philosophical model of possible ways of imagining the future which is unique, yet fully coherent with the Enlightenment paradigm.
After recapitulating the most important arguments of the mid-century’s discussion about the end of the grand narratives and brief recall of most canonical texts of the period of the Enlightenment, the author analyses ontological presuppositions hidden after the structure of the fictional world created by Dukaj. The novel appears to fully acknowledge the Cartesian dualistic model of the human being (which strongly separates its biological and mental roots) and sets plots in times when all biological limitations have been transgressed. Despite that, both optimistic scenarios of eighteenth-century utopians and catastrophic visions of twentieth-century sci-fi authors have never been fulfilled and the fictional world of the twenty-ninth century appears to be just the same as ours in its core, despite being totally different in terms of its phenomenological appearance.
Jaki kraj, taki Superman
Authors: Szyłak Jerzy 
Published: October 2021

No hero similar to Superman could have appeared in communist Poland, as he represented the power of individualism and followed his own feelings of justice. Meanwhile, the communists expected one to act in a collectivity fully subordinate to the official government. This deficiency was compensated by superhero parodies. One should firstly enumerate the TV film Hydrozagadka, about a hero, who had no drawn equivalent, though he was a mockery of the comic book poetics and of the simplifications it conveys.
After the communist system fell, other superhero parodies appeared, such as Ratman, Strain, Milkyman and Wilq. Also, Likwidator by Ryszard Dąbrowski constituted irreverent and mischievous comment to political events in Poland. Only later did serious superhero stories essays appear: Bler by Rafał Szłapa, Biały Orzeł by Adam Kmiołek and Jan Hardy by Jakub Kijuc. These authors take their heroes very seriously but readers can find much irony in the stories.