bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of RB1 Gene as a Immune-Related Prognostic Signature Based on Tumor Mutation Burdens in Bladder Cancer
Authors: Chen Ming , Cheng Hong , Wu Tiange , Gui Zeping , Gao Ying , Gan Xinqiang , Xu Bin 
Published: April 2021

Abstract
Background: Bladder cancer (BC) is known as the eleventh most common malignant tumor all over the world, for either males or females. Developing effective regimens targeting more promising biomarkers aiming for better prognosis are required. Immune checkpoint inhibitors (ICI) have been demonstrated as a prospective and practical means to resist cancers. Theoretically, adequate infiltration of immune cells indicates more immunotherapy targets and may promise better prognosis.Methods: Full transcriptome data (n=433), clinical information (n=581) and mutation sequencing (n=412) were obtained freely from The Cancer Genome Atlas and independent mutation sequencing data of 101 samples were acquired from International Cancer Genome Consortium. Statistical processing was conducted using R packages with R x64 4.0.2. Gene biologically functional research was performed with gene set enrichment analysis (GSEA) based on Kyoto Encyclopedia of Genes and Genomes (KEGG) database. 22 types of immune cell infiltration were assessed and calculated in 398 samples of BC tumors.Results: Tumor mutation burdens (TMB) of mutant type groups were higher than wild type groups for 19 genes, except for FGFR3 and CREBBP verifying that genomic mutation associates positively with TMB in BC tumor. Kaplan-Meier analysis showed high mutation frequency on RB1 had a negative effect on prognosis of BC patients and RB1 was an independent prognostic factor (p=0.004, HR=1.776) in BC. It was also demonstrated that RB1 mainly participate in singling pathways of cell proliferation and cell cycle. Proportions and correlation of 22 types of immune cells in 433 samples were determined. Immune cells with similar function are inclined to co-exist in tumor microenvironment of BC. Among them, regulatory T cells (Tregs) were detected as a negatively correlated type immune cell to mutation of RB1 that probably increases the incidence of tumor immune escaping in BC.Conclusion: RB1 can be identified as an independent prognostic predictor, and there is a chance for contribution to poor overall survival as the mutation occurs. What's more, mutation of RB1 also functions as a biomarker that represses the infiltration of Tregs, increasing the incidence of tumor immune escaping in BC.
Correlation between Low-Level Viremia and Hepatitis B-Related Hepatocellular Carcinoma and Recurrence: A Retrospective Study
Authors: Sun Furong , Liu Zhifei , Wang Bingyuan 
Published: April 2021

Abstract
Background

Low-level viremia generally refers to detectable HBV DNA levels lower than 2,000 IU/mL. Studies show that low-level viremia is a risk factor for hepatocellular carcinoma. The aim of this study was to explore the characteristics of low-level viremia patients with hepatitis B-related hepatocellular carcinoma and identify patient prognostic factors following curative hepatectomy.
Methods

Data from chronic hepatitis B patients with hepatocellular carcinoma receiving curative hepatectomy for the first time in the first hospital of China Medical University were studied. Patients were divided into two groups based on preoperative HBV DNA levels: group 1 (low-level viremia group, HBV DNA < 2,000 IU/mL) and group 2 (HBV DNA ≥ 2,000 IU/mL).
Results

Of the 212 patients, 104 patients were in group 1 and 108 patients were in group 2. There was a lower proportion of patients with HBsAg levels > 250 IU/mL in group 1 than in group 2 (71.2% vs. 86.1%, P < 0.01). The proportion of patients with a tumor diameter < 5 cm was 67.3% in group 1 and 37.0% in group 2 (P < 0.000). Tumor recurrence was 40.4% (42) in group 1 and 54.6% (59) in group 2 (P < 0.05). Median recurrence-free survival was 30.1 months in group 1 and 17.6 months in group 2 (P < 0.01). Multivariate analysis showed that a tumor diameter > 5 cm (hazard ratio [HR] = 1.819, 95% confidence interval [CI] 1.193–2.775, P = 0.005), intrahepatic metastasis (HR = 1.916, 95% CI 1.077–3.407, P = 0.027), and an HBV DNA level > 100 IU/mL (HR = 2.943, 95% CI 1.916–4.520, P < 0.000) were independent prognostic factors associated with an increased risk of hepatocellular carcinoma recurrence.
Conclusion

Preoperative low-level viremia was related to a long tumor recurrence interval and post-operative virologic response was associated with a lower risk of hepatocellular carcinoma recurrence.
Comparison of Radiofrequency Ablation with or without Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Meta-Analysis of Randomized Controlled Trials
Authors: Wang Xinxin , Che Yang , Chen Shiyong , Wu Biao , He Yu , Dong Baolong , Yang Xiaojun 
Published: April 2021

Abstract
Background

To evaluate the curative effect and safety of compare radiofrequency ablation (RFA) with or without transcatheter arterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma (HCC)with the help of a meta-analysis of randomized controlled trials (RCTs) .
Materials and Methods

RCTs comparing TACE combined with RFA and RFA alone were searched electronically using PubMed, The Cochrane Library, and EMBASE. Fixed and random-effects were used to measure pooled estimates. Research indicators included overall survival (OS), recurrence-free survival (RFA), tumor progression and complications.
Results

Overall, 6 RCTs were included in this meta-analysis, with a total of 527 patients (TACE-RFA: 271; RFA: 256). 3- and5-year OS rate was higher in the TACE-RFA group than in the RFA group (OR = 1.74; 95% CI: 1.17–2.59; p = 0.006; OR = 2.19; 95% CI: 1.49–3.22; p < 0.0001). The 3- and 5-year RFS rate in the TACE-RFA group was higher than that in the RFA group (OR = 1.92, 95% CI: 1.30 ~ 2.82, p = 0.0009; OR = 1.81, 95% CI: 1.21 ~ 2.70, p = 0.004, respectively). The rate of tumor progression was lower in the TACE-RFA group than in the RFA group (OR = 0.57; 95% CI: 0.38 ~ 0.85; p = 0.005). No significant differences in terms of 1-year OS rate and complications rate were observed between groups.
Effects on oxygenation and tissue perfusion of preoperative administration of levosimendan in hip fractures and left ventricular dysfunction&nbsp;
Authors: Lorenzo María C Martín 
Published: April 2021

Abstract
Background: Hip fracture is common in elderly and has high morbidity and mortality. Many present left ventricular dysfunction, the use of inotropics may reduce perioperative cardiovascular complications. The objective of this study is to evaluate the safety and efficacy of a perioperative hemodynamic optimization protocol based on goal-guided therapy with levosimendan in these patients.Methods: In this prospective study 19 patients with LVEF <45% were recruited forhip surgery. They received an infusion of levosimendan 24h (0.1μg/kg/min) before surgery. Hemodynamic, oxygenation, tissue perfusion and analytical parameters; and ultrasound measurements of cardiac function were obtained before and at 24, 48 hours and 7 days later.Results: Patients mean age was 86±7 years. Both cardiac index, from 2.9±0.6 L.min–1m–2 at baseline to 3.7±0.8 L.min–1m–2 (P <0.001) and stroke volume index, from 36 ± 10 to 44 ± 8 mL/ m–2 (P =0.003) increased significantly at 24 h after drug initiation and remained significantly increased for 48 h. Systemic vascular resistance index decreased significantly (from 2302 ± 726 dyn.s.cm–5 m–2 to 1676 ± 530 dyn.s.cm–5 m–2 , P <0.001). Ejection fraction and left ventricular outflow tract velocity time integral also increased without reaching significance. A decrease in the NT-proBNP values was observed without statistical significance. Troponin I decreased non-significant until day 7, from 0.143 ± 0.42 pg/mL to 0.113 ± 0.15 pg/mL (P=0.17). DO2 increased significantly in parallel to CI from 751 ± 196 mL/min to 854 ± 340 mL/min (P =0.04) at 48 h, while O2 ER decreased significantly during infusion, 36 ± 7% to 32 ± 8% (P =0.04) ScvO2 significantly increased from 61 ± 7% to 69 ± 8% (P =<0.001) 48 h after infusion.Conclusions: The implementation of a preoperative optimization protocol based on goal-directed therapy with levosimendan in patients with left ventricular dysfunction and hip fractures did not present major complications. An improvement in perioperative haemodynamic parameters and also in the balance between oxygen delivery and consumption at tissue level was found. Levosimendan decreased mortality a year with respect to a retrospective case registry
Multi-stage magma evolution recorded by apatite and zircon of adakite-like rocks: A case study from the Shatanjiao intrusion, Tongling region, Eastern China
Authors: Cao Jingya , Li Huan , Yang Xiaoyong , Tamehe Landry Soh , Esmaeili Rasoul 
Published: April 2021

Abstract
The Shatanjiao pluton, located in the eastern Tongling region (Eastern China), is of great research significance for the study of magma evolutionary processes because this pluton is related to the regional Cu-Au mineralization. Zircon U-Pb dating on two granodiorite samples from this pluton yields ages of 141.9 ± 3.1 Ma (MSWD = 0.07) and 141.9 ± 3.3 Ma (MSWD = 0.03), respectively, which overlap the range of intense Late Jurassic to Early Cretaceous magmatism in the Tongling region. Based on the Sr content of apatite from the Shatanjiao granodiorites, they are subdivided into high-Sr apatite (apatite-I: 754–1242 ppm, mean = 1107 ppm) and low-Sr apatite (apatite-II: 415–613 ppm, mean = 507 ppm). Both apatite-I and apatite-II are characterized by high-Sr and -Sr/Y ratios and inconspicuous negative-Eu anomalies, indicating that these granodiorites have a likely adakite affinity. Considering their low-Rb contents (&lt;0.05 ppm), in situ Sr isotopes of these apatite grains show 87Sr/86Sr ratios of 0.70848–0.71494 and 0.70767–0.71585 for apatite-I and apatite-II, respectively, indicating that the 87Sr/86Sr ratios of both apatite groups can represent the Sr isotopic compositions of their host rocks. Moreover, the La/Sm and Sr/Th ratios of both apatite groups suggest that the studied granodiorites might be sourced from the partial melting of subducted ocean slabs and overlying sediments. Based on their zircon trace element compositions, the calculated temperature and oxygen fugacity for the magma are characterized by high temperatures (mean T = 646 °C) and high oxygen fugacity (mean Ce4+/Ce3+ ratios = 341). On the basis of MgO, FeO, SiO2, and ΣREE contents of apatite, we further suggest that apatite-I and apatite-II might have crystallized at the early and late stages of magma evolution, respectively. Because apatite-I has much higher Eu/Eu* ratios (0.56–0.76) but lower (La/Yb)N ratios (7.85–28.6) than apatite-II of 0.39–0.58 and 95.9–132, respectively, it is indicated that plagioclase, garnet, hornblende, and zircon might control the trace element composition of melt during the magma evolutionary history, which were recorded by the apatite. Therefore, apatite can be an ideal tracer to reflect the sequence of multistage magma evolution.
El suicidio como riesgo asegurable en Colombia: Un análisis jurisprudencial a partir de la teoría del precedente judicial
Authors: Amaya Suárez Mario Alberto 
Published: April 2021

El presente trabajo busca realizar un análisis del suicidio como riesgo asegurable a partir de una sentencia proferida en el año 2018, por la Sala de Casación Civil de la Corte Suprema de Justicia. Lo anterior se aborda a partir de la concepción del precedente en la tradición jurídica de Colombia y de la realización de un análisis jurisprudencial estático. La finalidad del trabajo radica en identificar los alcances de la decisión proferida por la Corte Suprema de Justicia y reflexionar sobre la aplicación de la figura del precedente en la sentencia analizada. Para ello se implementó una metodología dogmática basada en el análisis de normativo, jurisprudencial y doctrinal sobre los temas que se abordan. El trabajo logra reflexionar, en primer lugar, sobre el alcance de la sentencia proferida por la Corte y, en segundo lugar, sobre los problemas de la aplicación del precedente judicial en Colombia.
COVID-19 y diabetes. Retos, Implicaciones y manejo durante la pandemia
Authors: Torres-Grajales José Luis , Aristizábal-Henao Natalia , González-Hurtado Daniel , Aguilar-Londoño Carolina , Blanco Víctor M. 
Published: April 2021

Desde finales del año 2019 un nuevo coronavirus, SARS-CoV-2, se extendió desde China hacia el resto del mundo, causando la pandemia de una enfermedad denominada COVID-19. Una enfermedad sistémica que en algunos casos produce neumonía severa que incluso puede progresar a falla respiratoria aguda y finalmente la muerte. Entre las comorbilidades que se han asociado con un aumento en la mortalidad por SARS-CoV-2 se encuentra la diabetes. En general, se estima que tener diabetes aumenta un 18 % el riesgo de infecciones respiratorias, en parte por el impacto que genera sobre la inmunidad innata o adquirida, lo que estaría contribuyendo a una presentación clínica más severa del SARS-CoV-2 al comparar con población sin diabetes. Considerando que existe una asociación entre mal control glucémico y mayor severidad clínica de la infección por COVID-19, se deben hacer importantes consideraciones sobre el manejo farmacológico brindado a los pacientes; el perfilamiento dependerá de las condiciones de cada paciente, de la severidad de la enfermedad y del tipo de manejo instaurado ya sea ambulatorio o intrahospitalario.
Impacto de COVID-19 en la enfermedad cardiovascular
Authors: Ramírez-Ramos Cristhian Felipe , Vanegas Diego Mauricio , Ramírez Méndez Diego A , Castilla Agudelo Gustavo Adolfo , Aranzazu Uribe Mateo , Fernández Ruiz Ricardo , Uribe Londoño Carlos Esteban , Ocampo Aristizabal Luz Adriana , Quintero Ossa Alvaro Mauricio , Gallego Catalina , Saldarriaga Giraldo Clara Inés 
Published: April 2021

La enfermedad por coronavirus-2019 (COVID-19) es una enfermedad infecciosa cuya sintomatología inicial, en la mayoría de las ocasiones, se manifiesta con compromiso del tracto respiratorio. El virus que causa dicha enfermedad se denomina síndrome respiratorio agudo severo por coronavirus 2 (SARS-CoV2). Si bien la manifestación grave más frecuente de la infección parece ser la neumonía, se han documentado diversas implicaciones cardiovasculares. Las personas que cursan con dicha infección y que tienen una enfermedad cardiovascular preexistente tienen un riesgo mayor de cuadros graves y mortalidad. Existen asociaciones directas o indirectas de la infección con injuria miocárdica, arritmias, enfermedad tromboembólica venosa y miocarditis. Los tratamientos en investigación pueden tener efectos adversos en el sistema eléctrico del corazón; además, algunos medicamentos de uso crónico (como los inhibidores del sistema renina angiotensina aldosterona) se les ha otorgado un polémico papel en la virulencia del microorganismo. La alta demanda en atención en salud que requieren los pacientes infectados por SARS-CoV 2 puede comprometer la asistencia de pacientes cardiovasculares sin dicha infección y dejar en riesgo de exposición al personal sanitario. Se presenta una revisión sobre los aspectos más llamativos donde estas dos condiciones interaccionan.
Inteligencia Emocional y practica clínica en tiempos de pandemia
Authors: Sierra Sara , Diaz-Castrillon Carlos Eduardo 
Published: April 2021

Los cambios generados por la pandemia COVID-19 han significado innumerables retos en la práctica clínica, en los que el personal de salud ha tenido que adaptarse profesional y emocionalmente. Fortalecer la inteligencia emocional en los profesionales de la salud contribuye a su bienestar personal, previene el síndrome de burnout y ayuda a la creación de ambientes laborales seguros, objetivos fundamentales a la hora de enfrentar desafíos como la pandemia actual. Cuatro habilidades de la inteligencia emocional que son particularmente importantes en la práctica clínica (autoconciencia, autorregulación, conciencia social y manejo de relaciones) son objeto de reflexión en el presente artículo.
Factors Associated with Primary Hypertension in Pediatric Patients: An Up-to-Date
Authors: S. Machado Isabella Barreto , Tofanelli Matheus Rampinelli , Saldanha da Silva Ariadna A. , Simões e Silva Ana Cristina 
Published: April 2021

Background:
Arterial hypertension in children is considered a common alteration nowadays,
mainly because obesity is a growing worldwide problem closely related to increased blood
pressure. Childhood hypertension can be classified as primary or secondary, depending on the etiology.
Primary or essential hypertension still has its pathophysiology not fully elucidated, and there
is no consensus in the literature on most underlying mechanisms. In this review, genetic and environmental
factors, including sodium and potassium intake, socioeconomic status, ethnicity, family
structure, obesity, sedentary lifestyle, prematurity and low birth weight, prenatal and postnatal exposures
are highlighted.

Objective:
The present study aimed to perform an update on primary hypertension in childhood,
providing clinicians and researchers an overview of the current state of the literature regarding the
influence of genetic and environmental factors.

Methods:
This integrative review searched for articles on genetic and environmental factors related
to primary hypertension in pediatric patients. The databases evaluated were PubMed and Scopus.

Results:
The studies have provided insights regarding many genetic and environmental factors, in
addition to their association with the pathophysiology of primary hypertension in childhood. Findings
corroborated the idea that primary hypertension is a multifactorial disease. Further studies in
the pediatric population are needed to elucidate the underlying mechanisms.

Conclusion:
The study of primary hypertension in pediatrics has utmost importance for the adoption
of preventive measures and the development of more efficient treatments, therefore reducing
childhood morbidity and the incidence of cardiovascular diseases and other health consequences
later in life.
Suicidal Ideation among People with Depression in Mental Hospital, Kabul-Afghanistan
Authors: Dahlan Akehsan , Shahid Mahjabin , Masuri Mohamad Ghazali 
Published: April 2021

Depression affects one's feeling and thinking, leading to a persistent feeling of sadness and loss of interest in activities. Depression could lead to suicidal ideations, decrease a person's ability to functions and quality of life. A cross-sectional study was conducted to 143 samples to determine the relationship between demographic variables, depression, suicidal ideation, social support and distress. The findings show that the level of suicidal ideation is high, and there is a relationship between variables under study. The main predictors of the suicidal ideation were the high level of distress and low social support level among the study participants.
Keywords: Depression; suicidal ideations; mental health
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i16.2619
Assessment of the Effectiveness of Identity-Based Public Health Announcements in Increasing the Likelihood of Complying With COVID-19 Guidelines: Randomized Controlled Cross-sectional Web-Based Study
Authors: Dennis Alexander S , Moravec Patricia L , Kim Antino , Dennis Alan R 
Published: April 2021

Background
Public health campaigns aimed at curbing the spread of COVID-19 are important in reducing disease transmission, but traditional information-based campaigns have received unexpectedly extreme backlash.

Objective
This study aimed to investigate whether customizing of public service announcements (PSAs) providing health guidelines to match individuals’ identities increases their compliance.

Methods
We conducted a within- and between-subjects, randomized controlled cross-sectional, web-based study in July 2020. Participants viewed two PSAs: one advocating wearing a mask in public settings and one advocating staying at home. The control PSA only provided information, and the treatment PSAs were designed to appeal to the identities held by individuals; that is, either a Christian identity or an economically motivated identity. Participants were asked about their identity and then provided a control PSA and treatment PSA matching their identity, in random order. The PSAs were of approximately 100 words.

Results
We recruited 300 social media users from Amazon Mechanical Turk in accordance with usual protocols to ensure data quality. In total, 8 failed the data quality checks, and the remaining 292 were included in the analysis. In the identity-based PSA, the source of the PSA was changed, and a phrase of approximately 12 words relevant to the individual’s identity was inserted. A PSA tailored for Christians, when matched with a Christian identity, increased the likelihood of compliance by 12 percentage points. A PSA that focused on economic values, when shown to individuals who identified as economically motivated, increased the likelihood of compliance by 6 points.

Conclusions
Using social media to deliver COVID-19 public health announcements customized to individuals’ identities is a promising measure to increase compliance with public health guidelines.

Trial Registration
ISRCTN Registry 22331899; https://www.isrctn.com/ISRCTN22331899.
COMPREENSÃO DO PROCESSO DE APRENDIZAGEM: as contribuições da Neuroeducação
Authors: Costa Claudio , Nóbile Márcia , Crespi Lívia Regina Saiani 
Published: April 2021

O artigo objetiva investigar como se dá a compreensão do processo de aprendizagem segundo as contribuições da neuroeducação, haja vista a necessidade de estratégias didáticas que respeitem as especificidades de cada aluno e que promovam condições para que estes avancem em seus processos de aprendizagem. Assim, esse estudo se desenvolveu a partir de uma revisão de literatura científica em artigos publicados entre janeiro de 2009 a janeiro de 2019, na base de dados SciELO. Além desses estudos, também livros sobre o tema foram utilizados para a estruturação do artigo. O período do estudo transcorreu de setembro de 2009 a dezembro de 2019. Com essa revisão de literatura, percebe-se uma convergência entre os estudos dos diversos autores que apontam que os estudos de neuroeducação podem auxiliar no desenvolvimento de estratégias que auxiliam o aluno em sua aprendizagem e com embasamento científico, sobretudo respeitando a forma como o cérebro funciona. O estudo também aponta que os conhecimentos agregados às neurociências podem contribuir substantivamente para a educação e, ainda, melhorar a qualidade de vida do indivíduo e da sociedade.