bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Redesign of a Clinical Decision Allergy and Drug Interactions Alerts in an Electronic Prescribing System on Patient Safety – A Quantitative Descriptive Study
Authors: Khalil Viviane , Hua Amanda 
Published: November 2021

ABSTRACT

Background:
Electronic medication management systems (EMS) generate medication alerts such as Drug-Drug interaction (DDI) and allergy at the drug order entry point for clinicians to improve patients’ safety. EMS that provide non-clinically significant alerts contribute to alert fatigue and pose a risk for patients’ harm. The primary aim is to assess the impact of redesign of allergy and DDI alerts on alerts’ trigger and overrides rates. The secondary aim is to assess the impact of the redesign of the alerts on reported patients’ harm.

Methodology:
A retrospective cross sectional 2 stage study was conducted. Stage 1 involved analysis of inpatients’ electronic drug orders in the hospital’s EMS that triggered an allergy, or a DDI alert from October to December 2019 in a 650 bed Australian hospital. A report on the 50 commonly overridden allergy and DDI alerts was reviewed by a multidisciplinary team to assess the clinical significance of the alerts using a risk matrix tool, frequency of overrides as well as published literature on adverse effects. Subsequently, non-clinically significant allergies and DDI alerts were deactivated in EMS system in March 2020. Stage 2 of the study involved the same analysis conducted in stage 1 (March to May 2021). The number of alerts overrides, alert trigger rates and number of related reported incidents involving patients’ harm were analysed.

Results:
A total of 288,267 and 288,133 prescriptions orders were reviewed in the 2 stages respectively. A total of 12 DDI and 37 allergy alerts were deactivated in stage 2. Redesign of the alerts reduced the trigger rate of allergy alerts (4.96% to 3.77%, P < 0.0001) and DDI alerts (5.30% to 4.73%, P < 0.0001). A statistically significant reduction in the number of incidents with reported patients’ harm related to overrides of alerts was observed in the post intervention phase. The allergy alert trigger rate was reduced from 4.96% to 3.77%, P = 0.0172.

Conclusion:
The study demonstrated that using an evidence-based approach and a risk assessment matrix to deactivate non-clinically significant alerts potentially contribute to a decrease in patients’ harm.

Highlights
Immunopathogenesis and immunotherapeutic approaches of neurodegenerative and cerebrovascular diseases with cognitive impairment. The current state of the problem and prospects
Authors: Smirnova A. A. , Prakhova L. N. , Ilves A. G. 
Published: November 2021

Cognitive impairments (CI) are a serious problem in modern society, because they significantly reduce patients’ quality of life and tend to progress. Age-related diseases such as neurodegenerative — first of all Alzheimer’s disease (AD) and cerebrovascular disorders are key causes leading to CI. At present, approaches to treating these diseases have limited eﬀectiveness in restoring cognitive functions, and do not change disease course, although they can slow cognitive decline.Understanding the immunopathogenesis of neurodegenerative and cerebrovascular diseases defines new targets and approaches to their treatment. In addition, suppression of neuroinflammation is advisable in the cases of early nonclarified cognitive decline, when information from routine medical, laboratory and instrumental examination of patients is insuﬃcient to identify the causes of CI.This article summarizes current understanding of the immunopathogenesis of AD and chronic cerebral ischemia. The mechanism of neuroinflammation is presented as a cascade of sequential events that are closed in a self-perpetuating inflammatory response in the end. So called damage-associated molecular patterns, specific receptors that can bind them (pattern recognition receptors), intracellular signal transduction in microglia, cytokines and adhesion molecules are considered as potential points of application of immunomodulatory therapy. The review provides information on the current level of development of immunotherapy of AD, chronic cerebral ischemia and oﬀers the prospect of its application.
The use of the monoclonal antibody Erenumab in patients with chronic migraine in real clinical experience
Authors: Ekusheva E. V. , Artemenko A. R. , Shirshova E. V. , Sokov P. E. , Plieva A. M. 
Published: November 2021

Patients with chronic migraine are characterized by frequent severe headache attacks, polypharmacy (painkillers), insuﬃcient eﬀect of preventive therapy, and a decrease in the quality of life. The aim of a prospective open-label study was the evaluation of the eﬃcacy and tolerance of Erenumab (Irinex) in the treatment of patients with chronic migraine in real clinical practice.Material and methods. 48 patients with chronic migraine were clinically and neurologically examined (35.5 [19; 56]; diagnosis was established according to the criteria of ICHD classification and diagnosis of migraine. Medical monitoring period was 3 months. Clinical and neurological testing and subcutaneous administration of Erenumab (Irinex) 70 mg were performed once a month during the whole period.Results. Safety, good tolerance and an obvious significant clinical eﬀect were noted when using Erenumab (Irinex) 70 mg. It led to a significant improvement in clinical score and the course of chronic migraine, the eﬀectiveness of rapid relief of symptoms and significant reduction in the need for painkillers in most patients. The best results were found after 3 months of therapy.
PENENTUAN PENGGUNAAN LAHAN GAMBUT UNTUK PENINGKATAN EKONOMI MASYARAKAT DI KABUPATEN INDRAGIRI HULU
Authors: Zamaya Yelly , Tampubolon Dahlan , Misdawita Misdawita 
Published: November 2021

Sustainable peatland management will have an impact on the welfare of the community as a whole. Rural communities use peatlands as their primary source of income. This article aims to formulate plants on peatlands to improve the economy of the community Indragiri Hulu Regency. The method used is a combination of field observation data and a participatory geographic information system (GIS-P). The utilization of peatlands is still dominated by oil palm and rubber plants. Peatlands have the potential for high-value and environmentally friendly vegetation, such as gaharu, barley and liberica coffee. The shallower peatlands are suitable for horticultural vegetation such as rice and short-lived vegetables and fruits. Besides, it is reasonable to cultivate wetlands in Indragiri Hulu, such as catfish, catfish, tilapia and tilapia. Through this participatory information system, it is possible to determine the commodities developed in the region.
POTENSI RUANG SEMPADAN SUNGAI UNTUK PEMENUHAN KEBUTUHAN RUANG TERBUKA HIJAU TAMAN KOTA SEMARANG
Authors: Kautsary Jamilla kautsary , Rahman Boby , Shafira Salmaa 
Published: November 2021

Ruang Terbuka Hijau (RTH) di perkotaan keberadaannya sangat penting tidak hanya dari sisi estetik, dan ekologis, tetapi juga secara sosial dan ekonomi. Keberadaan ruang ini, menjadi sangat langka dan sulit untuk dipenuhi, akibat kurangnya langkanya lahan di perkotaan. Upaya pemenuhan RTH secara umum hanya didasarkan pada pertimbangan pemenuhan angka 30% luas perkotaan dengan perincian 20% publik dan 10% RTH privat, tanpa melihat detailnya sesuai dengan pedoman teknis yang berlaku di Indonesia. Kajian potensi RTH sempadan sungai ini berlokasi di Kota Semarang, dengan pendekatan perhitungan terinci sesuai standar Peraturan Menteri Pekerjaan Umum No. 5 Tahun 2008. Identifikasi luasan dibantu dengan alat analisis GIS yang di triangulasikan dengan data primer dan sekunder. Hasil perhitungan yang menunjukkan ada potensi yang cukup besar untuk RTH sempadan sungai sebesar 11,95% (dari yang seharusnya 1,5% bersama RTH fungsi tertentu lainnya). Potensi kelebihan ini sebagian tentu bisa dimanfaatkan untuk pemenuhan RTH taman kota yang saat ini capaiannya rata-rata hanya sebesar 3,776% dari 12,5% yang di tentukan.
POLA RUANG EKONOMI DI KAWASAN PINGGIRAN PERKOTAAN
Authors: Yuliani Eppy , Karmilah Mila , Ridlo M. Agung 
Published: November 2021

ABSTRACTThe development of the center of the city of Semarang is very rapid, leading to the outskirts. The outskirts, which were originally used as agricultural areas, have now been converted into built-up areas, settlements, trade and services. This research was conducted in Tembalang Village, which is an educational area, new settlements accompanied by the growth of economic activity. The purpose of this study is to find patterns of economic space in suburban urban areas. Methodology Descriptive analysis research using a qualitative and rationalistic deductive approach that focuses on the environmental approach (behavior approach) and the spatial economic approach. From the results of the analysis, it is concluded that Tembalang Village has an Economic Spatial Pattern that develops along the main road. Economic activities that follow this main road route form a network pattern. This pattern of economic space is also still visible in the surrounding area. The pattern of economic space that develops on the main road corridor has a high selling value of land. Every year there is an increase in land prices, both according to NJOP, land rental prices and land selling prices.Keywords: pattern, space, economy, activity, suburbs, urban. ABSTRAKPerkembangan pusat Kota Semarang yang sangat pesat, mengarah pada kawasan pinggiran. Kawasan pinggiran yang awalnya sebagai fungsi kawasan pertanian, banyak beralih fungsi menjadi kawasan terbangun, pemrmukiman, perdagangan dan jasa. Penelitian ini dilakukan di Kelurahan Tembalang, yang merupakan kawasan pendidikan, permukiman baru disertai dengan pertumbuhan aktivitas ekonomi. Tujuan penelitian ini menemukan pola ruang ekonomi pada kawasan pinggiran perkotaan. Metodologi Penelitian analisis deskriptif dengan menggunakan pendekatan deduktif Kualitatif Rasionalistik yang berfokus pada pendekatan lingkungan (behaviour approach) dan pendekatan ekonomi keruangan (spatial economic approach). Dari hasil analisis disimpulkan Kelurahan Tembalang memiliki Pola Ruang Ekonomi yang berkembang di sepanjang jalan utama. Kegiatan perekonomian yang mengikuti jalur jalan utama ini mementuk pola jaringan. Pola ruang ekonomi ini juga masih terlihat pada kawasan sekitarnya. Pola ruang ekonomi yang berkembang pada koridor jalan utama, memiliki nilai jual lahan yang tinggi. Semakin tahun mengalami kenaikan harga lahan baik menurut NJOP, harga sewa lahan maupun harga jual lahan.Kata kunci : pola,ruang, ekonomi, aktivitas, pinggiran, perkotaan.
IMPLEMENTASI SISTEM PELAPORAN SARANA DAN PRASARANA KEGIATAN BELAJAR MENGAJAR BERBASIS ANDROID (STUDI KASUS : INSTITUT INFORMATIKA DAN BISNIS DARMAJAYA)
Authors: Sari Yuni Puspita , Ali Rionaldi 
Published: November 2021

Informatics and Business Institute Darmajaya is one of higher education institute that conduct quality standard in service area. Acknowled gement to the service proven by ISO 9001:2015 certificate issued by International Standard Organization since 2008. One of standard in our quality standard is concern about the quality of service, and impremented in the form of fascility monitoring in Darmajaya campus. Facilities and infrastucture particulary classromm and laboratorium which is the main aspect in the learning process between lecturer and student to conduct course interaction.This application designed to build a system to collect complaint report that could help to support course interaction. Prototype model used in the design of these system.Our reseach has been resulting and application to collect complaint report about facilities and infrastucture than run on android based system. The application give support to process the report and also complaint system information. We concluded that our system can be use for real-time monitoring for facilities and infrastucture. Keywords: Facilities and Infrastructure, Complaint Report Information System, Android Base.
SISTEM PENDUKUNG KEPUTUSAN PEMILIHAN KONSENTRASI BIDANG ILMU EKONOMI MENGGUNAKAN METODE WEIGHTED AVERAGE DAN FUZZY FIS TSUKOMOTO ( Studi Kasus Program Magister Manajemen IIB Darmajaya )
Authors: Mutiara Suci , - Yulmaini , Aziz RZ Abdul 
Published: November 2021

Postgraduate IIB Darmajaya in Management program in its curriculum offers concentration subjects in the third semester. Concentrations in the field of economics are grouped into three concentrations namely marketing, human resources (HR) and finance (Finance). In the third-semester students are required to choose one concentration of the field of economics according to their competence. But the obstacle is often found in the choice of concentration in the field of economics is that many students still unable recognize their interests and abilities. Besides, many students who choose the concentration in the field of economics only follow the most specialization, but do not follow based on their abilities. According to that, it requires the tool to able to provide decision support in term of selecting concentrations based on predetermined considerations. The methods used in solving this problem are Weighted Average Method and Tsukomoto Fuzzy FIS Method with 4 (four) input variables and 3 (three) output variables. Input variables consist of subject values, interest values, motivation values , and abilities. While the output variable consists of marketing concentration, human resources (HR) and finance (Finance) The sample was taken from second semester students of Master of Management.The test results show that the recommendation for the selection of the right concentration for these students is Financial specialization with a Defuzzification value of 65.91 higher than Marketing and Human Resources specialization which is 64,69 and 64,59, respectively Keywords: Decision Support System, Weighted Average Method, Tsukomoto Fuzzy FIS Method, Concentration
SISTEM PAKAR FORWARD CHAINING , FUZZY-MAX DAN CERTAINTY FACTOR AYAM PEDAGING
Authors: Afandi Asep , Efendi Dwi Marisa 
Published: November 2021

Chicken farming is one of the promising business potentials, but in management and care, it is very important to determine the success of chicken farming. Often in the care of negligent employees so that they are exposed to disease outbreaks. With various types of diseases that attack the symptoms are very similar and even the same as other diseases, therefore an expert system can be used to diagnose a disease by looking at the characteristics of the disease suffered, and how the solution is to treat or prevent the disease In the study, it discusses 8 types of broiler diseases, where the expert system method used is the Fuzzy Max method, Forward Chaining, and Certainty Factor. From the results of the Fuzzy Max method, the results showed an accuracy of 80% - 90% for all types of diseases, while the Certainty Factor method showed 96% - 99% for all types of diseases.Keywords— Expert System, Fuzzy Max, Certainty Factor, Forward Chaining.
SURGICAL TREATMENT OF ACUTE THROMBOSIS ARTERIES OF INFRAPOPLITEAL SEGMENT
Authors: Hupalo Y. , Nabolotnyi O. , Kulikovskyi B. , Shved O. , Shaprynskyi V. , Shamrai-Sas A. , Holiachenko O. , Makivchuk D. , Gurianov V. 
Published: November 2021

Aim of the study. Aim of the study was to analyze the outcomes of surgical treatment of acute thrombosis of the popliteal-tibial segment arteries with various etiological factors of its occurrence.
The analysis of the surgical treatment of 40 patients with acute thrombosis of the popliteal-tibial segment arteries was carried out for the period from 2014 to 2020. Depending on the pathogenesis of acute thrombosis of the popliteal-tibial segment arteries, the patients were divided into three groups: Group 1 – 17 (42.5%) patients with acute arterial thrombosis of the popliteal-tibial segment caused by embolism or thrombosis in the background of stenotic-occlusive diseases of the lower extremitiesvessels; Group 2 – 15 (37.5%) patients with acute arterial thrombosis of the popliteal-tibial segment in the background of thromboangiitisobliterans of the lower extremities (Buerger's disease); Group 3 – 8 (20%) patients with acute arterial thrombosis of the popliteal-tibial segment in the background of popliteal artery aneurysm. During the follow-up period of 2 months, the incidence of rethrombosis and amputation of the lower limb in the patients of Group A was 5.9% and 5.9%, respectively. In Group B, the incidence of rethrombosis and amputation of the lower limb was 73.3% and 40.0%, respectively. In group C, the incidence of rethrombosis and amputation of the lower limb was 12.5% and 12.5%, respectively.
Conclusions. In patients with acute arterial thrombosis of the popliteal-tibial segment in the background of embolism or stenotic-occlusive diseases, combined endovascular or hybrid surgical interventions showed better results compared to open thrombectomy, in which rethrombosis was diagnosed in 14.3% of cases. In patients with thromboangiitis obliterans of the lower extremities, regional catheter-directed thrombolysis showed better (p=0,04) results compared to open thrombectomy and endovascular interventions, in which rethrombosis was diagnosed in 90% and 100% of cases, respectively. In patients with popliteal artery aneurysm, open surgical interventions or regional catheter-directed thrombolysis showed better results compared to endovascular interventions, in which rethrombosis was diagnosed in 50% of cases.
Safety of pediatric cerebral angiography
Authors: Lauzier David C. , Osbun Joshua W. , Chatterjee Arindam R. , Moran Christopher J. , Kansagra Akash P. 
Published: November 2021

OBJECTIVE
Catheter-based cerebral angiography is commonly used for neurovascular diagnosis in children. In this work, the authors aimed to quantify the complication rate of cerebral angiography in children, characterize these complications, and identify risk factors for complications.

METHODS
Relevant clinical data were retrospectively obtained for 587 consecutive cerebral angiography procedures performed in 390 children from March 2002 to March 2020. Complications were categorized as neurological or nonneurological, and severity was graded using a standard schema. Incidences of complications were reported as point estimates. Associations between risk factors and complications were characterized in univariate analysis using the two-tailed Fisher exact test and in multivariate analysis using multiple logistic regression with bidirectional elimination based on the Akaike information criterion. In both univariate and multivariate analyses, statistical significance was corrected for multiple comparisons using the Benjamini-Hochberg method.

RESULTS
Complications occurred in 6.5% of procedures, including neurological complications in 1.9% and nonneurological complications in 4.8%. Permanent deficits occurred in only 0.2% of cases. Overall, 0.5% of procedures resulted in major complications, while 6.0% resulted in minor complications. Female sex and a history of hypertension or ischemic stroke were associated with an increased risk of complications, while femoral artery access was associated with a decreased risk of complications.

CONCLUSIONS
Pediatric cerebral angiography was shown to have a low rate of major or permanent complications. Children who were female and those with a history of hypertension or ischemic stroke were shown to be at higher risk of complications, while the use of femoral access carried a lower risk of complications.
Learning Al-Islam and Kemuhammadiyahan by Using Blended Learning in the New Normal at MTs Muhammadiyah Lubuk Jambi
Authors: Tarsupon Tarsupon 
Published: November 2021

The implementation of learning in the new normal is not much different from learning during the Covid-19 pandemic, therefore it takes teacher creativity for successful learning implementation. The creativity of Al-Islam and Kemuhammadiyahan teachers at MTs Muhammadiyah Lubuk Jambi is to use blended learning, therefore this research aims to reveal how the implementation of blended learning in AIK learning in the new normal. The study uses a qualitative approach, the data source consists of key informants and additional informants. Data collection techniques are observation, interviews and documentation studies. Data is analyzed using interactive techniques. The application of blended learning model in MTs Muhammadiyah Lubuk Jambi is done by combining online and offline. The obstacles faced by using blended learning are from the aspect of teachers, learners and facilities. Research recommendations require comprehensive training to realize teachers who have information technology capabilities.
Design, Model & Planning of Prosumer Microgrid for MNS UET Multan Campus
Authors: Javed Haseeb 
Published: November 2021

The goal of this study is to provide a model and conceptual design for a prosumer campus microgrid that will help the university campus economically. The proposed model is based on solar PV installation at department rooftop for the campus of Muhammad Nawaz Sharif University of Engineering and Technology's in Multan, Pakistan. This study indicates that a 3,196-kW grid-connected solar photovoltaic system may generate enough electrical power to meet consumption, reducing grid reliance and minimizing energy from grid supply. This study also includes an economical and financial analysis of the proposed system based on various assumptions. PVSol Software was used to conduct a solar potential study and design of the site. Our study and analysis revealed that our suggested PV model can create 3,196.53 kWh of PV energy (DC), which is about 81.6 percent of the yearly consumption of our chosen site of 3,784.56 kWh.
ANALISIS PENERAPAN GREEN HUMAN RESOURCE MANAGEMENT PADA PERUSAHAAN TEKSTIL
Authors: Purnomo Albert Kurniawan 
Published: November 2021

Companies that want to grow and progress rapidly need strategies and take care of their employees. Nowadays, the concept of an environmentally friendly company is able to provide benefits. The advantage that will be obtained is that the company is able to reduce costs because it is replaced by an online system, reduce emissions or waste, and the company can also seek to recycle waste into other finished goods. This study aims to analyze the application of the concept of go green company the textile industry in Bandung. The respondents studied were 22 supervisors/ managers. The data analysis technique used is descriptive analysis. The results obtained, the implementation of Green HRM has been carried out well.
Keywords: Descriptive, Green HRM, Waste, Go green.

Abstrak
Perusahaan yang ingin berkembang dan maju pesat perlu strategi dan menjaga para karyawan. Di masa sekarang konsep perusahaan ramah lingkungan mampu memberikan keuntungan. Keuntungan yang akan diperoleh adalah perusahaan mampu mengurangi biaya karena tergantikan oleh sistem online, mengurangi emisi atau sampah, dan perusahaan juga bisa mengupayakan untuk mendaur ulang limbah menjadi barang jadi lainnya. Penelitian ini bertujuan untuk menganalisis penerapan konsep perusahaan ramah lingkungan di industri tekstil di kota Bandung. Responden yang diteliti sebanyak 22 supervisor / manajer. Teknik analisis data yang dilakukan adalah analisis deksriptif. Hasil yang diperoleh, penerapan Green HRM sudah terlaksana dengan baik.
Kata kunci: Deskriptif, Green HRM, Limbah, Ramah Lingkungan