bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality indicators development and prioritisation for emergency medical call centres: a stakeholder consensus
Authors: Alem Lucie , Bacqué Julie , Guihenneuc Jérémy , Delelis-Fanien Henri , Mimoz Olivier , Migeot Virginie 
Published: May 2021

IntroductionEmergency medical regulation is a risky activity. In France, emergency medical societies have proposed activity and performance indicators, but their lists are non-exhaustive, unstructured and used heterogeneously among emergency medical call centres (Centres de Réception et de Régulation des Appels, CRRA). Our objective was to build by means of regional stakeholder consensus an operational quality dashboard for CRRAs.MethodsWe conducted an observational step in a French CRRA from June to September 2018 and at the same time listed existing activity and quality indicators through a rapid international literature review. We adapted and classified all indicators identified in a structured table. We prioritised them from April to September 2019 by seeking consensus with one regulator physician and one medical regulation assistant from the 13 CRRAs of the largest French region. We used an adapted Delphi method with a prioritisation scale from 1 to 9.ResultsThe rapid review of literature included 33 studies among the 414 identified and, with the first observational step, resulted in a list of 360 quality indicators covering the following areas: material resources, human resources, quality approach, call handling and postcall support. 15 of the 26 members participated in the entire process. Seventy indicators were considered as priorities with strong agreement among participants. We built an operational dashboard of quality indicators deemed high priority and provided 70 descriptive indicator sheets.ConclusionOur study allowed to build an operational quality dashboard for CRRAs as a ready-to-use support for an internal audit, for prioritisation of quality approach actions and for national and international benchmarking.
Building the barricade—DIY slit lamp breath shield
Authors: Wu Clara Hoi Ka , Jarrar Zakariya , Harsum Steven 
Published: May 2021

Ophthalmologists were concerned about the risk of SARS-COV-2 transmission via droplets given the close proximity to the patient during slit lamp examination. There is a need to design a simple, low-cost, waterproof breath shield to minimise risk of infection.Dimensions of the Haag-Streit slit lamp (model BM 900) were recorded to guide accurate design of the breath shield. A questionnaire was circulated among slit lamp users on their perceived risk and concern about SARS-CoV-2 transmission and their perception of how effective different designs of breath shields would be at protecting them from an infection. A number of breath shield prototypes were designed and trialled. Plan, Do, Study, Act (PDSA) cycles were used to improve the design. Materials used to create the breath shields included transparent A3 laminating pouches and laminator, two sheets of A4 paper, scissors, hole punch and a ruler. The breath shield was designed to fit over the objective lens on the slit lamp after temporarily removing the standard, manufacturer-provided breath shield, before replacing it. The breath shields were cleaned after every patient with alcohol wipes and removed for deep cleaning with hand soap and water after each session. We used a proof of concept experiment using fluorescein instilled spray to test the effectiveness of each breath shield at preventing droplet transmission to the slit lamp user.Following four PDSA cycles, a breath shield that is user-friendly, easy to clean was produced. The percentage of confidence that the final design would be effective at preventing droplet transmission increased from 5.6% to 80%.Implementation of a low cost, simple to make, transparent, waterproof breath shield together with other forms of person protective equipment (PPE) creates a safe working environment for clinicians and patients. This intervention can be readily replicated and modified for other slit lamp models.
Impact of lockdown and school closure on children’s health and well-being during the first wave of COVID-19: a narrative review
Authors: Rajmil Luis , Hjern Anders , Boran Perran , Gunnlaugsson Geir , Kraus de Camargo Olaf , Raman Shanti 
Published: May 2021

BackgroundIn the context of containment measures against the COVID-19 pandemic, the aims were to examine the impact of lockdown and school closures on childs’ and adolescents’ health and well-being and social inequalities in health.MethodsLiterature review by searching five databases until November 2020. We included quantitative peer-reviewed studies reporting health and well-being outcomes in children (0–18 years) related to closure measures" impact due to COVID-19. A pair of authors assessed the risk of bias of included studies. A descriptive and narrative synthesis was carried out.FindingsTwenty-two studies, including high-income, middle-income and low-income countries, fulfilled our search criteria and were judged not to have an increased risk of bias. Studies from Australia, Spain and China showed an increase in depressive symptoms and decrease in life satisfaction. A decrease in physical activity and increase in unhealthy food consumption were shown in studies from two countries. There was a decrease in the number of visits to the emergency department in four countries, an increase in child mortality in Cameroon and a decrease by over 50% of immunisations administered in Pakistan. A significant drop of 39% in child protection medical examination referrals during 2020 compared with the previous years was found in the UK, a decrease in allegations of child abuse and neglect by almost one-third due to school closures in Florida, and an increase in the number of children with physical child abuse trauma was found in one centre in the USA.InterpretationFrom available reports, pandemic school closure and lockdown have adverse effects on child health and well-being in the short and probably long term. We urge governments to take the negative public health consequences into account before adopting restrictive measures in childhood.
Higgs-mass predictions in the MSSM and beyond
Authors: Slavich P. , Heinemeyer S. , Bagnaschi E. , Bahl H. , Goodsell M. , Haber H. E. , Hahn T. , Harlander R. , Hollik W. , Lee G. , Mühlleitner M. , Paßehr S. , Rzehak H. , Stöckinger D. , Voigt A. , Wagner C. E. M. , Weiglein G. , Allanach B. C. , Biekötter T. , Borowka S. , Braathen J. , Carena M. , Dao T. N. , Degrassi G. , Domingo F. , Drechsel P. , Ellwanger U. , Gabelmann M. , Gröber R. , Klappert J. , Kwasnitza T. , Meuser D. , Mihaila L. , Murphy N. , Nickel K. , Porod W. , Rojas E. A. Reyes , Sobolev I. , Staub F. 
Published: May 2021

AbstractPredictions for the Higgs masses are a distinctive feature of supersymmetric extensions of the Standard Model, where they play a crucial role in constraining the parameter space. The discovery of a Higgs boson and the remarkably precise measurement of its mass at the LHC have spurred new efforts aimed at improving the accuracy of the theoretical predictions for the Higgs masses in supersymmetric models. The “Precision SUSY Higgs Mass Calculation Initiative” (KUTS) was launched in 2014 to provide a forum for discussions between the different groups involved in these efforts. This report aims to present a comprehensive overview of the current status of Higgs-mass calculations in supersymmetric models, to document the many advances that were achieved in recent years and were discussed during the KUTS meetings, and to outline the prospects for future improvements in these calculations.
Quark, pion and axial condensates in three-flavor finite isospin chiral perturbation theory
Authors: Adhikari Prabal , Andersen Jens O. , Mojahed Martin A. 
Published: May 2021

AbstractWe calculate the light-quark condensate, the strange-quark condensate, the pion condensate, and the axial condensate in three-flavor chiral perturbation theory ($$\chi $$χPT) in the presence of an isospin chemical potential at next-to-leading order at zero temperature. It is shown that the three-flavor$$\chi $$χPT effective potential and condensates can be mapped onto two-flavor$$\chi $$χPT ones by integrating out mesons with strange-quark content (kaons and eta), with renormalized couplings. We compare the results for the light-quark and pion condensates at finite pseudoscalar source with ($$2+1$$2+1)-flavor lattice QCD, and we also compare the axial condensate at zero pseudoscalar and axial sources with lattice QCD data. We find that the light-quark, pion, and axial condensates are in very good agreement with lattice data. There is an overall improvement by including NLO effects.
Fork and Join Queueing Networks with Heavy Tails: Scaling Dimension and Throughput Limit
Authors: Zeng Yun , Tan Jian , Xia Cathy H. 
Published: May 2021

Parallel and distributed computing systems are foundational to the success of cloud computing and big data analytics. These systems process computational workflows in a way that can be mathematically modeled by a fork-and-join queueing network with blocking (FJQN/B). While engineering solutions have long been made to build and scale such systems, it is challenging to rigorously characterize their throughput performance at scale theoretically. What further complicates the study is the presence of heavy-tailed delays that have been widely documented therein. In this article, we utilize an infinite sequence of FJQN/Bs to study the throughput limit and focus on an important class of heavy-tailed service times that are regularly varying with index

. The throughput is said to be scalable if the throughput limit infimum of the sequence is strictly positive as the network size grows to infinity. We introduce two novel geometric concepts—scaling dimension and extended metric dimension—and show that an infinite sequence of FJQN/Bs is throughput scalable if the extended metric dimension

and only if the scaling dimension

. We also show that for the cases where buffer sizes are scaling in an order of

, the scalability conditions are relaxed by a factor of

. The results provide new insights on the scalability of a rich class of FJQN/Bs with various structures, including tandem, lattice, hexagon, pyramid, tree, and fractals.
CoSam: An Efficient Collaborative Adaptive Sampler for Recommendation
Authors: Chen Jiawei , Jiang Chengquan , Wang Can , Zhou Sheng , Feng Yan , Chen Chun , Ester Martin , He Xiangnan 
Published: May 2021

Sampling strategies have been widely applied in many recommendation systems to accelerate model learning from implicit feedback data. A typical strategy is to draw negative instances with uniform distribution, which, however, will severely affect a model’s convergence, stability, and even recommendation accuracy. A promising solution for this problem is to over-sample the “difficult” (a.k.a. informative) instances that contribute more on training. But this will increase the risk of biasing the model and leading to non-optimal results. Moreover, existing samplers are either heuristic, which require domain knowledge and often fail to capture real “difficult” instances, or rely on a sampler model that suffers from low efficiency.
To deal with these problems, we propose CoSam, an efficient and effective collaborative sampling method that consists of (1) a collaborative sampler model that explicitly leverages user-item interaction information in sampling probability and exhibits good properties of normalization, adaption, interaction information awareness, and sampling efficiency, and (2) an integrated sampler-recommender framework, leveraging the sampler model in prediction to offset the bias caused by uneven sampling. Correspondingly, we derive a fast reinforced training algorithm of our framework to boost the sampler performance and sampler-recommender collaboration. Extensive experiments on four real-world datasets demonstrate the superiority of the proposed collaborative sampler model and integrated sampler-recommender framework.
In Situ Stress Distribution and Its Control on the Coalbed Methane Reservoir Permeability in Liulin Area, Eastern Ordos Basin, China
Authors: Feng Peng , Li Song , Tang Dazhen , Wu Liangjun , Zhang Yan , Zhong Guanghao 
Published: May 2021

Permeability is one of the important factors that affect the production efficiency of coalbed methane, and it is mainly controlled by in situ stress. Therefore, it is very essential to study the in situ stress and permeability for the extraction of coalbed methane. Based on the injection/falloff well test and in situ stress measurement of 35 coalbed methane wells in the Liulin area in the east of the Ordos basin, the correlations between initial reservoir pressure, in situ stress, lateral stress coefficient, permeability, and burial depth were determined. Finally, the distribution characteristics of in situ stress and its influence on permeability were analyzed systematically. The results show that with the increase of burial depth, the initial reservoir pressure and in situ stress both increase, while the lateral stress coefficient decreases. The permeability variation is related to the type of stress field in different burial depths, and its essence is the deformation and destruction of coal pore structures caused by stress. The distribution characteristics of in situ stress at different depths and its effect on permeability are as follows: at

depths
<
800

m

, the horizontal principal stress is dominant (

σ

H

≥

σ

v

>

σ

h

) and the permeability is a simple decreasing process with the increase of the depth; at

depths
>
800

m

, the vertical stress is dominant (

σ

v

≥

σ

H

>

σ

h

). The permeability of most coal is very small due to the large in situ stresses in this depth zone. However, because of the stress release at the syncline axis, coal with high permeability is still possible at this depth zone. Due to the existence of high permeability data points at burial depth (>800 m) and the fitting relationship between permeability and vertical stress, the maximum and minimum horizontal principal stress is poor. However, the coal permeability and lateral stress coefficient show a good negative exponential relationship. This indicates that the lateral stress coefficient can be used to predict permeability better.
Intravital Imaging Identifies the VEGF–TXA2 Axis as a Critical Promoter of PGE2 Secretion from Tumor Cells and Immune Evasion
Authors: Konishi Yoshinobu , Ichise Hiroshi , Watabe Tetsuya , Oki Choji , Tsukiji Shinya , Hamazaki Yoko , Murakawa Yasuhiro , Takaori-Kondo Akifumi , Terai Kenta , Matsuda Michiyuki 
Published: May 2021

Abstract

Prostaglandin E2 (PGE2) promotes tumor progression through evasion of antitumor immunity. In stark contrast to cyclooxygenase-dependent production of PGE2, little is known whether PGE2 secretion is regulated within tumor tissues. Here, we show that VEGF-dependent release of thromboxane A2 (TXA2) triggers Ca2+ transients in tumor cells, culminating in PGE2 secretion and subsequent immune evasion in the early stages of tumorigenesis. Ca2+ transients caused cPLA2 activation and triggered the arachidonic acid cascade. Ca2+ transients were monitored as the surrogate marker of PGE2 secretion. Intravital imaging of BrafV600E mouse melanoma cells revealed that the proportion of cells exhibiting Ca2+ transients is markedly higher in vivo than in vitro. The TXA2 receptor was indispensable for the Ca2+ transients in vivo, high intratumoral PGE2 concentration, and evasion of antitumor immunity. Notably, treatment with a VEGF receptor antagonist and an anti-VEGF antibody rapidly suppressed Ca2+ transients and reduced TXA2 and PGE2 concentrations in tumor tissues. These results identify the VEGF–TXA2 axis as a critical promoter of PGE2-dependent tumor immune evasion, providing a molecular basis underlying the immunomodulatory effect of anti-VEGF therapies.

Significance:
This study identifies the VEGF–TXA2 axis as a potentially targetable regulator of PGE2 secretion, which provides novel strategies for prevention and treatment of multiple types of malignancies.
Ripretinib and MEK Inhibitors Synergize to Induce Apoptosis in Preclinical Models of GIST and Systemic Mastocytosis
Authors: Gupta Anu , Singh Jarnail , García-Valverde Alfonso , Serrano César , Flynn Daniel L. , Smith Bryan D. 
Published: May 2021

AbstractThe majority of gastrointestinal stromal tumors (GIST) harbor constitutively activating mutations in KIT tyrosine kinase. Imatinib, sunitinib, and regorafenib are available as first-, second-, and third-line targeted therapies, respectively, for metastatic or unresectable KIT-driven GIST. Treatment of patients with GIST with KIT kinase inhibitors generally leads to a partial response or stable disease but most patients eventually progress by developing secondary resistance mutations in KIT. Tumor heterogeneity for secondary resistant KIT mutations within the same patient adds further complexity to GIST treatment. Several other mechanisms converge and reactivate the MAPK pathway upon KIT/PDGFRA–targeted inhibition, generating treatment adaptation and impairing cytotoxicity. To address the multiple potential pathways of drug resistance in GIST, the KIT/PDGFRA inhibitor ripretinib was combined with MEK inhibitors in cell lines and mouse models. Ripretinib potently inhibits a broad spectrum of primary and drug-resistant KIT/PDGFRA mutants and is approved by the FDA for the treatment of adult patients with advanced GIST who have received previous treatment with 3 or more kinase inhibitors, including imatinib. Here we show that ripretinib treatment in combination with MEK inhibitors is effective at inducing and enhancing the apoptotic response and preventing growth of resistant colonies in both imatinib-sensitive and -resistant GIST cell lines, even after long-term removal of drugs. The effect was also observed in systemic mastocytosis (SM) cells, wherein the primary drug–resistant KIT D816V is the driver mutation. Our results show that the combination of KIT and MEK inhibition has the potential to induce cytocidal responses in GIST and SM cells.
Uma abordagem atual da utilização de antidepressivos no manejo da depressão pós-parto
Authors: Da-Silva Thiago Guimarães , Vasconcelos Pedro Fonseca de , Moura Ivan Gilson Silva 
Published: May 2021

Objetivo: caracterizar a utilização de antidepressivos no manejo da depressão pós-parto. Método: empregou-se uma revisão integrativa de literatura, das bases de dados PubMed e Biblioteca Virtual em Saúde, com aplicação de descritores, visando responder a pergunta norteadora do trabalho, entre os dias 25 de fevereiro e 10 de março de 2019. Com base nos critérios de inclusão e exclusão, foram selecionados 23 artigos que, posteriormente, foram submetidos à categorização. Resultados: a sertralina deve ser a droga de escolha para o tratamento farmacológico da depressão puerperal. Constatou-se também, que a utilização profilática de antidepressivos em mulheres susceptíveis é contestável e pouco se sabe sobre os possíveis efeitos colaterais. Ademais, foi encontrado que não há consenso sobre a superioridade da terapia farmacológica em detrimento às psicoterapias. Conclusão: há evidencias que fundamentam o uso de sertralina, paroxetina, duloxetina, nortriptilina e imipramina para tratar mulheres com depressão pós-parto, sendo a amamentação sempre recomendada. Ressalta-se que emerge a necessidade de estudos com amostras representativas para validar ou restringir o uso de psicofármacos na profilaxia da depressão puerperal.
De 德 in the Zuozhuan《左傳》
Authors: Pines Yuri 
Published: May 2021

Abstract
This article surveys the usages of the term de 德 in the Zuozhuan《左傳》. It demonstrates the term’s hermeneutical richness: de could refer to charismatic power, to political potency, to proper decorum, to mildness and kindness in domestic or interstate affairs, to individual morality, and so forth. Behind this richness, though, we may discern a clear predominance of political usages of de and paucity of references to de as personal moral virtue. Notably, Zuozhuan never refers to de in the context of moral self-cultivation. The article discusses the reasons for this peculiarity.
Forecast of low clouds over a snow surface in the Arctic using WRF model
Authors: Hagman M. , Svensson G. , Angevine W.M. 
Published: May 2021

AbstractThe Swedish Armed Forces configuration of the Weather Research and Forecasting Model (WRF) has problems in forecasting low clouds in stably stratified conditions when the ground is covered by snow. Reforecasts for January and February 2018, together with observations from Sodankylä in northern Finland, are analyzed to find the cause. The investigation is done iteratively between the Single Column Model (SCM), applied at Sodankylä, and the full 3D version. Our experiments show that the forecast error arises due to inadequate initialization of Stratocumulus (Sc) clouds in WRF using the ECMWF global model, Integrated Forecast System (IFS). By including bulk liquid water and bulk ice water content, from IFS in the initial profile, the downwelling long wave radiation increases and prevents the near surface temperature from dropping abnormally. This, in turn, prevents artificial clouds from forming at the first model level. When no clouds are present in the IFS initial profile, the Sc clouds can be initialized using information from the observed vertical profiles. Generally, initialization of Sc clouds in WRF improves the forecast substantially.
Airway Management in Substernal Goiter Surgery
Authors: Tasche Kendall K. , Dorneden Ashley M. , Swift William M. , Boyd Nathan H. , Shonka David C. , Pagedar Nitin A. 
Published: May 2021

Objective(s): To review the experience of 3 hospitals with airway management during surgery for substernal goiter and identify preoperative factors that predict the need for advanced airway management techniques. Methods: A retrospective chart review between 2009 and 2017 of patients with substernal goiter treated surgically at 1 of 3 hospitals was performed. Results: Of the 179 patients included in the study, 114 (63.7%) were female, the mean age was 55.1 years (range 20-87). Direct laryngoscopy or videolaryngoscopy was successful in 162 patients (90.5%), with fiberoptic intubation used for the remaining 17 patients. Thirty-one patients (17.4%) required >1 intubation attempt; these patients had larger thyroids (201.3 g, 95% CI 155.3-247.2 g) than those intubated with 1 attempt (144.7 g, 95% CI 127.4-161.9 g, P = .009). Those who required >1 attempt had higher BMI (38.3, 95% CI 34.0-42.6 vs. 32.9, 95% CI 31.5-34.3, P = .02). Mallampati score was found to be a predictor of >1 attempt, though tracheal compression and tracheal shift were not found to be predictors of >1 attempt, nor was the lowest thyroid extent. BMI was the only independent factor on multivariable logistic regression of needing >1 attempt (odds ratio 1.056, 95% CI 1.011-1.103, P  = .015). Conclusions: The majority of patients undergoing surgery for substernal goiter can be intubated routinely without the need for fiberoptic intubation. Thyroid-specific factors such as lowest thyroid extent and mass effect of the gland on the trachea do not appear to be associated with difficult intubation, whereas classic patient factors associated with difficulty intubation are. Level of evidence: VI