bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytoreductive Stereotactic Body Radiotherapy with Tyrosine Kinase Inhibitors for Intrathoracic Oligoprogressive EGFR-mutated Lung Cancer
Authors: Rishi Anupam , Sun Steven , Karimi Ahmad M , Sim Austin J , Shafique Michael , Saltos Andreas N , Gray Jhanelle E , Perez Bradford A , Dilling Thomas J , Rosenberg Stephen A 
Published: December 2021

Abstract
Background: Epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC) shows an impressive initial response to EGFR tyrosine kinase inhibitors (EGFR-TKI). However, resistance invariably develops, commonly involving the site of initial gross disease. Cytoreductive stereotactic body radiotherapy (SBRT) for thoracic oligoprogressive disease (OPD) may effectively delay progression through EGFR-TKI therapy.Methods: From a prospectively maintained IRB-approved institutional registry, we identified 23 patients consecutively treated between 2011-2019 with thoracic SBRT and received EGFR-TKI within 6-months of SBRT. Radiographic progression-free (PFS) and overall survival (OS) were estimated using Kaplan-Meier analysis. Toxicity and patient-reported Edmonton Symptom Assessment Scale (ESAS) scores were reviewed.Results: Median follow-up after SBRT was 20-months (range, 4-100), and the median age was 68-years (range, 33-89). Most patients were females (n=21;91.3%). RT dose was 50-60 Gy in 5-10 fractions. EGFR-TKI administered were erlotinib, osimertinib and gefitinib in 15, 5, and 3 patients, respectively. Median PFS and OS following SBRT were 8-months and 31-months, respectively. 1-year PFS and OS were 34.8% and 78.3%. The median duration of EGFR-TKI therapy was 26-months (1-91). Most patients progressed in new distant sites, most commonly bones (n=5;21.7%) and distant lung (n=4;17.4%), with only 2/23 patients having initial progression within the SBRT field. Grade-2 pneumonitis (n=2) and rib fracture (n=1) were noted radiation-related toxicities. Dominant ESAS symptoms were fatigue (21.7%), pain (8.7%), and loss of appetite (8.7%).Conclusions: For EGFR-mutated NSCLC patients with thoracic OPD on EGFR-TKI, SBRT was well tolerated, resulted in changes in subsequent patterns of failure, lengthened PFS, and prolongs the duration of initial TKI therapy.
MRI-Based Radiomics Approach Predicts Tumor Recurrence in ER+/HER2- Early Breast Cancer Patients
Authors: Pizzi Andrea Delli , Mastrodicasa Domenico , Chiarelli Antonio Maria , Chiacchiaretta Piero , Luberti Riccardo , Croce Pierpaolo , Sguera Mario , Torrione Concetta , Marinelli Camilla , Marchetti Chiara , Domenico Angelucci , Cocco Giulio , Credico Angela Di , Russo Alessandro , D'Eramo Claudia , Sensi Stefano , Muzi Marzia , Caulo Massimo 
Published: December 2021

Abstract
Oncotype Dx is a genetic assay providing a recurrence score (RS) correlated with the risk of cancer recurrence and adjuvant treatment response in breast carcinoma. We investigated the ability of an MRI-based radiomics approach to predict the risk of tumor recurrence in breast cancer. A total of 62 patients with biopsy-proved ER+/HER2- early breast cancer who underwent pre-treatment MRI and Oncotype Dx were included. An RS>25 was considered discriminant between low-intermediate and high risk of tumor recurrence. Two readers segmented each tumor. Radiomics features were extracted from the tumor and the peritumoral tissues. Partial least square (PLS) regression was used as the multivariate machine-learning algorithm. PLS β-weights of radiomics features included the 5% features with the largest β-weights in magnitude (top 5%). The diagnostic performance of the radiomics model was assessed through receiver operating characteristic (ROC) analysis. A null hypothesis probability threshold of 5% was chosen (p < 0.05). The predictive model delivered an AUC of 0.76. Of the 47 features included in the top 5%, 33 were texture-related and derived from the tumor and the peritumoral tissues. After a prospective evaluation in more extensive clinical trials, this approach may identify non-invasively patients who are more likely to benefit from adjuvant therapy.
Understanding the Implementation of Hierarchical Medical System Policy: An Interrupted Time Series Analysis of a Pilot Scheme in China
Authors: Hu Huajie , Wang Ruilin , Li Huangqianyu , Han Sheng , Shen Peng , Lin Hongbo , Guan Xiaodong , Shi Luwen 
Published: December 2021

Abstract
Background The Chinese healthcare system faces a dilemma between its hospital-centric approach to healthcare delivery and a rapidly aging population that requires strong primary care. To improve system efficiency and continuity of care, the Hierarchical Medical System (HMS) policy package was implemented in 2015 in Zhejiang province, China. This paper investigated the impact of HMS on the local healthcare system.MethodsWe conducted a repeated cross-sectional study with quarterly data collected between 2010 and 2018 from Yinzhou district, Ningbo. The data was analyzed with an interrupted time series (ITS) design to assess the impact of HMS on the changes of three outcome variables: primary care physicians (PCPs) patient encounter ratio (i.e., the mean quarterly number of patient encounters of PCPs divided by that of all other physicians), PCP degree ratio (i.e., the mean degree of PCPs divided by that of all other physicians), PCP betweenness centrality ratio (i.e., the mean betweenness centrality of PCPs divided by that of all other physicians). Results272,267 patients visited doctors for hypertension between 2010 and 2018. Compared to the counterfactual in the fourth quarter of 2018, the PCP patient encounter ratio rose by 42.7% (95%CI: 27.1—58.2, p<0.001), the PCP degree ratio increased by 23.6% (95%CI: 8.6—38.5, p<0.01), and the PCP betweenness centrality ratio grew by 129.4% (95%CI: 87.1—171.7, p<0.001).ConclusionsThe HMS policy can incentivize patients to visit primary care facilities and enhance the centrality of PCPs within their professional network. Local policymakers should sustain HMS policy efforts to obtain long-term and large-scale benefits.
Current Ecological Status of Remote Coral Reefs of Clipperton Island, Tropical Eastern Pacific
Authors: Pogoreutz Claudia , Clua Eric E. G. , LANGARICA JOSE DE JESUS ADOLFO TORTOLERO 
Published: December 2021

Abstract
Clipperton, an uninhabited and remote coral atoll from the Eastern Pacific, is an important steppingstone area that harbors a high marine biodiversity. Despite its biogeographic importance, little information on the ecological status of its coral reefs is available from the last decade. Herein, we characterized the benthic coral community and health status among four different shallow reef-zones (North to South) of Clipperton during the Tara Pacific expedition in 2018. The benthic composition and coverage percentage, as well as occurrence of a pink-spotted coral phenotype (trematodiasis infection) was assessed. Total live coral cover on Clipperton reefs was 66% (55-85%), differing between sites, with massive Porites and branching Pocillopora corals dominating the benthic community with an average 48% (32-66%), and 15% (3-21%), respectively. While Clipperton reefs exhibited significant live coral cover overall, the trematode infection was commonly observed, with a higher occurrence in massive corals (Porites 27%, and Pavona 31%). This observation is possibly related to the combined effects of previously heatwaves, and local inputs of guano-derived nutrients discharged during storms and hurricanes. These results demonstrates that even highly remote reefs supporting high coral cover can be subjected to local and global threats, including but not limited to parasite prevalence, likely in relation to natural disturbances such as thermal stress and tropical cyclones.
Sandblasting Defect Inspection of Investment Castings Based on Deep Convolutional Neural Network
Authors: Kuo Jenn-Kun , Wu Jun-Jia , Huang Pei-Hsing , Cheng Chin-Yi 
Published: December 2021

Abstract
Investment castings often have surface impurities and pieces of shell molds can remain on the surface after sandblasting. Identification of defects involves time-consuming manual inspections in working environments of high noise and poor air quality. To reduce labor costs and increase the health and safety of employees, we applied automated optical inspection (AOI) combined with a deep learning framework based on convolutional neural networks (CNNs) to the detection of sandblasting defects. We applied the following four classic CNN models for training and predictive classification: AlexNet, VGG-16, GoogLeNet, and ResNet-34. In terms of predictive classification, AlexNet, VGG-16, and GoogLeNet v1 could accurately determine whether there were defects. Among the four models, AlexNet was the most accurate, with prediction accuracy of 99.53% for qualifying products and 100% for defective products. We demonstrate a direct detection technique based on the AOI and CNN structure with a fast and flexible computational interface.
Exploring myocardial fibrosis in severe aortic stenosis: echo, CMR and histology data from FIB-AS study
Authors: Balčiūnaitė Giedrė , Besusparis Justinas , Palionis Darius , Žurauskas Edvardas , Skorniakov Viktor , Janušauskas Vilius , Zorinas Aleksejus , Zaremba Tomas , Valevičienė Nomeda , Šerpytis Pranas , Aidietis Audrius , Ručinskas Kęstutis , Sogaard Peter , Glaveckaitė Sigita 
Published: December 2021

Abstract
PurposeMyocardial fibrosis in aortic stenosis (AS) is associated with worse survival following aortic valve replacement (AVR). We assessed myocardial fibrosis in severe AS patients, integrating echocardiographic, cardiovascular magnetic resonance (CMR) and histological data. MethodsA total of 83 severe AS patients (age 66.4 ± 8.3, 42% male) who were scheduled for surgical AVR underwent CMR with late gadolinium enhancement (LGE) and T1 mapping and global longitudinal strain (GLS) analysis. Collagen volume fraction (CVF) was measured in myocardial biopsies (71) that were sampled at the time of AVR. ResultsCVF correlated with imaging and serum biomarkers of LV systolic dysfunction and left side chamber enlargement and was higher in the sub-endocardium compared with midmyocardium (p<0.001). CVF median values were higher in LGE-positive versus LGE-negative patients [28.7% (19-33) vs 20.7% (15-30), respectively, p=0.040]. GLS was associated with invasively (CVF; r=-0.303, p=0.013) and non-invasively (native T1; r=-0.321, p<0.05) measured myocardial fibrosis. GLS and native T1 correlated with parameters of adverse LV remodelling, systolic and diastolic dysfunction and serum biomarkers of heart failure and myocardial injury. ConclusionOur data highlight the role of myocardial fibrosis in adverse cardiac remodelling in AS. GLS has potential as a surrogate marker of myocardial fibrosis, and high native T1 and low GLS values differentiated patients with more advanced cardiac remodelling.
A Wearable Low-cost Muscle Activated Switch for Wireless Control for the Physically Challenged Patients
Authors: Iqbal A. 
Published: December 2021

Abstract
BackgroundTo control the environmental conditions of the living place and to use the electrical appliances and computers etc. are one of the major challenges for the physically disabled persons and elderly people. The surface electro myography (sEMG) is employed to detect the muscle movement and used for games therapy and various others applications. This paper presents a low-cost wearable muscle switch designed to acquire sEMG signal and process it to provides the control, gaming therapy and mode of communication to the physically disabled patients.ResultsThis paper proposes a wearable low-cost muscle activated switch to assist the physically challenged members of the society. The designed muscle activated switch consists of Myoware muscle sensors that is used for data acquisition and to detect the muscle activity from the target muscle using Electromyography (EMG) signals. The Arduino board provides the human-computer interface and control to the devices based on the muscle signal. The Bluesmirf bluetooth is used for the wireless connectivity to our designed system that assists the physically disabled persons to use the computer and to control the home appliances via commercially available Grid 3 software and wifi switches. The novelty of this muscle sensor switch is that it can be connected to any bluetooth compatible devices that can be controlled from any targeted muscle. The system was tested with Grid 3 software on laptop for environmental control and text to speech conversion.ConclusionsA low cost muscle sensor based Bluetooth switch system for the physically disabled patients has been presented in this paper. The designed switch can be connected to any Bluetooth enabled device as demonstrated in this paper. The physically disable persons can select any module from the Grid 3 software such as the environmental control (to control the environment via electrical appliances), text to speech converter (for Aphasia patients), gaming therapy etc. The designed system can also be utilized to use the Bluetooth enabled electric gadgets such as Mobile Phones, Ipad and android Tablets etc. in accessibility mode.
Performance of 2019 EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus in Children and Adults : A Retrospective Observational Study
Authors: Cheng Sang , Ding Huihua , Xue Haiyan , Xia Min , Tu Zhiqiang , Zhang Weiqi , Cao Lanfang 
Published: December 2021

Abstract
Background: The European League Against Rheumatism (EULAR) and American College of Rheumatology (ACR) recently developed a systemic lupus erythematosus (SLE) classification criteria (EULAR/ACR-2019) with high sensitivity and specificity. The aim of this study was to validate and compare the performance of the newly developed criteria to that of the ACR-1997 and the 2012 Systemic Lupus International Collaborating Clinics (SLICC-2012) criteria in juvenile-onset SLE (jSLE) and adult-onset SLE (aSLE) patients.Methods: We conducted a retrospective study of SLE patients (221 children and adult) and controls (214 children and adult) with defined rheumatic diseases to establish the ACR-1997, SLICC-2012 and EULAR/ACR-2019 criteria. The performance of the three criteria was statistically analyzed.Results: For jSLE, sensitivities of ACR-1997, SLICC-2012 and EULAR/ACR-2019 criteria were 63.3%, 94.6% and 98.2% (P < 0.001), with specificities 99.5%, 98.6% and 93.5% (P < 0.001), respectively. For aSLE, sensitivities of ACR-1997, SLICC-2012 and EULAR/ACR-2019 criteria were 72.9%, 96.8% and 99.1% (P < 0.001), with specificities 97.2%, 92.5% and 90.2% (P = 0.013), respectively. In ANA positive juvenile patients, a EULAR/ACR score ≥13 instead of a score ≥10 resulted in higher specificity (93.1% vs. 75.9%), despite slightly lower sensitivity (92.2% vs. 99.5%). In both jSLE and aSLE patients, the SLICC-2012 and EULAR/ACR-2019 criteria had increased sensitivity for major organ involvement than ACR-1997.Conclusion: The EULAR/ACR-2019 criteria showed similar sensitivity to jSLE and aSLE patients and was more sensitive than ACR-1997 and SLICC-2012 criteria, allowing earlier recognition of patients with single or major organ involvement. The adoption of a EULAR/ACR total score ≥13 in this study, instead of the initially proposed ≥10 score, was more appropriate to classify jSLE.
Living with FGM: Improving Knowledge and Skills of Health Care Providers in Iraqi Kurdistan
Authors: Mahmoudi Osman 
Published: December 2021

Abstract
Background: Despite the high prevalence of female genital mutilation in many settings and the health consequences associated with it, many healthcare providers have limited knowledge of female genital mutilation and limited skills for preventing and managing related complications. With Knowledge of this Important matter aim of this study is to determine the effectiveness of TOT workshops on the knowledge and skills of social workers working with girls and women affected by FGM.Methods: To demonstrate the findings, a quasi-experimental study was conducted with a pre and post-assessment. There were 44 participants who worked with FGM victims across Iraqi Kurdistan. Socio-demographic details of the participants who have collected knowledge on psychosexual and physical care, psychosexual skills, and referral programs were assessed using a continuum scale of 0 to 4. Descriptive and inferential statistics were carried out for the analysis.Results: The results showed that participants' knowledge and skills improved in relation to psychosexual and physical care for girls and women living with FGM and referral programs for them. The paired sample t-test carried showed a significant increase in knowledge among participants in psychosexual and physical care for girls and women living with FGM (f=9.25, df=1, P=.001), Psychosexual skills (f=-8.20, df=1, P=.001), and FGM victims referral Programs (t=12.95, df=1, P=.001). Follow-up test also showed that these changes were constant from post-test to follow-up.Conclusions: Preparing the social workers on the integration of physical and psychosocial care for girls and women living with FGM in their existing activities would equip them in providing holistic care for them in addressing the emerging psychosexual problems.
Mesoporous ZnO@Co3O4 Nanosphere for Sensitive Detection of 3-Hydroxy-2-Butanone
Authors: Tian Xinxin , Yin Ming , Zhang Li , Qiu Tianyi , Xu Dongpo , Qiu Jingxuan 
Published: December 2021

Abstract
The mixed semiconductor metal oxides as the gas sensor can enhance the sensitivity compared with the metal oxide respectively. In this study, the mesoporous ZnO@Co3O4 nanosphere was prepared through the simple hydrothermal synthesis method of ZIF-L-Zn@Co, the cage construction of mesoporous ZnO@Co3O4 nanosphere was remained unchanged after the calcination of the ZIF-L-Zn@Co at 600℃ for 2 h in the air. The mesoporous ZnO@Co3O4 nanosphere was selected as the gas sensor for the detection of 3-Hydroxy-2-Butanone. Compared with the ZnO and Co3O4 respectively, the mesoporous ZnO@Co3O4 nanosphere as the gas sensor shows the high sensitivity, selectivity and stability.
Upregulated Ribosomal Pathway Impairs Follicle Development in a Polycystic Ovary Syndrome Mouse Model: Findings of Differential Gene Expression Analysis of Oocytes
Authors: Nakanishi Natsuki , Osuka Satoko , Kono Tomohiro , Kobayashi Hisato , Ikeda Shinya , Bayasula Bayasula , Seki Tomomi , Yabuki Atsushi , Tanaka Hideaki , Sonehara Reina , Murakami Mayuko , Yoshita Sayako , Miyake Natsuki , Muraoka Ayako , Kasahara Yukiyo , Murase Tomohiko , Nakamura Tomoko , Goto Maki , Iwase Akira , Kajiyama Hiroaki 
Published: December 2021

Abstract
Background: Polycystic ovary syndrome (PCOS), a common endocrinal disorder, is associated with impaired oocyte development, which leads to infertility. However, the pathogenesis of PCOS has not been completely elucidated. Limited studies have analyzed the pathological characteristics of oocytes in PCOS. This study aimed to analyze the differentially expressed genes (DEGs) and epigenetic changes in the oocytes of the PCOS mouse model to identify the etiological factors.Methods: C57BL/6J female mice were subcutaneously injected with vehicle or 5α-dihydrotestosterone (250 µg/day) on days 16–18 of pregnancy. Female offspring were used as the control or PCOS group. The oocytes were collected from mice aged 7–9 weeks. The DEGs between the control and PCOS groups were analyzed using RNA sequencing (RNA-Seq). Additionally, the DNA methylation status was analyzed using the post-bisulfite adaptor tagging method. The ovarian tissue sections were stained with hematoxylin and eosin to examine the morphological changes. The proteins, Rps21 and Rpl36, were measured using immunostaining.Results: Compared with the control group, the PCOS group exhibited impaired estrous cycle and polycystic ovary-like morphology. RNA-Seq analysis revealed that 90 DEGs were upregulated and 27 DEGs were downregulated in the PCOS mouse model. DNA methylation analysis revealed 30 hypomethylated and 10 hypermethylated regions in the PCOS group. However, the DNA methylation status was not correlated with differential gene expression. The Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed that five DEGs (Rps21, Rpl36, Rpl36a, Rpl37a, and Rpl22l1) were enriched in ribosome-related pathways. The immunohistochemical analysis revealed that the expression levels of Rps21 and Rpl36 were significantly upregulated in the PCOS mouse model.Conclusions: These results suggest that differential gene expression in the oocytes of the PCOS mouse model is related to impaired folliculogenesis. These findings improved our understanding of the pathogenesis of PCOS.
Gas Transport Characteristics of Mixed Matrix Membrane Containing MIL-100 (Fe) Metal-Organic Frameworks and PEBAX Precursors
Authors: Pirouzfar Vahid , Roustaie Narges , Salimi Mahmoud , Su Chia-Hung 
Published: December 2021

Abstract
In this research, the effect of adding MIL-100 (Fe) MOFs on the PEBAX membranes has been scrutinized in two grades of 1657 and 2533. Initially, the intended membranes were synthesized by the solution-casting method. Then, the XRD and SEM were applied to deliberate the influence of adding MIL-100 (Fe) to the structure of both types of membranes. In consequence, the separation function of the pair gases of CO2/CH4، CO2/N2 and CO2/O2 and their permeability were considered at the pressure of 3.5 bar and temperature of 25°C. Eventually, their function was compared by Robeson diagrams of 1991 and 2008. The comparison results by Robeson diagrams indicated that the PEBAX1657/MIL-100 (Fe) and PEBAX2533/MIL-100 (Fe) membranes containing 5 wt.% of MOF represent more suitable performance in separating CO2/CH4 in comparison with the axis of the Robeson diagram. However, their function for separating the aforementioned gases requires more modifications.
WITHDRAWN: Frontotemporal Dementia: A systematic review
Authors: Khalifa Samar 
Published: December 2021

Abstract
Background:
Frontotemporal dementia is a common type of dementia and is a group of progressive neurodegenerative syndromes usually caused by the accumulation of pathological tau or TDP-43 proteins. The review is identifying the clinical measures including neuropsychological scores and functional measures.
Methods:
A systematic review was conducted covering the clinical trials done to investigate the Frontotemporal Dementia. The sample was taken from Pubmed library. 28 results were found in a range of time from 2016 to 2021. The excluded papers were 17.
Results:
A total of 10,349 articles were identified at the first stage of papers selecting. All records were screened in order to include and exclude by title/abstract and then based on full text. After excluding articles by year and type of papers, a total of 28 articles were identified through the databases. Following this, the irrelevant papers from databases were removed from original articles, and finally 11 articles were included based on their title/abstract. Full articles were then sourced for about 600 references. It included 732 patients and 195 controls as a total.
Conclusions:
The review describes the clinical and RCT trials for FTD in the last five years so it can be very updated information for the researchers to cover information required for their researches in the future ones.