bluuebunny/crossref_metadata_2025_split huggingface dataset:
Darbo aplinkos veiksnių įtaka slaugytojų sveikatai
Authors: Aukštikalnytė Gintarė , Drungilienė Danguolė , Reigas Viljaras , Minelga Gintautas 
Published: August 2021

Tyrimo pagrindimas. Sveikatos priežiūros specialistų darbo aplinka yra svarbus veiksnys, kuris turi įtakos dirbančiųjų gyvenimo kokybei ir sveikatai. Darbe vyraujant tokiems psichosocialiniams rizikos veiksniams kaip, stresas, ilgos darbo valandos, dideli reikalavimai, susidūrimai su pacientų smurtu ir mirtimi, pamaininis darbas ir pan., sutrinka darbo ir poilsio režimas, darbuotojams sukeliamas stresas, pervargimas ir kt. Ne visi slaugytojai geba atlaikyti nuolat patiriamą darbo įtampą, todėl padidėja nepageidaujamų sveikatos problemų tikimybė.
Tikslas. Išanalizuoti darbo aplinkos veiksnių įtaką slaugytojų sveikatai.
Metodai. Anketinės apklausos būdu apklausti 121 slaugytojai, dirbantys ligoninėse. Apklausai atlikti naudoti darbo patirties vertinimo (WEMS) ir salutogeninių sveikatos indikatorių skalės (SHIS).
Rezultatai. Slaugytojų sveikata vertinta „Salutogeninių sveikatos indikatorių skale“. Bendrojo sveikatos rodiklio vidurkį bendroje tiriamųjų grupėje sudarė 60,96 balo, tarpasmeninių sveikatos indikatorių grupėse – 59,81 balo ir interaktyvių – 62,58 balo. Geriausiai vertintas bendravimas su kitais žmonėmis (4,38 balo), ryžtingumas (4,27 balo), emocinės pusiausvyros išlaikymas (4,20 balo), o blogiausiai miegas (3,74 balo), atsipalaidavimas (3,82 balo) ir energingumas (3,85 balo). Darbo patyrimo skalėje geriausiai vertintas prieinamumas prie vadovo, vadovo gebėjimas, prireikus priimti sprendimus, blogiausiai – vadovo konsultavimąsi su darbo grupe prieš priimant svarbius sprendimus. Darbo pokyčių srities teiginiai buvo vertinami blogiau nei kitų sričių, vyrai žymiai pozityviau vertino pokyčius įstaigoje nei moterys.
Išvados. Teigiama darbo patirtis buvo susijusi su geresniu savo sveikatos ir savijautos vertinimu. Bendrasis sveikatos rodiklis buvo blogesnis tarp tiriamųjų su didesniu darbo stažu, jie blogiau vertino tiek tarpasmeninius, tiek ir interaktyvius sveikatos indikatorius. Jaunesnio amžiaus slaugytojai palankiau vertino pokyčius įstaigoje, o vadovavimo sritį pozityviau vertino slaugytojai, turintys didesnį darbo stažą.
Raktažodžiai: slaugytojai, sveikatos indikatoriai, darbo veiksniai.
Pelatihan Desain dan Kemasan Produk Sebagai Upaya Meningkatkan Omset UMKM di Kota Batam
Authors: Arisandi Debby , Fitriansyah Ahmad 
Published: August 2021

The Micro, Small, and Medium Enterprises (MSMEs) sector contributed 60.34% to the gross domestic product (GDP) and assisted the absorption of labor by 97.22%. The problem is, there are still many MSMEs that are not aware or do not understand that good and attractive product packaging will bring added value to the products it offers. As a result, some products that actually have high selling value/quality do not sell in the market. This activity aims to increase the understanding of MSME players of the importance of packaging so that the products offered an increase in added value and can differentiate packaging based on function, type, and material. The implementation of community service activities was carried out on 18-19 July 2017 in the Gurindam Building Hall of the Batam City Education Office. The activity was carried out in collaboration with the Dinas Koperasi dan Usaha Mikro Kota Batam, which was attended by 128 MSMEs. The results of the activity were in the form of new packaging for participant products that were more attractive, informative, and modern.
Abstrak
Sektor Usaha Mikro, Kecil dan Menengah (UMKM) memberikan kontribusi terhadap produk domestik bruto (PDB) sebesar 60.34% dan membantu penyerapan tenaga kerja sebesar 97.22%. Permasalahannya, masih banyak UMKM tidak sadar atau kurang memahami bahwa kemasan produk yang baik dan menarik akan mendatangkan nilai lebih pada produk yang ditawarkannya. Akibatnya sejumlah produk yang sebenarnya memiliki nilai jual tinggi/bermutu menjadi tidak laku dipasaran. Kegiatan ini bertujuan untuk dapat meningkatkan pemahaman pelaku UMKM terhadap pentingnya kemasan agar produk yang ditawarkan meningkat nilai tambahnya dan dapat membedakan kemasan berdasarkan fungsi, jenis dan bahannya. Pelaksanaan kegiatan pengabdian kepada masyarakat dilaksanakan pada 18-19 Juli 2017 di Aula Gedung Gurindam kantor Dinas Pendidikan Kota Batam. Kegiatan dilaksanakan melalui kerjasama dengan Dinas Koperasi dan Usaha Mikro Kota Batam yang diikuti oleh 128 UMKM. Hasil kegiatan berupa kemasan baru bagi produk-produk peserta yang lebih menarik, informatif dan modern.
Kata Kunci: umkm; pelatihan; kemasan
Hydrodeoxygenation of Xylose Isopropylidene Ketal Over Pd/HBEA Catalyst for the Production of Green Fuels
Authors: Souza Matheus O. , Pereira Sergio C. , Lau Lam Y. , Soter Leandro , Pereira Marcelo M. 
Published: August 2021

1,2:3,5-Di-O-isopropylidene-α-D-xylofuranose (DX) is a major component of a new bio-crude: a viscous oil presenting petroleum-friendly properties produced by the ketalization of sugarcane bagasse. This article studies DX HDO (hydrodeoxygenation) over a Pd/HBEA catalyst in a batch reactor at 250°C. The effects of hydrogen pressure from 10 to 40 bar, catalyst/DX ratio from ½ to 2, and reaction time 0–24 h were investigated. A range of conditions for complete hydrodeoxygenated DX into alkanes with a Pd/HBEA catalyst was found. In these conditions, a low coke yield with water as the principal deoxygenated product was obtained. Further, higher amounts of alkanes containing seven or more carbons (A7+) were favored at 30 bar of hydrogen pressure, Cat/DX ratio = 2, and short reaction time. Products analysis that accompanied the above variations during reaction time led to general insights into reaction pathways. First, in the presence of DX, an effective n-hexane conversion was not observed on experiments of low catalyst/DX ratio (½) or in the initial period of high Cat/DX ratio, suggesting DX is much more successful than n-hexane to compete for active sites. Then, the formation of a pool of oxygenated compounds, such as furans, ketones, and carboxylic acids, along with lighter and heavier alkanes was observed. Hence, the aforementioned oxygenates may undergo reactions, such as aldol condensation with subsequent hydrodeoxygenation reaction, generating heavier alkanes.
Cardiac and Pulmonary Vascular Remodeling in Endurance Open Water Swimmers Assessed by Cardiac Magnetic Resonance: Impact of Sex and Sport Discipline
Authors: Martínez Vanessa , Sanz-de la Garza María , Domenech-Ximenos Blanca , Fernández César , García-Alvarez Ana , Prat-González Susanna , Yanguas Carles , Sitges Marta 
Published: August 2021

Background: The cardiac response to endurance exercise has been studied previously, and recent reports have described the extension of this remodeling to the pulmonary vasculature. However, these reports have focused primarily on land-based sports and few data are available on exercise-induced cardio-pulmonary adaptation in swimming. Nor has the impact of sex on this exercise-induced cardio-pulmonary remodeling been studied in depth. The main aim of our study was to evaluate cardiac and pulmonary circulation remodeling in endurance swimmers. Among the secondary objectives, we evaluate the impact of sex and endurance sport discipline on this cardio-pulmonary remodeling promoted by exercise training.Methods:Resting cardiovascular magnetic resonance imaging was performed in 30 healthy well-trained endurance swimmers (83.3% male) and in 19 terrestrial endurance athletes (79% male) to assess biventricular dimensions and function. Pulmonary artery dimensions and flow as well as estimates of pulmonary vascular resistance (PVR) were also evaluated.Results:In relation to the reference parameters for the non-athletic population, male endurance swimmers had larger biventricular and pulmonary artery size (7.4 ± 1.0 vs. 5.9 ± 1.1 cm2, p &lt; 0.001) with lower biventricular ejection fraction (EF) (left ventricular (LV) EF: 58 ± 4.4 vs. 67 ± 4.5 %, p &lt; 0.001; right ventricular (RV) EF: 60 ± 4 vs. 66 ± 6 %, p &lt; 0.001), LV end-diastolic volume (EDV): 106 ± 11 vs. 80 ± 9 ml/m2, p &lt; 0.001; RV EDV: 101 ± 14 vs. 83 ± 12 ml/m2, p &lt; 0.001). Significantly larger LV volume and lower LV EF were also observed in female swimmers (LV EF: 60 ± 5.3 vs. 67 ± 4.6 %, p = 0.003; LV EDV: 90 ± 17.6 vs. 75± 8.7 ml/m2, p = 0.002). Compared to terrestrial endurance athletes, swimmers showed increased LV indexed mass (75.0 ± 12.8 vs. 61.5 ± 10.0 g/m2, p &lt; 0.001). The two groups of endurance athletes had similar pulmonary artery remodeling.Conclusions: Cardiac response to endurance swimming training implies an adaptation of both ventricular and pulmonary vasculature, as in the case of terrestrial endurance athletes. Cardio-pulmonary remodeling seems to be less extensive in female than in male swimmers.
Ethics in Design and Implementation of Technologies for Workplace Health Promotion: A Call for Discussion
Authors: Roossien Charlotte Christina , de Jong Marlon , Bonvanie Anne Maria , Maeckelberghe Els Lisette Maria 
Published: August 2021

Aim:This study aims to initiate discussion on the ethical issues surrounding the development and implementation of technologies for workplace health promotion. We believe this is a neglected topic and such a complex field of study that we cannot come up with solutions easily or quickly. Therefore, this study is the starting point of a discussion about the ethics of and the need for policies around technologies for workplace health promotion.Method:Based on a literature review, the present study outlines current knowledge of ethical issues in research, development, and implementation of technologies in the workplace. Specifically, the focus is on two ethical issues that play an important role in the worker–employer relation: privacy and autonomy.Application:Two cases indicative for a multidisciplinary project aimed at developing and evaluating sensor and intervention technologies that contribute to keeping ageing workers healthy and effectively employable are explored. A context-specific approach of ethics is used to investigate ethical issues during the development and implementation of sensor and intervention technologies. It is a holistic approach toward the diverse field of participants and stakeholders, and the diversity in perceptions of relevant values, depending on their respective professional languages.Discussion:The results show how protecting the privacy and autonomy of workers cannot be seen as stand-alone issues, but, rather, there is interplay between these values, the work context, and the responsibilities of workers and employers. Consequently, technologies in this research project are designed to improve worker conscientious autonomy, while concurrently creating balance between privacy and health, and assigning responsibilities to appropriate stakeholders.Conclusion:Focusing on a contextual conceptualisation of the ethical principles in the design and implementation of digital health technologies helps to avoid compartmentalization, out-of-context generalisation, and neglect of identifying responsibilities. Although it is a long reiterative process in which all stakeholders need to be included in order to assess all ethical issues sufficiently, this process is crucial to achieving the intended goal of a technology. Having laid out the landscape and problems of ethics around technologies for workplace health promotion, we believe policies and standards, and a very overdue discussion about these, are needed.
Application of the Modified PLUM Method to a Dense Seismic Intensity Network of a Local Government in Japan: A Case Study on Tottori Prefecture
Authors: Kagawa Takao 
Published: August 2021

An application of the PLUM (Propagation of Local Undamped Motion) method to real-time seismic intensity distribution from a dense seismic intensity network maintained by a local government in Japan is demonstrated. The JMA (Japan Meteorological Agency) has employed the PLUM method from March 2018 as a supplement to the traditional EEW (Earthquake Early Warning) which requires hypocenter determination. A dense observation network is desirable for upgrading accuracy and immediateness of EEW including the PLUM method. Seismic intensity meters in Tottori Prefecture, Japan, are suitable for the purpose because they have been improved to broadcast packets with peak ground acceleration and JMA seismic intensity at every 1 s. Also, 34 seismic intensity meters are installed in the target area while only six observation sites are used for the EEW by the JMA. The packet data are received at Tottori University, and the modified PLUM method considers wave propagation with damping from not only the observation points but also all evaluating grid points at a 1 km mesh. Additionally, P-wave amplitudes in preliminary tremors are also introduced to estimate seismic intensities from an empirical relationship. Applying the methodology to past earthquake data, more detailed and rapid evaluations of seismic intensity distribution are achieved. We expect the system will be utilized for earthquake disaster mitigation measures of local governments.
Identification of the Real Hub Gene and Construction of a Novel Prognostic Signature for Pancreatic Adenocarcinoma Based on the Weighted Gene Co-expression Network Analysis and Least Absolute Shrinkage and Selection Operator Algorithms
Authors: Yuan Qihang , Ren Jie , Wang Zhizhou , Ji Li , Deng Dawei , Shang Dong 
Published: August 2021

Background: Pancreatic adenocarcinoma (PAAD) has a considerably bad prognosis, and its pathophysiologic mechanism remains unclear. Thus, we aimed to identify real hub genes to better explore the pathophysiology of PAAD and construct a prognostic panel to better predict the prognosis of PAAD using the weighted gene co-expression network analysis (WGCNA) and the least absolute shrinkage and selection operator (LASSO) algorithms.Methods: WGCNA identified the modules most closely related to the PAAD stage and grade based on the Gene Expression Omnibus. The module genes significantly associated with PAAD progression and prognosis were considered as the real hub genes. Eligible genes in the most significant module were selected for construction and validation of a multigene prognostic signature based on the LASSO-Cox regression analysis in The Cancer Genome Atlas and the International Cancer Genome Consortium databases, respectively.Results: The brown module identified by WGCNA was most closely associated with the clinical characteristics of PAAD. Scaffold attachment factor B (SAFB) was significantly associated with PAAD progression and prognosis, and was identified as the real hub gene of PAAD. Moreover, both transcriptional and translational levels of SAFB were significantly lower in PAAD tissues compared with normal pancreatic tissues. In addition, a novel multigene-independent prognostic signature consisting of SAFB, SP1, and SERTAD3 was identified and verified. The predictive accuracy of our signature was superior to that of previous studies, especially for predicting 3- and 5-year survival probabilities. Furthermore, a prognostic nomogram based on independent prognostic variables was developed and validated using calibration curves. The predictive ability of this nomogram was also superior to the well-established AJCC stage and histological grade. The potential mechanisms of different prognoses between the high- and low-risk subgroups were also investigated using functional enrichment analysis, GSEA, ssGSEA, immune checkpoint analysis, and mutation profile analysis.Conclusion: SAFB was identified as the real hub gene of PAAD. A novel multigene-independent prognostic signature was successfully identified and validated to better predict PAAD prognosis. An accurate nomogram was also developed and verified to aid in the accurate treatment of tumors, as well as in early intervention.
Maternal Health Care Among Refugees and Host Communities in Northern Uganda: Access, Quality, and Discrimination
Authors: Rustad Siri Aas , Binningsbø Helga Malmin , Gjerløw Haakon , Mwesigye Francis , Odokonyero Tony , Østby Gudrun 
Published: August 2021

Introduction: Uganda is one of the largest refugee-hosting nations in the world, with the majority of the refugees having fled South Sudan. In the early 2000's the local government and refugee health systems were merged to create a more equal and integrated system for refugees and the host population. Our aim is to investigate whether mothers from the two groups experience the same access to and quality of maternal health services, and whether refugee- and host-community mothers perceive the maternal health services differently.Methods: In November–December 2019, we conducted a household survey of 1,004 Ugandan nationals and South Sudanese refugee mothers aged 15–49 in the West Nile region covering the districts of Arua, Yumbe, and Adjumani, and elicited information on access to maternal health care services, perceptions of the quality of services, and feelings of discrimination. The data was then analyzed using Ordinary Least Squares and logistic regression.Results: Our analyses do not reveal large differences between refugees and the host community in terms of access to and the quality of maternal health services. Results from bivariate models indicate that refugee mothers are 6% points less likely to receive antenatal care (p-value &lt; 0.05) but are 8% points more likely to give birth at a health facility (p-value &lt; 0.05). Refugee mothers are generally less satisfied with how they were treated during antenatal care (0.132 lower average value on a Likert scale, p-value &lt; 0.01). Refugee mothers are also 4% points more likely to feel discriminated against during ANC compared to their counterparts in the host community (p-value &lt; 0.05).Discussion: The way women feel treated at the health facility during maternal health care is an important aspect of quality care. While there seems to be equal access to resources between refugees and host community mothers in Northern Uganda in terms of access to and quality of care, there is still a discrepancy between the two groups in terms of how the women feel treated. Policymakers and practitioners in the health sector should pay attention to these perceived inequalities between refugees and women from the host communities to ensure equally inclusive treatment across groups.
Autologous Dendritic Cells in Combination With Chemotherapy Restore Responsiveness of T Cells in Breast Cancer Patients: A Single-Arm Phase I/II Trial
Authors: Bernal-Estévez David A. , Ortíz Barbosa Mauren A. , Ortíz-Montero Paola , Cifuentes Claudia , Sánchez Ramiro , Parra-López Carlos A. 
Published: August 2021

IntroductionAnimal studies and preclinical studies in cancer patients suggest that the induction of immunogenic cell death (ICD) by neoadjuvant chemotherapy with doxorubicin and cyclophosphamide (NAC-AC) recovers the functional performance of the immune system. This could favor immunotherapy schemes such as the administration of antigen-free autologous dendritic cells (DCs) in combination with NAC-AC to profit as cryptic vaccine immunogenicity of treated tumors.ObjectiveTo explore the safety and immunogenicity of autologous antigen-free DCs administered to breast cancer patients (BCPs) in combination with NAC-AC.Materials and MethodsA phase I/II cohort clinical trial was performed with 20 BCPs treated with NAC-AC [nine who received DCs and 11 who did not (control group)]. The occurrence of adverse effects and the functional performance of lymphocytes from BCPs before and after four cycles of NAC-AC receiving DCs or not were assessed using flow cytometry and compared with that from healthy donors (HDs). Flow cytometry analysis using manual and automated algorithms led us to examine functional performance and frequency of different lymphocyte compartments in response to a stimulus in vitro. This study was registered at clinicaltrials.gov (NCT03450044).ResultsNo grade II or higher adverse effects were observed associated with the transfer of DCs to patients during NAC-AC. Interestingly, in response to the in vitro stimulation, deficient phosphorylation of Zap70 and AKT proteins observed before chemotherapy in most patients’ CD4 T cells significantly recovered after NAC-AC only in patients who received DCs.ConclusionsThe transfer of autologous DCs in combination with NAC-AC in BCPs is a safe procedure. That, in BCPs, the administration of DCs in combination with NAC-AC favors the recovery of the functional capacity of T cells suggests that this combination may potentiate the adjuvant effect of ICD induced by NAC-AC on T cells and, hence, potentiate the immunogenicity of tumors as cryptic vaccines.
The Course of Carotid Plaque Vulnerability Assessed by Advanced Neurosonology
Authors: Aarli Sander Johan , Thomassen Lars , Waje-Andreassen Ulrike , Logallo Nicola , Kvistad Christopher Elnan , Næss Halvor , Fromm Annette 
Published: August 2021

Background: Carotid artery atherosclerosis is a major risk factor for ischemic stroke. This risk is related to plaque vulnerability and is characterized by plaque morphology, intraplaque neovascularization, and cerebral microembolization. Advanced neurosonology can identify vulnerable plaques and aid in preventing subsequent stroke. We aimed to assess the time course of cerebral microembolization and intraplaque neovascularization during 6 months of follow-up and to explore the utility of advanced neurosonology in patients with acute cerebral ischemia.Methods: Fifteen patients with acute cerebral ischemia and carotid artery plaques underwent comprehensive extra- and intracranial ultrasound examinations, including microemboli detection and contrast-enhanced ultrasound. The examinations were repeated after 3 and 6 months.Results: We examined 28 plaques in 15 patients. The ultrasonographic features of plaque vulnerability were frequent in symptomatic and asymptomatic plaques. There were no significant differences in stenosis degree, plaque composition, plaque surface, neovascularization, or cerebral microembolization between symptomatic and asymptomatic plaques, but symptomatic plaques had a higher number of vulnerable features. None of the patients had recurrent clinical stroke or transient ischemic attack during the follow-up period. We observed a decrease in cerebral microembolization at 6 months, but no significant change in intraplaque neovascularization.Conclusions: In patients with acute cerebral ischemia and carotid artery plaques, cerebral microembolization decreased during 6 months of follow-up, indicating plaque stabilization.Clinical Trial Registration:ClinicalTrial.gov, identifier NCT02759653.