bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ordinal Trees and Random Forests: Score-Free Recursive Partitioning and Improved Ensembles
Authors: Tutz Gerhard 
Published: December 2021

AbstractExisting ordinal trees and random forests typically use scores that are assigned to the ordered categories, which implies that a higher scale level is used. Versions of ordinal trees are proposed that take the scale level seriously and avoid the assignment of artificial scores. The construction principle is based on an investigation of the binary models that are implicitly used in parametric ordinal regression. These building blocks can be fitted by trees and combined in a similar way as in parametric models. The obtained trees use the ordinal scale level only. Since binary trees and random forests are constituent elements of the proposed trees, one can exploit the wide range of binary trees that have already been developed. A further topic is the potentially poor performance of random forests, which seems to have been neglected in the literature. Ensembles that include parametric models are proposed to obtain prediction methods that tend to perform well in a wide range of settings. The performance of the methods is evaluated empirically by using several data sets.
Phospholipid fatty acids in soil—drawbacks and future prospects
Authors: Joergensen Rainer Georg 
Published: December 2021

Abstract
The current opinion and position paper highlights (1) correct assignation of indicator phospholipid fatty acids (PLFA), (2) specificity and recycling of PLFA in microorganisms, and (3) complete extraction and detection of PLFA. The straight-chain PLFA 14:0, 15:0, 16:0, and 17:0 occur in all microorganisms, i.e., also in fungi and not only in bacteria. If the phylum Actinobacteria is excluded from the group of Gram-positive bacteria, all remaining bacteria belong to the bacterial phylum Firmicutes, which should be considered. The PLFA 16:1ω5 should be used as an indicator for the biomass of arbuscular mycorrhizal fungi (AMF) as there is no experimental evidence that they occur in marked amounts in Gram-negative bacteria. Fungal PLFA should embrace the AMF-specific 16:1ω5. In the presence of plants, ergosterol should be used instead of the PLFA 18:2ω6,9 and 18:1ω9 as fungal indicators for Mucoromycotina, Ascomycota, and Basidiomycota. The majority of indicator PLFA are not fully specific for a certain microbial group. This problem might be intensified by recycling processes during decomposition to an unknown extent. Soil handling and extraction conditions should be further optimized. The reliability and accuracy of gas chromatographic separation need to be regularly checked against unintentional variations. PLFA analysis will still be of interest over the next decades as an important independent control of DNA-based methods.
Stenting techniques for coronary bifurcation disease: a systematic review and network meta-analysis demonstrates superiority of double-kissing crush in complex lesions
Authors: Wang Rui , Ding Yaodong , Yang Jiaxin , Wang Kexin , Gao Wen , Fang Zhe , Zhou Yujie , Ge Hailong 
Published: December 2021

Abstract
Objective
This study was aimed to compare different stenting techniques for coronary bifurcation disease (CBD).

Background
Percutaneous coronary intervention (PCI) remains controversial for CBD; over the years, several stent techniques for bifurcation lesions have been used. Current guidelines recommend a provisional single-stent strategy as the preferred method for coronary artery bifurcation lesions. However, several randomized controlled trials (RCT) indicated that two-stent techniques showed better clinical outcomes.

Methods
We systematically searched Embase, PubMed, and Web of Science to include RCTs. The primary endpoint was the major adverse cardiovascular event (MACE). Secondary outcomes were cardiac death, myocardial infarction (MI), target-lesion or target-vessel revascularization (TLR or TVR), and definite or probable stent thrombosis (ST). Finally, we used 26 RCTs and a total of 7257 individuals were randomly assigned to one of the 6 stent techniques and included in this network meta-analysis.

Results
In our network meta-analysis, double-kissing (DK) crush was significantly more superior to other 5 stent techniques in MACEs: OR vs. provisional 0.40 (95% CI 0.28–0.55); vs. culotte 0.40 (95% CI 0.26–0.60). DK crush ranked the most effective treatment for MACE (100%), MI (75%), ST (83%), and TLR (100%) in the rank probabilities analysis. In patients with complex bifurcation lesion defined by DEFINITION criteria, DK crush was notably more efficacious than provisional, culotte, and T-stenting/T-stenting and protrusion (TAP) in MACEs (OR vs. provisional 0.26, 95% CI 0.13–0.52) and TLR (OR vs. provisional 0.24, 95% CI 0.10–0.58).

Conclusion
Compared with other stenting techniques, DK crush had a lower incidence of MACEs in CBD. DK crush was significantly associated with a lower rate of MACEs in patients with complex bifurcation lesions defined by the DEFINITION criterion.

Graphical abstract
Experimental characterisation of porcine subcutaneous adipose tissue under blunt impact up to irreversible deformation
Authors: Lanzl Felicitas , Duddeck Fabian , Willuweit Saskia , Peldschus Steffen 
Published: December 2021

Abstract
A deeper understanding of the mechanical characteristics of adipose tissue under large deformation is important for the analysis of blunt force trauma, as adipose tissue alters the stresses and strains that are transferred to subjacent tissues. Hence, results from drop tower tests of subcutaneous adipose tissue are presented (i) to characterise adipose tissue behaviour up to irreversible deformation, (ii) to relate this to the microstructural configuration, (iii) to quantify this deformation and (iv) to provide an analytical basis for computational modelling of adipose tissue under blunt impact. The drop tower experiments are performed exemplarily on porcine subcutaneous adipose tissue specimens for three different impact velocities and two impactor geometries. An approach based on photogrammetry is used to derive 3D representations of the deformation patterns directly after the impact. Median values for maximum impactor acceleration for tests with a flat cylindrical impactor geometry at impact velocities of 886 mm/s, 1253 mm/s and 2426 mm/s amount to 61.1 g, 121.6 g and 264.2 g, respectively, whereas thickness reduction of the specimens after impact amount to 16.7%, 30.5% and 39.3%, respectively. The according values for tests with a spherically shaped impactor at an impact velocity of 1253 mm/s are 184.2 g and 78.7%. Based on these results, it is hypothesised that, in the initial phase of a blunt impact, adipose tissue behaviour is mainly governed by the behaviour of the lipid inside the adipocytes, whereas for further loading, contribution of the extracellular collagen fibre network becomes more dominant.
Topographical functional correlates of interindividual differences in executive functions in young healthy twins
Authors: Menardi Arianna , Reineberg Andrew E. , Smith Louisa L. , Favaretto Chiara , Vallesi Antonino , Banich Marie T. , Santarnecchi Emiliano 
Published: December 2021

AbstractExecutive functions (EF) are a set of higher-order cognitive abilities that enable goal-directed behavior by controlling lower-level operations. In the brain, those functions have been traditionally associated with activity in the Frontoparietal Network, but recent neuroimaging studies have challenged this view in favor of more widespread cortical involvement. In the present study, we aimed to explore whether the network that serves as critical hubs at rest, which we term network reliance, differentiate individuals as a function of their level of EF. Furthermore, we investigated whether such differences are driven by genetic as compared to environmental factors. For this purpose, resting-state functional magnetic resonance imaging data and the behavioral testing of 453 twins from the Colorado Longitudinal Twins Study were analyzed. Separate indices of EF performance were obtained according to a bifactor unity/diversity model, distinguishing between three independent components representing: Common EF, Shifting-specific and Updating-specific abilities. Through an approach of step-wise in silico network lesioning of the individual functional connectome, we show that interindividual differences in EF are associated with different dependencies on neural networks at rest. Furthermore, these patterns show evidence of mild heritability. Such findings add knowledge to the understanding of brain states at rest and their connection with human behavior, and how they might be shaped by genetic influences.
Evidence for infection in intervertebral disc degeneration: a systematic review
Authors: Granville Smith Isabelle , Danckert Nathan P. , Freidin Maxim B. , Wells Philippa , Marchesi Julian R. , Williams Frances M. K. 
Published: December 2021

Abstract
Purpose
Back pain is a major problem worldwide and is linked to intervertebral disc degeneration and Modic change. Several studies report growth of bacteria following extraction of degenerate discs at spine surgery. A pathophysiological role for infection in back pain has been proposed.

Method
We conducted a PRISMA systematic review. MEDLINE, PubMed, Scopus and Web of Science were searched with the terms Modic change, intervertebral dis*, bacteria, microb*, and infect*. Date limits of 2001–2021 were set. Human studies investigating the role of bacteria in disc degeneration or Modic change in vertebrae were included.

Results
Thirty-six articles from 34 research investigations relating to bacteria in human degenerate discs were found. Cutibacterium acnes was identified in pathological disc material. A ‘candidate bacterium’ approach has been repeatedly adopted which may have biased results to find species a priori, with disc microbial evidence heavily weighted to find C. acnes.

Conclusion
Evidence to date implicates C. acnes identified through culture, microscopy and sequencing, with some suggestion of diverse bacterial colonisation in the disc. This review found studies which used culture methods and conventional PCR for bacterial detection.
Further agnostic investigation using newer methods should be undertaken.
The hot spots conjecture can be false: some numerical examples
Authors: Kleefeld Andreas 
Published: December 2021

AbstractThe hot spots conjecture is only known to be true for special geometries. This paper shows numerically that the hot spots conjecture can fail to be true for easy to construct bounded domains with one hole. The underlying eigenvalue problem for the Laplace equation with Neumann boundary condition is solved with boundary integral equations yielding a non-linear eigenvalue problem. Its discretization via the boundary element collocation method in combination with the algorithm by Beyn yields highly accurate results both for the first non-zero eigenvalue and its corresponding eigenfunction which is due to superconvergence. Additionally, it can be shown numerically that the ratio between the maximal/minimal value inside the domain and its maximal/minimal value on the boundary can be larger than 1 + 10− 3. Finally, numerical examples for easy to construct domains with up to five holes are provided which fail the hot spots conjecture as well.
An application of symplectic integration for general relativistic planetary orbitography subject to non-gravitational forces
Authors: O’Leary Joseph , Barriot Jean-Pierre 
Published: December 2021

AbstractSpacecraft propagation tools describe the motion of near-Earth objects and interplanetary probes using Newton’s theory of gravity supplemented with the approximate general relativisticn-body Einstein–Infeld–Hoffmann equations of motion. With respect to the general theory of relativity and the long-standing recommendations of the International Astronomical Union for astrometry, celestial mechanics and metrology, we believe modern orbitography software is now reaching its limits in terms of complexity. In this paper, we present the first results of a prototype software titled General Relativistic Accelerometer-based Propagation Environment (GRAPE). We describe the motion of interplanetary probes and spacecraft using extended general relativistic equations of motion which account for non-gravitational forces using end-user supplied accelerometer data or approximate dynamical models. We exploit the unique general relativistic quadratic invariant associated with the orthogonality between four-velocity and acceleration and simulate the perturbed orbits for Molniya, Parker Solar Probe and Mercury Planetary Orbiter-like test particles subject to a radiation-like four-force. The accuracy of the numerical procedure is maintained using a 5-stage,$$10^\mathrm{th}$$10th-order structure-preserving Gauss collocation symplectic integration scheme. GRAPE preserves the norm of the tangent vector to the test particle worldline at the order of$$10^{-32}$$10-32.
Bregman primal–dual first-order method and application to sparse semidefinite programming
Authors: Jiang Xin , Vandenberghe Lieven 
Published: December 2021

AbstractWe present a new variant of the Chambolle–Pock primal–dual algorithm with Bregman distances, analyze its convergence, and apply it to the centering problem in sparse semidefinite programming. The novelty in the method is a line search procedure for selecting suitable step sizes. The line search obviates the need for estimating the norm of the constraint matrix and the strong convexity constant of the Bregman kernel. As an application, we discuss the centering problem in large-scale semidefinite programming with sparse coefficient matrices. The logarithmic barrier function for the cone of positive semidefinite completable sparse matrices is used as the distance-generating kernel. For this distance, the complexity of evaluating the Bregman proximal operator is shown to be roughly proportional to the cost of a sparse Cholesky factorization. This is much cheaper than the standard proximal operator with Euclidean distances, which requires an eigenvalue decomposition.
Reproductive health and endocrine disruption in smallmouth bass (Micropterus dolomieu) from the Lake Erie drainage, Pennsylvania, USA
Authors: Walsh Heather L. , Rafferty Sean D. , Gordon Stephanie E. , Blazer Vicki S. 
Published: December 2021

AbstractSmallmouth bass Micropterus dolomieu were sampled from three sites within the Lake Erie drainage (Elk Creek, Twentymile Creek, and Misery Bay, an embayment in Presque Isle Bay). Plasma, tissues for histopathological analyses, and liver and testes preserved in RNALater® were sampled from 30 smallmouth bass (of both sexes) at each site. Liver and testes samples were analyzed for transcript abundance with Nanostring nCounter® technology. Evidence of estrogenic endocrine disruption was assessed by the presence and severity of intersex (testicular oocytes; TO) and concentrations of plasma vitellogenin in male fish. Abundance of 17 liver transcripts associated with reproductive function, endocrine activity, and contaminant detoxification pathways and 40 testes transcripts associated with male and female reproductive function, germ cell development, and steroid biosynthesis were also measured. Males with a high rate of TO (87–100%) and plasma vitellogenin were noted at all sites; however, TO severity was greatest at the site with the highest agricultural land cover. Numerous transcripts were differentially regulated among the sites and patterns of transcript abundance were used to better understand potential risk factors for estrogenic endocrine disruption. The results of this study suggest endocrine disruption is prevalent in this region and further research would benefit to identify the types of contaminants that may be associated with the observed biological effects.
Stakeholder consultations on small-scale irrigation schemes’ constraints in Zimbabwe
Authors: Muhoyi Edgar , Mbonigaba Josue 
Published: December 2021

AbstractSmall-scale irrigation schemes (SSIS) have been considered a solution to viability challenges in drought-stricken farming areas in developing countries. However, the schemes face severe constraints. In this paper, relevant constraints are identified and ranked in terms of how serious the limitations are from the perspective of stakeholders in drought-prone areas of the Chipinge District in Zimbabwe. Information for the study was gained through a questionnaire and focus group discussions with small-scale irrigation farmers as well as key informant interviews with government irrigation officials, irrigation managers and members of the local community leadership. The information was garnered between August and December in 2017 with the analysis conducted using descriptive statistics and thematic analysis, guided by the Theory of Constraints and classified in the political, economic, social, technological, environmental and legal (PESTEL) framework. Results indicated that SSIS are important in the drought-prone areas of the Chipinge District regarding food security and income generation. However, technical issues bedevilling the schemes are considered to be the most challenging limitations. The most important constraints—ranked in descending order of gravity—are technical, economic, social, environmental, legal and political challenges. Based on these findings, the research strongly recommends modernising small-scale irrigation schemes’ infrastructure, among other issues, as a priority in Zimbabwe's drought-prone areas.
Particle energization in space plasmas: towards a multi-point, multi-scale plasma observatory
Authors: Retinò Alessandro , Khotyaintsev Yuri , Le Contel Olivier , Marcucci Maria Federica , Plaschke Ferdinand , Vaivads Andris , Angelopoulos Vassilis , Blasi Pasquale , Burch Jim , De Keyser Johan , Dunlop Malcolm , Dai Lei , Eastwood Jonathan , Fu Huishan , Haaland Stein , Hoshino Masahiro , Johlander Andreas , Kepko Larry , Kucharek Harald , Lapenta Gianni , Lavraud Benoit , Malandraki Olga , Matthaeus William , McWilliams Kathryn , Petrukovich Anatoli , Pinçon Jean-Louis , Saito Yoshifumi , Sorriso-Valvo Luca , Vainio Rami , Wimmer-Schweingruber Robert 
Published: December 2021

AbstractThis White Paper outlines the importance of addressing the fundamental science theme “How are charged particles energized in space plasmas” through a future ESA mission. The White Paper presents five compelling science questions related to particle energization by shocks, reconnection, waves and turbulence, jets and their combinations. Answering these questions requires resolving scale coupling, nonlinearity, and nonstationarity, which cannot be done with existing multi-point observations. In situ measurements from a multi-point, multi-scale L-class Plasma Observatory consisting of at least seven spacecraft covering fluid, ion, and electron scales are needed. The Plasma Observatory will enable a paradigm shift in our comprehension of particle energization and space plasma physics in general, with a very important impact on solar and astrophysical plasmas. It will be the next logical step following Cluster, THEMIS, and MMS for the very large and active European space plasmas community. Being one of the cornerstone missions of the future ESA Voyage 2050 science programme, it would further strengthen the European scientific and technical leadership in this important field.
Can Mӧssbauer methods of classifying ordinary chondrites help to identify non-representative samples of these meteorites?
Authors: Jakubowska Martyna , Gałązka-Friedman Jolanta , Woźniak Marek , Bogusz Patrycja , Karwowski Łukasz , Duda Przemysław 
Published: December 2021

AbstractMössbauer spectra of nonweathered ordinary chondrites consist of four main mineral phases: olivines, pyroxenes, metallic phase and troilite. These minerals represent more than 95% of the whole mass of an ordinary chondrite. Distribution of these mineral phases in micro-scale is not homogeneous. Nevertheless, preparation of representative sample of ordinary chondrite for Mössbauer measurements is possible. To do that a part of 1 g nonweathered material, selected from inside of meteorite without any specific intention is needed. The Warsaw group has been working on investigation of meteorites for 25 years and has analysed about 150 Mössbauer spectra of various meteorites. Among them we found 15 spectra, which could be suspected of being non-representative. These spectra were obtained from Baszkówka, Amber, Bjurböle, Krasnoi-Ugol and Chelyabinsk meteorites. The analysis of how the samples of meteorites were selected for investigation, has shown that the non-representativeness of samples may be due to: intentional choice of sample, preparation of sample from a too small part of material or the use of non-credible source of meteoritic samples. For confirmation of these assumptions, we used a new method of classification of ordinary chondrites – the 4M method. It turned out that this method is a very useful tool for investigation of non-representative samples of equilibrated ordinary chondrites.
Childhood ADHD and Executive Functioning: Unique Predictions of Early Adolescent Depression
Authors: Fenesy Michelle C. , Lee Steve S. 
Published: December 2021

AbstractGiven the increasing prevalence of adolescent depression, identification of its early predictors and elucidation of the mechanisms underlying its individual differences is imperative. Controlling for baseline executive functioning (EF), we tested separate ADHD dimensions (i.e., inattention, hyperactivity-impulsivity) as independent predictors of early adolescent depression, including temporally-ordered causal mediation by academic functioning and social problems, using structural equation modeling. At baseline, participants consisted of 216 children (67% male) ages 6–9 years old with (n = 112) and without (n = 104) ADHD who subsequently completed Wave 2 and 3 follow-ups approximately two and four years later, respectively. Predictors consisted of separate parent and teacher ratings of childhood ADHD and laboratory-based assessments of key EF domains. At Wave 2, parents and teachers completed normed rating scales of youth academic and social functioning; youth completed standardized assessments of academic achievement. At Wave 3, youth self-reported depression. Baseline inattention positively predicted early adolescent depression whereas childhood hyperactivity-impulsivity and EF did not. Neither academic nor social functioning significantly mediated predictions of depression from baseline ADHD and EF. We consider prediction of early adolescent depression from inattention, including directions for future intervention and prevention research.