bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Bismuth in Irritable Bowel Syndrome
Authors: Ilchishina T. A. 
Published: October 2021

Aim. An evidence review on use of bismuth in irritable bowel syndrome.Key points. Irritable bowel syndrome (IBS) is a common functional disorder significantly impacting the quality of life and social status, i.a., through frequent manifestations of diarrhea. Postinfectious IBS emerges after a bacterial, pro-tozoan or viral intestinal disease. The new coronavirus pandemic supposedly affects most factors involved in functional disorder developments and may serve a fuelling cause of postinfectious IBS. Bismuth salts accumulate cytoprotective, anti-inflammatory and antibacterial properties. Therapeutic efficacy of bismuth compounds has been demonstrated in treatment of diarrhea-accompanied diseases of various etiology, including postinfectious IBS. The use of therapeutic-dosed bismuth preparations is safe and well tolerated by patients.Conclusion. Use of bismuth may be considered a treatment and prevention approach in diarrhea-predominant IBS, both in monotherapy and combined regimens.
Diagnosing MALT Gastric Lymphoma in Gastroenterologist’s Practice, a Clinical Observation
Authors: Selezneva E. Ya. , Shcherbakova N. A. , Embutnieks Yu. V. , Bystrovskaya E. V. , Khomeriki S. G. 
Published: October 2021

Aim.A clinical case description to highlight challenges in diagnosing MALT lymphoma presented in infiltrative ulcer-ative lesions.Key points. A 60-yo patient was admitted to the Loginov Moscow Clinical Scientific Centre with epigastric pain and an 18 kg weight loss over past 4 months. A history of repeated outpatient endoscopic examinations revealing subse-quently ulcerative and infiltrative ulcerative gastric lesions of unestablished origin. A complex examination combin-ing oesophagogastroduodenoscopy (OGDS), endosonography (EUS), multislice computed tomography (MSCT), morphological and immunohistochemical (IHC) assays elicited the MALT gastric lymphoma IIE stage involving para-gastric and intraperitoneal lymph nodes. The first treatment stage included line-1 eradication therapy, rabeprazole 20 mg x 2 times a day, amoxicillin 1000 mg x 2 times a day, clarithromycin 500 mg x 2 times a day, bismuth tripotas-sium dicitrate 240 mg x 2 times a day — for 14 days. Accounting for the process prevalence and stage, six courses of R-CHOP polychemotherapy (PCT) were ordered by haematologist.Conclusion.This observation demonstrates a targeted-biopsy endoscopic examination followed by morphological, IHC, EUS (for invasion depth) and MSCT (for process advancement) assays to be decisive in differential diagnosis of ulcerative and infiltrative ulcerative gastric lesions.
Diagnosis of Functional Gastrointestinal Disorders and Choice of Treatment Regimen in Constipation Patients
Authors: Maev I. V. , Kazyulin A. N. , Kucheryavy Yu. A. , Cheryomushkin S. V. , Goncharenko A. Yu. , Gilyuk А. V. 
Published: October 2021

Aim. A practical review of functional gastrointestinal disorder diagnosis in constipation patients and the rationale for opting treatment.Key points. Functional constipation commonly afflicts different ages and negatively impacts the quality of life. The current diagnostic algorithm in chronic constipation includes the disease identification according to Rome Criteria IV, red-flag symptom detection and instrumental laboratory examination. Functional constipation is notably often associated with anorectal abnormalities that bear a diagnostic value to elaborate an apt treatment strategy. Anorectal manometry, rectal sensation and balloon expulsion tests are the well-studied and significant probing techniques for objective anorectal zone sensorimotor function assessment in patients with functional constipation. The article reviews modern diagnostic methods in functional defecation disorders.Conclusion. The examination and treatment algorithms presented will help improve diagnosis and apply the most suitable management in a constipation-associated functional digestive pathology.
Cost effectiveness analysis of universal varicella vaccination in the Russian Federation
Authors: Rudakova A. V. , Kharit S. M. , Babachenko I. V. , Konovalova L. N. , Rychkova S. V. , Uskov A. N. , Lobzin Yu. V. 
Published: October 2021

Varicella is a significant burden on society and the healthcare system.Objective: to analyze the cost effectiveness of universal vaccination of children against varicella.Material and methods. The analysis was carried out from the perspective of the healthcare system and societal perspective, based on epidemiological data for the Russian Federation. The effect was taken into account only in the vaccinated population. The time horizon of the study is 10 years. The amount of direct medical costs for treatment of varicella was calculated based on the rates of compulsory medical insurance in St. Petersburg in 2020. The cost of drug therapy in outpatient settings was calculated based on the weighted average retail price of prescribed drugs. The analysis of direct nonmedical and indirect costs was carried out taking into account statistical data on the Russian Federation and duration of temporary disability of family members of sick children. Costs and quality-adjusted life expectancy were discounted by 3.5% per year.Results. The average cost due to the disease in the Russian Federation is 43,139 rubles / patient, of which 8,5% is direct cost. Vaccination of 100,000 children will prevent 38,551 cases of varicella in 10 years. When analyzing from a social perspective, vaccination provides a reduction in costs compared to no vaccination, and the savings will amount to 10.1 thousand rubles per 1 vaccinated person.If vaccination coverage is 90%, taking into account the fact that the cohort of children in the Russian Federation at the age of 1 year is about 1.9 million people, the cost of vaccination will amount to about 8.1 billion rubles annually. At the same time, already 6 years after vaccination, the volume of averted budgetary costs will exceed the costs of vaccination.Conclusion. Universal varicella vaccination of children will reduce the incidence of the disease and reduce the budget costs associated with this disease.
Acute CoVID-19-associated bilateral neuropathy of the abducens nerve in a child
Authors: Voitenkov V. B. , Gorelik E. Yu. , Scripchenko N. V. , Marchenko N. V. , Klimkin A. V. , Bedova M. A. 
Published: October 2021

We have presented the first description of acute bilateral neuropathy of the abducens nerve associated with COVID-19 in a child.A boy aged 2 years 2 months acutely developed bilateral convergent strabismus, the next day fatigue, drowsiness, and a single vomiting not associated with food intake, were joined. A differential diagnosis was performed between brainstem encephalitis, other organic (non-inflammatory) lesions of the brain stem, and idiopathic bilateral neuropathy of the abducens nerves. According to laboratory data, mild lymphocytosis, mild eosinophilia were detected, according to polymerase chain reaction DNA of the herpes virus type 1/2, cytomegalovirus, herpes virus type 6, Epstein-Barr, tick-borne encephalitis, borrelia, anaplasma, RNA ehrlichia were not detected. IgM and IgG to tick-borne encephalitis were not detected. Neurophysiological and neuroimaging examinations did not reveal any pathology. On the 6th day of the disease, SARS-CoV-2 RNA was detected by polymerase chain reaction of the nasopharynx and oropharynx discharge. The final diagnosis was formulated. — bilateral neuropathy of the abducens nerves. Bilateral convergent paralytic strabismus. Concomitant diagnosis: new coronavirus infection, subclini-cal form (positive by polymerase chain reaction in the discharge from the throat and nose of the 2019-nCoV coronavirus (SARS-CoV-2) RNA). Decrease in the severity of strabismus was noted over time against the background of the therapy.Clinicians dealing with the COVID-19 should also pay attention to its ophthalmological manifestations and take into account that it can debut with them, as was in our case.
Genetic characteristics of group A rotaviruses circulating in the Orenburg region during various epidemic seasons
Authors: Denisyuk N. B. 
Published: October 2021

Objective. To analyze the genetic structure of rotaviruses of group A, circulating on the territory of the Orenburg region in different epidemic seasons.Materials and methods: The genetic structure of rotaviruses by G/P alleles was determined in 341 fecal samples of patients with gastroenteritis clinic under the age of 5 years in various epidemic seasons. ELISA and PCR methods were used. The typing of rotaviruses was conducted on the basis of the laboratory of molecular diagnostic and epidemiology of enteric infections of the Department molecular diagnostics Central research Institute of epidemiology.Results: The general genetic structure of group a rotaviruses circulating in the Orenburg region in the period from 2014—2020 was determined, expressed, by the frequencies of G/P alleles. The genetic potential of group a rotaviruses for the entire study period was represented by twelve variants of genotypes for G/P alleles, the leading role in the epidemic process was played by genotypes with the highest frequency of occurrence: G4[P]8, G9[P]8, G2[P]4, Mixt. The frequency of registration of combined forms of various rotavirus genotypes (Mixed forms) was 5,9%.Conclusion: The main and dominant genotypes, their regional diversity and inter-seasonal fluctuations are established. The spectrum of circulating rotavirus genotypes differed in different epidemic seasons, and their epidemic significance is shown.
Effect of In-office Bleaching on Color, Translucency, and Whiteness Variations in CAD-CAM Monolithic Materials
Authors: Peña RC , Simóes R , Ramos AC , Dovigo LN , Fonseca RG 
Published: October 2021

SUMMARY
Little is known about the impact of bleaching on the optical properties of computer-aided design and computer-aided manufactured (CAD-CAM) monolithic materials. The aim of the present study was to evaluate the effect of one session of in-office bleaching on stain removal, staining susceptibility, translucency, and whiteness variations of CAD-CAM monolithic materials. Disks were fabricated from Lava Ultimate (LU), Vita Enamic (VE), Vita Suprinity (VS), and IPS e.max CAD (IPS). A spectrophotometer was used to register Commission Internationale de l’Eclairage L*a*b* coordinates. For stain removal, 80 specimens from each material were assessed at baseline (R0) and after immersion in deionized water or coffee for 36.5 days followed or not by bleaching with 40% hydrogen peroxide (R1). For staining susceptibility, 80 specimens from each material were analyzed at baseline (R0’), and after having been bleached or not and immersed in deionized water or coffee (R1’). Both analyses were calculated as the color difference (ΔE00) between R1-R0 and R1’-R0’, respectively. Differences in translucency (ΔTP00) and whiteness (ΔWID) between R1-R0 and R1’-R0’ were also calculated. Data were analyzed by three-way ANOVA and the Games-Howell post hoc test (α=0.05). Clinical significance was based on 50%:50% perceptibility and acceptability thresholds for ΔE00, ΔTP00 and ΔWID, respectively. Surfaces were analyzed by scanning electron microscopy. Coffee increased ΔE00 in LU, VE, and VS, and decreased their translucency and whiteness, whereas the IPS had only its whiteness affected. Bleaching after immersion in coffee decreased ΔE00 in LU and VE, and increased translucency and whiteness of LU, VE, and VS. No effect was observed on IPS. Bleaching before immersion in coffee decreased translucency of LU, but within the acceptable interval, while VE exhibited lower ΔE00, and became more translucent and less dark. Both VS and IPS were not affected. One session of in-office bleaching benefited optical properties of the previously stained LU, VE, and VS, without increasing their susceptibility to staining or adversely providing clinically unacceptable variations in their translucency and whiteness. All variations exhibited by the IPS were below the perceptible threshold.
Better Glass-fiber Post Preservation in Teeth with Ferrule When Subjected to Chewing
Authors: Gré CP , Lise DP , Ramos RQ , Van Meerbeck B , Vieira LCC , Lopes GC 
Published: October 2021

SUMMARY

Objectives
To evaluate the influence of ferrule effect and mechanical fatigue aging on glass-fiber post push-out bond strength (PBS) to root-canal dentin at different root thirds of premolars.

Methods and Materials
Thirty-two sound maxillary premolar teeth were collected, and randomly assigned to two experimental groups (n=16): ‘Remaining Dentin Ferrule’ (RDF) = coronal crown cut 2.0 mm above the cementoenamel junction (CEJ); ‘Without Dentin Ferrule’ (WDF) = coronal crown cut at the cemento-enamel junction. Teeth were endodontically treated, post spaces were prepared up to 10.0-mm depth from CEJ, and glass-fiber posts were cemented using a dual-cure self-adhesive composite cement. Standardized cores were built using a light-cure composite, upon which tooth cores were prepared using a 1.5-mm taper ogival-end diamond bur. Crowns were handmade using self-cure acrylic resin and cemented using the aforementioned composite cement. Half of the specimens were subjected to 1,200,000 cycles of mechanical fatigue in a chewing simulator (F = ‘Fatigue’), while the other half were stored in distilled water at 37°C for 1 week (C = ‘Control’). All specimens were horizontally sectioned into 1.0-mm thick slices prior to PBS test; the failure modes were assessed using stereomicroscopy and scanning electron microscopy (SEM). Data were analyzed for each root third using two-way analysis of variance (ANOVA) followed by Tukey HSD post-hoc test; frequency distribution was compared by Chi-square test (α=0.05) and post-hoc comparisons with Bonferroni.

Results
The mean PBS in MPa (SD) were = RDF_F = 10.4 (2.9); WDF_F = 6.9 (1.7); RDF_C = 14.5 (2.7); WDF_C = 14.2 (2.9). Similar PBS were found for the root thirds. For all root thirds, significant differences were found for both the factors Dentin Ferrule and Fatigue, and their interaction (p&lt;0.05). The lowest PBS was found for specimens without dentin ferrule subjected to chewing fatigue (p&lt;0.001). Most failures occurred at the composite cement/dentin interface, followed by mixed and composite cement/glass-fiber post interfacial failures. There was a significant increase in mixed failures for the WDF_F group (p&lt;0.001).

Conclusion
Absence of 2.0-mm remaining dentin ferrule in premolars resulted in a higher decrease of the glass-fiber posts’ PBS to dentin after mechanical fatigue, irrespective of root third.
Minimally Invasive Multidisciplinary Restorative Approach to the Esthetic Zone Including a Single Discolored Tooth
Authors: Tsujimoto A , Jurado CA , Villalobos-Tinoco J , Fischer NG , Alresayes S , Sanchez-Hernandez RA , Watanabe H , Garcia-Godoy F 
Published: October 2021

SUMMARY

Objectives
The case report describes a minimally invasive, multidisciplinary approach to a single discolored anterior tooth, with internal bleaching using traditional Japanese paper (Washi), a gingivoplasty with a three-dimensional (3D) printed surgical guide, and ultrathin feldspathic porcelain veneers.

Clinical consideration
The patient’s primary concern was improving her smile. After clinical evaluation, internal tooth bleaching for the discolored tooth and gingivoplasty with restoration of the maxillary anterior six teeth and first premolars was recommended. The internal tooth whitening was accomplished with sodium perborate mixed with 30% hydrogen peroxide impregnated in Washi and sealed in the root canal with glass ionomer. Once the tooth bleaching was completed, the 3D printed surgical guide was placed in the patient’s maxillary anterior region and used to guide soft tissue recontouring. After 6 months, ultrathin feldspathic porcelain veneers were placed.

Conclusion
Well-planned restorative procedures combining internal tooth bleaching using Washi, gingivoplasty performed with electrosurgery using a 3D printed surgical guide, and ultrathin feldspathic porcelain veneers can achieve the desired results in the esthetic zone and remain successful for 4 years.
J.R.R. Tolkien: Pioneer of Worldbuilding
Authors: Rawal Ms. Rainysha , Banik Dr. Aparna 
Published: October 2021

This paper explains after analysing critical aspects why J. R. R. Tolkien’s efforts are the mere reason for generating huge interests among authors in Fantasy. Among the most prominent novels of 20th century, for considering excellence in any fantasy literature his works stood as a benchmark.
It also highlights about World Building. The greatest contribution belongs to Fantasy Literature is making of new worlds, providing new definition to fantasy and his esteem for different languages made him to use the Language as a constant to create the world from scratch. Tolkien may consider the creator of his own world – Middle-earth which acts as a Universe, it took around 60 years in the creation, has a deep meaning in everything which one can ever expect. He is a prolific artist and his created universe of own geography and history, flora and fauna, languages and cultures, physics and magic proved fine artist constructing the worlds.
UPAYA GURU MENINGKATKAN KOSAKATA ANAK MELALUI METODE BERMAIN PERAN DI TK ALKHAIRAAT 1 PUSAT PALU
Authors: Nurmita  , Nur Asmawaty  , Erniati  
Published: October 2021

Penelitian ini bertujuan untuk mengetahui upaya guru meningkatkan kosakata pada anak melalui metode bermain peran khususnya di sekolah Taman Kanak-kanak. Jenis penelitian yang di gunakan dalam penelitian ini adalah kualitatif deskriptif, yaitu suatu penelitian yang mendapatkan suatu gambaran secara sistematis, aktual dan akurat mengenai fakta dan perkembangan individu apa adanya. Teknik pengumpulan data yang didapatkan melalui observasi, wawancara, dan dokumentasi. Teknik analisis data yang digunakan adalah reduksi data, penyajian data, dan verifikasi data. Sedangkan keabsahan datanya akan diperkuat dengan melakukan teknik pemeriksaan. Dari hasil penelitian yang diperoleh menunjukan bahwa upaya guru dalam meningkatkan kosakata anak melalui metode bermain peran yaitu: Guru menyiapkan rencana pembelajaran harian (RPPH), guru memperlihatkan media gambar yang sesuai dengan tema, guru membicarakan alat-alat yang akan digunakan oleh anak untuk bermain peran, guru membagi tugas kepada anak sebelum bermain peran menurut kelompoknya agar tidak berebutan, guru mengumpulkan anak untuk diberi pengarahan, memberi aturan dalam permainana, mengabsen serta menghitung jumlah anak, guru hanya mengawasi/mendampingi anak dalam bermain. Adapun faktor pendukung dan penghambat guru dalam meningkatkan kosakata anak mealalui meode bermain peran yaitu: Kemampuan guru dalam menerapkan metode bermain peran, sarana dan prasarana, dan faktor pengambat terdapat pada beberapa anak yang jarang hadir di sekolah sehingga anak tersebut ketinggalan mengikuti kegiatan pembelajaran bermain peran di sekolah
Hate Crimes: Evaluation of Lithuanian Courts’ Decisions in the Light of the Practice of the European Court of Human Rights
Authors: Bilius Mindaugas , Navickienė Žaneta , Velička Vilius 
Published: October 2021

Abstract
In this article, the authors analyse the practice of the Lithuanian national courts and the European Court of Human Rights in hate crime cases, provide insights into the synergy between the decisions made by these courts, and suggest further improvement actions. This research shows that proving the circumstances surrounding various forms of hatred is quite complex, often lacking a more comprehensive, in-depth definition of the totality of circumstances by taking account of the need for special knowledge, the identification of guilt, and the system and intensity of actions. There is often a divide between criminal liability and the possibility of other countermeasures, especially when examining cases related to hate speech. Court decisions draw attention to the fact that it is necessary to consider the totality of the data collected, not individual data or individual fragments of circumstances. Among other things, the decisions emphasize the ultima ratio principle: whether criminal liability is an adequate measure in cases of hate speech. The topical issues examined in the article draw attention to the collection of significant data and the organization of investigations of these crimes, issues relating to proof and the emerging practice of the European Court of Human Rights and the Supreme Court of the Republic of Lithuania in this category of cases, highlighting the two main problematic aspects: first, the determination of the totality of objective and subjective features and second, the fact of identifying a real threat.
Pandemics in Cyberspace – Empire in Search of a Sovereign?
Authors: Gábriš Tomáš , Hamuľák Ondrej 
Published: October 2021

Abstract
Traditionally, the idea of a sovereign is being connected either with an absolutist ruler (later replaced by “the people”) at the national level, or the nation-state at the international level – at least in the conditions of the Westphalian system created in 1648. Today, on the contrary, we are witnessing a “post-” situation in many respects – post-modernism, post-positivism, but also post-statism – basically being a sort of return to the pre-Westphalian system (see Ondrej Hamuľák, “Lessons from the ‘Constitutional Mythology’ or How to Reconcile the Concept of State Sovereignty with European Integration,” DANUBE: Law, Economics and Social Issues Review Vol. 6, No. 2 (2015); or Danuta Kabat-Rudnicka, “Autonomy or Sovereignty: the Case of the European Union,” International and Comparative Law Review Vol. 20, No. 2 (2020)). However, paternalistic views, prevailing especially in times of crisis and uncertainty, desperately search for a sovereign to lead us from the crises. With regard to cyberattacks and insecurity in the cyberspace this means an effort to subordinate cyberspace to state sovereignty. Still, given the limitations of traditional state-based monopolies of power and legislation, the state as an “analogue sovereign” shrinks in the digital cyberspace rather to a co-sovereign, co-ordinator, or in feudal terms a “senior” vis-à-vis their vassals. The actual ensuring of the tasks of state as a “digital sovereign” is namely often being entrusted to non-state (essentially private-owned) entities, under the threat of legal sanctions. The current situation of constructing “digital sovereignty” of traditional states or of the EU is thus marked by the necessity of cooperation between the state power and those non-state entities which are falling under its analogue jurisdiction.
Application of 3D Roughness Parameters for Wear Intensity Calculations
Authors: Bulaha N. , Linins O. , Avisane A. 
Published: October 2021

Abstract
In this paper, calculations of 3D parameter Vm (material volume) of surfaces with irregular roughness and comparison with experimental data were performed, with further application of this parameter in calculations of wear intensity. First, using Mountains Map software for profilometric measurements, 3D roughness processing and determination of material volume Vm at specific relative levels γ were performed. The next step was an additional analysis of the distribution of surface ordinates using a theoretical and experimental Laplace function. The given check confirmed that for mostly surfaces with irregular roughness the ordinate distribution corresponds to the normal Gaussian distribution law, but in cases when the asymmetry of the ordinate distribution function goes outside the permissible limits (|∆Ssk|> 10%), errors> 10 % occur. On this basis, the mathematical formula of the material volume Vm was derived, and the obtained calculations were compared with the measured values. The results showed that the calculated values of the parameter Vm were very close to the experimental data (|∆Vm|<10 %), while at the relative level γ=+3, errors occurred that was related to the deviation from the normal distribution law. It was concluded that the given parameter could be used in the calculations of linear wear intensity, knowing the relative level γ.