bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of an in vitro thrombogenicity test system with cyclic olefin copolymer substrate for endothelial layer formation
Authors: Lau Skadi , Liu Yue , Maier Anna , Braune Steffen , Gossen Manfred , Neffe Axel T. , Lendlein Andreas 
Published: September 2021

AbstractIn vitro thrombogenicity test systems require co-cultivation of endothelial cells and platelets under blood flow-like conditions. Here, a commercially available perfusion system is explored using plasma-treated cyclic olefin copolymer (COC) as a substrate for the endothelial cell layer. COC was characterized prior to endothelialization and co-cultivation with platelets under static or flow conditions. COC exhibits a low roughness and a moderate hydrophilicity. Flow promoted endothelial cell growth and prevented platelet adherence. These findings show the suitability of COC as substrate and the importance of blood flow-like conditions for the assessment of the thrombogenic risk of drugs or cardiovascular implant materials.
Graphic abstract
Meshalkin National Medical Research Center
Authors: Bogachev-Prokofiev A. V. , Sharifulin R. M. , Astapov D. A. , Ovcharov M. A. , Ovchinnikova M. A. , Lavinyukov S. O. , Sapegin A. V. , Afanasyev A. V. , Zheleznev S. I. , Nazarov V. M. , Chernyavsky A. M. 
Published: September 2021

We present three cases of successful transatrial transcatheter valve-in-valve implantation in patients with bioprosthetic mitral valve dysfunction. Patients with a high surgical risk, with severe heart failure due to bioprosthetic mitral valve dysfunction, were implanted with transcatheter prostheses using the transatrial approach.Transesophageal echocardiography and fluoroscopy-guided transcatheter mitral prosthetic valve positioning was performed. With a cardiac pacing at 180 bpm, a transcatheter valve was implanted. The transcatheter valves functioned properly after surgery. The patients were discharged in satisfactory condition.
Echocardiographic characteristics of COVID-19 pneumonia survivors three months after hospital discharge
Authors: Yaroslavskaya I. , Krinochkin D. V. , Shirokov N. E. , Krinochkina I. R. , Gultyaeva E. P. , Garanina V. D. , Korovina I. O. , Mamarina A. V. , Osokina N. A. , Melnikov N. N. , Trifanova T. А. , Gorbatenko E. A. , Gorbatenko E. А. 
Published: September 2021

Coronavirus disease 2019 (COVID-19) is an infectious disease that affects almost all organs and systems. The main target is the respiratory system, but cardiovascular involvement is also common. Today, it is relevant to study the effect of complicated COVID-19 course on the patient’s cardiovascular system after hospital discharge — in particular, echocardiographic parameters.Aim. To study the echocardiographic parameters of patients with COVID-19 pneumonia 3 months after discharge from the hospital.Material and methods.The study included 106 patients with documented COVID-19 pneumonia. Patients underwent a comprehensive examination during hospitalization and 3 months ± 2 weeks after hospital discharge. The mean age of participants was 47±16 years (from 19 to 84 years), while 49% were women.Results.Three months after discharge, the average body mass index of the subjects was 28,2±5,7 kg/m2. Obesity was noted in 37,1%, cardiovascular diseases — in 52%. According to echocardiography, the prevalence of right ventricular (RV) dilatation was 2,9%, a decrease in tricuspid annular plane systolic excursion (TAPSE) — 9,5%, grade ≥2 tricuspid regurgitation — 1,9%, pulmonary hypertension (pulmonary artery systolic pressure >36 mm Hg) — 3,8%. The mean value of RV global longitudinal myocardial strain (GLMS RV) and global longitudinal myocardial strain (GLES RV) was 19,6±4,5 and 20,6±4,6, respectively. We found moderate correlations between GLMS RV and blood flow time through the left ventricular outflow tract (OT) (r=-0,436), through the mitral valve (r=-0,390; both p<0,0001) and through the RVOT (r=-0,348; р=0,004), with cardiac index (CI) (r=0,316; p=0,009), as well as between GLES RV and blood flow time through the LVOT (r=-0,411; p<0,0001) and RVOT (r=-0,300; p=0,005), and with CI (r=0,302; p=0,004). At the same time, the correlation of GLES RV with RV fractional area change (FAC) was weak (r=-0,283; p=0,007), while there was no correlation with the TAPSE. In addition, correlation of GLMS RV with these parameters were not defined.Conclusion.Three months after COVID-19 pneumonia, RV strain parameters were shown to have stronger relationships with time characteristics of flows in LVOT and RVOT, as well as with CI, than with such generally accepted characteristics of RV function as FAC and TAPSE.
COVID-19 pandemic prediction model based on machine learning in selected regions of the Russian Federation
Authors: Gavrilov D. V. , Abramov R. V. , Kirilkina А. V. , Ivshin А. А. , Novitskiy R. E. 
Published: September 2021

Background. Prediction of the new coronavirus infection (COVID-19) spread is important to take timely measures and initiate systemic preventive and anti-epidemic actions both at the regional and state levels to reduce morbidity and mortality.Objective: to develop a model for short-term forecasting of COVID-19 cases and deaths in the Russian Federation.Material and methods. The data for the model training were collected from the Stopcoronavirus.rf and Johns Hopkins University portals. It included 13 features to assess the infection dynamics and mortality, as well as the rate of morbidity and mortality in different countries and certain regions of the Russian Federation. The model was trained by the CatBoost gradient boosting method and retrained daily with updated data.Results. The forecast model of COVID-19 cases and deaths for the period of up to 14 days was created. The mean absolute percentage error (MAPE) estimate of the model’s accuracy ranged from 2.3% to 24% for 85 regions of the Russian Federation. The advantage of the CatBoost machine learning method over linear regression was shown using the example of the root mean square error (RMSE) value. The model showed less error for regions with a large population than for less populated ones.Conclusion. The model can be used not only to predict the pandemic of the novel coronavirus infection but also to control and assess the spread of diseases from the group of new infections at their emergence, peak incidence, and stabilization period.
Fault Displacement of the 2011 Mw 6.6 Fukushima-ken Hamadori Earthquake Based on a 3D Crustal Deformation Model Constructed Using Differential InSAR–Lidar
Authors: Aoyagi Yasuhira , Kageshima Mitsukazu , Onuma Takumi , Homma Shinichi , Mukoyama Sakae 
Published: September 2021

ABSTRACT
3D coseismic deformation detected by remote sensing yields essential information for estimating the geometry and slip distribution of the causative fault. However, it is often difficult to be obtained by a single observation method due to data acquisition constraints. This study constructs a 3D coseismic deformation model of the 2011 Fukushima-ken Hamadori earthquake by integrating Differential Interferometric Synthetic Aperture Radar (DInSAR), and differential light detection and ranging (Dlidar) analyses. Both horizontal and vertical movements observed are almost consistent with those of the theoretical dislocation model of normal faulting. The fault displacements measured within ±45 m of the rupture based on the 3D deformation model is also in good agreement with the possible maximum field displacements. Fault dips and lateral displacement components are also harmonious with the field survey measurements. Dlidar detects full 3D motion, whereas the DInSAR detects deformations too small for the light detection and ranging (lidar). Combining the two products is helpful to produce a more robust 3D displacement field than possible from the lidar alone.
A High-Order Finite-Difference Method on Staggered Curvilinear Grids for Seismic Wave Propagation Applications with Topography
Authors: O’Reilly Ossian , Yeh Te-Yang , Olsen Kim B. , Hu Zhifeng , Breuer Alex , Roten Daniel , Goulet Christine A. 
Published: September 2021

ABSTRACTWe developed a 3D elastic wave propagation solver that supports topography using staggered curvilinear grids. Our method achieves comparable accuracy to the classical fourth-order staggered grid velocity–stress finite-difference method on a Cartesian grid. We show that the method is provably stable using summation-by-parts operators and weakly imposed boundary conditions via penalty terms. The maximum stable timestep obeys a relationship that depends on the topography-induced grid stretching along the vertical axis. The solutions from the approach are in excellent agreement with verified results for a Gaussian-shaped hill and for a complex topographic model. Compared with a Cartesian grid, the curvilinear grid adds negligible memory requirements, but requires longer simulation times due to smaller timesteps for complex topography. The code shows 94% weak scaling efficiency up to 1014 graphic processing units.
Analisis Kegiatan Stimulasi Motorik Kasar untuk Anak Usia 5-6 Tahun pada Film Upin Ipin
Authors: Windawati Erlin , Kustiawan Usep , Astuti Wuri 
Published: September 2021

Abstract: Gross motor skills are the most important skills in growth and development in early childhood. There are many things that can exemplify gross motor activities to be applied to early childhood, one of which is the cartoon film Upin Ipin. This research is motivated by the large number of televisions that broadcast unfavorable content for children. It is different from the cartoon Upin Ipin which shows educational values, one of which is gross motoric activities. The purpose of this study was to analyze the gross motoric activities in the Upin Ipin film on the suitability of children aged 5-6 years based on Permendikbud No.137 of 2014. This study used a qualitative approach with the type of activity analysis. The instrument in this study besides the researcher as an instrument, the researcher used a data card. The results of this study indicate that the gross motor activities in the Upin Ipin film correspond to the stages of children aged 5-6 years.
Abstrak: Motorik kasar merupakan keterampilan yang paling utama dalam pertumbuhan dan perkembangan pada anak usia dini. Banyak hal yang dapat mencontohkan kegiatan-kegiatan motorik kasar untuk menstimulasi anak usia dini, salah satunya melalui film kartun Upin Ipin. Penelitian ini dilatarbelakangi banyaknya televisi yang menayangkan konten kurang baik untuk anak. Berbeda dengan film kartun Upin Ipin yang menayangkan nilai-nilai pendidikan, salah satunya kegiatan motorik kasar. Tujuan dari penelitian ini untuk menganalisis kegiatan motorik kasar yang ada pada film Upin Ipin terhadap kesesuaian anak usia 5-6 tahun berdasarkan Permendikbud No.137 Tahun 2014. Penelitian ini menggunakan pendekatan kualitatif dengan jenis analisis kegiatan. Instrumen pada penelitian ini selain peneliti sebagai instrumen, peneliti menggunakan kartu data. Hasil dari penelitian ini menunjukkan bahwa kegiatan motorik kasar yang ada pada film Upin Ipin sesuai dengan tahapan anak usia 5-6 Tahun.
Nadarajah-Haghighi Model for Survival Data With Long Term Survivors in the Presence of Right Censored Data
Authors: Usman Umar , Suleiman Shamsuddeen , Magaji Arkilla Bello , Aliyu Yakubu 
Published: September 2021

In this paper, a new long term survival model called Nadarajah-Haghighi model for survival data with long term survivors was proposed. The model is used in fitting data where the population of interest is a mixture of individuals that are susceptible to the event of interest and individuals that are not susceptible to the event of interest. The statistical properties of the proposed model including quantile function, moments, mean and variance were provided. Maximum likelihood estimation procedure was used to estimate the parameters of the model assuming right censoring. Furthermore, Bayesian method of estimation was also employed in estimating the parameters of the model assuming right censoring. Simulations study was performed in order to ascertain the performances of the MLE estimators. Random samples of different sample sizes were generated from the model with some arbitrary values for the parameters for 5%, 1:3% and 1:5% cure fraction values. Bias, standard error and mean square error were used as discrimination criteria. Additionally, we compared the performance of the proposed model with some competing models. The results of the applications indicates that the proposed model is more efficient than the models compared with. Finally, we fitted some models considering type of treatment as a covariate. It was observed that the covariate have effect on the shape parameter of the proposed model.
Evaluation of facemask associated acne/ “Maskne” among health care workers and non-health care workers of India during COVID-19 pandemic-A cross-sectional study
Authors: B Patel Krina , M. Nagani Savfeena , T. Patel Aanal , Bapat Nirav 
Published: September 2021

“MASK-NE”-Mask associated Acne, is a common form of acne during COVID-19 pandemic. It is type of acne mechanica seen when external factor occludes the skin, leads to irritation, inflammation and starts/aggravates all grades of acne.We conducted a cross-sectional study among 773 participants, using a Self-administered, aim oriented, questionnaire which includes demographic data, acne related history, type and duration of wearing mask & other mask related skin problems in COVID-19 pandemic during 15 October to 15December,2020.: Among 773 participants, age ranged 18-45 years with mean 30.69 (SD: 61.30) and M:F was 1:1.78. After starting of Pandemic, occurrence of new development of mask associated Acne/ Maskne was higher among Health Care Workers (HCW) (34.98%) as compared to non- Health Care Workers (non-HCWs) (17.36%). Moreover, more number of HCWs had aggravation of their pre-existing acne and/or development of new of acne during pandemic (81.2%) than non-HCWs (61%). Wearing N95 type of mask showed the highest aggravation (82%) of Maskne as compare to wearing Surgical mask (75.5%) and wearing cloth (cotton) mask (65.6%).Wearing a face mask for 4 to 8 hours/day and &#62;8 hours/day showed increase in the aggravation of Maskne as compared to wearing a facemask &#60;4 hrs/day.Though wearing face masks can be the best strategy against COVID-19 infection, HAZARD OF THIS SAFETY is not negligible especially in front-line workers-doctors, nurses, pharmacist, policemen, hospital staff who are at higher risk due to several factors including type of mask use, duration of mask use etc.
Efficacy and outcome of Microneedling (Dermaroller) in post-acne scars
Authors: C Lalitha , B Leelavathy , S Shwetha 
Published: September 2021

Acne vulgaris is a common dermatological disorder affecting teenagers and young adults with the consequence of scarring. As acne is considered as a normal occurrence and neglected or delayed treatment of severe acne lead to cosmetically disfiguring scarring leading to much psychological trauma to youngsters. Acne scarring can be atrophic or hypertrophic. There are multitude of treatment options for atrophic acne scars like dermabrasion, chemical peels and lasers. But these cosmetic procedures are have drawbacks like requiring fine skills and long downtime (dermabrasion), or expensive for most of the population(laser). Microneedling using dermaroller is an inexpensive safe therapeutic option for the Indian skin type with less complication. The aim of this study was to evaluate the efficacy of microneedling (dermaroller) in different types of atrophic acne scar and it’s complications.A descriptive study was performed using 30 patients with atrophic acne scar treated with microneedling for a period of two years. Details of duration, site, type and depth of acne scar along with skin types was recored. Patients were given dermaroller treatment for 4 session, each spaced at one month interval and results assessed at the end of each session and at end of six months. In this study, 30 patients with atrophic acne scars of grade 2 and 3 were treated with microneedling therapy and efficacy and complication of this therapy were evaluated. These patients had all three types of atrophic scars- rolling, ice- pick and boxcar, these 27 patients showed 50 % improvement in their scar score at the end of the study (6 months). Among above mentioned scar types, rolling and boxcar scar showed improvement by 47.42% and 65.40% respectively at the end of the study, whereas ice-pick scars showed no significant improvement. According to the modified acne scar scoring system, 55.6% of the patients had improvement in their scar scoring between 41 and 50% (good response) and 44.4 % had improvement of more than 50 % (very good response). All patients were satisfied with the outcome of the procedure.Microneedling is a safe, cost effective, innovative procedure in the treatment armamentarium of acne scars without major complications. This is found to be safe to use in Fitzpatrick type IV and V scars. However, further studies are necessary to validate these findings.
Subcutaneous fat necrosis of newborn - A rare case report of lobular panniculitis in a neonate
Authors: Akshay Samagani , Belliappa Pemmanda Raju , Leena Raveendra 
Published: September 2021

Subcutaneous fat necrosis of newborn is a rare cutaneous disorder affecting neonates. It usually presents as subcutaneous nodules or plaques, within the first few weeks of life, following an eventful delivery. It is characterized by hypercalcemia, which may present with lethargy, irritability, hypotonia and dehydration, mimicking sepsis. Histopathology is proven to be the gold standard in diagnosis with characteristic lobular panniculitis, mixed inflammatory cell infiltrate and radially arranged crystals. This needs to be differentiated from other causes of lobular panniculitis, as early diagnosis and treatment to prevent long‑term complications are advocated. Education of parents regarding the disease and danger signs of hypercalcemia and weekly monitoring of serum calcium is recommended. Treatment based on rehydration, dietary vitamin D and calcium restriction, Furosemide and prednisolone are considered. We have discussed a case of subcutaneous fat necrosis, in an 8-week-old male baby.Key Messages: Subcutaneous fat necrosis is an important differential in neonates presenting with palpable subcutaneous nodules, along with sclerema neonatorum. Severe complications like hypercalcemia should be detected early and managed aggressively to prevent morbidities and mortalities associated with it. Symptomatic management, use of calcium lowering drugs and regular monitoring of calcium levels are recommended.
Insight of medical students on online teaching during COVID-19 pandemic-A survey
Authors: Begum Vaseemunnisa , Sadiq Neeraj , Subhani Ghulam , Gulnaaz Asma , Mohsin Mohammed , Devi Nageswari 
Published: September 2021

: The Global disease (COVID-19 pandemic) has impacted our lives in various ways. Online teaching is the strange routine for studying platforms to continue with the process of educating students, Online classes have become a key component in the continuity of education.: 1. This study aims to rank the usefulness of online teaching compared to classroom conventional teaching 2. Socioeconomic parameters related to online teaching in a medical college: The study is a cross-sectional study done on medical students. A questionnaire was prepared listing the various ways in which they discern online teaching trying to cope up during the pandemic.: After the institutional Ethics committee clearance, online cross-sectional study was done on the medical students where from the 2 and 3 year. This online survey was done between 10May 2021- 10 June 2021, A total number of 211 students participated out of 250, after completion of 18 months of online classes. A Set of 15 self -designed questionnaire based on 5 point Likert scale was given to the students to rank the effectiveness through online class usefulness levels and satisfaction levels on various parameters. Students were also asked about the demographic factors. The data was analyzed using software SPSS software The study results shows that online classes is less helpful in five parameters and equally helpful in five parameters but was not at all superior to conventional methods, we can come to the interpretation that students think that classroom teaching cannot be replaced by online teaching. We can conclude that online studies can only be a supplement and cannot be an alternate for the established order of learning
A point prevalence survey study (PPS) of antimicrobial consumption in a tertiary care super-speciality hospital of West Bengal
Authors: Chakraverty Raja , Samanta Kalyan 
Published: September 2021

Antimicrobial resistance (AMR) is an emerging global health issue. Resistance occurs when bacteria, parasites, viruses or fungi are exposed to antimicrobials but not killed by them. The study was conducted to gather baseline information to assess the antimicrobial consumption practices across six departments in a tertiary care super speciality hospital of West Bengal. Modified version of a patient data collection form proposed by Global PPS was developed on Epi Info software version 7 (CDC). Data of all patients in ward at 08.00 am data were studied. The use of antimicrobials was categorized as empiric, prophylactic or lab based. This classification is not mentioned in the files, so a response from the doctor taking care of the patient was noted.A total of 85 patient related data was collected in the designated survey form. Total beds covered was 340 and the number of patients on antimicrobials was found to be low at 21.27 %. The patients surveyed were predominantly female (78.8 %). The mean number of antimicrobials per patient was found to be 1.62 (range of 1.4 to 2.2) Relatively low number of patients were found to be on 2 or more antimicrobials. Double gram negative and Double anaerobic coverage of AM used varied across departments covered.:Our point prevalence study was able to facilitate conducting of point prevalence survey in high patient volume tertiary care hospital with paper based medical record system and also depicted the baseline parameters of intervention for instituting future action and policy changes.
The Relationship between Time to Surgery (TTS) and Survival in Breast Cancer: A Systematic Review and Meta-Analysis
Authors: Su Yongcheng , Zheng Xiaogang , Ouyang Zhong 
Published: September 2021

Background: Curative operation is the practical and primary therapy for masses of breast cancers. In contrast, the correlation between the time interval from breast cancer diagnosis to curative surgery and survival is still uncertain.
Methods: An electronic literature search was conducted on PubMed/Medline and EMBASE (between Jan 2000 and Jan 2020). Primary endpoints were overall survival (OS) or Disease-Free Survival (DFS). The HR with 95% confidence intervals were calculated using a random-effects or fixed-effects model.
Results: The combined HR for OS was 1. 10 (95% CI 1. 08-1. 11; P=0. 000) by fixed-effects model, no statistically significant heterogeneity was found (P=1. 000; I2=0%), and this difference was statistically significant (Z=11. 99; P=0. 000).
Conclusion: This meta-analysis showed a significant adverse association between more prolonged time to surgery (TTS) and lower overall survival in patients with breast cancer. It is reasonable to minimize that interval between diagnosis and curative surgery.