bluuebunny/crossref_metadata_2025_split huggingface dataset:
Konteks Pembentuk Wacana Pacifism dalam Anime Hotaru no Haka karya Isao Takahata
Authors: Dana Pande Krisna , Ari Sulatri Ni Luh Putu , Anggraeny Renny 
Published: March 2021

The tittle of this research was “Forming Context of Pacifism Discourse in Hotaru no Haka anime by Isao Takahata”. The purpose of this research to find out the forming context of pacifism discourse in Hotaru no Haka anime by Isao Takahata. Data colletion method in this research was literature study method. The data were analyzed by using descriptive analysis method and informal method. The theory applied in this research was critical discourse analysis by Van Dijk (1988). The result in this research were 1) novelist and anime director are victims of war; 2) prohibition of war in article 9 of the Japanese Constitution and; 3) Japan signed the treaty of San Francisco.
Tazemetostat– A Drug review
Authors: Anju K Paul  , Hridya Jayamohanan  , Keechilat Pavithran  
Published: March 2021

Epithelioid sarcoma affects three in 10 million people, usually teenagers and young adults. Tumours grow under the skin of the extremities or they can affect the trunk, head, or neck. It grows slowly, but can infiltrate surrounding tissues, later on, it frequently metastasis to lymph nodes. For advanced case, doxorubicin-based chemotherapy regimen is recommended. In January 2020, FDA approved the first-in-class, small molecule enhancer of zeste homolog 2 (EZH2) inhibitor, tazemetostat (Tazverik) to treat adults and paediatric patients aged 16 years and older with locally advanced or metastatic epithelioid sarcoma not suitable for complete resection. The recommended dosage is 800 mg twice daily until disease progression or unacceptable toxicity. The first-in-human study of tazemetostat was a phase 1 open-label multi-centered dose-escalation study. Tazemetostat is having an oral bioavailability of approximately 33%. Apparent volume of distribution at steady-state (Vss/F) is 1230 L (46%) with 88% bound to human plasma proteins. Metabolism takes place via CYP3A. 15% and 79% of radioactivity is excreted through urine and feces respectively. ≥20% of the adverse reactions and above was fatigue, pain, constipation, nausea, anorexia and vomiting. This article summarizes the history, chemistry, physical properties, mechanism of action, indications, and drug–drug interactions of tazemetostat and we also discuss briefly the results of various clinical trials.
KEGUNAAN GINKGO BILOBA UNTUK PENGOBATAN PENYAKIT NEUROLOGIS
Authors: Sarifuddin Muftia Jauristika , Annisa Nurul 
Published: March 2021

Ginkgo Biloba adalah Salah satu tanaman yang tergolong sebagai fitofarmaka atau obat-obatan yang berasal dari tanaman ialah Ginkgo biloba Tanaman G.biloba (Gb) termasuk dalam familia Ginkgoceae. Di dalam ekstrak G.biloba terdapat antioksidan, antivirus, antiinflamasi, dan juga antikarsinogenik. Dan juga telah dinyatakan bahwa ekstrak G.biloba mempunyai efek yang baik terhadap fungsi SSP (sistem saraf pusat). Untuk mengetahui manfaat G.biloba dalam penanganan gangguan neurologis. Dibuat dengan menggunakan metode studi pustaka untuk mengumpulkan referensi yang valid mengenai tanaman Ginkgo Biloba yang dapat digunakan sebagai penanganan gangguan Neurologi. Hasil literature review berdasarkan studi pustaka yang dilakukan menunujukkan bahwa tanaman Ginkgo Biloba yang dapat digunakan sebagai penanganan penyakit neuorologis dengan kandungan dan efek terhadap tubuh. Dalam literature review ini didapatkan tanaman Ginkgo Biloba yang dapat digunakan sebagai penanganan gangguan neurologis
Effectiveness of Resuscitation Device when Intubating Suspected COVID-19 Patient at Emergency and Trauma Department
Authors: Khusairi Zainul Ikhwan Ahmad 
Published: March 2021

Introduction: The rapid spread of COVID-19 had expanded into a pandemic, and thousands of medical staff had been infected worldwide. Thus, the access to personal protective equipment (PPE) for health workers had become a key concern. PPE was essential in providing a physical barrier between microorganism and health care providers. In the case of cardiac arrest, the use of a resuscitation device as PPE had provoked various reactions and complaints from physicians.Objective: To determine the effectiveness of the use of an intubation box and ergonomic screening booth as a device during intubation procedures on positive COVID-19 patients in the Department of Emergency and Trauma at Taiping Public Hospital.Methods: The study was designed as a single-blind, prospective, randomized study and was approved by the committee at study location setting. Physicians selected had been given three days of training related to the use of the device as one of the PPE, before being used on patients. The procedure was carried out on three patients with unclear history of COVID-19who required intubation. The time given for each intubation procedure was 5 to10 seconds with a maximum of three attempts for each patient.Results: The results found that all three intubation procedures required longer time whereby all procedures took two attempts for each patient. The process of intubation took more than 30 seconds for the first attempt and failed but all cases took about 5 to 10 seconds for second attempts.Conclusion: This has proven that the use of an intubation box and ergonomic screening booth as a device during intubation procedures was not effective. It is suggested that this device should not be continued by paramedics and a proper management plan is needed to provide appropriate and suitable device innovations.International Journal of Human and Health Sciences Supplementary Issue: 2021 Page: S14
The Use of Magnetic Resonance Imaging in Managing Intra-Abdominal Pregnancy
Authors: Khusairi Zainul Ikhwan Ahmad , Sze Tan Ling 
Published: March 2021

Introduction: Most pregnant women will experience a normal pregnancy process. However, there are some complications that may occur during pregnancy, including intra-abdominal pregnancy. Intra-abdominal pregnancy, or pregnancy outside of the uterus, are commonly reported besides abortion, pregnancy-induced hypertension (PIH) and gestational diabetes mellitus (GDM). Thesecomplications are believed to be the main cause of maternal and perinatal death. Therefore, the use of appropriate diagnostic imaging inthe management of obstetric cases should be focused.Objective: This case study intended to evaluate the use of magnetic resonance imaging (MRI) in managing intra-abdominal pregnancy.Case Presentation: The study focused on one case with intra-abdominal pregnancy which continued into the second trimester. A 30-year-old woman, G2 P0+1 at 12-13 weeks’ gestation was presented to a public hospital complaining of recurrent epigastric pain with no history of vaginal bleeding. An MRI was performed and the mother was identified as having an intraabdominal pregnancy. Urgent laparotomy was done. Intraoperative finding noted hematoperitoneum with active bleeding seen from the placenta that adhered to the omentum. Partial omentectomy was done. The foetus in about 14 week’s gestation was seen and removed. Case studies have proven that the option to perform an MRI on a suspected intra-abdominal pregnancy can help provide information to establish an accurate diagnosis and appropriate patient care management.Conclusion: The use of MRI is highly recommended for all cases that are expected to experience intra-abdominal pregnancy as it will save the patient as well as avoiding obstetric complications.International Journal of Human and Health Sciences Supplementary Issue: 2021 Page: S16
Healthcare Practitioner’s Views on the Teddy Bear Hospital (TBH) by IMACATS in Malaysia
Authors: Rashid Aneesa Abdul , Theng Cheong Ai , Shanmugam Ranita Hisham , Shamsuddin Nurainul Hana , Roslan Dalila 
Published: March 2021

Introduction: This is a part of a bigger study entitled “Exploring the Views of Healthcare Practitioners on the Teddy Bear Hospital (TBH) as a Personal Safety Module Towards Prevention of Child Sexual Abuse (CSA): A Qualitative Study”. TBH is a make-believe-play hospital utilising soft toys to demonstrate a pretend clinical setting with the aim to educate children on health issues. Studies has shown its effectiveness and reducing anxiety towards the hospital setting and increasing health-related knowledge. IMAM Children’s and Teen Super teen (IMACATS) is one of the non-governmental organisations (NGO) which has adopted this concept to tailor to the local community. The volunteers are healthcare practitioners who are engaged with children in their practice.Objective: To explore the views of healthcare professional towards TBH by IMACATS in Malaysia.Methods: In-depth qualitative audio recorded interviews were conducted with a purposive sample of 18 healthcare professionals. The data obtained were transcribed and analysed thematically.Results: Three themes were derived from the interviews: i) Awareness of the TBH concept. Seven participants have volunteered in TBH previously. However, there was a speculation that many doctors are still unknowing of this concept. ii) Benefits of TBH. This includes reducing children’s anxiety, changing children’s presumption on healthcare, increasing children’s health knowledge and encouraging healthy behaviour and bridging the gap between the public and healthcare. iii) Suggestion of Module for future TBH: (a) More school-based programmes should be organised in addition to hospital and community based; (b) Ministry of Health (MOH) should encourage children health screening using this concept; (c) A module for hospitalised children should be conducted.Conclusion: Participants interviewed suggested for TBH to be organised in a wider scale as it is an approachable concept for educating children. There are many ways in which it can benefit this community.International Journal of Human and Health Sciences Supplementary Issue: 2021 Page: S18
The Impact of Proper PPE Protocol in A Highly Community Spread of Infectious COVID-19 in Semporna
Authors: Abidin Muhammad Farid Bin Zainal , Zainan Nur Farhana Binti , Mamat Mafeitzeral Bin , Pubalan Sivasankar , Yunus Mohd Syahfadzreen Bin 
Published: March 2021

Introduction: The district of Semporna, Sabah was majorly hit by the third wave surge of COVID-19 in September 2020. At the peak of the crisis, services in Semporna Hospital were paralyzed with 40 healthcare workers (HCW) found to be COVID-19 positive; contributing to 14% of the total manpower.Objectives: Due to the immediate crisis, the main priority was to control the spread of COVID- 19 amongst the Semporna Hospital HCWs. This was important to curb direct infection from handling suspected patients seeking treatment in Semporna Hospital. Based on the hospital capabilities and resources, a comprehensive modified protocol was needed to control the situation.Methods: Semporna Hospital pandemic emergency task force was established with the presence of multi department and specialties. Multiple issues were raised and attended to, especially; issue of preparedness, low PPE stock and Emergency Department infrastructure.Results: The number of Semporna Hospital HCWs infected with COVID-19 was minimal after the initial disaster. Emergency Department infrastructure was improvised, workflow processes modified, HCW protection education prioritized and complete PPE sets were stocked up. All these efforts were under the strict supervision of the infectious control unit. The presence of multiple units of Powered Air-Purifying Respirator (PAPR) completed our adherence to the Ministry of Health (MOH) guidelines in managing the highly infectious level 4 patients for aerosolized generating procedures (AGP).Conclusion: This achievement can be used as a preparedness reference for other non-specialist district hospitals in Malaysia.International Journal of Human and Health Sciences Supplementary Issue: 2021 Page: S21
EPIDEMIOLOGY, PROGNOSIS AND RISK FACTORS FOR DEVELOPMENT OF ONCOLOGICAL DISEASES AS EARLY DIAGNOSTIC OF DENTAL PROBLEMS IN THE CHILDREN
Authors: Hryhorenko Luibov , Samoilenko A. A.  , Romaniuta I. A.  
Published: March 2021

Introduction. In the world trends in incidence and death rates for all cancers combined and for the leading cancer types by sex, racial/ethnic group, and age were estimated by analysis and characterized by the average annual percent change during recent 5 years. Aim of research: to determine epidemiology of oncological diseases in the children population of rural clusters due to the chemical contamination of drinking water sources. Materials and methods. Analysis of water-related health indicators in the children population. Drinking water quality monitoring included studies of chemical and salt composition of water from centralized (38260 studies) and decentralized (24586 studies) water supply systems carried out in rural clusters of Dnipropetrovsk region. Results. As a result of discriminant analysis, a plausible model probable development of cancer among children population in rural clusters of Dnipropetrovsk region, which consumed drinking water from decentralized drinking water sources was obtained. Conclusions. According to the correlation analysis was determined that oncological morbidity among children population responded quickly to the changes in salt and chemical composition of water from centralized and decentralized drinking water systems. In 3, 4, 5, 6 clusters of Dnipropetrovsk region high levels of morbidity this class of diseases (r=0,763, p=0,077) were observed in children who consume wells water with high nitrate content (at the limit of MPC 45 mg / dm3). It was established that prognostic capacity for a model of development cancer in children under 14 years is 34%. During 2014–2019 years tendency of negative growth of tumors in the children population of Dnipropetrovsk region in all clusters was established: 1 (-20.9 %), 2 (-37.5 %), 3 (-31.1 %), 4 (-33.8 %), 5 (-22.3 %), 6 (-29.2 %).
Characteristics of non-Hodgkin lymphoma patients in Otorhinolaryngology-HNS Department Zainoel Abidin General Hospital Banda Aceh
Authors: Fadhlia Fadhlia , Kurnia Benny , Setiani Lily , Karnita Yerni , Juniar Juniar , Berliananda Iip 
Published: March 2021

Background: Non-Hodgkin’s lymphoma (NHL) is a primary malignancy in the lymphatic system and extranodal lymphoid tissue originating from B lymphocyte cells, T lymphocytes or natural killer (NK) cells. The incidence of NHL continues to increase with various characteristics. Objective: To find out the characteristics of NHL sufferers undergoing treatment in Otorhinolaryngology Head and Neck Surgery Department of dr. Zainoel Abidin Regional General Hospital (RSUDZA), Banda Aceh from January 2015 to December 2018. Method: This was an observational descriptive study conducted at Banda Aceh RSUDZA using retrospective secondary data collection from medical records that met the inclusion criteria, in total sampling method. Result: Found 32 research subjects, dominantly male (20), the highest age range was 56-65 years (10). The main complaints were neck lumps (10) and oropharynx lumps (11). The most common NHL was from B lymphocyte cells (6). The chemotherapy regimens used are cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). The most frequent side effects are anemia, hypoalbuminemia, and leukopenia. Conclusion: The results showed that NHL was most common in men with an increased incidence in the fifth decade. Neck lumps are the most common complaint. The chemotherapy regimen used is CHOP and R-CHOP.Keywords : Non-Hodgkin’s Lymphoma, chemotherapy ABSTRAK Latar belakang: Limfoma Non-Hodgkin (LNH) adalah keganasan primer pada sistem limfatik dan jaringan limfoid ekstranodal yang berasal dari sel limfosit B, limfosit T atau sel natural killer (NK). Kejadian LNH terus meningkat dengan berbagai karakteristik. Tujuan: Melihat karakteristik penderita LNH yang menjalani pengobatan di Departemen THT-KL RSUD dr. Zainoel Abidin (RSUDZA), Banda Aceh pada periode Januari 2015 sampai Desember 2018. Metode: Penelitian deskriptif observasional dengan pengambilan data sekunder secara retrospektif dari rekam medis yang memenuhi kriteria inklusi, dengan metode total sampling. Hasil: Didapatkan total subjek penelitian 32 orang, dominan pada lakilaki (20), rentang usia tertinggi antara 56-65 tahun (10). Keluhan utama terbanyak adalah benjolan di leher (10) dan benjolan orofaring (11). LNH yang berasal dari sel limfosit B paling banyak dijumpai (6). Regimen kemoterapi yang digunakan adalah cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) dan rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Efek samping paling sering adalah anemia, hipoalbuminemia dan leukopenia. Kesimpulan: Hasil penelitian menunjukkan LNH paling sering pada laki-laki dengan angka kejadian meningkat pada dekade kelima. Keluhan yang paling sering adalah benjolan di leher. Regimen kemoterapi yang digunakan adalah CHOP dan R-CHOP.
The role of Programmed Death-Ligand 1 expression in nasopharyngeal carcinoma
Authors: Karsa Nadya Dwi 
Published: March 2021

ABSTRACTBackground: Nasopharyngeal carcinoma (NPC) is a malignant tumor that arises from the epithelial cell that cover surface of the nasopharynx, which has the highest incidence of all types of head and neck cancer. Cell-mediated immunity plays an important role in the growth and development of NPC. The expressions of Programmed Death-Ligand 1 (PD-L1) of NPC is still being debated and researched. Objective: To find out and understand the role of PD-L1 expression in NPC. Literature review: PD-L1 is a ligand from Programmed Death-1 (PD-1) receptors that could be expressed by cancer cells. When the PD-1/PD-L1 pathway is active, it promotes survival of cancer cells via anti apoptotic signals and inhibits the activation of signaling pathways, which are critical for survival of T cells. Conclusion: Various studies had found an increase of the PD-L1 expression in NPC cancer cells. PD-L1 is also a potentially important tumor immunotherapy target and can be a significant prognostic factor in NPC. ABSTRAKLatar belakang: Karsinoma nasofaring (KNF) merupakan suatu tumor ganas epitelial nasofaring yang mempunyai insiden tertinggi di antara kanker kepala dan leher. Imunitas selular mempunyai peran penting terhadap pertumbuhan dan perkembangan KNF. Ekspresi Programmed Death-Ligand 1 (PD-L1) pada KNF masih diperdebatkan dan diteliti. Tujuan: Mengetahui dan memahami peran PD-L1 terhadap kejadian KNF. Tinjauan Pustaka: PD-L1 merupakan ligan dari reseptor Programmed Death-1 (PD-1) yang dapat diekpresikan oleh sel kanker. Jalur PD-1 / PD-L1 yang teraktivasi akan melindungi sel kanker melalui sinyal anti apoptosis dan menghambat aktivasi jalur-jalur pengiriman sinyal lain yang sangat penting untuk kelangsungan hidup sel T. Kesimpulan: Berbagai penelitian menemukan adanya peningkatan ekspresi PD-L1 pada sel kanker KNF. PD-L1 menjadi suatu target imunoterapi yang sangat penting dalam meningkatkan respon imun terhadap sel kanker dan dapat dijadikan suatu faktor prognosis pada KNF.
Effects of poultry litter compost and chemical fertilizers on growth and yield of field grown sunflower (Helianthus annus L.)
Authors: Alauddin M , Mohsin GM , Ali AHM Zulfiquar , Rahman MK 
Published: March 2021

A field experiment was carried out in the research farm of Charfasson Govt. College, Bhola during Rabi season in 2016-2017 to evaluate the effects of poultry litter (PL) compost and NPK fertilizers on growth and yield of sunflower cv. BARI-2 (Keroni-2). Sixteen treatments were used with three replications each. Treatments were T1 : Control (-PL and –NPK), T2 : 1.5 ton PL/ha, T3 : 3.0 ton PL/ha, T4 : 4.5 ton PL/ha, T5 : N40P30K50 kg/ha, T6 : N80P60K100 kg/ha, T7 : N120P90K150 kg/ha, T8 : 1.5ton PL/ha + N40P30K50 kg/ha, T9 : 1.5 ton PL/ha + N80P60K100 kg/ha, T10 : 1.5 ton PL/ha + N120P90K150 kg/ha, T11 : 3.0 ton PL/ha +N40P30K50 kg/ha, T12 : 3.0 ton PL/ha + N80P60K100 kg/ha, T13 : 3.0 ton PL/ha + N120P90K150 kg/ha, T14 : 4.5 ton PL/ha + N40P30K50 kg/ha, T15 : 4.5 ton PL/ha + N80P60K100 kg/ha and T16 : 4.5 ton PL/ha + N120P90K150 kg/ha. Plant height (204.3 cm), number of leaf (44.8/plant), leaf area (376.4 cm2/plant), leaf area index (13.61), dry weight of stem (61.57 g/plant), root (12.66 g/plant), leaf (21.47 g/plant), petiole (8.7 g/plant), total dry matter production (134.0 g/plant) were found highest in T16 treatment. On the contrary, dry weight of inflorescence (32.6 g/plant), dry weight of seed (44.4 g/plant) and number of seeds (663/plant) were found highest in T13 and T14 treatments, respectively. Higher dry weight of 100 seeds (7.4 g) and diameter of inflorescence (54 cm) were also found in T13 treatment. Although highest value was found in T16 treatment, but T16 and T13 were not significantly (p > 0.05) different, it can be treated as best (T13) for future trial. The overall findings of this study indicated that organic fertilizer (poultry litter) in combination with inorganic fertilizers may be a good indicator to achieve better agronomic and yield parameters of sunflower plants under southern coastal edaphic conditions of Bangladesh.
Dhaka Univ. J. Biol. Sci. 30(1): 49-57, 2021 (January)
Assessment of soil carbon storage and nutrient contents in some wetlands soils of the northeastern region of Bangladesh
Authors: Rahman Arafat , Islam MS , Murshed Humyra B , Uddin MJ , Mohiuddin ASM , Rahman Muhaiminur 
Published: March 2021

An investigation was carried out in four designated wetlands to assess soil organic carbon (SOC) storage and evaluate soil nutrients of the northeastern Sylhet basin of Bangladesh. SOC storage was the highest in the Nikli wetland (4.1 Tg), followed by Hakaluki (4.0 Tg), Hail (2.8 Tg) and Balai wetland soils (2.6 Tg) at 100 cm depths. It is found that the total soil C storage across the medium low land (MLL) and low land (LL) sites covering the four wetlands of the Sylhet basin is about 13.5Tg. C storage across the MLL and LL sites at 100 cm depths was estimated about 5.1Tg and 8.4Tg respectively. It is found that SOC storage was higher in the low land sites in contrast to medium low land sites. The soil property varies depending on land types, soil depths and spatial distributions. Among the investigated wetland soils, Hakaluki wetland stored higher amount of SOC in the deeper soil layers whereas an inverse relationship between soil depth and SOC storage was noted for rest of the wetlands. It is apprehended that SOC storage thus gradually lessening in greater magnitude due to climate change and other anthropogenic reasons. An integrated management approach should be developed to restore the SOC sink.
Dhaka Univ. J. Biol. Sci. 30(1): 115-124, 2021 (January)