bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new cracking resistance index based on fracture mechanics for high strength sheet metal ranking
Authors: Frómeta D. , Parareda S. , Lara A. , Grifé L. , Tarhouni I. , Casellas D. 
Published: June 2021

Abstract
Driven by current safety and weight reduction policies in the automotive sector, the development of new high strength sheet metal products has experienced unprecedented growth in the last years. With the emergence of these high strength materials, new challenges related to their limited ductility and higher cracking susceptibility have also raised. Accordingly, the development of new fracture criteria accounting for the material’s cracking resistance has become unavoidable. In this work, a new cracking resistance index (CRI) based on fracture mechanics is proposed to classify the crack propagation resistance (i.e. the fracture toughness) of high strength metal sheets. The index is based on the fracture energy obtained from tensile tests with sharp-notched specimens. The procedure is very fast and simple, comparable to a conventional tensile test, and it may be used as routine testing for quality control and material selection. The CRI is investigated for several advanced high strength steel (AHSS) sheets of 0.8-1.6 mm thickness with tensile strengths between 800 and 1800 MPa. The results show that the proposed index is suitable to rank high strength steel sheets according to their crack propagation resistance and it can be correlated to the material’s crashworthiness and edge cracking resistance.
Simulation based approach for light weighting of Connecting rod by tube hydro forming process
Authors: Pandey A K , Walunj B S , Date P P 
Published: June 2021

Abstract
Several attempts have been made to reduce the weight of vehicles in order to increase overall fuel efficiency. Most attempts are focused on the light-weighting of BIW parts. However, very few attempts have been reported on the light-weighting of engine and transmission components. The present study aims at another method of light-weighting and manufacture of the light-weight connecting rod. To reduce the weight of connecting rod a new innovative manufacturing route using tube hydroforming has been proposed. A seamless tube is used as the raw material, which is deformed to its final shape by tube hydroforming. An innovative set of design features were needed for manufacturability using a tube as a raw material. Critical parameters of the solid connecting rod, such as diameters of holes at the big end as well as the small end, and the centre to centre distance, have been maintained equal to the reference solid forged connecting rod. Forming limit diagram has been used to predict the forming safety of the material during the forming process.
Study on new hot stamping tool with low cost and high cooling efficiency
Authors: Peng S , Zhou J , Qian S , Zhang M , Liu J , Meng Y 
Published: June 2021

Abstract
A new manufacturing method of hot stamping tool with CCC is proposed in this study. A pair of optimal hot stamping tool should have long service life, low manufacturing cost and good cooling performance simultaneously. The CuCrZr alloy and Fe-based alloy is selected as interlayer layer (IL) and surface layer (SL) respectively. The maximum stress of new tool was less than the yield strength of the corresponding welding materials, which demonstrated that new tool manufactured by surfacing technology could satisfy the strength requirement and deserve further research.
Effect of grain boundary engineering on corrosion behavior of nickel-based alloy 825 in sulfur environment
Authors: Fan Zhou , Zhang Yidong , Hu Xiaogang , Yang Dawei , Wang Yang , Liu Jianyi 
Published: June 2021

Abstract
Grain boundary engineering (GBE) by appropriate deformation and heat treatment processes was applied to nickel-based alloy 825 due to its excellent corrosion resistance. The microstructure of nickel-based alloy was analyzed by electron backscatter diffraction (EBSD) and the effect of GBE on the corrosion resistance in high sulfur-containing environments was studied by electrochemical method. The results show that the ratio of low Σvalue coincidence site lattice (CSL) grain boundary is obviously improved from 47.1% to 65.5%. The special angle grain boundaries Σ3, Σ9, Σ27 and so on are randomly distributed on the network of the large angle grain boundaries, which destroy the connectivity of the original grain boundary network, and effectively block the corrosion cracking of the material along them. The corrosion resistance of nickel-based alloy 825 in high sulfur environments is enhanced verified by polarization curve and scanning electrochemical microscope, providing references for corrosion protection during the exploitation of high sulfur gas reservoirs.
The nurse-coordinated cardiac care bridge transitional care programme: a randomised clinical trial
Authors: Jepma Patricia , Verweij Lotte , Buurman Bianca M , Terbraak Michel S , Daliri Sara , Latour Corine H M , ter Riet Gerben , Karapinar - Çarkit Fatma , Dekker Jill , Klunder Jose L , Liem Su-San , Moons Arno H M , Peters Ron J G , Scholte op Reimer Wilma J M 
Published: June 2021

Abstract

Background
after hospitalisation for cardiac disease, older patients are at high risk of readmission and death.

Objective
the cardiac care bridge (CCB) transitional care programme evaluated the impact of combining case management, disease management and home-based cardiac rehabilitation (CR) on hospital readmission and mortality.

Design
single-blind, randomised clinical trial.

Setting
the trial was conducted in six hospitals in the Netherlands between June 2017 and March 2020. Community-based nurses and physical therapists continued care post-discharge.

Subjects
cardiac patients ≥ 70 years were eligible if they were at high risk of functional loss or if they had had an unplanned hospital admission in the previous 6 months.

Methods
the intervention group received a comprehensive geriatric assessment-based integrated care plan, a face-to-face handover with the community nurse before discharge and follow-up home visits. The community nurse collaborated with a pharmacist and participants received home-based CR from a physical therapist. The primary composite outcome was first all-cause unplanned readmission or mortality at 6 months.

Results
in total, 306 participants were included. Mean age was 82.4 (standard deviation 6.3), 58% had heart failure and 92% were acutely hospitalised. 67% of the intervention key-elements were delivered. The composite outcome incidence was 54.2% (83/153) in the intervention group and 47.7% (73/153) in the control group (risk differences 6.5% [95% confidence intervals, CI −4.7 to 18%], risk ratios 1.14 [95% CI 0.91–1.42], P = 0.253). The study was discontinued prematurely due to implementation activities in usual care.

Conclusion
in high-risk older cardiac patients, the CCB programme did not reduce hospital readmission or mortality within 6 months.

Trial registration
Netherlands Trial Register 6,316, https://www.trialregister.nl/trial/6169
Leaf size estimation based on leaf length, width and shape
Authors: Schrader Julian , Shi Peijian , Royer Dana L , Peppe Daniel J , Gallagher Rachael V , Li Yirong , Wang Rong , Wright Ian J 
Published: June 2021

AbstractBackground and AimsLeaf size has considerable ecological relevance, making it desirable to obtain leaf size estimations for as many species worldwide as possible. Current global databases, such as TRY, contain leaf size data for ~30 000 species, which is only ~8% of known species worldwide. Yet, taxonomic descriptions exist for the large majority of the remainder. Here we propose a simple method to exploit information on leaf length, width and shape from species descriptions to robustly estimate leaf areas, thus closing this considerable knowledge gap for this important plant functional trait.MethodsUsing a global dataset of all major leaf shapes measured on 3125 leaves from 780 taxa, we quantified scaling functions that estimate leaf size as a product of leaf length, width and a leaf shape-specific correction factor. We validated our method by comparing leaf size estimates with those obtained from image recognition software and compared our approach with the widely used correction factor of 2/3.Key ResultsCorrection factors ranged from 0.39 for highly dissected, lobed leaves to 0.79 for oblate leaves. Leaf size estimation using leaf shape-specific correction factors was more accurate and precise than estimates obtained from the correction factor of 2/3.ConclusionOur method presents a tractable solution to accurately estimate leaf size when only information on leaf length, width and shape is available or when labour and time constraints prevent usage of image recognition software. We see promise in applying our method to data from species descriptions (including from fossils), databases, field work and on herbarium vouchers, especially when non-destructive in situ measurements are needed.
Effect of different heating conditions on odor of yellowtail Seriola quinqueradiata muscles
Authors: Hamakawa Yumi , Mukojima Kaori , Uchiyama Maki , Okada Shoko , Mabuchi Ryota , Furuta Ayumi , Tanimoto Shota 
Published: June 2021

ABSTRACT
The effects of different heating conditions set to prevent food poisoning on the volatile components, lipid oxidation, and odor of yellowtail, Seriola quinqueradiata, were investigated. The heating conditions did not affect the lipid oxidation, fatty acid composition, and volatile compounds of each part of the flesh. High-temperature/short-time (90 °C for 6 min) heating led to significantly higher trimethylamine (TMA) contents in all muscle parts and higher odor intensity of TMA in dark muscle (DM) compared to those of lower temperature heating. Sensory evaluation showed that the odor intensities of all muscle parts heated at high-temperature/short-time were stronger than those at low-temperature/long-time (63 °C for 30 min). All DM samples had less odor palatability than the other flesh parts. Therefore, DM may have contributed to the unfavorable odor of steamed yellowtail meat and high-temperature/short-time heating may have enhanced the odor of all flesh parts compared with those subjected to low-temperature/long-time.
MutaFrame—an interpretative visualization framework for deleteriousness prediction of missense variants in the human exome
Authors: Ancien François , Pucci Fabrizio , Vranken Wim , Rooman Marianne 
Published: June 2021

Abstract

Motivation
High-throughput experiments are generating ever increasing amounts of various -omics data, so shedding new light on the link between human disorders, their genetic causes and the related impact on protein behavior and structure. While numerous bioinformatics tools now exist that predict which variants in the human exome cause diseases, few tools predict the reasons why they might do so. Yet, understanding the impact of variants at the molecular level is a prerequisite for the rational development of targeted drugs or personalized therapies.

Results
We present the updated MutaFrame webserver, which aims to meet this need. It offers two deleteriousness prediction softwares, DEOGEN2 and SNPMuSiC, and is designed for bioinformaticians and medical researchers who want to gain insights into the origins of monogenic diseases. It contains information at two levels for each human protein: its amino acid sequence and its three-dimensional structure; we used the experimental structures whenever available, and modeled structures otherwise. MutaFrame also includes higher-level information, such as protein essentiality and protein–protein interactions. It has a user-friendly interface for the interpretation of results and a convenient visualization system for protein structures, in which the variant positions introduced by the user and other structural information are shown. In this way, MutaFrame aids our understanding of the pathogenic processes caused by single-site mutations and their molecular and contextual interpretation.

Availability and implementation
Mutaframe webserver at http://mutaframe.com/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Clinician perspectives and sense of efficacy about the implementation of recovery-oriented practice in mental health
Authors: Chisholm Janice , Petrakis Melissa 
Published: June 2021

Abstract
Recovery-oriented practice (ROP) is being steadily adopted worldwide. The current research examined the perspectives of clinicians about ROP pre-implementation at a clinical mental health service. The method was a survey consisting of fourteen questions regarding implementation of ROP and clinicians reported self-efficacy about work within a ROP framework. The research design was mixed methods couched within a narrative approach. It was exploratory and social constructivist in nature. This article explores quantitative data. Participants were 203 mental health clinicians from multidisciplinary backgrounds—including social work, nursing, occupational therapy, psychiatry, psychology, other medical and other allied health. There were 142 females, 46 males; 15 did not specify their sex. Results showed that clinicians perceived their practice was recovery-oriented 83.6 per cent of the time. Overall, 81 per cent chose the most recovery-oriented statement prior to formal training in ROP. This study concludes that clinicians are committed to the implementation of ROP. They do not believe ROP is easy to implement; however, they do believe it can be successfully implemented in the clinical treatment setting. With the support of stakeholders, these findings may be used to aid the ongoing implementation of ROP into the study service, and add to social work literature.
Spinal cord compression is associated with brain plasticity in degenerative cervical myelopathy
Authors: Cronin Alicia E , Detombe Sarah A , Duggal Camille A , Duggal Neil , Bartha Robert 
Published: June 2021

Abstract
The impact of spinal cord compression severity on brain plasticity and prognostic determinates is not yet fully understood. We investigated the association between the severity of spinal cord compression in patients with degenerative cervical myelopathy, a progressive disease of the spine, and functional plasticity in the motor cortex and subcortical areas using functional magnetic resonance imaging. A 3.0 T MRI scanner was used to acquire functional images of the brain in 23 degenerative cervical myelopathy patients. Patients were instructed to perform a structured finger-tapping task to activate the motor cortex to assess the extent of cortical activation. T2-weighted images of the brain and spine were also acquired to quantify the severity of spinal cord compression. The observed blood oxygen level-dependent signal increase in the contralateral primary motor cortex was associated with spinal cord compression severity when patients tapped with their left hand (r = 0.49, P = 0.02) and right hand (r = 0.56, P = 0.005). The volume of activation in the contralateral primary motor cortex also increased with spinal cord compression severity when patients tapped with their left hand (r = 0.55, P = 0.006) and right hand (r = 0.45, P = 0.03). The subcortical areas (cerebellum, putamen, caudate and thalamus) also demonstrated a significant relationship with compression severity. It was concluded that degenerative cervical myelopathy patients with severe spinal cord compression recruit larger regions of the motor cortex to perform finger-tapping tasks, which suggests that this adaptation is a compensatory response to neurological injury and tissue damage in the spinal cord.
Cerebellar Continuous Theta Burst Stimulation Facilitates Auditory–Vocal Integration in Spinocerebellar Ataxia
Authors: Lin Qing , Chang Yichen , Liu Peng , Jones Jeffery A , Chen Xi , Peng Danhua , Chen Mingyuan , Wu Chao , Liu Hanjun 
Published: June 2021

Abstract
Clinical studies have shown the efficacy of transcranial magnetic stimulation in treating movement disorders in patients with spinocerebellar ataxia (SCA). However, whether similar effects occur for their speech motor disorders remains largely unknown. The present event-related potential study investigated whether and how abnormalities in auditory–vocal integration associated with SCA can be modulated by neuronavigated continuous theta burst stimulation (c-TBS) over the right cerebellum. After receiving active or sham cerebellar c-TBS, 19 patients with SCA were instructed to produce sustained vowels while hearing their voice unexpectedly pitch-shifted by ±200 cents. Behaviorally, active cerebellar c-TBS led to smaller magnitudes of vocal compensations for pitch perturbations than sham stimulation. Parallel modulatory effects were also observed at the cortical level, as reflected by increased P1 and P2 responses but decreased N1 responses elicited by active cerebellar c-TBS. Moreover, smaller magnitudes of vocal compensations were predicted by larger amplitudes of cortical P1 and P2 responses. These findings provide the first neurobehavioral evidence that c-TBS over the right cerebellum produces modulatory effects on abnormal auditory–motor integration for vocal pitch regulation in patients with SCA, offering a starting point for the treatment of speech motor disorders associated with SCA with cerebellar c-TBS.
The Effects of Malaria in Pregnancy on Neurocognitive Development in Children at 1 and 6 Years of Age in Benin: A Prospective Mother–Child Cohort
Authors: Garrison Amanda , Boivin Michael J , Fiévet Nadine , Zoumenou Roméo , Alao Jules M , Massougbodji Achille , Cot Michel , Bodeau-Livinec Florence 
Published: June 2021

Abstract

Background
Malaria in pregnancy (MiP) contributes significantly to infant mortality rates in sub-Saharan Africa and has consequences on survivors, such as preterm birth and low birth weight. However, its impact on long-term neurocognitive development in children remains unknown.

Methods
Our prospective cohort included pregnant women and their live-born singletons from the Malaria in Pregnancy Preventive Alternative Drugs clinical trial. MiP was assessed using microscopy and real-time quantitative polymerase chain reaction (qPCR). Neurocognitive development in children was assessed using the Mullen Scales of Early Learning and the Kaufman Assessment Battery for Children, 2nd edition (KABC-II), at 1 and 6 years of age, respectively.

Results
Of 493 pregnant women, 196 (40%) were infected with malaria at least once: 121 (31%) with placental malaria diagnosed by qPCR. Multiple linear regression B-coefficients showed that impaired gross motor scores were associated with MiP at least once (−2.55; confidence interval [95% CI]: −5.15, 0.05), placental malaria by qPCR (−4.95; 95% CI: −7.65, −2.24), and high parasite density at delivery (−1.92; 95% CI: −3.86, 0.02) after adjustment. Malaria and high parasite density at the second antenatal care visit were associated with lower KABC-II Non-Verbal Index scores at 6 years (−2.57 [95% CI: −4.86, −0.28] and −1.91 [−3.51, −0.32]), respectively.

Conclusions
This prospective cohort study provides evidence that MiP, particularly late term, could have important negative consequences on child development at 1 and 6 years of age. Mechanisms behind this association must be further investigated and diagnostic methods in low-income countries should be strengthened to provide adequate treatment.

Clinical Trials Registration
NCT00811421.
On the Effect of the Key-Expansion Algorithm in Simon-like Ciphers
Authors: Lu Jinyu , Liu Yunwen , Ashur Tomer , Li Chao 
Published: June 2021

Abstract
In this work, we investigate how the choice of the key-expansion algorithm and its interaction with the round function affect the resistance of Simon-like ciphers against rotational-XOR cryptanalysis. We observe that, among the key-expansion algorithms we consider, Simon is most resistant, while Simeck is much less so. Implications on lightweight ciphers design are discussed and open questions are proposed.
Epicardial origin of cardiac arrhythmias: clinical evidences and pathophysiology
Authors: Chaumont Corentin , Suffee Nadine , Gandjbakhch Estelle , Balse Elise , Anselme Frédéric , Hatem Stéphane N 
Published: June 2021

Abstract
Recent developments in imaging, mapping, and ablation techniques have shown that the epicardial region of the heart is a key player in the occurrence of ventricular arrhythmic events in several cardiac diseases, such as Brugada syndrome, arrhythmogenic cardiomyopathy, or dilated cardiomyopathy. At the atrial level as well, the epicardial region has emerged as an important determinant of the substrate of atrial fibrillation, pointing to common underlying pathophysiological mechanisms. Alteration in the gradient of repolarization between myocardial layers favouring the occurrence of re-entry circuits has largely been described. The fibro-fatty infiltration of the subepicardium is another shared substrate between ventricular and atrial arrhythmias. Recent data have emphasized the role of the epicardial reactivation in the formation of this arrhythmogenic substrate. There are new evidences supporting this structural remodelling process to be regulated by the recruitment of epicardial progenitor cells that can differentiate into adipocytes or fibroblasts under various stimuli. In addition, immune-inflammatory processes can also contribute to fibrosis of the subepicardial layer. A better understanding of such ‘electrical fragility’ of the epicardial area will open perspectives for novel biomarkers and therapeutic strategies. In this review article, a pathophysiological scheme of epicardial-driven arrhythmias will be proposed.
Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking
Authors: Andersson Linda , Cinato Mathieu , Mardani Ismena , Miljanovic Azra , Arif Muhammad , Koh Ara , Lindbom Malin , Laudette Marion , Bollano Entela , Omerovic Elmir , Klevstig Martina , Henricsson Marcus , Fogelstrand Per , Swärd Karl , Ekstrand Matias , Levin Max , Wikström Johannes , Doran Stephen , Hyötyläinen Tuulia , Sinisalu Lisanna , Orešič Matej , Tivesten Åsa , Adiels Martin , Bergo Martin O , Proia Richard , Mardinoglu Adil , Jeppsson Anders , Borén Jan , Levin Malin C 
Published: June 2021

Abstract

Aims
Cardiac injury and remodelling are associated with the rearrangement of cardiac lipids. Glycosphingolipids are membrane lipids that are important for cellular structure and function, and cardiac dysfunction is a characteristic of rare monogenic diseases with defects in glycosphingolipid synthesis and turnover. However, it is not known how cardiac glycosphingolipids regulate cellular processes in the heart. The aim of this study is to determine the role of cardiac glycosphingolipids in heart function.

Methods and results
Using human myocardial biopsies, we showed that the glycosphingolipids glucosylceramide and lactosylceramide are present at very low levels in non-ischaemic human heart with normal function and are elevated during remodelling. Similar results were observed in mouse models of cardiac remodelling. We also generated mice with cardiomyocyte-specific deficiency in Ugcg, the gene encoding glucosylceramide synthase (hUgcg –/– mice). In 9- to 10-week-old hUgcg –/– mice, contractile capacity in response to dobutamine stress was reduced. Older hUgcg –/– mice developed severe heart failure and left ventricular dilatation even under baseline conditions and died prematurely. Using RNA-seq and cell culture models, we showed defective endolysosomal retrograde trafficking and autophagy in Ugcg-deficient cardiomyocytes. We also showed that responsiveness to β-adrenergic stimulation was reduced in cardiomyocytes from hUgcg –/– mice and that Ugcg knockdown suppressed the internalization and trafficking of β1-adrenergic receptors.

Conclusions
Our findings suggest that cardiac glycosphingolipids are required to maintain β-adrenergic signalling and contractile capacity in cardiomyocytes and to preserve normal heart function.