bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on construction safety Evaluation and management system of water conservancy and hydropower projects
Authors: Xiang Jie 
Published: February 2021

Abstract
Along with our country economy sustained and stable growth, water resources and hydropower engineering industry development is rapid, a fairly long period of time in the future will be in the process of engineering construction, however, with the rapid development of water resources and hydropower engineering industries came the frequent safety accidents of water resources and hydropower engineering construction, cause huge casualties and property losses, and has a great influence on society. On the surface, most of the safety accidents are caused by improper human operation or mechanical equipment injury, but at the root of the problem, most of the accidents are caused by potential accidents in safety management. Therefore, how to improve the safety management level of water conservancy and hydropower project construction, improve the level of construction safety management information is the current urgent task of water conservancy and hydropower project construction enterprises.
Experimental study on the influence of temperature on the wear performance of polymer sliding plate materials for bridge bearings
Authors: Niu Songshan , Ouyang Xiankai , Liu Yang 
Published: February 2021

Abstract
The wear performance of polymer sliding plate material for bridge bearing is the key factor affecting the durability of bearing sliding unit. Based on the selection of friction pairs commonly used in bridge bearings in China, the wear performance of modified polytetrafluoroethylene (PTFE) and ultra-high molecular weight polyethylene (UHMWPE) plate, which are gradually used in engineering in recent years, is tested and studied in this paper. It is hoped to provide reference for the engineers and researchers engaged in related work in China.
Preparing ground states with a broken symmetry with variational quantum algorithms
Authors: Vogt Nicolas , Zanker Sebastian , Reiner Jan-Michael , Marthaler Michael , Eckl Thomas , Marusczyk Anika 
Published: February 2021

Abstract
One of the most promising applications for near term quantum computers is the simulation of physical quantum systems, particularly many-electron systems in chemistry and condensed matter physics. In solid state physics, finding the correct symmetry broken ground state of an interacting electron system is one of the central challenges. To help finding the correct broken symmetries in the thermodynamic limit methods that allow to determine the groundstate of large but finite interacting electron systems are very useful. The variational Hamiltonian ansatz (VHA), a variational hybrid quantum-classical algorithm especially suited for finding the ground state of a solid state system, will in general not prepare a broken symmetry state unless the initial state is chosen to exhibit the correct symmetry. In this work, we discuss three variations of the VHA designed to find the symmetry-breaking groundstate of a finite system close to a transition point between different orders. As a test case we use the two-dimensional Hubbard model where we break the symmetry explicitly by means of external fields coupling to the Hamiltonian and calculate the response to these fields. For the calculation we simulate a gate-based quantum computer and also consider the effects of dephasing noise on the algorithms. We find that two of the three algorithms are in good agreement with the exact solution for the considered parameter range. The third algorithm agrees with the exact solution only for a part of the parameter regime, but is more robust with respect to dephasing compared to the other two algorithms.
Silicon carbide planar junctionless transistor for low-medium voltage power electronics
Authors: Nayak Suvendu , SanthiBhushan Boddepalli , Lodha Saurabh , Ganguly Swaroop 
Published: February 2021

Abstract
This paper proposes a Silicon Carbide (SiC) based planar junctionless transistor (JLT), designed and simulated for low to medium power electronic applications, with a calibrated deck of SiC parameters. The simple structure of this device avoids the fabrication complexity associated with intricate junction geometries of vertical power devices and growth challenges of lateral heterostructure ones. Because of the wide bandgap (WBG) of SiC, the device exhibits a breakdown voltage of 100 V at channel length of 0.1 μm, which may be enhanced, at the cost of operating speed, by increasing the channel length. Compared to commercial enhancement-mode GaN (e-GaN) devices with similar breakdown voltage specification, the proposed device offers lower specific on-resistance (R

on,sp
), and a significant reduction in capacitance due to its naturally self-aligned structure, leading to higher operating speed concluded from the mixed-mode simulations.
Predictors of Caregiver Burden in Huntington’s Disease
Authors: Hergert Danielle C , Cimino Cynthia R 
Published: February 2021

Abstract

Objective
Huntington’s disease (HD) is a genetic neurodegenerative condition that is characterized by cognitive, motor, and psychiatric dysfunction. The purpose of this study was to explore which disease characteristics influence caregiver burden in HD.

Methods
Fifty participants with HD and 50 of their caregivers participated in the study at the University of South Florida. Participants were administered a neuropsychological battery, the Unified Huntington’s Disease Rating Scale (UHDRS) motor exam, and the Frontal Systems Behavior Scale (FrSBe) self-report. Caregivers completed the Caregiving Appraisal Scale and the FrSBe family-report.

Results
There were significant correlations between caregiver burden and caregiver age and sex, UHDRS motor scores, cognitive functioning, and self and caregiver-reported FrSBe scores. The significant variables were entered into a regression model and explained 63.1% of the variance in caregiver burden scores. Caregiver age, cognitive functioning, and caregiver-reported FrSBe scores continued to be significant predictors of caregiver burden, whereas the other variables were no longer significant.

Conclusions
There were significant relationships between caregiver burden, cognitive functioning, and frontally mediated behaviors, but not motor scores. The results suggest that possible interventions for caregivers may include education to caregivers on how to cope with apathy/executive dysfunction and cognitive decline. Caregiver age was associated with burden, with younger age being associated with increased burden when controlling for symptom severity. This has implications for this population in that HD typically has a younger age of onset than other neurodegenerative diseases and therefore, these caregivers may be particularly at risk for caregiver burden.
Activation of cardiac sarcoidosis associated with development of gastric cancer: a case report
Authors: Kawai Hideki , Sarai Masayoshi , Toyama Hiroshi , Izawa Hideo 
Published: February 2021

Abstract

Background
The high 18F-fluorodeoxyglucose (FDG) uptake in sarcoidosis lesions reflects infiltration of inflammatory cells such as macrophages. An increased incidence of cancer in patients with sarcoidosis has been suggested, and some combination of the following mechanisms has been proposed: chronic inflammation, immune dysfunction, shared aetiologic agents, and genetic susceptibility to both cancer and autoimmune diseases.

Case summary
A 73-year-old man was admitted to our hospital due to effort dyspnoea. Initial investigations showed complete atrioventricular block on electrocardiography, basal thinning of the interventricular septum, and preserved left ventricular (LV) systolic function on echocardiography, and late gadolinium enhancement (LGE) in all layers of the basal interventricular septum on cardiac magnetic resonance imaging. FDG positron emission tomography/computerized tomography (FDG-PET/CT) showed no abnormal uptake in the whole-body including myocardium. After discussion, corticosteroid was not initiated then. One year later, he developed stomach adenocarcinoma. Repeated investigations demonstrated enlargement of the LV (LV diastolic diameter 63 mm) and diffuse systolic impairment of LV function (LV ejection fraction 31%) on echocardiography, and abnormal focal uptake at the lateral walls of LV and hilar lymph nodes on FDG-PET/CT imaging. One more year after the surgery for gastric cancer and corticosteroid initiation, echocardiography showed recovery of systolic function and FDG-PET/CT showed no uptake in either the myocardium or hilar lymph nodes.

Discussion
In the present case, it is speculated that the first inflammation which left scarred areas showing LGE was already completed before the first FDG-PET/CT. The development of gastric cancer may be associated with the reactivation of cardiac sarcoidosis.
A case report of pulmonary vein isolation with radiofrequency catheter using superior vena cava approach in patient with paroxysmal atrial fibrillation and inferior vena cava filter
Authors: Narikawa Masatoshi , Kiyokuni Masayoshi , Hosoda Junya , Ishikawa Toshiyuki 
Published: February 2021

Abstract

Background
Transseptal puncture and pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF) are generally performed via the inferior vena cava (IVC). However, in cases where the IVC is inaccessible, a specific strategy may be needed.

Case summary
An 86-year-old woman with paroxysmal AF and an IVC filter in situ was referred to our hospital for ablation therapy. An IVC filter for pulmonary embolism and deep venous thrombosis had been implanted 15 years prior, therefore we selected a transoesophageal echocardiography (TOE)-guided transseptal puncture using a superior vena cava (SVC) approach. After the single transseptal puncture, we performed fast anatomical mapping, voltage mapping by multipolar mapping catheter, and then PVI by contact force-guided radiofrequency catheter using a steerable sheath. Following the ablation, bidirectional conduction block between the four pulmonary veins and the left atrium was confirmed by both radiofrequency and mapping catheter. No complications occurred and no recurrence of AF was documented in the 12 months after the procedure.

Discussion
When performing a transseptal puncture during AF ablation, an SVC approach, via access through the right internal jugular vein, enables the sheath to directly approach the left atrium without angulation and improves operability of the ablation catheter. Combining the use of general anaesthesia, TOE, a steerable sheath, and contact force-guided ablation may contribute to achieving minimally invasive PVI with a single transseptal puncture via an SVC approach.
Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials
Authors: Fiolet Aernoud T L , Opstal Tjerk S J , Mosterd Arend , Eikelboom John W , Jolly Sanjit S , Keech Anthony C , Kelly Peter , Tong David C , Layland Jamie , Nidorf Stefan M , Thompson Peter L , Budgeon Charley , Tijssen Jan G P , Cornel Jan H 
Published: February 2021

Abstract

Aims
Recent randomized trials demonstrated a benefit of low-dose colchicine added to guideline-based treatment in patients with recent myocardial infarction or chronic coronary disease. We performed a systematic review and meta-analysis to obtain best estimates of the effects of colchicine on major adverse cardiovascular events (MACE).

Methods and results
We searched the literature for randomized clinical trials of long-term colchicine in patients with atherosclerosis published up to 1 September 2020. The primary efficacy endpoint was MACE, the composite of myocardial infarction, stroke, or cardiovascular death. We combined the results of five trials that included 11 816 patients. The primary endpoint occurred in 578 patients. Colchicine reduced the risk for the primary endpoint by 25% [relative risk (RR) 0.75, 95% confidence interval (CI) 0.61–0.92; P = 0.005], myocardial infarction by 22% (RR 0.78, 95% CI 0.64–0.94; P = 0.010), stroke by 46% (RR 0.54, 95% CI 0.34–0.86; P = 0.009), and coronary revascularization by 23% (RR 0.77, 95% CI 0.66–0.90; P &lt; 0.001). We observed no difference in all-cause death (RR 1.08, 95% CI 0.71–1.62; P = 0.73), with a lower incidence of cardiovascular death (RR 0.82, 95% CI 0.55–1.23; P = 0.34) counterbalanced by a higher incidence of non-cardiovascular death (RR 1.38, 95% CI 0.99–1.92; P = 0.060).

Conclusion
Our meta-analysis indicates that low-dose colchicine reduced the risk of MACE as well as that of myocardial infarction, stroke, and the need for coronary revascularization in a broad spectrum of patients with coronary disease. There was no difference in all-cause mortality and fewer cardiovascular deaths were counterbalanced by more non-cardiovascular deaths.
Alkaline soil pH affects bulk soil, rhizosphere and root endosphere microbiomes of plants growing in a Sandhills ecosystem
Authors: Lopes Lucas Dantas , Hao Jingjie , Schachtman Daniel P 
Published: February 2021

ABSTRACT
Soil pH is a major factor shaping bulk soil microbial communities. However, it is unclear whether the belowground microbial habitats shaped by plants (e.g. rhizosphere and root endosphere) are also affected by soil pH. We investigated this question by comparing the microbial communities associated with plants growing in neutral and strongly alkaline soils in the Sandhills, which is the largest sand dune complex in the northern hemisphere. Bulk soil, rhizosphere and root endosphere DNA were extracted from multiple plant species and analyzed using 16S rRNA amplicon sequencing. Results showed that rhizosphere, root endosphere and bulk soil microbiomes were different in the contrasting soil pH ranges. The strongest impact of plant species on the belowground microbiomes was in alkaline soils, suggesting a greater selective effect under alkali stress. Evaluation of soil chemical components showed that in addition to soil pH, cation exchange capacity also had a strong impact on shaping bulk soil microbial communities. This study extends our knowledge regarding the importance of pH to microbial ecology showing that root endosphere and rhizosphere microbial communities were also influenced by this soil component, and highlights the important role that plants play particularly in shaping the belowground microbiomes in alkaline soils.
Clostridioides difficile phage biology and application
Authors: Heuler Joshua , Fortier Louis-Charles , Sun Xingmin 
Published: February 2021

ABSTRACT
Clostridium difficile, now reclassified as Clostridioides difficile, is the causative agent of C. difficile infections (CDI). CDI is particularly challenging in healthcare settings because highly resistant spores of the bacterium can persist in the environment, making it difficult to curb outbreaks. Dysbiosis of the microbiota caused by the use of antibiotics is the primary factor that allows C. difficile to colonize the gut and cause diarrhea and colitis. For this reason, antibiotics targeting C. difficile can be ineffective at preventing recurrent episodes because they exacerbate and prolong dysbiosis. The emergence of antibiotic resistance in C. difficile also presents a significant threat. The diverse array of bacteriophages (phages) that infect C. difficile could offer new treatment strategies and greater insight into the biology of the pathogen. In this review, we summarize the current knowledge regarding C. difficile phages and discuss what is understood about their lifestyles and genomics. Then, we examine how phage infection modifies bacterial gene expression and pathogenicity. Finally, we discuss the potential clinical applications of C. difficile phages such as whole phage therapy and phage-derived products, and we highlight the most promising strategies for further development.
The RSC complex remodels nucleosomes in transcribed coding sequences and promotes transcription in Saccharomyces cerevisiae
Authors: Biernat Emily , Kinney Jeena , Dunlap Kyle , Rizza Christian , Govind Chhabi K 
Published: February 2021

Abstract
RSC (Remodels the Structure of Chromatin) is a conserved ATP-dependent chromatin remodeling complex that regulates many biological processes, including transcription by RNA polymerase II (Pol II). We report that RSC contributes in generating accessible nucleosomes in transcribed coding sequences (CDSs). RSC MNase ChIP-seq data revealed that RSC-bound nucleosome fragments were very heterogenous (∼80 bp to 180 bp) compared to a sharper profile displayed by the MNase inputs (140 bp to 160 bp), supporting the idea that RSC promotes accessibility of nucleosomal DNA. Notably, RSC binding to +1 nucleosomes and CDSs, but not with -1 nucleosomes, strongly correlated with Pol II occupancies, suggesting that RSC enrichment in CDSs is linked to transcription. We also observed that Pol II associates with nucleosomes throughout transcribed CDSs, and similar to RSC, Pol II-protected fragments were highly heterogenous, consistent with the idea that Pol II interacts with remodeled nucleosomes in CDSs. This idea is supported by the observation that the genes harboring high-levels of Pol II in their CDSs were the most strongly affected by ablating RSC function. Additionally, rapid nuclear depletion of Sth1 decreases nucleosome accessibility and results in accumulation of Pol II in highly transcribed CDSs. This is consistent with a slower clearance of elongating Pol II in cells with reduced RSC function, and is distinct from the effect of RSC depletion on PIC assembly. Altogether, our data provide evidence in support of the role of RSC in promoting Pol II elongation, in addition to its role in regulating transcription initiation.
Assessing the impact of trawling on benthic megafauna: comparative study of video surveys vs. scientific trawling
Authors: Jac Cyrielle , Desroy Nicolas , Duchêne Jean-Claude , Foveau Aurélie , Labrune Céline , Lescure Lyvia , Vaz Sandrine 
Published: February 2021

Abstract
Most studies about benthic community use small-scale sampling methods focused on the infauna such as grabs or box-corers. The benthic data collected by scientific trawl surveys in all European waters, in the frame of the Common Fishery Policy Data Collection Multiannual Program, can be used to study the impact of large-scale fisheries such as trawling. However, the catchability of trawls is very dependent on the nature of the seabed as well as resulting ground-gear adaptations. Due to its non-destructive nature and its ability to focus on benthic macro-epifauna, towed video sampling appears to be a good alternative to monitor the impact of trawling on benthic communities. In the present work, we studied the influence of fishery induced seabed abrasion and video characteristics on nine indices, which can be used to monitor the effect of trawling on benthic communities, was studied. Among them, three indices specific to fishery effect detection based on biological traits appeared to be the best performing benthic indices with video data: modified-Trawling Disturbance Index, partial-Trawling Disturbance Index, and modified sensitivity index. The effectiveness of these indices to monitor the effect of trawling was evaluated and compared between trawl and video sampling. This work has highlighted that video sampling could be a good alternative, or at least a complementary method, to scientific trawling to monitor the effect of trawling on benthic communities in European waters.
The Mosaic mtr Locus as Major Genetic Determinant of Azithromycin Resistance of Neisseria gonorrhoeae—Germany, 2018
Authors: Banhart Sebastian , Selb Regina , Oehlmann Sandra , Bender Jennifer , Buder Susanne , Jansen Klaus , Heuer Dagmar 
Published: February 2021

Abstract
Within the German Gonococcal Resistance Network’s (GORENET) Neisseria gonorrhoeae (NG) sample collection, azithromycin-resistant NG isolates increased from 4.3% in 2016 to 9.2% in 2018. We aim to understand this observed increase using whole genome sequencing of NG isolates combined with epidemiological and clinical data. Reduced susceptibility to azithromycin in 2018 was predominately clonal (NG multiantigen sequence typing G12302) and could mainly be attributed to the recently described mosaic-like mtr locus. Our data suggest that, together with horizontal gene transfer of resistance determinants and well-established point mutations, international spread of resistant lineages plays a major role regarding azithromycin resistance in Germany.
Identification of the relationship between the gut microbiome and feed efficiency in a commercial pig cohort
Authors: Jiang Hui , Fang Shaoming , Yang Hui , Chen Congying 
Published: February 2021

Abstract
Feed efficiency (FE) is an economically important trait in pig production. Gut microbiota plays an important role in energy harvest, nutrient metabolism, and fermentation of dietary indigestible components. Whether and which gut microbes affect FE in pigs are largely unknown. Here, a total of 208 healthy Duroc pigs were used as experimental materials. Feces and serum samples were collected at the age of 140 d. We first performed 16S rRNA gene and metagenomic sequencing analysis to investigate the relationship between the gut microbiome and porcine residual feed intake (RFI). 16S rRNA gene sequencing analysis detected 21 operational taxonomic units showing the tendency to correlation with the RFI (P &lt; 0.01). Metagenomic sequencing further identified that the members of Clostridiales, e.g., Ruminococcus flavefaoiens, Lachnospiraceae bacterium 28-4, and Lachnospiraceae phytofermentans, were enriched in pigs with low RFI (high-FE), while 11 bacterial species including 5 Prevotella spp., especially, the Prevotella copri, had higher abundance in pigs with high RFI. Functional capacity analysis suggested that the gut microbiome of low RFI pigs had a high abundance of the pathways related to amino acid metabolism and biosynthesis, but a low abundance of the pathways associated with monosaccharide metabolism and lipopolysaccharide biosynthesis. Serum metabolome and fecal short-chain fatty acids were determined by UPLC-QTOF/MS and gas chromatography, respectively. Propionic acid in feces and the serum metabolites related to amino acid metabolism were negatively correlated with the RFI. The results from this study may provide potential gut microbial biomarkers that could be used for improving FE in pig production industry.
Retooling the Sustainability Standards in EU Free Trade Agreements
Authors: Bronckers Marco , Gruni Giovanni 
Published: February 2021

ABSTRACT
The EU’s weak promotional policy towards sustainability in its free trade arguments is up for revision. Labour and environmental standards need to be tightened. They were given a boost on balance by a remarkable panel ruling of January 2021 in the long-standing EU–Korea labour dispute. Compliance ought to be subject to regular dispute settlement between governments. Sanctions must be added to the EU’s toolbox, going beyond trade retaliation. Private stakeholders should become more involved in monitoring and enforcement, both at the international and at the domestic level. All this will put an extra responsibility on the EU and its Member States to protect their labour force and the environment as well.