bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medicinal inorganic chemistry: an updated review on the status of metallodrugs and prominent metallodrug candidates
Authors: Miranda Victor M. 
Published: March 2021

Abstract
Metallodrugs correspond to a small portion of all available drugs in the market and, yet, some of them are among the most used and important drugs in modern medicine. However, medicinal inorganic chemistry remains an underestimated area within medicinal chemistry and the main reason is the mislead association of metals to toxic agents. Thus, in this review, the potential of medicinal inorganic chemistry in drug designing is highlighted through a description of the current status of metallodrugs and metallodrug candidates in advanced clinical trials. The broad spectrum of application of metal-based drugs in medicine for both therapy and diagnosis is addressed by the extensive list of examples presented herein.
Etablierte Außenseiter_innen. Zur Sozialfigur des ‚Homo Ethnographicus‘ in der gegenwärtigen US-amerikanischen Soziologie.
Authors: Niermann Debora 
Published: March 2021

Zusammenfassung
Der Beitrag schlägt eine Aktualisierung der sozialfigurativen Beschreibung des homo ethnographicus vor. Ethnograf_innen werden seit Chicago School Gründungstagen als grenzgängerische Außenseiterfiguren porträtiert. Ausgehend von der Annahme enger Verwobenheit figurativsoziologischer und zeitdiagnostischer Beschreibungen gilt es – so die These der Autorin –, angesichts tiefgreifender Restrukturierungen in der gegenwärtigen US-amerikanischen Ethnografielandschaft die Figur der Ethnograf_innen neu zu charakterisieren. Dies geschieht auf empirischer Grundlage mittels „big story“-Analysen biografischer Selbstthematisierungen Ethnografierender. Zentrales Ergebnis sind die Erzählmuster: Wege der Berufung und Wege der Wahl. Die darin vorgenommenen Subjektentwürfe weisen Homologien mit den sozialtheoretischen Grundorientierungen der Ethnograf_innen auf, die in deren Feldbeschreibungen wirksam sind. Ausgehend von diesen empirischen Einblicken, der Beobachtung sozialtheoretischer Ausdifferenzierung und daraus resultierenden Re-Positionierungsleistungen wird abschließend die Rekonzeptualisierung des homo ethnographicus als etablierter Außenseiter formuliert.
un/doing age: Multiperspektivität als Potential einer intersektionalen Betrachtung von Differenz- und Ungleichheitsverhältnissen
Authors: Höppner Grit , Wanka Anna 
Published: March 2021

ZusammenfassungIn der aktuellen Soziologie werden Diskussionen über die Herstellung von sozialen Differenzkategorien, deren Wechselwirkungen und damit einhergehenden Produktionen sozialer Ungleichheitsverhältnisse insbesondere über intersektionale Ansätze geführt. Kritik an intersektionalen Ansätzen richtet sich auf ihre Fokussierung auf eine begrenzte Anzahl bereits gut erforschter Differenzkategorien und auf Konstruktionsprozesse (doings), wobei tendenziell Dekonstruktionsprozesse (undoings) ausgeblendet werden. Der Beitrag greift beide Kritikpunkte auf, um sie für die intersektionale Theoriebildung fruchtbar zu machen. Erstens wird statt auf die klassische Trias ausrace, class,genderdas Differenzmerkmal Alter fokussiert, um dessen Relevanz als ‚metrische Variable‘ deutlich zu machen. Zweitens wird zusätzlich zudoing ageeinundoing ageals Konzept ausgearbeitet. Um die Differenzkategorie Alter einer intersektionalen Betrachtung zugänglich zu machen, entwickelt der Beitrag damit einen multiperspektivischen Analyserahmen.
Nonhomogeneous multicolor laser beams optimization to obtain a stronger intensity single harmonic radiation path
Authors: Jing Xiao-Dan , McCain John , Feng Li-Qiang 
Published: March 2021

Abstract
How to obtain the high signal intensity harmonic spectra with the single harmonic radiation path contribution becomes an important issue in the investigations of the high-order harmonic generation and attosecond science. In this paper, through the nonhomogeneous multicolor laser beams optimization, the best time-spatial laser waveforms, including the positive and negative time-spatial waveforms, to produce the harmonic spectra can be found. As a result, the harmonic plateaus with the single harmonic radiation path contribution and with the enhancement of several orders of magnitudes can be obtained, which can support the generation of the isolated pulses with the durations of 29 as. The physical mechanism behind the improvement of the harmonic spectra is given by the time-spatial profile analyses of the laser pulses and the harmonic spectra.
Parathyroid hormone receptor stimulation induces human adipocyte lipolysis and browning
Authors: Breining Peter , Pedersen Steen B , Kjolby Mads , Hansen Jacob B , Jessen Niels , Richelsen Bjørn 
Published: March 2021

Objective
Activation of brown adipose tissue is a promising strategy to treat and prevent obesity and obesity-related disorders. Activation of uncoupling protein 1 (UCP1) leads to uncoupled respiration and dissipation of stored energy as heat. Induction of UCP1-rich adipocytes in white adipose tissue, a process known as ‘browning’, serves as an alternative strategy to increase whole body uncoupling capacity. Here, we aim to assess the association between parathyroid hormone (PTH) receptor expression and UCP1 expression in human adipose tissues and to study PTH effects on human white and brown adipocyte lipolysis and UCP1 expression.

Design
A descriptive study of human neck adipose tissue biopsies substantiated by an interventional study on human neck-derived adipose tissue cell models.

Methods
Thermogenic markers and PTH receptor gene expression are assessed in human neck adipose tissue biopsies and are related to individual health records. PTH-initiated lipolysis and thermogenic gene induction are assessed in cultured human white and brown adipocyte cell models. PTH receptor involvement is investigated by PTH receptor silencing.

Results
PTH receptor gene expression correlates with UCP1 gene expression in the deep-neck adipose tissue in humans. In cell models, PTH receptor stimulation increases lipolysis and stimulates gene transcription of multiple thermogenic markers. Silencing of the PTH receptor attenuates the effects of PTH indicating a direct PTH effect via this receptor.

Conclusion
PTH 1 receptor stimulation by PTH may play a role in human adipose tissue metabolism by affecting lipolysis and thermogenic capacity.
Health Services Use by Children in the Welfare System Who Died by Suicide
Authors: Ruch Donna A. , Steelesmith Danielle L. , Warner Lynn A. , Bridge Jeffrey A. , Campo John V. , Fontanella Cynthia A. 
Published: March 2021

OBJECTIVES:
To examine characteristics and health service use patterns of suicide decedents with a history of child welfare system involvement to inform prevention strategies and reduce suicide in this vulnerable population.

METHODS:
A retrospective matched case-control design (120 suicide decedents and 1200 matched controls) was implemented. Suicide decedents included youth aged 5 to 21 who died by suicide and had an open case in Ohio’s Statewide Automated Child Welfare Information System between 2010 and 2017. Controls were matched to suicide decedents on sex, race, and ethnicity. Comparisons were analyzed by using conditional logistic regressions to control for matching between the suicide and control groups.

RESULTS:
Youth in the child welfare system who died by suicide were significantly more likely to experience out-of-home placements and be diagnosed with mental and physical health conditions compared with controls. Suicide decedents were twice as likely to access mental health services in the 1 and 6 months before death, regardless of the health care setting. A significantly higher percentage of suicide decedents used physical health services 6 months before their death or index date. Emergency department visits for both physical and mental health conditions were significantly more likely to occur among suicide decedents.

CONCLUSIONS:
Suicide decedents involved in the child welfare system were more likely to use both mental and physical health care services in the months before their death or index date. Findings suggest that youth involved in the child welfare system may benefit from suicide prevention strategies in health care settings.
HASHİMOTO TİROİDİTLİ HASTALARDA ATEROSKLEROZ İLE İLİŞKİLİ PARAMETRELERİN DEĞERLENDİRİLMESİ
Authors: YÜCEL Hakan , TABUR Suzan , ÖZTÜRK Sadettin , ARAZ Mustafa , ÇOLAKOĞLU ER Hale , VURUSKAN Ertan 
Published: March 2021

Amaç
Hashimoto tiroiditi otoimmün tiroid hastalığıdır. Aterosklerozda
arterlerin subintima tabakasında lipidler,
karbonhidratlar, fibröz doku, kalsiyum gibi maddelerin
lokal birikimlerinin oluşturduğu patolojik bir durum
söz konusudur. Vasküler endotelyal büyüme faktör
(VEGF) özellikle hipoksi varlığında seçici olarak endotel
hücrelerinde mitojenik etki ile damar gelişimini
uyararak yeni damar oluşumunda yaşamsal rol oynar.
Biz bu çalışmamızda ötiroid hashimoto hastalarında
serum VEGF düzeyi ile akım aracılı dilatasyon
(flow-mediated dilation, FMD) ve karotis intima media
kalınlığı (KİMK) ölçümü yaparak, otoimmünitenin tiroid
hastalarında ateroskleroz ile ilişkisini ortaya koymayı
amaçladık.
Gereç ve Yöntem
Gaziantep Üniversitesi Tıp Fakültesi Dahiliye Kliniği’nde
Hashimoto tiroiditi tanısı almış 40 hasta ile yaş
ve cinsiyet uyumlu 40 sağlıklı gönüllü çalışmaya dahil
edildi. Serum örneklerinde VEGF düzeyleri ELISA
yöntemiyle ölçüldü. Hasta ve kontrol grubunda ultrason
eşliğinde KİMK ve FMD değerlendirilerek mevcut
sonuçlarla ilişkili olup olmadığı tespit edildi.
Bulgular
Hasta ve kontrol grubunun demografik özellikleri benzerdi.
Hasta ve kontrol grupları arasında FMD ve
KIMK ölçümleri karşılaştırıldığında istatiksel olarak
anlamlı fark saptandı (p=0,001; p=0,033). VEGF düzeyinin
de hasta grubunda kontrol grubuna göre anlamlı
olarak yüksek olduğu tespit edildi (p=0,024).
Sonuç
Tüm bu sonuçlar tiroid hormon eksikliği olmadan da
otoimmüniteye sekonder ateroskleroz gelişebileceğini
ve hashimoto hastalarının erken dönem takiplerinde
noninvaziv uygulanabilen FMD, KİMK ölçümlerinin ve
VEGF düzeylerinin prediktif değerinin olabileceğini
göstermektedir.
Preservation and Access for Born-digital Electronic Records: The Case for an Institutional Digital Content Format Registry
Authors: Rimkus Kyle R. , Anderson Bethany , Germeck Karl E. , Nielsen Cameron C. , Prom Christopher J. , Popp Tracy 
Published: March 2021

ABSTRACT
Since 2014, the University of Illinois at Urbana-Champaign Library has taken custody of a growing number of collections of “born-digital” records, largely through the University Archives. These collections comprise a panoply of digital content formats, ranging from those in common use to obscure varieties from the early days of personal computing. As such, they pose a challenge to digital preservation and access. Knowing what software to use to open files in formats that have fallen out of use is often difficult, let alone installing obsolete software on contemporary operating systems. At the same time, the sheer bulk of collections, as well as an accelerating rate of born-digital accessions from faculty and campus offices, makes it difficult to assess these files at the time of acquisition. These challenges suggest the need for preservation policies on digital formats in collections of electronic records, as well as for firsthand knowledge of the software required to facilitate curator control over and patron access to these collections. This article presents an overview of an evolving approach taken by archivists and librarians at the University of Illinois at Urbana-Champaign to build the policies, technical knowledge, and systems for an effective preservation and access program for electronic records. Their implementation of a local digital content format registry, while young, suggests that archivists and digital preservationists would benefit from further development of tools and practices focused on born-digital formats, and the thoughtful integration of institutional knowledge with international format registries.
Trabajar la historia local de Córdoba con el profesorado en formación de Educación primaria: percepciones sobre el Museo Arqueológico
Authors: Guerrero Elecalde Rafael , López Serrano Miguel Jesús 
Published: March 2021

En estas páginas se encuentran algunos de los resultados de una investigación didáctica llevaba a cabo con el alumnado de tercero del Grado de Educación Primaria de la asignatura de Didáctica de las Ciencias Sociales, de la Universidad de Córdoba, durante el curso académico 2019/2020. Se pretender ver la percepción de nuestro alumnado sobre la utilidad de la investigación sobre la actividad docente presentada para trabajar las Ciencias Sociales. Esta investigación tiene como objetivo conocer la utilidad del museo arqueológico como recurso didáctico pues creemos que es una herramienta útil para el conocimiento del medio más cercano y para el aprendizaje de los procesos históricos más generales, con el establecimiento de un diálogo entre mundos diferentes que se encuentran interconectados: lo particular y lo general, lo concreto y lo abstracto y fenómenos locales con fenómenos comunes. Asimismo, se prestó atención a la didáctica del patrimonio, elemento tan relacionado con el medio donde desarrolla su vida el alumnado. Todo ello con la intención de encontrar caminos que nos ayuden a mejorar la calidad de los procesos de enseñanza-aprendizaje de las Ciencias Sociales. Para ello, ante y después de su realización, se preguntó a los futuros docentes sus impresiones y perspectivas sobre estas cuestiones con el objetivo de recoger respuestas y también cuestiones que hagan reflexionar sobre los contenidos y el diseño de la docencia.
Reflexiones prácticas sobre la competencia judicial internacional y la filiación
Authors: Sánchez Cano María Jesús 
Published: March 2021

A día de hoy, no existe en el Derecho Internacional privado europeo normativa alguna que regule la filiación por naturaleza, motivo por el cual los Tribunales españoles resolverán los con-flictos que se les planteen, aplicando nuestras normas de Derecho Internacional privado de producción interna. El presente trabajo examinará los problemas que suscita en la práctica la aplicación de los foros previstos en el art.22. quáter. d) LOPJ, del cual depende la determinación de la competencia judicial internacional de los Tribunales españoles en materia de filiación. A tal fin, se tomará como punto de partida el Auto de la Audiencia Provincial de Oviedo de 13 de febrero de 2020.
R. Pisillo Mazzeschi. Diritto internazionale dei diritti umani. Teoria e prassi
Authors: Cataldi Giuseppe 
Published: March 2021

Este artículo reseña: R. Pisillo Mazzeschi, Diritto internazionale dei diritti umani. Teoria e prassi, Torino, Giappichelli, 2020, 412 p. ISBN 978-88-9213-251-1.
Pengaruh Model Brain Based Learning terhadap Kemampuan Koneksi Matematis Siswa SMA ditinjau dari Self-Regulated Learning
Authors: Sardi Ayu Lestari , Rahayu Wardani , Sampoerno Pinta Deniyanti 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui terdapat atau tidaknya pengaruh model Brain Based Learning terhadap kemampuan koneksi matematis ditinjau dari Self-Regulated Learning. Penelitian ini menggunakan metode quasi eksperimen dengan desain kontrol post-test kemampuan koneksi matematis. Populasi penelitian ini adalah seluruh siswa kelas X IPA di SMA Muhammadiyah Jakarta pada semester genap Tahun Ajaran 2019/2020 dengan sampel yang diteliti sebanyak 72 siswa. Teknik pengambilan sampel dengan cara cluster random sampling. Pengumpulan data dalam penelitian ini menggunakan instrumen kemampuan koneksi matematis. Sebelum data dianalisis, terlebih dahulu dilakukan uji prasyarat yaitu uji normalitas dengan menggunakan uji kolmogrov smirnov, dan uji homogenitas dengan menggunakan uji levene’s. Berdasarkan hasil analisis data yang menggunakan uji-t diperoleh sebesar 4.603 dan sebesar 1.994 yang mengakibatkan H0 ditolak pada taraf signifikan 0,05 dengan nilai effect size 1,4 yang tergolong tinggi. Oleh karena itu, hasil penelitian ini memiliki kesimpulan bahwa terdapat pengaruh model Brain Based Learning terhadap kemampuan koneksi matematis siswa ditinjau dari Self-Regulated Learning tergolong tinggi.
Upaya Meningkatkan Kemampuan Pemecahan Masalah dan Self-Concept Matematis dengan Pendekatan PMRI di SMP Daar En Nisa Islamic School
Authors: Nidia Rosita  , Rahayu Wardani , Makmuri Makmuri 
Published: March 2021

Penelitian ini bertujuan untuk meningkatkan kemampuan pemecahan masalah dan self-concept matematis di SMP Daar En Nisa Islamic School kelas VIIIA. Penelitian ini merupakan penelitian tindakan kelas (action classroom research) dengan menggunakan model Kemmis and Mc Taggart. Subjek penelitian adalah siswi kelas VIIIA tahun pelajaran 2019/2020 yang berjumlah 27 orang. Penelitian tindakan kelas ini terdiri dari dua siklus, yang setiap siklus terdiri dari 4 tahapan yaitu: perencanaan, pelaksanaan tindakan, observasi dan refleksi. Teknik pengumpulan data menggunakan observasi, wawancara, catatan lapangan, tes, dan dokumentasi. Tes awal yang dilakukan sebelum penelitian dilaksanakan, hasilnya didapatkan rata-rata skor kemampuan pemecahan masalah adalah 33,70 dan skor self-concept matematis sebesar 75,08. Hasil penelitian menunjukkan bahwa pada akhir siklus I terjadi peningkatan rata-rata skor kemampuan pemecahan masalah menjadi 43,40 dan skor self-concept matematis menjadi 78,12. Pada akhir siklus II kembali terjadi peningkatan kemampuan pemecahan masalah dari 43,40 menjadi 75,49 dan self-concept matematis dari 78,12 menjadi 80,33. Berdasarkan uraian di atas dapat disimpulkan bahwa pembelajaran dengan pendekatan PMRI dapat meningkatkan kemampuan pemecahan masalah dan self-concept matematis pada peserta didik kelas VIII A di SMP Daar En Nisa Islamic School Bogor.
Dissociation of a Femoral Intramedullary Magnetic Lengthening Nail During Routine Hardware Removal
Authors: Johnson Mitchell A. , Karkenny Alexa J. , Arkader Alexandre , Davidson Richard S. 
Published: March 2021

Case:
A 15-year-old boy with a right femur length discrepancy secondary to infection underwent hardware removal 1-year status-post right femur osteotomy with placement of an antegrade intramedullary magnetic lengthening nail after successful lengthening of 4.2 cm. During hardware removal, dissociation between the proximal (outer) and distal (inner) components of the device was observed. The distal component was removed using an endoscopic pituitary rongeur after considering multiple possible techniques.

Conclusions:
In the event of nail disconnection during removal of an intramedullary implant, we recommend use of a long pituitary rongeur to retrieve the distal nail component.
Effects of salinity stress on seedling biomass, physiochemical properties and grain yield in different breeding wheat genotypes
Authors: Pour-Aboghadareh Alireza , Mehrvar Mohammad Reza , Sanjani Sara , Amini Ashkboos , Chaman-Abad Hamidreza Nikkhah , Asadi Ameneh 
Published: March 2021

Abstract
The salinity tolerance of 17 breeding wheat genotypes along with three local varieties was evaluated under control and salinity stress (160 mM NaCl) conditions. At the seedling stage, shoot and root dry weights, relative water content (RWC), membrane stability index (MSI), relative chlorophyll content (SPAD index), root and shoot Na+ (RN and SN), root and shoot K+ (RK and SK), root and shoot K+/Na+ ratios (RKN and SKN), root-to-shoot Na+ translocation (RTSN), root-to-shoot K+ translocation (RTSK), stomatal conductance (GS), transpiration rate (TE), and photosynthesis rate (PN) were measured. Moreover, the investigated genotypes were assessed in terms of grain yield across four saline regions during the 2018–2019 cropping seasons. Salinity stress caused a significant reduction in the RDW, SDW, PN, GS, TE, SK, RKN, SKN, RTSN, and RTSK, but resulted in increased RN, RK, and SN. The results of AMMI analysis of variance also indicated significant differences among test locations, genotypes, and their interaction effects. The PCA-based biplot revealed that grain yield strongly correlated with RKN and RK. Furthermore, the correlation among PN, GS, and TE traits was strong and positive and had a positive correlation with RWC, MSI, RDW, and SPAD index. Considering our results, RK and RKN were identified as useful physiological tools to screen salt tolerance at the early-growth stage. According to the ranking patterns obtained by the average sum of ranks method (ASR) and grain yield, we observed that genotype number G5 had considerable physiological potential at the early-growth stage and also responded well to soil salinity at the farm; thus this genotype can be promoted for commercial production.
Mechanical Enhancement of Cellulose Nanofibril (CNF) Films Through the Addition of Water-soluble Polymers
Authors: Forti Endrina Stefani , Awad Sami M El , Ng Xin Y , Cho Whirang , Schueneman Gregory T , Moon Robert J , Fox Douglas M , Youngblood Jeffrey 
Published: March 2021

Abstract
In this work, water-soluble polymers were screened through solution casting and polyvinyl alcohol (PVA) and poly(2-ethyl-2-oxazoline) (PEOX) were found as reinforcement agents for cellulose nanofibrils (CNFs) films. Mechanical property increases of 99% in elastic modulus, 93% in the ultimate tensile strength (UTS) and 134% in the work of failure (WOF) were reported for TEMPO-oxidized cellulose nanofibrils (TOCNF) with 0.44 mmol/g carboxylate groups and 15 wt.% PVA. PEOX had a higher elastic modulus increase of 113%, yet lower UTS and WOF increases were found at 63% and 28%, respectively. Additionally, increases in UTS and elastic modulus were also seen in mechanically fibrillated CNF and TOCNFs with higher carboxylate contents (1.5 mmol/g). The toughening mechanism was attributed to the formation of strong hydrogen bonding between the CNFs and the hydrophilic polymers added. The presence of such mechanisms was indirectly confirmed by tensile testing, zeta potential and rheology.
Integrating past variability in climate-driven Mediterranean fire hazard assessments for 2020-2100
Authors: Lestienne Marion , Vannière Boris , Curt Thomas , Jouffroy-Bapicot Isabelle , Hély Christelle 
Published: March 2021

Abstract
In the Mediterranean basin, Corsica (French island) harbours among the best-preserved Mediterranean forest ecosystems and its high biodiversity could be threatened by the climate and disturbance-regime changes due to the global warming. This study aims i) to estimate the future climate-related fire hazard in Corsica for the current century (2020–2100) based on two RCP scenarios (RCP4.5 and RCP8.5), and ii) to compare the predicted trends with the entire Holocene period for which fire hazard has previously been assessed. An ensemble of future climate simulations from two IPCC RCP scenarios has been used to compute the Monthly Drought Code (MDC) and the Fire Season Length (FSL) and to assess the level of fire hazard assessment. Here, we show that the MDC and the FSL would both strongly increase over the next decades due to the combined effect of temperature increase and precipitation decrease in the Corsica region. Moreover, the maximum Holocene FLS (7000 to 9000 years ago), will be reached (and even exceeded depending upon the scenario) after 2040. For the first time in the Holocene, we may be confronted to an increase in the number of fire-prone months driven by climate combined with many human-caused ignitions. This combination should increase the burned area from 15–140%. For the next 30 years, the game seems to be already played as both RCP scenarios resulted in similar increase in fire hazard intensity and duration. It is thus mandatory to reconsider fire-management and fire-prevention policy to mitigate the future fire risk, and its catastrophic consequences for ecosystems, population, and economy.