bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Regulasi Tegangan AC - DC Menggunakan Filter Pasif
Authors: Prasetyo Agus , D.R Fajar Bima , Matalata Hendi 
Published: March 2021

The adapter / power supply is a DC voltage source that is used to provide voltage or power to various electronic circuits that require DC voltage to operate. The main circuit of the power supply is a rectifier, which is a circuit that converts an alternating signal (AC) into a direct signal (DC). The conversion process starts from rectification by the diode. In this paper, the Ripple Voltage Filter is carried out using a passive filter and the average voltage drop of the filter is 64%, the regulation (regulation) by the regulator circuit, the provision of this DC electrical energy source is to provide a unidirectional variable voltage ( DC) which aims to provide practical tools in Batanghari University electric laboratories while the benefits obtained from the research results are as a tool for practical activities in the electrical engineering laboratory of Batanghari University, Jambi.
Analisis Perbandingan Kuat Tekan dan Kuat Tarik Beton Yang Menggunakan Pasir Sungai Batang Asai Dan Pasir Sungai Batanghari
Authors: Asmara Frans Jovian , Suhendra Suhendra , Dwiretnani Annisaa 
Published: March 2021

Beton adalah material konstruksi yang pada saat ini sudah sangat umum digunakan. Bahan-bahan penyusun beton antara lain agregat kasar, agregat halus, semen, air. Pentingnya mengetahui pemilihan penggunaan material salah satunya agregat halus (pasir), mengingat pasir memliki 4 (empat) tipe zona yang berbeda yaitu pasir kasar, pasir agak kasar, pasir halus, pasir agak halus. yang tentunya ukuran butrian agregat halus yang akan digunakan sebagai bahan dari campuran beton menentukan mutu beton. Penelitian ini menggunakan beton normal, yang merupakan campuran antara air, semen, agregat kasar (batu pecah), agregat halus (pasir), agregat halus yang digunakan berasal dari sungai Batanghari (Ps Bh) dan sungai batang asai (Ps Ba). pada pengujian kuat Tekan beton dan kuat Tarik belah beton dengan mutu f’c = 20 Mpa dan untuk mutu rencana f’cr = 27 Mpa, Benda uji yang digunakan pada penelitian ini berbentuk silinder dengan ukuran diameter 150 mm dan tinggi 300 mm dengan uji kuat tekan beton dilakukan pada umur 7, 14 dan 28 hari, dan untuk uji kuat Tarik belah umur 28hari. Hasil uji kuat tekan kedua jenis benda uji hanya memenuhi f’cnya (20 Mpa) dan tidak memenuhi fc’r (27 Mpa). Hasil uji menunjukkan kedua nilai kuat tekan umur 28hari relatif sama Ps ba = 20,97 Mpa dan Ps Bh = 19,99 Mpa. Untuk kuat Tarik belah betonnya masih termasuk pada batasan kuat Tarik beton normal (9 – 15%) darikuat tekannya. Kuat Tarik belah beton Ps Bh lebih besar dibandingkan beton Ps Ba.
Analisa Penjadwalan Proyek dengan Metode Critical Path Method (CPM) Studi Kasus Pembangunan Gedung Rawat Inap RSUD Abdul Manap Kota Jambi
Authors: Saputra Niko , Handayani Elvira , Dwiretnani Annisaa 
Published: March 2021

Keberhasilan ataupun kegagalan dari pelaksanaan proyek sering kali disebabkan kurang terencananya kegiatan proyek serta pengendalian yang kurang efektif,sehingga kegiatan proyek tidak efisien, hal ini akan mengakibatkan keterlambatan, menurunnya kualitas pekerjaan, dan membengkaknya biaya pelaksanaan. Manajemen proyek dilakukan untuk mengelola proyek dari awal hingga proyek berakhir. Proyek Bangunan Gedung Rawat Inap RSUD Abdul Manap Kota Jambi ini di miliki oleh Pemerintah Kota Jambi merupakan Dana Alokasi Khusus yang dialokasikan dari Pemerintah Pusat, pembangunan ini dilakukan untuk menunjang RSUD naik kelas dari C menuju B. Data yang digunakan pada penelitian ini adalah data sekunder berupa berupa waktu perencanaan proyek/Time Schedule dengan menggunakan CPM (Critical Path Methode) Adapun tujuan dilakukannya penelitian ini adalah Menganalisa Pendjadwalan Proyek dan Mencari jalur kritis pada pekerjaan Pembangunan Gedung Rawat Inap RSUD Abdul Manap Kota Jambi. Berdasarkan hasil analisis dengan menggunakan Critical Path Method maka didapat alur jalur kritis dengan kode pekerjaan : AA,BA,BB,BC,BD,BE,DA,DF,DO,FF,FG. Kurun Waktu Penyelesaian pekerjaan dengan menggunakan Critical Path Methode selama 240 Hari.
Implementasi Keamanan Kaitanya dengan Peraturan Perundang-Undangan pada Lembaga Pemasyarakatan dan Rumah Tahanan Negara
Authors: Mahendra Galih Ihza 
Published: March 2021

The purpose of this research is to know the security arrangement at Penitentiary Institution and House of Detainee against security system of correctional institution and implementation of security in Penitentiary Kuningan. This type of descriptive analysis research with empirical juridical approach. The result of the research stated that the Regulation of Permenkumham Number 33 Year 2015 concerning Security at Penitentiary and House of Detainees has been arranged in detail and complete but in its implementation there are various obstacles so that in Kuningan has not fully applied maximally, especially in guarding and guarding at the time of assimilation which should be supervised and supervised but only accompanied by regular staff assigned. The conclusion is that to optimize security requires human resources and other resources such as technology, infrastructure.
Perlindungan Hak Cipta Seni Batik Jambi Kreasi Modifikasi Di Kota Jambi
Authors: Mahila Syarifa , Tresya Tresya 
Published: March 2021

Traditional Batik Art has been modified by batik artisans, which in the Copyright Act is referred to as contemporary batik art (see article 40 letter J). Modified Batik Art has received protection through the Copyright Act, but not all people understand it. For this reason, it is necessary to study and examine how the legal culture of the community is towards an applicable regulation. This research is an empirical legal research conducted in Jambi City by using an interview method by purposive sampling of respondents who understand the object of study under study. Batik craftsmen in the city of Jambi also develop traditional batik by doing imagination based on their own creativity or also based on the tastes of consumers, but they still consider it not so important as the meaning of registration. The batik craftsmen prioritize maintaining the quality of their work. Some have registered their work as a patent because they consider it more appropriate to register it as a patent related to the process of making batik with priority to quality, which of course requires a separate method
Hak kekayaan Intelektual pada Bisnis Pariwisata Di Kota Wisata Sungai Penuh dan Kabupaten Kerinci
Authors: Oktaviarni Firya , Suryahartati Dwi 
Published: March 2021

The city of Sungai Penuh and Kerinci Regency rely on tourism as a source of regional income supported by natural beauties and cultural diversity of the local communities. Utilizing the potential of nature and culture as assets of regional financial income requires a variety of supporting business components, including hotels, restaurants, culinary, travel agencies, craft arts and its products, performing arts and natural tourism and so on, where all these components shall be utilized optimally. Legal protection of Intellectual Property Rights is needed as well. Based on that, the main legal problem raised in this article is the application of Intellectual Property Rights in the tourism business in the city of Sungai Penuh and Kerinci Regency. This article is sociological juridical study using the qualitative analysis method and both primary and secondary data as research materials. It is shown that the existence of intellectual property rights in both regions has not exercised optimally as there are lacks of understanding on the importance of the existence of intellectual property rights as part of legal protection for local assets in the tourism business in Indonesia. The local governments, supported by academics, shall socialise the importance of intellectual property rights to the community by using the local wisdom approach.
Short Term Complications of Acute Myocardial Infarction in a Tertiary Hospital
Authors: Islam Md Nazrul , Chowdhury Sabikun Nahar , Rahman Md Sajjadur , Hossain Sk Moazzem 
Published: March 2021

Introduction: Acute myocardial infarction is very common in Bangladesh. It is one of the most common causes of mortality worldwide. The clinical course is associated with various complications.
Materials and Methods: To assess the short-term outcome of acute coronary syndrome we select 100 patients. The study was conducted at the Medicine wards of Khulna Medical College Hospital, Khulna from February’2019 to August’2019. We observed the clinical presentations, ECG findings, echocardiographic findings, short term complications and outcome.
Results: We found that most of the patients (61%) were within 45-64 years of age. Chest pain was the most common (85%) presentation. NSTEMI is more common than STEMI. 53% patients developed complications. Acute LVF is the most common (23%) complication. AV block is the most common arrythmia (10%). We found overall mortality 38%.
Conclusion: Early detection of complications is essential for reduction of morbidity and mortality. This study will help to evaluate short-term complications and to give appropriate management.
Medicine Today 2021 Vol.33(1): 42-44
Características e especificidades da Metodologia de Análise de Redes Sociais
Authors: Silva Tarciso Feijó da , Ramos Tatiana Cabral da Silva , David Helena Maria Scherlowski Leal , Vieira Ana Carolina Tavares 
Published: March 2021

Introdução: A relação entre sujeitos, grupos e instituições tem sido objeto de pesquisas em distintas áreas do conhecimento. No campo das Ciências Sociais e da Saúde ela tem contribuído para compreender a estrutura social, a posição dos agentes, relações de afinidade, grau de conectividade, os recursos em circulação e os diferentes capitais em jogo. Na literatura a proposta metodológica da Análise de Redes Sociais desponta como constructo teórico que tem norteado diferentes pesquisas. Objetivo: Apresentar os aspectos teóricos da metodologia de Análise de Redes Sociais, suas características, aplicabilidade e especificidades. Metodologia: Revisão narrativa da literatura desenvolvida entre os meses de fevereiro de 2019 e dezembro de 2020 em publicações científicas como livros, teses, dissertações e artigos, cuja discussão teve por objeto de estudo a metotologia de análide redes sociais. Resultados: Emergiram através da análise dos estudos e foram apresentados a historicidade, os conceitos, as propriedades, a utilização e os principais teóricos relacionados à metodologia de Análise de Redes Sociais. A metodologia permite dupla abordagem quantitativa e qualitativa contribuindo para a observação e apreciação do fluxo de informações entre os indivíduos e visualização gráfica dos sujeitos inseridos em determinado campo. Foi possível apreender a relevância do método para análise da estrutura social e como as relações influem na sua organização e funcionamento. Conclusão: Observou-se que a teoria tem sido potente para pesquisas na área da saúde, seja pela organização do sistema em redes, seja pelo trabalho multiprofissional e interdisciplinar das ações deste campo, contribuindo sobremaneira para reflexão sobre a prática e debates envolvendo políticas, normativas e processo de trabalho.
Assessment of seed cotton yield and fiber properties portrayal of some candidate cotton varieties in national coordinated varietal trials at changing environment of Sindh and Balochistan
Authors: Keerio Abdullah , Anjum Rehana , Channa Abdul Razzaque , Baloch Sultan Ahmed 
Published: March 2021

Thirty six candidate cotton varieties developed by different breeders of Pakistan were tested consecutively for two years (2017 and 2018) and at seven locations of Sindh and Balochista Provinces in national coordinated varietal trials (NCVT). The trials were conducted to explore seed cotton yield potential and fiber properties against two check varieties (CIM-602 and FH-142/IUB-13). As per claim of the breeders, the samples of all varieties for both the years were sent to four designated biotechnological laboratories for conducting biochemical tests also. The results revealed highly significant differences among the varieties for both the years. During the year 2017, on an average of six location, top ten high yielding varieties recorded were GH-Haadi, Weal-AG-6, VH-189, GH-Mubarak, Weal-AG-5, MNH-1026, Badar-1(DG), FH-444, CIM-343 and TJ-Max(DG) which yielded 3434, 3407, 3342, 3255, 3251, 3248, 3185, 3154, 3134 and 3131 kg/ha seed cotton yield respectively. When the results of 2018 trial were looked at, averagely top ten high yielding varieties were GH-Haadi, ICI-2121, CRIS-613, VH-383, VH-189, NIAB-898, FH-490, Cyto-225, Tahafuz-10(DG) and GS-Ali-7 with 3526, 3356, 3306, 3139, 3101, 3091, 3084, 3074, 3060 and 3026 kg/ha of seed cotton yield respectively. However, on an average of both the years (2017 and 2018), top ten high yielding varieties were GH-Haadi, VH-189, CRIS-613, Weal-AG-6, GH-Mubarak, Badar-1(DG), ICI-2121, Weal-AG-5, FH-940 and MNH-1026 producing 3480, 3221, 3186, 3155, 3113, 3083, 3057, 3054, 3042 and 3042 kg/ha of seed cotton respectively. As regards fiber properties, (04 candidate varieties) could qualified all fiber standards set by government. The biochemical test results received from all four laboratories revealed that on an average of four laboratories and two years, the trait purity range recorded was from 42 to 96 percent, whereas, quantification of Bt toxin ranged from 0.74 to 2.62. From the present study, it was concluded that almost 15-20 candidate varieties have the potential to be included among already approved varieties for commercial cultivation in the province of the Punjab.
Mobile Pulmonary Rehabilitation: Feasibility of Delivery by a Mobile Phone-Based Program
Authors: Whittaker Robyn , Dobson Rosie , Candy Sarah , Tane Taria , Burrowes Kelly , Reeve Julie , Tawhai Merryn , Taylor Denise , Robertson Trina , Garrett Jeffrey , Humphrey Gayl , Brott Tamzin , Khan Sabaoon Raza , Hu Feiyu , Warren Jim 
Published: March 2021

Background: Pulmonary rehabilitation (PR) has been proven effective but is not well accessed due to transport, time, cost, and physical limitations of patients. We have developed a mobile phone-based PR program (mPR) that could be offered as an alternative for those unable to attend in-person. This was developed following formative research with patients, their families and clinicians. mPR has a core text message program plus an app that includes an action plan, exercise videos, lung visualization, symptom score questionnaire and 1-min sit-to-stand test.Aims: To determine the feasibility of delivering pulmonary rehabilitation by mobile phone.Methods: A 9-week non-randomized (1-arm) pilot study was conducted. Participants were 26 adults with chronic obstructive pulmonary disease plus four family members, who were offered participation at first assessment or during group PR sessions. Outcomes included satisfaction, engagement with the program, and perceived impacts.Results: Eight people (31%) opted for text messages only, and 18 (69%) chose text messages plus the app. Three people stopped the program early, 20 said they would recommend it to others, 19 said it helped them to feel more supported, 17 said it helped them to change their behavior.Conclusion: It is feasible to deliver PR support via mobile phone, including exercise prescription and support. Our mPR program was appreciated by a small number of people with chronic respiratory disorders and family members. Suggestions for improvements are being used to inform the further development of the program, which will then be tested for effectiveness. Registered with the Australia New Zealand Clinical Trials Registry ACTRN12619000884101 (www.anzctr.org.au).
Impact of Serum Uric Acid Lowering and Contemporary Uric Acid-Lowering Therapies on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Authors: Ying Hangying , Yuan Hongdi , Tang Xiaomei , Guo Wenpu , Jiang Ruhong , Jiang Chenyang 
Published: March 2021

Objective: This study aimed to evaluate the potential association between uric acid (UA) lowering and cardiovascular risk reduction among UA-lowering therapies in adults.Methods: A systematic search for randomized controlled trials (RCTs) was conducted according to the protocol pre-registered in PROSPERO (No. CRD42020199259). We search for RCTs in PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov up to July 1, 2020. A meta-analysis was performed using a fixed- or random-effects model.Results: In total, 30 studies involving 18,585 hyperuricaemic patients were included. Xanthine oxidase inhibitor (XOI) therapy produced a 6.0% reduction in relative risk (RR) for major adverse cardiovascular events (MACEs). The use of febuxostat was associated with a higher risk of cardiovascular events (CVEs) (RR: 1.09, 95% CI 0.998–1.19, I2 = 0.0%), but the difference was not statistically significant. Allopurinol treatment was associated with a lower CVE risk (RR: 0.61, 95% CI 0.46–0.80, I2 = 21.0%). Among the UA-lowering therapies, the drug treatments were associated with all-cause mortality (RR: 1.20, 95% CI 1.02–1.41, I2 = 0.0%). The subgroup with a UA endpoint &lt;7 mg/dl was not associated with a higher CVE risk (RR: 0.57, 95% CI 0.35–0.92, I2 = 0.0%), and in the subgroup with a UA endpoint &lt;5 mg/dl group, a lower risk of CVEs was not observed (RR: 0.99, 95% CI 0.69–1.44, I2 = 0.0%).Conclusions: UA reduction caused by XOIs reduced the incidence of MACEs. UA-lowering medicines were associated with changes in all-cause mortality but not cardiovascular outcomes. The lower UA endpoint was not associated with reduced cardiovascular risk.
Integrated Analysis of ceRNA Regulatory Network Associated With Tumor Stage in Cervical Cancer
Authors: Ma Xiaojie , Zhang Qian , Du Jiayu , Tang Jie , Tan Bangxian 
Published: March 2021

ObjectiveTo analyze the abnormally expressed genes involved in cervical cancer occurrence and development.Materials and MethodsIntegrated bioinformatics methods were used to analyze differentially expressed (DE) RNAs, including mRNAs, microRNAs (miRNAs), and long non-coding RNAs (lncRNAs), in stage I, II, III, and IV cervical cancer patients from the TCGA database to fully reveal the dynamic changes caused by cervical cancer.ResultsFirst, DE RNAs in cervical cancer tissues from stage I, II, III, and IV patients and normal cervical tissues were identified and divided into different profiles. Several DE RNA profiles were down-regulated or up-regulated in stage I, III, and IV patients. GO and KEGG analysis of DE mRNA profile 1, 2, 4, 5, 6 and 22 which were significantly down-regulated or up-regulated showed that DE mRNAs are involved in cell division, DNA replication, cell adhesion, the positive and negative regulation of RNA polymerase ll promoter transcription. Besides, DE RNA profiles with significant differences in patient stages were analyzed to perform a competing endogenous RNA (ceRNA) regulatory network of lncRNA, miRNA, and mRNA. The protein-protein interaction (PPI) network of DE mRNAs in the ceRNA regulatory network was also constructed. The network had nine central genes (up-regulated genes: CDKN2A, GSK3B, BIRC5, CYCS, MAD2L1; down-regulated genes: PTEN, FOXO3, CCND2, TGFBR2). Survival analysis found that 5 lncRNAs, 9 mRNAs, and 4 miRNAs can be used as prognostic indicators of cervical cancer. Finally, combined with cluster analysis results, we further screened 2 DE RNAs (AMZ2P1 and HDAC5) using clinical samples, suggesting that AMZ2P1, and HDAC5 may act as diagnostic biomarkers for the development of cervical cancer.ConclusionThis research provides new effective targets and reliable biological markers for the diagnosis and prognosis of cervical cancer.
Antigenic Challenge Influences Epigenetic Changes in Antigen-Specific T Regulatory Cells
Authors: Iwaszkiewicz-Grzes Dorota , Piotrowska Magdalena , Gliwinski Mateusz , Urban-Wójciuk Zuzanna , Trzonkowski Piotr 
Published: March 2021

BackgroundHuman regulatory T cells (Tregs) are the fundamental component of the immune system imposing immune tolerance via control of effector T cells (Teffs). Ongoing attempts to improve Tregs function have led to the creation of a protocol that produces antigen-specific Tregs, when polyclonal Tregs are stimulated with monocytes loaded with antigens specific for type 1 diabetes. Nevertheless, the efficiency of the suppression exerted by the produced Tregs depended on the antigen with the best results when insulin β chain peptide 9-23 was used. Here, we examined epigenetic modifications, which could influence these functional differences.MethodsThe analysis was pefromed in the sorted specific (SPEC, proliferating) and unspecific (UNSPEC, non-proliferating) subsets of Tregs and Teffs generated by the stimulation with monocytes loaded with either whole insulin (INS) or insulin β chain peptide 9-23 (B:9-23) or polyclonal cells stimulated with anti-CD3/anti-CD28 beads (POLY). A relative expression of crucial Tregs genes was determined by qRT-PCR. The Treg-specific demethylated region (TSDR) in FoxP3 gene methylation levels were assessed by Quantitative Methylation Specific PCR (qMSP). ELISA was used to measure genomic DNA methylation and histone H3 post-translational modifications (PTMs).ResultsTregs SPECB:9-23 was the only subset expressing all assessed genes necessary for regulatory function with the highest level of expression among all analyzed conditions. The methylation of global DNA as well as TSDR were significantly lower in Tregs SPECB:9-23 than in Tregs SPECINS. When compared to Teffs, Tregs were characterized by a relatively lower level of PTMs but it varied in respective Tregs/Teffs pairs. Importantly, whenever the difference in PTM within Tregs/Teffs pair was significant, it was always low in one subset from the pair and high in the other. It was always low in Tregs SPECINS and high in Teffs SPECINS, while it was high in Tregs UNSPECINS and low in Teffs UNSPECINS. There were no differences in Tregs/Teffs SPECB:9-23 pair and the level of modifications was low in Tregs UNSPECB:9-23 and high in Teffs UNSPECB:9-23. The regions of PTMs in which differences were significant overlapped only partially between particular Tregs/Teffs pairs.ConclusionsWhole insulin and insulin β chain peptide 9-23 affected epigenetic changes in CD4+ T cells differently, when presented by monocytes. The peptide preferably favored specific Tregs, while whole insulin activated both Tregs and Teffs.
Polyethylene Glycol Ointment Alleviates Psoriasis-Like Inflammation Through Down-Regulating the Function of Th17 Cells and MDSCs
Authors: Lu Yan , Xiao Yi , Yin Ming-Zhu , Zhou Xing-Chen , Wu Li-Sha , Chen Wang-Qing , Luo Yan , Kuang Ye-Hong , Zhu Wu 
Published: March 2021

Objective: To explore the possible mechanism of improving the imiquimod (IMQ)-induced psoriasis-like inflammation by using polyethylene glycol (PEG) ointment.Methods: We evaluated the appearance of psoriasis lesions by Psoriasis Area and Severity Index (PASI), observed the epidermal proliferation by histopathological staining and immunohistochemical staining, and explored the key molecules and signaling pathways of improving psoriasis-like inflammation treated with PEG ointment by RNA sequencing. Finally, we verified the expression of inflammatory cells and inflammatory factors by flow cytometry, immunohistochemical staining, and Q-PCR.Results: PEG ointment could improve the appearance of psoriasis lesions and the epidermis thickness of psoriasis mouse, inhibit the proliferation of keratinocytes, and down-regulate the relative mRNA levels of IL-23, IL-22, IL-6, IL-17C, IL-17F, S100A7, S100A8, S100A9, CXCL1, CXCL2, and IL-1β in the skin lesions of psoriasis mouse by down-regulating the numbers of myeloid-derived suppressor cells (MDSCs) and T helper 17 (Th17) cells.Conclusion: PEG ointment could improve the IMQ-induced psoriasis-like inflammation by down-regulating the functions of Th17 cells and MDSCs.