bluuebunny/crossref_metadata_2025_split huggingface dataset:
An experimental study using known variants of transport immobilization and comparing them with the original temporary splint for the treatment of jaw fractures
Authors: Mitin N. E. , Zolotova Maria I. , Mitina E. N. 
Published: January 2021

Academician I.P. Pavlov Ryazan state medical University of the Ministry of health of the Russian Federation, 390026, Ryazan, Russian Federation
Patients with injuries of the maxillofacial region make up about 30% of all patients treated in the in-patient departments of maxillofacial surgery. Meanwhile, fractures of the lower jaw account for about 70%85% of all fractures of the bones of the face. The need for immobilization is due to the risk of pain and complications (bleeding, microbial contamination, asphyxiation, damage to nerves and blood vessels). The article provides a comparative analysis between temporary immobilization of the jaws using well-known designs and a new universal temporary bus with a channel. We conducted the experiment under simulated conditions using the following splinting structures: a smooth splint bar and a patented temporary splint with a channel for treating jaw fractures (Application No. 2020103350/14 (005106) (22) Application submission date 27.01.2020). From the experimental research complex, it was possible to verify that the methods of temporary splinting of the jaws have their own characteristics of superposition and displacement of structures. It is worth noting that the displacement of jaw fragments occurred in each splinting and this should definitely be taken into account at the stage of first aid. The study also revealed that that the splinting technique for the splint has a number of disadvantages, the most significant of which are the negative impact on periodontal disease, a significant decrease in oral hygiene, and the possibility of secondary infection. Among the obvious advantages of a universal temporary bus with a channel, include the simplicity of applying and fixing fragments, the ability to supply the patient, receive fluids and drugs through the probe, as well as ensuring full breathing in the absence of nasal breathing.
Expression of CD44, CD29 and osteocalcin differentiation factors in the alveolar bone during past fixation of a free gingival graft
Authors: Edranov S. S. , Matveeva Natalya Yu. , Kalinichenko S. G. 
Published: January 2021

Aim: To study the localization of stem stromal cells on the surface of a free gingival graft.
Material and methods: We studied the immunolocalization of stem cell markers (CD29, CD44 and osteocalcin) the mucosa plate and bone tissue of the lower jaw of outbred miniature pigs with bone fixation of a free gingival graft.
Results: In the third month after the operation, a new bone tissue is formed in the contact area, characterized by formed bone plates, osteons, and a system of Havers and Volkman channels. When studying the immunolocalization of CD29, CD44, and osteocalcin, we detected a heterogeneous distribution. CD29and CD44-immunopositive cells prevail at the border of the newly formed bone and its own gingival plate, as well as in the cavity of the Havers canals. Osteocalcin-positive cells are localized mainly in the layer of common plates, on the surface of the bone plates of osteons surrounding the Havers channel and in its cavity, which are in close proximity to the graft.
Conclusion: Bone fixation of SDT remodels the alveolar bone, showing signs of a reparative process. The presence of expression of CD29 and CD44 in bone tissue indicates the activation of mesenchymal cambial cells, which differentiate into osteocalcin-containing osteoblasts. The inducing role of a free gingival graft in the formation of a new bone is determined by the ability of its cells to synthesize trophic factors stimulating the proliferation and differentiation of MSC and vascular growth. Thus, the model on miniature pigs is a useful tool for studying this process.
Dynamics of hygienic and periodontal indices at the stages of implantological treatment
Authors: Ivanov A. S. , Sakaeva Z. U. , Morozov D. I. , Martynov D. V. , Salamov M. Y. , Olesov Egor E. , Olesova E. A. 
Published: January 2021

The level of oral hygiene among many patients with implants is insufficient. In the absence of clinical examination and occupational hygiene, there is an averagely frequent development of inflammation in peri-implant tissuesperi-implantitis, which can cause implant disintegration. It is necessary to control hygiene indicators at the different stages of implantation.
Objective: to analyze changes in hygiene and periodontal parameters during implant treatment.
Materials and methods: At the stages before implantation, during osseointegration and the year after prosthetics on implants, the hygiene indicators and periodontal and microbiota status of 60 patients with dental implants were analyzed. Control methods used include Oral Hygiene Index Green J.C., Vermillion J.R. (OHI-S); gingivitis index Loe H., Silness J. (GI); Muhllemann index modified by Cowell; and PMA index modified by Parma. The level of halitosis was determined using the organoleptic index and the Halimeter instrument. Molecular genetic diagnosis of periodontopathogenic bacteria in the periodontal and peri-implant space was carried out.
Results: Hygiene and periodontics after preimplantation tooth restoration, and periodontal deterioration by the time the implants open, then before replacing the temporary prostheses with permanent ones and after three months of functioning of the prostheses on the implants, which necessitates professional oral hygiene before these stages.
Conclusion. Occupational hygiene every three months provides a stable adequate level of hygienic and periodontal indicators for users of prostheses on implants, and also reduces the detection of peri-implantitis.
Pyoderma gangrenosum of the hand: a missed diagnosis and lessons learned
Authors: Maheshwari K. , Yousif A. , Burova E. 
Published: January 2021

INTRODUCTION: Pyoderma gangrenosum (PG) is a challenging condition to diagnose and treat.
CASE REPORT: We discuss the case of a man who presented with a swollen and extremely tender finger, with bullous lesions, erythema, and a clinical picture suggestive of a necrotising fasciitis. He had a history of ulcerative colitis (UC) and had been taking azathioprine. Initial debridement of the affected tissues was carried out as an emergency, with no improvement. Pyoderma gangrenosum had been suspected at that stage and the patient was prescribed oral Prednisolone. He showed a remarkable recovery and his finger healed completely. Due to a persistent pancytopenia he underwent further tests and was subsequently diagnosed with Acute myeloid leukaemia (AML).
DISCUSSSION: Pyoderma gangrenosum is a diagnosis of exclusion. It can be a sign of internal malignancy and other medical conditions. Therefore, a low threshold must be kept for the diagnosis of this disorder, especially in patients with known risk factors.
CONCLUSION: Based on our experience, in similar clinical scenarios, we suggest limb elevation and antibiotics initially, with a close observation and consideration of the diagnosis of pyoderma gangrenosum prior to any surgical intervention. A thorough investigation of the possible reasons for PG is vitally important.
Impact of Covid-19 on Islamic Stock Markets: An Investigation using Threshold Volatility and Event Study Models
Authors: Irfan Mohammad , Kassim Salina , Dhimmar Sonali 
Published: January 2021

The Covid-19 is an unexpected event in the world history with substantial socio-economic impact on the global economy. The global financial market was also badly affected as reflected by the extreme volatility as well as weak performances in the stock markets all over the world. How do the Islamic stock markets in various parts of the world behave during the Covid-19 shock? The objective of this study is to identify the impact of the Covid-19 pandemic as declared by the World Health Organization on the Islamic stock markets. Using the threshold volatility and event study models, the study analyses the impact of the Covid-19 announcement on the Islamic stock indices in the Indian Stock Exchange (represented by the Bombay Stock Exchange - BSE Shariah Index) and Indonesian Stock Exchange (represented by the Jakarta Islamic Indices - JII). With the date of event identified as 11th March 2020, the event window consists of 60, 30, and 20 days. The results show that the BSE Shariah and JII have positive coefficients, with the BSE Shariah Index shows negative response to the announcement of Covid-19 as global pandemic. On the other hand, the JII reacted positively to the event. The study shows the reaction of a stock exchange is dependent on other economic factors unique to the country, resulting in the events impact of the Covid-19 to vary from one country to another.
Study of Maternal and Foetal Outcome in Abruptio Placentae
Authors: Lokhande Vikram , Jadhav Kunal , Kadam Minal , Rawte Suresh 
Published: January 2021

Study of Maternal and Foetal outcome in Abruptio Placentae
Introduction: Abruptio placentae (AP) is a significant obstetrical emergency and as per WHO 2009 maternal mortality rates reported due to AP worldwide was 2.1% and fetal perinatal mortality rate was 15%. AP cannot be prevented but maternal and perinatal morbidity and mortality due to AP can be reduced significantly by aggressive management.
Methods: The present prospective study was conducted to evaluate the outcome of treatment on the perinatal and maternal outcome in Abruptio Placentae patients in a tertiary care hospital from January 2015 to January 2016 amongst 54 pregnant women diagnosed to have abruptio placentae from 28 weeks of gestation and above and all babies delivered. Face-to-face interviews was conducted. Results: Maximum no. of abruptio placentae were unbooked - 37 (69%) and 85% of patients belonged to the less than 30 years of age group. An abruptio placenta was more common in multipara. Anaemia was seen in 21 patients (38%). Anaemia and PIH was seen in 12 patients (23%). 7 patients had fetal distress at the time of admission (13%). Regarding mode of delivery, 50% of patients delivered vaginally by artificial rupture of membrane (ARM) and oxytocin augmentation and 50% underwent caesarean section. Conclusion: It was concluded that abruptio placentae is still a leading cause of maternal morbidity and mortality that can be reduced with modern management of abruptio placentae, but timely diagnosis and intervention is necessary.
Key Words: Abruptio placentae, maternal mortality, fetal distress, anaemia
MEDIA INTERNET SEBAGAI SARANA EDUKASI PADA ANAK USIA DINI TENTANG COVID-19
Authors: Prasetiyo Aji 
Published: January 2021

<p align="justify">Edukasi tentang virus covid-19 pada anak menjadi sebuah kebutuhan yang harus dipenuhi. Infeksi virus corona merupakan penyakit yang menyerang sistem pernapasan. Menurut merdeka.com menunjukkan, kasus Covid-19 di Indonesia sudah menembus angka 76.981 orang. Terjadi penambahan sebanyak 1.282 kasus baru. Jumlah pasien sembuh dari Covid-19 bertambah 1.051 orang. Penambahan ini membuat total kasus sembuh di Indonesia mencapai orang 36.689 orang. Sementara kasus kematian karena Covid-19 juga bertambah 56 orang. Total akumulatif kasus kematian akibat Covid-19 menjadi 3.656 orang. Penderita covid-19 sejauh ini cenderung kebanyakan adalah orang dewasa. Namun, kasus pada anak-anak telah dilaporkan, termasuk pada balita. Media internet sebagai metode pengenalan covid pada anak usia dini dipandang lebih interaktif dan tidak membosankan dengan memanfaatkan platform-platform yang tersedia di jejaring internet.</p><p align="justify"><strong>Kata kunci : covid-19, internet, anak usia dini </strong><strong></strong></p>
KEBIJAKAN MUSEUM SONOBUDOYO YOGYAKARTA DALAM MENGATASI KLAIM KEPEMILIKAN WARISAN BUDAYA
Authors: Purnama Rendi , Zulaikha Sri Rohyanti 
Published: January 2021

Penelitian ini bertujuan untuk menjelaskan kebijakan yang diambil oleh Museum Sonobudoyo Yogyakarta dalam mengatasi kejahatan-kejahatan yang terjadi yang bisa merugikan pihak Museum dan masyarakat umum. Penelitian ini menggunakan metode deskriptif kualitatif yang melalui pendekatan studi kasus yang terjadi di Museum Sonobudoyo Yogyakarta. Hasil penilitian ini adalah Kebijakan yang diambil oleh Museum Sonobudoyo adalah dengan tidak lagi mempublikasikan data-data manuskrip ataupun naskah-naskah lain untuk meminimalisir pencurian dan klaim kepemilikan yang terjadi. Manuskrip yang didigitalisasi hanya dipublikasikan kepada orang-orang yang ada di ruang lingkup museum saja. Sehingga tidak ada pulikasi kepada masyarakat umum untuk menghindari hal-hal yang tidak diinginkan. Jika ingin melihat manuskrip dan naskah-naskah kuno bisa langsung datang ke Museum Sonobudoyo
Sea-spray aerosols and SARS-Cov-2: an analysis using AERONET data
Authors: Piazzola Jacques , Desnues Christelle , Parent Philippe , Yohia Christophe , Canepa Elisa 
Published: January 2021

Abstract
Even if the people density, habits and displacements probably represent the most important causes of the SARS-Cov-2 virus propagation, the role of the atmospheric aerosol in COVID-19 outbreaks is significant and it needs to be further investigated. Therefore, we aimed to study if the aerosol properties related to the different sources and meteorological conditions we can observe in continental and coastal urbanized areas can have an influence on the atmospheric transport of the SARS-Cov-2 virus. This paper focuses on the lockdown period to reduce the differences in the social behavior. As an example, we investigated the contamination cases during March 2020 in two specific French areas located in both continental and coastal areas with regard to the meteorological conditions and the corresponding aerosol properties. To this end, we used both the optical depth (AOD) and the Angstrom exponent provided by the AERONET network. The results show that the analysis of aerosol ground-based data can be of interest to assess a virus survey. In particular, our data show that moderate to strong onshore winds occurring in coastal regions, which allow large sea-spray production episodes, deal with smaller COVID-19 contamination rates. This suggests that the coagulation of SARS-Cov-2 viral particles with hygroscopic salty sea-spray aerosols would tend to inhibit its viral infectivity via possible reaction with NaCl, especially in high relative humidity environments. Capsule: Our results suggest that maritime air-masses limit the SARS-Cov-2 impact via the role of the sea-spray.
Chemical templates that assemble the metal superhydrides
Authors: Sun Yuanhui , Miao Maosheng 
Published: January 2021

Abstract
The recent incessant discoveries of high-pressure hydrides totally altered our road map toward finding room temperature superconductors. Especially, metal superhydrides consisting of hydrogen covalent networks that resemble metallic hydrogen are favorable candidates for improving Tc and lowering pressure. However, the chemical force that drives the dissociation of H2 and the formation of H covalent network in superhydrides is unknown. Our high-throughput calculations show that, after removing H atoms, the remaining metal lattices exhibit unusual electron occupations at the interstitial regions, which matches excellently to the H lattice like a template. Furthermore, H lattices consist of 3D aromatic building units that are greatly stabilized by chemical templates of metals close to s-d boarder. The theory can help predicting ternary superhydrides that may form at lower pressure.
Deficiency and absence of endogenous isoprene in adults, disqualified its putative origin
Authors: Sukul Pritam , Richter Anna , Schubert Jochen K , Miekisch Wolfram 
Published: January 2021

Abstract
Background: Isoprene (C5H8) is a clinically important breath metabolite. Although, hundreds of studies have reported differential expressions in isoprene exhalation as breath biomarker for diverse diseases, the substance couldn’t enter to clinical practice as diagnostic marker. Moreover, many experimental/basic observations upon breath isoprene remained unrelated to the corresponding pathophysiological effects on its putative metabolic origin (i.e. mevalonate pathway). Here, we investigated the fundamental reason that hindered the rational interpretation and translation of this marker from basic to clinical science. Methods: Via high-resolution mass-spectrometry based breathomics in 1026 human subjects, we discovered adults with significant deficiency (order of magnitude lower than the normal) and complete absence of breath isoprene. We prospectively applied real-time breathomics, quantitative gene expression analysis of the mevalonate pathway enzymes, lipid-profiling and hemodynamic monitoring on those isoprene deficient subjects and controls. Additionally, the subject with absence of isoprene was followed up throughout different phases of her womanhood.Results: In contrast to convention, we witnessed that adults can live healthy without exhaling isoprene or with significant deficiency. This rare phenotype represents a recessive inheritance. Despite physio-metabolic changes during menstrual cycle (that is known to profoundly affect isoprene exhalation) and profoundly increased plasma cholesterol during pregnancy and after childbirth, isoprene remained absent. All genes of mevalonate pathway enzymes were normally expressed in all participants, without any down-regulation or compensatory up-regulation. Conclusions: Absence/deficiency of isoprene despite normal lipid profiles and no mevalonate pathway malfunction disqualifies the long-believed metabolic origin of isoprene from cholesterol biosynthesis. Thus, clinical translation of breath isoprene expressions should not be generally attributed to corresponding pathophysiological effects onto mevalonate/cholesterol pathway. Our finding has refined and optimized the clinical interpretation of isoprene as biomarker in volatile metabolomics and breathomics. Future studies will address the correct metabolic origin of isoprene to imply this important marker to routine practice.
Polymorphisms of rs2483205 and rs562556 in Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gene are Associated With Coronary Artery Disease
Authors: Gai Min-Tao , Adi Dilare , Chen Xiao-Cui , Liu Fen , Xie Xiang , Yang Yi-Ning , Gao Xiao-Ming , Ma Xiang , Fu Zhen-Yan , Ma Yi-Tong , Chen Bang-dang 
Published: January 2021

Abstract
PCSK9 plays a pivotal role in lipid metabolism. The present study is to explore the potential novel single nucleotide polymorphisms (SNPs) of the PCSK9 gene which is associated with coronary artery disease (CAD) in the Han population who lived in Xinjiang, China. We conducted a case-control study and genotyped four tag SNPs of the PCSK9 gene in 950 CAD and 1082 health subjects in the Han population. This study showed that for rs2483205, the distributions in genotypes had significant differences between the CAD and control groups (p = 0.025), and the subjects with TT genotype had lower total cholesterol (TC) level than CT genotype (p = 0.025). For rs562556, there were significant differences between the CAD and control groups for distributions of genotypes (p = 0.020), and the individuals with a G allele had a lower low-density lipoprotein cholesterol (LDL-C) level than an A allele (p = 0.048). Furthermore, the TT genotype of rs2483205 and GG genotype of rs562556 were independently associated with CAD (odds ratio [OR] = 0.53, 95% confidence interval [CI] = 0.29-0.95, p = 0.032 and OR = 0.57, 95%CI = 0.34-0.95, p = 0.032, respectively). In conclusion, the rs2483205 and rs562556 were significantly associated with CAD.
Glycemic Control and Neonatal Outcomes in Women With Gestational Diabetes Mellitus Treated Using Glyburide, Metformin, or Insulin: A Pairwise and Network Meta-Analysis
Authors: Yu Dan-Qing , Xu Guan-Xin , Teng Xin-Yuan , Xu Jing-Wei , Tang Liang-Fang , Feng Chun , Rao Jin-Peng , Jin Min , Wang Li-Quan 
Published: January 2021

Abstract
Aims: We aimed to assess the comparative efficiency and safety of the use of glyburide, metformin, and insulin in gestational diabetes mellitus (GDM).Methods: We searched for randomized controlled trials that compared glyburide, metformin, and insulin in GDM. Data regarding glycemic control and neonatal safety were collected and analyzed in pairwise and network meta-analyses.Results: A total of 4,683 individuals from 24 trials were included. Compared with glyburide, metformin reduced 2-hour postprandial blood glucose (2HPG) to a greater extent (standard mean difference (SMD) 0.18; 95% credible interval (CI) 0–0.36). There were significantly lower prevalences of neonatal hypoglycemia (risk difference (RD) −0.07; 95%CI−0.11–−0.03), neonatal intensive care unit (NICU) admission (RD−0.03; 95%CI−0.06–−0), and preeclampsia (RD−0.03; 95%CI−0.06–−0) in the metformin group than in the insulin group. The metformin group had significantly lower birth weight (SMD−0.25; 95%CI−0.41–−0.10) and maternal weight gain (SMD−0.61; 95%CI−0.86–−0.35) compared with the insulin group. Network meta-analysis suggested that metformin had the highest probability of successfully controlling glycemia and preventing neonatal complications.Conclusions: The present meta-analysis suggests that metformin may be as effective as insulin for glycemic control and is the most promising drug for the prevention of neonatal and maternal complications.
Dysbiosis of Gut Microbiota and Its Relationship with the Regulatory T&nbsp;Cells&nbsp;in Patients with Aplastic&nbsp;Anemia&nbsp;
Authors: Ren Mengxiao , Ge Yongqin , Qi Jindan , Xue Shengli , Miao Miao , Wu Depei , Huang Yuhui , Wang Xiaohua 
Published: January 2021

Abstract
Background: The characteristics of gut microbiota (GM) and its relationship with the Regulatory T Cells (Treg) remains unclear in patients with aplastic anemia (AA). Methods: This study was a cross-sectional survey which included 12 AA patients consisted of 6 with severity aplastic anemia (SAA) and 6 with non-severity aplastic anemia (NSAA) and 6 healthy participants. The GM and its relationship with the Treg cells of AA patients were analyzed. Results: The results showed that the presence of compositional differences in the GM structure between the AA and Control groups. The bacterial communities were depleted of Clostridia class (e.g., Lachnospiraceae ND3007, Lachnospiraceae XPB1014, Lachnolostridium, Ruminococcaceae UCG 013 and Butyricicoccus genus) in AA group, especially in SAA group. Inversely, the relative abundance of Lactobacillus and Streptococcus genus from Bacilli class were increased significantly in patients with SAA. The relative abundance of Lachnospiraceae (r=0.663, p=0.029), Clostridiaceae 1 (r=0.619, p=0.042) and Clostridiales vadinBB60 group family (r=0.674, p=0.023) which from Clostridia class, were positively correlated with the Treg cell counts. Conclusion: We speculated that the decrease of some bacteria from Clostridia class may participate in the pathophysiological process of AA through reducing the Treg cell counts. Notwithstanding the low sample size, our data provided some clues that the treatment strategy of AA could start by adjusting the imbalance of GM, increasing Treg cell counts to improve the suppression of bone marrow hematopoiesis.