bluuebunny/crossref_metadata_2025_split huggingface dataset:
Normal form approach to the one-dimensional periodic cubic nonlinear Schrödinger equation in almost critical Fourier-Lebesgue spaces
Authors: Oh Tadahiro , Wang Yuzhao 
Published: June 2021

AbstractIn this paper, we study the one-dimensional cubic nonlinear Schrödinger equation (NLS) on the circle. In particular, we develop a normal form approach to study NLS in almost critical Fourier-Lebesgue spaces. By applying an infinite iteration of normal form reductions introduced by the first author with Z. Guo and S. Kwon (2013), we derive a normal form equation which is equivalent to the renormalized cubic NLS for regular solutions. For rough functions, the normal form equation behaves better than the renormalized cubic NLS, thus providing a further renormalization of the cubic NLS. We then prove that this normal form equation is unconditionally globally well-posed in the Fourier-Lebesgue spaces ℱLp($${\cal F}{L^p}(\mathbb{T})$$

ℱ

L
p

(
T
)

), 1 ≤ p < ∞. By inverting the transformation, we conclude global well-posedness of the renormalized cubic NLS in almost critical Fourier-Lebesgue spaces in a suitable sense. This approach also allows us to prove unconditional uniqueness of the (renormalized) cubic NLS in ℱLp($${\cal F}{L^p}(\mathbb{T})$$

ℱ

L
p

(
T
)

) for $$1 \leq p \leq {3 \over 2}$$

1
≤
p
≤

3
2

.
Why a Virtual Assistant for Moral Enhancement When We Could have a Socrates?
Authors: Lara Francisco 
Published: June 2021

AbstractCan Artificial Intelligence (AI) be more effective than human instruction for the moral enhancement of people? The author argues that it only would be if the use of this technology were aimed at increasing the individual's capacity to reflectively decide for themselves, rather than at directly influencing behaviour. To support this, it is shown how a disregard for personal autonomy, in particular, invalidates the main proposals for applying new technologies, both biomedical and AI-based, to moral enhancement. As an alternative to these proposals, this article proposes a virtual assistant that, through dialogue, neutrality and virtual reality technologies, can teach users to make better moral decisions on their own. The author concludes that, as long as certain precautions are taken in its design, such an assistant could do this better than a human instructor adopting the same educational methodology.
State-organized crime and the killing of wolves in Norway
Authors: Sollund Ragnhild , Goyes David R. 
Published: June 2021

AbstractWhile scholars of state crime and organized crime have frequently explored the intersection of these fields with green criminology, for the most part they have not brought the two together as organized state criminality as a means to explore environmental destruction. Of the few explorations of organized state green crime that do exist, most do not embrace a non-speciesist perspective. In this article, we develop a non-speciesist theory of organized state green crime to explain the Norwegian state-licensed killing of wolves, a phenomenon that we analyze through the use of the conceptideological inertia. Our main argument is that the underlying cultural, political and economic interests that were prioritized up to the 1970s in Norway continue to have a counteracting effect on the protection of large carnivores, which the country committed to as a signatory to the Bern Convention.
68Ga-PSMA-11 PET imaging in patients with ongoing androgen deprivation therapy for advanced prostate cancer
Authors: Fassbind Saskia , Ferraro Daniela A. , Stelmes Jean-Jacques , Fankhauser Christian D. , Guckenberger Matthias , Kaufmann Philipp A. , Eberli Daniel , Burger Irene A. , Kranzbühler Benedikt 
Published: June 2021

Abstract
Purpose
Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET) imaging significantly improved the detection of recurrent prostate cancer (PCa). However, the value of PSMA PET imaging in patients with advanced hormone-sensitive or hormone-resistant PCa is still largely unknown. The aim of this study was to analyze the detection rate and distribution of lesions using PSMA PET imaging in patients with advanced PCa and ongoing androgen deprivation therapy (ADT).

Methods
A total of 84 patients diagnosed with hormone-sensitive or hormone-resistant PCa who underwent 68Ga-PSMA-11 PET/magnetic resonance imaging (MRI) or computer tomography (CT) under ongoing ADT were retrospectively analyzed. We assessed the detection of PSMA-positive lesions overall and for three PSA subgroups (0 to < 1 ng/mL, 1 to < 20 ng/mL and > 20 ng/mL). In addition, PSMA-positive findings were stratified by localization (prostatic fossa, pelvic, para-aortic, mediastinal/supraclavicular and axillary lymph nodes, bone lesions and visceral lesions) and hormone status (hormone-sensitive vs. hormone-resistant). Furthermore, we assessed how many patients would be classified as having oligometastatic disease (≤ 3 lesions) and theoretically qualify for metastasis-directed radiotherapy (MDRT) in a personalized patient management.

Results
We detected PSMA-positive lesions in 94.0% (79 of 84) of all patients. In the three PSA subgroups detection rates of 85.2% (0 to < 1 ng/mL, n = 27), 97.3% (1 to < 20 ng/mL, n = 37) and 100% (> 20 ng/mL, n = 20) were observed, respectively. PSMA-positive visceral metastases were observed only in patients with a PSA > 1 ng/mL. Detection of PSMA-positive lesions did not significantly differ between patients with hormone-sensitive and hormone-resistant PCa. Oligometastatic PCa was detected in 19 of 84 patients (22.6%). Almost all patients, 94.7% (n = 18) would have been eligible for MDRT.

Conclusions
In this study, we observed an overall very high detection rate of 94% using PSMA PET imaging in patients with advanced PCa and ongoing ADT. Even in a majority of patients with very low PSA values < 1 ng/ml PSMA-positive lesions were found.
SABCS 2020: update on triple-negative and metastatic HER2-positive breast cancer
Authors: Bartsch Rupert 
Published: June 2021

SummaryOne year into the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic, the 2020 San Antonio Breast Cancer Symposium (SABCS) was another large congress held in a virtual format. Despite these circumstances, clinically relevant data were presented, and this short review focuses on developments in the fields of triple-negative breast cancer (TNBC) and metastatic HER2-positive breast cancer. A quality-of-life (QoL) analysis from IMPassion031 showed that adding atezolizumab to neoadjuvant chemotherapy was not associated with a detrimental effect on QoL, while the burden of treatment-induced side effects increased with each cycle of neoadjuvant therapy in both treatment arms. KEYNOTE-355 evaluated the addition of pembrolizumab to chemotherapy as first-line treatment in metastatic TNBC (mTNBC); a significant improvement of progression-free survival (PFS) was reported in the pembrolizumab arm. At the 2020 SABCS, results with respect to different chemotherapy backbones were reported and the benefit of pembrolizumab was maintained irrespective of the type of taxane. Disappointingly, the phase III IPATunity130 study could not confirm a PFS improvement with the AKT inhibitor ipatasertib when added to paclitaxel as first-line treatment in mTNBC. A biomarker analysis from the phase III ASCENT study showed that the antibody–drug conjugate sacituzumab govitecan was superior to chemotherapy by investigator’s choice independent of Trop‑2 expression and BRCA mutation status. In HER2-positive breast cancer, the PRECIOUS trial suggested a small albeit significant benefit with reinduction of pertuzumab in later treatment lines in patients progressing on prior dual HER2-blockade in the first- or second-line setting. The HER2-specific tyrosine kinase inhibitor tucatinib when added to trastuzumab and capecitabine was shown to improve PFS and overall survival (OS) over trastuzumab and capecitabine alone in pretreated patients in the randomized HER2CLIMB trial; this benefit was apparently independent of hormone-receptor expression. An update from the DESTINY-Breast01 trial reported a median PFS of 19.4 months with trastuzumab deruxtecan in heavily pretreated patients. Finally, an analysis from the PERTAIN trial with > 6 years median follow-up showed excellent OS in patients with luminal B/HER2-positive receiving first-line trastuzumab/pertuzumab in combination with endocrine therapy suggesting that chemotherapy-free treatment is an option in highly selected patients.
Property changes in materials due to atomic oxygen in the low Earth orbit
Authors: Goto Aki , Umeda Kaori , Yukumatsu Kazuki , Kimoto Yugo 
Published: June 2021

AbstractWe expect satellites at altitude below 300 km, very low Earth orbit (VLEO), making observations of the Earth at optical wavelength with increasingly higher resolution. The density of atomic oxygen (AO) at VLEO is significantly higher than that at LEO; severe degradation of spacecraft materials (polymers) due to the high-flux AO is a serious concern. To clarify VLEO environmental effects on spacecraft materials, we designed the Material Degradation Monitor (MDM) and MDM2 missions. The MDM is a material exposure experiment onboard the Super Low-Altitude Test Satellite (SLATS). It aims to understand reactions and degradation of polymeric materials depending on AO fluence in VLEO. In the MDM, samples of spacecraft material were exposed at altitude of 160–560 km; their degradation behaviors were observed optically by a CCD camera for 1.8 years. The MDM2 is a material exposure experiment onboard the International Space Station (ISS) and aims to correctly understand surface reactions and degradation of the same samples used in the MDM at a given AO fluence. In the MDM2, the samples were exposed at altitude of 400 km for 1 year and then returned to Earth for analysis. Based on the results from both missions, we will help in the molecular design of more-durable materials, and establish design standards for future VLEO satellites. This study aims to quantitatively understand the surface reactions and degradation of the 11 types of thermal control materials exposed on the ISS in the MDM2. Five types of multilayer insulation (MLI) films (three types of Si-containing AO protective materials (a silsesquioxane-(SQ-) containing coated polyimide film, two types of polysiloxane-block polyimide (BSF-30) films), an ITO-coated polyimide film, and a Beta Cloth), and flexible optical solar reflectors (flexible OSRs) were found to have a high durability against erosion by AO. This was determined by measuring their loss of mass and thermo-optical properties. The Ag/Inconel layer’s discoloration and peeling were observed for three types of FEP/Ag films as determined by the Ag layer’s oxidation by AO. Also, X-ray photoelectron spectroscopy (XPS) showed that reactions of the Si-containing materials, the SQ-coated polyimide film and the BSF-30 film, form a layer of silica that protects against AO. Even though the concentration of Si in the SQ-coating is the same or greater than in the BSF-30 film, the amount of the SQ-coating that reacted was larger than that of the BSF-30 film under the same AO fluence. Moreover, the effective ability of the UV-shielding coating, composed of ITO and CeO2 coated onto one of the BSF-30 films, was demonstrated by UV–Vis spectrometry. Its sufficient AO protection was confirmed by mass measurements, XPS analyses, and FE-SEM observations.
Predictive modelling of TBARS changes in the intramuscular lipid fraction of raw ground pork enriched with plant extracts
Authors: Kaczmarek Anna Maria , Muzolf-Panek Małgorzata 
Published: June 2021

AbstractThe aim of the study was to develop and compare the predictive models of lipid oxidation in minced raw pork meat enriched with selected plant extracts (allspice, basil, bay leaf, black seed, cardamom, caraway, cloves, garlic, nutmeg, onion, oregano, rosemary and thyme) by investigation TBARS values changes during storage at different temperatures. Meat samples with extract addition were stored under various temperatures (4, 8, 12, 16, and 20°C). TBARS values changes in samples stored at 12°C were used as external validation dataset. Lipid oxidation was evaluated by the TBARS content. Lipid oxidation increased with storage time and temperature. The dependence of lipid oxidation on temperature was adequately modelled by the Arrhenius and log-logistic equation with high R2coefficients (0.98–0.99). Kinetic models and artificial neural networks (ANNs) were used to build the predictive models. The obtained result demonstrates that both kinetic Arrhenius (R2 = 0.83) and log-logistic (R2 = 0.84) models as well as ANN (R2 = 0.99) model can predict TBARS changes in raw ground pork meat during storage.
Effect of structural differences of pumice on synthesis of pumice-supported nFe0: removal of Cr (VI) from water
Authors: Tural Bilsen , Ertaş Erdal , Güzel Mehmet , Tural Servet 
Published: June 2021

AbstractIn this study, pumice from different regions of Turkey (Diyarbakir, Southeast Turkey and Bitlis, East Turkey) has been supplied and used as supporting material for nanoscale zero-valent iron (nFe0). Native Bitlis pumice (NBP)-supported nanoscale zero-valent iron (BP-nFe0) and native Diyarbakir pumice (NDP)-supported nanoscale zero-value iron (DP-nFe0) were synthesized under the same conditions. Native pumice (NDP, NBP) and pumice-supported nFe0 (DP-nFe0 and BP-nFe0) adsorbents were morphologically and structurally characterized by SEM, EDX, XRF and BET. When using NBP as support material, the iron content of the BP-nFe0 increased 1.9-fold from 1.99 to 3.83%. However, iron content of NDP (2.08%) increased approximately 29 times after it is used as a support material in synthesis of DP-nFe0 (60%). The removal potential of native pumice (NBP and NDP) and iron-modified pumice (BP-nFe0 and DP-nFe0) samples was investigated to remove Cr(VI) ions. The parameters of solution pH, initial metal concentration, contact time and the amount of adsorbent in the removal of chromium (VI) ions were investigated. Langmuir, Freundlich, Temkin, Dubinin–Radushkevich and Jovanovic isotherm models were used to evaluate the adsorption equilibrium data. The equilibrium adsorption was found so as to be well described by the Langmuir isotherm model for all the adsorbents studied. The maximum adsorption capacity of Cr(VI) ions for NDP, NBP, DP-nFe0 and BP-nFe0 was 10.82, 14.30, 161.29 and 17.39 mg/g, respectively. The rate of Cr(VI) removal was subjected to kinetic analysis using pseudo-first-order, pseudo-second-order, intraparticle diffusion and Elovich models. Kinetic studies suggest that adsorption of NDP, NBP, DP-nFe0 and BP-nFe0 described more favorably by the pseudo-second-order kinetic model. The results showed that NDP is a much better support material for nFe0 when compared to NBP.
Learning curve and global benchmark values of laparoscopic sleeve gastrectomy: results of first 100 cases of a newly trained surgeon in an Italian center of excellence
Authors: Vitiello Antonio , Berardi Giovanna , Velotti Nunzio , Schiavone Vincenzo , Musella Mario 
Published: June 2021

AbstractTo evaluate whether the learning curve for sleeve gastrectomy could be completed after 50 cases. First 100 patients undergoing LSG under a newly trained laparoscopic surgeon were included in this study and divided into two groups of 50 consecutive patients each. Perioperative outcomes were compared to recently introduced global benchmarks. Short-term weight loss was calculated as Total Weight Loss Percent (%TWL) and complications were classified in accordance with the Clavien–Dindo classification. CUSUM analysis was performed for operative time and hospital stay. Mean preoperative age and BMI were 41.8 ± 10.3 years and 42.9 ± 5.4 kg/m2, respectively. Demographics and rate of patients with previous surgery were comparable preoperatively in the two groups. Mean operative time was 92.1 ± 19.3 min and hospital stay was 3.4 ± 0.6 days as per our standard protocol of discharge. Uneventful postoperative course was recorded in 93% of patients and only one case of staple line leak was registered in the first 50 cases (group 1). No statistical difference in BMI and %TWL was found between the two groups at any time of follow-up. Comparison between two groups showed a significant reduction in hospital stay and operative time after the first 50 LSGs (p < 0.05). LSG can be performed by newly trained surgeons proctored by senior tutors. At least 50 cases are needed to meet global benchmark cut-offs and few more cases may be required to reach the plateau of the learning curve.
Dual-Wavelength Continuous Wave Photoacoustic Doppler Flow Measurement
Authors: Zhao Hongcai , Liu Yanbin , Farooq Tayyab , Fang Hui 
Published: June 2021

AbstractPhotoacoustic Doppler flow measurement based on continuous wave laser excitation owns the merit of clearly presenting the Doppler power spectra. Extending this technique to dual wavelengths can gain the spectral information of the flow sample extra to the flow speed information. An experimental system with two laser diodes respectively operated at 405 nm and 660 nm wavelengths is built and the flow measurement with black and red dyed polystyrene beads is performed. The measured Doppler power spectra can vividly reflect the flow speed, the flow direction, as well as the bead color. Since it is straightforward to further apply the same principle to multiple wavelengths, we can expect this type of spectroscopic photoacoustic Doppler flow measurement will be developed in the near future which will be very useful for studying the metabolism of the slowly moving red blood cell inside microvessels.
Fractional glassy relaxation and convolution modules of distributions
Authors: Kleiner T. , Hilfer R. 
Published: June 2021

AbstractSolving fractional relaxation equations requires precisely characterized domains of definition for applications of fractional differential and integral operators. Determining these domains has been a longstanding problem. Applications in physics and engineering typically require extension from domains of functions to domains of distributions. In this work convolution modules are constructed for given sets of distributions that generate distributional convolution algebras. Convolutional inversion of fractional equations leads to a broad class of multinomial Mittag-Leffler type distributions. A comprehensive asymptotic analysis of these is carried out. Combined with the module construction the asymptotic analysis yields domains of distributions, that guarantee existence and uniqueness of solutions to fractional differential equations. The mathematical results are applied to anomalous dielectric relaxation in glasses. An analytic expression for the frequency dependent dielectric susceptibility is applied to broadband spectra of glycerol. This application reveals a temperature independent and universal dynamical scaling exponent.
Was ist schwierig am Modellieren? Identifikation und Beschreibung von Hindernissen in Modellierungsprozessen von Lehramtsstudierenden naturwissenschaftlicher Fächer
Authors: Göhner Maximilian , Krell Moritz 
Published: June 2021

ZusammenfassungDie Entwicklung von Modellkompetenz im naturwissenschaftlichen Unterricht kann potenziell zur Erreichung vielfältiger Ziele naturwissenschaftlicher Bildung beitragen. Studien deuten allerdings darauf hin, dass Modellierungsprozesse, in denen Modelle kritisch reflektiert oder als Werkzeuge zur Erkenntnisgewinnung eingesetzt werden, im Unterricht eher selten umgesetzt werden und dass Lehrkräfte in Bezug auf Fähigkeiten des naturwissenschaftlichen Modellierens weitere Förderung benötigen. Das Ziel der vorliegenden Studie ist die Identifikation und Beschreibung von Hindernissen, die in Modellierungsprozessen von Lehramtsstudierenden naturwissenschaftlicher Fächer auftreten. Hierzu wurden die Modellierungsprozesse von 36 Lehramtsstudierenden naturwissenschaftlicher Fächer bei der Untersuchung einer Blackbox qualitativ-inhaltsanalytisch ausgewertet. Es konnten 13 verschiedene Hinderniskategorien identifiziert und beschrieben werden. Die identifizierten Hinderniskategorien weisen teils Parallelen zum Experimentieren und naturwissenschaftlichen Arbeiten allgemein auf: Spezifische Hinderniskategorien für das Modellieren ergeben sich dagegen beim Umgang mit Analogien und Erfahrungen und treten vor allem beim Testen des entwickelten Modells auf. Basierend auf vorherigen Arbeiten wurden zudem die Modellierungsprozesse der Lehramtsstudierenden analysiert und sechs typischen Modellierungsstrategien zugeordnet. Es scheint kein eindeutiger Zusammenhang zwischen den identifizierten Hindernissen und den Modellierungsstrategien vorzuliegen, da ProbandInnen, die ähnlichen Hindernissen begegnen, sich hinsichtlich ihrer Modellierungsstrategien teils deutlich unterscheiden. Es wird diskutiert, inwiefern die identifizierten Hinderniskategorien für die weitere Entwicklung von Diagnoseinstrumenten und zur gezielten Planung von Förderangeboten genutzt werden können.
Scalable kernel-based SVM classification algorithm on imbalance air quality data for proficient healthcare
Authors: Ketu Shwet , Mishra Pramod Kumar 
Published: June 2021

AbstractIn the last decade, we have seen drastic changes in the air pollution level, which has become a critical environmental issue. It should be handled carefully towards making the solutions for proficient healthcare. Reducing the impact of air pollution on human health is possible only if the data is correctly classified. In numerous classification problems, we are facing the class imbalance issue. Learning from imbalanced data is always a challenging task for researchers, and from time to time, possible solutions have been developed by researchers. In this paper, we are focused on dealing with the imbalanced class distribution in a way that the classification algorithm will not compromise its performance. The proposed algorithm is based on the concept of the adjusting kernel scaling (AKS) method to deal with the multi-class imbalanced dataset. The kernel function's selection has been evaluated with the help of weighting criteria and the chi-square test. All the experimental evaluation has been performed on sensor-based Indian Central Pollution Control Board (CPCB) dataset. The proposed algorithm with the highest accuracy of 99.66% wins the race among all the classification algorithms i.e. Adaboost (59.72%), Multi-Layer Perceptron (95.71%), GaussianNB (80.87%), and SVM (96.92). The results of the proposed algorithm are also better than the existing literature methods. It is also clear from these results that our proposed algorithm is efficient for dealing with class imbalance problems along with enhanced performance. Thus, accurate classification of air quality through our proposed algorithm will be useful for improving the existing preventive policies and will also help in enhancing the capabilities of effective emergency response in the worst pollution situation.