bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Nutrient removal effectivity of seaweeds as biofilter and water pollution control in hybrid grouper aquaculture wastewater at low salinity
Authors: Adharini Ratih Ida , Murwantoko Murwantoko , Probosunu Namastra , Setiawan Riza Yuliratno , Satriyo Tony Budi 
Published: February 2021

Abstract
This research aims to determine the performance and nutrient removal effectivity of seaweeds species, namely Ulva fasciata., Sargassum illicifolium, Gelidium sp., and Dictyota sp. as a biofilter in hybrid grouper aquaculture wastewater at low salinity (14-17 ppt). This study used a Completely Randomized Design with 3 replications. The statistical analysis was carried out by Analysis of Variance continued with the Least Significance Difference test, and the Kruskal-Walis test with the Mann-Whitney analysis, and T-test with a confidence level of 95%. The concentrations of ammonia, nitrate, phosphate, and water quality parameters were observed every 4 days. The seaweeds removal of N and P in water, and Specific Growth Rate were also observed. The results showed that U. fasciata was able to remove or reduce ammonia by 75.95% and nitrate by 79.53%, which were the highest compared to other treatments, while Dictyota sp. was able to reduce the highest phosphate by 87.5% for 20 days. The highest SGR was achieved by U. fasciata at 1.91 %day -1 . The highest N content uptake by seaweeds was 104.4%, and the total P of 182.3% occurred in U. fasciata . Overall, U. fasciata has the highest performance and effectiveness as a biofilter that is able to reduce nutrient waste in low-salinity from grouper aquaculture, for re-circulation or before being discharged into the environment to reduce eutrophication and Harmful Algal Blooms (HABs) in open water system. The highest growth rate of U. fasciata can be used as food with highly nutritional and economical value.
Keywords : seaweeds, biofilter, hybrid grouper, wastewater, nutrient removal
A case of thyroid storm caused by Graves' disease misdiagnosed as panic attack due to panic disorder
Authors: Yasuda Manabu , Kumakura Jun , Kiyonori Oka , Fukuda Kazuhito 
Published: February 2021

Abstract
Background Graves' disease is characterized by hyperthyroidism and the symptoms of Graves' disease often overlap with those of panic disorder, which may make it difficult to distinguish between the two conditions.In this report, we describe how proper diagnosis of thyroid disease in patients with mental illness can lead to appropriate treatment.Case presentation We encountered a 34-year-old woman in whom thyroid crisis from Graves’ disease was misdiagnosed as panic attack. The patient was being managed as a case of panic disorder and bipolar disorder in a psychiatric outpatient setting. About 6 months before presentation, she had lost about 16 kg in weight, and a month before presentation, she developed several unpleasant symptoms as her condition worsened. Several weeks before, she had severe palpitations, tachycardia, and discomfort in her throat. She became unable to eat solids and ate only yogurt and gelatin and felt difficult to take psychiatric drugs.A day on the Sunday morning, she visited our department of emergency outpatient with severe nausea. Examination revealed proptosis, and so thyroid function tests were requested in addition to routine blood tests. There was no improvement in her condition, and she returned to hospital in the early hours of the next morning. Based on her symptoms, she was diagnosed as having panic attacks due to panic disorder and was given diazepam injection and allowed to go home. There was no suspicion of Graves' disease.Later that day, the thyroid function test results became available and thyroid storm was suspected. The endocrinology department was consulted immediately and she was referred and hospitalized the next day. During hospitalization, she was treated with steroid and radioisotope therapy, and was discharged from hospital in three weeks. Conclusion Psychiatrists and doctors engaged in psychosomatic medicine need to consider the possibility of thyroid disease as a differential diagnosis of panic disorder. It is necessary to check thyroid function at the initial examination when a patient presents with symptoms of severe panic attack.
Seasonal variability of ocean circulation near the Dotson Ice Shelf, Antarctica
Authors: Yang Hee Won , Kim Tae-Wan , Dutrieux Pierre , Wahlin A. K. , Jenkins Adrian , Ha Ho Kyung , Kim Chang-Sin , Cho Kyoung-Ho , Park Taewook , Lee SangHoon , Cho Yang-Ki 
Published: February 2021

Abstract
Recent rapid thinning of West Antarctic ice shelves are believed to be caused by intrusions of warm deep water that induce basal melting and seaward meltwater export. Dotson Ice Shelf has a high basal melt rate due to southward ocean heat transport in the Dotson-Getz Trough. We deployed three bottom-moored instrument arrays along the ice shelf calving front, obtaining continuous records of temperature, salinity, and current velocity throughout 2014 and 2015. Southward deep water velocities were highest along the eastern channel slope, while northward outflows of freshened ice shelf meltwater spread at intermediate depth above the western slope. Inflow warm water along the eastern slope into the sub-Dotson cavity reached a maximum of 182 MW m− 1 in Summer, 3.5 times larger than the autumn/winter values of 51 MW m− 1. The inflow correlated with the local ocean surface stress curl. At the western slope meltwater outflows were strongest during autumn and weakest in spring, following the warm influx along the eastern slope with a ~ 2–3 months delay. Ocean circulation near Dotson Ice Shelf, affected by sea ice distribution and wind, appears to be a significant control on the inflow of warm water and subsequent ice shelf melting on seasonal time-scales.
Identification of Two-Dimensional Layered Dielectrics from
First Principles
Authors: Osanloo Mehrdad Rostami , de Put Maarten Van , Saadat Ali , Vandenberghe William 
Published: February 2021

Abstract
Two-dimensional (2D) van der Waals (vdW) materials promise ideal electrostatic control of charge carrier flow in a channel free of surface roughness or defects. To realize this ideal, good vdW dielectrics are needed in addition to the well explored channel materials. We study the dielectric properties of 32 easily exfoliable vdW materials using first principles methods. Specifically, we calculate the static and optical dielectric response of the monolayer and bulk form. In monolayers, we discover a strong out-of-plane response in GeClF (10.99), LaOBr (13.20), LaOCl (55.80) and PbClF (15.17), while the in-plane dielectric response is strong in BiOCl, PbClF, and TlF, ranging from 64.86 to 98.37. To assess their potential as gate dielectrics, we calculate the bandgap and electron affinity, and estimate the leakage current through the dielectric. We discover seven monolayer 2D dielectrics that promise to outperform bulk HfO2: LaOBr, LaOCl, CaHI, SrBrF, SrHBr, SrHI, and TlF with lower leakage currents at a significantly reduced equivalent oxide thickness. Of these, LaOBr and LaOCl are the most promising and our findings motivate the growth and exfoliation of rare-earth oxyhalides for their use as vdW dielectrics on vdW transistor channel materials.
First-aid Fast Track Channel in Rescuing Critically Ill Children With Airway Foreign Body: Our Clinical Experience
Authors: Chen Yong-chao , Xian Zhi-xiong , Han Sai-hong , Li Lan , Teng Yi-shu 
Published: February 2021

Abstract
Objective To explore the role of First-aid Fast Track channel in rescuing children with airway foreign body, and to analyze and summarize the experience and lessons of First-aid Fast Track channel in rescuing airway foreign body in critical condition. Methods Clinical data of 21 cases of First-aid Fast Track channel rescue admitted to our hospital from January 2017 to December 2020were retrospectively collected, including 12 males and 9 females, aged 9-18 months, with an average age of 15 months and a history of 1-72 hours. Follow-up medical history showed that all 21 children had a history of significant foreign body cough. Results 21 cases of airway foreign body were successfully removed without second operation. Twenty-one critically ill children were intubated into PICU after surgery. Two of the children had a history of asphyxia rescue in a foreign hospital. After endotracheal intubation and cardiopulmonary resuscitation, the ambulance was sent to our hospital. Although the foreign body was removed, the patient's family gave up the treatment because the brain hypoxia lasted too long and the deep coma could not be recovered. Conclusion First-aid Fast Track channel of airway foreign body is the cooperation of otolaryngology, anesthesiology, ICU, emergency room and other departments, which has won valuable time for rescue, highlighted the purpose of rescue, improved the success rate of rescue and the quality of life of children, and is of great value for the treatment of critical tracheal foreign body.
DNA Hypermethylation of a panel of genes as an urinary biomarker for bladder cancer diagnosis
Authors: Georgopoulos Petros , Papaioannou Maria , Markopoulou Soultana , Fragou Aikaterini , Kouvatseas George , Apostolidis Apostolos 
Published: February 2021

Abstract
PurposeThe aim of this study was to explore the diagnostic potential of a panel of five hypermethylated gene promoters in bladder cancer. Individuals with primary BCa and control individuals matching the gender, age and smoking status of the cancer patients were recruited. DNA methylation was assessed for the gene promoters of RASSF1, RARβ, DAPK, hTERT and APC in urine samples collected by spontaneous urination. Fifty patients and 35 healthy controls were recruited, with average age of 70.26 years and average smoking status of 44.78 pack-years. In the BCa group, DNA methylation was detected in 27(61.4%) samples. RASSF1 was methylated in 52.2% of samples. Only 3(13.6%) samples from the control group were methylated, all in the RASSF1 gene promoter. The specificity and sensitivity of this panel of genes to diagnose BCa was 86% and 61% respectively. The RASSF1 gene could diagnose BCa with specificity 86.4% and sensitivity 52.3%. Promoter DNA methylation of this panel of five genes could be further investigated as urine biomarker for the diagnosis of BCa. The RASSF1 could be a single candidate biomarker for predicting BCa patients versus controls. Studies are required in order to develop a geographically adjusted diagnostic biomarker for BCa.Trial registration: ACTRN12620000258954
Risk Factors for Overweight and Obesity Among Women of Reproductive Age in Dar Es Salaam, Tanzania
Authors: Mosha Dominic , Paulo Heavenlight A , Mwanyika-Sando Mary , Mboya Innocent B , Madzorera Isabel , Leyna Germana , Msuya Sia Emmanuel , Bärnighausen Till , Killewo Japhet , Fawzi Wafaie 
Published: February 2021

Abstract
Background: Overweight and obesity have increased considerably in low- and middle-income countries over the past few decades, particularly among women of reproductive age. This study assessed the role of physical activity and nutrient intake in overweight and obesity among women in Dar es Salaam, Tanzania.Methods: We conducted a cross-sectional survey among 1,004 women aged 15 - 49 years in the Dar es Salaam Urban Cohort Study (DUCS) from September 2018. Dietary intake was assessed using a food frequency questionnaire (FFQ). Physical activity was assessed using the Global Physical Activity Questionnaire (GPAQ) using metabolic equivalent tasks (MET). Modified poison regression models were used to evaluate associations between physical activity and nutrient intake with overweight/obesity in women, controlling for energy and other factors.Results: The mean (±SD) age of study women was 30.2 (±8.1) years. Prevalence of overweight and obesity was high (50.4%), and underweight was 8.6%. Risk of overweight/obesity was higher among older women (35 – 49 vs. 15 – 24 years: PR 1.59; 95% CI: 1.30 – 1.95); women of higher wealth status (PR 1.24; 95% CI: 1.07–1.43); and informally employed and married women. Attaining moderate to high physical activity (≥600 MET) was inversely associated with overweight/obesity (PR 0.79; 95% CI: 0.63 – 0.99). Dietary sugar intake (PR 1.27; 95% CI: 1.03 – 1.58) was associated with increased risk, and fish and poultry consumption (PR 0.78; 95% CI: 0.61 – 0.99) with lower risk of overweight/obesity.Conclusion: Lifestyle (low physical activity and high sugar intake), and socio-demographic (age, wealth status, informal employment and married status) factors were associated with increased risk, and, fish/poultry consumption with lower risk of overweight/obesity. Given its potential for increasing diet-related chronic diseases and poor maternal and child nutrition outcomes, overweight/obesity among Tanzanian women should be addressed through feasible, and effective physical activity and dietary interventions.
Disorganization of Intercalated Discs in Dilated Cardiomyopathy
Authors: Ito Yukinobu , Yoshida Makoto , Masuda Hirotake , Maeda Daichi , Kudo-Asabe Yukitsugu , Umakoshi Michinobu , Nanjo Hiroshi , Goto Akiteru 
Published: February 2021

Abstract
Dilated cardiomyopathy (DCM) is a primary myocardial disease, the pathology of which is left ventricular or biventricular dilation and impaired myocardial contractility. The clinical and pathological diagnosis of DCM is difficult, and other cardiac diseases must be ruled out. Several studies have reported pathological findings that are characteristic of DCM, including cardiomyocyte atrophy, nuclear pleomorphism, and interstitial fibrosis, but none of these findings are DCM-specific. In this study, we examined the morphological differences in ICDs between three groups of patients, a DCM group, a chronic heart failure group, and a control group. A total of 21 autopsy cases, including five DCM cases, eight CHF cases and eight control cases, were retrieved from the archives of the Department of Pathology at Akita University, Japan. The morphological differences were examined using multiple methods: macroscopic examination, light microscopy, immunohistochemistry, electron microscopy, and gene expression analyses. We observed disorganized intercalated discs (ICDs), clearly illustrated by N-cadherin immunostaining in the DCM group. “Reduction of N-cadherin immunostaining intensity” and “ICD scattering” was DCM-specific. The results suggest that disorganized ICDs contribute to the development of DCM, and that N-cadherin immunostaining is useful for determining the presence of disorganized ICDs and for the pathological diagnosis of DCM.
Glomerular Function in Relation to Fine Airborne Particulate Matter in a Representative Population Sample
Authors: Feng Yingmei , Thijs Lutgarde , Zhang Zhen-Yu , Bijnens Esmee M. , Yang Wen-Yi , Wei Fang-Fei , Janssen Bram G. , Nawrot Tim S , Staessen Jan A. 
Published: February 2021

Abstract
Whereas the adverse impact of fine particulate matter on coronary heart disease and respiratory disorders has been clarified, its influence on glomerular function is not well defined in population studies. Serum creatinine levels were quantified in 820 randomly recruited people (50.7% women; mean age 51.1 years). Among them, 653 participants were followed up for a median of 4.8 years. Using multivariable-adjusted mixed model, eGFR (or serum creatinine) both at baseline and follow-up were regressed against long term residential black carbon (BC) or PM2.5 (particles with an aerodynamic diameter ≤2.5 µm). In longitudinal analysis, the percent change in eGFR was regressed against long term residential exposure to BC or PM2.5. eGFR averaged 80.9 (SD 16.4) mL/min/1.73m2 and median long term PM2.5 and black carbon amounted 13.1 (SD 0.92) and 1.10 (SD 0.19) µg/m³, respectively. In multivariable-adjusted cross-sectional analyses, eGFR was unrelated to BC and PM2.5 (P ≥ 0.59). During follow-up, eGFR decreased on average by 1.9 mL/min/1.73m2 (95% confidence interval: 1.0-2.8). The percentage decline in eGFR was not significantly associated with either BC or PM2.5 (P ≥ 0.75). In conclusion, long-term residential exposure to PM2.5 and black carbon is not associated with eGFR decline in predominantly healthy people drawn from a general semirural population.
The Effect of National Weekly COVID-19 Screening Testing of All Workers in Long-Term Care Facilities: a Decrease in Mortality
Authors: Maimon Nimrod , Maimon Michal , Hassan Lior , Grotto Itamar , Abu-Fraiha Yasmeen , Robinson-Geva Shahar , Uzan Limor Gortzak , Goldin Sivam , Novack Victor 
Published: February 2021

Abstract
Background Outbreaks of Coronavirus 2019 (COVID-19) in Long-Term Care Facilities (LTCFs) have resulted mainly from disease transmission by asymptomatic health care workers (HCW's). It is not known whether routine COVID-19 screening tests carried out on HCW's would reduce mortality of LTCF residents. Since mid-July 2020, the Israeli national LTCF defense program – "Senior Shield" - has used weekly COVID-19 PCR tests on all LTCF employees.Methods A nationwide, government funded, screening program on all LTCF personnel for four months during the second COVID-19 wave. We evaluated differences between the two waves in the national LTCF's system with regard to hospitalizations and mortality. Estimation of national health system predicted outcomes, in the absence of this weekly screening plan, was calculated.Results COVID-19 tests were taken weekly in all 1,107 LTCFs which includes 62,159 HCWs and 100,046 residents. A median of 55,282 (range – 16,249) tests were performed each week. Turnaround time from sampling to result was less than 24 hours in 95% of tests. Compared to the first wave, in which 45.3% of national mortality was attributed to the LTCF's, the second wave saw a 33.8% reduction in this mortality ratio. Estimation of national health system outcomes during the second wave showed that the activation of the screening program reduced hospital load by 35% and prevented 30% of national mortality from COVID-19.Conclusions Routine weekly COVID-19 PCR testing of all LTCF employees may reduce national hospitalizations and mortality.
Pregnancy Outcomes in Women Affected by Fetal Alpha-thalassemia: A Case Control Study
Authors: Li Jiangheng , Yan Jingli , Huang Yongquan , Wei Jinlu , Xie Bingyan , Jiang Wu , Zhu Maoling 
Published: February 2021

Abstract
To evaluate the possible associations between fetal α-thalassemia and risk of adverse pregnancy outcomes using a provincial woman-child health service information database in China. This was a case control study (N=438,747) in which we compared all singleton pregnancies of women with or without the α-thalassemia trait from May 2016 to May 2020, and where women with the trait were further allocated to a normal fetal group, a group of fetuses with the α-thalassemia trait, and a fetal group with hemoglobin H (HbH) disease according to the results of fetal DNA analysis. With thalassemic women whose fetuses were normal as the reference, fetuses in the HbH disease group showed a higher increase in the odds of Apgar scores being <7 at 1 minute (adjusted odds ratio [aOR], 2.79; 1.03–7.59) and 5 minutes (aOR, 4.56; 1.07–19.40). With non-thalassemic women as the reference, these trends were more obvious (aOR, 4.83; 2.55–9.16; aOR, 6.24; 2.75–14.18, respectively); whereas the normal fetal group was more likely to be diagnosed with postpartum hemorrhage (aOR, 1.66; 1.10–2.50). In addition, fetal HbH disease and gestational age were two independent factors influencing low Apgar scores, and their combination reflected medium accuracy in Apgar predictions.
What Is the Impact of Distraction Osteogenesis on the Upper Airway of Hemifacial Microsomia Patient With OSA: a Case Report
Authors: Wang Rongyang , Xu Shixing , Yang Ruimei 
Published: February 2021

Abstract
Background: Current researches about hemifacial microsomia (HFM) patients after distraction osteogenesis (DO) most emphasize the morphologic changes. This case report shows the outcome of DO on the upper airway of a HFM patient with obstructive sleep apnea (OSA) based on the use of computational fluid dynamics (CFD).Case presentation: A boy of 11-year-old was diagnosed as HFM with OSA, and underwent unilateral DO. Polysomnography and CT scans were performed before and six months after treatment. After DO, lowest blood oxygen saturation increased from 81% to 95% and apnea and hypopnea index decreased from 6.4 events/hour to 1.2 events/hour. The oropharynx and nasopharynx were obviously expanded. We observed apparently increased average pressure, decreased average velocity and pressure drop in all cross-sections, and largely decreased airflow resistance and maximum velocity entirely in the airway.Conclusions: The results suggest that DO might be effective for the treament of OSA by expanding the upper airway and reducing the resistance of inspiration.
Budget Impact Analysis of Surfactant Therapy for Bronchiolitis In Critically Ill Infants: The Colombian National Health System Perspective
Authors: buendia jefferson , Patiño Diana Guerrero 
Published: February 2021

Abstract
BACKGROUND: Exogen surfactant in mechanically ventilated infants decreased duration of stay in the intensive care unit and had favorable effects on oxygenation and carbon dioxide removal. This study aimed to evaluate the budget impact of surfactant therapy for bronchiolitis in critically ill infants in Colombia.METHODS: Budget impact analysis was performed to estimate the economic impact of surfactant therapy (ST) for the treatment of infants with a diagnosis of bronchiolitis, requiring mechanical ventilation. The analysis considered a 4-year time horizon and Colombian National Health System perspective. The model estimated drug costs associated with current scenario using humidified oxygen or adrenaline nebulization , and new scenario adding exogen surfactant. The size of the target population was calculated using epidemiological national data. Univariate one-way sensitivity analyses and scenario analyses were performed.RESULTS: In the base-case analysis the 4-year costs associated to ST and no-ST were estimated to be US$ 55.188.132 and US$ 55.972.082 respectively, indicating savings for Colombian National Health equal to US% 783.950 if ST is adopted for the routine management of patients with bronchiolitis requiring mechanical ventilation. Results were consistent at variation of most of the model’s parameters; only in case of increases of drug cost of surfactant and daily cost or length of stay in pediatric intensive unit , the savings are reducedCONCLUSION: ST was cost-saving in emergency settings for treating infants with severe bronchiolitis requiring mechanical ventilation. This shift in treatment approach proved to be economically favorable in the Colombian context.