bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eugenol modulates genomic methylation and inactivates breast cancer‐associated fibroblasts through E2F1‐dependent downregulation of DNMT1/DNMT3A
Authors: Al‐Kharashi Layla A. , Bakheet Tala , AlHarbi Wejdan A. , Al‐Moghrabi Nisreen , Aboussekhra Abdelilah 
Published: September 2021

AbstractActive cancer‐associated fibroblasts (CAFs) are major components of the tumor microenvironment, which promote carcinogenesis and modulate response to therapy. Therefore, targeting these cells or reducing their paracrine pro‐carcinogenic effects could be of great therapeutic value. To this end, we sought to investigate the effect of eugenol, a natural phenolic molecule, on active breast CAFs. We have shown that decitabine (5‐Aza‐2′‐deoxycytidine, DAC) and eugenol inhibit the expression of the DNA methyltransferase genes DNMT1 and DNMT3A at both the protein and mRNA levels in breast CAF cells. While the effect of eugenol was persistent, DAC had only a transient inhibitory effect on the mRNA level of both DNMT genes. Furthermore, eugenol and DAC suppressed the invasive/migratory and proliferative potential of CAF cells as well as their paracrine pro‐carcinogenic effects both in vitro and in humanized orthotopic tumor xenografts. Interestingly, these inhibitory effects of decitabine and eugenol were mediated through E2F1 downregulation. Indeed, ectopic expression of E2F1 upregulated both genes and attenuated the effects of eugenol. Additionally, we provide clear evidence that eugenol, like DAC, strongly modulates the methylation pattern in active CAF cells, through methylating several oncogenes and demethylating various important tumor suppressor genes, which affected their mRNA expression levels. Importantly, the E2F1 promoter was also hypermethylated and the gene downregulated in response to eugenol. Together, these findings show that the active features of breast CAF cells can be normalized through eugenol‐dependent targeting of DNMT1/DNMT3A and the consequent modulation in gene methylation.
Applications of medicinal chemistry for drug discovery against Acanthamoeba infections
Authors: Ahmed Usman , Anwar Ayaz , Ong Seng‐Kai , Anwar Areeba , Khan Naveed Ahmed 
Published: September 2021

AbstractAcanthamoeba is a genus of free‐living amoebae, pervasively found in the environment. Most of its pathogenic species are the causative agent of sight‐threatening Acanthamoeba keratitis and fatal granulomatous amoebic encephalitis. Despite the advancements in the field of chemotherapy, treating Acanthamoeba infections is still challenging due to incomplete knowledge of the complicated pathophysiology. In case of infection, the treatment regimen for the patients is often ineffective due to delayed diagnosis, poor specificity, and side‐effects. Besides the resistance of Acanthamoeba cysts to most of the drugs, the recurrence of infection further complicates the recovery. Thus, it is necessary to develop an effective treatment which can eradicate these rare, but serious infections. Based on various computational and in vitro studies, it has been established that the synthetic scaffolds such as heterocyclic compounds may act as potential drug leads for the development of antiamoebic drugs. In this review, we report different classes of synthetic compounds especially heterocyclic compounds which have shown promising results against Acanthamoeba. Moreover, the antiamoebic activities of synthetic compounds with their possible mode of actions against Acanthamoeba, have been summarized and discussed in this review.
Recommendations for photoprotection of parenteral nutrition for premature infants: An ASPEN position paper
Authors: Robinson Daniel T. , Ayers Phil , Fleming Barbara , Gura Kathleen M. , Gutsul Liliia , Michalski Austin , Holcombe Beverly , Sacks Gordon S. 
Published: September 2021

AbstractAlthough crucial in improving health outcomes in the preterm infants, parenteral nutrition (PN) is not without risk, especially if handled improperly. A growing body of evidence suggests that components of PN admixtures, including lipid injectable emulsions (ILEs), are susceptible to degradation, including oxidation when exposed to light (ie, photo‐oxidation), resulting in the production of reactive oxygen species. Infants, especially those born preterm, are considered more susceptible to consequences of oxidative stress than children and adults. Oxidative stress is associated with bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, and intestinal failure–associated liver disease. The American Society for Parenteral and Enteral Nutrition (ASPEN) assembled a working group to provide recommendations on clinical practice surrounding photoprotection of PN.This Position Paper reviews the scientific literature on the formation of quantifiable peroxides and other degradation products when PN admixtures and ILEs are exposed to light and reports adverse clinical outcomes in premature infants exposed to PN. Recommendations for photoprotection of PN admixtures and ILEs are provided, as well as the challenges in achieving complete photoprotection with the equipment, supplies, and materials currently available in the US. ASPEN and the authors understand that the full implementation of complete photoprotection may not currently be feasible given current product availability; recommendations provided in this paper serve to represent the goal to which to strive as well as to highlight the importance of product availability to achieve these practices. This paper has been approved by the ASPEN Board of Directors.
Comparative efficacy of non‐pharmacological interventions on behavioural and psychological symptoms in elders with dementia: A network meta‐analysis
Authors: Li Wenjie , Xu Xiaofeng , Wu Fen , Ni Yuanyuan , Lan Jun , Hu Xiuying 
Published: September 2021

AbstractAimTo explore the best non‐pharmaceutical interventions for improving the behavioural and psychological symptoms in elders with dementia.DesignBayesian network meta‐analysis.MethodsA comprehensive electronic literature search was performed in five English databases and four Chinese databases to identify relevant randomized controlled trials (RCTs) that were published up to 31 October 2019.ResultsA total of 41 RCTs were included in this network meta‐analysis involving 5 different non‐pharmacological interventions: therapeutic recreation (TC), reminiscence therapy (RT), behaviour therapy (BT), massage therapy (MT) and individualized nursing (IN).The results of network meta‐analysis showed that individualized nursing was the best in improving depression, cognitive function, and activities of daily living of behavioural and psychological symptoms of dementia. Behaviour therapy was the best in improving anxiety symptoms. Reminiscence therapy was the best in improving neuropsychiatric symptoms.
Bond behavior of BFRP bars in concrete under lateral pressure
Authors: Zhao Yushuai , Zhang Yingying , Yu Penghao , Xu Junhao 
Published: September 2021

AbstractBasalt fiber reinforced polymer (BFRP) bars have been widely studied because of its advantages in corrosive environment. At present, the researches on the bond properties of basalt FRP bars mainly focus on the types of bars, bond length and environmental effects. In this paper, the bond properties of 12 mm diameter glass fiber reinforced bars with unilateral and bilateral compressive stresses of 0, 0.15, 0.3, 0.45, 0.6 and 0.75 were studied for revealing the effects of lateral stress. In addition, based on the analysis of the influence of compressive stress on the failure mode, a theoretical analysis model is established. Based on the fitting of ultimate bond strength and slip amount, the bond slip constitutive model of basalt fiber embedded in concrete is proposed, which can work under different compressive stress.
Amorphous High‐Entropy Hydroxides of Tunable Wide Solar Absorption for Solar Water Evaporation
Authors: Pan Jie , Bao Yan , Wang Hao , Lyu Fucong , Liu Lu , Wang Chong , Tang Xinxue , Lu Jian , Li Yang Yang 
Published: September 2021

AbstractThe high‐entropy materials have raised much attention in recent years due to their extraordinary performances in mechanical, catalysis, energy storage fields. Herein, a new type of high‐entropy hydroxides (e.g., NiFeCoMnAl(OH)x) that are amorphous and capable of broad solar absorption is reported. A facile one‐pot co‐precipitation method is employed to synthesize these amorphous high‐entropy hydroxides (a‐HEHOs) under ambient conditions. The a‐HEHOs thus obtained display widely tunable bandgap (e.g., from 2.6 to 1.1 eV) due to their high‐entropy and amorphous characteristics, enabling efficient light absorbance and photothermal conversion in the solar regime. Further solar water evaporation measurements show that the a‐HEHOs delivered a considerable energy conversion efficiency of 55%, comparable to black titanium oxides that are synthesized using more complex and expensive methods.
Is cardiorespiratory disease associated with increased susceptibility of SARS‐CoV‐2 in children?
Authors: Du Berry Cassidy , Saunders Thomas , McMinn Alissa , Tosif Shidan , Shanthikumar Shivanthan , Vandeleur Moya , Harrison Joanne , Burgner David , Ranganathan Sarath , Crawford Nigel , Wurzel Danielle 
Published: September 2021

AbstractBackgroundThere are limited data in pediatric populations evaluating whether chronic cardiorespiratory conditions are associated with increased risk of coronavirus disease 2019 (COVID‐19). We aimed to compare the rates of chronic cardiac and respiratory disease in children testing positive severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2[+]) compared with those testing negative (SARS‐CoV‐2[−]) at our institution.MethodProspective cohort with nested case–control study of all children tested by polymerase chain reaction (PCR) for SARS‐CoV‐2 by nasopharyngeal/oropharyngeal sampling between March and October 2020. Children were identified prospectively via laboratory notification with age and sex‐matching of SARS‐CoV‐2[+] to SARS‐CoV‐2[−] (1:2). Clinical data were extracted from the electronic medical record.ResultsIn total, 179 SARS‐CoV‐2[+] children (44% females, median age 3.5 years, range: 0.1–19.0 years) were matched to 391 SARS‐CoV‐2[−] children (42% female, median age 3.7 years, range: 0.1–18.3 years). The commonest comorbidities showed similar frequencies in the SARS‐CoV‐2[+] and [−] groups: asthma (n = 9, 5% vs. n = 17, 4.4%, p = 0.71), congenital heart disease (n = 6, 3.4% vs. n = 7, 1.8%, p = 0.25) and obstructive sleep apnoea (n = 4, 2.2% vs. n = 10, 2.3%, p = 0.82). In the SARS‐CoV‐2[+] group, the prevalence of symptomatic disease was similar among children with and without cardiorespiratory comorbidities (n = 12, 75% vs. n = 103, 57%, p = 0.35). A high proportion of children hospitalized with SARS‐CoV‐2 infection had cardiac comorbidities (23.8%).ConclusionsIn this single site data set, rates of pre‐existing cardiorespiratory disease were similar in SARS‐CoV‐2[+] and SARS‐CoV‐2[−] children. Rates of symptomatic infection were similar between children with and without cardiorespiratory comorbidity. High rates of comorbid cardiac disease were observed among hospitalized children with COVID‐19 warranting further research to inform vaccine prioritization.
Cost‐utility of as‐needed combination low‐dose budesonide‐formoterol in adolescents mild asthma
Authors: Buendía Jefferson Antonio , Guerrero Patiño Diana , Talamoni Hernan Lucio 
Published: September 2021

AbstractBackgroundPreviously evidence has demonstrated that as‐needed combination low‐dose budesonide‐formoterol reduced the risk of severe exacerbations compared with short‐acting β2‐agonist (SABA) reliever therapy in an adolescent with mild asthma. Concerns as if the extra benefit offered by this drug outweighs the additional cost. This study aimed to evaluate the cost‐effectiveness of as‐needed combination low‐dose budesonide‐formoterol compared with short‐acting β2‐agonist (SABA) reliever therapy in adolescents with mild asthma in Colombia.MethodsA probabilistic Markov model was created to estimate the cost and quality‐adjusted life‐years (QALYs) of patients with mild asthma in Colombia. Total costs and QALYs of low‐dose budesonide‐formoterol compared with short‐acting β2‐agonist (SABA) were calculated over a lifetime horizon. Multiple sensitivity analyses were conducted. Cost‐effectiveness was evaluated at a willingness‐to‐pay value of $19,000.ResultsThe model suggests a potential gain of 0.03 QALYs and per patient per year on low‐dose budesonide‐formoterol. The cost difference per person was US$−4 per patient per year in favor of budesonide‐ formoterol. The position of dominance negates the need to calculate an incremental cost‐effectiveness ratio. In the one‐way and probabilistic sensitivity analyses, our base‐case results were robust to variations of all assumptions and parameters.ConclusionIn conclusion, low‐dose budesonide‐formoterol as a reliever was found to be cost‐effective when added to usual care in adolescents with mild asthma. This evidence should promote economic evaluations in developed and developing countries for the inclusion of new drugs in health insurance plans.
When homologous sequences meet structural decoys: Accurate contact prediction by tFold in CASP14—(tFold for CASP14 contact prediction)
Authors: Shen Tao , Wu Jiaxiang , Lan Haidong , Zheng Liangzhen , Pei Jianguo , Wang Sheng , Liu Wei , Huang Junzhou 
Published: September 2021

AbstractIn this paper, we report our tFold framework's performance on the inter‐residue contact prediction task in the 14th Critical Assessment of protein Structure Prediction (CASP14). Our tFold framework seamlessly combines both homologous sequences and structural decoys under an ultra‐deep network architecture. Squeeze‐excitation and axial attention mechanisms are employed to effectively capture inter‐residue interactions. In CASP14, our best predictor achieves 41.78% in the averaged top‐L precision for long‐range contacts for all the 22 free‐modeling (FM) targets, and ranked 1st among all the 60 participating teams. The tFold web server is now freely available at: https://drug.ai.tencent.com/console/en/tfold.
Gold‐Catalyzed Synthesis of Pyrazolo[1,5‐a]pyridines Regioselectively via 6‐endo‐dig Cyclization
Authors: Sreenivasulu Gottam , Kadiyala Veerabhushanam , Raju Chittala Emmaniel , Sridhar Balasubramanian , Karunakar Galla V. 
Published: September 2021

AbstractAn efficient gold‐catalyzed synthesis of pyrazolo[1,5‐a]pyridines have been developed from pyrazolo substituted propargyl alcohols via 6‐endo‐dig cyclization. In this intramolecular cyclization reaction a new C−N bond was formed regioselectively and good to excellent yields of pyrazolo[1,5‐a]pyridines were obtained in one‐pot.
Bringing Color to Sugars: The Chemical Assembly of Carbohydrates to BODIPY Dyes
Authors: Gomez Ana M. , Lopez J. Cristobal 
Published: September 2021

AbstractThe combination of carbohydrates with BODIPY fluorophores gives rise to a family of BODIPY‐carbohydrate hybrids or glyco‐BODIPYs, which mutually benefit from the encounter. Thus, from the carbohydrates standpoint, glyco‐BODIPYs can be regarded as fluorescent glycoconjugate derivatives with application in imaging techniques, whereas from the fluorophore view the BODIPY‐carbohydrate hybrids benefit from the biocompatibility, water‐solubility, and reduced toxicity, among others, brought about by the sugar moiety. In this Account we have intended to present the collection of available methods for the synthesis of BODIPY‐carbohydrate hybrids, with a focus on the chemical transformations on the BODIPY core.
Introduction: The Personal Is Still Political
Authors: Distiller Natasha 
Published: September 2021

AbstractThis chapter lays out the argument for a psychological humanities, as well as the theoretical framework for ideas developed in the rest of the book. It explains the concept of complicity, which is the term developed in the book to argue against binary thinking as a way of understanding human being and human psychology. The history of psychology as a discipline is outlined, in order to connect it to processes of Western modernity. The chapter defines binary thinking, the notion of self and other, and outlines the relationships between the different branches of psychology.
Well-Intentioned White People and Other Problems with Liberalism
Authors: Distiller Natasha 
Published: September 2021

AbstractThis chapter focuses on liberalism and neoliberalism as both constituents and consequences of the emergence of the psy disciplines through specific processes of modernity in the West. It explores the unified Cartesian subject on which psychology initially depended. It addresses American and South African versions of liberalism and their relationship to race. It also addresses the notion of universal humanity and its relation to the idea of complicity, and begins to apply the idea to intersubjective psychology. The chapter also summarizes the place of Freud’s Oedipus complex in this matrix of ideas and history, and the idea of the Western subject that has emerged accordingly, through and for psychology.
Thought Bodies: Gender, Sex, Sexualities
Authors: Distiller Natasha 
Published: September 2021

AbstractThis chapter continues to explore what the theory of complicity brings, this time to gender, sex and sexuality. It offers a history of the emergence of binary gender and its relation to Western modernity as well as to race and other intersectionalities. It explores a complicitous understanding of transgender personhood in and through queer, feminist and psychological discourses. It also applies complicity to the idea of consent in heterosexual relations, and to transnational LGBTQ+ identities and colonial histories, with a focus on South Africa.
Love and Money
Authors: Distiller Natasha 
Published: September 2021

AbstractThis chapter extends the analysis beyond the subjectivities enabled by Enlightenment liberalism to neoliberal millennial subjectivities. It explores how late capitalism interacts with social media. It argues that human connections have become commodified and structuring principles for human being have changed as a result of specific confluences of the historical and psychological forces tracked so far in previous chapters.
The Complicit Therapist
Authors: Distiller Natasha 
Published: September 2021

AbstractThis chapter explores therapeutic modalities that fit with a complicit theory of human being: feminist therapy, Interpersonal Neurobiology, Polyvagal Theory, Internal Family Systems and intersubjectivity. It examines how to be both systems-oriented and work from a depth approach which is an element of complicit thinking. In exploring how to work therapeutically within this frame, the chapter reiterates the importance of a nonbinary understanding of human being, which has been one of the main points argued throughout the book. This, ultimately, is why the psychological humanities is important: It allows for both the art and the science of psychotherapy to co-exist in a nonbinary way. The chapter also addresses another of the ongoing themes of the book, a complicit approach to identity politics, which is connected to a social-justice-oriented psychotherapy practice.
Interpretation of Corporate Acquisition Contracts in Japan: A Legal Transplant through Contract Drafting
Authors: Hoshi Akio 
Published: September 2021

AbstractThis article explores Japanese transactional lawyers’ attempts to transplant American legal practice concerning corporate acquisition contracts into Japan. Despite their extensive efforts to disseminate legal concepts originating from the common law into the Japanese legal community, their transplantation attempts produced somewhat unexpected results by the promoters of the transplant. Faced with unfamiliar drafting styles and legal concepts, Japanese courts interpreted American-style corporate acquisition contracts in accordance with traditional Japanese-style contract interpretation. As a result, attempts by Japanese practitioners at transplantation were incomplete. This incompleteness is attributable to their inattention to the differences in approaches to contract interpretation between Japanese and New York courts. New York's approach is much more formalistic and literal than Japan's. If fully aware, however, they could have filled the gap by using functional substitutes for American techniques of controlling adjudicators’ contract interpretation which would effectively operate under Japanese law. Japan's experience confirms that a widely supported view in comparative law scholarship that transplanted law does not necessarily operate in the recipient jurisdiction as it did in its host jurisdiction is applicable to the transplantation of contract drafting practices.
Leukodystrophy Due to eIF2B Mutations in Adults
Authors: Shivaram Sumanth , Nagappa Madhu , Seshagiri Doniparthi Venkata , Saini Jitender , Govindaraj Periyasamy , Sinha Sanjib , Bindu Parayil Sankaran , Taly Arun B. 
Published: September 2021

ABSTRACT:Vanishing white matter disease (VWMD) due to eIF2B mutations is a common leukodystrophy characterised by childhood onset, autosomal recessive inheritance, and progressive clinical course with episodic worsening. There are no reports of genetically confirmed adult patients from India. We describe the phenotype of two adults with genetically confirmed VWMD and typical radiological findings. Both had spastic ataxia and cognitive and behavioural disturbances. Other neurological features included myoclonic jerks and parkinsonism. At the last follow-up (duration: 2–9 years), one patient was wheelchair-bound. VWMD is rare in adults but should be suspected based on radiological findings and confirmed by eIF2B mutation.
Indigenous Epistemologies of North America
Authors: Allen Barry 
Published: September 2021

AbstractIndigenous cultures of North America confronted a problem of knowledge different from that of canonical European philosophy. The European problem is to identify and overcome obstacles to the perfection of knowledge as science, while the Indigenous problem is to conserve a legacy of practice fused with a territory. Complicating the difference is that one of these traditions violently colonized the other, and with colonization the Indigenous problem changes. The old problem of inter-generational stability cannot be separated from the post-colonial problem of sovereignty in the land where the knowledge makes sense. I differentiate the question of the value of knowledge (Part 1), and its content (Part 2). The qualities these epistemologies favor define what I callceremonial knowledge, that is, knowledge that sustains a ceremonial community. The question of content considers the interdisciplinary research of Indigenous and Traditional Ecological Knowledge, as well as the issue of epistemic decolonization.
Reeb orbits that force topological entropy
Authors: ALVES MARCELO R. R. , PIRNAPASOV ABROR 
Published: September 2021

Abstract
We develop a forcing theory of topological entropy for Reeb flows in dimension three. A transverse link L in a closed contact

$3$

-manifold

$(Y,\xi )$

is said to force topological entropy if

$(Y,\xi )$

admits a Reeb flow with vanishing topological entropy, and every Reeb flow on

$(Y,\xi )$

realizing L as a set of periodic Reeb orbits has positive topological entropy. Our main results establish topological conditions on a transverse link L, which imply that L forces topological entropy. These conditions are formulated in terms of two Floer theoretical invariants: the cylindrical contact homology on the complement of transverse links introduced by Momin [A. Momin. J. Mod. Dyn.5 (2011), 409–472], and the strip Legendrian contact homology on the complement of transverse links, introduced by Alves [M. R. R. Alves. PhD Thesis, Université Libre de Bruxelles, 2014] and further developed here. We then use these results to show that on every closed contact

$3$

-manifold that admits a Reeb flow with vanishing topological entropy, there exist transverse knots that force topological entropy.