bluuebunny/crossref_metadata_2025_split huggingface dataset:
Craniofacial and airway morphology of individuals with oculoauriculovertebral spectrum
Authors: Parizotto Julianna de Oliveira Lima , Peixoto Adriano Porto , Borsato Karina Tostes , Bianchi Jonas , Vendramini Pittoli Siulan , Tonello Cristiano , Gonçalves João Roberto 
Published: March 2021

AbstractObjectivesThe objectives of this study were to characterize the craniofacial and airway morphology of oculo‐auriculo‐vertebral spectrum (OAVS) individuals using computed tomography (CT) examination.Setting and Sample PopulationThis sample included individuals in the age range from 5 to 14 years, consisted of a group of 18 OAVS individuals (12 females and 6 males), Pruzansky‐Kaban1IIB and III and by a paired control group matched by age and sex for comparison of morphometric and airway variables.Materials and MethodsThrough the CT examination, airway analysis was performed using Dolphin Imaging® Software, and seven morphometric measurements were performed to evaluate craniofacial morphology by Materialize Mimics® Software. To compare airway and morphometric variables, the control group was used. Student's t test and Mann‐Whitney U test were performed to compare differences between the groups.ResultsStatistically significant differences were showed between the control and OAVS groups for the variables: total airway (TA) area, volume and MAA, RP area, RP volume, RP MAA, RG volume, RG MAA, total posterior height diff, Md incl and y‐axis asymmetry. Pearson and Spearman's correlation showed mostly moderate correlations between Mand Occlusal canting AS with TA area and RP volume, Ax‐Gn with TA area and Hy‐C3 with TA volume.ConclusionsThe OAVS's airway was altered and worse than the control group. Our results suggest that the contralateral side of OAVS individuals is unaffected; however, longitudinal assessments are needed to confirm it. Hyoid bone and postural measures play an important role in interpreting airway features of individuals with and without OAVS.
Community nurses’ experiences of the Swedish Dignity Care Intervention for older persons with palliative care needs – A qualitative feasibility study in municipal home health care
Authors: Söderman Annika , Werkander Harstäde Carina , Östlund Ulrika , Blomberg Karin 
Published: March 2021

AbstractObjectivesThe Swedish Dignity Care Intervention (DCI‐SWE) is an intervention for people with palliative care needs to enhance their dignity. The original DCI was developed in Scotland, where it was tested by nurses in municipal care. In this study, the DCI has been tested for the first time in a Swedish home health care context. The aim was to describe experiences of the DCI‐SWE from the perspectives of community nurses (CNs).MethodsThis was a feasibility study with a qualitative design. Three focus group interviews and one individual interview were performed with CNs (n = 11). Reflective diaries and field notes were written by the CNs and researchers, respectively. Data were analysed using inductive content analysis.ResultsTwo main categories and six subcategories were identified. The first main category, ‘Practising the palliative approach while responding to palliative care needs’, consisted of the subcategories: gives structure while providing palliative care; gives older people opportunities to be confirmed; and responding to existential and sensitive needs. The second main category, ‘Aspects influencing the use of the DCI‐SWE’ had two subcategories about facilitators and barriers to the use of the DCI‐SWE, and another about how to establish the DCI‐SWE in the context of home health care.ConclusionThe DCI‐SWE offers CNs an overview of older people's concerns while providing palliative care, and gives the older people opportunities to be listened to. Essential prerequisites for using the DCI‐SWE in municipal home health care are that CNs are comfortable holding conversations and are given time and space for these by the organisation. Other aspects facilitating the use of the DCI‐SWE are managers’ engagement and support, continuing training for CNs and CNs’ opportunities for reflection.
Asymptomatic Pulmonary Embolism After Shoulder Arthroscopy: Case Report and Literature Review
Authors: Ji Le , Lyu Chang‐lei , Feng Min , Qiang Hui 
Published: March 2021

Background: Pulmonary embolism (PE) is extremely rare after shoulder arthroscopy. However, early identification of the situation deserves attention due to its potential risk of causing death. By now, it is still difficult to detect the PE without symptoms and clear sources during the perioperative period.Case presentation: We report here two cases of asymptomatic PE, both happening within 24 h after shoulder arthroscopy, without any detected deep venous thrombosis of extremities. It is suspected the cases were due to the abnormal decrease in partial pressures of oxygen and arterial oxygen saturation, and were confirmed by computed tomography pulmonary angiography. We also discuss the reason why the patients showed no related symptoms when PE occurred and perform a review of PE following shoulder arthroscopy.Conclusions: This report highlights that PE could occur in the early phase after shoulder arthroscopy. An unexplained decrease in partial pressure of oxygen or arterial oxygen saturation should be considered seriously. The symptoms of PE might be masked due to patients’ tolerance to hypoxia.
Does lung function change in the months after an asthma exacerbation in children?
Authors: Martin Joanne , Pijnenburg Marielle W. , Roberts Graham , Pike Katherine C. , Petsky Helen , Chang Anne B. , Szefler Stanley J. , Gergen Peter , Vermeulen Francoise , Vael Robin , Turner Steve 
Published: March 2021

AbstractBackgroundThere are limited data describing lung function changes in children after an asthma exacerbation. Our hypothesis was that lung function does not fully recover in children in the months following an asthma exacerbation.MethodsWe used a data set of children with asthma where lung function (including FEV1, FEV1/FVC ratio and FEF25‐75) was measured at 3‐month intervals over a year. Mixed‐level models compared spirometry measured on two occasions 3 months apart before a single exacerbation (assessments 1 and 2) with measurements made on two occasions after the exacerbation (assessments 3 and 4), with adjustment for covariates. Changes in spirometry over a year were also analysed across those with exacerbations in no, one or more than one 3‐month periods.ResultsFor the 113 children who had a single exacerbation, spirometry measured at assessments 1 or 2 did not differ from measurements at assessments 3 or 4 when the whole population was considered. When stratified into tertiles by change in %FEV1 between assessments 2 and 3, those with the greater reduction were more likely to be treated with long‐acting beta‐agonist, but in this category, %FEV1 at assessment 4 had returned to the value at assessment 1. %FEV1 did not change over a 12‐month period within and between the three exacerbation categories (n = 809).ConclusionOne or more asthma exacerbation was not associated with a fall in lung function for the whole population. In a subset of individuals, lung function does fall after an exacerbation but returns to pre‐exacerbation values after a period of months.
Factors Predicting Successful Outcome for Ozone Chemonucleolysis in Lumbar Disk Herniation
Authors: Leoni Matteo Luigi Giuseppe , Caruso Annalisa , Micheli Fabrizio 
Published: March 2021

AbstractObjectivesThe aim of this study was to retrospectively investigate factors predicting a successful outcome after ozone chemonucleolysis (OCN) in patients with radicular pain and poor response to conservative treatments.MethodsUnivariable and multivariable logistic regression analysis was used to identify the predictors of good outcome after OCN. Good outcome was defined as 33% Oswestry Disability Index (ODI) reduction (model 1) or 13‐point ODI improvement (model 2) at 1 month after OCN.ResultsTwo hundred seventy‐three patients were analyzed. A significant pain reduction (pre‐operative Numerical Rating Scale [NRS] 6.7 ± 1.5, postoperative NRS 2.6 ± 2.2, P < 0.0001) and ODI improvement (pre‐operative ODI 39 ± 13.7, postoperative ODI 21.4 ± 13.8, P < 0.0001) was obtained 1 month after OCN. Pain duration (< 1 year), type of disk herniation based on Michigan State University classification (MSU), stages of disk degeneration revealed by discogram and absence of foraminal stenosis (bony or ligament flavum hypertrophy) appeared as predictors of successful outcome. Age, gender, previous spine surgery, level site of disk herniation, presence of uncontained lumbar disk herniation, and vertebral Modic changes were not statistically associated with the outcome. Both the models showed a good accuracy (model 1, area under the curve [AUC] = 0.84 ± 0.027, 95% confidence interval [CI] = 0.79 to 0.89; model 2, AUC = 0.86 ± 0.024, 95% CI = 0.81 to 0.91).ConclusionsOCN is an effective treatment for radicular pain due to disk herniation. Pain duration (< 1 year), MSU disk herniation type (1A, 1B, 1C, 2A, and 2B), disk degeneration grade 2, and absence of foraminal stenosis are all associated with the successful outcome and should be carefully evaluated before OCN.
Getting ready for the ozone battle: Vertically transmitted fungal endophytes have transgenerational positive effects in plants
Authors: Ueno Andrea C. , Gundel Pedro E. , Molina‐Montenegro Marco A. , Ramos Patricio , Ghersa Claudio M. , Martínez‐Ghersa M. Alejandra 
Published: March 2021

AbstractGround‐level ozone is a global air pollutant with high toxicity and represents a threat to plants and microorganisms. Although beneficial microorganisms can improve host performance, their role in connecting environmentally induced maternal plant phenotypes to progeny (transgenerational effects [TGE]) is unknown. We evaluated fungal endophyte‐mediated consequences of maternal plant exposure to ozone on performance of the progeny under contrasting scenarios of the same factor (high and low) at two stages: seedling and young plant. With no variation in biomass, maternal ozone‐induced oxidative damage in the progeny that was lower in endophyte‐symbiotic plants. This correlated with an endophyte‐mediated higher concentration of proline, a defence compound associated with stress control. Interestingly, ozone‐induced TGE was not associated with reductions in plant survival. On the contrary, there was an overall positive effect on seedling survival in the presence of endophytes. The positive effect of maternal ozone increasing young plant survival was irrespective of symbiosis and only expressed under high ozone condition. Our study shows that hereditary microorganisms can modulate the capacity of plants to transgenerationally adjust progeny phenotype to atmospheric change.
Utilization of 810 nm Diode Laser Treatment in Periodontitis as an Alternative to Surgical Debridement Approach
Authors: Dalvi Snehal , Khetal Namrata , Ansari Salman , Benedicenti Stefano , Hanna Reem 
Published: March 2021

AbstractThe efficacy of surgical periodontal may be compromised by inadequate patients’ self‐performed plaque control or lack of supportive periodontal therapy. This clinical case report aimed to evaluate the effectiveness of 810 nm diode laser‐assisted full‐mouth sulcular debridement, as a potential treatment modality in the management of chronic periodontitis along with a 12‐month follow‐up evaluation. Each periodontal pocket was lased within 2 mm of deepest point, using a light contact of “hot tip” of the fiber with tissue [Average power—1W, emission mode‐continuous wave, in “contact”, beam diameter—400 µm, spot area at tissue—0.0013 cm2, fluence—124.9 J cm−2, power density—796 W cm−2, total energy—300 J, total treatment duration—300 s (5 min)]. The patient was followed up to 12 months and did not report any immediate or delayed complications such as any sign of photothermal damage, pain, tissue swelling and deformation, bleeding and infection. 810 nm diode laser‐assisted sulcular debridement at low‐power settings showed overall clinical and radiographic improvements and can be deemed as a potential alternative to surgical debridement approach, in persistent moderate periodontal pockets (4–6 mm).
Adjunctive orthodontic therapy for prosthetic rehabilitation in a growing child with Axenfeld‐Rieger syndrome: A case report
Authors: Siddiqui Hamza Parvez , Sennimalai Karthik , Samrit Vilas D. , Duggal Ritu , Yadav Rahul 
Published: March 2021

AbstractAimThe congenital oligodontia impeding the development of the alveolar process resulting in disproportionate jaw growth has been previously reported. This case report describes the interdisciplinary management of an 11‐year‐old girl with Axenfeld‐Rieger syndrome exhibiting oligodontia and maxillary hypoplasia.Methods and resultsAn adjunctive orthodontic therapy was performed by taking advantage of bone‐anchored maxillary protraction (BAMP) therapy using miniplates and 24‐hour traction by intermaxillary Class III elastics. After 6 months of active treatment, the maxilla advanced by approximately 5 mm and upper lip relation improved by 3 mm without any significant changes in vertical relations. All the changes were maintained at 15th‐month follow‐up. A temporary removable prosthesis was given for immediate esthetics, and the definitive management is discussed.ConclusionThe BAMP therapy can be a befitting alternative in cases exhibiting complex presentation involving skeletal and dentoalveolar components. An appreciable profile improvement without any dentoalveolar side effects can be achieved with BAMP therapy.
Blood and bone marrow findings in two pups with mucopolysaccharidosis type VII
Authors: Corda Erica , Swenson Cheryl L. , Scott Michael A. , Sledge Dodd G. , Fyfe John C. 
Published: March 2021

AbstractRoutine blood smear findings in two of four 11‐day‐old mixed‐breed dog littermates were suggestive of a lysosomal storage disease (LSD) that was documented to be mucopolysaccharidosis type VII (MPS VII) by molecular testing. In this condition, a functional β‐glucuronidase deficiency results in the accumulation of glycosaminoglycans (GAGs) in cells and tissues where β‐glucuronidase is important in GAG degradation. Most neutrophils and a moderate number of lymphocytes within the blood had atypical cytoplasmic magenta inclusions. The bone marrow assessment from one of the two affected pups at 24 days of age revealed similar magenta granulation in myeloid precursor cells that was most prominent in promyelocytes and myelocytes. Moreover, atypical magenta material was present within vacuoles as well as extracellularly in some osteoblasts and macrophages. Histologic bone marrow sections revealed prominent vacuolation of osteoblasts, and some osteoclasts appeared separated from the bone by layers of osteoblasts or hematopoietic cells. At 2 months of age, the second affected dog showed moderate growth retardation and had similar but more prominent hematologic findings that extended to monocytes, eosinophils, and eosinophil precursors. It had an increased number of bone marrow macrophages with many vacuoles that could be seen cytologically to contain magenta material, and there was mild nonselective phagocytosis of hemic cells. Of the hematologic cells, inclusions were most prominent in promyelocytes, myelocytes, and macrophages, cells with relatively high β‐glucuronidase activity, and GAG exposure within lysosomes or lysosome‐like primary granules of granulocyte precursors.
Vitamin A failed to ameliorate clinical signs in dogs with pituitary‐dependent hypercortisolaemia
Authors: Frank Linda A. , Morandi Federica 
Published: March 2021

BackgroundIn dogs with pituitary‐dependent hypercortisolaemia, retinoic acid was shown to lower cortisol, reduce pituitary tumour size and decrease clinical signs when administered for six months. Oral vitamin A (retinol) has been used to treat various canine dermatoses in which retinoic acid has been efficacious.ObjectivesTo determine if orally administered vitamin A lowers cortisol and reduces clinical signs in dogs with pituitary‐dependent hypercortisolaemia over a five month period.Methods and materialsFive dogs were enrolled in this study. Diagnosis of hypercortisolaemia was based on the presence of at least three clinical signs and one abnormal screening test. Diagnosis of pituitary‐dependent disease was based on low dose dexamethasone suppression (LDDS) test results and symmetrical adrenal glands on ultrasound. Adrenocorticotropic hormone (ACTH) stimulation testing and adrenal ultrasound were performed at each visit. Plasma was collected at each visit and stored at –80°C for batch analysis of endogenous ACTH at conclusion of the study.ResultsFour dogs completed the study. A fifth dog died from complications of hypercortisolaemia before the third month. One dog showed improvement in clinical signs, yet there was no significant decrease in adrenal gland size or cortisol concentrations. Endogenous ACTH concentrations at the fifth month were decreased from baseline in two dogs and increased from baseline in one dog. The treatment had no adverse effects.Conclusions and clinical importanceResults from this study failed to show an improvement in clinical signs or cortisol concentration after five months of oral daily vitamin A in dogs with hypercortisolaemia.
The effects of two intramuscular sedation protocols on echocardiographic variables in cats following sedation and blood donation
Authors: Reader Rebecca C. , Yang Vicky K. , Babyak Jonathan M. , Abelson Amanda L. 
Published: March 2021

AbstractObjectiveTo compare effects of 2 IM sedation protocols, alfaxalone‐butorphanol (AB) versus dexmedetomidine‐butorphanol (DB), on echocardiographic (ECHO) variables in cats following sedation and blood donation.DesignExperimental randomized, blinded crossover study.SettingUniversity teaching hospital.AnimalsEleven client‐owned healthy cats.InterventionsCats received a baseline ECHO without sedation prior to their first donation. Cats were sedated intramuscularly with AB (alfaxalone, 2 mg/kg, and butorphanol, 0.2 mg/kg) for 1 donation and DB (dexmedetomidine, 10 μg/kg, and butorphanol 0.2, mg/kg) for another, with a minimum 6 weeks between donations. A post‐sedation, post‐donation ECHO was performed after each blood donation.Measurements and main resultsEight cats completed the study. Compared to baseline, DB combined with blood donation decreased heart rate (−84/min; P < 0.0001), fractional shortening (−16.5%; P < 0.0001), ejection fraction (‐21.0%; P = 0.0002), and cardiac output (−292 mL/min, P = 0.0001); AB combined with blood donation increased heart rate (+45/min; P = 0.0003) and decreased left ventricular end diastolic volume (−1.57 mL; P < 0.0001). Compared to AB, DB decreased heart rate (−129/min; P < 0.0001) and fractional shortening (−21.6%; P < 0.0001) and increased left ventricular end‐systolic (+1.14 mL; P = 0.0004) and diastolic volumes (+1.93 mL; P < 0.0002). Cats administered DB had a significant increase in regurgitant flow across mitral, aortic, and pulmonic valves following blood donation (P < 0.05). One cat administered DB developed spontaneous echo contrast in the left ventricle following donation.Conclusions and clinical relevanceCompared to AB, DB had more pronounced effects on ECHO variables in cats following IM sedation and blood donation. Due to its minimal impact on ECHO variables, AB may be a more desirable sedation protocol in this population of cats.
LncRNA HOTAIR modulates chondrocyte apoptosis and inflammation in osteoarthritis via regulating miR‐1277‐5p/SGTB axis
Authors: Wang Baohui , Sun Yindi , Liu Na , Liu Huajian 
Published: March 2021

AbstractOsteoarthritis (OA) is a common degenerative joint disease in the elderly. This study aimed to investigate the role and mechanism of lncRNA HOX transcript antisense RNA (HOTAIR) in lipopolysaccharide (LPS)‐treated chondrocytes in OA. CHON‐001 chondrocytes treated with LPS were used as a cell model of OA. The levels of HOTAIR, miR‐1277‐5p and small glutamine rich tetratricopeptide repeat containing beta (SGTB) were measured via quantitative real‐time polymerase chain reaction or western blot. Cell viability and apoptosis were assessed using Cell Counting Kit‐8 and flow cytometry. The levels of inflammation‐related factors were examined via enzyme‐linked immunosorbent assay (ELISA). Aggrecan and Collagen II protein levels were detected using western blot. The interaction among HOTAIR, miR‐1277‐5p and SGTB were validated by dual‐luciferase reporter analysis. HOTAIR and SGTB were up‐regulated, while miR‐1277‐5p was down‐regulated in OA cartilages and LPS‐stimulated CHON‐001 chondrocytes. HOTAIR depletion inhibited LPS‐induced apoptosis and inflammation in chondrocytes. Moreover, down‐regulation of HOTAIR attenuated LPS‐triggered chondrocyte apoptosis and inflammation via sponging miR‐1277‐5p. Also, miR‐1277‐5p repressed LPS‐induced chondrocyte apoptosis and inflammation by targeting SGTB. Furthermore, HOTAIR enhanced SGTB expression by sponging miR‐1277‐5p. HOTAIR aggravated chondrocyte apoptosis and inflammation in OA via regulating miR‐1277‐5p/SGTB pathway.
A Method for Remanufacturing Process Planning and Control Using Loosely Coupled Systems
Authors: Kimita Koji , Matschewsky Johannes , Sakao Tomohiko 
Published: March 2021

Abstract
Remanufacturing is a crucial component for our societies to move toward a circular economy. Compared with new manufacturing, the distinctive nature of remanufacturing is found to have high variability, high uncertainty and, thereby, complexity. Therefore, remanufacturers need to be able to adapt to the complexity and to flexibly adjust their processes. Especially, the ability to remanufacturing process planning and control is important. However, few practical methods supporting that are available so far. Therefore, this paper aims to propose a method for designing teams and processes in remanufacturing based on the concept of loosely coupled systems. In the proposed method, design structure matrix (DSM) is applied to identify loosely coupled sub-systems that enable to localize impacts of changes within themselves. These sub-systems are also regarded as cross-functional teams that reduce coordination efforts among line departments and, therefore, increase the adaptability against uncertainties. As a preliminary validation, the proposed method was applied to a real case of remanufacturing, and then found to be effective for creating teams and processes for remanufacturing process planning and control depending on given uncertainties.
Flank-Milling of Integral Blade Rotors Made in Ti6Al4V Using Cryo CO2 and Minimum Quantity Lubrication
Authors: González H. , Pereira O. , López de Lacalle L. N. , Calleja A. , Ayesta I. , Muñoa J. 
Published: March 2021

Abstract
This paper presents the machining of integral blade rotors (IBRs) made in Ti6Al4V using CO2 as cryogenic cooling. This kind of component is typical in gas turbines, pumps, and other rotary machines. A flank milling technique using polycrystalline diamond (PCD) tools and CO2+minimum quantity lubrication (MQL), denominated CryoMQL, is here presented as an alternative to conventional oil emulsions. The proposed approach implies a balance between technical and environmental issues. Cryogenics makes feasible the use of PCD tools avoiding problems derived from the reactivity of Ti6Al4V alloy with this type of cutting tool, which is directly related to cutting temperature. One key aspect is that CO2 has to be supplied and injected onto the cutting zone avoiding the risks of dry-ice formation, and the consequent clogging of both pipes and nozzles. For this purpose, a new device for CO2 delivery was developed, using gas and liquid CO2 simultaneously.