bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuntutan Calistung Pada Anak Usia Dini
Authors: Marlisa Lusi 
Published: August 2021

Pada program pembelajaran dalam pendidikan anak usia dini dapat berubah ubah setiap tahunnya sesuai dengan apa yang dibutuhkan oleh zaman, dimana pada dewasa ini program dari pembelajaran anak usia dini sendiri lebih mengedepankan dan menekankan pada nilai akademis terutama pada kemampuan membaca, menulis, dan berhitung dibandingkan mengembangkan sosial dan emosi anak. Ditambah dengan pandangan orang tua yang rasional, menganggap bahwa output anak yang bersekolah pada jenjang taman kanak kanak harus diajarkan dengan kemampuan membaca, menulis, dan berhitung sehingga anak memiliki kesiapan baik dalam bentuk fisik dan psikologis untuk melanjutkan pada pendidikan lebih lanjut.
Refined second boundary behavior of the unique strictly convex solution to a singular Monge-Ampère equation
Authors: Wan Haitao , Shi Yongxiu , Liu Wei 
Published: August 2021

AbstractIn this paper, we establish the second boundary behavior of the unique strictly convex solution to a singular Dirichlet problem for the Monge-Ampère equation det(D2u)=b(x)g(−u),u<0 in Ω and u=0 on ∂Ω,$$\mbox{ det}(D^{2} u)=b(x)g(-u),\,u<0 \mbox{ in }\Omega \mbox{ and } u=0 \mbox{ on }\partial\Omega, $$where Ω is a bounded, smooth and strictly convex domain in ℝN(N≥ 2),b∈ C∞(Ω) is positive and may be singular (including critical singular) or vanish on the boundary,g ∈ C1((0, ∞), (0, ∞)) is decreasing on (0, ∞) withlimt→0+g(t)=∞$ \lim\limits_{t\rightarrow0^{+}}g(t)=\infty $andgis normalized regularly varying at zero with index −γ(γ>1). Our results reveal the refined influence of the highest and the lowest values of the (N − 1)-th curvature on the second boundary behavior of the unique strictly convex solution to the problem.
Therapeutic potential of anticoagulant therapy in association with cytokine storm inhibition in severe cases of COVID-19: A case report
Authors: Xu Qiancheng , Wang Tao , Lu Weihua 
Published: August 2021

Abstract
Inflammation and coagulation are considered to the development of Coronavirus disease 2019 (COVID-19)-related hypoxemia. However, this is still controversial, which brings challenges to clinical treatment. Here, we reviewed the levels of interleukin-6 (IL-6), coagulation indexes, and clinical manifestations of a patient with severe COVID-19 after Tocilizumab administration. In this case, the patient’s body temperature quickly dropped to normal after using Tocilizumab, while C reactive protein progressively decreased and stabilized at a lower level. However, IL-6 and D-dimers increased and were accompanied by a continuous decrease of the oxygenation index. After anticoagulant therapy with heparin, D-dimer decreased slowly, gradually improving the oxygenation index and disease remission. This case suggests that the formation of microthrombus might be the main reason for COVID-19-derived hypoxemia. However, the mechanism of hypoxemia and the role of Tocilizumab in COVID-19 need further research. Nevertheless, these findings might still assist medical workers in formulating timely treatment strategies for similar severe patients.
Further insights into unusual acrania-exencephaly-anencephaly sequence caused by amniotic band – first trimester fetoscopic correlation with two- and three-dimensional ultrasound
Authors: Weichert Jan , Sepulveda Waldo , Gembicki Michael 
Published: August 2021

Abstract

Objectives
Antenatal detection of acrania-exencephaly-anencephaly (AEA) sequence beyond 10 completed weeks of gestation is usually straight-forward. An earlier detection and classification of the causative conditions prior to disaggregation of exposed dysplastic brain tissue remains challenging.

Case presentation
We present two- and three-dimensional ultrasound correlated with fetoscopic findings of an unusual type of neural tube defect at 11 gestational weeks caused by an amniotic constriction ring resulting in cystic degeneration of the developing skull.

Conclusions
By giving further illustrative insights into early defective brain development, this report confirms recent findings of an unusual subtype of acrania-exencephaly-anencephaly sequence suggesting early disruption of the developing brain, following an amniotic entrapment of the skull.
A mixed-methods assessment of the transition to a dedicated educational unit: nursing students’ perceptions and achievements
Authors: Maoz Elena , Danino Efrat , Zerahia Moran 
Published: August 2021

Abstract

Background
In 2019, our nursing school shifted clinical instruction from the traditional model to the Dedicated Educational Unit (DEU).

Objectives
To evaluate the DEU learning atmosphere, instruction quality, clinical instructor’s performance and students’ grades.

Methods
A sample of 45 nursing students completed the CLES-T; 10 of them participated in a focus group. Students’ grades in the DEU and traditional models were compared.

Results
Students (77.6%) ranked the DEU outcomes as “good”-“excellent;” “nursing care on the unit” and the “clinical faculty’s ability to integrate theory and practice” were the highest and lowest ranked categories, respectively. The focus group revealed dichotomous opinions regarding the unit atmosphere and the professional performance of the nurse manager and staff. Students in the DEU framework attained higher grades than did their counterparts.

Conclusions
Clinical instructors need specific training; the clinical staff and nurse managers should be informed about the unit atmosphere’s impact on students’ future professional decisions.
Construction of Chi(Zn/BMP2)/HA composite coating on AZ31B magnesium alloy surface to improve the corrosion resistance and biocompatibility
Authors: Zhang Qiuyang , Zhang Li , Yang Minhui , Hong Qingxiang , Yang Zhongmei , Liu Sen , Xiong Qingping , Pan Changjiang 
Published: August 2021

Abstract
As biodegradable orthopedic implant materials, magnesium alloys have been attracted enough attentions recently. However, too fast degradation in vivo, limited biocompatibilities, and insufficient antibacterial properties are three main challenges at present. In order to solve these problems, a multifunctional composite coating of Chi(Zn/BMP2)/HA was constructed on AZ31B magnesium alloy surface, successively by the alkali heating treatment, self-assembly of 16-phosphonyl-hexadecanoic acid, in situ immobilization of Chi(Zn/BMP2) (chitosan, zinc ions, and bone morphogenetic protein 2), and the deposition of HA (hydroxyapatite). The results of ATR-FTIR (attenuated total reflection Fourier transform infrared spectrum) spectra and elemental compositions confirmed that 16-phosphonyl-hexadecanoic acid, Chi(Zn/BMP2), and HA were successfully immobilized on the surface. Compared with Mg, Mg-OH, Mg-16, and Mg-Chi(Zn/BMP2), Mg-Chi(Zn/BMP2)/HA with the concave–convex structure surface significantly enhanced the hydrophilicity and corrosion resistance. On the other hand, Mg-Chi(Zn/BMP2)/HA coating also showed excellent biocompatibilities, which not only significantly promoted the osteoblast adhesion and proliferation, but also upregulated ALP and OCN expression of osteoblasts. Furthermore, due to the synergistic antibacterial effect of zinc ions and chitosan, Mg-Chi(Zn/BMP2)/HA showed a good antibacterial property against Escherichia coli (E. coli). Therefore, it can be said that the method used in this work has a good application prospect in improving the corrosion resistance, biocompatibility of magnesium alloys, and inhibiting infections against E. coli.
Salvage surgery for cervical radioiodine refractory 18F-FDG-PET positive recurrence of papillary thyroid cancer
Authors: Chiapponi C , Alakus H , Faust M , Schultheis A M , Rosenbrock J , Schmidt M 
Published: August 2021

Purpose
Five percent of patients with differentiated thyroid cancer are diagnosed with radioiodine refractory relapse in the course of the disease. For isolated or oligometastatic cervical recurrence, resection or another local treatment is recommended. In this study, the impact of surgical treatment of cervical radioiodine refractory 18F-FDG-PET positive relapse of papillary thyroid cancer (PTC) was evaluated.

Methods
Patients receiving radioiodine therapy between 2005 and 2015 at the University Hospital of Cologne, Germany, for PTC were screened. The subgroup of patients undergoing surgery during the course of disease after recommendation by a multidisciplinary endocrine team for cervical radioiodine refractory 18F-FDG-PET positive recurrence was identified. Demographics, clinic-pathologic characteristics, oncologic treatment, and outcome were analyzed.

Results
Thirty (3%) of 969 patients with PTC treated with radioiodine therapy at our institution underwent surgery for radioiodine refractory 18F-FDG-PET positive cervical recurrence during the course of the disease. In eight (26.6%) patients, more than one operation was performed. Sixteen (53%) patients received external beam radiation therapy (EBRT) after surgery. Follow-up was on average, 79.2 ± 61.6 months after the last surgical treatment. Biochemical and radiological cure was seen in 12 (40%) patients. Remission was significantly more frequent in younger patients (P = 0.0001) with lymph node rather than soft tissue tumor recurrence (P = 0.004).

Conclusions
Surgical treatment of radioiodine refractory 18F-FDG-PET positive cervical recurrence led to biochemical and radiological cure in about 40% of patients in this study. Further data are needed concerning risk stratification of potential subgroups benefitting of surgical approach and the possible role of EBRT after repetitive surgery.
Optimal drying conditions for valorization of industrial apple pomace: Potential source of food bioactive compounds
Authors: Gonelimali Faraja Deo , Szabó-Nótin Beatrix , Máté Mónika 
Published: August 2021

AbstractApple pomace contains a large amount of useful bioactive compounds that have wide application in the food industry. In this study the effect of drying temperature and pressure (high temperature 80 °C and low temperature 60 °C using a conventional oven and a combination of conventional plus vacuum drying oven) on the antioxidant capacity and phenolic compounds of apple pomace extract was investigated. For a combination of conventional and vacuum drying ovens, samples were first dried by a conventional oven to a moisture content of approximately 10% then vacuum dried to reach a final moisture content of 3–4%. After the drying processes, ethanolic extraction was performed and the amount of total polyphenol and the antioxidant capacity (FRAP) were evaluated to determine a best drying method. The drying curves were also determined. The drying temperature affects the duration of the drying, the rate of water loss, and the remaining amount of antioxidant compounds.
Pengaruh Kombinasi Tepung Sagu dan Tepung Udang Rebon terhadap Karakteristik Kimia dan Organoleptik Makaroni
Authors: Suparmi Suparmi , Sumarto Sumarto , Sari Nur Ira , Hidayat Taufik 
Published: August 2021

Penelitian ini bertujuan untuk menentukan karakteristik dari makaroni tepung sagu yang difortifikasi dengan tepung udang rebon. Metode yang digunakan adalah metode eksperimen dengan menggunakan Rancangan Acak Lengkap, dengan perlakuan tiga kombinasi antara tepung sagu dan tepung udang rebon yaitu MS0 (kontrol tanpa tepung udang rebon), MS1 (kombinasi 2:1) dan MS2 (kombinasi 1:1) diulang sebanyak 3 kali. Parameter yamg diuji yaitu mutu proksimat (kadar air, kadar abu, kadar protein, kadar lemak, dan kadar karbohidrat), daya serap air dan mutu organoleptik (rupa, tekstur, aroma, rasa). Hasil penelitian menunjukkan bahwa pada pembuatan makaroni tepung sagu dengan penambahan tepung udang rebon berpengaruh nyata terhadap nilai proksimat, daya serap air dan nilai organoleptik. Perlakuan terbaik adalah MS1 (kombinasi 2:1) memiliki karakteristik rupa dengan warna kuning cerah, aroma tidak amis udang, tekstur padat tidak keras, dan rasa gurih. Nilai kadar protein (19,67%) air (6,98%), lemak (4,13%), abu (2,57%), dan karbohidrat (by different) 65,65%. Serta secara keseluruhan parameter makaroni tepung sagu dengan perlakuan penambahan 50% tepung udang rebon memenuhi standar (SNI 01-3777-1995 No.45)
Clinical efficacy of the drug 200 mg silver proteinate in the complex therapy of acute infectious rhinitis in children, which occurred as part of an acute respiratory infection
Authors:   Novosibirsk State Medical University, Novosibirsk, 630091, Russia, Kiselev A. B. , Abdulkerimov Kh. T. ,   Ural State Medical University, Yekaterinburg, 620028, Russia, Terskova N. E. ,   Voino-Yasenetskii Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia, Chaukina V. A. ,   Novosibirsk State Medical University, Novosibirsk, 630091, Russia
Published: August 2021

The effectiveness of pharmacotherapy of acute infectious rhinitis in children by means of drugs from the list of medicines of the J00 Standard and in addition to this pharmacotherapy with the drug silver proteinate – 200 mg nasal spray Sialor® (manufacturer of JSC «Production Pharmaceutical Company “Obnovlenie”, Russia) was evaluated in a multicenter randomized comparative study. A higher quality of treatment was demonstrated when using 200 mg silver proteinate (Sialor®) in the form of a nasal spray in complex therapy. The article presents evidence of the feasibility of including the drug 200 mg silver proteinate in the list of medicines of the J00 Standard.
A concepção teórico-política do projeto Future-se e a concepção de internacionalização da educação
Authors: Martins Tânia , Vitti Sylvia Cristina de Azevedo 
Published: August 2021

O objetivo do artigo é apresentar o Programa Institutos e Universidades Empreendedoras e Inovadoras (Future-se) e a sua concepção de internacionalização da educação. O plano de trabalho incluiu analisar os eixos do projeto de lei, considerando os artigos da área do ensino superior e das entidades educacionais. Conclui-se que o Future-se tem uma visão míope e estreita de internacionalização da educação, como estratégia para promover uma privatização indireta das instituições de ensino superior, legitimando-se pelo discurso da integração ao mercado internacional.
Ensino história indígena em livros didáticos: problematizações a partir de uma coletânea distribuída na rede municipal de ensino de Florianópolis, SC
Authors: Bringmann Sandor 
Published: August 2021

O presente artigo tem como intuito contribuir com algumas reflexões acerca do ensino de História Indígena na Educação Básica a partir da análise e problematização dos conteúdos presentes na coletânea didática Vontade de Saber: História, distribuída a escolas da rede municipal de educação de Florianópolis-SC. A análise fundamenta-se em dispositivos legais, como a Lei n. 11645/08, as Diretrizes Operacionais para a Implementação da História e das Culturas dos Povos Indígenas na Educação Básica (2016) e nas normativas do Programa Nacional do Livro e do Material Didático (PNLD). A problematização dos conteúdos e as indicações propositivas foram orientadas pelos princípios teórico-metodológicos da chamada Nova História Indígena, cujos preceitos vêm influenciando a produção historiográfica na área ao longo dos últimos 25 anos, promovendo olhares e práticas que ressaltam e valorizam o protagonismo indígena e sua agência histórica.
Resistências epistemológicas: entrevista com Dominique Tilkin Gallois
Authors: Maíra Klein Tatiane , Marques Pereira Levi 
Published: August 2021

Tivemos o privilégio de trabalhar em alguns momentos de nossas vidas com Dominique Tilkin Gallois, professora colaboradora sênior da Universidade de São Paulo (USP) e pesquisadora do Centro de Estudos Ameríndios (CEstA). Nessas experiências de orientação à pesquisa e trabalho, ela nos beneficiou com sua generosidade e profundo conhecimento acerca dos modos indígenas de conhecer e metodologias de formação de pesquisadores indígenas, o que nos inspirou a realizar essa entrevista. Feita de maneira remota na manhã do dia 23 de junho de 2020[1], a entrevista nos traz um pouco de sua história e de como se tornou pesquisadora em Etnologia e História indígena, abordando temas de grande relevância para as pesquisas realizadas com indígenas e por indígenas – e contribuições importantes no campo teórico-metodológico e bem como nos processos políticos inevitavelmente envolvidos na pesquisa.
Como sua destacada atuação como antropóloga não se restringe aos temas acima, a conversa acabou sendo tangenciada por outros assuntos centrais em sua trajetória, como tradições orais e cosmologias ameríndias, políticas indígenas, patrimônio cultural e conhecimentos tradicionais. O modo sempre inovador como Dominique articula investimento acadêmico e ação indigenista também ganha destaque através dos relatos de sua experiência na assessoria direta a comunidades indígenas no Amapá, norte do Pará e outros estados. Essas reflexões compartilhadas nos permitiram uma aproximação com um certo fazer antropológico, que convidamos os leitores da revista a conhecer. Eis a “antropologia comprometida” de Dominique Tilkin Gallois.
Thoracic Morphology and Bronchial Narrowing Are Related to Pulmonary Function in Adolescent Idiopathic Scoliosis
Authors: Farrell James , Garrido Enrique , Vavruch Ludvig , Schlösser Tom P.C. 
Published: August 2021

Background:In adolescent idiopathic scoliosis (AIS), lung function impairment is not necessarily related to the coronal spinal deformity. Recently, right-sided bronchial narrowing has been reported in thoracic AIS. The aim of this study was to describe the relation of chest and spinal deformity parameters, bronchial narrowing, and lung volumes with pulmonary function in preoperative AIS.Methods:Spinal radiographs, low-dose computed tomographic (CT) scans of the spine including the chest, and pulmonary function tests were retrospectively collected for 85 preoperative patients with thoracic AIS in 2 centers and were compared with 14 matched controls. Three-dimensional lung and airway reconstructions were acquired. Correlation analysis was performed in which radiographic spinal parameters, CT-based thoracic deformity parameters (rib-hump index [RHi], spinal penetration index, endothoracic hump ratio, hemithoracic-width ratio), lung volume asymmetry, and bronchial cross-sectional area were compared with percent-of-predicted spirometry results.Results:Forty-one patients (48%) had a percent-of-predicted forced expiratory volume in 1 second (FEV1%) or percent-of-predicted forced vital capacity (FVC%) of <65%, and 17 patients (20%) had obstructive lung disease. All thoracic deformity parameters correlated significantly with FEV1% and FVC%; RHi was found to be the best correlate (rs= −0.52 for FEV1% and −0.54 for FVC%). Patients with AIS with impaired pulmonary function had hypokyphosis, a larger rib hump, increased spinal and thoracic rotation, a narrower right hemithorax, and increased intrusion of the spine into the chest. Spinal intrusion correlated with right-sided bronchial narrowing, relative right lung volume loss, and decreased FEV1% and FVC%. Multivariate regression including spinal and thoracic deformity parameters, lung volume asymmetry, and airway parameters could explain 57% of the variance in FEV1% and 54% of the variance in FVC%.Conclusions:Chest intrusion by the endothoracic hump is related to right-sided bronchial narrowing and lung function loss in preoperative AIS. The findings support the theory that ventilatory dysfunction in thoracic AIS is not only restrictive but frequently has an obstructive component, especially in patients with hypokyphosis. RHi is the most predictive chest parameter for lung function loss.Level of Evidence:PrognosticLevel III. See Instructions for Authors for a complete description of levels of evidence.
Three-Year Rates of Reoperation and Revision Following Mobile Versus Fixed-Bearing Total Ankle Arthroplasty
Authors: Assal M. , Kutaish H. , Acker A. , Hattendorf J. , Lübbeke A. , Crevoisier X. 
Published: August 2021

Background:
Currently, the implants utilized in total ankle arthroplasty (TAA) are divided between mobile-bearing 3-component and fixed-bearing 2-component designs. The literature evaluating the influence of this mobility difference on implant survival is sparse. The purpose of the present study was therefore to compare the short-term survival of 2 implants of similar design from the same manufacturer, surgically implanted by the same surgeons, in fixed-bearing or mobile-bearing versions.

Methods:
All patients were enrolled who underwent TAA with either the mobile-bearing Salto (Tornier and Integra) or the fixed-bearing Salto Talaris (Integra) in 3 centers by 2 surgeons between January 2004 and March 2018. All patients who underwent TAA from January 2004 to April 2013 received the Salto implant, and all patients who underwent TAA after November 2012 received the Salto Talaris implant. The primary outcome was time, within 3 years, to first all-cause reoperation, revision of any metal component, and revision of any component, including the polyethylene insert. Secondary outcomes included the frequency, cause, and type of reoperation.

Results:
A total of 302 consecutive patients were included, of whom 171 received the mobile-bearing and 131 received the fixed-bearing implant. The adjusted hazard ratio for all-cause reoperation was 1.42 (95% confidence interval [CI], 0.67 to 3.00; p = 0.36); for component revision, 3.31 (95% CI, 0.93 to 11.79; p = 0.06); and for metal component revision, 2.78 (95% CI, 0.58 to 13.33; p = 0.20). A total of 31 reoperations were performed in the mobile-bearing group compared with 14 in the fixed-bearing group (p = 0.07). More extensive reoperation procedures were performed in the mobile-bearing group.

Conclusions:
With the largest comparison of 2 implants of similar design from the same manufacturer, the present study supports the use of a fixed-bearing design in terms of short-term failure. We found a 3-times higher rate of revision among mobile-bearing implants compared with fixed-bearing implants at 3 years after TAA. Reoperations, including first and subsequent procedures, tended to be less common and the causes and types of reoperations less extensive among fixed-bearing implants.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.