bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metastatic pheochromocytoma and paraganglioma: signs and symptoms related to catecholamine secretion
Authors: Li Minghao , Pamporaki Christina , Fliedner Stephanie M. J. , Timmers Henri J. L. M. , Nölting Svenja , Beuschlein Felix , Prejbisz Aleksander , Remde Hanna , Robledo Mercedes , Bornstein Stefan R. , Lenders Jacques W. M. , Eisenhofer Graeme , Bechmann Nicole 
Published: March 2021

Abstract
Background
The presence or future development of metastatic pheochromocytomas or paragangliomas (mPPGLs) can be difficult to diagnose or predict at initial presentation. Since production of catecholamines from mPPGLs is different from non-metastatic tumors (non-mPPGLs), this study aimed to clarify whether presenting catecholamine-related signs and symptoms (cSS) might also differ.

Methods
The study included 249 patients, 43 with mPPGL and 206 with non-mPPGL. Clinical data at the time of biochemical diagnosis (i.e. at entry into the study) were used to generate a cumulative score of cSS for each patient.

Results
Patients with mPPGL were significantly younger (43.3 ± 14 vs. 48.9 ± 16.1 years) and included a lower proportion of females (39.5% vs. 60.7%) than patients with non-mPPGLs. Frequencies of signs and symptoms did not differ between the two groups. Patients with mPPGLs had lower (P < 0.001) urinary excretion of epinephrine (3.5 (IQR, 1.9—6.5) µg/day) than those with non-mPPGLs (19.1 (IQR, 4.3—70.2) µg/day). There was no difference in urinary excretion of norepinephrine. In patients with mPPGLs a high cSS score was associated with high urinary excretion of norepinephrine and normetanephrine. In contrast, in patients with non-mPPGLs, a high cSS was associated with high urinary excretion of epinephrine and metanephrine.

Conclusion
Although presenting signs and symptoms were associated with production of norepinephrine in patients with mPPGLs and of epinephrine in patients with non-mPPGLs, there were no differences in signs and symptoms between the two groups. Therefore, consideration of signs and symptoms does not appear helpful for distinguishing patients with and without mPPGLs.
Socioeconomic benefits of conserving Iran’s water resources through modifying agricultural practices and water management strategies
Authors: Karandish Fatemeh 
Published: March 2021

AbstractSustainable development requires modifying the current consumption pattern of natural resources. This study investigates efficient tactics for reducing the unsustainability and inefficiency of human’s food-related blue water consumption alongside improving national environmental and socioeconomic status. As a case study for Iran, 15 alternative management scenarios (AMS) were defined compared to the current on-farm management, and their effects were assessed on a monthly scale. Based on the results, 45.5 billion m3 y−1 (BCM) blue water is consumed within the croplands, 78% and 34% of which are unsustainable and inefficient, respectively. AMCs reduces the unsustainable and inefficient blue water consumption by 2–17 BCM and 2–13 BCM, respectively. The combination of yield gap closure, drip irrigation, soil mulching, and deficit irrigation has the largest effect on blue water saving; it releases or changes the status of monthly blue water scarcity in 11 provinces; increases field-employees by 132%, food security by 9%, international food-export by 87%, and gross domestic production by 54%. However, it doesn’t fully address blue water overconsumption in the summer period; hence, further measures are needed to reduce blue water scarcity to the sustainable level in these environmental hotspots.
On fractional Orlicz–Sobolev spaces
Authors: Alberico Angela , Cianchi Andrea , Pick Luboš , Slavíková Lenka 
Published: March 2021

AbstractSome recent results on the theory of fractional Orlicz–Sobolev spaces are surveyed. They concern Sobolev type embeddings for these spaces with an optimal Orlicz target, related Hardy type inequalities, and criteria for compact embeddings. The limits of these spaces when the smoothness parameter$$s\in (0,1)$$s∈(0,1)tends to either of the endpoints of its range are also discussed. This note is based on recent papers of ours, where additional material and proofs can be found.
Brain networks in eating disorders: a systematic review of graph theory studies
Authors: Collantoni Enrico , Alberti Francesco , Meregalli Valentina , Meneguzzo Paolo , Tenconi Elena , Favaro Angela 
Published: March 2021

Abstract
Purpose
Recent evidence from neuroimaging research has shown that eating disorders (EDs) are characterized by alterations in interconnected neural systems, whose characteristics can be usefully described by connectomics tools. The present paper aimed to review the neuroimaging literature in EDs employing connectomic tools, and, specifically, graph theory analysis.

Methods
A systematic review of the literature was conducted to identify studies employing graph theory analysis on patients with eating disorders published before the 22nd of June 2020.

Results
Twelve studies were included in the systematic review. Ten of them address anorexia nervosa (AN) (AN = 199; acute AN = 85, weight recovered AN with acute diagnosis = 24; fully recovered AN = 90). The remaining two articles address patients with bulimia nervosa (BN) (BN = 48). Global and regional unbalance in segregation and integration properties were described in both disorders.

Discussion
The literature concerning the use of connectomics tools in EDs evidenced the presence of alterations in the topological characteristics of brain networks at a global and at a regional level. Changes in local characteristics involve areas that have been demonstrated to be crucial in the neurobiology and pathophysiology of EDs. Regional imbalances in network properties seem to reflect on global patterns.

Level of evidence
Level I, systematic review.
Towards Designing Profitable Courses: Predicting Student Purchasing Behaviour in MOOCs
Authors: Alshehri Mohammad , Alamri Ahmed , Cristea Alexandra I. , Stewart Craig D. 
Published: March 2021

AbstractSince their ‘official’ emergence in 2012 (Gardner and Brooks 2018), massive open online courses (MOOCs) have been growing rapidly. They offer low-cost education for both students and content providers; however, currently there is a very low level of course purchasing (less than 1% of the total number of enrolled students on a given online course opt to purchase its certificate). The most recent literature on MOOCs focuses on identifying factors that contribute to student success, completion level and engagement. One of the MOOC platforms’ ultimate targets is to become self-sustaining, enabling partners to create revenues and offset operating costs. Nevertheless, analysing learners’ purchasing behaviour on MOOCs remains limited. Thus, this study aims to predict students purchasing behaviour and therefore a MOOCs revenue, based on the rich array of activity clickstream and demographic data from learners. Specifically, we compare how several machine learning algorithms, namely RandomForest, GradientBoosting, AdaBoost and XGBoost can predict course purchasability using a large-scale data collection of 23 runs spread over 5 courses delivered by The University of Warwick between 2013 and 2017 via FutureLearn. We further identify the common representative predictive attributes that influence a learner’s certificate purchasing decisions. Our proposed model achieved promising accuracies, between 0.82 and 0.91, using only the time spent on each step. We further reached higher accuracy of 0.83 to 0.95, adding learner demographics (e.g. gender, age group, level of education, and country) which showed a considerable impact on the model’s performance. The outcomes of this study are expected to help design future courses and predict the profitability of future runs; it may also help determine what personalisation features could be provided to increase MOOC revenue.
Covid-19 and the need for more history and philosophy of RNA
Authors: Guttinger Stephan 
Published: March 2021

AbstractRNA is central to the COVID-19 pandemic—it shapes how the SARS Coronavirus 2 (SARS-CoV-2) behaves, and how researchers investigate and fight it. However, RNA has received relatively little attention in the history and philosophy of the life sciences. By analysing RNA biology in more detail, philosophers and historians of science could gain new and powerful tools to assess the current pandemic, and the biological sciences more generally.
Primer biases in the molecular assessment of diet in multiple insectivorous mammals
Authors: Browett Samuel S. , Curran Thomas G. , O’Meara Denise B. , Harrington Andrew P. , Sales Naiara Guimarães , Antwis Rachael E. , O’Neill David , McDevitt Allan D. 
Published: March 2021

AbstractOur understanding of trophic interactions of small insectivorous mammals has been drastically improved with the advent of DNA metabarcoding. The technique has continued to be optimised over the years, with primer choice repeatedly being a vital factor for dietary inferences. However, the majority of dietary studies examining the effect of primer choice often rely on in silico analyses or comparing between species that occupy an identical niche type. Here, we apply DNA metabarcoding to empirically compare the prey detection capabilities of two widely used primer sets when assessing the diets of a flying (lesser horseshoe bat; Rhinolophus hipposideros) and two ground-dwelling insectivores (greater white-toothed shrew; Crocidura russula and pygmy shrew; Sorex minutus). Although R. hipposideros primarily rely on two prey orders (Lepidoptera and Diptera), the unique taxa detected by each primer shows that a combination of primers may be the best approach to fully describe bat trophic ecology. However, random forest classifier analysis suggests that one highly degenerate primer set detected the majority of both shrews’ diet despite higher levels of host amplification. The wide range of prey consumed by ground-dwelling insectivores can therefore be accurately documented from using a single broad-range primer set, which can decrease cost and labour. The results presented here show that dietary inferences will differ depending on the primer or primer combination used for insectivores occupying different niches (i.e., hunting in the air or ground) and demonstrate the importance of performing empirical pilot studies for novel study systems.
Community-in-the-loop: towards pluralistic value creation in AI, or—why AI needs business ethics
Authors: Häußermann Johann Jakob , Lütge Christoph 
Published: March 2021

AbstractToday, due to growing computing power and the increasing availability of high-quality datasets, artificial intelligence (AI) technologies are entering many areas of our everyday life. Thereby, however, significant ethical concerns arise, including issues of fairness, privacy and human autonomy. By aggregating current concerns and criticisms, we identify five crucial shortcomings of the current debate on the ethics of AI. On the threshold of a third wave of AI ethics, we find that the field eventually fails to take sufficient account of the business context and deep societal value conflicts the use of AI systems may evoke. For even a perfectly fair AI system, regardless of its feasibility, may be ethically problematic, a too narrow focus on the ethical implications of technical systems alone seems insufficient. Therefore, we introduce a business ethics perspective based on the normative theory of contractualism and conceptualise ethical implications as conflicts between values of diverse stakeholders. We argue that such value conflicts can be resolved by an account of deliberative order ethics holding that stakeholders of an economic community deliberate the costs and benefits and agree on rules for acceptable trade-offs when AI systems are employed. This allows AI ethics to consider business practices, to recognise the role of firms, and ethical AI not being at risk to provide a competitive disadvantage or in conflict with the current functioning of economic markets. By introducing deliberative order ethics, we thus seek to do justice to the fundamental normative and political dimensions at the core of AI ethics.
Open vs Endovascular Treatment of Traumatic Peripheral Arterial Injury: Propensity Matched Analysis
Authors: Asmar Samer , Bible Letitia , Obaid Omar , Tang Andrew , Khurrum Muhammad , Castanon Lourdes , Ditillo Michael , Joseph Bellal 
Published: March 2021

BACKGROUND:
Arterial injuries occur in the setting of blunt and penetrating trauma. Despite increasing use, there remains a paucity of data comparing long-term outcomes of endovascular vs open repair management of these injuries. The aim of our study was to compare outcomes and readmission rates of open vs endovascular repair of traumatic arterial injuries.

STUDY DESIGN:
The National Readmission Database (2011–2014) was queried for all adult (age ≥ 18 y) patients presenting with peripheral arterial (axillary, brachial, femoral, and popliteal) injuries. Patients were stratified into 2 groups based on intervention: open vs endovascular approach. Propensity score matching (1:2 ratio) was performed. Outcomes measures were complications, length of stay (LOS), 30-day readmission, and cost of readmission.

RESULTS:
A matched cohort of 786 patients was obtained (endovascular: 262, open: 524). Mean age was 45 ± 17 years, and 79% were males. Median LOS was 4 (range 2–6) days for the endovascular group vs 3 (range 2–5) days for the open group (p < 0.01). The endovascular group had higher rates of seroma (4% vs 2%; p = 0.04) and arterial thrombosis (13% vs 7%; p < 0.01) during index hospitalization. Patients who underwent endovascular repair had higher 30-day readmission (11% vs 7%; p = 0.03) and a higher 30-day open-reoperation rate (6% vs 2%; p < 0.01). On subanalysis of the patients who were readmitted, the median cost of each readmission was higher in the endovascular group $47,000 ($27,202–$56,763) compared with $21,000 ($11,889–$43,503) in the open group.

CONCLUSIONS:
Endovascular repair for peripheral arterial injuries was associated with higher rates of in-hospital complications, readmissions, and costs. As this new technology continues to undergo refinement, a thorough re-evaluation of its indications, risks, and benefits is warranted.
Diode-pumped, electro-opticallyQ-switched, cryogenic Tm:YAG laser operating at 1.88 μm
Authors: Körner Jörg , Jambunathan Venkatesan , Yue Fangxin , Reiter Jürgen , Slezák Ondřej , Navrátil Petr , David Samuel Paul , Lucianetti Antonio , Hein Joachim , Mocek Tomáš , Kaluza Malte C. 
Published: March 2021

AbstractWe present a diode-pumped, electro-opticallyQ-switched Tm:YAG laser with a cryogenically cooled laser crystal at 120 K. Output pulses of up to 2.55 mJ and 650 ns duration were demonstrated in an activelyQ-switched configuration with a repetition rate of 1 Hz. By using cavity dumping the pulse duration was shortened to 18 ns with only a slightly lower output energy of 2.22 mJ. Furthermore, using a simplified rate equation model, we discuss design constraints on the pump fluence in a pulse pump approach for Tm:YAG to maximize the energy storage capability at a given pump power.
Antarctic pack ice seal observations during spring across the Lazarev Sea
Authors: Bester Marthán N. , Lübcker Nico , Haddad Wiam , Bornemann Horst , Wege Mia 
Published: March 2021

Abstract
The distribution, density and percentage contribution of pack ice seals during ship-board censuses in the marginal sea ice zone beyond the Lazarev Sea in spring 2019 are presented. Adult/juvenile crabeater seals (n = 19), leopard seals (n = 3) and Ross seals (n = 10) were sighted during 582.2 nm of censuses along the ship’s track line in the area bounded by 00°00’–22°E and 56°–60°S. Antarctic fur seals (n = 21) were only encountered on the outer fringes of the pack ice, and Weddell seals were absent due to their primary use of fast ice and inner pack ice habitats close to the coast. Crabeater seal sightings included juveniles (n = 2) and another four groups of 2–3 unclassified crabeater seals, singletons (n = 5), single mothers with pups (n = 3) and a family group (n = 1 triad). Only one leopard seal attended a pup, while no Ross seal pups were located. The survey was likely of insufficient effort, in both extent (north of 60°S) and duration (18 days), to locate seals in considerable numbers this early (late October/early November) in their austral spring breeding season.
Recovering authentic global position system L1 signals under spoofing using dual receiver direct positioning
Authors: Sun Chao , Cheong Joon Wayn , Dempster Andrew G. , Zhao Hongbo , Feng Wenquan 
Published: March 2021

AbstractSpoofing is a kind of deliberate interference that aims to manipulate global navigation satellite system (GNSS) receivers into counterfeit position solutions. Conventional anti-spoofing methods are implemented prior to the calculation of the position solution, depending on the specific spoofing attack mechanisms. The paper presents a spoofing detection and mitigation method implemented in the position domain. The proposed method projects the correlograms of the visible satellites to a position-clock bias domain to construct the position domain projected correlogram. P(Y) code signatures retrieved from a reference station receiver are used to identify the counterfeit position solution and remove it from the victim receiver. Compared with the conventional single-channel spoofing detection technique, the proposed anti-spoofing method is more robust against thermal noise by combining the energy from multiple satellites. Detailed mathematical derivation of the statistical characteristics of this method is presented. Its effectiveness is validated using a realistic dataset generated by a Spirent GNSS simulator and NordNav wideband front-end. Results show that the proposed algorithm is capable of not only detecting a spoofing attack but also removing the spoofing effect from the victim receiver.
Laptop-Administered NIH Toolbox and Cogstate Brief Battery in Community-Dwelling Black Adults: Unexpected Pattern of Cognitive Performance between MCI and Healthy Controls
Authors: Kairys Anson , Daugherty Ana , Kavcic Voyko , Shair Sarah , Persad Carol , Heidebrink Judith , Bhaumik Arijit , Giordani Bruno 
Published: March 2021

AbstractObjective:Black adults are approximately twice as likely to develop Alzheimer’s disease (AD) than non-Hispanic Whites and access diagnostic services later in their illness. This dictates the need to develop assessments that are cost-effective, easily administered, and sensitive to preclinical stages of AD, such as mild cognitive impairment (MCI). Two computerized cognitive batteries, NIH Toolbox-Cognition and Cogstate Brief Battery, have been developed. However, utility of these measures for clinical characterization remains only partially determined. We sought to determine the convergent validity of these computerized measures in relation to consensus diagnosis in a sample of MCI and healthy controls (HC).Method:Participants were community-dwelling Black adults who completed the neuropsychological battery and other Uniform Data Set (UDS) forms from the AD centers program for consensus diagnosis (HC = 61; MCI = 43) and the NIH Toolbox-Cognition and Cogstate batteries. Discriminant function analysis was used to determine which cognitive tests best differentiated the groups.Results:NIH Toolbox crystallized measures, Oral Reading and Picture Vocabulary, were the most sensitive in identifying MCI apart from HC. Secondarily, deficits in memory and executive subtests were also predictive. UDS neuropsychological test analyses showed the expected pattern of memory and executive functioning tests differentiating MCI from HC.Conclusions:Contrary to expectation, NIH Toolbox crystallized abilities appeared preferentially sensitive to diagnostic group differences. This study highlights the importance of further research into the validity and clinical utility of computerized neuropsychological tests within ethnic minority populations.
Deep fluids and their role in hydrocarbon migration and oil deposit formation exemplified by supercritical СO2
Authors: LIFSHITS Sara 
Published: March 2021

ABSTRACTHydrocarbon migration mechanism into a reservoir is one of the most controversial in oil and gas geology. The research aimed to study the effect of supercritical carbon dioxide (СО2) on the permeability of sedimentary rocks (carbonates, argillite, oil shale), which was assessed by the yield of chloroform extracts and gas permeability (carbonate, argillite) before and after the treatment of rocks with supercritical СО2. An increase in the permeability of dense potentially oil-source rocks has been noted, which is explained by the dissolution of carbonates to bicarbonates due to the high chemical activity of supercritical СО2 and water dissolved in it. Similarly, in geological processes, the introduction of deep supercritical fluid into sedimentary rocks can increase the permeability and, possibly, the porosity of rocks, which will facilitate the primary migration of hydrocarbons and improve the reservoir properties of the rocks. The considered mechanism of hydrocarbon migration in the flow of deep supercritical fluid makes it possible to revise the time and duration of the formation of gas–oil deposits decreasingly, as well as to explain features in the formation of various sources of hydrocarbons and observed inflow of oil into operating and exhausted wells.
Maternal and Perinatal Factors Associated With Twin Pregnancies in Ecuador
Authors: Orozco-Quinga Ximena , González-Andrade Fabricio 
Published: March 2021

AbstractThere are few studies on twins in Ecuador and Latin America. It requires a better understanding of perinatal conditions, especially from an ethnic perspective. This work aims to assess perinatal factors related to twin pregnancy in Ecuadorian Mestizo individuals. We performed an epidemiological, observational and cross-sectional study at the Hospital San Francisco and Hospital Nueva Aurora in Quito, Ecuador, from November 2019 to January 2020. It included 203 newborns from twin pregnancies, including mothers with and without pathological history. The average gestational age was 31 weeks, and the APGAR score at first minute was 6.86, with significant differences. Regarding the metabolic balance, the mean pH was 6.14; and bicarbonate was 11.57, with significant differences. Twins had intrauterine growth restriction in 6.9% of cases, with significant differences (p = .003); 81.4% required supplemental oxygen, with significant differences (p = .002); 93% required noninvasive mechanical ventilation (NIMV), with significant differences (p = . 003); 93% required inotropic and sedation, with substantial differences; 69% required antibiotics (≥21 days), with significant differences (p = .014); and 17.2% needed between 8 to 14 days of hospitalization, and 51% more than 28 days, with significant differences. The studied mothers’ demographic profile was mostly Mestizos, with an average age of 32 years, and 93% had a poverty status. Most of the twins were diamniotic monochorial and were discordant twins. It found jaundice, premature anemia and sepsis in 100% of twins and hyaline membrane disease in 89.66% of twins. Twins of women with relevant prenatal care had more premature births (30.4 ± 2.6 weeks), more acid−base imbalance, APGAR at ≥7 min in 90% of cases, and patent ductus arteriosus in all. There was also a greater need for double intensive phototherapy than twins of healthy women.