bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRICOEPITELIOMA MÚLTIPLO EM CRIANÇA - RELATO DE CASO
Authors: Silva Thiago Henrique , Vidal de Oliveira Victor , Leonardo Sangalli Thiago , Fernandes de Sousa Thácila , Ribeiro Guedes Virgilio , Fernandes da Costa Nilo 
Published: December 2021

Resumo: Introdução: Os tricoepiteliomas são tumores benignos raros originados do folículo piloso, apresentam-se como lesões únicas ou múltiplas. Os casos já relatados iniciam na infância e aumentam em número e tamanho durante a vida adulta. O objetivo do artigo é apresentar essa patologia de baixa incidência e diagnóstico desafiador. Desenvolvimento: É apresentado o caso de paciente de 9 anos do sexo feminino, acompanhada desde os 5 anos, com queixa de múltiplas pápulas da cor da pele, bem delimitadas, circulares, dispostas difusamente em região facial, com surgimento a partir dos 3 anos. As análises dermatoscópica e anatomopatológica foram coerentes com o diagnóstico de tricoepitelioma múltiplo. Considerações Finais: É preciso fazer diagnósticos diferenciais subsequentes com tumores malignos, pois existe na literatura relato de transformação maligna para carcinoma basocelular em lesões mais antigas. O tratamento habitual é a exérese da lesão, mas deve ser individualizado, avaliando as chances de recidiva, o potencial de lesão cicatricial e impacto estético.
MANEJO DO TRABALHO DE PARTO PREMATURO
Authors: Soares Nayara Pettine Dias , Ruiz de Moraes Fábio Roberto , Martins Aires Marcelo Augusto , Borges Corrêa Bichuete Isabela 
Published: December 2021

INTRODUÇÃO: A prematuridade é definida como o nascimento do produto da concepção antes de 37 semanas de idade gestacional e é responsável pelas principais causas de morbidade infantil, especialmente no período neonatal. DESENVOLVIMENTO: Esse artigo revisou fontes literárias clássicas da obstetrícia e pareceres das sociedades médicas interessadas no tema e tem por finalidade trazer à luz as principais medidas farmacológicas na condução do trabalho de parto prematuro. O diagnóstico de trabalho de parto prematuro usualmente é clínico: documentação de contrações uterinas rítmicas e regulares capazes de promover a plasticidade do colo uterino (apagamento, dilatação ou ambos). A coleta detalhada da história clínica, o exame obstétrico e a pesquisa por sinais e sintomas que possam sugerir outros diagnósticos diferenciais são essenciais para o diagnóstico correto e manejo apropriado. CONCLUSÃO: Ao considerar a epidemiologia e a carga que a prematuridade exerce sobre o sistema de saúde, é de suma importância o correto diagnóstico e a datação da idade gestacional, a qual será o parâmetro para as intervenções melhor estabelecidas até o momento.
Palavras-chave: trabalho de parto prematuro; diagnóstico; manejo clínico.
ANÁLISE DE CONTAMINAÇÃO DE ABAIXADORES DE LÍNGUA PRÉ-USO EM UNIDADES BÁSICAS DE SAÚDE LOCALIZADAS EM GURUPI-TO
Authors: Maciel Lima Ana Karoline , Zvicker da Silva Débora , Lopes Alencar de Carvalho Adalberto , Esperidião Santos Segundo Ademir , Phernanddo Nolêto Arruda Hyággo , Alves dos Santos Émelin 
Published: December 2021

Introdução: Os abaixadores ou depressores de língua são instrumentos utilizados na Medicina e na Odontologia com a função de abaixar a base superior da língua permitindo a inspeção da boca e da orofaringe. Apesar da alta aplicabilidade do instrumento, não há protocolos ou uma padronização para seu armazenamento e/ou manipulação. Objetivo: Verificar a presença de contaminação por bactérias em abaixadores de língua pré-uso em Unidades Básicas de Saúde (UBS) do Município de Gurupi, no estado do Tocantins. Métodos: Trata-se de um estudo primário, analítico, observacional, transversal e de prevalência. Resultados: Foram coletados 66 abaixadores de língua em todos os consultórios médicos de todas as UBS’s dessa urbe. Em todas as UBS’s houve pelo menos uma positivação de teste microbiológico em meio Ágar-Sangue, sendo que em nenhuma se verificou a positivação do teste em meio MacConkey. Os abaixadores encontravam-se em diversas condições de armazenamento. Discussão: Verificou-se a presença de contaminação de abaixadores de língua por bactérias em todas as UBS’s pesquisadas, sendo que o crescimento microbiano nas placas de Ágar Sangue e não nas de Ágar MacConkey pode sugerir a presença de enterococos e estafilococos. A identificação de tais patógenos e de seu potencial iatrogênico constitui campo de pesquisa para estudos posteriores. Conclusão: Os abaixados de língua são uma ferramenta amplamente utilizada na prática clínica, no entanto, a presença de contaminação bacteriana nos mesmos pode sugerir a necessidade de criação de novos protocolos de armazenamento para prevenir que a utilização desses instrumentos corresponda a um ato iatrogênico.
Palavras-chave: Contaminação de Equipamentos; Bactérias; Doença Iatrogênica; Consultórios Médicos.
MALACOPLAQUIA VESICAL, UM RELATO DE CASO
Authors: Bezerra Rafael , Plínio da Cunha Leal  , Ed Carlos Rey Moura  , Caio Marcio Barros de Oliveira  , Vinicius de Oliveira Wallim  , Benito Júnior Santos da Costa  
Published: December 2021

Introdução: A Malacoplaquia é uma doença rara de característica inflamatória crônica, de diagnóstico histológico por achado de corpos de Michaelis-Gutmann. A apresentação macroscópica é de placas de consistência amolecida, coloração amarelada, com importante hiperemia na base da lesão. Relato de caso: Paciente portadora de doença renal crônica, com enxerto renal recebido de doador falecido, realizando terapia imunossupressora. Durante consulta no terceiro ano após o transplante realizou ultrassonografia de vias urinárias com achado de bexiga de moderada repleção, com formações nodulares sólidas lobuladas de aspecto vegetante em assoalho e parede lateral direita, medindo 2,1 x 0,6 e 1,3 x 0,4 cm, respectivamente, acompanhado de debris na cavidade vesical. A paciente foi submetida a cistoscopia transuretral com biópsia das lesões que tiveram diagnóstico histopatológico de Malacoplaquia. Foi realizada nova cistoscopia transuretral para remoção das lesões após tratamento de cistite bacteriana com Meropenem. A paciente encontra-se atualmente sem queixas e aguarda nova cistoscopia para avaliar se houve retorno das lesões. Conclusão: Existem poucos casos relatados de Malacoplaquia em pacientes que realizaram transplante renal. Com este relato, os autores pretendem descrever um caso em que foi adotada a conduta cirúrgica como abordagem terapêutica e delinear algumas considerações urológicas sobre esta patologia.
Palavras-Chave: Malacoplaquia; transplante renal; imunossupressão; infecção urinária
Komunikasi Informasi dan Edukasi (KIE) pada Santri tentang Peningkatan Imunitas untuk Pencegahan COVID-19
Authors: Lina Nur , Novianti Siti , Setiyono Andik , Setialesmana Depi 
Published: December 2021

<p align="justify"><strong>Pendahuluan:</strong><strong> </strong>Corona virus Disease 2019 (Covid-19) adalah penyakit yang disebabkan SARS-CoV-2. Muncul Klaster Covid-19 di Pesantren Kota Tasikmala. Hal hal yang meningkatkan risiko penularan Covid-19 di pondok pesantren di antaranya, satu kamar diisi lima sampai belasan santri sehingga menyulitkan prinsip jaga jarak yang menjadi bagian protokol kesehatan. Tujuan kegiatan Pengabdian Masyarakat Skema Kesehatan (PbM-SK) adalah mencegah Covid-19 di Pesantren melalui kegiatan Komunikasi Informasi dan Edulasi (KIE) pada Santri tentang Peningkatan Imunitas untuk Pencegahan Infeksi Covid-19.</p><p align="justify"><strong>Metode</strong><strong>:</strong> Metode PbM-SK yang digunakan adalah pemberdayaan masyarakat pesantren melalui KIE yang dilakukan pada dua mitra yaitu Pesantren Persis Benda 66 dan Pesantren Ibadurrahman. Kegiatan KIE di Pesantren Benda 66 dilakukan pada tanggal 28 Juli 2021 dengan jumlah peserta sebanyak 150 orang sedangkan kegiataan di Pesantren Ibadurrahman dilaksanakan pada tanggal 16 Agustus 2021 dengan jumlah peserta sebanyak 30 orang.</p><p align="justify"><strong>Hasil dan pembahasan</strong>: Pemberian KIE tentang peningkatan imunitas untuk pencegahan Covid-19 di Pesantren Ibadurrahman dilaksanakan pada siswa MTs dan MA putra dan putri yang dilaksanakan bersamaan dengan kegiatan TOP (Taaruf Orientasi Pesantren) pada santri baru kelas satu. Pengelola pesantren didorong terlibat pro aktif dan berkoordinasi dengan pelayanan kesehatan dalam pemberian vaksinasi pada santri. Kedua mitra diberikan Kit Pencegahan Covid-19 yaitu masker kain, masker bedah, hand sanitizer, oksimeter, vitamin C. Diberikan juga banner sebagai media edukasi, untuk menjadi pengingat agar tetap patuh protokol kesehatan.</p><p align="justify"><strong>Kesimpulan:</strong> Pelaksanaan KIE berjalan dengan lancar, peserta menyimak dengan antusias. Telah disampaikan alat kesehatan berupa masker kain dan masker bedah, hand sanitizer dan oksimeter dan Vitamin.<strong></strong></p>
Run-off and Soil Loss Estimation Using Numerical Approach in Hard Rock Terrain.
Authors: Pandey Hemant Kumar , Singh Vishal , Singh Ram Pal 
Published: December 2021

Abstract
The present study reveals the potential run-off estimation, soil erosion and scope of groundwater recharge in the Bundelkhand region in the state of U.P. , India. The estimation of run-off and soil erosion have provided a platform to evaluate the realistic potential for water conservation in the study area. The study area is characterized by occurrence of mild to severe drought conditions with significant run-off and poor infiltration. Geomorphological factors such as land use changes, slope, and nature of soil affect the run-off rate and discharge significantly. Soil map and rainfall data for the study area were acquired to evaluate the hydrological soil group (HSG) and antecedent moisture condition (AMC) respectively. Soil Conservation Services and Curve Number (SCS-CN) method has been used to calculate the run-off volume at the point where river/streams join together while soil loss has been calculated using revised universal soil loss equation of RUSLE model with the input of spatial data sets such as soil texture, rainfall, topography etc. The maximum run-off (355mm) has been estimated in watershed-1 during 2016 and minimum (1 mm) in watershed-4 respectively. The estimated run-off varies from 5.5% to 28% of the total rainfall in the study area, while soil loss is maximum (2.1x106 ton/ha) in the watershed-1. It is a fact that soil loss is in conformity with run-off. This finding provides the roadmap for the selection of suitable artificial recharge structures to augment the groundwater in the study area.
Selective Outcome Reporting (SOR) in Pediatric Dentistry restorative treatment randomized clinical trials - A meta-research.
Authors: Elagami Rokaia Ahmed , Tedesco Tamara Kerber , Pannuti Claudio Mendes , Silva Gabriela Seabra da , Braga Mariana Minatel , Mendes Fausto Medeiros , Raggio Daniela P 
Published: December 2021

Abstract
BackgroundSelective outcome reporting (SOR) is a type of bias that occurs when the primary outcome of a randomized clinical trial (RCT) is omitted or changed prospectively. We evaluated the prevalence of SOR in RCTs on restorative caries treatment in primary teeth.MethodsWe conducted an electronic search on ClinicalTrials.gov and the World Health Organization (WHO) platform up to April/2021. We included RCT protocols that tested restorative treatments in primary teeth and excluded any protocol that has not resulted in at least one publication in a peer-reviewed scientific journal. The Chi-square test was used to detect the association between SOR and other variables (α = 5%).ResultsOut of 294 potential protocols, thirty were included. We found 34 corresponding publications and had the one that seemed to report the primary outcome and longest follow-up, resulting in 30 publications. SOR was observed in 53.3% (n=16) of the published trials and was significantly associated with the discrepancy in the follow-up period (p=0.017).ConclusionThere is a considerable prevalence of selective outcome reporting (SOR) on restorative trials in primary teeth. Properly pre-registered protocols and assessing them for the peer review processes will help decrease SOR.Practical implicationsRestorative treatment trials in primary teeth that selectively modify outcomes of interest have been shown to distort the treatment effect. Practitioners should avoid using restorative treatments based on misleading results in clinical practice.
Sexual Function, Self-Esteem, and Quality of Life in Infertile Couples Undergoing In Vitro Fertilization: A Dyadic Approach
Authors: wang Jieyu , Lv Xiaoqing , Wu Jingmei , Tang Wangqin , Wang Danni , Luo Guiying , Hong Jingfang , Cao Yunxia 
Published: December 2021

Abstract
Background: Infertility can be characterized as a situation of dyadic stress because it affects both individuals and their partners. Previous studies have shown that infertile couples have a poorer quality of life (QoL). However, the impact of sexual function on couples’ QoL and the potential mediating role of self-esteem during in vitro fertilization is unexplored. Our study aimed to investigate the relationship between sexual function and QoL in couples with infertility through mediation of self-esteem at the dyadic level. Methods: In this descriptive cross-sectional study, 428 infertile couples (856 individuals) undergoing in vitro fertilization (IVF) were recruited from the First Affiliated Hospital of Anhui Medical University in China between October 2020 and January 2021. We assessed sociodemographic and clinical characteristics, sexual function, self-esteem, and QoL of the dyads. Dyadic data were analyzed using the Actor-Partner Interdependence Mediation Model approach (APIMeM). Results: The APIMeM analysis indicated that the sexual function of infertile wives and husbands was positively correlated with their individual QoL, directly or indirectly, mediated by increasing their personal self-esteem. The wives’ sexual function was positively correlated with their husbands’ QoL, directly or indirectly, mediated by increasing the wives’ self-esteem. There were partial mediating and masking effects of the wives’ self-esteem on the relationship between their husbands’ sexual function and wives’QoL and their husbands’ sexual function and their own QoL. Conclusions: The results suggest that improving infertile husbands’ and wives’ sexual function can improve the QoL for both the individual and the partner; improving the husbands’ self-esteem can improve the husbands’ own QoL, while improving the wives’ self-esteem can improve the QoL for both themselves and their husbands. Therefore, sex therapy and psychological interventions that strengthen self-esteem should treat the couple as a unit in the context of infertility.
Heterogeneous Environmental Regulations And Green Economic Efficiency In China: The Mediating Role of Industrial Structure
Authors: Wang Guimei , Cheng Kaiming , Luo Yusen , Salman Muhammad 
Published: December 2021

Abstract
As the largest emerging economy, China has been experiencing significant environmental problems. To sustain green economic efficiency and modernize industrial structure, China has devised several environmental regulations. While, previous studies have obtained insightful conclusions on this subject, others have presented the reverse arguments, thereby leaving gaps in the literature. This study therefore analyzes the effects of heterogeneous environmental regulations on green economic efficiency in China while taking industrial structure as a mediator over the period 2003-2017. The green economic efficiency was estimated through slacks-based direction distance function (SBM-DDF) model which considers slacks and avoids overestimation. The results of dynamic panel two-stage system generalized method of moments (GMM) show that control-and-command regulation, market-based regulation and voluntary regulation are conducive to China’s green economic efficiency. Regarding spatial heterogeneity, control-and-command and voluntary regulations significantly promote green economic efficiency of inland provinces while the effect is insignificant in coastal provinces. Additionally, market-based regulation promotes green economic efficiency by advanced and rationalized industrial structure. Control-and-command regulation accelerates green economic efficiency only through advanced industrial structure. Voluntary regulation yields positive effect on green economic efficiency through advanced industrial structure and negative effect through rationalized industrial structure. Finally, a number of policy implications are provided.
KCNH2 Regulates the Growth and Metastasis of Pancreatic Cancer
Authors: Zhou Bin , Lei Jinghao , Wang Qiang , Qu Tengfei , Cha Lichao , Zhan Hanxiang , Xu Jianwei , Liu Shanglong , Tian Lantian , Sun Chuandong , Cao Jingyu , Qiu Fabo , Guo Weidong 
Published: December 2021

Abstract
The mortality rate of pancreatic cancer (PC) remains high due to late diagnosis, early metastasis, and difficulty of complete resection. The online databases showed that potassium voltage-gated channel subfamily H member 2 (KCNH2) was highly expressed in pancreatic tumor tissues and was closely related to the poor survival of patients with PC. However, the mechanism of action of KCNH2 in PC is still unclear. In the present study, for the first time, we explored the regulatory effect of KCNH2 in PC. The results showed that KCNH2 was upregulated in PC compared with normal pancreatic tissues. High KCNH2 expression was associated with low tissue differentiation, high malignancy, and poor prognosis of PC. Moreover, knockdown of KCNH2 inhibited the proliferation and apoptosis of PC cells, as well as the epithelial-mesenchymal transition process, thereby promoting PC cell migration and invasion. In addition, KCNH2 knockdown inhibited the progression and metastasis of PC in a mouse xenograft model. In conclusion, these findings highlighted the potential of KCNH2 as a targeted molecule in the treatment of PC.
Priming Effect of Exogenous ABA on Heat Stress Tolerance in Rice Seedlings is Associated with the Upregulation of Antioxidative Defense Capability and Heat Shock-Related Genes
Authors: Liu Xiaolong , Ji Ping , Yang Hongtao , Jiang Changjie , Liang Zhengwei , Chen Qizhou , Lu Fang , Chen Xin , Yang Yunyun , Zhang Xiaobo 
Published: December 2021

Abstract
Heat stress is a major restrictive factor that suppresses rice production. In this study, we investigated the potential priming effect of exogenous abscisic acid (ABA) on heat tolerance in rice seedlings. Seedlings were pretreated with 10 μM ABA by root drenching for 24 h and then subjected to heat stress conditions of 40 °C day/35 °C night. ABA pretreatment significantly decreased leaf withering by 2.5– 28.5% and chlorophyll loss by 12.8–35.1% induced by heat stress in rice seedlings. ABA application also mitigated cell injury, as shown by lower malondialdehyde (MDA) content, membrane injury and expression of cell death-related genes OsKOD1 , OsCP1 and OsNAC4 , while expression of OsBI1 , a cell death-suppressor gene, was upregulated by ABA pretreatment. Moreover, ABA pretreatment improved antioxidant defense capacity, as shown by an obvious upregulation of ROS-scavenging genes and a decrease in ROS content (O 2 – and H 2 O 2 ) and downregulation of the OsRbohs gene. The application of fluridone, an ABA biosynthesis inhibitor, increased membrane injury and the accumulation of ROS under heat stress. Exogenous potent antioxidants (proanthocyanidins, PC) significantly alleviated leaf withering by decreasing ROS overaccumulation and membrane injury induced by heat stress. In addition, ABA pretreatment significantly superinduced the expression of ABA-responsive genes SalT and OsWsi18 , the ABA biosynthesis genes OsNCED3 and OsNCED4 , and the heat shock-related genes OsHSP23.7 , OsHSP17.7 , OsHSF7 and OsHsfA2a . Taken together, these results suggest that exogenous ABA has a potential priming effect for enhancing heat stress tolerance of rice seedlings mainly by improving antioxidant defense capacity and heat shock-related genes.
Ginsenoside Rg3 Induces Apoptosis and Inhibits Proliferation By Down-Regulating TIGAR in MNNG-Induced Gastric Precancerous Lesions in Rats
Authors: Lv Shangbin , Chen Xiaodong , Mao Gang , Gong Daoyin , Chen Yu , Xia Ting , Cheng Jing , Luo Zhaoliang , Cheng Yu , Zeng Jinhao , Li Weihong 
Published: December 2021

Abstract
BACKGROUND

Ginsenoside Rg3 (GRg3) is one of the main active ingredients in Chinese ginseng extract and has various biological effects, such as immune-enhancing, antitumour, antiangiogenic, immunomodulatory and anti-inflammatory effects. This study aimed to investigate the therapeutic effect of GRg3 on gastric precancerous lesion (GPL) induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and the potential mechanism of action.
METHODS

The MNNG–ammonia composite modelling method was used to establish a rat model of GPL. Histopathological changes in the rat gastric mucosa were observed by pathological analysis using haematoxylin–eosin staining to assess the success rate of the composite modelling method. Alcian blue–periodic acid Schiff staining was used to observe intestinal metaplasia in the rat gastric mucosa. Apoptosis was detected in rat gastric mucosal cells by terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling staining. The expression level of reactive oxygen species (ROS) was determined by the dihydroethidium fluorescent probe method, and that of TP53-induced glycolysis and apoptosis regulator (TIGAR) protein was determined by immunohistochemical staining and western blotting. The expression levels of nicotinamide adenine dinucleotide phosphate (NADP) and glucose-6-phosphate dehydrogenase (G6PDH) were determined by an enzyme-linked immunosorbent assay, and that of glutathione (GSH) was determined by microanalysis.
RESULTS

GRg3 significantly alleviated the structural disorganization and cellular heteromorphism in the form of epithelial glands in the gastric mucosa of rats with GPL and retarded the progression of the disease. Overexpression of TIGAR, NADP, GSH and G6PDH occurred in the gastric mucosal epithelium of rats with GPL, which in turn led to an increase in the ROS concentration. After treatment with GRg3, the expression of TIGAR, NADP, GSH and G6PDH decreased, causing a further increase in the concentration of ROS in the gastric mucosal epithelium, which in turn induced apoptosis and played a role in inhibiting the abnormal proliferation and differentiation of gastric mucosal epithelial cells.
CONCLUSION

Grg3 can induce apoptosis and inhibit cell proliferation in MNNG-induced GPL rats. The mechanism may be related to down regulating the expression levels of TIGAR, GSH, NADP and G6PD, up regulating the concentration of ROS and inducing apoptosis.