bluuebunny/crossref_metadata_2025_split huggingface dataset:
Évolution du jardin latin moderne », dans Du paradis au jardin latin
Authors: Rubió y Tudurí Nicolás Marías 
Published: December 2021

L’architecte paysagiste Nicolás Marías Rubió y Tudurí naît en 1891 à Minorque. À Barcelone, où il fait ses études, il rencontre Jean Claude Nicolas Forestier avec qui il collabore pour l’aménagement des jardins de Montjuich. Il enseigne l’art des jardins, de 1916 à 1924, à l’Escola de Bells Oficis de Catalogne. En 1917, il est nommé directeur des parcs publics de Barcelone. Puis, pendant la seconde République, il devient responsable du Service de planification urbaine de Catalogne. Peu connue en France, l’œuvre de Nicolás Marías Rubió y Tudurí se partage entre l’architecture, la réalisation de parcs et l’écriture. C’est ainsi qu’il publie Del paraíso al jardín latino, vaste synthèse d’histoire des jardins. Il se propose de montrer comment l’essence du jardin latin ou, mieux, le jardin de la latinité se déploie à travers le temps et innerve tous les autres styles de composition. Dans l’« Evolución del jardín latino moderno », qui constitue le dernier chapitre de cet ouvrage, il traite de l’histoire des jardins de la Renaissance italienne à l’époque moderne. Nous espérons que la traduction de ce passage contribuera à faire connaître, en France, l’œuvre de cet architecte paysagiste et qu’elle ne trahira pas le lyrisme du texte espagnol.
A complex unit for a complex disease: the HCM-Family Unit
Authors: Vriz Olga , AlSergani Hani , Elshaer Ahmed Nahid , Shaik Abdullah , Mushtaq Ali Hassan , Lioncino Michele , Alamro Bandar , Monda Emanuele , Caiazza Martina , Mauro Ciro , Bossone Eduardo , Al-Hassnan Zuhair N. , Albert-Brotons Dimpna , Limongelli Giuseppe 
Published: December 2021

Hypertrophic cardiomyopathy (HCM) is a group of heterogeneous disorders that are most commonly passed on in a heritable manner. It is a relatively rare disease around the globe, but due to increased rates of consanguinity within the Kingdom of Saudi Arabia, we speculate a high incidence of undiagnosed cases. The aim of this paper is to elucidate a systematic approach in dealing with HCM patients and since HCM has variable presentation, we have summarized differentials for diagnosis and how different subtypes and genes can have an impact on the clinical picture, management and prognosis. Moreover, we propose a referral multi-disciplinary team HCM-Family Unit in Saudi Arabia and an integrated role in a network between King Faisal Hospital and Inherited and Rare Cardiovascular Disease Unit-Monaldi Hospital, Italy (among the 24 excellence centers of the European Reference Network (ERN) GUARD-Heart).

Graphical Abstract
Quality of Care for Patients with Acute Coronary Syndrome
Authors: Zhao Dong , Smith Sidney C. 
Published: December 2021

Abstract
Acute coronary syndrome (ACS) is a severe clinical manifestation of ischemic heart disease with a high risk of death. The quality of care provided by the health system and medical providers to patients with ACS in daily clinical practice determines the likelihood of desired health outcomes or prognosis. This review provides an overview of several key issues in the quality of care for ACS, including how to measure the quality of care for ACS and the main strategies to improve the quality of care for ACS patients in both the acute and chronic phases. Efforts to improve the quality of care for ACS through specific programs in Western countries and in China are also described.
Study of Laboratory Parameters in COVID-19 Patients at a Tertiary Care Teaching Hospital in Uttar Pradesh
Authors: Puri Sarandeep Singh , Singhal Parul , Singhal Seema 
Published: December 2021

Introduction:
COVID-19 infection has been affecting vast population all over the world since 2019. It is very important to make optimum use of routine laboratory parameters in evaluating severity of COVID-19 disease. This will help the clinicians to improve allocation of technical human resources to patients who require it the most. During the path of the COVID-19 disease, inflammatory indices such as lactate dehydrogenase (LDH), C-reactive protein (CRP), interleukin-6 (IL-6), biomarkers like serum procalcitonin (PCT), and ferritin and indices of coagulation profile like D-Dimer, PT levels, and hematological parameters like total leukocyte count, platelets carry prognostic value. The objective of the study is to estimate the utility of various laboratory Biochemical and Hematological parameters in COVID-19 disease.

Materials and Methods:
The present study is a retrospective cross-sectional observational study conducted in tertiary care rural teaching hospital. The study was conducted from September 1, 2020, to January 31, 2021. The study was carried out on the patients who were hospitalized in Isolation Ward and COVID ICU in our L3 COVID hospital. All patients with positive SARS-CoV-2 nucleic acid test results were included in the study. A sample size of 310 patients was taken. The basic demographic details were collected from the admission records. The confirmatory test for SARS-CoV-2 was done using the WHO-approved kits based on real-time reverse transcription polymerase chain reaction for which suspected cases underwent nasopharyngeal/oropharyngeal swab testing. The levels of CRP, IL-6, PCT, ferritin LDH, D-dimer, complete blood counts, PT were based on standardized methods obtained using various biochemical and hematological laboratory analyzers. Data of investigation reports were gathered from electronic patient record system. Statistical analysis was performed using the Statistical Package for the Social Sciences for Windows (version 25.0).

Results:
Our study clearly shows that levels of IL-6, D Dimer, PT, and LDH are quite significantly raised in majority of patients while PCT and ferritin being somewhat nonspecific show an increase but not to that significant numbers. The hematological parameters show levels which indicate mild anemia, leukocytosis, neutrophilia, lymphopenia, and thrombocytopenia in patients infected with COVID-19 disease.

Conclusion:
COVID-19 is an unexplored, new entity with a sudden worldwide onset. The medical fraternity is yet to conquer and analyse this novel virus.
Cytological Grading of Prostate Carcinoma
Authors: Kala Chayanika , Bajpai Ashutosh , Kala Sanjay , Khan Lubna 
Published: December 2021

Introduction:
The Gleason grading system is one of the most powerful prognostic predictors of carcinoma prostate. In 2014, a newer grading system, the International Society of Urologic Pathology (ISUP) grading system was proposed. The present study is a retrospective study conducted to compare the cytological grading of prostate carcinoma with the newly proposed ISUP grading system for prostate carcinoma.

Materials and Methods:
The present study is a retrospective study that included 42 cases of carcinoma prostate. The clinical data of the cases, fine-needle aspiration cytology slides, and histological slides were retrieved and reviewed. The cases were regraded using the ISUP grading system for prostate carcinoma. Statistical analysis was done using the Statistical Package for the Social Sciences (SPSS). Data were statistically analyzed and Chi-square testing was used to compare the two grading systems.

Results:
A total of 42 cases were studied. The preoperative grade was assigned to the smears and 26.19% (11 cases) were categorized as grade 1, 40.47% (17 cases) as grade 2, and 33.3% (14 cases) as grade 3. Histological sections were also graded according to the ISUP/grade groups (GG) system and 26.19% (11 cases) were graded as GG 1, 33.3% (14 cases) as GG2, 19.04% (8 cases) as GG3, 16.67% (7 cases) as GG4, and 4.47% (2 cases) as GG5.

Conclusion:
In the present study, it was concluded that there is a direct concordance between the histologic grade as proposed in the ISUP grading system and the cytologic grade on FNA.
The Impact of Interaction with Orphanage Children on Quality of Life of Elderly Females Residing in Old-Age Homes in a South Indian District
Authors: Jeeragyal Devika Pandurang , Udayar Sharvanan Eshwar , Annadani Rachana R , Undi Malatesh 
Published: December 2021

Introduction:
Improving the quality of life (QOL) of the elderly has been one of the crucial challenges of public health with increasing life expectancy. The study was done to assess the impact on QOL and psychiatric morbidities among elderly females in old age homes (OAH) who had interaction with orphanage children.

Materials and Methods:
An analytical cross-sectional study was conducted among 105 elderly females who were residing in OAHs in Chittoor District, India, from Sep–Dec 2019. Data were collected using older people's QOL scale, Hamilton's Scales (HAM-A and HAM-D). Ethical approval was obtained from the Institutional Ethics Committee. Data were analyzed using the Statistical Package for the Social Sciences (SPSS), software version 20.

Results:
About 82.9% of elderly females in OAHs who were interacting with orphanage children had good QOL when compared to those who were not (8.6%). A significant difference was observed in domains scores for overall life, independent home and neighborhood, psychological and emotional well-being, and religion in the elderly who were interacting with orphanage children when compared to those who did not. Mean scores for depression and anxiety were significantly higher (P = 0.001) in those who were not interacting with the orphanage children (23.23, 43.74) than with interaction (13.46, 43.74).

Conclusions:
Overall QOL was better in elderly females who had interaction with orphanage children when compared to those who did not. Furthermore, psychiatric morbidities (depression and anxiety) were significantly higher in those who were not having interaction with orphanage children than those with interaction (P = 0.001).
A Comparative Analysis of Live-Related ABO-Incompatible and ABO-Compatible Renal Transplantation
Authors: Yachha Monika , Sharma Raj Kumar , Mehrotra Sonia , Prasad Narayan , Gupta Amit , Bhadauria Dharmendra S. , Kaul Anupama 
Published: December 2021

Background:
ABO incompatible (ABOi) transplantation is a relatively newer option for renal transplant. Despite the encouraging results and the presence of organ shortage, it is still not routine in many developing countries. This can be attributed to the lack of experience, lack of technical infrastructure, and financial limitations.

Objectives:
Our study aimed to compare the outcomes of living-donor ABOi renal transplantation with matched recipients of ABO-compatible (ABOc) transplantation. We also assessed the impact of Vitamin D deficiency on posttransplant outcomes in terms of graft function and rejections in these groups.

Methods:
We retrospectively analyzed the results of 33 ABOi living-donor kidney transplants performed between January 2013 and June 2016 at our center. We compared patient and graft survival, acute rejection episodes, Vitamin D status, and graft function of the ABOi group with an equal number of matched live-related ABOc KTs done during the same time period.

Results:
The patient survival in both the groups was 97%; however, death-censored graft survival was 94% in the ABOi recipients versus 100% in ABOc group over a mean follow-up of 14–15 months, respectively. Graft function was overall better in the ABOc recipients, with statistical significance seen at 6 and 12 months posttransplant. We also observed a significantly higher incidence of acute antibody-mediated rejections (ABMRs) in the ABOi cohort, with 11 episodes of ABMR versus just 2 in the ABOc recipients (P = 0.005). Vitamin D deficiency was associated with higher levels of anti-ABO antibody and increased development of ABMR due to anti-ABO antibodies (P = 0.01).

Conclusions:
ABO incompatible transplantation is an option with excellent patient and graft survival; results almost comparable to the ABO compatible grafts. However, in our study, ABOi transplants were associated with higher risk of acute ABMR. These episodes were amenable to treatment, and thus, the overall graft survival had similar outcomes. Vitamin D deficiency was associated with increased ABMR in ABOi cohort of renal transplantation.
COVID-19–Associated Rhino-Orbital-Cerebral Mucormycosis
Authors: Bhattacharyya Anusuya , Sarma Phulen , Kaur Hardeep , Kumar Subodh , Bhattacharyya Jaimini , Prajapat Manisha , Prakash Ajay , Sharma Saurabh , Reddy Dibbanti Harikrishna , Thota Prasad , Bansal Seema , Gautam Bhaswati Sharma , Medhi Bikash 
Published: December 2021

BACKGROUND:
Till now, no meta-analysis is available to address the clinical profile, risk factors, different interventions, and outcomes among COVID-19–associated rhino-orbito-cerebral mucormycosis (C-ROCM) cases.

MATERIALS AND METHODS:
Eight literature databases were screened using appropriate keywords from November 1, 2019, to June 30, 2021. The objectives were to analyze the clinical and microbiological profile, risk factor/comorbidity, intervention, and outcome. “R-metafor package” was used for analysis.

RESULTS:
A total of 23 studies were included. The mean age of presentation of C-ROCM was 54.6 years. The most common presentation was ptosis (72.7%), lid edema (60.6%), proptosis (60.6%), ophthalmoplegia (57.3%), loss of vision (53.7%), facial edema (34.7%), and nasal-blockage (11.8%). Evidence of intracranial spread was seen in 42.8% of cases. Rhizopus was the most common fungus (57.1%) isolated in fungal culture. Among C-ROCM patients, diabetes was the commonest comorbid condition, and the use of corticosteroids related to COVID-19 treatment was the most common risk factor (85.75%). Compared to controlled diabetics, C-ROCM was significantly higher among uncontrolled diabetics (odds ratio [OR] 0.15, 95% confidence interval [C.I.] 0.041–0.544, P = 0.0010). However, no significant association was seen between C-ROCM and COVID-19 severity (OR 0.930, 95% C.I. 0.212–4.087, P = 0.923). For treatment, amphotericin-B was the most common antifungal drug used which was followed by surgical options. However, mortality was high (prevalence 0.344, 95% C.I. 0.205–0.403) despite treatment.

CONCLUSION:
Although local rhino-orbito symptoms were the first to appear, rapid intracranial extension was seen in a significant number of C-ROCM cases. Uncontrolled diabetes and excessive use of corticosteroid were the most common risk factors present among the C-ROCM cases. High index clinical suspicion is imperative (specifically among COVID-19 patients with diabetes), and routine screening may be helpful.
Pharmacodynamic and pharmacokinetic interaction of losartan with glimepiride-metformin combination in rats and rabbits
Authors: Nagaraju Beere , Anilkumar KV 
Published: December 2021

OBJECTIVES:
The presence of comorbidities such as cardiovascular disease, peripheral vascular disease, and chronic renal disease, or and the prevention of these ailments in diabetics, frequently demands multiple drug treatments, increasing the risk of drug-drug interactions (DDIs). The current study was focused on identifying possible DDIs on concomitant administration of losartan, a drug used to regulate hypertension along with a combination of glimepiride + metformin, widely used to treat diabetes mellitus. Possible pharmacodynamic and pharmacokinetic interactions were observed for, following single-dose as well as multiple-dose treatment protocols in normal and alloxan-induced diabetes in albino Wistar rats and rabbits.

MATERIALS AND METHODS:
Blood samples from surviving rats/rabbits obtained through orbital venous sinus bleeding/marginal ear vein bleeding, respectively, at predetermined intervals and put through to biochemical estimations of sugar level in the blood by Glucose oxidase/peroxidase method; insulin levels in serum using the enzyme-linked immunosorbent assay and serum glimepiride levels using the high-performance liquid chromatography.

RESULTS AND DISCUSSION:
Losartan, when treated as a single drug, resulted in a slight lowering of blood glucose levels in normal rats, diabetic rats and normal rabbits. Hypoglycemic activity of a combination of glimepiride + metformin was enhanced when losartan was co-administered as a single dosage schedule as well as a multiple dose schedule as indicated by a reduced blood glucose level and enhanced levels of insulin in rats as well as in rabbits. Serum glimepiride levels were also higher and pharmacokinetic parameters of glimepiride including mean residence time, Cmax, T1/2, AUMC0-∞, AUMC0-t, and AUC0-∞, were significantly higher, whereas its clearance was decreased in the two regimens of losartan that was followed.

CONCLUSION:
It can therefore be concluded, that in diabetics with hypertension as a comorbidity condition, co-administration of losartan with glimepiride + metformin should be avoided or the dosage of a combination of glimepiride + metformin needs to be tittered to avoid recurrence of hypoglycemic episodes.
Age at Natural Menopause; A Data Mining Approach (Data from the National Health and Nutrition Examination Survey 2013-2014)
Authors: Alinia Tahereh , Khodakarim Soheila , Tehrani Fahimeh Ramezani , Sabour Siamak 
Published: December 2021

Background:
The timing of the age at which menopause occurs varies among female populations. This variation is attributed to genetic and environmental factors. This study aims to investigate the determinants of early and late-onset menopause.

Methods:
We used data from the National Health and Nutrition Examination Survey 2013-2014 for 762 naturally menopause women. Data on sociodemographic, lifestyle, examination, and laboratory characteristics were examined. We used random forest (RF), support vector machine (SVM), and logistic regression (LR) to identify important determinants of early and late-onset menopause. We compared the performance of models using sensitivity, specificity, Brier score, and area under the receiver operating characteristic (AUROC). The top determinants were assessed by using the best performing models, using the mean decease in Gini.

Results:
Random forest outperformed LR and SVM with overall AUROC 99% for identifying related factors of early and late-onset menopause (Brier score: 0.051 for early and 0.005 for late-onset menopause). Vitamin B12 and age at menarche were strongly related to early menopause. Also, methylmalonic acid (MMA), vitamin D, body mass index (BMI) were among the top highly ranked factors contributing to early menopause. Features such as age at menarche, MMA, sex hormone-binding globulin (SHBG), BMI, vitamin B12 were the most important covariate for late-onset menopause.

Conclusions:
Menarche age and BMI are among the important contributors of early and late-onset menopause. More research on the association between vitamin D, vitamin B12, SHBG, and menopause timing is required which will produce invaluable information for better prediction of menopause timing.
Effect of left nostril breathing on postexercise recovery time
Authors: Jyothish U. Karthika , Das Subhasis 
Published: December 2021

Background:
The nasal cycle is the alternating congestion and decongestion of the nostrils during normal breathing, marking the shift between the sympathetic and parasympathetic systems, the latter being prominent when breathing through the left nostril. The post-exercise period is characterized by a gradual shift from sympathetic to parasympathetic dominance. It is hypothesized that breathing only through the left nostril will aid in accelerating this shift in the postexercise period.

Objectives:
The objective of this study is to assess the effect of left nostril breathing on post-exercise recovery times of heart rate and blood pressure (BP).

Materials and Methods:
A total of 60 young healthy male volunteers were instructed to walk on a flat treadmill, following a fixed protocol. Heart rate and BP were measured at rest and postexercise they were monitored every minute until they reached the baseline. The recovery time was noted. The procedure was the same on the 3rd day, except that during the postexercise period, the participants were instructed to breathe only through their left nostrils.

Results:
The recovery times of heart rate and BP, when breathing through the left nostril only, was significantly lower than when breathing normally.

Conclusion:
The left nostril breathing technique lowered the postexercise recovery times of cardiovascular parameters, which can be attributed to improved parasympathetic tone. These findings on the post-exercise state may be extrapolated to pathological states of sympathetic dominance, and left nostril breathing can be used as an adjunct to pharmacological therapy to manage such conditions.
Level of stress among postgraduate junior residents during their postgraduation in medical colleges of Coastal Karnataka – A cross-sectional study
Authors: Bhat Madhavi , Nafisa Dilshana , Kakunje Anil , Mithur Rajesh , Karkal Ravichandra 
Published: December 2021

Background:
Stress has been an unavoidable reality of resident's life. Postgraduates face numerous stressors in their medical training. Stress may indirectly lead to medical errors which negatively impact the quality of patient care. However, the severity varies among individuals. Here, we present a study where we looked into the levels of stress among postgraduate junior residents of Coastal Karnataka and its association with various sociodemographic and clinical variables.

Materials and Methods:
This cross-sectional study conducted among postgraduate residents of various departments of seven medical colleges of Coastal Karnataka involved 236 participants. Ethical clearance was obtained from the institutional ethical committee. The sociodemographic and clinical variables of participants were collected using an online questionnaire. Assessment of stress level was done using Perceived Stress Scale.

Results:
The study indicated statistically significant increase in stress level among females compared to males (P = 0.009). The year of postgraduation, number of years taken to join postgraduation, and subject of postgraduation did not make any significant difference in the level of stress. However, most of the postgraduates had moderate stress scale scores.

Conclusion:
Postgraduation is indeed a time of incredible stress to all the residents. Our study was also able to indicate the same. There is a need to provide psychological support during their training.
Prevalence and Factors Associated with Suicidal Behaviors in a Cross-Sectional Sample of Nigerian Young Adults
Authors: Tolulope Opakunle , Olubukola Opakunle , Olutayo Aloba 
Published: December 2021

Objective:
In this study, we intended to assess the prevalence of suicidal behaviors and their associated factors among Nigerian young adults.

Methods:
This is a cross-sectional descriptive study involving 1171 Nigerian young adults from the six geopolitical regions of Nigeria. They completed a study-specific sociodemographic questionnaire, Suicidal Behaviors Questionnaire-Revised Scale, Satisfaction with Life Scale, 10-item Drug Abuse Screening Test, Hospital Anxiety and Depression Scale, and Rosenberg Self-Esteem Scale.

Results:
The mean age ± standard deviation of the respondents was 24.92 ± 2.42 years. The lifetime suicidal ideation, plan, and attempt were 9.6%, 5.7%, and 2.6%, respectively. Of them, 7.1% had the 12-month suicidal ideation, and 4.8% were at risk of suicide attempt. Totally, 9.6% of the respondents had high suicide risk. The symptoms of depression and anxiety were present in 13.5% and 23.1% of the respondents, respectively. Suicidal behaviors among Nigerian young adults were significantly associated with dissatisfaction with life (p < 0.05), anxiety (p < 0.001), drug abuse (p < 0.001), and low self-esteem (p < 0.01).

Conclusion:
Suicidal behaviors were relatively high among Nigerian young adults, and were associated with dissatisfaction with life, anxiety, psychoactive substance use, and low self-esteem.