bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ascending arousal system promotes optimal performance through mesoscale network integration in a visuospatial attentional task
Authors: Wainstein Gabriel , Rojas-Líbano Daniel , Medel Vicente , Alnæs Dag , Kolskår Knut K. , Endestad Tor , Laeng Bruno , Ossandon Tomas , Crossley Nicolás , Matar Elie , Shine James M. 
Published: August 2021

Abstract
Previous research has shown that the autonomic nervous system provides essential constraints over ongoing cognitive function. However, there is currently a relative lack of direct empirical evidence for how this interaction manifests in the brain at the macroscale level. Here, we examine the role of ascending arousal and attentional load on large-scale network dynamics by combining pupillometry, functional MRI, and graph theoretical analysis to analyze data from a visual motion-tracking task with a parametric load manipulation. We found that attentional load effects were observable in measures of pupil diameter and in a set of brain regions that parametrically modulated their BOLD activity and mesoscale network-level integration. In addition, the regional patterns of network reconfiguration were correlated with the spatial distribution of the α2a adrenergic receptor. Our results further solidify the relationship between ascending noradrenergic activity, large-scale network integration, and cognitive task performance.
To Believe Is Not to Think: A Cross-Cultural Finding
Authors: Van Leeuwen Neil , Weisman Kara , Luhrmann Tanya Marie 
Published: August 2021

Abstract
Are religious beliefs psychologically different from matter-of-fact beliefs? Many scholars say no: that religious people, in a matter-of-fact way, simply think their deities exist. Others say yes: that religious beliefs are more compartmentalized, less certain, and less responsive to evidence. Little research to date has explored whether lay people themselves recognize such a difference. We addressed this question in a series of sentence completion tasks, conducted in five settings that differed both in religious traditions and in language: the United States, Ghana, Thailand, China, and Vanuatu. Participants everywhere routinely used different verbs to describe religious versus matter-of-fact beliefs, and they did so even when the ascribed belief contents were held constant and only the surrounding context varied. These findings support the view that people from diverse cultures and language communities recognize a difference in attitude type between religious belief and everyday matter-of-fact belief.
Teaching a Weather Forecasting Class in the 2020s
Authors: Galen Lars van , Hartogensis Oscar , Benedict Imme , Steeneveld Gert-Jan 
Published: August 2021

Abstract
We report on redesigning the undergraduate course in synoptic meteorology and weather forecasting at Wageningen University (the Netherlands) to meet the current-day requirements for operational forecasters. Weather strongly affects human activities through its impact on transportation, energy demand planning, and personal safety, especially in the case of weather extremes. Numerical weather prediction (NWP) models have developed rapidly in recent decades, with reasonably high scores, even on the regional scale. The amount of available NWP model output has sharply increased. Hence, the role and value of the operational weather forecaster has evolved into the role of information selector, data quality manager, storyteller, and product developer for specific customers. To support this evolution, we need new academic training methods and tools at the bachelor’s level. Here, we present a renewed education strategy for our weather forecasting class, called Atmospheric Practical, including redefined learning outcomes, student activities, and assessments. In addition to teaching the interpretation of weather maps, we underline the need for twenty-first-century skills like dealing with open data, data handling, and data analysis. These skills are taught using Jupyter Python Notebooks as the leading analysis tool. Moreover, we introduce assignments about communication skills and forecast product development as we aim to benefit from the internationalization of the classroom. Finally, we share the teaching material presented in this paper for the benefit of the community.
Routine Repeat Imaging of Pediatric Blunt Solid Organ Injuries Is Not Necessary
Authors: Fletcher Kelsey L. , Meagher Mitchell , Spencer Brianna L. , Morgan Madison E. , Safford Shawn D. , Armen Scott B. , Hazelton Joshua P. , Perea Lindsey L. 
Published: August 2021

Introduction Nonoperative management of hemodynamically stable patients with blunt splenic and/or hepatic injury has been widely accepted in the pediatric population. However, variability exists in the utilization and timing of repeat imaging to assess for delayed complications during index hospitalization. Recent level-IV evidence suggests that repeat imaging in children should be performed based on a patient’s clinical status rather than on a routine basis. The aim of this study is to examine the rate of delayed complications and interventions in pediatric trauma patients with blunt splenic and/or hepatic injuries who undergo repeat imaging prompted either by a clinical change (CC) or non-clinical change (NCC). Methods A 9-year (2011-2019), retrospective, dual-institution study was performed of children (0-17 years) with blunt splenic and/or hepatic injuries. Patients were grouped based on reason for repeat imaging: CC or NCC. The rate of organ-specific delayed complications and interventions was examined by reason for scan. Results A total of 307 injuries were included in the study period (174 splenic, 113 hepatic, and 20 both). Of 194 splenic injuries, 30(15.5%) underwent repeat imaging (CC = 19; NCC = 11). Of 133 hepatic injuries, 27(20.3%) underwent repeat imaging (CC = 21; NCC = 6). There was no difference in the incidence of organ-specific delayed complications between the CC and NCC groups. Of the 4 patients with complications necessitating intervention, only one was identified based on NCC. Conclusions Our data suggest routine repeat imaging is unnecessary in children with blunt splenic and/or hepatic injuries; therefore, practitioners may rely on a patient’s clinical change.
Evaluation of the effect of phenobarbital administration on the biochemistry profile, with a focus on serum liver values, in epileptic cats
Authors: Hermans Michelle , Charalambous Marios , Pakozdy Akos , Eisl-Glantschnigg Ursula , Neßler Jasmin , Van Meervenne Sofie AE , Serrano Gonçalo , Cornelis Ine , Van Ham Luc , Paepe Dominique , Broeckx Bart JG , Bhatti Sofie FM 
Published: August 2021

Objectives Phenobarbital (PB) is the most common antiseizure drug (ASD) used for the management of feline epilepsy. In dogs, PB is known to cause serum liver enzyme induction and hepatotoxicity, especially after administration long term or in high concentrations. In cats, insufficient evidence is available to draw similar conclusions. The aim of this study was to evaluate the effect of PB administration on the serum biochemistry profile of epileptic cats. As an additional objective, other adverse effects arising, related to PB treatment, were recorded. Methods Medical records of four veterinary centres were retrospectively reviewed for epileptic cats receiving PB treatment. Cats were included if they had a diagnosis of idiopathic epilepsy or structural epilepsy; a normal baseline serum biochemistry profile; at least one follow-up serum biochemistry profile; no concurrent disease or had not received medication that could possibly influence liver function or lead to serum liver enzyme induction. Alkaline phosphatase, alanine aminotransferase (ALT), aspartate transaminase and gamma-glutamyl transferase activities, and total bilirubin, bile acids, glucose, albumin, total protein, urea and creatinine concentrations before and during PB administration were recorded. PB serum concentration was also recorded, when available. Results Thirty-three cats (24 males, nine females) with a median age of 3 years (range 2 months to 12 years) met the inclusion criteria. Idiopathic or structural epilepsy was diagnosed in 25 (76%) and eight (24%) cats, respectively. The follow-up period ranged from 9 to 62 months. This study found an increase in ALT in three cats, possibly related to a PB serum concentration >30 µg/ml. No statistically significant increase in serum liver enzymes or other evaluated biochemistry parameters was found by comparing pre- and post-treatment parameters. Conclusions and relevance PB administration did not result in hepatic enzyme induction or other biochemical abnormalities in cats. This strengthens the safety profile of PB as an ASD in cats.
The effect of national disease-modifying therapy subsidy policy on long-term disability outcomes in people with multiple sclerosis
Authors: Claflin Suzi B , Campbell Julie A , Mason Deborah F , Kalincik Tomas , Simpson-Yap Steve , Norman Richard , Butzkueven Helmut , Carroll William M , Palmer Andrew J , Blizzard C Leigh , van der Mei Ingrid , Taylor Bruce V 
Published: August 2021

Background: Disease-modifying therapies (DMTs) are used to treat people with relapsing-onset multiple sclerosis (ROMS), but our knowledge is largely limited to their short-term effects. Objective: To determine (1) the impact of national-level DMT subsidy policy on DMT use and health outcomes in people with MS (PwMS) and (2) the long-term effects of DMT on disability and quality of life (QoL; 5-level EQ-5D version (EQ-5D-5L) utility value). Methods: This observational cohort study compared Australian and New Zealand populations with different levels of DMT availability 10–20 years post-ROMS diagnosis. Between-country differences were assessed using standardised differences. Associations were assessed with multivariable linear regression models. Results: We recruited 328 Australians and 256 New Zealanders. The Australian cohort had longer DMT treatment duration, greater proportion of disease course treated and shorter duration between diagnosis and starting DMT. The Australian cohort had lower median Expanded Disability Status Scale (EDSS) (3.5 vs 4.0) and Multiple Sclerosis Severity Score (MSSS) (3.05 vs 3.71) and higher QoL (0.71 vs 0.65). In multivariable models, between-country differences in disability and QoL were largely attributed to differential use of DMT. Conclusions: This study provides evidence for the impact of national-level DMT policy on disability outcomes in PwMS. Where DMTs are more accessible, PwMS experienced less disability progression and improved QoL 10–20 years post-diagnosis.
Percutaneous Treatment of Concomitant Severe Aortic Stenosis and Thoracoabdominal Aortic Aneurysm
Authors: Painchaud-Bouchard Ariane-Sophie , Potvin Jeannot , Forcillo Jessica , Ruz Ricardo , Elkouri Stephane 
Published: August 2021

Purpose: Although rare in occurrence, symptomatic severe aortic stenosis and large thoracoabdominal aortic aneurysm (TAAA) found in combination pose a real therapeutic challenge, especially in elderly frail patients. Surgical approaches for combined treatment are complex and at high risk of complications while staged procedures carry the risk of an unfavorable evolution of the condition temporarily left untreated. Minimally invasive approaches may therefore prove a more suitable strategy for these patients. Case Report: We present the case of a 78-year-old woman with symptomatic severe aortic stenosis (AS) and a TAAA of 7.8 cm in diameter. Transcatheter treatment of both conditions was successfully performed in a staged manner. The first intervention consisted of combined transfemoral transcatheter aortic valve implantation (TAVI) immediately followed by a zone 3 thoracic endovascular aortic endoprosthesis deployment. In order to reduce the extent of intercostal arteries coverage and mitigate the risk of medullar ischemia, a second-stage percutaneous endovascular treatment of the TAAA was performed with a customized 4-fenestration prosthesis. Early and 12-month clinical and radiologic follow-up were favorable. Conclusion: This case demonstrates how a strong multidisciplinary collaboration allows for successful resolution of complex clinical scenarios.
Using Online Self-Management Diaries for Qualitative Research
Authors: Saeidzadeh Seyedehtanaz , Gilbertson-White Stephanie , Kwekkeboom Kristine L. , Babaieasl Faezeh , Seaman Aaron T. 
Published: August 2021

Diaries are an underutilized tool in qualitative research addressing self-management. The “real time” data offered by the diaries provide an opportunity to capture details of self-management that otherwise may be missed during an interview. The purpose of this study is to describe the feasibility of using diaries for capturing self-management of post-treatment cancer survivors. The research questions are (1) how did participants engage with the diary? (2) what were participants’ evaluations of the self-management diary? and (3) how did the use of self-management diaries affect qualitative interviews and the interview data collected? We conducted a qualitative descriptive study, which comprised diary and semi-structured interview components to explore cancer survivors’ self-management activities. Participants were individuals diagnosed with head and neck or colorectal cancers at ages ≥18 years old who had completed primary treatment between 2–10 years prior. The diary instructions directed participants to document their self-management activities daily for 1 week before a scheduled interview. Data were analyzed using thematic analysis. The results showed (1) fifteen participants completed the diary and n = 9 completed all 7 days with detailed information regarding self-management. (2) A majority of the participants ( n = 13) found the diary easy to use. A few participants ( n = 3) shared individual-level challenges including preferring to document over several months, difficulty finding time to document, and difficulty putting thoughts into words. Suggestions to promote diary completion in future research included allowing participants to either document for only 1 day or allowing them to provide a summary of their weekly routine activities, sending reminders, and having more specific prompts. (3) For participants who completed the diary, we were able to customize the interview questions, which enhanced the richness of the interview data and captured greater complexity of self-management activities over time. Using diaries can promote the customization of interview questions and facilitate capturing rich interview data.
An emergency urology skills course for the multidisciplinary team
Authors: Gallagher Jessica , Crockett Matthew , McMeekin Faith 
Published: August 2021

Urological presentations account for approximately 1.7% of emergency hospital admissions, 7.8–20% of the acute surgical take and 5–10% of visits to general practice. Training in this area is often unsatisfactory, with a third of final year medical students not feeling confident in managing urological emergencies and 6% receiving no exposure at all. Urology is a multidisciplinary speciality, and many emergency urological presentations require urgent treatment with specialised equipment or skills. A quality improvement project was set up at Gloucestershire Hospitals NHS Foundation Trust with the aim of improving experience and confidence among junior doctors and allied health-care professionals with common urological practical skills using a simulation-based course. There was an emphasis on multidisciplinary team working to mirror the clinical environment. Pre-course questionnaires showed that most participants lacked confidence with common urology practical skills, such as haematuria management (80–85%), nephrostomy management (93–95%) and suprapubic catheters (93–100%). After attending the course, confidence improved in all skills, and participant satisfaction was high, with 100% finding the course relevant to clinical practice. The course was run at low cost, free to participants and without the need for long periods of study leave, making it accessible to all. We suggest the model of this course could be easily transferred to other hospital trusts and applied to other surgical specialities for similar simulated training. Level of evidence: Level 5.
Scrotal bridge flap reconstructive surgery for extensive penile paraffinoma: steps and outcomes from a single center: a case series
Authors: Khairudin Muhammad Arif , Salauddin Syahril Anuar , Ghazali Hamid 
Published: August 2021

Abstract
Background
To describe our scrotal bridge flap technique in reconstructive surgery for extensive penile paraffinoma, a debilitating late complication of penile subcutaneous foreign material injection intended to achieve penile augmentation.

Case presentation
We reviewed the medical records of 10 patients who underwent reconstructive surgery with the scrotal bridge flap technique for penile paraffinoma at our center between 2016 and 2019. Complete excision of fibrotic tissue and the overlying skin was performed, and penile resurfacing was achieved by mobilizing the scrotal skin superiorly to wrap around the penile shaft, leaving a skin bridge at the median raphe. All 10 patients successfully underwent scrotal bridge flap penile reconstruction with satisfying results. The mean operation duration was 286.1 min (range 213–363 min). No immediate major complications were observed in any of the patients, and no patients required revision surgery.

Conclusion
The scrotal bridge flap technique is a reliable method for reconstructive surgery after the excision of penile paraffinoma.
Sociodemographic characteristics and transmission risk factors in patients hospitalized for COVID-19 before and during the lockdown in France
Authors: Rahi Mayda , Le Pluart Diane , Beaudet Alexandra , Ismaël Sophie , Parisey Marion , Poey Nora , Tarhini Hassan , Lescure François-Xavier , Yazdanpanah Yazdan , Deconinck Laurène 
Published: August 2021

AbstractBackgroundThe efficacy of lockdown in containing the COVID-19 pandemic has been reported in different studies. However, the impact on sociodemographic characteristics of individuals infected with SARS-CoV-2 has not been evaluated. The aim of this study was to describe the changes in sociodemographic characteristics of patients hospitalized for COVID-19 and to compare the transmission risk factors of COVID-19 before and during lockdown in France.MethodsAn observational retrospective study was conducted in a University Hospital in Paris, France. Data from patients hospitalized for COVID-19 in the Infectious Diseases Department between February 26 and May 11, 2020 were collected. The study population was divided into 2 groups: group A of patients infected before lockdown, and group B of patients infected during lockdown, considering a maximum incubation period of 14 days. Sociodemographic characteristics and transmission risk factors were compared between the 2 groups using Student’s t-test for continuous variables and Chi-2 test or Fisher exact test for categorical variables.ResultsThree hundred eighty-three patients were included in the study, 305 (79.6%) in group A and 78 (20.4%) in group B. Patients in group A were significantly younger (60.0 versus (vs) 66.5 years (p = 0.03)). The professionally active population was larger in group A (44.3% vs 24.4%). There were significantly more non-French-speaking people in group B (16.7% vs 6.6%,p <  0.01). Most patients from group A had individual accommodation (92.8% vs 74.4%, p <  0.01). Contact with a relative was the main transmission risk factor in both groups (24.6% vs 33.3%,p = 0.16). Recent travel and large gathering were found only in group A. The proportion of people living in disadvantaged conditions, such as homeless people or people living in social housing, was significantly higher in group B (11.5% vs 4.3%,p = 0.03) as was the proportion of institutionalized individuals (14.1% vs 3.0%,p <  0.01).ConclusionsIn this study conducted in patients hospitalized for COVID-19 in Paris, France, the likelihood of being infected despite the lockdown was higher for people who do not speak French, live in social housing, are homeless or institutionalized. Targeted measures have to be implemented to protect these populations.
Efficiency of a deep learning-based artificial intelligence diagnostic system in spontaneous intracerebral hemorrhage volume measurement
Authors: Wang Tao , Song Na , Liu Lingling , Zhu Zichao , Chen Bing , Yang Wenjun , Chen Zhiqiang 
Published: August 2021

Abstract
Background
Accurate measurement of hemorrhage volume is critical for both the prediction of prognosis and the selection of appropriate clinical treatment after spontaneous intracerebral hemorrhage (ICH). This study aimed to evaluate the performance and accuracy of a deep learning-based automated segmentation algorithm in segmenting spontaneous intracerebral hemorrhage (ICH) volume either with or without intraventricular hemorrhage (IVH) extension. We compared this automated pipeline with two manual segmentation techniques.

Methods
We retrospectively reviewed 105 patients with acute spontaneous ICH. Depending on the presence of IVH extension, patients were divided into two groups: ICH without (n = 56) and with IVH (n = 49). ICH volume of the two groups were segmented and measured using a deep learning-based artificial intelligence (AI) diagnostic system and computed tomography-based planimetry (CTP), and the ABC/2 score were used to measure hemorrhage volume in the ICH without IVH group. Correlations and agreement analyses were used to analyze the differences in volume and length of processing time among the three segmentation approaches.

Results
In the ICH without IVH group, the ICH volumes measured using AI and the ABC/2 score were comparable to CTP segmentation. Strong correlations were observed among the three segmentation methods (r = 0.994, 0.976, 0.974; P < 0.001; concordance correlation coefficient [CCC] = 0.993, 0.968, 0.967). But the absolute error of the ICH volume measured by the ABC/2 score was greater than that of the algorithm (P < 0.05). In the ICH with IVH group, there is no significant differences were found between algorithm and CTP(P = 0.614). The correlation and agreement between CTP and AI were strong (r = 0.996, P < 0.001; CCC = 0.996). The AI segmentation took a significantly shorter amount of time than CTP (P < 0.001), but was slightly longer than ABC/2 score technique (P = 0.002).

Conclusions
The deep learning-based AI diagnostic system accurately quantified volumes of acute spontaneous ICH with high fidelity and greater efficiency compared to the CTP measurement and more accurately than the ABC/2 scores. We believe this is a promising tool to help physicians achieve precise ICH quantification in practice.