bluuebunny/crossref_metadata_2025_split huggingface dataset:
PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese
Authors: Cardoso Glêbia A. , Ribeiro Mateus D. , Sousa Bruno R. V. , de Oliveira Yohanna , Sena Klécia F. , Batista Joane R. E. , Almeida Antônio E. M. , Filho João M. , Silva Raquel S. B. , Persuhn Darlene C. , Silva Alexandre S. 
Published: August 2021

The objective of this study was to investigate the relationship of the polymorphism in Intron 7 G/C (rs 4253778) of the peroxisome proliferator-activated receptor alpha (PPARα) gene with the magnitude of changes in the body composition of an overweight and obese population that underwent an aerobic training program. Fifty-eight previously inactive men and women, body mass index (BMI)

31.5
±
2.8

kg
/

m

2

, 46.5% (

n
=
27

) genotyped as CC genotype and 53.5% (

n
=
31

) as CA+AA, underwent a 12-week aerobic training (walking/running). Aerobic capacity (ergospirometry), body composition (DXA), and nutritional assessment were made before and 48 h after the experimental protocol. Two-way ANOVA, chi-square test, and logistic regression were used (

p
<
0.05

). Twenty-seven volunteers (46.5%) were identified as CC genotype and 31 (53.5%) as CA+AA genotype. Time-group interaction showed that there was no difference in these between two allele groups. However, differences in distribution of respondents or nonresponders according to allele A were identified for fat mass (

p
≤
0.003

), percentage fat mass (

p
≤
0.002

), the waist (

p
≤
0.009

), abdomen (

p
≤
0.000

), and hip (

p
≤
0.001

), this difference being independent for the fat mass. Meanwhile, sex, age, and nutritional management have also been found to be influential factors. It is concluded that the PPARα gene is involved in varying body composition in response to an aerobic training program.
Plasma Metabolic Phenotypes of HPV-Associated versus Smoking-Associated Head and Neck Cancer and Patient Survival
Authors: Eldridge Ronald C. , Uppal Karan , Hayes D. Neil , Smith M. Ryan , Hu Xin , Qin Zhaohui S. , Beitler Jonathan J. , Miller Andrew H. , Wommack Evanthia C. , Higgins Kristin A. , Shin Dong M. , Ulrich Bryan , Qian David C. , Saba Nabil F. , Bruner Deborah W. , Jones Dean P. , Xiao Canhua 
Published: August 2021

Abstract

Background:
Metabolic differences between human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) and smoking-associated HNSCC may partially explain differences in prognosis. The former relies on mitochondrial oxidative phosphorylation (OXPHOS) while the latter relies on glycolysis. These differences have not been studied in blood.

Methods:
We extracted metabolites using untargeted liquid chromatography high-resolution mass spectrometry from pretreatment plasma in a cohort of 55 HPV-associated and 82 smoking-associated HNSCC subjects. Metabolic pathway enrichment analysis of differentially expressed metabolites produced pathway-based signatures. Significant pathways (P &lt; 0.05) were reduced via principal component analysis and assessed with overall survival via Cox models. We classified each subject as glycolytic or OXPHOS phenotype and assessed it with survival.

Results:
Of 2,410 analyzed metabolites, 191 were differentially expressed. Relative to smoking-associated HNSCC, bile acid biosynthesis (P &lt; 0.0001) and octadecatrienoic acid beta-oxidation (P = 0.01), were upregulated in HPV-associated HNSCC, while galactose metabolism (P = 0.001) and vitamin B6 metabolism (P = 0.01) were downregulated; the first two suggest an OXPHOS phenotype while the latter two suggest glycolytic. First principal components of bile acid biosynthesis [HR = 0.52 per SD; 95% confidence interval (CI), 0.38–0.72; P &lt; 0.001] and octadecatrienoic acid beta-oxidation (HR = 0.54 per SD; 95% CI, 0.38–0.78; P &lt; 0.001) were significantly associated with overall survival independent of HPV and smoking. The glycolytic versus OXPHOS phenotype was also independently associated with survival (HR = 3.17; 95% CI, 1.07–9.35; P = 0.04).

Conclusions:
Plasma metabolites related to glycolysis and mitochondrial OXPHOS may be biomarkers of HNSCC patient prognosis independent of HPV or smoking. Future investigations should determine whether they predict treatment efficacy.

Impact:
Blood metabolomics may be a useful marker to aid HNSCC patient prognosis.
EFL university teachers’ perspectives in written corrective feedback and their actual applications
Authors: Purnomo Windy Wahju , Basthomi Yazid , Prayogo Johannes Ananto 
Published: August 2021

<p>This study aimed to investigate the English as a foreign language (EFL) university teachers’ perspective and their actual applications in providing written corrective feedback to the writing errors made by the EFL university students and their correlation. The study was based on 80 responses of a Google-Form survey distributed to EFL university teachers with various teaching experiences from the most parts of Indonesia. Correlational design was used in this research. Descriptive statistics and Pearson’s correlation tests were used to analyze data. The results indicated that the majority of teachers had perspectives that it is valuable to provide and vary the strategies of written corrective feedback. In addition, the teachers mostly applied both direct and indirect feedback in various strategies and they only sometimes provided corrections in all aspects of errors and reformulation. It was also found out that the Indonesian EFL university teachers’ perspectives in the written corrective on students’ writing errors highly correlated with their actual applications. The results of the study provide both theoretical and pedagogical implications. Theoretically, it enriches the body knowledge of feedback and EFL writing. Pedagogically, EFL teachers are also suggested to improve their knowledge on various feedback techniques and apply it in their classroom teaching and learning process.</p><p> </p>
Comparative Outcomes of Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Among Medicare Beneficiaries With Multivessel Coronary Artery Disease: An National Cardiovascular Data Registry Research to Practice Project
Authors: Secemsky Eric A. , Butala Neel , Raja Aishwarya , Khera Rohan , Wang Yongfei , Curtis Jeptha P. , Maddox Thomas M. , Virani Salim S. , Armstrong Ehrin J. , Shunk Kendrick A. , Brindis Ralph G. , Bhatt Deepak , Yeh Robert W. 
Published: August 2021

Background:
Prior studies on the use of multivessel percutaneous coronary intervention (MV PCI) for patients with ST-segment–elevation myocardial infarction (STEMI) and multivessel coronary artery disease have yielded heterogeneous results. The recent COMPLETE trial (Complete Versus Culprit-Only Revascularization Strategies to Treat Multivessel Disease After Early PCI for STEMI) demonstrated that MV PCI was superior to culprit-only PCI among patients with STEMI. It is unclear how these trial results apply to clinical decisions encountered in routine practice.

Methods:
We studied STEMI admissions among patients >65 years with multivessel disease and Centers for Medicare and Medicaid Services–linked data in the National Cardiovascular Data Registry CathPCI Registry from July 1, 2009 to December 31, 2017. MV PCI was defined as PCI to a nonculprit lesion ≤45 days of the index procedure. The primary outcome was the composite of death, myocardial infarction, and revascularization from 45 days through 1 year. To account for unmeasured confounders, an instrumental variable analysis was used to compare treatment strategies. The instrument was institutional rates of MV PCI. A falsification end point of postdischarge major bleeding was utilized to assess for residual confounding.

Results:

Of 56 332 admissions from 1102 institutions, 37.7% received MV PCI ≤45 days of index STEMI PCI. Of those undergoing MV PCI, 74.8% received complete revascularization. In unadjusted analysis, MV PCI was associated with a lower cumulative incidence of the composite outcome between 45 days and 1 year (13.9% versus 18.2% for non-MV PCI,
P
<0.01). In the instrumental variable analysis, there was no association between MV PCI and the composite outcome (adjusted risk difference, −0.97% [95% CI, −3.52% to 1.59%];
P
=0.46). An association between MV PCI and the falsification end point of major bleeding was not observed (adjusted risk difference, −2.54% [95% CI, −5.30% to 0.22%];
P
=0.07).

Conclusions:
In this large, nationwide analysis, we did not find benefit of MV PCI by 1 year among older STEMI patients. The clinical benefit of MV PCI may not extend equally outside of trials to include all patients, including those with more extreme ages and more complex decision-making.
Google Plus as a Contentious Field of Revolutionary Identity
Authors: Teimouri Amirhossein 
Published: August 2021

Abstract
Social media platforms have been increasingly reinvigorating extreme movements, especially rightist movements. Utilizing unique Google Plus data, the author shows the rise and fall of the 2015 rightist anti-Nuclear Deal movement in Iran. He argues that the Google Plus platform in 2015 provided the new generation of revolutionary Islamist rightist activists with a contentious space of mobilization, enabling them to develop a new revolutionary rightist identity. This revolutionary identity and its corresponding language and discourse did not fully unfold in Iranian mainstream rightist media, even though rightist groups, compared to liberal groups, are not censored and repressed. The new generation of rightist activists perceived the Nuclear Deal as an existential threat to revolutionary principles of the country, and thus played out their outrage and identity anxieties on Google Plus. The author contends that this online outrage, due to the activists’ identity bond with the regime and the 1979 Iranian Revolution, however, did not translate into any massive offline mobilization against the Nuclear Deal. He also discusses the methodological implications of using social media data, especially the discontinuation of Google Plus.
The Online Intersection among Islamophobia, Populism, and Hate Speech: An Italian Perspective
Authors: Vitullo Alessandra 
Published: August 2021

Abstract
Online radical Islam is a topic widely studied by scholars and notoriously discussed among non- experts as well (Awan, 2007; Von Behr et al. 2013; Gray & Head 2009). Because of its intrinsic characteristics (i.e. accessibility, anonymity, or users’ identity dissimulation), the internet has always been a useful tool for propagandists of Islamic fundamentalism (Fighel, 2007; Stenersen, 2008; Koehler, 2014). However, in the last decade, studies have questioned the real importance and magnitude of Islamic radicalization online (Gill et al., 2017). In fact, while scholars were focused on observing digital Islamic radicalization, a galaxy of new forms of extremism was growing online (Silva et al., 2017; Roversi, 2008) that no longer made Islam an exceptional case study. Today, Muslim people are one of the groups most aggressively targeted by extremist, intolerant, violent, and radical discourses (Elahi & Khan, 2017; Amnesty International, 2019). Anti-Muslim hate speech has spread online throughout Europe and the United States, reinforced by the propaganda and political discourse of populist right-wing parties (Hafez, 2014; Bakali 2016). This paper introduces some large-scale action-research projects developed in Europe and Italy in the last three years (2016–2019) and aims to reconstruct the most updated Islamophobia state of the art in terms of numbers, characteristics, and phenomenology from the offline to the online context.
The role of brush encroachment in Mediterranean ecosystems: a review
Authors: Henkin Zalmen 
Published: August 2021

Abstract
Encroachment of woody plants into grasslands and subsequent brush management are among the most prominent changes occurring in arid and semiarid ecosystems over the past century. The reduced number of farms, the abandonment of marginal land and the decline of traditional farming practices have led to encroachment of the woody and shrubby components into grasslands. This phenomenon, specifically in the Mediterranean region, which is followed by a reduction in herbage production, biodiversity and increased fire risk, is generally considered an undesirable process. Sarcopoterium spinosum has had great success in the eastern Mediterranean as a colonizer and dominant bush species on a wide variety of sites and climatic conditions. In the Mediterranean dehesa, the high magnitude and intensity of shrub encroachment effects on pastures and on tree production were shown to be dependent on temporal variation. Accordingly, there are attempts to transform shrublands into grassland-woodland matrices by using different techniques. The main management interventions that are commonly used include grazing, woodcutting, shrub control with herbicides or by mechanical means, amelioration of plant mineral deficits in the soil, and fire. However, the effects of these various treatments on the shrubs under diverse environmental conditions were found to be largely context-specific. As such, the most efficient option for suppressing encroachment of shrubs is combining different interventions. Appropriate management of grazing, periodic control of the shrub component, and occasional soil nutrient amelioration can lead to the development of attractive open woodland with a productive herbaceous understory that provides a wider range of ecological services.
A single-center experience with giant cell tumors of sphenoid bone and clivus
Authors: Yaprak Bayrak Büşra , Özcan Emre , Vural Çiğdem , Emengen Atakan , Çabuk Burak , Ceylan Savaş 
Published: August 2021

Objective: To present pathologic, clinical, and treatment findings for giant cell tumors (GCTs) of sphenoid bone and clivus. Methods: We describe the optimal treatment algorithm in patients with a histopathologic diagnosis of bone GCT by presenting the effects of denosumab treatment in both pediatric and adult patients with GCT undergoing endoscopic transnasal surgery. Clinicopathologic correlation is crucial for the differential diagnosis of GCT and the choice of treatment modality. Conclusion: GCT of bone is a local aggressive tumor that accounts for about 3%–7% of all bone tumors. GCTs located in the cranium are extremely uncommon neoplasms. There are no defined guidelines for the treatment of GCTs in skull base. Following surgical resection of the tumor, the addition of denosumab treatments to radiotherapy has a significant role in preventing the recurrence of GCT and in promoting regression of residual tumor size.
Measuring Early Childhood Mathematical Cognition: Validating and Equating Two Forms of the Research-Based Early Mathematics Assessment
Authors: Dong Yixiao , Clements Douglas H. , Day-Hess Crystal A. , Sarama Julie , Dumas Denis 
Published: August 2021

Psychometric work with young children faces the particular challenge that children’s attention spans are relatively short, and therefore, shorter assessments are required while retaining comprehensive coverage. This article reports on three empirical studies that encompass the development and validation of the research-based early mathematics assessment-short form (REMA-SF), an instrument that measures the early mathematical competency of children from 3 to 8 years of age. The developed measure captures both children’s mathematical performance and the strategies children use to solve math problems. Results indicated that the REMA-SF can produce valid scores for measuring children’s math skills in early childhood, and the validity of the measure can be well-generalized to an external (or independent) sample. Additionally, we also equated the REMA scores between the long and short forms of the assessment: anchor items common across the forms were selected and refined in the equating process.
The Effects of Exposure to Domestic Violence on Sleep Among Urban Adults
Authors: Schober Daniel J. , Shrestha Susana , Bishop-Royse Jessica C. 
Published: August 2021

Purpose: Domestic violence contributes to poor health including sleep disruptions, which has been associated with risk for chronic conditions and ultimately, premature mortality. The present study examined the effects of ever witnessing domestic violence on sleep among urban neighborhoods of color. Design: Cross-sectional. Setting: Ten of Chicago’s 77 community areas. Participants: Adults, aged 18 years and older (N = 1,543, Response Rate = 28.4%). Over 49% of participants reported a Hispanic ethnicity, 34.8 percent reported being non-Hispanic Black and 14.2 percent reported being White. Measures: We used the Sinai Community Health Survey, 2.0, to examine: average hours of sleep in a 24-hour period, ever witnessing domestic violence, ever being emotionally or physically abused, frequent stress in the past 12 months, and other key covariates (race and ethnicity, annual household income, sex, and health status). Analysis: Multivariate logistic regression. Results: In the full model, participants who reported witnessing domestic violence were significantly less likely to report meeting sleep recommendations even after controlling for ever being emotionally or physically abused, frequently feeling stress, demographic factors, and health status. Non-Hispanic Blacks were most likely to report not meeting sleep recommendations (OR = .54, 95% CI = .30-.96, P = .036). Conclusion: Witnessing domestic violence contributes to not meeting sleep recommendations and this appears to be most salient for Non-Hispanic Blacks. These point-in-time findings document an important potential contributor to racial health disparities.
Baby Friendly Hospital Initiative Breastfeeding Outcomes in Mothers with COVID-19 Infection During the First Weeks of the Pandemic in Spain
Authors:   Neo-COVID-19 Research Group:, Marín Gabriel Miguel A , Domingo Comeche Laura , Cuadrado Pérez Irene , Reyne Vergeli Mar , Forti Buratti Azul , Royuela Vicente Ana , Olabarrieta Arnal Iciar , Sánchez Laura , Alonso Díaz Clara , Criado Enrique , Carrizosa Molina Tamara , Caserío Carbonero Sonia , Casas Satre Cristina , Fernández-Cañadas Morillo Aurora , de Alba Concepción , de las Heras Susana , Martínez Lucía , Villar Gema , Solé Laia , Llana Isabel , Palanca Inmaculada , Álvarez Blanca , Dacosta Ana Isabel , Rivero Irene , Río Ruth del , González Ersilia , Dip María Emilia , Olza Ibone 
Published: August 2021

Background: Adherence to the Ten Steps of the Baby-Friendly Hospital Initiative has been shown to have a protective role for the initiation and maintenance of breastfeeding. Research Aims: (1) To determine the breastfeeding rate during the first 6 months of life in children of mothers diagnosed with COVID-19 infection at the time of birth; and (2) to assess the possible influence of being born in a center with Baby-Friendly Hospital Initiative accreditation. Methods: This was a two-group comparative longitudinal observational study of infants born to mothers with COVID-19 at the time of birth, between March 13–May 31, 2020 (the first wave of the pandemic) in Spain. Fourteen Spanish hospitals participated, five (35.7%) were Baby-Friendly Hospital Initiative accredited. Type of feeding was assessed prospectively at discharge, 1, 3, and 6 months of age. A total of 248 newborns were included in the study. Results: A total of 117 (47.3%) newborns were born in Baby-Friendly Hospital Initiative (BFHI) accredited centers. These centers applied skin-to-skin contact with greater probability ( OR = 1.9; 95% CI [1.18, 3.29]) and separated the newborns from their mothers less frequently ( OR = 0.46; 95% CI [0.26, 0.81]) than non-accredited centers. No differences were observed in relation to the presence of a companion at the time of birth. At discharge, 49.1% ( n = 57) of newborns born in BFHI-accredited centers received exclusive breastfeeding versus 35.3% ( n = 46) in non-accredited centers ( p = .03). No differences were observed in breastfeeding rates throughout follow-up. Conclusions: The exclusive breastfeeding rate at discharge in children of mothers with COVID-19 infection at birth was higher in Baby-Friendly Hospital Initiative accredited centers, which most frequently applied skin-to-skin contact at birth as well as rooming-in.
Design and simulation analysis of impact-resistant flexible drill pipe for rock-breaking rig
Authors: Gao Kangping , Xu Xinxin , Shi Ning , Jiao Shengjie 
Published: August 2021

In the process of drilling and coring by the rock-breaking rig, the drill rod is affected by the intermittent impact force, which reduces the efficiency of the rig to break the rock and increases the cost of the drilling and coring. Therefore, it is very important to improve the impact resistance of the drill pipe during the rock-breaking process. To achieve this goal, a flexible design of the drill pipe was carried out, and a dynamical model of the drilling rig based on a series elastic actuator was established. Considering the dynamic performance of the system, a torque feedforward link is introduced and a control model based on the force source is established. The influence of the equivalent inertia of the transmission system and the series elastic actuator damping coefficient on the system stability was analyzed by drawing the frequency domain characteristic curve of the system. By using the control and Simulink simulation software, the electromechanical simulation of the model is carried out, and the torque step tracking response of the system is obtained. A torque feedforward link is introduced to establish the control model of the system based on force source. Through dynamic simulation software ADAMS, dynamic and static impact simulation experiments were carried out on the system. The results show that when a force of 200 N is applied to the output end of the drill pipe in the tangential direction, the maximum moments received by the joint under static and dynamic environments are 34.1 N·m and 57.9 N·m, respectively. When the impact force disappears, the time required for the flexible drill pipe to reach a stable state is only 0.15 s, which verifies that the series elastic actuator–based drill pipe model can alleviate the impact of the external environment and protect the internal structure of the rig.
Long non-coding RNA Down syndrome cell adhesion molecule-anti-sense 1 promotes gastric carcinoma cell proliferation and migration by regulating the miR-204/TPT1 axis
Authors: Wang Nan , Yang Ying , Jia Guo-Zhan , Wang Ke , Zhou Shuai , Zhang Bo , Zhang Zhan-Sheng , Qiao Qing , He Xian-Li 
Published: August 2021

Background: Several recent studies have suggested that the long non-coding RNA (lncRNA) DSCAM-AS1 (Down syndrome cell adhesion molecule - anti-sense 1) is aberrantly expressed in many malignancies. Purpose: In this study, we aimed to explore the the role of DSCAM-AS1 in gastric carcinoma. Research Design: Expression of DSCAM-AS1 mRNA, miR-204, and TPT1 (Tumor Protein, Translationally-Controlled 1) were detected using quantitative real-time polymerase chain reaction (qRT-PCR). Proliferation and apoptosis of GC cells were determined using the CCK-8 cell counting assay and flow cytometry. The rate of cell migration and invasion was determined using a transwell assay. The relationships between DSCAM-AS1, miR-204, and TPT1 were predicted and confirmed using a dual-luciferase reporter assay. Expression of TPT1 protein was quantified by Western blot. Results: In this study, we found that DSCAM-AS1 was significantly overexpressed in GC tissues and cell lines. Functional experiments indicated that GC cells with DSCAM-AS1 silencing exhibited a dynamic reduction in proliferation and migration. We identified miR-204 as a target of DSCAM-AS1 and found that it targeted TPT1 in GC cells, which further led to decreased expression of miR-204 in GC tissues and cell lines. A rescue assay revealed that knocked-down DSCAM-AS1 hindered GC progression, which was reversed upon miR-204 downregulation or TPT1 overexpression. Conclusion: We conclude that DSCAM-AS1 is expressed as a tumor oncogene in GC progression, modulated via the miR-204/TPT1 axis. These findings indicate the potential of DSCAM-AS1 as a therapeutic target for GC prevention.