bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synopsis of a clinical practice guideline for pancreatic ductal adenocarcinoma with peritoneal dissemination in Japan; Japan Peritoneal Malignancy Study Group
Authors: Satoi Sohei , Takahara Naminatsu , Fujii Tsutomu , Isayama Hiroyuki , Yamada Suguru , Tsuji Yasushi , Miyato Hideyo , Yamaguchi Hironori , Yamamoto Tomohisa , Hashimoto Daisuke , Yamaki So , Nakai Yousuke , Saito Kei , Baba Hayato , Watanabe Toru , Ishii Shigeto , Hayashi Masamichi , Kurimoto Keisuke , Shimada Hideaki , Kitayama Joji 
Published: December 2021

AbstractPatients with pancreatic ductal adenocarcinoma (PDAC) with peritoneal dissemination have a dismal prognosis because discontinuation of systemic chemotherapy is required for massive ascites or poor performance status. The natural history, diagnosis and treatment of PDAC with peritoneal dissemination have not been fully investigated. We systematically reviewed published information on the clinical diagnosis and treatment of PDAC with peritoneal dissemination using the PubMed database (2000‐2020) and provided recommendations in response to clinical questions. This guideline was created according to the "Minds Clinical Practice Guideline Development Guide 2017". The literature quality and body of evidence were evaluated with the GRADE System and classified into four levels (“strong”, “medium”, “weak”, “very weak”). The strength of each final recommendation was decided by a vote of committee members based on the GRADE Grid method. These guidelines address three subjects: diagnostic, chemotherapeutic, and surgical approaches. They include nine clinical questions and statements with recommendation strengths, evidence levels, and agreement rates, in addition to one “column”. This is the English synopsis of the 2021 Japanese clinical practice guideline for PDAC with peritoneal dissemination. It summarizes the clinical evidence for the diagnosis and treatment of PDAC with peritoneal dissemination and provides future perspectives.
Prevalence characteristics of cervical human papillomavirus genotypes in Nanning, China: A 10‐year survey of 77,756 women from one medical center
Authors: Wei Xiaoning , Lu Qinghua , Wang Shaowei 
Published: December 2021

AbstractObjectivesThe prevalence of human papillomavirus (HPV) infection and HPV genotypes varies in different regions. However, there is little data on HPV prevalence and genotyping in Guangxi Province, South China. This study conducted a 10‐year survey in a health center, to estimate the prevalence characteristics of HPV genotypes.MethodsBy using polymerase chain reaction (PCR) amplification and nucleic acid molecular hybridization, the HPV genotypes were detected from 77,756 females who were patients of the Department of Obstetrics and Gynecology and those who visited the Health Management Center for a physical examination between August 2011 and November 2020. The prevalence, genotypes, age‐related HPV infections, as well as chronological change of HPV prevalence, and the HPV genotype distribution were analyzed.ResultsThe overall prevalence of HPV infection was 21.14% (16,439/77,756). The HPV infection rate differed significantly between the patients of the Department of Obstetrics and Gynecology and the women who underwent a physical examination (22.98% vs. 9.88%, p < 0.05). The prevalence rates of high‐risk HPV, low‐risk HPV, mixed HPV (mixed high‐risk, and low‐risk HPV infection), and multiple HPV infections were 18.96% (14,739/77,756), 4.09% (3178/77,756), 1.90% (1478/77,756), and 4.94% (3838/77,756), respectively. The most prevalent genotypes were HPV 52, 16, and 58. The age‐associated HPV prevalence showed bimodal curves, with the first peak at <25 years and the second peak at >56 years.ConclusionsThis study provides baseline data on the HPV prevalence in the general female population of Nanning, Guangxi Province. Women <25 and >56 years old faced the greatest threat of HPV infection, and HPV 52, 16, and 58 were the most common genotypes.
High‐dose supplementation of selenium in left ventricular assist device implant surgery: A double‐blinded, randomized controlled pilot trial
Authors: Laaf Elena , Benstoem Carina , Rossaint Rolf , Wendt Sebastian , Fitzner Christina , Moza Ajay , Zayat Rashad , Hill Aileen , Heyland Daren K. , Schomburg Lutz , Goetzenich Andreas , Stoppe Christian 
Published: December 2021

AbstractBackgroundSystemic inflammation and oxidative stress remain the main causes of complications in patients with heart failure receiving a left ventricular assist device (LVAD). Selenoproteins are a cornerstone of antioxidant defense mechanisms for improving inflammatory conditions.MethodsIn a monocentric, double‐blinded pilot trial patients scheduled for LVAD implantation were randomized to receive 300 mcg of selenium orally the evening before surgery, followed by a high‐dose of intravenous selenium supplementation (3000 mcg after anesthesia induction, 1000 mcg upon intensive care unit [ICU] admission, and 1000 mcg daily in the ICU for a maximum of 14 days) or placebo. The main outcomes were feasibility and effectiveness in restoring serum selenium concentrations.ResultsTwenty patients were included in the analysis. The average duration of study intervention was 12.6 days (7–14), with 97.7% dose compliance. No patient received open‐label selenium. The supplementation strategy was effective in compensating low serum selenium concentrations (before surgery: control, 63.5 ± 11.9 mcg/L vs intervention, 65.8 ± 16.5 mcg/L; ICU admission: control, 49.0 ± 9.8 mcg/L vs intervention, 144.2 ± 45.4 mcg/L). Serum selenium concentrations in the intervention group were significantly higher during the observation period (baseline: mean of placebo (MoP), 63.1 vs mean of selenium (MoS), 64.0; ICU admission: MoP, 49.0 vs MoS, 144.6; day 1‐13: MoP, 43.6‐48.5 vs MoS, 100.4‐131.0).ConclusionSelenium supplementation in patients receiving LVAD implantation is feasible and effective to compensate a selenium deficiency.
Natural Course of Fetal Hyaloid Artery: SlowflowHD Longitudinal Study
Authors: Hata Toshiyuki , Koyanagi Aya , Yamanishi Tomomi , Bouno Saori , Takayoshi Riko , Miyake Takahito 
Published: December 2021

ObjectiveTo assess the natural course of the fetal hyaloid artery (FHA) using SlowflowHD during pregnancy.MethodsOne‐hundred and eighteen normal fetuses were studied longitudinally using SlowflowHD to assess the natural course of FHA at 18–21 + 6, 28–31 + 6, and after 35 weeks of gestation. Blood flow of FHA with/without its branches (BF) was evaluated using SlowflowHD, and the band of FHA without blood flow (Band) was identified in each gestational period. The natural course of FHA was classified into six types: Type A, not detected (ND) in each gestational period; Type B, Band at 18–21 + 6 weeks; Type C, Band at 18–21 + 6 and 28–31 + 6 weeks; Type D, BF at 18–21 + 6 weeks; Type E, BF at 18–21 + 6 weeks and Band at 28–31 + 6 weeks; Type F, BF at 18–21 + 6 and 28–31 + 6 weeks.ResultsBF, Band, and ND were 83.5, 15.5, and 1.0% at 18–21 + 6 weeks, 8.8, 15.5, and 75.7% at 28–31 + 6 weeks, and 0, 0, and 100% after 35 weeks, respectively. Type A was 1.0%, Type B was 13.6%, Type C was 1.9%, Type D was 61.2%, Type E was 13.6%, and Type F was 8.7%.ConclusionsThe presence of FHA blood flow before 30 weeks of gestation should be regarded as a physiologic phenomenon in normal fetuses.
Polymer Architecture Effects on Poly(N,N‐Diethyl Acrylamide)‐b‐Poly(Ethylene Glycol)‐b‐Poly(N,N‐Diethyl Acrylamide) Thermoreversible Gels and Their Evaluation as a Healthcare Material
Authors: Haddow Peter J. , da Silva Marcelo A. , Kaldybekov Daulet B. , Dreiss Cecile A. , Hoffman Ewelina , Hutter Victoria , Khutoryanskiy Vitaliy V. , Kirton Stewart B. , Mahmoudi Najet , McAuley William J. , Cook Michael T. 
Published: December 2021

AbstractThermoreversible gels which transition between liquid‐like and solid‐like states when warmed have enabled significant novel healthcare technologies. Poly(N,N‐diethyl acrylamide) (PDEA) is a thermoresponsive polymer which can be used as a trigger to form thermoreversible gels, however its use in these materials is limited and crucial design principles are unknown. Herein ABA copolymers with the structure PDEA‐b‐poly(ethylene glycol) (PEG)‐b‐PDEA are synthesized to give four block copolymers with varied molecular weight of PDEA and PEG blocks. Rheometry on solutions of the block copolymers reveals that high molecular weight PEG blocks are required to form thermoreversible gels with predominantly solid‐like behavior. Furthermore, small‐angle X‐ray scattering elucidates clear differences in the nanostructure of the copolymer library which can be linked to distinct rheological behaviors. A thermoreversible gel formulation based on PDEA (20 kDa)‐b‐PEG (10 kDa)‐b‐PDEA (20 kDa) is designed by optimizing the polymer concentration and ionic strength. It is found that the gel is mucoadhesive, stable, and non‐toxic, as well as giving controlled release of a hydrophobic drug. Overall, this study provides insight into the effect of polymer architecture on the nanostructure and rheology of PDEA‐b‐PEG‐b‐PDEA and presents the development of a highly functional thermoreversible gel with high promise for healthcare applications.
Clinical, pathologic, and molecular features of inflammatory myofibroblastic tumors in children and adolescents
Authors: Pire Aurore , Orbach Daniel , Galmiche Louise , Berrebi Dominique , Irtan Sabine , Boudjemaa Sabah , Brisse Hervé J. , Berteloot Laureline , Moalla Salma , Mussini Charlotte , Philippe‐Chomette Pascale , Tilea Bogdana , Pierron Gaelle , Guerin Florent , Minard‐Colin Véronique , Sarnacki Sabine 
Published: December 2021

AbstractBackgroundInflammatory myofibroblastic tumors (IMT) are rare, intermediate malignant tumors harboring frequent somatic molecular rearrangements. The management of IMT has not been standardized.MethodsA retrospective multicenter study was conducted on all pediatric patients treated for IMT between 2000 and 2019.ResultsThis series included 39 cases of IMT, with a median age at diagnosis of 7 years (range 20 days to 16 years). Tumor location included pelvis‐abdomen (n = 16), thorax (n = 14), head and neck (n = 7), and limbs (n = 2). One patient had metastatic disease. Immunochemistry showed 21/39 (54%) anaplastic lymphoma kinase (ALK)‐positive tumors. Somatic tyrosine kinase rearrangement was present in 31/36 (86%) of the tumors analyzed: 21 ALK, five ROS1, and five NTRK. Immediate surgery was performed in 24 patients (62%), with adjuvant therapy for three patients. Delayed surgery after neoadjuvant therapy was possible in 10 cases. Exclusive systemic therapy was delivered to four patients; one patient with orbital IMT was managed by watchful waiting. After a median follow‐up of 33 months (range 5–124), eight (20%) recurrences/progressions occurred after surgery (seven after primary surgery and one after delayed surgery), after a median interval of 7 months (range 2–21), all in thoracic locations. The 3‐year overall and disease‐free survivals were 96.8% (95% CI: 79.2%–94.0%) and 77.4% (95% CI: 59.6%–88.1%), respectively. Relapses/progressions were more common in patients with a thoracic primary (p < .001) or after incomplete surgery with no adjuvant therapy (p = .027).ConclusionSurgery is effective in most cases of pediatric IMT. Systematic analysis of tyrosine kinase rearrangement is recommended. When the tumor is deemed only partially resectable to preserve organs and function, neoadjuvant therapy may be proposed to allow adequate conservative surgery.
A simple tree planting framework to improve climate, air pollution, health, and urban heat in vulnerable locations using non‐traditional partners
Authors: Hopkins Loren P. , January‐Bevers Deborah J. , Caton Erin K. , Campos Laura A. 
Published: December 2021

Societal Impact StatementPlanting trees is considered an effective method for climate change adaptation and mitigation. This framework provides a replicable blueprint to improve health, urban heat, flooding, and air pollution via a multisectoral, collaborative, environmental data‐driven approach. Native tree species with targeted ecosystem services are selected, and sites are strategically identified based on environmental and health benefits, with the intent of engaging community involvement through education and large‐scale tree plantings. Including non‐traditional partners in the framework provides heightened awareness of the relationship between climate change and health, thus catalyzing decision‐making regarding sustainable actions that reduce effects of climate change. This native tree planting framework is highly adaptable in other cities.Summary

A multidisciplinary framework is presented for a data‐driven, climate change adaptation and climate change and air pollution mitigation project. This framework leverages heightened awareness of the connections between climate change, air pollution, and health to expand the cadre and societal impacts of those working to intervene in resilience planning and implementation.
The framework, implemented in Houston, Texas, USA, beginning in 2019, consists of three parts: (1) identification of optimal native tree species for climate change adaptations and air pollution mitigation around variables important locally; (2) selection of large‐scale native tree planting locations where populations are already disproportionately experiencing flooding, increased heat, and air pollution‐related health effects that could be further exacerbated from climate change; and (3) engagement of multisectoral leadership broadened beyond those traditionally working on climate change resilience through heightening awareness of the link to human health.
Native tree species were identified that had the highest combination of absorption of carbon dioxide, other air pollutants, and water absorption (aiding in flood adaptation and air pollution/heat mitigation). Thousands of the top tree species were planted in locations that experience substantial flooding during large rain events, have high rates of health effects exacerbated by air pollution (e.g., cardiac arrest and asthma attacks), and experience multiple days of elevated heat and air pollution.
This multidisciplinary framework addresses a critical need to provide interventions accessible to the community; educate on the connection between climate change adaptation, air pollution mitigation, and health; and foster multisectoral leadership to accelerate local resilience actions.
Delayed radical prostatectomy after a period of active surveillance is not associated with the use of secondary treatments compared with immediate prostatectomy
Authors: Arcot Rohith , Cher Michael L. , Qi Ji , Linsell Susan M. , Dunn Rodney L. , George Arvin K. , Montie James E. , Ginsburg Kevin B. ,   for the Michigan Urological Surgery Improvement Collaborative
Published: December 2021

AbstractBackgroundWe evaluated the use of secondary treatments in men with grade group (GG) 1 PC following a period of active surveillance (AS) compared with men undergoing immediate radical prostatectomy (RP) to evaluate what is potentially lost in terms of cancer control, if a patient trials AS and transitions to treatment.MethodsWe reviewed the Michigan Urological Surgery Improvement Collaborative (MUSIC) registry for men with GG1 PC undergoing RP from April 2012 to July 2018. Men were classified into groups based on time from diagnosis to RP: immediate (surgery within 1 year of diagnosis) and delayed RP (surgery >1 year after initiation of AS). Time to secondary treatment was estimated using Kaplan–Meier curves and compared using the log‐rank test. A multivariable Cox proportional hazards model was fit to assess the association between timing of RP and use of secondary treatments. A chi‐squared test was used to assess the association between delayed RP and adverse pathology.ResultsWe identified 1878 men that underwent an RP during the study period, of which 1489 (79%) underwent immediate RP and 389 (21%) underwent delayed RP. The incidence of adverse pathology was higher in men with delayed versus immediate RP (49% vs. 36%, p < 0.0001, respectively). However, we noted only a small absolute difference in the estimated 24‐month secondary treatment‐free probability between men with delayed versus immediate RP (93% and 96%, respectively). On multivariable analysis, delayed RP was associated with increased use of secondary treatments (hazard ratio = 1.94, 95% confidence interval = 1.23–3.06, p = 0.004).ConclusionsThe use of secondary treatment after RP in men with GG1 PC undergoing immediate or delayed prostatectomy was rare. These data suggest that the burden of treatment is near equivalent in patients who progress to treatment on AS compared with those who underwent immediate RP.
A fast converging and concise algorithm for computing the departure points in semi‐Lagrangian weather and climate models
Authors: Diamantakis Michail , Váňa Filip 
Published: December 2021

AbstractAccurate calculation of departure points is crucial for the overall accuracy of a semi‐Lagrangian advection scheme. The iterative method used in the semi‐Lagrangian advection scheme of the ECMWF model IFS (Integrated Forecast System) is based on SETTLS (Stable Extrapolation Two‐Time‐Level Scheme). The scheme converges slowly due to the long timesteps that the spectral semi‐implicit, semi‐Lagrangian formulation permits: five iterations are needed for accurate determination of the departure points. Spherical coordinates increase the expense and complexity of the relevant code while computations become sensitive to arithmetic precision and require further approximations in the polar high‐curvature region. In this article, an accurate alternative, derived by reformulating the current SETTLS scheme on a geocentric Cartesian framework, is proposed. The new scheme simplifies considerably the computations by avoiding the update of the Lagrangian trajectory equations in spherical coordinates, which involve additional expensive metric terms, eliminates approximations, and is advantageous for single precision. Methods to accelerate the convergence of the departure points were also investigated. The most accurate and efficient approach was to start the SETTLS iterations from the departure point of the previous timestep. Testing the proposed method in high‐resolution global forecast and 4D‐Var analysis experiments yields equally accurate results as the existing method, while reducing the cost of the iterative scheme.
Chronic pulmonary aspergillosis in a patient with hyper‐IgE syndrome
Authors: Kasuga Keisuke , Nakamoto Keitaro , Doi Kazuyuki , Kurokawa Nozomi , Saraya Takeshi , Ishii Haruyuki 
Published: December 2021

AbstractHyperimmunoglobulin E (IgE) syndrome (HIES) is a rare disease with an unclear prognosis. We report a case of HIES comorbid with chronic pulmonary aspergillosis (CPA). A 19‐year‐old male was referred to our department with a medical history of bacterial pneumonia and skin infection. Laboratory data showed an elevated eosinophil count and serum IgE level. Chest computed tomography (CT) showed a pneumatocele and bronchiectasis. On the basis of the clinical and laboratory findings and genetic mutation analysis, we diagnosed him as having HIES. Fourteen months later, he complained of blood‐tinged sputum and haemoptysis. Chest CT showed pneumatocele wall thickening, fungus ball and consolidation. Serum Aspergillus precipitating antibody and serum galactomannan Aspergillus antigen were positive, and Aspergillus fumigatus was detected in the sputum. We diagnosed CPA and treated him using antifungal agents and bronchial artery embolization. CPA is a complication that requires attention in patients with HIES.
Sensor fault estimation and fault tolerant control for IT2 fuzzy system via sliding mode approach
Authors: Sun Xingjian , Kang Haobo , Ma Hongjun 
Published: December 2021

AbstractThe point of this article is the sensor fault estimation and fault‐tolerant controller design for IT2 fuzzy systems via sliding mode approach. In order to estimate accurately the system states and sensor faults, a novel proportional and derivative sliding mode observer is introduced, which provide more design freedom and eliminate the effects of sensor faults. By splitting the operating domain and estimating the membership functions, a set of relaxation stability conditions subject to the information of membership functions and system states are obtained. Then, a sliding mode controller in form of IT2 fuzzy model is designed to stabilize the closed‐loop systems. An example of bolt‐tightening tool model is considered to demonstrate the validity of the proposed results.
“Because we have lived it”: Chicanx/Latinx Youth Multimodal Literacies in Youth Participatory Action Research
Authors: González Ybarra Mónica 
Published: December 2021

AbstractThis article highlights how Chicanx/Latinx youth draw on their lived realities as lenses to guide their inquiry and share their findings in a Youth Participatory Action Research project. In this project, youth collected testimonios from residents and staff within their migrant housing community to better understand histories of migration and community building. Drawing on a critical multimodal analysis framework which centers Chicanx/Latinx youth literacies and epistemologies, this article focuses on how youth drew on their community cultural knowledge and lived experiences in multimodal creation to bring attention to sociopolitical issues they cared about and impacted their community.
3D Printed Biocatalytic Living Materials with Dual‐Network Reinforced Bioinks
Authors: He Fukun , Ou Yangteng , Liu Ji , Huang Qiu , Tang Bao , Xin Fengxue , Zhang Jing , Jiang Min , Chen Su , Yu Ziyi 
Published: December 2021

AbstractThe field of living materials seeks to harness living cells as microfactories that can construct a material itself or enhance the performance of material in some manner. While recent advances in 3D printing allow microbe manipulation to create bespoke living materials, the effective coupling of these living components in reinforced bioink designs remains a major challenge due to the difficulty in building a robust and cell‐friendly microenvironment. Here, a type of dual‐network bioink is reported for the 3D printing of living materials with enhanced biocatalysis capabilities, where bioinks are readily printable and provide a biocompatible environment along with desirable mechanical performance. It is demonstrated that integrating microbes into these bioinks enables the direct printing of catalytically living materials with high cell viability and maintains metabolic activity, which those living materials can be preserved and reused. Further, a bacteria‐algae coculture system is fabricated for the bioremediation of chemicals, giving rise to its potential field applications.