bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adenosquamous Carcinoma of the Cervix: A Population-Based Analysis
Authors: Cui Pengfei , Cong Xiaofeng , Chen Chen , Yang Lei , Liu Ziling 
Published: July 2021

BackgroundDue to the rarity of adenosquamous carcinoma of the cervix (ASCC), studies on the incidence, prognostic factors, and treatment outcomes of ASCC remain scarce. Therefore, we performed a retrospective population-based study to systematically investigate the characteristics of ASCC patients.MethodsPatients with a histopathologically confirmed diagnosis of ASCC were enrolled from the Surveillance, Epidemiology, and End Results database between 1975 and 2016. Univariate and multivariate Cox regression analyses were performed to identify the potential predictors of cancer-specific survival (CSS) in patients with ASCC. Selected variables were integrated to establish a predictive nomogram and the predictive performance of the nomogram was estimated using Harrell’s concordance index (C-index), calibration curve, and decision curve analysis (DCA).ResultsA total of 1142 ASCC patients were identified and included in this study and were further randomized into the training and validation cohorts in a 7:3 ratio. The age-adjusted incidence of ASCC declined from 0.19 to 0.09 cases per 100,000 person-years between 2000 and 2017, with an annual percentage change of -4.05% (P&lt;0.05). We identified age, tumor grade, FIGO stage, tumor size, and surgical procedure as independent predictors for CSS in ASCC patients and constructed a nomogram to predict the 3- and 5-year CSS using these prognostic factors. The calibration curve indicated an outstanding consistency between the nomogram prediction and actual observation in both the training and testing cohorts. The C-index was 0.7916 (95% CI: 0.7990-0.8042) and 0.8148 (95% CI: 0.7954-0.8342) for the training and testing cohorts, respectively, indicating an excellent discrimination ability of the nomogram. The DCA showed that the nomogram exhibited more clinical benefits than the FIGO staging system.ConclusionsWe established and validated an accurate predictive nomogram for ASCC patients based on several clinical characteristics. This model might serve as a useful tool for clinicians to estimate the prognosis of ASCC patients.
Reduction of Duration of Antibiotic Therapy for Suspected Early-Onset Sepsis in Late-Preterm and Term Newborns After Implementation of a Procalcitonin-Guided Algorithm: A Population-Based Study in Central Switzerland
Authors: Zihlmann-Ji Jennifer , Braun Christian , Buettcher Michael , Hodel Markus , Lehnick Dirk , Stocker Martin 
Published: July 2021

Background: Suspected early-onset sepsis (EOS) is the main reason for antibiotic therapy at the start of life. Prolonged antibiotic therapy for culture-negative sepsis is often reported. Antibiotic stewardship is mandatory due to the potential negative effects of unnecessary antibiotics. Procalcitonin (PCT)-guided therapy is one possible strategy with published evidence to shorten antibiotic therapy. The aim of this study is to analyze the feasibility and the performance of the published PCT-algorithm in the clinical setting without study support.Methods: This is a retrospective, population-based study regarding duration of antibiotic therapy for suspected EOS in Central Switzerland between 2014 and 2018. All neonates &gt;34 0/7 weeks of gestational age started on antibiotic therapy for suspected EOS within the first 3 calendar days of life were included. The Procalcitonin-guided algorithm according to the NeoPInS study was used as strategy to determine duration of antibiotic therapy.Results: In a population-based cohort of 35,642 life born neonates, the duration of antibiotic therapy of 879 neonates (2.5% of the cohort) treated for suspected EOS was 4 calendar days (median, IQR 2–5). We observed a statistically significant reduction from 4 (median, IQR 3–6) to 3 calendar days (median, IQR 2–4) from 2014 to 2018. Duration of antibiotic therapy was independent of gestational age (late-preterm vs. term neonates), of the presence of risk factors or clinical signs, but dependent on the presence of abnormal laboratory measurements (C-reactive protein &gt; 10 mg/l or leukocytopenia &lt;5 Giga/l) before start of antibiotic therapy (p &lt; 0.01).Conclusions: PCT-guided therapy using the NeoPInS algorithm is feasible and may lead to reduced duration of antibiotic therapy for suspected EOS as reported in the original study. We observed a learning curve to the new algorithm which may be explained as change process. The use of biomarker to guide duration of antibiotic therapy for suspected EOS may have unintended consequences with prolongation of antibiotic therapy in some cases.
Differential Dermatologic Adverse Events Associated With Checkpoint Inhibitor Monotherapy and Combination Therapy: A Meta-Analysis of Randomized Control Trials
Authors: Ge Yang , Zhang Huiyun , Weygant Nathaniel , Yao Jiannan 
Published: July 2021

Background: As immune checkpoint inhibitors (ICIs) transition to the forefront of cancer treatment, a better understanding of immune related adverse events (IRAEs) is essential to promote safe clinical practice. Dermatologic adverse events are the most common IRAEs and can lead to drug withdrawal and decreased quality of life. This meta-analysis aimed to investigate the risk of the most prevalent dermatologic adverse events (pruritus and rash) among various ICI treatment regimens.Methods: A systematic search of electronic databases was performed to identify qualified randomized controlled trials (RCTs). Data for any grade and high grade pruritus and rash were extracted for meta-analysis. Two reviewers independently assessed methodological quality. The relative risk summary and 95% confidence interval were calculated.Results: 50 RCTs involving 29941 patients were analyzed. The risk of pruritus (2.15 and 4.21 relative risk respectively) and rash (1.61 and 3.89 relative risk respectively) developing from CTLA-4 or PD-1/-L1 inhibitor were increased compared to placebo, but this effect was not dose-dependent. PD-1/-L1 plus CTLA-4 inhibitor was associated with increased risk of pruritus (1.76 and 0.98 relative risk respectively) and rash (1.72 and 1.37 relative risk respectively) compared to either monotherapy. Compared with CTLA-4 inhibitor, PD-1/-L1 inhibitor had a significantly decreased risk of pruritus and rash in both monotherapy and combination therapy (0.65 and 0.29 relative risk respectively). No significant difference was found between PD-1/-L1 inhibitor combined with chemotherapy and PD-1/-L1 monotherapy in any grade and high grade rash (0.84 and 1.43 relative risk respectively). In subgroup analyses, PD-1 inhibitor was associated with reduced risk of pruritus and rash compared to PD-L1 inhibitor.Conclusion: Our meta-analysis demonstrates a better safety profile for PD-1/-L1 inhibitor compared to CTLA-4 inhibitor in terms of pruritus and rash among both monotherapy and multiple combination therapies. PD-L1 inhibitor may contribute to an increased risk of pruritus and rash compared to PD-1 inhibitor.
Cost-Efficient Hybrid WDM-MDM-Ro-FSO System for Broadband Services in Hospitals
Authors: Liang Peidong , Zhang Chentao , Nebhen Jamel , Chaudhary Sushank , Tang Xuan 
Published: July 2021

The expansion of high-speed communication needs due to explosive growth of subscribers each year has led the researchers to design the next generation communication systems which can cope with the current growing demand. Millimeter waves, operated within the range of 30 GHz to 300 GHz, can become potential carrier for delivering large amount of data. However, in hospital scenarios, these radio waves are subjected to strict regulations due to direct impact on patients’ health as well as high interference with other medical devices which again imposes critical challenge on patients. Thus, it is a challenge for the researchers to provide communication/broadband services for transmission of such sensitive biomedical sensor data in hospitals locations. Radio over Free space (Ro-FSO) systems may become the attractive solution to deliver millimeter waves over free space link with high speed. Further, to expand the capacity of Ro-FSO systems, mode division multiplexing (MDM) plays a vital role in addition to wavelength division multiplexing (WDM) scheme. In this work, we have demonstrated the MDM-WDM scheme to deliver four channels with each one having the capacity of 10 Gbps up-converted to 40 GHz over FSO link which is suitable for providing broadband and communication services within the hospital premises. Moreover, the proposed WDM-MDM-Ro-FSO link is evaluated under different fog conditions.
Can Psychosocial Intervention Suppress Testosterone and Triglycerides Among Women With Polycystic Ovary Syndrome? A Feasibility Trial
Authors: Yin Margaret X. C. , Du L. B. , Zou X. N. , Fung Y. L. , Sun Y. Y. , Chan Celia H. Y. , Chan Cecilia L. W. 
Published: July 2021

Women with polycystic ovary syndrome (PCOS) suffer significant psychological distress, which may activate the hypothalamus-pituitary-ovary axis and further affect their physiological state. They often experience elevated levels of testosterone and triglycerides. Considering reports of psychological distress among women with PCOS, this study aimed to develop a psychosocial intervention to improve their emotional and physical health, particularly in Chinese society. This pilot study employed the Integrative Body-Mind-Spirit (I-BMS) intervention model for women with PCOS in China. After a 2 h health information session, 18 participants were randomly assigned to the I-BMS group (9) or the control group (9). The intervention group received 6 weekly, 3 h I-BMS sessions. Pre- and post-blood tests and psychosocial questionnaires were collected from all participants. Retention to treatment was high with 79.6% treatment adherence gained and an overall average of five sessions completed. Compared with the control group, depression and anxiety symptoms reduced significantly for those in the intervention group (d = −1.24, p &lt; 0.05 and d = –1.33, p &lt; 0.01), their health-related quality of life improved significantly (d = 1.02, p &lt; 0.01) both at post-intervention and 3 month follow-up, and their testosterone and triglycerides levels reduced significantly (d = −0.97, p &lt; 0.001 and d = –0.41, p &lt; 0.05) after joining the intervention. The I-BMS model is feasible and appears promising in improving psychological health, and reducing testosterone and triglyceride levels, in women with PCOS in China.Clinical Trial Registration:www.chictr.org.cn, identifier ChiCTR1900027606.
Validity and Cultural Generalisability of a 5-Minute AI-Based, Computerised Cognitive Assessment in Mild Cognitive Impairment and Alzheimer's Dementia
Authors: Kalafatis Chris , Modarres Mohammad Hadi , Apostolou Panos , Marefat Haniye , Khanbagi Mahdiyeh , Karimi Hamed , Vahabi Zahra , Aarsland Dag , Khaligh-Razavi Seyed-Mahdi 
Published: July 2021

Introduction:Early detection and monitoring of mild cognitive impairment (MCI) and Alzheimer's Disease (AD) patients are key to tackling dementia and providing benefits to patients, caregivers, healthcare providers and society. We developed the Integrated Cognitive Assessment (ICA); a 5-min, language independent computerised cognitive test that employs an Artificial Intelligence (AI) model to improve its accuracy in detecting cognitive impairment. In this study, we aimed to evaluate the generalisability of the ICA in detecting cognitive impairment in MCI and mild AD patients.Methods:We studied the ICA in 230 participants. 95 healthy volunteers, 80 MCI, and 55 mild AD participants completed the ICA, Montreal Cognitive Assessment (MoCA) and Addenbrooke's Cognitive Examination (ACE) cognitive tests.Results:The ICA demonstrated convergent validity with MoCA (Pearson r=0.58, p&lt;0.0001) and ACE (r=0.62, p&lt;0.0001). The ICA AI model was able to detect cognitive impairment with an AUC of 81% for MCI patients, and 88% for mild AD patients. The AI model demonstrated improved performance with increased training data and showed generalisability in performance from one population to another. The ICA correlation of 0.17 (p= 0.01) with education years is considerably smaller than that of MoCA (r= 0.34,p&lt; 0.0001) and ACE (r= 0.41,p&lt; 0.0001) which displayed significant correlations. In a separate study the ICA demonstrated no significant practise effect over the duration of the study.Discussion:The ICA can support clinicians by aiding accurate diagnosis of MCI and AD and is appropriate for large-scale screening of cognitive impairment. The ICA is unbiased by differences in language, culture, and education.
The 100 Top-Cited Studies on Dyslexia Research: A Bibliometric Analysis
Authors: Zhang Shijie , Fan Hong , Zhang Yonggang 
Published: July 2021

Background: Citation analysis is a type of quantitative and bibliometric analytic method designed to rank papers based on their citation counts. Over the last few decades, the research on dyslexia has made some progress which helps us to assess this disease, but a citation analysis on dyslexia that reflects these advances is lacking.Methods: A retrospective bibliometric analysis was performed using the Web of Science Core Collection database. The 100 top-cited studies on dyslexia were retrieved after reviewing abstracts or full-texts to May 20th, 2021. Data from the 100 top-cited studies were subsequently extracted and analyzed.Results: The 100 top-cited studies on dyslexia were cited between 245 to 1,456 times, with a median citation count of 345. These studies were published in 50 different journals, with the “Proceedings of the National Academy of Sciences of the United States of America” having published the most (n = 10). The studies were published between 1973 and 2012 and the most prolific year in terms of number of publications was 2000. Eleven countries contributed to the 100 top-cited studies, and nearly 75% articles were either from the USA (n = 53) or United Kingdom (n = 21). Eighteen researchers published at least two different studies of the 100 top-cited list as the first author. Furthermore, 71 studies were published as an original research article, 28 studies were review articles, and one study was published as an editorial material. Finally, “Psychology” was the most frequent study category.Conclusions: This analysis provides a better understanding on dyslexia and may help doctors, researchers, and stakeholders to achieve a more comprehensive understanding of classic studies, new discoveries, and trends regarding this research field, thus promoting ideas for future investigation.
Mental Health Symptoms, Binge Drinking, and the Experience of Abuse During the COVID-19 Lockdown in Mexico
Authors: Morales Chainé Silvia , López Montoya Alejandra , Bosch Maldonado Alejandro , Beristain Aguirre Ana , Robles García Rebeca , Garibay Rubio Carlos Rodrigo , Astudillo García Claudia Iveth , Lira Chávez Isaura Angélica , Rangel Gómez María Gudelia 
Published: July 2021

Background: The health crisis associated with the COVID-19 pandemic is causally linked to negative mental health symptoms in the same way as other diseases such as Ebola.Objective: The purpose of this paper is to describe the relationship between mental health symptoms, binge drinking, and the experience of abuse during the COVID-19 lockdown.Method: We surveyed 9,361 participants, all Mexican, with an average age of 33 years old (SD = 10.86). In this group of people, we found out that 59% were single (5,523), 71% were women (6,693). Forty-six percentage were complying with lockdown procedures (4,286), 50% were partially complying (4,682), and 4% were not complying at all (393). The invitation to participate was open from April 24th to April 30th during the second stage of the pandemic in Mexico, in 2020, characterized by voluntary complete lockdown staying at home. Thus, we used a cross-sectional online survey design to assess mental health risk factors related to the COVID-19 pandemic. The survey was available on a WebApp designed by Linux®, PHP®, HTML®, CSS®, and JavaScript®. We calculated descriptive and inferential analysis to describe the mental health average distribution as a function of the lockdown, binge drinking, and experience of abuse. To calculate the reliability and validation of the subscales, we used Cronbach's Alpha and Factor Loading. We run the confirmatory factor loading analysis, and we described the relationship between each latent variable and its item factor load, obtained through structural modeling equations, derived from 179 iterations and 207 parameters (t[1,171] = 28,079.418, p &lt; 0.001). We got a CFI of 0.947, a TLC of 0.940, an RMSEA of 0.049 (0.049–0.050), and an SRMR of 0.048.Findings: The results indicated that reported attitudes such as avoidance, sadness, withdrawal, anger, and anxiety were associated with acute stress, which was linked to an anxiety condition caused by uncertainty about achieving or maintaining overall good health.Discussion and Prospects: People in lockdown mentioned a sudden increase in alcohol consumption. They lived episodes of physical and emotional abuse, in contrast with those who stated that they did not go into lockdown or consume alcohol, or experienced abuse.Limitations: Further studies should diagnose mental health conditions as part of the impact of COVID-19, ensure their follow-up, and assess the effect of providing remote psychological care. There is a need to explore methods to curb the increase in the number of people affected by post-traumatic stress disorder.
HAPPY LIFE STYLE (HAYATAN TAYYIBAH) FROM THE QUR'ANIC PERSPECTIVE
Authors: Hadi Abdul 
Published: July 2021

Islamic lifestyle mean is amount of topics and issues that satisfies Islam in human life, if we want to see that our lifestyle Islamic or not, we have to put some standart to evaluate it. But beside that, we must know rightly the concept and reality of the Islamic way of life. The standard of behavior in the Muslim community should be based on the principles of Islamic teachings, and the most important criteria for Islamic lifestyle based on the hole submission of God and the rule of Islamic values ​​in life. So we should be base on Islamic and Quranic teaching in personal life and social ones, and in this case we can be assured that Islam being our life style.
Yang dimaksud dengan gaya hidup islami adalah banyaknya topik dan isu yang memuaskan Islam dalam kehidupan manusia, jika kita ingin melihat apakah gaya hidup islami atau tidak, kita harus menempatkan suatu standart untuk mengevaluasinya. Namun disamping itu, kita harus mengetahui dengan benar konsep dan realita jalan hidup Islam. Standar perilaku dalam masyarakat Muslim harus didasarkan pada prinsip-prinsip ajaran Islam, dan kriteria terpenting gaya hidup Islami berdasarkan lubang ketaatan Tuhan dan kaidah nilai-nilai Islam dalam kehidupan. Jadi kita harus mendasarkan pada ajaran Islam dan Alquran dalam kehidupan pribadi dan sosial, dan dalam hal ini kita dapat yakin bahwa Islam menjadi gaya hidup kita.
AHLUSSUNAH WAL JAMAAH'S POLITICAL PRACTICES IN POST-REFORM INDONESIA
Authors: Zubaidi Ahmad 
Published: July 2021

Islamic politics in Indonesia is very distinctive and has characteristics as a reflection of Indonesian Muslims who understand ahlussunnah wal jamaah so that the aspect of compromise and promoting togetherness, and attaching importance to stability is undeniable. However, that was before, later after the reformation, when the faucet of freedom was opened in Indonesia, many political ideologies entered Indonesia. They tried to change the established Indonesian political order, such as the emergence of the sharia formalization movement, the desire to establish an Islamic state, and the Islamic caliphate. The political activity of this model is increasingly visible in the era of President Jokowidodo as a symbol of resistance. This paper tries to elaborate and analyze with a descriptive analysis system on the phenomena in post-reform Indonesia. It is interesting because there are symptoms that the political doctrine of Aswaja will be defeated by the momentary political doctrines and the doctrines of khilafahism. However, during this upheaval, Aswaja's power and doctrine proved to endure despite the worrying erosion.

Politik Islam di Indonesia sangat khas dan berkarakteristik sebagai cerminan umat Islam Indonesia yang berpaham ahlussunnah wal jamaah, sehingga aspek kompromi dan mengedepankan kebersamaan dan mementingkan stabilitas angat kentara. Tapi itu dulu, belakangan pasca refeormasi, ketika kran kebebasan dibuka di Indonesia, banyal ideology politik masuk ke Indonesia dan berusaha merubah tatanan politik indonnesia yang sudah mapan, seperti munculnya gerakan formalisasi syariah, keinginan mendirikan Negara Islam, dan khiafah islamiyah. Bahkan aktifitas politik model ini semakin kentara di ere Presiden Jokowidodo sebagai symbol perlawanan. Tulisan ini mencoba mengelabirasi dan menganalisis dengan system analisis deskriptif terhadap fenomena yang terjadi di Indonesia pasca reformasi. Hal ini menarik karena ada gejala doktrin politik aswaja akan terkalahkan oleh doktrin politik sesaat dan doktin-doktin khilafihisme. Namun, di tengah pergolakan ini, kekuatan aswaja dan doktrinnya terbukti dapat bertahan walau di tengah erosi yang mengkhawatirkan.
REVITALIZATION OF WAQF MANAGEMENT FOR SOCIAL ECONOMIC DEVELOPMENT OF EAST LUWU
Authors: Putra Trisno Wardy , Fildayanti Devita Ayu 
Published: July 2021

Waqf is one of the sources of funds that has the potential to develop the people's economy. Even history proves that waqf that is maintained and developed productively is very helpful for the interests of the community.This study aims to determine the waqf management system in Tawakua Village, Angkona District, East Luwu Regency. The method used in this research is descriptive qualitative with a phenomenological approach. Data collection techniques through interview studies to 5 informants. The results of this study indicate that the management of waqf assets is managed directly by the village, and administration of the waqf pledge deed is carried out at KUA Angkona District. However, the role of waqf as a socio-economic development has not been optimal due to the lack of public knowledge and a lack of qualified human resources in the field of waqf. Therefore, it is necessary to revitalize the management of waqf so that the function of waqf as an instrument of economic development can be achieved.
Wakaf menjadi salah satu sumber dana yang memiliki potensi dalam pengembangan ekonomi umat. Bahkan sejarah membuktikan bahwa wakaf yang dipelihara dan dikembangkan secara produktifsangat membantu kepentingan masyarakat.Penelitian ini bertujuan untuk mengetahui sistem pengelolaan wakaf di Desa Tawakua Kecamatan Angkona Kabupaten Luwu Timur. Metode yang digunakan dalam penelitian ini yaitu kualitatif deskriptif dengan pendekatan fenomenologi. Teknik pengambilan data melalui studi wawancara kepada 5 informan. Hasil penelitian ini menunjukkan bahwa pengelolaan harta benda wakaf dikelola secara langsung oleh desa, dan pengurusan administrasi akta ikrar wakaf dilakukan di KUA Kecamatan Angkona. Namun peran wakaf sebagai pembangunan sosial ekonomi belum optimal karena minimnya pengetahuan masyarakat dan kurangnya sumber daya manusia yang mumpuni di bidang wakaf. Oleh karena itu revitalisasi pengelolaan wakaf perlu dilakukan agar fungsi wakaf sebagai instrumen pembangunan ekonomi dapat tercapai.