bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Motif «My Strength is Made Perfect in Weakness» in N. V. Gogol’s Epistolary Heritage of the 1840s
Authors: Смирнов Василий Андреевич 
Published: December 2021

Статья посвящена исследованию библейского мотива «сила Моя в немощи совершается» в письмах Н. В. Гоголя 1840х гг. Источником данного мотива является фрагмент Второго послания апостола Павла к Коринфянам. Определяются особенности авторской интерпретации апостольского послания, выявляются основные способы его включения в эпистолярий Гоголя (прямое цитирование, аллюзия).
The article is devoted to the study of the biblical motive «My strength is made perfect in weakness» in the letters of N. V. Gogol in the 1840s. The source of this motive is a fragment of the second epistle of the Apostle Paul to the Corinthians. The author defines the peculiarities of the author’s interpretation of the apostolic epistle, identifies the main ways of its inclusion in Gogol’s epistolary (direct citation, allusion).
Christianity in Bakhtin. (Chapter 1)
Authors: Каутс Рут 
Published: December 2021

Настоящая публикация продолжает цикл переводов, цель которых - познакомить русскоязычного читателя с содержанием наиболее важных разделов исследования Рут Каутс (Ruth Coates) «Христианство в творчестве Бахтина» («Christianity in Bakhtin»). Во второй части вступления она перечисляет работы западных и российских исследователей творчества Бахтина (монографии, статьи, эссе), к выводам которых относится довольно скептически и разъясняет свою попытку оспорить некоторые трактовки и выводы, а также показать их надуманность и поверхностность. Наибольший интерес для нее представляют основательные исследования, и сама она настраивает читателя на свой комплексный и практичный подход в работе. В то же время, четко обозначая цель своего исследования, автор смело утверждает, что ей самой «чуждо православие», и в своём исследовании она совершает попытку ещё и углубить свои знания.
The present publication continues a series of translations that aim to introduce the Russian-speaking reader to the contents of the most important sections of Ruth Coates' study, Christianity in Bakhtin. In the second part of the introduction, she lists the works of Western and Russian scholars of Bakhtin's work (monographs, articles, essays) to whose conclusions she is rather sceptical and explains her attempt to challenge certain interpretations and conclusions and to show them to be far-fetched and superficial. She is most interested in solid research and sets the reader up for her comprehensive and practical approach to her work. At the same time, while clearly stating the aim of her research, the author boldly states that she herself is "alien to Orthodoxy" and in her research she also attempts to deepen her knowledge.
Epidemiology of Leprosy in Childhood: A Retrospective Study
Authors: Rusmawardiana  , Fifa Argentina  , Indri Widya Sari  
Published: December 2021

Background: Children are the group most susceptible to Mycobacterium leprae infection. The proportion of new leprosy cases in children is indicator of successful leprosy elimination program from World Health Organization (WHO), so this study would like to know the epidemiology of pediatric leprosy at Dermatology and Venereology Polyclinic, Dr. Mohammad Hoesin Palembang.
Methods: Retrospective study of all new cases of leprosy in children (0-17 years) who came to Dermatology and Venereology Polyclinic, Dr. Mohammad Hoesin Palembang from January 2017 to December 2020.
Results: There were 10 pediatric patients (7.58%) from 132 new leprosy cases. Most cases (40%) were in the 15-17 age group. There are more male than female. Most types of leprosy are BL (60%) followed by TT (20%). Manifestations of hyperpigmented skin patches and nervous disorders, grade 1 disability, and type 2 leprosy reactions are mostly found in type BL leprosy. The duration of illness 6-12 months has a grade 1 disability (30%). The history of positive contact came from same household in 3 cases (30%) with 7 people (70%) domiciled in Palembang. All cases received Multidrug Therapy (MDT) treatment according to WHO guidelines.
Conclusion: Found 10 new cases of leprosy in children in Dermatology and Venereology Polyclinic Dr. Moh. Hoesin Palembang for four years, especially in the 15-17 age group, with the most cases being type BL leprosy. Household contact still plays an important role in leprosy transmission.
EVALUATION FUNCTIONAL OUTCOME OF HELICAL FIXATION PFN A2 IN PROXIMAL FEMUR FRACTURE IN ELDERLY
Authors: Singh Sawai , Chander Ram 
Published: December 2021

Background: Intertrochantric fractures are the most frequently operated fractures and has the highest mortality and morbidity rates. Evaluation functional outcome of helical fixation pfn a2 in proximal femur fracture in elderly
Methods: Hospital based prospective randomized comparative study conducted on 30 patients with Close stable &unstable intertrochanteric femur fracture.
Results: As per HHS, we have found that 76.67% cases (23) under excellent category and 20.00% (6) good and 3.33% (1) fair of HHS.
Conclusion: We can conclude that the PROXIMAL FEMORAL NAIL ANTIROTATION2 is after proper training and technique a safe and easy implant option for treatment of complex peritertrochanteric fractures.
Keywords: HHS, Femur, fracture
A Study on Internship Student Debriefing Materials in ‘Merdeka Belajar Kampus Merdeka’ Program
Authors: Handrianto Budi 
Published: December 2021

<em>The VUCAS era as it is today has brought about changes in attitudes and human interactions at work. A person’s competancy is demanded to be acquired more than one or what is so called, multitasking. Whilst, higher education Institutions does not prepare these competencies for graduate students. The industrial world is also overwhelmed by the quality of untrained new employees. There for, it is esential to create program in order to link and match between Higher Education Institutions Programs and the need of industrial world. The Ministry of Education and Culture has created a 3 semesters training program outside its study program, one of which is an internship in companies. Due to this, we design debriefing material in accordance to the industrial perspective. This research aims to obtain perspectives on the material from the industry. This qualitative research was conducted using in-depth interviews, both in person and online to gather information from industry players. The results obtained will be materials that must be given to students during the debriefing, there are two important materials to be given, namely; knowledge and work attitude. Knowledge includes: company organization, job duties and responsibilities, remuneration systems, industrial relations, employee development and management systems. Work attitudes include general values such as integrity, discipline, leadership, team work, interpersonal skills, analitical competency, open mindedness, emotional quotient (EQ), burning desire/passion and time management skills and rules in work (manner).</em>
PENERAPAN PROGRAM PENCEGAHAN COVID-19 PADA ANAK BERBASIS DARING DI DESA MARGAJAYA RT/RW 03/05 KECAMATAN BOGOR BARAT
Authors: Jasmin Rizaldy , Asnifatima Andi 
Published: December 2021

Kelurahan Margajaya merupakan salah satu daerah yang terletak di Kecamatan Kota Bogor Barat Kota Bogor Provinsi Jawa Barat, Indonesia. Masyarakat di daerah tersebut, sebagian besar mendirikan usaha warung/toko disekitar tempat tinggalnya dan hampir seluruh masyarakat kelurahan masyarakatnya menganut agama islam. Pada tanggal 17 Agustus 2020 sampai tanggal 17 September 2020 Alhamdulillah kami telah melaksanakan program pengabdian masyarakat, selama kurang lebih 1 bulan di Jalan Pemuda Caringin Kelurahan Margajaya Kecamatan Kota Bogor Barat. Adapun tujuan dari pelaksanaan program ini untuk memberikan informasi yang valid terkait Covid-19 dan cara pencegahannya dimana sasaran utama dalam program ini yaitu Anak-anak. Alasan menjadikan anak sebagai sasaran utama program ini karena anak-anak merupakan salah satu subjek yang rentan terjangkit Covid-19 akibat minimnya informasi yang didapatkan. Dalam mengatasi masalah tersebut kami mengadakan Penyuluhan tentang Covid-19 secara umum, Penyuluhan penggunaan masker dan Penyuluhan asupan gizi seimbang yang dilaksanakan secara daring menggunakan aplikasi whatsapp sebagai media penyebaran informasi. Hasil yang didapatkan dari program tersebut yaitu peningkatan pengetahuan orang tua dan anak terkait Covid-19 dan cara pencegahannya, sehingga orang tua dapat membiasakan anak-anak mereka melakukan pencegahan secara mandiri terhadap Covid-19.
Estrategias de prevención para disminuir la transmisión vertical del virus de inmunodeficiencia humana durante la gestación
Authors: Moreno Reyes Katherin Faviola , Ayala Peralta Felix Dasio , Velásquez Vásquez Carlos 
Published: December 2021

El embarazo en una mujer que vive con el VIH continúa siendo un problema importante de salud que involucra no solo a la gestante si no al producto de la gestación por el alto riesgo de transmitir del virus durante el embarazo, el momento del parto y la lactancia materna.
A pesar de los años transcurridos, los estudios seleccionados siguen reportando que la reducción de la transmisión vertical del VIH se logra con el diagnóstico temprano de la infección en la gestante, disminuyendo la carga viral materna mediante el uso de terapia antirretroviral en el embarazo y en el momento del parto, el nacimiento por cesárea electiva, la supresión de la lactancia materna y la profilaxis antirretroviral en el recién nacido.
IMPACT OF COVID 19 PANDEMIC ON PROJECT PORTFOLIO MANAGEMENT-A CASE STUDY ON CONSTRUCTION INDUSTRY IN SOUTHERN INDIA
Authors: Krishnan Ajay , S Ajithkumar , G Manishankar , K Upendra , A Kabilan , Muralidhar P 
Published: December 2021

In India, Project Portfolio Management (PPM) is in practice as a tool for prioritizing and managing real estate projects in construction organizations. But due to insufficient funding, improper judgment of experts during the crisis situation, the selection of optimal project portfolio prototype can be viewed as a risk based decision making process involving various risk factors. The objective of this study is to analyze the importance of project portfolio management and the risks associated with it in the construction industry taking into account the impact of novel corona virus COVID 19. This research identifies the adoption of more consistent project governance, risk management techniques and way more careful project portfolio management as the core area of study. A conceptual framework for Project Portfolio Management is also designed after analyzing various parameters of Project Portfolio Management of construction industry with the help of Bayesian framework. The key motive for undertaking this part of examination on real estate sector of Indian construction industry in southern part of India to reduce the impacts and increase the return on investment from the projects by mitigating the effect of risk factors associated in the projects. Project Portfolio Management tools and techniques are very useful for managing multiple construction projects.
DNA Methylation Modification Map to Predict Tumor Molecular Subtypes and Efficacy of Immunotherapy in Bladder Cancer
Authors: Ye Fangdie , Liang Yingchun , Hu Jimeng , Hu Yun , Liu Yufei , Cheng Zhang , Ou Yuxi , Xu Chenyang , Jiang Haowen 
Published: December 2021

Background: Considering the heterogeneity and complexity of epigenetic regulation in bladder cancer, the underlying mechanisms of global DNA methylation modification in the immune microenvironment must be investigated to predict the prognosis outcomes and clinical response to immunotherapy.Methods: We systematically assessed the DNA methylation modes of 985 integrated bladder cancer samples with the unsupervised clustering algorithm. Subsequently, these DNA methylation modes were analyzed for their correlations with features of the immune microenvironment. The principal analysis algorithm was performed to calculate the DMRscores of each samples for qualification analysis.Findings: Three DNA methylation modes were revealed among 985 bladder cancer samples, and these modes are related to diverse clinical outcomes and several immune microenvironment phenotypes, e.g., immune-desert, immune-inflamed, and immune-excluded ones. Then patients were classified into high- and low-DMRscore subgroups according to the DMRscore, which was calculated based on the expression of DNA methylation related genes (DMRGs). Patients with the low-DMRscore subgroup presented a prominent survival advantage that was significantly correlated to the immune-inflamed phenotype. Further analysis revealed that patients with low DMRscores exhibited less TP53 wild mutation, lower cancer stage and molecular subtypes were mainly papillary subtypes. In addition, an independent immunotherapy cohort confirmed that DMRscore could serve as a signature to predict prognosis outcomes and immune responses.Conclusion: Global DNA methylation modes can be used to predict the immunophenotypes, aggressiveness, and immune responses of bladder cancer. DNA methylation status assessments will strengthen our insights into the features of the immune microenvironment and promote the development of more effective treatment strategies.
Renal Function Effect on the Association Between Body Mass Index and Mortality Risk After Acute Myocardial Infarction
Authors: Kang Shin Yeong , Kim Weon , Kim Jin Sug , Jeong Kyung Hwan , Jeong Myung Ho , Hwang Jin Yong , Hwang Hyeon Seok 
Published: December 2021

Background: Body mass index (BMI) is a critical determinant of mortality after acute myocardial infarction (AMI), and higher BMI is associated with survival benefit in patients with renal impairment. However, there are no studies investigating the interactive effects of BMI and renal function on mortality risk after AMI occurrence.Methods: We enrolled 12,647 AMI patients from Korea Acute Myocardial Infarction Registry between November 2011 and December 2015. Patients were categorized based on estimated Glomerular Filtration Rate (eGFR) and BMI. The primary endpoint was all-cause mortality after AMI treatment.Results: Within each renal function category, the absolute mortality rate was decreased in patients with higher BMI. However, the adjusted hazard ratio (HR) of all-cause mortality for higher BMI was decreased as renal function worsened [adjusted HR (95% confidence interval) at BMI ≥ 25 kg/m2: 0.63 (0.41–0.99), 0.76 (0.59–0.97), and 0.84 (0.65–1.08) for patients with eGFR ≥ 90, 90–45, and &lt;45 mL/min/1.73 m2, respectively]. There was a significant interaction between BMI and renal function (P for interaction = 0.010). The protective effect of higher BMI was preserved against non-cardiac death and it was also decreased with lowering eGFR in competing risks models [adjusted HR at BMI ≥25 kg/m2: 0.38 (0.18–0.83), 0.76 (0.59–0.97), and 0.84 (0.65–1.08) for patients with eGFR ≥ 90, 90–45, and &lt;45 mL/min/1.73 m2, respectively; P for interaction = 0.03]. However, renal function did not significantly affect the association between BMI and risk of cardiac death (P for interaction = 0.20).Conclusions: The effect of BMI on the mortality risk after AMI was dependent on renal function. The association between greater BMI and survival benefit was weakened as renal function was decreased. In addition, the negative effect of renal function on the BMI – mortality association was pronounced in the non-cardiac death.
Moho Geometry of the Okinawa Trough Based on Gravity Inversion and Its Implications on the Crustal Nature and Tectonic Evolution
Authors: Zhang Liang , Luan Xiwu 
Published: December 2021

The Okinawa Trough (OT) is an incipient back-arc basin, but its crustal nature is still controversial. Gravity inversion along with sediment and lithospheric mantle density modeling are used to map the regional Moho depth and crustal thickness variations of the OT and its adjacent areas. The gravity inversion result shows that the crustal thicknesses are 17–22 km at the northern OT, 11–19 km at the central OT, and 7–19 km at the southern OT. Because of the crust with a thickness larger than 17 km, the slow southward arc movement, and scarce contemporaneous volcanisms, the northern OT should be in the stage of early back-arc extension. All of the moderate crustal thickness, high heat flow, and intense volcanism at the central OT indicate that this region is probably in the transitional stage from the back-arc rifting to the oceanic spreading. A crust that is only 7 km thick, lithosphere strength as low as the mid-ocean ridge, and MORB-similar basalts at the southern OT demonstrate that the southern OT is at the early stage of seafloor spreading.
Functional and Binding H1N1pdm09-Specific Antibody Responses in Occasionally and Repeatedly Vaccinated Healthcare Workers: A Five-Year Study (2009-2014)
Authors: Amdam Håkon , Madsen Anders , Zhou Fan , Bansal Amit , Trieu Mai-Chi , Cox Rebecca Jane 
Published: December 2021

BackgroundIn 2009, a novel influenza A/H1N1pdm09 emerged and caused a pandemic. This strain continued to circulate and was therefore included in the seasonal vaccines up to the 2016/2017-season. This provided a unique opportunity to study the long-term antibody responses to H1N1pdm09 in healthcare workers (HCW) with a different vaccination history.MethodsHCW at Haukeland University Hospital, Bergen, Norway were immunized with the AS03-adjuvanted H1N1pdm09 vaccine in 2009 (N=55) and divided into groups according to their vaccination history; one vaccination (N=10), two vaccinations (N=15), three vaccinations (N=5), four vaccinations (N=15) and five vaccinations (N=10). HCW are recommended for influenza vaccination to protect both themselves and their patients, but it is voluntary in Norway. Blood samples were collected pre- and at 21 days, 3, 6, and 12 months after each vaccination, or annually from 2010 HCW without vaccination. ELISA, haemagglutination inhibition (HI) and microneutralization (MN) assays were used to determine the antibody response.ResultsPandemic vaccination induced a significant increase in the H1N1-specific antibodies measured by ELISA, HI and MN. Seasonal vaccination boosted the antibody response, both in HCW with only the current vaccination and those with prior and current vaccination during 2010/11-2013/14. We observed a trend of increased antibody responses in HCW with only the current vaccination in 2013/14. A two- and three-year gap before vaccination in 2013/14 provided a more potent antibody response compared to annually vaccinated HCW.ConclusionsOur long term follow up study elucidates the antibody response in HCW with different vaccination histories. Our findings contribute to our understanding of the impact of repeated vaccination upon antibody responses.
Risk Factors for Acute Kidney Injury in Adult Patients With COVID-19: A Systematic Review and Meta-Analysis
Authors: Cai Xiaoyue , Wu Guiming , Zhang Jie , Yang Lichuan 
Published: December 2021

Background and Objective: Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly around the world. Studies found that the incidence of acute kidney injury (AKI) in COVID-19 patients was more than double the incidence of AKI in non-COVID-19 patients. Some findings confirmed that AKI is a strong independent risk factor for mortality in patients with COVID-19 and is associated with a three-fold increase in the odds of in-hospital mortality. However, little information is available about AKI in COVID-19 patients. This study aimed to analyse the risk factors for AKI in adult patients with COVID-19.Methods: A systematic literature search was conducted in PubMed, EMBASE, Web of Science, the Cochrane Library, CNKI, VIP and WanFang Data from 1 December 2019 to 30 January 2021. We extracted data from eligible studies to compare the effects of age, sex, chronic diseases and potential risk factors for AKI on the prognosis of adult patients with COVID-19.Results: In total, 38 studies with 42,779 patients were included in this analysis. The meta-analysis showed that male sex (OR = 1.37), older age (MD = 5.63), smoking (OR = 1.23), obesity (OR = 1.12), hypertension (OR=1.85), diabetes (OR=1.71), pneumopathy (OR = 1.36), cardiovascular disease (OR = 1.98), cancer (OR = 1.26), chronic kidney disease (CKD) (OR = 4.56), mechanical ventilation (OR = 8.61) and the use of vasopressors (OR = 8.33) were significant risk factors for AKI (P &lt; 0.05).Conclusions: AKI is a common and serious complication of COVID-19. Overall, male sex, age, smoking, obesity, hypertension, diabetes, pneumopathy, cardiovascular disease, cancer, CKD, mechanical ventilation and the use of vasopressors were independent risk factors for AKI in adult patients with COVID-19. Clinicians need to be aware of these risk factors to reduce the incidence of AKI.System Review Registration: PROSPERO, identifier [CRD42021282233].
CD200R Combined Neutrophil-Lymphocyte Ratio Predict 90-Day Mortality in HBV-Related Acute-On-Chronic Liver Failure
Authors: Li Yuxin , Kong Yaxian , Shi Ke , Huang Yunyi , Zhang Qun , Zhu Bingbing , Zeng Hui , Wang Xianbo 
Published: December 2021

Background:Survival of acute-on-chronic liver failure (ACLF) cannot be properly predicted based on clinical characteristics.Aims:This study aimed to develop a predictive model to evaluating the prognosis for hepatitis B virus-related ACLF (HBV-ACLF) based on specific laboratory and immune indicators.Methods:Baseline laboratory results were obtained and immune indicators were detected by flow cytometry. A predictive model, which estimates the prognosis at 90-day follow-up, was developed using data from a prospective study on 45 patients hospitalized of HBV-ACLF from June 2016 to April 2018 at the Beijing Ditan Hospital, Capital Medical University. The prognostic values of the predictive factors were determined by the area under the receiver operating characteristic (AUROC) curves.Results:Six factors exhibited statistical differences between the survival and non-survival groups: proportions of CD4+TN, CD4+TEM, CD8+TN, CD8+TEM, CD200R+CD4+T cells and neutrophil-lymphocyte ratio (NLR). CD200R combined with the NLR had an AUROC of 0.916, which was significantly higher than the AUROC values of CD200R+CD4+T cells (0.868), NLR (0.761), model for end-stage liver disease (MELD) (0.840), MELD-Na (0.870), Child-Turcotte-Pugh (CTP) (0.580), or chronic liver failure-consortium ACLF (CLIF-C ACLF) score(0.840). At the cut-off point of−3.87, matching the maximum Youden index determined by ROC analysis, the positive predictive and negative predictive values for the mortality were 0.86 and 0.97, respectively.Conclusions:The 90-day prediction model based on baseline levels of CD200R+CD4+T cells and NLR offers potential predictive value for the mortality of HBV-ACLF.