bluuebunny/crossref_metadata_2025_split huggingface dataset:
The New Role of Cardiac Imaging Following the ISCHEMIA Trial
Authors: Hanson Christopher A. , Patel Toral R. , Villines Todd C. 
Published: May 2021

Abstract
Purpose of review
This review is aimed at summarizing the recently published ISCHEMIA trial (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) and how its findings may impact cardiac imaging for stable ischemic heart disease (SIHD) moving forward.

Recent findings
The ISCHEMIA trial compared an initial invasive management strategy with goal of complete coronary revascularization versus an initial medical therapy strategy among stable patients with newly diagnosed moderate to severe myocardial ischemia on non-invasive testing. The trial results showed that an early invasive strategy did not reduce the incidence of major cardiovascular events over 3.2 years of follow-up as compared to optimal medical therapy in patients with SIHD.

Summary
The results of the landmark ISCHEMIA trial solidified the importance of guideline-directed medical therapy and have provided more evidence against the prevailing dogma that moderate to severe ischemia on traditional stress testing mandates coronary revascularization. This trial was not designed to compare different cardiac imaging and stress testing modalities for the assessment of coronary artery disease in patients undergoing their index evaluation for SIHD; however, its design, which included coronary computed tomographic angiography (CCTA) in most patients, and results have generated robust discussion regarding ways to improve non-invasive testing strategies in similar patient populations. We believe that increased utilization of CCTA to identify patients with and without high-risk SIHD, and advanced tests for ischemia, such as positron emission tomography and stress cardiac magnetic resonance imaging, when selected based on individual patient characteristics, may allow for improved decision-making and outcomes.
Polygenic Scores for Cognitive Abilities and Their Association with Different Aspects of General Intelligence—A Deep Phenotyping Approach
Authors: Genç Erhan , Schlüter Caroline , Fraenz Christoph , Arning Larissa , Metzen Dorothea , Nguyen Huu Phuc , Voelkle Manuel C. , Streit Fabian , Güntürkün Onur , Kumsta Robert , Ocklenburg Sebastian 
Published: May 2021

AbstractIntelligence is a highly polygenic trait and genome-wide association studies (GWAS) have identified thousands of DNA variants contributing with small effects. Polygenic scores (PGS) can aggregate those effects for trait prediction in independent samples. As large-scale light-phenotyping GWAS operationalized intelligence as performance in rather superficial tests, the question arises which intelligence facets are actually captured. We used deep-phenotyping to investigate the molecular determinants of individual differences in cognitive ability. We, therefore, studied the association between PGS of intelligence (IQ-PGS), cognitive performance (CP-PGS), and educational attainment (EA-PGS) with a wide range of intelligence facets in a sample of 557 healthy adults. IQ-PGS, CP-PGS, and EA-PGS had the highest incrementalR2s for general (2.71%; 4.27%; 2.06%), verbal (3.30%; 4.64%; 1.61%), and numerical intelligence (3.06%; 3.24%; 1.26%) and the weakest for non-verbal intelligence (0.89%; 1.47%; 0.70%) and memory (0.80%; 1.06%; 0.67%). These results indicate that PGS derived from light-phenotyping GWAS do not reflect different facets of intelligence equally well, and thus should not be interpreted as genetic indicators of intelligence per se. The findings refine our understanding of how PGS are related to other traits or life outcomes.
Development of a hardware-in-the-loop demonstrator for the validation of fault-tolerant control methods for a hybrid UAV
Authors: Prochazka F. , Krüger S. , Stomberg G. , Bauer M. 
Published: May 2021

AbstractMany aircraft are inherently over-actuated with regard to their input variables. This can be particularly advantageous in the context of unmanned aerial vehicles (UAV), where actuator functions can fail in critical situations. In such cases, the redundant actuators can be used to further fulfil the control strategies used and thus increase the operational safety. Within such an active fault-tolerant control system, a fault detection and isolation (FDI) module is required. To evaluate such safety–critical systems, hardware-in-the-loop simulations (HIL) are a necessary step prior to real flight tests. These simulations can verify the correct implementation of the flight controller on the target hardware as well as the real-time capability of the algorithms used. Particularly in the context of active fault-tolerant control, investigations concerning the robustness of the used FDI module with regard to real, noisy sensor signals, which can be generated by a HIL demonstrator, are of utter importance. This paper presents the development of a HIL demonstrator for the validation of fault-tolerant control methods for a hybrid UAV. This includes a detailed description of the demonstrator’s design, control and interfacing between the integrated subsystems. As an application example, a hybrid UAV model will be shortly presented, which, in addition to the primary aerodynamic control surfaces, can also use four lift rotors to control the aircraft during cruise and is therefore inherently over-actuated. Finally, a closed-loop real-time simulation of the UAV model on the HIL demonstrator is presented on the basis of the exemplary simulation of an actuator failure and subsequent reconfiguration by the fault-tolerant flight control law.
Shame in medical clerkship: “You just feel like dirt under someone’s shoe”
Authors: Whelan Beth , Hjörleifsson Stefan , Schei Edvin 
Published: May 2021

Introduction This study explores how senior medical students’ experience and react to shame during clinical placements by asking them to reflect on (1) manifestations of shame experiences, (2) situations and social interactions that give rise to shame, and (3) perceived effects of shame on learning and professional identity development.
Methods In this interpretive study, the authors recruited 16 senior medical students from two classes at a Norwegian medical school. In three focus group interviews, participants were invited to reflect on their experiences of shame. The data were analyzed using systematic text condensation, producing rich descriptions about students’ shame experiences.
Results All participants had a range of shame experiences, with strong emotional, physical, and cognitive reactions. Shame was triggered by a range of clinician behaviours interpreted as disinterest, disrespect, humiliation, or breaches of professionalism. Shame during clinical training caused loss of confidence and motivation, worries about professional competence, lack of engagement in learning, and distancing from shame-associated specialties. No positive effects of shame were reported.
Discussion Shame reactions in medical students were triggered by clinician behaviour that left students feeling unwanted, rejected, or burdensome, and by humiliating teaching situations. Shame had deleterious effects on motivation, learning, and professional identity development. This study has implications for learners, educators, and clinicians, and it may contribute to increased understanding of the importance of supportive learning environments and supervisors’ social skills within the context of medical education.
An intuitionistic fuzzy entropy approach for supplier selection
Authors: Rahimi Mohamadtaghi , Kumar Pranesh , Moomivand Behzad , Yari Gholamhosein 
Published: May 2021

AbstractDue to apparent flexibility of Intuitionistic Fuzzy Set (IFS) concepts in dealing with the imprecision or uncertainty, these are proving to be quite useful in many application areas for a more human consistent reasoning under imperfectly defined facts and imprecise knowledge. In this paper, we apply notions of entropy and intuitionistic fuzzy sets to present a new fuzzy decision-making approach called intuitionistic fuzzy entropy measure for selection and ranking the suppliers with respect to the attributes. An entropy-based model is formulated and applied to a real case study aiming to examine the rankings of suppliers. Furthermore, the weights for each alternative, with respect to the criteria, are calculated using intuitionistic fuzzy entropy measure. The supplier with the highest weight is selected as the best alternative. This proposed model helps the decision-makers in better understanding of the weight of each criterion without relying on the mere expertise.
Artificial Intelligence-Based Optimization of Industrial Membrane Processes
Authors: Gaudio Maria Teresa , Coppola Gerardo , Zangari Lorenzo , Curcio Stefano , Greco Sergio , Chakraborty Sudip 
Published: May 2021

AbstractArtificial intelligence (AI) is gaining acceptance for modern control systems in various applications in daily life including the Chemical process industry. Above all, application of AI is increasing in the field of membrane-based treatment where it shows great potential until now. Membrane separations are generally recognized as energy-efficient processes. In particular, membrane desalination, forward osmosis, energy generation, and biomass treatment have shown substantial potential in modern industries, such as wastewater treatment, pharmaceuticals, petrochemicals, and natural products. All these industries consume more than 20% of total energy consumption in the world. Moreover, the laboratory research outcomes illuminate the way to better membrane design and development, including advanced process control and optimization. The membrane processes with existing technologies for a sustainable environment could be integrated with the AI model. This review summarizes several membrane-based water treatment designs and plant performances where artificial intelligence is being used to minimize waste generation and lead to cleaner production.
Experimental Setup for the Investigation of Reproducibility of Novel Tool Changing Systems in Nanofabrication Machines
Authors: Weigert Florian , Hebenstreit Roman , Füßl Roland , Theska René 
Published: May 2021

AbstractNanomeasuring machines developed at the Technische Universität Ilmenau enable three-dimensional measurements and manufacturing processes with the lowest uncertainties. Due to the requirements for these processes, a highly reproducible and long-term stable tool changing system is needed. For this purpose, kinematically determined couplings are widely used. The state-of-the-art investigations on those are not sufficient for the highest demands on the reproducibility required for this application. A theoretical determination of the reproducibility based on analytical or numerical methods is possible, however not in the desired nanometer range. Due to this, a measurement setup for the determination of the reproducibility in five degrees of freedom with nanometer uncertainty was developed. First, potential measuring devices are systematically examined and measurement principles were developed out of this. A three-dimensional vector-based uncertainty analysis is performed to prove the feasibility of the measurement principle and provides a basis for further design. As a result, a translatory measurement uncertainty of 10 nm and a rotatory uncertainty of 11 nrad can be reached. Afterwards, the measurement setup is designed, focusing on the metrological frame and the lift-off device. The developed setup exceeds the uncertainties of the measurement setups presented in the state-of-the-art by an order of magnitude, allowing new in-depth investigations of the reproducibility of kinematic couplings.
Changes in Sexual Fantasy and Solitary Sexual Practice During Social Lockdown Among Young Adults in the UK
Authors: Cascalheira Cory J. , McCormack Mark , Portch Emma , Wignall Liam 
Published: May 2021

Abstract

Introduction
Pandemic-related social lockdown limited many sexual behaviors, but to date, no study has examined the perceived impact of social lockdown due to COVID-19 on sexual fantasy and solitary sexual behavior.

Aims
The present study sought to examine the perceived impact of social lockdown on sexual fantasy and solitary sexual behavior among UK young adults in various living situations.

Methods
A convenience sample of 565 adults aged 18–32 and living in the UK completed anonymous, web-based, study-specific questionnaires between May 14 and 18, 2020, 7 weeks after social lockdown was initiated. Mixed-method analyses were conducted.

Main Outcome Measures
The study presents qualitative and quantitative data. Criterion variables were measured dichotomously as increases (vs no change) in sexual fantasy and increases (vs no change) in pornography consumption. Predictor variables were living arrangement, relationship status, and postlockdown changes in masturbation and pornography consumption.

Results
Of all, 34.3% engaged in more sexual fantasizing during lockdown; women were more likely than men to report this increase. Living context and relationship status were predictors of increased fantasizing. Of all, 30.44% reported an increase in at least one solitary sexual practice. This increase was associated with an increase in sexual fantasizing and also with increased pornography consumption. Nineteen percent of participants reported an increase in pornography use, with men being more likely than women to report this increase. Participants mostly attributed their increases to boredom, increased free time, and replacing partnered sex.

Conclusion
Shifts in sexual fantasizing and solitary sexual practices were predicted by living arrangements, relationship status, and gender. The present findings suggest that the assessment of sexual fantasy and solitary sexual activities may benefit patients presenting with pandemic-related stress. Although mostly exploratory, significant changes in sexual fantasy and solitary sexual practices were observed. A cross-sectional design, convenience sampling, and study-specific measures are limitations.
Whole-Genome Study of a Multigenerational Family with Essential Tremor
Authors: Zhang Ming , Rohani Mohammad , Montazer Haghighi Mahdi , Sato Christine , Rogaeva Ekaterina , Fasano Alfonso 
Published: May 2021

ABSTRACT:Background:Essential tremor (ET) is a common movement disorder with ˜5% prevalence in individuals above the age of 65, but in rare cases, it arises during childhood. Growing evidence suggests the role of cerebellum in the disease mechanism. ET is highly heritable, however, poor replication of risk loci point to its significant heterogeneity. Thus, it is important to genetically investigate kindreds with a strong aggregation of ET.Methods:We conducted a clinical and whole-genome investigation of a large Caucasian Canadian family, in which six out of eight patients are affected by childhood-onset ET in four consecutive generations. Eight family members were available for study, including three patients affected by ET. Whole-genome sequencing (WGS) was conducted for the four most informative individuals, followed by Sanger sequencing in the entire kindred.Results:We searched for rare variants absent in the eldest unaffected individual, but present in the patients (two siblings and their third-degree relative). Our stringent whole-genome filtering approach revealed a rare heterozygous p. Arg90Gln substitution in TCP10L (rs151233771) in all three investigated patients. Sanger sequencing confirmed the p. Arg90Gln variant and revealed its absence in the rest of the family members.Conclusions:Whole-genome data of the family with ET resulted in a single candidate gene mapped to 21q22.11 locus (TCP10L) with the highest brain expression in cerebellum. Our study encourages future replication studies to validate the genetic link between TCP10L and ET, and suggests the p. Arg90Gln variant for functional investigation.
Development of novel home-based tampon sampling for endometrial cancer: findings from community-based focus groups with Black and White women
Authors: Ridgeway Jennifer L. , Albertie Monica L. , Williams Shantel , Pantoja Elizabeth , Stephenson Noreen , Pacheco-Spann Laura , Ball Colleen T. , Radecki Breitkopf Carmen , Bakkum-Gamez Jamie N. , Chase Lori , DeStephano Christopher C. , Sherman Mark E. 
Published: May 2021

Abstract
Novel endometrial cancer (EC) early-detection approaches may reduce racial disparities in mortality. We conducted six community-based focus groups with White and Black women (N = 57 participants) in February-March 2020 to explore acceptability of a home-based tampon sampling approach for EC. Participants also completed a survey. Data were analyzed using qualitative content analysis. Awareness of EC and risk factors was low. Acceptability regarding home sampling was high, but participants expressed concerns about instruction complexity and potential risks. Black women reported lower comfort with tampons. Increasing EC awareness, self-efficacy, and familiarization with tampons would advance prospects for at-home sample collection for EC testing.
Do We Deserve Credit for Everything We Understand?
Authors: Malfatti Federica Isabella 
Published: May 2021

AbstractIt is widely acknowledged in the literature in social epistemology that knowledge has a social dimension: we are epistemically dependent upon one another for most of what we know. Our knowledge can be, and very often is, grounded on the epistemic achievement of somebody else. But what about epistemic aims other than knowledge? What about understanding? Prominent authors argue that understanding is not social in the same way in which knowledge is. Others can put us in the position to understand, but when we understand something, this accomplishment is to be credited mainly if not entirely to us, as it is due to the successful exercise of our own cognitive abilities. In this paper, I show that the social dimension of understanding closely resembles the social dimension of knowledge. I distinguish between three different ways in which a subject can depend upon another subject for (either the acquisition or the possession of) a certain epistemic good. I then argue that all these kinds of epistemic dependence apply to knowledge and understanding alike. If I am right, understanding is not (always) an achievement to be (mainly) credited to the single epistemic agent who understands.
The Genetically Modified Organisms’ Regime: A Playground for Multi-Level Administration and a Nightmare for Effective Judicial Protection?
Authors: Lanceiro Rui , Eliantonio Mariolina 
Published: May 2021

AbstractThe European Union has a comprehensive legal framework in place for the authorization, traceability, and labelling of genetically modified organisms, the aim of which is to create a unified market while simultaneously ensuring that the placing on the market of the products concerned will not pose a risk to human or animal health or to the environment. This framework sets out complex, multi-level procedures which entail the cooperation and sharing of information between various national and European authorities. Filling a gap in the literature, this contribution focuses on the challenges to the system of judicial accountability that emerge in this particular system of multi-level administration. This Article shows that the problems posed by composite procedures in terms of access to justice and effective judicial protection can possibly be solved in light of the current rules concerning the division of labor between national and European courts and the applicable case law of the Court of Justice. As this Article will show, many more unsolved issues arise instead with respect to the compliance with the requirements of access to justice provided by the Aarhus Convention.
Ethnicity and Estate: The Galician Jacquerie and the Rwandan Genocide Compared
Authors: Kamusella Tomasz 
Published: May 2021

AbstractIn national historiography, estate (social) divisions are typically disregarded in favor of supposedly shared ethnicity, which is proposed to have united a given nation for centuries. Hence, the Polish national historiography is unable to account for the Galician Jacquerie (1846), when serfs were killing nobles, despite their (retroactively) assumed shared Polish ethnicity. On the other hand, the 1994 mass massacre of the Tutsis by Hutus is recognized as the Rwandan Genocide, though both groups share the same language, culture, and religion—or what is usually understood as ethnicity. What has sundered the Tutsis and the Hutus is the estate-like socioeconomic difference, or a memory thereof. It appears that under certain conditions estate (social, class) difference may become an ethnic boundary. In the case of the aforementioned jacquerie, the estate difference made the serfs and the nobles into two different de facto ethnic groups. Similarly, in Rwanda, estate (social) difference is implicitly posed as ethnicity, thus making the Hutus and the Tutsis into separate ethnic groups. However, the official definition of genocide as adopted by the United Nations explicitly excludes social groups (for instance, estates) from its purview, leading to terminological paradoxes.
On the low-dimensional cohomology groups of the IA-automorphism group of the free group of rank three
Authors: Satoh Takao 
Published: May 2021

AbstractIn this paper, we study the structure of the rational cohomology groups of the IA-automorphism group$\mathrm {IA}_3$of the free group of rank three by using combinatorial group theory and representation theory. In particular, we detect a nontrivial irreducible component in the second cohomology group of$\mathrm {IA}_3$, which is not contained in the image of the cup product map of the first cohomology groups. We also show that the triple cup product of the first cohomology groups is trivial. As a corollary, we obtain that the fourth term of the lower central series of$\mathrm {IA}_3$has finite index in that of the Andreadakis–Johnson filtration of$\mathrm {IA}_3$.
Soybean yield in integrated crop–livestock system in comparison to soybean–maize succession system
Authors: Muniz Mariane Porto , Costa Kátia Aparecida de Pinho , Severiano Eduardo da Costa , Bilego Ubirajara Oliveira , Almeida Dieimisson Paulo , Furtini Neto Antonio Eduardo , Vilela Lourival , Lana Marcos Alberto , Leandro Wilson Mozena , Dias Mariana Borges de Castro 
Published: May 2021

AbstractAmong integrated crop–livestock systems, forage succession is an advantageous strategy for the use of pasture to feed cattle in periods of low rainfall, as well as for the generation of biomass for the no-till system for the next crop. Different species have different abilities to accumulate nutrients in their biomass, which are then released into the soil through the decomposition of crop residues. This study aimed to evaluate soybean yield in an integrated crop–livestock system in comparison to soybean–maize succession system through the production, decomposition and nutrient accumulation in the biomass. The experiment had a randomized block design with four replicates. The treatments were three cropping systems: integrated crop–livestock with Paiaguas palisadegrass (Brachiaria brizantha cv. BRS Paiaguas), integrated crop–livestock with Tamani guinea grass (Panicum maximum cv. BRS Tamani) and maize grown in succession to soybean. The results showed that the use of the integrated crop–livestock system in the form of forage succession provided greater soil cover and nutrient cycling as a result of the better utilization of the animal's excreta, than the cropping of maize in succession and resulted in higher soybean productivity, thus contributing to agricultural sustainability. Paiaguas palisadegrass and Tamani guinea grass showed a C:N ratio greater than 30:1, indicating slow decomposition of plant residues. The forages accumulated amounts of nutrients in their biomass that met the soybean demand, resulting in higher grain yield.