bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of concentric and eccentric porous layer on forced convection heat transfer and fluid flow around a solid cylinder
Authors: Alinezhad Alireza , Goharrizi Ataallah Soltani , Kamyabi Ataallah 
Published: December 2021

Abstract
In this paper, heat transfer and fluid flow around a solid cylinder wrapped with a porous layer in the channel were studied numerically by computational fluid dynamics (CFD). The homogeneous concentric and eccentric porous medium round a rigid, solid cylinder are supposed at local thermal equilibrium. The transport phenomena within the porous layer, volume averaged equations were employed, however the conservation laws of mass, momentum and energy were applied in the channel. This current numerical analysis, the effects of eccentricity ( ), the variable diameter of porous layer (d=0.07,0.08,0.09), permeability, as well as the different Reynolds number and Darcy number on the heat transfer parameters and fluid flow was investigated. The main purpose of this study is analyzed and compared the heat flux of concentric and eccentric porous layer in Reynolds number range of 1 to 40 and Darcy numbers of to . It is found that with the decline of Darcy number, the vortex length is increased behind the solid cylinder surface. In addition, the heat flux rate of the cylinder is raised with the increase of Reynolds number. Finally, The results have demonstrated that with raising Reynolds and Darcy numbers, the increase of the average Nusselt numbers in the eccentric porous layer is higher than the concentric porous layer.
Prevalence of Anemia and Its Association with Handgrip Strength in Indonesian Elderly Population: A Cross-Sectional Study Using Indonesian Family Life Survey Data Year 2014-2015
Authors: Sutandyo Noorwati , Rinaldi Ikhwan , Sari Nina Kemala , Winston Kevin 
Published: December 2021

Abstract
Aim

This study aimed to elucidate the prevalence of anemia in Indonesian elderly population aged ≥60 years old and to analyze its association with handgrip strength in the elderly.
Method

This was a cross-sectional study using data from Indonesian Family Life Survey-5 (IFLS-5). All participants aged ≥60 years old were included in this study. Exclusion criteria were: (1) respondents who refused to take health measurements (hemoglobin level, handgrip strength, weight, stature, and waist circumference); (2) respondents with incomplete or missing data; (3) respondents with history of stroke; and (4) respondents with history of pain, swelling, inflammation, injury, and surgery on one or both hands within the last 6 months. The dependent variable for this study was handgrip strength. The independent variables were hemoglobin level, gender, age, body mass index (BMI), waist circumference, smoking history, comorbidities, and current use of drug therapies. Statistical analyses included correlation, bivariable, and multivariable analyses.
Result

A total of 3192 individuals were selected for analysis. Overall, 38.8% of participants aged ≥60 years had anemia based on definition of anemia by WHO. There was a positive correlation between hemoglobin level and handgrip strength in Indonesian elderly population (r: 0.349; p value: 0.000). Multivariable analysis showed that anemia was significantly associated with weak handgrip strength (OR: 1.557; 95% CI: 1.314-1.846; p value: 0.000). This association was stronger for males and elderly aged ≥80 years old.
Conclusion

Based on the results, anemia was associated with weak handgrip strength in Indonesian elderly population and it is more pronounced in males and elderly aged ≥80 years old.
NUPR1 Promotes the Proliferation and Migration of Breast Cancer Cells by Activating TFE3 Transcription to Induce Autophagy
Authors: Xiao Heng , Long Jing , Chen Xiang , Tan Mi-Duo 
Published: December 2021

Abstract
Background: Breast cancer is a commonplace carcinoma in females. Recurrence and metastasis are the main problems affecting the survival rate of patients. The fundamental reason is the lack of understanding of the mechanism of breast cancer metastasis. This study aims to deliberate on the efficaciousness of Nuclear protein 1 (NUPR1)-mediated autophagy on breast cancer metastasis.Methods: The proliferation, migration and invasion ability of breast cancer cells were appraised by CCK-8, wound healing, and colony formation, as well as transwell assay. The relationship between NUPR1 and Translocation factor E3 (TFE3) was appraised by qPCR, western blot and ChIP. Migration-invasion-related proteins and autophagy-related proteins were appraised by western blot. The effects of NUPR1 on malignancy formation and metastasis were studied in vivo.Results: NUPR1 was upregulated in breast cancer cells and tissues. NUPR1 knockdown restrained the proliferation, migration and invasion of ZR-75-30 cells. Moreover, NUPR1 knockdown restrained malignancy formation and metastasis in vivo. Mechanically, NUPR1 promoted autophagy through activation of TFE3 transcription, thereby regulating the process of breast cancer metastasis.Conclusion: This paper elucidates the molecular mechanism of NUPR1 promoting breast cancer metastasis by activating autophagy through TFE3 signaling pathway, which provided biological basis for intervention of blocking distant metastasis.
A Novelty Energy Storage Algorithm for High Speed Trains: Economical and Energy Saving Evaluation
Authors: Sertsöz Mi̇ne 
Published: December 2021

Abstract
Increasing the utilization rate of regenerative braking energy in rail systems is one of the ongoing applications increasing in significance in recent years. This study develops a novelty algorithm within the scope of this objective and provides the calculation of the regenerative braking energy recovery rate and then making a decision for storage or back to grid of this energy. Afterwards, the regenerative braking energy was calculated with the help of this algorithm for Eskisehir-Ankara and Ankara-Eskisehir trips in two different passengers (load) scenarios, using the YHT 65000 high-speed train, which was chosen as a case study. Then, with a decision maker added to this classical regenerative braking energy algorithm, it will be decided whether this energy will be stored or forward back into the grid for the purpose of providing non-harmonic energy to the grid.
Detecting Damage Building Using Real-Time Crowdsourced Images And Transfer Learning
Authors: Chachra Gaurav , Kong Qingkai , Huang Jim , Korlakunta Srujay , Grannen Jennifer , Robson Alexander , Allen Richard 
Published: December 2021

Abstract
After significant earthquakes, we can see images posted on social media platforms by individuals and media agencies owing to the mass usage of smartphones these days. These images can be utilized to provide information about the shaking damage in the earthquake region both to the public and research community, and potentially to guide rescue work. This paper presents an automated way to extract the damaged building images after earthquakes from social media platforms such as Twitter and thus identify the particular user posts containing such images. Using transfer learning and ~6500 manually labelled images, we trained a deep learning model to recognize images with damaged buildings in the scene. The trained model achieved good performance when tested on newly acquired images of earthquakes at different locations and ran in near real-time on Twitter feed after the 2020 M7.0 earthquake in Turkey. Furthermore, to better understand how the model makes decisions, we also implemented the Grad-CAM method to visualize the important locations on the images that facilitate the decision.
Non-Native Herbivores Promote Plant Invasions Away From Mountain Roads in the Andes
Authors: Aschero Valeria , Barros Agustina , Bonjour Lorena , Mazzolari Ana , Sosa Martín Pérez , Cuevas Fernanda , Novillo Agustina , Álvarez María Alisa , Lillo Eduardo Fuentes , Pauchard Anibal , Lembrechts Jonas 
Published: December 2021

Abstract
While the role of environmental filters, usually described by elevation as proxy, and anthropogenic disturbance as drivers of non-native plant diversity and abundance in mountains have been extensively studied, the impact of herbivores are less explored. Livestock grazing can facilitate the introduction of non-native species by seed dispersal and reduce biotic resistance due to consumption and trampling of native plants, even in the highest protected areas in the Andes. We here explored the effects of elevation, livestock and distance to the road on non-native and native plant distributions. Our results confirm the largely negative relationship of non-native plant richness and cover with elevation, with a peak in richness and cover at low to intermediate elevations. Similarly, we show a strong decline in non-native richness with increasing distance to the road, especially at low elevations, accompanied by a strong negative effect of roads on native species richness. Most importantly, however, we show that the presence of non-native herbivores greatly increases the cover of non-native species away from the roadside, identifying herbivore disturbance as a potential catalyst of non-native plant invasion into natural vegetation of high-Andean protected areas. Our results confirm the often-shown role of disturbance as driver of plant invasions in mountains, yet highlight the interactive effects of disturbance by roads and herbivory: roads funnel non-native species towards higher elevations, while non-native herbivores can promote non-native plant success away from the roadside and into the natural vegetation. Hence, regulating soil and non-native herbivory disturbance is important for minimizing plant invasions at high elevation in the Arid Andes.
On the Hot Isostatic Pressing of Inconel 625 Structures built using Laser Powder Bed Fusion at Higher Layer Thickness
Authors: Nayak Saurav Kumar , Jinoop Arackal Narayanan , Paul Christ Prakash , Kumar Vesangi Anil , Subburaj Dineshraj , Singh Rashmi , Bindra Kushvinder Singh 
Published: December 2021

Abstract
This paper reports the effect of Hot Isostatic Pressing (HIPing) on the porosity, microstructure and mechanical properties of Laser Powder Bed Fusion (LPBF) IN625 structures built at a higher layer thickness of 100 µm. It is observed that the process-induced pores/voids of volume fraction (Vf) 0.43% in as-built IN625 structures are reduced significantly to ~ 0.01% after HIPing treatment. The microstructure is changed from fine columnar dendrites to coarse equiaxed dendrites. The microstructural analysis of as-built structures reveals the presence of cellular/ dendritic growth along with elemental segregation of Nb, Si and C and precipitation of Nb-rich carbides. Whereas, coarse recrystallized microstructure along with elemental segregation of Si and precipitation of Nb, Mo and Cr rich carbides are observed in Hot Isostatic Pressed (HIPed) samples. HIPed structures exhibit lower tensile s trength, higher ductility, and lower anisotropy as compared to LPBF built structures. There is a reduction in the Vickers micro-hardness of IN625 samples after HIPing and the values are observed to be similar to their conventional counterparts. Further, an increase in the energy storage capacity of the material is observed after HIPing treatment through Automated Ball Indentation (ABI®) studies. The study paves a way to develop ~100% dense, defect-free and isotropic engineering components using LPBF.
Lump Solutions, Multi Lump Solutions and More Soliton Solutions of a Novel (2+1)-dimensional Nonlinear Evolution Equation
Authors: Ma Hongcai , Yue Shupan , Gao Yidan , Deng Aiping 
Published: December 2021

Abstract
Exact solutions of a new (2+1)-dimensional nonlinear evolution equation are studied. Through the Hirota bilinear method, the test function method and the improved tanh-coth and tah-cot method, with the assisstance of symbolic operations, one can obtain the lump solutions, multi lump solutions and more soliton solutions. Finally, by determining different parameters, we draw the three-dimensional plots and density plots at different times.
Bilderbuch als Klangmedium
Authors: Oberhaus Lars , Oetken Mareile 
Published: December 2021

Artikelbeginn:[English title and abstract below]
Musik und Klang können auf unterschiedliche Weise Eingang in ein Bilderbuch finden. Aus methodischer Sicht lassen sich auf der einen Seite außermusikalische Inhalte (v. a. Texte und Bilder) musikalisch darstellen (Verklanglichung, Vertonung), und auf der anderen Seite besteht die Möglichkeit, Musik in andere Medien zu transformieren (Bild und Visualisierung, Bewegung und Verkörperung, Text und Versprachlichung). Diese Interdependenzen finden sich auch in Gattungen und Kompositionstechniken, wie z. B. Oper und Programmmusik, in denen sich Handlung, Text und Musik wechselseitig beeinflussen und überlagern.

The Picture Book as a Sound MediumAesthetic, Scientific and Artistic Perspectives
This article is an overview of the relevance of sound and music in picturebooks. Various possible relationships between images, words and sounds are shown, and different formats and historical developments are discussed. A focus is placed on the dimensions of the narrative context and the relevance of different types of media. Traditionally, the relation between music, words and images included setting picturebooks to music. In the last few years, electronic book media such as e-books, enhanced books and picturebook apps, which offer a combined, multimedial listening, reading and viewing experience, present new perspectives for intermedial picturebook research. The article details strategies for analysing the picturebook as a sound medium, using methods and concepts from film analysis, aesthetic transformation and the concept of aurality to show how the medium of sound is an open, ambiguous aesthetic quality that enriches picturebooks with its contingent possibilities for symbolic representation.
Fifteen years of experience in plastic liquor fistulas using high-intensity laser radiation
Authors: Korkmazov M. Yu. , Angelovich M. S. , Lengina M. A. , Yastremsky A. P. 
Published: December 2021

Introduction. The need to close liquor fistulas as early as possible is associated with a high risk of intracranial complications. Certain difficulties in closing bone defects are due to the variability of the exact localization of the fistulous canal, the choice of the surgical approach, and the reliability of the plastic material. The literature describes various methods for eliminating basal liquorrhea, however, the advantage of none of them has not been proven, which determines the relevance of the search for new methods.Objective. Based on the analysis of long-term results, to study the efficiency of plastic closure of cerebrospinal fluid fistulas using high-intensity laser radiation.Materials and methods. An analysis of 15 years of experience in studying the effectiveness of plastic closure of cerebrospinal fluid fistulas in 126 operated patients with basal liquorrhea was carried out. The duration of the disease ranged from 2 months to 1.5 years. The main group consisted of 94 patients who underwent plastic closure of CSF fistulas using high-intensity laser radiation with a wavelength of 0.97 pm and a power of 2.5-3.5 W. The control group consisted of 32 patients who did not receive coherent laser radiation. In addition to the generally accepted methods of postoperative management, low-frequency ultrasonic cavitation irrigation of the operated cavities was used to accelerate the reparative processes in all patients.Results and discussion. The average follow-up period after surgery was over 13 years. When comparing the results of treatment, the main criterion for evaluating the effectiveness of the operation was the frequency of relapses. In 15 (12.3%) cases, a relapse was noted, of which 5 (3.71%) were patients in the main group and in 10 (8.32%) patients in the control group, who were closed by repeated surgeryConclusion. The clinical features of the basal liquorrhea include the variability in the localization of the fistulous canals, certain difficulties in their detection, a wide variety of plastic closure methods, and a high percentage of relapses. A prospective uncontrolled study has shown that this method of CSF fistula plasty using improves the efficiency of surgical treatment.
Centro de Salud I-3, Chincha- Peru
Authors: Nery Figueiredo André , Estrada Rivas Lesli , Moscoso Espinoza Wilfredo 
Published: December 2021

A temática projetual analisada neste artigo se trata da proposta ganhadora do Primeiro Lugar na XI Bienal de Arquitetura Bioclimática José Miguel Aroztegui.
Nessa perspectiva, o curso em Arquiteturae Urbanismo Ambiental da Universidade Científica do Sul, em Lima, Peru, já está trabalhando com seus alunos em estratégias transversais para pesquisas de projetos vinculadas a uma abordagem ambiental, de maneira aplicada a seus vários ateliês de projeto, e, por ocasião deste concurso internacional, foram propostos especificamente aos alunos de Ateliê de Pesquisa e Projeto VI, onde são normalmente desenvolvidas soluções arquitetônicas com o tema saúde de média complexidade, o desafio de propor propostas para o estabelecimento de Saúde do tipo I-3, que de acordo com os critérios de uso, demanda e serviços fornecidos, se assemelha à Unidade Básica de Saúde (UBS), um produto arquitetural referencial esperado pela comissão do Concurso.
O local do estudo está localizado na cidade de Chincha, província de Ica, Peru, na costa do Oceano Pacífico, com um importante desenvolvimento econômico nos últimos anos devido ao agronegócio e ao setor de serviços, e carece de centros de saúde próximos no nível da comunidade.
A solução arquitetônica atende a essa necessidade direta da comunidade, com um estudo sólido e estruturado de estratégias bioclimáticas aplicadas na perspectiva de um projeto biofílico, como alternativa e solução que se baseia desde o início em um conceito de energia sustentável.
Can We Use mTOR Inhibitors for COVID-19 Therapy?
Authors: Aneva Ina Y. , Kashani Hamid Reza Khayat , Habtemariam Solomon , Banach Maciej , Sil Parames C. , Sarkar Kasturi , Sahebnasagh Adeleh , Kamal Mohammad Amjad , Khayatkashani Maryam 
Published: December 2021

:
Infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) provokes
acute inflammation due to extensive replication of the virus in the epithelial cells of the upper
and lower respiratory system.
The mammalian target of rapamycin (mTOR) is a l signalling protein with critical functions in cell
growth, metabolism, and proliferation. It is known for its regulatory functions in protein synthesis and
angiogenesis cascades. The structure of mTOR consists of two distinct complexes (mTORC1 and
mTORC2) with diverse functions at different levels of the signalling pathway. By activating mRNA
translation, the mTORC1 plays a key role in regulating protein synthesis and cellular growth. On the
other hand, the functions of mTORC2 are mainly associated with cell proliferation and survival.
By using an appropriate inhibitor at the right time, mTOR modulation could provide immunosuppressive
opportunities as antirejection regimens in organ transplantation as well as in the treatment
of autoimmune diseases and solid tumours. The mTOR also has an important role in the inflammatory
process. Inhibitors of mTOR might indeed be promising agents in the treatment of viral infections.
They have further been successfully used in patients with severe influenza A/H1N1 pneumonia
and acute respiratory failure. The officially accepted mTOR inhibitors that have undergone
clinical testing are sirolimus, everolimus, temsirolimus, and tacrolimus. Thus, further studies on
mTOR inhibitors for SARS-CoV-2 infection or COVID-19 therapy are well merited.
In-Silico and In-Vitro Analysis of Human SOS1 Protein Causing Noonan
Syndrome - A Novel Approach to Explore the Molecular Pathways
Authors: Sigamani Vinoth , Rajasingh Sheeja , Gurusamy Narasimman , Panda Arunima , Rajasingh Johnson 
Published: December 2021

Aims:
Perform in-silico analysis of human SOS1 mutations to elucidate their pathogenic
role in Noonan syndrome (NS).

Background:
NS is an autosomal dominant genetic disorder caused by single nucleotide mutation
in PTPN11, SOS1, RAF1, and KRAS genes. NS is thought to affect approximately 1 in 1000. NS
patients suffer different pathogenic effects depending on the mutations they carry. Analysis of the
mutations would be a promising predictor in identifying the pathogenic effect of NS.

Methods:
We performed computational analysis of the SOS1 gene to identify the pathogenic nonsynonymous
single nucleotide polymorphisms (nsSNPs) th a t cause NS. SOS1 variants were retrieved
from the SNP database (dbSNP) and analyzed by in-silico tools I-Mutant, iPTREESTAB,
and MutPred to elucidate their structural and functional characteristics.

Results:
We found that 11 nsSNPs of SOS1 that were linked to NS. 3D modeling of the wild-type
and the 11 nsSNPs of SOS1 showed that SOS1 interacts with cardiac proteins GATA4, TNNT2,
and ACTN2. We also found that GRB2 and HRAS act as intermediate molecules between SOS1
and cardiac proteins. Our in-silico analysis findings were further validated using induced cardiomyocytes
(iCMCs) derived from NS patients carrying SOS1 gene variant c.1654A>G (NSiCMCs) and
compared to control human skin fibroblast-derived iCMCs (C-iCMCs). Our in vitro data confirmed
that the SOS1, GRB2 and HRAS gene expressions as well as the activated ERK protein, were significantly
decreased in NS-iCMCs when compared to C-iCMCs.

Conclusion:
This is the first in-silico and in vitro study demonstrating that 11 nsSNPs of SOS1
play deleterious pathogenic roles in causing NS.
Micronutrient Deficiency in Pulmonary Tuberculosis - Perspective on Hepatic
Drug Metabolism and Pharmacokinetic Variability of First-line Anti-
Tuberculosis Drugs: Special Reference to Fat-soluble Vitamins A, D, & E
and Nutri-epigenetics
Authors: Murugaiha Jeyakumar Shanmugam 
Published: December 2021

Abstract:
The liver plays a crucial role in endogenous metabolic activity and homeostasis of
macro and micronutrients. Further, it acts as a metabolic hub in mammals, where the ingested
food-derived nutrients and xenobiotics or drugs are metabolized for utilization and/or excretion
through its enzymatic and non-enzymatic machinery. Nutritional deficiency, one of the major
public health problems, is associated with global disease burden, including pulmonary tuberculosis
(PTB) caused by Mycobacterium tuberculosis (Mtb) infection. Though it is a curable and preventable
infectious disease, millions of people succumb to death, and people in numbers larger
than this are still suffering. This scenario is further complicated by the addition of new cases, disease
recurrence, and the emergence of drug-resistant, all of which contribute to the spread of this
epidemic. Though the manifestation of TB disease has multiple aetiologies, poor nutritional status
and sub-optimal therapeutic concentrations of first-line anti-TB drugs are considered as potential
contributors to its widespread prevalence. Among various factors, the pharmacokinetic variability
of anti-TB drugs is one of the main causes for sub-optimal therapeutic drug concentration in TB patients,
which is influenced by the host’s genetic make-up and nutritional status, besides several
others. However, the role of epigenetic changes in hepatic drug metabolic pathways and their transcript
levels is largely unexplored. Therefore, in this review, an attempt has been made to understand
the role of micronutrient deficiencies with special reference to fat-soluble vitamins, namely vitamin
A, D, & E in pulmonary TB, their possible impact on epigenetic changes on the drug-metabolizing
pathway genes, thus their expression levels and plausible influence on pharmacokinetic variability
of anti-TB drugs, besides discussing the limitations and emerging potential opportunities.
Eventually, this would help in developing the host-directed/personalized therapeutic strategies for
the elimination of pulmonary tuberculosis (PTB).