bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Lauterpachtian Affair: Security Exceptions as ‘Self-Judging Obligations’ in the Case Law of the International Court of Justice and Beyond
Authors: Milanov Momchil 
Published: August 2021

Abstract
Although Sir Hersch Lauterpacht never dealt with security exceptions during his time at the International Court of Justice (ICJ), his entire body of work formed the intellectual premise for the approach of the Court towards security exceptions and the way in which the ICJ manoeuvers in the larger debate on the relationship between law, politics and the proper discharge of the judicial function. The Lauterpachtian approach is understood as a particular attitude towards the judicial function in which the Court serves as an instrument for the protection of peace, as a guardian of the coherence and unity of the international legal system and as a driving force for the development of international law. However, in some other important elements of its reasoning, the Court seems to remain more Lauterpachtian in spirit than in letter. Despite these inconsistencies, the Court arguably exerted significant (albeit somehow uneven) influence over World Trade Organization panels and investment tribunals.
Kuril Ainu Zoonyms and Phytonyms in Pallas’s Zoographia and Flora Rossica
Authors: Alonso de la Fuente José Andrés 
Published: August 2021

Abstract
Close inspection of the Kuril Ainu vocabularies included in two of P.S. Pallas’s less-known publications reveal the existence of expressions which are apparently documented nowhere else. By attempting to identify their provenance, at least one new source comes into light, the general impression being, as one would rather expect, that there must be a multitude of them hidden in the travelogues and personal diaries of Russian explorers from the 18th century.
Slow Modes of Global Temperature Variability and Their Impact on Climate Sensitivity Estimates
Authors: Wills Robert C. J. , Armour Kyle C. , Battisti David S. , Proistosescu Cristian , Parsons Luke A. 
Published: August 2021

AbstractInternal climate variability confounds estimates of the climate response to forcing but offers an opportunity to examine the dynamics controlling Earth’s energy budget. This study analyzes the time-evolving impact of modes of low-frequency internal variability on global-mean surface temperature (GMST) and top-of-atmosphere (TOA) radiation in preindustrial control simulations from phase 6 of the Coupled Model Intercomparison Project (CMIP6). The results show that the slow modes of variability with the largest impact on decadal GMST anomalies are focused in high-latitude ocean regions, where they have a minimal impact on global TOA radiation. When these regions warm, positive shortwave cloud and sea ice–albedo feedbacks largely cancel the negative feedback of outgoing longwave radiation, resulting in a weak net radiative feedback. As a consequence of the weak net radiative feedback, less energy is required to sustain these long-lived temperature anomalies. In contrast to these weakly radiating high-latitude modes, El Niño–Southern Oscillation (ENSO) has a large impact on the global energy budget, such that it remains the dominant influence on global TOA radiation out to decadal and longer time scales, despite its primarily interannual time scale. These results show that on decadal and longer time scales, different processes control internal variability in GMST than control internal variability in global TOA radiation. The results are used to quantify the impact of low-frequency internal variability and ENSO on estimates of climate sensitivity from historical GMST and TOA-radiative-imbalance anomalies.
“Beyond Weather Regimes”: Descriptors Monitoring Atmospheric Centers of Action. A case study for Aotearoa New Zealand
Authors: Pohl Benjamin , Lorrey Andrew , Sturman Andrew , Quénol Hervé , Renwick James , Fauchereau Nicolas , Pergaud Julien 
Published: August 2021

AbstractThis paper introduces a set of descriptors applied to weather regimes, that allow for a detailed monitoring of the location and intensity of their atmospheric centers of action (e.g. troughs and ridges) and the gradients between them, when applicable. Descriptors are designed to document the effect of climate variability and change in modulating the character of daily weather regimes, rather than merely their occurrence statistics.As a case study, the methodology is applied to Aotearoa New Zealand (ANZ), using ERA5 ensemble reanalysis data for the period 1979-2019. Here, we analyze teleconnections between the regimes and their descriptors, and large-scale climate variability. Results show a significant modulation of centers of action by the phase of the Southern Annular Mode, with a strong relationship identified with the latitude of atmospheric ridges. Significant associations with El Niño Southern Oscillation are also identified. Modes of large-scale variability have a stronger influence on the regimes’ intrinsic features than their occurrence. This demonstrates the usefulness of such descriptors, which help understand the relationship between mid-latitude transient perturbations and large-scale modes of climate variability.In future research, this methodological framework will be applied to analyze (i) low-frequency changes in weather regimes under climate change, in line with the southward shift of storm tracks, and (ii) regional-scale effects on the climate of ANZ, resulting from interaction with its topography.
A Weak Temperature Gradient Framework to Quantify the Causes of Potential Intensity Variability in the Tropics
Authors: Rousseau-Rizzi Raphaël , Emanuel Kerry 
Published: August 2021

AbstractPotential intensity (PI) has been shown to have a linear sensitivity to sea surface temperature (SST) of about 8 m s−1 K−1, which is close to the sensitivity of PI in simulations subject to a weak temperature gradient (WTG) approximation. This suggests that most of the PI variance is associated with local rather than global SST variations. We verify that PI perturbations are approximately linear in SST, with slopes of 1.8 ± 0.2 m s−1 K−1 in radiative–convective equilibrium (RCE) and 9.1 ± 0.9 m s−1 K−1 in WTG. To do so, we simulate the sensitivity of both RCE and WTG states in a single-column model (SCM) perturbed by changing in turn CO2 concentration, aerosol concentrations, prescribed SST, and surface winds speeds. While PI is much more sensitive to SST in WTG than in RCE simulations, the SST itself is much less sensitive to radiative forcing in WTG than in RCE because of the absence of strong atmospheric response. Using these results, we develop a linear model, based on SST and midlevel saturation MSE perturbations, to partition SST and PI perturbations between local components occurring under a WTG constraint and global components that are representative of an RCE state. This model explains up to 95% of the variability of PI in reanalysis. The SCM-derived linear model coefficients are statistically indistinguishable from coefficients from a linear fit of reanalysis PI to SST and midlevel saturation MSE in most ocean basins. Our model shows that North Atlantic PI variations are explained almost entirely by local forcings in recent decades.
Factors Associated With Hearing Outcomes After Stapedotomy in Taiwanese Patients With Clinical Otosclerosis
Authors: Chen Pei-Hsin , Lin Kai-Nan , Lin Hsiu-Yin , Yu Rui-Bin , Liu Pi-Yun , Shih Wan-Ting , Chen Jeng-Wen 
Published: August 2021

Objective: To examine the clinical factors associated with the effectiveness of stapedotomy in improving hearing sensitivity in Taiwanese patients with otosclerosis. Methods: In this retrospective study, we reviewed the medical records of 31 patients (36 ears) with otosclerosis undergoing stapedotomy performed by a single surgeon. Preoperative and postoperative hearing results were analyzed to identify factors associated with hearing outcomes after stapedotomy in the Taiwanese population with clinical otosclerosis. Results: Compared with preoperative pure tone averages (PTAs), stapedotomy significantly improved postoperative air conduction (AC) thresholds ( P < .0001), bone conduction (BC) thresholds ( P = .025), and air-bone gaps (ABGs; P < .0001). Postoperative closure of ABGs less than 10 or 20 dB was achieved in 16 (44.4%) and 33 (91.7%) of 36 surgical ears. Improvement in postoperative AC thresholds and ABGs and the size of preoperative ABGs were significantly correlated (r = .650, P < .001 and r = .745, P < .001, respectively). Gender-stratified analysis indicated a stronger correlation between improvement in postoperative AC thresholds and preoperative ABGs in male patients than in female patients (r = .893, P < .001 and r = .476, P = .014, respectively), and in postoperative and preoperative ABGs (r = .933, P < .001 and r = .626, P < .001, respectively). With the more stringent criteria for surgical success, factors including age (≤50 years), type (conductive, BC ≤25 dB), and degree (PTA ≤55 dB) of preoperative hearing loss led to more favorable outcomes. Conclusions: We reported evidence supporting a potential gender difference on hearing outcomes after stapedotomy in Taiwanese patients with otosclerosis. Age, type, and degree of preoperative hearing loss may affect the surgical success rate.
Dysuria therapeutic agents as an independent prognostic factor for the primary recurrence of non-muscle invasive bladder cancer: a propensity score matching study
Authors: Kato Yoichiro , Ikarashi Daiki , Kikuchi Daichi , Takayama Misato , Kanzaki Seiko , Ito Akito , Tamura Daichi , Matsuura Tomohiko , Maekawa Shigekatsu , Kato Renpei , Kanehira Mitsugu , Takata Ryo , Sugimura Jun , Obara Wataru 
Published: August 2021

Objective To investigate if the use of therapeutic agents for dysuria is a risk factor for the primary recurrence of non-muscle invasive bladder cancer (NMIBC). Methods First, patients with NMIBC were divided into two groups: the non-recurrence group and the recurrence group. Patient characteristics were compared between both groups. The risk factors of recurrence that were statistically different between the two groups were identified by multivariate analysis. Second, we divided the patients into risk and non-risk groups, and differences in the recurrence-free survival (RFS) between the two groups were analyzed before and after propensity score matching (PSM). Results A total of 162 patients were included, with 84 patients in the non-recurrence group and 78 patients in the recurrence group. In the multivariate analysis, the intake of dysuria agents and bacillus Calmette–Guérin (BCG) therapy were independent factors. The RFS results in terms of the intake of dysuria agents were statistically significant before and after PSM analysis, but no factors were significantly different between the BCG and non-BCG groups after PSM. Conclusions Therapeutic agents for dysuria might be at an independent risk factor for NMIBC recurrence. This trial is registered with the UMIN Clinical Trials Registry under the number UMIN000036097 ( https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno = R000041122 ).
Doubtful use of placebo following placebo in recent controlled trials of lasmiditan and ubrogepant for the treatment of migraine attacks
Authors: Tfelt-Hansen Peer , Jørgensen Karsten , Diener Hans-Christoph 
Published: August 2021

Purpose In four large controlled trials with lasmiditan and ubrogepant placebo was administered in the first step to demonstrate an effect on migraine attack. In the same trials the investigators also asked the question: is a second dose of the drug effective in non-responders to the first dose? In this phase patients who received placebo in the first phase of the trial again after 2 hours received another dose of placebo. Conclusion To be ethical, clinical research requires balancing rigorous science with the protection of human subjects; and it is, in our view, questionable whether placebo was used with “scientific rigor” in the second step of these trials, and this design is not recommended.
CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine
Authors: Christensen Sarah L , Rasmussen Rikke H , Ernstsen Charlotte , La Cour Sanne , David Arthur , Chaker Jade , Haanes Kristian A , Christensen Søren T , Olesen Jes , Kristensen David M 
Published: August 2021

Background Knowledge of exact signalling events during migraine attacks is lacking. Various substances are known to trigger migraine attacks in patients and calcitonin gene-related peptide antagonising drugs are effective against migraine pain. Here, we investigated the signalling pathways involved in three different mouse models of provoked migraine and relate them to calcitonin gene-related peptide and other migraine-relevant targets. Methods In vivo mouse models of glyceryl trinitrate-, cilostazol- and levcromakalim-induced migraine were applied utilising tactile sensitivity to von Frey filaments as measuring readout. Signalling pathways involved in the three models were dissected by use of specific knockout mice and chemical inhibitors. In vivo results were supported by ex vivo wire myograph experiments measuring arterial dilatory responses and ex vivo calcitonin gene-related peptide release from trigeminal ganglion and trigeminal nucleus caudalis from mice. Results Glyceryl trinitrate-induced hypersensitivity was dependent on both prostaglandins and transient receptor potential cation channel, subfamily A, member 1, whereas cilostazol- and levcromakalim-induced hypersensitivity were independent of both. All three migraine triggers activated calcitonin gene-related peptide signalling, as both receptor antagonism and antibody neutralisation of calcitonin gene-related peptide were effective inhibitors of hypersensitivity in all three models. Stimulation of trigeminal ganglia and brain stem tissue samples with cilostazol and levcromakalim did not result in release of calcitonin gene-related peptide, and vasodilation following levcromakalim stimulation was independent of CGRP receptor antagonism. Conclusion The mouse models of glyceryl trinitrate-, cilostazol- and levcromakalim- induced migraine all involve calcitonin gene-related peptide signalling in a complex interplay between different cell/tissue types. These models are useful in the study of migraine mechanisms.
Revitalizing HIV Prevention Programs: Recommendations From Those Most Impacted by HIV in the Deep South
Authors: Williams Michelle S. , Poteat Tonia , Bender Melverta , Ugwu Precious , Burns Paul A. 
Published: August 2021

Purpose: The incidence of new HIV infections is disproportionately high among Black men who have sex with men (BMSM) in Mississippi. Community-based organizations received funding through the ACCELERATE! initiative to implement interventions aimed at increasing BMSM’s access to HIV prevention, treatment and care interventions. Approach: We conducted a mixed methods evaluation of the ACCELERATE! initiative to assess its impact. We also explored factors that act as barriers to and facilitators of BMSM’s engagement in HIV prevention interventions. Setting: Interviews were conducted between July 2018 and February 2020. Participants: Thirty-six BMSM and 13 non-grantee key informants who worked in the field of HIV in Mississippi participated. Method: The qualitative data from the interview transcripts was analyzed using an iterative, inductive coding process. Results: We identified 10 key recommendations that were most common across all participants and that were aligned with UNAIDS Global AIDS Strategy strategic priorities. Several recommendations address the reduction of HIV- and LGBT-stigma. Two of the most common recommendations were to increase representation of the target population in health promotion program leadership and to include HIV with other Black health issues in community-based health education programs rather than singling it out. Another recommendation called for programs aimed at addressing underlying factors associated with HIV-risk behaviors, such as mental illness. Conclusion: Our results indicate that HIV education interventions in the Deep South need to be revitalized to enhance their reach and effectiveness.
A Study of PhD Courses and Curricula Across Schools of Social Work
Authors: Franklin Cynthia , Lightfoot Elizabeth , Nachbaur Melissa , Sucher Katharine 
Published: August 2021

Objectives This study explored courses offered by social work PhD programs, the variation in these courses by type of university, and how the courses compare to the Group for the Advancement of Doctoral Education in Social Work (GADE) Quality Guidelines. Study Methods Course curriculums of 84 GADE-affiliated social work PhD programs were double-blind coded. PhD directors verified codes and answered a brief survey. Findings A total of 1146 courses were coded into 28 categories. An average of six research and statistics courses were offered per program. Few programs offered courses in measurement, intervention research, meta-analysis, program evaluation, or grant writing. Most programs indicated that diversity, equity, and inclusion was infused in the curriculum. Less than half (41%) of PhD program directors indicated that GADE Quality Guidelines were influential. Conclusions PhD programs are offering more research and statistics courses than in the past, but GADE Quality Guidelines are not consistently followed.
The plague of privatization: A futures analysis of the zombification of education
Authors: Fjellman Anna-Maria , Haley Aimee 
Published: August 2021

The article re-imagines the current developments of Swedish education into a possible future. Historically, education was organized and funded by the state; however, reforms towards privatization in the 1990s implemented school choice, private schools and a tax-financed voucher system with the option of turning profits on education. A new judicial decision enforced the withholding of data on private ownership and economic spending in education from the public, as transparency was deemed to damage the competitiveness of private schools. Hence, generating profits and business advantage are prioritized over public interests as the organization and provision of education is progressively shaped by privatization. These changes are what prompted us to consider ‘what if all education was privatized’? The first part of the article reviews important developments in public education towards privatization and introduces our theoretical framework. The second part draws on aspects of speculative fiction in a dystopian scenario of an imagined educational apocalypse. The scenario starts in contemporary times and ends in 2121 where the education system is dominated by a financial conglomerate called Nescience Ltd. In this technologically advanced society, artificial intelligence systems have replaced educational institutions and teachers. Expensive tuition and fees have made people indebted to Nescience while learning is transformed into the manufacturing of alienated labourers. To understand these economic transitions and the position of Nescience as a knowledge provider in the future, we use the concept of ‘zombification’ to theorize the infection of privatization in the educational sector.
Gender Difference in Perceived Symptoms and Laboratory Investigations in Suspected and Confirmed COVID-19 Cases: A Retrospective Study
Authors: Ahmed Marwa Mostafa , Sayed Amal M. , El Abd Dina , Fares Samar , Said Marwa Sayed Mohamed , Elsayed Sedik Ebrahim Eman 
Published: August 2021

Background: Evaluating gender-specific effects of COVID-19 is important to develop effective therapeutic strategies. The aim of this study was to explore gender difference in perceived symptoms and laboratory investigations in suspected and confirmed cases. Methods: This is a retrospective study that included data from suspected COVID-19 patients during the first wave of the pandemic. Participants using the phone triaging system at Kasralainy outpatient clinics were included. The analyzed data included patient history and results of nasopharyngeal swab and laboratory data. Results: Out of 440 COVID-19 suspected cases, 56.36% were females. The perceived COVID-19 symptoms showed no significant gender difference in suspected cases while in confirmed cases females were 4 times more likely to complain of cough [OR (95% CI) 3.92 (1.316–11.68), P-value .014] and 5 times more likely to experience loss of smell or taste [OR (95% CI) 4.84 (1.62–14.43), P-value .005]. Laboratory markers revealed high levels of aspartate aminotransferase, alanine aminotransferase, blood urea, serum creatinine, creatine kinase, and serum ferritin in males and this was statistically significant ( P-value <.001) in suspected and confirmed cases. Females confirmed with COVID-19 were 80%, 97%, and 97% less likely to have high levels of ALT, creatin kinase, and serum ferritin [OR (95% CI) 0.20 (0.07–0.54), 0.07 (0.01–0.38), and 0.07 (0.01–0.90), P-value .002, .002, and .041, respectively]. Conclusion: Gender differences were found in laboratory markers in COVID-19 suspected and confirmed cases and in perceived symptoms in confirmed cases.
Levels of Physical Activity and Prevalence of Musculoskeletal Disorders Among Physicians in Saudi Arabia Post COVID-19 Lockdown: An Epidemiological Cross-Sectional Analysis
Authors: AlOmar Reem S. 
Published: August 2021

Introduction: Musculoskeletal disorders (MSDs) are common worldwide. Recommendations to reduce discomfort often commence with increasing physical activity levels. In Saudi Arabia, levels of physical activity prior to the COVID-19 pandemic were low. This cross-sectional study aims at estimating the prevalence of MSDs among Saudi physicians, as well as determining the pattern and level of physical activity post lockdown and examining their association. Methods: Physical activity levels were assessed via the International Physical Activity Questionnaire and MSDs were assessed via the Nordic Musculoskeletal Questionnaire. Chi-squared tests with significance levels of <.05 were performed to explore bivariate associations. Unadjusted and adjusted odds ratios (ORs) along with their 95% confidence intervals (CIs) were given by binary logistic regression analyses. Results: A total of 3492 physicians participated in this study, and over half of them (63.55%) reported low physical activity. Risk of MSDs increased with aging and with increasing BMI ( P for trend <.05). Females were more likely to report MSDs (OR = 1.23, 95% CI = 1.07-1.86), as well as physicians with a chronic condition (OR = 1.52, 95% CI = 1.24-1.37) and those who work in shifts (OR = 1.18, 95% CI = 1.03-1.37). Moderate activity conferred a non-significant protective effect (OR = 0.95, 95% CI = 0.79-1.13), whilst high physical activity had a non-significant increased risk of MSDs in this population. Conclusion: Physical activity in this population is astonishingly low, while prevalence of MSDs is relatively high. Significant factors include age, sex, shift work, and the presence of chronic conditions. Current results warrant the consideration of preventive measures for physicians.