bluuebunny/crossref_metadata_2025_split huggingface dataset:
The bilateral limb deficit (BLD) phenomenon during leg press: a preliminary investigation into central and peripheral factors
Authors: Whitcomb Emily , Ortiz Oscar , Toner Jacqueline , Kuruganti Usha 
Published: August 2021

AbstractBackgroundThe bilateral limb deficit (BLD) phenomenon suggests that lower forces are produced with bilateral limb contractions compared to the summed force produced when the same muscles are contracted unilaterally. While interhemispheric inhibition has been suggested as a cause of BLD, the origin of the deficit is yet to be determined. The aim of this study was to investigate central and peripheral factors responsible for the BLD during leg press using surface electromyography (EMG) and electroencephalography (EEG).MethodsFourteen adults (age = 23.7 ± 4.7 years old) completed bilateral (BL), unilateral left (UL) and unilateral right (UR) isometric leg press exercises. Bilateral limb ratio (BLR) was calculated similar to previous studies and surface EMG from three muscles of the quadriceps femoris (vastus lateralis, vastus medialis and rectus femoris) was used to measure the level of muscle activation. Movement related cortical potentials (MRCPs) over the left and right motor cortex areas (C3 and C4, respectively) were used to assess brain activity asymmetries reflecting central factors.ResultsNo significant difference was noted in the mean BLR (BLR = 94.8%), but a subset of ten participants did demonstrate a BLD (BLR = 81.4%,p < 0.01). Mean differences in relative activation were found among the three quadricep muscles (p < 0.001) with the right VM having significantly higher amplitude for the unilateral right (0.347 ± 0.318 mV) and bilateral right (0.436 ± 0.470 mV) conditions, respectively) than either the VL or RF (p < 0.05). The VL had significantly lower amplitudes in all conditions (0.127 ± 0.138 mV; 0.111 ± 0.104 mV; 0.120 ± 0.105 mV; 0.162 ± 0.147 mV for unilateral left, bilateral left, unilateral right, and bilateral right, respectively). However no overall significant differences were noted between bilateral and unilateral conditions. No significant differences in MRCPs were observed between brain activity of the C3 and C4 electrodes in any of the conditions.ConclusionWhile the sample size was low, this exploratory study noted the presence of BLD however the results did not provide evidence of significant limitations in either the EMG or EEG data.
Patients with PWS and related syndromes display differentially methylated regions involved in neurodevelopmental and nutritional trajectory
Authors: Salles Juliette , Eddiry Sanaa , Lacassagne Emmanuelle , Laurier Virginie , Molinas Catherine , Bieth Éric , Franchitto Nicolas , Salles Jean-Pierre , Tauber Maithé 
Published: August 2021

AbstractBackgroundPrader–Willi syndrome is a rare genetic neurodevelopmental disorder caused by a paternal deficiency of maternally imprinted gene expression located in the chromosome 15q11–q13 region. Previous studies have demonstrated that several classes of neurodevelopmental disorders can be attributed to either over- or under-expression of specific genes that may lead to impairments in neuronal generation, differentiation, maturation and growth. Epigenetic changes that modify gene expression have been highlighted in these disorders. One recent study focused on epigenetic analysis and compared patients with PWS with patients with other imprinting disorders. No study, however, has yet focused on epigenetics in patients with PWS specifically by comparing the mutations associated with this syndrome.ObjectiveThis study investigated the epigenetic modifications in patients with PWS and patients with PWS-related disorders caused by inactivation of two genes of the PWS chromosomal region, SNORD116andMAGEL2. Our approach also aimed to compare the epigenetic modifications in PWS and PWS-related disorders.MethodsWe compared genome-wide methylation analysis (GWAS) in seven blood samples from patients with PWS phenotype (five with deletions of the PWS locus, one with a microdeletion ofSNORD116and one with a frameshift mutation ofMAGEL2presenting with Schaaf–Yang syndrome), as well as two control patients. Controls were infants that had been studied for suspicion of genetic diseases that was not confirmed by the genetic analysis and the clinical follow-up.ResultsThe analysis identified 29,234 differentially methylated cytosines, corresponding to 5,308 differentially methylated regions (DMRs), which matched with 2,280 genes. The DMRs in patients with PWS were associated with neurodevelopmental pathways, endocrine dysfunction and social and addictive processes consistent with the key features of the PWS phenotype. In addition, the separate analysis for theSNORD116andMAGEL2deletions revealed that the DMRs associated with theSNORD116microdeletion were found in genes implicated in metabolic pathways and nervous system development, whereasMAGEL2mutations mostly concerned genes involved in macromolecule biosynthesis.ConclusionThe PWS is associated with epigenetic modifications with differences inSNORD116andMAGEL2mutations, which seem to be relevant to the different associated phenotypes.
Educational level, ethnicity and mortality rates in Israel: national data linkage study
Authors: Goldberger Nehama Frimit , Haklai Ziona 
Published: August 2021

Abstract
Background
Many studies have shown significant gaps in mortality, and cause specific mortality by educational status. This study investigated these measures in Israel by educational and ethnic status in recent decades.

Method
A mortality follow-up till 2017 was done of a cohort of Israeli residents aged 25–64 in 2000 who remained in Israel and had available educational data, grouped into under 8, 9–11, 12, 13–15 and 16 and above years of education. Indirect age adjustment was used to calculate Standard Mortality Ratios (SMRs) by sex and educational group, and a Cox regression model to assess relative risk of total and cause specific mortality controlling for age and ethnic group (Jews and Others and Arabs).The analysis was repeated for each ethnic group separately.

Results
2,776,422 persons were included of whom 174,792 (6.3%) died till 2017. SMR’s for total mortality of males and females with less than 8 years of education compared to 16 and over were 2.2 and 1.8, respectively. Corresponding HR were 2.13 (95% CI 2.08–2.18) and 1.77 (95% CI 1.72–1.82), respectively.
The highest cause specific hazard ratios in males were for homicide, 4.40 (95% CI 3.19–6.07), respiratory diseases, 4.01 (95% CI 3.61–4.44), infectious diseases, 3.55 (95% CI 3.15–3.19) and diabetes 3.41 (95% CI 3.06–3.79) and in females for diabetes, 4.41 (95% CI 3.76–5.16), infectious diseases, 4.16 (95% CI 3.52–4.91), respiratory diseases, 4.13 (95% CI 3.55–4.81), and heart disease, 2.96 (95% CI 2.66–3.29).
Education-adjusted risk of all-cause mortality for Arab males was 1.07 (1.05–1.09) times that of Jews and Others and non-significant in females. High mortality risk was found for Arab males and females compared to Jews and Others for homicide, diabetes, heart and cerebrovascular disease and for respiratory disease in males. Lower risk was found for suicide and infectious diseases in both sexes and
cancer in females.

Conclusion
We found significant effect of educational level on all-cause and cause specific mortality, particularly respiratory diseases, infectious diseases, diabetes and homicide. Our results highlight the importance of increasing the educational level of all groups in the population and of encouraging healthy behavior in the lower educated.
Cooperative beamforming for a double-IRS-assisted wireless communication system
Authors: Tian Guodong , Song Rongfang 
Published: August 2021

AbstractIntelligent reflecting surface (IRS) has emerged as an innovative and disruptive solution to boost the spectral and energy efficiency and enlarge the coverage of wireless communication systems. However, the existing literature on IRS mainly concentrates on wireless communication systems assisted by single or multiple distributed IRSs, which are not always effective. In view of this issue, this paper considers a special double-IRS-assisted wireless communication system, where IRS1 and IRS2 are deployed near the base station (BS) and the user, respectively, and the transmitted signals reach the user via the cascaded BS-IRS1-IRS2-user channel only. We cooperatively optimize transmit and passive beamforming on the two IRSs based on the particle swarm optimization (PSO) algorithm to maximize the received signal power. Simulation indicates that despite no direct line-of-sight (LoS) path from the BS to the user, an excellent signal-to-noise ratio (SNR) is available at the receiver with the aid of two IRSs, which demonstrates that it is feasible to assist communication by double reflection links composed of two IRSs. Additionally, we unexpectedly find that when the positions of the two IRSs are fixed, by exchanging the positions of the BS and the user, the obtainable SNRs are similar.
Trajectory tracking control of AGV based on time-varying state feedback
Authors: Shang Jin , Zhang Jian , Li Chengchun 
Published: August 2021

AbstractIn order to realize the automation of transport equipment, according to the automatic guided vehicle (AGV) kinematics model, the trajectory tracking control of AGV with front wheel steering and rear wheel drive is studied. Lyapunov function is used to ensure the global stability of the system. Time-varying state feedback method based on integral backstepping is adopted, introducing virtual feedback, a trajectory tracking controller for AGV with nonholonomic constraints is proposed. In order to ensure the smooth motion of AGV, the speed and acceleration limited strategy of AGV is introduced into the controller. Simulation results show that the algorithm is fast, accurate and globally stable for different paths.
Association between occupational exposures and sarcoma incidence and mortality: systematic review and meta-analysis
Authors: Edwards D. , Voronina A. , Attwood K. , Grand’Maison A. 
Published: August 2021

AbstractBackgroundSarcomas are a rare and heterogeneous group of tumors originating from mesenchymal or connective tissue. They represent less than 1% of all adult cancers. The etiology and epidemiology of sarcomas remain understudied and poorly understood. The main objective of our study was to systematically assess the association between various occupational exposures and risk of sarcomas.MethodsWe performed a systematic literature search using the PubMed, Scopus, EMBASE and Cochrane databases to identify relevant cohort and case–control studies. A meta-analysis method was applied on the incidence and mortality outcomes where the estimate with 95% confidence interval (CI) was obtained.ResultsWe included a total of 50 publications in our systematic review and 35 in meta-analysis. For exposures to phenoxy herbicides and chlorophenols, the pooled odds ratio (OR) for sarcoma was 1.85 (95% CI: 1.22, 2.82), based on 16 studies with 2254 participants, while the pooled standardized mortality ratio was 40.93 (95% CI 2.19, 765.90), based on 4 cohort studies with 59,289 participants. For exposure to vinyl chloride monomers the pooled risk ratios for angiosarcoma of the liver and other STS were 19.23 (95% CI 2.03, 182.46) and 2.23 (95 CI 1.55, 3.22) respectively based on 3 cohort studies with 12,816 participants. Exposure to dioxins was associated with an increased STS mortality; the pooled standardized mortality ratio was 2.56 (95% CI 1.60, 4.10) based on 4 cohort studies with 30,797 participants. Finally, woodworking occupation was associated with an increased risk of STS with the pooled OR of 2.16 (95% CI 1.39, 3.36).ConclusionsOur findings suggest a positive association between higher exposure to dioxins and increased mortality from STS, between cumulative exposure to vinyl chloride monomers and increased mortality from angiosarcoma of the liver and STS, and between woodworking occupation and STS incidence. These findings were all statistically significant.
Plant developmental stage drives the differentiation in ecological role of the maize microbiome
Authors: Xiong Chao , Singh Brajesh K. , He Ji-Zheng , Han Yan-Lai , Li Pei-Pei , Wan Li-Hua , Meng Guo-Zhong , Liu Si-Yi , Wang Jun-Tao , Wu Chuan-Fa , Ge An-Hui , Zhang Li-Mei 
Published: August 2021

Abstract
Background
Plants live with diverse microbial communities which profoundly affect multiple facets of host performance, but if and how host development impacts the assembly, functions and microbial interactions of crop microbiomes are poorly understood. Here we examined both bacterial and fungal communities across soils, epiphytic and endophytic niches of leaf and root, and plastic leaf of fake plant (representing environment-originating microbes) at three developmental stages of maize at two contrasting sites, and further explored the potential function of phylloplane microbiomes based on metagenomics.

Results
Our results suggested that plant developmental stage had a much stronger influence on the microbial diversity, composition and interkingdom networks in plant compartments than in soils, with the strongest effect in the phylloplane. Phylloplane microbiomes were co-shaped by both plant growth and seasonal environmental factors, with the air (represented by fake plants) as its important source. Further, we found that bacterial communities in plant compartments were more strongly driven by deterministic processes at the early stage but a similar pattern was for fungal communities at the late stage. Moreover, bacterial taxa played a more important role in microbial interkingdom network and crop yield prediction at the early stage, while fungal taxa did so at the late stage. Metagenomic analyses further indicated that phylloplane microbiomes possessed higher functional diversity at the early stage than the late stage, with functional genes related to nutrient provision enriched at the early stage and N assimilation and C degradation enriched at the late stage. Coincidently, more abundant beneficial bacterial taxa like Actinobacteria, Burkholderiaceae and Rhizobiaceae in plant microbiomes were observed at the early stage, but more saprophytic fungi at the late stage.

Conclusions
Our results suggest that host developmental stage profoundly influences plant microbiome assembly and functions, and the bacterial and fungal microbiomes take a differentiated ecological role at different stages of plant development. This study provides empirical evidence for host exerting strong effect on plant microbiomes by deterministic selection during plant growth and development. These findings have implications for the development of future tools to manipulate microbiome for sustainable increase in primary productivity.
A mixed methods exploratory evaluation of burnout in frontline staff implementing dialectical behavior therapy on a pediatric eating disorders unit
Authors: Couturier Jennifer , Ma Zechen , Rahman Liah , Webb Cheryl 
Published: August 2021

Abstract
Background
Eating disorders are life-threatening illnesses that commonly affect adolescents. The treatment of individuals with eating disorders can involve slow treatment progression and addressing comorbidities which can contribute to staff burnout. Dialectical behavior therapy (DBT) has emerged as a viable treatment option and has reduced staff burnout in several other settings. Our aim was to describe frontline staff burnout using mixed methodology on a DBT-trained combined inpatient/day hospital unit for pediatric eating disorders.

Method
Frontline staff were trained to provide DBT skills for adolescents with eating disorders. Twelve months following the training and implementation, they completed the Copenhagen Burnout Inventory (CBI) and a qualitative interview. Directed and summative content analyses were used.

Results
Eleven frontline staff including nurses, child life specialists and child and youth workers participated. The CBI revealed that only one staff member experienced high personal burnout, while another experienced high client-related burnout. Qualitative data indicated that all frontline staff felt DBT had the potential to reduce burnout.

Conclusion
Qualitative data indicate that staff believe that DBT may hold promise in reducing burnout for pediatric frontline staff who treat children and adolescents with eating disorders. Further study is needed.

Plain English summary
Understanding burnout is particularly important for nursing staff in inpatient and day hospital settings for eating disorders, as nursing staff generally have the most frequent patient contact; thought to be a risk factor for burnout. The reduction of burnout can prevent detrimental effects on job performance, personal well-being, and patient outcomes. Our exploratory study shows that frontline staff believe that DBT may have the potential to reduce burnout in staff treating children and adolescents with eating disorders in a combined inpatient/day hospital setting. Further study is needed in this area.
Virtual cleaning of works of art using deep convolutional neural networks
Authors: Maali Amiri Morteza , Messinger David W 
Published: August 2021

Abstract
A varnish layer that is applied to a painting, generally to protect it, yellows over time, deteriorating the original look of the painting. This prompts conservators to undertake a cleaning process to remove the old varnish and apply a new one. Providing the conservators with the likely appearance of the painting before the cleaning process starts can be helpful to them, which can be done through virtual cleaning. Virtual cleaning is simply the simulation of the cleaning process. Previous works in this area required the method to have access to black and white paint regions, or physically removing the varnish first at a few spots. Through looking at the problem of virtual cleaning differently, we try to address those shortcomings. To do so, we propose using a convolutional neural network (CNN) to tackle the problem of virtual cleaning. The CNN is trained on artificially yellowed images of people, urban and rural areas, and color charts, as well as their original versions. The network is then applied to various paintings with similar scene content. The results of the method are first compared to the only physical model in the virtual cleaning field. We compare the outputs from the proposed method and the physical model by visualization as well as a quantitative measure that calculates the spectral similarity between the outputs and the reference images. These results show that the proposed method outperforms the physical model. The CNN is also applied to images of the Mona Lisa and The Virgin and Child with Saint Anne, both painted by Leonardo da Vinci. Results show both a qualitative and quantitative improvement in the color quality of the resulting image compared to their reference images. The CNN developed here is also compared to a CNN that has been developed for the purpose of image colorization in the literature to demonstrate the effectiveness of the CNN devised here, showing that the CNN architecture herein leads to a better result. The novelty of the work proposed herein lies in two premises. First, the accuracy of the method, which is demonstrated through comparison with the only physical approach derived until now. Second is the generalizability of the method which is shown through blindly applying the method to two famous works of art for which no information but an RGB image of the uncleaned artwork is known.
The impact of first and second wave of COVID-19 on knee and hip surgeries in Sweden
Authors: Dell’Isola Andrea , Kiadaliri Ali , Turkiewicz Aleksandra , Hughes Velocity , Magnusson Karin , Runhaar Jos , Bierma-Zeinstra Sita , Englund Martin 
Published: August 2021

Abstract
Purpose
To investigate the impact of COVID-19 in Sweden on rates of knee and hip surgeries.

Methods
We used healthcare data for the population of the southernmost region in Sweden (1.4 million inhabitants). We did an interrupted time-series analysis to estimate changes in rates and trends of joint replacements (JR), arthroscopies, and fracture surgeries for knee or hip in April–December 2020 compared to pre-COVID-19 levels adjusting for seasonal variations.

Results
We found a drop of 54% (95% CI 42%; 68%) and 42% (95% CI 32%; 52%), respectively, in the rate of JRs and arthroscopies in April 2020 when compared to the counterfactual scenario. This was followed by an increase that brought the rates of JRs and arthroscopies back to their predicted levels also during the beginning of the second wave (November–December 2020). Acute fracture surgeries were largely unaffected, i.e. did not show any decrease as observed for the other surgeries.

Conclusions
In southern Sweden, we observed a marked decrease in elective knee and hip surgeries following the first wave of Covid-19. The rates remained close to normal during the beginning of the second wave suggesting that important elective surgeries for patients with end-stage osteoarthritis can still be offered despite an ongoing pandemic provided adequate routines and hospital resources.
Operationalization of self-regulation in the early years: comparing policy with theoretical underpinnings
Authors: Braund Heather , Timmons Kristy 
Published: August 2021

AbstractResearch has consistently demonstrated that self-regulation is essential for the development and preservation of health and well-being in the early years and across the lifespan. Based on the emerging literature on the important role of self-regulation in promoting healthy child development, policymakers have made efforts to include self-regulation skills in practice and policy documents worldwide. Despite efforts to include self-regulation skills in early years curriculum documents, there is limited understanding by teachers, scholars, and policymakers of what self-regulation is and how best to support it in the day-to-day classroom. This limited understanding is perpetuated by a lack of a unified definition of self-regulation. Thus, it becomes important to examine these efforts in a critical way. In Ontario, where the research was completed, a revised play-based full-day kindergarten program was introduced in 2016. In this research we use a qualitative document analysis approach to compare the conceptualization of self-regulation in Ontario’s revised play-based kindergarten program with theory-driven models of self-regulation from empirical research. Analysis was iterative, and themes emerged based upon a coding scheme developed by the research team. Results suggest that co-regulation has a powerful influence on student learning. In addition, the policy document de-emphasizes behavioral regulation and expands cognitive regulation to include more than inhibitory control. Lastly, the kindergarten program discusses metacognition in relation to the use of language to articulate one’s thinking with little attention to goal-directed behaviors. In this paper, explicit recommendations for policymakers and practitioners are provided to ensure that emerging conceptualizations of self-regulation are promoted in early years curricula. Further, empirical evidence is needed to support why it is necessary to understand emerging conceptualizations of self-regulation and outline implications for current early years curricula.