bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of pore morphology and moisture on CBM‐related sorption‐induced coal deformation: An experimental investigation
Authors: Chu Peng , Liu Qingquan , Wang Liang , Chen Ertao , Liao Xiaoxue , Liu Yuanyuan , Huang Wenyi , Cheng Yuanping 
Published: March 2021

AbstractCoalbed methane (CBM) is an important resource of energy. For CBM recovery, sorption‐induced coal deformation can cause significant reservoir permeability change. Moisture content and coal pore morphology affect the gas adsorption capacity and can alter the coal deformation of the coal seam. Therefore, it is crucial to establish a coal gas moisture‐coupled model for CBM production prediction. However, there are currently insufficient data available for quantitative analyses. In this paper, a series of typical sorption‐induced strain experiments were carried out during methane adsorption and desorption on coal samples with different metamorphic degrees and moisture content. The pore morphology and adsorption capacity of coals were measured to analyze the reason for different deformation of coals with various pore structures and moisture. Results show that the adsorption capacity and deformation is corresponding to the specific surface area of micropore, which first decreases and then increases with coal ranks. The deformation and adsorption gas content of dried coals is greater than that of natural moisture coals, which means that moisture can reduce the sorption capacity of coals, resulting in the decrease of gas adsorption‐induced coal deformation. There is also residual deformation of coal samples after gas desorption caused by the residual adsorbed gas in coals. This paper quantitatively investigates the effects of pore characteristics and moisture on coal deformation and the internal mechanism. This work will provide essential information for building out a fully cross‐coupled model of coal gas‐moisture relationships for CBM production prediction.
Differentiated Cells in Prolonged Hypoxia Produce Highly Infectious Native‐Like Hepatitis C Virus Particles
Authors: Cochard Jade , Bull‐Maurer Anne , Tauber Clovis , Burlaud‐Gaillard Julien , Mazurier Frédéric , Meunier Jean‐Christophe , Roingeard Philippe , Chouteau Philippe 
Published: March 2021

Background and Aims
Standard hepatitis C virus (HCV) cell‐culture models present an altered lipid metabolism and thus produce lipid‐poor lipoviral particles (LVPs). These models are thereby weakly adapted to explore the complete natural viral life cycle.

Approach and Results
To overcome these limitations, we used an HCV cell‐culture model based on both cellular differentiation and sustained hypoxia to better mimic the host‐cell environment. The long‐term exposure of Huh7.5 cells to DMSO and hypoxia (1% O2) significantly enhanced the expression of major differentiation markers and the cellular hypoxia adaptive response by contrast with undifferentiated and normoxic (21% O2) standard conditions. Because hepatocyte‐like differentiation and hypoxia are key regulators of intracellular lipid metabolism, we characterized the distribution of lipid droplets (LDs) and demonstrated that experimental cells significantly accumulate larger and more numerous LDs relative to standard cell‐culture conditions. An immunocapture (IC) and transmission electron microscopy (TEM) method showed that differentiated and hypoxic Huh7.5 cells produced lipoproteins significantly larger than those produced by standard Huh7.5 cell cultures. The experimental cell culture model is permissive to HCV–Japanese fulminant hepatitis (JFH1) infection and produces very‐low‐buoyant‐density LVPs that are 6‐fold more infectious than LVPs formed by standard JFH1‐infected Huh7.5 cells. Finally, the IC–TEM approach and antibody‐neutralization experiments revealed that LVPs were highly lipidated, had a global ultrastructure and a conformation of the envelope glycoprotein complex E1E2 close to that of the ones circulating in infected individuals.

Conclusions
This relevant HCV cell culture model thus mimics the complete native intracellular HCV life cycle and, by extension, can be proposed as a model of choice for studies of other hepatotropic viruses.
Valuable aspects of home rehabilitation in Sweden: Experiences from older adults
Authors: Johansson Anette , Ernsth Bravell Marie , Karlsson Ann Britt , Fristedt Sofi 
Published: March 2021

AbstractBackground and aimHome rehabilitation is an increasing service in many countries due to the aging population. The body of knowledge in home rehabilitation is growing but results are inconsistent, and there is still lack of knowledge from user perspectives to guide practice and home rehabilitation programs. The purpose of this study was to explore valuable aspects of home rehabilitation experienced by older adults.MethodsFourteen older persons (nine older adults and five next of kins) were interviewed about their experiences of receiving rehabilitation in their homes. Nine de‐identified interviews were analyzed as secondary data and with qualitative content analysis.ResultsA familiar home environment, inclusive collaboration, and the mastering of everyday life were aspects of value for older adults in home rehabilitation. Creating a tailor‐made rehabilitation together with competent staff, building trust, and providing a sense of security in their homes were also considered valuable.ConclusionWhen using the home as an arena for rehabilitation and collaboration, interventions can be planned based on the older adult's unique conditions and the knowledge and skills of the multidisciplinary team, including the older adult and their next of kin. A valuable home rehabilitation can then be achieved that creates motivation, which in the long term probably also generates desired effects for the older adult. More research is needed on older adult's experiences of content in home rehabilitation programs so that practice develops in accordance with citizens' needs, individual resources, and relationships.
Effects of inflation uncertainty and exchange rate volatility on money demand in Pakistan: Bayesian econometric analysis
Authors: Akbar Muhammad 
Published: March 2021

AbstractThe study explores determinants of money demand (M2) in a developing economy of Pakistan using annual data ranging 1976–2017. The study contributes by two ways. Firstly, it specifically examines the potential impact of exchange rate volatility and inflation uncertainty along with conventional determinants on money demand in Pakistan. Secondly, Bayesian Statistical inference is employed and the estimates are interpreted along with highest posterior density intervals (HPDI) with probability statements in order to cope with the issue of the instability of parameters. The analysis explores the positive impact of real income as well as share prices and the negative effect of interest rate on money demand as predicted by theory and earlier findings. Significant negative estimate of exchange rate shows that substitution effect overcomes wealth effect during exchange rate variations. But magnitude of exchange rate elasticity seems to depend upon strength of depreciation rate and/or future expectations, which may be considered an important research question for future work. Insignificance of exchange rate volatility for money demand in Pakistan is found which requires further research as to know about the behaviour of wealth effect and expectation effect during forex market uncertainty. Most importantly, inflation uncertainty is found to be a potential determinant of money demand in Pakistan. Rising uncertainty of inflation rate seems to have direct effects on precautionary and transaction motives of the demand for money. Findings of this study provides useful insights for policymaking in Pakistan as well as in other developing economies by suggesting inflation uncertainty as the potential determinant of money demand. Finally, Bayesian estimates along with HPDI estimates provide new information about the effects and particularly about the possible range of elasticities.
Approach to the acutely dyspnoeic cat
Authors: Borgeat Kieran , Pack Matthew 
Published: March 2021

Background: Dyspnoea, defined as difficult or laboured breathing, is a common feline presentation in primary care practice. Early clinical signs may be difficult for owners to identify at home and often dyspnoeic patients worsen with travel‐associated stress. As such, many cats first present to vets with severe respiratory distress. Acute cases are a diagnostic challenge due to the fragile and unstable nature of the patient.Aim of the article: This article describes how to strike a balance between the interventions that are required to stabilise an individual and achieve a diagnosis, while avoiding further deterioration by not doing too much too soon.
Safety and Efficacy of Oral Human Parathyroid Hormone (1-34) in Hypoparathyroidism: An Open-Label Study
Authors: Ish-Shalom Sofia , Caraco Yoseph , Khazen Nariman Saba , Gershinsky Michal , Szalat Auryan , Schwartz Phillip , Arbit Ehud , Galitzer Hillel , Tang Jonathan CY , Burshtein Gregory , Rothner Ariel , Raskin Arthur , Blum Miriam , Fraser William D 
Published: March 2021

ABSTRACT
The standard treatment of primary hypoparathyroidism (hypoPT) with oral calcium supplementation and calcitriol (or an analog), intended to control hypocalcemia and hyperphosphatemia and avoid hypercalciuria, remains challenging for both patients and clinicians. In 2015, human parathyroid hormone (hPTH) (1-84) administered as a daily subcutaneous injection was approved as an adjunctive treatment in patients who cannot be well controlled on the standard treatments alone. This open-label study aimed to assess the safety and efficacy of an oral hPTH(1-34) formulation as an adjunct to standard treatment in adult subjects with hypoparathyroidism. Oral hPTH(1-34) tablets (0.75 mg human hPTH(1-34) acetate) were administered four times daily for 16 consecutive weeks, and changes in calcium supplementation and alfacalcidol use, albumin-adjusted serum calcium (ACa), serum phosphate, urinary calcium excretion, and quality of life throughout the study were monitored. Of the 19 enrolled subjects, 15 completed the trial per protocol. A median 42% reduction from baseline in exogenous calcium dose was recorded (p = .001), whereas median serum ACa levels remained above the lower target ACa levels for hypoPT patients (&gt;7.5 mg/dL) throughout the study. Median serum phosphate levels rapidly decreased (23%, p = .0003) 2 hours after the first dose and were maintained within the normal range for the duration of the study. A notable, but not statistically significant, median decrease (21%, p = .07) in 24-hour urine calcium excretion was observed between the first and last treatment days. Only four possible drug-related, non-serious adverse events were reported over the 16-week study, all by the same patient. A small but statistically significant increase from baseline quality of life (5%, p = .03) was reported by the end of the treatment period. Oral hPTH(1-34) treatment was generally safe and well tolerated and allowed for a reduction in exogenous calcium supplementation, while maintaining normocalcemia in adult patients with hypoparathyroidism. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Probiotics ameliorates glycemic control of patients with diabetic nephropathy: A randomized clinical study
Authors: Jiang Hongyang , Zhang Yan , Xu Dongyan , Wang Qing 
Published: March 2021

AbstractObjectiveThis research aimed to explore the effects of probiotic administration on glycemic control and renal function in patients with diabetic nephropathy (DN).MethodsThe 101 participants were randomly divided into two treatment groups and 76 patients were included in the final analysis. In 76 patients with diabetic nephropathy of type 2 diabetes, a randomized double‐blind and placebo‐controlled clinical trial was conducted to evaluate the administration of 3.2 × 109 CFU probiotic supplements per day (Bifidobacterium bifidum, 1.2 × 109 CFU, Lactobacillus acidophilus 4.2 × 109 CFU, Streptococcus thermophilus 4.3 × 109 CFU) for 12 weeks on glycemic control of patients, including fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin (HbA1c), microalbuminuria/creatinine (mAlb/Cr) and estimated glomerular filtration rate (eGFR) levels. The placebo group daily received empty capsules filled with starch.ResultsAfter 12 weeks, the administration of probiotics demonstrated a significant reduction in fasting blood glucose (10.68 ± 3.24 mmol/L before vs. 7.81 ± 2.77 mmol/L after, p < 0.05), HbA1c (8.19 ± 1.60% before vs. 7.32 ± 1.20% after, p < 0.05) and mAlb/Cr (101.60 ± 22.17 mg/g before vs. 67.53 ± 20.11 mg/g after, p < 0.05), while only mAlb/Cr level was significantly lower in the probiotic group than in the placebo group after intervention (67.53 ± 20.11 mg/g vs. 87.71 ± 23.01, p < 0.05). Meanwhile, there was no significant reduction of 2 h postprandial blood glucose level (18.95 ± 5.23 mmol/L vs. 17.35 ± 6.28 mmol/L, p = 0.24) and eGFR (84.34 ± 6.97 ml/min vs. 82.8 ± 8.72 ml/min, p = 0.45) in patients before and after probiotic intake. In addition, the placebo group failed to show any significant change of these parameters.ConclusionThis clinical study revealed probiotic administration could ameliorate glycemic control of patients with diabetic nephropathy, potentiating its therapeutic potential in clinical application.
Phonon anharmonicity of thermoelectric material HfTe5 studied by Raman spectroscopy
Authors: Xie Qiyun , Xu Lihuan , Hu Chengxiang , Chen Limin , Zheng Jiajin , Wang Wei , Yin Handi , Cheng Guofeng , Ai Xiaoqian 
Published: March 2021

AbstractThe understanding of phonon–phonon anharmonic effect in HfTe5 is essential not only for fundamental scientific interest but also for its potential thermoelectric applications. Here, rectangular ribbon‐shaped HfTe5 single crystals have been grown. Raman spectroscopy is further utilized to investigate the phonon anharmonicity of HfTe5 by quantifying the temperature dependence of the phonon mode softening and broadening. We focus on the temperature range from 80 up to 400 K since obvious surface oxidation occurs at higher temperatures. It is found that four phonon anharmonic effects are non‐negligible. The phonon lifetime is greatly reduced by the enhancement of phonon scattering, resulting in the low thermal conductivity in HfTe5 single crystals.
Bobcat Hair Cortisol Correlates with Land Use and Climate
Authors: Carroll Rory P. , Litvaitis Marian K. , Foxall Thomas 
Published: March 2021

ABSTRACTBobcats (Lynx rufus) have been increasing in abundance in the northeast United States despite a corresponding trend of increased anthropogenic land uses. Inhabiting areas of high human land use can affect stress levels, and hence cortisol titers, for wildlife species by increasing frequency of human interaction and altering habitats. In turn, increased cortisol levels can have negative effects at the individual and population level including decreased immune function, slowed growth and tissue repair, reduced reproductive capacity, and nutritional deficiencies. We quantified cortisol in bobcats across New Hampshire and Vermont, USA, using hair samples, then explored associations between hair cortisol and various organismal, land use, land cover, and climatic variables at 2 different spatial scales. Hair cortisol differed by season and bobcat mass. On average, cortisol levels were higher in fall than in spring, and larger bobcats had lower cortisol levels. Anthropogenic land uses—especially residential and agricultural uses—were the most important predictors of hair cortisol at the town scale ( area = 93 km2). At a larger scale (Wildlife Management Units; area = 1,256 km2), temperature and precipitation were better predictors of hair cortisol, suggesting that extreme weather may have significant effects on bobcat population dynamics. Our results highlight the importance of landscape composition and local conditions in the sustainable management of furbearer populations. © 2021 The Wildlife Society.
Cotton Ball Self‐Retraction Technique: A Novel Surgical Method Used During Microflap Dissection
Authors: Kim Joo Hyun , Park Joong Soo , Choi Hong‐Shik , Hwang Yong Sung , Ban Myung Jin , Park Jae Hong 
Published: March 2021

Objectives/HypothesisMicrosurgical removal with a microflap technique via direct laryngoscopy is considered the primary treatment option for vocal cysts. However, the microflap technique is technically difficult and challenging. Therefore, we developed the “cotton ball self‐retraction” technique to aid in vocal cyst surgery and reduce the cyst rupture incidence. This study aimed to evaluate the efficacy of this technique in microflap dissection for vocal cysts by comparing its treatment outcomes with those of the conventional technique as well as investigate the rate of recurrence using a retrospective chart review.Study DesignA retrospective review.MethodsWe reviewed the medical records of 169 patients who underwent surgery with the microflap technique for vocal cysts from December 2006 to December 2017. The patients were divided into two groups: 78 patients underwent laryngomicrosurgery using the conventional microflap technique (group A), whereas the remaining 91 patients underwent surgery with the microflap technique with cotton ball self‐retraction (group B). The voice outcomes and operative data of the two groups were retrospectively reviewed and compared.ResultsThe cyst ruptured intraoperatively in 42 of 78 (53.8%) patients in group A and 17 of 91 (18.6%) patients in group B. Recurrence during the follow‐up period was detected in 9 of 78 (11.5%) patients in group A and 2 of 91 (2.19%) patients in group B. The degrees of improvement in assessed voice parameters were not significantly different between the groups.ConclusionThe cotton ball technique allows accurate and effective dissection during microflap surgery for intracordal cysts.Level of Evidence3 Laryngoscope, 131:E2553–E2557, 2021
Continuously tunable substrate integrated coaxial line bandpass filters with liquid crystal technology
Authors: Li Xiang 
Published: March 2021

AbstractThis letter introduces two continuously tunable bandpass filters with substrate integrated coaxial line (SICL) and liquid crystal (LC) technologies. The tunability of the filters is a kind of electric tuning, achieved by the permittivity changing of the LC material filled in the SICL cavities. The SICL resonator and the electric and magnetic coupling between the resonators are investigated. Then, fourth‐order direct‐coupled and cross‐coupled tunable filters (Filter I and II) with center frequency of 6.5 GHz are designed, fabricated, and measured. The experimental results show that the continuous tuning ranges are 220 and 280 MHz for Filter I and II, respectively. Furthermore, the insertion losses of the Filter I and II are 3.93–4.78 dB and 3.65–4.3 dB over the whole tuning range.
French physiotherapy management of rotator cuff related shoulder pain: An observational study
Authors: Riera Jerome , Smythe Andrew , Malliaras Peter 
Published: March 2021

ABSTRACTBackgroundRotator cuff related shoulder pain (RCRSP) is a common and disabling cause of shoulder pain contributing to great socio‐economic costs. Conservative management is recommended as first‐line treatment, with studies performed in the United Kingdom, Belgium, the Netherlands and Australia finding practice generally consistent with guideline recommendations. Current French guidelines for management of RCRSP were published more than a decade ago, and it is unknown if French physiotherapists manage RCRSP in line with the current guideline recommendations. The aim of this survey is to evaluate if management delivered by French physiotherapists for RCRSP is in line with the current evidence.MethodsA cross‐sectional online survey was conducted and disseminated through various social media platforms and a mailing list from December 2018 to March 2019.ResultsTwo hundred and six French physiotherapists completed the survey. The results demonstrated that the majority of physiotherapists provide care consistent with recommended guideline management, through the delivery of exercise and education. Ideology and specific parameters of treatment delivery, particularly exercise treatment, were highly variable among the cohort, but comparable to findings among physiotherapists in the United Kingdom, Belgium, the Netherlands and Australia.ConclusionFrench physiotherapists are broadly consistent with providing guideline recommended care of RCRSP; however, heterogeneity exists in the ideals and practice of specific treatment delivery, particularly within exercise management.
Integrated management to reduce fistula‐related long‐term complications and improve the quality of life after arteriovenous fistula surgery: A retrospective cohort study
Authors: Ning Min , Luo Dan , Ye Gang , Zhang Ting , Liu Li , Peng Fumei 
Published: March 2021

AbstractAimProper arteriovenous fistula (AVF) management is crucial to avoid AVF complications and prolong its useful life for maintenance haemodialysis (MHD).DesignRetrospective cohort study.MethodsPatients on MHD who underwent AVF surgery at the Wuhan Third Hospital between January 2018 and July 2018.ResultsA total of 144 patients were included, with 56 in the integrated group and 88 in the routine group. There were no differences between the two groups in terms of sex (p = .61), age (p = .62) and type of primary kidney disease (p > .99). At 1 year, the integrated group had significantly fewer fistula‐related complications than the routine group (3.6% versus. 23.9%, p < .001). AVF functional scores were lower in the integrated group compared with the routine group (0.1 ± 0.5 versus. 0.8 ± 0.8, p < .001). The pain scores were lower in the integrated group than in the routine group (1.2 ± 0.4 versus. 1.8 ± 0.9, p < .001).
Degradation analysis of epoxy resin composites reinforced with bioprotein: Effects of hydrolysis using papain and bromelain
Authors: Faiza Wan , Firouzi Amin , Islam Muhammad Remanul , Sumdani Gulam , Taher Abu 
Published: March 2021

AbstractDegradation of epoxy‐based composites reinforced with fish scale particles was studied using two enzymes, papain, and bromelain. Mechanical, structural, thermal, and morphological properties of the composites were characterized. Results showed a significant deterioration of the properties after the degradation of the composites. Flexural strength of the composites was reduced by 38% and 13%, respectively, due to the presence of the enzymes. Crystalline temperature of the composites was significantly decreased by 18°C due to the enzymatic attack. A significant amount of weight loss occurred during the degradation process. In addition, the structural and surface properties of the composites demonstrated the degradation of the polymer and the fish scale. Overall, fish scale can be used as a potential filler to tune the mechanical properties of the polymers and to facilitate the degradation of the polymers.