bluuebunny/crossref_metadata_2025_split huggingface dataset:
The accuracy of diagnostic indicators for coeliac disease: A systematic review and meta-analysis
Authors: Elwenspoek Martha M. C. , Jackson Joni , O’Donnell Rachel , Sinobas Anthony , Dawson Sarah , Everitt Hazel , Gillett Peter , Hay Alastair D. , Lane Deborah L. , Mallett Susan , Robins Gerry , Watson Jessica C. , Jones Hayley E. , Whiting Penny 
Published: October 2021

Background
The prevalence of coeliac disease (CD) is around 1%, but diagnosis is challenged by varied presentation and non-specific symptoms and signs. This study aimed to identify diagnostic indicators that may help identify patients at a higher risk of CD in whom further testing is warranted.

Methods
International guidance for systematic review methods were followed and the review was registered at PROSPERO (CRD42020170766). Six databases were searched until April 2021. Studies investigating diagnostic indicators, such as symptoms or risk conditions, in people with and without CD were eligible for inclusion. Risk of bias was assessed using the QUADAS-2 tool. Summary sensitivity, specificity, and positive predictive values were estimated for each diagnostic indicator by fitting bivariate random effects meta-analyses.

Findings
191 studies reporting on 26 diagnostic indicators were included in the meta-analyses. We found large variation in diagnostic accuracy estimates between studies and most studies were at high risk of bias. We found strong evidence that people with dermatitis herpetiformis, migraine, family history of CD, HLA DQ2/8 risk genotype, anaemia, type 1 diabetes, osteoporosis, or chronic liver disease are more likely than the general population to have CD. Symptoms, psoriasis, epilepsy, inflammatory bowel disease, systemic lupus erythematosus, fractures, type 2 diabetes, and multiple sclerosis showed poor diagnostic ability. A sensitivity analysis revealed a 3-fold higher risk of CD in first-degree relatives of CD patients.

Conclusions
Targeted testing of individuals with dermatitis herpetiformis, migraine, family history of CD, HLA DQ2/8 risk genotype, anaemia, type 1 diabetes, osteoporosis, or chronic liver disease could improve case-finding for CD, therefore expediting appropriate treatment and reducing adverse consequences. Migraine and chronic liver disease are not yet included as a risk factor in all CD guidelines, but it may be appropriate for these to be added. Future research should establish the diagnostic value of combining indicators.
Age-Specific Rates and Time-Courses of Gastrointestinal and Nongastrointestinal Complications Associated With Screening/Surveillance Colonoscopy
Authors: Ladabaum Uri , Mannalithara Ajitha , Desai Manisha , Sehgal Maanek , Singh Gurkirpal 
Published: October 2021

Introduction:
The rates of serious cardiac, neurologic, and pulmonary events attributable to colonoscopy are poorly characterized, and background event rates are usually not accounted for.

Methods:
We performed a multistate population-based study using changepoint analysis to determine the rates and timing of serious gastrointestinal and nongastrointestinal adverse events associated with screening/surveillance colonoscopy, including analyses by age (45 to <55, 55 to <65, 65 to <75, and ≥75 years). Among 4.5 million persons in the Ambulatory Surgery and Services Databases of California, Florida, and New York who underwent screening/surveillance colonoscopy in 2005–2015, we ascertained serious postcolonoscopy events in excess of background rates in Emergency Department (SEDD) and Inpatient Databases (SID).

Results:
Most serious nongastrointestinal postcolonoscopy events were expected based on the background rate and not associated with colonoscopy itself. However, associated nongastrointestinal events predominated over gastrointestinal events at ages ≥65 years, including more myocardial infarctions plus ischemic strokes than perforations at ages ≥75 years (361 [95% confidence intervals {CI} 312–419] plus 1,279 [95% CI 1,182–1,384] vs 912 [95% CI 831–1,002] per million). At all ages, the observed-to-expected ratios for days 0–7, 0–30, and 0–60 after colonoscopy were substantially >1 for gastrointestinal bleeding and perforation, but minimally >1 for most nongastrointestinal complications. Risk periods ranged from 1 to 125 days depending on complication type and age. No excess postcolonoscopy in-hospital deaths were observed.

DISCUSSION:
Although crude counts substantially overestimate nongastrointestinal events associated with colonoscopy, nongastrointestinal complications exceed bleeding and perforation risk in older persons. The inability to ascertain modifications to antiplatelet therapy was a study limitation. Our results can inform benefit-to-risk determinations for preventive colonoscopy.
Technological transition from IPv4 to IPv6 at SNR
Authors: Salinas Gonzalez Andersson 
Published: October 2021

Summary.
Introduction: The article is the product of the research “Technological transition IPv4 - IPv6 protocol" developed at the Francisco José de Caldas District University in 2020.
Problem: There is no detailed plan for the transition to IPv6 for the SNR that solves the support and connectivity problems of new devices to compete more efficiently in the telecommunications market for access to officials and the population.
Objective: To Generate a transition process plan that includes a detailed description of the phases and includes the key activities for said transition.
Methodology: This article, therefore, describes the research and implementation project that led to determine activities, phases and products corresponding to the technological transition from IPv4 to IPv6 in the SNR.
Results: The scope is visualized, as well as the documentary assurance through actions and recommendations of the change.
Conclusion: It is evident that, after complying with a proposed evaluation methodology, the experience can be characterized as a case of success, since it facilitated the pertinent decision making within the process of adopting the new protocol.
Originality: Through this research, the three transition phases suggested by the Ministry of Information Technologies and Communications (MinTIC) are contemplated.
Limitations: The technological transition from the IPv4 to IPv6 protocol is limited to the fact that the process is not immediate but transitory, so it must be supported by transition mechanisms that allow the coexistence of both protocols.
A kiegyezés témája bécsi lapokban
Authors: Rózsa Mária 
Published: October 2021

Die Aufnahme des österreichisch-ungarischen Ausgleichs 1867 wird in vier österreichischen Zeitungen von 1867 an bis 1869 untersucht und dargestellt. Der Wanderer (1814–1873) ließ mehrmals ungarische Interessen des freiheitlichen Kreises um Ferenc Deák zu Wort kommen, dank der Vermittlung zahlreicher ungarischer Mitarbeiter des Blattes. Hier sei bloß der hervorragende ungarische Journalist, Max Falk hervorgehoben werden. Die Herausgeber und Redakteure der zentralistisch-großösterreichischen liberalen Presse waren in erster Linie marktorientiert, sie interessierte vor allem der Gewinn bzw. der Erfolg des Blattes, sie wollten bloß schnell informieren. Die Debatte wurde als Organ der konservativen ungarischen Kräfte gegründet, unterstützte und besprach die Möglichkeiten und Wege des Ausgleichs. Die Neue Freie Presse als eine moderne liberale Zeitung vertrat Ideen des Liberalismus konsequent und ohne Voreingenommenheit. Ungarn betrachtete sie als einen Bestandteil des Habsburgischen Reiches, sie erhob ihr Wort mehrmals für die Interessen der anderen Nationalitäten und vertrat die Meinung, dass durch den Ausgleich die Ungarn mehrere Privilegien enthielten als die anderen Nationalitäten.
Legal Regulation of Re-Domiciliation in the Russian Federation
Authors: Konduktorov A. S. 
Published: October 2021

In summer 2020, the Russian Federation initiated amendments to agreements on double taxation avoidance concluded with foreign States. The President of the Russian Federation outlined the goal of this procedure, namely: to ensure the collection of tax on dividends and other payments in the amount of at least 15%. It is extremely curious that the change in such tax agreements correlates with the legal institution of the re-domiciliation of foreign companies to the Russian jurisdiction (to special administrative regions on the Oktyabrsky and Russian Islands). New provisions of agreements on the avoidance of double taxation in conjunction with the re-domiciliation procedure, as well as the existing mechanism for voluntary declaration of accounts and assets, can potentially bring the fight against offshorization of the domestic economy to a new level.The aim of the study is to compare the financial and other operating conditions of an international company registered in the order of re-domiciliation in a Russian special administrative region and an organization registered in a “low-tax” (offshore) jurisdiction. To achieve this goal, analytical and comparative legal research methods were used, which made it possible to draw the following conclusions: in the changing circumstances, the Russian special administrative regions are approaching in terms of the conditions for carrying out commercial activities and the volume of financial preferences provided to traditional offshore jurisdictions. However, in order to activate the process of re-domiciliation of foreign companies to the Oktyabrsky and Russky Islands, it is necessary to eliminate the shortcomings of legal regulation by amending the existing regulatory legal acts.
Refinements to the Graves–Pitarka Kinematic Rupture Generator, Including a Dynamically Consistent Slip-Rate Function, Applied to the 2019 Mw 7.1 Ridgecrest Earthquake
Authors: Pitarka Arben , Graves Robert , Irikura Kojiro , Miyakoshi Ken , Wu Changjiang , Kawase Hiroshi , Rodgers Arthur , McCallen David 
Published: October 2021

ABSTRACTThe main objective of this study is to develop physics-based constraints on the spatiotemporal variation of the slip-rate function using a simplified dynamic rupture model. First, we performed dynamic rupture modeling of the 2019 Mw 7.1 Ridgecrest, California, earthquake, to analyze the effects of depth-dependent stress and material friction on slip rate. Then, we used our modeling results to guide refinements to the slip-rate function that were implemented in the Graves–Pitarka kinematic rupture generation technique. The dynamic ruptures were computed on a surface-rupturing, planar strike-slip fault that includes a weak (negative to low-stress-drop) zone in the upper 4 km of the crust. Below the weak zone, we placed high-stress-drop patches designed to mirror the large-slip areas seen in various rupture model inversions of the event. The locations of the high-stress-drop patches and the hypocenter were varied in multiple realizations to investigate how changing the dynamic conditions affected the resulting rupture kinematics, in particular, the slip rate. From these simulations, we observed a systematic change in the shape of the slip-rate function from Kostrov type below the weak zone to a predominantly symmetric shape within the weak zone, along with a depth-dependent reduction of peak slip rate. We generalized these shallow rupture features into a depth-dependent parametric variation of the slip-rate function and implemented it in the Graves–Pitarka kinematic rupture model generator. The performance of the updated kinematic approach was then verified in 0–4 Hz simulations of the Mw 7.1 Ridgecrest earthquake, which showed that incorporating the depth-dependent variation in the shape of the slip-rate function improves the fit to the observed near-fault ground motions in the 0.5–3 s period range.
Tratamento Superficial por Plasma em PVC Plastificado para Aplicações Decorativas por PVD
Authors: Pasqual Eduardo Radaelli , Soares Márcio Ronaldo Farias 
Published: October 2021

A modificação superficial de materiais poliméricos tem levado a importantes avanços para a geração de novas aplicações industriais, além de permitir a substituição de polímeros de engenharia por materiais de custo menos elevado. Neste contexto, estudamos a modificação superficial de um sistema polimérico à base de PVC-DEHP, via tratamento por plasma de N2O2, aplicado a metalização decorativa por deposição física de vapor (PVD). Para este sistema estudado, análises por ATR-FTIR não revelaram alterações significativas na superfície do composto além da indicação da presença de hidroxilas (3200-3500cm-1), e alterações na região das carbonilas (1720cm-1) após a exposição ao plasma. Análises por AFM revelaram que a rugosidade superficial é aumentada, apresentando-se constante (46,59 ± 9,51nm) acima de 240 segundos de tratamento. Efeito similar de estabilização é observado em medidas de ângulo de contato, onde após uma redução em 36% em seu valor mantém-se constante (39° ± 4º) para tratamentos com tempos acima de 240 segundos, apresentando-se mais hidrofílica. Ensaios de adesão Pell Test sobre a camada metalizada indicam que o tempo de 240 segundos de tratamento por plasma foi o tempo mínimo para atingir uma adesão suficiente para este sistema, apresentando uma área de material removido inferior a 5%. http://dx.doi.org/10.18226/23185279.v9iss2p47
Managing a bullet inside the orbit in lieu of a rifle – A video demonstration
Authors: Das Deepsekhar , Agrawal Sahil , Tripathi Manasi , Panigrahi Arnav , Gupta Saloni 
Published: October 2021

Bullet injuries to the orbit are rare occurrences in a civilian’s life and are usually associated with severe ocular morbidity. The amount of damage inflicted by a bullet depends on various factors like the distance of the shooter from the victim, the speed of the bullet, the angle of impact, the site of damage, etc. The authors here report a case where a male teenager presented to the ophthalmology casualty with a history of gunshot injury to his left eye. A foreign body was noted to be lodged in his left orbit on radiological imaging causing vitreous haemorrhage and traumatic optic neuropathy. The foreign body was then surgically removed from the orbit. It was the bullet of a rifle 3.2 cm long. Intraorbital foreign body management must be tailored according to their type and location as well as to the clinical characteristics of the patient
The Pattern of Ear, Nose & Throat (Ent) Surgeries in A Secondary Health Centre in Enugu South Local Government Area of Enugu State Sourth-East, Nigeria
Authors: Anekpo Chijioke C. , Okpara Titus C. 
Published: October 2021

There is a wide spectrum of ear, nose and throat surgical conditions affecting both children and adults in Nigeria. This study aimed at determining the prevalence, socio-demographic features, types of ear, nose and throat surgical procedures in a secondary health centre in Enugu.
Patients and Methods:
This was a retrospective hospital based study of ENT clinic operation booking register and theatre operation register. Data obtained were collated, documented and statistically analysed using SPSS version 20.0 software.
Result:
A total of 75 patients were operated at the centre during the period under review. The female to male was 1:1:2. The age range was from 1 year to 85years. The indication for surgeries involving the throat were 67 (89.3%). The nose 7(9.2%). No surgery was performed in the ear. Adenotosillectomy 52(69.3) was the commonest surgery performed is in throat while polypectomy 4(5.3%) occurred more in the nose.
Conclusion:
Resources for Ear, Nose and throat surgeries in Enugu South Local Government are grossly inadequate. There is need for partnership with the Local Government administrator to upgrade the facilities.
Revisitando la indicación de la mastectomía profiláctica contralateral en pacientes con Síndrome de Li-Fraumeni y cáncer de mama. Reporte de un caso
Authors: Briceño-Morales Ximena , Briceño-Morales Clara , Guerrero-Macías Silvia Inés , Pedroza-Durán Ana María , Súarez-Rodríguez Raúl Alexis 
Published: October 2021

Objetivo: describir el caso de una paciente con Síndrome de Li-Fraumeni (SLF) y cáncer de mama, en quien se cuestionó el beneficio en la supervivencia de la mastectomía profiláctica contralateral (MPC); asimismo, se pretende hacer una discusión crítica acerca de la evidencia que soporta este procedimiento en esta población.
Presentación del caso: mujer de 37 años con cáncer de mama y múltiples antecedentes familiares de cánceres de temprana aparición del espectro del SLF, en quien, durante la adyuvancia hormonal, se confirmó una variante patogénica en el gen TP53. La paciente fue presentada en la Junta Multidisciplinaria del Servicio de Mama de un Centro Oncológico de referencia en Colombia, con el fin de discutir el beneficio de la MPC. La decisión de la junta fue no realizar la MPC. Después de 30 meses de seguimiento la paciente se encuentra libre de enfermedad.
Conclusión: no existe evidencia que analice, de forma particular, el impacto de la MPC en la supervivencia de las pacientes con SLF y cáncer de mama. Sin embargo, a la luz del conocimiento actual no es posible generalizar la conducta de omitir esta cirugía profiláctica. Es importante reportar los casos en los que se decida realizar u omitir este procedimiento con el fin de incrementar el cuerpo de la evidencia, dado que existen limitaciones para construir grandes cohortes o estudios experimentales exclusivos para esta alteración genética.
PERBEDAAN TINGKAT KONSUMSI DAN KADAR KOLESTEROL DARAH ANTARA PEROKOK DAN NON PEROKOK
Authors: Fahmawati Dina 
Published: October 2021

Cigarette smoke contains nicotine which disturbs health. Nicotine is capable of reducing the taste of food, so there is appetite suppressant. The ability of nicotine in increasing blood liposuction process can affect the increase in blood cholesterol level. The research aims to study the difference between food intake and blood cholesterol level between smokers and non-smokers. This study was a comparative observational analytic study using cross-sectional design. The data of particular subjects and smoking habit were obtained from the questionnaire. The food intake was obtained by interview using 2x24 hours food recall form while the blood cholesterol level was obtained by blood sampling which was then analyzed using laboratory test. The subjects were 13 smokers and 13 non-smokers, taken by simple random sampling. The data were analyzed by Independent t-Test. The results have suggested that the difference in the average food intake and blood cholesterol level between smokers and non-smokers were not significant. The substantial average difference was found in the level of cholesterol intake, so the statistical test has showed a significant difference, p-value = 0.005 < α(0.05). Smoking has a harmful effect for health so people must decrease its consumption or stay abstinent from it. The longer human get exposed to cigarette, the more susceptible they get the illness from it.
GAMBARAN PERSEPSI PENYAKIT TERHADAP KESEHATAN FUNGSI PARU PADA PASIEN ASMA DI SURABAYA
Authors: Lorensia Amelia , Suryadinata Rivan Virlando , Ratnasari Richa 
Published: October 2021

Asthma could affect quality of life and decrease productivity. The worsening of asthma symptoms also affected lung function. Symptoms of asthma could be control by self-management. The patient's behavior in self-management influenced by his perception of asthma. This research aims to determine effect of perception of disease on health function of parents in asma patients in surabaya. Research using observational methods with cross sectional design. Research Subjects were outpatient asthma patients aged 17-25 years. Data collection was conducted from June 2015 to January 2016 in Surabaya, to 27 people. Assessment of asthma perception use Illness Perception Questionnaire (IPQ) and health condition of lung function with peak flow meter to assess PEF (peak expiratory flow). The results of this study indicate that both groups have a PEF value <50% of the estimated PEF value. The data showed no significant difference (p (0.766)> 0.05) between disease perceptions based on the number of asthma-related symptoms with lung function (PEF), with the greatest answer as the cause of asthma that is genetic. Therefore, the perception of asthma does not affect lung function (PEF) in adult asthma patients in Surabaya.
INVESTIGATION OF THE FEATURES OF NICKEL-MODIFIED MORDENITE ZEOLITES
Authors: Patrylak Lyubov , Voloshyna Yuliya , Pertko Olexandra , Yakovenko Anzhela , Povazhnyi Volodymyr , Melnychuk Oleksandr 
Published: October 2021

Zeolites are wide used materials in a range of processes of chemical, petrochemical, and nutritional industry. They are the active catalysts and sorbents, in particular, zeolites are characterized by high efficiency towards extraction of heavy and radioactive metals from the aqua medium. An important factor of high zeolite catalyst activity is preserving the integrity of the crystal structure. The purpose of this research was to check out the features of MOR zeolite modifications with nickel by means of low temperature nitrogen adsorption/desorption, IR-spectroscopy, and X-Ray Diffraction (XRD). Using ion exchange and following calcination the hydrogen form of zeolite was obtained. The last was impregnated by nickel in quantity of 1, 5, and 15 wt. %. The investigations of nickel-modified samples demonstrated that MOR-type zeolite was relatively resistant to the used manipulations. However, the hysteresis loops of their isotherms are observed. The last can be connected with mesoporosity appearance. The degree of zeolite destruction is found out to increase with rise of nickel content in the samples. Based on IR spectra analysis by means of checking out the ratio between intensity of bands at 560 and 440 cm-1 using Gaussian function in Origin medium the same conclusions were drawn. Crystalline structure of mordenite was confirmed by using XRD method, but minor quantitative destruction cannot be recognized without application of methods of the internal and external standards.
Influence of ultraviolet radiation on kinetic characteristics in erythrocytes
Authors: Almazova Оlena , Lysychenko Mycola 
Published: October 2021

Erythrocytes were irradiated with an ultraviolet lamp of the VMT type (λ = 253.7 nm). The kinetic characteristics in irradiated and non-irradiated blood samples were compared by the acid (chemical) erythrogram method and by the counter transport method. Obtained:
- by the method of acidic erythrograms it was found that in ultraviolet-irradiated blood samples there is a decrease in the time of half hemolysis.
- ultraviolet radiation increases the speed of counter movement of ions through erythrocyte membranes.
- a decrease in the time of half hemolysis and an increase in the rate of counter transfer of ions, irradiated blood samples, is due to a decrease in the "effective" thickness of the near-membrane diffusion layer - an immiscible layer of water adjacent to the erythrocyte membrane.
A decrease in the "effective thickness" of the near-membrane water layer changes the rate of metabolic processes in the "cell - intercellular medium" system, changing the mode of cell functioning. The altered mode of functioning is a biological response to light radiation. Red blood cells with an altered mode of functioning are stimulus signals that force the body to mobilize resources to fight pathology. These circumstances can predict the creation of a universal phototherapeutic equipment for extracorporeal blood irradiation based on LEDs with certain exposure parameters. Figs.: 4. Tabl.: 3. Refs.: 12 titles.