bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction accuracy of conventional and total keratometry for intraocular lens power calculation in femtosecond laser-assisted cataract surgery
Authors: Ryu Soyoung , Jun Ikhyun , Kim Tae-im , Seo Kyoung Yul , Kim Eung Kweon 
Published: June 2021

AbstractThis study evaluated the accuracy of total keratometry (TK) and standard keratometry (K) for intraocular lens (IOL) power calculation in eyes treated with femtosecond laser-assisted cataract surgery. The retrospective study included a retrospective analysis of data from 62 patients (91 eyes) who underwent uneventful femtosecond laser-assisted cataract surgery with Artis PL E (Cristalens Industrie, Lannion, France) IOL implantation by a single surgeon between May 2020 and December 2020 in Severance Hospital, Seoul, South Korea. The new IOLMaster 700 biometry device (Carl Zeiss Meditec, Jena, Germany) was used to calculate TK and K. The mean absolute error (MAE), median absolute error (MedAE), and the percentages of eyes within prediction errors of ± 0.25 D, ± 0.50 D, and ± 1.00 D were calculated for all IOL formulas (SRK/T, Hoffer-Q, Haigis, Holladay 1, Holladay 2, and Barrett Universal II). There was strong agreement between K and TK (intraclass correlation coefficient = 0.99), with a mean difference of 0.04 D. For all formulas, MAE tended to be lower for TK than for K, and relatively lower MAE and MedAE values were observed for SRK/T and Holladay 1. Furthermore, for all formulas, a greater proportion of eyes fell within ± 0.25 D of the predicted postoperative spherical equivalent range in the TK group than in the K group. However, differences in MAEs, MedAEs, and percentages of eyes within the above prediction errors were not statistically significant. In conclusion, TK and K exhibit comparable performance for refractive prediction in eyes undergoing femtosecond laser-assisted cataract surgery.
A predictive model for pain response following radiotherapy for treatment of spinal metastases
Authors: Wakabayashi Kohei , Koide Yutaro , Aoyama Takahiro , Shimizu Hidetoshi , Miyauchi Risei , Tanaka Hiroshi , Tachibana Hiroyuki , Nakamura Katsumasa , Kodaira Takeshi 
Published: June 2021

AbstractTo establish a predictive model for pain response following radiotherapy using a combination of radiomic and clinical features of spinal metastasis. This retrospective study enrolled patients with painful spine metastases who received palliative radiation therapy from 2018 to 2019. Pain response was defined using the International Consensus Criteria. The clinical and radiomic features were extracted from medical records and pre-treatment CT images. Feature selection was performed and a random forests ensemble learning method was used to build a predictive model. Area under the curve (AUC) was used as a predictive performance metric. 69 patients were enrolled with 48 patients showing a response. Random forest models built on the radiomic, clinical, and ‘combined’ features achieved an AUC of 0.824, 0.702, 0.848, respectively. The sensitivity and specificity of the combined features model were 85.4% and 76.2%, at the best diagnostic decision point. We built a pain response model in patients with spinal metastases using a combination of clinical and radiomic features. To the best of our knowledge, we are the first to examine pain response using pre-treatment CT radiomic features. Our model showed the potential to predict patients who respond to radiation therapy.
Three distinct atmospheric circulation patterns associated with high temperature extremes in South Korea
Authors: Kim Han-Kyoung , Moon Byung-Kwon , Kim Maeng-Ki , Park Jong-Yeon , Hyun Yu-Kyung 
Published: June 2021

AbstractThe negative impact of extreme high-temperature days (EHDs) on people’s livelihood has increased over the past decades. Therefore, an improved understanding of the fundamental mechanisms of EHDs is imperative to mitigate this impact. Herein, we classify the large-scale atmospheric circulation patterns associated with EHDs that occurred in South Korea from 1982 to 2018 using a self-organizing map (SOM) and investigate the dynamic mechanism for each cluster pattern through composite analysis. A common feature of all SOM clusters is the positive geopotential height (GPH) anomaly over the Korean Peninsula, which provides favorable conditions for EHDs through adiabatic warming caused by anomalous downward motion. Results show that Cluster 1 (C1) is related to the eastward-propagating wave train in the mid-latitude Northern Hemisphere, while Cluster 2 (C2) and 3 (C3) are influenced by a northward-propagating wave train forced by enhanced convection in the subtropical western North Pacific (WNP). Compared to C2, C3 exhibits strong and eastward-extended enhanced convection over the subtropical WNP, which generates an anomalous high-pressure system over the southern part of the Kamchatka Peninsula, reinforcing EHDs via atmospheric blocking. Our results can contribute to the understanding of East Asia climate variability because wave trains influence the climate dynamics of this region.
Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice
Authors: Chen Liuji , Na Ren , Danae McLane Kirsten , Thompson Cody Sylvester , Gao Ju , Wang Xinglong , Ran Qitao 
Published: June 2021

AbstractDegeneration and death of motor neurons in Amyotrophic Lateral Sclerosis (ALS) are associated with increased lipid peroxidation. Lipid peroxidation is the driver of ferroptosis, an iron-dependent oxidative mode of cell death. However, the importance of ferroptosis in motor neuron degeneration of ALS remains unclear. Glutathione peroxidase 4 (Gpx4) is a key enzyme in suppressing ferroptosis by reducing phospholipid hydroperoxides in membranes. To assess the effect of increased protection against ferroptosis on motor neuron disease, we generated SOD1G93AGPX4 double transgenic mice by cross-breeding GPX4 transgenic mice with SOD1G93A mice, a widely used ALS mouse model. Compared with control SOD1G93A mice, both male and female SOD1G93AGPX4 mice had extended lifespans. SOD1G93AGPX4 mice also showed delayed disease onset and increased motor function, which were correlated with ameliorated spinal motor neuron degeneration and reduced lipid peroxidation. Moreover, cell toxicity induced by SOD1G93A was ameliorated by Gpx4 overexpression and by chemical inhibitors of ferroptosis in vitro. We further found that the anti-ferroptosis defense system in spinal cord tissues of symptomatic SOD1G93A mice and sporadic ALS patients might be compromised due to deficiency of Gpx4. Thus, our results suggest that ferroptosis plays a key role in motor neuron degeneration of ALS.
Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
Authors: Hu Qing , Jiang Peipei , Feng Yongjing , Xu Yan , Zhou Nan , Chen Weibo , Zhu Li , Hu Yali , Zhou Zhengyang 
Published: June 2021

AbstractRecently, few noninvasive methods have been reported to evaluate endometrial fibrosis. Our study was to investigate the feasibility of intravoxel incoherent motion (IVIM) MR imaging in the detection of endometrial fibrosis in patients with intrauterine injury. 30 patients with hysteroscopy-confirmed endometrial fibrosis and 28 healthy women were enrolled to undergo MR examination including the IVIM sequence. Endometrial thickness (ET); apparent diffusion coefficient (ADC); and IVIM parameters, including pure diffusion coefficient (D), pseudodiffusion coefficient (D*) and vascular fraction (f) were evaluated. A multivariable model combing ADC, D, and f values using binary logistic regression analysis was built to diagnose endometrial fibrosis. Endometrial fibrosis patients demonstrated lower endometrial ADC, D, f values and ET (all p < 0.05). The multivariable model, ADC, D, f values and ET performed well in diagnosing endometrial fibrosis with AUC of 0.979, 0.965, 0.920, 0.901 and 0.833, respectively. The multivariable model revealed a better diagnostic accuracy than D, f and ET (all p < 0.05). Although ADC achieved a better diagnostic value than ET (z = 2.082, p < 0.05), no difference in AUC was shown among ADC, D, and f (all p > 0.05); between ET and D (p > 0.05); and between ET and f (p > 0.05). The reproducibility of ADC, D, f and D* values in patients with endometrial fibrosis and healthy women were good to excellent (ICC: 0.614–0.951). IVIM parameters exhibit promising potential to serve as imaging biomarkers in the noninvasive assessment of endometrial fibrosis.
Mixed convection flow along a curved surface in the presence of exothermic catalytic chemical reaction
Authors: Ahmad Uzma , Ashraf Muhammad , Abbas Amir , Rashad A. M. , Nabwey Hossam A. 
Published: June 2021

AbstractIn the current study, the attention is paid on the phenomena of mixed convection flow under the effect of exothermic catalytic chemical reaction along the curved surface. The proposed problem is modeled in nonlinear coupled partial differential equations. In keeping view the principle of homogeneity the dimensional flow model is transformed into dimensionless by using an appropriate scaling. This well arranged form of equations is then discretized with the aid of finite difference method for the numerical solution. The solutions of the considered model are estimated and displayed in the graphs. Here, in the contemporary study variables of physical significance such as velocity profile, temperature distribution and mass concentration are encountered efficiently. The incorporated pertinent dimensionless numbers that is body shape parameter, mixed convection parameter, modified mixed convection parameter, Prandtle number, exothermic parameter, chemical reaction parameter, temperature relative parameter, dimensionless activation energy parameter, and Schmidt number for which variations in the concentrated physical variables are estimated and presented in graphical way. For each boundary conditions computations are performed along the curved surface for different body shape parameter (n) values range from 0 up to 0.5; the obtained results satisfied by the boundary conditions. The velocity profile becomes increasingly more significant for n equal to 1 and due to the uniformly heated surface temperature profile and mass concentration are uniformly distributed.
Combination of 131I-trastuzumab and lanatoside C enhanced therapeutic efficacy in HER2 positive tumor model
Authors: Vinod Nagarajan , Kim Jae Hyung , Choi Seungbum , Lim Ilhan 
Published: June 2021

AbstractLanatoside C has a promising anti-tumor activity and is a potential candidate for radiosensitizers. In this study, we have investigated the therapeutic efficacy of the combination of 131I-trastuzumab and lanatoside C for inhibition of human epidermal growth factor receptor 2 (HER2) positive tumor progression in NCI-N87 xenograft model. The combination treatment (131I-trastuzumab and lanatoside C) showed highest cytotoxicity when compared to non-treated control or trastuzumab alone or 131I alone or 131I-trastuzumab alone in vitro. Biodistribution studies using 131I-trastuzumab or combination of 131I-trastuzumab and lanatoside C showed tumor uptake in BALB/c nude mice bearing HER2 positive NCI-N87 tumor xenograft model. The higher tumor uptake was observed in 131I-trastuzumab (19.40 ± 0.04% ID/g) than in the combination of 131I-trastuzumab and lanatoside C (14.02 ± 0.02% ID/g) at 24 h post-injection. Most importantly, an antitumor effect was observed in mice that received the combination of 131I-trastuzumab and lanatoside C (p = 0.009) when compared to control. In addition, mice received lanatoside C alone (p = 0.085) or 131I-trastuzumab alone (p = 0.160) did not significantly inhibit tumor progression compared with control. Taken together, our data suggest that combination of 131I-trastuzumab and lanatoside C might be a potential synergistic treatment for radioimmunotherapy to control the HER2 positive tumor.
Time‐frequency characterisation of bistatic Doppler signature of a wooded area walk at L‐band
Authors: Manfredi Giovanni , Hinostroza Sáenz Israel D. , Menelle Michel , Saillant Stéphane , Ovarlez Jean‐Philippe , Thirion‐Lefevre Laetitia 
Published: June 2021

AbstractThe Doppler signature of a man walking in a forested area analysed at L‐band is presented here. The aim is twofold: to assess the best time‐frequency distribution to characterise the activity; to highlight the similarity of the simulated data to the measured ones to validate the simulation tool. Indeed, the Doppler‐Time (DT) signal variation represents the main characteristic of Artificial Neural Networks (ANNs) for classification. The more accurately the DT characterises the activity, the higher the machine’s accuracy in classifying it. Besides, in the training data frame, reliable simulated models may supply the amount of data needed by ANN applications. Thus, a short‐time Fourier transform (STFT), a reassigned spectrogram (RE‐Spect), and a pseudo‐Wigner–Ville distribution have been applied to the measured and simulated data. The measurements have been performed using a bistatic radar working at 1 GHz. Then, the measurement setup has been replicated in simulation, and 3‐D human bodies walking in free space have been computed using physical optics. The results show that the STFT is the most suitable time‐frequency method for recognising and classifying the walk. Moreover, the simulated data are in agreement with the measured data, regardless of the chosen Cohen’s technique.
Drifting features: Detection and evaluation in the context of automatic RR Lyrae identification in the VVV
Authors: Cabral J. B. , Lares M. , Gurovich S. , Minniti D. , Granitto P. M. 
Published: June 2021

Context. As most of the modern astronomical sky surveys produce data faster than humans can analyse it, machine learning (ML) has become a central tool in astronomy. Modern ML methods can be characterised as highly resistant to some experimental errors. However, small changes in the data over long angular distances or long periods of time, which cannot be easily detected by statistical methods, can be detrimental to these methods.
Aims. We develop a new strategy to cope with this problem, using ML methods in an innovative way to identify these potentially detrimental features.
Methods. We introduce and discuss the notion of drifting features, related with small changes in the properties as measured in the data features. We use the identification techniques of RR Lyrae variable objects (RRLs) in the VVV based on an earlier work and introduce a method for detecting drifting features. For the VVV, each sky observation zone is called a tile. Our method forces the classifier to learn from the sources (mostly stellar ‘point sources’) which tile the source originated from and to select the features that are most relevant to the task of finding candidate drifting features.
Results. We show that this method can efficiently identify a reduced set of features that contains useful information about the tile of origin of the sources. For our particular example of detecting RRLs in the VVV, we find that drifting features are mostly related to colour indices. On the other hand, we show that even if we have a clear set of drifting features in our problem, they are mostly insensitive to the identification of RRLs.
Conclusions. Drifting features can be efficiently identified using ML methods. However, in our example removing drifting features does not improve the identification of RRLs.
Methodology for creating a residential three-rayed space-planning structure
Authors: Nureyev Tagir , Popov Anton 
Published: June 2021

Problem statement. The purpose of this study is to create a methodology for designing a residential three-rayed space-planning structure for small and medium-rise buildings. The methodology was created for the central and southern insolation zones of Russia in the conditions of sanitary standards of 2017. The methodology is applicable in countries located in both hemispheres of our planet with mirrored conditions of the Russian insolation standards.
Results. A methodology has been developed that creates many types of «daughter» residential sections based on a single «T-shaped» three-rayed residential section, which is called the «maternal». The applied result of the research was of 27 planimetric methods of architectural combinatorics and kinetics, as well as two patents. The presented methods are implemented in brick structures during the reconstruction of the residential quarter No. 75 in the historical center of the Russian city of Menzelinsk in the Republic of Tatarstan.
Conclusions. The significance of the results obtained for architecture lies in energy-efficient design, expressed in a reduction design time and an increase the types of «daughter» residential sections. The methodology was created for the future computer program for the design of multi-rayed structures of residential buildings of various storeys.
Zusammenfluss statt Ausschluss
Authors: Bögel-Witt Martina 
Published: June 2021

SummaryFülle und Leere beziehungsweise Mangel gehören als Gegensatzpaar zu den acht Leitkriterien der TCM-Diagnostik und -Therapie. Wie alle Leitkriterien wurzeln auch sie im Grundprinzip von Yin und Yang. Unterschieden werden in der Praxis Yang-Fülle, Yang-Mangel, Yin-Fülle und Yin-Mangel. Der Beitrag zeigt exemplarisch diagnostische Besonderheiten und therapeutische Möglichkeiten. Wichtig für die Therapie ist zu unterscheiden, ob es sich um einen echten oder falschen beziehungsweise relativen Fülle- oder Mangelzustand handelt.
Religiosität und Spiritualität als Ressourcen in der Betreuung von Patienten mit Kopf-Hals-Tumoren
Authors: Vitek Petr , Koscielny Sven , Büssing Arndt , Hübner Jutta , Büntzel Jens 
Published: June 2021

Zusammenfassung
Fragestellung Spiritual Care ist ein etablierter Bestandteil einer ganzheitlichen Betreuung in der Palliativmedizin. Stellen Religiosität und Spiritualität auch eine Ressource in früheren Phasen der Erkrankung von Kopf-Hals-Tumorpatienten (KHT) dar?
Material und Methode An der prospektiven Studie nahmen 113 KHT-Patienten (27 Frauen, 84 Männer, 2 divers) teil. Der Fragebogen erfasste die momentane Belastungssituation (NRS), Spiritualität als Ressource (SpREUK-15), spirituelle Bedürfnisse (SpNQ-20), Krankheitsinterpretationen (IIQ) sowie die Lebenszufriedenheit der Patienten (BMLSS-10, BMLSS-Support, WHO-5). 39 Patienten befanden sich aktuell in Therapie, 74 in Langzeitbetreuung.
Ergebnisse Nur 31/111 (28 %) Patienten empfinden sich als religiös und/oder spirituell, 72 % als weder religiös noch spirituell. 51/111 Teilnehmer erkennen in der Reflexion über ihre Erkrankung eine Teil-Ressource zur Bewältigung der Lebenssituation. An spirituellen Bedürfnissen beschreiben sie: religiöse 35/112, existenzielle 67/112, innerer Frieden 90/112, Generativität 84/112. Neben der eigenen Religiosität ist das Stadium der Erkrankung eine Einflussgröße auf spirituelle Bedürfnisse und Ressourcen. Patienten mit Kopf-Hals-Tumoren neigen zu depressiven Verstimmungen (WHO-5 ≤ 50 %) und sind mit ihrer Lebens- und Unterstützungssituation tendenziell unzufrieden.
Schlussfolgerung 60–90 % der Kopf-Hals-Tumorpatienten haben spezifische spirituelle Bedürfnisse, die aber nicht immer erkannt werden. Moderne Konzepte integrativer Onkologie nehmen diese auf und stärken über diese Ressourcen die Lebensqualität und das Coping der Betroffenen.
Treatment of Primary Shoulder Stiffness: Results of a Survey on Surgeon Practice Patterns in Italy
Authors: Cucchi Davide , De Giorgi Silvana , Saccomanno Maristella F. , Uboldi Francesco , Menon Alessandra , Friedrich Max J. , Walter Sebastian G. , de Girolamo Laura 
Published: June 2021

Abstract
Objectives Shoulder stiffness is a condition of restricted glenohumeral range of motion (ROM), which can arise spontaneously or as consequence of a known cause. Several treatment options are available and currently no consensus has been obtained on which treatment algorithm represents the best choice for the patient. The aim of this study was to investigate surgeon practice patterns in Italy regarding treatment of primary shoulder stiffness.
Methods A literature review was performed to identify randomized controlled trials reporting results of shoulder stiffness treatment. The following controversial or critical points in the treatment of primary shoulder stiffness were identified: modalities of physical therapy; indication for oral corticosteroid; indication and frequency for injective corticosteroid; technique and site of injection; and indication, timing, and technique for surgery. A survey composed by 14 questions was created and administrated to the members of a national association specialized in orthopaedics and sports traumatology (SIGASCOT at the time of survey completion, recently renamed SIAGASCOT after the fusion of the societies SIGASCOT and SIA).
Results A total of 204 completed questionnaires were collected. Physical therapy was recommended by 98% of the interviewed. The use of oral corticosteroids was considered by 51%, and injections of corticosteroids by 72%. The posterior injection approach was the one preferred and a number of three was considered the upper limit for repeated injections. Injective therapy with local anesthetics and hyaluronic acid was considered by more than 20% of the interviewed. Thirty percent of the interviewed did not treat shoulder stiffness surgically.
Conclusion Several approaches to shoulder stiffness have been proposed and high-level evidence is available to analyze and discuss their results. Several controversial points emerged both from a literature review and from this national survey. Treatment of shoulder stiffness should be tailored to the patient's clinical situation and the stage of its pathology and should aim at pain reduction, ROM restoration, functional regain, and shortening of symptoms duration, with conservative therapy remaining the mainstay of treatment.
Subchondroplasty in the Treatment of Bone Marrow Lesions of the Knee: Preliminary Experience on First 15 Patients
Authors: Pasqualotto Stefano , Sgroi Andrea Vincenzo , Causero Araldo , Di Benedetto Paolo , Zorzi Claudio 
Published: June 2021

AbstractPurpose The aim of this prospective study was to assess the effectiveness in terms of pain relief and functional improvement of the Subchondroplasty procedure in the treatment of osteoarthritis-related bone marrow lesions (BMLs) of the knee.Methods The study included first 15 consecutive patients undergone to Subchondroplasty procedure for the treatment of chronic degenerative BMLs in which previous conservative treatment have failed. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, Knee Injury and Osteoarthritis Outcome Scores (KOOS), and visual analog scale (VAS) pain scores were obtained preoperatively and at 1, 6, and 12 months of follow-up.Results WOMAC scores significantly improved from 39.7 ± 20.2 before surgery to 26.8 ± 16.1 at the 1-month follow-up (p = 0.045). A further significant improvement to 15.5 ± 12.7 (p = 0.02) and to 8.6 ± 3.1 (p < 0.01) was obtained both at 6-month and at 1-year follow-up. KOOS scores improved significantly from 47.5 ± 16.6 before surgery to 65.4 ± 14.9 at 1 month (p = 0.013) and to 80.4 ± 15.1 at 6-month follow-up (p = 0.01). A further improvement to 85.6 ± 15.1 was recorded 1 year postoperatively, although nonsignificant. VAS score showed a significant improvement from 55.8 ± 20.5 preoperatively to 36.2 ± 16.9 at 1 month (p = 0.008) and to 18.2 ± 17.3 at 6-month follow-up (p = 0.005). This further improved to 12.8 ± 17.9 at 1-year follow-up, although not significantly.Conclusion Subchondroplasty procedure represents a safe and valid surgical option in the treatment of osteoarthritis-related BMLs of the knee, providing an improvement in terms of pain relief and functional recovery. Longer studies are required to evaluate how long these improvements may last.Level of Evidence Therapeutic case-series, Level IV study.