bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Employment Status, Reported Physical Activity, and Sitting Time During COVID-19 Pandemic
Authors: Lindsey Bryndan W. , Boolani Ali , Merrigan Justin J. , Cortes Nelson , Caswell Shane V. , Martin Joel R. 
Published: February 2021

Background: The COVID-19 pandemic has changed our working environment and divided workers into essential or nonessential statuses. Employment status is a major factor determining the amount of physical activity performed. Our purpose was to understand how employment status affects physical activity and sitting time. Methods: Between April 13 and May 4, 2020, 735 full-time employed individuals responded to a survey investigating daily life and overall health during the COVID-19 pandemic. Participants reported how much physical activity they had performed in the last 7 days. Multiple linear regressions were performed for physical activity and sitting time. Results: Physical activity was not associated with employment status. An interaction effect between hours worked and employment status was found for sitting time. Conclusions: Employment status was not related to physical activity; however, it did affect the amount of time spent sitting, with nonessential employees sitting more and working more hours than essential employees. Because greater amounts of daily total sitting time have been associated with increased risk of all-cause mortality, it is important that increased sitting time be attenuated by greater physical activity.
Dematiaceous fungal invasion of a bandage contact lens
Authors: Dutta Anirban , Das Sujata , Behera Himanshu Sekhara , Mittal Ruchi 
Published: February 2021

A 61-year-old man presented with a 1-month history of reduced vision, redness and pain in the right eye. Examination revealed a bandage contact lens (BCL) in situ with diffuse, pigmented deposits. On removal, the underlying cornea was found to be clear. He had been prescribed the BCL 6 months ago following a deep-seated corneal foreign body removal and was unable to follow-up subsequently.The BCL was sent for microbiological and histopathological evaluation. The culture revealed growth ofCladosporiumspp, a dematiaceous fungi. Periodic acid–Schiff staining revealed infiltration of pigmented fungal filaments into the substance of the BCL.While contact lens deposits are a frequent finding, fungal deposits are seldom noted. Irregular follow-up and improper lens maintenance are significant risk factors for the same. Early identification and subsequent removal of the lens is vital to prevent infection of the underlying ocular structures.
Pre-Descemet’s endothelial keratoplasty: a simple, Descemet’s membrane scoring technique for successful graft preparation
Authors: Pereira Nicolas Cesario , Forseto Adriana dos Santos , Maluf Rafaela Cesario Pereira , Dua Harminder Singh 
Published: February 2021

PurposePre-Descemet’s endothelial keratoplasty (PDEK) donor tissue preparation involves the intrastromal injection of air to create a type 1 big bubble (BB) and avoidance of the creation of a type 2 BB. The purpose of this study was to design and test a technique to consistently creates a type 1 BB without risk of creating a type 2 BB.MethodsA prospective matched study with 64 human donor sclerocorneal discs, which were not suitable for corneal transplantation, was conducted. The corneas were divided into two groups, of which 32 were subjected to the standard technique of preparing the PDEK donor tissue (group 1, control) and 32 new technique, where in the donor Descemet’s membrane was scored with a Sinskey hook. Frequency of occurrence of different types of BB was compared and statistically analysed.ResultsWith the standard technique (group 1), type 1 BB occurred in 53.1%, type 2 BB in 34.4% and mixed BB in 12.5% of samples. With the scoring technique (group 2), a type 1 BB occurred in 100% of the samples. No type 2 or mixed BB occurred in any case in group 2. The difference in creation of a type 1BB between the two groups was statistically significant (p=0.00).ConclusionThe scoring technique is a simple, inexpensive and reproducible option to consistently achieve a type 1 BB to prepare PDEK graft tissue. The next step would be to study the clinical outcomes of PDEK performed with tissue obtained by the scoring technique.
Pre-flight exercise and bone metabolism predict unloading-induced bone loss due to spaceflight
Authors: Gabel Leigh , Liphardt Anna-Maria , Hulme Paul A , Heer Martina , Zwart Sara R , Sibonga Jean D , Smith Scott M , Boyd Steven K 
Published: February 2021

ObjectivesBone loss remains a primary health concern for astronauts, despite in-flight exercise. We examined changes in bone microarchitecture, density and strength before and after long-duration spaceflight in relation to biochemical markers of bone turnover and exercise.MethodsSeventeen astronauts had their distal tibiae and radii imaged before and after space missions to the International Space Station using high-resolution peripheral quantitative CT. We estimated bone strength using finite element analysis and acquired blood and urine biochemical markers of bone turnover before, during and after spaceflight. Pre-flight exercise history and in-flight exercise logs were obtained. Mixed effects models examined changes in bone and biochemical variables and their relationship with mission duration and exercise.ResultsAt the distal tibia, median cumulative losses after spaceflight were −2.9% to −4.3% for bone strength and total volumetric bone mineral density (vBMD) and −0.8% to −2.6% for trabecular vBMD, bone volume fraction, thickness and cortical vBMD. Mission duration (range 3.5–7 months) significantly predicted bone loss and crewmembers with higher concentrations of biomarkers of bone turnover before spaceflight experienced greater losses in tibia bone strength and density. Lower body resistance training volume (repetitions per week) increased 3–6 times in-flight compared with pre-spaceflight. Increases in training volume predicted preservation of tibia bone strength and trabecular vBMD and thickness.ConclusionsFindings highlight the fundamental relationship between mission duration and bone loss. Pre-flight markers of bone turnover and exercise history may identify crewmembers at greatest risk of bone loss due to unloading and may focus preventative measures.
Sickle cell disease in India: a scoping review from a health systems perspective to identify an agenda for research and action
Authors: Raman Vineet , Seshadri Tanya , Joice Sangeetha V , N Srinivas Prashanth 
Published: February 2021

IntroductionSickle cell disease (SCD) disproportionately impacts Adivasi (tribal) communities in India. Current research has focused on epidemiological and biomedical aspects but there has been scarce research on social determinants and health systems aspects. Given its fragmented distribution, resources and programmes have emerged in west and central India. This scoping review seeks to identify geographical and evidence gaps for action on SCD from a health systems lens.MethodsWe followed a scoping review protocol, using Google Scholar and PubMed for published literature. Keywords used included sickle cell anaemia/disease, health systems, tribal and India. We used Google search for grey literature. We compiled a list of 55 records (of which 35 were retained), with about half pertaining directly to India and others relevant to similar settings. Results were organised and analysed using the WHO health systems framework to identify geographical and evidence gaps.ResultsWe found substantial literature on biomedical and clinical aspects of SCD but little on the design and implementation of programmes in community and Adivasi-specific contexts as well as on social determinants of SCD. There were regional gaps in knowledge in southern and northeast India. Wherever community-based programmes exist, they have originated in civil society initiatives and relatively limited state-led primary healthcare-based efforts pointing to weak agenda setting.ConclusionBoth research and action on SCD especially among tribal populations need immediate attention. While geospatial epidemiology has been well understood, gaps remain in context-specific knowledge for action in several parts, as well as evidence gaps across several health system building blocks, including governance and financing of care. Despite publication of a draft policy, delayed adoption and lapses in implementation have limited the response largely to local communities and non-governmental organisations.
Pseudo-safety in a cohort of patients with COVID-19 discharged home from the emergency department
Authors: Yuan Neal , Ji Hongwei , Sun Nancy , Botting Patrick , Nguyen Trevor , Torbati Sam , Cheng Susan , Ebinger Joseph 
Published: February 2021

IntroductionEDs are often the first line of contact with individuals infected with COVID-19 and play a key role in triage. However, there is currently little specific guidance for deciding when patients with COVID-19 require hospitalisation and when they may be safely observed as an outpatient.MethodsIn this retrospective study, we characterised all patients with COVID-19 discharged home from EDs in our US multisite healthcare system from March 2020 to August 2020, focusing on individuals who returned within 2 weeks and required hospital admission. We restricted analyses to first-encounter data that do not depend on laboratory or imaging diagnostics in order to inform point-of-care assessments in resource-limited environments. Vitals and comorbidities were extracted from the electronic health record. We performed ordinal logistic regression analyses to identify predictors of inpatient admission, intensive care and intubation.ResultsOf n=923 patients who were COVID-19 positive discharged from the ED, n=107 (11.6%) returned within 2 weeks and were admitted. In a multivariable-adjusted model including n=788 patients with complete risk factor information, history of hypertension increased odds of hospitalisation and severe illness by 1.92-fold (95% CI 1.07 to 3.41), diabetes by 2.20-fold (1.18 to 4.02), chronic lung disease by 2.21-fold (1.22 to 3.92) and fever by 2.89-fold (1.71 to 4.82). Having at least two of these risk factors increased the odds of future hospitalisation by 6.68-fold (3.54 to 12.70). Patients with hypertension, diabetes, chronic lung disease or fever had significantly longer hospital stays (median 5.92 days, 3.08–10.95 vs 3.21, 1.10–5.75, p<0.01) with numerically higher but not significantly different rates of intensive care unit admission (27.02% vs 14.30%, p=0.27) and intubation (12.16% vs 7.14%, p=0.71).DiscussionPatients infected with COVID-19 may appear clinically safe for home convalescence. However, those with hypertension, diabetes, chronic lung disease and fever may in fact be only ‘pseudo-safe’ and are most at risk for subsequent hospitalisation with more severe illness and longer hospital stays.
Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances
Authors: Liu Yi , Bi Taiyong , Zhang Bei , Kuang Qijie , Li Haijing , Zong Kunlun , Zhao Jingping , Ning Yuping , She Shenglin , Zheng Yingjun 
Published: February 2021

BackgroundWorking memory (WM) deficit is considered a core feature and cognitive biomarker in patients with schizophrenia. Several studies have reported prominent object WM deficits in patients with schizophrenia, suggesting that visual WM in these patients extends to non-spatial domains. However, whether non-spatial WM is similarly affected remains unclear.AimThis study primarily aimed to identify the processing of visual object WM in patients with first-episode schizophrenia.MethodsThe study included 36 patients with first-episode schizophrenia and 35 healthy controls. Visual object WM capacity, including face and house WM capacity, was assessed by means of delayed matching-to-sample visual WM tasks, in which participants must distribute memory so that they can discriminate a target sample. We specifically examined their anhedonia experience by the Temporal Experience of Pleasure Scale and the Snaith-Hamilton Pleasure Scale. Cognitive performance was measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).ResultsBoth face and house WM capacity was significantly impaired in patients with schizophrenia. For both tasks, the performance of all the subjects was worse under the high-load condition than under the low-load condition. We found that WM capacity was highly positively correlated with the performance on RBANS total scores (r=−0.528, p=0.005), RBANS delayed memory scores (r=−0.470, p=0.013), RBANS attention scores (r=−0.584, p=0.001), RBANS language scores (r=−0.448, p=0.019), Trail-Making Test: Part A raw scores (r=0.465, p=0.015) and simple IQ total scores (r=−0.538, p=0.005), and correlated with scores of the vocabulary test (r=−0.490, p=0.011) and scores of the Block Diagram Test (r=−0.426, p=0.027) in schizophrenia. No significant correlations were observed between WM capacity and Positive and Negative Syndrome Scale symptoms.ConclusionsOur research found that visual object WM capacity is dramatically impaired in patients with schizophrenia and is strongly correlated with other measures of cognition, suggesting a mechanism that is critical in explaining a portion of the broad cognitive deficits observed in schizophrenia.
Safety and efficacy of hydrothermal duodenal mucosal resurfacing in patients with type 2 diabetes: the randomised, double-blind, sham-controlled, multicentre REVITA-2 feasibility trial
Authors: Mingrone Geltrude , van Baar Annieke CG , Devière Jacques , Hopkins David , Moura Eduardo , Cercato Cintia , Rajagopalan Harith , Lopez-Talavera Juan Carlos , White Kelly , Bhambhani Vijeta , Costamagna Guido , Haidry Rehan , Grecco Eduardo , Galvao Neto Manoel , Aithal Guruprasad , Repici Alessandro , Hayee Bu'Hussain , Haji Amyn , Morris A John , Bisschops Raf , Chouhan Manil D , Sakai Naomi S , Bhatt Deepak L , Sanyal Arun J , Bergman J J G H M 
Published: February 2021

ObjectiveHydrothermal duodenal mucosal resurfacing (DMR) is a safe, outpatient endoscopic procedure. REVITA-2, a double-blind, superiority randomised controlled trial, investigates safety and efficacy of DMR using the single catheter Revita system (Revita DMR (catheter and system)), on glycaemic control and liver fat content in type 2 diabetes (T2D).DesignEligible patients (haemoglobin A1c (HbA1c) 59–86 mmol/mol, body mass index≥24 and ≤40 kg/m2, fasting insulin >48.6 pmol/L, ≥1 oral antidiabetic medication) enrolled in Europe and Brazil. Primary endpoints were safety, change from baseline in HbA1c at 24 weeks, and liver MRI proton-density fat fraction (MRI-PDFF) at 12 weeks.ResultsOverall mITT (DMR n=56; sham n=52), 24 weeks post DMR, median (IQR) HbA1c change was −10.4 (18.6) mmol/mol in DMR group versus −7.1 (16.4) mmol/mol in sham group (p=0.147). In patients with baseline liver MRI-PDFF >5% (DMR n=48; sham n=43), 12-week post-DMR liver-fat change was −5.4 (5.6)% in DMR group versus −2.9 (6.2)% in sham group (p=0.096). Results from prespecified interaction testing and clinical parameter assessment showed heterogeneity between European (DMR n=39; sham n=37) and Brazilian (DMR n=17; sham n=16) populations (p=0.063); therefore, results were stratified by region. In European mITT, 24 weeks post DMR, median (IQR) HbA1c change was –6.6 mmol/mol (17.5 mmol/mol) versus –3.3 mmol/mol (10.9 mmol/mol) post-sham (p=0.033); 12-week post-DMR liver-fat change was –5.4% (6.1%) versus –2.2% (4.3%) post-sham (p=0.035). Brazilian mITT results trended towards DMR benefit in HbA1c, but not liver fat, in context of a large sham effect. In overall PP, patients with high baseline fasting plasma glucose ((FPG)≥10 mmol/L) had significantly greater reductions in HbA1c post-DMR versus sham (p=0.002). Most adverse events were mild and transient.ConclusionsDMR is safe and exerts beneficial disease-modifying metabolic effects in T2D with or without non-alcoholic liver disease, particularly in patients with high FPG.Trial registration numberNCT02879383
Real-world survival outcomes with immune checkpoint inhibitors in large-cell neuroendocrine tumors of lung
Authors: Dudnik Elizabeth , Kareff Samuel , Moskovitz Mor , Kim Chul , Liu Stephen V , Lobachov Anastasiya , Gottfried Teodor , Urban Damien , Zer Alona , Rotem Ofer , Onn Amir , Wollner Mira , Bar Jair 
Published: February 2021

BackgroundLittle is known regarding the efficacy of immune checkpoint inhibitors (ICI) in patients with advanced large-cell neuroendocrine lung carcinoma (aLCNEC).Methods125 consecutive patients with aLCNEC were identified in the electronic databases of 4 participating cancer centers. The patients were divided into group A (patients who received ICI, n=41) and group B (patients who did not receive ICI, n=84). Overall survival since advanced disease diagnosis (OS DX) and OS since ICI initiation (OS ICI) were captured.ResultsWith a median follow-up of 11.8 months (mo) (IQR 7.5–17.9) and 6.0mo (IQR 3.1–10.9), 66% and 76% of patients died in groups A and B, respectively. Median OS DX was 12.4mo (95% CI 10.7 to 23.4) and 6.0mo (95% CI 4.7 to 9.4) in groups A and B, respectively (log-rank test, p=0.02). For ICI administration, HR for OS DX was 0.59 (95% CI 0.38 to 0.93, p=0.02—unadjusted), and 0.58 (95% CI 0.34 to 0.98, p=0.04—adjusted for age, Eastern Cooperative Oncology Group (ECOG) performance status (PS), presence of liver metastases and chemotherapy administration). In a propensity score matching analysis (n=74; 37 patients in each group matched for age and ECOG PS), median OS DX was 12.5 mo (95% CI 10.6 to 25.2) and 8.4 mo (95% CI 5.4 to 16.9) in matched groups A and B, respectively (log-rank test, p=0.046). OS ICI for patients receiving ICI as monotherapy (n=36) was 11.0 mo (95% CI 6.1 to 19.4).ConclusionsWith the limitations of retrospective design and small sample size, the results of this real-world cohort analysis suggest a positive impact of ICI on OS in aLCNEC.
Wheat straw and biochar effect on soil carbon fractions, enzyme activities, and nutrients in a tobacco field
Authors: Wang Yi , Dong Jianxin , Zheng Xuebo , Zhang Jiguang , Zhou Peilu , Song Xiaopei , Song Wenjing , Wang Shusheng 
Published: February 2021

Annual removal of tobacco residues and insufficient input of organic materials have exacerbated total organic carbon (TOC) depletion and soil degradation in a tobacco field in the Huanghuai area. Straw residue and biochar application may be effective ways to increase TOC accumulation and improve soil fertility. In this field experiment, wheat straw (WS) and wheat-straw-derived biochar (BC) with mineral fertilizer were compared with mineral fertilizer alone (CK), and we assessed their effects on soil organic carbon fractions, enzyme activities, and nutrients in Shandong Province, China, during 2016 and 2017. At 0–20 cm depth, the WS treatment had a greater overall effect on the measured soil properties. Compared with the control, the WS treatment significantly increased the concentrations of microbial biomass carbon (MBC), hot-water-extractable carbon (HWC), and permanganate-oxidizable carbon concentrations (POXC; by 252.41%, 107.02%, and 65.53%, respectively); the activities of sucrase, urease, and phosphatase (by 112.52%, 7.81%, and 34.33%, respectively); and the contents of alkaline hydrolysable nitrogen, available phosphorus, and available potassium (by 92.22%, 100.78%, and 10.57%, respectively). Compared with the control, the BC treatment significantly increased TOC content, MBC content, light fraction organic carbon (LFOC), and potassium (TK) concentration (by 74.93%, 86.24%, 153.73%, and 21.92%, respectively). Most soil enzyme activity and nutrient parameters were significantly correlated with MBC. Thus, straw application improved soil fertility by increasing the concentrations of high labile organic carbon fractions (HWC, MBC, and POXC), stimulating soil enzyme activities, and releasing more soil available nutrients, and BC addition contributed to the accumulation of TOC, MBC, LFOC, and TK.
Thermal study of a coupled-channel system: a brief review
Authors: Lo Pok Man 
Published: February 2021

AbstractWe demonstrate the construction of a density of states from the S-matrix describing a coupled-channel (S-wave $$\pi \pi , K {\bar{K}}$$

π
π
,
K

K

¯

) system, and examine the influences from various structures of particle dynamics: poles, roots, and Riemann sheets.
Explaining muon $${g}-2$$ data in the $$\mu \nu $$SSM
Authors: Kpatcha Essodjolo , Lara Iñaki , López-Fogliani Daniel E. , Muñoz Carlos , Nagata Natsumi 
Published: February 2021

AbstractWe analyze the anomalous magnetic moment of the muon $$g-2$$

g
-
2

in the $$\mu \nu $$

μ
ν

SSM. This R-parity violating model solves the $$\mu $$
μ
problem reproducing simultaneously neutrino data, only with the addition of right-handed neutrinos. In the framework of the $$\mu \nu $$

μ
ν

SSM, light left muon-sneutrino and wino masses can be naturally obtained driven by neutrino physics. This produces an increase of the dominant chargino-sneutrino loop contribution to muon $$g-2$$

g
-
2

, solving the gap between the theoretical computation and the experimental data. To analyze the parameter space, we sample the $$\mu \nu $$

μ
ν

SSM using a likelihood data-driven method, paying special attention to reproduce the current experimental data on neutrino and Higgs physics, as well as flavor observables such as B and $$\mu $$
μ
decays. We then apply the constraints from LHC searches for events with multi-leptons + MET on the viable regions found. They can probe these regions through chargino–chargino, chargino–neutralino and neutralino–neutralino pair production. We conclude that significant regions of the parameter space of the $$\mu \nu \mathrm{SSM}$$

μ
ν
SSM

can explain muon $$g-2$$

g
-
2

data.
Quasinormal modes of hot, cold and bald Einstein–Maxwell-scalar black holes
Authors: Blázquez-Salcedo Jose Luis , Herdeiro Carlos A. R. , Kahlen Sarah , Kunz Jutta , Pombo Alexandre M. , Radu Eugen 
Published: February 2021

AbstractEinstein–Maxwell-scalar models allow for different classes of black hole solutions, depending on the non-minimal coupling function $$f(\phi )$$

f
(
ϕ
)

employed, between the scalar field and the Maxwell invariant. Here, we address the linear mode stability of the black hole solutions obtained recently for a quartic coupling function, $$f(\phi )=1+\alpha \phi ^4$$

f

(
ϕ
)

=
1
+
α

ϕ
4

(Blázquez-Salcedo et al. in Phys. Lett. B 806:135493, 2020). Besides the bald Reissner–Nordström solutions, this coupling allows for two branches of scalarized black holes, termed cold and hot, respectively. For these three branches of black holes we calculate the spectrum of quasinormal modes. It consists of polar scalar-led modes, polar and axial electromagnetic-led modes, and polar and axial gravitational-led modes. We demonstrate that the only unstable mode present is the radial scalar-led mode of the cold branch. Consequently, the bald Reissner–Nordström branch and the hot scalarized branch are both mode-stable. The non-trivial scalar field in the scalarized background solutions leads to the breaking of the degeneracy between axial and polar modes present for Reissner–Nordström solutions. This isospectrality is only slightly broken on the cold branch, but it is strongly broken on the hot branch.