bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of electric cardioversion on platelet activation
Authors: Haidl Harald , Gaugler Johanna , Cvirn Gerhard , Jasser-Nitsche Hildegard , Schwinger Wolfgang , Pohl Sina , Bisping Egbert , Gallistl Siegfried , Schlagenhauf Axel 
Published: April 2021

Introduction
Atrial fibrillation (AF) comes along with high risk of stroke. This risk continues even after re-establishing sinus rhythm with cardioversion. Aim of this study is to evaluate the contribution of electric cardioversion (EC) to platelet activation and procoagulatory tendency.

Methods
Extent of platelet activation before and after electric cardioversion was quantified using flow cytometry, impedance aggregation measurements with Multiplate®, and quantification of serum levels of platelet factor 4 (PF4) and ß-thromboglobulin (ß-TG) in patients with AF (N = 10).

Results
No significant differences were observed in any of the measured parameters comparing the values from before and after cardioversion. Geometric means of P-selectin expression and integrin αIIbβ3 activation were 0.27 (+/- 0.07) and 2.30 (+/- 2.61) before EC and 0.28 (+/- 0.17) and 1.67 (+/- 1.82) after EC. Levels of ß-TG were 110.11 ng/ml (+/- 3.78) before and 110.51 ng/ml (+/- 2.56) after EC, levels of PF4 were 35.64 ng/ml (+/- 12.94) before and 32.40 ng/ml (+/- 4.95) after EC. Platelet aggregation triggered with adenosine diphosphate (ADP), arachidonic acid, collagen, Ristocetin, or thrombin receptor activating peptide (TRAP) revealed results within the normally expected ranges without significant changes before and after EC.

Discussion
Electric cardioversion has no influence on platelet activation markers which is in agreement with other studies reporting electrical cardioversion to be safe.
An Embodied Existence in Heaven and the Non-Cartesian Substance Dualism
Authors: Perez Alejandro 
Published: April 2021

In this paper, I propose to imagine, through Non–Cartesian substance dualism (NCSD), how we could resurrect. Even though many objections have been addressed to the classic conception of eschatology since the beginning of the century of eschatology, I propose we have some reasons to think that a more corporeal conception of the eschaton is not only desirable but also metaphysically possible and compatible with biblical data. I shall explore what I call the Christ Body Argument, which invites us to reject, on the one hand, a disembodied existence in heaven, and on the other side to adopt a corporeal existence of Christ in heaven. A kind of Dualism, and more precisely, one possessing NCSD’s virtues, could play a role in exploring this new theological option. I expect to show that NCSD is a metaphysical option allowing us to understand better what we are. If we hope and believe in the resurrection of the dead, NCSD provides an interesting model to think about it.
Crystal structure of N′,N‴-((propane-2,2-diylbis(1H-pyrrole-5,2-diyl))bis(methaneylylidene))-di(isonicotinohydrazide)– water – dimethylformamide (1/4/2), C25H24N8O2·4H2O·2C3H7NO
Authors: Xiong Ying , An Ya 
Published: April 2021

Abstract
C31H46N10O8, monoclinic, P2/n (no. 13), a = 8.8207(6) Å, b = 9.7818(8) Å, c = 20.9498(17) Å, β = 97.259(3)°, V = 1793.1(2) Å3, Z = 2, R

gt
(F) = 0.0426, wR

ref
(F
2) = 0.1269, T = 273 K.
Chromium oxide pigments
Authors: Pfaff Gerhard 
Published: April 2021

Abstract
The chromium(III) oxide pigments Cr2O3 (chromium oxide green) and CrOOH (chromium oxide hydrate green) are representatives of the inorganic green and blue–green pigments. Cr2O3 pigments are very important for the coloration of paints, coatings, plastics, building materials and other application systems. CrOOH pigments have lost their technical importance because of the low thermal stability. Chromium oxide green pigments are characterized by excellent application properties. They are synthesized starting from alkali dichromates or ammonium dichromate by reduction in liquid or solid phase.
Iron blue pigments
Authors: Pfaff Gerhard 
Published: April 2021

Abstract
Iron blue pigments are representatives of the inorganic blue pigments. They are characterized by a sufficient hue, high tinting strength, and suitable rheological properties. Iron blue pigments are subdivided into “soluble iron blue” and “insoluble iron blue”. Both pigments are synthesized using precipitation techniques. Iron blue pigments are mainly used in printing applications. Special uses of the pigments are agriculture and medicine.
Oxonitride pigments
Authors: Pfaff Gerhard 
Published: April 2021

Abstract
Oxonitride pigments belong to the inorganic yellow, orange and red colorants. They were developed to complement the yellow, orange and red color range. Oxonitride compositions that are interesting for pigment uses crystallize in perovskite, chalcolamprite and spinel structures. The most suitable compositions for pigment purposes are most probably LaTaON2 and CaTaO2N. The synthesis of oxonitride pigments is technically difficult and takes place using a solid state-gas reaction. The pigments are characterized by excellent optical and application characteristics in particular regarding brilliance and color strength, strong hiding power, good dispersibility, light fastness and temperature stability.
Dmanisi hominin fossils and the problem of the multiple species in the early Homo genus
Authors: Guimarães Santiago Wolnei Ferreira , Merino Carlos Lorenzo 
Published: April 2021

The D4500 (Skull 5), dated 1.8 Mya., is the most complete fossil within the set of five skulls found in Dmanisi, Georgia, as well as any other fossils associated to contexts of occupation of the early Pleistocene. Its discovery has brought forward the debate of the plurality of species, not just at the beginning of the Homo genus, but for much of its evolution. The Skull 5 fossil presents a mixure of primitive and derivates characters associated to the Homo erectus and Homo habilis sensu lato. Based on the data referring to the five skulls researchers have considered the hypothesis of a single evolving lineage of early Homo as a mode to explain the great variation range of the Dmanisi fossils, similar to the range found in habilines. In other words, it is an explanation that reiterates the existence of only one unique species in the early of the Homo genus: the Homo erectus in a sensu lato. Our work consists of evaluating such supposition through the calculation of the coefficient of variation, which was estimated from the referred set and compared to those from already known species. Results achieved did not support the thinking that one unique species was able to bear all fossils of the early of Homo genus.
Review of Glomerular Diseases: Focal Segmental Glomerulosclerosis (FSGS) and Minimal Change Disease (MCD)
Authors: Sohi Gursharan Kaur 
Published: April 2021

Purpose: Idiopathic focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) are chronic glomerulopathies which may compromise patients’ quality of life, and for which there is no cure. This literature review aimed to summarize our current understanding of the pathophysiology, clinical characteristics, and best available treatment for the two conditions in order to outline a consolidated treatment protocol and identify future research considerations.
Methods: PubMed was systematically searched by a single reviewer in order to identify primary studies pertaining to the diagnosis, treatment and classification of FSGS and MCD. Additionally, a hand search of UpToDate was conducted to glean further information about the best available evidence as summarized for clinician use. Relevant information was extracted and synthesized.
Results: Primary FSGS and MCD result from distinct pathogenic mechanisms, hypothesized to involve kidney injury via immune dysregulation. Patients require a kidney biopsy for diagnostic purposes. First-line treatment involves glucocorticoids (i.e. prednisone), although patients’ responsiveness may be inconsistent; second-line treatment is immunotherapy.
Conclusion: This review summarized clinically-important information about FSGS and MCD, and emphasized the need for further research in the field of clinical nephrology. Large scale trials such as the Cure Glomerulonephropathy should be conducted to gather information about the affected population.
Review on Anti-CD19 CAR T Therapy against B-Cell Malignancies and Future Implications
Authors: Tywonek Kasia M. , Hurtarte Milena 
Published: April 2021

This review examines CAR T CD19 immunotherapy, a newly FDA approved targeted therapy for B-Cell Acute Lymphoblastic Leukemia treatment. This therapy utilizes modified T cells from the patient's immune system, engineered to possess an anti-CD19 receptor that can recognize the specific CD19 antigen expressed on the surface of malignant B-lymphocytes. Using this highly individualized treatment, cancer types with a high rate of metastasis or relapse can be treated by the targeted nature of this therapy. The review aims to summarize the process through which CAR T was developed, from its inception to FDA approval. The material examined is current until March 2019 and explores the mechanisms and management of CAR T cell toxicity experienced by patients undergoing treatment. Clinical trials from respective stages of development are also detailed and summarized. The viable treatment options for patients suffering from B-cell acute lymphoblastic leukemia (B-ALL) are outlined. Despite the promising remission rates of CAR T therapy, its accessibility is limited due to current cost of treatment. With advancements in technology and improved understanding of immune-based therapies, it is possible that this method can become a more viable and affordable treatment option for patients in the future.
Urban health — What it is and Why We Should Care
Authors: Sood Tushar , Mammarella Bianca 
Published: April 2021

Urban health is a field of study that draws upon multiple disciplines including sociology, public health, epidemiology, and geography among others. This piece argues for the further development and prioritization of urban health as an area of research. This is discussed with respect to structural health inequalities, urbanization and urbanicity, and demographic change. Urban health is inherently complex and needs a multifaceted approach to tackle unique public health problems. This complexity, alongside its potential to inform emerging areas of scientific research such as neurourbanism, makes developing urban health of utmost priority.
A Hierarchy of Functional States in Working Memory
Authors: Muhle-Karbe Paul S. , Myers Nicholas E. , Stokes Mark G. 
Published: April 2021

Extensive research has examined how information is maintained in working memory (WM), but it remains unknown how WM is used to guide behavior. We addressed this question by combining human electrophysiology (50 subjects, male and female) with pattern analyses, cognitive modeling, and a task requiring the prolonged maintenance of two WM items and priority shifts between them. This enabled us to discern neural states coding for memories that were selected to guide the next decision from states coding for concurrently held memories that were maintained for later use, and to examine how these states contribute to WM-based decisions. Selected memories were encoded in a functionally active state. This state was reflected in spontaneous brain activity during the delay period, closely tracked moment-to-moment fluctuations in the quality of evidence integration, and also predicted when memories would interfere with each other. In contrast, concurrently held memories were encoded in a functionally latent state. This state was reflected only in stimulus-evoked brain activity, tracked memory precision at longer timescales, but did not engage with ongoing decision dynamics. Intriguingly, the two functional states were highly flexible, as priority could be dynamically shifted back and forth between memories without degrading their precision. These results delineate a hierarchy of functional states, whereby latent memories supporting general maintenance are transformed into active decision circuits to guide flexible behavior.SIGNIFICANCE STATEMENTWorking memory enables maintenance of information that is no longer available in the environment. Abundant neuroscientific work has examined where in the brain working memories are stored, but it remains unknown how they are represented and used to guide behavior. Our study shows that working memories are represented in qualitatively different formats, depending on behavioral priorities. Memories that are selected for guiding behavior are encoded in an active state that transforms sensory input into decision variables, whereas other concurrently held memories are encoded in a latent state that supports precise maintenance without affecting ongoing cognition. These results dissociate mechanisms supporting memory storage and usage, and open the door to reveal not only where memories are stored but also how.
Creative Emotion and Understanding of Democracy in the Philosophy of H. Bergson
Authors: Aleksandravičius Povilas 
Published: April 2021

In this paper, the concept of creative emotion (émotion créatrice) and the understanding of democracy, which arises out of it, in the philosophy of Bergson is analysed. This specific emotion does not depend on an object’s intellectual representation; therefore, Bergson refers to it as “supra-intellectual.” Contrary to the usual “infra-intellectual” emotions, it is primary in regard of the mind and the will, and it comprises the fundamental matrix of creative acts of the human being. Creative emotion is one of the forms of the intuition of duration that is rooted in élan vital. It not only determines the essential changes in the fields of art, religion or science, but also re-configures the political rationality by revealing a deeper form of sociality. Thus, the presumed anti-sociality of the philosophy of Bergson is denied. In his last work, The Two Sources of Morality and Religion, Bergson shows how creative emotion transforms understanding of democracy and how it turns this political conception into a dynamic movement corresponding to the deep process of the human being and the whole reality.
Anti-Metaphysical Readings of Tractatus Logico-Philosophicus
Authors: Tarai Ashoka Kumar 
Published: April 2021

This paper discusses certain anti-metaphysical readings of Tractatus Logico-Philosophicus. The metaphysical and anti-metaphysical readings can be divided on the interpretations of textual fidelity. The anti-metaphysical readings can be differentiated in taking into account two different understandings with regard to Wittgenstein’s pronouncement of nonsense in Tractatus. One is the logical positivists’ understanding of nonsense and the other is the resolute reading of the text that emerged as an opposite to the orthodox or standard reading. The aim of discussing these anti-metaphysical readings is to highlight whether a metaphysical reading is possible.
Ressentiment in Egalitarian Movements: Slavoj Žižek’s Response to Peter Sloterdijk
Authors: Andrijauskas Jokūbas 
Published: April 2021

I discuss Peter Sloterdijk’s critique of egalitarian projects presented in his book Zorn und Zeit and Slavoj Žižek’s response to it. My claim is that both of these thinkers show an oscillation between polemical and analytical aspects when using the concept of ressentiment. By using the concept of ressentiment, Sloterdijk explains the transformation of anger in Western societies. He holds that the atemporal anger, which characterized ancient greeks assumes a temporal form and becomes the project of revenge and ressentiment under Christianity and later emancipatory movements. I show that alongside this view, the author implies a political-polemical argumentation with the intent of delegitimizing the political left movements. Then I discuss the notion of ressentiment in Žižek’s view, which implies the same ambivalence, on the one hand, this concept is introduced as an alternative to Sloterdijk’s attempts at delegitimization, on the other, it seeks to explain anger and revenge related phenomena. At last, I claim that Sloterdijk’s and Žižek’s positions differ on the polemical aspect, but are compatible analytically.
The Community Velocity Model V.1.0 of Southwest China, Constructed from Joint Body- and Surface-Wave Travel-Time Tomography
Authors: Liu Ying , Yao Huajian , Zhang Haijiang , Fang Hongjian 
Published: April 2021

Abstract
Southwest China, located at the southeastern margin of the Tibetan plateau, plays an important role for the plateau growth and its material extrusion. It has complicated tectonic environment and strong seismic activities including the 2008 Wenchuan great earthquake. Numerous geophysical studies have been conducted in southwest China. However, a community velocity model (CVM) in this region is still not available, which makes it difficult to have a consistent catalog of earthquake locations and focal mechanisms and a consistent velocity model for simulating strong ground motions and evaluating earthquake hazards. In this study, we aim at building a high-resolution CVM (both VP and VS) of the crust and uppermost mantle in southwest China along with earthquake locations by joint inversion of body- and surface-wave travel-time data. In total, we have assembled 386,958 P- and 372,662 S-wave first arrival times and nearly 8100 Rayleigh-wave dispersion curves in the period band of 5–50 s. A multigrid strategy is adopted in the joint inversion. A coarser horizontal grid interval of 0.5° is first used and then a finer grid interval of 0.25° is used with initial models interpolated from the coarser-grid inverted velocity models. The spatial resolution of both VP and VS models can reach up to 0.5° horizontally and 10 km vertically according to the checkerboard tests. The comparisons of our inverted VP and VS models with those from other studies show general consistency in large-scale features. The inverted models are further validated by P-wave arrival times from active sources and Rayleigh-wave data. In general, our velocity models show two low-velocity zones in the middle-lower crust and a prominent high-velocity region in between them. Our new models have been served as the first version of the CVM in southwest China (SWChinaCVM-1.0) for future studies.
Structure and Dynamics of the Southern Rocky Mountain Trench near Valemount, British Columbia, Inferred from Local Seismicity
Authors: Purba Joshua C. S. , Gilbert Hersh , Dettmer Jan 
Published: April 2021

AbstractStretching nearly the extent of the Canadian Cordillera, the Rocky Mountain trench (RMT) forms one of the longest valleys on Earth. Yet, the level of seismicity, and style of faulting, on the RMT remains poorly known. We assess earthquakes in the southern RMT using a temporary network of seismometers around Valemount, British Columbia, and identify active structures using a probabilistic earthquake catalog spanning from September 2017 to August 2018. Together with results from earlier geological and seismic studies, our new earthquake catalog provides a constraint on the geometry of subsurface faults and their level of activity during a year of recording. The tectonic analysis presented here benefits from the catalog of 47 earthquakes, including robust horizontal and vertical uncertainty quantification. The westward dip of the southern RMT fault is one of the prominent subsurface structures that we observe. The seismicity observed here occurs on smaller surrounding faults away from the RMT and shifts from the east to the west of the trench from north to south of Valemount. The change in distribution of earthquakes follows changes in the style of deformation along the length of the RMT. Focal mechanisms calculated for two earthquakes with particularly clear waveforms reveal northeast–southwest-oriented thrusting. The seismicity reveals a change in the pattern of deformation from narrowly focused transpression north of Valemount to more broadly distributed activity in an area characterized by normal faulting to the south. Six sets of repeating events detected here produce similar waveforms whose P waves exhibit correlation coefficients that exceed 0.7 and may result from the migration of fluids through the fractured crust.
Swell-Triggered Seismicity at the Near-Front Damage Zone of the Ross Ice Shelf
Authors: Aster Richard C. , Lipovsky Bradley P. , Cole Hank M. , Bromirski Peter D. , Gerstoft Peter , Nyblade Andrew , Wiens Douglas A. , Stephen Ralph 
Published: April 2021

Abstract
Ocean swell interacting with Antarctic ice shelves produces sustained (approximately, 2×106 cycles per year) gravity-elastic perturbations with deformation amplitudes near the ice front as large as tens to hundreds of nanostrain. This process is the most energetically excited during the austral summer, when sea ice-induced swell attenuation is at a minimum. A 2014–2017 deployment of broadband seismographs on the Ross Ice shelf, which included three stations sited, approximately, 2 km from the ice front, reveals prolific swell-associated triggering of discrete near-ice-front (magnitude≲0) seismic subevents, for which we identify three generic types. During some strong swell episodes, subevent timing becomes sufficiently phase-locked with swell excitation, to create prominent harmonic features in spectra calculated across sufficiently lengthy time windows via a Dirac comb effect, for which we articulate a theoretical development for randomized interevent times. These events are observable at near-front stations, have dominant frequency content between 0.5 and 20 Hz, and, in many cases, show highly repetitive waveforms. Matched filtering detection and analysis shows that events occur at a low-background rate during all swell states, but become particularly strongly excited during large amplitude swell at rates of up to many thousands per day. The superimposed elastic energy from swell-triggered sources illuminates the shelf interior as extensional (elastic plate) Lamb waves that are observable more than 100 km from the ice edge. Seismic swarms show threshold excitation and hysteresis with respect to rising and falling swell excitation. This behavior is consistent with repeated seismogenic fracture excitation and growth within a near-ice-front damage zone, encompassing fracture features seen in satellite imagery. A much smaller population of distinctly larger near-front seismic events, previously noted to be weakly associated with extended periods of swell perturbation, likely indicate calving or other larger-scale ice failures near the shelf front.