bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the in vivo acute toxicity of poly(thioether‐ester) and superparamagnetic poly(thioether‐ester) nanoparticles obtained by thiol‐ene miniemulsion polymerization
Authors: Feuser Paulo Emilio , Cardoso Mariana de Melo , Galvani Nathalia Coral , Zaccaron Rubya Pereira , Venturini Ligia Milanez , Rigo Flavia Karine , Machado‐de‐Ávila Ricardo Andrez , Silveira Paulo Cesar Lock , Sayer Claudia , Hermes de Araújo Pedro Henrique 
Published: October 2021

AbstractPoly(thioether‐ester) (PTEe) nanoparticles obtained by thiol‐ene polymerization have received attention of many researchers due to several advantages, including, biocompatibility and biodegradability. The search for new nanomaterials requires toxicity studies to assess potential toxic effects of their administration. Therefore, the aim of this study was to evaluate the in vivo acute toxicity of PTEe and poly(thioether‐ester)‐coated magnetic nanoparticles prepared by thiol‐ene polymerization in miniemulsion. These nanoparticles presented a mean size of approximately 120 nm, spherical morphology, and negative surface charge. Doses of 40 mg/kg were administered intraperitoneally to Swiss mice and nociceptive, behavioral and biochemical parameters were investigated in five different organs. None of the nanoparticles led to any alterations in the nociceptive and behavioral responses. Biochemical alterations were observed in liver, decreasing the sulfhydryl and glutathione (GSH) levels, suggesting the dependence of the GSH metabolism in the elimination of the nanoparticles. In general, both nanoparticle types did not cause disturbances in biochemical parameters analyzed in others organs. These results suggest that both nanoparticle types did not induce acute toxicity to the different organs evaluated, reinforcing the biocompatibility of PTEe nanoparticles synthetized by thiol‐ene polymerization.
CircRNAs: a family number of miRNA regulatory transcriptome in laryngeal carcinoma
Authors: Miao Limin , Feng Guanying , Yuan Hua 
Published: October 2021

AbstractLaryngeal carcinoma (LC) is a common head and neck cancer, which is the result of mutational changes due to gene dysregulation and etiological factors such as tobacco and smoking. A large number of patients received a poor prognosis due to diagnosis at an advanced stage. This highlights the need for definitive, early, and efficient diagnoses. With rapid development of high‐throughput sequencing, circular RNA (circRNA) has been reported to play a pivotal role in cancer. CircRNA functions as a microRNA (miRNA) sponge in the regulation of mRNA expression, forming circRNA‐miRNA regulatory axis. In this review, we described the axis in LC. The result indicated that CDR1as, hsa_circ_0042823, hsa_circ_0023028, circPARD3, hsa_circ_103862, hsa_circ_0000218, circMYLK, circCORO1C, hsa_circ_100290, circ‐CCND1, hsa_circ_0057481, circFLAN, and circRASSF2 expressed higher in LC, whereas, hsa_circ_0036722 and hsa_circ_0042666 expressed lower. The circRNAs regulated the target genes by sponging miRNAs and contributed to the pathogenesis of LC.
Pretreatment and enzymatic hydrolysis of coffee husk for the production of potentially fermentable sugars
Authors: Silva Nayara CS , da Fonseca Yasmim A , de Camargos Adonai B , Lima André LD , Ribeiro Marcelo C , Gurgel Leandro VA , Lobo Baêta Bruno E 
Published: October 2021

AbstractBACKGROUNDCoffee husk (CH) is the main agricultural solid waste generated during the coffee bean dry processing. Therefore, it is necessary to investigate other alternatives for the more noble use of this by‐product, adding value to it considering the circular economy concept within the coffee production chain. This study aimed to add value to CH by liquid hot water (LHW) pretreatment as an alternative to improve the enzymatic conversion of polysaccharides of this substrate to fermentable sugars through enzymatic hydrolysis.RESULTSBox–Behnken experimental design was used to evaluate the effect of LHW pretreatment on the enzymatic hydrolysis yield (EHY), investigating the independent variables time (t), temperature (T), and liquid‐to‐solid ratio (LSR). The desirable condition (200 °C, 41 min, LSR of 5 mL g−1) was selected as the most suitable for the enzymatic hydrolysis, reaching an EHY value of 75.3% with an enzyme load of 40 FPU g PCH−1. The alkaline extraction step applied to pretreated coffee husk (PCH) was not effective to improve the EHY, as the cellulose fraction was not preserved. Two reloads of solids were considered an ideal condition, reaching an EHY value of 69.1% after 24 h of hydrolysis with a total enzyme load of 27 FPU g PCH−1.CONCLUSIONThe liquid hot water of CHs associated with the reload of solids on enzymatic hydrolysis is an interesting alternative to reduce the cost with enzyme cocktail and hydrolysis time, thus making the process more feasible for technology upscaling. © 2021 Society of Chemical Industry (SCI).
Synthesis of novel Schiff bases as stable enol‐imine‐containing diazene bonds and pyrimidines using trimethinium salts
Authors: Mehranpour Abdolmohammad , Sheikhi Elham , Jahromi Enayatollah Bahman , Samani Ziba Rafiee 
Published: October 2021

AbstractNovel derivatives of Schiff bases with diazene bonds and six new 2,5‐disubstituted pyrimidine derivatives were synthesized by reaction of 2‐substituted trimethinium salts with 4‐aminoazobenzene or benzamidine hydrochloride, respectively, by a simple method and using inexpensive reagents. The purity and molecular structure of the new compounds were determined by elemental analysis, mass spectrometry, infrared, ultraviolet/visible, as well as proton nuclear magnetic resonance (1H NMR) and carbon‐13 nuclear magnetic resonance (13C NMR) spectroscopy.
The Japanese Catheter Ablation Registry (J‐AB): Annual report in 2019
Authors: Kusano Kengo , Yamane Teiichi , Inoue Koichi , Takegami Misa , Nakao Yoko M. , Nakai Michikazu , Kanaoka Koshiro , Miyamoto Koji , Iwasaki Yu‐ki , Takatsuki Seiji , Nakamura Kohki , Miyamoto Yoshihiro , Shoda Morio , Nogami Akihiko , Shimizu Wataru ,   J‐AB registry investigators
Published: October 2021

AbstractThe Japanese Catheter Ablation (J‐AB) registry, started in August 2017, is a voluntary, nationwide, multicenter, prospective, observational registry, performed by the Japanese Heart Rhythm Society (JHRS) in collaboration with the National Cerebral and Cardiovascular Center using a Research Electronic Data Capture system. The purpose of this registry is to collect the details of target arrhythmias, the ablation procedures, including the type of target arrhythmias, outcomes, and acute complications in the real‐world settings. During the year of 2019, we have collected a total of 80 795 procedures (mean age of 65.2 years and 66.4% male) from 425 participant hospitals. Detailed data are shown in Figures and Tables.
Should firms use digital work instructions?—Individual learning in an agile manufacturing setting
Authors: Letmathe Peter , Rößler Marc 
Published: October 2021

AbstractNew technological innovations in robotics, automation, and digitization enable agile manufacturing, smaller lot sizes, and quicker changes to the product and the production process. In such environments, learning is important, since workers must learn new tasks and adapt to frequent changes quickly. In an experimental study, we compare digital work instructions with traditional paper‐based ones, the latter still being common in today's quality management systems. Our analysis is based on subjects working in the demonstration factory of a large German university in a realistic work environment; it, therefore, guarantees high internal and external validity. We show that digitally animated, interactive work instructions are an effective way to foster faster learning and enhanced performance when new manufacturing tasks are being carried out. Our results indicate that a combination of digital and traditional paper‐based instructions does not yield any advantages over a sole reliance on digital learning.
Infliximab switching from reference product to biosimilar: a review of evidence regarding the clinical efficacy, safety profile and immunogenicity
Authors: Abidin Ahmad Zainal , Snoswell Centaine L. , Shafiee Hanjani Leila , Callaghan Gavin , Edmonds Michelle 
Published: October 2021

AbstractBiosimilar products are now readily available for infliximab which is routinely used to treat rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) along with other conditions. This review aimed to summarise the available evidence on the clinical efficacy, safety profile, and immunogenicity of a biosimilar as compared to the reference product to address the concern of clinicians in switching from the reference product to a biosimilar. We searched PubMed, Embase, and Cochrane Library using the following terms: 'infliximab', 'biosimilar', 'reference product', AND 'switch'. Further relevant articles were identified through exploring the reference lists of the identified articles. Ten randomised clinical trials, enrolling 2308 patients, and 13 observational studies, enrolling 4453 patients, were identified. The results of these studies suggest that the efficacy of a biosimilar is comparable to that of the reference product in patients with RA, AS, and IBD. This study found that a biosimilar is well‐tolerated and has a similar profile of safety as the reference product. The observational cohort studies involving patients switched from the reference product to a biosimilar reported comparable efficacy at maintaining disease remission. They also indicated stable disease activity and no considerable changes in the inflammatory markers after the switch. The evidence, which is ever‐increasing, indicates that the use of a biosimilar is effective, well‐tolerated, safe, and comparable in terms of immunogenicity, even in the long run. The availability of a biosimilar would ultimately improve patient access to treatment, and in turn, reduce the price of the reference drug.
Electronic nose application for the discrimination of sterilization treatments applied to Californian‐style black olive varieties
Authors: Sánchez Ramiro , Martín‐Tornero Elísabet , Lozano Jesús , Fernández Antonio , Arroyo Patricia , Meléndez Félix , Martín‐Vertedor Daniel 
Published: October 2021

AbstractBACKGROUNDOlive oil continues to be the main destination for olives. The production of table olives is increasing. ‘Californian‐style’ processes are among the most frequently employed to produce oxidized olives. Sensory evaluation requires the development of an instrumental detection method that can be used as an adjunct to traditional tasting panels.RESULTSAn electronic nose (E‐nose) was used to classify two varieties of olives following exposure to different sterilization. Principal component analysis (PCA) revealed that both varieties had different volatile profiles. Sensory panel evaluations were similar for both. Partial least squares‐discriminant analysis (PLS‐DA) obtained from the E‐nose was able to separate the two varieties and explained 82% of total variance. Moreover, volatile profiles correctly classified olives according to sterilization times recorded up to 121 °C . The only exception was at F0 ≥ 22 min, at which a plot of PCA outcomes failed to differentiate scores. E‐nose data showed similar results to those produced from the volatile analysis when grouping samples were sterilized to F0 ≥ 18 min, at the same time distinguishing these samples from those subjected to less intense thermal treatments. A partial least squares (PLS) chemometric approach was evaluated for quantifying important olive quality parameters. With regards to validation parameters, pertaining to perceived defect was 0.88, whilst pertaining to overall assessment was 0.78.CONCLUSIONSE‐nose offers a fast, inexpensive and non‐destructive method for discriminating between varieties and thermal treatments up to a point at which cooking defects are highly similar (from F0 = 18 onwards). © 2021 Society of Chemical Industry.
Impact of zinc and plant growth‐promoting bacteria on soil health as well as aboveground biomass of desi and kabuli chickpea under arid conditions
Authors: Ullah Aman , Farooq Muhammad , Qadeer Abdul , Sanaullah Muhammad 
Published: October 2021

AbstractBACKGROUNDZinc (Zn) deficiency and low soil fertility are the major factors responsible for low yield in chickpea. This study was conducted to evaluate the effect of Zn application and plant growth‐promoting bacteria (PGPB) (endophyte Enterobacter sp. MN17) on soil health and aboveground biomass of desi and kabuli chickpea under natural field conditions. Zn was applied as seed priming (0.001 mol L−1) and soil application (10 kg Zn ha−1) with and without PGPB. To determine the impacts of Zn and PGPB on soil biological health, soil microbial biomass carbon (MBC) and soil extracellular enzyme activities were analyzed at two growth stages: vegetative (90 days after sowing) and maturity (163 days after sowing).RESULTSThe highest aboveground biomass (5.1 t ha−1) was recorded with Zn seed priming + PGPB in kabuli chickpea and in desi chickpea (4.8 t ha−1) with Zn seed priming only. The application of Zn significantly increased soil MBC, which was higher in kabuli (795 and 731 μg C g−1) compared to desi chickpea (655 and 533 μg C g−1) at both vegetative and reproductive growth stages, respectively. The highest extracellular soil enzyme activities, – β‐glucosidase (4758 nmol g−1 h−1), acid phosphatase (5508 nmol g−1 h−1), chitinase (5997 nmol g−1 h−1) and leucine aminopeptidase (993 nmol g−1 h−1) – were recorded with Zn seed priming. Of the chickpea types, kabuli chickpea had higher soil extracellular enzyme activities in the rhizosphere than desi chickpea.CONCLUSIONZn seed priming along with PGPB application may improve soil health and chickpea biomass in marginal soils. © 2021 Society of Chemical Industry.
Does sulfur application continue to reduce cadmium accumulation and increase the seed yield of oilseed rape (Brassica napusL.) at the maturity stage?
Authors: Huang Lijuan , Hansen Hans C B , Yang Xiaosong , Xie Zijian , Li Songyan , Yang Mei , Liang Xiaomeng , Hu Zhengyi 
Published: October 2021

AbstractBACKGROUNDOilseed rape requires sulfur (S) fertilization. Cadmium (Cd) differs dramatically in agricultural soils. Rice–oilseed rape rotation distributes widely and contributes the majority of rapeseeds in Asian countries. It was reported that S metabolism was involved in Cd uptake in seedlings of oilseed rape, although the effects of S on Cd accumulation and seed yield at maturity are still unclear.RESULTSWe performed a pot experiment including two Cd rates (0.35 and 10.35 mg kg−1, as low and high Cd soil) and four S levels (0, 30, 60 and 120 mg kg−1). The results showed that low S application (30 mg kg−1) resulted in two‐fold higher seed‐Cd concentration irrespective of soil Cd levels. The responsible mechanism might be that Cd translocation into rapeseeds was involved in sulfate transporters, which could be strongly expressed in shoots and roots when supplying sulfate under S‐starvation conditions, but depressed under a S‐sufficient environment. For high Cd soil, seed yield decreased by 36%, 48% and 72% at 30, 60 and 120 mg S kg–1 compared to non‐S treatment, whereas there were no differences for low Cd soil. Antagonistic effects of S and Cd existed for seed yield according to structure equation model analysis.CONCLUSIONOilseed rape can be grown in low‐Cd fields as a safe food crop with high levels of sulfur fertilizers (>60 mg S kg–1). In high‐Cd fields, oilseed rape is recommended as a Cd‐remediation crop, and rapeseeds should only be used for industrial purposes and not for food. © 2021 Society of Chemical Industry.
Sensory profile and acceptance of maize tortillas by rural and urban consumers in Mexico
Authors: Arnés Esperanza , Severiano‐Pérez Patricia , Astier Marta 
Published: October 2021

AbstractBACKGROUNDMaize tortillas are the staple food of Mexico and their consumption contributes to preserving the gastronomic patrimony and food security of the population. The aim of the present study was to generate a reference sensory profile for different types of tortillas and to evaluate the effect that these sensory characteristics have on consumer liking and how this influences their consumption preferences and purchase intent. Three types of maize tortillas were analyzed: traditional (T1), combined (T2) and industrialized (T3). The samples were characterized using the modified flash profile method. Sensory acceptability and preference tests were conducted on 240 urban and rural consumers.RESULTSThe judges characterized 19 attributes in the tortilla samples, eight of which were also identified by consumers. In the case of traditional tortillas, the matching attributes were maize flavor, color, thickness and moisture. Only rural consumers were able to perceive significant differences between the samples in terms of aroma and taste/flavor. The study has contributed to understanding the complex mechanisms of sensory acceptance through the use of tools that combine qualitative and quantitative data.CONCLUSIONAlthough 56% of rural and urban consumers prefer traditional tortillas for their sensory characteristics, purchase intent is also affected by socioeconomic, cultural and microbiological factors. © 2021 Society of Chemical Industry.
Candelilla wax‐based oleogels versus palm oil: evaluation of physical properties of innovative and conventional lipids using optical techniques
Authors: Szymańska Iwona , Żbikowska Anna , Onacik‐Gür Sylwia 
Published: October 2021

AbstractBACKGROUNDThe widespread use of palm oil in food production affects high consumption of long‐chain saturated fatty acids, which increases the risk of cardiovascular disease. Solid or semi‐solid wax‐based oleogels obtained as a result of edible oils structuring can be an alternative.RESULTSOleogels, obtained by structuring a mixture of refined rapeseed and linseed oils (1:1) with 30–80 g kg−1 candelilla wax (CW), were investigated using optical techniques: multi‐speckle diffusing wave spectroscopy, centrifugal stability analysis, reflection method, and polarized light microscopy. Refined palm oil was a comparative sample. Increasing CW concentration resulted in an increase in values of L* parameter and opacity, a decrease in the Yellowness Index and a slight increase in the average crystal size. The microstructure of oleogels with 30 or 40 g kg−1 CW was least like the crystal network. Solidification of oleogels took place in two stages. Increase in CW concentration shortened solidification time and increased solidification temperature (greater elasticity of oleogels). Palm oil solidified the longest (497.1 min) and at the lowest temperature (29.3 °C). It showed lower resistance to centrifugal force than oleogels at 20 and 30 °C. All oleogels were stable (no oil release occurred) at 20 °C.CONCLUSIONOptical methods allow for an objective and detailed analysis of physical properties of palm oil and oleogels, as well as identification and tracking changes at the microstructural level over time. It has great potential in the edible lipid quality control at various stages of processing or storage. © 2021 Society of Chemical Industry.
Flavonoids and intestinal microbes interact to alleviate depression
Authors: Zhao Ke , Yao Mei , Zhang Xin , Xu Feng , Shao Xingfeng , Wei Yingying , Wang Hongfei 
Published: October 2021

AbstractFlavonoids have a variety of biological activities that are beneficial to human health. However, owing to low bioavailability, most flavonoids exert beneficial effects in the intestine through metabolism by the flora into a variety of structurally different derivatives. Also, flavonoids can modulate the type and structure of intestinal microorganisms to improve human health. It has been reported that the development of depression is accompanied by changes in the type and number of intestinal microorganisms, and gut microbes can significantly improve depressive symptoms through the gut–brain axis. Therefore, the interaction between flavonoids and intestinal microbes to alleviate depression is discussed. © 2021 Society of Chemical Industry.
Current considerations for radiotherapy in HPV‐associated head and neck cancer
Authors: Chen Linda , Riaz Nadeem , Lee Nancy , McBride Sean 
Published: October 2021

AbstractHuman papillomavirus (HPV)‐mediated oncogenesis confers increased sensitivity to radiotherapy and HPV head and neck cancer is associated with improved patient outcomes. As such, management of HPV‐related head and neck cancer requires a multidisciplinary approach that balances maximizing locoregional control with minimizing treatment‐related toxicity. We highlight considerations in radiation dose and target delineation, as well as considerations for chemoradiation, postoperative radiotherapy, and single modality, definitive radiotherapy.
Use of micro, capillary, and nano liquid chromatography for forensic analysis
Authors: Langford Joel B. , Lurie Ira S. 
Published: October 2021

AbstractThe use of micro, capillary, and nano liquid chromatography systems for forensic analysis has excellent potential. In a field where sample size is often limited, several studies have presented the viability of capillary columns with microflow and nanoflow, and when using mass spectrometric analysis limits of detection can be improved. Reduction in flow rates result in significant reduction in operating costs. Recent advances in miniaturized liquid chromatography systems also aim at in‐laboratory and on‐site detection, which have already been applied to forensic drug cases. This critical review will discuss the advantages, disadvantages, and applicability of microflow and nano liquid chromatography. In this regard, included in this article is a discussion of some promising areas not yet applied to forensic research.
Role of miR‐490‐3p in blocking bladder cancer growth through targeting the RNA‐binding protein PCBP2
Authors: Zhang Cun‐Ming , Song Li‐De , Wang Jun‐Wei , Ye Hai‐Bo , Chen Song 
Published: October 2021

AbstractMiR‐490‐3p is regarded as a tumor suppressor in many cancers, but whether miR‐490‐3p is involved in the development of bladder cancer remains unknown. BALB/c nude mice (male, 15–20 g) were used to investigate the role of MiR‐490‐3p in bladder cancer. The relationship between miR‐490‐3p and PCBP2 involved in bladder cancer regulation were determined. Cell viability, proliferation, and cell cycle were estimated by cell counting kit‐8 (CCK‐8) assay, 5‐bromo‐2′‐deoxyuridine (BrdU) detection, and flow cytometry analysis, respectively. In animal experiments, lentivirus was transfected into bladder cancer cells to overexpress miR‐490‐3p, which were then injected into mice and the change of tumor volume was assessed. Principal findings: The expression of MiR‐490‐3p was decreased in bladder cancer cells. Overexpression of miR‐490‐3p inhibited bladder cancer cell viability and proliferation. Moreover, overexpression of miR‐490‐3p caused cell cycle arrest in bladder cancer cells. The inhibitory effect of miR‐490‐3p on bladder cancer cells growth could be counteracted by enhancing PCBP2 expression. In vivo, bladder cancer growth in mice was blocked by miR‐490‐3p upregulation. MiR‐490‐3p suppressed bladder cancer growth and bladder cancer cell proliferation by down‐regulating PCBP2 expression.