bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving annual precipitation prediction using extreme learning machine with wavelet packet decomposition
Authors: Wang Hua , Wang Wenchuan , Du Yu-jin , Xu Dong-mei , Zhang Yi-duo 
Published: March 2021

Abstract
Accurate precipitation prediction can help plan for different water resources management demands and provide an extension of lead-time for the tactical and strategic planning of courses of action as well as activity. In this paper, a novel merged precipitation prediction framework (ELM-WPD) is proposed on the Extreme learning machine (ELM) with wavelet packet decomposition (WPD). The model can be described as the following: (a) we use the WPD to decompose the original precipitation data into several sub-layers; (b) ELM model is employed to complete the forecasting calculation for the decomposed series; (c) the results are integrated to complete the final prediction. Four quantitative indexes (RMSE, MAE, R and NSEC) are employed for the comparison criteria. The results are compared with Back-propagation neural network (BPNN), autoregressive integrated moving average model (ARIMA), ELM, BPNN-WPD model, ARIMA-WPD, indicating that the ELM-WPD model has better performance than other models used in this paper. Hence, the proposed method can provide higher accuracy and reliability for annual precipitation forecasting and can be extended to similar situations for precipitation forecasting.
Adaption of Hunter’s Method and generation of synthetic series from disaggregation of flow time series, comparative analysis with existing models
Authors: Mera Christian Paúl , Benavides-Muñoz Holger 
Published: March 2021

Abstract
Water demand is a non-deterministic variable; current normative deliver different flow rates than might occur. Adaptations have been developed in different countries mainly for Hunter's method. The Hydro-Sanitary Standard 'Norma Hidrosanitaria Ecuatoriana' (NHE) 2011 in Ecuador proposes a demand calculation through a modification to the Norme Francaise NF P 40–202. This study proposes an adaptation to the Hunter’s Method using a binomial probability function, based on the disaggregation of time series of pressure and flow, during 62 consumption days, in different water meters, in academic facilities in Loja, Ecuador. Flow curves were developed based on consumption units, which gave very assertive values in relation to the maximum recorded flow rates. Also, in order to approach different estimation methods and since water consumption over time follows a Poisson distribution, synthetic series were generated using the Neyman Scott Rectangular Pulse Model (NSRPM), as this is the one that most adheres to the actual user behavior. Maximum flow rate was also determined with Water Demand Calculator (WDC) and NHE 2011 for comparison with NSRP and research results. Current research is an exploratory approach, has a methodological value for subsequent studies. Proposed Hunter's Method adaptation can provide an accurate flow estimation. Flows obtained with NHE 2011 method were closed to observed only in small facilities. NSRPM method showed an exactness high level, with only a 1.1% percentage difference compared to the measured one.
Identification of candidate biomarkers associated with the diagnosis and prognosis of endometrial cancer: a bioinformatics analysis
Authors: Wei Changqiang , Huang Le , Deng Lingjie , Lin Huisi , Pan Weicheng , Pang Lihong 
Published: March 2021

Abstract
Background

Endometrial cancer (EC) is a common malignancy tumor that seriously threatens the wellbeing and health of women. This study aimed to map the hub genes and potential pathways that may be involved in EC.
Methods

In our study, three gene expression profiles of GEO and EC data from the TCGA database were analyzed. We performed WGCNA, and Cox regression analyses to screen hub genes and further validated them by using HPA, KM plots, and other databases. We also studied the methylation level by UCSC Xena and mutation of hub genes using Cbioportal .
Results

We identified 363 differentially expressed genes (DEGs) (146 upregulated and 217 downregulated genes). Pathway analysis revealed that hub genes are mainly related to cell cycle, DNA damage response, EMT, hormone ER, RAS/MAPK, and PI3K/AKT. Finally, we identified five hub genes that are related to the progression and prognosis of EC and screened several relevant small-molecule drugs.
Conclusions

MTHFD2, KIF4A, TPX2, RPS6KA6, and SIX1 were identified as candidate biomarkers for further basic and clinical research on endometrial cancer.
Diagnosis and treatment of Primary Cardiac Lymphoma: A Case Report
Authors: Ai Zhongping , Jiang Liang , Peng Mingyang , Yin Xindao , Xu Hui 
Published: March 2021

Abstract
Background: Primary cardiac lymphoma (PCL) is an extremely rare cardiac tumor and progresses rapidly, which often has short median survival time and poor prognosis unless diagnosed and treated in time.Case presentation: A 61-year-old man was admitted to hospital with repeated chest tightness and pain for 3 days and the right atrial mass by ultrasonography in the other hospital for 1 day. The echocardiography revealed an irregular hyperechoic mass in the right atrium with the size of the mass is about 5.3cm*4.3cm. Partial resection of right atrial tumor under general anesthesia and cardiopulmonary bypass was performed. After operation, enhanced chest computed tomography (CT) showed a mild enhancement mass in the right atrium. The histopathological examination revealed diffuse large B cell lymphoma. After careful examination, PCL was diagnosed and chemotherapy of low dose R-CHOP for 6 courses were used. After the last course, enhanced CT examination showed that the tumor almost disappeared and the patient's symptoms improved significantly.Conclusion: PCL is a extraordinarily rare disease with poor prognosis, and it is necessary to improve the awareness of this disease.Prompt diagnosis and timely chemotherapy in combination with surgery could lead to excellent clinical outcomes of the patient with PCL.
Connecting scientific advances and patented technologies: The role of open access scientific publishing in clean-technology innovation
Authors: Probst Benedict , Kontoleon Andreas , Anadon Laura Diaz 
Published: March 2021

Abstract
Getting to a net-zero economy requires faster development and diffusion of novel clean energy technologies. Understanding how the characteristics of scientific publications, such as the degree of accessibility, impact the development of technological innovations is critical. Yet, empirically establishing the links between scientific research and technological application (often studied using patents) is a highly under-researched area due to its complexity. Combining data science methods, machine learning, and econometrics, we develop and apply a novel approach to assess the determinants of the probability with which scientific discoveries (codified in scientific articles) are used in four major types of clean energy patents (i.e., batteries, biofuel, solar power, and wind power). We use data from more than 100,000 scientific articles and over 600,000 patents from these four technology categories for the period 2005 to 2018. Based on this data we first evaluate whether the diffusion time between scientific publishing and patented technologies has changed. We then investigate the effects of the characteristics of scientific articles on the probability that an article will be used in a patent as measured by citations in the non-patent literature. We also evaluate the effects of the characteristics of scientific articles that have been used by patents on the actual influence of the patent itself on other patents. We find that that the average lag between the publication of the scientific article and the citation of the patent has sharply decreased from on average 5-6 years in 2005 to less than 2 years in 2013. We also find that the most important predictor of whether a scientific article is used in a patent is whether it can be assessed without a paywall. In addition, we find that scientific articles that are cited more often by other scientific articles also lead to more influential patents. Our results indicate that the current scientific publication market structure – characterised by an oligopoly of publishers primarily relying on subscriptions from universities – is associated with a small but adverse effect on clean-tech innovation. Our results have profound implications for the transition to a carbon net-zero economy and could also have wider implications in other sectors (such as pharmaceuticals and biotechnology).
A Critical Ethnographic Study ff Discriminatory Social Practice During Clinical Practice in Emergency Medical Care
Authors: Maake Tshepo , Millar BT , Christopher LD , Naidoo N 
Published: March 2021

Abstract
Introduction: Post-apartheid, South Africa adopted an inclusive education system that was intended to be free of unfair discrimination. This qualitative study examines the experiences and perceptions of racial discrimination between Emergency Medical Care (EMC) students, clinical mentors, and patients within an Emergency Medical Service (EMS) during clinical practice. Understanding the nature of such discrimination is critical for redress.Methods: Within the conceptual framework of Critical Race Theory, critical ethnographic methodology explored how discriminatory social practice manifests during clinical practice. Semi-structured interviews enabled thematic analysis. We purposively sampled 13 undergraduate EMC students and 5 Emergency Care (EC) providers. Results: EMC student participants reported experiences of racial and gender discrimination during work-integrated learning (WIL) as they were treated differently on the basis of race and gender. Language was used as an intentional barrier to isolate students from the patients during WIL because EC providers would intentionally speak in a language not understood by the student and fail to translate vital medical information about the case, this prevented some students from engaging in clinical decision-making.Conclusion: Unfair discrimination within the pre-hospital setting have an impact on the learning opportunities of EMC students. Such practice violates basic human rights and has the potential to negatively affect the clinical management of patients, thus it has the potential to violate patient’s rights. This study confirms the existence of discriminatory practices during WIL which is usually unreported. The lack a structured approach to redress the discrimination causes a lack of inclusivity and equal access to clinical education.
ChAdOx1 nCoV-19 (AZD1222) Vaccine in People Living With and Without HIV
Authors: Madhi Shabir , Koen Anthonet , Fairlie Lee , Cutland Clare , Baillie Vicky , Padayachee Sherman , Dheda Keertan , Barnabas Shaun , Bhorat Qasim Ebrahim , Briner Carmen , Aley Parvinder , Bhikha Sutika , Hermanus Tandile , Horne Elizea , Jose Aylin , Kgagudi Prudence , Lambe Teresa , Masenya Masebole , Masilela Mduduzi , Moultrie Andrew , Mukendi Christian Kabasele , Moyo-Gwete Thandeka , Nana Amit Jawaharlal , Nzimande Ayanda , Patel Faeezah , Rhead Sarah , Taoushanis Carol , Thombrayil Asha , Eck Samuel van , Voysey Merryn , Villafana Tonya , Vekemans Johan , Gilbert Sarah , Pollard Andrew , Moore Penny , Izu Alane , Kwatra Gaurav 
Published: March 2021

Abstract
Coronavirus disease 2019 (COVID-19) is a public health emergency of international concern1. People living with HIV (PLWH) are at increased risk for adverse COVID-19 outcomes compared with HIV-negative individuals2-5, and are a high-risk group for COVID-19 prevention4. The ChAdOx1 nCoV-19 (AZD1222) vaccine has demonstrated safety and efficacy against COVID-19 in clinical trials6-8. To date, there are no reports on the safety and immunogenicity of this, or any COVID-19 vaccine, in PLWH, and reports on the immunogenicity of COVID-19 vaccines in Africa are limited9. Here, we show comparable safety and immunogenicity of two doses of ChAdOx1 nCoV-19 between PLWH and HIV-negative individuals in South Africa. Furthermore, in PLWH previously exposed to SARS-CoV-2, antibody responses increased substantially from baseline following a priming dose, with modest increases after a booster dose. Full-length spike and receptor-binding domain IgG geometric mean concentrations after a single dose of ChAdOx1 nCoV-19 in PLWH previously exposed to SARS-CoV-2 were 6.49–6.84-fold higher than after two doses in those who were SARS-CoV-2 naïve at enrollment. Neutralizing antibody responses were consistent with the antibody-binding responses. This is the first report of a COVID-19 vaccine specific to PLWH, and specific to Africa, and demonstrates favorable safety and immunogenicity of ChAdOx1 nCoV-19 in PLWH.
WITHDRAWN: Comparative study between the efficacy of long-pulsed Neodymium- YAG laser and Fractional CO2 laser in the treatment of striae distensae
Authors: AF Hendawy , DG Aly , HA Shokeir , NA Samy 
Published: March 2021

Abstract
Background: Striae Distansae (SD) are a disfiguring dermal lesion, characterized by lines of dermal atrophy, occurring at sites of dermal damage caused by stretching. They affect adolescents and more than 70% of pregnant females due to stretching of the skin.Objectives: To assess and to compare the effect of 1, 064 nm Long Pulsed (LP) Nd: YAG laser and Fractional CO2 laser clinically and histologically in treating SD.Materials/Methods: Thirty female patients with bilateral symmetrical SD were treated with Fractional CO2 laser on one side and long-pulsed Nd: YAG laser on the other side. All patients treated with 3 laser sessions at 3 weeks interval. Global Aesthetic improvement scale (GAIS) and the score of patient satisfaction were used to evaluate improvement 3 months post treatment. Four mm punch biopsies were taken from each side before treatment and 3 months after the last session to measure epidermal and collagen thickness.Results: More significant clinical improvement was noted with the Nd:YAG laser than Fractional CO2 laser. Both GAIS and satisfaction score were significantly higher in the Nd:YAG laser treated side epidermal and collagen thickness were evidently increased in the lesions treatd by Nd: YAG laser than those treated by Fractional CO2 laser with no significant difference.Conclusions: Long pulsed Nd-YAG laser is clinically more effective than the Fractional CO2 laser in treating SD without serious adverse effects, although there was no significant difference between them histopathologically.
Exploring of hypoglycemic mechanism of a Chinese Medicine Xiao-Ke-An based on target dipeptidyl peptidase-4：a molecular docking and molecular dynamics study
Authors: WANG Yong-Lin , ZHUANG Yan , TONG Yan , KONG Yuan-Fang , HU Yu-Long , LI Jie-Ming , WANG Shao-Pei , DONG Chun-Hong , LI Xiao-Fei 
Published: March 2021

Abstract
Xiao-Ke-An, a traditional Chinese medicine formula against diabetes in China, is reported inhibitory activity on Dipeptidyl peptidase-4 (DPP-4). However, its molecular mechanism is still unclear due to the complexity of its components. In this study, a combination of molecular docking, molecular dynamics (MD) and molecular mechanics/Poisson Boltzmann surface area (MM-PBSA) method was conducted. The results show that multiple components of Xiao-Ke-An can take effect on DPP-4 together, which could be the part of the hypoglycemic mechanism of Xiao-Ke-An. Of the eight selected compounds, MOL003714 shows the highest activity for inhibiting DPP-4 with the binding free energy of -44.14 kcal·mol− 1 via binding to the S2 and S'1 subsites of DPP-4, which could be a potent inhibitor for DPP-4. This study provided theoretical basis for the discovery and modification of natural DPP-4 inhibitors and the deeply insight into Xiao-Ke-An.
Identification of factors affecting the survival lifetime of HIV+ terminal patients in Albert Luthuli municipality of South Africa
Authors: Bengura Pepukai , Ndlovu Prince , Managa Annah Mulalo 
Published: March 2021

Abstract
Background: South Africa has the biggest HIV epidemic in the world, with Mpumalanga province in which Albert Luthuli municipality is located having the second highest HIV prevalence rate after KwaZulu-Natal province. The objective of the study was to identify the factors that affect the survival lifetime of HIV+ terminal patients in rural district hospitals of Albert Luthuli municipality.Methods: This is a typical retrospective cohort longitudinal design study whereby cohort of HIV+ terminal patients was retrospectively followed from 2010 to 2017 until a patient died, transferred to another hospital, lost to follow-up or was still alive at the end of the observation period. The follow-up time for each patient started at the time the patient got initiated to the ART programme at the hospital’s wellness centre. Nonparametric survival analysis and semiparametric survival analysis methods were used to analyse the data.Results: Through Cox proportional hazards regression modelling, it was found that ART adherence (poor, fair, good), Age, Follow-up mass, Baseline sodium, Baseline viral load, Follow CD4 count by Treatment (Regimen 1) interaction and Follow-up lymphocyte by TB history (yes, no) interaction had significant effects on survival lifetime of HIV+ terminal patients (p-values < 0.1). Furthermore, through quantile regression modelling, it was found that short, medium and long survival times of HIV+ patients, respectively represented by the 0.1, 0.5 and 0.9 quantiles, were not necessarily significantly affected by the same factors.Discussion: The Cox PH modelling and the quantile regression analysis complemented each other in answering the research question. However, although the Cox PH modelling was the main approach in this study, the quantile regression analysis results are more informative than the Cox PH modelling results.Conclusion: The study identified and modelled the factors affecting the survival of HIV+ terminal patients in Albert Luthuli Municipality by using Logistic regression, Cox PH regression, and Quantile regression modelling. . Cox regression modelled the factors affecting the survival lifetime of HIV+ terminal patients as: ART adherence, Age, Follow-up mass, Baseline sodium, Baseline viral load and interactions of Follow-up lymphocyte by TB history and Follow-up CD4 by Treatment (Regimen 1).
An evidence based surgical algorithm for management of Odontogenic keratocyst
Authors: Oginni Fadekemi Olufunmilayo , Alasseri Nasser , Ogundana Oladunni Mojirayo , Famurewa Bamidele Adetokunbo , Pogrel Anthony , Almoraissi Essam 
Published: March 2021

Abstract
The effective management of odontogenic keratocyst (OKC) remains a subject of interest and confusion in the Oral and Maxillofacial surgery literature. Currently, there is a lack of consensus regarding the most appropriate treatment for patients with odontogenic keratocyst. Of the various treatment options available, no modality to date has been shown to demonstrate a zero-or near zero recurrence rates except wide resection with clear margins. With the prevailing dearth of evidence based surgical protocols for the management of patients with odontogenic keratocyst in the literature, this study aims to present a surgical algorithm, based on meta-analysis results, that hopefully will be beneficial in enhancing treatment of patients with this condition. Using parameters of; size, lesion type (primary or secondary), syndromic or solitary nature of the lesion, presence of cortical perforations, and locularity; we present a decision tree, to aid treatment planning and help attain the least chance of recurrence in the management of the odontogenic keratocyst.
Association of dietary inflammatory index (DII) with Hypertriglyceridemic Waist Circumference Phenotype among Overweight and Obese Women: A cross sectional study
Authors: Tavakoli Atefeh , Mirzababaei Atieh , Moosavi Hanieh , Mehranfar Sanaz , Keshavarz Seyed-Ali , Mirzaei Khadijeh 
Published: March 2021

Abstract
Aims: Recent studies have shown that increased dietary inflammatory index (DII) score or consumption of pro-inflammatory foods can lead to increased waist circumference (WC) as well as triglyceride (TG) concentrations in obese people. The purpose of this study is to examine the association between DII and hypertriglyceridemic waist circumference phenotype (HTGWCP) in overweight and obese women. Methods: This study was performed on 226 obese women aged from 18 to 48 years. We evaluated DII score by semi-quantitative food frequency questionnaire (FFQ) of 147 items. Biochemical parameters were measured and anthropometric assessments were performed. Results: There was a positive significant correlation between DII and HTGWCPs. In other words, with an increase in DII score, the odds of having abnormal phenotypes including; enlarged waist normal TG (EWNT) (OR=2.85, 95% CI=1.02 to 7.98, P for trend=0.04) , normal waist enlarged TG (NWET) (OR=5.85, 95% CI=1.1 to 31.11, P for trend=0.03), enlarged waist enlarged TG (EWET) (OR=3.13, 95% CI=0.95 to 10.27, P for trend=0.05) increase compared to normal waist normal TG (NWNT) phenotype.Conclusion: Increasing DII scores can increase abnormal phenotypes so may increase WC and TG levels in overweight and obese women.
Experiment Regarding Magnetic Fields with Gravity
Authors: LEE JONG-HOON 
Published: March 2021

Abstract
When gravity exists in magnetic fields, gravity interacts with these magnetic fields to generate electricity in the direction the Earth spins or in the opposite direction. The relationships between electricity, voltage, and time can be redefined by analyzing data for 0.1 seconds. The voltage can be recorded on the x-axis, and time can be recorded on the y-axis. The electric potential energy generated due to interactions between gravity and magnetic seas can explain the time-dependent or time-independent equations of the Schrödinger equation through the data analysis.
Coping with homeschooling and caring for children during the UK COVID-19 lockdown: voices of working mothers&nbsp;
Authors: Kallitsoglou Angeliki , Topalli Pamela-Zoe 
Published: March 2021

Abstract
We examined working mothers’ experiences and feelings about homeschooling and caring for children while working during the summer 2020 COVID-19 lockdown in the UK. Eligible mothers were invited to participating in an on-line survey of open-ended questions that was distributed via social media between mid - June to mid-August 2020. Participants (n = 47; Mage = 39.6, range = 28 to 54 years) were predominantly white married working mothers and most had a higher education degree. The experience of combining homeschooling/caring while working was perceived difficult by many mothers and it was associated with feelings of stress about managing competing demands concurrently, guilt for not meeting the child’s needs, and worry over child socioemotional well-being and academic learning. Support from partner, work, and school were instrumental in improving maternal experience and emotional state. Finally, coping strategies that reflect mindfulness practices for stress management, were associated with positive experiences and feelings.