bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality
Authors: Talvi Salli , Jokinen Johanna , Sipilä Kalle , Rappu Pekka , Zhang Fu-Ping , Poutanen Matti , Rantakari Pia , Heino Jyrki 
Published: July 2021

AbstractEmbigin (gp70), a transmembrane glycoprotein, has been shown to regulate hematopoietic stem cell and progenitor cell niche. Still, little is known about its expression and function in other organ systems during development or adulthood. By combining immunofluorescence, RNA sequencing, and in vivo mouse models, we show that embigin is highly expressed during development and in adult lung, kidney, epididymis, skin, and testis. Adult Emb-/- mice have a normal lifespan and fertility without apparent pathologies. In contrast, the Emb-/- embryos are significantly smaller than their WT littermates. Markedly increased mortality of the Emb-/- embryos is seen especially during the neonatal period. Embigin is present in the placenta, but placental morphology and gene expression patterns stay unaltered. At E17.5, Emb-/- mice show defective morphogenesis of the lung, low alkaline phosphatase activity in amniotic fluid, and remarkable activation of genes involved in cell proliferation in the lungs. Thus, lung underdevelopment explains the high neonatal mortality. Our work demonstrates the crucial role of embigin during development, and it paves the way to further characterization of embigin in specific organ systems in development and homeostasis.Summary statementEmbigin is a basigin-group transmembrane glycoprotein. In vivo mouse model shows that embigin is crucial for embryonic lung development and neonatal survival.
Insula to mPFC Reciprocal Connectivity Differentially Underlies Novel Taste Neophobic Response and Learning
Authors: Kayyal Haneen , Chandran Sailendrakumar Kolatt , Yiannakas Adonis , Gould Nathaniel , Khamaisy Mohammad , Rosenblum Kobi 
Published: July 2021

AbstractTo survive in an ever-changing environment, animals must detect and learn salient information. The anterior insular cortex (aIC) and medial prefrontal cortex (mPFC) are heavily implicated in salience and novelty processing, and specifically, the processing of taste sensory information. Here, we examined the role of aIC-mPFC reciprocal connectivity in novel taste neophobia and memory formation, in mice. Using pERK and neuronal intrinsic properties as markers for neuronal activation, and retrograde AAV (rAAV) constructs for connectivity, we demonstrate a correlation between aIC-mPFC activity and novel taste experience. Furthermore, by expressing inhibitory chemogenetic receptors in these projections, we show that aIC-to-mPFC activity is necessary for both taste neophobia and its attenuation. However, activity within mPFC-to-aIC projections is essential only for the neophobic reaction but not for the learning process. These results provide an insight into the cortical circuitry needed to detect, react to- and learn salient stimuli, a process critically involved in psychiatric disorders.
The workplace culture in addiction psychiatry in Finland as described by healthcare personnel
Authors: Lyyra Eeva , Roos Mervi , Suominen Tarja 
Published: July 2021

Purpose
The purpose of this study is to describe the workplace culture and factors associated with it from the viewpoint of the personnel providing care to patients with dual diagnosis.

Design/methodology/approach
Data were collected from six organizations using an electronic survey in 2019. The respondents (n = 75) worked in addiction psychiatry in specialized health care and provided care to patients. The data were statistically analyzed.

Findings
Workplace culture was evaluated as positive. Stress was experienced occasionally (Md = 2.58, Q1 = 1.96, Q3 = 3.03), job satisfaction levels were moderate (Md = 4.83, Q1 = 4.28, Q3 = 5.44) and the practice environment was evaluated as neutral (Md = 4.46, Q1 = 4.00, Q3 = 5.04). Gender, age in years, employment relationship, work time, staffing, number of patients and the participants’ experience in health care and experience in their current workplace had statistically significant associations with workplace culture.

Originality/value
In Finland, there have been attempts to reform service structures that also influence mental health and substance addiction services. Workplace culture is one approach to promote service development. Yet, there has been no research on workplace culture in the context of the care of patients with dual diagnosis. The results of this study bring knowledge about how health-care personnel perceives stress, job satisfaction and their practice environment in addiction psychiatry, which can be used to further develop services and workplace culture.
“I have a dream” the vividness effect in international business communication
Authors: Brunzel Johannes , von der Oelsnitz Dietrich 
Published: July 2021

PurposeThe so-called vividness effect, painting a verbal picture to an audience and a key element of charismatic rhetoric, provides opportunities to make corporate communication more persuasive. The article seeks to provide evidence regarding: (1) the presence of the effect in written, international business communication and (2) whether vivid communication by top-level executives affects perception of their communication effectiveness.Design/methodology/approachThe article employs a qualitative, exploratory setting (focus groups) to examine the attitude of participants towards vivid communication of top-executives. The article also employs a computer-aided-content-analysis (CATA) in two of the most important stock indices (Deutsche Aktienindex and Dow Jones) from 2011 to 2015 to locate the presence of the rhetorical style in annual reports. Lastly, the article studies via a quasi-experimental approach whether this type of communication is perceived differently on the dimensions of communication effectiveness by Segars and Kohut (2001) using unique 485 responses from recruited US-citizens.FindingsThe article reveals empirically that companies make use of this type of communication across stock indices. The results of the conformational, quasi-experimental study (Study 3) suggests that vividness is perceived differently by an audience. Therefore, positive attributional effects are not univocally related to communication effectiveness but to the dimensions responsibility and customer commitment. The participants also attribute other desirable characteristics towards the speaker, thereby providing evidence for a partial positive effect of vividness on communication effectiveness.Originality/valueThe article employs an established measure of communication effectiveness and combines it with a key communication style from academia and industry. In addition, the article combines several methods to examine the construct (mixed-models).
The taming of the scoundrel: how to tempt European Millennials to engage in international work-related mobility
Authors: Koris Riina , Kollinger Iris 
Published: July 2021

Purpose
This research identifies the factors which motivate (or not) European Millennial students to accept work-related mobility. Insight into preferred length of mobility is also provided.

Design/methodology/approach
Quantitative self-report survey among 617 Millennial students from Europe. Data analysis for the quantitative survey used exploratory factor analysis and confirmatory factor analysis.

Findings
Reasons which add to as well as take from mobility willingness remain on the “personal” rather than “professional” side. The European Millennials would rather not accept long-term mobility, primarily for reasons related to family, friends and life in home country.

Practical implications
Organizations should design short-term assignments and enable flexibility for assignees to pursue personal interests while on mobility. Remuneration packages remain among the hygiene factors and organizations may have to adopt an individualized approach while creating mobility offers for the European Millennials.

Originality/value
This study shows which factors should be highlighted while designing work-related mobility offers to the European Millennials. As an original research, it offers highly practical value to organizations, thereby adding to their opportunity for flexibility during societal shifts.
Understanding design change propagation in complex engineering systems using a digital twin and design structure matrix
Authors: Chen Long , Whyte Jennifer 
Published: July 2021

PurposeAs the engineering design process becomes increasingly complex, multidisciplinary teams need to work together, integrating diverse expertise across a range of disciplinary models. Where changes arise, these design teams often find it difficult to handle these design changes due to the complexity and interdependencies inherent in engineering systems. This paper aims to develop an innovative approach to clarifying system interdependencies and predicting the design change propagation at the asset level in complex engineering systems based on the digital-twin-driven design structure matrix (DSM).Design/methodology/approachThe paper first defines the digital-twin-driven DSM in terms of elements and interdependencies, where the authors have defined three types of interdependency, namely, geospatial, physical and logical, at the asset level. The digital twin model was then used to generate the large-scale DSMs of complex engineering systems. The cluster analysis was further conducted based on the improved Idicula–Gutierrez–Thebeau algorithm (IGTA-Plus) to decompose such DSMs into modules for the convenience and efficiency of predicting design change propagation. Finally, a design change propagation prediction method based on the digital-twin-driven DSM has been developed by integrating the change prediction method (CPM), a load-capacity model and fuzzy linguistics. A section of an infrastructure mega-project in London was selected as a case study to illustrate and validate the developed approach.FindingsThe digital-twin-driven DSM has been formally defined by the spatial algebra and Industry Foundation Classes (IFC) schema. Based on the definitions, an innovative approach has been further developed to (1) automatically generate a digital-twin-driven DSM through the use of IFC files, (2) to decompose these large-scale DSMs into modules through the use of IGTA-Plus and (3) predict the design change propagation by integrating a digital-twin-driven DSM, CPM, a load-capacity model and fuzzy linguistics. From the case study, the results showed that the developed approach can help designers to predict and manage design changes quantitatively and conveniently.Originality/valueThis research contributes to a new perspective of the DSM and digital twin for design change management and can be beneficial to assist designers in making reasonable decisions when changing the designs of complex engineering systems.
The behavior of managers handling digital business transformations: theoretical issues and preliminary evidence from firms in the manufacturing industry
Authors: Matricano Diego , Castaldi Laura , Sorrentino Mario , Candelo Elena 
Published: July 2021

PurposeOrganizational culture plays a central role when dealing with the issue of digital business transformation (DBT). Managers handling a DBT and involved in digital strateging are expected to modify the organizational culture of firms to make it more fitting with the paradigm of digital economy and having more chance of success. Thus, it is noteworthy to inspect the role they can have over DBTs. Accordingly, the purpose of this paper is to investigate the behavior that managers assume when they approach DBTs by investigating whether they act as mentors/facilitators or entrepreneurs/innovators, as coordinators or decision makers.Design/methodology/approachTo achieve the above purpose, ten case studies about manufacturing firms have been selected. Case studies, retrieved by the Digital Innovation Observatories of the School of Management of the Politecnico di Milano, are studied and analyzed by means of a qualitative content analysis on textual data. This allows getting specific insights into organizational culture before and after DBT and about the role played by managers.FindingsAchieved results disclose that managers need to modify the organizational culture of their firms to handle a successful DBT. However, firms can assume different organizational culture and thus the role assumed by managers handling a DBT can change as well.Originality/valueTo the authors knowledge, this paper is among the first that aim to investigate the role that mangers assume when handling DBTs. In particular, originality lies in the fact that assumed roles are rebuilt in reference to their ability to modify organizational culture.
New media marketing as a driver of enterprise country of origin (COO) offer in international markets
Authors: Vrontis Demetris , Basile Gianpaolo 
Published: July 2021

PurposeThe paper aims to highlight the role of Web 2.0 in international marketing, shedding light on the relationships existing between the country of origin effect and consumer behavior.Design/methodology/approachThe current study, drawn on the country of the origin (COO)W literature and Web 2.0 diffusion data, investigates the relationships between country of origin – seen as an idiosyncratic entrepreneurial offer – and the consumer, within an international marketing framework. Specifically, the paper focuses on the increasing role of Web 2.0 and social media as tools enabling enterprises to create and maintain adaptive and networking capabilities and to implement international marketing strategies.FindingsThe findings presented here reveal that international marketing is becoming increasingly similar to domestic marketing because of social media development. In other words, it is becoming more and more difficult for international products to contain themselves within single markets as local issues seldom remain local.Originality/valueThis paper fills a gap in the international marketing literature focusing on how social media, particularly in a pandemic era, can improve and enhance relationships between the product of origin and consumer behavior both in the assessment and in the actual purchase of products.
Acceptance of MOOCs as an alternative for internship for management students during COVID-19 pandemic: an Indian perspective
Authors: Singh Archana , Sharma Anuj 
Published: July 2021

PurposeThe objective of this paper is to understand the benefits and utility of massive open online courses (MOOCs) as perceived by the student, vis-à-vis internship and determine the factors that influence student motivation and distraction in adoption of MOOCs.Design/methodology/approachAn empirical study is conducted through a survey; data are collected through a structured questionnaire. The technology acceptance model (TAM) is used as the base framework. For data analysis, Statistical Product and Service Solutions–Analysis of Moment Structures (SPSS–AMOS) 24.0 is used.FindingsThe impact of context-specific distinctive features of MOOCs and characteristics of students on user satisfaction are examined through perceived ease of use and perceived usefulness. In the study, it is found that positive social influence and better facilitating conditions improve perceived ease of use and perceived usefulness leading to a better user satisfaction. Self-regulation positively influences self-efficacy among students while pursuing MOOCs. Contrary to the past researches, it is found that in the pandemic environment self-efficacy is not impacting perceived ease of use, perceived usefulness and satisfaction.Practical implicationsThe findings of this study will benefit MOOCs developers and Higher Education Institutes (HEIs) in deeper understanding the significant factors affecting MOOC usage in higher education.Originality/valueThe study is ingrained to find the causes which will lead to user satisfaction of MOOCs by post-graduation students of B-schools in India. This is an original research and primary data has been collected for decision-making.
Systems and mechanisms to develop health volunteers for the health of immigrant workforce in Ubon Ratchathani, Thailand
Authors: Suvarnathong Preecha , Chai-Aroon Teeradej , Jiawiwatkul Uthaithip , Intoo-Marn Pasakorn 
Published: July 2021

PurposeThis study aims to examine the systems and mechanisms at provincial level to develop health volunteers to improve health of the immigrant workforce in Ubon Ratchathani, Thailand.Design/methodology/approachThis qualitative study collected data from document research and in-depth interviews with 22 concerned people who worked at policy and provincial levels to develop health volunteers to improve the health of immigrant workforce. Data were collected from May to July 2017. Then, content of the conceptual framework was analysed. The research objectives were examined and summary and induction analysis interpreted data from documents, observations and interviews.FindingsUbon Ratchathani has developed a Thai village health volunteer network to provide health care to immigrant workforce. This consisted of four systems and one supporting mechanism, namely, selection of health volunteer, knowledge management on primary health care, welfare management and moral enhancement and resource and budget support. Development is driven through the committee under the mechanisms of government agencies, i.e. the provincial public health office together with non-government organizations and network partners.Originality/valueThe findings from this study could help develop health volunteers to significantly improve the health of the immigrant workforce in the Thai health service system.
Memetic mapping and genealogy of Google’s organizational culture
Authors: Fesharaki Farzad 
Published: July 2021

Purpose
The purpose of this study is to describe the culture of Google using memetic mapping.

Design/methodology/approach
Printed and online texts published about Google are coded, and 40 memes are discovered. Memes are placed into six levels of organizational culture, namely, basic assumptions, values, norms, artifacts, work procedures and human resources practices.

Findings
To understand the formation of Google’s culture in the course of history, genealogy method is applied. In this approach, parent of each meme (the culture from which the meme is adopted) is identified. In total, 85 cultures that had impacts on the emergence of Google’s culture are recognized and analyzed.

Practical implications
Practical implications are presented as memetic engineering technique, which is capable of diagnosing and treating defective memes to facilitate and enhance the internal dynamics of corporate members.

Social implications
The application of this approach for tackling the challenges posed by the COVID-19 pandemic is discussed through a real-world example.

Originality/value
Memetic mapping is a powerful tool for managers, consultants and organizational researchers to explore the cultural phenomenon and change it to achieve higher performance.
Building social media-based knowledge ecosystems for enhancing business resilience through mass collaboration
Authors: Yu Ji , Pauleen David J. , Taskin Nazim , Jafarzadeh Hamed 
Published: July 2021

PurposeThe outbreak of COVID-19 is one of the most serious health events in recent times. In the business landscape, its effects may be more detrimental to micro-, small- and medium-sized enterprises (MSMEs) because they tend to have limited financial and human resources to manage the challenges caused by COVID-19. To help MSMEs enhance their resilience, this paper aims to discuss how they can leverage mass collaboration to build social media-based knowledge ecosystems to manage interactions among internal and external stakeholders for knowledge creation and innovation.Design/methodology/approachThe paper proposes a model for MSMEs to build an online knowledge ecosystem and a standalone text analytics tool to use the advanced data analytics, e.g. topic modeling, to analyze and aggregate collective insights. Design science research methodology is used to develop the model and the tool.FindingsThrough mass collaboration using social media and advanced data analytics technology, MSMEs can generate new business ideas, leading to enhanced resilience to meet the challenges caused by COVID-19 or other unexpected or extraordinary circumstances, such as natural disasters and financial crises.Originality/valueTo the best of authors’ knowledge, this paper is one of the first papers in social media adoption for knowledge creation and innovation research, providing detailed approaches for MSMEs to build a knowledge ecosystem on social media and to use advanced data analytics to mine the meaning of the generated data.
The interaction between supply networks and internal networks: performance implications
Authors: Chedid Fabienne , Kocabasoglu-Hillmer Canan , Ries Jörg M. 
Published: July 2021

PurposeThe importance of the supply network to firm performance is well documented. Until now, the firm and its suppliers have been conceptualized as single entities. Yet, multinational corporations (MNCs) are composed of a complex, geographically dispersed internal network of subsidiaries. The supply and internal networks are inherently linked. The purpose of this study is to investigate the impact of the interaction of these networks on firm-level financial performance.Design/methodology/approachBuilding on supply network, internal network and dual embeddedness research, the authors investigate the interaction of these networks using supply network data from FactSet and internal network data from Orbis. We assess the impact at the MNC level, using measures of firm-level financial performance, physical proximity between the two networks and geographic dispersion of the internal network.FindingsThe results show that the performance effect of physical proximity of the firm with its supply network is negatively moderated by the geographic dispersion of the firm's internal network. This effect can be traced back to the diminishing marginal profitability of a firm's assets. Moreover, the benefits of dual embeddedness to the individual subsidiary come at a cost at the firm-level due to the operational challenges of managing a complex subsidiary network.Research limitations/implicationsThis study is the first to investigate the supply and internal networks of MNCs simultaneously.Originality/valueThe paper extends supply network literature by considering the internal network of the focal firm and its suppliers. This paper is one of the first studies that offer an understanding of the interaction between supply and internal networks of a focal firm and the effect on financial performance.