bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social inequalities in availability of health-promoting interventions in Québec elementary schools
Authors: Riglea Teodora , Kalubi Jodi , Sylvestre Marie-Pierre , Maximova Katerina , Dutczak Hartley , Gariépy Geneviève , O’Loughlin Jennifer 
Published: February 2021

Summary
Availability of health-promoting interventions (HPIs) may vary across schools serving students with different socioeconomic backgrounds. Our objectives were to describe social inequalities across elementary schools in: (i) level of importance that school principals attribute to 13 common health-related issues among students in their school; (ii) availability of HPIs within their school addressing eight health topics and (iii) (mis)alignment between perceived importance and HPI availability. Data were collected in telephone interviews with school principals in a convenience sample of 171 elementary schools (59% of 291 schools contacted). Schools were categorized as serving very advantaged, moderately advantaged or disadvantaged students. Principals reported how important 13 health issues were among students in their schools and provided data on HPI availability for 8 health issues, 4 of which required school action under government mandates. Higher proportions of principals in schools serving disadvantaged students (36% of all 171 schools) perceived most health issues as important. The mean number of HPIs in the past year was 12.0, 12.1 and 11.7 in schools serving very advantaged, moderately advantaged and disadvantaged students, respectively. Only availability of mental health HPIs differed by school deprivation (60, 43 and 30% in very, moderately and disadvantaged, respectively). Although most schools offered oral health HPIs, dental problems were not perceived as important. Smoking was perceived as not important and smoking-related HPIs were relatively rare (9%). Given rapid evolution in public health priorities, (mis)alignment between perceived importance of specific health issues and HPI availability in elementary schools warrants ongoing reflection.
Ultra mare in servicio domini regis: English barons and the defence of Normandy, 1194–1204
Authors: Hopkinson Nick 
Published: February 2021

Abstract
This article analyses the provision of military service by English barons in the wars in Normandy between 1194 and 1204, a topic that has not previously been examined in any depth. It demonstrates that an important section of the English baronage provided regular military service in Normandy, driven by their own personal interests in the duchy and the pursuit of royal favour and rewards. It concludes that these barons were not fundamentally opposed to providing service overseas, and that this was not a factor in the loss of Normandy, but became an important political lever in their conflict with King John.
Evolutionary forces in diabetes and hypertension pathogenesis in Africans
Authors: Meeks Karlijn A C , Bentley Amy R , Adeyemo Adebowale A , Rotimi Charles N 
Published: February 2021

Abstract
Rates of type 2 diabetes (T2D) and hypertension are increasing rapidly in urbanizing sub-Saharan Africa (SSA). While lifestyle factors drive the increases in T2D and hypertension prevalence, evidence across populations shows that genetic variation, which is driven by evolutionary forces including a natural selection that shaped the human genome, also plays a role. Here we report the evidence for the effect of selection in African genomes on mechanisms underlying T2D and hypertension, including energy metabolism, adipose tissue biology, insulin action and salt retention. Selection effects found for variants in genes PPARA and TCF7L2 may have enabled Africans to respond to nutritional challenges by altering carbohydrate and lipid metabolism. Likewise, African-ancestry-specific characteristics of adipose tissue biology (low visceral adipose tissue [VAT], high intermuscular adipose tissue and a strong association between VAT and adiponectin) may have been selected for in response to nutritional and infectious disease challenges in the African environment. Evidence for selection effects on insulin action, including insulin resistance and secretion, has been found for several genes including MPHOSPH9, TMEM127, ZRANB3 and MC3R. These effects may have been historically adaptive in critical conditions, such as famine and inflammation. A strong correlation between hypertension susceptibility variants and latitude supports the hypothesis of selection for salt retention mechanisms in warm, humid climates. Nevertheless, adaptive genomics studies in African populations are scarce. More work is needed, particularly genomics studies covering the wide diversity of African populations in SSA and Africans in diaspora, as well as further functional assessment of established risk loci.
Locally Complete Intersection Maps and the Proxy Small Property
Authors: Briggs Benjamin , Iyengar Srikanth B , Letz Janina C , Pollitz Josh 
Published: February 2021

Abstract
It is proved that a map ${\varphi }\colon R\to S$ of commutative Noetherian rings that is essentially of finite type and flat is locally complete intersection if and only if $S$ is proxy small as a bimodule. This means that the thick subcategory generated by $S$ as a module over the enveloping algebra $S\otimes _RS$ contains a perfect complex supported fully on the diagonal ideal. This is in the spirit of the classical result that ${\varphi }$ is smooth if and only if $S$ is small as a bimodule; that is to say, it is itself equivalent to a perfect complex. The geometric analogue, dealing with maps between schemes, is also established. Applications include simpler proofs of factorization theorems for locally complete intersection maps.
Feeling better on hemodialysis: user-centered design requirements for promoting patient involvement in the prevention of treatment complications
Authors: Willis Matthew A , Hein Leah Brand , Hu Zhaoxian , Saran Rajiv , Argentina Marissa , Bragg-Gresham Jennifer , Krein Sarah L , Gillespie Brenda , Zheng Kai , Veinot Tiffany C 
Published: February 2021

Abstract

Objective
Hemodialysis patients frequently experience dialysis therapy sessions complicated by intradialytic hypotension (IDH), a major patient safety concern. We investigate user-centered design requirements for a theory-informed, peer mentoring-based, informatics intervention to activate patients toward IDH prevention.

Methods
We conducted observations (156 hours) and interviews (n = 28) with patients in 3 hemodialysis clinics, followed by 9 focus groups (including participatory design activities) with patients (n = 17). Inductive and deductive analyses resulted in themes and design principles linked to constructs from social, cognitive, and self-determination theories.

Results
Hemodialysis patients want an informatics intervention for IDH prevention that collapses distance between patients, peers, and family; harnesses patients’ strength of character and resolve in all parts of their life; respects and supports patients’ individual needs, preferences, and choices; and links “feeling better on dialysis” to becoming more involved in IDH prevention. Related design principles included designing for: depth of interpersonal connections; positivity; individual choice and initiative; and comprehension of connections and possible actions.

Discussion
Findings advance the design of informatics interventions by presenting design requirements for outpatient safety and addressing key design opportunities for informatics to support patient involvement; these include incorporation of behavior change theories. Results also demonstrate the meaning of design choices for hemodialysis patients in the context of their experiences; this may have applicability to other populations with serious illnesses.

Conclusion
The resulting patient-facing informatics intervention will be evaluated in a pragmatic cluster-randomized controlled trial in 28 hemodialysis facilities in 4 US regions.
Conflicting information from the Food and Drug Administration: Missed opportunity to lead standards for safe and effective medical artificial intelligence solutions
Authors: Hernandez-Boussard Tina , Lundgren Matthew P , Shah Nigam 
Published: February 2021

Abstract
The Food & Drug Administration (FDA) is considering the permanent exemption of premarket notification requirements for several Class I and II medical device products, including several artificial Intelligence (AI)–driven devices. The exemption is based on the need to rapidly more quickly disseminate devices to the public, estimated cost-savings, a lack of documented adverse events reported to the FDA’s database. However, this ignores emerging issues related to AI-based devices, including utility, reproducibility and bias that may not only affect an individual but entire populations. We urge the FDA to reinforce the messaging on safety and effectiveness regulations of AI-based Software as a Medical Device products to better promote fair AI-driven clinical decision tools and for preventing harm to the patients we serve.
The Effect of the Hypertrophy Virus (MdSGHV) on the Ultrastructure of the Salivary Glands ofMusca domestica(Diptera: Muscidae)
Authors: Molina Palacios D , Stoffolano J G , Fausto A M , Gambellini G , Burand J 
Published: February 2021

AbstractThe salivary glands of insects play a key role in the replication cycle and vectoring of viral pathogens. Consequently, Musca domestica (L.) (Diptera: Muscidae) and the Salivary Gland Hypertrophy Virus (MdSGHV) serve as a model to study insect vectoring of viruses. A better understanding of the structural changes of the salivary glands by the virus will help obtain a better picture of the pathological impact the virus has on adult flies. The salivary glands are a primary route for viruses to enter a new host. As such, studying the viral effect on the salivary glands is particularly important and can provide insights for the development of strategies to control the transmission of vector-borne diseases, such as dengue, malaria, Zika, and chikungunya virus. Using scanning and transmission electron microscopic techniques, researchers have shown the effects of infection by MdSGHV on the salivary glands; however, the exact location where the infection was found is unclear. For this reason, this study did a close examination of the effects of the hypertrophy virus on the salivary glands to locate the specific sites of infection. Here, we report that hypertrophy is present mainly in the secretory region, while other regions appeared unaffected. Moreover, there is a disruption of the cuticular, chitinous lining that separates the secretory cells from the lumen of the internal duct, and the disturbance of this lining makes it possible for the virus to enter the lumen. Thus, we report that the chitinous lining acts as an exit barrier of the salivary gland.
A Novel Radiologic Finding to Predict Ophthalmic Abnormalities in Children With Congenital Zika Syndrome
Authors: Sampaio Virginia Vilar , Melo Adriana S O , Coleman Anne L , Yu Fei , Martins Sarah Rogeria , Rabello Luciana Portela , Tavares Jousilene Sales , Nielsen-Saines Karin 
Published: February 2021

Abstract

Background
The Zika virus (ZIKV) epidemic had devastating consequences in Brazil. We investigated whether a radiologic finding (ie, infratentorial abnormalities) was associated with sight-threatening defects in children born with congenital Zika syndrome (CZS). We also investigated whether ophthalmic abnormalities correlated with head circumference (HC) and gestational age of infection.

Methods
Cross-sectional evaluation based upon a previous cohort from March 2016 to December 2018, in Paraíba, Brazil. The study population was comprised of children born to mothers with laboratory-confirmed ZIKV infection during pregnancy (ZIKV reverse transcriptase polymerase chain reaction [RT-PCR]+) and children born with clinical and radiologic features of CZS.

Results
A total of 75 infants had complete data. All 75 had brain calcifications. Microcephaly was present in 53 (71%) of them. Infratentorial abnormalities were present in 17 infants (22.7%). Ophthalmic abnormalities were seen in 16 of the 17 children (94%) with infratentorial abnormalities, while 28% of children without infratentorial abnormalities had ophthalmic findings (odds ratio [OR]: 42.0; 95% confidence interval [CI]: 5.1-342.9). Similar associations were observed when macular chorioretinal atrophy and optic nerve abnormalities were analyzed individually (OR: 23.7; 95% CI: 6.0-93.3 and OR: 11.5; 95% CI: 3.3-40.0, respectively). Infratentorial abnormalities were more frequently associated with ophthalmic abnormalities (94%) than microcephaly (43.4%) (P &lt; .001). Mean HC was statistically different between groups with and without ophthalmic abnormalities (P = .01). A statistically significant difference in gestational age between both groups was not noted (P = .12).

Conclusions
In children with CZS, the presence of infratentorial abnormalities is a significant predictor of ophthalmic abnormalities. All neonates whose mothers had ZIKV exposure during pregnancy should have an ophthalmologic examination.
Role of gut microbiota in travel-related acquisition of extended spectrum β-lactamase-producing Enterobacteriaceae
Authors: Peng Ye , Liang Suisha , Poonsuk Kanchana , On Hilda , Li Sze Wang , Maurin Morgan Maxime Pascal , Chan Ching Him , Chan Chak Lun , Sin Zhen Ye , Tun Hein Min 
Published: February 2021

Abstract

Background
International travel could facilitate the spread of antimicrobial-resistant bacteria including extended spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E). Previous studies, which attempted to understand the role of gut microbiota in the acquisition of antimicrobial resistant bacteria during international travels, are limited to western travellers.

Methods
We established a prospective cohort of 90 Hong Kong travellers to investigate gut microbiota determinants and associated risk factors for the acquisition of ESBL-E. Baseline characteristics and travel-associated risk factors were gathered through questionnaires. Faecal samples were collected in 3-4 days before and after travel. Antimicrobial susceptibility of ESBL-E isolates was tested, and gut microbiota were profiled by 16S rDNA amplicon sequencing. Non-parametric tests were used to detect potential associations, and logistic regression models were used to quantify the associations. Random forest models were constructed to identify microbial predictors for ESBL-E acquisition.

Results
In total, 49 (54.4%) participants were tested negative for ESBL-E colonization before travel and were followed up after travel. A total of 60 ESBL-E isolates were cultured from 20 (40.8%) participants. Having low Actinobacteria richness and low abundance of short-chain fatty acid-producing bacteria in the gut microbiota before travel increased the risk of acquiring ESBL-E and the risk can be further exacerbated by eating raw seafood during travel. Besides, post-travel ESBL-E positive participants had increased abundances of several opportunistic pathogens such as Staphylococcus, Enterococcus, Escherichia/Shigella and Klebsiella. The random forest model integrating pre-travel microbiota and the identified travel-related risk factor could predict ESBL-E acquisition with an area under the curve of 75.4% (95% confidence interval: 57.9–93.0%).

Conclusions
In this study, we identified both travel-related risk factors and microbiota predictors for the risk of ESBL-E acquisition. Our results provide foundational knowledge for future developments of microbiota-based interventions to prevent ESBL-E acquisition during international travels.
Clustering of local extrema in Planck CMB maps
Authors: Vafaei Sadr A , Movahed S M S 
Published: February 2021

ABSTRACT
The clustering of local extrema will be exploited to examine Gaussianity, asymmetry, and the footprint of the cosmic-string network on the CMB observed by Planck. The number density of local extrema (npk for peak and ntr for trough) and sharp clipping (npix) statistics support the Gaussianity hypothesis for all component separations. However, the pixel at the threshold reveals a more consistent treatment with respect to end-to-end simulations. A very tiny deviation from associated simulations in the context of trough density, in the threshold range ϑ ∈ [−2–0] for NILC and CR component separations, are detected. The unweighted two-point correlation function, Ψ, of the local extrema illustrates good consistency between different component separations and corresponding Gaussian simulations for almost all available thresholds. However, for high thresholds, a small deficit in the clustering of peaks is observed with respect to the Planck fiducial ΛCDM model. To put a significant constraint on the amplitude of the mass function based on the value of Ψ around the Doppler peak (θ ≈ 70–75 arcmin), we should consider ϑ ≲ 0.0. The scale-independent bias factors for the peak above a threshold for large separation angle and high threshold level are in agreement with the value expected for a pure Gaussian CMB. Applying the npk, ntr, Ψpk − pk and Ψtr − tr measures on the tessellated CMB map with patches of 7.52 deg2 size prove statistical isotropy in the Planck maps. The peak clustering analysis puts the upper bound on the cosmic-string tension, Gμ(up) ≲ 5.59 × 10−7, in SMICA.
A detailed study of X-ray cavities in the intracluster environment of the cool core cluster Abell 3017
Authors: Pandge M B , Sebastian Biny , Seth Ruchika , Raychaudhury Somak 
Published: February 2021

ABSTRACT
We present a detailed analysis of a cool-core galaxy cluster Abell 3017, at a redshift of z = 0.219, which has been identified to be merging with its companion cluster Abell 3016. This study has made use of X-ray (Chandra), ultraviolet (UV) [Galaxy Evolution Explorer(GALEX)], optical [European Southern Observatory (ESO)/very large telescope (VLT)], mid-infrared [(Wide-field Infrared Survey Explorer (WISE)], and radio upgraded Giant Metrewave radio telescope (uGMRT) observations of this cluster. Using various image processing techniques, such as unsharp masking, 2D fits using β models, contour binning and the use of surface brightness profiles, we show the existence of a pair of X-ray cavities, at a projected distance of ∼20 arcsec (70 kpc) and ∼16 arcsec (57 kpc), respectively, from the core of Abell 3017. We also detect an excess of X-ray emission located at ∼25 arcsec (88 kpc) south of the centre of Abell 3017, is likely due to the bulk motions in the intracluster medium either by gas sloshing or ram-pressure striping due to a merger. We find that the radio lobes are responsible for the observed X-ray cavities detected in this system. The lower values of mid-infrared WISE colour [W1–W2] and [W2–W3] imply that the central BCG of Abell 3017 is a star-forming galaxy. The current star formation rate of the central BCG, estimated from the H α and GALEX far-ultraviolet (FUV) luminosities, are equal to be ∼5.06 ± 0.78 and ∼9.20 ± 0.81 $\rm M_{\odot }$ yr−1, respectively. We detect, for the first time, a radio phoenix ∼150 kpc away from the radio core, with a spectral index of (α ≤ −1.8). We also report the detection of $\rm ~Pa\,\alpha$ emission in this cluster using ESO VLT SINFONI imaging data.
UVIT-HST-Gaia-VISTA study of Kron 3 in the Small Magellanic Cloud: a cluster with an extended red clump in ultraviolet
Authors: Nayak P K , Subramaniam A , Subramanian S , Sahu S , Mondal C , Cioni Maria-Rosa L , Bell Cameron P M , Bandyopadhyay A , Chung Chul 
Published: February 2021

ABSTRACT
We have demonstrated the advantage of combining multiwavelength observations, from the ultraviolet (UV) to near-infrared, to study Kron 3, a massive star cluster in the Small Magellanic Cloud. We have estimated the radius of the cluster Kron 3 to be 2.0 arcmin and for the first time, we report the identification of NUV-bright red clump (RC) stars and the extension of the RC in colour and magnitude in the NUVversus (NUV–optical) colour–magnitude diagram (CMD). We found that extension of the RC is an intrinsic property of the cluster and it is not due to contamination of field stars or differential reddening across the field. We studied the spectral energy distribution of the RC stars, and estimated a small range in temperature ∼5000–5500 K, luminosity ∼60–90 L⊙, and radius ∼8.0–11.0 R⊙ supporting their RC nature. The range of UV magnitudes amongst the RC stars (∼23.3–24.8 mag) is likely caused by the combined effects of variable mass-loss, variation in initial helium abundance (Yini = 0.23–0.28), and a small variation in age (6.5–7.5 Gyr) and metallicity ([Fe/H] = −1.5 to −1.3). Spectroscopic follow-up observations of RC stars in Kron 3 are necessary to confirm the cause of the extended RC.
Extracting H i astrophysics from interferometric intensity mapping
Authors: Chen Zhaoting , Wolz Laura , Spinelli Marta , Murray Steven G 
Published: February 2021

ABSTRACT
We present a new halo model of neutral hydrogen (H i) calibrated to galaxy formation simulations at redshifts z ∼ 0.1 and z ∼ 1.0 that we employ to investigate the constraining power of interferometric H i intensity mapping on H i astrophysics. We demonstrate that constraints on the small-scale H i power spectrum can break the degeneracy between the H i density $\Omega _{\rm H\, \small {I}}$ and the H i bias $b_{\rm H\, \small {I}}$. For z ∼ 0.1, we forecast that an accurate measurement of $\Omega _{\rm H\, \small {I}}$ up to 6 per cent level precision and the large-scale H i bias $b_{\rm H\, \small {I}}^0$ up to 1 per cent level precision can be achieved using Square Kilometre Array (SKA) pathfinder data from MeerKAT and Australian SKA Pathfinder (ASKAP). We also propose a new description of the H i shot noise in the halo model framework in which a scatter of the relation between the H i mass of galaxies and their host halo mass is taken into account. Furthermore, given the number density of H i galaxies above a certain H i mass threshold, future surveys will also be able to constrain the H i mass function using only the H i shot noise. This will lead to constraints at the 10 per cent level using the standard Schechter function. This technique will potentially provide a new way of measuring the H i mass function, independent from existing methods. We predict that the SKA will be able to further improve the low-redshift constraints by a factor of 3, as well as pioneering measurements of H i astrophysics at higher redshifts.
28–40 GHz variability and polarimetry of bright compact sources in the QUIJOTE cosmological fields
Authors: Perrott Yvette C , López-Caniego Marcos , Génova-Santos Ricardo T , Rubiño-Martín Jose Alberto , Ashdown Mark , Herranz Diego , Lähteenmäki Anne , Lasenby Anthony N , López-Caraballo Carlos H , Poidevin Frédérick , Tornikoski Merja 
Published: February 2021

ABSTRACT
We observed 51 sources in the Q-U-I JOint TEnerife (QUIJOTE) cosmological fields that were brighter than 1 Jy at 30 GHz in the Planck Point Source Catalogue (version 1), with the Very Large Array at 28–40 GHz, in order to characterize their high-radio-frequency variability and polarization properties. We find a roughly lognormal distribution of polarization fractions with a median of 2 per cent, in agreement with previous studies, and a median rotation measure (RM) of ≈1110 rad m−2 with one outlier up to ≈64 000 rad m−2, which is among the highest RMs measured in quasar cores. We find hints of a correlation between the total intensity  flux density and median polarization fraction. We find 59 per cent of sources are variable in total intensity, and 100 per cent in polarization at 3σ level, with no apparent correlation between total intensity variability and polarization variability. This indicates that it will be difficult to model these sources without simultaneous polarimetric monitoring observations and they will need to be masked for cosmological analysis.