bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rationale and Trial Design of MesEnchymal Stem Cell Trial in Preventing Venous Stenosis of Hemodialysis Vascular Access Arteriovenous Fistula (MEST AVF Trial)
Authors: Piryani Ameet K. , Kilari Sreenivasulu , Takahashi Edwin , DeMartino Randall R. , Mandrekar Jay , Dietz Allan B. , Misra Sanjay 
Published: September 2021

Key Points

At 1 year after placement, 60% of hemodialysis arteriovenous fistulas (AVF) will develop venous neointimal hyperplasia (VNH) and subsequent venous stenosis (VS).Autologous adipose-derived mesenchymal stem cells may help reduce VS formation associated with hemodialysis AVF.There are no therapies available to prevent VS formation associated with hemodialysis AVF.

Background
Hemodialysis arteriovenous fistulas (AVFs) are the preferred vascular access for patients on hemodialysis. In the Hemodialysis Fistula Maturation Study, 44% of the patients achieved unassisted maturation of their fistula without needing an intervention. Venous neointimal hyperplasia (VNH) and subsequent venous stenosis are responsible for lack of maturation. There are no therapies that can prevent VNH/VS formation. The goal of this paper is to present the background, rationale, and trial design of an innovative phase 1/2 clinical study that is investigating the safety of autologous adipose-derived mesenchymal stem cells delivered locally to the adventitia of newly created upper extremity radiocephalic (RCF) or brachiocephalic fistula (BCF).

Methods
The rationale and preclinical studies used to obtain a physician-sponsored investigational new drug trial are discussed. The trial design and end points are discussed.

Results
This is an ongoing trial that will complete this year.

Conclusion
This is a phase 1/2 single-center, randomized trial that will investigate the safety and efficacy of autologous AMSCs in promoting maturation in new upper-extremity AVFs.

Clinical Trial registration number: NCT02808208
Konsumsi minuman berpemanis kemasan pada remaja
Authors: Sari Septi Lidya , Utari Diah Mulyawati , Sudiarti Trini 
Published: September 2021

Latar Belakang: Minuman berpemanis kemasan merupakan jenis minuman padat kalori dan tinggi gula, namun rendah nilai gizi. Konsumsi minuman berpemanis secara berlebihan dapat meningkatkan risiko terjadinya penyakit tidak menular, seperti obesitas, diabetes melitus tipe II, dan penyakit kardiovaskular. Tujuan: Penelitian ini bertujuan untuk mengetahui proporsi konsumsi minuman berpemanis kemasan dan mengetahui apakah terdapat perbedaan proporsi konsumsi minuman berpemanis kemasan berdasarkan karakteristik individu dan penggunaan label informasi nilai gizi (ING) pada kalangan remaja. Metode: Desain studi yang digunakan, yaitu cross sectional dengan jumlah responden sebanyak 167 siswa kelas X dan XI pada salah satu SMA swasta (SMAS) di Jakarta Timur. Data diperoleh melalui pengisian kuesioner online dan Semi Quantitative Food Frequency Questionnaire (SQ-FFQ) secara mandiri. Data dianalisis secara univariat dan bivariat dengan uji Chi-Square. Hasil: Tingkat konsumsi minuman berpemanis kemasan pada sebagian besar responden (55,1%) tergolong tinggi (≥3 kali per hari). Hasil analisis bivariat menunjukkan bahwa terdapat perbedaan yang bermakna proporsi konsumsi minuman berpemanis kemasan berdasarkan jenis kelamin (p=0,03) dan kemampuan membaca label ING (p=0,011). Kesimpulan: Tingkat konsumsi minuman berpemanis kemasan cenderung lebih tinggi pada responden laki-laki dan juga pada responden dengan kemampuan membaca label ING rendah.
Hydration process of β-MoO3 powder prepared by pulsed wire discharge method
Authors: Ngo Chu Minh , Hieu Nguyen Duy , Do Thi Mai Dung , Nakayama Tadachika , Niihara Koichi , Suematsu Hisayuki 
Published: September 2021

Abstract
The hydration of β-MoO3 and α-MoO3 powders was investigated through powder exposure experiments at 24 ℃ in the air with a relative humidity of 53%. X-ray diffraction results showed a hydrated phase of MoO3·0.34H2O in only exposed β-MoO3 powder, while the α-MoO3 powder maintained its initial phase. By thermogravimetry-differential thermal analysis and mass spectrometry measurements and the dehydration experiments, the stable temperature range of the hydrated phase made by β-MoO3 was identified below 285 °C, and above this temperature, the hydrated phase transformed back to the original β-MoO3 phase. The other analysis methods using field-emission scanning electron microscopy and field-emission transmission electron microscopy were also used to determine powders’ morphology and size and to confirm phases from their lattice images. To the best of our knowledge, this is the first report on the formation of the hydrated phase by exposing β-MoO3 powder in the humid air.
SARS-COV-2 como desencadenante de enfermedades tromboembólicas en el embarazo
Authors: Barrera García Kenneth Andersson 
Published: September 2021

OBJETIVO: Describir el SARS-COV-2 como desencadenante de enfermedades tromboembólicas en el embarazo MÉTODO: Se recopiló información de artículos de revistas científicas y metaanálisis. RESULTADOS: Durante la pandemia en el país de Chile se realizaron muestras de PCR, exámenes para detectar el virus (89,2%) fueron mujeres gestantes. Se identificaron patologías asociadas como Hipertensión en el 9,7% y pacientes con Diabetes Mellitus 1 o 2 en un 8.3%, enfermedades tromboembólicas en un mismo porcentaje. CONCLUSIÓN: Actualmente, la infección por SARS-CoV-2 es una afección en la cual el daño endotelial y la interacción entre factores inflamatorios y tromboticos, posee una característica única, mediada por citoquinas y leucocitos, estableciendo una activación global en la cascada de coagulación, generando la trombosis masiva provocando tromboembolia pulmonar y trombosis venosa profunda, Se reconoce como un gran reto la prevención del Tromboembolismo Venoso, siempre se debe tener en cuenta, los 3 conceptos iniciales siguientes: “conocer factores de riesgo, realizar un diagnóstico oportuno e indicar el tratamiento profiláctico adecuado”, todas estas gestiones están directamente relacionadas y como principal objetivo la disminución de la mortalidad materna.
Factores determinantes de fotosensibilidad y dermatosis más frecuentes
Authors: Rodríguez Lémus Katherine Dariana 
Published: September 2021

En las enfermedades de la piel intervienen muchos factores fotosensibles y pueden llegar a causar lesiones agravantes en la epidermis, hasta causar riegos graves como el cáncer; y las altas tasas de exposición al sol, emiten una amplia cantidad de radiaciones electromagnéticas, pero las más importantes desde el punto de vista dermatológico, son las que pertenecen al espectro fotobiológico porque causan lesiones cutáneas (fotodermatosis). En general, parecen estar aumentando notablemente en los últimos años en todo el mundo, debido a la tendencia de las modificaciones ambientales provocadas por la contaminación, y ahora es uno de los principales o más consultado problema en salud pública en el mundo. Las organizaciones mundiales de la salud realizan investigaciones con el objetivo de obtener el índice UV más alto donde la ubicación geográfica es un importante determinante para la intensidad de los rayos UV, y su asociación con las enfermedades actínicas agudas de piel. Entre las dermatosis más comunes se mencionan: la urticaria solar, hydroa vacciniforme, erupción polimorfa lumínica, prurigo actínico, dermatitis actínica crónica, por lo cual se determina que la mayoría de pacientes con afecciones por dermatosis, se mantienen en constante exposición a la luz solar, provocando daño y alteración a la estructura de la epidermis, por lo que se puede encontrar una patología de tipo crónico, según el lapso de tiempo de exposición.
Organizasyonel Sessizlik, Düşüş ve Ölüm
Authors: ŞENGÖZ Murat 
Published: September 2021

Organizasyonların varlıklarını devam ettirebilmek için başa çıkmaları gereken koşullar ve diğer zorluklarla mücadelelerinde veya çevreye adaptasyonlarında başarılı olamamaları, organizasyonların varlıklarının sona ermesine neden olabilir. Organizasyonlar, yapıları ve işleyişleri, teknik ve insani unsurları ile bir yandan teknik rasyonellik sağlamaya, diğer yandan da insan unsurları ile bir bütün olarak çevrelerine uyum sağlamaya ve varlıklarını devam ettirmeye çalışırlar. Bu yönüyle organizasyonlar, yaşayan birer varlık olarak doğarlar, gelişirler ve ölürler. Bu çalışmada organizasyonların sessizliği, düşüşü ve ölümü yani varlıklarının sona ermesiyle ilgili akademik literatür derlenecektir. Bu çalışmada organizasyonel sessizlik, düşüş ve ölüm kavramları hem anılan yönetim ve örgüt yazınında dolaylı olarak, hem de yabancı yazında doğrudan aktarıldığı şekliyle tanımı, süreci, kaynakları ve sonucu itibariyle ele alınacaktır. Bu çerçevede organizasyonel süreklilik çalışmaları ve geliştirilen perspektifler incelenecek, organizasyonların sessizliğe bürünmesi, düşüşleri ve sona ermesinde ayrışan ve birleşen yönler ortaya koyulmaya çalışılacaktır.
Kırsalda Katılım Bankacılığı Algısı: Oltu Örneği
Authors: DİLMAÇ Murat , SUMER Serpil 
Published: September 2021

Bu çalışmada Oltu kırsalında faaliyet gösteren esnafların fon ihtiyaçlarını karşılarken katılım bankalarını tercih edip etmeme durumları ele alınmıştır. Çalışmada veriler anket yöntemi ile elde edilerek SPSS programında analiz edilmiştir. Kategorik değişkenler arasındaki ilişkiyi bulmak için hipotezler oluşturulmuş ve Ki-Kare analizi ile test edilmiştir. Yapılan testler sonucunda medeni durum ile kredi kullanımı arasında ilişki bulunmuş ve kredi kullananlar katılım bankalarının bankacılık sistemi içerisinde yer alması gerektiğini belirtmişlerdir. Ancak hem eğitim durumu ile “kâr payı ve faiz arasında fark olduğu” ifadesi arasında ilişki bulunamamış hem de eğitim durumu ile “katılım bankalarının sisteme dahil edilmesi” arasında ilişki bulunamamıştır. Ayrıca Oltu esnafı katılım bankalarından kredi kullanmayı tercih etmemelerinin nedeni olarak geleneksel bankalarda kredi kullanımının daha kolay olduğunu belirtmişlerdir.
IMPROVEMENT OF REQUIREMENTS FOR THE PRESIDENT OF THE RUSSIAN FEDERATION IN THE CONTEXT OF THE CONSTITUTIONAL REFORM 2020
Authors: Шпехт Любовь Ивановна 
Published: September 2021

В данной статье проанализировано изменение правового статуса Федерального Собрания Российской в контексте принятия поправок в Конституцию РФ 2020 года. Конституционная реформа привела к расширению полномочий палат Федерального собрания, данное явление обусловлено рядом причин рассмотренных автором.
This article analyzes the change in the requirements for the President of the Russian Federation in the mechanism for adopting amendments to the Constitution of the Russian Federation in 2020. The constitutional reform introduced additional restrictive requirements for candidates for President of the Russian Federation, due to a number of reasons considered by the author.
THE ROLE OF DEFENDER IN THE PRODUCTION OF SEPARATE INVESTIGATIVE ACTIONS AT THE PRELIMINARY INVESTIGATION STAGE
Authors: Кузин Ярослав Александрович , Фантров Павел Петрович 
Published: September 2021

Актуальность темы исследования заключается в том, что на сегодняшний день отсутствует единое мнение ученых-процессуалистов относительно роли защитника при производстве следственных действий на стадии предварительного расследования. В статье охарактеризовано участие защитника в контексте проведении некоторых следственных действий - обыск, предъявление для опознания, допрос и производство судебной экспертизы.
The relevance of the research topic lies in the fact that today there is no consensus among procedural scientists regarding the role of the defense attorney in the conduct of investigative actions at the stage of preliminary investigation. The article describes the participation of a defense attorney in the context of certain investigative actions - search, presentation for identification, interrogation and forensic examination.
Evidence for a Nondichotomous Solution to the Kepler Dichotomy: Mutual Inclinations of Kepler Planetary Systems from Transit Duration Variations
Authors: Millholland Sarah C. , He Matthias Y. , Ford Eric B. , Ragozzine Darin , Fabrycky Daniel , Winn Joshua N. 
Published: September 2021

Abstract
Early analyses of exoplanet statistics from the Kepler mission revealed that a model population of multiplanet systems with low mutual inclinations (∼1°–2°) adequately describes the multiple-transiting systems but underpredicts the number of single-transiting systems. This so-called “Kepler dichotomy” signals the existence of a subpopulation of multiplanet systems possessing larger mutual inclinations. However, the details of these inclinations remain uncertain. In this work, we derive constraints on the intrinsic mutual inclination distribution by statistically exploiting transit duration variations (TDVs) of the Kepler planet population. When planetary orbits are mutually inclined, planet–planet interactions cause orbital precession, which can lead to detectable long-term changes in transit durations. These TDV signals are inclination sensitive and have been detected for roughly two dozen Kepler planets. We compare the properties of the Kepler-observed TDV detections to TDV detections of simulated planetary systems constructed from two population models with differing assumptions about the mutual inclination distribution. We find strong evidence for a continuous distribution of relatively low mutual inclinations that is well characterized by a power-law relationship between the median mutual inclination (

μ

˜

i
,
n

) and the intrinsic multiplicity (n):

μ

˜

i
,
n

=

μ

˜

i
,
5

(
n

/

5
)

α

, where

μ

˜

i
,
5

=

1.10

−
0.11

+
0.15

and

α
=
−

1.73

−
0.08

+
0.09

. These results suggest that late-stage planet assembly and possibly stellar oblateness are the dominant physical origins for the excitation of Kepler planet mutual inclinations.
Constraining Mornings and Evenings on Distant Worlds: A new Semianalytical Approach and Prospects with Transmission Spectroscopy
Authors: Espinoza Néstor , Jones Kathryn 
Published: September 2021

Abstract
The technique of transmission spectroscopy—the variation of a planetary radius with wavelength due to opacity sources in the planet’s terminator region—has been one of the most successful in the characterization of exoplanet atmospheres to date, providing key insights into the composition and structure of these distant worlds. A common assumption made when using this technique, however, is that the variations are the same in the entire terminator region. In reality, the morning and evening terminators might have distinct temperature, pressure, and thus compositional profiles due to the inherent 3D nature of the planet, which would, in turn, give rise to different spectra on each side of it. Constraining those might be fundamental for our understanding of not only the weather patterns in these distant worlds but also the planetary formation signatures that might only be possible to extract once these features are well understood. Motivated by this physical picture, in this work, we perform a detailed study of the observational prospects of detecting this effect. We present an open-source semianalytical framework with which this information can be extracted directly from transit light curves and perform a detailed study of the prospects of detecting the effect with current missions, such as TESS, and upcoming ones, such as JWST. Our results show that these missions show great promise for the detection of this effect. Transmission spectroscopy studies with JWST, in particular, could provide spectra of each of the limbs, allowing us to convey 3D information previously accessible only via phase curves.
Vanmanenia marmorata, a new species of loach (Teleostei: Gastromyzontidae) from the middle Chang-Jiang Basin in Guizhou Province, south China
Authors: Deng Shuqing , Zhang E 
Published: September 2021

The gastromyzontid genusVanmaneniawas established by Hora in 1932, based on the type speciesVanmanenia stenosoma. The genus is a loach group adapted to running waters of streams from southern China, northern Vietnam and Laos. Currently, 19 valid species of the genus have been recognised. The northernmost distribution of the genus is the Yangtze River (= Chang-Jiang in Chinese) Basin and five species (V. maculata,V. intermedia,V. stenosoma,V. pseudostriataandV. gymnetrus) have been reported from the Basin.Vanmanenia marmorata, a new hillstream species of loach, is here described from the middle Chang-Jiang Basin in Guizhou Province, south China. It is distinguished from its congeners by having a combination of the following characters: three triangular-shaped rostral lobules; postdorsal saddles wider than interspaces; a more backwards-placed anus (the vent to anal distance 30.5–36.9% of the pelvic to anal distance); a larger gill opening with its upper extremity reaching the level of the middle of the orbit; anal-fin base length 5.6–6.4% of SL; caudal-peduncle length 11.6–12.9% of SL; prepelvic length 51.1–53.4% of SL. Its validity is also affirmed by its distinct cyt b gene sequence divergence with all sampled congeners and its monophyly recovered in a cyt b gene-based phylogenetic analysis.
Effects of Iron Supplements on Heme Scavengers in Pregnancy
Authors: Nti Annette M. , Botchway Felix , Salifu Hassana , Cespedes Juan Carlos , Harbuzariu Adriana , Onyekaba John , Chambliss Christopher , Liu Mingli , Adjei Andrew , Jolly Pauline , Stiles Jonathan K. 
Published: September 2021

ABSTRACT.
In malaria endemic countries, anemia in pregnant women occurs as a result of erythrocyte destruction by Plasmodium infections and other causes including malnutrition. Iron supplementation is recommended as treatment of iron-deficiency anemia. Erythrocyte destruction results in increased release of cytotoxic free heme that is scavenged by haptoglobin (Hp), hemopexin (Hx) and heme oxygenase-1 (HO-1). Paradoxically, iron supplementation in pregnant women has been reported to enhance parasitemia and increase levels of free heme. The relationship between free heme, heme scavengers, and birth outcomes has not been investigated, especially in women who are on iron supplementation. We hypothesized that parasite-infected pregnant women on routine iron supplementation have elevated heme and altered expression of heme scavengers. A cross-sectional study was conducted to determine the association between plasma levels of free heme, HO-1, Hp, Hx, and malaria status in pregnant women who received routine iron supplementation and their birth outcomes. Heme was quantified by colorimetric assay and scavenger protein concentration by ELISA. We demonstrated that iron-supplemented women with asymptomatic parasitemia had increased free heme (mean 75.6 µM; interquartile range [IQR] 38.8–96.5) compared with nonmalaria iron-supplemented women (mean 34.9 µM; IQR 17.4–43.8, P < 0.0001). Women with preterm delivery had lower levels of Hx (mean 656.0 µg/mL; IQR 410.9–861.3) compared with women with full-term delivery (mean: 860.9 µg/mL; IQR 715.2–1055.8, P = 0.0388). Our results indicate that iron supplementation without assessment of circulating levels of free heme and heme scavengers may increase the risk for adverse pregnancy outcomes.
Knowledge, Perceptions, and Attitudes Regarding Antibiotic Use for Lower Respiratory Tract Infections: Insights from Patients in Sri Lanka
Authors: van Melle David T. , ten Asbroek Guus , Rolfe Robert , Vanderburg Sky , Abeysinghe Yohanna W. , Halloluwa Chathuh , Zhang Helen L. , Ostbye Truls , Kurukulasooriya Ruvini , Sheng Tianchen , Kanchana Sewwandi , Wijayaratne Gaya , Bodinayake Champica , Nagahawatte Ajith , Watt Melissa H. , Woods Christopher W. , de Silva Vijitha , Tillekeratne Gayani 
Published: September 2021

ABSTRACT.
Antibiotic resistance is an emerging global public health threat. One of the main drivers of this threat is the inappropriate use of antibiotics. In Sri Lanka, antibiotic consumption is increasing, but little is known locally about how patients perceive antibiotics. We conducted a qualitative study to gain a better understanding of the knowledge, perceptions, and attitudes of patients regarding antibiotics and antibiotic resistance. Semi-structured interviews involving 18 patients with lower respiratory tract infection (LRTI) admitted to a large, public tertiary care hospital in southern Sri Lanka were conducted. Interviews were analyzed to identify themes regarding the patients’ knowledge of LRTI etiology and treatment, perceptions and attitudes toward LRTI treatment, including antibiotics, and patient–physician communication. Most patients mentioned multiple care visits and the use of multiple pharmaceuticals prior to admission. Patients sought a quick resolution to their ailments and frequently visited several private physicians to obtain a satisfying answer. Self-medication was also common. Patients reused prescriptions for antibiotics, kept antibiotics for later use after prematurely stopping their course of treatment, and bought over-the-counter antibiotics. Patients’ knowledge of disease etiology and antibiotics was poor. Only a few patients were aware of antibiotic resistance. Despite the desire to receive more information regarding disease and treatment, patient–provider communication was limited and mainly confined to prescription instructions. This qualitative study performed in Sri Lanka suggests that inappropriate use of antibiotics is a multifactorial problem. To improve antibiotic use, a multifactorial approach that includes educating the public, increasing awareness among physicians, and implementing systems-level changes to restrict access to antibiotics is urgently needed.
Preliminary Report of the Insecticide Susceptibility Status of Aedes albopictus in Bangladesh
Authors: Al-Amin Hasan Mohammad , Irish Seth , Lenhart Audrey , Alam Mohammad Shafiul 
Published: September 2021

ABSTRACT.
Aedes albopictus is a highly invasive mosquito species and a vector of human arboviral diseases including dengue, chikungunya, and Zika. There are no effective drugs or vaccines for the treatment or prevention of most of these diseases, so the primary option for disease prevention and control is to target mosquitoes, often using insecticides. Despite vector control efforts, cases of arboviral diseases are increasing in Bangladesh and it is important to understand if this escalation is associated with the presence of insecticide resistance in Aedes populations, including Ae. albopictus. The CDC bottle bioassays performed on Ae. albopictus from two districts in Bangladesh detected resistance to permethrin but susceptibility to deltamethrin, malathion, and bendiocarb. The detection of permethrin resistance is worrisome, since arbovirus vector control strategies in Bangladesh currently include the use of permethrin. Routine monitoring of the susceptibility status of key vector populations in Bangladesh will allow a better understanding of resistance trends, enabling the strengthening of control strategies.