bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lactoferrin affects rhinovirus B-14 entry into H1-HeLa cells
Authors: Denani Caio Bidueira , Real-Hohn Antonio , de Carvalho Carlos Alberto Marques , Gomes Andre Marco de Oliveira , Gonçalves Rafael Braga 
Published: February 2021

AbstractLactoferrin is part of the innate immune system, with antiviral activity against numerous DNA and RNA viruses. Rhinoviruses, the leading cause of the common cold, are associated with exacerbation of respiratory illnesses such as asthma. Here, we explored the effect of bovine lactoferrin (BLf) on RV-B14 infectivity. Using different assays, we show that the effect of BLf is strongest during adhesion of the virus to the cell and entry. Tracking the internalisation of BLf and virus revealed a degree of colocalisation, although their interaction was only confirmed in vitro using empty viral particles, indicating a possible additional influence of BLf on other infection steps.
A structured pathway for developing your complex abdominal hernia service: our York pathway
Authors: Smith O. , MacLeod T. , Lim P. , Chitsabesan P. , Chintapatla S. 
Published: February 2021

Abstract
Purpose
Clinical pathways are widely prevalent in health care and may be associated with increased clinical efficacy, improved patient care, streamlining of services, while providing clarity on patient management. Such pathways are well established in several branches of healthcare services but, to the authors’ knowledge, not in complex abdominal wall reconstruction (CAWR). A stepwise, structured and comprehensive approach to managing complex abdominal wall hernia (CAWH) patients, which has been successfully implemented in our practice, is presented.

Methods
A literature search of common databases including Embase® and MEDLINE® for CAWH pathways identified no comprehensive pathway. We therefore undertook a reiterative process to develop the York Abdominal Wall Unit (YAWU) through examination of current evidence and logic to produce a pragmatic redesign of our own pathway. Having introduced our pathway, we then performed a retrospective analysis of the complexity and number of abdominal wall cases performed in our trust over time.

Results
We describe our pathway and demonstrate that the percentage of cases and their complexity, as defined by the VHWG classification, have increased over time in York Abdominal Wall Unit.

Conclusion
A structured pathway for complex abdominal wall hernia service is one way to improve patient experience and streamline services. The relevance of pathways for the hernia surgeon is discussed alongside this pathway. This may provide a useful guide to those wishing to establish similar personalised pathways within their own units and allow them to expand their service.
Sweetness profiles of glycosylated rebaudioside A and its binary mixtures with allulose and maltitol
Authors: Jung Jinsil , Kim SooHyun , Park Sunghee , Hong Jae-Hee 
Published: February 2021

AbstractRebaudioside A is a promising natural alternative sweetener but they produce increased bitterness, astringency, and unpleasant aftertastes. Glycosylation and blending with different sweeteners are known to improve the sensory characteristics of rebaudioside A. The present study was conducted to identify the relative sweetness and sensory profile of glycosyl rebaudioside A (g-reb A). The relative sweetness of g-reb A compared to 5% sucrose was determined using the two-alternative forced choice method. The sensory profiles of g-reb A and its mixtures with allulose and maltitol (1:1 ratio) were compared to those of rebaudioside A, rebaudioside D, rebaudioside M, sucralose, allulose, maltitol, and sucrose using descriptive analysis conducted by eight trained panelists. The relative sweetness of g-reb A was 155, which was lower than that of rebaudioside A. In addition, the bitter taste and aftertaste, astringency, and sweet onset of g-reb A were decreased compared to those of rebaudioside A.
Extraction of volatile organic compounds from leaves of Ambrosia artemisiifolia L. and Artemisia annua L. by headspace-solid phase micro extraction and simultaneous distillation extraction and analysis by gas chromatography/mass spectrometry
Authors: Son Ji Hyeon , Islam Md Atikul , Hong Joon Ho , Jeong Ji Young , Song Ok Yeon , Kim Hui Eun , Khan Naeem , Jamila Nargis , Kim Kyong Su 
Published: February 2021

AbstractThis study was designed to analyze the volatile organic compounds in the leaves of Ambrosia artemisiifolia L. and Artemisia annua L. from Korea. For extraction of volatile compounds, headspace-solid phase micro extraction (HS-SPME) and simultaneous distillation extraction (SDE) were applied and analyzed by gas chromatography/mass spectrometry (GC/MS). From the results, SDE extraction was found to give the highest concentration of volatile compounds with an average concentration of 1,237.79 mg/kg for A. annua L. leaves compared to 1,122.73 mg/kg by HS-SPME technique. A total of 116 volatile organic compounds were identified, including 76 similar volatile organic compounds detected by both the methods of extraction in leaves of subject species at varying concentrations. Among these 33 volatile organic compounds were reported for the first time from the subject plant species. Thus the present research findings extend the characterization of volatile organic compounds from leaves of A. annua L. and A. artemisiifolia L. species and reported some distinguishing compounds which may be used for their discrimination.
Fast-track identification of CTX-M-extended-spectrum-β-lactamase- and carbapenemase-producing Enterobacterales in bloodstream infections: implications on the likelihood of deduction of antibiotic susceptibility in emergency and internal medicine departments
Authors: Boattini Matteo , Bianco Gabriele , Iannaccone Marco , Ghibaudo Davide , Almeida André , Cavallo Rossana , Costa Cristina 
Published: February 2021

AbstractThis study aims at presenting a reliable fast-track diagnostics for the detection of CTX-M ESBL- (CTX-M-p) and carbapenemase-producers (CA-p) directly from blood cultures (BCs) of patients with Enterobacterales (EB) bloodstream infections (BSIs) admitted in emergency and internal medicine departments and its contribution in estimation of in vitro antibiotic susceptibility. A fast-track workflow including MALDI-TOF species identification and two lateral flow immunochromatographic assays for the detection of CTX-M-p and CA-p directly from BCs was performed in parallel with conventional routine, and results were compared. A total of 236 BCs of patients suffering from EB BSI were included. Accuracy of the fast-track workflow ranged from 99.6 to 100%. Among E. coli isolates, CTX-M-p (20.5%) were susceptible to ceftolozane-tazobactam (C/T, 97%), ceftazidime-avibactam (CZA, 100%), and piperacillin-tazobactam (TZP, 84.8%), whereas CTX-M-and-main-carbapenemases-non-producer (CTX-M-CA-np, 79.5%) isolates were susceptible to all the antibiotics tested. Among K. pneumoniae isolates, CTX-M-p (23.3%) were poorly susceptible to TZP (40%) but widely susceptible to C/T (90%), CZA (100%), and amikacin (90%), whereas CTX-M-CA-np (55.8%) were also susceptible to cefepime. CA-p K. pneumoniae (20.9%) were susceptible to CZA (88.9%). All the species other than E. coli and K. pneumoniae were CTX-M-CA-np and were widely susceptible to the antibiotics tested except for isolates of the inducible and derepressed AmpC- or AmpC/ESBL-p species. Rapid identification of species and phenotype together with knowledge of local epidemiology may be crucial to determine the likelihood of deduction of in vitro antibiotic susceptibility on the same day of positive BC processing.
Competence-based assignment of tasks to workers in factories with demand-driven manufacturing
Authors: Staruch Bożena , Staruch Bogdan 
Published: February 2021

AbstractThe paper is motivated by real problems concerning tasks assignment to workers in medium-sized upholstered furniture plants managed using the Demand-Driven Manufacturing. Although the methodology was developed for furniture plants it can be applied to other types of production plants. We involve competence coefficients, which describe the level of the worker’s skills or capabilities to perform a specific task. The competence coefficients are also used to block the possibility of assigning the given task to a worker that has no skills to do it. Additionally, we involve a dummy worker to the model which guarantees the existence of a solution to the problem. We present and discuss Integer Linear Programming Models for the posted problem that are closely related to the Generalized Assignment Problem. We also discuss the potential use of the presented methodology to solve real-life problems related to production management.
A systematic review of the quality of reporting of interventions in the surgical treatment of Crohn’s anal fistula: an assessment using the TIDiER and Blencowe frameworks
Authors: Tyrell S. , Coates E. , Brown Steven R. , Lee M. J. 
Published: February 2021

Abstract
Background
Crohn’s anal fistula is a challenging condition, and may require multiple surgical procedures. To replicate successful procedures, these must be adequately reported in the literature. The aim of this study was to review the quality of reporting of components of surgical interventions for Crohn’s anal fistula.

Methods
A systematic review was conducted. It was registered with PROSPERO (CRD:42019135157). The Medline and EMBASE databases were searched for studies reporting interventions intended to close fistula in patients with Crohn’s disease, published between 1999 and August 2019. Abstracts and full texts were screened for inclusion by two reviewers. Dual extraction of data was performed to compare reporting to the TIDiER and Blencowe frameworks for reporting of interventions.

Results
Initial searches identified 207 unique studies; 38 full texts were screened for inclusion and 33 were included. The most common study design was retrospective cohort (17/33), and the most frequently reported interventions were anal fistula plug (n = 8) and fibrin glue (n = 6). No studies showed coverage of all domains of TIDieR. Reporting was poor among domains related to who provided an intervention, where it was provided, and how it was tailored. Reporting of domains in the Blencowe framework was poor; the majority of studies did not report the component steps of procedures or efforts to standardise them.

Conclusions
This study demonstrates that reporting on technical aspects of interventions for Crohn’s anal fistula is poor. Surgeons should aim to improve reporting to allow accurate reproduction of techniques both in clinical practice and in clinical trials.
Model-driven engineering city spaces via bidirectional model transformations
Authors: Visconti Ennio , Tsigkanos Christos , Hu Zhenjiang , Ghezzi Carlo 
Published: February 2021

AbstractEngineering cyber-physical systems inhabiting contemporary urban spatial environments demands software engineering facilities to support design and operation. Tools and approaches in civil engineering and architectural informatics produce artifacts that are geometrical or geographical representations describing physical spaces. The models we consider conform to the CityGML standard; although relying on international standards and accessible in machine-readable formats, such physical space descriptions often lack semantic information that can be used to support analyses. In our context, analysis as commonly understood in software engineering refers to reasoning on properties of an abstracted model—in this case a city design. We support model-based development, firstly by providing a way to derive analyzable models from CityGML descriptions, and secondly, we ensure that changes performed are propagated correctly. Essentially, a digital twin of a city is kept synchronized, in both directions, with the information from the actual city. Specifically, our formal programming technique and accompanying technical framework assure that relevant information added, or changes applied to the domain (resp. analyzable) model are reflected back in the analyzable (resp. domain) model automatically and coherently. The technique developed is rooted in the theory of bidirectional transformations, which guarantees that synchronization between models is consistent and well behaved. Produced models can bootstrap graph-theoretic, spatial or dynamic analyses. We demonstrate that bidirectional transformations can be achieved in practice on real city models.
Early EEG Alterations Correlate with CTP Hypoperfused Volumes and Neurological Deficit: A Wireless EEG Study in Hyper-Acute Ischemic Stroke
Authors: Ajčević Miloš , Furlanis Giovanni , Miladinović Aleksandar , Buoite Stella Alex , Caruso Paola , Ukmar Maja , Cova Maria Assunta , Naccarato Marcello , Accardo Agostino , Manganotti Paolo 
Published: February 2021

AbstractBrain electrical activity in acute ischemic stroke is related to the hypoperfusion of cerebral tissue as manifestation of neurovascular coupling. EEG could be applicable for bedside functional monitoring in emergency settings. We aimed to investigate the relation between hyper-acute ischemic stroke EEG changes, measured with bedside wireless-EEG, and hypoperfused core-penumbra CT-perfusion (CTP) volumes. In addition, we investigated the association of EEG and CTP parameters with neurological deficit measured by NIHSS. We analyzed and processed EEG, CTP and clinical data of 31 anterior acute ischemic stroke patients registered within 4.5 h from symptom onset. Delta/alpha ratio (DAR), (delta + theta)/(alpha + beta) ratio (DTABR) and relative delta power correlated directly (ρ = 0.72; 0.63; 0.65, respectively), while alpha correlated inversely (ρ = − 0.66) with total hypoperfused volume. DAR, DTBAR and relative delta and alpha parameters also correlated with ischemic core volume (ρ = 0.55; 0.50; 0.59; − 0.51, respectively). The same EEG parameters and CTP volumes showed significant relation with NIHSS at admission. The multivariate stepwise regression showed that DAR was the strongest predictor of NIHSS at admission (p < 0.001). The results of this study showed that hyper-acute alterations of EEG parameters are highly related to the extent of hypoperfused tissue highlighting the value of quantitative EEG as a possible complementary tool in the evaluation of stroke severity and its potential role in acute ischemic stroke monitoring.
A generalised complete flux scheme for anisotropic advection-diffusion equations
Authors: Cheng Hanz Martin , Boonkkamp Jan ten Thije 
Published: February 2021

AbstractIn this paper, we consider separating the discretisation of the diffusive and advective fluxes in the complete flux scheme. This allows the combination of several discretisation methods for the homogeneous flux with the complete flux (CF) method. In particular, we explore the combination of the hybrid mimetic mixed (HMM) method and the CF method, in order to utilise the advantages of each of these methods. The usage of HMM allows us to handle anisotropic diffusion tensors on generic polygonal (polytopal) grids, whereas the CF method provides a framework for the construction of a uniformly second-order method, even when the problem is advection dominated.
Space and Place. A Morphological Perspective
Authors: Furia Paolo 
Published: February 2021

AbstractThe morphological account of landscape aims to overcome the contrast between an objectivist/scientific account of space and the more qualitative/subjective account of place. It does so by actualizing the notion of landscape, which endows a materiality often overlooked in contemporary spatial theories. In this paper, I will discuss what has been called the ‘space-place conundrum’ by referring mostly to the human geography contemporary debate on space and place. In the following, I will retrieve Carl Sauer’s morphological conception of landscape as an alternative framework aimed at rephrasing both the concepts of space and place. Landscape must be freed from the cage of the aesthetic gaze so that it can be understood as a lived and dynamic complex of interacting forms that encompass the embodied subject. In the end, I will outline the main characteristics of a morphological conception of landscape, paving the way for further inquiries.
The impact of age on patient-reported outcomes after oncoplastic versus conventional breast cancer surgery
Authors: Ritter M. , Ling B. M. , Oberhauser I. , Montagna G. , Zehnpfennig L. , Lévy J. , Soysal S. D. , Castrezana L. López , Müller M. , Schwab F. D. , Kurzeder C. , Haug M. , Weber W. P. , Kappos E. A. 
Published: February 2021

Abstract
Purpose
Some studies have indicated age-specific differences in quality of life (QoL) among breast cancer (BC) patients. The aim of this study was to compare patient-reported outcomes after conventional and oncoplastic breast surgery in two distinct age groups.

Methods
Patients who underwent oncoplastic and conventional breast surgery for stage I-III BC, between 6/2011–3/2019, were identified from a prospectively maintained database. QoL was prospectively evaluated using the Breast-Q questionnaire. Comparisons were made between women < 60 and ≥ 60 years.

Results
One hundred thirty-three patients were included. Seventy-three of them were ≥ 60 years old. 15 (20.5%) of them received a round-block technique (RB) / oncoplastic breast-conserving surgeries (OBCS), 10 (13.7%) underwent nipple-sparing mastectomies (NSM) with deep inferior epigastric perforator flap (DIEP) reconstruction, 23 (31.5%) underwent conventional breast-conserving surgeries (CBCS), and 25 (34.2%) received total mastectomy (TM). Sixty patients were younger than 60 years, 15 (25%) thereof received RB/OBCS, 22 (36.7%) NSM/DIEP, 17 (28.3%) CBCS, and 6 (10%) TM. Physical well-being chest and psychosocial well-being scores were significantly higher in older women compared to younger patients (88.05 vs 75.10; p < 0.001 and 90.46 vs 80.71; p = 0.002, respectively). In multivariate linear regression, longer time intervals had a significantly positive effect on the scales Physical Well-being Chest (p = 0.014) and Satisfaction with Breasts (p = 0.004). No significant results were found concerning different types of surgery.

Conclusion
Our findings indicate that age does have a relevant impact on postoperative QoL. Patient counseling should include age-related considerations, however, age itself cannot be regarded as a contraindication for oncoplastic surgery.
Adversity Tries Friends: A Multilevel Analysis of Corporate Philanthropic Response to the Local Spread of COVID-19 in China
Authors: Chen Hanwen , Liu Siyi , Liu Xin , Yang Daoguang 
Published: February 2021

AbstractWe examine corporate philanthropic decisions in response to the local spread of COVID-19. From a strategic perspective, firms may proactively undertake philanthropic efforts to limit the spread of the pandemic and avoid a degraded business environment. From the perspective of non-trivial costs, increased economic uncertainty can raise concerns about business survival and lead to conservative philanthropic strategies. Following the proverb “prosperity makes friends, adversity tries them,” at the provincial level, our results support the second perspective. Specifically, when the spread of the pandemic worsens in a province, local firms are less likely to make COVID-19-related donations in terms of likelihood and amount. Investors also react negatively, not only to the local spread of COVID-19 but also to COVID-19-related philanthropic donations. At the organizational level, our evidence indicates that there is at least some level of cost–benefit analysis underlying corporate philanthropic decisions. Specifically, corporate philanthropic donations, especially those made to the local business environment, are significantly affected by organizational-level factors, such as pre-existing resource availability and motives to acquire political and reputational resources. Overall, our multilevel study presents a comprehensive picture of corporate philanthropic decisions amid the COVID-19 crisis.
Re-framing the threat of global warming: an empirical causal loop diagram of climate change, food insecurity and societal collapse
Authors: Richards C. E. , Lupton R. C. , Allwood J. M. 
Published: February 2021

AbstractThere is increasing concern that climate change poses an existential risk to humanity. Understanding these worst-case scenarios is essential for good risk management. However, our knowledge of the causal pathways through which climate change could cause societal collapse is underdeveloped. This paper aims to identify and structure an empirical evidence base of the climate change, food insecurity and societal collapse pathway. We first review the societal collapse and existential risk literature and define a set of determinants of societal collapse. We develop an original methodology, using these determinants as societal collapse proxies, to identify an empirical evidence base of climate change, food insecurity and societal collapse in contemporary society and then structure it using a novel-format causal loop diagram (CLD) defined at global scale and national granularity. The resulting evidence base varies in temporal and spatial distribution of study and in the type of data-driven methods used. The resulting CLD documents the spread of the evidence base, using line thickness and colour to depict density and type of data-driven method respectively. It enables exploration of how the effects of climate change may undermine agricultural systems and disrupt food supply, which can lead to economic shocks, socio-political instability as well as starvation, migration and conflict. Suggestions are made for future work that could build on this paper to further develop our qualitative understanding of, and quantitative complex systems modelling capabilities for analysing, the causal pathways between climate change and societal collapse.
The Bundle Theory Approach to Relational Quantum Mechanics
Authors: Oldofredi Andrea 
Published: February 2021

AbstractThe present essay provides a new metaphysical interpretation of Relational Quantum Mechanics (RQM) in terms of mereological bundle theory. The essential idea is to claim that a physical system in RQM can be defined as a mereological fusion of properties whose values may vary for different observers. Abandoning the Aristotelian tradition centered on the notion of substance, I claim that RQM embraces an ontology of properties that finds its roots in the heritage of David Hume. To this regard, defining what kind of concrete physical objects populate the world according to RQM, I argue that this theoretical framework can be made compatible with (i) a property-oriented ontology, in which the notion of object can be easily defined, and (ii) moderate structural realism, a philosophical position where relations and relata are both fundamental. Finally, I conclude that under this reading relational quantum mechanics should be included among the full-fledged realist interpretations of quantum theory.