bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 20-year-old man with hemopneumothorax caused by penetrating thoracic trauma: a case report
Authors: Chandra David , Edwar Pesta Parulian Maurid 
Published: January 2025

Link of Video Abstract: https://youtu.be/IgxLxMUB4Xk

Background: 20–25% of trauma-related deaths are caused by thoracic injuries, which also contribute to 25–50% of patient deaths. An increasing number of critically injured but potentially salvageable patients are reporting to trauma centers as a result of the rising occurrence of penetrating chest injuries and the advancements in prehospital and perioperative care. Up to 80% of patients with penetrating chest injuries can be treated conservatively; in other situations, a sternotomy/thoracotomy (3%) or tube thoracostomy (18%) may be required. This case report aims to present a case of hemopneumothorax as a consequence of penetrating thoracic trauma.
Case presentation: A 20-year-old male patient referred to Dr. Soetomo General Hospital a tertiary referral hospital massive hemopneumothorax dextra post water seal drainage to be underwent surgical resuscitation by open thoracotomy procedure then right internal mammary ligation and pericardial repair surgery. Patient’s condition steadily improved after the operation. Chest penetrating thoracic trauma caused by applying a mechanical force directly and abruptly to a focused location can cause penetrating injuries. By stretching and crushing tissue, a knife or projectile causes damage, which is often limited to the tissues in the route of penetration. The Patient with significant chest injuries needs to be managed with adequate analgesics and chest physiotherapy.
Conclusion: Clear treatment algorithms and uniform assessment in chest penetrating trauma are essential for effective management. A substantial number of patients can be saved by conducting the primary survey and beginning with interventions that can save patient lives.
Characterization and potential antibacterial activity of green synthesis zinc-oxide nano particles using Physalis angulata linn leaves extract against Staphylococcus aureus
Authors: Kumala Yuliana Ratna , Fitriani Delvi , Adhuri Amyra Rahmi , Zahira Mayladiva Qaniya , Fadia Salma Larasati 
Published: January 2025

Background: Staphylococcus aureus (S. aureus) is widely accepted as one of the etiology of dental caries. The development of nanoparticle-based drugs is necessary to enhance penetration to bacterial cells as well as reduce antimicrobial resistance. Green synthesis nanoparticles using plant compounds are proposed to support the metal structure with fewer toxicities. This study was aimed to evaluate the green synthesis of Zinc-Oxide Nano Particles (ZnONP) using Physalis angulata Linn (P. angulata L) leave extracts and antibacterial analysis against S. aureus.
Methods: Air-dried P. angulata L leaves simplicial were extracted using the maceration method in 70% ethanol solvent. The green synthesis of ZnONP + P. angulata L was confirmed using sequential methods, namely Ultraviolet-Visible (UV-Vis) Spectroscopy, X-ray diffraction (XRD), Energy Dispersive X-ray (EDX), Field Emission Scanning Electron Microscope (FESEM) and Transmission Electron Microscope (TEM) to evaluate the nanoparticle formation, crystallinity phase, size, composition, surface morphology and crystal structure respectively.
Results: The UV-Vis analysis showed a peak of absorbance in the range of 350-400 nm. The EDS revealed Zn as a major metal composition. The XRD analysis confirmed the wurtzite crystal phase with a particle size of 96.38 nm. The FESEM imaging demonstrated mixed morphology of needle-like and nanoflake shapes of ZnONP. The TEM analysis also confirmed the size of nanoparticles as hexagonal crystal structures. The antibacterial test demonstrated the extract concentration of 25% as the minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC).
Conclusion: The ZnONP synthesis using 25% extract of P. angulata L showed a potential antibacterial toward S. aureus growth.
Unemployment worst sleep quality in the elderly at the outpatient clinic of Dr. Soetomo Hospital Surabaya and Airlangga University Hospital Surabaya
Authors: Hamdan Muhammad , Rahmarini Edfina , Islamiyah Wardah Rahmatul 
Published: January 2025

Background: Impaired sleep quality often occurs in the elderly. Most of the elderly are retired or not working. Unemployment makes the elderly get more sleep during the day. So, the elderly have difficulty sleeping at night. This will cause sleep quality disorders in the elderly. The aim of this study was to determine the relationship between unemployment and sleep quality in the elderly.
Methods: This study is a cross-sectional study conducted at the multicenter at the outpatient polyclinic of RSUD Dr. Soetomo and the outpatient polyclinic at the Airlangga University Hospital, Surabaya. Each subject who entered this study will fill out the identity questionnaire to measure unemployment and the PSQI questionnaire to measure sleep quality. This study was approved by the ethics committee of Dr. Soetomo Surabaya Hospital and Airlangga University Surabaya Hospital from Dr. Sutomo Hospital number 0249/KEPK/VIII/2021 and from Universitas Airlangga Hospital number 170/KEP/2021.
Results: We collected data from 345 subjects treated at the outpatient polyclinic of Dr. Soetomo Hospital Surabaya and Airlangga University Hospital Surabaya. It was found that 236(68.4%) subjects were in the unemployment category;109 (31.6%)subjects were still working; 86(24.9%) subjects were in the impaired sleep quality; 259(75.1%) subjects were in good sleep quality. Based on this research, unemployment is statistically significant for the worst sleep quality p 0.020 OR 2.046 CI 95 % (1.147-3.640).
Conclusion: Unemployment influences sleep quality in the elderly at the outpatient polyclinic of RSUD Dr. Soetomo and Airlangga University Hospital Surabaya.
In-vivo and in-silico immunomodulator activity of Caesalpinia sappan L. wood ethanol extract in Rattus norvegicus infected by E. coli
Authors: Rohmah Martina Kurnia , Anwari Farida , Nurdianto Arif Rahman , Rahayu Dwi Anggorowati , Taniasari Nungky , Susanti Elda 
Published: January 2025

Introduction: Immunomodulators from natural compounds have a good potential in curing infectious diseases including Escherichia coli (E. coli) infection in the gastrointestinal and urinary tract. In Indonesia, Sappan wood (Caesalpinia sappan L.) is known as a traditional herbal drink that can be used to increase immunity. Caesalpinia sappan L. has a specific red natural pigment called brazilin. This study aimed to determine the immunomodulatory activity of Caesalpinia sappan L. in Rattus norvegicus infected with E. coli.
Method: This study was a true experimental with a post-test-only control design (in vivo) that used Rattus norvegicus infected by E. coli (10-9-CFU/ ml). This study consisted of normal control (non-infected group), negative control (placebo), positive control (immune booster), and 96% Ethanol Extract of Sappan Wood (SWEE) 25, 50, 100, and 200 mg/kg BW. The treatment was given for 7 days after E. coli infection. In silico study, we used brazilin as a ligand and pro-inflammatory cytokine (TNFα and IL-1β) as the target. It was conducted using a molecular docking web server (Docking Server).
Results: In vivo study showed that Caesalpinia sappan L. decreased C-reactive protein (CRP) levels and increased phagocytic index. SWEE 100 and 200 mg/kg BW was significantly different from the negative control (p<0.05) but not the positive control (p>0.05). SWEE 100 and 200 mg/kg BW increased phagocytic index by 2.82 and 4.62 folds. The molecular docking showed that brazilin binds to TNF-α, and IL-1β with total energy binding respectively -5.05 and -3.14 kcal/mol. The estimation inhibition constant (Ki) of brazilin into TNF-α and IL-1β respectively 199.52 and 4.99 µM.
Conclusion: Caesalpinia sappan L. has immunomodulatory activity through CRP level suppression and phagocytosis induction, especially at 100 and 200 mg/kg BW. Brazilin as a specific pigment of Caesalpinia sappan L also has been proven to inhibit pro-inflammatory cytokine TNF-α and IL-1β.
Enhancing colorectal cancer treatment efficacy: A comprehensive investigation into the synergistic potential of Phyllanthus niruri Linn and capecitabine in targeting cancer stem cells
Authors: Adrianto Albertus Ari , Riwanto Ignatius , Sadhana Udadi , Paramita Dewi Kartikawati , Setyawan Henry , Tjandra Kevin Christian , Adiningsih Dwi , Pravitha Clarissa Aulia , Mahati Endang 
Published: January 2025

Introduction: Colorectal cancer (CRC) prevalence is rising globally with significant mortality rates. Cancer stem cells (CRC-SC) resist chemotherapy, marked by CD133 and CD44. Immune system involvement and immunosuppression in chronic inflammation impact CRC progression. CD18 and CD8 are crucial in T cell migration and activation. Capecitabine is a common chemotherapy for CRC. Phyllantus niruri Linn exhibits immunomodulatory effects, inducing apoptosis and inhibiting proliferation in colon cancer cell lines. The study aims to assess the effectiveness and safety of combination therapy, correlating outcomes with key biomarkers CD133 and CD8-18, associated with CRC-SCs and T cell proliferation, respectively. Such insights may pave the way for more targeted and effective colorectal cancer treatments, offering hope for improved patient outcomes. Methods: This research was conducted for 4 months using a true experimental research method with a post-test-only control group design. This study used 57 Sprague-Dawley rats which were divided into 5 groups: positive control, negative control, and intervention with Phyllanthus niruri Linn, Xelloda, and combination of Phyllanthus niruri Linn and Xelloda. All groups were subjected to three general procedures: pre-surgery, surgery, and post-surgery.
Results: The findings demonstrated that Phyllanthus niruri Linn had significant activating CTL markes (CD8 and CD-18) compared to the control group (p<0.05). The combination of Phyllanthus niruri Linn and Capecitabine also significantly reduced the stem cell biomarkers (CD133) compared to cancer groups (P<0.05).
Conclusion: The combination of Phyllanthus niruri L extract and Xeloda is proven able to increase the apoptosis of colorectal cancer stem cells.
Advanced ultrasonography techniques for thyroid gland changes in nasopharyngeal carcinoma patients after intensity-modulated radiation therapy in comparison with normal subjects
Authors: Asih Made Widhi , Antari Luh Putu Laksmi , Martono Budi , Nike Felicia , Ratnasari Putri Ayu 
Published: January 2025

Introduction: Radiation therapy to the neck in Nasopharyngeal Carcinoma (NPC) patients could disrupt thyroid function, causing further damage to the thyroid parenchyma and fibrosis. Ultrasonography techniques could detect volume reduction, decreased echogenicity and increased shear-wave elastography. This paper aims to use advanced ultrasonography techniques to measure echogenicity index, color-pixel percentage (CPP), shear-wave elastography (SWE) and volume of the thyroid glands in NPC patients after Intensity-Modulated Radiation Therapy (IMRT) in comparison with normal subjects with an analytical observational study.
Methods: The patients were selected consecutively from medical records of NPC patients who underwent IMRT using Linear Accelerator (LINAC) in Prof. dr. IGNG Ngoerah Hospital Denpasar between February to July 2023. Thyroid gland ultrasonography was then carried out for the patients at least six months after they completed radiation therapy. Patients were matched with healthy control 1:1. Patients with thyroid surgery, clinically or ultrasound-diagnosed thyroid abnormality, and incomplete medical record data were excluded. We performed an independent T-test and Mann-Whitney U statistical analysis with a confidence interval (CI) of 95%.
Results: The total research subjects were 56 people, consisting of 28 for each case and control group. The median age of subjects in the case group was 51 (33-64) years, while 36 (30-51) years were in the control group. There were also more males in the case group than in the control group (75% vs 42.9%). Independent t-tests were done on normally distributed data in echogenicity index and CPP while we used Mann-Whitney U tests for the remaining variables. Results showed that CPP and SWE from the case group are significantly higher than those of the control group.
Conclusion: Advanced ultrasonography techniques may detect several components of morphological changes in NPC patients undergoing IMRT. The technique may become the predictor for occult hypothyroidism to improve the quality of life of the patients.
Contribution of SIRS and sepsis on the outcomes of patients with burn injuries in Dr. Soetomo Teaching Hospital
Authors: Perkasa-Hendropriyono Alexander Akbar Wiratama , Saputro Iswinarno Doso , Dianti Yuanita Safitri 
Published: January 2025

Introduction: Sepsis can be defined as a systemic inflammatory response syndrome (SIRS) accompanied by a suspected or documented infection. One of the things that is often the concern of health workers in the management of burns is the presence of infections and permanent sepsis, as these are the leading causes of morbidity and mortality in patients with burns. This study aims to assess burn injuries patients with SIRS and SIRs accompanied by sepsis in one of the hospitals in Indonesia by identifying their mortality rates, length of hospitalization, potential risk factors in the patient's body, organ complications and the percentage of patients affected by SIRS accompanying sepsis to know the contribution of SIRs and SEPSIS to the outcome.
Methods: The research design used is retrospective, with data sources derived from secondary data. In its implementation, the study uses the total sampling method, where all data of burn patients treated at Burn Center Dr. Soetomo Teaching Hospital Surabaya from 2020-2023 are included as samples. Research data will be processed and analyzed using SPSS by Mann Whitney and the Chi-Square test. All findings from this analysis will be presented in table form for interpretation and analysis.
Results: The average rating in cases where SIRS occurred, the LOS was more prolonged than in cases where SIRS did not occur. SIRS has an effect on LOS. There was a significant difference in LOS between cases where sepsis and sepsis did not occur.
Conclusion: Our results show a significant relationship between SIRS and the occurrence of sepsis, TBSA, and the occurrence of SIRS and sepsis, SIRS and sepsis on outcome (LOS and mortality). Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus hemolytic are the germs most commonly found in culture cultures.
Association of Laminin subunit gamma-2 (LAMC2) gene expression with hepatic metastasis in colorectal cancer patient: An observational study
Authors: Hak Opi Zianul , Lukman Kiki , Rudiman Reno , Sulthana Bambang Am Am Setya , Sribudiani Yunia , Nugraha Prapanca 
Published: January 2025

Link of Video Abstract: https://youtu.be/niQyXOLjEnk

Background: Laminin subunit gamma-2 (LAMC2) is a novel biomarker in the tumorigenesis of colorectal cancer and has been associated with metastasis and prognosis of the disease. This study investigates the potential association between LAMC2 gene expression and hepatic metastasis, aiming to evaluate its potential as a reliable predictor of metastasis in colorectal cancer patients.
Methods: This is an observational analysis of data from patients with colorectal cancer, collected between January and April 2024 at the Centre for Genetic Studies, Faculty of Medicine, Universitas Padjadjaran, Bandung City, West Java, Indonesia. Tumor tissues were obtained via biopsy or surgical resection. The LAMC2 expression was measured through quantitative real-time PCR (qt-PCR). ANOVA and T-test analyses were done to assess the mean difference in LAMC2 expression levels in colorectal cancer patients with and without hepatic metastasis.
Results: The expression of LAMC2 did not show any significant differences between sex, anatomical pathology, tumor location, stage, and metastases. But there were significant differences between early onset and late onset (P = 0.029); patients with late onset showed a higher mean of LAMC2 expression.
Conclusion: Our investigation revealed no association between the expression levels of LAMC2 and the occurrence of hepatic metastasis in colorectal cancer. Nevertheless, it is anticipated that future studies employing larger sample sizes will provide more comprehensive insights. Moreover, the exploration of LAMC2 as a potential target for anticancer therapy warrants further consideration and development in subsequent research endeavors.
Effects of asymmetry in Kondo channels on thermoelectric efficiency
Authors: Nguyen T. K. T. , Cao T. B. , Chu T. A. , Nguyen T. L. H. , Nguyen H. Q. , Kiselev M. N. 
Published: January 2025

We revisit an asymmetric two-channel charge Kondo model, which has been studied in the [Phys. Rev. B 82 (2010) 113306]. A nano-device modelling two-channel Kondo physics is a large metallic quantum dot which is embedded into a two-dimensional electron gas (2DEG) and connected strongly to two electrodes through two almost transparent single-mode quantum point contacts. The 2DEG is in the integer quantum Hall regime [Z. Iftikhar et al., Nature (London) 526 (2015) 233]. The reflection amplitudes at the quantum point contacts are asymmetric. We find that the thermopower and the figure of merit are decreased but the Kondo resonance width and Lorenz number in the vicinity of the Coulomb peak are lifted due to the effects of asymmetry in Kondo channels. We propose the method to improve the thermoelectric efficiency of the device.
Biosample collection in a biobank to solve problems of personalized medicine
Authors: Kopylova O. V. , Ershova A. I. , Meshkov A. N. , Pokrovskaya M. S. , Efimova I. A. , Limonova A. S. , Blokhina A. V. , Serebryanskaya Z. Z. , Smetnev S. A. , Mikhailina V. I. , Myasnikov R. P. , Kiseleva A. V. , Garbuzova E. V. , Metelskaya V. A. , Borisova A. L. , Drapkina O. M. 
Published: January 2025

Aim. To present an approach to collection of biosamples of patients with rare and scientifically interesting clinical situations for solving the problems of personalized medicine, as well as to analyze related 8-year experience.Material and methods. The approach and a collection of biosamples of blood and its derivatives is developed at the National Medical Research Center for Therapy and Preventive Medicine within the project "Interesting Cases at the National Medical Research Center for Therapy and Preventive Medicine". The collection of biomaterial from project patients was carried out on a planned basis with the inpatient department, as well as upon referral from outpatient doctors. All included patients signed informed consent. Each biosample is accompanied by an extensive annotation, including socio-demographic, clinical, genetic and other types of data. The article presents the project results as of August 12, 2024.Results. An expert group developed 15 disease groups and related inclusion criteria. At the time of analysis, 4525 inpatients and outpatients were included in the project. Positive changes in the number of people included annually is noted. Genetic testing was performed on >2500 patients. The proposed approach allows solving a wide range of clinical and research problems in personalized medicine as follows: timely diagnosis or clarification; formation of patient cohorts to study the genetic aspects of diseases; identification of new genetic variants of hereditary diseases; development of genetic diagnostic panels; study of rare diseases; reduction of sample creation time in case of novel scientific ideas.Conclusion. The proposed approach to the collection and preservation of biosamples and related clinical, socio-demographic, genetic and other types of data in patients with rare clinical cases of scientific interest is important and effective for solving practical and research problems of personalized medicine. The algorithm is well developed, standardized and easily implemented within the clinics, regardless of their size. Preanalytical phase standardization creates the prerequisites for multicenter national and international cooperation.
Uji Kesesuaian Pengukuran Berat Badan antara Metode Lorenz dan Metode Modifikasi PAWPER-XL MAC dengan Tempat Tidur Bertimbangan Khusus
Authors: Pamugar Bramantyo , Suwarman Suwarman , Rismawan Budiana 
Published: January 2025

Berat badan aktual sangat penting di Intensive Care Unit (ICU). Baku standar penilaian berat badan aktual adalah timbangan khusus, namun timbangan ini tidak banyak tersedia di ICU. Alternatif lain untuk estimasi berat badan aktual dapat menggunakan metode antropometrik. Penelitian ini merupakan uji kesesuaian antara estimasi berat badan aktual menggunakan metode Lorenz dan modifikasi PAWPER-XL MAC dengan berat badan aktual menggunakan timbangan khusus baku standar. Penelitian ini adalah analitik observasional dengan potong lintang pada 83 pasien ICU rumah sakit Hasan Sadikin Bandung antara Agustus hingga November 2023. Uji kesesuaian menggunakan: uji t, P10, P20, mean percentage error (MPE), dan limit of agreement (LOA). Pasien metode Lorenz dan modifikasi PAWPER-XL MAC dengan rerata perawatan 2,00±1,704 dan rerata balans kumulatif 126,99±1483,62, didapatkan nilai p adalah 0,646 dan 0,717 secara berurutan, nilai P10 adalah 84,3% dan 71,1% secara berurutan, nilai P20 adalah 98,8% dan 95,2% secara berurutan, nilai MPE adalah 0,361 dan 0,463 secara berurutan, nilai LOA adalah -14,75 s/d 15,53 dan -18,12 s/d 19,04 secara berurutan. Semua berada dalam rentang yang direkomendasikan. Pengukuran estimasi berat badan aktual metode Lorenz dan modifikasi PAWPER-XL MAC sesuai dengan pengukuran berat badan aktual dengan tempat tidur bertimbangan khusus pada pasien-pasien ICU.
Formação inicial de professores: o fazer pedagógico e o diálogo com jovens do Ensino Médio
Authors: Melo Maria Alves de , Andrade Francisca Rejane Bezerra 
Published: January 2025

Este artigo objetiva contribuir com os estudos sobre a formação inicial de professores. Para tanto, buscou-se identificar a compreensão que os professores de Ensino Médio têm sobre a dialogicidade, bem como seus reflexos no fazer pedagógico em diálogo com os estudantes. Diante do exposto, reflete-se inicialmente sobre a formação inicial de professores, a partir da visão de autores como: Imbernón (2011), Garcia (1999), Brayner (2008), Buber (2012), Nóvoa (2019), Pimenta (2012), Veiga (2022), em diálogo com Paulo Freire (2019; 2021; 2021a; 2021b; 2021c). Na sequência, com base em pesquisa realizada com os professores que atuam nas escolas públicas estaduais de Ensino Médio de Fortaleza, e em conexão com o pensamento de Paulo Freire, buscou-se analisar a influência da dialogicidade, como categoria freireana, na materialidade das práticas pedagógicas dos professores das escolas de Ensino Médio pesquisadas, e apreender os sentidos que os professores atribuem aos processos de ensino-aprendizagem e suas vinculações com o entendimento do diálogo como ato educativo. Finalmente, os resultados da pesquisa evidenciaram o distanciamento dos cursos de formação inicial de professores de uma formação que contemple a dimensão pedagógica voltada para o diálogo. Portanto, foi perceptível a influência do diálogo no processo de ensino-aprendizagem, seja por meio de sua implementação por parte dos professores que adotam essa postura, seja ao contrário, pela ausência deste.