bluuebunny/crossref_metadata_2025_split huggingface dataset:
Levels of endoplasmic reticulum stress-related mRNA in peritoneal fluid of patients with endometriosis or gynaecological cancer
Authors: Yeo Seung Geun , Lee Sung Jong , Lee Ji Woo , Oh Sujung , Park Dong Choon 
Published: December 2021

Objective To compare the levels of endoplasmic reticulum (ER) stress-associated mRNAs and the clinical characteristics of patients with endometriosis or gynaecological cancer. Methods This prospective study obtained intraperitoneal fluid samples from female patients that underwent surgery. The levels of ER stress mRNAs in the peritoneal fluid, including C/EBP-homologous protein (CHOP), X-box binding protein 1 (sXBP1), activating transcription factor 6 (ATF6), immunoglobulin heavy chain-binding protein (BiP), inositol-requiring enzyme 1α (IRE1α) and protein kinase RNA-like endoplasmic reticulum kinase (PERK), were measured using real-time reverse transcription–polymerase chain reaction in patients with benign disease without endometriosis (control group), with endometriosis or with gynaecological cancer. Results This study enrolled 126 patients: 46 control patients; 47 with endometriosis; and 33 with cancer. The levels of CHOP and BiP mRNA were significantly higher in the control group compared with the cancer group. Levels of sXBP1 and ATF6 mRNA were significantly higher in the cancer group than in the control and endometriosis groups. In the endometriosis group, ATF6 mRNA level was inversely correlated with age and positively correlated with serum cancer antigen 125 levels; and ATF6 and PERK mRNA levels were inversely correlated with parity. Conclusion The levels of ER stress-related mRNAs were related to the pathogenesis of endometriosis and gynaecological cancers.
The Role of Indian Hedgehog Signaling in Tendon Response to Subacromial Impingement: Evaluation Using a Mouse Model
Authors: Liu Yulei , Deng Xiang-Hua , Zhang Xueying , Cong Ting , Chen Daoyun , Hall Arielle Jordan , Ying Liang , Rodeo Scott A. 
Published: December 2021

Background: The underlying cellular and molecular mechanisms involved in the development of tendinopathy due to subacromial supraspinatus tendon (SST) impingement and the response to subsequent removal of impingement remain unknown. Purpose: To investigate the involvement of Indian hedgehog (IHH) signaling in the development of SST tendinopathy and the subsequent healing process after the relief of subacromial impingement in a novel mouse shoulder impingement model. Study Design: Controlled laboratory study. Methods: A total of 48 male wild-type C57BL/6 mice were used in this study. Supraspinatus tendinopathy was induced by inserting a microsurgical clip into the subacromial space bilaterally. Eleven mice were sacrificed at 4 weeks after surgery to establish impingement baseline; 24 mice underwent clip removal at 4 weeks after surgery and then were euthanized at 2 or 4 weeks after clip removal. Thirteen mice without surgical intervention were utilized as the control group. All SSTs were evaluated with biomechanical testing; quantitative histomorphometry after staining with hematoxylin and eosin, Alcian blue, and picrosirius red; and immunohistochemical staining (factor VIII, IHH, Patched1 [PTCH1], and glioma-associated oncogene homolog 1 [GLI1]). Results: The mean failure force and stiffness in the 4-week impingement group decreased significantly compared with the control group ( P < .001) and gradually increased at 2 and 4 weeks after clip removal. Histological analysis demonstrated increased cellularity and disorganized collagen fibers in the SST, with higher modified Bonar scores at 4 weeks, followed by gradual improvement after clip removal. The IHH-positive area and PTCH1- and GLI1-positive cell percentages significantly increased after 4 weeks of clip impingement (20.64% vs 2.06%, P < .001; 53.9% vs 28.03%, P = .016; and 30% vs 12.19%, P = .036, respectively) and continuously increased after clip removal. Conclusion: The authors’ findings suggest that the hedgehog signaling pathway and its downstream signaling mediator and target GLI1 may play a role in the development and healing process of rotator cuff tendinopathy due to extrinsic rotator cuff impingement. Clinical Relevance: This study suggests the potential for the hedgehog pathway, together with its downstream targets, as candidates for further study as potential therapeutic targets in the treatment of supraspinatus tendinopathy.
Health Care Professionals’ Experiences of Facilitating Patient Activation and Empowerment in Chronic Illness using a Person-Centered and Strengths-Based Self-Management Program
Authors: Heggdal Kristin , Stepanian Natalie , Oftedal Bjørg Frøysland , Mendelsohn Joshua B. , Larsen Marie Hamilton 
Published: December 2021

Objective Patients with chronic illness who are empowered and activated are more likely to engage in self-management in order to stabilise their condition and enhance their quality of life. This study aimed to explore Health Care Professional's (HCP) assessment of a person-centered intervention called ‘The Bodyknowledging Program’ (BKP) for the facilitation of empowerment and patient activation in the context of chronic illness. Methods This study employed a qualitative process evaluation after programme completion. Data was collected through focus-groups and individual interviews with HCPs and content analysis was used in the analysis. Results Four themes were identified: 1) Shifts towards the patient-perspective, 2) The value of a patient-centered conceptual framework, 3) Patient activation through dialogue based support and 4) Challenging competencies. Discussion: This study introduces ‘The Bodyknowledging Program’ as a useful tool to uncover patients’ needs and to activate and empower them to take more responsibility for their health through self-care management. The usability of the new intervention depends on HCP's ability to develop their counselling skills and changing their approach towards utilising patients’ individual resources in the promotion of their health.
Clinical features of severe fever with thrombocytopenia syndrome and analysis of risk factors for mortality
Authors: He Feng , Zheng Xinxin , Zhang Zhaoru 
Published: December 2021

Abstract
Background
To understand the clinical characteristics of and explore the risk factors for mortality in patients with severe fever with thrombocytopenia syndrome (SFTS).

Methods
Data from SFTS patients diagnosed by laboratory examination at Chaohu Hospital affiliated with Anhui Medical University from June 2017 to January 2021 were retrospectively analysed. According to the clinical results, all confirmed patients were divided into the surviving group (80 patients) and non-surviving group (20 patients). The two groups were compared in terms of general characteristics, clinical symptoms and signs, laboratory indicators and other aspects. The independent risk factors for mortality in SFTS patients were analysed by multivariate binary logistic regression.

Results
Univariate analysis showed a significant difference in age and the incidence of consciousness disturbance, respiratory failure, haemorrhagic manifestations, renal dysfunction, shock, aspartate aminotransferase (AST) ≥400 U/L, creatine kinase (CK)≥1000 U/L, creatine kinase isoenzymes (CK-MB) ≥100 U/L, lactate dehydrogenase (LDH) ≥1000 U/L, serum creatinine ≥100 mmol/L, blood urea nitrogen ≥7.5 mmol/L and C-reactive protein ≥8 mg/L between the two groups (P < 0.05).

Conclusions
Consciousness disorder, haemorrhagic manifestations, renal dysfunction, AST ≥ 400 U/L, and LDH ≥ 1000 U/L are independent risk factors for mortality in SFTS patients and merit close attention in clinical treatment to avoid fatal consequences.
The cost of care for children hospitalised with Invasive Group A Streptococcal Disease in Australia
Authors: Brusco Natasha K. , Oliver Jane , McMinn Alissa , Steer Andrew , Crawford Nigel 
Published: December 2021

Abstract
Background
Invasive Group A Streptococcal (iGAS) disease exerts an important burden among Australian children. No Australian hospitalisation cost estimates for treating children with iGAS disease exist, so the financial impact of this condition is unknown.

Aim
To determine the minimum annual healthcare cost for children (< 18 years) hospitalised with iGAS disease in Australia from a healthcare sector perspective.

Methods
A cost analysis including children with laboratory-confirmed iGAS disease hospitalised at the Royal Children’s Hospital (Victoria, Australia; July 2016 to June 2019) was performed. Results were extrapolated against the national minimum iGAS disease incidence. This analysis included healthcare cost from the 7 days prior to the index admission via General Practitioner (GP) and Emergency Department (ED) consultations; the index admission itself; and the 6 months post index admission via rehabilitation admissions, acute re-admissions and outpatient consultations. Additional extrapolations of national cost data by age group, Aboriginal and Torres Strait Islander ethnicity and jurisdiction were performed.

Results
Of the 65 included children, 35% (n = 23) were female, 5% (n = 3) were Aboriginal and Torres Strait Islander, and the average age was 4.4 years (SD 4.6; 65% aged 0–4). The iGAS disease related healthcare cost per child was $67,799 (SD $92,410). These costs were distributed across the 7 days prior to the index admission via GP and ED consultations (0.2 and 1.1% of total costs, respectively), the index admission itself (88.7% of the total costs); and the 6 months post index admission via rehabilitation admissions, acute re-admissions and outpatient consultations (5.3, 4.5 and 0.1% of total costs, respectively). Based on a national minimum paediatric incidence estimation of 1.63 per 100,000 children aged < 18 (95%CI: 1.11–2.32), the total annual healthcare cost for children with iGAS in 2019 was $6,200,862. The financial burden reflects the overrepresentation of Aboriginal and Torres Strait Islander people in the occurrence of iGAS disease. Costs were concentrated among children aged 0–4 years (62%).

Conclusion
As these cost estimations were based on a minimum incidence, true costs may be higher. Strengthening of surveillance and control of iGAS disease, including a mandate for national notification of iGAS disease, is warranted.

Trial registration
The current study is a part of ongoing iGAS surveillance work across seven paediatric health services in Australia. As this is not a clinical trial, it has not undergone trial registration.
Atypical drainage of a persistent left vena cava superior into the left atrial appendage detected by multidimensional imaging: a case report and review of the literature
Authors: Lengning Sophie , Aschenbach René , Schulze P. Christian , Franz Marcus 
Published: December 2021

Abstract
Background
While it is the most common thoracic venous anomaly, a persistent left vena cava superior may present in atypical variations, which are important to consider during clinical management.

Case presentation
Here we report a 35-year-old Caucasian female patient with drainage into the left atrial appendage who presented with shortness of breath accompanied by mild hypoxemia. Venous contrast filling in the context of pulmonary scintigraphy suspected an additional superior caval vein connected to the left atrial appendage. Diagnosis was confirmed by transesophageal echocardiography. Cardiac catheterization revealed a minor right-to-left shunt. The symptoms could be allocated to a bronchial asthma and treated according to guidelines. Cerebral lesions detected in the patient were due to a coincident multiple sclerosis rather than cerebral embolisms. Thus, the venous anomaly was classified as an incidental finding currently requiring no treatment.

Conclusions
To the best of our knowledge, this is the first report of a persistent left vena cava superior draining into the left atrial appendage.
The 2020 Ming K. Jeang awards for excellence in Cell & Bioscience
Authors: Lau Yun-Fai Chris 
Published: December 2021

AbstractThree articles published by the research groups led by Yun-Bo Shi of the National Institute of Child Health and Human Development, National Institutes of Health, USA; Aria Baniahmad of the Institute of Human Genetics, Jena University Hospital, Germany; and Kuanyu Li of the Nanjing University Medical School, China, have been selected as the recipients of the 2020 Ming K. Jeang Award for Excellence in Cell and Bioscience.
Significance of nutrition in hemodialysis patients with peripheral arterial disease evaluated by skin perfusion pressure
Authors: Watanabe Maho , Fuji Asami , Tokushima Sayuri , Uemoto Keiko , Ueno Masayo , Shimomura Yuko , Ito Kenji , Yasuno Tetsuhiko , Masutani Kosuke , Saito Takao 
Published: December 2021

Abstract
Background
Peripheral artery disease (PAD) is a serious complication in hemodialysis (HD) patients. Low skin perfusion pressure (SPP) is a useful marker for detecting PAD. Malnutrition is an important cause of intractable complications. We examined the relationship between low SPP and various indicators of nutritional status.

Methods
A total of 120 patients on maintenance HD were enrolled for SPP measurement. SPP was measured at the soles of both feet during HD, and patients were divided into low SPP (L-SPP) and normal SPP (N-SPP) groups by 50 mmHg. The following values were determined by averaging four blood samples taken before SPP measurements every 3 months for one year: hemoglobin, total protein, albumin (Alb), total cholesterol, urea nitrogen, creatinine (Cr), potassium, calcium, phosphate, intact parathyroid hormone, iron (Fe), transferrin saturation (T-SAT), and C-reactive protein (CRP). We calculated the percent Cr production rate, dialysis index (Kt/V), normalized protein catabolic rate (nPCR), geriatric nutritional risk index (GNRI), and estimated salt intake using the required formulas. In addition, the age, body mass index, and presence of diabetes mellitus (DM) were compared between both groups along with all other measurements. Data were expressed as the mean ± standard deviation or median with interquartile range as appropriate. Differences in continuous variables between the two groups were analyzed by Student’s t-test or Wilcoxon’s rank-sum test, as appropriate. Multivariate logistic analysis and receiver operating curve (ROC) analysis were performed for significant variables. The results were expressed as odds ratios with respective 95% confidence intervals (CIs).

Results
The enrolled patients were 82 men and 38 women, with a mean age of 66.9 ± 13.3 years and HD duration of 4.76 (2.13–12.28) years (median interquartile range). Twenty patients belonged to the L-SPP group, suggesting PAD. Comparison between the L-SPP and N-SPP groups showed significant differences in age, Cr, Fe, T-SAT, CRP, nPCR, GNRI, DM, and estimated salt intake. When the GNRI, estimated salt intake, CRP, and DM were applied as independent variables for multiple logistic regression analysis, the GNRI (odds ratio: 0.857, 95% CI 0.781–0.941, p = 0.001), CRP (2.406, 1.051–3.980, p = 0.035), and DM (9.194, 2.497–33.853, p = 0.001) were found to be significant for L-SPP, and a cutoff level of 92.1 (sensitivity 80%, specificity 72%, AUC: 0.742, 95% CI 0.626–0.858, p = 0.001) in the GNRI obtained by ROC was consistent with the risk index in the elderly presented previously.

Conclusions
SPP measurement is an essential tool for detecting high-risk PAD in maintenance HD, which is affected by malnutrition, DM, and inflammation. The GNRI is important for the determination of malnutrition.
Optimal reactive power dispatch using a novel optimization algorithm
Authors: Roy Ranjit , Das Tanmay , Mandal Kamal Krishna 
Published: December 2021

AbstractThe problem of optimal reactive power dispatch (ORPD) is one of the most popular and widely discussed problem in power system engineering all over the world. Optimal reactive power dispatch is one of the sub-problems of the optimal power flow which is complex and nonlinear problem, which can be formulated as both single- and multi-objective. In this paper, the problem has been formulated as a single-objective problem to minimize the active power losses in the transmission lines. A recently proposed powerful and reliable meta-heuristic algorithm known as the JAYA algorithm has been applied to solve the ORPD problem. The algorithm has been applied on the standard IEEE 14, 30, 57 and 118 bus systems. The simulation results using the proposed algorithm when compared with the results from other algorithms and few others reported in the literature prove that the JAYA algorithm is the most superior among all.
K-way Balanced Graph Partitioning for Parallel Computing
Authors: Patil Siddheshwar Vilas , Kulkarni Dinesh B. 
Published: December 2021

In modern computing, high-performance computing (HPC) and parallel computing require most of the decision-making in terms of distributing the payloads (input) uniformly across the available set of resources, majorly processors; the former deals with the hardware and its better utilization. In parallel computing, a larger, complex problem is broken down into multiple smaller calculations and executed simultaneously on several processors. The efficient use of resources (processors) plays a vital role in achieving the maximum throughput which necessitates uniform load distribution across available processors, i.e. load balancing. The load balancing in parallel computing is modeled as a graph partitioning problem. In the graph partitioning problem, the weighted nodes represent the computing cost at each node, and the weighted edges represent the communication cost between the connected nodes. The goal is to partition the graph G into k partitions such that: I) the sum of weights on the nodes is approximately equal for each partition, and, II) the sum of weights on the edges across different partitions is minimum. In this paper, a novel node-weighted and edge-weighted k-way balanced graph partitioning (NWEWBGP) algorithm of O(n x n) is proposed. The algorithm works for all relevant values of k, meets or improves on earlier algorithms in terms of balanced partitioning and lowest edge-cut. For evaluation and validation, the outcome is compared with the ground truth benchmarks.
Opinião Pública e Política Externa: Do Consenso de Almond-Lippmann às Redes Sociais l Public Opinion and Foreign Policy: From The Almond-Lippmann Consensus to Social Media
Authors: Ferreira Alves Gustavo Jordan 
Published: December 2021

Neste artigo apresento uma linha cronológica que debate a relação entre opinião pública e temas de política externa ao longo das décadas. Demonstro as teorizações que trabalham com o consenso de Almond-Lippmann até as mais recentes teorias sobre opinião pública na era das redes sociais. Utilizando metodologias quantitativas e qualitativas, principalmente através de uma revisão da literatura já consolidada, apresento a conclusão de que em tal cronologia prevalece a perspectiva de que os eleitores de democracias como os Estados Unidos ou Brasil são majoritariamente desatentos a temas internacionais, mas não necessariamente irracionais em tais assuntos. Nesse sentido, no atual quadro de polarização política, em que mandatários como Donald Trump (2017-2021) e Jair Bolsonaro (2019-) utilizam massivamente redes sociais, surgem novos questionamentos nesse debate, desafiando o papel da mídia tradicional, especialmente depois da popularização dessas novas ferramentas de comunicação.Palavras-chave: Opinião Pública; Política Externa; Mídia.ABSTRACTIn this paper, it is presented a chronology that debates the relation between public opinion and foreign affairs subjects throughout the decades. I demonstrate theories starting from the Almond-Lippmann consensus until more recent ones discussing public opinion on the social media age. By using quantitative and qualitative methodologies, specially through reviewing the literature about public opinion and foreign policy that along the decades became reference in this realm, it is possible conclude that prevails the perspective that voters from democracies such as the United States and Brazil are mostly inattentive in international matters, however, they are not necessarily irrational. In this sense, the recent process of polarization in politics, where leaders such as Donald Trump (2017-2021) and Jair Bolsonaro (2019-) are constantly using social media, brings new questionings to this debate, challenging the role of the traditional media, especially after the popularization of those new communication tools.Keywords: Public Opinion; Foreign Policy; Media. Recebido em: 27/03/2021 | Aceito em: 17/08/2021.
E as mulheres? Uma Perspectiva Feminista Sobre a Resolução de Conflitos Armados l What About Women? A Feminist Perspective on Armed Conflict Resolution
Authors: Alves de Oliveira Mariana Germana Miquelino 
Published: December 2021

Neste artigo, buscamos entender as implicações das relações de gênero para a resolução de conflitos armados e as possíveis contribuições resultantes da inclusão de mulheres nos processos de paz. À luz das teorias feministas das Relações Internacionais, propomos a hipótese de que não se pode compreender amplamente as dinâmicas de um conflito armado sem considerar a influência das relações de gênero para a sua eclosão e continuidade e, por conseguinte, não se pode implementar medidas de resolução que sejam plenamente eficientes. Mais do que isso, sugerimos que as mulheres sejam parte ativa dos esforços de construção da paz para que esse processo se torne mais representativo e possa responder também às fontes de insegurança feminina.Palavras-chave: Resolução de conflitos; Construção da paz; Mulheres.ABSTRACTIn this article, we seek to understand the implications of gender relations for the resolution of armed conflicts and the possible contributions resulting from the inclusion of women in peace processes. In the light of feminist theories of International Relations, we propose the hypothesis that one cannot fully understand the dynamics of armed conflict without considering the influence of gender relations for its outbreak and continuity and, therefore, resolution measures that are fully efficient cannot be implemented. Furthermore, we suggest that for the peace process to become more representative and to respond to sources of female insecurity as well.Keywords: Conflict resolution; Peace building; Women. Recebido em: 10/04/2021 | Aceito em: 27/07/2021.
ANÁLISIS DEL MARCO JURÍDICO PENAL DE JUSTICIA RESTAURATIVA EN MÉXICO Y PANAMÁ: UN ENFOQUE INTEGRAL SOBRE SU IMPERIOSA ARMONIZACIÓN
Authors: Silva Yulisán Fernández , Montes Jazmín Flores 
Published: December 2021

El artículo analiza la construcción normativa, en el ámbito penal, de la JR en México y Panamá con el propósito de detectar áreas de perfeccionamiento proclives a la articulación de un modelo procesal integral y armónico en las normativas de estas naciones. Se toma como referencia las normativas procesales para adolescentes, las leyes especiales de Métodos de Solución de Conflictos, y los procedimientos referentes a la fase de ejecución penal.