bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autoimmune liver disease-associated serologic profiling in Chinese patients with acute hepatitis E virus infection
Authors: Gui Honglian , Wang Weijing , Li Qing , Li Ziqiang , Lu Jie , Xie Qing 
Published: January 2021

AbstractThe association between hepatitis E virus (HEV) and autoimmune liver diseases has been well-researched; however, the focus has been on autoimmune hepatitis (AIH) and not primary biliary cholangitis (PBC). Therefore, we aimed to investigate the prevalence and evolution of AIH- and PBC-related autoantibodies in Chinese patients with HEV infection. In this retrospective study, 164 patients with acute HEV were included, specifically those whose liver autoantibody results were available and who had no pre-existing liver disease at the time of HEV diagnosis. Positive liver autoimmune serology was present in 69 (42.1%) patients and 21 (12.8%) had at least two autoantibodies at diagnosis. Greater age and alkaline phosphatase levels were independent risk factors for autoantibody positivity. Follow-up serologic tests, which were available for 27 of the 69 autoantibody-positive patients, showed that although antinuclear antibodies disappeared in 11/20 (55.0%) and antimitochondrial antibodies disappeared in 4/5 (80%) patients, 16 still remained positive for autoantibodies and two of them even developed new PBC-related antibodies, as described below. One patient developed a rim-like ANA pattern, accompanied by an enhancement of anti-gp210 positivity; and the other was diagnosed as PBC, based on chronic elevation of cholestatic enzymes and presentation with de novo AMA-M2, 18 months after HEV clearance. In conclusion, AIH- and PBC-related autoantibodies are frequently present during acute HEV infection, indicating that HEV should be excluded before diagnosing AIH and/or PBC. Importantly, some cases maintained or developed autoantibodies after viral clearance, and one patient subsequently developed PBC, highlighting that these individuals warrant long-term follow-up.
Geographical Variation in Local Gender Contracts in Sweden
Authors: Haandrikman Karen , Webster Natasha A. , Duvander Ann-Zofie 
Published: January 2021

AbstractDespite Sweden’s national gender-neutral family and social policies, local differences in gender contracts exist and have been related to differences in the structure of the labour market and cultural traditions. Existing studies are outdated and used relatively large administratively defined areas, which may lead to several measurement and interpretation errors. This paper examines geographical variation in gender contracts in present-day Sweden using individualized neighbourhoods on different scales. Gender contracts are operationalized using six indicators on the level of family, politics and labour. We identify five types of local gender contracts: the metropolitan gender contract, the progressive gender contract, the suburban gender contract, the commuter gender contract and the traditional gender contract. The most gender equal patterns are found in metropolitan and other urban areas, with high shares of fathers taking parental leave and the highest shares of women with high education and gainful employment, and low shares of young mothers. The analyses give evidence of considerable local variation instead of a dominant gender contract in each region. The findings may stimulate further research and local policies on gender inequality.
Mineralogical, petrological and planetological heritage. The (Italian) story so far
Authors: Pratesi Giovanni , Franza Annarita 
Published: January 2021

AbstractThe goal of this work is to further increase the use, by all the stakeholders, of well-established and official cataloguing methods for the preservation, valorisation and study of naturalistic heritage. The work describes the standards of the Central Institute for Cataloguing and Documentation (ICCD) for cataloguing the Italian mineralogical, petrological and planetological heritage to the community of scientists, curators and museum practitioners. This work then provides an overview of the geoscientific heritage already catalogued through these standards and freely available for study and research purposes on the SIGECweb online database. Finally, the importance of a standardized cataloguing—in the comprehension of the historical, cultural and ethical aspects relative to the conservation and valorisation of the geoscientific heritage—will also be highlighted.
Kinetics of fluoride adsorption onto native and Mg(OH)2-amended limestone
Authors: AL-Darwish Noura , Abu-Sharar T. M. 
Published: January 2021

AbstractThe adsorption kinetics of fluoride onto limestone (LS) and Mg(OH)2-amended LS were investigated using batch adsorption technique. Data were best fitted to second-order and Elovich models. The Mg(OH)2-ameded LS showed substantial increases in F− adsorption relative to native LS. Similarity of ionic radii and charge of both F− and OH− were hypothesized to be the major cause of such increases. The OH− functional group of the surface Mg(OH)2 could be exchanged by aqueous F− through surface complexation (ligand exchange). No background effect of naturally occurring anions in F−-rich groundwater on adsorption capacity of Mg(OH)2-amended LS. The results reveal that the Mg(OH)2-amended LS can be environmentally safe and economical for F− removal.
Synthesis of amino acid functionalized Fe3O4 nanoparticles for adsorptive removal of Rhodamine B
Authors: Belachew Neway , Tadesse Aschalew , Kahsay Mebrahtu Hagos , Meshesha Desta Shumuye , Basavaiah Keloth 
Published: January 2021

AbstractL-Aspartic acid (L-Asp) functionalized magnetite nanoparticles (Fe3O4 NPs) were synthesized through a facile co-precipitation method using L-Asp as a capping agent. UV–Vis, FTIR, XRD, SEM, EDS, TEM, and VSM techniques were used to investigate the formation, morphology, elemental composition, and magnetic properties of the synthesized Fe3O4 NPs. Highly crystalline and spherical shaped pure phase Fe3O4 NPs were successfully synthesized using amino acid as a capping agent. The magnetic measurement analysis confirms the superparamagnetic nature of the synthesized L-Asp capped Fe3O4 NPs. The adsorption efficiency of L-Asp capped Fe3O4 NPs was assessed by the removal of Rhodamine B (RhB). The optimum removal efficiency was found to be 7.7 mg g−1 using 1 mg mL−1 adsorbent, and 30 mg L−1 RhB at pH 7 and 25 °C. The regression (R2adj) and standard deviation (SD) analysis were used to validate both kinetic and isotherm models. Avrami fractional-order and Liu models were selected as the best kinetic and isotherms, respectively. The maximum adsorption capacity (Qo) of L-Asp Fe3O4 NPs toward RhB Liu’s model was found to be 10.44 mg g−1.
Assessing visuo-constructive functions in patients with subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease with the Vienna Visuo-Constructional Test 3.0 (VVT 3.0)
Authors: Valencia Noel , Lehrner Johann 
Published: January 2021

Summary
Background
Visuo-Constructive functions have considerable potential for the early diagnosis and monitoring of disease progression in Alzheimer’s disease.

Objectives
Using the Vienna Visuo-Constructional Test 3.0 (VVT 3.0), we measured visuo-constructive functions in subjective cognitive decline (SCD), mild cognitive impairment (MCI), Alzheimer’s disease (AD), and healthy controls to determine whether VVT performance can be used to distinguish these groups.

Materials and methods
Data of 671 participants was analyzed comparing scores across diagnostic groups and exploring associations with relevant clinical variables. Predictive validity was assessed using Receiver Operator Characteristic curves and multinomial logistic regression analysis.

Results
We found significant differences between AD and the other groups. Identification of cases suffering from visuo-constructive impairment was possible using VVT scores, but these did not permit classification into diagnostic subgroups.

Conclusions
In summary, VVT scores are useful indicators for visuo-constructive impairment but face challenges when attempting to discriminate between several diagnostic groups.
Spatial characterization of propagation channels for terahertz band
Authors: Aghoutane Bilal , El Ghzaoui Mohammed , El Faylali Hanan 
Published: January 2021

AbstractThe aim of this work consists in characterizing the Terahertz (THz) propagation channel in an indoor environment, in order to propose a channel model for THz bands. We first described a propagation loss model by taking into account the attenuation of the channel as a function of distance and frequency. The impulse response of the channel is then described by a set of rays, characterized by their amplitude, their delay and their phase. Apart from the frequency selective nature, path loss in THz band is also an others issue associated with THz communication systems. This work based on the conventional Saleh-Valenzuela (SV) model which is intended for indoor scenarios. In this paper, we have introduced random variables as Line of sight (LOS) component, and then merging it with the SV channel model to adopt it to the THz context. From simulation, we noted an important effect when the distance between the transmitter and the receiver change. This effect produces variations in frequency loss. The simulations carried out from this model show that to enhance the performance of THz system it is recommended to transmit information over transmission windows instead over the whole band.
Vascular Contributions to Neurodegeneration: Protocol of the COMPASS-ND Study
Authors: Smith Eric E. , Duchesne Simon , Gao Fuqiang , Saad Feryal , Whitehead Victor , McCreary Cheryl R. , Frayne Richard , Gauthier Serge , Camicioli Richard , Borrie Michael , Black Sandra E. 
Published: January 2021

ABSTRACT:Objective:To describe the neuroimaging and other methods for assessing vascular contributions to neurodegeneration in the Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) study, a Canadian multi-center, prospective longitudinal cohort study, including reliability and feasibility in the first 200 participants.Methods:COMPASS-ND includes persons with Alzheimer’s disease (AD; n = 150), Parkinson’s disease (PD) and Lewy body dementias (LBDs) (200), mixed dementia (200), mild cognitive impairment (MCI; 400), subcortical ischemic vascular MCI (V-MCI; 200), subjective cognitive impairment (SCI; 300), and cognitively intact elderly controls (660). Magnetic resonance imaging (MRI) was acquired according to the validated Canadian Dementia Imaging Protocol and visually reviewed by either of two experienced readers blinded to clinical characteristics. Other relevant assessments include history of vascular disease and risk factors, blood pressure, height and weight, cholesterol, glucose, and hemoglobin A1c.Results:Analyzable data were obtained in 197/200 of whom 18 of whom were clinically diagnosed with V-MCI or mixed dementia. The overall prevalence of infarcts was 24.9%, microbleeds was 24.6%, and high white matter hyperintensity (WMH) was 31.0%. MRI evidence of a potential vascular contribution to neurodegeneration was seen in 12.9%–40.0% of participants clinically diagnosed with another condition such as AD. Inter-rater reliability was good to excellent.Conclusion:COMPASS-ND will be a useful platform to study vascular brain injury and its association with risk factors, biomarkers, and cognitive and functional decline across multiple age-related neurodegenerative diseases. Initial findings show that MRI-defined vascular brain injury is common in all cognitive syndromes and is under-recognized clinically.
A structure theorem for stochastic processes indexed by the discrete hypercube
Authors: Dodos Pandelis , Tyros Konstantinos 
Published: January 2021

Abstract
Let A be a finite set with

, let n be a positive integer, and let

$A^n$

denote the discrete

$n\text {-dimensional}$

hypercube (that is,

$A^n$

is the Cartesian product of n many copies of A). Given a family

$\langle D_t:t\in A^n\rangle $

of measurable events in a probability space (a stochastic process), what structural information can be obtained assuming that the events

$\langle D_t:t\in A^n\rangle $

are not behaving as if they were independent? We obtain an answer to this problem (in a strong quantitative sense) subject to a mild ‘stationarity’ condition. Our result has a number of combinatorial consequences, including a new (and the most informative so far) proof of the density Hales-Jewett theorem.
Do campaign contributions buy favorable policies? Evidence from the insurance industry
Authors: Fouirnaies Alexander , Fowler Anthony 
Published: January 2021

AbstractTo learn about the effects of corporate campaign contributions, we study the potential influence of the insurance industry in US state politics. The insurance industry is one of the biggest players in state politics, and we have collected new data on objective measures of the industry's performance in each state over time. We exploit within-state changes in campaign finance regulations which can significantly restrict the ability of corporate contributors to give money and potentially influence elected officials. Across a range of outcomes and campaign finance reforms, we find little evidence that the ability to make corporate campaign contributions benefits the insurance industry in a state. Some results suggest that the ability to make campaign contributions may benefit the insurance industry in states with elected insurance commissioners, but overall, campaign contributions appear to have a little distortionary effect even in a setting where we would most expect to find it.
THE ABSOLUTE CHRONOLOGY OF COLLECTIVE BURIALS FROM THE 2ND MILLENNIUM BC IN EAST CENTRAL EUROPE
Authors: Makarowicz Przemysław , Goslar Tomasz , Górski Jacek , Taras Halina , Szczepanek Anita , Pospieszny Łukasz , Jagodinska Marina O , Ilchyshyn Vasyl , Włodarczak Piotr , Juras Anna , Chyleński Maciej , Muzolf Przemysław , Lasota-Kuś Anna , Wójcik Irena , Matoga Andrzej , Nowak Marek , Przybyła Marcin M , Marcinkowska-Swojak Małgorzata , Figlerowicz Marek , Grygiel Ryszard , Czebreszuk Janusz , Kochkin Igor T 
Published: January 2021

ABSTRACTThis article discusses the absolute chronology of collective burials of the Trzciniec Cultural Circle communities of the Middle Bronze Age in East Central Europe. Based on Bayesian modeling of 91 accelerator mass spectrometry radiocarbon (AMS 14C) dates from 18 cemeteries, the practice of collective burying of individuals was linked to a period of 400–640 (95.4%) years, between 1830–1690 (95.4%) and 1320–1160 (95.4%) BC. Collective burials in mounds with both cremation and inhumation rites were found earliest in the upland zone regardless of grave structure type (mounded or flat). Bayesian modeling of 14C determinations suggests that this practice was being transmitted generally from the southeast to the northwest direction. Bayesian modeling of the dates from the largest cemetery in Żerniki Górne, Lesser Poland Upland, confirmed the duration of use of the necropolis as ca. 140–310 (95.4%) years. Further results show the partial contemporaneity of burials and allow formulation of a spatial and temporal development model of the necropolis. Based on the investigation, some graves were used over just a couple of years and others over nearly 200, with up to 30 individuals found in a single grave.
SURFACE OCEAN RADIOCARBON FROM A PORITES CORAL RECORD IN THE GREAT BARRIER REEF: 1945–2017
Authors: Wu Yang , Fallon Stewart J , Cantin Neal E , Lough Janice M 
Published: January 2021

ABSTRACTWe present a high-resolution seawater radiocarbon (Δ14C) record from a Porites coral collected from Masthead Island in the southern Great Barrier Reef (GBR) covering the years 1945–2017. The Δ14C values from 1945–1953 (pre-bomb era) averaged –49‰. As a result of bomb-produced 14C in the atmosphere, Δ14C values started to rise rapidly from 1959, levelled off at ∼131‰ in the late 1970s and gradually decreased to ∼40.3‰ by 2017 due to the decrease in the air-sea 14C gradient and the overturning of the 14C ocean reservoir (i.e., surface ocean to subsurface ocean; atmosphere to surface ocean). The Masthead Island record is in agreement with previous 14C coral records from the southern GBR. A comparison between surface ocean and atmospheric Δ14C suggests that, since 2010, the main reservoir of bomb-derived 14C has shifted from the atmosphere to the surface ocean, potentially resulting in reversed 14C flux in regions where the CO2 gradient is favorable. The high-resolution Masthead coral Δ14C sheds light on long-term variability in air-sea exchange and GBR regional ocean dynamics associated with climate change and in conjunction with the previous records provides a robust seawater 14C reference series to date other carbonate samples.
TWO SUPERCONGRUENCES RELATED TO MULTIPLE HARMONIC SUMS
Authors: TAURASO ROBERTO 
Published: January 2021

AbstractLet p be a prime and let x be a p-adic integer. We prove two supercongruences for truncated series of the form
$$\begin{align*}\sum_{k=1}^{p-1} \frac{(x)_k}{(1)_k}\cdot \frac{1}{k}\sum_{1\le j_1\le\cdots\le j_r\le k}\frac{1}{j_1^{}\cdots j_r^{}}\quad\mbox{and}\quad \sum_{k=1}^{p-1} \frac{(x)_k(1-x)_k}{(1)_k^2}\cdot \frac{1}{k}\sum_{1\le j_1\le\cdots\le j_r\le k}\frac{1}{j_1^{2}\cdots j_r^{2}}\end{align*}$$
which generalise previous results. We also establish q-analogues of two binomial identities.
Phospholipase C signal mediated the glucose-induced changes of glucose absorption and lipid accumulation in the intestinal epithelial cells of yellow catfishPelteobagrus fulvidraco
Authors: Zhao Tao , Yang Shui-Bo , Xu Yi-Chuang , Chen Guang-Hui , Xu Yi-Huan , Luo Zhi 
Published: January 2021

AbstractIn present study, we explored the effects and the underlying mechanisms of phospholipase C (PLC) mediating glucose-induced changes in intestinal glucose transport and lipid metabolism by using U-73122 (a PLC inhibitor). We found that glucose incubation activated the PLC signal and U-73122 pre-incubation alleviated the glucose-induced increase inplcb2,plce1andplcg1mRNA expression. Meanwhile, U-73122 pre-treatment blunted the glucose-induced increase in sodium/glucose co-transporters 1/2 mRNA and protein expressions. U-73122 pre-treatment alleviated the glucose-induced increase in TAG content, BODIPY 493/503 fluorescence intensity, lipogenic enzymes (glucose 6-phospate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), malic enzyme and fatty acid synthase (FAS)) activity and the mRNA expressions of lipogenic genes and related transcription factors (6pgd, g6pd, fas, acca, srebp1and carbohydrate response element-binding protein (chrebp)) in intestinal epithelial cells of yellow catfish. Further research found that U-73122 pre-incubation mitigated the glucose-induced increase in the ChREBP protein expression and the acetylation level of ChREBP in HEK293T cells. Taken together, these data demonstrated that the PLC played a major role in the glucose-induced changes of glucose transport and lipid metabolism and provide a new perspective for revealing the molecular mechanism of glucose-induced changes of intestinal glucose absorption, lipid deposition and metabolism.
New insights into the early evolution of horizontal spiral trace fossils and the age of the Brioverian series (Ediacaran–Cambrian) in Brittany, NW France
Authors: Gougeon Romain , Néraudeau Didier , Loi Alfredo , Poujol Marc 
Published: January 2021

AbstractIn northwestern France, the Brioverian series is a thick siliciclastic succession deposited during the Cadomian cycle (c. 750–540 Ma). In the uppermost Brioverian beds, previous studies unravelled an assemblage dominated by simple horizontal trace fossils associated with microbially stabilized surfaces. Here, we report Spirodesmos trace fossils – one-way, irregular and regular horizontal spirals – from Crozon (Finistère, Brittany), Montfort-sur-Meu and St-Gonlay (Ille-et-Vilaine, Brittany). After reviewing the literature on horizontal spiral trace fossils, an Ediacaran–Fortunian Spirodesmos pool is identified from marginal-marine to shelf settings, while an Ordovician–Recent trend formed in the deep-marine realm. These results suggest that an onshore–offshore migration in Spirodesmos took place during Ediacaran–Fortunian to Ordovician time, similar to what happened in graphoglyptids. In addition, the age of the uppermost Brioverian beds (Ediacaran or early Cambrian) is still a pending question. Here, we report two new U–Pb detrital zircon datings from sandstone samples in St-Gonlay, giving maximum deposition ages of 551 ± 7 Ma and 540 ± 5 Ma. Although these results do not discard an Ediacaran age for the uppermost Brioverian beds, a Fortunian age is envisioned because the new dating corroborates previous dating from Brittany, Mayenne and Normandy. However, the intervals of error of the radiometric dating, and the dominance of non-penetrative trace fossils associated with matgrounds (an ecology more typical of the Ediacaran Period), do not allow definitive conclusions on the age of the uppermost Brioverian beds.
Adverse childhood experiences and transcriptional response in school-age children
Authors: Marie-Mitchell A. , Cole S.W. 
Published: January 2021

AbstractThis study evaluated whether children with higher adverse childhood experiences (ACE) scores had alterations in immune cell gene expression profiles. RNA sequencing was conducted on dried blood spot samples from 37 generally healthy English-speaking children (age 5–11) who were recruited from well-child visits at a university-affiliated pediatric practice. The Whole Child Assessment was used to assess ACE exposure. Primary analyses examined an a priori-specified composite of 19 pro-inflammatory gene transcripts. Secondary analyses examined a 34-gene composite assessing Type I interferon response, and used Transcript Origin Analyses to identify cellular mechanisms. After controlling for age, body mass index percentile, sex, race/ethnicity, current insurance status, and household smoking exposure, pro-inflammatory gene expression was elevated by 0.094 log2 RNA expression units with each Child-ACE total score point (p = .019). Type I interferon gene expression was similarly upregulated (0.103; p = .008). Transcript origin analyses implicated CD8+ T cell as the primary sources of gene transcripts upregulated, and nonclassical (CD16+) monocytes as sources of downregulated transcripts. These preliminary analyses suggest that parent-reported ACE exposures are associated with increased expression of both inflammatory and interferon gene transcripts in children's circulating blood cells.
The number of maximum primitive sets of integers
Authors: Liu Hong , Pach Péter Pál , Palincza Richárd 
Published: January 2021

AbstractA set of integers is primitive if it does not contain an element dividing another. Let f(n) denote the number of maximum-size primitive subsets of {1,…,2n}. We prove that the limit α = limn→∞f(n)1/n exists. Furthermore, we present an algorithm approximating α with (1 + ε) multiplicative error in N(ε) steps, showing in particular that α ≈ 1.318. Our algorithm can be adapted to estimate the number of all primitive sets in {1,…,n} as well.We address another related problem of Cameron and Erdős. They showed that the number of sets containing pairwise coprime integers in {1,…n} is between ${2^{\pi (n)}} \cdot {e^{(1/2 + o(1))\sqrt n }}$ and ${2^{\pi (n)}} \cdot {e^{(2 + o(1))\sqrt n }}$. We show that neither of these bounds is tight: there are in fact ${2^{\pi (n)}} \cdot {e^{(1 + o(1))\sqrt n }}$ such sets.