bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Profile, Outcome and Risk Factors for Mortality of Neonates Requiring Mechanical Ventilation at Tertiary Care Centre of Central Gujarat, India
Authors: Thakkar Pareshkumar A , Pansuriya Himanshu G , Bharani Sheela , Taneja Khushboo Kamal 
Published: May 2021

Introduction: Mechanical ventilation is an important factor contributing to the reduced neonatal mortality in NICU. However, many ventilated babies are left with detrimental sequelae. This study was undertaken to know the prognostic predictors and survival outcome in the ventilated neonates. We assessed the clinical profile, outcome of mechanical ventilation and analysed the risk factors for mortality and complications resulting from mechanical ventilation.
Methods: A prospective study was conducted at the NICU of a tertiary care hospital in India. The study period was from May 2015 to April 2016. Neonates who underwent mechanical ventilation and met the inclusion criteria were enrolled in the study. Their demographic profile, outcomes and risk factors were documented and analysed using appropriate statistical methods.
Results: 285 neonates required mechanical ventilation during the study period. Among them, 190 were included in the study. Overall mortality was 99 out of the 190 enrolled (52%). The most common indications for mechanical ventilation were Respiratory Distress Syndrome (RDS), Meconium Aspiration Syndrome (MAS) and apnea. Risk factors contributing significantly to higher mortality of ventilated neonates were very low birth weight (VLBW), gestation of less than 32 weeks, shock, ventilator- associated complications like pneumothorax and pulmonary haemorrhage. In multiple regression analysis, very low birth weight, circulatory disturbances, pneumothorax, pulmonary haemorrhage, and higher initial FiO2 requirement were found to be independent risk factors of mortality.
Conclusions: The commonest indications for mechanical ventilation were RDS and MAS. Significantly higher mortality was seen amongst VLBW, preterm neonates. Co-morbidities like circulatory disturbance, and complications like pneumothorax and pulmonary haemorrhage contributed to adverse outcomes.
Study of Upper Pharyngeal Airway Dimension in Young Adults Visiting Orthodontic Department of a Dental College: A Descriptive Cross-sectional Study
Authors: Pradhan Resina , Rajbhandari Anjana , Bajracharya Manju , Manandhar Pushkar , Maharjan Surendra , Pant Bashu Dev 
Published: May 2021

Introduction: Orthodontic treatment may affect the size and position of oropharyngeal structures altering the airway dimension. Airway dimension is considered as one of the parameter of orthodontic diagnosis and treatment planning. Narrow airway passage is associated with sleep disordered breathing. This aims to study about the measurement of upper pharyngeal airway dimension of young Nepalese adults visiting orthodontic department of a dental college.
Methods: This descriptive cross-sectional study conducted at Department of Orthodontics, Peopleâ€™s Dental College and Hospital, Kathmandu. Data was collected from 8th December 2020 to 28th February 2021. Ethical clearance (Reference number. 1, CH100 06, 2077/2076) was taken from Institutional Review Committee of Peoples Dental College and Hospital, Kathmandu, Nepal. Convenient Sampling technique was done. Data was collected and analysis was done using Statistical Packageof Social Sciences 16.
Results: Mean upper pharyngeal airway dimension was 11.40Â±1.84mm and 11.68Â±1.96mm for male and female respectively. Upper pharyngeal airway dimension was found to be almost similar for male and female.
Conclusions: Gender diversity regarding upper pharyngeal airway dimesnion was not observed in this study while other studies also revealed similarities in upper pharyngeal airway dimension between male and female, inspite of larger craniofacial dimension in males than females.
Management of Acute Appendicitis during COVID-19 Pandemic in a Tertiary Care Centre: A Descriptive Cross-sectional Study
Authors: Thapa Basnet Anupama , Singh Suraj , Thapa Bijay , Kayastha Anuj 
Published: May 2021

Introduction: Acute appendicitis is the most common reason for abdominal surgery in children. Though appendectomy considered the gold standard there are a lot of complications related to it. Conservative management of acute appendicitis is not new to medical science. In pandemic like COVID-19 when all the health systems were about to shut-down because of lack of manpower and resources, we started a trial of non-operative management. The main aim of this study is to find out the management of acute appendicitis during COVID-19.
Methods: This was a descriptive cross-sectional study conducted in a tertiary care centre. Data collection was done from the record section which included the patients diagnosed with acute appendicitis from February 2020 to July 2020 after obtaining ethical clearance from Institutional Review Committee. Cases of appendicular lump, appendicular abscess, appendicular perforations have been excluded. Data was collected and entry was done in Statistical Package for the Social Science software version 20, point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data.
Results: The conservative management of acute appendicitis was done in 44 cases (55.7%) while 35 cases (44.3%) had to undergo appendectomy.
Conclusions: COVID-19 can complicate the perioperative course as a result of direct lung injury and multiple organ dysfunctions and can also bring serious threats to the safety of medical staffs involved in managing the acute appendicitis case operatively, so conservative management can be considered as an alternative way of management of acute appendicitis in the pandemic outbreak.
Periodontal microorganisms and diagnosis of malignancy: A cross-sectional study
Authors: Söder Birgitta , Källmén Håkan , Yucel-Lindberg Tülay , Meurman Jukka H. 
Published: May 2021

BACKGROUND: Oral infections associate statistically with cancer. OBJECTIVE: We hypothesized that certain periodontal microorganisms might specifically link to malignancies in general and set out to investigate this in our ongoing cohort study. METHODS: A sample of 99 clinically examined patients from our cohort of 1676 subjects was used to statistically investigate the associations between harboring periodontal microorganisms Aggregatibacter actinomycetemcomitans ( A.a), Porphyromonas gingivalis ( P.g), Prevotella intermedia ( P.i), Tannerella forsythia ( T.f) and Treponema denticola ( T.d). We used oral infection indexes and the incidence figures of malignancies as registered in 2008–2016 in the Swedish National Cancer Register. RESULTS: The pathogen A.a showed strong association with malignancy in 32 out of the 99 patients while P.g and P.i were more prevalent among patients without malignancy. In principal component analyses, A.a appeared in the strongest component while the second strongest component consisted of a combination of T.f and T.d. The third component consisted of a combination of P.g and P.i, respectively. Of basic and oral health variables, gingival index appeared to be the strongest expression of inflammation (Eigen value 4.11 and Explained Variance 68.44 percent). CONCLUSIONS: The results partly confirmed our hypothesis by showing that harboring certain periodontal bacteria might link to malignancy. However, the associations are statistical and no conclusions can be drawn about causality.
Peran Komitmen Organisasional Dalam Pengaruh Kepuasan Kerja Dan Kualitas Kehidupan Kerja Terhadap Kinerja Karyawan PT. Ramayana Lestari Sentosa, Tbk Cabang Sleman
Authors: Kurniawan Ignatius Soni , Nurlita Koni Awes 
Published: May 2021

Penelitian bertujuan untuk mengetahui pengaruh kepuasan kerja dan kualitas kehidupan kerja terhadap kinerja karyawan dengan komitmen organisasional sebagai variabel pemediasi. Penelitian dilakukan terhadap 80 karyawan PT. Ramayana Lestari Sentosa, Tbk Cabang Sleman. Pengumpulan data dilakukan melalui survei dengan kuesioner yang didistribusikan secara offline. Teknik pengambilan sampling dengan sampel jenuh. Jenis penelitian ini bersifat deskriptif kuantitatif. Metode analisis data dengan uji instrumen, uji asumsi klasik, uji hipotesis, dan sobel test. Temuan menunjukkan bahwa kepuasan kerja tidak berpengaruh secara langsung terhadap kinerja karyawan yang dimediasi oleh komitmen organisasional. Ditemukan juga kualitas kehidupan kerja berpengaruh langsung terhadap kinerja dengan dimediasi oleh komitmen organisasional.
Percepção de enfermeiros da rede cegonha sobre sinais do início do trabalho de parto
Authors: Costa Ivelise Fhrideraid Alves Furtado da , Sousa Francisco Stélio de , Ferreira Adriana Gomes Nogueira , Oliveira Fernanda Albuquerque de , Souza Ana Raquel Silva , Guedes Tatiane Gomes , França Inácia Sátiro Xavier de , Baptista Rosilene Santos 
Published: May 2021

Objetivos: Identificar os sinais de início de trabalho de parto, segundo os profissionais da rede cegonha. Metodologia: Trata-se de um estudo transversal, com abordagem de dados primários, realizado em unidades da Rede Cegonha, no período de agosto de 2017 a julho de 2019. A amostragem foi de 84 enfermeiros. A coleta de dados foi efetuada por formulário contendo variáveis de interesse do estudo. Efetuou-se estatística descritiva, para toda a estatística adotou-se o nível de significância de 5%. Esta pesquisa foi aprovada sob-registro CAAE: 87854418.3.0000.5187.Resultados: Quanto aos sinais de início do trabalho de parto foram citados: saída do tampão mucoso, contrações que aumentam sua força constantemente e dor que inicia na região lombar e migra para o púbis (47,94%, n=35).Também foram citadas: contrações uterinas com padrão diferente das recomendações vigentes e perdas vaginais (52,63%, n=40); contrações, perdas vaginais e dilatação (10,52%, n=8); só contrações (15,76%, n=12). Conclusões: Não há apenas um sinal ou sintoma que seja definitivo para identificação do início de trabalho de parto, mas que deve-se levar em consideração a subjetividade e multifatoriedade que envolve o atendimento, reconhecendo cada sinal e sintoma. Sendo necessário o aperfeiçoamento do preparo para o parto a fim de colaborar para uma melhor assistência.
Pneumonia ocasionada pela COVID-19 e a importância do diagnóstico como benefício para o tratamento
Authors: Silva Filho Paulo Sérgio da Paz , Figueiredo Bruno Leonardo de Sousa , Kirchesch Cryshna Letícia , Amaral Salomão Mendes , Santos Lucas Daniel Lima dos , Ferreira João Pedro Nascimento , Farias Maria Divina dos Santos Borges , Batista Woodyson Welson Barros da Silva , Calaça Mickaelle Bezerra , Mesquita Gerardo Vasconcelos , Campelo Vitor Eulálio Sousa , Nascimento Hélio Mateus Silva , Carvalho Neto Amadeu Luis de , Sousa Junior Gilberto dos Santos , Silva Élio Rodrigues da , Cardoso Arquimedes Cavalcante , Serzedo Maria Clara Cronemberger Guimarães , Oliveira Carla Patrícia de Carvalho 
Published: May 2021

O presente estudo teve como objetivo descrever casos de pneumonia ocasionada pela COVID-19 e a importância do diagnóstico como benefício para o tratamento. Trata-se de um estudo descritivo, do tipo revisão integrativa, de caráter qualitativo. O estudo foi realizado nos meses de janeiro a março de 2021 e constituída a partir da identificação do problema e objetivos, elaboração da pergunta norteadora, busca na literatura, avaliação dos dados, análise e síntese de dados e discussão e apresentação dos resultados. As questões da pesquisa foram: “Qual a relação da pneumonia com a COVID-19?", "Qual a importância do diagnóstico rápido da COVID-19?" e "Qual o tratamento empregado em pacientes com pneumonia ocasionada pela COVID-19?". Os critérios de inclusão foram: artigos disponibilizados na íntegra, disponíveis nos idiomas português, espanhol e inglês e publicados entre os anos de 2019 e 2021. Os critérios de exclusão foram: artigos incompletos, cartas ao editor, debates, resenhas, resumos ou artigos publicados em anais de eventos, indisponíveis na íntegra e duplicados. Foram considerados, inicialmente, 346 estudos com a temática proposta; dentre estes, foram excluídos 120 estudos, de acordo com os critérios de exclusão estabelecidos. Após a aplicação dos critérios de inclusão, restaram 12 estudos. O diagnóstico da pneumonia por COVID-19 é possível através de PCR-TR positivo ou presença de alta suspeição clínica (clínica compatível + epidemiologia favorável) associada à tomografia computadorizada com padrão em vidro fosco periférico bilateral de lobos inferiores.
Age, Initial Central Retinal Thickness, and OCT Biomarkers Have an Influence on the Outcome of Diabetic Macular Edema Treated With Ranibizumab– Tri-center 12-Month Treat-and-Extend Study
Authors: Lai Chun-Ting , Hsieh Yi-Ting , Lin Chun-Ju , Wang Jia-Kang , Lin Chih-Ying , Hsia Ning-Yi , Bair Henry , Chen Huan-Sheng , Chiu Chiung-Yi , Weng Shao-Wei 
Published: May 2021

Objective: We report the tri-center 1-year outcomes of a treat-and-extend (T&amp;E) regimen in four-week intervals with ranibizumab for diabetic macular edema (DME).Methods: In this retrospective study, all eyes received 3 monthly loading injections of 0.5 mg ranibizumab, followed by a T&amp;E regimen for DME. Regression models were used to evaluate the associating factors for visual and anatomical outcomes.Results: Ninety one eyes from 64 patients were enrolled. Mean LogMAR best-corrected visual acuity (BCVA) improved from 0.58 at baseline to 0.36 at month 12 and mean central retinal thickness (CRT) decreased from 411 μm at baseline to 290 μm at month 12. Younger age and eyes having thinner baseline CRT, with ellipsoid zone disruption (EZD), and without epiretinal membrane (ERM) were associated with better final CRT. Moreover, eyes with thicker baseline CRT tend to receive more injections. Among the parameters, only having ERM or EZD was associated with significant BCVA recovery.Conclusions: A T&amp;E regimen with ranibizumab by 4-week intervals is effective in improving BCVA and reducing CRT with efficacy notable starting from the third month. Clinical parameters including age, initial CRT, and presence of ERM or EZD significantly influenced therapeutic outcomes. Moreover, the presence of ERM should not preclude DME patients from receiving anti-VEGF therapy. Future studies with larger cohorts are warranted.
Challenges and Opportunities of Intraoperative 3D Ultrasound With Neuronavigation in Relation to Intraoperative MRI
Authors: Bastos Dhiego Chaves De Almeida , Juvekar Parikshit , Tie Yanmei , Jowkar Nick , Pieper Steve , Wells Willam M. , Bi Wenya Linda , Golby Alexandra , Frisken Sarah , Kapur Tina 
Published: May 2021

IntroductionNeuronavigation greatly improves the surgeon’s ability to approach, assess and operate on brain tumors, but tends to lose its accuracy as the surgery progresses and substantial brain shift and deformation occurs. Intraoperative MRI (iMRI) can partially address this problem but is resource intensive and workflow disruptive. Intraoperative ultrasound (iUS) provides real-time information that can be used to update neuronavigation and provide real-time information regarding the resection progress. We describe the intraoperative use of 3D iUS in relation to iMRI, and discuss the challenges and opportunities in its use in neurosurgical practice.MethodsWe performed a retrospective evaluation of patients who underwent image-guided brain tumor resection in which both 3D iUS and iMRI were used. The study was conducted between June 2020 and December 2020 when an extension of a commercially available navigation software was introduced in our practice enabling 3D iUS volumes to be reconstructed from tracked 2D iUS images. For each patient, three or more 3D iUS images were acquired during the procedure, and one iMRI was acquired towards the end. The iUS images included an extradural ultrasound sweep acquired before dural incision (iUS-1), a post-dural opening iUS (iUS-2), and a third iUS acquired immediately before the iMRI acquisition (iUS-3). iUS-1 and preoperative MRI were compared to evaluate the ability of iUS to visualize tumor boundaries and critical anatomic landmarks; iUS-3 and iMRI were compared to evaluate the ability of iUS for predicting residual tumor.ResultsTwenty-three patients were included in this study. Fifteen patients had tumors located in eloquent or near eloquent brain regions, the majority of patients had low grade gliomas (11), gross total resection was achieved in 12 patients, postoperative temporary deficits were observed in five patients. In twenty-two iUS was able to define tumor location, tumor margins, and was able to indicate relevant landmarks for orientation and guidance. In sixteen cases, white matter fiber tracts computed from preoperative dMRI were overlaid on the iUS images. In nineteen patients, the EOR (GTR or STR) was predicted by iUS and confirmed by iMRI. The remaining four patients where iUS was not able to evaluate the presence or absence of residual tumor were recurrent cases with a previous surgical cavity that hindered good contact between the US probe and the brain surface.ConclusionThis recent experience at our institution illustrates the practical benefits, challenges, and opportunities of 3D iUS in relation to iMRI.
Centhaquine Restores Renal Blood Flow and Protects Tissue Damage After Hemorrhagic Shock and Renal Ischemia
Authors: Ranjan Amaresh K. , Zhang Zhong , Briyal Seema , Gulati Anil 
Published: May 2021

Background: Centhaquine (CQ) (Lyfaquin®) is in late stage clinical development as a safe and effective first-in-class resuscitative agent for hemorrhagic shock patients (NCT02408731, NCT04056065, and NCT04045327). Acute kidney injury (AKI) is known to be associated with hemorrhagic shock. Hence, effect of CQ on protection of kidneys from damage due to hemorrhagic shock was investigated.Methods: To assess effect of CQ on AKI in shock, we created a rat model with hemorrhagic shock and AKI. Renal arteries were clamped and de-clamped to induce AKI like ischemia/reperfusion model and hemorrhage was carried out by withdrawing blood for 30 min. Rats were resuscitated with CQ (0.02 mg/kg) for 10 min. MAP, heart rate (HR), and renal blood flow (RBF) were monitored for 120 min.Results: CQ produced a significant improvement in RBF compared to vehicle (p&lt; 0.003) even though MAP and HR was similar in CQ and vehicle groups. Blood lactate level was lower (p = 0.0064) in CQ than vehicle at 120 min post-resuscitation. Histopathological analysis of tissues indicated greater renal damage in vehicle than CQ. Western blots showed higher HIF-1α (p = 0.0152) and lower NGAL (p = 0.01626) levels in CQ vs vehicle. Immunofluorescence in the kidney cortex and medulla showed significantly higher (p&lt; 0.045) expression of HIF-1α and lower expression of Bax (p&lt; 0.044) in CQ. Expression of PHD 3 (p&lt; 0.0001) was higher, while the expression of Cytochrome C (p = 0.01429) was lower in the cortex of CQ than vehicle.Conclusion: Results show CQ (Lyfaquin®) increased renal blood flow, augmented hypoxia response, decreased tissue damage and apoptosis following hemorrhagic shock induced AKI, and may be explored to prevent/treat AKI.Translational Statement: Centhaquine (CQ) is safe for human use and currently in late stage clinical development as a first-in-class resuscitative agent to treat hemorrhagic shock. In the current study, we have explored a novel role of CQ in protection from hemorrhagic shock induced AKI, indicating its potential to treat/prevent AKI.
Symptomatic Premature Ventricular Contractions in Vasovagal Syncope Patients: Autonomic Modulation and Catheter Ablation
Authors: Zheng Lihui , Sun Wei , Qiao Yu , Hou Bingbo , Guo Jinrui , Killu Ammar , Yao Yan 
Published: May 2021

IntroductionThere has been limited reports about the comorbid premature ventricular contractions (PVCs) and vasovagal syncope (VVS). Deceleration capacity (DC) was demonstrated to be a quantitative evaluation to assess the cardiac vagal activity. This study sought to report the impact of autonomic modulation on symptomatic PVCs in VVS patients.Methods and ResultsTwenty-six VVS patients with symptomatic idiopathic PVCs were consecutively enrolled. Identification and catheter ablation of left atrial ganglionated plexi (GP) and PVCs were performed in 26 and 20 patients, respectively. Holter 24 h-electrocardiograms were performed before and after the procedure to evaluate DC and PVCs occurrence. Eighteen patients were subtyped as DC-dependent PVCs (D-PVCs) and eight as DC-independent PVCs groups (I-PVCs). In D-PVCs group, circadian rhythm of hourly PVCs was positively correlated with hourly DC (P &lt; 0.05) while there was no correlation in I-PVCs group (P &gt; 0.05). Fifty-three GPs with positive vagal response were successfully elicited (2.0 ± 0.8 per patient). PVCs failed to occur spontaneously nor to be induced in six patients. In the remaining 20 patients, PVCs foci identified were all located in the ventricular outflow tract region. Post-ablation DC decreased significantly from baseline (P &lt; 0.05). During mean follow-up of 10.64 ± 6.84 months, syncope recurred in one patient and PVCs recurred in another. PVCs burden of the six patients in whom neither catheter ablation nor antiarrhythmic drugs were applied demonstrated a significant decrease during follow-up (P = 0.037).ConclusionAutonomic activities were involved in the occurrence of symptomatic idiopathic PVCs in some VVS patients. D-PVCs might be facilitated by increased vagal activities. Catheter ablation of GP and PVCs foci may be an effective, safe treatment in patients with concomitant VVS and idiopathic PVCs.
PENGARUH KONSENTRASI LARUTAN DAUN JAMBU BIJI (Psidium guajava) DAN LAMA PERENDAMAN TERHADAP KUALITAS TELUR AYAM RAS
Authors: Ernawati Tri , Karisoh Linda Ch. M. , Hadju Rahmawaty , Siswosubroto Surtijono E. 
Published: May 2021

THE EFFECT OF GUAVA LEAF SOLUTION CONCENTRATION AND SOAKING DURATION ON THE QUALITY OF CHICKEN EGGS. This study aims to determine the effect of guava leaf solution concentration and soaking time on the quality of chicken eggs. This research was conducted from November to December 2018, at the Laboratory of Animal Product Technology, Faculty of Animal Husbandry, Sam Ratulangi University, Manado. The method used is Completely Randomized Design (CRD) with a factorial pattern consisting of 2 factors. Factor A was the concentration of solution of guava leaves and factor B is the length of immersion with 4 replications. The treatments used are: Factor A concentration of solution of guava leaves A1 = 3%, A2 = 6%, A3 = 9%, A4 = 12%. Factor B was duration of immersion B1 = 6 hours, B2 = 12 hours, B3 = 18 hours, B4 = 24 hours. The variables analyzed were a decrease in egg weight, egg white index and egg yolk index. Data obtained were analyzed by variety. If there are significant differences between treatments, it will be continued with Duncan Test. The results of the variance analysis showed that the interaction had a significant effect (P <0.05) on the decrease in egg weight and did not significantly influence (P> 0.05) on the egg white index and egg yolk index. Duncan's Test results for decreasing egg weight showed the concentration of guava leaf solution 3% and soaking time 6 hours gave good results for the quality of chicken eggs. It was concluded that the concentration of 3% and the soaking time of 6 hours gives good results on decreasing egg weight. As for the egg white index and egg yolk index showed good results with concentration of 12% and 24-hour immersion time. Keywords: Guava leaf, Egg weight, Egg white index, Egg yolk index.