bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptional and Post-Transcriptional Alterations of I κBα in Active Minimal-Change Nephrotic Syndrome
Authors: SAHALI DJILLALI , PAWLAK ANDRÉ , GOUVELLO SABINE LE , LANG PHILIPPE , VALANCIUTÉ ASTA , REMY PHILIPPE , LOIRAT CHANTAL , NIAUDET PATRICK , BENSMAN ALBERT , GUELLAEN GEORGES 
Published: April 2021

Abstract.
Minimal-change nephrotic syndrome (MCNS) is a renal disease characterized by heavy glomerular proteinuria and increased production of cytokines by immune cells. Because of the central role of nuclear factor-κB (NF-κB) in the regulation of cytokine expression, its activity during the relapse and remission phases of steroid-sensitive MCNS was analyzed. During relapse, nuclear extracts from peripheral blood mononuclear cells displayed high levels of NF-κB DNA-binding activity, consisting primarily of p50/RelA (p65) complexes. NF-κB p65 and IκBα proteins were barely detected or not detected in cytosolic fractions during relapse, in contrast to remission. The lack of expression of IκBα protein was associated with downregulation of IκBα mRNA and increases in the levels of the mRNA encoding the proteasome α2 subunit proteolytic pathway. In addition, inhibition of proteasome activity induced cytosolic accumulation of phosphorylated IκBα and significant reductions in the NF-κB binding activity in nuclear extracts from peripheral blood mononuclear cells from patients experiencing relapses. These results suggest that alterations in the NF-κB/IκBα regulatory feedback loop may contribute to the immunologic abnormalities that occur in steroidsensitive MCNS.
Pharmacologic Modulators of Nitric Oxide Exacerbate Tubulointerstitial Inflammation in Proteinuric Rats
Authors: RANGAN GOPALA K. , WANG YIPING , HARRIS DAVID C. H. 
Published: April 2021

Abstract.
Nitric oxide (NO) regulates inflammatory responses partly by cell-specific inhibition of the transcription factor nuclear factor κB (NF-κB). This study investigated the effect of continuous oral administration of an NO donor (molsidomine [Mol]), NO precursor (L-arginine [L-arg]), or selective inhibitors of inducible NO synthase (iNOS; aminoguanidine [AG], L-N
6-(1-iminoethyl)lysine [L-NIL]) on the progression of tubulointerstitial inflammation and NF-κB activation in a non-immune model of chronic glomerular disease (Adriamycin nephropathy [AN]), from day 8 until day 30 after disease induction. On day 30, rats with AN had heavy proteinuria, reduced creatinine clearance, and tubulointerstitial disease. Treatment with both AG and L-NIL exacerbated the progression of AN as evidenced by (1) increased renal cortical malondialdehyde; (2) reduced creatinine clearance; and (3) increased tubular atrophy, interstitial volume, and monocyte infiltration. Unexpectedly, Mol also increased renal malondialdehyde and worsened tubular injury, whereas L-arg had no effect. The increase in renal cortical NF-κB activation in AN was not altered by AG, L-NIL, or Mol, but the mRNA expression of monocyte chemoattractant protein-1, interleukin-10, and osteopontin were elevated in these groups. Nitrite release from kidney slices reduced in AN. Treatment with Mol restored renal nitrite release to normal, whereas neither L-arg nor the NOS inhibitors had an effect. It is concluded that endogenous iNOS-derived NO has a protective role against tubulointerstitial injury and cytokine production in AN. However, the pro-oxidant activity of NO donors may limit their potential benefit in proteinuric renal disease.
Screening for Subclinical Stenosis in Native Vessel Arteriovenous Fistulae
Authors: TONELLI MARCELLO , JINDAL KAILASH , HIRSCH DAVID , TAYLOR SANDRA , KANE CHRISTOPHER , HENBREY SUSAN 
Published: April 2021

Abstract.
Guidelines recommend the use of ultrasound dilution techniques (UDT), including measurement of access recirculation (AR) and access blood flow (Qa), to screen for subclinical vascular access dysfunction. Although these techniques are efficacious in polytetrafluoroethylene grafts, data in native vessel arteriovenous fistulae (AVF) are lacking. A prospective observational study was conducted to evaluate the utility of UDT screening in AVF. Qa and AR were measured bimonthly. Positive studies required fistulograms and were defined by Qa < 500 ml/min, ΔQa > 20% from baseline or AR > 5%. Accesses with stenosis underwent percutaneous angioplasty. After 1 yr, there were 1355 mo of follow-up in 177 patients. There were 44 positive studies in 40 patients. Qa was <500 ml/min in 36 (82%), ΔQa was >20% in 5 (11%), and AR was >5% in 6 (14%). Of patients with Qa < 500 ml/min, 29 (81%) had stenosis. Only two patients (40%) with ΔQa > 20% but Qa > 500 ml/min had stenosis. No patient with AR > 5% had stenosis unless Qa was also <500 ml/min. Immediate patency rate was 93% post-PTA. Mean Qa increased from 303 ± 154 ml/min to 602 ± 220 ml/min (P < 0.0001), and mean urea reduction ratio increased from 70.4 ± 8.4% to 74.6 ± 6.5% (P = 0.003) post-PTA. The results demonstrate that UDT could detect subclinical stenoses in AVF, and most lesions were amenable to angioplasty. AVF that underwent PTA delivered higher Qa and urea reduction ratio, and immediate patency rates were acceptable. Access failure after negative UDT was unusual. Measuring AR increases the time required to perform UDT but does not improve utility. Serial measurements of Qa alone may be the best strategy for screening AVF.
Recipient Age and Weight Affect Chronic Renal Allograft Rejection in Rats
Authors: LIU SHANYING , LUTZ JENS , ANTUS BALAZS , YAO YOUSHENG , BAIK SOHYUN , ILLIES FRIEDERIKE , HEEMANN UWE 
Published: April 2021

Abstract.
Nephron doses and immune responses change with age. Therefore, age is a potential risk factor for graft survival after kidney transplantation. The aim of this study was to determine whether age-related differences are of importance for long-term outcomes after renal transplantation. Kidneys from Fisher 344 rats were orthotopically transplanted into nephrectomized Lewis rats. Kidneys were transplanted using donors and recipients of three age levels, i.e., young (8 wk of age), adult (16 wk of age), and old (40 wk of age). Rats were killed 24 wk after transplantation, and functional, morphologic, and molecular evaluations were performed. Recipient age, rather than donor age, determined graft survival rates. No significant correlation was observed between donor kidney weight on the day of transplantation and morphologic results. Advanced recipient age was associated with reduced creatinine clearance, more severe histologic injuries, including extended glomerular sclerosis, interstitial fibrosis, and vascular lesions, more pronounced cellular infiltration, and greater expression of transforming growth factor-β and platelet-derived growth factor A and B chains. Although no significant correlation between donor age or kidney weight on the day of transplantation and morphologic results was observed, there was a significant correlation between recipient body weight on the day of transplantation and allograft injury. It is concluded that recipient age and weight affect chronic renal rejection. Renal allografts may benefit from young recipient age but may deteriorate in old recipients, suggesting effects of recipient functional demand on long-term outcomes.
Rats Injected with Syngenic Rat Apoptotic Neutrophils Develop Antineutrophil Cytoplasmic Antibodies
Authors: PATRY YAE[Combining Diaeresis]L C. , TREWICK DAVID C. , GREGOIRE MARC , AUDRAIN MARIE A. P. , MOREAU ANNE M. N. , MULLER JEAN-YVES , MEFLAH KHALED , ESNAULT VINCENT L. M. 
Published: April 2021

Abstract.
Antineutrophil cytoplasmic antibodies (ANCA) are present in sera from patients with various forms of vasculitis-associated glomerulonephritis. Because autoantibodies may be directed against antigens presented by apoptotic cells, generation of ANCA using apoptotic neutrophils (PMN) in syngenic Brown Norway (BN) rats was attempted. These rats are T-helper type 2-prone animals, already used successfully in other ANCA-positive animal models. BN rats received repeated injections of buffer or of nonapoptotic or apoptotic PMN aged in cultures, in the footpad and once intravenously. Four of five rats that received injections of PMN aged for 48 h developed ANCA, which cross-reacted with human leukocyte elastase in three cases. None of the rats that received injections of freshly isolated neutrophils developed ANCA. One rat that received buffer injection and that exhibited chronic skin infection developed delayed ANCA. None of the rats showed signs of disease: no weight loss and no proteinuria. Then a subnephritogenic dose of antibody directed against rat glomerular basement membrane was injected. Rats then were killed, and different organs were frozen and studied. No significant lesions were found in kidneys or lungs. It is concluded that injections of apoptotic but not freshly isolated PMN can generate ANCA in BN rats. Additional studies are needed to elucidate the immunization mechanism and the ability of these autoantibodies to initiate vasculitis in these experimental animals.
Intervención de conservación y restauración de un arca de novia catalana del siglo XVI
Authors: Paret Pey Josep , Zornoza Esteban Jesús 
Published: April 2021

El Centre de Restauració de Béns Mobles de Catalunya (CRBMC) ha realizado la conservación y restauración de un cofre de novia catalán de madera policromada. Antes de la intervención se realizó un completo estudio preliminar. Este estudio comienza con un análisis fotográfico con diferentes tipos de iluminación: luz visible (luz difusa aplicada de diferentes formas, con más o menos detalle y luz rasante) y radiación invisible (luz ultravioleta e infrarroja), para finalizar con la radiografía. Estas técnicas de examen se complementan con análisis fisicoquímicos, que permiten obtener información específica sobre sus materiales constituyentes.
Finalmente, se trata de poner estos análisis a disposición de los conservadores para profundizar en el conocimiento de la obra y poder hacer una mejor propuesta de conservación y restauración. De la misma forma, puede ser útil para los historiadores del arte para determinar atribuciones, fechas o identificar la veracidad o falsedad de las mismas.
Dinamización del patrimonio literario: usos culturales de la leyenda = Dynamization of the Literary Heritage: Cultural Uses of the Legend
Authors: Vega Rodríguez Pilar 
Published: April 2021

A partir de la investigación del proyecto DLLHO_19, este trabajo reflexiona sobre el valor patrimonial de la leyenda (oral o literaria) y sobre los usos culturales que pueden colaborar a la conservación y dinamización de este activo, junto con la trascendencia del legendario en las investigaciones sobre geografía literaria.Based on the research project DLLHO_19, in this paper we reflect on the heritage value of the legend (oral or literary) and on the cultural uses that can contribute to the conservation and dynamization of this asset, together with the transcendence of the legendary in the investigations on literary geography.
JAVIER RODRÍGUEZ MARCOS, Vida secreta, Barcelona, Tusquets (Col. Nuevos Textos Sagrados), 2015, 75 pp.
Authors: Abril Juan Carlos 
Published: April 2021

Reseña de JAVIER RODRÍGUEZ MARCOS, Vida secreta, Barcelona, Tusquets (Col. NuevosTextos Sagrados), 2015, 75 pp.
Results of minimally invasive quick definitive fixation of unstable bony pelvic disruption by combined retrosacral transiliac rods and anterior external fixator during a critical national period
Authors: Khamis Ahmed Refaat , Shoulah Saad Abdelreheem 
Published: April 2021

<p class="abstract">Unstable pelvic ring fractures are challenging injuries regarding their reduction and stabilization. The presented study evaluates the results of a minimally invasive and quick one-stage stabilization of sacral fractures combined with bilateral pubic rami fractures during a period of national limited resources and decreased general security aiming at reduction of the duration of hospital stay and overall costs. Sixteen patients with unilateral sacral fractures and bilateral pubic rami fractures without lumbosacral dissociation were fixed by two retrosacral threaded transiliac rods and an anterior external fixator. Results were assessed with Majeed score and Matta-Tornetta radiologic criteria for post-operative reduction. The follow up period averaged 23 months. There were 9 cases excellent, 4 cases good and 3 cases fair. The duration of surgery and the number of intra-operative X-ray images were recorded. The presented technique is simple, reproducible and quick for one-stage fixation of the unstable pelvic bony disruption. It reduces the operative time, radiation exposure, duration of hospital stays and cost of care during a critical national period with limited resources. </p>
Osteonecrosis of bilateral femoral head in a post COVID-19 patient: case report
Authors: Chacko Ankith , Babu Murukan , Thomas Dibin K. 
Published: April 2021

<p class="abstract">Osteonecrosis of the femoral head, can be secondary to various causes, which can be traumatic or atraumatic. The corticosteroid used is a common cause of non-traumatic osteonecrosis. Various viral infections have been documented to cause osteonecrosis, none of the studies report COVID-19. 23-year-old gentleman diagnosed with COVID-19. He received steroid injections as a part of treatment. Nearly after two months, he was diagnosed to have stage II osteonecrosis of both femoral heads. The cumulative dose of steroid given to the patient was not enough to consider diagnosis of steroid associated osteonecrosis of femoral heads. The combination hypercoagulability, inflammation of blood vessels, and leukocyte/platelet aggregation associated with COVID-19 might have contributed to the development of osteonecrosis in this case. So, it is also important to consider osteonecrosis as an important differential if a patient with past history of COVID-19 come with hip pain.</p>
Sistema Regional de Inovação: uma análise sobre os estados do Pará e do Amazonas
Authors: Costa Arthur Phillip Alberth Marques Da , Farias Hilder André Bezerra , Diniz Márcia Jucá Teixeira 
Published: April 2021

A literatura direciona a inovação como resultado de ambiente favorável capaz de mobilizar diferentes agentes com contribuições multidisciplinares que fortaleçam uma cultura inovadora nas firmas locais. O presente artigo aborda a literatura existente sobre Sistemas de Inovação e os seus desdobramentos com o objetivo de entender a relação entre o ambiente interno das firmas e o seu relacionamento com outras organizações nos estados do Amazonas e Pará. Foram extraídos dados da PINTEC, com o intuito de estudar as parcerias locais, rotinas organizacionais, padrões diferenciados de esforços tecnológicos e obstáculo reconhecidos por essas empresas. As pesquisas são dos anos de 2000, 2003, 2005, 2009, 2011 e 2014. Como resultado observou-se que há melhora no desempenho das firmas inovadoras, ainda que o ambiente institucional apresente fragilidades e pouca interação nas relações entre Universidade-Governo-Indústria.
Food for Thought: Culturally Diverse Older Adults' Views on Food and Meals Captured by Student-Led Digital Storytelling in the Bronx
Authors: McGovern Justine , Burt Katherine Gardner , Schwittek David 
Published: April 2021

ObjectiveThrough the lens of a digital storytelling project exploring food traditions, social connectedness, and aging among diverse older adults, this article demonstrates how innovative pedagogies can contribute to developing a more culturally responsive workforce better prepared to meet evolving needs of diverse urban communities.MethodsIn the fall of 2017, 25 undergraduate students enrolled in an interdisciplinary gerontology practice course engaged in a digital storytelling project to explore food traditions and social connectedness among older adults living in the Bronx.ResultsThe stories underscore the importance of food and meals in everyday life, particularly for people growing old far from their home of origin. The words and images indicate that food practices can assert identity, sustain cultural ties and social connectedness, and mediate losses both physical and emotional.ConclusionsThe article suggests that integrating innovative pedagogies across health profession curricula and fostering interdisciplinary and interprofessional collaborations are two ways to better meet client needs. Moreover, providing opportunities for experiential learning extends higher education's commitment to integrating best practice pedagogies across the curriculum.
Ulama dalam Penguatan Politik Identitas Perspektif Al-Qur’an
Authors: Sulfa Nafilah 
Published: April 2021

‘Ulama are commanding religious figures with far-reaching knowledge; however, currently the term ‘ulama is distorted by unscrupulous people. Frequently, Ulama’s behaviors do not reflect their prestige as Prophet’s heir even though having a number of fanatical adherents. Their fatwa has authoritative influence in establishing post-truth narration. It can cause a horizontal gap and segregation in society if their fatwas are not true. This crisis affected by the increase of identity politics during pre-post political contestation. Meanwhile, the hugest disadvantages are beared by whose tend to believe in their thoughts and behaviors. We analyzed this phenomenon from the perspective of the Qur'an on the meaning of the term ‘ulama and their role in identity politics involvement. We used sociological-normative and descriptive-phenomenological methods to reread some related verses. This study showed, for example, refered to Q.S. Ali ‘Imran (3): 104, ‘ulama are allowed to have an active and positive role in the sphere of politics.
Editorial - Boas Práticas em Pesquisa e a prevenção da má conduta acadêmica
Authors: Suzigan Wilson , Garcia Renato , Massaro Tatiana 
Published: April 2021

Nas últimas décadas, temos observado uma crescente inquietação com a má conduta acadêmica (academic misconducting) e com o aumento da ocorrência de fraudes nas atividades de pesquisa. Atualmente, este tema representa um desafio permanente para a equipe editorial de qualquer revista acadêmica. O assunto ganhou relevância também em diversas instituições ligadas à pesquisa propriamente acadêmica, como universidades, indexadores de periódicos, bases de dados e agências de fomento. Estas instituições vêm reforçando a importância da disseminação de Boas Práticas em Pesquisa e adotando mecanismos que visam desestimular as práticas de má conduta. Neste editorial abordamos esse assunto, tendo em vista as discussões que têm emergido no Brasil e no âmbito da própria Revista Brasileira de Inovação.
THE EFFECT OF CORN SILK EXTRACT (Zea mays) AS BIOLARVICIDES OF Aedes aegypti MOSQUITO LARVAE IN EFFORTS TO CONTROL SPREAD OF DENGUE HEMORRHAGIC FEVER
Authors: Wahyudi Rahmad , Indriani Harfina , Abror Yogi 
Published: April 2021

Dengue hemorrhagic fever (DHF) is still a serious health problem in the community. DHF is caused by the dengue virus (DENV) and is transmitted by the Aedes aegypti (Ae. aegypti) mosquito, which is the main vector for the virus. In controlling DHF vectors, larvicides are still used. These larvicides contain chemical compounds that have negative side effects affecting the human body. Therefore, there is a need for natural-based larvacides (biolarvicides). The purpose of this study was to determine the potential of corn silk as a biolarvicide against dengue vector larvae (Aedes aegypti). This study was carried out at the STIKes Ngudia Husada Madura Bangkalan Laboratory and was done by taking corn silk waste samples disposed of as waste from corn farmers and corn traders in Bangkalan Regency. A Thousand samples of Aedes aegypti larvae that had reached instar III were used and divided into five test groups, namely 0 g/L (control), 6.25 g/L, 12.5 g/L, 25 g/L, and 50 g/L . Each group contained 200 larvae. The experiment was repeated 3 times. Data of the number of deaths of Aedes aegypti larvae were collected every 24 hours. The highest dose that could kill Aedes aegypti larvae was at 20 g/L.Keywords : biolarvicides, corn silk, larvae, Aedes aegypti
Expansion and Reduction of Soft Sets and their Applications in Decision Making
Authors: Cagman Naim , Eraslan Selim 
Published: April 2021

Abstract
In this study, we first define expansion and reduction of the soft sets that are based on the linguistic modifiers. By using these new notions we then construct a decision making method called soft reduction method, which selects a set of optimum alternatives. We finally present an example which shows that the methods can be successfully applied to many problems containing uncertainties.
Carbon dioxide abatement in China: Revisiting the role of renewable energy, financial development and urbanization from Quantile ARDL approach
Authors: Sharif Arshian , hussain Hamid , Musibau Hammed Oluwaseyi , Sinha Avik 
Published: April 2021

Abstract
The current study re-investigates the link between renewable power utilization, financial advancements, urbanization and carbon emanations by applying the newly introduced quantile autoregressive distributed lag (QARDL) method proposed by Cho et al. (2015) in Chinese economy. The framework is assessed utilizing quarterly data during the time span of 1970Q1-2017Q4. The outcomes confirm that the association between the variable is quantile-dependent, which may uncover ambiguous outcomes in the previous research using out-dated estimations that mainly focus on the mean. The outcomes of Wald-test further confirmed the parameter constancy for China. Interestingly, we have found that on the one hand, renewable energy utilization helps in declining the CO2 emanations, and on the other hand, financial advancement and urbanization augments the CO2 emanations. Moreover, the causality analysis results divulge the existence of bidirectional causal associations between (a) renewable power and Carbon emanations, (b) financial advancements and Carbon emanations, and (c) urbanization and Carbon emanations. The findings recommended that government enforcement of renewable energy implementation should entail the introduction of cleaner production processes across the industries, so the level of environmental awareness helps the citizens in identifying the ecologically sustainable utilization patterns.
Nanopore sequencing of tomato mottle leaf distortion virus, a new bipartite begomovirus infecting tomato in Brazil
Authors: Martins Thais Pereira , Souza Tadeu Araujo , Silva Patricia Santos , Nakasu Erich Yukio Tempel , Melo Fernando Lucas , Inoue-Nagata Alice Kazuko , Nagata Tatsuya 
Published: April 2021

Abstract
During a survey in a tomato field in Luziânia (Goiás State, Brazil), a plant showing mottling, chlorotic spots, and leaf distortion was found. A new bipartite begomovirus was found by Nanopore sequencing, and the full DNA-A sequence was confirmed by Sanger sequencing. The highest nucleotide identity match of this DNA-A genome (2596 bases) was 81.65% with tomato golden leaf deformation virus (HM357456). Due to the current species demarcation criterion of 91% of nucleotide identity (DNA-A), we propose it as a new member of the genus Begomovirus, named Tomato mottle leaf distortion virus.