bluuebunny/crossref_metadata_2025_split huggingface dataset:
ТЕОРИЯ П. ВИРНО: КОММУНИКАЦИЯ, НОВАЯ ПУБЛИЧНОСТЬ, ДЕМОКРАТИЯ
Authors: Наумова Е. И. 
Published: March 2021

The article is about the key moments of the theory of post-operaist philosopher Paolo Virno in connection with the concepts of nonmaterial economy and general intellect. The theory of post-operaism is based on the judgment that, from the one hand, communication becomes the leading mean of production and increment of capital in the frame of Post-Fordist capitalism; from the other hand, communication as the mode of production of «common» can be the foundation for the labor autonomy from capital and emergence the new types of democracy. The borders between labor (poesis), political activity (praxis) and intellect (life of Mind) blur in the frame nonmaterial economy functioning. As a result, we have deal with the situation of politization of labor and highlighting the phenomenon of virtuosity as a key competence in the new type of capitalism. Connection between labor and politics moves the labor activity in to category of public action that build new understanding of publicity based on the mastery of language and communication. Marх’s sustained division of labor on productive and unproductive, where the last isn’t able to create surplus value, gets the new conceptualization in the frame of post-operaist theory. Contemporary communicative capitalism has shown that the intellectual worker-virtuoso can make surplus value in the frame of cultural industry development, the «life» labor serves the capital in such situation. But, at the same time, the virtuoso linguistic activity as the basis of nonmaterial economy can become the foundation for the new types of democracy, which differ from the project of neoliberal democracy, where labor gets the characteristics of political action and receives the autonomy from capital. The concept of labor as virtuoso political action based on the idea of interactive and communicative foundation of politics which can to create the new space of publicity using the communicative technologies. These technologies empower the realization of participatory democratic processes for the citizens in the frame of political life and provide type of political interaction which sets out the continuity of the process of production of common knowledge, ideas, communications, relationships and finance as the basis for the new type of democracy. All of that promote the manifestation of communist (production of «common») tendencies in cooperative functioning of knowledge, communication and capital.
Problems of theory and history of teaching philological disciplines in Russia
Authors: Волков Александр Александрович 
Published: March 2021

В статье рассматриваются проблемы теории и истории преподавания филологических дисциплин в России в связи с развитием теории языка и культурной политики государства. Предлагается обоснование преподавания риторики как средства развития культуры мышления и противостояния манипулятивной практике средств массовой коммуникации.
The article considers the problems of theory and history of teaching philological disciplines in Russia in connection with the development of language theory and state cultural policy. A rationale for teaching rhetoric as a means of developing a culture of thinking and resisting the manipulative practices of mass communication is offered.
Some aspects of diary research methodology
Authors: Якубов Андрей 
Published: March 2021

В статье представлена попытка предложить методологическую базу для исследования дневников как эго-текстов на базе богословского образования. Автор показывает актуальность исследования дневникового жанра, объясняя её современными тенденциями отечественного литературоведения. Предлагаются элементы возможного плана для написания исследования текстов дневникового жанра. Обозначена связь элементов эго-текстов с личностью их авторов. Показана широкая возможность для дальнейшего изучения дневников в богословской школе.
The article presents an attempt to propose a methodological basis for the study of diaries as ego-texts on the basis of theological education. The author shows the relevance of the study of the diary genre, explaining it by the current trends of domestic literary studies. Elements of a possible plan for The elements of a possible plan for writing a research of diary genre texts are proposed. The connection between the elements of ego-texts and the personality of their authors is outlined. A broad possibility for further study of diaries in theological schools is shown.
PHONETIC ZEROITATION AT KAERA AND TEIWA LANGUAGE
Authors: Sanubarianto Salimulloh Tegar 
Published: March 2021

Abstract
This study aims to identify some of the phonetics change rules of Kaera and Teiwa languages. Therefore, this research uses mix methods. Quantitative methods used to determine the level of differences of Kaera and Teiwa languages. Qualitative methods are used to determine the rules about phonetic changes of both languages. Data collection uses advanced techniques and records with the main instrument 200 Swadesh vocabulary. The data collected were then analyzed using the dialectometry technique to determine the level of differences of Kaera and Teiwa languages, while the Padan Intralingual Crowley technique to determine the rules about phonetic changes of Kaera and Teiwa language. The result of dialectometry analysis shows that the level of differences of Kaera and Teiwa languages ​​is 29—35,5%, meaning the two languages ​​are included in the cognate category. Furthermore, in the vocabulary of Kaera and Teiwa language cognates, zeroization, namely aferesis and apokop are found.
Keywords: Kaera, Teiwa, phonetic change
Farinha de sementes germinadas de abóbora: Aspectos físicos, físico-químicos e colorimétricos
Authors: Amadeu Lumara Tatiely Santos , Queiroz Alexandre José de Melo , Figueirêdo Rossana Maria Feitosa de , Paiva Yaroslávia Ferreira , Ferreira João Paulo de Lima , Reis Carolaine Gomes dos , Silva Renato Costa da , Araújo Karoline Thays Andrade , Coelho Nycolle Oliveira , Carneiro Ely Félix de Sá 
Published: March 2021

A abóbora (Cucurbita moschata) é uma hortaliça apreciada por pessoas de todos os níveis de renda, porém, suas sementes são descartadas, caracterizando um desperdício em virtude da sua rica composição nutricional. Uma das formas de minimizar esse descarte é disponibilizar alternativas de uso da semente, aumentando seu atrativo para industrialização e consequentemente as possibilidades da sua aplicação na elaboração de alimentos para o consumo humano. Desse modo, objetivou-se avaliar as características físicas, fisico-quimicas e colorimétricas das sementes de abóbora in natura, germinadas e da farinha da semente de abóbora germinada. As amostras foram caracterizadas quanto a massa específica unitária, real e aparente, porosidade, cor, volume, comprimento, largura, espessura, circularidade, esfericidade, teor de água, atividade de água, pH, acidez total titulável, cinzas, lipídios, proteínas, açucares totais e redutores, determinou-se ainda as isotermas de adsorção de umidade das farinhas secas em temperaturas de 20, 25 e 30º C. Verificou-se que o modelo de Peleg, seguido do modelo de Oswin, foram os que apresentaram os melhores ajustes aos dados experimentais. A germinação alterou a massa unitária, porosidade, os parâmetros colorimétricos e gerou um aumento considerável no teor de proteínas. A secagem provocou transformações na massa unitária, porosidade, circularidade e esfericidade. Quanto aos parâmetros físico-químicos, houve redução do pH e açucares redutores e aumento dos teores de lipídios e proteínas. Sendo assim, a farinha de semente de abóbora germinada apresentou bons resultados, principalmente em relação ao teor de proteínas, apresentando-se como uma boa alternativa para o desenvolvimento de novos produtos.
Dificuldades enfrentadas pelos professores da Educação de Jovens e Adultos de um município do interior de Mato Grosso
Authors: Oliveira Leilane Alves de , Guilardi Junior Felício , Oliveira Julio Martinez Alves , Oliveira Jessica Alves de , Oliveira Rosângela Aparecida Alves Martinez de , Petrilli Pedro Henrique , Saliba Tânia Adas 
Published: March 2021

Este trabalho foi realizado na escola em uma escola pública de Sinop,Mato Grosso, Brasil, no ano de 2011 e tem como objetivo identificar como se desenvolve o processo de ensino e aprendizagem e os problemas enfrentados pelos docentes. Para isso, foi feito pesquisa bibliográfica e de campo com uma amostra de professores e alunos que lecionam e frequentam, respectivamente a escola , sendo aplicados questionários com perguntas abertas e fechadas. As informações obtidas a partir desse levantamento, forneceram dados sobre os reais problemas presentes na Educação de Jovens e Adultos. Através dos questionários aplicados aos alunos constatou-se que 57% pertencem ao sexo feminino e 43% pertencem ao sexo masculino. Ao questionar os alunos quanto ao motivo que os levou a não mais frequentar o Ensino Regular, o maior índice foi de 44,44% para ter que ajudar economicamente a família, seguido de 30,30% desistiram da escola regular devido a problemas familiares, 18,18% outros motivos, 4,04% não responderam, 2,02% foi devido à reprovação escolar, 1,01% não parou de estudar. Dos motivos que levaram os alunos entrevistados a voltar a estudar, obteve-se o maior índice a realização pessoal que ficou com 44,44%, seguido por 35,35% que pretendem adquirir um emprego, 12,12% outros motivos, 7,07% permanecer no emprego, 1,01% preferiu não responder. A partir das respostas, conclui-se que a escola CEJA SILVA FREIRE, busca atender os alunos respeitando sua cultura e história de vida.
Teachers Teaching Management During Belajar dari Rumah (BDR) Policy In Higher Education: A Piece of Teacher Sharing Ways
Authors: Latief Suryawahyuni , Hendrayani Santi , Samsuddin Samsuddin 
Published: March 2021

Teaching is an educator activity in the learning process, which aims to develop the potential that students have in the form of knowledge, skills, and attitudes. Since the Covid 19 pandemic, the government has issued a policy of "Belajar Dari Rumah" (BDR) as an effort to overcome the spread of the virus. Teaching in accordance with BDR policy makes educators at private universities in Jambi city who do not have a Learning Management System (LMS) conduct teaching management in accordance with their expertise and knowledge. This study aims to describe the experience of educators in universities who do not have LMS in managing teaching during the Covid 19 pandemic so that learning can run according to learning objectives using a qualitative descriptive approach, involving ten educators with different scientific fields and courses. This research uses a qualitative research method involving ten educators from private universities in Jambi who do not have LMS. Data have collected through observations, interviews, and documents. The data collected have analyzed through the stages of reducing data, displaying data, and drawing conclusions in accordance with research objectives. The data analyzed is using the technique validity of data through data triangulation. The study found that the management of educator teaching in private universities in Jambi city who do not have LMS is implemented BDR policies during the pandemic period following the established implementation rules without leaving the meaning of learning and learning process standards that have set out in government regulations through the stage of teaching management.
Keywords: Work from Home, Learning, Belajar dar Rumah, Teaching Management
The Transcription Factor C/EBPβ Promotes HFL-1 Cell Migration, Proliferation, and Inflammation by Activating lncRNA HAS2-AS1 in Hypoxia
Authors: Yang Xue , Qi Fei , Wei Shanchen , Lin Lianjun , Liu Xinmin 
Published: March 2021

ObjectiveRecent studies were widely concerned about the role of lncRNAs in hypoxic pulmonary hypertension (HPH). HAS2 was found significantly highly expressed in HPH, but the antisense of HAS2 (HAS2-AS1) has not been explored in HPH, providing a new potential therapeutic target of HPH.MethodsIn this study, human fetal lung fibroblast-1 (HFL-1) cells were cultured under hypoxia conditions to stimulate the pathological process of HPH. Transwell and wound-healing assays were used to detect HFL-1 cell migration, and CCK 8 assay was used to detect cell proliferation. The upstream transcription factor of HAS2-AS1 was predicted by JASPAR website, and the binding site between C/EBPβ and HAS2-AS1 was predicted by JASPAR, too. In order to verify the association between C/EBPβ and the HAS2 promoter region, we used chromatin immunoprecipitation (ChIP) and dual luciferase reporter gene detection, western blot to detect the expression of inflammation-related proteins, and qRT-PCR to detect the expression of HAS2-AS1 and HAS2. Idiopathic pulmonary fibrosis (IPF) with HPH patient microarray data was downloaded from the GEO database and analyzed by R software.ResultsOur study showed that HAS2-AS1 and C/EBPβ were highly expressed in hypoxic HFL-1 cells, and the knockdown of HAS2-AS1 expression could inhibit the proliferation, migration, and inflammatory response of HFL-1 cells. C/EBPβ binds to the promoter region of HAS2-AS1 and has a positive regulation effect on the transcription of HAS2-AS1. Furthermore, C/EBPβ can regulate the proliferation, migration, and inflammatory response of HFL-1 cells through HAS2-AS1.ConclusionThis study suggested that C/EBPβ could upregulate HAS2-AS1 expression and induce HFL-1 cell proliferation, migration, and inflammation response.
Personalised, Rational, Efficacy-Driven Cancer Drug Dosing via an Artificial Intelligence SystEm (PRECISE): A Protocol for the PRECISE CURATE.AI Pilot Clinical Trial
Authors: Tan Benjamin Kye Jyn , Teo Chong Boon , Tadeo Xavier , Peng Siyu , Soh Hazel Pei Lin , Du Sherry De Xuan , Luo Vilianty Wen Ya , Bandla Aishwarya , Sundar Raghav , Ho Dean , Kee Theodore Wonpeum , Blasiak Agata 
Published: March 2021

Introduction: Oncologists have traditionally administered the maximum tolerated doses of drugs in chemotherapy. However, these toxicity-guided doses may lead to suboptimal efficacy. CURATE.AI is an indication-agnostic, mechanism-independent and efficacy-driven personalised dosing platform that may offer a more optimal solution. While CURATE.AI has already been applied in a variety of clinical settings, there are no prior randomised controlled trials (RCTs) on CURATE.AI-guided chemotherapy dosing for solid tumours. Therefore, we aim to assess the technical and logistical feasibility of a future RCT for CURATE.AI-guided solid tumour chemotherapy dosing. We will also collect exploratory data on efficacy and toxicity, which will inform RCT power calculations.Methods and analysis: This is an open-label, single-arm, two-centre, prospective pilot clinical trial, recruiting adults with metastatic solid tumours and raised baseline tumour marker levels who are planned for palliative-intent, capecitabine-based chemotherapy. As CURATE.AI is a small data platform, it will guide drug dosing for each participant based only on their own tumour marker levels and drug doses as input data. The primary outcome is the proportion of participants in whom CURATE.AI is successfully applied to provide efficacy-driven personalised dosing, as judged based on predefined considerations. Secondary outcomes include the timeliness of dose recommendations, participant and physician adherence to CURATE.AI-recommended doses, and the proportion of clinically significant dose changes. We aim to initially enrol 10 participants from two hospitals in Singapore, perform an interim analysis, and consider either cohort expansion or an RCT. Recruitment began in August 2020. This pilot clinical trial will provide key data for a future RCT of CURATE.AI-guided personalised dosing for precision oncology.Ethics and dissemination: The National Healthcare Group (NHG) Domain Specific Review Board has granted ethical approval for this study (DSRB 2020/00334). We will distribute our findings at scientific conferences and publish them in peer-reviewed journals.Trial registration number: NCT04522284
Low Prognosis by the POSEIDON Criteria in Women Undergoing Assisted Reproductive Technology: A Multicenter and Multinational Prevalence Study of Over 13,000 Patients
Authors: Esteves Sandro C. , Yarali Hakan , Vuong Lan N. , Carvalho José F. , Özbek İrem Y. , Polat Mehtap , Le Ho L. , Pham Toan D. , Ho Tuong M. 
Published: March 2021

ObjectiveTo estimate the prevalence of low-prognosis patients according to the POSEIDON criteria using real-world data.DesignMulticenter population-based cohort study.SettingsFertility clinics in Brazil, Turkey, and Vietnam.PatientsInfertile women undergoing assisted reproductive technology using standard ovarian stimulation with exogenous gonadotropins.InterventionsNone.Main outcome measuresPer-period prevalence rates of POSEIDON patients (overall, stratified by POSEIDON groups and by study center) and the effect of covariates on the probability that a patient be classified as “POSEIDON”.ResultsA total of 13,146 patients were included. POSEIDON patients represented 43.0% (95% confidence interval [CI] 42.0–43.7) of the studied population, and the prevalence rates varied across study centers (range: 38.6–55.7%). The overall prevalence rates by POSEIDON groups were 44.2% (group 1; 95% CI 42.6–45.9), 36.1% (group 2; 95% CI 34.6–37.7), 5.2% (group 3; 95% CI 4.5–6.0), and 14.4% (group 4; 95% CI: 13.3–15.6). In general, POSEIDON patients were older, had a higher body mass index (BMI), lower ovarian reserve markers, and a higher frequency of female factor as the primary treatment indication than non-POSEIDON patients. The former required larger doses of gonadotropin for ovarian stimulation, despite achieving a 2.5 times lower number of retrieved oocytes than non-POSEIDON patients. Logistic regression analyses revealed that female age, BMI, ovarian reserve, and a female infertility factor were relevant predictors of the POSEIDON condition.ConclusionsThe estimated prevalence of POSEIDON patients in the general population undergoing ART is significant. These patients differ in clinical characteristics compared with non-POSEIDON patients. The POSEIDON condition is associated with female age, ovarian reserve, BMI, and female infertility. Efforts in terms of diagnosis, counseling, and treatment are needed to reduce the prevalence of low-prognosis patients.
Asthma-Specific Temporal Variability Reveals the Effect of Group Cognitive Behavior Therapy in Asthmatic Patients
Authors: Zhang Yuqun , Kong Youyong , Yang Yuan , Yin Yingyin , Hou Zhenghua , Xu Zhi , Yuan Yonggui 
Published: March 2021

Background: Group cognitive behavior therapy (GCBT) is a successful therapy for asthma. However, the neural biomarker of GCBT which could be used in clinic remains unclear. The temporal variability is a novel concept to characterize the dynamic functional connectivity (FC), which has many advantages as biomarker. Therefore, the aim of this study is to explore the potential difference of temporal variability between asthmatic patients and healthy controls, then determine the different patterns of temporal variability between pre- and post-treatment group and reveal the relationship between the variability and the symptoms improvement reduced by GCBT.Methods: At baseline, 40 asthmatic patients and 40 matched controls received resting-state functional magnetic resonance imaging (fMRI) scans and clinical assessments. After 8 weeks of GCBT treatment, 17 patients received fMRI scans, and assessments again. Temporal variability at baseline and post-treatment were calculated for further analysis.Results: Compared with controls, asthmatic patients showed widespread decreases in temporal variability. Moreover, the variability in both right caudate and left putamen were positively correlated with asthma control level. After GCBT, asthma control level and depression of patients were improved. Meanwhile, compared with pre-GCBT, patients after treatment showed lower variability in left opercular of Rolandic, right parahippocampal gyrus and right lingual gyrus, as well as higher variability in left temporal pole. Variability in regions which were found abnormal at baseline did not exhibit significant differences between post-GCBT and controls.Conclusions: Asthma-specific changes of dynamic functional connectivity may serve as promising underpinnings of GCBT for asthma.Clinical Trial Registration:http://www.chictr.org.cn/index.aspx, identifier: Chi-CTR-15007442.
Clinical and Electrophysiological Outcome Measures of Patients With Post-Infectious Neurological Syndromes Related to COVID-19 Treated With Intensive Neurorehabilitation
Authors: Avenali Micol , Martinelli Daniele , Todisco Massimiliano , Canavero Isabella , Valentino Francesca , Micieli Giuseppe , Alfonsi Enrico , Tassorelli Cristina , Cosentino Giuseppe 
Published: March 2021

Background: The clinical spectrum of coronavirus disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be quite wide, including neurological symptoms. Among them, para-infectious or post-infectious neurological syndromes (PINS), caused by an inflammatory response against the central and/or peripheral nervous system, have been reported. The aim of this paper is to illustrate the functional and neurophysiological recovery in a series of subjects with COVID-19-related PINS who underwent intensive neurorehabilitation.Materials and Methods: Five patients with PINS associated with COVID-19 were evaluated at baseline and followed up for 6 months. Three of them had polyradiculoneuropathy and two patients had myelitis. The onset of the neurological syndromes was temporally associated with the SARS-CoV-2 infection. After completing the acute neurological treatments in the intensive care unit, patients underwent a personalized multidisciplinary rehabilitation program. An in-depth clinical, functional, and electrophysiological assessment was carried out at baseline and at 3- and 6-month follow-ups.Results: Among patients with polyradiculoneuropathy, the electrophysiological evaluation at baseline disclosed an acute inflammatory demyelinating polyradiculoneuropathy (AIDP) in two patients and an acute motor and sensory axonal neuropathy (AMSAN) in the third patient. At follow-up, the electrophysiological features improved in one subject with AIDP and were stable in the remaining two cases. The functional assessment after neurorehabilitation showed global recovery and full independence in walking and in activities of daily life in one patient and mild improvement in the other two cases. Of the two subjects with myelitis, the baseline electrophysiological examination showed a prolonged central motor conduction time, which returned to normal in one patient, whereas it improved but remained pathological in the other patient at follow-up. The neurorehabilitation led to a substantial functional improvement in both subjects.Discussion and Conclusions: This is the first study to describe clinical and electrophysiological aspects along with medium-term outcome in patients with COVID-19-related neurological manifestations who underwent an intensive rehabilitation program. The functional outcome following neurorehabilitation in patients with PINS related to SARS-CoV-2 infection is variable. In our small case series, subjects with polyradiculoneuropathy had a poorer recovery compared to patients with myelitis. The clinical course largely paralleled the follow-up electrophysiological findings.