bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interplay of Malm carbonate permeability, gravity-driven groundwater flow, and paleoclimate – implications for the geothermal field and potential in the Molasse Basin (southern Germany), a foreland-basin play
Authors: Schintgen Tom Vincent , Moeck Inga Sigrun 
Published: October 2021

AbstractThe Molasse Basin in Southern Germany is part of the North Alpine Foreland Basin and hosts the largest accumulation of deep geothermal production fields in Central Europe. Despite the vast development of geothermal energy utilization projects especially in the Munich metropolitan region, the evolution of and control factors on the natural geothermal field, more specifically the time-varying recharge and discharge governing groundwater and heat flow, are still debated. Within the Upper Jurassic (Malm) carbonate aquifer as the main geothermal reservoir in the Molasse Basin, temperature anomalies such as the Wasserburg Trough anomaly to the east of Munich and their underlying fluid and heat transport processes are yet poorly understood. We delineate the two end members of thermal–hydraulic regimes in the Molasse Basin by calculating two contrasting permeability scenarios of the heterogeneously karstified Malm carbonate aquifer along a model section through the Wasserburg Trough anomaly by means of two-dimensional numerical thermal-hydraulic modelling. We test the sensitivity of the thermal-hydraulic regime with regard to paleoclimate by computing the two Malm permeability scenarios both with a constant surface temperature of 9 °C and with the impact of paleo-temperature changes during the last 130 ka including the Würm Glaciation. Accordingly, we consider the hydraulic and thermal effects of periglacial conditions like permafrost formation and the impact of the numerous glacial advances onto the Molasse Basin. Thermal-hydraulic modelling reveals the effect of recurrent glacial periods on the subsurface targets of geothermal interest, which is minor compared to the effect of permeability-related, continuous gravity-driven groundwater flow as a major heat transport mechanism.
A comparison of the Food and Drug Administration’s and Health Canada’s regulatory decisions about failed confirmatory trials for oncology drugs: an observational study
Authors: Lexchin Joel 
Published: October 2021

Abstract
Background
Oncology drugs are frequently approved on the basis of surrogate outcomes that require further trials to confirm the benefits, but at times these trials fail and regulators need to decide whether to withdraw approval for the indication and/or to remove the drug from the market. This study compares decisions by the Food and Drug Administration and Health Canada about oncology drugs that were approved using either Accelerated Approval (FDA) or Notice of Compliance with conditions (NOC/c, Health Canada) and that failed confirmatory trials.

Methods
Drug/indications approved by the FDA through its Accelerated Approval Pathway and that later failed confirmatory studies were identified from a published study and additional information on these drugs was collected from Drugs@FDA. Health Canada websites were searched on September 11, 2021 for the same group of drugs to determine if they were approved in Canada under the NOC/c pathway for the same indication as in the US. Information from both the FDA and Health Canada about these products was entered into an Excel spreadsheet. Decisions about whether to withdraw the drugs or remove the failed indication for the drug and requirements for confirmatory studies were compared. In addition, the dates of decisions by the two agencies were compared.

Results
Ten drug/indications were available for comparison. Regulatory decisions were similar in 4 cases, different in 1 case and could not be determined in the remaining 5, in 1 case because decisions were pending in both countries and in the other 4, because the NOC/c had not been fulfilled in Canada. The requirements for the confirmatory studies were similar in both countries. Decisions were made earlier in the United States.

Conclusions
This study shows that decisions made by Health Canada and the FDA about whether to withdraw a drug or remove a failed indication when drug/indications fail a confirmatory trial are usually similar, although the sample size on which this conclusion is made is small. The clinical implications of these similarities and differences should be explored.
Analysis of the regional distribution of road traffic mortality and associated factors in Japan
Authors: Okui Tasuku , Park Jinsang 
Published: October 2021

Abstract
Background
Regional differences in road traffic (RT) mortality among municipalities have not been revealed in Japan. Further, the association between RT mortality and regional socioeconomic characteristics has not been investigated. We analyzed geographic differences in RT mortality and its associated factors using the Vital Statistics in Japan.

Methods
We used data on RT mortality by sex and municipality in Japan from 2013 to 2017. We calculated the standardized mortality ratio (SMR) of RT for each municipality by sex using an Empirical Bayes method. The SMRs were mapped onto a map of Japan to show the geographic differences. In addition, an ecological study investigated the municipal characteristics associated with the SMR using demographic socioeconomic, medical, weather, and vehicular characteristics as explanatory variables. The ecological study used a spatial statistical model.

Results
The mapping revealed that the number of municipalities with a high SMR of RT (SMR > 2) was larger in men than in women. In addition, SMRs of capital areas (Kanagawa and Tokyo prefectures) tended to be low in men and women. The regression analysis revealed that population density was negatively associated with the SMR in men and women, and the degree of the association was the largest among explanatory variables. In contrast, there was a positive association between the proportion of non-Japanese persons and SMR. The proportions of lower educational level (elementary school or junior high school graduates), agriculture, forestry, and fisheries workers, service workers, and blue-collar workers were positively associated with the SMR in men. The proportion of unemployed persons was negatively associated with the SMR in men.

Conclusions
Socioeconomic characteristics are associated with geographic differences in RT mortality particularly in men. The results suggested preventive measures targeted at men of low socioeconomic status and non-Japanese persons are needed to decrease RT mortality further.
Forensic investigation of flowslides triggered by the 2018 Sulawesi earthquake
Authors: Rohit Divyesh , Hazarika Hemanta , Maeda Tsubasa , Sumartini Wa Ode , Kokusho Takaji , Manafi Khajeh Pasha Siavash , Nurdin Sukiman 
Published: October 2021

AbstractThe Sulawesi earthquake with a moment magnitude of Mw 7.5 struck the Central Sulawesi region of the Sulawesi Island, Indonesia, on September 28, 2018. The epicenter of the earthquake was located in the mountainous region of Donggala Regency, in the neck of the Minahasa Peninsula in the Central Sulawesi Province of Indonesia. Although the epicenter was located in Donggala Regency, the greatest devastating effects were observed about 70 km south of the epicenter in the Palu Valley. The event was the first of its kind to cause large-scale flowslides simultaneously at four key locations such as Balaroa, Petobo, Jono Oge, and Sibalaya with extensive ground displacements ranging from several hundred meters to more than 1 km. This article reviews the field observations of geotechnical failures and infrastructure damage caused by liquefaction resulting from the shallow strike-slip earthquake at Palu City, Donggala Regency, and Sigi Regency. A geo-spatial analysis was performed on data collected from aerial drone imagery, along with portable dynamic cone penetration testing (PDCPT) in the field. The investigation revealed a highly stratified ground with alternating soil layers of varying permeability and very low bearing resistance at shallow depths. The investigation also helped in assessing the extent of damage caused by geotechnical failure to the residential infrastructures, irrigation structures, and roads.
Graphical Abstract
Endocrine response of early-hatching Asian Short-toed Lark nestlings exposed to cold temperature in a high-latitude grassland habitat
Authors: Shang Jing , Zhang Liang , Li Xinyu , Zhang Shuping 
Published: October 2021

AbstractBackgroundIn high latitude grassland habitats, altricial nestlings hatching in open-cup nests early in the breeding season must cope with cold temperature challenges. Thyroid hormones (triiodothyronine, T3and thyroxine, T4) and corticosterone play a crucial role in avian thermoregulation response to cold. Investigating the endocrine response of altricial nestlings to temperature variation is important for understanding the adaptive mechanisms of individual variation in the timing of breeding in birds.MethodsWe compared nest temperature, ambient temperature, body temperature, plasma T3, T4and corticosterone levels in Asian Short-toed Lark (Alaudala cheleensis) nestlings hatching in the early-, middle-, and late-stages of the breeding season in Hulunbuir grassland, northeast China.ResultsMean nest temperature in the early-, middle- and late-stage groups was − 1.85, 3.81 and 10.23 °C, respectively, for the 3-day-old nestlings, and 6.83, 10.41 and 11.81 °C, respectively, for the 6-day-old nestlings. The nest temperature significantly correlated with body temperature, plasma T3, T4and corticosterone concentrations of nestlings. Body temperature of 3-day-old nestlings in the early and middle groups was significantly lower than that of the late group, but there was no significant difference between the nestlings in the early and middle groups. The T4and T3concentrations and the ratio of T3/T4of both 3- and 6-day-old nestlings in the early-stage group were significantly higher compared to the middle and late groups. The corticosterone levels of 3-day-old nestlings were significantly higher in the early-stage group compared to the middle- and late-stage groups.ConclusionNestlings hatching early responded to cold temperature by increasing thyroid hormones and corticosterone levels even in the early days of post hatching development when the endothermy has not been established. These hormones may play a physiological role in neonatal nestlings coping with cold temperature challenges.
Outcomes of multiple gestation births compared to singleton: analysis of multicenter KID database
Authors: Kalikkot Thekkeveedu Renjithkumar , Dankhara Nilesh , Desai Jagdish , Klar Angelle L. , Patel Jaimin 
Published: October 2021

Abstract
Background
The available data regarding morbidity and mortality associated with multiple gestation births is conflicting and contradicting.

Objective
To compare morbidity, mortality, and length of stay (LOS) outcomes between multiple gestation (twin, triplet and higher-order) and singleton births.

Methods
Data from the national multicenter Kids’ Inpatient Database of the Healthcare Cost and Utilization Project from the years 2000, 2003, 2006, 2009, 2012, and 2016 were analyzed using a complex survey design using Statistical Analysis System (SAS) 9.4 (SAS Institute, Cary NC). Neonates with ICD9 and ICD10 codes indicating singletons, twins or triplets, and higher-order multiples were included. Mortality was compared between these groups after excluding transfer outs to avoid duplicate inclusion. To analyze LOS, we included inborn neonates and excluded transfers; who died inpatient and any neonates who appear to have been discharged less than 33 weeks PMA. The LOS was compared by gestational age groups.

Results
A total of 22,853,125 neonates were analyzed for mortality after applying inclusion-exclusion criteria; 2.96% were twins, and 0.13% were triplets or more. A total of 22,690,082 neonates were analyzed for LOS. Mean GA, expressed as mean (SD), for singleton, twins and triplets, were 38.30 (2.21), 36.39 (4.21), and 32.72 (4.14), respectively. The adjusted odds for mortality were similar for twin births compared to singleton (aOR: 1.004, 95% CI:0.960–1.051, p = 0.8521). The adjusted odds of mortality for triplet or higher-order gestation births were higher (aOR: 1.33, 95% CI: 1.128–1.575, p = 0.0008) when compared to the singleton births. Median LOS (days) was significantly longer in multiple gestation compared to singleton births overall (singletons: 1.59 [1.13, 2.19] vs. twins 3.29 [2.17, 9.59] vs. triplets or higher-order multiples 19.15 [8.80, 36.38], p < .0001), and this difference remained significant within each GA category.

Conclusion
Multiple gestation births have higher mortality and longer LOS when compared to singleton births. This population data from multiple centers across the country could be useful in counseling parents when caring for multiple gestation pregnancies.
Maternal minimum dietary diversity and associated factors among pregnant women, Southwest Ethiopia, 2021
Authors: Tilahun Abel Girma , Kebede Abebaw Molla 
Published: October 2021

AbstractBackgroundInadequate dietary diversity intake during pregnancy increases risks of intrauterine growth restriction, abortion, low birth weight, preterm birth, prenatal and infant mortality,and morbidity and has long-lasting health impacts. Dietary diversity during pregnancy promotes the health status of the mother and her fetus. This study aimed to assess the magnitude of minimum dietary diversity and associated factors among pregnant women attending antenatal care.MethodsA facility-based cross-sectional study was conducted among 274 pregnant women who attended antenatal care at Wacha primary hospital from January to February 2021. A systematic sampling method was used to select the study participants. The data were collected through face-to-face interviews using a structured and semi-structured questionnaire. Bivariate logistic regression was done to identify factors associated with maternal dietary diversity. Finally, multivariate logistic regression was done, and variables that showedPvalues of < 0.05 were considered statistically significant.ResultThe magnitude of minimum dietary diversity was 51% (95% CI: 44.5, 56.7). The mean (±SD) minimum dietary diversity score was 4.5 (± 1.268) with a minimum of 1 anda maximum of 8 food groups consumed out of ten food groups. Age fewer than 25 years (AOR 4.649; 95% CI; 1.404, 15.396), and the age group between 25 to 34 years (AOR 3.624; 95% CI: 1.315, 10.269), husband age group of 26 to 34 years (AOR 2.238; 95% CI; 1.028,4.873), and 35 to 44 years (AOR 3.555; 95% CI; 1.228,10.292) and nutrition awareness of women (AOR 2.182; 95% CI; 1.243, 3.829) were significantly associated with minimum dietary diversity.ConclusionThe consumption of minimum dietary diversity of the pregnant mothers was found to be low. Women aged less than 25 and age between 25 to 34 years, husband’s age between 26 to 34 and 35 to 44 years, and nutrition awareness were the factors significantly associated with minimum dietary diversity. Therefore, providing nutrition education and counseling service warranted to promote maternal dietary diversity.
Feasibility study to assess the delivery of a novel isometric exercise intervention for people with stage 1 hypertension in the NHS: protocol for the IsoFIT-BP study including amendments to mitigate the risk of COVID-19
Authors: Wiles Jonathan , Rees-Roberts Melanie , O’Driscoll Jamie M. , Doulton Timothy , MacInnes Douglas , Short Vanessa , Pellatt-Higgins Tracy , Saxby Katie , Gousia Katerina , West Alan , Smith Maggie , Santer Ellie , Darby John , Farmer Chris K. 
Published: October 2021

Abstract
Background
Hypertension (HTN) affects approximately 25% of the UK population and is a leading cause of mortality. Associated annual health care costs run into billions. National treatment guidance includes initial lifestyle advice, followed by anti-hypertensive medication if blood pressure (BP) remains high. However, adoption and adherence to recommended exercise guidelines, dietary advice and anti-hypertensive medication is poor. Four short bouts of isometric exercise (IE) performed 3 days per week (d/wk) at home elicits clinically significant reductions in BP in those with normal to high-normal BP. This study will determine the feasibility of delivering personalised IE to patients with stage 1 hypertension for whom lifestyle changes would be recommended before medication within NHS primary care.

Methods
This is a randomised controlled feasibility study. Participants were 18+ years, with stage 1 hypertension, not on anti-hypertensive medication and without significant medical contraindications. Trial arms will be standard lifestyle advice (control) or isometric wall squat exercise and standard lifestyle advice. Primary outcomes include the feasibility of healthcare professionals to deliver isometric exercise prescriptions in a primary care NHS setting and estimation of the variance of change in systolic BP. Secondary outcomes include accuracy of protocol delivery, execution of and adherence to protocol, recruitment rate, attrition, perception of intervention viability, cost, participant experience and accuracy of home BP. The study will last 18 months. Sample size of 100 participants (50 per arm) allows for 20% attrition and 6.5% incomplete data, based upon 74 (37 each arm) participants (two-sided 95% confidence interval, width of 1.33 and standard deviation of 4) completing 4 weeks. Ethical approval IRAS ID is 274676.

Discussion
Before the efficacy of this novel intervention to treat stage 1 hypertension can be investigated in any large randomised controlled trial, it is necessary to ascertain if it can be delivered and carried out in a NHS primary care setting. Findings could support IE viability as a prophylactic/alternative treatment option.

Trial registration
ISRCTN13472393, registered 18 August 2020
Burden of mental health symptoms and perceptions of their management in in-centre hemodialysis care: a mixed methods study
Authors: Schick-Makaroff Kara , Wozniak Lisa A. , Short Hilary , Davison Sara N. , Klarenbach Scott , Buzinski Robert , Walsh Michael , Johnson Jeffrey A. 
Published: October 2021

Abstract
Background
We aimed to describe (1) depressive and anxiety symptom burdens reported by adults on in-centre hemodialysis in Northern Alberta, Canada and (2) patients’ and nurses’ perceptions of managing such symptoms using routine patient-reported outcome measures (PROMs).

Methods
A longitudinal mixed methods approach was employed. Cluster randomized controlled trial data exposed the prevalence of positive screens (scores ≥ 3) for depressive (PHQ-2) and anxiety (GAD-2) symptoms. A descriptive qualitative approach was used to understand patients’ and nurses’ perceptions of managing these symptoms using the ESAS-r: Renal and EQ-5D-5L. Using purposeful sampling, patients and nurses were invited for interviews. Field notes were documented from 6 dialysis unit observations. Patients’ responses to open-ended survey questions and nurses’ electronic chart notes related to mental health were compiled. Thematic and content analyses were used.

Results
Average age of patients (n = 408) was 64.0 years (SD 15.4), 57% were male, and 87% were not working; 29% screened positive for depressive symptoms, 21% for anxiety symptoms, and 16% for both. From patient (n = 10) and nurse (n = 8) interviews, unit observations, patient survey responses (n = 779) and nurses’ chart notes (n = 84), we discerned that PROMs (ESAS-r: Renal/EQ-5D-5L) had the potential to identify and prompt management of mental health concerns. However, opinions differed about whether mental health was within kidney care scope. Nonetheless, participants agreed there was a lack of mental health resources.

Conclusions
Prevalence of depressive and anxiety symptoms aligned with existing literature. Tensions regarding mental health management highlight the need for systemic decisions about how routine PROM use, including mental health assessment, may be optimized to meet patients’ needs.
Biocontrol potential of entomopathogenic fungi, nematodes and bacteria against Rhynchophorus ferrugineus (Olivier)
Authors: Yasin Muhammad , Wakil Waqas , Qayyum Mirza Abdul , Ali Sajjad , Sajjad Asif , Aqueel Muhammad Anjum , Shakeel Muhammad 
Published: October 2021

Abstract
Background
The red palm weevil (RPW), Rhynchophorus ferrugineus (Olivier) (Coleoptera: Curculionidae), is a serious threat to date palms across the globe, causing heavy yield losses. The pest inflicts damage to palms stem and destroys vascular system; resultantly lower the vigor and affect the growth and yield. For ecological farming system, biological control of the pest is gaining increased interest due to hosts’ specificity, safety to human, animal and non-target organisms, and their compatibility to environment.

Results
In laboratory assay, Beauveria bassiana, Heterorhabditis bacteriophora and Bacillus thuringiensis var. kurstaki (Bt-k) alone and in combination against sixth instar larvae and adults of four distinct populations of RPW were applied. H. bacteriophora was more effective, followed by B. bassiana and Bt-k in alone treatments. While in combined treatments, the highest mortality was recorded for H. bacteriophora + B. bassiana combination (100% for both stages), followed by H. bacteriophora + Bt-k, (larvae 100%; adults 94.24%) and B. bassiana + Bt-k treatments (larvae: 87.01%; adults: 80.53%). Maximum rate of mycosis (larvae 85.74%; adults 69.07%), sporulation (larvae 189.22 conidia ml−1; adults 164.56 conidia ml−1), cadavers affected by nematodes (larvae 92.4%; adults 81.29%) and nematode production (larvae 178.78 IJs ml−1; adults 153.44 IJs ml−1) was observed where B. bassiana or H. bacteriophora was applied alone and the lowest (larvae 122.78 IJs ml−1; adults: 103.22 IJs ml−1) was recorded for H. bacteriophora + B. bassiana combination.

Conclusions
Entomopathogens can be effectively used alone and/or in integration to control RPW populations. Natural capability of entomopathogens to infect and disseminate into other hosts makes them excellent biocontrol agents to be incorporated in the IPM plan of RPW and to make palm growers confident with the use of the most promising microbial control agents.