bluuebunny/crossref_metadata_2025_split huggingface dataset:
Farm to farm wake interaction in WRF: impact on power production
Authors: Mayol ML , Saulo AC , Otero AD 
Published: June 2021

Abstract
This work focuses on the study of interactions between neighboring wind farms through a mesoscale numerical modelling approach. High resolution simulations with three wind farm parameterizations (WFP, EWP and IAWFP), implemented on the WRF model, over a set of “real world” neighboring onshore wind farms are performed. The sensitivity of the three parameterizations to wake development is analyzed. The older version of the WFP is also included to account for differences between versions in terms of wake length and intensity, and TKE production and advection. Finally, the impacts of upstream wind farms are studied through a series of simulations where they are “disabled” and the increases in power at downstream farms are quantified. These results and the adopted methodology have direct application and are highly relevant for the feasibility assessment of new wind farms in the shadow of other existing ones.
Production and Cost Assessment of Offshore Wind Power in the North Sea
Authors: Sørensen J N , Larsen G C , Cazin-Bourguignon A 
Published: June 2021

Abstract
A minimalistic model complex for determining the available wind power and associated costs related to the development of large–scale offshore wind power was recently developed by Sørensen and Larsen [1]. The model complex demands only a few global input parameters, such as turbine rotor diameter, nameplate capacity, area of wind farm, number of turbines, water depth, and mean wind speed Weibull parameters for the site. Using actual wind climate and bathymetric data for the North Sea, the model is in the present work used to map the annual energy production and levelized cost of energy (LCoE) for wind farms located in the North Sea. As a main conclusion, exploiting all locations with water depths down to about 45 m comply with the electrical power demand of Europe, which is about 3500 TWh/year. In this case, the LCoE is found to be about 7 ∈cents/kWh for wind farms consisting of 15 MW wind turbines and an interspacing between the wind turbines of 8 diameter, corresponding to 2 km.
Exploring the application of reinforcement learning to wind farm control
Authors: Korb Henry , Asmuth Henrik , Stender Merten , Ivanell Stefan 
Published: June 2021

Abstract
Optimal control of wind farms to maximize power is a challenging task since the wake interaction between the turbines is a highly nonlinear phenomenon. In recent years the field of Reinforcement Learning has made great contributions to nonlinear control problems and has been successfully applied to control and optimization in 2D laminar flows. In this work, Reinforcement Learning is applied to wind farm control for the first time to the authors’ best knowledge. To demonstrate the optimization abilities of the newly developed framework, parameters of an already existing control strategy, the helix approach, are tuned to optimize the total power production of a small wind farm. This also includes an extension of the helix approach to multiple turbines. Furthermore, it is attempted to develop novel control strategies based on the control of the generator torque. The results are analysed and difficulties in the setup in regards to Reinforcement Learning are discussed. The tuned helix approach yields a total power increase of 6.8% on average for the investigated case, while the generator torque controller does not yield an increase in total power. Finally, an alternative setup is proposed to improve the design of the problem.
Tool changing 3D printer for rapid prototyping of advanced soft robotic elements
Authors: Conrad Stefan , Speck Thomas , Tauber Falk J 
Published: June 2021

Abstract
In the field of soft robotics, pneumatic elements play an important role due to their sensitive and adaptive behavior. Nevertheless, the rapid prototyping of such actuators is still challenging since conventional 3D printers are not designed to fabricate airtight objects or to specify their bending behavior by combining materials of different stiffness. In order to address this challenge, a tool changing multi-material 3D printer has been constructed, which can be equipped with various print-heads fitted to the specific application. By alternately processing filaments with varying mechanical properties, a series of pneumatic elements was produced. The actuators were printed in thermoplastic polyurethane with shore hardness A70 for flexible parts and D65 for stiff parts. A novel procedure for the feature adaptation of the flow rate allowed the fabrication of vertically printed flexible membranes with a thickness of just 500 μm. This way the bending and expanding printed structures can all be actuated with a pressure of 100 kPa or less. Furthermore, a new kind of generic actuator that is customizable to specific tasks and can perform complex motion behavior was designed. All together, these actuators demonstrate the high potential of the developed platform for further research on and production of soft robotic elements and complex pressurized systems.
Light absorption enhancement and radiation hardening for triple junction solar cell through bioinspired nanostructures
Authors: Vasileiou Thomas , Llorens José M , Buencuerpo Jerónimo , Ripalda José M , Izzo Dario , Summerer Leopold 
Published: June 2021

Abstract
Multi-junction solar cells constitute the main source of power for space applications. However, exposure of solar cells to the space radiation environment significantly degrades their performance across the mission lifetime. Here, we seek to improve the radiation hardness of the triple junction solar cell, GaInP/Ga(In)As/Ge, by decreasing the thickness of the more sensitive middle junction. Thin junctions facilitate the collection of minority carriers and show slower degradation due to defects. However, thinning the junction decreases the absorption, and consequently, the expected photocurrent. To compensate for this loss, we examined two bioinspired surface patterns that exhibit anti-reflective and light-trapping properties: (a) the moth-eye structure which enables vision in poorly illuminated environments and (b) the patterns of the hard cell of a unicellular photosynthetic micro-alga, the diatoms. We parametrize and optimize the biomimetic structures, aiming to maximize the absorbed light by the solar cell while achieving significant reduction in the middle junction thickness. The density of the radiation-induced defects is independent of the junction thickness, as we demonstrate using Monte Carlo simulations, allowing the direct comparison of different combinations of middle junction thicknesses and light trapping structures. We incorporate the radiation effects into the solar cell model as a decrease in minority carrier lifetime and an increase in surface recombination velocity, and we quantify the gain in efficiency for different combinations of junction thickness and the light-trapping structure at equal radiation damage. Solar cells with thin junctions compensated by the light-trapping structures offer a promising approach to improve solar cell radiation hardness and robustness, with up to 2% higher end-of-life efficiency than the commonly used configuration at high radiation exposure.
Relation between micro- and nanostructure features and biological properties of the decellularized rat liver
Authors: Bobrova Maria M , Safonova Liubov A , Efimov Anton E , Iljinsky Igor M , Agapova Olga I , Agapov Igor I 
Published: June 2021

AbstractOrgan decellularization is one of the promising technologies of regenerative medicine, which allows obtaining cell-free extracellular matrix (ECM), which provide preservation of the composition, architecture, vascular network and biological activity of the ECM. The method of decellularization opens up wide prospects for its practical application not only in the field of creating full-scale bioengineered structures, but also in the manufacture of vessels, microcarriers, hydrogels, and coatings. The main goal of our work was the investigation of structure and biological properties of lyophilized decellularized Wistar rat liver fragments (LDLFs), as well as we assessed the regenerative potential of the obtained ECM. We obtained decellularized liver of a Wistar rat, the vascular network and the main components of the ECM of tissue were preserved. H&E staining of histological sections confirmed the removal of cells. DNA content of ECM is equal to 0.7% of native tissue DNA content. Utilizing scanning probe nanotomogrphy method, we showed sinuous, rough topography and highly nanoporous structure of ECM, which provide high level of mouse 3T3 fibroblast and Hep-G2cells biocompatibility. Obtained LDLF had a high regenerative potential, which we studied in an experimental model of a full-thickness rat skin wound healing: we observed the acceleration of wound healing by 2.2 times in comparison with the control.
Informing the planning of rotating power outages in heat waves through data analytics of connected smart thermostats for residential buildings
Authors: Wang Zhe , Hong Tianzhen , Li Han 
Published: June 2021

Abstract
With climate change, heat waves have become more frequent and intense. Rotating power outages happen when the power supply is unable to meet the cooling demand increase resulting from extreme high temperatures. Power outages during heat waves expose residents to high risks of overheating. In this study, we propose a novel data-driven inverse modelling approach to inform decision makers and grid operators on planning rotating power outages. We first infer the building thermal characteristics using the connected smart thermostat data, and used the estimated thermal dynamics to simulate the thermal resilience during a heat wave event. Our proposed method was tested for the California power outage in August 2020 by using the open source Ecobee Donate Your Data dataset. We found in California the power outage should not last more than two hours during heat waves to avoid overheating risks. Informing the residents in advance so they can prepare for it through pre-cooling is a simple but effective strategy to expand the acceptable power outage duration. In addition to assisting power outage planning, the proposed method can be used for other applications, such as to evaluate a building energy efficiency policy, to examine fuel poverty, and to estimate the load shifting potential of building stocks.
Computational design of ultrashort peptide inhibitors of the receptor-binding domain of the SARS-CoV-2 S protein
Authors: Pei Pengfei , Qin Hongbo , Chen Jialin , Wang Fengli , He Chengzhi , He Shiting , Hong Bixia , Liu Ke , Qiao Renzhong , Fan Huahao , Tong Yigang , Chen Long , Luo Shi-Zhong 
Published: June 2021

Abstract
Targeting the interaction between severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)-receptor-binding domain (RBD) and angiotensin-converting enzyme 2 (ACE2) is believed to be an effective strategy for drug design to inhibit the infection of SARS-CoV-2. Herein, several ultrashort peptidase inhibitors against the RBD–ACE2 interaction were obtained by a computer-aided approach based on the RBD-binding residues on the protease domain (PD) of ACE2. The designed peptides were tested on a model coronavirus GX_P2V, which has 92.2 and 86% amino acid identity to the SARS-CoV-2 spike protein and RBD, respectively. Molecular dynamics simulations and binding free energy analysis predicted a potential binding pocket on the RBD of the spike protein, and this was confirmed by the specifically designed peptides SI5α and SI5α-b. They have only seven residues, showing potent antiviral activity and low cytotoxicity. Enzyme-linked immunosorbent assay result also confirmed their inhibitory ability against the RBD–ACE2 interaction. The ultrashort peptides are promising precursor molecules for the drug development of Corona Virus Disease 2019, and the novel binding pocket on the RBD may be helpful for the design of RBD inhibitors or antibodies against SARS-CoV-2.
Social Work Practitioners and Human Service Professionals in the 2016 Alberta (Canada) Wildfires: Roles and Contributions
Authors: Drolet Julie L , Lewin Bonnie , Pinches Alison 
Published: June 2021

AbstractThe 2016 Alberta wildfires resulted in devastating human, economic and environmental impacts. Social work practitioners and human service professionals are increasingly involved in disaster contexts yet there remains a pressing need to better understand their professional role and contributions. The wildfire resulted in the mobilisation and engagement of social work practitioners and human service professionals to meet the needs of individuals, families, groups and affected community members. Research was undertaken to identify the roles and responsibilities of social work practitioners and human service professionals in the context of the wildfires in Fort McMurray, AB, Canada. Forty social work practitioners and human service professionals were interviewed about their direct experience in the provision of social services in the context of the 2016 wildfire. This article shares the findings based on four themes: social work practice in disaster contexts; social work role in disaster management; building capacity and advocacy, wellness and self-care. Implications and recommendations discuss the need to enhance understandings of the roles and contributions of social work practitioners and human service professionals in disasters with a particular focus on long-term disaster recovery.
CDC42EP3 is a key promoter involved in the development and progression of gastric cancer
Authors: Chen Wenchao , Zhu Yuanzeng , Zhang Wei , Zhang Han , Zhou Yang , Sun Peichun , Wu Gang 
Published: June 2021

AbstractGastric cancer (GC) is one of the most prevalent cancers and severely endangers human health. Due to the low rate of diagnosis, most patients with GC are diagnosed as advanced. CDC42 effector protein 3 (CDC42EP3) has been revealed to be involved in several types of human cancers’ development and progression. However, the function of CDC42EP3 in GC is not yet clear. CDC42EP3 expression was detected by immunohistochemistry, quantitative real-time PCR and Western blot assay in tumor tissues and cell lines of GC. CDC42EP3 knockdown cell models were constructed by lentivirus transfection. Cell proliferation was evaluated by the 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The wound-healing assay and the transwell assay were utilized to assess the cell migration. Also, the cell apoptosis and the cell cycle were evaluated by flow cytometry. Moreover, the mechanism was investigated by Human Apoptosis Antibody Array. The in vivo experiments were conducted to verify the effects of CDC42EP3 knockdown on the tumor growth of GC. The expression level of CDC42EP3 was up-regulated in tumor tissues. High CDC42EP3 expression was positively related to more advanced tumor grade. CDC42EP3 knockdown inhibited cell proliferation and migration, promoted cell apoptosis and suppressed the tumor growth. On the other hand, it was also found that the silencing of CDC42EP3 inhibited HSP27 and IGF-1sR expression as well as promoted Caspase3, p53, TNF-α, TNF-β, TRAILR-1 and TRAILR-2 expression. CDC42EP3 was revealed to work as a tumor promoter in the development and progression of GC, which could be a promising therapeutic target for the therapy of GC.
Confessional Approach to Disclosure of Medical Error
Authors: Mason Jordan 
Published: June 2021

Abstract
Recent literature on the ethics of medical error disclosure acknowledges the feelings of injustice, confusion, and grief patients and their families experience as a result of medical error. Substantially less literature acknowledges the emotional and relational discomfort of the physicians responsible or suggests a meaningful way forward. To address these concerns more fully, I propose a model of medical error disclosure that mirrors the theological and sacramental technique of confession. I use Aquinas’ description of moral acts to show that all medical errors are evil, and some accidental medical errors constitute venial sins; all sin and evil should be confessed. As Aquinas urges confession for sins, here I argue that confession is necessary to restore physicians to the community and to provide a sense of absolution. Even mistakes for which physicians are not morally culpable ought to be confessed in order to heal the physician–patient relationship and to address feelings of professional distress. This paper utilizes an Episcopal theology of confession that affirms verbal admission and responsibility-taking as freeing and relationally restoring acts, arguing that a confessional stance toward medical error both leads to better outcomes in physician–patient relationships and is more compassionate toward physicians who err.
Alteration in Urease-producing Bacteria in the Gut Microbiomes of Patients with Inflammatory Bowel Diseases
Authors: Ryvchin Ron , Dubinsky Vadim , Rabinowitz Keren , Wasserberg Nir , Dotan Iris , Gophna Uri 
Published: June 2021

AbstractBackground and AimsBacterial urease is a major virulence factor of human pathogens, and murine models have shown that it can contribute to the pathogenesis of inflammatory bowel diseases [IBD].MethodsThe distribution of urease-producing bacteria in IBD was assessed using public faecal metagenomic data from various cohorts, including non-IBD controls [n = 55], patients with Crohn’s disease [n = 291] or ulcerative colitis [n = 214], and patients with a pouch [n = 53]. The ureA gene and the taxonomic markers gyrA, rpoB, and recA were used to estimate the percentage of urease producers in each sample.ResultsLevels of urease producers in patients with IBD and non-IBD controls were comparable. In non-IBD controls and most IBD patients, urease producers were primarily acetate-producing genera such as Blautia and Ruminococcus. A shift in the type of the dominant urease producers towards Proteobacteria and Bacilli was observed in a subset of all IBD subtypes, which correlated with faecal calprotectin levels in one cohort. Some patients with IBD had no detectable urease producers. In patients with a pouch, the probiotic-associated species Streptococcus thermophilus was more common as a main urease producer than in other IBD phenotypes, and it generally did not co-occur with other Bacilli or with Proteobacteria.ConclusionsUnlike all non-IBD controls, patients with IBD often showed a shift towards Bacilli or Proteobacteria or a complete loss of urease production. Probiotics containing the species S. thermophilus may have a protective effect against colonisation by undesirable urease-producing bacteria in a subset of patients with a pouch.
Does External Monitoring from the Government Improve the Performance of State-Owned Enterprises?
Authors: Li Shengyu , Zhang Hongsong 
Published: June 2021

Abstract
In this paper we investigate the impact of external monitoring from the government on state-owned enterprise performance, using the variation in monitoring strength arising from a nationwide policy change and firms’ geographic location in China. We utilise a structural approach to estimate input prices and productivity separately at the firm level using commonly available production data. We show that enhanced external monitoring, as a key component of corporate governance, can substantially reduce managerial expropriation in procurement (proxied by input prices) and shirking in production management (proxied by productivity). The results suggest that government monitoring can be an effective policy instrument to improve state-owned enterprise performance.
Near-Infrared Spectroscopy for Discrimination of Charcoal from Eucalyptus and Native Cerrado Species—Contribution to a Database for Forestry Supervision
Authors: Nisgoski Silvana , Gonçalves Thaís A P , Sonsin-Oliveira Júlia , Ballarin Adriano W , Muñiz Graciela I B 
Published: June 2021

Abstract
The illegal charcoal trade is an internationally well-known forest crime. In Brazil, government agents try to control it using the document of forest origin (DOF). To confirm a load’s legality, the agents must compare it with the declared content of the DOF. However, to identify charcoal is difficult even for specialists in wood anatomy. Hence, new technologies would facilitate the agents’ work. Near-infrared spectroscopy (NIR) provides a rapid and precise response to differentiate carbonized species. Considering the rich Brazilian flora, NIR studies are still underdeveloped. Our work aimed to differentiate charcoals of seven eucalypts and 10 Cerrado species based on NIR analysis and to add information to a charcoal database. Data were collected with a spectrophotometer in reflectance mode. Partial least square regression with discriminant analysis (PLS-DA) and a linear discriminant analysis (LDA) was applied to confirm the performance and potential of NIR spectra to distinguish native Cerrado species from eucalyptus species. Wavenumbers from 4,000 to 6,000 cm−1 and transversal surface presented the best results. NIR had the potential to distinguish eucalypt charcoals from Cerrado species and in comparison to reference samples. NIR is a potential tool for forestry supervision to guarantee the sustainability of the charcoal supply in Brazil and countries with similar conditions.
Morphogenesis of Iridescent Feathers in Anna’s Hummingbird Calypte anna
Authors: D’Alba Liliana , Meadows Melissa , Maia Rafael , Yeo Jong-Souk , Manceau Marie , Shawkey Matthew D 
Published: June 2021

Abstract
Color is a phenotypic trait of utmost importance, particularly in birds, which are known for their diverse color signals and color-producing mechanisms including pigment-based colors, light scattering from nanostructured feather tissues and combinations thereof. Bright iridescent plumage colors of hummingbirds are caused by light scattering by an organized array of flattened, pigment organelles, containing air-filled vesicles, called melanosomes. These hollow platelets are organized in multilayer arrays that contain numerous sharp air/melanin refractive index interfaces, producing brilliant iridescent colors. Despite their ecological significance and potential for inspiration of new optical materials, how platelets form and spatially arrange in nanostructures in growing feathers remains unknown. Here, we tested the hypothesis that melanosome formation and organization occurs mostly through passive self-assembly processes by assembling a developmental time series of growing hummingbird feathers using optical and electron microscopy. We show that hummingbird platelets contain air bubbles or vesicles upon their formation in pigment-producing cells, melanocytes. When melanosomes are transferred to neighboring keratinocytes (the cells shaping barbule structure) they drastically expand in size; and variation in this enlargement appears to be driven by physical constraints caused by the placement of the melanosomes within the barbule plate and their proximity to other melanosomes. As the barbule elongates and narrows, polymerizing feather corneous beta-protein orients melanosomes unilaterally, forcing them into a stacked configuration. These results reveal potentially novel forces driving the self-assembly of the nanostructures producing some of the brightest colors in nature.