bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncovering the microseismic signals from noisy data for high-fidelity 3D source-location imaging using deep learning
Authors: Saad Omar M. , Bai Min , Chen Yangkang 
Published: August 2021

Localizing the microseismic event plays a key role in microseismic monitoring. However, microseismic data usually suffer from a low signal-to-noise ratio (S/N), which could affect the resolution of the microseismic source location. We have developed an unsupervised deep learning approach based on variational autoencoder (VAE) and squeeze-and-excitation (SE) networks for enhancing microseismic signals, as well as suppressing noise. First, the microseismic data are divided into several overlapped patches. Second, the VAE encodes the data, extracting the significant features related to the useful signals. Finally, the extracted latent features are decoded to uncover the useful signals and discard the others. The SE network is used to guide the VAE to preserve the useful information related to the clean signal by scaling the extracted features from the encoder part and concatenating them with the features of the decoder part. Our algorithm is evaluated using several synthetic and field examples. As a result, a robust denoising performance is shown despite the existence of a high level of random and coherent noise, for example, with an S/N as low as −32.45 dB. Then, the denoised signal can be used as input data to image the source location using a reverse time migration method, leading to better location accuracy. Our algorithm performs the best when compared to benchmark methods such as f- x deconvolution and the damped multichannel singular spectrum analysis methods.
Health anxiety, perceived risk and perceived control in following recommended preventive measures during early COVID-19 response in Romania
Authors: Ștefan Simona , Fodor Liviu Andrei , Curt Ioana , Ionescu Andreea , Pantea Nadina , Jiboc Nicoleta , Tegzesiu Ana Maria 
Published: August 2021

Background
Compliance with government-recommended preventive measures represents a key factor in mitigating the negative consequences of coronavirus disease 2019 (COVID-19).

Aims
The study investigated the relation between health anxiety, perceived risk and perceived control as predictors of coronavirus disease 2019 (COVID-19)-related anxiety and preventive behaviours (both adaptive and dysfunctional/excessive) during the early pandemic response in Romania.

Method
Data were collected in April–May 2020, and the sample comprised 236 participants, 192 women, mean age 31.44 (s.d. = 10.30, age range 16–67).

Results
Our results showed that health anxiety and perceived control, but not perceived risk predicted adaptive preventive behaviours, whereas dysfunctional behaviours were predicted by health anxiety alone. COVID-19-related anxiety was predicted by health anxiety and perceived risk, with perceived control emerging as a non-significant predictor. Also, we found that the effect of health anxiety on COVID-19-related anxiety was mediated by perceived risk, and that perceived control acted as a moderator in the relation between health anxiety and dysfunctional (but not adaptive) preventive behaviours.

Conclusions
Our results suggest health anxiety is a significant predictor of COVID-19-related anxiety and preventive behaviours. Also, adaptive, but not dysfunctional, preventive behaviours were additionally predicted by perceived control, pointing to the important role of control and self-efficacy in explaining adherence to recommendations.
Local Treatment of Non-small Cell Lung Cancer with a Spray-Dried Bevacizumab Formulation
Authors: Shepard Kimberly B. , Vodak David T. , Kuehl Philip J. , Revelli David , Zhou Yue , Pluntze Amanda M. , Adam Molly S. , Oddo Julia C. , Switala Lauren , Cape Jonathan L. , Baumann John M. , Banks Michael 
Published: August 2021

AbstractLocal delivery of biotherapeutics to the lung holds great promise for treatment of lung diseases, but development of physically stable, biologically active dry powder formulations of large molecules for inhalation has remained a challenge. Here, spray drying was used to manufacture a dry powder pulmonary formulation of bevacizumab, a monoclonal antibody approved to treat non-small cell lung cancer (NSCLC) by intravenous infusion. By reformulating bevacizumab for local delivery, reduced side effects, lower doses, and improved patient compliance are possible. The formulation had aerosol properties suitable for delivery to the deep lung, as well as good physical stability at ambient temperature for at least 6 months. Bevacizumab’s anti-VEGF bioactivity was not impacted by the manufacturing process. The formulation was efficacious in an in vivo rat model for NSCLC at a 10-fold decrease in dose relative to the intravenous control.
Anderson localisation and reentrant delocalisation of tensorial elastic waves in two-dimensional fractured media
Authors: Lei Qinghua , Sornette Didier 
Published: August 2021

Abstract
We study tensorial elastic wave transport in two-dimensional densely fractured media using numerical simulations and document transitions from propagation to diffusion and to localisation/delocalisation. For large fracture stiffness, waves are propagative at the scale of the system. For small stiffness, multiple scattering prevails, such that waves are diffusive in disconnected fracture networks, and localised in connected ones with a strong multifractality of the intensity field. A re-entrant delocalisation is found in well-connected fracture networks due to energy leakage via evanescent waves and cascades of mode conversion.
Developmental single-cell transcriptomics in the Lytechinus variegatus sea urchin embryo
Authors: Massri Abdull J. , Greenstreet Laura , Afanassiev Anton , Berrio Alejandro , Wray Gregory A. , Schiebinger Geoffrey , McClay David R. 
Published: August 2021

ABSTRACT
Using scRNA-seq coupled with computational approaches, we studied transcriptional changes in cell states of sea urchin embryos during development to the larval stage. Eighteen closely spaced time points were taken during the first 24 h of development of Lytechinus variegatus (Lv). Developmental trajectories were constructed using Waddington-OT, a computational approach to ‘stitch’ together developmental time points. Skeletogenic and primordial germ cell trajectories diverged early in cleavage. Ectodermal progenitors were distinct from other lineages by the 6th cleavage, although a small percentage of ectoderm cells briefly co-expressed endoderm markers that indicated an early ecto-endoderm cell state, likely in cells originating from the equatorial region of the egg. Endomesoderm cells also originated at the 6th cleavage and this state persisted for more than two cleavages, then diverged into distinct endoderm and mesoderm fates asynchronously, with some cells retaining an intermediate specification status until gastrulation. Seventy-nine out of 80 genes (99%) examined, and included in published developmental gene regulatory networks (dGRNs), are present in the Lv-scRNA-seq dataset and are expressed in the correct lineages in which the dGRN circuits operate.
Identification of disease-relevant modulators of the SHH pathway in the developing brain
Authors: Mecklenburg Nora , Kowalczyk Izabela , Witte Franziska , Görne Jessica , Laier Alena , Mamo Tamrat M. , Gonschior Hannes , Lehmann Martin , Richter Matthias , Sporbert Anje , Purfürst Bettina , Hübner Norbert , Hammes Annette 
Published: August 2021

ABSTRACT
Pathogenic gene variants in humans that affect the sonic hedgehog (SHH) pathway lead to severe brain malformations with variable penetrance due to unknown modifier genes. To identify such modifiers, we established novel congenic mouse models. LRP2-deficient C57BL/6N mice suffer from heart outflow tract defects and holoprosencephaly caused by impaired SHH activity. These defects are fully rescued on a FVB/N background, indicating a strong influence of modifier genes. Applying comparative transcriptomics, we identified Pttg1 and Ulk4 as candidate modifiers upregulated in the rescue strain. Functional analyses showed that ULK4 and PTTG1, both microtubule-associated proteins, are positive regulators of SHH signaling, rendering the pathway more resilient to disturbances. In addition, we characterized ULK4 and PTTG1 as previously unidentified components of primary cilia in the neuroepithelium. The identification of genes that powerfully modulate the penetrance of genetic disturbances affecting the brain and heart is likely relevant to understanding the variability in human congenital disorders.
Μελέτη ολικών πρωτεϊνών CD117 και PDGFRA στον ορό ασθενών με υποβλεννογόνιους όγκους πεπτικού
Authors: Κακαβέτση Βασιλική 
Published: August 2021

ΠΕΡΙΛΗΨΗ Εισαγωγή Οι στρωματικοί όγκοι αποτελούν τους συχνότερους μεσεγχυματικούς όγκους του γαστρεντερικού σωλήνα. Σκοπός της μελέτης Ο πρωταρχικός σκοπός της μελέτης, ήταν να διερευνηθεί εάν η ανίχνευση των ολικών πρωτεϊνών CD117 και PDGFRA στον ορό των ασθενών με GISTs, μπορεί να αποτελέσει αξιόπιστο διαγνωστικό βιοδείκτη στην κλινική πράξη. Ασθενείς και μέθοδοι Είκοσι επτά (27) ασθενείς με ιστολογικά επιβεβαιωμένους GISTs, είκοσι τέσσερις (24) ασθενείς με έτερους πλήν GIST υποβλεννογόνιους όγκους, και είκοσι επτά (27) υγιείς μάρτυρες, συμμετείχαν στην εν λόγω μελέτη. Η ανίχνευση των ολικών πρωτεϊνών CD117 και PDGFRA, επιτεύχθηκε με κυτταρομετρία ροής.Αποτελέσματα Από τους 27 ασθενείς με ιστολογικά επιβεβαιωμένους GISTs, 25 ήταν ορολογικά θετικοί στην πρωτεΐνη CD117. Στην ομάδα των 27 υγιών συμμετεχόντων, όλοι πλήν ενός είχαν αρνητική πρωτεΐνη CD117 στον ορό, ενώ στους 24 ασθενείς με έτερους υποβλεννογόνιους όγκους , 22 ήταν οροαρνητικοί και 2 καταγράφηκαν με θετικές τιμές. Η ευαισθησία και ειδικότητα της μεθόδου εκτιμήθηκε να είναι 92,8% και 96,2% αντίστοιχα. Απο τον ορολογικό προσδιορισμό της πρωτεΐνης PDGFRA, όλοι οι συμμετέχοντες παρουσίασαν αρνητικές τιμές στον ορό.Συμπεράσματα Η ορολογική ανίχνευση της ολικής πρωτεΐνης CD117, παρουσίασε υψηλότερη ειδικότητα στους ασθενείς με GISTs, συγκριτικά με τις ομάδες των ασθενών με μη-GIST υποβλεννογόνιους όγκους και υγιών μαρτύρων αντίστοιχα. Δεδομένης της ευκολίας στην ανίχνευση, τα επίπεδα της ολικής CD117, μπορεί να αποτελέσουν έναν αξιόπιστο, ευαίσθητο και ειδικό κλινικό βιοδείκτη για τη διάγνωση και διαφορική διάγνωση των στρωματικών όγκων απο έτερους υποβλεννογόνιους όγκους του γαστρεντερικού σωλήνα, στην καθημερινή κλινική πρακτική.
Genome-wide regulation of CpG methylation by ecCEBPα in acute myeloid leukemia
Authors: Ogunleye Adewale J. , Romanova Ekaterina , Medvedeva Yulia A. 
Published: August 2021

Background: Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by genetic and epigenetic aberrations that alter the differentiation capacity of myeloid progenitor cells. The transcription factor CEBPα is frequently mutated in AML patients leading to an increase in DNA methylation in many genomic locations. Previously, it has been shown that ecCEBPα (extra coding CEBPα) - a lncRNA transcribed in the same direction as CEBPα gene - regulates DNA methylation of CEBPα promoter in cis. Here, we hypothesize that ecCEBPα could participate in the regulation of DNA methylation in trans. Method: First, we retrieved the methylation profile of AML patients with mutated CEBPα locus from The Cancer Genome Atlas (TCGA). We then predicted the ecCEBPα secondary structure in order to check the potential of ecCEBPα to form triplexes around CpG loci and checked if triplex formation influenced CpG methylation, genome-wide. Results: Using DNA methylation profiles of AML patients with a mutated CEBPα locus, we show that ecCEBPα could interact with DNA by forming DNA:RNA triple helices and protect regions near its binding sites from global DNA methylation. Further analysis revealed that triplex-forming oligonucleotides in ecCEBPα are structurally unpaired supporting the DNA-binding potential of these regions. ecCEBPα triplexes supported with the RNA-chromatin co-localization data are located in the promoters of leukemia-linked transcriptional factors such as MLF2. Discussion: Overall, these results suggest a novel regulatory mechanism for ecCEBPα as a genome-wide epigenetic modulator through triple-helix formation which may provide a foundation for sequence-specific engineering of RNA for regulating methylation of specific genes.
Das internationale Autorenliedfestival „Lehesaju Muusika“ in Tartu als spezifische Form der Kulturvermittlung und Analyseobjekt für Mehrsprachigkeitsforschung
Authors: Shakhova Anastasia 
Published: August 2021

The Lehesaju Muusika International Music and Poetry Festival in Tartu as a Specific Form of Cultural Mediation and Object of Analysis for Research on Multilingualism. The paper focuses on the multilingual discourse of the Lehesaju Muusika international music and poetry festival, which takes place annually in Tartu, Estonia. Being an international cultural event organised by ethnic minorities, Lehesaju Muusika represents a unique source of empirical data for research on multilingualism. The festival attracts songwriters and performers of the so-called ‘author song’ or ‘bard song’ not only from Estonia, but also from all over the world. The key feature of this genre is the dominance of the text over the music.
The spatial organisation of a concert hall represents a specific power constellation within a microsocial structure. Performing artists have the power to decide in which language they perform and address the multilingual audience, while the audience itself has an indirect effect on this decision. The artist’s dialogue with the audience represents a peculiar discursive entity within the discourse of the festival. Code-switching appears to be one of the inherent characteristics of this discursive entity.
The present paper summarises some key features of international music and poetry festivals as multilingual cultural events, focusing on the discourse of the Lehesaju Muusika festival. It offers a brief analysis of the audience’s language profile based on the results of a microsociological case study carried out during the latest festival, in 2019. To illustrate the complexity of the multilingual communication during the festival, three situations of code-switching during the performance of an Estonian native speaker in front of the multilingual audience are described and analysed.
MicroRNA-183attenuates osteoarthritic pain by inhibiting theTGFα-mediatedCCL2/CCR2signalling axis
Authors: Tao Zirong , Zhou Yang , Zeng Biyun , Yang Xucheng , Su Manman 
Published: August 2021

AimsMicroRNA-183 ( miR-183) is known to play important roles in osteoarthritis (OA) pain. The aims of this study were to explore the specific functions of miR-183 in OA pain and to investigate the underlying mechanisms.MethodsClinical samples were collected from patients with OA, and a mouse model of OA pain was constructed by surgically induced destabilization of the medial meniscus (DMM). Reverse transcription quantitative polymerase chain reaction was employed to measure the expression of miR-183, transforming growth factor α (TGFα), C-C motif chemokine ligand 2 ( CCL2), proinflammatory cytokines (interleukin (IL)-6, IL-1β, and tumour necrosis factor-α ( TNF-α)), and pain-related factors (transient receptor potential vanilloid subtype-1 ( TRPV1), voltage-gated sodium 1.3, 1.7, and 1.8 ( Nav1.3, Nav1.7, and Nav1.8)). Expression of miR-183 in the dorsal root ganglia (DRG) of mice was evaluated by in situ hybridization. TGFα, CCL2, and C-C chemokine receptor type 2 ( CCR2) levels were examined by immunoblot analysis and interaction between miR-183 and TGFα, determined by luciferase reporter assay. The extent of pain in mice was measured using a behavioural assay, and OA severity assessed by Safranin O and Fast Green staining. Immunofluorescent staining was conducted to examine the infiltration of macrophages in mouse DRG.ResultsmiR-183 was downregulated in tissue samples from patients and mice with OA. In DMM mice, overexpression of miR-183 inhibited the expression of proinflammatory cytokines ( IL-6, IL-1β, TNF-α) and pain-related factors ( TRPV1, Nav1.3, Nav1.7, Nav1.8) in DRG. OA pain was relieved by miR-183-mediated inhibition of macrophage infiltration, and dual luciferase reporter assay demonstrated that miR-183 directly targeted TGFα.ConclusionOur data demonstrate that miR-183 can ameliorate OA pain by inhibiting the TGFα- CCL2/ CCR2 signalling axis, providing an excellent therapeutic target for OA treatment. Cite this article: Bone Joint Res 2021;10(8):548–557.
Propositions for Race-Based Research in Intellectual and Developmental Disabilities
Authors: Johnson Khalilah Robinson , Bogenschutz Matthew , Peak Kierra 
Published: August 2021

Abstract
A nuanced understanding of disparities impacting racialized people with intellectual and developmental disabilities (IDD) requires scholars employ research methods that make visible the structural factors that influence outcomes. Following the work of Tukufu Zuberi and Eduardo Bonilla-Silva, we explore race-based methodological considerations for disparities research with Black people with IDD. Specifically, we discuss (a) structural racism in research methods, employing disability critical race theory as a framework, (b) the absence of Black voices and Black scholarship, (c) the abstraction and misuse of race as a variable, and (d) mapping race as a point of discussion in the IDD discourse. Implications for research are discussed and recommendations for contextualizing race, ensuring equity in representation and dissemination, and amplifying the voices of Black scholars are provided.
I'm Trying to Make Myself Happy: Black Students With Intellectual and Developmental Disabilities and Families on Promoting Self-Determination During Transition
Authors: Scott LaRon A. , Thoma Colleen A. , Gokita Tonya , Bruno Lauren , Ruiz Amber Brown , Brendli Katherine , Taylor Joshua P. , Vitullo Vivian 
Published: August 2021

Abstract
Promoting self-determination for students with disabilities has proven to be a critical component of effective transition planning. However, researchers seldom consider race when promoting self-determination for people with disabilities. The purpose of the current phenomenological research investigation was to explore how Black youth with intellectual and developmental disabilities (IDD) and their families explain transition planning experiences that promote and hinder self-determination. We found that participants in the current study experienced some hurdles during their transition experiences that they perceive are rooted in systemic and structural racism and ableism that prompted advocacy, family engagement, inclusion, building knowledge of rights, and other emergent strategies to promote self-determination. Findings from the current preliminary investigation have implications for transition and self-determination research, as well as improving the quality of services and support for Black youth with IDD and their families.
Risk of a permanent work-related disability pension after incident venous thromboembolism in Denmark: A population-based cohort study
Authors: Jørgensen Helle , Horváth-Puhó Erzsébet , Laugesen Kristina , Brækkan Sigrid , Hansen John-Bjarne , Sørensen Henrik Toft 
Published: August 2021

Background
Long-term complications of venous thromboembolism (VTE) hamper physical function and impair quality of life; still, it remains unclear whether VTE is associated with risk of permanent work-related disability. We aimed to assess the association between VTE and the risk of receiving a permanent work-related disability pension and to assess whether this association was explained by comorbidities such as cancer and arterial cardiovascular disease.

Methods and findings
A Danish nationwide population-based cohort study consisting of 43,769 individuals aged 25 to 66 years with incident VTE during 1995 to 2016 and 218,845 birth year-, sex-, and calendar year-matched individuals from the general population, among whom 45.9% (N = 120,540) were women, was established using Danish national registries. The cohorts were followed throughout 2016, with permanent work-related disability pension as the outcome. Hazard ratios (HRs) with 95% confidence intervals (CIs) for disability pension were computed and stratified by sex and age groups (25 to 34, 35 to 44, 45 to 54, and 55 to 66 years of age) and adjusted for comorbidities and socioeconomic variables.
Permanent work-related disability pensions were granted to 4,415 individuals with VTE and 9,237 comparison cohort members (incidence rates = 17.8 and 6.2 per 1,000 person-years, respectively). VTE was associated with a 3-fold (HR 3.0, 95% CI: 2.8 to 3.1) higher risk of receiving a disability pension. Adjustments for socioeconomic status and comorbidities such as cancer and cardiovascular diseases reduced the estimate (HR 2.3, 95% CI: 2.2 to 2.4). The risk of disability pension receipt was slightly higher in men than in women (HR 2.5, 95% CI: 2.3 to 2.6 versus HR 2.1, 95% CI: 2.0 to 2.3). As this study is based on medical and administrative registers, information on post-VTE care, individual health behavior, and workplace factors linked to disability pension in the general population are lacking. Furthermore, as disability pension schemes vary, our results might not be directly generalizable to other countries or time periods.

Conclusions
In this study, incident VTE was associated with increased risk of subsequent permanent work-related disability, and this association was still observed after accounting for comorbidities such as cancer and cardiovascular diseases. Our results emphasize the social consequences of VTE and may help occupational and healthcare professionals to identify vulnerable individuals at risk of permanent exclusion from the labor market after a VTE event.
Efficacy and safety of a combined treatment of sodium stibogluconate at 20mg/kg/day with upper maximum daily dose limit of 850mg and Paromomycin 15mg/kg/day in HIV negative visceral leishmaniasis patients. A retrospective study, northwest Ethiopia
Authors: Tamiru Aschalew , Mohammed Rezika , Atnafu Saba , Medhin Girmay , Hailu Asrat 
Published: August 2021

Background
Visceral leishmaniasis (VL) is one of the most neglected tropical infectious diseases. It is fatal if left untreated. The objective of this study was to assess the efficacy and safety of 17-day injections of combined regimen of sodium stibogluconate and paromomycin (SSG/PM) in HIV-negative VL patients.

Methods
A retrospective analysis of medical records of VL patients treated in the University of Gondar Hospital during period 2012–2019 was carried out.

Results
A total of 2836 patients were treated for VL from 2012 to 2019. Of these 1233 were treated with SSG-PM, and 1000 of them were included in the study. Initial cure was achieved in 922 (92.2%) patients. The frequency of treatment failure, treatment interruptions, default and deaths respectively were 30 (3%), 20 (2%), 13 (1.3%) and 15 (1.5%). Among 280 patients who completed 6-month follow up, the final cure was 93.9% (263/280), 4 (1.4%) relapsed and 13 (4.6%) developed post-kala-azar dermal leishmaniasis (PKDL). The most common adverse events (AEs) were raised liver transaminases (35.1%; 351 patients), injection site pain (29.1%, 291 patients) and raised serum alpha-amylase (29.1%, 291 patients). Factors associated with poor treatment outcomes were sepsis, pneumonia, and adverse events.

Conclusion
A combination of SSG at 20mg/kg with upper daily maximum dose of 850mg and PM was effective for achieving initial cure at end of treatment and safe for treatment of HIV negative VL patients in northwestern Ethiopia. Our data are consistent with previous reports and confirms effectiveness of SSG/PM treatment regimen in the Eastern African countries. Efficacy at 6-months (93.9%) was estimated on data derived from patients who completed follow up and needs to be interrogated by future studies.