bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wolfberry‐derived zeaxanthin dipalmitate delays retinal degeneration in a mouse model of retinitis pigmentosa through modulating STAT3, CCL2 and MAPK pathways
Authors: Liu Feng , Liu Xiaobin , Zhou Yamin , Yu Yankun , Wang Ke , Zhou Zhengqun , Gao Hao , So Kwok‐Fai , Vardi Noga , Xu Ying 
Published: July 2021

AbstractRetinitis pigmentosa (RP) is a group of inherited photoreceptor degeneration diseases that causes blindness without effective treatment. The pathogenesis of retinal degeneration involves mainly oxidative stress and inflammatory responses. Zeaxanthin dipalmitate (ZD), a wolfberry‐derived carotenoid, has anti‐inflammatory and anti‐oxidative stress effects. Here we investigated whether these properties of ZD can delay the retinal degeneration in rd10 mice, a model of RP, and explored its underlying mechanism. One shot of ZD or control vehicle was intravitreally injected into rd10 mice on postnatal day 16 (P16). Retinal function and structure of rd10 mice were assessed at P25, when rods degenerate substantially, using a visual behavior test, multi‐electrode‐array recordings and immunostaining. Retinal pathogenic gene expression and regulation of signaling pathways by ZD were explored using transcriptome sequencing and western blotting. Our results showed that ZD treatment improved the visual behavior of rd10 mice and delayed the degeneration of retinal photoreceptors. It also improved the light responses of photoreceptors, bipolar cells and retinal ganglion cells. The expression of genes that are involved in inflammation, apoptosis and oxidative stress were up‐regulated in rd10 mice, and were reduced by ZD. ZD further reduced the activation of two key factors, signal transducer and activator of transcription 3 and chemokine (C‐C motif) ligand 2, down‐regulated the expression of the inflammatory factor GFAP, and inhibited extracellular signal regulated protein kinases and P38, but not the JNK pathways. In conclusion, ZD delays the degeneration of the rd10 retina both morphologically and functionally. Its anti‐inflammatory function is mediated primarily through the signal transducer and activator of transcription 3, chemokine (C‐C motif) ligand 2 and MAPK pathways. Thus, ZD may serve as a potential clinical candidate to treat RP.
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Covid‐19 pandemic and consumer‐employee‐organization wellbeing: A dynamic capability theory approach
Authors: Nayal Preeti , Pandey Neeraj , Paul Justin 
Published: July 2021

AbstractThe consumers, employees, and organizations have been deeply impacted by Covid‐19 pandemic. The present study offers a detailed coping mechanism for organizations based on the extant literature and content analysis of responses of senior management executives. The study is based on semi‐structured long interviews with senior executives from various industries. Various measures have been identified for firms as a coping strategy for crisis management and customer well‐being. Covid‐19 has changed the way individuals live. This study suggests that firms should come forward for well‐being of their employees in this new normal. One of the major shifts due to pandemic is in consumer behavior and their consumption habits. Pandemic made consumers go for digitization, think for hygiene, sustainability, and local products. And firms should keep the changed consumer behavior in mind while manufacturing the products. Furthermore, present study suggests that firms can create a positive image of their company by doing CSR activities for society's well‐being.
Coffee pulp supplement affects antioxidant status and favors anti‐aging of skin in healthy subjects
Authors: Tseng Ya‐Ping , Liu Cheng , Chan Leong‐Perng , Liang Chia‐Hua 
Published: July 2021

AbstractBackgroundCoffee and coffee products are known potentially to reduce levels of oxidative stress biomarkers in humans.ObjectiveThis investigation evaluates the effects of coffee pulp extract as a functional supplement (in coffee pulp drink, CPD) and a cosmetic ingredient (coffee pulp serum, CPS).Patients/MethodsThe effects of CPD and CPS for anti‐oxidation and anti‐aging were investigated. Forty subjects were randomly allocated to CPD or placebo drink groups (50 ml of a CPD/placebo drink daily for 8 weeks for each subject), and another 40 subjects were recruited to CPS or placebo serum groups (about 3 ml of a CPS/placebo serum day and night/daily for 4 weeks for each subject) in a double‐blind study.ResultsThe CPD and CPS (20%) can increase free radical scavenging activities by 93.3% and 85% (p < 0.001) for DPPH, 94.5% and 61.3% (p < 0.01) for ABTS·+, 43.8% and 15.3% (p < 0.05) for NO· than placebo. The inhibition of tyrosinase activity was increased by 91.6% and 51.0% (p < 0.05) after CPD and CPS application. The CPD comprehensively improved the moisture, brightness, elasticity, spotting, texture, and collagen content of skin for most subjects after 8 weeks, relative to the baseline without treatment (p < 0.05). After 4 weeks of CPS serum consumption, the brightness, elasticity, spotting, UV spots, and collagen content of skin were slightly better than those at week 0 (p < 0.05).ConclusionsThe daily consumption of coffee pulp extract products can slow the skin aging process and improve skin health.
Laparoscopic repair of segmental obturator nerve injury defect using an artificial nerve conduit: A case report
Authors: Matsumoto Tsuyoshi , Banda Chihena H. , Kondo Eiji , Yoshida Kenta , Hirata Toru , Ikeda Tomoaki , Narushima Mitsunaga 
Published: July 2021

AbstractObturator nerve injury is an uncommon complication frequently associated with pelvic gynecologic or urologic cancer surgery. It can lead to disability or adversely affect quality of life. Large segmental defects are particularly difficult to manage as the limited mobility of the nerve prevents tension‐free direct end‐to‐end anastomosis. A 36‐year‐old woman with cervical cancer underwent sentinel lymph node biopsy, laparoscopic radical hysterectomy, and bilateral adnexectomy. During the procedure, the sentinel lymph node (right obturator node) adherent to the obturator nerve was resected together with the nerve segment leaving a 3 cm defect. Immediate laparoscopic obturator nerve repair was performed using an artificial nerve conduit leading to successful recovery. We report this unique case due to rarity of large segmental obturator nerve defects and present laparoscopic nerve repair with artificial nerve conduits as a useful treatment alternative of these important injuries, without nerve donor site morbidity.
A Multi‐Level Model of I‐deals in Workgroups: Employee and Coworker Perceptions of Leader Fairness, I‐Deals and Group Performance
Authors: Anand Smriti , Meuser Jeremy D. , Vidyarthi Prajya R. , Liden Robert C. , Rousseau Denise M. , Ekkirala Srinivas 
Published: July 2021

AbstractWe test theory regarding the within‐group dynamics linking employees’ leader fairness judgments to the receipt of idiosyncratic deals (‘i‐deals’), and how differences between workgroups in the extent and variability of i‐deals influence workgroup performance. We assert that employees, their co‐workers, and the workgroup leader are three key stakeholders to i‐deals. Drawing on fairness heuristic theory, we hypothesize that employees are more likely to obtain i‐deals when they view their workgroup leaders as procedurally fair. Further, individual perceptions of leader fairness exist within the context of their co‐workers’ perceptions of leader fairness, that is, (in)congruence between the two affects individual i‐deals. At the workgroup level, we hypothesize a positive association between the access and extent of i‐deals and workgroup performance. Employing polynomial regression on data from 258 employees nested in 69 workgroups, we find that congruence between individual and co‐workers’ perceptions of leader fairness is positively related to the individual’s receipt of i‐deals; incongruence has an asymmetric effect, such that individual perceptions matter more. Finally, within‐group access and extent of i‐deals are positively related to group performance.
Validation of actigraphy in hospitalised newborn infants using video polysomnography
Authors: Unno Mitsuaki , Morisaki Toshihiro , Kinoshita Masahiro , Saikusa Mamoru , Iwata Sachiko , Fukaya Satoko , Yamashita Yushiro , Nakayama Meiho , Saitoh Shinji , Iwata Osuke 
Published: July 2021

SummaryActigraphy has been established as a reliable sleep assessment tool in adults; however, its utility in newborns remains unknown. Validation of actigraphy in newborns may provide a significant insight into the physiological and pathological acquisition process of mature diurnal sleep patterns and subsequent morbidities in both newborns and their mothers. Thus, the present study aimed to evaluate the accuracy of sleep–wake detection by overnight actigraphy in a cohort of newborns. Simultaneous recording of polysomnography and actigraphy data was performed in 40 newborns admitted to a tertiary neonatal intensive care unit (NICU). A mixed‐effects logistic regression model to explain the sleep state identified by polysomnography was employed using the actigraphic activity score as a fixed independent variable and the individual newborn’s identity as a random effect. To evaluate the usefulness of the actigraphic activity score as a surrogate marker of sleep, a receiver operating characteristic (ROC) curve analysis was performed using the variables that were used in the mixed‐effects logistic regression model, and the area under the curve (AUC) was assessed. The results showed that polysomnography‐determined sleep epochs were associated with a smaller activity index on actigraphy (odds ratio per 10 activity indices increase 0.81, 95% confidence interval [CI] 0.79–0.84). The AUC for the ROC curve was 0.87 (95% CI 0.87–0.88, range 0.54–0.99). An activity score of 124 showed the maximum overall accuracy (90.2%, 95% CI 87.7–92.1). Our present study suggests that sleep–wake states of NICU‐hospitalised newborns can be precisely determined using actigraphy on the ankle.
Effects of dietary tea tree (Melaleuca alternifolia) oil and feeding patterns on the zootechnical performance and nonspecific immune response of the giant freshwater prawn (Macrobrachium rosenbergii)
Authors: Liu Mingyang , Sun Cunxin , Xu Pao , Liu Bo , Zheng Xiaochuan , Liu Bo , Zhou Qunlan 
Published: July 2021

AbstractThis study investigated the effects of dietary tea tree oil (TTO) supplementation and feeding patterns on the growth and nonspecific immunity of Macrobrachium rosenbergii. Prawns were randomly assigned into four patterns. Patterns 1 (P1) and 4 (P4): prawns were fed with a basal diet and basal diet supplemented with 100 mg/kg of TTO, respectively; Patterns 2 (P2) and 3 (P3): prawns were fed with the basal diet supplemented with 100 mg/kg of TTO at 1‐ and 2‐week intervals, respectively. A significant increase in growth performance was observed in the P3 and P4 compared with P1. The activities of antioxidant enzyme were significantly elevated in the P3 and P4 compared with the P1. The concentration of haemolymph malondialdehyde was significantly lower in the P3 and P4 than the P1. The haemolymph level of IL‐1 and TNF‐α was significantly lower in the P3 than the P4. The expression of toll and dorsal was significantly lower in the P3 than the P1. However, the expression of peroxiredoxin‐5 was significantly higher in the P3 than the P1. Overall, these findings indicated that feeding 100 mg/kg of TTO at 2‐week intervals significantly improved the growth performance and nonspecific immunity of M. rosenbergii.
Provision and utilisation of health and nutrition services during COVID‐19 pandemic in urban Bangladesh
Authors: Nguyen Phuong Hong , Sununtnasuk Celeste , Pant Anjali , Tran Mai Lan , Kachwaha Shivani , Ash Deborah , Ali Mohsin , Ireen Santhia , Kappos Kristen , Escobar‐Alegria Jessica , Menon Purnima 
Published: July 2021

AbstractThe COVID‐19 pandemic is expected to have profound effects on healthcare systems, but little evidence exists on service provision, utilisation, or adaptations. This study aimed to (1) examine the changes to health and nutrition service delivery and utilisation in urban Bangladesh during and after enforcement of COVID‐19 restrictions and (2) identify adaptations and potential solutions to strengthen delivery and uptake. We conducted longitudinal surveys with health care providers (n = 45), pregnant women (n = 40), and mothers of children <2 years (n = 387) in February 2020 (in‐person) and September 2020 (by phone). We used Wilcoxon matched‐pairs signed‐rank tests to compare the changes before and during the pandemic. Services delivery for women and children which require proximity were severely affected; weight and height measurements fell by 20–29 percentage points (pp) for pregnant women and 37–57 pp for children, and child immunisations fell by 38 pp. Declines in service utilisation were large, including drops in facility visitations (35 pp among pregnant women and 67 pp among mothers), health and nutrition counselling (up to 73 pp), child weight measurements (50 pp), and immunisations (61 pp). The primary method of adaptation was provision of services over phone (37% for antenatal care services, 44%–49% for counselling). Despite adaptations to service provision, continued availability of routine maternal and child health services did not translate into service utilisation. Further investments are needed to provide timely and accurate information on COVID‐19 to the general public, improve COVID‐19 training and provide incentives for health care providers and ensure availability of personal protective equipment for providers and beneficiaries.
The roles of aridification and sea level changes in the diversification and persistence of freshwater fish lineages
Authors: Buckley Sean James , Brauer Chris , Unmack Peter J. , Hammer Michael P. , Beheregaray Luciano B. 
Published: July 2021

AbstractWhile the influence of Pleistocene climatic changes on divergence and speciation has been well‐documented across the globe, complex spatial interactions between hydrology and eustatics over longer timeframes may also determine species evolutionary trajectories. Within the Australian continent, glacial cycles were not associated with changes in ice cover and instead largely resulted in fluctuations from moist to arid conditions across the landscape. We investigated the role of hydrological and coastal topographic changes brought about by Plio‐Pleistocene climatic changes on the biogeographic history of a small Australian freshwater fish, the southern pygmy perch Nannoperca australis. Using 7958 ddRAD‐seq (double digest restriction‐site associated DNA) loci and 45,104 filtered SNPs, we combined phylogenetic, coalescent and species distribution analyses to assess the various roles of aridification, sea level and tectonics and associated biogeographic changes across southeast Australia. Sea‐level changes since the Pliocene and reduction or disappearance of large waterbodies throughout the Pleistocene were determining factors in strong divergence across the clade, including the initial formation and maintenance of a cryptic species, N. 'flindersi'. Isolated climatic refugia and fragmentation due to lack of connected waterways maintained the identity and divergence of inter‐ and intraspecific lineages. Our historical findings suggest that predicted increases in aridification and sea level due to anthropogenic climate change might result in markedly different demographic impacts, both spatially and across different landscape types.
Sodium‐glucose cotransporter 2 inhibitors for diabetes mellitus control after kidney transplantation: Review of the current evidence
Authors: Kanbay Mehmet , Demiray Atalay , Afsar Baris , Karakus Kagan E. , Ortiz Alberto , Hornum Mads , Covic Adrian , Sarafidis Pantelis , Rossing Peter 
Published: July 2021

AbstractSodium‐glucose cotransporter type 2 inhibitors (SGLT2i) are promising drugs to treat chronic kidney disease patients with or without diabetes mellitus (DM). Besides improving glycemic control, SGLT2i are cardioprotective and kidney protective and decrease bodyweight, serum uric acid, blood pressure, albuminuria and glomerular hyperfiltration. These effects may benefit graft function and survival in kidney transplant (KT) patients. In this review, we evaluate data on the efficacy and safety of SGLT2i for KT patients with DM. Eleven studies with 214 diabetic KT patients treated with SGLT2i have been reported. SGLT2i lowered haemoglobin A1c and bodyweight. While glomerular filtration rate may be reduced in the short‐term, it remained similar to baseline after 3–12 months. In two studies, blood pressure decreased and remained unchanged in the others. There were no significant changes in urine protein to creatinine ratio. Regarding safety, 23 patients had urinary tract infections, 2 patients had a genital yeast infection, one had acute kidney injury, and one had mild hypoglycaemia. No cases of ketoacidosis or acute rejection were reported. In conclusion, the limited experience so far suggests that SGLT2i are safe in KT patients with DM, decrease bodyweight and improve glycemic control. However, some of the benefits observed in larger studies in the non‐KT population have yet to be demonstrated in KT recipients, including preservation of kidney function, reduction in blood pressure and decreased proteinuria.
Nuclear factor Y subunit GmNFYA competes with GmHDA13 for interaction with GmFVE to positively regulate salt tolerance in soybean
Authors: Lu Long , Wei Wei , Tao Jian‐Jun , Lu Xiang , Bian Xiao‐Hua , Hu Yang , Cheng Tong , Yin Cui‐Cui , Zhang Wan‐Ke , Chen Shou‐Yi , Zhang Jin‐Song 
Published: July 2021

AbstractSoybean is an important crop worldwide, but its production is severely affected by salt stress. Understanding the regulatory mechanism of salt response is crucial for improving the salt tolerance of soybean. Here, we reveal a role for nuclear factor Y subunit GmNFYA in salt tolerance of soybean likely through the regulation of histone acetylation. GmNFYA is induced by salt stress. Overexpression of GmNFYA significantly enhances salt tolerance in stable transgenic soybean plants by inducing salt‐responsive genes. Analysis in soybean plants with transgenic hairy roots also supports the conclusion. GmNFYA interacts with GmFVE, which functions with putative histone deacetylase GmHDA13 in a complex for transcriptional repression possibly by reducing H3K9 acetylation at target loci. Under salt stress, GmNFYA likely accumulates and competes with GmHDA13 for interaction with GmFVE, leading to the derepression and maintenance of histone acetylation for activation of salt‐responsive genes and finally conferring salt tolerance in soybean plants. In addition, a haplotype I GmNFYA promoter is identified with the highest self‐activated promoter activity and may be selected during future breeding for salt‐tolerant cultivars. Our study uncovers the epigenetic regulatory mechanism of GmNFYA in salt‐stress response, and all the factors/elements identified may be potential targets for genetic manipulation of salt tolerance in soybean and other crops.
Granulomatous dermatitis following measles, mumps, and rubella vaccination
Authors: Samaran Quentin , Clark Evangéline , Secco Léo‐Paul , Poujade Laura , Schwob Emilie , Bessis Didier , Raison‐Peyron Nadia 
Published: July 2021

AbstractGranulomatous dermatitis following the administration of various vaccines has previously been reported. However, cases of cutaneous granulomatosis following the measles, mumps, and rubella (MMR) vaccine have not yet been reported. We report the case of a 3‐year‐old boy with a granuloma annulare‐like reaction following MMR vaccination.
Outcomes of liver transplantation for mitochondrial respiratory chain disorder in children
Authors: Uchida Hajime , Sakamoto Seisuke , Shimizu Seiichi , Yanagi Yusuke , Fukuda Akinari , Horikawa Reiko , Ito Reiko , Matsunaga Ayako , Murayama Kei , Kasahara Mureo 
Published: July 2021

AbstractAimMitochondrial respiratory chain disorder (MRCD) can cause acute liver failure (ALF), which may necessitate liver transplantation (LT). However, MRCD is often difficult to diagnose before LT and the indications of LT are controversial due to the likelihood of progressive neurological disease. The present study further characterized the patient population and described the outcomes.MethodsThirteen patients who underwent LT for MRCD from November 2005 to May 2020 were enrolled in this study.ResultsSix of 13 MRCD patients were diagnosed with a mitochondrial inner membrane protein 17‐related mitochondrial DNA depletion syndrome (MTDPS). Overall, nine survived with a median follow‐up of 1.8 years (IQR, 1.3–5.1 years); four died within 2 years. In the long‐term, seven survivors showed no progression of hypotonia after LT and attended a normal kindergarten or primary school. Neurological abnormalities were observed in two survivors, including vison loss related to Leber's hereditary optic neuropathy in one patient and psychomotor retardation related to Leigh syndrome in the other. Three non‐survivors after LT were diagnosed with MTDPS and died of severe pulmonary hypertension, which had developed at 8, 9, and 18 months after LT (n=1 each). The remaining patient died of postoperative respiratory infection with respiratory syncytial virus.ConclusionThe long‐term results support the performance of LT in patients with MRCD, although a genetic diagnosis is preferable for determining the accurate indications for LT in these patients. Furthermore, care should be taken to avoid complications due to mitochondrial dysfunction during the long‐term follow‐up.
Exogenous melatonin‐mediated regulation of K+/Na+ transport, H+‐ATPase activity and enzymatic antioxidative defence operate through endogenous hydrogen sulphide signalling in NaCl‐stressed tomato seedling roots
Authors: Siddiqui M. H. , Khan M. N. , Mukherjee S. , Basahi R. A. , Alamri S. , Al‑Amri A. A. , Alsubaie Q. D. , Ali H. M. , Al‐Munqedhi B. M. A. , Almohisen I. A. A. 
Published: July 2021

Abstract

Melatonin (Mel) and hydrogen sulphide (H2S) have emerged as potential regulators of plant metabolism during abiotic stress. Presence of excess NaCl in the soil is one of the main causes of reduced crop productivity worldwide. The present investigation examines the role of exogenous Mel and endogenous H2S in tomato seedlings grown under NaCl stress.

Effect of 30 µm Mel on endogenous synthesis of H2S was examined in roots of NaCl‐stressed (200 mm) tomato seedlings. Also, the impact of treatments on the oxidative stress markers, transport of K+ and Na+, and activity of H+‐ATPase and antioxidant enzymes was assessed.

Results show that NaCl‐stressed seedlings supplemented with 30 µm Mel had increased levels of endogenous H2S through enhanced L‐cysteine desulfhydrase activity. Mel in association with H2S overcame the deleterious effect of NaCl and induced retention of K+ that maintained a higher K+/Na+ ratio. Use of plasma membrane inhibitors and an H2S scavenger revealed that Mel‐induced regulation of K+/Na+ homeostasis in NaCl‐stressed seedling roots operates through endogenous H2S signalling. Synergistic effects of Mel and H2S also reduced the generation of ROS and oxidative destruction through the enhanced activity of antioxidant enzymes.

Thus, it is suggested that the protective function of Mel against NaCl stress operates through an endogenous H2S‐dependent pathway, wherein H+‐ATPase‐energized secondary active transport regulates K+/Na+ homeostasis.