bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Alcoholic and Nanoparticle Additives on the Performance, Combustion and Emission Analysis of Biodiesel blended Common Rail Direct Injection Diesel Engine
Authors: Nutakki Prabhu Kishore , Gugulothu Santhosh Kumar , Ramachander Jatoth , Sivasurya Mulugundam 
Published: February 2021

Abstract
This paper deals with the study on the influence of the effects of iron oxide nanoparticle additives when added to ternary fuel (diesel + Mahua methyl ester + Pentanol) on the emission, combustion and performance characteristics of a four stroke, single cylinder, common rail direct injection diesel engine working at a constant speed and varying operating scenarios. Doping is done in various proportions to the nanoparticle additives with the help of a homogenizer and ultrasonicator where the cationic surfactant used is CTAB (cetyl trimethyl ammonium bromide). Iron oxide nanoparticles were used as additives in fuel in the dosages of 40 ppm, 80 ppm & 120 ppm respectively and TF (Ternary fuel) is obtained by mixing 10% pentanol, 20% Mahua and 70% diesel together is used for the experimental study. The experimental study revealed that while using the nanoparticle additives blended ternary fuel (i.e., TF80) the number of harmful pollutants like smoke (5.38%), HC (6.39%), carbon monoxide (10.24%) and NOx etc. has reduced to a considerable extent and there was a commendable improvement in the BTE by 8.8%. So, we can summarize that when ternary fuel and nano additives are blended together the combustion and performance of the engine was improved considerably and pollutant emissions were decreased.
Why do some inter-organisational collaborations in healthcare work when others do not? A realist review
Authors: Aunger Justin Avery , Millar Ross , Greenhalgh Joanne , Mannion Russell , Rafferty Anne Marie , McLeod Hugh 
Published: February 2021

Abstract
Background Inter-organisational collaboration is increasingly prominent within contemporary healthcare systems. A range of collaboration types such as alliances, networks, and mergers have been proposed as a means to turnaround organisations, by reducing duplication of effort, enabling resource sharing, and promoting innovations. However, in practice, due to the complexity of the process, such efforts are often rife with difficulty. Notable contributions have sought to make sense of this area, however further understanding is needed in order to gain a better understanding of why some inter-organisational collaborations work when others do not, to be able to more effectively implement collaborations in the future. Methods Realist review methodology was used with the intention of formulating context-mechanism-outcome configurations (CMOCs) to explain how inter-organisational collaborations work and why., combining systematic and purposive literature search techniques . The systematic review encompassed searches for reviews, commentaries, opinion pieces and case studies on HMIC, Medline, PsycINFO, and Social Policy and Practice databases and further searches were conducted using Google Scholar. Data were extracted from included studies according to relevance to the realist review. Results Fifty-three papers were included, informing the development of programme theories of how, why, and when inter-organisational collaborations in healthcare work. Formulation of our programme theories incorporated the concepts of Partnership Synergy and Collaborative Inertia and found that it was essential to consider mechanisms underlying partnership functioning, such as building trust and faith in the collaboration to maximise synergy and thus collaborative performance. More integrative or mandated collaboration may lean more heavily on contract to drive collaborative behaviour. Conclusion As the first realist review of inter-organisational collaborations in healthcare as an intervention for improvement, this review provides actionable evidence for policymakers and implementers, enhancing understanding of mechanisms underlying the functioning and performing of inter-organisational collaborations, as well as how to configure the context to aid success. Next steps in this research will test the results against further case studies and primary data to produce a further refined theory. Review registration This review is registered at PROSPERO with ID CRD42019149009. Keywords Collaboration, partnership working, integration, healthcare, improvement, realist review, realist synthesis, context, programme theory, implementation
Social vulnerability of children aged 5 to 15 years to malaria in Madagascar: secondary analysis of 3 qualitative studies of LLIN use
Authors: NJATOSOA Ammy Fiadanana , Mattern Chiarella , Pourette Dolorès , Kesteman Thomas , Rakotomanana Elliot , Rahaivondrafahitra Bakoly , Andriamananjara Mauricette , Harimanana Aina , Razafindrakoto Jocelyn , Raboanary Emma , Andrianasolo Andry , Rogier Christophe 
Published: February 2021

Abstract
Background: Although it is accepted that long lasting insecticidal net (LLIN) use is an effective means to prevent malaria, children aged 5 to 15 years do not appear to be sufficiently protected in Madagascar; the malaria prevalence is highest in this age group. The purpose of this article is to summarize recent qualitative studies describing LLIN use among children aged 5-15 years and explore options to increase their use in this age group.Methods: Qualitative data from three studies on malaria conducted between 2012 and 2016 in 10 districts of Madagascar were analyzed. These studies cover all malaria epidemiological profiles and 10 of the 18 existing ethnic groups in Madagascar. A thematic analysis was conducted on the collected data from semi-structured interviews, direct observation data, and informal interviews.Results: A total of 192 semi-structured interviews were conducted. LLINs are generally perceived positively because they protect the health and well-being of users. However, regional representations of mosquito nets may contribute to LLIN nonuse by children over 5 years of age including the association between married status and LLIN use, which leads to the refusal of unmarried young men to sleep under LLINs; the custom of covering the dead with a mosquito net, which leads to fear of LLIN use; and taboos governing sleeping spaces for siblings of opposite sexes, which leads to LLIN shortages in households. Children under 5 years of age are known to be the most vulnerable age group for acquiring malaria and therefore are prioritized for LLIN use when there are limited supplies in households. In contrast, children over 5 years of age, who are perceived to be at less risk for malaria, often sleep without LLINs.Conclusions: Perceptions, social practices and regional beliefs regarding LLINs and vulnerability to malaria contribute to the nonuse of LLINs among children over 5 years of age in Madagascar. Modifying LLIN policies to account for these factors may increase LLIN use in this age group and reduce disease burden.Trial registration: Not applicable
The effect of patient empowerment on anxiety, depression or health-related quality of life in patients with type 2 diabetes: a systematic review protocol
Authors: Duarte-Díaz Andrea , Perestelo-Pérez Lilisbeth , Rivero-Santana Amado , Peñate Wenceslao , Álvarez-Pérez Yolanda , Ramos-García Vanesa , González-Pacheco Himar , Goya-Arteaga Libertad , Bonis-Braun Miriam de , González-Martín Silvia , Ramallo-Fariña Yolanda , Serrano-Aguilar Pedro 
Published: February 2021

Abstract
Background. Type 2 Diabetes Mellitus (T2DM) is one of the most prevalent health problems worldwide. Besides metabolic and cardiovascular complications, nearly one in four patients with T2DM suffer from comorbid depression and it has been reported higher incidence and prevalence of anxiety disorders. Beyond metabolic and cardiovascular risk improvement, empowering patients could contribute to mental health and quality of life enhancement. This Systematic Review (SR) aims to analyze and synthetize the evidence about the effect of patient empowerment on anxiety, depression and health-related quality of life (HRQOL).Methods. A SR of the literature will be conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines. The review will include studies reporting the effect of patient empowerment on anxiety, depression or HRQOL in patients with a T2DM diagnosis. We will use the following databases: Medline, Embase, PsycInfo and Cochrane Library. Additionally, the database searches will be supplemented by searching through citations and references. Literature searches, identification of eligible studies, data extraction, and bias assessment will be undertaken independently by at least two researchers. All disagreements will be resolved by an independent third reviewer. If heterogeneity between studies is too high or it is not possible to conduct a meta-analysis, a narrative analysis of the study results will be provided.Discussion. Existing evidence suggest that empowerment-based strategies significantly improve knowledge, anxiety and depressive levels, self-care, and motivation; contributing to increase HRQOL in patients with T2DM. The results of this SR will provide a deeper understanding on the relationship between patient empowerment and psychosocial outcomes in T2DM.Systematic review registration: PROSPERO CRD42020192429.
Mentorship on malaria microscopy diagnostic service in Ethiopia: Baseline competency of microscopists and performance of health facilities
Authors: Gidey Bokretsion , Nega Desalegn , Abera Adugna , Abebe Abnet , Mekasha Sindew , Tasew Geremew , Haile Mebrahtom , Dillu Dereje , Mehari Degu , Assefa Ashenafi , Liknew Wondimeneh , G/tsadik Abeba , Mohammed Hussien , Woldie Ermias , Getachew Tsegaye , Ararso Desaelegn , Yenealem Dereje , Kebede Adisu , Etana Kebede , Kedida Gizachew , Solomon Hiwot , Tollera Getachew , Woyessa Adugna , Abate Ebba 
Published: February 2021

Abstract
Background: In Ethiopia, malaria cases are declining as a result of proven interventions and in 2017, the country launched a malaria elimination strategy in targeted settings. Accurate malaria diagnosis and prompt treatment are the key components of the strategy to prevent morbidity and stop the continuation of transmission. However, the quality of microscopic diagnosis in general is deteriorating as malaria burden declines. Therefore, this study was carried out to evaluate the competency of microscopists and the performance of health facilities on malaria microscopic diagnosis.Methods: A cross-sectional study was conducted from August 1st to September 30th, 2019 in nine regional states and one city administration. A standard checklist was used for on-site evaluation, archived patient slides were re-checked, and proficiency of microscopists was tested using WHO certified slides from the national slide bank at the Ethiopian Public Health Institute (EPHI). The strength of agreement, the sensitivity, the specificity, and the positive and negative predictive values were calculated.Results: In this study, 102 health facilities (84 health centers and 18 hospitals) were included; from which, 202 laboratory professionals participated. In slide re-checking, moderate agreement (Agreement: 76.0%; Kappa: 0.41) was observed between experts and microscopists on malaria detection in all health facilities. The sensitivity and specificity of routine slide reading and the re-checking results were 78.1% and 80.7%, respectively. Likewise, positive predictive value of 65.1% and negative predictive value of 88.8% were scored in the routine diagnosis. By panel testing, a substantial overall agreement (A: 91.8%; K: 0.79) was observed between microscopists and experts in detecting malaria parasites. The sensitivity and specificity in the detection of malaria parasites was 92.7% and 89.1%, respectively. Furthermore, in identifying species, a slight agreement (A: 57%; K: 0.18) was observed between microscopists and experts. Conclusion: The study found significant false positive and false negative results in routine microscopy on slide re-checking of Plasmodium parasites. Moreover, reduced grade in parasite species identification was reported on the panel tests. Therefore, implementing comprehensive malaria microscopy mentorship, in-service training, and supportive supervision are the key strategies to improve the overall performance of health facilities in malaria microscopy.
Increased aperiodic gamma power in young boys with Fragile X Syndrome is associated with better language ability
Authors: Wilkinson Carol , Nelson Charles A 
Published: February 2021

Abstract
Background: The lack of robust and reliable clinical biomarkers in Fragile X Syndrome (FXS), the most common inherited form of intellectual disability, has limited the successful translation of bench-to-bedside therapeutics. While numerous drugs have shown promise in reversing synaptic and behavioral phenotypes in mouse models of FXS, none have demonstrated clinical efficacy in humans. Electroencephalographic (EEG) measures have been identified as candidate biomarkers as EEG recordings of both adults with FXS and mouse models of FXS consistently exhibit alterations in resting state and task-related activity. However, the developmental timing of these EEG differences is not known as thus far EEG studies have not focused on young children with FXS. Further, understanding how EEG differences are associated with core symptoms of FXS is crucial to successful use of EEG as a biomarker, and may improve our understanding of the disorder. Methods: Resting-state EEG was collected from FXS boys with full mutation of Fmr1 (2.5-7 years old, n=11) and compared with both age-matched (n=12) and cognitive-matched (n=12) typically developing boys. Power spectra (including aperiodic and periodic components) were compared using non-parametric cluster-based permutation testing. Associations between 30-50Hz gamma power and cognitive, language, and behavioral measures were evaluated using Pearson correlation and linear regression with age as a covariate. Results: FXS participants showed increased power in the beta/gamma range (~25-50Hz) across multiple brain regions. Both a reduction in the aperiodic (1/f) slope and increase in beta/gamma periodic activity contributed to the significant increase in high-frequency power. Increased gamma power, driven by the aperiodic component, was associated with better language ability in the FXS group. No association was observed between gamma power and parent report measures of behavioral challenges, sensory hypersensitivities, or adaptive behaviors. Limitations: The study sample size was small, although comparable to other human studies in rare-genetic disorders. Findings are also limited to males in the age range studied. Conclusions: Resting-state EEG measures from this study in young boys with FXS identified similar increases in gamma power previously reported in adults and mouse models. The observed positive association between resting state aperiodic gamma power and language development supports hypotheses that alterations in some EEG measures may reflect ongoing compensatory mechanisms.
Trophic status, phytoplankton diversity, and water quality at Kafr El-Shinawy drinking-water treatment plant, Damietta
Authors: Deyab Mohamed , El-Adl Magda , Ward Fatma , Omar Eman 
Published: February 2021

Abstract
This work aims to study the seasonal fluctuation in physicochemical characteristics, trophic status, and some pollutants influencing phytoplankton diversity, and water quality at a compact Kafr El-Shinawy drinking-water treatment plant, Damietta – Egypt seasonally during 2018. Phytoplankton distribution was affected by the trophic status of water, level of pollutants, and physicochemical treatment processes of water. The predominance of phytoplankton species, especially Aphanizomenon flos aquae (Cyanophyta), Gomphosphaeria lacustris (Cyanophyta), Microcystis aeruginosa (Cyanophyta), Nostoc punctiforme (Cyanophyta), Oscillatoria limnetica (Cyanophyta), Pediastrum simplex (Chlorophyta), and Melosira granulata (Bacillariophyta) in treated water was much less than that in raw water. Trihalomethanes (THMs) levels in treated waters were higher than in raw water, while lower concentrations of heavy metals were recorded in treated water. Intracellular levels of microcystins were lower, whereas the extracellular levels were higher in treated water than raw water, and the former recorded the highest level in raw water during summer. Hence, the levels of dissolved microcystins and THMs in treated water were higher especially during summer, the season of luxurious growth of Microcystis species. Trophic state index (TSI) was relatively high in raw water compared with treated water due to high concentrations of nutrients (total-P, total-N, nitrite, nitrate, and ammonia) in raw water.
Synthesis, Molecular Docking, BSA, and In Vitro Reactivation Study of
Imidazopyridine Oximes Against Paraoxon Inhibited Acetylcholinesterase
Authors: Thakur Ashima , Patwa Jayant , Sharma Abha , Flora Swaran Jeet Singh 
Published: February 2021

Aim:
To synthesize and evaluate the fused heterocyclic imidazopyridine oxime as a reactivator against paraoxon inhibited acetylcholinesterase.

Background:
Organophosphorus compounds (OPs) include parathion, malathion, chlorpyrifos, monocrotophos, and diazinon which are commonly used in agriculture for enhancing agricultural productivity via killing crop-damaging pests. However, people may get exposed to OPs pesticides unintentionally/intentionally via ingestion, inhalation or dermal. The current treatment regimen includes reactivator such as mono or bis-pyridinium oximes along with anticholinergic and an anticonvulsant drugs are recommended for the treatment of OP poisoning. Unfortunately, the drawback of the existing reactivator is that owing to the permanent charge present on the pyridinium makes them inefficient to cross the blood-brain barrier (BBB) and reactivate OP-inhibited central nervous system (CNS) acetylcholinesterase. Therefore, there is a need of reactivator that could cross the BBB and reactivate the OP inhibited acetylcholinesterase.

Objective:
The objectives of the study were synthesis, molecular docking, BSA binding and in-vitro estimation of oximes of various substituted imidazo [1,2-a]pyridine against paraoxon inhibited acetylcholinesterase.

Method:
The reactivators were synthesized in three steps and characterized using various spectroscopic techniques. Molecular docking study was performed on 2WHP and 3ZLV PDB using Autodock tool. The acid dissociation constant (pKa) of oximes was calculated experimentally and drug-likeness properties of the oximes were calculated In silico using mole inspiration and Swiss ADME software. The binding of oximes with bovine serum albumin (BSA) was also investigated by UV-Vis spectrophotometer. The reactivation potential of the oximes was determined by in vitro enzymatic assay.

Result:
in-silico study inferred that synthesized molecules fulfilled the parameters that required for a successful CNS drug candidate. Further, in-vitro enzymatic assay indicated reasonable reactivation potential of the oximes against paraoxon-inhibited AChE. The binding of oximes with bovine serum albumin (BSA) revealed static quenching of intrinsic fluorescence of BSA by oxime. The binding constant value and number of binding sites were found 0.24 mol-1 and 1 respectively.

Conclusion:
The results of study concluded that this scaffold could be used for further designing of more efficient uncharged reactivators.
Reccomendations on Selecting The Topic of Student Thesis Concentration using Case Based Reasoning
Authors: Utami Annisaa , Suyanto Yohanes , Sihabuddin Agus 
Published: February 2021

Case Based Reasoning (CBR) is a method that aims to resolve a new case by adapting the solutions contained in previous cases that are similar to the new case. The system built in this study is the CBR system to make recommendations on the topic of student thesis concentration. This study used data from undergraduate students of Informatics Engineering IST AKPRIND Yogyakarta with a total of 115 data consisting of 80 training data and 35 test data. This study aims to design and build a Case Based Reasoning system using the Nearest Neighbor and Manhattan Distance Similarity Methods, and to compare the results of the accuracy value using the Nearest Neighbor Similarity and Manhattan Distance Similarity methods. The recommendation process is carried out by calculating the value of closeness or similarity between new cases and old cases stored on a case basis using the Nearest Neighbor Method and Manhattan Distance. The features used in this study consisted of GPA and course grades. The case taken is the case with the highest similarity value. If a case doesnt get a topic recommendation or is less than the trashold value of 0.8, a case revision will be carried out by an expert. Successfully revised cases are stored in the system to be made new knowledge. The test results using the Nearest Neighbor Method get an accuracy value of 97.14% and Manhattan Distance Method 94.29%.
Nocturnal Systolic Hypertension and Adverse Prognosis in Patients with CKD
Authors: Wang Qin , Wang Yu , Wang Jinwei , Zhang Luxia , Zhao Ming-Hui ,   the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)
Published: February 2021

Background and objectives
Nocturnal hypertension is associated with adverse outcomes in patients with CKD. However, the individual association of entities of nocturnal hypertension according to achievement of systolic and/or diastolic BP goals with kidney failure and cardiovascular outcomes of CKD is not clear.

Design, setting, participants, & measurements
Our study analyzed data from participants in the Chinese Cohort Study of Chronic Kidney Disease. Nocturnal hypertension was categorized into three entities: isolated nocturnal diastolic hypertension with diastolic BP ≥70 mm Hg and systolic BP <120 mm Hg, isolated nocturnal systolic hypertension with systolic BP ≥120 mm Hg and diastolic BP <70 mm Hg, and nocturnal systolic-diastolic hypertension with both systolic BP ≥120 mm Hg and diastolic BP ≥70 mm Hg. Associations of nocturnal hypertension entities with kidney failure and cardiovascular outcomes were evaluated by Cox regression.

Results
In total, 2024 patients with CKD stages 1–4 were included in our analysis (mean age, 49±14 years; 57% men; eGFR=51±29 ml/min per 1.73 m2; proteinuria: 0.9 [0.4–2.1] g/d). Among them, 1484 (73%) patients had nocturnal hypertension, with the proportions of 26%, 8%, and 66% for isolated nocturnal diastolic hypertension, isolated nocturnal systolic hypertension, and nocturnal systolic-diastolic hypertension, respectively. Three hundred twenty kidney events and 148 cardiovascular events were recorded during median follow-up intervals of 4.8 and 5.0 years for kidney and cardiovascular events, respectively. After adjustment, isolated nocturnal systolic hypertension was associated with a higher risk for cardiovascular events (hazard ratio, 3.17; 95% confidence interval, 1.61 to 6.23). Nocturnal systolic-diastolic hypertension showed a higher risk for both kidney failure (hazard ratio, 1.71; 95% confidence interval, 1.17 to 2.49) and cardiovascular outcomes (hazard ratio, 2.19; 95% confidence interval, 1.24 to 3.86). No association was observed between isolated nocturnal diastolic hypertension with either kidney failure or cardiovascular events.

Conclusions
Nocturnal systolic hypertension, either alone or in combination with diastolic hypertension, is associated with higher risks for adverse outcomes in patients with CKD.