bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photophysical study and in vitro approach against Leishmania panamensis of dicloro-5,10,15,20-tetrakis(4-bromophenyl)porphyrinato Sn(IV)
Authors: Espitia-Almeida Fabián , Diaz-Uribe Carlos , Vallejo William , Gómez-Camargo Doris , Romero Bohórquez Arnold R. , Linares-Flores Cristian 
Published: November 2021

Background:Photodynamic therapy activity against different biological systems has been reported for porphyrins. Porphyrin modifications through peripheral groups and/or by metal insertion inside the ring are main alternatives for the improvement of its photo-physical properties. In this study, we synthesized and characterized 5,10,15,20-tetrakis(4-bromophenyl)porphyrin and the dicloro-5,10,15,20-tetrakis(4-bromophenyl)porphyrinato Sn(IV).Methods:Metal-free porphyrin was synthesized using the Alder method, while the Sn(IV)-porphyrin complex was prepared by combining metal-free porphyrin with stannous chloride in DMF; the reaction yields were 47% and 64% respectively. Metal-free porphyrin was characterized by UV-Vis, FT-IR, ESI-mass spectrometry and13C-NMR. Additionally, the Sn(IV) -porphyrin complex was characterized using UV-Vis and FT-IR. Cyclic voltammetry tests in four different solvents. The fluorescence quantum yield (Φf) was measured using fluorescein as a standard, the singlet oxygen quantum yield (ΦD) was estimated using the standard 5,10,15,20-(tetraphenyl)porphyrin (H2TPP) and the quencher of singlet oxygen 1,3-diphenylisobenzofuran (DPBF).Results:UV-Vis assay showed typical Q and Soret bands for porphyrin and its metallo-porphyrin complex. Compounds showed photoluminescence at the visible range of electromagnetic spectrum. The inclusion of the metal in the porphyrin core changed the Φffrom 0.15 to 0.05 and the ΦDincreased from 0.55 to 0.59. Finally, the effect of the compounds on the viability ofL. panamensiswas evaluated by means of the MTT test. The results showed that both compounds decreased the viability of the parasite; this inhibitory activity was greater under light irradiation; the porphyrin compound had IC50of 16.5 μM and the Sn(IV)-porphyrin complex had IC50of 19.2 μM.Conclusion:The compounds were synthesized efficiently, their characterization was carried out by different spectroscopy techniques and their own signals were evidenced for both structures, both compounds decreased the cell viability ofL. panamensis.
Driver perceptions of advanced driver assistance systems: A case study
Authors: Abdul Razak Siti Fatimah , Yogarayan Sumendra , Azman Afizan , Abdullah Mohd Fikri Azli , Muhamad Amin Anang Hudaya , Salleh Mazrah 
Published: November 2021

Background: Automobile manufacturers need to have an insight and understand how consumers, specifically drivers, respond to the advanced driver assistance systems (ADAS) technology in their manufactured vehicles. This study reveals drivers’ perceptions of Malaysia’s advanced driver assistance systems, which is currently lacking in the literature. So far, other studies have focused on countries that are unlike Malaysia’s multi-culture environment. Methods: A survey was designed and distributed using convenience sampling to obtain responses from licensed drivers. Questions included demographic and driving questions, the perceptions of benefits and obstacles relevant to ADAS use, vehicle decision-making, and technology use. Data were collected from 818 respondents who were licensed drivers in Malaysia. Results were then analysed using statistical approaches. Results: The findings indicated that 76.8% of drivers have a positive attitude towards ADAS technology, particularly safety applications when they are available. Regardless of the accuracy of these systems, acceptance of the technology may shift upon viewing or hearing messages of possible problems with ADAS. Conclusions: It can be concluded that the safety advantages of ADAS technology are less valued by drivers who do not have experience of road traffic accidents. Furthermore, acceptance of the technology could be undermined by assuming that the safety applications could be compromised.
The hidden financial burden of healthcare: a systematic literature review of informal payments in Sub-Saharan Africa
Authors: Kabia Evelyn , Goodman Catherine , Balabanova Dina , Muraya Kui , Molyneux Sassy , Barasa Edwine 
Published: November 2021

Background: Informal payments limit equitable access to healthcare. Despite being a common phenomenon, there is a need for an in-depth analysis of informal charging practices in the Sub-Saharan Africa (SSA) context. We conducted a systematic literature review to synthesize existing evidence on the prevalence, characteristics, associated factors, and impact of informal payments in SSA. Methods: We searched for literature on PubMed, African Index Medicus, Directory of Open Access Journals, and Google Scholar databases and relevant organizational websites. We included empirical studies on informal payments conducted in SSA regardless of the study design and year of publication and excluded reviews, editorials, and conference presentations. Framework analysis was conducted, and the review findings were synthesized. Results: A total of 1700 articles were retrieved, of which 23 were included in the review. Several studies ranging from large-scale nationally representative surveys to in-depth qualitative studies have shown that informal payments are prevalent in SSA regardless of the health service, facility level, and sector. Informal payments were initiated mostly by health workers compared to patients and they were largely made in cash rather than in kind. Patients made informal payments to access services, skip queues, receive higher quality of care, and express gratitude. The poor and people who were unaware of service charges, were more likely to pay informally. Supply-side factors associated with informal payments included low and irregular health worker salaries, weak accountability mechanisms, and perceptions of widespread corruption in the public sector. Informal payments limited access especially among the poor and the inability to pay was associated with delayed or forgone care and provision of lower-quality care. Conclusions: Addressing informal payments in SSA requires a multifaceted approach. Potential strategies include enhancing patient awareness of service fees, revisiting health worker incentives, strengthening accountability mechanisms, and increasing government spending on health.
On the Overlap Between Everything and Nothing
Authors: Carrara Massimiliano , Mancini Filippo , Smid Jeroen 
Published: November 2021

Graham Priest has recently proposed a solution to the problem of the One and the Many which involves inconsistent objects and a non-transitive identity relation. We show that his solution entails either that the object everything is identical with the object nothing or that they are mutual parts; depending on whether Priest goes for an extensional or a non-extensional mereology.
Frenemies: Corporate Advertising Under Common Ownership
Authors: Lu Ruichang , Shen Qiaowei , Wang Tenghui , Zhang Xiaojun 
Published: November 2021

In this paper, we investigate the impact of ownership structure on corporate advertising expenditures. Using mutual fund mergers as an exogenous shock to ownership structure, we find that competing firms owned by the same institutional blockholders experience a significant reduction in advertising expenditure. The reduction in advertising expenditure is more likely to occur in the presence of higher coordination benefits or lower coordination costs. Specifically, this effect is more pronounced for firms in more competitive industries, in higher advertising-intensity industries, with greater common ownership, with more concentrated institutional ownership, and with headquarters located in the same state. Overall, our empirical evidence indicates that ownership by common institutional investors significantly affects corporate advertising strategy. This paper was accepted by Matthew Shum, marketing.
The Value of Price Discrimination in Large Social Networks
Authors: Huang Jiali , Mani Ankur , Wang Zizhuo 
Published: November 2021

We study the value of price discrimination in large social networks. Recent trends in industry suggest that, increasingly, firms are using information about social network to offer personalized prices to individuals based upon their positions in the social network. In the presence of positive network externalities, firms aim to increase their profits by offering discounts to influential individuals that can stimulate consumption by other individuals at a higher price. However, the lack of transparency in discriminative pricing may reduce consumer satisfaction and create mistrust. Recent research focuses on the computation of optimal prices in deterministic networks under positive externalities. We want to answer the question of how valuable such discriminative pricing is. We find, surprisingly, that the value of such pricing policies (increase in profits resulting from price discrimination) in very large random networks are often not significant. Particularly, for Erdös–Renyi random networks, we provide the exact rates at which this value decays in the size of the networks for different ranges of network densities. Our results show that there is a nonnegligible value of price discrimination for a small class of moderate-sized Erdös–Renyi random networks. We also present a framework to obtain bounds on the value of price discrimination for random networks with general degree distributions and apply the framework to obtain bounds on the value of price discrimination in power-law networks. Our numerical experiments demonstrate our results and suggest that our results are robust to changes in the model of network externalities. This paper was accepted by Gabriel Weintraub, revenue management and market analytics.
Bankrupt Innovative Firms
Authors: Ma Song , Tong Joy Tianjiao , Wang Wei 
Published: November 2021

We study how innovative firms manage their innovation portfolios after filing for Chapter 11 reorganization using three decades of data. We find that they sell off core (i.e., technologically critical and valuable), rather than peripheral, patents in bankruptcy. The selling pattern is driven almost entirely by firms with greater use of secured debt, and the mechanism is secured creditors exercising their control rights on collateralized patents. Creditor-driven patent sales in bankruptcy have implications for technology diffusion—the sold patents diffuse more slowly under new ownership and are more likely to be purchased by patent trolls.This paper was accepted by Gustavo Manso, finance.
Twist phase and classical entanglement of partially coherent light
Authors: Ponomarenko Sergey A. 
Published: November 2021

We demonstrate that the presence of a twist phase in a random light beam leads to classical entanglement between phase space degrees of freedom of the beam. We find analytically the bi-orthogonal decomposition of the Wigner function of a twisted Gaussian Schell-model (TGSM) source and quantify its entanglement by evaluating the Schmidt number of the decomposition. We show that (i) classical entanglement of a TGSM source vanishes concurrently with the twist in the fully coherent limit and (ii) entanglement dramatically increases as the source coherence level decreases. We also show that the discovered type of classical entanglement of a Gaussian Wigner function does not degrade on beam propagation in free space.
Effect of decision to delivery interval on perinatal outcomes during emergency cesarean deliveries in Ethiopia: A prospective cohort study
Authors: Kitaw Tebabere Moltot , Tsegaw Taye Birhan , Tadese Mesfin , Getaneh Temesgen 
Published: November 2021

BackgroundThe National guidelines of most developed countries suggest a target of 30 minutes of the decision to delivery interval for emergency cesarean section. Such guidelines may not be feasible in poorly resourced countries and busy obstetric settings. It is generally accepted that the decision to delivery interval should be kept to the minimum time achievable to prevent adverse outcomes. Therefore, this study aimed to determine the average decision to delivery interval and its effect on perinatal outcomes in emergency cesarean section.MethodsA prospective cohort study was conducted from May to July 2020 at Bahir Dar City Public Hospitals. A total of 182 participants were enrolled, and data were collected using a structured and pre-tested questionnaire. A systematic sampling technique was applied to select the study subjects. Data were cleaned and entered into Epi-Data version 4.6 and exported to SPSS version 25 software for analysis. Logistic regression analysis was performed to identify predictors of outcome variables, and variables with a p-value of <0.05 were considered statistically significant.ResultsThe average decision to delivery interval was 43.73 ±10.55 minutes. Anesthesia time [AOR = 2.1, 95%CI = (1.3–8.4)], and category of emergency cesarean section [AOR = 3, 95% CI = (2.1–11.5)] were predictors of decision to delivery interval. The prolonged decision to delivery interval had a statistically significant association with composite adverse perinatal outcomes (odds ratio [OR] = 1.8, 95% confidence interval [CI] = (1.2–6.5).ConclusionThe average decision to delivery interval was longer than the recommended time. It should always be considered an important factor contributing to perinatal outcomes. Therefore, to prevent neonatal morbidity and mortality, a time-dependent action is needed.
Trends in cardiovascular risk factors and treatment goals in patients with diabetes in Singapore-analysis of the SingHealth Diabetes Registry
Authors: Feng Liang , Lam Amanda , Carmody David , Lim Ching Wee , Tan Gilbert , Goh Su-Yen , Bee Yong Mong , Jafar Tazeen H. 
Published: November 2021

BackgroundAsian populations are at high risk of diabetes and related vascular complications. We examined risk factor control, preventive care, and disparities in these trends among adults with diabetes in Singapore.MethodsThe sample included 209,930 adults with diabetes aged≥18 years from a multi-institutional SingHealth Diabetes Registry between 2013 and 2019 in Singapore. We performed logistic generalized estimating equations (GEEs) regression analysis and used linear mixed effect modeling to evaluate the temporal trends.ResultsBetween 2013 and 2019, the unadjusted control rates of glycated hemoglobin (4.8%, 95%CI (4.4 to 5.1) and low-density lipoprotein cholesterol (LDL-C) (11.5%, 95%CI (11.1 to 11.8)) improved, but blood pressure (BP) control worsened (systolic BP (SBP)/diastolic BP (DBP) <140/90 mmHg: -6.6%, 95%CI (-7.0 to -6.2)). These trends persisted after accounting for the demographics including age, gender, ethnicity, and housing type. The 10-year adjusted risk for coronary heart disease (CHD) (3.4%, 95% (3.3 to 3.5)) and stroke (10.4%, 95% CI (10.3 to 10.5)) increased. In 2019, the control rates of glycated hemoglobin, BP (SBP/DBP<140/90 mmHg), LDL-C, each, and all three risk factors together, accounted for 51.5%, 67.7%, 72.2%, and 24.4%, respectively.ConclusionsTrends in risk factor control improved for glycated hemoglobin and LDL-C, but worsened for BP among diabetic adults in Singapore from 2013 to 2019. Control rates for all risk factors remain inadequate.
Long-term foot outcomes following differential abatement of inflammation and osteoclastogenesis for active Charcot neuroarthropathy in diabetes mellitus
Authors: Das Liza , Rastogi Ashu , Jude Edward B. , Prakash Mahesh , Dutta Pinaki , Bhansali Anil 
Published: November 2021

Aims
Inflammatory osteolysis is sine-qua-non of active Charcot neuroarthropathy (CN) causing decreased foot bone mineral density (BMD) and fractures. We aimed to explore the effect of anti-inflammatory or anti-resorptive agents for effect on foot bone mineral content (BMC) and consequent long-term outcomes of foot deformities, fractures and amputation.

Methods
Forty-three patients with active CN (temperature difference >2°C from normal foot) were evaluated. Patients were off-loaded with total contact cast and randomized to receive either methylprednisolone (1gm) (group A), zoledronate (5mg) (group B) or placebo (100ml normal saline) (group C) once monthly infusion for three consecutive months. Change in foot BMC was assessed at 6 months or at remission and followed subsequently up to 4 years for the incidence of new-onset fracture, deformities, or CN recurrence.

Results
Thirty-six participants (24 male, 12 female) were randomized (11 in group A, 12 group B, 13 group C). The mean age was 57.7± 9.9 years, duration of diabetes 12.3± 5.8 years and symptom duration 6.5± 2.8 weeks. BMC increased by 36% with zoledronate (p = 0.02) but reduced by 13% with methylprednisolone (p = 0.03) and 9% (p = 0.09) with placebo at remission. There were no incident foot fractures, however, two patients sustained ulcers, and 3 had new-onset or worsening deformities and none required amputation during 3.36 ± 0.89 years of follow-up.

Conclusion
Bisphosphonate for active CN is associated with an increase in foot bone mineral content as compared to decrease with steroids or total contact cast but long-term outcomes of foot deformities, ulceration and amputation are similar.

Trial registration
ClinicalTrials.gov: NCT03289338.
Molecular chlamydia and gonorrhoea point of care tests implemented into routine practice: Systematic review and value proposition development
Authors: Fuller Sebastian S. , Clarke Eleanor , Harding-Esch Emma M. 
Published: November 2021

Background
Sexually Transmitted Infections, including Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT), continue to be a global health problem. Increased access to point-of-care-tests (POCTs) could help detect infection and lead to appropriate management of cases and contacts, reducing transmission and development of reproductive health sequelae. Yet diagnostics with good clinical effectiveness evidence can fail to be implemented into routine care. Here we assess values beyond clinical effectiveness for molecular CT/NG POCTs implemented across diverse routine practice settings.

Methods
We conducted a systematic review of peer-reviewed primary research and conference abstract publications in Medline and Embase reporting on molecular CT/NG POCT implementation in routine clinical practice until 16th February 2021. Results were extracted into EndNote software and initially screened by title and abstract by one author according to the inclusion and exclusion criteria. Articles that met the criteria, or were unclear, were included for full-text assessment by all authors. Results were synthesised to assess the tests against guidance criteria and develop a CT/NG POCT value proposition for multiple stakeholders and settings.

Findings
The systematic review search returned 440 articles; 28 were included overall. The Cepheid CT/NG GeneXpert was the only molecular CT/NG POCT implemented and evaluated in routine practice. It did not fulfil all test guidance criteria, however, studies of test implementation showed multiple values for test use across various healthcare settings and locations. Our value proposition highlights that the majority of values are setting-specific. Sexual health services and outreach services have the least overlap, with General Practice and other non-sexual health specialist services serving as a “bridge” between the two.

Conclusions
Those wishing to improve CT/NG diagnosis should be supported to identify the values most relevant to their settings and context, and prioritise implementation of tests that are most closely aligned with those values.
Bowel Ultrasound: a Non-invasive, Easy to Use Method to Predict the Need to Intensify Therapy in Inflammatory Bowel Disease Patients
Authors: Les Anda , Iacob Razvan , Saizu Roxana , Cotruta Bogdan , Saizu Adrian Ionut , Iacob Speranta , Gheorghe Liliana , Gheorghe Cristian 
Published: November 2021

Background and Aims: Bowel ultrasound (BU) is a non-invasive, inexpensive, widely available tool, valuable for inflammatory bowel disease (IBD) assessment. The aim of the present study was to investigate the clinical utility of BU to predict the need to intensify therapy in IBD patients.
Methods: One hundred seventeen IBD patients (89 Crohn’s disease, and 28 ulcerative colitis) diagnosis established at least 6 months before enrolment, undergoing maintenance therapy were prospectively included in the study. Bowel ultrasound investigated the following parameters: the bowel wall thickness (BWT), loss of wall stratification, the presence of the bowel wall Doppler signal, the visible lymph nodes, the mucosal hyperechoic spots, and the irregular external bowel wall. The patients were followed-up for 6 months, registering the need to escalate the treatment regimen. Subgroup analyses were conducted for patients requiring immediate treatment intensification (37 subjects), due to active disease at baseline and patients with subsequent treatment intensification, in the 6 months follow-up period (21 cases) in comparison to patients that required no therapeutic optimization (59).
Results: During the follow-up, 49.6% of patients needed treatment escalation. All the investigated BU variables were significantly associated with the main outcome. In the multivariate analysis, the mean BWT (p<0.0001), and the presence of the bowel wall Doppler signal (p=0.007) were independent predictors of the main outcome. For the subgroup analyses: mean BWT (p=0.0001) and the presence of the bowel wall Doppler signal (p=0.01) were independent predictors for immediate treatment intensification (active disease at baseline) and mean BWT (p=0.0003) and the lack of bowel wall stratification (p=0.05) were independent predictors for the need of subsequent therapeutic optimization. Logistic regression prediction models and prediction scores (BU score) had the best AUROC values (>0.91) when compared to traditional biomarkers of active inflammation, such as C reactive protein or fecal calprotectin.
Conclusion: Bowel ultrasound could be used as a non-invasive, easy to use diagnostic tool to predict the need to intensify therapy in patients with IBD.