bluuebunny/crossref_metadata_2025_split huggingface dataset:
A First Intercomparison of the Simulated LGM Carbon Results Within PMIP‐Carbon: Role of the Ocean Boundary Conditions
Authors: Lhardy F. , Bouttes N. , Roche D. M. , Abe‐Ouchi A. , Chase Z. , Crichton K. A. , Ilyina T. , Ivanovic R. , Jochum M. , Kageyama M. , Kobayashi H. , Liu B. , Menviel L. , Muglia J. , Nuterman R. , Oka A. , Vettoretti G. , Yamamoto A. 
Published: September 2021

AbstractModel intercomparison studies of coupled carbon‐climate simulations have the potential to improve our understanding of the processes explaining the drawdown at the Last Glacial Maximum (LGM) and to identify related model biases. Models participating in the Paleoclimate Modeling Intercomparison Project (PMIP) now frequently include the carbon cycle. The ongoing PMIP‐carbon project provides the first opportunity to conduct multimodel comparisons of simulated carbon content for the LGM time window. However, such a study remains challenging due to differing implementation of ocean boundary conditions (e.g., bathymetry and coastlines reflecting the low sea level) and to various associated adjustments of biogeochemical variables (i.e., alkalinity, nutrients, dissolved inorganic carbon). After assessing the ocean volume of PMIP models at the pre‐industrial and LGM, we investigate the impact of these modeling choices on the simulated carbon at the global scale, using both PMIP‐carbon model outputs and sensitivity tests with the iLOVECLIM model. We show that the carbon distribution in reservoirs is significantly affected by the choice of ocean boundary conditions in iLOVECLIM. In particular, our simulations demonstrate a GtC effect of an alkalinity adjustment on carbon sequestration in the ocean. Finally, we observe that PMIP‐carbon models with a freely evolving and no additional glacial mechanisms do not simulate the drawdown at the LGM (with concentrations as high as 313, 331, and 315 ppm), especially if they use a low ocean volume. Our findings suggest that great care should be taken on accounting for large bathymetry changes in models including the carbon cycle.
SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism
Authors: Jing Yukai , Luo Li , Chen Ying , Westerberg Lisa S. , Zhou Peng , Xu Zhiping , Herrada Andrés A. , Park Chan-Sik , Kubo Masato , Mei Heng , Hu Yu , Lee Pamela Pui-Wah , Zheng Bing , Sui Zhiwei , Xiao Wei , Gong Quan , Lu Zhongxin , Liu Chaohong 
Published: September 2021

AbstractThe SARS-CoV-2 infection causes severe immune disruption. However, it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients. In our study, we have characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation, but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation. However, the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation. Interestingly, we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients. Moreover, the BCR signaling and early B-cell response were disrupted upon BCR stimulation. Mechanistically, we found that the reduced CD19 expression was caused by the dysregulation of cell metabolism. In conclusion, we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism, which may provide a new intervention target to cure COVID-19.
Systems approaches identify the consequences of monosomy in somatic human cells
Authors: Chunduri Narendra Kumar , Menges Paul , Zhang Xiaoxiao , Wieland Angela , Gotsmann Vincent Leon , Mardin Balca R. , Buccitelli Christopher , Korbel Jan O. , Willmund Felix , Kschischo Maik , Raeschle Markus , Storchova Zuzana 
Published: September 2021

AbstractChromosome loss that results in monosomy is detrimental to viability, yet it is frequently observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient monosomic cell lines, we find that chromosome loss impairs proliferation and genomic stability. Transcriptome and proteome analysis demonstrates reduced expression of genes encoded on the monosomes, which is partially compensated in some cases. Monosomy also induces global changes in gene expression. Pathway enrichment analysis reveals that genes involved in ribosome biogenesis and translation are downregulated in all monosomic cells analyzed. Consistently, monosomies display defects in protein synthesis and ribosome assembly. We further show that monosomies are incompatible with p53 expression, likely due to defects in ribosome biogenesis. Accordingly, impaired ribosome biogenesis and p53 inactivation are associated with monosomy in cancer. Our systematic study of monosomy in human cells explains why monosomy is so detrimental and reveals the importance of p53 for monosomy occurrence in cancer.
Neutral bots probe political bias on social media
Authors: Chen Wen , Pacheco Diogo , Yang Kai-Cheng , Menczer Filippo 
Published: September 2021

AbstractSocial media platforms attempting to curb abuse and misinformation have been accused of political bias. We deploy neutral social bots who start following different news sources on Twitter, and track them to probe distinct biases emerging from platform mechanisms versus user interactions. We find no strong or consistent evidence of political bias in the news feed. Despite this, the news and information to which U.S. Twitter users are exposed depend strongly on the political leaning of their early connections. The interactions of conservative accounts are skewed toward the right, whereas liberal accounts are exposed to moderate content shifting their experience toward the political center. Partisan accounts, especially conservative ones, tend to receive more followers and follow more automated accounts. Conservative accounts also find themselves in denser communities and are exposed to more low-credibility content.
Quantum anomalous Hall edge channels survive up to the Curie temperature
Authors: Fijalkowski Kajetan M. , Liu Nan , Mandal Pankaj , Schreyeck Steffen , Brunner Karl , Gould Charles , Molenkamp Laurens W. 
Published: September 2021

AbstractAchieving metrological precision of quantum anomalous Hall resistance quantization at zero magnetic field so far remains limited to temperatures of the order of 20 mK, while the Curie temperature in the involved material is as high as 20 K. The reason for this discrepancy remains one of the biggest open questions surrounding the effect, and is the focus of this article. Here we show, through a careful analysis of the non-local voltages on a multi-terminal Corbino geometry, that the chiral edge channels continue to exist without applied magnetic field up to the Curie temperature of bulk ferromagnetism of the magnetic topological insulator, and that thermally activated bulk conductance is responsible for this quantization breakdown. Our results offer important insights on the nature of the topological protection of these edge channels, provide an encouraging sign for potential applications, and establish the multi-terminal Corbino geometry as a powerful tool for the study of edge channel transport in topological materials.
Chinese provincial multi-regional input-output database for 2012, 2015, and 2017
Authors: Zheng Heran , Bai Yangchun , Wei Wendong , Meng Jing , Zhang Zhengkai , Song Malin , Guan Dabo 
Published: September 2021

AbstractGlobal production fragmentation generates indirect socioeconomic and environmental impacts throughout its expanded supply chains. The multi-regional input-output model (MRIO) is a tool commonly used to trace the supply chain and understand spillover effects across regions, but often cannot be applied due to data unavailability, especially at the sub-national level. Here, we present MRIO tables for 2012, 2015, and 2017 for 31 provinces of mainland China in 42 economic sectors. We employ hybrid methods to construct the MRIO tables according to the available data for each year. The dataset is the consistent China MRIO table collection to reveal the evolution of regional supply chains in China’s recent economic transition. The dataset illustrates the consistent evolution of China’s regional supply chain and its economic structure before the 2018 US-Sino trade war. The dataset can be further applied as a benchmark in a wide range of in-depth studies of production and consumption structures across industries and regions.
Effect of fermentation time on the content of bioactive compounds with cosmetic and dermatological properties in Kombucha Yerba Mate extracts
Authors: Ziemlewska Aleksandra , Nizioł-Łukaszewska Zofia , Bujak Tomasz , Zagórska-Dziok Martyna , Wójciak Magdalena , Sowa Ireneusz 
Published: September 2021

AbstractKombucha is a beverage made by fermenting sugared tea using a symbiotic culture of bacteria belonging to the genus Acetobacter, Gluconobacter, and the yeasts of the genus Saccharomyces along with glucuronic acid, which has health-promoting properties. The paper presents the evaluation of ferments as a potential cosmetic raw material obtained from Yerba Mate after different fermentation times with the addition of Kombucha. Fermented and unfermented extracts were compared in terms of chemical composition and biological activity. The antioxidant potential of obtained ferments was analyzed by evaluating the scavenging of external and intracellular free radicals. Cytotoxicity was determined on keratinocyte and fibroblast cell lines, resulting in significant increase in cell viability for the ferments. The ferments, especially after 14 and 21 days of fermentation showed strong ability to inhibit (about 40% for F21) the activity of lipoxygenase, collagenase and elastase enzymes and long‐lasting hydration after their application on the skin. Moreover, active chemical compounds, including phenolic acids, xanthines and flavonoids were identified by HPLC/ESI–MS. The results showed that both the analyzed Yerba Mate extract and the ferments obtained with Kombucha may be valuable ingredients in cosmetic products.
The impact of prioritisation and dosing intervals on the effects of COVID-19 vaccination in Europe: an agent-based cohort model
Authors: Català Martí , Li Xintong , Prats Clara , Prieto-Alhambra Daniel 
Published: September 2021

AbstractDifferent strategies have been used to maximise the effect of COVID-19 vaccination campaigns in Europe. We modelled the impact of different prioritisation choices and dose intervals on infections, hospitalisations, mortality, and public health restrictions. An agent-based model was built to quantify the impact of different vaccination strategies over 6 months. Input parameters were derived from published phase 3 trials and official European figures. We explored the effect of prioritising vulnerable people, care-home staff and residents, versus contagious groups; and the impact of dose intervals ranging from 3 to 12 weeks. Prioritising vulnerable people, rather than the most contagious, led to higher numbers of COVID-19 infections, whilst reducing mortality, hospital admissions, and public health restrictions. At a realistic vaccination speed of ≤ 0·1% population/day, separating doses by 12 weeks (vs a baseline scenario of 3 weeks) reduced hospitalisations, mortality, and restrictions for vaccines with similar first- and second-dose efficacy (e.g., the Oxford-AstraZeneca and Moderna vaccines), but not for those with lower first vs second-dose efficacy (e.g., the Pfizer/BioNTech vaccine). Mass vaccination will dramatically reduce the effect of COVID-19 on Europe’s health and economy. Early vaccination of vulnerable populations will reduce mortality, hospitalisations, and public health restrictions compared to prioritisation of the most contagious people. The choice of interval between doses should be based on expected vaccine availability and first-dose efficacy, with 12-week intervals preferred over shorter intervals in most realistic scenarios.
Timing of hospital admission for stillbirth delivery on maternal and obstetric outcome: a retrospective cohort study
Authors: Muin Dana Anaïs , Scharrer Anke , Farr Alex , Kiss Herbert , Haslacher Helmuth 
Published: September 2021

AbstractThe effect of timing of hospital admission for stillbirth delivery following late intrauterine fetal death (IUFD) has not yet been described. By this study, we aimed to gain an understanding of the impact of “immediate” (i.e., on the same day of IUFD diagnosis) versus “delayed” hospital admission (i.e., on the subsequent day or two days after IUFD diagnosis) on maternal and delivery outcome parameters. This retrospective cohort study comprised all women who suffered a singleton IUFD ≥ 21 gestational weeks and delivered the stillborn at our tertiary referral center between 2003 and 2019. We excluded all terminations of pregnancy and women presenting with acute symptoms on the day of IUFD diagnosis. In total, 183 women were included of whom 69.4% (n = 127) were immediately admitted and 30.6% (n = 56) had delayed admission. Median gestational age of IUFD was 30+3 (21+0–41+3) weeks. Whilst women with early signs of labor were more frequently admitted immediately (87.5%; 14/16), neither maternal demographic and obstetric parameters, nor day of the week or presenting symptoms influenced the timing of hospital admission. 77.6% (142/183) of women after IUFD diagnosis delivered within the first 3 days after admission. Women after immediate admission equally often delivered on admission day and the day after (26.0%; 33/127 each), women after delayed admission most commonly delivered the day after admission (39.3%; 22/56). Stillbirth delivery on the day of diagnosis was more common upon immediate admission (p = 0.006), especially in early gestational weeks (p = 0.003) and with small fetal weight (p < 0.001), requiring less induction of labor. No significant difference regarding delivery mode, labor duration, use of intrapartum analgesia, need for episiotomy and risk of perineal injury was observed between the groups. Also rate of intrapartum hemorrhage was independent of admission timing, although immediately admitted women experienced greater median blood loss after vaginal delivery. Maternal laboratory parameters (hemoglobin, thrombocytes and CRP) were independent of admission timing, except for higher levels of leucocytes, neutrophils and lymphocytes in immediately admitted women. Our study shows no clinical superiority of immediate hospital admission for stillbirth delivery. Under stable medical circumstances, it, therefore, seems feasible to allow the woman delayed admission for labor and delivery.
Development of a novel approach for construction of high gradient braze-free S-band cavities
Authors: Aghayan Mahdi , Masoudi S. Farhad , Ghasemi Farshad , Wuensch Walter , Shaker Hamed 
Published: September 2021

AbstractVacuum breakdown is one of the main limitations to the operating accelerating gradient in radio frequency linear accelerators. Recent studies of copper cavities have been shown that harder copper conditions more quickly and can reach higher accelerating gradients than soft copper cavities. Exploiting this advantage requires the development of assembly methods that do not involve the copper-softening high-temperature heating cycles that are used in for example bonding and brazing. A shrink-fit method, which was already implemented successfully in the operation the IPM linac, is proposed for the construction high-gradient test S-band standing wave structure operating at 2998.5 MHz. The three cells cavity is designed to have a maximum gradient in the middle cell that is twice that of the adjacent cells. Mechanical considerations relating to the shrink-fit construction method have been performed using Ansys. To validate the simulations and ensure the feasibility of construction by shrink-fit method, a sample cavity was constructed and cold tests was performed.
Evolutionary study of maize dwarf mosaic virus using nearly complete genome sequences acquired by next-generation sequencing
Authors: Wijayasekara Dulanjani , Ali Akhtar 
Published: September 2021

AbstractNext-generation sequencing is a robust approach to sequence plant virus genomes in a very short amount of time compared to traditional sequencing methods. Maize dwarf mosaic virus (MDMV) is one of the most important plant viruses worldwide and a significant threat to maize production. In this study, we sequenced 19 MDMV isolates (10 from Johnsongrass and 9 from maize) collected in Oklahoma and Missouri during 2017–2019 using Illumina sequencing and determined the genetic diversity. Sequence reads were assembled and 19 nearly complete genome sequences of MDMV isolates were obtained. Phylogenetic analysis based on complete genomes nucleotide and amino acid sequences revealed two main clusters and a close evolutionary relationship among 19 MDMV isolates. Statistical analysis of individual genes for site-specific selection revealed that all genes are under negative selection. The fixation index (FST) analysis of the MDMV isolates revealed no gene flow between the two main phylogenetic clusters, which emphasizes the divergence of MDMV isolates from the USA. Among the USA MDMV isolates, the mean genetic distance (d) and nucleotide diversity ((π) were highest in the P1 gene coding region. This is the first detailed study on the evolutionary relationship of MDMV isolates based on the nearly complete genome analysis from maize and Johnsongrass.
Assessment of pancreatitis associated with tocilizumab use using the United States Food and Drug Administration Adverse Event Reporting System database
Authors: Kamath Ashwin , Acharya Sahana D. , Rao Rashmi R. , Ullal Sheetal D. 
Published: September 2021

AbstractTocilizumab (TCZ) is used to treat rheumatoid arthritis and other systemic inflammatory disorders. There is some evidence suggesting the occurrence of pancreatitis following TCZ use. We aimed to determine the reporting of pancreatitis following TCZ use in comparison with other drugs using the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database. We extracted adverse event reports submitted to FAERS during 2013–2019. A reporting odds ratio (ROR) with the lower bound 95% confidence interval (CI) > 1 and a lower limit of a two-sided 95% interval of information component (IC025) more than zero was considered significant. Following deduplication, 3,383,910 adverse event reports were available; 144 (0.004%) reports were of pancreatic adverse events associated with TCZ use, and 15,907 (0.47%) associated with other drugs. Of the 144 cases, 74 (51.39%) received concomitant medications with pancreatotoxic potential. The likelihood of reporting of pancreatic events, compared with any other adverse event, with TCZ use was 1.32 times higher than that with other drugs. The lower bound of the 95% CI of the ROR and IC remained above the criteria of significance throughout the study period, except 2013. The findings suggest disproportionately high reporting of pancreatitis in patients receiving TCZ as compared with other drugs. This marginally high reporting is not likely to be of immediate clinical concern and needs to be interpreted cautiously.
The association of low body mass index with neonatal morbidities in preterm infants
Authors: Lee Byoung Kook , Lee Jun Hyeok , Shin Jeongmin , Jung Young Hwa , Choi Chang Won 
Published: September 2021

AbstractLittle is known about the association between body proportionality at birth and neonatal outcomes in preterm infants. Body mass index (BMI) is one of the weigh-for-length ratios that represent body proportionality. The objective of this study was to examine whether BMI at birth affects neonatal outcomes in preterm infants. We assessed 3115 preterm (< 30 weeks), very low birth weight (< 1500 g) infants born between January 2013 and December 2016 and registered in the Korean Neonatal Network database. Using gender-specific BMI for gestational age curves, z-scores of BMI at birth were calculated. Low-, normal-, and high-BMI were defined as BMI z-scores of less than − 1, from − 1 to 1, and greater than 1, respectively. Neonatal morbidities and mortality in low- and high-BMI groups were compared to those in normal-BMI group. The low-BMI group had an increased risk of bronchopulmonary dysplasia, bronchopulmonary dysplasia or death, and necrotizing enterocolitis after adjusting for baseline characteristics and the birth weight z-score. High-BMI group had comparable neonatal outcomes to those of normal-BMI group. Low BMI at birth was associated with an increased risk of bronchopulmonary dysplasia and necrotizing enterocolitis, whereas High BMI at birth was not associated with adverse neonatal outcomes.
The presurgical controlling nutritional status (CONUT) score is independently associated with severe peristomal skin disorders: a single-center retrospective cohort study
Authors: Shiraishi Takuya , Ogawa Hiroomi , Katayama Chika , Osone Katsuya , Okada Takuhisa , Katoh Ryuji , Sano Akihiko , Sakai Makoto , Sohda Makoto , Shirabe Ken , Saeki Hiroshi 
Published: September 2021

AbstractWhile nutritional interventions may potentially lower the risk of peristomal skin disorders (PSDs) and their exacerbation, no previous studies have evaluated the relationship between PSDs and nutritional status using the Controlling Nutritional Status (CONUT) score. The purpose of this study was to assess the impact of preoperative nutritional status on stoma health, and determine risk factors for postoperative PSDs, including severe PSDs. A retrospective analysis was performed of 116 consecutive patients with rectal cancer who underwent radical surgery with ileostomy or colostomy creation. PSDs were diagnosed in 32 patients (27.6%); including 10 cases (8.7%) that were defined as severe based on the ABCD-stoma score. Multivariable logistic regression showed that smoking (odds ratio [OR] 3.451, 95% confidence interval [CI] 1.240–9.607, p = 0.018) and ileostomy (OR 3.287, 95% CI 1.278–8.458, p = 0.014) were independent risk factors for PSDs. A separate multivariable logistic regression analysis of risk factors for severe PSDs, found that the only independent risk factor was the CONUT score (OR 10.040, 95% CI 1.191–84.651, p = 0.034). Severe PSDs are associated with preoperative nutritional disorders, as determined by the CONUT score. Furthermore, nutritional disorders may increase the severity of PSDs, regardless of the stoma type.
Integrated non-volatile plasmonic switches based on phase-change-materials and their application to plasmonic logic circuits
Authors: Ghosh Rajib Ratan , Dhawan Anuj 
Published: September 2021

AbstractIntegrated photonic devices or circuits that can execute both optical computation and optical data storage are considered as the building blocks for photonic computations beyond the von Neumann architecture. Here, we present non-volatile hybrid electro-optic plasmonic switches as well as novel architectures of non-volatile combinational and sequential logic circuits. The electro-optic switches consist of a plasmonic waveguide having a thin layer of a phase-change-material (PCM). The optical losses in the waveguide are controlled by changing the phase of the PCM from amorphous to crystalline and vice versa. The phase transition process in the PCM can be realized by electrical threshold switching or thermal conduction heating via external electrical heaters or the plasmonic waveguide metal itself as an integrated heater. We have demonstrated that all logic gates, a half adder circuit, as well as sequential circuits can be implemented using the plasmonic switches as the active elements. Moreover, the designs of the plasmonic switches and the logic operations show minimum extinction ratios greater than 20 dB, compact designs, low operating power, and high-speed operations. We combine photonics, plasmonics and electronics on the same platform to design an effective architecture for logic operations.