bluuebunny/crossref_metadata_2025_split huggingface dataset:
circ_0005962 functions as an oncogene to aggravate NSCLC progression
Authors: Zhang Zhihong , Shan Zhenxiu , Chen Rubin , Peng Xiaorong , Xu Bin , Xiao Liang , Zhang Guofei 
Published: July 2021

Abstract

Background
Non-small cell lung cancer (NSCLC) is a leading threat to human lives with high incidence and mortality. Circular RNAs were reported to play important roles in human cancers. The purpose of this study was to investigate the role of circ_0005962 and explore the underlying functional mechanisms.

Methods
The protein levels of Beclin 1, light chain3 (LC3-II/LC3-I), Pyruvate dehydrogenase kinase 4 (PDK4), Cleaved Caspase 3 (C-caspase 3), and proliferating cell nuclear antigen were examined using western blot analysis. Glycolysis was determined according to the levels of glucose consumption and lactate production. Xenograft model was constructed to investigate the role of circ_0005962 in vivo.

Result
circ_0005962 expressed with a high level in NSCLC tissues and cells. circ_0005962 knockdown inhibited proliferation, autophagy, and glycolysis but promoted apoptosis in NSCLC cells. miR-382-5p was targeted by circ_0005962, and its inhibition reversed the role of circ_0005962 knockdown. Besides, PDK4, a target of miR-382-5p, was regulated by circ_0005962 through miR-382-5p, and its overexpression abolished the effects of miR-382-5p reintroduction. circ_0005962 knockdown suppressed tumor growth in vivo.

Conclusion
circ_0005962 knockdown restrained cell proliferation, autophagy, and glycolysis but stimulated apoptosis through modulating the circ_0005962/miR-382-5p/PDK4 axis. Our study broadened the insights into understanding the mechanism of NSCLC progression.
Association between Tfh and PGA in children with Henoch–Schönlein purpura
Authors: Meihua Miao , Xiaozhong Li , Qin Wang , Yunfen Zhu , Yanyan Cui , Xunjun Shao 
Published: July 2021

Abstract

Objective
The aim of this study was to investigate the roles of follicular helper CD4+ T cells (Tfh) and serum anti-α-1,4-d-polygalacturonic acid (PGA) antibody in the pathogenesis of Henoch–Schönlein purpura (HSP).

Methods
ELISA was performed to determine serum PGA-IgA and PGA-IgG. Flow cytometry was utilized to determine the peripheral CD4+ CXCR5+ and CD4+ CXCR5+ ICOS+ Tfh cells. Real-time PCR was conducted to determine the expression of Bcl-6 gene. Then the change of Tfh cells was analyzed, together with the association with the anti-PGA antibody as well as the roles in the pathogenesis of HSP.

Results
Compared with the cases with acute respiratory infection and elective surgery, the proportion of CD4+ CXCR5+ and CD4+ CXCR5+ ICOS+ Tfh cells in the HSP group showed significant elevation (P < 0.001). A significant correlation was noticed between PGA-IgA and CD4+ CXCR5+ Tfh cells (r = 0.380 and P = 0.042) and CD4+ CXCR5+ ICOS+ Tfh cells (r = 0.906 and P < 0.001). The expression of Bcl-6 in the HSP group showed no statistical difference compared with that in the acute respiratory infection and the surgery control (P < 0.05).

Conclusion
Increased activity of Tfh cells, which is closely related to mucosal immunity, may be a major contributor in the elevation of PGA-IgA, and Tfh cells and PGA-IgA are closely related to the occurrence of HSP.
Can exchange transfusion be replaced by double-LED phototherapy?
Authors: Abe Shinya , Fujioka Kazumichi 
Published: July 2021

Abstract
Phototherapy is a conventional treatment for neonatal jaundice and widely considered as a safe procedure. Recent developments in light-emitting diode (LED) phototherapy devices have made more effective treatments possible. Exchange transfusion (ET) is typically applied for cases of refractory severe hyperbilirubinemia despite its risk of various complications. Since the therapeutic effect of phototherapy is correlated with its irradiance, ET may be avoided by performing phototherapy with higher irradiation. Recently, we adopted double-LED phototherapy as a bridging treatment to ET to treat a case of severe hyperbilirubinemia. In this case, the continual increase of bilirubin levels was suppressed immediately after its administration, and ET was not required. Throughout the treatment, no complications or increase in oxidative stress was observed. In addition, neurodevelopment was appropriate for the patient’s age at the 1-year follow-up, and no findings of kernicterus, including physical and magnetic resonance imaging findings, were observed. We hypothesized that double-LED phototherapy may be a good treatment strategy to replace ET for infants with severe hyperbilirubinemia; however, further investigations regarding safety issues including acute and long-term complications are needed before clinical adaptation.
Organotin(IV) selenate derivatives – Crystal structure of [{(Ph3Sn)2SeO4} ⋅ CH3OH]
n
Authors: Diallo Waly , Cattey Hélène , Plasseraud Laurent 
Published: July 2021

Abstract
Crystallization of [(Ph3Sn)2SeO4] ⋅ 1.5H2O in methanol leads to the formation of [{(Ph3Sn)2SeO4} ⋅ CH3OH]
n
(1) which constitutes a new specimen of organotin(IV) selenate derivatives. In the solid state, complex 1 is arranged in polymeric zig-zag chains, composed of alternating Ph3Sn and SeO4 groups. In addition, pendant Ph3Sn ⋅ CH3OH moieties are branched along chains according to a syndiotactic organization and via Sn-O-Se connections. From a supramolecular point of view, intermolecular hydrogen bonds established between the selenate groups (uncoordinated oxygen) and the hydroxyl functions (CH3OH) of the pendant groups link the chains together.
Influence of various procedures for the determination of flow curves on the predictive accuracy of numerical simulations for mechanical joining processes
Authors: Böhnke Max , Kappe Fabian , Bobbert Mathias , Meschut Gerson 
Published: July 2021

Abstract
The predictive quality of numerical simulations for mechanical joining processes depends on the implemented material model, especially regarding the plasticity of the joining parts. Therefore, experimental material characterization processes are conducted to determine the material properties of sheet metal and generate flow curves. In this regard, there are a number of procedures which are accompanied by varying experimental efforts. This paper presents various methods of determining flow curves for HCT590X as well as EN AW-6014, including varying specimen geometries and diverse hardening laws for extrapolation procedures. The flow curves thus generated are compared considering the variety of plastic strains occurring in mechanical joining processes. The material data generated are implemented in simulation models for the joining technologies, clinching and self-piercing riveting. The influence of the varied methods on the predictive accuracy of the simulation model is analysed. The evaluation of the differing flow curves is achieved by comparing the geometric formation of the joints and the required joining forces of the processes with experimentally investigated joints.
Innovative bond strength testing of tin-based alloys for sliding bearings on steel supports
Authors: Sürül Kenan , Beiss Paul , Akin Okan 
Published: July 2021

Abstract
Since the bonding strength of Babbit alloys to their steel support cannot be measured with Chalmers specimens according to DIN ISO 4386, part 2, if the layer is too thin, an alternative specimen constellation was developed which enables the measurement of the bonding strength of layers as thin as 0.5 mm. The new specimen geometry consists of two coaxially aligned steel cylinders of equal diameter which leave a gap between opposite faces. After pretreatment in a metallic immersion bath of tin or an alloy of tin with 50 wt.-% zinc, the Babbit alloy is poured into the gap. Then the bonded steel cylinders are tensile tested. The force at fracture is divided by the cylinder cross-section yielding the bonding strength. This configuration is termed the face tensile specimen and was successfully tested on three different Babbit alloys. Up to a layer thickness of 1.5 mm the face tensile specimen delivers bonding strength quite comparable to those achieved with Chalmers specimens. Face tensile specimens require less Babbit alloy and are less costly to manufacture.
Corrosion behavior of a new 25Cr-3Ni-7Mn-0.66 N duplex stainless steel in artificial seawater
Authors: Vongsilathai Songkran , Lothongkum Anchaleeporn Waritswat , Lothongkum Gobboon 
Published: July 2021

Abstract
A new duplex 25Cr-3Ni-7Mn-0.66 N alloy was prepared in a vacuum arc re-melting furnace and characterized by metallographic and EPMA methods. Its corrosion behavior was investigated by potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and a Mott-Schottky (M-S) analysis in artificial seawater at room temperature and compared with those of super and normal commercial duplex stainless steel (SDSS and DSS). No significant difference in the open circuit potentials and pitting potentials was observed. Its passive film current density lies between those of SDSS and DSS. This was confirmed by EIS analysis. A pit attack was observed on the δ-phase for all duplex samples, because the PREN16 of the δ-phase was lower than that of the γ-phase. From the Mott-Schottky analysis, the passive films were found to be composed of bi-layer structures, a p-type semiconductor inner layer, and a n-type semiconductor outer layer. The degree of defect as well as the effect of nitrogen in passive film layer are discussed with respect to the point defect model.
Microstructure and strain rate-dependent deformation behavior of PBF-EB Ti6Al4V lattice structures
Authors: Kotzem Daniel , Gerdes Lars , Walther Frank 
Published: July 2021

Abstract
Additive manufacturing techniques enable the fabrication of new lightweight components with tailored mechanical properties. Considering current application fields, components are often over-dimensioned since a lack of data regarding the mechanical properties under compression or tensile loading at high strain rates is present. In this work, the influence of various strain rates on the mechanical properties of electron beam powder bed fusion Ti6Al4V lattice structures was investigated. In order to capture the damage mechanisms that occurred, a single unit cell plane was considered. In terms of mechanical characterization, high-speed tensile tests at nominal strain rates from 0.025 to 250 s-1 were carried out. By the additional use of a high-speed camera system and subsequent digital image correlation, an investigation of material reactions during shortest test times was enabled. Based on the results, a positive strain rate dependency was identified for yield and ultimate tensile strength for both investigated lattice types. In detail, an increase in ultimate tensile strength of 16 % for BCC- and 20 % for F2CCZ-specimens could be detected.
Structural, electronic and thermodynamic investigation of Ag2GdSi, Ag2GdSn and Ag2Gd Pb Heusler alloys: First-principles calculations
Authors: Zoubir Mahdjoub Kheireddine , Fadila Belkharroubi , Keltoum Boudia , Ibrahim Ameri , Farah Blaha Lamia , Al-Douri Y. , Mohammed Ameri 
Published: July 2021

Abstract
The strcutral, electronic and thermodynamic proerties of Ag2GdSi, Ag2GdSn and Ag2GdPb Heusler alloys are investigated using first-principles calculations of density functional theory (DFT) through linearized augmented plane waves (FP-LAPW) implemented within Wien2k software package. Structural, electronic and thermodynamic investigations of Ag2GdSi, Ag2GdSn and Ag2GdPb Heusler alloys are performed. Moreover, details regarding the lattice parameters, bulk modulus and its pressure derivative, band structure and density of states are elaborated upon.
Application of an inventive problem solving approach for developing new generation vehicle crash boxes
Authors: Doruk Emre 
Published: July 2021

Abstract
In frontal crashes, the most important parts that absorb the kinetic energy of the vehicle by plastic deformation are impact absorbers. Efforts are underway to develop innovative impact absorbers to keep the impact of the accident on drivers and passengers to a minimum. The TRIZ (theory of inventive problem solving) approach was used in the product development process of an impact absorber. TRIZ is a creative and systematic problem-solving method that can be used for the development of the next generation of products and systems. TRIZ tools such as ideality, technical contradictions formulation, inventive principles, s-field analysis, and scientific effects were used to achieve ideal final results (IFR). The solutions obtained are evaluated in terms of applicability/ manufacturing, cost, lightweight and patentability. This study generated a new standardized solution in Turkey.
Hybrid Taguchi-Lévy flight distribution optimization algorithm for solving real-world design optimization problems
Authors: Yıldız Mustafa , Panagant Natee , Pholdee Nantiwat , Bureerat Sujin , Sait Sadiq M. , Rıza Yıldız Ali 
Published: July 2021

Abstract
The Lévy flight distribution optimization algorithm is a recently developed meta-heuristic. In this study, the Lévy flight distribution optimization algorithm and the Taguchi method are hybridized to solve the shape optimization problem, which is the final step in developing optimum structural components. The new method is termed the hybrid Lévy flight distribution and Taguchi (HLFD-T) algorithm. Geometric dimensions are used as design variables in the optimization, and the problem is aimed at mass minimization. The constraint in the problem is the maximum stress value. The well-known Kriging meta-modeling approach and a specifically developed hybrid approach have been coupled in this paper to find the component’s optimal geometry. The results show that the proposed hybrid algorithm (HLFD-T) has more robust features than the ant lion algorithm, the whale algorithm, and the Lévy flight distribution optimization algorithm for obtaining an optimal component geometry.
Optimization of constrained mechanical design problems using the equilibrium optimization algorithm
Authors: Abderazek Hammoudi , Riza Yildiz Ali , Sait Sadiq M. 
Published: July 2021

Abstract
In this work, the optimization of structural and mechanical problems is carried out using the equilibrium optimizer (EO), which is a recent physical-based algorithm.The the ten-bar planar truss structure, planetary gearbox, hydrostatic thrust bearing, and robot gripper mechanism problems are solved using the EO algorithm. The results achieved using the EO in solving these problems are compared with those of recent algorithms. The computational results show that EO yields better outcomes and competitive results that can also be applied for the other problems studied.
A novel hybrid water wave optimization algorithm for solving complex constrained engineering problems
Authors: Gürses Dildar , Pholdee Nantiwat , Bureerat Sujin , Sait Sadiq M. , Yıldız Ali Rıza 
Published: July 2021

Abstract
In this work, a new hybrid optimization algorithm (HWW-NM), which combines the Nelder-Mead local search algorithm with the water wave algorithm, is introduced to solve real-world engineering optimization problems. This paper is one of the first studies in which both the water wave algorithm and the HWW-NM are applied to processing parameters optimization for manufacturing processes. HWW-NM performance is measured using the cantilever beam problem. Additionally, a problem for milling manufacturing optimization is posed and solved to evaluate HWW-NM performance in real-world applications. The results reveal that HWW-NM is an attractive optimization approach for optimizing real-life problems.
Performance evaluation of artificial neural networks for identification of failure modes in composite plates
Authors: Balli Serkan , Sen Faruk 
Published: July 2021

Abstract
The aim of this work is to identify failure modes of double pinned sandwich composite plates by using artificial neural networks learning algorithms and then analyze their accuracies for identification. Mechanically pinned specimens with two serial pins/bolts for sandwich composite plates were used for recognition of failure modes which were obtained in previous experimental studies. In addition, the empirical data of the preceding work was determined with various geometric parameters for various applied preload moments. In this study, these geometric parameters and fastened/bolted joint forms were used for training by artificial neural networks. Consequently, ten different backpropagation training algorithms of artificial neural network were applied for classification by using one hundred data values containing three geometrical parameters. According to obtained results, it was seen that the Levenberg-Marquardt backpropagation training algorithm was the most successful algorithm with 93 % accuracy rate and it was appropriate for modeling of this problem. Additionally, performances of all backpropagation training algorithms were discussed taking into account accuracy and error ratios.
Optimization of electrohydraulic forming process parameters using the response surface methodology
Authors: Arun Prasath Balasubramanian , Ganesh Pasupathy , Shanmuga Sundaram Karibeeran 
Published: July 2021

Abstract
This work’s main objective is to determine the optimum process parameters in the electrohydraulic forming (EHF) of austenitic stainless steel AISI 304 of 0.25 mm thickness for macro and micro shape. A truncated cone with grooves in the apex is considered as macro-micro shape. The response surface methodology (RSM) was developed for process variables such as voltage and standoff distance to determine the optimum parameters. To validate the model, confirmation experiments have been conducted, i. e. for the optimum value of voltage (V) = 8.935 kV and standoff distance (SOD) = 40.60 mm, and from the experiments the forming depth predicted is 9.221 mm and depth from the experiments is 9.5 mm. The percentage deviation from the predicted and experimental forming depth is 3.025 %, an acceptable range of less than 5 % for the surface roughness, the predicted value is 0.2598 microns, and the experimentally measured value is 0.268. The percentage deviation is 3.156 % between the predicted and experimental values, an acceptable range of less than 5 %. This shows that the model is suitable for predicting both responses. The validation experiments also found that the sheet fills one of the grooves and partially fills the other, which shows the capability of the electrohydraulic forming process. Confirmation experiments have been conducted.
Experimental and numerical investigation of the thrust force and temperature generation during a drilling process
Authors: Kaplan Yavuz , Nalbant Muammer 
Published: July 2021

Abstract
Although advances have been made in manufacturing technology, a number of problems still exist in the drilling process due to the chip formation which occurs in a closed area. This situation results in unpredictable force, torque and temperature generation. This study investigated the machining parameters in the drilling process using a finite element method (FEM). In the numerical analysis, thrust force, torque and temperature were calculated by three-dimensional simulation. Drilling processes were carried out with twist drill bits at three different cutting speeds and three different feed rates. The numerical analysis results were verified by experimental studies. The results show that FEM is a good candidate for obtaining cutting forces and temperature generation in drilling process.
The potential of SERS as an AST methodology in clinical settings
Authors: Samek Ota , Bernatová Silvie , Dohnal Fadi 
Published: July 2021

Abstract
The ability to identify and characterize microorganisms from tiny sample volumes in a rapid and reliable way is the first and crucial step in the diagnostics of microbial infections. Ideal analytical techniques would require minimal and low-cost sample preparation, permit automatic analysis of many serial samples, and allow rapid classification of present microorganisms against a stable database. Current practice, however, is far from this ideal; a typical analytical procedure might require a few days. Delayed laboratory results might lead, for example, to progress/spread of the infection, more serious condition of the patient, even death, prescription of inappropriate antibiotics that could be ineffective against causative agents and may as well contribute to the emerging problem of drug resistance in microorganisms. Several studies confirmed that surface enhanced Raman scattering (SERS) is capable of a rapid identification and discrimination of biological samples including medically relevant bacteria. A typical spectrum contains a wealth of information indicative of the cellular content of nucleic acids, purine bases, proteins, carbohydrates, and lipids. Such a spectrum functions as a cellular ‘fingerprint’ and serves as a sensitive indicator of the physiological state of the cell which in turn enables to differentiate cell types, actual physiological states, nutrient conditions, and phenotype changes. Consequently, the focus of this review is on the SERS spectra of bacteria which result from secreted metabolic substances – the purine bases – which are a common feature in the label-free SERS research related to clinical diagnostics of pathogens. Here is the review of the current status of SERS applications on bacteria. A special attention is given to the efforts of profiling antimicrobial susceptibility at clinically relevant species, which in turn has a great potential for use in routine point-of-care (POC) tests. Thus, early and accurate infection disease management can be provided at the bedside or at remote care centres.
Language attitudes and identity building in the linguistic landscape of Montreal
Authors: Leimgruber Jakob R. E. , Fernández-Mallat Víctor 
Published: July 2021

Abstract
Few studies to date have considered the agency of readers in reinterpreting the cultural, historical, political, and social background of the linguistic landscape (LL; visible language in public space) and the ways in which individual and collective identities are discursively conceptualised through the LL. In this article, we present results from a study involving participants from three self-described sociolinguistic identities (Francophone, Anglophone, and Bilingual), reading signs found in the LL of Montreal. Using photographic prompts, we questioned participants about the probable location of signs, their languages, and the languages’ placement on monolingual (French or English) and bilingual (French–English) signs emanating from both governmental and private entities. Further discussions about their emotive responses to the signs presented and the possible responses of “others” reveal the relative degrees of importance attached to these linguistic elements in constructing, negotiating, and communicating various and (more) fluid sociolinguistic identities.
The exploration of deoxygenation reactions for alcohols and derivatives using earth-abundant reagents
Authors: Tian Miao , Liu Mingxin 
Published: July 2021

Abstract
In Earth matter evolution, the deoxygenation process plays a central role as plant and animal remains, which are composed by highly oxygenated molecules, were gradually deoxygenated into hydrocarbons to give fossil fuels deep in the Earth crust. The understanding of this process is becoming crucial to the entire world and to the sustainable development of mankind. This review provides a brief summary of the extensive deoxygenation research under mild, potentially sustainable conditions. We also summarize some challenges and opportunities for potential deoxygenation reactions in the future.