bluuebunny/crossref_metadata_2025_split huggingface dataset:
LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity
Authors: Zhang Bing , Yan Pengyi , Li Zixuan , Xiong Junhao , Geng Zilong , Wei Weiting , Zhang Yan , Wu Gengze , Zhuang Tao , Tian Xiao Yu , Liu Zhijie , Liu Junling , Sun Kun , Chen Alex F , Zhang Yu , Zeng Chunyu , Huang Yu 
Published: March 2021

Abstract
Cellular senescence is associated with pleiotropic essential physiopathological processes including aging and age-related diseases. The persistent DNA damage response (DDR) is a major stress leading to senescence, but the underlying molecular link remains elusive. Here, we identified La Ribonucleoprotein 7 (LARP7), a 7SK RNA binding protein, as a novel aging antagonist. DDR-mediated Ataxia Telangiectasia Mutated (ATM) activation triggered the extracellular shuttling and down regulation of LARP7, which dampened SIRT1 deacetylase activity, enhanced p53 and NF-κB transcriptional activity by augmenting their acetylation, and thereby accelerated cellular senescence. Deletion of LARP7 led to senescent cell accumulation and premature aging in rodent model. Furthermore, we show that this ATM-LARP7-SIRT1-p53/NF-κB senescence axis was active in vascular aging and atherogenesis, and preventing its activation substantially alleviated aging and atherogenesis. Together, this study identifies LARP7 as a gatekeeper for senescence, and the altered ATM-LARP7-SIRT1-p53/NF-κB pathway plays an important role in DDR-mediated cellular senescence and aging-related atherosclerosis.
A Case Report of Hepatocellular Carcinoma Derived from Rastelli Procedure-Related Congestive Liver Disease
Authors: Sakano Yoshihiro , Noda Takehiro , Kobayashi Shogo , Iwagami Yoshifumi , Yamada Daisaku , Tomimaru Yoshito , Akita Hirofumi , Gotoh Kunihito , Umeshita Koji , Doki Yuichiro , Eguchi Hidetoshi 
Published: March 2021

Abstract
[Background] The prognosis of congenital heart disease in children has improved, but late complications in adulthood are becoming an important problem. One late complication after congenital heart surgery is congestive liver disease, leading to liver cirrhosis and hepatocellular carcinoma (HCC). The Rastelli procedure is one of the surgical methods for transposition of the great arteries, and patients are thought have a low post-surgical risk of congestive hepatopathy by receiving re-intervention for right ventricular outflow tract obstruction.[Case presentation] We present the first case of HCC derived from Rastelli procedure-related congestive liver disease in a 41-year-old male. The patient underwent the Rastelli operation at 2 years of age and right ventricular outflow tract reconstruction at 10 and 35 years of age due to right ventricular outflow tract obstruction. At 41 years of age, a hepatic tumor was detected by computed tomography. Abdominal enhancing computed tomography revealed a partially hypervascular tumor in segment 2 in early phase and wash-out in late phase. The patient was diagnosed with HCC and underwent left lateral segmentectomy of the liver, splenectomy, and partial gastrectomy. The patient was discharged on the 28th postoperative day without postoperative complications. The resected tumor pathologically revealed moderately differentiated HCC and F3 liver fibrosis.[Conclusions] In the management of patients after the Rastelli operation, surveillance for congestive liver disease and HCC development is important, even if the patients have undergone right ventricular outflow tract reconstruction.
Safe Traffic Behaviors in High School Students: a Predictive Cross-sectional Study Based on the Theory of Planned Behavior
Authors: Ranaei Vahid , Hassani Laleh , Jahanlou Alireza Shahab , Roshanaei Ghodratollah , Rezapur-Shahkolai Forouzan 
Published: March 2021

Abstract
Background: Road traffic injuries are known as one of the leading causes of death of young people in the world. Therefore, the present study was conducted to investigating the effective factors on safe traffic behavior of high school students in Hamadan using the theory of planned behavior. Methods: The present study is a cross-sectional-analytical study. The population of this study was all high school male students in Hamadan in the academic year 2020, of which 414 were selected by stratified random sampling method. The data collection tool was a researcher-made questionnaire that was conducted and were confirmed its validity and reliability. Results: Findings from Spearman correlation analysis and multiple regression showed that there is a significant positive relationship between knowledge (p<0.001), attitudes towards behavior (p<0.001), subjective norms (p<0.001) and perceived behavioral control (p<0.001) with students' behavioral intention. Also, was significant the effect of perceived behavioral control (P <0.001) and behavioral intention (P <0.001) on traffic safety behavior. Conclusion: Based on the findings, it can be concluded that the theory of planned behavior can be useful in predicting safe traffic behaviors.
First Proof-of-concept Evaluation of the FUSION-X-US-II Prototype for the Performance of Automated Breast Ultrasound in Healthy Volunteers
Authors: Schaefgen Benedikt , Juskic Marija , Hertel Madeleine , Barr Richard G , Radicke Marcus , Stieber Anne , Hennings André , Riedel Fabian , Sohn Christof , Heil Joerg , Golatta Michael 
Published: March 2021

Abstract
Purpose: The FUSION-X-US-II prototype was developed to combine 3D-automated breast ultrasound (ABUS) and digital breast tomosynthesis in a single device without decompressing the breast. We evaluated the technical function, feasibility of the examination workflow, image quality, breast tissue coverage and patient comfort of the ABUS device of the new prototype. Methods: In this prospective feasibility study, the FUSION-X-US-II prototype was used to perform ABUS in 30 healthy volunteers without history of breast cancer. The ABUS images of the prototype were interpreted by a physician with specialization in breast diagnostics. Any detected lesions were measured and classified using BI-RADS® scores. Image quality was rated subjectively by the physician and coverage of the breast was measured. Patient comfort was evaluated by a questionnaire after the examination. Results: 106 scans were performed (61 x CC, 23 x ML, 22 x MLO) in 60 breasts. Image acquisition and processing by the prototype was fast and accurate. Breast coverage by ABUS was approximately 90.8%. 16 breast lesions (all benign, classified as BIRADS® 2) were identified. The examination was tolerated by all patients. Conclusion: The FUSION-X-US-II prototype allows a rapid ABUS scan with mostly high patient comfort. Technical developments resulted in an improvement of quality and coverage compared to previous prototype versions. The results are encouraging for a test of the prototype in a clinical setting in combination with tomosynthesis.
Miniaturized MIMO Antenna with Complementary Split Ring Resonators Loaded Superstrate for X-band Application
Authors: S Karthigaiveni , Pandeeswari R , S Deivalakshmi 
Published: March 2021

Abstract
An aperture coupled two element metamaterial (MTM) antenna suitable for multiple input multiple output (MIMO) applications in the frequency band of 7.525-9.1GHz is proposed. This three-layered structure utilizes a vertical array of rectangular complementary split ring resonators (CSRR) between the contiguously placed circular non-bianisotropic complementary split ring resonator (NBCSRR) radiating elements for enhancement of isolation. This antenna achieves a maximum of 47dB isolation through this MNG structure insertion in the frequency band for 0.11 λ0 separation of the two antenna elements. The proposed antenna achieves a fractional -10dB impedance bandwidth of 18.94% and has a peak gain of 8.15dB. The efficiency of the antenna is 84.14% and the envelope correlation coefficient is less than 0.03 in the operating band. The antenna is low profile with an overall size of 0.85 λ0 x 0.45 λ0 x 0.133 λ0 and is suitable for X-band military applications.
Pyriproxyfen-treated bednets reduce reproductive fitness and longevity of pyrethroid-resistant Anopheles gambiae under laboratory and field conditions
Authors: Grisales Nelson , Lees Rosemary S , Maas James , Morgan John C , Wangrawa Dimitri W , Guelbeogo Wamdaogo M , N’Fale Sagnon , Lindsay Steven W , McCall Philip J , Ranson Hilary 
Published: March 2021

Abstract
Background

The efficacy of insecticide treated nets (ITNs) containing the insect growth regulator pyriproxyfen (PPF) and pyrethroid insecticides (PPF-ITNs) is being assessed in clinical trials to determine whether they provide greater protection from malaria than standard pyrethroid-treated ITNs in areas where mosquitoes are resistant to pyrethroids. Understanding the entomological mode of action of this new ITN class will aide interpretation of the results from these trials.
Methods

Anopheles gambiae s.l. mosquitoes from a susceptible laboratory strain were exposed to PPF-treated netting 24 h, 6 h, and immediately prior to, or 24 h post blood feeding, and the impact on fecundity, fertility and longevity recorded. Pyrethroid-resistant populations were exposed to nets containing permethrin and PPF (PPF-ITNs) in cone bioassays and daily mortality recorded. Mosquitoes were also collected from inside houses pre- and post-distribution of PPF-ITNs in a clinical trial conduced in Burkina Faso; female An. gambiae s.l. were then assessed for fecundity and fertility.
Results

PPF exposure reduced the median adult lifespan of insecticide-susceptible mosquitoes by 4 to 5 days in all exposure times (p < 0.05) other than 6 h pre-bloodmeal and resulted almost complete lifelong sterilisation. The longevity of pyrethroid-resistant mosquitoes was also reduced by at least 5 days after exposure to PPF- ITNs compared to untreated nets but was unaffected by exposure to standard pyrethroid only ITNs. A total of 386 blood-fed or gravid An. gambiae s.l. females were collected from five villages between 1 and 12 months before distribution of PPF-ITNs. Of these mosquitoes, 75 % laid eggs and the remaining 25 % appeared to have normal ovaries upon dissection. In contrast, only 8.6 % of the 631 blood-fed or gravid An. gambiae s.l. collected post PPF-ITN distribution successfully oviposited; 276 (43.7%) did not oviposit but had apparently normal ovaries upon dissection, and 301 (47.7%) did not oviposit and had abnormal eggs upon dissection. Egg numbers were also significantly lower (average of 138/female prior distribution vs 85 post distribution, p < 0.05).
Conclusion

Exposure to a mixture of PPF and pyrethroids on netting shortens the lifespan mosquitoes and reduces reproductive output. Sterilisation of vectors lasted at least one year under operational conditions. Our findings suggest a longer effective lifespan of PPF-pyrethroid nets than reported previously.
The impact of the work environment of nurses on patients safety
Authors: MALINOWSKA-LIPIEŃ IWONA , Micek Agnieszka , Gabryś Teresa , Kózka Maria , Gajda Krzysztof , Gniadek Agnieszka , Brzostek Tomasz , Fletcher Jason , Squires Allison 
Published: March 2021

Abstract
Introduction. Numerous studies have found that organizational features connected with the work environment of nurses have a significant influence on patients' safety. Aim of research. To capture nurses’ opinions about patients' safety and discern relationships with work environment characteristics. Material and methods. This cross-sectional study surveyed 1,825 nurses. The research used questionnaire consisting of four parts: 1/covered The Practice Environment Scale of the Nursing Work Index (PES-NWI), 2/assessed the quality of nursing care and care safety, 3/ contained information on the most recent duty served by the nurses, 4/ captured social and demographic data of participants. Results. The research identified strong association between patient safety assessment and work environment of nurses in the aspect of employment adequacy, cooperation between nurses and doctors, support for nurses from the managing staff, the possibility to participate in the management as well as professional promotion of nurses employed in the hospital (p<0.001). Nurses rated patient safety higher when responsible for a smaller number of patients. Conclusions. Work environment factors such as proper staffing, good cooperation with doctors, support from the management, professional independence as well as a prospect of promotion determine provision of safety for patient according to nurses.
Comparison of Accommodation and Accommodative Micro-Fluctuation After Implantable Collamer Lens and LASIK Surgery for Myopia
Authors: Li Li , Zhang Bo , Wang Zheng 
Published: March 2021

Abstract
Background: To longitudinally analyze and compare the accommodative micro-fluctuation (MFs) and accommodative function between myopic patients after implantable collamer lens (ICL) implantation and laser in situ keratomileusis (LASIK).Methods: Patients with good corrected visual acuity (20/20 or better) that underwent ICL (V4c) and LASIK for myopic-correction (ranging from -3.50 to -8.50 D) were recruited. Refraction, amplitude of accommodation (AMP), accommodative lags, high-order aberrations (HOAs), and MFs were recorded before surgery and 1 and 3 months after surgery. The ACOMEREF automatic refractor was used to measure the high-frequency component (HFC) of the MFs, which suggested tension of the ciliary muscle.Results: The study comprised 120 eyes. At 3 months after surgery, the manifest refractive spherical equivalent of the ICL and LASIK groups were -0.11 and -0.09 D, respectively (p = 0.46). HFC values were significantly higher at 1 month (p = 0.03) and 3 months postoperatively (p = 0.03) in the ICL group compared to that in the LASIK group. The ocular HOAs of the ICL group was 1.08 ± 0.43 μm, which was lower than the LASIK group 1.45 ± 0.54 μm (p = 0.01). No significant differences in AMP and accommodative lags between groups were noted at 3 months postoperatively. There was a positive correlation between HFC and vault of the ICL lens (r2 = 0.14, p = 0.005). There were no correlations between HFC and HOAs and postoperative MRSE in the two groups (all p﹥0.05).Conclusions: The HFC increased significantly after ICL implantation compared to laser in situ keratomileusis for myopic correction, which indicated increased tension of the ciliary muscle, and had a positive correlation on the vault of the ICL lens; However, studies with longer follow-up time and more structural evaluation are needed.
Intraocular Pressure Elevation within Six Days After Vitreoretinal Surgery with Silicone Oil Injection for Rhegmatogenous Retinal Detachment
Authors: Zhang Xiaoyan , Hao Xiaofeng , Xie Like 
Published: March 2021

Abstract
Background: We investigated the incidence of and risk factors for intraocular pressure elevation within 6 days following pars plana vitrectomy with silicone oil injection for rhegmatogenous retinal detachment. Methods: We reviewed the records of 55 patients in whom pars plana vitrectomy with silicone oil injection was performed. The intraocular pressure was evaluated before surgery and 1 day, 3 days, and 6 days post-operatively. Results: Intraocular pressure elevation was found in 49% of eyes within 6 days after surgery. A long duration of rhegmatogenous retinal detachment was significantly associated with intraocular pressure elevation on day 1 after surgery. Presence of diabetes was significantly associated with intraocular pressure elevation at 3 days post-operation. Intraocular pressure elevation may occur 6 days following topical steroid use. Conclusions: Intraocular pressure should be monitored regularly in the early post-operative period after pars plana vitrectomy with silicone oil injection for rhegmatogenous retinal detachment, especially in patients with prolonged detachment and diabetic history.
Associations Between Structural and Social Determinants of Health With COVID Infection Rates at a Safety Net Hospital.
Authors: Ogunyemi Dotun , Mantilla Rolando , Markus Abhinav , Reeves Aubrey , Win Suyee , Barrientos Devin Ryan , Lim Dandrich , Raval Niren , Lanum David 
Published: March 2021

Abstract
Background: The reported disproportionate impact of COVID-19 infections on minority populations may be due to living in disinvested communities with high level of poverty, pollution, inadequate unsafe employment, and overcrowded housing.Objective: To determine the association of county, city, and individual risk factors with COVID-19 infection ratesMethods: Retrospective chart review on COVID-19 tests performed from March through July 2020 at Arrowhead Regional Medical Center, Colton­, California. Results: A total of 7104 tests were performed with 69% in the drive-through testing center. The mean duration of test-to-results time was 2.36 (+0.02) days. COVID-19 positive tests occurred in 1095 (15.4%). At least one symptom occurred in 414 (33%) with sensitivity of 37.8, specificity of 86.02, positive predictive value of 33.01, and negative predictive value of 72.76. Individual factors significantly associated with testing positive for COVID-19 were diabetes, Hispanic ethnicity, and male gender. Younger age was significantly associated with testing COVID positive with the highest risk in children <10 years. COVID-19 positive persons significantly resided in cities with higher population density, household members, poverty, non-English speaking homes, disability, lower median household income, lack of health insurance and decreased access to a computer and WIFI services. County health rankings showed significant positive association between testing positive for COVID-19 with increased smoking, air pollution, violent crimes, physical inactivity, decreased education and access to exercise. Conclusion: Adverse county health rankings; socially and economically disadvantaged cities are associated with an increased risk of testing positive for COVD-19. This information can be used in strategic planning and invention mitigation.
Free-standing nanopaper electrode for all-printed super-flexible perovskite solar cells
Authors: Vasilopoulou Maria , da Silva Wilson Jose , Kim Hyeong Pil , Carnio Brett Nathan , Ahvazi Behzad , Noh Mohamad Firdaus Mohamad , Soh Mohd Fairuz , Elezzabi Abdulhakem Youssef , Schneider Fabip , Teridi Mohd Asri Mat , Soultati Anastasia , Argitis Panagiotis , Davazoglou Dimitris , Jang Jin , Mcculloch Iain , Gasparini Nicola , Yusoff Abd. Rashid Mohd , Nazeeruddin Mohammad Khaja 
Published: March 2021

Abstract
The development of all-printed, flexible solar cells of high efficiency and ultra-low weight will offer advancements for new market entrants. Herein, we report the design and fabrication of all-printed in ambient air, super-flexible perovskite solar cells with approaching 20% power conversion efficiency and extremely low weight of 5.1 g m-2 leading to an unprecedented power-to-weight ratio of 38,470 W Kg-1. This performance advance was achieved through the design of a highly transparent and conducting nanopaper used as a free-standing bottom electrode (FSBE). The FSBE consisted of cellulose nanocrystals grafted with semi-metallic super-reduced polyoxometalate clusters that enabled high conductivities up to 18 S cm-1 combined with transparency >96%. It also acted as a conformal barrier preventing performance loss upon heating at 95 oC under continuous illumination in inert environment; and strong resistance to decomposition when immersed in a mild citric acid water solution for 100 days, which we further exploit to demonstrate full device recyclability. The inherent flexibility of cellulose nanocrystals enabled remarkable flexibility of these cells under 2,000 repeated bending and folding cycles and mechanical strength upon extensive strain up to 20%. Notably, the nanopaper remained unaffected for strains up to 60%. These findings open the door for efficient and lightweight solar cells with a low environmental impact.
Interaction between overweight, obesity and smoking on the risk of pre-diabetes and type 2 diabetes in Guangdong, China
Authors: Zeng Zhuanping , Jin Yinghua , Zheng Yingying , Xiang Lei , Yang Jin , Peng Liufen , Wei Qin , Yang Meng , Cheng Qiuting , Rong Xianglu , Piao Shenghua , Guo Jiao 
Published: March 2021

Abstract
Background

Pre-diabetes mellitus (PDM) is considered an early warning signal of type 2 diabetes mellitus (T2DM). However, most studies only analyze the risk factors of diabetes, ignore the exploration of PDM. The aim of this study was to investigate the independent and combined impacts of overweight obesity and smoking on the risk of PDM and T2DM.
Methods

28,208 patients with T2DM were selected from 5 cities in the Pearl River Delta, Guangdong Province, China. According to the same region, gender and age difference less than 5 years old, 28208 patients with PDM and 28208 patients with normal glucose tolerance (NGT) were randomly selected. We analyzed the influential factors of PDM,T2DM and the interaction between smoking and overweight and obesity on using ordered multi-class logistic regression and multi-class results non-conditional logistic regression.
Results

Overweight and obesity (OR = 1.427,95%CI:1.388 ~ 1.468; OR = 1.829,95%CI:1.753 ~ 1.908) and smoking (OR = 1.161,95%CI:1.113 ~ 1.212) were risk factors for the onset of T2DM by ordered multiple Logistic regression. Furthermore, both in the comparison of NGT, PDM and NGT, T2DM, the results showed that overweight, obesity and smoking were risk factors for both PDM and T2DM too. And we found there was an additive interaction between overweight obesity and smoking in the developing of T2DM. Moreover, there would be 0.196(0.051 ~ 0.341) relative excess risk due to the additive interaction, 9.1% (2.0%-16.1%) of T2DM exposed to both risk factors was attributable to the additive interaction, and the risk of T2DM in overweight and obese smokers was 1.203(1.004–1.402) times as high as the sum of risks in the participants exposed to a single risk factor alone too.
Conclusions

Overweight obesity and smoking are the risk factors for the onset of T2DM. The risk of the coexistence of both factors is greater than that of single factors. Early weight control and positive smoking control are beneficial to prevent and delay the occurrence of T2DM.
SERCA2a related miRNA miR-140-3p as a potential biomarker for chronic heart failure
Authors: Wu Wei-Yin , Ye Tao , Qiang Hai-Feng , Zhou Xiao-Xia , Li Gang 
Published: March 2021

Abstract
Background

Multiple miRNAs were reported to be associated with sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) in mediating the process of heart failure. However, whether these miRNAs are relevant to chronic heart failure (CHF) is rarely reported.
Methods

This study was designed to explore a new biomarker from the SERCA2a related candidate miRNAs for CHF. A total of 195 blood samples from 84 CHF patients, 86 non-heart failure patients and 25 healthy subjects were collected. The circulating expression of SERCA2a related candidate miRNAs (let-7a-5p, miR-24-3p, miR-25-3p, miR-133a-3p, miR-137a-3p, miR-140-3p, miR-141-3p, miR-142-3p, miR-148a-3p, and miR-153-3p) were detected with qRT-PCR. The area under curve value, correlations between miRNAs and NT-proBNP were applied to determine the relationship between CHF and the candidate miRNAs.
Results

The results showed among the 10 candidate miRNAs, only let-7a-5p, miR-25-3p, and miR-140-3p were significantly increased of CHF patients. However, only miR-140-3p showed the high area under the curve (AUC) value (ROC = 0.8873) and strong positive correlations (r = 0.5113) between miR-140-3p levels and NT-proBNP concentration. The level of miR-140-3p in LVEF < 45% of CHF patients was higher than in LVEF > 45%. However, there was no significant difference between hypertension and non-hypertension of the levels of miR-140-3p in CHF patients. Interestingly, the level of miR-140-3p was higher in NYHA IV CHF patients than in NYHA II or III. More important, the miR-140-3p level also declined when the heart function of NYHA IV patients was improved after treatment.
Conclusions

These results indicated circulation levels of miR-140-3p is related to the severity of chronic heart failure, and miR-140-3p may be an important biomarker for heart failure with reduced ejection fraction.