bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revealing the nature of the transient source MAXI J0637-430 through spectro-temporal analysis
Authors: Baby Blessy E , Bhuvana G R , Radhika D , Katoch Tilak , Mandal Samir , Nandi Anuj 
Published: September 2021

ABSTRACT
We study the spectral and temporal properties of MAXI J0637-430 during its 2019–2020 outburst using Neutron Star Interior Composition Explorer (NICER), AstroSat , and Swift–XRT data. The source was in a disc dominant state within a day of its detection and traces out a ‘c’ shaped profile in the HID, similar to the ‘mini’-outbursts of the recurrent BHB 4U 1630-472. Energy spectrum is obtained in the 0.5−10 keV band with NICER and Swift–XRT, and 0.5−25 keV with AstroSat. The spectra can be modelled using a multicolour disc emission (DISKBB) convolved with a thermal Comptonization component (thcomp). The disc temperature decreases from 0.6 to 0.1 keV during the decay with a corresponding decrease in photon index (Γ) from 4.6 to 1.8. The fraction of Compton-scattered photons (fcov) remains &lt;0.3 during the decay upto 2020 mid-January and gradually increases to 1 as the source reaches hard state. Power density spectra generated in the 0.01−100 Hz range display no quasi-periodic oscillations, although band-limited noise is seen towards the end of 2020 January. During AstroSat observations, Γ lies in the range 2.3−2.6 and rms increases from 11 to 20 per cent, suggesting that the source was in an intermediate state till 2019 November 21. Spectral fitting with the relativistic disc model (kerrbb), in conjunction with the soft-hard transition luminosity, favour a black hole with mass $3\!-\!19\, \mathrm{ M}_{\odot }$ with retrograde spin at a distance &lt;15 kpc. Finally, we discuss the possible implications of our findings.
Shocks in the stacked Sunyaev–Zel’dovich profiles of clusters – I. Analysis with the Three Hundred simulations
Authors: Baxter Eric J , Adhikari Susmita , Vega-Ferrero Jesús , Cui Weiguang , Chang Chihway , Jain Bhuvnesh , Knebe Alexander 
Published: September 2021

ABSTRACT
Gas infalling into the gravitational potential wells of massive galaxy clusters is expected to experience one or more shocks on its journey to becoming part of the intracluster medium (ICM). These shocks are important for setting the thermodynamic properties of the ICM and can therefore impact cluster observables such as X-ray emission and the Sunyaev–Zel’dovich (SZ) effect. We investigate the possibility of detecting signals from cluster shocks in the averaged thermal SZ profiles of galaxy clusters. Using zoom-in hydrodynamic simulations of massive clusters from the Three Hundred Project, we show that if cluster SZ profiles are stacked as a function of R/R200m, shock-induced features appear in the averaged SZ profile. These features are not accounted for in standard fitting formulae for the SZ profiles of galaxy clusters. We show that the shock features should be detectable with samples of clusters from ongoing and future SZ surveys. We also demonstrate that the location of these features is correlated with the cluster accretion rate, as well as the location of the cluster splashback radius. Analyses of ongoing and future surveys, such as SPT-3g, AdvACT, Simons Observatory, and CMB-S4, which include gas shocks will gain a new handle on the properties and dynamics of the outskirts of massive haloes, both in gas and in mass.
An extreme case of galaxy and cluster co-evolution at z = 0.7
Authors: Ebeling H , Richard J , Smail I , Edge A C , Koekemoer A M , Zalesky L 
Published: September 2021

ABSTRACT
We report the discovery of eMACS J0252.4−2100 (eMACS J0252), a massive and highly evolved galaxy cluster at z = 0.703. Our analysis of Hubble Space Telescope imaging and VLT/MUSE and Keck/DEIMOS spectroscopy of the system finds a high-velocity dispersion of 1020$^{+180}_{-190}$ km s−1 and a high (if tentative) X-ray luminosity of (1.2 ± 0.4) × 1045 erg s−1 (0.1–2.4 keV). As extreme is the system’s brightest cluster galaxy, a giant cD galaxy that forms stars at a rate of between 85 and 300 M⊙ yr−1 and features an extended halo of diffuse [O ii] emission, as well as evidence of dust. Its most remarkable properties, however, are an exceptionally high ellipticity and a radially symmetric flow of gas in the surrounding intracluster medium, potential direct kinematic evidence of a cooling flow. A strong-lensing analysis, anchored by two multiple-image systems with spectroscopic redshifts, finds the best lens model to consist of a single cluster-scale halo with a total mass of (1.9 ± 0.1) × 1014 M⊙ within 250 kpc of the cluster core and, again, an extraordinarily high ellipticity of e = 0.8. Although further, in-depth studies across the electromagnetic spectrum (especially in the X-ray regime) are needed to conclusively determine the dynamical state of the system, the properties established so far suggest that eMACS J0252 must have already been highly evolved well before z ∼ 1, making it a prime target to constrain the physical mechanisms and history of the co-evolution or dark-matter haloes and baryons in the era of cluster formation.
NGC 5746: Formation history of a massive disc-dominated galaxy
Authors: Martig Marie , Pinna Francesca , Falcón-Barroso Jesús , Gadotti Dimitri A , Husemann Bernd , Minchev Ivan , Neumann Justus , Ruiz-Lara Tomás , van de Ven Glenn 
Published: September 2021

ABSTRACT
The existence of massive galaxies lacking a classical bulge has often been proposed as a challenge to ΛCDM. However, recent simulations propose that a fraction of massive disc galaxies might have had very quiescent merger histories, and also that mergers do not necessarily build classical bulges. We test these ideas with deep MUSE observations of NGC 5746, a massive (∼1011 M⊙) edge-on disc galaxy with no classical bulge. We analyse its stellar kinematics and stellar populations, and infer that a massive and extended disc formed very early: 80 per cent of the galaxy’s stellar mass formed more than 10 Gyr ago. Most of the thick disc and the bar formed during that early phase. The bar drove gas towards the centre and triggered the formation of the nuclear disc followed by the growth of a boxy/peanut-shaped bulge. Around ∼8 Gyr ago, a ∼1:10 merger happened, possibly on a low-inclination orbit. The satellite did not cause significant vertical heating, did not contribute to the growth of a classical bulge, and did not destroy the bar and the nuclear disc. It was however an important event for the galaxy: by depositing its stars throughout the whole galaxy it contributed ∼30 per cent of accreted stars to the thick disc. NGC 5746 thus did not completely escape mergers, but the only relatively recent significant merger did not damage the galaxy and did not create a classical bulge. Future observations will reveal if this is representative of the formation histories of massive disc galaxies.
On the road to per cent accuracy – V. The non-linear power spectrum beyond ΛCDM with massive neutrinos and baryonic feedback
Authors: Bose Benjamin , Wright Bill S , Cataneo Matteo , Pourtsidou Alkistis , Giocoli Carlo , Lombriser Lucas , McCarthy Ian G , Baldi Marco , Pfeifer Simon , Xia. Qianli 
Published: September 2021

ABSTRACT
In the context of forthcoming galaxy surveys, to ensure unbiased constraints on cosmology and gravity when using non-linear structure information, per cent-level accuracy is required when modelling the power spectrum. This calls for frameworks that can accurately capture the relevant physical effects, while allowing for deviations from Lambda cold dark matter (ΛCDM). Massive neutrino and baryonic physics are two of the most relevant such effects. We present an integration of the halo model reaction frameworks for massive neutrinos and beyond ΛCDM cosmologies. The integrated halo model reaction, combined with a pseudo-power spectrum modelled by HMCode2020 is then compared against N-body simulations that include both massive neutrinos and an f(R) modification to gravity. We find that the framework is 4 per cent accurate down to at least $k\approx 3 \, h\, {\rm Mpc}^{-1}$ for a modification to gravity of |fR0| ≤ 10−5 and for the total neutrino mass Mν ≡ ∑mν ≤ 0.15 eV. We also find that the framework is 4 per cent consistent with EuclidEmulator2 as well as the Bacco emulator for most of the considered νwCDM cosmologies down to at least $k \approx 3 \, h$ Mpc−1. Finally, we compare against hydrodynamical simulations employing HMCode2020’s baryonic feedback modelling on top of the halo model reaction. For νΛCDM cosmologies, we find 2 per cent accuracy for Mν ≤ 0.48 eV down to at least k ≈ 5h Mpc−1. Similar accuracy is found when comparing to νwCDM hydrodynamical simulations with Mν = 0.06 eV. This offers the first non-linear, theoretically general means of accurately including massive neutrinos for beyond-ΛCDM cosmologies, and further suggests that baryonic, massive neutrino, and dark energy physics can be reliably modelled independently.
Revealing the unusual structure of the KAT-7-discovered giant radio galaxy J0133−1302
Authors: Mhlahlo N , Jamrozy M 
Published: September 2021

ABSTRACT
We present a new study of the 1.7 Mpc KAT-7-discovered Giant Radio Galaxy, J0133−1302, which was carried out using GMRT data at 323 and 608 MHz. This source is located at RA 01h33m13s and Dec. −13○03′00″ and has a photometric redshift of ∼0.3. We discovered unusual morphological properties of the source which include lobes that are exceptionally asymmetric, where the upper lobe is much further from the core when compared to the lower lobe, and a complex structure of the upper lobe. The complex structure of the upper lobe hints at the presence of another source, in close proximity to the edge of the lobe, which resembles a bent-double, or distorted bent tail Radio Galaxy. Both the upper lobe and the lower lobe have a steep spectrum, and the synchrotron age of the lower lobe should be less than about 44 Myr. The core has an inverted spectrum, and our results suggest that the parent Galaxy in J0133−1302 is starting a new jet activity. Our spectral analysis indicates that this source could be a GigaHertz Peaked Spectrum radio Galaxy.
MLG: multilayer graph clustering for multi-condition scRNA-seq data
Authors: Lu Shan , Conn Daniel J , Chen Shuyang , Johnson Kirby D , Bresnick Emery H , Keleş Sündüz 
Published: September 2021

Abstract
Single-cell transcriptome sequencing (scRNA-seq) enabled investigations of cellular heterogeneity at exceedingly higher resolutions. Identification of novel cell types or transient developmental stages across multiple experimental conditions is one of its key applications. Linear and non-linear dimensionality reduction for data integration became a foundational tool in inference from scRNA-seq data. We present multilayer graph clustering (MLG) as an integrative approach for combining multiple dimensionality reduction of multi-condition scRNA-seq data. MLG generates a multilayer shared nearest neighbor cell graph with higher signal-to-noise ratio and outperforms current best practices in terms of clustering accuracy across large-scale benchmarking experiments. Application of MLG to a wide variety of datasets from multiple conditions highlights how MLG boosts signal-to-noise ratio for fine-grained sub-population identification. MLG is widely applicable to settings with single cell data integration via dimension reduction.
CLRM-09. INCORPORATING EXTERNAL CONTROL ARM IN MDNA55 RECURRENT GLIOBLASTOMA REGISTRATION TRIAL
Authors: Davi Ruthanna , Majumdar Antara , Bexon Martin , Butowski Nicholas , Chandhasin Chandtip , Coello Melissa , Das Sunit , Merchant Fahar , Merchant Nina , Reardon David , Roessner Martin , Sampson John 
Published: September 2021

Abstract

BACKGROUND
Drug development in recurrent glioblastoma multiforme (rGBM) is challenging. For randomized controlled trials (RCTs) short survival horizons and limited life-prolonging treatment options may delay accrual and introduce bias through differential dropout of control patients. Comparing results of a single-arm Phase 2b trial of intratumoral delivery of MDNA55 (an interleukin-4 receptor targeted fusion protein) to an external control arm, we sought early efficacy insights and consideration by the FDA of incorporating an ECA in a Phase 3 registrational trial.

METHODS
Using propensity score weighting, we compared rGBM patients from the Phase 2b trial (NCT02858895) (2017-2019) to patients from rGBM registries who had received standard of care therapies (2011-2019) and met eligibility requirements. Propensity scores were estimated using a logistic regression model with 11 covariates. We compared the propensity score weighted groups according to demographic and disease attributes before and after weighting and compared overall survival between the two groups.

RESULTS
Through propensity score weighting, 43 (98%, 43/44) MDNA55 patients and 40.80 weighted ECA patients (from 62 unweighted registry patients) were identified for comparison. MDNA55 and ECA patients were balanced on all baseline characteristics (i.e., standardized mean difference ≤ 0.15). Compared to ECA patients, MDNA55 patients had a 37% lower hazard of death (hazard ratio 0.63, 95% confidence interval: 0.39,1.02).

CONCLUSION
In advance of a Phase 3 trial, comparison of Phase 2b trial results to an ECA suggests that MDNA55 may be efficacious in rGBM. In view of the known challenges associated with drug development for rGBM, these results provided a proof-of-concept for the design of a novel hybrid Phase 3 trial. This planned Phase 3 trial incorporates propensity score weighting to create a composite hybrid randomized and external control arm, an approach preferred by the FDA over full replacement of a randomized control with an external control.
CLRM-10. THE INTER-RELATIONSHIP BETWEEN MULTI-MODAL LONGITUDINAL BIOMARKERS OF NEURAL DAMAGE, INFLAMMATION, AND COGNITION AFTER CAR T CELLULAR THERAPY: A SINGLE-CENTER PROSPECTIVE OBSERVATIONAL TRIAL (NCT04614987)
Authors: Butt Omar , Zhou Alice , Lee Ken , Wu Gregory , Song Sheng-Kwei , Campian Jian , DiPersio John , Ances Beau , Ghobadi Armin 
Published: September 2021

Abstract

BACKGROUND
Immune effector cell associated neurotoxicity syndrome (ICANS) remains a devastating, frequent complication of chimeric antigen receptor (CAR) T cell therapy for advanced-stage hematologic malignancies. Symptoms range from encephalopathy and headaches to aphasia, strokes, and diffuse cerebral edema. Persistent mild cognitive symptoms have also been reported. Unfortunately, the underlying pathophysiology driving ICANS is poorly understood. Current proposed models center on systemic inflammatory changes leading to endothelial dysfunction, blood-brain barrier (BBB) breakdown, and systemic cytokine and/or monocytes infiltration into the central nervous system (CNS). However, these models do not integrate predisposing risk factors for the development of ICANS. We previously demonstrated that pre-infusion plasma neurofilament light chain (NfL), a marker of neurodegeneration, may predict development of ICANS. Early elevations in NfL suggest development of ICANS is also related to pre-existing neuroaxonal injury. The longitudinal relationship between latent neuroaxonal injury, blood brain barrier (BBB) integrity, neuroinflammation, and cognition remains unknown.

METHODS
This prospective, observational trial examines the relationship between multi-modal (blood, cerebrospinal fluid (CSF), neuroimaging) biomarkers and cognition in a cohort of twenty patients undergoing standard-of-care CAR T cellular therapy. Biomarkers for neural injury include blood and CSF NfL and volumetric measures derived from structural magnetic resonance imaging (MRI). Biomarkers for neuroinflammation include blood and CSF glial fibrillary acidic protein (GFAP) and qualification of white matter hyper-intensity burden on MRI. BBB integrity will be quantified using the serum/CSF albumin ratio. Finally, neuropsychological performance testing will assay cognitive performance across multiple cortical domains including attention, memory, and executive function. Participants will undergo a baseline (pre-infusion) examination, followed by evaluation (blood draw, voluntary lumbar puncture, MRI scan, and cognitive testing) on post-infusion day 3 (D3), D30, D90, and D180. The primary outcome is percent change in a given biomarker level.

RESULTS/CONCLUSIONS
This ongoing trial has 2 of 20 planned participants enrolled.
CLRM-11. BENCH TO BEDSIDE NEURO-ONCOLOGY: ADVOCATING FOR A CLINICALLY RELEVANT STRATEGY AS UNDERSCORED BY THE PANDEMIC
Authors: Brown Timothy , Mansouri Alireza , Zammar Samer , Glantz Michael 
Published: September 2021

Abstract

INTRODUCTION
The basic science research endeavor has been abundantly and astonishingly successful in the last three decades in elucidating the mechanisms of neuro-oncologic disease and in suggesting therapeutic strategies. Clinical successes have lagged behind, and translation of promising laboratory findings into clinical practice is rare. We hypothesize that one important reason for this discordance is the use of different paradigms for designing laboratory and clinical trials, and that utilizing clinically relevant procedures could improve laboratory study impact.

METHODS
We identified all pre-clinical neuro-oncology therapeutic trials published in four high-impact journals between 11/2018 and 4/2019 and assigned a level of evidence (LOE) to each study using the American Academy of Neurology evidence classification system. We then identified all phase III trials of therapeutics for COVID and performed the same analysis on all preclinical studies preceding the trials.

RESULTS
Of the 26 neuro-oncology articles identified, 85% had a LOE of IV and 15% were class III. An analysis of successful human trials showed significantly more high quality laboratory studies supporting “successful” compared to “unsuccessful” trials (p=0.048). This same pattern was identified in phase III trials of COVID. Twenty antiviral studies failed to meet the primary endpoint; all were preceded by class III or IV LOE preclinical studies. Eight evaluable phase three studies of COVID vaccines were identified, all of which met their primary endpoints. These were supported with a mix of Class I/II (n=4) and III/IV (n=4) preclinical studies. Higher LOE by AAN criteria is associated with successful COVID therapeutic trials (p=0.0034).

CONCLUSIONS
Despite rigorous, elegant, and enlightening laboratory experiments, successful translation to human therapeutics remains rare. Envisioning basic science research through the lens of clinical therapeutics represents a challenging but surmountable paradigm shift that may reverse this pattern and create a more successful research enterprise in neuro-oncology and beyond.
NEIM-04. PROSPECTIVE STUDY OF SCREENING MRI OF THE BRAIN IN PATIENTS WITH METASTATIC OR INFLAMMATORY BREAST CANCER
Authors: Aizer Ayal , Catalano Paul , Chen Yu-Hui , Wickersham Lacey , Gavrilovic Alexandra , Lin Nancy 
Published: September 2021

Abstract

BACKGROUND
The management of brain metastases is often dictated by the size and number of lesions present, with more invasive/aggressive therapies such as resection and whole brain radiation utilized for more extensive intracranial disease. Consensus guidelines for patients with advanced lung cancer or melanoma recommend magnetic resonance imaging (MRI) of the brain to screen for brain metastases. Due to a lack of prospective studies demonstrating benefit, screening brain imaging is currently not recommended by consensus guidelines in breast cancer.

APPROACH
Eligible patients are those with breast cancer initiating first-fourth line chemotherapy for extracranial metastatic disease or unresectable local recurrence devoid of prior intracranial involvement. A study-specific MRI (3D T1 pre-contrast + 3D T1 post-contrast acquisition) was developed to limit scan time to approximately 10-12 minutes. Patients with HR+/HER2- and HER2+ positive disease are randomized to screening brain MRIs vs not (primary outcome: neurologic quality of life, target N=156) while all patients with triple negative breast cancer (TNBC) receive brain MRIs (primary outcome: rate of symptomatic brain metastases relative to historical controls, target N=33). Screened patients undergo one MRI at enrollment and, if negative, a second MRI at first systemic progression. In addition, an exploratory cohort of patients with inflammatory breast cancer (IBC) managed with curative intent is included, in which patients undergo brain MRIs at baseline and, if negative, every six months for two years (primary endpoint: cumulative incidence of brain metastases, target N=25). In all cohorts, a multidisciplinary discussion is convened to determine optimal management in cases where brain metastases are identified.

STUDY PROGRESS
The study activated in 2019. As of 7/9/21, 28 patients have been enrolled. Enrollment has been more robust in single arm cohorts (TNBC: 13/33 enrolled; IBC 8/25 enrolled) than in the randomized subset (7/156 enrolled). Updated accrual will be presented at the meeting.
Media as a Source of Sexual Socialization for Emerging Adults
Authors: Aubrey Jennifer Stevens , Dajches Leah , Terán Larissa 
Published: September 2021

Abstract
This chapter examines the role of three medium types—television and films, music and music videos, and pornography—in the sexual socialization of emerging adults. For television/films and music/music videos, researchers have found that increased exposure to both is associated with more gendered sexual beliefs and more sexually permissive attitudes and expectations. There is also evidence that exposure to mainstream television and movies is related to a variety of sexual behaviors, including age at sexual debut, sexual experience, and risky sexual behaviors. The literatures on music/music videos and pornography share a common interest in sexism, reporting that both types of media exposure are related to sexist beliefs and lax perceptions of sexual aggression. Pornography consumption is also correlated with more negative body image and higher relational dissatisfaction, which have consequences for the quality of emerging adults’ sexual experiences.
Parenting Post-9/11
Authors: Vermeulen Karla 
Published: September 2021

Abstract
The “Parenting Post-9/11” chapter examines the environment that Generation Disaster’s caregivers created within the family microsystem throughout their childhood and adolescence, as parents are generally the most important developmental influence during those formative years. It then considers how this cohort’s parents were impacted by 9/11 and all of the subsequent societal changes, as well as their fears about children’s safety amid the rise in school shootings, and it demonstrates how children’s responses to stressful and traumatic events are closely correlated with their caregivers’ reactions. The chapter considers whether accusations of “helicopter parenting” by these caregivers are valid, and it examines the impact of smartphones and other technologies on the first group of parents and children that had to incorporate these tools into their family dynamics.
Lockdown Drills in Kindergarten
Authors: Vermeulen Karla 
Published: September 2021

Abstract
This chapter, “Lockdown Drills in Kindergarten,” examines the primary childhood experience that sets Generation Disaster apart from previous cohorts: their early awareness of the threat of school shootings and other types of mass gun violence. It explores the impact of participating in school lockdown drills throughout primary and secondary school and how these security activities can increase distress and anxiety for some children. It describes how extremely rare school-based rampage attacks are relative to much more common forms of gun violence that receive less media attention. The chapter also discusses the role of social media in mass shootings, including as a motivator for copycat attacks and a source of vicarious trauma through exposing viewers to unfiltered images of violence.