bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive palaeomagnetic study of San Borja and Jaraguay monogenetic volcanic fields, Baja California (28–30°N): considerations on latitudinal corrections
Authors: Mahgoub A N , García-Amador B I , Alva-Valdivia L M 
Published: February 2021

SUMMARY
We report 24 palaeomagnetic directions and 10 high-quality Thellier-derived palaeointensity (PI) values, obtained from 27 sites located in Baja California Peninsula, northwestern Mexico. Sampling was done in four rock units (magnesian andesites, calc-alkaline lavas, ignimbrites, adakites) belonging to San Borja and Jaraguay monogenetic volcanic fields. These units have erupted between ∼15 and 2.6 Ma (previous K-Ar and 40Ar/39Ar data); hence results are presented in two consecutive periods: middle-late Miocene and Pliocene. The identified main magnetic minerals in the sampled sites are titanomagnetite, magnetite and minor hematite, of variable grain size, present as intergrowths or surrounding grains, which reflect varying oxidation/reduction conditions during emplacement of high-temperature magmas. Based on previous geological and geophysical records, the kinematic evolution was carefully considered in the region, allowing for the independent restoration of the palaeoposition of each sampled site. Previous palaeodirections were also evaluated and corrected for tectonic motion in order to combine them with present data. Accordingly, a number of 15 and 36 directional data are used to calculate palaeopole position for Pliocene and middle-late Miocene periods, respectively, selected from a total of 74 data points. Pliocene (Plat = 87.8°, Plong = 147.5°, K = 41.06, A95 = 6.0°) and middle-late Miocene (Plat = 86.0°, Plong = 172.7°, K = 41.08, A95 = 3.8°) palaeopole positions, calculated after tectonic corrections, are not statistically different from expected North American reference pole. Tectonic correction for Middle-late Miocene virtual geomagnetic poles plays an important role in reducing the resultant tilting from 2.7° to –0.8°. PI mean were calculated for Pliocene and middle-late Miocene periods at 29.2 ± 9.1 and 23.2 ± 6.3 μT, respectively. Compiling global filtered PI data, together with our results, indicates that the strength of the geomagnetic field during middle-late Miocene was weak (virtual dipole moment = 5.0 ± 2.2 × 1022 Am2) compared to Pliocene (6.4 ± 2.8 × 1022 Am2), and also relative to the present-day value (7.6 × 1022 Am2). This indicates the global nature of the low dipole moment during the middle-late Miocene period. However, issues related to the spatio-temporal distribution of PI data still present an obstacle to validating these suggestions; therefore, more reliable data are still needed.
Effectiveness and Safety of Nonmedical Switch From Adalimumab Originator to SB5 Biosimilar in Patients With Inflammatory Bowel Diseases: Twelve-Month Follow-Up From the TABLET Registry
Authors: Tapete Gherardo , Bertani Lorenzo , Pieraccini Alberto , Lynch Erica Nicola , Giannotta Martina , Morganti Riccardo , Biviano Ivano , Naldini Sara , Mumolo Maria Gloria , De Nigris Francesca , Calella Francesca , Bagnoli Siro , Minciotti Moira , Maltinti Simona , Rentini Silvia , Ceccarelli Linda , Lionetti Paolo , Milla Monica , Costa Francesco 
Published: February 2021

Abstract

Background
Few data are currently available about SB5 in inflammatory bowel diseases (IBD). The aim of this study was to assess the effectiveness and safety of SB5 in a cohort of patients with IBD in stable remission switched from the adalimumab (ADA) originator and in a cohort of patients with IBD naïve to ADA.

Methods
We prospectively enrolled patients with IBD who started ADA treatment with SB5 (naïve cohort) and those who underwent a nonmedical switch from the ADA originator to SB5 (switching cohort). Clinical remission and safety were assessed at baseline and at 3, 6, and 12 months. In addition, in a small cohort of patients who were switched, we assessed the ADA serum trough levels and antidrug antibodies at baseline, 3, and 6 months.

Results
In the naïve cohort, the overall remission rate at 12 months was 60.42%, whereas in the switching cohort it was 89.02%. Fifty-three (36.3%) patients experienced an adverse event, and injection site pain was the most common; it was significantly more frequent in the switching cohort (P = 0.001). No differences were found in terms of ADA serum trough levels at baseline, 3, and 6 months after switching. No patient developed antidrug antibodies after the switch.

Conclusions
We found that SB5 seemed effective and safe in IBD, both in the naïve cohort and in the switching cohort. Further studies are needed to confirm these data in terms of mucosal healing.
Measuring patient voice matters: setting the scene for patient-reported indicators
Authors: de Bienassis Katherine , Kristensen Solvejg , Hewlett Emily , Roe David , Mainz Jan , Klazinga Niek 
Published: February 2021

Abstract

Background
Achieving people-centred health care systems requires new and innovative strategies to capture information about whether, and to what degree, health care is successful in improving health from the perspective of the patient. Patient-reported outcome measures (PROMs) and Patient-reported experience measures (PREMs) can bring some of these new insights, and are increasingly used in research, clinical care, and policymaking.

Methods
This paper reflects the ongoing discussions and findings of the OECD PaRIS Working Group on Patient-reported Indicators for Mental Health Care.

Results
The OECD has been measuring quality of care for mental health conditions over the last 14 years through the Health Care Quality and Outcomes (HCQO) program; nonetheless, information on how persons with mental health problems value the services they receive, and impact of the services, remains limited. As of 2018, a survey from the OECD showed that only five of the twelve countries surveyed (Australia, Israel, Netherlands, Sweden, United Kingdom) reported PROMs and PREMs collection on a regular basis in mental health settings. The paper details some of the challenges specific to the collection and use of PROMs and PREMs in mental health care, and examples from countries which have implemented comprehensive programmes to gather information about PROMs and PREMs for individuals receiving mental health services.

Conclusions
Given the health and economic impact of mental ill-health across all OECD countries, there is significant value to being able to assess the quality and outcomes of care in this area using internationally-comparable measures. Continued international harmonisation of PROMs and PREMs for mental health through international coordination is a key way to facilitate the sharing of national experiences, promote the use of PROMs and PREMs, and create meaningful indicators for national and international benchmarking.
Efficacy and safety of subsequent molecular targeted therapy after immuno-checkpoint therapy, retrospective study of Japanese patients with metastatic renal cell carcinoma (AFTER I-O study)
Authors: Tomita Yoshihiko , Kimura Go , Fukasawa Satoshi , Numakura Kazuyuki , Sugiyama Yutaka , Yamana Kazutoshi , Naito Sei , Kabu Koki , Tajima Yohei , Oya Mototsugu 
Published: February 2021

Abstract

Objectives
Guidelines for treatment of mRCC recommend nivolumab monotherapy (NIVO) for treated patients, and nivolumab plus ipilimumab combination therapy (NIVO+IPI) for untreated IMDC intermediate and poor-risk mRCC patients. Although molecular-targeted therapies (TTs) such as VEGFR-TKIs and mTORi are recommended as subsequent therapy after NIVO or NIVO+IPI, their efficacy and safety remain unclear.

Methods
Outcome of Japanese patients with mRCC who received TT after NIVO (CheckMate 025) or NIVO+IPI (CheckMate 214) were retrospectively analyzed. Primary endpoints were investigator-assessed ORR of the first TT after either NIVO or NIVO+IPI. Secondary endpoints included TFS, PFS, OS and safety of TTs.

Results
Twenty six patients in CheckMate 025 and 19 patients in CheckMate 214 from 20 centers in Japan were analyzed. As the first subsequent TT after NIVO or NIVO+IPI, axitinib was the most frequently treated regimen for both CheckMate 025 (54%) and CheckMate 214 (47%) patients. The ORRs of TT after NIVO and NIVO+IPI were 27 and 32% (all risks), and median PFSs were 8.9 and 16.3 months, respectively. During the treatment of first TT after either NIVO or NIVO+IPI, 98% of patients experienced treatment-related adverse events, including grade 3–4 events in 51% of patients, and no treatment-related deaths occurred.

Conclusions
TTs have favorable antitumor activity in patients with mRCC after ICI, possibly via changing the mechanism of action. Safety signals of TTs after ICI were similar to previous reports. These results indicate that sequential TTs after ICI may contribute for long survival benefit.
Transcriptome-wide analysis of epitranscriptome and translational efficiency associated with heterosis in maize
Authors: Luo Jin-Hong , Wang Min , Jia Gui-Fang , He Yan 
Published: February 2021

Abstract
Heterosis has been extensively utilized to increase productivity in crops, yet the underlying molecular mechanisms remain largely elusive. Here, we generated transcriptome-wide profiles of mRNA abundance, m6A methylation, and translational efficiency from the maize F1 hybrid B73×Mo17 and its two parental lines to ascertain the contribution of each regulatory layer to heterosis at the seedling stage. We documented that although the global abundance and distribution of m6A remained unchanged, a greater number of genes had gained an m6A modification in the hybrid. Superior variations were observed at the m6A modification and translational efficiency levels when compared with mRNA abundance between the hybrid and parents. In the hybrid, the vast majority of genes with m6A modification exhibited a non-additive expression pattern, the percentage of which was much higher than that at levels of mRNA abundance and translational efficiency. Non-additive genes involved in different biological processes were hierarchically coordinated by discrete combinations of three regulatory layers. These findings suggest that transcriptional and post-transcriptional regulation of gene expression make distinct contributions to heterosis in hybrid maize. Overall, this integrated multi-omics analysis provides a valuable portfolio for interpreting transcriptional and post-transcriptional regulation of gene expression in hybrid maize, and paves the way for exploring molecular mechanisms underlying hybrid vigor.
Are there radio-loud and radio-quiet gamma-ray bursts?
Authors: Osborne Joshua A , Bagheri Fatemeh , Shahmoradi Amir 
Published: February 2021

ABSTRACT
The potential existence of two separate classes of Long-duration Gamma-Ray Bursts (LGRBs) with and without radio afterglow emission, corresponding to radio-bright/loud and radio-dark/quiet populations, has been recently argued and favoured in the GRB literature. The radio-quiet LGRBs have been found to have, on average, lower total isotropic gamma-ray emissions (Eiso) and shorter intrinsic prompt gamma-ray durations (e.g. T90z). In addition, a redshift −T90z anticorrelation has been discovered among the radio-loud LGRBs, which is reportedly missing in the radio-quiet class. Here, we discuss the significance of the differences between the energetics and temporal properties of the two proposed classes of radio-loud and radio-quiet LGRBs. We show that much of the proposed evidence in support of the two distinct radio populations of LGRBs can be explained away in terms of selection effects and sample incompleteness. Our arguments are based on the recent discovery of the relatively strong, highly significant positive correlation between the total isotropic emission (Eiso) and the intrinsic prompt duration (T90z) that is present in both populations of short-hard and long-soft GRBs, predicted, quantified, and reported for the first time by Shahmoradi (2013a;2013b) and Shahmoradi & Nemiroff (2015).
A self-supervised, physics-aware, Bayesian neural network architecture for modelling galaxy emission-line kinematics
Authors: Dawson James M , Davis Timothy A , Gomez Edward L , Schock Justus 
Published: February 2021

ABSTRACT
In the upcoming decades, large facilities, such as the SKA, will provide resolved observations of the kinematics of millions of galaxies. In order to assist in the timely exploitation of these vast data sets, we explore the use of a self-supervised, physics-aware neural network capable of Bayesian kinematic modelling of galaxies. We demonstrate the network’s ability to model the kinematics of cold gas in galaxies with an emphasis on recovering physical parameters and accompanying modelling errors. The model is able to recover rotation curves, inclinations and disc scale lengths for both CO and H i data which match well with those found in the literature. The model is also able to provide modelling errors over learned parameters, thanks to the application of quasi-Bayesian Monte Carlo dropout. This work shows the promising use of machine learning, and in particular, self-supervised neural networks, in the context of kinematically modelling galaxies. This work represents the first steps in applying such models for kinematic fitting and we propose that variants of our model would seem especially suitable for enabling emission-line science from upcoming surveys with e.g. the SKA, allowing fast exploitation of these large data sets.
RNA thermoswitches modulateStaphylococcus aureusadaptation to ambient temperatures
Authors: Catalan-Moreno Arancha , Cela Marta , Menendez-Gil Pilar , Irurzun Naiara , Caballero Carlos J , Caldelari Isabelle , Toledo-Arana Alejandro 
Published: February 2021

AbstractThermoregulation of virulence genes in bacterial pathogens is essential for environment-to-host transition. However, the mechanisms governing cold adaptation when outside the host remain poorly understood. Here, we found that the production of cold shock proteins CspB and CspC from Staphylococcus aureus is controlled by two paralogous RNA thermoswitches. Through in silico prediction, enzymatic probing and site-directed mutagenesis, we demonstrated that cspB and cspC 5′UTRs adopt alternative RNA structures that shift from one another upon temperature shifts. The open (O) conformation that facilitates mRNA translation is favoured at ambient temperatures (22°C). Conversely, the alternative locked (L) conformation, where the ribosome binding site (RBS) is sequestered in a double-stranded RNA structure, is folded at host-related temperatures (37°C). These structural rearrangements depend on a long RNA hairpin found in the O conformation that sequesters the anti-RBS sequence. Notably, the remaining S. aureus CSP, CspA, may interact with a UUUGUUU motif located in the loop of this long hairpin and favour the folding of the L conformation. This folding represses CspB and CspC production at 37°C. Simultaneous deletion of the cspB/cspC genes or their RNA thermoswitches significantly decreases S. aureus growth rate at ambient temperatures, highlighting the importance of CspB/CspC thermoregulation when S. aureus transitions from the host to the environment.
E pluribus unum? Political fractionalization and deviations from the law of one price in the USA
Authors: Antonini Massimo , Fielding David , Pires Jacinta 
Published: February 2021

Abstract
The magnitude of deviations from the Law of One Price (LOP) across cities depends on a number of characteristics, including language differences, distance, and other correlates of trade costs. We show that in the USA, political differences between cities are an equally important determinant of LOP deviations. LOP deviations are smaller if the cities are both strongly Democrat or both strongly Republican. These effects are of a similar order of magnitude to those of distance, and suggest that political differences represent a substantial barrier to competition.
Combined Endoscopic Endonasal and Contralateral Transmaxillary Approach for Petrous Cholesteatoma: 2-Dimensional Operative Video
Authors: Wang Wei-Hsin , Lan Ming-Ying , Snyderman Carl H , Gardner Paul A 
Published: February 2021

Abstract
This 59-yr-old man presented with headache, dizziness, diplopia, and right-side hearing impairment for years. The objective degree of hearing impairment was not available. Magnetic resonance imaging (MRI) showed a right petrous apex lesion centered behind the right petrous internal carotid artery and extending lateral to the medial aspect of the right internal auditory canal. A combined endoscopic endonasal and left contralateral transmaxillary (CTM) approach was performed, and gross-total resection was achieved. Peeling the cyst wall from the dura resulted in minor weeping. It was covered with a left-sided, vascularized nasoseptal flap. His dizziness and diplopia improved immediately after the surgery. Histopathology revealed an epidermoid cyst. In this surgical video, we demonstrate the key steps of the CTM approach for access to the petrous apex posterior to the petrous internal carotid artery (ICA).
The patient gave informed consent for surgery and video recording.
The Narrative Enjoyment and Appreciation Rationale
Authors: Tamborini Ron , Grady Sara M. , Baldwin Joshua , McClaran Nikki , Lewis Robert 
Published: February 2021

Abstract
The narrative enjoyment and appreciation rationale (NEAR) builds on dual-process logic to distinguish these two forms of audience response to media entertainment shaped by either an intuitive or deliberative processing system. Three message features are critical in determining how these systems govern response: (1) the absence or presence of intuition conflict in the narrative, (2) the extent to which different intuitions are made salient (i.e., emphasized in the plot), and (3) the satisfaction/thwarting of those salient intuitions, where satisfaction refers to reward for acts that conform to intuitions, and thwarting refers to the inverse of this. When all salient intuitive needs are satisfied by entertainment experience, positive affect produced by intuitive processes is labeled enjoyment. By comparison, when the entertainment experience satisfies the most salient intuitive needs, but not all salient intuitive needs, positive affect produced by deliberative processing is labeled appreciation.
Musical Congruity in Advertising
Authors: Oakes Steve , Abolhasani Morteza 
Published: February 2021

Abstract
This chapter provides a review of the empirical literature on music in advertising and uses the overarching concept of musical congruity (or musical fit) to identify underlying patterns and enable more meaningful analysis of frequently disparate studies. Established and emerging research themes in music and advertising are examined in depth. Although the chapter focuses mainly on the findings of quantitative studies, it concludes with a section examining the more recent phenomenon of netnographic research into music in advertising. Ways in which netnography builds upon ethnography for the digital age are examined. The chapter concludes with a discussion of future research themes in music and advertising.
EIN3-Mediated Ethylene Signaling Attenuates Auxin Response during Hypocotyl Thermomorphogenesis
Authors: Kim Jae Young , Park Young-Joon , Lee June-Hee , Kim Zee Hwan , Park Chung-Mo 
Published: February 2021

Abstract
The gaseous phytohormone ethylene plays vital roles in diverse developmental and environmental adaptation processes, such as fruit ripening, seedling establishment, mechanical stress tolerance and submergence escape. It is also known that in the light, ethylene promotes hypocotyl growth by stimulating the expression of PHYTOCHROME INTERACTING FACTOR3 (PIF3) transcription factor, which triggers microtubule reorganization during hypocotyl cell elongation. In particular, ethylene has been implicated in plant responses to warm temperatures in recent years. However, it is currently unclear how ethylene signals are functionally associated with hypocotyl thermomorphogenesis at the molecular level. Here, we show that ETHYLENE-INSENSITIVE3 (EIN3)-mediated ethylene signals attenuate hypocotyl thermomorphogenesis by suppressing auxin response. At warm temperatures, when the activity of the PIF4 thermomorphogenesis promoter is prominently high, the ethylene-activated EIN3 transcription factor directly induces the transcription of ARABIDOPSIS PP2C CLADE D7 (APD7) gene encoding a protein phosphatase that inactivates the plasma membrane (PM) H+-ATPase proton pumps. In conjunction with the promotive role of the PM H+-ATPases in hypocotyl cell elongation, our observations strongly support that the EIN3-directed induction of APD7 gene is linked with the suppression of auxin-induced cell expansion, leading to the reduction in thermomorphogenic hypocotyl growth. Our data demonstrate that APD7 acts as a molecular hub that integrates ethylene and auxin signals into hypocotyl thermomorphogenesis. We propose that the ethylene–auxin signaling crosstalks via the EIN3-APD7 module facilitate the fine-tuning of hypocotyl thermomorphogenesis under natural environments, which often fluctuate in a complex manner.
Epidemiology of Early and Late Onset Neonatal Sepsis in Very Low Birthweight Infants
Authors: Köstlin-Gille Natascha , Härtel Christoph , Haug Clara , Göpel Wolfgang , Zemlin Michael , Müller Andreas , Poets Christian F. , Herting Egbert , Gille Christian 
Published: February 2021

Background:
Sepsis is a major cause of death in neonates. Knowledge about epidemiology, risk factors, causative pathogens and outcome of neonatal sepsis is important to improve neonatal care. For Germany, only few data on neonatal sepsis in very low birth weight (VLBW) infants exist.

Methods:
Data from 14,926 preterm infants with birth weight <1500 g and gestational age between 22 0/7 weeks and 31 6/7 collected between January 2009 and December 2017 were analyzed for frequency of early-onset sepsis (EOS) and late-onset sepsis (LOS) and for causative pathogens. Risk factors for the development of EOS and LOS and outcomes after EOS and LOS were analyzed by multivariate logistic regression models.

Results:
EOS occurred in 1.1% of infants and LOS in 11.9%. Escherichia coli was the most common pathogen in EOS, coagulase-negative staphylococci in LOS. Multidrug-resistant organisms were detected in 8.4% of EOS and 3.9% of LOS cases. Risk factors for EOS were lower gestational age, intra-amniotic infection and spontaneous delivery. Risk factors for LOS were lower gestational age, small for gestational age, central lines, endotracheal ventilation and history of EOS. Both EOS and LOS were independently associated with adverse neonatal outcome.

Conclusions:
These data from a large German neonatal cohort confirm neonatal sepsis as the most common cause of morbidity and mortality in VLBW infants, as well as E. coli and coagulase-negative staphylococci as the most prevalent pathogens. Multidisciplinary approaches such as antibiotic stewardship, hygiene and feeding strategies are necessary to further reduce the burden of sepsis in VLBW infants.