bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemotherapy and the Risk of Alzheimer's Disease in Colorectal Cancer Survivors: Evidence From the Medicare System
Authors: Akushevich Igor , Yashkin Arseniy P. , Kravchenko Julia , Kertai Miklos D. 
Published: February 2021

PURPOSE: Evidence on the nature of the relationship between patients receiving chemotherapy as an essential part of guideline-concordant cancer care and the onset of Alzheimer's Disease (AD) and other adverse cognitive outcomes has been mixed. Biological mechanisms were proposed to support both a potentially beneficial and an adverse role. To explore the relationship between chemotherapy and onset of AD and other neurocognitive disorders (ND) in colorectal cancer survivors. METHODS: We conducted a retrospective cohort study of 135,834 individuals older than 65 years diagnosed with colorectal cancer between 1998 and 2007, using SEER-Medicare data. A proportional hazards model was used before and after the use of inverse probability weighting to account for populational differences between the chemotherapy and nonchemotherapy groups. Weights were normalized to the total sample size. RESULTS: After inverse probability weighting, chemotherapy was associated with decreased AD risk (hazard ratio [HR]: 0.791; 95% CI: 0.758 to 0.824) and lower risk for the majority of other ND including AD-related diseases (HR: 0.823; CI: 0.802 to 0.844), dementia (permanent mental disorder) (HR: 0.807; CI: 0.782 to 0.832), and dementia (senile) (HR: 0.772; CI: 0.745 to 0.801). The only adverse effect to remain significant was cerebral degeneration (excluding AD) (HR: 1.067; CI: 1.033 to 1.102). The effects for AD remained after treatment was stratified by chemotherapy agent type and remained significant for up to 6 years past diagnosis. CONCLUSION: Chemotherapy use in colorectal cancer survivors demonstrated an association with reduced risk for AD and other ND.
Hawking temperature of black holes using the EUP and EGUP formalisms based on the Einstein-Bohr's photon box
Authors: Farahani N. , Hassanabadi H. , Chung W. S. , Lütfüoğlu B. C. , Zarrinkamar S. 
Published: February 2021

Abstract
In this paper, by studying the Einstein-Bohr's photon box for weighting a photon, we find that the effective Newton constant can be proposed by the extended uncertainty principle and extended generalized uncertainty principle. We obtain the modified Hawking temperature, mass, specific heat, and entropy by using the modified Schwarzschild metric.
Investigating the Relationship Between IGF-I, IGF-II, and IGFBP-3 Concentrations and Later-Life Cognition and Brain Volume
Authors: Salzmann Antoine , James Sarah-Naomi , Williams Dylan M , Richards Marcus , Cadar Dorina , Schott Jonathan M , Coath William , Sudre Carole H , Chaturvedi Nishi , Garfield Victoria 
Published: February 2021

Abstract

Background
The insulin/insulin-like signaling (IIS) pathways, including insulin-like growth factors (IGFs), vary with age. However, their association with late-life cognition and neuroimaging parameters is not well characterized.

Methods
Using data from the British 1946 birth cohort, we investigated associations of IGF-I, IGF-II and IGF binding protein 3 (IGFBP-3; measured at 53 and 60-64 years of age) with cognitive performance [word-learning test (WLT) and visual letter search (VLS) at 60-64 years and 69 years of age] and cognitive state [Addenbrooke’s Cognitive Exam III (ACE-III) at 69-71 years of age], and in a proportion, quantified neuroimaging measures [whole brain volume (WBV), white matter hyperintensity volume (WMHV), hippocampal volume (HV)]. Regression models included adjustments for demographic, lifestyle, and health factors.

Results
Higher IGF-I and IGF-II at 53 years of age was associated with higher ACE-III scores [ß 0.07 95% confidence interval (CI) (0.02, 0.12); scoreACE-III 89.48 (88.86, 90.1), respectively). IGF-II at 53 years of age was additionally associated with higher WLT scores [scoreWLT 20 (19.35, 20.65)]. IGFBP-3 at 60 to 64 years of age was associated with favorable VLS score at 60 to 64 and 69 years of age [ß 0.07 (0.01, 0.12); ß 0.07 (0.02, 0.12), respectively], higher memory and cognitive state at 69 years of age [ß 0.07 (0.01, 0.12); ß 0.07 (0.01, 0.13), respectively], and reduced WMHV [ß −0.1 (−0.21, −0.00)]. IGF-I/IGFBP-3 at 60 to 64 years of was associated with lower VLS scores at 69 years of age [ß −0.08 (−0.15, −0.02)].

Conclusions
Increased measure in IIS parameters (IGF-I, IGF-II, and IGFBP-3) relate to better cognitive state in later life. There were apparent associations with specific cognitive domains (IGF-II relating to memory; IGFBP-3 relating to memory, processing speed, and WMHV; and IGF-I/IGFBP-3 molar ratio related to slower processing speed). IGFs and IGFBP-3 are associated with favorable cognitive function outcomes.
Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells
Authors: Palacios Victor , Kimble Garrett C. , Tootle Tina L. , Buszczak Michael 
Published: February 2021

ABSTRACT
Germ cells undergo distinct nuclear processes as they differentiate into gametes. Although these events must be coordinated to ensure proper maturation, the stage-specific transport of proteins in and out of germ cell nuclei remains incompletely understood. Our efforts to genetically characterize Drosophila genes that exhibit enriched expression in germ cells led to the finding that loss of the highly conserved Importin β/karyopherin family member Importin-9 (Ipo9, herein referring to Ranbp9) results in female and male sterility. Immunofluorescence and fluorescent in situ hybridization revealed that Ipo9KO mutants display chromosome condensation and segregation defects during meiosis. In addition, Ipo9KO mutant males form abnormally structured sperm and fail to properly exchange histones for protamines. Ipo9 physically interacts with proteasome proteins, and Ipo9 mutant males exhibit disruption of the nuclear localization of several proteasome components. Thus, Ipo9 coordinates the nuclear import of functionally related factors necessary for the completion of gametogenesis.
This article has an associated First Person interview with the first author of the paper.
Nonplacebo Controls to Determine the Magnitude of Ergogenic Interventions: A Systematic Review and Meta-analysis
Authors: MARTICORENA FELIPE MIGUEL , CARVALHO ARTHUR , OLIVEIRA LUANA FARIAS DE , DOLAN EIMEAR , GUALANO BRUNO , SWINTON PAUL , SAUNDERS BRYAN 
Published: February 2021

ABSTRACT

Introduction
Placebos are used as a control treatment that is meant to be indistinguishable from the active intervention. However, where substantive placebo effects may occur, studies that do not include a nonplacebo control arm may underestimate the overall effect of the intervention (active plus placebo components). This study aimed to determine the relative magnitude of the placebo effect associated with nutritional supplements (caffeine and extracellular buffers) by meta-analyzing data from studies containing both placebo and nonplacebo control sessions.

Methods
Bayesian multilevel meta-analysis models were used to estimate pooled effects and express the placebo effect as a percentage of the overall intervention effect.

Results
Thirty-four studies were included, with the median pooled effect size (ES0.5) indicating a very small (ES0.5 = 0.09 (95% credible interval (CrI), 0.01–0.17)) improvement in the performance of placebo compared with control. There was no moderating effect of exercise type (capacity or performance), exercise duration, or training status. The comparison between active intervention and control indicated a small to medium effect (ES0.5 = 0.37 (95% CrI, 0.20–0.56)). Expressed in relative terms, the placebo effect was equivalent to 25% (75% CrI, 16%–35%) and 59% (75% CrI, 34%–94%) of the total intervention effect for buffers and caffeine.

Conclusions
These results demonstrate a very small but potentially important placebo effect with nutritional supplementation studies. A substantive proportion of supplement effects may be due to placebo effects, with the relative proportion influenced by the magnitude of the overall ergogenic effect. Where feasible, intervention studies should use nonplacebo control-arm comparators to identify the proportion of the effect estimated to come from placebo effects and avoid underestimating the overall benefits that the physiological plus psychobiological aspects associated with an intervention provide in the real world.
Kuidas pääseda löögile rahvusvahelistes ajakirjades?
Authors: Lust Kersti 
Published: February 2021

The number of Estonian historians who publish regularly in international journals is fairly small. The aim of this article is to encourage historians to take this step and to give tips on how to succeed in the increasingly competitive world of international publishing. The tips are based on the lectures presented at the summer school “How to get published?” (organised by Tallinn University in 2019) alongside the author’s experiences and conversations with other colleagues. The topics considered include how to select a journal, compose an article and its key parts, impress editors and please peer-reviewers. Special attention is paid to the importance of language and style. Having a native speaker read the draft is essential.
The article provides both general guidelines as well as specific suggestions for how to publish on Estonian history. The paper describes the main characteristics of what has been called the “Anglo-American model of academic writing”. The colleagues interviewed for the article agreed that, in principle, it would be possible to publish on most topics of Estonian history and there is no need to pick a globally attractive and currently trending topic. For that, the research question has to be linked to global or European developments, events or phenomena and to discussions in the respective field of research. The colleagues, however, disagreed on the issue of whether it is more important to follow the conventional style and format of the journal or to present novel ideas. There was a consensus that surprising source material, intriguing results, and high-quality English certainly increase the article’s chances of getting published.
Finance and Firm Volatility: Evidence from Small Business Lending in China
Authors: Chen Tao , Huang Yi , Lin Chen , Sheng Zixia 
Published: February 2021

The online trading platform Alibaba provides financial technology (FinTech) credit for millions of micro, small, and medium-sized enterprises (MSMEs). Using a novel data set of daily sales and an internal credit score threshold that governs the allocation of credit, we apply a fuzzy regression discontinuity design (RDD) to explore the causal effect of credit access on firm volatility. We find that credit access significantly reduces firm sales volatility and that the effect is stronger for firms with fewer alternative sources of financing. We further look at firm exit probability and find that firms with access to FinTech credit are less likely to go bankrupt or exit the business in the future. Additional channel tests reveal that firms with FinTech credit invest more in advertising and product/sector diversification, particularly during business downturns, which serves as effective mechanisms through which credit access reduces firm volatility. Overall, our findings contribute to a better understanding of the role of FinTech credit in MSMEs. This paper was accepted by Haoxiang Zhu, finance.
Kinesio taping techniques for ankle stabilisation in patients with stroke: a single-blinded randomised controlled study
Authors: Kurul Ramazan , Cankaya Tamer , Yildirim Necmiye Un 
Published: February 2021

Background/AimsAnkle proprioception and neuromuscular feedback from this region provides the sensory input needed for balance. The aim of this study was to investigate the effects of repeated correction taping applied on the ankle and peroneus longus and peroneus brevis muscles on balance and gait in patients with stroke.MethodsA total of 61 patients with stroke with a mean age of 62.25 ± 7.04 years were included in this study. The patients were randomly divided into two groups. The control group (n=30) received 1 hour of rehabilitation, which took place during weekdays over the course of 2 weeks. The intervention group (n=31) received 1 hour of daily rehabilitation as well as having kinesio tape applied to their ankle. Both groups were assessed with the Balance Evaluating Systems Test, Timed Up and Go Test, Functional Reach Test, Tetrax Balance System and Barthel Index. Clinical assessments were performed at baseline, immediately after the first application, 1 week and 2 weeks later, following the first taping.ResultsThere was a significant improvement in the Balance Evaluating Systems and Functional Reach Tests scores between the first and last measurements in favour of the intervention group (P<0.05). There were no significant changes between baseline and immediately after assessment for all measurements (P>0.05). There was no significant difference in Tetrax scores, Timed Up and Go Test and Barthel Index scores (P>0.05).ConclusionsIn this study, it was found that dynamic balance was improved by taping the peroneus longus and peroneus brevis muscles, but the static balance did not change. One week of kinesio taping would be beneficial; however, prolonged use would not provide further improvement.
Creating an action plan to advance knowledge translation in a domestic violence research network: a deliberative dialogue
Authors: Cameron Jacqui , Humphreys Cathy , Kothari Anita , Hegarty Kelsey 
Published: February 2021

Background: There is limited research on how knowledge translation of a domestic violence (DV) research network is shared. This lack of research is problematic because of the complexity of establishing a research network, encompassing diverse disciplines, methods, and focus of study potentially impacting how knowledge translation functions.
Aims and objectives: To address the limited research, we completed a deliberative dialogue with the following questions: Is there a consensus regarding a coherent knowledge translation framework for a domestic violence research network? What are the key actions that a domestic violence research network could take to enhance knowledge translation?
Methods: Deliberative dialogue is a group process that blends research and practice to identify potential actions. In total, 16 participants attended three deliberative dialogue meetings. We applied a qualitative analysis to the data to identify the key actions.
Findings: The deliberative dialogue facilitated mutual agreement regarding four key actions: (1) agreement on a knowledge translation approach; (2) active promotion of dedicated leadership within an authorising environment; (3) development of sustainable partnerships through capacity building and collaboration, particularly with DV survivors; and (4) employment of multiple strategies applying different kinds of evidence for diverse purposes and emerging populations.
Discussion and conclusions: The use of the deliberative dialogue has uncovered specific factors required for the successful knowledge translation of domestic violence research. These factors have been added to the Integrated Knowledge Translation (IKT) capacity framework to enhance its application for domestic violence research. Future research could explore these organisational, professional and individual factors further by evaluating them in practice.
Using prototyping to choose a bioinformatics workflow management system
Authors: Jackson Michael , Kavoussanakis Kostas , Wallace Edward W. J. 
Published: February 2021

Workflow management systems represent, manage, and execute multistep computational analyses and offer many benefits to bioinformaticians. They provide a common language for describing analysis workflows, contributing to reproducibility and to building libraries of reusable components. They can support both incremental build and re-entrancy—the ability to selectively re-execute parts of a workflow in the presence of additional inputs or changes in configuration and to resume execution from where a workflow previously stopped. Many workflow management systems enhance portability by supporting the use of containers, high-performance computing (HPC) systems, and clouds. Most importantly, workflow management systems allow bioinformaticians to delegate how their workflows are run to the workflow management system and its developers. This frees the bioinformaticians to focus on what these workflows should do, on their data analyses, and on their science.
RiboViz is a package to extract biological insight from ribosome profiling data to help advance understanding of protein synthesis. At the heart of RiboViz is an analysis workflow, implemented in a Python script. To conform to best practices for scientific computing which recommend the use of build tools to automate workflows and to reuse code instead of rewriting it, the authors reimplemented this workflow within a workflow management system. To select a workflow management system, a rapid survey of available systems was undertaken, and candidates were shortlisted: Snakemake, cwltool, Toil, and Nextflow. Each candidate was evaluated by quickly prototyping a subset of the RiboViz workflow, and Nextflow was chosen. The selection process took 10 person-days, a small cost for the assurance that Nextflow satisfied the authors’ requirements. The use of prototyping can offer a low-cost way of making a more informed selection of software to use within projects, rather than relying solely upon reviews and recommendations by others.
Reduction in live births in Japan nine months after the Fukushima nuclear accident: An observational study
Authors: Körblein Alfred 
Published: February 2021

Background
After the Chernobyl accident on 26 April 1986, a drop in birth-rate was found in several European countries in the first quarter of 1987. The objective of the present study was to investigate whether a similar drop in live births occurred in Japan after the Fukushima nuclear accident.

Data and methods
A study region was defined consisting of Fukushima prefecture plus 10 nearby prefectures. The observed monthly numbers of live births (LB) in October 2011 through December 2012 were compared with the predicted numbers determined from the trend of live births in the remaining months from January 2006 through December 2018. The study region was divided into Fukushima plus three adjacent prefectures (Area A, assumed effective mean dose in the first year 1 mSv) and seven surrounding prefectures (Area B, 0.5 mSv). The rest of Japan (Area C) served as the comparison (control) region (0.1 mSv). A combined regression of live births (LB) in areas A, B, C was conducted with individual trend parameters but common parameters for monthly variations.

Results
In the study region as a whole (areas A and B combined) a highly significant 9.1% (95% CI: -12.2%, -6.0%) drop in LB was found in December 2011. Reduced numbers of live births were also observed in October-November 2011 (-3.3%, p = 0.006), i.e. in births exposed early in pregnancy. In the second quarter of 2012, i.e. in live births conceived more than 3 months after the Fukushima accident, the decrease was greater (-4.3%, p < 0.001) than in the first quarter (-1.6%, p = 0.11). i.e. in those conceived within the first three months after the accident while no significant decrease was detected in the third (-0.7%, p = 0.44) and fourth (-0.5%, p = 0.62) quarters. The effect in Dec 2011 was greater in Area A with -14.0 (-17.6, -10.3) % than in Area B with -7.8 (-11.1, -4.5) % and non-significant in Area C with -1.3 (-4.2, +1.6) %, p = 0.38. The combined regression of the data in areas A, B, and C found a highly significant association of the effect in December 2011 with radiation dose. Conclusion: It is suggested that the observed drop in LB in December 2011 may reflect early deaths of the conceptus from high radiation exposure following the triple meltdown at the Fukushima Daiichi nuclear power plant on March 12–15, 2011.
Systematic review of Integrated Disease Surveillance and Response (IDSR) implementation in the African region
Authors: Wolfe Caitlin M. , Hamblion Esther L. , Dzotsi Emmanuel K. , Mboussou Franck , Eckerle Isabelle , Flahault Antoine , Codeço Claudia T. , Corvin Jaime , Zgibor Janice C. , Keiser Olivia , Impouma Benido 
Published: February 2021

Background
The WHO African region frequently experiences outbreaks and epidemics of infectious diseases often exacerbated by weak health systems and infrastructure, late detection, and ineffective outbreak response. To address this, the WHO Regional Office for Africa developed and began implementing the Integrated Disease Surveillance and Response strategy in 1998.

Objectives
This systematic review aims to document the identified successes and challenges surrounding the implementation of IDSR in the region available in published literature to highlight areas for prioritization, further research, and to inform further strengthening of IDSR implementation.

Methods
A systematic review of peer-reviewed literature published in English and French from 1 July 2012 to 13 November 2019 was conducted using PubMed and Web of Science. Included articles focused on the WHO African region and discussed the use of IDSR strategies and implementation, assessment of IDSR strategies, or surveillance of diseases covered in the IDSR framework. Data were analyzed descriptively using Microsoft Excel and Tableau Desktop 2019.

Results
The number of peer-reviewed articles discussing IDSR remained low, with 47 included articles focused on 17 countries and regional level systems. Most commonly discussed topics were data reporting (n = 39) and challenges with IDSR implementation (n = 38). Barriers to effective implementation were identified across all IDSR core and support functions assessed in this review: priority disease detection; data reporting, management, and analysis; information dissemination; laboratory functionality; and staff training. Successful implementation was noted where existing surveillance systems and infrastructure were utilized and streamlined with efforts to increase access to healthcare.

Conclusions and implications of findings
These findings highlighted areas where IDSR is performing well and where implementation remains weak. While challenges related to IDSR implementation since the first edition of the technical guidelines were released are not novel, adequately addressing them requires sustained investments in stronger national public health capabilities, infrastructure, and surveillance processes.