bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of urine steroid profiles by gas chromatography-mass spectrometry in patients with adrenocortical cancer in the course of treatment
Authors: Velikanova L. I. , Vorokhobina N. V. , Shafigullina Z. R. , Bokhian V. Yu. , Stilidi I. S. , Kalugina V. V. , Malevanaya E. V. , Strelnikova E. G. , Kushlinskii N. E. 
Published: October 2021

Background: Adrenocortical carcinoma (ACC) is a rare and aggressive disease. There are only few studies evaluating the diagnostic value of gas chromatography-mass spectrometry (GC-MS) for detection of ACC recurrence after surgery. It is necessary to conduct an in-depth study to search for the most informative markers of the disease relapse.Aim: To study urine steroid metabolism by GC-MS during treatment to identify early signs of metastatic disease and relapse.Materials and methods: Thirty nine (39) ACC patients were examined before and after surgery, in the early postoperative period (< 1 year) and late postoperative period (at 2 to 5 years). Ten (10) patients were disease-free at less than 1 year after surgery. Twenty nine (29) patients had metastases in lungs and other organs: 14, within 1 year after surgery, and 15, at 2 to 5 years. The control group included 25 patients with nonfunctioning adrenocortical adenomas (NAA) without malignant characteristics at histological examination. Urine steroid profiles were assessed with a gas chromatograph-mass spectrometer Shimadzu GCMS-QP2020.Results: As assessed by GC-MS, 16 major ACC biomarkers were found before surgery, including etiocholanolone, dehydroepiandrosterone (DHEA) and its metabolites, pregnanediol, pregnanetriol, 5-ene-pregnenes, and tetrahydro-11-deoxycortisol (THS). Their urine excretion was increased compared to that in the patients with NAA (р < 0.002). A non-classic 5-ene-pregnene, 3β,16,20-pregnenetriol (3β,16,20-dP3), was identified, with its urine excretion of > 500 mcg/day that was typical for ACC patients. After surgery, decreased urinary excretion of THS (р < 0.0001) and 3β,16,20-dP3 (р < 0.0001), increased 3α,16,20-dP3/3β,16,20-dP3 ratio (р = 0.003), compared to those before surgery, were indicative of the absence of any metastases. No difference of urine THS excretion and 3α,16,20-dP3/3e,16,20-dP3 ratio from the corresponding values before surgery (p > 0.05) is a sign of metastatic diseases in the ACC patients at less than 1 year after the surgery, of the disease relapse at 2 to 5 years, and of the disease relapse after chemotherapy. In addition, in the ACC patients with metastatic disease within 1 year after surgery, increased progestogen urine excretion was found. Urine excretion of DHEA and its metabolites in the patients with the disease relapse after chemotherapy was not different from those in the ACC patients before surgery (p > 0.05).Conclusion: Determination of urine excretion of THS, DHEA and its metabolites, etiocholanolone, 5-ene-pregnenes, 3β,16,20-dP3, and 3α,16,20-dP3/3β,16,20-dP3 ratio by GC-MS is of utmost importance in the monitoring of treatment for ACC and early diagnosis of the disease progression.
МИНЕРАЛОГИЯ БАРИТ-ПОЛИМЕТАЛЛИЧЕСКИХ МЕСТОРОЖДЕНИЙ ЗМЕИНОГОРСКОГО РУДНОГО РАЙОНА (РУДНЫЙ АЛТАЙ)
Authors: Бестемьянова Ксения Викторовна , Гринев Олег Михайлович 
Published: October 2021

Актуальность исследования обусловлена пониманием важности разработки современной генетической модели изучаемых месторождений, что в свою очередь ведет к разработке научно-обоснованных прогноза и оценки объектов и в итоге расширению минерально-сырьевой базы для воспроизводства запасов полиметаллических руд, прежде всего, меди свинца и цинка, с учетом продолжающихся поисково-разведочных работ на Рудном Алтае, в том числе на флангах и глубоких горизонтах уже известных месторождений. Цель: изучение минерального состава руд с использованием современных методов исследования вещества, выявление минералого-геохимических характеристик, а также ряда генетических аспектов образования барит-полиметаллических руд месторождений Змеиногорского рудного района. Методы. Проведено комплексное исследование барит-полиметаллических руд, включающее характеристику минерализации в поляризационном микроскопе, исследование руд и отдельных сульфидных минералов рентгеновским энерго-дисперсионным микроанализом, масс спектрометрическим с индуктивно связанной плазмой (ICP-MS), атомно-абсорбционным, а также масс-спектрометрическим изотопным анализом. Результаты. Изучена минералогия руд барит-полиметаллических месторождений Змеиногорского рудного района, насчитывающая порядка 30 минералов, среди которых, в порядке убывания, отмечены: сульфиды, сульфасоли, теллуриды, окислы, соли кислородных кислот, самородные элементы и интерметаллические соединения. Выделены основные минеральные парагенезисы, соответствующие последовательным стадиям минералообразования (рудной составляющей): пирит-сфалерит-халькопиритовая ассоциация, отвечающая первой стадии минералообразования; галенит-блекловорудная ассоциация (вторая стадия); борнит-халькозиновая ассоциация (третья стадия); барит-кальцит-гематитовая ассоциация (четвертая стадия). Изучен химический состав основных и примесных компонентов в сульфидах, выявлены ранее не диагностированные минералы. Установлена наиболее продуктивная на выделение самостоятельных минеральных фаз благородных металлов третья стадия (борнит-халькозиновый парагенезис). Источник вещества в процессе рудообразования имел гетерогенный характер, который обусловлен мантийными изотопными метками при начальных стадиях и сменой их на коровые, вариации изотопных характеристик (δ34S) сульфидов первой стадии –0,2…+1,2 ‰; сульфидов второй стадии –2,3…–3,7 ‰; сульфидов третьей стадии –8,9…–12,8 ‰.
IMPLEMENTASI GAME SEBAGAI MEDIA SOSIALISAI MITIGASI GUNNG MELETUS PADA SISWA SD KELAS 4 DENGAN MENGGUNAKAN METODE FINITE STATE MACHINE DAN FUZZY SUGENO
Authors: Muqorrobin Yastaqiim 
Published: October 2021

Indonesia merupakan negara yang rentan terhadap bencana. Salah satunya adalah gempa bumi dan gunung meletus. Edukasi tentang mitigasi bencana perlu dikenalkan sejak usia dini, tidak terkecuali untuk siswa sekolah dasar. Saat ini, media edukasi untuk menumbuhkan kemandirian dan keselamatan dalam keadaan darurat bagi siswa sekolah dasar masih sangat kurang. Kurangnya media edukasi untuk mengenali, mencegah, atau menyelamatkan diri dari situasi berbahaya, serta keterampilan berkomunikasi untuk melaporkan situasi apabila terjadi. Sehubungan dengan pesatnya perkembangan teknologi, game virtual telah menjadi salah satu teknologi yang populer di zaman ini. Oleh karena itu, perlu adanya game edukasi yang berisi mitgasi berupa simulasi dan pengetahuan mengenai mitigasi bencana. Game sebagai media pendekatan diharapkan masyarakat khususnya siswa SD Kelas 4 dapat mengenali dan mengatasi berbagai ancaman dan dampak dari bencana gunung meletus dan gempa. selain itu akan memudahkan pemerintah untuk mengatasi beberapa kendala dari sosialisasi mitigasi bencana yang dilakukan secara tradisional. Pada penelitian ini membahas tentang penerapan fuzzy Sugeno kedalam game sosilasisasi mitigasi dan memfokuskan bagaimana respon dari NPC kepada player dengan menggunakan kecerdasan buatan (Artificial Intelligence) sebagai jenis pemograman yang dapat melakukan tindakan serta berpikir secara rasional pada saat yang bersamaan maupun tidak. Hasil yang didapatkan bahwa metode fuzzy Sugeno dan finite state machine berhasil diterapkan pada perilaku NPC pada game dengan hasil persentase pada setiap varaibel memiliki nilai perbedaan yang tidak cukup jauh yang menunjukkan bahwa banyaknya nilai kemungkinan perilaku NPC yang akan muncul. Berdasarkan uji coba yang dilakukan pada siswa, diketahui bahwa persentase kriteria M memiliki nilai persentase yang paling besar sehingga game dapat dikatakan dalam kategori menyenangkan.
The Helen Keller Question Applied to Workplace Discrimination: Hearing Loss vs. Visual Loss
Authors: McMahon Brian T. , Leslie Mykal J. , Li Grace W. , Rumrill Phillip D. , Simpson Paige E. , Grover James M. 
Published: October 2021

BackgroundIn exploring the matter of sensory loss and job discrimination, the National EEOC ADA Research Project (NEARP) seeks to answer a singular question.ObjectiveHow do persons with hearing loss (HL) vs. visual loss (VL) experience the nature and scope of workplace discrimination differently, if at all?MethodsThe NEARP team uses an ex post facto, causal comparative quantitative design that includes descriptive and inferential, nonparametric statistics. Closed EEOC files involving ADA allegations of workplace discrimination filed by Americans with Hearing Loss (HL, N = 21,847) and Vision Loss (VL, N = 16,136) were compared in terms of demographics, issues, and investigatory outcomes.ResultsHL and VL groups show Demographic differences to one another and to population statistics of sensory impairment in the areas of Gender and Race/Ethnicity. Regarding Issues, HL and VL groups are different from one another with respect to several prevalent matters (i.e., Discharge, Reasonable Accommodation) and small-scale matters (i.e., Hiring and Terms/Conditions). With respect to the Merit of allegations following EEOC investigation, HL and VL are very similar.ConclusionWorkplace discrimination is experienced differently for Charging Parties who experience HL vs. VL. Moreover, important differences exist Charging Parties from both sensory impairments vs. those from a General Disability Population.
Examining the Relationships Between Social Determinants of Health and Health-Related Quality of Life Among Individuals Living With HIV
Authors: Chiu Yung-Chen Jen , Boomer KB , Conyers Liza , Wang Yili , Misrok Mark 
Published: October 2021

PurposeThe current study examined the relationships between health-related quality of life (HRQOL) and social determinants of health (SDH), which are the individual and structural factors that contribute to health outcomes.MethodA hierarchical general linear model was used to assess the sequential effect of the SDH on the scores of the Short Form-12 among people living with HIV.ResultsResults show that many psychosocial, medical, demographic, financial, and vocational factors are significant predictors of HRQOL.ConclusionsGaining a deeper understanding of the impact of SDH on HRQOL is critical for rehabilitation counselors to develop effective assessments and interventions.
A A incerteza na docência
Authors: Caroline Kloss  
Published: October 2021

Este estudo teve como objetivo investigar a presença da incerteza na docência, a partir de um diálogo teórico-prático. A parte teórica foi constituída a partir dos autores Boaventura Sousa Santos (2006), Maria Isabel da Cunha (2002), Paulo Freire (1996; 1987) e Edgar Morin (2001; 2005). E a parte prática foi constituída por relatos reflexivos acerca de um estágio no ensino superior. Os procedimentos metodológicos basearam-se no pensamento complexo (MORIN; CIURANA; MOTTA, 2003) que presume a subdivisão do método em programa e estratégia, tomando como guia o objetivo geral e deixando que as problematizações surgissem no decorrer do diálogo (teórico-prático). A reflexão partiu de três frentes diferentes: a) o aporte teórico advindo de uma disciplina do curso de mestrado em Educação chamada Seminário Docência no Ensino Superior, b) o aporte teórico advindo leituras para uma pesquisa de mestrado em Educação e c) a prática reflexiva de uma experiência de docência no ensino superior. Ao longo do processo, as reflexões estabelecidas evidenciaram a necessidade de mudanças, no que se refere à postura do docente, diante das incertezas, tanto profissionalmente como nas outras dimensões, modificando o entendimento de que o ideal é a estabilidade e passando a compreender que as ordens e desordens fazem parte do real complexo.
Palavras-chave: docência, ensino superior, incerteza, complexidade.
Burden and Trends of Severe Rotavirus Infections and Allcause Acute Gastroenteritis Hospital Episodes in Children Under Five Years Old in Mainland Portugal
Authors: Lucaccioni Héloïse , Sá Machado Rita 
Published: October 2021

Introduction: Rotavirus infections are a leading cause of severe acute gastroenteritis in children under five years old. In December 2019, Portugal announced the inclusion of the rotavirus vaccine, already available for private purchase, in the National Immunization Program. We present the first nationwide analysis of the burden and trends of rotavirus and acute gastroenteritis hospital episodes in children under five years old in mainland Portugal (2014 - 2017).Material and Methods: We used the hospital morbidity database and the Death Certificate Information System to identify hospital episodes and deaths of rotavirus and acute gastroenteritis based on the codes of the International Classification of Diseases. We described the number and rates of hospital episodes disaggregated by age group, sex, geographical units, and the seasonality and trends over the study period.Results: On average, during the study period, there were 1985 annual hospital episodes among children under five years old. The annual rate was 48.0/10 000 children (95% CI 46.9 - 49.0). Rates were consistently higher in younger children, and 67.8% episodes occurred in children under 24 months. We found a seasonal pattern with a major peak in the early spring.Discussion: Our results were consistent with the current knowledge on rotavirus and acute gastroenteritis hospital episodes in Europe. Additional studies are needed to identify the risk factors and high-risk groups for hospital attendance.Conclusion: Rotavirus and acute gastroenteritis hospital episodes in children under five years old in mainland Portugal represent an important health and economic burden. In the future, monitoring this burden and these trends in relation with rotavirus vaccine coverage could be useful in order to assess the impact of the vaccination programme on the change in hospital episodes.
THE EFFECT OF POPULATION GROWTH AND TRADE OPENNESS ON ECONOMIC GROWTH OF THE OIC COUNTRIES
Authors: Muharromy Noor Syahro El , Auwalin Ilmiawan 
Published: October 2021

ABSTRAKPertumbuhan ekonomi memegang peranan penting dalam menentukan keberhasilan pembangunan sebuah negara, oleh karena itu setiap negara selalu menetapkan target pertumbuhan ekonomi yang stabil dalam tujuan pembangunan. Dalam prosesnya pertumbuhan ekonomi dipengaruhi oleh berbagai factor yang dapat mendorong atau bahkan menghambat laju pertumbuhan. Penelitian ini bertujuan untuk menganalisis pertumbuhan penduduk, keterbukaan perdagangan, inflasi, nilai tukar dan investasi terhadap pertumbuhan ekonomi 40 negara anggota Organisasi Kerjasama Islam (OKI) pada tahun 2005-2019 menggunakan pendekatan kuantitatif dengan teknik analisis regresi data panel fixed effect model dan menggunakan aplikasi Eviews 11dalam mengelola data penelitian. Hasil penelitian ini menunjukkan bahwa variabel pertumbuhan penduduk dan nilai tukar memiliki hubungan signifikan dan negatif terhadap pertumbuhan ekonomi, sedangkan keterbukaan perdagangan dan investasi berpengaruh signifikan dan positif. Sedangkan investasi tidak berpengaruh signifikan pada pertumbuhan ekonomi di Negara OKI. Berdasarkan hasil penelitian ini pemerintah dan pihak terkait diharapkan dapat mengendalikan tingkat pertumbuhan penduduknya serta mendorong sektor perdagangan internasional untuk meningkatkan pertumbuhan ekonomi mengingat tingkat keterbukaan perdagangan di Negara OKI masih dibawah potensinya.Kata Kunci: Pertumbuhan Ekonomi, Pertumbuhan Penduduk, Keterbukaan Perdagangan, Organisasi Kerjasama Islam. ABSTRACTEconomic growth plays an important role in determining the success of a country's development; therefore, each country always sets a target for stable economic growth in its development goals. In the process, economic growth is influenced by various factors that can encourage or even hinder the growth rate. The purpose of this study is to analyze the effect of population growth, trade openness, inflation, exchange rates and investment on the economic growth of 40 member countries of the Organization of Islamic Cooperation (OIC) in 2005-2019 using a quantitative approach with a fixed effect model panel data regression analysis technique and using the Eviews application. 11 in managing research data. The results of this study indicate that the variables of population growth and exchange rates have a significant and negative relationship to economic growth, while trade openness and investment have a significant and positive effect. Meanwhile, investment has no significant effect on economic growth in the OIC Country. Based on the results of this study, the government and related parties are expected to control the rate of population growth and encourage the international trade sector to increase economic growth considering that the level of trade openness in the OIC is still below its potential.Keywords: Economic Growth, Population Growth, Trade Openness, Organization of Islamic Cooperation
Rating algorithm development for assessing the effectiveness of the occupational health and safety management
Authors: Tretiakova L. , Ilchuk O. 
Published: October 2021

Purpose. The purpose of the article is development of a rating algorithm to assess the effectiveness of the occupational health and safety management system at electricity companies. The algorithm aims to determine the ranking scale of enterprises according to standardised safety indicators.
Methodology. There is a certain level of uncertainty on the existing methods for providing and analysing statistical information on accidents, occupational hazards, occupational injuries and occupational diseases. Planning and management tasks are most often carried out when the necessary formal information is insufficient or uncertain. In addition to numerical statistics, information may include other, informal quantities that cannot be measured. Therefore, logical calculations with multivalued logic or ranking rules and investigate the invariance of selection rules for groups of transformations on a finite set of alternatives can be used to handle such knowledge. The formalisation of the ranking problem based on the Copeland method involves the construction of pairwise comparison tables for all formal safety indicators.Obtaining an assessment of the situation occurs with the use of a computer system and a decision support system, which increases the efficiency and accuracy of the assessment of the situation.
Results. A formal apparatus for rating single-type enterprises to assess the effectiveness of the enterprise occupational health and safety management system in the have been developed using intelligent information technologies.
Originality. Based on the Copeland method and the paired comparison method, a safety rating algorithm has been developed, the implementation of which makes it possible to assess the performance of the occupational safety and health system. The results have illustrated the competitive advantage of some enterprises over others and motivate management to take action to improve workplace safety.
Practical value. Formalisation of information on hazardous and harmful occupational factors makes it possible to treat the subject area as a complex dynamic system, consisting of objects of a different nature, the totality of which determines the safety level. The developed rating method allows transferring the obtained results to decision-making support systems, illustrating competitive advantages of some enterprises over others, motivating management to take actions to improve occupational safety.
Оцінка якості виготовлення роз’ємних конструкцій паперово-білової продукції
Authors: Хмілярчук Ольга Іларіонівна , Чепурна Катерина Олександрівна , Клішина Марія Олександрівна 
Published: October 2021

Комплексний показник якості видань з роз’ємними блоками — це характеристика, визначена у кількості декількох факторів, їх властивостей, які визначають якість продукції. Цей показник визначається відповідно до експлуатації та способів виготовлення.
Серед факторів, що впливають на якість виготовлення роз’ємних конструкцій паперово-білової продукції виділено наступні: виготовлення блоку, зошитів, сторінок; обладнання, матеріали, технологія, методи та засоби вимірювання, персонал (економічна зацікавленість, умови праці, кваліфікація та спеціалізація, дисципліна). Проаналізувавши вплив людських ресурсів, розглянуто ранжування факторів ризику. При розгляданні матеріалів як складової фактору виготовлення, було визначено, що на довготривалість виготовлення впливає тип конструкції, складність конструкції (кількість деталей, складність скріплень), час ручних та машинних операцій при брошурувально-палітурних процесах.
В результаті виконаних досліджень проведено загальний аналіз факторів впливу на якість роз’ємних конструкцій паперово-білової продукції, їх ранжування; представлено комплексний показник якості даного виду продукції, розроблено діаграму Ісікави. Згідно із розробленою причинно-наслідковою діаграмою, систематизовано чинники впливу на якість виготовлення роз’ємних конструкцій паперово-білової продукції. Представлена діаграма дозволяє встановити можливі причини отримання браку на всіх етапах виготовлення продукції, провести аналіз причин появи браку та знайти шляхи їх усунення, що в цілому дозволить покращити якість.
За результатами опитування двох експертних груп з користувачів (група 1) та виробників (група 2) продукції встановлено, що дані не завжди корелюються між собою. Погляди користувача та виробника деколи відрізняються. Це спричинено тим, що при виробництві окремим фактором при оцінці виробу до уваги береться технологія виготовлення. Тобто в певних випадках використання того чи іншого матеріалу може бути недоцільним або неможливим. Відповідно продукція, що цікава споживачам, досить часто викликає складнощі в технологічних процесах виготовлення на виробництві.
За результатами проведених досліджень було розроблено алгоритм керування якістю виготовлення роз’ємних конструкцій паперово-білової продукції, чим було сформульовано вимоги до продукції та потреби або очікування користувачів. Якістю визначається ступінь, для якого сукупність характеристик задовольняє вимоги, що призводять до задоволення замовника та його сприйняття ступеня виконання вимог.