bluuebunny/crossref_metadata_2025_split huggingface dataset:
An effect of spinal and ankle-foot orthoses on gait of spastic diplegic child: A case report
Authors: Ziziene Jurgita , Daunoraviciene Kristina , Juskeniene Giedre , Pauk Jolanta 
Published: November 2021

BACKGROUND: In children with spastic cerebral palsy (CP), the most common motor dysfunction is pathological gait. OBJECTIVE: To evaluate the effectiveness of measures for an individual CP case. METHODS: The case of one spastic diplegia child has been analyzed. Both lower extremities and spine were examined under three gait conditions: 1) barefoot, 2) with ankle-foot orthoses (AFOs) and thoracolumbosacral spinal orthosis (TLSO), and 3) with TLSO only. Spatiotemporal gait and kinematic parameters of the pelvic, hip, knee, ankle joints, and spine were obtained using Vicon Plug-in-Gait model. The difference (Δ) between the measured values and normative ranges was calculated to determine the efficiency of the orthoses. RESULTS: Significant differences were found in kinematic and spatiotemporal parameters comparing results between conditions and body sides. The effectiveness of the measures was confirmed by the smallest Δ values in the double and single support time with the AFOs/TLSO and in the stride and stance time with TLSO. CONCLUSIONS: Based on the study results, the best stability of the spine, ankle plantarflexion, and knee hyperextension is achieved with the AFOs/TLSO; therefore, this combination of measures was considered the most effective. However, not only quantitative parameters should be taken into account, but also the child’s willingness and comfort.
2D numerical investigations derived from a 3D dragonfly wing captured with a high-resolution micro-CT
Authors: Stelzer Vera , Krenkel Lars 
Published: November 2021

BACKGROUND: Due to their corrugated profile, dragonfly wings have special aerodynamic characteristics during flying and gliding. OBJECTIVE: The aim of this study was to create a realistic 3D model of a dragonfly wing captured with a high-resolution micro-CT. To represent geometry changes in span and chord length and their aerodynamic effects, numerical investigations are carried out at different wing positions. METHODS: The forewing of a Camacinia gigantea was captured using a micro-CT. After the wing was adapted an error-free 3D model resulted. The wing was cut every 5 mm and 2D numerical analyses were conducted in Fluent® 2020 R2 (ANSYS, Inc., Canonsburg, PA, USA). RESULTS: The highest lift coefficient, as well as the highest lift-to-drag ratio, resulted at 0 mm and an angle of attack (AOA) of 5∘. At AOAs of 10∘ or 15∘, the flow around the wing stalled and a Kármán vortex street behind the wing becomes visible. CONCLUSIONS: The velocity is higher on the upper side of the wing compared to the lower side. The pressure acts vice versa. Due to the recirculation zones that are formed in valleys of the corrugation pattern the wing resembles the form of an airfoil.
Quantitative assessment of the level of instability of a single-plane balance platform
Authors: Gudziunas Vaidotas , Domeika Aurelijus , Puodžiukynas Linas , Gustiene Renata 
Published: November 2021

BACKGROUND: Balance training on unstable surfaces is widely used in medicine and sports. The main disadvantage of balance platforms is weakly definable assessment of the level of instability (IL) they create. OBJECTIVE: To evaluate the mechanical characteristics of a suspended single-plane instability balance platform which determines quantitative instability characteristics. METHODS: Three criteria influencing the IL were evaluated: 1. The displacement of the platform board by changing the position of the object on the board; 2. Amount of force required for board displacement; 3. The vibration damping of the platform. RESULTS: 1. 1IL the displacement of the object on the board affected 0.66 cm. the displacement of the board relative to the platform frame; 2IL – 0.79 cm; 3IL – 0.91 cm.; 2. A force of 2.64 is required for a board displacement of 1IL compared to 2IL and 5.76 times that of 3IL. 3. Damping factor 1IL – 0.015, 2IL – 0.006, 3IL – 0.003. CONCLUSIONS: 1. The longer the suspension, the change in the position of the object on the board affects the greater movement of the board relative to the platform. 2. Different IL can be compared with each other depending on how different the force required to cause the board to move. 3. The platform dampens vibrations weakly, but the damping between 1 and 3 IL differs about 5 times.
IbM “PENDEKKAR BIMA” (Pendidikan Kesehatan Kader Dan Remaja Berbasis Masyarakat ) sebagai penguatan kinerja melalui pelatihan pemeriksaan darah di Posyandu Jambu Desa Bogoran
Authors: Estri Belian Anugrah 
Published: November 2021

Kegiatan ini memaparkan hasil pelaksanaan Iptek bagi Masyarakat (IbM) dalam bentuk pendidikan kesehatan kader dan remaja berbasis masyarakat ) sebagai penguatan kinerja melalui pelatihan pemeriksaan darah di posyandu jambu desa Bogoran. Tujuan program ini menumbuhkan kepedulian remaja dalam kesehatan di masyarakat salah satunya kesehatan lansia, serta menggerakkan peran aktif dan mandiri dari kader lansia dalam pemeriksaan darah kolestrol, asam urat, dll. Target Luaran yang dihasilkan adalah 10 peserta pelatihan yang terdiri remaja pkk dan kader posyandu lansia yang telah aktif dalam mengikuti pelatihan pemeriksaan darah kolesterol, asam urat, glukosa darah dan hb. Diharapkan dengan partisipasi aktif ini akan menumbuhkan semangat kader dalam memberikan pelayanan di masyarakat serta membentuk kemandirian kader dalam deteksi dini penyakit yang sering dialami lansia. Sebagai tindak lanjut dari kegiatan ini diharapkan mampu memberikan pelayanan dengan baik dan mandiri dalam peningkatan kesehatan lansia, serta melalui etos kerja kader MAU belajar dan harus MAMPU melakukan peningkatan kesehatan di masyarakat salah satunya dengan ketrampilan pemeriksaan darah ini.
COMPARATIVE EVALUATION OF EFFICACY OF SCALING AND ROOT PLANING WITH AND WITHOUT CHLORHEXIDINE CHIP AND DIODE LASER IN CHRONIC PERIODONTITIS PATIENTS
Authors: Shree Reya , Dahiya Varun , Shukla Pradeep , Kataria Prerna , Dagar Mona 
Published: November 2021

Introduction: The motive of the present study is to comparatively measure the competence and effectiveness of diode laser and chlorhexidine chip as adjuncts to the scaling and root planing procedure, in patients with chronic periodontitis.
Aim: To evaluate the efficacy of diode laser and chlorhexidine chip before and after scaling and root planing in the management of chronic periodontitis. The objective is to compare the efficacy of chlorhexidine chip and diode laser before and after scaling and root planning on clinical parameters.
Study and design: Randomized clinical trial with split mouth design done in the Department of Periodontics and Implantology.
Materials and methods: Twenty chronic periodontitis patients having a probing pocket depth of 5mm-7mm on at least one interproximal site in each quadrant of the mouth were selected in the study. After initial treatment, four sites in each patient were randomly subjected to scaling and root planing (control), chlorhexidine chip application (CHX chip group), diode laser (810 nm) decontamination (Diode laser group) or combination of both (Diode laser and chip group). All subjects received a clinical periodontal examination by single examiner who recorded all the variables by manual procedure. Clinical parameters namely Plaque index (PI), Gingival Index (GI), probing pocket depth (PPD) and clinical attachment level (CAL) were assessed at baseline, one month and three months. Results were statistically analysed using one-way ANOVA followed by Post Hoc Analysis.
Results: The differences in PPD reduction and CAL gain between control group and CHX chip and combination groups were statistically significant (p<0.05) at three months, whereas, the diode laser group did not show any significant difference from the control group.
Conclusion: Within the limitations in the present study, the following conclusions were derived, i.e., chlorhexidine local delivery alone or in combination with diode laser decontamination is effective in improving oral hygiene, reducing gingival inflammation, reducing probing pocket depth and improving clinical attachment levels when used as adjuncts to scaling and root planing in non-surgical periodontal therapy of patients with chronic periodontitis.
Keywords: Diode laser decontamination, Local drug delivery, Scaling and root planing.
Efektifitas Hypnopregnancy Terhadap Peningkatan Kualitas Tidur Ibu Hamil
Authors: Maya Raden Ayu Aminah , Rosmiarti Rosmiarti 
Published: November 2021

Latar Belakang: Selama kehamilan, tubuh ibu hamil mengalami perubahan besar yang bias membuat ibu hamil seringkali merasa tidak nyaman, baik itu perubahan fisiologis maupun psikologis. Perubahan ini menimbulkan gejala spesifik sesuai dengan tahapan kehamilan yang terdiri dari tiga trimester. Perubahan psikologis yang sering terjadi pada ibu hamil seperti kecemasan/ stress. Dampak kecemasan yang lain adalah dapat menurunkan kualitas dan kuantitas tidur ibu hamil selama masa kehamilan Terapi non farmakologi yang dapat dilakukan meliputi relaksasi,guided imagery, progressive muscle relaxation, hipnoterapi dan terapi music klasik. Tujuan: Penelitian ini untuk mengetahui efektifitas hypnopregnancy dalam meningkatkan kualitas tidur ibu. Metode: penelitian ini adalah penelitian quasi eksperiment dengan bentuk rancangan perbandingan kelompok statis (Static Group Comparison) dan menggunakan uji statistik chi square. Data didapatkan dari wawancara melalui lembar observasi langsung dengan instrument The Pittsburgh Sleep Quality Index (PSQI). Sampel penelitian ini berjumlah 30 orang yang terdiri dari kelompok eksperimen dan kontrol. Hasil:uji statistik, diperoleh tingkat signifikansi ρ<0.05 (ρ: 0.009), yang berarti ada pengaruh yang signifikan antara hypnopreganncy terhadap kualitas tidur ibu hamil.Kesimpulan:hypnopregnancy dapat digunakan sebagai salah satu terapi untuk memperbaiki dan meningkatkan kualitas tidur ibu.
Immobilized Fe3O4-Polydopamine-Thermomyces lanuginosus Lipase-Catalyzed Acylation of Flavonoid Glycosides and Their Analogs: An Improved Insight Into Enzymic Substrate Recognition
Authors: Wang Zhaoyu , Li Yang , Li Mingyi , Zhang Xiaohui , Ji Qingxia , Zhao Xiaojuan , Bi Yanhong , Luo Si 
Published: November 2021

The conversion of flavonoid glycosides and their analogs to their lipophilic ester derivatives was developed by nanobiocatalysts from immobilizing Thermomyces lanuginosus lipase (TLL) on polydopamine-functionalized magnetic Fe3O4 nanoparticles (Fe3O4-PDA-TLL). The behavior investigation revealed that Fe3O4-PDA-TLL exhibits a preference for long chain length fatty acids (i.e., C10 to C14) with higher reaction rates of 12.6–13.9 mM/h. Regarding the substrate specificity, Fe3O4-PDA-TLL showed good substrate spectrum and favorably functionalized the primary OH groups, suggesting that the steric hindrances impeded the secondary or phenolic hydroxyl groups of substrates into the bonding site of the active region of TLL to afford the product.
A New Ferroptosis-Related lncRNA Signature Predicts the Prognosis of Bladder Cancer Patients
Authors: Chen Mei , Nie Zhenyu , Li Yan , Gao Yuanhui , Wen Xiaohong , Cao Hui , Zhang Shufang 
Published: November 2021

Background: Ferroptosis is closely related to the occurrence and development of cancer. An increasing number of studies have induced ferroptosis as a treatment strategy for cancer. However, the predictive value of ferroptosis-related lncRNAs in bladder cancer (BC) still need to be further elucidated. The purpose of this study was to construct a predictive signature based on ferroptosis-related long noncoding RNAs (lncRNAs) to predict the prognosis of BC patients.Methods: We downloaded RNA-seq data and the corresponding clinical and prognostic data from The Cancer Genome Atlas (TCGA) database and performed univariate and multivariate Cox regression analyses to obtain ferroptosis-related lncRNAs to construct a predictive signature. The Kaplan-Meier method was used to analyze the overall survival (OS) rate of the high-risk and low-risk groups. Gene set enrichment analysis (GSEA) was performed to explore the functional differences between the high- and low-risk groups. Single-sample gene set enrichment analysis (ssGSEA) was used to explore the relationship between the predictive signature and immune status. Finally, the correlation between the predictive signature and the treatment response of BC patients was analyzed.Results: We constructed a signature composed of nine ferroptosis-related lncRNAs (AL031775.1, AL162586.1, AC034236.2, LINC01004, OCIAD1-AS1, AL136084.3, AP003352.1, Z84484.1, AC022150.2). Compared with the low-risk group, the high-risk group had a worse prognosis. The ferroptosis-related lncRNA signature could independently predict the prognosis of patients with BC. Compared with clinicopathological variables, the ferroptosis-related lncRNA signature has a higher diagnostic efficiency, and the area under the receiver operating characteristic curve was 0.707. When patients were stratified according to different clinicopathological variables, the OS of patients in the high-risk group was shorter than that of those in the low-risk group. GSEA showed that tumor- and immune-related pathways were mainly enriched in the high-risk group. ssGSEA showed that the predictive signature was significantly related to the immune status of BC patients. High-risk patients were more sensitive to anti-PD-1/L1 immunotherapy and the conventional chemotherapy drugs sunitinib, paclitaxel, cisplatin, and docetaxel.Conclusion: The predictive signature can independently predict the prognosis of BC patients, provides a basis for the mechanism of ferroptosis-related lncRNAs in BC and provides clinical treatment guidance for patients with BC.
Rapid Gelling of Guar Gum Hydrogel Stabilized by Copper Hydroxide Nanoclusters for Efficient Removal of Heavy Metal and Supercapacitors
Authors: Zhu Xinwei , Chen Yingxi , Xie Renjian , Zhong Haijian , Zhao Weidong , Liu Yang , Yang Hui 
Published: November 2021

In this paper, guar gum (GG) hydrogel has been successfully prepared by adding GG and Cu2+ mixture into an alkaline medium. The formation mechanism of the hydrogel has been investigated through various techniques. Results reveal GG facilitates the formation of ultrafine copper hydroxide clusters with a diameter of ∼3 nm. Moreover, these nanoclusters bring about a rapid gelling of GG within 10 ms. The synthesized hydrogel is applied to the adsorption of heavy metal ions from wastewater. The hydrogel shows excellent removal efficiency in removing various heavy metal ions. Besides, the hydrogel derived porous carbon exhibits high specific capacitance (281 F/g at 1 A/g) and excellent rate capacity. The high contaminant removal efficiency character and excellent electrochemical performance endow GG hydrogel with potential applications in the environmental and energy storage field.
Prognostic Potential of Liver Enzymes in Patients With COVID-19 at the Leishenshan Hospital in Wuhan
Authors: Liu Zeming , Hu Di , Li Jinpeng , Xia Qing , Gong Yan , Li Zhengwei , Wu Qian , Yi Meilin , Huang Yihui , Wu Meng , Guo Liang , Wu Xiaohui 
Published: November 2021

BackgroundCoronavirus disease 2019 (COVID-19) has evolved into a pandemic. We hypothesized that biochemical indicators of liver function may help determine the prognosis of COVID-19 patients.MethodsPatient information was collected from the Wuhan-Leishenshan hospital. Logistic and Cox regression analyses, Kaplan-Meier curves, and Curve fitting were used to determine the correlation between elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), and AST/ALT and severity of disease/mortality.ResultsLogistic and Cox regression analyses and Kaplan-Meier survival curves showed that COVID-19 progression correlated with elevated levels of AST and AST/ALT. The odds ratios for elevated levels of AST and AST/ALT in patients were 0.818 (95% confidence interval [CI]: 0.274-2.441, P = 0.035) and 2.055 (95% CI: 1.269-3.327, P = 0.003), respectively; the hazard ratios were 4.195 (95% CI: 1.219-14.422, P = 0.023) and 3.348 (95% CI: 1.57-7.139, P = 0.002), respectively. The Kaplan-Meier survival curves demonstrated that patients with elevated AST and AST/ALT levels had a higher risk of developing severe COVID-19.ConclusionElevated AST and AST/ALT levels correlated with severity of COVID-19 and mortality. Liver function tests may help clinicians in determining the prognosis of patients undergoing treatment for COVID-19.
Bacterial Characteristics of Intestinal Tissues From Patients With Crohn’s Disease
Authors: Sun Desen , Ge Xiaolong , Tang Shasha , Liu Yaxin , Sun Jun , Zhou Yuping , Luo Liang , Xu Zhengping , Zhou Wei , Sheng Jinghao 
Published: November 2021

Background and AimsIt is believed that intestinal bacteria play an indispensable role in promoting intestinal inflammation. However, the characteristics of these tissue-associated bacteria remain elusive. The aim of this study is to explore the bacterial loads, compositions, and structures in the noninflamed mucosa, inflamed mucosa, and creeping fat taken from patients with Crohn’s disease (CD).MethodsNoninflamed mucosa, inflamed mucosa, and creeping fat samples were obtained from 10 surgical patients suffering from CD. Total bacterial DNA was extracted in a sterile environment using aseptic techniques. The V3–V4 regions of bacterial 16S rDNA were amplified and analysed using standard microbiological methods. qPCR was used to confirm the change in abundance of specific species in additional 30 independent samples.ResultsInflamed mucosa exhibited the highest bacterial load (3.8 and 12 times more than that of non-inflamed mucosa and creeping fat) and species diversity. The relative abundance of Proteobacteria was dominant in most samples and was negatively associated with Firmicutes. Moreover, the relative abundances of Methylobacterium and Leifsonia in creeping fat significantly increased more than twice as much as other tissue types. The bacterial community structure analysis showed that the bacterial samples from the same individual clustered more closely.ConclusionThis study reveals the significant differences in bacterial load, species diversity, and composition among different intestinal tissue types of CD patients and confirms that the bacterial samples from the same individual are highly correlated. Our findings will shed light on fully revealing the characteristics of tissue-associated bacteria and their roles in CD pathogenesis.
Administration of Adenosine Triphosphate Provides Additional Value Over Programmed Electrophysiologic Study in Confirmation of Successful Ablation of Atrioventricular Accessory Pathways
Authors: Wei Wei , Fang Xianhong , Shehata Michael , Wang Xunzhang , Zhan Xianzhang , Deng Hai , Liao Hongtao , Liao Zili , Liu Yang , Xue Yumei , Wu Shulin 
Published: November 2021

Objectives: To study the benefit of adenosine triphosphate (ATP) in evaluating ablation endpoints of accessory pathways (AP) and subsequent long-term prognosis.Methods: We reviewed consecutive patients with supraventricular tachycardias due to APs that underwent radiofrequency catheter ablation (RFCA) from January 2016 to September 2018 in our center. The patients were divided into two groups: the ATP group (who had passed both the ATP test and PES after ablation as the endpoint) and the non-ATP group (who had passed PES only after ablation as the endpoint). We reviewed the patients' intra-cardiac electrograms and analyzed their long-term outcomes.Results: In total, 1,343 patients underwent successful RFCA. There were 215 patients in the ATP group with one lost to follow-up. There were 1,128 patients in the non-ATP group with 39 lost to follow-up. Twenty-three patients in the ATP group demonstrated additional electrophysiological entities due to ATP administration, including reappearance of the ablated APs in 16 patients, discovery of PES-undetected APs in 5, induction of atrial fibrillation in 5, premature atrial contractions in 1, and premature ventricular contractions in another. During the 7 to 39 months (average 24.4 ± 9.5 months) follow-up, the recurrence rate was 8.41% (18/214) in the ATP group and 6.80% (74/1,084) in the non-ATP group. In subjects with recurrence, 14 patients (14/18 = 77.8%) in the ATP group and 50 patients (50/74 = 67.6%) in the non-ATP group accepted redo ablations. Among the ATP-group, all the 14 redo APs were the old ones as before. Among the non-ATP-group, redo ablations confirmed that 39 APs were the old ones, while 20 APs were newly detected ones which had been missed previously. The difference in recurrent AP locations confirmed by redo procedures between the two groups was significant (p = 0.008). In the non-ATP group, 20 (40%) of redo cases were proven to have multiple APs, while 33 (3.3%) cases who did not suffer from recurrence had multiple APs. Existences of multiple APs in recurred cases were significantly higher than that in non-recurred ones in the non-ATP group (p &lt; 0.001), while there was no such difference in the ATP group (p = 0.114).Conclusions: The existence of multiple APs was more common in recurrent cases if ATP was not used for confirmation of ablation endpoints. ATP probably has additional value over PES alone by detecting weak AP conductions. ATP can evoke atrial and ventricular arrhythmias.
Study on Blasting Technology for Open-Pit Layering of Complex Mine Adjacent to High and Steep Slope
Authors: Wang Menglai , Li Xiaoshaung , Li Qihang , Hu Yunjin , Chen Qiusong , Jiang Song 
Published: November 2021

In China, mining blasting vibration has seriously threatened the safety and stability of high and steep rock slopes. In this paper, taking the east mining area of Jianshan Phosphorus Mine as the research background, combined with field survey, field blasting test, numerical simulation and theoretical analysis, we systematically studied the adjacent high-steep rock slope and the layered blasting technology of complex ore. Based on wide hole spacing blasting numerical simulation and field tests, the use of 8 × 4 m hole network parameters, oblique line hole-by-hole initiation method, detonator delay using 35 ms between holes, 65 ms between rows and 500 ms within the holes, the rock mass rate was reduced and the drilling workload was decreased. In addition, regression analysis was carried out on a large amount of vibration test data, and the attenuation law and propagation law of blasting vibration of adjacent high and steep slopes were predicted, which provided a reference for mine production blasting. By establishing a mathematical model of cumulative damage of rock mass blasting, it shows that the depth of impact of mining blasting on the slope of Jianshan open-pit was 0–3.6m, but the blasting did not cause overall damage to the adjacent high and steep slopes. In the future, this model can be used to predict rock damage caused by subsequent blasting.