bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic intermittent intravenous immunoglobulin in heart transplant recipients with elevated donor‐specific antibody levels
Authors: Yopes Margot , Fanek Tala , Fuselier Byron , Gaine Maureen , Jackson Ruslana , Mabasa Angelo , Kim Andrea , Jennings Douglas L , Clerkin Kevin , Yuzefpolskaya Melana , Habal Marlena , Latif Farhana , Restaino Susan , Lee Sun Hi , Farr Maryjane , Colombo Paolo , Sayer Gabriel , Uriel Nir 
Published: October 2021

AbstractDonor‐specific antibodies (DSA) are associated with antibody‐mediated rejection (AMR) and poor patient survival. In heart transplant, the efficacy of intermittent intravenous immunoglobulin (IVIg) in reducing de novo DSA levels and treating AMR has not been characterized. We retrospectively studied a cohort of 19 patients receiving intermittent IVIg for elevated DSA and examined changes in DSA levels and graft function. Intermittent IVIg infusions were generally safe and well tolerated. Overall, 23 of 62 total DSA (37%) were undetectable after treatment, 21 DSA (34%) had MFI decrease by more than 25%, and 18 (29%) had MFI decrease by less than 25% or increase. The average change in MFI was ‐51% ± 71% (P < .001). Despite reductions in DSA, among the six patients (32%) with biopsy‐confirmed AMR, left ventricular ejection fraction (LVEF) decreased in five (83%) and cardiac index (CI) decreased in three (50%). Conversely, LVEF increased in 91% and CI increased in 70% of biopsy‐negative patients. All six AMR patients were readmitted during treatment, four for confirmed or suspected rejection. IVIg infusions may stabilize the allograft in patients with elevated DSA and negative biopsies, but once AMR has developed does not appear to improve allograft function despite decreasing DSA levels.
Coastal communities, blue economy and the climate crisis: Framing just disruptions
Authors: Morrissey John 
Published: October 2021

AbstractCurrent framing of the blue economy is problematic and deficient in a number of key aspects, specifically in terms of how resilience and justice are currently understood and applied in blue economy discourse. A more holistic and comprehensive understanding and framing of what a sustainable blue economy is, is required to avoid perpetuation of the ecological and social problems of conventional economic growth. New understandings of blue economy which place justice, resilience, and sustainability centrally are required if the blue economy concept is to retain credibility in the context of ongoing climate disruptions, socio‐economic challenges, and the progressive degradation of coastal ecosystems. The blue economy needs to represent a practical, real‐world solution to these issues for coastal communities striving for sustainability. While ideas of ‘just transition’ have been afforded considerable attention in the literature, here the argument is forwarded for a ‘just disruptions’ approach, underpinned by presentation of a novel framework. The ‘just disruptions’ framework posits that rights‐based and capabilities‐based approaches to justice, including principles of distributive and procedural justice, be applied to inform adaptive and resilience focused responses in coastal zones. Applying these principles in practice, the realities of space, place, scale, and power relations need to be acknowledged and more deliberately considered. Such a framing is urgently required to firmly ground debates on blue growth and blue economy in the imperatives of resilience, and social and ecological sustainability.
Group education on the low FODMAP diet improves gastrointestinal symptoms but neither anxiety or depression in irritable bowel syndrome
Authors: Chan Michele Mun Hei , Zarate‐Lopez Natalia , Martin Lee 
Published: October 2021

AbstractBackgroundThe low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet is an effective dietitian‐led treatment for irritable bowel syndrome (IBS). An increasing demand of IBS patient referrals has warranted group FODMAP education led by specialist dietitians. Psychological co‐morbidities are common in IBS, although how the low FODMAP diet influences psychological outcomes is not understood. The present study aimed to evaluate symptom related outcomes of the diet following group education and assess its effect on psychological profiles.MethodsAn observational, prospective study was conducted in 55 IBS patients who attended FODMAP Restriction and FODMAP Reintroduction group sessions. Data were collected at baseline and follow‐up after FODMAP Restriction and analysed using descriptive and McNemar's tests. Primary outcome was evaluated by IBS Symptom Severity Score (IBS‐SSS). Secondary psychological outcomes included anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) and risk of eating disorder questionnaire (SCOFF).ResultsAfter FODMAP Restriction, 27 of 55 (54%) patients reported clinically relevant symptom improvement, as defined by a reduction in the IBS‐SSS ≥50 points, whereas no differences were recorded in the proportion of patients identified with clinical anxiety (p = 1.000) or clinical depression (p = 0.375). Positively, no increased risk of an eating disorder was observed.ConclusionsThe present study provides data supporting the efficacy of the low FODMAP diet in IBS patients who attended dietitian led group education settings in tertiary care. Clinically significant improvements in gastrointestinal symptoms were observed, although with no impact on clinical levels of anxiety, depression or the risk of an eating disorder.
Multiannual trends of toxic and potentially toxic microalgae (Ostreopsis cf. ovata, Prorocentrum lima, and Coolia monotis) in Sfax coasts (North of Gabes Gulf, Tunisia)
Authors: Malika Moncer , Mounir Ben Brahim , Mabrouka Mahfoudhi , Lamia Dammak Walha , Malika Bel Hassen , Asma Hamza 
Published: October 2021

AbstractDuring the last decades, microalgae communities have presented significant changes in their structure and taxa composition along the Mediterranean littoral shallow waters. Despite numerous studies conducted to characterize these changes at various levels, it has always been very difficult to disentangle the effects of physicochemical factors from the meteorological ones. The main purpose of this work was to evaluate possible changes, over a 17‐year scale (1997–2013), in diversity and abundance of three toxic and potentially toxic microalgae related to changes in environmental parameters on Sfax coasts, a pole of shellfish production in Tunisia. In this 17‐year span, a chronological series of data showed that a clear disparity from one year to another was observed in the abundance of studied species. The distribution of these species has been subjected to a seasonal cycle. The studied microalgae, especially Prorocentrum lima, seem to have significant relationships with many physicochemical and meteorological parameters.
Three‐dimensional petrography of the Tucson meteorite
Authors: Friedrich Jon M. , Weisberg Michael K. , Malecek Lucille C. , Nehru C. E. 
Published: October 2021

AbstractWe use X‐ray microtomography (µCT) and digital data extraction techniques for the three‐dimensional (3‐D) petrographic investigation of the Tucson meteorite. Our results show that the silicate‐free metal regions in Tucson exist as discrete objects surrounded by a continuous silicate‐containing metal “matrix.” Volumetric measurements of the silicate‐free metal regions in Tucson demonstrate that they are akin to the sizes of metallic nodules found in CBa chondrites. Silicate‐free metal regions have bladed or prolate shapes. Nonmetallic minerals in Tucson are predominately equant or prolate in shape. Nonmetallic mineral grains and silicate‐free metal regions in Tucson share a common orientation and are part of a petrofabric composed of a lineation. Any foliation in Tucson is weakly developed. We interpret the petrofabric as being the result of a single event on the Tucson parent body, during which Tucson experienced shearing forces. Our 3‐D petrographic investigation supports the idea that Tucson is an unusual member of the CR chondrite clan.
Firm‐level aggregate corruption and competition: The role of telecommunications infrastructure
Authors: Donou‐Adonsou Ficawoyi , Pradhan Gyan , Basnet Hem C. 
Published: October 2021

AbstractThis study examines the relationship between competition and corruption in the presence of enhanced telecommunications infrastructure. We use firm‐level aggregate data provided by the World Bank Enterprise Surveys and collected between 2006 and 2018. Our fixed‐effects results are two‐fold. First, the number of competing firms increases corruption in developing countries. This result is consistent with the previous literature on the competition‐corruption nexus. Second, corruption decreases as the number of competing firms increases in countries with better information and communication technology endowment. Our results are robust to controlling for endogeneity via the two‐step, feasible efficient generalized method of moments and suggest that e‐governance may help to reduce firm‐level corruption in a competitive environment. Given the negative impact of corruption on investment and growth, developing countries should aim at adopting and using more telecommunications infrastructure, along with the traditional approaches of combatting corruption that are based on enforcing rules of law or building stronger institutions, just to name a few, to boost investment and economic growth.
Synthesis and Properties of Dichlorovinyl Derivatives of Tetrazoles
Authors: Myznikov L. V. , Vorona S. V. , Lyakhov A. S. , Ivashkevich L. S. , Zevatskii Yu. E. 
Published: October 2021

Abstract
1-Substituted 1H-tetrazole-5-thiols and 5-substituted 1H-tetrazoles easily reacted with trichloroethylene to form the corresponding S- and N-dichlorovinyl derivatives, respectively. In the case of 5-substituted 1H-tetrazoles, the reaction led to a mixture of 1- and 2-dichlorovinyltetrazoles. 5-Substituted-2-dichlorovinyltetrazoles are characterized by low thermal stability, but easily enter into the polymerization reaction.
Innovating the conservative management of isolated cervical aplasia
Authors: Pires Rafaela , Neves Ana Raquel , Geraldes Fernanda , Águas Fernanda 
Published: October 2021

Isolated cervical aplasia (ESHRE/ESGE U0C4V0) is a rare condition with an incidence of approximately 1:100,000 births.This congenital malformation of the female genital tract represents an impairment of the outflow tract and is an inevitable cause of infertility. Patients usually present with pelvic pain or haematometra and surgical treatment is needed. Conservative management is the first line of approach, allowing for future fertility. However, complications are not negligible. Choosing the best surgical technique remains controversial as few follow-up studies have been published.We describe a case report of isolated cervical aplasia diagnosed in a 16-year-old patient, managed by a canalisation procedure using a Foley catheter. Following failure of this approach, a levonorgestrel intrauterine system was inserted, which remained efficient after 4 years.This case adds to the few reports of success in the management of this challenging clinical entity and might guide clinicians to avoid non-conservative approaches in young patients.
Cohort study of intervened functionally univentricular heart in England and Wales (2000–2018)
Authors: Hadjicosta Elena , Franklin Rodney , Seale Anna , Stumper Oliver , Tsang Victor , Anderson David R , Pagel Christina , Crowe Sonya , Espuny Pujol Ferran , Ridout Deborah , Brown Kate L 
Published: October 2021

ObjectiveGiven the paucity of long-term outcome data for complex congenital heart disease (CHD), we aimed to describe the treatment pathways and survival for patients who started interventions for functionally univentricular heart (FUH) conditions, excluding hypoplastic left heart syndrome.MethodsWe performed a retrospective cohort study using all procedure records from the National Congenital Heart Diseases Audit for children born in 2000–2018. The primary outcome was mortality, ascertained from the Office for National Statistics in 2020.ResultsOf 53 615 patients, 1557 had FUH: 55.9% were boys and 67.4% were of White ethnic groups. The largest diagnostic categories were tricuspid atresia (28.9%), double inlet left ventricle (21.0%) and unbalanced atrioventricular septal defect (AVSD) (15.2%). The ages at staged surgery were: initial palliation 11.5 (IQR 5.5–43.5) days, cavopulmonary shunt 9.2 (IQR 6.0–17.1) months and Fontan 56.2 (IQR 45.5–70.3) months. The median follow-up time was 10.8 (IQR 7.0–14.9) years and the 1, 5 and 10-year survival rates after initial palliation were 83.6% (95% CI 81.7% to 85.4%), 79.4% (95% CI 77.3% to 81.4%) and 77.2% (95% CI 75.0% to 79.2%), respectively. Higher hazards were present for unbalanced AVSD HR 2.75 (95% CI 1.82 to 4.17), atrial isomerism HR 1.75 (95% CI 1.14 to 2.70) and low weight HR 1.65 (95% CI 1.13 to 2.41), critical illness HR 2.30 (95% CI 1.67 to 3.18) or acquired comorbidities HR 2.71 (95% CI 1.82 to 4.04) at initial palliation.ConclusionAlthough treatment pathways for FUH are complex and variable, nearly 8 out of 10 children survived to 10 years. Longer-term analyses of outcome based on diagnosis (rather than procedure) can inform parents, patients and clinicians, driving practice improvements for complex CHD.
ASCOD Phenotyping of Stroke With Anterior Large Vessel Occlusion Treated by Mechanical Thrombectomy
Authors: Fontaine Louis , Sibon Igor , Raposo Nicolas , Albucher Jean-François , Mazighi Michael , Rousseau Vanessa , Darcourt Jean , Thalamas Claire , Drif Amel , Sommet Agnes , Viguier Alain , Guenego Adrien , Januel Anne-Christine , Calvière Lionel , Menegon Patrice , Bonneville Fabrice , Tourdias Thomas , Albers Gregory W. , Cognard Christophe , Olivot Jean-Marc , Christensen Soren , Mlynash Michael , Chollet François , Barbieux Marianne , Michelozzi Caterina , Tall Philippe , Caparros François , Pouzet Brigitte , Calvas Fabienne , Galitzki Monique , Renou Pauline , Rouanet François , Berge Jerome , Marnat Gauthier , Lucas Ludovic , Coignon Cyrielle , Sagnier Sharmila , Debruxelle Sabrina , Ledure Sylvain 
Published: October 2021

Background and Purpose:
Determining the mechanism of large vessel occlusion related acute ischemic stroke is of major importance to initiate a tailored secondary prevention strategy. We investigated using the atherosclerosis, small vessel disease, cardiac source, other cause, dissection (ASCOD) classification the distribution of the causes of large vessel occlusion related acute ischemic stroke treated by mechanical thrombectomy.

Methods:
This was a predefined substudy of the FRAME (French Acute Multimodal Imaging to Select Patient for Mechanical Thrombectomy). Each patient underwent a systematic etiological workup including brain and vascular imaging, electrocardiogram monitoring lasting at least 24 hours and routine blood tests. Stroke mechanisms were systematically evaluated using the atherosclerosis, small vessel disease, cardiac source, other cause, dissection grading system at 3 months. We defined single potential cause by one cause graded 1 in a single domain, possible cause as a cause graded 1 or 2 regardless of overlap, and no identified cause without grade 1 nor 2 causes.

Results:
A total of 215 patients (mean age 70±14; 50% male) were included. A single potential cause was identified in 148 (69%). Cardio-embolism (53%) was the most frequent, followed by atherosclerosis (9%), dissection (5%) and other causes (1%). Atrial fibrillation accounted for 88% of C1. Overlap between grade 1 causes was uncommon (3%). Possible causes were identified in 168 patients (83%) and 16 (7%) had no cause identified after the initial evaluation.

Conclusions:
Cardio-embolism, especially atrial fibrillation, was the major cause of large vessel occlusion related acute ischemic stroke. This finding emphasizes the yield of paroxysmal atrial fibrillation detection in those patients.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03045146.
The Potential of Co-benefits to Spur Subnational Carbon Pricing in North America: A Qualitative Comparative Analysis
Authors: Stevens Daniela 
Published: October 2021

Abstract
We only partially understand the rise of subnational North American governments as carbon-pricing pioneers because fewer than half of the jurisdictions that consider a carbon-pricing policy (CPP) implement one. This article contributes to the literature on CPPs that relies on political economy dynamics and power relations to explain not only policy outcomes but also the lack thereof. Using a qualitative comparative analysis of fifty-four cases, the article shows that subnational governments that have officially considered a CPP tend to implement it if the visible and local co-benefits of mitigation help them bear the political and economic costs of pricing emissions. Findings also show that the regulation of industries with high risk of carbon leakage does not automatically preclude the enactment of CPPs and that the scope of the policy may be more decisive for implementation.
Imagine Your Crossed Hands as Uncrossed: Visual Imagery Impacts the Crossed-Hands Deficit
Authors: Lorentz Lisa , Unwalla Kaian , Shore David I. 
Published: October 2021

Abstract
Successful interaction with our environment requires accurate tactile localization. Although we seem to localize tactile stimuli effortlessly, the processes underlying this ability are complex. This is evidenced by the crossed-hands deficit, in which tactile localization performance suffers when the hands are crossed. The deficit results from the conflict between an internal reference frame, based in somatotopic coordinates, and an external reference frame, based in external spatial coordinates. Previous evidence in favour of the integration model employed manipulations to the external reference frame (e.g., blindfolding participants), which reduced the deficit by reducing conflict between the two reference frames. The present study extends this finding by asking blindfolded participants to visually imagine their crossed arms as uncrossed. This imagery manipulation further decreased the magnitude of the crossed-hands deficit by bringing information in the two reference frames into alignment. This imagery manipulation differentially affected males and females, which was consistent with the previously observed sex difference in this effect: females tend to show a larger crossed-hands deficit than males and females were more impacted by the imagery manipulation. Results are discussed in terms of the integration model of the crossed-hands deficit.
Development and validation of the disease - specific problems questionnaire for patients with multiple sclerosis
Authors: Dehghani Ali 
Published: October 2021

Abstract
Background
Patients with multiple sclerosis face numerous problems during their lifetime. A self-report measurement of disease - specific problems is required to be developed for patients with multiple sclerosis based on different cultural factors. Accordingly, this can advance our understanding on the disease-specific problems for care planning as well as improving coping ways and quality of life. This study aimed to develop and validate the scale of disease-specific problems of Multiple Sclerosis.

Methods
This was an exploratory sequential mixed method study conducted in three phases. Correspondingly, in the first phase, the concept of disease-specific problems was defined using the content analysis approach in patients with MS. In the second phase, the item pool was generated from the findings of the first phase, and in the third phase, psychometric properties of the scale, including face, content, and construct validity and reliability, were evaluated.

Results
After examining both validity and reliability, 28 items were developed in the final questionnaire. As well, by performing the factor analysis, five factors were revealed as follows: physical problems, psychological problems, emotional problems, family problems, and socio-economic problems. Internal consistency and stability of the questionnaire were calculated as 0.82 and 0.90, respectively, indicating an excellent reliability.

Conclusion
The 28-item questionnaire is valid and reliable for measurement of level of disease - specific problems in Iranian people with MS.
Association of identification of facility and transportation for childbirth with institutional delivery in high priority districts of Uttar Pradesh, India
Authors: Rajvanshi Divya , Anthony John , Namasivayam Vasanthakumar , Dehury Bidyadhar , Banadakoppa Manjappa Ramesh , Prakash Ravi , Chintada Dhanunjaya Rao , Khare Shagun , Avery Lisa , Crockett Maryanne , Isac Shajy , Becker Marissa , Blanchard James , Halli Shiva 
Published: October 2021

Abstract
Background
Timely and skilled care is key to reducing maternal and neonatal mortality. Birth preparedness involves preparation for safe childbirth during the antenatal period to reach the appropriate health facility for ensuring safe delivery. Hence, understanding the factors associated with birth preparedness and its significance for safe delivery is essential. This paper aims to assess the levels of birth preparedness, its determinants and association with institutional deliveries in High Priority Districts of Uttar Pradesh, India.

Methods
A community-based cross-sectional survey was conducted between June–October 2018 in the rural areas of 25 high priority districts of Uttar Pradesh, India. Simple random sampling was used to select 40 blocks among 294 blocks in 25 districts and 2646 primary sampling units within the selected blocks. The survey interviewed 9458 women who had a delivery 2 months prior to the survey. Descriptive statistics were included to characterize the study population. Multivariable logistic regression analyses were performed to identify the determinants of birth preparedness and to examine the association of birth preparedness with institutional delivery.

Results
Among the 9458 respondents, 61.8% had birth preparedness (both facility and transportation identified) and 79.1% delivered in a health facility. Women in other caste category (aOR = 1.24, CI 1.06–1.45) and those with 10 or more years of education (aOR = 1.68, CI 1.46–1.92) were more likely to have birth preparedness. Antenatal care (ANC) service uptake related factors like early registration for ANC (aOR = 1.14, CI 1.04–1.25) and three or more front line worker contacts (aOR = 1.61, CI 1.46–1.79) were also found to be significantly associated with birth preparedness. The adjusted multivariate model showed that those who identified both facility and transport were seven times more likely to undergo delivery in a health facility (aOR = 7.00, CI 6.07–8.08).

Conclusion
The results indicate the need for focussing on marginalized groups for improving birth preparedness. Increasing ANC registration in the first trimester of pregnancy, improving frontline worker contact, and optimum utilization of antenatal care check-ups for effective counselling on birth preparedness along with system level improvements could improve birth preparedness and consequently institutional delivery rates in Uttar Pradesh, India.