bluuebunny/crossref_metadata_2025_split huggingface dataset:
Konservasi Temuan Makam Kuno Keramat dan Perkembangan Islam di Medan
Authors: Sumanti Solihah Titin 
Published: July 2021

<p class="06IsiAbstrak">the purpose of this research is to find out how the distribution of the existence of ancient tombs in the city of Medan, the form of management of ancient tombs in the city of Medan based on the Law of Cultural Heritage No. 11 of 2010, and the contribution of the findings of ancient tombs to the development of Islam in the Village Martubung Medan. The method used is transect walk. This method is carried out as a strategy to map the existence of cultural heritage from the existence of complexes of ancient tombs. His findings that the identification of ancient tombs in the city of Medan, especially in Martubung village, namely the Tomb of Datuk Hasan, Tomb of Datuk Payung, Tomb of Datuk Tongah, Datuk Dadih and Tomb of Datuk Hitam. To maintain the cultural heritage, the government collaborates with local communities to conduct socialization and conservation activities that include physical protection, transfer, excavation and recording, maintenance. The discovery of five ancient Islamic tomb complexes in Martubung Village shows the historical events of the entry and development of Islam in North Sumatra and cultural changes through the process of human adaptation to the environment.</p>
Demokrasi Semu: Politik Pencitraan dalam Bingkai Islam dan Implikasi Terhadap Good Governance
Authors: Fithriyyah Mustiqowati Ummul , Astuti Atika Windi , Umam Muhammad Saiful , Wahyu Ningsih Risma Lutfia 
Published: July 2021

<p> </p><p><strong>PSEUDO DEMOCRACY: </strong></p><p><strong>POLITICAL IMAGING WITHIN ISLAMIC FRAMEWORK AND IMPLICATIONS FOR GOOD GOVERNANCE</strong></p><p>Indonesia, as a Muslim-majority country, weaponizes Islam in politics to win over the voices of Muslims in the country. This method is not allowed to be implemented in Indonesia which adheres to a democratic system. Principally, political imaging is carried out in order to influence society by instilling opinions. Regardless of the purpose of imaging, gaining public trust is way more important rather than just having a good image. Public trust is gained through the credibility of the candidates. The said credibility is achieved when the candidates act in a way that is in line with what they said or promised. Candidates can apply political imagery through good governance to gain public trust without having to accentuate the image of the politicization of Islam. This article aims to see how political imaging should be carried out from an Islamic perspective. The method used to study the problems is qualitative. The result of this study shows that the plurality that exists in Indonesia requires special attention from the government to manage the political religions which can create controversy between religious communities. In order to build an essential democracy in Indonesia and avoid the presence of political power of religious identity in the political arena, every candidate must avoid identity involvement in the electoral arena as a way of avoiding the awakening of identity and its sentiment that occurs in Indonesia.</p>
Judicialização da saúde, acesso a medicamentos e diálogos institucionais
Authors: Rodrigues Daniel Dos Santos , Lima Jordão Horácio da Silva 
Published: July 2021

O artigo buscou examinar os vínculos entre acesso à justiça e a efetividade de um dos aspectos do direito à saúde no Brasil, o acesso a medicamentos, a partir dos votos dos ministros do Supremo Tribunal Federal no Recurso Extraordinário nº 566.741/RN e à luz da compreensão e aplicação das teorias dos diálogos institucionais pela Suprema Corte. Discutiu-se que, de maneira geral, há apenas uma enunciação retórica das teorias dos diálogos institucionais (que valorizam, em regra, as capacidades institucionais de cada Poder e a autocontenção do Poder Judiciário) sem de fato aplicá-la. Nesse sentido é representativo o voto do ministro Luís Roberto Barroso, o qual, apesar de expressamente enunciar a aplicação das teorias dos diálogos, não as aplica para resolver o problema da usurpação das funções da Comissão Nacional de Incorporação de Tecnologias no SUS (CONITEC) pelo Poder Judiciário através dos Núcleos de Apoio Técnico ao Judiciário (NatJus), perpetuando a dissolução do direito constitucional a políticas públicas de saúde em um mero direito subjetivo a medicamentos. Concluiu-se que uma possível e definitiva solução dessa questão passa pelo aperfeiçoamento do accountability sobre o Poder Judiciário, de modo que, entre outras coisas, possa ampliar o compartilhamento das consequências políticas e econômicas de suas decisões com a sociedade.
Lidocaine Inhibited Migration of Non-Small-Cell Lung Cancer A549 Cells via the CXCR4 Regulation
Authors: Xing Baichun , Yang Linlin , Cui Yanan 
Published: July 2021

Abstract
BackgroundLidocaineis a local anestheticthat wildly used in surgical treatment and postoperative medical care for lung cancers.We hypothesized thatlidocaine at clinical plasma concentrationcan inhibit CXCL12/CXCR4 axis regulated cytoskeletal remodeling thereby decrease migration ofNon-small-cell lung cancers (NSLC) cells. MethodsWe determined the effect of lidocaine at clinical plasma concentration on CXCL12-induced cell viability, apoptosis, cell death, monolayer cell wound healing rate, individual cell migration indicators, expression of CXCR4, CD44, and ICAM-1, intracellular Ca2+level, and filamentous actin level alteration of NSLC cells A549 and CXCR4-knocked down A549 cells using CCK-8, Bcl-2 ELISA, Cell death ELISA, wound healing assay, chemotaxis assay, western blotting, QPCR, Fura-2-based intracellular Ca2+assay, and Fluorescein Phalloidin staining respectively.﻿ResultsLidocaine did not affect cell viability, apoptosis, and cell death but inhibited CXCL12-induced migration,intracellular Ca2+ releasing, and filamentous actin increase. Lidocaine decreased expression of CXCR4, increased CD44, but had no effect on ICAM-1. CXCL12induced the increase of CD44 and ICAM-1 but did not affect CD44 in the presence of lidocaine.The knockdown of CXCR4 eliminated all the effects of lidocaine.ConclusionLidocaine at clinical plasma concentrations inhibited CXCL12-induced CXCR4 activation, thereby reduced the intracellular Ca2+-dependent cytoskeleton remodeling, resulting in slower migration of A549 cells.
SARS CoV 2 Nsp5 Protein Causes Acute Lung Inflammation, a Dynamical Mathematical Model
Authors: Bensussen Antonio , Díaz José , Buylla Elena R. Álvarez 
Published: July 2021

Abstract
In the present work we propose a dynamical mathematical model of the lung cells inflammation process in response to SARS-CoV-2 infection. In this scenario, our model suggests that the main protease Nsp5 enhances the inflammatory process by increasing the levels of NF κB, IL-6, Cox2, and PGE2 with respect to a reference state without the virus. This overstimulated immune state becomes autonomous of the signals from other immune cells, and does not shut down by itself neither when the external signals are turned off. Our model suggests that Nsp5 is effectively the switch to start inflammation, the consequent overproduction of the ACE2 receptor, and an important underlying cause of the most severe cases of COVID19.
A Study of Cold Roll Forming Technology and Peak Strain Behavior of Asymmetric Corrugated Channels
Authors: Xu Chuntian , Wei Yifan , Pan Tuo , Chen Jianchao 
Published: July 2021

Abstract
The peak strain (PS) of sheet metal highly affects the process design and the quality of roll formed product. Different from the traditional roll forming technology (RFT) that all the cross section contours of the product are rolled simultaneously, a symmetric RFT is developed with respect to the corrugated channels under the study to avoid defects like tearing, twist and redundant deformations. The behaviors of their peak strains are subsequently simulated with Finite Element (FE), and the effects of three factors of the rolling speed, friction coefficient and the bending angle of roll are analyzed, respectively. Finally, both the rationality of RFT and the accuracy of final rolled product are verified by experiments. Results show that for two roll forming channels at the same time, even under the equal bending angles and the pressures of rolls, their maximum peak strains are also distinguished for their different channel widths. The maximum PS of the narrow channel is significantly larger than that of the wide, and the closer to the middle channel, the greater the PS of the narrow channel, which is on the right of bending angle of the trough. Moreover, the maximum PS is dominant by the friction coefficient and bending angle of the first forming pass. This can provide a reference in the design of RFT and improving the quality of the final rolled corrugated channels.
Fine Particulate Matter Pollution Characteristics and Source Apportionment of Changchun Atmosphere
Authors: Tang Jie , Yang Zhuo , Tui Yue , Wang Ju 
Published: July 2021

Abstract
In order to study the pollution characteristics and main sources of fine particulate matter in the atmosphere of the city of Changchun, PM2.5 samples were collected during the four seasons in 2014, and representative months for each season are January, April, July, and October. Sample collection was carried out on 10 auto-monitoring stations in Changchun, and PM2.5 mass concentration, and its chemical components (including inorganic elements, organic carbon, elemental carbon, and water-soluble ions) were measured. The results show that the annual average mass concentration of PM2.5 in Changchun in 2014 was about 66.77 µg/m3. Organic matter was the highest component in PM2.5, followed by secondary inorganic ions (SNA), mineral dust (MIN), elemental carbon (EC), and trace elements (TE). Positive Matrix Factorization (PMF) results gave seven factors, namely, industrial, biomass- and coal-burning, industrial and soil dust, motor-vehicle, soil and secondary-ion, light-industrial, and hybrid-automotive and -industrial sources in PM2.5, with contributing values of 18.9%, 24.2%, 5.7%, 23.0%, 11.5%, 13.0%, and 3.6%, respectively.
Endosomal Traffic And Glutamate Synapse Activity Are Increased In VPS35 D620N Mutant Knock-In Mouse Neurons, And Resistant To LRRK2 Kinase Inhibition
Authors: Kadgien Chelsie , Kamesh Anusha , Khinda Jaskaran , Cao Li Ping , Fox Jesse , Farrer Mathew J , Milnerwood Austen 
Published: July 2021

Abstract
Vacuolar protein sorting 35 (VPS35) regulates neurotransmitter receptor recycling from endosomes. A missense mutation (D620N) in VPS35 leads to autosomal-dominant, late-onset Parkinson’s disease. Here, we study the basic neurobiology of VPS35 and Parkinson’s disease mutation effects in the D620N knock-in mouse and the effect of leucine-rich repeat kinase 2 (LRRK2) inhibition on synaptic phenotypes. The study was conducted using a VPS35 D620N knock-in mouse that expresses VPS35 at endogenous levels. Protein levels, phosphorylation states, and binding ratios in brain lysates from knock-in mice and wild-type littermates were assayed by co-immunoprecipitation and western blot. Dendritic protein co-localization, AMPA receptor surface expression, synapse density, and glutamatergic synapse activity in primary cortical cultures from knock-in and wild-type littermates were assayed using immunocytochemistry and whole-cell patch clamp electrophysiology. In brain tissue, we confirm VPS35 forms complexes with LRRK2 and AMPA-type glutamate receptor GluA1 subunits, in addition to NMDA-type glutamate receptor GluN1 subunits and D2-type dopamine receptors. Receptor and LRRK2 binding was unaltered in D620N knock-in mice, but we confirm the mutation results in reduced binding of VPS35 with WASH complex member FAM21, and increases phosphorylation of the LRRK2 kinase substrate Rab10, which is reversed by LRRK2 kinase inhibition in vivo. In cultured cortical neurons from knock-in mice, pRab10 is also increased, and reversed by LRRK2 inhibition. The mutation also results in increased endosomal recycling protein cluster density (VPS35-FAM21 co-clusters and Rab11 clusters), glutamate transmission, and GluA1 surface expression. LRRK2 kinase inhibition, which reversed Rab10 hyper-phosphorylation, did not rescue elevated glutamate release or surface GluA1 expression in knock-in neurons, but did alter AMPAR traffic in wild-type cells. The results improve our understanding of the cell biology of VPS35, and the consequences of the D620N mutation in developing neuronal networks. Together the data support a chronic synaptopathy model for latent neurodegeneration, providing phenotypes and candidate pathophysiological stresses that may drive eventual transition to late-stage parkinsonism in VPS35 PD. The study demonstrates the VPS35 mutation has effects that are independent of ongoing LRRK2 kinase activity, and that LRRK2 kinase inhibition alters basal physiology of glutamate synapses in vitro.
Comparison of Patient-reported Outcomes at 1 Year after Injury between Limb Salvage and Amputation: A Prospective Cohort Study
Authors: Kurozumi Taketo , Inui Takahiro , Nakayama Yuhei , Honda Akifumi , Matsui Kentaro , Ishii Keisuke , Suzuki Takashi , Watanabe Yoshinobu 
Published: July 2021

Abstract
Background: Owing to advances in knowledge and technology, salvaging the limbs of patients with severe trauma and injuries is possible. However, severe limb injuries occasionally necessitate amputation because it allows patients to regain their social lives earlier than limb salvaging. Moreover, previous related investigations are retrospective cohort studies or meta-analyses of retrospective studies, and prospective cohort studies of patient-reported outcomes are extremely rare. This single-center, prospective cohort study aimed to compare the patient-reported outcomes at 1 year after injury between limb salvage and amputation and to elucidate whether amputation contributes to early recovery of functionality and quality of life.Methods: We included 47 limbs of 45 patients with severe open fractures of the lower limb and categorized them into limb salvage and amputation groups. They were registered in the Database of Orthopedic Trauma by the Japanese Society for Fracture Repair at our center; data on patient-reported outcomes at 1 year after injury were obtained from this database. The mean patient age was 49.6 years. Patients’ limbs were evaluated using the lower extremity functional scale (LEFS) and Short-Form 8 (SF-8). Early recovery was evaluated using functionality and quality-of-life questionnaires. Nonparametric statistical analyses were conducted.Results: Of the 47 limbs, 34 limbs of 34 patients were salvaged and 13 limbs of 11 patients were amputated. Significant differences were noted between the limb salvage and amputation groups in terms of the LEFS scores (mean: 49.5 vs 33.1, P=0.025) and scores for the mental health component (mean: 48.7 vs 38.7, P=0.003), role–physical component (mean: 42.2 vs 33.3, P=0.026), and mental component summary (mean: 48.2 vs 41.3, P=0.042) of the SF-8. The limb salvage group had better scores than the amputation group. Conclusions: In this study, limb salvage results in better functional and mental health outcomes at 1 year after severe lower limb injury than after amputation. As reconstruction technology has advanced and limb salvaging has become possible, the focus of studies should now be based on the perspective of “how the patient feels”; hence, we believe that the results of this study, which is based on patient-reported outcomes, are meaningful.
Diode physical-limit-bandwidth efficient rectification
Authors: Gyawali Babita , Thapa Samundra Kumar , Barakat Adel , Yoshitomi Kuniaki , Pokharel Ramesh Kumar 
Published: July 2021

Abstract
Generally, a conventional voltage doubler circuit possesses a large variation of its input impedance over the bandwidth, which results in limited bandwidth and low RF-dc conversion efficiency. A basic aspect for designing wideband voltage doubler rectifiers is the use of complex matching circuits to achieve decade and octave impedance and RF-dc conversion efficiency bandwidths. Still, the reported techniques till now have been accompanied by a large fluctuation of the RF-dc conversion efficiency over the operating bandwidth. In this paper, we propose a novel rectification circuit with minimal inter-stage matching that consists of a single short-circuit stub and a virtual battery, which contributes negligible losses and overcomes these existing problems. Consequently, the proposed rectifier circuit achieves a diode physical-limit-bandwidth efficient rectification. In other words, the rectification bandwidth, as well as the peak efficiency, are controlled by the length of the stub and the physical limitation of the diodes.
Impact of The Arylation of N-Bridged Annulated BODIPY Dyes In Photophysical Properties
Authors: Mello Rodrigo Brito , Emery Flavio da Silva 
Published: July 2021

Abstract
Functionalization of BODIPY dyes is commonly used to modulate photophysical properties. Among the chemical modification of these dyes, ring fusion indifferent faces of dipyrromethene cores is gaining attention in the literature, due to the modulation ofemission/absorption properties and fluorophores with increased bright. N-bridged annulated BODIPYs were recently synthesized and shows intense bright and blu shifted emission. However, few examples of substituted compounds are described and none involving arylation with extention of the p-conjugation. In this manuscript, it is shown an optimized method for the synthesis of N-bridged annulated BODIPYs, including arylated derivatives, and the studies of molecular properties. It is also shown that fluorinated aryl substituted N-bridged annulated BODIPYs show high quantum yields and are red-shifted compared to unsubstituted examples. The work open opportunities for application of the new developed compounds as probes.
Learning High-Order Geometric Flow Based on The Level Set Method
Authors: Li Chun , Yang Yunyun , Liang Hui , Wu Boying 
Published: July 2021

Abstract
Recently, the development of deep learning (DL), which has accomplished unbelievable success in many fields, especially in scientific computational fields. And almost all computational problems and physical phenomena can be described by partial differential equations (PDEs). In this work, we proposed two potential high-order geometric flows. Motivation by the physical-information neural networks (PINNs) and the traditional level set method (LSM), we have integrated deep neural networks (DNNs) and LSM to make the proposed method more robust and efficient. Also, to test the sensitivity of the system to different input data, we set up three sets of initial conditions to test the model. Furthermore, numerical experiments on different input data are implemented to demonstrate the effectiveness and superiority of the proposed models compared to the state-of-the-art approach.
A High Resolution Coupled Ocean-atmosphere Simulation of the Regional Climate Over Central America
Authors: Misra Vasubandhu , Jayasankar C. B. 
Published: July 2021

Abstract
This study analyzes a relatively high resolution (15km grid spacing), regional coupled ocean-atmosphere simulation configured over Central America. The simulation is forced with global atmospheric and oceanic reanalysis for a period of 25 years (1986-2010). The spatial resolution and the time period of the Regional Climate Model (RCM) simulation are both unprecedented for the region. The highlights of the RCM simulation include the verifiable seasonal cycle of mesoscale features like the low level jets, the mid-summer drought and the seasonal tropical cyclone activity both in the Pacific and in the Atlantic Oceans. Similarly, the seasonal cycle of the robust surface ocean currents in the eastern Pacific and the Costa Rica Dome is also well captured in the RCM simulation. The RCM simulation also resolves the seasonal cycle of the Panama-Colombia Gyre, the Gulf of Papagayo and the Gulf of Tehuantepec Gyre. In many instances we find the RCM improves upon the global reanalysis forcing the simulation, indicating the potential value of dynamic downscaling. Furthermore, the co-evolving components of the atmosphere and ocean in the RCM is an added benefit to the atmosphere only and ocean only global reanalysis forcing the simulation. However, the model displays significant biases that manifest in precipitation, precipitable water, SST and winds which could potentially be improved.
Health Care Burden And Mortality of Acute On Chronic Liver Failure In Thailand: A Nationwide Population-Based Data
Authors: Chirapongsathorn Sakkarin , Poovorawan Kittiyod , Soonthornworasiri Ngamphol , Pan-ngum Wirichada , Chaiprasert Amnart , Phaosawasdi Kamthorn , Treeprasertsuk Sombat 
Published: July 2021

Abstract
Background: Accurate population-based data are required concerning the rate, economic impact, and long-term outcome from acute on chronic liver failures (ACLF) in hospitalized cirrhosis patients.Objective: We aimed to discover time trends for the epidemiology, economic burden, and mortality of ACLF in Thailand.Methods: We conducted a nationwide, population-based, cohort study which involved all hospitalized cirrhosis patients in Thailand during the period between 2009 and 2013, with data from the National Health Security Office. ACLF was defined by two or more extrahepatic organ failures in cirrhosis patients. Primary outcomes were trends in hospitalizations, hospital costs, together with inpatient mortality. Results The number of ACLF hospitalizations in Thailand doubled between 3,185 in 2009 and 7,666 in 2013. The average cost of each ACLF hospitalization was 3.5-fold higher than for cirrhosis (฿ 61,928 versus ฿ 16,995). The hospital is paid using a diagnosis-related group (DRG) payment system that is only 15% of the average treatment costs (฿ 9,371 from ฿ 61,928). The in-hospital fatality rate was 51% for ACLF while the additional fatality rate was 85% up to 1 year. The ACLF organ failure trends indicated sepsis with septic shock and renal failure as the majority proportion. Age, the number and types of organ failure and male sex were predictors of ACLF death. Conclusions and Relevance Cirrhosis and ACLF both represent substantial and increasing health and economic burdens for Thailand. These data can assist national health care policy stakeholders to target high-risk cirrhosis patients for care.