bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative imaging patterns and intracranial findings in single-suture craniosynostosis: a study from the Synostosis Research Group
Authors: Ravindra Vijay M. , Awad Al-Wala , Baker Cordell M. , Lee Amy , Anderson Richard C. E. , Gociman Barbu , Patel Kamlesh B. , Smyth Matthew D. , Birgfeld Craig , Pollack Ian F. , Goldstein Jesse A. , Imahiyerobo Thomas , Siddiqi Faizi A. , Kestle John R. W. , _ _ 
Published: September 2021

OBJECTIVE
The diagnosis of single-suture craniosynostosis can be made by physical examination, but the use of confirmatory imaging is common practice. The authors sought to investigate preoperative imaging use and to describe intracranial findings in children with single-suture synostosis from a large, prospective multicenter cohort.

METHODS
In this study from the Synostosis Research Group, the study population included children with clinically diagnosed single-suture synostosis between March 1, 2017, and October 31, 2020, at 5 institutions. The primary analysis correlated the clinical diagnosis and imaging diagnosis; secondary outcomes included intracranial findings by pathological suture type.

RESULTS
A total of 403 children (67% male) were identified with single-suture synostosis. Sagittal (n = 267), metopic (n = 77), coronal (n = 52), and lambdoid (n = 7) synostoses were reported; the most common presentation was abnormal head shape (97%), followed by a palpable or visible ridge (37%). Preoperative cranial imaging was performed in 90% of children; findings on 97% of these imaging studies matched the initial clinical diagnosis. Thirty-one additional fused sutures were identified in 18 children (5%) that differed from the clinical diagnosis. The most commonly used imaging modality by far was CT (n = 360), followed by radiography (n = 9) and MRI (n = 7). Most preoperative imaging was ordered as part of a protocolized pathway (67%); some images were obtained as a result of a nondiagnostic clinical examination (5.2%). Of the 360 patients who had CT imaging, 150 underwent total cranial vault surgery and 210 underwent strip craniectomy. The imaging findings influenced the surgical treatment 0.95% of the time. Among the 24% of children with additional (nonsynostosis) abnormal findings on CT, only 3.5% required further monitoring.

CONCLUSIONS
The authors found that a clinical diagnosis of single-suture craniosynostosis and the findings on CT were the same with rare exceptions. CT imaging very rarely altered the surgical treatment of children with single-suture synostosis.
A multicenter analysis of the prognostic value of histone H3 K27M mutation in adult high-grade spinal glioma
Authors: Akinduro Oluwaseun O. , Garcia Diogo P. , Higgins Dominique M. O. , Vivas-Buitrago Tito , Jentoft Mark , Solomon David A. , Daniels David J. , Pennington Zach , Sherman Wendy J. , Delgardo Mychael , Bydon Mohamad , Kalani Maziyar A. , Zanazzi George , Tsankova Nadejda , Bendok Bernard R. , McCormick Paul C. , Sciubba Daniel M. , Lo Sheng-fu Larry , Clarke Jennifer L. , Abode-Iyamah Kingsley , Quiñones-Hinojosa Alfredo 
Published: September 2021

OBJECTIVE
High-grade spinal glioma (HGSG) is a rare but aggressive tumor that occurs in both adults and children. Histone H3 K27M mutation correlates with poor prognosis in children with diffuse midline glioma. However, the role of H3 K27M mutation in the prognosis of adults with HGSG remains unclear owing to the rarity of this mutation, conflicting reports, and the absence of multicenter studies on this topic.

METHODS
The authors studied a cohort of 30 adult patients with diffuse HGSG who underwent histological confirmation of diagnosis, surgical intervention, and treatment between January 2000 and July 2020 at six tertiary academic centers. The primary outcome was the effect of H3 K27M mutation status on progression-free survival (PFS) and overall survival (OS).

RESULTS
Thirty patients (18 males and 12 females) with a median (range) age of 50.5 (19–76) years were included in the analysis. Eighteen patients had H3 K27M mutation–positive tumors, and 12 had H3 K27M mutation–negative tumors. The median (interquartile range) PFS was 3 (10) months, and the median (interquartile range) OS was 9 (23) months. The factors associated with increased survival were treatment with concurrent chemotherapy/radiation (p = 0.006 for PFS, and p ≤ 0.001 for OS) and American Spinal Injury Association grade C or better at presentation (p = 0.043 for PFS, and p < 0.001 for OS). There were no significant differences in outcomes based on tumor location, extent of resection, sex, or H3 K27M mutation status. Analysis restricted to HGSG containing necrosis and/or microvascular proliferation (WHO grade IV histological features) revealed increased OS for patients with H3 K27M mutation–positive tumors (p = 0.017).

CONCLUSIONS
Although H3 K27M mutant–positive HGSG was associated with poor outcomes in adult patients, the outcomes of patients with H3 K27M mutant–positive HGSG were somewhat more favorable compared with those of their H3 K27M mutant–negative HGSG counterparts. Further preclinical animal studies and larger clinical studies are needed to further understand the age-dependent effects of H3 K27M mutation.
Use of an intraoperative sodium oxychlorosene–based infection prevention protocol to safely decrease postoperative wound infections after spine surgery
Authors: Alentado Vincent J. , Berwanger Robert P. , Konesco Anabel M. , Potts Alex J. , Potts Caroline A. , Stockwell David W. , Dbeibo Lana , DePowell John J. , Horn Eric M. , Khairi Saad A. , McCanna Shannon P. , Mobasser Jean-Pierre , Rodgers Richard B. , Potts Eric A. 
Published: September 2021

OBJECTIVE
Postoperative infection remains prevalent after spinal surgical procedures. Institutional protocols for infection prevention have improved rates of infection after spine surgery. However, prior studies have focused on only elective surgical patients. The aim of this study was to determine the efficacy of a multiinstitutional intraoperative sodium oxychlorosene–based infection prevention protocol for decreasing rate of infection after instrumented spinal surgery.

METHODS
A retrospective analysis was performed at two tertiary care institutions with level I trauma programs, and patients who underwent posterior instrumented spinal fusion between January 1, 2011, and May 31, 2019, were included. Postoperative deep wound infection rates were captured before and after implementation of a multiinstitutional infection prevention protocol. Possible adverse outcomes related to infection prevention techniques were also examined. In addition, consecutive patients treated from January 1, 2018, to May 31, 2019, were prospectively included in a database to collect preoperative and postoperative spine-specific quality of life measures and to assess the impact of postoperative infection on quality of life.

RESULTS
A total of 5047 patients fit the inclusion criteria. Of these, 1043 patients underwent surgery prior to protocol implementation. The infection rate of this cohort (3.5%) decreased significantly after protocol implementation (1.2%, p < 0.001). Postoperative sterile seroma rates did not differ between the preprotocol and postprotocol groups (0.7% vs 0.7%, p = 0.5). In the 1031 patients who underwent surgery between January 2018 and May 2019, the fusion rate was 89.2%. Quality of life outcomes between patients with infection and those without infection were similar, although statistical power was limited owing to the low rate of infection. Notably, 2 of 10 patients who developed deep wound infection died of infection-related complications.

CONCLUSIONS
An intraoperative sodium oxychlorosene–based infection prevention protocol helped to significantly decrease the rate of infection after spine surgery without negatively impacting other postoperative procedure-related metrics. Postoperative wound infection may be associated with higher-than-expected rate of postoperative mortality.
The novel prognostic value of postoperative follow-up lateral spread response after microvascular decompression for hemifacial spasm
Authors: Cho Minjae , Ji So Young , Go Kyeong-O , Park Kyung Seok , Kim Jong-Min , Jeon Young-Tae , Ryu Jung-Hee , Park Sanghon , Han Jung Ho 
Published: September 2021

OBJECTIVE
The lateral spread response (LSR) is an aberrant electrophysiological response in which a stimulus on one branch of the facial nerve spills over to other branches of the nerve, which can be captured by electrodes near each branch. The authors performed this study to evaluate the prognostic value of the follow-up LSR with a sufficient time interval from intraoperative LSR (IO-LSR) after microvascular decompression (MVD) for hemifacial spasm (HFS), excluding the interference of various intraoperative situations.

METHODS
A total of 247 patients treated with MVD for HFS between June 2011 and March 2019 were enrolled in this study. The IO-LSR was routinely evaluated in all patients. The LSR was checked again on postoperative day (POD) 2 after surgery (POD2-LSR). A total of 228 patients (92.3%) were considered cured at the last clinical follow-up.

RESULTS
The IO-LSR disappeared in 189 patients (76.5%), and among them, 181 patients (95.8%) were cured 1 year after surgery. The POD2-LSR disappeared in 193 patients (78.1%), and 185 patients (95.9%) among them were cured. Among the 189 patients in which the IO-LSR disappeared, the POD2-LSR reappeared in 26 patients (13.8%). In contrast, the POD2-LSR disappeared in 30 (51.7%) of 58 patients for whom the IO-LSR continued at the end of surgery. When classified into groups according to the status of the IO-LSR and POD2-LSR, in the group of patients in whom both LSRs disappeared, the cure rate was 98.2%, which was significantly higher than that of the other 3 groups (p < 0.05, Cochran-Armitage trend test). The use of both LSRs was found to be significantly associated with better predictability (p < 0.05, McNemar’s test).

CONCLUSIONS
Postoperative follow-up LSR examination may be beneficial in predicting clinical outcomes after MVD for HFS, especially when considered together with IO-LSR.
Targeting of cyclin-dependent kinases in atypical teratoid rhabdoid tumors with multikinase inhibitor TG02
Authors: Ding Andy S. , Huq Sakibul , Casaos Joshua , Raj Divyaansh , Morales Manuel , Zhao Tianna , Kim Timothy , Srivastava Siddhartha , Pant Ayush , Serra Riccardo , Gorelick Noah L. , Brem Henry , Tyler Betty 
Published: September 2021

OBJECTIVE
Atypical teratoid rhabdoid tumors (ATRTs) are aggressive pediatric brain tumors with no current standard of care and an estimated median patient survival of 12 to 18 months. Previous genetic analyses have implicated cyclin D1 and enhancer of zeste homolog 2 (EZH2), a histone methyltransferase that is implicated in many cancers, as key drivers of tumorigenicity in ATRTs. Since the effects of EZH2 and cyclin D1 are facilitated by a host of cyclin-dependent kinases (CDKs), the authors sought to investigate the potential therapeutic effects of targeting CDKs in ATRTs with the multi–CDK inhibitor, TG02.

METHODS
Human ATRT cell lines BT12, BT37, CHLA05, and CHLA06 were selected for investigation. The effects of TG02 on cell viability, proliferation, clonogenicity, and apoptosis were assessed via Cell Counting Kit-8 assays, cell counting, clonogenic assays, and flow cytometry, respectively. Similar methods were used to determine the effects of TG02 combined with radiation therapy (RT) or cisplatin. Synergism indices for TG02-cisplatin combination therapy were calculated using CompuSyn software.

RESULTS
TG02 was observed to significantly impair ATRT cell growth in vitro by limiting cell proliferation and clonogenicity, and by inducing apoptosis. TG02 inhibited ATRT cell proliferation and decreased cell viability in a dose-dependent manner with nanomolar half maximal effective concentration (EC50) values (BT12, 207.0 nM; BT37, 127.8 nM; CHLA05, 29.7 nM; CHLA06, 18.7 nM). TG02 (150 nM) dramatically increased the proportion of apoptotic ATRT cells 72 hours posttreatment (TG02 8.50% vs control 1.52% apoptotic cells in BT12, p < 0.0001; TG02 70.07% vs control 15.36%, p < 0.0001). Combination therapy studies revealed that TG02 acted as a potent radiosensitizer in ATRT cells (BT12 surviving fraction, RT 51.2% vs RT + TG02 21.7%). Finally, CompuSyn analysis demonstrated that TG02 acted synergistically with cisplatin against ATRT cells at virtually all therapeutic doses. These findings were consistent in cell lines that cover all three molecular subgroups of ATRTs.

CONCLUSIONS
The results of this investigation have established that TG02 is an effective therapeutic against ATRTs in vitro. Given the lack of standard therapy for ATRTs, these findings help fill an unmet need and support further study of TG02 as a potential therapeutic option for patients with this deadly disease.
Men with paraphilic interests and their desire to interact with a sex robot
Authors: Marečková Alena , Androvičová Renáta , Bártová Klára , Krejčová Lucie , Klapilová Kateřina 
Published: September 2021

Sex robots may present an opportunity for a clinical management of individuals with paraphilic interests whose realisation would result in infliction of harm and/or legal consequences. We explored the prevalence of desire for sex robot experience in a control group and two target groups: one with paraphilic interests in minors, the other with interest in non-consent/violence. We expected both target groups to express a greater desire for sex robot experience than the control group, because sex robots would enable them to express paraphilic sexuality within legal limitations. We used data from two samples of male respondents. The control sample consisted of respondents from a representative online Czech sample (N = 806). Target groups of individuals with paraphilic interests consisted of 48 subjects sexually interested in minors and 57 subjects sexually interested in non-consent/violence against adults. Sex robot experience was desired by 18% of respondents in the control group, 37.5% of respondents in the group interested in minors, and 26% of respondents interested in non-consent/violence. This indicates that individuals with paraphilic interest in minors are slightly more open to the idea of sex robot experience. Studies exploring preferred features of sex robots and interest in their use in therapy are needed.
Pemanfaatan Social Media Marketing dan Penyusunan Laporan Keuangan Koperasi Kampung Bunga Kayu Cilember Mekar di Desa Cilember - Kabupaten Bogor
Authors: Mariam Iis 
Published: September 2021

Pelaksanaan pengabdian kepada Masyarakat akan diadakan di desa Cilember Cisarua Pemerintah Kabupaten Bogor – Jawa Barat tahun ini merupakan tahun keempat sejak tahun 2016 pertama kali dilaksanakan menginat pengabdian kepada masyarakat merupakan wujud dari pelaksanaan Tri Dharma Perguruan Tinggi yang wajib dilaksanakan oleh dosen dibantu oleh staf administrasi dan mahasiswa. Pengabdian masyarakat akan dilaksanakan dengan pembekalan secara teori dan praktek. Adapun kegiatan pengabdian masyarakat memberikan pelatihan mengenai pemasaran produk dilakukan secara online (social media marketing), menyusun laporan keuangan Koperasi Kampung Bunga Kayu Cilember Mekar di Desa Cilember, Kabupaten Bogor dan komunikasi serta pelayanan prima yang dilakukan aparatur desa. Kegiatan pengabdian ini dilaksanakan pada tanggal 18 September 2019, setelah pelaksanaan pengabdian ini selesai akan dilakukan monitoring terhadap hasil dari kegiatan pengabdian pada masyarakat apakah sudah diimplementasikan sesuai prosedur yang berlaku. Tujuan dari kegiatan pengabdian kepada masyarakat adalah untuk memberikan pengetahuan kepada aparat desa Cilember dan masyarakat/pedagang yang menjadi anggota Koperasi Kampung Bunga Kayu di desa Cilember, kabupaten Bogor agar mengetahui cara memasarkan produknya dengan menggunakan social media marketing, memberikan pelayanan yang prima dengan komunikasi yang baik serta mampu membuat laporan keuangan koperasi dengan benar.
Not Strictly STEAM
Authors: Appler Vivian 
Published: September 2021

“That which We Call A Rose,” (“Rose”) is a multi-media performance-as-research project, with puppets and robots, that I devised with a diverse ensemble of undergraduates and professionals to explore questions about planetary nomenclature, climate change, and colonization. “Rose” explicitly challenges andro-and euro-centric hegemonies embedded in 21st century space exploration and invites its audiences to do the same. STEAM (Science, Technology, Engineering, Arts, and Mathematics) has become a popular pedagogy for K-12 education. Many K-12 STEAM programs claim to put art at the heart of STEM, but often prioritize science content over creative process, falling short of the potential that STEAM holds to foster lifelong learners and innovators who are curious, skilled, and literate across a variety of disciplinary and cultural boundaries. The Rhode Island School of Design (RISD), on the other hand, promotes a K-20 STEAM pedagogy that acknowledges the importance of facilitating young learners’ creative inquiry as well as the potential for mature artists to become equally-valued culture creators across arts, science, and social domains.
In this article, I use “Rose” as a case study to query the possibilities of implementing performance-as-research as an essential component of STEAM pedagogies. I examine the ways that artists can invite audiences across multiple social identities to join in processes of performance creation as a means of critical inquiry of STEM fields. The performance-as-research process encourages participant audiences to authentically engage in arts practices as a means of actively combatting social issues such as climate change, professional gender and racial inequity, and the colonialist traditions implicit to contemporary space exploration.
Construct validity of Rosenberg Self-esteem Scale in Brazilian Athletic Context
Authors: Da Silva Walan Robert , Thiago Thiago Emannuel Medeiros , Pesca Andréa Duarte , Cardoso Fernando Luiz 
Published: September 2021

Objective: The purpose of this study was to evaluate the psychometric properties of the Rosenberg Self-esteem Scale in the athletic context of Brazil.
Method: In total, 387 athletes participated in the study, 232 men and 155 women, with a mean age of 22.1+/-4.5 years, practitioners of team modalities in clubs in Southern Brazil. The construct validity was evaluated through exploratory Factorial Analyses with Oblimin Rotation and the factorial weight 0.3 was used to exclude items. Cronbach’s Alpha and Polychoric Correlation evaluated the internal variance consistency.
Results: The Rosenberg Self-esteem Scale uploaded on 2 factors showed 61% of the variance of the construct, with factor 1 adding items about positive self-esteem and factor 2 about negative self-esteem. To confirm the internal consistency of the instrument, we performed polychoric correlation between the items on the scale. All items showed significant positive correlation above 0.3 (p>0.05) confirming the good internal consistency of the questionnaire.
Conclusion: This research identifies good psychometric properties of the Rosenberg Self-esteem Scale in the Brazilian sport context of athletes of team sports. The bifactorial structure was verified, agreeing with the original proposal, suggesting the separate score calculation of each factor on the self-esteem Scale.
Blood glucose threshold of the inspiratory muscles: is it possible to determine it by Borg?
Authors: Petto Jefferson , Silva Wasly Santana , Santos-Mestre William , Celestino-da-Silva Vitor , Oliveira-de-Oliveira Francisco-Tiago 
Published: September 2021

Objective: To test the hypothesis that it is possible to estimate the glycemic threshold (GT) of inspiratory muscles using the subjective perception scale to Borg's effort.
Methods: Observational association and cross-sectional study, in which 21 male individuals, eutrophic, irregularly active, aged between 18 and 30 years evaluated. All submitted to an incremental inspiratory muscle test to determine the GT. During the test, the traditional Borg scale was applied at each stage of the test. Pearson's test was used to verify the correlation between GT and Borg.
Results: A descriptive analysis that GT occurred 23±9.1% of MIP in an absolute load of 32±14.6cmH2O and was compatible with the score of 13±1.5 on the BORG scale (r=0.67) and (r=0.58) respectively.
Conclusions: Our results provide evidence that the Borg scale is a viable method to determine the GT of inspiratory muscles and consequently be used for prescribing Inspiratory Muscle Training.
¿Es la fuerza de prensión manual un buen indicador de condición física y composición corporal en pacientes con cáncer de mama que han terminado los tratamientos centrales de la enfermedad? Estudio EFICAN
Authors: Esteban-Simón Alba , Díez-Fernández David M , Alcaraz-García Celia , García-Martínez María del Mar , Moreno-Poza Nuria , Maldonado-Quesada Mercedes , Carrera-Ruiz Álvaro , Toro-de-Federico Antonio , Hachem-Salas Nur , Moreno-Martos Herminia , Vazquez-Sousa Rosa , Casimiro-Artés Miguel Á , Artés-Rodríguez Eva , Rodríguez-Pérez Manuel A , Casimiro-Andújar Antonio J , Soriano-Maldonado Alberto 
Published: September 2021

Objetivo: Evaluar la asociación entre la fuerza de prensión manual (FPM) y diversos parámetros de condición física y composición corporal en mujeres supervivientes de cáncer de mama.
Método: Se realizó un estudio transversal con los datos basales del ensayo clínico EFICAN (Ejercicio FÍsico para supervivientes de CÁNcer de mama). Participaron 60 mujeres supervivientes de cáncer de mama que habían terminado los tratamientos centrales de la enfermedad en los 10 años previos al comienzo del estudio, que no presentaban enfermedad pulmonar o cardiovascular, cáncer de mama metastásico, ni tenían prevista una intervención para reconstrucción mamaria en un plazo de 3 meses desde el comienzo del estudio. Se evaluó la fuerza de prensión manual mediante dinamometría manual, la fuerza muscular isométrica pico mediante dinamometría electromecánica funcional, el fitness cardiorrespiratorio (VO2máx) se estimó a través del Siconolfi step test, la amplitud de movimiento (ADM) en flexión de hombro mediante goniometría digital, y la composición corporal mediante bioimpedancia.
Resultados: Se observó una asociación positiva de la FPM con la masa muscular (r=0.423), y con la fuerza isométrica de miembro superior (r=0.523) e inferior (r=0.335), y una asociación negativa de la FPM con el porcentaje de grasa corporal (r=-0.405). Sin embargo, no se encontró asociación entre FPM y VO2máx ni ADM del hombro (P>0.05).
Conclusiones: Estos resultados sugieren que la FPM puede ser un buen indicador de fuerza muscular, así como de composición corporal en mujeres supervivientes de cáncer de mama. Futuros estudios prospectivos deberán evaluar el valor predictivo de la FPM en esta población.