bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chip-to-Chip High-Dimensional Teleportation via A Quantum Autoencoder
Authors: Zhang Hui , Wan Lingxiao , Haug Tobias , Mok Wai-Keong , Cai Hong , Shi Yuzhi , Chin Lip Ket , Karim Muhammad , Xiao Limin , Lo Guoqiang , Luo Xianshu , Gao Feng , Dong Bing , Assad Syed , Kim Myungshik , Kwek Leong Chuan , Liu Ai Qun 
Published: August 2021

Abstract
Quantum teleportation transfers unknown quantum states from one node in a quantum network to another. It is one of the crucial architectures in quantum information processing. The teleportation of high-dimensional quantum states remains challenging due to the difficulties in executing high-dimensional Bell state measurement. Here, we propose a Quantum Autoencoder-Facilitated Teleportation (QAFT) protocol for high-dimensional quantum teleportation, and report the first demonstration of QAFT on qutrits using an integrated photonic platform for future scalability. The key strategy is to reduce the dimension of the input states by erasing redundant information and reconstruct its initial state after chip-to-chip teleportation. Machine learning is applied in training the autoencoder to facilitate the teleportation of any state from a particular high-dimensional subspace and achieve the reconstruction of the unknown state (by the decoder) with high fidelities (~ 0.971). Experimentally, we teleport unknown qutrits by generating, transferring and manipulating photons, and training quantum autoencoders on a silicon chip. A teleportation fidelity of ~ 0.894 is demonstrated. Our scheme opens pathway towards quantum internet and cryptography to transfer unmeasured states in a quantum computer. It also lays the groundwork for machine learning technologies in quantum networks and quantum computations.
Expanded Noninvasive Prenatal Testing for Chromosomal aneuploidies and Copy Number Variants in a Cohort of 16128 Single Pregnancies
Authors: He Jing , Feng Xuan , Wang Xing , Zhang Qinghua , Zheng Lei , Lin Pengwu , Hao Shengju 
Published: August 2021

Abstract
Background: Noninvasive prenatal testing (NIPT) is based on second-generation genomic sequencing technology to scan cell-free fetal DNA originating from the placenta in maternal plasma. As the depth of sequencing increases, it can be used to focus on chromosomal aneuploidies, copy number variants (CNVs), and monogenic diseases. It can significantly improve the accuracy of prenatal screening and reduces the number of invasive testing.Methods: In this study, we retrospectively analyzed 16128 naturally conceived singleton pregnancies who underwent expanded NIPT to calculate the true positive rate (TPR) of chromosomal aneuploidies and CNVs, and analyzed the potential influence of maternal sex chromosome abnormalities (SCAs) and maternal CNVs on expanded NIPT results.Results: After invasive prenatal diagnosis and follow-up, 103 pregnancies were found to be true-positive, including 73 cases of chromosomal abnormalities and 30 cases of CNVs. The TPR of T21 was 84.62%, T18 was 50.00%, T13 was 22.22%, SCA was 34.06%, and CNVs was 40.28%. In addition, we found that the positive rate of aneuploidies increased with maternal age and that maternal SCAs accounted for 13.33% of the 60 false positive cases of SCAs.Conclusion: Expanded NIPT showed high sensitivity and specificity in detecting diseases of chromosomal abnormalities. It also shows good performance in detecting CNVs, but maternal SCAs and CNVs confused some NIPT results, indicating it is still necessary to study the potential maternal influence on expanded NIPT results and to report related clinical validation studies.
Anti-hyperglyceamic Effects of Psidium guajava LINN Crude Leaf Extracts and Fractions in Alloxan- induced Diabetic Mice.
Authors: Nwabunwanne Eze Uchenna , Anayaochukwu Eze Anthonius , Victor Ugwu Chukwuebuka , Maxwell Onuoha , Mary Ubenyi Stanley 
Published: August 2021

Abstract
In Nigeria, rural inhabitants often resort to herbal remedies and dietary control for the treatment and management of various forms of diabetes mellitus. This study was conducted to provide the rationale for the use of Psidium guajava leaves as a potent traditional antidiabetic remedy. The crude leaf extracts of n-hexane, methanol, and ethyl acetate of Psidium guajava were separately prepared by cold maceration. Then, the ethyl acetate crude extract of Psidium guajava leaves was fractionated by column chromatography to yield ethyl acetate bulked fractions: EF-I (1-75), EF-II (76-150), and EF- III (151-250). The n-hexane, ethyl acetate, and methanol crude leaf extracts and ethyl acetate bulked fractions (EF-I, EF-II, and EF-III) were evaluated for antidiabetic activity in alloxan-induced diabetic mice. The blood sugar levels of treated and untreated alloxan-induced diabetic mice were assayed as indices of antidiabetic effect. The phytochemical constituents of both crude extracts and ethyl acetate fractions of Psidium guajava leaves and the mean lethal dose (LD50) of ethyl acetate crude leaf extract of Psidium guajava were determined. The mean lethal dose (LD50) of ethyl acetate crude leaf extract was calculated to be 1500mg/kg b.w. The results indicated that oral administration of ethyl acetate, n-hexane, methanol crude extract, and ethyl acetate bulked fractions of Psidium guajava leaves at a dose of 100mg/kg b.w on treated groups exhibited much significant[p<0.001, p<0.01and p<0.05]anti- hyperglyceamic effect by ameliorating high blood sugar levels of alloxan-induced diabetic treated mice, while EF-II and EF-III showed non-significant[p>0.05] anti-hyperglyceamic activity for the reduction in blood sugar levels compared with the negative and positive control groups. The anti- diabetic potency of the crude leaf extracts and ethyl acetate fractions were in the order; EC>HC>MC>EF-I>EF-II>EF-III. The results of phytochemical screening of the crude extracts and ethyl acetate bulked fractions showed the presence of tannins, flavonoids, saponins, alkaloids, terpenoids, glycosides, and steroids while reducing sugar was absent. The results from this study give credence to the use of Psidium guajava as an antidiabetic agent in the management of diabetes mellitus.
Cementless Primary or Revision Stem in the First-time Revision Hip Arthroplasty for Aseptic Stem Loosening? A Retrospective Comparative Study.
Authors: Pai Fu-Yuan , Chou Te-Feng Arthur , Ma Hsuan-Hsiao , Chang Wei-Lin , Tsai Shang-Wen , Chen Cheng-Fong , Wu Po-Kuei , Chen Wei-Ming 
Published: August 2021

Abstract
IntroductionThe use of primary or revision stem during the first-time revision total hip arthroplasty(THA) procedure for aseptic stem loosening remains controversial. The aim of this study was to compare the outcome of patients that underwent revision THA with a primary or revision stem.Materials and MethodsWe retrospectively reviewed 78 patients that received first-time revision THA for aseptic stem loosening using primary(N=28) or revision stems(N=50). The bone defects were classified as Paprosky type I or II. The mean follow-up duration was 72.3±34.7 months. The primary outcome domains included surgical complications and implant failures. The secondary outcome domains included medical complications, 30-day and 90-day readmission, and Harris hip score (HHS).ResultsThe use of revision stem was associated with higher incidence of patient having complications (60.0% vs. 32.1%, p=0.018), including intraoperative femur fracture (28.0% vs. 7.1%, p=0.029) and greater trochanter fracture (16.0% vs. 0%, p=0.045), compared with the use of primary stem. The implant survival was comparable in both groups. HHS at the final follow-up was similar.ConclusionWith a lower risk of surgical complication and similar mid-term implant survival, cementless primary stem might be a better alternative to revision stem in the first-time revision THA for aseptic stem loosening.
Probing the Lubrication of Shear-Induced Self-Assembled Layer on Amorphous Carbon Films in Methane Atmosphere
Authors: Chen Lin , Wu Jian , Lu Zhibin , Shang Lunlin , Zhang Guangan , Xue Qunji 
Published: August 2021

Abstract
Demand for reduction in friction and improvement in wear resistance of moving parts propels exploration in frictional origin for amorphous carbon (a-C) film lubricating properties based on the interfacial states. Methane, as an ideal energy carrier and industrial raw material, is one of active gas. Consequently, the relations between the tribological behaviors of a-C film under methane atmosphere and load or interfacial states were discussed based on experimental and theoretical methods. Experimental results illustrated that, as the load increased, tribological system exhibited various interfacial shear strength at a load of zero and pressure dependence of the shear strength for tribological systems. And then the origin was revealed with theoretical calculation and resulted from the distributions of adsorbates across the sliding interface.
Cerebral Small Vessel Disease Phenotype and 5-year Mortality in Asymptomatic Middle-to-old Aged Individuals
Authors: Lee Wei-Ju , Chou Kun-Hsien , Lee Pei-Lin , Peng Li-Ning , Wang Pei-Ning , Lin Ching-Po , Chen Liang-Kung , Chung Chih-Ping 
Published: August 2021

Abstract
The present study aimed to determine whether a recently proposed cerebral small vessel disease (CSVD) classification scheme could differentiate the 5-year all-cause mortality in middle-to-old aged asymptomatic CSVD. Stroke-free and non-demented participants recruited from the community-based I-Lan Longitudinal Aging Study underwent baseline brain magnetic resonance imaging (MRI) between 2011 and 2014 and were followed-up between 2018 and 2019. The study population was classified into control (non-CSVD) and CSVD type 1–4 groups based on MRI markers. We determined the association with mortality using Cox regression models, adjusting for the age, sex, and vascular risk factors. A total of 735 participants were included. During a mean follow-up of 5.7 years, 62 (8.4%) died. There were 335 CSVD type 1 (57.9 ± 5.9 years), 249 type 2 (65.6 ± 8.1 years), 52 type 3 (67.8 ± 9.2 years), and 38 type 4 (64.3 ± 9.0 years). Among the four CSVD types, CSVD type 4 individuals had significantly higher all-cause mortality (adjusted hazard ratio = 3.7, 95% confidence interval = 1.3−10.8) compared to controls. This novel MRI-based CSVD classification scheme was able to identify individuals at risk of mortality at an asymptomatic, early stage of disease and might be applied for future community-based health research and policy.
Extension of the KDO Turbulence/Transition Model to Account for Roughness
Authors: FANG Chunfei , Xu Jinglei 
Published: August 2021

Abstract
Wall roughness significantly influences both laminar-turbulent transition process and fully developed turbulence. This work has developed a wall roughness extension for the KDO turbulence/transition model. The roughness effect is introduced via the modification of the k and νt boundary conditions, i.e., the wall is considered to be raised at an extra height. The equivalent roughness height is linked to the actual roughness height, and the ratio between them is determined by reasoning. With such a roughness extension, the predictions of the KDO RANS model agree well with the measurements of turbulent boundary layer with a sand grain surface, while the KDO transition model yields accurate cross-flow transition predictions of flow past a 6:1 spheroid.
Metadherin (MTDH) Overexpression Significantly Correlates with Advanced Tumor Grade and Stages among Colorectal Cancer Patients
Authors: Sultan Aimen , Sahar Namood-e , Riaz Syeda Kiran , Qadir Javeria , Waqar Shahzad Hussain , Haq Farhan , Khaliq Tanwir , Malik Muhammad Faraz Arshad 
Published: August 2021

Abstract
BackgroundColorectal cancer is the 4th leading cause of cancer related deaths affecting both men and women worldwide. In the present study, any probable role of MTDH mRNA expression in CRC tumorigenesis was explored using both discovery and validation cohorts. Methods and resultsAfter prior ethical and biosafety approvals, tumor tissue samples along with their adjacent controls were collected for this study from Pakistani patients diagnosed with colorectal cancer. RNA was isolated using Trizol reagent, followed by cDNA synthesis. Transcript analysis of MTDH was performed by using qPCR. Moreover, genome-wide expression of MTDH was also determined through micro-array data analysis using BRB- Array Tools software. MTDH expression was significantly high in tumor tissue samples (p<0.05) compared to their respective controls. Likewise, results of microarray analysis also revealed overamplification of MTDH in tumor samples as compared to controls. Expression of MTDH was also found to be positively correlated with KI-67 index (p<0.05) and were observed to be significantly upregulated in advance tumor grade (p< 0.05) and stage (p< 0.05). However, no association of MTDH overexpression with age and gender could be established. ConclusionHence, it can be concluded that MTDH is a core element that plays a pivotal role in colorectal tumorigenesis irrespective of patient’s age and gender. Molecular insight into the tumor microenvironment revealed MTDH as a niche, representing distinctive framework for cancer progression, thus, making it an innovative target strategy for colorectal cancer treatment.
Impact of targeted bundles to reduce the nebulization time gap from prescription to administration among red triaged patients in emergency department: An quality improvement initiative
Authors: sachdeva Seema Sachdeva seema , Kumar Akshay Kumar Akshay , Aggarwal Parveen Aggarwal Parveen 
Published: August 2021

Abstract
BackgroundSevere exacerbation of asthma are potentially life-threatening and therefore require prompt care and frequent management. Important elements of early treatment includes recognition of early signs and symptoms of breathing difficulty and timely prescription and administration of therapeutic agents. A subsequent delay in receiving nebulization during an acute exacerbation of asthma can leads to cardiac arrest and even death. AimTo reduce the gap in administration of nebulization from its prescription time among red triaged patients by 50% from its baseline. Setting and designThis interventional study was conducted among red triaged patients in emergency department of tertiary care hospital, India . Material and MethodsBaseline information was collected during first 4 weeks to find gap in administration of nebulization from its prescription time. Fish bone analysis and process map were laid down to analyse the situation. The intervention using targeted bundles was done via 3 PDSA (PDSA1: indenting the nebulizers, PDSA 2: training of doctors and nurses, PDSA 3; introducing equipment checklist) to reduce the gap . A run chart using time series analysis model was used to compare the pre and post intervention nebulization gap. ResultsTotal 74 patients (30 in pre- intervention, 44 in post intervention) admitted in red triaged area were observed for nebulization gap from prescription to administration. Median time for nebulization gap before intervention was 46.5 minutes which reduced to 15 minutes in post intervention phase. ConclusionThis bundles of targeted interventions was successful to reduce the nebulization gap. Key words: nebulization gap, prescription time, administration time
Phase I Trial of a Multi-Peptide COVID-19 Vaccine for the Induction of SARS-CoV-2 T-Cell Immunity
Authors: Walz Juliane , Heitmann Jonas , Bilich Tatjana , Tandler Claudia , Nelde Annika , Maringer Yacine , Marconato Maddalena , Reusch Julia , Jäger Simon , Denk Monika , Richter Marion , Anton Leonard , Weber Lisa , Roerden Malte , Bauer Jens , Rieth Jonas , Wacker Marcel , Hörber Sebastian , Peter Andreas , Meisner Christoph , Fischer Imma , Löffler Markus , Klein Reinhild , Rammensee Hans-Georg , Salih Helmut 
Published: August 2021

Abstract
T-cell immunity is central for the control of viral infections. CoVac-1 is a peptide-based vaccine candidate, composed of SARS-CoV-2 T-cell epitopes derived from various viral proteins, combined with the toll-like receptor 1/2 agonist XS15 emulsified in MontanideTM ISA51 VG, aiming to induce superior SARS-CoV-2 T-cell immunity to combat COVID-19. We conducted a Phase I open-label trial, including 36 participants aged 18 to 80 years, who received one single subcutaneous CoVAC-1 vaccination. The primary endpoint was safety analyzed until day 56. Immunogenicity in terms of CoVac-1-induced T-cell response was analyzed as main secondary endpoint until day 28. No serious adverse events and no grade 4 adverse events were observed. Expected local granuloma formation was observed in all study subjects, while systemic reactogenicity was absent or mild. SARS-CoV-2-specific T-cell responses targeting multiple vaccine peptides were induced in all study participants, mediated by multifunctional T-helper 1 CD4+ and CD8+ T cells. CoVac-1-induced interferon-γ T-cell responses by far surpassed those detected in COVID-19 convalescents and were unaffected by current SARS-CoV-2 variants of concern (VOC). Together, CoVac-1 showed a favorable safety profile and induced broad, potent, and VOC-independent T-cell responses, supporting the presently ongoing evaluation in a Phase II trial for patients with B-cell/antibody deficiency.

Funded by the Ministry of Science, Research and the Arts Baden-Württemberg, Germany; ClinicalTrials.gov number, NCT04546841.
Clinical Features of Excyclotorsion In The Non-Paretic Eye of Patients With Congenital Unilateral Superior Oblique Palsy
Authors: Cha Eun-Hyang , Ha Suk-Gyu , Suh Youngwoo , Kim Seung-Hyun 
Published: August 2021

Abstract
To investigate preoperative clinical features and postoperative results according to the correspondence between excyclotorsion and the paretic eye in patients with congenital unilateral superior oblique palsy (USOP). A retrospective review of medical charts was performed. The patients were divided into the accordance (preoperative fundus ocular excyclotorsion in the paretic eye) and discordance (preoperative ocular excyclotorsion in the non-paretic eye) groups. The degree of excyclotorsion (scale, 0–4) was measured. Age, sex, hypertropia at the primary position, fixation preference, inferior oblique overaction, and degree of excyclotorsion were measured at each visit. Ninety-eight patients were included in this study. There were 70 (71.4%) and 28 patients (28.6%) in the accordance and discordance groups, respectively. The mean age in the accordance and discordance groups was 9.2 ± 12.7 and 7.5 ± 8.9 years, respectively. Sixteen patients (22.9%) in the accordance group and 12 patients (42.9%) in the discordance group were aged under 2 years (p=0.04). A fixation preference for the paretic eye was observed in two (2.9%) and eight (28.6%) patients in the accordance and discordance groups, respectively (p < 0.01). The accordance group (2.3 ± 0.67) demonstrated a significantly higher degree of excyclotorsion than the discordance group (1.9 ± 0.64) (p = 0.03). The postoperative degree of excyclotorsion in the accordance group (0.14 ± 0.39) was lower than that in the discordance group (0.28 ± 0.71) (p = 0.01). The prevalence of residual postoperative excyclotorsion (>1) in the discordance group was significantly higher (14 patients, 50%) than that in the accordance group (16 patients, 22.9%) (p = 0.01).Twenty-eight percent of the patients with congenital USOP demonstrated excyclotorsion in the non-paretic eye. Preoperative discordance between excyclotorsion and the paretic eye was observed in patients who were under 2 years of age and preferred fixation of the paretic eye. The postoperative degree of excyclotorsion was significantly lower in the accordance group.
Comparison of Prospective and Retrospective Gated 4D Flow Cardiac MR Image Acquisitions in the Carotid Bifurcation
Authors: Hurd Elliott R. , Han Mengjiao , Mendes Jason K. , Hadley J. Rock , Johnson Chris R. , DiBella Edward V.R. , Oshinski John N. , Timmins Lucas 
Published: August 2021

Abstract
The superior temporal coverage of retrospective versus prospective gating in 4D flow cardiac MRI (cMRI) imaging offers advantages in comprehensively evaluating the hemodynamic environment across the complete cardiac cycle; however, retrospective acquisitions may result in temporal smoothing. Thus, the purpose of this study was to evaluate the agreement of 4D flow cMRI-derived bulk flow features and fluid (blood) velocities in the carotid bifurcation using prospective and retrospective gating techniques. Prospective and retrospective ECG-gated three-dimensional (3D) cine phase-contrast cardiac MRI with three-direction velocity encoding (i.e., 4D flow cMRI) data were acquired in ten carotid bifurcations from men (n = 3) and women (n = 2) that were cardiovascular disease-free. Velocity magnitude data were extracted from the fluid domain within the image volumes and evaluated across the entire volume or at defined anatomic planes (common, internal, external carotid arteries). Vector magnitudes were decomposed into components to quantify flow direction and disturbances, including retrograde flow. Flow streamlines encoded for velocity magnitude and velocity profiles were generated. Qualitative and quantitative agreement was observed in bulk flow features and fluid velocity magnitudes derived from either prospective or retrospective ECG-gated 4D flow cMRI. No significant differences in velocity magnitudes or components (υr, υθ, υz) were observed. Importantly, retrospective acquisitions captured increased retrograde flow in the internal carotid artery (i.e., carotid sinus) compared to prospective acquisitions. Prospective and retrospective ECG-gated 4D flow cMRI acquisitions provide comparable evaluations of the hemodynamic environment in the carotid bifurcation. However, the increased temporal coverage of retrospective acquisitions depicts disturbed blood flow patterns not captured by the prospective gating technique.
Autotelic Immersion - Interdependence of the Experience and Autotelic Engagement
Authors: Mikicin Mirosław 
Published: August 2021

Abstract
The aim of this study is to explore the relationships between experienced immersion and autotelic engagement in computer gamers. As the tendency to act for the sake of acting or not, autotelic v/s exotelic engagement makes the gamer more or less susceptible to experiencing immersion. The interdependence of experiencing immersion and the sense of autotelic engagement corresponds to the level of autotelic immersion. Students from different university majors (N=87) participated in the study. They completed 2 questionnaires: The Immersiveness Inventory (ING) and the Engagement Questionnaire (FLOW). The results of this study indicate that the experience of autotelic immersion is enhanced by autotelic engagement, manifesting autotelic cognitive properties during computer game playing. In such cases, Interaction with the environment, Sensory Engagement, Sense of Control, balance between ability level and challenge, intrinsic rewarding, concentrating and focusing, control, feedback, and action awareness merging intertwine with each other. Strong positive correlations of interaction with the virtual environment and sense of control were observed with all dimensions of autotelic engagement: the balance between ability level and challenge, loss of the feeling of self-consciousness, clear goals, intrinsic rewarding, concentrating and focusing, control, and autotelic experience. There is a strong directly proportional relationship between autotelicity and immersion.