bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated approach with UHPLC-Q-Exactive-tandem mass spectrometry, network analysis, and molecular docking to determine potential active compounds and mechanisms of Rhizoma Musae decoction in osteoarthritis treatment
Authors: Zhang Jian , Shen Wanyan , Liu Fanzhi , He Hehe , Han Shuquan , Luo Lina 
Published: January 2025

ObjectiveThis study aimed to identify the potential active compounds in Rhizoma Musae decoction and understand their mechanisms of action in osteoarthritis treatment.MethodsUHPLC-Q-Exactive-MS/MS technology was used for an in-depth analysis of the chemical compounds present in Rhizoma Musae decoction. A network analysis approach was used to construct a comprehensive network of compounds, targets, and pathways, which provided insights into the molecular mechanisms of Rhizoma Musae decoction in osteoarthritis treatment.ResultsThe integrated analysis revealed the presence of 534 chemical compounds in Rhizoma Musae decoction, with 7beta-hydroxyrutaecarpine, 7,8-dihydroxycoumarin, pinocembrin diacetate, and scopoletin being identified as potential active compounds. Potential targets such as GAPDH, AKT1, TNF, IL6, and SRC were implicated in key pathways including MAPK signaling pathway, lipid and atherosclerosis, PI3K-Akt signaling pathway, and IL-17 signaling pathway. Molecular docking studies showed significant binding affinity between the core targets and key components. In vitro cell experiments have demonstrated that RM decoction can enhance cell proliferation and upregulates the expression of TNFα, IL-6, and SRC, while down-regulating the expression of GAPDH and AKT1.ConclusionThe potential active compounds present in Rhizoma Musae decoction influence specific targets and signaling pathways involved in osteoarthritis pathogenesis, providing new insights for the functional development and utilization of RM.
Exploring the Mechanism of Clostridium autoethanogenum Protein for Broiler Growth Based on Gut Microbiota and Serum Metabolomics
Authors: Shan Chunqiao , Liu Yan , Liu Sisi , Li Chuang , Ma Chaoxin , Yu Hongmin , Li Juan , Jiang Guotuo , Tian Jing 
Published: January 2025

Intestinal health is vital for poultry production, and protein plays a key role in intestinal nutrition. The present study used 16S rRNA gene sequencing and serum metabolomics to investigate the effect of CAP on the cecal microflora structure and serum metabolites in 42-day-old broiler chickens. A total of 480 one-day-old Arbor Acres broiler chickens were randomly divided into four treatments with twelve replicates comprising 10 chickens each, evenly divided by sex. The four groups were basal diet group (CAP0), treatment group 1 (CAP2), treatment group 2 (CAP3), and treatment group 3 (CAP4). The broilers in the CAP0 group were fed a basal diet (without CAP), while those in the CAP2, CAP3, and CAP4 groups received diets containing 2%, 3%, and 4% CAP, respectively. Growth performance results showed that dietary CAP supplementation significantly ameliorated the feed conversion rate (FCR) of broilers at 42 days in the CAP3 and CAP4 groups (p < 0.05). Microbial results revealed that CAP did not alter the dominant microorganisms in the cecum at the phylum, family, and genus levels. LEfSe analysis showed significantly higher relative abundances of p_Desulfobacterota, f_Desulfovibrionaceae, and g_Ruminococcus in the CAP3 group compared to the CAP0 and CAP4 groups. Metabolomic analyses indicated that the effect of incorporating CAP into the diet on serum metabolites primarily focused on organic acids and their derivatives, small peptides, amino acid derivatives, and oxidized lipids. The addition of 3% or 4% CAP to the diet can enhance metabolic pathways such as the citrate cycle (TCA cycle) and arginine and proline metabolism. In summary, incorporating CAP into the diet can increase the relative abundance of beneficial bacteria in the cecum and improve the feed conversion efficiency of broilers by enhancing amino acid and energy metabolism.
Unveiling the Potency of Gardenia Extract Against H. pylori: Insights from In Vitro and In Vivo Studies
Authors: Werawatganone Pornpen , Werawatganon Duangporn , Noonak Nattida , Chayanupatkul Maneerat , Chatsuwan Tanittha , Klaikeaw Naruemon , Muangsiri Walaisiri , Siriviriyakul Prasong 
Published: January 2025

Background and aim: Gardenia jasminoides (G. jasminoides) could treat various inflammatory diseases. This study aimed to investigate the effects of G. jasminoides fruit extract on gastric inflammation and protective mechanisms in Helicobacter pylori (H. pylori)-induced gastritis. Experimental procedure: G. jasminoides fruit extract was prepared and analyzed for geniposide content. The inhibitory effect of the extract on H. pylori growth was investigated using the disk diffusion method. The in vitro anti-inflammatory property of the extract was evaluated using the erythrocyte membrane stabilization method. Thirty-five male Sprague–Dawley rats were inoculated with H. pylori (108–1010 colony-forming unit/mL) and divided into five groups. Each group was treated with various doses of the extract (98–395 mg/kg). The serum and stomach tissue of the rats were evaluated using enzyme-linked immunosorbent assay, histopathology, and immunohistochemistry. Results and conclusions: The geniposide content in the dried extract was 8.12% ± 0.79% by dry weight. The inhibition zone was observed at the extract ≥ 1.97 mg/disk, and the extract presented anti-inflammatory potential. The H. pylori-inoculated rats had a significant increase in serum interleukin (IL)-17, IL-33, and gastric epidermal growth factor (EGF) levels and a significant decrease in serum prostaglandin E2 level (p < 0.05) in conjunction with the development of gastric inflammation on histopathology. The treatment of the extract could significantly decrease the serum IL-17, IL-33, and gastric EGF levels, significantly increase the serum PGE2 level (p < 0.05), and improve gastric histopathology. Thus, G. jasminoides fruit extract attenuated H. pylori-induced gastritis by inhibiting bacterial growth, reducing inflammation, and enhancing protective mechanisms.
Development of Starter Cultures for Precision Fermentation of Kombucha with Enriched Gamma-Aminobutyric Acid (GABA) Content
Authors: Kim Geun-Hyung , Baek Kwang-Rim , Lee Ga-Eun , Lee Ji-Hyun , Moon Ji-Hyun , Seo Seung-Oh 
Published: January 2025

Kombucha, a fermented tea beverage, is produced through the symbiotic interaction of several microbial strains, including acetic acid bacteria, lactic acid bacteria, and yeast, collectively known as symbiotic culture of bacteria and yeast (SCOBY). As its health benefits and distinctive flavor gain wider recognition, consumer demand and research on kombucha fermentation have increased. This study focused on developing starter cultures to produce functional kombucha through precision fermentation technology using selected microbial strains newly isolated from food sources. The isolated bacterial and yeast strains were evaluated and selected based on their fermentation characteristics. Notably, a lactic acid bacterial strain was chosen for its ability to overproduce the γ-amino butyric acid (GABA), a functional food component known to enhance cognitive function and reduce mental stress. To produce the GABA-fortified kombucha, selected single strains of Acetobacter pasteurianus, Lactiplantibacillus plantarum, and Saccharomyces cerevisiae were mixed and used as starter cultures. By optimizing the inoculation ratios and initial sugar concentration, a functional kombucha enriched with acetic acid, lactic acid, and GABA was successfully produced. The resulting kombucha demonstrated 2.2 mg/L of GABA production and 1.15 times higher antioxidant activity after the fermentation, highlighting its enhanced health-promoting properties.
Serendipity in Non-Profit Founding and the Healing Response of Two Servant-Leaders to Crises of Migration
Authors: Von Behren Michael T. 
Published: January 2025

This article explores the intersection of non-profit founding with elements of servant-leadership. Drawing upon current research in social entrepreneurship and non-profit founding, the article reflects on these in light of the stories of two selfless individuals, Varian Fry and Enrique Morones, whose lives of servanthood spawned the founding of two influential organizations: the Emergency Rescue Committee (ERC) and the Border Angels. While sharing the stories of these organizations, and of their founding, this article highlights issues of immigration offering a healing perspective through five themes of servant-leadership articulated by Robert K. Greenleaf revealed in the lives of these non-profit founders. Along the way, this article introduces concepts of global citizenship as an antidote to fears that stoke nationalistic and isolationist mindsets, which are mindsets both the ERC and the Border Angels sought to overcome.
Servant-Leadership: A Forgiveness-Based Approach to Medical Errors, Complications, and Bad Outcomes
Authors: Johnson Wade C. 
Published: January 2025

In the United States, medical errors, clinical complications and bad outcomes are often managed through a medical-legal system that seeks retributive justice, costing billions of dollars, and leaving patients and healthcare providers with deep emotional wounds and fractured relationships. In contrast, a forgiveness-based approach through Servant-leadership offers patients and medical providers a holistic and restorative justice that acknowledges shared suffering, addresses intrinsic needs, and rebuilds the sacred sense of community once shared between the two groups. This paper explores the benefits of a Servant-leadership forgiveness-based approach to medical errors, clinical complications, and bad outcomes, including its positive impact on patients, healthcare workers, and costs borne by society.
Servant-Leadership, Self-Reflection, and Self-Transcendence
Authors: Schmidt Ryan 
Published: January 2025

Whether it be income, gender, or race inequity, the gap between the haves and have-nots in the United States continues to increase, yet most people remain only concerned with themselves (Singh, 2012). Even without intention, injustice can fester. Following Robert Greenleaf’s (1977/2002) premise that caring for others is the foundation of a good society, servant-leadership provides a vision for doing the necessary inner work to achieve self-awareness before engaging with the outer work of the world. When individuals better understand the conditions governing their thoughts, feelings, and actions, the potential exists to achieve self-transcendence, re-orienting their lives outward in the pursuit of social justice. Balancing the responsibility within self-reflection and servant-leadership, society stands to benefit by placing social equity ahead of personal gain, increasing participation in the fight for social justice, and creating equitable opportunities for non-dominant group community members. Discovering a meaningful approach to becoming sensitive to the concerns of others is a critical challenge facing humanity, one that requires conceptualizing a distinct and transformational future, one that further researching the combination of servant-leadership, self-reflection, and self-transcendence can help illuminate.
An Exploration of Christian Practitioner’s Personal Spirituality and Use of Spirituality in Practice
Authors: Stewart Chris 
Published: January 2025

There is significant literature generally supporting the importance of social worker spirituality. While there is some research exploring the various characteristics of practitioner spirituality, there is little empirical evidence that adopts a multidimensional operationalization of social workers spirituality and their perceptions of the use of spirituality in professional practice. Further, there appears to also be a lack of research specifically focused on Christian social workers. This study explored the relationship of multidimensional practitioner spirituality and their perspectives on the use of spirituality in practice. Testing demonstrated a significant difference in spirituality between religiously non-affiliated and Christian social workers as well as differences in their perspective on the use of spirituality in practice. Implications for social work practice are discussed.
La formación dual, un enfoque desde sus partes interesadas: caso Universidad de Cuenca-Ecuador
Authors: Astudillo Silvana , Bravo Hernández Alejandra , Armijos Karen 
Published: January 2025

El objetivo de este estudio es analizar el perfil, las competencias, las necesidades y las funciones de tres grupos de interés directos de la formación dual: estudiantes, tutores docentes y tutores empresariales de la carrera de Administración de Empresas modalidad dual que oferta la Universidad de Cuenca, Ecuador. Se aplicó la prueba de Kruskal-Wallis para determinar si existen diferencias significativas en la percepción del grado de desarrollo de las competencias entre los grupos de interés objeto de estudio y un análisis descriptivo y bivariado para identificar las necesidades y las funciones. Los hallazgos evidencian diferencias en las competencias desarrolladas por los actores. Además, la principal necesidad percibida por los estudiantes consiste en que los tutores empresariales conozcan la modalidad dual y cómo deben guiarlos en su proceso de formación, del docente tutor es integrar y relacionar la teoría con los desafíos que enfrentan las organizaciones y del tutor empresarial conocer el contenido de la materia núcleo y la asignación de tareas durante la fase empresa. El estudio sugiere potenciar las habilidades blandas en los estudiantes para que se desenvuelvan de manera efectiva en el entorno empresarial, los docentes tutores deben integrar adecuadamente los conceptos teóricos con las situaciones reales del entorno laboral, los tutores empresariales deben ser capacitados en la formación dual y desde luego la Institución de Educación Superior (IES) debe establecer relaciones estrechas entre los actores de la institución educativa y la empresa
Aportes a la Transformación de la Extensión Universitaria en la Sociedad Digital.
Authors: Camilo Parrón Elena , Pardo Gómez María , Izquierdo Pardo José 
Published: January 2025

La extensión universitaria como proceso formativo de la educación superior permite el vínculo permanente entre la universidad y la sociedad, debe estar a tono con la era digital, signada por la omnipresencia de las Tecnologías de la Información y las Comunicaciones (TIC). No obstante, el aún limitado aprovechamiento por parte de los actores (intra/extra) universitarios de las posibilidades que estas ofrecen, lo que obstaculiza la dinámica de este proceso, provocando que no se alcancen los resultados esperados. Este trabajo tiene como objetivo mostrar la dinámica tecno-formativa extensionista, aportando un modelo y una estrategia, ambos de naturaleza pedagógica, los cuales se erigen como resultados teórico- metodológicos para al perfeccionamiento de este proceso, en correspondencia con las exigencias impuestas por esas tecnologías.
Application of Marine Algae for Bio-tanning System
Authors: Ragavendar Harish , Jayakumar GC , Sundar V. John , Selvi A. Tamil 
Published: January 2025

Sea weeds are plant-like organisms which are commonly grown in coastal regions. These materials are explored for different industrial applications such as food, cosmetics, chemicals, paint, pharmaceutical, etc. Several studies have been reported on the antimicrobial and antioxidant properties of various seaweed. However, utilization of seaweed for stabilization of collagen has been less explored. Recovery and reuse of collagen from tannery waste was found to be more prominent in the waste to wealth mission of the leather industry. Bio-crosslinkers from marine waste would be a new avenue for collagen stabilization. In the present research, phlorotannin, has been extracted and characterized for its tanning ability. Extracted phlorotannin was interacted with collagen at different hierarchical organizations (collagen solution, rat tail tendon and skin) to understand the interaction efficacy. Phlorotannin interacted collagen samples have been physico-chemically characterized through absorption and vibrational spectroscopic techniques. From these experimental studies, it has been found that extracted phlorotannin can act as a potential stabilizing agent, which enhances thermal resistance of the skin matrix. Phlorotannin substantially influences collagen aggregation, by enhancing the rate of aggregation without affecting the architectural ordering of collagen. This study implicates the waste utilization from coastal areas for stabilization of collagen, which is a by-product of meat industry.
Analisis Kondisi Fisik Trotoar Terhadap Tingkat Kenyamanan Pejalan Kaki
Authors: Indrajaya Indrajaya , Rusida Rusida , Kasim Ayub 
Published: January 2025

Tujuan dari penelitian ini adalah untuk mengetahui tingkat kenyamanan pejalan kaki pada trotoar Jalan Jenderal Sudirman Kota Palopo. Metode yang digunakan dalam penelitian ini adalah kuantitatif dengan mengumpulkan data observasi, dokumentasi dan studi pustaka, pengolahan data dilakukan menggunakan Sofwer SPSS Versi 20. Hasil penelitian menunjukkan uji regresi linier berganda varibel bebas diketahui mampu berpengaruh secara positif terhadap tingkat kenyamanan, dan hasil uji f variabel bebas berpengaruh secara signifikan terhadap variabel tingkat kenyamanan dengan nilai signifikansi sebesar 0,000 < 0.05 yang artinya variabel bebas secara simultan atau bersama-sama mampu berpengaruh signifikansi terhadap variabel tingkat kenyamanan
The aim of this research is to determine the level of pedestrian comfort on the sidewalks of Jalan Jenderal Sudirman, Palopo City. The method used in this research is quantitative by collecting observation data, documentation and literature study, data processing is carried out using SPSS Version 20 software. The results of the research show that the independent variable multiple linear regression test is known to be able to positively influence the level of comfort, and the results of the variable f test freedom has a significant effect on the comfort level variable with a significance value of 0.000 < 0.05, which means that the independent variables simultaneously or together are able to have a significant effect on the comfort level variable
Serbuk Kapur Hasil Pembakaran Kulit Kerang Sebagai Pengganti Agregat Halus untuk Bahan Konstruksi Ramah Lingkungan
Authors: Sudirman Sudirman 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh substitusi agregat halus dari serbuk cangkang kerang pada kuat tekan, dan daya serap air pada beton. Penelitian ini menggunakan metode kuantitatif melalui serangkaian eksperimen terhadap benda uji berupa kubus berukuran 15 cm3, dengan penambahan serbuk cangkang kerang pada variasi 10%, 20%, 30%, dan 50%. Hasil penelitian menunjukkan bahwa dengan penambahan 10% serbuk cangkang kerang, kuat tekan beton mengalami penurunan relatif sedikit menjadi 14.29 Mpa (dibandingkan dengan kuat tekan pada beton normal, yaitu 14.30 Mpa). Sedangkan dengan variasi penambahan 20%, 30%, dan 50% menunjukkan penurunan kuat tekan secara signifikan masing-masing menjadi 14.00 Mps, 11.48 Mpa, dan 10.44 Mpa. Berdasarkan hasil test, penambahan serbuk cangkang kerang dengan variasi 10%, 20%, 30%, dan 50%, daya serap air menunjukkan peningkatan masing-masing menjadi 0.52%, 0.981%, 1.088%, dan 0.832%.
This research aims to determine the effect of substitution of fine aggregates from shell powder on compressive strength, and water absorption in concrete. This research uses a quantitative method through a series of experiments on test specimens in the form of cubes size 15 cm3, with the addition of shell powder at variations of 10%, 20%, 30%, and 50%. Study result shows that with the addition of 10% shell powder, the compressive strength of concrete decreased slightly to 14.29 Mpa (compared to the compressive strength of normal concrete, 14.30 Mpa). Meanwhile, with additional variations of 20%, 30% and 50% show a significant decrease in compressive strength to 14.00 Mps, 11.48 Mpa and 10.44 Mpa respectively. Based on test results, the addition of shell powder with variations of 10%, 20%, 30% and 50%, water absorption showed improvements to 0.52%, 0.981%, 1.088% and 0.832% respectively.
TO THE QUESTION OF DEVELOPMENT METHODOLOGY FOR ASSESSMENT OF PRODUCTION RISKS IN MECHANICAL BUILDING
Authors: Tairova Tamara 
Published: January 2025

Goal. Develop the methodology for assessing production risks at workplaces of mechanical engineering workers.
Methodology. The methodology has been developed for assessing industrial risks during the operation of equipment, that can lead to dangerous situation with employee injury. Such a situation is characteristic of the complex argotic system, that is, the system whose constituent element is human operator. When developing the methodology for assessing industrial risk at the workplaces in mechanical engineering workers, the author was guided by the premise consistency that in order to prevent dangerous situations, it is necessary to have information as about industrial risks at the workplace for previous periods and for systematic violations of the requirements of labor protection legislation by both the employee and the employer.The developed methodology for assessing industrial risks at the workplace is based on the use of statistical data on injured persons at machine-building enterprises in previous years, where accidents occurred due to violations of the requirements of labor protection legislation by both the employee and the employer, as well as by the employee and the employer (simultaneously). When forming data on injured persons by year, methods of mathematical statistics using the theory of stochastic processes were used. For the quantitative assessment of industrial risks in mechanical engineering, the basic provisions of the theory of probabilities and statistical data on the causes of injuries to participants in the labor process for each of the 12 years of the study were used. The formation of statistical data for the assessment of production risk in mechanical engineering was carried out at the State University "NNDIPBOP» and based on the results of the analysis of each accident at the enterprises of the industry. Scientific novelty. For the first time, the methodology of industrial risk was developed for assessing production risks, the occurrence of which is associated with the unsatisfactory state of production equipment and non-compliance by the participants of the labor process with the requirements of the legislation on labor protection in mechanical engineering assessment in mechanical engineering. The methodology of industrial risk assessment in mechanical engineering is based on statistical data on injured persons, analysis of the condition of production equipment, the work of which resulted in injuries to workers, and the developed algorithm for the systematic analysis of statistical data.Practical value. The article proves that when forming data on injured people in mechanical engineering, it is advisable to rely on the developed methodology for assessing industrial risks. The obtained results from the assessment of industrial risks serve as the basis for substantiating indicators of economic motivation of both the employee and the employer to stimulate them to comply with the requirements of the labor protection legislation.