bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the SARS-COV-2 Outbreak on Epidemiology and Management of Major Trauma in France: Registry-Based Study. The COVITRAUMA Study
Authors: Moyer Jean-Denis , James Arthur , Gakuba Clément , Boutonnet Mathieu , Angles Emeline , Rozenberg Emmanuel , Bardon Jean , Clavier Thomas , Legros Vincent , Werner Marie , Mathais Quentin , Ramonda Veronique , Berthelot Yann , Colas Clelia , Minh Pierre Le , Pottecher Julien , Gauss Tobias 
Published: January 2021

Abstract
BackgroundEvidence increases to suggest that the reallocation of health care resources during considerable the COVID-19 pandemic impacts considerably any health system. This study describes the epidemiology and the outcome of major trauma patients admitted to centers in France during the first wave of the COVID-19 outbreak. MethodsThis retrospective observational study included all consecutive trauma patients aged 15 years and older admitted into 15 centers participating to the TraumaBase® registry in France during the first wave of the SARS-CoV-2 pandemic in France. ResultsOver a 4 years-study period, 5762 patients were admitted between the first week of February and mid-June. This cohort was split between patients admitted during the first 2020 pandemic wave in France (pandemic period, 1314 patients) and those admitted during the corresponding period in the three previous years (2017-2019, 4448 patients). Patient demographics changed substantially during the pandemic and more specifically during the lockdown period specially with a reduction in both absolute numbers admitted and the proportion of road traffic accidents (348 annually 2017-2019 [55.4 % of trauma admissions] vs 143 [36.8 %] in 2020 p<0.005). Mortality during the pandemic period and the difference between predicted and observed mortality was not different compared to the non-pandemic years. ConclusionsDuring this first wave of COVID-19 in France, management of trauma patients admitted to regional Traumacenters was not significantly altered, despite medical resources being reallocated and reorganized. Mortality as well as prehospital and in hospital care remained stable throughout the period of the first pandemic wave despite a massive increase in demand for acute care beds.
Anticancer Effects of Disulfiram: A Systematic Review of in Vitro, Animal, and Human Studies
Authors: wang ling , yu yang , zhou cong , wan run , Li Yumin 
Published: January 2021

Abstract
Background and objectives: Cancer morbidity and mortality rates remain high, and thus, at present, considerable efforts are focused on finding drugs with higher sensitivity against tumor cells and fewer side effects. Several preclinical and clinical studies have examined the potential of repurposing disulfiram (DSF) as an anticancer treatment. This systematic review aimed to assess evidence regarding the antineoplastic activity of DSF in in vitro and in vivo models, as well as in humans.Methods: Two authors independently conducted this systematic review of English and Chinese articles from the PubMed, Embase, and the Cochrane Library databases up to July 2019. Eligible in vitro studies needed to include assessments of the apoptosis rate by flow cytometry using annexin V/propidium iodide, and studies in animal models and clinical trials needed to examine tumor inhibition rates, and progression-free survival (PFS) and overall survival (OS), respectively. Data were analyzed using descriptive statistics.Results: Overall, 35 studies, i.e., 21 performed in vitro, 11 based on animal models, and three clinical trials, were finally included. In vitro and animal studies indicated that DSF was associated with enhanced apoptosis and tumor inhibition rates. Human studies showed that DSF prolongs PFS and OS. The greatest anti-tumor activity was observed when DSF was used as combination therapy or as a nanoparticle-encapsulated molecule.Conclusions: This systematic review provides evidence regarding the anti-tumor activity of DSF in vitro, in animals, and in humans and indicates the optimal forms of treatment to be evaluated in future research.
Kernel Weighted Least Square Approach for Imputing Missing Values of Metabolomics Data
Authors: Kumar Nishith , Hoque Md. , Sugimoto Masahiro 
Published: January 2021

Abstract
Mass spectrometry is a modern and sophisticated high-throughput analytical technique that enables large-scale metabolomics analyses. It yields a high dimensional large scale matrix (samples × metabolites) of quantified data that often contain missing cell in the data matrix as well as outliers which originate from several reasons, including technical and biological sources. Although, in the literature, several missing data imputation techniques can be found, however all the conventional existing techniques can only solve the missing value problems but not relieve the problems of outliers. Therefore, outliers in the dataset, deteriorate the accuracy of imputation. To overcome both the missing data imputation and outlier’s problem, here, we developed a new kernel weight function based missing data imputation technique (proposed) that resolves both the missing values and outliers. We evaluated the performance of the proposed method and other nine conventional missing imputation techniques using both artificially generated data and experimentally measured data analysis in both absence and presence of different rates of outliers. Performance based on both artificial data and real metabolomics data indicates that our proposed kernel weight based missing data imputation technique is a better performer than some existing alternatives. For user convenience, an R package of the proposed kernel weight based missing value imputation technique has been developed which is available at https://github.com/NishithPaul/tWLSA .
Allergen protease-induced Gsdmd p40 controls IL-33 secretion
Authors: Sun Bing , Wu Bin , Wu Dong , Shao Feng , Zhang Yaguang , Chen Wen , Yan Chenghua , Zhang Ronghua , Chen Shuangfeng , Chen Min , Zhong Shufen , Zhu Songling , Li Xuezhen , Lu Xiao , Zhang Danyan , Ling Zhiyang , Ma Liyan , Zhu Jinfang , Fan Weiguo 
Published: January 2021

Abstract
Interleukin (IL)-33, an epithelial cell-derived cytokine that responds rapidly to environmental insult, has a critical role in initiating airway inflammation, such as that in asthma. However, the molecular mechanism underlying IL-33 secretion following allergen exposure is not clear. Here, we demonstrated that Gasdermin D (Gsdmd) functions as a conduit for IL-33 secretion following allergen protease exposure. Gsdmd was rapidly cleaved into a functional neo-form, the N-terminal p40 fragment (p40 NT-Gsdmd), in the murine airway epithelium when cells were exposed to allergen proteases from fungi, house dust mites (HDMs), or bacteria. This cleavage event that produces the p40 Gsdmd fragment was independent of inflammatory caspases-1/11, as it could not be inhibited by caspase-1 and caspase-11 deficiency in murine cells. The functional p40 NT-Gsdmd fragment directly contributed to the secretion of both the nuclear full-length form and cytosolic mature form of IL-33. Both Gsdmd deficiency and blockade of the generation of p40 by amino acid mutation or deletion of residues 308–313 (ELRQQ) in the Gsdmd sequence could efficiently prevent IL-33 release in airway epithelial cells. In mice, Gsdmd deficiency prevented IL-33 release and hindered the activation of group 2 innate lymphoid cells (ILC2s), thus alleviating airway inflammation and lung tissue damage after stimulation with HDMs or papain. Our findings uncovered a mechanism of Gsdmd-mediated IL-33 release under allergen exposure and offer insight into Gsdmd cleavage prevention as a potential approach to reduce allergic airway inflammation.
An Insight into Patients’ Perspectives on their Participation in Medical Decision Making in Diabetes Mellitus Care in Malawi.
Authors: Makwero Martha , Muula Adamson , Anyanwu Felix , Igumbor Jude 
Published: January 2021

Abstract
Background: Patient participation in their own care has potential to improve experiences and responsiveness in chronic disease situations. Patient participation is a basic tenet for a patient centred care experience. However, the documented experiences show that patient participation in care decisions making is wanting. As Malawi strives to imbibe and institutionalise the concept of patient centred care, it is important to examine the experiences of patients regarding participation in their care as this may provide evidence to support policy implementation strategies on the same. Aim: The study therefore sought to describe DM patients’ experiences of participation in shared decision making in Malawi.Methods: This qualitative exploratory study involved patients attending DM clinics in four public health facilities in Southern Malawi. Using SHARE framework, we analysed data from 15 in-depth interviews and two focus group discussions. Results: From the perspective of DM patients, this study elucidated that participation in care was largely lacking in clinical encounters. Some of the prominent gaps identified in the interactional process of care included: i) unfavourable ambience for participation, ii) insufficient bidirectional informational exchange and iii) inconsideration for patients’ preferences and values, iv) paternalistic power tendencies and, v) lack of evaluation of decisions made. Conclusion: The study highlights gaps in the practice of patients’ participation in medical decisions. Patients’ reproof of paternalistic models of care confirms that transforming medical education through curriculum review for providers may be a good starting point. The review should focus on the content and effective delivery of competencies relating to provider roles and practices on patient participation.
Women’s Perception of Continuity of Team Midwifery Care in Iran: A Qualitative Study
Authors: shahinfar sholeh , abedi parvin , najafian mahin , abbaspoor zahra , Mohammadi Eesa , Alianmoghaddam narges 
Published: January 2021

Abstract
Background: Understanding the pregnant women’s perception of continuity of team midwifery care is necessary for introducing and implementing this model of midwife-led care in the Iranian maternity services. This qualitative study aims to explore women’s perception of continuity of team midwifery care in Iran. Methods: This research is a qualitative study conducted in Iran to explore women's perception of continuity of team midwifery care during pregnancy, birth and postpartum from October 2019 to August 2020. 15 semi-structured interviews were conducted with women individually through a purposive sampling method. Interviews were digitally recorded and transcribed verbatim and analyzed using conventional content analysis. Results: From the data analysis, two themes, four main categories, and nine subcategories emerged. The themes were “Maternal empowerment” and “Mother’s satisfaction during the transition from pregnancy to motherhood”. The first theme included two categories of improving self-efficacy during antenatal education classes and the effective midwife-mother interaction. The second theme composed of two categories of satisfaction with the process of pregnancy, childbirth and postpartum as well as satisfaction with motherhood.Conclusion: Findings of this qualitative study highlight the effectiveness of continuity of team midwifery model of care for promoting empowerment and satisfaction in women during pregnancy, birth and postpartum. The results of this study could pave the way for developing, introducing and implementing the midwife-led continuity models of care in Iran.
Early Plain Film After Volar Plate Fixation for Distal Radius Fractures: Is Reallly Useful?
Authors: Cheng Wenjing - , DING GUOZHENG - 
Published: January 2021

Abstract
Background: The value of early postoperative radiographs is generally questioned after volar plate fixation(VLP) for distal radius fractures(DRFs). The purpose of this study was to evaluate the utility of early routine radiographs following volar plate fixation.Methods:A restropective study was developed on distal radius fractures treated with volar plate fixation between 1 January 2016 and 1 January 2020 in our hospital. We obtain relevant information from patient electronic records including basic patient information and treatment information.Reoperation or further checking after early postoperative radiographs was defined as management change，which illustrates early postoperative radiographs influence postoperative treatment.Results: A total of 213 patients treated with VLP were included. There are 179 patients having early postoperative radiographs in included patients. Two out of 179 patients were altered management,which underwent further imaging with computed tomography(CT) due to pain and swelling.This two patients were in line with Type C(AO/OTA classification). No patient has surgery again.Conclunsion: Early postoperative radiographs can not bring about an adjustment in postoperative management with VLP after DRF.But intra-articular fractures may still benefit from early postoperative radiographs compared with extra-articular fractures.
Cross-Cultural Translation and Validation of the Spanish Version of the Patellofemoral Pain and Osteoarthritis Subscale of the KOOS (KOOS-PF)
Authors: Martinez-Cano Juan Pablo , Vernaza-Obando Daniel , Chica Julián , Castro Andrés Mauricio 
Published: January 2021

Abstract
Background: Patellofemoral pain is a very common complaint in orthopedic sports medicine clinics. Disease-specific patient-reported outcome measures (PROMs) are useful for research and clinical practice; thus, it is important to have validated translations available for new PROMs. This study aims to translate and validate the Spanish version of the patellofemoral pain and osteoarthritis subscale of the knee injury and osteoarthritis outcome score (KOOS-PF).Methods: The KOOS-PF was translated and culturally adapted to Spanish following current guidelines, which included translation, back-translation, conciliation and pilot studies. Patients with a diagnosis of patellofemoral pain and/or osteoarthritis from one medical center were invited to participate and complete the questionnaire. The evaluation of the score included internal consistency (Cronbach´s alpha), floor and ceiling effects, measurement error, minimal detectable change and minimal important change. For test-retest reliability, the intraclass correlation coefficient (ICC) was used, and for responsiveness, the global rating of change (GROC) scale was measured one month later.Results: Sixty patients with patellofemoral pain and/or osteoarthritis were included in the study. The Spanish version showed very good internal consistency (Cronbach’s alpha: 0.93) and test-retest reliability (intraclass correlation coefficient: 0.82). Responsiveness was confirmed, with the KOOS-PF demonstrating a strong correlation with the GROC score (r 0.64). The minimal detectable change was 11.1 points, the minimal important change was 17.2 points, and there were no floor or ceiling effects for the score.Conclusions: The Spanish version of the KOOS-PF demonstrated very good measurement properties, including internal consistency, reliability and responsiveness. The KOOS-PF can be used in Spanish-speaking patients for clinical and research purposes in patellofemoral pain and osteoarthritis.Trial registration: Fundación Valle del Lili, Biomedical Research Ethical Committee: No. 01438.
A modified chief complaint-based cardiac triage strategy for reducing delays in the management of patients with ST-elevation myocardial infarction
Authors: Su Hung-Yuan , Tsai Jen-Long , Hsu Yin-Chou , Lee Kuo-Hsin , Chang Chao-Sheng , Sun Cheuk-Kwan , Wang Yu-Han , Hsu Chih-Wei 
Published: January 2021

Abstract
Timely performing electrocardiography (ECG) is crucial for early detection of ST-elevation myocardial infarction (STEMI). For shortening door-to-ECG time, a chief complaint-based “cardiac triage” protocol comprising (1) raising alert among medical staff with bedside triage tags, and (2) immediate bedside ECG after focused history-taking was implemented at the emergency department (ED) in a single tertiary referral center. All patients diagnosed with STEMI visiting the ED between November 2017 and January 2020 were retrospectively reviewed to investigate the effectiveness of strategy before and after implantation. Analysis of a total of 117 ED patients with STEMI (pre-intervention group, n = 57; post-intervention group, n = 60) showed significant overall improvements in median door-to-ECG time from 5 to 4 minutes (p = 0.02), achievement rate of door-to-ECG time < 10 minutes from 45–57% (p = 0.01), median door-to-balloon time from 81 to 70 minutes (p < 0.01). Significant trends of increase in achievement rates for door-to-ECG and door-to-balloon times (p = 0.01 and p = 0.006, respectively) was noticed after strategy implementation. The incidence of door-to-ECG time > 10 minutes for those with initially underestimated disease severity was also reduced from 90–10% (p < 0.01). In conclusion, a chief complaint-based “cardiac triage” strategy successfully improved the quality of emergency care for STEMI patients through reducing delays in diagnosis and treatment.
The F2-Isoprostane:Thromboxane-prostanoid receptor signaling axis drives persistent fibroblast activation in pulmonary fibrosis
Authors: Suzuki Toshio , Kropski Jonathan , Chen Jingyuan , Carrier Erica , Chen Xinping , Sherrill Taylor , Polosukhin Vasily , Han Wei , Rathinasabapathy Anandharajan , Gutor Sergey , Gulleman Peter , Banovich Nicholas , Tanjore Harikrishna , Freeman Michael , Tada Yuji , Young Lisa , Gokey Jason , Blackwell Timothy , West James 
Published: January 2021

Abstract
While transient fibroblast activation is a normal and adaptive aspect of injury-repair in many contexts, persistent fibroblast activation is a hallmark of idiopathic pulmonary fibrosis (IPF) and other chronic fibrotic lung diseases. The mechanisms regulating persistent fibroblast activation in IPF have not been fully elucidated. In the lungs of IPF patients and in mice with experimental lung fibrosis, we observed that expression of the thromboxane-prostanoid receptor (TBXA2R) was increased in fibroblasts. Genetic deletion of TBXA2R, but not inhibition of thromboxane synthase, protected mice from bleomycin-induced lung fibrosis, suggesting an alternative ligand activates profibrotic TBXA2R signaling. We found that F2-isoprostanes (F2-IsoPs), nonezymatic products of arachidonic acid metabolism generated in the setting of reactive oxygen species (ROS), are persistently elevated in experimental lung fibrosis and act as an alternative TBXA2R ligand. Further studies demonstrated that F2-isoprostanes signal through TBXA2R to activate Smad signaling, revealing TBXA2R as a previously unrecognized regulator of the transforming growth factor beta (TGF-β) pathway. Further, treatment with the small-molecule TBXA2R antagonist ifetroban protected mice from lung fibrosis in three pre-clinical models: bleomycin treatment, Hermansky-Pudlak Syndrome, and radiation-induced fibrosis. Importantly, treatment with ifetroban during the fibrotic phase of bleomycin injury markedly enhanced fibrotic resolution. Together, these studies implicate TBXA2R signaling as a crucial mediator linking oxidative stress to fibroblast activation and indicate that TBXA2R antagonists could be efficacious for treatment of IPF and other chronic fibrotic disorders.
Physician Associate/Assistant Impacts on Cancer Diagnosis in Primary Care: A Systematic Review
Authors: Sheringham Jessica , Kassianos Angelos , Plackett Ruth , Khan Anwar , King Angela , Cornes Michelle 
Published: January 2021

Abstract
Background: Symptom recognition and timely referral in primary care are crucial for the early diagnosis of cancer. Physician assistants or associates (PAs) have been introduced in 15 healthcare systems across the world, with numbers increasing to address primary care physician shortages. Little is known about their impact on suspected cancer recognition and referral. This review sought to summarise findings from international observational studies on PAs’ competence and performance on processes concerned with the quality of recognition and referral of suspected cancer in primary care. Method: A rapid systematic review of international peer-reviewed literature was performed (PROSPERO reference: CRD42019154114). Searches were undertaken on OVID, EMBASE, Web of Science, and CINAHL databases (2009-2019). Studies were eligible if they reported on PA skills, processes and outcomes relevant to suspected cancer recognition and referral. Title and abstract screening was followed by full paper review and data extraction. synthesis of qualitative and quantitative findings was undertaken on three themes: deployment, competence, and performance. Preliminary findings were discussed with an expert advisory group to inform interpretation. Results: From 876 references, 15 eligible papers were identified, of which 13 were from the USA. Seven studies reported on general clinical processes in primary care that would support cancer diagnosis, most commonly ordering of diagnostic tests (n=6) and referrals to specialists (n=4). Fewer papers reported on consultation processes, such as examinations or history taking (n=3) Six papers considered PAs’ competence and performance on cancer screening. PAs performed similarly to primary care physicians on rates of diagnostic tests ordered, referrals and patient outcomes (satisfaction, malpractice, emergency visits). No studies reported on the timeliness of cancer diagnosis. Conclusion: This review of peer-reviewed literature combined with advisory group interpretation suggests the introduction of PAs into primary care may maintain the quality of referrals and diagnostic tests needed to support cancer diagnosis. It also highlights the lack of research on several aspects of PAs’ roles, including outcomes of the diagnostic process.
Three-Dimensional Electronic Microfliers With Designs Inspired by Wind-Dispersed Seeds
Authors: Rogers John , Kim Bong Hoon , Li Kan , Kim Jin-Tae , Park Yoonseok , Jang Hokyung , Wang Xueju , Xie Zhaoqian , Won Sang , Jang Woo Jin , Lee Kun Hyuk , Chung Ted , Jung Yei Hwan , Heo Seung Yun , Lee Yechan , Kim Juyun , Cai Tengfei , Kim Yeonha , Prasopsukh Poom , Yu YongJoon , Yu Xinge , Luan Haiwen , Song Honglie , Zhu Feng , Zhao Ying , Chen Lin , Han Seung Ho , Kim Jiwoong , Oh Soong Ju , Lee Heon , Lee Chi Hwan , Huang Yonggang , Chamorro Leonardo , Zhang Yihui 
Published: January 2021

Abstract
Large, distributed collections of miniaturized, wireless electronic devices may form the basis of future systems for environmental monitoring, population surveillance, disease management and other applications that demand coverage over expansive spatial scales. In this paper, we show that wind-dispersed seeds can serve as the bio-inspiration for unusual aerial schemes to distribute components for such networks via controlled, unpowered flight across natural environments or city settings. Techniques in mechanically guided assembly of three-dimensional (3D) mesostructures provide access to miniature, 3D fliers optimized for such purposes, in processes that align with the most sophisticated production techniques for electronic, optoelectronic, microfluidic and microelectromechanical technologies. We demonstrate a range of 3D macro-, meso- and microscale fliers produced in this manner, including those that incorporate active electronic payloads. Analytical, computational and experimental studies of the aerodynamics of high-performance structures of this type establish a set of fundamental considerations in bio-inspired design, with a focus on 3D fliers that exhibit controlled rotational kinematics and low terminal velocities. Battery-free, wireless devices for atmospheric measurements provide simple examples of a wide spectrum of applications of these unusual concepts.