bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic risk factors associated with gestational diabetes in a multi-ethnic population
Authors: Benny Paula , Ahn Hyeong Jun , Burlingame Janet , Lee Men-Jean , Miller Corrie , Chen John , Urschitz Johann 
Published: December 2021

AimsGenome-wide association studies have shown an increased risk of type-2-diabetes (T2DM) in patients who carry single nucleotide polymorphisms in several genes. We investigated whether the same gene loci confer a risk for gestational diabetes mellitus (GDM) in women from Hawaii, and in particular, Pacific Islander and Filipino populations.MethodsBlood was collected from 291 women with GDM and 734 matched non-diabetic controls (Pacific Islanders: 71 GDM, 197 non-diabetic controls; Filipinos: 162 GDM, 395 controls; Japanese: 58 GDM, 142 controls). Maternal DNA was used to genotype and show allele frequencies of 25 different SNPs mapped to 18 different loci.ResultsAfter adjusting for age, BMI, parity and gravidity by multivariable logistic regression, several SNPs showed significant associations with GDM and were ethnicity specific. In particular, SNPs rs1113132 (EXT2), rs1111875 (HHEX), rs2237892 (KCNQ1), rs2237895 (KCNQ1), rs10830963 (MTNR1B) and rs13266634 (SLC30A8) showed significant associations with GDM in Filipinos. For Japanese, SNPs rs4402960 (IGFBP2) and rs2237892 (KCNQ1) were significantly associated with GDM. For Pacific Islanders, SNPs rs10830963 (MTNR1B) and rs13266634 (SLC30A8) showed significant associations with GDM. Individually, none of the SNPs showed a consistent association with GDM across all three investigated ethnicities.ConclusionSeveral SNPs associated with T2DM are found to confer increased risk for GDM in a multiethnic cohort in Hawaii.
Prevalence of perceived stigma and associated factors among primary caregivers of children and adolescents with mental illness, Addis Ababa, Ethiopia: Cross-sectional study
Authors: Minichil Woredaw , Getinet Wondale , Kassew Tilahun 
Published: December 2021

BackgroundMental illness exposes persons to stigma and this stigma also affects family caregivers of persons with mental illness. The objective of the study was to assess the prevalence of perceived stigma and associated factors among primary caregivers of children and adolescents with mental illness, Addis Ababa, Ethiopia.MethodsA cross-sectional study design and systematic random sampling technique were used to recruit 408 participants at St. Paul’s Hospital Millennium Medical College and Yekatit-12 Hospital Medical College, Addis Ababa, Ethiopia. We collected the data by face-to-face interview. Devaluation of Consumer Families Scale was used to measure perceived stigma. Patient Health Questionnaire-9 and Oslo-3 social support scale were the instruments used to assess the factors. Coded variables were entered into Epidata V.3.1 and exported to SPSS V.21 for analysis. Binary logistic regression was used for analysis.ResultA total of 408 participants were interviewed, with a response rate of 96.5%. The magnitude of perceived stigma was 38.5% with 95% CI (33.6-43.1). Majority (68.6%) of the respondents were female. In the multivariate logistic regression, being mother (AOR = 2.8, 95% CI: 1.59, 4.91), absence of other caregiver (AOR = 2.0, 95% CI: 1.15, 3.49), poor social support (AOR = 3.9, 95% CI: 1.59, 6.13), and symptoms of depression (AOR = 2.9, 95% CI: 1.88, 3.65) were factors significantly associated with perceived stigma.ConclusionThe prevalence of perceived stigma among primary caregivers of children and adolescents with mental illness was high. Being mother, absence of other caregiver, poor social support, and symptoms of depression were factors significantly associated with perceived stigma.
Alcohol withdrawal syndrome in ICU patients: Clinical features, management, and outcome predictors
Authors: Vigouroux Aliénor , Garret Charlotte , Lascarrou Jean-Baptiste , Martin Maëlle , Miailhe Arnaud-Félix , Lemarié Jérémie , Dupeyrat Julien , Zambon Olivier , Seguin Amélie , Reignier Jean , Canet Emmanuel 
Published: December 2021

Background
Alcohol withdrawal syndrome (AWS) is a common condition in hospitalized patients, yet its epidemiology in the ICU remains poorly characterized.

Methods
Retrospective cohort of patients admitted to the Nantes University Hospital ICU between January 1, 2017, and December 31, 2019, and coded for AWS using ICD-10 criteria. The objective of the study was to identify factors associated with complicated hospital stay defined as ICU length of stay ≥7 days or hospital mortality.

Results
Among 5,641 patients admitted to the ICU during the study period, 246 (4.4%) were coded as having AWS. Among them, 42 had exclusion criteria and 204 were included in the study. The three main reasons for ICU admission were sepsis (29.9%), altered consciousness (29.4%), and seizures (24%). At ICU admission, median Cushman’s score was 6 [4–9] and median SOFA score was 3 [2–6]. Delirium tremens occurred in half the patients, seizures in one fifth and pneumonia in one third. Overall, 48% of patients developed complicated hospital stay, of whom 92.8% stayed in the ICU for ≥7 days, 36.7% received MV for ≥7 days, and 16.3% died during hospital stay. By multivariable analysis, two factors were associated with complicated hospital stay: a higher number of organ dysfunctions at ICU admission was associated with a higher risk of complicated hospital stay (OR, 1.18; 95CI, 1.05–1.32, P = 0.005), whereas ICU admission for seizures was associated with a lower risk of complicated hospital stay (OR, 0.14; 95%CI, 0.026–0.80; P = 0.026).

Conclusions
AWS in ICU patients chiefly affects young adults and is often associated with additional factors such as sepsis, trauma, or surgery. Half the patients experienced an extended ICU stay or death during the hospital stay. The likelihood of developing complicated hospital stay relied on the reason for ICU admission and the number of organ dysfunctions at ICU admission.
Difference in predictors and barriers to arts and cultural engagement with age in the United States: A cross-sectional analysis using the Health and Retirement Study
Authors: Fluharty Meg , Paul Elise , Bone Jessica , Bu Feifei , Sonke Jill , Fancourt Daisy 
Published: December 2021

Introduction
Arts and cultural engagement are associated with a range of mental and physical health benefits, including promoting heathy aging and lower incidence of age-related disabilities such as slower cognitive decline and slower progression of frailty. This suggests arts engagement constitutes health-promoting behaviour in older age. However, there are no large-scale studies examining how the predictors of arts engagement vary with age.

Methods
Data from the Health and Retirement Study (2014) were used to identify sociodemographic, life satisfaction, social, and arts appreciation predictors of (1) frequency of arts engagement, (2) cultural attendance, (3) difficulty participating in the arts, and (4) being an interested non-attendee of cultural events. Logistic regression models were stratified by age groups [50–59, 60–69, ≥70] for the frequency of arts participation outcome and [50–69 vs ≥70] all other outcomes.

Results
Findings indicated a number of age-related predictors of frequent arts engagement, including gender, educational attainment, wealth, dissatisfaction with aging, and instrumental activities of daily living (iADL). For cultural event attendance, lower interest in the arts predicted lack of engagement across age groups, whereas higher educational attainment and more frequent religious service attendance became predictors in older age groups (≥ 70). Adults in both age groups were less likely to report difficulties engaging in the arts if they had lower neighbourhood safety, whilst poor self-rated health and low arts appreciation also predicted reduced likelihood of this outcome, but only in the younger (50–69) age group. Adults in the older (≥ 70) age group were more likely to be interested non-attendees of cultural events if they had higher educational attainment and less likely if they lived in neighbourhoods with low levels of safety.

Conclusions
Our results suggest that certain factors become stronger predictors of arts and cultural engagement and barriers to engagement as people age. Further, there appear to be socioeconomic inequalities in engagement that may increase in older ages, with arts activities overall more accessible as individuals age compared to cultural engagement due to additional financial barriers and transportation barriers. Ensuring that these activities are accessible to people of all ages will allow older adults to benefit from the range of health outcomes gained from arts and cultural engagement.
3,4-Dihydroxyphenylethanol ameliorates lipopolysaccharide-induced septic cardiac injury in a murine model
Authors: Zhang Lu , Wen Kun , Zhang Zhiqiang , Ma Chengen , Zheng Ni 
Published: December 2021

Abstract
3,4-Dihydroxyphenylethanol (DOPET) is a polyphenol found in olive oil. The present study evaluated the protective role of DOPET on LPS provoked septic cardiac injury in a murine model. Four groups were used in the study (n = 3): control, LPS, DOPET alone, and DOPET + LPS. LPS (15 mg/kg; i.p.); they were used to induce cardiac sepsis. The cardiac markers like LDH, CK-MB, and troponin-T, as well as inflammatory cytokines like TNF-α and IL-6 were measured in the serum. The antioxidants and oxidative stress parameters were measured in cardiac tissues. RT-PCR and western blot methods were done to evaluate the expression of inflammatory mediators and apoptotic markers. DOPET significantly decreased the cardiac markers (LDH, CK-MB, and troponin-T) and TNF-α and IL-6 level in the serum. DOPET effectively reduced the levels of MDA and NO in LPS intoxicated rats. DOPET also increased the levels of antioxidants like SOD, CAT, GPx, and GSH in LPS intoxicated rats. The mRNA levels of TNF-α, IL-6, and NF-κB were significantly downregulated by DOPET in cardiac tissues of LPS rats. The protein expression of Bcl-2 was upregulated, and Bax and caspase-3 were downregulated by DOPET. DOPET effectively attenuates LPS-induced cardiac dysfunction through its antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.
Investigating the properties and performance of 3A molecular sieves as an adsorbent to prevent coke formation in olefin dehydration process
Authors: Moslempour Zoya , Sadighi Sepehr , Dashti Ali , Ahmadpour Ali 
Published: December 2021

Abstract
To study the affinity of 3A aluminosilicate adsorbents to prevent oligomerization of olefin molecules and forming green oil, physical and chemical properties of 3A molecular sieves are measured by using characterization techniques such as temperature-programmed desorption (TPD), nitrogen (N2) and water adsorptions, X-ray diffraction (XRD), X-ray fluorescence (XRF), crushing strength, and carbon dioxide (CO2) adsorption. Moreover, coke formation affinities of the understudy adsorbents are evaluated in a bench-scale system using 1-butene and 1,3-butadiene at temperatures of 220 and 260 °C, and outcomes are validated against the actual data gathered from an industrial scale olefin dehydration plant. Results confirm that the type of binder and the amount of ion exchange affect the performance of a 3A molecular sieve nominated for dehydrating olefinic streams. The binder with the least amount of acidity is preferred, and at least 35% of Na ions of the 4A zeolite should be exchanged with K ions to make it applicable for synthesizing an appropriate 3A molecular sieve. Furthermore, to control the oligomerization and inhibit green oil formation, the CO2 adsorption and acidity of Trisiv shape molecular sieves with the sizes of 1/4 inch should be less than 0.5 wt % and 1.7 mmol NH3/g, respectively. For extrudate shape with the sizes of 1/16 inch CO2 adsorption and acidity should be less than 0.2 wt % and 2.2 mmol NH3/g, respectively.
Patriarchy as Institutional
Authors: Brännmark Johan 
Published: December 2021

AbstractIn consideringpatriarchyas potentially institutional and as a characteristic also of contemporary Western societies, a fundamental issue concerns how to make sense of largely informal institutions to begin with. Traditional accounts of institutions have often focused on formalized ones. It is argued here, however, that the principal idea behind one commonly accepted conception of institutions can be developed in a way that better facilitates an explication of informal institutions. When applied to the phenomenon of patriarchy, such an approach can then also allow us to ontologically make sense of gray areas and hierarchies of authority, as well as the intersectionality of social positions.
Students’ Perceptions on Cataloging Course
Authors: Kyprianos Konstantinos , Efthymiou Foteini , Kouis Dimitrios 
Published: December 2021

Abstract
Cataloging and metadata description is one of the major competencies that a trainee cataloger must conquer. According to recent research results, library and information studies students experience difficulties understanding the theory, the terminology, and the tools necessary for cataloging. The experimental application of teaching models which derive from predominant learning theories, such as behaviorism, cognitivism, and constructivism, may help in detecting the difficulties of a cataloging course and in suggesting efficient solutions. This paper presents in detail three teaching models applied for a cataloging course and investigates their effectiveness, based on a survey of 126 first-year students. The survey employed the Kirkpatrick model aiming to record undergraduate students’ perceptions and feelings about cataloging. The results revealed that, although a positive change in students’ behavior towards cataloging has been achieved, they still do not feel very confident about the skills they have acquired. Moreover, students felt that practicing cataloging more frequently will eliminate their difficulties. Finally, they emphasized the need for face to face courses, as the survey took place in the coronavirus pandemic, during which the courses were held via distance learning.
Neurobiology of phenotypic plasticity in the light of climate change
Authors: Weiss Linda C. 
Published: December 2021

Abstract
Phenotypic plasticity describes the ability of an organism with a given genotype to respond to changing environmental conditions through the adaptation of the phenotype. Phenotypic plasticity is a widespread means of adaptation, allowing organisms to optimize fitness levels in changing environments. A core prerequisite for adaptive predictive plasticity is the existence of reliable cues, i.e. accurate environmental information about future selection on the expressed plastic phenotype. Furthermore, organisms need the capacity to detect and interpret such cues, relying on specific sensory signalling and neuronal cascades. Subsequent neurohormonal changes lead to the transformation of phenotype A into phenotype B. Each of these activities is critical for survival. Consequently, anything that could impair an animal’s ability to perceive important chemical information could have significant ecological ramifications. Climate change and other human stressors can act on individual or all of the components of this signalling cascade. In consequence, organisms could lose their adaptive potential, or in the worst case, even become maladapted. Therefore, it is key to understand the sensory systems, the neurobiology and the physiological adaptations that mediate organisms’ interactions with their environment. It is, thus, pivotal to predict the ecosystem-wide effects of global human forcing. This review summarizes current insights on how climate change affects phenotypic plasticity, focussing on how associated stressors change the signalling agents, the sensory systems, receptor responses and neuronal signalling cascades, thereby, impairing phenotypic adaptations.
“New Kids on the Block?” Reappraising Pottery Styles, aDNA, and Chronology from Western Iberia Early Neolithic
Authors: Diniz Mariana 
Published: December 2021

Abstract
Western Iberia Early Neolithic has been described as an ultimate and very altered form of the Mediterranean Neolithisation process. Despite its Atlantic position, this territory – corresponding mainly to Central/Southern Portugal – is, in its physical and cultural geography, a Mediterranean landscape deeply connected to a historical process arriving from beyond the Strait of Gibraltar. The presence of cardial pottery led archaeologists to ascribe Portuguese Early Neolithic to a Mediterranean impressed Pottery cultural area, and according to demic diffusion models, small pioneer groups carrying the Neolithic package originated there. Recently, the archaeological record for the Western Mediterranean Neolithisation is becoming more complex and longer lasting cardial dominance over the seas has been disputed. Previous Neolithic groups seafaring the Mediterranean coasts with Impressa style pottery could have reached Iberian Peninsula by 5600–5400 cal BC, proving that by the mid-sixth millennium, different cultural entities were moving in the Western Mediterranean regardless of their genetic features. The main goal of this study is to disclose this cultural diversity in Western Iberia using a robust chronological database and debating how different proxies, like pottery styles and ancient DNA (aDNA), reveal it in Western Iberia. While recognising the Mediterranean input to Western Iberia groups, mapping the variability and the significance of different decoration techniques, such as cardial, false acacia leaf, impressed stripes, and using the aDNA to identify continuities/changes in ancient populations are here as tools to understand when, who, and how new kids came to the block. To do so, different disciplinary boundaries are crossed, and some transdisciplinary critical aspects are also commented.
Glucose-6-phosphate dehydrogenase gene Ala365Thr mutation in an Iraqi family with confusing clinical differences
Authors: Ardicoglu Akisin Yasemin , Arslan Zafer , Ceylaner Serdar , Akar Nejat 
Published: December 2021

Abstract

Objectives
Glucose-6-phosphate dehydrogenase (G6PD) has role in the Embden Meyerhof road. Any loss of its function causes NADPH to cease, leaving erythrocytes susceptible to oxidative damage resulting in acute hemolytic anemia attacks secondary to drugs or infection and favism. Because of X-linked recessive inheritance males are mainly affected. Being heterozygous, females have less severe clinical presentation.

Case presentation
G6PD deficiency was suspected in a six-year-old girl from an Iraqi family with a history of yellowing of skin and darkening of urine after eating broad beans. Besides the patient, G6PD levels were found low in the father and in two sisters who showed no symptoms. The father was found hemizygous and the three sisters were found heterozygous for NM_000402.4c.1093G>A(p.A365T)(6.Ala365Thr) mutation while the mother was normal.

Conclusions
G6PD enzyme deficiency can be seen in both genders, and it may be presented with different clinical manifestations even within the people having the same mutation.
Maduración en poscosecha de frutos de aguacate cultivares Hass y Méndez tratados con etefón
Authors: Rosas Flores Nallely , Saucedo Veloz Crescenciano , Saucedo Reyes Daniela , López Jiménez Alfredo , Valle Guadarrama Salvador , Ramírez Guzmán Martha Elva , Chávez Franco Sergio Humberto 
Published: December 2021

Un problema en poscosecha de aguacate (Persea americana Mill.) es la heterogeneidad en la maduración de los frutos, debido a diferencias en el momento de amarre y la incapacidad para madurar en el árbol, situación que provoca inconsistencias en la calidad y diferencias en la respuesta a tecnologías de conservación y procesamiento. En poscosecha, la aplicación de gas etileno en cámaras herméticas se ha utilizado para adelantar la maduración; sin embargo, se ha propuesto como alternativa el uso de liberadores de etileno en forma líquida (etefón), principalmente para el tratamiento de bajos volúmenes de fruta. El presente trabajo fue realizado en la zona productora de Salvador Escalante (Michoacán, México) con el objetivo de evaluar el efecto de la aplicación de dos concentraciones de etefón en el tiempo y homogeneización de la maduración de frutos de los cultivares (cv.) de aguacate Hass y Méndez. Se cosecharon frutos con 23.4% (cv. Hass) y 24% (cv. Méndez) de materia seca; un grupo se sumergió en una solución de etefón 500 mg/l y otro, en 1000 mg/l, ambos durante 5 minutos; los frutos tratados, más un control fueron almacenados a 20 °C por 11 días. Se evaluaron cambios en la respiración, producción de etileno, pérdidas de peso, firmeza, color en epicarpio y en pulpa, concentración de fenoles totales, clorofila y carotenoides totales. Los resultados mostraron que las dosis de etefón de 1000 mg/l en cv. Hass y de 500 mg/l en cv. Méndez presentaron un proceso de maduración 2 días más temprano que el control.
Automated method of calculation of parameters for non-traditional heating technologies and conditioning of buildings
Authors: Olishevskyi Illia , Olishevskyi Hennadiy 
Published: December 2021

Purpose. Develop an automated method for calculating parameters for heat pump systems for heating, air conditioning and hot water supply, designed for use in domestic conditions with non-standard heat transfer flows.
Methodology. Mathematical modeling of thermodynamic processes occurring in heating, air conditioning and hot water supply systems.
Findings. The automated method of calculating the parameters of non-traditional technology, which uses standard heat pump equipment of the water heating system for the cooling mode of the air in the warm period of the year, and the discharge of heat dissipated into the ground, was substantiated and developed; and for the needs of hot water supply heat pump air-liquid, acting as a high-speed water heater.
The estimation of technologies of the thermal energy utilization in buildings developed earlier by authors is executed. The first technology involved the use of a heat pump and heat accumulator scheme in the cold season, and halved the consumption of conventional fuel compared to a gas column for hot water at the same facility. The second technology involved heat recovery with the help of a heat accumulator in a complex system of air conditioning and hot water supply in the warm period, which saves from 74 to 82% of conventional fuel compared to the scheme with boiler and air conditioner without heat accumulator.
Critical conclusions were drawn about the need to use additional dimensional equipment for these technologies and the excess amount of hot water received. Possibilities of realization of such scheme were analyzed. Analytically substantiated recommendations on the design (ribbing of heat exchange surfaces) of heating devices and parameters of their operating modes in the cold and warm periods of the year were given. The condition of invariance of heat exchange areas of heating devices and basic water consumption in the heating system was fulfilled. The need to regulate the air conditioning regime by changing the water flow in the system to maintain a constant indoor air temperature with fluctuations in outdoor air temperature was substantiated.
Originality. For the first time, attention is paid to the study of non-traditional methods of using heat pump heating for heating, air conditioning and hot water supply of residential premises. The automated method for determining rational parameters for these technologies was developed.
Practical value. The automated method of forming the control dependence of the mass flow of water in the system on the outside air temperature on the condition of constancy of the set comfortable indoor air temperature was developed. The use of air-liquid heat pump for hot water supply in the warm period was analyzed, a high energy conversion factor was noted (14 ... 22). The savings of conventional fuel from the application of the considered technology from 13% to 18% in comparison with the technology using a heat accumulator were substantiated.