bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative chemoradiotherapy with cisplatin is superior to radioimmunotherapy with cetuximab and radiotherapy alone
Authors: Magnes Teresa , Wagner Sandro M. , Melchardt Thomas , Weiss Lukas , Rinnerthaler Gabriel , Huemer Florian , Kopp Michael , Gampenrieder Simon Peter , Mayrbäurl Beate , Füreder Thorsten , Lenger Daniel , Andel Johannes , Egle Alexander , Greil Richard 
Published: September 2021

Summary
Background
The addition of cisplatin or cetuximab to radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) has significantly improved the outcome. While the superiority of cisplatin over cetuximab in combination with radiotherapy has been shown in a definitive setting, we set out to compare postoperative chemoradiotherapy with cisplatin to radioimmunotherapy with cetuximab and radiotherapy alone within the Austrian head and neck cancer registry of the Working Group on Pharmaceutical Tumor Treatment (AGMT) study group.

Material and methods
In the AGMT head and neck cancer registry, data of 557 patients with SCCHN from five Austrian cancer centers were prospectively collected between 2012 and 2017. Of these patients 120 received postoperative chemoradiotherapy with cisplatin, 26 patients received postoperative radioimmunotherapy with cetuximab and 56 patients were treated with adjuvant radiotherapy only. Patient characteristics, stage of disease, details on treatment as well as survival were analyzed by a chart-based review.

Results
In patients treated with postoperative radiotherapy the addition of cisplatin significantly improved progression-free survival (PFS) and overall survival (OS) compared to cetuximab (PFS 84.2 months vs. 17.0 months, p = 0.04, OS not reached vs. 46.0 months, p = 0.02) and PFS compared to radiotherapy alone (PFS 84.2 months vs. 28.5 months, p < 0.01). Patients treated with cetuximab were significantly older and had a worse performance score than patients receiving cisplatin or radiotherapy alone.

Conclusion
This study confirmed the importance of multimodal treatment concepts in patients with locally advanced SCCHN. Postoperative cetuximab might be an option in patients not eligible for high-dose cisplatin but cisplatin should remain the standard of care.
Spatial distribution and interannual variability of coastal fog and low clouds cover in the hyperarid Atacama Desert and implications for past and present Tillandsia landbeckii ecosystems
Authors: del Río Camilo , Lobos-Roco Felipe , Latorre Claudio , Koch Marcus A. , García Juan-Luis , Osses Pablo , Lambert Fabrice , Alfaro Fernando , Siegmund Alexander 
Published: September 2021

AbstractThe hyperarid Atacama Desert coast receives scarce moisture inputs mainly from the Pacific Ocean in the form of marine advective fog. The collected moisture supports highly specialized ecosystems, where the bromeliad Tillandsia landbeckii is the dominant species. The fog and low clouds (FLCs) on which these ecosystems depend are affected in their interannual variability and spatial distribution by global phenomena, such as ENSO. Yet, there is a lack of understanding of how ENSO influences recent FLCs spatial changes and their interconnections and how these variations can affect existing Tillandsia stands. In this study, we analyze FLCs occurrence, its trends and the influence of ENSO on the interannual variations of FLCs presence by processing GOES satellite images (1995–2017). Our results show that ENSO exerts a significant influence over FLCs interannual variability in the Atacama at ~ 20°S. Linear regression analyses reveal a relation between ENSO3.4 anomalies and FLCs with opposite seasonal effects depending on the ENSO phase. During summer (winter), the ENSO warm phase is associated with an increase (decrease) of the FLCs occurrence, whereas the opposite occurs during ENSO cool phases. In addition, the ONI Index explains up to ~ 50 and ~ 60% variance of the interannual FLCs presence in the T. landbeckii site during summer and winter, respectively. Finally, weak negative (positive) trends of FLCs presence are observed above (below) 1000 m a. s. l. These results have direct implications for understanding the present and past distribution of Tillandsia ecosystems under the extreme conditions characterizing our study area.
A trigonal coordination of Au(I) phosphane complexes stabilized by O–H⋯X (X = Cl–, Br–, I–) interactions
Authors: Gründlinger Petra , Mardare Cezarina Cela , Wagner Thorsten , Monkowius Uwe 
Published: September 2021

AbstractIn this work, we show that intramolecular hydrogen bonding can be used to stabilize tri-coordinated phosphane-gold(I) complexes. Two molecular structures of 2-(diphenylphosphino)benzoic acid (L) coordinated to a gold(I) atom were determined by single-crystal X-ray diffraction. The linear L–Au–Br shows a standard linear coordination and dimerizes via hydrogen bonds of the carboxylic acid. Upon addition of two additional phosphane ligands the complex [L3Au]X is formed which is stabilized by three intramolecular –C(O)O–H…X hydrogen bonds as proven by the X-ray structure of the respective chlorido-complex. X-ray powder diffractograms suggest the same structure also for X– = Br– and I–.
Graphic abstract
Recruitment of scarce competences to rural regions: Policy perspectives
Authors: Nyström Kristina 
Published: September 2021

AbstractThis paper studies the perceived difficulty of recruiting scarce competencies to rural regions. Furthermore, the role of policy in facilitating and enhancing recruitment to and better skills matching in rural regions is discussed. Based on a survey targeted to the business sections of Swedish municipalities, the results show that recruitment is perceived to be difficult in both rural and nonrural regions and that the difficulty of recruiting for the right skills results in a lack of skills matching and constitutes an obstacle to growth. Rural regions located close to urban areas can to some extent mitigate these recruitment problems, and their locations pose less of a barrier in recruitment processes compared to those of remotely located rural regions.Which policies can help remedy recruitment problems faced in rural regions? In both rural and nonrural regions, incentives for writing off student debt and relocation support for accompanying persons and tandem recruitment are perceived to be the most promising policies. Rural regions are more receptive to the implementation of such policies. Finally, the need for flexibility and policies that can be adapted to the regional demand for labour are stressed.
Online network monitoring
Authors: Malinovskaya Anna , Otto Philipp 
Published: September 2021

AbstractAn important problem in network analysis is the online detection of anomalous behaviour. In this paper, we introduce a network surveillance method bringing together network modelling and statistical process control. Our approach is to apply multivariate control charts based on exponential smoothing and cumulative sums in order to monitor networks generated by temporal exponential random graph models (TERGM). The latter allows us to account for temporal dependence while simultaneously reducing the number of parameters to be monitored. The performance of the considered charts is evaluated by calculating the average run length and the conditional expected delay for both simulated and real data. To justify the decision of using the TERGM to describe network data, some measures of goodness of fit are inspected. We demonstrate the effectiveness of the proposed approach by an empirical application, monitoring daily flights in the United States to detect anomalous patterns.
Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization
Authors: Ben Dhaou Cyrine , Mandi Kamel , Frye Mickaël , Acheampong Angela , Radi Ayoub , De Becker Benjamin , Antoine Mathieu , Baeyens Nicolas , Wittamer Valérie , Parmentier Marc 
Published: September 2021

AbstractChemerin is a multifunctional protein initially characterized in our laboratory as a chemoattractant factor for leukocyte populations. Its main functional receptor is CMKLR1. We identified previously chemerin as an anti-tumoral factor inhibiting the vascularization of tumor grafts. We show here that overexpression of bioactive chemerin in mice results in a reduction of the density of the retinal vascular network during its development and in adults. Chemerin did not affect vascular sprouting during the post-natal development of the network, but rather promoted endothelial cell apoptosis and vessel pruning. This phenotype was reversed to normal in CMKLR1-deficient mice, demonstrating the role of this receptor. Chemerin inhibited also neoangiogenesis in a model of pathological proliferative retinopathy, and in response to hind-limb ischemia. Mechanistically, PTEN and FOXO1 antagonists could almost completely restore the density of the retinal vasculature, suggesting the involvement of the PI3-kinase/AKT pathway in the chemerin-induced vessel regression process.
BBW: a batch balance wrapper for training deep neural networks on extremely imbalanced datasets with few minority samples
Authors: Hu Jingzhao , Zhang Hao , Liu Yang , Sutcliffe Richard , Feng Jun 
Published: September 2021

AbstractIn recent years, Deep Neural Networks (DNNs) have achieved excellent performance on many tasks, but it is very difficult to train good models from imbalanced datasets. Creating balanced batches either by majority data down-sampling or by minority data up-sampling can solve the problem in certain cases. However, it may lead to learning process instability and overfitting. In this paper, we propose the Batch Balance Wrapper (BBW), a novel framework which can adapt a general DNN to be well trained from extremely imbalanced datasets with few minority samples. In BBW, two extra network layers are added to the start of a DNN. The layers prevent overfitting of minority samples and improve the expressiveness of the sample distribution of minority samples. Furthermore, Batch Balance (BB), a class-based sampling algorithm, is proposed to make sure the samples in each batch are always balanced during the learning process. We test BBW on three well-known extremely imbalanced datasets with few minority samples. The maximum imbalance ratio reaches 1167:1 with only 16 positive samples. Compared with existing approaches, BBW achieves better classification performance. In addition, BBW-wrapped DNNs are 16.39 times faster, relative to unwrapped DNNs. Moreover, BBW does not require data preprocessing or additional hyper-parameter tuning, operations that may require additional processing time. The experiments prove that BBW can be applied to common applications of extremely imbalanced data with few minority samples, such as the classification of EEG signals, medical images and so on.
Detection of Borrelia burgdorferi s.l., Anaplasma phagocytophilum and Babesia spp. in Dermacentor reticulatus ticks found within the city of Białystok, Poland—first data
Authors: Grochowska Anna , Dunaj Justyna , Pancewicz Sławomir , Czupryna Piotr , Majewski Piotr , Wondim Mulugeta , Tryniszewska Elżbieta , Moniuszko-Malinowska Anna 
Published: September 2021

AbstractPathogens carried by ticks pose a threat to both human and animal health across the world. Typically associated with rural landscapes, ticks appear to adapt well to life in urban recreational areas. Although Dermacentor reticulatus is commonly found across Europe, data on the prevalence of pathogens in this tick species, in an urban environment, are very limited. PCR was used to examine 368 D. reticulatus individuals collected in the Zwierzyniecki Forest Nature Reserve in Białystok, Poland. In total, 10.3% of ticks were infected, with Babesia spp. (9.2%), Anaplasma phagocytophilum (0.8%) and Borrelia burgdorferi sensu lato (0.3%). Rickettsia spp., Bartonella spp., and Coxiella burnetii were not detected. Sequence analysis for Babesia-positive samples identified 79.4% of them as Babesia canis, 8.8% as Babesia microti, 5.9% as Babesia spp., 2.9% as Babesia venatorum, and 2.9% as Babesia vogeli. Results obtained in this study indicate that D. reticulatus ticks found within the urban premises of the study area are infected with at least three pathogens and therefore are an important factor in public health risk for tick-borne diseases.
Unsupervised law article mining based on deep pre-trained language representation models with application to the Italian civil code
Authors: Tagarelli Andrea , Simeri Andrea 
Published: September 2021

AbstractModeling law search and retrieval as prediction problems has recently emerged as a predominant approach in law intelligence. Focusing on the law article retrieval task, we present a deep learning framework named LamBERTa, which is designed for civil-law codes, and specifically trained on the Italian civil code. To our knowledge, this is the first study proposing an advanced approach to law article prediction for the Italian legal system based on a BERT (Bidirectional Encoder Representations from Transformers) learning framework, which has recently attracted increased attention among deep learning approaches, showing outstanding effectiveness in several natural language processing and learning tasks. We define LamBERTa models by fine-tuning an Italian pre-trained BERT on the Italian civil code or its portions, for law article retrieval as a classification task. One key aspect of our LamBERTa framework is that we conceived it to address an extreme classification scenario, which is characterized by a high number of classes, the few-shot learning problem, and the lack of test query benchmarks for Italian legal prediction tasks. To solve such issues, we define different methods for the unsupervised labeling of the law articles, which can in principle be applied to any law article code system. We provide insights into the explainability and interpretability of our LamBERTa models, and we present an extensive experimental analysis over query sets of different type, for single-label as well as multi-label evaluation tasks. Empirical evidence has shown the effectiveness of LamBERTa, and also its superiority against widely used deep-learning text classifiers and a few-shot learner conceived for an attribute-aware prediction task.
On the role of N-methylmorpholine-N-oxide (NMMO) in the generation of elemental transition metal precipitates in cellulosic materials
Authors: Rosenau Thomas , Potthast Antje , Hettegger Hubert , Bacher Markus , Opietnik Martina , Röder Thomas , Adorjan Immanuel 
Published: September 2021

AbstractSeveral literature reports describe the role of aqueous solutions ofN-methylmorpholine-N-oxide monohydrate (NMMO) as a suitable medium for the generation of transition metal (nano)particles in or on cellulosic materials and further elaborate its role as a co-reactant of the transition metal salts that are reduced to the elemental metal. However, this would assign NMMO the role of a reductant, which is in contradiction of its obvious oxidative nature. In the present study, the exemplary cases of silver, gold, and platinum salts as the precursors of the respective metal (nano)particles in aqueous NMMO/cellulose mixtures were investigated. Naturally, NMMO did not act as a reducing agent in any case—this role was taken over by the frequently used NMMO stabilizer propyl gallate, or by cellulose itself, into which carbonyl and carboxyl groups were introduced. Also, hypochlorite—produced intermediately from chloride ions and subsequently undergoing disproportionation into chloride and chlorate—or transientN-methylene(morpholinium) ions generated from NMMO, which are in turn oxidized to formyl morpholide, can act as the corresponding reductants while the metal ions are reduced, depending on the reaction conditions. Apart from providing interesting mechanistic insights, the study points to the importance of a precise description of the composition of the chemical systems used, as well as the importance of seemingly inert auxiliaries, which turned out to be essential co-reactants in the metal (nano)particle generation.Graphic abstract
Paramylon extracted from Euglena gracilis EOD-1 augmented the expression of SIRT1
Authors: Ieiri Hiromi , Kameda Natsuki , Naito Junko , Kawano Takanori , Nishida Norihisa , Takahashi Madoka , Katakura Yoshinori 
Published: September 2021

AbstractEuglena gracilis, a type of microalgae, contains several nutrients and accumulates paramylon, a β-1,3-glucan. In recent studies, paramylon has shown to exhibit various activities including immunomoduratory and hepatoprotective effects. In the present study, using an in vitro cell culture system, we aimed to determine whether paramylon derived from the E. gracilis EOD-1 strain, which produces large amounts of paramylon, can augment SIRT1 expression in epidermal cells via activating gut–skin interactions. Results showed that paramylon augmented the expression of SIRT1 in Caco-2 cells, a human intestinal cell line. Furthermore, microarray analysis of Caco-2 cells treated with paramylon showed that paramylon activates epidermal cells through inducing the secretion of factors from intestinal cells. Then, we focused on skin cells as target cells of paramylon-activated intestinal cells. Results showed that secretory factors from Caco-2 cells treated with paramylon augmented the expression of SIRT1 in HaCaT cells, a human keratinocyte cell line, and that expression level of genes related to the growth and maintenance of epidermal cells were significantly changed in Caco-2 cells treated with paramylon as evidenced by microarray analysis. All these results suggest that paramylon can activate epidermal cells by inducing the production of secretory factors from intestinal cells.
Deliberative structures and their impact on voting under economic conflict
Authors: Brandts Jordi , Gerhards Leonie , Mechtenberg Lydia 
Published: September 2021

AbstractWe conduct a laboratory experiment to investigate how different deliberative structures of varying inclusiveness affect collective decisions in the presence of economic conflict. An electorate consists of two groups, one informed and one uninformed about an uncertain state of the economy. This state affects payoffs differently for the two groups. We study three deliberative structures that vary in how the uninformed are included in pre-vote communication. Compared with a setting without any communication, we find that communication in all three deliberation treatments leads to more frequent votes for the efficient policies. The most inclusive deliberative structure motivates more truthfulness, more trust, more cooperativeness (i.e. refraining from protest votes), and more votes for the efficient policies, than the least inclusive structure. However, comparison among the deliberation treatments reveals that the most inclusive deliberative structure is not the one that generates the highest degree of truthfulness. The dynamics of communication lead to a general deterioration of truth-telling and cooperativeness, reinforced by the use of disrespectful and uncooperative language.
Stromal cell-derived factor (SDF)-1α and platelet-rich plasma enhance bone regeneration and angiogenesis simultaneously in situ in rabbit calvaria
Authors: Zhang Zhengye , Zheng Yang , Zu Jianing , Zhuang Jinpeng , Xu Gongping , Yan Jinglong , Liu Xiaoqi 
Published: September 2021

AbstractThe current study aimed to evaluate the effects of chemokine stromal cell-derived factor (SDF)-1α and platelet-rich plasma (PRP) on bone formation and angiogenesis, and to assess whether SDF-1α and PRP could function synergistically. Four evenly distributed defects (8 mm in diameter) were generated in the calvarial bones of New Zealand white rabbits. All rabbits received four treatment regimens containing autogenous bone particles (AB), SDF-1α, or PRP. AB group presented significantly less bone formation compared with the other three groups 2 and 4 weeks after surgery. The amount of newly formed bone in the AB+PRP+SDF-1α group was similar to that in the AB + SDF-1α group at the 4-week time-point (p = 0.65), and was much greater than that in the AB and AB+PRP group (p < 0.001). Meanwhile, more new blood vessels were formed in the AB+PRP, AB+SDF-1α, and AB+PRP+SDF-1α group versus the AB group. AB+PRP+SDF-1α group showed statistically increased angiogenesis compared with the AB+PRP and AB+SDF-1α groups (bothp < 0.05) after treatment for 2 and 4 weeks. These findings indicated that SDF-1α and PRP might exhibit synergistic effects to promote angiogenesis in early bone regeneration.
Dying like a dog: the convergence of concepts of a good death in human and veterinary medicine
Authors: Selter Felicitas , Persson Kirsten , Risse Johanna , Kunzmann Peter , Neitzke Gerald 
Published: September 2021

AbstractStandard views of good death in human and veterinary medicine considerably differ from one another. Whereas the good death ideal in palliative medicine emphasizes the positive aspects of non-induced dying, veterinarians typically promote a quick and painless killing with the aim to end suffering. Recent developments suggest a convergence of both professions and professional attitudes, however. Palliative physicians are confronted with patients wishing to be ‘put to sleep’, while veterinarians have begun to integrate principles and practices from hospice care. We will argue that the discourses on good human and animal deaths are not distinct, but that they interact and influence each other. On the one hand, veterinary medicine adapts techniques like chemotherapy or sedation from palliative end-of-life care. On the other hand, philosophers, veterinarians, pet owners, patients and the general public alike make certain assumptions about the (dis)analogy of human and animal dying or killing. Unfortunately, these interactions have only scarcely been reflected normatively, especially on the part of human medicine. Conflicts and misattributions with potential serious negative consequences for the (animal and human) patients’ wellbeing are provoked. For these reasons, palliative physicians and veterinarians are invited to engage in the debate around human and animal end-of-life care.
One or two? A Process View of pregnancy
Authors: Meincke Anne Sophie 
Published: September 2021

AbstractHow many individuals are present where we see a pregnant individual? Within a substance ontological framework, there are exactly two possible answers to this question. The standard answer—two individuals—is typically championed by scholars endorsing the predominant Containment View of pregnancy, according to which the foetus resides in the gestating organism like in a container. The alternative answer—one individual—has recently found support in the Parthood View, according to which the foetus is a part of the gestating organism. Here I propose a third answer: a pregnant individual is neither two individuals nor one individual but something in between one and two. This is because organisms are better understood as processes than as substances. With a special focus on the Parthood View, I explain why a Process View of pregnancy, according to which a pregnant individual is a bifurcating hypercomplex process, surpasses the substance ontological approaches.