bluuebunny/crossref_metadata_2025_split huggingface dataset:
Well-posedness analysis of multicomponent incompressible flow models
Authors: Bothe Dieter , Druet Pierre-Etienne 
Published: May 2021

AbstractIn this paper, we extend our study of mass transport in multicomponent isothermal fluids to the incompressible case. For a mixture, incompressibility is defined as the independence of average volume on pressure, and a weighted sum of the partial mass densities stays constant. In this type of models, the velocity field in the Navier–Stokes equations is not solenoidal and, due to different specific volumes of the species, the pressure remains connected to the densities by algebraic formula. By means of a change of variables in the transport problem, we equivalently reformulate the PDE system as to eliminate positivity and incompressibility constraints affecting the density, and prove two type of results: the local-in-time well-posedness in classes of strong solutions, and the global-in-time existence of solutions for initial data sufficiently close to a smooth equilibrium solution.
Simulation of the ductile machining mode of silicon
Authors: Klippel Hagen , Süssmaier Stefan , Röthlin Matthias , Afrasiabi Mohamadreza , Pala Uygar , Wegener Konrad 
Published: May 2021

AbstractDiamond wire sawing has been developed to reduce the cutting loss when cutting silicon wafers from ingots. The surface of silicon solar cells must be flawless in order to achieve the highest possible efficiency. However, the surface is damaged during sawing. The extent of the damage depends primarily on the material removal mode. Under certain conditions, the generally brittle material can be machined in ductile mode, whereby considerably fewer cracks occur in the surface than with brittle material removal. In the presented paper, a numerical model is developed in order to support the optimisation of the machining process regarding the transition between ductile and brittle material removal. The simulations are performed with an GPU-accelerated in-house developed code using mesh-free methods which easily handle large deformations while classic methods like FEM would require intensive remeshing. The Johnson-Cook flow stress model is implemented and used to evaluate the applicability of a model for ductile material behaviour in the transition zone between ductile and brittle removal mode. The simulation results are compared with results obtained from single grain scratch experiments using a real, non-idealised grain geometry as present in the diamond wire sawing process.
Automated, flow-based chemiluminescence microarray immunoassay for the rapid multiplex detection of IgG antibodies to SARS-CoV-2 in human serum and plasma (CoVRapid CL-MIA)
Authors: Klüpfel Julia , Koros Rosa Carolina , Dehne Kerstin , Ungerer Martin , Würstle Silvia , Mautner Josef , Feuerherd Martin , Protzer Ulrike , Hayden Oliver , Elsner Martin , Seidel Michael 
Published: May 2021

AbstractIn the face of the COVID-19 pandemic, the need for rapid serological tests that allow multiplexing emerged, as antibody seropositivity can instruct about individual immunity after an infection with SARS-CoV-2 or after vaccination. As many commercial antibody tests are either time-consuming or tend to produce false negative or false positive results when only one antigen is considered, we developed an automated, flow-based chemiluminescence microarray immunoassay (CL-MIA) that allows for the detection of IgG antibodies to SARS-CoV-2 receptor-binding domain (RBD), spike protein (S1 fragment), and nucleocapsid protein (N) in human serum and plasma in less than 8 min. The CoVRapid CL-MIA was tested with a set of 65 SARS-CoV-2 serology positive or negative samples, resulting in 100% diagnostic specificity and 100% diagnostic sensitivity, thus even outcompeting commercial tests run on the same sample set. Additionally, the prospect of future quantitative assessments (i.e., quantifying the level of antibodies) was demonstrated. Due to the fully automated process, the test can easily be operated in hospitals, medical practices, or vaccination centers, offering a valuable tool for COVID-19 serosurveillance.
Acoustic radiation force impulse imaging: normal values of spleen stiffness in healthy children
Authors: Hanquinet Sylviane , Habre Céline , Laurent Méryle , Anooshiravani Mehrak , Toso Seema 
Published: May 2021

Abstract
Background
Acoustic radiation force impulse (ARFI) imaging is a noninvasive ultrasound elastography technique for evaluating tissue stiffness. The association of liver and spleen stiffness provides additional information in the assessment of portal hypertension. The technique and normal values of spleen stiffness by point shear wave elastography (p-SWE) in pediatrics have not been well documented.

Objective
Our aim is to describe the feasibility and normal ARFI elastography values in the spleen for healthy children and to compare measurements in two different probe positions (the axial and sagittal planes).

Materials and methods
Spleen p-SWE using ARFI values were measured with a 6C1 probe in 102 healthy children (age range: 8 weeks to 17 years) divided into four age groups. An average of nine (standard deviation: two) spleen stiffness measurements were taken during free breathing in each plane (axial and sagittal). The impact of age and measurement plane in the spleen was analyzed using multivariate models.

Results
There was no significant difference in spleen stiffness values taken at different ages, with an average of the medians of 2.43±0.31 m/s. There was no significant difference based on probe orientation: sagittal plane (median: 2.46±0.29 m/s) and axial plane (median: 2.43±0.32 m/s) with Student’s t-test P=0.18. The mean depth of measurement varied between 2.3 cm and 3.7 cm, according to age.

Conclusion
Normal spleen stiffness values using ARFI imaging in children do not vary with age and correspond to a median of 2.43 m/s. No significant difference was found when using different probe positions.
Increasing coral calcification in Orbicella faveolata and Pseudodiploria strigosa at Flower Garden Banks, Gulf of Mexico
Authors: Manzello Derek P. , Kolodziej Graham , Kirkland Amanda , Besemer Nicole , Enochs Ian C. 
Published: May 2021

AbstractCoral reefs are globally in decline and western Atlantic reefs have experienced the greatest losses in live coral cover of any region. The Flower Garden Banks (FGB) in the Gulf of Mexico are high-latitude, remote reefs that are an outlier to this trend, as they have maintained coral cover ≥ 50% since at least 1989. Quantifying the long-term trends in coral growth of key reef-building coral species, and the underlying environmental drivers, leads to a better understanding of local sensitivities to past changes that will ultimately allow us to better predict the future of reef growth at FGB. We obtained coral cores and constructed growth records for two of the most abundant hermatypic coral species at FGB, Pseudodiploria strigosa and Orbicella faveolata. Our records cover 57 yrs of growth for P. strigosa (1957–2013) and 45 yrs for O. faveolata (1970–2014). Linear extension and calcification rates of both species have increased significantly, but skeletal density did not change over the respective time periods. Extension and calcification data of both species combined were negatively correlated with the discharge from the Atchafalaya River, but positively correlated with maximum sea surface temperatures (SST). These data provide evidence that runoff from the Atchafalaya River impacts FGB corals and is a major control on coral growth at FGB. The increase in growth at FGB can be attributed to the significant warming trend in maximum monthly SSTs. Given the warming trend and recent increase in severity of bleaching at FGB, the prognosis is that bleaching events will become more deleterious with time, which will lead to a breakdown in the positive relationship between coral growth and maximum SST. This study provides further evidence that some high-latitude, cooler reef sites have experienced a stimulation in coral growth with ocean warming.
A multivariate intersection over union of SiamRPN network for visual tracking
Authors: Huang Zhihui , Zhao Huimin , Zhan Jin , Li Huakang 
Published: May 2021

AbstractSiamPRN algorithm performs well in visual tracking, but it is easy to drift under occlusion and fast motion scenes because it uses $$\ell _1$$

ℓ
1

-smooth loss function to measure the regression location of bounding box. In this paper, we propose a multivariate intersection over union (MIOU) loss in SiamRPN tracking framework. Firstly, MIOU loss includes three geometric factors in regression: the overlap area ratio, the center distance ratio, and the aspect ratio, which can better reflect the coincidence degree of target box and prediction box. Secondly, we improve the definition of aspect ratio loss to avoid gradient explosion, improve the optimization performance of prediction box. Finally, based on SiamPRN tracker, we compared the tracking performance of $$\ell _1$$

ℓ
1

-smooth loss, IOU loss, GIOU loss, DIOU loss, and MIOU loss. Experimental results show that the MIOU loss has better target location regression than other loss functions on the OTB2015 and VOT2016 benchmark, especially for the challenges of occlusion, illumination change and fast motion.
Timely and individualized heart failure management: need for implementation into the new guidelines
Authors: Abdin Amr , Bauersachs Johann , Frey Norbert , Kindermann Ingrid , Link Andreas , Marx Nikolaus , Lainscak Mitja , Slawik Jonathan , Werner Christian , Wintrich Jan , Böhm Michael 
Published: May 2021

AbstractDue to remarkable improvements in heart failure (HF) management over the last 30 years, a significant reduction in mortality and hospitalization rates in HF patients with reduced ejection fraction (HFrEF) has been observed. Currently, the optimization of guideline-directed chronic HF therapy remains the mainstay to further improve outcomes for patients with HFrEF to reduce mortality and HF hospitalization. This includes established device therapies, such as implantable defibrillators and cardiac resynchronization therapies, which improved patients' symptoms and prognosis. Over the last 10 years, new HF drugs have merged targeting various pathways, such as those that simultaneously suppress the renin–angiotensin–aldosterone system and the breakdown of endogenous natriuretic peptides (e.g., sacubitril/valsartan), and those that inhibit theIfchannel and, thus, reduce heart rate (e.g., ivabradine). Furthermore, the treatment of patient comorbidities (e.g., iron deficiency) has shown to improve functional capacity and to reduce hospitalization rates, when added to standard therapy. More recently, other potential treatment mechanisms have been explored, such as the sodium/glucose co-transporter inhibitors, the guanylate cyclase stimulators and the cardiac myosin activators. In this review, we summarize the novel developments in HFrEF pharmacological and device therapy and discuss their implementation strategies into practice to further improve outcomes.
Retronasal olfactory testing in early diagnosed and suspected COVID-19 patients: a 7-week follow-up study
Authors: Prem Bernhard , Liu David Tianxiang , Besser Gerold , Renner Bertold , Mueller Christian Albert 
Published: May 2021

Abstract
Objectives
Olfactory dysfunction (OD) constitutes a major symptom in Coronavirus Disease 2019 (COVID-19). Yet, most data on smell loss rely on the evaluation of orthonasal olfactory performance. Therefore, we aimed to assess retronasal olfactory function (ROF) over a period of several weeks in proven and suspected COVID-19 patients.

Methods
One hundred and one subjects with suspected or laboratory-proven COVID-19 participated in this study. In patients with OD no longer than 4 weeks after initial symptom onset, ROF was measured with the 7-item Candy Smell Test ten times over 7 weeks.

Results
Olfactory function was decreased in the investigated patients and remained decreased over the course of 7 weeks. One-way repeated-measures ANOVA revealed no significant difference of ROF between different measurement time points. However, self-assessment of smell and flavour improved significantly (p = 0.013 and p = 0.043), but did not show complete recovery.

Conclusion
The current investigation revealed significant improvements in subjective smell and flavour perception over the course of 7 weeks in proven and suspected COVID-19 patients suffering from acute OD. However, objectively measured ROF based on a screening test revealed no improvements within the same time period.
Fear conditioning and stimulus generalization in association with age in children and adolescents
Authors: Reinhard Julia , Slyschak Anna , Schiele Miriam A. , Andreatta Marta , Kneer Katharina , Reif Andreas , Domschke Katharina , Gamer Matthias , Pauli Paul , Deckert Jürgen , Romanos Marcel 
Published: May 2021

AbstractThe aim of the study was to investigate age-related differences in fear learning and generalization in healthy children and adolescents (n = 133), aged 8–17 years, using an aversive discriminative fear conditioning and generalization paradigm adapted from Lau et al. (2008). In the current task, participants underwent 24 trials of discriminative conditioning of two female faces with neutral facial expressions, with (CS+) or without (CS−) a 95-dB loud female scream, presented simultaneously with a fearful facial expression (US). The discriminative conditioning was followed by 72 generalization trials (12 CS+, 12 GS1, 12 GS2, 12 GS3, 12 GS4, and 12 CS−): four generalization stimuli depicting gradual morphs from CS+ to CS− in 20%-steps were created for the generalization phases. We hypothesized that generalization in children and adolescents is negatively correlated with age. The subjective ratings of valence, arousal, and US expectancy (the probability of an aversive noise following each stimulus), as well as skin conductance responses (SCRs) were measured. Repeated-measures ANOVAs on ratings and SCR amplitudes were calculated with the within-subject factors stimulus type (CS+, CS−, GS1-4) and phase (Pre-Acquisition, Acquisition 1, Acquisition 2, Generalization 1, Generalization 2). To analyze the modulatory role of age, we additionally calculated ANCOVAs considering age as covariate. Results indicated that (1) subjective and physiological responses were generally lower with increasing age irrespective to the stimulus quality, and (2) stimulus discrimination improved with increasing age paralleled by reduced overgeneralization in older individuals. Longitudinal follow-up studies are required to analyze fear generalization with regard to brain maturational aspects and clarify whether overgeneralization of conditioned fear promotes the development of anxiety disorders or vice versa.
Radical scavenger competition of alizarin and curcumin: a mechanistic DFT study on antioxidant activity
Authors: Sadatsharifi Malek , Purgel Mihály 
Published: May 2021

AbstractIn vivo hydroxyl, peroxyl, and superoxide free radicals caused by oxidative stress can be toxic to molecules that are essential for the human body. However, there are natural compounds that can decrease the amount of these harmful species. In this work, we are focusing on two well-known compounds, alizarin (red) and curcumin, to study their interactions with these small radicals for a comparison between a rigid and a flexible structure. We made a mechanistic study and found the major and minor degradation products of curcumin as well as the autoxidation products of it based on a wide range of literature. We found several more favored pathways than those that were previously proposed. On the contrary, for degradation/oxidation of alizarin, only a few proposed mechanisms can be found which were performed in specific conditions. Our calculations predicted some favored rearrangements for the alizarin by peroxyl and superoxide radicals.
Graphical abstract
Common patterns in the molecular phylogeography of western palearctic birds: a comprehensive review
Authors: Pârâu Liviu G. , Wink Michael 
Published: May 2021

AbstractA plethora of studies have offered crucial insights in the phylogeographic status of Western Palearctic bird species. However, an overview integrating all this information and analyzing the combined results is still missing. In this study, we compiled all published peer-reviewed and grey literature available on the phylogeography of Western Palearctic bird species. Our literature review indicates a total number of 198 studies, with the overwhelming majority published as journal articles (n = 186). In total, these literature items offer information on 145 bird species. 85 of these species are characterized by low genetic differentiation, 46 species indicate genetic variation but no geographic structuring i.e. panmixia, while 14 species show geographically distinct lineages and haplotypes. Majority of bird species inhabiting the Western Palearctic display genetic admixture. The glaciation cycles in the past few million years were pivotal factors in shaping this situation: during warm periods many species expanded their distribution range to the north over wide areas of Eurasia; whereas, during ice ages most areas were no longer suitable and species retreated to refugia, where lineages mixed.
Symbiosis with artificial intelligence via the prism of law, robots, and society
Authors: Karnouskos Stamatis 
Published: May 2021

AbstractThe rapid advances in Artificial Intelligence and Robotics will have a profound impact on society as they will interfere with the people and their interactions. Intelligent autonomous robots, independent if they are humanoid/anthropomorphic or not, will have a physical presence, make autonomous decisions, and interact with all stakeholders in the society, in yet unforeseen manners. The symbiosis with such sophisticated robots may lead to a fundamental civilizational shift, with far-reaching effects as philosophical, legal, and societal questions on consciousness, citizenship, rights, and legal entity of robots are raised. The aim of this work is to understand the broad scope of potential issues pertaining to law and society through the investigation of the interplay of law, robots, and society via different angles such as law, social, economic, gender, and ethical perspectives. The results make it evident that in an era of symbiosis with intelligent autonomous robots, the law systems, as well as society, are not prepared for their prevalence. Therefore, it is now the time to start a multi-disciplinary stakeholder discussion and derive the necessary policies, frameworks, and roadmaps for the most eminent issues.
Developing pre-service primary teachers’ understanding of engineering through engineering habits of mind and engagement with engineers
Authors: Hanson Janet R. , Hardman Sally , Luke Sue , Lucas Bill 
Published: May 2021

AbstractThis paper explores how primary teachers might be prepared through their pre-service training to feel more confident to include engineering in their teaching. Prompted by concerns about young people’s lack of interest in STEM subjects and careers, engineering is gradually gaining visibility in the primary curriculum in several forms, particularly through integrated STEM programmes. However, the status of engineering relative to science, technology and mathematics remains contested in schools and engineering has low visibility in pre-service preparation programmes for primary teachers. Therefore, this case-study investigated how two strategies might give students learning to be primary technology, computing and science teachers greater confidence to introduce the concept of engineering into their teaching. By reframing engineering as engineering habits of mind and by giving students experience of engaging with practising engineers, the study found that it was possible to enhance primary trainee teachers’ understanding of the world of engineering and increase their confidence to introduce engineering habits of mind in lessons with primary children. The paper concludes with some implications for practice of this approach.
Congenital Athymia: Genetic Etiologies, Clinical Manifestations, Diagnosis, and Treatment
Authors: Collins Cathleen , Sharpe Emily , Silber Abigail , Kulke Sarah , Hsieh Elena W. Y. 
Published: May 2021

AbstractCongenital athymia is an ultra-rare disease characterized by the absence of a functioning thymus. It is associated with several genetic and syndromic disorders including FOXN1 deficiency, 22q11.2 deletion, CHARGE Syndrome (Coloboma, Heart defects, Atresia of the nasal choanae, Retardation of growth and development, Genitourinary anomalies, and Ear anomalies), and Complete DiGeorge Syndrome. Congenital athymia can result from defects in genes that impact thymic organ development such asFOXN1andPAX1or from genes that are involved in development of the entire midline region, such asTBX1within the 22q11.2 region,CHD7, andFOXI3. Patients with congenital athymia have profound immunodeficiency, increased susceptibility to infections, and frequently, autologous graft-versus-host disease (GVHD). Athymic patients often present with absent T cells but normal numbers of B cells and Natural Killer cells (T−B+NK+), similar to a phenotype of severe combined immunodeficiency (SCID); these patients may require additional steps to confirm the diagnosis if no known genetic cause of athymia is identified. However, distinguishing athymia from SCID is crucial, as treatments differ for these conditions. Cultured thymus tissue is being investigated as a treatment for congenital athymia. Here, we review what is known about the epidemiology, underlying etiologies, clinical manifestations, and treatments for congenital athymia.
When Methods Meet Motives: methodological pluralism in Social Work research
Authors: Ganzevles Martine , Andriessen Daan , Van Regenmortel Tine , van Weeghel Jaap 
Published: May 2021

AbstractIn Social Work research there is a strong debate on the distinctiveness and methodological quality, and how to address the dilemma of rigour and practice relevance. Given the nature of Social Work the field has developed a characteristic research culture that puts emphasis on giving voice to service users and disseminating research knowledge in practice, especially in a stream of so called practice-based research. However, there is no consensus on how to best contribute to the practice of Social Work through research and at the same time producing rigourous scientific outcomes, resulting in methodological pluralism. Studying the perceptions of Social Work researchers on their role, the aims and values of Social Work research and their research approach, provides insight into the methodological pluralism of Social Work research. Thirty-four professors specialising in practice-based Social Work research participated in a Q methodology study. Q methodology combines qualitative and quantitative methods. It helped reveal and describe divergent views as well as consensus. The analysis led to the identification of three differing viewpoints on Social Work research, which have been given the following denominators: The Substantiator, The Change Agent and The Enlightener. The viewpoints provide researchers in the field of Social Work with a framework in which they can position themselves in the methodological pluralism. Researchers state that the viewpoints are helpful in clarifying perspectives on good research, facilitate the discourse on methodological choices to further develop and strengthen Social Work research as a scientific discipline.