bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contactless Body Temperature Monitoring of In-Patient Department (IPD) Using 2.4 GHz Microwave Frequency via the Internet of Things (IoT) Network
Authors: Boonsong Wasana , Senajit Narongrit , Prasongchan Piya 
Published: April 2021

Abstract
Since the COVID-19 situation keeps going on started from 2019. Many solutions are to against the spreading of coronavirus disease. In this work, the contactless body temperature monitoring (CBTM) of the in-patient department (IPD) is applied using a 2.4 GHz microwave band via the Internet of Things (IoT) network. The specified infrared body temperature on the MLX90614 DCI used for the medical field was selected to embed the IoT-CBTM for IPD using the IoT platform because the MLX90614 is an accurate sensor that matches to use for medical promotion. In this study, the proposed embedded IoT-CBTM has tested the accuracy compared with the manual body temperature checking device under the Thai Industrial Standard Institute (TISI). The results found that the proposed wireless IoT-CBTM prototype achieved a reliability value of 48.7 %, nearly to the expected value, with positive correlations between devices at .322*. The information data will be transferred to store at cloud internet according to the time set every hour. The intelligent applications used for receiving data are Google Sheet and line application on smart devices.
Trajectory inference across multiple conditions with condiments: differential topology, progression, differentiation, and expression.
Authors: de Bézieux Hector Roux , Berge Koen Van den , Street Kelly , Dudoit Sandrine 
Published: April 2021

Abstract
In single-cell RNA-sequencing (scRNA-seq), gene expression is assessed individually for each cell, allowing the investigation of developmental processes, such as embryogenesis and cellular differentiation and regeneration, at unprecedented resolutions. In such dynamic biological systems, grouping cells into discrete groups is not reflective of the biology. Cellular states rather form a continuum, e.g., for the differentiation of stem cells into mature cell types. This process is often represented via a trajectory in a reduced-dimensional representation of the scRNA-seq dataset.

While many methods have been suggested for trajectory inference, it is often unclear how to handle multiple biological groups or conditions, e.g., inferring and comparing the differentiation trajectories of wild-type and knock-out stem cell populations.

In this manuscript, we present a method for the estimation and downstream interpretation of cell trajectories across multiple conditions. Our framework allows the interpretation of differences between conditions at the trajectory, cell population, and gene expression levels. We start by integrating datasets from multiple conditions into a single trajectory. By comparing the conditions along the trajectory’s path, we can detect large-scale changes, indicative of differential progression. We also demonstrate how to detect subtler changes by finding genes that exhibit different behaviors between these conditions along a differentiation path.
Irradiation stability and induced ferromagnetism in a nanocrystalline CoCrCuFeNi highly-concentrated alloy
Authors: Tunes Matheus Araujo , El-Atwani Osman , Greaves Graeme , Boldman Walker , Rack Philip , Schön Cláudio , Pogatscher Stefan , Maloy S. , Zhang Yanwen 
Published: April 2021

Abstract
In the field of radiation damage of crystalline solids -- where new highly-concentrated alloys (HCAs) are suitable candidate materials for next generation fission/fusion reactors -- outstanding radiation tolerance has been recently recorded. Despite the preliminarily reported extraordinary properties, the mechanisms of degradation, phase instabilities and decomposition of HCAs are still largely unexplored fields of research. Herein, we investigate the response of a nanocrystalline CoCrCuFeNi HCA to heavy ion irradiation in the temperature range from 293 to 773 K. The results led to the identification of two regimes of response to irradiation: (i) in which the alloy was observed to be tolerant under extreme irradiation conditions and (ii) in which the alloy is subject to matrix phase instabilities. The formation of FeCo monodomain nanoparticles under these conditions is also reported for the first time, which may have promising applications in new technological areas such as spintronics.
Child Maltreatment and associated Sociodemographic factors among Children affected by HIV/AIDS in Ghana: A Multi-Informant Perspective
Authors: Doku Paul Narh 
Published: April 2021

Abstract
Background: Child maltreatment and its consequences are considered a major public health concern among children because they can cause significant physical and psychological problems. Child maltreatment is widespread but often underestimated. Surprisingly, there is hardly any data on the frequency of child maltreatment in general and particularly on orphans and vulnerable children in low-income countries. Method: This study employed cross-sectional, quantitative survey that involved 291 children aged 10–17 years in Lower Manya Krobo District, Ghana and examined their exposure to and experience of child maltreatment. The survey also examined parents/caregivers’ exposure and perpetuation of child maltreatment. Results: Some form of maltreatment within the household was reported by approximately 90% of children, and it was significantly higher among orphans and vulnerable children (OVC) as compared with comparison children. Children living with HIV/AIDS-infected parents and orphans of any type reported higher exposure to domestic violence and experienced significantly more neglect, psychological and physical abuse than the comparison children. Conclusion: The results of this survey demonstrate that maltreatment among children affected by HIV/AIDS are not rare, and that the dysfunction family conditions that they find themselves bear systemic risks for maltreatment. It is important that culturally appropriate and evidence-based interventions are implemented to address the maltreatment.
Clean Development Mechanism (CDM)-based Development of Grid-connected Rice Husk-fuelled Bio-power Plants in Mekong Delta, Vietnam
Authors: Song Nguyen Van , Ha Thai Van , Thuan Tran Duc , Hanh Nguyen Van , Tien Dinh Van , Tiep Nguyen Cong , Phuong Nguyen Thi Minh , Phuong Pham Thi Lan , Uan Tran Ba , Tu Phan Anh 
Published: April 2021

Abstract
The research is designed for developing the pilot small-scale clean development mechanism bundled project activities in Vietnam electricity/ energy sector. Its overall purpose is to assess the potential of rice husk - fuelled bio-power development projects in Mekong delta. Based on estimating the electricity potential of a bundle of rice husk-fuelled bio-power development projects in Mekong delta with the capacity of 11 MW per project, assessing their CO2 emission reductions (CERs) and CER credits, calculating and comparing their financial indices (NPV, B/C, IRR) in two cases: W/O CDM and W/CDM, the research expects to establish a rice husk energy balance flowchart for the whole Mekong delta in the year 2021 and recommend policies to use for bio-power generation the unused rice husk that is dumped and discharged from local paddy milling centers into rivers and canals, as well as, to put forward a safe and environmentally friendly solution to minimize thoroughly the current serious pollution of rivers and canals in Mekong delta with the increasing unused rice husk quantity in the context is where the sea level rise phenomenon is the strongest in the world .
Observation of miniaturized bound states in the continuum
with ultra-high quality factors
Authors: Chen Zihao , Yin Xuefan , Jin Jicheng , Zheng Zhao , Zhang Zixuan , Wang Feifan , He Li , zhen Bo , Peng Chao 
Published: April 2021

Abstract
Light trapping is a constant pursuit in photonics because of its importance in science and technology. Many mechanisms have been explored, including the use of mirrors made of materials or structures that forbid outgoing waves, and bound states in the continuum that are mirror-less but based on topology. Here we report a compound method, combing mirrors and bound states in the continuum in an optimized way, to achieve a class of on-chip optical cavities that have high quality factors and small modal volumes. Specifically, light is trapped in the transverse direction by the photonic band gap of the lateral hetero-structure and confined in the vertical direction by the constellation of multiple bound states in the continuum. As a result, unlike most bound states in the continuum found in photonic crystal slabs that are de-localized Bloch modes, we achieve light-trapping in all three dimensions and experimentally demonstrate quality factors as high as Q = 1.09×106 and modal volumes as low as V = 3.56 μm3 in the telecommunication regime. We further prove the robustness of our method through the statistical study of multiple fabricated devices. Our work provides a new method of light trapping, which can find potential applications in photonic integration, nonlinear optics and quantum computing.
Ectopic expression of finger millet calmodulin confers drought and salinity tolerance in Arabidopsis thaliana
Authors: Jamra Gautam , Agrawal Aparna , Singh Nidhi , Sanyal Sibaji K. , Kumar Anil , Pandey Girdhar Kumar 
Published: April 2021

Abstract
Drought and salinity are major environmental stresses which affect crop productivity and therefore are major hindrance in feeding growing population world-wide. Calcium (Ca2+) signalling plays a crucial role during the plant's response to these stress stimuli. Calmodulin (CaM), a crucial Ca2+sensor, is involved in transducing the signal downstream in various physiological, developmental and stress responses by modulating a plethora of target proteins. The role of CaM has been well established in the model plant Arabidopsis thaliana for regulating various developmental processes, stress signalling and ion transport. In the current study, we investigate the CaM of Eleusine coracana (common name finger millet, known especially for its drought tolerance and superior Ca2+ content). In-silico analysis showed that Eleucine calmodulin (EcCaM) has greater similarity to rice CaM as compared to Arabidopsis CaM due to the presence of highly conserved four EF-hand domains. To decipher the in planta function of EcCaM, we have adopted the gain-of-function approach by generating the 35S::EcCaM over-expression transgenic in Arabidopsis. Overexpression of EcCaM in Arabidopsis makes the plant tolerant to polyethylene glycol (PEG) induced drought and salt stress (NaCl) as demonstrated by post-germination based phenotypic assay, ion leakage, MDA and proline estimation, ROS detection under stressed and normal conditions. Moreover, EcCaM-overexpression leads to hypersensitivity towards exogenously applied ABA at the seed germination stage. These findings reveal that EcCaM mediates tolerance to drought and salinity stress. Also, our results indicate that EcCaM is involved in modulating ABA signalling. Summarizing our results, we report for the first time that EcCaM is involved in modulating plants response to stress and this information can be used for the generation of future-ready crops that can tolerate a wide range of abiotic stresses.
Impacts of Global Warming on Meiyu-Baiu Extreme Rainfall and Associated Mid-Latitude Synoptic-Scale Systems as Inferred From 20km AGCM Simulations
Authors: So Ka Wai , Tam Chi-Yung , Lau Ngar-Cheung 
Published: April 2021

Abstract
The impacts of global warming on Meiyu-Baiu extreme rainfall and the associated mid-latitude synoptic-scale weather systems over the Eastern China (EC) and the Baiu rainband (Bu) regions in East Asia have been examined, based on simulations from the 20-km Meteorological Research Institute atmospheric general circulation model (MRI-AGCM3.2S). This model was demonstrated to give realistic Asian extreme rainfall, when compared with data from the Tropical Rainfall Measuring Mission (TRMM). Here we used a novel wave-selection algorithm based on the 300hPa wind, in order to identify upper-level propagating wave signals in conjunction with the occurrence of extreme precipitation in either EC or Bu. The same algorithm was applied for both the present (1979-2003) and future (2075-2099) climate simulations from the AGCM, so as to infer the impacts of global warming on the behavior of these systems. Results show robust decrease of intensity of systems influencing both Bu and EC in the future warmer climate. Their corresponding low-to-mid level circulation, as revealed by vertical velocity, temperature advection and sea-level pressure composites, was also found to be weakened. This is likely related to changes in the background circulation in future over the East Asian mid-latitude zone, such as the widespread increment of the seasonal mean static stability at 500 hPa. However, the wave-associated precipitation over these regions was enhanced in the future climate simulations. This can be attributed to more strong intensity rainfall, which increases as the background temperature in these regions warms, largely following the Clausius-Clapeyron relation. Therefore, changes of wave-related extreme precipitation in EC and Bu are mainly controlled by the thermodynamic effect; the latter appears to be much stronger than the potential impacts due to the slight weakening of these weather systems.
Phosphorylation dependent mitochondrial translocation of Nr4a3 provokes cardiomyocyte death
Authors: Zhang Hang , Xie Hongyang , Hu Jian , Zhu Zhenbin , Zhuang Lingfang , Chen Qiujing , Shen Weifeng , Sano Motoaki , Fukuda Keiichi , Gutiérrez-Chico Juan Luis , Lu Lin , Zhang Ruiyan , Yan Xiaoxiang 
Published: April 2021

Abstract
Immediate early gene-nuclear receptor subfamily 4, group A, member 3 (Nr4a3) is implicated in a variety of cellular processes. However, its role and underlying mechanisms in ischemia reperfusion (IR) remain unknown. Here, we show that Nr4a3 expression is upregulated in the heart after IR and that cardiac specific Nr4a3 deficiency protects against myocardial ischemic injury and improves cardiac function. The overexpression of Nr4a3 in both neonatal and adult mouse hearts is sufficient to cause left ventricular dilation and contractile dysfunction without additional ischemic stress. Mechanistically, ischemia or hypoxia triggers Nr4a3 phosphorylation and translocation from the nucleus to mitochondria, where it interacts with and promotes Bnip3 integration into the mitochondrial membrane. This integration leads to mitochondrial permeability transition pore (mPTP) opening and decreased mitochondrial permeability transition pore (ΔΨm), which causes cardiomyocyte apoptotic and necrotic death. Our findings describe an Nr4a3-Bnip3 mitochondrial pathway underlying cell death.
Effectiveness and tolerability of radiotherapy for patients with indolent non-Hodgkin's lymphoma - a monocenter analysis
Authors: Hadi Indrawati , Schummer Anne , Dreyling Martin , Eze Chukwuka , Bodensohn Raphael , Roengvoraphoj Olarn , Belka Claus , Li Minglun 
Published: April 2021

Abstract
Purpose To analyze the effectiveness and toxicities of radiotherapy in indolent non-Hodgkin's lymphoma (iNHL) patients treated in our institution. Material and Methods Patients with iNHL treated with radiotherapy between 1999 and 2016 were included. The primary endpoint was progression-free survival (PFS). Secondary endpoints were local control (LC), overall survival (OS) and toxicities. PFS, LC, and OS were analyzed using Kaplan-Meier method. Log-rank test was used to investigate the differences between subgroups. Cox proportional hazard model was used for univariate continuous analysis.Results Seventy-five patients were identified in our institutional database between 1999 and 2016. Fifty-eight (77.3%) had stage I after Ann-Arbor and 17 patients (22.7%) had stage II. The median follow-up was 87 months (95%-CI: 72 – 102 months). Median single dose per fraction was 2.0 Gy (range, 1.5 – 2 Gy) and median total dose was 30.6 Gy (range, 16 – 45 Gy). Radiotherapy was performed in 2D (n = 10; 13.3%), 3D (n = 63; 84.0%) and VMAT (n = 2; 2.7%) techniques, respectively. The median PFS was 14.0 years (95%-CI: 8.3 – 19.7 years). The estimated PFS after 5 and 10 years were 73.0% and 65.5% in Kaplan-Meier analysis, respectively. The 5- and 10- year LC were 94.9% and 92.3%, respectively. The 5- and 10-year OS were 88.6% and 73.9%. In univariate analyses of PFS, younger patients (≤ 60 years old) had significantly superior PFS to those older than 60 years old (5-year PFS 81.9% vs. 65.1%, p= 0.021). Dose escalation >36.0Gy had no prognostic influence in term of PFS (p= 0.543). Extranodal involvement, stage and histology had no prognostic impact on PFS. Depending on the site of lymphomas, the most common acute side effects were: dermatitis CTCAE °I - II (8.0%), xerostomia CTC °I (8.0%), cataract CTC °I (12.0%) and dry eyes CTC °I - II (14.6%). No adverse event CTC° III was reported. Most acute side effects recovered at 3 to 6 months after radiotherapy except for CTC °I cataract and xerostomia. Conclusion Local Radiotherapy was highly effective for treatment of early stage iNHL with no serious side effects in our cohort. The most acute CTCAE °I – II side effects recovered 3 to 6 months later. Technique advances seem to have further improved effectiveness and tolerability of radiotherapy. Trial registration: Local ethics committee of Ludwig-Maximilian-University (LMU) Munich approved this retrospective analysis on the May 7th, 2019 (Nr. 19-137).
Seasonal Variation in Space Use and Territoriality in an Invasive Large Mammal (Sus Scrofa)
Authors: Schlichting Peter E. , Boughton Raoul K. , Anderson Wes , Wight Bethany , VerCauteren Kurt C. , Miller Ryan S. , Lewis Jesse S. 
Published: April 2021

Abstract
An individual’s spatial behavior is shaped by social and environmental factors and provides critical information about population processes to inform conservation and management actions. Heterogeneity in spatial overlap among conspecifics can be evaluated using estimates of home ranges and core areas and used to understand factors influencing space use and territoriality. To understand and test predictions about spatial behavior in an invasive large mammal, the wild pig (Sus scrofa), we examined variation in space use between sexes and seasons. We predicted that if animals were territorial that there would be a reduction in space-use overlap when comparing overlap of home ranges (HR-HR), to home ranges and core areas (HR-CA), and in-turn to core areas (CA-CA). Home ranges and core areas were estimated for 54 wild pigs at Buck Island Ranch, FL from GPS telemetry data. Overlap indices were calculated to estimate the strength (space-use overlap) and number of potential interactions within three wet seasons (June-October) and two dry seasons (December-April). Across all seasons, males exhibited larger home ranges compared to females (M = 10.36±0.79 km² (±SE), F = 3.21±0.16 km²) and interacted with a greater number of individuals than females. Home range size and strength of interactions did not vary between wet and dry seasons. Consistent with our predictions, wild pigs appeared to exhibit territorial behavior, where strength of overlap decreased when comparing HR-HR to HR-CA and HR-CA to CA-CA. Strength of overlap varied by sex, which was lowest between females, intermediate between females and males, and greatest between males. Our framework can be used to understand patterns of space use and territoriality in populations, which has important implications in understanding population processes and how pathogens and parasites might spread within and among populations.
Trends in Arctic seasonal and extreme precipitation in recent decades
Authors: Yu Lejiang , Zhong Shiyuan 
Published: April 2021

Abstract
Daily precipitation data from the European Centre for Medium-Range Weather Forecasts (ERA-Interim) from 1979 to 2016 are analyzed to determine the trends in seasonal and extreme precipitation across the pan-Arctic and estimate the contributions to the trends from the dynamic (e.g. changes in circulation patterns) and thermodynamic processes (e.g., sea ice melt – water vapor feedback) and their interactions. The trends in the seasonal total precipitation are generally consistent with the trends in the occurrence of seasonal extreme precipitation. Although the trends vary considerably in direction and magnitude across the pan-Arctic and the seasons, more regions experience a statistically significant positive trend than negative trend, particularly in autumn and winter seasons and over areas of the Arctic Ocean and the northern North Atlantic. Statistically significant negative trends are mostly found in areas of northern Eurasian and North America. The thermodynamic processes account for more than 85% of the total trends, with the rest of the trends explained by the dynamic processes (e.g., changes in circulation patterns) and the interaction between dynamic and thermodynamic processes.
Impact of Cymbopogon Flexuosus (Poaceae) Essential Oil and Primary Components on the Eclosion and Larval Development of Aedes Aegypti
Authors: Castillo-Morales Ruth Mariela , Serrano Sugey Ortiz , Villamizar Adriana Lisseth Rodríguez , Méndez-Sánchez Stelia Carolina , Duque Jonny Edward 
Published: April 2021

Abstract
The current study describes the effects of sub-lethal concentrations and constituent compounds (citral and geranyl acetate) of Cymbopogon flexuosus essential oil (EO) on the development of Aedes aegypti. We treated eggs with 6, 18, and 30 mg.L-1 and larvae with 3 and 6 mg.L-1 EO concentrations. Citral and geranyl acetate were evaluated at 18, 30, and 42 mg.L-1 and compared to the commercial growth inhibitors (diflubenzuron and methoprene). We measured larval head diameter, siphon length, and body length. Finally, we examined concentrations of moult hormone (MH) and juvenile hormone III (JH III) using high-performance liquid chromatography coupled to mass spectrometry. The EO decreased egg hatching at all concentrations and altered molting among larval instars and between larvae and pupae, with an increase in the length (3 mg.L-1: 6 ± 0.0 mm; 6 mg.L-1: 6 ± 0.7 mm) and head width (3 mg.L-1: 0.8 ± 0 mm; 6 mg.L-1: 0.8 ± 0.0 mm) compared with the control group. We did not detect chromatographic signals of MH and JH III in larvae treated with C. flexuosus EO or their major compounds. The sub-lethal concentrations C. flexuosus EO caused a similar effect to diflubenzuron, decreasing hormone concentration, extending the larval period, and death.