bluuebunny/crossref_metadata_2025_split huggingface dataset:
On-admission Serum High-Sensitivity C-Reactive Protein Level Independently Predicts In-Hospital Mortality and Adverse Cardiovascular Events in ST-elevation Acute Myocardial Infarction
Authors: Hartopo Anggoro Budi , Sukmasari Indah , Inggriani Maria Patricia , Rikl Thomas , Hayon Stefi Geovani Valentin , Rosqie Royhan , Puspitawati Ira 
Published: December 2021

Background: Inflammatory biomarkers are associated with adverse cardiovascular events during ST-elevation acute myocardial infarction (STEMI). We aimed to investigate the role of inflammatory biomarkers, high-sensitivity C-reactive protein (hs-CRP), and soluble ST-2 (sST2), for prediction of adverse cardiovascular events in STEMI. Methods: This was a prospective cohort study that consecutively enrolled patients with STEMI. Subjects were observed during hospitalization until discharge or fatal events happened. Adverse cardiovascular event was a compilation of cardiac mortality, acute heart failure, cardiogenic shock, reinfarction, and malignant ventricular arrhythmia. Blood samples were withdrawn on admission and inflammatory biomarkers (hs-CRP and sST2) were measured. The receiver operator characteristics curve and multivariable analysis were performed to determine which inflammatory biomarkers predict in-hospital adverse cardiovascular events and mortality. Result: Of 166 subjects, the in-hospital adverse cardiovascular events occurred in 41 subjects (24.6%) and mortality occurred in 16 subjects (9.6%). Subjects with in-hospital adverse cardiovascular events and mortality had a significantly higher hs-CRP level, but comparable sST2 level than subjects without events. The hs-CRP level was the most precise biomarkers to predict in-hospital adverse cardiovascular events (hs-CRP cut-off ≥2.75 mg/L) and mortality (hs-CRP cut-off ≥7 mg/L). Multivariable analysis indicated hs-CRP ≥2.75 mg/L as an independent predictor for in-hospital adverse cardiovascular events (adjusted odds ratio [OR]: 2.79, 95% confidence interval [CI]: 1.05-7.39, P = .039) and hs-CRP ≥7 mg/L for mortality (adjusted OR: 5.45, 95% CI: 1.13-26.18, P = .034) in STEMI. Conclusion: On admission, hs-CRP level independently predicted in-hospital adverse cardiovascular events, at cut-off level ≥2.75 mg/L, and mortality, at cut-off level ≥7 mg/L, in STEMI patients.
Surrounding Objects Detection and Tracking for Autonomous Driving Using LiDAR and Radar Fusion
Authors: Liu Ze , Cai Yingfeng , Wang Hai , Chen Long 
Published: December 2021

AbstractRadar and LiDAR are two environmental sensors commonly used in autonomous vehicles, Lidars are accurate in determining objects’ positions but significantly less accurate as Radars on measuring their velocities. However, Radars relative to Lidars are more accurate on measuring objects velocities but less accurate on determining their positions as they have a lower spatial resolution. In order to compensate for the low detection accuracy, incomplete target attributes and poor environmental adaptability of single sensors such as Radar and LiDAR, in this paper, an effective method for high-precision detection and tracking of surrounding targets of autonomous vehicles. By employing the Unscented Kalman Filter, Radar and LiDAR information is effectively fused to achieve high-precision detection of the position and speed information of targets around the autonomous vehicle. Finally, the real vehicle test under various driving environment scenarios is carried out. The experimental results show that the proposed sensor fusion method can effectively detect and track the vehicle peripheral targets with high accuracy. Compared with a single sensor, it has obvious advantages and can improve the intelligence level of autonomous cars.
Optimal Design for Anti-Skid Control of Electric Vehicles by Fuzzy Approach
Authors: Li Chenming , Zhao Han , Huang Kang , Chen Ye-Hwa 
Published: December 2021

AbstractIn this paper, a new fuzzy approach is applied to optimal design of the anti-skid control for electric vehicles. The anti-skid control is used to maintain the wheel speed when there are uncertainties. The control is able to provide an appropriate torque for wheels when the vehicle is about to skid. The friction coefficient and the moments of inertia of wheels and motor are considered as uncertain parameters. These nonlinear, bounded and time-varying uncertainties are described by fuzzy set theory. The control is deterministic and is not based on IF-THEN fuzzy rules. Then, the optimal design for this fuzzy system and control cost is proposed by fuzzy information. In this way, the uniform boundedness and uniform ultimate boundedness are guaranteed and the average fuzzy performance is minimized. Numerical simulations show that the control can prevent vehicle skidding with the minimum control cost under uncertainties.
Investigation on the Flow Behavior of Side Channel Pumps Based on Vortex Identification
Authors: Zhang Fan , Appiah Desmond , Chen Ke , Yuan Shouqi , Adu-Poku Kofi Asamoah , Zhu Lufeng 
Published: December 2021

AbstractThe momentum flow exchange between the impeller and side channel produces highly turbulent flows in side channel pumps. The turbulent flows feature complex patterns of vortex structures that are partly responsible for the dissipation of energy losses and unsteady pressure pulsations. The concept of turbulent flows in side channel pumps requires a reliable vortex identification criterion to capture and predict the effects of the vortex structures on the performance. For this reason, the current study presents the application of the new Ω-criterion to a side channel pump model in comparison with other traditional methods such as Q and λ2 criteria. The 3D flow fields of the pump were obtained through unsteady Reynolds-averaged Navier-Stokes (RANS) simulations. Comparative studies showed that the Ω-criterion identifies the vortex of different intensities with a standard threshold, Ω=0.52. The Q and λ2 criteria required different thresholds to capture vortex of different intensities thus leads to subjective errors. Comparing the Ω-criterion intensity on different planes with the entropy losses and pressure pulsation, the longitudinal vortex plays an important role in the momentum exchange development which increases the head performance of the pump. However, the rate of exchange is impeded by the axial and radial vortices restricted in the impeller. Therefore, the impeller generates the highest entropy loss and pressure pulsation intensities which lower the output efficiency. Finally, the findings provide a fundamental background to the morphology of the vortex structures in the turbulent flows which can be dependent upon for efficiency improvement of side channel pumps.
The mechanical properties and thermal conductivity of bamboo with freeze–thaw treatment
Authors: Wu Jieyu , Wang Xianke , Fei Benhua , Xu Xiang , Lian Caiping , Chen Hong 
Published: December 2021

AbstractThe aim of this research was to investigate the effect of freeze–thaw treatment on bamboo with different initial moisture content (water-saturated, air-dried and oven-dried). Bamboo (Phyllostachys pubescens) were treated with two freeze treatments and its microstructure, chemical composition, mechanical properties and thermal conductivity were characterized by field emission scanning electron microscopy (FE-SEM), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), mechanical testing machine and thermal conductivity tester, respectively. The results showed that the freeze–thaw treatment had little influence on the microstructure of bamboo, the chemical composition content and the cellulose crystalline structure of bamboo were also not altered. The crystallinity index was found to increase with the increase of initial moisture content. The bending strength and elastic modulus of the treated bamboo increased, the extent of the increase was dependent on the initial moisture content and the freezing temperature. The thermal conductivity of the treated bamboo increased remarkably, which might be possibly determined by the cellulose crystallinity, moisture content, and density of bamboo.
Fyn kinase regulates dopaminergic neuronal apoptosis in animal and cell models of high glucose (HG) treatment
Authors: Tan Changhong , Liu Xi , Zhang Xiaoshuai , Peng Wuxue , Wang Hui , Zhou Wen , Jiang Jin , Mo Lijuan , Chen Yangmei , Chen Lifen 
Published: December 2021

Abstract
Background
High glucose (HG) is linked to dopaminergic neuron loss and related Parkinson’s disease (PD), but the mechanism is unclear.

Results
Rats and differentiated SH-SY5Y cells were used to investigate the effect of HG on dopaminergic neuronal apoptotic death. We found that a 40-day HG diet elevated cleaved caspase 3 levels and activated Fyn and mTOR/S6K signaling in the substantia nigra of rats. In vitro, 6 days of HG treatment activated Fyn, enhanced binding between Fyn and mTOR, activated mTOR/S6K signaling, and induced neuronal apoptotic death. The proapoptotic effect of HG was rescued by either the Fyn inhibitor PP1 or the mTOR inhibitor rapamycin. PP1 inhibited mTOR/S6K signaling, but rapamycin was unable to modulate Fyn activation.

Conclusions
HG induces dopaminergic neuronal apoptotic death via the Fyn/mTOR/S6K pathway.
Genetic association tests in family samples for multi-category phenotypes
Authors: Wang Shuai , Meigs James B. , Dupuis Josée 
Published: December 2021

Abstract
Background
Advancements in statistical methods and sequencing technology have led to numerous novel discoveries in human genetics in the past two decades. Among phenotypes of interest, most attention has been given to studying genetic associations with continuous or binary traits. Efficient statistical methods have been proposed and are available for both types of traits under different study designs. However, for multinomial categorical traits in related samples, there is a lack of efficient statistical methods and software.

Results
We propose an efficient score test to analyze a multinomial trait in family samples, in the context of genome-wide association/sequencing studies. An alternative Wald statistic is also proposed. We also extend the methodology to be applicable to ordinal traits. We performed extensive simulation studies to evaluate the type-I error of the score test, Wald test compared to the multinomial logistic regression for unrelated samples, under different allele frequency and study designs. We also evaluate the power of these methods. Results show that both the score and Wald tests have a well-controlled type-I error rate, but the multinomial logistic regression has an inflated type-I error rate when applied to family samples. We illustrated the application of the score test with an application to the Framingham Heart Study to uncover genetic variants associated with diabesity, a multi-category phenotype.

Conclusion
Both proposed tests have correct type-I error rate and similar power. However, because the Wald statistics rely on computer-intensive estimation, it is less efficient than the score test in terms of applications to large-scale genetic association studies. We provide computer implementation for both multinomial and ordinal traits.
Weighted gene coexpression correlation network analysis reveals a potential molecular regulatory mechanism of anthocyanin accumulation under different storage temperatures in ‘Friar’ plum
Authors: Li Xueling , Cheng Yudou , Wang Meng , Cui Sujuan , Guan Junfeng 
Published: December 2021

Abstract
Background
Flesh is prone to accumulate more anthocyanin in postharvest ‘Friar’ plum (Prunus salicina Lindl.) fruit stored at an intermediate temperature. However, little is known about the molecular mechanism of anthocyanin accumulation regulated by storage temperature in postharvest plum fruit.

Results
To reveal the potential molecular regulation mechanism of anthocyanin accumulation in postharvest ‘Friar’ plum fruit stored at different temperatures (0 °C, 10 °C and 25 °C), the fruit quality, metabolite profile and transcriptome of its flesh were investigated. Compared to the plum fruit stored at 0 °C and 25 °C, the fruit stored at 10 °C showed lower fruit firmness after 14 days and reduced the soluble solids content after 21 days of storage. The metabolite analysis indicated that the fruit stored at 10 °C had higher contents of anthocyanins (pelargonidin-3-O-glucoside, cyanidin-3-O-glucoside, cyanidin-3-O-rutinoside and quercetin-3-O-rutinose), quercetin and sucrose in the flesh. According to the results of weighted gene coexpression correlation network analysis (WGCNA), the turquoise module was positively correlated with the content of anthocyanin components, and flavanone 3-hydroxylase (F3H) and chalcone synthase (CHS) were considered hub genes. Moreover, MYB family transcription factor APL (APL), MYB10 transcription factor (MYB10), ethylene-responsive transcription factor WIN1 (WIN1), basic leucine zipper 43-like (bZIP43) and transcription factor bHLH111-like isoform X2 (bHLH111) were closely related to these hub genes. Further qRT–PCR analysis verified that these transcription factors were specifically more highly expressed in plum flesh stored at 10 °C, and their expression profiles were significantly positively correlated with the structural genes of anthocyanin synthesis as well as the content of anthocyanin components. In addition, the sucrose biosynthesis-associated gene sucrose synthase (SS) was upregulated at 10 °C, which was also closely related to the anthocyanin content of plum fruit stored at 10 °C.

Conclusions
The present results suggest that the transcription factors APL, MYB10, WIN1, bZIP43 and bHLH111 may participate in the accumulation of anthocyanin in ‘Friar’ plum flesh during intermediate storage temperatures by regulating the expression of anthocyanin biosynthetic structural genes. In addition, the SS gene may play a role in anthocyanin accumulation in plum flesh by regulating sucrose biosynthesis.
Morphometric assessment of spleen dimensions and its determinants among individuals living in Arba Minch town, southern Ethiopia
Authors: Demissie Solomon , Mergu Prasad , Hailu Tadiwos , Abebe Getachew , Warsa Mengistu , Fikadu Teshale 
Published: December 2021

Abstract
Introduction
The spleen is a vital lymphoid soft organ that demands constant attention from the clinical point of view. It is a multi-dimensional organ that enlarges in its all dimensions during some disease condition. The detection of the spleen by palpation is not an indicator of an enlarged spleen because normal spleen may be palpable. Therefore, this study aimed to assess the morphometry of spleen dimensions and its determinants among individuals living in Arba Minch town by sonographic examinations.

Methods and materials
Community-based cross-sectional study was conducted in Arba Minch town from February 1 to March 30, 2020. Seven hundred and eight study participants were selected using a multi-stage systematic random sampling technique. Data were checked for completeness, edited, coded and entered into Epi-Data version 3.1 and exported to STATA software version 16 for analysis.

Result
The mean splenic length, width, thickness and volume were 10.24 cm, 4.79 cm, 3.93 cm, and 109.34 cm3, respectively. The mean spleen length, width, thickness and volumes among males were 10.64 cm, 4.92 cm, 4.05 cm and 119.81 cm3 and among females were 9.75 cm, 4.63 cm, 3.78 cm and 96.50 cm3 respectively. As age increased by one year the mean spleen length, width, thickness and volume was decreased by 0.032 cm, 0.018 cm 0.004 cm and 0.012 cm respectively. As height increased by 1 cm the mean spleen width and volume were increased by 0.096 cm and 0.052 cm respectively. As we go from male to female the mean spleen length decreased by 0.294 cm.

Conclusion
The spleen dimensions were higher in males than females. Splenic length was determined by age & sex, the spleen width was determined by age & height, the spleen volume was determined by age & height and the spleen thickness was determined by age.
METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children
Authors: Zhuo Zhenjian , Hua Rui-Xi , Zhang Huizhu , Lin Huiran , Fu Wen , Zhu Jinhong , Cheng Jiwen , Zhang Jiao , Li Suhong , Zhou Haixia , Xia Huimin , Liu Guochang , Jia Wei , He Jing 
Published: December 2021

Abstract
Background
Wilms tumor is a highly heritable malignancy. Aberrant METTL14, a critical component of N6-methyladenosine (m6A) methyltransferase, is involved in carcinogenesis. The association between genetic variants in the METTL14 gene and Wilms tumor susceptibility remains to be fully elucidated. We aimed to assess whether variants within this gene are implicated in Wilms tumor susceptibility.

Methods
A total of 403 patients and 1198 controls were analyzed. METTL14 genotypes were assessed by TaqMan genotyping assay.

Result
Among the five SNPs analyzed, rs1064034 T > A and rs298982 G > A exhibited a significant association with decreased susceptibility to Wilms tumor. Moreover, the joint analysis revealed that the combination of five protective genotypes exerted significantly more protective effects against Wilms tumor than 0–4 protective genotypes with an OR of 0.69. The stratified analysis further identified the protective effect of rs1064034 T > A, rs298982 G > A, and combined five protective genotypes in specific subgroups. The above significant associations were further validated by haplotype analysis and false-positive report probability analysis. Preliminary mechanism exploration indicated that rs1064034 T > A and rs298982 G > A are correlated with the expression and splicing event of their surrounding genes.

Conclusions
Collectively, our results suggest that METTL14 gene SNPs may be genetic modifiers for the development of Wilms tumor.
The identification of gene signatures in patients with extranodal NK/T-cell lymphoma from a pair of twins
Authors: Wang Yang , Tan Huaicheng , Yu Ting , Ma Xuelei , Chen Xiaoxuan , Jing Fangqi , Zou Liqun , Shi Huashan 
Published: December 2021

Abstract
Background
There is no unified treatment standard for patients with extranodal NK/T-cell lymphoma (ENKTL). Cancer neoantigens are the result of somatic mutations and cancer-specific. Increased number of somatic mutations are associated with anti-cancer effects. Screening out ENKTL-specific neoantigens on the surface of cancer cells relies on the understanding of ENKTL mutation patterns. Hence, it is imperative to identify ENKTL-specific genes for ENKTL diagnosis, the discovery of tumor-specific neoantigens and the development of novel therapeutic strategies. We investigated the gene signatures of ENKTL patients.

Methods
We collected the peripheral blood of a pair of twins for sequencing to identify unique variant genes. One of the twins is diagnosed with ENKTL. Seventy samples were analyzed by Robust Multi-array Analysis (RMA). Two methods (elastic net and Support Vector Machine-Recursive Feature Elimination) were used to select unique genes. Next, we performed functional enrichment analysis and pathway enrichment analysis. Then, we conducted single-sample gene set enrichment analysis of immune infiltration and validated the expression of the screened markers with limma packages.

Results
We screened out 126 unique variant genes. Among them, 11 unique genes were selected by the combination of elastic net and Support Vector Machine-Recursive Feature Elimination. Subsequently, GO and KEGG analysis indicated the biological function of identified unique genes. GSEA indicated five immunity-related pathways with high signature scores. In patients with ENKTL and the group with high signature scores, a proportion of functional immune cells are all of great infiltration. We finally found that CDC27, ZNF141, FCGR2C and NES were four significantly differential genes in ENKTL patients. ZNF141, FCGR2C and NES were upregulated in patients with ENKTL, while CDC27 was significantly downregulated.

Conclusion
We identified four ENKTL markers (ZNF141, FCGR2C, NES and CDC27) in patients with extranodal NK/T-cell lymphoma.
Predictors for HIV testing among Chinese workers in infrastructure construction enterprises in Kenya
Authors: Zhou Wenjuan , Deng Wenyu , Luo Junfei , Bai Yin , He Zeyi , Wang Honghong 
Published: December 2021

AbstractBackgroundThere are increasing Chinese migrants in sub-Saharan Africa currently. Most of them are engaged in infrastructure construction. Research has shown that they stay at particular risk of HIV and are recommended for HIV testing. However, their HIV testing behavior, and its relevant factors, have not been researched among them by now. This study describes the recent HIV testing behavior and relevant factors among Chinese migrant workers in Kenya.MethodsA cross-sectional survey was conducted among 110 male Chinese workers from six different Chinese infrastructure construction enterprises in Kenya. Furthermore, a two-stage cluster random sampling method was used to select participants. We used a questionnaire that included HIV testing history, demographic characteristics, and putative multilevel facilitators of HIV testing. Logistic regression was used to explore the predictors of recent HIV testing behavior among Chinese migrant workers in Kenya.ResultOf the 110 participants, 30 (27.27%) were tested for HIV in the recent year. All participants were male, and the majority were married (73.2%). The mean age was 37.49 years (SD = 9.73; range: 23 to 63), and a considerable proportion refused to answer questions about transactional sexual behaviors in the last year. Most were able to obtain HIV-related information (91.8%) and were exposed to HIV-related information in the last year (68.2%), but only 47.6% had sufficient HIV knowledge. Nearly one-fifth of them believed that selling sex and paying for sex is acceptable. Multiple logistic regression analysis indicated that participants who could accept the ‘pay for sex’ (OR: 2.74; 95% CI: 1.02, 7.36) and exposed to HIV related information (OR: 4.75; 95% CI: 1.29, 17.44) were more likely to test for HIV in the recent 1 year.ConclusionHigher current HIV test rates were associated with a more open sexual attitude towards paying for sex and being exposed to HIV-related information in the last year among Chinese workers in Kenya. More specific attention to HIV should be attached to this population to increase the rate of HIV testing among them.