bluuebunny/crossref_metadata_2025_split huggingface dataset:
Better be prepared: the spectrum of neuropsychiatric impairment among Libyan war victims transferred to Germany for trauma rehabilitation
Authors: Dootz Felix , von Stackelberg Otto-Magnus , Abaya Joan , Jacobi Christian , Mohs Christoph , Craemer Eva Maria , Rangger Christoph , Meyding-Lamadé Uta , Lamadé Eva Kathrin 
Published: July 2021

Abstract
Background
The current Libyan civil war has originated many casualties, imposing medical challenges. War injuries are complex, requiring specialized knowledge and interdisciplinary assessment for adequate patient and intercultural management.

Methods
This retrospective study analyzed records of 78 Libyan patients admitted from July 2016 to November 2017 to neurological and trauma surgical departments of Krankenhaus Nordwest, Frankfurt, Germany. Issues of system preparation of the hospital, demographics, injury patterns and therapies were analyzed. The chi-squared test was used to analyze differences in injury patterns in explosion and gunshot injuries.

Results
Seventy-seven of seventy-eight patients were male (mean age 30.6 years). The patients received primary and secondary treatment in Tunisia (n = 39), Libya (n = 36) and Turkey (n = 23). Forty-eight patients had gunshot injuries, 37 explosion injuries, 11 both. Preparation for management of injuries included hygienic and isolation protocols, organization of interpreters and intercultural training. Patients presented with a broad variety of neurological, psychiatric and trauma surgical injuries. Fifty-six patients had sensory, 47 motor deficits. Nine reported headache, 5 vertigo, 13 visual impairment, 28 psychiatric symptoms. Eighteen patients had central nervous damage, 50 peripheral nervous damage. Central nervous damage was significantly more common in gunshot than explosion injuries (p = 0.015). Peripheral nervous damage was more common in explosion than gunshot injuries (p < 0.1). Fifty-one patients had polytrauma and 49 suffered from fractures. Therapy included surgical interventions (n = 56) and physiotherapy. Structured rehabilitation programs were often indicated.

Conclusion
Specialized knowledge about war injuries and their management including hospital preparation and planning regarding infrastructure may be required anytime. Injuries include a broad variety of neurological, psychiatric and trauma surgical injuries. Therefore, an interdisciplinary approach is crucial.
A development cycle for automated self-exploration of robot behaviors
Authors: Roehr Thomas M. , Harnack Daniel , Wöhrle Hendrik , Wiebe Felix , Schilling Moritz , Lima Oscar , Langosz Malte , Kumar Shivesh , Straube Sirko , Kirchner Frank 
Published: July 2021

AbstractIn this paper we introduce Q-Rock, a development cycle for the automated self-exploration and qualification of robot behaviors. WithQ-Rock, we suggest a novel, integrative approach to automate robot development processes.Q-Rockcombines several machine learning and reasoning techniques to deal with the increasing complexity in the design of robotic systems. TheQ-Rockdevelopment cycle consists of three complementary processes: (1) automated exploration of capabilities that a given robotic hardware provides, (2) classification and semantic annotation of these capabilities to generate more complex behaviors, and (3) mapping between application requirements and available behaviors. These processes are based on a graph-based representation of a robot’s structure, including hardware and software components. A central, scalable knowledge base enables collaboration of robot designers including mechanical, electrical and systems engineers, software developers and machine learning experts. In this paper we formalizeQ-Rock’s integrative development cycle and highlight its benefits with a proof-of-concept implementation and a use case demonstration.
Current advances on mechanisms and treatment of post-stroke seizures
Authors: Fu Yujiao , Feng Li , Xiao Bo 
Published: July 2021

AbstractCerebrovascular diseases are among the most common causes of seizures in adults, especially in the elderly. With the increased incidence of stroke, the population with post-stroke seizures has grown, leading to the increased awareness of this disorder in the society. The most common seizure type after stroke is the focal seizure with or without evolution into bilateral convulsive seizures. Post-stroke seizures impair the quality of life, as well as the physical and mental health of those patients. Currently, the pathological and physical processes of post-stroke seizures are not quite clear yet. In this review, we summarize current advances in the pathogenesis, risk factors, and therapeutic targets of post-stroke seizures.
The new ichnotaxon Eubrontes nobitai ichnosp. nov. and other saurischian tracks from the Lower Cretaceous of Sichuan Province and a review of Chinese Eubrontes-type tracks
Authors: Xing Li-Da , Lockley Martin G. , Klein Hendrik , Zhang Li-Jun , Romilio Anthony , Scott Persons W. , Peng Guang-Zhao , Ye Yong , Wang Miao-Yan 
Published: July 2021

AbstractThe Jiaguan Formation and the underlying Feitianshan Formation (Lower Cretaceous) in Sichuan Province yield multiple saurischian (theropod–sauropod) dominated ichnofaunas. To date, a moderate diversity of six theropod ichnogenera has been reported, but none of these have been identified at the ichnospecies level. Thus, many morphotypes have common “generic” labels such as Grallator, Eubrontes, cf. Eubrontes or even “Eubrontes-Megalosauripus” morphotype. These morphotypes are generally more typical of the Jurassic, whereas other more distinctive theropod tracks (Minisauripus and Velociraptorichnus) are restricted to the Cretaceous. The new ichnospecies Eubrontes nobitai ichnosp nov. is distinguished from Jurassic morphotypes based on a very well-preserved trackway and represents the first-named Eubrontes ichnospecies from the Cretaceous of Asia.
Sustainable plant-based diets promote rainbow trout gut microbiota richness and do not alter resistance to bacterial infection
Authors: Pérez-Pascual David , Pérez-Cobas Ana Elena , Rigaudeau Dimitri , Rochat Tatiana , Bernardet Jean-François , Skiba-Cassy Sandrine , Marchand Yann , Duchaud Eric , Ghigo Jean-Marc 
Published: July 2021

Abstract
Background
Farmed fish food with reduced fish-derived products are gaining growing interest due to the ecological impact of fish-derived protein utilization and the necessity to increase aquaculture sustainability. Although different terrestrial plant proteins could replace fishmeal proteins, their use is associated with adverse effects. Here, we investigated how diets composed of terrestrial vegetal sources supplemented with proteins originating from insect, yeast or terrestrial animal by-products affect rainbow trout (Onchorynchus mykiss) gut microbiota composition, growth performance and resistance to bacterial infection by the fish pathogen Flavobacterium psychrophilum responsible for frequent outbreaks in aquaculture settings.

Results
We showed that the tested regimes significantly increased gut bacterial richness compared to full vegetal or commercial-like diets, and that vegetal diet supplemented with insect and yeast proteins improves growth performance compared to full vegetal diet without altering rainbow trout susceptibility to F. psychrophilum infection.

Conclusion
Our results demonstrate that the use of insect and yeast protein complements to vegetal fish feeds maintain microbiota functions, growth performance and fish health, therefore identifying promising alternative diets to improve aquaculture’s sustainability.
An efficient algorithm of the unified stochastic particle Bhatnagar-Gross-Krook method for the simulation of multi-scale gas flows
Authors: Fei Fei , Ma Yang , Wu Jie , Zhang Jun 
Published: July 2021

AbstractThe unified stochastic particle method based on the Bhatnagar-Gross-Krook model (USP-BGK) has been proposed recently to overcome the low accuracy and efficiency of the traditional stochastic particle methods, such as the direct simulation Monte Carlo (DSMC) method, for the simulation of multi-scale gas flows. However, running with extra virtual particles and space interpolation, the previous USP-BGK method cannot be directly transplanted into the existing DSMC codes. In this work, the implementation of USP-BGK is simplified using new temporal evolution and spatial reconstruction schemes. As a result, the present algorithm of the USP-BGK method is similar to the DSMC method and can be implemented efficiently based on any existing DSMC codes just by modifying the collision module.
Do bicortical diaphyseal array pins create the risk of periprosthetic fracture in robotic-assisted knee arthroplasties?
Authors: Yun Andrew G. , Qutami Marilena , Pasko Kory B. Dylan 
Published: July 2021

Abstract
Background
Optical array placement for robotic-assisted knee replacement introduces the rare, but real risk of periprosthetic fracture. The purpose of this retrospective study was to review the incidence of fracture with the conventional technique of bicortical diaphyseal pin placement. We also evaluated a modified method of unicortical periarticular pin placement to mitigate this risk.

Methods
We reviewed 2603 knee arthroplasties that were performed between June 2017 and December 2019. The conventional bicortical diaphyseal technique was used in 1571 knees (bicortical diaphyseal group) and the unicortical periarticular technique was used in 1032 knees (unicortical periarticular group).

Results
A more than 1-year follow-up revealed that 3 femoral shaft fractures (0.19%) occurred in the bicortical diaphyseal group and no fracture took place in the unicortical periarticular group. There was no array loosening in either group.

Conclusions
The modified unicortical periarticular pin placement is a reliable technique for computer-navigated and robotic-assisted knee arthroplasties. It may be associated with a lower incidence of postoperative femoral shaft fractures, compared to conventional bicortical diaphyseal pinning.
Safety and efficacy of elagolix (with and without add-back therapy) for the treatment of heavy menstrual bleeding associated with uterine leiomyomas: a systematic review and meta-analysis
Authors: Ali Mustafa , Hira Aruna Kumari , Jawaid Haris , Zakaria Faiza , Somjee Zehra 
Published: July 2021

Abstract
Background
Heavy menstrual bleeding (HMB) is a common clinical finding in patients with uterine leiomyomas that can negatively impact their quality of life. Recently, a novel oral GnRH-antagonist (elagolix) has emerged as a possible therapeutic agent for this ailment. Herein data was pooled from clinical trials assessing the safety and efficacy of elagolix with and without add-back therapy.

Main text
PubMed and Cochrane library were systematically searched for RCTs that measured the efficacy and safety of elagolix for the treatment of uterine fibroid-associated HMB. All safety and efficacy endpoints were compared between elagolix-alone, elagolix w/add-back therapy, and placebo. The primary efficacy endpoint was defined as the number of women who achieved menstrual blood loss (MBL) < 80 ml and a reduction in MBL from baseline of > 50% at the end of treatment. Secondary outcomes assessed included change in hemoglobin levels, incidence suppression of bleeding and amenorrhea, and the incidence of adverse events. The random effects model was used to pool data, and heterogeneity was assessed using I2.
Our search identified 4 clinical trials meeting our PICO criteria, with a total of 916 patients. Analysis of the primary outcome revealed that elagolix-alone was the most effective treatment compared to both placebo (LOR = 3.47, CI = 3.03–3.91, p = 0.000, I2 = 0.0%) and add-back therapy (LOR = 0.64, CI = 0.12–1.16, p = 0.016, I2 = 43.1%). Furthermore, both elagolix groups (irrespective of add-back therapy) observed a significant improvement in post-treatment hemoglobin levels as compared to the placebo group (elagolix-alone vs PBO: LOR = 1.44, CI = 0.66–2.22, I2 = 66.0%, p = 0.000; elagolix-w/add-back therapy vs PBO: LOR = 1.22, CI = 0.78–1.66, I2 = 0.0%, p = 0.000). Concerning safety, while elagolix without add-back therapy had the highest overall incidence of adverse effects (elagolix-alone vs placebo LOR = 0.84, CI = 0.48–1.20, I2 = 7.8%, p = 0.000; elagolix-alone vs elagolix-w/add-back LOR = 0.68, CI = 0.09–1.26, p = 0.024, I2 = 64.6%), the incidence of serious (life threatening) adverse events between all 3 treatment groups was not statistically different. The inclusion of add-back therapy with elagolix made the treatment noticeably safer (elagolix-w/add-back vs placebo: LOR = 0.19, CI = − 0.10 to 0.48, I2 = 0.0%, p = 0.194) without seriously compromising its efficacy.

Conclusion
High-quality evidence from 4 trials suggests that elagolix is an effective treatment for leiomyoma-associated HMB, with a marked improvement in all efficacy endpoints. Furthermore, the inclusion of add-back therapy in the treatment regimen should be considered as it mitigates the hypoestrogenic effects of elagolix.
Adapting coordinated specialty care in the post-COVID-19 era: study protocol for an integrative mixed-methods study
Authors: Patel Sapana R. , Bello Iruma , Cabassa Leopoldo J. , Nossel Ilana R. , Wall Melanie M. , Montague Elaina , Rahim Reanne , Mathai Chacku M. , Dixon Lisa B. 
Published: July 2021

Abstract
Background
Coordinated Specialty Care (CSC) programs provide evidence-based services for young people with a recent onset of a psychotic disorder. OnTrackNY is a nationally recognized model of CSC treatment in New York state. In 2019, OnTrackNY was awarded a hub within the Early Psychosis Intervention Network (EPINET) to advance its learning health care system (LHS). The OnTrackNY network is comprised of 23 CSC teams across New York state. OnTrack Central, an intermediary organization, provides training and implementation support to OnTrackNY teams. OnTrack Central coordinates a centralized data collection protocol for quality improvement and evaluation of program fidelity and a mechanism to support practice based-research. OnTrackNY sites’ breadth coupled with OnTrack Central oversight provides an opportunity to examine the impacts of the COVID-19 crisis in New York State, and supplementary funding was awarded to the OnTrackNY EPINET hub in 2021 for that purpose.

Methods
This project will examine the implications of modifications to service delivery within the OnTrackNY LHS during and after the COVID-19 crisis. We will use the Framework for Reporting Adaptations and Modification-Enhanced (FRAME) to classify systematically, code, and analyze modifications to CSC services and ascertain their impact. We will utilize integrative mixed methods. Qualitative interviews with multi-level stakeholders (program participants, families, providers, team leaders, agency leaders, trainers (OnTrack Central), and decision-makers at the state and local levels) will be used to understand the process of making decisions, information about modifications to CSC services, and their impact. Analysis of OnTrackNY program data will facilitate examining trends in team staffing and functioning, and participant service utilization and outcomes. Study findings will be summarized in a CSC Model Adaptation Guide, which will identify modifications as fidelity consistent or not, and their impact on service utilization and care outcomes.

Discussion
A CSC Model Adaptation Guide will inform CSC programs, and the state and local mental health authorities to which they are accountable, regarding modifications to CSC services and the impact of these changes on care process, and participant service utilization and outcomes. The guide will also inform the development of tailored technical assistance that CSC programs may need within OnTrackNY, the EPINET network, and CSC programs nationally.

Trial registration
NCT04021719, July 16th, 2019.
Pharmacokinetic predictions and docking studies of substituted aryl amine-based triazolopyrimidine designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH)
Authors: Ibrahim Zakari Ya’u , Uzairu Adamu , Shallangwa Gideon Adamu , Abechi Stephen Eyije 
Published: July 2021

Abstract
Background
The sixteen (16) designed data set of substituted aryl amine-based triazolopyrimidine were docked against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) employing Molegro Virtual Docker (MVD) software and their pharmacokinetic property determined through SwissADME predictor.

Results
The docking studies shows compound D16, 5-((6-methoxy-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amino)benzo[b]thiophen-4-ol to be the most interactive and stable derivative (re-rank score = − 114.205 kcal/mol) resulting from the hydrophobic as well as hydrogen interactions. The hydrogen interaction produced one hydrogen bond with the active residues LEU359 (H∙∙H∙∙O) at a bond distances of 2.2874 Å. All the designed derivatives were found to pass the Lipinski rule of five tests, supporting the drug-likeliness of the designed compounds.

Conclusion
The ADME analysis revealed a perfect concurrence with the Lipinski Ro5, where the derivatives were found to possess good pharmacokinetic properties such as molar refractivity (MR), number of rotatable bonds (nRotb), log of skin permeability (log Kp), blood-brain barrier (BBB). These results could a deciding factor for the optimization of novel antimalarial compounds.
Cerebral ischemic stroke and different approaches for treatment of stroke
Authors: Girnar Ghanashyam Arun , Mahajan Hitendra Shaligram 
Published: July 2021

Abstract
Background
Cerebral ischemia can be considered a lethal disease as it is a leading cause of death worldwide with no prompt line of treatment. The factors which make this disease more fatal are failure of drugs while crossing BBB, very low availability of the drug in the brain, inefficiency of drug molecule in the clinical studies, limited availability of clinical data, lack of awareness about this disease, and many more.

Main body
This review focuses on reasons and mechanisms of stroke, classification of brain ischemia; it also reveals the current scenario of stroke in India. Very few drugs are effective for the treatment of stroke. This compilation furnishes conventional and recent treatments of stroke along with their hurdles like the gap between preclinical and clinical studies. This review also suggests effective routes of administration of drugs for the treatment of brain ischemia specifically nose-to-brain route and effectiveness of different dosage forms precisely nanoformulations, as the most effective dosage form.

Conclusion
By following different guidelines and treatments, the risk of brain ischemia can be minimized as well as some advanced techniques for the treatment of this disease proving their efficiency. One of the important aspects in the success of the treatment for this disease is the route of administration of the drug. Among all routes, intranasal drug delivery presents a potential approach and is supposed to be the next-generation therapy for brain disorders. The nose-to-brain route is very effective, and it shows some promising results in case of stroke treatment. The strategy is still under investigation despite various successful lab-scale studies; there are numerous challenges to reach the product in the market. Research is going on to get a better understanding of this strategy. We believe that detailed studies to resolve pitfalls will lead to the successful development of an intranasal formulation for the management of ischemic brain injury such as stroke.
An emotions-informed approach for digital documentation of rural heritage landscapes: Baojiatun, a traditional tunpu village in Guizhou, China
Authors: Nancarrow Jane-Heloise , Yang Chen , Yang Jing 
Published: July 2021

AbstractThe application of digital technologies has greatly improved the efficiency of cultural heritage documentation and the diversity of heritage information. Yet the adequate incorporation of cultural, intangible, sensory or experimental elements of local heritage in the process of digital documentation, and the deepening of local community engagement, remain important issues in cultural heritage research. This paper examines the heritage landscape of tunpu people within the context of digital conservation efforts in China and the emergence of emotions studies as an evaluative tool. Using a range of data from the Ming-era village of Baojiatun in Guizhou Province, this paper tests an exploratory emotions-based approach and methodology, revealing shifting interpersonal relationships, experiential and praxiological engagement with the landscape, and emotional registers within tunpu culture and heritage management. The analysis articulates distinctive asset of emotional value at various scales and suggests that such approaches, applied within digital documentation contexts, can help researchers to identify multi-level heritage landscape values and their carriers. This methodology can provide more complete and dynamic inventories to guide digital survey and representation; and the emotions-based approach also supports the integration of disparate heritage aspects in a holistic understanding of the living landscape. Finally, the incorporation of community participation in the process of digital survey breaks down boundaries between experts and communities and leads to more culturally appropriate heritage records and representations.
Full-scale test of precast prestressed concrete double-tee girder for rural bridges
Authors: Nguyen Dinh Hung , Vu Hong Nghiep , Nguyen Thac Quang 
Published: July 2021

AbstractIncreasing the number of small and medium-sized bridges is a need to improve accessibility in rural areas of the Mekong River Delta of Vietnam. Many types of bridge structures can be the suitable selection for rural bridges, on which the overall load of the operating truck is about 100kN. An objective of this paper is to propose a double-tee (DT) girder with the span length varying from 12 m to 15 m for the rural bridge types B and C in the Vietnamese standard. New concrete aggregate using crushed sand and fly ash for the DT girders is also examined to solve the scarcity of natural sand and environmental problem from industrial waste. A full-scale DT girder with a span length of 12 m is tested to confirm the capacity of the proposed design. Result finds out that the concrete sand, which the natural sand is replaced by 90% of the crushed sand and 10% of the fly ash by weight, could be well applied for the proposed DT girders. Another finding is a linear elastic uncracked response of the tested DT girder under loads of a rural vehicle and concrete blocks of 306kN. Therefore, the proposed DT girders are suggested to the rural bridges.