bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe Hemolytic Anemia and Acute Renal Failure After Mitral Valve Repair Associated With Non-endothelialization of Artificial Chordae Tendinae: Case Report
Authors: Li Jing , Duan Qun-Jun 
Published: September 2021

Abstract
Background: Mechanical hemolytic anemia and acute renal failure are rare complication sof mitral valve repair.Case presentation: We report a unique case of severe hemolytic anemia and severe acute renal failure after mitral valve repair using artificial chordae tendinae. Conservative therapy including plasmapheresis and blood transfusion was not effective. The major cause of the mechanical hemolysis was mild mitral regurgitation originating from the centre of the valve and striking the annuloplasty ring. The hemolytic anemia resolved gradually after the replacement of mitral valve. The new artificial chordae tendinae was found to be completely non-endothelialized in the surgery. Non-endothelialization of artificial chordae tendinae may also play a role in the genesis of mechanical anemia. Conclusions: The major cause of the mechanical hemolysis was mild mitral regurgitation originating from the centre of the valve and striking the annuloplasty ring. Non-endothelialization of foreign materials might be another mechanism of hemolysis after mitral repair.
Synthesis of thiophenylazolyl pyrrolylsulfamoyl acetamides as potential antimicrobial agents
Authors: Rajeswari Tankam , Sankar Panga Siva , Babu Kayathi Narendra , Padmaja Adivireddy , Padmavathi Venkatapuram 
Published: September 2021

Abstract
A variety of thiophenylazolyl pyrrolylsulfamoyl acetamides were prepared by the reaction of azolylsulfamoyl acetate with pyrrolylamine in the presence of sodium methoxide in methanol under ultrasonication. Chloro, nitro and dinitro substituted thiophenylthiazolyl pyrrolylsulfamoyl acetamides (9d, 9e, 9f) and dinitro substituted thiophenylimidazolyl pyrrolylsulfamoyl acetamide (10f) exhibited potential antibacterial activity against B. subtilis. The compound 9f also displayed prominent antibacterial activity against S. aureus. The compounds 9f, chloro and nitro substituted thiophenylimidazolyl pyrrolylsulfamoyl acetamide (10d, 10e) and 10f exhibited prominent antifungal activity against A.niger.
Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment
Authors: Ahmed Muhammad Adeel , Anwar Muhammad Faraz , Ahmed Khalid , Aftab Marziya , Nazim Fizza , Bari Muhammad Furqan , Mustafa Mohammed , Vohra Fahim , Alrahlah Ali , Mughal Muhammad Nouman , Abidi Syed Hani 
Published: September 2021

Abstract
Background

Matrix metalloproteinases (MMPs) catalyzes the degradation of the extracellular matrix components and have a major role in many physiological processes including wound healing. In the current study, we examined the correlation of baseline MMPs 1, 2, 7, and 9 expressions with periapical wound healing after surgical endodontic treatment.
Methods

27 patients aged between 15–57 years presenting with chronic apical periodontitis or chronic apical abscess of an anterior tooth with previously attempted or failed root canal treatment were included in this study. During surgical endodontic treatment, tissue from the periapical lesion sample was collected and used for gross histopathological analysis as well as mRNA expression analysis of MMPs 1, 2, 7, and 9. Patients were recalled for follow-up after 6 and 12 months to evaluate the healing status both clinically and radiographically and healing was correlated with baseline MMP expression.
Results

Out of 27 patients, healing was observed in 15 patients at the end of 6 months, and patients after 12 months. Six patients showed no healing even after 12 months. Analysis of baseline MMP 1, 2, 7, and 9 expression levels with healing status showed the mean relative expression of MMP2 and MMP9 to be considerably increased in the non-healing group as compared to the healing group.
Conclusion

Overexpression of MMP2 and MMP9 may be considered as a potential prognostic biomarker for periapical wound healing after surgical endodontic treatment. However, further studies are desirable to establish its precise relationship with periapical wound healing.
Effects of post oak Quercus Stellata and Smooth Brome Bromus Inermis Competition on Water Uptake and Root Partitioning of Eastern Redcedar Juniperus Virginiana
Authors: Hamati Samia , Medeiros Juliana S. , Ward David 
Published: September 2021

Abstract
Water availability may alter species competitive interactions, resulting in different outcomes as plants compete for available water. Eastern redcedar Juniperus virginiana (hereafter ERC) will likely continue to encroach into new habitats, which will affect soil and water budgets. We designed a greenhouse experiment to investigate changes in water uptake and rooting depths of two-year old ERC saplings in the presence of an invasive grass (Bromus inermis) and a native tree (Quercus stellata). We measured soil moisture content over two growing seasons. When grown together, ERC took up water from the deeper layers (21–40 cm) whereas B. inermis used water from the top layers of the soil (0–20 cm). Similarly, when ERC grew with Q. stellata, ERC took up water from the deeper layers and Q. stellata used water mostly from the top layers. This root partitioning can allow the co-existence of ERC, grasses, and other trees, which can facilitate ERC encroachment into grasslands and woodlands. However, when the three species grew together, we found root overlap between the ERC and Q. stellata. This overlap can affect ERC establishment and encroachment in habitats where grasses and trees co-occur. A major factor that affected ERC performance was higher mortality in treatments with B. inermis than in the ERC-alone or with Q. stellata. This indicates that competition with grasses is a major factor affecting ERC sapling establishment.
Biochemical and molecular mechanisms associated with the effect of Phoenix dactylifera seeds on cyclophosphamide-induced hepato-renal toxicities in mice
Authors: El-Naggar Sabry Ali , Basyouny Mohamed A. , Alqarni Mohammed , Haidyrah Ahmed S. , Amin Samer Ezat , Elwan Mona , Barnawi Ibrahim Omar , El-Said Karim Samy 
Published: September 2021

Abstract
Cyclophosphamide (CTX) causes severe side effects. Phoenix dactylifera L. showed biomedical values. This study aims to address the biochemical and molecular mechanisms of Phoenix dactylifera seeds extract (PDSE) effects on CTX-induced hepato-renal toxicities in mice. Forty male albino mice were divided into four groups: Gp 1 was served as a negative control, Gp2 was injected intraperitoneally (i.p) with PDSE (200 mg/kg) for 30 consecutive days. Gp3 was injected with CTX single dose (200 mg/kg) and Gp4 was injected with CTX then injected with PDSE. Hematological, biochemical, histopathological alterations, and gene expression for pro-inflammatory cytokine were assessed. GC-MS analysis showed the highest percentages of the peak areas were by Ethyl iso-allocholate, 1-Heptatriacotanol, and 9-12-15-Octadecatrienoic acid 2-3-dihydroxypropyl ester. Treatment with PDSE post-CTX-injection ameliorated the hematological, biochemical, and histological alterations by up-regulating the antioxidant biomarkers and downregulating tumor growth factor beta-1 (TGFβ-1), nuclear factor Kappa-beta (NFκ-β), cyclooxygenase-1 (COX-1) genes.
A specific Upregulated lncRNA in Colorectal Cancer Promotes Cancer Progression by Modulating miR-185-5p/CCND2 Axis
Authors: Li Junshu , Ji Yanhong , Chen Na , Wang Huiling , Fang Chao , Yin Xiaonan , Jiang Zhiyuan , Dong Zhexu , Zhu Dan , Jiang Ruiyi , Fu Jiamei , Zhang Hantao , Shi Gang , Cheng Lin , Su Xiaolan , Dai Lei , Deng Hongxin 
Published: September 2021

Abstract
BackgroundAdenomatous polyposis coli (APC) gene mutations were found in most colorectal cancer patients and functioned as an important inducer of tumorigenesis. Long non-coding RNA (lncRNA) plays a crucial role in the pathogenesis of various diseases, including colorectal cancer (CRC). Here we investigated the role of SURC which is specific upregulated in CRC progression. MethodsBased on the previous microarray results, weighted correlation network analysis (WGCNA) and lncRNA-mRNA co-expression network analysis were used to identify a lncRNA (SURC) and found it was specific up-regulated in CRC patients by qPCR and FISH staining. Chromatin immunoprecipitation (ChIP) assay was used to demonstrate the regulatory effect and mechanism of APC mutation on SURC expression. The effects of SURC on proliferation and cell cycle were determined by in vitro and in vivo experiments. Chromatin Isolation by RNA Purification (CHIRP) and luciferase reporter assay were carried out to illustrate the interaction between SURC, miR-185-5p and CCND2.ResultsWe found that SURC was specific up-regulated in CRC, but not in other solid tumor, when compared with normal adjacent tissues. High expression of SURC correlates with poorer disease-free survival and overall survival of CRC patients. Mutated APC protein resulted in stabilization of β-catenin in CRC, which promotes the transcription of SURC via binding to its promoter. Knockdown of SURC impaired CRC cell proliferation, colony formation and CRC tumor growth. Mechanistically, after transcription, SURC was transferred to cytoplasm and inhibits miR-185-5p expression via binding to miR-185-5p and inhibiting the synthesis of miR-185-5p from pri-miR-185-5p, which results in CCND2 expression.Conclusion﻿Collectively, these results indicated that SURC promoted CRC tumor growth via interacting with miR-185-5p and regulating the activity of miR-185-5p/CCND2 axis which would be a novel diagnosis and prognosis prediction target for CRC.
New Resilience Instrument for Family Caregivers in Cancer: A Multidimensional Item Response Theory Analysis
Authors: LIANG MU ZI , TANG YING , CHEN PENG , LIANG JIAN , SUN ZHE , HU GUANG YUN , YU YUAN LIANG , Ye Zeng-Jie 
Published: September 2021

Abstract
Objective: Resilience instruments specific to family caregivers (FCs) in cancer are limited. This study was designed to validate the 10-item Resilience Scale Specific to Cancer (RS-SC-10) in FCs using multidimensional item response theory (MIRT) analysis.Methods: 382 FCs were enrolled from Be Resilient to Cancer Program (BRCP) and administered with RS-SC-10 and 36-item Short Form Health Survey (SF-36). MIRT was performed to evaluate item parameters while Generalized Additive Model (GAM) and Latent Profile Analysis (LPA) were performed to test the non-linear relationship between resilience (RS-SC-10) and Quality of Life (QoL, SF-36).Results: RS-SC-10 retained 10 items with high multidimensional discrimination, monotonous thresholds and its original two-factor structure (Generic and Shift-Persist). Four latent resilience subgroups were identified and a non-linear dose-response pattern between resilience and QoL was confirmed (per-SD increase OR= 1.62, 95%CI, 1.16-2.13, p=0.0019).Conclusion: RS-SC-10 is a brief and suitable resilience instrument for FCs in cancer. The resilience screening of patients and FCs can be performed simultaneously in clinical practice.
Did States With More Social Capital Pre-pandemic Offer Mental Health Protection During the COVID-19 Pandemic? A Cross-sectional View
Authors: Dauner Kim Nichols , Wilmot Neil A. 
Published: September 2021

Abstract
Background: Mental health has declined during the COVID-19 pandemic, and social capital, as a determinant of health, may serve to buffer those declines. Methods: Building from this, we assessed whether pre-pandemic social capital, which included indicators of social trust, civic participation, and the presence of mask mandates affected pandemic mental health, measured as the percent of the population experiencing symptoms of depression and anxiety at the state level. Results: Generalized social trust and state mask mandates were significantly associated with lower levels of depression and anxiety. Conversely, states with greater civic engagement prior to the pandemic experienced more anxiety and depression.Conclusions: Findings suggest that existing social capital, particularly social trust, may protect against anxiety and depression and contribute to community resilience during times of adversity. States should invest in policies and programs that increase social trust.
High expression of AFFs is related to prognosis of acute myeloid leukemia
Authors: chen xi , Yan Qin , Qin Xiang , Liu Jing , Zeng Yan , Long Sili , Liu Wenjun 
Published: September 2021

Abstract
BackgroundAFF family genes (AFF1, AFF2, AFF3, AFF4, AFFs) are closely related to the occurrence, development and prognosis of a variety of tumors, but the relationship between AFFs and acute myeloid leukemia (AML) is still unclear. This study aims to explore the relationship between AFFs and the prognosis of AML by bioinformatics and real time quantitative PCR. MethodsAnalyze the expression of AFFs in AML patients and AML cell lines through ONCOMINE, GEPIA, EMBL-EBI, and CCLE databases, explore the prognostic value of AFFs in AML through the TCGA database,explore Co-expression and functional enrichment analysis of AFFs through the Linkedomics, DAVID and KOBAS database.We collected peripheral blood samples of 24 cases of AML (non-M3 subtype) and 8 cases of benign individuals, and detected the mRNA expression level of AFFs by real-time fluorescent quantitative PCR (clinical data comes from hospitalized medical records). ResultsThe results of multiple data sets showed that the mRNA transcription level of AFF1, AFF2, AFF3, and AFF4 in AML was significantly higher than that of normal people. Among them, the high expression of AFF1, AFF2, and AFF3 was statistically significant (p<0.05). Our clinical data showed that the mRNA expression levels of AFF1 and AFF2 in AML patients were higher than those in the control group (p<0.05). The high expression of AFF1 was significantly negatively correlated with overall survival (OS) (p<0.05), the high expression of AFF2 was significantly positively correlated with OS (p<0.05), and the high expression of AFF3 was not correlated with OS (p>0.05). ConclusionAFF1 and AFF2 are highly expressed in AML. The high expression of AFF1 is significantly negatively correlated with OS, and the high expression of AFF2 is significantly positively correlated with OS, which may become a new target for treatment.
The Prevalence and Pattern of Cannabis Use Among Patients Attending a Methadone Treatment Clinic in Nairobi, Kenya
Authors: Ngarachu Elizabeth Wambui , Kiburi Sarah Kanana , Owiti Frederick R. , Kangethe Rachel 
Published: September 2021

Abstract
Background: Cannabis use during methadone treatment may negatively impact treatment outcomes. The aim of this study was to determine the prevalence and pattern of cannabis use among patients attending a methadone treatment clinic in Nairobi, Kenya. Methods: This was a retrospective study of 874 patients on methadone therapy at a methadone maintenance treatment clinic in Nairobi, Kenya from December 2014 to November 2018. Data on sociodemographic characteristics and drug use patterns based on urine drug screens was collected from patient files. Data was analyzed using Statistical Package for the Social Sciences (SPSS) for windows version 23.0. Results: Prevalence of cannabis use was 85.8% (95% CI, 83.3 – 88.0) at baseline and 62.7% (95% CI, 59.5 – 65.8) during follow up. A pattern of polysubstance use was observed where opioids, cannabis and benzodiazepines were the most commonly used drugs. The mean age of the patients was 35.3 (SD 9.0) years with majority being male, unemployed (76%), had primary level of education (51.4%) and divorced or separated (48.5%). Cannabis use was associated with dropping out of treatment (p=0.001) and university education was associated with reduced risk for cannabis use OR=0.1 (95% CI, 0.02-0.8, p=0.031). Conclusion: Cannabis use is prevalent among patients attending a methadone treatment clinic in Kenya and is associated with dropping out of treatment. There is a need for targeted interventions to address the problem of cannabis use during methadone maintenance treatment in Nairobi, Kenya.
Defining ICD-10 surrogate variables to estimate the modified frailty index: a Delphi-based approach
Authors: Subramaniam Ashwin , Ueno Ryo , Tiruvoipati Ravindranath , Darvall Jai , Srika Velandai , Bailey Michael , Pilcher David , Bellomo Rinaldo 
Published: September 2021

Abstract
BackgroundThere are currently no validated globally and freely available tools to estimate the modified frailty index (mFI). The widely available and non-proprietary International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) coding could be used as a surrogate for the mFI. We aimed to establish an appropriate set of the ICD-10 codes for comorbidities to be used to estimate the eleven-variable mFI.MethodsA three-stage, web-based, Delphi consensus-building process among a panel of intensivists and geriatricians using iterative rounds of an online survey, was conducted between March and July 2021. The consensus was set a priori at 75% overall agreement. Additionally, we assessed if survey responses differed between intensivists and geriatricians. Finally, we ascertained the level of agreement.ResultsA total of 21 clinicians participated in all 3 Delphi surveys. Most (86%, 18/21) had more than 5-years’ experience as specialists. The agreement proportionately increased with every Delphi survey. After the third survey, the panel had reached 75% consensus in 87.5% (112/128) of ICD-10 codes. The initially included 128 ICD-10 variables were narrowed down to 54 at the end of the 3 surveys. The inter-rater agreements between intensivists and geriatricians were moderate for surveys 1 and 3 (κ = 0.728, κ = 0.780) respectively, and strong for survey 2 (κ = 0.811).ConclusionsThis quantitative Delphi survey of a panel of experienced intensivists and geriatricians achieved consensus for appropriate ICD-10 codes to estimate the mFI. Future studies should focus on validating the mFI estimated from these ICD-10 codes.
Person Recognition Using Soft Biometric
Authors: Sriniva Lavanya 
Published: September 2021

Abstract
Global security concerns raised the multiplication of video surveillance devices. Intelligent systems identify the person captured at the different cameras, angles, views, background, and wearing different accessories. Gait is measured at a distance without human cooperation. In this work, gait recognition is increased by concatenating semantic features with traditional features. Combining features are dimensionally reduced and classified using classifiers. This method motivates in future to increase the gait recognition with less false positive detection.
A Review on Carbon Nanotubes (CNT): Structure, Synthesis, Purification and Properties for Modern day Applications
Authors: Taib Nur-Azzah Afifah Binti , Rahman Md. Rezaur , Matin Mohammed Mahbubul , Uddin Jamal , Bakri Muhammad Khusairy Bin , Khan Afrasyab 
Published: September 2021

Abstract
Carbon nanotubes (CNTs), composed of graphene/graphite sheets, have been used since the 1990s and become one of the most important materials owing to its massive applications in energy, environmental and life sciences. In general, there are two types of known CNTs such as single-walled CNTs (SWCNTs) and multi-walled CNTs (MWCNTs). They have broader and novel fields of application in the fabric and textile industries, wastewater treatment, energy storage, and also as structural reinforcement materials. CNTs are reported to synthesize by arc discharge, laser ablation and chemical vapor deposition (CVD) methods where CVD technique is found to be the most versatile and largely used method. In all the methods synthesized CNTs contain various degrees of impurities which are purified by oxidation treatment, ultra-sonication, magnetic purification, etc. CNTs have wide range of industrial applications due to their remarkable mechanical, thermal, electrical, chemical and biological properties. In this review, medical and biomedical applications of CNTs and CNTs-based composites are specially focused due to their significant applications in these fields along with their structure, classification, preparation and related properties. Besides, CNTs’ toxicity and biosafety, especially on the human body, are also discussed in this review article.
The Central Role of Peers Facilitators in the Empowerment of Breast Cancer Patients: A Qualitative Study
Authors: LOGNOS Béatrice , Boulze-Launay isabelle , Million Elodie , Bourrel Gérard , Amouyal Michel , Gocko Xavier , Clary Bernard , Ninot Grégory , Oude-Engberink Agnès 
Published: September 2021

Abstract
Background In 2020, the number of new cancer cases was estimated at 20 490 862 worldwide up from 18.1 million in 2018 and 14.1 million in 2012. Since the 2000s, cancer treatments have significantly improved, allowing either a cure or control of the disease. Patients share their experience of the disease and use supportive care solutions through involvement in patient associations and online forums. All the associations were built on the principle of “peer support,” which is based on mutual aid between people who suffer or have suffered from the same somatic or psychological illness or had the same life experience.This experiential knowledge can be explored to understand the role of peers and associations in the appropriation of their cancer Methods: A qualitative phenomenological study was undertaken through semi-structured interviews with 12 participants. Interviews were audio-recorded, transcribed verbatim, then analyzed by means of triangulation up to the point of theoretical saturation, by a semio-pragmatic method. Results: Four categories emerged: (1) “Transforms a painful experience into a positive one. It mobilizes the human values of sharing, love, and humility, which facilitates resilience”; (2) “The characteristics of the association, a non-medical place between people sharing a common destiny, resonates with patients’ needs and improves their well-being”; (3) “The association transforms the patients’ experiences by facilitating engagement that leads to a patient-expert (empowerment)”; and (4) “Understanding what is happening to them is soothing, reassuring, because patients’ concerns need to be heard ant their care understood”.Conclusions: This study highlights patient associations can serve as the mediator of NPI and facilate the empowerment of breast cancer patient Practice implications: Educating health professionals in initial and continuing education about non-pharmacological interventions will be a major issue. Teaching the patient-centred approach to health professionals is one of the priorities in initial and continuing medical education.