bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs
Authors: Hasan Md Fayad , Berdichevsky Yevgeny 
Published: May 2021

AbstractAggregation and self-sorting of cells in three dimensional cultures have been described for non-neuronal cells. Despite increased interest in engineered neural tissues for treating brain injury or for modeling neurological disorders in vitro, little data is available on collective cell movements in neuronal aggregates. Migration and sorting of cells may alter these constructs’ morphology and, therefore, the function of their neural circuitry. In this work, linear, adhered rat and human 3D neuronal-astrocyte cultures were developed to enable the study of aggregation and sorting of these cells. An in silico model of the contraction, clustering, and cell sorting in the 3D cultures was also developed. Experiments and computational modeling showed that aggregation was mainly a neuron mediated process, and formation of astrocyte-rich sheaths in 3D cultures depended on differential attraction between neurons and astrocytes. In silico model predicted formation of self-assembled neuronal layers in disk-shaped 3D cultures. Neuronal activity patterns were found to correlate with local morphological differences. This model of neuronal and astrocyte aggregation and sorting may benefit future design of neuronal constructs.
Impact glasses from Belize represent tektites from the Pleistocene Pantasma impact crater in Nicaragua
Authors: Rochette Pierre , Beck Pierre , Bizzarro Martin , Braucher Régis , Cornec Jean , Debaille Vinciane , Devouard Bertrand , Gattacceca Jérôme , Jourdan Fred , Moustard Fabien , Moynier Frédéric , Nomade Sébastien , Reynard Bruno 
Published: May 2021

AbstractTektites are terrestrial impact-generated glasses that are ejected long distance (up to 11,000 km), share unique characteristics and have a poorly understood formation process. Only four tektite strewn-fields are known, and three of them are sourced from known impact craters. Here we show that the recently discovered Pantasma impact crater (14 km diameter) in Nicaragua is the source of an impact glass strewn-field documented in Belize 530 km away. Their cogenesis is documented by coincidental ages, at 804 ± 9 ka, as well as consistent elemental compositions and isotopic ratios. The Belize impact glass share many characteristics with known tektites but also present several peculiar features. We propose that these glasses represent a previously unrecognized tektite strewn-field. These discoveries shed new light on the tektite formation process, which may be more common than previously claimed, as most known Pleistocene >10 km diameter cratering events have generated tektites.
Optimization of metal–organic framework derived transition metal hydroxide hierarchical arrays for high performance hybrid supercapacitors and alkaline Zn-ion batteries
Authors: Wang You , Wang Teng , Lei Jiaqi , Chen Kai-Jie 
Published: May 2021

A Setaria viridis-like hierarchical A-Co(OH)2@NiCo-LDH nanoarray has been fabricated and it possesses the advantages of large surface area and stable microstructure, leading to excellent energy storage performances of HSC and AZIB.
Self-assembled luminescent Cu(i) tetranuclear metallacycles based on 3,3′-bipyridine ligands
Authors: Moutier Florent , Schiller Jana , Calvez Guillaume , Lescop Christophe 
Published: May 2021

Three luminescent tetranuclear macrocycles are obtained selectively, applying coordination-driven supramolecular processes to the reaction of 3,3′-bipyridine ligand with in situ formed Cu(i) bimetallic units bearing a coordination angle of ca. 120°.
Low phase noise microwave oscillator with greater than 60 dB second‐harmonic suppression
Authors: Xu Jun , Yang Xiuqiang , Chen Yang , Cao Yu , Xiao Fei 
Published: May 2021

AbstractThis study presents a microwave oscillator in which an innovative hybrid microstrip and substrate integrated waveguide filter is proposed for phase noise reduction. By virtue of equivalent circuit, the specific topology of this filter is clearly revealed and verified by both the simulation and the experiment. It can realize a third‐order elliptic bandpass response with two transmission zeros near the passband. Specific phase response can be formed, in which a high group delay can be achieved within a narrow frequency range around the centre frequency. This feature makes the filter performance very flexible for its application in microwave oscillator, and then reduces its phase noise. For demonstration, an oscillator example at 9.0 GHz was deigned, fabricated and measured. The measured phase noise at 100 kHz away from the oscillation frequency is as low as −120.06 dBc/Hz. Furthermore, the proposed oscillator is featured by greater than 60 dB second‐harmonic suppression and at least the third harmonic is suppressed.
A reliability‐based optimal μ‐PMU placement scheme for efficient observability enhancement of smart distribution grids under various contingencies
Authors: Abdolahi Arya , Taghizadegan Navid , Banaei Mohamad Reza , Salehi Javad 
Published: May 2021

AbstractA reliability‐based optimal μ‐PMU (micro‐phasor measurement unit) placement scheme is suggested for efficient observability enhancement of smart distribution grids at steady‐state and contingencies conditions. This article introduces a unique method for the μ‐PMU allocation in reconfigurable smart distribution grids in which communication system requirements and zero injection nodes (ZINs) are considered. The original objective function and limitations are proposed aiming at minimizing the capital cost, including communication links and installation costs of μ‐PMU, optical power ground wire cost, power losses cost, and reliability cost as well as obtaining the maximum number of measurement redundancy constrained to full system observability in the presence of ZINs and tie switches. The suggested method is formulated as a mixed‐integer linear programming problem applied to find optimal μ‐PMU locations considering the cost of communication infrastructure and co‐optimize the system switching plan simultaneously. In this regard, CPLEX—a high‐performance mathematical solver—is used to solve the proposed mixed‐integer linear optimization problem to reach the global optimality. The simulations are performed on 33, 69, and 85‐bus radial distribution networks, and comprehensive simulation studies show the effectiveness of the suggested method.
An aggregator‐based resource allocation in the smart grid using an artificial neural network and sliding time window optimization
Authors: Zheng Yingying , Celik Berk , Suryanarayanan Siddharth , Maciejewski Anthony A. , Siegel Howard Jay , Hansen Timothy M. 
Published: May 2021

AbstractThe success of an efficient and effective aggregator‐based residential demand response system in the smart grid relies on the day‐ahead customer incentive pricing (CIP) and the load shifting protocols. An artificial neural network model is designed to generate the day‐ahead CIP for the aggregator based on historical data. Load scheduling is proposed as a day‐ahead optimization problem that is solved using a blocked sliding window technique using parallel computing. With the assumptions made, the proposed algorithm improved the aggregator performance by reducing the overall simulation time from 275 to 45 min and increasing the aggregator forecast profits and customer savings by 11.85% and 35.99% compared to the previous genetic algorithm‐based approach.
Internationale Projekte zur homöopathischen Behandlung von Covid-19
Authors: Gerstenhöfer Anna 
Published: May 2021

ZusammenfassungCovid-19 ist eine globale Herausforderung. Im Folgenden werden 3 Projekte vorgestellt, die durch eine produktive internationale Zusammenarbeit getragen werden: Robbert van Haselen regt das Verfassen von qualitativ hochwertigen Covid-19-Fallberichten (Case Reports) an. Praktische Formularvorlagen helfen bei der Erstellung (HOM-CASE-CARE-Richtlinie, MONARCH-Kriterien). Lex Rutten hat auf die ihm vorliegenden Falldaten das Bayes-Theorem angewandt und auf Basis dieser mathematischen Analyse eine App entwickelt, die schnell und konkret Hinweise zur Arzneiwahl liefern kann. Clificol® (Clinical File Collection) ist eine Onlineplattform zur Sammlung von Falldokumentationen, die die Möglichkeit bietet, unsere klinischen Erfahrungen international auszutauschen. Yvonne Fok berichtet über erste Ergebnisse des dieser Datenbank angegliederten Covid-19-Supportprojekts.
Covid-19 im Lichte chronischer Krankheiten
Authors: Witzig Friedrich 
Published: May 2021

ZusammenfassungCovid-19 ist nach Ansicht des Autors eine harmlose Erkältungskrankheit, denn: Komplikationen sind nicht dem Virus geschuldet, sondern dem Umstand, dass Covid-19 sich mit anderen Krankheiten vermischt. Die „verlarvte“ Syphilis dient dafür als Modell. In dieser Mischform ist Covid-19 schwer zu behandeln. Nosoden erweisen sich für diese Mischformen als ähnlichste Arzneien.
Radioembolization for Metastatic Neuroendocrine Tumors
Authors: El-Haddad Ghassan , Strosberg Jonathan 
Published: May 2021

AbstractTransarterial radioembolization (TARE) using β-emitting yttrium-90 microspheres has been used for decades in patients with liver-dominant unresectable metastatic neuroendocrine tumors (mNETs). TARE is one of the embolotherapies supported by the National Comprehensive Cancer Network, among other guidelines, for progressive or symptomatic liver-dominant mNETs. Initial studies with relatively short-term follow-up have indicated that TARE is likely to be at least as effective in controlling symptoms and/or disease progression in the liver as bland or chemoembolization. However, more recent data have shed new light on the risk of long-term hepatotoxicity in patients with mNETs treated with TARE. In this article, we will discuss rationale for TARE, clinical indications, outcomes, and toxicity, as well as new strategies to enhance efficacy of TARE while reducing its toxicity in the treatment of liver-dominant mNETs.
Peripheral and Central Smell Regions in Migraine Patients using Maraş Powder (Smokeless Tobacco): A Magnetic Resonance Imaging Evaluation
Authors: Doğan Adil , Bayar Muluk Nuray , Inanç Yılmaz 
Published: May 2021

Abstract
Objective In the present study, we investigated the efficacy of Maraş powder (smokeless tobacco) use on smell regions in migraine patients.
Methods The cranial magnetic resonance imaging images of 58 adult patients were included in this retrospective study. Thirty-eight of them were migraine patients (18 of them using Maraş powder and 20 of them not using Maraş powder) and 20 of them were healthy controls. Bilateral peripheral (olfactory bulb [OB] volume and olfactory sulcus depth) and central smell regions (insular gyrus area and corpus amygdala area) as well as nasal septal deviation were evaluated.
Results In migraine patients (using or not using Maraş powder), OB volumes, and in Maraş powder using migraine patients, corpus amygdala areas were lower than those in the control group (p < 0.05). In Maraş powder-using migraine patients, left insular gyrus areas of the females were significantly lower than the males (p < 0.05).
Conclusion We concluded that the peripheral smell region of the OB volume decreased in migraine patients (using or not using Maraş powder). However, the central smell region of corpus amygdala area decreased in Maraş powder using migraine patients. Maraş powder usage may increase vascular shrinkage, and the decrease in OB volume and corpus amygdala area becomes prominent. It can be said that Maraş powder usage may cause a size decrease in the peripheral and central smell regions in migraine patients. Therefore, migraine patients and non-migrainous people should be noticed for the harmful effects of Maraş powder on the vascular system and smell system in the aspects of OB volume and corpus amygdala area decrease.
Radioembolization for Metastatic Colorectal Cancer
Authors: Guez David , Sutphin Patrick D. , Ganguli Suvranu 
Published: May 2021

AbstractThe liver is the most common site of metastatic disease in colorectal cancer, and, in the setting of liver-dominant disease, a chief contributor to mortality. Chemotherapy is the backbone of treatment for metastatic colorectal cancer; however, the duration of response is limited and resistance to therapy inevitably develops. Radioembolization represents a targeted treatment to the liver which has been studied in first-line, second-line, and in salvage treatment. Therapeutic rationale, outcomes, and prognostic indicators are presented in this systematic review article.
Effect of Posterior Tibial Slope Change on Postoperative Range of Motion and Clinical Outcomes after Posterior Cruciate-Substituting Total Knee Arthroplasty
Authors: Lee O-Sung , Lee Jangyun , Lee Myung Chul , Han Hyuk-Soo 
Published: May 2021

AbstractThe posterior tibial slope (PTS) is usually adjusted by less than 5 degrees, without considering its individual difference, during posterior cruciate-substituting (PS) total knee arthroplasty (TKA). The effect of these individual changes of PTS would be important because clinical results depending on postoperative PTS were reported conflictingly. We investigated the effect of the change in PTS on the postoperative range of motion (ROM) and clinical scores after PS TKA. We retrospectively reviewed 164 knees from 107 patients who underwent PS TKA with a 2-year follow-up. We analyzed the preoperative and postoperative PTS, ROM, visual analog scale pain scale, Western Ontario and McMaster University Index (WOMAC), Hospital for Special Surgery Knee Score, Knee Society Score, and Forgotten Joint Score (FJS). The association of the absolute change in PTS with ROM and clinical scores was analyzed using correlation analysis and multiple regression analysis. As a result, the mean PTS and mean ROM changed from 9.6 ±  3.4 and 120.1 ±  15.4 degrees preoperatively to 2.0 ±  1.3 and 128.4 ±  9.3 degrees postoperatively, and the mean PTS change was 7.6 ±  3.5 degrees. The PTS change had no statistically significant association with the postoperative ROM and clinical scoring systems, although it did have a weak positive correlation with WOMAC function, No 10 (difficulty in rising from sitting) (correlation coefficient = 0.342, p = 0.041), and moderate positive correlation with the FJS, No. 6 (awareness when climbing stairs) (correlation coefficient = 0.470, p = 0.001). The authors concluded that the amount of change in PTS did not affect the postoperative ROM and clinical scores, although proximal tibial resection with a constant target of PTS resulted in individually different changes in the PTS after PS TKA,
Rise and fall of the global conversation and shifting sentiments during the COVID-19 pandemic
Authors: Zhang Xiangliang , Yang Qiang , Albaradei Somayah , Lyu Xiaoting , Alamro Hind , Salhi Adil , Ma Changsheng , Alshehri Manal , Jaber Inji Ibrahim , Tifratene Faroug , Wang Wei , Gojobori Takashi , Duarte Carlos M. , Gao Xin 
Published: May 2021

AbstractSocial media (e.g., Twitter) has been an extremely popular tool for public health surveillance. The novel coronavirus disease 2019 (COVID-19) is the first pandemic experienced by a world connected through the internet. We analyzed 105+ million tweets collected between March 1 and May 15, 2020, and Weibo messages compiled between January 20 and May 15, 2020, covering six languages (English, Spanish, Arabic, French, Italian, and Chinese) and represented an estimated 2.4 billion citizens worldwide. To examine fine-grained emotions during a pandemic, we built machine learning classification models based on deep learning language models to identify emotions in social media conversations about COVID-19, including positive expressions (optimistic, thankful, andempathetic), negative expressions (pessimistic, anxious, sad, annoyed, anddenial), and a complicated expression,joking, which has not been explored before. Our analysis indicates a rapid increase and a slow decline in the volume of social media conversations regarding the pandemic in all six languages. The upsurge was triggered by a combination of economic collapse and confinement measures across the regions to which all the six languages belonged except for Chinese, where only the latter drove conversations. Tweets in all analyzed languages conveyed remarkably similar emotional states as the epidemic was elevated to pandemic status, including feelings dominated by a mixture ofjokingwithanxious/pessimistic/annoyedas the volume of conversation surged and shifted to a general increase in positive states (optimistic,thankful, andempathetic), the strongest being expressed in Arabic tweets, as the pandemic came under control.
Behavior of S, SO, and SO3 on Pt (001), (011), and (111) surfaces: A DFT study
Authors: Ungerer Marietjie J. , van Sittert Cornelia G. C. E. , de Leeuw Nora H. 
Published: May 2021

In the hybrid sulfur (HyS) cycle, the reaction between SO2 and H2O is manipulated to produce hydrogen with water and sulfuric acid as by-products. However, sulfur poisoning of the catalyst has been widely reported to occur in this cycle, which is due to strong chemisorption of sulfur on the metal surface. The catalysts may deactivate as a result of these impurities present in the reactants or incorporated in the catalyst during its preparation and operation of the HyS cycle. Here, we report a density functional theory investigation of the interaction between S, SO, and SO3 with the Pt (001), (011), and (111) surfaces. First, we have investigated the adsorption of single gas phase molecules on the three Pt surfaces. During adsorption, the 4F hollow sites on the (001) and (011) surfaces and the fcc hollow site on the (111) surface were preferred. S adsorption followed the trend of (001)4F &gt; (011)4F &gt; (111)fcc, while SO adsorption showed (001)4F &gt; (011)bridge/4F &gt; (111)fcc and SO3 adsorption was most stable in a S,O,O bound configuration on the (001)4F &gt; (011)4F &gt; (111)fcc sites. The surface coverage was increased on all the surfaces until a monolayer was obtained. The highest surface coverage for S shows the trend (001)S = (111)S &gt; (011)S, and for SO it is (001)SO &gt; (011)SO &gt; (111)SO, similar to SO3 where we found (001)SO3 &gt; (011)SO3 &gt; (111)SO3. These trends indicate that the (001) surface is more susceptible to S species poisoning. It is also evident that both the (001) and (111) surfaces were reactive toward S, leading to the formation of S2. The high coverage of SO3 showed the formation of SO2 and SO4, especially on the (011) surface. The thermodynamics indicated that an increased temperature of up to 2000 K resulted in Pt surfaces fully covered with elemental S. The SO coverage showed θ ≥ 1.00 on both the (001) and (011) surfaces and θ = 0.78 for the (111) surface in the experimental region where the HyS cycle is operated. Lower coverages of SO3 were observed due to the size of the molecule.
Innovation of oxygen indicator for packaging leak detector: A review
Authors: Sari A N A , Warsiki E , Kartika I A 
Published: May 2021

Abstract
Oxygen is one of the factors causing the food product damage. Therefore, vacuum packaging or modified atmosphere packaging (MAP) is an effective solution offered. However, there is always a risk of leakage in the package especially in the packaging process, in the distribution process, and by the insect or rodent damage. Therefore, an oxygen indicator that helps retailers and consumers to detect leaks and to prevent them from buying leaking products is created. Its working principle is to show a color change that reflects changes in the composition of the gas. The use of oxygen indicators is beneficial not only for consumers but also for manufacturers of products who use this indicator for loyal consumers to maintain the consumer credibility with their products. Furthermore, technological advances encourage researchers to improve several important aspects of oxygen indicators such as product safety application, product cost retrenchment, ease of manufacture, and environmental friendliness. This article reviews the development of oxygen indicators and the advantages and disadvantages of each type of oxygen indicator and provides information for researchers and the MAP industry on the types of oxygen indicators that are well developed in the future.
TG-DSC investigation of co-combustion characteristics of blends sawdust and coal
Authors: Umar D F , Monika I , Handoko S 
Published: May 2021

Abstract
Co-combustion of biomass and coal in coal fired power plant could reduce CO2 emissions and utilize renewable energy resources. To understand the co-combustion characteristics of biomass and coal blends, thermogravimetry-differential scanning calorimetry (TG-DSC) analysis, as well as proximate, ultimate and heating value have been conducted. TG-DSC measures both weight changes (TG) and heat flow (DSC) in a material as a function of temperature or time in a controlled atmosphere. The combustion profiles can be used to study some combustion properties of fuels and fuel blends. The biomass that used in this study was sawdust in its origin and torrefied sawdust which blend with a low rank coal. The composition of the biomass and coal were 1:3; 1:1 and 3:1 in weight ratio. Results indicated that the blend of coal and torrefied sawdust in weight ratio of 1:3 was the best combustion performance compared to the other composition, indicated by the highest of ignition temperature (Tig), maximum combustion rate (Rmax) and heating value.
Clustering analysis for production system design of emulsifier for biodiesel B30 based on digital business ecosystem
Authors: Dimawarnita F , Djatna T , Hambali E , Muslich  , Panji Tri , Adnan A A 
Published: May 2021

Abstract
Biodiesel in Indonesia is synthesized from palm oil into Fatty Acid Methyl Ester (FAME). In Biodiesel B30, FAME and diesel fuels cannot be homogeneous because FAME is hygroscopic and has a higher density than diesel fuels. This problem can be solved by adding emulsifiers. However, the emulsifier production process is currently limited to the laboratory scale. So, it is necessary to simulate the scaling up emulsifier production system and also the classification of the emulsifier product in the quality control section for this process production. Its integration processes and product are also not following the quality standard. This study aims to identify the relation of emulsifier formulation’s attributes then classify the quality according to the emission of NOx gas. The methods used to determine analyzed system requirements are using BPMN 2.0. The rules are then compiled from the existing emulsifier production system using Association Rules Mining (ARM), and the K-means algorithm will cluster the result. These rules can be used as a reference in taking influential attributes for emulsifier formulation. K-Means algorithm models the rules from the ARM into clusters where data in one cluster has the same characteristics and different characteristics from other clusters. The dataset used is hypothetical data from the formulation and quality testing of the emulsifier. This study’s final results are ten attributes that were approved in the emulsifier formulation and 4 clusters of emulsifier product quality based on NOx gas emissions and separated water layers.