bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying resting locations of a small elusive forest carnivore using a two-stage model accounting for GPS measurement error and hidden behavioral states
Authors: Hance Dalton J. , Moriarty Katie M. , Hollen Bruce A. , Perry Russell W. 
Published: April 2021

Abstract
Background
Studies of animal movement using location data are often faced with two challenges. First, time series of animal locations are likely to arise from multiple behavioral states (e.g., directed movement, resting) that cannot be observed directly. Second, location data can be affected by measurement error, including failed location fixes. Simultaneously addressing both problems in a single statistical model is analytically and computationally challenging. To both separate behavioral states and account for measurement error, we used a two-stage modeling approach to identify resting locations of fishers (Pekania pennanti) based on GPS and accelerometer data.

Methods
We developed a two-stage modelling approach to estimate when and where GPS-collared fishers were resting for 21 separate collar deployments on 9 individuals in southern Oregon. For each deployment, we first fit independent hidden Markov models (HMMs) to the time series of accelerometer-derived activity measurements and apparent step lengths to identify periods of movement and resting. Treating the state assignments as given, we next fit a set of linear Gaussian state space models (SSMs) to estimate the location of each resting event.

Results
Parameter estimates were similar across collar deployments. The HMMs successfully identified periods of resting and movement with posterior state assignment probabilities greater than 0.95 for 97% of all observations. On average, fishers were in the resting state 63% of the time. Rest events averaged 5 h (4.3 SD) and occurred most often at night. The SSMs allowed us to estimate the 95% credible ellipses with a median area of 0.12 ha for 3772 unique rest events. We identified 1176 geographically distinct rest locations; 13% of locations were used on > 1 occasion and 5% were used by > 1 fisher. Females and males traveled an average of 6.7 (3.5 SD) and 7.7 (6.8 SD) km/day, respectively.

Conclusions
We demonstrated that if auxiliary data are available (e.g., accelerometer data), a two-stage approach can successfully resolve both problems of latent behavioral states and GPS measurement error. Our relatively simple two-stage method is repeatable, computationally efficient, and yields directly interpretable estimates of resting site locations that can be used to guide conservation decisions.
Ligand-modulated synthesis of gold nanoclusters for sensitive and selective detection of folic acid
Authors: Li Xiangfei , Qiao Juan , Sun Yongjun , Li Zhiwei , Qi Li 
Published: April 2021

AbstractPrecisely changing the optical properties of gold nanoclusters (AuNCs) with different ligands offers a promising prospect for highly sensitive and selective drug sensing. In this study, AuNCs were synthesized with d-tryptophan (d-Trp) and its derivatives as the ligands. Optical measurements showed that d-Trp@AuNCs produced higher fluorescence intensity and shorter fluorescence emission wavelength than the d-Trp-derivatives-ligands protected AuNCs, indicating that the ligand-shell rigidity and core-shell charge transfer affected their fluorescent properties. At the excitation wavelength of 370 nm, the emission wavelength of d-Trp@AuNCs was 460 nm. The fluorescence changes revealed the high selectivity of d-Trp@AuNCs for detecting folic acid due to the static quenching and inner filter effect. In the presence of folic acid, the fluorescence of d-Trp@AuNCs was remarkably quenched with good linearity ranging from 6.3-100.0 μM (R2 = 0.997) and a detection limit of 5.8 μM. The proposed assay was successfully utilized to determine the amount of folic acid in human urine with recoveries from 94.3 to 107.3%. This work shows the great potential of d-Trp@AuNCs for detecting folic acid in real bio-samples. It also presents an effective strategy for preparation of the AuNCs with enhanced fluorescence efficiency by regulating the rigidity of the ligands shell and the core-shell charge transfer.
Determination of tyrosine by sodium fluorescein-enhanced ABEI–H2O2–horseradish peroxidase chemiluminescence
Authors: Dong Bin , Fan Qian , Li Ming , Huan Yanfu , Feng Guodong , Shan Hongyan , Fei Qiang 
Published: April 2021

AbstractIn this study, N-(4-aminobutyl)-N-ethylisoluminol (ABEI) was used as an energy donor, while sodium fluorescein was used as an enhancer and energy acceptor, which resulted in it producing resonance energy transfer and greatly increasing the strength of chemiluminiscence (CL). When horseradish peroxidase (HRP) is added, hydrogen peroxide (H2O2) will quickly separate into hydroxyl radicals (·OH) and superoxide ions (O2·−). If tyrosine (Tyr) is present in the system, the hydroxyl group on the benzene ring of Tyr robs ·OH and O2·− in the CL system, thereby reducing the intensity of CL. Based on this phenomenon, a luminescence system of ABEI and sodium fluorescein system was established to detect Tyr for the first time. This method has an ultra-low detection limit and a wide linear range, and is cheap and easy to operate. Under various optimal conditions, the linear range is from 3.0×10−8 to 3.0×10−5 mol/L, and the limit of detection is 2.4×10−8 mol/L. It has been successfully used in the detection of dairy products with satisfactory results.
A potential suite of climate markers of long-chain n-alkanes and alkenones preserved in the top sediments from the Pacific sector of the Southern Ocean
Authors: Chen Xin , Liu Xiaodong , Lin Da-Cheng , Wang Jianjun , Chen Liqi , Yu Pai-Sen , Wang Linmiao , Xiong Zhifang , Chen Min-Te 
Published: April 2021

AbstractInvestigating organic compounds in marine sediments can potentially unlock a wealth of new information in these climate archives. Here, we present pilot study results of organic geochemical features of long-chain n-alkanes and alkenones and individual carbon isotope ratios of long-chain n-alkanes from a newly collected, approximately 8 m long, located in the far reaches of the Pacific sector of the Southern Ocean. We analyzed a suite of organic compounds in the core. The results show abundant long-chain n-alkanes (C29–C35) with predominant odd-over-even carbon preference, suggesting an origin of terrestrial higher plant waxes via long-range transport of dust, possibly from Australia and New Zealand. The δ13C values of the C31n-alkane range from −29.4 to −24.8‰, in which the higher δ13C values suggest more contributions from C4 plant waxes. In the analysis, we found that the mid-chain n-alkanes (C23–C25) have a small odd-over-even carbon preference, indicating that they were derived from marine non-diatom pelagic phytoplankton and microalgae and terrestrial sources. Furthermore, the C26 and C28 with lower δ13C values (~−34‰) indicate an origin from marine chemoautotrophic bacteria. We found that the abundances of tetra-unsaturated alkenones (C37:4) in this Southern Ocean sediment core ranges from 11 to 37%, perhaps a marker of low sea surface temperature (SST). The results of this study strongly indicate that the δ13C values of long-chain n-alkanes and $$ {U}_{37}^{\mathrm{k}} $$

U
37
k

index are potentially useful to reconstruct the detailed history of C3/C4 plants and SST change in the higher latitudes of the Southern Ocean.
The role of activity, scan duration and patient’s body mass index in the optimization of FDG imaging protocols on a TOF-PET/CT scanner
Authors: Matheoud Roberta , Al-Maymani Naema , Oldani Alessia , Sacchetti Gian Mauro , Brambilla Marco , Carriero Alessandro 
Published: April 2021

Abstract
Background
Time-of-flight (TOF) PET technology determines a reduction in the noise and improves the reconstructed image quality in low count acquisitions, such as in overweight patients, allowing a reduction of administered activity and/or imaging time. However, international guidelines and recommendations on the 18F-fluoro-2-deoxyglucose (FDG) activity administration scheme are old or only partially account for TOF technology and advanced reconstruction modalities.
The aim of this study was to optimize FDG whole-body studies on a TOF-PET/CT scanner by using a multivariate approach to quantify how physical figures of merit related to image quality change with acquisition/reconstruction/patient-dependent parameters in a phantom experiment.

Methods
The NEMA-IQ phantom was used to evaluate contrast recovery coefficient (CRC), background variability (BV) and contrast-to-noise ratio (CNR) as a function of changing emission scan duration (ESD), activity concentration (AC), target internal diameter (ID), target-background activity ratio (TBR) and body mass index (BMI). The phantom was filled with an average concentration of 5.3 kBq/ml of FDG solution and the spheres with TBR of 21.2, 8.8 and 5.0 in 3 different sessions. Images were acquired at varying background activity concentration from 5.1 to 1.3 kBq/ml, and images were reconstructed for ESD of 30–151 s per bed position with and without point spread function (PSF) correction. The parameters were all considered in a single analysis using multiple linear regression methods.

Results
As expected, CRC depended only on sphere ID and on PSF application, while BV depended on sphere ID, ESD, AC and BMI of the phantom, in order of decreasing relevance. Noteworthy, ESD and AC resulted as the most significant predictors of CNR variability with a similar relevance, followed by the BMI of the patient and TBR of the lesion.

Conclusions
AC and ESD proved to be effective tools in modulating CNR. ESD could be increased rather than AC to improve image quality in overweight/obese patients to fulfil ALARA principles.
Finite element analysis for identifying locations of cracking and hydraulic fracturing in homogeneous earthen dams
Authors: Talukdar Priyanka , Dey Arindam 
Published: April 2021

AbstractThis paper reports a finite element study to identify the locations of crack initiation in a homogeneous earthen dam at its post-construction and reservoir operation stages. The steady state and transient analyses, including reservoir rise-up and drawdown conditions, are simulated to identify the favorable conditions and locations of crack generation. The behavioral response of the dam is represented in terms of the developed total stress, horizontal deformations of the faces, strain accumulation in the dam, and the differential settlement of the dam base. The locations of post-construction cracks are identified based on the negative minor principal stresses developed on the dam faces. For both single-lift and multiple-lift modeling techniques, the upstream face of the dam is found to be the most favorable location for the crack generation. For transient reservoir operations (rise-up and drawdown scenarios), it is identified that hydraulic fracturing may occur on either faces of the dam at specific heights, governed by the minor principal stresses becoming lesser than the developed pore-water pressure. Depending on whether the reservoir drawdown occurs before or after the attainment of steady-state phreatic level within the body of the dam, the pore-water pressure distribution within the dam are found notably different. This results in hydraulic fracturing occurring at different faces of the dam and at different heights. It is important to have a thorough understanding of the tentative location of the cracks developed in homogeneous earthen dams so that proper mitigation measure can be adopted as per requirement.
Storytelling in early childhood education: Time to go digital
Authors: Rahiem Maila D. H. 
Published: April 2021

AbstractDigital storytelling blends the ancient art of storytelling with a range of contemporary tools to weave stories together with the author's narrative voice, including digital images, graphics, music and sound. Digital storytelling, as both a teaching method and a learning resource, has been applied in many innovative ways at all levels of education. Digital storytelling supports student learning and allows teachers to adopt innovative and improved teaching methods. Storytelling is a proven and popular pedagogy, while digital storytelling is relatively recent and still seldom used in the setting of early childhood education. Using a case study of a storytelling–art–science club in Jakarta, Indonesia, the researcher explored how and why digital storytelling is used in early childhood education. This club is one of the few organizations that use digital storytelling for teaching and learning programs in early childhood. Data were collected qualitatively using in-depth interviews with four teachers, document analysis, and twice-observations of storytelling activities in each session with 35 and 37 children. The collected data were analyzed using analytical memoing methods. The results indicate that teachers in this club used digital storytelling for several important reasons. They claimed that simple digital technology made storytelling more entertaining, captivating, engaging, communicative and theatrical. This study suggests that the ability of teachers to use digital technology should be enhanced; schools' information and communication technology (ICT) devices should be equipped; some funding should also be allocated by the government to modernize school equipment; while the curriculum should be tailored to meet technological developments, and provide opportunities for children to learn how to make good use of technology.
Changes in quantifiable breathing pattern components predict asthma control: an observational cross-sectional study
Authors: Sakkatos Panagiotis , Bruton Anne , Barney Anna 
Published: April 2021

Abstract
Background
Breathing pattern disorders are frequently reported in uncontrolled asthma. At present, this is primarily assessed by questionnaires, which are subjective. Objective measures of breathing pattern components may provide additional useful information about asthma control. This study examined whether respiratory timing parameters and thoracoabdominal (TA) motion measures could predict and classify levels of asthma control.

Methods
One hundred twenty-two asthma patients at STEP 2- STEP 5 GINA asthma medication were enrolled. Asthma control was determined by the Asthma Control Questionnaire (ACQ7-item) and patients divided into ‘well controlled’ or ‘uncontrolled’ groups. Breathing pattern components (respiratory rate (RR), ratio of inspiration duration to expiration duration (Ti/Te), ratio of ribcage amplitude over abdominal amplitude during expiration phase (RCampe/ABampe), were measured using Structured Light Plethysmography (SLP) in a sitting position for 5-min. Breath-by-breath analysis was performed to extract mean values and within-subject variability (measured by the Coefficient of Variance (CoV%). Binary multiple logistic regression was used to test whether breathing pattern components are predictive of asthma control. A post-hoc analysis determined the discriminant accuracy of any statistically significant predictive model.

Results
Fifty-nine out of 122 asthma patients had an ACQ7-item < 0.75 (well-controlled asthma) with the rest being uncontrolled (n = 63). The absolute mean values of breathing pattern components did not predict asthma control (R2 = 0.09) with only mean RR being a significant predictor (p < 0.01). The CoV% of the examined breathing components did predict asthma control (R2 = 0.45) with all predictors having significant odds ratios (p < 0.01). The ROC curve showed that cut-off points > 7.40% for the COV% of the RR, > 21.66% for the CoV% of Ti/Te and > 18.78% for the CoV% of RCampe/ABampe indicated uncontrolled asthma.

Conclusion
The within-subject variability of timing parameters and TA motion can be used to predict asthma control. Higher breathing pattern variability was associated with uncontrolled asthma suggesting that irregular resting breathing can be an indicator of poor asthma control.
Etiology and management of hypertension in patients with cancer
Authors: Mohammed Turab , Singh Meghana , Tiu John G. , Kim Agnes S. 
Published: April 2021

AbstractThe pathophysiology of hypertension and cancer are intertwined. Hypertension has been associated with an increased likelihood of developing certain cancers and with higher cancer-related mortality. Moreover, various anticancer therapies have been reported to cause new elevated blood pressure or worsening of previously well-controlled hypertension. Hypertension is a well-established risk factor for the development of cardiovascular disease, which is rapidly emerging as one of the leading causes of death and disability in patients with cancer. In this review, we discuss the relationship between hypertension and cancer and the role that hypertension plays in exacerbating the risk for anthracycline- and trastuzumab-induced cardiomyopathy. We then review the common cancer therapies that have been associated with the development of hypertension, including VEGF inhibitors, small molecule tyrosine kinase inhibitors, proteasome inhibitors, alkylating agents, glucocorticoids, and immunosuppressive agents. When available, we present strategies for blood pressure management for each drug class. Finally, we discuss blood pressure goals for patients with cancer and strategies for assessment and management. It is of utmost importance to maintain optimal blood pressure control in the oncologic patient to reduce the risk of chemotherapy-induced cardiotoxicity and to decrease the risk of long-term cardiovascular disease.
Research on power control strategy of household-level electric power router based on hybrid energy storage droop control
Authors: Huang Kun , Li Yanman , Zhang Xiaoyan , Liu Lei , Zhu Yanbin , Meng Xin 
Published: April 2021

AbstractIn the light of user-side energy power control requirements, a power control strategy for a household-level EPR based on HES droop control is proposed, focusing on the on-grid, off-grid and seamless switching process. The system operating states are divided based on the DC bus voltage information with one converter used as a slack terminal to stabilize the DC bus voltage and the other converters as power terminals. In the on-grid mode, the GCC and the HES are used as the main control unit to achieve on-grid stable operation, whereas in the off-grid mode, the PV, HES and LC are used as the main control unit at different voltages to achieve stable operation of the island network. Finally, a DC MG system based on a household-level EPR is developed using the PSCAD / EMTDC simulation platform and the results show that the control strategy can effectively adjust the output of each subunit and maintain the stability of the DC bus voltage.
Is it worth to perform initial non-operative treatment for patients with acute ACL injury?: a prospective cohort prognostic study
Authors: Park Yong-Geun , Ha Chul-Won , Park Yong-Beom , Na Sang-Eun , Kim Manyoung , Kim Tae Seon , Chu Yong Yeon 
Published: April 2021

Abstract
Purpose
To evaluate the result of implementing an initial non-operative treatment program for an acute ACL injury and to find if the timing of initiating the non-operative treatment is significant.

Methods
This study included a prospective cohort of 85 consecutive patients with acute ACL injury who were treated according to the above strategy for the initial 3 months with 1-year follow-up. Clinical evaluations were made by Lysholm score, Tegner activity score, Lachman test (LT), pivot-shit test (PST), and the side to side difference (SSD) by KT-2000 arthrometer. The results were analyzed according to the timing of initiating the non-operative treatment.

Results
Initially, 84% of the patients showed LT and PST ≤ grade 1, and 16% with ≥grade 2. At 1-year follow-up, 77 patients (91%) with LT and PST ≤ grade 1 did not receive reconstruction as copers and 8 patients with LT or PST ≥ grade 2 required reconstruction (six patients received the operation and two refused). The patients with LT and PST ≤ grade 1 showed average Lysholm score 91.2, average SSD 2.5 mm, and mean Tegner score decreased from 6.9 (pre-injury) to 6.2. Patients who started the non-operative treatment within 2 weeks after injury revealed superior rates of grade 0 or 1 instability than those who commenced the treatment later than 2 weeks after injury (P = 0.043).

Conclusions
Implementing a non-operative treatment with brace in acute phase of ACL injury appears to be an effective and viable option to achieve a reasonable clinical outcome. We recommend earlier initiation of the non-operative treatment to obtain a better result in patients with acute ACL injury.
Chest CT in COVID-19 pneumonia: correlations of imaging findings in clinically suspected but repeatedly RT-PCR test-negative patients
Authors: Korkmaz Inan , Dikmen Nursel , Keleş Fatma Oztürk , Bal Tayibe 
Published: April 2021

Abstract
Background
To emphasize the importance of CT in the diagnosis of COVID-19 disease by comparing the thoracic CT findings of COVID-19 patients with positive RT-PCR results and patients with clinical suspicion of COVID-19 but with negative RT-PCR results.

Results
In our study, COVID-19 patients with positive RT-PCR results (RT-PCR (+) group) and patients with clinical suspicion of COVID-19 but negative RT-PCR results (RT-PCR (−) group) were compared in terms of CT findings. In CT images, ground-glass opacity and ground-glass opacity + patchy consolidation were the most common lesion patterns in both groups. No statistically significant differences in the rates and types of lesion patterns were observed between the two groups. In both groups, lesion distributions and distribution patterns were similarly frequent in the bilateral, peripheral, and lower lobe distributions. Among the 39 patients who underwent follow-up CT imaging in the first or second month, a regression in lesion number and density was detected in 18 patients from both groups. Consolidations were completely resorbed in 16 of these patients, and five patients had newly developed fibrotic changes. The follow-up CT examination of 16 patients was normal.

Conclusions
Due to the false-negative rate of RT-PCR tests caused by various reasons, clinically suspected COVID-19 patients with a contact history should be examined with CT scans, even if RT-PCR tests are negative. If the CT findings are positive, these patients should not be removed from isolation.