bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 on the performance of emerging market mutual funds: evidence from India
Authors: Maheen Muhammad Sali 
Published: October 2021

AbstractThe purpose of this paper is to examine the widely believed beating capacity of actively managed funds during the market downturn. This popular hypothesis has been tested with the performance of Indian Equity Mutual Funds during the pandemic period. The conditional alphas are estimated using lagged instrumental variables with the fixed effect/LSDV estimator and the sys-GMM estimator in contrast to the OLS estimation from a sample of 1271 schemes for 5 months from 1st March 2020 to 31st July 2020. The study’s findings indicate that the actively managed Indian mutual fund co-moves with the market and does not possess the ability to beat the market. The major implication comes from the application of fixed effect and GMM estimators for the performance evaluation of Indian Mutual Funds’ during the crisis period, and it serves the investors in deciding the profitable investment opportunities.
In vitro, acute and subchronic evaluation of the antidiabetic activity of Atractylis flava Desf n-butanol extract in alloxan-diabetic rats
Authors: Melakhessou Mohamed Akram , Marref Salah Eddine , Benkiki Naima , Marref Cherine , Becheker Imene , Khattabi Latifa 
Published: October 2021

Abstract
Background
Diabetes mellitus is a serious complex multifactorial disorder that imposes huge health and economic burden on societies. Because the currently available medications have many drawbacks, it's important to look for alternative therapies. Medicinal plants utilized in folk medicine are ideal candidates. Therefore, this work assessed the antidiabetic action of n-butanol extract from the whole plant Atractylis flava Desf (BEAF). These ethnomedicinal properties of BEAF were scientifically validated using in vitro and in vivo assays. In vitro antidiabetic effect of the BEAF was conducted using α-Glucosidase and α-Amylase assays. While the antihyperglycemic activity was assessed using two rat models: Alloxan-induced diabetic rats and oral glucose challenged rats. Experimental diabetes was induced by a single intraperitoneal injection of alloxan at a dose of 150 mg/kg and animals with fasting blood glucose levels (BGL) > 200 mg/dL were considered diabetic. Glibenclamide (5 mg/kg) was used as a typical drug.

Results
The BEAF at all tested dose levels (100, 250, and 500 mg/kg) showed a significant decrease in blood glucose level in all the two animal models. Besides, the plant extract exhibited a potent inhibitory effect on α-Amylase and α-Glucosidase activity at a concentration of 1000 µg/mL with 76.17% and 89.37%, respectively.

Conclusion
BEAF exerts in vitro and in vivo antidiabetic effects, these results suggest that the plant extract can be a therapeutic resource in the treatment of diabetes and hyperlipidemia.
Formulation, optimization, qualitative and quantitative analysis of new dosage form of corticosteroid
Authors: Nazir Arif , Masih Mumtaz , Iqbal Munawar 
Published: October 2021

Abstract
Background
The objective of the present research work is to develop the entirely new drug product formulation (Ophthalmic Suspension) which belongs to the therapeutic class of steroids drugs (Corticosteroid). There are different dosage forms of Triamcinolone acetonide to treat different systemic as well as topical diseases as per patient symptomatic conditions. Due to non-availability of this active drug (Triamcinolone acetonide) ophthalmic dosage form in the national and international market research work is carried out to enter in this dosage form.

Results
In the formulation design and development, different inactive like polysorbate 30 mg/mL, PEG-12 glyceryl dimyristate 70 mg/mL, ethyl alcohol 10 µL/mL, citric acid 1 mg/mL, sodium citrate 3.5–4.0 mg/mL, BKC 0.15 mg/mL and water for injection have been used at different stages in different proportions during the manufacturing procedure. Gradient HPLC, C18 column, 5 µm, 100 A, 3.9 mm × 300 mm, detector UV/Vis @ 254 nm, column oven, auto-sampler, degasser, is used and this analytical testing method is validated to obtain the accurate results. The excipients play different roles including solvent, antioxidant, solubilizer, emulsifier, antibacterial, preservative, anticoagulant, antimicrobial agent, surfactant and buffers in the stability of active drug for its excellent therapeutic output results. Correlation coefficient factor is greater than 0.999 which indicates that the method has good linearity at proposed concentration against triamcinolone acetonide.

Conclusions
Excellent physical and chemical properties like physical appearance, pH, specific gravity, viscosity, re-suspendability, sedimentation volume is accomplished to meet the requirements of the eye treatment products. On the basis of experimental results achieved during validation process, it can be assumed that the current analysis method is more accurate, precise, specific, linear and consistency indicating in the range of 70 to 130% of the analyte concentration. From the physical, chemical behaviors and chemical assay of the newly developed drug formulation of corticosteroid (triamcinolone acetonide) it is concluded that it can be probably put for further clinical trial in different phases for human use.
Dichotomy in the Impact of Elevated Maternal Glucose Levels on Neonatal Epigenome
Authors: Lim Ives Yubin , Lin Xinyi , Teh Ai Ling , Wu Yonghui , Chen Li , He Menglan , Chan Shiao-Yng , MacIsaac Julia L , Chan Jerry K Y , Tan Kok Hian , Chong Mary Foong Fong , Kobor Michael S , Godfrey Keith M , Meaney Michael J , Lee Yung Seng , Eriksson Johan G , Gluckman Peter D , Chong Yap Seng , Karnani Neerja 
Published: October 2021

Abstract

Context
Antenatal hyperglycemia is associated with increased risk of future adverse health outcomes in both mother and child. Variations in offspring’s epigenome can reflect the impact and response to in utero glycemic exposure, and may have different consequences for the child.

Objective
We examined possible differences in associations of basal glucose status and glucose handling during pregnancy with both clinical covariates and offspring cord tissue DNA methylation.

Research Design and Methods
This study included 830 mother-offspring dyads from the Growing Up in Singapore Towards Healthy Outcomes cohort. The fetal epigenome of umbilical cord tissue was profiled using Illumina HumanMethylation450 arrays. Associations of maternal mid-pregnancy fasting (fasting plasma glucose [FPG]) and 2-hour plasma glucose (2hPG) after a 75-g oral glucose challenge with both maternal clinical phenotypes and offspring epigenome at delivery were investigated separately.

Results
Maternal age, prepregnancy body mass index, and blood pressure measures were associated with both FPG and 2hPG, whereas Chinese ethnicity (P = 1.9 × 10-4), maternal height (P = 1.1 × 10-4), pregnancy weight gain (P = 2.2 × 10-3), prepregnancy alcohol consumption (P = 4.6 × 10-4), and tobacco exposure (P = 1.9 × 10-3) showed significantly opposite associations between the 2 glucose measures. Most importantly, we observed a dichotomy in the effects of these glycemic indices on the offspring epigenome. Offspring born to mothers with elevated 2hPG showed global hypomethylation. CpGs most associated with the 2 measures also reflected differences in gene ontologies and had different associations with offspring birthweight.

Conclusions
Our findings suggest that 2 traditionally used glycemic indices for diagnosing gestational diabetes may reflect distinctive pathophysiologies in pregnancy, and have differential impacts on the offspring’s DNA methylome.
Desigualdades de género relacionadas con la flexibilidad laboral
Authors: Cortés Imma , Artazcoz Lucía 
Published: October 2021

Desde mediados de la década de 1970 se han producido profundos cambios en las economías capitalistas occidentales relacionados con factores tecnológicos, políticos y económicos, entre los que destacan la globalización, la liberalización de las políticas laborales, el debilitamiento sindical y las nuevas tecnologías. Estos cambios han ido acompañados de un aumento progresivo de la flexibilidad laboral impulsada por necesidades de las empresas, incrementada en periodos de crisis económica como la de mediados de los años 1990 y la de 2008.
Las estrategias de flexibilidad laboral son diversas. Pueden referirse a las jornadas laborales (tanto en el número de horas trabajadas como en la organización de la jornada), a los salarios, la subcontratación de personas o empresas, y una de las más importantes: la variación del número de personas empleadas mediante la contratación temporal, el despido, etc. En cualquier caso, el aumento de la flexibilidad ha dado lugar a un incremento de nuevas formas de ocupación caracterizadas por altos niveles de inestabilidad laboral y una erosión general de las condiciones de trabajo y ocupación de los trabajadores y trabajadoras. Son formas de ocupación que se acumulan en los grupos de personas en una situación de más vulnerabilidad en el mercado de trabajo debido a su falta de poder. En términos generales, y siguiendo los ejes de desigualdad social, son las personas jóvenes, las personas migradas, las mujeres y las personas con menos nivel de estudios…
Aplicación del cuestionario de autoevaluación de la estrategia multimodal de la OMS para mejorar la práctica de higiene de manos en un hospital de tercer nivel
Authors: De Arriba Fernández Alejando , Molina-Cabrillana Jesús , Serra-Majem Lluís 
Published: October 2021

Objetivo. El objetivo de este trabajo es evaluar la implementación de la aplicación de una estrategia multimodal para impulsar la promoción de la Higiene de Manos (HM).
Métodos. Se utilizó la «Guía de aplicación de la estrategia multimodal de la Organización Mundial de la Salud para la mejora de la higiene de manos». La estrategia se planteó como un estudio de intervención para promover la HM en el Complejo Hospitalario Universitario Insular Materno Infantil en el período 2012-2020.
Resultados. El cumplimiento global de las indicaciones de HM al final del periodo de estudio fue del 59,2%. El consumo de productos de base alcohólica aumentó con respecto a los años anteriores (p<0,05), siendo en el último año de 70 litros por cada 1000 estancias. La encuesta reveló que la formación y la existencia de preparado de base alcohólica en cada punto de atención eran percibidas por parte de los profesionales sanitarios como los principales aspectos facilitadores de la práctica de HM.
Conclusiones. La implementación de una intervención multimodal mejoró significativamente la adhesión al lavado de manos y el uso de productos de base alcohólica entre los profesionales sanitarios. A pesar de tener formación previa sobre higiene de manos, los conocimientos de los profesionales son incompletos. La formación previa seguido del tiempo trabajado son los determinantes más importantes de las conocimientos y percepciones sobre higiene de manos.
Modul Sistem Pencernaan Manusia Berbasis Augmented Reality (AR) sebagai Sumber Belajar
Authors: Yusma Hasna Lathifah  , Sulistiyawati  
Published: October 2021

Penelitian ini bertujuan untuk (1) Mengetahui pengembangan berupa modul berbasis Augmented Reality (AR) pada materi Sistem Pencernaan Manusia sumber belajar variatif (2) Mengetahui kualitas dan kelayakan modul konsep Sistem Pencernaan Manusia berbasis Augmented Reality (AR) sebagai sumber belajar (3) Mengetahui respon siswa terhadap pengembangan modul konsep Sistem Pencernaan Manusia berbasis Augmented Reality (AR) sebagai sumber belajar siswa. Penelitian ini merupakan penelitian pengembangan Research and Development (R&D) dengan model pengembangan mengadaptasi model ADDIE yang terdiri dari Analysis, Design, Development, Implementation, and Evaluation. Namun dalam penelitian tidak dilakukan tahap implementasi karena sumber belajar ini tidak diterapkan dalam kegiatan pembelajaran pada situasi nyata di kelas.Instrumen penelitian yang digunakan berupa lembar angket yang dinilai oleh 1 ahli media, 1 ahli materi,5 peer reviewer, 1 guru biologi, dan angket respon 15 siswa SMA Kelas XI. Berdasarkan penilaian kualitas Modul Sistem Pencernaan Manusia berbasis Augmented Reality (AR) dari ahli materi memperoleh presentase ideal 88% kategori sangat baik, penilaian ahli media memperoleh presentase keidealan 80% kategori sangat baik, penilaian peer reviewer 80% kategori sangat baik, penilaian guru biologi sebesar 88% kategori sangat baik, dan uji coba terbatas oleh 15 siswa SMA kelas XI memperoleh presentase keidealan sebesar 88% dengan kategori sangat setuju untuk digunakan sebagai sumber belajar biologi siswa.
Kata Kunci : Modul, Augmented Reality (AR), Sumber belajar, Sistem Pencernaan Manusia
Locally pro-pcontraction groups are nilpotent
Authors: Glöckner Helge , Willis George A. 
Published: October 2021

AbstractThe authors have shown previously that every locally pro-pcontraction group decomposes into the direct product of ap-adic analytic factor and a torsion factor. It has long been known thatp-adic analytic contraction groups are nilpotent. We show here that the torsion factor is nilpotent too, and hence that every locally pro-pcontraction group is nilpotent.
Obstruction flat rigidity of the CR 3-sphere
Authors: Curry Sean N. , Ebenfelt Peter 
Published: October 2021

Abstract
We consider the obstruction flatness problem for small deformations of the standard CR 3-sphere. That rigidity holds for the CR sphere was previously known (in all dimensions) for the case of embeddable CR structures, where it also holds at the infinitesimal level. In the 3-dimensional case, however, a CR structure need not be embeddable.
Unlike in the embeddable case, it turns out that in the nonembeddable case there is an infinite-dimensional space of solutions to the linearized obstruction flatness equation on the standard CR 3-sphere and this space defines a natural complement to the tangent space of the embeddable deformations. In spite of this, we show that the CR 3-sphere does not admit nontrivial obstruction flat deformations, embeddable or nonembeddable.
Local-global principles for homogeneous spaces over some two-dimensional geometric global fields
Authors: Izquierdo Diego , Lucchini Arteche Giancarlo 
Published: October 2021

Abstract
In this article, we study the obstructions to the local-global principle for homogeneous spaces with connected or abelian stabilizers over finite extensions of the field

ℂ
⁢

(

(
x
,
y
)

)

{\mathbb{C}((x,y))}

of Laurent series in two variables over the complex numbers and over function fields of curves over

ℂ
⁢

(

(
t
)

)

{\mathbb{C}((t))}

. We give examples that prove that the Brauer–Manin obstruction with respect to the whole Brauer group is not enough to explain the failure of the local-global principle, and we then construct a variant of this obstruction using torsors under quasi-trivial tori which turns out to work. In the end of the article, we compare this new obstruction to the descent obstruction with respect to torsors under tori. For that purpose, we use a result on towers of torsors, that is of independent interest and therefore is proved in a separate appendix.
Construction of a class of maximal commutative subalgebras of prime Leavitt path algebras
Authors: Bajor Grzegorz , van Wyk Leon , Ziembowski Michał 
Published: October 2021

Abstract
Considering prime Leavitt path algebras

L
K

⁢

(
E
)

{L_{K}(E)}

, with E being an arbitrary graph with at least two vertices, and K being any field, we construct a class of maximal commutative subalgebras of

L
K

⁢

(
E
)

{L_{K}(E)}

such that, for every algebra A from this class, A has zero intersection with the commutative core

ℳ
K

⁢

(
E
)

{\mathcal{M}_{K}(E)}

of

L
K

⁢

(
E
)

{L_{K}(E)}

defined and studied in
[C. Gil Canto and A. Nasr-Isfahani,
The commutative core of a Leavitt path algebra,
J. Algebra 511 2018, 227–248].
We also give a new proof of the maximality, as a commutative subalgebra, of the commutative core

ℳ
R

⁢

(
E
)

{\mathcal{M}_{R}(E)}

of an arbitrary Leavitt path algebra

L
R

⁢

(
E
)

{L_{R}(E)}

, where E is an arbitrary graph and R is a commutative unital ring.
Sequence stratigraphy and coal accumulation model of the Taiyuan Formation in the Tashan Mine, Datong Basin, China
Authors: Duan Hongyue , Xie Weidong , Zhao Jianguang , Jia Tengfei 
Published: October 2021

Abstract
Datong Basin is a platform uplift formed in the Cenozoic era and has a significant coal-bearing geological unit in China. Tashan Mine is located in the middle-eastern part of the Datong Basin, the coal resources of the Taiyuan Formation are abundant, and the research value is enormous. Of the coal resources, coal seams 3–5 and 8 are the main. The lack of research in sequence stratigraphy, coal-forming environment, coal-accumulating model limits the layout efficiency of working face and the exploration and development efficiency of coal measures associated resources. This study used sedimentary and sequence stratigraphy and calculated and measured field drilling data to investigate the sequence stratigraphic characteristics, paleogeographic pattern, and coal accumulation model of the Taiyuan Formation. The sequence boundary and system tract boundary were identified, and the Taiyuan Formation was divided into four third-order sequences. The paleogeographic pattern was reconstructed with the third-order sequence as a unit by applying the single-factor analysis and multifactor comprehensive mapping. Additionally, the distribution characteristics of the main coal seams were clarified, and the corresponding coal accumulation model was reconstructed. The results exhibit that the sedimentary facies transformed from carbonate platform–tidal flat–lagoon–shallow water delta facies to shallow water delta facies from SQ1 to SQ2, coal seam 8 formed in interdistributary bay microfacies and peat swamp microfacies in SQ1. Transgression further expanded in SQ3, and the sedimentary facies were still dominated by the shallow water delta facies. Coal seams 3–5 are formed in distributary channel microfacies, which consist of interdistributary bay microfacies and peat swamp microfacies. The paleogeographic pattern was still dominated by shallow water delta in SQ4, in which interdistributary depressions and peat swamp microfacies widely developed. The thickness of coal seams 3–5 is in the range of 2.40–25.90 m, in which the northwestern study area is characterized by moderate water depth and sufficient fine sediment, and the widely developed distributary bay and peat swamp deposited a thick coal seam. The thickness of coal seam 8 is in the range of 0.5–10.5 m, and the thickness is stable (mostly thicker than 6 m) controlled by the widely developed lagoon, mud flat, and peat swamp microfacies and reduction water environment.
Philosophical presentation and the implicitly humorous structure of philosophy
Authors: Barris Jeremy 
Published: October 2021

Abstract
Philosophy often at least implicitly includes and depends on a logical structure which is also that of jokes. This is the case when philosophy involves questioning or establishing concepts in their own right, and when it involves the kinds of metaphysics which ask about reality and the world as a whole or as such. Taking this humour-like structure into account in presenting philosophy helps, among other things, to lay open part of the character of philosophy itself, to underscore the radical self-perspective that is constitutive of philosophy, and to contextualise the often confusing experience of coming to grips with an unfamiliar philosophical framework.
Expert vs. influencer: Philosophy presented under conditions of second-order observation
Authors: Moeller Hans-Georg , O’neill Rory , Fai Chiang Hio 
Published: October 2021

Abstract
Philosophy is presented in a wide range of forms, none of which can be convincingly claimed to be the “genuine” one. Historically speaking, there is not one “proper” way of doing philosophy, evidencing what may be called the social contingency of philosophy. This paper aims to provide a “critical” philosophy of today, in the Kantian sense of a philosophy that reflects on the conditions of its possibility, and thereby acknowledges the limitations they impose. Conceptually, our approach is grounded in Niklas Luhmann’s social systems theory, in which “functional differentiation” and “second-order observation” are two crucial characteristics of modern society. The paper discusses how presentations of philosophy align themselves with the second-order observation mechanisms of the specific social systems in which they are “hosted.” This paper deals in particular with two such systems: academics and social (or mass) media. These forms of presenting philosophy produce two different kinds of philosophy presenters: the expert and the influencer.
Anisotropy in tensile behavior of an extruded Mg-4.50Zn-1.13Ca (wt.%) alloy
Authors: Du Yuzhou , Zheng Mingyi , Ge Yanfeng , Jiang Bailing 
Published: October 2021

Abstract
The present study investigated anisotropy in tensile behavior of an extruded Mg-4.50Zn-1.13Ca (wt.%) alloy through tensile testing along different tilt angles relative to the extrusion direction. Results showed that the as-extruded Mg-4.50Zn-1.13Ca (wt.%) alloy exhibited anisotropy in tensile behavior due to the formation of basal texture. Basal slip, prismatic slip and tensile twinning were the dominant deformation modes depending on the tensile direction. Prismatic slip was the dominant deformation mode for samples with small tilt angle (θ = 0° and 22.5°). Basal slip was activated when the tilt angle was increased, which also resulted in the decrease of yield strength. Tensile twinning was responsible for the yielding of the samples with high tilt angles (θ = 67.5° and 90°). The ductility was significantly reduced at high tilt angle, which was mainly attributed to the appearance of tensile twinning during tensile deformation.
Solvothermal synthesis and characterization of well-dispersed cerium-doped Y2SiO5 phosphor particles
Authors: Li Xianxue 
Published: October 2021

Abstract
Well-dispersed cerium-doped Y2SiO5 (Ce:YSO) phosphor particles with spherical morphology and good luminescence intensity have been achieved by a solvothermal method with ethanol and water as solvent media. X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence spectrophotometry and transmission electron microscopy were employed to characterize the as-synthesized Ce:YSO precursor and powders. The results showed that pure-phase Ce:YSO powders with a mean particle size of about 162 nm were accurately available at 310°C and above. The fluorescence ability and persistent luminescence decay properties of the Ce:YSO powders were also studied, and the excellent fluorescence properties could be attributed to the homogeneous Ce:YSO particles obtained through the solvothermal method.
Effect of phosphorus on the density and molar volume of Al–Si alloy without solidification shrinkage
Authors: Dang Bo , Jian Zengyun , Xu Junfeng 
Published: October 2021

Abstract
The Al–Si alloys exhibit many unique properties, but not enough work has been dedicated to their thermophysical properties. In this work, the effect of phosphorus modifier on the density, molar volume and solidification shrinkage rate of Al-25% Si alloys was investigated by using the indirect Archimedes method. The results show that both density–temperature and molar volume–temperature curves show three inflection points: the liquidus temperature point, the eutectic transformation starting point and the finishing point. The density of the solidus linearly decreases and that of the liquidus linearly increases with phosphorus modifier content. Compared with Vegard’s law, the molar volumes show a negative deviation. Finally, the solidification shrinkage rate is calculated from the densities of solidus and liquidus.