bluuebunny/crossref_metadata_2025_split huggingface dataset:
HOARSENESS OF VOICE: ETIOLOGICAL SPECTRUM
Authors: Vaishnav Jairaj Kumar 
Published: August 2021

Background: To evaluate the etiological factors of hoarness
Methods: The present study has been carried out in 100 cases of hoarseness were included. Patient with laryngeal and hypopharyngeal malignancy & up to 15 year of age excluded from the study.
Results: In the present series bronchogenic carcinoma is the most common etiological factor causing vocal cord paralysis and second is thyroid surgery and third is tuberculosis of lung
Conclusion: Voice production is a complex mechanism, involving the muscles of pharynx, palate, tongue, nose and lips. A proper protocol is necessary for identifying the factors responsible for vocal fold paralysis which would help in managing the condition more effectively.
Keywords: Vocal cord, Carcinoma, Paralysis.
MICROBIOLOGICAL PROFILE OF CHRONIC TONSILLITIS IN THE PEDIATRIC AGE GROUP
Authors: Vaishnav Jairaj Kumar 
Published: August 2021

Background: The paediatric age group is more prone to tonsillitis. The management of tonsillitis mainly based on understanding of microbiological and pathological features. This study aimed to discuss the microbiological profile of acute tonsillitis in children.
Methods: Children fewer than 18 years age group was included in this study and the children underwent tonsillectomy or in antibiotics for at least one month were excluded from study. The throat swabs were taken for microbiological diagnosis.
Results: The most common isolates were Streptococcus viridians group, Group A ?-hemolytic Streptococci. There were only 3 cases with polymicrobial growth
Conclusions: The understanding of microbiological profile could help in management of acute tonsillitis. The pathological profile can help us to identify the organisms which are difficult to culture.
Keywords: Acute tonsillitis, Bacteria, Profile
Adiposidad corporal y resistencia muscular abdominal en jóvenes con síndrome de Down
Authors: Pino Marcelo , Muñoz Fernando , Henríquez Matías , Luarte Rocha Cristian , Gomez Campos Rossana , Cossio Bolaños Marco , Castelli de Campos Luis Felipe 
Published: August 2021

Objetivo: verificar la relación entre la resistencia muscular abdominal y la adiposidad corporal medido por el indice cintura-estatura en jóvenes con síndrome de Down (SD).Pacientes y Método: Estudio descriptivo comparativo en 115 jóvenes con SD, 65 varones, rango de edad 10 a 18 años, provenientes de la región del Maule. Se evaluó el peso, la estatura y la circunferencia de la cintura. Se calculó el índice de masa corporal (IMC) y el índice de cintura-estatura (ICE). Se evaluó la prueba de resistencia muscular abdominal (RMA) en 60 segundos y se clasificó en dos categorías (bajo RMA y aceptable RMA). Resultados: En ambos sexos los participantes clasificados con adecuados niveles de RMA presentaron menores valores de ICE e IMC (p < 0,05), mientras que los clasificados con bajo nivel de RMA evidenciaron elevados valores de ICE e IMC (p < 0,05). Las correlaciones entre adiposidad y RMA fueron negativas y oscilaron en ambos sexos entre r = -0,20 a -0,25, p < 0,05.Conclusiones: El estudio demostró que los jóvenes de ambos sexos con SD clasificados con niveles adecuados de RMA, presentaron valores disminuidos de ICE.
JAVANESE TRADITIONAL ART-DANCE AS THE IMPLEMENTATION OF CHARACTER EDUCATION OF CHILDREN TO SUPPORT CHILD FRIENDLY SCHOOL
Authors: Supeni Siti 
Published: August 2021

The purpose of the research is to: ( I) identify character education of children in various Javanese traditional dances, (2) to analyze the needs, output, problems. and learning objectives of child-friendly schools (CFS) in applying character education based on regional dance by interviewing a dancer trainer and a professional dancer who have experiences in creating and practicing the dances, and (3) to identify types of Javanese traditional dance values inside the dances. the types of research is through literary studies, interviews, surveys, observations, and documentation. To analyze the data, the researchers useResearch & Development. The findings show that (1) identification of charactereducation in various Javanese traditional dance, (2) there are the needs, output, problems, and learning objectives of child-friendly schools (CFS) in implementing character education based on regional dance, and (3) types of Javanese traditional dance values from.
Keywords: Javanese Traditional Dance, Character Education, Child-Friendly School
The Role of Educational Theory in the Future Development of Paramedicine as a Profession: An Integrative Review
Authors: Bell Andy , Hammer Sara , Seymour-Walsh Amy 
Published: August 2021

Introduction Paramedicine is at a critical juncture in its history as a healthcare profession. The evolution of paramedic practice in Australia over recent decades has culminated in its inclusion as a nationally registered, accredited, healthcare profession, while similar development is also occurring worldwide. Although paramedic education has developed over time, it is now the moment to determine whether existing educational approaches can adequately support its ongoing evolution as a profession. This article shares findings of a systematic, integrative review of characteristics of professions, allied health education and paramedic education literature. Methods Due to too little current research on approaches to paramedic education, the review aimed to distil essential requirements of professional education in general, and paramedic education in particular. This distillation served as an initial point of comparison with existing educational approaches in paramedicine. Literature was iteratively searched using PubMed, ScienceDirect and EBSCOhost megafile ultimate search engines, and was complemented with manual searches via professional networks, reference searches and Google Scholar. Results The literature review highlighted consistent themes relevant to paramedic education such as, the socio-political definition of a profession, methods for the identification of a profession, paramedicine as a distinct healthcare profession and the contemporary paramedic education framework. Conclusion Based on findings from this integrative review, we conclude that there is a potential misalignment between existing paramedic curricula and the educational scaffolding required to develop practicing paramedic professionals. We recommend further investigation of this potential misalignment as part of conceptualising an effective, quality, educational framework that is fit-for-purpose.
Molecular Profiling of Chilli Germplasm By Using SSR Marker
Authors: Haque MI , Ishtiaque S , Islam MM , Mujahidi TA , Rahim MA 
Published: August 2021

The molecular characterization of chilli germplasm was done based on estimation of genetic diversity among the germplasm by using SSR markers. Forty chilli germplasms were analyzed using eight SSR primers. The SSR primers produced 30 SSR loci with an average value of 3.75 alleles per SSR locus. The similarity index matrix ranged from zero to 2.74. Polymorphic information content (PIC) of the SSR primers ranged from 0.543 to 0.735 with an average value of 0.658. The highest number (five) of allele was observed in primer CAMS-647, whereas the primers CAMS-864, CAMS-880 and CAMS-885 showed lowest number (three) of allele. The smallest allele was found in case of primer CAMS- 236 (176 bp), while the longest allele was detected for the primer CAMS- 864 (288 bp). Based on similarity matrix using the un-weighed Pair Group Method of Arithmetic Means (UPGMA) dendrogram, chilli germplasms were grouped into four main clusters. SSR markers showed genetic variability in the studied chilli germplasm.
SAARC J. Agric., 19(1): 1-13 (2021)
THE SYMPTOMS AND CO-MORBIDITIES OF COVID-19 PATIENTS AT HOME ISOLATION IN INDIA
Authors: MURARKAR Sujata , MAHAJAN Sudhanshu , GOTHANKAR Jayashree 
Published: August 2021

Introduction: An Indian Government has issued the guidelines on home isolation for very mild/pre-symptomatic COVID-19 cases based on a proposal of the Directorate of Public Health and Preventive Medicine. This has originated when COVID-19 designated hospitals started to shift asymptomatic and stable patients to quarantine facilities to reserve beds for those in need of treatment.
Objectives: To determine the prevalence of symptoms and co-morbidities of COVID-19 positive patients at home isolation OPD.
Methods: This cross-sectional study was conducted at a designated COVID-19 tertiary care hospital in Pune, India, which had included all COVID-19 positive patients enrolled for the home isolation care from the 15th July to 15th August 2020.
Results: There were total 639 adults out of which 362 were males and 277 females. The most common presenting symptom present in 49.4% cases was fever. Hypertension was the most prevalent comorbidity noticed in 10% of patients followed by Diabetes in 6.7%. The maximum time lag of positive COVID-19 test to registration for home isolation OPD of 8 days was observed in only 1 patient. The significant association was seen between symptom of fever with the adults (males) and in the age group of 31-50 years(p
Respuestas cardiovasculares al ejercicio con un circuito funcional mediado por tecnología en estudiantes universitarios: estudio piloto
Authors: Vargas Pinilla Olga Cecilia , García-Salazar Luisa Fernanda , Alfonso Mantilla Jose Ivan 
Published: August 2021

Introducción: La tecnología basada en video juegos activos es una herramienta atractiva para la realización de actividad física, adicionar esta tecnología a un circuito funcional promueve la integración de estímulos visuales, audlitivos, propioceptivos y genera una respuesta aeróbica. Este estudio piloto tuvo como objetivo evaluar la respuesta cardiovascular de estudiantes universitarios, a través de un circuito que incluye actividades con X-box Kinect y Fitlight trainer™. Materiales y métodos: Estudio descriptivo, que incluyó, mediante convocatoria abierta, estudiantes de una institución universitaria entre 18 y 25 años, aparentemente sanos, quienes realizaron un circuito conformado por 4 estaciones, el cual repetían tres veces con un minuto de recuperación, para una duración total de 20 minutos. Se evaluaron las variables de frecuencia cardiaca (FC), esfuerzo percibido y porcentaje de la FC alcanzada con respecto a la FC máxima según Tanaka. Resultados: 13 participantes, 8 hombres y 5 mujeres, clasificados en activos y sedentarios, alcanzaron durante el entrenamiento niveles de intensidad moderada a alta, cercana a un 90% de la FC máxima; en cuanto al esfuerzo percibido ambos grupos clasificaron la actividad como “intensa”. Conclusiones: El circuito funcional propuesto estimula el umbral aeróbico en población activa y sedentaria. Esto puede estar relacionado con la alta intensidad manejada en el circuito en un corto periodo de tiempo, además de la exigencia muscular durante el uso de elementos virtuales como el X-box Kinect. Es posible generar programas de ejercicio con el uso de tecnología que sean novedosos y atractivos en la población joven, para reducir el sedentarismo.
Palabras clave: Entrenamiento de Intervalos de Alta Intensidad; Ejercicio en Circuitos; Realidad Virtual; Exergaming
Occupational Allergic Sensitization Among Workers Processing King Crab (Paralithodes camtschaticus) and Edible Crab (Cancer pagurus) in Norway and Identification of Novel Putative Allergenic Proteins
Authors: Thomassen Marte R. , Kamath Sandip D. , Bang Berit E. , Nugraha Roni , Nie Shuai , Williamson Nicholas A. , Lopata Andreas L. , Aasmoe Lisbeth 
Published: August 2021

Introduction: Asthma and allergy occur frequently among seafood processing workers, with the highest prevalence seen in the crustacean processing industry. In this study we established for the first time the prevalence of allergic sensitization in the Norwegian king- and edible crab processing industry and characterized the IgE-reactive proteins.Materials and Methods: Two populations of crab processing workers participated; 119 king crab and 65 edible crab workers. The investigation included information on work tasks and health through a detailed questionnaire. Allergic sensitization was investigated by crab-specific IgE quantification and skin prick tests (SPT) to four in-house prepared crab extracts; raw meat, cooked meat, raw intestines and raw shell. Allergen-specific IgE binding patterns were analyzed by IgE immunoblotting to the four allergen extracts using worker serum samples. Total proteins in crab SPT extracts and immunoblot-based IgE binding proteins were identified by mass spectrometric analysis.Results: Positive SPTs were established in 17.5% of king- and 18.1% of edible crab workers, while elevated IgE to crab were demonstrated in 8.9% of king- and 12.2% of edible crab processing workers. There was no significant difference between the king and edible crab workers with respect to self-reported respiratory symptoms, elevated specific IgE to crab or SPT results. Individual workers exhibited differential IgE binding patterns to different crab extracts, with most frequent binding to tropomyosin and arginine kinase and two novel IgE binding proteins, hemocyanin and enolase, identified as king- and edible crab allergens.Conclusions: Occupational exposure to king- and edible crabs may frequently cause IgE mediated allergic sensitization. Future investigations addressing the diagnostic value of crab allergens including tropomyosin and arginine kinase and the less well-known IgE-binding proteins hemocyanin and enolase in a component-resolved diagnostic approach to crab allergy should be encouraged.
Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients
Authors: Chauvin Manon , Larsen Martin , Quirant Bibiana , Quentric Paul , Dorgham Karim , Royer Luca , Vallet Hélène , Guihot Amelie , Combadière Béhazine , Combadière Christophe , Barallat Jaume , Mayaux Julien , Luyt Charles-Edouard , Mathian Alexis , Amoura Zahir , Boddaert Jacques , Armestar Fernando , Gorochov Guy , Martinez-Caceres Eva , Sauce Delphine 
Published: August 2021

HighlightsInnate immune activation during Covid-19 infection is associated with pernicious clinical outcome.BackgroundCoronavirus disease 2019 (Covid-19) is a worldwide threat that has already caused more than 3 000 000 deaths. It is characterized by different patterns of disease evolution depending on host factors among which old-age and pre-existing comorbidities play a detrimental role. Previous coronavirus epidemics, notably SARS-CoV, were associated with increased serum neopterin levels, which can be interpreted as a sign of acute innate immunity in response to viral infection. Here we hypothesize that neopterin may serve as a biomarker of SARS-CoV-2 viral infection and Covid-19 disease severity.MethodsWe measured neopterin blood levels by ELISA. Seric concentration was quantified from 256 healthy donors and 374 Covid-19 patients at hospital admission. Enrolled Covid-19 patients were all symptomatic and displayed a large spectrum of comorbidities. Patients were followed until disease resolution or death.ResultsSevere and critically ill SARS-CoV-2 infected patients were characterized by a profound exacerbation of immune activation characterized by elevated neopterin blood levels. Systemic neopterin levels above 19nM stratified healthy individuals from Covid-19 patients with 87% specificity and 100% sensitivity. Moreover, systemic neopterin levels above 53nM differentiated non-survivors from survivors with 64% specificity and 100% sensitivity.ConclusionWe propose that neopterin concentration measured at arrival to hospital is a hallmark of severe Covid-19 and identifies a high-risk population of pernicious clinical outcome with a need for special medical care.
Experimental Research on Compressive and Shrinkage Properties of ECC Containing Ceramic Wastes Under Different Curing Conditions
Authors: Xiong Yan , Yang Yi , Fang Shuai , Wu Di , Tang Yingfeng 
Published: August 2021

Engineered cementitious composites (ECCs) suffer from high shrinkage and low early strength due to large dosage of cementitious materials and slow hydration of fly ash. This study aims to improve compressive properties and reduce drying shrinkage of ECC using ceramic wastes and hydrothermal curing. Experimental results have indicated that ceramic polishing powder (CPP) and recycled ceramic sand (RCS) exert opposite effect on the compressive strength of ECC. Hydrothermal-cured ECC enhances elasticity modulus and compressive strength and reduces later drying shrinkage as compared with that under standard curing. A CPP dosage of 35% and a hydrothermal curing regime with a temperature of 70°C and age of 7 days are recommended for the engineering application of ECC.
Right Ventricular Function Predicts Adverse Clinical Outcomes in Patients With Chronic Thromboembolic Pulmonary Hypertension: A Three-Dimensional Echocardiographic Study
Authors: Li Yidan , Liang Lirong , Guo Dichen , Yang Yuanhua , Gong Juanni , Zhang Xinyuan , Zhang Di , Jiang Zhe , Lu Xiuzhang 
Published: August 2021

Background: Right ventricular (RV) function plays a vital role in the prognosis of patients with chronic thromboembolic pulmonary hypertension (CTEPH). We used new machine learning (ML)-based fully automated software to quantify RV function using three-dimensional echocardiography (3DE) to predict adverse clinical outcomes in CTEPH patients.Methods: A total of 151 consecutive CTEPH patients were registered in this prospective study between April 2015 and July 2019. New ML-based methods were used for data management, and quantitative analysis of RV volume and ejection fraction (RVEF) was performed offline. RV structural and functional parameters were recorded using 3DE. CTEPH was diagnosed using right heart catheterization, and 62 patients underwent cardiac magnetic resonance to assess right heart function. Adverse clinical outcomes were defined as PH-related hospitalization with hemoptysis or increased RV failure, including conditions requiring balloon pulmonary angioplasty or pulmonary endarterectomy, as well as death.Results: The median follow-up time was 19.7 months (interquartile range, 0.5–54 months). Among the 151 CTEPH patients, 72 experienced adverse clinical outcomes. Multivariate Cox proportional-hazard analysis showed that ML-based 3DE analysis of RVEF was a predictor of adverse clinical outcomes (hazard ratio, 1.576; 95% confidence interval (CI), 1.046~2.372; P = 0.030).Conclusions: The new ML-based 3DE algorithm is a promising technique for rapid 3D quantification of RV function in CTEPH patients.
Prolonged Use of Proton Pump Inhibitors, but Not Histamine-2 Receptor Antagonists, Is Associated With Lower Bone Mineral Density in Males Aged Over 70
Authors: Gao Shihua , Song Wenting , Lin Tianye , Chen Wenhuan , He Wei , Wei Qiushi , Li Ziqi 
Published: August 2021

Aims: The association of acid suppressants use with bone mineral density (BMD) is still unclear, especially in older adult with prolonged use of proton pump inhibitors (PPIs) or histamine-2 receptor antagonists (H2RAs). In this study, our aim was to investigate the association between PPI or H2RA use and BMD in general US older adults.Methods: We conducted a cross-sectional study on a sample from National Health and Nutrition Examination Survey. Association between long-term use of PPIs or H2RAs and lumber spine BMD in elderly was evaluated using weighted multivariate linear regression models. Sensitive and subgroup analysis were also performed in this study.Results: Long-term PPI use is correlated with lower lumber spine BMD in our multivariable regression model after adjusting for known confounding factors. Further analysis showed PPI use with a duration over 1 year was negatively associated with lumber spine BMD in male, elderly aged over 70 years, and white elderly. There is no significant association between long-term H2RA use and lumber spine BMD.Conclusions: Our results indicated that the association between long-term use of PPI and lumber spine BMD differed by gender. Long term use of PPIs would reduce lumber spine BMD in older men, while H2RA use is not significantly linked with lumber spine BMD. Patients that are at high risk of bone loss should shortened the duration of PPI use (&lt;1 year) or use H2RAs as alternative if possible.
Electrophysiological Screening for Children With Suspected Auditory Processing Disorder: A Systematic Review
Authors: Liu Panting , Zhu Huiqin , Chen Mingxia , Hong Qin , Chi Xia 
Published: August 2021

Objective:This research aimed to provide evidence for the early identification and intervention of children at risk for auditory processing disorder (APD). Electrophysiological studies on children with suspected APDs were systematically reviewed to understand the different electrophysiological characteristics of children with suspected APDs.Methods:Computerized databases such as PubMed, Cochrane, MEDLINE, Web of Science, and EMBASE were searched for retrieval of articles since the establishment of the database through May 18, 2020. Cohort, case-control, and cross-sectional studies that evaluated the literature for the electrophysiological assessment of children with suspected APD were independently reviewed by two researchers for literature screening, literature quality assessment, and data extraction. The Newcastle–Ottawa Scale and 11 entries recommended by the Agency for Healthcare Research and Quality were used to evaluate the quality of the literature.Results:In accordance with the inclusion criteria, 14 articles were included. These articles involved 7 electrophysiological testing techniques: click-evoked auditory brainstem responses, frequency-following responses, the binaural interaction component of the auditory brainstem responses, the middle-latency response, cortical auditory evoked potential, mismatch negativity, and P300. The literature quality was considered moderate.Conclusions:Auditory electrophysiological testing can be used for the characteristic identification of children with suspected APD; however, the value of various electrophysiological testing methods for screening children with suspected APD requires further study.
Vagus Nerve Stimulation Induced Motor Map Plasticity Does Not Require Cortical Dopamine
Authors: Brougher Jackson , Sanchez Camilo A. , Aziz Umaymah S. , Gove Kiree F. , Thorn Catherine A. 
Published: August 2021

Background: Vagus nerve stimulation (VNS) paired with motor rehabilitation is an emerging therapeutic strategy to enhance functional recovery after neural injuries such as stroke. Training-paired VNS drives significant neuroplasticity within the motor cortex (M1), which is thought to underlie the therapeutic effects of VNS. Though the mechanisms are not fully understood, VNS-induced cortical plasticity is known to depend on intact signaling from multiple neuromodulatory nuclei that innervate M1. Cortical dopamine (DA) plays a key role in mediating M1 synaptic plasticity and is critical for motor skill acquisition, but whether cortical DA contributes to VNS efficacy has not been tested.Objective: To determine the impact of cortical DA depletion on VNS-induced cortical plasticity.Methods: Rats were trained on a skilled reaching lever press task prior to implantation of VNS electrodes and 6-hydroxydopamine (6-OHDA) mediated DA depletion in M1. Rats then underwent training-paired VNS treatment, followed by cortical motor mapping and lesion validation.Results: In both intact and DA-depleted rats, VNS significantly increased the motor map representation of task-relevant proximal forelimb musculature and reduced task-irrelevant distal forelimb representations. VNS also significantly increased tyrosine hydroxylase (TH+) fiber density in intact M1, but this effect was not observed in lesioned hemispheres.Conclusion: Our results reveal that though VNS likely upregulates catecholaminergic signaling in intact motor cortices, DA itself is not required for VNS-induced plasticity to occur. As DA is known to critically support M1 plasticity during skill acquisition, our findings suggest that VNS may engage a unique set of neuromodulatory signaling pathways to promote neocortical plasticity.