bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of OCT–derived net corneal astigmatism measurement
Authors: Llorens-Quintana Clara , Pavlatos Elias , Thaware Omkar , Gupta Seema , Gradin Daniel , Romfh Denzil , Li Yan , Huang David 
Published: July 2021

Purpose:
To assess the repeatability and accuracy of corneal astigmatism measurement with a spectral-domain optical coherence tomography (OCT) system (Avanti, Optovue) and compare them with Scheimpflug imaging (Pentacam HR, Oculus) and swept-source optical biometry (IOLMaster 700, Carl Zeiss Meditec AG).

Setting:
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.

Design:
Prospective cross-sectional observational study.

Methods:
60 pseudophakic eyes with monofocal nontoric intraocular lens that previously had refractive surgery were analyzed. To assess accuracy, simulated keratometry (SimK) and net corneal astigmatism, obtained from each device, were compared with subjective manifest refraction astigmatism. Repeatability for corneal astigmatism was assessed for OCT and Pentacam HR by the coefficient of repeatability from 3 repeated measures.

Results:
Compared with manifest refraction, SimK readings produced with-the-rule astigmatic bias that was reduced for net astigmatism for the 3 devices. Except for OCT net astigmatism, all instruments significantly overestimated the magnitude of the astigmatism (linear mixed-effects model [LMM], P < .05). OCT net astigmatism showed the highest accuracy for manifest astigmatism prediction with the smaller 95% confidence ellipse for the mean difference vector. OCT net mean absolute difference was 0.57 diopters (D), significantly smaller than that of the other modalities (LMM, P < .05). Net corneal astigmatism measured with OCT showed the best repeatability (coefficient of repeatability = 0.29 D).

Conclusions:
OCT has the capability to measure net corneal astigmatism with higher precision and accuracy than Pentacam HR Scheimpflug imaging and IOLMaster 700 swept-source optical biometry in postrefractive subjects.
Protein arginine methyltransferase 7 modulates neuronal excitability by interacting with NaV1.9
Authors: Ma Tingbin , Li Lulu , Chen Rui , Yang Luyao , Sun Hao , Du Shiyue , Xu Xuan , Cao Zhijian , Zhang Xianwei , Zhang Luoying , Shi Xiaoliu , Liu Jing Yu 
Published: July 2021

Abstract
Human NaV1.9 (hNaV1.9), encoded by SCN11A, is preferentially expressed in nociceptors, and its mutations have been linked to pain disorders. NaV1.9 could be a promising drug target for pain relief. However, the modulation of NaV1.9 activity has remained elusive. Here, we identified a new candidate NaV1.9-interacting partner, protein arginine methyltransferase 7 (PRMT7). Whole-cell voltage-clamp recordings showed that coelectroporation of human SCN11A and PRMT7 in dorsal root ganglion (DRG) neurons of Scn11a
−/− mice increased the hNaV1.9 current density. By contrast, a PRMT7 inhibitor (DS-437) reduced mNaV1.9 currents in Scn11a
+/+ mice. Using the reporter molecule CD4, we observed an increased distribution of hLoop1 on the cell surface of PRMT7-overexpressing HKE293T cells. Furthermore, we found that PRMT7 mainly binds to residues 563 to 566 within the first intracellular loop of hNaV1.9 (hLoop1) and methylates hLoop1 at arginine residue 519. Moreover, overexpression of PRMT7 increased the number of action potential fired in DRG neurons of Scn11a
+/+ mice but not Scn11a
−/− mice. However, DS-437 significantly inhibited the action potential frequency of DRG neurons and relieved pain hypersensitivity in Scn11a
A796G/A796G mice. In summary, our observations revealed that PRMT7 modulates neuronal excitability by regulating NaV1.9 currents, which may provide a potential method for pain treatment.
Diversity of inhibitory and excitatory parvalbumin interneuron circuits in the dorsal horn
Authors: Gradwell Mark A. , Boyle Kieran A. , Browne Tyler J. , Bell Andrew M. , Leonardo Jacklyn , Peralta Reyes Fernanda S. , Dickie Allen C. , Smith Kelly M. , Callister Robert J. , Dayas Christopher V. , Hughes David I. , Graham Brett A. 
Published: July 2021

Abstract
Parvalbumin-expressing interneurons (PVINs) in the spinal dorsal horn are found primarily in laminae II inner and III. Inhibitory PVINs play an important role in segregating innocuous tactile input from pain-processing circuits through presynaptic inhibition of myelinated low-threshold mechanoreceptors and postsynaptic inhibition of distinct spinal circuits. By comparison, relatively little is known of the role of excitatory PVINs (ePVINs) in sensory processing. Here, we use neuroanatomical and optogenetic approaches to show that ePVINs comprise a larger proportion of the PVIN population than previously reported and that both ePVIN and inhibitory PVIN populations form synaptic connections among (and between) themselves. We find that these cells contribute to neuronal networks that influence activity within several functionally distinct circuits and that aberrant activity of ePVINs under pathological conditions is well placed to contribute to the development of mechanical hypersensitivity.
Topical Review: Perceptual-cognitive Skills, Methods, and Skill-based Comparisons in Interceptive Sports
Authors: Hodges Nicola J. , Wyder-Hodge Pearson A. , Hetherington Shawn , Baker Joseph , Besler Zachary , Spering Miriam 
Published: July 2021

SIGNIFICANCE
We give a comprehensive picture of perceptual-cognitive (PC) skills that could contribute to performance in interceptive sports. Both visual skills that are low level and unlikely influenced by experience and higher-level cognitive-attentional skills are considered, informing practitioners for identification and training and alerting researchers to gaps in the literature.
Perceptual-cognitive skills and abilities are keys to success in interceptive sports. The interest in identifying which skills and abilities underpin success and hence should be selected and developed is likely going to grow as technologies for skill testing and training continue to advance. Many different methods and measures have been applied to the study of PC skills in the research laboratory and in the field, and research findings across studies have often been inconsistent. In this article, we provide definitional clarity regarding whether a skill is primarily visual attentional (ranging from fundamental/low-level skills to high-level skills) or cognitive. We review those skills that have been studied using sport-specific stimuli or tests, such as postural cue anticipation in baseball, as well as those that are mostly devoid of sport context, considered general skills, such as dynamic visual acuity. In addition to detailing the PC skills and associated methods, we provide an accompanying table of published research since 1995, highlighting studies (for various skills and sports) that have and have not differentiated across skill groups.
Poorer Muscle Quality and Quantity With ART Initiation Is Associated With Greater Inflammation and Immune Activation
Authors: Kousari Arianna , Moser Carlee , Olefsky Maxine , Brown Todd T. , Currier Judith S. , McComsey Grace A. , Scherzinger Ann , Stein James H. , Lake Jordan E. , Erlandson Kristine M. 
Published: July 2021

Background:
We have previously shown that the initiation of antiretroviral therapy (ART) is associated with a decrease in skeletal muscle density (greater fat accumulation), suggesting that gains in lean body mass seen in many ART studies may reflect gains in low quality, fatty muscle. Here, we explore whether skeletal muscle density and area are associated with markers of inflammation and immune activation.

Methods:
ART-naïve people with HIV were randomized to raltegravir or ritonavir-boosted atazanavir or darunavir, each with tenofovir disoproxil fumarate/emtricitabine. Abdominal computed tomography scans from baseline and week 96 were reanalyzed for psoas density and area and correlations explored with inflammation [interleukin-6 (IL-6) and high-sensitivity C-reactive protein] and immune activation [soluble CD14 (sCD14), soluble CD163 (sCD163), and %CD38+HLADR+ on CD4+ or CD8+ T cells].

Results:
Two hundred twenty-two participants had available inflammation/immune activation markers and paired computed tomography scans. At baseline, lower psoas density (greater fat) correlated with higher IL-6 (r = −0.26, P < 0.001) and sCD163 (r −0.15, P = 0.03) and lower lean psoas area correlated with higher IL-6, high-sensitivity C-reactive protein, sCD14, sCD163, and %CD38+HLADR+ on CD4+ T cells (r = −0.30–0.13; all P ≤ 0.05). From baseline to week 96, greater percent decrease in total psoas density (more fat) correlated with greater increase in IL-6 (r = −0.14; P = 0.04); greater % decrease in lean psoas area correlated greater increases in IL-6, sCD14, sCD163, and %CD38+HLADR+ on CD8+ T cells (r = −0.15 to −0.18; all P < 0.04).

Conclusions:
Greater fat infiltration within the psoas muscle (lower density) and greater loss in lean psoas muscle area were associated with higher inflammation and immune activation, which may portend important effects on muscle function and cardiometabolic risk.
The Impact of Hospitalist Switch Day on Length of Stay
Authors: Yang Evan , Zhou Zhipeng , Walker Rebekah J. , Segon Yogita , Segon Ankur 
Published: July 2021

Background and Objective:
Hospitalist practices around the country switch service on different days of the week. It is unclear whether switching clinical service later in the week is associated with an increase in length of stay (LOS). The aim of this study was to examine the association between service switch day for hospitalists at an academic medical center and LOS.

Methods:
A single-center, cross-sectional study examined 4284 discharges from hospitalist staffed general internal medicine ward teams over a 1-year period between July 2018 and June 2019. Hospitalist service switch day changed from Tuesday to Thursday on January 1, 2019. The period between July 1, 2018, and December 31, 2018, was defined as the pre-switch time, while January 1, 2019, to June 30, 2019, was defined as the post-switch period. We calculated the LOS in days for patients discharged from hospitalist general internal medicine teams in the 2 periods. Generalized linear models were used to examine the association between attending switch day and LOS while adjusting for demographic factors, payer status, markers of severity of illness, and hospital or discharge-level confounders.

Results:
There was no difference in mean LOS for patients discharged in the pre-switch time (6 days) period versus patients discharged in the post-switch time (6.03 days) (difference of means 0.03 days, 95% confidence interval −0.04 to 0.09, P value .37).

Conclusions:
Change in attending switch day from earlier in the week to later in the week is not associated with an increase in LOS. Other factors such as group preference and institutional needs should drive service switch day selection for hospitalist groups.
Data Analysis and Forecasting of COVID-19 Pandemic in Kuwait
Authors: Oshinubi Kayode , Al-Awadhi Fahimah , Rachdi Mustapha , Demongeot Jacques 
Published: July 2021

AbstractThe first COVID 19 case of Kuwait was announced on 24th February, 2020 and the daily new cases increases exponentially since then until May, 2020 when the first wave started to decline. The same exponential dynamics has been observed between January and March, 2021. The forecast of new cases and death recorded daily is crucial so that health experts and citizens can be guided in order to avoid escalation of the pandemic. We propose a deterministic method to predict the basic reproduction number Ro of first and second wave of COVID-19 cases in Kuwait and also to forecast the daily new cases and death of the pandemic in the country. Forecasting has been done using ARIMA model, Exponential smoothing model, Holts’ method, Prophet forecasting model and machine learning models like log-linear, polynomial and support vector regressions. The results presented aligned with other methods used to predict Ro in first and second waves and the forecasting clearly shows the trend of the pandemic in Kuwait. The deterministic prediction of Ro is a good forecasting tool available during the exponential phase of the contagion, which shows an increasing trend during the beginning of the first and second waves of the pandemic in Kuwait.
Vimentin Intermediate Filaments and Filamentous Actin Form Unexpected Interpenetrating Networks That Redefine the Cell Cortex
Authors: Wu Huayin , Shen Yinan , Sivagurunathan Suganya , Weber Miriam Sarah , Adam Stephen A. , Shin Jennifer H. , Fredberg Jeffrey J. , Medalia Ohad , Goldman Robert , Weitz David A. 
Published: July 2021

AbstractVimentin intermediate filaments (VIFs) and F-actin are filamentous cytoskeletal proteins generally thought to form completely independent networks that have vastly different properties and functions. Here, we show that, unexpectedly, there exist both extensive structural and functional interactions between VIFs and F-actin. We show that VIFs and F-actin form an interpenetrating network (IPN) within the cell cortex and interact synergistically at multiple length scales. This IPN structure has important functional consequences in cells: The IPN results in enhanced contractile forces in the cell. In addition, VIFs influence the diffusive behavior of actin monomers, suggesting specific associations between actin and vimentin proteins in the cytoplasm; this facilitates formation of the IPN and has downstream effects on other actin-driven processes. The results suggest that contributions of VIFs and F-actin are strongly correlated. Such interactions counter generally accepted behavior and are broadly significant given the wide range of processes currently attributed to F-actin alone.
The HMCES DNA-protein cross-link functions as a constitutive DNA repair intermediate
Authors: Semlow Daniel R. , MacKrell Victoria A. , Walter Johannes C. 
Published: July 2021

AbstractThe HMCES protein forms a covalent DNA-protein cross-link (DPC) with abasic (AP) sites in ssDNA, and the resulting HMCES-DPC is thought to suppress double-strand break formation in S phase. However, the dynamics of HMCES cross-linking and whether any DNA repair pathways normally include an HMCES-DPC intermediate remain unknown. Here, we show that an HMCES-DPC forms efficiently on the AP site generated during replication-coupled DNA interstrand cross-link (ICL) repair. We use this system to show that HMCES cross-links form on DNA after the replicative CMG helicase has passed over the AP site, and that HMCES is subsequently removed by the SPRTN protease. The HMCES-DPC suppresses DSB formation, slows translesion synthesis (TLS) past the AP site, and introduces a bias for insertion of deoxyguanosine opposite the AP site. These data show that HMCES-DPCs can form as constitutive intermediates in replication-coupled repair, and they suggest a general model of how HMCES protects AP sites during DNA replication.
Antibiotic treatment induces activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus
Authors: Çalışkan Gürsel , French Timothy , Heimesaat Markus M. , Dunay Ildiko Rita , Stork Oliver 
Published: July 2021

AbstractAntibiotics are widely applied for the treatment of bacterial infections, but their long-term use may lead to gut flora dysbiosis and detrimental effects on brain physiology, behavior as well as cognitive performance. Still, a striking lack of knowledge exists concerning electrophysiological correlates of antibiotic-induced changes in gut microbiota and behavior. Here, we investigated changes in the synaptic transmission and plasticity together with behaviorally-relevant network activities from the hippocampus of antibiotic-treated mice. The prolonged antibiotic treatment led to a strong reduction of myeloid cell pools in bone marrow, circulation and those surveilling the brain. Upon antibiotic treatment, circulating Ly6Chi inflammatory monocytes adopted a proinflammatory phenotype with increased expression of CD40 and MHC II. In the central nervous system, microglia displayed typical signs of activation with elevated CD40 and MHC II expression, as well as increased IL-6 and TNF production. Concomitantly, we detected a substantial reduction in the synaptic transmission in the hippocampal CA1 after antibiotic treatment. In line, carbachol-induced cholinergic gamma oscillation were reduced upon antibiotic treatment while the incidence of hippocampal sharp waves was elevated. These changes were associated with the global changes in the expression of neurotrophin nerve growth factor and inducible nitric oxide synthase, both of which have been shown to influence cholinergic functions. Overall, our study demonstrates that antibiotic-induced changes in the gut microbiome and immune cell function are associated with a drastic reduction in the synaptic transmission and gamma oscillations in the hippocampus, a brain region that is critically involved in mediation of innate and cognitive behavior.
An active force controlled of small CMG-based satellite
Authors: Salleh Mohd Badrul , Mohd Suhadis Nurulasikin , Varatharajoo Renuganth 
Published: July 2021

Purpose
This paper aims to investigate the attitude control pointing improvement for a small satellite with control moment gyroscopes (CMGs) using the active force control (AFC) method.

Design/methodology/approach
The AFC method is developed with its governing equations and integrated into the conventional proportional-derivative (PD) controller of a closed-loop satellite attitude control system. Two numerical simulations of an identical attitude control mission namely the PD controller and the PD+AFC controller were carried out using the MATLAB®-SimulinkTM software and their attitude control performances were demonstrated accordingly.

Findings
Having the PD+AFC controller, the attitude maneuver can be completed within the desired slew rate, which is about 2.14 degree/s and the attitude pointing accuracies for the roll, pitch and yaw angles have improved significantly by more than 85% in comparison with the PD controller alone. Moreover, the implementation of the AFC into the conventional PD controller does not cause significant difference on the physical structure of the four single gimbal CMGs (4-SGCMGs).

Practical implications
To achieve a precise attitude pointing mission, the AFC method can be applied directly to the existing conventional PD attitude control system of a CMG-based satellite. In this case, the AFC is indeed the backbone for the satellite attitude performance improvement.

Originality/value
The present study demonstrates that the attitude pointing of a small satellite with CMGs is improved through the implementation of the AFC scheme into the PD controller.
Membrane mode enhanced cohesive zone element
Authors: Töller Felix , Löhnert Stefan , Wriggers Peter 
Published: July 2021

PurposeIn certain cases, traction–separation laws do not reflect the behaviour sufficiently so that thin volumetric elements, Internal Thickness Extrapolation formulations, bulk material projections or various other approaches are applied. All of them have disadvantages in the formulation or practical application.Design/methodology/approachDamage within thin layers is often modelled using at cohesive zone elements (CZE). The constitutive behaviour of cohesive zone elements is usually described by traction–seperation laws (TSLs) that consider the (traction separation) relation in normal opening and tangential shearing direction. Here, the deformation (separation) as well as the reaction (traction) are vectorial quantities.FindingsIn this contribution, a CZE is presented that includes damage from membrane modes.Originality/valueMembrane mode-related damaging effects that can be seen in physical tests that could not be simulated with standard CZEs are well captured by membrane mode–enhanced cohesive zone elements.
Understanding employees' innovative work behavior through interactionist perspective: the effects of working style, supportive noncontrolling supervision and job complexity
Authors: Al-Ghazali Basheer M. 
Published: July 2021

PurposeThis study extends the actor–context interactionist model of individual innovation from the traditional synergetic pattern to a complementary one. The complementary perspective emphasizes the need for integration of divergence and convergence in enhancing employee's innovative work behavior. This study examines how individual working style relates to innovative work behavior through supportive noncontrolling supervision and job complexity.Design/methodology/approachThe study used a time-lagged research design, collecting data through surveys from 262 employees and their immediate supervisors working in telecommunication companies of Saudi Arabia.FindingsThis study found that (1) employee with an intuitively inclined working style (e.g. a divergent predictor) engages in higher levels of innovative work behavior when supportive noncontrolling supervision or job complexity (e.g. convergent factors) is higher; and (2) the positive interactive effect of intuitive working style and supportive noncontrolling supervision on employee's innovative work behavior is stronger when job complexity is higher rather than lower.Originality/valueThis study provides deeper understanding of the interactionist perspective of employees' innovative work behavior. This study is the first of its kind to integrate complementary and synergistic perspectives of actor–context interactionist model of employees' innovative work behavior.
A qualitative exploration of post-migration stressors and psychosocial well-being in two asylum reception centres in Belgium
Authors: Whitehouse Katherine , Lambe Ella , Rodriguez Sofia , Pellecchia Umberto , Ponthieu Aurelie , Van den Bergh Rafael , Besselink Djoen 
Published: July 2021

PurposeProlonged exposure to daily stressors can have long-term detrimental implications for overall mental health. For asylum seekers in European Union transit or destination countries, navigating life in reception centres can represent a significant burden. The purpose of this study was to explore post-migration stressors during residency in reception centres, and to formulate recommendations for adequate service provision in Belgium.Design/methodology/approachResearch was conducted in two reception centres in Belgium. A total of 41 in-depth interviews were carried out with asylum seeker residents (n= 29) and staff (n= 12). Purposive recruitment was used for asylum seekers (for variation in length of centre residency and family status) and staff (variation in job profiles). Interviews were conducted in English, French or with a translator in Arabic or Dari. Interviews were audio-recorded, transcribed verbatim and manually coded using thematic analysis.FindingsAsylum seekers face significant constraints with regard to their living conditions, including total absence of privacy, overcrowding and unhygienic conditions. These act as continuous and prolonged exposure to daily stressors. Several barriers to accessing activities or integration opportunities prevent meaningful occupation, contribute towards eroded autonomy and isolation of asylum seeker residents. Inadequate capacity and resources for the provision of psychosocial support in reception centres leads to a sense of abandonment and worthlessness.Originality/valueAnalysis indicates that structural and practical challenges to adequately support asylum seekers are rooted in policy failures necessary for appropriate resourcing and prioritization of preventative measures. Such deliberate decisions contribute towards state deterrence strategies, eroding both individual well-being and manufacturing a crisis in the systems of support for asylum seekers.