bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Shell-type Self-assembled Mineralized Adsorbent for Hg(II) Absorption: Synthesis and Performance Studies
Authors: Peng Yang , Zhang Chuxuan , Li Xiaomin , Feng Tianyi , Gong Xun 
Published: October 2021

Abstract
For forming adsorbents, the stability of cyclic adsorption is as important as the adsorption properties. In this work, A shell-type self-assembled mineralized adsorbent based on Ca-alginate was synthesized for Hg(II) adsorption. The synthesis process consists of gelation of Ca-based spherical polymer template (CAB) and rate-controlled self-assembly mineralization in bicarbonate solution. A shell-type porous crystal layer is proved to be formed on the surface of the organic polymer template by rate-controlled self-assembly mineralization. The single-factor experiment demonstrates that 1% (MCAB-1) is the optimal concentration of bicarbonate. A maximum adsorption capacity, 48 ± 4 mg/g of MCAB-1 was observed at a pH = 5 in batch test, which was 2.67 times that of the unmodified one, CAB, 18 ± 1 mg/g. Long duration (10 h) adsorption tests showed that MCAB-1 exhibited remarkable performance stability and anti-wear ability (43.2 % removal efficiency and 74.3 % mass retention, compared to 2.7 % and 38.6 % of CAB at pH = 3, respectively). The results show that the adsorption and wear resistance of the modified materials are improved obviously.
Copper Chaperone for Superoxide Dismutase Expression is Down-Regulated and Correlated with More Malignant Tumoral Features and Poor Prognosis in Human Hepatocellular Carcinoma
Authors: Wen Chun-yong , Shan Chang-liang , Sun Wen-jing , Wan Yuan , Lin Run , Chen Bin , Dai Hai-tao , Tang Ke-yu , Xiang Xian-hong , Yang Jian-yong , Li Nan , Yonghui Huang 
Published: October 2021

Abstract
Background: Up-regulated expression of copper chaperone for superoxide dismutase (CCS) is identified in a multitude of tumors and is closely related to more malignant tumoral biological behaviors. However, little is known about the role of CCS in hepatocellular carcinoma (HCC). This study aims to explore the expression pattern and the significance of CCS in human HCC.Methods: Fresh samples of HCC with paired adjacent tissues were obtained from 32 patients who underwent hepatectomy. The expression levels of CCS and representative malignant biomarkers in HCC were investigated by western blotting and immunohistochemistry staining, respectively. The correlation between the expression status of CCS and the activities of selected malignant biomarkers and important drive genes of HCC oncogenesis, patient’s clinicopathological features and prognosis, were analyzed. Additional bioinformatics investigation of dataset retrieved from database were performed to further explore the role of CCS in human HCC. Results: The majority of the HCC tumor (78.1%, 25/32) presented a lower expression of CCS, whereas in the minority of the tumor (22.9%, 7/32) the expression of CCS was determined as higher. Furthermore, it was found that the expression level of CCS was significantly correlated with malignant biomarkers. The expression of CCS was reversely correlated with ES grade and TNM stage to some extent. And there is a significant correlation between the CCS gene and a series of genes in the development and progression of HCC. Patients with higher CCS expression level were prone to have a better prognosis. Conclusion: HCC presented a unique lower expression pattern of CCS which reversely correlated with the more malignant tumoral features and poor prognosis.
Fractional-order Learning Algorithm for PID Neural Network Decoupling Control Based on Sparrow Search Algorithm
Authors: Wu Min , Ding Jie , Yuan Tingting , Xiao Min 
Published: October 2021

Abstract
Research on control of multi-variable system with strong coupling has been a significant issue in industry. To accurately eliminate the coupling between system variables and improve the control effect, decoupling control techniques are investigated. In this paper, a decoupling control scheme based on fractional-order proportion integration differentiation neural network and sparrow search algorithm (SSA-FPIDNN) is proposed, where sparrow search algorithm is employed to derive the optimal initial weights, preventing the weights from falling into the local optimum, while the fractional-order algorithm is used to correct its connection weights to improve control accuracy. Compared with traditional PIDNN, the proposed SSA-FPIDNN has better decoupling control performance, and the tracking time can be reduced significantly. Numerical simulation and engineering examples verified its effectiveness.
Basic Life Support a Necessary Inclusion in The Medical Curriculum. A Multi-University Cross-Sectional Study in Uganda
Authors: Ssewante Nelson , Wekha Godfrey , Iradukunda Angelique , Musoke Phillip , Kanyike Andrew Marvin , Nabukeera Germinah , Wamala Nicholas Kisaakye , Zziwa Wilson , Kamuhangire Lauben , Kajjimu Jonathan , Luggya Tonny Stone , Tagg Andrew 
Published: October 2021

Abstract
Background: Uganda continues to depend on a health system without a well-defined emergency response system. This is in the face of the rising cases of out-of-hospital cardiac arrest contributed largely to the high incidence of road traffic accidents. Non-communicable diseases are also on the rise further increasing the incidence of cardiac arrest. Medical students are key players in the bid to strengthen the health system which warrants an assessment of their knowledge and attitude towards BLS inclusion in their study curricula.Methods: A descriptive cross-sectional study was conducted in 2021 among undergraduate medical students across eight public and private universities in Uganda. An online-based questionnaire was developed using Google forms and distributed via identified WhatsApp groups. Chi-square or Fisher’s exact test and logistic regression were performed in STATA 15 to assess the association between knowledge of BLS and demographics. P<0.05 was considered statistically significant.Results: Out of the total 354 entries obtained, 351 were analyzed after eligibility screening. Of these, (n=250, 71.2%) were male less than 25 years (n=273, 77.8%). Less than half (n=150, 42.7%) participants had undergone formal BLS training.Less than a third of participants (n=103, 29.3%) had good knowledge (≥50%) with an overall score of 42.3±12.4%. Age (p=0.045), level of academic progress (p=0.001), and prior BLS training (p=0.033) were associated with good knowledge. Participants with prior training were more likely to have more BLS knowledge (aOR: 1.7, 95% CI: 1.1-2.7, p=0.009). The majority (n=348, 99.1%) believed that BLS was necessary and would wish (n=343, 97.7%) to have it included in their curriculum.Conclusion: Undergraduate medical students have poor BLS knowledge but understand its importance. Current curricula should be revised to accommodate both the theoretical and practical aspects of BLS provision to meet the priority needs of Uganda’s health system.
COVID-19 Vaccine Acceptance in Mukalla City, Yemen
Authors: Bin-Ghouth Abdulla , Al-Kaldy Khaled Hussien 
Published: October 2021

Abstract
Background: In Yemen the epidemiology of COVID19 is uncertain. Yemen received the first batch of AstraZeneca vaccine in April 2021 and the vaccine campaign starts officially on 20 April 2021 with limited utilization. Media play a negative role about AstraZeneca vaccine safety and efficacy.Objectives: to investigate the acceptance of People and health workers in Mukalla city in Hadharmout (at eastern Yemen) toward the COVID-19 vaccine.Methodology: This is a cross-sectional study to collect data from a convenience sample of health workers and other people during the first week of April 2021. Results: A total of 321 persons agree to participate in the study. Only 9% of the participants and 22% of health workers have knowledge about the COVID19 vaccine, only 15% of people and 26% of health workers agree to get the vaccine while 241 participants (75%) hesitated to get the vaccine. The most reasons for vaccine hesitancy were: the vaccine were arrived to Yemen of bad quality (69%), while 48% of hesitated participants said that the vaccine is unsafe, other reasons for unacceptance the vaccine are: regional believes (38%), other countries stop the vaccine (37%) while 16% of refused participants said that the reason is that the virus is subject to mutation so no need to vaccinate. Conclusions: Lack of knowledge about COVID-19 vaccine and high level of vaccine hesitancy were reported, the most frequent reasons for not accepted the vaccine are: bad quality of the vaccine and doubts about vaccine safety.
A Techno-Economic Investigation on Hydrogen Utilization as a Long-term Energy Storage Solution for Microgrids
Authors: Islam Sharika Manjuma , Ferdous Sambit Al , Bhuyan A.M Shamsur Rahman , Sultana Syeda Maria , Sarker Sunit , Jamal Taskin 
Published: October 2021

Abstract
The study aims to demonstrate a standalone PV-Hydrogen-battery microgrid's technical and economic merits in a developing country. Besides having fossil fuel resources, enough renewable energy resources have been deployed in the microgrid to create a sustainable system. The primary renewable energy resource explored is the solar PV system. The diesel-powered generators are integrated to support the system stability in high PV penetration scenarios. In such cases, energy storage options are integrated to store excess electricity, provide sufficient days of autonomy, system stability and virtual inertia. Li-ion based batteries and Hydrogen have received widespread acceptance as a potential renewable energy storage solution for coping with the variability nature of renewable energy resources. In this study, the system is optimized based on the seasonal load and real-life market information. The results reveal that a diesel-PV-Hydrogen-battery microgrid is an efficient and cost-effective configuration for remote communities in Bangladesh.
Microwave-assisted periodate oxidation as a rapid and efficient alternative to oxidize bacterial cellulose wet membrane
Authors: de Vasconcelos Luisa Macedo , Vasconcelos Niédja Fittipaldi , Lomonaco Diego , Rosa Morsyleide de Freitas , Rodriguez-castellon Enrique , Andrade Fábia Karine , Vieira Rodrigo Silveira 
Published: October 2021

Abstract
Bacterial cellulose (BC) membrane is a biopolymer whose excellent properties allow several applications (especially in the biomedical field, due to its high purity). Chemically, BC presents a structure susceptible to be modified to direct new functionalities according to the desired application. The microwave-assisted chemical modification (via NaIO4) of the wet BC membrane is the innovation of this work to reduce reaction times, favoring oxidation on the membrane surface, and preserving its physical and mechanics properties. The wet BC membrane was oxidized in the absence of light at 90 ºC for 30 minutes. Periodate concentration (0.75% or 1%, w/v) and heating method (microwave or water bath) in the oxidation reaction were evaluated. Fourier transform infrared and X-ray photoelectron spectroscopies confirmed the oxidation of hydroxyls to aldehyde groups in the cellulose structure. Using 1% (w/v) periodate, the degree of oxidation of microwave oxidized membranes was 51.1% higher than that of water bath oxidized membranes. Thermal analysis of oxidized bacterial cellulose (OxBC) showed a 13% reduction in degradation temperature compared to BC, remaining stable up to 250°C. Microwave OxBC showed crystallinity close to that of BC, indicating that this heating method did not affect the crystal structure of cellulose. The microwave heating method promotes less damage to the nanofibrillar structure of OxBC by providing that the oxidation reaction occurs preferentially on the surface of the wet membrane (outer layers), preserving more internal structures, in which it tends to maintain the physical and mechanical properties of the BC membrane.
Should RECOVERY have used Response Adaptive Randomization? Evidence from a simulation study
Authors: Sirkis Tamir , Bowden Jack , Jones Benjamin 
Published: October 2021

Abstract
Background The Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial is aimed at addressing the urgent need to find effective treatments for patients hospitalised with suspected or confirmed COVID-19. The trial has had many successes, including discovering that dexamethasone is effective at reducing COVID-19 mortality, the first treatment to reach this milestone in a randomised controlled trial. Despite this, it continues to use standard or `fixed’ randomization (FR) to allocate patients to treatments. We assessed the impact of implementing response adaptive randomization (RAR) within RECOVERY using an array of performance measures, to learn if it could be beneficial going forward. This design feature has recently been implemented within the REMAP-CAP trial.Methods Trial data was simulated to closely match the data for patients allocated to either standard care or dexamethasone in the RECOVERY trial from March-June 2020, representing two out of five arms tested throughout this period. Two forms of FR and two forms of RAR were tested. Randomization strategies were performed at the whole trial level as well as within three pre-specified patient subgroups defined by patients’ respiratory support level.ResultsRAR strategies led to more patients being given dexamethasone and a lower mortality rate in the trial. Subgroup specific RAR reduced mortality rates even further. RAR did not induce any meaningful bias in treatment effect estimates, but reduced statistical power compared to FR, with subgroup level adaptive randomizations exhibiting the largest power reduction.ConclusionsUsing RAR within RECOVERY could have resulted in fewer deaths in the trial. However, a larger trial would have been needed to attain the same study power. This could potentially have prolonged the time to full approval of the drug, unless RAR itself led to an increased recruitment rate. Deciding how to balance the needs of patients within a trial and future patients who have yet to fall ill is an important ethical question of our time. RAR deserves to be considered as a design feature in future trials of COVID-19 and other diseases.
Gut Microbiota Composition and Functional Prediction in Recurrent Spontaneous Abortion
Authors: Cui Ying , Zou Li , Ye Qian , Li Dandan , Wu Huiming , He Ling 
Published: October 2021

Abstract
Objective The changes of microbial community in pregnant women, let alone those of patients with recurrent spontaneous abortion (RSA), remain unclear. We analyzed the differences of gut mircobiota (GM) between RSA patients and pregnant women to find the possible mechanism of RSA. MethodsWe enrolled 30 RSA patients (RSA group) and 30 pregnant women who terminated their pregnancy and did not have a history of spontaneous abortion (NR group) in our hospital from June 2020 to August 2020, and fecal samples were obtained to analyze the GM using 16S rDNA V3–V4 sequencing.ResultsAt the phylum level, we found that there is no significant difference in composition of GM between RSA and NR. But at the genus level, compared with NR, Roseburia significantly decreased (P<0.01), and Ruminococcus significantly increased in RSA patients (P<0.05). Further analysis indicated that Klebsiella (P<0.05) was significantly increased, Prevotella.9 (P<0.05) and Roseburia (P<0.05) were significantly decreased in RSA2 group (BMI>23.9 in RSA). Moreover, Agathobacter (P<0.01) was significantly increased in NR2 group (no delivery in NR). Functional prediction indicated that GM may interfere with RSA through membrane transport, carbohydrate metabolism, amino acid metabolism and other pathways.ConclusionDecreased Roseburia in GM of pregnant women maybe related to RSA. Our results provide the basis for in-depth studies of the composition of gut microbial communities in RSA.
Illuminating Health Aspects for Immigrant Thai Women Living in Swedish Transnational Marriages
Authors: Pongthippat Weerati , Östlund Gunnel , Darvishpour Mehrdad , Kijsomporn Jureerat , Gustafsson Lena-Karin 
Published: October 2021

Abstract

Background: Based on their migrant status, women experience discrimination, facing major risks including sexual exploitation, trafficking, and violence which all affect health.This study explores critical health incidents of marriage migration and their consequences experienced by immigrant Thai women in everyday life.Methods: A qualitative explorative approach with in-depth interviews. 40 immigrant Thai women having or having had a Swedish spouse. Critical incident technique was used to collect and analyse data in combination with content analysis.Results: The women reported 438 critical health incidents in five main areas: Psychological health dilemmas with consequences such as detrimental insecurity, loss of human value and devastating grief. Sociocultural health dilemmas leading to exploitation, insecurity, feelings of betrayal and rage. Physiological health dilemmas leading to economic strain, emotional strain, and physical pain. Developmental health dilemmas are affected by the process of ageing and facing threatening incidents related to deteriorating health. Spiritual health dilemmas including critical incidents in which the women intensified their dependence on faith and karma. Discussion: Women in marriage migration face major health dilemmas while adapting to their new country. Healthcare providers should be concerned about migrated women’s complex situations, as these affect both health and welfare.
A Sensitive, Robust Method for Determining nNatural and Synthetic Hormones in Surface and Waste Waters by Continuous Solid Phase Extraction–Gas Chromatography–Mass Spectrometry
Authors: Chafi Safae , Ballesteros Evaristo 
Published: October 2021

Abstract
One recent trend in Analytical Chemistry is to develop economical, fast green methods using minimal amounts of solvents to determine a variety of analytes spanning a wide range of physicochemical properties. In this work, we developed a sensitive, selective method for the simultaneous determination of thirteen natural and synthetic hormones present at the nanogram-per-liter level in various types of water by using continuous solid phase extraction in combination with gas chromatography and mass spectrometry (GC–MS). The target analytes were preferentially sorbed on an Oasis HLB sorbent column and eluted with acetone for derivatization with a mixture of N,O-bis(trimethylsilyl) trifluoroacetamide and trimethylchlorosilane in a household microwave oven at 200 W for 4 min. Under optimum conditions, the ensuing method exhibited good linearity (r ≥ 0.998), good precision (RSD ≤ 7%), high recoveries (92–103%) and low detection limits (0.01–0.3 ng L− 1). The method outperforms existing alternatives in robustness, sensitivity, throughput, flexibility —it allows both estrogens, progestogens and androgens to be determined simultaneously— and compliance with the principles of Green Chemistry. It was successfully used to analyze various types of water samples (mineral, tap, well, pond, swimming pool, river and waste) that were found to contain four estrogens (estrone, 17β-estradiol, 17α-ethinylestradiol and hexestrol), two progestogens (testosterone, dihydrotestosterone) and one progestogen (progesterone) at concentrations ranging from 3.0 to 110 ng L− 1.
Uncovering The Mechanism of Shiwuwei Luodimingmu Wan On Cataract Via Network Pharmacology
Authors: Zhang Zhanhao , Wang Yuliang , Lu Hongyan , He Yongjun , Wang Li , Zheng Jianwen , Jin Tianbo 
Published: October 2021

Abstract
Cataract is one of the most common eye diseases. The purpose of this study was to screen the active components and potential targets of Shiwuwei Luodimingmu Wan, then to explore the mechanism of Shiwuwei Luodimingmu Wan in the treatment of cataract through network pharmacology. Information about the chemical constituents and their targets of herbs in Shiwuwei Luodimingmu Wan was collected from traditional Chinese medicine system pharmacology (TCMSP) database. Cataract related genes were searched in Pubmed-Gene database and Genecards database. Then, the possible protein-protein interactions (PPIs) were derived from STRING database. Next, compound-target-diseases network was constructed using Cytoscape software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using DAVID. Furthermore, we evaluated binding potential of key targets and compounds through molecular docking. There were 102 active components including quercetin, baicalein and kaempferol in Shiwuwei Luodimingmu Wan and 28 potential targets related to cataract. More importantly, these genes are involved in several pathways associated with cataract. Docking results showed that core compound (quercetin) had certain affinity with MAPK14. This study revealed that the ability of Shiwuwei Luodimingmu Wan to produce clarity of vision may was achieved through quercetin to affect multiple targets and pathways.
Obesity, Pregnancy and Lifestyle Clinic: Evaluation and Outcomes
Authors: Schulte Rhea , Monaghan Abby , Rane Vinita 
Published: October 2021

Abstract
Background: Increasing numbers of women are entering pregnancy with an elevated body mass index (BMI). Elevated maternal BMI is associated with a number of adverse obstetric and neonatal outcomes, however attention to diet and lifestyle during the antenatal period has been shown to reduce the rate of many of these complications. The Obesity, Pregnancy and Lifestyle (OPAL) clinic was started at the Northern Hospital in July 2018 to provide specialised antenatal care to women with Class III obesity (BMI ≥ 40 kg/m2). Methods: We performed a retrospective cohort study of women with a BMI ≥ 40kg/m2 delivering a singleton pregnancy at the Northern Hospital, Melbourne, Victoria, between January 2019 and April 2020, comparing obstetric and neonatal outcomes of women who attended the OPAL clinic (n=60) to those who received standard antenatal care (n=121). Statistical analysis performed using χ2, Fisher’s Exact Test, Student’s T-test and Mann-Whitney (rank sum) test with a significance level of 0.05.Results: Compared to similar women in standard antenatal care, women who attended the OPAL clinic are more likely to be younger (mean age 29 vs 32, p = 0.001), to be primiparous (OR 2.65 (1.33-5.28), p = 0.005) and to be born in Australia or New Zealand (OR 0.47 (0.22-1.03), p = 0.057).OPAL women also attended a significantly higher number of antenatal appointments (9 vs 8, p=0.017) and had a lower median gestational age of delivery (38.3 vs 38.5, p=0.024).Conclusions: These results suggest that the OPAL clinic has achieved increased engagement of women with class III obesity in antenatal care. However, significant demographic differences indicate there is a subset of women still not receiving specialist care despite best intentions, indicating clinic processes are in need of review. Future research should focus on the patient experience of women attending the OPAL clinic.