bluuebunny/crossref_metadata_2025_split huggingface dataset:
СУТНІСТЬ ТА СПЕЦІФІКА ІНФРАСТРУКТУРНИХ ПРОЄКТІВ НА ВОДНОМУ ТРАНСПОРТІ
Authors: Nemchuk O.O. , Vereshchaka N.A. , Onyshchenko S.P. 
Published: April 2021

Вступ. Успішність інфраструктурних заходів визначається успішністю реа- лізації відповідних проєктів: навіть дуже своєчасні і необхідні заходи можуть не бути доведені до логічного кінця або не забезпечити отримання необхідного результату, якщо управління відповідними інфраструктурними проєктами здій- снюється неналежним чином. Тому для забезпечення успішності та ефективнос- ті цієї категорії проєктів необхідна відповідна теоретична база для підтримки процесів управління. Фундаментом цієї теоретичної бази має бути чітка іден- тифікована сутність та специфіка інфраструктурних проєктів у сфері водного транспорту, бо саме це визначає специфіку процесів управління цими проєктами. Метою дослідження є ідентифікація основних видів інфраструктурних проєк- тів у сфері водного транспорту і встановлення їх специфіки як основи для роз- робки моделей і методів ефективного управління цими проєктами. Результати. У цьому дослідженні ідентифіковано сутність і специфіка інфраструктурних проєктів на водному транспорті. Визначено логічний ланцюжок впливу стану і параметрів цієї інфраструктури на різні параметри транспортного обслугову- вання і конкурентоспроможність транспортної системи країни. Отже, стан інфраструктури визначає безпеку судноплавства, формує обмеження на розмір суден (і, відповідно, розмір вантажних партій), а також зумовлює час рейсу суд- на і доставки вантажу. Таким чином, розвиток інфраструктури водного тран- спорту є необхідним чинником підвищення конкурентоспроможності портів та ефективності морських і річкових перевезень. Крім того, розвиток технологій і діяльність міжнародних організацій (наприклад, ІМО) зумовлюють більш високі вимоги до забезпечення безпеки судноплавства, що також відбивається на вимо- гах до інфраструктури. Крім того, інфраструктура водного транспорту підда- на не тільки «моральному» старінню, а й природному «зносу», причому більшою мірою, ніж в інших видів транспорту. Це пояснюється «агресивністю» водного середовища і природними процесами (наприклад, замулюванням дна). Встановле- но основні види інфраструктурних проєктів на водному транспорті: модерніза- ція об’єктів; заміна об’єктів; відновлення об’єктів; розвиток існуючих об’єктів; створення нових об’єктів. Визначено продукти інфраструктурних проєктів – це об’єкти інфраструктури, які або створюються, або змінюються (відновлення, заміна, модернізація, розвиток). Встановлено цілі і місію цієї категорії проєк- тів. Висновки. Отримані результати є основою для розробки моделей і методів управління інфраструктурними проєктами на водному транспорті.
A 26-year-old female with faulty existing restorations
Authors: Yadav Ram Udgar , Ahmed Sageer , Hossain Mozammal 
Published: April 2021

This article has no abstract. The first 100 words appear below:
A 26-year-old female came with unaesthetic restorations on the upper four anterior teeth. She gave a history of the restoration of the teeth 6 months ago that underwent progressive marginal discoloration. On clinical examination, two upper central and two lateral incisor teeth were restored by Glass Ionomer cement and Secondary caries were present beneath restorations. Teeth were vital and did not respond to percussion and mobility test. Radiographic examination revealed that the four maxillary anterior teeth (2 central and 2 laterals) had the existing restoration which showed a radioopaque area in the proximal surface but radiolucent areas were also seen beneath the radioopaque area that extends to the dentin.
Governança Corporativa e Governança de Tecnologia da Informação como vantagem competitiva nas organizações
Authors: Peixe Adriana Maria Miguel , Balsan Jorge , Pinto José Simão de Paula 
Published: April 2021

A Tecnologia da Informação fundamentada em seus resultados e necessidades de utilização, possui no contexto atual, um cenário oportuno e relevante. Ela torna-se fundamental nas estratégias das empresas, explorando oportunidades e gerando vantagens competitivas em todos os níveis de gestão. Seus impactos são notórios nos níveis internos e externos das organizações: na estrutura orgânica e no papel de enquadramento/coordenação na organização; a nível psico-sociológico e das relações pessoais; no subsistema de objetivos e valores das pessoas que trabalham nas organizações; bem como no subsistema tecnológico. Neste contexto, o estudo teve como objetivo enfatizar o framework (estrutura) praticado e sua importância no contexto das vantagens competitivas nas organizações. Para atender à crescente demanda por inovação, criatividade, qualidade, melhoria de processos, competitividade dentre tantas outras necessidades neste mundo globalizado. Como delineamento metodológico, o artigo caracteriza-se como uma pesquisa bibliográfica, exploratória, documental, descritiva, explicativa e qualitativa. Infere-se que a janela de vantagem (período de tempo que leva para os concorrentes alcançar e igualar a vantagem estratégica) tornou-se questão crítica em termos de gerenciamento. O desafio é encontrar as conexões gerenciais entre a TI, as soluções propostas e necessárias de tecnologia de informação, que atendam às necessidades de negócios, e os objetivos do negócio.
Model Of Punishment: Juvenile Justice Systems
Authors: Nur Rafika , Bakhtiar Handar Subhandi , Miqat Nurul , Darmawati Darmawati , Mustawa Mustawa 
Published: April 2021

The position of children who have special rights in the law makes children get special treatment. In the juvenile justice system in Indonesia, there are two systems of sanctions, namely criminal sanctions and actions, and this is done to realize the protection of children who are dealing with the law. This research is a normative juridical review, using a statute, comparative and conceptual approaches. The results show that the imposition of sanctions on children is based on the child's age, where children aged 12 to before 14 years can only be sanctioned with actions, and children aged 14 to before 18 years may be subject to criminal sanctions or actions.
Pengaturan cahaya pada pertumbuhan bunga krisan potong di dalam prototype greenhouse
Authors: Fauziyah Mila , Safitri Hari Kurnia , Murtono Ari , Dewatama Denda , Aulianta Erdin 
Published: April 2021

Cahaya merupakan faktor lingkungan yang diperlukan untuk mengatur proses fotosistensis khususnya pada bunga krisan potong. Pada fase vegetatif dari bunga krisan potong diperlukan penambahan cahaya di malam hari agar diperoleh bunga krisan potong dengan kualitas yang diharapkan yaitu dengan ketinggian lebih dari 80 cm. Berdasarkan hal tersebut maka dirancang suatu sistem pengaturan intensitas cahaya bunga krisan potong dengan menggunakan metode ON-OFF dan Metode PWM. Untuk metode ON-OFF ini digunakan dengan cara pembacaan cahaya dengan sensor LDR diluar prototype greenhouse untuk mematikan lampu pada siang hari. Sedangkan metode PWM digunakan untuk mengatur gelap dan terang dari lampu pada saat malam hari menggunakan sensor infrared. Didapatkan hasil bunga krisan potong pada fase vegetatif menunjukkan bahwa sistem mampu mempercepat pertumbuhan bunga krisan potong 7 hari lebih cepat dari standard waktu tumbuh 30 hari dan ketinggian bunga bertambah sekitar 7-8 cm perminggunya.

Light is an environmental factor needed to regulate the photosistensis process, especially in cut chrysanthemums flower. In the vegetative phase of the cut chrysanthemum, it is necessary to add light at night to obtain cut chrysanthemum flowers with the expected quality, namely with a height of more than 80 cm. Based on this, a system of light intensity control of cut chrysanthemum flowers was designed using the ON-OFF method and the PWM method. The ON-OFF method is used by reading the light with the LDR sensor outside the prototype greenhouse to turn off the lights during the day. While the PWM method is used to adjust the dark and lightness of the lights at night using an infrared sensor. The results of the cut chrysanthemum flower in the vegetative phase showed that the system was able to accelerate the growth of cut chrysanthemum flowers 7 days faster than the standard 30-day growing time and the flower height increased by around 7-8 cm per week.
Live Imaging of Calciprotein Particle Clearance and Receptor Mediated Uptake: Role of Calciprotein Monomers
Authors: Koeppert Sina , Ghallab Ahmed , Peglow Sarah , Winkler Camilla Franziska , Graeber Steffen , Büscher Andrea , Hengstler Jan Georg , Jahnen-Dechent Willi 
Published: April 2021

BackgroundThe liver-derived plasma protein fetuin A is a systemic inhibitor of ectopic calcification. Fetuin-A stabilizes calcium phosphate mineral initially as ion clusters to form calciprotein monomers (CPM), and then as larger multimeric consolidations containing amorphous calcium phosphate (primary CPP, CPP 1) or more crystalline phases (secondary CPP, CPP 2). CPM and CPP mediate excess mineral stabilization, transport and clearance from circulation.MethodsWe injected i.v. synthetic fluorescent CPM and studied their clearance by live two-photon microscopy. We analyzed organ sections by fluorescence microscopy to assess CPM distribution. We studied cellular clearance and cytotoxicity by flow cytometry and live/dead staining, respectively, in cultured macrophages, liver sinusoidal endothelial cells (LSEC), and human proximal tubule epithelial HK-2 cells. Inflammasome activation was scored in macrophages. Fetuin A monomer and CPM charge were analyzed by ion exchange chromatography.ResultsLive mice cleared CPP in the liver as published previously. In contrast, CPM were filtered by kidney glomeruli into the Bowman space and the proximal tubules, suggesting tubular excretion of CPM-bound calcium phosphate and reabsorption of fetuin A. Fetuin-A monomer clearance was negligible in liver and low in kidney. Anion exchange chromatography revealed that fetuin A monomer was negatively charged, whereas CPM appeared neutral, suggesting electrochemical selectivity of CPM versus fetuin A. CPM were non-toxic in any of the investigated cell types, whereas CPP 1 were cytotoxic. Unlike CPP, CPM also did not activate the inflammasome.ConclusionsFetuin-A prevents calcium phosphate precipitation by forming CPM, which transform into CPP. Unlike CPP, CPM do not trigger inflammation. CPM are readily cleared in the kidneys, suggesting CPM as a physiological transporter of excess calcium and phosphate. Upon prolonged circulation, e.g., in chronic kidney disease, CPM will coalesce and form CPP, which cannot be cleared by the kidney, but will be endocytosed by liver sinusoidal endothelial cells and macrophages. Large amounts of CPP trigger inflammation. Chronic CPM and CPP clearance deficiency thus cause calcification by CPP deposition in blood vessels and soft tissues, as well as inflammation.
Serum Complement C1q Activity Is Associated With Obstructive Coronary Artery Disease
Authors: Guo Shuren , Mao Xiaohuan , Li Xiaohua , Ouyang Huan , Gao Yuhua , Ming Liang 
Published: April 2021

Background:Complement C1q plays a dual role in the atherosclerosis. Previous studies showed inconsistent results about the association of serum C1q levels and coronary artery disease (CAD). Here, we explored the associations of serum C1q activity with CAD, coronary stenosis severity, cardiovascular biomarkers, and 1-year restenosis after coronary artery revascularization.Methods:We enrolled 956 CAD patients and 677 controls to evaluate the associations of serum complement C1q activity to the presence and severity of obstructive CAD and non-obstructive CAD. Serum C1q activity and the concentrations of laboratory markers were measured in all subjects. All the data were analyzed using SPSS22.0 software.Results:Serum C1q activity in Obstructive CAD and Non-Obstructive CAD groups was significantly higher than the control group (195.52 ± 48.31 kU/L and 195.42 ± 51.25 kU/L vs. 183.44 ± 31.75 kU/L,P&lt; 0.05). Greater C1q activity was significantly correlated with higher total cholesterol (TC) and triglyceride (TG) levels. C1q activity was associated with an increased Odds Ratio (OR) of CAD (OR = 1.322, 95% CI 1.168–1.496,P&lt; 0.05) and 1-year restenosis after revascularization (the highest OR = 3.544, 95% CI 1.089–12.702,P&lt; 0.05). Complement C1q activity was not correlated with Gensini score in the Obstructive CAD group after adjustment for confounders. C1q activity has low value in predicting the incidence of CAD.Conclusion:Serum complement C1q activity is associated with obstructive CAD.
Safety and Efficacy of Vitamin K Antagonists vs. Novel Oral Anticoagulants in Patients With Left Ventricular Thrombus: A Meta-Analysis
Authors: Xuan He , Chen Yi-Ming , Dai Yun-Lang , Zhou Jing , Jiang Yu-Feng , Zhou Ya-Feng 
Published: April 2021

Aims: A meta-analysis was conducted to evaluate the safety and efficacy of novel oral anticoagulants (NOACs) compared with vitamin K antagonists (VKAs) in patients with left ventricular thrombus (LVT).Methods and Results: We searched PubMed, Web of Science, and Cochrane Library for cohort studies comparing the use of VKAs vs. NOACs for the treatment of LVT from the earliest date available to September 30, 2020. The predetermined efficacy and safety outcomes included thromboembolic events, resolution of LVT, clinically significant bleedings, and all-cause death. Fixed-effects model was used to estimate the pooled effects. Publication bias analyses and sensitivity analyses were conducted to check the robustness of results. A total of 6 studies enrolling 837 patients (mean age 60.2 ± 1.6 years; 77.2% were male) were included. We found no significant differences in thromboembolic events [relative risk (RR) 1.69, 95% confidence interval (CI) 0.94–3.06, P 0.08, I2 12.7%], the rate of resolution of thrombus (RR 1.08, 95% CI 0.96–1.21, P 0.21, I2 4.8%), and clinically significant bleedings (RR 0.70, 95% CI 0.37–1.32, P 0.27, I2 0%) between the VKAs and NOACs group. Additionally, no significant difference in all-cause mortality was found between the two groups (RR 1.24, 95% CI 0.79–1.96, P 0.35, I2 0.0%). Sensitivity analyses, using the “1-study removed” method, detected no significant differences.Conclusion: NOACs and VKAs have similar efficacy and safety in treating LVT, prompting the inference that NOACs are the possible alternatives of VKAs in LVT therapy.
Impact of Leaflet Tethering on Residual Regurgitation in Patients With Degenerative Mitral Disease After Interventional Edge-to-Edge Repair
Authors: Ge Zhenyi , Pan Wenzhi , Li Wei , Wei Lai , Kong Dehong , Pan Cuizhen , Zhou Daxin , Shu Xianhong , Ge Junbo 
Published: April 2021

Background: Grade 2+ residual mitral regurgitation (MR 2+) is associated with the recurrence of MR and a lower survival rate in interventional mitral valve (MV) edge-to-edge (EE) repair. We sought to determine the MV anatomic factors affecting residual MR 2+ during interventional EE repair with the ValveClamp system in patients with degenerative MR (DMR).Methods: In this multicenter study, 62 patients with significant (grade 3+ to 4+) DMR underwent ValveClamp implantation across eight centers from July 2018 to December 2019. Patient clinical, anatomical, and procedural characteristics were prospectively collected and retrospectively analyzed.Results: A single clamp was implanted in 59 patients, and two clamps were implanted in three patients. Residual MR 2+ was found in 14 patients (22.6%) immediately after the ValveClamp procedure. Patients with residual MR 2+ showed significantly larger preoperative tenting sizes and annular dimensions than the residual MR ≤1+ group. Multivariate analysis identified tenting volume as the major determinant of residual MR 2+ after ValveClamp procedures (odds ratio, 1.410 per 0.1-mL/m2 increase; 95% confidence interval, 1.167–1.705; P &lt; 0.001). Receiver operating characteristic curves identified a tenting volume index ≥0.82 mL/m2 as the optimal cutoff point to predict residual MR 2+ (area under curve, 0.84). Patients with a tenting volume index ≥0.82 mL/m2 were more likely to develop recurrent 3+ MR or undergo MV surgery during short-term follow-up (P &lt; 0.001).Conclusions: Preoperative assessment of the tenting volume index will help to predict intraoperative residual MR 2+ in patients with DMR receiving EE-based interventional repair. Improvements in the interventional strategy are warranted for sustained MR reduction in patients with DMR with unfavorable anatomy.
Prognostic Significance of B-Type Natriuretic Peptide in Patients With Left Ventricular Thrombus
Authors: An Zhixia , Gao Zhichun , Wang Luyu , Hou Changchun , Zhang Liying , Gong Siming , Rao Rongsheng , Li Chun , Qin Zhexue 
Published: April 2021

Background and Aims: There is sparse information on the prognostic value of B-type natriuretic peptide (BNP) for the outcomes in patients with left ventricular thrombus (LVT).Methods: Patients diagnosed with LVT by transthoracic echocardiography between November 2009 to July 2020 at our institution were included. The endpoints were all-cause mortality and systemic embolism.Results: Ninety-two subjects were finally included in the study. The mean age of the cohort was 56.73 ± 14.12, and 80.4% of the patients were male. The median BNP (1st quartile−3rd quartile) was 437.5 (112.74–1317.5). The total all-cause mortality rate was 30.44% (28/92), and the 1-year, 2-year, and 3-year cumulative survival rates were 85.4, 75.5, and 66.5%, respectively. Systemic embolism was identified in 10 subjects. COX multivariate analysis showed that Log BNP (HR, 4.16; 95%CI, 1.81–9.56; P = 0.001) and BMI (HR, 0.86; 95%CI, 0.73–0.99; P = 0.048) were significantly associated with all-cause mortality. In addition, patients with BNP levels in the upper median (≥ 437.5 pg/ml) had significantly higher all-cause mortality rate compared to those with lower median BNP (&lt;437.5 pg/ml; P = 0.004). The area under the receiver operating characteristic curve for BNP and all-cause mortality was 0.71. In the linear trend test, BNP quartiles were significantly related to all-cause mortality in all models, and the P-values for trend in models 1, 2, and 3 were 0.005, 0.006, and 0.048, respectively.Conclusion: BNP level is a prognostic factor for all-cause mortality in LVT patients, and elevated BNP is indicative of a higher risk of LVT.
Maternal and Neonatal Complications in Patients With Diminished Ovarian Reserve in In-Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles
Authors: Han Shuang , Zhai Yiwei , Guo Qingqing , Qin Yiming , Liu Peihao 
Published: April 2021

BackgroundDiminished ovarian reserve (DOR) is one of the most intractable clinical issues in human reproduction and is reported to be associated with raised risk of recurrent pregnancy loss and aneuploid blastocysts. In this study, we aimed to explore whether DOR was also associated with maternal and neonatal complications in in-vitro fertilization/intracytoplasmic sperm injection cycles.MethodsA retrospective cohort study including women below 40 years of age who achieved singleton live birth after fresh embryo transfer in in-vitro fertilization/intracytoplasmic sperm injection cycles in a single center from January 2012 to June 2019 was conducted. Participants with DOR, defined as basal follicle-stimulating hormone (FSH) ≥ 10IU/L and antimullerian hormone (AMH) &lt; 1.2ng/ml, were enrolled as the study group. The controls were 1:2 matched by age and body mass index with FSH &lt; 10IU/L and AMH ≥ 1.2ng/ml. Maternal and neonatal complications were compared between the DOR group and the controls.ResultsA total of 579 women, 193 in the DOR group and 386 matched as controls, were included in this study. Compared to controls, the incidence of hypertensive disorders of pregnancy was significantly increased in the DOR group (5.7% vs. 2.1%, P = 0.021). DOR patients also presented slightly higher incidences of preterm birth (10.9% vs. 7.5%, P = 0.174) and low birthweight (6.2% vs. 5.4%, P = 0.704) yet without statistical significances. The incidences of gestational diabetes mellitus and placenta previa were comparable between the two groups.ConclusionCompared to women with normal ovarian reserve, women with diminished ovarian reserve might have elevated incidence of hypertensive disorders of pregnancy. Patients with diminished ovarian reserve might need more strict antenatal care.
Development and Assessment of the Monthly Grid Precipitation Datasets in China
Authors: Peng Jiadong , Duan Lijie , Xu Wenhui , Li Qingxiang 
Published: April 2021

Based on the high-quality homogenized precipitation data from all 2,419 national weather stations in China, the climatology and anomaly percentage fields are derived, and then the digital elevation model (DEM) is employed to reduce the influence of elevation on the spatial interpolation accuracy of precipitation due to the unique topography in China. Then, the gradient plus inverse distance squared (GIDS) method and the inverse distance squared (IDS) method are used to grid the climatology field and the anomaly percentage field, respectively, and the 0.5 × 0.5° gridded datasets during 1961–2018 in China are obtained by combining them together. The evaluation shows that the mean absolute error (MAE) between the analysis value and the observation is 15.8 mm/month. The MAE in South China is generally higher than that in North China, and the MAE is obviously larger in summer than in other seasons. Specifically, 94.6, 54.4, 4.6, and 53.8% of the MAE are below 10 mm/month in winter (DJF), spring (MAM), summer (JJA), and autumn (SON), respectively, and 99.5, 79.9, 22.8, and 82.1% of them are less than 20 mm/month. The MAE over China in four seasons is 3.8, 13.2, 33.5, and 12.7 mm/month, respectively. This dataset has the potential of broad application prospects in the evaluations of weather and climate models and satellite products.
RETRACTED: NEAT1 Overexpression Indicates a Poor Prognosis and Induces Chemotherapy Resistance via the miR-491-5p/SOX3 Signaling Pathway in Ovarian Cancer
Authors: Jia Xinzhuan , Wei Lan , Zhang Zhengmao 
Published: April 2021

BackgroundAccumulated studies have reported that dysregulated long non-coding RNAs (lncRNAs) are crucial in ovarian cancer (OC) initiation and development. However, detailed biological functions of lncRNA NEAT1 during the progression of OC remains to be uncovered.PurposeOur aim was to identify the role of NEAT1 in cisplatin resistance of ovarian cancer and the underlying mechanisms.MethodsThe expression patterns of NEAT1 in OC cell lines and tissue samples were identified by qRT-PCR. The cisplatin (DDP) sensitivity of OC cells was detected by MTT and CCK8 assay, while OC cell apoptosis and cell cycle were detected using flow cytometer assays. In addition, effects of NEAT1 on tumor growth were determined by xenograft tumor model. Luciferase reporter assay was conducted to prove the regulatory relation of miR-491-5p, NEAT1, and SOX3. Importantly, the expression of NEAT1 in exosomes from cisplatin-resistant patients was also determined by using qRT-PCR.ResultsIn this study, upregulated NEAT1 was detected in OC cell lines and tissues. Meanwhile, NEAT1 was also increased in cisplatin-resistant OC cell lines and tissues. Upregulation of NEAT1 inhibited cisplatin-induced OC cell apoptosis and promoted cell proliferation, while knockdown of NEAT1 played the opposite role. These effects were also observed in vivo. Furthermore, direct interaction was observed between NEAT1 and miR-491-5p. NEAT1 led to the upregulation of miR-491-5p-targeted SOX3 mRNA. Importantly, this study also showed upregulated NEAT1 expression in serum exosomes derived from cisplatin-resistant patients.ConclusionNEAT1 is vital in the chemoresistance of ovarian cancer through regulating miR-491-5p/SOX3 pathway, showing that NEAT1 might be a potential target for OC resistance treatment.