bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antecedents of business location decisions: the case of aspiring immigrant opportunity entrepreneurs
Authors: Simarasl Nastaran , Moghaddam Kaveh , Williams David W. 
Published: August 2021

PurposeThe purpose of this paper is to investigate aspiring immigrant opportunity (AIO) entrepreneurs' start-up location decisions.Design/methodology/approachThe authors used conjoint analysis to explore 1,264 location decisions nested within 79 highly educated, first-generation AIO entrepreneurs.FindingsThe authors found that although government support positively influences business location decisions, network support decreases the perceived benefits of government support for AIO entrepreneurs. Furthermore, locations with high costs of doing business are unattractive to AIO entrepreneurs, but financial capital access through ethnic and nonethnic sources in these locations enhances the appeal of high-cost locations.Research limitations/implicationsThe generalizability of the findings to AIO entrepreneurs should be considered with caution. Future research should longitudinally examine immigrant opportunity entrepreneurs' location decisions and their implications for their start-up and community-level performance outcomes. The authors also encourage replication of the study.Practical implicationsThe findings of this study have implications for AIO entrepreneurs who intend to make start-up location decisions. Also, government policymakers can use the findings of this study to better attract AIO entrepreneurs to different locations.Originality/valueBy integrating ethnic enclave theory and location theory, this research contributes to theory and practice about immigrant opportunity entrepreneurs' start-up location decisions which are currently underexplored in the immigrant entrepreneurship literature.
The Twilight Effect, post-film tourism and diversification: the future of Forks, WA
Authors: Wright Daniel William Mackenzie , Jarratt David , Halford Emma 
Published: August 2021

PurposeThe visitor economy of Forks now clearly relies upon a niche form of tourism – as fans of The Twilight Saga are drawn to the setting and filming location of the films. The purpose of this study is to consider the process of diversification and subsequently present recommendations that could inform a future diversification strategy for Forks, in preparation for a post-film tourism scenario.Design/methodology/approachThe research methods employed in this study have two interlinked but distinct elements. Firstly, the Twilight Effect in Forks (WA, USA) is considered as an illustrative case study to shed light on the issues facing a destination that has seen a tourism boom as a direct result of popular culture – The Twilight Saga Franchise. Secondly, a scenario thinking and planning approach is applied when considering the “long-view” future of tourism in Forks.FindingsThis article presents a post-film tourism future scenario for Forks; it suggests tourism diversification and a shift towards cultural heritage and wellness. Forks is well placed to afford such tourism experiences, as it offers unique cultural and natural characteristics; furthermore, these could be utilised to create and maintain a distinctive destination image. In doing so a more socially and environmentally sustainable industry can be established, one which supports the local community, including the Quileute tribe.Originality/valueThe article offers original discussions within the film-tourism literature with novel approaches to understanding the management and pre-planning opportunities for destinations that have become popular film tourism locations, with the application of a “Tourism Diversification Model”. The model is adapted from Ansoff Matrix and can be applied as a framework in future studies exploring destination diversification. The investigation of Forks as a post-film tourism case study alone is unique, and the discussions and findings presented are original.
Toward customer-centric mobile phone reverse logistics: using the DEMATEL approach and social media data
Authors: Shokouhyar Sajjad , Dehkhodaei Amirhosein , Amiri Bahar 
Published: August 2021

PurposeRecently, reverse logistics (RL) has become more prominent due to growing environmental concerns, social responsibility, competitive advantages and high efficiency by customers because of expansion of product selection and shorter product life cycle. However, effective implementation of RL results in some direct advantages, the most important of which is winning customer satisfaction that is vital to a firm's success. Therefore, paying attention to customer feedback in supply chain (SC) and logistics processes has recently increased, so manufacturers have decided to transform their RL into customer-centric RL. Hence, this paper aims to identify the features of a mobile phone which affect consumers’ purchasing behavior and to analyze the causality and prominence relations among them that can help decision-makers, policy planners and managers of organizations to develop a framework for customer-centric RL. These features are studied based on analysis of product review sites. This paper's special focus is on social media (SM) data (Twitter) in an attempt to help the decision-making process in RL through a big data analysis approach.Design/methodology/approachThis paper deals with identifying mobile phone features that affect consumer's mobile phone purchasing decisions. Using the DEMATEL approach and using experts' insights, a cause and effect relationship diagram was generated through which the effect of features was analyzed.FindingsEighteen features were categorized in terms of cause and effect, and the interrelationships of features were also analyzed. The threshold value is calculated as 0.023, and the values lower than that were eliminated to obtain the digraph. F6 (camera), F13 (price) and F5 (chip) are the most prominent features based on their prominent score. It was also found that the F5 (chip) has the highest driving power (1.228) and acts as a causal feature to influence other features.Originality/valueThe focus of this article is on SM data (Twitter), so that experts can understand the interaction between mobile phone features that affect consumer's decision on mobile phone purchasing by using the results. This study investigates the degree of influence of features on each other and categorizes the features into cause and effect groups. This study is also intended to help organizational decision-makers move toward a reverse customer SC.
Effect of aging and finish machining on the surface integrity of selective laser melted maraging steel
Authors: Tascioglu Emre , Khan Hamaid Mahmood , Kaynak Yusuf , Coşkun Mert , Tarakci Gurkan , Koç Ebubekir 
Published: August 2021

Purpose
The present study aims to investigate the effect of finish machining and aging processes on the surface integrity of the selective laser melted (SLM) maraging steel samples and compared them with those obtained conventionally.

Design/methodology/approach
Finish machining and aging were applied on the SLM and wrought maraging samples to investigate and compare their microstructural and mechanical properties such as surface roughness, microhardness and wear resistance.

Findings
After applying aging and finish machining treatments, the surface roughness <1 µm, microhardness (542Hv) and wear resistance (COF 0.578) of SLM samples were similar to their wrought counterparts. Compared to finish machining, the effect of aging was more significant on the microhardness and the wear resistance, regardless of sample type.

Originality/value
The knowledge of post-processing is essential to enhance the functional performance of the SLM samples. Aging and finish machining were applied for the first time to evaluate the surface integrity of the SLM prepared maraging steel and compared it with the wrought samples.
Conserved immunogenic peptides of Ebola glycoprotein elicit immune response in human peripheral blood mononuclear cells
Authors: Jain Sahil , Baranwal Manoj 
Published: August 2021

AbstractIn the past 45 years, ebolaviruses have periodically caused epidemics on the African continent. In December 2019, approval of a recombinant vector‐based EBOV vaccine, named Ervebo, came as encouraging news; still, there is a long way to go in the development of an accessible, global, and pan‐ebolavirus vaccine. The current study expanded our previous in silico work which was conducted on ebolavirus glycoprotein and this resulted in the identification of three potentially immunogenic peptides (P1 – FKRTSFFLWVIILFQRTFSIPL, P2 – LANETTQALQLF, and P3 – RATTELRTFSILNRKAIDF). An analysis to estimate the number of expected human leukocyte antigen (HLA) responders revealed that P1, P2, and P3 can potentially interact with 2540, 2150, and 2802 HLA alleles, respectively. Further, these peptides were subject to in vitro analysis wherein the human peripheral blood mononuclear cell proliferation and interferon‐gamma (IFN‐γ) production by peptide stimulated cells was studied in 10 healthy human blood samples with the help of a 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) assay and a sandwich enzyme‐linked immunosorbent assay (ELISA) respectively. P3 presented the best results, a significant (P < 0.05) peptide induced cell proliferation and IFN‐γ stimulation for 8 and 10 samples, respectively, followed by P1 (5 and 6) and P2 (5 and 7). The in silico and in vitro results obtained in this study indicate the immunogenic potential of these peptides and warrant exploration of the effects on other cytokines as well as in vivo experimental validation.
Sexual (in)equality? A meta‐analysis of sex differences in thermal acclimation capacity across ectotherms
Authors: Pottier Patrice , Burke Samantha , Drobniak Szymon M. , Lagisz Malgorzata , Nakagawa Shinichi 
Published: August 2021

Abstract

Climate change is putting the fate of ectothermic animals at stake because their body temperature closely tracks environmental temperatures. The ability to adjust thermal limits and preference through acclimation (i.e. acclimation capacity) may compensate for temperature changes. However, although necessary for forecasting the future of ectotherms in a changing climate, knowledge on the factors modulating these plastic responses is fragmentary. For instance, the influence of an animal's sex in driving acclimation capacity has been underappreciated.

Here, we present the first systematic review and meta‐analysis on sex differences in thermal acclimation capacity. Using 239 effect sizes from 37 studies and 44 species, we revealed that males and females did not differ significantly in their overall capacity to acclimate their thermal limits and preference. However, in some instances, females expressed significantly greater plastic responses than males.

In wild animals, females had a greater heat tolerance plasticity than males. In addition, females had a greater cold tolerance plasticity in terrestrial habitats, but the strength and direction of this sexual dimorphism was associated with the duration of acclimation. We also found a negative correlation between body mass and plasticity. Finally, we demonstrated that the capacity for each sex to adjust their thermal tolerance and preference was remarkably limited.

It is important to acknowledge that the above effects were weak and heterogeneous. Hence, in the species we investigated, minor differences in acclimation capacity may not translate into major ecological mismatch between sexes with climate change.

Our systematic review also revealed that over 75% of the studies we identified either did not report or confounded the sex of the animals. This under‐reporting may cause to overlook ecologically relevant sex differences in plasticity in ectothermic taxa. We stress the need for further research on sex‐based responses to temperatures.

Our synthesis provides additional evidence that the capacity for ectotherms to acclimate to temperatures is limited, and likely insufficient to compensate for the impacts of climate change.

A free Plain Language Summary can be found within the Supporting Information of this article.
Nimodipine reduces delayed cerebral vasospasm after intracranial tumour surgery: A Retrospective Study
Authors: Yu Ying , Li Yunqian , Jin Zheng , Zhao Shuai , Xie Xuan , Chen Fan 
Published: August 2021

AbstractCerebral vasospasm (CVS) is a frequent and serious neurosurgical complication, without sufficient therapy. This retrospective study was performed to analyze if nimodipine can improve prognosis and reduce ischaemia secondary to delayed CVS after intracranial tumour surgery. A retrospective review was performed over the years 2011 to 2012 for patients with an anterior cranial fossa tumour and underwent intracranial tumour surgery. The surgical field was soaked with nimodipine solution or normal saline. Transcranial Doppler ultrasonography was used to measure velocity in the middle cerebral artery (MCA) and the distal extracranial internal carotid artery (eICA). Follow‐up was performed using the Glasgow Outcome Scale (GOS) after discharge. There were 94 patients that met the inclusion criteria. They included 50 males and 44 females, with a mean age of 49.6 years. In the nimodipine group, CVS occurred in 13 patients; 9 patients had CVS between 4 and 7 days, and 4 had CVS between 8 and 14 days. In the normal saline group, 19 patients had CVS, 3 presented with CVS within 3 days, 11 between 4–7 days and 5 between 8–14 days. A significant difference in the occurrence of CVS was observed between the two groups. Preoperative and postoperative the MCA velocities were compared, revealing a significant change in the normal saline group but not in the nimodipine group. Nimodipine markedly improves prognosis and significantly reduces ischaemia secondary to delayed CVS after intracranial tumour surgery, as well as the risks of mortality and morbidity.
The effects of mirabegron on obesity‐induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue
Authors: Peres Valgas da Silva Carmem , Calmasini Fabiano , Alexandre Eduardo Costa , Raposo Helena Fonseca , Delbin Maria Andreia , Monica Fabiola Zakia , Zanesco Angelina 
Published: August 2021

AbstractMirabegron is a selective β₃‐adrenergic receptors agonist, which has been recently shown to improve metabolic health in rodents and humans. In this study, we investigated the effects of 2‐week mirabegron treatment on the metabolic parameters of mice with a diet‐induced obesity (DIO). C57BL/6JUnib mice were divided into control (CTR) and obese (OB) groups treated with vehicle, and an OB group treated with mirabegron (OB + MIRA). The obese groups were fed a high‐fat diet for 12 weeks. Mirabegron (10 mg/kg/day) was administrated orally by gavage from weeks 10–12. After 2 weeks of mirabegron treatment, the energy expenditure was assessed with indirect calorimetry. Blood glucose, insulin, glycerol, free fatty acids (FFA), thiobarbituric acid reactive substance (TBAR), and tumour necrosis factor (TNF)‐α levels were also assessed, and the HOMA index was determined. Liver tissue, brown adipose tissue (BAT), and inguinal white adipose tissue (iWAT) samples were collected for histological examination. The protein expressions of uncoupling protein 1 (UCP1) and mitochondrial transcription factor A (TFAM) were assessed using western blotting of the BAT and iWAT samples. In this study, mirabegron increased the energy expenditure and decreased adiposity in OB + MIRA. Increased UCP1 expression in BAT without changes in iWAT was also found. Mirabegron decreased circulating levels of FFA, glycerol, insulin, TNF‐α, TBARS and HOMA index. DIO significantly increased the lipid deposits in the liver and BAT, but mirabegron partially reversed this change. Our findings indicate that treatment with mirabegron decreased inflammation and improved metabolism in obese mice. This effect was associated with increased BAT‐mediated energy expenditure, but not iWAT beiging, which suggests that mirabegron might be useful for the treatment of obesity and diabetes.
Medicinal Cannabis Prescribing: A Study of Boundary Work and Medico‐Legal Risk
Authors: Case Paula 
Published: August 2021

AbstractThe prescription of ‘unlicensed’ cannabis‐based medicines was legalised in 2018. A ‘boundary work’ analysis of the post reform guidance issued for doctors reveals a discourse which frames the prescription of medicinal cannabis as a matter for clinical judgement, but also as fraught with medico‐legal hazard. The article highlights a triad of rhetorical devices comprising the ‘last resort’ principle, ‘personal responsibility’ and the randomised controlled trial as an exclusive measure of ‘safety and efficacy’. Having identified a pronounced signalling of medico‐legal risk which is likely to have a chilling effect on prescribing, this article explores how the Bolam‐Bolitho formulation of the legal standard of care in negligence litigation might respond to this new domain of prescribing. This article concludes with observations about the compatibility of innovative prescribing of unlicensed cannabis medicines with the standard of care in negligence law, notwithstanding the extreme caution inherent in the interim prescribing guidance.
Evaluation of distance‐based approaches for forensic comparison: Application to hand odor evidence
Authors: Rivals Isabelle , Sautier Cédric , Cognon Guillaume , Cuzuel Vincent 
Published: August 2021

AbstractThe issue of distinguishing between the same‐source and different‐source hypotheses based on various types of traces is a generic problem in forensic science. This problem is often tackled with Bayesian approaches, which are able to provide a likelihood ratio that quantifies the relative strengths of evidence supporting each of the two competing hypotheses. Here, we focus on distance‐based approaches, whose robustness and specifically whose capacity to deal with high‐dimensional evidence are very different, and need to be evaluated and optimized. A unified framework for direct methods based on estimating the likelihoods of the distance between traces under each of the two competing hypotheses, and indirect methods using logistic regression to discriminate between same‐source and different‐source distance distributions, is presented. Whilst direct methods are more flexible, indirect methods are more robust and quite natural in machine learning. Moreover, indirect methods also enable the use of a vectorial distance, thus preventing the severe information loss suffered by scalar distance approaches. Direct and indirect methods are compared in terms of sensitivity, specificity, and robustness, with and without dimensionality reduction, with and without feature selection, on the example of hand odor profiles, a novel and challenging type of evidence in the field of forensics. Empirical evaluations on a large panel of 534 subjects and their 1690 odor traces show the significant superiority of the indirect methods, especially without dimensionality reduction, be it with or without feature selection.
Dynamics of long‐term continuous culture of Limnospira indica in an air‐lift photobioreactor
Authors: Garcia‐Gragera David , Peiro Enrique , Arnau Carolina , Cornet Jean‐François , Dussap Claude‐Gilles , Godia Francesc 
Published: August 2021

SummaryMELiSSA (Microecological Life Support System Alternative) is a developing technology for regenerative life support to enable long‐term human missions in Space and has developed a demonstration Pilot Plant. One of the components of the MELiSSA Pilot Plant system is an 83L external loop air‐lift photobioreactor (PBR) where Limnospira indica (previously named Arthrospira sp. PC8005) is axenically cultivated in a continuous operation mode for long‐periods. Its mission is to provide O2 and consume CO2 while producing edible material. Biological and process characterization of this PBR is performed by analysing the effect of two main variables, dilution rate (D) and PFD (Photon Flux Density) illumination. A maximum oxygen productivity () of 1.35 mmol l−1 h−1 is obtained at a D of 0.025 h−1 and PFD of 930 µmol m−2 s−1. Photoinhibition can occur when a 1 g l−1 cell density culture is exposed to PFD higher than 1700 µmol m−2 s−1. This process is reversible if the illumination is returned to dim light (150 µmol m−2 s−1), proving the cell adaptability and capacity to respond at different illumination conditions. Influence of light intensity in cell composition is also described. Specific photon flux density (qPFD) has a direct effect on phycobiliproteins and chlorophyll content causing a decrease of 62.5% and 47.8%, respectively, when qPFD increases from 6.1 to 19.2 µmol g−1 s−1. The same trend is observed for proteins and the opposite for carbohydrate content. Morphological and spiral structural features of L. indica are studied by confocal microscopy, and size distribution parameters are quantified. A direct effect between trichome width and CDW/OD ratio is observed. Changes in size distribution are not correlated with environmental factors, further confirms the adaptation capacity of the cells. The systematic analysis performed provides valuable insights to understand the key performance criteria of continuous culture in air‐lift PBRs.
Brazil and BRICS Multilateralism à la Carte: From Bilateralism to Community Interest
Authors: Vazquez Karin Costa 
Published: August 2021

AbstractAs BRICS advances into its second decade of existence, it transitions from a multilateral alignment to bilateral arrangements among the five members. This ‘bi‐lateralization’ of BRICS expands the ‘menu’ of the BRICS ‘multilateralism à la carte’ by allowing members to limit cooperation when their interests diverge and to benefit from collective action through BRICS when their interests converge. This paper argues that, from the standpoint of countries like Brazil, the India–China border dispute and broader competition in the Indo‐Pacific demonstrate the ‘bi‐lateralization’ of intra‐BRICS relations as they thwart the development of a common narrative on issues like global health, security and trade. Contrarily, the bi‐lateralization of BRICS also gives members more flexibility as they manage various domestic and international challenges, which is crucial for the grouping’s survival. The experience of the BRICS‐led New Development Bank (NDB) illustrates how the five countries can still cooperate as a coalition in pursuit of common objectives such as sustainable development and infrastructure. The lack of robust mechanisms to realize these objectives, however, raises questions about NDB’s capacity to help BRICS to cooperate more like a community.