bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corneal Stability and Visual Acuity 1 Year After Corneal Cross-linking Assessed Using the ABCD Keratoconus Staging System
Authors: Danesh Zeynab , Sedaghat Mohammad-Reza , Momeni-Moghaddam Hamed , Yekta Abbas-Ali , Belin Michael W. 
Published: October 2021

PURPOSE:
To assess corneal stability and corrected distance visual acuity (CDVA) 3, 6, and 12 months following corneal cross-linking (CXL) using the ABCD keratoconus staging system.

METHODS:
This prospective longitudinal study included 31 eyes with keratoconus receiving CXL based on the standard Dresden protocol. CDVA, refraction, and Scheimpflug tomography with the Pentacam HR (Oculus Optikgeräte GmbH) were evaluated before and after surgery. Geometric and functional changes were assessed using the actual values and staging of each element of the ABCD keratoconus staging system. A, B, C, and D refer to the anterior and posterior radii of curvature in a 3-mm zone centered on the cor-neal thinnest point, minimum corneal thickness, and CDVA, respectively.

RESULTS:

There were no significant changes in the actual values of anterior radius of curvature (
P
= .497) and CDVA (
P
= .082), whereas posterior radius of curvature (
P
= .007) and corneal thinnest point (
P
< .001) showed significant changes statistically. Pairwise comparison showed only a statistically significant steepening in posterior radius of curvature at 3 months after CXL compared to the preoperative radius (
P
= .002) and a significant decrease in corneal thinnest point at 3 (
P
< .001) and 6 (
P
= .028) months after CXL compared to baseline assessment. Staging of each element of the ABCD keratoconus staging system indicated no change between baseline and 3, 6, and 12 months after CXL.

CONCLUSIONS:
The geometric and functional parameters included in the ABCD keratoconus staging system showed stability of corneal status and CDVA 1 year after CXL.

[
J Refract Surg
. 2021;37(10):700–706.]
Barriers to Follow-Up Retinal Care During the COVID-19 Pandemic: A Survey Study
Authors: Shields Charlotte N. , Cherkas Elliot G. , Mokhashi Nikita , Cai Louis Z. , Pandit Ravi R. , Patel Samir N. , Hsu Jason , Kuriyan Ajay E. , Klufas Michael A. , Ho Allen C. 
Published: October 2021

BACKGROUND AND OBJECTIVE:
To characterize patient-identified barriers to care in those non-compliant with retina appointments during the coronavirus disease 2019 (COVID-19) pandemic.

PATIENTS AND METHODS:

Inclusion criteria included non-compliant patients from March 1, 2020 to May 1, 2020. Ultimately, 1,345 patients were invited to complete a 14-question survey. A retrospective chart review correlated clinical and demographic information. Univariate logistic regression, independent-samples
t
-test, and Pearson correlation coefficient identified differences among subgroups.

RESULTS:

Of the 1,345 patients, 181 (13.5%) completed the survey. The most significant barriers to care included fear of COVID (76/181; 42.0%), wait times (21/181; 11.6%), and costs (11/181; 6.1%). Patients who got their COVID information from the Centers for Disease Control and Prevention (7.8 ± 2.4) and televised news (8.0 ± 2.0) had higher levels of fear. Finally, patients with diabetic retinopathy and higher Charlson Comorbidity Index scores had greater concerns of COVID (
P
= .034 and
P
= .047, respectively).

CONCLUSION:
This survey study suggests fear of COVID-19 is a prominent new barrier to retinal care. Identifying those at risk for loss to follow-up can guide practices as the pandemic continues.

[
Ophthalmic Surg Lasers Imaging Retina
. 2021;52:526–533.]
Predicting Post-Cataract Surgery Visual Acuity in Vitrectomized Eyes: The Efficacy and Accuracy of “Lambda” Retinometry
Authors: Mimouni Michael , Israeli Asaf , Shapira Yinon , Socea Sergiu D. , Blumenthal Eytan Z. , Zayit-Soudry Shiri 
Published: October 2021

BACKGROUND AND OBJECTIVE:
Determine the ability of Lambda retinometry to predict post-cataract surgery visual acuity in vitrectomized eyes.

PATIENTS AND METHODS:
Prospective study including 47 cataract surgery candidates with a history of pars plana vitrectomy (PPV). Lambda retinometry using a hand-held Lambda retinometer and best-corrected visual acuity (BCVA) were measured preoperatively, and BCVA was reassessed postoperatively.

RESULTS:

Lambda predictions strongly correlated with postoperative BCVA (logarithm of the minimum angle of resolution [logMAR]) (
P
< .001,
r
2
= 0.57), especially combined with preoperative BCVA (logMAR) (
P
< .001,
r
2
= 0.65). In 89% of cases, postoperative BCVA was equal to or higher than the prediction. Neither cataract grades nor indications for PPV were associated with the accuracy of Lambda predictions (
P
= .882 and
P
= .790, respectively). Underestimation of visual outcome was more common than overestimation. A Lambda prediction of ≥ 20/40 (Snellen) had a positive predictive value of 85.7% and a negative predictive value of 73.6% for the postoperative outcome.

CONCLUSIONS:
Lambda retinometry can reliably predict the postoperative BCVA in cataract patients who previously underwent PPV, with a tendency towards underestimation.

[
Ophthalmic Surg Lasers Imaging Retina
. 2021;52:535–542.]
A Modified Surgical Technique for Submacular Injection
Authors: Ohayon Avi , Schwartz Shulamit , Loewenstein Anat , Seknazi Daniel , Souied Eric H. , Barak Adiel 
Published: October 2021

BACKGROUND AND OBJECTIVE:
To describe a modified simple surgical technique for submacular injection.

PATIENTS AND METHODS:
The technique involves pars plana vitrectomy, a viscous fluid control (VFC) system for semi-automatic subretinal injection of tissue plasminogen activator (tPA), bevacizumab, and air and intravitreal gas injection for submacular hemorrhage (SMH), or subretinal balanced salt solution (BSS) for submacular perfluorocarbon (PFC) bubbles or persistent macular holes.

RESULTS:
This technique was successfully performed for SMH (five patients), a subfoveal PFC bubble (two patients), and persistent full-thickness macular hole (FTMH) (one patient). The single surgical complication was an FTMH in a PFC bubble. Four SMH patients had postoperative displacement of the hemorrhage. The FTMH was partially closed.

CONCLUSIONS:
Semi-automatic subretinal injection of tPA, bevacizumab, and air with the VFC system promoted displacement and clearance of SMH without complications. A subretinal BSS injection is effective for removing subfoveal PFC bubbles and for closing persistent FTMH.

[
Ophthalmic Surg Lasers Imaging Retina
. 2021;52:551–555.]
Geospatial Distribution of Ophthalmologists Older than Age 60 Years Relative to the Prevalence of COVID-19
Authors: Rasendran Chandruganesh , Haueisen Alexander J. , Wadhwa Raoul , Singh Rishi P. 
Published: October 2021

BACKGROUND AND OBJECTIVE:
To evaluate coronavirus disease 2019 (COVID-19) cases as of February 1, 2021 and the proportion of ophthalmologists in the United States older than age 60 years to provide a framework for successful vaccine distribution for the ophthalmology workforce.

PATIENTS AND METHODS:
The Association of American Medical Colleges ophthalmologist workforce dataset (from 2019) for each state was combined with John Hopkins University's COVID-19 tracking data to determine exposure risk for ophthalmologists, especially those older than age 60 years.

RESULTS:
Of the 18,915 practicing ophthalmologists in the US, 37.6% are older than age 60 years. North Dakota (48.4%), Connecticut (46.8%), and Maine (46.7%) have the highest percentages. South Dakota (9,567), Utah (7,559), and Idaho (7,411) currently have the highest COVID-19 exposure burden per ophthalmologist older than age 60 years as of February 1, 2021.

CONCLUSION:
Care must be taken to distribute the COVID-19 vaccine in a safe and proactive manner to ophthalmologists that face high exposure risk, both to ensure physician safety and ensure adequate care for the population they serve.

[
Ophthalmic Surg Lasers Imaging Retina
. 2021;52:556–559.]
Maternal Monocytes Respond to Cell-Free Fetal DNA and Initiate Key Processes of Human Parturition
Authors: Yeganeh Kazemi Nazanin , Fedyshyn Bohdana , Sutor Shari , Fedyshyn Yaroslav , Markovic Svetomir , Enninga Elizabeth Ann L 
Published: October 2021

Abstract
Throughout gestation, the maternal immune system is tightly modulated to allow growth of a semiallogeneic fetus. During the third trimester, the maternal immune system shifts to a proinflammatory phenotype in preparation for labor. What induces this shift remains unclear. Cell-free fetal DNA (cffDNA) is shed by the placenta and enters maternal circulation throughout pregnancy. Levels of cffDNA are increased as gestation progresses and peak before labor, coinciding with a shift to proinflammatory maternal immunity. Furthermore, cffDNA is abnormally elevated in plasma from women with complications of pregnancy, including preterm labor. Given the changes in maternal immunity at the end of pregnancy and the role of sterile inflammation in the pathophysiology of spontaneous preterm birth, we hypothesized that cffDNA can act as a damage-associated molecular pattern inducing an inflammatory cytokine response that promotes hallmarks of parturition. To test this hypothesis, we stimulated human maternal leukocytes with cffDNA from primary term cytotrophoblasts or maternal plasma and observed significant IL-1β and CXCL10 secretion, which coincides with phosphorylation of IFN regulatory factor 3 and caspase-1 cleavage. We then show that human maternal monocytes are crucial for the immune response to cffDNA and can activate bystander T cells to secrete proinflammatory IFN-γ and granzyme B. Lastly, we find that the monocyte response to cffDNA leads to vascular endothelium activation, induction of myometrial contractility, and PGE2 release in vitro. Our results suggest that the immune response to cffDNA can promote key features of the parturition cascade, which has physiologic consequences relevant to the timing of labor.
Associations between Diabetes Mellitus and Nontuberculous Mycobacterium-Caused Diseases in Taiwan: A Nationwide Cohort Study
Authors: Wang Jui-Yang , Lin Hsin-Chung , Lin Hsin-An , Chung Chi-Hsiang , Chen Lih-Chyang , Huang Kuo-Yang , Sun Chien-An , Chien Wu-Chien , Guo Jong-Long 
Published: October 2021

ABSTRACT.
Patients with diabetes mellitus (DM) are at greater risk of developing active tuberculosis and other intracellular bacterial infections, although the risk of acquiring infections from nontuberculous Mycobacterium (NTM) remains undefined. This study evaluated associations between DM and incidence of NTM infection-caused pulmonary and cutaneous diseases. Data for DM patients were extracted from the National Health Insurance Research Database of Taiwan. The DM cohort included 136,736 patients, and cases were matched randomly by age, gender, and index year with non-DM patients. Multivariate Cox proportional hazards regression was used to calculate adjusted hazard ratios of incident NTM-caused diseases in the DM cohort compared with non-DM control subjects. The frequency of incident NTM-caused diseases was significantly greater in DM patients (0.12%) than in non-DM patients (0.08%) (P < 0.05), including patients with type 1 DM (0.12%) and type 2 DM (0.12%) (all P < 0.05). Adjusted multivariate Cox regression analysis revealed that the incidence of NTM-caused diseases in DM patients was 1.43-fold greater than that in non-DM patients overall (P < 0.05), particularly in pulmonary (1.13-fold), other specific (excluding pulmonary, cutaneous, and disseminated diseases; 3.88-fold), and unspecific (atypical NTM infection; 1.54-fold) diseases (all P < 0.05). In conclusion, both type 1 DM and type 2 DM patients have high risk of NTM-caused diseases, suggesting that physicians need to pay more attention to this issue concerning the high risk of NTM-caused infection in DM patients.
Causes and Outcomes of Admission and Investigation of Tuberculosis in Adults with Advanced HIV in South African Hospitals: Data from the TB Fast Track Trial
Authors: Beckwith Peter G. , Tlali Mpho , Charalambous Salome , Churchyard Gavin J. , Fielding Katherine L. , Hoffmann Christopher J. , Johnson Suzanne , Wood Natalie , Grant Alison D. , Karat Aaron S. 
Published: October 2021

ABSTRACT.
Tuberculosis (TB) remains the leading cause of hospitalization and in-hospital mortality in HIV-positive adults. Using data from hospital and clinic files, research databases, and autopsy, we describe causes and outcomes of admissions, and assess investigations for TB among adults with advanced HIV who were hospitalized after enrollment into the TB Fast Track trial in South Africa (2013–2015). A total of 251 adults [median CD4 count, 37.5 cells/μL; interquartile range, 14–68 cells/µL; 152 (60.6%) on antiretroviral therapy] experienced 304 admissions. Ninety-five of 251 of the first admissions (37.8%) were TB related; the next most common causes were AIDS-related illnesses (41 of 251, 16.3%) and surgical causes (21 of 251, 8.4%). Of those admitted with previously undiagnosed TB, 60% had CD4 counts less than 50 cells/µL. Overall, 137 of 251 individuals died as inpatients or within 90 days of their first discharge. Case fatality rates were particularly high for those admitted with TB (66%) and bacterial infections (80%). In 144 admissions for whom anti-TB treatment had not been started before admission, a sputum-based TB investigation was recorded in only 12 of 57 admissions (21.1%) in whom one or more TB symptom was recorded (24 of 57 started on treatment), and 6 of 87 admissions (6.9%) in whom no TB symptoms were recorded (14 of 87 started on treatment). Hospitalized adults with advanced HIV are at high risk of death. TB was a common cause of hospitalization but was under-investigated, even in those with symptoms. In addition to early identification of TB and other AIDS-related illnesses during hospitalization of adults with advanced HIV, improved pre-hospital management strategies are needed to interrupt disease progression and reduce poor outcomes in this already vulnerable population.
Taenia solium Metacestode Factor as Probable Cause of Temporal Lobe Epilepsy
Authors: Molinari José L. 
Published: October 2021

ABSTRACT.
This article analyzes data from scientific publications (mainly reviews) concerning the link between human neurocysticercosis and epilepsy. Along with data from our own studies on experimental hippocampal sclerosis induced by a Taenia crassiceps metacestode factor in mice, it explores the connection between mechanisms that likely favor the development of epilepsy in cases of human neurocysticercosis. The data from both sources suggest the idea that the T. solium metacestode factor causes hippocampal sclerosis and later epilepsy in humans with neurocysticercosis.
CÁC YẾU TỐ ẢNH HƯỞNG ĐẾN Ý ĐỊNH SỬ DỤNG HÓA ĐƠN ĐIỆN TỬ CỦA DOANH NGHIỆP TẠI CHI CỤC THUẾ QUẬN TÂN PHÚ – TP.HCM
Authors: TUẤN NGUYỄN MINH , CHÂU ĐỖ VIỄN 
Published: October 2021

Nội dung chính của nghiên cứu là tìm hiểu và xác định các yếu tố chính ảnh hưởng đến ý định sử dụng hóa đơn điện tử của doanh nghiệp tại Chi Cục Thuế quận Tân Phú TP.HCM. Trong nghiên cứu, tác giả đề xuất mô hình nghiên cứu gồm 6 yếu tố là tính hữu ích (HI), dễ sử dụng (SD), tính tương hổ (TH), chi phí (CP), sự tin tưởng (TT), chuẩn chủ quan (CQ). Kết quả nghiên cứu có 6 yếu tố ảnh hưởng đến ý định sử dụng hóa đơn điện tử của doanh nghiệp tại Chi Cục Thuế quận Tân Phú TP.HCM theo mức độ ảnh hưởng từ cao đến thấp là tính hữu ích, dễ sử dụng, chuẩn chủ quan, sự tin tưởng, tính tương hổ
CÁC YẾU TỐ ẢNH HƯỞNG ĐẾN LÒNG TRUNG THÀNH CỦA NHÂN VIÊN ĐỐI VỚI CÔNG TY TNHH ĐIỆN THÀNH VINH
Authors: HÙNG MAI THANH , KIÊN ĐẶNG TRUNG 
Published: October 2021

Bài báo này nhằm mục đích nhận diện các yếu tố ảnh hưởng đến lòng trung thành của nhân viên công ty TNHH Điện Thành Vinh đối với tổ chức và đưa ra các giải pháp giúp xây dựng lòng trung thành của nhân viên. Dựa trên phương pháp phân tích dữ liệu như phân tích Cronbach’s alpha, phân tích EFA và phân tích hồi quy bội từ đó đo lường mức độ ảnh hưởng các yếu tố đến lòng trung thành của nhân viên đối với công ty Điện Thành Vinh.
Các kết quả thu được từ nghiên cứu này góp phần bổ sung vào thực tiễn quản lý, giúp các nhà quản trị hiểu biết rõ hơn về công tác quản trị nguồn nhân lực, tạo được động lực để nâng cao sự trung thành của nhân viên với tổ chức nhằm duy trì nguồn lực cho doanh nghiệp.
CÁC YẾU TỐ ẢNH HƯỞNG ĐẾN GIÁ CỔ PHIẾU CỦA NHỮNG DOANH NGHIỆP BẤT ĐỘNG SẢN NIÊM YẾT TRÊN THỊ TRƯỜNG CHỨNG KHOÁN VIỆT NAM
Authors: NGỌC VÂN PHẠM 
Published: October 2021

Bài viết này nghiên cứu sự tác động của các yếu tố tỷ lệ lạm phát (INF), thu nhập trên mỗi cổ phần (EPS), cổ tức trên mỗi cổ phần (DPS) và chỉ số giá vàng (DGP) đến giá cổ phiếu (SP) tại các doanh nghiệp ngành BĐS được niêm yết trên SGDCK TP.HCM trong giai đoạn từ 2012 đến 2017.
Thông qua phương pháp xử lý dữ liệu bằng kỹ thuật hồi quy dữ liệu bảng, bài nghiên cứu tiến hành phân tích các yếu tố tác động đến giá cổ phiếu của 30 doanh nghiệp nhóm ngành BĐS được niêm yết trên SGDCK TP.HCM từ năm 2012 đến năm 2017.
Kết quả nghiên cứu chỉ ra rằng các yếu tố thu nhập trên mỗi cổ phần (EPS), cổ tức trên mỗi cổ phần (DPS) và chỉ số giá vàng (DGP) có tác động tới giá cổ phiếu (SP)
Từ kết quả đó, tác giả đưa ra một số kiến nghị giúp cho các nhà đầu tư cũng như các doanh nghiệp ngành BĐS tại Việt Nam có cái nhìn toàn diện hơn đối với các yếu tố tác động đến giá cổ phiếu của các doanh nghiệp ngành BĐS để có các quyết định phù hợp nhất.
INNOVATING CONTENT AND METHODOLOGY OF MANAGEMENT ACCOUNTING EDUCATION IN VIETNAMESE UNIVERSITIES FOR MEETING INTERNATIONAL INTEGRATION
Authors: HUYNH TANDUNG , HUYNH HUYHANH , HAI BINH LE THI 
Published: October 2021

Management accounting is a compulsory subject in the curriculum of accounting at the Vietnamese universities. This subject provides management accounting knowledge and future accounting practising skills to students. In the trend of international integration in economics and education, the role of management accounting is more and more important, it requires accounting graduates to gain professional knowledge about accounting management to meet the needs of domestic and foreign organizations. It poses a challenge for Vietnamese universities in the renewal of contents and teaching methods of management accounting subject, especially when most of the stakeholders suggest increase this subject’s credits and contents.
This paper researches the reality of management accounting teaching at the Vietnamese universities and suggests the solutions to innovate this subject’s contents and teaching methods. It helps to improve the education quality for accounting students in the trend of international integration.
Soroprevalência da doença de Chagas em cardiopatas internados em um hospital de referência da região Serrana do estado do Rio de Janeiro, Brasil.
Authors: Nielebock Marco Antonio Prates , Regazio Fernanda Mello , Mendes Mônica , Santos Renan Rocha , Figueredo Leila Neto , Sangenis Luiz Henrique Conde 
Published: October 2021

Objetivo: o objetivo deste estudo foi estimar a soroprevalência da doença de Chagas em cardiopatas internados em um hospital de referência da região Serrana do Rio de Janeiro e identificar fatores de risco para transmissão da doença. Material e Métodos: estudo transversal, descritivo, com utilização de questionário e teste rápido para doença de Chagas. Resultados: foram estudados 209 cardiopatas, com predomínio de idosos do sexo masculino. Moradia em casas de pau a pique nas primeiras décadas de vida, conhecimento do barbeiro e o consumo de carne de caça foram fatores de risco comuns. Insuficiência cardíaca, doença arterial coronária e arritmias foram as principais causas de internação. Uma amostra se mostrou positiva para infecção por Trypanosoma cruzi (prevalência de 0,5%). Conclusão: apesar da baixa prevalência observada, a alta frequência de fatores de risco envolvidos na transmissão da doença de Chagas, serve de alerta para a vigilância epidemiológica do Rio de Janeiro.
Práticas cotidianas do recreio escolar: táticas de quem gosta de inventar
Authors: Alves Marcelo Paraiso , Rabelo Isabela Carvalho , Tuler Rosinei Maria de Oliveira , Fonseca Maria Conceição Vinciprova 
Published: October 2021

A pesquisa se configura a partir de uma pesquisa de campo que explicita a interação dos discentes, o espaço do recreio e a escola. O objetivo foi investigar as práticas socioculturais dos alunos durante o recreio escolar. Considerando que a escola é uma instituição que busca normatizar o espaçotempo dos sujeitos que se encontram sob a sua ação, cabe refletir: Será que o recreio escolar é utilizado como um espaço de criação e reinvenção de possibilidades de movimentos? Como opção metodológica nos aproximamos da etnografia para o aprofundamento nas práticas cotidianas dos durante o recreio escolar, de modo a nos inteirarmos sobre as diferentes relações existentes entre os sujeitos e sobre as diferentes ações praticadas por eles. Os resultados revelam que, embora o recreio seja um espaço controlado pela escola, ainda é concebido pelos alunos como um local favorável a diversas descobertas, portanto, aberto a possíveis problematizações e reinvenções culturais.
A multimorbidade como fator impactante no diagnóstico de Acromegalia: um relato de caso
Authors: Mol Viviane Soldati , De Almeida Fonseca Marcilene Maria , Da Fonseca Walter Luiz Moraes Sampaio 
Published: October 2021

A acromegalia é uma doença crônica resultante da disfunção hipofisária, com hipersecreção do hormônio de crescimento,alterações somáticas e diagnóstico difícil na fase inicial, mais frequentemente causada pelo adenoma hipofisário. O objetivo é descrever e discutir um caso de acromegalia em um homem de 50 anos,apresentando multimorbidades que o levaram a procurar cuidado médico. O macroadenoma hipofisário associado à acromegalia é uma patologia que deve ser conhecida, para que o diagnóstico seja feito corretamente e o mais precoce possível e assim, diminuir a morbimortalidade.
Diagnostic Evaluation of Uterine Artery Doppler Imaging for the Prediction of Early Abnormal Pregnancy
Authors: Abdulla Thikra N. , Hassan Qays A. , Abood Hawraa K. 
Published: October 2021

Objective: to assess the predictive value of Doppler imaging of the uterine artery in the identification of early intrauterine abnormal pregnancy as compared to a normal intrauterine pregnancy.
Subjects and methods: one hundred and twenty pregnant ladies, at their 6-12 weeks of gestation, with a singleton pregnancy were included in this population-based case-control study. Thirty women with a missed miscarriage, 30 with hydatidiform mole, 30 with a blighted ovum, and 30 as a control group, without risk factors, underwent Doppler interrogation of the uterine arteries. Resistive index (RI), pulsatility index (PI), and the systolic/diastolic ratio (S/D) were measured for both sides. The t-test, or ANOVA test when appropriate, was used to analyze the relationship between the variables.
Results: there was a significant reduction of RI mean, PI mean, and S/D ratio among women with different types of abnormal pregnancy compared with the control group. RI and PI mean levels were significantly lower in women with hydatidiform mole and significantly higher in women with missed miscarriage. Lower left S/D mean level was significantly associated with hydatidiform mole and upper left S/D level was associated significantly with control women. For prediction of missed miscarriage; right and left uterine artery RI shows a sensitivity of 80%, 73.3%, a specificity of 68%, 71.1%, and the highest AUC was 0.78 for both.For prediction of molar pregnancy, right and left uterine artery RI showed a sensitivity of 63% for both, a specificity of 54.4%, 60%, and the highest AUC was 0.58, 0.61 respectively.
Conclusions: Uterine artery Doppler ultrasonography at 6-12 weeks of gestation is predictive for early pregnancy complications such as missed abortion, hydatidiform mole, and blighted ovum.