bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of homocysteine levels on mortality risk in patients with chronic limb-threatening ischemia undergoing revascularization
Authors: Takahara Mitsuyoshi , Iida Osamu , Soga Yoshimitsu , Kodama Akio , Terashi Hiroto , Azuma Nobuyoshi 
Published: June 2021

AbstractThe current study aimed to reveal the clinical impact of plasma homocysteine levels in chronic limb-threatening ischemia (CLTI) patients undergoing revascularization. This was a sub-analysis of a prospective multicenter registry of CLTI patients, named the Surgical reconstruction versus Peripheral INtervention in pAtients with critical limb isCHemia (SPINACH) study. The current analysis included 192 non-dialysis-dependent CLTI patients who underwent revascularization for CLTI, and whose plasma homocysteine levels at baseline were available. The association of clinical characteristics with homocysteine levels was evaluated with the linear regression model. The association of homocysteine levels with the mortality risk was investigated using the Cox proportional hazards regression model. Cystatin C-based estimated glomerular filtration rate (eGFR) was independently associated with log-transformed homocysteine levels; the adjusted standardized regression coefficient (95% confidence interval) was − 0.432 (− 0.657 to − 0.253; P < 0.001). Homocysteine levels were significantly associated with the mortality risk in the univariate model (P = 0.017); the unadjusted hazard ratio was 1.71 (1.13–2.50) per twofold increase. The association was significantly attenuated when adjusted for cystatin C-based eGFR (P < 0.001); the hazard ratio adjusted for cystatin C-based eGFR was 1.28 (0.80–1.90; P = 0.29). An apparent association of homocysteine levels with an increased risk of mortality could be explained by renal dysfunction. Future studies will be needed to validate the current findings.
A review of proficiency exercises offered by the Veterinary Laboratory Investigation and Response Network (Vet-LIRN) and Moffett Proficiency Testing Laboratory from 2012 to 2018
Authors: Nemser Sarah , Lindemann Samantha , Chen Yang , Lopez Salvador , Pickens Shannon , Ulaszek Jodie , Kmet Matthew , Powers Christopher , Ensley Steve , Schrunk Dwayne , Rumbeiha Wilson , Tkachenko Andriy , Guag Jake , Ceric Olgica , Jones Jennifer , Reimschuessel Renate , Reddy Ravinder 
Published: June 2021

AbstractThe Food and Drug Administration’s Veterinary Laboratory Investigation and Response Network is comprised of more than 40 animal diagnostic laboratories within North America and offers voluntary Proficiency Exercises to these participating laboratories. The joint Proficiency Exercise Program is run in collaboration with the Center for Food safety and Nutrition and Institute for Food safety and Health, located at the Moffett Proficiency Testing Laboratory. From 2012 to 2018, the Proficiency Exercise Program offered 20 proficiency tests or interlaboratory comparison exercises focused on veterinary analytes of interest. The program evaluated performance of laboratories, individual analysts, and the methods used. Over the six-year period, the program improved exercise schemes, as well as offered network laboratories exercises with analytes not routinely seen such as animal tissue with naturally occurring residues. Animal diagnostic laboratories can use performance results to assist with accreditation, demonstrate proficiency, and improve diagnostic capabilities.
One-year results of a novel self-adhesive bulk-fill restorative and a conventional bulk-fill composite in class II cavities—a randomized clinical split-mouth study
Authors: Cieplik Fabian , Scholz Konstantin J. , Anthony Julian C. , Tabenski Isabelle , Ettenberger Sarah , Hiller Karl-Anton , Buchalla Wolfgang , Federlin Marianne 
Published: June 2021

Abstract
Objectives
In the context of the phase-down of amalgam, development of easily applicable, permanent restorative materials is of high clinical interest. Aim of this study was to evaluate the clinical performance of a novel, tooth-colored, self-adhesive bulk-fill restorative (SABF, 3M Oral Care) and a conventional bulk-fill composite (Filtek One, 3M Oral Care; FOBF) for restoring class II cavities. The null-hypothesis tested was that both materials perform similar regarding clinical performance.

Materials and methods
In this randomized split-mouth study, 30 patients received one SABF and one FOBF restoration each. Scotchbond Universal (3M Oral Care) was used as adhesive for FOBF (self-etch mode), while SABF was applied directly without adhesive. Restorations were evaluated by two blinded examiners at baseline, 6 months and 12 months employing FDI criteria. Non-parametric statistical analyses and χ2-tests (α = 0.05) were applied.

Results
Thirty patients (60 restorations) were available for the 6- and 12-month recalls exhibiting 100% restoration survival. All restorations revealed clinically acceptable FDI scores at all time points and for all criteria. Only regarding esthetic properties, FOBF performed significantly better than SABF regarding surface lustre (A1) and color match and translucency (A3) at all time points and marginal staining (A2b) at 12 months.

Conclusions
The null-hypothesis could not be rejected. Both materials performed similarly regarding clinical performance within the first year of clinical service. SABF exhibited slightly inferior, but clinically fully acceptable esthetic properties as compared to FOBF.

Clinical relevance
Within the limitations of this study, the self-adhesive bulk-fill restorative showed promising results and may be recommended for clinical use.
Heterogeneous Catalytic Method for the Copper(II)-Catalysed Addition of H-Phosphinates and Secondary Phosphine Oxides to Phenylacetylene
Authors: Juhász Kinga , Varga Bence , Bagi Péter , Hell Zoltán 
Published: June 2021

AbstractCopper(II) on 4 Å molecular sieve was found to be an efficient heterogeneous catalyst in the addition of different H-phosphinates and secondary phosphine oxides to phenylacetylene. All hydrophosphinylation reactions were completely regioselective, as only β-isomers were formed, and the E-alkenylphosphinates and E-alkenylphosphine oxides were synthesized in moderate to excellent yields. The catalyst could be reused multiple times in the reaction.
Graphic Abstract
Beyond the “STEM Pipeline”: Expertise, Careers, and Lifelong Learning
Authors: Skrentny John D. , Lewis Kevin 
Published: June 2021

AbstractStudies of education and careers in science, technology, engineering, and math (STEM) commonly use a pipeline metaphor to conceptualize forward movement and persistence. However, the “STEM pipeline” carries implicit assumptions regarding length (i.e. that it “starts” and “stops” at specific stages in one’s education or career), contents (i.e. that some occupational fields are “in” the pipeline while others are not), and perceived purpose (i.e. that “leakage,” or leaving STEM, constitutes failure). Using the National Survey of College Graduates, we empirically measure each of these dimensions. First, we show that a majority of STEM workers report skills training throughout their careers, suggesting no clear demarcation between education and work. Second, we show that using on-the-job expertise requirements (rather than occupational titles) paints a very different portrait of the STEM workforce—and persistence in it (where substantial attrition remains evident, especially among women and African Americans). Third, we show that STEM-educated workers are well-prepared for but dissatisfied with non-STEM jobs, complicating our understanding of leaving. Collectively, these results recommend expanded conceptions of STEM education and careers and contribute to studies of science and engineering workforce transitions and diversity.
Economic policy uncertainty and investment in Spain
Authors: Dejuan-Bitria Daniel , Ghirelli Corinna 
Published: June 2021

AbstractThe aim of this paper is to investigate the effect of economic policy uncertainty on firms’ investment decisions. We focus on Spain for the period 1998–2014. To measure policy-related uncertainty, we borrow the economic policy uncertainty (EPU) indicator available for this country. We find strong evidence that uncertainty reduces corporate investment. This relationship appears to be nonlinear, being the marginal effect of uncertainty attenuated toward zero during periods of high uncertainty levels. Furthermore, the heterogeneous results suggest that the adverse effect of uncertainty is particularly relevant for highly vulnerable firms. Overall, these results are consistent with the hypotheses that economic policy-related uncertainty reduces corporate investment through increases in precautionary savings or to worsening of credit conditions.
Incorporating dynamic flight network in SEIR to model mobility between populations
Authors: Ding Xiaoye , Huang Shenyang , Leung Abby , Rabbany Reihaneh 
Published: June 2021

AbstractCurrent efforts of modelling COVID-19 are often based on the standard compartmental models such as SEIR and their variations. As pre-symptomatic and asymptomatic cases can spread the disease between populations through travel, it is important to incorporate mobility between populations into the epidemiological modelling. In this work, we propose to modify the commonly-used SEIR model to account for the dynamic flight network, by estimating the imported cases based on the air traffic volume and the test positive rate. We conduct a case study based on data found in Canada to demonstrate how this modification, called Flight-SEIR, can potentially enable (1) early detection of outbreaks due to imported pre-symptomatic and asymptomatic cases, (2) more accurate estimation of the reproduction number and (3) evaluation of the impact of travel restrictions and the implications of lifting these measures. The proposed Flight-SEIR is essential in navigating through this pandemic and the next ones, given how interconnected our world has become.
A novel big data approach to measure and visualize urban accessibility
Authors: Jiang Yuqin , Guo Diansheng , Li Zhenlong , Hodgson Michael E. 
Published: June 2021

AbstractAccessibility is a topic of interest to multiple disciplines for a long time. In the last decade, the increasing availability of data may have exceeded the development of accessibility modeling approaches, resulting in a modeling gap. In part, this modeling gap may have resulted from the differences needed for single versus multimodal opportunities for access to services. With a focus on large volumes of transportation data, a new measurement approach, called Urban Accessibility Relative Index (UARI), was developed for the integration of multi-mode transportation big data, including taxi, bus, and subway, to quantify, visualize and understand the spatiotemporal patterns of accessibility in urban areas. Using New York City (NYC) as the case study, this paper applies the UARI to the NYC data at a 500-m spatial resolution and an hourly temporal resolution. These high spatiotemporal resolution UARI maps enable us to measure, visualize, and compare the variability of transportation service accessibility in NYC across space and time. Results demonstrate that subways have a higher impact on public transit accessibility than bus services. Also, the UARI is greatly affected by diurnal variability of public transit service.
The influence of exposure to violence on adolescents’ physical aggression: The protective influence of peers
Authors: Coleman Jasmine N. , Farrell Albert D. 
Published: June 2021

ABSTRACTIntroductionThis study examined the degree to which peers can serve as a protective factor to mitigate the negative effects of exposure to violence (i.e., victimization, witnessing violence) on adolescents' physical aggression. Four specific dimensions of peer influence were examined — friends' support for nonviolence, friends' support for fighting, peer pressure for fighting, and friends’ delinquent behavior.MethodsAnalyses were conducted on four waves of data collected every 3 months (i.e., fall, winter, spring, summer) from a predominantly African‐American (78%) sample of 2575 sixth, seventh, and eighth graders attending three public middle schools in the United States. The sample was 52% female, with a mean age of 12.3 years (SD = 1.00).ResultsFindings for relations with victimization differed by sex. For boys, low levels of friends' delinquent behavior attenuated the relation between victimization and changes in physical aggression across all three waves. The protective effect of low levels of peer pressure for fighting was only evident in the winter for boys, whereas the protective effect of friends' support for nonviolence was only evident in the summer. For girls, high levels of friends’ support for nonviolence attenuated the relation between victimization in the winter and changes in physical aggression in the spring. In contrast, none of the peer factors moderated the relation between witnessing violence and physical aggression.ConclusionsFindings suggest that prevention and interventions that increase positive peer influences and decrease negative peer influences may benefit adolescents by reducing risks associated with victimization.
Fabrication of disk-shaped, deuterated resorcinol/formaldehyde foam target for laser–plasma experiments
Authors: Kaneyasu Yumi , Nagai Keiji , Cadatal-Raduban Marilou , Golovin Daniil , Shokita Satoshi , Yogo Akifumi , Jitsuno Takahisa , Norimatsu Takayoshi , Yamanoi Kohei 
Published: June 2021

Abstract
Resorcinol/formaldehyde (RF) foam resin is an attractive material as a low-density target in high-power laser–plasma experiments because of its fine network structure, transparency in the visible region, and low-Z element (hydrogen, carbon, and oxygen) composition. In this study, we developed disk-shaped RF foam and deuterated RF foam targets with 40–200 μm thickness and approximately 100 mg/cm3 density having a network structure from 100 nm to a few micrometers cell size. By deuteration, the polymerization rate was drastically slowed down owing to kinetic isotope effects. These targets were used in high-power laser experiments where a megaelectronvolt proton beam was successfully generated.
Autonomic activity, posttraumatic and nontraumatic nightmares, and PTSD after trauma exposure
Authors: Mäder Thomas , Oliver Katelyn I. , Daffre Carolina , Kim Sophie , Orr Scott P. , Lasko Natasha B. , Seo Jeehye , Kleim Birgit , Pace-Schott Edward Franz 
Published: June 2021

AbstractBackgroundNightmares are a hallmark symptom of posttraumatic stress disorder (PTSD). This strong association may reflect a shared pathophysiology in the form of altered autonomic activity and increased reactivity. Using an acoustic startle paradigm, we investigated the interrelationships of psychophysiological measures during wakefulness and PTSD diagnosis, posttraumatic nightmares, and nontraumatic nightmares.MethodsA community sample of 122 trauma survivors were presented with a series of brief loud tones, while heart rate (HRR), skin conductance (SCR), and orbicularis oculi electromyogram (EMGR) responses were measured. Prior to the tone presentations, resting heart rate variability (HRV) was assessed. Nightmares were measured using nightmare logs. Three dichotomous groupings of participants were compared: (1) current PTSD diagnosis (n= 59), no PTSD diagnosis (n= 63), (2) those with (n= 26) or without (n= 96) frequent posttraumatic nightmares, and (3) those with (n= 22) or without (n= 100) frequent nontraumatic nightmares.ResultsPTSD diagnosis was associated with posttraumatic but not with nontraumatic nightmares. Both PTSD and posttraumatic nightmares were associated with a larger mean HRR to loud tones, whereas nontraumatic nightmare frequency was associated with a larger SCR. EMGR and resting HRV were not associated with PTSD diagnosis or nightmares.ConclusionsOur findings suggest a shared pathophysiology between PTSD and posttraumatic nightmares in the form of increased HR reactivity to startling tones, which might reflect reduced parasympathetic tone. This shared pathophysiology could explain why PTSD is more strongly related to posttraumatic than nontraumatic nightmares, which could have important clinical implications.
The role of corrective feedback and lexical guidance in perceptual learning of a novel L2 accent in dialogue
Authors: Felker Emily , Broersma Mirjam , Ernestus Mirjam 
Published: June 2021

AbstractPerceptual learning of novel accents is a critical skill for second-language speech perception, but little is known about the mechanisms that facilitate perceptual learning in communicative contexts. To study perceptual learning in an interactive dialogue setting while maintaining experimental control of the phonetic input, we employed an innovative experimental method incorporating prerecorded speech into a naturalistic conversation. Using both computer-based and face-to-face dialogue settings, we investigated the effect of two types of learning mechanisms in interaction: explicit corrective feedback and implicit lexical guidance. Dutch participants played an information-gap game featuring minimal pairs with an accented English speaker whose /ε/ pronunciations were shifted to /ɪ/. Evidence for the vowel shift came either from corrective feedback about participants’ perceptual mistakes or from onscreen lexical information that constrained their interpretation of the interlocutor’s words. Corrective feedback explicitly contrasting the minimal pairs was more effective than generic feedback. Additionally, both receiving lexical guidance and exhibiting more uptake for the vowel shift improved listeners’ subsequent online processing of accented words. Comparable learning effects were found in both the computer-based and face-to-face interactions, showing that our results can be generalized to a more naturalistic learning context than traditional computer-based perception training programs.
War and peace in liberated North Korea: Soviet military administration and the creation of North Korean police force in 1945
Authors: Lebedev Vasilii 
Published: June 2021

AbstractThe North Korean police were arguably one of the most important organisations in liberated North Korea. It was instrumental in stabilising the North Korean society and eventually became one of the backbones for both the new North Korean regime and its military force. Scholars of different political orientation have attempted to reconstruct its early history leading to a set of views ranging from the “traditionalist” sovietisation concept to the more contemporary “revisionist” reconstruction that portrayed it as the cooperation of North Korean elites with the Soviet authorities in their bid for the control over the politics and the military, in which the Soviets merely played the supporting role. Drawing from the Soviet archival documents, this paper presents a third perspective, arguing that initially, the Soviet military administration in North Korea did not pursue any clear-cut political goals. On the contrary, the Soviet administration initially viewed North Koreans with distrust, making Soviets constantly conduct direct interventions to prevent North Korean radicals from using the police in their political struggle.
Accounting for Transport Error in Inversions: An Urban Synthetic Data Experiment
Authors: Ghosh Subhomoy , Mueller Kimberly , Prasad Kuldeep , Whetstone James 
Published: June 2021

AbstractWe present and discuss the use of a high‐dimensional computational method for atmospheric inversions that incorporates the space‐time structure of transport and dispersion errors. In urban environments, transport and dispersion errors are largely the result of our inability to capture the true underlying transport of greenhouse gas (GHG) emissions to observational sites. Motivated by the impact of transport model error on estimates of fluxes of GHGs using in situ tower‐based mole‐fraction observations, we specifically address the need to characterize transport error structures in high‐resolution large‐scale inversion models. We do this using parametric covariance functions combined with shrinkage‐based regularization methods within an Ensemble Transform Kalman Filter inversion setup. We devise a synthetic data experiment to compare the impact of transport and dispersion error component of the model‐data mismatch covariance choices on flux retrievals and study the robustness of the method with respect to fewer observational constraints. We demonstrate the analysis in the context of inferring CO2 fluxes starting with a hypothesized prior in the Washington D.C. /Baltimore area constrained by a synthetic set of tower‐based CO2 measurements within an observing system simulation experiment framework. This study demonstrates the ability of these simple covariance structures to substantially improve the estimation of fluxes over standard covariance models in flux estimation from urban regions.
Controls on the Distributions of Dissolved Cd, Cu, Zn, and Cu‐Binding Organic Ligands in the East China Sea
Authors: Wong Kuo Hong , Obata Hajime , Ikhsani Idha Yulia , Muhammad Ronald 
Published: June 2021

AbstractThe East China Sea (ECS) is a complex marginal sea with potential sources and sinks of trace metals. In this study, we investigated the distributions of dissolved Cd, Cu, Zn, and Cu‐binding organic ligands in the ECS. Concentrations of Cd and macronutrients were below detection limit in the surface Kuroshio waters. Surface Zn concentrations increased along the Kuroshio Current, which may be attributed to atmospheric deposition. We detected two classes of Cu‐binding organic ligands in those waters, classified as L1 (log K = 13.6–15.2) and L2 (log K = 11.2–13.1), respectively. L1 could be related to biological production while L2 distributions appeared to be controlled by water mass mixing. Particularly, the Kuroshio Surface Water had relatively low L2 concentrations. There were no significant sources of Cu‐binding organic ligands in the intermediate waters. Cd, Cu, and Zn exhibited strong positive relationships with phosphate in the intermediate waters, suggesting that phytoplankton uptake and subsequent regeneration were the dominant controls of these elements at these depths. In deep waters, the distributions of Cd, Cu, and Zn were mainly controlled by water mass mixing. This was apparent from the unique trace metal to macronutrient ratios propagating from the South China Sea and West Philippine Sea to the ECS, according to water mass mixing patterns. Cd/phosphate, Zn/phosphate, Zn/silicate, and Cu/silicate ratios in the ECS were comparable with those in the North Pacific region. This implies the absence of additional supplies of Cd, Cu, Zn, and macronutrients from marginal sources in the ECS.