bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘It's not my story to tell’: ownership and the politics of history in Mocímboa da Praia, Mozambique
Authors: Santos Ana Margarida Sousa 
Published: July 2021

AbstractThe recent history of the northernmost districts of Mozambique has been one of movement and conflict leading people far from their areas of origin and into places where they have to rebuild networks and establish relationships. The Makonde moved from their original area in the Mueda Plateau to neighbouring districts and have to negotiate questions of legitimacy and belonging with the autochthonous population, the Mwani, seen as the ‘owners of the land’ and also the rightful bearers of the histories of the area. Recounting history – owning it – is loaded with references to identity, and weaves in memories and competing experiences of the past. Drawing on literature on history and legitimacy and local understandings of ownership, I discuss the importance of memory and storytelling in the maintenance and reshaping of past events and the different narratives that people create. I investigate how the past is appropriated by different groups and defines belonging by claiming or refusing ownership of local histories.
NORMALIZING URBAN ENTREPRENEURIALISM THROUGH SLY DE‐POLITICIZATION: City Centre Development in Gothenburg and Stockholm
Authors: Hertting Nils , Thörn Catharina , Franzén Mats 
Published: July 2021

AbstractAmong a number of proposals regarding ‘late’ forms of urban neoliberalism, it has recently been argued that urban entreprenurialism has become ‘common sense’ or even ‘dull compulsion’. In this article, we contribute to this discussion by exploring the structural conditions and local strategies for normalizing city‐centre‐oriented urban entrepreneurialism in a Swedish context. In doing so, we return to an important but sometimes overlooked aspect of David Harvey's original concept: the delicate act of organizing urban entrepreneurialism across public and private spheres of the local polity. From this perspective, the act of making urban entrepreneurialism normal is far from ‘dull compulsion’. Drawing on longitudinal case studies of two different public‐private partnerships related to city centre development in the two largest Swedish cities, we highlight the active use of sly, or cunning, de‐politicization strategies among local elite actors. Our analysis leads to the more general claim that we should expect similar sly de‐politicization strategies to be necessary for normalizing urban entrepreneurialism in political contexts characterized by relatively strong local authorities, and in relation to spaces and topics of interest to many and diverse actors.
Using Computed Tomography skeletal surveys to evaluate for occult bony injury in suspected non‐accidental injury cases – A preliminary experience
Authors: Lawson Michael , Tully Joanna , Ditchfield Michael , Kuganesan Ahilan , Badawy Mohamed K 
Published: July 2021

AbstractIntroductionThis case series summarises our institution’s preliminary experience of using computed tomography skeletal surveys (CT‐SS) for the assessment of infants with suspected non‐accidental injury (NAI) who were unable to undergo radiographic skeletal surveys (SS). This paper describes our experience using CT‐SS in terms of radiation doses achieved, occult bony injury detection and forensic utility.MethodsTen infants aged between two weeks and ten months underwent a CT‐SS. The results of the CT‐SS were compared with concurrent imaging results where available. Radiation doses from imaging procedures were calculated for each patient.ResultsSix infants had abnormalities identified on CT‐SS. Two patients had both an ante‐mortem CT‐SS and post‐mortem imaging. All fractures identified on alternate imaging modalities were visible on at least one CT‐SS reconstruction. The radiation dose associated with CT‐SS imaging ranged from 0.73 to 1.46mSv.ConclusionThe radiation dose received by the ten infants in this study was greater than the two skeletal survey approach but was less than the dose received during a bone scintigraphy examination, sometimes used to assess for occult bony injury in this setting. While CT‐SS imaging results could not be compared with those obtained with current contemporaneous gold standard imaging techniques, CT‐SS identified all fractures observed on the radiographic images where performed. CT‐SS also identified additional rib fractures in two patients. Our preliminary findings indicate the need for future prospective studies to clarify the ability of CT‐SS to detect metaphyseal fractures reliably.
Improved genome assembly of Chinese shrimp (Fenneropenaeus chinensis) suggests adaptation to the environment during evolution and domestication
Authors: Wang Qiong , Ren Xianyun , Liu Ping , Li Jitao , Lv Jianjian , Wang Jiajia , Zhang Haien , Wei Wei , Zhou Yuxin , He Yuying , Li Jian 
Published: July 2021

AbstractA high‐quality reference genome is necessary to determine the molecular mechanisms underlying important biological phenomena; therefore, in the present study, a chromosome‐level genome assembly of the Chinese shrimp Fenneropenaeus chinensis was performed. Muscle of a male shrimp was sequenced using PacBio platform, and assembled by Hi‐C technology. The assembled F. chinensis genome was 1.47 Gb with contig N50 of 472.84 Kb, including 57.73% repetitive sequences, and was anchored to 43 pseudochromosomes, with scaffold N50 of 36.87 Mb. In total, 25,026 protein‐coding genes were predicted. The genome size of F. chinensis showed significant contraction in comparison with that of other penaeid species, which is likely related to migration observed in this species. However, the F. chinensis genome included several expanded gene families related to cellular processes and metabolic processes, and the contracted gene families were associated with virus infection process. The findings signify the adaptation of F. chinensis to the selection pressure of migration and cold environment. Furthermore, the selection signature analysis identified genes associated with metabolism, phototransduction, and nervous system in cultured shrimps when compared with wild population, indicating targeted, artificial selection of growth, vision, and behavior during domestication. The construction of the genome of F. chinensis provided valuable information for the further genetic mechanism analysis of important biological processes, and will facilitate the research of genetic changes during evolution.
Clinical characteristics of paraneoplastic neurological syndrome related to different pathological lung cancers
Authors: Ma Jun , Wang Aijun , Jiang Wenjing , Ma Lin , Lin Yan 
Published: July 2021

AbstractBackgroundParaneoplastic syndrome is a distant effect caused by malignant tumors, which is related to the production of cellular immune response. The nervous system is the most common involved system of paraneoplastic syndrome. It is easy to be misdiagnosed. Lung cancer is the most common cancer relating to paraneoplastic neurological syndrome (PNS).MethodThis study retrospectively analyzed clinical data of patients with the combination of PNS and lung cancer between January 2005 and March 2021 at Qilu Hospital of Shandong University, China.ResultsA total of 111 patients were diagnosed with lung cancer complicated with PNS. A total of 95 (85.6%) cases had neurological symptoms as the first symptom. Sixty‐three cases had the pathological results. A total of 43 (68.3%) of small cell lung cancer (SCLC) were diagnosed. PNS patients diagnosed with SCLC included peripheral neuropathy (15 cases, 34.9%). PNS patients diagnosed with non‐small cell lung cancer (NSCLC) included peripheral neuropathy (6 cases, 30%) and limbic encephalitis (6 cases, 30%). Anti‐Hu is popular in patients with SCLC (12 cases, 42.9%) and NSCLC (6 cases, 40%).ConclusionsMost patients with PNS had neurological symptoms as the first symptom. It was more common in males. It had a higher incidence in SCLC. Peripheral neuropathy was the most common PNS associated with SCLC, followed by Lambert‐Eaton syndrome. Peripheral neuropathy and limbic encephalitis were the most common PNS associated with NSCLC. Anti‐Hu is the most common antibodies both in SCLC and NSCLC. Tumor markers do not have significant difference between different pathological types.
High‐volume hemofiltration reduces short‐term mortality with no influence on the incidence of MODS, hospital stay, and hospitalization cost in patients with severe‐acute pancreatitis: A meta‐analysis
Authors: Huang Hongwei , Zhou Qin , Chen Meng‐hua 
Published: July 2021

AbstractThis study aimed to investigate the efficiency, safety and cost‐efficiency of blood purification (BP) in treating patients with severe‐acute pancreatitis (SAP). A literature search was conducted using PubMed, OVID, International Clinical Trials Register (ICTRP), and Cochrane Central Register of Controlled Trials (CENTRAL). A total of 11 prospective studies and 6 retrospective studies, which reported the mortality of 1279 SAP patients, were included for analysis. Decreased short‐term mortality and incidence rate of infection were observed in the high‐volume hemofiltration (HVHF) group, but not in patients treated with other types of BP. There was no significant difference in the incidence of multiple‐organ dysfunction (MODS), duration of hospital stay, or cost of hospitalization between the BP and non‐BP groups. The starting time point, substitution fluid flow rate, filter membrane type, hemofilter change interval, anticoagulation, and sustaining times of BP varied across studies. In conclusion, HVHF may reduce the short‐term mortality (<4 weeks), not long‐term mortality, of SAP patients by decreasing the incidence of infection, while other types of BP did not show a significant beneficial effect. Neither HVHF nor other BP patterns affect the duration of hospital stay, cost of hospitalization, or incidence of MODS in SAP patients.
Populism and foreign policy: The Indonesian case
Authors: Wicaksana I Gede Wahyu , Wardhana Agastya 
Published: July 2021

AbstractWhile the rise and political implications of populism in Southeast Asia have received significant academic attention, the impact of populist ideology on foreign policy remains understudied. This article tries to narrow the gap by presenting a case study of Indonesia under the first tenure of President Joko Widodo (Jokowi), 2014–2019. Drawing on the ideational dimensions of populism, which centers on the anti‐elitist characteristic of populist leaders, it proposes three sets of hypotheses. The main expected elements are: an anti‐elitist stance and a perception of the victimization of the people; a perception about threatening outsiders; and a pro‐people style of communication in the conduct of diplomacy. The empirical findings demonstrate that the substance or objective of Jokowi’s foreign policy does not confirm the anti‐elitist and hostile view of foreigners, although longstanding nationalism remains to dominate Indonesia’s foreign policy. Jokowi’s technocratic populism’s intervention is more effective in introducing and altering the processes and forms of diplomacy, suggesting closer linkages between foreign policy and ordinary citizens.
Sample size estimation for cancer randomized trials in the presence of heterogeneous populations
Authors: Dinart Derek , Bellera Carine , Rondeau Virginie 
Published: July 2021

AbstractA key issue when designing clinical trials is the estimation of the number of subjects required. Assuming for multicenter trials or biomarker‐stratified designs that the effect size between treatment arms is the same among the whole study population might be inappropriate. Limited work is available for properly determining the sample size for such trials. However, we need to account for both, the heterogeneity of the baseline hazards over clusters or strata but also the heterogeneity of the treatment effects, otherwise sample size estimates might be biased. Most existing methods account for either heterogeneous baseline hazards or treatment effects but they dot not allow to simultaneously account for both sources of variations. This article proposes an approach to calculate sample size formula for clustered or stratified survival data relying on frailty models. Both theoretical derivations and simulation results show the proposed approach can guarantee the desired power in worst case scenarios and is often much more efficient than existing approaches. Application to a real clinical trial designs is also illustrated.
BCAS3 exhibits oncogenic properties by promoting CRL4A‐mediated ubiquitination of p53 in breast cancer
Authors: Zhou Zhe , Qiu Rongfang , Liu Wei , Yang Tianshu , Li Gen , Huang Wei , Teng Xu , Yang Yunkai , Yu Hefen , Yang Yang , Wang Yan 
Published: July 2021

AbstractObjectivesBreast cancer‐amplified sequence 3 (BCAS3) was initially found to be amplified in human breast cancer (BRCA); however, there has been little consensus on the functions of BCAS3 in breast tumours.Materials and methodsWe analysed BCAS3 expression in BRCA using bio‐information tools. Affinity purification and mass spectrometry were employed to identify BCAS3‐associated proteins. GST pull‐down and ubiquitination assays were performed to analyse the interaction mechanism between BCAS3/p53 and CUL4A‐RING E3 ubiquitin ligase (CRL4A) complex. BCAS3 was knocked down individually or in combination with p53 in MCF‐7 cells to further explore the biological functions of the BCAS3/p53 axis. The clinical values of BCAS3 for BRCA progression were evaluated via semiquantitative immunohistochemistry (IHC) analysis and Cox regression.ResultsWe reported that the expression level of BCAS3 in BRCA was higher than that in adjacent normal tissues. High BCAS3 expression promoted growth, inhibited apoptosis and conferred chemoresistance in breast cancer cells. Mechanistically, BCAS3 overexpression fostered BRCA cell growth by interacting with the CRL4A complex and promoting ubiquitination and proteasomal degradation of p53. Furthermore, BCAS3 could regulate cell growth, apoptosis and chemoresistance through a p53‐mediated mechanism. Clinically, BCAS3 overexpression was significantly correlated with a malignant phenotype. Moreover, higher expression of BCAS3 correlates with shorter overall survival (OS) in BRCA.ConclusionsThe functional characterization of BCAS3 offers new insights into the oncogenic properties and chemotherapy resistance in breast cancer.
Ethical considerations regarding COVID‐19 vaccination for transplant candidates and recipients
Authors: Parent Brendan , Caplan Arthur , Mehta Sapna A. 
Published: July 2021

AbstractSolid organ transplant (SOT) candidates and recipients were not included in the COVID‐19 vaccine trials that have justified vaccine administration to millions worldwide and will be critical to ending the pandemic. The risks of COVID‐19 for SOT candidates and recipients combined with data about this population's response to other vaccines has led to transplant centers recommending vaccination for their candidates and recipients in accordance with guidance from major transplant organizations. Relevant ethics considerations include: weighing the low risk of vaccination causing transplant complications against potentially limited antibody response of vaccines for transplant recipients; the equitable distribution of vaccines among vulnerable populations; the duty to steward and respect organs as limited resources; the duty to support vaccination; and patient autonomy. Vaccinated transplant patients and candidates should also consider participating in research studies to better understand the efficacy and potential long‐term risks in this patient population. There are difficult scenarios, like timing transplant after second vaccine dose, when to administer the second dose to a partially vaccinated candidate who gets an organ match, whether to vaccinate a recent transplant recipient with low exposure risk and which vaccine to use. Here we provide ethics considerations for vaccinating different groups within the transplant population.
A guideline for the outpatient management of glycaemic control in people with cancer
Authors: Joharatnam‐Hogan Nalinie , Chambers Pinkie , Dhatariya Ketan , Board Ruth ,   the Joint British Diabetes Society for Inpatient Care (JBDS), UK Chemotherapy Board (UKCB)
Published: July 2021

AbstractIndividuals with cancer are at increased risk of developing new‐onset diabetes mellitus and hyperglycaemia, and an estimated 20% of people with cancer already have an underlying diagnosis of diabetes mellitus. People with both cancer and diabetes may have an increased risk of toxicities, hospital admissions and morbidity, with hyperglycaemia potentially attenuating the efficacy of chemotherapy often secondary to dose reductions and early cessation. Numerous studies have demonstrated that hyperglycaemia is prognostic of worse overall survival and risk of cancer recurrence. These guidelines aim to provide the oncology/haemato‐oncology and diabetes multidisciplinary teams with the tools to manage people with diabetes commencing anti‐cancer/glucocorticoid therapy, as well as identifying individuals without a known diagnosis of diabetes who are at risk of developing hyperglycaemia and new‐onset diabetes.
Thermomechanical analysis of riveted carbon fiber laminates for aerospace applications
Authors: Scarselli Gennaro , Carrino Stefano , Nobile Riccardo 
Published: July 2021

AbstractExperimental fatigue tests performed on riveted carbon fiber laminates showed that the specimens, after some thousands of cycles, heated up, reaching around the rivet holes high temperatures. These temperatures if not properly controlled could be detrimental for the joint health. In order to understand the relative importance of all the mechanical and geometric parameters involved in the joint manufacturing, a numerical model of the joined carbon fiber laminates was developed using a commercial finite elements code. A simplified analytical model of heat transfer was then used to simulate the rivets thermal behavior under the assigned operating conditions: this model allowed comparisons with finite elements and can be used for simple thermal simulations. The numerical and analytical results were found in a good agreement with the available experimental results. The present research conclusions can be used for drawing better design rules in the definition of riveted carbon fiber laminates.
Effectiveness of fibreoptic endoscopic evaluation of swallowing and dietary intervention during home‐visit dental care in older individuals
Authors: Tajitsu Megumi , Ishihata Kiyohide , Tezuka Masahiro , Yoshimura Takuya , Ichiki Misaki , Ohta Hiromi , Nohara Kanji , Nakamura Norifumi 
Published: July 2021

BackgroundCurrently, patients with dysphagia are receiving dietary management that deviates from their original swallowing function.ObjectiveTo evaluate the clinical significance of fibreoptic endoscopic evaluation of swallowing (FEES) and dietary intervention (DI) by multi‐professional collaboration during visit care for determining the actual oral intake status in patients with dysphagia.MethodsFive hundred and eighteen patients with dysphagia underwent FEES, focusing on the penetration‐aspiration scale, and DI. Oral intake status was categorised using the functional oral intake scale (FOIS). FOIS scores at the first visit, after FEES, and at the reassessment were compared.ResultsAt the first visit, 34.7% of the patients had an FOIS score of level 1 (no oral intake) and 65.3% had a score of level 2 or higher (capable of oral intake). Following FEES, 7.1% of patients had an FOIS score of level 1, and 44.4% had a score of level 2 with resumption of oral intake. At the reassessment, 489 patients (94.4%) were capable of oral ingestion (FOIS level 2 or higher). There were significant differences between the distributions of FOIS scores at the first visit and following FEES (P < .01) and between those at the first visit and at the reassessment (P < .01). Regarding tube feeding, 17 (5.9%) of 289 patients, who had received tube feeding at the first visit, were completely capable of oral intake following FEES and at the reassessment.ConclusionAppropriate evaluation of swallowing function using FEES and DI helps to understand the definite swallowing function in patients with dysphagia.
Dermatology inpatient consultations in a tertiary hospital – a retrospective analysis
Authors: Joseph Joseph , Truong Kelvin , Smith Annika , Fernandez‐Penas Pablo 
Published: July 2021

AbstractBackgroundDermatology consultation has been shown to have a significant beneficial impact on admitted hospital patients with concurrent or newly diagnosed skin conditions. This study aimed to determine the change in diagnosis and management after dermatology consultation in a tertiary Australian referral hospital.MethodsA retrospective analysis of dermatology consultations for hospital inpatients from June 1, 2018, through November 11, 2019, was performed. Demographic and clinical data were extracted from electronic medical records, and a chi‐squared test was used to analyze categorical variables.ResultsThere were 306 consultations during the period of interest. The male to female ratio was 1:1 with a median age of 63. Consultations were most often requested by medical teams (69%), and the majority of patients seen in the emergency department were discharged home (86%). In 44% of cases, the requesting team did not provide a diagnosis; in the cases where it did provide a diagnosis, it was changed 57.9% of the time. The most commonly misdiagnosed conditions were dermatitis and skin infections. Dermatologists established or changed management in 82% of cases, and a total of 676 suggestions were made for management.ConclusionThe results of this review reinforce the value of dermatology input in the diagnosis and management of hospital in patients. Ensuring maintained presence of hospital‐based dermatologists has the potential to improve diagnosis and management of cutaneous issues early on; by extension, this can minimize unnecessary investigations, improve the quality of healthcare, reduce hospital burden, and facilitate outpatient follow‐up.
Review of chemotherapy‐associated paronychia
Authors: Gupta Mohit K. , Lipner Shari R. 
Published: July 2021

AbstractChemotherapy‐associated paronychia (CAP) is an inflammation of the nail folds in response to various chemotherapeutic medications. Altered proliferation of keratinocytes or nail matrix stem cells is thought to be a major causative factor. Prophylactic tetracyclines, topical povidone‐iodine, and general irritation avoidance measures are among some of the recommended interventions for CAP. Appropriate recognition and treatment of CAP are important for prevention of chemotherapy dose reduction or medication discontinuation.
Effects of bacterial cellulose on glucose metabolism in an in vitro chyme model and its rheological evaluation
Authors: Zhang Le‐Le , Zhang Wen , Peng Fa‐Bo , Chen He , Shu Guo‐Wei 
Published: July 2021

AbstractHyperglycaemia affects the health of people worldwide. The study investigated the effects of bacterial cellulose (BC) on glucose metabolism using an in vitro chyme model, including glucose adsorption, glucose diffusion, kinetics model of glucose and rheological properties of BC. The results indicated that BC exhibited significant inhibition of α‐amylase in a dose‐dependent manner (IC50 = 7.86 mg mL−1) and could significantly adsorb glucose by binding to the glucose molecules (4.11 ± 0.18 mmol g−1) (P < 0.05). The BC chyme system was a non‐Newtonian fluid showing shear thinning and has the characteristics of elastic solid. The diffusion behaviour of glucose in the BC chyme system conformed to first‐order release kinetics model, indicating its inhibition of glucose diffusion by changing the rheological properties of chyme. This study provides a theoretical basis for dietary intervention and nutritional support for patients with hyperglycaemia.