bluuebunny/crossref_metadata_2025_split huggingface dataset:
An experimental study on seismic performance levels of highly corroded reinforced concrete columns
Authors: Celik Alper , Yalciner Hakan , Kumbasaroglu Atila , Turan Ahmet İhsan 
Published: July 2021

AbstractIn the literature, only one empirical model is available as a nondestructive method for the prediction of seismic performance levels of corroded reinforced concrete (RC) columns as a function of the initial corrosion crack width at lower corrosion levels. Because of the ruptured transverse reinforcement bars at higher corrosion levels, the structural behavior may turn brittle in terms of shear failure. Therefore, in this study, higher corrosion levels for a different concrete strength level from that empirical model were studied. To do this, four RC columns were subjected to accelerated corrosion, and the widths of initial corrosion cracks were measured. The corroded RC columns were then tested under combined constant axial load and cyclic lateral displacement excursions. After the cyclic loading test, the actual corrosion levels at each reinforcement bar were obtained by extracting the reinforcement bars from the concrete. Test results showed that the prediction of seismic performance levels of corroded RC columns based on initial corrosion crack widths were limited owing to the nonlinear increase in the crack width with the increase in the corrosion levels. New empirical models were developed to predict the remaining energy capacities and seismic performance levels of the corroded RC columns.
Whose Kids Did You Eat? Genetic Identification of Species and Parents of Larval Lampreys in Fish Predator Guts
Authors: Arakawa Hiroaki , Lampman Ralph T. , Hess Jon E. 
Published: July 2021

AbstractThe Pacific Lamprey Entosphenus tridentatus is an important species both ecologically and culturally, but their population numbers and range have declined severely in the past several decades in the Columbia Basin. In freshwater ecosystems, larval lampreys are candidate prey species for many fish predators, but little is known regarding the magnitude of predation they currently experience. Predation on larval Pacific Lampreys may be substantially underestimated by morphological gut content analysis because their soft bodies are quickly digested and leave no hard evidence, such as bones and scales. We conducted an experimental predation study and analyzed larval Pacific Lampreys in the gut contents of predators’ digestive tracts via both morphological and molecular methods. Whereas most consumed larval lampreys (67–100%) were morphologically unidentifiable within two nights, genetic species identification rates using four single nucleotide polymorphisms from stomachs were high (83%). The single nucleotide polymorphisms optimized for parentage in Pacific Lamprey also successfully identified the parents of four out of five Pacific Lampreys with complete genotypes. When a genetic baseline of candidate parents is available, this molecular technique using parentage‐based tagging offers a novel method for determining precise characteristics of predation behavior in field studies, including the ages and natal origins of larvae being consumed.
Lipid coating technology: A potential solution to address the problem of sticky containers and vanishing drugs
Authors: Ma Gamaliel Junren , Yoon Bo Kyeong , Sut Tun Naw , Yoo Ki Yeol , Lee Seung Hwa , Jeon Won‐Yong , Jackman Joshua A. , Ariga Katsuhiko , Cho Nam‐Joon 
Published: July 2021

AbstractPharmaceutical drugs and vaccines require the use of material containers for protection, storage, and transportation. Glass and plastic materials are widely used for packaging, and a longstanding challenge in the field is the nonspecific adsorption of pharmaceutical drugs to container walls – the so‐called “sticky containers, vanishing drugs” problem – that effectively reduces the active drug concentration and can cause drug denaturation. This challenge has been frequently discussed in the case of the anticancer drug, paclitaxel, and the ongoing coronavirus disease 2019 (COVID‐19) pandemic has brought renewed attention to this material science challenge in light of the need to scale up COVID‐19 vaccine production and to secure sufficient quantities of packaging containers. To reduce nonspecific adsorption on inner container walls, various strategies based on siliconization and thin polymer films have been explored, while it would be advantageous to develop mass‐manufacturable, natural material solutions, especially ones involving pharmaceutical grade excipients. Inspired by how lipid nanoparticles have revolutionized the vaccine field, in this perspective, we discuss the prospects for developing lipid bilayer coatings to prevent nonspecific adsorption of pharmaceutical drugs and vaccines and how recent advances in lipid bilayer coating fabrication technologies are poised to accelerate progress in the field. We critically discuss recent examples of how lipid bilayer coatings can prevent nonspecific sticking of proteins and vaccines to relevant material surfaces and examine future translational prospects.
The Single Digital Gateway Regulation as an Enabler and Constraint of Once-Only in Europe
Authors: Graux Hans 
Published: July 2021

AbstractThe adoption of the Single Digital Gateway Regulation is a gamechanger in European e-government. For the first time, it creates a horizontal, non-sector specific legal framework for the direct exchange of digital evidence between public administrations in different Member States. However, these exchanges require public administrations to have a certain degree of trust in each other, which is built on a shared legal basis. The Single Digital Gateway Regulation achieves its goal of creating a legal basis and establishing trust, but also builds in a number of explicit and implicit legal constraints. These will help make the once-only principle in Europe a reality, but also enshrine limitations that will require revisions and expansions of the Regulation at some point in the future. This paper examines the genesis of the Regulation, its legal choices and priorities, the resulting implications and limitations, and potential challenges for the future.
PI-RADS 2.1 und strukturierte Befundung der Magnetresonanztomographie der Prostata
Authors: Hötker Andreas , Donati Olivio F. 
Published: July 2021

Zusammenfassung
Klinisches/methodisches Problem
Die Identifikation klinisch signifikanter Prostatakarzinome bei gleichzeitigem Vermeiden einer Überdiagnostik niedrigmaligner Tumoren stellt eine Herausforderung in der klinischen Routine dar.

Radiologische Standardverfahren
Die gemäß PI-RADS-Richtlinien (Prostate Imaging Reporting and Data System Guidelines) akquirierte und interpretierte multiparametrische Magnetresonanztomographie (MRT) der Prostata ist als klinischer Standard bei Urologen und Radiologen akzeptiert.

Methodische Innovationen
Die PI-RADS-Richtlinien sind neu auf Version 2.1 aktualisiert worden und beinhalten neben präzisierten technischen Anforderungen einzelne Änderungen in der Läsionsbewertung.

Leistungsfähigkeit
Die PI-RADS-Richtlinien haben entscheidende Bedeutung in der Standardisierung der multiparametrischen MRT der Prostata erlangt und bieten Vorlagen zur strukturierten Befundung, was die Kommunikation mit dem Zuweiser erleichtert.

Bewertung
Die nun auf Version 2.1 aktualisierten Richtlinien stellen eine Verfeinerung der verbreiteten Version 2.0 dar. Dabei wurden viele Aspekte der Befundung präzisiert, einige vorbekannte Limitationen bleiben jedoch bestehen und erfordern die weitere Verbesserung der Richtlinien in kommenden Versionen.
Leitlinientreue und Qualitätssicherung in der bildgebenden Diagnostik bei Verdacht auf Kindesmisshandlung in Deutschland
Authors: Dargel Susanne , Stenzel Martin , Stöver Brigitte , Schleußner Ekkehard , Wittschieber Daniel , Banaschak Sibylle , Mentzel Hans-Joachim 
Published: July 2021

Zusammenfassung
Hintergrund
Die bildgebende Diagnostik nimmt in der Evaluation nichtakzidentieller Verletzungsfolgen im Kindesalter eine Schlüsselrolle ein. Frakturen sind nach Hautläsionen wie Abschürfungen oder Hämatomen die zweithäufigste Folge körperlicher Kindesmisshandlung. Mit Hilfe radiologischer Kriterien können nichtakzidentielle von akzidentiellen Frakturen differenziert werden. Spezielle Frakturtypen wie die klassische metaphysäre Läsion können nur bei hoher Bildqualität differenziert werden.

Fragestellung
In einer prospektiven Analyse sollten Leitlinientreue und Qualitätssicherung der radiologischen Diagnostik bei Misshandlungsverdacht in Deutschland erfasst werden. Dazu wurden Quantität und diagnostische Qualität in der universitären und nichtuniversitären Versorgung sowie in Abhängigkeit einer vorhandenen kinderradiologischen Fachabteilung analysiert.

Material und Methoden
Es wurden 958 Röntgenuntersuchungen von 114 vermuteten Misshandlungsfällen (46 Mädchen, 68 Jungen) bewertet. Insgesamt 42 Fälle aus universitären, 42 aus maximalversorgenden und 30 aus regelversorgenden Kliniken mit einem medianen Alter von 6 Monaten (3 Wochen – 3. Lebensjahr) wurden als DICOM-Daten von 3 Kinderradiologen im Konsensverfahren hinsichtlich Leitlinientreue und verschiedener Qualitätsparameter beurteilt. Ein Begleitfragebogen sollte die theoretischen Kenntnisse mit der jeweiligen praktischen Umsetzung vergleichen.

Ergebnisse
Je Fall wurden im Mittel 8,4 Röntgenaufnahmen (1–22) angefertigt. In 12 von 114 beurteilten Fällen (10 %) lag ein vollständiger Skelettstatus nach S1-Leitlinie GPR vor. In 13 Fällen (10,5 %) wurde ein Babygramm durchgeführt. Abteilungen mit kinderradiologischem Schwerpunkt fertigten signifikant mehr Röntgenaufnahmen je Skelettstatus an als Einrichtungen ohne Schwerpunkt (p < 0,05). Eine signifikant höhere qualitative Umsetzung wurde in Universitätskliniken verzeichnet (p < 0,001). Eine Übereinstimmung von Fragebogenantwort und vorliegendem Bildmaterial zeigte sich unabhängig der Institutionsart nur marginal.

Diskussion
In Deutschland fehlt bislang mehrheitlich ein leitliniengerechtes Vorgehen bei Misshandlungsverdacht. Es bleibt abzuwarten, ob sich dies mit der breiteren Implementierung von Kinderschutzgruppen und der 2019 verabschiedeten S3-Kinderschutzleitlinie (AWMF-Registrierungsnummer: 027-069) zukünftig ändern wird. Die Etablierung von Referenzzentren für Zweitbefundung und Empfehlungen zur Aufnahmetechnik können zusätzlich die Versorgungsqualität nachhaltig verbessern.
High compliance with the injury prevention exercise programme Knee Control is associated with a greater injury preventive effect in male, but not in female, youth floorball players
Authors: Åkerlund Ida , Waldén Markus , Sonesson Sofi , Lindblom Hanna , Hägglund Martin 
Published: July 2021

Abstract
Purpose
Evaluate team and player compliance with the Knee Control injury prevention exercise programme, study the association between player compliance and injury rates, and compare coach demographics, baseline prevention expectancies, and programme utilisation between teams with high and low compliance.

Methods
Prospective one-season cohort study based on a cluster randomised controlled trial on 301 (107 female) floorball players aged 12–17 years. Floorball exposure and injuries were self-reported weekly by players using the Oslo Sports Trauma Research Center questionnaire. Team and player compliance to Knee Control was reported monthly by coaches. Additionally, coaches answered pre- and post-season surveys. Teams were divided into a high (≥ 80%) or low (< 80%) compliance group based on their use of Knee Control during the season. Players were divided into three compliance groups based on their average weekly number of Knee Control sessions; high (≥ 2 sessions), intermediate (≥ 1 to < 2 sessions), and low dose (< 1 session).

Results
Mean team compliance for the high and low compliance groups were 95% (range 82–100) and 50% (range 13–66), respectively. Mean ± SD weekly Knee Control dose in the three player compliance groups were 2.4 ± 0.3, 1.4 ± 0.3, and 0.7 ± 0.3 sessions, respectively. There were no differences in total injury incidence between the player compliance groups, but players in the high-dose group had a 35% lower prevalence of injuries overall [adjusted prevalence rate ratio (PRR) 0.65, 95% CI 0.48–0.89] and 60% lower prevalence of substantial injuries (adjusted PRR 0.40, 95% CI 0.26–0.61) compared with the low-dose group. Male players in the high-dose group had consistently lower injury incidence and prevalence, while no between compliance group differences were seen in female players. There were no differences in sex, years of coaching experience, or baseline prevention expectancies in general between coaches for teams in the high vs. low compliance groups, but teams in the high compliance group had a better utilisation fidelity.

Conclusion
There was a clear dose–response relationship between more frequent Knee Control use and lower injury rates in male floorball players, but not in female players. Teams with higher compliance also showed a better utilisation fidelity with the programme.

Level of evidence
Level II.
Galileo precise orbit determination with optical two-way links (OTWL): a continuous wave laser ranging and time transfer concept
Authors: Marz Stefan , Schlicht Anja , Hugentobler Urs 
Published: July 2021

AbstractIn this simulation study we analyze the benefit of ground-space optical two-way links (OTWL) for Galileo precise orbit determination (POD). OTWL is a concept based on continuous wave laser ranging and time transfer with modulated signals from and to ground stations. The measurements are in addition to Global Navigation Satellite System (GNSS) observations. We simulate the measurements with regard to 16 Galileo Sensor Stations. In the simulation study we assume that the whole Galileo satellite constellation is equipped with terminals for OTWL. Using OTWL together with Galileo L-band, in comparison with an orbit solution calculated with L-band-only, demonstrates the advantage of combining two ranging techniques with different influences of systematic errors. The two-way link allows a station and satellite clock synchronization. Furthermore, we compare the ground-space concept with the satellite-to-satellite counterpart known as optical two-way inter-satellite links (OISL). The advantage of OTWL is the connection between the satellite system and the solid Earth as well as the possibility to synchronize the satellite clocks and the ground station clocks. The full network, using all three observation types in combination is simulated as well. The possibility to estimate additional solar radiation pressure (SRP) parameters within these combinations is a clear benefit of these additional links. We paid great attention to simulate systematic effects of all observation techniques as realistically as possible. For L-band these are measurement noise, tropospheric delays, phase center variation of receiver and transmitter antennas, constant and variable biases as well as multipath. For optical links we simulated colored and distance-dependent noise, offsets due to the link repeatability and offsets related to the equipment calibration quality. In addition, we added a troposphere error for the OTWL measurements. We discuss the influence on the formal orbit uncertainties and the effects of the systematic errors. Restrictions due to weather conditions are addressed as well. OTWL is synergetic with the other measurement techniques like OISL and can be used for data transfer and communication, respectively.
Isolation of bacteria from artificial bronchoalveolar lavage fluid using density gradient centrifugation and their accessibility by Raman spectroscopy
Authors: Wichmann Christina , Rösch Petra , Popp Jürgen 
Published: July 2021

AbstractRaman spectroscopy is an analytical method to identify medical samples of bacteria. Because Raman spectroscopy detects the biochemical properties of a cell, there are many factors that can influence and modify the Raman spectra of bacteria. One possible influence is a proper method for isolation of the bacteria. Medical samples in particular never occur in purified form, so a Raman-compatible isolation method is needed which does not affect the bacteria and thus the resulting spectra. In this study, we present a Raman-compatible method for isolation of bacteria from bronchoalveolar lavage (BAL) fluid using density gradient centrifugation. In addition to measuring the bacteria from a patient sample, the yield and the spectral influence of the isolation on the bacteria were investigated. Bacteria isolated from BAL fluid show additional peaks in comparison to pure culture bacteria, which can be attributed to components in the BAL sample. The isolation gradient itself has no effect on the spectra, and with a yield of 63% and 78%, the method is suitable for isolation of low concentrations of bacteria from a complex matrix.
General Relativity and the AKSZ Construction
Authors: Canepa G. , Cattaneo A. S. , Schiavina M. 
Published: July 2021

AbstractIn this note the AKSZ construction is applied to the BFV description of the reduced phase space of the Einstein–Hilbert and of the Palatini–Cartan theories in every space-time dimension greater than two. In the former case one obtains a BV theory for the first-order formulation of Einstein–Hilbert theory, in the latter a BV theory for Palatini–Cartan theory with a partial implementation of the torsion-free condition already on the space of fields. All theories described here are BV versions of the same classical system on cylinders. The AKSZ implementations we present have the advantage of yielding a compatible BV–BFV description, which is the required starting point for a quantization in presence of a boundary.
In Vitro Antidiabetic, Antioxidant Activity, and Probiotic Activities of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei Strains
Authors: Won GaYeong , Choi Soo-Im , Park NaYeong , Kim Ji-Eun , Kang Chang-Ho , Kim Gun-Hee 
Published: July 2021

AbstractDiabetes, a chronic metabolic disorder, is characterized by persistent hyperglycemia. This study aimed to evaluate the hypoglycemic and antioxidant activities of lactic acid bacteria strains isolated from humans and food products and investigate the probiotic properties of the selected four strains. The hypoglycemic activity of the isolated strains was examined by evaluating the α-glucosidase and α-amylase inhibitory activities. The antioxidant activity was measured using the DPPH, ABTS, and FRAP assays. Four strains (Lactiplantibacillus plantarumMG4229, MG4296, MG5025, andLacticaseibacillus paracaseiMG5012) exhibited potent α-glucosidase inhibitory (>75%) and α-amylase inhibitory (>85%) activities, which were comparable to those of acarbose (>50%; 1000 μg/mL). Similarly, the radical scavenging and antioxidant activities of the four strains were comparable to those of ascorbic acid (50 μg/mL). Additionally, the probiotic properties of the four selected strains were examined based on acid and bile salt tolerance, auto-aggregation ability, and antibiotic resistance. The four strains were resistant to pH 2 (>50% of survivability) and 0.5% bile salt (>80% of survivability). Therefore, we suggest that the selected strains with hypoglycemic, antioxidant, probiotic properties can potentially prevent diabetes.
Clinical presentation and management of childhood intussusception in South Africa
Authors: Cox Sharon , Withers Aletha , Arnold Marion , Chitnis Milind , de Vos Corné , Kirsten Mari , le Grange Susanna M. , Loveland Jerome , Machaea Sello , Maharaj Ashwini , Madhi Shabir A. , Tate Jacqueline E. , Parashar Umesh D. , Groome Michelle J. 
Published: July 2021

Abstract
Purpose
We assessed management and outcomes for intussusception at nine academic hospitals in South Africa.

Methods
Patients ≤ 3 years presenting with intussusception between September 2013 and December 2017 were prospectively enrolled at all sites. Additionally, patients presenting between July 2012 and August 2013 were retrospectively enrolled at one site. Demographics, clinical information, diagnostic modality, reduction methods, surgical intervention and outcomes were reviewed.

Results
Four hundred seventy-six patients were enrolled, [54% males, median age 6.5 months (IQR 2.6–32.6)]. Vomiting (92%), bloody stool (91%), abdominal mass (57%), fever (32%) and a rectal mass (29%) represented advanced disease: median symptom duration was 3 days (IQR 1–4).
Initial reduction attempts included pneumatic reduction (66%) and upfront surgery (32%). The overall non-surgical reduction rate was 28% and enema perforation rate was 4%. Surgery occurred in 334 (70%), 68 (20%) patients had perforated bowel, bowel resection was required in 61%.
Complications included recurrence (2%) and nosocomial sepsis (4%). Length of stay (LOS) was significantly longer in patients who developed complications. Six patients died—a mortality rate of 1%. There was a significant difference in reduction rates, upfront surgery, bowel resection, LOS and mortality between centres with shorter symptom duration compared longer symptom duration.

Conclusion
Delayed presentation was common and associated with low success for enema reduction, higher operative rates, higher rates of bowel resection and increased LOS. Improved primary health-care worker education and streamlining referral pathways might facilitate timely management.
A metal-free salalen ligand with anti-tumor and synergistic activity in resistant leukemia and solid tumor cells via mitochondrial pathway
Authors: Hopff Sina M. , Wang Qifang , Frias Corazon , Ahrweiler Marie , Wilke Nicola , Wilke Nathalie , Berkessel Albrecht , Prokop Aram 
Published: July 2021

Abstract
Purpose
Since the discovery of the well-known cis-platin, transition metal complexes are highly recognized as cytostatic agents. However, toxic side effects of the metal ions present in the complexes may pose significant problems for their future development. Therefore, we investigated the metal-free salalen ligand WQF 044.

Methods
DNA fragmentations in leukemia (Nalm6) and solid tumor cells (BJAB, MelHO, MCF-7, RM82) proved the apoptotic effects of WQF 044, its overcoming of resistances and the cellular pathways that are affected by the substance. The apoptotic mechanisms finding were supported by western blot analysis, measurement of the mitochondrial membrane potential and polymerase chain reactions.

Results
A complex intervention in the mitochondrial pathway of apoptosis with a Bcl-2 and caspase dependence was observed. Additionally, a wide range of tumors were affected by the ligand in a low micromolar range in-vitro. The compound overcame multidrug resistances in P-gp over-expressed acute lymphoblastic leukemia and CD95-downregulated Ewing’s sarcoma cells. Quite remarkable synergistic effects with vincristine were observed in Burkitt-like lymphoma cells.

Conclusion
The investigation of a metal-free salalen ligand as a potential anti-cancer drug revealed in promising results for a future clinical use.