bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of immune checkpoint inhibitors for EGFR mutated non-small cell lung cancer: a network meta-analysis
Authors: Zhu Lin , He Wenjuan , Xie Cunlei , Shu Yang , Zhang Chunxia , Zhu Yawen 
Published: December 2024

IntroductionNon-small cell lung cancer (NSCLC) constitutes approximately 80–85% of cancer-related fatalities globally, and direct and indirect comparisons of various therapies for NSCLC are lacking. In this study, we aimed to compare the efficacy and safety of immune checkpoint inhibitors (ICIs) in patients with epidermal growth factor receptor (EGFR)-mutated NSCLC.MethodsThe electronic databases were systematically searched from inception until March 18, 2024. Studies comparing two or more treatments involving ICIs in patients with EGFR-mutated NSCLC were included. The primary endpoints were overall survival (OS) and progression-free survival (PFS), and the secondary endpoints were overall response rate (ORR), any grade adverse events (AEs), grade ≥3 AEs, and AEs requiring treatment discontinuation. The R software with the gemtc package was used to compare the outcomes of the different treatments.ResultsIn 11 eligible studies involving 1462 patients and 5 regimens (chemotherapy [chemo], ICI, ICI+chemo, antiangiogenesis+chemo, and ICI+antiangiogenesis+chemo), ICI+antiangiogenesis+chemo achieved the most favorable OS compared to chemo (HR=0.74, 95% CI 0.41–1.23), ICI+chemo (HR=0.94, 95% CI 0.57–1.46), and ICI (HR=0.58, 95% CI 0.27–1.08) and a nearly equivalent effect to antiangiogenesis+chemo (HR=1.01, 95% CI 0.52–1.92). The PFS and ORR results were similar to those of OS. ICI monotherapy exhibited the lowest toxicity profile.ConclusionsThese findings indicate that ICI+antiangiogenesis+chemo may be potentially beneficial for patients with EGFR-mutated NSCLC. However, the observed difference was not significant; thus, more studies are needed to confirm the efficacy and safety of the combined ICI treatment strategy.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023424781.
Perspectives of old-age and dementia researchers on communication with policymakers and public research funding decision-makers: an international cross-sectional survey
Authors: Fusdahl Peter , Borda Miguel Germán , Baldera Jonathan Patricio , Aarsland Dag , Khachaturian Ara , Braut Geir Sverre 
Published: December 2024

IntroductionSociety commonly believes that research knowledge is complementary to public decision-making. This study aimed to understand the perspectives and implications of dementia researchers communicating with policymakers and public research decision-makers (public officials).MethodsThis study uses 24 questions from an anonymous, online survey, which was received by 392 members of nine European, Latin American, and United States medical researcher associations/networks in the fields of age-related neurological degeneration and dementia medicine. The data were analyzed via crosstab analysis, two group comparison analyses, and a logistic regression model.ResultsIn total, 91 (23.2%) respondents completed the questionnaire. Eight independent variables were related to researchers’ research discipline, research remuneration, experience, authorship, H-index, and research grants. The statistically significant variables determining whether the respondents had contact with public officials were “Years of research experience” (p = 0.004), “Number of articles first-authored in the last 5 years” (p = 0.007), and “Average H-index in the last 5 years” (p = 0.048) [median (IQR)]; 47% of the surveyed researchers had been in contact with public officials in the last 12 months. The most frequently communicated topics were the importance of their own research to society (61%) and their own funding (60%); 87% (n = 79) of the researchers did not believe that public officials had a very good understanding of their dementia research.ConclusionLess than half (47%) of dementia researchers communicate with public officials, and they communicate mostly about the importance of their own research and funding their own research. Nine of 10 researchers do not believe that public officials understand their research well.
Disease burden and trends of lung cancer attributable to nickel among Chinese and global population: a cross-sectional study
Authors: Lu Huaye , Han Lei , Wu Peihong , Liu Xin , Jiang Qingtao 
Published: December 2024

BackgroundNickel is a well-established carcinogen, and China stands as a significant producer of nickel compounds. Nickel-associated lung cancer is increasingly acknowledged as a pressing public health concern. This study presents a comprehensive analysis at temporal, spatial, and population levels utilizing the most recent data from GBD 2019 to estimate the disease burden of nickel-associated lung cancer from 1990 to 2019, and make predictions to 2035.MethodsWe delineated data on nickel-associated lung cancer concerning mortality, disability-adjusted life years (DALY), and age-standardized rates (ASRs) over a 30-year period based on the global burden of disease (GBD) 2019. Joinpoint regression analysis was utilized to identify temporal changes and to estimate the annual percentage change (APC) as well as the average annual percentage change (AAPC) for each trend segment. The Nordpred model was employed to elaborate on ASRs trends from 1990 to 2019, along with projections for the subsequent 15 years.ResultsIn both China and globally, the mortality rate from nickel-associated lung cancer and the associated DALYs have increased by 145.8, 77.8, 120.2, and 64.6%, respectively. ASRs within Chinese and global populations exhibit a pattern characterized by an initial increase followed by a decrease as age progresses, with males higher than females. The trend for DALY indicates an initial rise followed by a decline, peaking in the year 2027.ConclusionThe age structure of nickel-associated lung cancer patients shows an aging trend, and the ASDR in the Chinese population indicates a potential upward trend when projecting the disease burden of nickel-associated lung cancer over the next 15 years. We should place greater emphasis on the implementation of preventive strategies and the enhancement of the quality of life for current sufferers.
Deciphering dengue: novel RNA barcoding segments for enhanced serotype-specific identification and global surveillance of dengue viruses
Authors: Jiang Shuai , Zhao Gaili , Ding Yunyun , Ye Shunxing , Li Zeqi , You Changqiao , Yin Yan , Guo Xinhong 
Published: December 2024

IntroductionDengue viruses (DENVs), the causative agents of dengue hemorrhagic fever and dengue shock syndrome, undergo genetic mutations that result in new strains and lead to ongoing global re-infections.ObjectivesTo address the growing complexity of identifying and tracking biological samples, this study screened RNA barcode segments for the four DENV serotypes, ensuring high specificity and recall rates for DENV identification using segments.ResultsThrough analyzing complete genome sequences of DENVs, we screened eight barcode segments for DENV, DENV-1, DENV-2, DENV-3, and DENV-4 identification. Comparing the screened barcode segments to sequences of known strains and determining the proportion of correctly or incorrectly identified nucleotides, these segments demonstrated an average recall rate at nucleotide level of 91.34% for four DENV serotypes, a specificity of 99.50% at species level within the Flaviviridae family, and a precision rate of 100% for identifying DENVs. For arboviruses, the nucleotide-level specificity was 63.58%. We designed and used the “Barcoding” software to streamline segment design, integrating automated sequence preprocessing, evaluation of barcode segments, and primer design, significantly reducing manual intervention and enhancing overall efficiency. We also established an online database called “Barcodes” for storing and preparing barcode segments.ConclusionThis work established a standard framework for DENV identification and barcode segment selection, promising significant advancements in the real-time management and control of DENVs, thereby enhancing surveillance capabilities and facilitating targeted interventions in dengue outbreak-prone regions.
Clinical review and drug sensitivity test of Corynebacterium kroppenstedtii complex isolates in non-lactating patients with severe mastitis
Authors: Liang Zuxin , Zeng Zhujun , Liao Yanqiang , Cao Yaxin , Li Dongmei , Deng Ningbo , Lei Yeyan , Long Xuanhui , Shen Chenguang , Xu Rui 
Published: December 2024

BackgroundPrevious microbiological investigations have demonstrated a significant correlation between Corynebacterium kroppenstedtii complex (CKC) infection and mastitis. Recent studies have confirmed the existence of the CKC, with Corynebacterium parakroppenstedtii (C. parakroppenstedtii) identified as the primary infectious agent. Examining the incidence of CKC in cases of severe non-lactational mastitis, alongside the clinical characteristics of infected patients, as well as evaluating the drug sensitivity testing protocols for CKC, can provide a more robust foundation for the diagnosis and treatment of CKC infections.MethodsData regarding the diagnosis and treatment of non-nursing patients with severe mastitis who underwent surgical intervention were extracted from the hospital’s electronic medical record system. Additionally, drug susceptibility tests were conducted on 15 strains of CKC isolated from mammary abscesses as well as DSM 44385 model strains. The effects of β-NAD and Tween80 (TW80) on the antibiotic susceptibility test by AGAR dilution and micro broth dilution were analyzed.ResultsIn this study, C. parakroppenstedtii accounted for 80% (12/15) of the isolates, while Corynebacterium pseudokroppenstedtii made up 13.3% (2/15), and Corynebacterium kroppenstedtii was identified in only 6.7% (1/15) of the cases. There were significant differences in age at first delivery (p &lt; 0.001), prolactin (p &lt; 0.001), CRP (p &lt; 0.05), WBC (p &lt; 0.05), and NEUT (p &lt; 0.05) between CKC positive group and CKC negative group. In the AGAR dilution test, the addition of β-NAD only caused acceptable differences in penicillin G and ciprofloxacin but did not affect 12 antibiotics. There are 14 drugs with good coincidence rates (92.9%) in the micro broth dilution method and agar dilution method without the addition of β-NAD. The addition of 0.05% (v/v) TW80 resulted in all strains being resistant to penicillin G. Daptomycin is not suitable for the micro broth dilution method.ConclusionElderly primiparas with high prolactin levels have a higher risk of CKC infection. The micro broth dilution method is not applicable for EUCAST drug susceptibility testing for CKC and there is no suitable drug susceptibility evaluation procedure for daptomycin against CKC.
EEG-powered cerebral transformer for athletic performance
Authors: Sun Qikai 
Published: December 2024

IntroductionIn recent years, with advancements in wearable devices and biosignal analysis technologies, sports performance analysis has become an increasingly popular research field, particularly due to the growing demand for real-time monitoring of athletes' conditions in sports training and competitive events. Traditional methods of sports performance analysis typically rely on video data or sensor data for motion recognition. However, unimodal data often fails to fully capture the neural state of athletes, leading to limitations in accuracy and real-time performance when dealing with complex movement patterns. Moreover, these methods struggle with multimodal data fusion, making it difficult to fully leverage the deep information from electroencephalogram (EEG) signals.MethodsTo address these challenges, this paper proposes a "Cerebral Transformer" model based on EEG signals and video data. By employing an adaptive attention mechanism and cross-modal fusion, the model effectively combines EEG signals and video streams to achieve precise recognition and analysis of athletes' movements. The model's effectiveness was validated through experiments on four datasets: SEED, DEAP, eSports Sensors, and MODA. The results show that the proposed model outperforms existing mainstream methods in terms of accuracy, recall, and F1 score, while also demonstrating high computational efficiency.Results and discussionThe significance of this study lies in providing a more comprehensive and efficient solution for sports performance analysis. Through cross-modal data fusion, it not only improves the accuracy of complex movement recognition but also provides technical support for monitoring athletes' neural states, offering important applications in sports training and medical rehabilitation.
Exploring the relationship between total serum calcium and melanoma development: a cross-sectional study
Authors: Zhou Qiaochu , Wang Wei , Wang Jinhui , Li Changchang , Ji Jianle 
Published: December 2024

BackgroundMelanoma is the fourth leading cause of cancer-related death worldwide. The continuous exploration and reporting of risk factors of melanoma is important for standardizing and reducing the incidence of the disease. Calcium signaling is a promising therapeutic target for melanoma; however, the relationship between total serum calcium levels and melanoma development remains unclear.MethodsIn this study, we included patients with melanoma from the National Health and Nutrition Examination Survey (NHANES) database from 2003 to 2006 and from 2009 to 2016. The baseline clinical characteristics of the participants were analyzed using the chi-square and rank-sum tests. Subsequently, a fitted model was constructed to evaluate the relationship between total serum calcium levels and melanoma development. The performance of total serum calcium levels and covariates in predicting the risk of melanoma was assessed based on ROC curves. Finally, LASSO regression analysis was performed using the “glmnet” R package to identify clinical characteristics associated with melanoma.ResultsA total of 13,432 participants were included in this study. Age, race, household poverty-to-income ratio, response of the skin to sunlight after a certain period of non-exposure, wearing long-sleeved shirts, frequency of sunscreen use, and arthritis were significantly correlated with the development of melanoma. The p-values of total serum calcium levels in three fitted models were &lt; 0.05, and the OR values were &lt; 1. According to the ROC curves, the AUC values of models 2 and 3 were 0.728 and 0.766, respectively, indicating that the combination of total serum calcium levels and covariates showed better performance in predicting the occurrence of melanoma. Furthermore, LASSO regression analysis revealed seven clinical characteristics significantly associated with melanoma.ConclusionThis study revealed a relationship between total serum calcium levels and melanoma development. Total serum calcium levels combined with phenotypic and clinical characteristics were found to be more effective in predicting the occurrence of melanoma. Therefore, the relationship between total serum calcium levels and melanoma development warrants further investigation in prospective cohort studies.
Dietary diversity and associated factors among children aged 6–23 months attending a public health hospital in Awi zone, Ethiopia, 2023
Authors: Mulatu Sileshi , Ejigu Lemessa Jira , Dinku Habtamu , Tadesse Fikir , Gedif Azeb , Salah Fekiahmed , Workie Hailemariam Mekonnen 
Published: December 2024

BackgroundInadequate dietary diversity among children aged 6–23 months remains a public problem in Ethiopia. Adequate dietary diversity is crucial for children to meet their nutritional demands and promote healthy growth and development in infancy and young childhood.ObjectiveThe study aimed to assess dietary diversity and associated factors among children aged 6–23 months in Awi Zone, Ethiopia, 2023.MethodsThe study was conducted among children aged 6–23 months in Awi Zone, Amhara, Ethiopia, from August to September 2023. A community-based cross-sectional study design was conducted. A simple random sampling approach followed by face-to-face interview data collection techniques was used. To ascertain minimum dietary diversity, a 24 h food recall method comprising eight food item questionnaires was used. A statistical association was found between dependent and independent variables using the adjusted odds ratio with 95% confidence intervals and a p-value of ≤0.05.ResultThis study found that only 192 (47.6%) children aged 6–23-month old had adequate dietary diversity. In this study, variables such as maternal education [AOR 2.36, 95% CI (1.297, 3.957)], birth interval [AOR 2.85, 95% CI (1.45, 4.25)], and food insecurity [AOR = 2.23, 95% CI (1.626, 3.1)] were strongly significant variables for the minimum dietary diversity of the child.Conclusion and recommendationsThe proportion of the minimum dietary diversity was relatively low. Mother’s educational status, low birth intervals, and food insecurity were significant predictors of minimum dietary diversity. The stakeholders, including the Ministry of Health, regional health offices, and agricultural sectors, prioritize enhancing child nutrition through targeted food-based approaches. Developing and implementing comprehensive intervention programs to improve children’s minimum dietary diversity (MDD) should be a central focus. Professionals should strengthen nutrition education to promote optimal MDD practices.
Sesamin alleviates lipid accumulation induced by elaidic acid in L02 cells through TFEB regulated autophagy
Authors: Liang Xueli , Zhang Tianliang , Cheng Xinyi , Yuan Hang , Yang Ning , Yi Yanlei , Li Xiaozhou , Zhang Fengxiang , Sun Jinyue , Li Zhenfeng , Wang Xia 
Published: December 2024

IntroductionNon-alcoholic fatty liver disease (NAFLD) is a common chronic disease seriously threatening human health, with limited treatment means, however. Sesamin, a common lignan in sesame seed oil, exhibits anti-inflammatory, antioxidant, and anticancer properties. Our previous studies have shown an ameliorative effect of sesamin on lipid accumulation in human hepatocellular carcinoma (HePG2) induced by oleic acid, with its protective effects unclear in the case of 9-trans-C18:1 elaidic acid (9-trans-C18,1).MethodsL02 cells, an important tool in scientific researches due to its high proliferation ability, preserved hepatocyte function, and specificity in response to exogenous factors, were incubated with 9-trans-C18:1 to establish an in vitro model of NAFLD in our study. The lipid accumulation in cells and the morphology of mitochondria and autolysosomes were observed by Oil Red O staining and transmission electron microscopy. The effects of sesamin on oxidative stress, apoptosis, mitochondrial function, autophagy as well as related protein levels in L02 cells were also investigated in the presence of 9-trans-C18:1.ResultsThe results showed that sesamin significantly accelerated the autophagy flux of L02 cells induced by 9-trans-C18:1 as well as elevated protein levels of transcription factor EB (TFEB) and its downstream target lysosome-associated membrane protein 1(LAMP1), along with up-regulated levels of TFEB and LAMP1 in the nucleus indicated by Immunofluorescence. In addition, PTEN-induced putative kinase 1 and Parkin mediated mitophagy was activated by sesamin. The direct inhibitor Eltrombopag and indirect inhibitor MHY1485 of TFEB reversed the protective effect of sesamin, suggesting the involvement of autophagy in the lipid-lowering process of sesamin.DiscussionThis work suggests that sesamin regulates autophagy through TFEB to alleviate lipid accumulation in L02 cells induced by 9-trans-C18:1, providing a potential target for the prevention and treatment of NAFLD.
Detection of aberrant locomotor activity in a mouse model of lung cancer via home cage monitoring
Authors: Tomanelli Michele , Guffanti Federica , Vargiu Giulia , Micotti Edoardo , Rigamonti Mara , Tumiatti Francesca , Caiola Elisa , Marabese Mirko , Broggini Massimo 
Published: December 2024

IntroductionLung cancer is the first cause of cancer death in the world, due to a delayed diagnosis and the absence of efficacy therapies. KRAS mutation occurs in 25% of all lung cancers and the concomitant mutations in LKB1 determine aggressive subtypes of these tumors. The improvement of therapeutical options for KRASG12C mutations has increased the possibility of treating these tumors, but resistance to these therapies has emerged. Preclinical animal models permit the study of tumors and the development of new therapies. The DVC system was used to measure circadian activity changes indicative of lung cancer progression in KRAS and KRAS-LKB1 transgenic mouse models.Material and methodsKRAS and KRAS-LKB1 conditional transgenic animal models were bred and genotyped. The tumors were inducted using adeno-CRE-recombinase system. The mice were housed in a Digital Ventilated Cage (DVC®) rack measuring the locomotor activity continuously for 24/7. The progression of the tumors was monitored with MRI. The DVC system evaluated a reduction in animal locomotion during the tumor progression.ResultsKRAS and KRAS-LKB1 mutations were induced, and the tumor formation and progression were monitored over time. As expected, the onset of the tumors in the two different breeds occurred at different times. DVC system registered the locomotion activity of the mice during the light and dark phases, reporting a strong reduction, mainly, in the dark phase. In KRAS-LKB1 models, the locomotion reduction appeared more pronounced than in KRAS models.DiscussionsTransgenic animal models represent a fundamental tool to study the biology of cancers and the development of new therapies. The tumors induced in these models harbor the same genotypical and phenotypical characteristics as their human counterparts. DVC methods permit a home cage monitoring system useful for tracking animal behavior continuously 24 hours a day, 7 days a week. DVC system could determine disease progression by monitoring a single animal activity in a cage and also using group-housed animals. For these reasons, the DVC system could play a crucial role in identifying diseases at early stages and in testing new therapeutic approaches with a higher likelihood of efficacy.
Bibliometric study on the utilization of sorafenib in hepatocellular carcinoma
Authors: Meng Wenjun , Luo Yihang , Zhao Lu , Zhang Yaoyu , Liu Jiyan , Li Shadan , Du Yang , Li Hongshuai 
Published: December 2024

BackgroundAlthough the number of studies on sorafenib for hepatocellular carcinoma (HCC) is increasing during the past two decades, no detailed scientometric examination of its knowledge framework has been undertaken. Therefore, we performed a bibliometric analysis on this topic.MethodsVOSviewer and CiteSpace were utilized to analyze the articles regarding sorafenib for HCC from 2005 to 2024, which were retrieved from the Web of Science Core Collection (WoSCC) database.ResultsThere were 7,667 articles related to sorafenib in HCC were retrieved from the WoSCC database, and they covered 99 countries/regions, 5,640 institutions, and 30,450 authors. The most published literature of countries and institutions were China and Sun Yat-sen University, respectively. Cancers is the journal with the most papers published in this field, and the journal with the most co-citations is N Engl J Med. Among authors, Masatoshi Kudo has published the most research papers, and the most co-citations go to JM Llovet. The keywords “survival”, “apoptosis”, “efficacy”, “transarterial chemoembolization”, “lenvatinib”, etc. represent the current hotspots in this field.ConclusionsWe identified current hotspots and trends by bibliometric analysis in sorafenib-HCC field, which might provide valuable guidance for future researches. Further explorations are supposed to conduct the continued study of HCC apoptosis, large-scaled clinical trials with international cooperations, and comprehensive treatments including multiple systemic or locoregional approaches in patients with HCC.