bluuebunny/crossref_metadata_2025_split huggingface dataset:
A clinical study on single-dose intravenous iron therapy’s impact on hemoglobin and its outcomes in hospitalized chronic kidney disease patients
Authors: Yadav Poshan , Narendra Varma J  , Goutham Krishna K  , Noufal Rizhwan H  , Satheesh Kumar E. , Padma L 
Published: December 2024

Anemia is a common complication in Chronic Kidney Disease (CKD) due to reduced erythropoietin production and iron deficiency, leading to poor patient outcomes. Intravenous (IV) iron therapy is preferred over oral supplements for its efficacy in rapidly improving hemoglobin levels and replenishing iron stores. Single-dose IV iron formulations like Ferric Carboxymaltose offer a convenient and effective option for anemia management in Chronic Kidney Disease (CKD) patients. Study on single-dose intravenous iron therapy’s impact on hemoglobin and its outcomes in hospitalized chronic kidney disease patients. A cross-sectional study was conducted on 200 hospitalized Chronic Kidney Disease (CKD) patients receiving single-dose IV iron therapy (Ferric Carboxymaltose, Iron Sucrose, or Monoferric). Outcomes including hemoglobin improvement, iron parameters, adverse events, and cost-effectiveness were analyzed pre- and post-treatment.The majority of patients (59%) were over 50 years old, with males accounting for 55% of the study group. The most prevalent comorbidities were Hypertension (91.5%) and type 2 diabetes (51%). The average Body Mass Index (BMI) reduced from 22.8 to 21.2 after the intervention. The most commonly provided iron formulation was Ferric Carboxymaltose (69.5%), followed by iron sucrose (16.5%) and Monoferric (14%). Hemoglobin levels rose by an average of 2.3 units in 51.5% of patients, with a mean time to target of 5.1 days. Ferritin levels increased by 41.4% after therapy, whereas TIBC and transferrin saturation remained stable. Hypertension was the most common side effect, with 74 cases documented (23 mild, 43 moderate, and 8 severe). The study found that Single-Dose Intravenous Iron therapy increases hemoglobin levels and Iron parameters in CKD patients, with Ferric Carboxymaltose being the most effective formulation. The medication also reduced post-hemodialysis BMI and was cost-effective for anemia management. The most common comorbidity was hypertension, and while there were some adverse events, they were largely controlled. Overall, Intravenous Iron therapy reduced anemia and its associated hazards, leading to better patient outcomes in Chronic Kidney Disease (CKD) care.
HUKUM EKONOMI SYARIAH TERHADAP PENGUASAAN HAK MILIK TANAH TANPA IZIN
Authors: Astuti Linda Dwi , Rochmiatun Siti 
Published: December 2024

Review of Sharia Economic Law on Control of Land Ownership Rights Without Permits in Tanjung Seteko Village, Indralaya District, Ogan Komering Ilir Regency. Land plays such an important role in every human life and business that it is possible for disputes to arise regarding land rights. Therefore, many people want to control or utilize land without the consent of the land owner. The problems in this research are: 1. What factors are behind the control of land ownership rights without permission in Tanjung Seteko Village, Indralaya District, Ogan Komering Ilir Regency? 2. What is the review of Sharia Economic Law regarding the control of land ownership rights without permission in Tanjung Seteko Village, Indralaya District, Ogan Komering Ilir Regency? This research uses field research methods. This research used a population of 94 people and a sample of 9 people. The data sources used are primary data and secondary data. Data collection techniques consist of interviews, observation and documentation. The data analysis technique uses descriptive qualitative. The results of this research show that 1. what factors are behind the control of property rights without permission in Tanjung Seteko Village, namely the low level of understanding of land control without permission, economic factors and negligence of land owners. 2. How does Sharia Economic Law review the control of land ownership rights without permission in Tanjung Seteko Village, which is haram and not permitted because it is an act of Ghasab. Because he has controlled someone else's land without any rights. In Sharia Economic Law, control of property rights without permission in Tanjung Seteko Village, namely does not fulfill the Principles of Justice and the Principles of Benefit. Actions carried out by land managers cause injustice to the land owner, and the land does not provide benefits in terms of the land owner or the surrounding community.
PEMBERDAYAAN ANGGOTA PKK DALAM PELATIHAN PEMBUATAN PROL TAPE DI DESA PENAMBANGAN, KECAMATAN CURAHDAMI, KAPUBATEN BONDOWOSO
Authors: Purbasari Dian , Sofiyah Siti 
Published: December 2024

Desa Penambangan merupakan desa yang terletak di Kecamatan Curahdami Kabupaten Bondowoso. Mayoritas penduduk yang merupakan anggota PKK Desa Penambangan berprofesi sebagai penjual tape. Sebagian besar penjual tape singkong di Desa Penambangan menjual tape secara langsung atau dalam kondisi setengah jadi tanpa diolah menjadi produk yang lebih menarik. Melihat kondisi tersebut maka kegiatan pengabdian masyarakat ini melakukan pelatihan pembuatan produk prol tape pada anggota PKK Desa Penambangan tersebut. Tujuannya adalah untuk meningkatkan wawasan masyarakat di desa tersebut mengenai pengolahan produk tape dan meningkatkan keterampilan dalam pembuatan diversifikasi tape menjadi prol tape dengan nilai jual yang lebih tinggi. Metode pengabdian ini dilakukan dengan menggunakan metode diskusi dan praktek dalam beberapa tahapan yaitu persiapan, pelaksaanaan pengabdian dan evaluasi. Hasil pengabdian masyarakat ini yaitu anggota PKK sebagai peserta pelatihan dalam program pengabdian ini sangat antusias dalam praktek pembuatan produk prol tape, selain itu peserta menjadi mempunyai keterampilan dalam pembuatan produk prol tape, sehingga dapat terus menghasilkan produk yang mempunyai nilai jual lebih tinggi.
INOVASI PEMBUATAN SISTEM INFORMASI KESEHATAN MASYARAKAT GUNA MENCIPTAKAN LINGKUNGAN TANGGUH COVID-19
Authors: Zain Adi Pradana Rahmatullah , Dharmayanti Agustin Wulan Suci 
Published: December 2024

Pandemi Covid-19 merupakan wabah virus baru yang menyerang seluruh dunia sejak tahun 2019. Yang menyebabkan negara-negara seluruh dunia harus melakukan tindakan prefentif hingga tindakan cepat dan tepat untuk melawan virus Covid-19. Agar dapat menghindari jatuhnya korban yang banyak karena virus baru ini. Salah satu tindakan yang dilakukan adalah dengan penerapan protokol kesehatan, yaitu 3M (Memakai Masker, Mecuci Tangan, dan Menjaga Jarak). Dimana fungsinya adalah untuk menekan risiko penularan Covid-19 yang semakin cepat. Selain itu juga dibutuhkan inovasi-inovasi baru agar dapat terus menekan penularan Covid-19 dan mengurangi dampak Covid-19. Salah satunya bertepatan dengan program KKN Back to Village II Universitas Jember. Dimana bagian dari tugas Universitas Jember adalah melakukan pengabdian dimasyarakat. Dengan adanya program ini mahasiswa Universitas Jember menciptakan inovasi subuah Sistem Informasi Kesehatan Masyarakat, yang berfungsi meningkatkan kesadaran dan kepedulian masyarakat akan kesehatan ditengah kondisi pandemi Covid-19. Pada kegiatan yang berada di RT 06 RW 09 Kelurahan Patrang sebagai tempat sasaran dijalankanya program KKN ini. Mahasiswa mengadakan sosialisasi hingga pelatihan dan pendampingan program Sistem Informasi Kesehatan Masyarakat. Dimana ada tiga item atau program yang dijelaskan kepada masyarakat yaitu Alur Informasi Kesehatan Masyarakat, Kartu Informasi Kesehatan Masyarakat, dan Iuran Masyarakat. Dengan penerapan semua program tersebut, diharapkan dapat menciptakan Lingkungan Tangguh Covid-19. Yang mana didahului dengan pengertian dan pemahaman serta kesadaran masyarakat dalam menjaga kesehatan diri mereka, baik pribadi, keluarga dan lingkungan sekitar. Sehingga ketika semua elemen dalam masyarakat dapat bergerak bersama menerapkan Sistem Informasi Kesehatan Masyarakat di lingkungan mereka. Diharapkan dapat menekan risiko penularan Covid-19, dan memitigasi dampak dari Covid-19.
Reformulasi Prapenuntutan dalam KUHAP untuk Mewujudkan Asas Sederhana, Cepat dan Biaya Ringan dalam KUHAP In-Constituendum
Authors: Amrullah M. Arief 
Published: December 2024

Ketika lahirnya KUHAP sebagaimana diatur dalam Undang-Undang No. 8 tahun 1981 telah diujikan sebagai karya agung bangsa Indonesia yang menggantikan Hukum Acara Pidana yang diatur dalam Het Herziene Inlandsch Reglement (HIR). Karena, ketentuan dalam HIR orientasinya memandang tersangka atau terdakwa sebagai obyek dan bukan subyek. Itulah latar belakang lahirnya KUHAP. Salah satu ketentuan yang diatur dalam KUHAP adalah mengenai prapenuntutan yang dalam perkembangannya memerlukan untuk dilakukan reformulasi. Karena, proses prapenuntutan dalam KUHAP telah menghadirkan permasalahan adanya ketidak pastian hukum dengan bolak-baliknya berkas perkara dari penyidik ke penuntut umum menjadikan proses tersebut menjadi rumit dan menyita waktu yang relatif lama untuk sampai dilimpahkan ke pengadilan. Kondisi ini sangat merugikan para pencari keadilan (korban). Upaya reformulasi telah dilakukan dalam RUU KUHAP, namun belum berorientasi pada asas sederhana, cepat dan biaya ringan. Demikian juga, dalam Putusan MK. No. 130/PUU-XIII/2015. Tujuan penulisan artikel ini adalah untuk mereformulasi ketentuan prapenuntutan yang berorientasi pada asas sederhana, cepat dan biaya ringan sebagaimana diamanatkan dalam KUHAP dan Undang-Undang No. 48 Tahun 2009. tentang Kekuasaan Kehakiman. Adapun metode yang digunakan dalam penelitian untuk penulisan artikel ini, menggunakan legal research (desk research). Hasil dari penelitian ini, bahwa ketentuan yang mengatur mengenai prapenuntutan belum menjamin adanya kepastian hukum, sehubnungan dengan bolak-baliknya berkas perkara dari penyidik ke penuntut umum, akibatnya cenderung merugikan kepentingan pencari keadilan. Karena itu ke depan ketentuan mengenai prapenuntutan sudah seharusnya berbasis pada asas sederhana, cepat dan biaya ringan, dan agar lebih menunjang asas tersebut dalam proses prapenuntutan perlu beradaftasi dengan teknologi informasi.
Expression of ALKBH3 and its effects on proliferation, migration, and invasion of lung adenocarcinoma A549 cells: bioinformatics analysis and in vitro and in vivo experiments
Authors: Zhang Song , Chen Haoyu , Liu Tao , Qin Chao , Yan Hang , Hu Haiyang , Tang Shengjie , Dai Tingting , Ji Danyu , Yang Li , Zhou Haining 
Published: December 2024

Objective: To use bioinformatics analysis and in vitro and in vivo experiments to study the biological role of ALKBH3 in lung adenocarcinoma.
Methods: Bioinformatics analysis of ALKBH3 was performed using databases. ALKBH3 expression in lung adenocarcinoma and adjacent tissues was detected by qPCR (quantitative polymerase chain reaction), western blotting, and immunohistochemistry. Stable transformed A549 cells with low expression of ALKBH3 were constructed. The effects of knockdown of ALKBH3 on the proliferation, migration, and invasion of lung adenocarcinoma A549 cells were detected by CCK-8, cell scratch, and transwell invasion assays, respectively. The effects of ALKBH3 on the proliferation of A549 cells in vivo were detected using subcutaneous tumorigenesis in nude mice.
Results: Bioinformatics analysis showed that ALKBH3 has diagnostic value in tumors such as lung adenocarcinoma, the expression of ALKBH3 is related to immune cell infiltration, ALKBH3 interacts with ASCC family molecules, and ALKBH3 is involved in the demethylation of DNA and RNA. The expression of ALKBH3 in lung adenocarcinoma was higher than that in adjacent tissues (P < 0.05). CCK-8, wound healing and transwell assays showed that ALKBH3 knockdown significantly inhibited the proliferation, migration, and invasion of A549 cells in vitro (P < 0.01). ALKBH3 knockdown also significantly inhibited the growth of subcutaneous tumors in nude mice (P < 0.01).
Conclusions: ALKBH3 is a potential diagnostic marker for lung adenocarcinoma. Results in vivo and in vitro showed that knocking down ALKBH3 could inhibit the proliferation, migration, invasion, and subcutaneous tumorigenesis of lung adenocarcinoma A549 cells.
Mechanisms of immunotherapy resistance in small cell lung cancer
Authors: Nie Yunan , Schalper Kurt A. , Chiang Anne 
Published: December 2024

Small-cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with a poor prognosis. Although the addition of immunotherapy to chemotherapy has modestly improved outcomes, most patients rapidly develop resistance. Resistance to immunotherapy can be broadly categorized into primary resistance and acquired resistance, as proposed by the Society for Immunotherapy of Cancer (SITC) consensus definition. Primary resistance occurs in the setting of failure to respond to immune checkpoint inhibitors (ICIs), while acquired resistance develops after initial response. The mechanisms of acquired and primary resistance to ICI are not well understood in SCLC, denoting an area of critical unmet need.
Both intrinsic and extrinsic mechanisms play significant roles in immunotherapy resistance. Intrinsic mechanisms include defects in antigen presentation, mutations in key genes, reduced tumor immunogenicity, and epigenetic alterations. Extrinsic mechanisms involve the tumor microenvironment (TME), which is a complex interplay of both tumor- and immunosuppressive immune cells, vasculature, and microbiome.
An understanding of these resistance mechanisms is crucial for developing novel therapeutic strategies to advance effective immunotherapy in patients with SCLC, a critical area of unmet need.
Entropy harvest and key derivation from the image sensors in IP camera
Authors: Ryu Jieun , Kim Gwangjae , Ko Jeongbeen , Kang Dongkeun , Kang Ju-Sung , Yeom Yongjin 
Published: December 2024

With the widespread use of connected surveillance systems using IP cameras, the security of video data has become a critical issue. In response to the potential compromise of sensitive information via covert channels, the United States and the United Kingdom warned against the use of suspicious cameras in critical infrastructure. To mitigate the security concerns, it is indispensable to investigate every component inside IP cameras using evaluation and validation programs such as Common Criteria and Cryptographic Module Validation Program. However, such compliance tests on implementation under test cannot suffice to prevent the products from malicious attacks using a Trojan-horse in a black-box component, particularly inserted in the image-sensing module or the random number generator (RNG).
In this paper, we categorize potential vulnerabilities and argue that IP cameras should disclose the components of the modules to mitigate the threats of backdoor. Based on this, we provide a way to construct backdoor-free RNG. To remove the possibility of the backdoor inside the RNG, we extract randomness from optical black pixels of the image sensor and apply two entropy accumulation methods to guarantee the min-entropy of accumulated data under weak assumptions, which means the IP camera already has a hardware entropy source in itself without additional suspicious entropy source. In the experiment using an IP camera with a Cortex-A53 processor, we can harvest entropy at the rate of 7.3kbps. The operating speed of the RNG is sufficient to provide random bits without delay when a symmetric key is updated every minute.
Barriers to the provision of youth-friendly services for adolescents living with HIV and AIDS
Authors: Mashamba Langanani , Letswalo Lucky , Mkhonto Flora , Ramalepa Tshiamo 
Published: December 2024

Adolescents living with HIV and AIDS experience difficulties when they transition from pediatric clinics to adult clinics. People living with HIV and AIDS have been judged and stigmatized as promiscuous. Since adolescence is a challenging milestone with all the physical and emotional changes, adolescents become vulnerable to defaulting care and treatment at the clinic. In some health facilities, youth-friendly services are still not well implemented, despite the program being advocated for by the World Health Organization to reduce HIV. The study aimed to explore the barriers to the provision of youth-friendly services for adolescents living with HIV and AIDS in clinics in Gauteng Province, South Africa. An explorative descriptive and qualitative design was applied through in-depth interviews. Data were collected from 15 professional nurses in three clinics and analysed using the content analysis framework. The study's findings produced five themes: human resource challenges, inadequate space to provide the service, healthcare providers’ attitudes toward the provision of mixed services and an environment not conducive to the service. Healthcare providers displayed judgemental attitudes towards adolescents when they sought sexual and reproductive services at the clinics. The shortage of staff and resources hampered the provision of youth-friendly services to adolescents living with HIV and AIDS. Lack of privacy and confidentiality due to limited space in the clinics caused adolescents to default on their treatment as they are seen in the same space as adults. The study recommends a designated area for adolescents and youth separated from other clinic populations so that sexual and reproductive health topics can be discussed without fear of being identified by other people visiting the clinic. Moreover, more youth-inclusive environments in healthcare settings should be created.
PENGARUH KOMUNIKASI PEMASARAN DAN SERVICE QUALITY TERHADAP BRAND AWARENESS PADA WISATA AIR TERJUN JANTUR DOYAM DI KABUPATEN BARITO UTARA
Authors: Irawati Gina Sonia , Naparin Muhammad , Indrayatie Eko Rini 
Published: December 2024

North Barito Regency is known as one of the districts in Central Kalimantan Province with the capital being Muara Teweh. Jantur Doyam Waterfall is one of the leading tourist attractions in North Barito Regency which can be visited and is equipped with quite complete tourist facilities. However, this leading tourist attraction in North Barito Regency seems very empty of visitors because of the new tourist attractions which have created a desire to visit new places. Therefore, it is hoped that this research can show that effective marketing communications can help introduce tourism to visitors and good quality service can provide a satisfying experience, thereby creating top of mind Brand Awareness to increase the number of visits to the Jantur Doyam Waterfall tourist attraction. The purpose of this research is to determine the effect of marketing communications on brand awareness at Jantur Doyam Waterfall tourism and to determine the effect of service quality on brand awareness at Jantur Doyam Waterfall tourism. This research was carried out at Jantur Doyam Waterfall which is located in Mukut Village, Lahei District, North Barito Regency, Central Kalimantan Province. The method used in this research is a quantitative method using interviews and using the Smart-PLS 3 application. From the results of this research it was found that marketing communication variables have a significant effect on brand awareness and service quality also has a significant effect on brand awareness because it has a P-value less than 0, 05.
MATHEMATICAL MODEL AND OPTIMIZATION ALGORITHM ACCORDING TO THE CRITERIA OF MINIMUM CONTACT STRESS FOR INVOLUTE SPUR GEARS WITH INCREASED CONTACT RATIO
Authors: Cherelev Stanislav , Ustynenko Oleksandr , Bošanský Miroslav , Protasov Roman , Bondarenko Oleksiy , Andrienko Sergij 
Published: December 2024

Reducing the mass and dimensions of involute spur gears is an actual task of modern mechanical engineering. One of the perspective ways to solve it is the use of gearing with an increased working tooth depth and profile contact ratio εα ≥ 2. The study is devoted to the development of optimal design methods for such gears. Optimality criteria is formulated as follows: the contact stresses in the pitch point must take a minimum value when all constructive, geometric, kinematic, and technological constraints are met, first, when the profile contact ratio εα ≥ 2 is ensured. Variables planning are defined. These are addendum coefficients of the basic racks tooth for pinion and wheel h*a1, h*a2; profile angle of the basic rack α; addendum modification coefficient of the pinion x1. Formed a system of constraints for the variables planning: the main functional constraint of the minimum value of the profile contact ratio: εα ≥ 2; constraint for the addendum coefficients of the basic racks tooth for pinion and wheel h*a1, h*a2; constraint for profile angle of the basic rack α; constraint for addendum modification coefficients x1, x2; absence of the cutter interference for tooth dedendum; absence of the sharpening for tooth addendum; absence of the mesh interference; ensuring the bending strength of pinion and wheel teeth. A method for solving the problem of optimal design is chosen. The method of probing the space of design parameters was chosen from all the variety. The points of the LPτ-sequence are used as test points. The method allows you to operate with a significant number of parameters – up to 51, provides a sufficiently large number of evenly distributed test points – up to 220. The algorithm for optimal design of gear has been developed. The main stages of the algorithm are as follows: setting input data (numerical constraints on design variables, gear parameters and its load); generation of LPτ-sequence for variables planning with simultaneous consideration of their numerical constraints; checking of functional constraints; additional verification calculations (if necessary) of the gearing contact strength; formation of an array of possible solutions; searching of the best solution variant (the test point corresponding to the minimum value of the objective function) by sorting the array.
Pengaruh ESG Disclosure Terhadap Kinerja Keuangan Perusahaan: Sustainability Committee Sebagai Pemoderasi
Authors: Silviani Amanda Agnes , Kamaliah Kamaliah , Wiguna Meilda 
Published: December 2024

<p><em>Environmental, Social, and Governance (ESG) disclosure has become increasingly important in recent years as investors become more aware of the company's impact on society and the environment. Sustainability committees play a crucial role in this process as they are responsible for ensuring that a company's ESG practices are transparent and aligned with its overall strategy. This research examines the relationship between ESG disclosure and company financial performance, with the Sustainability Committee as a moderating variable. The study focuses on 205 non-financial public companies listed on the Indonesia Stock Exchange from 2019 to 2023, using panel data analysis with STATA version 17. The findings reveal a positive correlation between ESG disclosure and financial performance, where higher levels of ESG transparency lead to better financial results. The Sustainability Committee strengthens this relationship, pointing out that its presence significantly affects the impact of ESG disclosures on financial performance.</em></p>