bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing floral resource maps and land cover maps to predict predators and aphid suppression on field bean
Authors: Ammann Lolita , Bosem-Baillod Aliette , Eckerter Philipp W. , Entling Martin H. , Albrecht Matthias , Herzog Felix 
Published: November 2021

Abstract
Context
Predatory insects contribute to the natural control of agricultural pests, but also use plant pollen or nectar as supplementary food resources. Resource maps have been proposed as an alternative to land cover maps for prediction of beneficial insects.

Objectives
We aimed at predicting the abundance of crop pest predating insects and the pest control service they provide with both, detailed flower resource maps and land cover maps.

Methods
We selected 19 landscapes of 500 m radius and mapped them with both approaches. In the centres of the landscapes, aphid predators – hoverflies (Diptera: Syrphidae), ladybeetles (Coleoptera: Coccinellidae) and lacewings (Neuroptera: Chrysopidae) – were surveyed in experimentally established faba bean phytometers (Vicia faba L. Var. Sutton Dwarf) and their control of introduced black bean aphids (Aphis fabae Scop.) was recorded.

Results
Landscapes with higher proportions of forest edge as derived from land cover maps supported higher abundance of aphid predators, and high densities of aphid predators reduced aphid infestation on faba bean. Floral resource maps did not significantly predict predator abundance or aphid control services.

Conclusions
Land cover maps allowed to relate landscape composition with predator abundance, showing positive effects of forest edges. Floral resource maps may have failed to better predict predators because other resources such as overwintering sites or alternative prey potentially play a more important role than floral resources. More research is needed to further improve our understanding of resource requirements beyond floral resource estimations and our understanding of their role for aphid predators at the landscape scale.
What difference does multiple imputation make in longitudinal modeling of EQ-5D-5L data? Empirical analyses of simulated and observed missing data patterns
Authors: Rösel Inka , Serna-Higuita Lina María , Al Sayah Fatima , Buchholz Maresa , Buchholz Ines , Kohlmann Thomas , Martus Peter , Feng You-Shan 
Published: November 2021

Abstract
Purpose
Although multiple imputation is the state-of-the-art method for managing missing data, mixed models without multiple imputation may be equally valid for longitudinal data. Additionally, it is not clear whether missing values in multi-item instruments should be imputed at item or score-level. We therefore explored the differences in analyzing the scores of a health-related quality of life questionnaire (EQ-5D-5L) using four approaches in two empirical datasets.

Methods
We used simulated (GR dataset) and observed missingness patterns (ABCD dataset) in EQ-5D-5L scores to investigate the following approaches: approach-1) mixed models using respondents with complete cases, approach-2) mixed models using all available data, approach-3) mixed models after multiple imputation of the EQ-5D-5L scores, and approach-4) mixed models after multiple imputation of EQ-5D 5L items.

Results
Approach-1 yielded the highest estimates of all approaches (ABCD, GR), increasingly overestimating the EQ-5D-5L score with higher percentages of missing data (GR). Approach-4 produced the lowest scores at follow-up evaluations (ABCD, GR). Standard errors (0.006–0.008) and mean squared errors (0.032–0.035) increased with increasing percentages of simulated missing GR data. Approaches 2 and 3 showed similar results (both datasets).

Conclusion
Complete cases analyses overestimated the scores and mixed models after multiple imputation by items yielded the lowest scores. As there was no loss of accuracy, mixed models without multiple imputation, when baseline covariates are complete, might be the most parsimonious choice to deal with missing data. However, multiple imputation may be needed when baseline covariates are missing and/or more than two timepoints are considered.
Is there a gender gap in equity-based crowdfunding?
Authors: Prokop Jörg , Wang Dandan 
Published: November 2021

AbstractCompared to their male peers, female entrepreneurs tend to face greater obstacles in raising venture funding from business angels, venture capitalists, and financial institutions. In this paper, we investigate whether this gender gap also exists in equity crowdfunding. Based on data from the German equity crowdfunding market, we find that ventures with and without female managing directors are equally successful in raising capital when launching their first equity crowdfunding campaign. In contrast, the former are significantly less successful than their peers in seasoned equity crowdfunding campaigns, and this disparity cannot be fully explained by differences in other venture-related or entrepreneur-related characteristics. However, we also find that the gender gap in seasoned offerings narrows if female entrepreneurs set more ambitious funding thresholds. Overall, our results indicate that pitching their equity crowdfunding campaigns in a more promotion-oriented way is a sensible strategy for female entrepreneurs to improve funding success.
A comparison of systematic reviews and guideline-based systematic reviews in medical studies
Authors: Schniedermann Alexander 
Published: November 2021

AbstractThe question of how citation impact relates to academic quality accompanies every decade in bibliometric research. Although experts have employed more complex conceptions of research quality for responsible evaluation, detailed analyses of how impact relates to dimensions such as methodological rigor are lacking. But the increasing number of formal guidelines for biomedical research offer not only the potential to understand the social dynamics of standardization, but also their relations to scientific rewards. By using data from Web of Science and PubMed, this study focuses on systematic reviews from biomedicine and compares this genre with those systematic reviews that applied the PRISMA reporting standard. Besides providing an overview about growth and location, it was found that the latter, more standardized type of systematic review accumulates more citations. It is argued that instead of reinforcing the traditional conception that higher impact represents higher quality, highly prolific authors could be more inclined to develop and apply new standards than more average researchers. In addition, research evaluation would benefit from a more nuanced conception of scientific output which respects the intellectual role of various document types.
Semantic theories, linguistic essences, and knowledge of meaning
Authors: Haverkamp Nick , Hoeltje Miguel 
Published: November 2021

AbstractThis paper argues, first, that the information problem poses a foundational challenge to mainstream semantics. It proposes, second, to address this problem by drawing on notions from Kit Fine’s essentialist framework. More specifically, it claims that the information problem can be avoided by strengthening standard truth theories, employing an operator expressing the notion of a relative constitutive semantic requirement. As a result, the paper proposes to construe semantic theories as theories of semantic requirements, and semantic knowledge as knowledge of such requirements.
REASSESSMENT OF UNCERTAINTY EXPANSION BY LINEAR ADDITION OF LONG-TERM COMPONENTS FROM TOP-DOWN INFORMATION
Authors: Salazar G , Szidat S 
Published: November 2021

ABSTRACTSince radiocarbon accelerator mass spectrometry (14C AMS) is considered a high-precision technique, reassessment of the measurement uncertainty has been a topic of interest. Scientists from analytical and metrological fields have developed the top-down and bottom-up measurement of uncertainty approaches. The 14C quoted error should approximate the uncertainty of long-term repetitions of the top-down approach in order to be realistic. The novelty of this paper is that the uncertainty of both approaches were approximated to each other. Furthermore, we apportioned the graphitization, instrumentation, and bias components in order to additively expand the quoted error. Our results are comparable to error multipliers and to long-term repeatability studies reported by other laboratories. Our laboratory was established in late 2012 with N2 as stripper gas and 7 years later, we changed to helium stripper. Thus, we were able to compare both gases, and demonstrate that helium is a better stripper gas. In absolute F14C units, the ranges of graphitization+bias combined uncertainties were (0.7 to 4.1) × 10–3 for N2 and (0.7–3.0) × 10–3 for He depending on the standard 14C content. The error multiplier for He defined as the expanded uncertainty over quoted error, in average, was 1.7; while without the bias, the multiplier was 1.3.
Fifty years of woodworkers’ nasal adenocarcinoma in High Wycombe
Authors: Capper J W R 
Published: November 2021

AbstractBackgroundSince adenocarcinoma of the ethmoid sinuses was first described as an occupational disease in the woodworkers of High Wycombe, over the 50 subsequent years there has been a gradual decrease in the numbers to none over the last 12 years. Although this mirrored the decline in local industry, it seems the causative factor was first seen and then disappears over a 50-year period.MethodsA total of 146 cases have been traced historically over this time as well as personal experience of 33 cases; these cases are reviewed and success with a new modality of treatment is discussed.ConclusionThis paper outlines how the disease was initially recognised, both its diagnosis and treatment development. It also describes how both the appearance and disappearance were seemingly caused by changes in manufacturing practice.
Relational mentalizing after any representation
Authors: Deschrijver Eliane 
Published: November 2021

Abstract
Autistic, developmental, and nonhuman primate populations fail tasks that are thought to involve attributing beliefs, but not those thought to reflect the representation of knowledge. Instead of knowledge representations being more basic than belief representations, relational mentalizing may explain these observations: The tasks referred to as reflecting “belief” representation, but not the “knowledge” representation tasks, are social conflict designs. They involve mental conflict monitoring after another's mental state is represented – with effects that need to be accounted for.
Exchanging humpty dumpties is not a solution: Why a representational view of knowledge must be replaced with an action-based approach
Authors: Carpendale Jeremy I. M. , Lewis Charlie 
Published: November 2021

Abstract
In arguing for knowledge representation before belief, Phillips et al. presuppose a representational theory of knowledge, a view that has been extensively criticized. As an alternative, we propose an action-based approach to knowledge, conceptualized in terms of skill. We outline the implications of this approach for children's developing social understanding, beginning with sensorimotor interaction and extending to the verbal level.
The left atrial appendage congenital aneurysm in a two-year-old child: a case report
Authors: Zalewska Luiza , Gęca Grzegorz , Stanek Piotr 
Published: November 2021

AbstractThe left atrial appendage congenital aneurysm is an extremely rare heart defect. The entity can remain asymptomatic for a long time; however, it may lead to life-threatening morbidity or death.
The role of organization of care in GPs’ prevention practice
Authors: Delpech Raphaëlle , Poncet Lorraine , Gautier Arnaud , Panjo Henri , Ourabah Rissane , Mourey Pascaline , Baumhauer Mathilde , Pendola-Luchel Isabelle , Ringa Virginie , Rigal Laurent 
Published: November 2021

Abstract

Background:
General practitioners (GPs) do not systematically include preventive recommendations in their practice, and some characteristics of health care organization are associated with more systematic prevention. But the characteristics of health care organization may act in a nonuniform manner depending on the type of preventive care. Thus, one characteristic can be positively associated with one type of preventive care and negatively associated with another. Our aim was to investigate the association between health care organization in general practice and different areas of preventive care (immunization and addiction prevention), in search of nonuniform associations.

Methods:
We used a representative survey of 1,813 French GPs conducted in 2009. Four preventive care practices were studied: immunization through flu and HPV vaccination, and prevention of addictive behaviors concerning tobacco and alcohol use.
Characteristics of GPs’ health care organization and the social context of their practice were collected (spatial accessibility to GPs and socioeconomic level of the area of practice). We constructed mixed models to study associations and interactions between the organization variables and preventive care.

Results:
Four out of five characteristics of GPs’ organization have uneven impacts on different types of preventive care (p-interaction < 10-4). For example, number of daily consultations is associated with better immunization prevention but with poorer prevention counseling in addictive behaviors. In contrast, working with digital medical files is uniformly associated with both types of preventive care (OR = 1.29 [1.15–1.45]; P < 10-4).

Conclusion:
An approach centered on specific types of preventive care should help deepen our understanding of prevention and possibly help to identify a new typology for preventive care.
FOLASP: FO(·) as Input Language for Answer Set Solvers
Authors: VAN DESSEL KYLIAN , DEVRIENDT JO , VENNEKENS JOOST 
Published: November 2021

AbstractTechnological progress in Answer Set Programming (ASP) has been stimulated by the use of common standards, such as the ASP-Core-2 language. While ASP has its roots in nonmonotonic reasoning, efforts have also been made to reconcile ASP with classical first-order (FO) logic. This has resulted in the development of FO(·), an expressive extension of FO, which allows ASP-like problem solving in a purely classical setting. This language may be more accessible to domain experts already familiar with FO and may be easier to combine with other formalisms that are based on classical logic. It is supported by the IDP inference system, which has successfully competed in a number of ASP competitions. Here, however, technological progress has been hampered by the limited number of systems that are available for FO(·). In this paper, we aim to address this gap by means of a translation tool that transforms an FO(·) specification into ASP-Core-2, thereby allowing ASP-Core-2 solvers to be used as solvers for FO(·) as well. We present experimental results to show that the resulting combination of our translation with an off-the-shelf ASP solver is competitive with the IDP system as a way of solving problems formulated in FO(·).
Fragebogen zu psychologischen Einflussfaktoren der Nutzung von Pkw, ÖPNV und Fahrrad (PsyVKN)
Authors: Hunecke Marcel , Heppner Holger , Groth Sören 
Published: November 2021

Zusammenfassung. Zur Analyse der Ursachen für die interindividuelle Variabilität der Verkehrsmittelnutzung werden subjektive Bewertungen von Verkehrsmitteln im Rahmen standardisierter Verkehrserhebungen zunehmend mit berücksichtigt. Im vorliegenden Beitrag wird ein theoretisch fundierter und empirisch validierter Fragebogen zu den psychologischen Einflussfaktoren der Nutzung von Pkw, ÖPNV und Fahrrad (PsyVKN) im Alltag vorgestellt, der Items zu Kontrollüberzeugungen, verkehrsmittelbezogenen Normen und Einstellungen umfasst. Auf der empirischen Basis von sechs Studien mit 10 850 Befragten aus über neun Jahren psychologischer Mobilitätsforschung wurde, auf der Basis von Strukturgleichungsmodellen und Messinvarianzanalysen, ein ökonomisches, reliables und valides Messinstrument für psychologische Merkmale der Verkehrsmittelnutzung entwickelt. Als Ergebnis stehen acht psychologische Konstrukte mit 21 Items für die Anwendung in der interdisziplinären Verkehrs- und Mobilitätsforschung zur Verfügung. Die entsprechenden psychologischen Konstrukte können in Verkehrserhebungen zur Erfassung der interindividuellen Variabilität bei der Verkehrsmittelnutzung und darauf aufbauend zur Planung von Maßnahmen zur Reduktion der Automobilität im Nahverkehr eingesetzt werden.
Lebenskompetenzen als Ressourcen für die psychosomatische Behandlung
Authors: Hinterberger Thilo , Walter Nike , Galuska Joachim 
Published: November 2021

Zusammenfassung. Lebenskompetenzen stellen Fähigkeiten dar, aus denen eine salutogene Lebensführung resultiert. Dadurch können sie sowohl als Basis als auch als wichtiger Indikator für den therapeutischen Prozess dienen. Hier wird ein Selbsteinschätzungsinstrument vorgestellt, welches an N = 2 054 Patientinnen und Patienten der stationären psychosomatischen Behandlung erhoben wurde und dessen Konstrukt in zweifacher Erhebung exploratorisch und konfirmatorisch validiert wurde. Der Fragebogen LK-18 umfasst 18 Items, die sich in 6 Faktoren mit je 3 Items gliedern lassen. Diese sind Wohlbefinden, Selbstregulation, Engagement, Sinnerleben, Selbstwirksamkeit, sowie Sozialkontakte. Die Werte für Cronbachs α liegen zwischen .74 und .85, im Gesamtwert bei .91. Die RMSEA von .062 deutet auf eine akzeptable Modellpassung hin. Als externe Korrelate zeigen psychosomatische Symptombelastungen nach dem ICD10-basierten Symptomrating (ISR) und posttraumatische Störungen meist mittlere negative Korrelationen im Bereich -.22 bis -.69 ( p < .001). Die Ergebnisse demonstrieren die Validität des Fragebogens und seine Veränderungssensitivität, wodurch der Einsatz in der psychosomatischen Diagnostik als geeignetes Zusatzinstrument als sinnvoll erachtet werden kann.
GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages
Authors: Chen Jinhong , Lin Zhifei , Liu Lu , Zhang Rui , Geng Yan , Fan Minghao , Zhu Wenwei , Lu Ming , Lu Lu , Jia Huliang , Zhang Jubo , Qin Lun-Xiu 
Published: November 2021

AbstractThe immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses. Golgi membrane protein 1 (GOLM1) is correlated to hepatocellular carcinoma (HCC) progression and metastasis. However, little is known about the role of GOLM1 in regulating the immunosuppressive environment and its impact on immunotherapeutic efficacy in HCC. In this study, GOLM1 was positively correlated with infiltrating tumor-associated macrophages (TAMs) expressed high levels of programmed death-ligand 1 (PD-L1) and CD8+ T cell suppression in HCC tissues. Both gain- and loss-of-function studies determined a close correlation between GOLM1 and immunosuppression. In the mechanism, GOLM1 promoted COP9 signalosome 5-mediated PD-L1 deubiquitination in HCC cells and increased the transport of PD-L1 into exosomes via suppression of Rab27b expression. Furthermore, co-culture with exosomes derived from HCC cells upregulated the expression of PD-L1 on macrophages. Zoledronic acid in combination with anti-PD-L1 therapy reduced PD-L1+ TAMs infiltration and alleviated CD8+ T cell suppression, resulting in tumor growth inhibition in the mouse HCC model. Together, our study unveils a mechanism by which GOLM1 induces CD8+ T cells suppression through promoting PD-L1 stabilization and transporting PD-L1 into TAMs with exosome dependent. Targeting PD-L1+ TAM could be a novel strategy to enhance the efficacy of anti-PD-L1 therapy in HCC.
Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer
Authors: Gao Yaohui , Bi Dexi , Xie Ruting , Li Man , Guo Jing , Liu Hu , Guo Xianling , Fang Juemin , Ding Tingting , Zhu Huiyuan , Cao Yuan , Xing Meichun , Zheng Jiayi , Xu Qing , Xu Qian , Wei Qing , Qin Huanlong 
Published: November 2021

AbstractGiven that only a subset of patients with colorectal cancer (CRC) benefit from immune checkpoint therapy, efforts are ongoing to identify markers that predict immunotherapeutic response. Increasing evidence suggests that microbes influence the efficacy of cancer therapies. Fusobacterium nucleatum induces different immune responses in CRC with different microsatellite-instability (MSI) statuses. Here, we investigated the effect of F. nucleatum on anti-PD-L1 therapy in CRC. We found that high F. nucleatum levels correlate with improved therapeutic responses to PD-1 blockade in patients with CRC. Additionally, F. nucleatum enhanced the antitumor effects of PD-L1 blockade on CRC in mice and prolonged survival. Combining F. nucleatum supplementation with immunotherapy rescued the therapeutic effects of PD-L1 blockade. Furthermore, F. nucleatum induced PD-L1 expression by activating STING signaling and increased the accumulation of interferon-gamma (IFN-γ)+ CD8+ tumor-infiltrating lymphocytes (TILs) during treatment with PD-L1 blockade, thereby augmenting tumor sensitivity to PD-L1 blockade. Finally, patient-derived organoid models demonstrated that increased F. nucleatum levels correlated with an improved therapeutic response to PD-L1 blockade. These findings suggest that F. nucleatum may modulate immune checkpoint therapy for CRC.
FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation
Authors: Gultekin Okan , Gonzalez-Molina Jordi , Hardell Elin , Moyano-Galceran Lidia , Mitsios Nicholas , Mulder Jan , Kokaraki Georgia , Isaksson Anders , Sarhan Dhifaf , Lehti Kaisa , Carlson Joseph W. 
Published: November 2021

AbstractUterine sarcomas are rare but deadly malignancies without effective treatment. Immunotherapy is a promising new approach to treat these tumors but has shown heterogeneous effects in sarcoma patients. With the goal of identifying key factors for improved patient treatment, we characterized the tumor immune landscape in 58 uterine sarcoma cases with full clinicopathological annotation. Immune cell characterization revealed the overall prevalence of FOXP3+ cells and pro-tumor M2-like macrophages. Hierarchical clustering of patients showed four tumor type-independent immune signatures, where infiltration of FOXP3+ cells and M1-like macrophages associated with favorable prognosis. High CD8+/FOXP3+ ratio in UUS and ESS correlated with poor survival, upregulation of immunosuppressive markers, extracellular matrix (ECM)-related genes and proteins, and YAP activation. This study shows that uterine sarcomas present distinct immune signatures with prognostic value, independent of tumor type, and suggests that targeting the ECM could be beneficial for future treatments.