bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rectification of self-propelled cells in confluent tissues
Authors: Ai Bao-quan , Xu Guo-hao , Li Jia-jian , He Ya-feng 
Published: September 2021

Abstract
Collective cell transport in dense tissues governs many biological processes, such as embryonic development, cancer metastasis and wound healing. How to control the directed transport of cells in dense tissues is still an interesting and open question. We numerically investigated the directed transport of a confluent tissue containing self-propelled cells in an asymmetric periodic potential by using the self-propelled Voronoi model. We demonstrate that cells in the confluent tissue can be rectified and the movement direction of cells is determined by the asymmetry of the potential. The cell shape index determines the state of the system and plays a central role in the rectification. There exists an optimal shape index at which the average velocity takes its maximal value. Interestingly, there exist two optimal self-propulsion speeds at which the average velocity reaches its maximum, which is different from the single-cell case (only one optimal speed). In addition, the average velocity is a peaked function of the cell number for small shape index and monotonously decreases with the increase of the cell number for large shape index. Our findings are relevant to the experimental pursuit of the control of motile confluent tissues on periodic substrates.
Inheritance and flexibility of cell polarity: a clue for understanding human brain development and evolution
Authors: Kalebic Nereo , Namba Takashi 
Published: September 2021

ABSTRACTCell polarity is fundamentally important for understanding brain development. Here, we hypothesize that the inheritance and flexibility of cell polarity during neocortex development could be implicated in neocortical evolutionary expansion. Molecular and morphological features of cell polarity may be inherited from one type of progenitor cell to the other and finally transmitted to neurons. Furthermore, key cell types, such as basal progenitors and neurons, exhibit a highly flexible polarity. We suggest that both inheritance and flexibility of cell polarity are implicated in the amplification of basal progenitors and tangential dispersion of neurons, which are key features of the evolutionary expansion of the neocortex.
Exposure to low temperature prepares the turtle brain to withstand anoxic environments during overwintering
Authors: Lari Ebrahim , Buck Leslie T. 
Published: September 2021

ABSTRACT
In most vertebrates, anoxia drastically reduces the production of the essential adenosine triphosphate (ATP) to power its many necessary functions, and, consequently, cell death occurs within minutes. However, some vertebrates, such as the painted turtle (Chrysemys picta bellii), have evolved the ability to survive months without oxygen by simultaneously decreasing ATP supply and demand, surviving the anoxic period without any apparent cellular damage. The impact of anoxia on the metabolic function of painted turtles has received a lot of attention. However, the impact of low temperature has received less attention and the interactive effect of anoxia and temperature even less. In the present study, we investigated the interactive impacts of reduced temperature and severe hypoxia on the electrophysiological properties of pyramidal neurons in painted turtle cerebral cortex. Our results show that an acute reduction in temperature from 20 to 5°C decreases membrane potential, action potential width and amplitude, and whole-cell conductance. Importantly, acute exposure to 5°C considerably slows membrane repolarization by voltage-gated K+ channels. Exposing pyramidal cells to severe hypoxia in addition to an acute temperature change slightly depolarized membrane potential but did not alter action potential amplitude or width and whole-cell conductance. These results suggest that acclimation to low temperatures, preceding severe environmental hypoxia, induces cellular responses in pyramidal neurons that facilitate survival under low oxygen concentrations. In particular, our results show that temperature acclimation invokes a change in voltage-gated K+ channel kinetics that overcomes the acute inhibition of the channel.
Membrane lipid metabolism, heat shock response and energy costs mediate the interaction between acclimatization and heat-hardening response in the razor clam Sinonovacula constricta
Authors: Zhang Wenyi , Dong Yunwei 
Published: September 2021

ABSTRACT
Thermal plasticity on different time scales, including acclimation/acclimatization and heat-hardening response – a rapid adjustment for thermal tolerance after non-lethal thermal stress, can interact to improve the resilience of organisms to thermal stress. However, little is known about physiological mechanisms mediating this interaction. To investigate the underpinnings of heat-hardening responses after acclimatization in warm seasons, we measured thermal tolerance plasticity, and compared transcriptomic and metabolomic changes after heat hardening at 33 or 37°C followed by recovery of 3 or 24 h in an intertidal bivalve Sinonovacula constricta. Clams showed explicit heat-hardening responses after acclimatization in a warm season. The higher inducing temperature (37°C) caused less effective heat-hardening effects than the inducing temperature that was closer to the seasonal maximum temperature (33°C). Metabolomic analysis highlighted the elevated content of glycerophospholipids in all heat-hardened clams, which may help to maintain the structure and function of the membrane. Heat shock proteins (HSPs) tended to be upregulated after heat hardening at 37°C but not at 33°C, indicating that there was no complete dependency of heat-hardening effects on upregulated HSPs. Enhanced energy metabolism and decreased energy reserves were observed after heat hardening at 37°C, suggesting more energy costs during exposure to a higher inducing temperature, which may restrict heat-hardening effects. These results highlight the mediating role of membrane lipid metabolism, heat shock responses and energy costs in the interaction between heat-hardening response and seasonal acclimatization, and contribute to the mechanistic understanding of evolutionary change and thermal plasticity during global climate change.
ACSM Expert Consensus Statement on Exertional Heat Illness: Recognition, Management, and Return to Activity
Authors: Roberts William O. , Armstrong Lawrence E. , Sawka Michael N. , Yeargin Susan W. , Heled Yuval , O’Connor Francis G. 
Published: September 2021

Abstract
Exertional heat stroke (EHS) is a true medical emergency with potential for organ injury and death. This consensus statement emphasizes that optimal exertional heat illness management is promoted by a synchronized chain of survival that promotes rapid recognition and management, as well as communication between care teams. Health care providers should be confident in the definitions, etiologies, and nuances of exertional heat exhaustion, exertional heat injury, and EHS. Identifying the athlete with suspected EHS early in the course, stopping activity (body heat generation), and providing rapid total body cooling are essential for survival, and like any critical life-threatening situation (cardiac arrest, brain stroke, sepsis), time is tissue. Recovery from EHS is variable, and outcomes are likely related to the duration of severe hyperthermia. Most exertional heat illnesses can be prevented with the recognition and modification of well-described risk factors ideally addressed through leadership, policy, and on-site health care.
Low-Energy Availability and the Electronic Preparticipation Examination in College Athletes: Is There a Better Way to Screen?
Authors: Goldstein Rachel , Carlson Jennifer , Tenforde Adam , Golden Neville , Fredericson Michael 
Published: September 2021

Abstract
The electronic preparticipation physical examination (ePPE) is commonly used to identify health conditions that would affect participation in sports for athletes, including disordered eating and/or low energy availability (EA). A secondary analysis was performed using a cohort study of female college athletes attending a Division 1 university between 2008 and 2014. Descriptive statistics and logistic regression analyses were used to explore the association between responses to questions on the ePPE related to eating behaviors and Female Athlete Triad (Triad). Risk categories (low, moderate, or high) were assigned to 239 athletes participating in 16 sports. The majority of responses on the ePPE did not identify athletes associated with moderate-/high-risk categories. Our findings suggest that ePPE may not sufficiently identify athletes at elevated risk for health concerns of the Triad. Our findings suggest that future ePPE may consider validated screening tools for disordered eating to help identify athletes at risk of low EA.
Achilles Tendinopathy, A Brief Review and Update of Current Literature
Authors: Vo Thuy Phuong , Ho Garry W. K. , Andrea John 
Published: September 2021

Abstract
Chronic pain in the Achilles tendon is a common problem in both athletes and nonathletes alike. The etiology for the development of Achilles tendinopathy has not been fully elucidated, and there remains multiple theories to explain the pain and dysfunction accompanying this condition. The diagnosis of Achilles tendon problems continues to rely on the clinical history and physical examination. The optimal management of pain, restoration of function, and return-to-sports participation with Achilles tendinopathy are evolving because of the advancement in technologies and research regarding its pathophysiology. This article aims to provide a brief review of the relevant anatomy, differential diagnosis, imaging findings, and an update of the literature on conservative and minimally invasive managements of chronic Achilles tendinopathy.
Training strategies to minimize interchannel interference effects using supervised learning in gridless Nyquist-WDM systems
Authors: Escobar Pérez Alejandro , Zabala-Blanco David , Azurdia Meza Cesar A. , Guerrero González Neil , Granada Torres Jhon J. 
Published: September 2021

The dynamism envisioned in future high-capacity gridless optical networks requires facing several challenges in distortion mitigation, such as the mitigation of interchannel interference (ICI) effects in any optical channel without information of their adjacent channels. Machine learning (ML)-based techniques have been proposed in recent works to estimate and mitigate different optical impairments with promising results. We propose and evaluate two training strategies for supervised learning algorithms with the aim to minimize ICI effects in a gridless

3

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-Gbaud 16-quadrature amplitude modulation (QAM) Nyquist-wavelength-division multiplexing (WDM) system. One strategy, called updating strategy, is based on symbol training sequence, and the other one, called characterization strategy, is based on an offline training using a previous system characterization. Artificial neural networks (ANN), support vector machine (SVM), K-nearest neighbors (KNN), and extreme learning machine (ELM) algorithms are explored for both training strategies. Experimental results showed a bit error rate (BER) improvement at low training lengths for both training strategies, for instance, gains up to

∼

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d
B

in terms of optical signal-to-noise ratio were achieved in a back-to-back scenario. Besides, the KNN and ELM algorithms showed significant BER reduction in transmission over 250 km optical fiber. Additionally, we carried out a brief computational complexity analysis where ELM presented only 1.9% of ANN processing time. Hence, the use of ML-based techniques could enhance the optical gridless networks performance and consequently fulfill future traffic demands.
Underwater imaging in optical turbulence: average temperature and salinity effects
Authors: Ata Yalçın , Korotkova Olga 
Published: September 2021

Classic imaging systems may experience deleterious effects of optical turbulence, leading to their quality degradation induced by image jitter and blur. Using a recently introduced model for the refractive index power spectrum of natural water turbulence accounting for average temperature in the range of 0°–30°C and average salinity concentration in NaCl in the range of 0–40 ppt, we derive expressions for turbulence-induced modulation transfer functions. Our analysis indicates that the imaging systems are very sensitive not only to the variance of fluctuations in these parameters but also to their average values. Our results are essential for underwater optical engineering, providing regional and seasonal variations in optical turbulence.
The role of urbanisation in the spread of Aedes mosquitoes and the diseases they transmit—A systematic review
Authors: Kolimenakis Antonios , Heinz Sabine , Wilson Michael Lowery , Winkler Volker , Yakob Laith , Michaelakis Antonios , Papachristos Dimitrios , Richardson Clive , Horstick Olaf 
Published: September 2021

Background
This systematic review aims to assess how different urbanisation patterns related to rapid urban growth, unplanned expansion, and human population density affect the establishment and distribution of Aedes aegypti and Aedes albopictus and create favourable conditions for the spread of dengue, chikungunya, and Zika viruses.

Methods and findings
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review was conducted using the PubMed, Virtual Health Library, Cochrane, WHO Library Database (WHOLIS), Google Scholar, and and the Institutional Repository for Information Sharing (IRIS) databases. From a total of 523 identified studies, 86 were selected for further analysis, and 29 were finally analysed after applying all inclusion and exclusion criteria. The main explanatory variables used to associate urbanisation with epidemiological/entomological outcomes were the following: human population density, urban growth, artificial geographical space, urban construction, and urban density. Associated with the lack of a global definition of urbanisation, several studies provided their own definitions, which represents one of the study’s limitations. Results were based on 8 ecological studies/models, 8 entomological surveillance studies, 7 epidemiological surveillance studies, and 6 studies consisting of spatial and predictive models. According to their focus, studies were categorised into 2 main subgroups, namely “Aedes ecology” and “transmission dynamics.” There was a consistent association between urbanisation and the distribution and density of Aedes mosquitoes in 14 of the studies and a strong relationship between vector abundance and disease transmission in 18 studies. Human population density of more than 1,000 inhabitants per square kilometer was associated with increased levels of arboviral diseases in 15 of the studies.

Conclusions
The use of different methods in the included studies highlights the interplay of multiple factors linking urbanisation with ecological, entomological, and epidemiological parameters and the need to consider a variety of these factors for designing effective public health approaches.
The association between tropical cyclones and dengue fever in the Pearl River Delta, China during 2013-2018: A time-stratified case-crossover study
Authors: Li Chuanxi , Zhao Qi , Zhao Zhe , Liu Qiyong , Ma Wei 
Published: September 2021

Background
Studies have shown that tropical cyclones are associated with several infectious diseases, while very few evidence has demonstrated the relationship between tropical cyclones and dengue fever. This study aimed to examine the potential impact of tropical cyclones on dengue fever incidence in the Pearl River Delta, China.

Methods
Data on daily dengue fever incidence, occurrence of tropical cyclones and meteorological factors were collected between June and October, 2013–2018 from nine cities in the Pearl River Delta. Multicollinearity of meteorological variables was examined via Spearman correlation, variables with strong correlation (r>0.7) were not included in the model simultaneously. A time-stratified case-crossover design combined with conditional Poisson regression model was performed to evaluate the association between tropical cyclones and dengue fever incidence. Stratified analyses were performed by intensity grades of tropical cyclones (tropical storm and typhoon), sex (male and female) and age-groups (<18, 18–59, ≥60 years).

Results
During the study period, 20 tropical cyclones occurred and 47,784 dengue fever cases were reported. Tropical cyclones were associated with an increased risk of dengue fever in the Pearl River Delta region, with the largest relative risk of 1.62 with the 95% confidence interval (1.45–1.80) occurring on the lag 5 day. The strength of association was greater and lasted longer for typhoon than for tropical storm. There was no difference in effect estimates between males and females. However, individuals aged over 60 years were more vulnerable than others.

Conclusions
Tropical cyclones are associated with increased risk of local dengue fever incidence in south China, with the elderly more vulnerable than other population subgroups. Health protective strategies should be developed to reduce the potential risk of dengue epidemic after tropical cyclones.
Unconditioned and learned morphine tolerance influence hippocampal-dependent short-term memory and the subjacent expression of GABA-A receptor alpha subunits
Authors: Ghamkharinejad Ghazaleh , Marashi Seyed Hossein , Foolad Forough , Javan Mohammad , Fathollahi Yaghoub 
Published: September 2021

Background
ɣ-aminobutyric acid (GABA) facilitator valproic acid may be able to curb memory disruption induced by morphine exposure.

Objective
The effects of the GABA facilitator valproic acid on the behavioral tolerance induced by morphine were investigated. Then hippocampal-dependent tasks named spatial-working and short-term memory procedures using the Y-maze apparatus were examined in morphine tolerant rats. Finally, the changes in the expression of hippocampal GABA-A receptors underlying morphine tolerance were also examined.

Methods
Rats were treated with daily morphine injections, with or without distinct contextual pairing. To examine the effect of valproic acid on morphine tolerance expression, valproic acid was pretreated an hour before morphine. Spatial-working and short-term memory procedures using the Y-maze apparatus were examined in morphine tolerant rats. Afterwards the changes in the expression of hippocampal GABAα receptors using the quantitative real-time PCR and western blot techniques to detect GABArα subunits mRNAs and protein level were studied.

Results
Our results showed that both learned and non-associative morphine tolerance influence short-term memory and the subjacent expression of GABArα mRNAs and protein level. Despite its attenuating effects on the development and expression of both learned and non-associative morphine tolerance, only associative morphine tolerance-induced memory dysfunction was ameliorated by valproic acid pretreatment. We also found that the expression of GABArα1, α2, α5 subunits mRNAs and GABAα protein level were affected heavier in associative morphine tolerant rats.

Conclusion
Our data supports the hypothesis that unconditioned and learned morphine tolerance influences short-term memory and the expression of GABArα 1, α2, α5 mRNAs and GABArα protein level differently, and adds to our understanding of the behavioral and molecular aspects of the learned tolerance to morphine effects.
How do befriending interventions alleviate loneliness and social isolation among older people? A realist evaluation study
Authors: Fakoya Olujoke A. , McCorry Noleen K. , Donnelly Michael 
Published: September 2021

Background
Befriending is a popular way in which to intervene to combat loneliness and social isolation among older people. However, there is a need to improve our understanding about how these interventions work, for whom and in which contexts, to make the best use of the increasing investment in the provision and delivery of befriending services.

Methods
A realist evaluation was undertaken as it focuses on uncovering causal processes and interactions between mechanisms and contextual characteristics. Five case studies of befriending programmes in Northern Ireland were studied, reflecting variation in contextual variables, service user and provider characteristics. Data was collected via service documentation and semi-structured interviews (n = 46) with stakeholders involved in the delivery and receipt of befriending interventions.

Results
Eight initial programme theories were generated, which were ‘tested’ in the case study analysis to uncover context-mechanism-outcome relationships. Mechanisms identified included reciprocity, empathy, autonomy, and privacy which were triggered in different contexts to support the alleviation of loneliness and social isolation. Reciprocity was ‘triggered’ in contexts where service users and befrienders shared characteristics, the befriender was a volunteer and befriending took the form of physical companionship. Contexts characterised in terms of shared experiences between befriender and service user triggered empathy. Autonomy was triggered in contexts where befriending relationships were delivered long-term and did not focus on a pre-defined set of priorities. Privacy was triggered in contexts where service users had a cognitive/sensory impairment and received one-to-one delivery.

Conclusion
This study improves understanding about how and why befriending interventions work. Findings indicate that services should be tailored to the needs of service users and take into consideration characteristics including mobility, impairments e.g. physical, sensory and/or cognitive, as well as the influence of service characteristics including payment for befrienders, fixed/long-term befriending relationship, one-to-one support and the impact of non-verbal communication via face-to-face delivery.