bluuebunny/crossref_metadata_2025_split huggingface dataset:
Administration of Parenteral Vitamin C in Patients With Severe Infection: Protocol for a Systematic Review and Meta-analysis
Authors: Agarwal Arnav , Basmaji John , Fernando Shannon M , Ge Fang Zhou , Xiao Yingqi , Faisal Haseeb , Honarmand Kimia , Hylands Mathieu , Lau Vincent I , Lewis Kimberley , Couban Rachel , Lamontagne François , Adhikari Neill KJ 
Published: December 2021

Background
Severe infections are characterized by inflammation and oxidative damage. Ascorbic acid (vitamin C) administration may attenuate oxidative damage and, in turn, reduce vascular endothelial injury in pulmonary and systemic vasculature.

Objective
We aim to describe a protocol for a living systematic review that will evaluate the effectiveness and safety of parenteral vitamin C administration in adults with severe infections, including those with COVID-19.

Methods
We searched Ovid MEDLINE, Embase, CINAHL, the Centers for Disease Control and Prevention COVID-19 database, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov from inception to March 30, 2021, for randomized controlled trials evaluating parenteral vitamin C versus no parenteral vitamin C in hospitalized adults with severe infection. Eligible studies will include at least 1 arm involving any dose of parenteral vitamin C alone or in combination with other cointerventions and at least 1 arm not involving parenteral vitamin C. The primary outcomes of interest will include in-hospital, 30-day, and 90-day mortality. Title and abstract screening, full-text screening, data extraction, and risk of bias evaluation via a modified Risk of Bias 2.0 tool will be conducted independently and in pairs. We will perform random effects modeling for meta-analyses, in which study weights will be generated by using the inverse variance method. We will assess certainty in effect estimates by using the Grading of Recommendations Assessment, Development and Evaluation methodology. Meta-analyses will be updated iteratively as new trial evidence becomes available.

Results
Among the 1386 citations identified as of March 30, 2021, a total of 17 eligible randomized controlled trials have been identified as of September 2021. We are in the process of updating the search strategy and associated data analyses.

Conclusions
The results will be of importance to critical care physicians and hospitalists who manage severe infection and COVID-19 in daily practice, and they may directly inform international clinical guidance. Although our systematic review will incorporate the most recent trial evidence, ongoing trials may change our confidence in the estimates of effects, thereby necessitating iterative updates in the form of a living review.

Trial Registration
PROSPERO CRD42020209187; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=209187

International Registered Report Identifier (IRRID)
RR1-10.2196/33989
Tính chất điện tử của dãy nano penta-graphene biên răng cưa sai hỏng dạng khuyết
Authors: Nguyễn Thành Tiên , Lê Võ Phương Thuận , Đào Hoàng Chương , Võ Thị Ngọc Huyền 
Published: December 2021

Trong bài báo này, tính chất điện tử của các dãy penta-graphene dạng răng cưa (SSPGNR) sai hỏng dạng khuyết (DSSPGNRs) được nghiên cứu bằng cách tính năng lượng liên kết, cấu trúc vùng điện tử và mật độ trạng thái bởi phương pháp nguyên lý ban đầu. Ba kiểu khuyết được khảo sát trong nghiên cứu này là khuyết đơn nguyên tử C1, C2 và khuyết đồng thời hai nguyên tử C2. Kết quả nghiên cứu cho thấy DSSPGNR có độ rộng vùng cấm giảm đáng kể so với mẫu không khuyết. Trong đó, DSSPGNRs khuyết đồng thời hai nguyên tử C2 có độ rộng vùng cấm giảm nhiều hơn so với DSSPGNRs khuyết đơn nguyên tử. Kết quả nghiên cứu này cung cấp thông tin quan trọng cho việc phát triển ứng dụng penta-graphene trong lĩnh vực vi điện tử.
El proyecto arquitectónico de la filosofía crítica de Kant como reforma a la filosofía
Authors: Caballero López Daniel 
Published: December 2021

El presente artículo ofrece una interpretación de la totalidad de la filosofía kantiana como reforma al concepto de filosofía de acuerdo con la naturaleza metafísica y moral de la razón. Para ello se articulan los elementos que sirven a la reforma, a saber, la comprensión de la filosofía bajo el concepto escolástico y bajo el cósmico, este último desprendido de la teleología racional expresada en la consideración histórica de la filosofía. Después, se construye la interpretación de la metodología arquitectónica que utiliza la reforma, primero demostrando que la pregunta crítica sobre los juicios sintéticos a priori sirve para determinar los conocimientos posibles; posteriormente, argumentando que la pregunta se subsume a los intereses racionales de los seres humanos para vincular los conocimientos con el fin de la razón, lo cual corresponde a la estructuración de la filosofía según la Sabiduría a la que tiende. Por último, se propone cuál es la labor que cada Crítica tiene dentro de todo el proyecto de reforma. La interpretación, por tanto, recupera las intenciones eminentemente metafísicas y morales de la empresa kantiana, permitiendo abordarla en su conjunto.
Pengabdian Integratif: Revitalisasi Situs Kabuyutan Ciburuy Sebagai Desa Wisata Budaya dan Pusat Ekonomi Kreatif
Authors: Alim Muhamad 
Published: December 2021

Pengabdian pada masyarakat pada dasarnya merupakan aktivitas wajib bagi akademisi di setiap perguruan tinggi karena tercantum dalam Tri Dharma Perguruan Tinggi. Tidak terkecuali lembaga eksekutif mahasiswa yang menghimpun dan memberdayakan mahasiswa untuk mengimplementasikan ilmunya bagi masayarakat. Pengabdian yang memadukan antara potensi budaya lokal dengan kebutuhan masyarakat dinilai mampu mengatasi permasalahan ekonomi dan sosial. Pengabdian ini dimulai pada bulan Juni 2019 dan akan terus diupayakan keberlanjutannya hingga menjadikan desa Pamalayan yang terletak secara strategis di kaki gunung Cikuray kabupaten Garut sebagai desa wisata budaya dan pusat ekonomi kreatif. Dampaknya, masayarakat dapat secara mandiri mengembangkan ekonominya dan melestarikan kebudayaan lokal. Metode yang digunakan adalah pengabdian kolaboratif dengan pemerintah, pengusaha lokal dan komunitas, pelatihan partisipatif, diskusi kenaskahan dan pemberdayaan ekonomi kreatif. Pengabdian berbasis budaya ini juga menggunakan pendekatan seni, teknologi dan sains dalam implementasinya. Pengabdian ini terbukti turut berperan dalam pelestarian kebudayaan sunda, seperti naskah kuno kesundaan, tari Jaipong dan pancak silat yang akan meningkatkan daya tarik wisatawan. Pengabdian juga berpengaruh dalam meningkatkan taraf hidup mayarakat desa Pamalayan melalui media ekonomi kreatif berbasis kearifan lokal. Pengabdian ini sangat penting dilakukan untuk memajukan kebudayaan lokal dan meningkatkan pendidikan serta ekonomi masyarakat desa.
Pengenalan Beretika Komunikasi dalam Sosial Media di Kalangan Remaja SMA Windu Wacana Kota Cirebon
Authors: Siraj Nurudin , Nurfalah Farida , Listiana Raden Annisa , Santika Rifka Noviani 
Published: December 2021

Pertumbuhan penggunaan internet dari tahun ke tahun selalu meningkat di berbagai media terutama di media online. SMA Windu wacana sangar peduli pada pendidkan seringkali memposting dan memotivasi siswanya untuk peduli pendidikan terlebih lagi literasi media. Sebagai tindakan prepentif bagi Siswa mengenai nilai dan etika berkomunikasi untuk menjaga nama baik dan almamaternya dengan melakukan ceramah melakukan pengenalan, evaluasi dan studi kasus dalam postingan mereka di media sosial. Remaja SMA Windu Wacana sebagai peserta mereka mengatakan bahwa mereka menjadi lebih mengetahui tentang komunikasi, lebih mengetahui tata cara berkomunikasi dan lebih bijak menggunakan komunikasi karena seperti pada materi sosialisasi bahwa banyak informasi berada di media digital membuat seseorang sulit menentukan informasi yang benar dan tidak benar serta upload informasi maupun foto harus bagus dan baik dan menjaga sopan santun. Peserta sosialisasi bertambah pengetahuannya dan dapat menyimak serta menjelaskan kembali bahkan mampu menganalisis dan memaknai tentang materi yang disampaikan. Literasi media sosial diantara mereka sudah mulai tertatam berdasarkan wawasan dan pengalaman yang mereka alami. Mereka memiliki kesadaran dan ikut berupaya dalam melakukan etika komunikasi di media sosial dengan mendeskripsikan upaya dan cara yang harus mereka lakukan. Mereka menggunakan media sosial untuk kebutuhan akan informasi, wawasan serta mereka dalam mengposting informasi dan gambar dipertimbangkan dari aspek etika dan nilai manfaatnya, bahkan mereka menerima saran untuk mengikuti Akun yang ada kaitannya dengan hobby, promosi dan lainnya sehingga mereka dapat menjadi rujukan untuk beretika komunikasi dalam menggunakan media sosial karena semua siswa dan guru yang mengikuti sosialisasi memiliki media sosial dan peningkatan keberdayaan mitra sesuai permasalahan yang dihadapi
Detección de Pasteurella multocida, Mannhemia haemolytica, Histophilus somni y Mycoplasma bovis en pulmón de bovinos
Authors: Cengiz Seyda , Adıgüzel M. Cemal , Dinç Gökçen 
Published: December 2021

In this study, it was aimed to determine of P. multocida, M. haemolytica, H. somni and M. bovis in macroscopically healthy cattle lungs by PCR. The study was carried out on 82 macroscopically healthy cattle lung. DNA extraction was performed to the lung samples. PCR was then performed using all specific primers. By molecular evaluation, positive results were achieved for P. multocida, M. haemolytica, H. somni and M. bovis in 4 (4.8 %), 4 (4.8 %), 6 (7.3 %) and 3 (3.6 %) of the samples, respectively. Mix infections were detected in five samples. Of the samples, two were positive for both P. multocida and M. haemolytica, two were positive for both M. haemolytica and H. somni and one was positive for both P. multocida and H. somni. However, a positive sample, which carried all of pathogens, was not detected. In conclusion, P. multocida, M. haemolytica, H. somni and M. bovis are the important opportunistic pathogens of respiratory tract in cattle and these pathogens have a major role during infections. But multifactorial nature of bovine respiratory disease and immune system affected the formation of the disease. Hence, firstly cattle’s immunity should be strengthened and other conditions should be kept under control.
Los artefactos tecnológicos y su relación con la ciencia, la tecnología, la sociedad, el medio ambiente y su aporte a la empresa
Authors: Cárdenas Salgado Enrique Diógenes 
Published: December 2021

El presente artículo es producto del trabajo de investiga- ción que se desarrolló en el marco del doctorado Interinsti- tucional en Educación, tiene como objetivo, contribuir a la búsqueda de la relación de los artefactos tecnológicos con la ciencia, la tecnología, la sociedad, el medio ambiente y su aporte a la empresa.
Los hallazgos buscan a partir de la pregunta: ¿Es posible hacer arqueología a los artefactos tecnológicos para develar las relaciones que éste tiene con la ciencia, la tecnología, la sociedad, el medio ambiente y la empresa, generar una estrategia para el aprendizaje de la tecnología y la alfabeti- zación del talento humano? La hipótesis de trabajo sobre esta pregunta es afirmativa y se propone que los artefactos siendo el resultado de un proceso tecnológico y social pue- den revelar dichas relaciones de conceptos. A partir de este supuesto, el discurso juega un papel decisivo en la cualifi- cación de los sujetos. La metodología utilizada, permitirá establecer que los aportes de la Teoría del Discurso ayuden a organizar un método arqueológico para observar los ar- tefactos tecnológicos o más concretamente lo que puede hacer la hermenéutica como método.
Valoración de Empresa Transportadora en el Meta: Estudio de Caso
Authors: Pérez D Kelly Melissa , Romero H Yesica Paola 
Published: December 2021

El crecimiento de la economía ha sido el detonante de mu- chos cambios a nivel estructural y financiero de las empre- sas, en donde la búsqueda de creación de valor por parte de estas se convirtió en un objetivo principal y gracias a ello se le asignó un papel fundamental al área financiera dentro de las empresas siendo que “las finanzas buscaron la creación de valor, poniendo en funcionamiento nuevos esquemas de inversión, el apalancamiento financiero y operativo” (Crive- llini, 2010, párr.3).
Por tal motivo se llega a la necesidad de la realización de la valoración por lo cual es necesario recurrir al histórico de tres años de Estados de Situación Financiera, que a su vez permitirá determinar la situación real de liquidez y los resul- tados operacionales de esta entidad, para aplicar el método de flujo de caja libre descontado, apto para empresas que no cotizan en bolsa y con el que se puede conocer la situación actual, si esta es favorable para exhibir ante inversionistas, futuros socios o compradores y si la gestión fue óptima.
Contribución del software para el área contable y financiera en las Pymes del sector educativo
Authors: Baquero Cortes Fernando , Ramos Rodríguez Angy P. , Riscanevo Diaz Gineth K. 
Published: December 2021

A comienzos de los años ochenta con el auge de los computadores surgieron múltiples soluciones informáticas para la contabilidad, lo que influyó en gran medida en el desarrollo de los softwares contables, esto ha producido que tanto las grandes como las pequeñas y medianas entidades utilicen las TIC, por tal motivo el alcance de esta investigación se fundamenta en determinar la contribución del software en el área contable y financiera del sector educación, particularmente colegios privados de la básica primaria y secundaria del municipio de Villavicencio, año 2020.
Para los efectos de la investigación como instrumentos de recolección de información se utiliza una ficha de caracterización, encuestas y entrevistas semiestructuradas aplicadas a la unidad de análisis seleccionada.
Management of a Patient With Tracheal Stenosis After Previous Tracheotomy
Authors: Takaishi Kazumi , Kawahito Shinji , Kitahata Hiroshi 
Published: December 2021

Tracheal stenosis after tracheotomy can cause difficult airway management and respiratory complications. It is difficult to predict tracheal stenosis after tracheotomy based on a patient's symptoms as the symptoms of tracheal stenosis appear only after they become severe. In patients with a history of previous tracheotomy, it is important to consider the risk factors for tracheal stenosis. Detailed preoperative evaluation of patients with a history of previous tracheotomy is essential and should include 3-dimensional assessment of the airway.
We report the preoperative assessment and perioperative management of an 83-year-old woman at high risk for tracheal stenosis due to a previous emergency tracheotomy who was scheduled to undergo general anesthesia for a right maxillectomy for squamous cell carcinoma. Preoperative anteroposterior chest radiograph revealed findings indicative of tracheal stenosis. Additional detailed examinations of the stenotic area were conducted with computed tomography imaging and bronchofiberscopy. General anesthesia with nasotracheal intubation was performed, and although there were no adverse intraoperative events, stridor after extubation was observed. Nebulized epinephrine was administered via an ultrasound nebulizer and effectively improved the patient's postoperative transient dyspnea.
Airway Complications in Intubated Versus Laryngeal Mask Airway–Managed Dentistry: A Meta-Analysis
Authors: Prince Jordan , Goertzen Cameron , Zanjir Maryam , Wong Michelle , Azarpazhooh Amir 
Published: December 2021

Objective:
Serious airway complications can occur with inadequate airway management during general anesthesia (GA). This meta-analysis investigated randomized controlled trials that compared perioperative technique failures and airway complications, including hypoxia, during GA for dentistry using endotracheal intubation or a laryngeal mask airway (LMA) for airway management.

Methods:
A systematic search of electronic databases and gray literature was completed. Independent reviewers assessed eligibility, performed data extraction, completed risk of bias assessment, and judged the quality of results through Grading of Recommendations, Assessment, Development, and Evaluation. Risk ratios (RRs) for airway complications, with 95% CIs, were calculated. Heterogeneity was quantified using the I2 statistic. Sensitivity and age-subgroup analyses were explored.

Results:
Six trials were deemed eligible from a total of 9076 identified reports. The airway management intervention for these trials was LMA. Technique failures or effect differences in airway complications were not detected except for postoperative hypoxia, where LMA use had a decreased risk (RR, 0.22; 95% CI, 0.06-0.77; I2 = 0%; moderate quality). A similar effect was seen in the pediatric analysis (RR, 0.10; 95% CI, 0.01-0.84; I2 = 0%; moderate quality). Additionally, LMA use reduced pediatric sore throat risk (RR, 0.08; 95% CI, 0.04-0.15; I2 = 0%; moderate quality).

Conclusion:
Use of an LMA in dentistry may have the potential to reduce the risk of postoperative hypoxia, particularly in pediatric patients, although further study is required.
Programmes et interventions favorisant l’équité en santé dans les populations LGBTQ2+ au Canada par des mesures sur les déterminants sociaux de la santé
Authors: Higgins Robert , Hansen Brian , Jackson Beth E. , Shaw Ashley , Lachowsky Nathan J. 
Published: December 2021

Résumé

Les minorités sexuelles et de genre vivent un certain nombre d’inégalités en matière de santé. On sait que les déterminants sociaux de la santé sont à l’origine de ces iniquités, mais on dispose de peu de données probantes sur le nombre et les types d’interventions au Canada qui portent sur ces déterminants pour ces populations. Nous avons effectué une analyse des programmes disponibles au Canada qui ciblent les minorités sexuelles et de genre et nous les avons classés en fonction de leur niveau d’intervention (individuel/interpersonnel, institutionnel et structurel). Nous avons constaté que peu de programmes ciblent les femmes, les adultes en milieu de vie, les Autochtones ou les minorités ethnoraciales, les immigrants et les réfugiés récents ou encore les locuteurs de langues minoritaires, et que peu d’interventions se déroulent à un niveau structurel.
Force performance of trawl system – III: mathematical modeling (part I)
Authors: Nedostup Aleksandr , Razhev Alexey Olegovich , Nasenkov Pavel , Konovalova Karina , Bykov Alexey Aleksandrovich , Pivovarova Yulia Sergeevna 
Published: December 2021

The force performance of trawl systems directly depends on the work performed by these forces.The mechanical work of a trawl system is a physical quantity that depends on the vectors of force (hydrodynamic, tension, compression, etc.) and displacement. Thermodynamic work is the amount of energy transmitted or received by the trawl system by changing its external parameters. There is also the work of the forces of the electrostatic field when the charge moves from one point of the field to another. Equations are obtained for ideal flexible steel ropes and rope-rope products, characterizing the direct proportionality of the ratio of the productivity of forces that are directed perpendicular to each other and depend on the Poisson's ratio and the constructive elongation of ideal flexible steel ropes and cordage products. The ratio of the capacities of the forces or the ratio of the moduli of elasticity in the transverse and longitudinal directions, which arise when steel ropes and rope-rope products are stretched, are inversely proportional to the square of the coefficient k connecting the elongation λ, Poisson's ratio μ and the relative elongation ε at a constant volume of the product and its mass. There has been described an example of stretching perfectly flexible steel
ropes and cordage. Such constructive parameters as lay, the number of strands, wire and fiber thickness, type of weaving were not taken into account.
Early prognostic stratification and identification of irreversibly shocked patients despite primary percutaneous coronary intervention
Authors: Falco Luca , Fabris Enrico , Gregorio Caterina , Pezzato Andrea , Milo Marco , Massa Laura , Lardieri Gerardina , Korcova Renata , Cominotto Franco , Vitrella Giancarlo , Rakar Serena , Perkan Andrea , Sinagra Gianfranco 
Published: December 2021

Background
Despite prognostic improvements in ST-elevation myocardial infarction (STEMI), patients presenting with cardiogenic shock (CS) have still high mortality. Which are the relevant early prognostic factors despite revascularization in this high-risk population is poorly investigated.

Methods
We analyzed STEMI patients treated with primary percutaneous coronary intervention (PCI) and enrolled at the University Hospital of Trieste between 2012 and 2018. A decision tree based on data available at first medical contact (FMC) was built to stratify patients for 30-day mortality. Multivariate analysis was used to explore independent factors associated with 30-day mortality.

Results
Among 1222 STEMI patients consecutively enrolled, 7.5% presented with CS. CS compared with no-CS patients had worse 30-day mortality (33% vs 3%, P < 0.01). Considering data available at FMC, CS patients with a combination of age ≥76 years, anterior STEMI and an expected ischemia time > 3 h and 21 min were at the highest mortality risk, with a 30-day mortality of 85.7%. In CS, age (OR 1.246; 95% CI 1.045–1,141; P = 0.003), final TIMI flow 2–3 (OR 0.058; 95% CI 0.004–0.785; P = 0.032) and Ischemia Time (OR = 1.269; 95% CI 1.001–1.609; P = 0.049) were independently associated with 30-day mortality.

Conclusions
In a contemporary real-world population presenting with CS due to STEMI, age is a relevant negative factor whereas an early and successful PCI is positively correlated with survival. However, a subgroup of elderly patients had severe prognosis despite revascularization. Whether pPCI may have an impact on survival in a very limited number of irreversibly critically ill patients remains uncertain and the identification of irreversibly shocked patients remains nowadays challenging.
Ultrasound-guided placement of an anchor wire or injection of methylene blue to aid in the intraoperative localization and excision of peripheral lymph nodes in dogs and cats
Authors: Rossanese Matteo , Pierini Alessio , Pisani Guido , Freeman Alistair , Burrow Rachel , Booth Malcolm , Marchetti Veronica , Finotello Riccardo 
Published: December 2021

Abstract

OBJECTIVE
To evaluate ultrasound-guided placement of an anchor wire (AW) or injection of methylene blue (MB) to aid in the intraoperative localization of peripheral lymph nodes in dogs and cats.

ANIMALS
125 dogs and 10 cats with a total of 171 lymphadenectomies.

PROCEDURES
Medical records of dogs and cats that underwent peripheral lymphadenectomies with or without (N) the AW or MB localization technique were reviewed. Data retrieved included clinical, surgical, and histologic findings. The proportions of successful lymphadenectomies, lymph node characteristics, and complications among the 3 groups were analyzed.

RESULTS
143 (84%) lymph nodes were successfully excised. Lymphadenectomy success was significantly affected by the localization technique, with 94% for group AW, 87% for group MB, and 72% for group N. Lymph node size was smaller in groups AW and MB, compared with group N. Duration of lymphadenectomy was shorter in group AW, compared with groups MB and N, and in group MB, compared with group N. Intra- (7%) and postoperative (10%) complications and final diagnosis did not significantly differ among groups.

CONCLUSIONS AND CLINICAL RELEVANCE
Both lymph node localization techniques were highly successful and reduced surgery time, compared with unassisted lymphadenectomy. Specifically, these techniques were effective for localization of normal-sized and nonpalpable lymph nodes and were efficient and practical options for peripheral lymphadenectomies, particularly for those that were small or nonpalpable.