bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of COVID-19 on the Japanese healthcare system and comparison of its mitigation measures with South Korea and Taiwan
Authors: Shin Jung-ho , Lin Huei-Ru , Imanaka Yuichi 
Published: July 2021

Abstract
Since the coronavirus disease 2019 (COVID-19) pandemic has begun, Asian countries/regions, such as Japan, South Korea, and Taiwan, had generally controlled the pandemic better than other countries. In this article, we showed the big impact of the pandemic on acute care hospitals in Japan, where the number of COVID-19 patients has been smaller than in other countries. We also compared the mitigation measures against the COVID-19 pandemic among Japan, South Korea, and Taiwan to study the factors affecting the differences among these relatively well-controlled countries/regions. We analyzed Diagnosis Procedure Combination data from the Quality Indicator/Improvement Project database, in which Japanese hospitals participated voluntarily. During the first declaration of emergency, which was from April 4 to May 25, the numbers of inpatients decreased roughly 20% for adults and 40% for those aged under 18 years compared to those of the same period in the previous year. In the analyses by disease, hospitalizations with acute coronary syndrome, ischemic stroke, cancer, childhood non-COVID-19 acute infections, infant and pediatric asthma decreased in number, whereas those with alcohol-related liver diseases and pancreatitis increased. Comparing selected mitigation measures against COVID-19, such as border control, enforced measures, information governance, and contact tracing, among Japan, South Korea, and Taiwan, the implementation and dissemination of measures were less strict, slower, and less comprehensive in Japan. This might explain why Japan has experienced a comparatively high incidence of COVID-19 and indicate a substantial risk of infection explosion. A change in behavioral compliance could trigger an infection explosion under poor performance in the response set. Further monitoring is warranted to promote the evolution of effective sets of countermeasures to overcome the pandemic.
Riemannian F-Manifolds, Bi-Flat F-Manifolds, and Flat Pencils of Metrics
Authors: Arsie Alessandro , Buryak Alexandr , Lorenzoni Paolo , Rossi Paolo 
Published: July 2021

AbstractIn this paper, we study relations between various natural structures on F-manifolds. In particular, given an arbitrary Riemannian F-manifold, we present a construction of a canonical flat F-manifold associated to it. We also describe a construction of a canonical homogeneous Riemannian F-manifold associated to an arbitrary exact homogeneous flat pencil of metrics satisfying a certain non-degeneracy assumption. In the last part of the paper, we construct Legendre transformations for Riemannian F-manifolds.
Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model
Authors: Abdelnabi Rana , Foo Caroline S , De Jonghe Steven , Maes Piet , Weynand Birgit , Neyts Johan 
Published: July 2021

AbstractThe emergence of SARS-CoV-2 variants of concern (VoCs) has exacerbated the COVID-19 pandemic. Currently available monoclonal antibodies and vaccines appear to have reduced efficacy against some of these VoCs. Antivirals targeting conserved proteins of SARS-CoV-2 are unlikely to be affected by mutations arising in VoCs and should therefore be effective against emerging variants. We here investigate the efficacy of molnupiravir, currently in phase 2 clinical trials, in hamsters infected with Wuhan strain or B.1.1.7 and B.1.351 variants. Molnupiravir proved to be effective against infections with each of the variants and therefore may have potential combating current and future emerging VoCs.
Characteristics and functions of glyceraldehyde 3-phosphate dehydrogenase S-nitrosylation during controlled aging of elm and Arabidopsis seeds
Authors: Zeng MeiYan , He YuQi , Gao Xue , Wang Yu , Deng ShiMing , Ye TianTian , Wang XiaoFeng , Xue Hua 
Published: July 2021

Abstract
Seed aging is the gradual decline in seed vigor, during which programmed cell death (PCD) occurs. The functions of nitric oxide (NO) are exerted through protein S-nitrosylation, a reversible post-translational modification. During seed aging, more than 80 proteins are S-nitrosylated, but the particular role of individual proteins is unknown. Here, we showed that the S-nitrosylation level of glyceraldehyde 3-phosphate dehydrogenase (UpGAPDH) in elm (Ulmus pumila L.) seeds increased after controlled deterioration treatment. UpGAPDH was S-nitrosylated at Cys154 during S-nitrosoglutathione (GSNO) treatment, and its oligomerization was triggered both in vitro and in elm seeds. Interestingly, UpGAPDH interacted with the mitochondrial voltage-dependent anion channel in an S-nitrosylation-dependent way. Some UpGAPDH–green fluorescent protein in Arabidopsis protoplasts co-localized with mitochondria during the GSNO treatment, while the S-nitrosylation-defective UpGAPDH C154S–GFP protein did not. Seeds of oxUpGAPDH lines showed cell death and lost seed vigor rapidly during controlled deterioration treatment-triggered seed aging, while those overexpressing S-nitrosylation-defective UpGAPDH-Cys154 did not. Our results suggest that S-nitrosylation of UpGAPDH may accelerate cell death and seed deterioration during controlled deterioration treatment. These results provide new insights into the effects of UpGAPDH S-nitrosylation on protein interactions and seed aging.
Superadiabaticity and the metallicity independence of the Humphreys–Davidson limit
Authors: Sabhahit Gautham N , Vink Jorick S , Higgins Erin R , Sander Andreas A C 
Published: July 2021

ABSTRACTThe Humphreys–Davidson (HD) limit sets the boundary between evolutionary channels of massive stars that end their lives either as the red supergiants (RSGs) or as the hotter blue supergiants (BSGs) and Wolf–Rayet stars. Mixing in the envelopes of massive stars close to their Eddington limit is crucial for investigating the upper luminosity limit of the coolest supergiants. We study the effects of excess mixing in superadiabatic layers that are dominated by radiation pressure, and we critically investigate the effects of mixing and mass-loss on the evolution of RSGs with log (Teff/K) &lt; 3.68 – as a function of metallicity. Using MESA, we produce grids of massive star models at three metallicities: Galactic (Z⊙), LMC $(\frac{1}{2}{\rm Z}_\odot)$, and SMC $(\frac{1}{5}{\rm Z}_\odot)$, with both high and low amounts of overshooting to study the upper luminosity limit of RSGs. We systematically study the effects of excess mixing in the superadiabatic layers of post-main-sequence massive stars, overshooting above the hydrogen core and yellow supergiant (YSG) mass-loss rates on the fraction of core helium burning time spent as a RSG. We find that the excess mixing in the superadiabatic layers is stronger at lower metallicities, as it depends on the opacities in the hydrogen bump at log (Teff/K) ≈ 4, which become more pronounced at lower metallicity. This shifts the cut-off luminosities to lower values at lower metallicities, thus balancing the first-order effect of mass-loss. The opposing effects of mass-loss and excess envelope mixing during post-main-sequence evolution of stars with higher overshooting potentially results in a metallicity-independent upper luminosity limit.
Stability analysis of the pickup ion ring-beam distributions in the outer heliosheath
Authors: Mousavi Ameneh , Liu Kaijun , Sadeghzadeh Sina 
Published: July 2021

ABSTRACT
The electromagnetic instabilities driven by the pickup ions in the outer heliosheath play a crucial role in interpreting the energetic neutral atom (ENA) ribbon observed by the Interstellar Boundary EXplorer (IBEX). Previous studies on the stability of the outer heliosheath pickup ions focused on ring-like velocity distributions with pickup angles equal or close to 90°. In this study, we investigate the instabilities driven by a ring-beam velocity distribution of the pickup ions in the outer heliosheath using linear instability analysis. The modes propagating along (both parallel and antiparallel to) the background magnetic field are examined, and the emphasis is on how the instabilities change with the pickup angle, α, varying from zero to 90°. The parallel thermal spread of the pickup ions is chosen to make the plasma parameters lie in the Alfvén cyclotron ‘stability gap’ to exclude the well-studied Alfvén cyclotron instability. Our linear instability analysis reveals that the unstable modes all have left helicity but may propagate parallel or antiparallel to the background magnetic field. At small α, the parallel-propagating modes are unstable in two separate wavenumber (and frequency) ranges. The two unstable ranges merge into one when α increases to 82°. In addition, the antiparallel-propagating modes become unstable when α is above 5°, but the parallel-propagating modes have larger growth rates until α becomes larger than αc = 82.8°. The growth rates of the parallel-propagating modes quickly drop below zero when α goes beyond αc, while the antiparallel-propagating modes remain unstable until α approaches 90°.
Full-sky integrated Sachs–Wolfe maps for the MICE grand challenge lightcone simulation
Authors: Naidoo Krishna , Fosalba Pablo , Whiteway Lorne , Lahav Ofer 
Published: July 2021

ABSTRACT
We present full-sky maps of the Integrated Sachs–Wolfe effect (ISW) for the MICE Grand Challenge lightcone simulation up to redshift 1.4. The maps are constructed in the linear regime using spherical Bessel transforms. We compare and contrast this procedure against analytical approximations found in the literature. By computing the ISW in the linear regime, we remove the substantial computing and storage resources required to calculate the non-linear Rees–Sciama effect. Since the linear ISW at low redshift z ≲ 1, at large angular scales, and after matter domination is ${\sim}10^{2}\, \mathrm{ times}$ larger in ΔT/T, this has a negligible impact on the maps produced and only becomes relevant on scales which are dominated by cosmic microwave background (CMB) anisotropies. The MICE simulation products have been extensively used for studies involving current and future galaxy surveys. The availability of these maps will allow MICE to be used for future galaxy and CMB cross-correlation studies, ISW reconstruction studies, and ISW void-stacking studies probed by galaxy surveys such as Dark Energy Survey, Dark Energy Spectroscopic Instrument, Euclid, and Rubin Legacy Survey of Space and Time. The pipeline developed in this study is provided as a public Python package pyGenISW. This could be used in the future studies for constructing the ISW from existing and future simulation suites probing vast sets of cosmological parameters and models.
A Gemini–NIFS view of the merger remnant NGC 34
Authors: Motter J C , Riffel R , Ricci T V , Riffel R A , Storchi-Bergmann T , Pastoriza M G , Rodriguez-Ardila A , Ruschel-Dutra D , Dahmer-Hahn L G , Dametto N Z , Diniz M R 
Published: July 2021

ABSTRACT
The merger remnant NGC 34 is a local luminous infrared galaxy (LIRG) hosting a nuclear starburst and a hard X-ray source associated with a putative, obscured Seyfert 2 nucleus. In this work, we use adaptive optics assisted near-infrared (NIR) integral field unit observations of this galaxy to map the distribution and kinematics of the ionized and molecular gas in its inner $\mathrm{1.2\, kpc \times 1.2\, kpc}$, with a spatial resolution of 70 pc. The molecular and ionized gas kinematics is consistent with a disc with projected major axis along a mean PA = −9${_{.}^{\circ}}$2 ± 0${_{.}^{\circ}}$9. Our main findings are that NGC 34 hosts an AGN and that the nuclear starburst is distributed in a circumnuclear star formation ring with inner and outer radii of ≈ 60 and 180 pc, respectively, as revealed by maps of the $\mathrm{[Fe\, {\small {II}}] / Pa\,\beta }$ and H2/Br γ emission-line ratios, and corroborated by PCA tomography analysis. The spatially resolved NIR diagnostic diagram of NGC 34 also identifies a circumnuclear structure dominated by processes related to the stellar radiation field and a nuclear region where $[\rm Fe\, {\small {II}}]$ and H2 emissions are enhanced relative to the hydrogen recombination lines. We estimate that the nuclear X-ray source can account for the central H2 enhancement and conclude that $[\rm Fe\, {\small {II}}]$ and H2 emissions are due to a combination of photoionization by young stars, excitation by X-rays produced by the AGN and shocks. These emission lines show nuclear, broad, blueshifted components that can be interpreted as nuclear outflows driven by the AGN.
Diffusion as a leading dissipative mechanism in superconducting neutron stars
Authors: Kraav K Y , Gusakov M E , Kantor E M 
Published: July 2021

ABSTRACT
Despite the fact that different particle species can diffuse with respect to each other in neutron star (NS) cores, the effect of particle diffusion on various phenomena associated with NS oscillations is usually ignored. Here, we demonstrate that the diffusion can be extremely powerful dissipative mechanism in superconducting NSs. In particular, it can be much more efficient than the shear and bulk viscosities. This result has important implications for the damping times of NS oscillations, development, and saturation of dynamical instabilities in NSs, and for the excitation and coupling of oscillation modes during the late inspiral of binary NSs.
Discovering single nucleotide variants and indels from bulk and single-cell ATAC-seq
Authors: Massarat Arya R , Sen Arko , Jaureguy Jeff , Tyndale Sélène T , Fu Yi , Erikson Galina , McVicker Graham 
Published: July 2021

AbstractGenetic variants and de novo mutations in regulatory regions of the genome are typically discovered by whole-genome sequencing (WGS), however WGS is expensive and most WGS reads come from non-regulatory regions. The Assay for Transposase-Accessible Chromatin (ATAC-seq) generates reads from regulatory sequences and could potentially be used as a low-cost ‘capture’ method for regulatory variant discovery, but its use for this purpose has not been systematically evaluated. Here we apply seven variant callers to bulk and single-cell ATAC-seq data and evaluate their ability to identify single nucleotide variants (SNVs) and insertions/deletions (indels). In addition, we develop an ensemble classifier, VarCA, which combines features from individual variant callers to predict variants. The Genome Analysis Toolkit (GATK) is the best-performing individual caller with precision/recall on a bulk ATAC test dataset of 0.92/0.97 for SNVs and 0.87/0.82 for indels within ATAC-seq peak regions with at least 10 reads. On bulk ATAC-seq reads, VarCA achieves superior performance with precision/recall of 0.99/0.95 for SNVs and 0.93/0.80 for indels. On single-cell ATAC-seq reads, VarCA attains precision/recall of 0.98/0.94 for SNVs and 0.82/0.82 for indels. In summary, ATAC-seq reads can be used to accurately discover non-coding regulatory variants in the absence of whole-genome sequencing data and our ensemble method, VarCA, has the best overall performance.
Protected areas safeguard landbird populations in central coastal California: Evidence from long-term population trends
Authors: Dettling Mark D , Dybala Kristen E , Humple Diana L , Gardali Thomas 
Published: July 2021

Abstract
Many bird populations have experienced population declines across North America over the past several decades. The establishment of protected areas has been used as a conservation action to maintain or help in the recovery of these populations; however, the effectiveness of protected areas in safeguarding bird populations within their borders from negative impacts to populations in surrounding unprotected areas has rarely been evaluated. Our study aimed to evaluate the effectiveness of protected areas in the San Francisco Bay Area of California for landbirds. We conducted point count surveys along riparian corridors in coastal Marin County in protected areas, predominately national parks, and estimated the population growth rates for 14 species over 23 years. We compared these growth rates to North American Breeding Bird Survey growth rate estimates from the Coastal California and the Northern Pacific Rainforest Bird Conservation Regions, which comprise larger, regional populations. A safeguarding effect was detected for 9 of the 14 species. We expected an effect on species strongly associated with riparian vegetation, which has incurred significant loss and degradation in the region; however, we instead observed benefits to general riparian users that were at least as great as the benefits to strong riparian specialists. We also expected that populations of resident species might benefit more than migrants; however, we found strong support for a safeguarding effect for both groups. Species with increasing growth rates in coastal Marin County protected areas in comparison to regionally stable or decreasing populations demonstrate the potential for protected areas to not only maintain populations despite declines outside their boundaries but also to help them recover from current and previous losses. Continuing long-term monitoring and associated full life cycle research will help identify if and when other drivers (e.g., climate change) may weaken these safeguarding effects, or when additional conservation and management is warranted.
Co-Presentation of Posterior Reversible Encephalopathy Syndrome in a Patient with Post–Dural Puncture Headache
Authors: Sagir Afrin , Ahuja Sanchit , Soliman Loran Mounir , Farag Ehab 
Published: July 2021

Abstract

Introduction
Post–dural puncture headache (PDPH) is a well-known complication of neuraxial anesthesia, but the occurrence of seizures and vision loss within a few days after dural puncture could be alarming. Posterior reversible encephalopathy syndrome (PRES) is associated with reversible edema and leukoencephalopathy in the posterior parieto-occipital cortex. We report the co-presentation of PRES and PDPH after labor epidural analgesia.

Case Presentation
A 25-year-old multiparous African-American woman was admitted for evaluation of new-onset seizures and headache in the postpartum period. She had a recent history of multiple needle insertion attempts and inadvertent dural puncture during epidural analgesia for delivery. Soon after delivery, she was diagnosed with PDPH and was treated with an epidural blood patch, with no relief of symptoms. Six days later, she developed sudden-onset transient blindness, seizures, and altered sensorium, and magnetic resonance imaging of the brain revealed white matter changes suggestive of PRES.

Conclusion
PRES is an uncommon complication of cerebrospinal fluid leak and intracranial hypotension. We report the occurrence of PRES in a patient with no known risk factors except a traumatic dural tap. Is it important to expand the differentials for headache after dural puncture to encompass PRES as a possibility, especially in patients with a delayed presentation of seizures and cortical blindness.
Generational Persistence in the Nature of White Racial Attitudes
Authors: Engelhardt Andrew M 
Published: July 2021

AbstractRace and racial attitudes are central to American politics. To understand these relationships, scholars often use measures developed in earlier social and political contexts. A key issue is thus whether such measures consistently capture the same construct across varied contexts. Changes in the social and political context may result in generational differences in how people interpret certain racial attitude items given different socialization experiences. Such differences make generational comparisons on these items invalid because the items capture different considerations. I build on recent work investigating this possibility and test the racial resentment measure’s equivalence between Millennial and older Whites. Despite potential generational differences, I find that the racial resentment measure operates equivalently across generations using two different analytical approaches (retrospective thought-listing and multi-group confirmatory factor analysis). The racial resentment measure offers valid insights into racial attitudes across generational cohorts. I conclude by discussing what this finding implies for emerging work on the manifestations of prejudiced attitudes among Millennial Whites and also suggest potential points of improvement for the measure.
Juvenile idiopathic arthritis, marriage and parenthood: a nationwide matched cohort study
Authors: Bruze Gustaf , Askling Johan , Horne AnnaCarin , Neovius Martin 
Published: July 2021

Abstract

Objectives
To compare trajectories of marriage and parenthood in individuals with JIA vs the general population.

Methods
Patients with JIA (n = 4399) were identified in the Swedish National Patient Register (2001–2016) and individually matched to up to five general population comparators on birthyear, sex and residence county (n = 21 981). Marriage and parenthood data were retrieved from the Total Population Register from age 18 y, and parenthood from the Multigeneration Register from age 15 y, respectively. Hazard ratios (HRs) were estimated using Cox regression adjusted for parental education, parental marital status and number of siblings.

Results
During a median of 6.3 years of follow-up, 362 patients with JIA and 1744 comparators got married (12.9 vs. 12.5 per 1000 person-years; HR 1.03, 95%CI 0.93-1.15). During a median of 8.8 years of follow-up, 680 patients with JIA and 3477 matched comparators became parents (17.1 vs 17.8 per 1000 person-years; HR 0.94, 95%CI 0.87-1.01). In the subgroup of patients with systemic onset JIA (SJIA), the adjusted hazard ratios for marriage and parenthood were 0.79 (95%CI 0.53-1.17) and 0.73 (95%CI 0.55-0.97), respectively.

Conclusion
The times to first marriage and first parenthood are similar for patients with JIA and the general population, suggesting that adolescents with JIA transition into family life along a trajectory resembling their community peers. One exception is the subgroup of patients with systemic onset JIA, who become parents for the first time at a lower rate than general population comparators.
A 7-Tesla MRI study of the periaqueductal gray: resting state and task activation under threat
Authors: Weis Carissa N , Bennett Kenneth P , Huggins Ashley A , Parisi Elizabeth A , Gorka Stephanie M , Larson Christine 
Published: July 2021

Abstract
The periaqueductal gray (PAG) is a region of the midbrain implicated in a variety of behaviors including defensive responses to threat. Despite the wealth of knowledge pertaining to the differential functional roles of the PAG columns in nonhuman and human research, the basic functional connectivity of the PAG at rest has not been well characterized. Therefore, the current study utilized 7-Tesla magnetic resonance imaging (MRI) to characterize PAG functional connectivity at rest and task activation under uncertain threat. A sample of 53 neurologically healthy undergraduate participants (Mage = 22.2, s.d.age = 3.62) underwent structural and resting state functional MRI scans. Supporting previous work, voxel-wise analyses showed that the PAG is functionally connected to emotion regulation and fear networks. The comparison of functional connectivity of PAG columns did not reveal any significant differences. Thirty-five participants from the same sample also completed an uncertain threat task with blocks of three conditions—no shock, predictable shock and unpredictable shock. There were no robust activity differences within the PAG columns or the whole PAG across conditions although there was differential activity at the voxel level in the PAG and in other regions theoretically relevant to uncertain threat. Results of this study elucidate PAG connectivity at rest and activation in response to uncertain threat.