bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addressing alpine plant phylogeography using integrative distributional, demographic and coalescent modeling
Authors: Larsson Dennis J. , Pan Da , Schneeweiss Gerald M. 
Published: July 2021

AbstractPhylogeographic studies of alpine plants have evolved considerably in the last two decades from ad hoc interpretations of genetic data to statistical model-based approaches. In this review we outline the developments in alpine plant phylogeography focusing on the recent approach of integrative distributional, demographic and coalescent (iDDC) modeling. By integrating distributional data with spatially explicit demographic modeling and subsequent coalescent simulations, the history of alpine species can be inferred and long-standing hypotheses, such as species-specific responses to climate change or survival on nunataks during the last glacial maximum, can be efficiently tested as exemplified by available case studies. We also discuss future prospects and improvements of iDDC.
Glue, Onyx, Squid or PHIL? Liquid Embolic Agents for the Embolization of Cerebral Arteriovenous Malformations and Dural Arteriovenous Fistulas
Authors: Vollherbst Dominik F. , Chapot René , Bendszus Martin , Möhlenbruch Markus A. 
Published: July 2021

Abstract
Background
Endovascular embolization is an effective treatment option for cerebral arteriovenous malformations (AVMs) and dural arteriovenous fistulas (DAVFs). A variety of liquid embolic agents have been and are currently used for embolization of AVMs and DAVFs. Knowledge of the special properties of the agent which is used is crucial for an effective and safe embolization procedure.

Material and Methods
This article describes the properties and indications of the liquid embolic agents which are currently available: cyanoacrylates (also called glues), and the copolymers Onyx, Squid and PHIL, as well as their respective subtypes.

Results
Cyanoacrylates were the predominantly used agents in the 1980s and 1990s. They are currently still used in specific situations, for example for the occlusion of macro-shunts, for the pressure cooker technique or in cases in which microcatheters are used that are not compatible with dimethyl-sulfoxide. The first broadly used copolymer-based embolic agent Onyx benefits from a large amount of available experience and data, which demonstrated its safety and efficacy in the treatment of cerebral vascular malformations, while its drawbacks include temporary loss of visibility during longer injections and artifacts in cross-sectional imaging. The more recently introduced agents Squid and PHIL aim to overcome these shortcomings and to improve the success rate of endovascular embolization. Novelties of these newer agents with potential advantages include extra-low viscosity versions, more stable visibility, and a lower degree of imaging artifacts.

Conclusion
All the available liquid embolic agents feature specific potential advantages and disadvantages over each other. The choice of the most appropriate embolic agent must be made based on the specific material characteristics of the agent, related to the specific anatomical characteristics of the target pathology.
Comparison of different approaches to derive classical bonded force-field parameters for a transition metal cofactor: a case study for non-heme iron site of ectoine synthase
Authors: Andrys Justyna , Heider Johann , Borowski Tomasz 
Published: July 2021

AbstractComputational investigations into the structure and function of metalloenzymes with transition metal cofactors require proper preparation of the model, which requires obtaining reliable force field parameters for the cofactor. Here, we present a test case where several methods were used to derive amber force field parameters for a bonded model of the Fe(II) cofactor of ectoine synthase. Moreover, the spin of the ground state of the cofactor was probed by DFT and post-HF methods, which consistently indicated the quintet state is lowest in energy and well separated from triplet and singlet. The performance of the obtained force field parameter sets, derived for the quintet spin state, was scrutinized and compared taking into account metrics focused on geometric features of the models as well as their energetics. The main conclusion of this study is that Hessian-based methods yield parameters which represent the geometry around the metal ion, but poorly reproduce energy variance with geometrical changes. On the other hand, the energy-based method yields parameters accurately reproducing energy-structure relationships, but with bad performance in geometry optimization. Preliminary tests show that admixing geometrical criteria to energy-based methods may allow to derive parameters with acceptable performance for both energy and geometry.
The pharmacokinetic interaction between nasally administered naloxone and the opioid remifentanil in human volunteers
Authors: Tylleskar Ida , Skarra Sissel , Skulberg Arne Kristian , Dale Ola 
Published: July 2021

Abstract
Purpose
Remifentanil has been shown to increase the bioavailability of nasally administered naloxone. The aim of this study was to explore the nature of this observation.

Methods
We analysed samples from three pharmacokinetic studies to determine the serum concentrations of naloxone-3-glucuronide (N3G), the main metabolite of naloxone, with or without exposure to remifentanil. To enable direct comparison of the three studies, the data are presented as metabolic ratios (ratio of metabolite to mother substance, N3G/naloxone) and dose-corrected values of the area under the curve and maximum concentration (Cmax).

Results
Under remifentanil exposure, the time to maximum concentration (Tmax) for N3G was significantly higher for intranasal administration of 71 min compared to intramuscular administration of 40 min. The dose-corrected Cmax of N3G after intranasal administration of naloxone under remifentanil exposure was significantly lower (4.5 ng/mL) than in subjects not exposed to remifentanil (7.8–8.4 ng/mL). The metabolic ratios after intranasal administration rose quickly after 30–90 min and were 2–3 times higher at 360 min compared to intravenous and intramuscular administration. Remifentanil exposure resulted in a much slower increase of the N3G/naloxone ratio after intranasal administration compared to intranasal administration with the absence of remifentanil. After remifentanil infusion was discontinued, this effect gradually diminished. From 240 min there was no significant difference between the ratios observed after intranasal naloxone administration.

Conclusion
Remifentanil increases the bioavailability of naloxone after nasal administration by reducing the pre-systemic metabolism of the swallowed part of the nasal dose.
Fear of sex: sexual conflict exposed as avoidance in a parthenogenetic invertebrate
Authors: Lee Marcus , Solano Udina Carlota , Hansson Lars-Anders 
Published: July 2021

Abstract
Males and females often have divergent evolutionary interests, generating sexual conflicts. This is particularly true in organisms that exhibit facultative sexuality, whereby females are capable of reproducing without fitness costs of mating. Here, we provide the first documented evidence with quantitative tracking showing that sex interacts with social context to determine space-use of females, in a pattern resembling predator avoidance. To achieve this, we labelled Daphnia magna with fluorescent nanoparticles and utilized a 3-D tracking platform to record pairs of individuals swimming. The recordings comprised either same-sex or opposite-sex pairings. We found that females swam faster, deeper, more horizontally, and more linearly when exposed to males than when exposed to females. Simultaneously, we found that male behavior did not differ depending on swimming partner and, importantly, we observed no sexual dimorphism in swimming behaviors when swimming with the same sex. Our results suggest that the presence of males in a population has the potential to influence the distribution of individuals, similarly to known threats, such as predation. This highlights that sexual conflict has clear spatial consequences and should be considered in such ecological frameworks, like the Landscape of Fear (LOF) concept. In a broader context, the connection of the evolutionary and social concept of sexual conflict and the ecological concept of LOF may improve our understanding of population dynamics and the spatial and temporal distribution of individuals in natural ecosystems.

Significance statement
Despite the wealth of studies that detail how predators affect their prey’s spatial behaviors, studies on the role of sex and social context on spatial behavior are rare. Addressing this dearth of information, we studied the swimming behaviors of an organism that can reproduce with or without sex, when exposed to an individual of either the same or opposite sex. We found no difference between the sexes in swimming behaviors; however, we revealed that females avoided males by swimming deeper in the water column, reminiscent of the response to predation. Our results highlight that social conflict between the sexes strongly affects the demographics of a population and may therefore have a substantial role in the spatial ecology of organisms in the wild.
Coping and Adaptation in Response to Environmental and Climatic Stressors in Caribbean Coastal Communities
Authors: Touza Julia , Lacambra Carmen , Kiss Alexandra , Amboage Rosa Mato , Sierra Paula , Solan Martin , Godbold Jasmin A. , Spencer Thomas , White Piran C. L. 
Published: July 2021

AbstractCumulative and synergistic impacts from environmental pressures, particularly in low-lying tropical coastal regions, present challenges for the governance of ecosystems, which provide natural resource-based livelihoods for communities. Here, we seek to understand the relationship between responses to the impacts of El Niño and La Niña events and the vulnerability of mangrove-dependent communities in the Caribbean region of Colombia. Using two case study sites, we show how communities are impacted by, and undertake reactive short-term responses to, El Niño and La Niña events, and how such responses can affect their adaptive capacity to progressive environmental deterioration. We show that certain coping measures to climate variability currently deliver maladaptive outcomes, resulting in circumstances that could contribute to system ‘lock-in’ and engender undesirable ecological states, exacerbating future livelihood vulnerabilities. We highlight the significant role of social barriers on vulnerabilities within the region, including perceptions of state abandonment, mistrust and conflicts with authorities. Opportunities to reduce vulnerability include enhancing the communities’ capacity to adopt more positive and preventative responses based on demonstrable experiential learning capacity. However, these will require close cooperation between formal and informal organisations at different levels, and the development of shared coherent adaptation strategies to manage the complexity of multiple interacting environmental and climatic pressures.
Effect of Endoscopic Appendix Intubation and Irrigation on Acute Uncomplicated Appendicitis
Authors: Zhang Pei‐Hong , Wei Jing‐Jing , Lian Ting‐Ting , Jiang Ying , Zhuang Ze‐Hao 
Published: July 2021

AbstractObjectiveTo investigate the efficacy and safety of endoscopic appendix intubation and irrigation (EAI) on acute uncomplicated appendicitis.MethodsThis prospective non‐randomized study examined 169 patients with suspected acute uncomplicated appendicitis at The First Affiliated Hospital of Fujian Medical University from October 2015 to 2017. Patients were divided into three groups: endoscopic appendix intubation and irrigation (EAI, n = 18), laparoscopic appendectomy (LA, n = 87), and antibiotic alone (A, n = 64). The treatment success rate, duration of hospitalization, medical costs, operation time, duration of abdominal pain, fasting time, complications, and recurrence were analyzed.ResultsThe three groups had no significant differences in baseline characteristics (age, gender, Alvarado score, white blood cell count, and neutrophil count; all P > 0.05). Compared to the LA group, the EAI group had shorter durations of the operation, fasting, and abdominal pain; less use of oral and intravenous antibiotics; and lower medical costs (all P < 0.05). Compared to the A group, the EAI group had shorter durations of abdominal pain and hospitalization, and less use of intravenous antibiotics (all P < 0.05). The EAI group had no complications, but 3 patients (3.4%) in the LA group had surgery‐related complications.ConclusionEAI is a safe and effective treatment for acute uncomplicated appendicitis. Patients who received EAI had shorter durations of abdominal pain and hospitalization than those who received LA or conservative antibiotic treatment.Trial registration number and agencyChiCTR‐IPN‐15006565, Chinese Clinical Trial Registry
Influence of platelet count at diagnosis and during the course of disease on prognosis in MDS patients
Authors: Strapatsas Judith , Barbulescu Elena Calina , Lauseker Michael , Kaivers Jennifer , Hildebrandt Barbara , Nachtkamp Kathrin , Strupp Corinna , Rudelius Martina , Haas Rainer , Germing Ulrich 
Published: July 2021

AbstractThrombocytopenia at diagnosis and platelet drop within the first 6 months have an adverse effect on prognosis of MDS patients. We therefore were interested in the association and impact on prognosis of morphologic findings of megakaryocytes and platelets with platelet count at diagnosis, bleeding complications, and the drop of platelets during the course of disease. This retrospective analysis was based on 334 MDS patients from the Duesseldorf MDS registry that were followed up for blood counts, bleeding, transfusion dependency, and AML evolution and correlated with morphology of the megakaryocytes and platelets. Thrombocytopenia was found more frequently in higher risk MDS and was associated with hypocellularity of the megakaryocytes in the bone marrow. Signs of bleeding were present at diagnosis in 14% and occurred during the disease in 48% of all MDS patients. Death due to bleeding was ranked third behind infections and AML. A decrement of platelets during the first 6 months was associated with an inferior overall survival of 21 vs. 49 months and with a higher cumulative 2-year AML rate of 22.2% vs. 8.3% (p = 0.001). In a multivariate analysis, besides bone marrow blasts and karyotype, decreasing platelets were also associated with an inferior outcome. Signs of bleeding are present in a relevant number of MDS patients and account for significant morbidity and mortality in MDS. We could demonstrate the prognostic importance of decreasing platelets during the course of disease in all MDS patients, identifying patients at higher risk for death or AML progression.
Value-based Engineering: Prinzipien und Motivation für bessere IT-Systeme
Authors: Spiekermann Sarah 
Published: July 2021

ZusammenfassungDigitale Ethik wird derzeit weltweit als eine Notwendigkeit diskutiert, um verlässlichere IT-Systeme zu schaffen. Diese Diskussion, geschürt durch die Angst vor einer unkontrollierbaren generellen Künstlichen Intelligenz (KI) und angeheizt von ethischen Dilemmata bestehender Systeme, hat viele Institutionen und Wissenschaftler dazu bewegt, Werteprinzipien einzufordern, an denen sich die Entwicklung komplexer Systeme zukünftig orientieren sollte. Diese inkludieren i. d. R. die Forderung nach Privatsphäre, Sicherheit, Transparenz, Fairness etc. In diesem Artikel wird dargestellt, warum das Abarbeiten von Wertelisten für eine gute bzw. ethisch legitimierte Systementwicklung unzureichend ist. Es wird gezeigt, wie stattdessen ein wirklich ethisches „Value-based Engineering“ aussehen müsste, damit technische Produktinnovationen insgesamt auf bessere (ethischere) Füße gestellt werden. Value-based Engineering (VbE) ist eine prozessgetriebene, ganzheitliche Herangehensweise an die Systementwicklung, die zunächst aus den Ideen des Value Sensitive Designs und dem Ethical Computing schöpfte. Ab 2016 wurde VbE im IEEE 7000 Standard weiter konkretisiert. 10 Prinzipien für ethisch angeleitete Systeminnovation fassen wesentliche Handlungsanforderungen für Unternehmen zusammen.
CT-based thermometry with virtual monoenergetic images by dual-energy of fat, muscle and bone using FBP, iterative and deep learning–based reconstruction
Authors: Heinrich Andreas , Schenkl Sebastian , Buckreus David , Güttler Felix V. , Teichgräber Ulf K-M. 
Published: July 2021

Abstract
Objectives
The aim of this study was to evaluate the sensitivity of CT-based thermometry for clinical applications regarding a three-component tissue phantom of fat, muscle and bone. Virtual monoenergetic images (VMI) by dual-energy measurements and conventional polychromatic 120-kVp images with modern reconstruction algorithms adaptive statistical iterative reconstruction-Volume (ASIR-V) and deep learning image reconstruction (DLIR) were compared.

Methods
A temperature-regulating water circuit system was developed for the systematic evaluation of the correlation between temperature and Hounsfield units (HU). The measurements were performed on a Revolution CT with gemstone spectral imaging technology (GSI). Complementary measurements were performed without GSI (voltage 120 kVp, current 130–545 mA). The measured object was a tissue equivalent phantom in a temperature range of 18 to 50°C. The evaluation was carried out for VMI at 40 to 140 keV and polychromatic 120-kVp images.

Results
The regression analysis showed a significant inverse linear dependency between temperature and average HU regardless of ASIR-V and DLIR. VMI show a higher temperature sensitivity compared to polychromatic images. The temperature sensitivities were 1.25 HU/°C (120 kVp) and 1.35 HU/°C (VMI at 140 keV) for fat, 0.38 HU/°C (120 kVp) and 0.47 HU/°C (VMI at 40 keV) for muscle and 1.15 HU/°C (120 kVp) and 3.58 HU/°C (VMI at 50 keV) for bone.

Conclusions
Dual-energy with VMI enables a higher temperature sensitivity for fat, muscle and bone. The reconstruction with ASIR-V and DLIR has no significant influence on CT-based thermometry, which opens up the potential of drastic dose reductions.

Key Points
• Virtual monoenergetic images (VMI) enable a higher temperature sensitivity for fat (8%), muscle (24%) and bone (211%) compared to conventional polychromatic 120-kVp images.
• With VMI, there are parameters, e.g. monoenergy and reconstruction kernel, to modulate the temperature sensitivity. In contrast, there are no parameters to influence the temperature sensitivity for conventional polychromatic 120-kVp images.
• The application of adaptive statistical iterative reconstruction-Volume (ASIR-V) and deep learning–based image reconstruction (DLIR) has no effect on CT-based thermometry, opening up the potential of drastic dose reductions in clinical applications.
Linear extension, skeletal density, and calcification rates of the blue coral Heliopora coerulea
Authors: Courtney Travis A. , Guest James R. , Edwards Alasdair J. , Dizon Romeo M. 
Published: July 2021

AbstractThe brooding reef-building octocoral Heliopora is widespread on Indo-West Pacific reefs and appears to be relatively resistant to thermal stress, which may enable it to persist locally while scleractinians diminish under Anthropocene conditions. However, basic physiological measurements of “blue corals” are lacking and prevent their inclusion in trait-based studies. We address this by quantifying rates (mean ± SE) of linear extension (0.86 ± 0.05 cm yr−1) and skeletal density (2.01 ± 0.06 g cm−3) to estimate calcification rates (0.87 ± 0.08 g cm−2 yr−1) for the small branching/columnar morphology of Heliopora coerulea. We postulate that H. coerulea may become an increasingly important reef-builder under ocean warming due to its relative resistance to thermal stress and high skeletal density that make colonies less vulnerable to storm damage under ocean acidification. Moreover, Heliopora corals are likely dispersal limited suggesting they may be an underappreciated genus for restoration of stress-tolerant reef-building capacity on degraded reefs.
Influence of Arctic sea-ice loss on the Greenland ice sheet climate
Authors: Sellevold Raymond , Lenaerts Jan T. M. , Vizcaino Miren 
Published: July 2021

AbstractThe Arctic is the region on Earth that is warming the fastest. At the same time, Arctic sea ice is reducing while the Greenland ice sheet (GrIS) is losing mass at an accelerated pace. Here, we study the seasonal impact of reduced Arctic sea ice on GrIS surface mass balance (SMB), using the Community Earth System Model version 2.1 (CESM2), which features an advanced, interactive calculation of SMB. Addressing the impact of sea-ice reductions on the GrIS SMB from observations is difficult due to the short observational records. Also, signals detected using transient climate simulations may be aliases of other forcings. Here, we analyze dedicated simulations from the Polar Amplification Model Intercomparison Project with reduced Arctic sea ice and compare them with preindustrial sea ice simulations while keeping all other forcings constant. In response to reduced sea ice, the GrIS SMB increases in winter due to increased precipitation, driven by the more humid atmosphere and increasing cyclones. In summer, surface melt increases due to a warmer, more humid atmosphere providing increased energy transfer to the surface through the sensible and latent heat fluxes, which triggers the melt-albedo feedback. Further, warming occurs throughout the entire troposphere over Baffin Bay. This deep warming results in regional enhancement of the 500 hPa geopotential heights over the Baffin Bay and Greenland, increasing blocking and heat advection over the GrIS’ surface. This anomalous circulation pattern has been linked to recent increases in the surface melt of the GrIS.
Prognostic nomogram to predict the overall survival of patients with early-onset colorectal cancer: a population-based analysis
Authors: Wu Junxian , Lu Linbin , Chen Hong , Lin Yihong , Zhang Huanlin , Chen Enlin , Lin Weiwei , Li Jie , Chen Xi 
Published: July 2021

Abstract
Purpose
The present study aimed to identify independent clinicopathological and socio-economic prognostic factors associated with overall survival of early-onset colorectal cancer (EO-CRC) patients and then establish and validate a prognostic nomogram for patients with EO-CRC.

Methods
Eligible patients with EO-CRC diagnosed from 2010 to 2017 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were randomly divided into a training cohort and a testing cohort. Independent prognostic factors were obtained using univariate and multivariate Cox analyses and were used to establish a nomogram for predicting 3- and 5-year overall survival (OS). The discriminative ability and calibration of the nomogram were assessed using C-index values, AUC values, and calibration plots.

Results
In total, 5585 patients with EO-CRC were involved in the study. Based on the univariate and multivariate analyses, 15 independent prognostic factors were assembled into the nomogram to predict 3- and 5-year OS. The nomogram showed favorable discriminatory ability as indicated by the C-index (0.840, 95% CI 0.827–0.850), and the 3- and 5-year AUC values (0.868 and 0.84869 respectively). Calibration plots indicated optimal agreement between the nomogram-predicted survival and the actual observed survival. The results remained reproducible in the testing cohort. The C-index of the nomogram was higher than that of the TNM staging system (0.840 vs 0.804, P < 0.001).

Conclusion
A novel prognostic nomogram for EO-CRC patients based on independent clinicopathological and socio-economic factors was developed, which was superior to the TNM staging system. The nomogram could facilitate postoperative individual prognosis prediction and clinical decision-making.