bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimisation of Cutting Fluid Concentration and Operating Parameters based on RSM for Turning Ti–6Al–4V
Authors: Gariani Salah , Elsayed Mahmoud , Shyha Islam 
Published: April 2021

Abstract
The paper details experimental and optimisation results for the effect of cutting fluid concentration and operating parameters on the average surface roughness (Ra) and tool flank wear (VB) when flooded turning of Ti-6Al-4V using water-miscible vegetable oil-based cutting fluid. Cutting fluid concentration, cutting speed, feed rate and cutting tool were the control variables. Response Surface Methodology (RSM) was employed to develop an experimental design and optimise Ra and VB using linear models. The study revealed that cutting fluid concentration has a little influence on Ra and VB performance while Ra was strongly affected by feed rate and cutting tool type. The developed empirical model also suggested that the best parameters setting to minimise Ra and VB are 5%, 58 m/min, 0.1 mm/rev for cutting fluid concentration, cutting speed and feed rate, respectively, using H13A tool. At this setting, the predicted surface roughness and tool wear were 0.48 and 30 µm, respectively. In the same vein, tool life and micro-hardness tests were performed at the suggested optimum cutting condition with different cutting speeds. A notable decrease in tool life (82.3%) was obtained when a higher cutting speed was used.
Effects of control measures and their importance on COVID-19 transmission dynamics
Authors: Supatgiat Chonawee 
Published: April 2021

Abstract
For more than a year, governments around the world have attempted to control the COVID-19 pandemic. Control measures such as social distancing, face mask wearing, business/school closure, city or transportation lockdown, ban of mass gathering, population education and engagement, contact tracing, and improved mass testing protocols are being used to contain the pandemic. Currently, there are no studies to date that rank the importance of these measures so that the governments may allocate and target their resources towards the most effective control measures. In this paper, we propose a Discrete Time Markov Chain model that captures the above control measures and ranks them. We also show that the importance of the measures change overtime and depends on the stage of the transmission dynamics, as well as the environment. For example, contract tracing is known to be a powerful measure to effectively control the pandemic, however its influence is dynamic in nature. Our results show that contact tracing is indeed helpful during the early stage of the pandemic, but becomes less important after a vaccination program takes effect. If implemented, our novel and unique model may assist many countries in their crucial pandemic control decisions.
Determinants of Stroke Mortality through Survival Models: The case of Mettu Karl Referral hospital, Mettu, Ethiopia
Authors: Ababu Dereje Gebeyehu , Getahun Azmeraw Misganaw 
Published: April 2021

Abstract
Introduction: Every year worldwide between five to six million deaths are associated with stroke; on average, one stroke-related death occurs every four min. In Ethiopia, stroke is a frequent cause of mortality and morbidity from non-communicable diseases. Therefore, this study was aimed to determine factors associated to stroke mortality through survival models in Mettu Carl Referral Hospital.Methods: This study was conducted from September 1, 2014 to April 1, 2017, and encompassed 202 stroke patients at Mettu Carl Referral Hospital. The Cox Semi-parametric regression and parametric PH Weibull, Exponential, Log-logistic and log-normal models were used for analyzing survival analysis of stroke patients using R software. Results: A totals of 202 stroke patients were included in the study and among those patients 72.8% and 27.2% were censored and died respectively. According the result of Weibull proportional hazard model, gender of patients (HR=1.5052200, p-value<0.0000207), hypertension (HR= 0.7135953, p-value<0.000737), and baseline complication (HR=0.7246955, p-value<0.00229), had significant effect on survival of the stroke patient.Conclusion: The estimated survival and hazard rate of stroke patients under gender of patients, baseline complication and hypertension had significant difference with p-values less than 0.05. Finally, the findings of this study implied that Hypertension, sex of the patients, and baseline complication were major factors related to survival time of stroke patients. The researcher recommends that the people should aware on the burden of those risk factors and well informed about the disease.
Accuracy Evaluation of Broadcast Ephemeris for BDS-2 and BDS-3
Authors: Jian Hao Jun , Wang Yishi , Zhang Shoujian 
Published: April 2021

Abstract
The BDS-3 system was completed in July 2020 and began to provide services to users around the world. The inspection of its operation, especially the detailed evaluation of the orbit, clock error, TGD and other indicators, plays an important role in the subsequent positioning. This study conducts an investigation of the satellite broadcast ephemeris of the BDS-2 and BDS-3. The difference between the satellite orbit position calculated by the broadcast ephemeris and the position calculated by the precise ephemeris is used for analysis. First, the ephemeris form January 2020 to February 2020 are investigated. The results show that the broadcast ephemeris accuracy of the BDS-2 MEO satellite is the highest, while the GEO satellite broadcast ephemeris accuracy is the lowest. And their three-dimensional orbit difference is 3m and 7.5m, respectively. Second, the BDS-3 MEO satellite broadcast ephemeris accuracy is higher than the BDS-2, its three-dimensional orbit accuracy is about 0.39m, while its clock error is slightly smaller than the BDS-2. The result of ephemeris calculation is basically equivalent to the clock error of satellite-to-earth observation, which is related to the addition of the clock error of the inter-satellite link in the BDS-3. Finally, the clock error of the BDS-3 MEO satellite with the H clock is basically the same as that of the MEO satellite with the Rb clock.
Synthesis of optically inactive cellulose via cationic ring-opening polymerization
Authors: Ikegami Waki , Kamitakahara Hiroshi , Teramoto Yoshikuni , Takano Toshiyuki 
Published: April 2021

Abstract
Cellulose, which comprises D-glucose and L-glucose (D,L-cellulose), was synthesized from D-glucose (1D) and L-glucose (1L) via cationic ring-opening polymerization. Specifically, the ring-opening copolymerization of 3-O-benzyl-2,6-di-O-pivaloyl-β-D-glucopyranoside (2D) and 3-O-benzyl-2,6-di-O-pivaloyl-β-D-glucopyranoside (2L), synthesized from compounds 1D and 1L, respectively, in a 1:1 ratio, afforded 3-O-benzyl-2,6-di-O-β-D,L-glucopyranan (3DL) with a degree of polymerization (DPn) of 28.5 (Mw/Mn = 1.90) in quantitative yield. The deprotection of compound 3DL and subsequent acetylation proceeded smoothly to afford acetylated compound 4DL with a DPn of 18.6 (Mw/Mn = 2.08). The specific rotation of acetylated compound 4DL was + 0.01°, suggesting that acetylated compound 4DL was optically inactive cellulose triacetate. Furthermore, before acetylation, compound 4DL was an optically inactive cellulose comprising an almost racemic mixture of D-glucose and L-glucose. Compound 4DL was an amorphous polymer. This is the first reported synthesis of optically inactive D,L-cellulose.
Improving Understandability of Clinical Practice Guideline Recommendations: a Qualitative Study to Develop a Format for Pediatric Cancer Care
Authors: Santesso Nancy , Beauchemin Melissa , Robinson Paula D. , Walsh Alexandra M. , Sugalski Aaron J. , Lo Tammy , Dang Ha , Fisher Brian , Grimes Allison C. , Wrightson Andrea Rothfus , Yu Lolie C. , Sung Lillian , Dupuis L.Lee 
Published: April 2021

Abstract
Background: Features of clinical practice guideline (CPG) recommendations may affect understanding and consequently successful uptake and implementation. We aimed to develop a recommendation format to improve understandability among healthcare professionals involved in pediatric cancer care.Methods: We conducted a multi-center qualitative study of health care professionals at participating pediatric oncology sites. We developed an initial format based on the current literature and used the “think-aloud” technique in multiple rounds of one-on-one cognitive interviews to iteratively improve it. Interviews were conducted until the format was well understood and no new, substantive suggestions for revision were raised. We took a directed (deductive) approach to content analysis of the interview notes to identify concerns related to the understandability of the recommendation. Results: Five investigators interviewed 33 healthcare professionals from multiple disciplines in seven rounds. We identified important factors influencing how to communicate recommendations. Regarding the strength of the recommendation, participants found understanding weak recommendations more challenging than strong. Understanding was improved by using the word ‘conditional’ instead of ‘weak’. Participants believed the inclusion of a rationale section to be very helpful. More information was desirable when a recommendation entailed a practice change. Although participants wanted additional information, they were concerned that there could be too much information. They, therefore, suggested that key words and the studies included in the evidence synthesis be hyperlinked to explanatory data. In the final format, the recommendation strength is clearly indicated in the title, highlighted, and defined within a text box. The rationale for the recommendation is in a column on the left, with supporting evidence on the right. In a bulleted list, the rationale section describes the benefits and harms and additional factors, such as implementation, that were balanced by the CPG developers. Each bullet under the supporting evidence section indicates the level of evidence with an explanation and the supporting studies with hyperlinks when applicable. Conclusions: A well-understood recommendation format to present strong and conditional recommendations was created through an iterative interview process. The format is straightforward, making it easy for organizations and CPG developers to use it to communicate recommendations clearly to intended users.
Fast-track Versus Conventional Surgery in Relation to Time of Hospital Discharge Following Total Hip Arthroplasty: a Single-center Prospective Study.
Authors: Almeida Raul Frankllim de Carvalho , Serra Humberto Oliveira , de Oliveira Liszt Palmeira 
Published: April 2021

Abstract
Background: Total hip arthroplasty (THA) has been used for over five decades for treating hip osteoarthritis. THA is a surgical procedure associated with prolonged hospital length of stay (LOS). The aim of this study was to analyze whether a protocol developed for fast-track THA could decrease the time taken to reach functional recovery after surgery and the hospital LOS. Blood transfusion and critical care requirements and the complication rate were evaluated as secondary endpoints. Methods: Ninety-eight patients underwent THA at the University Hospital of the Federal University of Maranhão (São Luís, Brazil). The control group included 51 patients who underwent THA through the conventional method. The fast-track surgery (FTS) group included 47 patients who underwent THA through the FTS approach. The inclusion criteria were that the subjects needed to present hip osteoarthritis and at least one clinical indication for THA, and that their risk classification was in ASA category I or II. The following factors were evaluated: age, sex, diagnosis, laterality, type of arthroplasty, blood transfusion, critical care requirement, complications, LOS and need for re-hospitalization for any reason. For spinal anesthesia, an opioid-free protocol was used. Comparison of categorical variables between the groups was performed using the chi-square test, Shapiro-Wilk test, Student t test and Poisson regression approach.Results: The FTS and control groups were similar in age and sex distribution (p > 0.05). The majority of the patients in the control group required both blood transfusion and use of the critical care unit, thus differing from the patients who underwent FTS (p < 0.001). The mean hospital LOS in the FTS group was 2.3 ± 0.8 days, compared with 6.4 ± 1.5 days in the control group (p < 0.001).Conclusion: Use of FTS was associated with decreased LOS, compared with conventional THA.Trial registration: This research was approved by the institution’s ethics committee under the number 1,786,868.
Achieving Equitable Social Health Insurance Benefits in China: How Does Domestic Migration Pose a Challenge?
Authors: Hou Zhiyuan , Wang Haiqin , Liang Di , Zhang Donglan 
Published: April 2021

Abstract
Background: Universal coverage through social health insurance is promoted by many researchers and policymakers to improve health equity within a country or region. In China, the mass internal migration since 1980s has posed challenges for the social health insurance to ensure equitable benefits for migrant population. This study evaluated the benefit distribution of social health insurance among internal migrants in China.Methods: Using the 2014 China National Internal Migrants Dynamic Monitoring Survey, , by applying a two-part model, we conducted a benefit analysis of social health insurance among a representative sample of migrants in China.Results: The study found that the broader the geographic scope of migration, the lower the probability of receiving reimbursements from the social health insurance and the reimbursement ratio; but among those who received reimbursements, the broader the geographic scope of migration, the larger amounts they were reimbursed for health care use. We attributed this unequal benefit distribution to the current insurance design that replies on localized administration and patients paying services up-front and requesting reimbursement later.Conclusion: To improve the equity in social insurance benefits between migrants and non-migrants and among migrants, policies that promote the insurance portability across regions and immediate reimbursement are warranted, while at the same time efforts should be done to control inflation of health care expenditures and to prevent inverse government subsidies from the regions that have more out-migration to regions that have in-migration.
Impact of Nonpharmacological Public Health Interventions on Epidemiological Parameters of COVID-19 Pandemic in India
Authors: Kharya Pradip , Koparkar Anil Ramesh , Dixit Anand Mohan , Joshi Hari Shanker , Rath Rama Shankar 
Published: April 2021

Abstract
Public health interventions are epidemiologically sound cost-effective methods to control the disease burden. Non-pharmacological Interventions are the only mode to control the disease in the absence of medications. To find the impact interventions on the epidemiological indicators of disease progression. This is a secondary data analysis done on COVID-19 data. Median Doubling Time and R0 were calculated for a rolling period of seven days. Interventions were scored from zero to three with the increasing level of stringency. Multivariate linear regression was performed to find the role of individual interventions on R0 and Median Doubling Time. The highest intervention score was reported in the lockdown phase which gradually decreased to lowest level of 22. R0 values settled to a level of 1.25 and the median doubling time increased to 20 days at the end of the study. Public awareness and public health laws were found to be related to both R0 and median doubling time in the Pre-lockdown phase only. Implementation of interventions at the ground level is one of the key factors of the success of PHI. Post implementation poor effectiveness of many interventions is evident from the study. Further studies related to the sequence of interventions is required to further analyse the poor effect of interventions.
The Attitude of Polish Women Planning Pregnancy and Having Children Towards the Prevention Methods of Vertical Infections: a Cross-sectional Survey Study
Authors: Bieńkowski Carlo , Kowalczyk Monika Karolina , Golik Agata Alina , Kacperczyk-Bartnik Joanna , Bartnik Paweł , Dobrowolska-Redo Agnieszka , Romejko-Wolniewicz Ewa , Pokorska-Śpiewak Maria 
Published: April 2021

Abstract
BackgroundInfectious agents can cause serious fetopathy. Some of them can be avoided by implementing appropriate prevention methods while planning pregnancy.MethodsA cross-sectional survey study was performed. The questionnaire investigated attitudes towards the prevention methods of vertical infections. Opinions about anti-vaccine movements and “chicken-pox party” were also checked.ResultsThe study group consisted of 2402 women, age range was 16-54 years (median: 31 years). Most women were from cities > 100,000 inhabitants (49.7%, 1194/2402) and with higher education (71.9%, 1726/2402). Positive attitude towards vaccinations was more common among younger, nulliparous women from big cities (p=0.02, p=0.04 and p=0.01, respectively). 2068/2402 (86.1%) of them have not been vaccinated before pregnancy and 1931/2402 (80.4%) of women have not been vaccinated during pregnancy. 1545/2402 (64.3%) of women considered vaccination safe, and effective (1904/2402, 79.3%) against infectious diseases. Regarding the so-called chickenpox party as many n=296/2402 (12.3%) have no opinion on this matter.ConclusionsMost women in Poland have a positive attitude towards vaccination, they consider vaccines safe and effective against infectious diseases. A significant proportion of women have not been vaccinated, the role of physician leading the patient to be vaccinated is crucial. About 12% of women are the undecided fraction, and the educational role of physicians is essential to convince them of the importance of vaccination.
IL-1β and IL-1ra are key regulators of the inflammatory response to RNA vaccines
Authors: Mellman Ira , Tahtinen Siri , Tong Ann-Jay , Himmels Patricia , Oh Jaehak , Paler-Martinez Andres , Kim Leesun , Wichner Sara , Oei Yoko , McCarron Mark , Freund Emily , Amir Zhainib Adel , Cruz Cecile de la , Haley Benjamin , Blanchette Craig , Schartner Jill , Ye Weilan , Yadav Mahesh , Sahin Ugur , Delamarre Lelia 
Published: April 2021

Abstract
Excessive systemic inflammation is characteristic to various acute conditions including sepsis, viral infections and immunotherapy-induced adverse events such as cytokine release syndrome (CRS). Recently, several clinical trials evaluating variants of lipid-formulated RNA vaccines for either cancer or COVID-19 have reported systemic inflammatory responses that limit vaccine dosing in humans. Preclinical studies in inbred laboratory mice failed to predict these adverse events, suggesting the existence of underlying differences in sensitivity to Toll-like receptor (TLR) or other innate agonists between humans and mice. Here, we identify interleukin 1 receptor antagonist (IL-1ra) as an endogenous, inducible suppressor of systemic inflammation. In humans, stimulation with a TLR7/8 adjuvanted RNA-lipoplex (RNA-LPX) vaccine results in the secretion of inflammasome-activated interleukin-1β (IL-1β) by monocytes. Remarkably, IL-1β was found to control the induction of the broad spectrum of pro-inflammatory cytokines (including IL-6) associated with CRS. Unlike humans, murine leukocytes preferentially upregulate anti-inflammatory IL-1ra relative to IL-1β. IL-1ra deletion in mice leads to CRS-like symptoms, indicating that high levels of IL-1ra protect mice from uncontrolled systemic inflammation. Our results demonstrate that IL-1β and IL-1ra are key regulators that control systemic responses to RNA vaccines and other inflammatory stimuli. These data provide an explanation for the dramatic difference in dose-dependent tolerability between mice and humans and suggest an approach to evaluate pathogen-induced or immunotherapy-related inflammatory toxicities in vivo.
Oral health factors related to the quality of life in elderly urban residents of South-West Poland
Authors: Skośkiewicz-Malinowska Katarzyna , Kaczmarek Urszula , Malicka Barbara 
Published: April 2021

Abstract
BackgroundThe process of human body ageing is an inevitable phenomenon affecting all organs. Hence, the concept of Oral Health-Related Quality of Life (OHRQoL) was introduced, based on the definition of health developed by WHO. The study aimed to evaluate the impact of selected oral health parameters on oral health-related quality of life in elderly residents of South-West Poland.MethodsThe study involved 500 participants who were the citizens of South-West Poland aged 65 and more. There was an oral examination performed, including the assessment of coronal and root caries, periodontal disease, dental prosthetic status and xerostomia. The impact of oral health-related quality of life was measured using the Oral Health Impact Profile-14 (OHIP-14). Furthermore, socio-demographic questionnaires were obtained from participants. Logistic bivariate and multivariate regression analyses of dependent variables and independent variables were carried out as part of the study. ResultsThe mean value of DMFT was 27.5 ± 5.0. A higher number of DMF and extracted teeth resulted in increased values in all seven domains and exhibited a significant negative impact on the quality of life. Moreover, it enabled predicting values in individual domains of the OHIP-14 scale.ConclusionsThe number of missing teeth and teeth with caries constituted the predictors of poorer Oral Health-Related Quality of Life in all domains of the OHIP-14 scale. The impact of gingival bleeding on the quality of life was demonstrated. There was a decrease in the oral health-related quality of life in single individuals with several comorbidities and medications taken.