bluuebunny/crossref_metadata_2025_split huggingface dataset:
Annual Health Examination Didn’t Perform a Positive Effect in the Prevention of Hyperlipidemia and Hyperglycemia Through an Eightyear Study in China
Authors: zhang xiaohong , he xiaokui , zhou xuehong , geng hongyan , liu xiangyi 
Published: October 2021

Abstract
Background: Annual health examination is recommended for the prevention and treatment of cardiovascular diseases and diabetes. However, whether it is effective for the prevention of hyperlipidemia and hyperglycemia remains unclear. Methods: A retrospective analysis of clinical samples using the laboratory information system was performed. From 2012 to 2019, 5043 participants (1755 males and 3288 females) have completed the annual health examination for 8 consecutive years, which was the follow-up group. In the same period, 136,994 participants (the control group) had a health examination only 1 time. Serum levels of fasting triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and glucose (GLU) were measured.Results: Compared with 2019 of the control group, serum TC and GLU in the 8th year of the follow-up group increased markedly in some of age groups (p < 0.001). Serum TG and TC in the 8th year were much higher compared with the 1st year of the follow-up group, especially for the female (p < 0.001). Moreover, the prevalence of hyperlipidemia and hyperglycemia in the 8th year showed significant increase compared with the 1st year of the follow-up group and 2019 of the control group (all p < 0.05).Conclusions: Annual health examination didn’t perform a positive effect in the prevention of hyperlipidemia and hyperglycemia. Health management should be paid more attention to prevent cardiovascular disease and diabetes.
High diagnostic performance of a novel reverse transcription loop-mediated isothermal amplification (RT-LAMP) kit for the rapid detection of SARS-CoV-2
Authors: Domnich Alexander , Orsi Andrea , Panatto Donatella , De Pace Vanessa , Ricucci Valentina , Caligiuri Patrizia , Guarona Giulia , Chessa Valerio , Ferone Diego , Boccotti Simona , Bruzzone Bianca , Icardi Giancarlo 
Published: October 2021

Abstract
Although the reverse transcription polymerase chain reaction (RT-PCR) is considered a standard-of-care assay for the laboratory diagnosis of SARS-CoV-2, several limitations of this method have been described. Reverse transcription loop-mediated isothermal amplification (RT-LAMP) is an alternative molecular assay and is potentially able to overcome some intrinsic shortcomings of RT-PCR. In this study, we evaluated the diagnostic performance of the novel HG COVID-19 RT-LAMP assay. In this retrospective analysis, a total of 400 routinely collected leftover nasopharyngeal samples with a known RT-PCR result were tested by means of the HG COVID-19 RT-LAMP assay. The overall sensitivity and specificity values of HG COVID-19 RT-LAMP versus RT-PCR were 97.0% (95% CI: 93.6–98.9%) and 98.5% (95% CI: 95.7–99.7%), respectively. Inter-assay agreement was almost perfect (κ = 0.96). Concordance was perfect in samples with high viral loads (cycle threshold <30). The average time to a positive result on RT-LAMP was 17 min. HG COVID-19 RT-LAMP is a reliable molecular diagnostic kit for detecting SARS-CoV-2, and its performance is comparable to that of RT-PCR. Shorter turnaround times and the possibility of performing molecular diagnostics in the point-of-care setting make it a valuable option for facilities without sophisticated laboratory equipment.
Development and Preliminary Testing of a Decision aid to Support Hodgkin Lymphoma Survivors Considering Lung Cancer Screening
Authors: Broadbent Rachel , Seale Tania , Armitage Christopher J. , Linton Kim 
Published: October 2021

Abstract
BackgroundDecisions aids (DA) can support patients to make informed decisions about screening tests. This study describes the development and initial evaluation of a lung cancer screening (LCS) DA targeted towards survivors of Hodgkin lymphoma (HL).MethodsA prototype decision aid booklet was developed and subsequently reviewed by a steering group who provided feedback. Revisions were made to produce the DA tested in this study. HL survivors were recruited to an online survey and/or focus groups. Lymphoma practitioners were invited to an interview study. In the online survey, decisional conflict scales and knowledge scales were completed before and after accessing the DA. The focus groups and interviews explored acceptability and comprehensibility and the decisional needs of stakeholders. Focus groups and interviews were audio recorded. The framework method was used to analyse qualitative data. Results38 HL survivors completed the online survey. Following exposure to the DA, knowledge of LCS and risk factors and decisional conflict scores (total score and subscale scores) improved significantly. 11 HL survivors took part in two focus groups (n=5 and n=6) and 11 practitioners were interviewed. Focus group and interview results: The language, format and length were considered acceptable. Both groups felt the DA was balanced and presented a choice. Icon arrays were felt to aid comprehension of absolute risk values and for some survivors, they reduced affective risk perceptions. Among survivors, the impact of radiation risk on decision making varied according to gender and screening interval, whilst practitioners did not anticipate it to be a major concern for patients. Both groups expressed that a screening offer could mitigate anxiety about lung cancer risk. As anticipated by practitioners, survivors expressed a desire to seek advice from their clinical team. Practitioners thought the DA would meet their informational needs regarding lung cancer screening when supporting survivors. ConclusionsThe DA tested in this study is considered acceptable by HL survivors and their practitioners. The DA reduces decisional conflict and improves knowledge in HL survivors, suggesting that it would support HL survivors to make informed decisions when considering lung cancer screening in a future clinical trial.
Protocol for a scoping review study to identify occupational health hazards among healthcare providers and ancillary staff in Ghana
Authors: Tawiah Philip Apraku , Baffour-Awuah Alberta , Appiah-Brempong Emmanuel , Afriyie-Gyawu Evans 
Published: October 2021

Abstract
Introduction: The formation, modification and implementation of occupational health and safety policy for the Ghana health care industry hinges on data and reviews on occupational exposures. However, there is no synthesized review to speak to the issues of these occupational exposures. A scoping review on occupational exposures among the health workforce in Ghana will provide a broad overview of exposures, and can guide and assist in making decisions on occupational health issues relating healthcare workers. Methods: The Arksey and O’Malley’s scoping review methodology framework will guide the conduct of this scoping review. Primary research studies, government documents and other information on occupational exposures among healthcare workers published in English language will be retrieved from databases, including PubMed, CINAHL, Embase, Medline, Scopus, PsycINFO and Google scholar. Also, grey literature sources in Ghana including government and tertiary institutions websites will be searched. Reference list of key studies will also be screened to identify relevant studies for inclusion. The review will consider studies that address prevalence, knowledge and predisposing factors of occupational exposures along with utilization of occupational hazards preventive measures. After initial removal of duplicates, title and abstract screening, relevant articles will be subjected to full text analysis. The screening processes will be conducted independently by two reviewers. Data will then be extracted and presented in tabular form with a narrative to aid easy comprehension. Ethics and dissemination: This scoping review sought to identify predominant occupational exposures among healthcare providers and ancillary workers as described in published and unpublished literature. In addressing the increase of occupational exposures among healthcare workforce in Ghana, this scoping review is intended to bring all the literature together and predict the areas of occupational exposures that needs attention and redress. The findings of the study will be disseminated through publications, conference presentations and stakeholder meetings.
Analytical Methods for Assessing Retinal Cell Coupling Using Cut-Loading
Authors: Myles William E. , McFadden Sally Anne 
Published: October 2021

Abstract
Electrical coupling between retinal neurons contributes to the functional complexity of visual circuits. “Cut-loading” methods allow simultaneous assessment of cell-coupling between multiple retinal cell-types, but existing analysis impedes direct comparison with gold standard direct dye injection techniques. Therefore cut-loading was used to assess coupling strength in a-type horizontal cells in dark-adapted Guinea pig retinae (n=29) using the standard protocol (Method 1) compared with two non-linear methods. Method 1 describes the distance of dye-diffusion (space constant), while Method 2 extracted the coupling coefficient (kj) and Method 3 measured the diffusion coefficient (De). Dye transfer was measured after one of five diffusion times (1-20 mins), or with a coupling inhibitor, meclofenamic acid (MFA) (50–500µM after 20 mins diffusion). Method 1 includes background fluorescence, producing less accurate coupling estimates than measuring the fluorescence of individual cell-soma (p<0.001). The space constant (Method 1) increased with diffusion time (p<0.01), whereas Methods 2 (p=0.54) and 3 (p=0.63) produced consistent results across all diffusion times. Method 1 was less sensitive to detecting changes induced by MFA than Methods 2 (p<0.01) and 3 (p<0.01). Comparatively, Methods 2 and 3 proved more sensitive and generalisable; allowing for detailed assessment of the coupling between different populations of gap-junction linked cell networks.
The Mirror Reversal Mechanism on Black Hole Collapse and Singularity Eruption in Cosmic Continuum
Authors: Wang Xijia 
Published: October 2021

Abstract
In Cosmic continuum, the cosmic system collapse into a Schwarzschild black hole under the action of a strong gravitational field, and the Planck spheres at the center of the black hole continues to collapse into dark mass bodies, forming dark celestial body and singularity. The Schwarzschild radius is the upper limit of a black hole, and the Planck sphere is the lower limit of a black hole. The singularity is the conversion point between the old and new cosmic systems. The singularity erupts the Planck spheres under the action of a strong gravitational field, and the Planck spheres expands outward to form a new cosmic system. The Planck sphere is both the end of the old cosmic system and the starting point of the new cosmic system. The black hole collapse and the singularity eruption are mirror images of each other. The Planck sphere is the front of the mirror, and the singularity is the back of the mirror.
Hypocalcemia and Massive Pulmonary Embolism in SLE Patient with COVID-19 Infection, A Case Report
Authors: Yousif Mohammed Yousif Elnaeem , Eljack Moh.Mah.Fadel Allah , Alfatih Mohammed , Abdulkarim Mohammed , mohamed Abdirizak Ibrahim , Ahmed Khabab Abbasher Hussien Mohamed , Haroun Mazin Salah-Eldien Hassan 
Published: October 2021

Abstract
A 16-year-old female presented to our ED with fever and coughing of blood for 3 days. She is known to have SLE for 5 months and takes oral prednisone. She was tested positive for COVID19. She developed hypocalcemia with clinically-diagnosed massive pulmonary embolism. She was treated with heparin and recovered.
Study of Electrochromic (EC) and Gasochromic (GC) Glazing for Buildings in Aspect of Energy Efficiency
Authors: MARCHWIŃSKI Janusz 
Published: October 2021

Abstract
The paper analyzes the impact of switchable glazing: electrochromic (EC) and gasochromic (GC) on the energy efficiency of the building. Using the analytical and comparative method, the energy-relevant EC and GC glazing features were defined. Secondly, experimental studies on the energy-saving role of EC and GC glazing in various climatic zones were analyzed. The paper aims to define this role. The analyzes were referred to the thermal and lighting aspects. Comparisons were made between the EC and GC technologies, as well as with traditional - “static” types of glazing. The analysis showed differences in the technical characteristics of both technologies. Despite the differences, the results prove a beneficial effect of EC and GC glazing on the reduction of usable energy consumption in the building. The impact is most significant in terms of relieving the cooling and air conditioning systems. In this field, EC glazing was determined a more favorable technology. Further detailed research is required, focusing mainly on the lighting aspect for moderate and cold climate zones. The research was summarized with a collective evaluation of the energy-related role of EC and GC glazing.
Designing Convolutional Neural Network Architecture Using Genetic Algorithms
Authors: Bhandare Ashray , Kaur Devinder 
Published: October 2021

Abstract
In this paper, genetic algorithm (GA) is used to optimally determine the architecture of a convolutional neural network (CNN) that is used to classify handwritten numbers. The CNN is a class of deep feed-forward network, which have seen major success in the field of visual image analysis. During training, a good CNN architecture is capable of extracting complex features from the given training data; however, at present, there is no standard way to determine the architecture of a CNN. Domain knowledge and human expertise are required in order to design a CNN architecture. Typically architectures, The GA determine the exact architecture of a CNN by evolving the various hyper parameters of the architecture for a given application. The proposed method was tested on the MNIST dataset. The results show that the genetic algorithm is capable of generating successful CNN architectures. The proposed method performs the entire process of architecture generation without any human intervention.
Research on ISPs Selection Technology Based on Network Quality Monitoring
Authors: Wang Jian , Wang Zhongsheng 
Published: October 2021

Abstract
With the development of the network era, ISP have become more than one. Users can choose ISP according to personal preference when buying broadband, to provide users with the right to choose. However, with the improvement of network speed and bandwidth, people still feel the network congestion during peak hours. In this paper, users can choose different ISPs dynamically based on network quality monitoring. In this paper, the HTTP protocol of the application layer is used to accurately measure the real Internet situation of users, and the PC is used to actively send data to two network links at the same time, and finally the feedback parameter information can be obtained. According to this protocol, the real loading time of data can be accurately measured and the optimal ISP link can be selected. Then, a one-to-one relationship between the client address and different ISPs is established, and this relationship is saved in the routing table. Users will dynamically choose different ISPs by using the network address translation.
In-situ pumping tests and numerical simulations of seepage wells in the Yellow River valley, China
Authors: Ke Xianmin , Wang Wei , Li Jinlong , Sun Qiming , Lian Lulu , Xu Xiangdong , Lyu Qiaofen 
Published: October 2021

Abstract
Seepage wells that can convert surface water into groundwater are often constructed near river valleys to obtain more water and lead to smaller drawdown compared with traditional wells. Seepage wells have been widely used, whilst the groundwater and river-level variations caused by seepage wells are still unclear, and numerical models are rarely verified due to the lack of in-situ observational data, which may lead to results that are quite different from the actual conditions. To address those limitations, a large-scale pumping test was carried out near the Yellow River valley in China and a coupled seepage–pipe flow model was established using the exchange yield between the aquifer and pipe as the coupling key in this research. The coupled model was evaluated with in-situ measurement. The field observation showed that both the river and groundwater had a positive response to the pumping of the seepage wells. The simulation results indicated that our model can well estimate the pumping rate and drawdown with root-mean-square deviations of 158.235 m3/d and 0.766 m, respectively. Further, it is also found that the groundwater showed the obvious characteristics of three-dimensional flow under the influence of seepage wells and the maximum drawdown should be less than 15 m to ensure exploitation efficiency. These findings provide important information that can guide the design and construction of seepage wells to improve the rational exploitation of groundwater.
Multicomponent Reactions in the Synthesis of Antiviral Compounds
Authors: Botta Lorenzo , Cesarini Silvia , Zippilli Claudio , Bizzarri Bruno Mattia , Fanelli Angelica , Saladino Raffaele 
Published: October 2021

Background:Multicomponent reactions are one-pot processes for the synthesis of highly functionalized hetero-cyclic and hetero-acyclic compounds, often endowed with biological activity.Objective:Multicomponent reactions are considered green processes with a high atom economy. In addition, they present advantages compared to the classic synthetic methods, such as high efficiency and low waste production.Methods:In these reactions, two or more reagents are combined together in the same flask to yield a product containing almost all the atoms of the starting materials.Results:The scope of this review is to present an overview of the application of multicomponent reactions in the synthesis of compounds endowed with antiviral activity. The syntheses are classified depending on the viral target.Conclusion:Multicomponent reactions can be applied to all the stages of the drug discovery and development process, making them very useful in the search for new agents active against emerging (viral) pathogens.
Organic- or Inorganic-based Nanomaterials: Opportunities and Challenges in the Selection for Biomedicines
Authors: Kankala Ranjith K. 
Published: October 2021

:
Since the inception of nanotechnology, several efforts have been dedicated to fabricating diverse
nanodevices with exceptional performance. These innovative constructs have been applied in medicine due to
their tailorable physicochemical properties (chemical composition, optical activity, spectra, and charge) and
morphological attributes (size, shape, and surface area). Moreover, these versatile nanomedicines could
promisingly offer better performance over the conventional therapeutic strategies. Broadly speaking, in terms of
chemical composition, nanobiomaterials are classified into two predominant categories of organic and inorganic-
based components. Despite their success and enormous versatile advancements in the past two decades, the
significant progress towards clinical translation has been hampered by their corresponding intrinsic limitations.
In this perspective, we give a brief overview of these organic- and inorganic-based materials, highlighting opportunities
and challenges towards their utilization in medicine. Finally, we provide an interesting outlook on
the lessons learned and look forward to further developing these materials, emphasizing their potential in clinical
translation.
Alkaloids Exhibit a Meaningful Function as Anticancer Agents by Restraining Cellular Signaling Pathways
Authors: Guo Chong , Yuan Chengfu , Xu Wen , Wang Bei , Gao Yisong , Cai Yuxuan , Zhang Jiali , Wu Zhiyin , Wei Jiameng 
Published: October 2021

Abstract:
Alkaloids are nitrogen-containing organic compounds widely found in natural products, which play an essential role in clinical treatment. Cellular signaling pathways in tumors are a series of enzymatic reaction pathways that convert extracellular signals into intracellular signals to produce biological effects. The ordered function of cell signaling pathways is essential for tumor cell proliferation, differentiation, and programmed death. This review describes the antitumor progression mediated by various alkaloids after inhibiting classical signaling pathways; related studies are systematically retrieved and collected through PubMed. We selected the four currently most popular pathways for discussion and introduced the molecular mechanisms mediated by alkaloids in different signaling pathways, including the NF-kB signaling pathway, PI3K/AKT signaling pathway, MAPK signaling pathway, and P53 signaling pathway. The research progress of alkaloids related to tumor signal transduction pathwa
Triazole as Potent Anti-cancer Agent- A Pharmacophoric Scaffold
Authors: Kala Nidhi , Rahate Kalpana Praveen 
Published: October 2021

:
Triazole is the main five-membered Nitrogen-containing basic heterocyclic ring system
reported for their biological activities and compounds with multiple pharmacophores, which fetch
together acquaintance of a target with sympathetic types of the molecule that might interact with
the target. In addition, healthy, adaptable, and scalable chemistry must be employed to achieve the
task. This characteristic feature of triazole would make a good template for a lead cohort library.
The current review article focuses on recent advancements in triazole moiety as an anti-cancer
agent with their mechanism pathways of synthesized analogues.
Evaluation of Maternal and Infantile Levels of Vitamin D in Preterm Infants
Authors: Boskabadi Hassan , Moradi Ali , Zakerihamidi Maryam 
Published: October 2021

Introduction:
Vitamin D deficiency is highly prevalent during pregnancy and in premature
infants. This study was done to investigate the maternal and infantile levels of vitamin D in
preterm infants.

Methods:
Using available sampling during 2018-2020, the maternal and umbilical cord serum levels
of vitamin D were measured in 294 premature infants in Ghaem Hospital, Mashhad, Iran. A researcher-
made questionnaire consisting of neonatal demographic and clinical characteristics was
used as the data collection tool. Both maternal and placental vitamin D levels were categorized into
four classes: severe deficiency (vitamin D<10 ng/ml), moderate deficiency (10.1≤vitamin D≤20
ng/ml), mild deficiency (20.1≤vitamin D≤30 ng/ml) and normal (vitamin D >30.1ng ml).

Results:
Vitamin D deficiency was seen in 89% of premature infants (46.6% severe, 30.6% moderate,
and 11.9% mild). Serum levels of vitamin D were 18.28±13.94 ng/ml and 14.10±9.70 ng/ml in
mothers and infants, respectively. The infants below and above 32 weeks exhibited vitamin D values
of 10.97±6.31 ng/ml and 18.05±11.64 ng/ml, respectively. The difference in vitamin D levels
between boys (12.59±8.40 ng/ml) and girls (16.05±11.45 ng/ml) was found to be significant
(P=0.009). Moderate and severe vitamin D deficiency was more common at earlier pregnancy ages
(P=0.001).

Conclusion:
Vitamin D deficiency is more common and severe in preterm infants and their
mothers. Controlling vitamin D levels during pregnancy, especially in women at risk of preterm labor
and preterm infants, may help reduce prematurity problems.