bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical load for buckling of solid wood elements with a high slenderness ratio determined based on elastica theory
Authors: Yoshihara Hiroshi , Maruta Makoto 
Published: December 2021

Abstract
Buckling tests were conducted using slender specimens of western hemlock. In the tests, the slenderness ratio was varied from 132 to 418 in which elastic buckling was induced, and the values of the critical load for buckling were obtained. When the deflection of the specimen was calculated from the loading-line displacement based on elastica theory, the value of deflection/load initially decreased because the compressive deformation was more dominant than the bending deformation. In contrast, when the load increased, the bending deformation became dominant, and the deflection/load-deflection relation exhibited linearity. These tendencies indicated that the transition from compression to bending was induced around the minimum value of the deflection/load. Therefore, it was recommended to determine the critical load for buckling using the load at the minimum value of the deflection/load where the deflection was calculated from the loading-line displacement.
Effects of regular and joke dog whistles on perceptions of political candidates
Authors: Prokhorets Svyatoslav “Slava” , Saucier Donald A. 
Published: December 2021

AbstractOur experiment showed a scenario where a White politician used a racist dog whistle (DW) when referring to his Black opponent. We used pilot data to determine DW statements and then tested whether different DWs (joke or regular) would affect perceptions of candidates based on participants’ levels of subtle and explicit racism compared to a comment without racial undertones. Our results indicated that while neither DW affected perceptions of the Black candidate based on participants’ levels of subtle racism, when a regular DW was used, subtle racism was positively associated with more positive perceptions of the White candidate. Our findings can broadly be explained within the context of modern racism and the suppression justification model of prejudice. The presence of a DW served as a prime, allowing those who have subtle anti-Black prejudice to express it through more positive personal perceptions of the White candidate. Without opportunities to justify the expression of their subtle prejudice (i.e. have a non-prejudice reason to dislike the candidate), the participants’ did not report more negative perceptions of the Black candidate. However, there was a “backlash” and participants were less likely to consider voting for the White candidate, particularly when he used a joke DW.
Photocatalytic degradation of acetaminophen from water solutions via thin films part I: preparation, characteriation, and analysis of titanium dioxide thin films
Authors: Rawal Sunil , Buer Sabrina H. , Hawkins Wayne , Sanders Jonathan Robby , Arce Pedro E. 
Published: December 2021

Abstract
The utilization of titanium dioxide (TiO2) photocatalysis for water and air purification is a frequently used method due to TiO2 having properties making it chemically inert, highly cost-effective, abundant, non-toxic, and environmentally-friendly. In an effort to increase the efficiency of the degradation process, an in-depth understanding of the effects of the structure and number of thin film coatings is needed. Transparent, anatase-form titanium dioxide thin films were prepared via the sol-gel method and deposited onto microscopic glass slides using a novel spraying technique, with coatings ranging from 1 to 10. Characterization of the TiO2 thin film coated slides was performed using X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques. The contribution shows that the coating technique is efficient in covering important areas of the surface and that it is suitable for a multiple coating layers thin film. The SEM imagines show that the surface of the slides increase coverage as the number of layers increases. This is potentially suitable for a mechanized spraying approach to upscaling the production of thin films for advanced oxidation applications.
Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
Authors: Arzoo Subiah Helal , Chattopadhyay Krishna , Parvin Tania , Chattopadhyay Brajadulal 
Published: December 2021

Abstract

Objectives
Inflammation, insulin resistance, hyperinsulinemia and cell damage are the major patho-physiological reasons behind type 2 diabetes (T2DM), which is one of the most prevalent non communicable metabolic disorders in the world. Oral hypoglycemic drugs and insulin shots are usually exercised to treat the diabetic patients but it produces many side effects. Thereby paving the way for natural hypoglycemic agents; a Himalayan herb and alternative nutritional therapy; low glycaemic indexed pumpkin seed, are used in combination for a better management of the disease. The aim of the study was to explore the combined efficacy of Gymnadenia orchidis Lindl root Salep and low-glycemic indexed-pumpkin seeds in better management of T2DM and associated complications.

Methods
Balb/c mice were randomly allocated to six different groups (n=5). Streptozotocin along with high-fat-diet was used to induce T2DM. The experimental animals were supplemented with low-glycemic food or root Salep (200 mg/kg body weight) or combination of both according to their groups for 21 days, post which various biochemical tests were performed.

Results
T2DM augmented the IL-6, IFN-γ, TNF-α, BAX, Insulin levels, and HOMA-IR with concurrent reduction of IL-4, QUICKI, Bcl-2, estradiol and progesterone levels. FACS revealed augmented cellular damage in T2DM mice. Interestingly, root Salep and pumpkin seeds normalized those parameters in T2DM animals suggesting significant (p<0.001) improvement of immunity of the diseased animals and ameliorated associated complications.

Conclusions
Root Salep and pumpkin seed display synergism among binomial set of herbal agents which may be safely used for T2DM management.
Niemann–Pick type C disease with a novel intronic mutation: three Turkish cases from the same family
Authors: Kılıç Yıldırım Gonca , Yarar Coşkun , Şeker Yılmaz Berna , Ceylaner Serdar 
Published: December 2021

Abstract

Objectives
Niemann–Pick type C (NPC) disease is a rare progressive neurodegenerative condition that is characterized by the accumulation of cholesterol, glycosphingolipids, and sphingosine in lysosomes. Patients have various systemic and neurological findings depending on their age at onset. This disease is caused by the autosomal recessive transmission of mutations in the NPC1 and NPC2 genes; patients have mutations mainly in the NPC1 gene (95%) and the majority of them are point mutations located in the exonic regions.

Case presentation
Here, we presented three cousins with hepatosplenomegaly and progressive neurodegeneration who were diagnosed with visceral-neurodegenerative NPC disease. Their parents were relatives, and they had a history of sibling death with similar complaints. Bone marrow smear showed foamy cells in patient 1. Vertical supranuclear gaze palsy was not present in all cases. Sphingomyelinase (SM) activities were almost normal to exclude NPA or NPB. Filipin staining was performed in patient 2 and showed a massive accumulation of unesterified cholesterol The NPC1 gene analysis of the three patients showed a novel homozygous c.1553+5G>A intronic mutation. cDNA analysis was performed from the patient 3 and both parents. It was observed that exon 9 was completely skipped in the homozygous mutant baby. Both the normal and the exon 9-skipped transcripts have been detected in the parents.

Conclusions
When combined with the filipin staining and the patients’ clinical outcomes, this mutation is likely to be deleterious. Moreover, cDNA sequencing supports the pathogenicity of this novel variant.
Three novel mutations of the BCKDHA, BCKDHB and DBT genes in Chinese children with maple syrup urine disease
Authors: Yang Jianmei , Xiu Jianjun , Sun Yan , Liu Fan , Shang Xiaohong , Li Guimei 
Published: December 2021

Abstract

Background
Maple syrup urine disease (MSUD) is a rare metabolic autosomal recessive disorder caused by deficiency of the branched-chain α-ketoacid dehydrogenase complex. Mutations in the BCKDHA, BCKDHB and DBT genes are responsible for MSUD. This study presents the clinical and molecular characterizations of four MSUD patients.

Methods
Clinical data of patients were retrospectively analyzed, and genetic mutations were identified by whole-exome sequencing. CLUSTALX was employed to analyzed cross-species conservation of the mutant amino acid. The impact of the mutations was analyzed with PolyPhen-2 software. The I-TASSER website and PyMOL software were used to predict the protein three-position structure of the novel mutations carried by the patients.

Results
Vomiting, irritability, feeding difficulties, seizures, dyspnoea, lethargy and coma were the main clinical presentations of MSUD. Cranial MRI showed abnormal symmetrical signals in accordance with the presentation of inherited metabolic encephalopathy. Seven mutations were detected in four patients, including three novel pathogenic mutations in the BCKDHA (c.656C>A), BCKDHB (deletion of a single-copy of BCKDHB) and DBT (c.1219dup) genes. Structural changes were compatible with the observed phenotypes.

Conclusions
Different types of MSUD can display heterogeneous clinical manifestations. Exhaustive molecular studies are necessary for a proper differential diagnosis. The newly identified mutation will play a key role in the prenatal diagnosis of MSUD in the future.
Bacterial DNA detection in very preterm infants assessed for risk of early onset sepsis
Authors: Straňák Zbyněk , Berka Ivan , Korček Peter , Urbánek Jan , Lázničková Táňa , Staněk Libor 
Published: December 2021

Abstract

Objectives
The aim of this study is to evaluate the diagnostic ability of multiplex real-time polymerase chain reaction (PCR) in very preterm infants assessed for risk of early onset neonatal sepsis (EOS).

Methods
Prospective observational cohort study. Blood samples of preterm neonates ≤32 weeks of gestation were evaluated by commercial multiplex real-time PCR within 2 h after delivery. The definition of EOS was based on positive blood culture and clinical signs of infection or negative blood culture, clinical signs of infection and abnormal neonatal blood count and serum biomarkers.

Results
Among 82 subjects analyzed in the study, 15 had clinical or confirmed EOS. PCR was positive in four of these infants (including the only one with a positive blood culture), as well as in 15 of the 67 infants without sepsis (sensitivity 27%, specificity 78%). Out of 19 PCR positive subjects, Escherichia coli was detected in 12 infants (63%). Statistically significant association was found between vaginal E. coli colonization of the mother and E. coli PCR positivity of the neonate (p=0.001). No relationship was found between neonatal E. coli swab results and assessment findings of bacterial DNA in neonatal blood stream.

Conclusions
Multiplex real-time PCR had insufficient diagnostic capability for EOS in high risk very preterm infants. The study revealed no significant association between PCR results and the diagnosis of clinical EOS. Correlation between maternal vaginal swab results and positive PCR in the newborn needs further investigation to fully understand the role of bacterial DNA analysis in preterm infants.
Spatial dynamics of fetal mortality and the relationship with social vulnerability
Authors: Silva Myllena O. , Macedo Vilma C. , Canuto Indianara M.B. , Silva Mayara C. , da Costa Heitor V.V. , do Bonfim Cristine V. 
Published: December 2021

Abstract

Objectives
To analyze the spatial-temporal patterns of fetal mortality according to its relationship with social vulnerability, identifying priority areas for intervention.

Methods
Ecological study conducted in the state of Pernambuco, Northeast region of Brazil, from 2011 to 2018. The mean fetal mortality rate per city was calculated for the studied period. A cluster analysis was performed to select cities with homogeneous characteristics regarding fetal mortality and social vulnerability, then the Attribute Weighting Algorithm and Pearson correlation techniques were employed. In the spatial analysis it was used the local empirical Bayesian modeling and global and local Moran statistics.

Results
Twelve thousand nine hundred and twelve thousand fetal deaths were registered. The fetal mortality rate for the period was 11.44 fetal deaths per 1,000 births. The number of groups formed was 7, in which correlation was identified between fetal mortality and dimensions, highlighting the correlations between fetal mortality rate and the Index of Social Vulnerability urban infrastructure for the municipalities in group 1 and 5, the values of the correlations found were 0.478 and 0.674 respectively. The spatial analysis identified areas of higher risk for fetal mortality distributed in regions of medium, high and very high social vulnerability.

Conclusions
The study allowed observing the existing correlations between fetal mortality and social vulnerability and identifying priority areas for intervention, with a view to reducing fetal mortality in the state.
The Unsung Buber-Leibowitz Coda to the German Jewish Swan Song
Authors: Rubinstein Dana , Wygoda Ynon 
Published: December 2021

Abstract
Among the hidden treasures squirreled away in the archives of Israel’s National Library lies a fragmented correspondence that sheds new light on the afterlife of a project that was long deemed the farewell gift to the German language and culture from the remnants of its Jewry. It is an exchange of letters between two scholars, whose interest in the German rendition of the Bible occupied them for many years, first in Germany, and later in the land where Hebrew was vernacular and where one might think there would no longer be a need for translations of the Bible; particularly not into a language that aroused considerable aversion in the aftermath of the war. And yet, the 1963–64 exchange between the two Jerusalemites, the Vienna-born and Frankfurt-crowned philosopher, theologian, and translator Martin Buber and the Riga-born, Berlin- and Marburg-educated biblical scholar Nechama Leibowitz tells a different story. It shows they both believed the project that began under the title Die Schrift, zu verdeutschen unternommen should be revised once again, after its completion so as to underline its ongoing relevance for present and future readings of the Bible tout court, in German and Hebrew speaking lands alike.
Quasi-BIC laser enabled by high-contrast grating resonator for gas detection
Authors: Zhang Haoran , Wang Tao , Tian Jingyi , Sun Jiacheng , Li Shaoxian , De Leon Israel , Zaccaria Remo Proietti , Peng Liang , Gao Fei , Lin Xiao , Chen Hongsheng , Wang Gaofeng 
Published: December 2021

Abstract
In this work, we propose and numerically investigate a two-dimensional microlaser based on the concept of bound states in the continuum (BIC). The device consists of a thin gain layer (Rhodamine 6G dye-doped silica) sandwiched between two high-contrast-grating layers. The structure supports various BIC modes upon a proper choice of topological parameters; in particular it supports a high-Q quasi-BIC mode when partially breaking a bound state in the continuum at Γ point. The optically-pumped gain medium provides sufficient optical gain to compensate the quasi-BIC mode losses, enabling lasing with ultra-low pump threshold (fluence of 17 μJ/cm2) and very narrow optical linewidth in the visible range. This innovative device displays distinguished sensing performance for gas detection, and the emission wavelength sensitively shifts to the longer wavelength with the changing of environment refractive index (in order of 5 × 10−4). The achieved bulk sensitivity is 221 nm/RIU with a high signal to noise ratio, and a record-high figure of merit reaches to 4420 RIU−1. This ultracompact and low threshold quasi-BIC laser facilitated by the ultra-narrow resonance can serve as formidable candidate for on-chip gas sensor.
Structuring and functionalization of non-metallic materials using direct laser interference patterning: a review
Authors: Mulko Lucinda , Soldera Marcos , Lasagni Andrés Fabián 
Published: December 2021

AbstractDirect laser interference patterning (DLIP) is a laser-based surface structuring method that stands out for its high throughput, flexibility and resolution for laboratory and industrial manufacturing. This top–down technique relies on the formation of an interference pattern by overlapping multiple laser beams onto the sample surface and thus producing a periodic texture by melting and/or ablating the material. Driven by the large industrial sectors, DLIP has been extensively used in the last decades to functionalize metallic surfaces, such as steel, aluminium, copper or nickel. Even so, DLIP processing of non-metallic materials has been gaining popularity in promising fields such as photonics, optoelectronics, nanotechnology and biomedicine. This review aims to comprehensively collect the main findings of DLIP structuring of polymers, ceramics, composites, semiconductors and other non-metals and outline their most relevant results. This contribution also presents the mechanisms by which laser radiation interacts with non-metallic materials in the DLIP process and summarizes the developed surface functions and their applications in different fields.
Flat telescope based on an all-dielectric metasurface doublet enabling polarization-controllable enhanced beam steering
Authors: Li Hongliang , Zhou Changyi , Lee Woo-Bin , Choi Duk-Yong , Lee Sang-Shin 
Published: December 2021

Abstract
A flat telescope (FTS), which incorporates an all-dielectric metasurface doublet (MD) based on hydrogenated amorphous silicon nanoposts, is proposed and demonstrated to achieve flexibly magnified angular beam steering that is sensitive to both light polarization and deflection direction. Specifically, for transverse-electric-polarized incident beams, the MD exhibits deflection magnification factors of +5 and +2, while for transverse magnetic polarization, the beam is steered in reverse to yield magnification factors of −5 and −2 in the horizontal and vertical directions, respectively. The proposed MD comprises cascaded metalenses, which can invoke polarization-selective transmission phases. The MD which emulates a set of convex and concave lenses renders positively increased beam deflection, whereas the case corresponding to a pair of convex lenses facilitates negatively amplified beam deflection. The essential phase profiles required for embodying the MD are efficiently extracted from its geometric lens counterpart. Furthermore, the implemented FTS, operating in the vicinity of a 1550 nm wavelength, can successfully enable enhanced beam steering by facilitating polarization-sensitive bidirectional deflection amplifications. The proposed FTS can be applied in the development of a miniaturized light detection and ranging system, where the beam scanning range can be effectively expanded in two dimensions.
Evaluation of fines separation from unbleached softwood kraft pulp using microperforated hole screens
Authors: Mandlez D. , Eckhart R. , Bauer W. 
Published: December 2021

AbstractThe application of a bench scale and an industrial scale pressure screen to separate cellulosic fines from an unbleached softwood kraft pulp containing 5 % (w/w) primary fines was investigated and the results were compared. In the bench scale trials different microperforated screens with hole diameters of 150 µm, 250 µm, 400 µm and 600 µm were used. Based on these results a screen hole diameter of 400 µm was selected for the industrial scale trials. In all cases, a high accept flow rate proved to be the crucial parameter for high removal efficiency of the fines material and a removal efficiency of well above 50 % could be achieved. Further of interest were the limiting factors regarding increased accept flow rates with a focus on the interrelations between pressure difference, slot velocity and reject consistency. As expected, investigation of electric energy demand showed a correlation between removal efficiency and specific energy consumption, which did not exceed 35 kWh/t(od) feed.
Dynamic crystallization behavior of PA-12/PP-MWCNT nanocomposites: non-isothermal kinetics approach
Authors: Sethy Sucharita , Samantaray Saroj Kumar , Satapathy Bhabani K. 
Published: December 2021

Abstract
The effect of multi-walled carbon nanotubes (MWCNT) loading on the crystallization behavior of matrix polyamide 12 (PA-12), in PA-12/polypropylene-MWCNT (PP-MWCNT)-based nanocomposites were analyzed for their non-isothermal crystallization behavior at various cooling rates of 2.5–20 °C/min in differential scanning calorimetry (DSC). Several kinetic models such as Jeziorny (modified-Avrami), Mo and Tobin models were employed to analyze the crystallization behavioral trend with respect to time and temperature of the nanocomposites. The crystallization rate increased half-time of crystallization with MWCNT content as estimated from the Jeziorny theory. The linear agreement between Jeziorny model and experimental relative crystallinity outperforms the Tobin analysis where the coefficient of linear regression was found to be considerably trailing behind and off the satisfactory mark. The Mo model accounts for the percentage crystallinity and thereby successfully explained the crystallization behavior of PA-12 where the kinetic parameters increased with crystallinity indicating higher cooling rate for higher crystallinity. The MWCNT induced crystallization (nucleation activity) values were close to zero irrespective of MWCNT loading which reiterates the enhanced crystallization (rate) of PA-12 in the nanocomposites. Estimations based on Friedman approach showed inter-relationship between activation energy and crystallinity where the later was found to be governed by major (matrix) PA-12 phase.
“Failing kidneys in a failing planet; CKD of unknown origin”
Authors: Geladari Eleni , Vallianou Natalia , Geladari Charalampia , Aronis Konstantinos , Vlachos Konstantinos , Andreadis Emmanuel , Theocharopoulos Ioannis , Dourakis Spyros 
Published: December 2021

Abstract
The ‘alarm clock’ for human beings in the era of climate medicine has rung. Original diseases have appeared, that could not be explained and attributed to common causes, which are suggested to be linked to global warming and environmental factors. Such an indolent disease is the chronic kidney disease of unknown cause (CKDu), introduced also as Mesoamerican or Uddanam nephropathy. Scientists equate the climate impact on kidneys with the canary in the coal mine; coal miners used to carry caged canaries with them, so that if poisonous gases, such as methane or carbon monoxide leaked into the mine-shaft, the gases would kill the canary before killing the miners; similarly, kidneys are injured before devastating and lethal complications occur in humans. In some regions of Central America, the deaths due to chronic kidney disease increased by 177% with a death toll being as high as over 20,000. It was first documented in animals that periodic heat and dehydration have a major role in causing chronic kidney disease. Based on that observation, it is advocated that young male agricultural workers in Central America and South Asia, develop renal disease by getting exposed to extreme heat repeatedly. The clinico-pathological characteristics of this type of kidney injury, do not belong to an existing classification, even though a form of tubulo-interstitial renal disease has been proposed. In this review, we will discuss about CKDu, its epidemiology and pathophysiological mechanisms, clinical presentation and diagnostic biomarkers and examine potential therapeutic options.