bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features of congenital complete vaginal atresia combined with cervical aplasia: A retrospective study of 19 patients and literature review
Authors: Mei Ling , Zhang Heng , Chen Yueyue , Niu Xiaoyu 
Published: April 2021

AbstractCongenital vaginal atresia is a rare congenital reproductive tract abnormality. To assess the clinical manifestations and feasibility of preserving uterus for congenital complete vaginal atresia with cervical aplasia, nineteen cases who underwent surgical treatment in West China Second Hospital of Sichuan University were retrospectively studied. The cervical status, clinical manifestations, the rate of vaginal re‐stenosis and pelvic inflammation after surgery were assessed. Additional 101 similar cases searched through digital Pub Med were included to analyze the feasibility of preserving the uterus. Periodic abdominal pain, primary amenorrhea, and pelvic mass were the primary signs and symptoms. According to the magnetic resonance imaging (MRI), all the uterine cavities expanded, and the atresia sites were above the inner urethral orifice. Data of the cases preserving uteri from both our hospital and the literature showed the rate of re‐stenosis in patients with external cervical obstruction was 15.9% while it was 40% in the other types of cervical aplasia (P = .026). The rate of recurrent pelvic inflammation and hysterectomy was 2.3% for cervical external os obstruction and 8% for the other cervical aplasia types(P = .296). In conclusion, vaginoplasty and cervicovaginal anastomosis could preserve the fertility for complete vaginal atresia with cervical external os obstruction.
Analyzing the Museum Experience Through the Lens of Instagram Posts
Authors: Rhee Bo‐A , Pianzola Federico , Choi Gang‐Ta 
Published: April 2021

AbstractThe purpose of this study is to examine visitors’ Instagram posts through a combination of quantitative methods to cast light on museum experiences. To analyze a large quantity of Instagram data, we used computer vision and semantic analysis. The results of hashtag analysis showed that informative hashtags were the most prominent for all museums. It is notable that the geo‐related hashtags, such as exhibition venue and local information, accounted for a significant portion of the total data. Little to no evidence of viewing experience or emotional response can be derived from the results of hashtag analysis. In the image analysis of Instagram post, art exhibition, artifact and architecture were dominant, but the space within and around museums is also relevant. Thus, Instagram images can be an important component for understanding what is occurring within and around the museum when people move to take photographs and share these experiences on Instagram. This research offers a method for image analysis easily replicable by museums and insight about how to interpret the results for planning activities of audience development.
Incidence of sight‐threatening diabetic retinopathy in an established urban screening programme: An 11‐year cohort study
Authors: Cheyne Christopher P. , Burgess Philip I. , Broadbent Deborah M. , García‐Fiñana Marta , Stratton Irene M , Criddle Ticiana , Wang Amu , Alshukri Ayesh , Rahni Mehrdad M. , Vazquez‐Arango Pilar , Vora Jiten P. , Harding Simon P. ,   ISDR Study Group
Published: April 2021

AbstractAimsSystematic annual screening to detect sight‐threatening diabetic retinopathy (STDR) is established in the United Kingdom. We designed an observational cohort study to provide up‐to‐date data for policy makers and clinical researchers on incidence of key screening endpoints in people with diabetes attending one screening programme running for over 30 years.MethodsAll people with diabetes aged ≥12 years registered with general practices in the Liverpool health district were offered inclusion. Data sources comprised: primary care (demographics, systemic risk factors), Liverpool Diabetes Eye Screening Programme (retinopathy grading), Hospital Eye Services (slit lamp biomicroscopy assessment of screen positives).Results133,366 screening episodes occurred in 28,384 people over 11 years. Overall incidences were: screen positive 6.7% (95% CI 6.5–6.8), screen positive for retinopathy 3.1% (3.0–3.1), unassessable images 2.6% (2.5–2.7), other significant eye diseases 1.0% (1.0–1.1). 1.6% (1.6–1.7) had sight‐threatening retinopathy confirmed by slit lamp biomicroscopy. The annual incidence of screen positive and screen positive for retinopathy showed consistent declines from 8.8%–10.6% and 4.4%–4.6% in 2007/09 to 4.4%–6.8% and 2.3%–2.9% in 2013/17, respectively. Rates of STDR (true positive) were consistently below 2% after 2008/09. Screen positive rates were higher in first time attenders (9.9% [9.4–10.2] vs. 6.1% [6.0–6.2]) in part due to ungradeable images (4.1% vs. 2.3%) and other eye disease (2.4% vs. 0.8%). 4.5% (3.9–5.2) of previous non‐attenders had sight‐threatening retinopathy. Compared with people with type 2 diabetes, those with type 1 disease demonstrated higher rates of screen positive (11.9% vs. 6.0%) and STDR (6.4% vs. 1.2%). Overall prevalence of any retinopathy was 27.2% (27.0–27.4).ConclusionsIn an established screening programme with a stable population screen, positive rates show a consistent fall over time to a low level. Of those who are screen positive, fewer than 50% are screen positive for diabetic retinopathy. Most are due to sight threatening maculopathy. The annual incidence of STDR is under 2% suggesting future work on redefining screen positive and supporting extended intervals for people at low risk. Higher rates of screen positive and STDR are seen in first time attenders. Those who have never attended for screening should be specifically targeted.
Trends in the use of antihistamines with reference to drivers between 2015 and 2019: A population‐based registry analysis
Authors: Gutiérrez‐Abejón Eduardo , Herrera‐Gómez Francisco , Álvarez Francisco Javier 
Published: April 2021

AbstractBackgroundFirst‐generation antihistamines are considered driving‐impairing medicines (DIM), while second‐ and third‐generation antihistamines are relatively safe for driving.ObjectivesThe aim of this study was to know the trend of consumption of antihistamines and other DIMs in Spain between 2015 and 2019.MethodsThis is a population‐based registry study. The population distribution by age and gender has been taken into account, as well the treatment duration with these medicines and the concomitant use of other DIMs. Adjusted consumption for licensed drivers is also presented.ResultsBetween 2015 and 2019, antihistamines were dispensed to 12.1% of the population and 9.25% of drivers. Oral antihistamines are the most consumed with 85.83%, and generally more used by women than men. Regardless of systemic antihistamines, the second‐generation were the most consumed (8.9%) followed by the third‐generation (2.07%) and the first‐generation (0.61%). Subacute use was predominant in second ‐generation antihistamines (4.96%) and third‐generation (1.26%), while acute use was predominant in third‐generation antihistamines. On the other hand, only 0.36% of the population consumed antihistamines daily. The concomitant use of antihistamines with other DIMS was considerable, especially anxiolytics, opioids, other analgesics and antipyretics and antidepressants. The results in drivers were similar than in the general population.ConclusionsThe use of antihistamines has increased in recent years, however, in Spain, the use of less sedatives predominates, which is safe for driving. Finally, it is important to consider that concomitant use with other DIMs was frequent, which may affect the fitness to drive.
Monopoly rents, institutions, and bribery
Authors: Zhu Boliang , Deng Qing 
Published: April 2021

AbstractWhy do some firms pay more bribes than others? We extend the literature by examining the role of one crucial, but overlooked industry characteristic—fixed‐asset intensity—in shaping firms' bribe payments. High fixed‐asset intensity creates natural entry barriers, thereby resulting in market concentration and opportunities for monopoly rent extraction. High rents, in turn, increase the value of government officials' “control rights” and thus their incentive to engage in predatory behavior. Firms in fixed‐asset intensive industries therefore have strong incentives to pay bribes in exchange for de facto property rights. We further posit that strong enforcement of the law weakens this quid pro quo by providing security for property rights and increasing the risk for government officials' behaving corruptly. We find empirical support for our arguments based on data from a large firm survey in China. Our findings have important implications for governance and industrial regulations in developing countries.
Bcl‐2‐negative IGH‐BCL2 translocation‐negative follicular lymphoma of the thyroid differs genetically and epigenetically from Bcl‐2‐positive IGH‐BCL2 translocation‐positive follicular lymphoma
Authors: Hamamoto Yuichiro , Kukita Yoji , Kitamura Masanori , Kurashige Masako , Masaie Hiroaki , Fuji Shigeo , Ishikawa Jun , Honma Keiichiro , Wakasa Tomoko , Hanamoto Hitoshi , Hirokawa Mitsuyoshi , Suzuki Ayana , Morii Eiichi , Nakatsuka Shin‐ichi 
Published: April 2021

AimsFollicular lymphoma (FL), comprising a minor subset of primary thyroid lymphomas, is divided into two groups based on Bcl‐2 expression and IGH‐BCL2 translocation. The clinicopathological features exhibited by Bcl‐2‐negative IGH‐BCL2 translocation‐negative FL of the thyroid (Bcl‐2–/IGH‐BCL2– tFL) are different from those of conventional FL; however, its lymphomagenesis remains unclear. Here, we collected samples from seven patients with Bcl‐2–/IGH‐BCL2– tFL to investigate their epigenetic and genetic aberrations.Methods and resultsThe immunohistochemical profiles of epigenetic modifiers and the methylation status of histones were examined, including EZH2, MLL2/KMT2D, CBP/CREBBP, EP300, H3K27me3 and H3K4me3, in Bcl‐2–/IGH‐BCL2– tFL and Bcl‐2‐positive IGH‐BCL2 translocation‐positive FL of the thyroid (Bcl‐2+/IGH‐BCL2+ tFL). Most Bcl‐2–/IGH‐BCL2– tFLs retained the positivity of epigenetic modifiers and lower expression of H3K27me3, although Bcl‐2+/IGH‐BCL2+ tFLs exhibited aberrant immunohistochemical patterns of EZH2 and CBP/CREBBP and overexpression of H3K27me3. Samples from seven cases were further analysed using targeted sequencing, focusing on the exons of 409 key tumour suppressor genes and oncogenes. Bcl‐2–/IGH‐BCL2– tFLs do not have pathogenic mutations of epigenetic modifiers, such as EZH2, MLL2/KMT2D, MLL3/KMT2C, EP300 and ARID1A, which have been reported in FLs in the literature, whereas Bcl‐2+/IGH‐BCL2+ tFLs are probably pathogenic/pathogenic missense mutations or frameshift mutations of these genes. Additionally, novel mutations in TET2 and EP400 were detected in Bcl‐2–/IGH‐BCL2– tFLs.ConclusionsDifferent genetic and epigenetic abnormalities might be involved in the oncogenesis of Bcl‐2–/IGH‐BCL2– tFLs from Bcl‐2+/IGH‐BCL2+ tFLs and other FLs.
Improving dental‐oral health learning in students using a mobile application (“My tooth“): A controlled before and after study
Authors: Rahaei Zohreh , Moradian Elham , Falahati‐Marvast Fatemeh 
Published: April 2021

AbstractObjectivesTooth decay is one of the most common problems amongst students. Despite considerable educational interventions, it is still very prevalent. The aim of this study was to compare the effect of a dental‐oral health mobile educational application with the common dental‐oral health education amongst elementary school students.MethodsThis interventional study was carried out on 158 girl students in the age range of 10–12 years in Mobarakeh City, Iran. The participants were categorized into the intervention and control groups and investigated in the academic year of 2018–2019. The research tool was a researcher‐made questionnaire with confirmed validity and reliability. Initially, all students completed the questionnaires. Later, the intervention group members were trained using dental‐oral health mobile educational application and control group received the common dental‐oral health educations in lectures and demonstrations. Two months after the last intervention, the same questionnaire was completed and data were analysed by SPSS software.ResultsBefore the intervention, the mean score of behaviour was 13.69 ± 3.89 and 13.93 ± 3.02 (of 21) for the intervention and control groups. At this phase, the difference between the two groups was not significant in the studied dimensions (p > 0.05). After the intervention, mean scores of the intervention group increased significantly with regard to all variables (p < 0.05).ConclusionsFindings of this study confirmed the positive effect of learning through mobile applications on increasing the students' knowledge, attitude and performance regarding dental‐oral health education.
Comparative phylogeography reveals consistently shallow genetic diversity in a mitochondrial marker in Antarctic bdelloid rotifers
Authors: Cakil Zeyneb Vildan , Garlasché Giuseppe , Iakovenko Nataliia , Di Cesare Andrea , Eckert Ester M. , Guidetti Roberto , Hamdan Lina , Janko Karel , Lukashanets Dzmitry , Rebecchi Lorena , Schiaparelli Stefano , Sforzi Tommaso , Kašparová Eva Štefková , Velasco‐Castrillón Alejandro , Walsh Elizabeth J. , Fontaneto Diego 
Published: April 2021

AbstractAimThe long history of isolation of the Antarctic continent, coupled with the harsh ecological conditions of freezing temperatures, could affect the patterns of genetic diversity in the organisms living there. We aim (a) to test whether such pattern can be seen in a mitochondrial marker of bdelloid rotifers, a group of microscopic aquatic and limno‐terrestrial animals and (b) to speculate on the potential mechanisms driving the pattern.LocationFocus on Antarctica.TaxonRotifera Bdelloidea.MethodsWe analysed different metrics of genetic diversity, also spatially explicit ones, including number of haplotypes, accumulation curves, genetic distances, time to the most recent common ancestor, number of independently evolving units from DNA taxonomy, strength of the correlation between geographical and genetic distances, population genetics neutrality and differentiation indices, potential historical processes, obtained from an extensive sample of cytochrome oxidase subunit I (COI) sequences obtained from bdelloid rotifers. We included 2242 individuals from 23 species in a comparison between Antarctic and non‐Antarctic taxa, correcting for sample size directly in the analyses and then by confirming the results also using only a restricted dataset of nine well‐sampled species.ResultsAntarctic species had consistently lower genetic diversity and potential younger relative age than non‐Antarctic species, even if they were similar in sample size, geographical extent, neutrality and differentiation indices, and correlation between genetic and geographical distances.Main conclusionsThe extensive survey of genetic diversity in one mitochondrial marker in Antarctic bdelloids supports previous suggestions from other organisms that the origin and maintenance of terrestrial Antarctic fauna are different from those of other continents. Such differences could be speculated to be due, in the case of bdelloid rotifers, to the more recent origin of the species living there in comparison to non‐Antarctic species.
Atopic dermatitis among children and adolescents in the Arctic region – a systematic review and meta‐analysis
Authors: Andersson A.M. , Halling A.S. , Loft N. , Skov L. , Koch A. , Guttman‐Yassky E. , Thyssen J.P. 
Published: April 2021

AbstractThe prevalence of atopic dermatitis (AD) varies across the globe, and the clinical phenotype with racial background and ethnicity. AD in the Arctic region has only been scarcely studied. We performed a systematic review and meta‐analysis to examine the prevalence, clinical manifestations and risk factors for AD among children and adolescents in the Arctic. Three medical databases PubMed, Embase and Web of Science were screened. All studies published between 1990 to 2020 with epidemiologic data on AD in children and adolescents in the Arctic region, were included. Data were extracted and a meta‐analysis was performed to obtain pooled proportions and incidences with 95% confidence intervals (CI). We identified 21 studies from 8 different Arctic regions with 31 403 participants. The cumulative incidence of AD was 23% (95% CI 20–26) and 1‐year prevalence was 19% (95% CI 15–25). The incidence of AD was higher in the Arctic parts of Scandinavia and lower in Greenland and Russia. Children of indigenous descent had a slightly lower incidence of AD (19%, 95% CI 13–26) compared to the overall population. The dominant phenotype of AD was mild to moderate flexural dermatitis with facial involvement. Asthma and allergic rhinitis were common and observed in 20–30% of children with AD. In conclusion, AD is highly prevalent in the Arctic, but varies between regions and races. Indigenous children living in less urbanized countries appear to have a slightly lower risk of AD. Future studies should confirm this and examine whether this correlation relates to behavioural differences or genetic signature.
Exclusive content in two‐sided markets
Authors: Ishihara Akifumi , Oki Ryoko 
Published: April 2021

AbstractThis study investigates the role of exclusive content provision in two‐sided markets in which both sides are allowed to join multiple platforms. We consider a model of duopolistic two‐sided platform market with a monopolistic multiproduct firm (content provider) on one side and consumers on the other. The model demonstrates that the monopolistic content provider uses exclusivity as strategic commitment to balance two opposite effects on its bargaining power: the positive effect caused by the increase in multihoming consumers and the negative effect caused by the restriction of distribution channels.
UK Dietitians’ views on communication skills for behaviour change: A 10 year follow‐up survey
Authors: Whitehead Kirsten , Parkin Tracey 
Published: April 2021

AbstractBackgroundIn 2007, a survey of UK dietitians identified that dietitians were positive about the use of Communication Skills for Behaviour Change (CSBC) in practice, although barriers to the implementation of skills were acknowledged. This follow‐up survey aimed to explore current perceptions of CSBC and compare them with the previous survey.MethodsA cross‐sectional online survey of British Dietetic Association (BDA) members’ views of CSBC was undertaken. The results for full members are presented. Quantitative data were analysed descriptively. Qualitative data were subject to either content, or inductive thematic analysis.ResultsA response rate of 9.4% (n = 729) was achieved. Respondents were predominately female (n = 684; 95.1%) and worked in the National Health Service (n = 634; 87.4%). They were positive about the importance of CSBC in practice (n = 714; 99.5%). Pre‐registration training had been completed by 346 respondents (48.7%).Post‐registration training had been undertaken by 520 (74.7%) respondents and 514 of these (99.6%) had implemented training into practice, with few barriers identified. Perception of ability to use skills had increased, with 513 (83.6%) respondents rating their skills as excellent/very good compared to 62% previously. The majority (n = 594; 93.7%) reported that post‐registration training was necessary, with the need for skills to be regularly reviewed (n = 456; 74.5%), and 235 (51.9%) respondents suggested this be mandatory. By contrast, some suggested that a skill review was not a priority, and would be difficult to administer and stressful.ConclusionsPerception of the importance of CSBC remains high. Although the perceived ability to apply CSBC has increased, the perceived need for post‐registration training is high, with respondents’ favouring mandatory training.
Resilience in Multicultural Families of Children With Disabilities in Korea: A Path Analysis Using National Data
Authors: Oh Won‐Oak , Heo Yoo Jin , Lee Anna 
Published: April 2021

AbstractPurposeThe number of multicultural families has increased globally, and Korea has also witnessed a surge. Along with the various challenges experienced by these families, a child with a disability can pose additional challenges. In‐depth knowledge about resilience factors among multicultural families of children with disabilities is important. The aim of this study was to examine relationships between family demands, family appraisals, family problem solving and coping, family resources, and family adaptation in multicultural families of children with disabilities in Korea as perceived by married immigrants.DesignThis study was based on a secondary analysis of national survey data in 2015 and 2018 in Korea.MethodsA total of 256 multicultural families who have children with disabilities participated. Family demands were identified by examining marital conflict, cultural differences, marital status, and public assistance recipient households. Family appraisal was assessed by how the family perceived the married immigrant’s culture. Family problem solving and coping were examined by how actively a married immigrant participated in social activities. Family resources were assessed by examining Korean language competency and the health status of immigrants. Family adaptation was identified by how immigrants perceived their life satisfaction. Path analysis was used to assess the factors.FindingsFamily demands had a direct impact on family resources and family adaptation. Family appraisal had a direct impact on family adaptation. Family resources mediated the effect of family demands on family adaptation.ConclusionsThis study demonstrated that although a multicultural family of a child with a disability struggles with family demands, if the family receives positive resources from family members, they can adapt well. Current findings can be used to develop interventions that can foster greater resilience among families.Clinical RelevanceThis study provides evidence that nurses can target modifiable family aspects, including immigrants’ health and family perceptions of immigrants’ cultures identified in this study to enhance the immigrant and family adaptation.
Connecting with the future: The role of science fiction movies in helping consumers understand privacy‐technology trade‐offs
Authors: Milne George R. , Kaplan Begum , Walker Kristen L. , Zacharias Larry 
Published: April 2021

AbstractThis article examines the ways in which sci‐fi films help consumers understand the tradeoffs between personal privacy concerns and other societal concerns that arise due to new technologies. Drawing upon media priming theory, the authors present a conceptual framework and accompanying research questions that suggest how priming from a futuristic movie influences consumers sentiment toward technology and privacy, from its release date and throughout its availability on movie streaming services. Through a series of studies, including qualitative analysis and text‐based sentiment analysis of reviews in the IMBD database, the authors provide evidence to support this theoretical conceptualization. The findings demonstrate that online reviews are useful as a data source to gauge emotional intensity and text analysis of science fiction film reviews provides a useful methodology for understanding consumer perceptions about the future. Science fiction movies may help consumers frame privacy‐technology tradeoffs and take action to protect their privacy.