bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal modeling of first and second wave outbreak dynamics of COVID-19 in Germany
Authors: Lippold Dorothee , Kergaßner Andreas , Burkhardt Christian , Kergaßner Matthias , Loos Jonas , Nistler Sarah , Steinmann Paul , Budday Dominik , Budday Silvia 
Published: October 2021

AbstractThe COVID-19 pandemic has kept the world in suspense for the past year. In most federal countries such as Germany, locally varying conditions demand for state- or county-level decisions to adapt to the disease dynamics. However, this requires a deep understanding of the mesoscale outbreak dynamics between microscale agent models and macroscale global models. Here, we use a reparameterized SIQRD network model that accounts for local political decisions to predict the spatiotemporal evolution of the pandemic in Germany at county resolution. Our optimized model reproduces state-wise cumulative infections and deaths as reported by the Robert Koch Institute and predicts the development for individual counties at convincing accuracy during both waves in spring and fall of 2020. We demonstrate the dominating effect of local infection seeds and identify effective measures to attenuate the rapid spread. Our model has great potential to support decision makers on a state and community politics level to individually strategize their best way forward during the months to come.
The first families of highly symmetric Kirkman Triple Systems whose orders fill a congruence class
Authors: Bonvicini Simona , Buratti Marco , Garonzi Martino , Rinaldi Gloria , Traetta Tommaso 
Published: October 2021

AbstractKirkman triple systems (KTSs) are among the most popular combinatorial designs and their existence has been settled a long time ago. Yet, in comparison with Steiner triple systems, little is known about their automorphism groups. In particular, there is no known congruence class representing the orders of a KTS with a number of automorphisms at least close to the number of points. We partially fill this gap by proving that whenever$$v \equiv 39$$v≡39(mod 72), or$$v \equiv 4^e48 + 3$$v≡4e48+3(mod$$4^e96$$4e96) and$$e \ge 0$$e≥0, there exists a KTS onvpoints having at least$$v-3$$v-3automorphisms. This is only one of the consequences of an investigation on the KTSs with an automorphism groupGacting sharply transitively on all but three points. Our methods are all constructive and yield KTSs which in many cases inherit some of the automorphisms ofG, thus increasing the total number of symmetries. To obtain these results it was necessary to introduce new types of difference families (the doubly disjoint ones) and difference matrices (the splittable ones) which we believe are interesting by themselves.
Creatine deficiency and heart failure
Authors: Del Franco Annamaria , Ambrosio Giuseppe , Baroncelli Laura , Pizzorusso Tommaso , Barison Andrea , Olivotto Iacopo , Recchia Fabio A. , Lombardi Carlo M. , Metra Marco , Ferrari Chen Yu F. , Passino Claudio , Emdin Michele , Vergaro Giuseppe 
Published: October 2021

AbstractImpaired cardiac energy metabolism has been proposed as a mechanism common to different heart failure aetiologies. The energy-depletion hypothesis was pursued by several researchers, and is still a topic of considerable interest. Unlike most organs, in the heart, the creatine kinase system represents a major component of the metabolic machinery, as it functions as an energy shuttle between mitochondria and cytosol. In heart failure, the decrease in creatine level anticipates the reduction in adenosine triphosphate, and the degree of myocardial phosphocreatine/adenosine triphosphate ratio reduction correlates with disease severity, contractile dysfunction, and myocardial structural remodelling. However, it remains to be elucidated whether an impairment of phosphocreatine buffer activity contributes to the pathophysiology of heart failure and whether correcting this energy deficit might prove beneficial. The effects of creatine deficiency and the potential utility of creatine supplementation have been investigated in experimental and clinical models, showing controversial findings. The goal of this article is to provide a comprehensive overview on the role of creatine in cardiac energy metabolism, the assessment and clinical value of creatine deficiency in heart failure, and the possible options for the specific metabolic therapy.
Completeness for the Classical Antecedent Fragment of Inquisitive First-Order Logic
Authors: Grilletti Gianluca 
Published: October 2021

AbstractInquisitive first order logic "Equation missing" is an extension of first order classical logic, introducing questions and studying the logical relations between questions and quantifiers. It is not known whether "Equation missing" is recursively axiomatizable, even though an axiomatization has been found for fragments of the logic (Ciardelli, 2016). In this paper we define the $$\mathsf {ClAnt}$$
ClAnt
—classical antecedent—fragment, together with an axiomatization and a proof of its strong completeness. This result extends the ones presented in the literature and introduces a new approach to study the axiomatization problem for fragments of the logic.
Radiocarbon Dated Trends and Central Mediterranean Prehistory
Authors: Parkinson Eóin W. , McLaughlin T. Rowan , Esposito Carmen , Stoddart Simon , Malone Caroline 
Published: October 2021

AbstractThis paper reviews the evidence for long term trends in anthropogenic activity and population dynamics across the Holocene in the central Mediterranean and the chronology of cultural events. The evidence for this has been constituted in a database of 4608 radiocarbon dates (of which 4515 were retained for analysis following initial screening) from 1195 archaeological sites in southern France, Italy and Malta, spanning the Mesolithic to Early Iron Age periods, c. 8000 to 500 BC. We provide an overview of the settlement record for central Mediterranean prehistory and add to this an assessment of the available archaeological radiocarbon evidence in order to review the traditional narratives on the prehistory of the region. This new chronology has enabled us to identify the most significant points in time where activity levels, population dynamics and cultural change have together caused strong temporal patterning in the archaeological record. Some of these episodes were localized to one region, whereas others were part of pan-regional trends and cultural trajectories that took many centuries to play out fully, revealing prehistoric societies subject to collapse, recovery, and continuing instability over the long-term. Using the radiocarbon evidence, we model growth rates in the various regions so that the tempo of change at certain points in space and time can be identified, compared, and discussed in the context of demographic change. Using other published databases of radiocarbon data, we have drawn comparisons across the central Mediterranean to wider prehistoric Europe, and northern Africa. Finally, we include a brief response to the synchronously published but independently developed paper (Palmisano et al. in J World Prehist 34(3), 2021). While there are differences in our respective approaches, we share the general conclusions that large-scale trends can been identified through meta-analyses of the archaeological record, and these offer new perspectives on how society functioned.
Big data theory based spectrum sensing algorithm for the satellite cognitive radio network
Authors: Yang Mingchuan , Shao Xinye , Xue Guanchang , Xie Bingyu 
Published: October 2021

AbstractIn order to deal with the difficulty of spectrum sensing in cognitive satellite wireless networks, a large-scale cognitive network spectrum sensing algorithm based on big data analysis theory is studied, and a new algorithm using mean exponential eigenvalue is proposed. This new approach fully uses all the eigenvalues in sample covariance matrix of the sensing results to make the decision, which can effectively improve the detection performance without obtaining the prior information from licensed users. Through simulation, the performance of various large scale cognitive radio spectrum sensing algorithms based on big data analysis theory is compared, and the influence of satellite to ground channel conditions and the number of sensing nodes on the performance of the algorithm is discussed.
Social Participation as a Moderator for Caregivers’ Psychological Distress: a Dynamic Panel Data Model Analysis in Japan
Authors: Oshio Takashi , Sugiyama Kemmyo 
Published: October 2021

AbstractThe adverse impact of caregiving on caregivers’ mental health and the positive impact of social participation (SP) on health are both well understood. This study examined the moderating effect of SP on the association between family caregiving and caregivers’ psychological distress (PD). We used longitudinal data from 27,869 individuals born between 1946 and 1955 collected from a 14-wave nationwide survey, which was conducted from 2005 to 2018. We estimated dynamic panel data models, which could control for an individual’s time-invariant attributes in a dynamic framework, to examine how SP moderated the association between informal caregiving and a caregiver’s PD (defined by a Kessler score of 13 or higher). We observed that the onset of caregiving increased the probability of PD by 2.1% (95% confidence interval [CI]: 1.5%–2.6%) and 1.0% (95% CI: 0.5%–1.6%) for women and men, respectively, compared to 3.4% and 2.8% as the prevalence of PD for women and men, respectively. SP moderated the association between caregiving and a caregiver’s PD by 55.8% (95% CI: 31.9%–79.8%) and 73.5% (95% CI: 36.1%–110.9%) for women and men, respectively. In addition, the moderating effect of SP on a caregiver’s PD increased as the caregiver’s age advanced especially in women. These results suggest the need to keep family caregivers from being socially isolated, especially as they get older.
Some results on isometric composition operators on Lipschitz spaces
Authors: Rueda Zoca Abraham 
Published: October 2021

AbstractGiven two metric spaces M and N we study, motivated by a question of N. Weaver, conditions under which a composition operator $$C_\phi :{\mathrm {Lip}}_0(M)\longrightarrow {\mathrm {Lip}}_0(N)$$

C
ϕ

:

Lip
0

(
M
)

⟶

Lip
0

(
N
)

is an isometry depending on the properties of $$\phi $$
ϕ
. We obtain a complete characterisation of those operators $$C_\phi $$

C
ϕ

in terms of a property of the function $$\phi $$
ϕ
in the case that $$B_{{\mathcal {F}}(M)}$$

B

F
(
M
)

is the closed convex hull of its preserved extreme points. Also, we obtain necessary condition for $$C_\phi $$

C
ϕ

being an isometry in the case that M is geodesic.
Personalization of medical treatments in oncology: time for rethinking the disease concept to improve individual outcomes
Authors: Bizzarri Mariano , Fedeli Valeria , Monti Noemi , Cucina Alessandra , Jalouli Maroua , Alwasel Saleh H. , Harrath Abdel Halim 
Published: October 2021

AbstractThe agenda of pharmacology discovery in the field of personalized oncology was dictated by the search of molecular targets assumed to deterministically drive tumor development. In this perspective, genes play a fundamental “causal” role while cells simply act as causal proxies, i.e., an intermediate between the molecular input and the organismal output. However, the ceaseless genomic change occurring across time within the same primary and metastatic tumor has broken the hope of a personalized treatment based only upon genomic fingerprint. Indeed, current models are unable in capturing the unfathomable complexity behind the outbreak of a disease, as they discard the contribution of non-genetic factors, environment constraints, and the interplay among different tiers of organization. Herein, we posit that a comprehensive personalized model should view at the disease as a “historical” process, in which different spatially and timely distributed factors interact with each other across multiple levels of organization, which collectively interact with a dynamic gene-expression pattern. Given that a disease is a dynamic, non-linear process — and not a static-stable condition — treatments should be tailored according to the “timing-frame” of each condition. This approach can help in detecting those critical transitions through which the system can access different attractors leading ultimately to diverse outcomes — from a pre-disease state to an overt illness or, alternatively, to recovery. Identification of such tipping points can substantiate the predictive and the preventive ambition of the Predictive, Preventive and Personalized Medicine (PPPM/3PM). However, an unusual effort is required to conjugate multi-omics approaches, data collection, and network analysis reconstruction (eventually involving innovative Artificial Intelligent tools) to recognize the critical phases and the relevant targets, which could help in patient stratification and therapy personalization.
Season- and Trend-aware Symbolic Approximation for Accurate and Efficient Time Series Matching
Authors: Kegel Lars , Hartmann Claudio , Thiele Maik , Lehner Wolfgang 
Published: October 2021

AbstractProcessing and analyzing time series datasets have become a central issue in many domains requiring data management systems to support time series as a native data type. A core access primitive of time series is matching, which requires efficient algorithms on-top of appropriate representations like the symbolic aggregate approximation (SAX) representing the current state of the art. This technique reduces a time series to a low-dimensional space by segmenting it and discretizing each segment into a small symbolic alphabet. Unfortunately, SAX ignores the deterministic behavior of time series such as cyclical repeating patterns or a trend component affecting all segments, which may lead to a sub-optimal representation accuracy. We therefore introduce a novel season- and a trend-aware symbolic approximation and demonstrate an improved representation accuracy without increasing the memory footprint. Most importantly, our techniques also enable a more efficient time series matching by providing a match up to three orders of magnitude faster than SAX.
Parametric whirl flutter study using different modelling approaches
Authors: Koch Christopher 
Published: October 2021

AbstractThis paper demonstrates the importance of assessing the whirl flutter stability of propeller configurations with a detailed aeroelastic model instead of local pylon models. Especially with the growing use of electric motors for propulsion in air taxis and commuter aircraft whirl flutter becomes an important mode of instability. These configurations often include propeller which are powered by lightweight electric motors and located at remote locations, e.g. the wing tip. This gives rise to an aeroelastic instability called whirl flutter, involving the gyroscopic whirl modes of the engine. The driving parameters for this instability are the dynamics of the mounting structure. Using a generic whirl flutter model of a propeller at the tip of a lifting surface, parameter studies on the flutter stability are carried out. The aeroelastic model consists of a dynamic MSC.Nastran beam model coupled with the unsteady ZAERO ZONA6 aerodynamic model and strip theory for the propeller aerodynamics. The parameter studies focus on the influence of different substructures (ranging from local engine mount stiffness to global aircraft dynamics) on the aeroelastic stability of the propeller. The results show a strong influence of the level of detail of the aeroelastic model on the flutter behaviour. The coupling with the lifting surface is of major importance, as it can stabilise the whirl flutter mode. Including wing unsteady aerodynamics into the analysis can also change the whirl flutter behaviour. This stresses the importance of including whirl flutter in the aeroelastic stability analysis on aircraft level.
The Overlap Between Problematic Smartphone Use and Problematic Social Media Use: a Systematic Review
Authors: Marino Claudia , Canale Natale , Melodia Fiordalisa , Spada Marcantonio M. , Vieno Alessio 
Published: October 2021

Abstract
Purpose of Review
Over the last decade, problematic smartphone use (PSU) and problematic social media use (PSMU) have emerged as new potential problematic behaviours. Several studies have suggested that smartphones are predominantly used for social purposes (i.e., using messaging apps and social networking sites). The aim of the current article is to provide a systematic review of the extant literature that has explicitly analysed the association between PSU and PSMU in order to examine study characteristics in terms of samples analysed and effect sizes of the associations reported. This systematic review is based on the ongoing debate about whether the smartphone can be considered as the medium of one or more problematic activities, including PSMU.

Recent Findings
Existing evidence suggests that the effect sizes of the associations between PSU and PSMU are medium to large and large across the 13 studies included, with the largest correlations observed between PSU and problematic WhatsApp use or general PSMU. Overall, reviewed results suggest a partial overlap between the two problematic behaviours.

Summary
PSU and PSMU are overlapped mostly because the smartphone is a common medium to use social media, especially concerning instant messaging apps like WhatsApp. Moreover, PSU should be preferentially studied with a focus on specific types of apps used rather than a more holistic phenomenon.
Discordant Crown Rump Length (CRL) in Twins: Is it a Matter of Concern?—The Indian Perspective
Authors: Sabu Brinda , Suresh Sudarshan , Seshadri Suresh 
Published: October 2021

AbstractTo evaluate the impact of discordant Crown Rump Length (CRL) noted in the first trimester on the outcome of monochorionic (MC) and dichorionic (DC) twin gestations and to establish it's role as a predictor of adverse outcomes. This was a retrospective case control study carried out at a tertiary fetal medicine centre in South India between June 2013 and May 2018. Cases were obtained from the database of the centre. All viable monochorionic diamniotic (MCDA) and dichorionic diamniotic (DCDA) twin pregnancies scanned between 11 and 14 weeks gestational age after excluding fetuses with structural abnormalities were included in the study. The impact of discordant CRL ≥ 10% on the outcomes of twins was evaluated. Among 2627 twin pregnancies 2298 (87.5%) were dichorionic and 329 (12.5%) were monochorionic. Among the DC twin pregnancies CRL discordance ≥ 10% was found in 124 (5.4%) while 2174 (94.6%) were concordant. Among the MC twin pregnancies CRL discordance ≥ 10% was found in 20 (6.1%) while 309 (93.9%) were concordant. In DC twin pregnancies we found a significant association between CRL discordance of ≥ 10% and fetal loss (p = 0.001), mean GA at delivery (p = 0.002) and mean birth weight (p = 0.04). However in MC twin pregnancies we did not find any association between discordant CRL and adverse outcomes. When the CRL discordance cutoff was increased to ≥ 16% (95th centile), there was a significant increase in the aforementioned adverse outcomes in DC twin pregnancies while in MC twin pregnancies there was a significant increase in fetal loss (p = 0.027). To evaluate CRL discordance as a predictor of adverse outcomes, receiver operating curves were created for each outcome studied. But they failed to show the predictive accuracy in both CRL ≥ 10% and CRL ≥ 16% groups. CRL discordance in DC twin pregnancies are more commonly associated with adverse outcomes than MC twin pregnancies and it significantly increases when CRL C 16% (95th centile) was used as cutoff. Hence CRL discordance of ≥ 16% should be set as the cutoff to identify pregnancies at risk. However we reiterate that discordant CRL, irrespective of the cutoff used, is not a robust predictor of adverse outcomes.
Mechanical properties, crystallographic texture, and in vitro bio-corrosion of low-alloyed Zn–Mg, produced by hot and cold drawing for biodegradable surgical wires
Authors: Milenin Andrij , Wróbel Mirosław , Kustra Piotr , Packo Marek , Byrska-Wójcik Dorota , Sulej-Chojnacka Joanna , Płonka Bartłomiej 
Published: October 2021

Abstract
The paper is devoted to the study of the mechanical, microstructural, and bio-corrosive behavior of low-alloyed Zn–Mg biodegradable surgical wires for bone reconstructions. Three biodegradable alloys with different magnesium content have been studied, their production technology has been developed and the product properties have been determined. The technology includes casting, extrusion, hot and cold drawing of the wire, and the product surface finishing. The paper shows the most important stages of the process (i.e., extrusion and drawing) in detail. The technological parameters have been selected based on the results of the computer modeling. The flow stress–strain curves of extruded materials have been obtained at various strain rates and temperatures. Two drawing technologies have been compared. The first one is the room temperature conventional wire drawing. In the second one, the first few passes have been made at an elevated temperature and the rest at room temperature. This allowed avoiding the breaking of the wire during the first passes (a typical issue of the conventional technology for these alloys) and increasing the ductility of the final product. Mechanical properties, bio-corrosion, and crystallographic texture of the material were determined at different stages of the processing. A simultaneous increase in the wire strength, the number of repeated bending until the rupture of the wire, and in the bio-corrosion rate due to drawing has been registered. This phenomenon coincided with a change in the crystallographic texture. It has been shown that the product tensile strength of about 250–300 MPa can be reduced by about 30% due to surgical knots tied on it.
A Dramaturgy of Death: Performing (And Spectating) Filial Piety in Early China
Authors: Radice Thomas 
Published: October 2021

AbstractThis essay analyzes the early Chinese elite discourse on filial death rituals, arguing that early Chinese texts depict these rituals as performance events. Building on spectacle of xiao sacrifices in the Western Zhou Dynasty, Eastern Zhou authors conceived of filial death rituals as dramaturgical phenomena that underscored not only what needed to be performed, but also how it should be performed, and led to an important distinction between personal dispositions and inherited ritual protocol. This distinction, then, led to concerns about artifice in human behavior, both inside and outside the Ruist (Confucian) tradition. By end of the Warring States Period and in the early Western Han Dynasty, with the embracement of artifice in self-cultivation, the dramatic role of the filial son in death rituals became even more developed and complex, requiring the role of cultivated spectators to be engaged critics who recognized the nuances of cultivated performances.