bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collapse and Measures of Consciousness
Authors: Kent Adrian 
Published: May 2021

AbstractThere has been an upsurge of interest lately in developing Wigner’s hypothesis that conscious observation causes collapse by exploring dynamical collapse models in which some purportedly quantifiable aspect(s) of consciousness resist superposition. Kremnizer–Ranchin, Chalmers–McQueen and Okon–Sebastián have explored the idea that collapse may be associated with a numerical measure of consciousness. More recently, Chalmers–McQueen have argued that any single measure is inadequate because it will allow superpositions of distinct states of equal consciousness measure to persist. They suggest a satisfactory model needs to associate collapse with a set of measures quantifying aspects of consciousness, such as the “Q-shapes” defined by Tononi et al. in their “integrated information theory” (IIT) of consciousness. I argue here that Chalmers–McQueen’s argument against associating a single measure with collapse requires a precise symmetry between brain states associated with different experiences and thus does not apply to the only case where we have strong intuitions, namely human (or other terrestrial biological) observers. In defence of Chalmers–McQueen’s stance, it might be argued that idealized artificial information processing networks could display such symmetries. However, I argue that the most natural form of any theory (such as IIT) that postulates a map from network states to mind states is one that assigns identical mind states to isomorphic network states (as IIT does). This suggests that, if such a map exists, no familiar components of mind states, such as viewing different colours, or experiencing pleasure or pain, are likely to be related by symmetries.
Patients, primary care, and policy: Agent-based simulation modeling for health care decision support
Authors: Comis Martin , Cleophas Catherine , Büsing Christina 
Published: May 2021

AbstractPrimary care systems are a cornerstone of universally accessible health care. The planning, analysis, and adaptation of primary care systems is a highly non-trivial problem due to the systems’ inherent complexity, unforeseen future events, and scarcity of data. To support the search for solutions, this paper introduces the hybrid agent-based simulation model SiM-Care. SiM-Care models and tracks the micro-interactions of patients and primary care physicians on an individual level. At the same time, it models the progression of time via the discrete-event paradigm. Thereby, it enables modelers to analyze multiple key indicators such as patient waiting times and physician utilization to assess and compare primary care systems. Moreover, SiM-Care can evaluate changes in the infrastructure, patient behavior, and service design. To showcase SiM-Care and its validation through expert input and empirical data, we present a case study for a primary care system in Germany. Specifically, we study the immanent implications of demographic change on rural primary care and investigate the effects of an aging population and a decrease in the number of physicians, as well as their combined effects.
A latent variable approach to account for correlated inputs in global sensitivity analysis
Authors: Melillo Nicola , Darwich Adam S. 
Published: May 2021

AbstractIn drug development decision-making is often supported through model-based methods, such as physiologically-based pharmacokinetics (PBPK). Global sensitivity analysis (GSA) is gaining use for quality assessment of model-informed inference. However, the inclusion and interpretation of correlated factors in GSA has proven an issue. Here we developed and evaluated a latent variable approach for dealing with correlated factors in GSA. An approach was developed that describes the correlation between two model inputs through the causal relationship of three independent factors: the latent variable and the unique variances of the two correlated parameters. The latent variable approach was applied to a set of algebraic models and a case from PBPK. Then, this method was compared to Sobol’s GSA assuming no correlations, Sobol’s GSA with groups and the Kucherenko approach. For the latent variable approach, GSA was performed with Sobol’s method. By using the latent variable approach, it is possible to devise a unique and easy interpretation of the sensitivity indices while maintaining the correlation between the factors. Compared methods either consider the parameters independent, group the dependent variables into one unique factor or present difficulties in the interpretation of the sensitivity indices. In situations where GSA is called upon to support model-informed decision-making, the latent variable approach offers a practical method, in terms of ease of implementation and interpretability, for applying GSA to models with correlated inputs that does not violate the independence assumption. Prerequisites and limitations of the approach are discussed.
What Morality and Religion have in Common with Health? Pedagogy of Religion in the Formation of Moral Competence
Authors: Marek Zbigniew , Walulik Anna 
Published: May 2021

AbstractThe aim of the article is to discuss how pedagogy of religion can contribute to the formation of moral competence and how this competence is in turn conducive to a new quality of life. Such analysis seems to be extremely important for modern educational theory. There are controversies concerning the role of morality in human life and its relationship with religion, and at the same time there is an increasing body of research that highlights the place and importance of religion in the formation of healthy individuals and societies. At the same time, the problem of the relationship between morality, religion and health is by no means new. The biblical writers already pointed out the connection between good and life, and between evil and death on the other hand. Both health and illness were taken to have their physical, inner, and spiritual dimensions. While Kulikova and Malchukova (2019) review the pedagogical and psychological subject literature, they lack references to the pedagogy of religion as a scientific discipline. This article aims to outline the Christian perspective on the formation of moral competence and its relationship with human health, understood as physical, mental, social and spiritual well-being. The understanding of this relationships is built on anthropological and transcendent foundations. Christian anthropological perspective means the acceptance of the so-called “personalistic norm.” Christian transcendent framework of moral education refers to the divine reality of the only God, the Creator and Redeemer of man. Moral competence is the result of moral education, which aims at engaging all human faculties—reason, emotions, and will—in discovering, accepting and internalizing values. One way of fostering moral competence based on the pedagogy of religion is to use the principles of the so-called pedagogy of accompaniment and testimony.
Cartesian Lattice Counting by the Vertical 2-sum
Authors: Kohonen Jukka 
Published: May 2021

AbstractA vertical 2-sum of a two-coatom lattice L and a two-atom lattice U is obtained by removing the top of L and the bottom of U, and identifying the coatoms of L with the atoms of U. This operation creates one or two nonisomorphic lattices depending on the symmetry case. Here the symmetry cases are analyzed, and a recurrence relation is presented that expresses the number of nonisomorphic vertical 2-sums in some desired family of graded lattices. Nonisomorphic, vertically indecomposable modular and distributive lattices are counted and classified up to 35 and 60 elements respectively. Asymptotically their numbers are shown to be at least Ω(2.3122n) and Ω(1.7250n), where n is the number of elements. The number of semimodular lattices is shown to grow faster than any exponential in n.
Structured Evaluation of Rehabilitation Programs Outcomes in Psychiatry: Application of a Recovery-Centered Model
Authors: Vanzetto Simone , Zabotto Matteo , Fasciana Federica , Varinelli Alberto , Cirnigliaro Giovanna , Ferrara Luca , Dell’Osso Bernardo , Viganò Caterina 
Published: May 2021

AbstractRehabilitation is oriented to psychiatric patients’ recovery through specific techniques and structured projects, not yet fully standardized, carried out in territorial services. This study aims to apply an operational structured outcome indicator model (hospitalizations, continuity of care, LAI treatment adherence, working support) through a recovery-centered model in a rehabilitation community in Milan. This observational-retrospective study included 111 patients from a University High Assistance Rehabilitation Community (C.R.A.) based in Milan. Psychopathological and psychosocial functioning was evaluated with Kennedy Axis V, Brief Psychiatric Rating Scale (BPRS), Life Skills Profile (LSP), AR module of the VADO scale. Statistical analyses were performed using SPSS software version 19. Student t test and Wilcoxon Test were used to analyze quantitative variables, while McNemar test for qualitative variables. The minimum level of significance was set at 0.05 (p <0.05). The results showed that CRA rehabilitation program led to significant improvement in global functioning in terms of hospitalization reduction; improved continuity of care; stable adherence to psychopharmacological treatment with Long Acting Injectable (LAI) antipsychotics; stable employment maintenance during the year following discharge from the CRA. This study confirmed the utility of a structured outcome indicator model and highlighted its feasibility in daily clinical context of a rehabilitative community. Our results supported the effectiveness of a community-based rehabilitation program to improve individual functioning and clinical stability. However, further studies are required to better achieve the development of a recovery-oriented rehabilitation model and rigorously define an outcomes evaluation model.
A New View of the Solar Interface Region from the Interface Region Imaging Spectrograph (IRIS)
Authors: De Pontieu Bart , Polito Vanessa , Hansteen Viggo , Testa Paola , Reeves Katharine K. , Antolin Patrick , Nóbrega-Siverio Daniel Elias , Kowalski Adam F. , Martinez-Sykora Juan , Carlsson Mats , McIntosh Scott W. , Liu Wei , Daw Adrian , Kankelborg Charles C. 
Published: May 2021

AbstractThe Interface Region Imaging Spectrograph (IRIS) has been obtaining near- and far-ultraviolet images and spectra of the solar atmosphere since July 2013. IRIS is the highest resolution observatory to provide seamless coverage of spectra and images from the photosphere into the low corona. The unique combination of near- and far-ultraviolet spectra and images at sub-arcsecond resolution and high cadence allows the tracing of mass and energy through the critical interface between the surface and the corona or solar wind. IRIS has enabled research into the fundamental physical processes thought to play a role in the low solar atmosphere such as ion–neutral interactions, magnetic reconnection, the generation, propagation, and dissipation of waves, the acceleration of non-thermal particles, and various small-scale instabilities. IRIS has provided insights into a wide range of phenomena including the discovery of non-thermal particles in coronal nano-flares, the formation and impact of spicules and other jets, resonant absorption and dissipation of Alfvénic waves, energy release and jet-like dynamics associated with braiding of magnetic-field lines, the role of turbulence and the tearing-mode instability in reconnection, the contribution of waves, turbulence, and non-thermal particles in the energy deposition during flares and smaller-scale events such as UV bursts, and the role of flux ropes and various other mechanisms in triggering and driving CMEs. IRIS observations have also been used to elucidate the physical mechanisms driving the solar irradiance that impacts Earth’s upper atmosphere, and the connections between solar and stellar physics. Advances in numerical modeling, inversion codes, and machine-learning techniques have played a key role. With the advent of exciting new instrumentation both on the ground, e.g. the Daniel K. Inouye Solar Telescope (DKIST) and the Atacama Large Millimeter/submillimeter Array (ALMA), and space-based, e.g. the Parker Solar Probe and the Solar Orbiter, we aim to review new insights based on IRIS observations or related modeling, and highlight some of the outstanding challenges.
Calibration of Design Models for Leakage Management of Water Distribution Networks
Authors: Berardi L. , Giustolisi O. 
Published: May 2021

AbstractWater losses in urban water distribution networks (WDN) accelerate the deterioration of such infrastructures. The enhanced hydraulic modelling provides a phenomenological representation of WDN hydraulics, including the modelling of leakages as function of pipe average pressure and deterioration. The methodological use of such models on real WDN was demonstrated to support the planning of leakage management actions. Nonetheless, many water utilities are still in the process of designing flow/pressure monitoring, thus data available are not enough to perform detailed calibration of such models.This work presents a physically based approach for the calibration of WDN hydraulic models aimed at supporting leakage management plans since early stages. The proposed procedure leverages the key role of mass balance in enhanced hydraulic models and the technical insight on pipe deterioration mechanisms for various quantity and quality of available data. Two calibration studies of real WDNs demonstrate the feasibility of the approach and show that the distribution of leakages in the WDN does not much influence the pressure values, which confirms the need for flow measurements at monitoring districts for leakage and asset management.
Effects of particle size of dielectric fillers on the output performance of piezoelectric and triboelectric nanogenerators
Authors: Meng Xiao , Zhang Zhuo , Lin Dabin , Liu Weiguo , Zhou Shun , Ge Shaobo , Su Yongming , Peng Chang , Zhang Lin 
Published: May 2021

AbstractRecently, piezoelectric/triboelectric nanogenerators based on piezoelectric composite materials have been intensively studied to achieve high electrical output performance. In this work, flexible BaTiO3 (BT)/PDMS nanocomposite films with various sizes and concentrations were fabricated and used as the nanogenerators. The influence of dielectric properties on the electrical output of nanogenerators was studied as well as the structure of the composites. The dielectric constant increased from 6.5 to 8 with the concentration of BT nanoparticles and decreased with the frequency from 102 to 106 Hz. Furthermore, the dielectric constant showed 11% decrease with the temperature range from 30 to 180 °C. It was found that the concentration of BT nanoparticles has promoted the electrical output of nanogenerators. The output voltage and current are all enhanced with the BT nanoparticles, which reached 200 V and 0.24 °A in TENG with 40 wt% BT nanoparticles, respectively. The selected device exhibited the power of 0.16 mW and employed to demonstrate its ability to power wearable/portable electronics by lighting the LEDs.
Integrating Remote Sensing and Indigenous Archaeology to Locate Unmarked Graves
Authors: Wadsworth William T. D. , Supernant Kisha , Dersch Ave ,   the Chipewyan Prairie First Nation
Published: May 2021

AbstractArchaeologists have long been called on to use geophysical techniques to locate unmarked graves in both archaeological and forensic contexts. Although these techniques—primarily ground-penetrating radar (GPR)—have demonstrated efficacy in this application, there are fewer examples of studies driven by Indigenous community needs. In North America, the location of ancestors and burial grounds is a priority for most Indigenous communities. We argue that when these Indigenous voices are equitably included in research design, the practice of remote sensing changes and more meaningful collaborations ensue. Drawing on Indigenous archaeology and heart-centered practices, we argue that remote-sensing survey methodologies, and the subsequent narratives produced, need to change. These approaches change both researchers’ and Indigenous communities’ relationships to the work and allow for the inclusion of Indigenous Knowledge (IK) in interpretation. In this article, we discuss this underexplored research trajectory, explain how it relates to modern GPR surveys for unmarked graves, and present the results from a survey conducted at the request of the Chipewyan Prairie First Nation. Although local in nature, we discuss potential benefits and challenges of Indigenous remote sensing collaborations, and we engage larger conversations happening in Indigenous communities around the ways these methods can contribute to reconciliation and decolonization.
Defining Regions of Pre-Colonial Africa: A Controlled Vocabulary for Linking Open-Source Data in Digital History Projects
Authors: Lovejoy Henry B. , Lovejoy Paul E. , Hawthorne Walter , Alpers Edward A. , Candido Mariana , Hopper Matthew S. , Lydon Ghislaine , Kriger Colleen E. , Thornton John 
Published: May 2021

AbstractRegionalizing pre-colonial Africa aids in the collection and interpretation of primary sources as data for further analysis. This article includes a map with six broad regions and 34 sub-regions, which form a controlled vocabulary within which researchers may geographically organize and classify disparate pieces of information related to Africa’s past. In computational terms, the proposed African regions serve as data containers in order to consolidate, link, and disseminate research among a growing trend in digital humanities projects related to the history of the African diasporas before c. 1900. Our naming of regions aims to avoid terminologies derived from European slave traders, colonialism, and modern-day countries.
‘Great angels’ in Antrim: Hugh Shearman, theosophist perceptions, and Ulster unionist public relations
Authors: Maume Patrick 
Published: May 2021

AbstractThis article argues that the career and writings of the Ulster unionist propagandist and man of letters Hugh Shearman (1915–99) were influenced by his commitment to theosophy, which he saw as a logical extension of Protestant belief in private judgement. His work as a publicist echoed theosophist preoccupation with illusion and the perceptions accessible to initiates. Many of his writings displayed theosophist in-jokes, esoteric references and mental reservations. His apologias reflected theosophist belief in the breaking down of personality compartmentalisation in order to merge with the world-soul. Shearman saw the Irish republic as the ‘Pakistan of the West’, represented by him as embodying self-destructive insularity shaped by Catholic authoritarianism. In response to the 1940s anti-partition campaign, Shearman developed an apologia for the Stormont government as an essentially progressive technocracy, which he saw as culminating in the regime of Terence O'Neill. This article uses previously unexplored writings to track Shearman's life and career into the 1990s, when he is shown to have combined a view of the Irish question formed in the 1940s with a semi-conspiratorial unionist narrative of British betrayal.
Carbonate fabric diversity and environmental heterogeneity in the late Mesoproterozoic Era
Authors: Kah Linda C. , Bartley Julie K. 
Published: May 2021

AbstractTime-distinctive features within carbonate rocks, specifically the presence, abundance and distribution of stromatolites, molar-tooth fabric and specific morphologies of marine cement, have been identified as potential indicators of global-scale changes in the chemistry of marine environments. Recently, Cantineet al.(2019) introduced a database approach seeking to quantify spatial and temporal patterns in these carbonate features through the Precambrian. Despite the coarse temporal scale, results support earlier inferences of temporal change in carbonate sedimentation. Here, we use original field notes to dissect late Mesoproterozoic (˜1.3 to 1.0 Ga) carbonate strata at a high resolution, analyse time-distinctive carbonate fabrics within a database context and compare sedimentological patterns within this narrow time range to observations of the Proterozoic as a whole. Late Mesoproterozoic strata contain a variety of features (e.g. stromatolites, seafloor precipitates, herringbone carbonate, molar-tooth carbonate), often in close spatial and temporal proximity, that are commonly considered to be temporally restricted during the Precambrian. The spatial distribution of such features within Mesoproterozoic basins demonstrates the importance of recognizing even rare occurrences of time-distinctive facies and permits inference of environmental drivers that may have interacted to affect carbonate precipitation. Such spatial variability reflects a subtle division of Mesoproterozoic carbonate platform environments driven by globally high sea level, elevated carbonate saturation and a low-oxygen water column. The heterogeneous, mosaic nature of environments appears to be a hallmark of Mesoproterozoic carbonate sedimentation and emphasizes the importance of these basins in understanding longer-term trends in carbonate deposition.
Capsicum frutescens and Citrus limon: a new take on therapy against experimental trichinellosis
Authors: Salama Marwa Ahmed Mohamed , Mostafa Nahed E. , Abd El-Aal Naglaa Fathy , Mostafa Eman M. , Hammad Samar Kamel , Adel Rasha , Moawad Howayda Said Fouad 
Published: May 2021

Abstract
Trichinellosis is a zoonotic disease that endangers human health and can lead to death. Restricted absorption and poor results of conventional therapies demand new effective natural remedies to treat both enteral and parenteral trichinellosis. This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis. Overall, 50 Swiss albino male mice were divided into five groups, with ten mice in each group: negative control, positive control, albendazole combined with prednisolone, C. limon, and C. frutescens. Mice were sacrificed 7 and 35 days after infection, for intestinal and muscular phase analyses. Drug efficacies were parasitologically, biochemically, histopathologically and ultrastructurally assessed. Our results demonstrated the efficacy of C. frutescens and C. limon extracts as antiparasitic agents, showing a substantial decrease in adult and larval counts. Moreover, both extracts had the ability to decrease serum tumour necrosis factor-α levels during the intestinal and muscular phases. In addition to the improved histopathological changes in the small intestine and muscles, the destructive effects on adults and larvae were ultrastructurally evident on transmission electron microscopy. In conclusion, C. frutescens and C. limon extracts are promising remedies for the treatment of experimental trichinellosis, particularly, the C. frutescens extract.