bluuebunny/crossref_metadata_2025_split huggingface dataset:
A genome-wide association study of childhood adiposity and blood lipids
Authors: O'Nunain Katie , Sanderson Eleanor , Holmes Michael V , Davey Smith George , Richardson Tom G 
Published: November 2021

Background: The rising prevalence of childhood obesity and dyslipidaemia is a major public health concern due to its association with morbidity and mortality in later life. Methods: In this study, we have conducted genome-wide association studies (GWAS) for eight measures of adiposity and lipids in a cohort of young individuals (mean age 9.9) from the Avon Longitudinal Study of Parents and Children (ALSPAC). These measures were body mass index (BMI), systolic and diastolic blood pressure, high- density and low-density lipoprotein cholesterol, triglycerides, apolipoprotein A-I and apolipoprotein B. We next undertook functional enrichment, pathway analyses and linkage disequilibrium (LD) score regression to evaluate genetic correlations with later-life cardiometabolic diseases. Results: Using GWAS we identified 14 unique loci associated with at least one risk factor in this cohort of age 10 individuals (P<5x10-8), with lipoprotein lipid-associated loci being enriched for liver tissue-derived gene expression and lipid synthesis pathways. LD score regression provided evidence of various genetic correlations, such as childhood systolic blood pressure being genetically correlated with later-life coronary artery disease (rG=0.26, 95% CI=0.07 to 0.46, P=0.009) and hypertension (rG=0.37, 95% CI=0.19 to 0.55, P=6.57x10-5), as well as childhood BMI with type 2 diabetes (rG=0.35, 95% CI=0.18 to 0.51, P=3.28x10-5). Conclusions: Our findings suggest that there are genetic variants inherited at birth which begin to exert their effects on cardiometabolic risk factors as early as age 10 in the life course. However, further research is required to assess whether the genetic correlations we have identified are due to direct or indirect effects of childhood adiposity and lipid traits.
Impact of COVID-19 on non-COVID intensive care unit service utilization, case mix and outcomes: A registry-based analysis from India
Authors:   Indian Registry of IntenSive care (IRIS), KJ Adhikari Neill , Beane Abi , Devaprasad Dedeepiya , Fowler Robert , Haniffa Rashan , James Augustian , Jayakumar Devachandran , Kodippily Chamira , Aravindakshan Kooloth Rohit , Laxmappa Rakesh , Mangal Kishore , Mani Ashwin , Mathew Meghena , Pari Vrindha , Patodia Sristi , Pattnaik Rajyabardhan , Priyadarshini Dilanthi , Pulicken Mathew , Rabindrarajan Ebenezer , Ramachandran Pratheema , Ramesh Kavita , Rani Usha , Ramaiyan Ananth , Ramakrishnan Nagarajan , Ranganathan Lakshmi , Rashan Aasiyah , Dominic Savio Raymond , Selva Jaganathan , Tirupakuzhi Vijayaraghavan Bharath Kumar , Tripathy Swagata , Udayanga Ishara , Venkataraman Ramesh 
Published: November 2021

Background: Coronavirus disease 2019 (COVID-19) has been responsible for over 3.4 million deaths globally and over 25 million cases in India. As part of the response, India imposed a nation-wide lockdown and prioritized COVID-19 care in hospitals and intensive care units (ICUs). Leveraging data from the Indian Registry of IntenSive care, we sought to understand the impact of the COVID-19 pandemic on critical care service utilization, case-mix, and clinical outcomes in non-COVID ICUs. Methods: We included all consecutive patients admitted between 1 st October 2019 and 27 th September 2020. Data were extracted from the registry database and included patients admitted to the non-COVID or general ICUs at each of the sites. Outcomes included measures of resource-availability, utilisation, case-mix, acuity, and demand for ICU beds. We used a Mann-Whitney test to compare the pre-pandemic period (October 2019 - February 2020) to the pandemic period (March-September 2020). In addition, we also compared the period of intense lockdown (March-May 31 st 2020) with the pre-pandemic period. Results: There were 3424 patient encounters in the pre-pandemic period and 3524 encounters in the pandemic period. Comparing these periods, weekly admissions declined (median [Q1 Q3] 160 [145,168] to 113 [98.5,134]; p<0.001); unit turnover declined (median [Q1 Q3] 12.1 [11.32,13] to 8.58 [7.24,10], p<0.001), and APACHE II score increased (median [Q1 Q3] 19 [19,20] to 21 [20,22] ; p<0.001). Unadjusted ICU mortality increased (9.3% to 11.7%, p=0.015) and the length of ICU stay was similar (median [Q1 Q3] 2.11 [2, 2] vs. 2.24 [2, 3] days; p=0.151). Conclusion: Our registry-based analysis of the impact of COVID-19 on non-COVID critical care demonstrates significant disruptions to healthcare utilization during the pandemic and an increase in the severity of illness.
The genetic and epigenetic profile of serum S100β in the Lothian Birth Cohort 1936 and its relationship to Alzheimer’s disease
Authors: A Gadd Danni , I McGeachan Robert , F Hillary Robert , L McCartney Daniel , E Harris Sarah , A Sherwood Roy , Abbott N Joan , R Cox Simon , E Marioni Riccardo 
Published: November 2021

Background: Circulating S100 calcium-binding protein (S100β) is a marker of brain inflammation that has been associated with a range of neurological conditions. To provide insight into the molecular regulation of S100β and its potential causal associations with Alzheimer’s disease, we carried out genome- and epigenome-wide association studies (GWAS/EWAS) of serum S100β levels in older adults and performed Mendelian randomisation with Alzheimer’s disease. Methods: GWAS (N=769, mean age 72.5 years, sd = 0.7) and EWAS (N=722, mean age 72.5 years, sd = 0.7) of S100β levels were performed in participants from the Lothian Birth Cohort 1936. Conditional and joint analysis (COJO) was used to identify independent loci. Expression quantitative trait locus (eQTL) analyses were performed for lead loci that had genome-wide significant associations with S100β. Bidirectional, two-sample Mendelian randomisation was used to test for causal associations between S100β and Alzheimer’s disease. Colocalisation between S100β and Alzheimer’s disease GWAS loci was also examined. Results: We identified 154 SNPs from chromosome 21 that associated (P<5x10-8) with S100β protein levels. The lead variant was located in the S100β gene (rs8128872, P=5.0x10-17). We found evidence that two independent causal variants existed for both transcription of S100β and S100β protein levels in our eQTL analyses. No CpG sites were associated with S100β levels at the epigenome-wide significant level (P<3.6x10-8); the lead probe was cg06833709 (P=5.8x10-6), which mapped to the LGI1 gene. There was no evidence of a causal association between S100β levels and Alzheimer’s disease or vice versa and no evidence for colocalisation between S100β and Alzheimer’s disease loci. Conclusions: These data provide insight into the molecular regulators of S100β levels. This context may aid in understanding the role of S100β in brain inflammation and neurological disease.
Improving Column Generation for Vehicle Routing Problems via Random Coloring and Parallelization
Authors: Yu Miao , Nagarajan Viswanath , Shen Siqian 
Published: November 2021

We consider a variant of the vehicle routing problem (VRP) where each customer has a unit demand and the goal is to minimize the total cost of routing a fleet of capacitated vehicles from one or multiple depots to visit all customers. We propose two parallel algorithms to efficiently solve the column-generation-based linear-programming relaxation for this VRP. Specifically, we focus on algorithms for the “pricing problem,” which corresponds to the resource-constrained elementary shortest path problem. The first algorithm extends the pulse algorithm for which we derive a new bounding scheme on the maximum load of any route. The second algorithm is based on random coloring from parameterized complexity which can be also combined with other techniques in the literature for improving VRPs, including cutting planes and column enumeration. We conduct numerical studies using VRP benchmarks (with 50–957 nodes) and instances of a medical home care delivery problem using census data in Wayne County, Michigan. Using parallel computing, both pulse and random coloring can significantly improve column generation for solving the linear programming relaxations and we can obtain heuristic integer solutions with small optimality gaps. Combining random coloring with column enumeration, we can obtain improved integer solutions having less than 2% optimality gaps for most VRP benchmark instances and less than 1% optimality gaps for the medical home care delivery instances, both under a 30-minute computational time limit. The use of cutting planes (e.g., robust cuts) can further reduce optimality gaps on some hard instances, without much increase in the run time. Summary of Contribution: The vehicle routing problem (VRP) is a fundamental combinatorial problem, and its variants have been studied extensively in the literature of operations research and computer science. In this paper, we consider general-purpose algorithms for solving VRPs, including the column-generation approach for the linear programming relaxations of the integer programs of VRPs and the column-enumeration approach for seeking improved integer solutions. We revise the pulse algorithm and also propose a random-coloring algorithm that can be used for solving the elementary shortest path problem that formulates the pricing problem in the column-generation approach. We show that the parallel implementation of both algorithms can significantly improve the performance of column generation and the random coloring algorithm can improve the solution time and quality of the VRP integer solutions produced by the column-enumeration approach. We focus on algorithmic design for VRPs and conduct extensive computational tests to demonstrate the performance of various approaches.
Invasão ou ocupação? a estratégia argumentativa do Poder Judiciário nas decisões envolvendo o ingresso em imóveis abandonados
Authors: Moura Renata Helena Paganoto , Coura Alexandre De Castro 
Published: November 2021

Nas ações judiciais sobre o ingresso em imóveis abandonados verificou-se conclusões diferentes: ora a propriedade abandonada ‘autoriza’ o ingresso para moradia, ora ‘não autoriza’. Ora são invasores, ora são ocupantes. O presente artigo busca compreender como, num sistema de regras explícitas, há tantas decisões contraditórias, sobre o mesmo fato. A dialética se apresenta como método, através de uma abordagem jurisprudencial e teórica, tendo como ponto de partida a distinção entre o senso comum teórico dos juristas e o saber crítico proposta por Warat e sua crítica à epistemologia dos conceitos e a análise realizada por Katharina Sobota do silogismo enquanto estilo de apresentação da decisão judicial. Como resultado concluiu-se que o senso comum teórico dos juristas esconde esse jogo estratégico do discurso; a decisão é construída para dar uma sensação de completude e coerência lógica, deixando de revelar que o que move a interpretação dessas ações ora é a defesa intransigente de uma propriedade liberal, em que esse proprietário é o senhor absoluto dos poderes que lhe são atribuídos por lei; ora é a defesa da função social, mas, apesar de muitos avanços, o terreno político atual corrobora para manutenção da primeira.
Changes in the microbiological diagnosis and epidemiology of cutaneous leishmaniasis in real-time PCR era: A six-year experience in a referral center in Barcelona
Authors: Silgado Aroa , Armas Mayuli , Sánchez-Montalvá Adrián , Goterris Lidia , Ubals Maria , Temprana-Salvador Jordi , Aparicio Gloria , Chicharro Carmen , Serre-Delcor Núria , Ferrer Berta , Molina Israel , García-Patos Vicenç , Pumarola Tomas , Sulleiro Elena 
Published: November 2021

Background
Leishmaniasis is a neglected disease caused by different species of the protozoa Leishmania spp. Cutaneous lesions are the most common clinical manifestation. This disease is prevalent in tropical and subtropical areas, including the Mediterranean basin. In Spain, Leishmania (L.) infantum is the only endemic species, but imported cases are often diagnosed. Different classical parasitological methods can be performed for cutaneous leishmaniasis (CL) diagnosis; but currently molecular techniques serve as a relevant tool for the detection and characterization of Leishmania parasites. We aimed to evaluate clinical and epidemiological characteristics of CL diagnosed patients by real-time PCR in a tertiary hospital over a six-year period.

Methodology/Principal findings
Clinical, epidemiological and microbiological data were retrospectively collected and analyzed. In our study, CL was confirmed in 59 (31.4%) out of 188 patients by real-time PCR, showing an increase over recent years: 11 cases of CL between 2014 and 2016 and 48 between 2017 and 2019. Real-time PCR was performed on skin swabs and/or biopsies samples, with a positivity of 38.5% and 26.5%, respectively. Results were 100% concordant when biopsy and skin swab were performed simultaneously. L. (L.) infantum was the most frequent species detected (50%), followed by L. (L.) major (45%) and Viannia subgenus (5%), which were detected only in imported cases. L. (L.) major was almost entirely detected in travelers/migrants from Morocco. Multiple and atypical skin lesions were more common in imported cases than in autochthonous cases (44.4% vs. 21.8%).

Conclusions/Significance
An increase in both autochthonous and imported CL cases has been observed in past years in our hospital. Molecular techniques assist in improving CL diagnosis and characterization of the Leishmania species, mainly in imported cases.
The effects of resistance training with blood flow restriction on muscle strength, muscle hypertrophy and functionality in patients with osteoarthritis and rheumatoid arthritis: A systematic review with meta-analysis
Authors: dos Santos Leonardo Peterson , Santo Rafaela Cavalheiro do Espírito , Ramis Thiago Rozales , Portes Juliana Katarina Schoer , Chakr Rafael Mendonça da Silva , Xavier Ricardo Machado 
Published: November 2021

Introduction
Rheumatoid arthritis(RA) and osteoarthritis(OA) patients showed systemic manifestations that may lead to a reduction in muscle strength, muscle mass and, consequently, to a reduction in functionality. On the other hand, moderate intensity resistance training(MIRT) and high intensity resistance training(HIRT) are able to improve muscle strength and muscle mass in RA and OA without affecting the disease course. However, due to the articular manifestations caused by these diseases, these patients may present intolerance to MIRT or HIRT. Thus, the low intensity resistance training combined with blood flow restriction(LIRTBFR) may be a new training strategy for these populations.

Objective
To perform a systematic review with meta-analysis to verify the effects of LIRTBFR on muscle strength, muscle mass and functionality in RA and OA patients.

Materials and methods
A systematic review with meta-analysis of randomized clinical trials(RCTs), published in English, between 1957–2021, was conducted using MEDLINE(PubMed), Embase and Cochrane Library. The methodological quality was assessed using Physiotherapy Evidence Database scale. The risk of bias was assessed using RoB2.0. Mean difference(MD) or standardized mean difference(SMD) and 95% confidence intervals(CI) were pooled using a random-effects model. A P<0.05 was considered statistically significant.

Results
Five RCTs were included. We found no significant differences in the effects between LIRTBFR, MIRT and HIRT on muscle strength, which was assessed by tests of quadriceps strength(SMD = -0.01[-0.57, 0.54], P = 0.96; I² = 58%) and functionality measured by tests with patterns similar to walking(SMD = -0.04[-0.39, 0.31], P = 0.82; I² = 0%). Compared to HIRT, muscle mass gain after LIRTBFR was reported to be similar. When comparing LIRTBFR with low intensity resistance training without blood flow restriction(LIRT), the effect LIRTBFR was reported to be higher on muscle strength, which was evaluated by the knee extension test.

Conclusion
LIRTBFR appears to be a promising strategy for gains in muscle strength, muscle mass and functionality in a predominant sample of RA and OA women.
Response of onion crop to bulb set size and planting date under mulching in dry Mediterranean environment
Authors: MUBARAK Ibrahim 
Published: November 2021

The present pot experiment under open field conditions was conducted to evaluate the response of onion crop to bulb set size and planting date using mulching. Two different sizes of onion sets at planting (large (6-10 g) and small (2-6 g)) and three different planting dates (February, March, and April) with two soil coverings (with and without straw mulching) were tested. Treatments were replicated three times. Onion was not exposed to any drought stress during the course of the experiment.Results indicated that the larger bulb sets which were planted earlier under mulching, maximised the total bulb yield (Yield, 44.0 t ha-1), water use efficiency (WUE, 8.37 kg m-3), and irrigation water use efficiency (IWUE, 9.57 kg m-3). Moreover, findings revealed that onion crop appreciably respond to smaller bulb sets when they were planted earlier under mulching. Onion bulb responses were predicted to be linearly increased with the earliness in planting date, with an obvious better preference under mulching and heavier bulb sets. Hence, adopting early planting date with mulching is suggested for sustainable crop production and for enhancing water use efficiency in dry Mediterranean area.
Compare of Food Habit and Nutritional Status of Rural Male and Female
Authors: Rahman Redwan , Sheema Mahfuza Khanom 
Published: November 2021

ABSTRACT
There is a big difference between male and female in the rural environment of Bangladesh and the aim of this eating habits and nutritional status. The study was conducted through 384 respondents from 9 villages in Ishwardi, Pabna; a north-western district of Bangladesh. The research has done on the food habits of the middle and lower class people of the villages. And some informations are collected from the different sources. In the research 73.44% of male earn more than 24 thousand BDT per month when only 43.32% female are earning more than 24 thousand BDT. Most of the female are housewives and male are service holder. 44.79% male are service holder on the other hand 4.69% female are service holder. Rice is the main food for Bangladesh. So, most of the people have rice on daily three times. 37.80% of female and 66.98% of male are having rice. Ruti is the second priority food, female take this food 0.56% and male take 7.55% for 2 days. 63.33% female take egg, on the other hand 58.07% male take egg per week. 3.2% female her meal last of all and 1.5% female take it first of all. On the other hand 6.25% male take their meal first of all and 3.39% male take their meal last of all. Most of the female are normal having BMI 89.06% on the other hand male are overweight 78.18%. In the light of the study the eating habits of male and female in Bangladesh have improved but it has not yet affected everyone.
Treatment of Age-Related Hearing Loss Alters Audiovisual Integration and Resting-State Functional Connectivity: A Randomized Controlled Pilot Trial
Authors: Rosemann Stephanie , Gieseler Anja , Tahden Maike , Colonius Hans , Thiel Christiane M. 
Published: November 2021

AbstractUntreated age-related hearing loss increases audiovisual integration and impacts resting state functional brain connectivity. Further, there is a relation between crossmodal plasticity and audiovisual integration strength in cochlear implant patients. However, it is currently unclear whether amplification of the auditory input by hearing aids influences audiovisual integration and resting state functional brain connectivity. We conducted a randomized controlled pilot study to investigate how the McGurk illusion, a common measure for audiovisual integration, and resting state functional brain connectivity of the auditory cortex are altered by six-month hearing aid use. Thirty-two older participants with slight-to-moderate, symmetric, age-related hearing loss were allocated to a treatment or waiting control group and measured one week before and six months after hearing aid fitting with functional magnetic resonance imaging. Our results showed a statistical trend for an increased McGurk illusion after six months of hearing aid use. We further demonstrated that an increase in McGurk susceptibility is related to a decreased hearing aid benefit for auditory speech intelligibility in noise. No significant interaction between group and time point was obtained in the whole-brain resting state analysis. However, a region of interest (ROI)-to-ROI analysis indicated that hearing aid use of six months was associated with a decrease in resting state functional connectivity between the auditory cortex and the fusiform gyrus and that this decrease was related to an increase of perceived McGurk illusions. Our study, therefore, suggests that even short-term hearing aid use alters audiovisual integration and functional brain connectivity between auditory and visual cortices.
Microstructure and properties of TiB2-reinforced Ti–35Nb–7Zr–5Ta processed by laser-powder bed fusion
Authors: Batalha Rodolfo Lisboa , Pinotti Vitor Eduardo , Alnoaimy Omar O. S. , Batalha Weverson Capute , Gustmann Tobias , Kosiba Konrad , Pauly Simon , Bolfarini Claudemiro , Kiminami Claudio Shyinti , Gargarella Piter 
Published: November 2021

AbstractThe Ti–35Nb–7Zr–5Ta (wt%, TNZT) alloy was reinforced with TiB2 and synthesized by L-PBF. The relatively small TiB2 particles change the solidification structure from cellular to columnar-dendritic and lead to submicron TiB precipitation in the β matrix. This results in pronounced grain refinement and reduction of texture. However, the microstructure of the additively manufactured TNZT-TiB2 is still different from the as-cast, unreinforced TNZT, which contains equiaxed and randomly oriented grains. The β phase is less stable in the as-cast samples, leading to stress-induced martensitic transformation and recoverable strain of 1.5%. The TNZT with 1 wt% of TiB2 presents significantly higher compressive strength (σYS = 495 MPa) compared to unreinforced samples (σYS = 430 MPa), without sacrificing ductility or altering Young’s modulus (E ≈ 46 GPa). The addition of a small fraction of TiB2 to the TNZT alloy synthesized by L-PBF is a promising alternative for manufacturing sophisticated components for biomedical applications.
Graphical abstract
Proton irradiation-induced blistering in UO2
Authors: Pakarinen Janne , He Lingfeng , Gan Jian , Nelson Andrew T. , El-Azab Anter , Khafizov Marat , Allen Todd R. 
Published: November 2021

AbstractProton (H+) irradiation effects in polycrystalline UO2 have been studied. The irradiation was carried out using three ion energies and two different ion fluxes at 600 °C. Scanning electron microscopy (SEM) investigations showed that significant surface flaking took place. Focused ion beam (FIB) milling in SEM was successfully applied for extracting lamellas from uneven blistered surfaces for transmission electron microscopy (TEM) investigations allowing detailed investigations for the degradation mechanisms. High-resolution TEM for the flaked UO2 surfaces revealed that the implanted H+ formed sharp two-dimensional cavities at the peak ion-stopping region instead of diffusing to the matrix. The resulting lateral stress likely caused UO2 surface deterioration in good agreement with previous blistering and flaking studies on crystalline materials.
Graphical abstract