bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cooperativity and Anticooperativity in Ion‐Water Interactions: Implications for the Aqueous Solvation of Ions
Authors: Sauza‐de la Vega Arturo , Rocha‐Rinza Tomás , Guevara‐Vela José Manuel 
Published: February 2021

AbstractNon‐additive effects in hydrogen bonds (HB) take place as a consequence of electronic charge transfers. Therefore, it is natural to expect cooperativity and anticooperativity in ion‐water interactions. Nevertheless, investigations on this matter are scarce. This paper addresses the interactions of (i) the cations Li+, Na+, K+, Be2+, Mg2+, and Ca2+together with (ii) the anions F−, Cl−, Br−, NO3−and SO42−with water clusters (H2O)n, n=1–8, and the effects of these ions on the HBs within the complete molecular adducts. We used quantum chemical topology tools, specifically the quantum theory of atoms in molecules and the interacting quantum atoms energy partition to investigate non‐additive effects among the interactions studied herein. Our results show a decrease on the interaction energy between ions and the first neighbouring water molecules with an increment of the coordination number. We also found strong cooperative effects in the interplay between HBs and ion‐dipole interactions within the studied systems. Such cooperativity affects considerably the interactions among ions with their first and second solvation shells in aqueous environments. Overall, we believe this article provides valuable information about how ion‐dipole contacts interact with each other and how they relate to other interactions, such as HBs, in the framework of non‐additive effects in aqueous media.
User‐driven supply chain business model innovation: The role of dynamic capabilities
Authors: Sun Yanhua , Gong Yu , Zhang Yufang , Jia Fu , Shi Yangyan 
Published: February 2021

AbstractThis research explores how focal tea companies facilitate supply chain business model innovation (SCBMI) to meet consumer demands and achieve sustainable development. By applying a case study method and dynamic capability theory, we find that: (1) the end‐user innovation‐driven is the precondition for tea SCBMI; (2) the user‐driven innovation leads to the change of the supply chain focal company dynamic capabilities and the tea supply chain network structure, and thus promote the tea SCBMI; (3) SCBMI will, in turn, enhance the focal company's dynamic capabilities and promote the change of tea supply chain network structure in order to meet the consumers' changing demands. Our research suggests that the supply chain should pay attention to the construction of dynamic capabilities and proactively manage supply chain network structure. Ultimately, the entire supply chain business model will continuously adapt to the external changes and achieve sustainable development in the long term.
The influence of green trust on travel agency intentions to promote low‐carbon tours for the purpose of sustainable development
Authors: Sung Pei Ling , Hsiao Teng Yuan , Huang Leo , Morrison Alastair M. 
Published: February 2021

AbstractThrough corporate social responsibility, tourism companies can contribute to sustainable development by embracing concepts such as low‐carbon tourism and environmental protection. The purpose of this research was to determine the intention of Taiwanese travel agencies to promote low‐carbon tours by incorporating government‐approved eco‐friendly travel products. In total, 427 valid questionnaires were collected and examined by means of PLS‐SEM. The findings showed that green trust not only had a significant and direct impact on intentions to sell low‐carbon tours, but also influenced agency attitudes, subjective norms, and perceived behavioral control. The study also demonstrated that the TPB was appropriate for predicting intentions for green decision‐making at an organizational level and that subjective norms (e.g., peers, customers) influenced by green trust displayed more predictive strength (53.4%). The findings provide a method for incorporating low‐carbon tourism into the travel industry.
Deciphering DSC2 arrhythmogenic cardiomyopathy electrical instability: From ion channels to ECG and tailored drug therapy
Authors: Moreau Adrien , Reisqs Jean‐Baptiste , Delanoe‐Ayari Helene , Pierre Marion , Janin Alexandre , Deliniere Antoine , Bessière Francis , Meli Albano C. , Charrabi Azzouz , Lafont Estele , Valla Camille , Bauer Delphine , Morel Elodie , Gache Vincent , Millat Gilles , Nissan Xavier , Faucherre Adele , Jopling Chris , Richard Sylvain , Mejat Alexandre , Chevalier Philippe 
Published: February 2021

AbstractBackgroundSevere ventricular rhythm disturbances are the hallmark of arrhythmogenic cardiomyopathy (ACM), and are often explained by structural conduction abnormalities. However, comprehensive investigations of ACM cell electrical instability are lacking. This study aimed to elucidate early electrical myogenic signature of ACM.MethodsWe investigated a 41‐year‐old ACM patient with a missense mutation (c.394C>T) in the DSC2 gene, which encodes desmocollin 2. Pathogenicity of this variant was confirmed using a zebrafish DSC2 model system. Control and DSC2 patient‐derived pluripotent stem cells were reprogrammed and differentiated into cardiomyocytes (hiPSC‐CM) to examine the specific electromechanical phenotype and its modulation by antiarrhythmic drugs (AADs). Samples of the patient's heart and hiPSC‐CM were examined to identify molecular and cellular alterations.ResultsA shortened action potential duration was associated with reduced Ca2+ current density and increased K+ current density. This finding led to the elucidation of previously unknown abnormal repolarization dynamics in ACM patients. Moreover, the Ca2+ mobilised during transients was decreased, and the Ca2+ sparks frequency was increased. AAD testing revealed the following: (1) flecainide normalised Ca2+ transients and significantly decreased Ca2+ spark occurrence and (2) sotalol significantly lengthened the action potential and normalised the cells’ contractile properties.ConclusionsThorough analysis of hiPSC‐CM derived from the DSC2 patient revealed abnormal repolarization dynamics, prompting the discovery of a short QT interval in some ACM patients. Overall, these results confirm a myogenic origin of ACM electrical instability and provide a rationale for prescribing class 1 and 3 AADs in ACM patients with increased ventricular repolarization reserve.
Aptamer‐SH2 superbinder‐based targeted therapy for pancreatic ductal adenocarcinoma
Authors: Liu An‐Dong , Zhou Jie , Bi Xiao‐Yang , Hou Guo‐Qing , Li Shawn Shun‐Cheng , Chen Qing , Xu Hui , Cao Xuan 
Published: February 2021

AbstractBackgroundPancreatic ductal adenocarcinoma (PDAC) exhibits the poorest prognosis of all solid tumors with a 5‐year survival rate of less than 10% and a median survival of 6 months after diagnosis. Numerous targeted agents have been developed and evaluated to improve the survival benefit in patients with PDAC. Unfortunately, most agents have been proven futile mainly owing to the dense stroma and the sophisticated signaling pathways of PDAC. Here, we show the potent effectiveness of Aptamer‐SH2 superbinder‐(Arg)9 conjugate on the treatment of PDAC. In this conjugate, DNA aptamer selected against PDAC cell line confers the function of specifically recognizing and binding to the PDAC cells and activated pancreatic stellate cells (PSCs) in stroma; cell penetrating peptide (Arg)9 facilitates the intracellular delivery of fused proteins; SH2 superbinder conducts the drastic blockade of multiple phosphotyrosines (pY)‐based signaling pathways in tumor cells.MethodsPDAC‐associated pY were reanalyzed by bioinformatics screen. XQ‐2d and SH2 superbinder‐(Arg)9 were crosslinked with BMH to form XQ‐2d‐SH2 CM‐(Arg)9 conjugate. Immunofluorescence was utilized to assess the potency of the conjugate entering cells. MTT and wound healing assays were performed to evaluate the proliferation or migration of PANC‐1 and BxPC‐3 cells, respectively. Western blot and Pulldown assays revealed that conjugate influenced several pY‐based signaling pathways. Tumor‐bearing mice were used to validate XQ‐2d‐SH2 CM‐(Arg)9, which restrained the growth and metastasis of cancer cells.ResultsXQ‐2d‐His‐SH2 CM‐(Arg)9 conjugate restrained proliferation, invasion, and metastasis of PDAC cells with potent efficacy via blocking the activity of several pY‐related signaling cascades. XQ‐2d‐His‐SH2 CM‐(Arg)9 could eliminate the dense stroma of PDAC and then arrive at tumor tissues.ConclusionsXQ‐2d‐SH2 CM‐(Arg)9 conjugate may efficiently destroy the pancreatic stroma and show potent antitumor efficacy with minimal toxic effect by regulating tumor cell proliferation and metastasis in vitro and in vivo, which makes it to be a promising targeted therapy of PDAC.
Optimal relay and channel selection schemes for multiconstrained QoS multicast routing in cognitive radio ad hoc networks
Authors: Indumathi G. , Vaithianathan V. 
Published: February 2021

SummaryDuring multicasting in cognitive radio ad hoc network (CRAHN), apart from energy consumption, interchannel interference, path delay, and channel switching delay should be minimized. The channel selection should be done, based on spectrum opportunities and channel quality. Hence, the multicast routing problem becomes a multiconstrained QoS routing problem. This paper proposes optimal relay and channel selection schemes (ORCS) for multiconstrained QoS multicast routing in CRAHNs. For multicast tree construction, distributed minimum spanning tree (DMST) is used. For meeting the delay, energy, and interference constraints, relay nodes are chosen with minimum path delay, less energy consumption, and minimum interference. For effective channel assignment, channels with good channel quality, maximum spectrum accessibility, and sufficient common slots are selected. By simulation results, it has been shown that the proposed ORCS minimize the energy consumption and end‐to‐end delay.
Getting under the skin: Physiological stress and witnessing paternal arrest in young children with incarcerated fathers
Authors: Muentner Luke , Kapoor Amita , Weymouth Lindsay , Poehlmann‐Tynan Julie 
Published: February 2021

AbstractU.S. jails see nearly 11 million annual admissions, rates that disproportionately affect men of color—more than half of whom are fathers. An estimated 7% of U.S. children experience the incarceration of a parent, increasing their risk for poor developmental and health outcomes. Although stress processes are often suggested as an underlying mechanism linking paternal incarceration to child well‐being, few studies have examined such links. To study how witnessing a father's arrest prior to incarceration in jail relates to children's stress processes, we collected data on 123 individuals from 41 families with young children whose father was in jail, including collecting hair from 41 children, and analyzed their cumulative stress hormones, cortisol, and cortisone. Results indicate that children had higher cumulative stress hormone concentrations when they witnessed their father's arrest. Moreover, there was evidence of a blunted stress reaction in children who witnessed the arrest and who also had high levels of ongoing behavioral stress symptoms, similar to findings in Post‐Traumatic Stress Disorder studies. Long‐term exposure to stress can have deleterious effects on children's brain development, further increasing risk for developmental psychopathology. Findings have implications for criminal justice approaches that safeguard children during parental arrest.
Simultaneous testing for anabolic steroids in human hair specimens collected from various anatomic locations has several advantages when compared with the standard head hair analysis
Authors: Kintz Pascal , Gheddar Laurie , Raul Jean‐Sébastien 
Published: February 2021

AbstractSince the late 90s, hair testing for anabolic steroids in humans has found numerous forensic, clinical, and anti‐doping applications. In most cases, analyses were performed on head hair, collected in the vertex regions. However, for various reasons (shaved subject, bald subject, religious belief, cosmetic treatment and aesthetic reason), hair collectors can face the lack of head hair, and therefore, body hair can be the unique alternative choice. Although there is no possibility to perform segmental analyses with body hair, their use has two major advantages: (1) In most cases, anabolic steroids are more concentrated in body hair when compared with head hair, which allows detecting abuse at lower frequency and for lower dosages; and (2) the window of drug detection is generally much longer in body hair when compared with head hair, particularly in male athlete presenting short head hair. To document the relevance of simultaneous collection of head and body hair, the authors present eight authentic cases of anabolic steroids abuse, including clostebol (one case), drostanolone (one case), metandienone (one case), 19‐norandrostenedione (one case), stanozolol (two cases) and trenbolone (three cases). In all cases, body hair concentrations were higher than head hair concentrations. Even in three cases, no steroid was identified in head hair, although present in body hair.
Lithium Hydroxide AssistedEndo‐Selective [4+4]‐Photocycloaddition of Pyran‐2‐ones
Authors: Li Lei , Turnbull William L. , McDonald Robert , West F. G. 
Published: February 2021

Abstract3‐Acyl‐4‐hydroxypyan‐2‐ones with pendent furans, readily available from dehydroacetic acid, are substrates for intramolecular [4+4]‐photocycloaddition. In the presence of stoichiometric lithium base, these substrates undergo conversion to lactone‐bridged cyclooctenones in moderate to good yields upon irradiation in THF at 0 °C. In contrast to other crossed [4+4]‐photocycloadditions of pyran‐2‐ones, these examples proceed with complete diastereoselectivity for theendocycloadducts.
Analysis of the synergistic effects of air pollutant emission reduction and carbon emissions at coal‐fired power plants in China
Authors: Du Lili , Zhao Haijun , Tang Haoyue , Jiang Ping , Ma Weichun 
Published: February 2021

AbstractDue to ongoing urbanization and industrialization, the energy and electricity demand and consumption are rapidly growing in China, resulting in large air pollutant and greenhouse gas emissions. The coal‐fired power industry is a key to achieving synergistic reduction of air pollutant and carbon emissions. This paper quantifies and compares synergistic effects of technology and policy reduction measures in the coal‐fired power industry. Using 2158 coal‐fired power generators of different types at 833 coal‐fired power plants in 24 Chinese provinces as research samples, this study quantifies and assesses the synergistic effects of structural and technical emission reductions at coal‐fired power plants through top‐down analysis of structural emission reduction and bottom‐up analysis of technical emission reduction. Comparing the synergy coefficients of both types of emission reduction measures, it is determined that structural emission reduction has a significant positive synergistic effect on energy consumption, pollutant and carbon emissions, with no extra emissions and energy consumption. On the other hand, technical emission reduction results in the negative synergistic effect of CO2 emissions due to electric power consumption and chemical reactions emissions in end‐of‐pipe measures of emission control, which demonstrated that prevalent desulfurization measure WFDG synergistically led to 0.688 tons of CO2 and 5.132 MWh electric power consumption for 1 ton of SO2 removed. Therefore, the structural emission reduction is an important means for multi‐target energy conservation and emission reduction. It is necessary for technical emission reduction to reduce related negative synergistic effects while enhancing target pollutant removal.
Unbalanced intakes of sodium and potassium among Tunisian adults: A cross‐sectional study
Authors: Doggui Radhouene , El Ati Jalila , Sassi Sonia , Ben Gharbia Houda , Al‐Jawaldeh Ayoub , El Ati‐Hellal Myriam 
Published: February 2021

AbstractThe prevention and management of hypertension are untimely associated with a lowering of sodium intake. The present study aimed to evaluate the sodium and potassium intake levels of Tunisian population through measurement of 24‐hr urinary sodium excretions. A randomly, multistage, cross‐sectional study was conducted in an urban region (Bizerte) in Tunisia during 2015. The target population involved adults aged from 25 to 64 years. Sodium, potassium, and creatinine concentrations were determined in each urine sample using indirect potentiometric method. From the 420 selected participants, only 194 gave urine samples complying completeness criteria. A multivariate regression model was used to assess the variables related to sodium and potassium excretion. The daily mean excretion of sodium and potassium was 138.3 ± 46.5 mmol/d (corresponding to 8.1 ± 2.7 g/d of salt intake) and 61.0 ± 22.7 mmol/d, respectively. More than 87.1% of the participants (89.8% for men vs. 84.9% for women; p = .31) exceeded the WHO recommendation of 5 g/d. The upper limit of 10 g salt intake per day was still exceeded by 26.3%. After adjusted analysis, sex (for women, coef = −1.6; (95% CI: −2.4, −0.7)), level of instruction (≥30 kg/m2, coef = +1.1; (95% IC: 0.4–2.0)), and body mass index (≥30 kg/m2, coef = +1.1; (95% CI: 0.1, 2.0)) were associated with the sodium excretion. High sodium intake and inadequate potassium intake were found among participants. This consumption profile complies with the diet westernization context occurring in Tunisia. The initiated strategy focused on the downward of sodium in bread (the main source of salt intake) seems to be promising.
Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α
Authors: Ren Huihui , Hu Fuqing , Wang Dan , Kang Xiaonan , Feng Xiaohui , Zhang Lu , Zhou Bowen , Liu Siyue , Yuan Gang 
Published: February 2021

Background and Aims
Sirtuin 2 (SIRT2), an NAD+‐dependent deacetylase, is involved in various cellular processes regulating metabolic homeostasis and inflammatory responses; however, its role in hepatic steatosis and related metabolic disorders is unknown.

Approach and Results
Integrating the published genomic data on NAFLD samples from humans and rodents available in the Gene Expression Omnibus, we found that SIRT2 was significantly down‐regulated in livers from patients with advanced NAFLD and high‐fat diet (HFD)–induced NAFLD mice. This study further revealed that SIRT2 was markedly decreased in obese (ob/ob) mice and in palmitate‐treated HepG2 cells. Restoration of hepatic SIRT2 expression in ob/ob or HFD‐fed mice largely alleviated insulin resistance, hepatic steatosis, and systematic inflammation, whereas SIRT2 liver‐specific ablation exacerbated these metabolic dysfunctions in HFD‐fed C57BL/6J mice. Mechanistically, SIRT2 stabilized the hepatocyte nuclear factor 4α (HNF4α) protein by binding to and deacetylating HNF4α on lysine 458. Furthermore, HNF4α was sufficient to mediate SIRT2 function, and SIRT2‐HNF4α interaction was required for SIRT2 function both in vivo and in vitro.

Conclusions
Collectively, the present study provided evidence that SIRT2 functions as a crucial negative regulator in NAFLD and related metabolic disorders and that targeting the SIRT2‐HNF4α pathway may be a promising strategy for NAFLD treatment.
Male Sex Is Associated With Higher Rates of Liver‐Related Mortality in Primary Biliary Cholangitis and Cirrhosis
Authors: John Binu V. , Aitcheson Gabriella , Schwartz Kaley B. , Khakoo Nidah S. , Dahman Bassam , Deng Yangyang , Goldberg David , Martin Paul , Taddei Tamar H. , Levy Cynthia , Kaplan David E. 
Published: February 2021

Background and Aims
The impact of sex on the postcirrhosis progression of primary biliary cholangitis (PBC) has not been well defined. Prior studies have suggested that men have worse outcomes but present at more advanced stages of fibrosis than women. This observation, however, has been limited by small numbers of men and even fewer patients with cirrhosis.

Approach and Results
We investigated the association of sex with the development of all‐cause and liver‐related mortality or transplantation, decompensation, and hepatocellular carcinoma (HCC), using competing‐risk time‐updating Cox proportional hazards models in a large cohort of predominantly male patients with PBC cirrhosis assembled from the Veterans Health Administration. In a cohort of 532 participants (418 male) with PBC‐related cirrhosis with a total follow‐up of 3,231.6 person‐years (PY) from diagnosis of compensated cirrhosis, male participants had a higher unadjusted rates of death or transplantation (8.5 vs. 3.8 per 100 PY; P < 0.0001), liver‐related death or transplantation (5.5 vs. 2.7 per 100 PY; P < 0.0001), decompensation (5.5 vs. 4.0 per 100 PY; P = 0.002), and HCC (0.9 vs. 0.3 per 100 PY; P < 0.0001). After adjusting for confounders, male sex was associated with a higher risk of death or transplantation (adjusted hazard ratio, 1.80; 95% CI, 1.01‐3.19; P = 0.046), and liver‐related death or transplantation (subhazard ratio, 2.17; 95% CI, 1.15‐4.08; P = 0.02). A sensitivity analysis that defined ursodeoxycholic acid response as normalization of alkaline phosphatase and total bilirubin revealed similar findings.

Conclusions
In patients with PBC and well‐compensated cirrhosis, male sex is associated with a higher risk of both death and liver‐related death or transplantation.
Double‐diffusive natural convective stream due to moving vertical plate with nonlinear thermal radiation and Newton's boundary constraint
Authors: Nandeppanavar Mahantesh M. , Kemparaju M. C. , Nagaraj Raveendra 
Published: February 2021

AbstractThis article investigates the heat and mass transmission of the double‐diffusive convective stream over a moving vertical plate with nonlinear thermal radiation and newton boundary conditions. The governing partial differential equations of the stream, heat, and concentration profiles were transformed into a system of nonlinear ordinary differential equation by utilizing resemblance transformation. This system was then resolved numerically by applying the fourth order Runge‐Kutta method with most efficient shooting technique. The effect of convection, buoyancy ratio, nonlinear thermal radiation, Prandtl number, Rayleigh number and Schmidt number are graphically scrutinized. The numerical results are obtained for velocity, temperature, and concentration profiles. It is found that when the velocity profile increases, heat and mass transfer rate decreases with an increase in the parametric value of buoyancy ratio parameter. It is found that the effect of nonlinear thermal radiation stabilizes the thermal boundary layer growth. The skin friction coefficient decreases with an increase in Prandtl number. However, the Nusselt number increases with an increase in the local convective heat transfer rate. The present results are very much promising, and further, there is a very good agreement of results when compared with earlier published results for some limiting conditions.