bluuebunny/crossref_metadata_2025_split huggingface dataset:
DILI-Stk: An Ensemble Model for the Prediction of Drug-induced Liver
Injury of Drug Candidates
Authors: Lee Jingyu , Yu Myeong-Sang , Na Dokyun 
Published: December 2021

Background:
Drug-induced liver injury (DILI) is a leading cause of drug failure, accounting
for nearly 20% of drug withdrawal. Thus, there has been a great demand for in silico DILI prediction
models for successful drug discovery. To date, various models have been developed for DILI prediction;
however, building an accurate model for practical use in drug discovery remains challenging.

Methods:
We constructed an ensemble model composed of three high-performance DILI prediction
models to utilize the unique advantage of each machine learning algorithm.

Results:
The ensemble model exhibited high predictive performance, with an area under the curve of
0.88, sensitivity of 0.83, specificity of 0.77, F1-score of 0.82, and accuracy of 0.80. When a test dataset
collected from the literature was used to compare the performance of our model with publicly available
DILI prediction models, our model achieved an accuracy of 0.77, sensitivity of 0.82, specificity of 0.72,
and F1-score of 0.79, which were higher than those of the other DILI prediction models. As many published
DILI prediction models are not available for public access, which hinders in silico drug discovery,
we made our DILI prediction model publicly accessible (http://ssbio.cau.ac.kr/software/dili/).

Conclusion:
We expect that our ensemble model may facilitate advancements in drug discovery by
providing a highly predictive model and reducing the drug withdrawal rate.
Cytotoxic Evaluation and Molecular Docking Studies of Aminopyridine Derivatives
as Potential Anticancer Agents
Authors: Ilyas Umair , Alkury Lina Tariq , Naaz Shagufta , Muhammad Syed Aun , Nadeem Humaira , Altaf Reem , Zaman Shahiq uz , Faheem Muhammad , Sajid Imran , Cheema Mohsin Tasawar , Mannan Abdul , Shah Fawad Ali , Li Shupeng 
Published: December 2021

Background:
The development of resistance to available anticancer drugs is increasingly becoming a major
challenge and new chemical entities could be unveiled to compensate for this therapeutic failure.

Objectives:
The current study demonstrated whether N-protected and deprotected amino acid derivatives of 2-
aminopyridine could attenuate tumor development using colorectal cancer cell lines.

Methods:
Biological assays were performed to investigate the anticancer potential of synthesized compounds. The in silico ADME profiling and docking studies were also performed by docking the designed compounds against the active binding site of beta-catenin (CTNNB1) to analyze the binding mode of these compounds. Four derivatives 4a, 4b, 4c, and 4d were selected for investigation of in vitro anticancer potential using colorectal cancer cell line HCT 116. The anti-tumor activities of synthesized compounds were further validated by evaluating the inhibitory effects of these compounds on the target protein beta-catenin through in vitro enzyme inhibitory assay.

Results:
Biological assays were performed to investigate the anticancer potential of synthesized compounds. The in
silico ADME profiling and docking studies were also performed by docking the designed compounds against the active
binding site of beta-catenin (CTNNB1) to analyze the binding mode of these compounds. Four derivatives 4a, 4b, 4c,
and 4d were selected for investigation of in vitro anticancer potential using colorectal cancer cell line HCT 116. The
anti-tumor activities of synthesized compounds were further validated by evaluating the inhibitory effects of these
compounds on the target protein beta-catenin through in vitro enzyme inhibitory assay.

Conclusion:
In conclusion, the synthesized compounds showed significant anti-tumor activities both in silico and in
vitro, having potential for further investigating its role in colorectal cancer.
Status of Indonesia's sovereign rights in the north natuna sea conflict area consequences of China's nine-dash line claim
Authors: Fernandes Inggrit , Daulay Zainul , Ferdi Ferdi , Delfiyanti Delfiyanti 
Published: December 2021

The existence of sovereign rights in the North Natuna Sea has begun to be disturbed since China's claim of traditional fishing rights was strengthened by the nine-dash line claim. This claim includes the North Natuna Sea area into China's territorial sea, which makes this area a conflict area. The problem in this research is the existence of traditional fishing ground rights in UNCLOS III 1982 and the impact of the nine-dash line claim on Indonesia's sovereign rights in the conflict area of ??the North Natuna Sea. This study uses a normative legal research method with a statutory and conceptual approach. The results of the study explained that the 1982 UNCLOS III did not regulate traditional fishing ground, and the impact of the nine-dash line claim is very significant, as can be seen from the activities of Chinese fishers in the North Natuna Sea, which are supported by Chinese coast guard vessels, which have disrupted Indonesia's enjoyment of its sovereign rights. Thus, it can be concluded that the traditional fishing ground rights with the nine-dash line claim are not based on international law but are only based on China's unilateral claims and create conflicts that impact Indonesia.
Burnout Syndrome in public school teachers in Sorocaba, São Paulo, Brazil
Authors: Souza Maíra Cazeto Lopes de , Lucca Sérgio Roberto de 
Published: December 2021

Objective: To identify the prevalence of Burnout Syndrome (BS) in a sample of 107 elementary school teachers (cycle II and high school) in Sorocaba/SP and analyze possible associations of psychosocial and organizational factors at work with the dimensions of burnout. Methods: Cross-sectional epidemiological study, conducted through a selection of a convenience sample, which included 107 teachers from state schools in Sorocaba using the following criteria: having entered the public teaching career for at least one year and working predominantly as a teacher, that is, not having more hours in administrative positions. Data collection was conducted in eight schools in the city, and two forms were used, the “Maslach Burnout Inventarie-Educators Survey” (MBI-ES) and a biopsychosocial form. Pearson's chi-square test and logistic regression analysis were performed for data analysis, adopting a significance level of 5%. Results: There was a prevalence of BS in 4.7% of teachers, with 29% of teachers showing high Emotional Exhaustion, 33.6% high Depersonalization and 18.7% low Professional Fulfillment. Positive associations were found between factors such as lack of recognition, dissatisfaction with work and situations of harassment with the dimensions of the BS. Conclusion: The results suggest a warning sign for illness characterized by burnout in the sample of teachers studied.
Study of type 1 vascular adhesion molecules in patients with acute myocardial infarction with ST segment elevation at different body weights
Authors: Zakovryashina I. N. , Khaisheva L. A. , Shlyk S. V. , Garina I. A. 
Published: December 2021

Objective: to study the level of adhesion molecules in patients with STEMI with different BMI at the hospital stage and 12 months after the index event.Materials and methods: the study included 126 people with STEMI who had undergone PCI and 27 people in the control group. The analysis of the level of svcam‑1 in peripheral blood at the beginning of the disease and after 12 months was carried out, BMI and waist volume were measured. An assessment of the nature and frequency of complications after STEMI was performed.Results: the levels of biomarkers of the vascular endothelial adhesion molecule type 1 increase during the acute period of stemi, statistically signifi tly decrease, but remain increased by 3.5 times 12 months after the index event compared with the initial values. There was no association of VCAM‑1 with visceral obesity in the groups of our patients. Vascular endothelial adhesion molecules of type 1 increase in patients with a fatal outcome, as well as with an increase in the severity of OSN and CHF. Thus, VCAM 1 can be a predictor of an unfavorable outcome of AMI.Conclusions: the article presents the study of a marker of systemic inflammation VCAM‑11 in patients with STEMI with various types of obesity or BMI at the stage of hospitalization and outpatient follow‑up during the year. The determination of the VCAM‑1 level can be used to assess the intensity of the inflammatory process and the risk of adverse outcomes.
Comparison of User-Oriented Information Services on the Websites of Large Hospitals in China and the United States: Cross-sectional Study
Authors: Zhong Yang , Tao Wenjuan , Yang Yanlin , Wu Hao , Li Weimin , Wen Jin 
Published: December 2021

Background
Many people use the internet to access health care information to support health care decisions, and hospital websites can be the first point of contact to provide health care information services for consumers. However, little is known about the current information services provided by the websites of large Chinese hospitals.

Objective
The aim of this study is to evaluate and compare the information services of the websites of large hospitals in China and the United States. We hope that our findings will benefit hospital managers worldwide in providing service information on the web.

Methods
This study adopted a cross-sectional analytical approach to evaluate the websites of large hospitals in China and the United States in 2020. A total of 300 large hospitals were randomly selected, of which half were in China and half were in the United States. Based on the 7Ps marketing mix, we identified 39 items that represent typical hospital website information services, covering the following seven dimensions: product, price, place, propagation, people, process, and physical evidence.

Results
Most of the items (34/39, 87%) related to information services offered by hospital websites were less covered in China than in the United States; however, 5 items (appointments by a third-party platform, mobile payment, hospital value, hospital environment display, and physicians’ profiles) had higher coverage in China. The average scores for hospital websites in China and the United States were 13.25 (SD 2.99) points and 23.16 (SD 2.76) points, respectively. Generally, high scores were given to the south areas of China and north areas of the United States.

Conclusions
Hospital websites in China lagged behind those in the United States with regard to information services offered. We recommend that hospital managers in China place more emphasis on the people, product, and propagation dimensions of the 7Ps marketing mix in the construction of information services on hospital websites. Through the comparison of the websites of large hospitals in China and the United States, our study findings can provide suggestions for forming standard hospital website construction guidelines worldwide.
Internet-Based Information Behavior After Pregnancy Loss: Interview Study
Authors: Andalibi Nazanin , Bowen Kristen 
Published: December 2021

Background
Information behavior describes all human behaviors in relation to information. Individuals experiencing disruption or stigma often use internet-based tools and spaces to meet their associated information needs. One such context is pregnancy loss, which, although impactful and common, has been absent from much of feminist and reproductive health and information behavior scholarship. By understanding information behavior after pregnancy loss and accounting for it in designing internet-based information spaces, we can take a meaningful step toward countering the stigma and silence that many who experience such loss endure, facilitate coping, and make space for diverse pregnancy narratives in our society.

Objective
This study’s objective is to provide a characterization of internet-based information behavior after pregnancy loss.

Methods
We examined internet-based information behavior after pregnancy loss through 9 in-depth interviews with individuals residing in the United States. We analyzed the data by using open and axial coding.

Results
We identified the following three themes in relation to participants’ information behavior in internet-based spaces: needed information types, information-related concerns, and information outcomes. We drew from information behavior frameworks to interpret the processes and concerns described by participants as they moved from recognizing information needs to searching for information and to using information and experiencing outcomes. Specifically, we aligned these themes with information use concepts from the information behavior literature—information search, knowledge construction, information production, information application, and information effects. Participants’ main concerns centered on being able to easily find information (ie, searchability), particularly on topics that had already been covered (ie, persistence), and, once found, being able to assess the information for its relevance, helpfulness, and credibility (ie, assessability). We suggest the following design implications that support health information behavior: assessability, persistence, and searchability.

Conclusions
We examined internet-based information behavior in the context of pregnancy loss, an important yet silenced reproductive health experience. Owing to the prevalence of information seeking during pregnancy, we advocate that generic pregnancy-related information spaces should address the needs related to pregnancy loss that we identified in addition to spaces dedicated to pregnancy loss. Such a shift could not only support those who use these spaces to manage pregnancies and then experience a loss but also help combat the silence and stigma associated with loss and the linear and normative narrative by which pregnancies are often represented.
Participatory Design of a Mobile App to Safeguard Mental Resilience in the Context of Drug Use in Young Adults: Multi-Method Study
Authors: Ben-Yehuda Ofri , Dreazen Efrat , Koren Danny , Peleg Mor 
Published: December 2021

Background
Existing mental health apps are largely not aimed at generally healthy young people who may be experimenting with addictive substances and mind-altering experiences.

Objective
The aim of this study is to examine the interest and expectations of young people regarding a proposed smartphone app designed to help protect and promote mental health and resilience in the face of risks associated with substance use.

Methods
The study was based on agile system development and had 3 empirical substudies. Our feasibility study (study 1) included an anonymous questionnaire that examined the potential interest of young people in this type of app. It was answered by 339 Israelis aged 18-30 years. The second part of the feasibility study was a pilot study with 1.2% (4/339) of the people who answered the questionnaire and expressed interest in participating in a focus group. They tested and refined the elements planned for the focus groups. Study 2 was a participatory design study involving 7 focus groups of 5 to 7 participants each (young people aged 18-35 years, n=38). Persona development, open discussion, and a Technology Acceptance Model questionnaire were used to elicit user expectations and requirements for the app and to understand the perceived usefulness and usability of the proposed features. Study 3 comprised in-depth interviews with experts in the field of youth mental health and drug use to enlist their professional opinion regarding the value of such an app and recommendations about the features it should include.

Results
The mock-up for the proposed app had five key features: personalized assessment of risk for a drug-associated mental crisis, support for self-monitoring, useful information (eg, warning signs and first-aid guidelines), resilience-building exercises, and a support center. Participants rated highly the usefulness of all 5 main features and 96% (24/25) of the specific features we proposed within those main categories. The participants also suggested additional features as well as a new user persona we had not considered: the parents or family members of the young person. The focus groups rated highly the perceived usability of the app. Most of the experts saw value in all the main features and suggested specific knowledge sources for the app’s content. Finally, participants of both the feasibility study and the participatory design study expressed moderate to high interest in using the app for self-help and high interest in using the app to help friends.

Conclusions
The findings provide preliminary encouraging support for the 5 main features suggested by the research team and reinforce recommendations for mobile health apps found in the literature. The findings emphasize the insight that this kind of app should be designed primarily for use by individuals seeking to help others.
Privacy Management in Social Network Sites: A Case Study on the Use of Finstagram for Mediated Voyeurism
Authors: Nurbaiti Alya , Anshari Irham Nur 
Published: December 2021

In 2015, Instagram users started to create secondary accounts dubbed finstagram (fake Instagram) to fulfill the unmet needs of using the main account. Among the needs is to do mediated voyeurism or stalking — the act of watching other’s lives through the means of the media — safely. Prior Instagram studies have been more focused on the self-disclosure discourse while analysis on the voyeurs as consumers of disclosure is lacking. Using the case study method, this paper records the exercise of mediated voyeurism through finstagram and the privacy management that occurs within. The result shows that the use of finstagram for mediated voyeurism is driven by the perceived privacy risk (perceived risk of possible privacy violations). The perceived privacy risk encourages voyeur to navigate privacy management by adopting protecting behavior, or various forms of action taken to protect the exercise of stalking.
LEGAL PROTECTION OF THE PARTIES IN CREDIT AGREEMENT WITH FIDUCIARY GUARANTEE AFTER THE ISSUENCE OF CONSTITUTIONAL COURT DECISION No. 18/PUU-XVII/2019
Authors: Kristiyanti Celina Tri Siwi 
Published: December 2021

Fiduciary Guarantee Law is one of the material guarantees specifically regulated in Law No. 42 of 1999 on Fiduciary Guarantees that realizes the public's need for legal certainty but guaranteed objects still have economic value. Article 15 of Law No. 42 of 1999 concerning Fiduciary Guarantees is felt burdensome to debtors, because creditors make forced efforts to take fiduciary guarantee objects in the form of 2-wheeled and 4-wheeled vehicles. The purpose of this study is (1) Finding and analyzing the basis of the Constitutional Court's Decision No. 18/PUU-XVII/2019 (2) Finding and explaining the legal consequences of the Constitutional Court Decision No. 18/PUU-XVII/2019 on legal protection for parties to credit agreements with fiduciary guarantees (3) Finding and explaining constraints on Financial Service Institutions (LJK) in the implementation of constitutional court decision No. 18/PUU-XVII/2019. The research method used is juridical normative and empirical with a case study approach so that achievements are more comprehensive related to the principle of legal protection for parties in fiduciary guarantees. The result obtained that since the Decision of the Constitutional Court No. 18/PUU-XVII/2019, the executive confiscation cannot be done directly by creditors must go through a court decision. The executorial confiscation in Article 15 of Law Number 42 concerning Fiduciary Guarantee has been contrary to Article 1 (3), Article 27 (1), Article 28D (1), Article 28G (1) and Article 28H (4) of the Constitution of 1945. It takes good faith from the parties so that the implementation of the Constitutional Court Decision No. 18/PUU-XVII/2019 guarantees justice, legal certainty and provides legal protection. An agreement is required in accordance with the principle of freedom of proportionate contract, there is a balance of position between the debtor and the creditor.
Capsaicin 8% Patch for Alternative Therapy of Painful Diabetic Peripheral Neuropathy
Authors: Adnan Muhammad Luthfi 
Published: December 2021

Abstract
Diabetes is one of the most common health problems due to its high incidence and complications. One of the complications associated with diabetes is painful diabetic peripheral neuropathy (PDPN). The capsaicin 8% patch is a localized pain treatment that provides effective pain relief from a single application in patients with peripheral neuropathic pain. The aim of this review is to discuss the effect of capsaicin patch 8% in patients with painful diabetic peripheral neuropathy. The search strategy was conducted in PubMed and modified for other databases. The search was limited to English-language reports. The keywords used were "capsaicin”, "capsaicin patch", "painful diabetic peripheral neuropathy", and "pain management". The inclusion criteria used were randomized controlled trials (RCTs), clinical trials or another interventional analysis with full text in English with publications less than the last 10 years. The exclusion criteria used were a review, systematic review, or meta-analysis, studies that were not conducted in humans and non-full text in English with publications over the last 10 years. Results: There are 2 full-text that meet inclusion criteria. From articles related to studies that have been conducted, the use of capsaicin 8% patch can reduce pain, improve nerve function and quality of life in PDPN patients. The use of capsaicin 8% patch has the advantage to pain relief for patients with painful diabetic peripheral neuropathy.
Keywords: Alternative therapy, Capsaicin 8% Patch, Diabetes complications, Pain Relief, Painful Diabetic Peripheral Neuropathy, topical drugs
Оболочечные структуры: генезис, материалы и подвиды. Часть 2. Конструкционные строительные материалы *)
Authors: Кривошапко Сергей , Алборова Лана , Мамиева Ираида 
Published: December 2021

В статье рассматриваются стилевые течения применительно к тонким оболочкам и оболочечным структурам. Причём, вышесказанное не касается технологических оболочек и пространственных структур, таких как трубопроводы, подземные туннели, машиностроительные изделия и т.д. Все рассмотренные стили проиллюстрированы конкретными построенными объектами. Установлено, что всего при проектировании оболочечных структур архитекторами было использовано 26 архитектурных стилей и стилевых направлений. Для интересующихся более подробной информацией приводится обширная библиография.
*) «Часть 1. Подвиды и направления» статьи «Оболочечные структуры: генезис, материалы и подвиды» опубликована в № 3 журнала «Academia. Архитектура и строительство» за этот год.