bluuebunny/crossref_metadata_2025_split huggingface dataset:
Could widespread use of antiviral treatment curb the COVID-19 pandemic? A modeling study
Authors: Matrajt Laura , Brown Elizabeth R. , Cohen Myron S. , Dimitrov Dobromir , Janes Holly 
Published: November 2021

AbstractDespite the development of safe and effective vaccines, effective treatments for COVID-19 disease are still urgently needed. Several antiviral drugs have shown to be effective in reducing progression of COVID-19 disease. In the present work, we use an agent-based mathematical model to assess the potential population impact of the use of antiviral treatments in four countries with different demographic structure and current levels of vaccination coverage: Kenya, Mexico, United States (US) and Belgium. We analyzed antiviral effects on reducing hospitalization and death, and potential antiviral effects on reducing transmission. For each country, we varied daily treatment initiation rate (DTIR) and antiviral effect in reducing transmission (AVT). Irrespective of location and AVT, widespread antiviral treatment of symptomatic adult infections (≥20% DTIR) prevented the majority of COVID-19 deaths, and recruiting 6% of all adult symptomatic infections daily reduced mortality by a third in all countries. Furthermore, our model projected that targeting antiviral treatment to the oldest age group (65 years old and older, DTIR of 20%) can prevent over 47% of deaths. Our results suggest that early antiviral treatment (as soon as possible after inception of infection) is needed to mitigate transmission, preventing 50% more infections compared to late treatment (started 3 to 5 days after symptoms onset). Our results highlight the synergistic effect of vaccination and antiviral treatment: as the vaccination rate increases, antivirals have a larger relative impact on population transmission. These results suggest that antiviral treatments can become a strategic tool that, in combination with vaccination, can significantly reduce COVID-19 hospitalizations and deaths and can help control SARS-CoV-2 transmission.
Nanopore 16S rRNA sequencing reveals alterations in nasopharyngeal microbiome and enrichment ofMycobacteriumandMycoplasmain patients with COVID 19
Authors: Mahapatra Soumendu , Mishra Rasmita , Prasad Punit , Murmu Krushna Chandra , Aggarwal Shifu , Sethi Manisha , Mohapatra Priyanka , Ghosh Arup , Yadav Rina , Dodia Hiren , Ansari Shamima Azma , De Saikat , Singh Deepak , Suryawanshi Amol , Dash Rupesh , Senapati Shantibhushan , Beuria Tushar K. , Chattopadhyay Soma , Syed Gulam Hussain , Swain Rajeeb , Raghav Sunil K. , Parida Ajay 
Published: November 2021

AbstractThe coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a major global health concern. This virus infects the upper respiratory tract and causes pneumonia-like symptoms. So far, few studies have shown that respiratory infections alter nasopharyngeal (NP) microbiome diversity and enrich opportunistic pathogens. In this study, we have sequenced the 16S rRNA variable regions, V1 through V9, extracted from NP samples of control and COVID-19 (symptomatic and asymptomatic) participants using the Oxford Nanopore™ technology. Comprehensive bioinformatics analysis investigating the alpha/beta diversities, non-metric multidimensional scaling, correlation studies, canonical correspondence analysis, linear discriminate analysis, and dysbiosis index analysis revealed control and COVID-19-specific NP microbiomes. We observed significant dysbiosis in COVID-19 NP microbiome with abundance of opportunistic pathogens such asCutibacterium, Corynebacterium, Oerskovia, andCellulomonasin asymptomatic patients, and ofStreptomycesandMycobacteriaceaefamily in symptomatic patients. Furthermore, we observed sharp rise in enrichment of opportunistic pathogens in symptomatic patients, with abundance ofMycobacteriaandMycoplasma, which strongly correlated with the occurrences of chest pain and fever. Our findings contribute novel insights regarding emergence of opportunistic pathogens in COVID-19 patients and their relationship with symptoms, suggesting their potential role in coinfections.
Understanding national trends in COVID-19 vaccine hesitancy in Canada – April 2020 to March 2021
Authors: Lavoie Kim L. , Gosselin-Boucher Vincent , Stojanovic Jovana , Gupta Samir , Gagne Myriam , Joyal-Desmarais Keven , Seguin Katherine , Sheinfield-Gorin Sherri , Ribeiro Paula , Voisard Brigitte , Vallis Michael , Corace Kim , Presseau Justin , Bacon Simon L. ,   for the iCARE Study Team
Published: November 2021

AbstractObjectiveKey to reducing COVID-19 morbidity and mortality and reducing the need for further lockdown measures in Canada and worldwide is widespread acceptance of COVID-19 vaccines. Vaccine hesitancy has emerged as a key barrier to achieving optimal vaccination rates, for which there is little data among Canadians. This study examined rates of vaccine hesitancy and their correlates among Canadian adults.MethodsThis study analyzed data from five age, sex and province-weighted population-based samples to describe rates of hesitancy between April 2020 and March 2021 among Canadians who completed online surveys as part of the iCARE Study, and various sociodemographic, clinical and psychological correlates. Vaccine hesitancy was assessed by asking: “If a vaccine for COVID-19 were available today, what is the likelihood that you would get vaccinated?” Responses were dichotomized into ‘very likely’, ‘unlikely’, ‘somewhat unlikely’ (reflecting some degree of vaccine hesitancy) vs ‘extremely likely’ to get the vaccine, which was the comparator.ResultsOverall, 15,019 respondents participated in the study. A total of 42.2% of respondents reported vaccine hesitancy over the course of the study, which was lowest during surveys 1 (April 2020) and 5 (March 2021) and highest during survey 3 (November 2020). Fully adjusted multivariate logistic regression analyses revealed that women, those aged 50 and younger, non-Whites, those with high school education or less, and those with annual household incomes below the poverty line in Canada (i.e., $60,000) were significantly more likely to report being vaccine hesitant over the study period, as were essential and healthcare workers, parents of children under the age of 18, and those who do not get regular flu vaccines. Believing engaging in infection prevention behaviours (like vaccination) is important for reducing virus transmission and high COVID-19 health concerns (being infected and infecting others) were associated with 77% and 54% reduction in vaccine hesitancy, respectively, and having high personal financial concerns (worried about job or income loss) was associated with 1.33 times increased odds of vaccine hesitancy.ConclusionResults point to the importance of targeting vaccine efforts to women, younger people and socioeconomically disadvantaged groups, and that vaccine messaging should emphasize the benefits of getting vaccinated, and how the benefits (particularly to health) far outweigh the risks. Future research is needed to monitor ongoing changes in vaccine intentions and behaviour, as well as to better understand motivators and facilitators of vaccine acceptance, particularly among vulnerable groups.
Evaluation of Pre-operational Factors Contributing to a Dorsal Column Stimulator Explantation
Authors: Kinne Maximilian A. , Cowan R. Scott , Knee Alexander 
Published: November 2021

ObjectivesImplantation of a dorsal column stimulator (DCS) for axial spine and radicular pain is a commonly performed procedure. Despite the benefits of this device to reduce pain and improve quality of life, some patients elect to have the device explanted. The purpose of this study is to describe pre-operational factors among patients who elected to have their DCS explanted and how these factors are associated with reason for explantation.Materials and MethodsWe conducted a retrospective descriptive study using the database of a private outpatient orthopedic clinic. We included all patients who had a DCS explanted between January 1, 2007 and June 19, 2014. Data was collected on patient demographics, past medical and back surgery history, as well as details of implantation, permanent device implantation, and subsequent explantation. Reasons for explantation were categorized as: inadequate pain control using three categories (with no device-related pain/discomfort, with device-related pain/discomfort, or inadequate pain control and patient wants MRI), or pain resolved.ResultsA consecutive sample of 100 subjects who underwent explantation of a DCS was identified for review. Of these 100 subjects, 14 were excluded. Based on our data, we hypothesize that sex (57% female, 43% male) degenerative disc disease (72%), previous back surgery (70%), BMI classified as overweight (subject average = 28.3), history of tobacco usage (57%), and history of narcotic use (80%) may be potential risk factors for explantation.ConclusionsWith respect to clinical evaluation of patients as candidates for spinal cord stimulator implantation, we cannot recommend that any of the evaluated variables be considered a contraindication to proceeding with a trial procedure. Future studies are planned to compare these data to a control group of subjects to establish risk factors predisposing individuals to explantation of a DCS.
Transcriptome innovations in primates revealed by single-molecule long-read sequencing
Authors: Ferrández-Peral Luis , Zhan Xiaoyu , Álvarez-Estapé Marina , Chiva Cristina , Esteller-Cucala Paula , García-Pérez Raquel , Julià Eva , Lizano Esther , Fornas Òscar , Sabidó Eduard , Li Qiye , Marquès-Bonet Tomàs , Juan David , Zhang Guojie 
Published: November 2021

AbstractTranscriptomic diversity greatly contributes to the fundamentals of disease, lineage-specific biology, and environmental adaptation. However, much of the actual isoform repertoire contributing to shaping primate evolution remains unknown. Here, we combined deep long- and short-read sequencing complemented with mass spectrometry proteomics in a panel of lymphoblastoid cell lines (LCLs) from human, three other great apes, and rhesus macaque, producing the largest full-length isoform catalog in primates to date. Our transcriptomes reveal thousands of novel transcripts, some of them under active translation, expanding and completing the repertoire of primate gene models. Our comparative analyses unveil hundreds of transcriptomic innovations and isoform usage changes related to immune function and immunological disorders. The confluence of these innovations with signals of positive selection and their limited impact in the proteome points to changes in alternative splicing in genes involved in immune response as an important target of recent regulatory divergence in primates.
The genetic diversity of Ethiopian barley genotypes in relation to their geographical origin
Authors: Teklemariam Surafel Shibru , Bayissa Kefyalew Negisho , Matros Andrea , Pillen Klaus , Ordon Frank , Wehner Gwendolin 
Published: November 2021

AbstractEthiopia is recognized as a center of diversity for barley, and its landraces are known for the distinct genetic features compared to other barley collections. The genetic diversity of Ethiopian barley likely results from the highly diverse topography, altitude, climate conditions, soil types, and farming systems. To get detailed information on the genetic diversity a panel of 260 accessions, comprising 239 landraces and 21 barley breeding lines, obtained from the Ethiopian biodiversity institute (EBI) and the national barley improvement program, respectively were studied for their genetic diversity using the 50k iSelect single nucleotide polymorphism (SNP) array. A total of 983 highly informative SNP markers were used for structure and diversity analysis. Three genetically distinct clusters were obtained from the structure analysis comprising 80, 71, and 109 accessions, respectively. Analysis of molecular variance (AMOVA) revealed the presence of higher genetic variation (89%) within the clusters than between the clusters (11%), with moderate genetic differentiation (PhiPT=0.11) and adequate gene flow (Nm=2.02). The Mantel test revealed that the genetic distance between accessions is poorly associated with their geographical distance. Despite the observed weak correlation between geographic distance and genetic differentiation, for some regions like Gonder, Jimma, Gamo-Gofa, Shewa, and Welo, more than 50% of the landraces derived from these regions are assigned to one of the three clusters.
Early Development of Mushroom Bodies in the Brain of the Honeybee Apis mellifera as Revealed by BrdU Incorporation and Ablation Experiments
Authors: Malun Dagmar 
Published: November 2021

In the honeybee the mushroom bodies are prominent neuropil structures arranged as pairs in the dorsal protocerebrum of the brain. Each mushroom body is composed of a medial and a lateral subunit. To understand their development, the proliferation pattern of mushroom body intrinsic cells, the Kenyon cells, were examined during larval and pupal stages using the bromodeoxyuridine (BrdU) technique and chemical ablation with hydroxyurea.By larval stage 1, ∼40 neuroblasts are located in the periphery of the protocerebrum. Many of these stem cells divide asymmetrically to produce a chain of ganglion mother cells. Kenyon cell precursors underly a different proliferation pattern. With the beginning of larval stage 3, they are arranged in two large distinct cell clusters in each side of the brain. BrdU incorporation into newly synthesized DNA and its immunohistochemical detection show high mitotic activity in these cell clusters that lasts until mid-pupal stages. The uniform diameter of cells, the homogeneous distribution of BrdU-labeled nuclei, and the presence of equally dividing cells in these clusters indicate symmetrical cell divisions of Kenyon cell precursors.Hydroxyurea applied to stage 1 larvae caused the selective ablation of mushroom bodies. Within these animals a variety of defects were observed. In the majority of brains exhibiting mushroom body defects, either one mushroom body subunit on one or on both sides, or three or four subunits (e.g., complete mushroom body ablation) were missing. In contrast, partial ablation of mushroom body subunits resulting in small Kenyon cell clusters and peduncles was observed very rarely. These findings indicate that hydroxyurea applied during larval stage 1 selectively deletes Kenyon stem cells. The results also show that each mushroom body subunit originates from a very small number of stem cells and develops independently of its neighboring subunit.
The blind accountant in Blindness by José Saramago and accountant stereotypes
Authors: Carnegie Garry D. 
Published: November 2021

PurposeThis paper aims to encourage the extension of the literature on accountant stereotypes beyond primarily Angelo-American contexts based on reflections formed on reading the novel, Blindness, by José Saramago.Design/methodology/approachA mindful insight into how an accountant, blind since birth, is portrayed in the novel Blindness by acclaimed Portuguese author Saramago, a Nobel Prize for Literature recipient.FindingsThe study reveals characters under extreme circumstances when a city is plunged into a blindness epidemic, or distinctive “white blindness”, and failings in human behaviour, particularly by hoodlums and their leaders, including the blind accountant.Research implicationsBy reflecting on what we take for granted in the accountant stereotypes literature, this paper illuminates how we can all contribute new understandings of accounting and accountants more specifically in all contexts in which the discipline and its practitioners operate, including non-Anglo-American contexts.Originality/valueThe paper presents the insights of a member of the historical and interdisciplinary accounting research community with experience in research and publication on accountant stereotypes.
Components to foster organizational resilience in tourism SMEs
Authors: Núñez-Ríos Juan E. , Sánchez-García Jacqueline Y. , Soto-Pérez Manuel , Olivares-Benitez Elias , Rojas Omar G. 
Published: November 2021

PurposeSmall- and medium-sized enterprises (SMEs) mainly rely on their structure and internal networks to achieve their goals and remain competitive. However, their limited internal capabilities and complex environments can hinder their stability. Thus, this study evaluated the relationships among specific factors toward fostering organizational resilience (OR) in tourism SMEs.Design/methodology/approachA multi-methodological approach was adopted to address this research study, including (1) social network analysis (SNA) to formulate the conceptual model and (2) construct validation through partial least squares path modeling (PLS-PM).FindingsThe six proposed hypotheses were supported. These results suggest that addressing these variables and relationships after considering management style and people development as critical factors can foster OR in tourism SMEs.Research limitations/implicationsThe ideas that were developed were constrained to the organizational domain. Although the results apply to the Mexican context, this limitation can be offset by extending the proposal to other emergent regions or organizations. This can also increase the generalization of the results and foster improvements in the approaches applied.Practical implicationsAcademics and managers must rethink resilience as the final state generated by multiple factors. This requires reconfiguring inner organizational interactions, providing more autonomy to operative units, reinforcing business intelligence and improving feedback mechanisms.Originality/valueThis research study contrasts previous studies because it proposes that SNA be exploited to avail of the advantages it confers in designing the conceptual model. In this regard, we present new relationships to promote OR and provide new avenues in order to improve the analysis of adaptation processes.
Influence of job insecurity on coal miners’ safety performance: the role of emotional exhaustion
Authors: Yi Tao , Dong Yao , Li Jizu 
Published: November 2021

Purpose
Under the de-capacity circumstances of coal production in China, the purpose of this paper is to examine the processes underlying the association between job insecurity (JI) and miners’ safety performance, proposing that resource consumption is a prominent theoretical explanation for this association. By developing a mediation model, the authors examined the mediating role of emotional exhaustion (EE) between JI and miners’ safety performance.

Design/methodology/approach
Through the time-lagged survey method, the authors collected 349 samples from three coal mines in Shanxi Lu’an Group, the hypotheses were tested through confirmatory factor analysis, structural equation model analysis and bootstrapping in AMOS software.

Findings
Results shed light on that JI negatively predicts the safety performance subfactors, including safety compliance (SC) and safety participation (SP). EE plays a partial mediating role between JI and safety performance. In particular, the finding indicated that JI exerts a more significant impact on SP than SC, revealing that JI produces a more significant adverse effect on miners’ conscious safety behaviors than skill-based safety behaviors.

Originality/value
This study contributes to display the influence path of JI as a stressor on miners’ safety performance in the coal mine rather than a stimulus. The mediation model results not only help us understand the association between JI and safety performance but also provide a feasible way to mitigate the negative effects of JI.
A piecewise analytical model of bearingless switched reluctance motor for full rotor angular positions
Authors: Wang Yi , Wang Honghua , Zhang Jingwei , Tan Chao 
Published: November 2021

Purpose
This paper aims to establish a piecewise Maxwell stress analytical model of bearingless switched reluctance motor (BSRM) for the full rotor angular positions. The proposed model varies from the existing models, which are only applicable to the partial-overlapping positions of stator and rotor poles. By extending the applicable rotor angular positions, this model provides a basic analytical model for the multi-phase excitation control of BSRM.

Design/methodology/approach
The full rotor angular positions are classified into the partial-overlapping positions and the non-overlapping positions. At first, two different air gap subdividing methods are proposed, respectively, for the two-position ranges. Then, different integration paths are selected accordingly. Furthermore, two approximate methods are presented to calculate the average flux density of each air gap subdivision. Finally, considering the mutual coupling between the two perpendicular radial suspension forces, a piecewise Maxwell stress analytical model is derived for the full rotor angular positions of BSRM.

Findings
A piecewise Maxwell stress analytical model of BSRM is built for the full rotor angular positions, and applicable to the multi-phase excitation mode of BSRM. For the partial-overlapping positions and the non-overlapping positions, two sets of air gap subdividing methods, integration paths and approximate calculation methods of air gap flux densities are proposed, respectively. The accuracy and reliability of the proposed model are verified by the finite element method.

Originality/value
The piecewise Maxwell stress analytical model of BSRM for the full rotor angular positions is proposed for the first time. The novel air gap subdividing methods, integration paths, approximate calculation methods of air gap flux densities and the coupling between the two radial suspension forces are adopted to improve the modeling accuracy. As the applicable range of rotor angular position is extended, this model overcomes the limitation of the existing models only for single-phase excitation mode and contributes to the accurate control of BSRM multi-phase excitation mode.
Keeping key suppliers alive during the COVID-19 pandemic: artificial supply chain resilience and supplier crisis response strategies
Authors: Fracarolli Nunes Mauro , Lee Park Camila , Paiva Ely 
Published: November 2021

PurposeThe study investigates supply chain leaders’ initiatives to support their partners in the early stages of the coronavirus disease-2019 (COVID-19) pandemic, identifying measures taken to increase supply chain resilience and their impact on the quality of supply chain relationships.Design/methodology/approachTwo complementary phases are employed. First, an exploratory approach is adopted, with the method of discourse analysis being employed in the identification of the supplier crisis response strategies by S&P500’s top 30 firms. Second, two scenario-based experiments with 983 participants evaluated the impact of such strategies in two dimensions of supply chain relationships’ quality (supplier satisfaction and supplier commitment).FindingsPhase one revealed five initiatives’ groups adopted: safety measures, innovative tools, information and knowledge sharing, supply chain finance and supply chain continuity. Phase two results indicate that supplier crisis response strategies have positive effects on both supplier satisfaction and commitment. Data also suggest that safety measures, innovative tools, and information and knowledge sharing strategies negatively impacted supplier satisfaction and commitment, when compared with strategies adopted by other buying firms competing for the same supplier. Supply chain continuity was negatively associated with both dimensions when other buying firms implemented innovative tools and information and knowledge sharing strategies with their suppliers, while supply chain finance yielded in no differences in comparison to strategies adopted by competing buying firms.Originality/valueThe authors offer a theoretical typology for supply chain resilience (i.e. natural and artificial), providing support for buying firms’ decisions regarding supplier crisis response strategies through the strengthening of artificial supply chain resilience to increase the likelihood of vulnerable key suppliers’ survival.