bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mass spectrometer‐based pore‐water sampling system for sandy sediments
Authors: Chua Emily J. , Short Robert Timothy , Cardenas‐Valencia Andres M. , Savidge William , Fulweiler Robinson W. 
Published: October 2021

AbstractHighly permeable sandy sediments dominate the productive continental shelves and likely play a key role in global biogeochemical cycles. Despite their prominence, we currently have a poor understanding of how sandy sediments function and how they will respond to climate change. This knowledge gap is largely due to the difficulty in accurately sampling sandy sediments, as no method yet exists for measuring a range of analytes while accounting for advective pore‐water flow in these dynamic environments. To help address this, we developed a new pore‐water sampler that, when coupled to a portable mass spectrometer, can measure a suite of dissolved gases (e.g., O2, N2, Ar, CO2, and CH4) in sandy sediments. Here, we present a series of laboratory experiments to validate and calibrate the instrument, as well as proof‐of‐concept submersion and field tests. Our results show that with some design improvements, our system will be capable of sustained (hourly to diel) in situ measurements in sandy sediments. This new approach has the potential to provide a large volume of high‐quality data in any aquatic system with sandy sediments and thus greatly advance our understanding of biogeochemical processes occurring in these environments.
Traffic light signals and healthy food choice: Investigating gender differences
Authors: Meng Yan , Chan Eugene Y. 
Published: October 2021

AbstractNutrition labels conveying nutrition information using traffic light signals are becoming common, but traffic light signals' effectiveness to help consumers make healthy food decisions is still debated. In the current research, we propose gender differences in the usage of traffic light signals. In Study 1, we presented male and female participants with a nutrition label that we manipulated as either unhealthy or healthy by changing the nutrient amounts, and the nutrition label either had a green or red color frame surrounding it. Although both men and women responded equally to information conveyed in text form, men were more likely to rely on the color to help them assess the target food product's healthiness. We replicated this result in Study 2: Holistic thinking mediated the men's reliance on color labeling schemes when deciding to buy a targeted food product. These results suggest there are differences in the consumer groups (segmented by gender) for whom traffic light signals on food packaging would be beneficial in playing a role in healthy food decision‐making. For policymakers, our findings indicate that target consumers need to be considered in nutrition labeling generally.
“My place is your place” ‐ Understanding how psychological ownership influences peer‐to‐peer service experiences
Authors: Pino Giovanni , Nieto‐García Marta , Zhang Carol X. 
Published: October 2021

AbstractThis study aims to contribute to the growing literature on peer‐to‐peer services by investigating the relationships among three relevant aspects of such services, namely customers' identification with service providers, customers' feelings of psychological ownership toward the service setting (i.e., the providers' resources), and customers' interaction with service providers. Two empirical studies that investigate real peer‐to‐peer hospitality service experiences demonstrate that identification with service providers engenders a sense of psychological ownership of the service setting, which, in turn, enhances customers' attitudinal and behavioral loyalty. Notably, this effect occurs only when customers engage in cooperative interactions with their service providers.
Controlling Graphene Wrinkles through the Phase Transition of a Polymer with a Low Critical Solution Temperature
Authors: Kwon Minho , Yang Jiyeon , Kim Hanyoung , Joo Hyeyoung , Joo Sang‐Woo , Lee Young Sil , Lee Hye Jung , Jeong Seung Yol , Han Jong Hun , Paik Hyun‐jong 
Published: October 2021

AbstractA novel method for controlling reduced graphene oxide (rGO) wrinkles through a phase transition in a solution using a low critical solution temperature (LCST) polymer dispersant has been developed. The polymer dispersant is designed by control of architecture and composition using reversible addition‐fragmentation chain transfer polymerization. Synthesized poly(2‐(dimethylaminoethyl) methacrylate‐block‐styrene) (PDbS) can be successfully functionalized on the rGO surface via noncovalent functionalization. PDbS‐functionalized rGO (PDbS–rGO) exhibits good dispersibility in an aqueous phase at room temperature and forms wrinkles on the PDbS–rGO surface because of phase transition at the LCST of the polymer dispersant. The formation of PDbS–rGO wrinkles is controlled by varying the aggregation number of the polymer dispersant on the PDbS–rGO surface that strongly depends on temperature. This is confirmed by transmission electron microscopy, scanning electron microscopy, and Raman spectroscopy (ID’/IG ratios are 0.560, 0.579, and 0.684, which correspond to 45, 70, and 95 °C, respectively). In addition, the mechanism of wrinkle control is proved by gold nanoparticles that are grown in polymer dispersant on the PDbS–rGO surface.
Restriction of Dietary Advanced Glycation End Products Induces a Differential Plasma Metabolome and Lipidome Profile
Authors: Berdún Rebeca , Jové Mariona , Sol Joaquim , Cai Weijing , He John C. , Rodriguez‐Mortera Reyna , Martin‐Garí Meritxell , Pamplona Reinald , Uribarri Jaime , Portero‐Otin Manuel 
Published: October 2021

ScopeDiets with low content in advanced glycation end products (AGEs) lead to beneficial properties in highly prevalent age‐related diseases. To shed light on the mechanisms behind, the changes induced by a low AGE dietary intervention in the circulating metabolome are analyzed.Methods and ResultsTo this end, 20 non‐diabetic patients undergoing peritoneal dialysis are randomized to continue their usual diet or to one with a low content of AGEs for 1 month. Then, plasmatic metabolome and lipidomes are analyzed by liquid‐chromatography coupled to mass spectrometry. The levels of defined AGE structures are also quantified by ELISA and by mass‐spectrometry. The results show that the low AGE diet impinged significant changes in circulating metabolomes (166 molecules) and lipidomes (91 lipids). Metabolic targets of low‐AGE intake include sphingolipid, ether‐lipids, and glycerophospholipid metabolism. Further, it reproduces some of the plasma characteristics of healthy aging.ConclusionThe finding of common pathways induced by low‐AGE diets with previous metabolic traits implicated in aging, insulin resistance, and obesity suggest the usefulness of the chosen approach and supports the potential extension of this study to other populations.
Effectiveness of progressive muscle relaxation and laughter therapy on mental health and treatment outcomes in women undergoing in vitro fertilization: A randomized controlled trial
Authors: Kiyak Sibel , Kocoglu‐Tanyer Deniz 
Published: October 2021

AbstractA majority of infertile women experience emotional problems, such as anxiety and depression. Nurses need nonpharmacological methods rather than drugs to address women's emotional distress during the in vitro fertilization (IVF) process. The purpose of this study was to examine the effect of progressive muscle relaxation exercises and laughter therapy on the mental health and treatment outcomes of women receiving IVF treatment. This parallel‐group, randomized controlled trial was conducted in a private IVF center. Participants were randomly assigned to the intervention group (IG;n = 71) and control group (CG;n = 70). The IG received progressive muscle relaxation and laughter therapy for 40 min in each session for 3–4 sessions, whereas the CG received routine care. Data were obtained from the patient information form, State‐Trait Anxiety Inventory, Beck Depression Inventory, and medical records. The questionnaire was completed at recruitment (T1) and oocyte pick‐up day (T2). In the evaluation performed on the day of the oocyte pick‐up, depression and trait anxiety scores of the IG were found to be lower than those in the CG, and the effect size was small. Group × time interaction was significant for depression (large effect size) and trait anxiety (small effect size). The estradiol levels, the number of oocytes, transfer status, and pregnancy rates (according to a blood test) were similar between groups. Women receiving IVF treatment who received progressive muscle relaxation and laughter therapy demonstrated psychological changes; however, the treatment did not affect medical outcomes.
Homozygous WASHC4 variant in two sisters causes a syndromic phenotype defined by dysmorphisms, intellectual disability, profound developmental disorder, and skeletal muscle involvement
Authors: Gangfuß Andrea , Czech Artur , Hentschel Andreas , Münchberg Ute , Horvath Rita , Töpf Ana , O'Heir Emily , Lochmüller Hanns , Stehling Florian , Kiewert Cordula , Sickmann Albert , Kuechler Alma , Kaiser Frank J. , Kölbel Heike , Christiansen Jon , Schara‐Schmidt Ulrike , Roos Andreas 
Published: October 2021

AbstractRecessive variants in WASHC4 are linked to intellectual disability complicated by poor language skills, short stature, and dysmorphic features. The protein encoded by WASHC4 is part of the Wiskott–Aldrich syndrome protein and SCAR homolog family, co‐localizes with actin in cells, and promotes Arp2/3‐dependent actin polymerization in vitro. Functional studies in a zebrafish model suggested that WASHC4 knockdown may also affect skeletal muscles by perturbing protein clearance. However, skeletal muscle involvement has not been reported so far in patients, and precise biochemical studies allowing a deeper understanding of the molecular etiology of the disease are still lacking. Here, we report two siblings with a homozygous WASHC4 variant expanding the clinical spectrum of the disease and provide a phenotypical comparison with cases reported in the literature. Proteomic profiling of fibroblasts of the WASHC4‐deficient patient revealed dysregulation of proteins relevant for the maintenance of the neuromuscular axis. Immunostaining on a muscle biopsy derived from the same patient confirmed dysregulation of proteins relevant for proper muscle function, thus highlighting an affliction of muscle cells upon loss of functional WASHC4. The results of histological and coherent anti‐Stokes Raman scattering microscopic studies support the concept of a functional role of the WASHC4 protein in humans by altering protein processing and clearance. The proteomic analysis confirmed key molecular players in vitro and highlighted, for the first time, the involvement of skeletal muscle in patients. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.
Efficient improvement of W05‐based dyes by inserting auxiliary electron acceptors for dye‐sensitized solar cells: A theoretical investigation
Authors: Zhao Cai‐bin , Li Lin , Jin Ling‐xia , Ge Hong‐guang , Ma Jian‐qi , Wang Wen‐liang 
Published: October 2021

AbstractTo develop efficient sensitizers, five novel metal‐free dyes were designed based on one of the best dyes W05 by inserting auxiliary electron acceptors. The photovoltaic performance of new dyes was studied by density functional theory (DFT) and time‐dependent DFT (TDDFT) calculations in order to shed light on how the auxiliary electron acceptor influences on the photovoltaic performances. Results illustrated that the insertion of auxiliary electron acceptors can narrow the HOMO‐LUMO gap, red‐shift the light absorption band, and enhance the sunlight harvesting. By estimating three important photovoltaic parameters, the photoelectric conversion efficiency (PCE) of W05 was estimated to be about 8.96%, in good agreement with its experimental value of 9.22%, indicating that the scheme calculated the photovoltaic parameters is reliable. Interestingly, the estimated PCE values for designed dyes are superior to that of W05, suggesting that the molecular design is reasonable. Especially 5, its PCE was predicted to be as high as 14.07%, indicating that 5 is a promising sensitizer candidate for DSSC applications.
Applying and improving AlphaFold at CASP14
Authors: Jumper John , Evans Richard , Pritzel Alexander , Green Tim , Figurnov Michael , Ronneberger Olaf , Tunyasuvunakool Kathryn , Bates Russ , Žídek Augustin , Potapenko Anna , Bridgland Alex , Meyer Clemens , Kohl Simon A. A. , Ballard Andrew J. , Cowie Andrew , Romera‐Paredes Bernardino , Nikolov Stanislav , Jain Rishub , Adler Jonas , Back Trevor , Petersen Stig , Reiman David , Clancy Ellen , Zielinski Michal , Steinegger Martin , Pacholska Michalina , Berghammer Tamas , Silver David , Vinyals Oriol , Senior Andrew W. , Kavukcuoglu Koray , Kohli Pushmeet , Hassabis Demis 
Published: October 2021

AbstractWe describe the operation and improvement of AlphaFold, the system that was entered by the team AlphaFold2 to the “human” category in the 14th Critical Assessment of Protein Structure Prediction (CASP14). The AlphaFold system entered in CASP14 is entirely different to the one entered in CASP13. It used a novel end‐to‐end deep neural network trained to produce protein structures from amino acid sequence, multiple sequence alignments, and homologous proteins. In the assessors' ranking by summed z scores (>2.0), AlphaFold scored 244.0 compared to 90.8 by the next best group. The predictions made by AlphaFold had a median domain GDT_TS of 92.4; this is the first time that this level of average accuracy has been achieved during CASP, especially on the more difficult Free Modeling targets, and represents a significant improvement in the state of the art in protein structure prediction. We reported how AlphaFold was run as a human team during CASP14 and improved such that it now achieves an equivalent level of performance without intervention, opening the door to highly accurate large‐scale structure prediction.
Open source software reliability model with nonlinear fault detection and fault introduction
Authors: Wang Jinyong 
Published: October 2021

AbstractIn recent years, open source software (OSS) has been widely used and developed. The reliability of OSS has also become a hot research topic. Due to the complexity, dynamics, and uncertainty of the development and testing process of OSS, it is also a difficult task to accurately evaluate the reliability of OSS. In this paper, we consider the nonlinear changes of fault detection and fault introduction in the development and testing of OSS and propose a reliability model of OSS based on the nonlinear changes of fault detection and fault introduction. Experimental results show that the proposed model is more in line with the actual changes of fault detection and fault introduction in the processes of OSS development and testing. Compared with other models, the proposed model has better fitting and predictive performance. We also give a simple OSS optimal release method considering the testing‐effort and reliability changes in the processes of OSS development and testing. The proposed model and optimized release method can effectively assist OSS developers to evaluate software reliability and determine the optimal release time.
Gastro‐intestinal parasites of sympatric red panda and livestock in protected areas of Nepal
Authors: Sharma Hari Prasad , Achhami Bishnu 
Published: October 2021

AbstractBackgroundDisease transmission among humans, domestic animals and wildlife can have profound consequences in human health, wildlife conservation and maintenance of biodiversity. The issue of disease transmission can be particularly important for threatened wildlife species, yet such information remains scarce due to logistic constraints and government regulation on animal handlings. The red panda (Ailurus fulgens) is one of the globally threatened species challenged with habitat fragmentation and human disturbance. In Nepal, livestock grazing is recognised as one of the major threats to the red panda.AimWe aimed to provide the first empirical data on gastro‐intestinal parasites for sympatric livestock and red panda from two geographically isolated regions in Nepal.MethodsIn this study, we systematically sampled, and examined the faecal of livestock and red panda in two separate protected areas to provide the first empirical data on their gastro‐intestinal parasite, including the prevalence, parasite richness and load.ResultsWe documented 11 parasite taxa (7 nematodes, 2 cestodes, 1 trematode and 1 coccidian), of which 8 are shared by both livestock and red panda. Furthermore, parasite prevalence, parasite load and parasite richness were generally higher in the livestock than the red panda.ConclusionThe data provided from this systematic survey on parasites of sympatric livestock and red panda in wild raises the concern about the potential role of livestock mediating disease dynamics in the red panda. Our study suggests that cross‐transmission of parasites between livestock and red panda are likely, and the livestock may be a competent agent bringing disease to both red panda and human. Therefore, managing human‐livestock‐wildlife contact to reduce disease risk to all groups should be a key component in conservation planning of protected areas.
Retrospective evaluation of nimustine use in the treatment of feline lymphoma
Authors: Sakai Kosei , Hatoya Shingo , Furuya Masaru , Nabetani Tomoyo , Kanegi Ryoji , Shimamura Shunsuke , Tani Hiroyuki , Shimada Terumasa 
Published: October 2021

AbstractBackgroundNimustine, similar to lomustine, is an alkylating agent from the nitrosourea family. There have been some reports regarding lomustine treatment for tumour‐bearing cats. However, information regarding nimustine treatment for tumour‐bearing cats is limited.ObjectivesTo retrospectively evaluate adverse events and clinical outcomes in tumour‐bearing cats receiving nimustine.MethodsInformation regarding diagnosis, treatment condition, adverse events, and clinical outcomes was collected in tumour‐bearing cats receiving nimustine through reviews of medical records.ResultsNine cats with lymphoma were treated with nimustine in the primary therapy (n = 2) and in the rescue therapy (n = 7). Median starting dose of nimustine was 25 mg/m2 (range: 20–30 mg/m2) with dosing interval of three weeks and 1–11 administrations. Adverse events were mild gastrointestinal toxicity (grade 1) including diarrhoea (n = 2) and vomiting (n = 2) and mild myelosuppression (grade 1 or 2) including thrombocytopenia (n = 3) and neutropenia (n = 1). No severe adverse events were observed. Progression‐free survival durations among cats receiving nimustine in the primary therapy and in the rescue therapy were 274–688 days (median: 481 days) and 9–671 days (median: 102 days), respectively. Overall survival durations among cats receiving nimustine in the primary therapy and in the rescue therapy were 275–745 days (median: 510 days) and 14–671 days (median: 109 days), respectively.ConclusionsNimustine was well tolerated and showed clinical outcomes similar to lomustine in cats with lymphoma. These findings suggest that nimustine might be an alternative to lomustine in the treatment of feline lymphoma.
Thinking probabilistically in the study of intonational speech prosody
Authors: Kurumada Chigusa , Roettger Timo B. 
Published: October 2021

AbstractSpeech prosody, the melodic and rhythmic properties of a language, plays a critical role in our everyday communication. Researchers have identified unique patterns of prosody that segment words and phrases, highlight focal elements in a sentence, and convey holistic meanings and speech acts that interact with the information shared in context. The mapping between the sound and meaning represented in prosody is suggested to be probabilistic—the same physical instance of sounds can support multiple meanings across talkers and contexts while the same meaning can be encoded in physically distinct sound patterns (e.g., pitch movements). The current overview presents an analysis framework for probing the nature of this probabilistic relationship. Illustrated by examples from the literature and a dataset of German focus marking, we discuss the production variability within and across talkers and consider challenges that this variability imposes on the comprehension system. A better understanding of these challenges, we argue, will illuminate how the human perceptual, cognitive, and computational mechanisms may navigate the variability to arrive at a coherent understanding of speech prosody. The current paper is intended to be an introduction for those who are interested in thinking probabilistically about the sound‐meaning mapping in prosody. Open questions for future research are discussed with proposals for examining prosodic production and comprehension within a comprehensive, mathematically‐motivated framework of probabilistic inference under uncertainty.This article is categorized under:Linguistics > Language in Mind and BrainPsychology > Language
Patient-specific resurfacing implant knee surgery in subjects with early osteoarthritis results in medial pivot and lateral femoral rollback during flexion: a retrospective pilot study
Authors: Moewis Philippe , Kaiser René , Trepczynski Adam , von Tycowicz Christoph , Krahl Leonie , Ilg Ansgar , Holz Johannes , Duda Georg N. 
Published: October 2021

Abstract
Purpose
Metallic resurfacing implants have been developed for the treatment of early, small, condylar and trochlear osteoarthritis (OA) lesions. They represent an option for patients who do not fulfill the criteria for unicompartmental knee arthroplasty (UKA) or total knee arthroplasty (TKA) or are too old for biological treatment. Although clinical evidence has been collected for different resurfacing types, the in vivo post-operative knee kinematics remain unknown. The present study aims to analyze the knee kinematics in subjects with patient-specific episealer implants. This study hypothesized that patient-specific resurfacing implants would lead to knee kinematics close to healthy knees, resulting in medial pivot and a high degree of femoral rollback during flexion.

Methods
Retrospective study design. Fluoroscopic analysis during unloaded flexion–extension and loaded lunge was conducted at > 12 months post-surgery in ten episealer knees, and compared to ten healthy knees. Pre- and post-operative clinical data of the episealer knees were collected using a visual analog scale (VAS), the EQ 5d Health, and the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaires.

Results
A consistent medial pivot was observed in both episealer and healthy knees. Non-significant differences were found in the unloaded (p = 0.15) and loaded (p = 0.51) activities. Although lateral rollback was observed in both groups, it was significantly higher for the episealer knees in both the unloaded (p = 0.02) and loaded (p = 0.01) activities. Coupled axial rotation was significantly higher in the unloaded (p = 0.001) but not in the loaded (p = 0.06) activity in the episealer knees. Improved scores were observed at 1-year post-surgery in the episealer subjects for the VAS (p = 0.001), KOOS (p = 0.001) and EQ Health (p = 0.004).

Conclusion
At 12 month follow-up, a clear physiological knee kinematics pattern of medial pivot, lateral femoral rollback and coupled axial external femoral rotation during flexion was observed in patients treated with an episealer resurfacing procedure. However, higher femoral rollback and axial external rotation in comparison to healthy knees was observed, suggesting possible post-operative muscle weakness and consequent insufficient stabilization at high flexion.