bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of child development at primary school entry on adolescent health—protocol for a participatory systematic review
Authors: Black Michelle , Barnes Amy , Strong Mark , Taylor-Robinson David 
Published: May 2021

Abstract
Background
Reducing child health inequalities is a global health priority and evidence suggests that optimal development of knowledge, skills and attributes in early childhood could reduce health risks across the life course. Despite a strong policy rhetoric on giving children the ‘best start in life’, socioeconomic inequalities in children’s development when they start school persist. So too do inequalities in child and adolescent health. These in turn influence health inequalities in adulthood. Understanding how developmental processes affect health in the context of socioeconomic factors as children age could inform a holistic policy approach to health and development from childhood through to adolescence. However, the relationship between child development and early adolescent health consequences is poorly understood. Therefore the aim of this review is to summarise evidence on the associations between child development at primary school starting age (3–7 years) and subsequent health in adolescence (8–15 years) and the factors that mediate or moderate this relationship.

Method
A participatory systematic review method will be used. The search strategy will include; searches of electronic databases (MEDLINE, PsycINFO, ASSIA and ERIC) from November 1990 onwards, grey literature, reference searches and discussions with stakeholders. Articles will be screened using inclusion and exclusion criteria at title and abstract level, and at full article level. Observational, intervention and review studies reporting a measure of child development at the age of starting school and health outcomes in early adolescence, from a member country of the Organisation for Economic Co-operation and Development, will be included. The primary outcome will be health and wellbeing outcomes (such as weight, mental health, socio-emotional behaviour, dietary habits). Secondary outcomes will include educational outcomes. Studies will be assessed for quality using appropriate tools. A conceptual model, produced with stakeholders at the outset of the study, will act as a framework for extracting and analysing evidence. The model will be refined through analysis of the included literature. Narrative synthesis will be used to generate findings and produce a diagram of the relationship between child development and adolescent health.

Discussion
The review will elucidate how children’s development at the age of starting school is related to subsequent health outcomes in contexts of socioeconomic inequality. This will inform ways to intervene to improve health and reduce health inequality in adolescents. The findings will generate knowledge of cross-sector relevance for health and education and promote inter-sectoral coherence in addressing health inequalities throughout childhood.

Protocol Registration
This systematic review protocol has been registered with PROSPERO CRD42020210011.
Effect of forest fire on soil microbial biomass and enzymatic activity in oak and pine forests of Uttarakhand Himalaya, India
Authors: Singh Devanshi , Sharma Priyanka , Kumar Ujjwal , Daverey Achlesh , Arunachalam Kusum 
Published: May 2021

Abstract
Background
Forest fire incidences in the Himalayan region of Uttarakhand, India are very common in summers. Pine and oak are the principal and dominant species of Himalayan subtropical forest and Himalayan temperate forest, respectively. Forest vegetation influences the physicochemical and biological properties of soil and forest fire in pine and oak forests may have a different effect on the physicochemical and biological properties of soil. Therefore, the present study was carried out to assess the impact of forest fire on soil microbial properties, enzymatic activity, and their relationship with soil physicochemical properties in the advent of forest fire in the pine and oak forests of the Garhwal region of Uttarakhand Himalaya, India.

Results
The soil microbial biomass carbon and nitrogen, soil basal respiration, and acid phosphatase activity decreased, whereas dehydrogenase activity increased at burnt sites of both forest types. The overall change in soil microbial biomass carbon was 63 and 40% at the burnt oak forest and burnt pine forest, respectively. Dehydrogenase activity and acid phosphatase activity showed a strong positive correlation with soil organic matter (r = 0.8) and microbial indices, respectively. The ratio of soil microbial biomass carbon/nitrogen was reduced at burnt sites of both forest types. Factor analysis results showed that fire had a significant impact on soil characteristics. The soil basal respiration was linked with macro- and micronutrients at burnt sites, whereas at control sites, it was linked with physicochemical properties of soil along with nutrients.

Conclusion
Forest fire had a significant impact on soil properties of both forest types. The impact of forest fire on soil microbial biomass carbon was stronger in the oak forest than in the pine forest. Forest type influenced soil enzymatic activity at burnt sites. The bacterial community was dominated over fungi in burnt sites of both forests. Soil microbial indices can be used as a selective measure to assess the impact of fire. Furthermore, forest type plays an important role in regulating the impact of forest fire on soil properties.
An application of slow feature analysis to the genetic sequences of coronaviruses and influenza viruses
Authors: Tsonis Anastasios A. , Wang Geli , Zhang Lvyi , Lu Wenxu , Kayafas Aristotle , Del Rio-Tsonis Katia 
Published: May 2021

Abstract
Background
Mathematical approaches have been for decades used to probe the structure of nucleotide sequences. This has led to the development of Bioinformatics. In this exploratory work, a novel mathematical method is applied to probe the genetic structure of two related viral families: those of coronaviruses and those of influenza viruses. The coronaviruses are SARS-CoV-2, SARS-CoV-1, and MERS. The influenza viruses include H1N1-1918, H1N1-2009, H2N2-1957, and H3N2-1968.

Methods
The mathematical method used is the slow feature analysis (SFA), a rather new but promising method to delineate complex structure in nucleotide sequences.

Results
The analysis indicates that the nucleotide sequences exhibit an elaborate and convoluted structure akin to complex networks. We define a measure of complexity and show that each nucleotide sequence exhibits a certain degree of complexity within itself, while at the same time there exists complex inter-relationships between the sequences within a family and between the two families. From these relationships, we find evidence, especially for the coronavirus family, that increasing complexity in a sequence is associated with higher transmission rate but with lower mortality.

Conclusions
The complexity measure defined here may hold a promise and could become a useful tool in the prediction of transmission and mortality rates in future new viral strains.
Strongyloidiasis: the most neglected tropical disease in Ethiopia
Authors: Tiruneh Abebaw , Zemene Endalew , Mekonnen Zeleke 
Published: May 2021

Abstract
Background
Strongyloidiasis is the most neglected of the neglected tropical diseases (NTDs). The aim of this commentary is to describe the possible reasons why strongyloidiasis is so overlooked in Ethiopia, and shed light on better ways of control and elimination of the disease.

Main body
This commentary highlights three points why strongyloidiasis is the most neglected of the NTDs in Ethiopia. Firstly, lack of clear category within the NTDs resulted in omission of the disease from reports, intervention programs, and preventive chemotherapy guidelines. Secondly, magnitude of the disease is underestimated due to paucity of studies and low sensitivity of diagnostic methods coupled with asymptomatic nature of most of the infections. Finally, ivermectin (the drug of choice for treatment of strongyloidiasis) is not in use for control of the other soil-transmitted helminthiasis, nor is there ivermectin mass drug administration for control of strongyloidiasis. This might have created gap in control and elimination of the disease in Ethiopia and possibly elsewhere.

Conclusion
Strongyloidiasis appears to be the most neglected of the NTDs mainly due to nature of the infection, low sensitivity of the routine diagnostic tools and it’s exclusion from strategic plans and intervention programs. Moreover, studies on strongyloidiasis should use sensitive diagnostic tools. Strongyloidiasis control and elimination programs should be based on reliable evidence of epidemiology of the disease in Ethiopia.

Graphic Abstract
Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice
Authors: Furihata Takaaki , Maekawa Satoshi , Takada Shingo , Kakutani Naoya , Nambu Hideo , Shirakawa Ryosuke , Yokota Takashi , Kinugawa Shintaro 
Published: May 2021

Abstract
Background
Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be associated with a high cumulative dose of DOX, the mechanisms of its long-term effects have not been completely elucidated. Pioglitazone (Pio) is presently contraindicated in patients with symptomatic heart failure owing to the side effects. The concept of drug repositioning led us to hypothesize the potential effects of Pio as a premedication before DOX treatment, and to analyze this hypothesis in mice.

Methods
First, for the hyperacute (day 1) and acute (day 7) DOX-induced dysfunction models, mice were fed a standard diet with or without 0.02% (wt/wt) Pio for 5 days before DOX treatment (15 mg/kg body weight [BW] via intraperitoneal [i.p.] administration). The following 3 treatment groups were analyzed: standard diet + vehicle (Vehicle), standard diet + DOX (DOX), and Pio + DOX. Next, for the chronic model (day 35), the mice were administrated DOX once a week for 5 weeks (5 mg/kg BW/week, i.p.).

Results
In the acute phase after DOX treatment, the percent fractional shortening of the left ventricle (LV) was significantly decreased in DOX mice. This cardiac malfunction was improved in Pio + DOX mice. In the chronic phase, we observed that LV function was preserved in Pio + DOX mice.

Conclusions
Our findings may provide a new pathophysiological explanation by which Pio plays a role in the treatment of DOX-induced cardiomyopathy, but the molecular links between Pio and DOX-induced LV dysfunction remain largely elusive.
Out of fright, out of mind: impaired memory for information negated during looming threat
Authors: Newman Vera E. , Yee Hannah F. , Walker Adrian R. , Toumbelekis Metaxia , Most Steven B. 
Published: May 2021

AbstractPeople often need to update representations of information upon discovering them to be incorrect, a process that can be interrupted by competing cognitive demands. Because anxiety and stress can impair cognitive performance, we tested whether looming threat can similarly interfere with the process of updating representations of a statement’s truthfulness. On each trial, participants saw a face paired with a personality descriptor. Each pairing was followed by a signal indicating whether the pairing was “true”, or “false” (a negation of the truth of the statement), and this signal could be followed by a warning of imminent electric shock (i.e., the looming threat). As predicted, threat of shock left memory for “true” pairings intact, while impairing people’s ability to label negated pairings as untrue. Contrary to our predictions, the pattern of errors for pairings that were negated under threat suggested that these mistakes were at least partly attributable to participants forgetting that they saw the negated information at all (rather than being driven by miscategorization of the pairings as true). Consistent with this, linear ballistic accumulator modelling suggested that this impaired recognition stemmed from weaker memory traces rather than decisional processes. We suggest that arousal due to looming threat may interfere with executive processes important for resolving competition between mutually suppressive tags of whether representations in memory are “true” or “false”.
Kinetic comparative study on aerodynamic characteristics of hypersonic reentry vehicle from near-continuous flow to free molecular flow
Authors: Li Jin , Jiang Dingwu , Geng Xiangren , Chen Jianqiang 
Published: May 2021

AbstractA scaled model of the X38-like configuration was simulated under hypersonic conditions for the direct simulation Monte Carlo method and the unified gas kinetic scheme. The inflow conditions considered several flow regimes, from the near-continuum through the slip-transitional to the free molecular regime. Flow fields and surface properties were compared in detail between these two methods. Not only the density and temperature contours distribution but also the surface pressure, heat flux, friction distribution, both kinetic methods give fairly consistent results. Aerodynamics of the model were also achieved and compared. The results provided by both methods agreed with each other very well. The effects of the Knudsen number and angle of attack were assessed. It is meaningful to carry out comparative studies and accelerate both methods to further progress.
Bias in expert witness practice: sources, routes to expression and how to minimise it
Authors: Eastman Nigel , Rix Keith 
Published: May 2021

SUMMARYThe expert witness practice of psychiatrists is under constant scrutiny by the courts and, in the UK, the General Medical Council, as well as within appraisal and revalidation as part of a doctor's overall practice. Regulation and appraisal of expert witness practice must address not only technical competence, including demonstration of a real understanding of the interface between medicine and law, but also ethical probity, including in respect of bias, which is the most challenging appraisal focus. In psychiatry, there is much room for ‘values expression’, and therefore bias, in the offering of expert opinion. This article first describes various legal and psychological definitions of bias; then addresses the sources and routes to expression of bias within expert witness practice, viewed legally, psychologically and neuroscientifically. Finally, it proposes ways in which inevitable bias can be minimised by the individual practitioner.
The Effect of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Therapy on Skeletal Muscle Lipid Content in Obese and Nonobese Men
Authors: Koenig Alexander M , Koehler Ulrich , Hildebrandt Olaf , Schwarzbach Hans , Hannemann Lena , Boneberg Raphael , Heverhagen Johannes T , Mahnken Andreas H , Keller Malte , Kann Peter H , Deigner Hans-Peter , Laur Nico , Kinscherf Ralf , Hildebrandt Wulf 
Published: May 2021

Abstract
Obstructive sleep apnea (OSA), independently of obesity (OBS), predisposes to insulin resistance (IR) for largely unknown reasons. Because OSA-related intermittent hypoxia triggers lipolysis, overnight increases in circulating free fatty acids (FFAs) including palmitic acid (PA) may lead to ectopic intramuscular lipid accumulation potentially contributing to IR. Using 3-T-1H-magnetic resonance spectroscopy, we therefore compared intramyocellular and extramyocellular lipid (IMCL and EMCL) in the vastus lateralis muscle at approximately 7 am between 26 male patients with moderate-to-severe OSA (17 obese, 9 nonobese) and 23 healthy male controls (12 obese, 11 nonobese). Fiber type composition was evaluated by muscle biopsies. Moreover, we measured fasted FFAs including PA, glycated hemoglobin A1c, thigh subcutaneous fat volume (ScFAT, 1.5-T magnetic resonance tomography), and maximal oxygen uptake (VO2max). Fourteen patients were reassessed after continuous positive airway pressure (CPAP) therapy. Total FFAs and PA were significantly (by 178% and 166%) higher in OSA patients vs controls and correlated with the apnea-hypopnea index (AHI) (r ≥ 0.45, P &lt; .01). Moreover, IMCL and EMCL were 55% (P &lt; .05) and 40% (P &lt; .05) higher in OSA patients, that is, 114% and 103% in nonobese, 24.4% and 8.4% in obese participants (with higher control levels). Overall, PA, FFAs (minus PA), and ScFAT significantly contributed to IMCL (multiple r = 0.568, P = .002). CPAP significantly decreased EMCL (–26%) and, by trend only, IMCL, total FFAs, and PA. Muscle fiber composition was unaffected by OSA or CPAP. Increases in IMCL and EMCL are detectable at approximately 7 am in OSA patients and are partly attributable to overnight FFA excesses and high ScFAT or body mass index. CPAP decreases FFAs and IMCL by trend but significantly reduces EMCL.
Comparison of tillage costs among eight paddy farm regions in East Kalimantan, Indonesia
Authors: Karmini Karmini , Karyati Karyati 
Published: May 2021

Background: Tillage is done to prepare land for wetland paddy farming, and it is commonly done by hand tractor. The purposes of this study were to identify the levels of ownership of hand tractor by paddy farmers, to describe the rental of hand tractor in rural areas, to calculate and compare the tillage costs on eight paddy farm regions, and to understand the utilization of farm machinery for paddy farming in East Kalimantan, Indonesia. Methods: The study areas were Subcities/Subregencies of North Bontang, South Bontang, Muara Muntai, Loa Janan, Tenggarong Seberang, Waru, Penajam, and Babulu. Data collection was done by interviewing 380 respondents. Analysis of data used descriptive statistics, the Chi Square One Sample test, and One Way Anova. Results: The number of hand tractor renters (87.37%) in East Kalimantan 2014 was bigger than that of hand tractor owners (12.63%). The tillage costs in Tenggarong Seberang, Loa Janan, and Muara Muntai in 2014 were USD48.56 ha-1, USD52.03 ha-1, and USD48.56 ha-1, respectively. Tillage costs were the same in Babulu, Penajam, Waru, South Bontang, and North Bontang (USD69.37 ha-1 in each regency). Conclusions: There are very significant differences the number of hand tractor owners, the number of hand tractor renters, and the tillage costs among some regions in East Kalimantan, Indonesia. Farm machinery is needed in development of paddy farming.
Identification of potential inhibitors of SARS-CoV-2 S protein–ACE2 interaction by in silico drug repurposing
Authors: Tristán-Flores Fabiola E , Casique-Aguirre Diana , Pliego-Arreaga Raquel , Cervantes-Montelongo Juan A , García-Gutierrez Ponciano , Acosta-García Gerardo , Silva-Martínez Guillermo A 
Published: May 2021

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new coronavirus discovered that appeared in Wuhan, China, in December 2019, causes COVID-19 disease which have resulted in cases similar to SARS-atypical pneumonia. As of March 1, 2021, Mexico had reached 2.11 million cases of COVID-19 and 189 thousand deaths; around 116 million cases and 2.57 million deaths are reported worldwide with new cases and increasing mortality every day. To date, there is no specific commercial treatment to control the infection. Repurpose drugs targeting the angiotensin-converting enzyme 2 (ACE2) receptor represents an alternative strategy to block the binding of SARS-CoV-2 protein S and forestall virus adhesion, internalization and replication in the host cell. Methods: Rigid molecular docking was performed using receptor binding domain of the S1 subunit of S protein (RBDS1)-ACE2 (PDB ID: 6VW1) interaction site and 1,283 drugs FDA approved and prescribed by the Mexican Public Health System. The results were analyzed by docking score, frequency of the drug in receptor site and the types of interactions at the binding site residues. Results: About 40 drugs were identified as a potential inhibitor of RBDS1-ACE2 interaction. Within the top-ranked drugs, we identified ipratropium, formoterol and fexofenadine, which stands out as they are used as therapies to treat chronic obstructive pulmonary disease, asthma and virtually any respiratory infection. Conclusions: Our results will serve as the basis for in vitro and in vivo studies to evaluate the potential use of those drugs to generate affordable and convenient therapies to treat COVID-19.
Local knowledge of Karangwangi People of Cianjur District, West Java, Indonesia on water pollution of the Cikawung River
Authors: PRIMADIANI DINI , ISKANDAR JOHAN , SUNARDI SUNARDI 
Published: May 2021

Abstract. Primadiani D, Iskandar J, Sunardi. 2018. Local knowledge of Karangwangi People of Cianjur District, West Java, Indonesia on water pollution of the Cikawung River. Asian J Ethnobiol 1: 9-14. In the past, village people of Karangwangi, Cianjur District, West Java Province did not face any problem of water supply, including supply from the Cikawung River. Of late, however, they are experiencing problems with water sources, particularly water supply from the Cikawung River. Since pesticides have been intensively used in the local agroecosystems, such as irrigated rice fields and monoculture vegetable gardens, the Cikawung river water is polluted. In addition, the consequences of increase in conversion of forests and traditional mixed-gardens into agricultural and settlement areas have dramatically affected hydrological balances. On this background, this research was carried out to elucidate the local knowledge of the Karangwangi people on the status of pollution of water of the Cikwaung river. This research used a mix of qualitative and quantitative methods with descriptive qualitative analysis. Qualitative data collection technique used was deep interviews with informants chosen purposely with snowball sampling. Quantitative data collection technique was interview with respondents using questionnaires and measurement of physical, chemical and biology parameters of Cikawung River water. Results of this research confirm that village people of Karangwangi have considerable local knowledge on water categorization, pollution and pollution indicators of Cikawung River
Rugged diode-pumped Alexandrite laser as an emitter in a compact mobile lidar system for atmospheric measurements
Authors: Munk Alexander , Strotkamp Michael , Jungbluth Bernd , Froh Jan , Mense Thorben , Mauer Alsu , Höffner Josef 
Published: May 2021

We present design and performance data of two diode-pumped Alexandrite lasers developed explicitly as laser emitters in mobile potassium resonance lidar systems. The lasers yield an output power of up to 1.75 mJ at a repetition rate of 500 Hz with a beam quality of

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in both spatial directions. Reliable single longitudinal mode operation with a unrivaled narrow linewidth of 3.3 MHz at a potassium resonance line at 769.898 nm is achieved. The wavelength can be switched from pulse to pulse in a range of several gigahertz so the potassium line can be scanned. The lasers are finally integrated in highly efficient lidar systems with a power consumption of 500 W for the whole lidar system. The extremely high spectral requirements are investigated and the performance for different working points regarding repetition rates and pump durations is investigated. Several weeks of remotely controlled operation of the prototype in a field campaign were conducted without changes of the output parameters. Approximately 1000 h of reliable single longitudinal mode operation was achieved during the campaign and measurements of Doppler–Mie wind observations in the stratosphere and of the potassium layer in the mesopause were conducted simultaneously even at daytime.