bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of AXL and mTOR genes expression in medullary thyroid carcinoma (MTC) cell line in relation with over expression of miR-144 and miR-34a
Authors: Pishkari Shaghayegh , Hadavi Razie , Koochaki Ameneh , Razaviyan Javad , Paryan Mahdi , Hashemi Mehrdad , Mohammadi-Yeganeh Samira 
Published: March 2021

Abstract

Objectives
The aim of the present study was to investigate the expression of AXL and mTOR genes and their targeting microRNAs (miRNAs) including miR-34a and miR-144 in Medullary Thyroid Carcinoma (MTC) cell line, TT, and determine the effect of these two miRNAs on their target genes to introduce new molecular markers or therapeutics.

Methods
The expression of miR-34a, miR-144, and their targets genes including AXL and mTOR was evaluated by quantitative Real-time PCR. Luciferase assay was performed to confirm the interaction between miRNAs and their target mRNAs. The expression level of AXL and mTOR was evaluated before and after miRNAs induction in TT cell line compared with Cos7 as control cells.

Results
The expression of AXL and mTOR were up-regulated significantly, while miR-34a and miR-144 were down-regulated in TT cell line compared to Cos7. After transduction, the overexpression of miR-34a and 144 caused down-regulation of both genes. Luciferase assay results showed that the mTOR is targeted by miR-34a and miR-144 and the intensity of luciferase decreased in the presence of miRNAs.

Conclusions
Based on the results of the present study and since AXL and mTOR genes play a critical role in variety of human cancers, suppression of these genes by their targeting miRNAs, especially miR-34a and miR-144, can be propose as a new strategy for MTC management. However, more studies are needed to approve the hypothesis.
A data and knowledge driven approach for SPECT using convolutional neural networks and iterative algorithms
Authors: Ao Wenqi , Li Wenbin , Qian Jianliang 
Published: March 2021

Abstract
We propose a data and knowledge driven approach for SPECT by combining a classical iterative algorithm of SPECT with a convolutional neural network.
The classical iterative algorithm, such as ART and ML-EM, is employed to provide the model knowledge of SPECT.
A modified U-net is then connected to exploit further features of reconstructed images and data sinograms of SPECT.
We provide mathematical formulations for the architecture of the proposed networks.
The networks are trained by supervised learning using the technique of mini-batch optimization.
We apply the trained networks to the problems of simulated lung perfusion imaging and simulated myocardial perfusion imaging, and numerical results demonstrate their effectiveness of reconstructing source images from noisy data measurements.
Probing of the genetic components of seedling emergence traits as selection indices, and correlation with grain yield characteristics of some tropical maize varieties
Authors: Ige Sunday Ayodele , Bello Omolaran , Charity Aremu , Stephen Abolusoro 
Published: March 2021

Abstract
Ten maize varieties of tropical origin were tested at two different agro-ecological zones during the cropping season of 2007 and 2008 to investigate the genetic components of seedling emergence characteristic and correlate with grain yield and related traits in Nigeria. Heritability values were high for all traits study, indicating reliability and stability of most of the traits across different environments. Variety DMRLSR-Y had highest 300 kernel weight (105.2 g), but least grain yield and second to the least emergence percentage, indicating bigger kernel and highest kernel weight/cob but low plant stands resulted in low grain yield. Genotypic and agronomic correlation analysis revealed positive associations (p < 0.01) between grain yield and emergence percentage (E%), and 300 kernel weight; however, interval between pollen shed and silking was negatively correlated with physiological maturity period and 300 kernel weight. Improvement of this variety for higher emergence percentage is therefore predicted for higher grain yield. High values of genotypic and phenotypic coefficient of variation recorded by emergence percentage (41 and 45%) and grain yield (25 and 32%), respectively, revealed the less effects of environmental factors on the aforementioned characters, and it showed the stability and reliability of the two traits. High values of both broad sense heritability and genetic advance recorded by emergence percentage (E%) and 300 kernel weight confirmed that standard selection procedure could be used to identify superior genotypes for the two traits.
Preparation and heat insulation of Gemini-halloysite aerogel/concrete composites
Authors: Li Hongyan , Zang Pengfei , Liu Hongli , Cao Kai , Liao Xiaolan , Wei Dongqing , Zhang Bo , Li Huan , Wang Jiangang 
Published: March 2021

Abstract
In our previous research, the utilization of Gemini surfactants to control the dispersion and interaction of HNTs aerogels (HCAs) in the concrete matrix had obtained positive research results. In order to further deepen the research in this field, in this work, a Gemini surfactant with a new structure was synthesized, the surface modification characteristics of HCAs in a series of concrete systems were also investigated. Microstructures and properties of the composites were characterized by using scanning electron microscope (SEM), Fourier transform infrared (FTIR), Thermogravimetric analysis (TGA), and so on. The results showed that the newly synthesized Gemini surfactants had an ideal modification effect on the surface of HCAs. Compared with other traditional surfactants, Gemini had better hydrophobic and mechanical properties. Different molecular layers with hydrophilicity or hydrophobicity were constructed on the HCAs surface. The introduction of the modified HCAs could significantly improve the heat insulation performance and mechanical strength of concrete. The improvement of the above comprehensive properties could not have significant difference due to the different types of concrete matrix.
Study of oxaliplatin penetration into ovaries of patients treated with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases of colorectal and appendiceal origin using mass spectrometry imaging
Authors: Larroque Marion , Mounicou Sandra , Sgarbura Olivia , Arnaudguilhem Carine , Rebel Lucie , Leaha Cristina , Faye Pierre-Arnaud , Enjalbal Christine , Quénet François , Bouyssiere Brice , Carrere Sébastien 
Published: March 2021

Abstract

Objectives
Platinum salts are commonly used in hyperthermic intraperitoneal chemotherapy (HIPEC) for digestive tract cancer treatment. During HIPEC with oxaliplatin for peritoneal metastases (PMs) treatment, the ovaries are directly exposed to the drug, questioning about ovarian resection and the potential impact of the drug on ovarian functionality, especially in young women of childbearing age. The goal of this work is to understand unwanted damages to the ovaries during HIPEC therapy by the determination of the concentration and distribution of platinum in ovaries in order to address its potential toxicity.

Methods
Mass spectrometry imaging techniques, matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP MS), were used to study the penetration of oxaliplatin in ovaries after HIPEC treatment.

Results
MALDI-MS allowed the localization of an oxaliplatin-derivative (m/z 456.2) at the periphery of the ovaries. The quantitative LA-ICP MS maps confirmed the localization of elemental platinum as well as in the central part of ovaries from patients who received a previous platinum salt-based chemotherapy.

Conclusions
LA-ICP MS images showed that platinum diffusion was extended in cases of previous systemic treatment, questioning about platinum derivatives gonado-toxicity when combining the two treatments.
Gellan Gum Hydrogel as an Aqueous Treatment Method for Xuan Paper
Authors: Li Haomiao , Severini Leonardo , Titubante Mattia , Gong Decai , Micheli Laura , Mazzuca Claudia , Gong Yuxuan 
Published: March 2021

Abstract
Aqueous cleaning of works of art on paper is one of the most important and delicate steps in a conservation process. It allows the removal of inorganic (metals) and organic substances, such as degradation products and other contaminants. These substances are responsible for yellowing, weakening, and loss of mechanical properties of paper. In this article, the cleaning effect of gellan gum was assessed on xuan paper, a traditional Chinese paper different in composition and papermaking technology compared to many Western papers. To assess the effect of gellan gum on xuan paper, its characteristics were studied before and after cleaning utilizing non-invasive and micro-invasive techniques. Results were compared to those obtained when treating Western papers and indicated that gellan gum can be applied effectively for aqueous cleaning of xuan paper.
The manner of use, the uses and sub-uses of terms in social sciences: from the functional approach to natural language to applied semiotics and the philosophy of science
Authors: Węsierski Michał Roman 
Published: March 2021

Abstract
The functional approach to natural language (FANL) emerged in the late 1960s. It focused on the use and the sub-use of language expressions, taking into account role of the language context and the extra-linguistic situation of a given statements. This approach referred, both conceptually and methodologically, to the tradition of British analytical philosophy of language on the one hand, and to the achievements of the Lvov-Warsaw School on the other. It seems that despite the passage of more than half a century since its inception, this approach has lost nothing of its relevance and its cognitive value, and may even provide inspiration for the exploration new research areas concerning the formulation of language utterances. The aim of this article is to show the potential applications of the FANL as a specific semiotic concept in the field of the philosophy of social sciences. The paper points out how the functional conception can be successfully used in methodological analyses of the logical methodology of social sciences. The case studies presented in the article refer to the research practice of social sciences. Examples of the use and sub-uses of terms are discussed in the light of the polyparadigmatic structure of social sciences and the differences in research patterns accepted by given scientific collectives.
Direct-imaging DOEs for high-NA multi-spot confocal surface measurement
Authors: Li Zheng , Taphanel Miro , Längle Thomas , Beyerer Jürgen 
Published: March 2021

Abstract
Diffractive lens arrays with overlapping apertures can produce spot arrays with high numerical apertures (NAs). Combined with low-NA objectives, they can measure a large area with high lateral resolution. However, for surface measurements, the axial resolution of such setups is still fundamentally limited by the objectives. In this work, we propose a new design of diffractive optical elements (DOEs) to overcome this problem. The proposed Direct-imaging DOEs can perform 3D high-NA multi-spot surface measurements. Laterally, a non-vanishing contrast up to 1448 lp/mm is measured with a USAF resolution target. Axially, an average height of 917.5 nm with a standard deviation of 49.9 nm is measured with a calibrated step height target of 925.5 nm.
Impact of salts on the phase separation and thermodynamic properties of mixed nonionic surfactants in absence/attendance of polyvinyl alcohol
Authors: Ali Md. Ackas , Amin Md. Ruhul , Mahbub Shamim , Hossen Md. Delwar , Hoque Md. Anamul , Kumar Dileep 
Published: March 2021

Abstract
Mixed surfactant systems are used in different applied fields like pharmaceutical formulation rather than single surfactant. Therefore, the determination of the clouding nature of the triton X-100 (TX-100) + Tween 80 (TW-80) mixture was carried out in H2O and polyvinyl alcohol (PVA). In the occurrence of PVA, the cloud point (CP) values of TX-100 initially enhance with enhancing the concentration of PVA and tend to decrease after a certain concentration. For different ratios of TX-100 and TW-80 mixture having the same concentration of both solutions, CP values increase through the decreasing ratios of TX-100 with/without PVA. In the presence of polymer, at higher ratios of TX-100 than TW-80, the CP values are higher in magnitudes in comparison to the aqueous medium but at lower ratios of TX-100, the value of CP are lower in magnitudes in comparison to the aqueous system. The CP values of the TX-100 + TW-80 mixture in the salt system are lower in magnitudes than the aqueous medium in both the absence/presence of PVA. However, a reduction of CP values was obtained to a large extent for Na2SO4 over NaCl in the case of lower volume ratios of TX-100. Various thermodynamic variables (standard free energy (

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${\Delta}{G}_{c}^{o}$

), standard enthalpy (

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o

${\Delta}{H}_{c}^{o}$

), standard entropy (

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) change, thermodynamic parameters of transfer (free energy of transfer (

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,
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${\Delta}{G}_{c,t}^{o}$

), and transfer of enthalpies (

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,
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)) of phase transition) were also determined.
Holistische Planung einer Fertigung im Neubau
Authors: Häfner Victor , Benedix Anne-Christine , Grethler Michael , Kögel Manuela 
Published: March 2021

Abstract
Starke Fragmentierung von Kompetenzen führt besonders bei Großbauprojekten zu Problemen. Ziel unseres Ansatzes ist es, Planungsprozesse und -daten zu analysieren und in einen gemeinsamen Kontext zu integrieren. So ist eine kontinuierliche virtuelle Validierung der integralen Projektplanung möglich. Ausgehend von Planungsdaten der Architekten und Gewerke wurde das 3D-Layout der geplanten Produktionsstätte in die Gebäudeplanung integriert, während sich das eigentliche Gebäude noch im Bau befindet.**)
Bone mineral density during 3 years of growth hormone in previously GH-treated young adults with PWS
Authors: Damen Layla , Grootjen Lionne N , Donze Stephany H , de Graaff Laura C G , van der Velden Janielle A E M , Hokken-Koelega Anita C S 
Published: March 2021

Objective
In children with Prader–Willi syndrome (PWS), growth hormone (GH) treatment has positive effects on bone mineral density (BMD). Two 1-year studies did not show a difference between GH or placebo on BMD in young adults with PWS. However, there are no studies investigating BMD during longer-term GH treatment in young adults with PWS.

Design
Open-label, a prospective study in 43 young adults with PWS.

Methods
BMD of the total body (BMDTBSDS) and lumbar spine (BMADLSSDS) measured by DXA.

Results
In the total group, estimated mean (95% CI) of BMDTB remained similar during 3 years of GH, being −0.76 (−1.11 to −0.41) SDS at start and −0.90 (−1.27 to −0.54) SDS after 3 years (P = 0.11), as did BMADLS, being −0.36 (−0.72 to 0.01) SDS and −0.46 (−0.77 to −0.16) SDS, respectively (P = 0.16). In men, there was a significant decrease in BMDTBSDS during 3 years of GH, while BMADLSSDS remained similar. In women, both BMDTBSDS and BMADLSSDS remained similar. BMDTBSDS was associated with female sex, lean body mass and age. The majority of patients received sex steroid replacement therapy (SSRT).

Conclusions
During 3 years of combined GH and SSRT treatment, BMD remained stable in the normal range in young adults with PWS. However, men showed a decline in BMDTBSDS, probably due to insufficient SSRT. We recommended to continue GH treatment in young adults with PWS and to start SSRT during adolescence unless puberty progresses normally.
The Structural Analysis of Medicinal Plants and Their Use to Treat the Gastrointestinal Tract Diseases
Authors: Makhovska Liubov , Gniezdilova Victoria , Nespliak Oksana , Buniak Vira 
Published: March 2021

Medicinal plants have long been used in the treatment of various diseases and diseases of the digestive system, in particular. They contain almost all biologically active substances, which gives them an advantage over synthetic drugs, and the possibility of long-term use. On the basis of processing of literature sources the systematical and biomorphological analyzes of herbs were carried out. We analyzed the medicinal plants which are used to treat diseases of the gastrointestinal tract, including four groups: stomach (atony, achillia, ulcer, gastritis), intestine (enteritis, colitis), liver and gallbladder (hepatitis A, cholangitis, cholecystitis, nausea) and dyspeptic disorders (vomiting, constipation, diarrhea, bloating). Each of these groups of illnesses is characterized by a specific list of medicinal plants with an indication of their life form. 110 species of medicinal plants were identified, which belong to 102 genera, 46 families, 33 orders, 4 classes and 3 divisions. Among studied herbs, the most numerous are herbaceous polycarpics - 60 species (54.55%), while annuals have 21 species (19.01%), trees - 9 species (8.18%), shrubs - 8 species (7.27%), biennials - 7 species (6.36%), semi-shrubs - 4 species (3.64%) and lianas - 1 species (0.91%). The taxonomic and biomorphological structure of the studied plants is presented in general and analyzed in detail in each of the selected groups of diseases. Examples of plants that used in the treatment of various diseases of the gastrointestinal tract are given. It was established that for intestinal disease 28 species are used, liver and gallbladder - 47 species, stomach - 60 species and dyspeptic disorders - 75 species of herbs.
The article shows the results of taxonomic and biomorphologic analysis of medicinal plants that are used to treat the gastrointestinal tract diseases are based on literary data.
An Annotated List of the Lichens and Lichenicolous Fungi of the Teteriv River Basin (Ukraine)
Authors: Kapets Nadiia 
Published: March 2021

First data on lichens of the Teteriv River Basin appeared in the second part of 19th century. First records of lichenicolous fungi in this area were published at the end of the 20th century. An annotated list of lichens and lichenophilous fungi is based on literature data and materials of own researche of lichenobiota of the upper and middle course of the Teteriv river basin. Llist of lichens and lichenicolous fungi of the area includes 300 species. The distribution of 117 species (80 lichens, 37 lichenicolous fungi) are for the first time recorded for area studied. Five species (Cercidospora macrospora, Lichenostigma epipolina, Lichenothelia tenuissima, Polysporina subfuscescens і Taeniolella beschiana) are new to Ukraine, 7 species (Anisomeridium polypori, Coenogonium pineti, Lichenoconium usneae, Monodictys epilepraria, Rinodina efflorescens, Sphaerellothecium propinquellum, Taeniolella punctata) are new for the Ukrainian Plains, while 11 species (Cornutispora lichenicola, Erythricium aurantiacum, Heterocephalacria physciacearum, Intralichen christiansenii, Laetisaria lichenicola, Lichenothelia convexa, Marchandiomyces corallinus, Psoroglaena dictyospora, Pyrenochaeta xanthoriae, Sarcogyne lapponica, Scoliciosporum gallurae, Stigmidium xanthoparmeliarum) are new for the Polissia subprovince of mixed coniferous and broad-leaved forests, and one species is new for the territory of the Ukrainian forest-steppe subprovince. In addition, new information on the distribution of a number of rare to Ukraine lichen and lichenicolous fungal species (Absconditella lignicola, Cornutispora lichenicola, Clypeococcum hypocenomycis, Lichenochora obscuroides, Lichenodiplis lecanorae, Marchandiomyces corallinus, Psoroglaena dictyospora, Sclerococcum sphaerale, Strangospora deplanata, Thelocarpon epibolum ect.) is obtained.
Differentiating sepsis from similar groups of symptoms at triage level in emergency care
Authors: Molnár G. , Gyarmathy V. A. , Takács J. , Sándor S. , Kiss B. , Fazakas J. , Kanizsai P. L. 
Published: March 2021

AbstractObjectivesConditions that have similar initial presentations as sepsis may make early recognition of sepsis in an emergency room (ER) difficult. We investigated whether selected physiologic and metabolic parameters can be reliably used in the emergency department to differentiate sepsis from other disease states that mimic it, such as dehydration and stroke.MethodsLoess regression on retrospective follow-up chart data of patients with sepsis-like symptoms (N = 664) aged 18+ in a large ER in Hungary was used to visualize/identify cutoff points for sepsis risk. A multivariate logistic regression model based on standard triage data was constructed with its corresponding receiver operating characteristic (ROC) curve and compared with another model constructed based on current sepsis guidelines.ResultsAge, bicarbonate, HR, lactate, pH, and body temperature had U, V, W, or reverse U-shaped associations with identifiable inflexion points, but the cutoff values we identified were slightly different from guideline cutoff values. In contrast to the guidelines, no inflexion points could be observed for the association of sepsis with SBP, DPB, MAP, and RR and therefore were treated as continuous variables. Compared to the guidelines-based model, the triage data-driven final model contained additional variables (age, pH, bicarbonate) and did not include lactate. The data-driven model identified about 85% of sepsis cases correctly, while the guidelines-based model identified only about 70% of sepsis cases correctly.ConclusionOur findings contribute to the growing body of evidence for the necessity of finding improved tools to identify sepsis at early time points, such as in the ER.
Hydrodynamic assessment of combined sewerage overflow chamber in Banská Bystrica
Authors: Šutúš Marek , Hrudka Jaroslav , Rózsa Gergély , Škultétyová Ivona , Stanko Štefan 
Published: March 2021

AbstractThis research deals with creating a hydrodynamic combined sewerage overflow chamber model an ANSYS Workbench 19.2, Fluid Flow (Fluent). The 3D graphics model was created in the SpaceClaim modeling software, which serves as the basis for hydrodynamic modeling. The model was created according to a real combined sewerage overflow chamber in Banská Bystrica. The cores of the work are simulations that should correspond to the estimated flow in the combined sewerage overflow chamber. The aim of this paper is to compare the impact of inflow speed and flow rakes.
Modernization imposed: SOM’s practice in China – A case study of Wuhan
Authors: Tu Kangwei , Reith Andras 
Published: March 2021

AbstractSkidmore, Owings & Merrill Limited Liability Partnership as one of the best ‘localized’ overseas design companies in China, has participated in more than ten large-scale urban design projects in Wuhan, which has greatly changed the urban image and architectural style of Wuhan. Its space model of ‘grid road system + high-rise building’ replaces the traditional urban pattern of ‘street + residence’, causing huge cultural conflicts and historical rupture. Based on the planning of Wuhan Hanzheng street as an example, this paper attempts to uncover the cause of formation, the motivation mechanism of ‘grid road system + high-rise buildings’ space model, and to explore how Chinese cities realize the urban modernization with Chinese characteristics.