bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suicide reattempt in a population-wide brief contact intervention to prevent suicide attempts: The VigilanS program, France
Authors: Fossi Larissa D. , Debien Christophe , Demarty Anne-Laure , Vaiva Guillaume , Messiah Antoine 
Published: July 2021

Abstract

Objective
Among the postcrisis suicide prevention programmes, brief contact interventions (BCIs) have been proven to be efficient. VigilanS generalizes to a whole French region a BCI combining resource cards, telephone calls, and sending postcards, according to a predefined algorithm. However, a major problem in suicide prevention is the suicide reattempt, which can lead to final suicide. Here, we analyze the suicide reattempt in VigilanS.

Methods
The study concerned patients included in VigilanS over the period from January 1, 2015 to December 31, 2018, with an end of follow-up on July 1, 2019. We performed a series of descriptive analyses, survival curves, and regressions. The outcome was the suicide reattempt, and the predictive variables were the characteristics of the patient at entry and during follow-up in VigilanS. Age and sex were considered as adjustment variables.

Results
A total of 11,879 inclusions occurred during the study period, corresponding to 10,666 different patients, among which 905 reattempted suicide. More than half were primary suicide attempters (53.4%). A significant relationship with suicide reattempt was identified for the following characteristics: being a non-primary suicide attempter, having attempted suicide by voluntary drug intoxication and phlebotomy, alcohol consumption among primary suicide attempters, and having no companion at the emergency room visit among non-primary suicide attempters. Hanging (as suicide method), having made no call to VigilanS were protective factors.

Conclusion
This study provides us with a valuable insight into the profiles of patients repeating a suicide attempts, which is important for suicide prevention in general.
H4K20me3 marks distal intergenic and repetitive regions in human mature spermatozoa
Authors: Ozturk Nihan , Dansranjavin Temuujin , Gies Sabrina , Calay Damien , Shiplu Shanjid , Creppe Catherine , Hendrickx Jan , Schagdarsurengin Undraga 
Published: July 2021

ABSTRACT
Sperm histones represent an essential part of the paternally transmitted epigenome, but uncertainty exists about the role of those remaining in non-coding and repetitive DNA. We therefore analyzed the genome-wide distribution of the heterochromatic marker H4K20me3 in human sperm and somatic (K562) cells. To specify the function of sperm histones, we compared all H4K20me3-containing and -free loci in the sperm genome. Sperm and somatic cells possessed a very similar H4K20me3 distribution: H4K20me3 peaks occurred mostly in distal intergenic regions and repetitive gene clusters (in particular genes encoding odorant-binding factors and zinc-finger antiviral proteins). In both cell types, H4K20me3 peaks were enriched in LINEs, ERVs, satellite DNA and low complexity repeats. In contrast, H4K20me3-free nucleosomes occurred more frequently in genic regions (in particular promoters, exons, 5′-UTR and 3′-UTR) and were enriched in genes encoding developmental factors (in particular transcription activators and repressors). H4K20me3-free nucleosomes were also detected in substantial quantities in distal intergenic regions and were enriched in SINEs. Thus, evidence suggests that paternally transmitted histones may have a dual purpose: maintenance and regulation of heterochromatin and guidance towards transcription of euchromatin.
Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features
Authors: Rayon Teresa , Maizels Rory J. , Barrington Christopher , Briscoe James 
Published: July 2021

ABSTRACT
The spinal cord receives input from peripheral sensory neurons and controls motor output by regulating muscle innervating motor neurons. These functions are carried out by neural circuits comprising molecularly distinct neuronal subtypes generated in a characteristic spatiotemporal arrangement from progenitors in the embryonic neural tube. To gain insight into the diversity and complexity of cells in the developing human neural tube, we used single-cell mRNA sequencing to profile cervical and thoracic regions in four human embryos of Carnegie stages (CS) CS12, CS14, CS17 and CS19 from gestational weeks 4-7. Analysis of progenitor and neuronal populations from the neural tube and dorsal root ganglia identified dozens of distinct cell types and facilitated the reconstruction of the differentiation pathways of specific neuronal subtypes. Comparison with mouse revealed overall similarity of mammalian neural tube development while highlighting some human-specific features. These data provide a catalogue of gene expression and cell type identity in the human neural tube that will support future studies of sensory and motor control systems. The data can be explored at https://shiny.crick.ac.uk/scviewer/neuraltube/.
Ultrahigh sensitive long-period fiber grating-based sensor for detection of adulterators in biofuel
Authors: Dandapat Krishnendu , Kumar Indrajeet , Tripathi Saurabh Mani 
Published: July 2021

An ultra-sensitive sensor based on dual resonance long-period fiber gratings has been fabricated for the detection of methanol and water content in ethanol. The developed sensor is compact in size and light weight and employs a highly accurate spectral interrogation technique for adulterant detection, increasing its applicability compared to conventional surface plasmon resonance based sensors, which are generally expensive, as they require metal film deposition. We demonstrate that the sensor is capable of achieving sensitivity of 802.66 pm/V% methanol and 749.06 pm/V% water in the ethanol solution. The estimated detection limit using the experimental data and spectral resolution of the interrogator is found to be

∼

1.3
×

10

−
3

V

%

in the 1300–1700 nm wavelength range. We also present the sensor’s theoretical study, and good agreement is found between theoretical and experimental results.
Compact scanning confocal chromatic sensor enabling precision 3-D measurements
Authors: Wertjanz Daniel , Kern Thomas , Csencsics Ernst , Stadler Gerhard , Schitter Georg 
Published: July 2021

This paper proposes a compact and lightweight scanning confocal chromatic sensor (SCCS) for robot-based precision three-dimensional (3-D) surface measurement applications. The integrated system design includes a 2-D fast steering mirror (FSM) to manipulate the optical path of a high precision 1-D confocal chromatic sensor (CCS). A data-driven calibration procedure is used to accurately combine the FSM deflection angles and the correspondingly measured distances to the sample surface in order to obtain a correctly reconstructed 3-D image. Lissajous scan trajectories are applied to enable efficient scans of the sample surface. The SCCS provides 3-D images at frame rates of up to 1 fps and a measurement volume of

0.35
×
0.25
×
1.8

m
m

3

, as well as the measurement of arbitrary regions of interest. Using a calibration standard including structures with defined sizes, the lateral and axial resolutions are determined to 2.5 µm and 76 nm, respectively.
Quantitative blood flow estimation in vivo by optical speckle image velocimetry
Authors: Qureshi Muhammad Mohsin , Liu Yan , Mac Khuong Duy , Kim Minsung , Safi Abdul Mohaimen , Chung Euiheon 
Published: July 2021

Speckle-based methods are popular non-invasive, label-free full-field optical techniques for imaging blood flow maps at single vessel resolution with a high temporal resolution. However, conventional speckle approaches cannot provide an absolute velocity map with magnitude and direction. Here, we report an optical speckle image velocimetry (OSIV) technique for measuring the quantitative blood flow vector map by utilizing particle image velocimetry with speckle cross-correlations. We demonstrate that our OSIV instrument has a linearity range up to 7 mm/s, higher than conventional optical methods. Our method can measure the absolute flow vector map at up to 190 Hz without sacrificing image size, and it eliminates the need for a high-speed camera/detector. We applied OSIV to image the blood flow in a mouse brain, and as a proof of concept, imaged real-time dynamic changes in the cortical blood flow field during the stroke process in vivo. Our wide-field quantitative flow measurement OSIV method without the need of tracers provides a valuable tool for studying the healthy and diseased brain.
One hundred years of zoonoses research in the Horn of Africa: A scoping review
Authors: Cavalerie Lisa , Wardeh Maya , Lebrasseur Ophélie , Nanyingi Mark , McIntyre K. Marie , Kaba Mirgissa , Asrat Daniel , Christley Robert , Pinchbeck Gina , Baylis Matthew , Mor Siobhan M. 
Published: July 2021

BackgroundOne Health is particularly relevant to the Horn of Africa where many people’s livelihoods are highly dependent on livestock and their shared environment. In this context, zoonoses may have a dramatic impact on both human and animal health, but also on country economies. This scoping review aimed to characterise and evaluate the nature of zoonotic disease research in the Horn region. Specifically, it addressed the following questions: (i) what specific zoonotic diseases have been prioritised for research, (ii) what data have been reported (human, animal or environment), (iii) what methods have been applied, and (iv) who has been doing the research?Methodology/principal findingsWe used keyword combinations to search online databases for peer-reviewed papers and theses. Screening and data extraction (disease, country, domain and method) was performed using DistillerSR. A total of 2055 studies focusing on seven countries and over 60 zoonoses were included. Brucellosis attracted the highest attention in terms of research while anthrax, Q fever and leptospirosis have been comparatively under-studied. Research efforts did not always align with zoonoses priorities identified at national levels. Despite zoonoses being a clear target for ‘One Health’ research, a very limited proportion of studies report data on the three domains of human, animal and environment. Descriptive and observational epidemiological studies were dominant and only a low proportion of publications were multidisciplinary. Finally, we found that a minority of international collaborations were between Global South countries with a high proportion of authors having affiliations from outside the Horn of Africa.Conclusions/significanceThere is a growing interest in zoonoses research in the Horn of Africa. Recommendations arising from this scoping review include: (i) ensuring zoonoses research aligns with national and global research agendas; (ii) encouraging researchers to adopt a holistic, transdisciplinary One Health approach following high quality reporting standards (COHERE, PRISMA, etc.); and (iii) empowering local researchers supported by regional and international partnerships to engage in zoonoses research.
Severe undernutrition in children affects tuberculin skin test performance in Southern India
Authors: Reddy Divya , Ma Yicheng , Lakshminarayanan Subitha , Sahu Swaroop , White Laura F. , Reshma Ayiraveetil , Roy Gautam , Salgame Padmini , Knudsen Selby , Cintron Chelsie , Ellner Jerrold J. , Horsburgh C. Robert , Sarkar Sonali , Hochberg Natasha S. 
Published: July 2021

Background
Undernutrition impairs immunity to Mycobacterium tuberculosis and is a risk factor for tuberculosis disease (TB). We aim to investigate if severe undernutrition affects the tuberculin skin test (TST) response among household contacts (HHCs) of pulmonary TB cases.

Methods
We analyzed data from HHCs (> five years) of pulmonary TB cases in Southern India. Undernutrition was defined as per World Health Organization based on body mass index (BMI) for adults (undernutrition 16–18.4 and severe undernutrition <16 kg/m2) and BMI relative to the mean for children (undernutrition 2SD-3SD and severe undernutrition < 3SDs below mean). Univariate and multivariate models of TST positivity (> five mm) were calculated using logistic regression with generalized estimating equations.

Results
Among 1189 HHCs, 342 were children (age 5–17 years) and 847 were adults. Prevalence of TST positivity in well-nourished, undernourished and severely undernourished children was 135/251 (53.8%), 32/68 (47.1%), and 7/23 (30.4%) respectively; among adults, prevalence of TST positivity was 304/708 (42.9%), 43/112 (38.4%) and 12/26 (46.2%), respectively. Severe undernutrition in children was associated with decreased odds of TST positivity (adjusted odds ratio 0.3; 95%CI 0.1–0.9).

Conclusion
Severe undernutrition in children was associated with decreased odds of TST positivity. False-negative TSTs may result from undernutrition; caution is warranted when interpreting negative results in undernourished populations.
Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder
Authors: Han Xueyan , Liu Xinxin , Zhong Fengxing , Wang Yiguo , Zhang Qiming 
Published: July 2021

Background
Essential hypertension (EH) with anxiety or depression belongs to the category of psycho-cardiology. Hypertension is closely related to anxiety and depression. The adverse reactions of Western medicine are apparent and the compliance is poor. Supplementary and replacement therapies have accumulated rich experience in clinical practices, which can reduce side effects and improve clinical efficacy. This study intends to use the Bayesian network meta-analysis (NMA) analysis method for the first time to gather randomized controlled trials (RCTs) related to complementary and alternative therapies in the treatment of hypertension with anxiety or depression disorder and rank efficacy and safety, to provide a reference basis for the treatment of hypertension with anxiety or depression disorder.

Methods
All randomized controlled trials (RCTs) and registered and ongoing trials of Chinese and English databases, related to supplementation and replacement therapies of EH with anxiety or depression disorder, published from initial state to February 2021, will be collected in the form of computer retrieval. Two researchers will independently screen the literature, extracting data, assessing bias risk and assessing heterogeneity. We will use software WinBUGS 1.4.3 and Stata 16.0 for pairwise meta-analysis and NMA to comprehensively evaluate various interventions. The quality of evidence will be evaluated through the Grading of Recommendations Assessment, Development and Evaluation (GRADE).

Results
This NMA will comprehensively compare and rank the efficacy and safety of a series of complementary and alternative therapies in treating EH with anxiety or depression disorder.

Conclusion
Supplementary and replacement therapies have accumulated rich experience of clinical practices in improving EH with anxiety or depression disorder. We expect that this NMA will guide practice and research by providing reliable evidence of evidence-based medicine for the treatment of EH with anxiety or depression disorder.

Protocol registration number
INPLASY202120068.
Existence and concentration of positive solutions for a critical p&q equation
Authors: Costa Gustavo S. , Figueiredo Giovany M. 
Published: July 2021

Abstract
We show existence and concentration results for a class of p&q critical problems given by

−
d
i
v

a

ϵ

p

|

∇
u

|

p

ϵ

p

|

∇
u

|

p
−
2

∇
u

+
V
(
z
)
b

|

u

|

p

|

u

|

p
−
2

u
=
f
(
u
)
+

|

u

|

q

⋆

−
2

u

in

R

N

,

$$-div\left(a\left(\epsilon^{p}|\nabla u|^{p}\right) \epsilon^{p}|\nabla u|^{p-2} \nabla u\right)+V(z) b\left(|u|^{p}\right)|u|^{p-2} u=f(u)+|u|^{q^{\star}-2} u\, \text{in} \,\mathbb{R}^{N},$$

where u ∈ W
1,p
(ℝ
N
) ∩ W
1,q
(ℝ
N
), ϵ > 0 is a small parameter, 1 < p ≤ q < N, N ≥ 2 and q
* = Nq/(N − q). The potential V is positive and f is a superlinear function of C
1 class. We use Mountain Pass Theorem and the penalization arguments introduced by Del Pino & Felmer’s associated to Lions’ Concentration and Compactness Principle in order to overcome the lack of compactness.
Association of muscle mass and fat mass on low-density-lipoprotein cholesterol and triglyceride plasma concentration in children and adolescents
Authors: Martakis Kyriakos , Stark Christina , Rehberg Mirko , Jackels Miriam , Schoenau Eckhard , Duran Ibrahim 
Published: July 2021

Abstract

Objectives
Obesity has often been associated with high low-density-lipoprotein cholesterol (LDL-C) and triglyceride plasma concentrations, known risk factors for diabetes mellitus and cardiovascular disease. Study objective was to evaluate the association of LDL-C and triglyceride plasma concentration with muscle and fat mass in children and adolescents.

Methods
We analyzed data of the National Health and Nutrition Examination Survey (1999–2004) to estimate lean muscle and fat mass assessed by dual-energy X-ray absorptiometry (DXA) of participants whose lipid profiles had been examined. Fat mass was operationalized by DXA-determined fat mass index (FMI). Muscle mass was assessed by appendicular lean mass index (aLMI). High LDL-C and triglyceride concentration was defined as above 130 mg/dL.

Results
For the evaluation of the association of LDL-C and triglyceride plasma concentration with LMI and FMI Z-scores, the data of 2,487 children and adolescents (age 8–19 years) (984 females) were eligible. High aLMI showed no association with LDL-C or triglyceride concentration, but high FMI showed significant association with LDL-C and triglyceride plasma concentration in the bivariate regression analysis.

Conclusions
Isolated muscle mass increase may not be protective against high LDL-C and triglycerides plasma levels in children and adolescents. Thus, exercise may lead to risk factor reduction mainly through fat mass reduction.
Crystal structure of catena-poly[diaqua-bis(μ2-1,3-di(1H-imidazol-1-yl)propane-κ2
N:N′)cobalt(II)] dinitrate, C18H28N10O8Co
Authors: Liu Jie , Jiang Peng , Yang Xiao-Ming , Lu Jiu-Fu 
Published: July 2021

Abstract
C18H28N10O8Co, monoclinic, P21/c (no. 14), a = 9.2248(5) Å, b = 13.3140(8) Å, c = 10.6132(6) Å, β = 109.348(7)°, V = 1229.89(13) Å3, Z = 2, R

gt
(F) = 0.0336, wR

ref
(F
2) = 0.1078, T = 293(2) K.
Bildung im Anthropozän
Authors: Wulf Christoph 
Published: July 2021

AbstractDer Beitrag untersucht, welche Rolle Glaubenssysteme im Anthropozän spielen. Behandelt wird einmal das Glaubenssystem, auf dessen Grundlage alle Fakten und Argumente so organisiert und interpretiert werden, dass sie dazu beitragen, die negativen Auswirkungen des Anthropozäns zurückzuweisen. Der Schwerpunkt des Artikels liegt jedoch auf den Glaubenssystemen, in deren Rahmen umfangreiche Forschungen nachweisen, dass große Teile der Menschheit für die Fehlentwicklungen im Anthropozän verantwortlich sind. Eine „dunkelgrüne Religion“ beeinflusst die Wahrnehmung, Untersuchung und Interpretation der Natur und begründet die Kritik an den negativen Entwicklungen unter Bezug auf religiöse Glaubens- und Referenzsysteme. Sodann werden sakralen Formen der Kritik beschrieben, wie sie z.B. in der Bewegung „Fridays for Future“ sichtbar werden. Deutlich wird dabei, dass grundlegende Veränderungen gesellschaftlichen Verhaltens in Glaubenssystemen verankert sein müssen, um die intendierte Wirksamkeit zu entfalten.
Forebrain Neural Precursor Cells Are Differentially Vulnerable to Zika Virus Infection
Authors: Shelton Samantha M. , Soucy Alexandra R. , Kurzion Ronni , Zeldich Ella , Connor John H. , Haydar Tarik F. 
Published: July 2021

AbstractPrenatal exposure to Zika virus (ZIKV) can result in microencephaly and congenital Zika syndrome, although some brain cells and structures are spared by the virus for unknown reasons. Here, a novel murine model of fetal ZIKV infection incorporating intraventricular infection and cell type-specificin uteroelectroporation (IUE) was used to identify the time course of ZIKV infection and to determine the identity of cells that are initially infected or spared during neocortical neurogenesis.In vivotime course studies revealed the presence of ZIKV in apical radial glial cells (aRGCs) at early time points following virus exposure, while basal intermediate progenitor cells (bIPCs) became maximally (ZIKV+) after 3 d of virus exposure. ZIKV-infected fetal brains exhibited microencephaly as early as 1 d following infection, regardless of developmental age. This change in brain size was caused in part by apoptosis and reduced proliferation that persisted until birth. While 60% of aRGC basal fibers were perturbed during infection, 40% retained normal morphology, indicating that aRGCs are not uniformly vulnerable to ZIKV infection. To investigate this heterogeneous vulnerability, we performed genetic fate mapping using cell type-specific probes derived from a mouse embryonic day (E)15.5 neocortical wall single-cell RNA sequencing (scRNAseq) dataset. The results indicate that one class of aRGCs preferentially express the putative ZIKV entry receptorAXLand that these cells are more vulnerable to ZIKV infection than other aRGC subtypes with lowAXLexpression. Together, these data uncover crucial temporal and cellular details of ZIKV fetal brain infection for prevention strategies and for management of congenital Zika syndrome.
Impact of obesity on echocardiographic parameters and N-terminal pro-brain natriuretic peptide levels in patients with heart failure with mid-range ejection fraction: unanswered questions
Authors: Lyasnikova E. A. , Kuular A. A. , Pavlovskaya A. V. , Vlasenko A. N. , Kozlenok A. V. , Babenko A. Yu. , Sitnikova M. Yu. , Shlyakhto E. V. 
Published: July 2021

Aim. To analyze and compare the clinical, echocardiographic characteristics and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels depending on the central cardiometabolic risk factors, with a focus on obesity, in patients with heart failure (HF) with mid-range ejection fraction (HFmrEF).Material and methods. The study included 111 patients with old myocardial infarction and HFmrEF (men, 100%; mean age, 60 years) predominantly of NYHA class II. Echocardiography and blood sampling for NT-proBNP were performed with sinus rhythm. Left atrial volume (LAV) and left ventricular mass (LVM) were indexed to body surface area (BSA) and height raised to a power.Results. Type 2 diabetes, overweight and obesity were diagnosed in 25%, 19%, 38% of cases, respectively, and were associated with greater changes in the morphologic and functional left ventricular parameters. There were no intergroup differences among patients with and without obesity in the LAV and LVM indexed to BSA. However, in patients with a body mass index (BMI) ≥30 kg/m2, the LAV indexed to height squared and LVM indexed to height2,7 were higher (p<0,05 for all). In 11% of obese patients, there were no changes in the criterion LAV or LVM values indexed to BSA, but the values indexed to height raised to a power exceeded the standard values. In 20% of patients with clinical manifestations of stable HFmrEF and structural and functional echocardiographic criteria, NT-proBNP were ≤125 pg/ml. An inverse correlation was found between NT-proBNP and BMI (r=-0,29; p=0,008), and lower values of myocardial stress marker were observed in obese patients (p=0,048).Conclusion. Considering the high incidence of obesity in patients with HFmrEF and its ability to reduce NT-proBNP, an algorithm modification is required for diagnosing HFmrEF as follows: focus on clinical and personalized echocardiography data, taking into account the obesity and, possibly, indexing the threshold natriuretic peptide values in patients with BMI ≥30 kg/m2. The issues of indexation of echocardiographic parameters depending on morphometric parameters in obese patients today remain open, predetermining the limitations in diagnosis of heart failure with left ventricular ejection fraction >40%. This requires the search for optimal standardization and the development of a unified methodological approach.