bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online Dispute Resolution e Inteligência Artificial: a influência tecnológica na resolução de conflitos.
Authors: Siqueira Oniye Nashara , Zanferdini Flávia de Almeida Montingelli 
Published: July 2021

O desenvolvimento tecnológico e a expansão da conectividade modificaram as relações sociais e, consequentemente, os modos e meios de resolução de conflitos, apontando, sendo a Resolução Online de Conflitos (Online Dispute Resolution - ODR) uma via em ascensão, complementar ao Judiciário, cuja crise é manifesta. Diante disso, o presente estudo analisa como a tecnologia, aliada à incomensurável quantidade de informações contidas no ciberespaço, propiciou a criação de um nicho inovador, capaz de apontar dados estatísticos e predizer resultados. Esta nova realidade, caracterizada pelo tratamento de dados, é capaz de criar perfis e, diante disso, facilitar a composição de litígios por meio da condução comportamental dos envolvidos o que, por outro lado, pode violar direitos fundamentais dos litigantes, como o de privacidade. Assim, analisamos como a crise do judiciário contribuiu para a popularização dos meios complementares ou alternativos de resolução de demandas (ADR), para então apontarmos a mudança dos paradigmas resultante do uso das Tecnologias da Informação e Comunicação (TICs) na resolução de litígios. Após, discorremos sobre como a utilização da inteligência artificial é capaz de conduzir à resolução do conflito, concluindo que esta nova realidade traz benefícios aos cidadãos, contudo, com a ressalva da necessária proteção dos dados e preservação da privacidade digital. Aplicamos o método de abor­dagem dedutivo, em conjunto com a pesquisa doutrinária.
CFIT PREVENTION WITH COMBINED ENHANCED FLIGHT VISION SYSTEM AND SYNTHETIC VISION SYSTEM
Authors: Iradukunda Klarisse , Averyanova Yuliya 
Published: July 2021

This paper aims to combine two vision systems as a new technology to suggest the improvement in the continuing problem of Controlled Flight into Terrain (CFIT) accidents. A combined enhanced flight vision system and synthetic vision system seems to hold the solution, while it unhesitatingly accommodated to the commercial and General aviation instrument environment if pilots are getting minimal instrument training. This research shows the benefit of combined enhanced flight vision and synthetic vision systems based on analysis of the accident that occurred in 2013 on approach at Birmingham-Shuttlesworth International Airport. It is shown that the use of a combined system, could have prevented this accident. The head-up display is taken to facilitate this technology to the pilot to be able to see and read accurately using sky lenses.
Lotus flower model: With metaphorical perceptions of the chemistry of daily life
Authors: Altundaay Canan Kocak 
Published: July 2021

This study aimed to determine teacher candidates’ perception about ‘chemistry’ through metaphors. In this study, 60 teacher candidates training at different programmes of Hacettepe University, Faculty of Education, participated. The metaphors of teacher candidates about chemistry were collected through a diagram prepared according to the Lotus Flower Technique. After the 3,754 metaphors were defined and 8 imaginary categories to represent these metaphors were developed, the number of metaphors and its percentage were calculated for each category. As a result, it appears that, the images of the teacher candidates regarding the metaphorical perceptions of the chemistry of daily life and general chemistry are significantly different from each other. Metaphors are able to change conceptual systems and the perspectives of individuals towards the world. Therefore, this study catered to the introduction of metaphorical images, which bring new perspectives to teacher candidates about the chemistry of daily life.

Keywords: Lotus flower, model, metaphors, daily life, chemistry.
PHARMACOKINETIC PROPERTIES OF A NEW KAPPA-OPIOID ANALGESIC RU-1205 COMPOUND AT A SINGLE PERORAL ADMINISTRATION
Authors: Spasov A. A. , Smirnova L. A. , Grechko O. Yu. , Eliseeva N. V. , Lifanova Yu. V. , Rashchenko A. I. , Zhukovskaya O. N. , Morkovnik A. S. , Anisimova V. A. 
Published: July 2021

The aim of the study is the investigation of the pharmacokinetic properties of the RU-1205 compound, with previously identified kappa-agonistic and analgesic effects, at a single oral administration, as well as comparison of the relationship between its pharmacokinetic and analgesic properties.Materials and methods. Pharmacokinetic parameters of RU-1205 after the oral administration at the dose of 50 mg / kg were investigated using the method of High Performance Liquid Chromatography with determination of the concentration of the compound according to the previously constructed calibration schedule. The indices of the area under the pharmacokinetic curve, clearance, half-life, residence time of the drug molecule in the body, a total (apparent) volume of distribution, as well as the indicator of absolute bioavailability, were calculated. The tissue distribution and excretion of RU-1205 were studied.Potential metabolites of RU-1205 were predicted using the PALLAS 3.00 program. The study of the analgesic activity was carried out on a model of central somatogenic pain with electricalstimulation, with the dynamics assessment of the voltage amplitude of the corresponding reaction of the "tail-flick" reflex.Results. The compound under study is rapidly adsorbed from the gastrointestinal tract, reaching a maximum concentration by the end of the first hour of the study, and is determined in plasma within 12 hours. Its half-life is 17.7 hours. The absolute oral bioavailability is 37.3%. It was found out that the compound is withdrawn within 3-4 days. The main route of excretion is extrarenal. Biotransformation of a substance probably proceeds mainly with the formation of oxidized forms of the initial molecule by reactions of the first phase of metabolic transformation. The analgesic effect is long-lasting: it starts after 15 minutes and lasts for 12 hours with flattening of the curve by the 8th hour.Conclusion. When administered orally, the test substance undergoes a long process of elimination, has the greatest tropism for the elimination organs and undergoes active biotransformation processes in the body of animals. As a result of it, active metabolic products with an analgesic activity are, possibly, formed.
The Protection of Indonesian Migrant Workers under Fiqh Siyasah Dusturiyah
Authors: Ismail Habib , Hakim Dani Amran , Hakim Muhammad Lutfi 
Published: July 2021

The position of migrant workers is often seen as a weak party. To some extent, such migrant workers are regarded as similar to slaves. In Indonesia, the government has to protect all citizens, including those abroad who have the status of migrant workers. Migrant Workers’ Protection Law 18/2017 was issued to protect citizens as migrant workers. However, several migrant workers remained legally unprotected abroad. This study used the normative approach that aimed to discuss the protection of Indonesian migrant workers from two-fold, juridical and fiqh siyasah dusturiyah perspectives. While the government protected migrant workers by issuing Law 18/2017, it has more specifically provided directions and objectives to protect migrant workers. This Law ensures human rights for migrant workers despite legal, economic, and social protection for them and their families. Then, the protection of migrant workers from fiqh siyasah dusturiyah should be under the four principles of the workforce in Islam: human independence, human dignity, justice, and the clarity of the contract and wage transaction.
KEYWORDS: Indonesian Migrant Workers, Right to Work, Islamic Law.
Seismogravimetric Methodology: Specifics and Applicability to the Siberian Platform
Authors: Kochnev V.A. 
Published: July 2021

Abstract
—The paper presents a new seismogravimetric method for estimating static corrections used in processing of seismic data and in construction of time and depth sections. The method efficiency is demonstrated by comparison of the results of industrial and new experimental processing of data for the western slope of the Nepa–Botuoba anteclise.
Error Control Mechanism Based on Reed-Solomon Code for Wireless Networks
Authors: Wang Xinyu , Shi Kai , Wang Jinsong , Lin Sheng , Xu Guangping , Qiao Fuqiang 
Published: July 2021

Abstract
The reliability of information transmission has a significant influence on network performance, so it has attracted extensive attention from researchers. Many error control mechanisms have been designed and proposed in order to improve the reliability of transmission. However, during transmission in wireless networks, high bit error rate and burst errors often occur, which poses great challenges in the design of error control mechanisms. The existing mechanisms suffer from a problem of either poor error correction ability or waste of network resources. The primary aim of this study is to develop an error control mechanism based on Reed-Solomon (RS) codes, which encodes packets using RS codes, and a re-encoding algorithm is designed for reducing the coded packet length. The proposed error control mechanism can not only reduce the number of redundant bits in the transmission process but also improve the error correction ability as much as possible when burst errors occur. Therefore, both the error correction ability and the network utility are considered in this work. The proposed mechanism was verified through theoretic analysis and by experiments using the NS2 simulator. The experimental results verified the error control ability and throughput performance of the proposed mechanism.
A highly efficient cloth facemask
Authors: Cappa Christopher , Department The San Francisco Opera Costume , Ristenpart William , Barreda Santiago , Bouvier Nicole , Levintal Elad , Wexler Anthony , Roman Sanziana 
Published: July 2021

Abstract
Wearing masks and face coverings helps reduce transmission of respiratory diseases. Much prior research on mask filtration efficiency has focused on fabric type, with less consideration given to mask design and shape. Here, we present evidence that increasing the mouth-mask separation distance engenders an increase in the mask-fabric filtration efficiency towards expiratory aerosols emitted via vocalization, which we attribute to a decrease in the expiratory jet velocity and expansion of the breath-mask contact area. We further assess the performance of a new reusable cloth facemask design, originally made for, but not exclusive to, professional singers and having a large mouth-mask separation distance. With proper fitting, these masks achieve overall filtering efficiencies of >93% for both exhaled expiratory aerosols >0.5 microns in diameter from singing and speaking and for inhaled ambient aerosols, better than surgical masks and approaching N95 respirators. Air exchange between the mask deadspace and the ambient environment limits the extent of CO2 buildup and in inhaled air and maintains O2 levels near ambient. The mask design also provides for less inhibited mouth and jaw movement and lower relative humidity, suggesting it may provide a more palatable, high-efficiency alternative to medical-grade masks for the public.
The Effects of rural income project on silk exports and livelihood of smallholder producers in Gatsibo District, Rwanda.
Authors: Ogunlusi Abiola , Olaniyan Olanrewaju 
Published: July 2021

Abstract
Sericulture has been seen in Rwanda as an opportunity for increasing raw materials for the textile industry. Therefore, it has provided a new source of income, reduced unemployment and most likely to improve the livelihood status of poor sericulture smallholder producers by increasing their income earnings. The high yield in silk production has been pleasing due to the favourable climatic conditions for mulberry cultivation, sericulture has been seen as a potential tool to reduce poverty and also to generate foreign exchanges from exportation. The broad objective of this paper focuses on the impact of the livelihood status of smallholder producers in Rwanda. Purposive and simple random sampling techniques were employed in selecting 286 sericulture households’ farmers in Gatsibo district. Data for this study were analysed using descriptive statistics, inferential statistics, paired-samples t-test, cross-tabulation and chi-square test of independence. The results of this study showed clearly a significant improvement in the livelihood of the farmers. It was gathered that 82% asserted there are organized markets available for silk exportation. 77% affirmed an improvement in their income status. The average level of income per year from cocoon production among the farmers was estimated to be $227.59. It is of topmost priority for this program to continue because its effect has a very positive impact on the livelihood status of the beneficiaries. Farmers should be provided with continuous training, access to credits. If sustained properly it will resolve future challenges and springs more opportunities for farmers and likewise to the country through exports.
A tumor of composite cervical adenocarcinoma with MUCIN gene mutation：a case report
Authors: Guo Meijun , Li Guoping , Jiang Xiuxiu , Lv Shiming 
Published: July 2021

Abstract
Background : There are reports about the coexistence of two kinds of tumors in the same patient,which is believed that this phenomenon is caused by the dedifferentiation between the two tumors.In this paper, we report an human papillomavirus (HPV) negative cervical adenocarcinoma in a patient composed of two adenocarcinoma components,which is first reported.Histologically, both minimal deviation adenocarcinoma (MDA) and poorly differentiated gastric type adenocarcinoma (GTA) components, as well as their transitional area, were observed.Methods : This case of cervical cancer was screened by gene sequencing. For detection of specific somatic mutations in MDA and GTA, we filtered out mutations in malignant cervical cancer blood sample and 7 common cervical carcinoma. Then the genes were screened and identified based on the enrichment analysis of GO and KEGG and related literature reports. Results : We found 13 specific somatic gene mutations in total. Among these genes, only Mucin gene was transformed from gene level to protein level, and was positive in both MDA and GTA components of the patient by immunohistochemistry.Both components had genes mutation of MUC4 and MUC17,the component in MDA had gene mutation of MUC3A,and we found that MUC3A and MUC17 were on the same chromosome. Moreover,MUC3A and MUC4 genes were found to be fused in FusionGDB database. Conclusion : According to the reports of MUC3A,MUC4 and MUC17 genes mutation in cervical adenocarcinoma and gene fusions in tumorigenesis, we speculate that the occurrence of the transformation of pathological type from MDA to GTA in this case of cervical cancer is related to the mechanism of MUC3A and MUC4 gene fusion.We would advice, for HPV negative or atypical cervical lesions, immunohistochemistry of MUCIN genes staining and gene sequencing should be considered, which may find unusual cancer types and change the prognosis of patients.
Structure Based Screening Of Fungal Bioactive Metabolites As Potential Inhibitors Of Main Protease (Mpro) Of SARS-CoV-2
Authors: Saraf Ashish , Shrivastava Meghna , Shukla K K 
Published: July 2021

Abstract
The pandemic disease COVID-19 has put the world into a massive threat. Till now no effective treatment has been established and the world is applying lockdowns as a preventive measure against this. Recent studies have identified that COVID-19 main protease (Mpro) is essential for its life cycle and is responsible for the proteolytic mutation of this virus. Thus, destruction of the complete viral particle can be achieved through inhibition of this main protease. The fungal metabolites have already been proved as potential antimicrobial agents hence were selected for in-silico molecular docking, to check their affinity towards COVID-19 main protease. Metabolites like 2H-oxecin-3-one,3,4,7,8,9,10hexahydro-4-methoxy-10-methyl, Eicosanoic acid phenylmethyl ester, HEPES, 2,4-dihydroxy,2,5-dimethyl-furan(3)one and Dodecanoic acid-3-hydroxy have revealed strong binding affinity towards the main protease. Thus, the present study enlightens a path to combat COVID-19 by the use of bioactive metabolites.
Solitary Fibrous Tumor/Hemangiopericytoma of the Cervical Spine – A Case Report
Authors: suisa haggai , Ronen Galia , Eran Ayelet , Sviri Gil Ephraim , Vlodavsky Euvgeni 
Published: July 2021

Abstract
Introduction: Due to its rarity, the clinical and radiological characteristics of spinal solitary fibrous tumors/hemangiopericytomas remain largely unknown, with only 68 cases documented worldwide between 2000 and 2017. Case Presentation: We report a case of a 39-year-old female patient who presented to the emergency department with complaints of persisting headaches, a numbing sensation in both arms and a progressive loss of manual dexterity. Physical and neurological examinations were unremarkable. A cervical contrast-enhanced MRI revealed an intradural intramedullary space-occupying lesion at the C3 level, accompanied by extensive edema. The patient underwent a successful cervical laminoplasty under neurophysiological monitoring with en-bloc removal of the mass. She experienced total resolution of her symptoms. Biopsy revealed a grade I solitary fibrous tumor/hemangiopericytoma of the cervical spine, positive for CD34 and STAT6. Ki-67 index was 2%. Conclusion: This case report combines a rare tumor subtype with a unique presentation, and may further advance our understanding of this clinical entity.
The m6A demethylase FTO promotes esophageal cancer progression through YTHDF1-dependent posttranscriptional silencing of AKT3
Authors: Zang Chunbao , Zhao Fangfang , Huang Dabing , Kong Lingsuo , Xie Minghua , Tan Yiao , Pu Youguang 
Published: July 2021

Abstract
Background : N 6 -methyladenosine (m 6 A) is the most abundant modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in many bioprocesses. However, its functions in esophageal cancer remain elusive.
Methods : Methylated RNA immunoprecipitation sequencing (MeRIP-seq) and transcriptomic RNA sequencing (RNA-seq) were used to screen the target genes of FTO. Western blot, quantitative real-time PCR (RT-qPCR) and immunohistochemical (IHC) were used to detect FTO expression in cell lines and patient tissues. The biological functions of FTO were investigated in vitro and in vivo . RNA pull-down and RNA immunoprecipitation assays were conducted to explore the specific binding of target genes.
Results : We discovered that the RNA demethylase FTO was significantly up-regulated in esophageal cancer patients. Knockdown of FTO drastically reduced esophageal cancer cells (ESCCs) proliferation, migration, invasion, and apoptosis. On the other hand, overexpression of FTO significantly promoted ESCCs growth and invasion. Moreover, we found that the m 6 A methyltransferase METTL14 negatively correlates with FTO function on esophageal cancer progression. By using transcriptome-wide m 6 A-Seq and RNA-Seq assays, we identified AKT3 is the target of FTO, which acts in concert in esophageal cancer tumorigenesis and metastasis. Moreover, loss and gain functional studies confirm that YTHDF1 mediates m 6 A-increased translation of AKT3 mRNA.
Conclusion : Our results uncovered an METTL14/FTO/YTHDF1/AKT3 signaling network that regulates the esophageal cancer progression.
PTCSC1 Promotes Bladder Cancer Progression by AKT Pathway
Authors: jiang xingkang , ren shaokun , zhang zheng , zhang wei 
Published: July 2021

Abstract
In bladder cancer the expression of PTCSC1is elevated, but how PTCSC1influencetumor progression are still unclear. We found that in human bladder cancer PTCSC1 is upregulated. The study showedthat the expression level of PTCSC1 is higher in bladder cancer tissuesthan that of PTCSC1 in para-carcinoma tissue. Furthermore, PTCSC1promoted bladder cancer cell migration and invasion, and decreased expression of PTCSC1 inhibited the expression of matrix metalloprotease MMP2and MMP9, and increased the expression level of E-cadherin. PTCSC1 promoted tumor growth in a mouse model of human bladder cancer. Additionally,PTCSC1 shRNA caused a significant decrease in p-AKTexpression in T24 cells and BIU-87 cells, but the overexpression ofPTCSC1got an opposite result.Allthe results showed that PTCSC1 can influencebladder cancer cellmigration and invasion ability by the AKT pathways. PTCSC1 may be an effective therapeutic target in bladder cancer.
The evolution of life history strategies in plants and its relationship to the evolution of protective cellular mechanisms against reactive oxygen species
Authors: Zakhary Abraam , Nagarajan Aashika , Ngo Charlotte , Saidajan Marwa , Babbar Supreet , Brown Jason 
Published: July 2021

Abstract
Purpose. The Oxidative Stress Theory of Aging (OSTA) states that accumulation of oxidative damage is a major contributor to aging; however, until now, no studies have examined whether perennial plants exhibit cellular mechanisms to better protect themselves against oxidative damage than annual plants, nor how these mechanisms may have evolved. Methods. We undertook three approaches to evaluate the capacity for annual and perennial plants to resist oxidative damage. The first approach involved using an electrolyte leakage assay to assess the rate of cellular damage in leaves exposed to exogenous H 2 O 2 . The second approach involved determining the concentration of exogenous H 2 O 2 required to maximize germination rates, which provides insight about the antioxidant levels in seeds. The third approach involved assessing the susceptibility of chlorophyll a and chlorophyll b to exogenous H 2 O 2 and determining chlorophyll a/b ratios. We also conducted an ancestral state reconstruction of life history strategies in order to interpret our results in an evolutionary context. Results. Leaves from deciduous and evergreen perennials showed a lower rate of cellular damage than leaves from annuals when exposed to exogenous H 2 O 2 . Seeds from deciduous perennials—but not biennials or evergreen perennials—required a higher H 2 O 2 concentration to maximize germination rate compared to seeds from annuals, suggesting that seeds from deciduous perennials have higher antioxidant levels. Although chlorophyll b was found to be more susceptible to damage from exogenous H 2 O 2 , chlorophyll a/b ratios did not differ among life history strategies. Ancestral state reconstruction revealed that the ancestral plant was most likely an evergreen perennial. Conclusion. Our results showcase that resistance to oxidative stress is necessary for perennial plants to survive over multiple years. The mechanisms responsible for the increased tolerance of perennial species to oxidative stress has not been fully elucidated by this study, but it does not involve changes to chlorophyll a/b ratios, as such changes could disrupt photosynthesis. The developmental onset of these protective mechanisms was delayed in evergreen perennials compared to deciduous perennials, perhaps because the ancestral evergreens were primarily focused on rapid colonization of the terrestrial environment, which requires faster germination rates induced by higher H 2 O 2 levels.