bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Four-Gene-Based Prognostic Model Predicts Overall Survival in Patients With Cutaneous Melanoma
Authors: Tong Xiaoxia , Qu Xiaofei , Wang Mengyun 
Published: March 2021

BackgroundCutaneous melanoma (CM) is one of the most aggressive cancers with highly metastatic ability. To make things worse, there are limited effective therapies to treat advanced CM. Our study aimed to investigate new biomarkers for CM prognosis and establish a novel risk score system in CM.MethodsGene expression data of CM from Gene Expression Omnibus (GEO) datasets were downloaded and analyzed to identify differentially expressed genes (DEGs). The overlapped DEGs were then verified for prognosis analysis by univariate and multivariate COX regression in The Cancer Genome Atlas (TCGA) datasets. Based on the gene signature of multiple survival associated DEGs, a risk score model was established, and its prognostic and predictive role was estimated through Kaplan-Meier (K-M) analysis and log-rank test. Furthermore, the correlations between prognosis related genes expression and immune infiltrates were analyzed via Tumor Immune Estimation Resource (TIMER) site.ResultsA total of 103 DEGs were obtained based on GEO cohorts, and four genes were verified in TCGA datasets. Subsequently, four genes (ADAMDEC1, GNLY, HSPA13, and TRIM29) model was developed by univariate and multivariate Cox regression analyses. The K-M plots showed that the high-risk group was associated with shortened survival than that in the low-risk group (P &lt; 0.0001). Multivariate analysis suggested that the model was an independent prognostic factor (high-risk vs. low-risk, HR= 2.06, P &lt; 0.001). Meanwhile, the high-risk group was prone to have larger breslow depth (P&lt; 0.001) and ulceration (P&lt; 0.001).ConclusionsThe four-gene risk score model functions well in predicting the prognosis and treatment response in CM and will be useful for guiding therapeutic strategies for CM patients. Additional clinical trials are needed to verify our findings.
Polysaccharide Isolated From Tetrastigma hemsleyanum Activates TLR4 in Macrophage Cell Lines and Enhances Immune Responses in OVA-Immunized and LLC-Bearing Mouse Models
Authors: Zhou Fang-mei , Chen Yu-chi , Jin Chao-ying , Qian Chao-dong , Zhu Bing-qi , Zhou Ying , Ding Zhi-shan , Wang Yi-qi 
Published: March 2021

Tetrastigmahemsleyanum Diels et Gilg is a valuable Chinese medicinal herb with a long history of clinical application. Our previous study isolated and characterized a purified polysaccharide from the aerial part of Tetrastigma hemsleyanum (SYQP) and found it having antipyretic and antitumor effects in mice. A preliminary mechanistic study suggests these effects may be related to the binding of toll-like receptor (TLR4). The objective of this study is to further explore the detailed stimulating characteristics of SYQP on TLR4 signaling pathway and its in vivo immune regulating effect. We use HEK-BLUE hTLR4, mouse and human macrophage cell lines, as research tools. In vitro results show SYQP activated HEK-BLUE hTLR4 instead of HEK-BLUE Null cells. The secretion and the mRNA expression of cytokines related to TLR4 signaling significantly increased after SYQP treatment in both PMA-induced THP-1 and RAW264.7 macrophage cell lines. The TLR4 antagonist TAK-242 can almost completely abolish this activation. Furthermore, molecules such as IRAK1, NF-κB, MAPKs, and IRF3 in both the MyD88 and TRIF branches were all activated without pathway selection. In vivo results show SYQP enhanced antigen-specific spleen lymphocyte proliferation and serum IgG levels in OVA-immunized C57BL/6 mice. Orally administered 200 mg/kg SYQP induced obvious tumor regression, spleen weight increase, and the upregulation of the mRNA expression of TLR4-related cytokines in Lewis lung carcinoma–bearing mice. These results indicate SYQP can act as both a human and mouse TLR4 agonist and enhance immune responses in mice (p &lt; 0.05). This study provides a basis for the development and utilization of SYQP as a new type of TLR4 agonist in the future.
Systematically Defined Informative Priors in Bayesian Estimation: An Empirical Application on the Transmission of Internalizing Symptoms Through Mother-Adolescent Interaction Behavior
Authors: Schulz Susanne , Zondervan-Zwijnenburg Mariëlle , Nelemans Stefanie A. , Veen Duco , Oldehinkel Albertine J. , Branje Susan , Meeus Wim 
Published: March 2021

BackgroundBayesian estimation with informative priors permits updating previous findings with new data, thus generating cumulative knowledge. To reduce subjectivity in the process, the present study emphasizes how to systematically weigh and specify informative priors and highlights the use of different aggregation methods using an empirical example that examined whether observed mother-adolescent positive and negative interaction behavior mediate the associations between maternal and adolescent internalizing symptoms across early to mid-adolescence in a 3-year longitudinal multi-method design.MethodsThe sample consisted of 102 mother-adolescent dyads (39.2% girls, Mage T1 = 13.0). Mothers and adolescents reported on their internalizing symptoms and their interaction behaviors were observed during a conflict task. We systematically searched for previous studies and used an expert-informed weighting system to account for their relevance. Subsequently, we aggregated the (power) priors using three methods: linear pooling, logarithmic pooling, and fitting a normal distribution to the linear pool by means of maximum likelihood estimation. We compared the impact of the three differently specified informative priors and default priors on the prior predictive distribution, shrinkage, and the posterior estimates.ResultsThe prior predictive distributions for the three informative priors were quite similar and centered around the observed data mean. The shrinkage results showed that the logarithmic pooled priors were least affected by the data. Most posterior estimates were similar across the different priors. Some previous studies contained extremely specific information, resulting in bimodal posterior distributions for the analyses with linear pooled prior distributions. The posteriors following the fitted normal priors and default priors were very similar. Overall, we found that maternal, but not adolescent, internalizing symptoms predicted subsequent mother-adolescent interaction behavior, whereas negative interaction behavior seemed to predict subsequent internalizing symptoms. Evidence regarding mediation effects remained limited.ConclusionA systematic search for previous information and an expert-built weighting system contribute to a clear specification of power priors. How information from multiple previous studies should be included in the prior depends on theoretical considerations (e.g., the prior is an updated Bayesian distribution), and may also be affected by pragmatic considerations regarding the impact of the previous results at hand (e.g., extremely specific previous results).
Intimate Partner Violence, Depression, and Anxiety Are Associated With Higher Perceived Stress Among Both Young Men and Women in Soweto and Durban, South Africa
Authors: Pakhomova Tatiana E. , Dietrich Janan Janine , Closson Kalysha , Smit Jenni , Hornschuh Stefanie , Smith Patricia , Beksinska Mags , Ndung'u Thumbi , Brockman Mark , Gray Glenda , Kaida Angela 
Published: March 2021

Objectives: Psychological stress is an important determinant of health, including for mental well-being and sexual health. However, little is known about the prevalence and psychosocial and sexual health correlates of perceived stress among young people in South Africa, where elevated life-stressors are an important driver of health inequities. This study examines the association between intimate partner violence (IPV), psychosocial and sexual health, and perceived stress, by gender, among South African adolescents and young adults.Methods: Using baseline survey data from AYAZAZI, a cohort study enrolling youth (16–24 years) from Durban and Soweto, we used the 10-item Perceived Stress Scale (PSS-10) to measure the degree to which an individual perceives their life situations as unpredictable, uncontrollable, and overloaded. Possible scores range between 0 and 40; higher scores indicating higher perceived stress. Crude and adjusted gender-stratified linear regression models examined associations between sexual health factors, experiences (young women) and perpetration (young men) of IPV, anxiety (APA 3-item Scale, ≥2 = probable anxiety), and depression (10-item CES-D Scale, ≥10 = probable depression) and perceived stress. Multivariable models adjusted for age, income, sexual orientation, and financial dependents.Results: Of the 425 AYAZAZI participants, 60% were young women. At baseline, 71.5% were students//learners and 77.2% earned ≤ ZAR1600 per month (~$100 USD). The PSS-10 had moderate reliability (α = 0.70 for young women, 0.64 for young men). Young women reported significantly higher mean PSS scores than young men [18.3 (6.3) vs. 16.4 (6.0)]. In adjusted linear regression models, among young women experiences of IPV (β = 4.33; 95% CI: 1.9, 6.8), probable depression (β = 6.63; 95% CI: 5.2, 8.1), and probable anxiety (β = 5.2; 95% CI: 3.6, 6.8) were significantly associated with higher PSS scores. Among young men, ever perpetrating IPV (β = 2.95; 95% CI: 0.3, 5.6), probable depression (β = 6; 95% CI: 4.3, 7.6), and probable anxiety (β = 3.9; 95% CI: 2.1, 5.8) were significantly associated with higher perceived stress.Conclusion: We found that probable depression, anxiety, perpetration of IPV among young men, and experiences of IPV among young women, were associated with higher perceived stress. Critical efforts are needed to address the gendered stressors of young men and women and implement services to address mental health within violence prevention efforts.
EGFR and KRAS Mutations in Lung Parenchyma of Subjects With EGFR/KRAS Wild-Type Lung Adenocarcinoma
Authors: Chalela Roberto , González-García Jose Gregorio , Khilzi Karys , Curull Víctor , Sánchez-Font Albert , Longarón Raquel , Rodrigo-Calvo María Teresa , Martín-Ontiyuelo Clara , Gea Joaquim , Bellosillo Beatríz 
Published: March 2021

The acquisition of driver mutations in non-tumoral cells appears to be very important during the carcinogenesis of adenocarcinoma (ADC). Recent studies suggest that cancer-related mutations may not necessarily be present only in malignant cells, but also in histologically “healthy cells”.Objective: to demonstrate the presence of EGFR or KRAS mutations in non-tumoral lung cells in subjects with ADC and negative mutational status.Results: mutations in EGFR or KRAS oncogenes were identified in the normal lung in 9.7% of the subjects. Exon 21 substitution L858R in EGFR was detected in two cases while the exon 19 deletion E746-A750 in the EGFR, the G12C and G12D substitutions in the KRAS were detected once. One patient presented three different mutations in the normal lung parenchyma (EGFR_L858R, KRAS_G12C and KRAS_G12D). The negative-mutation status of the tumor and the mutations detected in the “normal lung” were confirmed using highly sensitive and specific TaqMan PCR (CAST-PCR). No differences were found in terms of progression, progression-free survival or overall survival during the 18 months follow-up.Conclusions: These results confirm the presence of driver mutations in the histologically normal lung parenchyma cells in the absence of mutations coexisting with the primary tumor.
GPU-Based Parallel Implementation of VLBI Correlator for Deep Space Exploration System
Authors: Zhang Fan , Zhao Chenxi , Han Songtao , Ma Fei , Xiang Deliang 
Published: March 2021

Very Long Baseline Interferometry (VLBI) solution can yield accurate information of angular position, and has been successfully used in the field of deep space exploration, such as astrophysics, imaging, detector positioning, and so on. The increase in VLBI data volume puts higher demands on efficient processing. Essentially, the main step of VLBI is the correlation processing, through which the angular position can be calculated. Since the VLBI correlation processing is both computation-intensive and data-intensive, the CPU cluster is usually employed in practical application to perform complex distributed computation. In this paper, we propose a parallel implementation of VLBI correlator based on graphics processing unit (GPU) to realize a more efficient and economical angular position calculation of deep space target. On the basis of massively GPU parallel computing, the coalesced access strategy and the parallel pipeline strategy are introduced to further accelerate the VLBI correlator. Experimental results show that the optimized GPU-based VLBI method can meet the real-time processing requirements of the received data stream. Compared with the sequential method, the proposed approach can reach a 224.1 × calculation speedup, and a 36.8 × application speedup. Compared with the multi-CPUs method, it can achieve 28.6 × calculation speedup and 4.7 × application speedup.
Split Ring Resonator-Based Bandstop Filter for Improving Isolation in Compact MIMO Antenna
Authors: Islam Hashinur , Das Saumya , Ali Tanweer , Kumar Pradeep , Dhar Sourav , Bose Tanushree 
Published: March 2021

The ever-growing expectation for high data rates has led to the introduction of multiple-input multiple-output (MIMO) technologies to wireless connectivity. Such a system requires an MIMO antenna with high isolation. At the same time, the MIMO dimension should not be compromised for achieving high isolation. Thus, isolation techniques that do not allow an increase in dimension need to be fostered for MIMO antenna design. In this paper, a novel low-profile, miniaturized MIMO antenna with high isolation was developed considering a split ring resonator (SRR)-based bandstop filter as a decoupling network. The bandstop filter was designed with a unit cell split ring resonator structure and was deployed between two closely spaced monopole MIMO antenna elements to obtain isolation as high as 39.25 dB at 2.61 GHz. Two open-circuit stub lines were attached with the MIMO feeding network to achieve good impedance matching at resonance frequency. The proposed antenna exhibited a peak gain of 3.8 dBi and radiation efficiency of 84%. It had a low envelop correlation coefficient (ECC < 0.12), high diversity gain (DG > 9.95 dB), low mean effective gain ratio (MEG 1/MEG 2 < 0.05 dB), and low channel capacity loss (CCL < 0.042 bits/s/Hz) at resonance frequency. The overall antenna dimension was restricted to 44 mm ×22 mm (0.38 λ0×0.19 λ0) for its easy integration in compact wireless devices.
Efectividad del tratamiento basado en neuronas espejo aplicado a pacientes con secuelas de accidente cerebro vascular
Authors: Padilla Valverde Sánder Felipe , Gazel Morales Alejandro 
Published: March 2021

Introducción: el objetivo de esta revisión narrativa fue analizar la efectividad del tratamiento basado en neuronas espejo (NE), para la recuperación funcional de pacientes con secuelas de accidente cerebrovascular. Metodología: estudio de revisión narrativa basada en la revisión bibliográfica de artículos científicos publicados en las bases de datos: EBSCO host (Medline, MedicLatina, Rehabilitation & Sports Medicine Source, GreenFILE, Library, Information Science & Technology Abstracts), PEDro, Dialnet y PubMed. Se incluyeron artículos científicos publicados del 2016 al 2020, que trataran sobre el tratamiento basado en NE para la recuperación de secuelas de accidente cerebrovascular. Se incluyeron 40 artículos en la revisión, escritos en inglés y español. Resultados: existen múltiples alternativas de tratamiento basado en NE, las cuales son: terapia espejo, realidad virtual, imaginería motora, video-terapia y terapia de acción observación. Estos tratamientos promueven la neuroplasticidad y el reaprendizaje motor. Se demostró que el tratamiento basado en NE es eficaz para la reducción del dolor, la espasticidad y la intensidad de los síntomas percibidos, también para mejorar la funcionalidad del miembro superior, el nivel de independencia, la activación de la musculatura de miembros inferiores, el rango de movimiento de la dorsiflexión, el equilibrio, la marcha, el balance y el control postural. Lo anterior se concluyó luego de analizar resultados positivos o mejoras significativas en un total de 35 artículos. Se comprobó que el tratamiento basado en NE en combinación con el manejo convencional o con otras opciones terapéuticas muestra mayor efectividad que al utilizar cualquiera de estos dos abordajes de forma aislada. Conclusión: existe una amplia variedad de alternativas de tratamiento basado en NE las cuales, en combinación con otras alternativas de tratamiento, han demostrado efectividad para la recuperación de funcional de pacientes con secuelas de accidente cerebrovascular. La evaluación del paciente es vital para comprender sus limitaciones y necesidades para así poder realizar las combinaciones terapéuticas que serán más efectivas.
FLORÜRLÜ VERNİK UYGULAMASININ DİŞ SAĞLIĞI TARAMA SONUÇLARI İLE DEĞERLENDİRİLMESİ
Authors: AYDIN KILINÇ Zeynep , SIRCAN KÜÇÜKSAYAN Aslınur 
Published: March 2021

Giriş ve Amaç: Ağız ve diş hastalıkları, toplumumuzda sık olarak görülen, genel sağlığı olumsuz yönde etkileyebilen ve koruyucu önlemler alındığı takdirde engellenebilen hastalıklardır. Bu çalışmanın amacı florürlü vernik uygulaması yapılan ve yapılmayan çocukların diş sağlığı tarama sonuçları incelenerek; florürlü vernik uygulamasını, süt molar dişlerindeki çürük sayıları, diş fırçalama sıklığı, diş hekimine gitme nedenleri ve ailelerin eğitim durumu açısından değerlendirmektir.
Gereç ve Yöntem: İlçe Sağlık Müdürlüğü tarafından yapılan florürlü vernik uygulaması kapsamında, 2017-2018 eğitim öğretim yılı 1.sınıf öğrencileri arasından rastgele seçilen 200 öğrenci çalışmaya dâhil edilmiştir. Anket sonuçları ve diş taramalarından elde edilen bilgiler değerlendirilerek; uygulama yapılan ve yapılmayan çocukların çürük indeksi, diş fırçalama sıklığı, diş hekimine gitme nedenleri ve ailelerin eğitim durumu karşılaştırılması yapıldı.
Bulgular: Florürlü vernik uygulaması yapılan ve yapılmayan çocukların çürük indeksi ve diş fırçalama sıklığı arasında istatistiksel olarak anlamlı fark bulunmadı. Çalışmaya dâhil edilen çocukların %60’ında diş çürüğü olduğu bulundu. Ailelerinin diş sağlığı konusundaki bilinç düzeyleri değerlendirildiğinde florürlü vernik uygulamasına izin vermeyen ailelerin %30’u üniversite düzeyinde eğitime sahipken, izin veren ailelerde üniversite düzeyinde eğitim %21 olduğu bulundu. İzin verilmeyen çocukların %46’sının hiç çürükleri yokken, izin verilen çocukların %34’ünün hiç çürüğü olmadığı görüldü. Ayrıca çalışmaya dahil edilen çocukların %48,5’unun hiç diş hekimine gitmediği ve uygulama yapılmayan çocukların %68’i dişlerini düzenli fırçalarken, uygulama yapılan çocuklarda bu oranın %62 olduğu görüldü.
Sonuç: Yaptığımız bu çalışmada florürlü vernik uygulamasına izin vermeyen ailelerin eğitim seviyelerinin izin verenlere göre daha yüksek olduğu belirlendi. Florürlü vernik uygulaması yapılan çocukların yapılmayanlara göre çürük diş sayısının daha fazla, diş fırçalama sıklığının daha az olduğu belirlendi. Ayrıca diş hekimine gitme oranının uygulama yapılan çocuklarda yapılmayanlara göre daha az oldu belirlendi.
Communitarian Theory and Andalusian Imagery in Carmel Bird’s Fiction. An Interview
Authors: Rodríguez-Salas Gerardo 
Published: March 2021

Australian writer Carmel Bird writes fiction that, while being highly individual and varied, settles within the Australian traditions of both Peter Carey’s fabulism and Thea Astley’s humane wit. As William H. Wilde, Joy Hooton and Barry Andrews state (1994), Bird is a “witty writer with a wide but always highly original tonal range”, who “raises what is often potentially sinister or horrific to something approaching comedy. Disease, deaths and violence are staples in her fictional world, which has similarities with Barbara Hanrahan’s Gothic sensuality and feminist irony, although Bird’s deadpan humour is a distinctive, determining element”. The present interview focuses on an unexplored area in Bird—Andalusia, Spain—which, paradoxically, becomes the backcloth of some of her fiction—like the recent Child of the Twilight (2010)—and a prolific source of inspiration. The following pages explore Bird’s Andalusian/Spanish visions as regards nationalistic, religious, and cultural constructions. To that end, the theoretical communitarian discussion of figures like Ernest Gellner, Ferdinand Tönnies, Benedict Anderson, Jean-Luc Nancy and Maurice Blanchot will prove useful in the structural framework of this interview. Bird herself clarifies that her contribution is not offered from an academic perspective; she speaks about herself as a writer largely unaffected by academic bias. However, communitarian theorisation will prove useful in clarifying her depiction of nationalistic and religious values, while, in the process, she sheds some light on the slippery concept of “Australian writing” and the construction of Spanish cultural values from the perspective of an Australian writer. This interview offers a fresh rendition marked by the humorous, spontaneous and truthful tone that characterises Bird’s fiction.
Keputusan Investasi, Pendanaan, Kebijakan Dividen dan Price to Book Value Perusahaan Pertambangan di Bursa Efek Indonesia
Authors: Alipudin Asep , Hidayat Nur 
Published: March 2021

A B S T R A C T
The financial performance of the mining sector was having decline from 2011 to 2012. Price to book value illustrates the value of the company. This study examines the effect of investment decisions, financing, and dividend policy on price to book value. Samples were tested by 50 years of data mining company for 5 years. The results showed that the investment decisions affect the value of the company. The research result shows that financing policy and dividend policy no significant effect on firm value. This research contributes for empirical evidence related to the factors that affect the value of the company in the mining sector.
A B S T R A K
Kinerja keuangan sektor pertambangan sedang mengalami penurunan dari tahun 2011 sampai 2012. Price to Book Value menggambarkan nilai dari perusahaan. Penelitian ini menguji pengaruh keputusan investasi, pendanaan, dan kebijakan dividen terhadap price to book value. Sampel diuji sebanyak 50 data tahun perusahaan pertambangan selama 5 tahun. Hasil penelitian menunjukkan bahwa keputusan investasi berpengaruh terhadap nilai perusahaan. Adapun pendanaan dan kebijakan deviden berpengaruh tidak signifikan terhadap nilai perusahaan. Riset ini memberikan kontribusi tentang bukti empiris terkait faktor-faktor yang mempengaruhi nilai perusahaan pada sektor pertambangan moral.
JEL Classification G14, M21