bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk-benefit assessment of major versus minor osteotomies for flexible and rigid cervical deformity correction
Authors: Passias Peter Gust , Passfall Lara , Horn Samantha R. , Pierce Katherine E. , Lafage Virginie , Lafage Renaud , Smith Justin S. , Line Breton G. , Mundis Gregory M. , Eastlack Robert , Diebo Bassel G. , Protopsaltis Themistocles S. , Kim Han Jo , Scheer Justin , Burton Douglas C. , Hart Robert A. , Schwab Frank J. , Bess Shay , Ames Christopher P. , Shaffrey Christopher I. 
Published: September 2021

Introduction:
Osteotomies are commonly performed to correct sagittal malalignment in cervical deformity (CD). However, the risks and benefits of performing a major osteotomy for cervical deformity correction have been understudied. The objective of this retrospective cohort study was to investigate the risks and benefits of performing a major osteotomy for CD correction.

Methods:
Patients stratified based on major osteotomy (MAJ) or minor (MIN). Independent t-tests and Chi-squared tests were used to assess differences between MAJ and MIN. A sub-analysis compared patients with flexible versus rigid CL.

Results:
137 CD patients were included (62 years, 65% F). 19.0% CD patients underwent a MAJ osteotomy. After propensity score matching for cSVA, 52 patients were included. About 19.0% CD patients underwent a MAJ osteotomy. MAJ patients had more minor complications (P = 0.045), despite similar surgical outcomes as MIN. At 3M, MAJ and MIN patients had similar NDI, mJOA, and EQ5D scores, however by 1 year, MAJ patients reached MCID for NDI less than MIN patients (P = 0.003). MAJ patients with rigid deformities had higher rates of complications (79% vs. 29%, P = 0.056) and were less likely to show improvement in NDI at 1 year (0.95 vs. 0.54, P = 0.027). Both groups had similar sagittal realignment at 1 year (all P > 0.05).

Conclusions:
Cervical deformity patients who underwent a major osteotomy had similar clinical outcomes at 3-months but worse outcomes at 1-year as compared to minor osteotomies, likely due to differences in baseline deformity. Patients with rigid deformities who underwent a major osteotomy had higher complication rates and worse clinical improvement despite similar realignment at 1 year.
Reevaluation of the Electroencephalogram Recordings of Patients with Nonconvulsive Status Epilepticus by Using Salzburg Consensus Criteria
Authors: Timer Emin , Yılgor Abdullah , Oguz-Akarsu Emel , Bebek Nerses , Baykan Betul 
Published: September 2021

Objective:
Nonconvulsive status epilepticus (NCSE) is a challenge to diagnose in some cases, and recently, Salzburg consensus criteria for NCSE (SCC-NCSE) were developed to contribute to clinical practice. We aimed to investigate their validity and usefulness by reevaluating the electroencephalogram (EEG) examinations of our patients in this study.

Materials and Methods:
We retrospectively evaluated all EEG recordings of patients diagnosed with NCSE by experienced clinical neurophysiologists in our EEG laboratory over a period of 2 years. Two neurologists trained in EEG reanalyzed all EEG data and categorized these patients as NCSE, possible NCSE, or non-NCSE using the SCC-NCSE.

Results:
Twenty-nine patients with a mean age of 31.5 ± 25.9 were reanalyzed. According to the SCC-NCSE, 24 patients (82.7%) were diagnosed as NCSE. Eighteen patients (62%) who fulfilled all SCC-NCSE were diagnosed as NCSE, whereas six patients (20.7%) were diagnosed only as possible NCSE. Five patients (17.3%) did not fulfill SCC-NCSE; the reasons are the lack of additional secondary criteria in 2 patients with encephalopathy, the absence of full compliance with the criteria in other 2 patients, and a diagnosis of electrical status epilepticus during sleep in the last patient.

Conclusion:
The results of our study show that SCC-NCSE is highly consistent with clinical practice to decide for the diagnosis of NCSE. The evaluation of NCSE according to a set of new standardized criteria is thought to be difficult in practice, but it provides a more objective assessment. Therefore, we believe that its use should be encouraged to increase experience and the possibility of correct diagnosis.
An Adaptive Intervention Trial Design for Finding the Optimal Integrated Strategies for Malaria Control and Elimination in Africa: A Model Simulation Study
Authors: Zhou Guofa , Lee Ming-chieh , Wang Xiaoming , Zhong Daibin , Hemming-Schroeder Elizabeth , Yan Guiyun 
Published: September 2021

ABSTRACT.
There are a number of available and emerging malaria intervention tools that require innovative trial designs to find the optimal combinations at given epidemiologic settings. We simulated intervention strategies based on adaptive interventions, which included long-lasting insecticidal nets (LLINs), piperonyl butoxide–treated LLINs (PBO-LLINs), indoor residual spraying (IRS), and long-lasting microbial larviciding (LLML). The aims were to determine if PBO-LLINs or LLIN+IRS combination is more effective for initial interventions than LLINs and to identify the most effective intervention. We used a clustered, randomized adaptive trial design with malaria infection prevalence (MIP) as the outcome variable. The results indicate that during the initial stage of interventions, compared with regular LLINs, PBO-LLINs (relative reduction [RR]: 29.3%) and LLIN plus IRS with alternative-insecticide (RR: 26.8%) significantly reduced MIP. In the subsequent interventions, adding alternative insecticide IRS (RR: 23.8%) or LLML (RR: 31.2%) to existing PBO-LLIN was effective in further reducing MIP. During the next stage of interventions, adding LLML on top of PBO-LLIN+IRS (with alternative insecticides) had a significant impact on MIP (RR: 39.2%). However, adding IRS (with alternative insecticides) on top of PBO-LLIN+LLML did not significantly reduce MIP (11.6%). Overall, in clusters initiated with PBO-LLIN, adding LLML would be the most effective strategy in reducing MIP; in clusters initiated with LLIN+IRS, replacing LLIN+IRS with PBO-LLIN and LLML would be the most effective in reducing MIP. This study provides a new pathway for informing the optimal integrated malaria vector interventions, and the new strategy can be tested in field trials.
Pediatric Hospital Medicine and Global Health: A Fitting Niche for an Emerging Subspecialty
Authors: Haq Heather , Rule Amy R. L. , Coria Alexandra , Thahane Lineo K. , Duperval Regina M. , Barnes Adelaide , Condurache Tania , Ferrer Kathy , Shenoy Michelle J. , Mendoza Joanne , Russ Christiana M. 
Published: September 2021

ABSTRACT.
As North American hospitals serve increasingly diverse patient populations, including recent immigrants, refugees, and returned travelers, all pediatric hospitalists (PHs) require foundational competency in global health, and a subset of PHs are carving out niches focused in global health. Pediatric hospitalists are uniquely positioned to collaborate with low- and middle-income country clinicians and child health advocates to improve the health of hospitalized children worldwide. Using the 2018 WHO standards for improving the quality of care for children and adolescents worldwide, we describe how PHs’ skills align closely with what the WHO and others have identified as essential elements to bring high-quality, sustainable care to children in low- and middle-income countries. Furthermore, North American global health hospitalists bring home expertise that reciprocally benefits their home institutions.
Case Report: Gastrointestinal Basidiobolomycosis with Multi-Organ Involvement Presented with Intussusception
Authors: Jafarpour Zahra , Pouladfar Gholamreza , Dehghan Alireza , Anbardar Mohammad Hossein , Foroutan Hamid Reza 
Published: September 2021

ABSTRACT.
Gastrointestinal basidiobolomycosis (GIB) is a rare, life-threatening fungal infection affecting immunocompetent individuals in tropical and subtropical regions. A diverse presentation of GIB has been reported, but no report has yet been published on intussusception. We describe a 23-month-old immunocompetent boy from a subtropical area in Iran who presented with intussusception. Prolonged fever, an abdominal mass, hepatomegaly, high erythrocyte sedimentation rate, and peripheral eosinophilia strongly suggested GIB. Accordingly, GIB was diagnosed based on the characteristic histopathology (the Splendore-Hoeppli phenomenon) detected in a liver sample taken via biopsy. Exploratory laparotomy showed several organs, including the colon, gall bladder, liver, and abdominal wall, were involved. Antifungal therapy with trimethoprim/sulfamethoxazole, liposomal amphotericin B, a saturated solution of potassium iodide, and surgical resection of involved tissues were used with improved outcome. The presence of non-septate fungal hyphal elements in the colonic mucosa led to the thickening of the bowel wall, leading to secondary intussusception.
Learning-by-Teaching Approach Improves Dengue Knowledge in Children and Parents
Authors: Hermida Maria Julia , Perez Santangelo Agustín , Calero Cecilia Inés , Goizueta Carolina , Espinosa Manuel , Sigman Mariano 
Published: September 2021

ABSTRACT.
There is narrow evidence on which strategies are most effective for disseminating information on dengue prevention. This is particularly relevant because social habits have a great prevention capacity for dengue. We investigated how effective are children as health educators, and how much they learn as they teach. We recruited 142 children and 97 parents in Argentina’s tropical area for two cluster randomized parallel trials. In Study 1, we compared the dynamics of dengue knowledge of 10-year-old children who—after receiving a dengue talk—1) listened to an unrelated topic; 2) read a booklet with information about dengue, 3) taught their parents about dengue, or 4) taught their parents about dengue, using the booklet. In Study 2, we assessed whether the parents’ dengue knowledge changed after interacting with their children, in comparison with parents learning about dengue from an expert or about an unrelated topic. Children that taught their parents what they learned, using a booklet, showed 2.53 more correct responses (95% CI [0.20, 4.85]; P = 0.027) than children who listened to an unrelated topic. This style of teaching also serves to effectively propagate knowledge: parents learned from their children the same as from an expert; and significantly more than parents who learned about an unrelated topic. Parents learned from their children even if they were taught with booklets (1.49, 95% CI [0.01, 2.96]; P = 0.048) or without (1.94, 95% CI [0.44, 3.44]; P = 0.006). Specifically, after being taught by their children, parents showed on average 1.49 (if they were taught with a booklet) and 1.94 (without booklet) more correct responses than parents that learned about an unrelated topic. The simple action of prompting children to teach consolidated their own knowledge and broadcasted it effectively to their parents. This strategy is a potential low to no-cost method for sharing information about dengue prevention.
An Exploration of Knowledge, Attitude, and Practices of Physicians toward Pharmacovigilance at Tertiary Care Hospitals in Khyber-Pakhtunkhwa Province, Pakistan
Authors: Sharif Muhammad Junaid Hassan , Murtaza Ghulam , Kharaba Zelal , Ibrahim Nihal Abdalla , Ismail Mohammad , Mannan Abdul , Buabeid Manal , Huang Xianju , Khan Shujaat Ali , Hayat Khezar 
Published: September 2021

ABSTRACT.
Drug safety assures the effectiveness, safety, and security of drugs, vaccines, and other biologicals to protect public health. Medication-related errors coupled with unjudicial medication practices often cause a catastrophic impact on the healthcare system globally. The present study aimed to assess the knowledge, attitude, and practice of physicians toward pharmacovigilance and barriers to adverse drug reaction (ADR) reporting at tertiary care hospitals in Khyber-Pakhtunkhwa (KP) province, Pakistan. A descriptive cross-sectional study was conducted among registered doctors working in seven tertiary care hospitals from seven administrative divisions of KP province of Pakistan from July 2019 to March 2020. During the study period, 358 physicians who fulfilled the inclusion criteria and agreed to participate completed and returned the validated structured questionnaires. Descriptive and inferential statistics were applied for data analysis. The majority of physicians had poor knowledge (81.3%) regarding pharmacovigilance along with poor reporting practices (94.9%), although (96.5%) had a positive attitude toward ADR reporting. A significant barrier identified was the unavailability of reporting forms (95.9%), whereas mandatory ADR reporting (96.2%) was the major factor to encourage ADR reporting. Physicians aged ≥ 41 and experience ≥ 11 years had significantly more knowledge than other categories (P < 0.001). Significant association (P < 0.001) of physicians’ knowledge and practice were found where 77.2% of the participants having poor knowledge reported poor practices. Physicians’ understanding of pharmacovigilance was suboptimal, although they have a positive attitude toward ADR reporting. Thus, there is a need for continuous education and training programs to support pharmacovigilance activities that could improve physicians’ understanding.
Bullous Scabies: Clinical, Dermoscopic, and Pathologic Characteristics of Ten Patients
Authors: Li Feng-Zeng , Jia Meng , Chen Ke-Jun , Ye Qian , Fang Sheng 
Published: September 2021

ABSTRACT.
Bullous scabies (BS) is a rare atypical clinical variant of scabies and is easily confused with bullous disorders. The diagnosis of BS is always a challenge, and physicians often misdiagnose BS patients. Patients with BS admitted from 2012 to 2020 were enrolled in this study. The clinical, dermoscopic, and pathological characteristics of the patients were analyzed retrospectively. Ten patients with BS were enrolled in this study. Seven of the 10 patients were male. The bullae were most commonly found on the thighs and arms (80% of patients). Only 30% of patients (3/10) tested positive for mites and/or eggs by the initial skin scraping, but 100% (5/5) of the patients who received dermoscopy tested positive. Among these 10 patients, only five received a skin biopsy. Subepidermal (4/5) and intraepidermal (1/5) bullae with eosinophil and neutrophil infiltration were observed in five patients. Direct immunofluorescence (DIF) indicated linear deposition of IgG in the basement membrane zone in three patients. Physicians should consider the possibility of BS in patients with blisters, pruritus, and poor response to corticosteroids. Dermoscopy should be prioritized for the differential diagnosis of BS to exclude other bullous disorders. Finally, a biopsy should be performed on each patient with bullae.
impacto de factores externos en la estructura organizacional de las mypes en Nogales, Sonora Luján Gil
Authors: Luján Gil Juan Manuel , Perea Camacho Ana Luisa , González López Adrián , Chiquete Bermúdez Rosa Isela 
Published: September 2021

El artículo muestra las correlaciones existentes entre la influencia percibida de los factores externos sobre la estructura organizacional de las Mype’s del municipio de Nogales, Sonora. Su fundamentación se da a partir de la importancia del análisis de factores externos para la planeación estratégica de una empresa. Se encontró que, en Nogales, Sonora existe una correlación de 0.095 ** entre la percepción de influencia de los factores externos y la estructura organizacional. El artículo aborda a detalle las correlaciones existentes y establece la implementación del Perfil de Oportunidades y Amenazas para medir su impacto.
Abstract
The article shows the correlations between the perceived influence of external factors on the organizational structure of Mype's in the municipality of Nogales, Sonora. Its foundation is based on the importance of analyzing external factors for the strategic planning of a company. It was found that, in Nogales, Sonora there is a correlation of 0.095 ** between the perception of influence of external factors and the organizational structure. The article deals in detail with the existing correlations and establishes the implementation of the Opportunities and Threats Profile to measure its impact.
análisis de las actividades de mercadotecnia como factor de permanencia de las mypes en Paraíso, Tabasco
Authors: De la Cruz Alcudia Abi Roxana , Ligonio Hernández Nínive , Valenzuela Córdova Florelis , de la  Cruz González Flor 
Published: September 2021

El objetivo de este artículo es generar información que sirva como punto de partida para identificar áreas de oportunidad y de mejora en las Mypes del municipio de Paraíso, Tabasco con la finalidad de incrementar la competitividad y lograr la permanencia de las mismas. Para ello, se hizo un análisis de los resultados de las principales actividades de mercadotecnia que se efectúan en las Mypes del municipio y se determinó el impacto de dichas actividades en su permanencia y crecimiento en el mercado. El estudio se realizó a partir del método cuantitativo con un alcance descriptivo, donde se identifican a las empresas que dentro de sus procesos promueven esfuerzos e implementan acciones en materia de mercadotecnia elevando su competitividad.
Abstract
The objective of this article is to generate information that serves as a starting point to identify areas of opportunity and improvement in the Mypes of the municipality of Paraíso, Tabasco in order to increase competitiveness and achieve their permanence. To do this, an analysis was made of the results of the main marketing activities that take place in the Mypes of the municipality and the impact of these activities on their permanence and growth in the market was determined. The study was carried out using the quantitative method with a descriptive scope, where companies that promote their efforts and implement actions in marketing matters are identified, increasing their competitiveness.
Biomechanical changes in women with chronic pelvic pain: a case-control study
Authors: M. Elbesh Rovan , A. Hamada Hamada , A. Elanen Mohamed , M. Yousef Amel , Mohamed Shousha Tamer , Reda Mohamed Rania 
Published: September 2021

PurposeChronic pelvic pain can influence women’s quality of life and activity levels; it can lead to several adverse side effects, such as changes in posture and biomechanical alignment. The purpose of this study was to determine the biomechanical changes that occur in women experiencing chronic pelvic pain, either cyclic or noncyclic.MethodsA case-control study was conducted among 60 females from the Gynecology Physiotherapy Clinic of El-Hosary Women Health Care in 6th of October city. The participants were assigned into 3 groups: cyclic chronic pelvic pain group (A), noncyclic chronic pelvic pain group (B), and normal women group (C). An inclinometer was used to assess biomechanical changes in the angles of the cervical, thoracic, and lumbar region; furthermore, a pelvic inclinometer served to measure the pelvic inclination angle.ResultsStatistical analysis revealed that there was a significant increase in biomechanical variables at the lumbar, thoracic, and cervical angles in group B compared with groups A and C and in group A compared with group C. Moreover, there was a significant increase in right and left pelvic inclination angles in groups A and B compared with group C, and no significant difference was observed between groups A and B.ConclusionsBiomechanical alignment changes are seen more frequently in women with noncyclic chronic pelvic pain and cyclic chronic pelvic pain than in normal women.
SAFETY AND EFFICACY OF STEM CELL THERAPY FOR TREATMENT SEVERE TRAUMATIC BRAIN INJURY
Authors: Viet Quang Hien Nguyen , Hoang Duy Minh Le , Thi Dieu Ngan Phan , Gia Vinh Le , Viet Quang Nguyen , Thi Thuy Hoa Phan , Thi Cam Ha Che 
Published: September 2021

Traumatic brain injury (TBI) is a complicated topic.TBI has expensive treatment, sequelae, high mortality and efficient therapeutic strategies for TBI are urgently needed. Patients with severe TBI account for 10% of all traumatic brain injury patients, but more than 80% of patients who die from traumatic brain injury are in this group of patients. That proves the danger of severe TBI. Mesenchymal stem cells (MSCs) are multipotent cells with high proliferative and self-renewal capacities, as well as immunomodulatory and neuroregenerative effects. MSCshave been shown to treat TBI and significantly reduce inflammation of injured tissue. In the present study, we evaluated the quality and effectiveness of mesenchymal stem cell transplantation with the graft dose of 9x106cells/kg. Clinical indexes (Pulse, temperature, SBP, HATTr, HATTB, GCS) and subclinical (Hepatic index, kidney, cortisol, lactate, glucose, hematological index, respiratory index) were monitored on 60 patients within 6 months.
The results showed that the recovery journey is different for every person with the graft dose of 6-9x106 cells/kg, but there were no adverse complications for the patients, the clinical and paraclinical indicators were stable. No significant side effects were observed during the trial as well as after 6 months of treatment. The MSC transfusions significantly increased the life quality patients; reduced brain damage and increased HSC counts. Inflammatory cytokines (IL-6) levels decreased and GCS increased in the MSC transfusion group, indicating that the patient's health improved.
Pengaruh Kualitas Pelayanan, Kepuasan, Trust, Brand Equity, Hospital Image dan Komitmen terhadap Loyalitas Pasien Umum
Authors: Sihombing Yolanda Anastasia 
Published: September 2021

The competition of bussines in hospital nowdays has been entering an era of high competition. Where all the hospital are trying to compete in maintaining the costumer they had. These experiment is intend to analyze the impression of good service, satisfactory, trust, commitment, brand equity, hospital image toward the outpatient. The method of research that used is quantitative with the design of cross-sectional. The analyze method(SEM) with smart PLS 2.0 an SPSS 18. The result of hipotesis resting using Structural Equation Model SEM is the loyality of outpatient in RS kesdam Cijantung is affected by the quality of services (23.19%) satisfactory(18.27%) trust(11.08%) commitment (6.28%) brand equaty (15.58%) and hospital image (9.35%) this is a direct influences (83.86%) while the indirect influence is (0.87%). The result of this analyze model explained (71.95%) of vary data and able to review fenomena that used in research, in contrary (28.05%) is explained as difficult component in this experiment. In conclusion toward this research that the services quality is the most influence variable that effect patient loyality.