bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Concept of Matrimonial Consent in Can. 1057 CIC 1983
Authors: Wąsik Wojciech Stanisław 
Published: December 2021

The article is devoted to matrimonial consent as described in Can. 1057 CIC/83, which has replaced the former Can. 1081 CIC/17. The regulation found in this canon emphasizes the importance of matrimonial consent and constitutes the basis for all reasons for the nullification of marriage. The analyzed norm, describing matrimonial consent in the positive aspect, was formulated in the personalistic spirit and adapted to Vatican II's teachings. Can. 1057 CIC/83 was placed among the norms introducing the De matrimonio of CIC/83 part, which resulted in ordering the vision of marriage in CIC/83. The studies on the normative content of Can. 1057 §1, CIC/83, focus on matrimonial consent, which establishes the matrimonial bond and is the only efficient cause of marriage, being a bilateral consensual contract and a sacrament for those baptized. The article discusses legal requirements assuring that consent will result in contracting a valid marriage. The article explains in detail the norm, according to which a defective matrimonial consent cannot be supplemented or replaced by another legal act. The article analyses the object of matrimonial consent in Can. 1057 §2, CIC/83, which was harmonized with the definition of marriage in Can. 1055 CIC/83. Ius in corpus is no longer such an object (as it narrows marriage to a communion finding fulfillment in the sexual and procreative sphere) but rather the parties to the contract, who give themselves to one another in an analogous sense (material object) and the communion for their entire life, in all its dimensions (formal object).
РЕЗУЛЬТАТИ ЕКСПЕРИМЕНТУ З ФОРМУВАННЯ ІНФОРМАЦІЙНО-АНАЛІТИЧНОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ БАКАЛАВРІВ КОМП’ЮТЕРНИХ НАУК
Authors: Прошкін Володимир , Бабкін Владислав 
Published: December 2021

У статті представлено результати перевірки ефективності педагогічних умов формування інформаційно-аналітичної компетентності майбутніх бакалаврів комп’ютерних наук: формування мотивації до інформаційно-аналітичної діяльності як чиннику професійного становлення та кар’єрного зростання майбутніх бакалаврів комп’ютерних наук; збагачення змісту навчальних дисциплін інформацією, спрямованою на опанування студентами системи знань про сутність інформаційно-аналітичної діяльності та набуття ними вмінь і навичок щодо її практичної реалізації; урізноманітнення процесу професійної підготовки студентів засобами проєктних методів навчання. Описано якісні зміни, що відбулися зі студентами експериментальної групи в контексті сформованості в них інформаційно-аналітичної компетентності. Представлено перспективи подальших наукових у руслі адаптації авторських педагогічних умов формування інформаційно-аналітичної компетентності студентів до реалізації в межах неформальної та інформальної освіти.
СПЕЦИФІКА МОДЕЛІ ПРОЄКТУВАННЯ ЦИФРОВИХ ОСВІТНІХ ТЕХНОЛОГІЙ У НАВЧАННІ МАЙБУТНІХ УЧИТЕЛІВ ПОЧАТКОВОЇ ШКОЛИ
Authors: Гринько Вікторія 
Published: December 2021

У статті представлено модель проєктування цифрових освітніх технологій у навчанні майбутніх учителів початкової школи. Розроблена модель містить цільовий, змістово-технологічний, операційно-технологічний та результативний складники. Зазначено, що процедура проєктування цифрової освітньої технології полягає у визначенні її можливостей щодо розвитку когнітивних, креативних, комунікативних та колаборативних умінь кожного здобувача відповідно до його особистого інтелектуального профілю. Визначено специфіку моделі, яка полягає в тому, що в ході навчання майбутніх учителів початкової школи проєктування цифрових освітніх технологій створюється змішане навчальне середовище, у якому розкриваються особистісні здібності кожного учасника. Варіативність моделі виявляється в можливостях її використання в ході вивчення однієї чи кількох дисциплін або в ході реалізації міждисциплінарних проєктів, а також у специфіці визначених для використання цифрових освітніх технологій.
ОСОБЛИВОСТІ ДИСТАНЦІЙНОГО НАВЧАННЯ ГРИ НА МУЗИЧНОМУ ІНСТРУМЕНТІ СТУДЕНТІВ ЗВО
Authors: Чугай Сергій 
Published: December 2021

У статті розглянуто нові можливості та підходи в організації дистанційного навчання, методи дистанційного навчання та ефективність їх використання у процесі гри на музичному інструменті. Висвітлено можливості дистанційного навчання в системі професійної підготовки. Розкрито теоретичні аспекти розвитку дистанційної освіти. Розглянуто особливості використання дистанційних технологій, які входять у практику сучасного освітнього процесу.
Визначено форми, методи роботи, які використовуються при дистанційному навчанні. Здійснено аналіз переваг та недоліків дистанційного навчання під час гри на музичному інструменті. Досліджено проблему формування самостійності студентів ЗВО під час дистанційного навчання грі на музичному інструменті. Проаналізовано значення формування самостійності студентів в процесі фахового навчання. Визначено, що самостійність студентів є складною професійно-особистісною властивістю, яка виникає на ґрунті засвоєння спеціальних (мистецьких) та психолого-педагогічних знань, втілюється в широкий спектр практичних умінь та навичок, спонукає до активних дій. Обґрунтовано організаційно-педагогічні умови формування самостійності студентів в процесі дистанційного навчання.
ТЕОРЕТИЧНИЙ АСПЕКТ ФОРМУВАННЯ МОВНОЇ ТА МОВЛЕННЄВОЇ КОМПЕТЕНТНОСТЕЙ ФАХІВЦІВ СФЕРИ ОБСЛУГОВУВАННЯ
Authors: Аксьонова Дар’я , Кулінка Юлія 
Published: December 2021

Стрімкі соціально-економічні зміни в суспільстві є рушійною силою для розвитку усіх сфер життєдіяльності людини та вимагають перебудови та удосконалення підходів та методів на всіх етапах освітнього процесу. Стаття присвячена проблемі теоретичних аспектів формування мовної особистості фахівців сфери обслуговування, висвітлюється актуальність проблеми виховання висококваліфікованого фахівця сфери обслуговування, перераховуються основні закони та нормативно-правові акти, які регулюють вимоки до підготовки фахівців сфери обслуговування. Розглянуто компетентнісний підхід до формування фахівців сфери обслуговування, як підґрунтя мовно культурного розвитку, виділені та охарактеризовані основні варіанти класифікацій компетентностей. Розкривається поняття мовного вміння та різні підходи до диференціації та стратегій спілкування. Аналізується комунікативна компетентність та основне коло вмінь, які вона охоплює. Досліджено лінгводидактичну літературу та зроблена порівняльна характеристика таких понять як «мовленнєва компетентність» та «мовна компетенція», визначена суть, структура та їх основні функції і структурні компоненти. У статті висвітлюється важливість володіння відповідними мовними нормами та навичками для формування професійної особистості фахівця сфери обслуговування, важливість комунікативної культури як засобу й умови формування професійної особистості.
Neural glymphatic system: Clinical implications and potential importance of melatonin
Authors: Bitar Ryan D , Torres-Garza Jorge L , Reiter Russel J , Phillips William T 
Published: December 2021

The central nervous system was thought to lack a lymphatic drainage until the recent discovery of the neural glymphatic system. This highly specialized waste disposal network includes classical lymphatic vessels in the dura that absorb fluid and metabolic by-products and debris from the underlying cerebrospinal fluid (CSF) in the subarachnoid space. The subarachnoid space is continuous with the Virchow-Robin peri-arterial and peri-vascular spaces which surround the arteries and veins that penetrate into the neural tissue, respectively. The dural lymphatic vessels exit the cranial vault via an anterior and a posterior route and eventually drain into the deep cervical lymph nodes. Aided by the presence of aquaporin 4 on the perivascular endfeet of astrocytes, nutrients and other molecules enter the brain from peri-arterial spaces and form interstitial fluid (ISF) that baths neurons and glia before being released into peri-venous spaces. Melatonin, a pineal-derived secretory product which is in much higher concentration in the CSF than in the blood, is believed to follow this route and to clear waste products such as amyloid-β from the interstitial space. The clearance of amyloid-β reportedly occurs especially during slow wave sleep which happens concurrently with highest CSF levels of melatonin. Experimentally, exogenously-administered melatonin defers amyloid-β buildup in the brain of animals and causes its accumulation in the cervical lymph nodes. Clinically, with increased age CSF melatonin levels decrease markedly, co-incident with neurodegeneration and dementia. Collectively, these findings suggest a potential association between the loss of melatonin, decreased glymphatic drainage and neurocognitive decline in the elderly.
Mediated Communication and Customer Service Experiences
Authors: Mays Kate K. , Katz James E. , Groshek Jacob 
Published: December 2021

People around the world who seek to interact with large organisations increasingly find they must do so via mediated and automated communication. Organisations often deploy both mediated and automated platforms, such as instant messaging and interactive voice response systems (IVRs), for efficiency and cost-savings. Customer and client responses to these systems range from delight to frustration. To better understand the factors affecting people's satisfaction with these systems, we conducted a representative U.S. national survey (N = 1321). We found that people overwhelmingly like and trust in-person customer service compared to mediated and automated modalities. As to demographic attitude predictors, age was important (older respondents liked mediated systems less), but income and education were not strong attitude predictors. For personality variables, innovativeness was positively associated with mediated system satisfaction. However, communication apprehensiveness, which we expected to be related to satisfaction, was not. We conclude by discussing implications for the burgeoning field of human-machine communication, as well as social policy, equity, and the pullulating digital services divide.
HMGB3 is Associated With an Unfavorable Prognosis of Neuroblastoma and Promotes Tumor Progression by Mediating TPX2
Authors: Zhong Xiaodan , Zhang Songling , Zhang Yutong , Jiang Zongmiao , Li Yanan , Chang Jian , Niu Junqi , Shi Ying 
Published: December 2021

Neuroblastoma (NB) is the most common solid tumor apart from central nervous system malignancies in children aged 0–14 years, and the outcomes of high-risk patients are dismal. High mobility group box 3 (HMGB3) plays an oncogenic role in many cancers; however, its biological role in NB is still unclear. Using data mining, we found that HMGB3 expression was markedly elevated in NB patients with unfavorable prognoses. When HMGB3 expression in NB cell lines was inhibited, cell proliferation, migration, and invasion were suppressed, and HMGB3 knockdown inhibited NB tumor development in mice. RT−PCR was employed to detect mRNA expression of nine coexpressed genes in response to HMGB3 knockdown, and TPX2 was identified. Furthermore, overexpression of TPX2 reversed the cell proliferation effect of HMGB3 silencing. Multivariate Cox regression analysis indicated that HMGB3 and TPX2 might be independent prognostic factors for overall survival and event-free survival, which showed the highest significance (p &lt; 0.001). According to the nomogram predictor constructed, the integration of gene expression and clinicopathological features exhibited better prognostic prediction power. Furthermore, the random forest algorithm and receiver operating characteristic curves also showed that HMGB3 and TPX2 played important roles in discriminating the vital status (alive/dead) of patients in the NB datasets. Our informatics analysis and biological experiments suggested that HMGB3 is correlated with the unfavorable clinical outcomes of NB, and plays an important role in promoting cell growth, proliferation, and invasion in NB, potentially representing a new therapeutic target for tumor progression.
Epidemiological Aspects, Prenatal Screening and Diagnosis of Congenital Heart Defects in Beijing
Authors: Zhang Yanchun , Zhang Wen , Xu Hongyan , Liu Kaibo 
Published: December 2021

Background: In China, congenital heart disease (CHD) is the most common birth defect type, with approximately 13,000 new cases annually. This study aimed to investigate high-risk factors, prenatal screening and prenatal diagnosis as a basis for clinical decisions.Methods: All CHD cases identified from 2018 to 2020 were obtained from the Beijing city birth defect surveillance system and prenatal diagnosis institutions. The prenatal CHD diagnosis was confirmed by fetal echocardiography and amniotic fluid or cord blood genetic examination. Chi-square, odds ratio (OR), 95% confidence interval (CI), and univariate and multivariate logistic analyses were used to explore the high-risk factors, prenatal screening and prenatal diagnosis of CHD. Results: In total, 6,786/594,860 fetuses with CHD were diagnosed by prenatal echocardiography. The average incidence of CHD was 11.4 per 1,000 births, with an increase of 30.7 per 1,000 births from 2018 to 2020 (P &lt; 0.05); the average incidence of complex CHD (CCHD) was 2.02 per 1,000 births, with no significant change from 2018 to 2020 (P &gt; 0.05). Women age ≥35 years (OR 1.06, 95% CI 0.77–1.46) was at higher risk of having babies with CHD than women aged 21–34 years. Overall, CHD incidence increased with maternal age (OR1.03, 95% CI 1.02–1.03). Additionally, women who had a non-local household registration (OR 1.16, 95% CI 1.10–1.22) or had diabetes mellitus (DM) (OR 1.16, 95% CI 0.96–1.25) were at higher risk of CHD. As an independent factor, CCHD was related to maternal age, DM, fetal gender, and maternal education level (all P &lt; 0.05). The prenatal ultrasound screening detection rate of CCHD was 97.59%, which was far higher than that of total CHD (51.67%) (P &lt; 0.001). The prenatal ultrasound diagnosis rate of CCHD was higher than that of simple CHD (P &lt; 0.001), but the coincidence rate in the ultrasound diagnosis of CCHD was lower than that of simple CHD (P &lt; 0.001). Prenatal genetic testing revealed chromosomal abnormalities in 25.62% (279/1089) of CHD cases with indications for a prenatal diagnosis.Conclusions: Maternal age, household registration and DM were related to CHD occurrence. Prenatal ultrasound screening is a highly effective method for CCHD diagnosis, and CHD fetuses should be closely evaluated to exclude chromosomal abnormalities.
Combining Polygenic Risk Score and Voice Features to Detect Major Depressive Disorders
Authors: Di Yazheng , Wang Jingying , Liu Xiaoqian , Zhu Tingshao 
Published: December 2021

Background: The application of polygenic risk scores (PRSs) in major depressive disorder (MDD) detection is constrained by its simplicity and uncertainty. One promising way to further extend its usability is fusion with other biomarkers. This study constructed an MDD biomarker by combining the PRS and voice features and evaluated their ability based on large clinical samples.Methods: We collected genome-wide sequences and utterances edited from clinical interview speech records from 3,580 women with recurrent MDD and 4,016 healthy people. Then, we constructed PRS as a gene biomarker by p value-based clumping and thresholding and extracted voice features using the i-vector method. Using logistic regression, we compared the ability of gene or voice biomarkers with the ability of both in combination for MDD detection. We also tested more machine learning models to further improve the detection capability.Results: With a p-value threshold of 0.005, the combined biomarker improved the area under the receiver operating characteristic curve (AUC) by 9.09% compared to that of genes only and 6.73% compared to that of voice only. Multilayer perceptron can further heighten the AUC by 3.6% compared to logistic regression, while support vector machine and random forests showed no better performance.Conclusion: The addition of voice biomarkers to genes can effectively improve the ability to detect MDD. The combination of PRS and voice biomarkers in MDD detection is feasible. This study provides a foundation for exploring the clinical application of genetic and voice biomarkers in the diagnosis of MDD.
Increased Plasma Heparanase Activity and Endothelial Glycocalyx Degradation in Dengue Patients Is Associated With Plasma Leakage
Authors: Buijsers Baranca , Garishah Fadel Muhammad , Riswari Silvita Fitri , van Ast Rosalie M. , Pramudo Setyo Gundi , Tunjungputri Rahajeng N. , Overheul Gijs J. , van Rij Ronald P. , van der Ven André , Alisjahbana Bachti , Gasem Muhammad Hussein , de Mast Quirijn , van der Vlag Johan 
Published: December 2021

BackgroundEndothelial hyper-permeability with plasma leakage and thrombocytopenia are predominant features of severe dengue virus infection. It is well established that heparanase, the endothelial glycocalyx degrading enzyme, plays a major role in various diseases with vascular leakage. It is yet to be elucidated whether heparanase activity plays a major role in dengue-associated plasma leakage. Moreover, the major source of heparanase secretion and activation in dengue remains elusive. Since a relatively high amount of heparanase is stored in platelets, we postulate that heparanase released by activated platelets contributes to the increased plasma heparanase activity during dengue virus infection.MethodsHeparanase activity (plasma and urine), and heparan sulfate and syndecan-1 (plasma levels) were measured in dengue patients with thrombocytopenia in acute phase (n=30), during course of disease (n=10) and in convalescent phase (n=25). Associations with clinical parameters and plasma leakage markers were explored. Platelets from healthy donors were stimulated with dengue non-structural protein-1, DENV2 virus and thrombin to evaluate heparanase release and activity ex vivo.ResultsHeparanase activity was elevated in acute dengue and normalized during convalescence. Similarly, glycocalyx components, such as heparan sulfate and syndecan-1, were increased in acute dengue and restored during convalescence. Increased heparanase activity correlated with the endothelial dysfunction markers heparan sulfate and syndecan-1, as well as clinical markers of plasma leakage such as ascites, hematocrit concentration and gall-bladder wall thickening. Notably, platelet number inversely correlated with heparanase activity. Ex vivo incubation of platelets with thrombin and live DENV2 virus, but not dengue virus-2-derived non-structural protein 1 induced heparanase release from platelets.ConclusionTaken together, our findings suggest that the increase of heparanase activity in dengue patients is associated with endothelial glycocalyx degradation and plasma leakage. Furthermore, thrombin or DENV2 activated platelets may be considered as a potential source of heparanase.
Different Effects of Biologics on Systemic Bone Loss Protection in Rheumatoid Arthritis: An Interim Analysis of a Three-Year Longitudinal Cohort Study
Authors: Chen Ming-Han , Yu Shan-Fu , Chen Jia-Feng , Chen Wei-Sheng , Liou The-Ling , Chou Chung-Tei , Hsu Chung-Yuan , Lai Han-Ming , Chen Ying-Chou , Tsai Chang-Youh , Cheng Tien-Tsai 
Published: December 2021

ObjectiveTo compare changes in bone mineral density (BMD) in rheumatoid arthritis (RA) patients receiving three-year conventional synthetic disease-modifying anti-rheumatic drugs (csDMARD), tumor necrosis factor-α inhibitors (TNFi), and abatacept.MethodsPatients with RA were recruited from September 2014 to February 2021. Dual-energy X-ray absorptiometry was used to measure BMD at the femoral neck (FN), total hip (TH), and lumbar spine (L1-4) at enrollment and three years later. Changes in the BMD of each regimen group were analyzed. Multiple ordinary least squares regression was used with the dependent variables to develop a model to predict the change in BMD.ResultsA total of 752 participants were enrolled and 485 completed the three-year follow-up period. Of these, 375 (Group I), 84 (Group II), and 26 (Group III) participants received csDMARDs, TNFi, and abatacept therapy, respectively. Considering both type of therapy and completion of the follow-up period, participants were divided into groups A (csDMARDs, n = 104), B (TNFi, n = 52), and C (abatacept, n = 26). Compared to baseline, BMD decreased significantly at FN (p = 0.003) and L1-4 (p = 0.002) in Group A and at L1-4 (p = 0.005) in Group B, but remained stable at all sites in Group C. In terms of regression-adjusted percent change in BMD, there was a significant difference seen at all measured sites between group C compared to both groups A and B (+0.8%, -2.7%, -1.8% at FN; +0.5%, -1.1%, -1.0% at TH; +0.8%, -2.0%, -3.5% at L1-4, respectively; all p &lt; 0.05). Anti-osteoporosis therapy had a BMD-preserving effect in RA.ConclusionCompared with csDMARDs and TNFi, abatacept may have a better BMD-preserving effect in RA. Anti-osteoporosis therapy can prevent systemic bone loss irrespective of RA therapy.
Single-Dose 13-Valent Conjugate Pneumococcal Vaccine in People Living With HIV – Immunological Response and Protection
Authors: Romaru Juliette , Bahuaud Mathilde , Lejeune Gauthier , Hentzien Maxime , Berger Jean-Luc , Robbins Ailsa , Lebrun Delphine , N’Guyen Yohan , Bani-Sadr Firouzé , Batteux Frédéric , Servettaz Amélie 
Published: December 2021

BackgroundPatients living with HIV (PLHIV) are prone to invasive pneumococcal disease. The 13-valent conjugated pneumococcal vaccine (PCV13) is currently recommended for all PLHIV, followed in most guidelines by a 23-valent polysaccharide pneumococcal vaccine. Data are scarce concerning the immunological efficacy of PCV13 among PLHIV.ObjectiveTo assess the immunological response at one month, and the immunological protection at 1-, 6-, and 12 months in PLHIV with a CD4 cell count above 200 cells/µl after a single dose of PCV13, as measured by both ELISA and opsonophagocytic assay (OPA).MethodsPLHIV with CD4 cell count &gt;200 cells/µl were included. Specific IgG serum concentrations for eight serotypes by ELISA and seven serotypes by OPA were measured at baseline, 1-, 6-, and 12 months after the PCV13 vaccination. Global response was defined as a two-fold increase from baseline of specific IgG antibody levels (μg/ml) assayed by ELISA or as a four-fold increase in OPA titer from baseline, for at least five serotypes targeted by PCV13. Global protection was defined as an IgG-concentration ≥1 µg/ml by ELISA or as an opsonization titer ≥LLOQ by OPA for at least five tested serotypes targeted by PCV13. Factors associated with global response and global protection were assessed using logistic regression.ResultsOf the 38 PLHIV included, 57.9% and 63.2% were global responders, 92.1% and 78.9% were globally protected at one month, and 64.7% and 55.9% were still protected at 12 months, by ELISA and OPA respectively. A CD4/CD8 ratio of &gt;0.8 was significantly associated with a better global response by OPA (OR=6.11, p=0.02), and a CD4 nadir &lt;200 was significantly associated with a poorer global response by ELISA (OR=0.22, p=0.04). A CD4 cell count nadir &lt;200 and age over 50 years were associated with poorer global protection by OPA at M1 (OR=0.18, p=0.04) and M12 (OR= 0.15, p=0.02), respectively. Plasma HIV RNA viral load &lt;40 copies/ml was significantly associated with a better global protection at M1 by ELISA and OPA (OR=21.33, p=0.025 and OR=8.40, p=0.04)ConclusionVaccination with PCV13 in these patients induced immunological response and protection at one month. At one year, more than half of patients were still immunologically protected.