bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data-Driven Feedforward Control Design and Input Shaping Techniques for Multi Actuator Drives
Authors: Shah Prateek , Horowitz Roberto 
Published: January 2021

Abstract
The multi actuator drive technology was unveiled by Seagate in December 2017, a breakthrough that can almost double the data performance of the future generation hard disk drives. This technology will equip drives with dual actuators operating on the same pivot point. Each actuator will control half of the drive’s arms. Since two actuators operate independently on the same pivot timber, the control forces and torques generated by one actuator can affect the operation of the other actuator. We will have a scenario when one actuator is track seeking and the other actuator is in the track following mode. The track seeking actuator will impart vibration disturbances to the track following actuator. Previously, we presented a single-input single-output (SISO) data-driven feedforward control design method (Shah and Horowitz, 2019. “Active Vibration Rejection in Multi Actuator Drives: Data Driven Approach,” Dynamic Systems and Control Conference, Vol. 3) to obtain feedforward controllers for the voice coil motor (VCM) and the micro actuator sequentially. The design was based on multiple frequency response measurements of the actuators. In this paper, first, we present a single-input multi-output (SIMO) data-driven feedforward control design technique to simultaneously obtain feedforward controllers for the VCM and the micro actuator. This methodology will obtain a common controller for multiple drives. We will compare the performance of this algorithm with the sequential SISO design technique (Shah and Horowitz, 2019. “Active Vibration Rejection in Multi Actuator Drives: Data Driven Approach,” Dynamic Systems and Control Conference, Vol. 3). Second, we present an add-on input shaping technique to suppress the residual vibration.
Intensity of Leisure-Time Physical Activity and Dimensions of Mental Well-Being: A Reciprocal Approach Using Parallel Latent Growth Curve Modeling
Authors: Kim Changwook , Kim Jinwon , Thapa Brijesh 
Published: January 2021

Background: The examination of the longitudinal effect of leisure-time physical activity (LTPA) on mental well-being is important, but previous studies have typically been limited by their use of a cross-sectional approach. This study empirically examined how LTPA intensity was associated with changes in distinct functions of mental well-being (eg, emotional, psychological, social) over time, and vice versa. Methods: Parallel latent growth curve modeling in combination with propensity score matching analysis was conducted. Data were derived from a sample of adults from the Midlife in the United States (MIDUS) study. Results: The results showed that the initial level of moderate LTPA at the baseline was associated with growth in psychological and social functioning over time, and vice versa. However, vigorous LTPA at the baseline was related only to growth in emotional functioning over time. Conclusion: The longitudinal association between LTPA and mental well-being had different matching mechanisms for LTPA intensities and their relation to distinct functioning for mental well-being. The findings contribute to an enhanced understanding of LTPA’s longitudinal effect on mental well-being.
Textural and geochemical window into the IDDP-1 rhyolitic melt, Krafla, Iceland, and its reaction to drilling
Authors: Saubin E. , Kennedy B. , Tuffen H. , Nichols A.R.L. , Villeneuve M. , Bindeman I. , Mortensen A. , Schipper C.I. , Wadsworth F.B. , Watson T. , Zierenberg R. 
Published: January 2021

Abstract
The unexpected intersection of rhyolitic magma and retrieval of quenched glass particles at the Iceland Deep Drilling Project-1 geothermal well in 2009 at Krafla, Iceland, provide unprecedented opportunities to characterize the genesis, storage, and behavior of subsurface silicic magma. In this study, we analyzed the complete time series of glass particles retrieved after magma was intersected, in terms of distribution, chemistry, and vesicle textures.
Detailed analysis of the particles revealed them to represent bimodal rhyolitic magma compositions and textures. Early-retrieved clear vesicular glass has higher SiO2, crystal, and vesicle contents than later-retrieved dense brown glass. The vesicle size and distribution of the brown glass also reveal several vesicle populations. The glass particles vary in δD from −120‰ to −80‰ and have dissolved water contents spanning 1.3−2 wt%, although the majority of glass particles exhibit a narrower range. Vesicular textures indicate that volatile overpressure release predominantly occurred prior to late-stage magma ascent, and we infer that vesiculation occurred in response to drilling-induced decompression. The textures and chemistry of the rhyolitic glasses are consistent with variable partial melting of host felsite. The drilling recovery sequence indicates that the clear magma (lower degree partial melt) overlays the brown magma (higher degree partial melt). The isotopes and water species support high temperature hydration of these partial melts by a mixed meteoric and magmatic composition fluid. The textural evidence for partial melting and lack of crystallization imply that magma production is ongoing, and the growing magma body thus has a high potential for geothermal energy extraction.
In summary, transfer of heat and fluids into felsite triggered variable degrees of felsite partial melting and produced a hydrated rhyolite magma with chemical and textural heterogeneities that were then enhanced by drilling perturbations. Such partial melting could occur extensively in the crust above magma chambers, where complex intrusive systems can form and supply the heat and fluids required to re-melt the host rock. Our findings emphasize the need for higher resolution geophysical monitoring of restless calderas both for hazard assessment and geothermal prospecting. We also provide insight into how shallow silicic magma reacts to drilling, which could be key to future exploration of the use of magma bodies in geothermal energy.
Societal costs of chemotherapy in the UK: an incidence-based cost-of-illness model for early breast cancer
Authors: Parsekar Krishnali , Howard Wilsher Stephanie , Sweeting Anna , Patel Anita , Fordham Richard 
Published: January 2021

AimTo estimate annual societal costs associated with chemotherapy for early breast cancer in the UK.DesignMixed methods: (a) an incidence-based cost-of-illness model was developed of indirect costs in patients with breast cancer and carers, and estimated from diagnosis through active treatment until death; (b) interviews with stakeholders were also undertaken to understand actual experiences and impacts of these costs.Data sourcesModel data were collated from relevant national data sources covering general population statistics, UK cancer registries, clinical guidelines and published literature, and patient survey data. Patient and staff views were collected through semistructured interviews.ParticipantsModel: patients with early breast cancer receiving systemic anticancer therapy in the UK. Interviews were undertaken with women who had chemotherapy and medical practitioners involved in breast cancer care.ResultsTotal costs of chemotherapy in the UK economy are over £248 million. Societal productivity losses amount to £141.4 million, which includes £3.2 million associated with premature mortality, short-term and long-term work absence (£28.6 million and £105 million, respectively). £3.4 million is associated with mortality losses from secondary malignancies due to adjuvant chemotherapy. A further £1.1 million in lost productivity arises from informal care provision. Out-of-pocket costs per round of chemotherapy account for £4.2 million, or an annual average of almost £1100 per patient. Interview findings support the cost burden modelled and also highlight the impact on cognitive function of patients and how this could increase the cost burden to patients, their families and wider society. In addition, estimated costs for carer emotional well-being are £82 million in lost quality of life.ConclusionChemotherapy use carries significant indirect costs for society, as well as patients and their carers. These wider costs and societal perspective should be considered by commissioners to ensure chemotherapy is better targeted at those who most need it and to avoid placing unnecessary costs on patients, their caregivers and wider society.
Effects of muscle sympathetic burst size and burst pattern on time-to-peak sympathetic transduction
Authors: Nardone Massimo , Incognito Anthony V. , Teixeira André L. , Cacoilo Joseph A. , Vianna Lauro C. , Millar Philip J. 
Published: January 2021

The current study evaluated the influence of resting muscle sympathetic nerve activity (MSNA) burst size and firing pattern on time-to-peak sympathetic transduction in 36 young healthy men and women. Participants underwent a 5–10 min resting baseline with beat-to-beat measures of heart rate, mean arterial pressure (MAP), and MSNA (microneurography). Cardiac output and total vascular conductance were calculated using the Modelflow algorithm. Sympathetic transduction was quantified using the burst-triggered signal averaging technique to examine the changes in MAP, cardiac output, and total vascular conductance for 15 cardiac cycles after each MSNA burst or non-burst. A stepwise increase in the peak MAP (i.e., sympathetic transduction) was observed throughout all quartiles of normalized MSNA burst area (quartile 1 (Q1): 1.7 ± 1.3 mm Hg; Q2: 2.1 ± 1.3 mm Hg; Q3: 2.6 ± 1.4 mm Hg; Q4: 3.5 ± 1.4 mm Hg; P < 0.01). The largest quartile of normalized MSNA burst area demonstrated faster time-to-peak MAP responses (5.7 ± 2.5 s) than both Q1 (10.1 ± 3.9 s, P < 0.01) and Q2 (9.3 ± 4.1 s, P < 0.01), as well as, faster time-to-peak cardiac output and time-to-nadir total vascular conductance compared with Q1 and Q2 (All P < 0.05). Larger clusters of sympathetic bursts (i.e., triplets and ≥ quadruplets) did not have increased time-to-peak transduction compared with singlets and doublet bursts across all MSNA quartiles. These results highlight intraindividual variability in the time-course of sympathetic transduction and reveal an intrinsic property of larger sympathetic bursts to increase time-to-peak sympathetic transduction in humans. Novelty: Muscle sympathetic burst size can modulate time-to-peak sympathetic transduction in young healthy men and women. These observations appear independent of the pattern of sympathetic firing.
A study of $$\varLambda $$ and $$\bar{\varLambda }$$ polarization splitting by meson field in PICR hydrodynamic model
Authors: Xie Yilong , Chen Gang , Csernai Laszlo Pal 
Published: January 2021

AbstractWith the PICR hydrodynamic model, we study the polarization splitting between $$\varLambda $$
Λ
and $$\bar{\varLambda }$$

Λ

¯

at RHIC BES energy range, based on the meson field mechanism. Our results fit to the experimental data fairly well. Besides, two unexpected effect emerges: (1) the baryon density gradient has non-trivial and negative contribution to the polarization splitting; (2) for 7.7 GeV Au+Au collisions within the centrality range of 20–50%, the polarization splitting surprisingly increases with the centrality decreases. The second effect might help to explain the significant signal of polarization splitting measured in STAR’s Au+Au 7.7 Gev collisions.
Two quantum private query protocols based on Bell states and single photons
Authors: Liu Dong-Mei , Yan Li-Li , Chang Yan , Zhang Shi-Bin , Cao Tian 
Published: January 2021

This paper proposes two quantum privacy query protocols. In the single vector sub-privacy query of protocol 1, it is proposed for the first time to distinguish different measurement results by publishing 2 bits of classic information. In the protocol, the database Bob selects the Z base and the Bell base to measure the particles sent by Alice according to the key value of the encrypted database and publishes 2 bits of classic information based on the measurement results. The user Alice infers the key value of the encrypted database through these two pieces of classic information. In the two-way quantum privacy query of protocol 2, the database Bob measures the particles sent back by Alice, converts the measurement result into a key value of length 3, and prepares a particle that is the same as the measurement result and sends it back to Alice. Alice returns the measurement of particles can infer a set of data encryption keys, and the length of each key is 3 bits. Users in the two protocols proposed in the article can obtain the query key with a probability of 1/4. As the key length increases, the number of query bits in protocol 2 decreases, but the probability of execution failure increases. But protocol 2 has a higher quantum efficiency. Both protocols can guarantee the privacy of users and databases.
Introduction: geoethics goes beyond the geoscience profession
Authors: Di Capua Giuseppe , Bobrowsky Peter T. , Kieffer Susan W. , Palinkas Cindy 
Published: January 2021

Abstract
This is the second volume focused on geoethics published as a Special Publication of the Geological Society of London, a significant step forward in which authors address the maturation of geoethics, a maturity that has strengthened its theoretical foundations in recent years and increased the insight of its reflections. The field of geoethics is now ready to be introduced outside the geoscience community as a logical platform for global ethics that addresses anthropogenic changes. What is clear is that geoethics has a distinction in the geoscientific community for discussing the ethical, social and cultural implications of geoscience knowledge, research, practice and education, as well as communication. This provides a common ground for integrating ideas, experiences and proposals on how geosciences can provide additional services to society, in order to improve the way humans interact responsibly with the Earth system. This book provides new messages to geoscientists, social scientists, intellectuals, law- and decision-makers, and laypeople. Motivations and actions for facing global anthropogenic changes and their intense impacts on the planet need to be governed by an ethical framework capable of merging a solid conceptual structure with pragmatic approaches based on geoscientific knowledge. This philosophy defines geoethics.
Pharmacological Treatment of Severe Breathing Abnormalities in a Case of HNRNPU Epileptic Encephalopathy
Authors: Spagnoli Carlotta , Rizzi Susanna , Salerno Grazia Gabriella , Frattini Daniele , Koskenvuo Juha , Fusco Carlo 
Published: January 2021

Abnormal breathing patterns are a typical feature of Rett and Pitt-Hopkins syndrome and their variants. Their treatment can be challenging, with a risk of long-term detrimental consequences. Early infantile epileptic encephalopathy (EIEE) type 54 is a rare epileptic encephalopathy caused by pathogenic variants in the heterogeneous nuclear ribonucleoprotein U (HNRNPU) gene. Only one case has been described in the literature with episodes of hyperventilation and apnea, but treatment was not discussed. We describe the clinical and genetic features and treatment strategies in a case of EIEE type 54 and severely abnormal breathing pattern. A novel and likely pathogenic c.2277dup, p.(Pro760Serfs*5) variant in the HNRNPU gene was found in a male patient with severe episodes of hyperventilation and apnea, leading to syncope. Combination therapy with acetazolamide, alprazolam and aripiprazole led to significant clinical improvement. Although HNRNPU has not been implicated in breathing control, pathogenic variants in this gene can be associated with the development of abnormal breathing patterns reminiscent of Rett and Pitt-Hopkins syndrome. Its function as a gene expression regulator and its interaction with transcription factors offers a potential pathogenetic link between these 3 disorders. Based on our experience, treatment strategies can be similar to those already applied for patients with Pitt-Hopkins and Rett syndrome.
Body Mass Index and Clinical Outcomes in Asian Patients With Atrial Fibrillation Receiving Oral Anticoagulation
Authors: Lee So-Ryoung , Choi Eue-Keun , Jung Jin-Hyung , Park Sang-Hyun , Han Kyung-Do , Oh Seil , Lip Gregory Y.H. 
Published: January 2021

Background and Purpose:
The influence of body mass index (BMI) on clinical outcomes in patients with atrial fibrillation remains controversial, especially among Asians. We aimed to evaluate the association between BMI and clinical outcomes in Asian patients with atrial fibrillation receiving oral anticoagulants.

Methods:
Using the Korean National Health Insurance database between January 2015 and December 2017, we identified oral anticoagulant new users among patients with nonvalvular atrial fibrillation who had BMI information. We analyzed ischemic stroke, intracranial hemorrhage, hospitalization for gastrointestinal bleeding, major bleeding, all-cause death, and the composite clinical outcome according to BMI categories.

Results:

A total of 43 173 patients were included across BMI categories (kg/m
2
): underweight (<18.5) in 3%, normal (18.5 to <23) in 28%, overweight (23 to <25) in 24%, obese I (25 to <30) in 39%, and obese II (≥30) in 6%. Higher BMI (per 5 kg/m
2
increase) was significantly associated with lower risks of ischemic stroke (hazard ratio [HR], 0.891 [95% CI, 0.801–0.992]), hospitalization for gastrointestinal bleeding (HR, 0.785 [95% CI, 0.658–0.937]), major bleeding (HR, 0.794 [95% CI, 0.686–0.919]), all-cause death (HR, 0.658 [95% CI, 0.605–0.716]), and the composite clinical outcome (HR, 0.751 [95% CI, 0.706–0.799]), except for intracranial hemorrhage (HR, 0.815 [95% CI, 0.627–1.061]). The underweight group was associated with an increased risk of composite clinical outcome (HR, 1.398 [95% CI, 1.170–1.671]), mainly driven by an increased risk of all-cause death. The effects of non–vitamin K antagonist oral anticoagulant versus warfarin on clinical outcomes were similar across BMI groups.

Conclusions:
Higher BMI was independently associated with a lower risk of ischemic stroke, major bleeding, and better survival. Underweight patients had a higher risk of all-cause death and composite clinical outcome. The optimal BMI for patients with atrial fibrillation should be defined and managed according to an integrated care pathway.
Associations of an Abnormal Physiological Score With Outcomes in Acute Intracerebral Hemorrhage
Authors: Song Lili , Wang Xia , Ouyang Menglu , Sun Lingli , Chen Xiaoying , Arima Hisatomi , Sandset Else C. , Delcourt Candice , Wang Jiguang , Chen Guofang , Robinson Thompson , Lindley Richard I. , Chalmers John , Anderson Craig S. ,   for the INTERACT2 Investigators
Published: January 2021

Background and Purpose:
We determined associations of physiological abnormalities (systolic blood pressure, glucose, and body temperature) and warfarin use with outcomes in spontaneous intracerebral hemorrhage.

Methods:
Post hoc analyses of INTERACT2 (Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial) comparing systolic blood pressure control (<140 versus <180 mm Hg) in 2839 hypertensive patients with intracerebral hemorrhage (onset <6 hours). Multivariable logistic regression defined associations of baseline scores assigned as 0 to 6 per 10 mm Hg systolic blood pressure increase (range, 150–220 mm Hg) and 0 or 1 for serum glucose (≤6.5 versus >6.5 mmol/L), body temperature (≤37.5 °C versus >37.5 °C), and warfarin use (no versus yes) and death or major disability (modified Rankin Scale scores 3–6 at 90 days).

Results:
Baseline score distribution was 0 (7.7%), 1 (15.6%), 2 (19.0%), 3 (19.1%), 4 (15.2%), 5 (11.6%), 6 (8.9%), and 7 (2.9%). After adjustment for baseline neurological severity and potential confounders, significant linear associations were evident for increasing (per point) score and death or major disability (odds ratio, 1.12 [95% CI, 1.07–1.17]), death (odds ratio, 1.15 [95% CI, 1.07–1.23]), and major disability (odds ratio, 1.10 [95% CI, 1.05–1.15]).

Conclusions:
Combination of abnormal physiological parameters and warfarin use is associated with poor outcomes in intracerebral hemorrhage. Effects of their early control is under investigation in INTERACT3 (Intensive Care Bundle With Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial).

Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT00716079.
Cost-Effectiveness of Mechanical Thrombectomy for Treatment of Nonminor Ischemic Stroke Across Europe
Authors: Candio Paolo , Violato Mara , Leal Jose , Luengo-Fernandez Ramon 
Published: January 2021

Background and Purpose:
Mechanical thrombectomy (MT) has been recommended for the treatment of nonminor ischemic stroke by national and international guidelines, but cost-effectiveness evidence has been generated for only a few countries using heterogeneous evaluation methods. We estimate the cost-effectiveness of MT across 32 European countries.

Methods:
A Markov model was developed to estimate the cost-effectiveness of MT compared with standard care over a 5-year time horizon. Patients with ischemic stroke eligible for MT were identified from 2017 country-specific incidence data. A societal perspective was adopted, including health, social, and informal care costs, and productivity losses. Model outcomes were expressed as quality-adjusted life years. Sensitivity analyses were conducted to test the robustness of findings.

Results:
We identified 267 514 ischemic stroke cases that were eligible for MT treatment across 32 European countries. MT was found to be more effective and cheaper than standard care in two-thirds of the countries (21/32) and cost-effective in all but one country (Bulgaria). Across Europe, the intervention was estimated to produce over 101 327 additional quality-adjusted life years (95% uncertainty interval, 65 180–149 085) and cost savings of $981 million (€868 million, 95% uncertainty interval, −1544 to 2564) and of $1.7 billion (€1.5 billion, 95% uncertainty interval, −1.2 to 3.6) in health and social care and societal costs, respectively.

Conclusions:
MT is highly likely to be cost-effective compared with standard care across Europe as a whole and in the vast majority of European countries.