bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women’s Magazines: The Pursuit of Pleasure and Politics
Authors: Andrews Maggie , Carter Fan 
Published: September 2021

This chapter charts the development of the women’s magazine market in the twentieth century. It argues that while commercial magazines are principally leisure purchases shaped by the expectations of industry and advertisers, they are also spaces where sifting and contested ideas of femininity are worked through. Focusing on two moments of significant social and political change for women, the chapter explores the ways that magazines navigated discourses of feminism and political citizenship alongside familiar tropes of consumer femininity. In the interwar years politicians initially courted newly enfranchised women, and magazines sought to encourage women’s political engagement through a mobilisation of the term 'housewife'. Additionally, an examination of the young women's magazine Honey sheds light on the 1960s and 1970s when both the youth movements and women's liberation came to prominence.
The Sound of Protest: Acousmatic Resistance in El Método
Authors: López Lerma Mónica 
Published: September 2021

Drawing on the works of Henri Lefebvre and Chris Butler, chapter four explores the relationship between justice, aesthetics, and (the right to) the city through the 2012 Spanish film Grupo 7 directed by Alberto Rodríguez. Based on real events, the film follows a police unit tasked with cleansing the touristy downtown of Seville of prostitution and drug trafficking in order to convey an image of modernity for the Universal Exposition of 1992. By inviting viewers to experience the violent transformation of Seville, the film makes visible pervasive forms of violence (crime, police brutality, and corruption) concealed behind the promises of modernity. It exposes the ways in which the state and the law shape the social body, organize relations of power, and distribute the sensory order—meaning who and what are included or excluded and who and what are visible or invisible—in a way that erases difference and diversity. The chapter argues that rather than offering a solution, the film constructs a haptic aesthetic where the city’s suburbs and outskirts, its messiness and noise, generally all brushed off by the logic of progress and modernization, cannot be left out from the viewer’s sensory experience of the city.
Momentary Rupture? Dawn (1928) and the Transgressive Potential of the Edith Cavell Case
Authors: Sternberg Claudia 
Published: September 2021

The chapter establishes the complex web of transgressions that underlie the enduring preoccupation with Edith Cavell, the English nurse and resistance worker who was executed in Belgium by German occupying forces during the First World War. The contribution then offers a close reading of the biographical anti-war film Dawn (dir. Herbert Wilcox, UK 1928) which constitutes a transgressive text in its own right. Politically, this late silent production brings back the Cavell story at a time of public forgetting, provoking instances of censorship and self-censorship. In narrative terms, Dawn subverts cinemagoers’ certainties by introducing a new paradigm to British screens for the depiction of the Great War more generally. Finally, Dawn’s pacifist feminism and humanisation of the enemy, as proposed by writer Reginald Berkeley, are ideological border crossings that attempt to refashion the Cavell myth. By comparing the editing and intertitles of the British and Belgian versions of the film, the chapter concludes that Dawn remains an exception within visual culture and the representation of Cavell and her executioners.
Muybridge’s Disobedient Horses: Non-stop Stop-motion
Authors: Vasof Anna 
Published: September 2021

In this chapter, the media artist Anna Vasof discusses her animation project Non-Stop Stop-Motion, situated at the intersection between video, performance, the fine arts and photography. Non-Stop Stop-Motion is an ongoing practice-based artistic research project, which investigates where we can find the essence of cinematic illusion when we look into everyday life and what happens when we use everyday situations, objects, spaces and actions as cinematographic mechanisms. This question leads to multiple observations of everyday life and experimentation therein.
Feet of strength: the sword-and-sandals film
Authors: Rushing Robert A. 
Published: September 2021

The “sword and sandals” film may be the only cinematic genre named after an article of footwear; called “peplum” films in Europe, these largely Italian, low-budget films of the 1950s and 1960s starred American bodybuilders as iconic strongmen of mythological and Biblical antiquity (Hercules, Samson, Goliath, etc.). The foot plays a largely defensive role in these films (feet and footwear are the most iconic site of the Freudian fetish), with sandals providing a way for the genre to alleviate anxieties for its putatively male adolescent spectators about their immature bodies and their masculinity. At the same time, the genre also flirts with a more haptic kind of openness, a different sort of strength that might emerge from lowering one’s defences and touching the Earth directly—an openness that is almost invariably foreclosed in a genre of anxious and defensive masculinity.
New Imaging Signatures of Cardiac Alterations in Ischaemic Heart Disease and Cerebrovascular Disease Using CMR Radiomics
Authors: Rauseo Elisa , Izquierdo Morcillo Cristian , Raisi-Estabragh Zahra , Gkontra Polyxeni , Aung Nay , Lekadir Karim , Petersen Steffen E. 
Published: September 2021

Background: Ischaemic heart disease (IHD) and cerebrovascular disease are two closely inter-related clinical entities. Cardiovascular magnetic resonance (CMR) radiomics may capture subtle cardiac changes associated with these two diseases providing new insights into the brain-heart interactions.Objective: To define the CMR radiomics signatures for IHD and cerebrovascular disease and study their incremental value for disease discrimination over conventional CMR indices.Methods: We analysed CMR images of UK Biobank's subjects with pre-existing IHD, ischaemic cerebrovascular disease, myocardial infarction (MI), and ischaemic stroke (IS) (n = 779, 267, 525, and 107, respectively). Each disease group was compared with an equal number of healthy controls. We extracted 446 shape, first-order, and texture radiomics features from three regions of interest (right ventricle, left ventricle, and left ventricular myocardium) in end-diastole and end-systole defined from segmentation of short-axis cine images. Systematic feature selection combined with machine learning (ML) algorithms (support vector machine and random forest) and 10-fold cross-validation tests were used to build the radiomics signature for each condition. We compared the discriminatory power achieved by the radiomics signature with conventional indices for each disease group, using the area under the curve (AUC), receiver operating characteristic (ROC) analysis, and paired t-test for statistical significance. A third model combining both radiomics and conventional indices was also evaluated.Results: In all the study groups, radiomics signatures provided a significantly better disease discrimination than conventional indices, as suggested by AUC (IHD:0.82 vs. 0.75; cerebrovascular disease: 0.79 vs. 0.77; MI: 0.87 vs. 0.79, and IS: 0.81 vs. 0.72). Similar results were observed with the combined models. In IHD and MI, LV shape radiomics were dominant. However, in IS and cerebrovascular disease, the combination of shape and intensity-based features improved the disease discrimination. A notable overlap of the radiomics signatures of IHD and cerebrovascular disease was also found.Conclusions: This study demonstrates the potential value of CMR radiomics over conventional indices in detecting subtle cardiac changes associated with chronic ischaemic processes involving the brain and heart, even in the presence of more heterogeneous clinical pictures. Radiomics analysis might also improve our understanding of the complex mechanisms behind the brain-heart interactions during ischaemia.
Mitochondrial Respiration Defects in Single-Ventricle Congenital Heart Disease
Authors: Xu Xinxiu , Lin Jiuann-Huey Ivy , Bais Abha S. , Reynolds Michael John , Tan Tuantuan , Gabriel George C. , Kondos Zoie , Liu Xiaoqin , Shiva Sruti S. , Lo Cecilia W. 
Published: September 2021

Background: Congenital heart disease (CHD) with single-ventricle (SV) physiology is now survivable with a three-stage surgical course ending with Fontan palliation. However, 10-year transplant-free survival remains at 39–50%, with ventricular dysfunction progressing to heart failure (HF) being a common sequela. For SV-CHD patients who develop HF, undergoing the surgical course would not be helpful and could even be detrimental. As HF risk cannot be predicted and metabolic defects have been observed in Ohia SV-CHD mice, we hypothesized that respiratory defects in peripheral blood mononuclear cells (PBMCs) may allow HF risk stratification in SV-CHD.Methods: SV-CHD (n = 20), biventricular CHD (BV-CHD; n = 16), or healthy control subjects (n = 22) were recruited, and PBMC oxygen consumption rate (OCR) was measured using the Seahorse Analyzer. Respiration was similarly measured in Ohia mouse heart tissue.Results: Post-Fontan SV-CHD patients with HF showed higher maximal respiratory capacity (p = 0.004) and respiratory reserve (p &lt; 0.0001), parameters important for cell stress adaptation, while the opposite was found for those without HF (reserve p = 0.037; maximal p = 0.05). This was observed in comparison to BV-CHD or healthy controls. However, respiration did not differ between SV patients pre- and post-Fontan or between pre- or post-Fontan SV-CHD patients and BV-CHD. Reminiscent of these findings, heart tissue from Ohia mice with SV-CHD also showed higher OCR, while those without CHD showed lower OCR.Conclusion: Elevated mitochondrial respiration in PBMCs is correlated with HF in post-Fontan SV-CHD, suggesting that PBMC respiration may have utility for prognosticating HF risk in SV-CHD. Whether elevated respiration may reflect maladaptation to altered hemodynamics in SV-CHD warrants further investigation.
Exhaled Volatile Organic Compounds for Identifying Patients With Chronic Pulmonary Aspergillosis
Authors: Li Zheng-Tu , Zeng Pei-Ying , Chen Zhao-Ming , Guan Wei-Jie , Wang Tong , Lin Ye , Li Shao-Qiang , Zhang Zhi-Juan , Zhan Yang-Qing , Wang Ming-Die , Tan Guo-Bin , Li Xue , Ye Feng 
Published: September 2021

Background: Diagnosing chronic pulmonary aspergillosis is a major challenge in clinical practice. The development and validation of a novel, sensitive and specific assay for diagnosing chronic pulmonary aspergillosis is urgently needed.Methods: From April 2018 to June 2019, 53 patients with chronic pulmonary aspergillosis (CPA), 32 patients with community-acquired pneumonia (CAP) and 48 healthy controls were recruited from the First Affiliated Hospital of Guangzhou Medical University. Clinical characteristics and samples were collected at enrollment. All exhaled breath samples were analyzed offline using thermal desorption single-photon ionization time-of-flight mass spectrometry; to analyze the metabolic pathways of the characteristic volatile organic compounds, serum samples were subjected to ultrahigh-performance liquid chromatography.Results: We identified characteristic volatile organic compounds in patients with chronic pulmonary aspergillosis, which mainly consisted of phenol, neopentyl alcohol, toluene, limonene and ethylbenzene. These compounds were assessed using a logistic regression model. The sensitivity and specificity were 95.8 and 96.9% for discriminating patients in the CPA group from those in the CAP group and 95.8 and 97.9% for discriminating patients in the CPA group from healthy controls, respectively. The concentration of limonene (m/z 136) correlated significantly positively with anti-Aspergillus fumigatus IgG antibody titers (r = 0.420, P &lt; 0.01). After antifungal treatment, serum IgG and the concentration of limonene (m/z 136) decreased in the subgroup of patients with chronic pulmonary aspergillosis.Conclusions: We identified VOCs that can be used as biomarkers for differential diagnosis and therapeutic response prediction in patients with chronic pulmonary aspergillosis.
High Endurance Elite Athletes Show Age-dependent Lower Levels of Circulating Complements Compared to Low/Moderate Endurance Elite Athletes
Authors: Al-Muraikhy Shamma , Ramanjaneya Manjunath , Dömling Alexander S. , Bettahi Ilham , Donati Francesco , Botre Francesco , Abou-Samra Abdul-Badi , Sellami Maha , Elrayess Mohamed A 
Published: September 2021

Introduction: Aerobic exercise activates the complement system in the peripheral blood. However, the effect of age and high intensity endurance training on the levels of circulating complements and sassociated inflammatory cytokines, oxidative stress markers and cellular aging remains unknown.Methods: In this study, serum samples from 79 elite athletes who belong to high (n = 48) and low/moderate (n = 31) endurance sports and two age groups (below 30 years old, n = 53, and above 30 years old, n = 26) were profiled for 14 complements. Linear models were used to assess differences in complements levels between sport and age groups. Spearmann’s correlation was used to assess the relationship among detected complements and proinflammatory cytokines, oxidative stress markers and telomere lengths.Results: High endurance elite athletes exhibited significantly lower levels of circulating C2, C3b/iC3b and adipsin complements than their age-matched low/moderate endurance counterparts. Levels of C2, adipsin and C3b/iC3b were positively correlated with most detected complements, the pro-inflammatory cytokines TNF-alpha and IL-22 and the anti-oxidant enzyme catalase. However, they were negatively correlated with telomere length only in younger elite athletes regardless of their sport groups. Furthermore, high endurance elite athletes showed significantly lower concentrations of C3b/iC3b, C4b, C5, C5a, C1q, C3, C4, factor H and properdin in younger athletes compared to their older counterparts.Conclusion: Our novel data suggest that high endurance elite athletes exhibit age-independent lower levels of circulating C2, C3b/iC3b and adipsin, associated with lower inflammatory, oxidative stress and cellular aging, as well as lower levels of 10 other complements in younger athletes compared to older counterparts. Assessing the effect of various levels of endurance sports on complements-based immune response provides a better understanding of exercise physiology and pathophysiology of elite athletes.
Online Food Frequency Questionnaire From the Cohort of Universities of Minas Gerais (CUME Project, Brazil): Construction, Validity, and Reproducibility
Authors: Azarias Heloísa Gambarelli de Araújo , Marques-Rocha José Luiz , Miranda Aline Elizabeth da Silva , dos Santos Luana Caroline , Gomes Domingos Ana Luíza , Hermsdorff Helen Hermana Miranda , Bressan Josefina , Oliveira Fernando Luiz Pereira de , Leal Arieta Carla Gualandi , Pimenta Adriano Marçal 
Published: September 2021

Background: The Food Frequency Questionnaire (FFQ) is usually used in epidemiological studies to assess food consumption. However, the FFQ must have good accuracy, requiring its validation and reproducibility for the target population. Thus, this study aimed to describe the construction of the online Food Frequency Questionnaire (oFFQ) used at the Cohort of Universities of Minas Gerais (CUME project, Brazil) and evaluate its validity and reproducibility.Methods: The oFFQ was answered two times in 1 year (March/August 2018—March/April 2019; n = 108 participants—reproducibility), and four 24-h dietary recalls (24hRs) were applied in two seasons of the southern hemisphere [two 24hRs in autumn (March/June 2018) and two 24hRs in winter (August/September 2018); n = 146 participants—validity]. To assess the validity and reproducibility, the intraclass correlation coefficients (ICCs) were estimated.Results: The oFFQ had 144 food items separated into eight groups (dairy products; meat and fish; cereals and legumes; fruits; vegetables; fats and oils; drinks; other foods). In assessing the validity, ICCs for energy and macronutrients were considered moderate, ranging from 0.41 (energy) to 0.59 (protein), while the ICCs for micronutrients were considered low to moderate, ranging from 0.25 (fibers) to 0.65 (vitamin B6). Regarding reproducibility assessment, ICCs for energy and all the assessed items were considered moderate to excellent, ranging from 0.60 (vegetables) to 0.91 (vitamin E and retinol).Conclusions: The self-reported oFFQ had satisfactory validity and reproducibility. So, it can be used to analyze the association between food consumption and chronic diseases in the participants of the Cohort of Universities of Minas Gerais (CUME project—Brazil).
Association Between Adjuvant Sorafenib and the Prognosis of Patients With Hepatocellular Carcinoma at a High Risk of Recurrence After Radical Resection
Authors: Li Qingli , Song Tianqiang 
Published: September 2021

BackgroundThe use of sorafenib in the adjuvant management of hepatocellular carcinoma (HCC) is controversial.AimTo analyze the effects of adjuvant sorafenib therapy in patients with HCC at high recurrence risk after radical resection.MethodsThis was a retrospective study of patients who underwent radical resection (R0 resection) for HCC at the Cancer Hospital of Tianjin Medical University between August 2009 and August 2017. All patients had microvascular invasion and were evaluated for portal vein tumor thrombus. The outcomes were overall survival (OS), recurrence-free survival (RFS), and survival after recurrence. Propensity score matching (PSM) was used.ResultsBefore matching, there were 56 and 167 patients in the sorafenib and non-sorafenib groups. After PSM, there were 42 patients/group, and there were no significant differences in patient characteristics (all P&gt;0.05). After PSM, compared with the non-sorafenib group, the sorafenib group showed longer median OS (34 vs. 26 months, P=0.032) and survival after recurrence (16 vs. 9 months, P=0.002), but no difference in RFS (14 vs. 11 months, P=0.564). Adjuvant sorafenib was the only factor independently associated with OS (HR=0.619, 95% CI: 0377–0.994, P=0.047). No factors were independently associated with RFS (all P&gt;0.05).ConclusionAlthough adjuvant sorafenib therapy for patients with HCC and high recurrence risk does not reduce the recurrence risk of HCC, it might be associated with longer survival and a lower risk of death.
Case Report: The Monogenic Familial Steroid-Resistant Nephrotic Syndrome Caused by a Novel Missense Mutation of NPHS2 Gene A593C in a Chinese Family
Authors: Bai Ling , Zhuang Jing , Zhang Changrong , Lu Chen , Tian Xuefei , Jiang Hong 
Published: September 2021

Background: Pathogenic variants in the NPHS2 gene encoding podocin in kidney podocytes are associated with autosomal recessive steroid-resistant nephrotic syndrome (SRNS) by disrupting podocyte function and the integrity of the glomerular filtration barrier. The outcome is generally poor by progressing into end-stage kidney disease (ESKD). With the help of gene diagnostics, we can further understand the role of podocin of podocytes in the development and progression of SRNS. However, the pathological mutation of NPHS2 and clinical relevance remain further elusive.Case Presentation: Two siblings, a 15-year-old girl and her 10-year-old younger brother from a consanguineous Chinese family, presented with nephrotic syndrome. Both of them developed progressive proteinuria starting from the 5-year-old of age. The renal pathological lesions for them revealed focal segmental glomerulosclerosis (FSGS). There was no response to the glucocorticoid, calcineurin inhibitors, and rituximab treatment. The female affected patient received the hemodialysis treatment due to ESKD in June 2020; the male patient was still in follow-up presenting with SRNS. The mutational screening of the two patients and their parents using Trio whole-exome sequencing showed the NPHS2 gene de novo missense mutation in exon 5 (A593C), for which the two siblings were homozygous and their parents confirmed heterozygous asymptomatic carriers. No other SRNS-related gene variants with the SRNS were determined.Conclusion: Pathological gene variants screening in children clinically suspected with SRNS might be helpful in the diagnosis as well as appropriate decisions on treatment strategies and prediction of prognosis.
Association of microRNAs With Embryo Development and Fertilization in Women Undergoing Subfertility Treatments: A Pilot Study
Authors: Butler Alexandra E. , Cunningham Thomas Keith , Ramachandran Vimal , Diboun Ilhame , Halama Anna , Sathyapalan Thozhukat , Najafi-Shoushtari S. Hani , Atkin Stephen L. 
Published: September 2021

Objective: Small non-coding RNAs, known as microRNAs (miRNAs), have emerging regulatory functions within the ovary that have been related to fertility. This study was undertaken to determine if circulating miRNAs reflect the changes associated with the parameters of embryo development and fertilization.Methods: In this cross-sectional pilot study. Plasma miRNAs were collected from 48 sequentially presenting women in the follicular phase prior to commencing in vitro fertilization (IVF). Circulating miRNAs were measured using locked nucleic acid (LNA)-based quantitative PCR (qPCR), while an updated miRNA data set was used to determine their level of expression.Results: Body mass index and weight were associated with the miRNAs let7b-3p and miR-375, respectively (p &lt; 0.05), with the same relationship being found between endometrium thickness at oocyte retrieval and miR-885-5p and miR-34a-5p (p &lt; 0.05). In contrast, miR-1260a was found to be inversely associated with anti-Mullerian hormone (AMH; p = 0.007), while miR-365a-3p, miR122-5p, and miR-34a-5p correlated with embryo fertilization rates (p &lt; 0.05). However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p &lt; 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively). Furthermore, age was negatively associated with miR-335-3p, miR-28-5p, miR-155-5p, miR-501-3p, and miR-497-5p (p &lt; 0.05). Live birth rate was negatively associated with miR-335-3p, miR-100-5p, miR-497-5p, let-7d, and miR-574-3p (p &lt; 0.05), but these were not significant when age was accounted for.However, with the exclusion of male factor infertility, all those miRNAs were no longer significant, though miR.150.5p emerged as significant (p = 0.042). A beta-regression model identified miR-1260a, miR-486-5p, and miR-132-3p (p &lt; 0.03, p = 0.0003, p &lt; 0.00001, respectively) as the most predictive for fertilization rate. Notably, changes in detectable miRNAs were not linked to cleavage rate, top quality embryos (G3D3), and blastocyst or antral follicle count. An ingenuity pathway analysis showed that miRNAs associated with age were also associated with the variables found in reproductive system diseases.Conclusion: Plasma miRNAs prior to the IVF cycle were associated with differing demographic and IVF parameters, including age, and may be predictive biomarkers of fertilization rate.