bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-tracer analysis of straight depolarisation canals in the surroundings of the 3C 196 field
Authors: Turić Luka , Jelić Vibor , Jaspers Rutger , Haverkorn Marijke , Bracco Andrea , Erceg Ana , Ceraj Lana , van Eck Cameron , Zaroubi Saleem 
Published: August 2021

Context. Faraday tomography of a field centred on the extragalactic point source 3C 196 with the LOw Frequency ARray (LOFAR) revealed an intertwined structure of diffuse polarised emission with straight depolarisation canals and tracers of the magnetised and multi-phase interstellar medium (ISM), such as dust and line emission from atomic hydrogen (HI).
Aims. This study aims at extending the multi-tracer analysis of LOFAR data to three additional fields in the surroundings of the 3C 196 field. For the first time, we study the three-dimensional structure of the LOFAR emission by determining the distance to the depolarisation canals.
Methods. We used the rolling Hough transform to compare the orientation of the depolarisation canals with that of the filamentary structure seen in HI, and based on starlight and dust polarisation data, with that of the plane-of-the-sky magnetic field. Stellar parallaxes from Gaia complemented the starlight polarisation with the corresponding distances.
Results. Faraday tomography of the three fields shows a rich network of diffuse polarised emission at Faraday depths between − 10 and + 15 rad m−2. A complex system of straight depolarisation canals resembles that of the 3C 196 field. The depolarisation canals align both with the HI filaments and with the magnetic field probed by dust. The observed alignment suggests that an ordered magnetic field organises the multiphase ISM over a large area (~20°). In one field, two groups of stars at distances below and above 200 pc, respectively, show distinct magnetic field orientations. These are both comparable with the orientations of the depolarisation canals in the same field. We conclude that the depolarisation canals likely trace the same change in the magnetic field as probed by the stars, which corresponds to the edge of the Local Bubble.
The diffuse interstellar band around 8620 Å
Authors: Zhao H. , Schultheis M. , Rojas-Arriagada A. , Recio-Blanco A. , de Laverny P. , Kordopatis G. , Surot F. 
Published: August 2021

Context.Diffuse interstellar bands (DIBs) are important interstellar absorption features of which the origin is still debated. With the large data sets from modern spectroscopic surveys, background stars are widely used to show how the integrated columns of DIB carriers accumulate from the Sun to great distances. To date, studies on the kinematics of the DIB carriers are still rare.Aims.We aim to make use of the measurements from the Giraffe Inner Bulge Survey (GIBS) and theGaia–ESO survey (GES) to study the kinematics and distance of the carrier of DIBλ8620, as well as other properties.Methods.The DIBs were detected and measured following the same procedures as in Zhao et al. (2021, A&A, 645, A14; hereafter Paper I), assuming a Gaussian profile. The median radial velocities of the DIB carriers in 38 GIBS and GES fields were used to trace their kinematics, and the median distances of the carriers in each field were estimated by the median radial velocities and two applied Galactic rotation models.Results.We successfully detected and measured DIBλ8620 in 760 of 4117 GES spectra with |b| ≤ 10° and signal-to-noise ratio (S∕N) > 50. Combined with the DIBs measured in GIBS spectra (Paper I), we confirmed a tight relation between EW andE(J−KS) as well asAV, with similar fitting coefficients to those found by previous works. With a more accurate sample and the consideration of the solar motion, the rest-frame wavelength of DIBλ8620 was redetermined as 8620.83 Å, with a mean fit error of 0.36 Å. We studied the kinematics of the DIB carriers by tracing their median radial velocities in each field in the local standard of rest (VLSR) and into the galactocentric frame (VGC), respectively, as a function of the Galactic longitudes. Based on the medianVLSRand two Galactic rotation models, we obtained valid kinematic distances of the DIB carriers for nine GIBS and ten GES fields. We also found a linear relation between the DIBλ8620 measured in this work and the near-infrared DIB in APOGEE spectra at 1.5273 μm, and we estimated the carrier abundance to be slightly lower compared to the DIBλ15273.Conclusions.We demonstrate that the DIB carriers can be located much closer to the observer than the background stars based on the following arguments: (i) qualitatively, the carriers occupy in the Galactic longitude–velocity diagram typical rotation velocities of stars in the local Galactic disk, while the background stars in the GIBS survey are mainly located in the Galactic bulge; (ii) quantitatively, all the derived kinematic distances of the DIB carriers are smaller than the median distances to background stars in each field. A linear correlation between DIBλ8620 and DIBλ15273 has been established, showing similar carrier abundances and making them both attractive for future studies of the interstellar environments.
Molecular cloud catalogue from 13CO (1–0) data of the Forgotten Quadrant Survey
Authors: Benedettini M. , Traficante A. , Olmi L. , Pezzuto S. , Baldeschi A. , Molinari S. , Elia D. , Schisano E. , Merello M. , Fontani F. , Rygl K. L. J. , Brand J. , Beltrán M. T. , Cesaroni R. , Liu S. J. , Testi L. 
Published: August 2021

Context. New-generation spectroscopic surveys of the Milky Way plane have been revealing the structure of the interstellar medium, allowing the simultaneous study of dense structures from single star-forming objects or systems to entire spiral arms.
Aims. The good sensitivity of the new surveys and the development of dedicated algorithms now enable building extensive catalogues of molecular clouds and deriving good estimates of their physical properties. This allows studying the behaviour of these properties across the Galaxy.
Methods. We present the catalogue of molecular clouds extracted from the 13CO (1–0) data cubes of the Forgotten Quadrant Survey, which mapped the Galactic plane in the range 220° < l < 240° and −2.​​° 5 < b < 0° in 12CO (1–0) and 13CO (1–0). We compared the properties of the clouds of our catalogue with those of other catalogues.
Results. The catalogue contains 87 molecular clouds for which the main physical parameters such as area, mass, distance, velocity dispersion, and virial parameter were derived. These structures are overall less extended and less massive than the molecular clouds identified in the 12CO (1–0) data-set because they trace the brightest and densest part of the 12CO (1–0) clouds. Conversely, the distribution of aspect ratio, equivalent spherical radius, velocity dispersion, and virial parameter in the two catalogues are similar. The mean value of the mass surface density of molecular clouds is 87 ± 55 M⊙ pc−2 and is almost constant across the galactocentric radius, indicating that this parameter, which is a proxy of star formation, is mostly affected by local conditions.
Conclusions. In data of the Forgotten Quadrant Survey, we find a good agreement between the total mass and velocity dispersion of the clouds derived from 12CO (1–0) and 13CO (1–0). This is likely because in the surveyed portion of the Galactic plane, the H2 column density is not particularly high, leading to a CO emission with a not very high optical depth. This mitigates the effects of the different line opacities between the two tracers on the derived physical parameters. This is a common feature in the outer Galaxy, but our result cannot be readily generalised to the entire Milky Way because regions with higher particle density could show a different behaviour.
Detection of non-linear resonances among gravity modes of slowly pulsating B stars: Results from five iterative pre-whitening strategies
Authors: Van Beeck J. , Bowman D. M. , Pedersen M. G. , Van Reeth T. , Van Hoolst T. , Aerts C. 
Published: August 2021

Context.Slowly pulsating B (SPB) stars are main-sequence multi-periodic oscillators that display non-radial gravity modes. For a fraction of these pulsators, 4-year photometric light curves obtained with theKeplerspace telescope reveal period spacing patterns from which their internal rotation and mixing can be inferred. In this inference, any direct resonant mode coupling is usually ignored.Aims.We re-analyse the light curves of a sample of 38 knownKeplerSPB stars. For 26 of them, the internal structure, including rotation and mixing, was recently inferred from their dipole prograde oscillation modes. Our aim is to detect direct non-linear resonant mode coupling among the largest-amplitude gravity modes.Methods.We extract up to 200 periodic signals per star with five different iterative pre-whitening strategies based on linear and non-linear regression applied to the light curves. We then identify candidate coupled gravity modes by verifying whether they fulfil resonant phase relations.Results.For 32 of the 38 SPB stars we find at least one candidate resonance that is detected in both the linear and the best non-linear regression model fit to the light curve and involves at least one of the two largest-amplitude modes.Conclusions.The majority of theKeplerSPB stars reveal direct non-linear resonances based on the largest-amplitude modes. These stars are thus prime targets for the non-linear asteroseismic modelling of intermediate-mass dwarfs to assess the importance of mode couplings in probing their internal physics.
The (im)possibility of strong chemical tagging
Authors: Casamiquela L. , Castro-Ginard A. , Anders F. , Soubiran C. 
Published: August 2021

Context.The possibility of identifying co-natal stars that have dispersed into the Galactic disc based on chemistry alone is called strong chemical tagging. It has been debated for a long time whether this is indeed feasible; it holds the promise of reconstructing the detailed star formation history of a large fraction of stars in the Galactic disc.Aims.We investigate the feasibility of strong chemical tagging using known member stars of open clusters.Methods.We analysed the largest sample of cluster members that have been homogeneously characterised with high-resolution differential abundances for 16 different elements. We also investigated the possibility of finding the known clusters in the APOGEE DR16 red clump sample with 18 chemical species. For both purposes, we used a clustering algorithm and an unsupervised dimensionality reduction technique to blindly search for groups of stars in chemical space.Results.Even if the internal coherence of the stellar abundances in the same cluster is high, typically 0.03 dex, the overlap in the chemical signatures of the clusters is large. In the sample with the highest precision and no field stars, we only recover 9 out of the 31 analysed clusters at a 40% threshold of homogeneity and precision. This ratio slightly increases when we only use clusters with 7 or more members. In the APOGEE sample, field stars are present along with four populated clusters. In this case, only one of the open clusters was moderately recovered.Conclusions.In our best-case scenario, more than 70% of the groups of stars are in fact statistical groups that contain stars belonging to different real clusters. This indicates that the chances of recovering the majority of birth clusters dissolved in the field are slim, even with the most advanced clustering techniques. We show that different stellar birth sites can have overlapping chemical signatures, even when high-resolution abundances of many different nucleosynthesis channels are used. This is substantial evidence against the possibility of strong chemical tagging. However, we can hope to recover some particular birth clusters that stand out at the edges of the chemical distribution.
Die Medizinische Indikation – eine besondere Betrachtung zur Anwendung von Außenseiter- und Neulandmethoden
Authors: Netzer-Nawrocki Juliane 
Published: August 2021

ZusammenfassungAnknüpfungspunkt für die Frage, ob eine ärztliche Leistung „medizinisch indiziert“ war, ist meist ein Streit über die Übernahme der Kosten der Behandlung. Die Krankenversicherung des Patienten – privat oder gesetzlich – stellt in Frage, dass eine durchgeführte oder geplante ärztliche Maßnahme überhaupt erforderlich ist. Dies kann sowohl anerkannte schulmedizinische Leistungen betreffen als auch die Durchführung von Außenseiter- und Neulandmethoden, denen die wissenschaftliche Anerkennung (noch) fehlt. Aber auch bei arzthaftungsrechtlichen Auseinandersetzungen kommt der medizinischen Indikation aufgrund des medizinischen Fortschritts eine wachsende Bedeutung zu. Der folgende Beitrag legt einen Schwerpunkt auf die medizinische Indikation bei Außenseiter- und Neulandmethoden und stellt die hierzu relevante Rechtsprechung dar.
Alkaloids from Lime Flower (Tiliae flos) Exert Spasmodic Activity on Murine Airway Smooth Muscle Involving Acetylcholinesterase
Authors: Hake Alexander , Symma Nico , Esch Stefan , Hensel Andreas , Düfer Martina 
Published: August 2021

AbstractLime flower (Tiliae flos) is traditionally used either for treatment of the common cold or to relieve symptoms of mental stress. Recently, the presence of a new class of piperidine and dihydro-pyrrole alkaloids from lime flower has been described. The present study aimed to investigate the pharmacological activity of hydroacetonic lime flower extracts, alkaloid-enriched lime flower fractions, and isolated alkaloids on the murine airway smooth muscle and the cholinergic system. While a hydroacetonic lime flower extract did not show any pharmacological activity, enriched Tilia alkaloid fractions potentiated acetylcholine-induced contractions of the trachea by ~ 30%, showing characteristics comparable to galanthamine. Effects were abrogated by atropine, indicating an involvement of muscarinic receptors. The dihydro-pyrrole alkaloid tiliine A, the piperidine alkaloid tiliamine B, and the acetylated piperidine alkaloid tilacetine A were characterized as
acetylcholinesterase inhibitors. The positive control galanthamine (IC50 = 2.0 µM, 95% CI 1.7 to 2.2 µM) was approximately 100 times more potent compared to tiliine A (IC50 = 237 µM, 95% CI 207 to 258 µM) and tiliamine B (IC50 = 172 µM, 95% CI 158 to 187 µM). Neither DNA synthesis of HepG2 liver cells, HaCaT keratinocytes, and Caco-2 intestinal epithelial cells nor cell viability of primary human fibroblasts was reduced by the alkaloids. The indirect cholinergic activity of the alkaloids might explain some aspects of the traditional use of lime flowers and may extend the portfolio of compounds with regard to diseases involving parasympathetic malfunction or central cholinergic imbalance.
Arterial Thrombosis in Cancer Patients: An Update
Authors: Franchini Massimo , Tufano Antonella , Casoria Aniello , Coppola Antonio 
Published: August 2021

AbstractCancer is associated with an increased incidence of both venous thromboembolism (VTE) and arterial thrombosis (cardiovascular events and ischemic stroke). Cancer-associated arterial thrombotic events are less well studied than VTE, but increasingly recognized, particularly in specific malignancies and in association with specific anticancer therapies. The pathogenesis of arterial thrombotic events in cancer is complex and involves generation of tumor-associated procoagulant factors and a variety of alterations in platelet function as well as in the coagulation and fibrinolytic systems, and endothelial injury and dysfunction, that combine to produce hypercoagulability. The multifactorial interaction between this prothrombotic state, the individual cardiovascular risk, advanced age and presence of comorbidities, and the specific neoplasm characteristics and therapy, may induce the vascular events. Recent studies based on population databases and prospective or retrospective analyses with prolonged follow-up highlight that cancer patients experience an increased (approximately 1.5–2-fold) risk of both cerebrovascular and cardiovascular events compared with noncancer individuals, which peaks in the time period of the diagnosis of cancer but may persist for years. Beyond the type of cancer, the risk reflects the tumor burden, being higher in advanced stages and metastatic cancers. The occurrence of arterial thromboembolic events is also associated with increased overall mortality. We here present an update of the pathophysiology, risk factors, clinical evidence, and treatment considerations on cancer-associated arterial thrombosis, in the light of the need for specific multidisciplinary prevention and surveillance strategies in this setting, in the frame of cardio-oncology approaches.
Promoting the Conduct of Medical Education Journal Clubs in Teaching Medical Institutions
Authors: Shrivastava Saurabh R. , Shrivastava Prateek S. 
Published: August 2021

AbstractBackground A critical appraisal of a research article as a part of journal club sessions is an essential aspect of postgraduate training across different medical institutions in varied settings. The purpose of the current review was to explore the merits of medical education journal clubs and identify the potential factors that need to be considered for conducting these journal clubs in medical institutions.Methods An extensive search of all materials related to the topic was performed in the PubMed search engine and a total of 51 studies were included in the review based on the suitability with the current review objectives. Keywords used in the search include medical education journal clubs in the title only (viz., journal club [ti] AND medical education [ti]; medical education journal clubs [ti]; journal club [ti]). The articles published in English language only were included in the review.Results Regardless of the extensive employment of the journal clubs in different medical specialties, it is quite alarming to note that not many institutions conduct journal clubs targeting the field of medical education. These sessions offer a unique opportunity to the participants to assess the literature in a supportive fashion and play a defining role in ensuring better quality health care teachings to the medical students. However, we must understand that the successful conduct of medical education journal clubs requires specific considerations and groundwork, so that the students may benefit.Conclusion In conclusion, the medical education journal clubs have not been frequently conducted, as more preference has been given to the subject-specialty journal clubs. However, considering the scope and benefits that journal clubs add to improve teaching, all medical institutions should advocate to conduct medical education journal clubs within their premises in a structured manner.
Intrapartum Fetal Electrocardiogram in Small- and Large-for-Gestational Age Fetuses
Authors: Braginsky Lena , Weiner Steven J. , Saade George R. , Varner Michael W. , Blackwell Sean C. , Reddy Uma M. , Thorp John M. , Tita Alan T.N. , Miller Russell S. , McKenna David S. , Chien Edward K.S. , Rouse Dwight J. , El-Sayed Yasser Y. , Sorokin Yoram , Caritis Steve N. ,   for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) Network
Published: August 2021

Objective This study aimed to evaluate whether intrapartum fetal electrocardiogram (ECG) tracings with ST-elevation or depression occur more frequently in each stage of labor in small-for-gestational age (SGA) or large-for-gestational age (LGA), as compared with appropriate-for-gestational age (AGA) fetuses.
Study Design We conducted a secondary analysis of a large, multicenter trial in which laboring patients underwent fetal ECG waveform-analysis. We excluded participants with diabetes mellitus and major fetal anomalies. Birth weight was categorized as SGA (<10th percentile), LGA (>90th percentile), or AGA (10–90th percentile) by using a gender and race/ethnicity specific nomogram. In adjusted analyses, the frequency of ECG tracings with ST-depression or ST-elevation without depression was compared according to birthweight categories and labor stage.
Results Our study included 4,971 laboring patients in the first stage and 4,074 in the second stage. During the first stage of labor, there were no differences in the frequency of ST-depression in SGA fetuses compared with AGA fetuses (6.7 vs. 5.5%; adjusted odds ratio [aOR]: 1.41, 95% confidence interval [CI]: 0.93–2.13), or in ST-elevation without depression (35.8 vs. 34.1%; aOR: 1.17, 95% CI: 0.94–1.46). During the second stage, there were no differences in the frequency of ST-depression in SGA fetuses compared with AGA fetuses (1.6 vs. 2.0%; aOR: 0.69, 95% CI: 0.27–1.73), or in ST-elevation without depression (16.2 vs. 18.1%; aOR: 0.90, 95% CI: 0.67–1.22). During the first stage of labor, there were no differences in the frequency of ST-depression in LGA fetuses compared with AGA fetuses (6.3 vs. 5.5%; aOR: 0.97, 95% CI: 0.60–1.57), or in ST-elevation without depression (33.1 vs. 34.1%; aOR: 0.80, 95% CI: 0.62–1.03); during the second stage of labor, the frequency of ST-depression in LGA compared with AGA fetuses (2.5 vs. 2.0%, aOR: 1.36, 95% CI: 0.61–3.03), and in ST-elevation without depression (15.5 vs. 18.1%; aOR: 0.83, 95% CI: 0.58–1.18) were similar as well.
Conclusion The frequency of intrapartum fetal ECG tracings with ST-events is similar among SGA, AGA, and LGA fetuses.
Key Points
The personalization of party politics in Western Europe (1985–2016): evidence from an expert survey
Authors: Marino Bruno , Martocchia Diodati Nicola , Verzichelli Luca 
Published: August 2021

AbstractThe personalization of politics has been extensively studied from different angles and in different national contexts. Nonetheless, an easily comparable and longitudinal study of the personalization of politics at both the country and the party levels is still missing. In this article, we fill this gap by presenting data from an expert survey on the personalization of politics for around 110 parties and a series of Western European countries from the mid-1980s to the mid-2010s. The dimensions analyzed concern the impact of the personalization of politics in general elections, and also party leaders' room for maneuver in candidate selection, the definition of the party's policy-making agenda, and party leaders’ intra-party control. Different reliability tests confirm the goodness of the data collected. At the same time, first descriptive analyses show that there has not been a homogenous diffusion of this phenomenon in Western Europe, and diverging personalization trends are present for different groups of countries or different dimensions of this phenomenon.