bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single Incision Approach for Decompression of Greater, Lesser and Third Occipital Nerves in Migraine Surgery
Authors: Olla Danielle , Mailey Brian 
Published: July 2021

Abstract
Background

The traditional approach for occipital migraine surgery encompasses 3 separate surgical incisions in the posterior neck to decompress the great occipital nerves (GON), lesser occipital nerves (LON) and third occipital nerves (TON). We sought to evaluate a single midline incision approach for decompression of all 6 occipital nerves.
Methods

Using 10 cadaveric hemi-sides (5 fresh cadaver head and necks). Anatomic landmarks and the location of the bilateral GON, LON and TON were marked according to previous anatomic studies. A single midline 9-cm incision was made and lateral skin flaps were raised to decompress or avulse all 6 nerves.
Results

The GON and TON were identified 3.5 and 6.2 cm, respectively inferior to a line bisecting the external auditory canal (EAC) and 1.5 cm lateral to the midline. The LON was identified 6-cm inferior and 6.5-cm medial to a line bisecting the EAC in the plane just above the investing layer of the deep cervical fascia until the posterior boarder of the sternocleidomastoid was encountered. The LON had the greatest amount of variation, but was identified lateral to the posterior border of the SCM.
Conclusions

A single midline incision approach allows for successful identification and decompression of all 6 occipital nerves in migraine surgery.
Role of FRG1 in predicting the overall survivability in cancers using multivariate based optimal model
Authors: Khan Rehan , Palo Ananya , Dixit Manjusha 
Published: July 2021

Abstract
FRG1 has a role in tumorigenesis and angiogenesis. Our preliminary analysis showed FRG1 expression is associated with the overall survival (OS) in cancers the effect varies. In cervix and gastric cancers, we found a clear difference in the OS between the low and high FRG1 expression groups, but in breast, lung, and liver cancers the difference was not prominent. We hypothesized that the functionality of the genes correlated with FRG1 could be getting affected by FRG1 or vice versa, which might mask the effect of a single gene on the OS analysis in cancer patients. We used the multivariate Cox regression, risk score, and Kaplan Meier analyses to determine OS in a multigene model. STRING, Cytoscape, and HIPPIE were used to deduce FRG1 associated pathways. In breast, lung, and liver cancer we found a distinct difference in the OS, between the low and high FRG1 expression groups in the multigene model, suggesting an independent role of FRG1 in survival. Risk scores were calculated based upon regression coefficients in the multigene model. Low and high-risk score groups revealed a significant difference in the FRG1 expression and survival. HPF1, RPL34, and EXOSC9 were the most common genes present in FRG1 associated pathways across the cancer types. Validation of the effect of FRG1 expression on these genes by qRT-PCR, supports that FRG1 might be an upstream regulator of their expression. These genes may have multiple regulators which also affect their expression, leading to the masking effect in the survival analysis. In conclusion, our study highlights the role of FRG1 in the survivability of cancer patients in tissue-specific manner and the use of multigene models in prognosis.
Systemic delivery of rAAV9‐IκBα stabilized atherosclerotic plaques and attenuated intra-plaque inflammation by inhibiting nuclear factor-κB activation in apolipoprotein E–deficient mice
Authors: Chen Qing-Jie , Liu Fen , Wang Xue-Mei , Xie Jia , Zhao Long , Zhai Hui , Chen Bang-Dang , Ma Yi-Tong , Li Xiao-Mei , Gao Xiao-Ming , Yang Yi-Ning 
Published: July 2021

Abstract
Background: The activated nuclear factor (NF)-κB pathway in atherosclerotic plaques promotes the progression of atherosclerosis. Targeting of plaque NF-κB may provide a novel strategy for limiting chronic inflammation. This study was conducted to examine the effect of NF-κB inhibition by using recombinant adeno-associated virus 9 (AAV9) to deliver IκBα (AAV9‐IκBα) which can be overexpressed to influence atherosclerosis.Methods and Results: Systemic delivery of AAV9‐IκBα resulted in ~2-fold overexpression of IκBα protein in the atherosclerotic plaques of apolipoprotein E-/- mice fed a high-fat diet. AAV9‐IκBα delivery did not affect the body weight or lipid deposition and plaque size in the mice. During plaque formation, overexpression of IκBα suppressed intra-plaque macrophage infiltration, inhibited the expression of pro-inflammatory genes including interleukin-6, monocyte chemoattractant protein-1, tumor necrosis factor-α and matrix metalloproteinase, enhanced the contents of collagen and vascular smooth muscle cells, and decreased the plaque vulnerability index by inhibiting the phosphorylation of NF-κB subunit p65 and its nuclear translocation. Conclusions: Systemic delivery of AAV9-IκBα promotes plaque stability by inhibiting NF-κB activation and suppressing intra-plaque inflammation, suggesting that inhibition of the NF-κB pathway in atherosclerotic plaques is a promising approach for treating atherosclerosis.
Comparing the Fracture Resistance and Modes of Failure in Different Types of CAD/CAM Zirconia Abutments with Internal Hexagonal Implants: An in Vitro Study
Authors: Chang Yu-Tsen , Wu Yu-Ling , Chen Hung-Shyong , Tsai Ming-Hsu , Chang Chia-Chen , Wu Aaron Yu-Jen 
Published: July 2021

Abstract
3 groups of zirconia abutments (n=3) made of different connection design or manufacturers were investigated (All-Zr, ASC-Zr and AM-Zr groups). All-electric dynamic test instrument was used to place static loading on specimen with a crosshead speed set at 1 mm/min. One-way analysis of variance (ANOVA) and post hoc Tukey tests (α=.05) were used for statistical evaluation. The mean fracture resistance was 258.21±68.60 N for All-Zr group, 360.55±29.66 N for ASC-Zr group, and 341.45±25.97 N for AM-Zr group. There was no significant difference in fracture resistance between the 3 groups (1-way ANOVA, P = 0.10). The modes of failure among the 3 types of abutments are different. The All-Zr group showed an oblique fracture line starting from the buccal aspect at the region of the implant platform. While in the ASC-Zr group and the AM-Zr group showed a relatively horizontal fracture line with greater distance from implant platform. The titanium inserts cannot significantly improve the fracture resistance of the zirconia abutment. However, they may alter the modes of failure, allowing buccal fracture surfaces of the zirconia abutments to be placed away from the implant platform, thereby protecting the implant-abutment connection.
Impact of Cooling Method on the Outcome of Initial Shockable or Non-Shockable Out of Hospital Cardiac Arrest Patients Receiving Target Temperature Management: A Nationwide Multicentre Prospective Cohort Study
Authors: Watanabe Makoto , Matsuyama Tasuku , Oe Hikaru , Sasaki Makoto , Nakamura Yuki , Miyamoto Yuki , Okada Nobunaga , Kitamura Tetsuhisa , Ohta Bon 
Published: July 2021

Abstract
Background: Little is known about the effectiveness of surface cooling (SC) and endovascular cooling (EC) on the outcome of out-of-hospital cardiac arrest (OHCA) patients receiving target temperature management (TTM) according to their initial rhythm.Methods: We retrospectively analysed data from the Japanese Association for Acute Medicine Out‐of‐Hospital Cardiac Arrest registry, a multicentre, prospective nationwide database in Japan. For our analysis, OHCA patients aged ≥ 18 years who were treated with TTM between June 2014 and December 2017 were included. The primary outcome was 30-day survival with favourable neurological outcome defined as a Glasgow-Pittsburgh cerebral performance category score of 1 or 2. Cooling methods were divided into the following groups: SC (ice packs, fans, air blankets, and surface gel pads) and EC (endovascular catheters and any dialysis technique). We investigated the efficacy of the two categories of cooling methods in two different patient groups divided according to their initially documented rhythm at the scene (shockable or non-shockable) using multivariable logistic regression analysis and propensity score analysis with inverse probability weighting (IPW).Results: In the final analysis, 1082 patients were included. Of these, 513 (47.4%) had an initial shockable rhythm and 569 (52.6%) had an initial non-shockable rhythm. The proportion of patients with favourable neurological outcomes in SC and EC was 59.9% vs. 58.3% (264/441 vs. 42/72), 11.8% and (58/490) vs. 21.5% (17/79) in the initial shockable patients and the initial non-shockable patients, respectively. In the multivariable logistic regression analysis, differences between the two cooling methods were not observed among the initial shockable patients (adjusted odd ratio [AOR] 1.45, 95% CI 0.81–2.60), while EC was associated with better neurological outcome among the initial non-shockable patients (AOR 2.13, 95% CI 1.10–4.13). This association was constant in propensity score analysis with IPW (OR 1.40, 95% CI 0.83–2.36; OR 1.87, 95% CI 1.01–3.47 among the initial shockable and non-shockable patients, respectively).Conclusion: We demonstrated that the use of EC was associated with better neurological outcomes in OHCA patients with initial non-shockable rhythm, but not in those with initial shockable rhythm. A TTM implementation strategy based on initial rhythm may be important.Trial registration: None
Investigation of 2nd Order Nonlinear Optical Property Semi organic L-Tyrosine Barium Chloride Single Crystal for Photonic applications
Authors: Vivekanandhan R. , Sudhagar G. , Raju K. , Jarin T. , Venkatesan Chithambaram 
Published: July 2021

Abstract
New bulk size single crystals of L-Tyrosine Barium Chloride LTBC have been synthesized from the solution prepared from the blend of tyrosine and barium chloride using slow evaporation solution growth method. Single crystal X-ray diffraction analysis shows the grown crystal crystallized in orthorhombic system with non-centrosymmetric space group P. Fourier transform infrared spectral studies revealed the orientation of discrete functional group in the grown crystal. The optical absorption studies show the material has largish optical transparency in the total visible region. The band gap energy values were also determined by using the optical studies. SHG efficiency was confirmed by Kurtz Perry powder technique. The thermal stability of LTBC crystals was analyzed by DSC technique. The electrical behavior of the crystal was studied by dielectric method. The SEM image expelled the surface morphology of the grown crystal. The hardness values of crystal were estimated by Vickers micro hardness tester and other such properties show the suitableness of the LTBC crystal for photonic and optoelectronic applications.
circular RNA CircITCH (has-circ-0001141) suppresses hepatocellular carcinoma (HCC) progression by sponging miR-184
Authors: Guo Xuan , Wang Ziying , Deng Xue , Lu Yantong , Huang Xuhui , Lin Juze , Wang Changjun 
Published: July 2021

Abstract
Background
Aberrant expression of circular RNA(circRNA)is involved in the occurrence of various diseases and tumor development, in which plays a vital role, including hepatocellular carcinoma (HCC). Nevertheless, the regulation mechanism and biological function of circITCH in hepatocellular carcinoma (HCC) remain unclear.
Methods
The expression level of circular RNA itchy E3 ubiquitin protein ligase (circ-ITCH) was identified and validated by real-time polymerase chain reaction (RT-qPCR) in HCC cell lines. The stability of circITCH was confirmed by Ribonuclease R (RNase R) assay. Subsequently, through silencing and overexpression of circITCH to investigate the functional roles of circITCH in HCC proliferation, invasion and apoptosis. We also carried out bioinformatics analysis, luciferase reporter assays to define the relationship between microRNA (miR)-184 and circITCH.
Results
CircITCH (hsa_circ_0001141) was a stable circRNA and downregulated in HCC cells. Overexpression of circITCH inhibited cell proliferation, migration, invasion and promoted apoptosis in vitro, whereas knockdown of circITCH had the opposite effects. Mechanistically, miR-184 could be sponged by circITCH, and its overexpression could mitigate the suppressive effects of circITCH overexpression on HCC progression. Through biological website to predict the target genes of miR-184 may be combined. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to investigate mRNAs with significant functional enrichment and pathways, also which its relationship with HCC related pathway and immune cells.
Conclusions
Our findings reveal that circITCH served as a repressor to restrain HCC malignancy via miR-184. Therefore, circITCH may serve as a potential prognostic marker and therapeutic target for HCC.
Selected ‘Starter Kit’ energy system modelling data for Papua New Guinea (#CCG)
Authors: Allington Lucy , Cannone Carla , Pappis Ioannis , Barron Karla Cervantes , Usher Will , Pye Steve , Brown Edward , Howells Mark , Walker Miriam Zachau , Ahsan Aniq , Charbonnier Flora , Halloran Claire , Hirmer Stephanie , Taliotis Constantinos , Sundin Caroline , Sridha Vignesh , Ramos Eunice , Brinkerink Maarten , Deane Paul , Gritsevskyi Andrii , Moura Gustavo , Rouget Arnaud , Wogan David , Barcelona Edito , Rogner Holger , Cronin Jen 
Published: July 2021

Abstract
Energy system modelling can be used to assess the implications of different scenarios and support improved policymaking. However, access to data is often a barrier to energy system modelling, causing delays. Therefore, this article provides data that can be used to create a simple zero order energy system model for Papua New Guinea, which can act as a starting point for further model development and scenario analysis. The data are collected entirely from publicly available and accessible sources, including the websites and databases of international organizations, journal articles, and existing modelling studies. This means that the dataset can be easily updated based on the latest available information or more detailed and accurate local data. These data were also used to calibrate a simple energy system model using the Open Source Energy Modelling System (OSeMOSYS) and two stylized scenarios (Fossil Future and Least Cost) for 2020–2050. The assumptions used and results of these scenarios are presented in the appendix as an illustrative example of what can be done with these data. This simple model can be adapted and further developed by in-country analysts and academics, providing a platform for future work.
Effect of fecal matter co-digestion with kitchen waste on Hermetia illucens’ larval weight and protein content
Authors: Matheka Rosemary M. , Raude James M. , Murunga Sylvia I. , Riungu Joy N. , Wandera Simon M. 
Published: July 2021

Abstract
Sustainable treatment of fecal matter is a long-standing challenge in sanitation, particularly in developing countries. Although recent developments have seen the evolution of innovative onsite sanitation technologies, the treatment of fecal waste collected still remains a daunting task. This study evaluated the effect of formulated feedstock: fecal matter from urine-diverting dry toilets and kitchen waste (1:0, 1:1, 2:1, 4:1, and 0:1) on waste weight reduction, Hermetia illucens’ larval weight gain, and crude protein content during co-digestion. Samples were collected after every 2 days for larval weight determination and protein content analysis using the Kjeldahl method of nitrogen determination. The waste reduction index (WRI) was determined after 50% pupation. The larvae grew on all substrates yielding 32.97–38.6% dry matter (DM) protein content and larval weight ranging from 1.12 to 1.70 g per five larvae. Results indicate that a 1:1 co-digestion ratio resulted in a high WRI (3.61), DM crude protein content (38.6%), and larval weight (1.70 g per five larvae). This study used the circular economy-based approach which provides a win–win situation to sanitation provision and environmental management while realizing products with potential for livelihood improvement.
Ethnomathematics study in calendar system of Baduy tribe
Authors: Arisetyawan Andika , Supriadi Supriadi 
Published: July 2021

The aim of this research is to study ethnomathematics in the calendar system of the baduy tribe. The study of ethnomathematics in our research used ethnography methods. We found a unique pattern in baduy calendar that the first day in the previous month + 2 days after the first day of the previous month equals to the first day in the next month, in which, it is the reason why baduy people who have no mathematical knowledge from the formal school can predict, for an example, the first day in the next months.
The type of ethnomathematics in fish trading in sapuran market, Wonosobo
Authors: Rachmanto Awal Mulia , Purwoko Riawan Yudi 
Published: July 2021

This study aims to reveal the type of ethnomathematics used in the process of counting fish in Sapuran Market, Wonosobo, which can be applied in teaching processes. The method used in this study is the observation of fish trading and interviews with fish traders in Sapuran Market, Wonosobo. The research findings show that the process of counting fish in the market applies ethnomathematics, including the addition of integer and reduction of the integer. The mathematical concept used in the addition operation is the storing technique, while the reduction operation applies the borrowing technique. The implementation of mathematics teaching using the ethnomathematics approach adopted from the activities of fish counting at Sapuran Market, Wonosobo can help improve students’ understanding of the addition and reduction materials for elementary school.
Eksplorasi etnomatematika pada Masjid Jami' Al-Baitul Amien Jember
Authors: Yudianto Erfan , Febriyanti Rizka Amalia , Sunardi Sunardi , Sugiarti Titik , Mutrofin Mutrofin 
Published: July 2021

Tujuan penelitan ini adalah untuk menggali etnomatematika pada bangunan Masjid Jami’ Al-Baitul Amien Jember yang kemudian digunakan sebagai bahan untuk membuat paket tes matematika bagi siswa. Penelitian ini merupakan penelitian kualitatif dengan pendekatan etnografi. Metode pengumpulan data yang digunakan adalah observasi dan wawancara. Subjek penelitian yaitu tiga observer dan dua narasumber yakni pengurus Yayasan Masjid Jami’ Al-Baitul Amien Jember. Satu orang merupakan ketua pengurus yang paham tentang sejarah Masjid Jami’ Al-Baitul Amien dan satu orang merupakan satu-satunya pengurus yang mengikuti masa pembangunan sehingga mengerti terhadap struktur bangunan masjid. Hasil penelitian menunjukkan bahwa pada bagian-bagian bangunan Masjid Jami’ Al-Baitul Amien Jember terdapat konsep-konsep matematika. Bagian-bagian bangunan yang dimaksud yaitu kubah masjid, tiang penyangga masjid, lantai dua, dinding pancuran Ruang Wudlu, dan menara masjid. Konsep-konsep matematika yang muncul adalah bangun datar, bangun ruang, kekongruenan, dan refleksi.Ethnomathematics exploration at the Jami 'Al-Baitul Amien Jember MosqueAbstractThe purpose of this research is to explore ethnomathematics at the Jami 'Al-Baitul Amien Jember Mosque building which is then used as material to design mathematics test packages for students. This research was a qualitative study with an ethnographic approach. The data collection methods used were observations and interviews. The research subjects were three observers and two resource persons, namely the management of the Jami 'Al-Baitul Amien Jember Mosque Foundation. One person is the chairman of the committee who understands the history of the Jami 'Al-Baitul Amien Mosque and one person is the only administrator who followed the construction period so that he understands the structure of the mosque building. The results show that the parts of the Jami 'Al-Baitul Amien Jember Mosque have mathematical concepts. The building parts meant are the dome of the mosque, the pillars of the mosque, the second floor, the shower wall of the Wudlu Room, and the mosque tower. Mathematical concepts that emerge are 2D shapes, 3D shapes, congruence, and reflection.
Caracterización de las investigaciones de tesis de posgrado en enfermería
Authors: Hernández-Márquez C. , Ojeda-Chacón T. , Torres-Paz P.I. , Arizmendi-Jaime E. 
Published: July 2021

Introducción: En la elaboración de tesis de posgrado los estudiantes se acercan a la investigación y adquieren competencias en sus campos disciplinares. El análisis de sus características permite reconocer tendencias respecto a las decisiones para el desarrollo del conocimiento científico e identificar áreas de oportunidad en la generación del conocimiento.
Objetivo: Identificar las características de los trabajos de tesis realizados por egresados de maestría y especialidad en enfermería.
Métodos: Estudio retrospectivo, transversal, descriptivo. Se analizaron 144 tesis presentadas entre 2013 a 2018, se determinó la correspondencia del tema con la LGAC y programa cursado, el objeto de estudio, metodología utilizada y tipo de estudio realizado.
Resultados: Los temas de la especialidad en administración corresponden 91.7% con administración, los de especialidad en atención al adulto en estado crítico tienen una correspondencia del 86% con la atención integral institucional, en el caso de maestría 51.1% corresponde con temas de cuidado y promoción de la salud. El objeto de estudio predominante fue el actuar enfermero (52.8%), conocimientos de los profesionales (60%) y calidad de atención (32%). 91% utilizó metodología cuantitativa, prevalecieron en 88.9% los estudios observacionales.
Discusión: Los resultados muestran la necesidad de ampliar la formación en investigación de estudiantes y docentes del posgrado en Enfermería.
Conclusión: Los temas abordados en las tesis tienen correspondencia con los objetivos de los programas. La metodología más utilizada fue la cuantitativa y el estudio observacional, con estudios de enfermería centrados en intervenciones para el mejoramiento de los problemas que enfrenta el paciente y los profesionales.
Agama dan Kebudayaan Masyarakat Perspektif Clifford Geertz
Authors: Riady Ahmad Sugeng 
Published: July 2021

This article starts from the fact that religion and culture are two areas that often trigger pro and contra. On the one hand, there are many figures who clearly define the boundaries between religion and culture, while on the other hand there are also figures who continue to seek formulations of their relationship with the assumption that religion and culture provide mutual support. Clifford Geertz, an anthropologist born in San Francisco, contributed to the idea of religion and culture. This article uses the literature study method. The literature used is books that are supported by journals and previous research that are relevant to the topic the author raises. The result is that Clifford Geertz assesses human culture as a text that needs to be interpreted or thick description. This also applies when studying religious phenomena that occur in the midst of a society which is not only explained but come to the discovery of the meaning of these religious phenomena.
Abstrak
Artikel ini berangkat dari fakta bahwa agama dan kebudayaan sering kali menjadi dua wilayah yang memicu terjadinya pro dan kontra. Di satu sisi ada banyak tokoh yang secara tegas memberi batas antara agama dan kebudayaan, sedangkan di sisi lain ada juga tokoh yang terus mencari formulasi dari relasi keduanya dengan asumsi bahwa, agama dan kebudayaan saling memberi dukungan. Adalah Clifford Geertz, antropolog kelahiran San Fransisco turut memberi kontribusi gagasan mengenai agama dan kebudayaan. Artikel menggunakan kajian literatur. Literatur yang digunakan ialah buku-buku yang ditunjang dengan jurnal dan penelitian terdahulu yang relevan dengan topik yang penulis angkat. Adapun hasilnya ialah Clifford Geertz menilai kebudayaan manusia sebagai sebuah teks yang perlu diinterpretasikan (thick description). Hal ini juga berlaku ketika mengkaji fenomena agama yang terjadi di tengah-tengah masyarakat yang tidak hanya dijelaskan, tapi sampai pada penemuan pemaknaan dari fenomena keagamaan tersebut.