bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allergische Reaktionen auf COVID-19-Impfungen – Was HNO-Ärzte wissen sollten – Teil 1: Immunologische Grundlagen von Allergien auf Impfstoffe, Immunmechanismen von allergischen und pseudoallergischen Reaktionen; Teil 2: Charakteristika der mRNA-Impfstoffe BNT162b2- und mRNA-1273 zur Prophylaxe von COVID-19 und assoziierte Immunphänomene; Teil 3: Praktische Aspekte der Prophylaxe, Diagnostik und Therapie von Allergien auf COVID-19-Impfstoffe
Authors: Klimek L. , Chaker A. M. , Cuevas M. 
Published: March 2021

ZusammenfassungObwohl allergische Reaktionen auf mRNA-COVID-19-Impfstoffe selten sind, ist durch die hohe Zahl der durchzuführenden Impfungen mit Anaphylaxien bei Personen zu rechnen, die zuvor auf Impfstoffkomponenten sensibilisiert wurden. Dargelegt werden hier praktische Aspekte zu diagnostischen Möglichkeiten, zur Prävention, zum Erkennen und zur Therapie einer anaphylaktischen Reaktion. Risikopopulationen, die nicht geimpft werden sollten oder die eine allergologische Abklärung vor Impfung benötigen, werden besprochen. Patienten mit Allergien des atopischen Formenkreises sowie Insektengiftallergiker zeigen aus allergologischer Sicht kein erhöhtes Risiko für eine Anaphylaxie durch eine COVID-Impfung.
Synthesis of Benzo-Fused Cyclic Compounds via Rhodium-Catalyzed Decarboxylative Coupling of Aromatic Carboxylic Acids with Alkynes
Authors: Satoh Tetsuya , Inai Yasuhito , Usuki Yoshinosuke 
Published: March 2021

AbstractThe decarboxylative coupling of diversely substituted benzoic acids with internal alkynes proceeds smoothly in the presence of a [RhCl(cod)]2/1,2,3,4-tetraphenyl-1,3-cyclopentadiene catalyst system to selectively produce highly substituted naphthalene derivatives. The catalyst system is applicable to constructing anthracene and benzo­[c]thiophene frameworks through reactions of naphthoic and thiophene-2-carboxylic acids, respectively.
Transmastoid Trautman's Triangle Combined Low Retrosigmoid Approach for Foramen Magnum Meningiomas: Surgical Anatomy and Technical Note
Authors: Di Guangfu , Zhou Wei , Fang Xinyun , Li Qiang , Sun Lean , Jiang Xiaochun 
Published: March 2021

Abstract
Objective This study was aimed to assess the potential of utilizing a transmastoid Trautman's triangle combined low retrosigmoid approach for ventral and ventrolateral foramen magnum meningiomas (FMMs) surgical treatment.
Methods We simulated this transmastoid Trautman's triangle combined low retrosigmoid approach using five adult cadaveric heads to explore the associated anatomy in a step-by-step fashion, taking pictures of key positions as appropriate. We then employed this approach in a single overweight patient with a short neck who was suffering from large ventral FMMs and cerebellar tonsillar herniation.
Results Through cadaver studies, we were able to confirm that this transmastoid Trautman's triangle combined with low retrosigmoid approach achieves satisfactory cranial nerve and vasculature visualization while also offering a wide view of the whole of the ventrolateral medulla oblongata. We, additionally, have successfully employed this approach to treat a single patient suffering from large ventral FMMs with cerebellar tonsillar herniation.
Conclusion This transmastoid Trautman's triangle combined low retrosigmoid approach may represent a complement to treatment strategies for ventral and ventrolateral FMMs, particularly in patients with the potential for limited surgical positioning due to their being overweight, having a short neck and suffering from cerebellar tonsillar herniation.
High Rate of Studies with Level 1 and 2 Evidence among the 100 Most Cited Articles in Lumbar Spinal Stenosis
Authors: Martínez-Andrés Juan , Ayala-Gascón María , Mariscal Gonzalo , Alfonso-Beltrán Joaquín , Barrios Carlos 
Published: March 2021

Abstract
Background To date, no study has used bibliometric analysis to review the most influential articles in lumbar spinal stenosis. The objective of this study was to identify and analyze the characteristics and the level of evidence of the 100 most cited articles on lumbar spinal stenosis
Methods The Thomson Reuters Web of Science was accessed to find the 100 most cited articles on lumbar spinal stenosis. For each article, we recorded the number and density of citations, authors, country, journals and years, department, level of evidence, type of study, and if it was part of any multicenter studies.
Results Until January 2017, the 100 most cited articles accumulated 11,136 citations (average: 259.05/y), ranging individually between 442 and 50 (average: 111.36). The first reference was published in 1974 in Clinical Orthopaedics and Related Research. Therapeutic studies (n = 40), the 1990s (n = 46), United States as country of origin (n = 51), Harvard University as institution (n = 16), Katz JN as author (n = 10), and Spine as journal (n = 48) have the hegemony. Many were multicenter (n = 42) and using level 2 evidence (n = 49). There is an inverse relationship between citation index and long-standing studies, maintenance of those most cited, and a temporary advance toward better levels of evidence.
Conclusion This bibliometric analysis reveals a good level of evidence in the published clinical series and includes 100 articles useful for the approach of lumbar spinal stenosis.
Impact of Type of Treatment Center and Access to Care on Mortality and Survival for Skull Base Chordoma and Chondrosarcoma
Authors: Holtzman Adam L. , Bates James E. , Morris Christopher G. , Rutenberg Michael S. , Indelicato Daniel J. , Tavanaiepour Daryoush , Mendenhall William M. 
Published: March 2021

AbstractIntroduction In adults with skull base chordoma or chondrosarcoma, the impact of treatment center and access to care have not been well described in regard to perioperative mortality and survival.Methods A query of the National Cancer Database (NCDB) and review of 1,102 adults—488 with chordomas and 614 with chondrosarcomas—was performed. The Kaplan–Meier's product limit method and chi-square analysis, respectively, assessed overall survival and 30-day (30D) and 90-day (90D) mortalities.Results For 925 patients who had surgery and available mortality data, the 30D and 90D mortality rates were 0.9 and 1.5%. Lower education level (p = 0.0185) and treatment at a nonacademic facility (p = 0.016) were associated with increased risk of 90-day mortality. Median follow-up was 52 months and analysis was dichotomized by histology. For those with skull base chordoma, patients from a larger metro size (p = 0.002), age below the median 52 years (p ≤ 0.001), and private insurance (<0.001) were associated with prolonged survival, whereas for skull base chondrosarcoma, the factors were treatment at an academic medical center (p = 0.001), high-volume center (p = 0.007), age below the median 52 years (p ≤ 0.001), higher income (p = 0.043), higher education (p = 0.017), and private insurance (p ≤ 0.001). Comparing high-, medium-, and low-volume centers, high-volume centers were most likely to be academic, deliver radiotherapy, escalate doses >70 Gy, and utilize proton radiotherapy consistent across both disease subsets.Conclusion Higher educational attainment and treatment at an academic facility were associated with decreased 90D mortality for patients with skull base chordoma and chondrosarcoma. For those with skull base chordoma, larger metro size, younger age, and private insurance were associated with prolonged survival; for those with chondrosarcoma, it was treatment at a high-volume or academic medical center, younger age, higher income or education, and private insurance.
What Are Models of Care? A Systematic Search and Narrative Review to Guide Development of Care Models for Premature Ovarian Insufficiency
Authors: Jones Alicia R. , Tay Chau T. , Melder Angela , Vincent Amanda J. , Teede Helena 
Published: March 2021

AbstractNo specific model of care (MoC) is recommended for premature ovarian insufficiency (POI), despite awareness that POI is associated with comorbidities requiring multidisciplinary care. This article aims to explore the definitions and central components of MoC in health settings, so that care models for POI can be developed. A systematic search was performed on Ovid Medline and Embase, and including gray literature. Unique definitions of MoC were identified, and thematic analysis was used to summarize the key component of MoC. Of 2,477 articles identified, 8 provided unique definitions of MoC, and 11 described components of MoC. Definitions differ in scope, focusing on disease, service, or system level, but a key feature is that MoC is operational, describing how care is delivered, as well as what that care is. Thematic analysis identified 42 components of MoC, summarized into 6 themes—stakeholder engagement, supporting integrated care, evidence-based care, defined outcomes and evaluation, behavior change methodology, and adaptability. Stakeholder engagement was central to all other themes. MoCs operationalize how best practice care can be delivered at a disease, service, or systems level. Specific MoC should be developed for POI, to improve clinical and process outcomes, translate evidence into practice, and use resources more efficiently.
Molecular switch architecture determines response properties of signaling pathways
Authors: Ghusinga Khem Raj , Jones Roger D. , Jones Alan M. , Elston Timothy C. 
Published: March 2021

Significance
Molecular switches are key components of intracellular signal-transduction pathways. Experimental work has established that the activity of molecular switches is regulated by three distinct mechanisms: 1) activation, 2) derepression, and 3) concerted (activation and derepression). However, it remains unclear how the choice of signaling mechanism influences the performance properties of the switch. Here, we characterize each switch design in terms of dose–response relationship, response time, and abilities to process upstream fluctuations. Our results highlight unique features of each mechanism and provide insight into the operating principles that underlie many different signaling pathways.
Context of situation and the role of language
Authors: Bowcher Wendy L. 
Published: March 2021

Abstract
‘Role’ is typically defined according to the part and/or function that something or someone contributes to a
situation. This two-fold perspective is also inherent in discussions of the role of language: the ‘amount’ of language that is
involved in a situation and the ‘function’ of language in a situation, with both perspectives relating to the non-linguistic
systems that may be involved in the conduct of the situation relative to language. It is the latter of these perspectives,
however, that has typically received most attention in discourse analysis, with the former (the ‘amount’) being left implicit and
unproblematised. This paper considers the role of language from various discourse analytical perspectives before critically
examining the concept within Systemic Functional Linguistics. Using system networks as the representational and analytical
platform, the paper redefines ‘role of language’ in contextual Mode as comprised of two sub-systems: degree of
involvement and type of involvement. degree of involvement accounts for the compositional contribution
that language makes in a situation; type of involvement accounts for the way in which language may function in a
situation. Using an illustrative dataset, the paper also demonstrates the effectiveness of the systemic approach in accounting for
overlapping and differing contextual configurations by showing how features within the role of language configure and how
these in turn configure with options in the Field system-network of action. These configurations are essentially hypotheses that can be more comprehensively tested through empirical research.
Autour du Louvre-Lens: An Ambitious Tourism Engineering Project
Authors: Carter Roger , Connolly Gaëlle , Ward-Perkins David , Crozier Norbert 
Published: March 2021

Abstract
Two driving factors underlie this tourism initiative: the decision to create a Louvre satellite museum in the ex-industrial town of Lens and the candidature for UNESCO World Heritage status for the mining area in the Pas-de-Calais region of France. The challenge is how best to develop tourism in an area which has no previous experience or reputation as a tourist destination. ‘Mission Louvre-Lens Tourisme’ was launched in 2010. This case describes the journey in the last decade of developing and implementing the strategy.

Information

Dr Roger Carter and Gaëlle Connolly, adapted from a case study prepared for the OECD manual
Operationalisation of Destinations Management Organisations in Romania
(March 2020)

© CAB International 2021
Final report on SIM.L.K1.2007.1 bilateral comparison (length) 2018-2019: calibration of gauge blocks by optical interferometry
Authors: Álvarez L , Beer E , Giarmana G , Bastida K , Colín C , López A , Villesid M , Eves B 
Published: March 2021

Main text
This bilateral SIM key comparison on calibration of gauge blocks by interferometry (SIM.L-K1.2007.1) was carried out between CENAM (México) and INTI (Argentina). Its scope is to support and maintain the claimed Calibration and Measurement Capability (CMC) by the participants, which regularly offer the service of gauge block calibration by optical interferometry. The comparison was held from first half of 2018 to second half of 2019, and involved the measurement of eleven steel gauge blocks-eight in the range of short gauge block and three in the range of long gauge block. The reference values for each nominal length were taken as the arithmetic mean. The results of both participants are in good agreement with the reference values for all the gauge blocks measured. This makes the present comparison exercise valid to provide evidence of the participants' competence. The results also provides evidence to support the CMC claims of the participants in gauge block calibration by optical interferometry and for those service that stems out of this key technique as required by the CIPM Mutual Recognition Arrangement (CIPM MRA).
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCL, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Key comparison BIPM.RI(I)-K4 of the absorbed dose to water standards of the BEV, Austria and the BIPM in 60Co gamma radiation
Authors: Kessler C , Burns D , Steurer A , Tiefenboeck W , Merza V 
Published: March 2021

Main text
A new key comparison of the standards for absorbed dose to water of the Bundesamt für Eich- und Vermessungswesen (BEV), Austria and the Bureau International des Poids et Mesures (BIPM) was carried out in the 60Co radiation beam of the BIPM in July 2020. The comparison result, based on the calibration coefficients for two transfer standards and evaluated as a ratio of the BEV and the BIPM standards for absorbed dose to water, is 0.9997 with a combined standard uncertainty of 4.1 parts in 103. The result agrees within the uncertainties with the comparison carried out in 2009. The results are analysed and presented in terms of degrees of equivalence, suitable for entry in the BIPM key comparison database.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Final report for supplementary comparison APMP.QM-S14: hazardous air pollutants (HAPs) in nitrogen at 100 nmol/mol
Authors: Lee S , Kang J H , Kim Y D , Kim D H , Zhe B , Wang D , Tshilongo J , Ntsasa N G , Leshabane N , Jozela M , Lekoto G A , Seemane P 
Published: March 2021

Main text
Hazardous air pollutants (HAPs) are toxic air pollutants that are mainly emitted from man-made sources such as chemical processes, automobiles, power plants, and refineries, building materials, and cleaning solvents. Some HAPs are emitted from wildfires and chemical leak. HAPs are regulated and monitored to protect public health and the environment because they cause severe health effects such as cancer, damages to the immune system, reproductive and respiratory health problems.
For this supplementary comparison, a multicomponent mixture of HAPs in nitrogen has been chosen at an amount-of-substance fraction level of 100 nmol mol-1 that is closer to their emission levels from their sources. The supplementary comparison is designed to underpin calibration capabilities using HAPs gas mixtures that are prepared gravimetrically as transfer standards.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
The global potential energy surface of

PH2+(21A′)

extrapolated to the complete basis set limit
Authors: Lü Yanling , Zhang Chengyuan , Ma Hongyu , Guo Qiang , Li Yongqing 
Published: March 2021

Abstract
It has been established that the proton transfer dynamics of

P

+

(

P

3

)

+

H

2

(

X

1

Σ

g

+

)

→
P

H

+

(

A

2

Δ

)

+
H

(

S

2

)

play an important role in determining the chain reaction of phosphorus-containing

P
H

n

+

(

n
=
0
−
4

)

compounds in the planetary ionosphere. This work presents an accurate global potential energy surface (PES) of

P
H

2

+

(

2

1

A

′

)

for the first time by fitting extensive ab initio energies from the aug-cc-pV(T, Q)Z level of theory using the multi-reference configuration interaction method including Davidson correction, and extrapolating the points to the complete basis set limit. The spectral parameters of PH+(A
2Δ) and

H

2

(

X

1

Σ

g

+

)

are shown to be in agreement with the data available in previous literature. Meanwhile, a detailed study of the topographical features of the global PES could be used as a reliable photolytic kinetic theory for the

P

+

(

P

3

)

+

H

2

(

X

1

Σ

g

+

)

reaction. Furthermore, to demonstrate the validity of the new PES, we have explicitly taken into account the

P

+

(

P

3

)

+

H

2

(

X

1

Σ

g

+

)

(

v
=
0
,
j
=
0

)

→
P

H

+

(

A

2

Δ

)

+
H

(

S

2

)

reaction, and assessed its feasibility in terms of reaction dynamics by calculating the integral cross-section via the time-dependent wave packet and quasi-classical trajectory approaches. The consequent results indicate that the new PES is suitable for thermochemical reactions.
Sustainable and homogeneous arc ablation behavior of zirconium cathodes improved by in situ formation of zirconium oxides
Authors: Guan Weimian , Lv Hao , Yuan Jie , Chen Dejiang , Zhu Tao , Fang Youtong , Liu Jiabin , Wang Hongtao , Li Zhihui , Tang Zhigong , Yang Wei 
Published: March 2021

Abstract
Discharge homogeneity is one of the dominant factors affecting cathode lifetime. In this work, the arc ablation behavior of a zirconium cathode is investigated in air and argon atmospheres. Homogeneous discharge processes are observed in air, while poor discharge homogeneity with scattered cathode spots is found in argon. The homogeneous discharge process is related to the layered structure at the discharge center. The surface zirconium oxide layer stabilizes the arc foot and reduces the effective work function. A dual-phase layer underneath, consisting of zirconium oxides and zirconium, enables the transition from the zirconium matrix to the surface oxide layer. The sustainable discharge behaviors are realized by the balance in the cathode, which is created by the ablation of surface zirconium oxides and the oxidization of zirconium in the dual-phase layer.
Force probe simulations using an adaptive resolution scheme
Authors: Oestereich Marco , Gauss Jürgen , Diezemann Gregor 
Published: March 2021

Abstract
Molecular simulations of the forced unfolding and refolding of biomolecules or molecular complexes allow to gain important kinetic, structural and thermodynamic information about the folding process and the underlying energy landscape. In force probe molecular dynamics (FPMD) simulations, one pulls one end of the molecule with a constant velocity in order to induce the relevant conformational transitions. Since the extended configuration of the system has to fit into the simulation box together with the solvent such simulations are very time consuming. Here, we apply a hybrid scheme in which the solute is treated with atomistic resolution and the solvent molecules far away from the solute are described in a coarse-grained manner. We use the adaptive resolution scheme (AdResS) that has very successfully been applied to various examples of equilibrium simulations. We perform FPMD simulations using AdResS on a well studied system, a dimer formed from mechanically interlocked calixarene capsules. The results of the multiscale simulations are compared to all-atom simulations of the identical system and we observe that the size of the region in which atomistic resolution is required depends on the pulling velocity, i.e. the particular non-equilibrium situation. For large pulling velocities a larger all atom region is required. Our results show that multiscale simulations can be applied also in the strong non-equilibrium situations that the system experiences in FPMD simulations.
Point-contact spectroscopy of heavy fermion superconductors Ce2PdIn8 and Ce3PdIn11 in comparison with CeCoIn5
Authors: Yin Lichang , Che Liqiang , Le Tian , Chen Ye , Zhang Yongjun , Lee Hanoh , Gnida Daniel , Thompson Joe D , Kaczorowski Dariusz , Lu Xin 
Published: March 2021

Abstract
We report point-contact spectroscopy measurements on heavy fermion cousins CeCoIn5, Ce2PdIn8 and Ce3PdIn11 to systematically study the hybridization between f and conduction electrons. Below a temperature T*, the spectrum of each compound exhibits an evolving Fano-like conductance shape, superimposed on a sloping background, that suggests the development of hybridization between local f and itinerant conduction electrons in the coherent heavy fermion state below T*. We present a quantitative analysis of the conductance curves with a two-channel model to compare the tunneling process between normal metallic silver particles in our soft point-contact and heavy-fermion single crystals CeCoIn5, Ce2PdIn8 and Ce3PdIn11.
Superconductivity in quasi-2D InTaX2 (X = S, Se) type-II Weyl semimetals
Authors: Adam Mukhtar Lawan , Bala Abba Alhaji 
Published: March 2021

Abstract
Herein, first-principles calculations were employed to study the electronic, topological, and superconducting properties of InTaX2 (X = S, Se). InTaX2 exhibits nodal lines in the absence of spin–orbit coupling (SOC); on SOC inclusion, the nodal lines form Weyl rings with the Weyl points classified as a type-II Weyl semimetal (WSM) with tilted cones. Using Green functions method calculations, surface states distinguishable from the bulk states, and Fermi arcs surface states were visualized on the (001) easily cleavable indium terminated surface of both materials. The electron–phonon calculations using the Allen–Dynes relations predict InTaSe2 and InTaS2 to be superconducting around 2.38 K and 3.25 K. The prediction of these exotic properties in InTaX2 (X = S, Se) makes them suitable for experimental validation of topological superconductivity in type-II WSMs.