bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-Analysis illustrates possible role of lipopolysaccharide (LPS)-induced tissue injury in nasopharyngeal carcinoma (NPC) pathogenesis
Authors: Allen David Z. , Aljabban Jihad , Silverman Dustin , McDermott Sean , Wanner Ross A. , Rohr Michael , Hadley Dexter , Panahiazar Maryam 
Published: October 2021

Background
Nasopharyngeal carcinoma (NPC) is a cancer of epithelial origin with a high incidence in certain populations. While NPC has a high remission rate with concomitant chemoradiation, recurrences are frequent, and the downstream morbidity of treatment is significant. Thus, it is imperative to find alternative therapies.

Methods
We employed a Search Tag Analyze Resource (STARGEO) platform to conduct a meta-analysis using the National Center for Biotechnology’s (NCBI) Gene Expression Omnibus (GEO) to define NPC pathogenesis. We identified 111 tumor samples and 43 healthy nasopharyngeal epithelium samples from NPC public patient data. We analyzed associated signatures in Ingenuity Pathway Analysis (IPA), restricting genes that showed statistical significance (p<0.05) and an absolute experimental log ratio greater than 0.15 between disease and control samples.

Results
Our meta-analysis identified activation of lipopolysaccharide (LPS)-induced tissue injury in NPC tissue. Additionally, interleukin-1 (IL-1) and SB203580 were the top upstream regulators. Tumorigenesis-related genes such as homeobox A10 (HOXA10) and prostaglandin-endoperoxide synthase 2 (PTGS2 or COX-2) as well as those associated with extracellular matrix degradation, such as matrix metalloproteinases 1 and 3 (MMP-1, MMP-3) were also upregulated. Decreased expression of genes that encode proteins associated with maintaining healthy nasal respiratory epithelium structural integrity, including sentan-cilia apical structure protein (SNTN) and lactotransferrin (LTF) was documented. Importantly, we found that etanercept inhibits targets upregulated in NPC and LPS induction, such as MMP-1, PTGS2, and possibly MMP-3.

Conclusions
Our analysis illustrates that nasal epithelial barrier dysregulation and maladaptive immune responses are key components of NPC pathogenesis along with LPS-induced tissue damage.
Clinical and epidemiological characteristics of patients seeking COVID-19 testing in a private centre in Malaysia: Is there a role for private healthcare in battling the outbreak?
Authors: Chow Yock Ping , Chin Brenda Huey Zien , Loo Jin Ming , Moorthy Loshini R. , Jairaman Jamuna , Tan Lian Huat , Tay Wendy Wan Ying 
Published: October 2021

Objective
This cross-sectional observational study summarized the baseline characteristics of subjects who underwent COVID-19 molecular testing in a private medical centre located in the state of Selangor in Malaysia between 1 Oct 2020 and 31 Jan 2021. We compared the baseline characteristics between subjects who were tested positive and negative of SARS-CoV-2 infection, and identified risk factors which may be predictive of SARS-CoV-2 positivity.

Methods and findings
A total of 36603 subjects who were tested for COVID-19 infection via molecular assays at Sunway Medical Centre between Oct 1, 2020 and Jan 31, 2021, and consented to participate in this observation study were included for analysis. Descriptive statistics was used to summarize the study cohort, whereas logistic regression analysis was used to identify risk factors associated with SARS-CoV-2 positivity. Among the reasons listed for COVID-19 screening were those who needed clearance for travelling, clearance to return to work, or clearance prior to hospital admission. They accounted for 67.7% of tested subjects, followed by the self-referred group (27.3%). Most of the confirmed cases were asymptomatic (62.6%), had no travel history (99.6%), and had neither exposure to SARS-CoV-2 confirmed cases (61.9%) nor exposure to patients under investigation (82.7%) and disease clusters (89.2%). Those who presented with loss of smell or taste (OR: 26.91; 95% CI: 14.81–48.92, p<0.001), fever (OR:3.97; 95% CI: 2.54–6.20, p<0.001), running nose (OR: 1.75; 95% CI:1.10–2.79, p = 0.019) or other symptoms (OR: 5.63; 95% CI:1.68–18.91, p = 0.005) were significantly associated with SARS-CoV-2 positivity in the multivariate logistic regression analysis.

Conclusion
Our study showed that majority of patients seeking COVID-19 testing in a private healthcare setting were mainly asymptomatic with low epidemiological risk. Consequently, the average positivity rate was 1.2% compared to the national cumulative positivity rate of 4.65%. Consistent with other studies, we found that loss of smell or taste, fever and running nose were associated with SARS-CoV-2 positivity. We believe that strengthening the capacity of private health institutions is important in the national battle against the COVID-19 pandemic, emphasizing the importance of public-private partnership to improve the quality of clinical care.
Effects on health-related quality of life in the randomized, controlled crossover trial ADIRA (Anti-inflammatory Diet In Rheumatoid Arthritis)
Authors: Turesson Wadell Anna , Bärebring Linnea , Hulander Erik , Gjertsson Inger , Hagberg Lars , Lindqvist Helen M. , Winkvist Anna 
Published: October 2021

Background
Patients with Rheumatoid Arthritis (RA) often report impaired health-related quality of life (HrQoL) such as difficulties in daily life, pain, fatigue and an affected social life. Even when lowering disease activity, pharmacological treatment does not always resolve these factors.

Objective
To investigate if a proposed anti-inflammatory diet improves HrQoL in patients with RA.

Design
In this controlled crossover trial, 50 patients were randomized to start with either an intervention diet (anti-inflammatory) or a control diet (usual Swedish intake) for ten weeks followed by a wash out period before switching to the other diet. Participants received food equivalent to ~1100 kcal/day, five days/week, and instructions to consume similarly for the remaining meals. HrQoL was evaluated using Health Assessment Questionnaire (HAQ), 36-item Short Form Survey (SF-36), Visual Analogue Scales (VAS) for pain, fatigue and morning stiffness, and a time scale for morning stiffness.

Results
Forty-seven participants completed ≥1 diet period and were included in the main analyses. No significant difference between intervention and control diet at end of diet periods was observed for any outcome. However, significant improvements were obtained for SF-36 Physical Functioning (mean:5.79, SE: 2.12, 95% CI: 1.58, 10.01) during the intervention diet period. When excluding participants with anti-rheumatic medication changes, the differences between diet periods increased for most outcomes, favoring the intervention diet period, and the difference for SF-36 Physical Functioning became significant (n = 25, mean:7.90, 95% CI:0.56, 15.24, p = 0.036).

Conclusions
In main analyses, the proposed anti-inflammatory diet did not significantly improve HrQoL for patients with RA compared to control diet. In sub-analyses, significant improvements in physical functioning were detected. Larger studies with consistent medication use and in populations more affected by the disease may be needed to obtain conclusive evidence.
Military Optometry from World War I to the Present
Authors: McAlister W. Howard , Weaver Jeffrey L. , Davis Jerry D. , Newsom Jeffrey A. 
Published: October 2021

Optometry has made significant contributions to the United States military for over a century. Assuring good vision and eye health of soldiers, sailors, airmen and marines is critical to maximizing the military functions necessary to achieve victory. There was little organization or recognition of the profession in World War I, but optometrists were essential in achieving the mission. Recognition of the profession of optometry was still limited in World War II but it was improving, especially with commissioning as officers occurring in the Navy. Through the Korean and Vietnam Wars, optometry grew in stature and strength with all services eventually commissioning all optometrists, and Army optometrists were assigned to combat divisions. Continuing through the more recent conflicts in the middle east, the profession has continued to make an impact and has become an essential part of the armed forces of the United States. Doctors of optometry are now an integral part of the Department of Defense. The nation cannot field an effective fighting force today without the dedicated performance of these officers.
Symmetries of complex analytic vector fields with an essential singularity on the Riemann sphere
Authors: Alvarez-Parrilla Alvaro , Muciño-Raymundo Jesús 
Published: October 2021

Abstract
We consider the family ℰ (s, r, d) of all singular complex analytic vector fields

X
(
z
)
=

Q
(
z
)

P
(
z
)

e

E
(
z
)

∂

∂
z

$X(z)=\frac{Q(z)}{P(z)}{{e}^{E(z)}}\frac{\partial }{\partial z}$

on the Riemann sphere where Q, P, ℰ are polynomials with deg Q = s, deg P = r and deg ℰ = d ≥ 1. Using the pullback action of the affine group Aut(ℂ) and the divisors for X, we calculate the isotropy groups Aut(ℂ)
X
of discrete symmetries for X ∈ ℰ (s, r, d). The subfamily ℰ (s, r, d)id of those X with trivial isotropy group in Aut(ℂ) is endowed with a holomorphic trivial principal Aut(ℂ)-bundle structure. A necessary and sufficient arithmetic condition on s, r, d ensuring the equality ℰ (s, r, d) = ℰ (s, r, d)id is presented. Moreover, those X ∈ ℰ (s, r, d) \ ℰ (s, r, d)id with non-trivial isotropy are realized. This yields explicit global normal forms for all X ∈ ℰ (s, r, d). A natural dictionary between analytic tensors, vector fields, 1-forms, orientable quadratic differentials and functions on Riemann surfaces M is extended as follows. In the presence of nontrivial discrete symmetries Γ < Aut(M), the dictionary describes the correspondence between Γ-invariant tensors on M and tensors on M /Γ.
Image processing algorithms in the assessment of grain damage degree
Authors: Maliga Wojciech , Dudziński Włodzimierz , Łabowska Magdalena , Detyna Jerzy , Łopusiewicz Marcin , Bujak Henryk 
Published: October 2021

AbstractObjectivesThe paper presents preliminary results on the assessment of algorithms used in image processing of the grain damage degree. The purpose of the work is developing a tool allowing to analyse sample cross-sections of rye germs.MethodsThe analysis of the grain cross-sections was carried out on the basis of a series their photos taken at equal time intervals at a set depth. The cross-sections will be used to create additional virtual cross-sections allowing to analyse the whole sample volume. The ultimate plan is to generate two cross-sections perpendicular to each other. Based on volumetric data read from the sample section, a three-dimensional model of an object will be generated.ResultsThe analysis of model surface will allowed us to detect possible grain damage. The developed method of preparing the research material and the proprietary application allowed for the identification of internal defects in the biological material (cereal grains).ConclusionsThe presented methodology may be used in the agri-food industry in the future. However, much research remains to be done. These works should primarily aim at significantly reducing the time-consuming nature of individual stages, as well as improving the quality of the reconstructed image.
Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso
Authors: Zouré Abdou Azaque , Amegnona Lanyo Jospin , Zongo Nayi , Kiendrebeogo Isabelle Touwendpoulimdé , Sorgho Pegdwendé Abel , Zongo Fabienne Ingrid , Yonli Albert Théophane , Sombié Herman Karim , Bambara Aboubacar Hierrhum , Sawadogo Alexis Yobi , Ouedraogo Marie N. L. , Traoré Lassina , Zongo Sidnooma Véronique , Lallogo Doriane Tatiana , Bazié Bapio Valery Jean Télesphore Elvira , Zohoncon Théodora M. , Dijgma Florencia W. , Simpore Jacques 
Published: October 2021

Abstract
Several factors contribute to the development of breast cancer, including the immune system. This study is aimed to characterize the carriage of human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. This case-control study consisted of 96 histologically diagnosed breast cancer cases and 102 controls (cases without breast abnormalities). A multiplex polymerase chain reaction (PCR) was used to characterize the carriage of HLA-DRB1*11 and 1*12 alleles. The HLA-DRB1*11 allele was present in 26.59% of cases and 22.55% of controls. The HLA-DRB1*12 allele was present in 56.63% of cases and 55.88% of controls. This study found no direct association between the carriage of the HLA-DRB1*11 and HLA-DRB1*12 alleles and the occurrence of breast cancer. In addition, the deletion of the HLA-DRB1*11 allele is associated (beneficial effect) with obesity/overweight (OR = 0.13; 95% CI [0.01–1.14]; and p = 0.03) which is a risk for breast cancer. No direct association was found between the carriage of HLA-DRB1*11 and 1*12 alleles and breast cancer risk. However, further investigation of other HLA alleles involved in the occurrence of breast cancer may provide more information.
Characterization of Differentially Expressed miRNAs by CXCL12/SDF-1 in Human Bone Marrow Stromal Cells
Authors: Potter Matthew L. , Smith Kathryn , Vyavahare Sagar , Kumar Sandeep , Periyasamy-Thandavan Sudharsan , Hamrick Mark , Isales Carlos M. , Hill William D. , Fulzele Sadanand 
Published: October 2021

Abstract
Stromal cell-derived factor 1 (SDF-1) is known to influence bone marrow stromal cell (BMSC) migration, osteogenic differentiation, and fracture healing. We hypothesize that SDF-1 mediates some of its effects on BMSCs through epigenetic regulation, specifically via microRNAs (miRNAs). MiRNAs are small non-coding RNAs that target specific mRNA and prevent their translation. We performed global miRNA analysis and determined several miRNAs were differentially expressed in response to SDF-1 treatment. Gene Expression Omnibus (GEO) dataset analysis showed that these miRNAs play an important role in osteogenic differentiation and fracture healing. KEGG and GO analysis indicated that SDF-1 dependent miRNAs changes affect multiple cellular pathways, including fatty acid biosynthesis, thyroid hormone signaling, and mucin-type O-glycan biosynthesis pathways. Furthermore, bioinformatics analysis showed several miRNAs target genes related to stem cell migration and differentiation. This study's findings indicated that SDF-1 induces some of its effects on BMSCs function through miRNA regulation.
L2 Syntactic Alignment in the Reading-Writing Integrated Continuation Task: Evidence From Chinese EFL Learners’ Description of Motion Events
Authors: Wang Min , Gan Qiao , Boland Julie 
Published: October 2021

Abstract
This study investigated how the mode in which the reading-writing integrated continuation task was conducted modulates the effects of second language (L2) syntactic alignment, through the English motion event construction with manner verbs. Ninety Chinese students were assigned to either of the two experimental groups or a control group, and they all experienced a pretest, an alignment phase and a posttest. In the alignment phase, the two experimental groups completed a reading-writing integrated continuation task but in different modes. For the multi-turn mode, participants reconstructed a picture story by continuing the episodes extracted from the story with one episode presented and continued at a time; for the single-turn mode, the first half of the same picture story was presented as a chunk, and then participants read and continued it. Results show that L2 learners aligned with the target structure in completing the story, and the alignment effect was retained in the posttest conducted after a delay of two weeks. Moreover, syntactic alignment was modulated by task mode with the multi-turn group exhibiting stronger immediate and longterm alignment effects. We conclude that the continuation task is a fruitful context for L2 structural alignment, and the magnitude of alignment effect hinges on interactive intensity.
An Alignment-Based Approach to L2 Learning of Chinese Numeral Classifiers
Authors: Wang Chuming , Hong Wei 
Published: October 2021

Abstract
This study investigated the efficiency of learning the Chinese numeral classifiers by L2 Chinese learners by means of an alignment-oriented task. Participants were a total of 96 intermediate learners of L2 Chinese, who were randomly assigned to two experimental groups and one control group, with each group consisting of 32 participants. The continuation task used in this study consisted of a picture-based Chinese text depicting a room with an array of objects, which necessitates the use of classifiers. The two experimental groups were both required to first read the text and then write to describe their own rooms in comparison with the one in the text. One group was instructed to use the classifiers from the text as much as possible in their writing, whereas the other was not required to do so. Participants in the control group were first given the picture to look at in the absence of the text and then asked to describe their own rooms. The results showed that the continuation task significantly enhanced participants’ retention of the Chinese numeral classifiers, suggesting that the alignment-based approach is an effective way to learn difficult linguistic categories such as the Chinese classifiers.
Creative Imitation: An Answer to the Fundamental Issue of L2 Learning
Authors: Zhou Xiao 
Published: October 2021

Abstract
This paper reports on a study on the effects of reading-writing integrated tasks on vocabulary learning and explored the differential roles of creative construction and non-creative construction in promoting lexical learning. Participants were 90 first-year English majors, randomly assigned to two experimental groups (continuation and retelling) and one control group, with 30 students in each group. Results showed that the continuation group generated a substantial amount of creative construction and produced significantly more instances of creative imitation than the retelling group. The continuation group outperformed the retelling group for both receptive and productive vocabulary knowledge gain and retention, but differences were only significant in terms of productive vocabulary retention. Finally, productive vocabulary knowledge retention among the continuation group was significantly and positively correlated with creative imitation (meaning creation coupled with language imitation), but not with linguistic alignment per se. As productive vocabulary knowledge constitutes the learner ’ s ability to use lexical knowledge to express ideas in dynamic contexts, the findings afforded evidence that creative imitation could be the answer to the fundamental issue of L2 learning (i.e., mapping static language onto dynamic idea expression). The pedagogical implications as well as future research directions are also discussed.
The Construct of the Story Continuation Writing Task: Insights From the China’s Standards of English Language Ability
Authors: Ye Wei , Ren Wei , Zheng Shan 
Published: October 2021

AbstractAlthough the story continuation writing task (SCWT) has attracted much research attention, few studies have investigated the construct of the task, particularly with respect to which language competence it focuses on. In addition, although some studies have demonstrated that China’s Standards of English Language Ability (CSE) provides comprehensive insights into the development of Chinese learners’ English language proficiency, little research has investigated the relationship between CSE and SCWT. This study drew upon the CSE to develop an SCWT language use inventory to address the above research gaps. A total of 358 high school students were asked to complete the questionnaire, of which 277 valid responses were analyzed. Exploratory factor analysis (EFA) on the CSE-based questionnaire revealed the presence of six factors, namely language correctness, language variety, task planning, connecting-and-generating, selecting-and-mining, and organizing. The strategy of connecting-and-generating was the only significant predictor of the learners’ SCWT scores. The paper also discusses the findings relating to the SCWT rating and other integrated writing tasks.
Understanding Le Châtelier’s principle fundamentals: five key questions
Authors: Peris Miguel 
Published: October 2021

Abstract
The well-known Le Châtelier’s principle is almost always mentioned when dealing with chemical equilibrium. Nevertheless, although a must in most general chemistry courses starting from the secondary level, when students face questions about it, some major misconceptions are often highlighted; to avoid this, a somewhat challenging problem is now presented. It can be deemed a very useful tool for a full understanding of this principle and chemical equilibrium as a whole. A generic chemical reaction at equilibrium is subject to different types of perturbation, and the student is required – in each case – to identify the new position of equilibrium among a number of proposals. The correct answers are finally provided along with the corresponding explanations.
The Emblem Texts at Tådene, Västergötland
Authors: McKeown Simon 
Published: October 2021

Abstract
The church of Tådene in Västergötland is home to a series of painted panels dating from the early 1700s. Before their restitution to the church in the 1960s, the panels were stored in a mausoleum, putting them beyond the scrutiny of scholars. This obscurity helped conceal the fact that the panels constitute the most sophisticated surviving programme of emblems to be found in any church in Sweden, remarkable in scale, scope, and invention. This article presents for the first time the source of the emblems at Tådene, and argues that a factor in the programme’s success is the role played in the composition of the poetic texts added to the emblems, and that, moreover, the author of these interventions was one of Sweden’s leading literary figures of the Baroque, Johan Runius. Not only was Runius resident in the parish of Tådene at the time when these panels took form, but his literary production in these years mark his only known attempts at the emblem genre. Through the confluence of date, place, and style, the article suggests that the texts of Tådene’s emblems merit investigation as lost poems dating from an early stage of Runius’s short career.
Dänemark – Hollywood – Europa
Authors: Hochscherf Tobias 
Published: October 2021

Abstract
Thomas Vinterberg is one of Scandinavia’s well-respected contemporary directors. His career is best noted for his involvement in the launch of the Dogma 95 Manifesto and it was his acclaimed Festen (DK 1998) that started the prolific film movement that followed. Yet, as this article shows, Vinterberg repeatedly tried to reinvent himself as an artist, taking on different genres, themes and aesthetic approaches. When his all-star science fiction film It’s All about Love (2003) and his pan-European co-productions met with the disapproval of critics and audiences alike, he returned to realist films. The subsequent success of his dramas – including Submarino (2010), Jagten (2012) and Druk (2020) – reinstated his status of an auteur filmmaker. The three films share a number of continuities, including a penchant for themes of homecoming, dysfunctional family relations and everyday socio-cultural conflicts within the limits of close-knit communities or circles of friends.