bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ankle Ligament Reconstruction-Return to Sport After Injury (ALR-RSI) Scale and Return to Sports After Ankle Ligament Reconstruction or Repair – A Systematic Review
Authors: Wang YuChia , Hinz Maximilian , Buchalter Wyatt H. , Drumm Amelia H. , Eren Emre A. , Haytmanek C. Thomas Thomas , Backus Jonathon D. 
Published: December 2024

Category: Ankle; Sports Introduction/Purpose: While objective outcome measures assessing foot and ankle function are well established to determine return to sport (RTS) following ankle injuries, psychological factors have been recognized in recent years to be equally important. The Return to Sport after Injury (RSI) scale has become an emergingly useful tool used in assessing psychological readiness to return to sporting activity after various pathologies and their treatment. The Ankle Ligament Reconstruction-Return to Sport after Injury (ALR-RSI) scale is a novel questionnaire and scoring system for the evaluation of psychological readiness to return to sport following lateral ankle ligament reconstruction or repair. Purpose: To systematically review existing literature regarding the ALR-RSI scale and to assess its correlation with RTS and functional outcomes as well as feasibility, reliability, and consistency. Methods: A systematic review of the literature based on the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) was conducting using PubMed, Embase and Cochrane Library. Studies that evaluated psychological readiness after ankle ligament reconstruction or repair for the treatment of chronic lateral ankle instability using the ALR-RSI scale were included. The results from each study were pooled, and weighted means and overall rates were calculated. Results: In total, 157 patients (53.2% male, mean age: 34.2 years) from 3 articles were included. Overall, 85.0% of patients reported successful RTS, but only 48.9% of patients returned to the preoperative sporting level. All studies reported a significant difference in psychological scores between patients who returned to sport and those who didn’t. The pooled mean functional outcome measures, reported as the American Orthopaedic Foot and Ankle Society Ankle-Hindfoot (AOFAS) Score and Karlsson-Peterson Score, were 82.7 (range, 29-100) and 81.7 (range, 25-100), respectively. The ALR-RSI scale demonstrated strong correlations with the AOFAS Score and Karlsson-Peterson Score. Conclusion: Patients who RTS after ankle ligament reconstruction or repair exhibited higher psychological readiness compared to those who didn’t return to sport. The ALR-RSI scale showed strong correlations with ankle function. Evaluation of psychological readiness using the ALR-RSI scale may provide an additional tool in the rehabilitation process of athletes that aim to assess RTS after ankle ligament reconstruction or repair.
Mitochondrial uncoupling protein 2: a central player in pancreatic disease pathophysiology
Authors: Wang Kunpeng , Zhang Lilong , Deng Beiying , Zhao Kailiang , Chen Chen , Wang Weixing 
Published: December 2024

AbstractPancreatic diseases pose considerable health challenges due to their complex etiology and limited therapeutic options. Mitochondrial uncoupling protein 2 (UCP2), highly expressed in pancreatic tissue, participates in numerous physiological processes and signaling pathways, indicating its potential relevance in these diseases. Despite this, UCP2’s role in acute pancreatitis (AP) remains underexplored, and its functions in chronic pancreatitis (CP) and pancreatic steatosis are largely unknown. Additionally, the mechanisms connecting various pancreatic diseases are intricate and not yet fully elucidated. Given UCP2’s diverse functionality, broad expression in pancreatic tissue, and the distinct pathophysiological features of pancreatic diseases, this review offers a comprehensive analysis of current findings on UCP2’s involvement in these conditions. We discuss recent insights into UCP2’s complex regulatory mechanisms, propose that UCP2 may serve as a central regulatory factor in pancreatic disease progression, and hypothesize that UCP2 dysfunction could significantly contribute to disease pathogenesis. Understanding UCP2’s role and mechanisms in pancreatic diseases may pave the way for innovative therapeutic and diagnostic approaches.
Graphical Abstracts
BTF3 affects hepatocellular carcinoma progression by transcriptionally upregulating PDCD2L and inactivating p53 signaling
Authors: Kong Minyu , Shi Xiaoyi , Gao Jie , Guo Wenzhi 
Published: December 2024

AbstractHepatocellular carcinoma (HCC) is one of the most common malignant tumors, with the characteristics of high mortality and low 5-year survival rate. The potential role of BTF3 and PDCD2L in HCC remains unclear. Our study found that BTF3 expression was upregulated in hepatocellular carcinoma tissues, and its high expression was associated with poor prognosis. Knockdown of BTF3 significantly inhibited proliferation and promoted apoptosis of hepatocellular carcinoma cells by cell function assay. Mechanistically, BTF3 plays an oncogenic role by regulating the transcriptional expression of PDCD2L, which promotes proliferation and inhibits apoptosis of HCC cells by restraining the p53 pathway. In conclusion, our results suggest that BTF3 induces malignant progression of HCC by acting as a transcription factor that promotes the transcription of PDCD2L and influences the p53 pathway and that the BTF3/PDCD2L/P53 axis may be a future therapeutic strategy for HCC patients.
A Pressure-Bearing Microwave Transmission Line for Rapid Energy-Efficient Manufacturing Systems of High-End Composite Parts
Authors: Zhou Jing , Li Yingguang , Zhu Zexin , Qi Xunyi , Hao Xiaozhong 
Published: December 2024

Abstract
Currently, a 2-port microwave transmission line with a glass window is usually used to transmit microwave energy to a pressure vessel while sealing the high-pressure gas. In this situation, the damage of the brittle glass window will inevitably result in disastrous accidents. In this paper, the idea of a “2+4”-port microwave transmission line is first proposed to solve this problem. A 4-port waveguide bridge structure is connected to the input port of a traditional 2-port structure, which can release the high-pressure gas safely when the glass window of the 2-port microwave transmitting structure fails. To test this idea, a “2+4”-port microwave transmission line at 2.45 GHz was designed and fabricated. The effectiveness of the whole system in microwave transmission was validated by both simulations and experiments. A high microwave transmittance of more than 97% in the simulation and 91% in the experiment was achieved. The long-time transmission of 15-kW microwave energy, 5 times higher than the previous work, was realized. Moreover, the effectiveness of the transmission line in releasing high-pressure gas (0.6 MPa) was validated by a series of fluid-structure interaction simulations. This research proposes a new transmission structure for transmitting microwave into a pressurized environment safely and efficiently, which can be promoted to a series of applications including vacuum electron devices, microwave ovens, and so on.
Current trends in the medial side of the knee: not only medial collateral ligament (MCL)
Authors: Lucidi Gian Andrea , Solaro Luca , Grassi Alberto , Alhalalmeh Mohammad Ibrahim , Ratti Stefano , Manzoli Lucia , Zaffagnini Stefano 
Published: December 2024

AbstractThe medial collateral ligament (MCL) is by far the most commonly injured ligament of the knee. The medial ligament complex covers a broad bony surface on the extraarticular portion of the femur and is highly vascularized, which allows for a high healing potential. For this reason, most MCL complex lesions were treated conservatively in the past. However, recent advancements regarding the MCL anatomy and kinematics highlighted the complex biomechanical behavior of the isolated and combined MCL lesion, and it is now fully appreciated that some MCL lesions warrant surgical treatment. The present review aims to provide the reader with an overview of the new evidence and advancement on the complex anatomy, biomechanics, and treatment of the MCL.
Comparative transcriptomes and WGCNA reveal hub genes for spike germination in different quinoa lines
Authors: Huang Liubin , Zhang Lingyuan , Zhang Ping , Liu Junna , Li Li , Li Hanxue , Wang Xuqin , Bai Yutao , Jiang Guofei , Qin Peng 
Published: December 2024

Abstract
Background
Quinoa, as a new food crop, has attracted extensive attention at home and abroad. However, the natural disaster of spike germination seriously threatens the quality and yield of quinoa. Currently, there are limited reports on the molecular mechanisms associated with spike germination in quinoa.

Results
In this study, we utilized transcriptome sequencing technology and successfully obtained 154.51 Gb of high-quality data with a comparison efficiency of more than 88%, which fully demonstrates the extremely high reliability of the sequencing results and lays a solid foundation for subsequent analysis. Using these data, we constructed a weighted gene co-expression network (WGCNA) related to starch, sucrose, α-amylase, and phenolic acid metabolites, and screened six co-expression modules closely related to spike germination traits. Two of the modules associated with physiological indicators were analyzed in depth, and nine core genes were finally predicted. Further functional annotation revealed four key transcription factors involved in the regulation of dormancy and germination processes: gene LOC110698065, gene LOC110696037, gene LOC110736224, and gene LOC110705759, belonging to the bHLH, NF-YA, MYB, and FAR1 gene families, respectively.

Conclusions
These results provide clues to identify the core genes involved in quinoa spike germination. This will ultimately provide a theoretical basis for breeding new quinoa varieties with resistance.
Benefits of early MR-Imaging in patients with acute spontaneous intracerebral hemorrhage: a retrospective study
Authors: Grund Benedikt , Ebert Anne , Sandikci Vesile , Neumaier-Probst Eva , Alonso Angelika 
Published: December 2024

Abstract
Background
Neuroimaging plays a vital role in the diagnosis of intracerebral hemorrhage (ICH) and in identifying the underlying etiology for appropriate therapeutic approach. This study aims to determine the significance and potential advantages of using early magnetic resonance imaging (MRI) as a diagnostic tool for ICH.

Methods
This retrospective study included 359 patients with ICH treated at the Department of Neurology, Mannheim University Hospital between January 2017 and December 2021. Patient characteristics, stroke severity and imaging procedures were descriptively analyzed. Factors associated with the choice of imaging modalities were evaluated. The etiology of hemorrhage was retrospectively analyzed using the existing data. We recorded the reassignment of ICH etiology by comparing the assessment after first sole review of CT scan and then subsequent MRI review. The overall rate of reassignments and the reassignments per CT-based initial etiology were analyzed.

Results
In the sample of 359 patients with ICH (mean age 73.1 years, 55.4% male), patients receiving an additional MRI were significantly younger (p < .001) and were less severely affected by stroke (median NIHSS score 5 vs. 15, p < .001). MRI was performed significantly less frequently in patients who died during hospitalization (11.7% vs. 63.9%, p < .001). MRI led to a reassignment of ICH etiology in 48.2% of cases (80/166), uncovering unknown underlying causes in 69% of cases (49/71). Reassignment occurred most frequently in patients with a CT-based diagnosis of hypertensive ICH (18/50). The most frequent reassigned etiologies after MR imaging were cerebral amyloid angiopathy (CAA; 36 patients) and secondary hemorrhage of an ischemic stroke (30 patients).

Conclusions
Early MR imaging in patients with ICH improves the determination of underlying etiology and the conception of an appropriate treatment approach, potentially contributing to better patient outcomes.
Multidisciplinary approach to occlusal rehabilitation in a patient with true hemifacial hyperplasia and temporomandibular joint ankylosis: a case report
Authors: Choi Eun-Hack Andrew , Bae Jun-Hyeong , Lee Seeyoon , Kim Jee Hwan , Nguyen Loi Phuoc , Kim Jun-Young , Choi Sung-Hwan 
Published: December 2024

Abstract
Background
This case report details a true hemifacial hyperplasia with temporomandibular joint ankylosis case managed through a multidisciplinary approach involving department of oral and maxillofacial surgery, orthodontics, and prosthodontics.

Case presentation
A 42-year-old female patient presented with a chief complaint of limited mouth opening. Clinically, the patient exhibited severe facial asymmetry due to hyperplasia of the left facial region. Cone-beam computed tomography findings revealed overgrowth of the left mandible, zygomatic bone, and maxillary bone including alveolar bone, along with bony ankylosis of the temporomandibular joint. To alleviate the restricted mouth opening, gap arthroplasty was initially performed. Additionally, alveoloplasty was carried out to address occlusal interference caused by the overgrown alveolar bone. Orthodontic treatment was conducted to reduce mandibular molar width and achieve proper overjet. For reconstruction of the left side occlusion, dental implants were placed using an implant surgical guide, followed by prosthetic rehabilitation. Total treatment duration was 48 months, resulting in stabilization of the patient’s occlusion.

Conclusion
By setting feasible goals through consultations among specialists from each department, based on three-dimensional simulations, successful and efficient occlusal rehabilitation can be achieved in a true hemifacial hyperplasia patient.
Experiences, attitudes, and knowledge of medical students regarding intellectual and developmental disability: a Canadian study
Authors: Tarzi Gabriel , Yip Alyssa , Jiwa Muhammad Irfan , Thakur Anupam , Mishra Soumya , Koch Laura , Mendoza Olivia , Perera Amandi , Mckenzie Lachina , Lunsky Yona 
Published: December 2024

Abstract
Background
As the healthcare of individuals with intellectual and developmental disabilities (IDD) shifts toward community-based services, physicians in all areas of medicine are more likely to care for this population. To ensure that all physicians can provide high-quality care to people with IDD, further understanding and attention to undergraduate medical education related to IDD is needed.

Methods
A 24-item survey assessed the experiences, attitudes, knowledge, skills, and future interest of Canadian medical students regarding IDD. Descriptive statistics were calculated for questionnaire responses and responses of students who had more in-depth experience were compared to those of students with minimal past experience.

Results
A total of 443 Canadian medical students completed the survey. Students did not feel competent obtaining clear histories from people with IDD. Most students were not confident they could provide quality care to this population but wanted further learning. Students with prior IDD experiences through family/friends felt more knowledgeable and interested in caring for this population than those with community/clinical and minimal experiences.

Discussion
Many Canadian medical students lack the knowledge and skills needed to adequately care for people with IDD. Despite this, a majority of students were interested in further learning opportunities to improve care for people with IDD. These findings underscore the necessity of evaluating the current medical curriculum and implementing measures to better prepare students to care for this population.
Which psychological needs profile exhibits higher engagement and favorable attitudes toward interprofessional education? A cluster analysis among health and social care Hong Kong students
Authors: Dizon John Ian Wilzon T. , He Qing , Shen Xiaoai , Luk Pauline , Chong Doris Yin Kei , Chan Karen Man Kei , Chan Chad Wing Nga , Chan Sarah So Ching , Choy Jacky Chak Pui , Lam Chor Yin , Lee Diana Pui Ling , Manio Michael Magtoto , Ng Zoe Lai Han , Ng Terry Tin Wai , Orlu Mine , Sit Cecilia Tin Yan , Szeto Grace Pui Yuk , Yuen Jacqueline Kwan Yuk , Tipoe George L. , Ganotice Fraide A. 
Published: December 2024

Abstract
Background
This study aimed to investigate which basic psychological needs profile, based on different levels of autonomy, competence, and relatedness, could exhibit higher student engagement and favorable attitudes toward interprofessional education (IPE).

Methods
A total of 341 undergraduate and postgraduate health and social care students enrolled in an IPE simulation participated in this study. Data were analyzed using a person-centered approach using a two-step cluster analysis, multiple analysis of variance, and bootstrapped independent t-tests. The participants completed the self-report scales such as the basic psychological needs in general questionnaire, interprofessional attitudes scale, and engagement versus disaffection with learning scale.

Results
Two basic psychological needs profiles emerged from the cluster analysis: a high basic psychological needs profile (i.e., high autonomy, moderately high competence, and very high relatedness) and a low basic psychological needs profile (i.e., low autonomy, moderately low competence, and very low relatedness). Students with high basic psychological needs profiles (n = 140; 41%) had more positive attitudes about IPE and were more behaviorally and emotionally engaged in participating in IPE tasks than students with low basic psychological needs profiles (n = 201; 59%).

Conclusions
Findings suggest that health and social care students’ engagement and attitudes toward interprofessional education differed based on their basic psychological needs profiles. Health professions educators can leverage students’ basic psychological needs in designing interventions and simulation activities to promote students’ engagement and collaborative outcomes in IPE. Enhancing students’ basic psychological needs could be crucial in fostering greater behavioral and emotional engagement and positive attitudes in participating in IPE.
Tracing the transmission of carbapenem-resistant Enterobacterales at the patient: ward environmental nexus
Authors: Elton Linzy , Williams Alan , Ali Shanom , Heaphy Jelena , Pang Vicky , Commins Liam , O’Brien Conor , Yetiş Özge , Caine Estelle , Ward Imogen , Muzslay Monika , Yui Samuel , Karia Kush , Shore Ellinor , Rofael Sylvia , Mack Damien J. F. , McHugh Timothy D. , Wey Emmanuel Q. 
Published: December 2024

Abstract
Introduction
Colonisation and infection with Carbapenem-resistant Enterobacterales (CRE) in healthcare settings poses significant risks, especially for vulnerable patients. Genomic analysis can be used to trace transmission routes, supporting antimicrobial stewardship and informing infection control strategies. Here we used genomic analysis to track the movement and transmission of CREs within clinical and environmental samples.

Methods
25 isolates were cultured from clinical patient samples or swabs, that tested positive for OXA-48-like variants using the NG-Test® CARBA-5 test and whole genome sequenced (WGS) using Oxford Nanopore Technologies (ONT). 158 swabs and 52 wastewater samples were collected from the ward environment. 60 isolates (matching clinical isolate genera; Klebsiella, Enterobacter, Citrobacter and Escherichia) were isolated from the environmental samples using selective agar. Metagenomic sequencing was undertaken on 36 environmental wastewater and swab samples.

Results
21/25 (84%) clinical isolates had > 1 blaOXA gene and 19/25 (76%) harboured > 1 blaNDM gene. Enterobacterales were most commonly isolated from environmental wastewater samples 27/52 (51.9%), then stick swabs 5/43 (11.6%) and sponge swabs 5/115 (4.3%). 11/60 (18%) environmental isolates harboured > 1 blaOXA gene and 1.9% (1/60) harboured blaNDM-1. blaOXA genes were found in 2/36 (5.5%) metagenomic environmental samples.

Conclusions
Potential for putative patient-patient and patient-ward transmission was shown. Metagenomic sampling needs optimization to improve sensitivity.
Disutility associated with social isolation and loneliness in Germany: results of a population survey using the EQ-5D-5L instrument
Authors: König Hans-Helmut , Hajek André 
Published: December 2024

Abstract
Background
Social isolation and loneliness are highly prevalent and may have a negative impact on health-related quality of life (HRQL). The EQ-5D-5L is a widely used questionnaire from which an index value for HRQL based on societal preferences (utility) can be derived. The purpose of this study was to estimate the loss in utility (i.e. disutility) associated with loneliness and social isolation in the German adult population.

Methods
Data came from a quota sample of individuals aged 18–74 years residing in Germany (n = 5,000) and representing the adult population in terms of age groups, gender and geographic locations. Data collection was conducted online in August and September 2023 by a certified market research firm. The EQ-5D-5L index score based on the German value set was used as outcome. Moreover, the established Lubben Social Network Scale was used to measure social isolation. The De Jong Gierveld tool was used to quantify loneliness. Groups affected by social isolation or loneliness were compared to non-affected groups, respectively. Differences in covariates between affected and non-affected groups were balanced using entropy balancing. Linear regressions were conducted afterwards (using the weights derived from the entropy balancing). Subgroup analyses by sex and age groups as well as various robustness checks were conducted.

Results
The EQ-5D-5L index score was lower among individuals with social isolation compared to individuals without social isolation (β=-0.04, p < 0.001). Moreover, the EQ-5D-5L index score was lower among individuals with loneliness compared to individuals without loneliness (β=-0.07, p < 0.001). Several robustness checks produced similar results. The findings were almost the same for both women and men and varied only slightly between age groups.

Conclusions
We found a statistically significant and relevant disutility associated with social isolation and, even more pronounced, with loneliness. The magnitude of disutilities is similar to those reported for various chronic diseases. Taking into account the high prevalence of social isolation and, in particular, loneliness, the associated burden in terms of quality-adjusted life years (QALY) lost is likely to be tremendous. The results underline the need to take action against the high prevalence of loneliness and social isolation.