bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable edible packaging systems based on active compounds from food processing byproducts: A review
Authors: Hamed Imen , Jakobsen Anita Nordeng , Lerfall Jørgen 
Published: December 2021

AbstractThe global food processing industries represent a challenge and a risk to the environment due to the poor handling of residues, which are often discarded as waste without being used in further sidestreams. Although some part of this biomass is utilized, large quantities are, however, still under‐ or unutilized despite these byproducts being a rich resource of valuable compounds. These biowastes contain biopolymers and other compounds such as proteins, polysaccharides, lipids, pigments, micronutrients, and minerals with good nutritional values and active biological properties with applications in various fields including the development of sustainable food packaging.This review offers an update on the recent advancement of food byproducts recycling and upgrading toward the production of food packaging materials, which could be edible, (bio)degradable, and act as carriers of biobased active agents such as antimicrobials, antioxidants, flavoring additives, and health‐promoting compounds. This should be a global initiative to promote the well‐being of humans and achieve sustainability while respecting the ecological boundaries of our planet.Edible films and coatings formulations based on biopolymers and active compounds extracted from biowastes offer great opportunities to decrease the devastating overuse of plastic‐based packaging. It has become evident that a transition from a fuel‐based to a circular bio‐based economy is potentially beneficial. Therefore, the exploitation of food discards within the context of a zero‐waste biorefinery approach would improve waste management by minimizing its generation, reduce pollution, and provide value‐added compounds. Most importantly, the development of edible packaging materials from food byproducts does not compete with food resources, and it also helps decrease our dependency on petroleum‐based products.Practical Application Almost 99% of current plastics are petroleum‐based, and their continuous use has been devastating to the planet as plastic‐derived components have been detected in all trophic levels. Besides, the increasing amounts of food by‐products are a socioeconomic and environmental challenge, and halving food loss and waste and turning it into valuable products has become necessary to achieve sustainability and economic circularity. The development of new packaging systems such as edible materials could be one of the solutions to limit the use of persistent plastics. Edible films and coatings by‐products‐based could also enhance food packaging performance due to their compounds' bioactivities.
Binge drinking and sexual risk behavior among US sexual and gender minority college students
Authors: Li Jason J. , Hyun Sunah , Stevens Courtney , Chen Justin A. , Liu Cindy H. 
Published: December 2021

AbstractBackground and ObjectivesBinge drinking and sexual risk behaviors have historically been associated with lesbian, gay, bisexual, and transgender (LGBT) adults; however, few studies have described this association among broader sexual and gender minority (SGM) students, who often identify outside of LGBT (e.g., asexual, queer). This study examined the relationship between binge drinking and sexual risk behaviors among SGM versus non‐SGM college students.MethodsA retrospective analysis was conducted with cross‐sectional data from the Spring 2017 American College Health Association‐National College Health Assessment (ACHA‐NCHA) survey among US undergraduates (n = 47,821) across 92 institutions. Binge drinking was measured as more than five drinks consumed the last time the student socialized; sexual risk behavior was measured as the number of sexual partners in the past 12 months.ResultsNumerous undergraduates nationally identify as SGM (19.9%), with bisexual (32.7%), other SGM (26.1%), and asexual (25.4%) students comprising the largest subgroups. Prevalent among both SGM (28.1%) and non‐SGM (29.6%) students, binge drinking had a significant main effect on the number of sexual partners. A significant interaction effect was observed between SGM identity and binge drinking on the number of sexual partners, such that this association was stronger in SGM versus non‐SGM students. This effect remained significant across multiple SGM subgroups.Discussion and ConclusionsSGM students are more prevalent and diverse than previously reported. While prevalent overall, binge drinking may be uniquely sexualized among SGM students.Scientific SignificanceIn the first large‐scale study assessing drinking among disaggregated SGM college students, data suggest tailoring alcohol interventions to SGM students, particularly those identifying outside of LGBT.
The entanglement of time and cost deviations in public projects
Authors: Catalão Francisco Pinheiro , Cruz Carlos Oliveira , Sarmento Joaquim Miranda 
Published: December 2021

AbstractThere is growing concern regarding cost and time overruns in public projects. However, despite the extensive literature on the subject, there is relatively little research on the impact of time overruns on cost overruns. This study assesses whether larger time deviations can lead to larger cost deviations. Our hypothesis is that a project with a time overrun is more likely to also have a cost overrun. The authors used a sample of 208 projects in Portugal, with data collected from the Portuguese Court of Auditors. Using the data, a number of econometric models were developed: Ordinary Least Squares, Generalized Linear Model, Tobit, and Probit. The instrumented variables and structural equation modelling techniques were applied to address potential endogeneity in the data. The analysis was controlled for factors such as political, governance, economic, and project variables. The results suggest that larger time deviations are associated with larger cost deviations. The inference is that projects that take longer to complete also tend to suffer from cost overruns.
Letter: proton pump inhibitors and risk of myocardial infarction
Authors: Zheng Xueyang , Li Na , Zhao Jian 
Published: December 2021

LINKED CONTENTThis article is linked to Nolde et al papers. To view these articles, visit https://doi.org/10.1111/apt.16565 and https://doi.org/10.1111/apt.16684
Editorial: delving into the natural history of Crohn’s disease and the impact of medical therapy—authors' reply
Authors: Burisch Johan , Langholz Ebbe , Munkholm Pia 
Published: December 2021

LINKED CONTENTThis article is linked to Burisch et al papers. To view these articles, visit https://doi.org/10.1111/apt.16615 and https://doi.org/10.1111/apt.16640
Letter: hepatic steatosis in chronic hepatitis B—viral, metabolic or treatment‐related?
Authors: Morozov Sergey , Batskikh Sergey 
Published: December 2021

LINKED CONTENTThis article is linked to Zheng et al papers. To view these articles, visit https://doi.org/10.1111/apt.16595 and https://doi.org/10.1111/apt.16715
Editorial: the three tenors in HBV—TDF, TAF and now TMF. Authors' reply
Authors: Liu Zhihong , Liu Ziyang , Xiao Ling , Niu Junqi , Hou Jinlin 
Published: December 2021

LINKED CONTENTThis article is linked to Liu et al papers. To view these articles, visit https://doi.org/10.1111/apt.16611 and https://doi.org/10.1111/apt.16668
Editorial: the role for PIVKA‐II measurement after HCV elimination by direct‐acting anti‐virals in terms of prediction of hepatocellular carcinoma
Authors: Ogawa Eiichi 
Published: December 2021

LINKED CONTENTThis article is linked to Degasperi et al papers. To view these articles, visit https://doi.org/10.1111/apt.16685 and https://doi.org/10.1111/apt.16710
Letter: hepatic steatosis and fibrosis in chronic hepatitis B—the chicken‐and‐egg conundrum. Authors' reply
Authors: Zheng Qi , Nguyen Mindie H. 
Published: December 2021

LINKED CONTENTThis article is linked to Zheng et al papers. To view these articles, visit https://doi.org/10.1111/apt.16595 and https://doi.org/10.1111/apt.16678
Editorial: the role for PIVKA‐II measurement after HCV elimination by direct‐acting antivirals in terms of prediction of hepatocellular carcinoma—authors' reply
Authors: Degasperi Elisabetta , D’Ambrosio Roberta , Lampertico Pietro 
Published: December 2021

LINKED CONTENTThis article is linked to Degasperi et al papers. To view these articles, visit https://doi.org/10.1111/apt.16685 and https://doi.org/10.1111/apt.16696
Ustekinumab levels in pregnant women with inflammatory bowel disease and infants exposed in utero
Authors: Flanagan Emma , Prentice Ralley , Wright Emily K. , Gibson Peter R. , Ross Alyson L. , Begun Jakob , Sparrow Miles P. , Goldberg Rimma , Rosella Ourania , Burns Megan , Kiburg Katerina V. , Bell Sally J. 
Published: December 2021

SummaryBackgroundUstekinumab is increasingly used in pregnant women with inflammatory bowel disease (IBD). Existing safety data are reassuring, but the stability of ustekinumab levels in pregnancy, degree of transfer to the infant and time to infant clearance are unknown.MethodsIn this prospective observational study, ustekinumab‐exposed women with IBD had trough levels measured in each trimester of pregnancy and at delivery. Infant ustekinumab levels were measured at delivery and ongoing until clearance was achieved. Trough ustekinumab level stability in individuals across pregnancy was compared by Skillings‐Mack test. Spearman coefficients were used to correlate maternal and infant delivery levels, and median time to infant ustekinumab clearance was defined.Results19 pregnant women receiving ustekinumab were included. There was no difference in ustekinumab levels across pregnancy in those with two or more representative trough levels (P = 0.83, n = 11). Infant delivery ustekinumab levels were higher than maternal levels, with a median infant:maternal ratio of 1.79 (IQR 1.26‐3.1). There was a positive correlation between maternal and infant delivery ustekinumab levels (r = 0.75, P = 0.001) and an inverse correlation between the number of days from final antenatal dose and delivery infant ustekinumab level (r = −0.65, P = 0.006). Median time of infant ustekinumab clearance was 9 (range 6‐19) weeks (n = 9).ConclusionUstekinumab drug levels appear stable in pregnancy, with a delivery infant:maternal ratio similar to that of anti‐TNFs. Infant ustekinumab clearance was complete by 20 weeks post‐partum, however, infants exposed in utero should avoid live vaccination before 12 months of age until further clearance data are obtained.
Long‐term outcomes in corticosteroid‐refractory Graves' orbitopathy treated with tocilizumab
Authors: Moi Laura , Hamedani Mehrad , Ribi Camillo 
Published: December 2021

AbstractBackgroundUp to 20% of patients with moderate to severe Graves' orbitopathy (GO) do not respond to high‐dose glucocorticoids (GC). A few studies, including a randomized trial, have demonstrated the efficacy of interleukin‐6 (IL‐6) blockade with tocilizumab (TCZ) in GC‐refractory GO. However, data on predictors of response to TCZ and long‐term outcomes are lacking.MethodsObservational single‐center study on ten consecutive patients treated with TCZ for GC‐refractory GO, between 2016 and 2020. Median (interquartile range) follow‐up was 24 (12–36) months.ResultsInflammation and exophthalmos improved dramatically in all patients within months after starting TCZ. Mean Clinical Activity Score decreased from 4.80 ±  1.13 to 0.70 ± 0.82 points at 6 months (mean change: −4.10 ± 1.52; p < .0001). Proptosis improved from 23.2 ± 2.1 to 20.6 ± 2.0 mm at 6 months (mean change: −2.9 ± 1.4 mm; p < .0001). Diplopia resolved in 7 patients. Thyroid receptor antibodies decreased markedly during TCZ treatment. Baseline serum IL‐6 levels did not predict clinical response. TCZ was well‐tolerated. During follow‐up, 3 patients were diagnosed with cancer (breast cancer in 2 and urothelial cancer in 1).ConclusionsTCZ was rapidly effective and well‐tolerated in our patients with GC‐refractory GO. Four patients experienced mild/moderate adverse events as neutropenia, hyperlipidemia, and infections; nearly a third developed cancer during the follow‐up. The increased incidence observed could be explained by the high prevalence of smokers, that are at higher risk for Graves' orbitopathy and solid malignancies as breast cancer. Thus, regular cancer screening could be proposed to this vulnerable population receiving high doses of immunosuppressants.
Agency in everyday life: An ethnography of the moral experiences of children and youth
Authors: Siedlikowski Sophia , Van Praagh Shauna , Shevell Meaghan , Carnevale Franco A. 
Published: December 2021

AbstractDrawing on a hermeneutic ethnographic methodology, we studied the everyday moral experiences of young people aged 11 to 16 and how these related to expressions of agency. Our results revealed that young people's agency was manifested through three interrelated dimensions: their aspirations, concerns, and capacities. Agential expression was context dependent, either bolstered or thwarted by certain people or social institutions. Our study empirically supports our ontological advancement of Childhood Ethics as a sub‐specialization of Childhood Studies, offering novel evidence on children's agency. This work further promotes the importance of meaningfully including young people in discussions, decisions, and actions that affect them.
The Historical Burdens and Management System Problems That Prevent Japanese Zoos from Concentrating on Conservation and Animal Welfare
Authors: Sadotomo Yoichi 
Published: December 2021

AbstractThis study investigated the management system problems of Japanese zoos by analyzing their history. Zoos are an imported form of Western culture, though they have led to improved animal husbandry techniques in Japan, which were extremely poor before their introduction. However, governments have treated zoos as financial sources for funding parks and museums. This changed around 1970, when Japanese zoos became dependent on tax revenues. Governments’ influences are often very strong, leaving zoo directors with insufficient authority over zoos’ personnel, admission fees, facility construction, and so on. In fact, Japanese zoos typically lack curator systems, and the facility construction authority is separate from zoos’ maintenance efforts. These are serious obstacles to the promotion of conservation and animal welfare, and no satisfactory system has been introduced to date. It is necessary to find a better long‐term management system for running Japanese zoos using a combination of tax revenues and donations.
Insights into déjà vu: Associations between the frequency of experience and amplitudes of low‐frequency oscillations in resting‐state functional magnetic resonance imaging
Authors: Zatloukalova Eva , Mikl Michal , Shaw Daniel Joel , Marecek Radek , Sakalosova Lenka , Kuratkova Marie , Mitterova Kristyna , Sklenarova Barbora , Brazdil Milan 
Published: December 2021

AbstractThe phenomenon of déjà vu (DV) has intrigued scientists for decades, yet its neurophysiological underpinnings remain elusive. Brain regions have been identified in which morphometry differs between healthy individuals according to the frequency of their DV experiences. This study built upon these findings by assessing if and how neural activity in these and other brain regions also differ with respect to DV experience. Resting‐state fMRI was performed on 68 healthy volunteers, 44 of whom reported DV experiences (DV group) and 24 who did not (NDV group). Using multivariate analyses, we then assessed the (fractional) amplitude of low‐frequency fluctuations (fALFF/ALFF), a metric that is believed to index brain tissue excitability, for five discrete frequency bands within sets of brain regions implicated in DV and those comprising the default mode network (DMN). Analyses revealed significantly lower values of fALFF/ALFF for specific frequency bands in the DV relative to the NDV group, particularly within mesiotemporal structures, bilateral putamina, right caudatum, bilateral superior frontal cortices, left lateral parietal cortex, dorsal and ventral medial prefrontal cortex, and the posterior cingulate cortex. The pattern of differences in fALFF/ALFF measures between the brains of individuals who have experienced DV and those who have not provides new neurophysiological insights into this phenomenon, including the potential role of the DMN. We suggest that the erroneous feeling of familiarity arises from a temporary disruption of cortico‐subcortical circuitry together with the upregulation of cortical excitability.
“What we have here is a failure to communicate”: The misuse of attachment and bonding in the courtroom: A call for definitions and explanations
Authors: Rappaport Sol R. 
Published: December 2021

AbstractAttachment and bond are two words often used in child custody evaluations and in family courts. Many professionals misuse these terms. Professionals often use phrases such as “strong attachment,” “healthy bond,” and “well‐attached,” all phrases which are not in the scientific literature. Attachment has a specific definition in the scientific literature. Furthermore, other than the Strange Situation method of assessment, there are no well‐research reliable and valid methods for assessing the type of attachment, as defined in the scientific literature. Until such measures exist, evaluators, therapists, and family court professionals should avoid using the term attachment to describe parent‐child relationships, and instead focus on functional aspects of the parent‐child relationship.
DELEUZE'S FOUCAULT: ON THE POSSIBILITY OF AN OUTSIDE OF KNOWLEDGE/POWER
Authors: PALTI ELÍAS J. 
Published: December 2021

ABSTRACTDuring 1985 and 1986, Gilles Deleuze directed a seminar on Michel Foucault's work at the University of Paris 8 at Vincennes/St. Denis. The course was divided into three parts, one dedicated to each of the three levels on which, according to Deleuze, Foucault's concept of thinking unfolds: knowledge, power, and subjectivation. As I will show, Deleuze's attempt to reconstruct Foucault's perspective on the history of thought is highly enlightening, although, at some crucial points, it raises doubts regarding the plausibility of the hypotheses that Deleuze attributed to Foucault. In particular, in the third part, which focuses on subjectivation, it is not clear whether Deleuze was attempting to relate Foucault's concept or to expose his own ideas on the topic. The displacements, which Deleuze introduced into Foucault's perspective, are particularly interesting, since they are symptomatic of broader epistemological problems that philosophical thought currently faces in attempting to articulate a consistent perspective of the possibility of an “outside” of power or, in Foucault's formulation, knowledge/power.
KOSELLECK ON “HISTORIES” VERSUS “HISTORY”; OR, HISTORICAL ONTOLOGY VERSUS HISTORICAL EPISTEMOLOGY
Authors: ANKERSMIT FRANK R. 
Published: December 2021

ABSTRACTThe theme of this journal issue deals with the opposition between what can be said to be the “inside” and the “outside” of a culture or a civilization, a question that can be approached in different ways. To begin with, one may ask whether certain anthropological constants can be discerned in all of humanity or, to take the opposite approach, whether civilizations possess certain cultural features that are unique to them. An approach focusing on certain anthropological constants gives us access to an “inside” shared by all of humanity, whereas the latter approach is part of how a civilization demarcates itself from its “outside.” How “inside” and “outside” relate to each other had best be investigated historically, since cultural and social differentiation grow historically out of the common soil of anthropological constants. This article focuses on Reinhart Koselleck's oeuvre to illustrate this claim. Why Koselleck? To begin with, one may find in his work an “inside” defined in terms of a philosophical anthropology and a culturally defined “outside,” both of which he contrasts in an original and thought‐provoking way. As I will argue, the contrast runs parallel to the one between historical ontology and historical epistemology that can be discerned in Koselleck's writings. I will show how the dichotomy between ontology and epistemology reappears in his notion of the saddle time (Sattelzeit)—that is, the period in which Western modern historical writing was born. Prior to the saddle time, history was seen as the product of the anthropological constants of human nature, but afterward, these constants had to give way to the belief in a historical development requiring a historical epistemology to achieve historical truth. This is how the “inside” (ontology) and the “outside” (epistemology) are interwoven in Koselleck's notion of the Sattelzeit. In sum, ontology provides an interculturally shared “inside,” whereas epistemology divides it into as many “insides” as there are different civilizations.
THRIVING ON THE MARGINS OF HISTORY: ENGAGING WITH THE PAST IN THE VERNACULAR
Authors: ASHAR MEERA 
Published: December 2021

ABSTRACTA diversity of discursive formations in the vernacular flourish on the margins of history, and even outside it. To better understand these formations, particularly in postcolonial societies such as India, I argue that it is important to eschew the sole use of the lens of veracity. I explore alternative lenses through which to more fruitfully examine historical narratives in the vernacular: the contrast between the “historical past” and the “practical past,” the complexities involved in cultural translation, and the lyrical and fictionalized nature of prior accounts of the past. I employ these alternative lenses to make sense of Gujarati author Nandśaṅkar Tuḷjāśaṅkar Mehtā's use of the historical novel form in his pioneering historical work, Karaṇ Ghelo, Gujarātno chello Rajpūt rājā: ek vārtā (Karaṇ the Crazy, Gujarat's Last Rajput King: A Story), the first novel written in Gujarati. Writing at a time when the demand for histories and history textbooks was burgeoning, Mehtā made the curious choice to write a vārtā, or “story”—a choice that becomes more comprehensible when seen from the alternative perspectives I propose.
THE HORIZON OF HISTORY MOVED BY MODERNITY: AFTER AND BEYOND KOSELLECK
Authors: RÜSEN JÖRN 
Published: December 2021

ABSTRACTThis article first describes Reinhart Koselleck's interpretation of the modernity of historical thought and then discusses the specific meaning‐orientation of this thought. This description is done in a perspective that follows the question of whether modernity is only an epoch in Western history or covers general, universal history. Then, it discusses three problem areas of this conception of modernity: (1) whether there is an alternative to Koselleck's model, (2) whether this model applies only to Western historical thought, and (3) what problems it raises. Afterward, it offers suggestions for how Koselleck's list of “counter‐concepts” can be expanded to include further provisions. Finally, it identifies and discusses the criteria of meaning that are decisive for the expanded conception of basic historical‐anthropological concepts.