bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aurora Kinase A as a Diagnostic and Prognostic Marker of Malignant Mesothelioma
Authors: Guo Zhenying , Shen Li , Li Ningning , Wu Xiaoxiao , Wang Canming , Gu Zheng , Chen Zhongjian , Liu Junping , Mao Weimin , Han Yuchen 
Published: December 2021

BackgroundMalignant mesothelioma (MM) is a highly aggressive cancer with a poor prognosis. Despite the use of several well-known markers, the diagnosis of MM is still challenging in some cases. we applied bioinformatics to identify key genes and screen for diagnostic and prognostic markers of MM.MethodsThe expression profiles of GSE2549 and GSE112154 microarray datasets from the Gene Expression Omnibus database contained 87 cases of MM tissue and 8 cases of normal mesothelial tissue in total. The GEO2R tool was used to detect differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of DEGs were performed using DAVID Bioinformatics Resources. The DEGs protein-protein interaction networks were constructed from the STRING database. Cytoscape was used to identify significant modules and hub genes. The GEPIA database was used to explore relationships between hub genes and prognosis of MM. Immunohistochemistry was used to analyze protein expression in tissue microarrays with 47 Chinese MM tissues. Statistical analyses diagnostic and prognostic values.Results346 DEGs were identified: 111 genes upregulated, and 235 downregulated. GO analysis showed that the primary biological processes of these DEGs were cell adhesion, leukocyte migration, and angiogenesis. The main cellular components included the extracellular space, extracellular exosome, and extracellular region. The molecular functions were integrin binding, heparin binding, and calcium ion binding. KEGG pathway analysis showed that DEGs are primarily involved in PPAR signaling pathway, extracellular matrix–receptor interactions, and regulation of lipolysis in adipocytes. Survival analysis showed that seven genes—AURKA, GAPDH, TOP2A, PPARG, SCD, FABP4, and CEBPA—may be potential prognostic markers for MM. Immunohistochemical studies showed that Aurora kinase A (AURKA gene encode, Aurora-A) and GAPDH were highly expressed in MM tissue in comparison with normal mesothelial tissue. Kaplan-Meier analysis confirmed a correlation between Aurora-A protein expression and overall survival but did not confirm a correlation with GAPDH. The receiver operating characteristic curves of Aurora-A protein expression suggested acceptable accuracy (AUC = 0.827; 95% CI [0.6686 to 0.9535]; p = 0.04). The sensitivity and specificity of Aurora-A were 83.33% and 77.78%, respectively.ConclusionAurora-A could be an optimal diagnostic biomarker and a potential prognostic marker for MM.
Causes of Melena and Effective Examination Strategies in Children
Authors: Iwama Itaru , Yoshida Masashi , Hara Tomoko , Nambu Ryusuke 
Published: December 2021

Background and Aim: Melena, or tarry black stool, is not a rare symptom encountered in pediatric clinical practice, and the bleeding source varies from the upper gastrointestinal tract to the small intestine. Endoscopy is effective in identifying bleeding, but it does not always identify the source of bleeding. Endoscopic examination in children is commonly challenging, and there are no detailed reports about the causes of melena in children. This observational study aimed to validate the cause of melena in children and to investigate more effective and less burdensome examination methods.Methods: We retrospectively reviewed the clinical records of 55 patients who underwent examination for melena.Results: In this research, 38 patients had underlying diseases such as malignancy and severe mental and physical disorders. The bleeding source was identified in 39 patients. The most common final diagnosis was duodenal ulcer (n = 22), and the other diagnoses were gastric ulcer, esophagitis, and esophageal varices. The upper gastrointestinal tract was the most common source of bleeding (n = 34). In five patients, the bleeding source was the small intestine. Vomiting, abnormal abdominal ultrasonography findings, and a hemoglobin level of ≤ 3 g/dL than the lower normal limit were significant factors indicating that the bleeding source can be found on esophagogastroduodenoscopy.Conclusions: The upper gastrointestinal tract was the most common bleeding source of melena in children. As in adults, esophagogastroduodenoscopy is the primary endoscopic method of choice. Furthermore, small bowel capsule endoscopy may be useful in identifying the bleeding source in children without upper gastrointestinal lesions.
Cajanol Sensitizes A2780/Taxol Cells to Paclitaxel by Inhibiting the PI3K/Akt/NF-κB Signaling Pathway
Authors: Sui Ming , Yang Hairong , Guo Mingqi , Li Wenle , Gong Zheng , Jiang Jing , Li Peiling 
Published: December 2021

Ovarian cancer is the second most common gynecological malignancy, and one of the most deadly. The bottleneck restricting the treatment of ovarian cancer is its multi-drug resistance to chemotherapy. Cajanol is an isoflavone from pigeon pea (Cajanus cajan) that has been reported to have anti-tumor activity. In this work, we evaluate the effect of cajanol in reversing paclitaxel resistance of the A2780/Taxol ovarian cancer cell line in vitro and in vivo, and we discuss its mechanism of action. We found that 8 μM cajanol significantly restored the sensitivity of A2780/Taxol cells to paclitaxel, and in vivo experiments demonstrated that the combination of 0.5 mM/kg paclitaxel and 2 mM/kg cajanol significantly inhibited the growth of A2780/Taxol metastatic tumors in mice. Flow cytometry, fluorescence quantitative PCR, western blotting and immunohistochemical staining methods were used to study the mechanism of reversing paclitaxel resistance with cajanol. First, we determined that cajanol inhibits paclitaxel efflux in A2780/Taxol cells by down-regulating permeability glycoprotein (P-gp) expression, and further found that cajanol can inhibit P-gp transcription and translation through the PI3K/Akt/NF-κB pathway. The results of this work are expected to provide a new candidate compound for the development of paclitaxel sensitizers.
Families and Collective Futures: Developing a Program Logic Model for Arts-Based Psychosocial Practice With South African Rural Communities
Authors: Havsteen-Franklin Dominik , Swanepoel Marlize , Jones Jesika , Conradie Uné 
Published: December 2021

Aim: This aim of this study is to describe the development of a program logic model to guide arts-based psychosocial practice delivered in rural South African farming communities affected by transgenerational traumas.Background: The rationale for developing a program logic model for arts-based psychosocial practice in South Africa was based on the lack of evidence for effective community arts-based psychosocial interventions for collective trauma, unknown consensus about best practices and the need for developing cogent collective psychosocial practices. Further to this, the aims and benefits of the practice required clarity given the psychosocial complexity of the environment within which the practices for this population are being offered. The logic model offers a valuable resource for practitioners, participants and funders to understand the problem being addressed, how practice is defined, as well as the impact of practice and on intermediate and longer term goals.Methods: The authors used a systematic iterative approach to describe the operationalization of arts-based psychosocial practice. This resulted in the design of the logic model being informed by data from focus groups, an overview of the literature regarding transgerenational trauma in this population, operational policies and organizational documents. The development of the logic model involved actively investigating with practitioners their work with remote farming communities. We thematised practitioners practice constructs to identify salient practice elements and their relationship to perceived benefits and lastly feedback from practitioners and participants following implementation to make adjustments to the logic model.Results: The results were clearly identified in the form of visual mapping using the design of a program logic model. The logic model was divided into 5 parts and was verified by practitioners following implementation. The parts of the program logic model are (Part 1) main presenting problem, (Part 2) operational processes, (Part 3) practice elements, (Part 4) benefits, and impact and (Part 5) review.
Quality of Life Is Not Deteriorated After Extrapleural Pneumonectomy vs. (Extended) Pleurectomy/Decortication in Patients With Malignant Pleural Mesothelioma
Authors: Lauk Olivia , Patella Miriam , Neuer Thomas , Inci Ilhan , Weder Walter , Opitz Isabelle 
Published: December 2021

Background: Extrapleural pneumonectomy (EPP) for malignant pleural mesothelioma (MPM) is highly abandoned due to high morbidity and mortality rates and impaired quality of life (QoL). However, there are still rare indications for this intervention. The aim of this longitudinal prospective study was to monitor QoL and lung function in patients undergoing EPP and compare the outcomes with extended pleurectomy/decortication [(E)PD].Methods: Between June 2013 and June 2017, 42 patients underwent induction chemotherapy followed by either EPP (n = 7) or (E)PD (n = 35). All patients filled out the EORTC QLC-C15-PAL, –LC13, and SF-36 self-rating questionnaires pre-operatively, 6 weeks and 4 months after the operation. Additionally, lung function was measured pre-operatively and 4 months post-operatively.Results: We observed no significant differences in all QoL categories (general global health, pain, and dyspnea) between both surgical procedures, over the whole observation period. Moreover, a general tendency toward restoration of the pre-operative QoL status was documented at 4 months after the both operations. Forced expiratory volume in 1 s (FEV1) showed a significant decrease after surgery in both the groups [EPP group p = 0.06 and (E)PD group p &lt; 0.001]; also, the forced volume vital capacity (FVC) significantly decreased (EPP group p = 0.046 P/D group &lt;0.001). Diffusion capacity did not show significant changes.Conclusion: According to these results, QoL is no longer severely impaired after EPP compared with EPD, and therefore should not be used as an argument against EPP in principle. However, indication has to be carefully evaluated for each patient.
Análisis el comportamiento del consumidor de Almacenes Jácome de la Ciudad de Riobamba, Ecuador
Authors: Veintimilla Soliz Deysi Janneth , Guerra Flores Cristian Oswaldo , Vasco Vasco Jorge Antonio 
Published: December 2021

El presente trabajo de investigación influyen en el comportamiento del consumidor de Almacenes Jácome de la ciudad de Riobamba, tiene como objetivo determinar qué factores ayudan a mejorar la toma de decisiones de compra de productos electrodomésticos. Para lo cual se aplicó una investigación cualitativa – cuantitativa, empleando técnicas como la observación, la encuesta basada en el modelo predeterminado de comportamiento del consumidor de Howard y Sheth y finalmente se utilizó el equipo biométrico eyetraking que permitió analizar imágenes publicitarias. Luego de ser analizados e interpretados los datos, se evidencio que los factores de decisión más relevantes son: calidad, durabilidad, precios convenientes, marca, servicio al cliente, y tiempo de entrega del producto. Además, demostró la necesidad de mejorar el medio de información que en preferencia son las redes sociales, en cuanto a la experimentación se logró identificar que las imágenes no poseen elementos que llamen la atención de los consumidores.

Palabras clave: consumidor; marketing; decisión; compra; modelo de Howard y Sheth.
Rediseño organizacional basado en el enfoque por procesos en una empresa del sector del tabaco
Authors: Rúa Alexei , García Osie , Ruiz Sebastiana , Alfonso Daniel 
Published: December 2021

La investigación que se presenta tiene como objetivo general estudiar el rediseño organizacional basado en el enfoque por procesos en una empresa del sector del tabaco. En el cumplimiento del objetivo se demuestran las limitaciones entre los procesos que intervienen en la cadena de suministro de una empresa productora y comercializadora de ese producto. Para la investigación se tomó el procedimiento de rediseño organizacional, aplicándose las seis (6) fases que propone el mismo y parte del Modelo General de la Organización, específicamente en análisis del flujo informativo de la empresa. El nivel de integración de los procesos que intervienen en la cadena de suministro de la empresa fue de 0,43 siendo este resultado valorado de bajo.

Palabras clave: diseño organizacional; modelo general de la organización; cadena de suministro

ABSTRACT
In the research that is presented, the limitations between the processes that intervene in the supply chain of a production and marketing company in the tobacco sector are demonstrated. For the investigation, the Organizational Redesign Procedure was taken, applying the six (6) phases proposed by the same and part of the General Model of the Organization, specifically in the analysis of the company’s information flow. The level of integration of the processes involved in the company’s supply chain it was 0.43, this result being valued as low.

Keywords: organizational design; general model of the organization; supply chain
Presupuesto participativo en gobiernos autónomos descentralizados municipales de la provincia Santo Domingo de los Tsáchilas - Ecuador
Authors: Pilay Toala Félix Sixto , Ugando Peñate Mikel 
Published: December 2021

Es importante la gestión presupuestaria para superar la debilidad y deficiencia en la implementación del presupuesto participativo en los gobiernos municipales de la provincia de Santo Domingo de los Tsáchilas; el objetivo busca que las entidades tengan una herramienta para elaborar el presupuesto y cumplan con el marco legal. Pese a las leyes, se observa debilidad en la gestión que provoca que los recursos asignados por el gobierno central y los recaudados no lleguen a los sectores vulnerables. La investigación se desarrolló en los cantones Santo Domingo y La Concordia, Se abordó, el enfoque mixto, se realizaron 656 encuestas con cuestionario estructurado y semiestructurado a personas mayores de edad, entrevistas a las autoridades, equipo técnico y a líderes de opinión. Los resultados evidenciaron el deficiente acceso a las necesidades prioritarias, debilidad de gestión, se concluye, que los recursos propios y las asignaciones no son distribuidos de manera participativa, equitativa y solidaria.

Palabras clave: participación social, política, derechos, economía, gestión

ABSTRACT
Budget management is important to overcome the weakness and deficiency in the implementation of the participatory budget in the municipal governments of the province of Santo Domingo de los Tsáchilas; The objective is for entities to have a tool to prepare the budget and comply with the legal framework. Despite the laws, there is a weakness in the management that causes that the resources assigned by the central government and those collected do not reach the vulnerable sectors. The research was developed in the cantons of Santo Domingo and La Concordia, the mixed approach was addressed, 656 surveys were carried out with a structured and semi-structured questionnaire to people of legal age, interviews with authorities, technical team and opinion leaders. The results evidenced poor access to priority needs, management weakness, it is concluded that own resources and allocations are not distributed in a participatory, equitable and supportive manner.

Keywords: social participation, politics, rights, economy, management
Programas de servicios sociales para erradicar la pobreza en el Ecuador
Authors: Moreira Macías María Fernanda , Barreno Salinas Maria Mercedes 
Published: December 2021

Este trabajo investigativo tiene como finalidad analizar los programas de servicios sociales para erradicar la pobreza en el Ecuador, para lo cual se plantan las siguientes interrogantes: ¿Cuántos son los programas sociales implementados en el Ecuador y cuáles de estos han tenido un mayor impacto en la erradicación de la pobreza? A fin de responder estas preguntas hemos utilizado información primaria y secundaria a través del Ministerio de Inclusión Económica y Social y del Instituto Nacional de Estadística y Censo para abordar las bases de datos del año 2007 al 2017, así como también información proporcionada por la CEPAL. Los resultados indican que la pobreza en el Ecuador ha disminuido. Se concluye que para seguir reduciendo los niveles de pobrezas se requiere un mayor control por parte del Estado y la participación activa del sector privado para la canalización de los programas de servicios sociales.

Palabras clave: Pobreza; erradicar; programas; servicios sociales; medición.

ABSTRACT

The purpose of this research work is to analyze the social services programs to eradicate poverty in Ecuador, for which the following questions are planted: How many social programs are implemented in Ecuador and which of these have had a greater impact on the eradication of poverty? In order to answer these questions, we have used primary and secondary information through the Ministry of Economic and Social Inclusion and the National Institute of Statistics and Census to address the databases from 2007 to 2017, as well as information provided by CEPAL. The results indicate that poverty in Ecuador has decreased. It is concluded that in order to continue reducing poverty levels, greater control by the State and the active participation of the private sector are required to channel social services programs.

Keywords: Poverty; eradicate; programs; social services; measurement
Análisis del impacto del régimen impositivo simplificado ecuatoriano. Período 2014 al 2018
Authors: Pesantez Cedeño Zoila Filomena , Sagñay Sagñay Luis Vinicio 
Published: December 2021

El sector público necesita disponer de recursos para llevar a cabo sus actividades y el tributo es una vía importante en la obtención de esos recursos. El llamado para la recaudación y control de contribuyentes a fin de una distribución más equitativa de la riqueza, explica la pertinencia del estudio cuyo objetivo es analizar el impacto del Régimen Impositivo Simplificado Ecuatoriano (RISE) en la economía ecuatoriana en los años 2014 al 2018; período de transformaciones en el sistema tributario de Ecuador. La contrastación del RISE frente a otros tributos, inicia la investigación apoyada en una metodología descriptiva, con carácter documental y bibliográfico desde un enfoque mixto. El RISE se implementa como alternativa para aliviar el nivel de evasión fiscal, por los beneficios de una práctica sin complejidades para microempresas y las pequeñas y medianas empresas (PYMEs), caracterizadas por baja capacidad económica y nivel de ingresos, siendo necesario fomentar la cultura tributaria.

Palabras clave: Finanzas, política fiscal, tributación, ingreso, cultura tributaria.

ABSTRACT

The public sector needs resources to carry out its activities and the tax is an important path in obtaining these resources. The call for the collection and control of taxpayers for a more equitable distribution of wealth explains the relevance of the study aimed at analysing the impact of the Simplified Tax Regime (RISE) on the Ecuadorian economy in the years 2014 to 2018; period of transformations in Ecuador’s tax system. The contrasting of RISE against other tributes initiates’ research based on a descriptive methodology, on a documentary and bibliographic basis from a mixed approach. RISE is implemented as an alternative to alleviate the level of tax evasion, for the benefits of a non-complexity practice for micro and small and medium-sized enterprises (SMEs), characterized by low economic capacity and income level, and it is necessary to promote tax culture.

Keywords: Finance, fiscal policy, taxation, income, tax culture.
Uso de normas de calidad: estudio comparado de empresas atuneras en la ciudad de Manta-Ecuador (2018-2019)
Authors: Huaygua Apaza Maribel , Cedeño Menéndez Yira Tatiana , Coral Byron Vicente 
Published: December 2021

La ciudad de Manta se destaca por su contribución económica en la manufactura de atún destinada principalmente a los mercados internacionales. Las empresas atuneras de Manta utilizan en sus procesos productivos las normas de la Organización Internacional para la Estandarización ISO-9001 (2008). En los próximos años estas empresas deberán actualizar la ISO 9001 (2015) que engloba nuevos parámetros e indicadores. El presente estudio hace énfasis en el análisis de los resultados obtenidos a partir de la aplicación de la versión ISO 9001 (2008) en una muestra de cinco empresas atuneras de la ciudad de Manta, a fin de realizar un análisis comparativo utilizando los criterios de evaluación de los premios de calidad Edwards Deming. El objetivo de este estudio es conocer los resultados de aplicar normas de calidad en el comercio del atún. El estudio refleja que el uso de normas de calidad es una condición necesaria pero no suficiente.

Palabras clave: Comercio, medio ambiente, consumidor, industrialización, cultura corporativa.

ABSTRACT
The city of Manta stands out for its economic contribution to the manufacture of tuna mainly destined for international markets. The Manta tuna companies use the standards of the International Organization for Standardization ISO-9001 (2008) in their production processes. In the coming years, these companies will have to update ISO 9001 (2015), which includes new parameters and indicators. This study emphasizes the analysis of the results obtained from the application of the ISO 9001 (2008) version in a sample of five tuna companies in the city of Manta, to carry out a comparative analysis using the evaluation criteria of the Edwards Deming quality awards, the objective of this study is to know the results of applying quality standards in the tuna trade. The study reflects that the use of quality standards is a necessary but not sufficient condition.

Keywords: Trade, environment, consumer, industrialization, corporate culture.