bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insight of oral vaccines as an alternative approach to health and disease management: An innovative intuition and challenges
Authors: Debnath Nabendu , Thakur Mony , Khushboo  , Negi Neelam P. , Gautam Vibhav , Kumar Yadav Ashok , Kumar Deepak 
Published: November 2021

AbstractVaccination is the most suitable and persuasive healthcare program for the prohibition of various deadly diseases. However, the higher production cost and purification strategies are out of reach for the developing nations. In this scenario, development of edible vaccine turns out to be the most promising alternative for remodeling the pharmaceutical industry with reduced production and purification costs. Generally, oral route of vaccination is mostly preferred due to its safety, compliance, low manufacturing cost and most importantly the ability to induce immunity in both systemic and mucosal sites. Genetically modified microorganisms and plants could efficiently be used as vehicles for edible vaccines. Edible vaccines are supposed to reduce the risk associated with traditional vaccines. Currently, oral vaccines are available in the market for several viral and bacterial diseases like cholera, hepatitis B, malaria, rabies etc. Herein, the review focuses on the breakthrough events in the area of edible vaccines associated with dietary microbes and plants for better control over diseases.
Relationship between PPAR‐γ gene polymorphisms and ischemic stroke risk: A meta‐analysis
Authors: Cheng Fan , Si Xiao‐Min , Yang Gong‐Li , Zhou Lan 
Published: November 2021

AbstractBackgroundPublished researches have suggested some associations between PPAR‐γ and ischemic stroke (IS) development. This meta‐analysis was conducted to evaluate the association between PPAR‐γ gene polymorphisms and IS risk.Materials and methodsA systematic search was conducted in PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases. The pooled association of odd ratios (ORs) and its 95% confidence interval (CI) was calculated to assess the IS risk of PPAR‐γ rs1801282 C/G and rs3856806 C/T polymorphisms. Furthermore, the heterogeneity test, cumulative analyses, sensitivity analyses, and publication bias were conducted.ResultSixteen publications with 3786 cases and 5343 controls were identified. Overall findings indicated that rs1801282 C/G polymorphism may be associated with an increased risk for IS (GG vs. CC: OR = 2.17 95%CI = 1.09–4.35, p = .03, I2 = 0%; GG vs. CC+CG: OR = 2.15, 95%CI = 1.07–4.32, p = .03, I2 = 0%). The similar results were also found in the subgroup analysis. In addition, no significant association was observed between rs3856806 C/T polymorphism and IS risk.ConclusionIn conclusion, our study showed that PPAR‐γ rs1801282 C/G polymorphism probably plays an important role in IS occurrence. The result should be verified with more studies in the future.
Development of di(2‐ethylhexyl) phthalate‐containing thioglycolic acid immobilized chitosan mucoadhesive gel as an alternative hormone therapy for menopausal syndrome
Authors: Yang I‐Hsuan , Lin I‐En , Liang Ya‐Jyun , Lin Jhih‐Ni , Chen Tzu‐Chien , Chen Zhi‐Yu , Kuan Che‐Yung , Chi Chih‐Ying , Li Chi‐Han , Wu Hung‐Ming , Lin Feng‐Huei 
Published: November 2021

AbstractMenopausal syndrome includes the symptoms that most women experience owing to hormone changes after menopause. Although hormone replacement therapy is a common treatment for menopausal syndrome, there are still many side effects and challenges hindering research. In this study, thioglycolic acid (TGA)‐immobilized chitosan mucoadhesive gel was synthesized by a new method of low concentration of 1,4‐butanediol diglycidyl ether (BDDE) would encapsulate di(2‐ethylhexyl) phthalate (DEHP) as an alternative hormone replacement therapy for menopausal syndrome. The efficacies of the DEHP‐containing TGA‐chitosan gel (CT‐D) were confirmed and evaluated by materials characterization and in vitro study. Results showed that CT‐D was not cytotoxic and had better mucoadhesive ability than chitosan. The animal model was constructed 1 month after bilateral ovariectomy in SD rats. CT‐D was administered intravaginally every 3 days. Bodyweight, wet weight of the uterus and vagina, vaginal smears, histology, blood element analysis, and serological analysis was used to assess the ability of the material to relieve menopausal syndrome. The results indicated that the combination of the sustained release of DEHP and mucoadhesive TGA‐immobilized chitosan allows the developed CT‐D to relieve the menopausal syndrome through low concentrations of DEHP, which falls in the safety level of the tolerable daily intake of DEHP.
Volatile Composition Variability of Arnica montana Wild Populations of Trentino‐Alto Adige, Italy, Determined by Headspace‐Solid Phase Microextraction
Authors: Fusani Pietro , Aiello Nicola , Shachter Alona , Dudai Nativ 
Published: November 2021

AbstractArnica montana is a plant distributed in most of Europe, including the Alpine arc and Apennines in Italy, and traditionally used worldwide for medicinal properties. Twelve natural populations of the species from Trentino‐Alto Adige, Italy, were characterized using Headspace‐Solid Phase Microextraction analysis for their volatile profile. Fifty‐one compounds were detected in flower heads, the most abundant being (E)‐Caryophyllene (23.4 %), 2,2,4,6,6‐Pentamethylheptane (8.3 %), α‐ trans‐Bergamotene (7.2 %), Germacrene D (5.7 %), and Hexanal (5.3 %). A multivariate analysis performed on the ten most abundant compounds grouped these investigated accessions into five main clusters. Three clusters, comprising together five accessions, were linked to the geographical origin of two collection sites. This work is a complete characterization of volatiles of the species by SPME analysis reported to date. Furthermore, results suggest that the species’ volatile profile can be linked to the geographical origin of the natural populations and, therefore, represent a tool for evaluating biodiversity within the species.
The relevance of post‐traumatic stress disorder as a moderator of the relationship between experience of violent or sexual assault and opioid use in adulthood
Authors: Wojciechowski Thomas 
Published: November 2021

AbstractBackgroundPast research has indicated that individuals suffering from post‐traumatic stress disorder (PTSD) may demonstrate increased sensitivity to stress exposure following onset of the disorder. Thus, having PTSD may amplify the effects of subsequent stressors. This has been found to be relevant in some forms of substance use but relationships between PTSD, new stress and opioid use specifically has not been examined.AimsTo explore interactions between PTSD, new victimisation and opioid use and test the hypothesis that PTSD will moderate any victimisation–opioid use relationship.MethodsThe pathways to desistance data were used in analyses. A series of logistic regression models were used to test both direct effects of victimisation and PTSD on opioid use and interactions between them.ResultsThe sample was comprised of a male majority (male N = 1,170; female N = 184). Results indicated that neither PTSD nor victimisation were significant predictors of opioid use. PTSD was found to moderate the relationship between victimisation and opioid use in the hypothesised manner.ConclusionsThere may be clinical implications of these results relating to both inpatient and outpatient treatment. Regular trauma screening, additional victims' services and trauma‐informed care may help to reduce the risk of opioid use among individuals suffering from PTSD.
Effects of genotype and storage on physicochemical and functional properties of soybean protein isolates
Authors: Lindemann Igor da Silva , Lang Gustavo Heinrich , Batista Cristian de Souza , El Halal Shanise Lisie Mello , Santos Jaqueline Pozzada dos , Vanier Nathan Levien 
Published: November 2021

AbstractBackground and ObjectivesSoy protein isolates (SPIs) play important roles in many food products because they exhibit good nutritional value and positive effects on food texture. In this study, SPIs of 12‐month stored and non‐stored soybeans, from six genotypes (NS 5959, NS 5909, NS 6535, 95R95IPRO, 96Y90, and CZ26B42), were investigated. The extraction yield, purity, sodium dodecyl sulfate–polyacrylamide gel electrophoresis, Fourier transform infrared spectroscopy, relative fluorescence intensity, water and oil holding capacities, emulsion stability, solubility at different pH, and foaming properties were evaluated.FindingsStorage reduced the extraction yield in all genotypes and increased the protein surface hydrophobicity of the 95R95IPRO genotype. The NS 5959 SPI presented higher water and oil absorption capacities. The emulsions of the NS 5909 SPI presented greater phase separation, mainly on the 7th and 9th days, compared with those of the other genotypes.ConclusionThe functional characteristics of SPI depend on soybean genotype and storage. Like this, industries must be aware of segregating lots by their traits in order to obtain SPI with unique characteristics for certain applications.Significance and NoveltyThis study demonstrated detailed structural, molecular, and functional properties of SPI from soybean genotypes produced in Brazil. Results may be useful to industries and soybean researchers in order to develop soybean and SPI products with specific characteristics.
Eslicarbazepine‐induced severe hyponatremia resulted in generalized tonic‐clonic seizure
Authors: Habib Mhd Baraa , Elshafei Mohammad , Ali Elrazi , Sardar Sundus , Ali Khaled , Haddad Naim , Abdelaty Mohamed 
Published: November 2021

AbstractAlthough eslicarbazepine is an anti‐seizure medication, it may result in seizure worsening if its use is complicated by severe hyponatremia, even long time after commencing this medication. The treatment is a replacement for another ASM.
A case of papillary hyperplasia of thyroid misdiagnosed as papillary thyroid carcinoma: Case report and review of literature
Authors: Alharbi Sara Faisal , Abba Arwa Ahmed , Hafiz Amal Abdulghaffar , Abdulhalim Aroob Mohammedamin , Bokhari Gadir Yaqoub , Esheba Ghada Elsayed 
Published: November 2021

AbstractOverdiagnosis of papillary thyroid hyperplasia which may mimic papillary thyroid carcinoma in fine‐needle aspiration and frozen section has a serious impact on the patient. Therefore, it is important to know the difference between them to avoid over or undertreatment.
Gallstone ileus: A rare cause of small intestine obstruction
Authors: Mulita Francesk , Tchabashvili Levan , Bousis Dimitrios , Kehagias Dimitrios , Kaplanis Charalampos , Liolis Elias , Perdikaris Ioannis , Iliopoulos Fotios , Verras Georgios‐Ioannis , Bouchagier Konstantinos 
Published: November 2021

AbstractGallstone ileus is a very rare cause of mechanical bowel obstruction with often‐delayed presentation and nonspecific symptoms. Aerobilia is found in approximately 50% of patients with gallstone ileus.
Response to pazopanib‐based combination regimen in a case of FGFR3 amplified gastric adenocarcinoma
Authors: Limaye Sewanti , Patil Darshana , Akolkar Dadasaheb , Srivastava Navin , Patil Revati , Apurwa Sachin , Patil Sanket , John Jinumary , Gosavi Rahul , Nesargikar Prabhu , Kumar Prashant , Datta Vineet , Bose Chirantan , Raazi Zarrine , Srinivasan Ajay , Datar Rajan 
Published: November 2021

AbstractAngiogenesis inhibitors (AGI) are not presently used for the treatment of gastric cancers. This report demonstrates that angiogenesis inhibitor can be safely and effectively used in combination with cytotoxic anti‐cancer agents for treatment of Gastric cancers.
Spontaneously shrinking lung mass due to Mycobacterium avium mimicking lung cancer
Authors: Kinjo Takeshi , Uechi Kohei , Kami Wakaki , Fujita Jiro 
Published: November 2021

AbstractNTM‐SPN is often indistinguishable from malignancy. Although surgical resection is sometimes chosen for the diagnosis and treatment, the mass in this case shrank spontaneously. Careful observation is required to avoid unnecessary interventions.
Paraquat‐induced acute kidney and liver injury: Case report of a survivor from Bangladesh
Authors: Asaduzzaman Md , Chando Monotush Ronjon , Ahmed Nasad , Rezwanul Islam Khandaker Mohammad , Alam Munsi Mohammad Jahangir , Roy Soumitra 
Published: November 2021

AbstractDespite high fatality following paraquat ingestion, a few percentages of patients survive even after organ damage appears. We need to focus more on careful clinical and laboratory monitoring. Early diagnosis and Supportive therapy are crucial.
Lung metastasis from renal cell carcinoma 16 years after nephrectomy: A case report and review of the literature
Authors: Singh Moushami , Aryal Vinayak , Dangol Ashis Man Singh , Neupane Karun , Gurung Banita , Shrestha Suniti , Tuladhar Sampurna Man , Maskey Swechha , Dhakal Hari Prasad 
Published: November 2021

AbstractRenal cell carcinoma can have lung metastasis even after a long interval of radical nephrectomy (16 years after nephrectomy in our case). If any pulmonary nodule is diagnosed with a history of RCC, pulmonary metastasis of RCC should be suspected and should be appropriately treated.
Multilevel percutaneous vertebroplasty with the Spine Jack® system in a patient with Cushing disease
Authors: Gil‐Ortiz Cuauhtemoc , Ramírez‐Romero Alberto , Bonifacio‐Delgadillo Dulce , Lagos‐Servellon Javier 
Published: November 2021

AbstractBackgroundPercutaneous vertebroplasty (PV) is a minimally invasive procedure that requires the injection of cement into a fractured vertebral body. Spine Jack® is a vertebroplasty system with an intracorporal implant designed to restore the height of the vertebral body in osteoporotic vertebral fractures. There are no reported cases of PV with Spine Jack® system as treatment for multilevel compression fractures in patients with vertebral osteoporosis due to Cushing disease.Case presentationA 55‐year‐old man with lumbago, impaired deambulation 6 weeks prior to presentation, with Oswestry score of 72% and a visual analogue scale (VAS) score of 9 points. Imaging studies showed osteoporotic fractures at T5, T8, T11, T12, and L1‐L5 vertebrae secondary to Cushing disease. PV was performed with a Spine Jack® intracorporal implant device, in three sessions, and multiple levels were operated at each intervention. Post‐operative course demonstrated improvement of pain, height, correction of the kyphotic angle and Oswestry score, without any neurological deficits despite having nine vertebral fractures.ConclusionPercutaneous vertebroplasty with the Spine Jack® system is a safe and effective procedure to treat multilevel vertebral fractures due to Cushing disease, improving the quality of life and allowing the patient to remain pain‐free while avoiding major surgery.
Rapid response to mycophenolate mofetil in combination with romiplostim in a case of severe refractory immune thrombocytopenia post COVID‐19 vaccination
Authors: Nutalapati Snigdha , Gupta Garima , Hildebrandt Gerhard C. 
Published: November 2021

AbstractVaccine mediated immune mediated thrombocytopenia (ITP) is exceedingly rare. We present a case of a young female who developed severe refractory ITP with multiple bleeding sites post second dose of COVID‐19 vaccination. She was treated with a combination of romiplostim and mycophenolate mofetil that resulted in rapid platelet count recovery.
Wandering spleen with splenic arteriovenous torsion
Authors: Hashiguchi Genichi , Hamada Takashi , Yamashita Mampei , Kuroki Tamotsu 
Published: November 2021

AbstractSplenic arteriovenous torsion causes splenomegaly and ischemic necrosis of the spleen. The recommended treatment for wandering spleen with hypersplenism is considered to be splenectomy.
Knowledge of cytogenetic analysis for synovial sarcoma in sarcomatoid variant renal cell carcinoma
Authors: Raza Vishal Farid , Arshad Dawood , Irshad Khalid , Khan Khalid Javeed 
Published: November 2021

AbstractSarcomatoid change in a renal tumor should undergo cytogenetic analysis of t(x;18) to prevent a missed diagnosis of synovial sarcoma. Surgeons should be vigilant regarding pathological correlation.
Joint Method for the Experimental and Computational Characterization of Ammonia Absorption Columns
Authors: Allenbrand Corban 
Published: November 2021

AbstractWell‐designed absorption columns are indispensable to industry. A prototypical system is the absorption of gaseous NH3. This experiment employed the method of transfer units where collection of vapor (V) and liquid (L) flow rates and concentrations enabled the characterization of the number of transfer units (NTU), height of transfer unit (HTU), and overall gas phase mass transfer coefficient (Ky). A nonmonotonic relationship between V, L, NTU, and HTU values was found; Ky showed a monotonic relationship with V and L. Computer‐simulated, correlation‐based, and experimental NTU, HTU, and Ky values demonstrated close numerical similarities. This experiment highlighted the importance of a combined empirical, theoretical, and simulation approach in achieving more reliable results from absorption column analysis.
Digital entrepreneurship: Some features of new social interactions
Authors: Braune Eric , Dana Leo‐Paul 
Published: November 2021

AbstractDigital technologies permit a massive reduction of transaction costs. As a result, traditional social interactions that take place in the entrepreneurial ecosystem are disrupted and a new landscape emerges. Digital platforms are the organizational form that benefit most from reductions in transaction costs; they take a prominent advantage from their ability to scout worldwide emergent knowledge, as well their ability to match extraordinarily heterogenous demands with dedicated supply. Digital platforms shape social interactions and the ways value is created in the global economy. As such, they are becoming the cornerstone of the digital entrepreneurship ecosystem. This special issue highlights some of the key features of the renewal of social interactions in the digital entrepreneurship ecosystem and opens up avenues for future research.
The utility of high‐risk human papillomavirus in situ hybridization in cytology cell block material from cystic head and neck lesions
Authors: Han Lucy M. , Saunders Tara A. , Calkins Sarah M. 
Published: November 2021

BackgroundHuman papillomavirus–related oropharyngeal squamous cell carcinoma (HPV‐OPSCC) presents frequently as metastasis in a neck lymph node that may be cystic or necrotic. Fine‐needle aspiration (FNA) biopsies are often first‐line diagnostic procedures. p16 immunohistochemistry (IHC) is a surrogate marker for high‐risk HPV (hrHPV) infection but can be challenging to interpret. This study evaluated the use of hrHPV in situ hybridization (ISH) in cytology cell blocks of cystic neck lesions.MethodsTwenty‐four FNA cases with cell blocks and surgical correlates were evaluated. p16 IHC and hrHPV ISH were assessed on cell blocks (C‐p16 and C‐hrHPV ISH), and hrHPV ISH on surgical samples (S‐hrHPV ISH). All results were classified as negative, positive, or equivocal.ResultsTwo cases were excluded because of insufficient tissue on recut. On the basis of C‐hrHPV ISH cases, 12 were positive, 5 were negative, and 5 were equivocal. All 12 positive C‐hrHPV ISH cases had concordant S‐hrHPV ISH with no false positives. Of the 5 negative C‐hrHPV ISH cases, 4 had concordant S‐hrHPV ISH, and 1 had a discordant S‐hrHPV ISH. Of the 5 equivocal C‐hrHPV ISH cases, S‐hrHPV ISH were both positive and negative. Fourteen cases were equivocal by C‐p16; 9 cases were reliably classified by C‐hrHPV ISH (5 positive, 4 negative; 64%).ConclusionsC‐hrHPV ISH can be reliably used, especially when positive. A negative or equivocal interpretation of C‐hrHPV ISH may warrant repeat testing. Compared to C‐p16, C‐hrHPV ISH is more frequently diagnostic and could be helpful for HPV‐OSCC diagnosis and management.
Numerical method to characterise capsule membrane permeability for controlled drug delivery
Authors: Bielinski Clément , Kaoui Badr 
Published: November 2021

AbstractDesign and characterisation of capsules is not an easy task owing to the multiple involved preparation factors and parameters. Here, a novel method to characterise capsule membrane permeability to solute molecules by an inverse approach is proposed. Transport of chemical species between the capsule core and the surrounding medium through the membrane is described by the Fick's second law with a position‐dependent diffusion coefficient. Solutions are computed in spherical coordinates using a finite difference scheme developed for diffusion in multilayer configuration. They are validated using semi‐analytical solutions and fully three‐dimensional lattice Boltzmann simulations. As a proof of concept, the method is applied to experimental data available in the literature on the kinetics of glucose release and absorption to determine the membrane permeability of capsules. The proposed method is easy to use and determines correctly the permeability of capsule membranes for controlled drug release and absorption applications.
Association of Platelet Thromboxane Inhibition by Low‐Dose Aspirin With Platelet Count and Cytoreductive Therapy in Essential Thrombocythemia
Authors: Tosetto Alberto , Rocca Bianca , Petrucci Giovanna , Betti Silvia , Soldati Denise , Rossi Elena , Timillero Andrea , Cavalca Viviana , Porro Benedetta , Iurlo Alessandra , Cattaneo Daniele , Bucelli Cristina , Dragani Alfredo , Di Ianni Mauro , Ranalli Paola , Palandri Francesca , Vianelli Nicola , Beggiato Eloise , Lanzarone Giuseppe , Ruggeri Marco , Carli Giuseppe , Elli Elena Maria , Priolo Stefania , Randi Maria Luigia , Bertozzi Irene , Loscocco Giuseppe Gaetano , Ricco Alessandra , Specchia Giorgina , Vannucchi Alessandro Maria , Rodeghiero Francesco , De Stefano Valerio , Patrono Carlo ,   for the Aspirin Regimens in EsSential thrombocythemia (ARES) Investigators
Published: November 2021

Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by enhanced platelet production and thrombotic complications. The inhibition of platelet cyclooxygenase (COX) activity by the standard once‐daily aspirin is mostly incomplete due to accelerated thrombopoiesis. The phase II Aspirin Regimens in EsSential thrombocythemia (ARES) trial has recently compared the efficacy of once‐ vs. twice‐ or three‐times daily low‐dose aspirin in inhibiting platelet thromboxane (TX) A2 production, as reflected by serum (s) TXB2 measurements. The present substudy characterized the determinants of the highly variable response to the standard aspirin 100 mg once‐daily regimen in fully compliant patients with ET and the effects of the experimental dosing regimens on response variability. By multivariable analysis, the platelet count (directly) and cytoreductive treatment (inversely) were significantly associated with sTXB2 values in 218 patients with ET. However, the platelet count positively correlated with sTXB2 in patients not being treated with cytoreductive drugs (ρ = 0.51, P < 0.01, n = 84), but not in patients on cytoreduction. Patients in the lowest sTXB2 quartile were older, more often on cytoreductive drugs, had lower platelet count and Janus‐Associated Kinase2 (JAK2)‐V617F allele frequency as compared with patients in the upper sTXB2 quartiles. After 2 weeks of a twice‐ or 3‐times daily aspirin regimen, the association between the platelet count and sTXB2 became similar in cytoreduced and non‐cytoreduced patients. In conclusion, the platelet count appears the strongest determinant of TXA2 inhibition by once‐daily low‐dose aspirin in ET, with different patterns depending of cytoreductive treatment. More frequent aspirin dosing restores adequate platelet inhibition and reduces interindividual variability, independently of cytoreduction.