bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi Simulated Annealing untuk Penentuan Rute pada Jaringan
Authors: Yuliastuti Gusti Eka , Prabiantissa Citra Nurina , Rizki Agung Mustika 
Published: October 2021

Abstract—Recently computer networks are increasingly complex. It needs to be a supporting device for network management such as a router. Router is a device that plays an important role in the routing process. In a router stored information in the form of routing paths, where the information includes data and which routers will be passed. In certain cases, a router can have more than one gateway. This is because the router needs to send data packets to several networks that have different segments. Such cases can be handled by using the appropriate routing path selection rules. The routing problem can be regarded as a traveling salesman problem (TSP), where a mechanism is needed to determine the shortest route to be traversed. The author implements the Simulated Annealing Algorithm because it can produce an optimal solution with light computing, so that the routing process can be more effective and efficient. Index Terms—Computer Network, Routing, Simulated Annealing, Travelling Salesman Problem Abstrak–-Jaringan komputer saat ini semakin kompleks. Perlu adanya suatu perangkat pendukung untuk manajemen jaringan seperti router. Router merupakan perangkat yang berperan penting dalam proses routing. Pada sebuah router tersimpan informasi berupa jalur routing, dimana informasi tersebut mencakup data dan router mana saja yang akan dilewati. Pada kasus tertentu, router dapat memiliki lebih dari satu gateway. Hal ini disebabkan karena router perlu mengirimkan paket data ke beberapa jaringan yang memiliki segmen berbeda. Kasus tersebut dapat ditangani dengan menggunakan aturan pemilihan jalur routing yang tepat. Permasalahan routing dapat dikatakan sebagai suatu permasalahan travelling salesman problem (TSP), dimana diperlukan suatu mekanisme dalam menentukan rute terpendek untuk dilalui. Penulis mengimplementasikan Algoritma Simulated Annealing karena dapat menghasilkan solusi yang optimal dengan komputasi ringan, sehingga proses routing dapat lebih efektif dan efisien. Kata Kunci—Jaringan Komputer, Penentuan Rute, Travelling Salesman Problem, Algoritma Simulated Annealing
Psychometric Validation of a Simplified Version of the Multiple Sclerosis Self-Management Scale
Authors: Rumrill Stuart , Wu Jia-Rung , Iwanaga Kanako , Lee Beatrice , Chan Fong , Pfaller Joseph 
Published: October 2021

PurposeThe purpose of this study was to evaluate the measurement structure of a simplified version of the Multiple Sclerosis Self-Management Scale (MSSMS) in a sample of 256 individuals with multiple sclerosis (MS).MethodsExploratory factor analysis was utilized to uncover meaningful and interpretable factors.ResultsThe study yielded three factors as both meaningful and interpretable (medication compliance, MS knowledge, and health maintenance behavior). These factors are reliable and correlated with functional disability and community participation in the theoretically expected directions.ConclusionResults show the MSSMS to be a promising rehabilitation assessment tool for individuals with MS and rehabilitation counselors to evaluate self-management support needs in the interview, assessment, and rehabilitation planning protocols.
THE EFFECT OF SERVICE QUALITY AND SATISFACTION ON LOYALTY IN MEMBERS OF “KSPPS BMT MANDIRI SEJAHTERA JAWA TIMUR”
Authors: Krismonicha Ferdian Dwi , Prasetyo Ari 
Published: October 2021

ABSTRAKPenelitian bertujuan mengetahui kualitas pelayanan dan kepuasan berpengaruh terhadap loyalitas anggota “KSPPS BMT Mandiri Sejahtera Jawa Timur” secara parsial dan simultan dengan data dari hasil kuisioner secara aksidental dengan sampel 100 anggota BMT dan diuji instrumen. Pengujian regresi berganda Y = a + b1.x1 +b2.x2 menghasilkan persamaan regresi berganda Y = 3,793 + 0,316 + 0,477, uji asumi klasik (normalitas multikoliniearitas, heteroskedastistas), dan uji hipotesis berdasar uji T ditemukan hipotesis pertama dan kedua diterima, kualitas pelayanan dan kepuasan masing-masing memengaruhi loyalitas dengan kualitas pelayanan lebih dominan mempengaruhi loyalitas. Hasil simultan hipotesis uji F kedua variabel bersama-sama berpengaruh terhadap loyalitas.Kata Kunci: Kualitas Pelayanan, Kepuasan, Loyalitas, Baitul Maal Tamwil. ABSTRACTThe purpose of the study is to find out whether service quality and satisfaction affect the loyalty of members of "KS PPS BMT Mandiri Sejahtera East Java" partially and simultaneously with data from the accidental questionnaire results, with a sample of 100 BMT members and tested by using some instruments. The multiple regression test of Y = a + b1.x1 +b2.x2 gave the multiple regression equation of Y = 3.793 + 0.316 + 0.477, and classic assumption test (multicollinearity normality, heteroscedasticity), and hypothesis testing based T- test found that the first and second hypotheses are accepted, and service quality and satisfaction each influence loyalty with service quality more dominantly affects loyalty. The simultaneous results of the two variables of F test hypothesis together have an effect on loyalty.Keywords: Service Quality, Satisfaction, Loyalty, Baitul Maal Tamwil
IMPLEMENTASI HALAL TRACEABILITY SUPPLY CHAIN DENGAN MODEL SUPPLY CHAIN OPERATION REFERENCE (SCOR) INDUSTRI MAKANAN HALAL
Authors: Dilla Zahro Ubay , Fathurohman Muhamad Said 
Published: October 2021

ABSTRAKTujuan dari penelitian ini adalah menggambarkan hasil implementasi dari sistem halal traceability supply chain pada produk makanan halal pengolahan daging di perusahaan Ternaknesia Farm Innovation. Analisis pada penelitian ini menggunakan model Supply Chain Operation Reference (SCOR) sebagai model utama dalam pengembangan halal traceability supply chain. Perusahaan ini tengah mengembangkan sistem jaminan ketelusurah halal (halal traceability supply chain) pada produk daging yang dijual nya dengan membuat model bisnis Ternaknesia 2.0 yang berkelanjutan sebagai perusahaan pertama di wilayah Surabaya Jawa Timur yang memiliki sistem halal traceability. Hasil identifikasi atas Implementasi dari halal traceability supply chain menunjukan bahwa penerapan sistem halal traceability di perusahaan mampu meminimalisir terjadinya ancaman kontaminasi zat haram yang ditelusuri dari implementasi pada proses model SCOR yaitu plan,resource,make, deliver return, dan enable dengan mengembangkan konsep halal dan thoyyib pada produk daging halal yang dijual. Teknologi yang digunakan dalam implementasi pelacakan proses ketertelusuran halal atau halal traceability system yaitu dengan penggunaan label QR Barcode Scan dan didukung penggunakan EPICS code pada produk daging halal yang dijual di perusahaan, sehingga memberikan jaminan ketelusuran halal rantai pasok kepada konsumen. Kata Kunci: halal traceability supply chain dan makanan halal. ABSTRACTThe purpose of this study is to describe the results of the implementation of the halal traceability supply chain system on halal food products for meat processing at the Ternaknesia Farm Innovation company. The analysis in this study uses the Supply Chain Operation Reference (SCOR) model as the main model in the development of halal traceability supply chain. The company is developing a halal traceability supply chain guarantee system for the meat products it sells by creating a sustainable Ternaknesia 2.0 business model as the first company in the Surabaya area of East Java to have a halal traceability system. The results of the identification of the implementation of the halal traceability supply chain show that the implementation of the halal traceability system in the company is able to minimize the threat of contamination of illicit substances traced from the implementation of the SCOR model process, namely plan, resource, make, deliver return, and enable by developing the concept of halal and thoyyib. on halal meat products sold. The technology used in the implementation of tracking the halal traceability system is the use of a QR Barcode Scan label and supported by the use of the EPICS code on halal meat products sold in the company, thus providing guarantees for supply chain halal traceability to consumers.Keywords: halal traceability supply chain and halal meat products.
Co-occurrence of Relapsing Polychondoritis and Autoimmune Thyroid Diseases
Authors: Nakajima Toshiki , Yoshifuji Hajime , Yamano Yoshihisa , Yurugi Kimiko , Miura Yasuo , Maekawa Taira , Yoshida Tsuneyasu , Handa Hiroshi , Ohmura Koichiro , Mimori Tsuneyo , Terao Chikashi 
Published: October 2021

Abstract
Background: Relapsing polychondritis (RP) is a rare inflammatory disease characterized by recurrent inflammation and destruction of cartilageous tissues. RP has characteristics of autoimmune disease and some reports have noted co-occurrence with autoimmune thyroid disease (AITD), consisting of Graves’ disease (GD) and Hashimoto thyroiditis (HT). However there have been no detailed studies on the co-occurrence of RP and AITD. In this study, we aimed to determine whether patients with RP tend to be complicated with AITD. We also analyzed clinical and genetic profiles of patients in whom these diseases co-occur.Methods: We recruited 117 patients with RP and reviewed their medical records. Furthermore, we genotyped Human Leucocyte Antigen (HLA)-A, B Cw, DRB1, DQB1 and DPB1 alleles for 93 of the 117 patients. The prevalence of AITD among the patients with RP was compared with that among the general Japanese population. We also analyzed the clinical and genetic features of the patients with both RP and AITD.Results: The prevalence of GD among the patients with RP was 4.3% (5 among 117 patients), significantly higher than that among Japanese (0.11%) (p=2.44×10-7, binomial test). RP patients with GD tended to have nasal involvement (p=0.023) (odds ratio (OR) 2.58) and HLA-DPB1*02:02 (p=0.035, OR 10.41). We did not find significant enrichment of HT in patients with RP.Conclusions: Patients with RP appear to be at elevated risk of GD. Nasal involvement and HLA-DPB1*02:02 may characterize the subset of RP patients with GD, which may guide attempts to characterize distinct subtype of RP for precision medicine.
Helicobacter Pylori Caga Status and Gastric Mucosa-Associated Lymphoid Tissue Lymphoma: A Systematic Review and Meta-Analysis
Authors: Keikha Masoud , Sahebkar Amirhossein , Yamaoka Yoshio , Karbalaei Mohsen 
Published: October 2021

Abstract
Background
Recent studies have investigated the role of Helicobacter pylori infection in the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma. It is estimated that approximately 0.1% of people infected with H. pylori develop gastric MALT lymphoma. However, the role of the CagA antigen, the highest causative agent of H. pylori, in increasing the risk of gastric MALT lymphoma remains unclear and controversial. A systematic review and meta-analysis were conducted to evaluate the effect of cagA status on the development of gastric MALT lymphoma.
Methods
All articles evaluating the status of the cagA gene in the development of gastric MALT lymphoma were collected using systematic searches in online databases, including PubMed, Scopus, Embase, and Google Scholar, regardless of publication date. The association between cagA and gastric MALT lymphoma was assessed using the odds ratio (OR) summary. In addition, a random-effects model was used in cases with significant heterogeneity.
Results
A total of 10 studies met our inclusion criteria, among which 1,860 patients participated. No association between cagA status and the development of MALT lymphoma (extranodal marginal zone B-cell lymphoma) was found in this study (OR: 1.30; 0.906–1.866 with 95% CIs; I2: 45.83; Q-Value: 12.92). Surprisingly, a meaningful association was observed between cagA status and diffuse large B-cell lymphoma (OR: 6.43; 2.45–16.84 with 95% CIs). We also observed an inverse association between vacA and gastric MALT lymphoma risk (OR: 0.92; 0.57–1.50 with 95% CIs).
Conclusions
It seems that the infection with cagA-positive H. pylori strains does not have a meaningful effect on the gastric MALT lymphoma formation, while translocated CagA antigen into the B cells plays a crucial role in the development of diffuse large B-cell lymphoma.
Predictors of the Relationship Between the Duration of Cancer and Care Time with the Supportive Care Needs of Patients and the Quality of Life of Their Caregivers: A Path Analysis
Authors: Attari Seyedeh Maryam , mahmoodi Zohreh , Nimekari Mozhgan Mohammadzadeh , Nasiri Malihe , taziani Yaghoub Ashouri , Ozgoli Giti 
Published: October 2021

Abstract
Background Breast cancer patients face various material, and the mutual impact of patients and caregivers on each other show the need for further supportive care from the community and family. This study aimed to identify the predictors of the direct and indirect relationships of the duration of cancer and care time with the supportive needs of the patients and the quality of life of their family caregivers.Methods This descriptive-analytical study was carried out on 150 patients and their caregivers in Iran. Data were collected using the Supportive Care Needs Survey-short form (SCNS-SF34), the Caregiver Quality of Life Index-Cancer (CQOLC) scale, and a socio-demographic checklist and were then analyzed in SPSS-24 and Lisrel-8.8 software using descriptive-analytical statistics and path analysis.Results The mean age of the patients and caregivers was 45.76±10.44 and 43.46±9.5, respectively. Based on the test results, the duration of cancer was positively correlated with the total score of supportive needs in both paths (B=0.799). The patients’ sexuality needs had the highest negative correlation with their duration of cancer in the direct path (B=-0.87) and psychological needs the highest negative correlation in the indirect path (B=-0.32). The care time (in hours) had the highest positive correlation with the total score of supportive needs (B=15.6) in both the direct and indirect paths, and the highest positive correlation with physical needs in the direct path (B=10.65). The caregivers’ quality of life had a negative and direct relationship with the duration of cancer (B=-0.27) and there was a positive and direct relationship between care time and the caregivers’ quality of life (B=3.09). Conclusions Duration of cancer and care time had the highest positive correlation with the patients’ supportive needs, and the caregivers’ quality of life had a negative correlation with the duration of cancer and a positive correlation with care time. It is therefore vital to emphasize the design and implementation of supportive care programs for breast cancer patients and their family caregivers.
Leukocyte telomere length and amyotrophic lateral sclerosis: a Mendelian randomization study
Authors: Xia Kailin , Zhang Linjing , Zhang Gan , Wang Yajun , Huang Tao , Fan Dongsheng 
Published: October 2021

Abstract
Background
Observational studies have suggested that telomere length is associated with amyotrophic lateral sclerosis (ALS). However, it remains unclear whether this association is causal. We employed a two-sample Mendelian randomization (MR) approach to explore the causal relationship between leukocyte telomere length (LTL) and ALS based on the most cited and most recent and largest LTL genome-wide association studies (GWASs) that measured LTL with the Southern blot method (n = 9190) and ALS GWAS summary data (n = 80,610). We adopted the inverse variance weighted (IVW) method to examine the effect of LTL on ALS and used the weighted median method, simple median method, MR Egger method and MR PRESSO method to perform sensitivity analyses.
Results
We found that genetically determined longer LTL was inversely associated with the risk of ALS (OR = 0.846, 95% CI: 0.744–0.962, P = 0.011), which was mainly driven by rs940209 in the OBFC1 gene, suggesting a potential effect of OBFC1 on ALS. In sensitivity analyses, that was confirmed in MR Egger method (OR = 0.647,95% CI = 0.447–0.936, P = 0.050), and a similar trend was shown with the weighted median method (OR = 0.893, P = 0.201) and simple median method (OR = 0.935 P = 0.535). The MR Egger analyses did not suggest directional pleiotropy, showing an intercept of 0.025 (P = 0.168). Neither the influence of instrumental outliers nor heterogeneity was found.
Conclusions
Our results suggest that genetically predicted longer LTL has a causal relationship with a lower risk of ALS and underscore the importance of protecting against telomere loss in ALS.
Implementation of Real Time Hybrid Simulation Based On GPU Computing
Authors: Tang Zhenyun , Dong Xiaohui , Li Zhenbao , Du Xiuli 
Published: October 2021

Abstract
With combination of physical experiment and numerical simulation, real-time hybrid simulation (RTHS) can enlarge the dimensions of testing specimens and improve the testing accuracy. However, due to the limitation of computing capacity, the maximum degrees of freedom for numerical substructure are less than 7000 from the reported RTHS testing. It cannot meet the testing requirements for evaluating the dynamic performance of large and complex engineering structures. Taking advantages of parallel computing toolbox (PCT) in Matlab and high-performance computing of graphics processing unit (GPU). A RTHS framework based on MATLAB and GPU was established in this work. Using this framework, a soil-structure interaction system (SSI) was tested by a shaking table based RTHS. Meanwhile, the dynamic response of this SSI system was simulated by finite element analysis. The comparison of simulation and testing results demonstrated that the proposed testing framework can implement RTHS testing successfully. Using this method, the maximum degrees of freedom for numerical substructure can reach to 27,000, which significantly enhance the testing capacity of RTHS testing for large and complex engineering structures.
Endoscopic Endonasal Supraoptic and Infraoptic Approaches for Complex “Parasuprasellar” Lesions: Surgical Anatomy, Technique Nuances, and Case Series
Authors: Bao You Yuan , Yang You Qing , Zhou Lin , Xie Shen Hao , Wu Xiao , Ding Han , Wu Jie , Xiao Li Min , Yang Le , Tang Bin , Hong Tao 
Published: October 2021

Abstract
Surgical management of lesions involving the lateral area of the suprasellar region, including the lateral aspect of the planum sphenoidale and a tight junction region of the optic canal (OC), the anterior clinoid process (ACP), and the internal carotid artery (ICA) and its dural rings, is extremely challenging. Here, the authors introduce two novels endoscopic endonasal supraoptic (EESO) and endoscopic endonasal infraoptic (EEIO) approaches to access these regions, namely, “parasuprasellar” area. Surgical simulation of the EESO and EEIO approaches to the parasuprasellar area was conducted in 5 silicon-injected specimens. The same techniques were applied in 12 patients involving the parasuprasellar area.The EESO and EEIO approaches can be used independently or in combination, but are more often employed as a complement to the endoscopic endonasal midline approach and transcavernous approach. In clinical application, the EESO and EEIO approaches were successfully performed in 12 patients harboring tumors and multiple aneurysms involving the parasuprasellar area. Gross total and subtotal tumor resection were achieved in 9 patients and 1 patient, respectively. For two patients with multiple aneurysms, the lesions were clipped selectively according to location and size. Visual acuity improved in 7 patients, remained stable in 4, and deteriorated in only 1. No postoperative intracranial infection or ICA injury occurred in this series. The EESO and EEIO approaches can be combined with the current endoscopic endonasal midline approach and transcavernous approach to remove extensive pathologies involving the intrasellar, suprasellar, sphenoid, and cavernous sinuses and even bifurcation of the ICA.
ULTRARAM™: a low-energy, high-endurance, compound-semiconductor memory on silicon
Authors: Hodgson Peter , Lane Dominic , Carrington Peter , Delli Evangelia , Beanland Richard , Hayne Manus 
Published: October 2021

Abstract
ULTRARAM is a non-volatile memory with the potential to achieve fast, ultralow-energy electron storage in a floating gate accessed through a triple-barrier resonant tunneling heterostructure. Here we report its implementation on a Si substrate; a vital step towards cost-effective mass production. Sample growth using molecular beam epitaxy commenced with deposition of an AlSb nucleation layer to seed the growth of a GaSb buffer layer, followed by the III-V memory epilayers. Fabricated single-cell memories show clear 0/1 logic-state contrast after ≤10-ms duration program/erase pulses of ~2.5 V, a remarkably fast switching speed for 10- and 20-µm devices. Furthermore, the combination of low voltage and small device capacitance per unit area results in a switching energy that is orders of magnitude lower than dynamic random access memory and flash, for a given cell size. Extended testing of devices revealed retention in excess of 1000 years, and degradation-free endurance of over 107 program/erase cycles, surpassing very recent results for similar devices on GaAs substrates.
Nanoliposome-Encapsulated Phenolic Rich Fraction From Alcea Rosea as a Dietary Phytobiotic in Mice Challenged by Escherichia Coli
Authors: Hassirian Niloofar , Karimi Ehsan , Oskoueian Ehsan 
Published: October 2021

Abstract
Purpose
This research was performed to evaluate the antibacterial and health-promoting potentials of the nanoliposome-encapsulated phenolic rich fraction (PRF) from Alcea rosea leaves as a dietary phytobiotic in mice challenged by enteropathogenic Escherichia coli (E. coil; O157: H7).
Method:
The PEF was encapsulated in nanoliposomes (PEF-NLs) and the phenolic profiling of PEF-NLs was confirmed by HPLC. Then 40 white male balb/c mice at four treatment groups were provided and antibacterial potential of PEF-NLs were assessed by measuring the mice blood parameters and liver lipid peroxidation in mice infected by E. coli. Finally, the expression of cyclooxygenase 2 (COX2), inducible nitric oxide synthase (iNOS), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were determined in miceʼs ileum tissues. Meanwhile, relative fold changes in the ileum population of E. coli was analyzed using Real time PCR.
Results
The overall results demonstrated that the nanoliposome-loaded PRF contained gallic acid, salicylic acid, pyrogallol, cinnamic acid, catechin, naringin, ferulic acid. The E. coil challenge in mice impaired the weight gain, food intake, liver enzymes, lipid peroxidation, morphometric characteristics of the ileum, up-regulated the inflammatory genes (COX2, iNOS), down-regulated the antioxidant-related genes (SOD and GPx) and increased the population of E. coil in the ileum. The dietary inclusion of nonencapsulated PRF and nanoliposome-encapsulated PRF at the concentration of 10 mg TPC/kg BW/day improved these parameters however the nanoliposome-encapsulated PRF appeared to be more effective as compared to nonencapsulated PRF in improving the health parameters in mice.
Conclusion
Consequently, the nanoliposome-encapsulated PRF could play a critical role as a promising phytobiotic against E. coil infection in mice.