bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Interaction With Relapsed Partner Facilitates Cocaine Relapse in Rats
Authors: Meng Shiqiu , Yan Wei , Liu Xiaoxing , Gong Yimiao , Tian Shanshan , Wu Ping , Sun Yan , Shi Jie , Lu Lin , Yuan Kai , Xue Yanxue 
Published: October 2021

Social factors strongly contribute to drug use and relapse, and epidemiological studies have found that members of peer groups influence each other to use drugs. However, previous animal models mostly failed to incorporate social factors and demonstrate the effects of social partners on drug addiction and relapse. In the present study, we investigated the transfer of relapse to cocaine seeking between drug-addicted partners in rats. Male Sprague–Dawley rats were pair-housed and subjected to training and extinction of cocaine self-administration and conditioned place preference (CPP). 24 h after extinction test, the targeted rats interacted with a cocaine-primed (relapsed) partner or stranger, or saline-injected (unrelapsed) partner for 30 min, after which the targeted rats were tested for drug seeking behavior. We found that social interaction with a relapsed partner increased drug seeking behavior in cocaine self-administration and CPP models in rats, while social interaction with an unrelapsed partner or relapsed stranger had no effect on cocaine seeking. Moreover, the effect of social interaction on cocaine seeking could last for at least 1 day. Our findings demonstrate a facilitation effect of relapsed social partners on drug relapse in rats and provide a novel animal model for social transfer of drug relapse.
New Challenges Resulting From the Loss of Function of Nav1.4 in Neuromuscular Diseases
Authors: Nicole Sophie , Lory Philippe 
Published: October 2021

The voltage-gated sodium channel Nav1.4 is a major actor in the excitability of skeletal myofibers, driving the muscle force in response to nerve stimulation. Supporting further this key role, mutations in SCN4A, the gene encoding the pore-forming α subunit of Nav1.4, are responsible for a clinical spectrum of human diseases ranging from muscle stiffness (sodium channel myotonia, SCM) to muscle weakness. For years, only dominantly-inherited diseases resulting from Nav1.4 gain of function (GoF) were known, i.e., non-dystrophic myotonia (delayed muscle relaxation due to myofiber hyperexcitability), paramyotonia congenita and hyperkalemic or hypokalemic periodic paralyses (episodic flaccid muscle weakness due to transient myofiber hypoexcitability). These last 5 years, SCN4A mutations inducing Nav1.4 loss of function (LoF) were identified as the cause of dominantly and recessively-inherited disorders with muscle weakness: periodic paralyses with hypokalemic attacks, congenital myasthenic syndromes and congenital myopathies. We propose to name this clinical spectrum sodium channel weakness (SCW) as the mirror of SCM. Nav1.4 LoF as a cause of permanent muscle weakness was quite unexpected as the Na+ current density in the sarcolemma is large, securing the ability to generate and propagate muscle action potentials. The properties of SCN4A LoF mutations are well documented at the channel level in cellular electrophysiological studies However, much less is known about the functional consequences of Nav1.4 LoF in skeletal myofibers with no available pertinent cell or animal models. Regarding the therapeutic issues for Nav1.4 channelopathies, former efforts were aimed at developing subtype-selective Nav channel antagonists to block myofiber hyperexcitability. Non-selective, Nav channel blockers are clinically efficient in SCM and paramyotonia congenita, whereas patient education and carbonic anhydrase inhibitors are helpful to prevent attacks in periodic paralyses. Developing therapeutic tools able to counteract Nav1.4 LoF in skeletal muscles is then a new challenge in the field of Nav channelopathies. Here, we review the current knowledge regarding Nav1.4 LoF and discuss the possible therapeutic strategies to be developed in order to improve muscle force in SCW.
Design and Implementation of a Contemporary Health Administration Program for Health Managers
Authors: Khalil Hanan , Liu Chaojie 
Published: October 2021

Background: While there are core competencies required in health administration programs, little is known about how they are taught in health administration programs to support/change practises. This discussion paper describes an educational innovation to design a contemporary Master of Health Administration program to meet the current needs of health managers in Australia based on evidence-based practise.Method: A detailed gap analysis of health managers educational needs was undertaken with various stakeholders to design a contemporary health managers' program. Stakeholders surveyed in the course design included prospective students, international students' agencies, prospective employers, Alumni evaluation, mapping of health managers courses in Australia and faculty feedback. An integrative pedagogical approach was used to implement the program into action.Results: Various themes were emerged from the stakeholder consultations including the importance of basic knowledge of key subjects and the significance of learning new skills such as strategic planning and emotional intelligence in the workplace. The integrative pedagogical approach used is based on adult teaching principles, which were identified by Knowles. The subjects in the new course incorporate several knowledge-based presentations along with interactive activities, including use of general ability-based outcomes to define learning opportunities, case-based and problem-based learning, experiential learning, and comprehensive assessments.Conclusion: The results of this intensive consultation led to the design of a contemporary Master of Health Administration Course that included eight core subjects and multiple options of specialisations for students to choose from. Examples of specialisations include aged care and ageing, health promotion, data for decision making, public health, international development and Health Strategy and decision making.
Small Bowel Intussusception Due to Rare Cardiac Intimal Sarcoma Metastasis: A Case Report
Authors: Chiarelli Marco , Zago Mauro , Tagliabue Fulvio , Burati Morena , Riva Cristina , Vanzati Alice , Dainese Emanuele , Gabrielli Francesco , Guttadauro Angelo , De Simone Matilde , Cioffi Ugo 
Published: October 2021

Background: Intimal sarcomas are rare malignant mesenchymal tumors arising from the heart and large blood vessels. Their intraluminal growth leads to vascular obstructive symptoms and peripheral neoplastic embolization. Direct infiltration of the lungs or metastases to the pulmonary system, occur in 40% of cases and extrathoracic spread is frequent, also in presentation. Intussusception is an unusual event in adults, accounting for &lt;5% of bowel obstructions. In most cases it is caused by a malignancy and requires surgical resection.Case Presentation: We describe a rare case of a 50-year-old man suffering of bowel obstruction due to intussusception sustained by a small bowel metastasis of a primary cardiac intimal sarcoma. One year and a half before the onset of abdominal symptoms, a grade II intimal sarcoma was removed from his left atrium and consequently he followed a chemotherapy protocol. Four months later a CT scan revealed local recurrence. Eighteen months after heart surgery he referred to the ER with abdominal pain. CT scan showed an ileal intussusception and the patient was scheduled for surgery. A tract of 10 cm ileus was removed containing an intramural polypoid solid mass. Histological analyses revealed a grade II intimal sarcoma consistent with his first diagnosis.Conclusion: Primary heart tumors are late found and often partially resected, therefore metastatic pathways are to be expected. Adult small bowel intussusception is a rare event and caused by a malignancy in one third of cases. Therefore, our recommendation is to always resect the tract involved in order to perform a proper diagnosis.
Whole-Genome Sequencing Analysis of a stx-Negative Escherichia coli O63:H6 Isolate Associated with Hemolytic Uremic Syndrome
Authors: Kim Tae Yeul , La Tae-Min , Kim Taesoo , Yun Sun Ae , Lee Sang-Won , Huh Hee Jae , Lee Nam Yong 
Published: October 2021

Shiga toxin-encoding genes (stx) of enterohemorrhagic Escherichia coli (EHEC) can be lost during infection or in vitro cultivation, and in clinical practice, it is difficult to distinguish EHEC that have lost stx (EHEC-LST) from enteropathogenic E. coli (EPEC), as both are stx-negative and eae-positive. In this study, we performed whole-genome sequencing (WGS) of a stx-negative, eae-positive E. coli O63:H6 isolate from a child with hemolytic uremic syndrome and compared its genome with those of nine E. coli O63:H6 strains in public databases. Virulence gene profiles were analyzed and core-genome multilocus sequence typing (cgMLST) was conducted. The virulence gene profile of our isolate was consistent with EHEC, except for the absence of stx, and the isolate clustered with seven EHEC strains but was distant from two EPEC strains in cgMLST. In genome alignment, our isolate exhibited a high nucleotide identity with EHEC strain 377323_2f but displayed a gap corresponding to the stx-harboring prophage sequence. Overall, our isolate was genetically closely related to EHEC strains, consistent with this being an EHEC-LST strain. As EHEC-LST may be misdiagnosed as EPEC in routine laboratories, comparative genomic analysis using WGS can be useful to determine whether stx-negative and eae-positive isolates are EHEC-LST or EPEC.
LISTA ANOTADA DE LAS ESPECIES DE EUPHORBIACEAE PARA EL QUINDÍO
Authors: Maya-Lastra Carlos Alonso , Agudelo-Henao Carlos Alberto 
Published: October 2021

Se realizó el estudio taxonómico de la familia Euphorbiaceae en el departamento del Quindío, Colombia, el cual fue desarrollado con el fin de conocer las especies presentes en la región, para lo cual se revisaron y determinaron 423 ejemplares de la colección del Herbario Universidad del Quindío (HUQ). Para esta región se reconocieron 16 géneros, de los cuales Euphorbia y Acalypha reportaron el mayor número de especies, 9 y 7 respectivamente, seguidos por Croton (5 spp.), Dalechampia (3 spp.), Alchornea (2 spp.), Mabea (2 spp.), Jatropha (2 spp.) y Chamaesyce (2 spp.) con un número menor de especies y 8 géneros monoespecíficos, Ricinus, Dysopsis, Tetrorchidium, Manihot, Codiaeum, Caperonia, Plukenetia y Sapium. A nivel de especies se encontraron 40 en total, de las cuales 14 fueron nuevos registros para el departamento, destacnadose entre estas Dalechampia canescens, D. cissifolia, Plukenetia volubilis y Croton xalapensis, siendo esta última un nuevo registro para Colombia. Se confirmó además la presencia de Acalypha platyphylla y de A. setosa en la zona y se identificó a A. diversifolia, A. macrostachya y Euphorbia heterophylla como las especie con mayor distribución en el departamento, encontrándonse en los 12 municipios, y a Dalechampia canescens, Dysopsis paucidentata y Euphorbia peplus como las de menor distribución, ya que sólo se localizan en uno o dos municipios.
OBJETIVOS DE CALIDAD DEL AGUA EN CUENCAS HIDROGRAFICAS: PERSPECTIVAS, DESAFIOS E INSTRUMENTOS DE GESTION
Authors: Lozano-Sandoval Gabriel , Pulido-Velázquez Manuel , Álvarez Joaquín Andreu 
Published: October 2021

El continuo e implacable vertido de aguas residuales generados por la mayoría de los usos del agua en cuencas hidrográficas conlleva a la degradación de los ríos en muchas cuencas en el mundo. A pesar de los esfuerzos gubernamentales y no gubernamentales por la descontaminación de las aguas residuales en las cuencas hidrográficas, estos no han sido coordinados dentro de una valoración integral de acuerdo a las condiciones en muchas de estas.
El presente artículo se refiere a las perspectivas, desafíos e instrumentos de gestión para alcanzar Objetivos de Calidad del Agua (OCA) en cuencas hidrográficas. Se presenta un análisis y reflexión sobre la panorámica internacional, nacional y regional. Se plantean desafíos a que se enfrentan las autoridades ambientales para alcanzar dichos objetivos, tales como: variabilidad espacio-temporal de la contaminación, discontinuidad y/o confiabilidad de la información, y aspectos socioeconómicos. Se describen algunos OCA en una cuenca española, según la Directiva Marco Europea del Agua (DMA) y otra colombiana. Se proponen instrumentos económicos, jurídicos y herramientas de apoyo a la decisión para que las autoridades ambientales aborden la problemática desde una Gestión Integral de Recursos Hídricos (GIRH), de cara a alcanzar los OCA fijados en dichas cuencas.
Technology consideration in tennis umpiring: replacing the humans
Authors: Carboch Jan 
Published: October 2021

New technologies step into sports refereeing, officiating, or umpiring. This technology can assist humans to avoid blunders or errors. However, in tennis, this technology now starts to replace humans, i.e. the line umpires. In this letter, we try to provide insight into potential problems, that this technology brings, but also we try to provide its benefits. We offer considerations from the umpire (human) view. It is not very clear and we consider it still in a grey zone, what are the next best steps, even though it seems that the new technology implementation is unavoidable. In this letter, we focus on tennis line umpires, because technology is replacing them now. Therefore, would like to encourage and call for more research on this currently hot topic.
Perilaku Premature Sign Off atas Prosedur Audit Serta Kaitannya dengan Time Pressure dan Audit Risk
Authors: Syah Arzal , Imam Muh. Abdi , Hamida Hamida 
Published: October 2021

AbstractThe practice of premature sign off on audit procedures will directly affect the quality of the audit report produced by the auditor, because if one of the steps in the audit procedure is omitted, the possibility of the auditor making wrong judgments will be higher. This study aims to empirically prove the effect of time pressure and audit risk on premature sign off behavior on audit procedures. The population of this study is the auditor in the public accounting firm in Makassar City, Indonesia. Sample selection using census sampling technique. The results of this study indicate that time pressure tends to increase their efforts to prematurely terminate audit procedures (Premature sign Off). Auditors who perceive high audit risk tend to prematurely terminate audit procedures. When the auditor determines that the materiality inherent in the audit procedure is low, there is a tendency for the auditor to ignore the audit procedure because the auditor considers that if there is a material misstatement in the implementation of the audit procedure, the value is not material so that the auditor conducts premature sign off behavior.Keywords: Audit Risk, Premature Sign Off, and Time Pressure AbstrakPraktik premature sign off atas prosedur audit, akan berpengaruh secara langsung terhadap kualitas laporan audit yang dihasilkan oleh auditor, sebab apabila salah satu langkah dalam prosedur audit dihilangkan maka kemungkinan auditor dalam membuat judgment yang salah akan semakin tinggi. Penelitian ini bertujuan untuk membuktikan secara empiris pengaruh antara time pressure dan audit risk terhadap perilaku premature sign off atas prosedur audit. Populasi dari penelitian ini adalah auditor di kantor akuntan publik yang ada di Kota Makassar, Indonesia. Pemilihan sampel menggunakan teknik sampling sensus. Hasil dari penelitian ini menunjukkan bahwa time pressure, cenderung meningkatkan usahanya untuk melakukan penghentian secara prematur prosedur audit (Premature sign Off). Auditor yang merasakan risiko audit yang tinggi cenderung untuk melakukan penghentian secara prematur prosedur audit. Ketika auditor menetapkan bahwa materialitas yang melekat pada prosedur audit rendah maka terdapat kecenderungan auditor untuk mengabaikan prosedur audit dikarenakanan auditor menganggap jika terdapat salah saji material pada pelaksanaan prosedur audit nilainya tidaklah material sehingga auditor melakukan perilaku premature sign off.Kata Kunci: Audit Risk, Premature Sign Off, Time Pressure
The Economic Thought of Syeikh al Mutawalli Al-Sya'rawi from His Book of 'Tafsir Al-Sya'rawi'
Authors: Noh Mohd Shahid Bin Mohd 
Published: October 2021

Syeikh al-Mutawalli al-Sya'rawi is a prominent muslim Egyptian scholar in his era. He had King Hammad Price as an appreciation on his contribution of ideas and thoughts towards islamic spiritual development and yet he became well known in Muslim world, particular in Arab countries through his tafsir lesson, where eventually been written and complied in volume of books, namely as Tafsir al-Sya'rawi. Besides producing the ideas on aqidah, feqh and tasawwuf, he also included in his words some of the economic thought were could be derived from his books and lectures. This paper aims to explore numbers of his economic thought mobilizing the analysis content methodology from his tafsir, particularly in Surah al-Baqarah. As a result, this study finds that he had shown consistent ideas in supportingshari’ah laws in promoting sadaqahandinfaq, sharingrizq, combatting gambling andriba, strengthening zakat roles and enforcing debt etiquette as mentioned in Al-Quran by giving economic reasons behind the elements said.
Financial Distress Analysis Using Altman Z-Score Model In Sharia Banking In Indonesia
Authors: Setiawan Firman 
Published: October 2021

This study is conducted to explain the risk of financial failure that may occur in Sharia banking which is known asfinancial distress. Quantitative data in the formof financial ratios fromseveral Islamic banks which are the object of the study were analyzed using Altman Z- score model. After analyzing it, it is known that at Bank BRI Syariah Inc, the company experienced financial distress in 2015, in the following year the company experienced improvementthus in 2016-2019, the company was in good health. Bank BTPN Syariah Inc in 2015-2019 was in a good condition, which means that there was no financial distress or was in a gray area position. Bank Syariah Mandiri Inc experienced financial distress in 2015-2019, which means that during that time the company was in a gray area position
THE STRUCTURE OF GRAPHS ON \(n\) VERTICES WITH THE DEGREE SUM OF ANY TWO NONADJACENT VERTICES EQUAL TO \(n-2\)
Authors: An Do Nhu 
Published: October 2021

Let \(G\) be an undirected simple graph on n vertices and \(\sigma^2(G)=n-2\) (degree sum of any two non-adjacent vertices in \(G\) is equal to \(n-2\)) and \(\alpha(G)\) be the cardinality of an maximum independent set of \(G\). In \(G\), a vertex of degree \((n-1)\) is called total vertex. We show that, for \(n\geq3\) is an odd number then \(\alpha(G)=2\) and \(G\) is a disconnected graph; for \(n\geq4\) is an even number then \(2\leq\alpha(G)\leq(n+2)/2\), where if \(\alpha(G)=2\) then \(G\) is a disconnected graph, otherwise \(G\) is a connected graph, \(G\) contains \(k\) total vertices and \(n-k\) vertices of degree \(\delta=(n-2)/2\), where \(0\leq k\leq(n-2)/2\). In particular, when \(k=0\) then \(G\) is an \((n-2)/2\)-Regular graph.
A RANCANG BANGUN ALAT PERAGA SISTEM OILY WATER SEPARATOR DI KAPAL KM. DOROLONDA
Authors: Helmi Iqbal , Amad Narto  , Mashudi Rofik  
Published: October 2021

Pada era modern di dunia kemaritiman ini proses pembelajaran terkait permesinan kapal sangat diperlukan dan sangat penting untuk dikuasai peserta didik. Sehingga banyak digunakan metode pembelajaran yang efektif salah satunya adalah metode pembelajaran dengan menggunakan alat peraga permesinan diatas kapal, maka dari itu penelitian ini bertujuan untuk mengetahui bagaimana cara membuat alat peraga dan untuk mengetahui prinsip kerja dari alat peraga serta untuk mengetahui manfaat yang didapatkan dari alat peraga. Jenis alat peraga sitem oily water separator di atas kapal. Metode yang digunakan yaitu Research and Development, merupakan proses atau langkah-langkah untuk mengembangkan suatu produk yang sudah ada, baik itu perangkat keras maupun perangkat lunak. Model dalam penelitian pengembangan ini adalah model procedural yaitu menggariskan pada langkah-langkah pembuatan yang terpapar secara urut dan bertahap dari proses awal hingga akhir.
Kata kunci: Alat peraga, Oily Water Separator, modul elektronika, Timmer Delay Relay
PENGARUH KINERJA KETARUNAAN TERHADAP TINGKAT RESELIANCE TARUNA DI GEDUNG PEMBINAAN KARAKTER POLITEKNIK BUMI AKPELNI
Authors: Widodo B.L Hentri , Tini Utami  , Eviana Diah Kusumawati  
Published: October 2021

Penelitian ini bertujuan untuk melihat kondisi nyata tingkat kinerja ketarunaan dan kemampuan reseliance di gedung pembinaan karakter Politeknik Bumi Akpelni, serta mendiskripsikan tentang pengaruh kinerja ketarunaan terhadap tingkat reseliance.Penelitian ini diharapkan nantinya memberikan masukan dan atau solusi serta penerapan praktis dalam mengatasi kinerja ketarunaan agar menjadikan lebih baik lagi juga peningkatan kemampuan reseliance taruna di gedung pembentukan dan pembinaan karakter Politeknik Bumi Akpelni. Populasi dalam penelitian ini adalah taruna/taruni angkatan 56 dengan jumlah 370 orang yang melaksanakan pembentukan dan pembinaan karakter di gedung Pembinaan dan Pembentukan Karakter Politeknik Bumi Akpelni.Pengumpulan data dengan metode kuisioner.Uji intrumen ini dilakukan terhadap 79 taruna/ taruni angkatan 56 prodiNautika, Teknika dan KPN. Analisi data yang digunakan adalah teknik analisis regresi. Hasil penelitian ini adalah (1) Berdasarkan uji hipotesis parsial/ uji T diperoleh hasil bahwa kinerja ketarunaan berpengaruh positif signifikan terhadap tingkat reseliance (2) Sumbangan efektif kinerja ketarunaan terhadap reseliance taruna sebesar 13,9 persen.
EFL Learners’ Perceptions on ZOOM Application in the Online Classes
Authors: Nuraziza Nadila , Oktaviani Lulud , Sari Fatimah Mulya 
Published: October 2021

Pandemic Covid-19 brings impactful aspects for several sectors, especially in the education sector. The teaching and learning process has shifted to online learning. It quite challenges the teachers as well as the students to fully support the success of the online classes.Teachers are required to be more creative in delivering the learning materials that will be given to their students. Meanwhile, students are encouraged to be autonomous learners. This paper aims to investigate the students’ perceptions toward the implementation of the ZOOM application to support the online learning process and explore how this application gives a new shape in the educational industry. The qualitative approach was chosen for this study. The data were obtained from questionnaires and interviews. Based on the findings, there are some perceptions about the implementation of ZOOM to support online learning. The result showed that most students thought implementation of e-learning should be improved continuously. Surprisingly, it gave significant changes toward the learning and teaching process, especially during covid-19
itself.