bluuebunny/crossref_metadata_2025_split huggingface dataset:
AULAS EM TEMPOS DE PANDEMIA: UM RELATO DE EXPERIÊNCIA NO CURSO DE LICENCIATURA EM QUÍMICA DO IFPB
Authors: Sousa Thaiane Freitas Brito de , Araújo Jéssica Mayara Vieira de , Guedes Ana Karolina Vieira de Lima , Do Nascimento Maria Helena Monteiro , Santos Keliana Dantas 
Published: May 2021

Este artigo trata-se de um relato de experiência com o principal objetivo de discorrer sobre a vivência de quatro discentes do curso superior de Licenciatura em Química do Instituto Federal de Educação, Ciência e Tecnologia da Paraíba (IFPB) campus João Pessoa, durante o período de oferta das aulas não presenciais devido à pandemia de Covid-19. O curso de Licenciatura em Química, seguindo as orientações institucionais, estabeleceu as divisões das aulas por blocos, de modo a garantir uma melhor organização tanto para docentes quanto para os discentes. Neste trabalho, fizemos análise das atividades remotas ofertadas no bloco I, com início no dia 08 de setembro de 2020 e término em 09 de outubro de 2020, das seguintes disciplinas: Estágio Supervisionado III e o IV, Físico-química II e Química Ambiental, catalogadas neste trabalho como disciplinas práticas, exatas e teóricas, respectivamente. Neste contexto, foram elencadas as seguintes categorias de análise: duração e organização das aulas, metodologia do professor, incluindo recursos didáticos e avaliação da disciplina. Diante das características de cada disciplina, também analisamos como tem sido o acompanhamento dos componentes curriculares de modo geral pelas discentes. Dessa forma, colocamos em pauta os principais desafios que essa modalidade de ensino nos proporcionou face à nova realidade acadêmica,o que nos trouxe a reflexão que há um esforço mútuo de ambas as partes, tanto do professor quanto do aluno, mas apesar disto, dificilmente serão apagados os prejuízos causados durante este período sem aulas presenciais e principalmente sem atividades práticas para nós estudantes de Licenciatura em Química, no ambiente de laboratório e na atuação em sala de aula como estagiárias.
Development and validation of a patient face-mounted, negative-pressure antechamber for reducing exposure of healthcare workers to aerosolized particles during endonasal surgery
Authors: Lee Mark , Rivera-Rosario Hazel T. , Kim Matthew H. , Bewley Gregory P. , Wang Jane , Warhaft Zellman , Stylman Bradley , Park Angela I. , MacMahon Aoife , Kacker Ashutosh , Schwartz Theodore H. 
Published: May 2021

OBJECTIVE
The authors developed a negative-pressure, patient face-mounted antechamber and tested its efficacy as a tool for sequestering aerated particles and improving the safety of endonasal surgical procedures.

METHODS
Antechamber prototyping was performed with 3D printing and silicone-elastomer molding. The lowest vacuum settings needed to meet specifications for class I biosafety cabinets (flow rate ≥ 0.38 m/sec) were determined using an anemometer. A cross-validation approach with two different techniques, optical particle sizing and high-speed videography/shadowgraphy, was used to identify the minimum pressures required to sequester aerosolized materials. At the minimum vacuum settings identified, physical parameters were quantified, including flow rate, antechamber pressure, and time to clearance.

RESULTS
The minimum tube pressures needed to meet specifications for class I biosafety cabinets were −1.0 and −14.5 mm Hg for the surgical chambers with (“closed face”) and without (“open face”) the silicone diaphragm covering the operative port, respectively. Optical particle sizing did not detect aerosol generation from surgical drilling at these vacuum settings; however, videography estimated higher thresholds required to contain aerosols, at −6 and −35 mm Hg. Simulation of surgical movement disrupted aerosol containment visualized by shadowgraphy in the open-faced but not the closed-faced version of the mask; however, the closed-face version of the mask required increased negative pressure (−15 mm Hg) to contain aerosols during surgical simulation.

CONCLUSIONS
Portable, negative-pressure surgical compartments can contain aerosols from surgical drilling with pressures attainable by standard hospital and clinic vacuums. Future studies are needed to carefully consider the reliability of different techniques for detecting aerosols.
Dandy’s hemispherectomies: historical vignette
Authors: Jusue-Torres Ignacio , Prabhu Vikram C. , Jones G. Alexander 
Published: May 2021

To better understand Walter Dandy’s intentions and the historical context of his work on hemispherectomy, the authors reviewed his original 1928 publication. Gliomas were considered incurable at that time. Presuming that the loss of motor function denoted a lack of useful tissue in that hemisphere, he pioneered radical removal of the involved cerebral hemisphere. Of the 5 patients operated on by Dandy, 1 died within 48 hours of hemorrhage because of a displaced vascular clip; 1 died of pneumonia in 2 weeks; 2 died of tumor recurrence, at 3 months and 3.5 years, respectively; and a fifth patient was lost to follow-up beyond the 2nd postoperative week.
The authors queried the Thomson Reuters Web of Science and Scopus. A total of 88 papers fulfilled inclusion criteria. Half of these papers (44/88) were published after 2012. Only 11% of papers (10/88) quoted Dandy’s paper accurately; half of them were published before 1997. Most publications (76% [67/88]) quoted Dandy incorrectly, all of them from 1997 and later. In the remaining 11 papers (13%), the accuracy of the quotes was unclear. The authors found a trend toward more accurate citation in earlier papers.
Critically reviewing Dandy’s report, with an understanding of the historical context, allows a better understanding of his intentions and the value of his contribution.
Nonhomogeneous Stochastic Automata
Authors: Janicki Sławomir 
Published: May 2021

In this note we consider a nonhomogeneous Markov chain type stochastic automaton which is a generalization of Bartoszyński’s stochastic automaton. The latter is a generalization of the Pawlak’s known machine in a stochastic direction. By nonhomogeneous stochastic automaton we mean a system ⟨ T, α, {A(n), n ⩾ 1}⟩, where T is a finite nonempty set, α, is an initial distribution on T, and {A(n), n ⩾ 1} is a matrix sequence whose every element is a stochastic matrix called a transition probability matrix. If A(n) = A for all n ⩾ 1, then we obtain Bartoszyński’s automaton. The sequence (ti0, ti1, …), tij ∈ T, j = 0, 1, 2, … is called a word of automata if α(ti0) > 0 and A(k)(tik-1, tik) > 0 for every k ⩾ 1. The goal of this note is to give necessary and sufficient conditions for the existence of an extension and a shrinkage of the automata under consideration. These problems for T, A were considered for the first time by Bartoszyński. The shrinkage problem deals with the existence of a stochastic automaton which generates only all sequences of states of T which are simultaneously generated by two given automata while the extension problem treats of the existence of a stochastic automaton which generates all sequences of states of which are generated by at least one of two given automata. Moreover, we introduce some new notions: attainable state, concordance of automata in a wide and a narrow sense, which help us to solve the problems mentioned above.
Tasks of Voluntary Rescue Teams in Extreme Weather Situations
Authors: Teknős László 
Published: May 2021

The occurrence of weather phenomena associated with extreme precipitation, temperatures and winds are not unusual in the history of meteorology in Hungary. However, in view of the characteristics of damages, it can be ascertained that they are usually witnessed at local (settlement) level; they damage the natural and built environment, jeopardise the safety of people and their financial resources. This greatly burdens the human resources of forces designated to respond to these anomalies, also their deployments, logistics and the management system of their equipment. The current Disaster Management Act created a resolution to this tension between damage prevention, response and rescue by declaring the possibilities of involving the voluntarism of citizens in organised and regulated frameworks. It means: in order to increase the country’s safety, central, territorial, later district and settlement-level voluntary rescue organisations and teams may be established. These units, considering their capabilities, are able to effectively and efficiently manage the impacts of anomalies due to the weather. In this publication, the author attempts to present Hungary’s vulnerability due to weather extremities with the help of the disaster management classification of settlements, to analyse the deployment possibilities of voluntary rescue organisations and rescue teams, taking into account their capabilities established in the framework of the national classification system.
The effect of creating knowledge according to the model (Nonaka & Takeuchi, 1995) on organizational ambidexterity: A study on a sample of Iraqi private banks
Authors: Ahmed Ahmed Hassan , Al-Kubaisi Salah Al-Din Awwad 
Published: May 2021

Purpose - This study relies on the descriptive and analytical approach through collecting and analyzing the necessary data, as this approach focuses on polling the opinions of the research sample and its directions, and aims to develop a model that studies the relationship between knowledge creation and organizational ambidexterity in Iraqi private banks and verifying its validity experimentally.
Design / Methodology / Introduction - A survey was conducted through a questionnaire form to collect data from a sample of (113) managers in private commercial banks. In addition, this study used the AMOS program and the ready-to-use statistical program package (SPSS V.25) to test the proposed hypotheses of the theoretical model experimentally.
Results - The results show that knowledge creation has a significant and positive indirect effect on stimulating organizational ambidexterity in private commercial banks through its effect on exploiting opportunities in the workplace and exploring opportunities in the external environment of banks.
Practical effects - to improve knowledge creation, bank management must pay more attention to it as a strategic resource to create wealth and added value to enable organizations to grow and survive through training courses, holders of higher degrees and attract knowledge expertise in addition to the need to maximize cultural awareness towards improving the organizational ambidexterity of banks, especially in Exploiting the bank's internal opportunities, both material and human, according to the current circumstances, through rewards moral and material incentives.

Originality / Value - This study complements and advances previous research on knowledge creation in several ways. First, the current study proposes a conceptual model that illustrates the interrelationships between the main variables in Iraqi private banks. Second, this study explores the role of organizational ambidexterity that benefits from exploiting and exploring opportunities in the context of knowledge acquisition, accumulation and exchange. Thus, overcoming the challenges associated with creating knowledge.
Desenvolvimento de cultivares de soja de crescimento indeterminado após a poda apical
Authors: Dias Gustavo Henrique de Oliveira , Lisboa Lucas Aparecido Manzani , Ferreira João Paulo Dal Santo , Rocha Edison Alves 
Published: May 2021

Algumas cultivares de soja de ciclo perene podem apresentar plasticidade na brotação dos ramos laterais, ou mesmo, pode ser estimulado após a sua poda apical em diferentes estádios fenológicos da cultura. Diante do exposto esse trabalho teve por objetivo avaliar o desenvolvimento de cultivares de soja de crescimento indeterminado após a poda apical. O experimento foi realizado em outubro de 2019, nas Faculdades Integradas Stella Maris (FISMA), localizada no Município de Andradina, Estado de São Paulo. O delineamento foi inteiramente casualizado, em esquema fatorial de 2x4, sendo dois cultivares de soja, DM81I84 IPRO e SYN 1687 IPRO, interagindo com a poda apical em quatro estádios diferentes de desenvolvimento, sendo eles: ausência de poda (controle), V4, V8 e R2, perfazendo oito tratamentos e com cinco repetições, totalizando 40 parcelas ou vasos. Não é recomendada a poda apical nas cultivares de soja DM81I84 IPRO e SYN 1687 IPRO. A poda apical na fase reprodutiva da soja influencia de maneira negativa a produtividade da cultura. A cultivar de soja DM81I84 IPRO se destacou nas características de produção. O número de galhos apresenta uma correlação positiva com a produtividade na cultura da soja.
Análise experimental comparativa entre concreto reciclado com agregado graúdo oriundo da reciclagem de resíduo de construção e demolição
Authors: Ponte Amanda Celestino , Ximenes Mariana Medeiros , Fernandes Sedna Karla Uchôa 
Published: May 2021

O setor da construção civil está cada vez mais em expansão em decorrência do crescimento demográfico; consequentemente, maior demanda por construção de habitações. Porém, têm-se percebido um aumento alarmante no volume de geração dos resíduos sólidos oriundos de construção e demolição (RCD). Diante disso, esse trabalho tem como objetivo principal utilizar resíduos gerados por perdas físicas em canteiros de obras para substituição parcial e total do agregado graúdo dos concretos convencionais e analisar sua eficiência para fins estruturais. Para isso foram realizados ensaios experimentais com substituição de agregado graúdo convencional por agregado constituído de resíduos de construção e demolição nos teores de 50% e 100%. Os resultados obtidos foram comparados com o do concreto convencional. A reutilização de RCD na fabricação dos concretos convencionais poderá trazer um manejo sustentável nas construções, visto que sua utilização pode gerar redução na exploração de recursos naturais, diminuição no volume de resíduo depositado no meio ambiente e redução na emissão de CO2, gerada pelas operações de transporte desse material até a destinação final. Portanto, buscou-se reunir dados/pesquisas com o propósito de apresentar como a viabilidade da confecção de concreto reciclado oriundo de resíduo de construção e demolição auxilia na busca por alternativas sustentáveis para deposição desses resíduos. Com os resultados obtidos foi possível observar que os concretos recicláveis apresentaram valores satisfatórios para seu uso na construção civil, desde que seja feito todo controle tecnológico para sua produção e execução, podendo ser utilizado para fins estruturais.
Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice
Authors: Demandt Jasper A. F. , van Kuijk Kim , Theelen Thomas L. , Marsch Elke , Heffron Sean P. , Fisher Edward A. , Carmeliet Peter , Biessen Erik A. L. , Sluimer Judith C. 
Published: May 2021

Background and aims: Atherosclerosis is an important cause of clinical cardiovascular events. Atherosclerotic plaques are hypoxic, and reoxygenation improves plaque phenotype. Central players in hypoxia are hypoxia inducible factors (HIF) and their regulators, HIF-prolyl hydroxylase (PHD) isoforms 1, 2, and 3. PHD inhibitors, targeting all three isoforms, are used to alleviate anemia in chronic kidney disease. Likewise, whole-body PHD1 and PHD2ko ameliorate hypercholesterolemia and atherogenesis. As the effect of whole-body PHD3 is unknown, we investigated the effects of germline whole-body PHD3ko on atherosclerosis.Approach and Results: To initiate hypercholesterolemia and atherosclerosis low-density lipoprotein receptor knockout (LDLrko) and PHD3/LDLr double knockout (PHD3dko), mice were fed a high-cholesterol diet. Atherosclerosis and hypoxia marker pimonidazole were analyzed in aortic roots and brachiocephalic arteries. In contrast to earlier reports on PHD1- and PHD2-deficient mice, a small elevation in the body weight and an increase in the plasma cholesterol and triglyceride levels were observed after 10 weeks of diet. Dyslipidemia might be explained by an increase in hepatic mRNA expression of Cyp7a1 and fatty acid synthase, while lipid efflux of PHD3dko macrophages was comparable to controls. Despite dyslipidemia, plaque size, hypoxia, and phenotype were not altered in the aortic root or in the brachiocephalic artery of PHD3dko mice. Additionally, PHD3dko mice showed enhanced blood hematocrit levels, but no changes in circulating, splenic or lymphoid immune cell subsets.Conclusion: Here, we report that whole-body PHD3dko instigated an unfavorable lipid profile and increased hematocrit, in contrast to other PHD isoforms, yet without altering atherosclerotic plaque development.
A Novel Graphene-Based Nanomaterial Modified Electrochemical Sensor for the Detection of Cardiac Troponin I
Authors: Li Jing , Zhang Shenwei , Zhang Li , Zhang Yu , Zhang Hua , Zhang Chuanxi , Xuan Xuexi , Wang Mingjie , Zhang Jinying , Yuan Yiqiang 
Published: May 2021

Acute myocardial infarction has a high clinical mortality rate. The initial exclusion or diagnosis is important for the timely treatment of patients with acute myocardial infarction. As a marker, cardiac troponin I (cTnI) has a high specificity, high sensitivity to myocardial injury and a long diagnostic window. Therefore, its diagnostic value is better than previous markers of myocardial injury. In this work, we propose a novel aptamer electrochemical sensor. This sensor consists of silver nanoparticles/MoS2/reduced graphene oxide. The combination of these three materials can provide a synergistic effect for the stable immobilization of aptamer. Our proposed aptamer electrochemical sensor can detect cTnl with high sensitivity. After optimizing the parameters, the sensor can provide linear detection of cTnl in the range of 0.3 pg/ml to 0.2 ng/ml. In addition, the sensor is resistant to multiple interferents including urea, glucose, myoglobin, dopamine and hemoglobin.
Development and Preliminary Analysis of a VLF-Band Electromagnetic-Wave Observation System for Short-Term Earthquake Precursory Monitoring
Authors: Nagao Toshiyasu , Kamogawa Masashi , Izutsu Jun , Suzuki Tomoyuki , Saito Airi , Sugiura Shigeki , Kondo Hitoshi 
Published: May 2021

Preseismic VLF electromagnetic pulses occasionally increase a few days before large earthquakes, especially inland earthquakes. More than two decades ago, the Tokai University group developed a digital recording system for collecting the preseismic electromagnetic pulse data and showed remarkable results. However, due to the limitations of personal computers’ data storage and CPU power during that time, they discontinued the observation. We relaunched this research using current technology. This paper shows the development of the new observation system and presents preliminary results. In addition, we introduce an electromagnetic-wave arrival discrimination algorithm that combines the autoregressive model and the Akaike information criterion, which are commonly used for automatic waveform reading in seismology, to obtain accurate data on the time of arrival (TOA) of electromagnetic waves. Then, source positioning was performed using TOA of electromagnetic waves. Seven electromagnetic pulses near the epicenter were observed 2 days before the largest inland earthquake (M = 5.6) that occurred near the observation network during the observation period (2016–2020). These VLF pulses may be a seismic precursory phenomenon because they were not electromagnetic pulses originating from lightning. These results encourage future observations.
GRK Inhibition Potentiates Glucagon-Like Peptide-1 Action
Authors: Lee Seunghun P. , Qi Jenson , Xu Guozhang , Rankin Matthew M. , Littrell James , Xu June Zhi , Bakaj Ivona , Pocai Alessandro 
Published: May 2021

The glucagon-like peptide-1 receptor (GLP-1R) is a G-protein-coupled receptor (GPCR) whose activation results in suppression of food intake and improvement of glucose metabolism. Several receptor interacting proteins regulate the signaling of GLP-1R such as G protein-coupled receptor kinases (GRK) and β-arrestins. Here we evaluated the physiological and pharmacological impact of GRK inhibition on GLP-1R activity leveraging small molecule inhibitors of GRK2 and GRK3. We demonstrated that inhibition of GRK: i) inhibited GLP-1-mediated β-arrestin recruitment, ii) enhanced GLP-1-induced insulin secretion in isolated islets and iii) has additive effect with dipeptidyl peptidase 4 in mediating suppression of glucose excursion in mice. These findings highlight the importance of GRK to modulate GLP-1R function in vitro and in vivo. GRK inhibition is a potential therapeutic approach to enhance endogenous and pharmacologically stimulated GLP-1R signaling.
CMR-Verified Myocardial Fibrosis Is Associated With Subclinical Diastolic Dysfunction in Primary Aldosteronism Patients
Authors: Zhou Fangli , Wu Tao , Wang Wei , Cheng Wei , Wan Shuang , Tian Haoming , Chen Tao , Sun Jiayu , Ren Yan 
Published: May 2021

ObjectivesThe main cardiac features of primary aldosteronism (PA) are impaired left ventricular (LV) diastolic function, and some articles also reported more cardiac fibrosis in PA patients. However, the correlation between LV dysfunction and diffuse myocardial fibrosis in PA remains unknown.MethodsWe enrolled 84 PA patients and 28 essential hypertension (EH) patients in West China Hospital. Cardiac magnetic resonance imaging (CMR) contrast enhancement was arranged for all subjects. Postcontrast T1 time and left ventricular myocardial strains and strain rates were measured.Results76 PA patients and 27 essential hypertension (EH) patients were included in the final analysis. Blood pressure, LV mass indexes, and LV ejection fractions were comparable in both groups, while the global circumferential peak diastolic strain rate (PDSR) was lower (0.9 ± 0.3 vs. 1.1 ± 0.4, p &lt;0.01) and the postcontrast T1 time was shorter (520 ± 38 vs. 538 ± 27, p = 0.01) in PA patients than those in EH patients. Postcontrast T1 time (p = 0.01) was independently related to global circumferential PDSR after adjusting for age and duration of hypertension in PA patients. Furthermore, plasma aldosterone concentration was negatively associated with postcontrast T1 time (R = −0.253, p = 0.028) in PA patients.ConclusionsThe global circumferential PDSR derived by CMR is decreased, and the diffuse myocardial fibrosis is increased in PA patients compared to those in blood pressure matched EH patients. The severity of cardiac diastolic dysfunction independently relates to the degree of diffuse myocardial fibrosis in PA patients, and the diffuse myocardial fibrosis may be caused by high PAC level.Clinical Trial Registrationhttp://www.chictr.org.cn/listbycreater.asp, identifier ChiCTR2000031792.