bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiomyofibroblastoma férfiban – egy ritka paratesticularis eltérés és irodalmi áttekintés
Authors: Kakuja Flóra , Palásti Péter , Oroszi Márton , Kuthi Levente , Király István Előd , Kincses Zsigmond Tamás , Palkó András , Fejes Zsuzsanna 
Published: August 2021

Összefoglaló. A scrotum képalkotó vizsgálóeljárásai közül elsőnek
választandó az ultrahang, mivel könnyen hozzáférhető, szenzitivitása és
specificitása magas. Szerepe kiemelendő mind az intratesticularis eltérések
differenciáldiagnózisában, mind pedig a kevésbé ismert paratesticularis
eltérések esetében. Az urológiai ambulancián egy 56 éves férfi jelentkezett
kivizsgálásra tapintható terime miatt. Ultrahangvizsgálattal paratesticularis
elváltozás látszódott, mely a vizsgálat során az inguinalis csatorna irányába
többször elmozdult. A laesio dignitása nem volt meghatározható, ezért műtéti
eltávolításra került sor. A szövettani vizsgálat a férfiak körében ritkán
előforduló angiomyofibroblastoma diagnózisát véleményezte. A paratesticularis
elváltozások ugyan ritkán fordulnak elő, de a gyakoribb entitások és azok
ultrahangos sajátosságainak ismerete elengedhetetlen a terápia tervezése
szempontjából. Orv Hetil. 2021; 162(34): 1376–1382.
Summary. Ultrasonography is the basic imaging technique for the
evaluation of testicular structures because it is easily accessible and has high
sensitivity and specificity. It plays a significant role in the differential
diagnosis of intratesticular changes, in addition, its role should be emphasised
in rare paratesticular abnormalities. A 56-year-old male presented in the
urology department complaining of a palpable inguinal mass and was referred to
ultrasonography for further evaluation. A scrotal ultrasound was performed, and
it described a mobile paratesticular mass without any specific
characterizations. Therefore the lesion was removed, and the histological
analysis established the diagnosis of angiomyofibroblastoma. Paratesticular
lesions are rare, but it is essential to know the frequent abnormalities and the
corresponding ultrasound findings for planning of treatment. Orv Hetil. 2021;
162(34): 1376–1382.
Dializált betegek életviteli nehézségeinek megismerése kvantitatív vizsgálómódszerekkel
Authors: Mátyás Eszter , Hargitai Rita , Haris Ágnes 
Published: August 2021

Összefoglaló.
Bevezetés: A krónikus vesebetegség tünetei, a kezelés
sajátosságai nagymértékben korlátozzák a páciensek mindennapi életvitelét,
hatással vannak testi és lelki egészségükre, és nehezítik társas kapcsolataikat.
Célkitűzések: A jelen kutatás célja a magyar dializált
betegpopuláció egészségműveltségének, életminőségének és betegségterhének
megismerése, továbbá a kezelési típusok hatását kívántuk felmérni a fent
említett pszichológiai tényezők mentén. Módszer: A vizsgálatban
42 krónikus dializált személy vett részt: 31 hemodializált és 11 hasi dialízist
végző vesebeteg. Átlagéletkoruk 63,33 ± 12,92 év. A minta életkor, nemi eloszlás
és családi állapot alapján reprezentatív. Kérdőíves technikával mértük a betegek
életminőségét, egészségműveltségét és betegségterhét.
Eredmények: Eredményeink szerint a peritonealis dialízist
végző betegek szignifikánsan magasabb egészségműveltséggel rendelkeznek, mint
hemodializált betegtársaik. Ez a jelentős különbség az életminőségük több
területén is kimutatható volt. Következtetés: Eredményeink a
betegedukáció és a kezelőszemélyzettől kapott támogatás (bátorítás)
jelentőségére hívják fel a figyelmet. A betegoktatás a hemodializált
betegcsoport esetében is kiemelten fontos. A klinikai szempontból hasznos
intervenciós javaslatokat fogalmaztunk meg, melyek célzottan az
egészségműveltség fejlesztésére irányulnak. Orv Hetil. 2021; 162(30):
1208–1215.
Summary.
Introduction: The symptoms of chronic kidney disease, the
peculiarities of the treatment greatly limit the patients’ daily life, affect
their physical and mental health and make their social relationships more
difficult. Objective: The purpose of this research is to
explore the health literacy, the health-related quality of life and illness
intrusiveness of Hungarian dialysis patients. Furthermore, we wanted to assess
the effect of treatment types along the psychological factors mentioned above.
Method: The sample consisted of 42 patients with chronic
kidney disease, 31 of whom have hemodialysis and 11 have peritoneal dialysis
treatment. Their mean age was 63.33 ±12.92 years. The sample is representative
by age, gender, and marital status. We measured the health-related quality of
life, the health literacy and illness intrusiveness of the patients using
special questionnaire techniques. Results: The peritoneal
dialysis patients have significantly higher health literacy than their
hemodialysis counterparts. This significant difference was seen in several areas
of their quality of life as well. Conclusion: Our results draw
attention to the importance of patient education and the special support by the
treatment staff. The patient education for the haemodialysis group is of
paramount importance for the hemodialysis group, too. We have formulated
clinically useful intervention proposals aimed at improving health literacy. Orv
Hetil. 2021; 162(30): 1208–1215.
Hol van a normális és a kóros vérnyomás közötti határ, és mi a terápiás cél a cardiovascularis és a renalis betegségekben?
Authors: Kékes Ede , Nagy Judit , Vályi Péter 
Published: August 2021

Összefoglaló. Az irodalmi adatok arra utalnak, hogy a systolés
vérnyomás értékének emelkedése már 110–115 Hgmm-től együtt jár az
atherosclerosissal összefüggő elváltozások kialakulásával is és ezzel együtt a
cardiovascularis és a renalis funkció romlásával. Az összefüggés exponenciális,
de mértékét az életkor jelentősen befolyásolja. A kezelés során az elérendő
vérnyomás célértéke a jelenlegi adatok alapján 120–130 Hgmm között helyezkedik
el a 18–65 év közötti populációban; idősebb korban – különösen 80 év felett –
ennél magasabb, a 130 Hgmm alatti érték elérése nem reális, de talán nem is
szükséges. A leghelyesebb az egyéni vérnyomásprofil meghatározása, és számos
befolyásoló tényezőt is figyelembe kell venni a páciens legmegfelelőbb
kezeléséhez. A populáció egészségének javításához és megőrzéséhez az egyik
legfontosabb és leggyakoribb cardiovascularis kockázati tényezőt, a magas
vérnyomást időben fel kell fedezni, amihez a vérnyomást rendszeresen szükséges
ellenőrizni, és ezzel párhuzamosan kell végezni a prevenciót célzó
tevékenységeket (nevelés, oktatás, szűrés, egészségtudatos életmód) is. Orv
Hetil. 2021; 162(34): 1351–1361.
Summary. The data in the literature suggest that the increase in the
value of systolic blood pressure from 110–115 mmHg leads to the development of
atherosclerotic process and to the deterioration of cardiovascular and renal
function. The correlation is initially linear, then above 140–150 mmHg it is
already exponential, but it is also related to the progression of the age. The
systolic target for therapy is between 120–130 mmHg in the population aged
18–65; in older ages – especially over 80 years – it is higher and reaching the
value below 130 mmHg is unrealistic, and may even be not necessary. It is the
best to determine the individual treatment, taking into account the individual
blood pressure profile and the factors influencing the patient. In order to
improve and maintain the health of the population – in addition to unknown
hypertension – it is necessary to regularly monitor blood pressure and apply the
known preventive methods (education, training, screening, etc). Orv Hetil. 2021;
162(34): 1351–1361.
A tüdő immunfiziológiája – útjelzők a terra incognita felé
Authors: Balogh Péter 
Published: August 2021

Összefoglaló. A tüdő a benne lévő légutak és a légzőhám felületének
kiterjedtsége, valamint a folyamatos napi gázcsere mennyisége miatt az
emlősszervezetnek a környezeti antigének számára legnagyobb mértékben kitett
közvetlen behatolási kapuja. A különböző antigénekkel szemben számos
fizikai-mechanikai tisztulási folyamat, valamint helyi és szisztémás
immunológiai védelmi mechanizmus együttesen biztosítja a légutak átjárhatóságát
és a megfelelő gázcseréhez a légzőhám és a tüdő interstitialis összetevőinek
szöveti integritását. A tüdő – veleszületett és adaptív immunológiai – védelmét
ellátó molekuláris és sejtes résztvevőkre, ezáltal a légutak alapvető
életfontosságú működésének biztosítására vonatkozó ismereteink az utóbbi időben
számos új megfigyeléssel bővültek, melyek felvetik a tüdő immunológiai
szerveződésének egyedi szerkezeti és funkcionális specializációját. A jelen
összefoglaló célja ezeknek az új eredményeknek a bemutatása, ezen keresztül a
tüdőben zajló sokrétű immunológiai folyamatok főbb jellemzőinek és a bennük
részt vevő sejtes és molekuláris összetevőknek az áttekintése. Ezek részletesebb
megismerése elősegítheti a légúti (köztük a SARS-CoV-2 általi) fertőzések után
fellépő, helyi és szisztémás immunpatológiai események pontosabb megértését és a
lehetséges terápiás eljárások kritikai értelmezését. Orv Hetil. 2021; 162(29):
1147–1155.
Summary. Due to the size of the surface area of airways and
respiratory epithelium combined with the daily amount of continuous gas
exchange, in mammalians the lung represents the most exposed organ serving as
immediate entry port for airborne antigens. Together with several
physicochemical clearance processes, both local and systemic immunological
defense mechanisms ensure the passage of airways and the tissue integrity of
respiratory epithelium and pulmonary interstitium necessary for the maintenance
of gas exchange. Several recent observations concerning the molecular and
cellular constituents of the pulmonary immunological defense have substantially
broadened our knowledge of the maintenance of the vital functionality of
airways, raising the unique specialization of the organization of pulmonary
immune compartment. The purpose of the present review is to highlight the main
findings on the complexity of pulmonary immunity, including the overview of the
main characteristics of its cellular and molecular participants. Unrevealing
these mechanisms may promote our understanding the local and systemic
immunopathological processes occurring after airway infections (including
SARS-CoV-2) and the critical assessment of potential therapeutic interventions.
Orv Hetil. 2021; 162(29): 1147–1155.
Posztakut COVID–19 szindróma
Authors: Szekanecz Zoltán , Vályi-Nagy István 
Published: August 2021

Összefoglaló. A posztakut COVID–19 szindróma (PACS) az akut
betegséget követő 4–12 hét szubakut, tünetes szakasznak, valamint az ezt követő
krónikus poszt-COVID-időszaknak az együttesét jelenti. A PACS különböző
általános tünetekkel és szervi (pulmonalis, cardiovascularis,
neuropszichiátriai, endokrin, mozgásszervi, bőrgyógyászati, renalis)
manifesztációkkal jár. Ebben az összefoglalóban áttekintjük a PACS
kialakulásához vezető patogenetikai és rizikótényezőket. Bemutatjuk a klinikumot
és a diagnosztikát. A PACS ellátása alapvetően háziorvosi feladat, mely a szervi
tünetek gyógyszeres és nem gyógyszeres kezeléséből, multidiszciplináris
rehabilitációból és gondozásból áll. Kitérünk a háziorvos feladataira, a
szakellátásba történő beutalás indokaira és a poszt-COVID-hálózat létrehozásának
és működtetésének szükségességére is. Orv Hetil. 2021; 162(27): 1067–1078.
Summary. Post-acute COVID-19 syndrome (PACS) includes the subacute,
symptomatic phase 4–12 weeks after acute COVID-19 as well as the subsequent
chronic post-COVID-19 period. PACS is associated with various general symptoms
and organ (pulmonary, cardiovascular, neuropsychiatric, endocrine,
musculoskeletal, dermatological, renal) manifestations. In this summary, we
review the pathogenetic and risk factors leading to the development of PACS. We
present the clinical picture and diagnostics. PACS should usually be managed by
the general practitioner. The management of PACS includes pharmacological and
non-pharmacological treatment, multidisciplinary rehabilitation and regular
follow-ups. Here we also discuss the tasks of the general practitioner, the
reasons for referral to specialists and the need to set up and operate a
post-COVID-19 network. Orv Hetil. 2021; 162(27): 1067–1078.
Inhibiting Focal Adhesion Kinase Ameliorates Cyst Development in Polycystin-1–Deficient Polycystic Kidney Disease in Animal Model
Authors: He Jinzhao , Zhang Shun , Qiu Zhiwei , Li Xiaowei , Huang Huihui , Jin William , Xu Yue , Shao Guangying , Wang Liang , Meng Jia , Wang Shuyuan , Geng Xiaoqiang , Jia Yingli , Li Min , Yang Baoxue , Jenny Lu Hua A. , Zhou Hong 
Published: August 2021

Significance Statement
Focal adhesion kinase (FAK) has been widely studied and shown to have a crucial effect on tumor progression. Although autosomal dominant polycystic kidney disease (ADPKD) shares numerous commonalities with tumors, it is undetermined whether FAK is involved in cyst development. Our study demonstrates that inhibiting FAK activity using small molecule FAK inhibitor VS-4718 ameliorates ADPKD progression and improves renal function. Inhibiting FAK and its downstream Src signaling suppresses cAMP-mediated aberrant proliferation of cystic epithelial cells in ADPKD animals. This study highlights the therapeutic potential of small molecule FAK inhibitors in treating patients with ADPKD.

Background
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by numerous cysts originating from renal tubules and is associated with significant tubular epithelial cell proliferation. Focal adhesion kinase (FAK) promotes tumor growth by regulating multiple proliferative pathways.

Methods
We established the forskolin (FSK)-induced three-dimensional (3D) Madin–Darby Canine Kidney cystogenesis model and 8-bromoadenosine-3`,5`-cyclic monophosphate–stimulated cyst formation in ex vivo embryonic kidney culture. Cultured human renal cyst–lining cells (OX-161) and normal tubular epithelial cells were treated with FAK inhibitors or transfected with green fluorescent protein–tagged FAK mutant plasmids for proliferation study. Furthermore, we examined the role of FAK in two transgenic ADPKD animal models, the kidney-specific Pkd1 knockout and the collecting duct–specific Pkd1 knockout mouse models.

Results
FAK activity was significantly elevated in OX-161 cells and in two ADPKD mouse models. Inhibiting FAK activity reduced cell proliferation in OX-161 cells and prevented cyst growth in ex vivo and 3D cyst models. In tissue-specific Pkd1 knockout mouse models, FAK inhibitors retarded cyst development and mitigated renal function decline. Mechanically, FSK stimulated FAK activation in tubular epithelial cells, which was blocked by a protein kinase A (PKA) inhibitor. Inhibition of FAK activation by inhibitors or transfected cells with mutant FAK constructs interrupted FSK-mediated Src activation and upregulation of ERK and mTOR pathways.

Conclusions
Our study demonstrates the critical involvement of FAK in renal cyst development, suggests that FAK is a potential therapeutic target in treating patients with ADPKD, and highlights the role of FAK in cAMP-PKA–regulated proliferation.
EVALUATION OF THE ØREBLUE® METHOD IN THE TREATMENT OF TINNITUS AND HYPERACUSIS: RESULTS OF A MONOCENTRIC OBSERVATIONAL EFFECTIVENESS STUDY IN 74 PATIENTS
Authors: CHETRITT-BONNEYRAT Natacha , BIANCO Erkki 
Published: August 2021

BackgroundØreblue® is a new treatment method for tinnitus and hyperacusis combining auditive rehabilitation and psychological therapy. The present monocentric observational retrospective study was to assess patient’s judgements of its effectiveness.Material and methodsFrom January 2011 to June 2015, 74 consecutive healthy patients (male/female, 51/23; median age, 51.5 years) with chronic tinnitus (without hyperacusis, 32) or hyperacusis (with tinnitus, 42) were treated according to priority at the Hearing Institute of Resources (La Rochelle, France). They were asked to rank their discomfort, quality of life, and sleep quality before and 1 month after treatment using 10-point scales ranging from 0 (no discomfort, poor quality of life, or poor sleep quality) to 10 (unbearable discomfort, best quality of life, or best sleep quality) and their global impression of change on a 10-point scale ranging from 0% (not improved) to 100% (fully improved). These data which were reported in patient medical files were retrospectively analysed in 2018.ResultsDiscomfort, which was severe at inclusion (8.9±0.8), drastically decreased after treatment (change: 8.5±1.3). Quality of life and sleep improved (from 2.2±1.4 and 2.0±1.9 to 8.3±1.4 and 4.9±2.1, respectively). 81.3% of the patients with tinnitus and 100% of patients with hyperacusis claimed to be fully improved. No adverse events were reported during the study.ConclusionsThe Øreblue® method was effective on discomfort related to tinnitus or hyperacusis; it greatly improved quality of life and sleep. Further studies, especially multicentric or randomised, possibly with imaging and long-term follow-up, should be performed to strengthen these encouraging findings.
THE EFFECTS OF EMPLOYMENT AND FINANCIAL EMPOWERMENT OF WOMEN ON DOMESTIC VIOLENCE: THE CASE OF TURKEY
Authors: ALGÜL Yahya , YARBAŞI İkram Yusuf 
Published: August 2021

As one of the fastest developing countries in the world, Turkey has been suffering from
domestic violence significantly in recent decades and it has been one of the hottest topics discussed
both in public and in the national media. On the other hand, it is interesting that according to United
Nations Turkey is one of the leading countries in the MENA regarding the fight against domestic
violence and supporting women’s legal rights in general. However, beyond the legal rights and state
support to women, together with other socioeconomic factors, employment status and financial
empowerment of women may be linked to sexual and physical violence against women. In this study,
it is aimed to investigate this potential relationship by using the “Research on Domestic Violence
Against Women in Turkey” survey data conducted by the Turkish Statistical Institute in 2014. The
multinomial probit model was used to modeling the effects of employment and financial
empowerment on violence against women. According to estimations results, women who have a job
may less likely to experience some types of domestic violence.
INOVAÇÃO DE VALOR E USO DE UMA PLATAFORMA DE IDEIAS POR UMA UNIVERSIDADE BRASILEIRA | VALUE INNOVATION USING AN IDEA PLATFORM AT A BRAZILIAN UNIVERSITY
Authors: Martins Teresa Cristina Monteiro , Zambalde André Luiz 
Published: August 2021

Nos últimos anos, instituições públicas de diversos países adoram iniciativas inovação aberta, sobretudo desafios de ideias, visando maior colaboração dos cidadãos na gestão pública. Entretanto, percebe-se a ausência de aprofundamento envolvendo valores e inovação efetivamente agregados por estas iniciativas às organizações e cidadãos. Na presente pesquisa, busca-se discutir e aprofundar investigações neste contexto, utilizando-se o “radar da inovação de valor”: um modelo teórico, proposto por Martins et al. (2019), composto por quatro dimensões e doze fatores críticos para a percepção de inovação em projetos do setor público. Tem-se como objetivo principal aplicar o modelo radar a um desafio de ideias, denominado “Desafio Uni+”, promovido por uma universidade pública brasileira. Trata-se de uma pesquisa aplicada, com objetivos de caráter exploratório-descritivo, abordagens quantitativa e qualitativa e tendo como unidade de análise o “Desafio Uni+”. Como resultados têm-se a análise e a discussão da adequabilidade estatística dos fatores do radar, além da descrição da percepção de inovação de valor associada à participação no “Desafio Uni+”. Conclui-se que o fator Colaboração não atende à adequabilidade estatística e não pode ser considerado para avaliar o projeto Uni+. E que a comunidade acadêmica percebeu o projeto como inovador em relação à abertura e à eficiência para captação de ideias, entretanto, não percebeu, ou não foi adequadamente informada, sobre a geração de valor e implementação das ideias vencedoras do processo. DOI: 10.18226/23190639.v9n1.07 Teresa Cristina Monteiro Martins, UFLA, Brasil, Email: teresacristina.ufla@gmail.comAndré Luiz Zambalde, UFLA, Brasil, Email: zamba@ufla.br Submetido: Agosto, 2020Aceito: Agosto, 2021*Contato para Correspondência
Standardization of Different Pre-sowing Seed Treatments on Growth, Yield and Yield Attributing Traits of Kodo Millet (Paspalum scorbiculatum)
Authors: Kavitha Maddipoti , Rai Prashant Kumar , Haritha B. , Kumar R. Karthik , Kumar A. Hemanth , Khandka Sarita 
Published: August 2021

Background: Paspalum scorbiculatum is an annual crop and has superior nutritional properties including high micronutrients, dietary fiber content and gluten free. It has low glycemic index (GI) carbohydrate diets help in prevention of Obesity, Diabeties and Cardiovascular diseases, etc. The current study was aimed to find out the suitable pre- sowing seed treatments for Kodo millet. Methods: During the Kharif season 2019- 2020 total of 12 pre- sowing seed treatments were subjected with Botanicals, Magnetic and Electric fields, Thermal (Hot water) treatments and to fix the best treatment based on Seed Quality and Morphological traits of treated seeds. Morphological traits play an major role in crop growth and development where as, the present investigation was carried out with farmer’s variety in field (RBD) design in 3 replications and laboratory (CRD) design in 4 replications in order to “Standardization of different pre- sowing seed treatments on growth, yield and yield attributing traits of Kodo millet (Paspalum scorbiculatum). Seeds were subjected to various pre- sowing seed treatments viz. (T0) control, exposure to Magnetic field at 100 mT, 200 mT, 400 mT for 15,30 and 45 min; exposure to Electric field at 50 mA, 100 mA, 150 mA for 5,10, 15 min. Treatment with botanicals cow dung (5 gm) and Datura leaf extract (2.5 ml) for 12 hrs; Thermal hot water treatment at 46°C and 50°C for 10 min. Result: Among all the treatments, T4-Magnetic field (200 mT) gave the best results in field and lab conditions of field emergence (98.610) and germination% (98.5), Magnetic field (400 mT) shown the good results and significantly higher values of all other yield (45.867, 78.833, 660.480, 165.120) and morphological traits as well as seed quality parameters like shoot length (86.925), root length (44.55), seedling length (13.131), vigour index- I and II (1267.138 and 5.058), fresh (0.343) and dry (0.0524) weight of seedlings and comparatively control (T0) was observed lowest to other treatments. As such, Magnetic treatment is quite effective for seedling establishment to overcome low germination and yield which helps in Qualitative and Quantiative seed production of Millets in sustainable agriculture.