bluuebunny/crossref_metadata_2025_split huggingface dataset:
Τhe association of heart failure across left ventricular ejection fraction with mortality in atrial fibrillation
Authors: Kartas Anastasios , Samaras Athanasios , Akrivos Evangelos , Vrana Eleni , Papazoglou Andreas S. , Moysidis Dimitrios V. , Papanastasiou Anastasios , Baroutidou Amalia , Botis Michail , Liampas Evangelos , Vouloagkas Ioannis , Karagiannidis Efstratios , Karvounis Haralambos , Parissis John , Tzikas Apostolos , Giannakoulas George 
Published: June 2021

AbstractAimsThe aim of this study is to investigate the prognostic implications of the presence of heart failure (HF) across the range of left ventricular ejection fraction (LVEF) in patients with comorbid atrial fibrillation (AF).Methods and resultsWe conducted a retrospective cohort study of 1063 patients (median age 76 years), discharged from the cardiology ward with a primary or secondary diagnosis of AF between 2015 and 2018. We used Cox proportional‐hazards and spline models to examine the association of the presence of HF, across the range of LVEF, with the primary outcome of all‐cause mortality. HF was documented in 52.9% of patients at baseline. During a median follow‐up of 31 months (interquartile range 10 to 52 months), 37.3% of patients died. The presence of HF was associated with a significantly higher risk of mortality [adjusted hazard ratio (aHR) 2.17; 95% confidence interval (CI), 1.70 to 2.77; P < 0.001], which was evident across HF with reduced (aHR 3.03; 95% CI 2.41 to 4.52), mid‐range (aHR 2.08; 95% CI 1.47 to 2.94), and preserved LVEF (aHR 1.94; 95% CI 1.47 to 2.55). Among patients with HF, the spline curve depicted a non‐linear association between LVEF and the risk of death, in which there was a steep and progressive increase in mortality for every 5% reduction in LVEF below 25% (aHR 1.97, 95% CI 1.04 to 3.73, P = 0.04).ConclusionsIn patients with AF who were discharged from the hospital, the presence of HF at baseline was independently associated with a twofold risk of death, which was significant across LVEF‐classified HF subtypes. Among patients with AF and HF, the risk of death rose significantly as LVEF was reduced below 25%.
Identification of the predominant human NK cell effector subset mediating ADCC against HIV‐infected targets coated with BNAbs or plasma from PLWH
Authors: Tomescu Costin , Kroll Kyle , Colon Krystal , Papasavvas Emmanouil , Frank Ian , Tebas Pablo , Mounzer Karam , Reeves Roger Keith , Montaner Luis J. 
Published: June 2021

AbstractThe potential of immunotherapy strategies utilizing broadly neutralizing antibodies (BNAbs), such as 3BNC117 and 10‐1074, to limit viral replication while also facilitating clearance of HIV infected cells has heightened interest in identifying the predominant NK effector subset(s) capable of mediating antibody dependent cellular cytotoxicity (ADCC). Utilizing advanced polychromatic flow cytometry, we identified that CD57 positive NK cells from ART‐suppressed in People Living With HIV (PLWH) expressed significantly higher levels of the CD16 FcγR receptor, 2B4 ADCC coreceptor, and HLA‐DR activation marker while NKG2C positive NK cells expressed significantly higher levels of the CD2 ADCC coreceptor (p < 0.001, n = 32). Functionally, CD57 positive NK cells from ART‐suppressed PLWH with either high or low NKG2C expansion exhibited significantly enhanced degranulation and IFN‐γ production against heterologous gp120‐coated ADCC targets coated with HIV reference plasma compared to CD57 negative NK cells (p = 0.0029, n = 11). CD57 positive NK cells from control donors lacking NKG2C expansion also exhibited significantly more degranulation and IFN‐γ production at every timepoint tested against both heterologous ADCC targets (p = 0.019, n = 9) and HIV‐1 infected autologous CD4+ primary T cells coated with BNAbs. Together, our data support CD57 positive and NKG2C positive NK cells as the predominant ADCC effector subsets capable of targeting HIV‐infected CD4+ cells in the presence of 3BNC117 and 10‐1074 immunotherapy.
Generation of Catalytically Active Gold Nanocrystals in Water Induced with Ferrocene Carboxylate
Authors: Wang Changlong , Brudo Agathe , Ducrot Laurine , Fu Fangyu , Ruiz Jaime , Escobar Ane , Martinez‐Villacorta Angel , Moya Sergio , Astruc Didier 
Published: June 2021

AbstractThe fabrication and properties of anisotropic gold nanoparticles (AuNPs) are of great interest from fundamental and application standpoints. Whereas various neutral ferrocene derivatives have been shown to reduce AuIII to Au0NPs owing to slightly exergonic electron transfer in biphasic systems, the question remained open for water soluble ferrocenes containing electron withdrawing substituents increasing the FeIII/FeII oxidation potential. Here, it is shown that reaction of sodium ferrocene carboxylate, NaFcCO2, alone, does not reduce H[AuIIICl4] to stable AuNPs under ambient conditions in water. On the other hand, reaction between NaFcCO2 and H[AuIIICl4] in water in the presence of poly (vinyl pyrrolidone) (PVP), citrate or other 1,2,3‐triazole (trz)‐containing stabilizers is shown to produce catalytically active Au nanocrystals with various shapes. EDX results confirm the fixation of the ferrocenyl carboxylate ligand onto the AuNP surface. 4‐nitrophenol reduction to 4‐aminophenol by Na[BH4] in water proceeds in the presence of the various stabilizers, without induction time in most cases, which confirms the weakness of the ferrocenyl carboxylate ligand bonded to the AuNP surface and the favorable role of ferrocenyl carboxylate ligand for catalysis at the AuNP surface.
Crystal Structures of Tetramesityl‐Substituted Tetracyclopenta[def,jkl,pqr,vwx]tetraphenylene
Authors: Miyoshi Hirokazu , Hisaki Ichiro , Tobe Yoshito 
Published: June 2021

AbstractCrystal structures of tetramesityl‐substituted tetracyclopenta[def,jkl,pqr,vwx]tetraphenylene (TCPTP) derivative were determined for crystals containing different solvents, CHCl3, CH2Cl2, acetone, and benzene at different temperatures to discuss the conjugation modes in the antiaromatic system, i. e., whether it adopts a D2h structure consisting of local aromatic sextets and quinodimethane substructures or a D4h double annulenenoid structure. The structures of the TCPTP core in all crystals determined at 113 K or 93 K resemble those of the theoretical D2h geometry, whereas the bond lengths at room temperature (293 K) adopt averaged values of the theoretical D2h and D4h geometries. These results are interpreted in terms of disorder of two perpendicularly oriented D2h structures at room temperature and support the theoretical prediction which favours the D2h geometry. The slightly different bond length distributions in the crystals are ascribed to the different space in the vicinity of the molecule which allows the molecule to adopt the two orientations in different occupancies.
Nickel‐Catalyzed Asymmetric Hydrogenation of Hydrazones
Authors: Li Bowen , Liu Dan , Hu Yanhua , Chen Jianzhong , Zhang Zhenfeng , Zhang Wanbin 
Published: June 2021

AbstractAn efficient nickel‐catalyzed asymmetric hydrogenation of hydrazones to chiral hydrazines has been realized with up to 99 % yield and 99.4 : 0.6 er. Deuterium labelling experiments indicated that the hydrazone substrates undergo imine‐enamine tautomerization in the mixed solvents. Studies on the effects of acids revealed that the required acid assistance promoted the dissociation of the active nickel catalyst in the catalytic cycle.
Recent advances in microbial capture of hydrogen sulfide from sour gas via sulfur‐oxidizing bacteria
Authors: Chen Zheng , Yang Gama , Hao Xuemi , Samak Nadia A. , Jia Yunpu , Peh Sumit , Mu Tingzhen , Yang Maohua , Xing Jianmin 
Published: June 2021

AbstractBiological desulfurization offers several remarkably environmental advantages of operation at ambient temperature and atmospheric pressure, no demand of toxic chemicals as well as the formation of biologically re‐usable sulfur (S0), which has attracted increasing attention compared to conventionally physicochemical approaches in removing hydrogen sulfide from sour gas. However, the low biomass of SOB, the acidification of process solution, the recovery of SOB, and the selectivity of bio‐S0 limit its industrial application. Therefore, more efforts should be made in the improvement of the BDS process for its industrial application via different research perspectives. This review summarized the recent research advances in the microbial capture of hydrogen sulfide from sour gas based on strain modification, absorption enhancement, and bioreactor modification. Several efficient solutions to limitations for the BDS process were proposed, which paved the way for the future development of BDS industrialization.
A new optimization technique to solve the latency aware controller placement problem in software defined networks
Authors: Dhar Mili , Bhattacharyya Bidyut K. , Kanti Debbarma Mrinal , Debbarma Swapan 
Published: June 2021

AbstractSoftware defined networking (SDN) is a modern and upcoming standard in today's network as it centralizes the network intelligence by separating the control plane from the forwarding plane. Placing a controller in an appropriate location and minimizing the switch to controller (SC) latency are important factors in SDN. In this article, we proposed a mathematical algorithm to form the clusters and placed one controller in each cluster to shorten the worst‐case SC latency. We have proposed a technique called the “$‐method” by using the distance matrix of the network nodes and placed a “$” whenever we have found the matrix element is greater than a given maximum distance. Initially, the maximum distance is calculated using the center of mass method that we have developed for minimizing the average SC latency. Our method guarantees that it will generate the minimum worst‐case SC latency efficiently that one could ever achieve for a different number of controller placement. Simulation has been done under some real‐world network topologies from the dataset of Internet Topology Zoo. Our result shows that the “$‐method” performs better compared with other existing algorithms in terms of worst‐case SC latency minimization with less number of controllers. Further, we have analyzed our method for the failure mode of a controller by assigning the switches of that failed controller to its nearest controllers which shows that our method also performs better in terms of network fault tolerance and improves network resilience.
Effect of slurry ice during storage on myofibrillar protein of Pseudosciaena crocea
Authors: Guan Feng , Chen Yirui , Zhao Simin , Chen Zhuo , Yu Chen , Yuan Yongjun 
Published: June 2021

AbstractIn order to explore the effect of slurry ice on myofibrillar protein of Pseudosciaena crocea, the changes in myofibrillar protein and muscle microstructure during storage were studied with crushed ice as a control. During the storage period, the rate of decrease in myofibrillar protein content, Ca2+‐ATPase activity, and total sulfhydryl groups in the slurry ice group was lower than in the control group (p < .05). There was a significant linear correlation between the hydrophobicity and the storage time (Rcrushed ice (4℃) = 0.9881, Rslurry ice (4℃) = 0.9878, Rslurry ice (−1℃) = 0.9674), and trichloroacetic acid (TCA) soluble peptide content was lower than in the control group at the same time. Slurry ice (−1℃) was optimal in maintaining protein content in P. crocea; the arrangement of myofibrils in P. crocea treated by slurry ice was compact and the gaps were small. Slurry ice can delay the denaturation and degradation of fish myofibrillar protein and maintain its quality.
Study on relationship between bacterial diversity and quality of Huangjiu (Chinese Rice Wine) fermentation
Authors: Xie Guangfa , Zheng Huajun , Qiu Zheling , Lin Zichen , Peng Qi , Dula Bealu Girma , Elsheery Nabil Ibrahim , Lu Yin , Shen Chi , Fu Jianwei , Yang Huanyi , Han Jiongping , Lu Jian , Liu Guanming 
Published: June 2021

AbstractHuangjiu (Chinese rice wine) is brewed in an open environment, where bacteria play an important role during the fermentation process. In this study, bacterial community structure and composition changes in the fermented mash liquid of mechanized Huangjiu, well‐fermented manual Huangjiu (wines of good qualities), and poorly fermented manual Huangjiu (wines of poor qualities: spoilage, high acidity, low alcohol content) in different fermentation stages from Guyuelongshan Shaoxing Huangjiu company were analyzed via metagenomic sequencing. And bacterial metabolic difference was analyzed via gene prediction of metabolic pathway enzymes. The results showed that the bacterial diversity degree was abundant, and the number of bacterial species in every sample was approximately 200–400. Lactic acid bacteria (LAB) dominated the bacterial community of Huangjiu fermentation, and lactobacillus was predominant species in well‐fermented Huangjiu while Lactobacillus brevis had an absolute dominance in spoilage Huangjiu. Further, gene prediction revealed that transformation of malate to pyruvate and lactate anabolism was more active in mash liquid of well‐fermented manual Huangjiu, while acetate accumulation was stronger in mash liquid of poorly fermented manual Huangjiu, which explained acidity excess reason in poorly fermented Huangjiu at gene level.
Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study
Authors: Bauer Alina , Zierer Astrid , Gieger Christian , Büyüközkan Mustafa , Müller‐Nurasyid Martina , Grallert Harald , Meisinger Christa , Strauch Konstantin , Prokisch Holger , Roden Michael , Peters Annette , Krumsiek Jan , Herder Christian , Koenig Wolfgang , Thorand Barbara , Huth Cornelia 
Published: June 2021

AbstractIt is still unclear how genetic information, provided as single‐nucleotide polymorphisms (SNPs), can be most effectively integrated into risk prediction models for coronary heart disease (CHD) to add significant predictive value beyond clinical risk models. For the present study, a population‐based case‐cohort was used as a trainingset (451 incident cases, 1488 noncases) and an independent cohort as testset (160 incident cases, 2749 noncases). The following strategies to quantify genetic information were compared: A weighted genetic risk score including Metabochip SNPs associated with CHD in the literature (GRSMetabo); selection of the most predictive SNPs among these literature‐confirmed variants using priority‐Lasso (PLMetabo); validation of two comprehensive polygenic risk scores: GRSGola based on Metabochip data, and GRSKhera (available in the testset only) based on cross‐validated genome‐wide genotyping data. We used Cox regression to assess associations with incident CHD. C‐index, category‐free net reclassification index (cfNRI) and relative integrated discrimination improvement (IDIrel) were used to quantify the predictive performance of genetic information beyond Framingham risk score variables. In contrast to GRSMetabo and PLMetabo, GRSGola significantly improved the prediction (delta C‐index [95% confidence interval]: 0.0087 [0.0044, 0.0130]; IDIrel: 0.0509 [0.0131, 0.0894]; cfNRI improved only in cases: 0.1761 [0.0253, 0.3219]). GRSKhera yielded slightly worse prediction results than GRSGola.
Multitrait transcriptome‐wide association study (TWAS) tests
Authors: Feng Helian , Mancuso Nicholas , Pasaniuc Bogdan , Kraft Peter 
Published: June 2021

AbstractMultitrait tests can improve power to detect associations between individual single‐nucleotide polymorphisms (SNPs) and several related traits. Here, we develop methods for multi‐SNP transcriptome‐wide association (TWAS) tests to test the association between predicted gene expression levels and multiple phenotypes. We show that the correlation in TWAS test statistics for multiple phenotypes has the same form as multitrait statistics for the single‐SNP setting. Thus, established methods for combining single‐SNP test statistics across multiple traits can be extended directly to the TWAS setting. We performed an extensive evaluation across eight multitrait methods in simulations that varied gene‐phenotype effect sizes in addition to the underlying covariance structure among the phenotypes. We found that all multitrait TWAS tests have well‐calibrated Type I error (except ASSET, which can have a slightly elevated or depressed Type I error rate). Our results show that multitrait TWAS can improve statistical power compared with multiple single‐trait TWAS followed by Bonferroni correction. To illustrate our approach to real data, we conducted a multitrait TWAS of four circulating lipid traits from the Global Lipids Genetics Consortium. We found that our multitrait Wald TWAS approach identified 506 genes associated with lipid levels compared with 87 identified through Bonferroni‐corrected single‐trait TWAS. Overall, we find that our proposed multitrait TWAS framework outperforms single‐trait approaches to identify new genetic associations, especially for functionally correlated phenotypes and phenotypes with overlapping genome‐wide association studies samples, leading to insights into the genetic architecture of multiple phenotypes.
Conflict exposure and health: Evidence from the Gaza Strip
Authors: Di Maio Michele , Leone Sciabolazza Valerio 
Published: June 2021

AbstractWe study the impact of conflict exposure on health in the Gaza Strip using individual‐level longitudinal data and geo‐localized information on conflict‐related violent events. Results show that individuals living in localities exposed to more conflict events have a higher probability of suffering from a physical impairment and a chronic disease. Two mechanisms contribute to explain why living in conflict‐affected area increases the incidence of physical impairment: conflict increases the difficulty to reach health facilities and it decreases individual income. The conflict‐induced increase in the probability of having high blood pressure is instead consistent with the development of Post‐Traumatic Stress Disorder (PTSD) due to the exposure to conflict‐related violent events.
Perioperative pain management and opioid‐reduction in head and neck endocrine surgery: An American Head and Neck Society Endocrine Surgery Section consensus statement
Authors: Ferrell Jay K. , Shindo Maisie L. , Stack Brendan C. , Angelos Peter , Bloom Gary , Chen Amy Y. , Davies Louise , Irish Jonathan C. , Kroeker Teresa , McCammon Susan D. , Meltzer Charles , Orloff Lisa A. , Panwar Aru , Shin Jennifer J. , Sinclair Catherine F. , Singer Michael C. , Wang Tiffany V. , Randolph Gregory W. 
Published: June 2021

AbstractBackgroundThis American Head and Neck Society (AHNS) consensus statement focuses on evidence‐based comprehensive pain management practices for thyroid and parathyroid surgery. Overutilization of opioids for postoperative pain management is a major contributing factor to the opioid addiction epidemic however evidence‐based guidelines for pain management after routine head and neck endocrine procedures are lacking.MethodsAn expert panel was convened from the membership of the AHNS, its Endocrine Surgical Section, and ThyCa. An extensive literature review was performed, and recommendations addressing several pain management subtopics were constructed based on best available evidence. A modified Delphi survey was then utilized to evaluate group consensus of these statements.ConclusionsThis expert consensus provides evidence‐based recommendations for effective postoperative pain management following head and neck endocrine procedures with a focus on limiting unnecessary use of opioid analgesics.
Linking minimal and detailed models of CA1 microcircuits reveals how theta rhythms emerge and their frequencies controlled
Authors: Chatzikalymniou Alexandra Pierri , Gumus Melisa , Skinner Frances K. 
Published: June 2021

AbstractThe wide variety of cell types and their biophysical complexities pose a challenge in our ability to understand oscillatory activities produced by cellular‐based computational network models. This challenge stems from their high‐dimensional and multiparametric natures. To overcome this, we implement a solution by linking minimal and detailed models of CA1 microcircuits that generate intrahippocampal (3–12 Hz) theta rhythms. We leverage insights from minimal models to guide explorations of more detailed models and obtain a cellular perspective of theta generation. Our findings distinguish the pyramidal cells as the theta rhythm initiators and reveal that their activity is regularized by the inhibitory cell populations, supporting a proposed hypothesis of an “inhibition‐based tuning” mechanism. We find a strong correlation between input current to the pyramidal cells and the resulting local field potential theta frequency, indicating that intrinsic pyramidal cell properties underpin network frequency characteristics. This work provides a cellular‐based foundation from which in vivo theta activities can be explored.
Efficacy of amisulpride for depressive symptoms in individuals with mental disorders: A systematic review and meta‐analysis
Authors: Zangani Caroline , Giordano Barbara , Stein Hans‐Christian , Bonora Stefano , D'Agostino Armando , Ostinelli Edoardo Giuseppe 
Published: June 2021

AbstractBackgroundDepressive symptoms occur in several psychiatric disorders, often in the absence of a formal diagnosis of depression. We aimed to evaluate the efficacy and the tolerability of amisulpride, both alone and as augmentation therapy, in the treatment of depressive symptoms in individuals with any major psychiatric disorder.MethodsWe searched PubMed, Embase, PsycINFO, GreyLit, OpenGrey and ProQuest up to March 2020 for randomised controlled trials focussing on the treatment of an acute depressive episode in any major psychiatric disorder. A random‐effect meta‐analysis was performed to synthesize the findings on depressive symptoms (primary outcome), response rate and tolerability.ResultsWe retrieved 11 studies including 2065 patients with a diagnosis of dysthymia (eight studies), major depression (one study) or schizophrenia (two studies). Amisulpride 50 mg/day was associated with a larger reduction of depressive symptoms compared to placebo (standardised mean difference [SMD] = −0.70, CI 95% −0.92, −0.49; I2 = 0.0%), and was found to be comparable to selective serotonin reuptake inhibitors (SSRIs; SMD = −0.08, CI 95% −0.23, 0.06, I2 = 0.0%), amineptine, imipramine and amitriptyline in the treatment of dysthymia (three studies, not pooled). In individuals with schizophrenia, amisulpride administered at higher doses (>400 mg/day) was comparable to olanzapine and risperidone (two studies, not pooled). In terms of tolerability, amisulpride was superior to placebo for dysthymia (odds ratio [OR] = 3.94, CI 95% 1.07, 14.48; I2 = 0.0) and comparable with SSRIs (OR = 0.94, CI 95% 0.55, 1.62; I2 = 0.0%).ConclusionTreatment with amisulpride could be a valid choice for selected individuals with dysthymia or depressive symptoms in the context of schizophrenia. More studies on the efficacy and tolerability of amisulpride are needed to draw firm conclusions on its potential benefits in other psychiatric disorders.