bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demographic and clinical variables associated with response to clozapine in schizophrenia: a systematic review and meta-analysis
Authors: Griffiths Kira , Millgate Edward , Egerton Alice , MacCabe James H. 
Published: February 2021

AbstractClozapine is the only licensed pharmacotherapy for treatment-resistant schizophrenia. However, response to clozapine is variable. Understanding the demographic and clinical features associated with response to clozapine may be useful for patient stratification for clinical trials or for identifying patients for earlier initiation of clozapine. We systematically reviewed the literature to investigate clinical and demographic factors associated with variation in clozapine response in treatment-resistant patients with schizophrenia spectrum disorders. Subsequently, we performed a random-effects meta-analysis to evaluate differences in duration of illness, age at clozapine initiation, age of illness onset, body weight and years of education between clozapine responders and non-responders. Thirty-one articles were eligible for qualitative review and 17 of these were quantitatively reviewed. Shorter duration of illness, later illness onset, younger age at clozapine initiation, fewer hospitalisations and fewer antipsychotic trials prior to clozapine initiation showed a trend to be significantly associated with a better response to clozapine. Meta-analysis of seven studies, totalling 313 subjects, found that clozapine responders had a significantly shorter duration of illness compared to clozapine non-responders [g = 0.31; 95% confidence interval (CI) 0.06–0.56; p = 0.01]. The results imply that a delay in clozapine treatment may result in a poorer response and that a focus on prompt treatment with clozapine is warranted.
Longitudinal courses of suicidal ideation in U.S. military veterans: a 7-year population-based, prospective cohort study
Authors: Herzog Sarah , Tsai Jack , Nichter Brandon , Kachadourian Lorig , Harpaz-Rotem Ilan , Pietrzak Robert H. 
Published: February 2021

AbstractBackgroundVaried longitudinal courses of suicidal ideation (SI) may be linked to unique sets of risk and protective factors.MethodA national probability sample of 2291 U.S. veterans was followed over four assessments spanning 7 years to examine how a broad range of baseline risk and protective factors predict varying courses of SI.ResultsMost veterans (82.6%) denied SI at baseline and all follow-ups, while 8.7% had new onset SI, 5.4% chronic SI, and 3.3% remitted SI. Compared to the no-SI group, chronic SI was associated with childhood trauma, baseline major depressive and/or posttraumatic stress disorder (MDD/PTSD), physical health difficulties, and recent traumatic stressors. Remitted veterans had the highest risk of a prior suicide attempt (SA) compared to no-SI [relative risk ratio (RRR) = 3.31] and chronic SI groups (RRR = 4.65); and high rates of MDD/PTSD (RRR = 7.62). New onset SI was associated with recent stressors and physical health difficulties. All symptomatic SI groups reported decrements in protective factors, specifically, social connectedness, trait curiosity/exploration, and purpose in life.ConclusionNearly one-in-five veterans reported SI over a 7-year period, most of whom evidenced new onset or remitted SI courses. Chronic and remitted SI may represent particularly high-risk SI courses; the former was associated with higher rates of prospective SA, and psychiatric and physical distress, and the latter with increased likelihood of prior SA, and isolation from social and mental health supports. Physical disability, MDD/PTSD, and recent stressors may be important precipitating or maintaining factors of SI, while social connectedness may be a key target for suicide prevention efforts.
Clinical, cellular, and molecular characterisation of cardiac rhabdomyoma in tuberous sclerosis
Authors: Al Kindi Hamood N. , Ibrahim Ayman M. , Roshdy Mohamed , Abdelghany Besra S. , Yehia Dina , Masoud Ahmed Nageeb , Simry Walid , Aguib Yasmine , Yacoub Magdi H. 
Published: February 2021

AbstractBackground:Rhabdomyoma is the most common cardiac tumour in children. It is usually associated with tuberous sclerosis complex caused by mutations in TSC-1 or TSC-2 genes. This tumour typically regresses by unknown mechanisms; however, it may cause inflow or outflow obstruction that necessitates urgent surgery. Here we investigate the clinical features and the genetic analysis of patients with tuberous sclerosis complex presenting with large rhabdomyoma tumours. We also investigate the potential role of autophagy and apoptosis in the pathogenesis of this tumour.Methods:All the patients with cardiac rhabdomyoma referred to Aswan Heart Centre from 2010 to 2018 were included in this study. Sanger sequencing was performed for coding exons and the flanking intronic regions of TSC1 and TSC2 genes. Histopathological evaluation, immunohistochemistry, and western blotting were performed with P62, LC3b, caspase3, and caspase7, to evaluate autophagic and apoptotic signaling.Results:Five patients were included and had the clinical features of tuberous sclerosis complex. Three patients, who were having obstructive tumours, were found to have pathogenic mutations in TSC-2. The expression of two autophagic markers, P62 and LC3b, and two apoptotic markers, caspase3 and caspase7, were increased in the tumour cells compared to normal surrounding myocardial tissue.Conclusion:All the patients with rhabdomyoma were diagnosed to have tuberous sclerosis complex. The patients who had pathogenic mutations in the TSC-2 gene had a severe disease form necessitating urgent intervention. We also demonstrate the potential role of autophagy and apoptosis as a possible mechanism for tumourigenesis and regression. Future studies will help in designing personalised treatment for cardiac rhabdomyoma.
THOSE LEFT BEHIND
Authors: Dennis Alexis C. 
Published: February 2021

AbstractWhile the socioeconomic status (SES)–psychological distress gradient is well-documented in the social science literature, less attention has been devoted to how this relationship varies within sociodemographic subgroups. I contribute to this small but growing literature by first examining the relationship between multiple dimensions of SES and two measures of psychological distress (depression and anxiety) among working-age African Americans. I then test whether three social mediators explain the SES–psychological distress relationship, and whether gender modifies these associations and/or the social mediators that shape them. To address these aims, I analyze two waves of population-representative data from the Detroit Neighborhood Health Study (N=685). Data were collected between 2008 and 2010 in the wake of the Great Recession. I utilize structural equation modeling with latent variables to assess these relationships, and test indirect and conditional effects to detect the presence of mediation and/or moderation, respectively. Findings revealed associations between higher total household income and lower levels of depression/anxiety, as well as unemployment and increased depression/anxiety among working-age African Americans. Furthermore, higher educational attainment was associated with reduced anxiety, but not depression, in this population. Gender moderated these findings such that unemployment was associated with higher levels of depression/anxiety among women but not men. I also found that trauma mediated the relationship between unemployment and depression/anxiety as well as educational attainment and anxiety. Gender, however, moderated the association between unemployment and depression/anxiety via traumatic events such that the relationship was stronger among women than men. Collectively, these findings contribute to our limited understanding of African Americans’ mental health and underscore the importance of how both socioeconomic forces and life course experiences with traumatic events contribute to poor mental health among this population.
Drivers for Asynchronous Patterns of Dust Accumulation in Central and Eastern Asia and in Greenland During the Last Glacial Maximum
Authors: Cheng Liangqing , Song Yougui , Wu Yubin , Liu Yonggang , Liu Huifang , Chang Hong , Zong Xiulan , Kang Shugang 
Published: February 2021

AbstractWe collected 143 loess optically stimulated luminescence (OSL) ages between 10 ka and 30 ka from Central Asia (CA), and analyzed their probability density functions (PDFs). The PDFs show dust accumulation was greater during the late Last Glacial Maximum (LGM) (23–19 ka) than that during the early LGM (26.5–23 ka). The temporal variability of dust accumulation of CA loess is generally similar to that of Chinese Loess Plateau (CLP) loess, following precession. In contrast, dust accumulation in Greenland was stronger during the early LGM than that during the late LGM, following obliquity. Supported by numerical modeling experiments and our newly dating OSL ages, we conclude dust accumulation in CA and CLP during the LGM was controlled by Siberian High forced by precession, while dust accumulation in Greenland was closely related to both intensity of summer westerlies forced by obliquity, and to intensity of dust emissions at source forced by precession.
Universal behavior of the bosonic metallic ground state in a two-dimensional superconductor
Authors: Chen Zhuoyu , Wang Bai Yang , Swartz Adrian G. , Yoon Hyeok , Hikita Yasuyuki , Raghu Srinivas , Hwang Harold Y. 
Published: February 2021

AbstractAnomalous metallic behavior, marked by a saturating finite resistivity much lower than the Drude estimate, has been observed in a wide range of two-dimensional superconductors. Utilizing the electrostatically gated LaAlO3/SrTiO3 interface as a versatile platform for superconductor-metal quantum phase transitions, we probe variations in the gate, magnetic field, and temperature to construct a phase diagram crossing from superconductor, anomalous metal, vortex liquid, to the Drude metal state, combining longitudinal and Hall resistivity measurements. We find that the anomalous metal phases induced by gating and magnetic field, although differing in symmetry, are connected in the phase diagram and exhibit similar magnetic field response approaching zero temperature. Namely, within a finite regime of the anomalous metal state, the longitudinal resistivity linearly depends on the field while the Hall resistivity diminishes, indicating an emergent particle-hole symmetry. The universal behavior highlights the uniqueness of the quantum bosonic metallic state, distinct from bosonic insulators and vortex liquids.
Reconstructing phase-resolved hysteresis loops from first-order reversal curves
Authors: Gilbert Dustin A. , Murray Peyton D. , De Rojas Julius , Dumas Randy K. , Davies Joseph E. , Liu Kai 
Published: February 2021

AbstractThe first order reversal curve (FORC) method is a magnetometry based technique used to capture nanoscale magnetic phase separation and interactions with macroscopic measurements using minor hysteresis loop analysis. This makes the FORC technique a powerful tool in the analysis of complex systems which cannot be effectively probed using localized techniques. However, recovering quantitative details about the identified phases which can be compared to traditionally measured metrics remains an enigmatic challenge. We demonstrate a technique to reconstruct phase-resolved magnetic hysteresis loops by selectively integrating the measured FORC distribution. From these minor loops, the traditional metrics—including the coercivity and saturation field, and the remanent and saturation magnetization—can be determined. In order to perform this analysis, special consideration must be paid to the accurate quantitative management of the so-called reversible features. This technique is demonstrated on three representative materials systems, high anisotropy FeCuPt thin-films, Fe nanodots, and SmCo/Fe exchange spring magnet films, and shows excellent agreement with the direct measured major loop, as well as the phase separated loops.
Low-coverage whole-genome sequencing of extracellular vesicle-associated DNA in patients with metastatic cancer
Authors: Nguyen Bella , Wong Nicholas C. , Semple Tim , Clark Michael , Wong Stephen Q. , Leslie Connull , Mirzai Bob , Millward Michael , Meehan Katie , Lim Annette M. 
Published: February 2021

AbstractLow-coverage whole-genome sequencing (LC-WGS) can provide insight into oncogenic molecular changes. Serum extracellular vesicles (EV) represent a novel liquid biopsy source of tumoral DNA. This study compared copy number alteration (CNA) profiles generated from LC-WGS of formalin-fixed paraffin-embedded (FFPE) tumoral DNA and EV-DNA obtained from cancer patients. Patients with squamous cell carcinoma of the base of tongue (n = 3) and cutaneous squamous cell carcinoma (n = 2) were included. LC-WGS (0.5-1X coverage) was performed on FFPE-DNA and serum EV-DNA. Similarity between CNA profiles was analysed using QDNAseq. FFPE samples had a mean CNA of 31 (range 17–50) over 1.9 × 109 (range 1.0–2.6 × 109) bp in length, and EV samples had a mean CNA value of 17 (range 7–19) over 7.6 × 108 (range 2.9–15 × 108) bp in length. A mean of 8 (range 0–21) CNA over 5.9 × 108 (range 1.6–14 × 108) bp in length was found to overlap between EV and FFPE-derived samples per patient. Although the mean correlation efficient between samples was r = 0.34 (range − .08 to 0.99), this was not statistically significant (p > 0.05). Regions of highest deletion and duplication in FFPE samples were not well reflected in the EV-DNA. Selected CNA regions in EV-associated DNA were reflective of the primary tumor, however appreciation of global CNA and areas of most significant change was lost. The utility of LC-WGS of EV-derived DNA is likely limited to molecular alterations of known interest.
Reconstruction of full-length ureter defects by laparoscopic bladder flap forming
Authors: Bai Yuchen , Wei Haibin , Ji Alin , Zhang Qi , Wang Shuai , Peng Yonghan , Gao Xiaofeng , Liu Feng , Zhang Dahong 
Published: February 2021

AbstractTo evaluate the safety and efficacy of laparoscopic bladder muscle flap reconstruction in the treatment of extensive ureteral avulsion.
Patients with full-length (re length > 20 cm) and upper ureteral (avulsion length > 10 cm) defects were eligible. All patients were treated with laparoscopic bladder muscle flap reconstruction. Peri-operative information and post-operative complications were recorded. The kidney function, urinary ultrasound or computed tomography (CT), sun-renal function tests emission computed tomography (ECT) and cystography after operation were recorded. Ten patients were included (7 with full-length and 3 with upper ureteral defects). Median age was 56 years and 70% of them were female. The average operation time and blood loss was 124 min and 92.2 ml. There was no treatment-related adverse effects including urinary leakage, renal colic, fever, etc. The median follow-up was 18.5 months (3–39 months). The surgery did not significantly alter the renal function and separation degree of the renal pelvis during long-term follow-up. Double J stents were removed in nine patients (90%) within six months after operation. Only one case was diagnosed with post-operative anastomotic stricture, and subsequently received laparoscopic ipsilateral nephrectomy one year after the reconstruction operation. All cases had normal voiding and pear-shaped cystography. Laparoscopic bladder flap repair is a safe and effective treatment approach together with several advantages for patients with full-length or upper ureteral avulsion.
A comparative study of operative and conservative treatment of intraarticular displaced calcaneal fractures
Authors: Kamath K. Ramachandra , Mallya Sharan , Hegde Atmananda 
Published: February 2021

AbstractThe treatment of intra-articular displaced calcaneal fracture is debatable. We conducted a prospective study to compare operative and non-operative treatment for intra-articular displaced calcaneal fractures. Patients were assigned to two groups based on the treatment given (operative and nonoperative) and were regularly followed for a period of 1 year. The outcome measures were assessed by Modified Rowe’s Score (MRS), Visual Analogue e Scale (VAS) and The American Orthopaedic Foot and Ankle Society (AOFAS) scale. The outcome related to patient’s job was noted after one year and compared with pre-injury status. Fifty five patients with 61 calcaneal fractures were studied. Thirty of them were operated and 31 were treated conservatively. Out of 30 operated cases, Bohler’s angle was restored in 25 cases and these had good results with all three outcome scores at 1 year follow up and remaining 5 cases showed fair results (Mean MRS: 74.783, VAS: 3.348, AOFAS: 78.783). Thirty one cases treated with cast also showed fair results (Mean MRS: 57.368, VAS: 4.944, AOFAS: 71.211). The overall outcome of operated cases were better than non-operated cases (unpaired T test MRS: 5.807 p < 0.001, VAS: 4.387 p < 0.001, AOFAS: 2.728 p = 0.008) . Operative treatment of displaced intra-articular calcaneal fractures gave good results at one year follow up, provided Bohler’s angle was restored to normal range. Non operative treatment gave fair results. Complications were seen both with operative and non-operative treatment.
Source forensics of inorganic and organic nitrogen using δ15N for tropospheric aerosols over Mt. Tai
Authors: Wu Libin , Yue Siyao , Shi Zongbo , Hu Wei , Chen Jing , Ren Hong , Deng Junjun , Ren Lujie , Fang Yunting , Yan Hong , Li Weijun , Harrison Roy M. , Fu Pingqing 
Published: February 2021

AbstractNitrogen-containing species are major components in atmospheric aerosols. However, little is known about the sources of N-containing aerosols over high mountainous regions, especially for organic nitrogen (ON). This study aims to reveal the emission sources of both inorganic and organic nitrogen in tropospheric aerosols atop Mt. Tai, China, and to improve our understanding of the N cycle imbalance in the North China Plain (NCP). Total suspended particle (TSP) samples were collected on a daytime/nighttime basis in spring 2017 and were investigated for the concentrations and stable N isotopic compositions of total nitrogen, NH4+, NO3− and ON. Our results show that the concentrations of N-containing compounds were higher in daytime than nighttime, mainly resulting from mountain–valley breezes and the changes of planetary boundary layer height. However, no significant day/nighttime changes were found for their corresponding δ15N values, indicating similar contributions from different N sources between day and night. The MixSIAR Bayesian stable isotope mixing model results suggest that the most important emission source of NH3 for aerosol NH4+ was agriculture, followed by fossil fuel-related sources, human waste and biomass burning. Aerosol NO3− was mainly formed from combustion and mobile emitted NOx. Interestingly, the isotopes of ON suggest that ON were very likely firstly of primary origin. Our study reveals the characteristics of reactive N emission sources and helps understand the regional transport of tropospheric N-containing aerosols in the NCP.
2D graphene oxide–aptamer conjugate materials for cancer diagnosis
Authors: Sekhon Simranjeet Singh , Kaur Prabhsharan , Kim Yang-Hoon , Sekhon Satpal Singh 
Published: February 2021

Abstract2D graphene oxide (GO) with large surface area, multivalent structure can easily bind single-stranded DNA/RNA (aptamers) through hydrophobic/π-stacking interactions, whereas aptamers having small size, excellent chemical stability and low immunogenicity bind to their targets with high affinity and specificity. GO–aptamer conjugate materials synthesized by integrating aptamers with GO can thus provide a better alternative to antibody-based strategies for cancer diagnostic and therapy. Moreover, GO’s excellent fluorescence quenching properties can be utilized to develop efficient fluorescence-sensing platforms. In this review, recent advances in GO–aptamer conjugate materials for the detection of major cancer biomarkers have been discussed.
Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors
Authors: York H. M. , Patil A. , Moorthi U. K. , Kaur A. , Bhowmik A. , Hyde G. J. , Gandhi H. , Fulcher A. , Gaus K. , Arumugam S. 
Published: February 2021

AbstractThe endosomal system provides rich signal processing capabilities for responses elicited by growth factor receptors and their ligands. At the single cell level, endosomal trafficking becomes a critical component of signal processing, as exemplified by the epidermal growth factor (EGF) receptors. Activated EGFRs are trafficked to the phosphatase-enriched peri-nuclear region (PNR), where they are dephosphorylated and degraded. The details of the mechanisms that govern the movements of stimulated EGFRs towards the PNR, are not completely known. Here, exploiting the advantages of lattice light-sheet microscopy, we show that EGFR activation by EGF triggers a transient calcium increase causing a whole-cell level redistribution of Adaptor Protein, Phosphotyrosine Interacting with PH Domain And Leucine Zipper 1 (APPL1) from pre-existing endosomes within one minute, the rebinding of liberated APPL1 directly to EGFR, and the dynein-dependent translocation of APPL1-EGF-bearing endosomes to the PNR within ten minutes. The cell spanning, fast acting network that we reveal integrates a cascade of events dedicated to the cohort movement of activated EGF receptors. Our findings support the intriguing proposal that certain endosomal pathways have shed some of the stochastic strategies of traditional trafficking and have evolved processes that provide the temporal predictability that typify canonical signaling.
Synthesis of 1,10-decanediol diacetate and 1-decanol acetate from furfural
Authors: Deng Chen-Qiang , Jiang Qin-Zhu , Deng Jin , Fu Yao 
Published: February 2021

Furfural was converted into furoin by immobilized NHC catalyst, and then furoin was upgraded into 1,10-decanediol diacetate and 1-decanol acetate by Pd/C catalytic hydrodeoxygenation reaction promoted with Sc(OTf)3 in acetic acid.
Eye Tracking Measures for Studying Language Comprehension Deficits in Aphasia: A Systematic Search and Scoping Review
Authors: Sharma Saryu , Kim Hana , Harris Havan , Haberstroh Amanda , Wright Heather Harris , Rothermich Kathrin 
Published: February 2021

Aim
The aim of this scoping review is to identify the eye tracking paradigms and eye movement measures used to investigate auditory and reading comprehension deficits in persons with aphasia (PWA).

Method
MEDLINE via PubMed, Cochrane, CINAHL, Embase, PsycINFO, OTseeker, Scopus, Google Scholar, Grey Literature Database, and ProQuest Search (Dissertations & Theses) were searched for relevant studies. The Covidence software was used to manage the initial and full-text screening process for the search.

Results and Discussion
From a total of 1,803 studies, 68 studies were included for full-text screening. In addition, 418 records from gray literature were also screened. After full-text screening, 16 studies were included for this review—12 studies for auditory comprehension in PWA and four studies for reading comprehension in PWA. The review highlights the use of common eye tracking paradigms used to study language comprehension in PWA. We also discusse eye movement measures and how they help in assessing auditory and reading comprehension. Methodological challenges of using eye tracking are discussed.

Conclusion
The studies summarized in this scoping review provide evidence that the eye tracking methods are beneficial for studying auditory and reading comprehension in PWA.