bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse childhood experiences and trajectories of psychological distress in adulthood: an analysis of the 1958 British birth cohort
Authors: Gondek Dawid , Patalay Praveetha , Sacker Amanda , Gagné Thierry , Danese Andrea , Lacey Rebecca E 
Published: May 2021

AbstractBackgroundThe evidence on the association between adverse childhood experiences (ACEs) and psychological distress in adulthood tends to rely on cross-sectional studies. In this 50-year long longitudinal study, we examined the association between both prospectively and retrospectively reported ACEs and adulthood trajectories of psychological distress between age 23 and 50. We also studied potential effect modifiers of these associations, spanning social and developmental domains of child development.MethodsThe sample comprised 8,055 participants of the 1958 National Child Development Study. Psychological distress was measured by the Malaise Inventory at ages 23-50. We used growth curve analysis and multinomial regression.ResultsAfter accounting for covariates, those with more ACEs experienced persistently higher psychological distress between age 23 and 50, with a graded relationship observed. The associations were relatively consistent across prospectively and retrospectively reported ACEs. Those with prospective or retrospective ACE score of 1 compared with 0, had on average between 0.27 and 0.39 higher distress throughout adulthood. In relative terms, the prospective ACE score of 2+ (vs 0) was associated with 3.31 and the retrospective ACE score of 4+ (vs 0) with 5.76 (95% CI 4.24 to 7.82) times higher risk of being in the “high symptoms”, compared with the “low symptoms” trajectory of distress. None of the potential effect modifiers altered the association between ACEs and trajectories of distress.ConclusionIf the associations between ACEs and trajectories of distress are causal, this emphasises the need to act early to prevent psychopathology across the adult life course.
Divergent sex differences in functional brain connectivity networks in excessively drinking C57BL/6J mice
Authors: Bloch Solal , Rinker Jennifer A. , Smith Alex C.W. , Shiromani Priyattam J. , Wheeler Damian G. , Azevedo Ricardo , Gandhi Sunil , Hoffman Michaela , Mulholland Patrick J. 
Published: May 2021

AbstractIndividuals with alcohol use disorder continue to drink in excess despite the health and societal consequences, and the rate of problematic drinking and alcohol-related harms is increased in women. Clinical imaging studies report widespread adaptations in brain structure after chronic, heavy drinking, and alcohol-related cues enhance brain reactivity in reward-related regions. In rodents, alcohol drinking induces expression of the immediate early gene c-Fos, which can be a marker of cellular activity, across multiple brain regions. Recent evidence also suggests that abstinence from chronic intermittent alcohol exposure can produce mesoscale changes in c-Fos expression. However, there is a substantial gap in our understanding of how excessive drinking affects functional connectivity networks to influence alcohol-seeking behaviors. For this study, male and female C57BL/6J mice were given access to either water or a choice between water and ethanol in the intermittent access drinking model for 4 weeks. After a short-access drinking session, whole brains from high alcohol drinking male and female mice and water drinking controls were then subjected to c-Fos immunolabeling, iDISCO+ clearing, light sheet imaging, and whole-brain c-Fos mapping. Correlation matrices were then generated and graph theoretical statistical approaches were used to determine changes in functional connectivity across sex and drinking condition. We observed robust sex differences in the network of c-Fos+ cells in water drinking mice, and excessive alcohol drinking produce divergent and robust changes in functional network connectivity in male and female mice. In addition, these analyses identified novel hub regions in excessively drinking mice that were unique for each sex. In conclusion, the whole-brain c-Fos mapping analysis identified sex difference in functional network connectivity and unique and understudied regions that may play a critical role in controlling excessive ethanol drinking in male and female mice.
A model for thermal comfort assessment of naturally ventilated housing in the hot and dry tropical climate
Authors: Ouedraogo Arnaud Louis Sountong-Noma , Messan Adamah , Yamegueu Daniel , Coulibaly Yezouma 
Published: May 2021

PurposeA major challenge faced by West Africa is to find comfortable housing as a result of climate change and population growth. The climatic adaptation of buildings and their indoor environment become an essential condition for maintaining the health and productivity of the occupants. This paper proposes a model to assess the thermal comfort of naturally ventilated buildings in hot and dry climates in Burkina Faso.Design/methodology/approachThe proposed method is an adaptive model which relies on a combination of parameters such as the operative temperature, the new effective temperature and the basic parameters of thermal comfort. It consists in proposing the zones of thermal comfort on the diagram of the humid air for each climatic region.FindingsA decision-making tool is set up for evaluating the comfort of buildings to better consider the bio-climatic concept through a long-term comfort index. This comfort index is defined and is used to assess the degree of thermal discomfort for various types of housing. Two natural ventilation pilot buildings located in Ouagadougou were considered. The results show that the pilot building whose wall are is made of Earth blocks achieves 26.4% of thermal comfort while the building made of hollow cement block achieves 25.8% of thermal comfort.Originality/valueThe decision-making tool proposed in the present study allow building stakeholders to better and easily design, assess and improve the thermal environment of buildings.
Does social support at work enhance subjective career success? The mediating role of relational attachment
Authors: Kundi Yasir Mansoor , Soomro Shuaib Ahmed , Kamran Muhammad 
Published: May 2021

Purpose
Drawing on Kahn’s model of meaningful connections, this study aims to examine relational attachment as a mediating mechanism linking social support in terms of instrumental support and personal support to employees’ subjective career success.

Design/methodology/approach
Data were collected in 2 waves from 247 employees working in Poland. Hypotheses were tested using structural equation modeling in AMOS.

Findings
The findings indicated that employees are more attached to and satisfied with their careers when they have a stronger relational attachment to others at work. Furthermore, relational attachment was found to be driven by tangible or intangible instrumental support received at work rather than the personal support received at work.

Practical implications
Managers should recognize the importance of workplace relationships and social support, which can lead to higher career commitment and career satisfaction. However, managers should keep in mind that too much interference in individuals’ privacy and providing too much personal support may lead to adverse outcomes.

Originality/value
The present study expands the scant literature on the mediating role of relational attachment at work between social support received at work and subjective career success.
Steel truss bridge vibration-based condition monitoring using Savitzky-Golay filter, Hilbert transform, MUSIC and ESPRIT
Authors: Sharma Anshul , Kumar Pardeep , Vinayak Hemant Kumar , Patel Raj Kumar , Walia Suresh Kumar 
Published: May 2021

Purpose
This study aims to perform the experimental work on a laboratory-constructed steel truss bridge model on which hammer blows are applied for excitation. The vibration response signals of the bridge structure are collected using sensors placed at different nodes. The different damaged states such as no damage, single damage, double damage and triple damage are introduced by cutting members of the bridge. The masked noise with recorded vibration responses generates challenge to properly analyze the health of bridge structure.

Design/methodology/approach
The analytical modal properties are obtained from finite element model (FEM) developed using SAP2000 software. The response signals are analyzed in frequency domain by power spectrum and in time-frequency domain using spectrogram and Stockwell transform. Various low pass signal-filtering techniques such as variational filter, lowpass sparse banded (AB) filter and Savitzky–Golay (SG) differentiator filter are also applied to refine vibration signals. The proposed methodology further comprises application of Hilbert transform in combination with MUSIC and ESPRIT techniques.

Findings
The outcomes of SG filter provided the denoised signals using appropriate polynomial degree with proper selected window length. However, certain unwanted frequency peaks still appeared in the outcomes of SG filter. The SG-filtered signals are further analyzed using fused methodology of Hilbert transform-ESPRIT, which shows high accuracy in identifying modal frequencies at different states of the steel truss bridge.

Originality/value
The sequence of proposed methodology for denoising vibration response signals using SG filter with Hilbert transform-ESPRIT is a novel approach. The outcomes of proposed methodology are much refined and take less computational time.
Easing the multiplicative effects of abusive supervision
Authors: Abi Aad Amine , Andrews Martha C. , Maalouf Jamal T. , Kacmar K. Michele , Valle Matthew 
Published: May 2021

PurposeAbusive supervision research has clearly demonstrated its many negative effects. The present study uses social learning theory to shed light on mechanisms that could potentially alter the negative effect of abusive supervision.Design/methodology/approachUsing a sample of 162 full-time employees, we identify and test two potential variables that we believe may moderate, or soften, the trickle-down negative effects of abusive supervision.FindingsResults demonstrates that coworker support moderates the positive relationship between abusive supervision and coworker incivility such that this relationship is weaker when coworker support is high. In addition, we found that work engagement moderates the positive relationship between coworker incivility and turnover intentions such that this relationship is weaker when engagement is high. Next, we found that coworker incivility mediates the positive relationship between abusive supervision and turnover intentions and that this indirect effect is moderated by both coworker support and work engagement.Originality/valueWe combined three theoretical explanations, social learning theory, contagion effect and the trickle-down perspective, to theoretically argue not only how (through coworker incivility) but when (when coworker support and work engagement are low) abusive supervision impacts turnover intentions. In addition, we extended the research on work engagement by positioning it as a boundary condition. We found that when individuals are engaged in their work, the environment in which they work matters less (because the work matters more).
Work ability and quality of working life in atopic dermatitis patients treated with dupilumab
Authors: Bosma Angela L. , Ouwerkerk Wouter , Günal Merve , Hyseni Ariënna M. , Arents Bernd W. M. , Gerbens Louise A. A. , Middelkamp‐Hup Maritza A. , de Boer Angela G. E. M. , Spuls Phyllis I. 
Published: May 2021

AbstractAtopic dermatitis is associated with work productivity loss. Little is known about how patients perceive their work ability and quality of working life, and how this is affected by treatment. Our primary objective was to investigate work ability and quality of working life at baseline and during treatment in the long term. A registry‐embedded prospective observational cohort study was conducted consisting of patients with atopic dermatitis starting dupilumab in routine clinical care. The instruments used were the Work Ability Index (WAI; questions 1, 2, and 3) and the Quality of Working Life Questionnaire (QWLQ). Ninety‐three patients were included of whom 72 were (self‐)employed (77%). From baseline to 48 weeks, the mean WAI‐1 score (general work ability, range 0–10) improved from 6.8 (±2.0) to 7.9 (±1.3), WAI‐2 (physical work ability, range 1–5) from 3.7 (±0.9) to 4.3 (±0.7), and WAI‐3 (mental/emotional work ability, range 1–5) from 3.4 (±0.9) to 3.9 (±0.8) (p = 0.001, p = 0.005, p < 0.001, respectively). The mean QWLQ total score improved from 74.0 (±9.1) to 77.5 (±9.6) and subscale “Problems due to health situation” improved from 37.4 (±22.3) to 61.5 (±23.1) (range 0–100; p = 0.032, p < 0.001, respectively). In conclusion, patients with moderate‐to‐severe atopic dermatitis starting dupilumab report decreased work ability and quality of working life, mainly due to health‐related problems. Significant improvement of work ability and quality of working life is observed with dupilumab treatment.
Biodiversity dataset of vascular plants and birds in Chinese urban greenspace
Authors: Wang Xin , Liu Jun , Liang Chenxia , Zhao Zhichun , Feng Gang , Zhang Jian 
Published: May 2021

AbstractUrban greenspace plays an important role in buffering the threat of urbanization to biodiversity. Biodiversity research in urban greenspace is essential for understanding the impacts of human activities on biodiversity and the associated ecosystem functioning and services in urban ecosystems. However, we lack large‐scale biodiversity datasets in urban greenspace for macroecological studies. In this paper, we provided a comprehensive biodiversity dataset of vascular plant and bird species in 286 university campuses and 118 urban parks in 143 cities in China, covering a wide range with different levels of urbanization (20–50°N in latitude and 81–130°E in longitude). Plant species were classified into different growth forms, and bird species were identified as resident or migrant. In total, the dataset contains 46,558 occurrence records for 5,915 plant species (about 18% of all Chinese vascular plant species) and 6,423 records for 546 bird species (around 40% of all recorded bird species in China). This dataset provides an important data source for evaluating the anthropogenic effects of biodiversity changes and advancing urban ecology. The complete data set for this abstract published in the Data Paper section of the journal is available in electronic format in MetaCat in JaLTER at http://db.cger.nies.go.jp/JaLTER/metacat/metacat/ERDP-2021-02.1/jalter-en.
Molting process revealed by the detailed expression profiles of RXR1/RXR2 and mining the associated genes in a spider mite, Panonychus citri
Authors: Li Gang , Liu Xun‐Yan , Smagghe Guy , Niu Jin‐Zhi , Wang Jin‐Jun 
Published: May 2021

AbstractSpider mites have one ecdysone receptor (EcR) and multiple retinoid X receptors (RXRs). However, the function of these RXRs in spider mite development is unknown. Here, we screened the expression dynamics of two PcRXR isoforms at 4 h intervals in the deutonymphal stage of Panonychus citri. The results showed that PcEcR had an expression pattern similar to that of PcRXR2. For PcRXR1, its expression remained at a certain high level, when there was a decrease of both PcEcR and PcRXR2. In situ hybridization showed that PcRXR2 was detected in the central nervous mass, while the ecdysteroid biosynthesis gene PcSpo was mainly expressed at the edge of the central nervous mass. RNAi‐based silencing of PcRXR1 or PcRXR2 showed the same phenotype as in mites with that of silencing PcEcR. Furthermore, RNA‐seq was used to mine the genes associated with the expression dynamics of PcRXR1 or PcRXR2, which revealed that the heterodimer of EcR‐RXR2 in spider mites might be linked with the cell autophagy and tissue remodeling during apolysis, and RXR1 might be linked with new epicuticle and exocuticle secretion during ecdysis. Taken together, these results increase our understanding of the regulation mechanism of ecdysteroid signal pathway in spider mite development.
The impact of antineutrophil cytoplasmic antibody‐associated vasculitis on employment and work disability in an Australian population
Authors: Heron Vanessa , Gingold Michael , Kitching Arthur R. , Polkinghorne Kevan R. , Ryan Jessica 
Published: May 2021

AbstractAimAlthough antineutrophil cytoplasmic antibody‐associated vasculitis (AAV) most commonly affects older individuals, many patients develop the disease during their most productive working years. The aim of this study was to examine the effects of AAV on employment and work disability in a cohort of Australian patients of working age.MethodsPatients attending a vasculitis clinic located in Melbourne, Australia, completed an employment questionnaire in addition to the Work Productivity and Activity Impairment Questionnaire: Specific Health Problem.ResultsThe average age of the 47 respondents was 47.8 ± 11.9 years (range 22‐63 years), with a median disease duration of 60 months (range 10.2‐318.5 months). There were 68.1% who were currently employed, but 20.6% of respondents employed at the time of diagnosis were no longer working and 10.6% had experienced a significant reduction in work hours since their diagnosis. There were 12.7% who were dependent on the disability support pension. The rate of work disability was 23.4%. Many participants considered themselves work impaired (41.9%), with 10.1% having missed work in the previous week. Furthermore, 44.7% of respondents reported that their financial stability had been negatively impacted by their vasculitis diagnosis. Fatigue was commonly reported. Work disabled patients were significantly more likely to be obese and less likely to have completed a tertiary education. Work disabled patients tended to be older, myeloperoxidase‐antineutrophil cytoplasmic antibody positive, and have renal involvement and lung involvement.ConclusionA proportion of people living with AAV in Australia experience a decline in employment and an increase in work disability when living with this condition.
Improving quality and efficiency of care for advanced appendicitis in children
Authors: Do‐Wyeld Montgommery , Cundy Thomas P. , Court‐Kowalski Stefan , Dandie Lynda , Cooper Celia , Burgoyne Laura , Cooksey Rebecca , Khurana Sanjeev 
Published: May 2021

AbstractBackgroundComplicated appendicitis encompasses a spectrum of severity with heterogeneity in definition and substantial variation in care. Enhanced recovery after surgery or ‘fast‐track’ protocols aim to reduce practice variation by standardizing care. These initiatives may improve quality and efficiency of care, preserve resources and expedite discharge. This study aims to evaluate the impact of a standardized Enhanced Recovery Pathway (ERP) on the post‐operative recovery of children with a subset of complicated appendicitis termed ‘advanced’ appendicitis.MethodsWe defined advanced appendicitis as gangrenous or suppurative appendicitis without perforation, contained iatrogenic perforation, or localized purulent fluid. Children with operative findings reflecting these criteria were enrolled in the ERP protocol. Key protocol components include early upgrade of diet, avoidance of intravenous analgesia, abridged intravenous antibiotics, early ambulation and standardized discharge criteria. The study period was May 2018 to June 2019. A historical cohort was used as the comparator group.ResultsOutcomes for 44 children treated under the ERP were compared to 44 historical controls. There was a 20% reduction in median post‐operative length of stay (1.80 vs. 2.24 days, p = 0.02). Intravenous analgesia was received by fewer patients (6.8% vs. 36.4%, p = 0.01) with significant reduction in antiemetic requirement (p = 0.03). No significant difference in 30‐day complication rates was observed.ConclusionReduced post‐operative length of stay and reduction in practice variation were achieved after implementation of a ‘fast‐track’ protocol for children with advanced appendicitis. Additional benefits of this protocol include reduced provision of intravenous morphine analgesia, decreased resource use and cost savings.
Histological disease activity in patients with microscopic colitis is not related to clinical disease activity or long‐term prognosis
Authors: Olsen Lærke Müller , Engel Peter Johan Heiberg , Goudkade Danny , Villanacci Vincenzo , Thagaard Jeppe , Walbech Julie Sparholt , Bohr Johan , Kupcinskas Juozas , Verhaegh Bas , Münch Andreas , Guagnozzi Danila , Fernández‐Bañares Fernando , Munck Lars Kristian , Fiehn Anne‐Marie Kanstrup 
Published: May 2021

SummaryBackgroundMicroscopic colitis (MC) is a common cause of chronic watery diarrhea. Biopsies with characteristic histological features are crucial for establishing the diagnosis. The two main subtypes are collagenous colitis (CC) and lymphocytic colitis (LC) but incomplete forms exist. The disease course remains unpredictable varying from spontaneous remission to a relapsing course.AimTo identify possible histological predictors of course of disease.MethodsSixty patients from the European prospective MC registry (PRO‐MC Collaboration) were included. Digitised histological slides stained with CD3 and Van Gieson were available for all patients. Total cell density and proportion of CD3 positive lymphocytes in lamina propria and surface epithelium were estimated by automated image analysis, and measurement of the subepithelial collagenous band was performed. Histopathological features were correlated to the number of daily stools and daily watery stools at time of endoscopy and at baseline as well as the clinical disease course (quiescent, achieved remission after treatment, relapsing or chronic active) at 1‐year follow‐up.ResultsNeither total cell density in lamina propria, proportion of CD3 positive lymphocytes in lamina propria or surface epithelium, or thickness of collagenous band showed significant correlation to the number of daily stools or daily watery stools at any point of time. None of the assessed histological parameters at initial diagnosis were able to predict clinical disease course at 1‐year follow‐up.ConclusionsOur data indicate that the evaluated histological parameters were neither markers of disease activity at the time of diagnosis nor predictors of disease course.
In silico prediction of drug‐induced ototoxicity using machine learning and deep learning methods
Authors: Huang Xin , Tang Fang , Hua Yuqing , Li Xiao 
Published: May 2021

AbstractDrug‐induced ototoxicity has become a serious global problem, because of leading to deafness in hundreds of thousands of people every year. It always results from exposure to drugs or environmental chemicals that cause the impairment and degeneration of the inner ear. Herein, we focused on the in silico modeling of drug‐induced ototoxicity of chemicals. We collected 1,102 ototoxic medications and 1,705 non‐ototoxic drugs. Based on the data set, a series of computational models were developed with different traditional machine learning and deep learning algorithms implemented on an online chemical database and modeling environment. Six ML models performed best on 5‐fold cross‐validation and test set. A consensus model was developed with the best individual models. These models were further validated with an external validation. The consensus model showed best predictive ability, with high accuracy of 0.95 on test set and 0.90 on validation set. The consensus model and the data sets used for model development are available at https://ochem.eu/model/46566321. Besides, 16 structural alerts responsible for drug‐induced ototoxicity were identified. We hope the results could provide meaningful knowledge and useful tools for ototoxicity evaluation in drug discovery and environmental risk assessment.