bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penambahan Nanoselulosa Sekam Padi Terhadap Kekasaran Permukaan Basis Gigi Tiruan Resin Akrilik Polimerisasi Panas
Authors: Rahmawati Selma Junita , Logamarta Setiadi Warata , Satrio Rinawati 
Published: November 2021

Basis gigi tiruan adalah bagian yang berkontak langsung dengan jaringan lunak rongga mulut. Bahan basis gigi tiruan yang paling umum digunakan yaitu resin akrilik polimerisasi panas. Bahan ini masih memiliki kekurangan yaitu sifat mekanis rendah, meninggalkan monomer sisa dan adanya porositas yang berpengaruh terhadap kekasaran permukaan. Nanoselulosa sekam padi memiliki potensi sebagai alternatif untuk memperbaiki sifat bahan resin akrilik polimerisasi panas. Nanoselulosa memiliki keunggulan diantaranya memiliki luas permukaan yang tinggi sehingga dapat digunakan sebagai reinforcing nanofiller pada material komposit seperti resin akrilik. Tujuan penelitian ini adalah untuk mengetahui pengaruh penambahan nanoselulosa sekam padi terhadap kekasaran permukaan pada resin akrilik polimerisasi panas. Jenis penelitian ini adalah eksperimental laboratoris dengan post-test only control group design. Sampel penelitian terdiri dari 6 kelompok, masing-masing kelompok terdiri dari 8 sampel. Kelompok K1, K2, K3, K4, K5 dan K0 berturut-turut merupakan kelompok dengan penambahan nanoselulosa 1%, 2%, 3%, 4%, 5% serta kontrol (tanpa nanoselulosa). Hasil penelitian menunjukkan semua kelompok dengan penambahan nanoselulosa memiliki nilai kekasaran permukaan lebih tinggi dibanding kelompok kontrol. Penambahan nanoselulosa 5% (K5) memiliki nilai kekasaran permukaan tertinggi yaitu 0,3242 ± 0.0066µm kemudian diikuti berturut-turut oleh kelompok K4, K3, K2, K1 dan kelompok kontrol (K0) memiliki nilai kekasaran permukaan terendah yaitu 0.1558 ± 0.0023µm. Hasil uji SEM pada setiap kelompok menunjukkan terdapat aglomerasi dan ukuran porus yang bervariasi. Kesimpulan penelitian ini adalah penambahan nanoselulosa sekam padi tidak lebih baik dari kelompok kontrol dan dapat meningkatan kekasaran permukaan basis gigi tiruan resin akrilik polimerisasi panas.
Isolated Renal Hydatid Cyst in a 6-Year-Old Boy: A Case Report
Authors: Demir Mehmet , Yağmur İsmail 
Published: November 2021

Hydatid cyst (HC) is a parasitic infection transmitted by oral ingestion of Echinococcus granulosus eggs. Isolated kidney involvement is extremely rare. It is even less common in children. We present a case of isolated renal HC in a 6-year-old boy from Şanlıurfa, southeast Turkey who complained of abdominal pain and distension. Cystectomy was performed with a flank incision using the extraperitoneal approach. No recurrence was detected in the postoperative 6-month follow-up. There are not enough data about the efficacy of medical treatment in renal HC. Therefore, medical treatment should be considered pre- and post-operatively to prevent dissemination, rather than being used as a primary treatment. Kidney-sparing surgery should be the first choice in patients with isolated renal HC. However, nephrectomy is recommended for nonfunctioning kidneys, large cysts thought to be connected with the collecting system, and cysts with suspicious tumor. In societies where HC disease is endemic, renal HC should be considered in children with cysts located in kidney, even if the indirect hemagglutination test is negative.
Efektivitas Pesan Dakwah di Media Sosial Terhadap Religiusitas Masyarakat Muslim: Analisis Literature Review
Authors: Uddin Syaif , Muhid Abdul 
Published: November 2021

Media sosial menjadi alternative dalam menyampaikan pesan-pesan dakwah, sehingga tidak sedikit para pelaku dakwah menggunakan media sebagai sarananya. Kompleksnya media mengharuskan para da’i untuk terlibat ke dunia media, dari hal ini media sosial tentunya adalah komunikasi dakwah yang efektif dalam mengimbangi perkembangan zaman. Oleh karena itu studi literature review ini bertujuan untuk mengetahui efektifitas pesan dakwah dimedia sosial terhadap religiusitas masyarakat muslim. Lebih lanjut kajian mendalam terhadap efektiftasnya media dakwah perlu dilakukan, karena semakin pesatnya perkembangan dan penggunaan media. Selanjutnya dalam proses analisis, peneltian ini menggunakan metode studi literature dengan mengumpulkan beragam sumber dari jurnal, artikel, serta buku-buku yang berhubungan dengan variabel penelitian. Hasil dari studi literture ini menunjukkan bahwa efektifitas dakwah media sosial bisa dikatakan efektif apabila frekuensi dari intensitas seseorang menggunakan media kemudian mengamalkan isi pesan yang disampaikan terkait kajian dakwah yang ada.
​The Analysis of Reproduction-related Genes Provides Insights into the Adaptive Evolution of Fecundity Traits in Yangtze Finless Porpoise
Authors: Bin Wu , Weiping Wang , Huan Zhang 
Published: November 2021

Background: Yangtze finless porpoise (YFP, Neophocaena asiaeorientalis), is the first class protected animal in China. In order to analyze the adaptive evolution of fecundity traits in YFP, the rapidly evolving gene families of YFP were obtained. At the same time, the major genes controlling ovulation, GDF9, BMP15, FSHβ and FSHR were also analyzed. Methods: Orthofinder software was employed to search homologous genes based on protein sequence. CAFÉ software was used to obtain the expansion and contraction gene families of YFP. Then, GO terms and pathway enrichment analyses were performed using TBtools software and Swissprot database. PAML package was used to calculate Ka/Ks (i.e., ω). Evolution rate changes in the positive selected genes were examined using the GU99 process in Diverge (v3.0) program. Result: In YFP, 501 rapid expansion gene families GO enrichment results showed that the reproductive activities related pathways were mainly three significant enrichment process, participation of germline stem cells maintain androgen receptors signaling pathways regulating and male reproductive tract stem cell population to maintain. The most significant GO terms of 220 rapidly contraction gene families associated with reproductive activities mainly consisted of biological processes which were involved in positive regulation of estrogen secretion, mating and estrogen metabolic process. GDF9 and BMP15 genes exhibited purifying selection. However, significant signs of positive selection were detected in FSHR and FSHβ genes, but only FSHβ showed specific changes in the YFP lineage.
IMPLEMENTATION INTERNAL CONTROL SYSTEM GOVERNMENT WITH GOVERNMENT REGULATION RELEASE OF NO. 60/2008 IN KPU JEMBER REGENCY: A PHENOMENOLOGY APPROACH
Authors: SUGIYONO SUKMA ULI NUHA , Miqdad Muhammad Miqdad , Sulistiyo Agung Budi Sulistiyo 
Published: November 2021

According to the Government Regulation of the Republic of Indonesia Number 60 of 2008 concerning the Government's Internal Control System, SPIP is an internal control system that is carried out thoroughly within the Central Government and Regional Governments. The important role of the SPIP is expected to create a culture of supervision over all activities in the entity so that early on it can detect the possibility of storage and minimize the occurrence of actions that can harm the state. SPIP which consists of elements of the Control Environment, Risk Assessment, Control Activities, Information and Communication, and Control Monitoring.The work of the KPU, both in Jember and other regions, is a phased work, which focuses on elections at both the central and regional levels so that the focus of work at this stage is that at this time SPIP reporting is only for administrative purposes. This is the reason why the author describes the phenomena that exist in the field, with the hope that in the future it will not only be an administrative complement but can be used as a control to increase the effectiveness of management at the Jember Regency KPU and can implement SPIP on an ongoing basis. The type of research used is qualitative research using a phenomenological study approach, because the author wants to describe the implementation of SPIP in Jember Regency KPU.
Explainable and Interpretable Anomaly Detection Models for Production Data
Authors: Alharbi Basma , Liang Zhenwen , Aljindan Jana M. , Agnia Ammar K. , Zhang Xiangliang 
Published: November 2021

SummaryTrusting a machine-learning model is a critical factor that will speed the spread of the fourth industrial revolution. Trust can be achieved by understanding how a model is making decisions. For white-box models, it is easy to “see” the model and examine its prediction. For black-box models, the explanation of the decision process is not straightforward. In this work, we compare the performance of several white- and black-box models on two production data sets in an anomaly detection task. The presence of anomalies in production data can significantly influence business decisions and misrepresent the results of the analysis, if not identified. Therefore, identifying anomalies is a crucial and necessary step to maintain safety and ensure that the wells perform at full capacity. To achieve this, we compare the performance of K-nearest neighbor (KNN), logistic regression (Logit), support vector machines (SVMs), decision tree (DT), random forest (RF), and rule fit classifier (RFC). F1 and complexity are the two main metrics used to compare the prediction performance and interpretability of these models. In one data set, RFC outperformed the remaining models in both F1 and complexity, where F1 = 0.92, and complexity = 0.5. In the second data set, RF outperformed the rest in prediction performance with F1 = 0.84, yet it had the lowest complexity metric (0.04). We further analyzed the best performing models by explaining their predictions using local interpretable model-agnostic explanations, which provide justification for decisions made for each instance. Additionally, we evaluated the global rules learned from white-box models. Local and global analysis enable decision makers to understand how and why models are making certain decisions, which in turn allows trusting the models.
Bone Regeneration in Rat Using a PCL/gelatin/Nanoclay Nanocomposite Scaffold Containing Silybin
Authors: Tayeed Mohammad Hossein , Tehranchi Maryam , Ehterami Arian , Shanei Fereshteh , Taleghani Ferial , Semyari Hasan , ganji Saeed Mahdipour , Mehrnia Nika , Bozorgzadeh Shaghayegh , salehi majid 
Published: November 2021

Abstract
Bone cells need solid structures like the extracellular matrix (ECM) for healing injured areas. Finding appropriate materials and fabrication processes for the scaffold is a challenge in tissue engineering. In this study, 3-D porous scaffold was made of Polycaprolactone/Gelatin/Nanoclay (PCL/GNF/NC) and different dosages of silybin (Sil) were loaded by a combination of electrospinning and thermal-induced phase separation (TIPS) techniques. Different experiments like assessing surface morphology, porosity, compressive strength, water contact angle, degradation rate, releasing profile, hemolysis, and cell proliferation were done to assess attributes of fabricated scaffolds. For in vivo evaluation, the calvaria defect model in rats was used and the result was evaluated by histological analysis. Based on the results, the porosity of scaffolds was in the range of 70-90%, and samples containing silybin had lower compress strength and contact angle and higher degradation rate in comparison with samples without silybin. The results showed that PCL/GNF/NC/Sil1% had better cell proliferation bone healing than other studied groups. The results of this study can be considered for further researches to assess the effect of silybin in bone defect treatment.
Young Parents’ Experiences of Pregnancy and Parenting During the COVID-19 Pandemic: A Qualitative Study in the United Kingdom
Authors: Moltrecht Bettina , Dalton Louise J. , Hanna Jeffrey R. , Law Clare , Rapa Elizabeth 
Published: November 2021

Abstract
Young parents (aged 16-24 years) in the perinatal period are at an increased risk of poor mental health especially during the COVID-19 pandemic, due to multiple risk factors including social and economic instability. COVID-19 related restrictions had profound implications for the delivery of perinatal care services and other support structures for young parents. Investigating young parents’ experiences during the pandemic, including their perceived challenges and needs, is important to inform good practice and provide appropriate support for young parents. Qualitative interviews were conducted with young parents (n=21) during the COVID-19 pandemic in the United Kingdom from February – May 2021. Data were analysed using thematic analysis. Three key themes were identified to describe parents’ experiences during the COVID-19 pandemic. Parents reported specific COVID-19 related anxieties and stressors, including worries around contracting the virus and increased feelings of distress due to uncertainty created by the implications of the pandemic. Parents described feeling alone both at home and during antenatal appointments and highlighted the absence of social support as a major area of concern. Also, parents felt their perinatal care had been disrupted by the pandemic and experienced difficulties accessing care online or over the phone. This study highlights the potential impact of the COVID-19 pandemic on young parents, including their mental wellbeing and the perinatal support they were able to access. Insights from this study can inform the support and services offered to families going forward. Specifically, the findings emphasise the importance of (a) supporting both parents during perinatal appointments, (b) providing parents with mental health support early on and (c) finding ways to facilitate communication pathways between professionals and parents.
Comparative proteomics analysis provides new insights into the haustorium development of Taxillus chinensis (DC.) Danser
Authors: Pan Limei , Wan Lingyun , Song Lisha , He Lili , Jiang Ni , Long Hairong , Huo Juan , Ji Xiaowen , Hu Fengyun , Fu Jine , Wei Shugen 
Published: November 2021

Abstract
Background

Loranthus (Taxillus chinensis) is an important medicinal and parasitic plant that attacks other plants for living. To reveal the mechanisms of haustorium development, we employed an iTRAQ proteomics-based approach to identify differentially abundant proteins (DAPs) of fresh seeds (CK), baby (FB), and adult haustoria (FD).
Results

A total of 563 and 785 DAPs were successfully quantified in the early/later developmental stage, respectively. Pathway enrichment analysis indicated that the DAPs mainly associated with metabolic pathways, ribosome, phenylpropanoid biosynthesis and photosynthesis. In the meantime, DAPs associated with phytohormone signaling pathway changed markedly. Furthermore, we evaluated the contents change of phytohormone during the haustoria development. These results indicated that phytohormone is very important for haustorium development. qRT-PCR validation showed that the mRNA expression levels were consistent with the protein variation, suggesting that our result were reliable.
Conclusions

To the best of our knowledge, this is the first haustoria proteomes of loranthus, and our findings will improve our understanding of the molecular mechanism of haustoria development.
Individual and Environmental Risk Factors for COVID- 19 Mortality in Elderly
Authors: Bourdrel Thomas , Zabrocki Leo , Compte Nathalie , Bravenboer Bert , Decours Romain , Pelerin Hélène , De decker Laure , Kergaradec Laurence Le Jumeau , Lilamand Matthieu , Baudron Claire Roubaud , Fougère Bertrand , Mahmoudi Rachid , Schorr Benoit , Kaltenbach Georges , Vogel Thomas , Puech Vincent-Henri , Blanc Fréderic , Bind Marie-Abèle 
Published: November 2021

Abstract
Several studies have already explored individual and environmental risk factors for COVID-19 morality, however most study populations consisted of the overall population and mainly from China or the US. Our study focused on COVID-19 mortality in the elderly in seven European cities. Long-term exposure to air pollution was estimated through annual pollutant concentrations at the residential address averaged over the last two years of the study period between February and May 2020. We focused on the main outdoor air pollutants PM10, PM2.5, NO2 and O3. Short-term variations in air pollutants and weather parameters (e.g. temperature, UV, relative humidity) were also examined through a 20-day period before the confirmed PCR diagnostic of COVID-19. Individual risk factors such as smoking status, sex, body mass index (BMI), ischemic heart disease, diabetes, hypertension, chronic renal failure, history of cancer, COPD, and lung fibrosis, were taken into account. We found positive associations for diabetes and COVID-19 mortality (OR 2.2 CI 95% :1.1, 4.4). Using a multivariate logistic regression model adjusted for all patient characteristics and city, we fail to reject the null hypothesis of no association between COVID-19 mortality and long-term and short-term increase in PM2.5, PM10, NO2 and O3. Our study suffers from the fact that patient profiles strongly differ between high-polluted and less-polluted cities. Strong differences in COVID-19 mortalities were observed between cities, which could be due to differences in COVID-19 management and treatment, such as accessibility to reanimation and intensive units between cities. Overall, our study highlights the need to improve estimation of individual exposure to air pollution. Indeed, even with the high-efficiency modelisation systems used in our study, we were unable to estimate the effect of air pollution within each city, because variations in air pollution exposure were too small. Individual markers of air pollution exposure such as recently demonstrated with urinary black carbon or passive individual samplers, would be most suitable for future explorations. Concerning weather parameters, although previous studies concluded that increase in temperature and UV index could decrease COVID-19 morality, our data did not allow us to reject the null hypotheses.
A Clinical Observational Study of Effectiveness of a Solid Coupling Medium in Extracorporeal Shock Wave Lithotripsy
Authors: Chang Hao-Han , Lin Yu-Chih , Li Ching-Chia , Wu Wen-Jeng , Liou Wen-Chin , Lin Yusen Eason , Chen Wei-Chuan 
Published: November 2021

Abstract
This study aimed to investigate clinical effectiveness of stone disintegration by using isolation coupling pad(“icPad”) as coupling medium to reduce trapped air pockets during extracorporeal shock wave lithotripsy (ESWL). Patients underwent ESWL between Oct. 2017 to May. 2018 were enrolled in this clinical observational study. An electromagnetic lithotripter (Dornier MedTech Europe GmbH Co., Germany) was used in this study. Patients were divided into icPad group P1, P2 and semi-gel group C by different coupling medium. The energy level and total number of shock wave (SW) for group P1 and C was set at level 2 and 3000 and group P2 at level 3 and 2500. The successful stone disintegration rate (SSDR) was determined to evaluate the treatment outcome. All patients were evaluated by KUB film and ultrasonography after 90 days. Complications during ESWL were recorded. A total of 300 patients satisfied the inclusion criteria. There were no significant differences in characteristics of patients and stone among three groups. The corresponding SSDRs for patients in group P1, P2 and C was 73.0%, 73.2% and 55.3%, respectively. The SSDR in group P1 was statistically higher than Group C. Comparing to semi-liquid gel, coupling medium using by icPad could achieve better treatment outcome of stone disintegration in ESWL.
Ceramide synthesis regulates biogenesis and packaging of exosomal MALAT1 from adipose derived stem cells, increases dermal fibroblast migration and mitochondrial function.
Authors: Kong Xiaoyuan , Patel Niketa A. , Chalfant Charles E. , Cooper Denise R. 
Published: November 2021

Abstract
Background
The function of exosomes, small extracellular vesicles (EVs) secreted from human adipose-derived stem cells (ADSC), is becoming increasingly recognized as a means of transferring the regenerative power of stem cells to injured cells in wound healing. Exosomes are rich in ceramides and long noncoding RNA (lncRNA) like metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). We identified putative ceramide responsive cis-elements (CRCE) in MALAT1. We hypothesized that CRCE respond to cellular ceramide levels to regulate EVs MALAT1 packaging. MALAT1 levels by many cells exceeds those of protein coding genes and it’s expression is equally high in exosomes. Ceramide also regulates exosome synthesis, however, the contents of exosome cargo via sphingomyelinase and ceramide synthase pathways has not been demonstrated.
Methods
ADSC were treated with an inhibitor of sphingomyelinase, GW4869, and stimulators of ceramide synthesis, C2- and C6-short chain ceramides, prior to collection of conditioned media (CM). EV were isolated from CM, and then used to treat human dermal fibroblast (HDF) cultures in cell migration scratch assays, and mitochondrial stress tests to evaluate oxygen consumption rates (OCR).
Results
Inhibition of sphingomyelinase by treatment of ADSC with GW4869 lowered levels of MALAT1 in small EVs. Stimulation of ceramide synthesis using C2- and C6- ceramides increased cellular, EVs levels of MALAT1. The functional role of EV MALAT1 was evaluated in HDF by applying EVs to HDF. Control EVs increased migration of HDF, and significantly increased ATP production, basal and maximal respiration OCR. EV from GW4869-treated ADSC inhibited cell migration and maximal respiration. However, EV from C2- and C6-treated cells, respectively, increased both functions but not significantly above control EV except for maximal respiration. EV were exosomes except when ADSC were treated with GW4869 and C6-ceramide, then they were larger and considered microvesicles.
Conclusions
Ceramide synthesis regulates MALAT1 EV content. Sphingomyelinase inhibition blocked MALAT1 from being secreted from ADSC EVs. Our report is consistent with those of MALAT1 increasing cell migration and mitochondrial MALAT1 altering maximal respiration in cells. Since MALAT1 is important for exosome function, it stands that increased exosomal MALAT1 should be beneficial for wound healing as shown with these assays.