bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher Acceleration/Ejection Time Ratio Predicts Impaired Outcome in Aortic Valve Stenosis
Authors: Einarsen Eigir , Cramariuc Dana , Bahlmann Edda , Midtbo Helga , Chambers John B. , Gerdts Eva 
Published: January 2021

Background:
Acceleration time (AT)/ejection time (ET) ratio is a marker of aortic valve stenosis (AS) severity and predicts outcome in moderate-severe AS.

Methods:

We explored the association of increased AT/ET ratio on prognosis in 1530 asymptomatic patients with presumably mild-moderate AS, normal ejection fraction, and without known diabetes or cardiovascular disease. Patients were part of the SEAS study (Simvastatin Ezetimibe Aortic Stenosis). Patients were grouped according to the optimal AT/ET ratio threshold to predict cardiovascular death and heart failure hospitalization. Low-gradient severe AS was identified as combined valve area ≤1.0 cm
2
and mean gradient <40 mm Hg. Outcome was assessed in Cox regression analyses, and results are reported as hazard ratio and 95% CI.

Results:
Higher AT/ET ratio was significantly associated with lower systolic blood pressure, lower left ventricular ejection fraction, lower stress-corrected midwall shortening, low flow, and with higher left ventricular mass and higher peak aortic jet velocity. AT/ET ratio ≥0.32 provided the optimal cutoff for predicting incident cardiovascular death and heart failure hospitalization in the total study sample. In patients with low-gradient severe AS, this threshold was >0.32. AT/ET ratio ≥0.32 had a 79% higher risk of cardiovascular death and heart failure hospitalization (hazard ratio, 1.79 [95% CI, 1.20–2.68]). In patients with low-gradient severe AS, AT/ET ratio >0.32 was associated with a 2-fold higher risk of cardiovascular death and heart failure hospitalization (hazard ratio, 2.15 [95% CI, 1.22–3.77]).

Conclusions:
In asymptomatic nonsevere AS and low-gradient severe AS, higher AT/ET ratio was associated with increased cardiovascular morbidity and mortality.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT00092677.
Identification of Phenotypic Lipidomic Signatures in Response to Long Chain n‐3 Polyunsaturated Fatty Acid Supplementation in Humans
Authors: Picklo Matthew , Vallée Marcotte Bastien , Bukowski Michael , de Toro‐Martín Juan , Rust Bret M. , Guénard Frédéric , Vohl Marie‐Claude 
Published: January 2021

Background
Supplementation with long chain n‐3 polyunsaturated fatty acids is used to reduce total circulating triacylglycerol (TAG) concentrations. However, in about 30% of people, supplementation with long chain n‐3 polyunsaturated fatty acids does not result in decreased plasma TAG. Lipidomic analysis may provide insight into this inter‐individual variability.

Methods

Lipidomic analyses using targeted, mass spectrometry were performed on plasma samples obtained from a clinical study in which participants were supplemented with 3 g/day of long chain n‐3 in the form of fish oil capsules over a 6‐week period. TAG species and cholesteryl esters (CE) were quantified for 130 participants pre‐ and post‐supplementation. Participants were segregated into 3 potential responder phenotypes: (1) positive responder (R
pos
; TAG decrease), (2) non‐responder (R
non
; lacking TAG change), and (3) negative responder (R
neg
; TAG increase) representing 67%, 18%, and 15% of the study participants, respectively. Separation of the 3 phenotypes was attributed to differential responses in TAG with 50 to 54 carbons with 1 to 4 desaturations. Elevated TAG with higher carbon number and desaturation were common to all phenotypes following supplementation. Using the TAG responder phenotype for grouping, decreases in total CE and specific CE occurred in the R
pos
phenotype versus the R
neg
phenotype with intermediate responses in the R
non
phenotype. CE 20:5, containing eicosapentaenoic acid (20:5n‐3), was elevated in all phenotypes. A classifier combining lipidomic and genomic features was built to discriminate triacylglycerol response phenotypes and reached a high predictive performance with a balanced accuracy of 75%.

Conclusions
These data identify lipidomic signatures, TAG and CE, associated with long chain n‐3 response p henotypes and identify a novel phenotype based upon CE changes.

Registration

URL:
https://www.ClinicalTrials.gov
; Unique Identifier: NCT01343342.
MRI network progression in mesial temporal lobe epilepsy related to
healthy brain architecture
Authors: Morgan Victoria L. , Johnson Graham W. , Cai Leon Y. , Landman Bennett A. , Schilling Kurt G. , Englot Dario J. , Rogers Baxter P. , Chang Catie 
Published: January 2021

Abstract
We measured MRI network progression in mesial temporal lobe epilepsy (mTLE) patients as a function of healthy brain architecture. Resting-state functional MRI and diffusion-weighted MRI were acquired in 40 unilateral mTLE patients and 70 healthy controls. Data were used to construct region-to-region functional connectivity, structural connectivity, and streamline length connectomes per subject. Three models of distance from the presumed seizure focus in the anterior hippocampus in the healthy brain were computed using the average connectome across controls. A fourth model was defined using regions of transmodal (higher cognitive function) to unimodal (perceptual) networks across a published functional gradient in the healthy brain. These models were used to test whether network progression in patients increased when distance from the anterior hippocampus or along a functional gradient in the healthy brain decreases. Results showed that alterations of structural and functional networks in mTLE occur in greater magnitude in regions of the brain closer to the seizure focus based on healthy brain topology, and decrease as distance from the focus increases over duration of disease. Overall, this work provides evidence that changes across the brain in focal epilepsy occur along healthy brain architecture.
The Virgin Mother Sarah: The Characterization of the Matriarch in Genesis Rabbah
Authors: Schwartz Rami 
Published: January 2021

Abstract
This article analyzes the portrayal of the matriarch Sarah in the fifth-century Palestinian rabbinic midrash Genesis Rabbah. The midrash not only dedicates a large number of derashot to the matriarch, but it repeatedly depicts her as a model of personal and religious excellence. In order to understand this development, I turn my attention to the portrayal of Sarah in the works of Origen of Alexandria. Continuing New Testament themes, Origen presents her as the spiritual mother of Christianity and a prefiguration of Jesus’ mother Mary. Various textual and thematic parallels help demonstrate that the rabbis were both aware of this rhetoric and responded to it. Based on this, I conclude that the rabbis used their portrayal of Sarah to combat the Christian appropriation of the matriarch on the one hand, and to establish her as a Jewish alternative to the Virgin Mary on the other.
Popular Luxury in Southeastern Europe in the Long Eighteenth Century: A Case-Study of Italian Ceramics and Ottoman Greek Clients
Authors: Yagou Artemis 
Published: January 2021

Abstract
In late eighteenth-century Ottoman Epirus (today northwestern Greece), novel and pleasurable objects expressed on a material level the rise of new mentalities. We discuss specifically the ceramic trefoil jugs with Greek verses manufactured in Pesaro, Italy, by the firm of Casali and Callegari and its successors. These wine jugs follow a pre-existing formal typology and bear painted decoration; their particularity is that they are also inscribed with verses written in Greek, as they were produced following commissions by merchants from Epirus. This region boasted centers of commerce, wealth, and education of an emerging middle class; the economic power of this rising Greek bourgeoisie was combined with deepening ties with Europe, intellectual growth, and the strengthening of a distinct identity. We argue that these jugs are examples of popular luxury and the commissioning individuals were knowledgeable and proactive consumers exhibiting a growing confidence and indeed a new awareness with political connotations.
“Turkish” Textiles in South-Eastern and East-Central Europe in the Early Modern Period: The Evidence of Transylvanian Customs Accounts
Authors: Pakucs-Willcocks Mária 
Published: January 2021

Abstract
This paper analyzes data from customs accounts in Transylvania from the middle of the sixteenth century to the end of the seventeenth on traffic in textiles and textile products from the Ottoman Empire. Cotton was known and commercialized in Transylvania from the fifteenth century; serial data will show that traffic in Ottoman cotton and silk textiles as well as in textile objects such as carpets grew considerably during the second half of the seventeenth century. Customs registers from that period also indicate that Poland and Hungary were destinations for Ottoman imports, but Transylvania was a consumer’s market for cotton textiles.
Menstrual Taboos: religious Practices that Violate Women’s Human Rights
Authors: Anthony Natalia 
Published: January 2021

Abstract
Some world religions consider menstruation a taboo and impose different restrictions on menstruating women. This article argues that menstrual prohibitions based on religious grounds present a unique threat to women’s human rights. Although it is acknowledged that freedom of religion is an important human right, it is contended that, when it comes to a natural biological process like menstruation, it is the rights of women that must prevail in the clash between women’s human rights and freedom of religion.
A Note Concerning the Dynamics of Government Bond Yields
Authors: Akram Tanweer 
Published: January 2021

Keynes argued that the central bank can influence the long-term interest rate on government bonds and the shape of the yield curve mainly through the short-term interest rate. Several recent empirical studies that examine the dynamics of government bond yields not only substantiate Keynes’s view that the long-term interest rate responds markedly to the short-term interest rate but also have relevance for macroeconomic theory and policy. This article relates Keynes’s discussions of money, the state theory of money, financial markets, investors’ expectations, uncertainty, and liquidity preference to the dynamics of government bond yields for countries with monetary sovereignty. Investors’ psychology, herding behavior in financial markets, and uncertainty about the future reinforce the effects of the short-term interest rate and the central bank’s monetary policy actions on the long-term interest rate. JEL classifications: E12; E40; E43; E50; E58; E60; F30; G10; G12; H62; H63
Recycling of Stoma Losses: A Good Practice for Neonates with High Output Stomas—Our Experience and Comparison with Literature
Authors: Bindi Edoardo , Molinaro Francesco , Ferrara Francesco , Fusi Giulia , Taddei Alessandra , Sica Marina , Negro Simona , Tomasini Barbara , Detti Rita , Ditta Simona , Messina Mario , Angotti Rossella 
Published: January 2021

Introduction: The recycling of proximal stoma losses is known as a good practice to manage patients with high output stoma. In our center, we introduced this practice about 10 years ago. We revised our series before and after recycling protocol and we reviewed the literature. Methods: This is a retrospective study. We included all neonates who underwent ileostomy between 2000 and 2019. They were divided into two groups, Group A and Group B, before and after the introduction of recycling of stoma losses. Demographic data were included. Outcomes evaluated to demonstrate the efficacy of stools recycling were: weight at the time of anastomosis and at discharge, length of total parenteral nutrition, and time (expressed in days) between anastomosis and passage of the stools. Data were analyzed using Student’s t-test. P values <.05 were considered significant. Results: A total of 85 patients (29 females, 56 males) were included—Group A: 20 (24%) (13 males/7 females); Group B: 65 (76%) (43 males/22 females); Group A: 12/enterocolitis, 5/meconium-related ileum (MRI), 3/single intestinal perforation; Group B: 45 enterocolitis, 10/MRI, 8/single intestinal perforation, 1/an ileal atresia, 1/meconial peritonitis. Outcome about weight at anastomosis and discharge and about time of canalization were significant. Conclusion: We believe that the recycling of stoma losses is a safe and effective practice in neonates with ileostomy. Our technique of recycling is simple and practical. The benefit/risk rate is certain, in our opinion, in favor of the benefits as showed from our data.
The Impact of a Recently Approved Automated Insulin Delivery System on Glycemic, Sleep, and Psychosocial Outcomes in Older Adults With Type 1 Diabetes: A Pilot Study
Authors: Bisio Alessandro , Gonder-Frederick Linda , McFadden Ryan , Cherñavvsky Daniel , Voelmle Mary , Pajewski Michael , Yu Pearl , Bonner Heather , Brown Sue A. 
Published: January 2021

Background: Older adults with type 1 diabetes (≥65 years) are often under-represented in clinical trials of automated insulin delivery (AID) systems. We sought to test the efficacy of a recently FDA-approved AID system in this population. Methods: Participants with type 1 diabetes used sensor-augmented pump (SAP) therapy for four weeks and then used an AID system (Control-IQ) for four weeks. In addition to glucose control variables, patient-reported outcomes (PRO) were assessed with questionnaires and sleep parameters were assessed by actigraphy. Results: Fifteen older adults (mean age 68.7 ± 3.3, HbA1c of 7.0 ± 0.8) completed the pilot trial. Glycemic outcomes improved during AID compared to SAP. During AID use, mean glucose was 146.0 mg/dL; mean percent time in range (TIR, 70-180 mg/dL) was 79.6%; median time below 70 mg/dL was 1.1%. The AID system was in use 92.6% ± 7.0% of the time. Compared to SAP, while participants were on AID the TIR increased significantly (+10%, P = .002) accompanied by a reduction in both time above 180 mg/dL (−6.9%, P = .005) and below 70 mg/dl (−0.4%, P = .053). Diabetes-related distress decreased significantly while using AID ( P = .028), but sleep parameters remained unchanged. Conclusions: Use of this AID system in older adults improved glycemic control with high scores in ease of use, trust, and usability. Participants reported an improvement in diabetes distress with AID use. There were no significant changes in sleep.
Ultrasound-Guided Injection of Dextrose Versus Corticosteroid in Chronic Plantar Fasciitis Management: A Randomized, Double-Blind Clinical Trial
Authors: Raissi Gholamreza , Arbabi Amin , Rafiei Maryam , Forogh Bijan , Babaei-Ghazani Arash , Khalifeh Soltani Shayesteh , Ahadi Tannaz 
Published: January 2021

Design Chronic plantar fasciitis (PF) is a common cause of chronic heel pain, with different conventional treatment options. In this randomized clinical trial, the effect of ultrasound-guided injection of dextrose versus corticosteroid in chronic PF was evaluated and compared. Methods A total of 44 patients suffering from chronic PF who visited the physical medicine and rehabilitation clinic were enrolled in the study. Two table-randomized groups were formed. They received an ultrasonography-guided, single injection of either 40 mg methylprednisolone or 20% dextrose. Numeric Rating Scale (NRS), Foot and Ankle Ability Measure questionnaire with 2 subscales, Activities of Daily Living (FAAM-A) and Sports (FAAM-S), along with ultrasonographic parameters were evaluated before and at 2 and 12 weeks after the injection. Results. A total of 40 participants completed the study. Both interventions significantly improved pain and function at 2 and 12 weeks postinjection. After 2 weeks, compared with the dextrose prolotherapy, the corticosteroid group had significantly lower daytime and morning NRS scores (2.55 vs 4.1, P = .012, and 2.75 vs 4.65, P = .004), higher FAAM-S (66.84 vs 54.19; P = .047), and lower plantar fascia thickness at insertion and 1 cm distal to the insertion zone (3.89 vs 4.29 mm, P = .004, and 3.13 vs 3.48 mm, P = .002), whereas FAAM-A was similar in both groups ( P = .219). After 12 weeks, all study variables were statistically similar between corticosteroid and dextrose prolotherapy groups. No injection-related side effects were recorded in either group. Conclusion Both methods are effective. Compared with dextrose prolotherapy, our results show that corticosteroid injection may have superior therapeutic effects early after injection, accompanied by a similar outcome at 12 weeks postinjection. Levels of Evidence: Level II
Heterozygous mutation SLFN14 K208N in mice mediates species-specific differences in platelet and erythroid lineage commitment
Authors: Stapley Rachel J. , Smith Christopher W. , Haining Elizabeth J. , Bacon Andrea , Lax Sian , Pisareva Vera P. , Pisarev Andrey V. , Watson Steve P. , Khan Abdullah O. , Morgan Neil V. 
Published: January 2021

Abstract
Schlafen 14 (SLFN14) has recently been identified as an endoribonuclease responsible for cleaving RNA to regulate and inhibit protein synthesis. Early studies revealed that members of the SLFN family are capable of altering lineage commitment during T-cell differentiation by using cell-cycle arrest as a means of translational control by RNase activity. SLFN14 has been reported as a novel gene causing an inherited macrothrombocytopenia and bleeding in human patients; however, the role of this endoribonuclease in megakaryopoiesis and thrombopoiesis remains unknown. To investigate this, we report a CRISPR knock-in mouse model of SLFN14 K208N homologous to the K219N mutation observed in our previous patient studies. We used hematological analysis, in vitro and in vivo studies of platelet and erythrocyte function, and analysis of spleen and bone marrow progenitors. Mice homozygous for this mutation do not survive to weaning age, whereas heterozygotes exhibit microcytic erythrocytosis, hemolytic anemia, splenomegaly, and abnormal thrombus formation, as revealed by intravital microscopy, although platelet function and morphology remain unchanged. We also show that there are differences in erythroid progenitors in the spleens and bone marrow of these mice, indicative of an upregulation of erythropoiesis. This SLFN14 mutation presents distinct species-specific phenotypes, with a platelet defect reported in humans and a severe microcytic erythrocytosis in mice. Thus, we conclude that SLFN14 is a key regulator in mammalian hematopoiesis and a species-specific mediator of platelet and erythroid lineage commitment.
The effect of ketogenic diets on neurogenesis and apoptosis in the dentate gyrus of the male rat hippocampus
Authors: Irfannuddin Irfannuddin , Sarahdeaz Siti Fazzaura Putri , Murti Krisna , Santoso Budi , Koibuchi Noriyuki 
Published: January 2021

AbstractKetogenic diets (KD) have become popular diet to lose weight. However, the effect of such diets on brain function has not yet been clarified. Thus, we aimed to study the effects of KD on the neurogenesis and apoptosis in the dentate gyrus by assessing the expression of Ki-67 and Caspase-3. Rats (n = 24) were divided into four groups: control (normal diet), ketogenic diet (KD), time-restricted diet (TRD), and the combination of high-fat and time-restricted diet (CD) groups. The expression of Ki-67 in the TRD and CD groups was higher compared to others (P < 0.05), whereas no such difference was observed in the KD group. The number of Capase-3-positive cells decreased significantly in the TRD group (P < 0.05), but such decrease was not observed in the CD group. These results indicate that, although KD could be effective in reducing the body weight, possible adverse effect in the brain cannot be ignored.
N-3-oxo-octanoyl-homoserine lactone-mediated priming of resistance to Pseudomonas syringae requires the salicylic acid signaling pathway in Arabidopsis thaliana
Authors: Liu Fang , Zhao Qian , Jia Zhenhua , Song Cong , Huang Yali , Ma Hong , Song Shuishan 
Published: January 2021

AbstractBackgroudMany Gram-negative bacteria useN-acyl-homoserine lactones (AHLs) to communicate each other and to coordinate their collective behaviors. Recently, accumulating evidence shows that host plants are able to sense and respond to bacterial AHLs. Once primed, plants are in an altered state that enables plant cells to more quickly and/or strongly respond to subsequent pathogen infection or abiotic stress.ResultsIn this study, we report that pretreatment withN-3-oxo-octanoyl-homoserine lactone (3OC8-HSL) confers resistance against the pathogenic bacteriumPseudomonas syringaepv.tomatoDC3000 (PstDC3000) in Arabidopsis. Pretreatment with 3OC8-HSL and subsequent pathogen invasion triggered an augmented burst of hydrogen peroxide, salicylic acid accumulation, and fortified expression of the pathogenesis-related genesPR1andPR5. UponPstDC3000 challenge, plants treated with 3OC8-HSL showed increased activities of defense-related enzymes including peroxidase, catalase, phenylalanine ammonialyase, and superoxide dismutase. In addition, the 3OC8-HSL-primed resistance toPstDC3000 in wild-type plants was impaired in plants expressing the bacterialNahGgene and in thenpr1mutant. Moreover, the expression levels of isochorismate synthases (ICS1), a critical salicylic acid biosynthesis enzyme, and two regulators of its expression,SARD1andCBP60g, were potentiated by 3OC8-HSL pretreatment followed by pathogen inoculation.ConclusionsOur data indicate that 3OC8-HSL primes the Arabidopsis defense response upon hemibiotrophic bacterial infection and that 3OC8-HSL-primed resistance is dependent on the SA signaling pathway. These findings may help establish a novel strategy for the control of plant disease.