bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Deep Adversarial Model for Segmentation Assisted COVID-19 Diagnosis Using CT Images
Authors: Yao Hai-yan , Wan Wang-gen , Li Xiang 
Published: December 2021

Abstract
The outbreak of coronavirus disease 2019(COVID-19) is spreading rapidly around the world, resulting in a global pandemic. Imaging techniques such as computed tomography (CT) play an essential role in the diagnosis and treatment of the disease since lung infection or pneumonia is a common complication. However, training a deep network to learn how to diagnose COVID-19 rapidly and accurately in CT images and segment the infected regions like a radiologist is challenging. Since the infectious area are difficult to distinguish, and manually annotation the segmentation results is time-consuming. To tackle these problems, we propose an efficient method based on a deep adversarial network to segment the infection regions automatically. Then the predicted segment results can assist the diagnosis network in identifying the COVID-19 samples from the CT images. On the other hand, a radiologist-like segmentation network provides detailed information of the infectious regions by separating areas of ground-glass, consolidation, and pleural effusion, respectively. Our method can accurately predict the COVID-19 infectious probability and provides lesion regions in CT images with limited training data. Additionally, we have established a public dataset for multitask learning. Extensive experiments on diagnoses and segmentation show superior performance over state-of-the-art methods.
Single Machine Scheduling Problems With Sequence-dependent Setup Times and Precedence Delays
Authors: Lin Shih-Wei , Ying Kuo-Ching 
Published: December 2021

Abstract
Sequence-dependent setup times (SDSTs) and delayed precedence (DP) occur commonly in various manufacturing settings. This study investigated the single machine scheduling problem with SDSTs and DP constraints arising in an amplifier assembly company. A mixed-integer linear programming model and a lean iterated greedy (LIG) algorithm is proposed to search for the best job sequence with minimum makespan. Based on the characteristic of delayed precedence constraints of the problem, the proposed LIG algorithm implements a straightforward but effective lean construction mechanism, which can keep the search process within the feasible solution space and quickly converge toward the (near-) global optimum. Computational results reveal that LIG significantly outperforms the state-of-the-art algorithm in terms of solution quality and computational efficiency. This study mainly contributes to providing a simple, effective, and efficient algorithm that can facilitate industrial applications and act as a new benchmark approach for future research.
Enhanced Conductance Response in Radio Frequency Scanning Tunnelling Microscopy
Authors: Wit Bareld , Vranik Radovan , Müllegger Stefan 
Published: December 2021

Abstract
Diverse spectroscopic methods operating at radio frequency depend on a reliable calibration to compensate for the frequency dependent damping of the transmission lines. Calibration may be impeded by the existence of a sensitive interdependence of two or more experimental parameters. Here, we show by combined scanning tunnelling microscopy measurements and numerical simulations how a frequency-dependent conductance response is affected by different DC conductance behaviour of the sample. Distinct and well-defined DC-conductance behaviour is provided by our experimental model systems, which include C60 molecules on Au(111), exhibiting electronic configurations distinct from the well-known dim and bright C60’s reported so far. We investigate specific combinations of sample electronic configuration, DC bias voltage, and radio frequency modulation amplitude. Variations of the modulation amplitude as small as only a few percent may result in systematic conductance deviations as large as one order of magnitude. We provide practical guidelines for calibrating respective measurements, which are relevant to RF spectroscopic measurements.
Assess The Diversity of Gut Microbiota Among Healthy Adults For Forensic Application
Authors: Wang Shuangshuang , Song Feng , Gu Haoyu , Shu Zhilong , Wei Xiaowen , Zhang Ke , Zhou Yuxiang , Jiang Lanrui , Wang Zefei , Li Jienan , Luo Haibo , Liang Weibo 
Published: December 2021

Abstract
Background: Human gut microbiota is individually unique that hints the microbiota in fecal traces left in the crime scene could act as a potential biomarker for forensic personal identification. Next-generation DNA sequencing and bioinformatic analysis of fecal samples are revolutionizing our insights into gut microbial communities. While the formation of the gut microbiota is known to be multifactorial, it is unclear whether these characteristics can be applied to forensic applications. Therefore, the gut microbiota of healthy adults with different traits in Chengdu was investigated in this study.Results: Based on the STAMP analysis of each study group, the difference in gut microbiota composition in male and female subjects was observed. The male group was characterized by taxa in the phylum Proteobacteria, while the female group was described by Synergistetes phylum. The gut bacterial community assembly mechanism was mainly affected by the deterministic process. In addition, gut microbiota composition showed meaningful discrimination in each of the BMI groups. At the phylum level, in male subjects, increased representative phyla were Patescibacteria (p<0.05) in the underweight group and Bacteroidetes (p<0.05) in the normal-weight group, while in the female group, the significantly different phyla were Bacteroidetes, Firmicutes, and Actinobacteria. At the genus level, 44 unique genera were found to be significantly distinct across BMI study groups. By Fisher’s Linear Discriminant Analysis based on 38 of 44 unique genera, 94.4% of original BMI grouped subjects were correctly classified.Conclusion: In conclusion, subjects with different individual characters have specific gut microbiota, and can be discriminated by bioinformatics methods, suggesting it is promising to apply gut microbiota to forensic personal identification.
The Interdecadal Variations and Causes of the Relationship Between Autumn Precipitation Anomalies in Eastern China and SSTA Over the Southeastern Tropical Indian Ocean
Authors: Huo Liwei , Guan Zhaoyong , Jin Dachao , Liu Xi , Wang Xudong , Xia Yang 
Published: December 2021

Abstract
Eastern China has a large population with rapid development of the economy, where is the important crop producing region. In this region, the spatial and temporal distribution of autumn rainfall in Eastern China is uneven, which has important societal impact. Using the NCEP–NCAR reanalysis and other observational datasets, it is found that the spatial distribution of the first EOF mode of autumn rainfall anomalies in eastern China is consistent across the region, with significant interannual variabilities. Pronounced interdecadal variations are presented in the relationship between autumn rainfall anomalies in eastern China and sea-surface temperature anomalies (SSTA) over the southeastern tropical Indian Ocean (SETIO). The interdecadal changes have been analyzed by considering two epochs: one during 1979-2004 and the other during 2005-2019. It shows weak and insignificant correlations between the autumn rainfall anomalies in eastern China and SSTA over SETIO during the first epoch. On the other hand, they are remarkable and positively correlated with each other during the second epoch. The inter-decadal changes of the above relationship are related to the warming of SST over SETIO during the second epoch. It causes stronger low-level convergence and ascending motion over SETIO, with the co-occurrence of enhanced western Pacific subtropical high and anomalous abundant moisture over eastern China carried by a low-level southerly anomaly originating from the South China Sea. Simultaneously, the local Hadley circulation over eastern China becomes weak, corresponding to the anomalous ascending motion. The collaboration of anomalous water vapour transport and ascending motion strengthens the connection between the SETIO SSTA and the autumn precipitation anomalies in eastern China, and vice versa. In the boreal autumn of 2019, entire eastern China suffered extreme drought. It suggests that this drought event in eastern China is strongly affected by the negative SSTA over SETIO, which is consistent with the statistical results.
Treatment of Gouty Arthritis is Associated With Restoring Gut Microbiota And Promoting Production of Short Chain Fatty Acids
Authors: Park Han-Ki , Lee Sang Jin 
Published: December 2021

Abstract
Introduction: Although factors initiating the inflammatory response to monosodium urate crystals have been identified, the role of the gut microbiota and their metabolites on gout remain unknown. This study aimed to investigate changes in both gut microbiota and short chain fatty acids (SCFAs) according to inflammatory states of gout in the same patients.Methods: This study enrolled 20 patients with gout in the acute state who had active joints and were followed-up until the recovery state with no active joints. Blood and fecal samples were simultaneously collected within 3 days for each disease state. The stool microbiome was analyzed using 16S rRNA sequencing, and serum SCFAs were measured by gas chromatography-mass spectrometry. Differences in gut microbiome and serum SCFAs were compared between the acute and recovery states.Results: Beta diversity of the microbiome was significantly different between the acute and recovery states in terms of weighted UniFrac distance. In the recovery state, Prevotellaceae (p = 0.006) and the genus Prevotella (p = 0.009) were significantly enriched, whereas Enterobacteriaceae (p = 0.019) and its derivative genus Shigella (p = 0.023) were significantly decreased compared to the acute state. Similarly, the levels of acetate was dramatically increased in the recovery state compared to the acute state (p < 0.010). Levels of propionate and butyrate tended to increase but without statistical significance.Conclusion: Substantial alterations of bacterial composition with promotion of SCFA formation (especially acetate) were found after treatment in patients with gouty arthritis.
Applying the Input-output Price Model to Identify Inflation Processes
Authors: Przybyliński Michał , Gorzałczyński Artur 
Published: December 2021

Abstract
We try to examine the potential of input-output price model to identify mechanisms of price formation and transmission. Contrary to previous research focused on overcoming the specific limitations of the model, we test its overall performance. In the presented study the historical values of the commonly used Consumer Price Index were decomposed according to the classic input-output price model for an open economy. A sequence of ex-post simulations under various assumptions was used to identify the sources of inflation. This study required the use of input – output tables in current and previous year’s prices. The proposed method of decomposition might be a starting point to create a framework for studying different aspects of inflation process.JEL: C67, E31, E37
An Elementary Proof to eγ log log n &gt; Ψ(n)/n for any n &gt; 30
Authors: Hernandez-Serna Eduin 
Published: December 2021

Abstract
Let Ƥ be the set of all primes, Ψ/(n) = nIIn∈Ƥ,p|n (1 + 1/Ƥ) be the Dedekind psi function, we unconditionally show that eγ log log n > Ψ(n)/n for any n > 30, where γ if Euler's constant.
The characteristics of weather-related wind load parameters and wind power quality over the Dabanchen strong gale area
Authors: Xin Yu , Liu Zonhui , He Qing 
Published: December 2021

Abstract
Analysis of data from cup and ultrasonic anemometers on a 100 m-tall wind mast in the Dabanchen Canyon reveals that the turbulence intensities, gust factors, and peak factors measured by cup anemometers tend to be severely undervalued compared to longitudinal values from an ultrasonic anemometer, and onsite three-dimensional measurement data are preferred for weather-related wind load calculation. This difference is related to the rotating responses of cup anemometers during wind speed acceleration or deceleration and the higher vertical fluctuation speeds driven by dynamic interactions with the sloped canyon terrain. The higher lateral turbulence is key consideration for determining wind turbine classes in Danbanchen strong wind area. The longitudinal gust and peak factors under wind speeds exceeding 25.0 m s−1 are comparable with those of typhoon-prone open, flat regions. The chances of high turbulence and unstable stratification convective processes are very high; thus, wind power collection efficiencies are not high. Except the longitudinal turbulence integral scale, China’s wind-resistance codes are not applicable due to occasional undesirable strong gales with extraordinary turbulence structures. The measured vertical power spectral density of fluctuating wind in the high-frequency domain cannot reflect the rapidly adapting features of the vast terrain under strong gales.
Timing is everything: Clinical courses of Hunter syndrome associated with age at initiation of therapy in a sibling pair
Authors: Grant Nathan , Sohn Young Bae , Ellinwood N. Matthew , Okenfuss Ericka , Mendelsohn Bryce A. , Lynch Leslie E. , Braunlin Elizabeth A. , Harmatz Paul R. , Eisengart Julie B. 
Published: December 2021

Abstract
Hunter syndrome, or mucopolysaccharidosis (MPS) II, is a rare lysosomal disorder characterized by progressive, multi-system disease. As most symptoms cannot be reversed once established, early detection and treatment prior to the onset of clinical symptoms are critical. However, it is difficult to identify affected individuals early in disease, and therefore the long-term outcomes of initiating treatment during this optimal time period are incompletely described. We report long-term clinical outcomes of treatment when initiated prior to obvious clinical signs by comparing the courses of two siblings with neuronopathic Hunter syndrome (c.1504T>G[p.W502G]), one who was diagnosed due to clinical disease (Sibling-O, age 3.7 years) and the other who was diagnosed before disease was evident (Sibling-Y, age 12 months), due to his older sibling’s findings. The brothers began enzyme replacement therapy within a month of diagnosis. Around the age of 5 years, Sibling-O had a cognitive measurement score in the impaired range of <55 (average range 85-115), whereas Sibling-Y at this age received a score of 91. Sibling-O has never achieved toilet training and needs direct assistance with toileting, dressing, and washing, while Sibling-Y is fully toilet-trained and requires less assistance with daily activities. Both siblings have demonstrated sensory-seeking behaviors, hyperactivity, impulsivity, and sleep difficulties; however, Sibling-O demonstrates physical behaviors that his brother does not, namely biting, pushing, and frequent elopement. Since the time of diagnosis, Sibling-O has experienced significant joint contractures and a steady deterioration in mobility leading to the need for an adaptive stroller at age 11, while Sibling-Y at age 10.5 could hike more than 6 miles without assistance. After nearly a decade of therapy, there were more severe and life-limiting disease manifestations for Sibling-O; data from caregiver interview indicated substantial differences in Quality of Life for the child and the family, dependent on timing of ERT. The findings from this sibling pair provide evidence of superior somatic and neurocognitive outcomes associated with presymptomatic treatment of Hunter syndrome, aligned with current considerations for newborn screening.
Influence of Zika Virus in mechanisms related of cytotoxicity, cell adhesion, apoptosis and inflammatory markers on glioblastoma cells
Authors: Marinowic Daniel , Viola Fabiana Spillari , Majolo Fernanda , Zanirati Gabriele Goulart , Azevedo Pamella Nunes , Zanatta Ângela , Plentz Ismael , Alcará Allan Marinho , Morrone Fernanda Bueno , Scheffel Thamiris Becker , Cappellari Angélica Regina , Roehe Paulo Michel , Varela Ana Paula Muterle , Machado Denise Cantarelli , Costa Jaderson Costa Da 
Published: December 2021

Abstract
Glioblastoma (GBM) is one of the most common brain tumors in adults. Despite the presence of available treatments, it remains one of the most lethal and difficult tumors to treat such that most patients die within two years. Studies reported that infection with Zika virus (ZIKV) causes inhibition of cell proliferation as well as induction of apoptosis; moreover, these manifestations show a predilection for developing neuronal cells. In the present study, two GBM cell lines U-138 and U-251 were infected with ZIKV at multiplicities of infection (MOI) 0.1, 0,01 and 0.001 and tested for cell viability, cell migration, cell adhesion, induction of apoptosis, interleukin levels, and cell surface markers (CD14 and CD73). Our study demonstrated that the ZIKV infection promotes loss of cell viability and increased apoptosis potential. It was not evidenced changes in cell migration, however, the two glioblastoma cell lines displayed increased the cell adhesion behavior. There was small increase in the IL-4 level in the U-251 cell line after exposure to ZIKV, with no change in relation to INF-γ levels. Furthermore, we observed an increase in the percentage of cells expressing the CD14 surface marker in both cell lines and increased CD73 expression in the U-251 cell line. Our results suggest that ZIKV may be associated with decrease of cell viability and increased CD73 expression, enhanced adherence, as well as increased apoptosis rates. Further investigations are required to explore the potential use of ZIKV in the treatment of GBM.
Psychometric Evaluation of the NORC Diagnostic Screen for Gambling Problems (NODS) for the Assessment of DSM-5 Gambling Disorder
Authors: Brazeau Brad W. , Hodgins David C. 
Published: December 2021

Abstract
The National Opinion Research Center (NORC) Diagnostic Screen for Gambling Problems (NODS) is one of the most used outcome measures in gambling intervention trials. However, a screen based on DSM-5 gambling disorder criteria has yet to be developed or validated since the DSM-5 release in 2013. This omission is possibly because the criteria for gambling disorder only underwent minor changes from DSM-IV to DSM-5: the diagnostic threshold was reduced from 5 to 4 criteria, and the illegal activity criterion was removed. Validation of a measure that captures these changes is still warranted. The current study examined the psychometric properties of an online self-report past-year adaptation of the NODS based on DSM-5 diagnostic criteria for gambling disorder. Additionally, the new NODS was evaluated for how well it identifies ICD-10 pathological gambling. A diverse sample of participants (N = 959) was crowdsourced via Amazon’s TurkPrime. Internal consistency and one-week test-retest reliability were good. High correlations (r = .74–.77) with other measures of gambling problem severity were observed in addition to moderate correlations (r = .21–.36) with related but distinct constructs (e.g., gambling expenditures, time spent gambling, other addictive behaviours). All nine of the DSM-5 criteria loaded positively on one principal component, which accounted for 40% of the variance. Classification accuracy (i.e., sensitivity, specificity, predictive power) was generally very good with respect to the PGSI and ICD-10 diagnostic criteria. Future validation studies are encouraged to establish a gold standard measurement of gambling problem severity.
Energy/Exergy Conversion Factors of Low-Enthalpy Geothermal Heat Plants
Authors: Francke Henning 
Published: December 2021

Abstract
From the system perspective, a geothermal heat plant is not only a source of heat, but, in case of liquid producing wells producing liquid brine, also a sink for relevant amounts of electricity, consumed mainly by the pump(s). This electricity demand is usually not given much attention, although being decisive for operation costs and offering chances for demand side management as a variable consumer. From the perspective of an integrated energy system, geothermal installations basically move energy from the electricity sector into the heat sector. So do electrical compression heat pumps, whose performance is rated by the COP, the ratio between useful heat and invested energy and useful heat, the COP. This study transfers the COP concept to geothermal sites, by defining and determining the energy conversion factor quantity (i.e. relative auxiliary energy or operating cost of heat provision expressed in electricity) for a selection of mostly German geothermal sites. Based on heterogenous data consisting of operational values for some sites and theoretical estimations for others, the calculated ε range from 12 to 116. In analogy, the concept is extended to the exergy conversion factor ζ, which is calculated to range from 1 to 36. A comparison with alternative heat provision technologies, such as heat pumps (COP ≤ 6) or simple electric heating (ε ≈ 1), quantifies the potential service geothermal plants can render to the grid by converting electrical energy into useful heat. This study aims at quantifying the potential benefit of geothermal plants on for the electric grid.
A new taxonomy was developed for overlap across ‘Overviews of systematic reviews’: a meta-research study of research waste
Authors: Lunny Carole , Zhang Jia He , Chen Alyssa , Neelakant Trish , Shinger Gavindeep , Stevens Adrienne , Tasnim Sara , Sadeghipouya Shadi , Adams Stephen , Zheng Yi Wen , Lin Lester , Yang Pei Hsuan , Dosanjh Manpreet , Ngsee Peter , Ellis Ursula , Shea Beverley J. , Reid Emma K. , Wright James M. 
Published: December 2021

Abstract
Background
Multiple ‘overviews of reviews’ conducted on the same topic (“overlapping overviews”) represent a waste of research resources and can confuse clinicians making decisions amongst competing treatments. We aimed to assess the frequency and characteristics of overlapping overviews.
Methods
MEDLINE, Epistemonikos and Cochrane Database of Systematic Reviews were searched for overviews that: synthesised reviews of health interventions and conducted systematic searches. Overlap was defined as: duplication of PICO eligibility criteria, and not reported as an update nor a replication. We categorized overview topics according to 22 WHO ICD-10 medical classifications, overviews as broad or narrow in scope, and overlap as identical, nearly identical, partial, or subsumed. Subsummation was defined as when broad overviews subsumed the populations, interventions and at least one outcome of another overview.
Results
Of 541 overviews included, 169 (31%) overlapped across similar PICO, fell within 13 WHO ICD-10 medical classifications, and 62 topics. 148/169 (88%) overlapping overviews were broad in scope. Fifteen overviews were classified as having nearly identical overlap (9%); 123 partial overlap (73%), and 31 subsumed (18%) others.
Conclusions
One third of overviews overlapped in content and a majority covered broad topic areas. A multiplicity of overviews on the same topic adds to the ongoing waste of research resources, time and effort across medical disciplines. Authors of overviews can use this study and the sample of overviews to identify gaps in the evidence for future analysis, and topics that are already studied which do not need to be duplicated.