bluuebunny/crossref_metadata_2025_split huggingface dataset:
KONSTITUSIONALITAS KEBIJAKAN NEW NORMAL DALAM PERLINDUNGAN HAK HIDUP WARGA NEGARA
Authors: Vanesa Hariyanto Ruth Crista 
Published: August 2021

<p align="center"><strong><em>Abstract</em></strong><strong></strong></p><p><em>This study aims to answer two problems: first, outlining the correlation of the Right to Life with Economic Rights in New Nornal Policy; and secondly, analyzing theConstitutionality of New Normal Policy</em>. <em>The policy created during the Covid-19 Pandemic not infrequently reaping contracdictions. Especially the last one echoed by the governments is the existence of a New Normal Policy which is actually considered unconstitutional because with this policy the government is felt to have ignored the right of Right to Life of citizen and priorited Economic Right. For this reason, this article uses natural law theory as a means of interpretation of two existing problems. In accordance with this, this acricle argues that the New Normal Policy is a constitutional policy because it is in accordance with the spirit of Article 28A UUD NRI 1945. </em></p><p><em>Keywords</em>: <em>Human Rights, New Normal, Public Policy, Constitutionalism</em><em>.</em></p><p align="center"><strong>Abstrak</strong></p><p>Penelitian ini bertujuan untuk menjawab dua permasalahan: pertama, menguraikan korelasi Hak untuk Hidup dengan Hak Ekonomi dalam Kebijakan Nornal Baru; dan kedua, menganalisis Konstitusionalitas Kebijakan Normal Baru. Kebijakan yang dibuat saat Pandemi Covid-19 tak jarang menuai kontradiksi. Terlebih yang terakhir digaungkan oleh pemerintah adalah adanya New Normal Policy yang justru dinilai inkonstitusional karena dengan kebijakan ini pemerintah dirasa telah mengabaikan hak atas Hak Hidup warga negara dan mengutamakan Hak Ekonomi. Untuk itulah, artikel ini menggunakan teori hukum kodrat sebagai alat interpretasi dari dua masalah yang ada. Sejalan dengan hal tersebut, acricle ini berpendapat bahwa New Normal Policy merupakan kebijakan konstitusional karena sesuai dengan semangat Pasal 28A UUD NRI 1945.</p><p>Kata Kunci: Hak Asasi Manusia, Normal Baru, Kebijakan Publik, Konstitusionalisme.</p>
Modeling of MoS2 Tunnel Field Effect Transistor in Verilog-A for VLSI Circuit Design
Authors: Khan Md Azmot Ullah , Adesina Naheem Olakunle , Xu Jian 
Published: August 2021

Abstract
This paper presents the design of an inverter, half adder, and ring oscillator using compact models of MoS2 channel-based tunnel field effect transistor (TFET). The TFET models (both n and p-type) are written in high-level hardware language Verilog-Analog (Verilog-A) following the analytical model of [1] and the output characteristics of the components are simulated in Cadence/Spectre software. The performance of the designed inverter (a basic building block of VLSI circuit) is analyzed by extracting its different parameters, such as transfer characteristics, power dissipation and consumption, delay, power delay product. The simulated outputs (sum & carry) obtained from the half adder circuit exactly match the truth table of the circuit. Moreover, our observation reveals that the ring oscillator can operate at a higher frequency with lower power consumption in comparison to the existing CMOS and GFET technologies. We have also reported an improvement to the limiting factor of ring oscillator performance i.e. phase noise at two different offset frequencies. With all the output characteristics obtained from the commercial software simulation, we expect our model to be applicable to a real-time low-power VLSI circuit.
Cost-Effectiveness Analysis of Genomic Profiling in Early Breast Cancer in Colombia
Authors: Rojas Leonardo , Rojas-Reyes María , Rosselli Diego , Cardona Andres F. 
Published: August 2021

Abstract
Background: In Colombia, the best strategy to establish indication for adjuvant chemotherapy in early breast cancer (EBC) remains unknown. This study aimed to identify the cost-effectiveness of various strategies to establish the necessity of adjuvant chemotherapy.Methods: This study used an adapted decision-analytic model to compare cost and outcomes of care that includes Oncotype DX™ (ODX) or Mammaprint™ (MMP) tests with routine care without ODX or MMP tests (adjuvant chemotherapy for all patients) over a 5-year time horizon from the perspective of the Colombian National Health System (NHS; payer). Data were obtained from published literature and clinical trial database. The study population comprised women with hormone-receptor-positive (HR+), HER2-negative, lymph-node-negative (LN0) EBC with high-risk clinical criteria for recurrence. The outcome measures were incremental cost-effectiveness ratio (ICER; 2019 United States dollar per quality-adjusted life-year [QALY] gained) and net monetary benefit (NMB).Results: ODX increases QALYs by 0.05 and MMP by 0.03 with savings of $2,445 and $570 compared with the standard strategy, respectively. ICER for ODX was −$41,857 and that for MMP was −$18,253 per QALY; NMB was $2,821 and $771, respectively. Both tests were cost-effective under the defined threshold. When the two tests were compared, ODX was more cost-effective than MMP. Sensitivity analysis revealed that with a threshold of 1 gross domestic product per capita, ODX will be cost-effective in 95.5% of the cases compared with 70.2% cases involving MMP. Probabilistic sensitivity analysis revealed that ODX was a consistently superior strategy.Conclusions: Genomic profiling using ODX or MMP tests to define the need of adjuvant chemotherapy treatment in patients with HR+ and HER2− EBC is a cost-effective strategy that allows Colombian NHS to maintain budget.
Comprehensive Genomic And Epigenomic Analyses on Transcriptomic Regulation In Stomach Adenocarcinoma
Authors: Chen Junxing , Liu Weinan , Du Jiabin , Wang Pengcheng , Wang Jintian , Ye kai 
Published: August 2021

Abstract
DNA copy number variations (CNVs) and alterations in methylation (MET)-induced transcriptomic dysregulation plays an important role in promoting heterogeneous Stomach adenocarcinoma (STAD) progression. However, the association between DNA MET and CNVs, and the effect of this association during cancer development remain unknown. Altogether 313 STAD specimens had been extracted to examine DNA MET and copy numbers, and to measure messenger RNA (mRNA) expression (EXP). According to our results, copy-number-correlated (CNVcor) genes were remarkably co-regulated with MET-correlated (METcor) ones. Additionally, CNVcor and METcor genes were carried out multi-omics integration, and 3 STAD prognostic subtypes had been identified and verified using the independent data. Typically, the subtype that had higher aggressiveness was found to be associated with reduced PIK3CA, ARID1A, SPECC1, ZFHX3, KMT2D, OBSCN, ZBTB20, FSIP2, RANBP2 and TTN mutation rates, as well as increased JPH3, PLCXD3, and KCNB1 expression. Our results suggested that above mentioned genes played vital parts during invasive STAD development. And results of this comprehensive analyses on transcriptomic regulation at genomic and epigenetic levels facilitate to understand STAD pathology at various points of view, and assist in developing the effective STAD treatment.
A Comprehensive Social Matrix Factorization with Social Regularization for Recommendation Based on Implicit Similarity by Fusing Trust Relationships and Social Tags
Authors: Chen Rui , Zhang Jianwei , Zhang Zhifeng , Chang Yan-Shuo , Gao Jingli , Li Pu , Liang Hui 
Published: August 2021

Abstract
Social relationships play an important role in improving the quality of recommender systems (RSs). A large number of experimental results show that social relationship-based recommendation methods alleviate the problems of data sparseness and cold start in RSs to some extent. However, since the social relationships between users are extremely sparse and complex, and it is difficult to obtain accurately user preference model, thus the performance of the recommendation system is affected by the existing social recommendation methods. In order to accurately model social relationships and improve recommendation quality, we use explicit social relationships such as user-item ratings, trust relationships and implicit social relationships such as social tags to mine potential interest preferences of users and propose an improved social recommendation method integrating trust relationship and social tags. The method map user features and item features to the shared feature space by using the above social relationship, respectively, and obtains user similarity and item similarity through potential feature vectors of users and items, and continuously trains them to obtain accurate similarity relationship to improve the recommendation performance. Experimental results demonstrate that our proposed approach achieves superior performance to the other social recommendation approaches.
Segmental Variability of Precipitation In The Mahanadi River Basin During 1901-2017
Authors: Sahu Ramgopal Tilakram , Verma Mani Kant , Ahmad Ishtiyaq 
Published: August 2021

Abstract
Eigen-based sequential spatial pattern analysis an application of PCA is presented here. The analysis examines the spatial distribution of precipitation over the Mahanadi river basin. The Spatial(S)-mode of sequential spatial pattern analysis with the application of Maximum loading value of rotated retained principal component (also referred to as Maximum loading value approach) to assess a gridded monthly rainfall data of resolution 0.25° x 0.25° having a record length of 117 years (1901-2017). The meteorological records have a sequential spatial field for Spatial and Temporal-mode, which can be used for recognizing the area for precipitation variability and regime. The identified patterns of the different timeslot segments were then analyzed for their dispersions of the annual precipitation observed at different station points using similarities and dissimilar characteristics of inter-cluster and between clusters respectively. Validation of the regionalized pattern for distinctness and a pairwise comparison of CDFs using the Kolmogorov-Smirnov ‘D’ statistic test.
ITGB2 Expression is Negatively Correlated with the Prognosis of Acute Myeloid Leukemia
Authors: Zhou Jianan , Chen Bobin , Li Pei 
Published: August 2021

Abstract
Objective: Acute myeloid leukemia (AML) is a clonal malignant hematological neoplasm with a poor prognosis and high heterogeneity. Many studies have been conducted on the diagnosis and treatment of AML, but the immune microenvironmental mechanisms underlying AML disease progression have not been fully elucidated. The aim of this study was to find the potential genes in tumor microenvironmental mechanisms underlying the initiation and progression of AML through relevant biological informatics analysis, and investigate the potential influence of the gene in tumor microenvironment (TME).Methods: AML samples of genes were retrieved from The Cancer Genome Atlas (TCGA) databases. The number of tumor-infiltrating immune cells (TIC) as well as immune and stromal components in AML cases was calculated using the ESTIMATE and CIBERSORT algorithms. Two methods, COX regression analysis and protein-protein interaction (PPI) network, were applied to obtain related genes, and the intersection of related genes was taken to obtain differentially expressed genes (DEGs). Gene Set Enrichment Analysis (GSEA) was used for explore the biological signaling pathway. CIBERSORT analysis for the proportion of TICs was performed to reveal that TICs which are related of the target gene.Results: Cross-tabulation analysis of univariate COX regression analysis and PPI network known the β2 integrin factor (ITGB2) as a major predictor of AML prognosis. High expression of ITGB2 was correlated with low survival of AML patients. GSEA revealed that the higher the ITGB2 gene expression, the more active the immune-related activity. CIBERSORT analysis of the TICs ratio revealed that 9 kinds of TICs were negatively correlated with the expression of ITGB2, including CD4 memory resting T cells, CD8 T cells, naive B cells, resting NK cells, Plasma cells, follicular helper T cells, resting Mast cells, Eosinophils and activated mast cells. Only monocytes were positively correlated with ITGB2 expression. These results provided further evidence that ITGB2 levels may determine the prognosis of AML patients by modulating the immune status of TME, which provides an additional suggestion for the treatment of AML.
A Comparison of The Clinical Characteristics Comprising Abdominal Wall Endometriosis of Various Types
Authors: Wu YuShi , Dai Yi , Zhang Junji , Li Xiaoyan , Shi Jinghua , Gu Zhiyue , Zhang Jing , Leng Jinhua 
Published: August 2021

Abstract
Purpose

To classify abdominal wall endometriosis (AWE) according to the invasive levels of tissue mass, and to compare the differences in clinical characteristics between different types of AWE.
Methods

In this study, we retrospectively analyzed the clinical data of 367 patients who had undergone resection of abdominal-wall endometriotic lesions at the Peking Union Medical College Hospital from January 2008 to December 2018, and we divided the patients into three types according to their deepest level of lesion invasion. Type I designated invasion of skin and subcutaneous tissue; type II, of fascia and rectus abdominis; and type III, of peritoneum. We classified, compared, and analyzed the general conditions, clinical manifestations, auxiliary examinations, surgical conditions, postoperative conditions, and recurrence status of patients.
Result

s Of the 367 patients, type I patients accounted for 13.62%, type II patients for 56.68%, and type III for 29.7%. With respect to group comparisons, we observed that as the location of the mass deepened, the rate of concurrent pelvic endometriosis increased (P = 0.007), recurrent AWE was augmented (P = 0.02), the size of the mass increased (P < 0.001), the rate of multiple lesions became elevated (P < 0.001), the rate of mesh implantation increased (P < 0.001), the length of postoperative hospital stay (P < 0.001) was lengthened, the number of postoperative fever cases (P = 0.006) increased, and the risk of drainage placement (P < 0.001) was enhanced. The 5-year cumulative recurrence rate was 3.3%, and there was no significant difference in the recurrence rate among various types of AWE.
Conclusion

Various types of AWE manifest different clinical characteristics, surgical options, associations with pelvic endometriosis, and postoperative conditions.
Burnout and Job Stress of Anaesthesiologists in The Tertiary-Class A Hospital Northwest China: A Questionnaire Survey
Authors: Yang Guang , Fu Xiaoli , He Miao , Qing Zhong , Dong Buhuai , Ye Jiumin 
Published: August 2021

Abstract
Background

Our purpose was to assess job stress and burnout among anaesthesiologists in The Tertiary-class A Hospital Northwest China.
Objectives

Analyzes the possible causes and adverse consequences of increased job stress and burnout of anaesthesiologists in this region and puts forward suggestions in combination with the current national policies.
Study Design:
Questionnaire survey.
Setting:

Data were collected in the Northwest China from February 2020 until April 2020.
Methods

We sent electronic questionnaires to all 1960–2017 practising anaesthesiologists of The Tertiary-class A Hospital Northwest China. Of those, 338 (67.6%) were returned and could be used for analysis. Burnout and job stress were assessed by using modified Maslach Burnout Inventory-Human Services Survey and Chinese Perceived Stress Scale, respectively.
Results

First, as for emotional exhaustion, the situations of anaesthesiologists with different working years and workload are different with statistical significance (P < 0.05); Second, as for depersonalization, the situations of anaesthesiologists with different age, professional title, working years, physical health status and workload are different(P < 0.05); Third, as for personal accomplishment, the situations of anaesthesiologists with different physical health status are different (P < 0.05); Finally, The regression results showed that the longer the fatigue working years and the worse the physical health of anaesthesiologists in Northwest China, the more likely these two factors were to cause burnout (P < 0.05), as for job stress, there was a negative correlation between job stress and physical health status (P < 0.05).
Conclusions

Burnout and high job pressure are common among anaesthesiologists in The Tertiary-class A Hospital in Northwest China. We should focus on the allocation of labor intensity, pay attention to the physical and mental health of employees, establish targeted incentive mechanism, and improve the system of promotion and income rises for grassroots doctors. This may be not only conducive to the quality of medical care for patients, but also conducive to the development of anaesthesiology in China.
Trial Registration:
ChiCTR2000031316. Date registered: Mar 27, 2020.
Gravity cells as a necessary link in string theory. The formula for the gravitational constant, the formula for the mass of the electron, the formula for the minimum distance of the gravitational interaction, the formula for the minimum distance of the Coulomb interaction. The coincidence of the results obtained by the formulas and the experimental data.
Authors: Chernov Andrey 
Published: August 2021

Abstract
In this study, a new concept is introduced into physics - gravitational cells. The gravitational cell hypothesis was organically integrated into string theory. As a result, using the Schwarzschild radius formula and the Coulomb formula, a gravitational formula in the region of black holes was obtained on the basis of two fundamental constants, and its exact value was determined. The value of the "usual" gravitational constant was also confirmed and the mass of the gravitational cell was obtained. The introduction of the gravitational cell hypothesis into string theory made it possible to apply Planck's constant to gravitational interaction. As a result, a formula for the energy of a gravitational quantum and a formula for the vibrational velocity of a gravitational string were obtained. On this basis, the formula for the mass of the electron was obtained and its value was calculated, which coincided with the experimental mass of the electron. According to the formula for the vibrational velocity of the gravitational string, the formula for the minimum distance of the gravitational interaction was obtained and this distance was calculated. This minimum distance of the gravitational interaction with absolute accuracy coincided with the known experimental data obtained when determining the Casimir effect (force). Another great scientific result is the determination by a new formula of the minimum distance of the onset of the action of Coulomb forces between electric charges and obtaining the minimum length of a standing electric wave between charges.
Level of Understanding of Eras Affects Practitioners’ Practice and Perception of Early Postoperative Resumption of Oral Intake: A Nationwide Survey
Authors: Huang Huizhen , Zhang Yuelun , Shen Le , Huang Yuguang 
Published: August 2021

Abstract
Background: Early postoperative resumption of oral intake is supposed to be safe and beneficial to patients recovery. However, practitioners still have great confusion and disagreement about postoperative resumption of oral intake. This is a nationwide survey to investigate the current status of clinical practice and practitioners’ attitude toward postoperative resumption of oral intake along with their level of understanding of the ERAS guidelines.Methods: An anonymous web-based survey questionnaire via mobile social platform was carried out in mainland China from December 11-20, 2020. The Wilcoxon signed rank test or chi-square test was used to compare the propensity of the resumption of oral intake.Results: Totally 5370 responses were received, and 89% of them were from anesthesiology departments. The nature of the responses from clinical practitioners was highly diverse, but each of the three surgery types showed unique patterns of ERAS implementation. The respondents were more conserved regarding the commencement of both fluid and solid diets after gastrointestinal (GI) and hepato-pancreato-biliary (HPB) surgery than after non-abdominal (NA) surgery. Most respondents agreed that early oral intake is beneficial to reduce postoperative complications improve bowel recovery and overall outcome. 55% respondents considered themselves to have a better understanding of ERAS and tended to initiate oral intake early for all three surgery types (P<0.001).Conclusions: The postoperative resumption of oral intake is highly variable among GI, HPB and NA surgeries. A better understanding of ERAS would encourage practitioners to commence oral intake resumption much earlier.
ChemRL-GEM: Geometry Enhanced Molecular Representation Learning for Property Prediction
Authors: Fang Xiaomin , Liu Lihang , Lei Jieqiong , He Donglong , Zhang Shanzhuo , Zhou Jingbo , Wang Fan , Wu Hua , Wang Haifeng 
Published: August 2021

Abstract
Effective molecular representation learning is of great importance to facilitate molecular property prediction, which is a fundamental task for the drug and material industry. Recent advances in graph neural networks (GNNs) have shown great promise in applying GNNs for molecular representation learning. Moreover, a few recent studies have also demonstrated successful applications of self-supervised learning methods to pre-train the GNNs to overcome the problem of insufficient labeled molecules. However, existing GNNs and pre-training strategies usually treat molecules as topological graph data without fully utilizing the molecular geometry information. Whereas, the three-dimensional (3D) spatial structure of a molecule, a.k.a molecular geometry, is one of the most critical factors for determining molecular physical, chemical, and biological properties. To this end, we propose a novel Geometry Enhanced Molecular representation learning method (GEM) for Chemical Representation Learning (ChemRL). At first, we design a geometry-based GNN architecture that simultaneously models atoms, bonds, and bond angles in a molecule. To be specific, we devised double graphs for a molecule: The first one encodes the atom-bond relations; The second one encodes bond-angle relations. Moreover, on top of the devised GNN architecture, we propose several novel geometry-level self-supervised learning strategies to learn spatial knowledge by utilizing the local and global molecular 3D structures. We compare ChemRL-GEM with various state-of-the-art (SOTA) baselines on different molecular benchmarks and exhibit that ChemRL-GEM can significantly outperform all baselines in both regression and classification tasks. For example, the experimental results show an overall improvement of 8.8% on average compared to SOTA baselines on the regression tasks, demonstrating the superiority of the proposed method.