bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptación y validación de un cuestionario para la caracterización de las prácticas evaluativas de los aprendizajes en educación superior PREVAPREDU
Authors: Cortés Ibarra Erika Fernanda , Martínez Clares Pilar 
Published: May 2021

El propósito general de este artículo es dar a conocer el proceso de adaptación y validación del instrumento de recolección de información del estudio Percepción de estudiantes y docentes sobre las prácticas evaluativas como competencia profesional del profesorado en tres títulos de la Universidad El Bosque, Bogotá, Colombia PREVAPREDU. En este sentido, la adaptación se realizó a partir del nivel de formación y del enfoque pedagógico. Luego, buscó determinar la validez de contenido, establecer la validez de constructo del instrumento y señalar la estabilidad y/o fiabilidad del mismo. Esta investigación se desarrolló bajo la orientación metodológica de un estudio mixto convergente según Creswell (2012), con alcance no experimental, descriptivo de corte transversal. Es necesario advertir que la recolección de la información se realizó en un solo momento por cada unidad de análisis. Se utilizaron dos estrategias: análisis de los datos, que se aplicaron a una muestra de la población y revisión del instrumento por once expertos, quienes debían valorarlo según su claridad, pertinencia, relevancia y exclusividad, en una escala de cuatro niveles, sobre los componentes que constituyen las bases conceptuales del instrumento a saber, concepción de evaluación del aprendizaje, características de la evaluación, actores del proceso evaluativo, contenido de la evaluación, momentos para la evaluación, procedimientos del proceso evaluativo, técnicas e instrumentos de evaluación, usos de la evaluación del aprendizaje y formas de retroalimentación y por último, competencias evaluativas. El Alpha de Cronbach fue de 0,860 en los docentes y 0,973 en los estudiantes, resultado óptimo para la consistencia interna; respecto a la validez de contenido el resultado que se obtuvo en la W de Kendall es de 0,654 para los docentes y de 0,785 para los estudiantes los dos valores indican que hay una tendencia general, de acuerdo en el criterio de los jueces; en cuanto a la validez de constructo se aplicó el análisis factorial exploratorio y el confirmatorio: en el exploratorio Kaiser Meyer Olkin (kmo) se obtuvo para docentes 0,714 y para estudiantes 0,923, valores cercanos a 1, considerados óptimos, el confirmatorio permitió la reubicación de los ítems en cada una de las dimensiones, mediante la matriz de componentes rotados, se excluyeron valores inferiores a 0,500 por no ser significativos. En esta medida, PREVAPREDU se piensa como un recurso adaptado y validado para dar una mirada de 360° grados a las prácticas evaluativas de los docentes en el ámbito de la educación superior.
Atención Conjunta y Desarrollo del Lenguaje Durante el Primer Año de Vida
Authors: Cano Villagrasa Alejandro , Ribes Sonia Signes 
Published: May 2021

La atención temprana se centra en el óptimo desarrollo del niño desde el nacimiento hasta el inicio escolar, enfocado en el entorno familiar y social, en los aspectos biopsicosociales. Por otro lado, la adquisición del lenguaje es un proceso complejo que ocurre de forma muy temprana, a pesar de ello es fundamental para el desarrollo humano en la esfera tanto personal como social. Es por eso que el objetivo que tiene el presente estudio es determinar e identificar la relación y el papel que juega la atención temprana en la correcta adquisición del lenguaje y la comunicación en niños de muy corta edad, utilizando diversas escalas: Early-Social-Communication Scales y el Inventario de Desarrollo Comunicativo MacArthur. Se estudia mediante la creación de un diseño cuasi-experimental longitudinal-transversal, con un solo grupo experimental de 30 niños citados y estudiados en dos etapas diferentes: a los 8 meses (30 sujetos) y a los 12 meses (30 sujetos). Los resultados indican que si aumentan diversos aspectos de la atención conjunta, algunos estadios pertenecientes al lenguaje también se verán incrementados o mejorados, estableciendo una relación positiva entre ambas. A lo largo del primer año de vida, estas competencias se ven incrementadas significativamente, preparando los cimientos para la correcta adquisición del lenguaje oral.
Seafloor Geodesy From Repeated Multibeam Bathymetric Surveys: Application to Seafloor Displacement Caused by the 2011 Tohoku-Oki Earthquake
Authors: Fujiwara Toshiya 
Published: May 2021

Repeated multibeam bathymetric surveys played an important role for understanding the distribution of coseismic seafloor displacement caused by the March 11, 2011 Mw 9.0 Tohoku-oki earthquake. After the earthquake, we collected bathymetric data along the same tracks obtained before the earthquake. The selected tracks were crossing the trench and extending from the landward to seaward trench slopes. We examined the seafloor displacement on the landward relative to the seaward by means of the difference in bathymetry before and after the earthquake. The multibeam bathymetric survey has the advantage of areal coverage. The repeated surveys clarified the areal distribution of the coseismic seafloor displacement. In the main rupture area, very large seafloor displacement was observed. Sharp bathymetric change at the trench axis provided solid evidence that the fault slip on the shallowest part of the megathrust reached the trench axis and peaked at the trench axis. The very large displacement is limited to the particular area. Smaller seafloor displacements were observed in the area tens of kilometers away from the main rupture area. We present methods and results of the repeated multibeam bathymetric surveys and an application to the seafloor displacement caused by the 2011 Tohoku-oki earthquake in the northern Japan Trench. Less than several meters in seafloor vertical displacements and less than 20 m in seafloor horizontal displacement were estimated in the northern Japan Trench. The estimated smaller displacements are comparable in magnitude to error of the seafloor displacement observation from our bathymetric survey. Nevertheless, three adjacent survey tracks showed coherent relative differences in seafloor elevation, which suggests the relative difference enables us to discuss the along-track variation in seafloor displacement in the area. However, our survey was affected by uncertainties of roll and pitch biases and sound velocity errors. Well-prepared repeated multibeam bathymetric survey for the purpose of seafloor geodesy could lead to a higher resolution and more accurate result. Repeated acquisition of high resolution and accuracy bathymetric data using state-of-the-art technology will be important to quantitative discussion of the seafloor displacements caused by even smaller magnitude earthquakes and tsunamis.
Changes in Organic Matter Deposition Can Impact Benthic Marine Meiofauna in Karst Subterranean Estuaries
Authors: Brankovits David , Little Shawna N. , Winkler Tyler S. , Tamalavage Anne E. , Mejía-Ortíz Luis M. , Maupin Christopher R. , Yáñez-Mendoza German , van Hengstum Peter J. 
Published: May 2021

Subsurface mixing of seawater and terrestrial-borne meteoric waters on carbonate landscapes creates karst subterranean estuaries, an area of the coastal aquifer with poorly understood carbon cycling, ecosystem functioning, and impact on submarine groundwater discharge. Caves in karst platforms facilitate water and material exchange between the marine and terrestrial environments, and their internal sedimentation patterns document long-term environmental change. Sediment records from a flooded coastal cave in Cozumel Island (Mexico) document decreasing terrestrial organic matter (OM) deposition within the karst subterranean estuary over the last ∼1,000 years, with older sediment likely exported out of the cave by intense storm events. While stable carbon isotopic values (δ13Corgranging from −22.5 to −27.1‰) and C:N ratios (ranging from 9.9 to 18.9) indicate that mangrove and other terrestrial detritus surrounding an inland sinkhole are the primarily sedimentary OM supply, an upcore decrease in bulk OM and enrichment of δ13Corgvalues are observed. These patterns suggest that a reduction in the local mangrove habitat decreased the terrestrial particulate OM input to the cave over time. The benthic foraminiferal community in basal core sediment have higher proportions of infaunal taxa (i.e.,Bolivina) andAmmonia, and assemblages shift to increased miliolids and less infaunal taxa at the core-top sediment. The combined results suggest that a decrease in terrestrial OM through time had a concomitant impact on benthic meiofaunal habitats, potentially by impacting dissolved oxygen availability at the microhabitat scale or resource partitioning by foraminifera. The evidence presented here indicates that landscape and watershed level changes can impact ecosystem functioning within adjacent subterranean estuaries.
Clinical Character of CASPR2 Autoimmune Encephalitis: A Multiple Center Retrospective Study
Authors: Qin Xiaoxiao , Yang Huajun , Zhu Fei , Wang Qun , Shan Wei 
Published: May 2021

ObjectiveTo examine the clinical characteristics of autoimmune encephalitis associated with the contactin-associated protein-2 (CASPR2) antibody.Materials and MethodsMedical records of all patients diagnosed with CASPR2 antibody-associated encephalitis were retrospectively analysed. Data regarding demographic features, neurological symptoms and signs, laboratory tests, imaging results, treatments, and prognosis were collected.ResultsA total of 25 patients aged from 3 to 79 years old were enrolled in this study, with a median age of 43. Eight of 25 (32%) were female, and 17 of 25 (68%) were male. The median age of symptom onset was 42 years old with the course of disease from onset to hospital admission ranging from 2 days to 6 months (median was 17 days). Six patients (6/25) had fever as an onset symptom. During the course of disease, cognitive disturbance was the most common symptom, which was observed in 17 patients (17/25) in total. Eight patients (8/25) met the criteria for limbic encephalitis. Epileptic seizure occurred in six of these eight patients. Four patients (4/25) were diagnosed as Morvan syndrome. All patients were positive for anti-CASPR2 antibody in the serum (1:10–1:300). In six patients, antibodies were detected both in the blood and CSF (1:32–1:100). White blood cell (WBC) counts in the CSF were elevated in eight patients (8/25). The concentration of proteins in CSF increased in 10 patients (ranging from 480 to 1,337.6 mg/dl), decreased in seven patients (ranging from 23.2 to 130.5 mg/dl) and remained at a normal range in the other eight patients (ranging from 150 to 450 mg/dl). Abnormal electroencephalogram (EEG) activities included slow background activity and epileptic patterns. Abnormal signals in the bilateral hippocampus were detected by magnetic resonance imaging (MRI) in three patients presenting cognitive disturbance. In one patient who had limbic encephalitis, increased metabolism of bilateral basal ganglia and the mesial temporal lobe was revealed by PET-CT. Eleven of 15 patients receiving immunotherapy experienced varying degrees of improvement. Relapse occurred in four of 25 patients (4/25) after 2 months.ConclusionCASPR-antibody-mediated autoimmune encephalitis is characterized by diverse clinical manifestations. The most prominent conclusion revealed by this retrospective analysis is the involvement of both central and peripheral nerve systems, as well as a lower relapse rate, a good response to immunotherapy, and favorable short-term prognosis after treatment was also demonstrated. Besides, additional work is necessary to evaluate the long-term prognosis.
Prognostic Significance of the Fission1/Parkin Ratio for Sepsis: A Prospective Cohort Study
Authors: Huang Wei , Wang Xiaoting , Zhang Hongmin , Wang Guangjian , Liu Dawei 
Published: May 2021

Introduction: Fission1 (Fis1) and parkin are key proteins related to mitochondrial fission and mitophagy, respectively. This study aimed to assess the prognostic value of the Fis1/parkin ratio as a biomarker in patients with sepsis.Methods: Consecutive patients with sepsis (n = 133) or simple infection (n = 24) were enrolled within 24 h of arrival at the intensive care unit (ICU). Serum levels of Fis1, parkin, mitofusin2 (Mfn2), and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) were measured by enzyme-linked immunosorbent assay (ELISA) upon ICU admission. Clinical parameters and standard laboratory test data were also collected. All patients received follow-up for at least 28 days.Results: Patients with sepsis presented with significantly decreased serum levels of parkin, Mfn2, and PGC-1α, but an increased serum Fis1 level and Fis1/parkin, Fis1/Mfn2, and Fis1/PGC-1α ratios at ICU admission. Relative to patients with simple infections, the ratios were remarkably elevated in septic patients—particularly septic shock patients. The area under the receiver operating characteristic (ROC) curve of the Fis1/parkin ratio was greater than that of Fis1, parkin, Mfn2, and PGC-1α levels as well as that of the Fis1/Mfn2 and Fis1/PGC-1α ratios for prediction of 28-day mortality due to sepsis. All of the ratios were significantly higher in non-survivors than survivors at the 28-day follow-up examination. Fis1/parkin ratio was found to be an independent predictor of 28-day mortality in patients with sepsis.Conclusions: The Fis1/parkin ratio is valuable for risk stratification in patients with sepsis and is associated with poor clinical outcomes for sepsis in the ICU.
Using Metabolomics to Differentiate Player Positions in Elite Male Basketball Games: A Pilot Study
Authors: Khoramipour Kayvan , Gaeini Abbas Ali , Shirzad Elham , Gilany Kambiz , Chamari Karim , Sandbakk Øyvind 
Published: May 2021

Purpose: The current study compared metabolic profiles and movement patterns between different player positions and explored relationships between indicators of internal and external loads during elite male basketball games.Methods: Five main players from 14 basketball teams (n = 70) were selected as subjects and defined as backcourt (positions 1–3) or frontcourt (positions 4–5) players. Video-based time motion analysis (VBTMA) was performed based on players’ individual maximal speeds. Movements were classified into high and low intensity running with and without ball, high and low intensity shuffling, static effort and jumps. Saliva samples were collected before and after 40-min basketball games with metabolomics data being analyzed by multivariate statistics. Independent t-tests were used to compare VBTMA.Results: Frequency, duration, and distance of high and low intensity running and -shuffling were higher in backcourt players, whereas static effort duration and frequency as well as jump frequency were higher in frontcourt players (all p ≤ 0.05). The levels of taurine, succinic acid, citric acid, pyruvate, glycerol, acetoacetic acid, acetone, and hypoxanthine were higher in backcourt players, while lactate, alanine, 3-methylhistidine were higher and methionine was lower in frontcourt players (all p &lt; 0.05). High intensity running with ball was significantly associated by acetylecholine, hopoxanthine, histidine, lactic acid and leucine in backcourt players (p &lt; 0.05).Conclusion: We demonstrate different metabolic profiles of backcourt and frontcourt players during elite male basketball games; while aerobic metabolic changes are more present in backcourt players, frontcourt players showed lager changes in anaerobic metabolic pathways due to more static movements.
CXCR2 May Serve as a Useful Index of Disease Activity in Interstitial Lung Disease Associated With Primary Sjögren’s Syndrome
Authors: Zhu Xiaofang , Lu Saisai , Zhu Lixia , Yu Mengjiao , Wei Tingting , Zhu Xiaochun , Chen Dan , Chen Chengshui 
Published: May 2021

Background: Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease characterized by typical autoantibody production and lymphocytic-mediated exocrine gland damage. Interstitial lung disease (ILD) is a common complication of pSS and can be associated with a poor prognosis. However, the pathogenesis of ILD in pSS is still unclear.Methods: In this study, we used RNA sequencing to investigate the gene-expression profile of the minor salivary glands (MSGs) from 36 patients with ILD-pSS and 128 patients with non-ILD-pSS.Results: In the remarkably enriched chemokine-mediated signaling pathway, C-X-C motif chemokine receptor 2 (CXCR2), a receptor for interleukin-8, which participates in the activation of neutrophils, was found to be significantly elevated in both MSG and plasma from pSS patients with vs. without ILD (p &lt; 0.001). Furthermore, the CXCR2 expression level in MSG and plasma was significantly associated with the diffusing capacity of the lungs for carbon monoxide, erythrocyte sedimentation rate, and EULAR Sjögren’s Syndrome disease Activity Index in ILD-pSS.Conclusion: Therefore, with its potential role in ILD progression in patients with pSS and its strong association with clinical manifestations of the disease, CXCR2 may serve as a useful index for disease activity in ILD associated with pSS.
Pridopidine for the Improvement of Motor Function in Patients With Huntington's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Chen Shujun , Liang Tianyu , Xue Tao , Xue Shouru , Xue Qun 
Published: May 2021

Background: Huntington's disease (HD) is a progressive neurodegenerative disorder. Generally, it is characterized by deficits in cognition, behavior, and movement. Recent studies have shown that pridopidine is a potential and effective drug candidate for the treatment of HD. In the present study, we performed a meta-analysis to evaluate the efficacy and safety of pridopidine in HD.Methods: The MEDLINE, EMBASE, CENTRAL, and Clinicaltrials.gov databases were searched for randomized controlled trials (RCTs) which had that evaluated pridopidine therapy in HD patients.Results: We pooled data from 1,119 patients across four RCTs. Patients in the pridopidine group had a significantly lower Unified Huntington's Disease Rating Scale (UHDRS)-modified Motor Score (mMS) (MD −0.79, 95% CI = −1.46 to −0.11, p = 0.02) than those in the placebo group. Additionally, no differences were observed in the UHDRS-Total Motor Score (TMS) (MD −0.91. 95% CI = −2.03 to 0.21, p = 0.11) or adverse events (RR 1.06, 95% CI = 0.96 to 1.16, p = 0.24) in the pridopidine and placebo groups. In the subgroup analysis, the short-term (≤12 weeks) and long-term (&gt;12 weeks) subgroups exhibited similar efficacy and safety with no statistical significance in TMS, mMS, or adverse events. However, TMS (MD −1.50, 95% CI = −2.87 to −0.12, p = 0.03) and mMS (MD −1.03, 95% CI = −1.87 to −0.19, p = 0.02) were observed to be improved significantly when the dosage of pridopidine ≥90 mg/day. Additionally, pridopidine (≥90 mg/day) increased total adverse events (RR 1.11, 95% CI = 1.00 to 1.22, p = 0.04) compared with placebo. On this basis, we analyzed the incidence of various adverse events when the dosage was ≥90 mg/day. Nonetheless, these results were within the acceptable threshold, although patients developed symptoms, such as nasopharyngitis and insomnia.Conclusion: Pridopidine improved mMS and had no statistical significance in association with TMS or adverse events. Pridopidine (≥90 mg/day) improved TMS and mMS but increased adverse events, such as nasopharyngitis and insomnia. More RCTs were expected to assess pridopidine in HD.
Cervicocephalic Spotty Calcium for the Prediction of Coronary Atherosclerosis in Patients With Acute Ischemic Stroke
Authors: Zheng Chong , Yan Shaozhen , Fu Fan , Zhao Cheng , Guo Daode , Wang Zhichao , Lu Jie 
Published: May 2021

Purpose: To investigate the characteristics of cervicocephalic spotty calcium (SC) and coronary atherosclerosis in patients with acute ischemic stroke (AIS) and to assess the predictive value of SC for coronary atherosclerosis using combined coronary and cervicocephalic CTA.Materials and Methods: Patients with AIS (n = 70) confirmed by brain MRI or CT and patients with asymptomatic carotid atherosclerosis (n = 58) confirmed by carotid ultrasonography were enrolled in our study. Subjects in both groups underwent combined coronary and cervicocephalic CTA. SC was used to evaluate cervicocephalic atherosclerosis. Coronary artery stenosis (CAS) ≥ 50% by segment and coronary artery calcium score (CACS) were used to evaluate coronary atherosclerosis. The SC frequency and the difference in coronary atherosclerosis between the two groups were compared, and the correlation between SC and coronary atherosclerosis was analyzed. Independent factors for CAS ≥ 50% were assessed via logistic regression analysis. Receiver operating characteristic curve analysis was performed to evaluate the added value of SC for predicting CAS ≥ 50%.Results: Both SC and the CACS were significantly higher in the Stroke group than in the Control group (total SC count: 6.83 ± 4.34 vs. 2.98 ± 2.87, P &lt; 0.05; CACS: 477.04 ± 798.01 vs. 136.31 ± 205.65, P &lt; 0.05). There were significant differences in the presence of CAS ≥ 50% (61.4 vs. 27.6%, P &lt; 0.001). SC and coronary atherosclerosis were significantly correlated for both the CACS and CAS ≥ 50% (r = 0.746 and 0.715, respectively; P &lt; 0.001). SC was an independent predictor for CAS ≥ 50%.Conclusion: SC correlates significantly with the CACS and could serve as an independent predictor of CAS ≥ 50% in patients with AIS, which suggests that combined cerebrovascular and cardiovascular assessments are of importance for such patients.
Clinical Review and Prognostic Analysis of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptor-Associated Encephalitis
Authors: Wang Kemo , Shi Yanting , Du Qianwen , Zhang Ran-ran , Wu Huaikuan , Qiao Shan , Liu Xuewu 
Published: May 2021

Purpose: Autoimmune encephalitis (AE) is a heterogeneous neurological autoimmune disorder associated with cognitive and psychiatric symptoms. It can be divided into several subtypes based on autoantibodies. Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis (AMPAR-E) is one of the recently discovered AE subtypes, usually manifesting limbic encephalitis and with a good prognosis. Considering AMPAR-E has been described for the first time, only a few cases with similar antibodies have been reported clinically. We aimed to clarify the clinical course and prognosis of the disease in the light of previous reports.Patients and Methods: We collected data on the diagnosis and treatment of six cases of AMPAR-E, diagnosed at the Qilu Hospital of Shandong University in the past 5 years. We retrospectively analyzed the clinical characteristics of the patients and performed a follow-up of the disease.Results: The patients often presented with limbic encephalitis, which sometimes coexisted with tumors. In addition, immunotherapy had a significant effect on the disease. The clinical outcome was related to factors such as the age of onset, timing of treatment, and presence of tumors.Conclusion: In conclusion, specific antibody tests should be performed as early as possible in suspected cases. Clinicians should actively administer immunotherapy and the management of the co-tumor. In addition, repeat antibody tests and image examinations following discharge from the hospital guide the maintenance protocol of immunotherapy.