bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment patterns in patients with age-related macular degeneration and diabetic macular edema: A real-world claims analysis in Dubai
Authors: Kozak Igor , Gurbaxani Avinash , Safar Ammar , Rao Prasan , Masalmeh Amal , Assaf Hazar , Farghaly Mohamed , Pathak Prathamesh , Natarajan Ashok , Saffar Insaf 
Published: July 2021

Objectives
To characterize the pattern of approved anti-vascular endothelial growth factor (VEGF) treatments among patients with neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) in the United Arab Emirates (UAE).

Method
This was a retrospective, nonrandomized, observational cohort analysis of the Dubai Real-world Claims Database with a 360-day follow-up period. Adult patients diagnosed with nAMD or DME treated with ranibizumab or aflibercept for the first time were included. The primary objective was to evaluate anti-VEGF treatment patterns with respect to the proportion of patients receiving ranibizumab and aflibercept for nAMD and DME separately.

Results
Of the 451 patients included in the final study cohort, 83.6% and 16.4% had a diagnosis of DME (ranibizumab: 48.5%; aflibercept: 51.5%) and nAMD (ranibizumab: 40.5%; aflibercept: 59.5%), respectively, at baseline. Treatment frequency of ranibizumab/aflibercept was similar for nAMD (mean: 2.4/2.9 injections; p = 0.2389) with fewer injections in the ranibizumab cohort for DME (mean: 1.9/2.5 injections; p = 0.0002). Most patients received ≤3 anti-VEGF injections during the 360-day follow-up period. The time between consecutive treatments was large (nAMD: 73.6 days/10.5 weeks; DME: 80.5 days/11.5 weeks). Approximately 10%–13.5% of patients switched their anti-VEGF therapy. Most patients (83.8%) had a diabetes diagnosis during the follow-up period.

Conclusions
This real-world study provides an initial understanding of anti-VEGF treatment patterns in patients with nAMD and DME in the UAE. Treatment frequency of the 2 anti-VEGF agents assessed was similar in both patient populations. Both treatments were infrequently administered with large dosing intervals.
On-admission SARS-CoV-2 RNAemia as a single potent predictive marker of critical condition development and mortality in COVID-19
Authors: Miki Shoji , Sasaki Hiroaki , Horiuchi Hiroshi , Miyata Nobuyuki , Yoshimura Yukihiro , Miyazaki Kazuhito , Matsumura Takayuki , Takahashi Yoshimasa , Suzuki Tadaki , Matano Tetsuro , Kawana-Tachikawa Ai , Tachikawa Natsuo 
Published: July 2021

Background
This study aimed to clarify how SARS-CoV-2 RNAemia is related to COVID-19 critical condition development and mortality in comparison with other predictive markers and scoring systems.

Methods
This is a retrospective cohort study conducted at Yokohama Municipal Citizen’s Hospital and National Institute of Infectious Diseases. We recruited adult patients with COVID-19 admitted between March 2020 and January 2021. We compared RNAemia with clinical status on admission including scoring systems such as the 4C Mortality, CURB-65, and A-DROP, as well as the Ct value of the nasopharyngeal PCR, in predicting COVID-19 mortality and critical condition development.

Results
Of the 92 recruited patients (median age, 58; interquartile range, 45–71 years), 14 (14.9%) had RNAemia. These patients had an older age (median, 68 years vs. 55.5 years; p = 0.011), higher values of lactated dehydrogenase (median, 381 U/L vs. 256.5 U/L, p < 0.001), C-reactive protein (median, 10.9 mg/dL vs. 3.8 mg/dL; p < 0.001), D-dimer (median, 2.07 μg/mL vs. 1.28 μg/mL; p = 0.015), lower values of lymphocyte (median, 802/μL vs. 1007/μL, p = 0.025) and Ct of the nasopharyngeal PCR assay (median, 20.59 vs. 25.54; p = 0.021) than those without RNAemia. Univariate analysis showed RNAemia was associated with mortality (odds ratio [OR], 18.75; 95% confidence interval [CI], 3.92–89.76; area under the receiver operating characteristic curve [AUC], 0.7851; p = 0.002) and critical condition (OR, 72.00; 95% CI, 12.98–399.29; AUC, 0.8198; p < 0.001). Plus, multivariate analysis also revealed the association of RNAemia with critical condition (adjusted OR, 125.71; 95% CI, 11.47–1377.32; p < 0.001).

Conclusion
On-admission SARS-CoV-2 RNAemia is a potent predictive marker of COVID-19 critical condition and mortality. The adjusted OR for critical condition was as high as 125.71.
One-year change in plasma volume and mortality in the Japanese general population: An observational cohort study
Authors: Otaki Yoichiro , Watanabe Tetsu , Konta Tsuneo , Watanabe Masafumi , Asahi Koichi , Yamagata Kunihiro , Fujimoto Shouichi , Tsuruya Kazuhiko , Narita Ichiei , Kasahara Masato , Shibagaki Yugo , Iseki Kunitoshi , Moriyama Toshiki , Kondo Masahide , Watanabe Tsuyoshi 
Published: July 2021

Background
Changes in plasma volume, a marker of plasma volume expansion and contraction, are gaining attention in the field of cardiovascular disease because of its role in the prevention and management of heart failure. However, it remains unknown whether a 1-year change in plasma volume is a risk factor for all-cause, cardiovascular, and non-cardiovascular mortality in the general population.

Methods and results
We used a nationwide database of 134,291 subjects (age 40–75 years) who participated in the annual “Specific Health Check and Guidance in Japan” check-up for 2 consecutive years between 2008 and 2011. A 1-year change in plasm volume was calculated using the Strauss–Davis-Rosenbaum formula. There were 220 cardiovascular deaths, 1,001 non-cardiovascular deaths including 718 cancer deaths, and 1,221 all-cause deaths during the follow-up period of 3.9 years. All subjects were divided into quintiles based on the 1-year change in plasma volume. Kaplan–Meier analysis demonstrated that the highest 5th quintile had the greatest risk among the five groups. Multivariate Cox proportional hazard regression analysis demonstrated that a 1-year change in plasma volume was an independent risk factor for all-cause, cardiovascular, non-cardiovascular, and cancer deaths. The addition of a 1-year change in plasma volume to cardiovascular risk factors significantly improved the C-statistic, net reclassification, and integrated discrimination indexes.

Conclusions
Here, we have demonstrated for the first time that a 1-year change in plasma volume could be an additional risk factor for all-cause, cardiovascular, and non-cardiovascular (mainly cancer) mortality in the general population.
Comparison of apolipoprotein B/A1 ratio, TC/HDL-C, and lipoprotein (a) for predicting outcomes after PCI
Authors: Jung Hae Won , Hong Seung-Pyo , Kim Kee-Sik 
Published: July 2021

Background and aimsThe Apo B/A1 ratio is a major factor that predicts future cardiovascular outcomes. However, it is unclear whether the apolipoprotein B (Apo B)/apolipoprotein A1 (Apo A1) is a better predictor of future outcome than the total cholesterol (TC)/HDL-C ratio or lipoprotein (a) (Lp (a)) after the percutaneous coronary intervention (PCI). Therefore, we performed this study to evaluate the impact of the Apo B/A1 ratio on the patients who achieved LDL-C below 70 mg/dL one year after PCI.MethodsWe included 448 PCI patients whose LDL-C levels were below 70 mg/dL at follow-up. The Apo B/A1 ratio, TC/HDL-C ratio, and Lp (a) levels were measured at the time of PCI and follow-up, and decreases in these parameters between baseline and follow-up were assessed as potential markers to predict major cardiovascular adverse events (MACEs).ResultsDuring a median follow-up period of 38.0 months, 115 MACEs were recorded. The tertile with the lowest decrease in the Apo B/A1 ratio (≤ 0.146) showed a lower MACE survival rate compared to the other tertiles. There were no differences in MACE survival rates for the TC/HDL-C ratio or Lp (a) levels.ConclusionsThe Apo B/A1 ratio had better predictive accuracy for clinical outcomes compared to the TC/HDL-C ratio and Lp (a) level. A lower decrease in the Apo B/A1 ratio may be a residual risk factor for MACEs in patients who have reached LDL-C levels below 70 mg/dL after PCI.
Pulse-on-demand laser operation from nanosecond to femtosecond pulses and its application for high-speed processing
Authors: Petelin Jaka , Černe Luka , Mur Jaka , Agrež Vid , Kočica Jernej Jan , Schille Joerg , Loeschner Udo , Petkovšek Rok 
Published: July 2021

Abstract
In this manuscript we present a true pulse-on-demand laser design concept using two different approaches. First, we present a fiber master oscillator power amplifier (MOPA) based quasi-continuous wave (CW) laser, working at high modulation bandwidths, for generation of nanosecond pulses. Second, we present a hybrid chirped pulse amplification (CPA)-based laser, combining a chirped-pulse fiber amplifier and an additional solid-state amplifier, for generation of femtosecond pulses. The pulse-on-demand operation is achieved without an external optical modulator/shutter at high-average powers and flexible repetition rates up to 40 MHz, using two variants of the approach for near-constant gain in the amplifier chain. The idler and marker seed sources are combined in the amplifier stages and separated at the out using either wavelength-based separation or second harmonic generation (SHG)-generation-based separation. The nanosecond laser source is further applied to high throughput processing of thin film materials. The laser is combined with a resonant scanner, using the intrinsic pulse-on-demand operation to compensate the scanner’s sinusoidal movement. We applied the setup to processing of indium tin oxide (ITO) and metallic films on flexible substrates.
Volitive Modalverben im Deutschen und im modernen Chinesisch
Authors: Zeng Zhen 
Published: July 2021

Abstract
This article deals with the semantic differences and similarities between the volitive modal verbs in German and modern Chinese. The research questions of the article are: How is the intentionality of volitive modal verbs located in modern Chinese? What are the differences in their location in German and in modern Chinese? The four Chinese modal verbs xiǎng 想, yào 要, kĕn 肯 and yuànyì 愿意 are contrasted with the German volitive modal verbs wollen and mögen by numerous examples from the CCL corpus (The Corpus of Center of Chinese Linguistics at the University of Peking) with a corresponding translation. In this way, it enables a deeper understanding of the volitive modal verbs in both languages. In this respect, the contribution can be helpful both for language teachers who teach Chinese as a foreign language and for researchers in the field of contrastive linguistics.
Biochemical characterization of eight Greek algae as candidate species for local seaweed cultivation
Authors: Trikka Fotini , Israel Pauline , Koukaras Konstantinos , Argiriou Anagnostis 
Published: July 2021

Abstract
Seaweeds cover a wide range of applications, e.g. as food supplements, in animal feed, as biofuels or as sources of bioactive compounds. The Greek coast in the East Mediterranean is rich in various seaweeds that remain unexploited because their chemical and nutritional content has not yet been characterized. In the present study, eight seaweeds belonging to the Rhodophyta, Ochrophyta (class Phaeophyceae) and Chlorophyta were biochemically characterized and evaluated as potential food sources. Total polyphenol content, antioxidant activity, fatty acids and elemental composition were measured. Acanthophora nayadiformis, Ceramium sp. (Rhodophyta), Codium fragile (Chlorophyta), Cystoseira foeniculacea and Gongolaria barbata (formerly Cystoseira barbata) (Ochrophyta, Phaeophyceae) had the highest phenolic content and strongest antioxidant activity. Both brown and red seaweeds were rich in minerals, with G. barbata, Dictyopteris polypodioides (formerly Dictyopteris membranacea) (Chlorophyta, Phaeophyceae) and A. nayadiformis being the richest in macro- and microelements. The low Na/K ratio in most seaweeds (0.03–3.49) and the high iron content of red and brown algae (1.01–52.40 mg 100 g−1 of wet tissue) make algal consumption an attractive option. Chlorophyta and Phaeophyceae had the lowest n-6/n-3 PUFA ratios, with α-linolenic acid being the most abundant n-3 PUFA. The green algae Codium fragile and Ulva lactuca had the highest oleic and docosahexaenoic acid content, respectively. Finally, Rhodophyta were the highest producers of eicosapentaenoic acid. The findings confirmed the nutritional value of all seaweeds, highlighting brown seaweeds Cystoseira foeniculacea, G. barbata, and D. polypodioides as potential sources for food supplements and candidate species for seaweed cultivation in Mediterranean coastal waters.
Zukunftshoffnung und Gegenwartsdeutung
Authors: Tilly Michael 
Published: July 2021

Zusammenfassung
In diesem Beitrag wird zunächst gezeigt, wie die hellenistisch-jüdische Geistesbewegung der Apokalyptik die prophetische Tradition neu interpretiert und damit die Voraussetzungen dessen geschaffen hat, was die ersten Christen unter Prophetie in Geschichte und Gegenwart verstanden. Auf dieser Grundlage werden prägnante Beispiele für apokalyptisch motivierte und prophetisch geprägte Existenzwahrnehmungen und Zukunftshoffnungen in verschiedenen Textsegmenten des Neuen Testaments (Paulusbriefe, Markusevangelium, Matthäusevangelium und Johannesoffenbarung) beleuchtet. Zu zeigen ist, dass das frühe Christentum die prophetischen Traditionen durchweg eschatologisch kontextualisieren und in kreativer Weise innovativ und aktualisierend deuten konnte.
Prädiktion und Prävention in der Onkologie am Beispiel Brustkrebs
Authors: Schmutzler Rita , Rhiem Kerstin , Tüchler Anja 
Published: July 2021

Zusammenfassung
Die Präzision der Risikoprädiktion nimmt immer weiter zu. Eine Herausforderung ist dabei, zu garantieren, dass alle Patientinnen und Patienten davon profitieren. Dazu gehört, die Verständlichkeit der Risikokommunikation zu verbessern und Einflussfaktoren auf die Risikoperzeption zu erfassen. Zusätzlich ist es notwendig, sich mit der ungleichen Inanspruchnahme vulnerabler Gruppen sowie mit ihren Folgen für Wissenschaft und Gesellschaft zu befassen.
From principles to practice: embedding clinical reasoning as a longitudinal curriculum theme in a medical school programme
Authors: Singh Mini , Collins Lisa , Farrington Rebecca , Jones Matthew , Thampy Harish , Watson Pippa , Warner Christian , Wilson Kurt , Grundy Jessica 
Published: July 2021

Abstract
There is consensus that clinical reasoning (CR) is crucial for increasing the value of diagnosis, medical decision-making and error reduction. These skills should be developed throughout medical education, starting with undergraduate study. International guidance provides principles for CR curricula but interventions to date, are short term in nature. In this report, we describe the creation of a longitudinal, spiral CR curriculum within a large UK medical school programme (2500 students). A working group drove systematic evidence-based reform of existing structures. We utilised recognised models for curriculum development and mapping, relating learning outcomes to competency frameworks. Application of multiple teaching methodologies, rooted in enquiry-based learning and reported in CR literature, encourage metacognition for information-processing and illness script development. Development of CR is emphasised with recurrent, progressive learning opportunities, each stage purposefully building upon previous experiences. Formative and summative assessment approaches to drive learning, encouraging students’ ability to apply and articulate CR, is constructed via Miller’s Prism of Clinical Competence. Implementation of pedagogy is contingent on faculty development. Whilst many clinicians practice sound CR, the ability to articulate it to students is often a novel skill. Engagement in faculty development was strengthened through cross-institutional recognition of teaching workload and flexibility of delivery. We report lessons learned from the implementation phase and plans for measuring impact.
The Physical Internet: A means towards achieving global logistics sustainability
Authors: Moshood Taofeeq D. , Sorooshian Shahryar 
Published: July 2021

Abstract
The supply chains that make up the distribution networks are becoming more diverse as companies respond to global markets’ rigorous demands. Today, the immediate need for sustainable growth is to design, manufacture, and deliver the right product to experience drastic improvements in the right place, at the right price, and at the right time. As a massively distributed, integrated logistics infrastructure, a new “Physical Internet” (PI) model has been implemented to make the existing logistics structures more scalable and sustainable. This article discusses resource control in the PI’s modern supply chain and logistics systems while addressing the potential disruptions between the hubs during the transfer of goods. This article attempts to establish how companies will benefit from introducing the PI to optimise their strategic supply chain. This article used ATLAS.ti 9 automated tool to save, classify, and evaluate the data for this analysis to review the literature systematically. For PI, an increasing number of plans, blueprints, and requirements have been established. Still, minimal models are currently developed, explaining how the transformation from the strengthened logistics business models to the PI could occur. There is a lack of awareness of the necessary market structures that can include crucial players and allow the PI model to be embraced. Therefore, this research brings a new viewpoint on logistic operations through the PI idea, guarantees the present situation’s view, and presents a solution to the society–business–technology framework.
Synthesis and characterization of different soybean oil-based polyols with fatty alcohol and aromatic alcohol
Authors: Yang Fukai , Yu Hao , Deng Yuyuan , Xu Xinyu 
Published: July 2021

Abstract
In this article, five kinds of soybean oil-based polyols (polyol-E, polyol-P, polyol-I, polyol-B, and polyol-M) were prepared by ring-opening the epoxy groups in epoxidized soybean oil (ESO) with ethyl alcohol, 1-pentanol, isoamyl alcohol, p-tert-butylphenol, and 4-methoxyphenol in the presence of tetrafluoroboric acid as the catalyst. The SOPs were characterized by FTIR, 1H NMR, GPC, viscosity, and hydroxyl numbers. Compared with ESO, the retention time of SOPs is shortened, indicating that the molecular weight of SOPs is increased. The structure of different monomers can significantly affect the hydroxyl numbers of SOPs. Due to the large steric hindrance of isoamyl alcohol, p-hydroxyanisole, and p-tert-butylphenol, SOPs prepared by these three monomers often undergo further dehydration to ether reactions, which consumes the hydroxyl of polyols, thus forming dimers and multimers; therefore, the hydroxyl numbers are much lower than polyol-E and polyol-P. The viscosity of polyol-E and polyol-P is much lower than that of polyol-I, polyol-B, and polyol-M. A longer distance between the molecules and the smaller intermolecular force makes the SOPs dehydrate to ether again. This generates dimer or polymers and makes the viscosity of these SOPs larger, and the molecular weight greatly increases.
“No One is Ever Ready for Something Like This.” – On the Dialectic of the Holocaust in First-Person Shooters as Exemplified by Wolfenstein: The New Order
Authors: Pfister Eugen , Zimmermann Felix 
Published: July 2021

Abstract
For almost three decades, the depiction of the Holocaust was considered taboo in digital games. While World War II became a popular historicizing setting for digital games, the crimes of the Nazi regime and the Holocaust in particular remained conspicuously absent. In this article we show that discussions about the fundamental suitability of specific media or media forms for dealing responsibly with the memory of the Nazi regime’s crimes have already taken place several times and that similar arguments can now be applied to the digital game. With this in mind, we pursue the question of whether only so-called serious games are suitable for this purpose, or whether, on the contrary, mainstream blockbuster games – here specifically the first-person shooter Wolfenstein: The New Order – can find ways to maintain the memory of the Holocaust without trivializing it. We approach this question by analyzing chapter 8 of Wolfenstein: The New Order, in which protagonist William “B.J.” Blazkowicz allows himself to be deported to a Nazi concentration camp. We discuss this camp scene dialectically, on the one hand, as an encouragement to rethink the first-person shooter and, on the other hand, as a reproduction of a superficial iconography of the Holocaust.
U.S. medical school admissions and enrollment practices: status of LGBTQ inclusivity
Authors: Gamble Reid M. , Pregnall Andrew M. , Deng Angie , Ehrenfeld Jesse M. , Talley Jan 
Published: July 2021

Abstract

Context
The failure to collect information on lesbian, gay, bisexual, transgender, and queer (LGBTQ) identity in healthcare and medical education is a part of a systemic problem that limits academic medical institutions’ ability to address LGBTQ health disparities.

Objectives
To determine whether accurate sexual and gender minority (SGM) demographic data is being consistently collected for all US medical schools during admissions and enrollment, and whether differences exist between collection practices at osteopathic and allopathic schools.

Methods
Secure, confidential electronic were sent via email in July 2019 to 180 osteopathic (n=42) and allopathic (n=138) medical schools identified through the American Association of Colleges of Osteopathic Medicine Student Guide to Osteopathic Medical Colleges database and the American Association of Medical Colleges Medical School Admissions Requirements database. The nine question survey remained open through October 2019 and queried for; (1) the ability of students to self report SGM status during admissions and enrollment; and (2) availability of SGM specific resources and support services for students. Chi square analysis and the test for equality of proportions were performed.

Results
Seventy five of 180 (41.7%) programs responded to the survey; 74 provided at least partial data. Of the 75 respondent schools, 55 (73.3%) allowed applicants to self report a gender identity other than male or female, with 49 (87.5%) of those being allopathic schools compared with 6 (31.6%) osteopathic schools. Similarly, 15 (20.0%) allowed applicants to report sexual orientation, with 14 (25.5%) of those being allopathic schools compared with one (5.3%) osteopathic school. Fifty four of 74 (73.0%) programs allowed matriculants to self report a gender identity other than male or female; 11 of 74 (14.7%) allowed matriculants to report sexual orientation.

Conclusions
Demographics collection practices among American medical education programs that responded to our survey indicated that they undervalued sexual orientation and gender identity, with osteopathic programs being less likely than allopathic programs to report inclusive best practices in several areas. American medical education programs, and their supervising bodies, must update their practices with respect to the collection of sexual orientation and gender identity demographics as part of a holistic effort to address SGM health disparities.