bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolated central nervous system relapses in patients with high-risk neuroblastoma. Clinical presentation and prognosis: experience of the Polish Pediatric Solid Tumors Study Group.
Authors: Wieczorek Aleksandra , Stefanowicz Joanna , Hennig Marcin , Adamkiewicz-Drozynska Elzbieta , Stypinska Marzena , Dembowska-Baginska Bozenna , Gamrot Zuzanna , Woszczyk Mariola , Geisler Julia , Szczepanski Tomasz , Skoczen Szymon , Ussowicz Marek , Pogorzala Monika , Janczar Szymon , Balwierz Walentyna 
Published: November 2021

Abstract
Although isolated central nervous system (CNS) relapses are rare, they may become a serious clinical problem in intensively treated patients with high-risk neuroblastoma (NBL). The aim of the study is presentation, assessment of incidence and the clinical course of isolated CNS relapses. Retrospective analysis involved 848 NBL patients treated from 2001 to 2019 at 8 centers of the Polish Pediatric Solid Tumors Study Group (PPSTSG). Group characteristics at diagnosis, treatment and patterns of relapse were analyzed. Observation was completed in December 2020. We analyzed 286 high risk patients, including 16 infants. Isolated CNS relapse, defined as presence of a tumor in brain parenchyma or leptomeningeal involvement, was found in 13 patients (4.5%, 8.4% of all relapses), all of them were stage 4 at diagnosis. Isolated CNS relapses seem to be more common in young patients with stage 4 MYCN amplified NBL, and in this group they may occur early during the first line therapy. The only or the first one symptom may be bleeding into CNS, especially in younger children, even without clear relapse picture on imaging, or the relapse may be clinically asymptomatic and found on routine screening. Although incidence of isolated CNS relapses is not statistically significantly higher in patients after immunotherapy, their occurrence should be carefully monitored, especially in intensively treated infants, with potential disruption of brain-blood barrier.
Patient Mistreatment of Health Care Providers
Authors: Mahoney David A , Gopisetty Divya , Osterberg Lars , Nudel Matthew JR , Smith-Coggins Rebecca 
Published: November 2021

Abstract
BackgroundMistreatment of medical professionals by patients is an ongoing problem. We aimed to construct and evaluate a curriculum that would prepare medical professionals for mistreatment by patients. MethodsLessons learned from 15 interviews and 2 focus groups with medical professionals were distilled into a multi-modal curriculum including didactics, simulation videos and role-play scenarios aimed to improve confidence in addressing mistreatment. This curriculum was disseminated at five educational workshops to medical professionals of various training groups and experience levels. Pre- and post-surveys were distributed to assess changes in participant’s perspectives on readiness to address mistreatment. The signed-rank test was implemented to compare pre- and post- data. ResultsParticipants were more likely to agree post-workshop that they had the right words to say, had a plan for what to do, and were more willing to speak up when they themselves or someone else was mistreated (p < .001). They were also more likely to agree post-workshop that there was something they could do to address patient mistreatment (p < .001).ConclusionsParticipant familiarity and confidence in responding to patient mistreatment increased. Our curriculum may serve as a foundation for institutions seeking to equip their educators, providers, and trainees with strategies for addressing this important issue.
Frontal Neurenteric Cysts Combined with Anterior Skull Base Osteoma and Spontaneous Intracranial Pneumatosis：A Case Report and Literature Review
Authors: Wu Yuekui , Pan Xin , Yan Pengxiang , Zhang Yuqi , Sun Yanhui , Cui Jian 
Published: November 2021

Abstract
Background: Neurenteric cysts (NCs) are rarely that arise from incomplete dissolution of the neurenteric canal,most are found in the spinal canal, intracranial neurenteric cysts occur rarely,no cases of neurenteric cysts combined with anterior skull base osteoma have been reported.Case presentation: A 23-year-old man presented with intermittent headache and vomiting for more than 20 days after running.The computed tomography(CT) and magnetic resonance imaging(MRI) showed a cystic mass and bone tumor in the left frontal lobe, accompanied by intracranial pneumatosis in the left ventricle and left frontal lobe,then he underwent a bicoronal scalp incision and frontal craniotomy to perform resection of the lesion. Postoperative cranial MRI showed no residual tumor. The patient recovered well after surgery, without ambulation or neurological complications.Conclusions: Based on existing literature and this case, we suggest that surgical resection of intracranial neurenteric cysts should be the first choice, and the accompanying intracranial osteoma is removed at the same time. The treatment of choice remains complete surgical excision, and prognosis is good.
Prevention of Incisional Hernia in Ovarian Cancer Patients Undergoing Midline Laparotomy
Authors: Capdevila Berta Fabregó , Miralpeix Ester , Solé-Sedeño Josep-Maria , Pereira José-Antonio , Mancebo Gemma 
Published: November 2021

Abstract
BACKGROUND: Incisional hernias (IH) are a frequent complication of midline laparotomies in abdominal surgery. This study was conducted in order to determine the efficacy of mesh placement and assess the optimal fascia closure technique to reduce the IH rate in patients surgically treated after being diagnosed with malignant or borderline ovarian tumors.METHODS: Retrospective data from patients undergoing midline laparotomy for borderline or ovarian cancer in Hospital del Mar, Barcelona, from January 2008 to December 2019 were collected. Patient demographic, preoperative and intraoperative characteristics and risk factors for hernia were reported. The incidence of IH between groups (mesh and non-mesh) and the technique used in fascial closure for each patient (small bites technique vs large tissue bites) was reported. RESULTS: In total, 133 patients with available data for follow-up were included. After clinical and radiological examination, 25 (18.79%) of them showed IH. 18 of 61(29.5%) patients in non-mesh group developed IH, compared with 7 of 72 (9.7%) in mesh group (OR 0.25, 95% CI 0.09-0.66, p<0.005). Patients of large tissue bites group showed higher prevalence of IH compared with small bites technique group without statistical significance (OR 0.46, 95% CI 0.17-1.24, p=0.119). The combination of mesh reinforcement and small bites technique for fascial closure significantly reduce IH risk (p=0.021). CONCLUSION: Incidence of IH is high in patients undergoing midline laparotomy for ovarian cancer or borderline ovarian tumor. The addition of a prophylactic mesh and use of small bites technique may reduce the incidence of IH and potentially minimize the social impact and costs of this complication.
3d Printed Customized Total Scapular Replacement With Constrained Shoulder Joint After Wide Resection For Scapula Chondrosarcoma Treatment: A Case Report
Authors: Tran Dung Trung , Dang Quang Minh , Tran Thanh Duc , Nguyen Sang Tran Quang , Tran Cong Van 
Published: November 2021

Abstract
IntroductionTotal scapular replacement surgery with constrained reverse shoulder joint a complex surgery, especially in the selection of replacement materials. The advent of three-dimensional (3D) printing technique contribute significantly to the success of surgeryCase presentationA 62-year-old female patient discovered a scapular tumor at the end of 2017. She underwent curettage and bone graft surgery 3 times. The histopathological diagnosis was enchondroma. However, tumor recurrence and malignant transformation unfortunately presented later. She visited our center and total scapular replacement with constrained reverse shoulder joint was then performed. After 6 months, the patient's functional outcome was evaluated by using Musculoskeletal Tumour Society Score (MSTS) with a score of 26/30. There was no sign of local tumor recurrence. The functional of elbow and hand was preserved almost completely. The range of active movement of the shoulder was 60° for forward flexion and abduction, and 45° for backward flexion.DiscussionDespite the follow-up time was still short, the use of the constrained shoulder joint with the applications of patient-specific 3D printing showed very positive outcomes. Patient was able to start rehabilitative early without any problems. More follow-up time would be needed to evaluate the long-term effectiveness of this method.ConclusionTotal scapular replacement with constrained reverse shoulder joint using 3D printing technology is a suitable option for the patients with scapular tumor invading the muscles of the rotator cuff.
Predicting protein-protein interactions between banana and Fusarium oxysporum race 4 integrating sequence and domain homologous alignment and neural network verification
Authors: Fang Hui , Zhong Cheng , Tang Chunyan 
Published: November 2021

Abstract
Background: The pathogen of banana Fusarium oxysporum race 4 (Foc4) infects almost all banana species, and it is the most destructive. The molecular mechanism of the interactions between Fusarium oxysporum and banana still needs to be further investigated.Methods: We use both the homology-interolog and domain-domain method to predict the protein-protein interactions (PPIs) between banana and Foc4. The predicted protein interaction sequences are encoded by the conjoint triad and autocovariance method respectively to obtain continuous and discontinuous information of protein sequences. This information is used as the input data of the neural network model. The Long Short-Term Memory (LSTM) neural network five-fold cross-validation and independent test methods are used to verify the predicted protein interaction sequences. To further confirm the PPIs between banana and Foc4, the Go functional annotation and interaction network analysis are carried out.Results: The experimental results show that the PPIs for banana and foc4 predicted by our proposed method may interact with each other in terms of sequence structure and GO functional annotation, and Foc4 protein plays a more active role in the process of Foc4 infecting banana.Conclusions: This study obtained the PPIs between banana and Foc4 by using computing means for the first time, which will provide data support for molecular biology experiments.
Efficient Processing of Top-k Frequent Spatial Keyword Queries
Authors: Xu Tao , Xu Aopeng , Mango Joseph , Liu Pengfei , Ma Xiaqing , Zhang Lei 
Published: November 2021

Abstract
The rapid popularization of high-speed mobile communication technology and the continuous development of mobile network devices have given spatial textual big data (STBD) new dimensions due to their ability to record geographical objects from multiple sources and with complex attributes. Data mining from spatial textual datasets has become a meaningful study. As a popular topic for STBD, the top-k spatial keyword query has been developed in various forms to deal with different retrievals requirements. However, previous research focused mainly on indexing locational attributes and retrievals of few target attributes, and these correlations between large numbers of the textual attributes have not been fully studied and demonstrated. To further explore interrelated-knowledge in the textual attributes, this paper defines the top-k frequent spatial keyword query (tfSKQ) and proposes a novel hybrid index structure, named RCL-tree, based on the concept lattice theory. We also develop the tfSKQ algorithms to retrieve the most frequent and nearest spatial objects in STBD. One existing method and two baseline algorithms are implemented, and a series of experiments are carried out using real datasets to evaluate its performance. Results demonstrated the effectiveness and efficiency of the proposed RCL-tree in tfSKQ with the complex spatial multi keyword query conditions.
Inhibition of DNA Topoisomerases I and II and Cytotoxicity of Compounds from Polygonum aviculare L .
Authors: Yu Yue , Zheng Xue-dan , Piao Meng-hua , Wang Yi-ming , Li Gao , Jin Mei , Zheng Ming-shan 
Published: November 2021

Abstract
Six flavonoid glycosides ( 1 – 3 , 6 – 8 ), one lignan ( 4 ), and one galloyl glycoside ( 5 ) were isolated based on the phytochemical study for the MeOH extract of Polygonum aviculare L. herb. The eight isolated compounds' structures were determined by comparing their physicochemical and spectral data with published ones. Compounds 5 and 6 were first isolated from this plant, and all the compounds were evaluated for DNA topoisomerase inhibitory activities and cytotoxicities. Among the purified compounds, 5 showed stronger inhibitory activity against topoisomerase I with an IC 50 value of 12.0 μM, while the value of positive control camptothecin (CPT) was 17.0 μM. For compounds 1 , 3 , and 5 – 8 , the value ranged from 0.054 to 17.0 µM, suggesting more potent inhibitory activity against topoisomerase II, and that of etoposide (VP-16) was 28.0 µM. Particularly, compounds 6 and 8 (IC 50 = 0.054 and 0.077 µM, respectively) inhibited Topo II about 500 times stronger than VP-16, making them safer agents of DNA topoisomerase. Furthermore, all compounds demonstrated no cytotoxic activity against four cancer cell lines. This study is the first to report the inhibition of DNA topoisomerases of compounds from P. aviculare , suggesting that these compounds may be potential candidates for treating cancer.
A Simulation Framework for Evaluating Statistical Methods for Quality Control in Manufacturing
Authors: Fries Niklas , Rydén Patrik 
Published: November 2021

Abstract
Statistical methods are commonly used to monitor quality in manufacturing processes. We consider a set of problems where the probability that a unit is defect, i.e., the defect probability, is influenced by a large number of sub-processes, and where the overall aim is to monitor the defect probability and link abnormalities in quality to observed production variables. We developed a simulation framework for studying the performances of statistical methods used to solve the considered problem. Fourteen prediction procedures were obtained by combining six prediction methods (linear regression, logistic regression, LASSO, penalized logistic regression, support vector machines, gradient boosting decision trees) and two pre-processing procedures. These prediction procedures were evaluated on four types of simulated datasets with different relationships between the explanatory variables and the defect probabilities. Additionally, two established methods for variable selection were compared to a novel method called mixed moments selection (MMS). MMS was more robust than the other methods, performed well on all dataset types, and can easily be combined with any type of prediction method. Additionally, it was shown that it can be advantageous to complement the original explanatory variables with their squared values prior to analyzing the data. Overall, a procedure combining MMS, including additional quadratic terms and using PLR had the best performance. The proposed framework can be applied to evaluate any type of prediction procedure for the general problem we consider. This would increase the understanding of different procedures and facilitate the selection of procedures for a specific problem.
Association between Cognitive Impairment and Olfactory Deficits in Systemic Lupus Erythematosus Without Major Neuropsychiatric Syndromes
Authors: Xu Xue , Kong Wei , Geng Linyu , Chen Chen , Yang Hailong , Kong Wentao , Wen Baojie , Bian Wenjuan , Chen Siwen , Xu Renju , Jun Liang , Sun Lingyun 
Published: November 2021

Abstract
Objective Cognitive impairment is a common neuropsychiatric manifestation of systemic lupus erythematosus (SLE). However, it is not routinely assessed despite its high morbidity and mortality. The aim of the study was to investigate the utility of a brief neuropsychological battery, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), to evaluate cognitive deficits in patients with SLE and to examine the relationship between cognitive and olfactory function. Methods Fifty-five SLE patients and 50 age- and sex-matched healthy control subjects were administered the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), a cognitive screening battery that evaluated five index of cognition including immediate memory (IMME), visuospatial/constructional (Vis/Con), language (LANG), attention (ATT), delayed memory (DEME). Olfactory functions were evaluated using olfactory function assessment by computerized testing including the three stages of smell: threshold (THR), identification (ID) and memory (ME) of the different odors. The disease activity and cumulative damage were assessed by the SLE Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology(ACR) Damage Index (SDI). Results Patients with SLE exhibited significant lower total RBANS score, IMME, Vis/Con, ATT and DEME index scores than normal controls (P < 0.01 for all and P = 0.027 for attention). Performances on RBANS immediate memory, language, attention and total scores were correlated with education level of SLE patients. Reduced RBANS index and total scores were associated with several organ involvement and autoantibodies. SLE patients with higher SLEDAI-2K scores or with accumulated damage (SDI≥1) showed decreased RBANS scores than patients with lower SLEDAI-2K scores or without accumulated damage. All the olfactory scores (THR, ID and ME) in patients with SLE were significantly decreased than the control group (all P = 0.001). Patients had higher proportion of anosmia (8.57% vs 0%) and hyposmia (28.58% vs 5.72%) than controls (χ2 = 10.533, P = 0.015). Multivariable regression analysis revealed that olfactory threshold, identification and memory had a positive effect on RBANS index score. Olfactory memory and total score were significantly correlated with the RBANS delayed memory (r = 0.393, P = 0.021) and total scores (r = 0.429, P = 0.011).Conclusion The results of this study indicate that significantly correlated cognitive and olfactory functions are impaired in SLE patients. The RBANS is a potentially useful instrument for evaluating neuropsychological status in SLE. Physicians are encouraged to perform routine screening in patients with SLE to detect subtle cognitive dysfunction and strategize early treatment options.
Trauma and sinusitis induce orbital cellulitis in an 11-year-old boy
Authors: Liang Cong , Zheng Ru-Jiang , Li Su-Ping , Li Yi-Juan , Xu Ling-Ling 
Published: November 2021

Abstract
Background

We conducted a literature review and found that the most common causes of orbital cellulitis susceptibility in children are infections in adjacent areas (such as sinusitis, dental disease, upper respiratory tract infections, and facial skin infections), recent trauma/surgery, foreign bodies, and insect bites. This article aims to discuss the differential diagnosis and treatment of orbital cellulitis in children.
Case presentation:

Here we present a report of a case of orbital cellulitis with intra-frame abscess induced by trauma and sinusitis, and a review of the relevant literature. An 11-year-old boy with a history of orbital trauma one year earlier had had fever, pain in the right eye, periorbital swelling, restricted extraocular movement, protruding eyes, and decreased vision for six days before admission. The initial treatment with intravenous Rocephin and linezolid was unsuccessful. MRI showed sinusitis and orbital abscess. Endoscopic sinus surgery was then performed to clean up the purulent secretions in the orbit, which relieved his orbital symptoms.
Conclusions

Here, we report a case of sinusitis and trauma-induced orbital cellulitis in an 11-year-old boy. The use of intravenous antibiotics and further treatment with orbital incision and decompression led to clinical improvement. Children with orbital complications of acute sinusitis have complex clinical manifestations and rapid disease progression. Our literature review findings suggest that broad-spectrum antibiotics are the main empirical treatment, and abscesses are not an absolute indication for immediate surgery. Therefore, dynamic evaluation, multidisciplinary consultations, and surgical treatment (if necessary) should be performed in cases of orbital cellulitis.
Parental Oral Hygiene Knowledge: Investigating the Source for Successful Oral Hygiene Behavior in Children
Authors: Moore Ed.D. Wallace 
Published: November 2021

Abstract
Background

The deleterious effects of dental caries in children can often be arrested if parents are knowledgeable regarding dental treatment. The purpose of this study was to examine the relationship between a parent’s level of oral hygiene knowledge and the oral hygiene behaviors of their children ages 7 to 17 in the greater United States.
Methods

The researcher utilized a quantitative descriptive study based on a non-experimental cross-sectional survey design. 103 participants voluntarily responded. To be eligible, participants had to live in the greater United States and have a child between the ages of 7 to 17.
Results

Data analysis was completed using inferential statistics while utilizing the chi-square test of independence as the analytical method. The Chi-Square test was used to determine whether a relationship between the parent’s hygiene knowledge and the child’s oral hygiene behaviors existed. Results did reveal an association between the variables, a parent’s hygiene knowledge and their child’s oral health hygiene behaviors upon completion of the chi-square test analysis.
Conclusions

The oral hygiene knowledge of some parents needs to be increased to ensure positive outcomes with their child’s oral hygiene behaviors—information about pit and fissure sealants to aid in the prevention of dental caries for their children would be highly advantageous. Additionally, further studies are warranted to address possible limitations of the child and parental socioeconomic issues.