bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double-bundle Anatomic Anterior Cruciate Ligament Reconstruction Using Hamstring-bone Graft: a Long-term Follow Up
Authors: Gan Jingyue , Li Jie , Martin Vidmi Taolam , Liu Ke , Yu Bo 
Published: February 2021

Abstract
Purpose We modified the hamstring tendon graft into the hamstring-bone composite graft in double-bundle anterior cruciate ligament reconstruction for anterior cruciate ligament (ACL) injuries. Here, we evaluated the technique's effectiveness by investigating the clinical results in restoring the stability and function of the knee joint. Methods We reviewed 42 patients who underwent anterior cruciate ligament reconstruction (ACLR) with the hamstring-bone graft for ACL injuries from January 2013 to April 2015, with an average follow-up of 66.6 months. The objective evaluations (KT-1000, Lachman test and pivot-shift test) and the subjective evaluations (International Knee Documentation Committee (IKDC) scores, Lysholm scores, and Tegner scores) were performed preoperatively and postoperatively. Results Forty-one of 42 patients were negative in the Lachman test and forty of 42 patients were negative in the pivot-shift test after the operation at the final follow-up time. The IKDC, Lysholm, and Tegner scores improved significantly from 56.24±9.28 to 85.33±3.37, from 62.00±11.09 to 90.43±3.71，and from 2.3±0.87 to 6.5±0.67 at the final follow-up. Conclusion Double-bundle anatomic ACLR with a hamstring-bone composite graft can restore the anteroposterior and rotational stability for ACL injuries. The modified technique can provide excellent clinical outcomes with a long-term follow-up.
Comprehensive Analysis of a Ferroptosis-related Gene Signature for Overall Survival and Immunotherapy Response in Patients With Bladder Urothelial Carcinoma
Authors: Weng Hong , Deng Tong , Yuan Shuai , Huang Qiao , Zeng Xian-Tao , Wang Xing-Huan 
Published: February 2021

Abstract
Background: Bladder urothelial carcinoma (BLCA) is the most common malignant tumor of the urinary system. Ferroptosis is a new type of programmed cell death that is iron-dependent and different from apoptosis, cell necrosis, and autophagy. Studies have indicated that many genes are involved in regulating ferroptosis or markers of ferroptosis. However, the value of genes related to ferroptosis in BLCA remains unclear.Methods: We comprehensively evaluated the differences in ferroptosis genes in patients with BLCA and control samples based on public databases, including mRNA expression, mutations, and copy number variations. The ferroptosis gene expression profile was used for consistent clustering to obtain ferr.clusterA and ferrclusterB. An analysis of differences between groups was performed to obtain ferroptosis-related gene, and then consistent clustering was performed to obtain ferr.gene.cluster A and ferr.gene.clusterB. Subsequently, the random forest algorithm was used to reduce dimensionality, Cox analysis was used to screen characteristic genes, principal component analysis was performed, and the ferroptosis score was constructed to quantify the ferroptosis expression of a single sample.Results: According to the ferroptosis score, the samples could be divided into two groups with significant differences in prognosis, which proves that the ferroptosis expression pattern in a single tumor can predict the prognostic response of patients.Conclusion: In summary, ferroptosis-related genes are significantly related to the progression of BLCA.
Influence of Febrile Urinary Tract Infection on Ultrasonic Measurements of Nonreflux Upper Urinary Tract Dilation in Infants
Authors: Li Peiqiang , Liu Fuyun , Huang Yan 
Published: February 2021

Abstract
Background To investigate the changes in ultrasonic measurements of nonreflux upper urinary tract dilation in infants with febrile urinary tract infection (UTI).Methods There were 28 cases of nonreflux upper urinary tract dilatation with febrile UTI: 14 cases of ureteropelvic junction obstruction (UPJO) (14 kidneys) and 14 cases of ureterovesical junction obstruction (UVJO) (16 kidneys). Changes in anteroposterior renal pelvic diameter (APD) and ureteral dilatation during infection and after infection were compared in UPJO and UVJO patients, respectively.Results In the UPJO with febrile UTI group, the APD was 24.1±10.0 mm at the time of UTI and 16.6±7.0 mm 1 week after infection recovery (P<0.001). In the UVJO with febrile UTI group, the APD was 19.3±8.5 mm at the time of UTI and 15.2±7.7 mm 1 week after infection recovery (P<0.001). In the UVJO with febrile UTI group, the ureteric diameter was 11.0±3.2 mm during UTI and 6.8±2.6 mm 1 week after infection recovery (P<0.001).Conclusions In UPJO patients, the APD decreased after febrile UTI treatment compared with that during infection. In UVJO patients, the APD and ureteric diameter decreased after febrile UTI treatment compared with that during infection.
Serum IGFBP-2 in Systemic Sclerosis as a Prognostic Factor of Lung Dysfunction
Authors: Guiot Julien , Njock Makon-Sébastien , André Béatrice , Gester Fanny , Henket Monique , Seny Dominique de , Moermans Catherine , Malaise Michel G , Louis Renaud 
Published: February 2021

Abstract
Background: Systemic sclerosis (SSc) is a rare connective tissue disease associated with rapid evolving interstitial lung disease (ILD), driving its mortality. Specific biomarkers associated with the progression of this lung disease are highly needed. We aimed to identify specific biomarkers of SSc-ILD to predict the evolution of the disease.Methods: We compared prospectively serum levels of several biomarkers associated with lung fibrosis in SSc patients (n=102), among which SSc-no ILD (n=63) and SSc-ILD (n=39), compared to healthy subjects (HS) (n=39). We also performed a longitudinal study in a subgroup of 28 patients analyzing biomarkers variations and pulmonary function tests over a period of 2 years.Results: Serum level of IGFBP-2 was significantly increased in SSc patients compared to HS, and negatively correlated with pulmonary function (assessed by carbon monoxide transfer coefficient (KCO)) (r=-0.29, p<0.01). Two-year longitudinal analysis in a subgroup of 28 SSc patients determined that IGFBP-2 variation was positively correlated with KCO at 2-year follow-up (r=0.6, p<0.001). SSc patients with a lower variation of IGFBP-2 (less than 22%) presented significant degradation of pulmonary function at 2-year follow-up (p<0.01). ROC curve analysis enabled us to identify that baseline IGFBP-2 > 105 ng/ml was associated with a poor outcome (KCO <70% predicted) at 2-year follow-up (AUC=0.75, p<0.05).Conclusions: We showed for the first time that serum levels of IGFBP-2 might be a prognostic factor of the development of SSc-ILD. Indeed, initial level of IGFBP-2 above 105 ng/ml was associated with a poor patient’s outcome (KCO <70% predicted) two years later.
Case Series: Refractory Cases of Hyper-serum IgE Achieve Transformative Decrease by TCM Therapy
Authors: Neshiwat Johnathan , Mcknight Tory , Uzun Serife , Ehrlich Paul , Chung Danna , Li Xiumin 
Published: February 2021

Abstract
Background:Chronic conditions from IgE-mediated hypersensitivity reactions affect over 150 million Americans, but affordable and effective treatment options remain largely unavailable to the pediatric population. Traditional Chinese medicine has been shown to reduce IgE levels in refractory cases of hyper-serum IgE and have transformative effects in pediatric patients with chronic allergic inflammation.Presentation:Here we present ten patients with chronic atopic conditions and refractory hyper-serum IgE who were treated with TCM therapy. The patients had at least two atopic conditions as well as multiple allergic sensitivities to foods and environmental allergens: all of the patients presented with food allergies (FA) and atopic dermatitis (AD), 60% of patients presented with an environmental allergy (EA), 40% of patients presented with asthma (AS), 10% had celiac disease (Celiac), and 10% had eosinophilic esophagitis (EoE). All of the affected patients had IgE levels greater than 5,000kIU/L (normal =300kIU/L) prior to treatment. None of the patients had an IgE of greater than 5,000kIUL after treatment. We treated 10 children with IgE-mediated hypersensitivity reactions using topical and oral TCM and found an average reduction of 3,723kIU/L IgE per patient (p=0.01) or 79%. Conclusion:We present a ten-patient case series on the effective lowering of hyper-serum IgE using Traditional Chinese Medicine in otherwise refractory pediatric cases of chronic atopic inflammation. TCM is an affordable and safe alternative for chronic atopic conditions compounded with hyper-serum IgE. Future research via random controlled trials should be used to test the efficacy of TCM.
Time Evolution of Tectonic Earthquake in Ambon, Indonesia
Authors: Astra I Made Kris Adi , Rietbrock Andreas , Toularoud Nasim Karam Zadeh 
Published: February 2021

Abstract
The advancement of earthquake seismology brings a new insight into earthquake detection. Advanced signal processing by implementing sliding-window mathematical techniques of cross-correlation into data stream are able to recognize low amplitude earthquake signals even under the presence of noise. Clear detection of the onset of low amplitude seismic waves is crucial, however they often hidden by larger amplitudes of coda waves after the generation of mainshock event. By performing template matching algorithm we found a detail temporal variation of seismicity related to Mw 6.6 Ambon earthquake. In comparison, the detection level is up to eight times from conventional method. The method also reveals a seismic migration before the main event coincide with the direction of local tectonic movement derived from previous GPS analysis. Since the method able to detect the earthquake within their family, it gives a reasonably significant improvement to virtual stress-meter analysis. Highly accumulated stress preceding the main event depicted by b-value drop are clearly mapped in a high confidence level.
Spinal Muscular Atrophy: The High Costs of Innovative Therapies for Rare Diseases
Authors: Brennenstuhl Heiko , Green Kim , Störzinger Dominic , Hoppe-Tichy Torsten , Burgard Peter , Klein Ulrike , Kölker Stefan , Neitemeier Sandra , Schoch Goentje-Gesine , Steimle Tim , Baas Jens , Hoffmann Georg F. , Autenrieth Ingo B. , Ziegler Andreas 
Published: February 2021

Abstract
Background: Despite numbers of prescriptions filled remaining constant, expenditures for drugs are rising. Among others, this is caused by high prices for orphan drugs and advanced therapy medicinal products (ATMPs). Despite attempts by policymakers to intervene, the increasing use of these therapies poses numerous challenges on the health care system.Results: Using data from the University Hospital Heidelberg, we found that the division of pediatric neurology is experiencing a strong increase in drug costs, caused by two pharmaceuticals for the treatment of spinal muscular atrophy (SMA), Nusinersen and Onasemnogene Abeparvovec. To put this finding in a broader context, we conducted a survey of 41 German SMA treatment centers revealing a general lack of human and infrastructure resources for therapy and follow-up care, which demonstrates insufficient reimbursement of treatment. To improve structural conditions, we propose that disease-independent registries for medication surveillance that comply with the rules of the European Union are needed as well as the development of a fair funding model.Conclusion: Innovative forms of therapy require a critical discussion and concise regulation of treatment application and follow-up reimbursement as well as international industry-independent registry work. Based on the previously described model of “evidence-based dynamic pricing” by the Techniker Krankenkasse, we propose a revised model which offers an internationally scalable solution to meet these challenges.
Analysis of trace elements released from glass ionomer restorative materials by inductively coupled plasma-mass spectrometry
Authors: Ozmen Bilal , Aksoy Emre 
Published: February 2021

Abstract
Background

The aim of this study was to determine the amount of trace elements released from a traditional glass ionomer, a bulk-fill glass ionomer, a resin-modified glass ionomer, a glass carbomer fill and a compomer material stored in ultra-distilled water.
Methods

Ten cylindrical (10×2mm) specimens were prepared from each material. Each sample was stored in 50mL ultra-distilled water at 37°C for fourteen days, and rinsed twice daily. The amount of elements in the solutions was determined using inductively coupled plasma-mass spectrometry.
Results

Aluminum, boron, nickel, copper, zinc, barium and lead were detected in all solutions. The traditional glass ionomer and resin-modified glass ionomer released arsenic, the bulk-fill glass ionomer and compomer released selenium, and the resin-modified glass ionomer and compomer released antimony. Only the resin-modified glass ionomer released iron.
Conclusion

All materials tested released some trace elements, but the rates were quite low. Therefore, these glass ionomer materials can be used safely in dentistry.
The relation of vertebral artery occlusion and intravertebral cleft: a prospective magnetic resonance angiography study
Authors: Zhang Tianyu , Xue Feng , Kang Yu , Wang Yanhua , Zhang Peixun , Zhang Dianying , Jiang Baoguo 
Published: February 2021

Abstract
PurposeTo detect the relationship between the vertebral artery occlusion and the intravertebral cleft (IVC).MethodsA prospective evaluation of the vertebral segmental artery condition from the T10 to L4 with the magnetic resonance angiography (MRA) was performed in 44 osteoporosis vertebral compression fracture (OVCF) patients. The artery condition was divided into the patency, narrow, occlusion. The lesion segmental occlusion rate (LSOR) and the total occlusion rate (TOR) was calculated. The relation of the vertebral artery occlusion and the IVC formation was assessed with the univariate analysis. ResultsLOSR was 15.34% and TOR was 15.2%. The segmental arteries of the unfractured vertebrae had higher occlusion rate in thoracolumbar levels than non-thoracolumbar levels. Neither lesion levels arteries occlusion nor the total segmental arteries occlusion was associated with the IVC.ConclusionsVertebral compression fracture did not lead to the segmental artery occlusion. The segmental artery occlusion more likely happened in the thoracolumbar levels. The segmental artery occlusion did not lead to the IVC.
Decomposition and Temperature Sensitivity of Fine Root and Leaf Litter of 43 Mediterranean Species
Authors: Bonanomi Giuliano , Idbella Mohamed , Zotti Maurizio , Santorufo Lucia , Motti Riccardo , Maisto Giulia , Marco Anna De 
Published: February 2021

Abstract
Aims:

Data on the decomposition of fine roots are scarce for the Mediterranean basin. This work aims to compare chemical traits, decomposition rate, and temperature sensitivity (Q10) for root and leaf litter of 43 Mediterranean species.
Methods:

We carried out a two-years litterbag decomposition experiment using 43 fine roots litter and leaf litter types incubated in laboratory conditions at three different temperatures, i.e. 4°C, 14°C, and 24°C. Litter was characterized for carbon (C), nitrogen (N), lignin and cellulose concentration, C/N, and lignin/N ratios.
Results:

Fine root litter had lower N content but higher lignin concentration, lignin/N, and C/N ratios compared to leaf litter. The decay rate of fine root litter was slower than leaf litter. For both tissues, the decay rate was negatively associated with lignin concentration, lignin/N, and C/N ratios but positively with N concentration. Q10 was higher for fine root than leaf litter, with a positive correlation with lignin while negative with N concentration.
Conclusions:

Our findings demonstrate a higher Q10 accompanied by a slower decomposition rate of fine root litter compared to leaf litter in Mediterranean ecosystems. These results must be considered in modeling organic C at the ecosystem scale.
Emergence of meropenem/vaborbactam resistance in KPC-producing Klebsiella pneumoniae causing bloodstream infections in northern Italy, 2018
Authors: Gaibani Paolo , Lombardo Donatella , Bussini Linda , Bovo Federica , Giannella Maddalena , Bartoletti Michele , Viale Pierluigi , Re Maria Carla Carla , Ambretti Simone 
Published: February 2021

Abstract
We aimed to investigate the incidence of meropenem/vaborbactam-resistance among KPC-producing Klebsiella pneumoniae (KPC-Kp) bloodstream infection in a large Italian hospital. Meropenem/vaborbactam-resistance was found in 8% (n = 5) KPC-Kp, while 5% (n = 3) strains exhibited cross-resistance to ceftazidime/avibactam. Genomic analysis revealed that meropenem/vaborbactam-resistance was associated to non-functional OmpK35 and OmpK36 porins and no specific mutation was associated to cross-resistance. No specific antimicrobial treatment was related to favorable clinical outcome, while cross-resistance was not associated to higher clinical and/or microbiological failures. Our study indicated that resistance to meropenem/vaborbactam was due to porins deficiency and is associated to reduced susceptibility both to ceftazidime/avibactam and carbapenems.
Empiric use of Anticoagulation in Hospitalized Patients with COVID-19: A Propensity Score-Matched Study of Risks and Benefits
Authors: Yu Bo , Gutierrez Victor Perez , Carlos Alex , Hoge Gregory , Pillai Anjana , Kelly J. Daniel , Menon Vidya 
Published: February 2021

Abstract
Background: Hospitalized patients with COVID-19 demonstrate a higher risk of developing thromboembolism. Anticoagulation (AC) has been proposed for high-risk patients, even without confirmed thromboembolism. However, benefits and risks of AC are not well assessed due to insufficient clinical data. We performed a retrospective analysis of outcomes from AC in a large population of COVID-19 patients. Methods: We retrospectively reviewed 1189 patients hospitalized for COVID-19 between March 15 and May 15, 2020, with primary outcomes of mortality, invasive mechanical ventilation, and major bleeding. Patients who received therapeutic AC for known indications were excluded. Propensity score matching of baseline characteristics and admission parameters was performed to minimize bias between cohorts. Results: The analysis cohort included 973 patients. Forty-four patients who received therapeutic AC for confirmed thromboembolic events and atrial fibrillation were excluded. After propensity score matching, 133 patients received empiric therapeutic AC while 215 received low dose prophylactic AC. Overall, there was no difference in the rate of invasive mechanical ventilation (73.7% versus 65.6%, p = 0.133) or mortality (60.2% versus 60.9%, p = 0.885). However, among patients requiring invasive mechanical ventilation, empiric therapeutic AC was an independent predictor of lower mortality (hazard ratio [HR] 0.476, 95% confidence interval [CI] 0.345-0.657, p < 0.001) with longer median survival (14 days vs 8 days, p < 0.001), but these associations were not observed in the overall cohort (p = 0.063). Additionally, no significant difference in mortality was found between patients receiving empiric therapeutic AC versus prophylactic AC in various subgroups with different D-dimer level cutoffs. Patients who received therapeutic AC showed a higher incidence of major bleeding (13.8% vs 3.9%, p < 0.001). Furthermore, patients with a HAS-BLED score of ≥2 had a higher risk of mortality (HR 1.482, 95% CI 1.110-1.980, p = 0.008), while those with a score of ≥3 had a higher risk of major bleeding (Odds ratio: 1.883, CI: 1.114-3.729, p = 0.016). Conclusion: Empiric use of therapeutic AC conferred survival benefit to patients requiring invasive mechanical ventilation, but did not show benefit in non-critically ill patients hospitalized for COVID-19. Careful bleeding risk estimation should be pursued before considering escalation of AC intensity.
Gene-to-trait knowledge graphs show association of plant photoreceptors with physiological and developmental processes that can confer agronomic benefits
Authors: Mawkhiew Hamebantei , Sahoo Lingaraj , Kharshiing Eros 
Published: February 2021

Abstract
Global population growth, climate change, altered precipitation rates and cropping patterns are increasingly challenging plant scientists to improve crop productivity for food and non-food applications. Hence, there is a pressing need for identifying candidate gene that can be targeted for breeding future crops having enhanced agronomic benefits. Network mapping utilises available data and creates knowledge graphs that aid in visualising association(s) between the individual data items. Here, we have generated gene-to-trait knowledge graphs of known plant photoreceptors using the KnetMiner gene discovery platform which generates biological networks from literature/data sets available in public databases. The resulting knowledge graphs indicate a close association of photoreceptors with various physiological and developmental processes such as shoot architecture, yield, disease resistance and water use efficiency among others, that can confer agronomically important benefits. Such information can be of assistance to plant biologists in the selection of potential gene targets for improving agronomically beneficial traits in plants. This report highlights the potential of machine learning and knowledge graphs as aids in more efficient knowledge discovery and novel decision-making processes which can also be employed for crop breeding or crop engineering.
Fraud Detection: A Study of AdaBoost Classifier and K-Means Clustering
Authors: Mishra Anwesha 
Published: February 2021

Abstract
Fraud is a problem which can affect the economy greatly. Billions of dollars are lost because of fraud cases. These problems can occur through credit cards, insurance and bank accounts. Currently there have been many studies for preventing fraud. Machine learning techniques have helped in analysing fraud detection. These include many supervised and unsupervised models. Neural networks can be used for fraud detection. The dataset for the present work was collected from a research collaboration between Worldline and the Machine Learning Group of Université Libre de Bruxelles on the topic of big data mining and fraud detection. It consists of the time and amount of various transactions of European card holders during the month of September in 2013. This paper gives an analysis of the past and the present models used for fraud detection and presents a study of using K-Means Clustering and AdaBoost Classifier by comparing their accuracies.