bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Evaluation of the Feasibility of Implementing a Novel Tobacco Dependence Treatment Program for High-risk Individuals Into Clinical Practice Within a Community Mental Health Center
Authors: Hogan Tory , Quisenberry Amanda , Breitborde Nicholas , Moe Aubrey , Ferketich Amy 
Published: May 2021

Abstract
Background: Individuals with serious mental illnesses experience deaths related to smoking at a higher prevalence than individuals without a serious mental illness. Traditional smoking cessation programs are often not effective among individuals with chronic mental disorders. Little is known about how to implement a tobacco cessation treatment programs for this at-risk population within a community health centers. The current study used qualitative methods to examine the factors that may enhance or impede the delivery of a novel tobacco cessation treatment for smokers with a psychotic-spectrum disorder diagnosis in an integrated care community health center. Methods: Using purposeful sampling, we conducted 22 semi-structured interviews with primary care providers, mental health providers, addiction counselors, case managers, intake specialists, schedulers, pharmacists, and administrative staff at employed at the organization. Interviews were transcribed and themes were identified through a rich coding process. Results: We identified environmental factors, organizational factors, provider factors and patient factors which describe the potential factors which may enhance or impede the implementation of a smoking cessation program at the integrated care community health center. Most notably we identified that community mental health centers looking to implement a smoking cessation program for individuals with chronic mental health disorders should ensure that the incentives for providers to participate align with the program’s objectives. Lastly, organizations should invest in educating providers to address stigma related to smoking cessation and nicotine use. Conclusions: The findings of our study provide valuable insight for administrators to consider when implementing a smoking cessation program in an integrated care community health center. Our findings provide public health practitioners with potential considerations that should be discussed when designing and implementing a smoking cessation program for individuals with chronic mental disorders.
An observational study on Assessment of disease activity in Rheumatoid Arthritis patients using Patient based Disease Activity Score 2 (PDAS 2)
Authors: Singh Harpreet , Giri Somdatta , Kumar Hemant , Yonzone Pratibha , Khatkar Mahima 
Published: May 2021

Abstract
Objective
To assess the utility of Patient Based Disease Activity Score 2 (PDAS 2) in assessing the disease activity in Rheumatoid arthritis (RA).
Methods
A prospective cohort study was conducted on 80 patients of RA. The demographic and clinical characteristics of the patients were recorded. They were assessed for disease activity using “Disease Activity Score 28” (DAS 28), “Clinical Disease Activity Index” (CDAI) and PDAS 2 score at baseline (M0), at 2 months (M2) and at 4 months(M4) while they were on treatment. Data was analyzed for correlation of PDAS-2 with other scores and internal reliability. P < 0.05 was considered for statistical significance.
Results
The mean age was 40.13\(\pm\) 11.74 years with 70 females and 10 males. There was significant reduction in DAS28, CDAI and PDAS 2 score over 4 month follow up (all scores’ p values < 0.001). Internal reliability (as assessed by Cronbach’s Alpha) of PDAS 2 was 0.578. PDAS 2 showed significant correlation with DAS28 at M0, M2 and M4 (r = 0.792, 0.757 and 0.669 respectively, p value < 0.001) and CDAI (r = 0.861, 0.832 and 0.695 respectively, p value < 0.001). Overall there was a significant agreement between DAS 28 and PDAS 2 (K = 0.788,p < 0.001) and between CDAI and PDAS 2 (K = 0.766,p < 0.001).
Conclusion
PDAS-2 score can be routinely used in the clinical practice owing to its correlation with DAS-28/CDAI and because of the advantage that it assessed the patients’ daily living activities.
A new quantitative evaluation system for distal radioulnar joint instability using a three-dimensional electromagnetic sensor
Authors: Mukohara Shintaro , Mifune Yutaka , Inui Atsuyuki , Nishimoto Hanako , Yamaura Kohei , Yoshikawa Tomoya , Shinohara Issei , Hoshino Yuichi , Nagamune Kouki , Kuroda Ryosuke 
Published: May 2021

Abstract
Background The accurate assessment of distal radioulnar joint (DRUJ) instability is still challenging as there is no established objective evaluation method. This study aimed to develop a noninvasive measurement method using a three-dimensional electromagnetic sensor system (EMS) to quantitatively assess and characterize the normal DRUJ movement in healthy volunteers. Methods The DRUJ movement was mimicked using both a block model and saw bone. Movement of the models was measured by EMS, and the accuracy and reproducibility of the measurements were assessed. The movement was evaluated in 14 healthy volunteers (7 men and 7 women) by three hand surgeons. Measurement was done in a sitting position with the elbow flexed and the forearm pronated. One sensor each was attached to the distal radial shaft and the ulnar head. The examiners fixed the distal radius and moved the ulnar head from the dorsal to the volar side, measuring the dorsovolar ulnar head translation. The intraclass and interrater correlation coefficients (ICCs) were calculated using the average values of the measurements. The differences between the dominant and non-dominant sides and between men and women were also assessed. Results The accuracy and reproducibility assessment results of the EMS showed high accuracy and reproducibility. The ICC (1,5) for the intra-rater reliability was 0.856, and the ICC (2,5) for inter-rater reliability was 0.868. The mean ulnar head translation and difference between dominant and non-dominant sides were 6.00 ± 1.16 mm (Mean ± SD) and -0.12 ± 0.40 mm, respectively. There were no significant differences between any of the parameters.Conclusions A new measurement method using EMS could evaluate DRUJ movement with high accuracy, reproducibility, and intra- and inter-rater reliability. In healthy volunteers, the dorsovolar ulnar head translation was 6.00 mm. The difference between the dominant and non-dominant sides was < 1.0 mm with no significant difference. EMS provided an objective, non-invasive, real-time assessment of dynamic changes in the DRUJ. These findings could be useful in the treatment of patients with DRUJ instability.
Factors Associated with Knowledge, Attitude, and Practices of Physicians related to Autism spectrum disorder in Romania
Authors: Rahbar Mohammad H , Dobrescu Iuliana , Gillani Shezeen , Hessabi Manouchehr , Kim Sori , Stancu Mihaela , Rad Florina 
Published: May 2021

Abstract
Background
An inadequate level of general knowledge of physicians regarding mental health, including Autism Spectrum Disorder (ASD) not only could have adverse effects on affected individuals’ health and quality of life, but also could further delay its diagnosis and initiation of timely interventions. The purpose of this survey was to assess the level of knowledge, attitudes, and practices (KAP) of physicians regarding ASD in Romania and identify their associated factors.
Methods
For conducting this cross-sectional survey, investigators in the US collaborated with faculty at “Carol Davila” University of Medicine and Pharmacy (UMF) and developed a questionnaire by modifying similar questionnaires used in Pakistan and Turkey, to assess KAP of physicians and specialists regarding ASD in Romania. The Questionnaire was administered to a convenient sample of 383 practicing physicians or specialists. Exploratory Factor Analysis on 12 variables revealed five composite sub-scores: stigma, potential causes, children’s behavior, misconceptions, and educational needs associated with ASD knowledge. We determined the variables associated additively or interactively with KAP regarding ASD by applying General Linear Models to the five sub-scores as dependent variables.
Results
Approximately 75% of the responding physicians were female and more than 80% were over the age of 30 years. The majority (73%-94%) of physicians in Romania have correctly responded to some basic questions regarding knowledge about ASD. We also found that younger physicians (age < 35 years) were more knowledgeable about potential causes of ASD than older physicians, age ≥ 35 years, (adjusted mean sub-scores: 2.70 vs. 2.13, P = 0.04, adjusted for the “type of medical school attended” and “city where the clinic is located”), while older physicians knew more about the behavior of children with ASD (P = 0.02). We found a significant interaction between source of ASD knowledge and (city where the clinic is located) in relation to knowledge of the physicians’ regarding stigma related to ASD. There were no significant interactions in relation to the physician’s knowledge of behaviors of children with ASD.
Conclusion
Though Romanian physicians are knowledgeable about ASD, greater attention is needed on symptoms, causes, and awareness of stigma and misconceptions surrounding ASD.
Status of pulmonary fungal infections among individuals with clinical signs of pulmonary tuberculosis at a University Teaching Hospital in Southwestern Uganda.
Authors: Njovu Israel Kiiza , Musinguzi Benson , Mwesigye James , Kassaza Kennedy , Turigurwa Joseph , Nuwagira Edwin , Bazira Joel , Kabanda Taseera , Mpeirwe Moses , Ampaire Lucas , Mutekanga Andrew , Kiguli James , Achan Beatrice , Itabangi Herbert 
Published: May 2021

Abstract
Background: Pulmonary mycoses are very important diseases of the respiratory tract and are responsible for significant morbidity and mortality rates worldwide. However less attention has been paid to them. In this study we determined the prevalence of pulmonary mycoses and their aetiological agents among individuals with clinical signs of pulmonary tuberculosis at Mbarara Regional Referral Hospital (MRRH). Method: This was a Laboratory based cross sectional survey in which 113 participants were recruited. Sputum samples were corrected from each study participant. To each sample the following tests were done; Sabouraud Dextrose Agar (SDA) Culture, GeneXpert and Potassium hydroxide (KOH). Fungal growth of filamentous fungi and yeasts were further examined with LPCB and Germ tube respectively. Generated data was analysed using R studio. Results: Out of 113 participants, 80 (70.8%) had pulmonary mycoses whilst those with pulmonary tuberculosis were 5 (4.4%). C. albicans 22.58% and Aspergillus species 17.20%) were the most aetiological agents for pulmonary mycoses identified among others. Of those who were TB GeneXpert positive, 2 (1.77%) of them were co-infected with pulmonary mycoses. We established a prevalence of 57 (71.3%) for PFI, 3 (60.0%) for MTB in HIV sero positive patients and 18 (22.5%) for PFI, 0 (0.00%) for MTB in HIV sero negative patients. On the other hand, 2 (100%) sero positive patients were co-infected with both PFI and MTB.Conclusion: Our findings highlight the medical importance of pulmonary fungal infections among patients suspected for TB. Importantly, the aetiological diversity established here is rich enough to suggest precise examination using different methods. Established scope of aetiological agents is predominated by opportunistic fungi which when superimposed on to certain underlying conditions such as TB, their effects can be fatal. Therefore this possibility presents a need to employ appropriate strategies for prevention, diagnosis, and management in TB suspects.
Using Biometric Sensor Data to Monitor Cancer Patients During Radiotherapy: Protocol for the OncoWatch Feasibility Study
Authors: Holländer-Mieritz Cecilie , Vogelius Ivan R , Kristensen Claus A , Green Allan , Rindum Judith L , Pappot Helle 
Published: May 2021

Background
Patients with head and neck cancer (HNC) experience severe side effects during radiotherapy (RT). Ongoing technological advances in wearable biometric sensors allow for the collection of objective data (eg, physical activity and heart rate), which might, in the future, help detect and counter side effects before they become severe. A smartwatch such as the Apple Watch allows for objective data monitoring outside the hospital with minimal effort from the patient. To determine whether such tools can be implemented in the oncological setting, feasibility studies are needed.

Objective
This protocol describes the design of the OncoWatch 1.0 feasibility study that assesses the adherence of patients with HNC to an Apple Watch during RT.

Methods
A prospective, single-cohort trial will be conducted at the Department of Oncology, Rigshospitalet (Copenhagen, Denmark). Patients aged ≥18 years intended for primary or postoperative curatively intended RT for HNC will be recruited. Consenting patients will be asked to wear an Apple Watch on the wrist during and until 2 weeks after RT. The study will include 10 patients. Data on adherence, data acquisition, and biometric data will be collected. Demographic data, objective toxicity scores, and hospitalizations will be documented.

Results
The primary outcome is to determine if it is feasible for the patients to wear a smartwatch continuously (minimum 12 hours/day) during RT. Furthermore, we will explore how the heart rate and physical activity change over the treatment course.

Conclusions
The study will assess the feasibility of using the Apple Watch for home monitoring of patients with HNC. Our findings may provide novel insights into the patient’s activity levels and variations in heart rate during the treatment course. The knowledge obtained from this study will be essential for further investigating how biometric data can be used as part of symptom monitoring for patients with HNC.

Trial Registration
ClinicalTrials.gov NCT04613232; https://clinicaltrials.gov/ct2/show/NCT04613232

International Registered Report Identifier (IRRID)
PRR1-10.2196/26096
FORMULATION AND EVALUATION OF AMPHOTERICIN B AND MILTEFOSINE COMBINATION NANOVESICLES
Authors: BEZABEH MULUGETA F. , WERBOVETZ KARL A. , MURTHY K. V. RAMANA 
Published: May 2021

Objective: The aim of the present investigation is to formulate and evaluate amphotericin B-miltefosine combination nanovesicles for application in the treatment of visceral leishmaniasis.
Methods: Amphotericin B-miltefosine combination (AmB-MTF) nanovesicles were prepared by ethanol injection method. Formulations of nanovesicles were evaluated at varying conditions of lipids composition, drug-lipid proportion, ethanol-water composition and stirring rate, on drug entrapment efficiency and particle size.
Results: The study showed that entrapment efficiency was significantly affected (p<0.01) by the effects of lipids composition, drug-lipid proportion, ethanol-water composition, and stirring rate. Particle size of nanovesicles was significantly affected (p<0.05) by drug-lipid proportion and stirring rate. An optimized formulation of amphotericin B-miltefosine nanovesicles was prepared at optimal factors composition of: phosphatidylcholine-cholesterol-stearic acid 20:4:1, drug-lipid 1:8, AmB-MTF 1:1; ethanol-water 1:4 ratios, and stirring rate 1000 rpm. The AmB-MTF 1:1 nanovesicles formulation showed particle size of 145.6 nm, poly dispersity index 0.19, zeta potential-27.3 mV and drug entrapment efficiency 87%.
Conclusion: Evaluation of AmB-MTF 1:1 nanovesicles showed development of a successful formulation with very good compatibility, extended drug release, convenient vesicle size and high drug entrapment efficiency. To conclude, AmB-MTF 1:1 nanovesicles formulation could be a safe and reliable therapeutic option over the conventional combination therapy provided further antileishmanial investigations are investigated in vitro and in vivo.
Periode Masa Jabatan Hakim Konstitusi dan Implikasinya terhadap Kemandirian Kekuasaan Kehakiman (Term of Office for Constitutional Justices and Its Implications against Judicial Independence)
Authors: Hantoro Novianto Murti 
Published: May 2021

Constitutional justices have a five-year term and can be re-elected for only one subsequent term. There has been an effort to correct this provision through a request for judicial review of the Constitutional Court Law. Still, there is no decision by the Constitutional Court which states that the term of office of constitutional justice is against the 1945 Constitution of the Republic of Indonesia. This paper analyzes the need to reform the provisions regarding the term of office of constitutional justices associated with the principle of judicial independence. An analysis of the term of office of constitutional justices was also carried out by comparing international principles and practices in other countries. The term of office of 5 years and can be re-elected has its weaknesses, because it opens up opportunities for political influence and controversy in candidacy proposal for the second term of constitutional justices. This term of office needs to be changed with a longer time length without extension combined with the retirement age. The determination of the term of office of constitutional justices which is related to the judicial independence cannot be separated from the requirements, selection, supervision, and dismissal of constitutional justices. Those requirements, mechanisms for selection, supervision, and dismissal of constitutional justices also need to be improved. AbstrakHakim konstitusi memiliki periode masa jabatan lima tahun dan dapat dipilih kembali hanya untuk satu kali masa jabatan berikutnya. Ketentuan ini telah coba dikoreksi melalui permohonan uji materi terhadap UU Mahkamah Konstitusi (MK), tetapi tidak ada putusan MK yang menyatakan periode masa jabatan hakim konstitusi bertentangan dengan UUD NRI Tahun 1945. Tulisan ini menganalisis mengenai perlunya reformulasi ketentuan mengenai periode masa jabatan hakim konstitusi dikaitkan dengan prinsip kemandirian kekuasaan kehakiman. Analisis mengenai periode masa jabatan hakim konstitusi juga dilakukan dengan membandingkan prinsip internasional dan praktik di negara lain. Periode masa jabatan 5 tahun dan dapat dipilih kembali memiliki kelemahan, karena membuka peluang pengaruh politik dan kontroversi pada pengajuan calon hakim konstitusi periode kedua. Periode masa jabatan ini perlu diubah dengan masa jabatan yang lebih lama tanpa perpanjangan dikombinasikan dengan usia pensiun. Penentuan periode masa jabatan hakim konstitusi yang dikaitkan dengan kemandirian kekuasaan kehakiman tidak dapat lepas dari persyaratan, seleksi, pengawasan, dan pemberhentian hakim konstitusi. Persyaratan, mekanisme seleksi, pengawasan, dan pemberhentian hakim konstitusi juga perlu disempurnakan.
MOOCs sobre tecnologia assistiva no contexto educacional: uma revisão sistemática
Authors: Poletto Salton Bruna , Bertagnolli Silvia 
Published: May 2021

Para muitos estudantes com deficiência, o acesso a recursos e serviços de Tecnologia Assistiva (TA) pode ser o diferencial para que tenham autonomia e êxito no contexto educacional. Para viabilizar essa realidade, há demanda crescente por capacitação em TA que chegue até os envolvidos nesse processo, de forma ampla, aberta e gratuita, características estas que podem ser contempladas pela oferta de Massive Open Online Courses (MOOCs). Nesse sentido, foi conduzida uma revisão sistemática para prover uma visão geral do estado corrente da pesquisa relacionada à utilização de MOOCs para oferecer capacitação em TA no contexto educacional. Como resultados, verificouse a quase inexistência de MOOCs sobre TA e que o tema ainda é pouco explorado, mas com grande potencial para atender uma demanda urgente e crescente no contexto educacional.
Desenvolvimento de Jogos Educacionais Digitais: um Relato de Experiência com o Framework PlayEduc
Authors: Ferreira Aires Samanta , Andryê Galvão Madeira Charles 
Published: May 2021

Os jogos educacionais digitais vêm ganhando espaço como alternativa paraauxiliar no processo de ensino e aprendizagem, mas a qualidade deles depende tanto da forma em que são concebidos quanto da forma em que são aplicados. Por isso, diversas ferramentas têm sido desenvolvidas para permitir avaliar a qualidade dos mesmos em vários aspectos. No entanto, ainda são poucas as ferramentas existentes direcionadas à etapa de concepção, de modo que os jogos venham a ser desenvolvidos da forma mais adequada. Este artigo relata um exemplo de aplicação do framework PlayEduc ao longo do processo de desenvolvimento de um jogo educacional digital por uma equipe multidisciplinar. O objetivo desta aplicação foi avaliar o quanto os princípios do PlayEduc auxiliam à equipe envolvida. Os resultados obtidos são bastante promissores.
Um Estudo Terciário Sobre o Ensino de Computação no Brasil
Authors: Natan Paschoal Leo , Henrique Dias Valle Pedro , M. Melo Silvana 
Published: May 2021

O ensino de computação tem ganhado espaço em conferências e períodicos brasileiros que envolvem tecnologias educacionais. Nesse contexto, têm sido discutidas abordagens e mecanismos para apoiar (i) iniciativas que visam desenvolver o pensamento computacional, (ii) movimentos que visam promover mulheres na computação e (iii) problemas que emergem no contexto de ensino de disciplinas de Computação. Nessa perspectiva, estudos secundários vêm sendo produzidos, com o propósito de sintetizar as contribuições já estabelecidas. Apesar disso, não há um panorama sobre quais os tópicos sobre o ensino de Computação já foram investigados, bem como os problemas inerentes a esses tópicos e suas soluções. Nesse sentido, este artigo aborda um estudo terciário, visando contribuir com essa temática, por meio de uma análise das evidêencias sobre os tópicos abordados em ensino de Computação, os principais problemas e soluções propostas.
Molecular profiling of congenital glioblastoma using a next-generation sequencing panel
Authors: Corrêa Débora Cabral de Carvalho , Tesser-Gamba Francine , Silva Nasjla da , Capellano Andrea , Alves Maria Teresa , Dastoli Patrícia , Costa Marcos Devanir da , Cavalheiro Sergio , Toledo Silvia 
Published: May 2021

Background Congenital GBM (cGBM), presenting prenatally or
within the first months of life, is among the rarest type of congenital
brain tumor, with approximately 120 cases reported. Due to its
infrequent occurrence, few studies have focused on the molecular and
genetic aspects of this tumor, and the mutational events involved in the
pathogenesis and progression of cGBM still remains poorly understood.
This study aimed to investigate molecular alterations, with a potential
prognostic marker and therapeutic target in cGBM using the
next-generation sequencing (NGS) strategy. Methods We selected
seven tumor samples from patients diagnosed with cGBM and treated at
Pediatric Oncology Institute-GRAACC/UNIFESP. NGS was performed to
identify somatic genetic variants in tumor samples using the Oncomine
Childhood Cancer Research Assay panel, from
ThermoFisher Scientific, designed specifically for
pediatric neoplasms. Results Of all seven patients analyzed,
three patients exhibited tumors with genetic variants, which include two
pathogenic variants in NF1 and SUZ12 genes that have not
been reported in cGBM yet, an increase in the number of copies
of ALK gene, and two gene fusions, PPP1CB-ALK
and TPM3-NTRK1. Also, none of the cases showed variants
in H3F3A, TP53 and ATRX genes, alterations which
are frequently seen in pediatric and adolescent
GBM. Conclusions Our results suggest that cGBM may comprise a
unique tumor entity and alterations in ALK and NTRK genes
provide a potential target for therapy. Therefore, identification of
genetic variants in cGBM is highly relevant in order to define prognosis
and therapeutic strategies.