bluuebunny/crossref_metadata_2025_split huggingface dataset:
How budget trade‐offs undermine electoral incentives to build public housing
Authors: Hilbig Hanno , Wiedemann Andreas 
Published: December 2024

AbstractHousing shortages and rising rents have increased demands for affordable housing. In this paper, we examine whether electoral constraints can undermine local politicians' incentives to build public housing. Empirically, we draw on the full‐count census of all housing built in Germany, data on 19,685 local elections between 1989 and 2011, and an original survey. Using a difference‐in‐differences design, we demonstrate that incumbents are not rewarded, but rather experience moderate electoral losses after constructing new public housing. We then show that these losses are not primarily driven by homeowner opposition or native–foreigner competition. Instead, electoral punishment is largest in economically disadvantaged municipalities with relatively affordable housing, as voters prioritize spending in other local policy areas that are crowded out by public housing. Survey evidence demonstrates that electoral constraints emerge when voters' short‐term spending preferences conflict with municipalities' long‐term goals to provide affordable housing.
A systematic review and meta‐analysis of interventions to delabel low‐risk penicillin allergies with consideration for sex and gender
Authors: Maximos Mira , Pelletier Ryan , Elsayed Sameer , Maxwell Colleen J. , Houle Sherilyn K. D. , McConnell Brie , Gamble John‐Michael 
Published: December 2024

AbstractAimsSex and gender may influence penicillin allergy label (PAL) prevalence and outcomes. This review evaluates the effectiveness and safety of direct delabelling (DD) and oral challenge (OC) for low‐risk patients and examines sex and gender differences in reporting and outcomes.MethodsWe searched PubMed, Database of Abstracts of Reviews and Effects, ClinicalTrials.gov, Cochrane Database of Systematic Reviews, International Pharmaceutical Abstracts, medRxiv, Ovid MEDLINE, and Ovid EMBASE until February 2024 for studies including DD or OC compared to no intervention, skin testing or other methods. Two reviewers assessed quality. Meta‐analyses were conducted, and subgroup analyses were carried out if I2 >   75%. Descriptive data was analysed using NVivo 14 and reported narratively.ResultsFrom 1046 screened studies, 28 met inclusion criteria (two RCTs, 26 quasi‐experimental studies). Sex at baseline was reported in 86% of studies, with 61% females: 18% disaggregated outcomes by sex with a female mean delabelling rate of 66%. Gender variables were not reported. OC was not found to be more or less as effective comparaed to skin testing in RCTs (risk ratio [RR] 1.04; 95% confidence interval [CI] 0.95, 1.13, I2 = 74%). DD interventions had a 27% delabelling rate (95% CI 10%, 50%, I2 = 96%), with nursing staff achieving 29% (95% CI 15%, 47%, I2 = 63%) and allergists/immunologists 6% (95% CI 0.00, 0.00, I2 = 20%). Quasi‐experimental studies reported 90% delabelling for OC, with 59% by allergists/immunologists and 90% by pharmacists. Adverse events averaged 4% and were non‐severe.ConclusionsDD and OC are effective for delabelling low‐risk penicillin allergies. Comprehensive data is lacking on sex and gender differences, indicating a need for further research.
Landscape of somatic mutations and clonal evolution in NUP98‐rearranged adult acute myeloid leukaemia
Authors: Frerich Candace , Li Peng , Raess Philipp W. , Dunlap Jennifer , Lachowiez Curtis , Solis‐Ruiz Jose , Press Richard , Long Nicola , Swords Ronan T. , Wiszniewska Joanna , Fan Guang , Xie Wei 
Published: December 2024

SummaryAcute myeloid leukaemia with NUP98 rearrangement (AML‐NUP98) has been previously described in paediatric patients, and the clinical significance in adult AML patients remains largely unexplored. In this study, we identified specific partner fusion genes and examined somatic co‐mutations and clonal evolution longitudinally in adult AML‐NUP98 patients. Our comprehensive analysis provides an understanding of NUP98 rearrangement and co‐mutations influencing clonal evolution and disease progression and offers valuable insights into potential therapeutic strategies. Further multiple centre studies are needed to investigate this entity in adult patients and improve treatment strategy.
“It's not being ‘on‐the‐land,’ it's like we are a part of the Land”: Indigenous youth share visual stories at “on‐the‐land” camps in the Dehcho
Authors: Woodworth Steph , Tanche Kristen , Nadli Britney , Wesche Sonia D. , Spring Andrew 
Published: December 2024

AbstractIn northern Canada, Indigenous Peoples face rapid environmental and sociocultural changes that disrupt access to traditional places and practices. This disruption limits cross‐generational knowledge transfer and decreases opportunities for youth to connect with the Land. Land‐based education programs aim to provide Indigenous youth with spaces to learn about and connect with the Land, their language, and culture. However, there is limited research on what youth experience, enjoy, and learn during these programs. Our paper explores this through a study with Dene and Métis youth in the Dehcho region of the Northwest Territories. We investigate what youth experience and learn during “on‐the‐land” camps and how these camps provide spaces for youth to connect with the Land. Using a community‐based, Indigenous research methodology, we employed photovoice, allowing youth to share visual stories of their camp experiences and their (re)connection with the Land. Our results are categorized into three themes: (1) connections with the Land; (2) enjoyment of the camp environment; and (3) land‐based learning. We argue that land‐based education programs, such as on‐the‐land camps, are effective for fostering relationships between Indigenous youth and the Land. These camps teach youth various ways to connect with and protect the Land for future generations.
Building Capacity for Digital Innovation—A Game‐Study
Authors: Madsen Kristina Maria , Brix Jacob 
Published: December 2024

ABSTRACTOrganizations are facing a constant stream of emerging technologies that require management and staff to be more flexible, open and critical in exploring new potential. In supporting new digital innovation, an organization will inevitably be affected on the level of strategy, business design and operation. In this paper, we explore games' potential as one approach for building digital innovation capacity in an organization since games have been proven beneficial in early innovation and learning processes. Theoretically, we focus on ‘building digital innovation capacity.’ This is understood as a process where the knowledge about digitalization and digital transformation is used to strengthen individuals' skills, abilities and opportunities—knowledge that can be used as a source for organizational learning and development. In this paper, we explore and discuss the role of games in building capacity for digital innovation in established organizations through an empirical study consisting of four game sessions with the game Cards for IoT. Overall, this game study implies three important themes concerning games' role in building capacity for digital innovation in established organizations: gameplay & facilitation, player mindset and contextualization. The perspectives, nuances and insights of the themes are discussed with the literature on capacity building.
Information Governance: Paving the Way to Digital Institutions and Organizations
Authors: Caron Daniel J. 
Published: December 2024

AbstractAdvances in ITCs features have been putting our institutions and organizations under sustained pressure for several years. Based on concrete examples, this article first recalls the nature of the issues at stake and raises the importance of reconsidering our ways of organizing our bureaucracies based on the central role of information. The main responses provided so far are analyzed in the light of this shortcoming in the processing of information, which is often overlooked. Then, democratic principles and values are discussed as guidelines to be respected to avoid a techno‐centric drift. Finally, the importance of understanding the meaning and implications of the digital transformation, the need to consider the organization from the perspective of information processing, and the implementation of information governance are addressed as the three cornerstones of the digital transformation. The text concludes with a series of proposals to be considered to achieve this.
In Silico‐Designed G‐Quadruplex Targeting Peptide Attenuates VEGF‐A Expression, Preventing Angiogenesis in Cancer Cells
Authors: Banerjee Nilanjan , Roy Laboni , Panda Suman , Roychowdhury Tanaya , Chatterjee Subhrangsu 
Published: December 2024

ABSTRACTVascular endothelial growth factor‐A (VEGF‐A) is a growth factor and pluripotent cytokine that promotes angiogenesis in cancer cells, transitioning to an angiogenic phenotype. The binding of VEGF‐A protein to VEGF receptors (VEGFR‐1 and VEGFR‐2) initiates a cascade of events that stimulates angiogenesis by facilitating the migration and enhancing the permeability of endothelial cells. The proximal promoter of the VEGF gene encompasses a 36‐base pair region (from −85 to −50) that can form a stable G‐quadruplex (G4) structure in specific conditions. The activity of the VEGF promoter is reliant on this structure. During cancer progression, the VEGF‐A G4 succumbs to cellular pressure and fails to maintain a stable structure. This shifts the balance to form a duplex structure, increasing the transcription rate. Earlier research has tried to develop small‐molecule ligands to target and stabilise G4, demonstrating the possibility of suppressing VEGF expression. However, they either lack specificity or toxic. Peptides, on the other hand, are significantly less studied as G4 binders. Here, we designed a peptide that successfully binds and stabilises the VEGF‐A G4 while reducing its gene expression. This further alters the expression fate of the VEGF‐A signalling cascade and blocks angiogenesis in cancer cells. We employed high‐resolution nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics simulation to elucidate the chemical details of G4‐peptide interaction. In addition, we used qPCR and western blot techniques to investigate the expression pattern of the molecules implicated in the VEGF‐A signalling cascade. The study explores the intricate relationship between peptides and quadruplex structures, revealing valuable insights that can improve the design of pharmacophores targeting the dynamic quadruplex structure. The results of our study are encouraging, opening possibilities for advancements in, the characterisation and optimisation of peptides as G‐quadruplex ligands in view of their potential therapeutic uses.
Enhancing lymphoscintigraphic specificity of lymphoedema diagnosis in patients with lipoedema
Authors: Amiel Hadrien , Coulie Julien , Georis Raphaël , van la Parra Raquel , Pirson Genevieve , Deconinck Christine 
Published: December 2024

SummaryThis study addresses the diagnostic challenges of identifying lymphoedema in patients with lipoedema using lymphoscintigraphy. Overdiagnosis of lymphoedema in this patient population is frequent and may result in reduced proposed surgical interventions. We retrospectively analyzed clinical data from patients followed for lipoedema, lymphoedema or lipolymphoedema and who underwent lymphoscintigraphy. All patients were assigned a clinical or lymphoscintigraphic diagnosis of lymphoedema and concordance between clinical and lymphoscintigraphic diagnosis was assessed. A modification of lymphoscintigraphic criteria interpretation was proposed to enhance the diagnosis specificity. We included 94 female patients (188 lower limbs). One hundred and thirty‐seven limbs presented with signs of lipoedema (137/188; 72.9%) and 42 with clinical signs of lymphoedema (42/188; 22.3%). Overall, 125 limbs presented with a diagnosis of lymphoedema on lymphoscintigraphy (125/188; 66.5%). Using lymphoscintigraphy to diagnose lymphoedema in patients with lipoedema resulted in low specificity (38.3%). By adjusting the interpretation criteria of the lymphoscintigraphic anomalies, we could achieve a specificity of 80.85%, reducing the risk of overdiagnosing lymphoedema in patients with lipoedema. This study contributes to the ongoing efforts to optimize the assessment and management of patients with lipoedema and potential lymphatic involvement, by modifying the interpretation of lymphoscintigraphic criteria.
Effect of the SGLT2 inhibitor ipragliflozin on the expression of genes that regulate skin function
Authors: Ikarashi Nobutomo , Tabata Keito , Shinozaki Yui , Kon Risako , Sakai Hiroyasu , Hosoe Tomoo 
Published: December 2024

AbstractAimsSkin disorders occur more frequently with sodium‐dependent glucose cotransporter type 2 (SGLT2) inhibitors than with other antidiabetic drugs. We conducted basic research using ipragliflozin, with the aim of identifying new measures to prevent skin disorders caused by SGLT2 inhibitors.Methodsdb/db type 2 diabetes model mice were orally administered ipragliflozin (10 mg/kg or 30 mg/kg) once a day for 28 days and skin function genes were analysed by real‐time RT‐PCR or Western blotting.ResultsNo difference in the expression level of collagen (Col1a1 and Col1a2) in the skin was detected between the ipragliflozin treatment group and the control group. On the other hand, the expression levels of enzymes involved in the synthesis and decomposition of hyaluronic acid (Has2 and Hayl1) and enzymes involved in the synthesis and decomposition of ceramide (Sptlc1, Sptlc2, Asah1, and Acer1) were significantly decreased by the administration of ipragliflozin. Furthermore, the expression levels of filaggrin (Flg), loricrin (Lor), elastin (Eln), and aquaporin‐3 (Aqp3) in the skin were lower in the ipragliflozin treatment group than in the control group.ConclusionsIt was revealed that ipragliflozin reduces the expression of genes involved in skin barrier and moisturizing functions, which this may be one of the mechanisms through which this drug causes skin disorders.
Applying the Quadrant Method for Pumping‐Trace Metal Correlations in Variable Time, Low‐Data Systems
Authors: Tomlinson Zachary D. , Dee Kato T. , Madden Megan E. Elwood , Madden Andrew S. Elwood 
Published: December 2024

AbstractDue to increasing global demand for fresh water, it is increasingly necessary to understand how aquifer pumping affects groundwater chemistry. However, comprehensive predictive relationships between pumping and groundwater quality have yet to be developed, as the available data, which are often collected over inconsistent time intervals, are poorly suited for long‐term historical correlation studies. For example, we needed an adequate statistical method to better understand relationships between pumping rate and water quality in the City of Norman (OK, USA). Here we used the interval‐scaled change in mean pumping rate combined with the Quadrant method to examine correlations between pumping rates and changes in trace metal concentrations. We found that correlations vary across the study area and are likely dependent on a variety of factors specific to each well. Comparing the Quadrant method to the commonly used Kendall's tau correlation, which requires different assumptions about aquifer behavior, the methods produced similar correlations when sample sizes were large and the time interval between samples was relatively short. Sample sizes were then artificially restricted to determine correlation reproducibility. Despite being less reproducible overall, the Quadrant method was more reproducible when there were large time intervals between samples and very small sample sizes (n ~ 4), but not as reproducible as significant (p ≤ 0.1) Kendall's tau correlations. Therefore, the Quadrant method may be useful for further investigating the effects of pumping in cases where Kendall's tau does not produce significant correlations.
Ossifying fibromyxoid tumours with lipomatous and cartilaginous differentiation: A diagnostic pitfall
Authors: Klubíčková Natálie , Billings Steven , Dermawan Josephine K T , Molligan Jeremy F , Fritchie Karen 
Published: December 2024

AimsOssifying fibromyxoid tumour is a rare mesenchymal neoplasm predominantly affecting adults characterised by a multinodular growth pattern and the presence of a fibrous pseudocapsule with areas of ossification. Prompted by the recognition of a non‐ossifying ossifying fibromyxoid tumour with lipomatous differentiation which caused diagnostic difficulty, we sought to further explore cases of ossifying fibromyxoid tumour with non‐osseous heterologous elements.Methods and ResultsA search of our institutional and consultation archives revealed three additional cases that demonstrated lipomatous components and two cases with cartilaginous differentiation. RNA‐sequencing revealed fusions involving PHF1 (n = 4) or EPC1 (n = 1) in all (five of five) cases tested, including EPC1::PHC1 and JAZF1::PHF1 fusions, which have not been reported before in ossifying fibromyxoid tumour.ConclusionThese six cases expand the histomorphological spectrum of ossifying fibromyxoid tumour, introducing lipomatous differentiation as a hitherto undocumented feature. Awareness of these rare variants will ensure appropriate diagnosis and clinical management.
Immunogenicity and Safety of AS03‐Adjuvanted H7N9 Influenza Vaccine in Adults (18–64 and ≥65 Years): A Phase 1/2, Randomized, Placebo‐Controlled Trial
Authors: Hastie Andrew , Clarke Tanya , Germain Sophie , Ollinger Thierry , Lese Patricia , Gupta Vinay 
Published: December 2024

ABSTRACTBackgroundInfluenza A/Hong Kong/125/2017 (H7N9) virus poses a pandemic risk owing to its evolving nature. This study evaluated the immunogenicity and safety of an AS03‐adjuvanted H7N9 vaccine in adults (18–64 years [younger] and ≥65 years [older]).MethodsParticipants (younger, n = 418; older, n = 420) were randomized to receive one of six adjuvanted vaccines (hemagglutinin [1.9 μg, 3.75 μg, and 7.5 μg] with AS03A or AS03B) or placebo. The co‐primary objectives were to determine whether the adjuvanted vaccines elicit an immune response against the vaccine‐homologous virus 21 days after the second vaccine dose and to evaluate the safety of the vaccines.ResultsH7N9 AS03‐adjuvanted vaccines at various doses showed a humoral immune response but failed to meet CBER immunogenicity criteria. However, a trend of increased immune responses was observed with the AS03A adjuvant versus the AS03B adjuvant, particularly in older adults. In both age groups, injection site pain and fatigue occurred more frequently with adjuvanted vaccines. No reported serious adverse events were vaccine‐related.ConclusionsThis study did not achieve its primary objective at any dose level. The modest immune response to AS03‐adjuvanted vaccines, consistent with other studies using similar antigens, highlights the need for continued research for H7N9 pandemic preparedness.Trial Registration: NCT04789577 [ClinicalTrials.gov]
Programme Recipient and Facilitator Experiences of Positive Family Connections for Families of Children With Intellectual Disabilities and/or Who Are Autistic
Authors: Sutherland Daniel , Flynn Samantha , Griffin Joanna , Hastings Richard P. 
Published: December 2024

ABSTRACTBackgroundFamily members of children with developmental disabilities on average report poorer family functioning and mental health. Positive Family Connections is a co‐produced, positively‐oriented, family‐systems support programme for families of children with developmental disabilities aged 8–13. We investigated experiences of Positive Family Connections, and the processes involved in change.MethodWe conducted semi‐structured interviews with eight family carers who took part in Positive Family Connections and nine facilitators. Data were analysed using framework analysis.ResultsProgramme recipients' and facilitators generally reported positive experiences of Positive Family Connections and described beneficial effects on wellbeing and family relationships. We developed a model showing how the lived experience of facilitators and positive approach led to reductions in isolation and perceived changes in mindset that were described as improving family carers' wellbeing and family relationships.ConclusionsPositive Family Connections appears to be an acceptable programme which programme recipients and facilitators perceive to be beneficial.
Cadê o Kauê? Co‐design and acceptability testing of a chat‐story aimed at enhancing youth participation in the promotion of mental health in Brazil
Authors: Pavarini Gabriela , Murta Sheila Giardini , Mendes Josimar Antônio de Alcântara , Siston Felipe Rodrigues , de Souza Rafa Ribeiro Alves , de Oliveira da Cunha Rafaela , Alves Ferreira Julyana , de Santos Victor Hugo de Lima , Seabra Brenda Thallys Rocha ,   Talk2U, Singh Ilina 
Published: December 2024

BackgroundAdolescent mental health is vital for public health, yet many interventions fail to recognise adolescents as proactive community contributors. This paper discusses the co‐design and acceptability testing of a chat‐story intervention to enhance Brazilian adolescents' participation in the promotion of mental health in their peer communities. We specifically highlight the iterative process of co‐creating this intervention with community stakeholders.MethodsThe co‐design was led by researchers, a youth collaborative group, and health‐tech experts. Part 1 included quantitative (n = 1,768) and qualitative (n = 46) studies with Brazilian adolescents aged 15–18 for priority‐setting. Part 2 involved co‐creation and technical production, with input from youth advisors (n = 24), school staff (n = 11), and policy experts (n = 3). In Part 3, the chat‐story was user tested (n = 32). Parts 4 and 5 assessed acceptability through a qualitative study in schools (n = 138) and initial efficacy during an online campaign (n = 795).ResultsParticipants aspired to support their peers' mental health in schools, both one‐to‐one and collectively, but felt unprepared. This informed the chat‐story's goal of enhancing peer support and collective action skills. Themes identified during Part 1, such as prejudice and academic pressure, were woven into the narrative to raise awareness of the social determinants of mental health, drawing from real‐life stories. In the final story, players search for their missing best friend at school, uncovering his anxiety struggles and practicing skills such as empathic listening and partnership building. A manual for teachers was collaboratively designed for use within school settings, supplementing direct‐to‐user online applications. Acceptability testing showed participants found the tool authentic and user‐friendly. Online users perceived the tool as preparing and motivating them to offer peer support and engage in collective action.ConclusionsThe immersive co‐creation model, enriched by input from key stakeholders, yielded a relevant and well‐received intervention for Brazilian adolescents. Co‐designed creative tools like chat‐stories hold promise as digital mental health tools, fostering awareness, critical reflection, and inspiring adolescents to drive positive social change.