bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cerebral mechanism of Tuina for treating knee osteoarthritis pain: study protocol for a randomized controlled parallel trial
Authors: Xu Hui , Xiao Lianbo , Zhao Chi , Xie Yuchen , Kang Bingxin , Xu Xirui , Xinyu A , Xie Jun 
Published: November 2021

Abstract
Background: Despite the high prevalence and socioeconomic impact of knee osteoarthritis (KOA), treatments for KOA are often unsatisfactory, with wide variation in effectiveness across patients. Tuina is one treatment that is frequently prescribed for patients with KOA. However, how Tuina influences the activity of the central nervous system to alleviate KOA pain remains unclear. Our randomized controlled parallel trial was designed to address this gap through a comparative evaluation of the effect of Tuina on the resting-state functional connectivity (rsFC) of the brain in patients with KOA compared to treatment using celecoxib as the control.Methods/design: This will be a randomized controlled parallel trial to be conducted between June 2022 and June 2024. Forty-eight participants with KOA will be enrolled and randomly allocated to one of two groups, the Tuina treatment group or the celecoxib (control) group. Participants in each of the two groups will undergo 6 weeks treatment. Resting-state functional magnetic resonance imaging (fMRI) will be performed to quantify rsFC at baseline, before treatment, and at the end of the intervention, where rsFC will be used to evaluate the effects of treatment on brain activity. The following self-reported scales will be used as clinical measures of symptomology: the Numerical Rating Scale to quantify the severity of pain, the Pain Catastrophizing Scale to quantify emotional response to pain, and the Hamilton Anxiety Scale and the Hamilton Depression Scale to quantify the cognitive response to pain. Scale scores will be obtained before and after treatment to measure clinical change. Adverse events will be documented and assessed throughout the trial.Discussion: The results of our trial will provide evidence of the effect of Tuina treatment on the rsFC of patients with KOA and identify the possible relationship between a change in the rsFC and improvement of clinical variables, thus elucidating the central mechanism by which Tuina improves pain in KOA.Trial registration: Registered in the Chinese Clinical Trial Registry (http://www.chictr.org.cn/searchproj.aspx, ChiCTR2100045990). Date of registration: 1 May 2021.
Inferior Vena Cava Filter Thrombosis Associated with a Free-Floating Thrombus on a Retrieval Hook: A Case Report and Literature Review
Authors: Duan Ruihua , Li Weihao , Liu Min , Bai Chenhui , Wang Fangjun , Lin Yisheng 
Published: November 2021

Abstract
Background: It has been widely reported that IVCFT is a type of thrombotic disease. However, there are very few case reports regarding free-floating thrombi on retrieval hooks.Case presentation: This case report describes inferior vena cava filter thrombosis (IVCFT) associated with a free-floating thrombus on a retrieval hook in a 26-year-old male. Rotational digital subtraction angiography (RDSA) was used for the diagnosis and a second retrievable filter was placed above the original filter to prevent detachment of the thrombi. Catheter-directed thrombolysis (CDT) and aspiration thrombectomy (AT) were used to treat the thrombosis, and both filter retrievals were performed successfully.Conclusions: Attention should be paid to the diagnosis and endovascular procedures of a free-floating thrombus on a retrieval hook. In the event of thrombosis, the therapeutic effect and safety level can be increased through CDT combined with AT.
Bilateral Synchronous 3-port Transperitoneal Laparoscopic Ureterolithotomy: A Case Report
Authors: Kumar Bharath N 
Published: November 2021

Abstract
Transperitoneal laparoscopic ureterolithotomy is a well-established minimally invasive procedure for management of large impacted ureteric stones since the last 3 decades. We present a case of a 51 years old gentleman, who presented with bilateral large upper ureteric calculi with obstructive uropathy and azotemia, managed successfully with bilateral synchronous 3-port transperitoneal laparoscopic ureterolithotomy, and to our knowledge is the first such case to be reported in literature.
Key Regulatory Pathways, MicroRNAs, and Target Genes Participate in Adventitious Root Formation of Acer Rubrum L
Authors: Zhu Wenpeng , Zhang Manyu , Li Jianyi , Zhao Hewen , Zhang Kezhong , Ge Wei 
Published: November 2021

Abstract
BackgroundAcer rubrum L. is a colorful ornamental tree with great economic value. Because this tree is difficult to root under natural conditions and the seedling survival rate is low, vegetative propagation methods are often used. Because the formation of adventitious roots (ARs) is essential for the survival of asexual propagation of A. rubrum, it is necessary to investigate the molecular regulatory mechanisms in the formation of ARs of A. ruburm. To address this knowledge gap, we sequenced the transcriptome and sRNA of the A. rubrum variety ‘Autumn Fantasy’ using high-throughput sequencing and explored changes in gene and microRNA (miRNA) expression in response to exogenous auxin treatment. ResultsWe identified 82,468 differentially expressed genes between the treated and untreated ARs, as well as 48 known and 95 novel miRNAs. We also identified 172 target genes of the known miRNAs using degradome sequencing. Two regulatory pathways (ubiquitin mediated proteolysis and plant hormone signal transduction), Ar-miR160a and the target gene ArARF10 were shown to be involved in the auxin response. We further investigated the expression patterns and regulatory roles of ArARF10 through subcellular localization, transcriptional activation, plant transformation, qRT-PCR analysis, and GUS staining. ConclusionsDifferential expression patterns indicated the Ar-miR160a-ArARF10 interaction might play a significant role in the regulation of AR formation in A. rubrum. Our study provided new insights into mechanisms underlying the regulation of AR formation in A. rubrum.
All-optical logic gates using a plasmonic MIM waveguide and elliptical ring resonator
Authors: Haffar Rida El , mahboub oussama , Farkhsi Abdelkrim , Figuigue Mustapha 
Published: November 2021

Abstract
All - optical logic gates OR, XOR, AND and NOT based on two - dimensional ( 2D ) plasmonic metal - insulator - metal ( MIM ) coupled with Elliptical Ring Resonator ( ERR ) are presented , simulated and investigated by using the numerical method of the FEM (finite elements method ). The results are compared and validated with the finite difference time domain ( FDTD ) method . The proposed logic gates are achieved with the same structure using the constructive and destructive optical interferences between a control signal and input signal(s). Their characterization was mainly done for two spectral regions , visible and near - infrared . A high intensity contrast ratios (CR) between the logic states ( “1” and “0” ) can be achieved (28 dB ) at these spectral regions . We introduce a new parameter , "gap- threshold ratio ( GTR )", to characterize the gap between the maximum and minimum of the transmitted signal intensity for all logic gates. The suggested value of transmission threshold between logic 0 and logic 1 states is T th =0.2 . A comparison of the two parameters , (CR) and ( GTR ), with previous works shows that the proposed structure gives very good results for all logic gates configurations. The proposed all- optical logic gates configuration can be a key components in optical processing and telecommunication devices .
An Investigation on M-Polar Fuzzy Saturation Graph and Its Application
Authors: MAHAPATRA TANMOY , Pal Madhumangal 
Published: November 2021

Abstract
The saturation graph is a well-defined topic. But, saturation in a fuzzy graph was de ned recently and investigated many properties. In a fuzzy saturation graph, only one saturation is considered for every vertex. In a m-polar fuzzy graph (mPFG), each vertex and edge has a m number of membership values. So, defining saturation for mPFG is not easy and needs some new ideas. By considering m saturation for each component out of m components of membership values of a vertex, we defined saturation in mPFG. α-saturation as well as β-saturation in mPFG is introduced here. Many interesting properties of it are also presented. α-vertex count and β-vertex count in mPFG are also studied and the upper bound on some well known mPFG is also found here. Finally, a real-life application using saturation in mPFG is also presented.
Facile Synthesis of Crosslinked Cu:ZnS-Lignocellulose Nanocomposite: A Potent Antifungal and Antisporulant System Against The Tea Pathogen Exobasidium Vexans
Authors: Chaliha Chayanika , Baruah Julie , Kalita Eeshan 
Published: November 2021

Abstract
The objective of the present study was to synthesize Cu doped ZnS nanocore crosslinked with lignocellulose (represented as Cu:ZnS-lignocellulose nanocomposite) for antifungal action against the devastating tea blister blight pathogen Exobasidium vexans. The characteristic features of the nanocomposite were analyzed via different physicochemical techniques like FTIR, XRD, XPS, SEM, SEM-EDX, Elemental mapping, PCS, and UV-PL studies. The FTIR and XPS investigations revealed the crosslinking between lignocellulose and the Cu:ZnS. The presence of lignocellulose was seen to attribute a potent antifungal efficacy, also enhancing the stability of the resulting nanocomposite in aqueous suspensions. The antifungal efficacy confirmed through disk diffusion and broth dilution assays have a maximum zone of inhibition of 1.75 cm2 and a MIC50 of 0.05 mg/ml against E. vexans. Additionally, the antisporulant activity was evident as the basidiospores failed to germinate in presence of the Cu:ZnS-lignocellulose nanocomposites. This shows potential for stemming the rapid infectivity of E. vexans by achieving disease inhibition at the early stage. Finally, the comparison with two commonly used commercial fungicides (copper oxychloride and fluconazole) demonstrated > 10-fold higher antifungal activity for Cu:ZnS-lignocellulose nanocomposites.
The Variabilities of Convective Precipitation and Large-scale Precipitation in Southern China under Global Warming
Authors: zhang han , Zhao Junhu , Huang Bicheng , Zang Naihui , Yang Jie , Guolin Feng 
Published: November 2021

Abstract
In this paper, the spatial and temporal characteristics of convective precipitation (CP) and large-scale precipitation (LSP) in southern China during 1980-2020 are analyzed using monthly mean precipitation data from MERRA-2. In addition, the possible effects of relative humidity on CP and LSP are explored. The results indicate the following. (1) The LSP dominates the proportion of total precipitation (TP). Both LSP and CP are more prevalent in the south and less prevalent in the north, but there is a difference in the regions of their maximum centers. (2) Significant interannual and seasonal variations are observed in precipitation. TP and LSP tended to be higher than average after the 1990s, while for the CP, a negative trend has dominated the past years with considerable fluctuation. There are obvious increasing trends for TP and LSP, with area-averaged linear trends of 7.0 mm/year and 8.9 mm/year, respectively, while that of CP is -1.9 mm/year. The increasing trends of LSP are mainly contributed by the precipitation of summer and autumn. (3) The variations of LSP are affected by relative humidity in the troposphere, while CP is only influenced by the changes in relative humidity due to air temperature or specific humidity. The trend of relative humidity is -0.32%/decade, mainly due to rising temperature in the troposphere. (4) Changes in specific humidity caused by temperature or specific humidity alone act on large-scale precipitation through both interannual and interdecadal processes, causing large-scale precipitation to increase. And the convective precipitation is mainly affected by the interdecadal processes.
Does intestinal peristalsis cause suture failure after instrument suture?
Authors: Rino Yasushi , Maezawa Yukio , Aoyama Toru , Atsumi Yosuke , Kazama Keisuke , Numata Masakatsu , Tamagawa Hiroshi , Sato Tsutomu , Yamada Takanobu , Oshima Takashi , Yukawa Norio , Masuda Munetaka 
Published: November 2021

Abstract
Introduction Gastrectomy with lymphadenectomy is a standard treatment for gastric cancer. Anastomotic leakage remains a potentially fatal complication of gastrectomy. Forceful stapler extraction may cause anastomotic complications. We focused on the duodenal peristalsis, as we hypothesized that it might cause forceful stapler extraction. We then retrospectively investigated duodenal peristalsis. We reviewed videos of Da Vinci system cases to clarify the relationship between peristalsis and anastomotic complications. Methods Forty-nine cases with stored videos of laparoscopic surgery using the Da Vinci system from 2015 to March 2021 were included. Peristalsis was defined by repeated contraction and expansion that was clearly visible three or more times in a row, and that there was no peristalsis in other cases. We investigated the duodenum because it is frequently observed during gastrectomy. We evaluated suture failure in cases with and without peristalsis. Results The study population included 49 patients (male, n=32; female, n=17; median age, 71 [42-82] years). Duodenal peristalsis was observed in 14 (28.6%) cases. Three patients experienced complications. A comparative study of cases with and without complications showed significant peristalsis in cases with complications (p=0.0198). Discussion Anastomotic leakage remains a serious and potentially fatal complication of gastrectomy, and surgeons should make efforts to prevent anastomotic leakage. Various risk factors associated with anastomotic leakage have been reported. This is the first retrospective study to evaluate duodenal peristalsis during gastrectomy for gastric cancer. We hypothesized that duodenal peristalsis would apply extreme tension on the stapler. Peristalsis would twist and increase the pressure on the stapler. In this study, we defined a new scale to evaluate duodenal peristalsis. Anastomotic complications were significantly more frequent in cases with peristalsis (p=0.0198). Our results suggest the utility of manual over-sewing or the use of reinforcement material.
Patient Reported Outcomes in Penile Cancer
Authors: Youssef Irini , Hoogland Aasha , Chahoud Jad , Spiess Philippe , Jim Heather , Johnstone Peter 
Published: November 2021

Abstract
Objective: Patient reports of their symptom burden (i.e., patient-reported outcomes or PROs) have been shown to direct clinicians’ ability to personalize care and improve outcomes. A disciplined assessment of PRO in the population of patients with penile cancer (PeCa) has not previously been undertaken. Our center has both a significant cadre of patients with PeCa and a significant experience with a well-established PRO: the Edmonton Symptom Assessment Scale (ESAS).Methods: After IRB approval, we screened ESAS surveys of 14,781 patients completed between 2/2017 and 2/2021. Of these, those with PeCa were divided into three cohorts: (A) Those after any partial penectomy procedure without lymph node dissection (LND); (B) Those after partial penectomy procedure with LND; and (C) Those after total penectomy and LND. Patients with recurrent disease were analyzed separately. ESAS scores were collated and compared both by individual symptom and cumulatively.Results: 22 PeCa patients completed 122 ESAS surveys in this time and are included in this analysis: a median of 4 ESAS surveys (mean=5, range=1-19) were completed by each patient. The symptom with the highest median ESAS score was Tiredness (3.00). Patients with recurrent disease had the highest cumulative symptom score (median score = 30). Patients after total penectomy with LND had a higher cumulative symptom score (14.4) than those with partial penectomy and LND (7.9).Conclusions: PROs provide an insight into the morbidity of therapies for PeCa, and the most symptoms are reported by patients with recurrent disease.
Investigation of Anxiety Sensitivity Levels of Cancer Patients In Terms of Covid 19 Vaccine: A Cross-Sectional Study
Authors: İŞCAN GÖKÇE , ÇETİN BÜLENT , KILIÇ FARUK , KALAYCI HAKAN , KALAYCI AYŞEGÜL 
Published: November 2021

Abstract
Introduction:

The goal of our research was to look into the perspectives of cancer patients who had not yet been vaccinated, aged from 21 to 88 years old and had applied to Süleyman Demirel University's oncology outpatient clinic in May and June, as well as their anxieties and concerns about vaccination.
Methods

The goal of this descriptive cross-sectional study was to investigate cancer patients’ perceptions of Covid vaccination. We applied 3 questionnaires, one of them prepared by us, the other two questionnaires were The State-Trait Anxiety Inventory (STAI) form and Anxiety Sensitivity index to a total of 497 participants. Chi-Square, Spearmen correlation test, multivariable multinomial logistic regression tests were used when comparing.
Results

Our participants were between the ages of 21 and 88, with a mean age of 61,38 (SD = 11,68). 48,6% (n=251) of all participants were female. We discovered that 79.1% (n=408) of respondents were not afraid of getting the COVID-19 vaccine. 27,7 % (n=143) of this population's respondents were concerned about the COVID-19 vaccine's negative effects and 24,2% (n=125) were afraid of its side effects with their treatments. 91,1% (n=470) of the patients did not know which vaccine they would have and the type of the vaccine. Due to the high level of anxiety in women in general, it was thought that anxiety scores were higher in patients with breast and ovarian cancer, which are important cancers in women during the pandemic period, while anxiety scores were lower in patients with prostate cancer since it was seen in men. Special patient groups should not be neglected during this vaccine season, and their concerns should be addressed. When a new vaccine is found, it can have long-term effects, which should not be ignored.
Comorbidities and COVID-19 Status Influence the Survival Rate of Geriatric Patients in Intensive Care Units: a Prospective Cohort Study From the Indonesian Society of Anaesthesiology and Intensive Therapy
Authors: Rehatta Nancy Margarita , Chandra Susilo , Sari Djayanti , Lestari Mayang Indah , Senapathi Tjokorda Gde Agung , Nurdin Haizah , Wirabuana Belindo , Pramodana Bintang , Pradhana Adinda Putra , Isngadi Isngadi , Anggraeni Novita , Sikumbang Kenanga Marwan , Halimi Radian Ahmad , Jasa Zafrullah Khany , Nasution Akhyar Hamonangan , Mochamat Mochamat , Purwoko Purwoko 
Published: November 2021

Abstract
Background: With the more advanced science in the field of medicine and disease management, the population of geriatric intensive care patients is increasing. The COVID-19 pandemic has impacted healthcare management around the globe, especially on critically-ill elderly patients. We aim to analyse the relationship between underlying illnesses, including COVID-19, and the survival rate of elderly patients who are treated in the intensive care setting.Methods: We conducted a prospective cohort study at 14 teaching hospitals for Anaesthesiology and Intensive Therapy Education in Indonesia. We selected all subjects with 60 years of age or older in the period between February to May 2021. Variables recorded included subject characteristics, comorbidities, and COVID-19 status. Subjects were followed for 30-day mortality as an outcome. We analysed the data using Kaplan-Meier survival analysis.Results: We recruited 982 elderly patients, and 728 subjects were in the final analysis (60.7% male; 68.0 ± 6.6 years old). The 30-day mortality was 38.6%. The top five comorbidities are hypertension (21.1%), diabetes (16.2%), moderate or severe renal disease (10.6%), congestive heart failure (9.2%), and cerebrovascular disease (9.1%). Subjects with Charlson's Comorbidity Index Score >5 experienced 66% death. Subjects with COVID-19 who died were 57.4%. Subjects with comorbidities and COVID-19 had lower survival rates than subjects without those conditions (p < 0.005).Conclusion: Approximately one in four elderly intensive care patients die, and the number is increasing with comorbidities and COVID-19 status.
Second stage African Trypanosomiasis presented as Non Convulsive Status Epilepticus
Authors: Ibrahim Etedal Ahmed A. , Elmahal Mohammed Gasm Elseed M , Ahmed Khabab Abbasher Hussien Mohamed , Omer Mohammed Eltahier Abdalla 
Published: November 2021

Abstract
Human African Trypanosomiasis also known as sleeping sickness is a common disease in South Sudan. There are two recognized sstage, The early hemolymphatic stage and The late encephalitic stage when the CNS is involved specially with Gambians infection, broad neurologic spectrum has been reported such as psychiatric, motor, sensory.
Three Dimensional Potential Energy Surface For The F3
Authors: Cao Jing , Hu Chunmei , Yu Hongmei , Bai Yuxuan , Li Yanchun , Wang Dequan , Huang Xuri 
Published: November 2021

Abstract
In order to study the F3 system, an accurate global adiabatic potential energy surface is reduced in the present work. The high level ab initio (MCSCF/MRCI level) methods with big basis set aVQZ are used to calculate 27690 potential energy points in MOLPRO quantum chemistry package using Jacobi coordinate. Meanwhile, B-spline fit method is used to reduce the global potential energy surface in this present work. The shallow well complexes are found in the present work when the angles θ = 30°, 60°, and 90°. Analysing the global potential energy surfaces one can get the conclusion that reactants should overcome at least 0.894 eV energy to cross transition state and reach products.
The Pozzolanic Activity of the Sediment Treated by the Flash Calcination Method
Authors: CHU DUC CHINH , AMAR Mouhamadou , KLEIB Joelle , BENZERZOUR Mahfoud , BETRANCOURT Damien , ABRIAK Nor-Edine , NADAH Jaouad 
Published: November 2021

Abstract
The dredged sediment has been positioned for years as alternative materials in the construction field. However, it is often necessary to apply a treatment to improve their reactivity and performance. This article aims to study the pozzolanic reactivity of fluvial sediment treated by flash calcination method at different temperatures 650 °C, 750 °C, and 800 °C. The physico-chemical, mineralogical, and environmental characteristics were studied for treated (flash-calcined sediment) and raw sediment. The pozzolanic reactivity of the flash-calcined sediments was estimated with Frattini’s test, isothermal calorimetry test, lime consumption analysis and compressive strength then compared to metakaolin which is considered as the reference. The results of the compressive strength of mortars show the detrimental effect of raw sediment on the development of resistance. Contrary to the raw sediment, the treatment of the sediments by flash calcination activates the pozzolanic reactivity of the clay phases and considerably improves the contribution of the sediments to the development of resistance and the porous structure. Moreover, the sediment calcined at 750 °C gives better properties than those obtained at 650 °C and 800 °C. The result demonstrates the feasibility of using calcined sediments as a pozzolanic mineral addition in a cementitious material.