bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of the putative cannabinoid receptor GPR55 is increased in endometrial carcinoma
Authors: Ayakannu Thangesweran , Taylor Anthony H. , Konje Justin C. 
Published: July 2021

AbstractAlthough the expression of the putative cannabinoid receptor GPR55 has been shown to be involved in the growth of various tumours and is increased in a number of cancers, its expression has not been examined in patients with endometrial cancer (EC). Quantitative RT-PCR (for mRNA levels) and immunohistochemistry (for protein levels) were used to measure GPR55 expression in patients with Type 1 and Type 2 EC and correlated against cannabinoid receptor (CB1 and CB2) protein levels using non-cancerous endometrium as the control tissue. The data indicated that GPR55 transcript and GPR55 protein levels were significantly (p < 0.002 and p < 0.0001, respectively) higher in EC tissues than in control tissues. The levels of immunoreactive GPR55 protein were correlated with GPR55 transcript levels, but not with the expression of CB1 receptor protein, and were inversely correlated with CB2 protein expression, which was significantly decreased. It can be concluded that GPR55 expression is elevated in women with EC, and thus could provide a potential novel biomarker and therapeutic target for this disease.
Preference between medical outcomes and travel times: an analysis of liver transplantation
Authors: Burkamp Jasper Richard , Bühn Stefanie , Schnitzbauer Andreas , Pieper Dawid 
Published: July 2021

AbstractBackgroundThere is evidence of a volume outcome relationship for liver transplantation. In Germany, there is a minimum volume threshold of 20 transplantations per year for each center. Thresholds potentially lead to centralization of the healthcare supply, generating longer travel times.ObjectiveThis study assessed whether patients are willing to travel longer times to transplantation centers for better outcomes (lower hospital mortality and higher 3-year survival) and identified patient characteristics influencing their choices.MethodsParticipants were recruited in hospitals and via random samples at registration offices. Discrete choice experiments were used to identify trade-offs in their choices between local and regional centers. Descriptive statistics and logistic regression models were used to measure patients’ preferences and quantify potentially influencing characteristics.ResultsOverall, 82.22% (in-hospital mortality) and 84.44% (3-year survival) of the participants opted to accept a longer travel time in order to receive a liver transplantation with better outcomes.ConclusionMost participants were willing to trade shorter travel times for lower mortality risks and higher 3-year survival in cases of liver transplantation.
GOALIATH: a theory of goal-directed behavior
Authors: Hommel Bernhard 
Published: July 2021

AbstractCommonsense and theorizing about action control agree in assuming that human behavior is (mainly) driven by goals, but no mechanistic theory of what goals are, where they come from, and how they impact action selection is available. Here I develop such a theory that is based on the assumption that GOALs guide Intentional Actions THrough criteria (GOALIATH). The theory is intended to be minimalist and parsimonious with respect to its assumptions, as transparent and mechanistic as possible, and it is based on representational assumptions provided by the Theory of Event Coding (TEC). It holds that goal-directed behavior is guided by selection criteria that activate and create competition between event files that contain action-effect codes matching one or more of the criteria—a competition that eventually settles into a solution favoring the best-matching event file. The criteria are associated with various sources, including biological drives, acquired needs (e.g., of achievement, power, or affiliation), and short-term, sometimes arbitrary, instructed aims. Action selection is, thus, a compromise that tries to satisfy various criteria related to different driving forces, which are also likely to vary in strength over time. Hence, what looks like goal-directed action emerges from, and represents an attempt to satisfy multiple constraints with different origins, purposes, operational characteristics, and timescales—which among other things does not guarantee a high degree of coherence or rationality of the eventual outcome. GOALIATH calls for a radical break with conventional theorizing about the control of goal-directed behavior, as it among other things questions existing cognitive-control theories and dual-route models of action control.
Using company-specific headlines and convolutional neural networks to predict stock fluctuations
Authors: Readshaw Jonathan , Giani Stefano 
Published: July 2021

AbstractThis work presents a convolutional neural network for the prediction of next-day stock fluctuations using company-specific news headlines. Experiments to evaluate model performance using various configurations of word embeddings and convolutional filter widths are reported. The total number of convolutional filters used is far fewer than is common, reducing the dimensionality of the task without loss of accuracy. Furthermore, multiple hidden layers with decreasing dimensionality are employed. A classification accuracy of 61.7% is achieved using pre-learned embeddings, that are fine-tuned during training to represent the specific context of this task. Multiple filter widths are also implemented to detect different length phrases that are key for classification. Trading simulations are conducted using the presented classification results. Initial investments are more than tripled over an 838-day testing period using the optimal classification configuration and a simple trading strategy. Two novel methods are presented to reduce the risk of the trading simulations. Adjustment of the sigmoid class threshold and re-labelling headlines using multiple classes form the basis of these methods. A combination of these approaches is found to be more than double the Average Trade Profit achieved during baseline simulations.
Laser Spectroscopy Measurements of Metastable Pionic Helium Atoms at Paul Scherrer Institute
Authors: Hori M. , Aghai-Khozani H. , Sótér A. , Dax A. , Barna D. 
Published: July 2021

AbstractWe review recent experiments carried out by the PiHe collaboration of the Paul Scherrer Institute (PSI) that observed an infrared transition of three-body pionic helium atoms by laser spectroscopy. These measurements may lead to a precise determination of the charged pion mass, and complement experiments of antiprotonic helium atoms carried out at the new ELENA facility of CERN.
Effects of habitat conditions on the boldness and sociability of wild-caught fish (Zacco platypus) along a river
Authors: Tang Zhonghua , Fu Shi-Jian 
Published: July 2021

AbstractWild fish show consistent behavioral differences, e.g., personalities among populations, whereas the possible relationships between personality and environmental conditions have seldom been systemically examined. We aimed to test whether the personality of wild-caught fish was affected by the biotic (food resources and predation) and abiotic (temperature, dissolved oxygen level, and flow velocity) conditions of natural habitats. Six populations of pale chub (Zacco platypus) were sampled along a river longer than 1000 km, and environmental conditions and personality characteristics, such as boldness, activity, and sociability, were measured. Personality variables could be reduced to two factors by principal component analysis, boldness, and sociability factors, with the former factor having more variation among and within populations. Individuals from populations with higher food availability (plankton density) and flow velocity generally showed higher boldness factor scores, possibly due to the better energy status of higher food abundance or the low water transparency and hence decreased predation risk and fast-flow lifestyle of populations with higher water velocity populations. All populations showed high sociability as group-living species, which was positively correlated with only the phytoplankton biomass, possibly due to decreased intraspecific competition in habitats with abundant food resources. The correlations among personality variables were population-dependent, as individuals who moved more had a shorter distance to the stimulus shoal (i.e., increased shoaling tendency) within high-predation populations, whereas individuals who moved more spent less time in shoals within low-predation populations. The results suggest that alterations in habitat conditions can result in divergent natural selection that favors a particular personality; thus, human-induced alterations in habitat conditions may shape the personality of individual fish.
Early Atherosclerotic Changes in Coronary Arteries are Associated with Endothelium Shear Stress Contraction/Expansion Variability
Authors: Mazzi Valentina , De Nisco Giuseppe , Hoogendoorn Ayla , Calò Karol , Chiastra Claudio , Gallo Diego , Steinman David A. , Wentzel Jolanda J. , Morbiducci Umberto 
Published: July 2021

AbstractAlthough unphysiological wall shear stress (WSS) has become the consensus hemodynamic mechanism for coronary atherosclerosis, the complex biomechanical stimulus affecting atherosclerosis evolution is still undetermined. This has motivated the interest on the contraction/expansion action exerted by WSS on the endothelium, obtained through the WSS topological skeleton analysis. This study tests the ability of this WSS feature, alone or combined with WSS magnitude, to predict coronary wall thickness (WT) longitudinal changes. Nine coronary arteries of hypercholesterolemic minipigs underwent imaging with local WT measurement at three time points: baseline (T1), after 5.6 ± 0.9 (T2), and 7.6 ± 2.5 (T3) months. Individualized computational hemodynamic simulations were performed at T1 and T2. The variability of the WSS contraction/expansion action along the cardiac cycle was quantified using the WSS topological shear variation index (TSVI). Alone or combined, high TSVI and low WSS significantly co-localized with high WT at the same time points and were significant predictors of thickening at later time points. TSVI and WSS magnitude values in a physiological range appeared to play an atheroprotective role. Both the variability of the WSS contraction/expansion action and WSS magnitude, accounting for different hemodynamic effects on the endothelium, (1) are linked to WT changes and (2) concur to identify WSS features leading to coronary atherosclerosis.
Application of supported lanthanum catalysts in the hydrogenation of nitriles
Authors: Juhász Kinga , Lévay Krisztina , Hegedűs László , Balogh-Weiser Diána , Pirault-Roy Laurence , Hell Zoltán 
Published: July 2021

AbstractNickel and lanthanum on MgO or MgO–Al2O3catalysts were prepared and characterized. The applicability of the catalysts was studied in the liquid-phase hydrogenation of benzonitrile. A La/MgO catalyst showed surprisingly high activity and selectivity. The scope of the reaction was extended to other nitriles (benzyl cyanide, cinnamonitrile, adiponitrile) over this La/MgO catalyst.
Do prior knowledge, model-observer similarity and social comparison influence the effectiveness of eye movement modeling examples for supporting multimedia learning?
Authors: Krebs Marie-Christin , Schüler Anne , Scheiter Katharina 
Published: July 2021

AbstractWe investigated in an experiment with 180 university students the joint role of prior knowledge, alleged model competence, and social comparison orientation regarding the effectiveness of Eye Movement Modeling Examples (EMME) for supporting multimedia learning. EMME consisted of short videos with gaze replays of an instructed model demonstrating effective multimedia processing strategies. Participants were either instructed that the model in the EMME-videos was a successful learner (competent model) or another participant (peer model). Participants in a control condition received no EMME. Furthermore, we activated domain-relevant prior knowledge in half of the participants before watching the EMME. Against our expectations, we found no influence of either prior knowledge activation or model-observer similarity. As expected, our results indicated that EMME fostered multimedia learning. This was also supported by findings from small-scale meta-analyses that were conducted with the focus on the effect of EMME for multimedia learning and potential moderators of the effect. Moreover, results showed first evidence that social comparison orientation interacts with (alleged) model competence regarding the effectiveness of EMME. Further research is needed to follow up on the influence of individual factors as well as social cues on the effectiveness of EMME.
Burnout in Surgical Trainees: a Narrative Review of Trends, Contributors, Consequences and Possible Interventions
Authors: Johnson Judith , Al-Ghunaim Tmam Abdulaziz , Biyani Chandra Shekhar , Montgomery Anthony , Morley Roland , O’Connor Daryl B. 
Published: July 2021

AbstractSurgical disciplines are popular and training places are competitive to obtain, but trainees report higher levels of burnout than either their non-surgical peers or attending or consultant surgeons. In this review, we critically summarise evidence on trends and changes in burnout over the past decade, contributors to surgical trainee burnout, the personal and professional consequences of burnout and consider the evidence for interventions. There is no evidence for a linear increase in burnout levels in surgeons over the past decade but the impact of the COVID-19 pandemic has yet to be established and is likely to be significant. Working long hours and experiencing stressful interpersonal interactions at work are associated with higher burnout in trainees but feeling more supported by training programmes and receiving workplace supervision are associated with reduced burnout. Burnout is associated with poorer overall mental and physical well-being in surgical trainees and has also been linked with the delivery of less safe patient care in this group. Useful interventions could include mentorship and improving work conditions, but there is a need for more and higher quality studies.
Incidence of Acute Kidney Injury Is Lower in High-Risk Patients Undergoing Percutaneous Coronary Intervention Supported with Impella Compared to ECMO
Authors: Schweitzer Julian , Horn Patrick , Voss Fabian , Kivel Milena , Wolff Georg , Jung Christian , Zeus Tobias , Kelm Malte , Westenfeld Ralf 
Published: July 2021

AbstractAcute kidney injury (AKI) is a common complication post-PCI. Here, in a single-center observational registry, we compared the frequency of AKI in patients at elevated risk for AKI (based on Mehran risk stratification scoring) who underwent VA-ECMO- or Impella-supported high-risk PCI. A total of 28 patients scheduled for elective high-risk PCI with mechanical circulatory support were studied prospectively. All patients were turned down for surgery due to exceedingly high risk. Allocation to VA-ECMO (n=11) or Impella (n=17) was performed according to site-specific restrictions on the daily availability of the VA-ECMO platform as a prospective enrollment and performed prior to initiation of PCI. We analyzed AKI incidence as our primary endpoint, as well as PCI success, duration, and peripheral complications. All patients were successfully revascularized and had MCS weaned at the end of the procedure. Baseline GFR and procedural contrast media were similar. Despite similar risks for AKI as calculated by the Mehran score (35 ± 18.9 vs. 31 ± 16.6 %; p=0.55), patients supported by Impella during PCI demonstrated a reduced incidence of AKI (55 vs. 12 %; p=0.03). MCS-assisted high-risk PCI with VA-ECMO or Impella is feasible. However, Impella is associated with a shorter procedure time and a lower incidence of AKI.
A New Era Is Beginning in Central and Eastern Europe: Information and Communication Technology Services Exceed Manufacturing in the Global Production Chain
Authors: Cieślik Ewa 
Published: July 2021

AbstractThe article compares changes in tendencies of value-added flows and the places held by the Central and Eastern European economies (11 countries: Visegrad countries, Baltic States, Slovenia, Bulgaria, Croatia, and Romania; CEE) in global value chains (GVCs) in manufacturing, services, and their subgroup—information and telecommunication (ICT) services, by relying on the trade in value-added data retrieved from the OECD’s Inter-Country Input–Output Database, available over the period 2005–2015. The objective of this study is to understand the role of these economies in international production linkages applying a value-added methodology. Therefore, the study discusses the role of CEE economies in global economy in terms of forms of participation of services, especially ICT services, in GVCs, including the process of “servicification” of manufacturing. This study led to the verification of two hypotheses: (1) the position of manufacturing in GVCs has been steadily weakening and (2) services, especially ICT services, can have a positive effect on participation of CEE economies in GVCs. The first hypothesis was confirmed by most of analysed countries. The other research question turned out not to be true for all CEE countries, but most of them proved this hypothesis.
Structure-sensitive testimonial norms
Authors: Höltgen Benedikt T. A. 
Published: July 2021

AbstractAlthough there has been a lot of investigation into the influence of the network structure of scientific communities on the one hand and into testimonial norms (TNs) on the other, a discussion of TNs that take the network structure into account has been lacking. In this paper, I introduce two TNs which are sensitive to the local network structure. According to these norms, scientists should give less weight to the results of well-connected colleagues, as compared to less connected ones. I employ an Agent Based Model to test the reliability of the two novel TNs against different versions of conventional, structure-insensitive TNs in networks of varying size and structure. The results of the simulations show that the novel TNs are more reliable. This suggests that it would be beneficial for scientific communities if their members followed such norms. For individual scientists, I show that there are both reasons for and reasons against adopting them.
Pleural Manometry—Basics for Clinical Practice
Authors: Faber Katarzyna , Krenke Rafal 
Published: July 2021

Abstract
Purpose of Review
The aim of this paper is to present basic data on pleural manometry and to outline the advances in its use as both a research tool enabling a better understanding of pleural pathophysiology and as a clinical tool useful in management strategy planning in patients with pleural diseases. To discuss updates and current trends in the development of pleural manometry, a search of the literature on pleural manometry published in recent years was performed.

Recent Findings
The technique of pleural manometry has significantly evolved over the last 40 years from simple water manometers to electronic or digital devices which enable the measurement and recording of instantaneous pleural pressure. Although to date it is mainly used as a research tool, pleural manometry has the potential to be applied in clinical practice. Recent studies demonstrated that monitoring of pleural pressure changes during therapeutic thoracentesis does not seem to be helpful in predicting re-expansion pulmonary edema and procedure-related chest discomfort. On the other hand, measurement of pleural elastance plays an important role in the diagnosis of unexpandable lung in patients with malignant pleural effusion facilitating determination of the optimal management strategy. Additionally, it allows for study of newly discovered phenomena, including pleural pressure pulse assessment and the impact of continuous positive airway pressure and cough on pleural pressure.

Summary
Pleural manometry is an established technique of pleural pressure measurement. Despite recent advances, its role in clinical practice remains undetermined.
The Rise of ‘Group Solution’ in Insolvency Law and Bank Resolution
Authors: Kokorin Ilya 
Published: July 2021

AbstractThis article traces the emergence of the concept of ‘group solution’ and its manifestations in insolvency law and bank resolution as an alternative to the rigid entity-by-entity approach. The rise of this concept can be linked to the recognition of the specificity of problems related to the insolvency of multinational enterprise groups, arising from group operational and financial interconnectedness. This has not happened at once, but has resulted from the evolution of views and ideas, evident in hard and soft law instruments of the 2000s and the 2010s. In light of this important development the article explores the concept of a group solution, its rationale, scope of application and limitations. It concludes that despite the gradual acceptance of the group phenomenon, a group solution has not been formed as a coherent and well-defined legal principle. Instead, it represents a variety of approaches, tools and practices, which pursue different policy objectives underpinned by different societal values. Among them are asset value maximization, business rescue, the protection of financial stability and the preservation of banks’ critical functions. With all its flexibility, a group solution has one pervasive limitation—it cannot trump the interests of individual group members and their creditors. At the same time, in order to realize the full potential of a group solution, it is necessary to embrace the group-sensitive and forward-looking interpretation of creditors’ interest, facilitating commercially sensible and practical group solutions.
Parameters Affecting the Precipitation of Al Phases from Aluminate Solutions of the Pedersen Process: The Effect of Carbonate Content
Authors: Marinos Danai , Vafeias Michail , Sparis Dimitris , Kotsanis Dimitris , Balomenos Efthymios , Panias Dimitris 
Published: July 2021

AbstractLeaching experiments were performed in calcium aluminate slag with a high-sodium carbonate adaptation of the Pedersen process. A theoretical thermodynamic study of the pregnant leaching solution was conducted to specify the thermodynamically favored species that exist within. Using the HSC 9.0 software, a carbonation process simulation (neutralization of the aluminate solution with CO2 gas) was simulated. Laboratory carbonation experiments were conducted to verify the theoretical predictions. According to the thermodynamic study, at temperatures below 50 °C gibbsite precipitates in the first stages of carbonation and then is transformed to dawsonite. Temperatures over 65 °C favor the direct precipitation of dawsonite. The same route (thermodynamic analysis, carbonation simulation, and experimental verification) was followed by a synthetic solution containing lower amount of sodium carbonate to prove that dawsonite precipitation occurred as a result of the high free carbonate content, to investigate the effect of temperature and to precipitate alumina hydrate phases.
Graphical Abstract