bluuebunny/crossref_metadata_2025_split huggingface dataset:
Síndrome de salida torácica neurogénico asociado a costilla cervical. Reporte de un caso y revisión bibliográfica
Authors: Delgado Servín de la Mora Itzel , Martín Gutiérrez Patricia , Muñoz Montiel Yuv Gabriela , Reyes Pavón Rodrigo , Torres García Cristal , Esparza Ramos Susana Berenice 
Published: March 2021

El síndrome de salida torácica (SST) está determinado por la compresión de alguno de los elementos neurovasculares contenidos en la salida torácica (los vasos subclavios y el plexo braquial). Puede clasificarse como SST neurogénico, arterial, venoso, traumático, y cuestionable. Una de las etiologías más descritas es la presencia de costillas supernumerarias cervicales, encontradas en el 0.2 al 1.0 % de la población general, la mayoría asintomáticas, aunque pueden cursar con cualquiera de los SST antes mencionados. En el caso del SST- neurogénico, las manifestaciones clínicas las representa la Neuralgia Cervicobraquial: consiste en dolor en cuello y hombro, así como dolor, parestesias, disestesias y debilidad en el miembro afectado. El tratamiento conservador, basado en la movilización activa, estiramientos y fortalecimiento de músculos escapulotorácicos, debe considerarse la primera opción en todos los pacientes. El tratamiento quirúrgico se reserva para las manifestaciones tromboembólicas, neurológicas refractarias o con deterioro progresivo, así como de insuficiencia arterial; se realiza mediante la resección de la costilla supernumeraria por vía supraclavicular o transaxilar.Se presenta un caso de una paciente de 21 años que acude a la consulta por debilidad en miembro torácico derecho, parestesias en territorio del nervio cubital, sensación de piel fría y dolor en zona del trapecio y del codo derecho, con una evolución de tres meses. La maniobra de Adson-Wright fue positiva en miembro derecho. Se confirmó el diagnóstico por hallazgo radiológico de costilla cervical bilateral que se origina de C7 y mega-apófisis transversa de C6, por lo que se instaura tratamiento conservador. LUXMÉDICA, AÑO 13, NÚMERO 38, MAYO-AGOSTO 2018, PP 43-48.
Combination of Storytelling and Music Therapy to Reduce Stress in Children with HIV/AIDS and Discrimination in Surabaya
Authors: Darmawan Taufan Citra 
Published: March 2021

Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) in Indonesia are deadly infectious diseases. This disease will always be a problem at the national and global levels. The impact that often occurs, especially in children with HIV/AIDS, is psychological changes, namely stress. Efforts to overcome its disturbance are storytelling and music therapy. This research aims to apply storytelling and music therapy to reduce stress in children with HIV/AIDS.
This research method was a quasi-experiment with a research design involving 1 group (one group pre-post test), containing 30 respondents aged 6-10 years with HIV/AIDS by purposive sampling. The independent variable was storytelling and music therapy, while the dependent variable was stress levels. The instrument used Hamilton Anxiety Questionaire (HAM-A).
The results of the study showed that 26 samples (86.7%) experienced decreased stress levels. Analysis of Wilcoxon sign rank test obtained α=0.009, which means there was a difference before and after therapy.
The combination of music therapy and storytelling can be a better alternative in reducing stress in children – by considering age, environment, and children's emotions to have an optimal effect.
Josep Maria Pujol, el rei en Jaume i el "Llibre dels fets"
Authors: Renedo Puig Xavier 
Published: March 2021

<p>Aquest article és una versió un xic ampliada d’una conferència que vaig llegir el 19-xii-2012 a la Universitat Rovira i Virgili en un acte d’homenatge a Josep Maria Pujol organitzat pels seus companys del Departament de Filologia Catalana.</p>
Primary Hyperparathyroidism with Multiple Fractures and Brown Tumors in a 14-year-old Girl: Case Report & Review of Literature
Authors: Khan Nasim , Nahar Nazmun , Ara Rawshan , Dowel Fahima Akter , Rima Shakila Zaman , Chakraborty Ratan Kumar , Nadiruzzaman - , Mahmood Saiyeeda , Hossain Gazi Abul 
Published: March 2021

Primary hyperparathyroidism (PHPT) presenting as pathological fractures with brown tumors is very rare in children. The rarity and variable presentation of PHPT can make its diagnosis a challenge – especially in the developing countries where malnutrition may mask hypercalcemia. We report a case of a 14–year-old girl who presented with muscle pain, multiple fractures and bone pain. Laboratory tests revealed normocalcemia with vitamin D insufficiency. Subsequent biochemical, radiographic and scintigraphic findings were consistent with primary hyperparathyroidism due to a parathyroid adenoma. Tumor resection was done in a local hospital and histopathology confirmed parathyroid adenoma. Following parathyroidectomy, fractures were treated conservatively with supplementation of calcium and vitamin D. We found her quite capable of self-care and walking in good health at 1 year follow up. Though rare, PHPT-causing brown tumors related skeletal fractures is an important differential diagnosis in the evaluation of patients presenting with multiple foci of radiotracer uptake in bone scintigraphy.
Bangladesh J. Nuclear Med. 22(2): 130-136, Jul 2019
Passive Smoking and Pediatric Dental Caries
Authors: Munira Sirajam , Islam Md Ziaul , Sekander Md Towfiq , Alam Badrul 
Published: March 2021

Background: Dental caries is a chronic dental disorder of children and it can result in substantial morbidity due to pain, dysfunction, poor appearance, and problems of speech development. The study was conducted to assess the association between passive smoking and pediatric dental caries.
Methods: The cross-sectional study was conducted among 92 school children aged 5-10 years. Data on exposure to passive smoking at both indoor and outdoor were obtained through face to face interview of the parents with the help of semi-structured questionnaire and checklist. Dental caries was diagnosed by clinical examination and passive smoking exposure was assessed by estimated urinary cotinine level.
Results: The study revealed that 58.70% children were male and 41% were female respectively. The mean age of the children was 7.20 years. It was found that 59.8% father of the studied children were smoker where 68.5% children reported that some of their family members were indoor smokers. Of all the children, 62% had dental caries and 85.5% of the children had dental caries who were exposed to passive smoking and had significant association between exposure to passive smoking and dental caries (p<0.001). Dental caries was common among children aged 5-6years who were exposed to passive smok ing. The mean urinary cotinine level was 27.81 ng/ml and maximum children (65.2%) had urinary cotinine level more than 10ng/ml who was exposed to passive smoking. The study found significant positive correlation between urinary cotinine concentrations and the duration of exposure to passive smoking (i=0.692, p<0.001).
Conclusion: This study suggests reduction of exposure to passive smoking may be an effective measure for prevention of pediatric dental caries.
JOPSOM 2020; 39(1): 1-13
Caracterização epidemiológica da sífilis congênita em Teresina-Piauí no período de 2013 a 2017
Authors: Araújo Juliana de Morais , Silva Aline Correia Matos e , Santana Rosane da Silva , Silva Francisco Alex do Nascimento da , Santos Eliete Carneiro dos , Pereira Ana Cristina Ferreira , Brandim Adriana de Sousa , Morais Erica Jorgiana dos Santos de , Lima Angélica Linhares Silva , Santos Maria Oneide dos , Carvalho Fabíola Pires Lima de , Sousa Juliene Pereira de , Rodrigues Patrícia Cristiane Feitosa 
Published: March 2021

A sífilis congênita é uma infecção de múltiplos sistemas causada pelo Treponema pallidum, transmitida ao feto pela placenta, em qualquer período gestacional ou durante o parto. No Brasil, anualmente, observa-se o aumento do número de notificações associadas aos casos de sífilis durante a gestação, 80% com contaminação fetal. Objetivou-se analisar as características epidemiológicas da Sífilis Congênita em Teresina-PI nos anos de 2013 a 2017. Pesquisa descritiva com dados secundários coletados no DATASUS, por meio do Sistema de Informação de Agravos de Notificação (SINAN). Foram incluídas no estudo as variáveis dos RNs/Crianças, da mãe e do parceiro e excluídas somente as variáveis maternas que estavam em análise e não disponibilizadas pelo Sistema. Para a organização dos dados, foi utilizado Tabwin32, tabulador de dados desenvolvido pelo DATASUS/MS. Utilizou-se a estatística descritiva com frequências absolutas, relativas para apresentação dos resultados. Foram encontrados 1.180 casos de SC, sendo que no ano de 2013 apresentou 110 (9,32%) casos e 2015, 336 (25,82%). Quanto às características do RNs/crianças, 591 (50,08%) eram do sexo masculino, 1.133 (96,01%) tinham faixa etária de 0 a seis dias, 755 (63,98%) raça parda, 1.003 (85%) residentes na zona urbana, e 1.052 (89,15%) com diagnóstico de SC recente. Verificou-se que 435 (36,86%) mães tinham baixa escolaridade, 986 (83,55%) realizaram o pré-natal e 800 (67,79%) parceiros não realizaram o tratamento. Os números de casos elevados demonstram fragilidade na assistência durante o pré-natal com baixa efetividade das ações de promoção e prevenção, bem como tratamento e fatores determinantes no controle da sífilis congênita.
Proteinase-Mediated Macrophage Signaling in Psoriatic Arthritis
Authors: Abji Fatima , Rasti Mozhgan , Gómez-Aristizábal Alejandro , Muytjens Carla , Saifeddine Mahmoud , Mihara Koichiro , Motahhari Majid , Gandhi Rajiv , Viswanathan Sowmya , Hollenberg Morley D. , Oikonomopoulou Katerina , Chandran Vinod 
Published: March 2021

ObjectiveMultiple proteinases are present in the synovial fluid (SF) of an arthritic joint. We aimed to identify inflammatory cell populations present in psoriatic arthritis (PsA) SF compared to osteoarthritis (OA) and rheumatoid arthritis (RA), identify their proteinase-activated receptor 2 (PAR2) signaling function and characterize potentially active SF serine proteinases that may be PAR2 activators.MethodsFlow cytometry was used to characterize SF cells from PsA, RA, OA patients; PsA SF cells were further characterized by single cell 3’-RNA-sequencing. Active serine proteinases were identified through cleavage of fluorogenic trypsin- and chymotrypsin-like substrates, activity-based probe analysis and proteomics. Fluo-4 AM was used to monitor intracellular calcium cell signaling. Cytokine expression was evaluated using a multiplex Luminex panel.ResultsPsA SF cells were dominated by monocytes/macrophages, which consisted of three populations representing classical, non-classical and intermediate cells. The classical monocytes/macrophages were reduced in PsA compared to OA/RA, whilst the intermediate population was increased. PAR2 was elevated in OA vs. PsA/RA SF monocytes/macrophages, particularly in the intermediate population. PAR2 expression and signaling in primary PsA monocytes/macrophages significantly impacted the production of monocyte chemoattractant protein-1 (MCP-1). Trypsin-like serine proteinase activity was elevated in PsA and RA SF compared to OA, while chymotrypsin-like activity was elevated in RA compared to PsA. Tryptase-6 was identified as an active serine proteinase in SF that could trigger calcium signaling partially via PAR2.ConclusionPAR2 and its activating proteinases, including tryptase-6, can be important mediators of inflammation in PsA. Components within this proteinase-receptor axis may represent novel therapeutic targets.
Stroke Preventability in Large Vessel Occlusion Treated With Mechanical Thrombectomy
Authors: Suzuki Shuichi , Wadi Lara , Moores Lisa , Yuki Ichiro , Kim Jeein , Xu Jordan , Paganini-Hill Annlia , Fisher Mark 
Published: March 2021

Objective: The preventability of strokes treated by mechanical thrombectomy is unknown. The purpose of this study was to analyze stroke preventability for patients treated with mechanical thrombectomy for large vessel occlusion.Methods: We conducted retrospective analyses of 300 patients (mean ± SE age 69 ± 0.9 years, range 18–97 years; 53% male) treated with mechanical thrombectomy for large vessel occlusion from January 2008 to March 2019. We collected data including demographics, NIH Stroke Scale (NIHSS) at onset, and (beginning in 2015) classified 90-day outcome by modified Rankin Scale (mRS). Patients were evaluated using a Stroke Preventability Score (SPS, 0 to 10 points) based on how well patients had been treated given their hypertension, hyperlipidemia, atrial fibrillation, and prior stroke history. We examined the relationship of SPS with NIHSS at stroke onset and with mRS outcome at 90 days.Results: SPS was calculated for 272 of the 300 patients, with mean ± SE of 2.1 ± 0.1 (range 0–8); 89 (33%) had no preventability (score 0), 120 (44%) had low preventability (score 1–3), and 63 (23%) had high preventability (score 4 or higher). SPS was significantly correlated with age (r = 0.32, p &lt; 0.0001), while NIHSS (n = 267) was significantly higher (p = 0.03) for patients with high stroke preventability vs. low/no preventability [18.8 ± 0.92 (n = 62) vs. 16.5 ± 0.51 (n = 205)]. Among 118 patients with mRS, outcome was significantly worse (p = 0.04) in patients with high stroke preventability vs. low/no preventability [4.7 ± 0.29 (n = 28) vs. 3.8 ± 0.21 (n = 90)]. The vast majority of patients with high stroke preventability had inadequately treated atrial fibrillation (85%, 53/62).Conclusions: Nearly one quarter of stroke patients undergoing mechanical thrombectomy had highly preventable strokes. While stroke preventability showed some relationship to stroke severity at onset and outcome after treatment, preventability had the strongest association with age. These findings emphasize the need for improved stroke prevention in the elderly.
MiR-21-3p Promotes Hepatocellular Carcinoma Progression via SMAD7/YAP1 Regulation
Authors: Hong Yinghui , Ye Mingliang , Wang Fan , Fang Jun , Wang Chun , Luo Jie , Liu Jialiang , Liu Jing , Liu Lan , Zhao Qiu , Chang Ying 
Published: March 2021

BackgroundHepatocellular carcinoma (HCC) remains a major global health burden due to its high prevalence and mortality. Emerging evidence reveals that microRNA (miRNA) plays a vital role in cancer pathogenesis and is widely involved in the regulation of signaling pathways via their targeting of downstream genes. MiR-21-3p, a liver-enriched miRNA, and SMAD7, the negative regulator of the TGF-β signaling pathway, likely exert a vital influence on HCC progression.AimsHere, we explore the role of the miR-21-3p-SMAD7/YAP1 axis on HCC pathogenesis.MethodsMiRNA microarray analysis was performed for miRNA screening. The dual-luciferase assay was adopted for target verification. Expression of miRNA and related genes were quantified via qRT-PCR, western blotting, and immunohistochemical staining. Flow cytometry and the transwell migration assay were used to detail cell apoptosis, invasion and metastases. Rat models were established to explore the role of the miR-21-3p-SMAD7/YAP1 axis in hepatocarcinogenesis. Bioinformatics analysis was conducted for exploring genes of clinical significance.ResultsMiR-21-3p levels were found to be significantly elevated in hepatocellular carcinoma and indicate poor overall survival. High miR-21-3p levels were associated with advanced tumor stages (P = 0.029), in particular T staging (P = 0.026). Low SMAD7/high YAP1 levels were confirmed in both HCC and rat models with advanced liver fibrosis and cirrhosis. Besides, SMAD7 was demonstrated to be the direct target of miR-21-3p. The effect of MiR-21-3p on tumor phenotypes and YAP1 upregulation could be partly reversed via the restoration of SMAD7 expression in HCC cell lines. Overexpression of YAP1 after miR-21-3p upregulation promoted expression of nuclear transcription effector connective tissue growth factor. Co-survival analysis indicated that lower miR-21-3p/higher SMAD7 (P = 0.0494) and lower miR-21-3p/lower YAP1 (P = 0.0379) group patients had better overall survival rates. Gene Set Variation Analysis revealed that gene sets related to miR-21-3p and SMAD7 were significantly associated with the TGF-β signaling pathway in HCC.ConclusionMiR-21-3p promotes migration and invasion of HCC cells and upregulation of YAP1 expression via direct inhibition of SMAD7, underscoring a major epigenetic mechanism in the pathogenesis of HCC.
Effect of Micelle-Incorporated Cisplatin With Sizes Ranging From 8 to 40 nm for the Therapy of Lewis Lung Carcinoma
Authors: Wang Zhicheng , Li Yumin , Zhang Tong , Li Hongxia , Yang Zhao , Wang Cheng 
Published: March 2021

Insufficient transport of therapeutic cargo into tumor bed is a bottleneck in cancer nanomedicine. Block copolymers are promising carriers with smaller particle size by ratio modification. Here, we constructed cisplatin nanoparticles with sizes ranging from 8 to 40 nm to study the permeability and therapy of Lewis lung carcinoma. We synthesized methoxypoly(ethylene glycol)2000-block poly(L-glutamic acid sodium salt)1979loading cisplatin through complexation reaction. The cisplatin nanomedicine has high drug loading and encapsulation efficiency.In vitrodata demonstrated that cisplatin nanoparticles had equivalent growth-inhibiting effects on Lewis lung carcinoma cells compared to free cisplatin.In vivoevidences showed cisplatin nanoparticles had superior antitumor effects on the Lewis lung carcinoma mouse model with no obvious side effects. All results indicated that optimizing the ratio of block copolymers to obtain smaller sized nanomedicine could act as a promising strategy for overcoming the inadequate accumulation in poorly vascularized tumors.
Protección de la niñez contra la violencia sexual: Educomunicación, prevención y transformación social
Authors: Dávila Navarro Edgar 
Published: March 2021

El presente estudio tiene como objetivo identificar procesos educomunicacionales para la prevención de la violencia sexual en niñas y niños en el marco del proyecto “Protección e Igualdad de Género”, impulsado por el organismo no gubernamental Plan International. Esta experiencia fue implementada de junio a diciembre de 2018 en los municipios de Achacachi y Jesús de Machaca (La Paz), Padcaya y San Lorenzo (Tarija), Buena Vista y El Torno (Santa Cruz) y, por último, en Tarabuco y Zudañez (Chuquisaca). La presente investigación presenta al campo de la educomunicación como una herramienta capaz de generar procesos de transformación social (Aparici, 2003) –en este caso– en beneficio y protección de niñas y niños.
El enfoque metodológico del estudio es cualitativo, se aplicaron entrevistas en profundidad y grupos focales a madres, padres, niñas y niños, con el fin de recoger información descriptiva que permita explicar el fenómeno. Los resultados muestran que tanto niñas como niños son capaces de identificar señales de violencia y denunciar cualquier acción que viole su derecho a la protección. El análisis que se expone a continuación contribuye al debate sobre el desarrollo de competencias educomunicativas, con el fin de construir un ambiente favorable para la autoprotección y protección de la niñez y, al mismo tiempo, verifica que las poblaciones estudiadas son capaces de prevenir y reducir hechos violentos a través de procesos educomunicativos.
Estimación de Biomasa Aérea y Carbono con Teledetección en Bosques Alto-Andinos de Boyacá, Colombia. Estudio de caso: Santuario de Fauna y Flora Iguaque
Authors: Perea-Ardila Mauricio Alejandro , Andrade-Castañeda Hernán J. , Segura-Madrigal Milena A. 
Published: March 2021

Las herramientas de teledetección son clave para el monitoreo de biomasa y carbono en bosques, importantes para mitigar el cambio climático. Se estimó la biomasa aérea y carbono a través de teledetección en bosques alto-andinos del Santuario de Fauna y Flora Iguaque (SFFI) de Boyacá, Colombia. Se establecieron 23 parcelas temporales de muestreo (PTM) de 250 m2 y se midieron los árboles con diámetro a la altura del pecho (dap) ≥ 10 cm. La biomasa aérea se estimó con una ecuación alométrica y se correlacionó con tres índices de vegetación (NDVI, SAVI y EVI) obtenidos de dos imágenes del satélite LANDSAT 8 OLI en época seca y lluviosa (2016). Se probraron modelos lineales para estimar la biomasa en función del índice de vegetación y se estimó el carbono. Los bosques del SFFI almacenaron 30 t C/ha en biomasa aérea, y el mejor modelo se basó en el NDVI de la época seca (R2aj = 0,79). Se confeccionaron mapas con la distrribución de biomasa y carbono. Los bosques del SSFI han removido de la atmósfera 164 Gg CO2, los cuales podrían volver a emitirse en caso de no conservarse. Las áreas con mayor biomasa y carbono estuvieron principalmente en el suroeste y norte del SFFI. Con este estudio se hace una primera aproximación del patrón de distribución de la biomasa aérea y carbono con resolución de 30 m. Se ratifica el uso de datos de sensores remotos como insumo primordial para el monitoreo de proyectos de carbono en ecosistemas forestales.
MANAJEMEN PENGEMBANGAN SDM DI PONDOK PESANTREN AS-SYAFAAH KEBONSARI JEMBER
Authors: Mu’is Abdul 
Published: March 2021

Tujuan dari penelitian ini adalah untuk mendeskripsikan perencanaan, pelaksanaan dan evaluasi pengembangan sumber daya manusia di Pondok Pesantren As-Syafaah. Penelitian ini menggunakan pendekatan kualitatif dengan desain studi kasus. Bentuk data dalam penelitian ini adalah data primer dan data sekunder yang diperoleh dari informan dan dokumen pendukung. Analisis data dilakukan dalam beberapa tahap menurut teori Miles, Huberman dan Saldana, yaitu kondensasi data, penyajian data, dan penarikan kesimpulan atau verifikasi. Hasil penelitian menunjukkan bahwa (1) analisis kebutuhan pengembangan sumber daya manusia analisis kualitas dan kuantitas, (2) pelaksanaan pengembangan sumber daya manusia dilakukan melalui rekrutmen, program pendidikan dan pelatihan, dan pembentukan budaya pesantren; (3) evaluasi pengembangan sumber daya manusia dititikberatkan pada perubahan sikap dan perilaku dalam menjalankan peran dan tanggung jawab.
Kata kunci: manajemen, SDM, pesantren

The aim of this is to describe the planning, implementation and evaluation of human resource development at As-syafaah Islamic boarding school. This study used a qualitative approach with case study design. The form of data in this study is primary data and secondary data obtained from informants and supporting documents. Data analysis is carried out in several steps according to Miles, Huberman and Saldana theory, which are data condensation, data display, and drawing conclusions or verification (conclusion drawing and verification). The results shown that (1) analysis of human resource development needs quality and quantity analysis, (2) implementation of human resource development is carried out through recruitment, education and training programs, and the formation of Islamic boarding school culture; (3) evaluation of human resource development is emphasized on changing attitudes and behaviors in carrying out roles and responsibilities
Planar head wave induced by pulsed laser ablation in liquid
Authors: Nguyen Thao Thi Phuong , Tanabe-Yamagishi Rie , Ito Yoshiro 
Published: March 2021

Abstract
We studied the dynamics of nanosecond-pulsed laser ablation of graphite-coated and black-paint-coated targets in liquids using a custom-designed time-resolved photoelasticity imaging technique. We presented the first demonstration of a planar head wave that was almost parallel to the target surface. In the solid, we observed a planar stress wave that was a counterpart of the planar head wave. This planar stress wave distorted the typical stress distribution induced by pulsed laser ablation in liquid. The planar head wave and stress wave traveled at the acoustic speed in the corresponding medium. These wavefronts were stronger as the number of shots increased.