bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of cottonseed bioactive peptides supplementation on performance, egg quality, and total antioxidant activity of serum in laying hens
Authors: Landy Nasir , Kheiri Farshid 
Published: October 2021

Abstract
Background
A study was undertaken to assess the effect of bioactive peptides derived from cottonseed (BPC) supplementation on productive performance, egg quality, and total antioxidant capacity (TAC) of serum and yolk in laying hens. A total of seventy-two 22-week-old Bovans White hens were randomly allocated to 12 cages to have similar cage body weight (1520 ± 5 g). The dietary treatments consist of basal diet (control) and basal diet supplements with 5 g BPC/kg of diet. Recording data initiated after 2 weeks.

Results
In the second week, hens fed diets containing BPC had significantly higher egg mass and egg weight (P < 0.05). Final BW was significantly higher in laying hens fed diets containing BPC (P < 0.05). The percentage of egg white protein as one of the highest quality proteins available was significantly higher in laying hens fed diets supplemented with BPC (P < 0.05). Hens fed diets containing BPC had significantly higher TAC compared with control group (P < 0.05).

Conclusions
The results indicated that addition of BPC to Bovans White hens at peaking period, receiving nutrient adequate diets, could induce favorable influences on egg quality and TAC of egg.
Survey of the African giant land snail (Archachatina marginata), intermediate host of intestinal parasites in Akure Metropolis, Ondo State
Authors: Olusi Titus Adeniyi , Babatunde Olugbenga Samuel , Adeniji Muideen 
Published: October 2021

AbstractBackgroundAfrican giant land snails (Archachatina marginata) are hermaphroditic pulmonate nocturnal gastropods of the Achatinidae family. The snail is one of West Africa's largest known terrestrial snails. The majority of land snails live in Nigeria's derived guinea savannah's forest litters, which range from deep tropical high forest to bordering riparian forests. Africa's giant land snails, which are noted for their ravenous feeding habits and extensive food range, are a major reservoir and intermediate host for parasites that can infect humans.ResultsSeventy snail samples were collected from the study site in total. The parasites found is a nematode rat lung worm (Angiostrongylus cantonensis), which have a fragile, narrow, and simple mouth with no lip or buccal cavity and belong to the order Strongylida. The parasite was found to be most prevalent in small snails (52.94%), followed by medium sized snails with a frequency of 29.41%, and the giant-sized snails with the lowest prevalence of infection. The mantle parasite has the largest prevalence (48.6%), while parasites retrieved from the stomach have the highest mean intensity (2.50 ± 0.25).ConclusionThe African giant land snail can serve as a vector for zoonotic diseases, transmitting parasites to humans through raw or undercooked snails, infested vegetation, and contact with contaminated water. As a result, effective control measures for human infection should be established.
Plasma Levels of Bile Acids Are Related to Cardiometabolic Risk Factors in Young Adults
Authors: Osuna-Prieto Francisco J , Rubio-Lopez José , Di Xinyu , Yang Wei , Kohler Isabelle , Rensen Patrick C N , Ruiz Jonatan R , Martinez-Tellez Borja 
Published: October 2021

Abstract

Context
Bile acids (BA) are known for their role in intestinal lipid absorption and can also play a role as signaling molecules to control energy metabolism. Prior evidence suggests that alterations in circulating BA levels and in the pool of circulating BA are linked to an increased risk of obesity and a higher incidence of type 2 diabetes in middle-aged adults.

Objective
We aimed to investigate the association between plasma levels of BA with cardiometabolic risk factors in a cohort of well-phenotyped, relatively healthy young adults.

Methods
Body composition, brown adipose tissue, serum classical cardiometabolic risk factors, and a set of 8 plasma BA (including glyco-conjugated forms) in 136 young adults (age 22.1 ± 2.2 years, 67% women) were measured.

Results
Plasma levels of chenodeoxycholic acid (CDCA) and glycoursodeoxycholic acid (GUDCA) were higher in men than in women, although these differences disappeared after adjusting for body fat percentage. Furthermore, cholic acid (CA), CDCA, deoxycholic acid (DCA), and glycodeoxycholic acid (GDCA) levels were positively, yet weakly associated, with lean body mass (LBM) levels, while GDCA and glycolithocholic acid (GLCA) levels were negatively associated with 18F-fluorodeoxyglucose uptake by brown adipose tissue. Interestingly, glycocholic acid (GCA), glycochenodeoxycholic acid (GCDCA), and GUDCA were positively associated with glucose and insulin serum levels, HOMA index, low-density lipoprotein cholesterol, tumor necrosis factor alpha, interleukin (IL)-2, and IL-8 levels, but negatively associated with high-density lipoprotein cholesterol, ApoA1, and adiponectin levels, yet these significant correlations partially disappeared after the inclusion of LBM as a confounder.

Conclusion
Our findings indicate that plasma levels of BA might be sex dependent and are associated with cardiometabolic and inflammatory risk factors in young and relatively healthy adults.
Causal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency
Authors: Gorsi Bushra , Hernandez Edgar , Moore Marvin Barry , Moriwaki Mika , Chow Clement Y , Coelho Emily , Taylor Elaine , Lu Claire , Walker Amanda , Touraine Philippe , Nelson Lawrence M , Cooper Amber R , Mardis Elaine R , Rajkovic Aleksander , Yandell Mark , Welt Corrine K 
Published: October 2021

AbstractContextA genetic etiology likely accounts for the majority of unexplained primary ovarian insufficiency (POI).ObjectiveWe hypothesized that heterozygous rare variants and variants in enhanced categories are associated with POI.DesignThe study was an observational study.SettingSubjects were recruited at academic institutions.PatientsSubjects from Boston (n = 98), the National Institutes of Health and Washington University (n = 98), Pittsburgh (n = 20), Italy (n = 43), and France (n = 32) were diagnosed with POI (amenorrhea with an elevated follicle-stimulating hormone level). Controls were recruited for health in old age or were from the 1000 Genomes Project (total n = 233).InterventionWe performed whole exome sequencing (WES), and data were analyzed using a rare variant scoring method and a Bayes factor-based framework for identifying genes harboring pathogenic variants. We performed functional studies on identified genes that were not previously implicated in POI in a D. melanogaster model.Main OutcomeGenes with rare pathogenic variants and gene sets with increased burden of deleterious variants were identified.ResultsCandidate heterozygous variants were identified in known genes and genes with functional evidence. Gene sets with increased burden of deleterious alleles included the categories transcription and translation, DNA damage and repair, meiosis and cell division. Variants were found in novel genes from the enhanced categories. Functional evidence supported 7 new risk genes for POI (USP36, VCP, WDR33, PIWIL3, NPM2, LLGL1, and BOD1L1).ConclusionsCandidate causative variants were identified through WES in women with POI. Aggregating clinical data and genetic risk with a categorical approach may expand the genetic architecture of heterozygous rare gene variants causing risk for POI.
Physician Specialties Involved in Thyroid Cancer Diagnosis and Treatment: Implications for Improving Health Care Disparities
Authors: Radhakrishnan Archana , Reyes-Gastelum David , Abrahamse Paul , Gay Brittany , Hawley Sarah T , Wallner Lauren P , Chen Debbie W , Hamilton Ann S , Ward Kevin C , Haymart Megan R 
Published: October 2021

AbstractContextLittle is known about provider specialties involved in thyroid cancer diagnosis and management.ObjectiveCharacterize providers involved in diagnosing and treating thyroid cancer.Design/Setting/ParticipantsWe surveyed patients with differentiated thyroid cancer from the Georgia and Los Angeles County Surveillance, Epidemiology and End Results registries (N = 2632, 63% response rate). Patients identified their primary care physicians (PCPs), who were also surveyed (N = 162, 56% response rate).Main outcome measures(1) Patient-reported provider involvement (endocrinologist, surgeon, PCP) at diagnosis and treatment; (2) PCP-reported involvement (more vs less) and comfort (more vs less) with discussing diagnosis and treatment.ResultsAmong thyroid cancer patients, 40.6% reported being informed of their diagnosis by their surgeon, 37.9% by their endocrinologist, and 13.5% by their PCP. Patients reported discussing their treatment with their surgeon (71.7%), endocrinologist (69.6%), and PCP (33.3%). Physician specialty involvement in diagnosis and treatment varied by patient race/ethnicity and age. For example, Hispanic patients (vs non-Hispanic White) were more likely to report their PCP informed them of their diagnosis (odds ratio [OR]: 1.68; 95% CI, 1.24-2.27). Patients ≥65 years (vs &lt;45 years) were more likely to discuss treatment with their PCP (OR: 1.59; 95% CI, 1.22-2.08). Although 74% of PCPs reported discussing their patients’ diagnosis and 62% their treatment, only 66% and 48%, respectively, were comfortable doing so.ConclusionsPCPs were involved in thyroid cancer diagnosis and treatment, and their involvement was greater among older patients and patients of minority race/ethnicity. This suggests an opportunity to leverage PCP involvement in thyroid cancer management to improve health and quality of care outcomes for vulnerable patients.
Calcitriol and Levothyroxine Dosing for Patients With Pseudohypoparathyroidism
Authors: Antoun Jacqueline , Williamson Dylan , Hubler Merla , Shoemaker Ashley H 
Published: October 2021

Abstract
Pseudohypoparathyroidism (PHP) is a rare hormone resistance syndrome caused by mutations in GNAS. This cross-sectional study investigated whether PHP patients with parathyroid hormone (PTH), thyrotropin (thyroid stimulating hormone; TSH), and free thyroxine (T4) levels at goal required higher doses of levothyroxine and calcitriol than recommended by current guidelines to overcome mineral ion abnormalities due to hormone resistance.
Baseline demographic and clinical data of participants enrolled in PHP research studies between 2012-2021 were collected via retrospective chart review. Longitudinally, data were recorded at a maximum frequency of once a year starting at 1 year of age. The PTH at goal (PAG) group was defined as PTH &lt; 150 pg/mL and calcium ≥ 8.4 mg/dL, and the TSH and free T4 at goal (TAG) group was defined as TSH &lt; 5 mIU/L and free T4 ≥ 0.8 ng/dL.
The PAG group (n = 74) was prescribed higher calcitriol doses than the PTH not at goal (PNAG) group (n = 50) (0.9 ± 1.1 vs 0.5 ± 0.9 mcg/day, P = 0.04) and 21% of individual patients were prescribed ≥ 1.5 mcg of calcitriol daily. This remained true after normalization for body weight (0.013 ± 0.015 vs 0.0067 ± 0.0095 mcg/kg/day, P = 0.008). There was no statistically significant difference in levothyroxine dosing between the TAG group (n = 122) and TSH and free T4 not at goal (TNAG) group (n = 45) when normalized for weight (2.0 ± 0.7 vs 1.8 ± 0.7 mcg/kg/day, P = 0.2).
More than one-third of patients with PHP had PTH levels not at goal and some patients required calcitriol doses ≥ 1.5 mcg/day to meet current treatment goals.
Dopamine-Secreting Pheochromocytoma and Paraganglioma
Authors: Miyamoto Shotaro , Yoshida Yuichi , Ozeki Yoshinori , Okamoto Mitsuhiro , Gotoh Koro , Masaki Takayuki , Nishida Haruto , Shibuya Tadamasa , Shin Toshitaka , Daa Tsutomu , Mimata Hiromitsu , Kimura Noriko , Shibata Hirotaka 
Published: October 2021

Abstract
Predominantly or exclusively dopamine-secreting pheochromocytoma and paraganglioma are very rare. We report a 64-year-old woman with an adrenal incidentaloma. She was normotensive and had no symptoms of catecholamine excess. The 24-hour urine catecholamine level showed normal norepinephrine (122.9 μg/day), normal epinephrine (24.3 μg/day), and markedly elevated dopamine (148 212.4 μg/day). 123I-metaiodobenzylguanidine (MIBG) scintigraphy revealed tumor uptake. After α-blockade as preoperative management, she successfully underwent laparoscopic left adrenalectomy and was finally diagnosed with an exclusively dopamine-secreting pheochromocytoma. The tumor was histologically comprised of small polygonal cells with high cellularity and was immunohistochemically positive for all 3 catecholamine-synthesizing enzymes: tyrosine hydroxylase (very weak), dopamine β-hydroxylase (heterogeneous), and phenylethanolamine N-methyltransferase (very weak). Electron microscopy revealed very few catecholamine-containing small vesicles with a few organelles, which reflected immature cells. No biochemical or imaging evidence of recurrence or metastasis were evident 1 year after the surgery. We conducted a literature search in the PubMed database. A total of 33 cases were collected. Our case had the second-highest 24-hour urinary dopamine excretion and was the first in which immunostaining for catecholamine synthase and electron microscopy were performed together. Histological findings in our case give a possible hypothesis that the mechanism underlying a dopamine-secreting pheochromocytoma is associated with immature catecholamine vesicles in which dopamine β-hydroxylase is localized, thus resulting in inhibited conversion from dopamine to norepinephrine. We also discuss the reasons for the lack of catecholamine excess symptoms, whether preoperative management of α-blockade is needed, and the association between the prognosis and genetic mutation, with an extensive literature review.
Non-Small-Cell Lung Cancer Patients with a High Predicted Risk of Irradical Resection: Can Chemoradiotherapy Offer Similar Survival?
Authors: van Joolingen W. Hugo , Rasing Marnix J. A. , Peters Max , van Lindert Anne S. R. , de Heer Linda M. , Aarts Mieke J. , Verhoeff Joost J. C. , van Rossum Peter S. N. 
Published: October 2021

Abstract
Purpose
Irradical resection of non-small-cell lung cancer (NSCLC) is a detrimental prognostic factor. Recently, Rasing et al. presented an internationally validated risk score for pre-treatment prediction of irradical resection. We hypothesized that chemoradiation therapy (CRT) could serve as an alternative approach in patients with a high risk score and compared overall survival (OS) outcomes between surgery and CRT.

Methods
Patients from a population-based cohort with stage IIB–III NSCLC between 2015 and 2018 in The Netherlands were selected. Patients with a ‘Rasing score’ > 4 who underwent surgery were matched with patients who underwent CRT using 1:1 nearest-neighbor propensity score matching. The primary endpoint of OS was compared using a Kaplan–Meier analysis.

Results
In total, 2582 CRT and 638 surgery patients were eligible. After matching, 523 well-balanced pairs remained. Median OS in the CRT group was 27.5 months, compared with 45.6 months in the surgery group (HR 1.44, 95% CI 1.23–1.70, p < 0.001). The 114 surgical patients who underwent an R1–2 resection (21.8%) had a worse median OS than the CRT group (20.2 versus 27.5 months, HR 0.77, 95% CI 0.61–0.99, p = 0.039).

Conclusion
In NSCLC patients at high predicted risk of irradical resection, CRT appears to yield inferior survival compared with surgery. Therefore, choosing CRT instead of surgery cannot solely be based on the Rasing score. Since patients receiving an R1–2 resection do have detrimental outcomes compared with primary CRT, the treatment decision should be based on additional information, such as imaging features, comorbidities, patient preference, and the surgeon’s confidence in achieving an R0 resection.
On reducible non-Weierstrass semigroups
Authors: García-García Juan Ignacio , Marín-Aragón Daniel , Torres Fernando , Vigneron-Tenorio Alberto 
Published: October 2021

Abstract
Weierstrass semigroups are well known along the literature. We present a new family of non-Weierstrass semigroups which can be written as an intersection of Weierstrass semigroups. In addition, we provide methods for computing non-Weierstrass semigroups with genus as large as desired.
Apakah Terjadi Perpindahan Simpanan Nasabah Bank Kecil Ke Bank Besar (Flight to Quality) Pada Saat Krisis Pandemi Covid-19?
Authors: Ashari Hasan , Nugrahanti Trinandari Prasetyo 
Published: October 2021

This paper aims to explain whether flight to quality or the transfer of deposit funds from small banks to large banks actually occurred during the Covid-19 pandemic crisis as suspected by banking analysts. This research is descriptive research with a quantitative approach. The secondary data source in this study was obtained from the website of the Indonesia Deposit Insurance Corporation which lists the value of Commercial Bank Deposits from July 2013 to d. July 2020. Analysis of the data using panel data regression analysis. The results of this study conclude that 1) the Covid-19 pandemic does not significantly affect the performance of small banks in collecting deposits, 2) the Covid-19 pandemic causes flight to quality small bank deposits, namely Book 1 banks, Islamic banks, and regional banks to category banks. others who have large assets and 3) Economic growth does not affect the performance of small banks in collecting deposits during the Covid-19 Pandemic.How to Cite:Ashari, H., & Nugrahanti, T. P. (2021). Apakah Terjadi Perpindahan Simpanan Nasabah Bank Kecil ke Bank Besar (Flight to Quality) Pada Saat Krisis Pandemi Covid-19? Akuntabilitas: Jurnal Ilmu Akuntansi, 14(2), 215-230.
Analisis Model Atas Faktor Penentu Nilai Perusahaan (Studi Pada Perusahaan Pulp and Paper yang Terdaftar di BEI 2015-2019)
Authors: Fernando William , Setiawan Temy 
Published: October 2021

This study aims to analyze the factors that influence firm value, where the independent variables consist of ownership structure, capital structure and gender diversity, and financial performance as a mediation. The research used is Pulp & Paper companies listed on the Indonesia Stock Exchange for the period 2015 – 2019. Using samples from 7 manufacturing companies. By using a sample of 7 manufacturing companies. The test analysis used is the SmartPLS 3.0 program. Based on the results of the study, ownership structure and gender diversity have no significant effect on firm value, capital structure and financial performance have a significant positive effect on firm value, and financial performance has no significant effect on mediating ownership structure and capital structure on the firm. The limitation of this study is to use financial reports sourced from the Indonesia Stock Exchange (IDX) for the pulp and paper sector from 2015-2019 and have financial reports for 5 consecutive years. The implications of this research are expected to provide information for investors on things that can affect the value of the company, especially the paper industry sector.How to Cite:Fernando, W., & Setiawan, T. (2021). Analisis Model Atas Faktor Penentu Nilai Perusahan (Studi Pada Perusahaan Pulp and Paper yang Terdaftar di BEI 2015-2019). Akuntabilitas: Jurnal Ilmu Akuntansi, 14(2), 231-242.
Executive Compensation, Executive Character, Audit Committee, and Audit Quality on Tax Avoidance
Authors: Ardillah Kenny , Prasetyo C Agus 
Published: October 2021

Tax avoidance turns into become most part satisfactory tax assessment practice, despite the fact that the practice isn’t in opposition to the law that can’t be acknowledged , should be forestalled, and gone against. This study expect to inform the impact of executive compensation, executive character, audit committee and audit quality on tax avoidance of mining companies listed on the Indonesia Stock Exchange. The sample selection method in this study uses purposive sampling. The sample of this study is mining companies listed on the Indonesia Stock Exchange. The data analysis technique used in this study is multiple linear regression. The results of this study proved that executive character has positive effect on tax avoidance and executive compensation, audit committee, and audit quality have no effect on tax avoidance. This research is required to be the reason for decision making by the management to not to rehearse tax avoidance and make thought for investor to not settle on speculation choices dependently on the evaluation of corporate governance perspectives that don’t influence the organization in carrying out tax avoidance practice.How to Cite:Ardillah, K., & Prasetyo C, A. (2021). Executive Compensation, Executive Character, Audit Committee, and Audit Quality on Tax Avoidance. Akuntabilitas: Jurnal Ilmu Akuntansi, 14(2), 169-186.
Faktor-Faktor Yang Mempengaruhi Fraudulent Financial Reporting
Authors: Sari Wulanda Maya , Irawati Anik 
Published: October 2021

This study aims to empirically prove the influence of financial stability, external pressure, and ineffective monitoring on fraudulent financial reporting. Financial stability was measured using a comparison of total assets. External pressure was measured using leverage. Meanwhile, ineffective monitoring was measured using the ratio of independent commissioners’ number. The dependent variable in this study was fraudulent financial reporting. It was measured using the F-Score Model. The sample in this study were 21 State Owned Enterprises (BUMN) listed on Indonesia Stock Exchange in period of 2017-2019. The data analysis method used in this study was Logistic Regression using SPSS software version 20. The results of this study indicate that financial stability has no influence on fraudulent financial reporting. Meanwhile, external pressure and ineffective monitoring influence fraudulent financial reporting.How to cite:Sari, W. M., & Irawati, A. (2021). Faktor-faktor yang Mempengaruhi Fraudulent Financial Reporting. Akuntabilitas: Jurnal Ilmu Akuntansi, 14(2), 139-152.
On square Tribonacci Lucas numbers
Authors: IRMAK Nurettin 
Published: October 2021

The Tribonacci-Lucas sequence {Sn}{Sn} is defined by the recurrence relation Sn+3=Sn+2+Sn+1+SnSn+3=Sn+2+Sn+1+Sn with S0=3, S1=1, S2=3.S0=3, S1=1, S2=3. In this note, we show that 11 is the only perfect square in Tribonacci-Lucas sequence for n≢1(mod32)n≢1(mod32) and n≢17(mod96).n≢17(mod96).
İslam Dünyasında Kâğıt Üretiminin Elyazmalarındaki Resimlere Yansıması
Authors: TEZCAN KAYA Gülsen 
Published: October 2021

Medeniyetlerin oluşmasıyla birlikte bilim kültür ve sanatın aktarımında en önemli araçlardan biri şüphesiz yazıdır. Bu nedenle her nereye ve ne şekilde yazılırsa yazılsın nesiller bundan yararlanmışlar, kendi kültür ve tarihlerini yakından tanıyabilmişler ve gelecek kuşaklara da miras bırakabilmişlerdir. Ancak bu mirasın aktarılmasını daha da kolaylaştıracak bir malzeme olan kâğıdın icadı, işleri oldukça hızlandırmıştır. Gerek bilgi aktarımında kullanılan gerekse bizzat sanatın üzerine işlendiği kâğıt hem doğu hem de batıda vazgeçilmez bir malzeme olarak karşımıza çıkar. Kâğıdın keşfiyle beraber, medeniyetlerin onu elde ettikleri hammaddeler de coğrafya ve yüzyıla göre farklılık göstermiş, türleri, ticarî ilişkiler ve kullanım kolaylıklarına bağlı olarak batı ve doğu arasında sürekli yer değiştirmiştir.
Bu araştırmada genel olarak kâğıdın tarihi serüveni ve hammaddeleri üzerinde durularak, İslam coğrafyasında farklı yüzyıllarda, kitap üretim merkezlerindeki kâğıt yapım aşamalarını gösteren tasvirler üzerinden, kitabhânelerdeki üretim faaliyetlerini gözler önüne sermek amaçlanmıştır.
Özellikle 15. yüzyıl sonunda Herat’ta Timurlu döneminde günlük yaşam sahnelerinin resimlerde yer bulmasıyla, edebî eserlerde medrese konulu resimlerde kâğıdı hazırlayan kişiler görülmeye başlanmış, 16. yüzyılda Safevi döneminde bu etki devam etmiş, sonrasında Babürlü dönemiyle de risalelerde saray kitabhânelerinin canlandırıldığı resimlerle ve albümlerde sayfa kenarı süslemesi olarak görülmüştür. Bu tasvirlere bakıldığında, kâğıt yapım aşamaları ve üretimde kullanılan aletler, dönemin kaynaklarını destekler biçimde yansıtılmıştır.