bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immediate post-procedural functional assessment of percutaneous coronary intervention: current evidence and future directions
Authors: Ding Daixin , Huang Jiayue , Westra Jelmer , Cohen David Joel , Chen Yundai , Andersen Birgitte Krogsgaard , Holm Niels Ramsing , Xu Bo , Tu Shengxian , Wijns William 
Published: March 2021

Abstract
Percutaneous coronary intervention (PCI) guided by coronary physiology provides symptomatic benefit and improves patient outcomes. Nevertheless, over one-fourth of patients still experience recurrent angina or major adverse cardiac events following the index procedure. Coronary angiography, the current workhorse for evaluating PCI efficacy, has limited ability to identify suboptimal PCI results. Accumulating evidence supports the usefulness of immediate post-procedural functional assessment. This review discusses the incidence and possible mechanisms behind a suboptimal physiology immediately after PCI. Furthermore, we summarize the current evidence base supporting the usefulness of immediate post-PCI functional assessment for evaluating PCI effectiveness, guiding PCI optimization, and predicting clinical outcomes. Multiple observational studies and post hoc analyses of datasets from randomized trials demonstrated that higher post-PCI functional results are associated with better clinical outcomes as well as a reduced rate of residual angina and repeat revascularization. As such, post-PCI functional assessment is anticipated to impact patient management, secondary prevention, and resource utilization. Pre-PCI physiological guidance has been shown to improve clinical outcomes and reduce health care costs. Whether similar benefits can be achieved using post-PCI physiological assessment requires evaluation in randomized clinical outcome trials.
Communicating uncertainty: contrasting the communication experiences of patients with advanced COPD and incurable lung cancer
Authors: Ngwenya Nothando , Crang Clare , Farquhar Morag , Rintoul Robert C , Mahadeva Ravi , Calvert Lori D , Murray Scott A , Barclay Stephen 
Published: March 2021

Abstract

Background
Due to the uncertain disease trajectory and variable rate of progression in chronic obstructive pulmonary disease (COPD), health care professionals (HCPs) are challenged in explaining what the future may hold for patients compared to those with lung cancer (LC). Support and communication of timely information can significantly improve health outcomes.

Objective
This study sought to identify factors that impact communication and support and recommend ways to improve patients’ understanding of living with life-threatening illness.

Methods
Semi-structured interviews with patients with LC (n = 22) and advanced COPD (n = 18), their informal carers (21 LC and 18 COPD) and HCPs (n = 51). Patients were recruited from primary and secondary care in the East of England, UK, during 2010–12.

Results
Directness and clarity characterized communication in LC, whereas uncertainty and limited explanations predominated in COPD. Discussions on how the disease might impact on decisions and preferences to be made in the future were less common in COPD. Information for LC patients was mainly from hospital clinicians and any information for COPD patients mainly from primary care clinicians.

Conclusions
The experience of COPD patients could be improved by professionals soon after diagnosis explaining to them the typical pattern of decline in COPD, highlighting the inherent uncertainties about when exacerbations and death may occur. This conversation should lead to planning for the different challenges that the patient and informal carer recognize as most important to them. This contrasts with the ‘breaking bad news’ conversation that oncologists are highly trained to deliver.
Genomic analysis of dibenzofuran-degradingPseudomonas veroniistrain Pvy reveals its biodegradative versatility
Authors: Lopez-Echartea Eglantina , Suman Jachym , Smrhova Tereza , Ridl Jakub , Pajer Petr , Strejcek Michal , Uhlik Ondrej 
Published: March 2021

AbstractCertain industrial chemicals accumulate in the environment due to their recalcitrant properties. Bioremediation uses the capability of some environmental bacteria to break down these chemicals and attenuate the pollution. One such bacterial strain, designated Pvy, was isolated from sediment samples from a lagoon in Romania located near an oil refinery due to its capacity to degrade dibenzofuran (DF). The genome sequence of the Pvy strain was obtained using an Oxford Nanopore MiniION platform. According to the consensus 16S rRNA gene sequence that was compiled from six 16S rRNA gene copies contained in the genome and orthologous average nucleotide identity (OrthoANI) calculation, the Pvy strain was identified as Pseudomonas veronii, which confirmed the identification obtained with the aid of MALDI-TOF mass spectrometry and MALDI BioTyper. The genome was analyzed with respect to enzymes responsible for the overall biodegradative versatility of the strain. The Pvy strain was able to derive carbon from naphthalene (NP) and several aromatic compounds of natural origin, including salicylic, protocatechuic, p-hydroxybenzoic, trans-cinnamic, vanillic, and indoleacetic acids or vanillin, and was shown to degrade but not utilize DF. In total seven loci were found in the Pvy genome, which enables the strain to participate in the degradation of these aromatic compounds. Our experimental data also indicate that the transcription of the NP-dioxygenase α-subunit gene (ndoB), carried by the plasmid of the Pvy strain, is inducible by DF. These features make the Pvy strain a potential candidate for various bioremediation applications.
Prediction of count phenotypes using high-resolution images and genomic data
Authors: Kismiantini  , Montesinos-López Osval Antonio , Crossa José , Setiawan Ezra Putranda , Wutsqa Dhoriva Urwatul 
Published: March 2021

AbstractGenomic selection (GS) is revolutionizing plant breeding since the selection process is done with the help of statistical machine learning methods. A model is trained with a reference population and then it is used for predicting the candidate individuals available in the testing set. However, given that breeding phenotypic values are very noisy, new models must be able to integrate not only genotypic and environmental data but also high-resolution images that have been collected by breeders with advanced image technology. For this reason, this paper explores the use of generalized Poisson regression (GPR) for genome-enabled prediction of count phenotypes using genomic and hyperspectral images. The GPR model allows integrating input information of many sources like environments, genomic data, high resolution data, and interaction terms between these three sources. We found that the best prediction performance was obtained when the three sources of information were taken into account in the predictor, and those measures of high-resolution images close to the harvest day provided the best prediction performance.
Genome-wide identification of microRNAs involved in the somatic embryogenesis of Eucalyptus
Authors: Qin Zihai , Li Junji , Zhang Ye , Xiao Yufei , Zhang Xiaoning , Zhong Lianxiang , Liu Hailong , Chen Bowen 
Published: March 2021

Abstract
MicroRNAs (miRNAs) are small noncoding RNAs (18–24 nt) and function in many biological processes in plants. Although Eucalyptus trees are widely planted across the world, our understanding of the miRNA regulation in the somatic embryogenesis (SE) of Eucalyptus is still poor. Here we reported, for the first time, the miRNA profiles of differentiated and dedifferentiated tissues of two Eucalyptus species and identified miRNAs involved in SE of Eucalyptus. Stem and tissue culture–induced callus were obtained from the subculture seedlings of E. camaldulensis and E. grandis x urophylla and were used as differentiated and dedifferentiated samples, respectively. Small RNA sequencing generated 304.2 million clean reads for the Eucalyptus samples (n = 3) and identified 888 miRNA precursors (197 known and 691 novel) for Eucalyptus. These miRNAs were mainly distributed in chromosomes Chr03, Chr05, and Chr08 and can produce 46 miRNA clusters. Then, we identified 327 and 343 differentially expressed miRNAs (DEmiRs) in the dedifferentiation process of E. camaldulensis and E. grandis x urophylla, respectively. DEmiRs shared by the two Eucalyptus species might be involved in the development of embryonic callus, such as MIR156, MIR159, MIR160, MIR164, MIR166, MIR169, MIR171, MIR399, and MIR482. Notably, we identified 81 upregulated and 67 downregulated miRNAs specific to E. camaldulensis, which might be associated with the high embryogenic potential. Target prediction and functional analysis showed that they might be involved in longevity regulating and plant hormone signal transduction pathways. Further, using the gene expression profiles, we observed the negative regulation of miRNA–target pairs, such as MIR160~ARF18, MIR396~GRF6, MIR166~ATHB15/HD-ZIP, and MIR156/MIR157~SPL1. Interestingly, transcription factors such as WRKY, MYB, GAMYB, TCP4, and PIL1 were found to be regulated by the DEmiRs. The genes encoding PIL1 and RPS21C, regulated by upregulated miRNAs (e.g., egd-N-miR63-5p, egd-N-miR63-5p, and MIR169,) were downregulated exclusively in the dedifferentiation of E. camaldulensis. This is the first time to study the miRNA regulation in the dedifferentiation process of Eucalyptus and it will provide a valuable resource for future studies. More importantly, it will improve our understanding of miRNA regulation during the somatic embryogenesis of Eucalyptus and benefit the Eucalyptus breeding program.
New Changes, New Possibilities: China’s Latest Patent Law Amendments
Authors: Yu Ronald , Yip Kenneth 
Published: March 2021

Abstract
New amendments to China’s Patent Law feature open licensing which should encourage the use of patents, and promote the more rapid broadcast and dissemination of new technology. They should also offer the possibility of greater transactional visibility, transparency and traceability which has important ramifications for IP valuation and reporting in IPOs, annual and other reports. Other provisions underscore China’s efforts to improve its patent system by introducing new protections for patent holders, mechanisms to reduce abuse, provisions to strengthen patent-related public services and promote the use of patents. There are also a number of changes that should interest pharmaceutical companies, patent litigants, patent holders and app developers.
Implementation of preventive measures to prevent COVID-19: a national study of English primary schools in summer 2020
Authors: Sundaram Neisha , Bonell Chris , Ladhani Shamez , Langan Sinéad M , Baawuah Frances , Okike Ifeanychukwu , Ahmad Shazaad , Beckmann Joanne , Garstang Joanna , Brent Bernadette E , Brent Andrew J , Amin-Chowdhury Zahin , Aiano Felicity , Hargreaves James 
Published: March 2021

Abstract
We examined the feasibility of implementing preventive measures to prevent SARS-CoV-2 transmission across 105 English primary schools in summer 2020 via a survey and interviews with headteachers. High rates of implementation of most recommended measures were noted with the exception of requiring 2 m distance for students, fitting hand sanitizers in classrooms and introducing one-way systems in school corridors. Measures such as regular handwashing and stopping assemblies were considered easy to implement. Majorly challenging measures included distancing between individuals (for students: 51%, N = 99; for staff: 34%; N = 98; for parents: 26%, N = 100), spacing out desks (34%, N = 99), keeping same staff assigned to each student group (33%, N = 97) and staggering break times (25%, N = 99). Rapid implementation was facilitated by staff commitment and communication among stakeholders, but hampered by limitations with guidance received, physical environments, resources, parental adherence and balancing preventive measures with learning. Difficulties with distancing for younger children suggest that smaller bubbles with fewer distancing requirements within these may be a policy option. Schools require further financial, human resource and other support for effective implementation of preventive measures.
Reduced FSH and LH action: implications for medically assisted reproduction
Authors: Bosch E , Alviggi C , Lispi M , Conforti A , Hanyaloglu A C , Chuderland D , Simoni M , Raine-Fenning N , Crépieux P , Kol S , Rochira V , D'Hooghe T , Humaidan P 
Published: March 2021

ABSTRACT
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) play complementary roles in follicle development and ovulation via a complex interaction in the hypothalamus, anterior pituitary gland, reproductive organs, and oocytes. Impairment of the production or action of gonadotropins causes relative or absolute LH and FSH deficiency that compromises gametogenesis and gonadal steroid production, thereby reducing fertility. In women, LH and FSH deficiency is a spectrum of conditions with different functional or organic causes that are characterized by low or normal gonadotropin levels and low oestradiol levels. While the causes and effects of reduced LH and FSH production are very well known, the notion of reduced action has received less attention by researchers. Recent evidence shows that molecular characteristics, signalling as well as ageing, and some polymorphisms negatively affect gonadotropin action. These findings have important clinical implications, in particular for medically assisted reproduction in which diminished action determined by the afore-mentioned factors, combined with reduced endogenous gonadotropin production caused by GnRH analogue protocols, may lead to resistance to gonadotropins and, thus, to an unexpected hypo-response to ovarian stimulation. Indeed, the importance of LH and FSH action has been highlighted by the International Committee for Monitoring Assisted Reproduction Technologies (ICMART) in their definition of hypogonadotropic hypogonadism as gonadal failure associated with reduced gametogenesis and gonadal steroid production due to reduced gonadotropin production or action. The aim of this review is to provide an overview of determinants of reduced FSH and LH action that are associated with a reduced response to ovarian stimulation.
Emotions and EU foreign policy
Authors: Smith Karen E 
Published: March 2021

Abstract
This article assesses the role that emotions play in European Union foreign policy-making. EU decision-making has often been depicted as technocratic and ‘de-dramatized’, yet there are still situations in which emotions can affect the process and outcomes of foreign policy decision-making. Using examples of the EU's responses to crises in Ukraine and Myanmar, the article illustrates that emotions can motivate the taking of particular decisions at particular times. Further, the EU expresses emotions in its foreign policy communications, although its use of emotional diplomacy may not be accompanied by substantive action appropriate to the emotions expressed, thus revealing the existence of an emotions–action gap. The ‘emotional turn’ in foreign policy analysis can open up new directions for research in EU foreign policy, and the conclusion considers other promising avenues for researching emotions and EU foreign policy.
Charismatic leadership in foreign policy
Authors: Wivel Anders , Grøn Caroline Howard 
Published: March 2021

Abstract
Charismatic leadership is an integral yet understudied aspect of foreign policy in liberal democratic states. Combining insights from recent developments on charismatic leadership in organization and management studies with literature on foreign policy, we construct a novel theoretical framework for understanding how foreign policy leaders exercise charismatic leadership. We argue that charismatic leadership makes sense of who ‘we’ are and where we are going through communicative practices. We specify these practices and discuss why charismatic leadership is important in foreign policy analysis; what it is; and how and why sense-making matters for a charismatic leadership style. We contribute with new empirical knowledge by probing our theoretical propositions in a comparative case-study of the charismatic leadership practices of Donald Trump and Angela Merkel. The case-studies illustrate the importance of charismatic communication for both leaders, while disclosing variations in both the ‘thickness’ of charismatic leadership practices and their compatibility with rational legal authority and liberal democratic values.
Surface selection of haddock and cod in the Norwegian demersal seine fisheries
Authors: Ingólfsson Ólafur Arnar , Humborstad Odd-Børre , Løkkeborg Svein 
Published: March 2021

Abstract
Size selection in active fishing gears is a continuous process and undersized fish may escape during the whole fishing operation. Fish that escape during the surface hauling operation are likely to experience higher mortality due to barotrauma-related stress than fish escaping at the fishing depth during the towing process. A well-functioning selectivity device should therefore select mostly at depth for enhancing survival probabilities of escaping fish. The current gear regulation in the Norwegian demersal seine fishery is likely to cause large proportion of undersized fish to escape at the surface. In this study, we estimated surface selection of haddock and cod in demersal seine by using an automatic release system and a small meshed codend that collected fish escaping during surface hauling. The collecting bag contained 19% undersized haddock compared to 10% in the conventional square-mesh codend indicating that about 50% of undersized haddock brought to the surface were released. The proportions of undersized cod were 8% for the collecting bag and 1% for the conventional square-mesh codend. These results demonstrate that surface selection is significant for both haddock and cod. Based on this finding, we discuss methods to improve size selectivity at the fishing depth.
Energy saving strategy for residential buildings: case study in Armenia
Authors: Papoyan Atanes , Zhan Changhong , Han Xueying , Li Guanghao 
Published: March 2021

Abstract
In this article the research is concentrated on defining the possibility and potentials of design to enhance the energy efficiency and refine the climate conditions in the existing residential buildings in Armenia. The digital model of existing residential building is used to calculate the annual energy consumption, by simulation software—Autodesk Green Building Student. The horizontal solar panel systems offered by local market leaders were applied to calculate the annual savings, the required installation area, prices, etc. Consequently, the actual efficiency of energy saving technological process of residential buildings in Armenia is estimated. Based on the applied strategies and obtained fact, some recommendations are made for residential buildings. This article is intended to help and to be stimulus for architects and constructors to consider and include green technologies in their new projects.
Estimation of tourism carbon footprint and carbon capacity
Authors: Huang Tianyue , Tang Zi 
Published: March 2021

Abstract
The calculation of tourism carbon footprint is of great significance to low-carbon tourism. This study estimates the tourism carbon footprint in Heilongjiang Province from 2009 to 2018 by using tourism carbon footprint and tourism carbon capacity models. The results show that the total tourism carbon footprint of Heilongjiang Province increased fast to 2.97 times from 5.926million tons in 2009 to 21.13million tons in 2018, while its per capita tourism carbon footprint increased from 53.9 kg to 116.0 kg. During the same period, tourism carbon capacity continued to grow steadily from 15.18billion tons to 21.96billion tons, and the growth rate was 50% of the growth rate of tourism carbon footprint. Tourism carbon emissions can be absorbed by environmental capacity, and the risk of carbon deficit is relatively small.
On the Generalized Bykovskiĭ Presentation of Steinberg Modules
Authors: Kupers Alexander , Miller Jeremy , Patzt Peter , Wilson Jennifer C H 
Published: March 2021

Abstract
We study presentations of the virtual dualizing modules of special linear groups of number rings, the Steinberg modules. Bykovskiĭ gave a presentation for the Steinberg modules of the integers, and our main result is a generalization of this to the Gaussian integers and the Eisenstein integers. We also show that this generalization does not give a presentation for the Steinberg modules of several Euclidean number rings.
Tensor Structure on the Kazhdan–Lusztig Category for Affine 𝔤𝔩(1|1)
Authors: Creutzig Thomas , McRae Robert , Yang Jinwei 
Published: March 2021

AbstractWe show that the Kazhdan–Lusztig category $KL_k$ of level-$k$ finite-length modules with highest-weight composition factors for the affine Lie superalgebra $\widehat{\mathfrak{gl}(1|1)}$ has vertex algebraic braided tensor supercategory structure and that its full subcategory $\mathcal{O}_k^{fin}$ of objects with semisimple Cartan subalgebra actions is a tensor subcategory. We show that every simple $\widehat{\mathfrak{gl}(1|1)}$-module in $KL_k$ has a projective cover in ${\mathcal{O}}_k^{fin}$, and we determine all fusion rules involving simple and projective objects in ${\mathcal{O}}_k^{fin}$. Then using Knizhnik–Zamolodchikov equations, we prove that $KL_k$ and $\mathcal{O}_k^{fin}$ are rigid. As an application of the tensor supercategory structure on $\mathcal{O}_k^{fin}$, we study certain module categories for the affine Lie superalgebra $\widehat{\mathfrak{sl}(2|1)}$ at levels $1$ and $-\frac{1}{2}$. In particular, we obtain a tensor category of $\widehat{\mathfrak{sl}(2|1)}$-modules at level $-\frac{1}{2}$ that includes relaxed highest-weight modules and their images under spectral flow.
Durability of Viral Neutralization in Asymptomatic Coronavirus Disease 2019 for at Least 60 Days
Authors: Haymond Amanda , Damluji Abdulla A , Narayanan Aarthi , Mueller Claudius , Reeder Alex , Alem Farhang , Maxwell G Larry , Petricoin Emanuel F , Liotta Lance , deFilippi Christopher R 
Published: March 2021

AbstractA cohort consisting of asymptomatic healthcare workers donated temporal serum samples after infection with severe acute respiratory syndrome coronavirus 2. Analysis shows that all asymptomatic healthcare workers had neutralizing antibodies, that these antibodies persist for ≥60 days, and that anti-spike receptor-binding domain immunoglobulin G levels were correspondingly durable over the same time period.