bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the impact of validated handover protocols on treatment outcomes in polytrauma patients: a systematic review
Authors: Steinfeld Eva , Dahms Karolina , Dormann Julia , Ansems Kelly , Janka Heidrun , Inti-Metzendorf Maria , Marx Gernot , Benstoem Carina , Breuer Thomas 
Published: February 2025

Abstract

Purpose
Effective patient handovers in healthcare settings are critical for ensuring patient safety and care quality. Handover tools have gained prominence as potential aids in improving these transitions. This systematic review seeks to answer the question if the use of validated handover protocols leads to better treatment outcomes in polytrauma patients compared to no use of validated handover protocols.

Methods
We searched PubMed, Cochrane Central Register of Controlled Trials and Web of Science to identify relevant studies from inception of each database to June 15, 2022. We intended to include systematic reviews and randomized controlled trials comparing the use of validated handover tools to no use of such tools in adult polytrauma patients.

Results
Despite the absence of systematic reviews and RCTs meeting our criteria, we included 26 initially excluded studies to glean insights into handover tool usage. This broader inclusion facilitated the identification of two categories of tools: standardized tools and customized tools. Among studies employing customized tools, positive outcomes were reported in various aspects, including enhanced information quality, improved staff communication, and reduced risks and treatment errors. In contrast, studies utilizing well-established standardized tools documented improvements in communication, documentation, and overall satisfaction among medical professionals, signaling a reduction in communication errors and lost information.

Conclusion
Heterogeneity of the studies and no trials meeting our eligibility criteria present challenges for conducting a traditional systematic review. In the lack of evidence from RCTs and systematic reviews, our analysis of the available studies sheds light on the complexities of assessing handover tools’ utility, especially in diverse clinical settings. It highlights the need for more standardized methodologies and further investigation into the effectiveness of custom-designed tools. It emphasizes the importance of understanding the role of handover tools in healthcare. While some studies suggest positive outcomes, further research is necessary to elucidate the design and implementation of these tools to enhance care and support healthcare professionals in their roles.
From pre-culture to solvent: current trends in Clostridium acetobutylicum cultivation
Authors: Oehlenschläger Katharina , Hengsbach Jan-Niklas , Volkmar Marianne , Ulber Roland 
Published: February 2025

Abstract
The biological production of butanol via ABE (acetone-butanol-ethanol) fermentation using Clostridium acetobutylicum has a storied history of over 100 years, initially driven by the demand for synthetic rubber during World War I and later for industrial applications. Despite its decline due to the rise of petrochemical alternatives, renewed interest has emerged due to the global shift towards sustainable energy sources and rising oil prices. This review highlights the challenges in the cultivation process of C. acetobutylicum, such as strain degeneration, solvent toxicity, and substrate costs, and presents recent advancements aimed at overcoming these issues. Detailed documentation of the entire cultivation process including cell conservation, pre-culture, and main culture is seen as a fundamental step to facilitate further progress in research. Key strategies to improve production efficiency were identified as controlling pH to facilitate the metabolic shift from acidogenesis to solventogenesis, employing in situ product removal techniques, and advancing metabolic engineering for improved solvent tolerance of C. acetobutylicum. Furthermore, the use of renewable resources, particularly lignocellulosic biomass, positions ABE fermentation as a viable solution for sustainable solvent production. By focusing on innovative research avenues, including co-cultivation and bioelectrochemical systems, the potential for C. acetobutylicum to contribute significantly to a bio-based economy can be realized.

Key points

• Historical significance and revival of ABE fermentation with Clostridium acetobutylicum

• Current challenges and innovative solutions in cultivating C. acetobutylicum

• New avenues for enhancing productivity and sustainability
Scroll Ligament Repair in Dorsal Preservation Rhinoplasty: A Cartilage as a Guide on Nasal Skin Envelope for Suturing
Authors: Tuluy Yavuz , Çelik Vasfi , Parspancı Aziz , Sır Emin 
Published: February 2025

Abstract

Background
The scroll ligament provides support to the internal and external valve, and its repair in rhinoplasty provides good functional and aesthetic results. In this study, it was aimed to repair the scroll ligament complex by leaving cartilage in the nasal skin envelope, and clinical results were shared.

Patients and Methods
216 patients who underwent closed preservation rhinoplasty with modified low septal strip septoplasty were included in the study. A 10 x 1 mm of cartilage is left in the nasal skin envelope at the midpoint of the cranial part of the lateral crus of the LLC, leaving it as a guide to repair the scroll ligament complex in the anatomically correct place. Demographic data, complications, revision surgeries, follow-up periods and satisfaction of the patients were analyzed retrospectively.

Results
Residual humps were observed in 2 patients. Inferior turbinate hypertrophy was observed in 4 patients. In 1 patient, total septal reconstruction was performed. Two hundred and three patients were evaluated the results as poor, moderate, good and very good. One hundred and sixteen patients rated the functional outcome as very good, 80 patients as good, 4 patients as moderate and 3 patients as poor. One hundred and twenty-eight patients rated the aesthetic result as very good, 72 as good and 3 as moderate.

Conclusion
Repairing the scroll ligament complex provides both internal and external valve support, better redraping and eliminating the dead space. Leaving cartilage on the nasal skin envelope as a guide helps to repair the scroll ligament complex in the anatomically correct place at the end of the surgery.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Dietary climate impact correlates ambiguously with health biomarkers– a randomised controlled trial in healthy Finnish adults
Authors: Saarinen Merja , Pellinen Tiina , Kostensalo Joel , Nousiainen Jouni , Joensuu Katri , Itkonen Suvi T. , Pajari Anne-Maria 
Published: February 2025

Abstract

Purpose
A transition to more plant-rich diets is an effective way to reduce the climate impact of a diet. Using a whole-diet approach, we studied how partial replacement of animal-sourced with plant-sourced proteins affected the dietary climate impact while simultaneously considering diet-related health biomarkers.

Methods
In a 12-week randomised controlled trial, 107 women and 29 men were assigned into three diet groups (ANIMAL, 50/50, PLANT) with animal-to-plant-protein ratios of 70/30, 50/50, and 30/70, respectively. Life-cycle-assessment-based coefficients for foods were used to assess the climate impact of the diet groups, based on four-day food records. Correlations between climate impact and biomarkers were assessed.

Results
The climate impact (CO2 eq.) for PLANT was 3.32 kg per day, 3.05 kg per 2,000 kcal, and 0.04 kg per gram of protein, for 50/50 4.34, 4.20, and 0.05 kg, and for ANIMAL 4.93, 4.94, and 0.06 kg, respectively (p < 0.05 for all except ANIMAL vs. 50/50 /g protein and /2,000 kcal). Climate impact correlated weakly positively with colorectal cancer risk markers and a positive status of bone turnover, but not with cardiometabolic risk markers. Animal-based iron intake and climate impact (per 2,000 kcal) had a strong positive correlation 0.70 C.I. [0.60, 0.77], while saturated fat (0.29 [0.13, 0.44]) and calcium (0.37, [0.22, 0.51]) intake had a weak positive correlation, and fibre intake (− 0.37, [− 0.51, − 0.21]) a weak negative correlation with climate impact.

Conclusion
Replacing animal-sourced proteins with plant-sourced proteins reduced the climate impact of the diet. The relationship between climate impact and biomarkers was more ambiguous indicated by both beneficial and harmful indicators within lower climate impacts.

Clinical trial registry
NCT03206827; registration date: 2017–06–30.
Numerical modeling of fluid displacement in Hele-Shaw cells: a gap-averaged approach for power-law and Newtonian fluids
Authors: Zhang Yao , Giljarhus Knut Erik Teigen , Skadsem Hans Joakim , Barrouillet Benjamin 
Published: February 2025

Abstract
This work presents a physics-based two-dimensional model for simulating displacement flows of power-law fluids in Hele-Shaw cells. The model is derived by approximating fully developed velocity profiles across the gap-wise direction and averaging the mass and momentum conservation equations, resulting in a two-dimensional formulation that efficiently captures complex fluid dynamics. Implemented in OpenFOAM, this approach achieves computational speeds over 200 times faster than comparable 3D simulations, while preserving the accuracy of displacement dynamics. Validated against 3D DNS results and experimental data, this 2D model accurately replicates observed flow phenomena. Simulations of over 70 cases examined the effect of the ratio of friction pressure gradients (RFG) between fluid pairs on interface stability. Results show that RFGs below unity maintain a flat interface, while higher values induce viscous fingering. In cases with RFG closer to unity, a longer duct or extended displacement time is required for significant finger growth.
The SAPIENS 3D-printed temporal bone model: a real tool for advanced otologic surgery education
Authors: Iannella Giannicola , Pace Annalisa , Greco Antonio , De Virgilio Armando , Bellizzi Mario Giuseppe , Croce Enrica , Lechien Jerome R. , Maniaci Antonino , Cocuzza Salvatore , Gioacchini Federico , Re Massimo , Collettini Andrea , Gatti Lodovica , Perrone Tiziano , Simon François , Gargula Stéphane , Magliulo Giuseppe 
Published: February 2025

Abstract

Objective
Our study focused on the development and evaluation of the SAPIENS (Specific Anatomical Printed-3D-model In Education and New Surgical Simulations) as a valid tool for otologic surgical education.

Methods
Twenty junior otolaryngologist surgeons in training were enrolled in the study. Each participant was invited to perform dissection of three different temporal bones. 1)Transparent 3-D printed model; 2)Opaque 3-D model; 3)fresh frozen human temporal bone. Following their drilling experience, participants answered to two specific questionnaires. The first was a questionnaire developed by Mowry et al. to evaluate 3D models in its general characteristics of anatomy and dissection, while the second one was a questionnaire specifically designed to compare the 3-D printed models with the human fresh frozen temporal bone.

Results
The average total score of the questionnaire was calculated as 53.2/61 in transparent 3-D model and 55.4/61 in the opaque 3-D model. These values indicate that the 3D printed models closely resemble the human TB in terms of anatomy and dissection. Comparisons of the 3D model and human TB were rated as very similar in all surgical steps. The total score was 4/5 in the transparent 3-D model and 4.2/5 in the opaque 3-D model.

Conclusion
We have designed and developed a 3D-printed model of the temporal bone that closely resembles the human temporal bone. The SAPIENS 3-D printed temporal bone model could be considered a valuable tool for advancing oto-surgical education due to its similarity to the human temporal bone in terms of anatomy and dissection.
Optimizing the placement of distributed energy storage and improving distribution power system reliability via genetic algorithms and strategic load curtailment
Authors: Islam Anfaj , Rudra Souman , Kolhe Mohan Lal 
Published: February 2025

Abstract
As the integration of distributed generation (DG) and smart grid technologies grows, the need for enhanced reliability and efficiency in power systems becomes increasingly paramount. Energy storage systems (ESS) play a crucial role in achieving these objectives, particularly in enabling effective islanding operations during emergencies. This research leverages genetic algorithms to identify optimal combinations of ESS units and strategic load curtailment techniques to mitigate potential contingencies. The results demonstrate that integrating ESS significantly improves network reliability, optimizes infrastructure utilization, and is particularly beneficial in regions with high commercial and industrial load percentages. Moreover, the study underscores the critical role of load shedding in balancing reliability improvements and the sizing of DG units, offering valuable insights for future energy management approaches. By employing binary load curtailment strategies, the research determines the optimal location and size of ESS and DG units within the distribution network. The analysis reveals that ESS integration leads to a reduction in net annual costs while providing valuable insights into network reliability through the assessment of expected energy not supplied. Two case studies comparing various storage technologies with a base case without ESS highlight the cost-effectiveness of enhancing system reliability through distributed storage allocation. The study also emphasizes the significance of load shedding in balancing reliability enhancement and DG sizing, examining the effects of DG placement across different network buses. Finally, this article investigates the impact of diverse load mixes, indicating the need for larger ESS units as the proportion of commercial and industrial loads increases, accompanied by rising costs. Through these comprehensive analyses, the study offers valuable insights into optimizing the placement of distributed storage units and improving the reliability of distribution systems.
Assessment of Groundwater Depressurisation due to Mining Considering Flow Nonlinearity in Connected Fractures
Authors: Chen Mingwei , Zhang Chengguo , Canbulat Ismet , Saydam Serkan 
Published: February 2025

Abstract
Longwall mining is a productive method for underground coal resource recovery, but usually leads to extensive fracture networks that facilitate groundwater drainage into mined-out areas. Accurately assessing the coverage and magnitude of induced groundwater depressurisation is crucial for sustainable mining practices, but is often constrained by simplified representations of fracture flow. This paper investigates the nonlinear flow behaviour in connected fractures and develops a governing equation applicable to field-scale models for improved groundwater impact assessments. Laboratory tests on intersected pathways demonstrate that inflows interact and redirect along curved paths with localised turbulence. Numerical upscaling reveals a negative correlation between pressure drop and pathway geometry, identifying the laminar flow threshold as Reynolds numbers (

$$Re$$

Re

) ≤ 10. A modified cubic law (MCL) is derived from the best-fit linear relationship between hydraulic gradient and flow rate, defining a super-cubic correlation where the exponent increases asymptotically from 3.15 to 3.77 with apertures. Applying the MCL equation to a field-scale model reveals that the depressurised zone has a height of 0.86 times the panel width, aligning with the upper limit of horizontal stress relief and the significant outflow horizon measured by borehole acoustic scanning. The depressurisation remains confined below the claystone unit, which is interpreted as being associated with clay swelling upon water absorption. Comparisons with empirical equations suggest that integrating fluid flow analysis into numerical simulations allows more direct and comprehensive assessments for groundwater and sustainable purposes. The paper improves the understanding of flow nonlinearity in connected fractures and offers a practical numerical method for evaluating the hydrogeological impacts of mining activities.
Local and non-local chemical potential and hardness: a grand canonical ensemble approach
Authors: Zerón Paulino , Pantoja-Hernández Maurizio A. , Franco-Pérez Marco , Gázquez José L. 
Published: February 2025

Abstract

Context
The formulation of conceptual density functional theory in the grand canonical ensemble provides a theoretical framework that allows one to establish additional insights about the response functions that characterize this approach. In particular, through this procedure, one can establish the local counterpart of the chemical potential which, when integrated over all the space, leads to the global quantity and the local counterpart of the hardness that not only provides a function free of ambiguities, but also generates through its integration over all the space the well-defined value of the global quantity given by the difference of the vertical first ionization potential and electron affinity. In the present work, the non-local counterpart of these local reactivity descriptors is derived making use of the Fukui kernel descriptor previously developed by us. Then, the local and non-local chemical potential and hardness, thus obtained, are applied to study site and bond reactivities of several systems, to rationalize the behavior of kinetic and thermodynamic properties, through the chemical information that these indexes provide.

Methods
The electronic structure calculations required to evaluate the reactivity indexes analyzed in this work were done with the PBE0 exchange–correlation energy functional. The geometry optimization was done in all cases in a modified version of the NWChem program, while the Hirshfeld population analysis was done in a modified version of the demon2k program. For the electrophilic addition of hydrogen halides (HX) to several substituted ethenes and the hydration reaction of aldehydes and ketones, the 6-311G** basis set was used, while for the bond enthalpies of chemical reactions where there is a homolytic bond break and the trans influence in which the lability of the leaving ligand is modified by the ligand opposite to it, the Def2-TZVP was used.
WEFT: a consistent and tamper-proof methodology for acquisition of automatically verifiable forensic web evidence
Authors: Cantelli-Forti Alessandro , Longo Giacomo , Lupia Francesco , Russo Enrico 
Published: February 2025

Abstract
The pervasiveness of web-based services has further complicated forensic operations, as traditional acquisition techniques do not fit with the volatile nature of online evidence. The current best practice often suffer from procedural shortcomings and are prone to tampering, which can lead to the dismissal of evidence in legal contexts. This paper introduces an acquisition methodology aimed at improving the integrity and admissibility of digital evidence acquired from live web environments. Our proposed approach addresses these issues and adheres to the requirement of international standards by establishing a unified format as a single source of truth, secure timestamping, and enabling automatic verification of integrity and its content, thereby offering more transparency to the involved parties. An extensive evaluation with live acquisition of the top 100 most popular websites indicates that the methodology produces an artifact comparable to state-of-the-art tools with added benefits.
Do deep regional trade agreements facilitate regional production networks in Latin American and Caribbean countries?
Authors: Murakami Yoshimichi 
Published: February 2025

Abstract
Applying a generalized event study design to a structural gravity model, this study analyzes the dynamic effects of the depth of regional trade agreements (RTAs)—measured by the coverage and legal enforceability of World Trade Organization (WTO)-plus and WTO-extra policy areas—on production network trade in all 33 Latin American and Caribbean (LAC) countries from 1986 to 2015. It constructs a unique dataset on the indexes of depth, breadth, and core depth of all RTAs in force involving at least two LAC countries, using a World Bank database on RTA content. The results indicate that the depth and breadth of RTAs positively affect intra-regional parts and components exports in the LAC region. Moreover, no differential trends exist prior to RTA signature, supporting the causal interpretation of the results. However, the effects are substantially heterogeneous by the type of agreements and characteristics of country pairs. The depth and breadth consistently show positive effects 2 years after the enforcement for the customs union among Latin American countries (the Southern Common Market, MERCOSUR), and plurilateral free trade agreements (FTAs) in the LAC countries. Conversely, the depth and breadth show immediate negative effects for plurilateral FTAs with developed countries outside the region (e.g., the United States or European countries). Furthermore, the depth of RTAs has particularly significant effects on parts and components exports compared to other trade categories, such as primary goods exports.
Asymmetric shock persistence in the OECD Stock Exchanges: New Insight from Quantile Exponential Smooth Transition Autoregression Approach
Authors: Özdemir Müge 
Published: February 2025

Abstract
This study offers novel empirical insights into the asymmetric persistence of shocks in OECD stock markets over the period 1994–2023, employing a nonlinear quantile autoregression framework built on the Quantile Exponential Smooth Transition Autoregression (QESTAR) method. By capturing the complexities of market responses to both the direction and magnitude of shocks, as well as asymmetric adjustment speeds under varying long-term conditions, our findings highlight significant dynamics. Shock persistence is most pronounced in the lower quantiles, reflecting non-stationarity in response to smaller shocks, while upper quantiles display faster mean reversion to larger shocks, indicating distinct market adjustments across quantiles. The nonparametric quantile autoregressive model outperforms its linear counterpart, proving more effective in capturing the asymmetric and nonlinear dynamics inherent in asset pricing. These findings hold critical implications for market efficiency and predictability, shedding light on the pivotal role of shock asymmetry in shaping international market behavior. Moreover, the study establishes a robust foundation for future research on momentum portfolio strategies, emphasizing the value of quantile-based models in refining asset management approaches under asymmetric market conditions.