bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid business models in the sharing economy: The role of business model design for managing the environmental paradox
Authors: Reuter Emmanuelle 
Published: November 2021

AbstractWith the primary emphasis on the tensions that platform organizations face between both for‐profit and environmental value‐creation goals, we know very little about the managerial drivers and mechanisms through which they realize multiple goals. Based on a qualitative, inductive case study of a UK‐based digital platform's business model, we uncover the role of business model design. We find that the emphasis managers put on either the redistribution or the accessibility design theme shapes the environmental and financial value‐creation, respectively and that a hybrid business model (i.e., realizing both for‐profit and for‐purpose value‐creation) hinges on their integration. Two managerial drivers—strategic synergies and dynamic coupling—enable platform organizations to increase integration. We contribute to the literatures on hybrid business models, paradox, and business models for sustainability, suggesting that digital platforms not only create, but can actively manage the environmental paradox by integrating multiple design themes within hybrid business models.
Nickel Salicylideniminato 1D MOFs via Electrochemical Polymerization
Authors: Lukyanov Daniil A. , Vereshchagin Anatoliy A. , Beletskii Evgenii V. , Atangulov Arslan B. , Yankin Andrei N. , Sizov Vladimir V. , Levin Oleg V. 
Published: November 2021

AbstractPolymers derived from nickel complexes of salicylaldimines are extensively studied due to their electrochemical, catalytic, and sensing properties. However, almost all studies are devoted to the polymers obtained from tetradentate bis(salicylidenaldiminato) complexes, in which the aromatic rings are bound via an imine bridge. Herein, we report a first systematic study focused on the polymerization of salicylaldimine nickel complexes without a bridge between the imine fragments. As a result, an impact of the ligand structure on the polymerization ability of the complexes and electrochemical behavior of the polymers obtained thereof was discovered and quantified. An observed phenomenon was rationalized both computationally and experimentally, involving the electrochemical and spectroelectrochemical techniques.
Influence of geometric parameters on partial compressive force and pushing performance of flow diverter
Authors: Qiu Xiaojian , Gu Xuelian , Liu Chenyang , Tian Hao , Chen Ruina , Li Yuanyuan 
Published: November 2021

AbstractResearch on flow diverter (FD) has progressed over the past decades; however, the relationships between parameters such as stent diameter, porosity, and number of wires and the properties of FDs, such as partial compressive force and push resistance, are not well understood. In this study, the partial compressive force and push resistance of braided FDs with varying porosity (61%–75%), diameter (2.5–5.0 mm), and number of wires (48 or 64) were evaluated using finite element analysis (FEA) and bench tests. At a small compression ratio, the 48‐wire stents exhibited a larger partial compressive force than 64‐wire stents of the same diameter. But when the compression ratio was 50%, the 64‐wire stents had better resistance to pressure. The partial compressive force decreased as the stent diameter increased when all other parameters were equal. However, the influence of the diameter decreased as the stent porosity increased. The push resistance decreased as the porosity and diameter increased, and increased with the number of wires. These results provide useful information for FD design. Decreasing the number of wires can reduce the push resistance, while the push resistance is mainly influenced by the porosity and number of wires, and almost has no relationship with the partial compressive force. The FEA model proved very reliable, and corresponded well to the bench test results, which indicates that this model can be utilized to guide the design of FDs.
Amino‐Linked Conjugated Tetrazole Ring Passivation Strategy for Air‐Processed Perovskite Cells with Predominant Stability and Efficiency
Authors: Deng Yaxin , Zhang Hongxia , Li Xin , Wang Rui 
Published: November 2021

AbstractPerovskite solar cells (PSCs) develop rapidly with certified efficiency over 25.5 %, but there are remaining problems such as defects‐induced recombination and degradation throughout the whole device. Functional organic small molecule passivation strategies are diverse and efficient, enhancing the efficiency and stability of PSCs. Here, 5‐aminotetrazole (5ATZ) was introduced for the first time as an effective passivator, where −NH2 and −NH as active sites interacted with the Pb and I related to vacancy defects in perovskites, anchoring defects and preventing further unavoidable ion migration and device degradation. Furthermore, the extensive π‐electron delocalization around the tetrazole conjugated ring significantly promoted the charge transfer. Therefore, the 5ATZ‐processed PSCs provided enhanced voltage and current, showed superior 19.75 % power conversion efficiency with excellent performance and improved stability, and demonstrated one of the best performances in all‐air preparation to date. The simultaneous multi‐effect passivation strategy of vacancy defects in perovskites will contribute to eliminate obstacles on the road to commercialization of PSCs.
Synergistic Effects of Surface Coating and Bulk Doping in Ni‐Rich Lithium Nickel Cobalt Manganese Oxide Cathode Materials for High‐Energy Lithium Ion Batteries
Authors: Reissig Friederike , Lange Martin Alexander , Haneke Lukas , Placke Tobias , Zeier Wolfgang G. , Winter Martin , Schmuch Richard , Gomez‐Martin Aurora 
Published: November 2021

AbstractNi‐rich layered oxide cathodes are promising candidates to satisfy the increasing energy demand of lithium‐ion batteries for automotive applications. Thermal and cycling stability issues originating from increasing Ni contents are addressed by mitigation strategies such as elemental bulk substitution (“doping”) and surface coating. Although both approaches separately benefit the cycling stability, there are only few reports investigating the combination of two of such approaches. Herein, the combination of Zr as common dopant in commercial materials with effective Li2WO4 and WO3 coatings was investigated with special focus on the impact of different material processing conditions on structural parameters and electrochemical performance in nickel‐cobalt‐manganese (NCM) || graphite cells. Results indicated that the Zr4+ dopant diffusing to the surface during annealing improved the electrochemical performance compared to samples without additional coatings. This work emphasizes the importance to not only investigate the effect of individual dopants or coatings but also the influences between both.
Prior night sleep moderates the daily spillover between conflict with peers and family and diurnal cortisol
Authors: Armstrong‐Carter Emma , Nelson Benjamin W. , Telzer Eva H. 
Published: November 2021

AbstractWe investigated whether daily experiences of conflict with family and peers were associated with fluctuations in diurnal cortisol, and whether sleep buffers the associations between conflict and diurnal cortisol. A racially diverse sample of 370 adolescents (ages 11–18; 57.3% female) provided daily diaries for 5 days and saliva samples for 4 days. Hierarchical linear models tested how peer and family conflict were associated with diurnal cortisol (i.e., total cortisol output, cortisol slope, and cortisol awakening response) the next day, and whether these associations were moderated by sleep duration the previous night. When adolescents experienced peer conflict, they showed higher area under the curve (AUC) the next day if they had slept less the night prior to conflict, but relatively lower cortisol awakening response (CAR) and flatter cortisol slope the next day if they had slept more the night prior to conflict. When adolescents experienced family conflict, they also showed higher AUC the next day if they had slept less the night prior to conflict, but higher CAR the next day if they had slept more the night prior to conflict. Family conflict and sleep were not directly or interactively related to cortisol slope.
Atrial appendage closure in patients with heart failure and atrial fibrillation: industry‐independent single‐centre study
Authors: Saad Mohammed , Osman Mohamed , Hasan‐Ali Hosam , Abdel Ghany Mohammed , A Alsherif Mohamad , Risha Osama , Sano Makoto , Fink Thomas , Heeger Christian‐Hendrik , Vogler Julia , Sciacca Vanessa , Eitel Charlotte , Stiermaier Thomas , Joost Alexander , Keelani Ahmad , Fuernau Georg , Saraei Roza , Kuck Karl‐Heinz , Eitel Ingo , Tilz Roland Richard 
Published: November 2021

AbstractAimsTo evaluate outcomes of percutaneous left atrial appendage closure (LAAC) in patients with congestive heart failure (CHF) and non‐valvular atrial fibrillation (AF) in a consecutive, industry‐independent registry associated with periprocedural success and complications during long‐term follow‐up.Methods and resultsFor this analysis, we included patients who underwent transcatheter LAAC from January 2014 to December 2019 at the University Heart Center in Lübeck, Germany, and compared patients with presence of CHF defined as patients with a reduced left ventricular ejection fraction (LVEF ≤ 40%), patients with a mid‐range LVEF (LVEF 41–49%), patients with diastolic dysfunction and preserved LVEF (LVEF ≥ 50%), and patients with right‐sided heart failure and impaired right ventricular function (tricuspid annular plane systolic excursion < 17) to patients undergoing LAAC with no CHF. Primary endpoints were defined as periprocedural complications, and complications during long‐term follow‐up presented as major adverse cardiac and cerebrovascular events (MACCE). A total of 300 consecutive patients underwent LAAC. Of these, 96 patients in the CHF group were compared with 204 patients in the non‐CHF group. Implantation success was lower in CHF group in comparison with non‐CHF group (99.5% vs. 96%, P = 0.038); otherwise, there were no differences in periprocedural complications between groups. Patients with CHF showed a significantly higher incidence of MACCE rate (31.9% vs. 15.1%, P = 0.002) and more deaths (24.2% vs. 7%, P ≤ 0.001) during long‐term follow‐up. In Cox multivariable regression analysis, CHF was an independent predictor of mortality after LAAC implantation at long‐term follow‐up (hazard ratio 3.23, 95% confidence intervals 1.52–6.86, P = 0.002).ConclusionsImplantation of LAAC devices in patients with non‐valvular AF and CHF is safe. The increased mortality in patients with CHF compared with patients without CHF during the long‐term follow‐up is mainly attributed to comorbidities associated with CHF.
DoE‐based validation of a HPLC–UV method for quantification of rotigotine nanocrystals: Application to in vitro dissolution and ex vivo nasal permeation studies
Authors: Saha Paramita , Pandey Murali Monohar 
Published: November 2021

AbstractThe current work is focused on optimization, development, and validation of a sensitive and specific reversed‐phase high‐performance liquid chromatography (RP‐HPLC) method for the estimation of rotigotine (RTG) in bulk and nanoformulations. The RP‐HPLC method was effectively optimized using the concepts of design of experiments. Critical method variables (CMVs) were screened using Plackett–Burman design. Box–Behnken, a surface response methodology‐based design, was further used for the optimization of CMVs with the number of theoretical plates and retention time (min) as responses. The optimized chromatographic conditions for the RP‐HPLC method were: acetonitrile proportion: 54% v/v, pH of buffer: 5.0 (10 mM), and flow rate: 0.65 mL/min. The number of theoretical plates and retention time in the study were found to be 11206 and 7.65 min, respectively. The developed method exhibited good linearity (R2 = 0.9995) within a range of 25–600 ng/mL and LOD and LOQ were found to be 9 and 12 ng/mL, respectively. The developed RP‐HPLC method was found sensitive, accurate, precise, specific, robust, and stability indicating according to the regulatory guidelines. The validated method was efficiently applied for in vitro dissolution study, ex vivo nasal permeation study, and estimation of drug content of RTG nanocrystals.
2‐deoxyglucose and β‐hydroxybutyrate fail to attenuate seizures in the betamethasone‐NMDA model of infantile spasms
Authors: Janicot Remi , Shao Li‐Rong , Stafstrom Carl E. 
Published: November 2021

AbstractInfantile spasms (IS) is an epileptic encephalopathy with a poor neurodevelopmental prognosis, and limited, often ineffective treatment options. The effectiveness of metabolic approaches to seizure control is being increasingly shown in a wide variety of epilepsies. This study investigates the efficacy of the glycolysis inhibitor 2‐deoxyglucose (2‐DG) and the ketone body β‐hydroxybutyrate (BHB) in the betamethasone‐NMDA model of rat IS. Prenatal rats were exposed to betamethasone on gestational day 15 (G15) and NMDA on postnatal day 15 (P15). Video‐electroencephalography (v‐EEG) was used to monitor spasms. NMDA consistently induced hyperflexion spasms associated with interictal sharp‐slow wave EEG activity and ictal flattening of EEG signals, reminiscent of hypsarrhythmia and electrodecrement, respectively. 2‐DG (500 mg/kg, i.p), BHB (200 mg/kg, i.p.), or both were administered immediately after occurrence of the first spasm. No experimental treatment altered significantly the number, severity, or progression of spasms compared with saline treatment. These data suggest that metabolic inhibition of glycolysis or ketogenesis does not reduce infantile spasms in the NMDA model. The study further validates the betamethasone‐NMDA model in terms of its behavioral and electrographic resemblance to human IS and supports its use for preclinical drug screening.
Unveiling whole‐brain dynamics in normal aging through Hidden Markov Models
Authors: Moretto Manuela , Silvestri Erica , Zangrossi Andrea , Corbetta Maurizio , Bertoldo Alessandra 
Published: November 2021

AbstractDuring normal aging, the brain undergoes structural and functional changes. Many studies applied static functional connectivity (FC) analysis on resting state functional magnetic resonance imaging (rs‐fMRI) data showing a link between aging and the increase of between‐networks connectivity. However, it has been demonstrated that FC is not static but varies over time. By employing the dynamic data‐driven approach of Hidden Markov Models, this study aims to investigate how aging is related to specific characteristics of dynamic brain states. Rs‐fMRI data of 88 subjects, equally distributed in young and old were analyzed. The best model resulted to be with six states, which we characterized not only in terms of FC and mean BOLD activation, but also uncertainty of the estimates. We found two states were mostly occupied by young subjects, whereas three other states by old subjects. A graph‐based analysis revealed a decrease in strength with the increase of age, and an overall more integrated topology of states occupied by old subjects. Indeed, while young subjects tend to cycle in a loop of states characterized by a high segregation of the networks, old subjects' loops feature high integration, with a crucial intermediary role played by the dorsal attention network. These results suggest that the employed mathematical approach captures the complex and rich brain's dynamics underpinning the aging process.
Impact of the Corona Virus Disease 2019 Pandemic on Hepatology Practice and Provider Burnout
Authors: Russo Mark W. , Kwok Ryan , Serper Marina , Ufere Nneka , Hameed Bilal , Chu Jaime , Goacher Elizabeth , Lingerfelt John , Terrault Norah , Reddy K. Rajender 
Published: November 2021

The corona virus disease 2019 (COVID‐19) pandemic has had a wide‐ranging impact on the clinical practice of medicine and emotional well‐being of providers. Our aim was to determine the impact of the COVID‐19 pandemic on practice and burnout among hepatology providers. From February to March 2021, we conducted an electronic survey of American Association for the Study of Liver Diseases (AASLD) members who were hepatologists, gastroenterologists, and advanced practice providers (APPs). The survey included 26 questions on clinical practice and emotional well‐being derived from validated instruments. A total of 230 eligible members completed the survey as follows: 107 (47%) were adult transplant hepatologists, 43 (19%) were adult general hepatologists, 14 (6%) were adult gastroenterologists, 11 (5%) were pediatric hepatologists, 45 (19%) were APPs, and 9 (4%) were other providers. We found that 69 (30%) experienced a reduction in compensation, 92 (40%) experienced a reduction in staff, and 9 (4%) closed their practice; 100 (43%) respondents reported experiencing burnout. In univariate analysis, burnout was more frequently reported in those ≤55 years old (odds ratio [OR], 2.2; 95% confidence interval [CI], 1.2‐4.2), women (OR, 2.2; 95% CI, 1.3‐3.7), nontransplant hepatology (OR, 2.0; 95% CI, 1.1‐3.3), APPs (OR, 2.7; 95% CI, 1.4‐5.1), and those less than 10 years in practice (OR, 1.9; 95% CI, 1.1‐3.3). In multivariable analysis, only age ≤55 years was associated with burnout (OR, 2.3; 95% CI, 1.1‐4.8). The most common ways the respondents suggested the AASLD could help was through virtual platforms for networking, mentoring, and coping with the changes in practice due to the COVID‐19 pandemic. Conclusion: The COVID‐19 pandemic has had a substantial impact on the clinical practice of hepatology as well as burnout and emotional well‐being. Women, APPs, and early and mid‐career clinicians more frequently reported burnout. Identified strategies to cope with burnout include virtual platforms to facilitate networking and mentoring.
Expression and existence forms of mast cell activating molecules and their antibodies in systemic lupus erythematosus
Authors: Wang Yuping , Wang Tengkai , Cai Meijuan , Zhu Shuzhen , Song Lijun , Wang Qian 
Published: November 2021

AbstractIntroductionMast cells are regarded as a kind of classical anaphylaxis cells. However autoimmune diseases and allergic reactions have many similarities or overlaps. A large number of papers have proved that mast cells play a significant role in the pathogenesis of systemic lupus erythematosus (SLE). It is speculated that IgE, anti‐IgE antibodies, FcεRI, and anti‐FcεRI antibodies activate mast cells through autoimmune pathways and participate in the disease process of SLE. Naturally occurring protein molecules not only exist in monomer form, but also in polymer of protein molecules. Therefore, whether IgE, FcεRIα, anti‐IgE antibodies, and anti‐FcεRI antibodies also exist in polymeric forms in the natural state is worthy of further investigation.MethodsThe serum samples and clinical data of 131 patients with SLE were collected from Qilu Hospital (Qingdao). Sixty healthy individuals were collected as the control group. Serum FcεRIα, anti‐IgE, and anti‐FcεRI were detected by enzyme‐linked immunosorbent assay. Serum IgE was detected by rate scatter nephelometry. A Chinese hamster ovarian cancer cell line CHO3D10 transfected with human FcεRIα was cultured and the cell protein extract was prepared. The existence forms of FcεRIα in the cell protein extract were detected by the native‐page method.ResultsThe serum FcεRIα in SLE patients was significantly higher than that in control group (3.52 [2.18, 4.71] µg/ml and 1.87 [1.52, 2.33] µg/ml, respectively; p < .05). Anti‐IgE was significantly lower than that in the control group (0.85 [0.55, 1.21] µg/ml and 1.23 [0.95, 1.58] µg/ml, respectively; p < .05). The CHO3D10 cell line expressed the FcεRIα, which had one kind of monomer (mFcεRIα) and two kinds of polymers (pFcεRIα) in the degeneration conditions.ConclusionIn patients with SLE, the expression of FcεRIα was increased and the level of anti‐IgE was decreased. FcεRIα had one kind of monomer and two kinds of polymers. Mast cell‐associated FcεRIα involved in the inflammatory lesion of SLE.
Mouse Digit Tip Regeneration Is Mechanical Load Dependent
Authors: Dolan Connor P , Imholt Felisha , Yang Tae-Jung , Bokhari Rihana , Gregory Joshua , Yan Mingquan , Qureshi Osama , Zimmel Katherine , Sherman Kirby M , Falck Alyssa , Yu Ling , Leininger Eric , Brunauer Regina , Suva Larry J , Gaddy Dana , Dawson Lindsay A , Muneoka Ken 
Published: November 2021

ABSTRACT
Amputation of the mouse digit tip results in blastema-mediated regeneration. In this model, new bone regenerates de novo to lengthen the amputated stump bone, resulting in a functional replacement of the terminal phalangeal element along with associated non-skeletal tissues. Physiological examples of bone repair, such as distraction osteogenesis and fracture repair, are well known to require mechanical loading. However, the role of mechanical loading during mammalian digit tip regeneration is unknown. In this study, we demonstrate that reducing mechanical loading inhibits blastema formation by attenuating bone resorption and wound closure, resulting in the complete inhibition of digit regeneration. Mechanical unloading effects on wound healing and regeneration are completely reversible when mechanical loading is restored. Mechanical unloading after blastema formation results in a reduced rate of de novo bone formation, demonstrating mechanical load dependence of the bone regenerative response. Moreover, enhancing the wound-healing response of mechanically unloaded digits with the cyanoacrylate tissue adhesive Dermabond improves wound closure and partially rescues digit tip regeneration. Taken together, these results demonstrate that mammalian digit tip regeneration is mechanical load-dependent. Given that human fingertip regeneration shares many characteristics with the mouse digit tip, these results identify mechanical load as a previously unappreciated requirement for de novo bone regeneration in humans. © 2021 American Society for Bone and Mineral Research (ASBMR).