bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Autopsy Results in Patients with Liver Cirrhosis over 2015-2018
Authors: Mitsura V. M. , Skuratov A. G. , Savarina V. A. , Tereshkov D. V. , Poddubny A. A. 
Published: November 2021

Objective: to analyze the mortality structure of patients with liver cirrhosis over 2015-2018 in Gomel.Material and methods. A retrospective cohort analysis of 130 findings of postmortem autopsy of patients with liver cirrhosis has been performed (data of the departments of Gomel Regional Pathology Bureau at Gomel Regional Infectious Clinical Hospital, Gomel City Clinical Hospital No. 3 and Gomel City Clinical Hospital No. 2, 2015-2018). The age and gender structure of the patients, etiology and cause of death were analyzed. The data were entered and analyzed in MS Excel, 2010.Results. Most frequently, the patients with cirrhosis die at 50-59 and usually of hepatorenal syndrome (HRS), gastrointestinal bleeding, and acute posthemorrhagic anemia. Non-viral hepatitis as a cause of cirrhosis is more prevalent (61.5 %) than viral hepatitis, while the etiology for more than a third of the cirrhosis cases (38.5 %) is not determined. Most of the patients who died were of the working age (67.7 %) and mainly males (56.2 %). More than a third of the patients (38.5 %) had been dependent on alcohol, while only 11.5 % patients had been dia nosed with alcohol related cirrhosis.Conclusion. Thus, liver cirrhosis is still a socially topical issue for young ablebodied people. There remains a tendency to underestimate the alcoholic etiology of cirrhosis, as well as the uncertainty of the etiology of a significant part of detected cirrhosis cases.
Role of Psychoemotional Disorders in Pregnant Women in the Development of a Prolonged Second Period of Labor
Authors: Kalachev V. N. , Zakharenkova T. N. 
Published: November 2021

Objective: to assess the value of the psychoemotional state of pregnant women in the development of a prolonged second period of labor.Material and methods. 76 pregnant women were examined. In 26 women, childbirth was complicated by a prolonged second period of labor, and they constituted the main group. The control group included 50 women who had physiologic birth. The psychoemotional state was analyzed using the Spielberg test and the test of a pregnant woman's attitudes.Results. There were some differences between the groups in terms of the tendency in the levels of personal anxiety and occurrence of high situational anxiety. The Spielberg test has revealed more «positive» affirmative answers than «negative» ones. 46.1 % women in the main group do not «feel a sense of inner satisfaction», which is statistically significantly higher than in the control group - 24.0 % (p = 0.04). In the main group, in contrast to the control group, the women are more often not «worried about possible failures». During the study of the types of the psychological component of the gestational dominant, mixed types were mainly observed, and the distribution in the groups did not have statistically significant differences. The women with a prolonged second period of labor had a tendency to form the predominantly euphoric type of the psychological component of the gestational dominant.Conclusion. During pregnancy, the patients with a prolonged second period formed a coping strategy in the form of a predominantly euphoric attitude to pregnancy associated with elevated situational anxiety.
Reactions of Subcutaneous Cellular Tissue in Response to the Implantation of a Polypropylene Endoprosthesis Modified with a Polycaprolactone Solution by Electrospinning
Authors: Bereschenko V. V. , Nadyrov E. A. , Lyzikov A. N. , Petrenyov D. R. , Kondrachuk A. N. 
Published: November 2021

Objective: to study the morphological features of subcutaneous tissue in response to the implantation of a polypropylene mesh endoprosthesis (PSE) modified with a polycaprolactone solution by the method of electrospinning. Material and methods. The object of the study was modified polypropylene mesh endoprostheses implanted in experimental animals. The animals were removed from the experiment on the 3rd, 7th, 60th day of the experiment. Subcutaneous fatty tissue along with the implanted material and regional lymph nodes were fixed in a 10 % solution of neutral formalin, followed by histological posting according to the standard technique and filled with paraffin. Histological sections 3-4 μm thick were stained with hematoxylin and eosin. The morphological assessment of reactions to the implantation of the materials was carried out by means of the calculation of the cellular elements of inflammatory and connective tissue origin along the periphery of the implants (neutrophilic leukocytes, phagocytic neutrophilic leukocytes, degenerating neutrophilic leukocytes, eosinophilic leukocytes, lymphocytes, plasmacytes, histiocytes, macrophages, fibrocytes, fibroblasts, multinucleated giant cells).Results. The study of the cellular composition has showed a statistically significant increase in the content of fibrocytes (p = 0.002) and fibroblasts (p < 0.001) on the 7th day of observation around the modified PSE. On the 60th day, the number of neutrophilic leukocytes at the periphery of the modified PSE was lower than that of the control sample (p = 0.004). The enhancement of the fibroplastic properties of the samples modified with polycaprolactone by electrospinning was characterized by a less pronounced inflammatory reaction of the peripheral tissues.Conclusion. The obtained data are indicative of the fact that the modification of PSE with polycaprolactone reduces the reactive properties of endoprostheses and make it possible to recommend to introduce this method of PSE modification in clinical practice.
Features of the Organism`s Adaptation of Female Obstetrician-Gynecologists to the Existing Working Conditions
Authors: Lisok E. S. , Naumov I. A. 
Published: November 2021

Objective: to establish the features of the organism`s adaptation of female obstetrician-gynecologists to the existing working conditions .Material and methods. The features of the organism`s adaptation of female obstetrician-gynecologists (main group, n = 64) of in-patient and maternity welfare clinics, therapists of local territorial out-patient clinics (comparison group, n = 31), as well as female employees of health organizations with higher education not providing medical care (control group, n = 31) to the existing working conditions were evaluated on the basis of sociological, hygienic, and statistical research methods.Results. The obstetrician-gynecologists worked in harmful working conditions: class 3.3. - in the in-patient hospitals and class 3.2. - in the out-patient clinics. Almost half of the examined female obstetrician-gynecologists revealed decreased adaptive reserves of the organism, whose degree of manifestation was reliably different from the women of the control group (p ˂ 0.05).Conclusion. The harmful working conditions at the workplaces of female obstetrician-gynecologists lead to the breakdown of the organism`s adaptive mechanisms and create a professional risk for the subsequent development of a wide range of somatic pathologies.
Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma in the Practice of the General Practitioner
Authors: Kozich Zh. M. , Smirnova L. A. , Martinkov V. N. 
Published: November 2021

Multiple myeloma is an incurable malignancy of hematopoietic tissue characterized by lesions of the bone marrow, presence of multiple destructive processes within bone tissue, kidney damage, and infectious complications. Up to 60 % cases of newly diagnosed multiple myeloma debut from monoclonal gammopathy.Monoclonal gammopathies are a large group of diseases whose distinctive feature is the secretion of pathologic immunoglobulins called monoclonal proteins (synthesized in abundant quantities immunoglobulins of one class or/and type whose chemical structure, molecular mass, and immunological features have been changed). Most often monoclonal protein is a biomarker of clonal cell proliferation. Besides plasma cell tumors paraprotein secretion is often common for other lymphoproliferative diseases, some kidney diseases, systemic diseases of connective tissue, primary amyloidosis, solid tumors, liver lesions, sarcoidosis, Gaucher disease, Sjogren syndrome, cold agglutinin diseases, and some meurologic pathologies.The article presents the main clinical and pathologic features of monoclonal gammopathy and multiple myeloma and describes clinical cases indicative of complicated diagnosis of multiple myeloma and the necessity for continuous monitoring of patients with monoclonal gammopathy.
Ultrasound-Guided Radiofrequency Ablation of Liver Tumors — Analysis of Immediate Outcomes at Gomel Regional Clinical Oncology Center
Authors: Murashko K. L. , Sorokin V. G. 
Published: November 2021

Objective:to systematize the existing techniques of ultrasound-guided percutaneous radiofrequency ablation.Materials.The research subjects were 34 patients with focal liver malignancies who had undergone radiofrequency ablation at Gomel Regional Clinical Oncology Center from 2014 to 2019.Results.The data about the existing techniques of ultrasound-guided percutaneous radiofrequency ablation have been systematized. The possibilities to increase the ablation efficiency of the liver tumor foci have been determined. The main components of the treatment algorithm that allow to achieve the best ablation results have been identified.Conclusion.Strict adherence to the described techniques of radiofrequency ablation which takes into account tumor vascularisation makes it possible to achieve complete necrosis of the foci with no complications in 82.4 % of the patients, and minor complications that do not require therapy in 17.7 % of the patients [9].
Efficiency of the Endovascular Correction of Clinically Evident Degrees of Chronic Obliterating Lower Limb Diseases in Multisegment Lesions
Authors: Gorokhovsky S. Yu. , Lyzikov A. A. , Kaplan M. L. , Tihmanovich V. E. 
Published: November 2021

Objective: to evaluate the efficiency and extent of endovascular revascularization in patients with multisegment lesions in chronic obliterating diseases of the lower limb arteries.Material and methods. The outcomes of the endovascular correction of multisegment lesions of the lower limb arteries were analyzed in 10 patients. Results. After the treatment the patients revealed a statistically significant change (increase of the value) of the ankle-brachial index (ABI) (p = 0.001). The ABI value after the surgical intervention amounted to 0.81 (0.71; 0.87), which was connected with a favourable prognosis for such patients. Аccording to the established criteria, the outcomes of the interventions comprised the decrease of the degree of chronic arterial insufficiency (p < 0.01), all the patients were discharged having no clinical manifestations of critical lower limb ischemia or decreased evidence of intermittent claudication.Conclusion. The majority of patients with clinically evident ischemia of the lower limbs suffer from multisegment arterial lesion (the number of the segments exceeds 2), which entails the need of multiple corrections in one patient. Meanwhile, the evaluation of the treatment results is possible only in the postoperative period according to the indirect criteria. Therefore, during the operation there arises the need to develop a method of the objective intraoperative evaluation of the extent and efficiency of the performed correction of arterial lesions on each segment.
Role of Caudal Blockade in the Modulation of Stress Response in the Surgical Correction of Congenital Malformations of the Lower Parts of the Urogenital System in Children
Authors: Karamyshev A. M. 
Published: November 2021

Objective:to assess the efficiency and safety of an anesthetic technique during the surgical correction of congenital malformations of the lower departments of the urogenital system in children by means of the comparative analysis of laboratory and hemodynamic indices, as well as the course of the early postoperative period, development of adverse effects during the anesthesia.Material and methods.Depending on the type of anesthesia, all patients (127 boys) were divided into 3 clinical groups: those operated under multicomponent balanced inhalation anesthesia (group 1, n = 37), under general laryngeal mask anesthesia in combination with caudal blockade with a local anesthetic solution (group 2, n = 45), under general laryngeal mask anesthesia with caudal blockade with the combination of a local anesthetic solution and adjuvant (group 3, n = 45).Results.The performed analysis of the parameters of hemodynamics, levels of cortisol, glucose, lactate and interleukin-6 (IL-6), as well as the quality, duration, depth of anesthesia and the necessity for an inhalation anesthetic, the assessment of complications and the adverse effects have revealed statistically significant differences indicative of a more effective blockade of the pain sensitivity in the combined application of general and regional anesthesia.Conclusion.The technique of combined anesthesia with the application of the combination of 0.25 % bupivacaine solution and adjuvant to 0.1 % morphine has shown the best efficiency and safety during the surgical correction of congenital malformations of the lower departments of the urogenital system in the children.
Comparative Analysis of the Methods for the Diagnosis of Sleep Disordered Breathing
Authors: Serebrova E. V. , Malkov A. B. , Usova N. N. 
Published: November 2021

Objective: to assess the effectiveness of the diagnosis of sleep apnea syndrome by the methods of respiratory monitoring and polysomnogaphу.Material and methods. 40 patients were examined (19 men and 21 women, their average age was 54 ± 14. All the patients underwent respiratory monitoring and polysomnography.Results. The comparative analysis of the parameters of sleep disordered breathing obtained by the methods of respiratory monitoring and polysomnography has revealed no significant differences in such main diagnostic indicators as index apnea/ hypopnea, apnea index, hypopnea index, snoring index, desaturation index, average SPO2 (p> 0.05). In the diagnosis of sleep apnea syndrome, the method of respiratory monitoring has showed a sensitivity of 96.7 %, specificity of 70.0 %, accuracy of 83.3 %, positive predictive value of 90.6 and negative predictive value of 87.5.Conclusion. Respiratory monitoring is comparable to polysomnography in terms of the main significant diagnostic indicators of sleep disordered breathing and taking in account its cheapness and easiness of performance may serve as an alternative to polysomnography.
Surgical Anatomy of the Extraorganic Anastomoses of the Middle Rectal Artery
Authors: Kuzmenko A. V. 
Published: November 2021

Objective: to determine the topography variants and quantity of the extraorganic anastomoses of the middle rectal artery.Material and methods. 206 cadavers of males (aged 22-82) and 113 cadavers of females (aged 32-93) who had died of accidental causes not related to pelvic pathology were used as the research material. The vascular injection, preparation methods, and statistical analysis of the obtained data were used to achieve the aim of the research.Results. It has been found out that most often the extraorganic anastomoses of the middle rectal artery are formed in the proximal and middle thirds of the artery, significantly rarely - in its distal third. A linear correlation between the sizes of the diameters of the internal pudendal artery and the sizes of the diameters of its extraorganic anastomoses has been detected in the males and females.Conclusion. The performed research has demonstrated that the extraorganic anastomoses of the middle rectal artery in males and females have a definite pattern of origination.
Variety in Topography of Small Saphenous Vein in the Popliteal Fossa
Authors: Semeniaha S. A. , Zhdanovich V. N. 
Published: November 2021

Objective: to describe the possible types of the interrelations of the small saphenous vein and popliteal vein within the area of the popliteal fossa, as well as to study the distribution of the types among patients of both the genders and different somatotypes.Material and methods. 163 patients (326 extremities) of both the genders without signs of vascular pathology were examined by the method of duplex ultrasound scanning. According to Chernorutsky`s classification, the patients were divided into three groups: dolihomorphs, mesomorphs, brachymorphs. The percentage of different types of the topography of the small saphenous vein was calculated among the examined patients.Results. The term “saphenopopliteal pattern” has been introduced to characterize the anatomical interrelation of the small saphenous vein and popliteal vein within the area of the popliteal fossa. Five basic saphenopopliteal patterns were described including rare ones when the small saphenous vein opens into the gastrocnemius veins. It has been found that the patterns with the saphenopopliteal junction prevail (65.6 %), and in 28.3 % cases the small saphenous vein did not have any connection with the popliteal vein. The gender factor does not have any effect on the pattern type (р = 0.311) but the somatotype factor does (р = 0.038). It has also been determined that there is no direct connection between the small saphenous vein and popliteal vein in one thirds cases in the dolihomorphic and mesomorphic patients (34.5 % and 35 %, respectively), whereas the saphenopopliteal junction develops in 85.7 % cases in the brachymorphic patients.Conclusion. The proposed classification of the types of the topography of the small saphenous vein within the area of the popliteal fossa could be applied for the evaluation of the venous beds of the lower extremities by the method of duplex ultrasound scanning.
Bacteriological Profile of Wounds of Patients with Neuroischemic Form of Diabetic Foot
Authors: Silvistrovich V. I. , Lyzikov A. A. , Kaplan M. L. , Yarets J. I. 
Published: November 2021

Objective: to assess the results of the microbiological study of wounds in patients with diabetic foot syndrome (DFS).Material and methods. The microbiological study of the wounds of 76 patients with the neuroischemic form of DFS having undergone inpatient treatment at Gomel Regional Diabetic Foot Center from 2016 to 2019 was performed.Results. The range of the microbial flora of the wounds of the patients with the neuroischemic form of DFS has been identified, the antibiotic susceptibility of the detected bacteria to antibacterial drugs has been analyzed.Conclusion. The microbiological profile of the wounds of the patients with the neuroischemic form of DFS was characterized by the variety of bacteria and included Enterococcusfaecalis (29%), Staphylococcusaureus (19%), as well as representatives of Enterobacteriaceae family (25%). The detected bacteria were most sensitive to glycopeptides, aminoglycosides, carbapenems, which makes it reasonable to prescribe these groups of antibiotics as the start antibacterial therapy.
Effectiveness of Palliative Care in Patients with Malignant Neoplasms of II and IV Clinical Groups
Authors: Litvinov G. E. , Usova N. N. , Ksenzov N. L. , Voronina A. P. , Pukhovich O. S. 
Published: November 2021

Objective: to evaluate the effectiveness of palliative care in patients with malignant neoplasms of II and IV clinical groups in terms of the changes of the quality of life indicators regardless of the stage of the development of the disease and the degree of its malignancy. Material and methods. 61 patients of the Palliative Care Ward suffering from malignant neoplasms of II and IV clinical groups were examined at the beginning (day 2) and at the end of the treatment course (day 14). The patients' psychoemotional condition, characteristics of pain syndrome and clinical mobility were analyzed. The effectiveness of the palliative care course was evaluated using the standardized questionnaires and scales: visual-analog pain scale, DN4, Pain Detect, Rivermid Mobility Index, Beck Depression Inventory, Spielberger-Hanin Anxiety Scale (assessment of situational and personal anxiety). The Garkawi Adaptation Intensity Index was used to calculate the body's reactivity to the disease at the beginning and upon completion of the palliative care course. The Calf-Caliph leukocyte index was calculated twice to assess the dynamics of endogenous intoxication.Results. The course of the inpatient palliative treatment has showed its effectiveness by improving the category of clinical mobility on the Rivermid scale and the psychological condition of the patients with malignant neoplasms of II and IV clinical groups: there was a decrease in anxiety and depression, some decrease in the degree of pain syndrome. The Garkawi and Calf-Caliph indices were not effective tools for the assessment of the short treatment course.Conclusion. Inpatient palliative care for patients with malignant neoplasms of II clinical group reduces undesirable effects of radical treatment, thus improving the quality of life, and it relieves the suffering in the patients of IV clinical group in whom the application of radical methods is not possible.
Prevalence of non-conventional risk factors among patients with chronic obliterating diseases of lower limb arteries
Authors: Kulikovich Y. K. , Sharshakova T. M. , Lyzikov A. A. , Kulikovich D. B. 
Published: November 2021

Objective: to study the prevalence of non-conventional risk factors among patients with chronic obliterating diseases of lower limb arteries.Material and methods. To identify the non-conventional risk factors among patients, the Hospital Anxiety and Depression Scale (HADS), DS-14 questionnaire were used. The survey included 250 patients with chronic obliterating diseases of lower limb arteries (men - 192 patients (76.8 %), women - 58 (23.2 %). The statistical analysis of the data was carried out by means of the program «Statistica» 8.0. Differences between the groups were considered as statistically significant at p < 0.05.Results. Anxiety symptoms were observed in 53.2 % of the patients. The average HADS-A subscale score was 8.0 (5.0; 9.0) points. Symptoms of hospital depression were observed in 38.4 % of the patients. The average HADS-D subscale score in all the patients was 6.0 (4.0; 9.0) points. Personality type D was detected in 51.2 % of the patients.
Advantages and disadvantages of the use of eHealth technologies during the COVID-19 pandemic
Authors: Semutenko K. M. , Sharshakova T. M. 
Published: November 2021

Objective: to evaluate the experience and possibilities of the use of eHealth technologies during the pandemic.Material and methods. A systematic review of literature containing information about the use of telemedicine, crowdsourcing monitoring and other eHealth resources during the COVID-19 pandemic was performed. Results. The main advantages and disadvantages of the use of eHealth technologies have been highlighted, the main problems arising on the way of their implementation have been identified and options for their solution have been proposed.Conclusion. In developed countries the COVID-19 pandemic has already accelerated the implementation of eHealth as a tool to combat the pandemic. But despite this, new laws and regulations governing liability in the field of remote treatment are needed, as well as guidelines regarding the use of crowdsourcing disease monitoring systems in addition to traditional epidemiological surveillance systems.