bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rancangan Prototype Layanan Pengaduan Masyarakat Melalui Kantor Desa Berbasis Android
Authors: Yurindra Yurindra , Sarwindah Sarwindah , Irawan Devi 
Published: December 2021

Salah satu Peningkatan kualitas pelayanan public bagi masyarakat pedesaan adalah dapat dengan dilakukan melalui sebuah penyelesaian pengaduan yang mendapatkan respon yang cepat dari penyedia layanan yaitu dalam hal ini instansi pemerintah terkait baik di pusat maupun daerah. Segala bentuk kritik, saran maupun aduan yang disampaikan masyarakat pada suatu instansi merupakan sebuah koreksi untuk perbaikan pelayanan tersebut. Banyak Kantor Desa di Indonesia belum memiliki sistem layanan pengaduan yang teridentifikasi dan terdokumentasi dengan baik, sehingga timbul kendala dalam memberikan layanan pengaduan kepada masyarakat, seperti respon time pelayanan yang lambat dan dokumentasi pengaduan tidak tertata dengan rapi. Kendala lain timbul saat masyarakat kebingungan untuk menyampaikan keluhan tersebut dikarenakan tidak mengetahui harus mengadu kemana. Untuk mengatasi masalah tersebut, akan dirancang aplikasi layanan pengaduan berbasis Android yang menggunakan model prototype dan menggunakan MySql sebagai database pada server yang digunakan. Dengan itu diharapkan agar dapat memudahkan masyarakat dalam membuat laporan pengaduan. Aplikasi Android ini dapat digunakan masyarakat untuk melakukan layanan pengaduan secara online. Aplikasi ini juga dapat memudahkan Pemerintah desa dan kabupaten dalam melakukan dokumentasi dan mengevaluasi sistem layanan pengaduan masyarakat desa.
Perbandingan Klassifikasi SMS Berbasis Support Vector Machine, Naive Bayes Classifier, Random Forest dan Bagging Classifier
Authors: Irawan Devi , Perkasa Eza Budi , Yurindra Yurindra , Wahyuningsih Delpiah , Helmud Ellya 
Published: December 2021

Short message service (SMS) adalah salah satu media komunikasi yang penting untuk mendukung kecepatan pengunaan ponsel oleh pengguna. Sistem hibrid klasifikasi SMS digunakan untuk mendeteksi sms yang dianggap sampah dan benar. Dalam penelitian ini yang diperlukan adalah mengumpulan dataset SMS, pemilihan fitur, prapemrosesan, pembuatan vektor, melakukan penyaringan dan pembaharuan sistem. Dua jenis klasifikasi SMS pada ponsel saat ini ada yang terdaftar sebagai daftar hitam (ditolak) dan daftar putih (diterima). Penelitian ini menggunakan beberapa algoritma seperti support vector machine, Naïve Bayes classifier, Random Forest dan Bagging Classifier. Tujuan dari penelitian ini adalah untuk menyelesaikan semua masalah SMS yang teridentifikasi spam yang banyak terjadi pada saat ini sehingga dapat memberikan masukan dalam perbandingan metode yang mampu menyaring dan memisahkan sms spam dan sms non spam. Pada penelitian ini menghasilkan bahwa Bagging classifier algorithm ini mendapatkan ferformance score tertinggi dari algoritma yang lain yang dapat dipergunakan sebagai sarana untuk memfiltrasi SMS yang masuk ke dalam inbox pengguna dan Bagging classifier algorithm dapat memberikan hasil filtrasi yang akurat untuk menyaring SMS yang masuk.
Riscos na arrematação de imóvel residencial em leilão
Authors: Zavoiski Vanessa , Sales Caroline Samara Garcia , Guarise Marinei 
Published: December 2021

No presente contexto, a procura por imóveis com preço abaixo do valor de mercado, tem tornado o leilão judicial uma opção atrativa para a aquisição de bens. Nesse sentido, este artigo visa demonstrar de forma sucinta quais são os riscos mais comuns que o arrematante terá ao adquirir um imóvel residencial por meio de leilão judicial. O assunto tem amplo panorama jurídico e múltiplas regras administrativas, que ao arrematante é de suma importância sua análise, planejamento e conhecimento prévio. A grande maioria dos imóveis leiloados está ocupado, seja com o proprietário, inquilinos, terceiros ou invasores. Esse cenário gera de imediato uma preocupação aos compradores, pois muitas vezes, os direitos do arrematante são desconhecidos. A presente pesquisa apresenta uma explicação do funcionamento dos leilões e análise dos fatores que devem ser previamente analisados e verificados antes da arrematação. Por meio dos achados evidenciados na pesquisa possível observarem que o conteúdo apresentado não esgota o tema, pois diversidade da interpretação e entendimento do judiciário é particular de cada processo, conforme evidenciado pelos entrevistados. Por meio do presente estudo pode-se concluir que o apesar de o leilão judicial ter se tornado uma forma acessível de aquisição imobiliária, entretanto, nem sempre o desembaraço do bem trâmita de forma rápida e tranquila.
Exercise-Induced Cardiac Fatigue in Soldiers Assessed by Echocardiography
Authors: Charton Marion , Kervio Gäelle , Matelot David , Lachard Thibault , Galli Elena , Donal Erwan , Carré François , Le Douairon Lahaye Solène , Schnell Frédéric 
Published: December 2021

Background: Echocardiographic signs of exercise-induced cardiac fatigue (EICF) have been described after strenuous endurance exercise. Nevertheless, few data are available on the effects of repeated strenuous exercise, especially when associated with other constraints as sleep deprivation or mental stress which occur during military selection boot camps. Furthermore, we aimed to study the influence of experience and training level on potential EICF signs.Methods: Two groups of trained soldiers were included, elite soldiers from the French Navy Special Forces (elite; n = 20) and non-elite officer cadets from a French military academy (non-elite; n = 38). All underwent echocardiography before and immediately after exposure to several days of uninterrupted intense exercise during their selection boot camps. Changes in myocardial morphology and function of the 4 cardiac chambers were assessed.Results: Exercise-induced decrease in right and left atrial and ventricular functions were demonstrated with 2D-strain parameters in both groups. Indeed, both atrial reservoir strain, RV and LV longitudinal strain and LV global constructive work were altered. Increase in LV mechanical dispersion assessed by 2D-strain and alteration of conventional parameters of diastolic function (increase in E/e' and decrease in e') were solely observed in the non-elite group. Conventional parameters of LV and RV systolic function (LVEF, RVFAC, TAPSE, s mitral, and tricuspid waves) were not modified.Conclusions: Alterations of myocardial functions are observed in soldiers after uninterrupted prolonged intense exercise performed during selection boot camps. These alterations occur both in elite and non-elite soldiers. 2D-strain is more sensitive to detect EICF than conventional echocardiographic parameters.
Associations Between Healthy Lifestyle Trajectories and the Incidence of Cardiovascular Disease With All-Cause Mortality: A Large, Prospective, Chinese Cohort Study
Authors: Ding Xiong , Fang Wei , Yuan Xiaojie , Seery Samuel , Wu Ying , Chen Shuohua , Zhou Hui , Wang Guodong , Li Yun , Yuan Xiaodong , Wu Shouling 
Published: December 2021

Background: Lifestyles generally change across the life course yet no prospective study has examined direct associations between healthy lifestyle trajectories and subsequent cardiovascular disease (CVD) or all-cause mortality risk.Methods: Healthy lifestyle score trajectories during 2006–2007, 2008–2009, and 2010–2011 were collated through latent mixture modeling. An age-scale based Cox proportional hazard regression model was implemented to calculate hazard ratios (HR) with corresponding 95% confidence intervals (CI) for developing CVD or all-cause mortality across healthy lifestyle trajectories.Results: 52,248 participants were included with four distinct trajectories identified according to healthy lifestyle scores over 6 years i.e., low-stable (n = 11,248), high-decreasing (n = 7,374), low-increasing (n = 7,828), and high-stable (n = 25,799). Compared with the low-stable trajectory, the high-stable trajectory negatively correlated with lower subsequent risk of developing CVD (HR, 0.73; 95% CI, 0.65–0.81), especially stroke (HR, 0.70; 95% CI, 0.62–0.79), and all-cause mortality (HR, 0.89; 95% CI, 0.80–0.99) under a multivariable-adjusted model. A protective effect for CVD events was observed only in men and in those without diabetes, while a reduced risk of all-cause mortality was observed only in those older than 60 years, though interactions were not statistically significant. Marginally significant interactions were observed between the changing body mass index (BMI) group, healthy lifestyle score trajectories and stratified analysis. This highlighted an inverse correlation between the high-stable trajectory and CVD in BMI decreased and stable participants as well as all-cause mortality in the stable BMI group. The low-increasing trajectory also had reduced risk of CVD only when BMI decreased and in all-cause mortality only when BMI was stable.Conclusions: Maintaining a healthy lifestyle over 6 years corresponds with a 27% lower risk of CVD and an 11% lower risk in all-cause mortality, compared with those engaging in a consistently unhealthy lifestyle. The benefit of improving lifestyle could be gained only after BMI change is considered further. This study provides further evidence from China around maintaining/improving healthy lifestyles to prevent CVD and early death.
Benefit and Risk of Prolonged Dual Antiplatelet Therapy After Percutaneous Coronary Intervention With Drug-Eluting Stents in Patients With Elevated Lipoprotein(a) Concentrations
Authors: Cui Kongyong , Wang Hao-Yu , Yin Dong , Zhu Chenggang , Song Weihua , Wang Hongjian , Jia Lei , Zhang Dong , Song Chenxi , Feng Lei , Dou Kefei 
Published: December 2021

Background: Lipoprotein(a) is positively related to cardiovascular events in patients with coronary artery disease (CAD). Given that lipoprotein(a) has a prothrombotic effect, prolonged dual antiplatelet therapy (DAPT) might have a beneficial effect on reducing ischemic events in patients with elevated lipoprotein(a) levels after percutaneous coronary intervention (PCI). We performed this study to assess the efficacy and safety of prolonged DAPT (&gt;1 year) in this population.Methods: We evaluated a total of 3,025 CAD patients with elevated lipoprotein(a) levels who were event-free at 1 year after PCI from the prospective Fuwai PCI Registry, of which 913 received DAPT ≤ 1 year and 2,112 received DAPT&gt;1 year. The primary endpoint was major adverse cardiovascular and cerebrovascular event (MACCE), defined as a composite of all-cause death, myocardial infarction or stroke.Results: After a median follow-up of 2.4 years, patients who received DAPT&gt;1 year were associated with lower risks of MACCE compared with DAPT ≤ 1 year (1.6 vs. 3.8%; hazard ratio [HR] 0.383, 95% confidence interval [CI] 0.238–0.616), which was primarily driven by the lower all-cause mortality (0.2 vs. 2.3%; HR 0.078, 95% CI 0.027–0.227). In addition, DAPT&gt;1 year was also associated with lower risks of cardiac death, and definite/probable stent thrombosis than those who received DAPT ≤ 1 year (P &lt; 0.05). Conversely, no difference was found between the two groups in terms of clinically relevant bleeding. Similar results were observed in multivariate Cox regression analysis and inverse probability of treatment weighting analysis.Conclusions: In patients with elevated lipoprotein(a) concentrations after PCI, prolonged DAPT (&gt;1 year) reduced ischemic cardiovascular events, including MACCE, all-cause mortality, cardiac mortality, and definite/probable stent thrombosis, without increase in clinically relevant bleeding risk compared with ≤ 1-year DAPT. Lipoprotein(a) levels might be a new important consideration when deciding the duration of DAPT after PCI.
Investigating the Causal Relationship Between Physical Activity and Chronic Back Pain: A Bidirectional Two-Sample Mendelian Randomization Study
Authors: Gao Shaowei , Zhou Huaqiang , Luo Siyu , Cai Xiaoying , Ye Fang , He Qiulan , Huang Chanyan , Zheng Xiaoyang , Li Ying , Du Zhanxin , Wang Yaqing , Qi Zhihui , Wang Zhongxing 
Published: December 2021

Background: Recent observational studies have reported a negative association between physical activity and chronic back pain (CBP), but the causality of the association remains unknown. We introduce bidirectional Mendelian randomization (MR) to assess potential causal inference between physical activity and CBP.Materials and Methods: This two-sample MR used independent genetic variants associated with physical activity and CBP as genetic instruments from large genome-wide association studies (GWASs). The effects of both directions (physical activity to CBP and CBP to physical activity) were examined. Inverse variance-weighted meta-analysis and alternate methods (weighted median and MR-Egger) were used to combine the MR estimates of the genetic instruments. Multiple sensitivity analyses were conducted to examine the robustness of the results.Results: The MR set parallel GWAS cohorts, among which, those involved in the primary analysis were comprised of 337,234 participants for physical activity and 158,025 participants (29,531 cases) for CBP. No evidence of a causal relationship was found in the direction of physical activity to CBP [odds ratio (OR), 0.98; 95% CI, 0.85–1.13; p = 0.81]. In contrast, a negative causal relationship in the direction of CBP to physical activity was detected (β = −0.07; 95% CI, −0.12 to −0.01; p = 0.02), implying a reduction in moderate-vigorous physical activity (approximately 146 MET-minutes/week) for participants with CBP relative to controls.Conclusion: The negative relationship between physical activity and CBP is probably derived from the reduced physical activity of patients experiencing CBP rather than the protective effect of physical activity on CBP.
Daratumumab Prevents Experimental Xenogeneic Graft-Versus-Host Disease by Skewing Proportions of T Cell Functional Subsets and Inhibiting T Cell Activation and Migration
Authors: Gao Yang , Shan Wei , Gu Tianning , Zhang Jie , Wu Yibo , Li Xiaoqing , Zeng Xiangjun , Zhou Hongyu , Chen Zhi , Xiao Haowen 
Published: December 2021

Graft-versus-host disease (GVHD) remains the major cause of mortality and morbidity in non-relapse patients after allogeneic hematopoietic cell transplantation (allo-HCT). As the number of patients undergoing allo-HCT increases, it will become imperative to determine safe and effective treatment options for patients with GVHD, especially those who become refractory to systemic steroid therapy. Daratumumab (Dara), a humanized IgG1 (ĸ subclass) monoclonal antibody targeting the CD38 epitope, is used for the treatment of multiple myeloma. CD38 is a multifunctional ectoenzyme that behaves either as an enzyme, a cell adhesion molecule or a cell surface receptor involved in cell signaling. CD38 is also expressed on various immune effector and suppressor cells. However, the role of CD38 in the immune response remains elusive. We questioned whether CD38 is a potential therapeutic target against alloreactive T cells in the GVHD pathological process. Here, we investigated the impact of Dara on xenogeneic GVHD (xeno-GVHD) and graft-versus-leukemia (GVL) effects in a humanized murine model of transplantation, where human peripheral blood mononuclear cells were adoptively transplanted into immunocompromised NOD.SCID.gc-null (NSG) mice. Mice receiving Dara treatment experienced less weight loss, longer survival and lower GVHD scores compared with those in the control group. Histological evaluations, flow cytometry, RNA-sequencing and RT-qPCR analysis revealed that Dara efficaciously mitigated GVHD through multiple mechanisms including inhibition of the proliferation, activation and differentiation of CD8+ cytotoxic T cells, reduced expression of cytotoxic effector molecules, pro-inflammatory cytokines, chemokines and chemoattractant receptors by T cells and promotion of immunosuppressive T cells. More importantly, Dara preserved the GVL effect in a humanized mouse model of leukemia by metabolic reprograming of T cells to promote the induction of Th17, Th1/17and Tc1/17 cells. Our findings indicate that Dara may be an attractive therapeutic option to separate GVHD from GVL effects in patients with hematopoietic malignancies receiving allo-HCT.
Establishing in vitro and in vivo Co-culture Models of Staphylococcus epidermidis and Enterococcus faecalis to Evaluate the Effect of Topical Fluoroquinolone on Ocular Microbes
Authors: Kim Han Woo , Kim Jiyeun Kate , Park Indal , Lee Sang Joon 
Published: December 2021

Purpose: To establish in vitro and in vivo ocular co-culture models of Staphylococcus epidermidis and Enterococcus faecalis and to study how various concentrations of moxifloxacin affect the survival of these two endophthalmitis-causing bacteria.Methods: Standard strains of S. epidermidis and E. faecalis were used. Color detection agar plates were employed to distinguish their colonies. To establish the in vitro and in vivo co-culture models, S. epidermidis and E. faecalis were co-cultivated at different ratios for various periods. For the in vivo model, various volumes and concentrations of either a mono-culture or co-culture were inoculated into the lower conjunctival sac of rabbits. Finally, the newly developed in vitro and in vivo co-culture models were subjected to the moxifloxacin treatment to access its effect on S. epidermidis and E. faecalis.Results: When S. epidermidis and E. faecalis were cultured separately in tryptic soy broth, their growth peaked and plateaued at approximately 16 and 6 h, respectively. When they were co-cultured, the growth peak of S. epidermidis got delayed, whereas the growth peak of E. faecalis did not change. The number of E. faecalis was significantly higher in the co-culture than that in the mono-culture. Treatment with moxifloxacin in the in vitro co-culture model rapidly decreased the number of S. epidermidis cells at doses ≥ 0.125 μg/ml. In contrast, the number of E. faecalis did not change significantly up to 16 μg/ml moxifloxacin. In in vivo co-culture (at 1:1), the S. epidermidis count decreased in a pattern similar to that seen in in vivo mono-culture and was barely detectable at 24 h after inoculation. In contrast, the of E. faecalis count increased up to 16 h and then decreased. When moxifloxacin was applied (zero, one, or two times) to this model, the S. epidermidis count decreased in proportion to the number of treatments. In contrast, the E. faecalis count increased with moxifloxacin treatment.Conclusions: The in vitro and in vivo co-culture models of S. epidermidis and E. faecalis were established to determine the influence of moxifloxacin eye drops on these bacteria. The results clearly show that the moxifloxacin eye drops can make E. faecalis dominant on the ocular surface.
Combined Analysis of the Effects of Exposure to Blue Light in Ducks Reveals a Reduction in Cholesterol Accumulation Through Changes in Methionine Metabolism and the Intestinal Microbiota
Authors: Xia Daiyang , Yang Lin , Cui Jiajie , Li Yu , Jiang Xianzhi , Meca Giuseppe , Wang Shunxiang , Feng Yan , Zhao Yujie , Qin Jiangfan , Zhu Yongwen , Ye Hui , Wang Wence 
Published: December 2021

Graphical AbstractBlue light improves lipid metabolism by altering metabolism and gut microbes.
Cord Blood Thyroid Hormones and Neurodevelopment in 2-Year-Old Boys and Girls
Authors: Fan Pianpian , Chen Yuanzhi , Luo Zhong-Cheng , Shen Lixiao , Wang Weiye , Liu Zhiwei , Zhang Jun , Ouyang Fengxiu 
Published: December 2021

Objective: Thyroid hormones are essential for neurodevelopment in early life. However, the impact of mild alterations in neonatal thyroid hormones on infant neurodevelopment and its sex dimorphism is unclear. We aimed to assess whether mild variations in neonatal thyroid hormones of term-born newborns with maternal euthyroid are related to neurodevelopment in 2-year-old boys and girls.Methods: This study used data from 452 singleton term-born infants of mothers with normal thyroid function in Shanghai, China, and their follow-up measure at the age of 2 years. Cord serum concentrations of free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), and thyroid peroxidase antibody (TPOAb) were measured by chemiluminescent microparticle immunoassays and classified into three groups: the low (1st, Q1), middle (2nd−4th, Q2–Q4), and high (5th, Q5) quintiles. Neurodevelopment indices were assessed using the Ages and Stages Questionnaire, third edition (ASQ-3), at 24 months of age.Results: Compared to infants with thyroid hormones in the middle (Q2–Q4), boys with FT4 in the lowest quintile had 5.08 (95% CI: 1.37, 8.78) points lower scores in the communication domain, 3.25 (0.25,6.25) points lower scores in the fine motor domain, and 3.84 (0.04, 7.64) points lower scores in the personal-social domain, respectively. Boys with FT3 in the highest quintile had 4.46 (0.81, 8.11) points increase in the personal-social domain. These associations were not observed in girls. No associations were observed between cord blood serum TSH and ASQ-assessed neurodevelopment in the boys or the girls.Conclusions: Mild alterations in thyroid hormones of newborns were associated adversely with neurodevelopment in boys, suggesting the importance of optimal thyroid hormone status for neurodevelopment in early life.
Neurological Outcome Following Newborn Encephalopathy With and Without Perinatal Infection: A Systematic Review
Authors: Andersen Mads , Pedersen Mette Vestergård , Andelius Ted Carl Kejlberg , Kyng Kasper Jacobsen , Henriksen Tine Brink 
Published: December 2021

Background: Studies have suggested that neurological outcome may differ in newborns with encephalopathy with and without perinatal infection. We aimed to systematically review this association.Methods: We conducted this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Studies were obtained from four databases including Pubmed, Embase, Web of Science, and The Cochrane Database. Newborns with encephalopathy with and without markers of perinatal infection were compared with regard to neurodevelopmental assessments, neurological disorders, and early biomarkers of brain damage. Risk of bias and quality of evidence were assessed by the Newcastle-Ottawa scale and Grading of Recommendations Assessment, Development and Evaluation (GRADE).Results: We screened 4,284 studies of which eight cohort studies and one case-control study met inclusion criteria. A narrative synthesis was composed due to heterogeneity between studies. Six studies were classified as having low risk of bias, while three studies were classified as having high risk of bias. Across all outcomes, the quality of evidence was very low. The neurological outcome was similar in newborns with encephalopathy with and without markers of perinatal infection.Conclusions: Further studies of higher quality are needed to clarify whether perinatal infection may affect neurological outcome following newborn encephalopathy.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42020185717.