bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of different endometrial preparation protocols on pregnancy outcomes in frozen- embryo transfer cycles: a retrospective cohort study
Authors: Qian Yue , Wan Qi , Bu Xiao-Qing , Li Tian , Tang Xiao-Jun , Jia Yan , Feng Qian , Lv Xing-Yu , Meng Xiang-Qian , Yang Yin , Ding Yu-Bin , Geng Li-Hong , Xia Min , zhong zhaohui 
Published: October 2021

Abstract
Background

Owing to the crucial role the endometrium plays in embryo implantation, the four main endometrial preparation protocols have become important factors in the study of pregnancy outcomes in the FET cycles. Previous studies have shown that the best of these four protocols remains controversial for women undergoing FET.
Methods

A total of 10333 FET cycles from January 2018 to December 2018 were analyzed in this study. They were categorized into four groups according to endometrial preparation regimen: natural cycles (Group NC,n = 815), hormone replacement therapy cycles (Group HRT ,n = 6434), GnRH agonist artificial cycles (Group GAC,n = 1392) and ovarian stimulation cycles (Group OC, n = 1692). All patients were followed up for at least 1 year. Pregnancy outcomes were compared between the four groups and multiple logistic regression models were used to adjust for the effects of confounding factors.
Results

The ectopic pregnancy rate (P = 0.627) and miscarriage rate (P = 0.164) were not statistically significant between the four groups. Moreover, biochemical pregnancy rate, clinical pregnancy rate and live birth rate in the NC group were not statistically significant compared to the other three groups. After adjusting for covariates, multiple logistic regression analysis showed no statistical significance in pregnancy outcomes in the HRT, GAC and OC groups compared to the NC group.And the adjusted OR for live births was 0.988 (95 % CI0.847-1.152) for the HRT group, 0.955 (95 % CI0.795-1.146) for the GAC group,0.898 (95 % CI0.754-1.070) for the OC group.
Conclusions

Our study showed that natural cycles have similar pregnancy outcomes in terms of clinical pregnancy and live birth to the other three endometrial preparation options. As it has other advantages, the natural cycle protocol can therefore be the recommended option for endometrial preparation in the FET population.
Adaptive Finite-time Synergetic Control of Delta Robot based on Radial basis Function Neural Networks
Authors: Pham Phu-Cuong , Kuo Yong-Lin 
Published: October 2021

Abstract
This paper proposes a novel robust proportional derivative adaptive non-singular synergetic control (PDATS) for the delta robot system. A proposal radial basis function approximation neural networks (RBF) compensates for external disturbances and uncertainty parameters. To counteract the chattering noise of the low-resolution encoder, a second-order sliding mode (SOSM) observer in the feedback loop showed the ability to obtain the angular velocity estimations. The stability of the PDATS approach is proven using the Lyapunov stability theory. Both the simulation and experiment result effectiveness and performances of the PDATS controller in trajectory; pick and place operations of a parallel delta robot. The characteristics of the controller demonstrate that the proposed method can effectively reduce external disturbance and uncertainty parameters of the robot by a convergent finite-time, and provide higher accuracy in comparison with finite-time synergetic control and PD control.
WITHDRAWN: Network Pharmacology and Molecular Docking Study of Jinwei Decoction for Enhancement of Glucocorticoid Anti-Inflammatory Effect in COPD through miR-21
Authors: wu jianjun , Zhang Ping-an , Chen Ming-zhe , Li Yi-xuan , Zhang Ying-xue , Jiang Liang-duo , Jiao Yang , Li Xin 
Published: October 2021

Abstract
PurposeJinwei decoction can enhance the anti-inflammatory effect of glucocorticoid (GC) on chronic obstructive pulmonary disease (COPD) by restoring the activity of HDAC2. But the upstream mechanism of Jinwei decoction on HDAC2 expression is not clear. ObjectiveTo explore whether Jinwei decoction can enhance the anti-inflammatory effect of GC on COPD through microRNA21 (miR-21) by network pharmacology. MethodsThe TCMSP database was used to screen active ingredients and target genes of Jinwei decoction, and miRWalk2.0 was used to predict downstream target genes of miR-21. COPD-related genes were identified by searching GeneCards and OMIM databases; Venny 2.1 was used to screen intersection genes; Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of intersection genes were analyzed by R software. Protein-protein interactions (PPIs) were analyzed by Cytoscape 3.7.2 software to identify core genes. Finally, interactions between main compounds and potential targets were verified by molecular docking. ResultsTwo hundred ninety-two active ingredients, 316 Jinwei drug targets, 10170 miR-21 target genes, 6617 COPD target genes, and 184 intersection gene were identified. Eleven core proteins of PPI networks may be involved. GO enrichment analysis showed that oxidative stress, regulation of inflammatory response, hormone transport, and histone modification were involved; KEGG pathway enrichment analysis concentrated in the PI3K-Akt, mitogen-activated protein kinase (MAPK), HIF-1, neutrophil extracellular bactericidal network, and other signaling pathways. ConclusionJinwei decoction can regulate histone deacetylase-2 activity and enhance the anti-inflammatory effect of GC on COPD by modulating miR-21. Its mechanism of action may be related to its effect on the PI3K Akt, MAPK, and TNF signaling pathways and neutrophil extracellular trap formation through miR-21.
No Evidence of Uptake or Propagation of Reindeer CWD Prions in Environmentally Exposed Sheep
Authors: Harpaz Erez , Ersdal Cecilie , Tranulis Michael , Espenes Arild , Salvesen Øyvind , Mahmood Aqsa , Rauset Geir Rune , Ytrehus Bjørnar , Benestad Sylvie , Tran Linh 
Published: October 2021

Abstract
Background: Chronic wasting disease (CWD) is a prion disease of cervids. In 2016, CWD was discovered for the first time in reindeer. The affected population was situated in Nordfjella mountain region in Norway. In an attempt to eradicate the disease, all reindeer in the region were culled during winter 2017-18. Because many sheep have their summer pasture in Nordfjella, concern exists about the potential cross-species transmission of CWD to sheep. In this study, global positioning system (GPS) data from sheep and reindeer from the relevant time frame were analyzed to determine spatial overlap. Samples of gut-associated lymphoid tissue (GALT) from 503 lambs and sheep having grazed in the region were analyzed for the presence of prions. The rectoanal mucosa-associated lymphoid tissue (RAMALT) from all animals and ileal Peyer's patch (IPP) from 37 of them, were examined by histology, immunohistochemistry (IHC), and enzyme-linked immunosorbent assay (ELISA). Results: GPS data showed a direct overlap in area use between an infected reindeer and some of the sampled sheep. Generally, the sampled sheep herding areas were used intensively by reindeer before culling. No prions were detected in the GALT of sheep. The mean lymphoid follicle number per sample was 22.6 for RAMALT and 37.5 for IPP. Conclusion: Despite evidence of close reindeer to sheep interaction and spatial overlap in Nordfjella, prions were not detected in the GALT of sheep.. We document that the easily accessible RAMALT tissue at the mucocutaneous border is well suitable for slaughterhouse screening of prions in sheep.
Methylation level of ASC/TMS1 and MyD88 genes in healthy larynx and laryngeal carcinoma tissue
Authors: Bilic Lana Kovac , Knezevic Jelena , Sutic Maja , Branica Srecko , Dawidowsky Krsto , Bilic Mario 
Published: October 2021

Abstract
There are no biomarkers for diagnosis, prognosis and treatment of patients with laryngeal carcinoma. Methylation changes of ASC/TMS1 and MyD88 genes, in healthy and cancer tissue, might be related with development and progression of cancer. The study explored is there a difference in gene’s methylation in healthy and tumor tissue and does it correlate with protein expression. The total of 36 patients were enrolled in the study. Methylation of bisulphite converted DNA was quantified by pyrosequencing in fresh frozen cancer and adjacent non-malignant tissues. The overall methylation of MyD88 gene is significantly higher in healthy tissue and this finding correlates with protein expression and the overall methylation of ASC/TMS1 gene is unchanged but the protein expression of ASC/TMS1 is significantly higher in cancer. The methylation status of the ASC/TMS1 and MyD88 genes are promising prognostic biomarker candidates and may lead to earlier detection of laryngeal cancer.
Characteristics And Prognostic Value of Lymph Node Metastasis Along Recurrent Laryngeal Nerves in Thoracic Esophageal Squamous Cell Carcinoma
Authors: Yuan Ligong , Li Feng , Gao Shugeng , Mao Yousheng , he jie 
Published: October 2021

Abstract
Background: Though the value of lymph node (LN) dissection along bilateral recurrent laryngeal nerve (RLN) has been debated and emphasized in recent years in thoracic esophageal squamous cell carcinoma (ESCC). However, the characteristics of nodal metastasis along RLN chain has not been clarified. This study aimed to investigate the characteristics of nodal metastasis along recurrent laryngeal nerves and the influence of these metastasis on the prognosis of thoracic ESCC.Patients and Methods: 339 eligible patients with thoracic ESCC who underwent esophagectomy with a three-field(3-FL) or two-field(2-FL) lymph node dissection from March 2015 to December 2018 were included in this study, consisting of 282 males and 57 females with a mean age of 60.6 years (range,40-80 years). The association of LN metastasis near RLN with clinicopathologic factors and its influence on survival were analyzed. Results: Among the 339 patients, 96 (28.3%) had LN metastasis along bilateral recurrent laryngeal nerves, 76 (22.4%) with positive LNs along right RLN and 47 (13.9%) along the left RLN. There was a significant difference in the metastasis rate between the LNs along right RLN and along the left RLN (P=0.004). The LN metastasis rate along RLN was significantly correlated with primary tumor locations (upper vs middle vs lower: 35.1% vs 30.9% vs 15.6%; P=0.015), tumor invasion depth (T3/T4 vs T1 vs T2: 36.2% vs 15.8% vs 26.2%, P=0.001 ) and degree of differentiation (well vs moderately vs poorly: 9.3% vs 29.3% vs 33.9%; P=0.009), subcarinal and left tracheobronchial lymph node metastasis (positive vs negative:58.1% vs 25.3%, P＜0.001), abdominal LN metastasis (positive vs negative:41.2% vs 24.0%, P=0.003 ), but was not significantly correlated with age, gender and tumor length. The median follow-up time for this study was 34 months. The cumulative 1-, 2- and 3-year overall survival rates were 95.7%, 86.6% and 82.2% in RLN-LN(-) group versus 81.5%, 67.4% and 53.7% in the RLN-LN(+) group, with a significant difference between two group (HR=2.975,95% CI:1.918-4.614, P＜0.01). Conclusions: The lymph node metastasis along RLNs was significantly correlated with primary tumor locations, tumor invasion depth, tumor differentiation, metastasis in the LNs of other stations, and indicate poor prognosis in ESCC.
The Association of Food Insecurity and Cardiometabolic Risk Factors May Be Independent of Body Mass Index
Authors: Hashemzadeh Maral , Teymouri Maryam , Fararouei Mohammad , Barati-Boldaji Reza , Akhlaghi Masoumeh 
Published: October 2021

Abstract
Background: Investigations on food insecurity have shown that food insecurity is negatively associated with health. We examined the association of food insecurity, cardiometabolic risk factors, and dietary patterns in women. Methods: The cross-sectional study was performed on 190 females referred to primary health care centers in Shiraz, Iran. Food insecurity was assessed by Household Food Insecurity Access Scale. Cardiometabolic risk factors including anthropometric characteristics, blood pressure, and serum glucose and lipids were measured. Diet was assessed with a semi-quantitative food frequency questionnaire. Results: Cardiometabolic risk factors increased across food insecurity levels (P<0.001 to 0.009). Two healthy and 1 unhealthy dietary patterns were extracted. Food insecure participants consumed less meats, dairy, fruit, and vegetables but more processed meats (P<0.001). Intake of fat, cholesterol, and sodium increased and that of fiber, vitamins A and C, folic acid, potassium, and calcium decreased along with increasing food insecurity. Food secure individuals had better eating habits than food insecure participants. Cardiometabolic risk factors except triglycerides had inverse associations with heathy and positive associations with unhealthy dietary patterns (P<0.05). The associations between food insecurity and cardiometabolic risk factors were independent of age, sex, education level, and body mass index (BMI).Conclusions: Overall, food insecurity was associated with increased cardiometabolic risk and less healthier dietary patterns. The association between food insecurity and cardiometabolic risk was independent of demographic factors and BMI, suggesting that other factors such as diet and eating habits may have contributed to the exacerbated cardiometabolic risk factors in food insecure individuals.
Evaluating The Temporal Relationship Between Climatic and Demographic Events Using Radiocarbon Data: A Case-Study From The Chulmun Period, Korea
Authors: Kim Habeom , Lee Gyoung-Ah , Crema Enrico Ryunosuke 
Published: October 2021

Abstract
We investigate the relationship between climatic and demographic events in Korea during the Chulmun period (10,000–3,500 cal. BP) by analyzing paleoenvironmental proxies and 14C dates. We focus on testing whether a cooling climate, and its potential impact on millet productivity around 4,500 cal. BP triggered the population decline observed in the archaeological record. We employ a Bayesian approach that measures the temporal relationship between climatic events and change-points in the rate of growth in human population as inferred by radiocarbon density. Our results do not support the climate-induced population decline hypothesis for three reasons. First, we could not determine that the cooling climatic event necessarily preceded the reversal point in population growth rate as inferred by the radiocarbon record. Second, we did not find evidence showing a significant reduction of millet-associated dates occurring during the cooling climate. Third, we detected a spatially differentiated pattern of decline in inland and coastal regions, indicating that the cooling climate did not impact all populations equally. We highlighted the long tradition of mobility-based subsistence strategy in the coastal region as a potential factor contributing to the spatial differences.
The Association Between Neutrophil-Lymphocyte Ratio and Poor Outcomes Following Infant Cardiac Surgery
Authors: Gao Peng , Liu Jinping , Wang Xu , Zhang Peiyao , Jin Yu , Bai Liting , Li Yixuan 
Published: October 2021

Abstract
Background: Neutrophil-lymphocyte ratio (NLR) is a valuable indicator for evaluating inflammation and adverse outcomes after cardiac surgery. The objective of this study was to evaluate the association of perioperative NLR with clinical outcomes in infants undergoing congenital heart surgery with cardiopulmonary bypass.Methods: We performed a retrospective review of 424 consecutive infants (≤ 1 year) undergoing cardiac surgery between January 2019 and September 2019. Neonates (≤ 28 days) and patients with incomplete NLR data were excluded. The study endpoint was a composite of poor outcomes after surgery. We assess the correlation between perioperative NLR and clinical outcomes. A receiver operating characteristic curve and multivariable logistic regression were applied to identify the prognosis performance of postoperative NLR for poor outcomes.Results: A total of 68 (16%) infants experienced at least one of the poor outcomes. Postoperative NLR on the third day after the surgery showed the best prognostic significance (AUC = 0.763, 95%CI 0.700-0.826) among perioperative period, with a cut-off value of 2.05. Postoperative NLR was also strongly correlated with mechanical ventilation time, length of ICU and hospital stay (p < 0.001). Multivariable logistic regression revealed that elevated postoperative NLR (OR 3.722, 95%CI 1.895-7.309, p < 0.001) was an independent risk factor for poor outcomes in infants after cardiac surgery.Conclusions: Postoperative NLR was correlated with increased mechanical ventilation time, length of ICU and hospital stay. Elevated postoperative NLR was an independent predictor for poor outcomes after cardiac surgery in infants.
WITHDRAWN: Particle Nature of Photons, Straight Diffraction Pattern and Curved Diffraction Pattern Emerging in Same Grating Experiment
Authors: Peng Hui 
Published: October 2021

Abstract

The particle nature of the photons was experimentally confirmed. The static straight line diffraction pattern of the normal grating experiments has been shown experimentally. The phenomenon of the dynamic curved diffraction pattern of the grating experiment have been shown in separate experiments. In this article, the new experiments are proposed and performed, which show that the particle nature of the photons, the static straight line diffraction patterns, and the dynamic curved, expanded and inclined diffraction patterns co-exist in the same grating experiment simultaneously. The novel phenomena make the Feynman’s mystery of the normal double slit experiment more mysterious, violate Bohr’s complementarity principle, and provide comprehensive information/data for studying the wave-particle duality and developing new theoretical model.
Cross-sectional Study of Cholinergic Urticaria Subtypes and Bronchial Hyperresponsiveness
Authors: Katsurada Naoko , Nagano Tatsuya , Yamamoto Masatsugu , Kiriu Tatsunori , Dokuni Ryota , Kamiryo Hiroshi , Yoshioka Ai , Fukunaga Atsushi , Nishigori Chikako , Nishimura Yoshihiro , Kobayashi Kazuyuki 
Published: October 2021

Abstract
BackgroundCholinergic urticaria (CholU) is classified into several subtypes: 1) conventional sweat allergy-type CholU (conventional SAT-CholU), 2) CholU with palpebral angioedema (CholU-PA), 3) CholU with acquired anhidrosis and/or hypohidrosis (CholU-Anhd), and other rare type; 1) and 2) include SAT based on pathogenesis. There have been no studies on differences in the prevalence of bronchial asthma among the CholU subtypes. This is investigated in the present study by evaluating the bronchial responsiveness of each subtype.MethodsPatients 16–80 years of age with CholU were enrolled. We analyzed bronchial responsiveness, respiratory symptoms, and exhaled nitric oxide (FeNO). Bronchial responsiveness was assessed using the methacholine dose indicator Dmin.ResultsA total of 11 patients with conventional SAT-CholU, 11 with CholU-PA, and 11 with CholU-Anhd were enrolled. Median log10 Dmin (interquartile range) of patients with conventional SAT-CholU, CholU-PA, and CholU-Anhd was 0.381 (−0.829, 1.079), 0.717 (0.249, 0.787), and 1.318 (0.121, 1.699), respectively (p=0.516). Dmin was lower in patients with SAT (conventional SAT-CholU and CholU-PA) than in those with CholU-Anhd, although the differences among the 3 types were not significant. Respiratory symptoms evaluated using the International Primary Care Airways Group questionnaire were less frequently observed in CholU-Anhd (0 [0, 1]) than in conventional SAT-CholU (1 [0–2]) or CholU-PA (1 [1–3]) (p=0.049). FeNO of patients with conventional SAT-CholU, CholU-PA, and CholU-Anhd was 23 (18.5, 65.0), 39 (32.0, 59.5), and 25 (19.0, 33.0) ppb, respectively (p=0.237). One of 11 conventional SAT-CholU patients (9.1%) and 6 of 11 CholU-PA patients (54.5%) required treatment for bronchial asthma.ConclusionsLog Dmin tended to be lower in patients with SAT-CholU than in those with CholU-Anhd. Distinguishing between CholU subtypes may reveal different degrees of bronchial responsiveness based on a distinct pathogenesis.Trial registration numberUMIN 000025669; https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000027550
Advanced Copper and Copper Alternatives for Crop Protection -
A Mini-Review
Authors: Pereira Jorge , King Alex , Campos Maria Gabriela Nogueira , Santra Swadeshmukul 
Published: October 2021

Abstract:
Copper (Cu) has been used in agriculture for centuries as a standard bactericide/fungicide
due to its low cost, superior disease control efficacy, and relatively low toxicity to humans. However,
the extensive use of copper as a pesticide has caused the development of Cu-tolerant microorganisms
as well as negative environmental impacts due to the accumulation of copper in soil and bodies of
water. Therefore, there is a strong demand for advanced Cu products and alternatives to minimize the
Cu footprint in the environment. This minireview will cover the limitations of Cu usage and the
strategies being investigated to develop advanced Cu materials and alternatives for crop protection
using nanotechnology.
Foreign Body Extraction of a Push-pin nail with Granulation Tissue Complication on a Thirteen Years Old Male
Authors: Octavia Umi fatma , Putra Ngakan Putu Parsama 
Published: October 2021

Background : Foreign body aspiration is common in children (80% in children under 5 years old) and elderly. The ratio in men is higher than in women. Flexible bronchoscopy is often used as a primary procedure in such cases because of its high sensitivity and specificity. However, in some cases, rigid bronchoscopy might be superior. This is a case report about a patient who came with complaints of bloody cough and chest pain after the ingestion of a push-pin nail. The patient underwent both bronchoscopic procedures.Case : A 13-year-old male presented with complaints of sudden bloody coughing accompanied by chest pain in the middle area. Physical examinations were unremarkable, but images of spikes suggestive of a foreign object on the left hilus were found at the chest x-ray. A flexible fiberoptic bronchoscopy was performed immediately. A push-pin nail, located the left main bronchus with a sharp tip embedded in the mucosa and covered by granulation tissue, was identified. Evacuation attempts were unsuccessful. Rigid bronchoscopy was then performed and evacuation was carried out successfully. The patient was then discharged after forty-eight hours of close monitoring.Conclusion: There are two types of bronchoscopy, flexible and rigid. Both have their respective advantages in the handling of patients with foreign bodies. Â Acquiring skills in operating both types of bronchoscopy are important for a bronchologist.Keywords: Foreign body, Aspiration, Granulation tissue, Bronchoscopy