bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Modification of Phage‐Displayed Helix‐Loop‐Helix Peptides to Construct Kinase‐Focused Libraries
Authors: Fujiwara Daisuke , Mihara Kousuke , Takayama Ryo , Nakamura Yusuke , Ueda Mitsuhiro , Tsumuraya Takeshi , Fujii Ikuo 
Published: October 2021

AbstractConformationally constrained peptides hold promise as molecular tools in chemical biology and as a new modality in drug discovery. The construction and screening of a target‐focused library could be a promising approach for the generation of de novo ligands or inhibitors against target proteins. Here, we have prepared a protein kinase‐focused library by chemically modifying helix‐loop‐helix (HLH) peptides displayed on phage and subsequently tethered to adenosine. The library was screened against aurora kinase A (AurA). The selected HLH peptide Bip‐3 retained the α‐helical structure and bound to AurA with a KD value of 13.7 μM. Bip‐3 and the adenosine‐tethered peptide Bip‐3‐Adc provided IC50 values of 103 μM and 7.7 μM, respectively, suggesting that Bip‐3‐Adc bivalently inhibited AurA. In addition, the selectivity of Bip‐3‐Adc to several protein kinases was tested, and was highest against AurA. These results demonstrate that chemical modification can enable the construction of a kinase‐focused library of phage‐displayed HLH peptides.
Metal‐Organic Frameworks with Novel Catenane‐like Interlocking: Metal‐Determined Photoresponse and Uranyl Sensing
Authors: Guo Meng‐Yue , Li Gen , Yang Shuai‐Liang , Bu Ran , Piao Xian‐Qing , Gao En‐Qing 
Published: October 2021

AbstractThe assembly of two tripyridinium‐tricarboxylate ligands and different metal ions leads to seven isostructural MOFs, which show novel 2D→2D supramolecular entanglement featuring catenane‐like interlocking of tricyclic cages. The MOFs show tripyridinium‐afforded and metal‐modulated photoresponsive properties. The MOFs with d10 metal centers (1‐Cd, 1‐Zn, 2‐Cd, 2‐Zn) show fast and reversible photochromism and concomitant fluorescence quenching, 1‐Ni displays slower photochromism but does not fluoresce, and 1‐Co and 2‐Co are neither photochromic nor fluorescent. It is shown here that the network entanglement dictates donor‐acceptor close contacts, which enable fluorescence originated from interligand charge transfer. The contacts also allow photoinduced electron transfer, which underlies photochromism and concomitant fluorescence response. The metal dependence in fluorescence and photochromism can be related to energy transfer through metal‐centered d‐d transitions. In addition, 1‐Cd is demonstrated to be a potential fluorescence sensor for sensitive and selective detection of UO22+ in water.
Luminescent Chiral Exciplexes with Sky‐Blue and Green Circularly Polarized‐Thermally Activated Delayed Fluorescence
Authors: Sumsalee Patthira , Abella Laura , Kasemthaveechok Sitthichok , Vanthuyne Nicolas , Cordier Marie , Pieters Grégory , Autschbach Jochen , Crassous Jeanne , Favereau Ludovic 
Published: October 2021

AbstractLuminescent exciplexes based on a chiral electron donor and achiral acceptors are reported as a new approach to design circularly polarized (CP) and thermally activated delayed fluorescence (TADF) emitters. This strategy results in rather high CP luminescence (CPL) values with glum up to 7×10−3, one order of magnitude higher in comparison to the CPL signal recorded for the chiral donor alone (glum ∼7×10−4). This increase occurs concomitantly with a CPL sign inversion, as a result of the strong charge‐transfer emission character, as experimentally and theoretically rationalized by using a covalent chiral donor‐acceptor model. Interestingly, blue, green‐yellow and red chiral luminescent exciplexes can be obtained by modifying with the electron accepting character of the achiral unit while keeping the same chiral donor unit. These results bring new (inter)molecular guidelines to obtain simply and efficiently multi‐color CP‐TADF emitters.
Endohedral Metallofullerenes: An Ideal Platform of Sub‐Nano Chemistry
Authors: Shen Wangqiang , Bao Lipiao , Lu Xing 
Published: October 2021

Comprehensive SummaryThe hollow cavity of fullerenes is an ideal host for the stabilization of a variety of otherwise unstable metallic clusters, enabling the discovery of novel compounds and unconventional metal‐metal and metal‐carbon interactions. Meanwhile, the internal metallic species exert interesting influences on the chemical properties of the cage carbons, mainly through electronic interactions, leading to unexpectedly high regioselectivity and high yield, and even quantitative conversion.
What is the most favorite and original chemistry developed in your research group?Creation of novel metal‐carbon hybrid molecules with unconventional techniques, known as endohedral metallofullerenes, and the unexplored chemistry hidden inside them, especially discovery of the unprecedented bonding between rare earth metal ions and a variety of novel metal clusters, e.g., Ti3C3 and Dy2N4.How do you get into this specific field? Could you please share some experiences with our readers?I entered the field of fullerenes when I was pursuing my Ph.D. during 2001—2004 in Peking University. At that time, fullerenes are no longer a hot research subject as carbon nanotubes which have shown huge perspectives in both fundamentals and applications. However, I like fullerenes because of their clear structures and readily high solubility in organic solvents, which are rather attractive to chemists. I have been working in this field for nearly twenty years and my feeling is that interest and passion are the most important characteristics for a scientist to keep finding in a seemingly out‐of‐date field.What are your hobbies? What are your favorite books?Badminton is my favorite sport in addition to jogging, and reading historical novels and essays is a hobby during my leisure time. Myfavorite books are “Romance of the Three Kindoms”, “War and Peace”, “A Dream of Red Mansions” and “One Hundred Years of Solitude”.How do you supervise your students?As every student has his/her own talents so that I treat each as individuals to express their own merits as much as possible. In addition, the graduate students in my lab do not only learn about the detailed experimental skills but also the way how to find solutions to the scientific problems they are facing, namely thinking modes to solve problems. In detail, I request my students to ensure their time and energy in experiments and research works daily, as diligence is the magic weapon of success, in addition to persistence and enthusiasm.How do you keep balance between research and family?My motivation of hard‐working comes from my family so that I concentrate on my work during working time every day, but I try my best to stay with my kids on weekends and leisure time to replenish my energy.Could you please give us some advices on improving Chinese Journal of Chemistry?This journal should cover all categories of chemistry, keeping balance among organic, inorganic, materials, analytical and others, instead of focusing too much on organic and synthetic chemistry.
The association of interferon‐alpha with development of collateral circulation after artery occlusion
Authors: Xing Zhenhua , Wang Xiaopu , Pei Junyu , Zhu Zhaowei , Tai Shi , Hu Xinqun 
Published: October 2021

AbstractBackgroundPrevious studies have demonstrated that interferon (IFN) signaling is enhanced in patients with poor collateral circulation (CC). However, the role and mechanisms of IFN‐alpha in the development of CC remain unknown.MethodsWe studied the serum levels of IFN‐alpha and coronary CC in a case–control study using logistics regression, including 114 coronary chronic total occlusion (CTO) patients with good coronary CC and 94 CTO patients with poor coronary CC. Restricted cubic splines was used to flexibly model the association of the levels of IFN‐alpha with the incidence of good CC perfusion restoration after systemic treatment with IFN‐alpha was assessed in a mice hind‐limb ischemia model.ResultsCompared with the first IFN‐alpha tertile, the risk of poor CC was higher in the third IFN‐alpha tertile (OR: 4.79, 95% CI: 2.22–10.4, p < .001). A cubic spline‐smoothing curve showed that the risk of poor CC increased with increasing levels of serum IFN‐alpha. IFN‐alpha inhibited the development of CC in a hindlimb ischemia model. Arterioles of CC in the IFN‐alpha group were smaller in diameter than in the control group.ConclusionPatients with CTO and with poor CC have higher serum levels of IFN‐alpha than CTO patients with good CC. IFN‐alpha might impair the development of CC after artery occlusion.
A traffic‐centric fuzzy approach for solving the starvation problem of cooperative awareness messages in vehicular ad hoc networks
Authors: Abdollah Sepideh , Zarei Mani 
Published: October 2021

SummaryCongestion problem in vehicular ad hoc networks (VANETs) is one of the main factors that negatively affect the inter‐vehicle communication (IVC) efficiency of such emerging networks. Decentralized congestion control (DCC) is an effective method for overcoming the congestion problem. However, lower priority packets such as cooperative awareness messages (CAMs) may be encountered with the starvation problem in the DCC approach. This paper proposes FDCC: a traffic‐centric Fuzzy DCC approach for improving CAMs delivery ratio, especially in congested traffic flows. FDDC architecture consists of four fuzzy inference systems (FISs). The inter‐vehicle distance (IVD) and the speed variation are the spatiotemporal fuzzy inputs, which are customized for both single direction and multi‐direction scenarios. Based on the FIS outputs, the FDCC control system, unlike the DCC, provides a way for processing starved CAMs by ignoring unnecessary even‐driven messages. The obtained simulation results through OMNET++ in both single and multi‐direction scenarios show the efficiency of FDCC in terms of the end‐to‐end delay, network throughput, and packet delivery ratio for event‐driven messages as well as essential CAMs.
G protein‐coupled receptor GPR37‐like 1 regulates adult oligodendrocyte generation
Authors: An Jing , Zhang Yumeng , Fudge Alexander D. , Lu Haixia , Richardson William D. , Li Huiliang 
Published: October 2021

AbstractOligodendrocytes (OLs) continue to be generated from OL precursors (OPs) in the adult mammalian brain. Adult‐born OLs are believed to contribute to neural plasticity, learning and memory through a process of “adaptive myelination,” but how adult OL generation and adaptive myelination are regulated remains unclear. Here, we report that the glia‐specific G protein‐coupled receptor 37‐like 1 (GPR37L1) is expressed in subsets of OPs and newly formed immature OLs in adult mouse brain. We found that OP proliferation and differentiation are inhibited in the corpus callosum of adult Gpr37l1 knockout mice, leading to a reduction in the number of adult‐born OLs. Our data raise the possibility that GPR37L1 is mechanistically involved in adult OL generation and adaptive myelination, and suggest that GPR37L1 might be a useful functional marker of OPs that are committed to OL differentiation.
Determinants of psychosocial factors among the oldest old – Evidence from the representative “Survey on quality of life and subjective well‐being of the very old in North Rhine‐Westphalia (NRW80+)”
Authors: Hajek André , König Hans‐Helmut 
Published: October 2021

AbstractObjectivesOur aim was to examine socioeconomic and health‐related variables associated with psychosocial factors among the oldest old.MethodsCross‐sectional data were used from the representative “Survey on quality of life and subjective well‐being of the very old in North Rhine‐Westphalia (NRW80+)” consisting of individuals aged 80 years and over (n = 952, average age was 86 years) living in North Rhine‐Westphalia (most populous state of Germany). Established tools were used to quantify loneliness, life satisfaction and depressive symptoms. Socioeconomic and health‐related determinants were included in regression analysis.ResultsMultiple linear regressions showed that higher life satisfaction was associated with a greater network size, lower functional impairment and better self‐rated health. Moreover, higher loneliness was associated with being unmarried, a smaller network size, worse self‐rated health and higher functional impairment. Additionally, more depressive symptoms were associated with lower age (i.e., 80–84 years compared to 90 years and over), asset poverty, the presence of multimorbidity, higher functional impairment and worse self‐rated health.ConclusionsOur study identified various socioeconomic and health‐related factors associated with worse psychosocial factors among the oldest old. This knowledge may assist in targeting oldest old individuals at risk for worse psychosocial factors.
Diogenes syndrome in a 10‐year retrospective observational study: An elderly case series in Tokyo
Authors: Ito Kae , Okamura Tsuyoshi , Tsuda Shuji , Awata Shuichi 
Published: October 2021

AbstractObjectivesSupporting people suffering from Diogenes Syndrome (DS) is a challenge for geriatric psychiatry. However, there is a lack of knowledge about DS in Japan. Therefore, a systematic longitudinal study to clarify the factors associated with DS and its prognosis was conducted.Methods/DesignA retrospective study using data from case records of a municipal psychogeriatric service was conducted. The study population was socially isolated older adults with complex mental health and social care needs who had been referred to the service over 10 years. The participants were stratified into DS and non‐DS groups, multivariate analysis was performed to identify factors associated with DS, and survival analysis was performed.ResultsOf the 270 participants, 61 with Environmental Cleanliness and Clutter Scale (ECCS) scores >12 were assigned to the DS group, and 209 with ECCS scores ≤12 were assigned to the non‐DS group. On multiple logistic regression analysis, significantly more people in the DS group were living alone, had advanced dementia, and had reduced basic activities of daily living (BADL) compared to the non‐DS group. Furthermore, survival analysis showed that the DS group had a higher risk of early death than the non‐DS group.ConclusionsIn the present study, social isolation, living alone, advanced dementia, and reduced BADL were found to be associated with DS. In addition, DS had a high risk of early death. Support for DS must take into account not only mental and social health, but also physical health from an early stage.
Successful supportive encounters from the peer supporter's perspective: Do status similarities to support recipients matter?
Authors: Thoits Peggy A. 
Published: October 2021

AbstractExperientially similar others, or “peer supporters,” are persons who have faced a support recipient's stressor before. Theory suggests that peer supporters' understanding of and empathy for support recipients will be heightened when they match recipients not only in stressor experience but on one or more social statuses (e.g., age, education). Thus, peer‐support volunteers may perceive supportive encounters as more successful when participants' statuses match. To explore this, volunteer Mended Hearts Visitors (former heart patients who visit currently hospitalized cardiac patients and their family members) were interviewed in‐depth (N = 84). Visitors more often perceived same age and gender, but not same race and education, as enhancing rapport and patients' receptivity to their help. The findings suggest statuses which are culturally relevant to a shared stressor (here, cardiac surgery) can boost supporters' effectiveness, with practical implications for peer support‐giving organizations that bring together experiential peers with recipients in pairs or small groups.
Putting psychotherapy in its place: The regionalization of behavior therapy in France, Switzerland, and Belgium, 1960s–1990s
Authors: Amouroux Rémy , Gerber Lucie , Aronov Milana 
Published: October 2021

AbstractThis article traces the history of the behavior therapy movement in French‐speaking Europe between the 1960s and the 1990s, focusing on its geographically located development, whether on a national, sub‐ or supra‐national scale. By examining the trajectories of the three main behavioral therapy associations in France, Switzerland, and Belgium, we show that it is not possible to subsume them under a common intellectual history. Despite the importance of theoretical debates in the emergence of this brand of psychotherapy in English‐speaking countries, adherence to this type of explanation falls short of accounting for the differential reception of behavioral therapies in these countries. We argue that the later development of behavioral therapy in France, Belgium, and Switzerland was shaped more by professional agendas, local definitions, and regulations of psychotherapy than by “pure” theoretical commitments and conflicts between schools of thought. From a historiographical perspective, exploring the regionalization of psychotherapeutic styles thus involves contesting the idea that different therapies are mainly characterized by adherence to psychological theories and embedded ontologies of the self that are radically opposed (i.e., humanism vs. naturalism, psychoanalysis vs. behavior therapy). Localizing psychotherapies and paying attention to the varying circumstances and traditions in which they have evolved allows us to go beyond this dichotomous vision and to access a multiplicity of nondogmatic and intermediate positions that would otherwise be invisible.
Microwave‐assisted diversified synthesis of pyrimidines: An overview
Authors: Kumar Kapil 
Published: October 2021

AbstractPyrimidines and their hybrid molecules have continued to be a favorable area for organic chemists owing to their richness in natural and synthetic compounds with multifarious involvement in pharmaceuticals and polymers and act as ligands. Different novel and greener synthetic protocols were developed in the last decades, but microwave‐assisted synthetic protocols played a significant role in constructing pyrimidine and its derivatives. In this article, we summarized the microwave‐supported strategy for the construction of pyrimidine fused or linked/tethered with other heterocycles, polysubstituted pyrimidines, solid‐supported synthesis of pyrimidines, and ionic liquid‐catalyzed strategies for the synthesis of pyrimidine and its derivatives reported in the last decade. Solid‐supported protocols using resins and ionic liquid‐catalyzed strategies afforded the corresponding products with excellent yield by dual activation. In most of the reports, the microwave‐irradiated approach was compared with conventional/traditional heating and found better in terms of reaction time, yield, atom economy, adherence with green chemistry principles, and reduction in purification wastage. Various authors evaluated the in vitro potential of synthesized pyrimidine derivatives for antimicrobial and antimalarial potential, and found moderate to excellent biological activity.
Tropical cyclones over the Arabian Sea during the monsoon onset phase
Authors: Dhavale Shreyas , Mujumdar Milind , Roxy Mathew Koll , Singh Vineet Kumar 
Published: October 2021

AbstractGenerally, monsoon conditions are unfavourable for cyclogenesis in the Arabian Sea due to the strong vertical wind shear present over the basin which prevents the vertical development of cyclones. However, there are instances where tropical cyclones form over the basin during the onset phase of the Indian summer monsoon (ISM). The current study examines the evolution of the synoptic conditions in the years during 1979–2019 in which a cyclone forms during the onset phase of the ISM. The effect of various atmospheric and oceanic factors, the modulation of wind circulation over the Indian subcontinent and the north Indian Ocean region due to the possible influence of tropical and extratropical weather systems has been taken into consideration. Our analysis indicates that a weak mean monsoonal wind circulation caused by the southward intrusion of subtropical westerlies (at 200 hPa) is conducive for cyclogenesis over the Arabian Sea during the monsoon onset phase. Such a weak onset phase of the monsoon, coupled with the seasonal warm SSTs, may lead to cyclone formation in the Arabian Sea.
Low‐cost and fast‐performing indicators of muscle mass loss are good predictors of clinical outcomes in hospitalized patients: A longitudinal observational study
Authors: dos Santos RD Carolina Oliveira , Burgel Camila Ferri , Chites RD Victoria Silva , Lima RD Júlia , Silva PhD Flávia Moraes 
Published: October 2021

AbstractBackground“Gold standard” methods for muscle mass (MM) assessment are expensive and difficult to use in clinical practice. The present study aimed to evaluate the association between easy‐to‐apply and low‐cost indicators of MM and clinical outcomes in hospitalized patients.MethodsIn this cohort study, calf circumference [CC], adductor pollicis muscle thickness [APMT], midarm muscle circumference [MAMC], and arm muscle area [AMA] were measured within 48 h of admission to detect MM loss, and it was also evaluated by physical examination. Patients were followed up until discharge for collection of in‐hospital death and length of hospital stay (LOS) data, and they were contacted by phone to assess hospital readmission and mortality at 6 months after discharge.ResultsWe evaluated 601 patients (55.8 ± 14.8 years). Moderate/severe loss of MM (hazard ratio [HR], 4.12; 95% CI, 1.26–13.49), low CC (HR, 3.67; 95% CI: 1.07–12.55), low MAMC (HR, 5.20; 95% CI, 1.48–18.35), and low AMA (HR, 14.28; 95% CI, 1.80–113.14) were predictors of in‐hospital mortality. Moderate/severe loss of MM was a predictor of prolonged LOS (odds ratio [OR], 2.27; 95% CI, 1.53–3.36), hospital readmission (OR, 4.14; 95% CI, 1.26–13.55), and mortality at 6 months (OR, 3.20; 95% CI, 1.71–6.01). Low CC (OR, 2.49; 95% CI, 1.27–4.85) and low APMT (OR, 3.22; 95% CI, 1.56–6.66) were associated with death 6 months after discharge.ConclusionEasy‐to‐apply and low‐cost indicators of MM were associated with negative clinical outcomes and should be part of nutrition assessment in hospitals
Omitting routine gastric residual checks may help to accelerate enteral feeds and postnatal growth in stable preterm infants
Authors: Terek Demet , Celik Mahmut , Ergin Firat , Erol Elif , Altun Koroglu Ozge , Yalaz Mehmet , Akisu Mete , Kultursay Nilgun 
Published: October 2021

AbstractBackgroundThe prefeed gastric residual check (GRC) when increasing the amounts of feeds given via orogastric and nasogastric tubes as a precaution for necrotizing enterocolitis (NEC) and intestinal intolerance is a routine procedure. However, it is mostly misleading, and recently, there has been a tendency not to check prefeed residuals.MethodsWe changed our nutrition protocol at the end of 2018 to start minimal enteral feeds (MEFs) and increase feeds without GRCs. We investigated the effects on the incidence of NEC, complications, time to reach full feeds, and growth parametersResultsWe compared the results of 60 preterm infants at ≤35 weeks’ gestational age (group 1: 2016–2017, cared for with GRC) and 77 preterm infants (group 2: 2019, without routine GRCs). No differences in incidence of NEC and complications were observed. Group 2 started enteral feeds 3 days earlier, reached total feeds 6 days earlier (P < 0.01), and had higher weight (P < 0.01) and head circumference gain (P < 0.01). Extrauterine growth restriction was significantly less for head circumference and also insignificantly less for weight and height.ConclusionWe conclude that starting MEFs earlier and omitting routine GRCs in clinically stable preterm infants accelerate enteral feeds and growth parameters.