bluuebunny/crossref_metadata_2025_split huggingface dataset:
2. Glucose levels of Canis familiaris Urine in Lamposi Tigo Nagori Payakumbuh Using Semiquantitative Striptest
Authors: Amalia Fhatania , Roslizawaty Roslizawaty , Rusli Rusli , Sayuti Arman , Hasan M , Amiruddin Amiruddin , Zuraida Zuraida 
Published: September 2021

The aim of this study was to detect the glucose in urine of Canis familiaris as a medical record and a supporting early diagnostic. Urine of thirty local dogs collected from Lamposi Tigo Nagori, Sumatera Barat. Before feeding, urine was collected individually in the morning two times. This study was doing on January 2016. The strip test was soaked in urine (5-10 ml) for 30 second directly. Data of glucose was analyzed using 4 scale discoloration of semi quantitative striptest. The result showed that glucose was not detected on 25 dogs out of 30 of C. familiaris. Amount of 5 C. familiaris were detected the presence of glucose with small (100 mg/dl) scale. We concluded that the levels of glucose C. familiaris urine performed on the tolerance limits of glucose level.
4. The Value of Erythrocytes, Hemoglobin, and Hematocrit of Mice (Mus musculus) Exposed to Cigarette Smoke and Given Red Watermelon Extract (Citrullus vulgaris)
Authors: Heryanita Yola , Rusli Rusli , Rosmaidar Rosmaidar , Zuraidawati Zuraidawati , Rinidar Rinidar , Asmilia Nuzul , Jalaluddin Muhammad 
Published: September 2021

The aim of this research was to investigate the effect of red watermelon (Citrullus vulgaris) extract to the value of erythrocytes, hemoglobin, and hematocrit of mice (Mus muscullus) exposed to cigarette smoke. This study followed direct complete randomized design by using 12 males’ mice which divided into 4 groups. The treatment group is divided by the negative control group which given 0,5 ml of aquadest, the positive control group which exposed to cigarette smoke and 0,5 ml of aquadest. The treatment group I was exposed to cigarette smoke and given red watermelon extract dose 22 mg/Bw mice. The treatment group II was exposed to cigarette smoke and given red with watermelon extract dose 44 mg/Bw mice. The exposure to cigarette smoke and the given of red watermelon extract were conducted for 30 days. The blood taking was performed on day 31 in the Plexus retroorbital. Furthermore, the number of erythrocytes, hemoglobin and hematocrit were calculated. The data were analyzed using ANOVA completely randomized design with SPSS for Windows 16.0. The results of this study showed that the extract of red watermelon for 30 days showed a highly significant effect (P 0.01) to the number of erythrocytes, hemoglobin, and hematocrit of mice. It is concluded that free radicals contained in the cigarette can cause a hemoglobin desaturation, increased blood viscosity, oxidative stress and red watermelon extract can minimize the damage.
16. The Effect of Indigofera sp. Leaf on the Protein Level of Rabbit Meat (Orictolagus sp)
Authors: Iqwal Yuza Al , Rastina Rastina , Harris Abdul , Ferasyi T. Reza , Azhar Al , Akmal Muslim 
Published: September 2021

This study aimed to determine the effect of Indigofera sp. leaf to increase protein content of rabbit meat (Origtolagus sp). This study used a complete randomized design, consisted of 3 treatments and 3 replications. The samples were nine local male rabbits aged two months. P0 was control group which was given commercial feed, P1 was given 80% commercial feed and 20% Indigofera sp. pellet leaf, and P2 was given 70% commercial feed and 30% Indigofera sp. pellet leaf. The feeding and drinking was conducted at 07:00 to 08:00 am and at 04:00 to 05:00 pm ad libitum. Protein content was measured using Kjeldahl method after eight weeks of treatments. The data was analyzed using Analysis of Variance (ANOVA) with SPSS v16.0 for Windows. The results showed that mean value (±SD) of meat protein for P0, P1 and P2 were 18.79+0.81%, 19.40+0.33% and 20.88+0.74%, respectively. We can conclude that the leaves of Indigofera sp. was highly significant (P0,01) in increasing protein level of rabbit meat at a concentration of 30%.
18. The Effect of Sipatah-Patah (Cissus quadrangularis Salisb) Extract on Mandible Density of Ovariectomized Rats (Rattus norvegicus)
Authors: Maghfirah Indah , Jalaluddin Muhammad , Masyitha Dian , Sabri Mustafa , Gani Fadli A , Herrialfian Herrialfian 
Published: September 2021

The aim of this research was to identify the effect of sipatah-patah (Cissus quadrangularis Salisb) leaf extract on mandible density of ovariectomized rats (Rattus norvegicus). The samples were 12 female rats which were divided into 4 treatment groups with 3 replications. K0 consisted of ovariectomized rats without Cissus quadrangularis Salisb exstract, wheares K1, K2 and K3 consisted of ovariectomized rats and were given Sipatah-patah extract with 500mg/kg body weight, 700/mg/kg body weight and 900mg/kg body weight for 30 days. On 31st day, rats were euthanized with cloroform and mandible bones were collected for histological preparation. Parameters observed were bone structures (osteosit, osteoblast, osteoclast and trabekula). The results showed that in K0 group, bone density was decreased and became thinner, osteoclast cells were found on trabekula, and low density of active and passive osteoblast were also detected. The treatment group (K1 and K2) showed an improvement stucture of trabekula,where the amount of osteoclast were lower than K0, as well as the amount of active osteoblast, although a lot of passive osteoblast were still found. The treatment group (K3) showed an improvement as the most dense trabekula structure with large amount of active osteoblast cell density without the existance of osteoclast compared to other grups. In this research, it would be concluded that the adding sipatah-patah extract with a dose of 900 mg/kb body weight showed a higher number of active osteoblasts and trabekula density compared to the control groups, K1, and K2 on ovariectomized mandible bone rats
33. Efficacy of Jatropha(Jatrophacurcas L.) Sap Cream in Inflammation Phase of Wound Healing on Mice Skin
Authors: Hidayati Hidayati , Salim Muhammad Nur , Balqis Ummu , Masyitha Dian , Iskandar Cut Dahlia , Darmawi Darmawi , Harris Abdul 
Published: September 2021

This study aim to know the efficacy of the jatropha sap cream toward the inflammatory phase of wound healing on the skin of mice. This study used 9 male mice, with 25-40 grams weights and 2-3 months old. Male mice receiveddivided into 3 groups, and3 deuteronomy.The cut is done in the back as 2 cm long. Wound care is done twice a day at 08.00 am and at 18.00 pm for 3 days. The treatment I (PI) cuts smeared a cream base (as a negatif control); treatment II (PII) smeared 10% jatropha sap cream; and the treatment III (PIII) smeared 0.1% sulfadiazine (as a positive control).Created a skin sample preparation microtechnic stained with hematoxylin-eosin (HE). The result on the number of infiltration of inflammatory cells and neovascular on PI; PII; and PIII were 402,00 ± 7,21 and 14,00 ± 5,57; 248,67 ± 1,53 and 34,67 ± 7,51; and 343,00 ± 8,89 and 28,00 ± 5,00 (P0,01). Based on the result it be concluded the treatment of 10% jatropha sap cream can speed up the process of the inflammatory phase of wound healing in the skin of mice.
Exclusion Criteria of Breast Cancer Clinical Trial Protocols: A Descriptive Analysis
Authors: Wan Clara , Caston Nicole E. , Ingram Stacey A. , Rocque Gabrielle B. 
Published: September 2021

Abstract
Purpose: 3-8% of US adults with cancer are enrolled in a clinical trial due to various barriers to enrollment. The purpose of this study is to evaluate the variability of eligibility criteria, which currently have no standard guidelines.Methods: This descriptive analysis utilized all therapeutic breast protocols offered at the University of Alabama at Birmingham between 2004-2020. Exclusion criteria were abstracted using OnCore and ClinicalTrials.gov. Laboratory values included liver function tests and hematologic labs. Comorbid conditions included congestive heart failure, cardiovascular disease, central nervous system (CNS) metastases, and prior cancer history. Comorbid conditions were further analyzed by amount of time protocols required participants to be from diagnosis or exacerbation-free.Results: 102 protocols were eligible. Among liver laboratory values, bilirubin (78%) was included in most protocols ranging from institutional upper limit of normal (ULN) (9%) to 3xULN (2%), with 1.5xULN (56%) being most common. Similar variability was observed in alanine transaminase and aspartate transaminase. Among hematological labs, 82% of protocols defined a lower limit of acceptable absolute neutrophil count ranging from 500μL (1%) to 1,800μL (1%), with 1,500μL (64%) being most common. Of the comorbid conditions, exclusion criteria varied for congestive heart failure (49%), an acute exacerbation of cardiovascular disease (80%), CNS metastases (59%) and a prior cancer (66%). The allowable timeframe varied between protocols for cardiovascular disease and prior cancer.Conclusion: Substantial heterogeneity was observed across laboratory values and comorbid variables among protocols. Future research should focus on defining standardized eligibility criteria while allowing for deviation based on drug specificity.
Liver Transplantation in Children and Impact of Intra-operative Goal Directed Therapies on Postoperative Outcome
Authors: Kumba Claudine 
Published: September 2021

Abstract
Background: Liver transplantation is a hemorrhagic surgery with high postoperative complication rates in terms of organ dysfunction and infections. We conducted a retrospective observational monocentric study that had the objectives of determining predictors of postoperative outcome in children. In the initial cohort, 19 children underwent liver transplantation. A description of the postoperative outcomes of these patients was undertaken.Objective: To describe intraoperative and postoperative outcomes in children undergoing liver transplantation and to propose intraoperative management implementation measures for postoperative outcome improvement.Methods: Secondary analysis of liver transplanted patients included in the initial study.Results: There were 19 patients who underwent liver transplantation with a median age of 31[2-154] months. Five patients had re-operations (26.3%). Fourteen (73.7%) had intraoperative and/or postoperative complications. Five (26.3%) had intraoperative hemorrhagic shock. One (5.3%) had postoperative respiratory failure, one (5.3%) had postoperative multiple organ failure, two (10.5%) had postoperative neurologic failure and five (26.3%) had cardio-circulatory failure. One (5.3%) had postoperative pulmonary sepsis, five (26.3%) had postoperative abdominal sepsis, and six (31.6%) had postoperative septicemia. Intra-operative transfusion rate was 100%. In-hospital mortality rate was 10.5% (two patients).Conclusion: There were multiple postoperative adverse outcome predictors. Optimal intraoperative patient management with transfusion guided by point-of-care viscoelastic devices and goal-directed fluid and hemodynamic therapy with validated parameters and tools in children is a possible pathway to upgrade postoperative evolution in pediatric liver transplantation.
Neuroinflammatory Cytokine Response, Neuronal Death and Microglial Proliferation in the Hippocampus of Rats During the Early Period After Lateral Fluid-Percussion-Induced Traumatic Injury of the Neocortex
Authors: Komoltsev Ilia G. , Tretyakova Liya V. , Frankevich Stepan O. , Shirobokova Natalia I. , Volkova Aleksandra A. , Butuzov Alexey V. , Novikova Margarita R. , Kvichansky Alexey A. , Moiseeva Yulia V. , Onufriev Mikhail V. , Bolshakov Alexey P. , Gulyaeva Natalia 
Published: September 2021

Abstract
Time course of changes in neuroinflammatory processes in the dorsal and ventral hippocampus was studied during the early period after lateral fluid-percussion-induced neocortical traumatic brain injury (TBI) in the ipsilateral and contralateral hemispheres. In the ipsilateral hippocampus, neuroinflammation (increase in expression of pro-inflammatory cytokines) was evident from day 1 after TBI and ceased by day 14, while in the contralateral hippocampus it was mainly limited to the dorsal part on day 1. TBI induced an increase in hippocampal corticosterone level on day 3 bilaterally and an accumulation of Il1b on day 1 in the ipsilateral hippocampus. Activation of microglia was observed from day 7 in different hippocampal areas of both hemispheres. Neuronal cell loss was detected in the ipsilateral dentate gyrus on day 3 and extended to the contralateral hippocampus by day 7 after TBI. The data suggest that TBI results in distant hippocampal damage (delayed neurodegeneration in the dentate gyrus and microglia proliferation in both the ipsilateral and contralateral hippocampus), the time course of this damage being different from that of the neuroinflammatory response.
A Dissection of the Topographic Effects from Eurasia and North America on the Isentropic Meridional Mass Circulation in Northern Winter
Authors: Yu Yueyue , Ren Rongcai , Xia Xin , Liang Ruxue , Rao Jian 
Published: September 2021

Abstract
The topographic dynamical effect from Eurasia (EA_Topo) and North America (NA_Topo) on the winter isentropic meridional mass circulation (IMMC) is investigated using the WACCM. The independent effect of EA_Topo and that of NA_Topo, with the former much stronger, are both to strengthen the IMMC that is composed of the lower equatorward cold air branch (CB) and the upper poleward warm air branch in the extratropical tropopshere (WB_TR) and stratosphere (WB_ST). Further investigation of the individual contributions from changes in stationary vs. transient and zonal-mean flow vs. waves reveals that, due to the topography-forced mass redistribution, changes in the low-level meridional pressure gradient force a zonal-mean counter-clockwise/ clockwise meridional cell in the southern/northern side of topography. This weakens/strengthens the IMMC south/north of 30°N from the troposphere to lower stratosphere, acting as a dominant contributor to the IMMC changes south of 50°N. Meanwhile, the EA/NA_Topo-forced amplification of stationary waves constructively interacts with those determined by land-sea contrast, making the dominant/minor contributions to the strengthening of CB and WB_TR north of 50°N. The related increase in the upward wave propagation further dominates the WB_ST strengthening in the subpolar region. Meanwhile, transient eddy activities are depressed by EA/NA_Topo along with the weakened background westerly, which partly-offset/dominate-over the contribution from stationary flow in midlatitudes and subpolar region. The coexistence of the other topography (NA/EA_Topo) yields destructive mutual interferrence, which can weaken/offset the independent-EA/NA_Topo-forced meridional mass transport mainly via changing the zonal-mean as well as the downstream wave pattern of mass and meridional wind.
Sustainable Valorization of Olive Pomace Waste to Renewable Biofuels, Biomaterials and Biochemicals Via Pyrolysis Process: Experimental and Numerical Investigation
Authors: Aissaoui Mohamed Hechmi , Trabelsi Aïda Ben Hassen , Bensidhom Gmar , Ceylan Selim , Leahy James.J , Kwapinski Witold 
Published: September 2021

Abstract
This work demonstrates, experimentally and numerically, the potential of Olive Pomace Waste (OPW) to produce renewable biofuels (pyrolytic oil and gas), bio-chemicals (tars as source of bioactive molecules) and bio-fertilizers (chars) through slow pyrolysis. Experimental pyrolysis runs were conducted at 500, 600 and 700°C as final pyrolysis temperature, 15, 20 and 25°C/min as heating rate and 1h as residence time, in a fixed bed pyrolyzer. In the optimum pyrolysis conditions (600°C and 15°C/min), 33 wt.% of oil, 30.00 wt.% of char and 37 wt.% of gas were produced. Recovered pyrolytic oil presents good energy value (HHV between 15.96 and 20.94 MJ/kg) with a great bioactive potential. The released permanent gases show an interesting energy content (LHV up to 11 MJ/Kg) which emphasizes their application in a gas engine to provide renewable electricity in rural olive groves area. The recovered OPW biochar presents a high carbon (C 72.54 wt.%) and nutrients contents (up to 8.42 mg/g of Ca, up to 8.69 mg/g of K and up to 2.02 % of total N) which make it suitable for soil amendment and for long-term carbon sequestration. Kinetic study of OPW pyrolysis, performed using the Distributed Activation Energy Model (DAEM), gives an activation energy values ranging from 121.6 to 151.6 kJ/mol. The investigation of the OPW thermal behavior and reactivity under pyrolysis conditions is useful approach to design and operate slow pyrolysis process at commercial scale, which could be useful by farmers for OPW in olive fields.
Follicle-stimulating Hormone and Lipid Profile in Women Older than 55
Authors: Zhang Wen , Chen Yingchao , Zhang Xian , Chen Yi , Han Bing , Li Qin , Xia Fangzhen , Zhai Hualing , Wang Ningjian , Lu Yingli 
Published: September 2021

Abstract
Purpose. Follicle stimulating hormone (FSH) is associated with higher risks of metabolic syndrome and diabetes in menopausal women. We aimed to investigate whether FSH was associated with lipid profile in women older than 55 who were postmenopausal with a high probability.Methods. Our data were from Survey on Prevalence in East China for Metabolic Diseases and Risk Factors. 1795 women at the age of 55-89 were selected. Sex hormones and lipid profile were measured from morning serum. Linear and logistic regression analyses were used. Results. Lower FSH was associated with lower HDL-C, higher TG, TC/HDL-C ratio and LDL-C/HDL-C ratio (all P for trend<0.05), after adjusting for age and other sex hormones. Further adjustment for body mass index, diabetes and hypertension, the associations of FSH with lipid profile weakened, but the association of FSH quartiles with HDL-C and TC/HDL-C ratio was still significant (both P for trend<0.05). Compared with women in the highest FSH quartile, odds of low HDL-C (HDL-C <1.04mmol/L) in women in the lowest FSH quartile were 5.25 (95% confidence interval 1.60, 17.26) (P for trend <0.05) in fully adjusted model, and odds of TC≥6.22mmol/L, TG≥2.26mmol/L and LDL-C≥4.14mmol/L were not significant. LH did not show significant association with dyslipidemia.Conclusion. Lower FSH was associated with worse lipid profile in women older than 55. Diabetes, adiposity and hypertension mostly explained the association of FSH with TG and LDL-C/HDL-C ratio but only partially explained the associations of FSH with HDL-C and TC/HDL-C ratio.
Prognostic Significance of Carbohydrate Antigen 125 in Acute Heart Failure: A Prospective Comparative Study With N-terminal Pro-B-type Natriuretic Peptide
Authors: Zhang Ji , Li Wenhua , Cai Gaojun , Xiao Jianqiang , Hui Jie , Shi Ganwei , Yu Lei , Xue Sheliang 
Published: September 2021

Abstract
Background: In acute heart failure (AHF), elevated carbohydrate antigen 125 (CA125) and N-terminal pro-B-type natriuretic peptide (NTproBNP) have shown to correlate with adverse events. We sought to quantify their prognostic usefulness in predicting the 6-month combined endpoint of death/heart failure readmission.Methods: The study includes 352 patients admitted for AHF. The primary endpoint was 6-month combined endpoint of death/AHF rehospitalization. CA125 and NTproBNP were dichotomized according to the best cut-offs to predict 6-month primary endpoint. By multivariate Cox regression analysis, the independent association of CA125 and NTproBNP with the primary endpoint was assessed, and their incremental prognostic utility evaluated by net reclassification improvement (NRI) and integrated discrimination improvement (IDI) index. Results: A total of 47 (13.4%) deaths and 113 (32.1%) AHF rehospitalizations were identified at 6-month follow-up. The subjects with CA125≥39.7 U/ml and NTproBNP≥3900 pg/ml had significantly higher cumulative event rates (56.1% vs. 33.3% and 53.3% vs. 33.8%, both P<0.001). Elevated CA125 (HR 1.93; 95%CI [1.32-2.83]; P=0.001) was associated with higher HR than NTproBNP≥3900 pg/ml (HR 1.71; 95%CI [1.19-2.48]; P=0.004) after adjusting for established risk factors. Elevated CA125 still independently predicted adverse events when both CA125 and NTproBNP were entered together in the same multivariate model. Furthermore, risk reclassification analyses demonstrated significant improvements in NRI of 22.3% (P=0.014) and IDI of 2.7% (P=0.012) when adding CA125 to the base model + NTproBNP.Conclusions: Elevated CA125 and NTproBNP predicted adverse outcomes in AHF patients. CA125 added prognostic value to NTproBNP, and thus, their combination conferred greater predictive capacity.
Effects of Bacterial Organic Selenium, Selenium Yeast and Sodium Selenite on Antioxidant Enzymes Activity, Serum Biochemical Parameters, and Selenium Concentration in Lohman Brown-Classic Hens
Authors: Muhammad A. I. , Dalia A. M. , Loh T. C. , Akit H. , Samsudin A. A. 
Published: September 2021

Abstract
This study compares the effects of sodium selenite, selenium yeast, and enriched bacterial organic selenium protein on antioxidant enzyme activity, serum biochemical profiles, and egg yolk, serum, and tissue selenium concentration in laying hens. In a 112-d experiment, 144 Lohman Brown Classic hens, 23-wks old were divided into four equal groups, each has six replicates. They were assigned to 4 treatments: 1) a basal diet (Con), 2) Con plus 0.3 mg/kg feed sodium selenite (SS); 3) Con plus 0.3 mg/kg feed Se-yeast (SY): 4) Con plus 0.3 mg/kg feed bacterial enriched organic Se protein (ADS18) from Stenotrophomonas maltophilia bacteria. On d 116, hens were euthanized (slaughtered) to obtain blood (serum), liver organ, and breast tissue to measure antioxidant enzyme activity, biochemical profiles, and selenium concentration. The results show that antioxidant enzyme activity of hens was increased when fed bacterial organic Se (ADS18), resulting in a significant (P < 0.05) increase in serum GSH-Px, SOD, and CAT activity compared to other treatment groups. However, ADS18 and SY supplementation increase (P < 0.05) hepatic TAC, GSH-Px, and CAT activity, unlike the SS and Con group. Similarly, dietary Se treatment reduced total cholesterol and serum triglycerides concentrations significantly (P < 0.05) compared to the Con group. At 16 and 18 weeks, selenium concentration in hen egg yolks supplemented with dietary Se was higher (P < 0.05) than in Con, with similar patterns in breast tissue and serum. Supplementation with bacterial organic Se (ADS18) improved antioxidant enzyme activity, decreased total serum cholesterol and serum lipids, and increased Se deposition in egg yolk, tissue, and serum. Hence, organic Se may be considered a viable source of Se in laying hens.