bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encuesta para cuidadores de personas del espectro autista en Chile: primeras preocupaciones, edad del diagnóstico y características clínicas
Authors: García Ricardo , Irarrázaval Matías , López Isabel , Riesle Sofía , Cabezas Marcia , Moyano Andrea 
Published: April 2021

Los Trastornos del Espectro Autista (TEA) son desórdenes del neurodesarrollo de prevalencia en aumento. Las personas TEA tienen múltiples necesidades de salud, educación y comunitarias. En Chile existe escasa información al respecto.Objetivo: Conocer características demográficas, clínicas, primeras preocupaciones de sus cuidadores y la edad de diagnóstico de personas TEA.Pacientes y Método: Participaron padres/cuidadores de personas TEA, quienes respondieron la Encuesta de Necesidades de Cuidadores, desarrollada por Autism Speaks para este propósito específico y traducida al español. La encuesta comprende 4 secciones: información demográfica, características de la persona TEA, utilización pasada y presente de Servicios de Salud y Educación y percepciones de Padres/Cuidadores en cuanto a satisfacción, impacto, estigma, y calidad de vida. Aquí se reporta información proveniente de las dos primeras secciones.Resultados: Participaron 291 cuidadores (86% madres) de 291 personas TEA, 89% varones, de entre 1-40 años (X: 10,4 DE: 6,1). La edad promedio de primeras preocupaciones fue 29,2 m (DE: 23,8) y las principales fueron: dificultades en interacción (79,4%), respuesta inusual a estímulos sensoriales (69,8%), dificultades de comportamiento (65,3%), gestos/ movimientos inusuales (64,3%), falta de contacto visual (63,6%). La edad promedio de diagnóstico fue 58 m (DE: 36,5), con retraso promedio del diagnóstico de 29 m. El diagnóstico fue realizado por neurólogos pediátricos (44,7%), psiquiatras infantiles (19,2%), pediatras (5,5%). Las comorbilidades más frecuentes fueron compromiso de lenguaje, déficit cognitivo y problemas conductuales.Conclusiones: La tardía edad de diagnóstico y la gran brecha entre edad de primeras preocupaciones y diagnóstico de TEA representan una pérdida crítica de oportunidades de tratamiento, lo que puede poner en riesgo las posibilidades de un mejor pronóstico futuro.
Bentuk Keterdedahan Risiko Fatwa di Malaysia: Analisis Sorotan Literatur
Authors: Saad Mohd Nazril 
Published: April 2021

Abstract
Nowadays, there are many new issues arises in Malaysia which related to Islamic affairs especially in the matter of fatwa. Therefore, the role of fatwa which acts as an important reference institution for Muslims was expected to ensure the religious survival that was stipulated in the constitution will always be relevant and suitable throughout the era. The reinforcement and the development of fatwa must be parallel with the demand of era whereby the aspect of technology, trend and also current value will always be considered collectively. Currently, the main essential area of the fatwa is the establishment of the management area especially fatwa risk management as one of the important and relevant aspects. The question is, does the fatwa exposed to risk? What type of fatwa risk that has been discussed in the literature related to fatwa? What is the type of fatwa risk faced by Malaysia, specifically? This paper will answer the questions through the textual analysis of the literature review. Firstly, this paper will analyze the literature that discussed the fatwa risk. Secondly, this paper also will summarize the type of fatwa risks.
Abstrak
Mutakhir ini, pelbagai isu baru seringkali timbul melibatkan urusan hal ehwal Islam khususnya hal kefatwaan. Ini menjadikan peranan fatwa sebagai institusi rujukan penting umat Islam sangat diharapkan demi memastikan survival agama yang termaktub dalam perlembagaan sentiasa relevan dan sesuai sepanjang zaman. Pengukuhan dan pembangunan fatwa perlu seiring tuntutan zaman di mana aspek-aspek berupa teknologi, trend dan nilai-nilai semasa sentiasa diberi perhatian bersama. Salah satu keperluan semasa terutama bidang pemfatwaan ini adalah dengan menjadikan aspek pengurusan khususnya pengurusan risiko fatwa sebagai salah satu aspek yang penting dan sentiasa relevan. Persoalannya adakah fatwa itu terdedah kepada risiko? Apakah bentuk-bentuk risiko yang telah dibincangkan dalam karya-karya berkaitan fatwa? Bagaimana bentuk risiko fatwa yang dihadapi Malaysia khususnya? Kertas ini akan cuba menjawab kedua-dua persoalan ini menerusi analisis tekstual terhadap beberapa literatur. Pertama, menganalisis karya-karya yang membincangkan mengenai risiko fatwa. Kedua, merumuskan bentuk-bentuk yang terdapat dalam risiko fatwa.
Penerimaan Fatwa Dalam Kalangan Masyarakat Muslim Malaysia:Satu Tinjauan Literatur
Authors: Rosidi Mohd Harifadilah 
Published: April 2021

Peranan fatwa dalam masyarakat Malaysia tidak tersangkal pentingnya sehingga institusi fatwa bukan sehaja diwujudkan bagi setiap negeri malah Jawatankuasa Fatwa Majlis Kebangsaan juga ditubuhkan bagi peringkat persekutuan. Sehingga hari ini sudah banyak fatwa yang telah diputuskan di peringkat negeri mahupun kebangsaan namun sejauh manakah tahap penerimaan masyarakat terhadap fatwa tersebut. Justeru, kajian ini bertujuan untuk menyoroti kajian lepas berkaitan penerimaan fatwa dalam kalangan masyarakat Islam di Malaysia. Kaedah penyelidikan kualitatif melalui reka bentuk kajian analisis kandungan digunakan. Data yang dikumpul daripada bahan seperti buku, artikel dalam jurnal, prosiding, tesis dan disertasi dianalisis secara deskriptif. Hasil kajian menunjukkan tahap penerimaan fatwa dalam kalangan masyarkat Muslim di Malaysia masih rendah dengan tiga sebab utama iaitu ketidaksampaian fatwa ke pengetahuan masyarakat, kekeliruan terhadap fatwa dan perbincangan serta rujukan fatwa tidak terperinci. Di akhir kajian, penyelidik mengemukakan beberapa cadangan untuk memperbaiki tahap penerimaan fatwa dalam kalangan masyarakat Malaysia
Pengaruh Pembiayaan Ultra Mikro (UMi) terhadap Pertumbuhan Ekonomi Daerah Melalui Pertumbuhan Produksi Industri Mikro dan Kecil
Authors: Hia Vincencia Dian Priliyanti , Handaka Riya Dwi , Zega Yuris Trisman 
Published: April 2021

To maintain and increase economic growth rates above 5%, since 2017, Indonesia has launched an Ultra Micro Financing program for enterprises below micro and small categories (ultra micro enterprises). The financing is used to complement other types of financing, which is a bank loan for micro, small, and medium enterprises. Using regression method and causal testing to a panel data of 33 provinces in Indonesia during 2017 till 2018, this study aims to prove the direct and indirect effect of MSEs financing on regional economic growth and production growth in provincial regions in Indonesia. This research shows that the MSEs financing has positive impact on the manufacturing production growth but no significant impact on regional economic growth that is shown by Gross Domestic Product (GDP). This research also proves that manufacturing production has significant impact on GDP.
Dalam usaha mencapai tingkat ekonomi di atas 5%, sejak tahun 2017, pemerintah Indonesia telah menerbitkan Pembiayaan Ultra Mikro (UMi), suatu program pembiayaan yang menyasar usaha di bawah kategori mikro dan kecil, yaitu usaha ultra mikro. Pembiayaan ini merupakan program komplemen atas Kredit Usaha Rakyat (KUR), yang berbentuk pinjaman bank terhadap usaha mikro, kecil dan menengah (UMKM). Dengan metode regresi dan analisis jalur atas data panel dari 33 provinsi di Indonesia tahun 2017-2018, penelitian ini bertujuan untuk membuktikan ada tidaknya pengaruh Pembiayaan Ultra Micro terhadap pertumbuhan ekonomi regional dan pertumbuhan produksi industri mikro dan kecil di tingkat provinsi. Penelitian ini menunjukkan bahwa Pembiayaan Ultra Mikro memiliki pengaruh signifikan terhadap pertumbuhan produksi industri mikro dan kecil namun tidak memiliki dampak signifikan terhadap pertumbuhan ekonomi regional, yang ditunjukkan oleh PDRB.
Efektifitas Komunikasi Keselamatan dan Kesehatan Kerja (K3) dalam Mencegah Penularan Covid-19 di PLN UPDL Semarang
Authors: Adiwibowo Tri Sakti 
Published: April 2021

Abstract
The Covid-19 pandemic has affected the activities of the PLN UPDL Semarang as the provider of education and training at PLN to prevent the spread of the Covid-19 outbreak by arranging learning schedules and methods, implementing New Habit Adaptation (IMR) in the form of wearing masks, maintaining distance, washing hands with soap, and equip sufficient Personal Protective Equipment (PPE). This effort must be communicated to all workers as a form of compliance with the implementation of the Work Safety Management System (SMK3) in accordance with Government Regulation number 50 of 2012. The purpose of this study was to determine the effectiveness of communication in the UPDL Semarang environment in preventing Covid-19 transmission. In this study the authors used survey, observation, interview methods to obtain preliminary data. Furthermore, these data are evaluated and confirmed with secondary data related to the impact of communication. From this study, it was found that occupational safety and health communication in an effort to prevent the transmission of Covid-19 in the PLN UPDL Semarang environment reached an effectiveness of 78.29%. Things that need to be improved in this communication are the use of brochure / poster communication media
Redesain penampang kabel wiring APP pelanggan TM untuk perbaikan akurasi pengukuran kWh
Authors: Kurniadi Fadjar 
Published: April 2021

Abstract
Current Transfomer(CT) accuracy for big customers is very important. Constraints Execution of CT accuracy testing on big customers is quite a lot of customers and scattered, and longtime outage duration. Development of electronic kwh Meter for checking on-site CT customers as a solution to these problems. The onsite CT measurement method is carried out by comparing the primary and secondary of the CT by utilizing the current coil on the electronic kWh Meter. This method has several advantages, lower costs, easy procurement, easy and fast operation, so the duration of outages can be minimized. This method is very supportive in the implementation of the Revenue Assurance program.

Keywords: English, , 3-5 words

ABSTRAK
Akurasi CT (Current Transfomer) pada pelanggan besar sangat penting. Kendala Pelaksanaan pengujian akurasi CT pada pelanggan besar adalah pelanggan cukup banyak dan tersebar, dan waktu pemadaman yang lama. Pengembangan kwh Meter Alat untuk pengecekan CT Pelanggan secara on site sebagai solusi permasalahan tersebut. Metode penugukuran CT onsite dilaksanakan dengan membandingkan sisi primer dan sekunder CT dengan memanfaatkan kumparan arus pada kWh Meter elektronik. Metode ini memiliki beberapa keuntungan, antara lain biaya lebih murah, mudah pengadaan,mudah dan cepat dalam pengoperasiannya sehingga lama pemadaman dapat diminimalkan. Cara ini sangat mendukung dalam pelaksanaan program Revenue Assurance dalam memastikan kebenaran CT yang terpasang.

Kata kunci: Electronic Meter, CT Testing
Royalties para cultivares, legislação e regulação: Uma meta-análise
Authors: Silva Eduardo José de Souza , Silva-Mann Renata , Calazans Crislaine Costa 
Published: April 2021

O estabelecimento de padrões e princípios para aplicação de normas de proteção de direitos de propriedade intelectual sobre as cultivares é uma medida fundamental a qualquer país, essencialmente ao Brasil, um dos países mais ricos em biodiversidade do mundo. Dessa forma, é objetivo desse trabalho realizar uma revisão sistemática para analisar a produção científica em proteção das principais cultivares protegidas, identificar parâmetros e métodos existentes para definição das taxas de royalties e os mecanismos de cobrança adotados. Foi realizada uma revisão sistemática a partir de artigos publicados no período de 10 anos, de 2009 até 2019, nas bases científicas Scopus e Web of Science. Os termos e operadores booleanos: “(royalty) and (plant variety or cultivars)” foram prospectados em título ou resumo de artigos científicos. Foram prospectados 83 documentos indexados nas bases Scopus (37) e Web of Science (46). Após o tratamento dos dados e remoção de documentos duplicados restaram 43 artigos científicos. Com uma publicação média de 6,7 publicações por ano. Média de 10 citações por documento. Um total 171 autores e 271 co-autores foram elencados, sendo cinco documentos de autoria única e em média de 3,1 autores por artigo. Após o processo de refinamento, obteve-se uma amostra de estudo de 17 artigos. Os periódicos analisados não forneceram informações de como são taxados os royalties, apenas relataram o tipo de proteção e as cultivares estudadas.
PERBANDINGAN PRESTASI BELAJAR SISWA ANTARA METODE PEMBELAJARAN INQUIRY DENGAN METODE PEMBELAJARAN EKSPOSITORI PADA MATERI POKOK SEGITIGA SISWA SMP
Authors: Gunawan Gunawan , Murtalib Murtalib , Astuti Sri 
Published: April 2021

Tujuan penelitian ini adalah untuk mengetahui perbandingan prestasi belajar siswa melalui metode pembelajaran inquiry dengan metode pembelajaran ekspositori pada materi pokok segitiga kelas VII SMPN 7 Kota Bima Tahun Pelajaran 2013/2014. Jenis penelitian ini adalah eksperimen dengan pendekatan Quasi Eksperimen model Post test design Only dimana dua kelas eksperimen diberikan test prestasi belajar yang sebelumnya diberikan perlakuan pada pelaksanaan pembelajarannya yaitu kelas eksperimen I diterapkan dengan metode pembelajaran Inquiry sedangkan kelas eksperimen II diterapkan dengan Metode Pembelajaran Ekspositori. Populasi Penelitian ini adalah seluruh siswa kelas VII SMPN 7 Kota Bima. Dalam pengambilan sampel digunakan teknik purposive sampling sehingga diperoleh dua kelas yaitu kelas VIIA dan VIIB. Instrumen penelitian yang digunakan adalah Tes prestasi belajar yang sebelumnya telah divalidasi oleh peneliti. Sedangkan untuk menganalisis data dalam penelitian ini adalah dengan menggunakan Rumus t polled pada taraf signifikan 5%. Hasil penelitian diperoleh nilai rata-rata prestasi belajar kelas eksperimen I 78,76 dengan standar deviasi 9, 98 sedangkan pada kelas eksperimen II nilai rata-ratanya adalah 70,95 dengan standar deviasi sebesar 8,07 kemudian diperoleh pula nilai t hitung (2,79) > ttabel (1,73). Dari hasil tes tersebut disimpulkan bahwa prestasi belajar siswa kelas eksperimen I lebih baik dari pada prestasi belajar siswa kelas eksperimen II atau dengan kata lain bahwa prestasi belajar siswa yang diberikan perlakuan dengan metode pembelajaran inquiry lebih baik dibandingkan dengan prestasi belajar siswa yang diberikan dengan pendekatan ekspositori pada materi pokok segitiga kelas VII SMPN 7 Kota Bima Tahun Pelajaran 2013/2014.
Rapid Detection of Aspergillus fumigatus Using Multiple Cross Displacement Amplification Combined With Nanoparticles-Based Lateral Flow
Authors: Jiang Luxi , Li Xiaomeng , Gu Rumeng , Mu Deguang 
Published: April 2021

Aspergillus fumigatus is an opportunistic, ubiquitous, saprophytic mold which can cause infection in the lungs, nose, eyes, brain, and bones in humans, especially in immunocompromised patients. However, it is difficult to diagnose A. fumigatus infection quickly. Here, we introduce a new detection method, namely multiple cross displacement amplification (MCDA) combined with nanoparticle-based lateral flow biosensor (LFB) (MCDA-LFB), which was proved to be fast, reliable, and simple for detecting A. fumigatus. We designed a set of 10 primers targeting the gene annexin ANXC4 of A. fumigatus. The best MCDA condition is 66 °C for 35 min. The minimum concentration that can be detected by this method was 10 fg. In the case of 100 sputum samples, 20 (20%) and 15 (15%) samples were positive by MCDA-LFB and PCR method, respectively. MCDA-LFB and traditional culture method showed the same results. Compared with the culture method, the diagnostic accuracy of MCDA-LFB can reach 100%. It showed that the MCDA-LFB method has better detection ability than the PCR method. We found that the whole process could be controlled within 60 min including the preparation of DNA (20 min), MCDA reaction (35 min) and results reporting (2 min). These results show that this assay is suitable for the rapid, sensitive and specific detection of A. fumigatus in clinical samples.
Prevalence and Impact of Apolipoprotein E7 on LDL Cholesterol Among Patients With Familial Hypercholesterolemia
Authors: Tada Hayato , Yamagami Kan , Kojima Nobuko , Shibayama Junichi , Nishikawa Tetsuo , Okada Hirofumi , Nomura Akihiro , Usui Soichiro , Sakata Kenji , Takamura Masayuki , Kawashiri Masa-aki 
Published: April 2021

Background:It has been suggested that a rare mutant apolipoprotein E7, APOE7 (p.Glu262Lys, p.Glu263Lys), has been identified to be associated with hyperlipoproteinemia in the general population. Moreover, its prevalence has been shown to be 0.005–0.06%. However, there are no prior data regarding its prevalence and impact on serum lipids in patients with familial hypercholesterolemia (FH).Methods:We recruited 1,138 patients with clinically diagnosed FH [mean age = 48, men = 512, median low-density lipoprotein (LDL) cholesterol = 231 mg/dl]. The coding regions of three FH genes (LDLR, APOB, andPCSK9) and apolipoprotein E (APOE) gene were sequenced. We investigated the prevalence and impact of APOE7 mutant on serum lipid levels in patients with FH.Results:We identified 29 patients (2.5 %) with a mutant APOE7 (heterozygote), which is apparently much higher than that of the general population. Moreover, when we focus on those without FH mutation (n= 540), we identified 21 patients (3.9 %) with a mutant APOE7. Patients with a mutant APOE7 exhibited significantly higher median LDL cholesterol and triglyceride levels compared with those without this rare mutant (249 vs. 218 mg/dl,p&lt; 0.05, 216 vs. 164 mg/dl,p&lt; 0.05, respectively). Moreover, LDL cholesterol levels in the APOE7-oligogenic FH individuals, with a pathogenic mutation in FH genes and APOE7 mutant, were significantly higher than that in monogenic FH patients (265 vs. 245 mg/dl,p&lt; 0.05).Conclusion:We identified more patients with a mutant APOE7 than expected among those diagnosed with FH clinically, especially among those without FH-causing mutation. This implies a mutant APOE7 may be one of the causes FH, especially among those without FH mutations.
Experimental Study of Square CFST Stub Columns With a Low Steel Ratio Under Axial Loading
Authors: Lu Deren , Gong Yongzhi , Ding Faxing , Wang Liping , Deng Chao , Yuan Tao , Luo Chen , Ren Enhui 
Published: April 2021

This paper presents an experimental and numerical study on large dimension concrete-filled square low steel ratio steel tubular (CFST) stub columns under axial loading. Four specimens were designed to investigate the effects of steel ratio on the confinement effect of square CFST stub columns with a low steel ratio. ABAQUS was used to establish 3D finite element (FE) models for simulation of square CFST stub columns with a low steel ratio under axial loading. Furthermore, based on the experimental verification, the definition of the confinement index (ϕ = fsAs/(fcAc)) was discussed and the effect of the grade of concrete and steel tube was also investigated. With the same cross-sectional dimensions, the confinement effect of the square CFST stub columns with a low steel ratio (less than 0.05) was better than the others. The stub columns with the yield strength of steel tube fs = 235 MPa (345, 420 MPa) and compressive cubic strength of concrete fcu = 40 MPa (60, 80 MPa) can give fully demonstrate the material performance and reflect the better confinement effect. Based on the experimental results and FE modeling, a practical calculation formula for the ultimate load-carrying capacity of square CFST stub columns with a low steel ratio was proposed. The formula calculation results presented in this paper show good agreement with the experimental results. Compared with the existing formulas, the proposed formula has better precision.
Choriocapillaris Changes Are Correlated With Disease Duration and MoCA Score in Early-Onset Dementia
Authors: Zhang Shuting , Kwapong William Robert , Yang Tang , Liu Peng , Tuo Qingzhang , Cheng Yajun , Li Xue , Liu Ming , Lei Peng , Wu Bo 
Published: April 2021

Purpose: Imaging of the choroid may detect the microvascular changes associated with early-onset dementia (EOD) and may represent an indicator for detection of the disease. We aimed to analyze the in vivo choriocapillaris (CC) flow density in EOD patients using optical coherence tomography angiography (OCTA) and evaluate the association with its clinical measures.Methods: This cross-sectional study used the OCTA to image and analyze the choriocapillaris (CC) of 25 EOD patients and 20 healthy controls. Choriocapillaris flow density in the 3 mm area and 6 mm area was measured by an inbuilt algorithm in the OCT tool. Brain volume using magnetic resonance imaging and cognitive assessment was done and recorded.Results: Significantly reduced capillary flow density of the choriocapillaris was seen in EOD patients when compared to healthy controls in the 3.0 mm (P = 0.001) and 6.0 mm (P &lt; 0.001) area respectively. Montreal Cognitive Assessment (MoCA) scores in EOD patients positively correlated with choriocapillaris flow density in the 3 mm area (Rho = 0.466, P = 0.021). Disease duration of EOD patients also negatively correlated with choriocapillaris density in the 3 mm area (Rho = −0.497, P = 0.008).Discussion: Our report suggests that choriocapillaris damage may be a potential indicator of early-onset dementia. Microvascular impairment may be involved in the early phase of dementia without aging playing a role in its impairment.Clinical Trial Registration: www.ClinicalTrials.gov, ChiCTR2000041386.
Dynamic Change of Lymphocyte-to-Monocyte Is Associated With the Occurrence of POCD After Cardiovascular Surgery: A Prospective Observational Study
Authors: Zhao Qi , Gao Rui , Liu Changliang , Chen Hai , Zhang Xueying , Guan Jing , Xie Xiaoyu , Qiu Yanhua , Cheng Xu , Lv Peilin , Zhu Tao , Chen Chan 
Published: April 2021

Objective: Postoperative cognitive dysfunction (POCD) is a common and severe complication of cardiovascular surgery. Lymphocyte-to-monocyte ratio (LMR) has been reported to be an independent predictor of lots of diseases associated with inflammation, but the association between the LMR and POCD is not clear. The present study aimed to investigate the potential value of LMR level to predict POCD in patients undergoing cardiovascular surgery.Methods: A prospective observational study was performed on the patients diagnosed with heart diseases undergoing cardiovascular surgeries with cardiopulmonary bypass. The leukocyte counts were measured by blood routine examination preoperatively. Then we calculated the LMR by dividing the lymphocyte count by the monocyte count. Neurocognitive functions were assessed 1 day before and 7 days after surgery. Perioperative factors were recorded to explore the relationship between LMR and POCD.Results: In total, 75 patients finished the whole study, while 34 patients developed POCD. The preoperative LMR level in the POCD group was higher than that in the non-POCD group. A cutoff value of 4.855 was identified to predict POCD occurrence according to ROC curve. The perioperative dynamic change of LMR level in the POCD group was higher than those in the non-POCD group. A cutoff value of 2.255 was identified to predict POCD occurrence according to ROC curve and the dynamic LMR change had similar varying trend with preoperative LMR level.Conclusions: The dynamic change of LMR level in the peripheral blood is associated with occurrence of POCD, and preoperative LMR level seems to be a prognostic biomarker of postoperative cognitive dysfunction in patients after cardiovascular surgery.