bluuebunny/crossref_metadata_2025_split huggingface dataset:
microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression
Authors: Fitzsimons Stephen , Oggero Silvia , Bruen Robyn , McCarthy Cathal , Strowitzki Moritz J. , Mahon Niall G. , Ryan Nicola , Brennan Eoin P. , Barry Mary , Perretti Mauro , Belton Orina 
Published: January 2021

BackgroundAtherosclerosis is a chronic inflammatory disease driven by macrophage accumulation in medium and large sized arteries. Macrophage polarization and inflammation are governed by microRNAs (miR) that regulate the expression of inflammatory proteins and cholesterol trafficking. Previous transcriptomic analysis led us to hypothesize that miR-155-5p (miR-155) is regulated by conjugated linoleic acid (CLA), a pro-resolving mediator which induces regression of atherosclerosis in vivo. In parallel, as extracellular vesicles (EVs) and their miR content have potential as biomarkers, we investigated alterations in urinary-derived EVs (uEVs) during the progression of human coronary artery disease (CAD).MethodsmiR-155 expression was quantified in aortae from ApoE−/− mice fed a 1% cholesterol diet supplemented with CLA blend (80:20, cis-9,trans-11:trans-10,cis-12 respectively) which had been previously been shown to induce atherosclerosis regression. In parallel, human polarized THP-1 macrophages were used to investigate the effects of CLA blend on miR-155 expression. A miR-155 mimic was used to investigate its inflammatory effects on macrophages and on ex vivo human carotid endarterectomy (CEA) plaque specimens (n = 5). Surface marker expression and miR content were analyzed in urinary extracellular vesicles (uEVs) obtained from patients diagnosed with unstable (n = 12) and stable (n = 12) CAD.ResultsHere, we report that the 1% cholesterol diet increased miR-155 expression while CLA blend supplementation decreased miR-155 expression in the aorta during atherosclerosis regression in vivo. CLA blend also decreased miR-155 expression in vitro in human THP-1 polarized macrophages. Furthermore, in THP-1 macrophages, miR-155 mimic decreased the anti-inflammatory signaling proteins, BCL-6 and phosphorylated-STAT-3. In addition, miR-155 mimic downregulated BCL-6 in CEA plaque specimens. uEVs from patients with unstable CAD had increased expression of miR-155 in comparison to patients with stable CAD. While the overall concentration of uEVs was decreased in patients with unstable CAD, levels of CD45+ uEVs were increased. Additionally, patients with unstable CAD had increased CD11b+ uEVs and decreased CD16+ uEVs.ConclusionmiR-155 suppresses anti-inflammatory signaling in macrophages, is decreased during regression of atherosclerosis in vivo and is increased in uEVs from patients with unstable CAD suggesting miR-155 has potential as a prognostic indicator and a therapeutic target.
Pre-transplant Sarcopenic Obesity Worsens the Survival After Liver Transplantation: A Meta-Analysis and a Systematic Review
Authors: Hegyi Péter Jenö , Soós Alexandra , Hegyi Péter , Szakács Zsolt , Hanák Lilla , Váncsa Szilárd , Ocskay Klementina , Pétervári Erika , Balaskó Márta , Eröss Bálint , Pár Gabriella 
Published: January 2021

Background: The rising prevalence of cirrhotic cases related to non-alcoholic steatohepatitis has led to an increased number of cirrhotic patients with coexistence of obesity and muscle mass loss, known as sarcopenic obesity (SO). In patients undergoing liver transplantation (LT), the presence of SO may worsen prognosis, and increase morbidity and mortality.Objective: We aimed to evaluate the effect of the presence of pre-transplant SO on the outcomes of LT.Methods: A comprehensive search was performed in seven medical databases for studies comparing morbidity and mortality of patients with and without SO after LT. The primary outcome was overall mortality in the short- (1 year), intermediate- (3 years), and long- (5 years) term. We calculated pooled relative risks (RRs) with 95% confidence intervals (CIs). Heterogeneity was quantified with I2-statistics.Results: Based on the analysis of 1,515 patients from three articles, SO increased overall mortality compared to non-SO at short-, intermediate-, and long-term follow-up (RR = 2.06, 95% CI: 1.28-3.33; RR = 1.67, 95% CI: 1.10-2.51; and RR = 2.08, 95% CI: 1.10-3.93, respectively) without significant between-study heterogeneity for the short- and intermediate- term (I2 = 0.0% for both) and considerable heterogeneity for long-term follow-up (I2 = 81.1%).Conclusion: Pre-transplant SO proved to be a risk factor after LT and was associated with two times higher mortality at short- and long- term follow-up. Since SO worsens the prognosis of patients after LT, the inclusion of body composition assessment before LT may help to plan a more individualized nutritional treatment, physiotherapy, and postoperative care and may improve morbidity and mortality.
Associations of Fish and Omega-3 Fatty Acids Consumption With the Risk of Venous Thromboembolism. A Meta-Analysis of Prospective Cohort Studies
Authors: Zhang Yi , Ding Jun , Guo Hongbin , Liang Jieyu , Li Yusheng 
Published: January 2021

Objective: This study aims to investigate the effect of fish and omega-3 fatty acids consumption on the risk of VTE.Methods: A comprehensive literature search in the databases of PubMed, Web of Science, and Embase (up to September 2020), was conducted to identify the prospective cohort studies concerning the associations of fish and omega-3 fatty acids consumption with the risk of VTE. The pooled relative risk (RR) of VTE for the highest vs. lowest category of fish and omega-3 fatty acids consumption, as well as their corresponding 95% confidence interval (CI) were calculated.Results: A total of seven articles with eight prospective cohort studies were included. Specifically, six studies were related to fish consumption, and the overall multi-variable adjusted RR showed no significant relationship between fish consumption and the risk of VTE (RR = 1.02, 95% CI: 0.93–1.11; P = 0.709). In the four studies related to omega-3 fatty acids consumption, the overall multi-variable adjusted RR suggested that omega-3 fatty acids consumption was associated with a lower risk of VTE (RR = 0.89, 95% CI: 0.80–0.98; P = 0.024). Moreover, two studies were related to recurrent VTE, and the overall multi-variable adjusted RR demonstrated a significant inverse association between omega-3 fatty acids consumption and the risk of recurrent VTE (RR = 0.45, 95% CI: 0.25–0.81; P = 0.008).Conclusion: Although current evidence is still insufficient to demonstrate any relationship between fish consumption and the risk of VTE, omega-3 fatty acids consumption seems to be associated with a lower risk of both VTE and recurrent VTE. Further large well-designed prospective cohort studies are warranted to elaborate the issues examined in this study.
Development and Validation of a Radiomic-Based Model for Prediction of Intrahepatic Cholangiocarcinoma in Patients With Intrahepatic Lithiasis Complicated by Imagologically Diagnosed Mass
Authors: Xue Beihui , Wu Sunjie , Zheng Minghua , Jiang Huanchang , Chen Jun , Jiang Zhenghao , Tian Tian , Tu Yifan , Zhao Huanhu , Shen Xian , Ramen Kuvaneshan , Wu Xiuling , Zhang Qiyu , Zeng Qiqiang , Zheng Xiangwu 
Published: January 2021

BackgroundThis study was conducted with the intent to develop and validate a radiomic model capable of predicting intrahepatic cholangiocarcinoma (ICC) in patients with intrahepatic lithiasis (IHL) complicated by imagologically diagnosed mass (IM).MethodsA radiomic model was developed in a training cohort of 96 patients with IHL-IM from January 2005 to July 2019. Radiomic characteristics were obtained from arterial-phase computed tomography (CT) scans. The radiomic score (rad-score), based on radiomic features, was built by logistic regression after using the least absolute shrinkage and selection operator (LASSO) method. The rad-score and other independent predictors were incorporated into a novel comprehensive model. The performance of the Model was determined by its discrimination, calibration, and clinical usefulness. This model was externally validated in 35 consecutive patients.ResultsThe rad-score was able to discriminate ICC from IHL in both the training group (AUC 0.829, sensitivity 0.868, specificity 0.635, and accuracy 0.723) and the validation group (AUC 0.879, sensitivity 0.824, specificity 0.778, and accuracy 0.800). Furthermore, the comprehensive model that combined rad-score and clinical features was great in predicting IHL-ICC (AUC 0.902, sensitivity 0.771, specificity 0.923, and accuracy 0.862).ConclusionsThe radiomic-based model holds promise as a novel and accurate tool for predicting IHL-ICC, which can identify lesions in IHL timely for hepatectomy or avoid unnecessary surgical resection.
Validation and Psychometric Properties of the Arabic Version of the Duke Anticoagulation Satisfaction Scale (DASS)
Authors: AlAmmari Maha , Sultana Khizra , AlHarbi Sattam Nawaf , Marenga Ashwag Saud , AlTuraiki Abdulrahman , Althemery Abdullah Uthman , Alfaifi Abdullah Ali , AlShehri Asma , Aqeel Bander Fahad 
Published: January 2021

Background: To assess the health-related quality of life (HRQoL) of oral anticoagulant therapy users, different types of instruments are available, either general or specific tools like Duke Anticoagulation Satisfaction Scale (DASS). These tools allow the clinician to adjust the treatment regimen to focus on increasing anticoagulation adherence and reduce adverse clinical outcomes. This study aims to validate the translated Arabic version of DASS to assess the satisfaction level of patients using oral anticoagulants in the Arab population.Methods: The Duke Anticoagulation satisfaction scale (DASS) was translated into the Arabic language using MAPI group services. DASS was administered to 505 patients receiving anticoagulation with warfarin or apixaban. The generic scale measuring the quality of life EQ-5D-5L was also administered. Psychometric properties were assessed by Confirmatory Factor Analysis, internal consistency (Cronbach’s Alpha), exploratory factor analysis, convergent and divergent validity, and the correlation between the DASS and demographic variables, clinical characteristics, and the EQ-5D-5L instrument.Results: 439 subjects answered all the questions. From a total of 25 items, 22 grouped into three factors (limitations, positive impact, and negative impact). Each factor had good internal consistency (Cronbach Alpha 0.78–0.88). All the three factors correlated consistently with EQ-5D-5L measuring generic quality of life.Conclusion: The psychometric properties of the Arabic DASS version were comparable to the original English version. The Arabic version of the DASS showed very good reliability and validity. It can be used by health care professionals in other settings of anticoagulation clinics to assess patient’s satisfaction and limitations to anticoagulant treatment.
Key Clinical Interest Outcomes of Pharmaceutical Administration for Veterans With Post-Traumatic Stress Disorder Based on Pooled Evidences of 36 Randomised Controlled Trials With 2,331 Adults
Authors: Zhao Yi-Fan , Huang Zhen-Dong , Gu Hui-Yun , Guo Guang-Ling , Yuan Rui-Xia , Zhang Chao 
Published: January 2021

Background: The effects of drug treatment on veterans, who have a high risk of post-traumatic stress disorder (PTSD), are not clear, and the guidelines are different from the recommendations of the recent meta-analysis. Our goal was to find the efficacy and frequencies of complications of drugs that can treat PTSD in veterans.Method: We searched Ovid MEDLINE, Ovid Embase, The Cochrane Library and Web of Science until January 1, 2020. The outcomes were designed as the change of PTSD total scale, subsymptom score, response rate, frequencies of complications outcomes, and acceptability.Results: We included a total of 36 randomised controlled trials with a total of 2,331 adults. In terms of overall effect, drug treatment is more effective than placebo in change in total PTSD symptoms scale (SMD = −0.24, 95% CI [−0.42, −0.06]) and response (RR = 1.66, 95% CI [1.01, 2.72]). However, in terms of frequencies of complications, drugs generally had a higher withdrawal rate (RR = 1.02, 95% CI [0.86, 1.20]) and a higher frequencies of complications (RR = 1.72, 95% CI [1.20, 2.47]) than placebo. Risperidone showed a good curative effect in change in total PTSD symptoms scale (SMD = −0.22, 95% CI [−0.43, 0.00]) and acceptability (RR = 1.31, 95% CI [0.82, 2.59]). The drugs acting on 5−HT receptors, our results showed that symptoms of hyper−arousal (SMD = −0.54, 95% CI [−0.86, −0.21]), symptoms of re−experiencing (SMD = −0.62, 95% CI [−0.86, −0.39]) and symptoms of avoidance (SMD = −0.53, 95% CI [− 0.77,−0.3]), The drugs acting on dopamine receptors, our results showed that symptoms of re−experiencing (SMD = −0.35, 95% CI [−0.55, −0.16]) and the drugs acting on α2 receptor has a significant effect on reducing total PTSD symptoms scale (SMD = −0.34, 95% CI [−0.62, −0.06]).Conclusion: Drug therapy can effectively treat PTSD, but its frequencies of complications should be considered. Different from the guidelines for adult PTSD, this study supports atypical antipsychotics, selective serotonin reuptake inhibitors and receptors that act on 5-HT and dopamine for the treatment of PTSD in veterans. Based on evidence among these drugs, the risperidone is the most effective for veterans, otherwise, sertraline is used as an alternative.
PENGARUH MEREK, KEPERCAYAAN, DAN LOYALITAS KONSUMEN TERHADAP KEPUTUSAN PEMBELIAN PRODUK EMINA PADA MAHASISWA PRODI MANAJEMEN FAKULTAS EKONOMI UNIPA SURABAYA
Authors: Fatimah Putri Anggraini  , Christina Menuk Srihandayani  
Published: January 2021

Dilakukannya penelitian ini dengan tujuan mengetahui pengaruh merek, kepercayaan, dan IoyaIitas konsumen terhadap keputusan pembeIian produk Emina pada Mahasiswa Prodi Manajemen Fakultas Ekonomi dan Bisnis Universitas PGRI Adi Buana Surabaya. Penelitian ini mempergunakan pendekatan kuantitatif. Sampel diambil sebanyak 73 responden. Accidental Sampling sebagai teknik dalam mengambil sampel. Pengumpulan data melalui kuisioner kemudian dianalisis dengan uji regresi linier berganda dan uji signifikansi dengan program SPSS yang sebelumnya dilakukan dengan uji instrumen, uji asumsi klasik. Hasil pengujian menggunakan uji t, uji f dapat disimpulkan bahwa variabel merek, kepercayaan, dan IoyaIitas konsumen memiliki pengaruh secara parsial dan simultan untuk hasil yang signifikan terhadap keputusan pembeIian.
PENGARUH MOTIVASI, KARAKTERISTIK PEKERJAAN, SERTA IKLIM ORGANISASI MENGENAI KEPUASAN KERJA PADA KARYAWAN HOTEL IBIS BUDGET DIPONEGORO SURABAYA
Authors: Friskha Rostinaningsih  , Christina Menuk Srihandayani  , Bisma Arianto  
Published: January 2021

Eksplorasi ini bertujuan untuk memahami asertaya efek secara simultan serta parsial antara Motivasi, Karakteristik Pekerjaan serta Iklim Organisasi mengenai Kepuasan Kerja pada Karyawan Hotel Ibis Budget Diponegoro Surabaya. Besaran responden yang diambil sebanyak 30 orang karyawan, serta menggunakan teknik purposive sampling. Data dikumpulkan melewati kuesioner dengan menggunakan skala likert, kemudian melewati tahap uji validitas, reliabilitas, uji asumsi klasik serta terakhir teknik analisis yang digunakan yaitu Regresi Linier Berganda. Nilai Hasil dari pengolahan data, menunjukkan bahwa adanya pengaruh secara simultan Motivasi, Karakteristik Pekerjaan serta Iklim Organisasi mengenai Kepuasan Kerja Karyawan. Sesertagkan uji hipotesis secara parsial pada variabel Motivasi, menunjukkan Motivasi tidak berdampak signifikan pada Kepuasan Kerja. Selanjutnya, Karakteristik Pekerjaan serta Iklim Organisasi berdampak signifikan secara parsial mengenai Kepuasan Kerja pada Karyawan Hotel Ibis Diponegoro Surabaya.
PENGARUH CITRA MEREK DAN LIFESTYLE TERHADAP KEPUTUSAN MEMBELI SEPATU PETER KEIZA DI MATAHARI DEPARTMENT STORE CITO SURABAYA
Authors: Istiqomah Novitasari  , I Ketut Surabagiarta  , Evita Purnaningrum  
Published: January 2021

Penelitian ini bertujuan untuk mengetahui pengaruh citra merek dan lifestyle terhadap keputusan membeli sepatu peter keiza di matahari department store Cito Surabaya karena dari beberapa tahun kemarin mengalami penurunan yang sangat drastis untuk itu saya berinisiatif mencari salah satu penyebab turunnya minat pembeli di matahari cito surabaya dengan variabel citra merek dan lifestyle untuk sampel yang digunakan sebanyak 154 responden. Variabel yang digunakan penelitian ini terdiri dari variabel bebas (citra merek dan lifestyle) dan variabel terikat (keputusan membeli). Untuk penentuan jumlah sampel digunakan dengan teknik accidental sampling dan menggunakan metode analisis regresi linier berganda. Hasil dari analisis linier berganda dapat diketahui bahwa citra merek berpengaruh terhadap keputusan membeli.
Pengelompokan Provinsi Di Indonesia Berdasarkan Indikator Mutu Pendidikan Sekolah Menengah Pertama Tahun 2016 – 2018 Menggunakan Model Based Clustering
Authors: Uly Aldini  , Wara Pramesti  
Published: January 2021

Peran pendidikan dalam suatu bangsa bertujuan untuk membentuk sumber daya manusia yang terdidik, berkompeten dan berkarakter. Standar Nasional Pendidikan (SNP) ditetapkan sebagai acuan pengukuran mutu pendidikan di Indonesia, dengan melihat delapan aspek yaitu Standar Pendidikan dan Tenaga Kependidikan, Standar Sarana dan Prasarana, Standar Pengelolaan, Standar Pembiayaan Pendidikan, Standar Isi, Standar Proses, Standar Penilaian Pendidikan dan Standar Kompetensi Lulusan. Penelitian sebelumnya mengenai faktor dominan yang membentuk mutu pendidikan jenjang sekolah dasar dan menengah, menjelaskan bahwa terdapat lebih dari 50 indikator yang memuat data multivariat. Melalui indikator – indikator tersebut, penulis ingin mengukur mutu pendidikan dengan mengelompokan provinsi di Indonesia menggunakan metode Model Based Clustering. Metode ini sangat sesuai dengan data yang terindikasi kasus outlier, dengan pendekatan menggunakan jarak Mahalanobis dan jarak Robust akan diketahui di titik mana data tersebut mengalami outlier. Data yang terindikasi outlier menyebabkan tidak terpenuhinya asumsi normal multivariat, sehingga distribusi probabilitas yang sesuai adalah distribusi t multivariat. Penaksiran parameter menggunakan Maximum Likelihood Estimation terhadap Model Finite Mixture dengan t multivariat dipandang sebagai metode yang lebih robust terhadap data yang mengandung outlier. Model terbaik dari kelompok yang terbentuk akan dilihat melalui perhitungan ICL tertinggi
Pembelajaran Keterampilan Menjahit Dalam Mengembangkan Kemandirian Siswa Tunagrahita Ringan
Authors: Yuwono Imam , Mirnawati  , Kusumastuti Dewi Ekasari , Rahmah Nurbayti 
Published: January 2021

Penelitian ini bertujuan untuk mendeskripsikan tentang pelakasanaan pembelajaran keterampilan menjahit bagi siswa tunagrahita ringan di SMALB YPLB Banjarmasin yang meliputi 1) Perencanaan Pembelajaran, 2) Proses Pembelajaran, 3) Evaluasi Pembelajaran, 4) Faktor Penghambat dan Upaya. Penelitian ini menggunakan pendekatan kualitatif dan jenis penelitian deskriptif. Hasil peneitian menunjukkan bahwa pembelajaran keterampilan menjahit di SMALB YPLB Banjarmasin belum efektif dan sesuai dengan prosedur; 1) Tidak adanya perangkat perencanaan pembelajaran keterampilan menjahit seperti instrumen asesmen, silabus dan RPP. 2) Guru memberikan motivasi atau pun penguatan kepada siswa, guru menerapkan strategi serta metode pembelajaran yang disesuaikan dengan kebutuhan siswa dan menggunakan fasilitas penunjang keberhasilan proses pembelajaran dengan baik. 3) Guru tidak menggunakan alat penilaian dalam melakukan evaluasi pembelajaran keterampilan menjahit.4) faktor penghambat pelaksanaan pembelajaran keterampilan menjahit dalam mengembangkan kemandirian siswa tunagrahita ringan yaitu ruang keterampilan menjahit yang kurang mendukung, siswa jarang turun ke sekolah, guru tidak berlatar belakang keterampilan menjahit, siswa mudah bosan dan moodian. Adapun upaya yang dalam mengambangkan kemandirian siswa tunagrahita yaitu guru harus memahami karakteristik siswa, guru memotivasi siswa, guru mengkondisikan proses pembelajaran keterampilan, dan mendatangkan penjahit profesional.
Peran Kulit Nanas Sebagai Bioaktivator Dan Penambahan Biochar Tempurung Kelapa Dalam Meningkatkan Hasil Produksi Tanaman Kedelai (Glycine max (L) Merrill)
Authors: L. Andini , Ajiningrum P. S. 
Published: January 2021

Rendahnya produksi kedelai disebabkan oleh banyak faktor pembatas antara lain kesuburan tanah yang sangat rendah. Hal ini dipengaruhi oleh penggunaan pupuk kimia yang sedang menjadi trend di kalangan petani. Oleh karena itu untuk mengatasi permasalahan diatas adalah dengan memanfaatkan limbah kulit nanas sebagai bioaktivator dan penambahan biochar tempurung kelapa sebagai media. Penelitian ini bertujuan untuk mengetahui pengaruh berbagai macam kosentrasi bioaktivator limbah kulit nanas terhadap pertumbuhan, kadar klorofil total dan hasil produksi tanaman kedelai. Metode yang digunakan adalah metode ekperimental dilakukan di Green House Fakultas Sains Dan Teknologi Universitas PGRI Adi Buana Surabaya. Rancangan yang digunakan yaitu Rancangan Acak Lengkap (RAL) yang terdiri 6 perlakuan. Perlakuan 1 yaitu kontrol negatif (0%), perlakuan 2 kontrol positif (EM4), perlakuan 3 bioaktivator 10%, perlakuan 4 bioaktivator 20%, perlakuan 5 bioaktivator 30%, perlakuan 6 bioaktivator 40%. Masing-masing perlakuan di ulang 5 kali sehingga diperlukan 30 pot percobaan. Hasil penelitian menunjukan pengaruh nyata terhadap produksi pada konsentrasi 30%.
Kata Kunci : Kedelai (Gycine max (L.) Merrill), Bioaktivator Kulit Nanas, Biochar Tempurung Kelapa
Experiência de ações educativas em saúde com idosos na atenção primária
Authors: Torres de Medeiros Ana Claudia , Calixto Lucena Natally , Ribeiro Escorel Barros Dhébora Rhanny , De Sales Mélo Mayse Cristelle , Souto Policarpo Araújo Heloí­sa , da Fonseca Azevedo Araújo Kleane Maria 
Published: January 2021

Objetivo: Relatar experiências de ações educativas em saúde com idosos da Atenção Primária í Saúde. Método: Estudo qualitativo, descritivo, tipo relato de experiência, realizado em uma Unidade Básica de Saúde, no municí­pio de Campina Grande-PB. Para o desenvolvimento das ações educativas, utilizou-se como estratégia a implementação da Caderneta de Saúde do Idoso desenvolvendo as temáticas apresentadas nela. Resultados: Por meio de ações educativas proporcionadas pelo projeto de extensão, possibilitou-se implementar a Caderneta na unidade conforme preconização do Ministério da Saúde, otimizando o processo de trabalho e promovendo uma avaliação integral da pessoa idosa. Importante enfatizar a construção contí­nua do conhecimento por meio de ações coletivas proporcionando melhor troca de conhecimentos. Conclusão: Espera-se que esta vivência, sensibilize a comunidade acadêmica quanto í importância das práticas educativas por meio da extensão universitária, proporcionando a troca de conhecimentos de forma coletiva, contribuindo para a construção pessoal e profissional de todos que dele participaram.