bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecosystem services in connected catchment to coast ecosystems: monitoring to detect emerging trends
Authors: Brown Christopher J. , Saint Ange Chantal , Connolly Rod M. , Hasan Syezlin , Jackson Sue , McMahon Joseph M. , Smart James C. R. 
Published: July 2021

AbstractThere is an increasing need for long-term monitoring of ecosystems and their services to inform on-ground management and policy direction. The supply of many ecosystem services relies on connections that span multiple ecosystems. Monitoring the underlying condition of interconnected ecosystems, using established indicators, is therefore required to track effectiveness of past interventions and, ideally, identify impending change. Here we conduct performance testing of ecological indicators for a catchment-to-coast system with the aim of identifying the time-scales over which they respond to change. We chose a case-study of a coastal fishery in Northern Australia that exhibits strong catchment-to-coast connectivity, has long-term available data and is under threat from water resource development. We developed a novel approach to performance testing. Our model drew on state-space modelling to capture ecological dynamics, and structural equation modelling to capture covariation in indictors timeseries. We first quantified covariation among three established ecological indicators: pasture biomass, vegetation greenness and barramundi catch per unit effort. Covariation in the indicators was driven by river flow, with higher values of all indicators occurring in years with greater river flow. We then defined reference bounds for each indicator that accounted for natural variation in river flow. We predicted the emergence times for each indicator, as the time taken for each indicator to emerge from the background of natural variation. Emergence times quantified at 80% and higher confidence levels were >10 years in all cases. Past trends and current status of ecosystem service flows are often used by decision makers to directly inform near-term actions, particularly provisioning services (such as barramundi catch) due to their important contribution to regional economies. We found that the ecological indicators should be used to assess historical performance over decadal timespans, but not as short-term indicators of recent change. More generally, we offer an approach to performance testing of indicators. This approach could be useful for quantifying time-scales of ecosystem response in other systems where cross-ecosystem connections are important.
Spatio-temporal patterns of multi-trophic biodiversity and food-web characteristics uncovered across a river catchment using environmental DNA
Authors: Blackman Rosetta C. , Ho Hsi-Cheng , Walser Jean-Claude , Altermatt Florian 
Published: July 2021

AbstractAccurate characterisation of ecological communities with respect to their biodiversity and food-web structure is essential for conservation. However, combined empirical study of biodiversity and multi-trophic food-webs at a large spatial and temporal resolution has been prohibited by the lack of appropriate access to such data from natural systems. Here, we assessed biodiversity and food-web characteristics across a 700 km2riverine network over seasons using environmental DNA. We found contrasting biodiversity patterns between major taxonomic groups; local richness showed seasonally dependent and statistically significant increases and decreases towards downstream positions within the catchment for fish and bacteria respectively, while invertebrate richness remained unchanged with increased downstream position. The local food-webs, formed by these taxonomic groups, also showed a variation in their structure, such as link density and nestedness, to both space and time, yet these patterns did not necessarily mirror those of biodiversity and functional feeding characteristics. In order to conserve species diversity as well as their functional trophic integrity of communities, patterns of biodiversity and food-web characteristics must thus be jointly studied, as our results suggest that they are not directly scalable to each other even at the same spatial and temporal scales.
An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans
Authors: McEwan Andrew R. , Hing Benjamin , Erickson Johanna C. , Turnbull Yvonne , Delibegovic Mirela , Grassmann Felix , MacKenzie Alasdair 
Published: July 2021

AbstractObesity and anxiety are morbidities notable for their increased impact on society during the recent COVID-19 pandemic. Understanding the mechanisms governing susceptibility to these conditions will increase quality of life and our resilience to future pandemics. In the current study we explored the function of a highly conserved regulatory region (BE5.1) within the BDNF gene that harbours a polymorphism strongly associated with obesity (rs10767664; p=4.69×10−26). Analysis in primary cells suggested that the major T-allele of BE5.1 was an enhancer whereas the obesity associated A-allele was not. However, CRISPR/CAS9 deletion of BE5.1 from the mouse genome (BE5.1KO) produced no significant effect on the expression of BDNF transcripts in the hypothalamus, no change in weight gain after 28 days and only a marginally significant increase in food intake. Nevertheless, transcripts were significantly increased in the amygdala of female mice and elevated zero maze and marble burying tests demonstrated a significant increase in anxiety-like behaviour that could be reversed by diazepam. Consistent with these observations, human GWAS cohort analysis demonstrated a significant association between rs10767664 and anxiousness in human populations. Intriguingly, interrogation of the human GTEx eQTL database demonstrated no effect on BDNF mRNA levels associated with rs10767664 but a highly significant effect on BDNF-antisense (BDNF-AS) gene expression and splicing suggesting a possible mechanism. We discuss our findings within the context of the known function and regulation of BDNF in obesity and anxiety whilst exploring the validity of interrogating GWAS data using comparative genomics and functional analysis using CRISPR genome editing in mice.
Facilitation of TRKB activation by the angiotensin II receptor type-2 (AT2R) agonist C21
Authors: Laukkanen Liina , Diniz Cassiano R A F , Foulquier Sebastien , Prickaerts Jos , Castrén Eero , Casarotto Plinio C 
Published: July 2021

ABSTRACTBlockers of angiotensin II type-1 receptor (AT1R) exert antidepressant-like effects by indirectly facilitating the activation of the angiotensin II type-2 receptor (AT2R), which leads to increased surface expression and transactivation of tropomyosin-related kinase B receptors (TRKB). Compound 21 (C21) is a non-peptide AT2R agonist that produces neuroprotective effects. However, the behavioral effects of C21 and its involvement with the brain-derived neurotrophic factor (BDNF)-TRKB system still need further investigation.The aim of the present study was to assess the effect of C21 on the activation of TRKB and its consequences on conditioned fear. The administration of C21 (0.1-10μM/15min) increased the surface levels of TRKB but was not sufficient to increase the levels of phosphorylated TRKB (pTKB) in cultured cortical neurons from rat embryos. Consistent with increased TRKB surface expression, C21 (10μM/15min or 3 days) facilitated the effect of BDNF (0.1ng/ml/15min) on pTRKB in these cells. In contextual fear conditioning, the freezing time of C21-treated (administered intranasally) wild-type mice was decreased compared to the vehicle-treated group, but no effect of C21 was observed in BDNF.het animals. We observed no effect of C21 in the elevated plus-maze test for anxiety.Taken together, our results indicate that C21 facilitated BDNF effect by increasing the levels of TRKB on the cell surface and reduced the freezing time of mice in a BDNF-dependent manner, but not through a general anxiolytic-like effect.
New high-throughput endstation to accelerate the experimental optimization pipeline for synchrotron X-ray footprinting
Authors: Jain Rohit , Abel Donald , Rakitin Maksim , Sullivan Michael , Lodowski David T. , Chance Mark R. , Farquhar Erik R. 
Published: July 2021

Synchrotron X-ray footprinting (XF) is a growing structural biology technique that leverages radiation-induced chemical modifications via X-ray radiolysis of water to produce hydroxyl radicals that probe changes in macromolecular structure and dynamics in solution states of interest. The X-ray Footprinting of Biological Materials (XFP) beamline at the National Synchrotron Light Source II provides the structural biology community with access to instrumentation and expert support in the XF method, and is also a platform for development of new technological capabilities in this field. The design and implementation of a new high-throughput endstation device based around use of a 96-well PCR plate form factor and supporting diagnostic instrumentation for synchrotron XF is described. This development enables a pipeline for rapid comprehensive screening of the influence of sample chemistry on hydroxyl radical dose using a convenient fluorescent assay, illustrated here with a study of 26 organic compounds. The new high-throughput endstation device and sample evaluation pipeline now available at the XFP beamline provide the worldwide structural biology community with a robust resource for carrying out well optimized synchrotron XF studies of challenging biological systems with complex sample compositions.
The disclosure of the materiality process in sustainability reporting by Spanish state-owned enterprises
Authors: Ruiz-Lozano Mercedes , De Vicente-Lama Marta , Tirado-Valencia Pilar , Cordobés-Madueño Magdalena 
Published: July 2021

PurposeThis paper aims to assess the disclosure of the materiality process in the preparation of sustainability reports of state-owned enterprises (SOEs). This paper also explores the effects of regulation mandating that SOEs prepare sustainability reports. In the specific case of port authorities, the study analyses the influence of a sector guideline that determines what should be included and the structure of the report. Another aim of this paper is to delve into SOE's motivations for disclosing information on materiality assessments, using the assumptions of the different theories to explain their reporting practices.Design/methodology/approachUsing a sample of SOEs sustainability reports, a content analysis is undertaken. The methodology involves the analysis of the information disclosed by SOEs in Spain and the development of a materiality disclosure index. This index enables sampled entities to be classified on a scale of 0–5, based on the extent of their disclosures of the materiality determination process. This study also identifies several variables that explain differences in these disclosures.FindingsA low rate of information disclosed about the materiality process can be attributed to the desire of SOEs to create symbolic legitimacy. In a context where the disclosure of sustainability information is mandatory, only few organisations apply the principle of materiality to define the content of their sustainability reports. These results highlight that institutional isomorphism has only had a limited effect on the materiality process.Research limitations/implicationsLimitations associated with the sample size and composition of the sample by sector apply.Practical implicationsThis research shows that generally accepted reporting guidelines constitute a reference framework for sustainability reporting but that the principles underpinning these frameworks are not always implemented.Originality/valueThis study extends the literature on the implementation of the principle of materiality and uses disclosure theories to explain the actual reporting by SOEs of their materiality process.
Examining the financial relationships between producers and commission agents in the greenhouse vegetable farming industry in Turkey
Authors: Karaman Suleyman , Yigit Furkan 
Published: July 2021

PurposeThis paper is intended to investigate the economic, organizational and social factors affecting the receipt of advance payment by greenhouse vegetable producers from commission agents operating in the wholesale market.Design/methodology/approachThe data were gathered through questionnaire forms developed for this specific purpose through face-to-face interviews with 180 producers growing greenhouse vegetables in the central district and Serik, Antalya in the Western Mediterranean Region of Turkey. A logistic regression model was employed to analyse the factors affecting the likelihood of greenhouse vegetable growers getting advance from commission agents.FindingsA good financial status of enterprises producing greenhouse vegetables and the fact that their production input needs are met by cooperatives reduce their dependence on commission agents, thereby increasing their bargaining power when selling their products. Since producers can readily meet their need for the capital required for the vegetable production process from commission agents, they do not prefer to borrow from lending institutions making agricultural loans with requirements such as collateral. The fact that greenhouse vegetable farmers receive technical and market information and advice from commission agents strengthens their relationship with them.Originality/valueIt is the first study that evaluates in detail the financial aspect of the relationships between producers and commission agents in the greenhouse vegetables wholesale market. It contributes significantly to agricultural policymakers regarding the functioning of the greenhouse vegetable market, and in particular, the regulations on agricultural loans for production processes.
The promise and peril of youth entrepreneurship in the Middle East and North Africa
Authors: Krafft Caroline , Rizk Reham 
Published: July 2021

PurposeEntrepreneurship is promoted as a solution to high rates of youth unemployment around the world and especially in the Middle East and North Africa (MENA). This paper investigates the potential for youth entrepreneurship to alleviate unemployment, focusing on Egypt, Jordan and Tunisia.Design/methodology/approachThe authors examine who entrepreneurs are (in comparison to the unemployed), using multinomial logit models. The authors compare entrepreneurs' and wage workers' working conditions and earnings. They exploit panel data to assess earnings and occupational dynamics. They specifically use the Labor Market Panel Surveys of 2012 (Egypt), 2016 (Jordan), and 2014 (Tunisia), along with previous waves.FindingsThe authors find that entrepreneurs are the opposite of the unemployed in MENA. The unemployed are disproportionately young, educated and women. Entrepreneurs are older, less educated and primarily men. Entrepreneurship does not generally lead to higher earnings and does have fewer benefits.Originality/valuePromoting youth entrepreneurship is not only unlikely to be successful in reducing youth unemployment in MENA, but also, if successful, may even be harmful to youth.
Exploring the impact of socio-demographic characteristics on financial inclusion: empirical evidence from Tunisia
Authors: Amari Mouna , Anis Jarboui 
Published: July 2021

PurposeThis paper aim to fill the gaps by looking for the determinants and barriers related to financial inclusion. This study assesses the effect of socio-demographic variables on the use of formal financial inclusion services.Design/methodology/approachThis article examines the barriers to formal financial inclusion, focusing on saving and credit strands. The authors propose the probit model, allowing distinguishing the outcome variable into three categories: Formal inclusion, informal inclusion and financial exclusion. The authors apply this model to the Findex 2017 survey data.FindingsEstimation results propose that the trust to financial institutions, the distance to banks, the lack of documentation and the service costs are the main barriers, but these barriers affect the probability of using formal financial services differently according to the types of financial services (saving or credit).Research limitations/implicationsTo advance the formal financial inclusion in Tunisia, the authors call for continuing promoting financial literacy among adults and the young population, which helps them understand the benefits of using formal financial services. Financial literacy throws in constructing the individual trust toward the financial sector in a country that experienced several decades of political and economic instability.Originality/valueFinancial inclusion promotes growth through a broadening of the system and technology that can be a major catalyst for greater financial inclusion. It helps in the overall economic development of the underprivileged population and contributes to poverty reduction. It can also enhance the security of payments, and thus lower the incidence of associated crime.
The moderating effect of technology overload on the ability of online learning to meet students' basic psychological needs
Authors: James Tabitha L. , Zhang Jie , Li Han , Ziegelmayer Jennifer L. , Villacis-Calderon Eduardo D. 
Published: July 2021

PurposeMost students are considered digital natives and are presumably equipped to handle extensive technology use. However, online learning turns students into involuntary telecommuters when it is the primary modality. The prevailing trends of online learning, digital socialization, telehealth and other online services, combined with remote work has increased students' reliance on information and communications technologies (ICTs) for all purposes, which may be overwhelming. We examine how technology overload strains the ability of online learning to meet students' basic psychological needs (BPNs), which can decrease positive outcomes such as academic enjoyment and personal performance.Design/methodology/approachData was collected via an online survey of 542 university students and the proposed model was tested using partial least squares (PLS) regression.FindingsWe find that technology overload can diminish the positive relationship between online learning intensity and BPNs satisfaction, which is alarming because BPNs satisfaction is critical to students' positive experiences. Moreover, we find that technology overload and lack of technology experience can directly drive BPNs frustration, which decreases positive outcomes and increases academic anxiety.Originality/valueWe extend a theoretical framework for telecommuting to examine online learning. Additionally, we consider the role of technology overload and experience both as drivers and as moderators of students' BPNs satisfaction and frustration in online learning. Our results provide valuable insights that can inform efforts to rebalance the deployment of ICTs to facilitate online educational experiences.
Impact of income diversification strategy on credit risk and market risk among microfinance institutions
Authors: Duho King Carl Tornam , Duho Divine Mensah , Forson Joseph Ato 
Published: July 2021

PurposeThis study explores the effect of income diversification strategy on credit risk and market risk of microfinance institutions (MFIs) in Ghana as an emerging market.Design/methodology/approachThe study is based on quarterly data of averagely 271 MFIs that have operated from 2016 to 2018. The dataset is unbalanced and pooled cross-sectional with 3,259 data points. The study measures the diversification strategy using income diversification indices, and accounting ratios to measure the other variables. We utilised the weighted least squares (WLS) approach to explore the nexus.FindingsThe findings show that income diversification is associated with better loan quality and credit risk management. Market risk increases with the level of income diversification of microfinance firms. It is evident that large MFIs can manage their credit risks well and can have a low default rate, depicting an overall U-shaped nexus. On the other hand, the effect of size on market risk is an inverted U-shaped. The effect of asset tangibility on credit risk is positively significant while the effect on market risk is negatively significant. High profitability enhances credit risk management leading to lower loan losses while in the case of diversified and profitable MFIs, they tend to invest more in government securities. The results suggest that MFIs that hold more cash and cash equivalents tend to have high loan loss provision and more government securities suggesting much attention should be paid to optimal cash management.Practical implicationsThe results throw light on the credit risk and market risk profile of the firms and the effect of diversification strategies on them. The findings are relevant for effective macroprudential regulation, market regulation and prudential regulation of the microfinance sector.Social implicationsThe findings reveal the nature of income diversification strategy of MFIs in emerging markets such as Ghana, pointing out how they affect the risk exposure of MFIs that lend to the pro-poor population.Originality/valueThis is a premier formal assessment of the nexus between income diversification strategies and risk management among MFIs that serve the pro-poor population in the emerging market context.
We gain a lot…but what are we losing? A critical reflection on the implications of digital design technologies
Authors: Soulikias Aristofanis , Cucuzzella Carmela , Nizar Firdous , Hazbei Morteza , Goubran Sherif 
Published: July 2021

PurposeHighly sophisticated digital technologies have distanced architects and designers from intimate and immediate hand-drawing practices. Meanwhile the changes they rapidly bring come with undetected changes in cultural and social norms regarding the built environment. The growing dependence on computers calls for a more holistic, socially inclusive and place-responsive design practice. This paper aims to shed light on what we are losing in the design process as we rapidly transition to communicate architecture using digital media. The authors contemplate the paradigms in which the human body and physical objects still play an important role in today's design environment.Design/methodology/approachThe paper looks at current trends in developing and establishing “computer imaging” within architectural education, and the architectural profession through parametric design and the area of sustainability. In order to reveal novel and hybrid ways of architectural image-making, it also looks into art forms that already experiment with bodily practices in design by taking an artisanal animation project as a case study.FindingsThe renewed longing for craft, haptic environments, tactile experiences and hand-crafted artifacts and artworks that engage the senses can be exemplified with the success of the documentary Last Dance on the Main, an animated film on the endangered layers of human presence in one of Montreal's downtown neighborhoods. The open possibilities for creative hybridizations between the handmade and the digital in architecture practice and education are exposed.Originality/valueThe influence of film on the perception and consequent design of cities is well documented. There is little literature, however, on how the materiality and process of artisanal film animation can provide alternative, if not additional, insights on how to communicate various aspects of the built environment, particularly those rooted in the human body. Furthermore, handmade film explores a broader understanding of sustainability, which includes considerations for social and cultural contexts.