bluuebunny/crossref_metadata_2025_split huggingface dataset:
The 532 Nm Laser Treatment Promotes the Proliferation of Tendon- Derived Stem Cells and Up-Regulates Nr4a1 to Stimulate Tenogenic Differentiation
Authors: Li Ming , Zhu Yi-Ming , Pei Qing , Deng Yu-Hao , Ni Tao 
Published: November 2021

Abstract
Background: The combination of low-level laser therapy (LLLT) and stem cell transplantation with tendon-derived stem cells (TDSCs) as seed cells provides a new treatment strategy for tendon injury. Nevertheless, the effect of LLLT on the biological behavior of TDSCs and its internal mechanisms remain unclear. This study aimed to verify the effect of LLLT with a wavelength of 532 nm on the proliferation and differentiation of TDSCs of Sprague-Dawley (SD) rats. Methods: TDSCs were isolated from Achilles tendons of SD rats and identified by cell morphology and flow cytometric analysis. Energy density gradient experiment was performed to determine the ideal energy. Then TDSCs were treated with LLLT using a wavelength of 532 nm at a fluence of 15 J/cm2. Cell response after irradiation was observed at 6, 12 and 24 hours to ascertain cell morphology and cell proliferation. The RNA expression levels of the key genes of TDSCs differentiation, including Scx, Tnmd, Mkx and Dcn, PPARγ, Sox9 and Runx2, were detected by RT-PCR. Then gene chip microarray was used to detect the expression of differential genes after 532 nm laser intervention in TDSCs, and the target genes were screened out to verify the role of target genes in this process.Results: When the 532 nm laser energy density was 15 J/cm2, the proliferation capacity of TDSCs was improved (2.73 ± 0.24 vs. 1.81 ± 0.71, P < 0.05), and the expression of genes related to tenogenic differentiation of TDSCs was significantly increased (P < 0.01), showing the potential of tenogenic differentiation. After RNA-seq and bioinformatics analyses, we speculated that Nr4a1 was involved in the tenogenic differentiation process of TDSCs regulated by 532 nm laser treatment. Subsequent experiments confirmed that Nr4a1 regulated the expression of the tenogenic differentiation genes scleraxis (Scx) and tenomodulin (Tnmd) in TDSCs, affecting the process. Conclusion: A 532 nm laser with 15 J/cm2 regulated the process of TDSC proliferation and tenogenic differentiation by up-regulating Nr4a1, which could accelerate tendon healing.
A Model for an Educational Virtual Ward Round
Authors: Bowers Sarah Pauline , Dickson Philip J , Thompson Katharine 
Published: November 2021

Abstract
Background COVID-19 led to global disruption of both healthcare delivery and undergraduate medical education with suspension of clinical placements in alignment with government and university guidelines. To facilitate ongoing palliative care education, we aimed to develop a model for delivering virtual palliative care teaching and to assess the suitability of this as an alternative to in-person teaching. Method Basic technology (iPad and linked computer) were used to facilitate video conferencing, via the secure platform Microsoft Teams, between a consultant-led ward round in a specialist palliative care unit and fourth year medical students located in the education department of the unit. This was evaluated using electronic survey responses from patients, medical students and medical staff with generation of quantitative and qualitative data.Results Medical students greatly appreciated the opportunity to maintain attendance at clinical sessions during COVID-19. Quantitative and qualitative feedback demonstrated that the virtual ward round model effectively met medical students’ educational needs, particularly in relation to holistic assessment, pain management and communication skills. Only minor technological difficulties were noted. Feedback indicated that the use of technology to allow medical education was acceptable to patients, who were open and willing to adapt. Patients acknowledged that without medical students’ physical presence on ward rounds, there was an element of discretion; clinicians also found this to be beneficial. Conclusion COVID-19 has forced changes in the delivery of medical education. Virtual ward rounds are an effective method for delivering high quality palliative care teaching and are acceptable to patients, medical students and clinicians alike. Additional benefits beyond COVID-19 included allowing students to be present discretely during sensitive conversations whilst still meeting their learning outcomes.
Robust Optimal Placement and Sensitivity Analysis of Multiple Transmitting Antennas Under Uncertainty: A New Surrogate-Based Evolutionary Algorithm
Authors: Parnianifard Amir , Mumtaz Shahid , Chaudhary Sushank , Imran Muhammad Ali , Wuttisittikulkij Lunchakorn 
Published: November 2021

Abstract
Transmitting antenna positioning or transmitter placement is a well-known NP-hard optimization problem pertinent to communication systems. Furthermore, it is of practical importance to yield an optimal location of transmitters to ensure low sensitivity with respect to potential uncertainties. Notwithstanding, incorporating uncertainties in the optimization problem can highly increase the computational expenses. This paper aims at the development of a new reducedcost algorithm for a multi-objective robust transmitter placement under uncertainties. Toward this end, a new hybrid surrogate-metaheuristic approach is developed using Grey Wolf Optimizer (GWO) and the Kriging surrogate in a mathematical framework of a robust dual-surface model. The proposed algorithm is also able to analyze the sensitivity of the obtained optimal results. The latter is achieved by obtaining the bootstrapped confidence regions without extra simulation experiments. The paper investigates the performance of the proposed algorithm for robust optimal placing of two, three, and four transmitters, under uncertainties concerning the transmitting antenna gain. The results demonstrate the utility and the efficiency of the proposed method in rendering the robust optimal design and analyzing the sensitivity of the transmitter placement problem under practically acceptable computational efforts.
Fast Chaotic Encryption Scheme Based on Separable Moments and Parallel Computing
Authors: Kamrani Abdelhalim , Zenkouar Khalid , Najah Said , Fadili Hakim El 
Published: November 2021

Abstract
In this paper, we propose three novel image encryption algorithms. Separable moments and parallel computing are combined in order to enhance the security aspect and time performance. The three proposed algorithms are based on TKM (Tchebichef-Krawtchouk moments), THM (Tchebichef- Hahn moments) and KHM (Krawtchouk-Hahn moments) respectively. A novel chaotic scheme is introduced, which allows for the encryption steps to run si multaneously. The proposed algorithms are tested under several criteria and the experimental results show a remarkable resilience against all well-known attacks. Furthermore, the novel parallel encryption scheme exhibits a drastic improvement in the time performance. The proposed algorithms are compared to the state-of-the-art methods and they stand out as a promising choice for reliable use in real world applications.
COVID-19: DESAFIOS PARA ASSISTÊNCIA MATERNOINFANTIL E AMAMENTAÇÃO EXCLUSIVA NO PERÍODO NEONATAL
Authors: Ferreira Pinheiro Josilene Maria , Tinôco Lorena dos Santos , Soares Fernandes Xavier Ana Márcia , Germano de Araújo Mayara Gabrielly , Macedo Barbosa Wanessa Pinheiro , Andrade Fábia Barbosa 
Published: November 2021

Introdução: O novo coronavírus, denominado SARS-CoV-2, multiplica-se ainda de forma acelerada em alguns países, causando impactos na qualidade de vida da população. A transmissibilidade vertical ou pelo leite materno ainda é uma questão controversa que, dada as incertezas, pode comprometer a interação equipe/família/mãe/recém-nascido e a oferta do aleitamento materno nas primeiras horas de vida, com sua permanência no período neonatal. Objetivo: Discutir os desafios da saúde maternoinfantil e do aleitamento materno no contexto da pandemia causada pela COVID-19. Metodologia: Estudo do tipo descritivo, no qual foram verificados boletins, portarias e manuscritos relacionados ao aleitamento materno e aos cuidados maternos e neonatais para prevenção e transmissão do SARS-CoV-2. Resultados: Os desafios perpassam pelo pré-natal, parto e puerpério devido às dificuldades assistenciais, medidas de proteção para o binômio, vulnerabilidade social e não cumprimento das recomendações. Conclusões: As dificuldades encontradas na pandemia podem refletir na saúde materna, na promoção do aleitamento materno, e na qualidade da alimentação e nutrição do recém-nascido.
Palavras-Chave: Infecções por Coronavírus; Leite Humano; Aleitamento Materno; Saúde Materno-Infantil.
Ergonomia e qualidade de vida no trabalho: um estudo de caso no agronegócio brasileiro
Authors: Hikari Kumagai Bianca , Polezi Munhoz Igor , Akkari Alessandra Cristina Santos 
Published: October 2021

O agronegócio possui grande representação no setor econômico brasileiro com significativa participação no PIB. Contudo, trata-se de um dos segmentos com o maior número de acidentes ocupacionais e alta prevalência de riscos ergonômicos. Logo, esse artigo objetivou diagnosticar, sob enfoque da ergonomia e da qualidade de vida no trabalho (QVT), a realidade de trabalhadores rurais, utilizando como modelo de estudo uma empresa familiar agrícola no estado de São Paulo. A partir de uma pesquisa exploratória e descritiva, aplicou-se o método observacional assistemático e coletou-se dados por meio do Questionário Nórdico de Sintomas Osteomusculares (QNSO) e do Questionário World Health Organization Quality of Life (WHOQOL-bref), seguindo-se de tratamento estatístico descritivo e inferencial. Os principais pontos de dores identificados referiram-se ao quadril/membros inferiores (40%) e região dorsal (40%), associando-se esses relatos às atividades repetitivas, alta incidência de trabalho estático, movimentação manual de carga e má postura observadas in loco. Estatisticamente, verificou-se que as dores na região dorsal estão relacionadas ao tempo de trabalho na função (p = 0,009), bem como há relação com os desconfortos da região cervical (p = 0,001). Ainda, os trabalhadores apresentaram elevada QTV (3,9 ± 0,7), apontando como única fragilidade a influência do sono no trabalho (2,7 ± 1,1). Constatou-se que manifestações de dores e desconfortos deve-se à falta de alinhamento das atividades laborais com os preceitos ergonômicos, porém sem impacto direto na QVT na amostra estudada. Esse artigo contribui para discussões gerenciais sobre planos e práticas que prezem pela saúde e bem-estar do trabalhador agrícola para otimizar indicadores sociais e econômicos no agronegócio brasileiro.
Economia circular: estudo de caso na empresa ABC
Authors: Venanzi Délvio , Da Silva Orlando Roque , Seifert Amanda 
Published: October 2021

A economia circular (EC) é vista como um processo chave para promover a dissociação entre o elevado consumo de recursos e o crescimento econômico. Ela apresenta inúmeros benefícios, mas ainda há lacunas entre sua teoria e o processo de implementação. O presente artigo visa analisar e salientar as vantagens e benefícios da aplicação da economia circular, bem como identificar pontos importantes para enfrentar as barreiras e alcançar as oportunidades no setor de manufatura. A estratégia de pesquisa adotada foi a pesquisa exploratória realizada por meio de entrevistas, com pessoas da empresa, envolvidas no assunto em questão. O resultado encontrado mostrou que o desenvolvimento de parcerias é fundamental na economia circular. Na empresa pesquisada as parcerias, para otimizar a logística reversa, permitiram reduzir os custos do cliente em até 30% e elevar o tempo de coleta em 50%.
The Antimitotic Podophyllotoxin and its Derivatives Recent Synthetic
Advances
Authors: Saleem Rahman Shah Zaib , Riaz Sharon , Khan Khalid Mohammed , Chotana Ghayoor Abbas , Faisal Amir 
Published: November 2021

:
The substantial antimitotic potential of podophyllotoxin and its derivatives has attracted
both synthetic and medicinal chemists to expand the chemical space for the subsequent biological
evaluation of these compounds. The interest ranges from total synthesis, hemi-synthesis, one-pot
synthetic approaches and structure-activity relationship studies. In the first segment of the review,
we present recent development in the synthesis of podophyllotoxin and also describe its mode of action.
the second section covers the synthesis and the structure-activity relationships of podophyllotoxin
derivatives, along with the discussion of important structural features required by the
molecule for displaying antimitotic activity. The last part describes the synthesis and biological
evaluation of potent 4-aza podophyllotoxin derivatives. this review is of interest to chemists who
study natural and synthetic compounds for drug discovery.
Eksistensi sedekah bumi di era modern: Desa wisata Plesungan Kecamatan Gondangrejo Kabupaten Karanganyar
Authors: Masruroh Nabila , Rahman Abdul , Hermawan Yosafat 
Published: November 2021

Masyarakat Jawa tidak lepas dengan budaya juga tradisi yang menjadi ciri khas daerahnya. Salah satunya tradisi sedekah bumi di Jawa menjadi manifestasi bentuk rasa syukur. Warga Plesungan masih menjaga tradisi ini meskipun mayoritas bukan petani dan tergolong masyarakat urban. Tujuan penelitian ini melihat sejarah tradisi sedekah bumi di era modern, makna yang terkandung pada tradisi sedekah bumi, proses tradisi dan dinamika untuk menyimpulkan eksistentesinya. Metode penelitian yang digunakan adalah deskriptif kualitatif untuk menggambarkan fakta tentang tradisi sedekah bumi. Sumber data penelitian adalah informan dan fenomena tradisi sedekah bumi. Teknik pengumpulan data dengan observasi, wawancara, dan dokumentasi. Teknik analisis data dengan menggunakan tiga tahap yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Penelitian ini menyimpulkan bahwa tradisi sedekah bumi telah dilaksanakan turun-temurun sejak nenek moyang, masyarakat melihat tradisi ini wajib dilaksanakan dan dilestarikan karena banyak menanamkan nilai-nilai luhur yang baik seperti gotong royong juga silaturahmi dengan adanya perubahan tersebut masyarakat Desa Plesungan mengambil sisi baik sebagai pengenalan tradisi sedekah bumi kepada generasi penerus agar tidak hilang ditelan zaman.

Javanese society cannot be separated from the culture and traditions that characterize the region. One of them is the earth alms tradition in Java which is a manifestation of gratitude. The people of Plesungan still maintain this tradition even though the majority are not farmers and belong to the urban community. The purpose of this study is to look at the history of the earth alms tradition in the modern era, the meaning contained in the earth alms tradition, the traditional process and the dynamics to conclude its existence. The research method used is descriptive qualitative to describe facts about the earth alms tradition. Sources of research data are informants and the phenomenon of the earth alms tradition. Data collection techniques by observation, interviews, and documentation. The data analysis technique uses three stages, namely data reduction, data presentation, and drawing conclusions. This study concludes that the earth alms tradition has been carried out from generation to generation since the ancestors, the community sees this tradition as obligatory to be implemented and preserved because it instills many good noble values ​​such as mutual cooperation and friendship. the tradition of giving the earth alms to the next generation so that it is not lost in time.
(RE)VER O MUNDO PARA LER O ESPAÇO: EXISTÊNCIA E (AUTO)CONHECIMENTO NA GEOGRAFIA HUMANISTA
Authors: Souza Júnior Carlos Roberto Bernardes de , Almeida Maria Geralda de 
Published: November 2021

A considerar as proposições da fenomenologia existencialista, principalmente respaldada em Merleau-Ponty, o texto analisa as possibilidades explicativas acerca das lógicas vigentes na prática de pesquisa dos geógrafos humanistas. Por meio do conceito de mundo e de sua inseparabilidade do sujeito que nele se insere, visa-se decifrar as espacialidades do cotidiano e compreender as maneiras pelas quais os seres humanos vivem em sua geograficidade. A metodologia empregada foi revisão bibliográfica e correlação com as teorias da fenomenologia. Entende-se que é fundamental a adoção de uma postura de aventura e curiosidade em relação ao cosmo em que o geógrafo se insere para que seja possível ler efetivamente o espaço.Palavras-chave: fenomenologia; ser-no-mundo; geograficidade.
(RE)VIEW THE WORLD TO READ THE SPACE: EXISTENCE AND (SELF)KNOWLEDGE AT HUMANISTIC GEOGRAPHY
Abstract: Considering the propositions of existentialist phenomenology, mainly based on Merleau-Ponty, the text analyzes the explicative possibilities of the major logics at the humanistic geography practices are analyzed. By the means of the concept of world and its inseparability from the subject that inserts itself into it, it attempts to unravel the spacialities of daily life and comprehend the ways in which human beings live their geographycity. The used methodology was bibliographical revision and correlation to phenomenological theories. It its understood that the assumption of an adventurous and curious posture in relation to the cosmos where the geographer is fundamental in order to read effectively the space.Keywords: phenomenology; being-in-the-world; geographicality.
(RE)VUE LE MONDE POUR LIRE L’ESPACE : EXISTENCE ET (AUTO)CONNAISSANCE A LA GEOGRAPHIE HUMANISTE
Résumé: Au considérer les propositions de la phénoménologie existentialiste, particulièrement cette appuyée en Merleau-Ponty, cet essai analyse les possibilités explicatives sur les logiques en vigueur dans les pratiques de recherche des géographes humanistes. Á travers du concept de monde et de son inséparabilité avec le sujet qui est dessus, on vise déchiffrer les spatialités du quotidien et comprendre les façons par lesquelles les êtres humains vivent en son géographicité. Les méthodologies utilisées ont été le révision bibliographique et corrélation avec les théories de la phénoménologie. On entend que l’adoption d’une posture de curiosité et aventure en relation au cosmo où le géographe est inséré est fondamental pour la possibilité de lire effectivement l’espace.Mots-clé: phénoménologie; être-au-monde; géographicité.
Code-Switching in Online Synchronous Learning
Authors: Rinawati Ni Kadek Ayu , Putra I Nyoman Adi Jaya 
Published: October 2021

The Covid-19 outbreak has "forced" face-to-face teaching and learning to be entirely online. This situation also affects prospective EFL teachers in conducting teaching practicums. This study aims to analyze prospective EFL teachers using code-switching in online discussions through WhatsApp group chats. Code-switching is a popular language feature commonly used in communication. Furthermore, this research aims to identify the types of code-switching according to Poplack's theory and to find out the code-switching function based on Sert's theory. This type of research is qualitative. The subjects of this study were six prospective EFL teachers and their students. Primary data was collected from online discussions of student teachers through their WhatsApp chat groups, and then the discussions were transcribed into transcripts. The technique used to analyze the data is descriptive qualitative and quantitative analysis. The first study's results in terms of types of code-switching revealed that all participants practiced code-switching in online teaching and learning through WhatsApp group chats. The discussion provides three types of code-switching based on Poplack's theory: tag-switching, inter-sentential switching, and intra-sentential switching. Furthermore, tag switching is often used in online discussions.
Antelias kirja Kaija ja Heikki Sirenin arkkitehtuurista
Authors: Nikula Riitta 
Published: October 2021

Kirja-arvio teoksesta Juhana Lahti & Frans Autio, toim. Kaikki ja ei mitään. Arkkitehdit Kaija + Heikki Siren (Helsinki: Suomen arkkitehtuurimuseo, 2020).
Teachers Strategy in Solving Students Ability to Read and Write Qur’an at Government Schools
Authors: Fitri Fitri , Kamaruddin Kamaruddin 
Published: October 2021

This study discusses teachers strategy of Islamic Education in overcoming students difficulties of reading Al-Qur'an a State Junior High School. The problems that will be addressed included what strategies were used by the teachers in overcoming students difficulties in reading Al-Qur'an and who the strategies were implemented to solve the problems. In conducting the study, we used a qualitative case study method. The case of this study was a state junior high school in West Sulawesi province. Data were gathered through direct field observation, in-depth interviews which involve teachers and the school principle. We also analyzed written material, such as the school teaching activities, to understand how the teachres solve students difficulties in reading al-Quran. Our study found that the strategies to overcome students difficulties in reading al-Quran included the determination of the qualification of learners. Hold a special coaching for students who experience difficulties in reading Quran. Then the teachers made cooperation with fellow teachers and learners. Finally, the teachers familiarized the students to read Al-Qur'an.
Effects of a flotation vest and water flow rate on limb kinematics of Siberian Huskies swimming against a current
Authors: Fisher Corey J. , Scott Karen C. , Reiter Hayley K. , Reid Melissa A. , Roe Charles M. , Colee James C. , Hill Richard C. 
Published: November 2021

Abstract

OBJECTIVE
To evaluate the effects of a flotation vest (FV) and water flow rate (WFR) on limb kinematics of dogs swimming against a current.

ANIMALS
7 (1 male and 6 female) healthy adult Siberian Huskies.

PROCEDURES
Dogs were habituated to swim with and without an FV beside an investigator in a continuous-flow pool against WFRs up to 2.9 km/h. During each of 4 experimental sessions in a repeated-measures study, markers were wrapped around the right carpus and tarsus, and a video was recorded while each dog swam with or without an FV for about 2 minutes at each of 7 WFRs between 0 and 2.9 km/h when the WFR was incrementally decreased or increased. Motion tracking software was used to measure stroke excursion and frequency.

RESULTS
Stroke excursion varied more than frequency among all dogs and in response to changes in experimental conditions. The male dog and 1 female dog were unable to complete the study. For the remaining 5 dogs across all experimental conditions, mean tarsus excursion was 30% that of the carpus. Mean total excursion (sum of the excursion-frequency products for the carpus and tarsus) decreased when an FV was worn and increased with WFR by 69% and 19% when WFR was incrementally increased and decreased, respectively.

CONCLUSIONS AND CLINICAL RELEVANCE
In dogs, range of motion during swimming was greater for the carpus than tarsus, when an FV was not worn, and increased more with WFR when WFR was incrementally increased. Those factors should be considered during swimming-based rehabilitation.