bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer
Authors: Meyer Hans-Jonas , Höhn Anne Kathrin , Surov Alexey 
Published: November 2021

Abstract
Objectives
The present study used dynamic-contrast enhanced MRI (DCE-MRI) to elucidate possible associations with tumor-infiltrating lymphocytes (TIL), stroma ratio and vimentin expression in head and neck squamous cell cancer (HNSCC).

Methods
Overall, 26 patients with primary HNSCC of different localizations were involved in the study. DCE-MRI was obtained on a 3 T MRI and analyzed with a whole lesion measurement using a histogram approach. TIL- and vimentin-expression was calculated on bioptic samples before any form of treatment. P16 staining was used to define HPV-status.

Results
Tumor-stroma ratio correlated with entropy derived from Ktrans (r = − 0.52, p = 0.0071) and with kurtosis derived from Ve (r = − 0.53, p = 0.0058).
Several Ve derived parameters correlated with expression of TIL within the stroma compartment. TIL within the tumor compartment correlated with entropy derived from Ktrans (r = 0.39, p = 0.047), p90 derived from Ve (r = 0.41, p = 0.036) and skewness derived from Ve (r = 0.41, p = 0.037). Furthermore, these associations were different between HPV positive and negative tumors.

Conclusions
DCE-MRI might be able to reflect tumor compartments and TIL expression in HNSCC. The most promising parameters were values derived from Ktrans and Ve.
Geochemical characteristics of back-arc basin lower crust and upper mantle at final spreading stage of Shikoku Basin: an example of Mado Megamullion
Authors: Akizawa Norikatsu , Ohara Yasuhiko , Okino Kyoko , Ishizuka Osamu , Yamashita Hiroyuki , Machida Shiki , Sanfilippo Alessio , Basch Valentin , Snow Jonathan E. , Sen Atlanta , Hirauchi Ken-ichi , Michibayashi Katsuyoshi , Harigane Yumiko , Fujii Masakazu , Asanuma Hisashi , Hirata Takafumi 
Published: November 2021

AbstractThis paper explores the evolutional process of back-arc basin (BAB) magma system at final spreading stage of extinct BAB, Shikoku Basin (Philippine Sea) and assesses its tectonic evolution using a newly discovered oceanic core complex, the Mado Megamullion. Bulk and in-situ chemical compositions together with in-situ Pb isotope composition of dolerite, oxide gabbro, gabbro, olivine gabbro, dunite, and peridotite are presented. Compositional ranges and trends of the igneous and peridotitic rocks from the Mado Megamullion are similar to those from the slow- to ultraslow-spreading mid-ocean ridges (MOR). Since the timing of the Mado Megamullion exhumation corresponds to the very end of the Shikoku Basin opening, the magma supply was subdued and highly episodic, leading to extreme magma differentiation to form ferrobasaltic, hydrous magmas. In-situ Pb isotope composition of magmatic brown amphibole in the oxide gabbro is identical to that of depleted source mantle for mid-ocean ridge basalt (MORB). In the context of hydrous BAB magma genesis, the magmatic water was derived solely from the MORB source mantle. The distance from the back-arc spreading center to the arc front increased away through maturing of the Shikoku Basin to cause MORB-like magmatism. After the exhumation of Mado Megamullion along detachment faults, dolerite dikes intruded as a post-spreading magmatism. The final magmatism along with post-spreading Kinan Seamount Chain volcanism were introduced around the extinct back-arc spreading center after the opening of Shikoku Basin by residual mantle upwelling.
The differential for chest pain: when the most common cause is not the answer-a case of de novo esophageal bezoar
Authors: Climaco Kevin , Roubik Daniel , Gorrell Robert 
Published: November 2021

Abstract
Background
Having a broad differential and knowing how to manage the different possibilities in a patient with chest pain is important. Esophageal bezoars are rare entities and are even less common in patients without any recent hospitalizations, known achalasia, or nasogastric tubes. Despite their rarity, having it in one’s differential, and knowing how to manage it is important.

Case presentation
This case presents a patient with mega-esophagus secondary to an esophageal bezoar; and runs through the gamut of morbid chest pathophysiology, its differential, work-up, and management. The case is interesting in that the patient’s initial presentation brings to mind a bevy of feared chest issues to include myocardial infarction, dissection, pulmonary embolus, achalasia, and perforation.

Conclusion
This clinical case highlights more than just the rare diagnosis of esophageal bezoar. It also goes through initial resuscitation, key concerns, “can’t miss diagnoses”, and finally discusses the feared end state of an esophageal perforation.
“PPI? That sounds like Payment Protection Insurance”: Reflections and learning from a substance use and homelessness study Experts by Experience group
Authors: Foster Rebecca , Carver Hannah , Wallace Jason , Dunedin Alex , Burridge Stan , Foley Philip , Pauly Bernie , Parkes Tessa 
Published: November 2021

Abstract
Background
Patient and Public Involvement in research is important for citizenship, accountability and transparency, and has the practical benefit of helping to ensure its quality and applicability. Involving members of the public in research is becoming increasingly commonplace, in the UK and internationally. It is essential that public involvement is inclusive of individuals and their diverse life experiences, including challenging experiences that may be associated with stigma and social exclusion. The involvement of people with lived/living experience of substance use and homelessness in research is increasing in response to increased recognition of the importance of inclusion and the benefits conferred to research.

Main body
In this commentary, we share our own experiences of being part of a Patient and Public Involvement group that was convened during a feasibility study of a peer-delivered harm reduction intervention. We are a diverse group but share experience of the field of substance use/homelessness, as people with lived/living experience, and as researchers and practitioners. We share our reflections and learning, as well as offer recommendations for researchers working in our field. Our group worked together to make a positive and deliberate contribution to the study. This did not happen by chance but required the development of mutual trust and respect, with each member having a commitment to support the group for its two-year duration.

Short conclusion
It is important for researchers to appreciate that meaningful Patient and Public Involvement is very valuable but requires a commitment from all involved. Regarding our field of substance use and homelessness specifically, it is essential that people with these experiences have opportunities to contribute to research and can do so in a meaningful way. People with lived/living experience are able to bring to life the rich tapestry of others’ experiences. However, the involvement must be neither tokenistic nor indifferent to the wider challenges common to these experiences.
A case of Sphingomonas paucimobilis causing peritoneal dialysis-associated peritonitis and review of the literature
Authors: Kinoshita Chiharu , Matsuda Koichi , Kawai Yumiko , Hagiwara Takayuki , Okada Akane 
Published: November 2021

Abstract
Background
Peritoneal dialysis (PD)-associated peritonitis caused by Sphingomonas paucimobilis (S. paucimobilis) is very rare, and most of the characteristics of such cases are still unknown.

Case presentation
An 80-year-old Japanese woman on PD was diagnosed with PD-associated peritonitis and received ceftazidime and cefazolin. The number of cells in the peritoneal dialysate decreased quickly. However, because S. paucimobilis was detected, the antibiotic was changed to meropenem according to the susceptibility test results. She was treated with meropenem for two weeks and discharged. After 21 days, she was hospitalized for relapsing peritonitis. S. paucimobilis was detected again, and improvement after the administration of meropenem was poor, eventually resulting in catheter removal.

Conclusions
S. paucimobilis may be resistant to empirical antibiotics; furthermore, catheter removal may still be required, even with sensitive-antibiotic treatment.
Deficits in central auditory processing among migraine patients
Authors: Tawfik Somia , Amin Randa , Ibrahim Sahar , Rahman Tayseer Taha Abdel 
Published: November 2021

AbstractBackgroundMigraine is a neurological disease associated with abnormal excitability in visual, somatosensory, and motor cortex. This study aimed to verify and compare auditory processing performance in migraine patients with and without dizziness and healthy controls.ResultsSixty subjects were divided into 3 groups: control group, twenty normal healthy subjects, and study group I (twenty subjects diagnosed with migraine) and study group II (twenty subjects diagnosed with vestibular migraine). They were evaluated using the Central Auditory Processing Questionnaire for adults, tympanometry, pure tone audiometry, Psychophysical Central Auditory Tests, including Arabic Speech Intelligibility in Noise Test for adults, Arabic Dichotic Digit Test [version II], Gap in Noise Test, Duration Pattern Test, and Arabic Memory Tests. No significant difference was found between the two study groups I and II, but the significant difference was found between the study groups and the control group in all central auditory test results. Statistically significant difference was found between the control group and study groups I and II regarding all memory tests. The highest percentage of abnormality was present in temporal resolution and selective auditory attention in both study groups. There was no significant statistical correlation between the number of attacks/month and central auditory test results. There was no significant statistical correlation between the frequency of attacks in VM patients and central auditory test results.ConclusionsPatients with migraine and vestibular migraine had an inferior performance in all psychophysical central auditory tests when compared with control. Also, there was no significant difference between the 2 study groups regarding central auditory test results which may support that both migraine with and without dizziness have the same pathophysiology.
Prognosis Comparison Between Nipple-Sparing Mastectomy and Total Mastectomy in Breast Cancer: A Case-Control Study After Propensity Score Matching
Authors: Fu Mengdie , Chen Qitong , Zeng Liyun , Hong Tao , Zou Qiongyan , Yuan Yunchang , Yi Wenjun 
Published: November 2021

Abstract
Background
Currently, the operation rate of nipple-sparing mastectomy (NSM) is increasing. However, the long-term prognosis of NSM is not well documented. We utilized the Surveillance, Epidemiology, and End Results (SEER) database to analyze the long-term prognosis of NSM compared with total mastectomy (TM).

Methods
Population-level data of female breast cancer patients treated with NSM and TM were extracted from 1998 to 2016 from the SEER database. Propensity score matching (PSM) was performed to reduce the influence of selection bias and confounding variables in comparisons. Kaplan-Meier analysis, log-rank test, and Cox proportional hazard regression were performed.

Results
A total of 5765 patients underwent NSM, which increased from 266 in 2004–2009 to 5370 in 2010–2016. A total of 134,528 patients underwent TM, and the number of patients undergoing TM continued to decline. The overall survival (OS) and breast cancer-specific survival (BCSS) were similar between the NSM group and the TM group (P = 0.058 and 0.87, respectively). For OS, subgroup analysis showed that patients with age ≥ 46, White race, median household income ≥ $70,000, hormone receptor-positive, and HER2 negative had a better prognosis for treatment with NSM. There was no significant difference in BCSS between the NSM group and the TM group.

Conclusions
In recent years, the clinical application of NSM has been increasing. NSM is a proper procedure for breast cancer patients to achieve long-term survival.
Impact of convex ostomy appliances on leakage frequency, peristomal skin health and stomal protrusion
Authors: González Eugenia Rodriguez , Zurita Carmen del Pino , Caballero Gemma Arrontes , Rodríguez Araceli Hoyo , Rodríguez Eugenia Zapatero , Blázquez Eduardo García 
Published: November 2021

Aim: The Convexity in Ostomy (ECOS) study measured the impact of soft convex ostomy appliances on leakage frequency, peristomal skin health, and patient satisfaction, as well as stomal protrusion and body profile. Methods: This prospective non-randomised controlled trial included people with a stoma, divided into a control group using a convex appliance throughout (Alterna Confort Convex or Easiflex Confort Convex Light, Coloplast A/S, Humlebæk, Denmark), and an intervention group who were using a flat appliance at baseline before switching to a convex appliance for the rest of the study. Leakage frequency was counted within the past 2 weeks; peristomal skin health was assessed using the discolouration, erosion and tissue overgrowth (DET) Ostomy Skin Tool; and patient satisfaction was measured with a 0-10 Likert scale of self-reported satisfaction with the appliance. Measurements were taken at three visits: baseline (V1), 2-8 weeks (V2) and 6 months (V3). The Kruskal-Wallis and analysis of variance (ANOVA) tests were used for comparison. Multiple regression analysis was used to evaluate the effect of independent variables on the change in leakage frequency and DET score between baseline and 6 months. Findings: Of 253 participants screened, 245 completed the follow-up, with 151 in the intervention group and 94 in the control group. Mean leakage frequency period went from 5.85 ± 5.55 (V1) to 0.63 ± 1.42 (V2) and 0.23 ± 0.75 (V3) (p<.0001). Mean DET score changed from 4.8 ± 3.47 (V1) to 1.41 ± 2.17 (V2) and 0.54 ± 1.57 (V3) (p<.0001). Mean satisfaction changed from 6.0 ± 2.25 (V1) to 8.6 ± 1.14 (V2) and 9.17 ± 0.93 (V3) (p<.0001). From V1 to V3, the proportion of patients with a depressed peristomal area went from 45.7% to 31.4%, a normal peristomal area went from 45.3% to 65.3%, stoma protrusion went from 31.4% to 47.3% and stoma retraction went from 28.6% to 15.5%. By group, mean leakage frequency decreased in the intervention group by 7.65, from 7.57 to 0.11, and in the control group by 2.37, from 2.94 to 0.46 (p<0.0001). Multiple ANOVA analysis confirmed independent variables in reducing leakage to be initiating convexity and appliance coupling. By group, mean DET score decreased in the intervention group by 4.82, from 5.24 to 0.42, and in the control group by 3.52, from 4.34 to 0.76. Multiple ANOVA analysis showed independent variables for DET score to be initiating convexity, emergency surgery and stoma siting. Conclusion: People with a stoma experiencing repeated leakage benefitted from shifting from a flat to a soft convex appliance in terms of leakage frequency, peristomal skin health, stomal protrusion and body profile.
The light intensity mediates the pollination efficacy of a Caatinga morning glory Ipomoea bahiensis (Convolvulaceae)
Authors: Gimenes Miriam , Araujo Laene Silva , Medina Anderson Matos 
Published: November 2021

Pollination is an ecological process that relies on the matching traits of flower visitors and flowers. Morphology, behavior, and temporal patterns play essential roles in mediating the interactions between plants and floral visitors. This study analyzed the temporal aspects of visitors and flowers interaction and the possible adjustment between both organisms. We used Ipomoea bahiensis and its flower visitors as a model system. We evaluated the visitor frequency on the flowers throughout the day, flower opening and closing times, pollen availability and stigma receptivity. We also evaluated the highest fruit production time during the flower longevity was analyzed, and the time of highest pollinator activity, related to climatic factors. Among the floral visitors, bees, especially Melitoma spp., Apis mellifera, and Pseudaugochlora pandora were the most frequent visitors, presenting regular visits synchronized with the flower opening and closing times, which were also regular. This system was influenced mainly by light intensity. Besides, these bees were very active during the times of the highest fruit production. These data indicate the presence of temporal patterns for both the bees and the visited plants, and synchronization between them, being the light intensity as a modulator of the rhythms of bees and plant, confirming the importance of the temporal adjustments for pollination efficiency.
Longslit spectroscopy of the peculiar Seyfert 2 galaxy HRG 10103
Authors: Poppe Paulo C.R. , Martin Vera A.F. , Faúndez-Abans Max , De Oliveira-Abans Mariângela , De Fernandes Iranderly F. 
Published: November 2021

We present the rst optical longslit spectroscopy for the galaxy HRG 10103, an Sa(r) type peculiar galaxy seen face-on with an asymmetrical elliptical structure. The main goal of this work is to provide the spectral classication of the current object using the `traditional' diagnostic diagrams. However, we also present a diagnostic involving the known emission line ratio R23, usually used to estimate the O/H abundance ratio. The idea is to make a better distinction between the narrow-line AGNs and the H II galaxies. The spectra were obtained in two observatories (OPD-LNA/MCT and Gemini-South) and includes some of the most important emission lines for ionization diagnostic. Based on the observed spectra, HRG 10103 is a Seyfert 2 galaxy with typical line-ratios values in the optical range. We have estimated nuclear redshift of z = 0.039. The resulting reddening values as a function of distance from the nucleus are presented too. The errors in the fluxes were mostly caused by uncertainties in the placement of the continuum level. The rotation curve is typical of spiral disks, rising shallowly and attening at an observed amplitude of about 200 km s^(-1). Some other physical parameters have been derived whenever possible. The spectroscopic data reduction was carried out using the GEMINI.GMOS package as well as the standard IRAF procedures.
Longslit spectroscopy of the starburst galaxy HRG 02401
Authors: Martin Vera A.F. , Poppe Paulo C.R. , Faúndez-Abans Max , De Oliveira-Abans Mariângela , De Fernandes Iranderly F. 
Published: November 2021

We investigate in detail the kinematics and morphology of the starburst galaxy HRG 02401. Our observational data were obtained at the 1.6-m OPD/LNA-MCT telescope with longslit spectroscopy. The original image has been enhanced to highlight some substructures and it has shown that HRG 02401 is in phase of active merging with a companion galaxy. The resulting tidal perturbations may have induced the apparent two-armed spiral pattern and driven a substantial fraction of disc gas inwards. We have been able to study the detailed picture of ionized gas motions up to galactocentric distances of 11 kpc and to construct the stellar velocity field for the inner region. Although the optical ring is quite narrow, H(alpha) emission is observed all the way through the center of the galaxy, indicating the presence of an extended gaseous disk. We have estimated nuclear redshift of z = 0.017, corresponding to a heliocentric velocity of 5,206 \pm 13.01 km s(-1). The errors in the fluxes were mostly caused by uncertainties in the placement of the continuum level. Some other physical parameters have been derived whenever possible. All spectra were reduced and analyzed in a homogeneous way with the standard IRAF procedures.
Noda Interpropositional Modality
Authors: Rini Elizabeth Ika Hesti Aprilia Nindia 
Published: November 2021

Noda has an explanation function. The research aims to describe the structure and meaning of noda modality as interpropositional modalitiy. The data were obtained from Japanese website, such as asahi.com, ameba.jp, aozora.gr.jp, yourei.jp, and context.reverso.net. The data collection method in this research is the simak and catat method. Then, using qualitative descriptive method to analysis the structure and meaning of noda modality, while the agih method is used to find out noda modality.’s usage The data presentation stage use informal techniques. Based on data analysis, it is concluded that noda’s modality could be attached to verbs, i-adjectives, na-adjectives and nouns. Noda as an interpropositional modality has two types; “related types” (kankeidzuke) and “unrelated types” (hikankeidzuke), and each types have its meaning.
Long-term within- and between-subject biological variation of 29 routine laboratory measurands in athletes
Authors: Diaz-Garzon Jorge , Fernandez-Calle Pilar , Aarsand Aasne K. , Sandberg Sverre , Coskun Abdurrahaman , Carobene Anna , Jonker Niels , Itkonen Outi , Bartlett William A. , Buno Antonio 
Published: November 2021

Abstract

Objectives
Within- and between-subject biological variation (BV) estimates have many applications in laboratory medicine. However, robust high-quality BV estimates are lacking for many populations, such as athletes. This study aimed to deliver BV estimates of 29 routine laboratory measurands derived from a Biological Variation Data Critical Appraisal Checklist compliant design in a population of high-endurance athletes.

Methods
Eleven samples per subject were drawn from 30 triathletes monthly, during a whole sport season. Serum samples were measured in duplicate for proteins, liver enzymes, lipids and kidney-related measurands on an Advia2400 (Siemens Healthineers). After outlier and homogeneity analysis, within-subject (CVI) and between-subject (CVG) biological variation estimates were delivered (CV-ANOVA and log-ANOVA, respectively) and a linear mixed model was applied to analyze the effect of exercise and health related variables.

Results
Most CVI estimates were similar or only slightly higher in athletes compared to those reported for the general population, whereas two- to three-fold increases were observed for amylase, ALT, AST and ALP. No effect of exercise and health related variables were observed on the CVI estimates. For seven measurands, data were not homogeneously distributed and BV estimates were therefore not reported.

Conclusions
The observation of higher CVI estimates in athletes than what has been reported for the general population may be related to physiological stress over time caused by the continuous practice of exercise. The BV estimates derived from this study could be applied to athlete populations from disciplines in which they exercise under similar conditions of intensity and duration.