bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cigarette Promotions in U.S. Pharmacies
Authors: Seidenberg Andrew B , Henriksen Lisa , Ribisl Kurt M 
Published: October 2021

Abstract

Introduction
The sale of tobacco products within American pharmacies has generated controversy for several decades, leading two U.S. states and 45 municipalities to adopt tobacco-free pharmacy policies. While previous research has reported cheaper cigarette prices in pharmacies, compared to other retailers, little is known about cigarette promotions in pharmacies, which are associated with increased youth smoking and unplanned cigarette purchases among adults.

Aims and Methods
Between May and August 2015, trained data collectors conducted store audits at 2128 tobacco retailers located within 97 U.S. counties in 40 states. Observations were made for three types of cigarette promotions: special price (e.g., $0.30 off/pack), multi-pack promotions (e.g., buy one pack, get one free), and cross-product promotions (e.g., buy a pack of cigarettes and a get free can of snus). We calculated weighted estimates of the proportion of pharmacies and other retailer types with cigarette promotions and used weighted multivariable logistic regression to compare cigarette promotions by tobacco retailer type, accounting for clustering at the county level and controlling for county-level demographic characteristics.

Results
Cigarette promotions were observed in 94.0% of pharmacies, more than any other retailer type (e.g., convenience stores: 82.0%, tobacco stores: 77.0%). All retailer types had lower odds of promotions for Marlboro, Newport, Camel, menthol, or any interior cigarette promotion, compared to pharmacies.

Conclusions
Nearly all pharmacies offered in-store cigarette promotions and pharmacies had greater odds of offering cigarette promotions than all other retailer types. Whether voluntarily or legislatively, tobacco-free pharmacies would eliminate a prevalent retail source of cigarette promotions.

Implications
This is the first known national study to examine prevalence of cigarette promotions in U.S. pharmacies compared to other retailer types. Nearly all pharmacies offered in-store cigarette promotions and pharmacies had greater odds of offering cigarette promotions than all other retailer types. These findings underscore the inherent contradiction of pharmacies serving both as an important component of the health care system, but also as purveyors and promotors of addictive and lethal tobacco products. Whether voluntarily or legislatively, tobacco-free pharmacy policies would eliminate a prevalent retail source of cigarette promotions.
Subaru/FOCAS IFU revealed the metallicity gradient of a local extremely metal-poor galaxy
Authors: Kashiwagi Yuri , Inoue Akio K , Isobe Yuki , Nakajima Kimihiko , Ouchi Masami , Ozaki Shinobu , Fujimoto Seiji , Ono Yoshiaki , Kojima Takashi 
Published: October 2021

Abstract
We present the first measurement of the metallicity gradient in extremely metal-poor galaxies (EMPGs). With Subaru/Faint Object Camera And Spectrograph (FOCAS) Integral Field Unit (IFU), we have observed a nearby, low-mass EMPG, HSC J1631+4426, whose oxygen abundance and stellar mass are known to be 12 + log (O/H) = 6.9 and log10(M*/M⊙) = 5.8, respectively. The measured metallicity gradient is −0.36 ± 0.04 dex kpc−1 corresponding to −0.049 ± 0.006 dex$\:R_\mathrm{e}^{-1}$ for the continuum effective radius of Re = 0.14 kpc. Our observation has successfully demonstrated that three-dimensional spectroscopy with 8 m-class telescopes is powerful enough to reveal the metallicity distribution in local EMPGs, providing precious information on the baryon cycle in local analogs of primordial galaxies in the early Universe.
The Effect of the Model’s Social Status on Placebo Analgesia Induced by Social Observational Learning
Authors: Bieniek Helena , Bąbel Przemysław 
Published: October 2021

Abstract

Background
Placebo analgesia can be induced by social observational learning. The aim of this study was to determine whether this effect can be influenced by the social status of a model.

Methods
Healthy volunteers were randomly assigned to three groups: a group that observed a video featuring a high-status model (introduced as a professor), a group that observed a video featuring a low-status model (introduced as a janitor), and a control group. Participants observed videos showing a model (of high or low status) undergoing the experimental procedure, during which he received pain stimuli. In each group, half of participants watched a video in which the model rated blue stimuli as more painful (6–8 on the numeric rating scale) and orange stimuli as less painful (1–3 on the numeric rating scale), whereas the other half of participants watched a video in which the model rated orange stimuli as more painful and blue stimuli as less painful. Participants in the control group did not watch any video. Then, all participants received 16 electrocutaneous pain stimuli of the same intensity, preceded by either blue or orange colors. The perceived social status of the model and the trait empathy of participants were measured.

Results
Placebo analgesia was induced in both experimental groups, yet no difference in the magnitude of the effect was found. However, we found that the participants’ individual ratings of the model’s social status predicted the magnitude of placebo analgesia.

Conclusion
This is the first study to show that the perception of a model’s social status is related to the magnitude of placebo analgesia induced by observational learning.
Functional and Structural Neuroplastic Changes Related to Sensitization Proxies in Patients with Osteoarthritis: A Systematic Review
Authors: Pedersini Paolo , Gobbo Massimiliano , Bishop Mark D , Arendt-Nielsen Lars , Villafañe Jorge H 
Published: October 2021

Abstract

Objective
Several reports in literature have identified sensitization as a possible basis for the enhanced pain reactions associated with osteoarthritis (OA). The aim of this current systematic review is to summarize functional and structural brain changes associated with surrogate sensitization parameters assessed in patients with OA-related pain.

Design
Systematic review.

Subjects
Patients with OA related pain.

Methods
A literature search was conducted systematically in MEDLINE, CINAHL, EMBASE databases for human studies up to December 2019. Articles were included if they assessed brain imaging and sensitization parameters (quantitative sensory testing and questionnaires) in adults with OA-related pain. Methodological quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS) score.

Results
Five studies reporting on 138 patients were included in this review. The MINORS scale yielded mean scores of 8.5/16 and 12.3/24, for the cohort and case-control studies respectively. Four low-quality studies suggest a greater pain matrix activation associated with clinical measures of sensitization in patients with OA, while another study underlined the presence of structural changes (reduced gray matter volume) in the cortical areas involved in the nociceptive processing possible also related to sensitization.

Conclusions
This review shows conflicting evidence for structural and functional neuroplastic brain changes related to sensitization proxies in patients with OA.
The Greater London Council’s Homesteading Scheme: Housing Rehabilitation and the Urban Imaginary of Conservative Politics in London, 1977–81
Authors: Pinto Tessa 
Published: October 2021

Abstract
This article examines the Greater London Council (GLC)’s Homesteading scheme, which gave away dilapidated, council-owned houses to aspiring homeowners. The first section provides an overview of the scheme and its North American origins. The second half of the article explores the scheme in the context of London’s electoral geopolitics, and considers how the relationship between the boroughs and the GLC influenced housing policy across the capital. The article then locates the scheme within the context of the ‘inner city’, and explores the complex relationship between race, homeownership, and the Conservative Party during the late 1970s. Finally, the article identifies the formation of a Conservative urban imaginary that envisioned London as a ‘city of villages’, resurrecting the brick terraced street as the ideal domestic form, in opposition to the high-rise housing of welfare state modernism—and in so doing, drew on a growing sense of popular individualism during the decade. To conclude, the article proposes that the GLC’s Homesteading scheme was a striking prefiguration of the kinds of urban interventions in British cities that characterized Thatcher’s premiership, and that it has significance for understanding a range of diverse, intersecting urban issues during the period.
LncRNA-ENST00000556926 regulates the proliferation, apoptosis and mRNA transcriptome of malignant-transformed BEAS-2B cells induced by coal tar pitch
Authors: Zhu Yonghang , Li Zhongqiu , Wang Weiguang , Jing Linhao , Yu Qi , Li Zhenkai , Chen Xu , Zhang Jiatong , Zhang Peng , Feng Feifei , Zhang Qiao 
Published: October 2021

Abstract
As a byproduct of coal tar distillation, coal tar pitch (CTP) has been proven to be carcinogenic to human. However, the mechanisms of lung cancer induced by CTP are still unclear. It has been shown that long non-coding RNAs (LncRNAs) play an important role in the development of human cancers. This study aims to investigate the effect of LncRNA-ENST00000556926 on malignant-transformed human bronchial epithelial (BAES-2B) cells induced by coal tar pitch extracts (CTPE). In this study, BEAS-2B cells were treated with 2.4 μg/ml of CTPE for 72 h and then passaged; and the cells were treated 4 times in the same procedure, then passaged until passage 30 (CTPE30). Cell counting kit-8 (CCK-8) assay was used to detect cell viability, then cell cycle and apoptosis were analyzed by flow cytometry, and transcriptome sequencing analysis was used to detect differentially expressed mRNAs after interference of ENST00000556926. The results indicated that the expression of ENST00000556926 in CTPE30 group was significantly higher compared with control group. Furthermore, after interfering the expression of ENST00000556926, cell viability was inhibited, and cell cycle was arrested while apoptosis of malignant-transformed BEAS-2B cells was promoted. Moreover, a total of 159 differentially expressed mRNAs were screened out after interference of ENST00000556926, including 62 up-regulated mRNAs and 97 down-regulated mRNAs. In addition, knockdown of ENST00000556926 decreased the expression of thioredoxin domain containing 5 (TXNDC5) and FOXD1. In conclusion, LncRNA-ENST00000556926 could regulate the proliferation, apoptosis and mRNA transcriptome of malignant-transformed BEAS-2B cells induced by CTP, which may provide a novel treatment strategy for lung cancer.
Growth Promotion of Giant Duckweed Spirodela polyrhiza (Lemnaceae) by Ensifer sp. SP4 Through Enhancement of Nitrogen Metabolism and Photosynthesis
Authors: Toyama Tadashi , Mori Kazuhiro , Tanaka Yasuhiro , Ike Michihiko , Morikawa Masaaki 
Published: October 2021

Duckweeds (Lemnaceae) are representative producers in fresh aquatic ecosystems and also yield sustainable biomass for animal feeds, human foods, and biofuels, and contribute toward effective wastewater treatment; thus, enhancing duckweed productivity is a critical challenge. Plant-growth-promoting bacteria (PGPB) can improve the productivity of terrestrial plants; however, duckweed–PGPB interactions remain unclear and no previous study has investigated the molecular mechanisms underlying duckweed–PGPB interaction. Herein, a PGPB, Ensifer sp. strain SP4, was newly isolated from giant duckweed (Spirodela polyrhiza), and the interactions between S. polyrhiza and SP4 were investigated through physiological, biochemical, and metabolomic analyses. In S. polyrhiza and SP4 coculture, SP4 increased the nitrogen (N), chlorophyll, and ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) contents and the photosynthesis rate of S. polyrhiza by 2.5-, 2.5-, 2.7-, and 2.4-fold, respectively. Elevated photosynthesis increased the relative growth rate and biomass productivity of S. polyrhiza by 1.5- and 2.7-fold, respectively. Strain SP4 significantly altered the metabolomic profile of S. polyrhiza, especially its amino acid profile. N stable isotope analysis revealed that organic N compounds were transferred from SP4 to S. polyrhiza. These N compounds, particularly glutamic acid, possibly triggered the increase in photosynthetic and growth activities. Accordingly, we propose a new model for the molecular mechanism underlying S. polyrhiza growth promotion by its associated bacteria Ensifer sp. SP4, which occurs through enhanced N compound metabolism and photosynthesis. Our findings show that Ensifer sp. SP4 is a promising PGPB for increasing biomass yield, wastewater purification activity, and CO2 capture of S. polyrhiza. [Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Integration of Patient-reported Outcomes Assessment Into Routine Care for Patients Receiving Residential Treatment for Alcohol and/or Substance Use Disorder
Authors: Yi Cameron M. , Huhn Andrew S. , Hobelmann J. Gregory , Finnerty John , Solounias Bernadette , Dunn Kelly E. 
Published: October 2021

Background
More than 3 million individuals receive treatment for alcohol use disorder (AUD) and/or substance use disorder each year, yet there exists no standardized method for measuring patient success in treatment. Quantifying a more comprehensive assessment of treatment outcomes could identify the relative efficacy of different treatment strategies for individuals with AUD/substance use disorders, and help patients to identify, in advance, appropriate treatment options.

Methods
This study developed and embedded patient-reported outcome measures into the routine clinical operations of a residential treatment program. Surveys assessed demographics, drug use history, physical and mental health, and quality of life. Outcomes were assessed among participants at admission (n = 961) and in patients who completed the survey at time of discharge (n = 633).

Results
Past 30-day alcohol and/or opioid use at admission were correlated with worse self-reported physical and mental health, sleep, and quality of life, and greater negative affect and craving (Ps < 0.05). Previous history of treatment and/or withdrawal management were associated with worse self-reported physical and mental health, quality of life, and increased craving (Ps < 0.05). Physical and mental health improved across timepoints and was most pronounced when comparing persons receiving treatment for opioid use disorder versus AUD, wherein persons with opioid use disorder had worse physical health at all time points, and greater sleep disturbance and negative affect at discharge (Ps < 0.05).

Conclusions
It is feasible to embed patient outcome monitoring into routine clinic operations, which could be used in the future to tailor treatment plans.
Single Dose of Oral Azithromycin With or Without Amoxicillin to Prevent Peripartum Infection in Laboring, High-Risk Women in Cameroon
Authors: Subramaniam Akila , Ye Yuanfan , Mbah Rahel , Mbunwe Doreen M. , Pekwarake Seraphine , Bunwi Edwan Yui , Fondzeyuf Anthony , Ngong Mary G. , Dionne-Odom Jodie , Harper Lorie M. , Jauk Victoria C. , Carlo Waldemar A. , Halle-Ekane Gregory , Szychowski Jeff M. , Tih Pius , Tita Alan T. 
Published: October 2021

OBJECTIVE:
To compare the effectiveness of single-dose azithromycin, with or without amoxicillin, with placebo to prevent peripartum infection in laboring women.

METHODS:
We conducted a multicenter, three-group, double-blind randomized controlled trial of women with viable term nonanomalous pregnancies with either prolonged labor of 18 hours or longer or rupture of membranes for 8 hours or longer in Cameroon. Women with chorioamnionitis before randomization, study drug contraindications, or planned cesarean births were excluded. Women were randomized to oral azithromycin 1 g–placebo (group 1), oral azithromycin 1 g–oral amoxicillin 2 g (group 2), or placebo–placebo (group 3). All groups received usual care, including antibiotics given at the health care professional's discretion. The primary outcome was a composite of maternal peripartum infection or death from any cause up to 6 weeks postpartum. Two primary comparisons (group 1 vs group 3 and group 2 vs group 3) were planned. We estimated that 241 women per group (planning for 750 total) would provide 80% power at two-sided α=0.05 (0.025 per comparison) to detect a 50% effect size assuming 20% baseline composite infection rate.

RESULTS:
From January 6, 2018, to May 15, 2020, 6,531 women were screened, and 756 (253 in group 1, 253 in group 2, and 250 in group 3) were randomized. Baseline characteristics (including body mass index, duration of rupture of membranes or labor, and parity) were balanced across groups, except for maternal age. More than 60% of women in each group received usual-care antibiotics: more than 90% penicillin and approximately 50% for prolonged rupture of membranes across all study groups. Composite outcome incidences were similar in antibiotic groups 1 (6%) and 2 (7%) compared with placebo group 3 (10%) (RR 0.6, 95% CI 0.3–1.2; 0.7, 95% CI 0.4–1.3, respectively). Chorioamnionitis and wound infection were significantly lower in group 2 (3.2% vs 0.4% and 4% vs 0.8% respectively, both P=.02) compared with group 3. There were no differences in other maternal or neonatal outcomes including neonatal infection.

CONCLUSION:
A single dose of oral azithromycin with or without amoxicillin for prolonged labor or rupture of membranes at term did not reduce maternal peripartum or neonatal infection. Observed lower than expected infection rates and frequent usual-care antibiotic use may have contributed to these findings.

CLINICAL TRIAL REGISTRATION:

ClinicalTrials.gov, NCT03248297.

FUNDING SOURCE:
Merck for Mothers Investigator Studies Program grant.
Birth Outcomes for Planned Home and Licensed Freestanding Birth Center Births in Washington State
Authors: Nethery Elizabeth , Schummers Laura , Levine Audrey , Caughey Aaron B. , Souter Vivienne , Gordon Wendy 
Published: October 2021

OBJECTIVE:
To describe rates of maternal and perinatal birth outcomes for community births and to compare outcomes by planned place of birth (home vs state-licensed, freestanding birth center) in a Washington State birth cohort, where midwifery practice and integration mirrors international settings.

METHODS:
We conducted a retrospective cohort study including all births attended by members of a statewide midwifery professional association that were within professional association guidelines and met eligibility criteria for planned birth center birth (term gestation, singleton, vertex fetus with no known fluid abnormalities at term, no prior cesarean birth, no hypertensive disorders, no prepregnancy diabetes), from January 1, 2015 through June 30, 2020. Outcome rates were calculated for all planned community births in the cohort. Estimated relative risks were calculated comparing delivery and perinatal outcomes for planned births at home to state-licensed birth centers, adjusted for parity and other confounders.

RESULTS:
The study population included 10,609 births: 40.9% planned home and 59.1% planned birth center births. Intrapartum transfers to hospital were more frequent among nulliparous individuals (30.5%; 95% CI 29.2–31.9) than multiparous individuals (4.2%; 95% CI 3.6–4.6). The cesarean delivery rate was 11.4% (95% CI 10.2–12.3) in nulliparous individuals and 0.87% (95% CI 0.7–1.1) in multiparous individuals. The perinatal mortality rate after the onset of labor (intrapartum and neonatal deaths through 7 days) was 0.57 (95% CI 0.19–1.04) per 1,000 births. Rates for other adverse outcomes were also low. Compared with planned birth center births, planned home births had similar risks in crude and adjusted analyses.

CONCLUSION:
Rates of adverse outcomes for this cohort in a U.S. state with well-established and integrated community midwifery were low overall. Birth outcomes were similar for births planned at home or at a state-licensed, freestanding birth center.
Speech Audiometrical Results Before and After Reimplantation of Cochlear Implants
Authors: Öz Okan , De Ceulaer Geert , Govaerts Paul J. 
Published: October 2021

Objectives:
This study aimed to compare the audiological outcomes of cochlear reimplantation with those of the first cochlear implant (CI).

Design:
A retrospective analysis was performed on the data of all CI recipients who received the first CI at the age of 8 years or above and who were subsequently reimplanted on the same side. All participants who received their first implant after January 1, 2000, and who were reimplanted before January 1, 2021, were included. CI recipients who were unable to perform an open-set of Flemish monosyllable speech audiometry were excluded. The participants’ clinical files were reviewed in terms of the cause of hearing loss, age at the first and second implantation, device types, the time between the first and second surgery, speech reception scores before and after reimplantation, and the reason for reimplantation.

Results:
Reimplantation was due to device failure in 19 out of 22 patients, performance decrement in two patients, and medical reasons in one patient. The interval between the first and second CI ranged from 8 to 218 mo. Within-subject analysis showed the speech reception performance with the second CI to be significantly better than that with the first CI at all follow-up time points, with average within-patient gains of 17%, 16%, 12%, and 15% at 3 mo, 9 mo, 3 years, and the highest scores achieved, respectively. After reimplantation, the performance was better than the last results before reimplantation, and this was significant from 9 mo after reimplantation onwards. Three patients (14%) had a performance degradation with the second CI, which was probably owing to (1) difficulties in reimplantation surgery leading to a reduced number of active channels, (2) insufficient experience with the second CI as the reimplantation has been performed recently, and (3) advanced fenestral and retrofenestral otosclerosis.

Conclusions:
The present study shows that speech reception performance after reimplantation yields faster and better results than the first implant. It takes a couple of months to get better results than those before the reimplantation. Only in a minority of participants, a small deterioration may be observed. It seems that soft failures in the absence of measurable technical abnormalities call for caution with regard to reimplantation.