bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promotion of Instagram and Purchase Intention: A Case of Beverage Business at Covid-19 Pandemic
Authors: Habibie Fachrul Husain , Mustika Amalia , Ratnaningtyas Heny , Noveti Velicia 
Published: April 2021

This study aims to analyze the effect of Instagram promotion on buying interest at Yogo Living World. This study uses a descriptive correlational method with a quantitative approach. The unit of analysis in this study is Yogo Living World consumers with a sample size of 100 individuals using probability sampling techniques. This study uses a simple linear regression test. The results of the descriptive statistical test show that: (1) Instagram promotion is in the fairly interesting category with an average score of 3.81 and (2) purchase intention is in the fairly interesting category with an average score of 3.87. The coefficient of determination test results show that the promotion factor of Instagram has an effect of 74.1% on buying interest at Yogo Living World and the remaining 25.9% is influenced by other factors that are not examined. The t test shows that Instagram promotion has a significant effect on buying interest at Yogo Living World. The culinary business is promoted through social media, especially Instagram, which can describe product profiles ranging from taste, appearance and service through videos displayed on social media. In Instagram promotions, the hashtag indicator adds hashtag variations, the number of hashtags, and provides special promotions for customers who use hashtags.
Keywords: Promotion of Instagram, Purchase Intention, Yogo Living World
Intercultural Communication in Manuscript Digitization (Study in the Village of Legok Indramayu)
Authors: Widiyanarti Tantry , Sarwoprasodjo Sarwititi , Sihabudin Ahmad , Kinseng Rilus A. 
Published: April 2021

Manuscript digitization is an effort to preserve the content of the manuscript from damage. The content of the manuscript which contain local wisdom must be saved, because the manuscript is old and is in a concerning condition, damaged, destroyed, or even lost. Therefore, digitalization needs to be done. However, digitalization cannot be done easily, because there are cultural differences that underlie it. This study wants to see how intercultural communication is carried out during the process of digitizing a manuscript so that digitization can be carried out. This study uses a qualitative method with observation, interview, and data triangulation techniques. This research is useful to add insight and make it easier for the digitizer to digitize the manuscript if he meets a manuscript owner with a different culture than the digitizer. The result or finding is that the intercultural communication used in digitizing manuscripts uses a cultural dimension approach so that digitization can be carried out.Keywords: Manuscript digitization, power distance, uncertainty avoidance, the collectivism-short term communication ABSTRAKDigitalisasi naskah ialah upaya untuk melestarikan isi naskah dari kerusakan. Isi naskah yang berisi local wisdom harus diselamatkan,karena usia naskah sudah tua dengan kondisi yang prihatin, rusak, hancur, bahkan hilang. Karena itu digitalisasi perlu dilakukan. Namun, digitalisasi tidak dapat dilakukan dengan mudah, disebabkan ada perbedaan budaya yang mendasarinya. Penelitian ini ingin melihat bagaimana komunikasi antarbudaya yang dilakukan ketika proses digitalisasi naskah sehingga digitalisasi dapat dilakukan. Penelitian ini menggunakan metode kualitatif dengan teknik observasi, wawancara dan triangulasi data. Penelitian ini berguna menambah wawasan dan memudahkan pendigital dalam melakukan digitalisasi naskah, jika bertemu dengan pemilik naskah yang berbeda budayanya dengan pendigital. Hasil atau temuan penelitian ini adalah komunikasi antarbudaya yang digunakan dalam digitalisasi naskah menggunakan pendekatan dimensi budaya sehingga digitalisasi dapat terlaksana. Kata Kunci: Digitalisasi naskah, power distance, uncertainty avoidance, collectivism-short term orientation, low level communication
Review
Authors: Olsen Niklas 
Published: April 2021

Jan Eike Dunkhase, ed., Reinhart Koselleck/Carl Schmitt: Der Briefwechsel 1953–1983 [Reinhart Koselleck/Carl Schmitt: The correspondence 1953–1983] (Berlin: Suhrkamp Verlag, 2019), 459 pp.Sebastian Huhnholz, Von Carl Schmitt zu Hannah Arendt? Heidelberger Entstehungsspuren und bundesrepublikanische Liberalisierungsschichten von Reinhart Kosellecks “Kritik und Krise” [From Carl Schmitt to Hannah Arendt? On the Heidelbergian genesis and the West German liberalization layers of Reinhart Koselleck’s “Kritik und Krise”] (Berlin: Duncker & Humblot, 2019), 172 pp.
THE INFLUENCE OF QUARANTINE RESTRICTIONS ON THE DEVELOPMENT OF OCCUPATIONAL BURNOUT IN EDUCATORES OF HIGHER EDUCATION AL INSTITUTIONS OF UKRAINE
Authors: Stepanchuk A.P. 
Published: April 2021

Occupational burnout syndrome most often occurs among professionals of the at-risk occupations, i.e. those who work in close contact with people and have to communicate a lot and intensively with others. This group includes educational specialists (teachers, educators, psychologists), medical professionals, and sale representatives. Fatigue, weakness, lack of interest in their activities against the background of chronic stress, is well known to many people, especially workaholics, who strive to do as much as possible, resulting in emotional burnout. With the onset of the Covid-19 pandemic, burnout has taken on a different form due to isolation, fears for the lives and health of family members, and distance from workplaces and well-accustomed co-workers. Distance learning has created new challenges for teachers and students of HEIs. Study before quarantine was already complicated, given the heavy workload, the large volume of the curriculum, and the constant lack of free time. Working in such rhythm makes it difficult to maintain mental health and prevent emotional burnout. The professional activity of university educators is characterized by increased responsibility, a wide range of commitments and the need for continuous professional development. In addition to the educational process, the teacher is responsible for the implementation of methodological, organizational, educational and research work. The influence of stressors on a teacher’s health contributes to the emergence of the syndrome of occupational burnout. “Quarantine” factors influencing the development of occupational burnout can be assigned into two groups: organizational and psychological factors related to the novel special organization of work in quarantine; psychological factors associated with the new psychological features of the professional activity and their own subjective characteristics. To prevent the development of occupational burnout, psychologists recommend to take care of yourself; do not forget about rest; realistically estimate own capabilities and, accordingly, plan work and time; do not make unnecessary commitments; do not demand too much from yourself; work should bring joy.
Planejamento participativo em Geografia: contribuições de John Dewey
Authors: Bogossian Thiago , Daflon Emanoel 
Published: April 2021

A aula de Geografia é vista por muitas crianças e adolescentes como possibilidade de conhecer melhor o mundo. Nossa disciplina oferece oportunidade para aprender sobre diferentes espaços e lugares do planeta e muitos dos nossos alunos já chegam à escola com diversos questionamentos sobre esses lugares. Na maior parte das vezes suas questões são expressas por meio de perguntas, que revelam um profundo apetite de querer entender como ou por que certos fenômenos ocorrem. Baseado em pressupostos teóricos e epistemológicos do pedagogo estadunidense John Dewey que propunha uma pedagogia em que os estudantes eram agentes ativos na busca do conhecimento, o presente artigo argumenta que as perguntas e indagações dessas crianças e adolescentes podem servir como ferramenta para aproximá-las de uma etapa do processo pedagógico que é tradicionalmente reconhecida como exclusiva dos professores: o planejamento de ensino. Para tanto, revisitamos notas autoetnográficas de nossas práticas de planejamento participativo em uma escola privada de Niterói. Com esse artigo pretendemos inspirar educadores do campo da Geografia e de outros saberes para incluir melhor a voz e a participação ativa das crianças e adolescentes no processo pedagógico.
Knowledge, Attitude and Practices of Diabetic Patients about Skin Care
Authors: Alam Md Rezaul , Amin Md Nurul , Ansari MH , Rahim Md Abdur 
Published: April 2021

Background: Diabetes is now a public health problem in our country and it is steadily increasing. Skin manifestation is frequently common in diabetics. Care of skin is a part of management, where patient's role is no less than a physician, The patients' role includes perception and practice of the patients about their skin manifestation. This cross-sectional study was, therefore, undertaken to assess the knowledge, attitude and practice of diabetic patients (respondents) about their skin care.
Methods: The study was carried out in the Department of Dermatology, National Healthcare Network, Dhaka over a period of 6 months from April to September 2009. A total of 90 diabetic patients with or without skin diseases included in the study. The level of knowledge and practice was measured on a 0-4 Likert Scale.
Results: Respondents were predominantly male (60%) with mean age being 49±11.1 years. Majority (95%) of the respondents were Muslim (95%), educated (87.7%) and middle class (83.3%). Primary and secondary level educated comprised 50% of the respondents. Over 25% was graduate and higher level educated and the rest (13.3%) illiterate. About 88% of the respondents held the view that diabetic patients were more susceptible to develop skin diseases and over 75% were aware about skin manifestations in diabetics. Although majority (98.1%) had a good knowledge about what to do in case if skin manifestation arises, less than half (45%) had knowledge about how to take care of their skin (unaware about practice). Only 36% of the respondents told that changes in skin colour should often be checked as evidence of skin manifestation (good knowledge), 31.1% told sometimes to be checked (fair knowledge) and 33.3% told never to be checked (poor knowledge). Majority of the respondents categorized pruritis (85.6%), erythema (81.1%) and impetigo (80%) as skin diseases. Pigment disorder, epidermal differentiation disorder, papules and blisters were identified by around two-thirds of the diabetics. Changes in skin pigmentation, cuts and blisters were often checked by 30% of the diabetics. Changes in red spots, swelling and sensation were often checked by 10% of the respondents. Nearly three-quarters (22%) of the respondents' knowledge about skin care was highly satisfactory in terms of Likert scale, followed by 44.4% satisfactory, 17.8% more or less satisfactory, 10% grossly dissatisfactory and 5.6% poor.
Conclusion: The study concluded that diabetic patients are aware of their skin manifestation and its different forms. They also possess good knowledge about how to take care of those manifestations. But they are usually reluctant to bring it into practice.
Ibrahim Cardiac Med J 2012; 2(2): 31-36
Management of Post Infarction Ventricular Septal Defect
Authors: Paul Shimu , Islam Md Sirajul , Roy Siba Pada , Ahmed Niaz , Mina MH , Md Jalaluddin - 
Published: April 2021

Ventricular septal rupture remains an infrequent but a serious, devastating and life threating complication of acute myocardial infarction. We report a case of 74 years old man with post infarction anterior ventricular septal rupture who was successfully managed. Ventricular septal rupture was closed by artificial (gortex) patch; concomitant coronary artery bypass grafting was done. Postoperative complications included reopening for excessive bleeding, low cardiac output with high inotropic support. A rapid diagnosis, aggressive medical management and prompt surgical intervention are required to optimize survival and recovery in patients who present with septal rupture complicating myocardial infarction.
Ibrahim Cardiac Med J 2013; 3(1&2): 49-52
Efficacy of Blind Tracheal Aspirate in Comparison to Bronchoalveolar Lavage for Microbiological Diagnosis of Nosocomial Pneumonia in Patients on Ventilator
Authors: Ahsan ASM Areef , Faruq Mohammad Omar , Fatema Kaniz , Ahmed Fatema , Hassan Shakera Binte 
Published: April 2021

Background and Objectives: For diagnosis of nosocomial pneumonia in patients on ventilator, invasive procedure like bronchoscopy for microscopy and quantitative cultures of lower respiratory tract samples is useful but not always possible for potential risk of the procedure and the associated cost. The non-bronchoscopic sampling of the lower airways and quantitative cultures of tracheal aspirate may offer simple and readily available alternative to bronchoscopy with promising results. This study was done to evaluate the efficacy of blind tracheal aspirate in the microbiological diagnosis of nosocomial pneumonia occurring in intubated patients on mechanical ventilator.
Materials & Methods: This cross-sectional study was carried out in the Intensive Care Unit in the Department of Critical Care Medicine, BIRDEM Hospital, Dhaka over a period 16 months starting from January 2010 to April 2011. A total of 54 clinically diagnosed cases of nosocomial (hospital acquired) pneumonia who were on ventilator were consecutively included in the study based on predefined enrolment criteria. All the 54 cases were subjected to blind endotracheal aspirate (BTA) followed by bronchoalveolar lavage (BAL) for quantitative cultures of specimens and isolation of causative microorganisms from them.
Result: The present study showed that the mean age of the patients was 61 years (range: 24-86 years). Males were predominant in the series with male to female ratio being 7:3. Majority of the patients was haemodynamically stable as indicated by mean blood pressures, heart rate, temperature and respiratory rate. Most (83.3%) of the cases showed significant growth of microbes on culture of blind tracheal aspirates at cut-off value of 105 colony forming unit/ml (cfu/ml), while 87% of the cases exhibited positive growth on culture of bronchoalveolar lavage at cut-off value of 104 cfu/ml. Acinetobacter baumannii was the predominant organism isolated from BTA (73.3%) followed by Pseudomonas aeruginosa (33.3%). An almost similar pattern of growth was evident in BAL with more than 70% being Acinetobacter baumannii and about 30% Pseudomonas aeruginosa. C. albicans. Kiebsiella sp., E. coli, and Flavobacter were less commonly observed in either group. The Kappa test revealed a good agreement (70.7%) between the two procedures suggesting that the two diagnostic modalities are almost comparable in diagnosing pneumonia in patients admitted in ICU (p < 0.001).
Conclusion: The study concluded that the accuracy of blind tracheal aspirate and bronchalveolar lavage in the diagnosis of nosocomial pneumonia was fairly comparable. The strength of agreement between the two diagnostic modalities is also good encouraging its use instead of more invasive procedures like BAL in the diagnosis of hospital-acquired pneumonia who are on mechanical ventilator.
Ibrahim Cardiac Med J 2014; 4(2): 49-55
Potential Role of Cardiac Computed Tomography in Establishing Diagnosis of Ruptured sinus of Valsalva Aneurysm: Case Report
Authors: Ghafoor Nusrat , Siraj Nawshin , Hasan Md Sharif , Chakma Kowshik 
Published: April 2021

Ruptured Valsalva aneurysm is a rare cardiac anomaly that may be congenital or acquired, a coexisting cardiac lesion might be present. The presentation may range from an asymptomatic murmur to cardiogenic shock. Most of these cases were earlier diagnosed using echocardiography and conventional angiography. But with the availability of advanced imaging modalities like cardiac CT this condition can be accurately assessed noninvasively. The high spatial resolution of cardiac CT provides anatomical details of the aneurysm by depicting a jet of contrast materials extending from the aneurysm and adjacent cardiac chamber. We report a case of ruptured aneurysm arising from the non-coronary sinus with a fistulous track connecting the sinus with the right atrium. This case was evaluated by 32 slice cardiac MDCT (Multi detector computed tomography) imaging. This was later confirmed peroperatively.
Ibrahim Cardiac Med J 2014; 4(2): 64-67
SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis Insights
Authors: Zhou Qiao , Vadakekolathu Jayakumar , Watad Abdulla , Sharif Kassem , Russell Tobias , Rowe Hannah , Khan Almas , Millner Peter A. , Loughenbury Peter , Rao Abhay , Dunsmuir Robert , Timothy Jake , Damiani Giovanni , Pigatto Paolo D. M. , Malagoli Piergiorgio , Banfi Giuseppe , El-Sherbiny Yasser M. , Bridgewood Charlie , McGonagle Dennis 
Published: April 2021

ObjectiveBacterial and viral infectious triggers are linked to spondyloarthritis (SpA) including psoriatic arthritis (PsA) development, likely via dendritic cell activation. We investigated spinal entheseal plasmacytoid dendritic cells (pDCs) toll-like receptor (TLR)-7 and 9 activation and therapeutic modulation, including JAK inhibition. We also investigated if COVID-19 infection, a potent TLR-7 stimulator triggered PsA flares.MethodsNormal entheseal pDCs were characterized and stimulated with imiquimod and CpG oligodeoxynucleotides (ODN) to evaluate TNF and IFNα production. NanoString gene expression assay of total pDCs RNA was performed pre- and post- ODN stimulation. Pharmacological inhibition of induced IFNα protein was performed with Tofacitinib and PDE4 inhibition. The impact of SARS-CoV2 viral infection on PsA flares was evaluated.ResultsCD45+HLA-DR+CD123+CD303+CD11c- entheseal pDCs were more numerous than blood pDCs (1.9 ± 0.8% vs 0.2 ± 0.07% of CD45+ cells, p=0.008) and showed inducible IFNα and TNF protein following ODN/imiquimod stimulation and were the sole entheseal IFNα producers. NanoString data identified 11 significantly upregulated differentially expressed genes (DEGs) including TNF in stimulated pDCs. Canonical pathway analysis revealed activation of dendritic cell maturation, NF-κB signaling, toll-like receptor signaling and JAK/STAT signaling pathways following ODN stimulation. Both tofacitinib and PDE4i strongly attenuated ODN induced IFNα. DAPSA scores elevations occurred in 18 PsA cases with SARS-CoV2 infection (9.7 ± 4 pre-infection and 35.3 ± 7.5 during infection).ConclusionEntheseal pDCs link microbes to TNF/IFNα production. SARS-CoV-2 infection is associated with PsA Flares and JAK inhibition suppressed activated entheseal plasmacytoid dendritic Type-1 interferon responses as pointers towards a novel mechanism of PsA and SpA-related arthropathy.
Mucosal Invasion, but Not Incomplete Excision, Has Negative Impact on Long-Term Survival in Patients With Extramammary Paget’s Disease
Authors: Hashimoto Hiroki , Kaku-Ito Yumiko , Furue Masutaka , Ito Takamichi 
Published: April 2021

BackgroundExtramammary Paget’s disease (EMPD) sometimes spreads from the skin to mucosal areas, and curative surgical excision of these areas is challenging. The aim of this study is to analyze the impact of mucosal involvement and surgical treatment on the survival of patients with EMPD.MethodsWe conducted a retrospective review of 217 patients with EMPD. We also assessed the associations between tumor involvement in boundary areas (anal canal, external urethral meatus, vaginal introitus), prognostic factors, and survival in 198 patients treated with curative surgery.ResultsOf 217 patients, 75 (34.6%) had mucosal boundary area involvement. Lesions in these areas were associated with frequent lymphovascular invasion (p = 0.042), lymph node metastasis (p = 0.0002), incomplete excision (p &lt; 0.0001), and locoregional recurrence (p &lt; 0.0001). Boundary area involvement was an independent prognostic factor associated with disease-specific survival, per multivariate analysis (HR: 11.87, p = 0.027). Incomplete excision was not significantly correlated with disease-specific survival (HR: 1.05, p = 0.96).ConclusionBoundary area tumor involvement was a major risk factor for incomplete excision, local recurrence, and poor survival outcomes. However, incomplete removal of primary tumors was not significantly associated with poor prognosis. A less invasive surgical approach for preserving anogenital and urinary functions may be acceptable as the first-line treatment for resectable EMPD.
The LncRNA CASC11 Promotes Colorectal Cancer Cell Proliferation and Migration by Adsorbing miR-646 and miR-381-3p to Upregulate Their Target RAB11FIP2
Authors: Zhang Wei , Li Xiaomin , Zhang Wenjuan , Lu Yanxia , Lin Weihao , Yang Lawei , Zhang Zheying , Li Xuenong 
Published: April 2021

BackgroundWe previously reported that the long non-coding RNA (lncRNA) CASC11 promotes colorectal cancer (CRC) progression as an oncogene by binding to HNRNPK. However, it remains unknown whether CASC11 can act as a competitive endogenous RNA (ceRNA) in CRC. In this study, we focused on the role of CASC11 as a ceRNA in CRC by regulating miR-646 and miR-381-3p targeting of RAB11FIP2.MethodsWe identified the target microRNAs (miRNAs) of CASC11 and the target genes of miR-646 and miR-381-3p using bioinformatic methods. A dual-luciferase reporter assay was performed to validate the target relationship. Quantitative real-time PCR (qRT-PCR), western blotting (WB), and immunohistochemistry (IHC) were used to measure the RNA and protein expression levels. Rescue experiments in vitro and in vivo were performed to investigate the influence of the CASC11/miR-646 and miR-381-3p/RAB11FIP2 axis on CRC progression.ResultsWe found that CASC11 binds to miR-646 and miR-381-3p in the cytoplasm of CRC cells. Moreover, miR-646 and miR-381-3p inhibitors reversed the suppressive effect of CASC11 silencing on CRC growth and metastasis in vitro and in vivo. We further confirmed that RAB11FIP2 is a mutual target of miR-646 and miR-381-3p. The expression levels of CASC11 and RAB11FIP2 in CRC were positively correlated and reciprocally regulated. Further study showed that CASC11 played an important role in regulating PI3K/AKT pathway by miR-646 and miR-381-3p/RAB11FIP2 axis.ConclusionOur study showed that CASC11 promotes the progression of CRC as a ceRNA by sponging miR-646 and miR-381-3p. Thus, CASC11 is a potential biomarker and a therapeutic target of CRC.