bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Controlled Trial of DDS for Covid-19 ARDS
Authors: Lee Jong Hoon , Kanwar Badar , Lee Chul Joong , Balentine Jenny , Khattak Asif , Kast R. E. , Oh Sang-Suk , Sergi Consolato 
Published: June 2021

Abstract
Background Clinicians considered DDS administration to treat SARS-CoV-2 inflammasome. DDS is helpful in the molecular regulation of Nod-like receptor family pyrin domain-containing 3 (NLRP3).Objective To study the targeting of NLRP3 itself or up-/downstream factors of the NLRP3 inflammasome by DDS must be responsible for its observed preventive effects, functioning as a competitor.Methods This is a randomized controlled trial (RCT). We set out to use objective criteria of improvement. We treated the patients with standard Covid-19 acute respiratory distress syndrome (ARDS) treatment with DDS. The RCT results were analyzed.Results ARDS progression was blocked in 17 of 19 total patients at the first period. The 44 subjects were analyzed during the second period. It is significant at the ARDS onset stage. The mortality of ARDS-onset patients was 0% with DDS and 40% without DDS among the total of 65 cases. The t-value of RCT is -1.5, and the p-value is .075475. The result is significant at p < 0.10. ARDS onset with DDS prescribed group survived more 90% than ARDS onset without DDS group. The chi-square is 5.8108. The p-value is .015928. (Significant at p < .05) (RR 0.15, OR 0.09)Conclusion There was a significant difference in DDS treatment results in the ARDS-onset group. We confirmed that DDS clinically treated the onset of ARDS by targeting SARS-CoV-2-activated inflammasomes. Like chemically reacting substances, inflammasome and DDS compete, proving that it is effective in early ARDS.ClinicalTrials.gov Identifier: NCT04918914
Valorization of Restaurant Waste Oil Over Cow-bone Doped Siliceous Termite Hills Catalysts Towards Biodiesel Production
Authors: Olubunmi Babatunde Esther , Bamidele Saka H , Alade Aderibigbe F , Adeyinka Yusuff , Karmakar Bisheswar , Rokhum Lalthazuala , Halder Gopinath 
Published: June 2021

Abstract
Treated termite hill is a potent heterogeneous catalyst in the synthesis of biodiesel from restaurant waste oil (RWO). Two catalysts (raw cow-bone supported on silica; R-SC1.5 and calcined cow bone supported on silica; K-SC1.5) were developed and used in biodiesel production. The maximum conversion of RWO was 95.12 % using K-SC1.5 at reaction time 2.5 h, methanol to oil ratio 9:1, temperature 65°C and catalyst loading of 2 %w/w. The prepared catalysts were characterized using SEM, EDAX, FTIR, XRD and BET analysis. The kinetics of the RWO with R-SC1.5 and K-SC1.5 was further studied. The Ea and A were found to be 41.4 kJ mol− 1, 53.41 kJ mol− 1 and 2.24 ×104 min− 1, 2.29×106 min− 1 respectively. The transesterification reaction adhered to first order law, while physicochemical properties were within ASTM limits. Reusability of K-SC1.5 was also examined, which revealed effectiveness up to 5 reuses without significant reduction in biodiesel yield.
CTR9-Mediated JAK2/STAT3 Pathway Promotes The Proliferation, Migration and Invasion of Human Glioma Cells
Authors: Xu Yang , Chen Jiaguo , He Gao , Zhang Yuhai 
Published: June 2021

Abstract
Background

CTR9 (Cln three requiring 9) has been reported to be implicated in protein modification and oncogenesis of several human cancers. However, the protein expression and mechanism of CTR9 in glioma progression remain unclear.
Methods

We analyzed mRNA expression of CTR9 and CTR9-related survival curves in the public database. Then we detected CTR9 expression in glioma tissues and constructed U251 and U87 cells with stable silencing or overexpression of CTR9. Cell function tests and Western blot were conducted to explore the effects of CTR9 on glioma proliferation, invasion and migration, as well as the specific mechanism. All the date was presented as means ± SEM. Two-sample t-test and one-way analysis of variance (ANOVA) were used to identify whether there was a significant difference between each group of data.
Results

We found that CTR9 was overexpressed in glioma and inversely associated with glioma patient survival. The results manifested that knockdown of CTR9 suppressed the proliferation, migration and invasion of glioma cells, while overexpression facilitated them. The underlying molecular mechanism may involve the regulation of JAK2/STAT3 pathway by CTR9.
Conclusion

Our present study indicates that CTR9 is highly expressed in glioma and related to glioma grading and prognosis. CTR9 regulates malignant behaviors of glioma cells by activating JAK2/STAT3 pathway. Therefore, CTR9 is a promising biomarker for the diagnosis,targeted therapy and prognosis evaluation of glioma.
Impact of ERT and Follow up of 17 Patients from the Same Family with Mild form of MPS II
Authors: Stephan Bruno de Oliveira , Quaio Caio Robledo , Spolador Gustavo Marquezani , de Paula Ana Carolina , Curiati Marco Antônio , Martins Ana Maria , Leal Gabriela Nunes , Tenorio Artur , Finzi Simone , Chimelo Flavia Teixeira , Matas Carla Gentile , Honjo Rachel Sayuri , Bertola Debora Romeo , Kim Chong Ae 
Published: June 2021

Abstract
Background: Mucopolysaccharidosis type II, also known as Hunter syndrome, is a rare X-linked recessive disorder caused by deficiency of the lysosomal enzyme iduronate-2- sulfatase (IDS), leading to progressive accumulation of glycosaminoglycans (GAGs) in several organs. Over the years, Enzyme Replacement Therapy (ERT) has provided significant benefit for patients, retarding natural progression of the disease.Results: We evaluated 17 patients from the same family with a mild form of MPS type II; proband had developed acute decompensated heart failure refractory to clinical measurements at 23 years and needed a rather urgent heart transplant; however, he died from surgery complications shortly after the procedure. Nevertheless, subsequently to his tragic death, 16 affected male relatives were detected after biochemical tests identifying low or absent activity of IDS enzyme and confirmed by molecular analysis of IDS gene.Following diagnosis, different options of treatment were decided: 6 patients startedERT with Elaprase® (Idursulfase) soon after, while other 10 remained without ERT;eventually, 4 patients among the latter group began ERT with Hunterase® (Idursulfase Beta). None presented adverse effects to neither forms of the enzyme. Among the 6 individuals without any ERT, two died of natural causes, after reaching 70 years. Despite the variable phenotype within same family (mainly heart dysfunctions and carpal tunnel syndrome), all 14 remaining patients are alive with independent style of life.Conclusion: Here we report the variable progress of disease with and without ERT in a large Brazilian family with attenuated form of MPS II, harboring the same missense variant in the IDS gene.
Bone Mineral Density, Body Composition, Physical Activity Level, Muscle Strength and Smoking Status in Adults Men After Spinal Cord Injuries
Authors: Kopiczko Anna , Cieplińska Joanna 
Published: June 2021

Abstract
Background

In this cross-sectional study we aimed to investigate the association of physical activity level, muscle strength, body composition and smoking status with bone mineral density in adults men after spinal cord injuries.
Methods

The study covered 50 men after spinal cord injuries aged 35.6 ± 4.9 years (25 wheelchair rugby players and 25 without sports training). Bone mineral density was measured by densitometry. Body Mass Index and body fat percentage was calculated. Fat mass and fat-free mass were estimated from somatic. An interview method using the Global Adult Tobacco Survey. Muscle strength- maximal hand grip strength was measured using a Jamar dynamometer.
Results

The active men after SCI were significantly higher bone parameters BMD prox, BMC dis and prox, and T-score prox (large effect). Of all the variables analysed, the strongest relationships with bone parameters were consistently found for PA, FM, and age. The strength of bone status relationships with PA is mostly higher than that of the relationships with FM except BMD dis (F = 4.4 v. 12.4). The BMC parameter proved to be the most reliable (for both dis and prox) and the highest values of R^2 corr were found, ranging at 7–8% of the analysed set of traits exhausting the variance of this parameter. HGS and AS in years proved to be relevant only for BMD dis. Age when injury occurred (years) proved to be relevant only for T-score prox. Nonsmoking activity men after SCI had the most advantageous values of means BMD in forearm.
Conclusion

Despite its high injury rates, rugby can be considered a sport that has a beneficial effect on BMD. Physical activity level in the form of 5 and more years wheelchair rugby training has been shown to be the strongest factor affecting bone health. Active smoking especially in rugby players influenced lower averaged BMD values.
Microglial ApoD Induced NLRC4 Inflammasome Activation Promotes Alzheimer’s Disease Progression
Authors: Yu Yaliang , Lv Jianzhou , Ma Dan , Han Ya , Zhang Yaheng , Xu Pinli , Wang Shanlong , Wang Zhitao 
Published: June 2021

Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with no effective therapies. It’s well-known that chronic neuroinflammation plays a critical role in the onset and progression of AD. Proper neuronal-microglial interactions are essential for brain functions. However, as the main existence of immune cells, determining the role of microglia in Alzheimer’s neuroinflammation and the associated molecular basis has been challenging. Herein, the inflammatory factors in the sera of AD patients were detected and the association with microglia activation was analyzed. The mechanism regarding the microglial inflammation was investigated. The IL6 and TNF-α were found to be significantly increased in the AD stage. Further analysis revealed microglia were extensively activated in AD cerebra releasing mounts of cytokines to impair the neural stem cells (NSCs) function. Moreover, ApoD induced NLRC4 inflammasome was activated in microglia, which gave rise to the proinflammatory phenotype. Targeting the microglial ApoD promoted NSCs self-renewal and inhibited neuron apoptosis. These findings demonstrate the critical role of ApoD in microglial inflammasome activation, and for the first time reveal that microglia-induced inflammation suppresses neuronal proliferation. Our studies establish the cellular basis for microglia activation in AD progression, and shed lights on cellular interactions important for AD treatment.
The Influence of Physical Exercise on College Students' Ego Effect, Psychological Resilience and Negative Emotions: A Descriptive, Cross-Sectional Study
Authors: Li Jian , Li Mei-yue , Zhang Chong 
Published: June 2021

Abstract
Background

At present, college students mental health problem has drawn a wide attention. The aim of this study was to explore the influence of physical exercise on college students' ego effect, psychological resilience and negative emotions.
Methods

A cross-sectional study was conducted with a targeted sample of 1500 college students and above who were 1–3 undergraduate students. The participants were randomly selected. Data were collected using apaper-based questionnaire. One-way ANOVA and chi-square test were used for statistical analysis.
Result

college students' physical exercise can positively predict ego effect and psychological resilience (personal strength), and negatively predict negative emotions. College students' ego effect and psychological resilience (personal strength) can negatively predict their negative emotions. The mediating effects between physical exercise and negative emotions accounted for 26.78% and 31.7% of the total effects. Family support dimension plays a significant negative regulatory role between physical exercise and negative emotion, while the interaction between interpersonal assistance and physical exercise is not significant, which can not regulate the relationship between physical exercise and negative emotion.
Conclusion

Ego effect and psychological resilience (personal strength) play an important role in the process of improving negative emotions in college students' physical exercise, and family support dimension in psychological resilience (power of support). Negative regulation of the effect of physical exercise on negative emotions. It is further confirmed that ego effect and psychological resilience have intermediary effect and regulatory effect between physical exercise and negative emotion. It is recommended that college students: choose interesting, challenging and able to adhere to the completion of sports ,3 times a week should be high-intensity physical exercise. It is not only conducive to relieving bad emotions, improving interpersonal communication, improving ego effect and psychological resilience, but also can actively promote and maintain the physical health of college students.
BTN3A2 Expression Is Connected With Favorable Prognosis and High Infiltrating Immune in Lung Adenocarcinoma
Authors: Zhou Hao , Lin Yuansheng 
Published: June 2021

Abstract
Background: butyrophilin subfamily 3 member A2 (BTN3A2) as a important mediator in immune activation, its reported to be linked to many cancers progress. However, the relation with infiltrating immune and prognosis of BTN3A2 in Lung adenocarcinoma are not clear.Methods: In our study, we checked the mRNA expression and protein expression profile of BTN3A2 in Lung adenocarcinoma (LUAD) and its relation to clinical outcomes using TIMER, UALCAN database. Besides, we analyzed the survival of BTN3A2 in LUAD by Kaplan-Meier Plotter and PrognoScan database. Moreover, we analyzed Gene Set Enrichment Analysis (GSEA) of the BTN3A2. Next, we explored the relation of BTN3A2 expression with the immune infiltration by TIMER. At last, In order to enrich the regulatory mechanism of BTN3A2, we used miRarbase, starbase and miRDB dadabase to look for miRNAs targets of BTN3A2.Results: the mRNA along with protein expression of BTN3A2 in the LUAD group was lower in contrast with that in the normal group. Besides, high BTN3A2 expression was connected with good first progression (FP) and overall survival (OS) in LUAD. Then, the GSEA analysis demonstrated that T cell receptor signaling cascade, B cell receptor signaling cascade, natural killer cell mediated cytotoxicity, immune receptor activity, immunological synapse, T cell activation were enriched differentially in BTN3A2 high expression phenotype of LUAD. Moreover, BTN3A2 expression is remarkable positively correlation with invading levels of tumor purity, B cells, neutrophil, CD4+ T cells, dendritic cells, macrophages, and CD8+ T cells in LUAD, and B cells and dendritic cells were linked with good prognosis of LUAD. To further enrich the possible regulatory mechanisms of BTN3A2, we analyzed the miRNA targets. The results showed that hsa-miR-17-5p may be miRNA targets of BTN3A2.Conclusion: Taking together, we provide evidence of BTN3A2 as possible prognosis biomarkers of LUAD. Besides, high BTN3A2 expression in LUAD may influence prognosis because of immune invasion. Moreover, our findings provide a potential mechanism that hsa-miR-17-5p may be miRNA targets of BTN3A2.
Wetlands of the South American Pacific Coast: A Bibliometric Approach
Authors: RIVERA Gabriel , GONZALES Sergio , Aponte Héctor 
Published: June 2021

Abstract
Wetlands are ecosystems susceptible to anthropogenic impacts; analysis of the scientific publications on these ecosystems can be used as a reference for the adopting of measures to facilitate research and conservation. This bibliometric analysis aimed to evaluate the temporal evolution of scientific publications and trends in research topics related to the wetlands of Ecuador, Peru, and Chile; this region includes an extended desertic region in the southern Pacific. A total of 411 articles published during the period from 2000 to 2019 were reviewed. The most frequent subject areas were 'birds' and 'other types of fauna' (20.7% and 19.2%, respectively); the diversity of publications was similar, but the proportions of the total subject areas for each country varied. The number of papers published per year was found to be increasing. The thematic areas related to these ecosystems that require strengthening in Ecuador, Peru and Chile are identified (e. g. 'hydrology and sediment' in Peru, 'microscopic organisms' in Chile, and 'birds' in Ecuador). Decision-makers should use this information to promote the development of the lines of research identified for each country.
Dynamic Evolution Law of Roof Deformation in Continuous Mining and Continuous Backfilling Method
Authors: Xu Bin , Yang Renshu , Li Yongliang , Lu Bin 
Published: June 2021

Abstract
To investigate the dynamic evolution law of roof deformation in the continuous mining and continuous backfilling (CMCB) method, the alternating bearing characteristics of coal and the backfilling body were obtained through statistical analysis. On the basis of two-step mining and the elastic foundation beam theory, the mechanical model of the entire stage roof deformation was established, and the dynamic change law of roof settlement was obtained. On the basis of the working face of CMCB in Haoyuan Coal Mine, the deformation rule of the two-step mining roof was analyzed. In the first stage of mining, the coal pillar is the main bearing structure, the deformation of the roof is small, and the distribution is wavy. In the second stage, the backfilling body gradually becomes the main bearing structure, and the deformation of the roof significantly increases and exhibits a U-shaped distribution. The results obtained by numerical simulations reveal that four-step mining increases the width of the coal pillars and the roof deformation is effectively controlled during the filling process. After the filling is completed, the roof remains stable under the support of the filling body under different filling modes; therefore, its final settlement remains consistent. Through field measurement, it was found that the CMCB method can effectively control the roof subsidence in Haoyuan Coal Mine.
The Stability, Structural, Electronic, and Optical Properties of Hydrogenated Silicene Under Hydrostatic Pressures: A First-principle Study
Authors: Kumar V , Santosh R 
Published: June 2021

Abstract
The structural, electronic, and optical properties of hydrogenated silicene have been studied under different hydrostatic pressures using first-principle calculations. The binding energy and band structure have been calculated for Chair (C-) and Boat (B-) structures, which are having good stability at 0 GPa, 3 GPa, 6 GPa, 9 GPa, 12 GPa, 15 GPa, and 18 GPa hydrostatic pressures. Stability has been verified using binding energy and phonon calculations. The C- and B- structures have become metallic and unstable at 21 GPa. The optical properties of B-configuration have been studied in the energy range of 0-20 eV. Five optical parameters such as conductivity threshold (σth), dielectric constant ε(0), refractive index n(0), birefringence Δn(0) and plasmon energy (ħωp) have been calculated for the first time under different hydrostatic pressures. The calculated values are in good agreement with the reported values at 0 GPa.
Point-Of-Care Testing in Paediatric Settings in the UK and Ireland: a Cross-Sectional Study
Authors: Pandey Meenu , Lyttle Mark D , Cathie Katrina , Munro Alasdair , Waterfield Thomas , Roland Damian 
Published: June 2021

Abstract
Background: Point-of-care testing (POCT) is diagnostic testing performed at or near to the site of the patient. Understanding the current capacity, and scope, of POCT in this setting is essential in order to respond to new research evidence which may lead to wide implementation.Methods: A cross-sectional online survey study of POCT use was conducted between 6th January and 2nd February 2020 on behalf of two United Kingdom (UK) and Ireland-based paediatric research networks (Paediatric Emergency Research UK and Ireland, and General and Adolescent Paediatric Research UK and Ireland). Results: In total 91/109 (83.5%) sites responded, with some respondents providing details for multiple units on their site based on network membership (139 units in total). The most commonly performed POCT were blood sugar (137/139; 98.6%), urinalysis (134/139; 96.4%) and blood gas analysis (132/139; 95%). The use of POCT for Influenza/Respiratory Syncytial Virus (RSV) (45/139; 32.4%, 41/139; 29.5%), C-Reactive Protein (CRP) (13/139; 9.4%), Procalcitonin (PCT) (2/139; 1.4%) and Group A Streptococcus (5/139; 3.6%) and was relatively low. Obstacles to the introduction of new POCT included resources and infrastructure to support test performance and quality assurance.Conclusion: This survey demonstrates significant consensus in POCT practice in the UK and Ireland but highlights specific inequity in newer biomarkers, some which do not have support from national guidance. A clear strategy to overcome the key obstacles of funding, evidence base, and standardising variation will be essential if there is a drive toward increasing implementation of POCT.
Clinical Impact of Hemorrhagic Lesion Progression Following Moderate-to-Severe Traumatic Brain Injury: An Observational Cohort Study
Authors: Fletcher-Sandersjöö Alexander , Tatter Charles , Tjerkaski Jonathan , Bartek Jiri , Maegele Marc , Nelson David W , Svensson Mikael , Thelin Eric Peter , Bellander Bo-Michael 
Published: June 2021

Abstract
Background

Hemorrhage progression following traumatic brain injury (TBI) is not fully understood, and preventing it would be a potential therapeutic opportunity in TBI management. The aim of this study was to determine how non-operated hemorrhagic lesions progress following TBI, and how this affects outcome.
Methods

This was a retrospective observational cohort study of adult patients (≥ 15 years) with moderate-to-severe TBI. Hemorrhage volumes were calculated from computed tomography (CT) scans using semi-automated volumetric segmentation.
Results

In total, 643 patients were included, with a median Glasgow Coma Scale of 7. Contusions were the most common form of traumatic intracranial hemorrhage. The mean total lesion volume on the first CT scan was 4.29 ml, and the mean lesion progression volume (LPV), i.e. the increase in volume from first CT scan until the lesion had stopped progressing, was 3.85 ml. Contusions showed a significantly larger LPV than SDH and EDH (p < 0.001). The median lesion progression time (LPT), i.e. the time from injury until all lesions had stopped progressing, was 5.98 hours, with contusions progressing for a longer time than tSAH, SDH and EDH (p < 0.001). Hemorrhage progression also slowed exponentially over time, with almost no further expansion occurring 24 hours after trauma. In multivariable regression analysis, LPV was independently associated with 12-month Glasgow Outcome Score after adjusting for known TBI outcome predictors (p < 0.001).
Conclusions

Contusions were the most common form of traumatic intracranial hemorrhage, and exhibited both a larger LPV and longer LPT than extra-axial hematomas. Regression analysis indicated that LPV was independently related to, and possibly a driver of, unfavorable outcome. Interventions to prevent lesion progression are therefore likely to improve outcome in TBI patients. Moreover, this study suggests a wider window of opportunity to prevent lesion progression than what has previously been suggested.