bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Immune-Clinical Prognostic Index (ICPI) for Patients With De Novo Follicular Lymphoma Treated With R-CHOP/CHOP Chemotherapy
Authors: Lu Yaxiao , Yu Jingwei , Gong Wenchen , Su Liping , Sun Xiuhua , Bai Ou , Zhou Hui , Guan Xue , Zhang Tingting , Li Lanfang , Qiu Lihua , Qian Zhengzi , Zhou Shiyong , Meng Bin , Ren Xiubao , Wang Xianhuo , Zhang Huilai 
Published: July 2021

PurposeAlthough the role of tumor-infiltrating T cells in follicular lymphoma (FL) has been reported previously, the prognostic value of peripheral blood T lymphocyte subsets has not been systematically assessed. Thus, we aim to incorporate T-cell subsets with clinical features to develop a predictive model of clinical outcome.MethodsWe retrospectively screened a total of 1,008 patients, including 252 newly diagnosed de novo FL patients with available peripheral blood T lymphocyte subsets who were randomized to different sets (177 in the training set and 75 in the internal validation set). A nomogram and a novel immune-clinical prognostic index (ICPI) were established according to multivariate Cox regression analysis for progression-free survival (PFS). The concordance index (C-index), Akaike’s information criterion (AIC), and likelihood ratio chi-square were employed to compare the ICPI’s discriminatory capability and homogeneity to that of FLIPI, FLIPI2, and PRIMA-PI. Additional external validation was performed using a dataset (n = 157) from other four centers.ResultsIn the training set, multivariate analysis identified five independent prognostic factors (Stage III/IV disease, elevated lactate dehydrogenase (LDH), Hb &lt;120g/L, CD4+ &lt;30.7% and CD8+ &gt;36.6%) for PFS. A novel ICPI was established according to the number of risk factors and stratify patients into 3 risk groups: high, intermediate, and low-risk with 4-5, 2-3, 0-1 risk factors respectively. The hazard ratios for patients in the high and intermediate-risk groups than those in the low-risk were 27.640 and 2.758. The ICPI could stratify patients into different risk groups both in the training set (P &lt; 0.0001), internal validation set (P = 0.0039) and external validation set (P = 0.04). Moreover, in patients treated with RCHOP-like therapy, the ICPI was also predictive (P &lt; 0.0001). In comparison to FLIPI, FLIPI2, and PRIMA-PI (C-index, 0.613-0.647), the ICPI offered adequate discrimination capability with C-index values of 0.679. Additionally, it exhibits good performance based on the lowest AIC and highest likelihood ratio chi-square score.ConclusionsThe ICPI is a novel predictive model with improved prognostic performance for patients with de novo FL treated with R-CHOP/CHOP chemotherapy. It is capable to be used in routine practice and guides individualized precision therapy.
Mixed Method Research on Football Coaches’ Competitive Behavior
Authors: Rodrigues José , Rodrigues Filipe , Resende Rui , Espada Mário , Santos Fernando 
Published: July 2021

ObjectiveThe purpose of this study was to present the reliability of three validated measures, namely the System of Analysis of Instruction in Competition, the Questionnaire on Coach Instructional Behavior Expectations, and the Questionnaire on Coach Instructional Behavior Perception that could be used in a mix-method approach.MethodsThree instruments underwent a robust process of construct and reliability analysis. Inter− and intra-observer reliability was tested for the observational instrument using Cohen’s k-agreement measure. Reliability values above 0.85 were considered as a good agreement between and within observers. To verify the internal consistency of the questionnaires, the correlation coefficients were considered.ResultsThe results related to intra-observer and inter-observer reliability showed that intra-observer reliability k-agreement values ranged between 0.912 and 1 for observer 1, and 0.82 and 1 for observer 2. For inter-observer reliability, k-agreement values ranged between 0.885 and 1 between observers. Thus, values for reliability are above acceptable. The correlation coefficient values recorded for the questionnaires on instruction expectations in the competitive moment were above 0.82 and significant (p &lt; 0.05), and for the questionnaire on instruction perception in competition above 0.88 and significant (p &lt; 0.05). The pilot study showed some divergent results across expectations, behavior during competition, and perception about the instruction behavior.ConclusionThe observational system and the expectations and perceptions questionnaires, used in a complementary way, can be considered as a mix-method approach for studies aiming to examine coaches’ competitive behavior.
Development and Implementation of Couple-Based Collaborative Management Model of Type 2 Diabetes Mellitus for Community-Dwelling Chinese Older Adults: A Pilot Randomized Trial
Authors: Liu Yuyang , Xiao Xiaocun , Peng Chaonan , Zhao Tianyi , Wu Yanjuan , Yu Wanwen , Ou Liping , Chen Xiongfei , Wu Xueji , Xu Dong Roman , Liao Jing 
Published: July 2021

Background: To mobilize family's positive involvement in improving and sustaining self-management activities of older adults with diabetes, we developed a couple-based collaborative management model (CCMM) for community-dwelling older Chinese.Methods: The model was developed stepwise through applying theoretical models, interviewing older couples and community healthcare workers, as well as incorporating expert reviews. A 3-month pilot study was conducted to test the model's feasibility and its treatment effects by linear regression on 18 pairs of older couples aged 60 years+, who were equally divided into a couple-based intervention arm and a patient-only control arm.Results: The developed CCMM covered four theory-driven intervention modules: dyadic assessment, dyadic education, dyadic behavior-change training, and dyadic monitoring. Each module was delivered by community healthcare workers and targeted at older couples as the management units. Based on interviews with older couples and healthcare workers, 4 weekly education and training group sessions and 2-month weekly behavior change booster calls were designed to address older adults' main management barriers. These modules and session contents were evaluated as essential and relevant by the expert panel. Furthermore, the CCMM showed good feasibility and acceptability in the pilot, with non-significant yet more positive changes in physiological outcomes of diabetic participants and couples' well-being and exercise levels of these in the intervention arm than their controlled counterparts.Conclusion: We systematically developed a couple-based collaborative management model of diabetes, which was well-received by healthcare practitioners and highly feasible among older Chinese couples living in the community. The model's treatment effects need to be verified in fully powered randomized controlled trials.Clinical Trial Registration:http://www.chictr.org.cn/showproj.aspx?proj=42964, identifier: ChiCTR1900027137.
Vaccine Composition Formulated with a Novel Lactobacillus-Derived Exopolysaccharides Adjuvant Provided High Protection against Staphylococcus aureus
Authors: Zhang Haochi , Pan Na , Ma Cheng , Liu Bohui , Xiu Lei , Tong He , Sheng Shouxin , Liang Yanchen , Li Haotian , Ma Fangfei , Bao Xuemei , Hu Wei , Wang Xiao 
Published: July 2021

A vaccine that effectively targets methicillin-resistant Staphylococcus aureus (MRSA) is urgently needed, and has been the focus of studies by numerous research groups, but with limited success to date. Recently, our team found that exopolysaccharides derived from probiotic Lactobacilluscasei strain WXD030 as an adjuvant-formulated OVA could upregulate IFN-γ and IL-17 expression in CD4+ T cells. In this study, we developed a vaccine (termed rMntC-EPS) composed of S. aureus antigen MntC and Lactobacillus casei exopolysaccharides, which conferred high levels of protection against S. aureus infection. Methods: Six–eight-week-old female mice were vaccinated with purified rMntC-EPS30. The immune protection function of rMntC-EPS30 was assessed by the protective effect of rMntC-EPS30 to S. aureus-induced pulmonary and cutaneous infection in mice, bacterial loads and H&E in injury site, and ELISA for inflammation-related cytokines. The protective mechanism of rMntC-EPS30 was assessed by ELISA for IgG in serum, cytokines in the spleen and lungs of vaccinated mice. In addition, flow cytometry was used for analyzing cellular immune response induced by rMntC-EPS30. For confirmation of our findings, three kinds of mice were used in this study: IL-17A knockout mice, IFN-γ knockout mice and TCRγ/δ knockout mice. Results: rMntC-EPS30 conferred up to 90% protection against S. aureus pulmonary infection and significantly reduced the abscess size in the S. aureus cutaneous model, with clearance of the pathogen. The rMntC-EPS vaccine could induce superior humoral immunity as well as significantly increase IL-17A and IFN-γ production. In addition, we found that rMntC-EPS vaccination induced robust Th 17/γδ T 17 primary and recall responses. Interestingly, this protective effect was distinctly reduced in the IL-17A knockout mice but not in IFN-γ knockout mice. Moreover, in TCRγ/δ knockout mice, rMntC-EPS vaccination neither increased IL-17A secretion nor provided effective protection against S. aureus infection. Conclusions: These data demonstrated that the rMntC formulated with a novel Lactobacillus-derived Exopolysaccharides adjuvant provided high protection against Staphylococcus aureus. The rMntC-EPS vaccine induced γδ T cells and IL-17A might play substantial roles in anti-S. aureus immunity. Our findings provided direct evidence that rMntC-EPS vaccine is a promising candidate for future clinical application against S. aureus-induced pulmonary and cutaneous infection.
Planificación en la gestión de seguridad industrial e higiene ocupacional
Authors: Jiménez Boreidy 
Published: July 2021

La investigación tuvo como objetivo describir el proceso de planificación en la gestión de seguridad industrial e higiene ocupacional en la industria petrolera venezolana. La metodología fue de tipo descriptiva, bajo un diseño de campo no experimental, y transeccional. La población estuvo conformada por las gerencias de Servicio Lacustre de la división occidente. Para la recolección de datos se utilizó la encuesta mediante un cuestionario, el mismo quedó conformado por 9 ítems con escala dicotómica. La validez se realizó a través del juicio de expertos, y su confiabilidad por el método de Küder – Richardson, donde se obtuvo 0,85. El análisis de los datos se realizó mediante la estadística descriptiva, a través del estudio de las frecuencias relativas. Se concluyó que estas gerencias poseen moderada presencia de las políticas, objetivos, leyes y normas inmersos en el proceso de planificación en la gestión de seguridad industrial e higiene ocupacional
Efectos medio ambientales ocasionados por la explotación de estaño
Authors: Avendaño Osinaga Ramiro Abel 
Published: July 2021

El objetivo de este estudio fue identificar los efectos ambientales provocados por la explotación de yacimientos estanníferos en la localidad de Huanuni, Bolivia. La metodología empleada requirió del análisis del impacto ambiental tomando en cuenta dos aspectos: primero, la magnitud del impacto sobre sectores específicos del medio ambiente; segundo, la importancia de las acciones propuestas sobre las características y condiciones ambientales específicas.
Los resultados demuestran que las actividades de extracción de estaño son rentables, pero a la vez provocan: contaminación del agua; generación de gases, sales, partículas y contaminación acústica. En algunos casos estos efectos pueden cobrar vidas humanas. Se concluyó que la implementación de políticas ambientales no afectaría significativamente en la rentabilidad y permitiría gozar la beneficios directos e indirectos para los pobladores.
Frailty, Age, and Postdialysis Recovery Time in a Population New to Hemodialysis
Authors: Fitzpatrick Jessica , Sozio Stephen M. , Jaar Bernard G. , Estrella Michelle M. , Segev Dorry L. , Shafi Tariq , Monroy-Trujillo Jose M. , Parekh Rulan S. , McAdams-DeMarco Mara A. 
Published: July 2021

Background
Frailty, a phenotype characterized by decreased physiologic reserve and the inability to recover following confrontation with a stressor like hemodialysis, may help identify which patients on incident hemodialysis will experience longer postdialysis recovery times. Recovery time is associated with downstream outcomes, including quality of life and mortality. We characterized postdialysis recovery times among patients new to hemodialysis and quantified the association between frailty and hemodialysis recovery time.

Methods
Among 285 patients on hemodialysis enrolled in the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study, frailty was measured using the Fried phenotype. Self-reported recovery time was obtained by telephone interview. We estimated the association of frailty (intermediately frail and frail versus nonfrail) and postdialysis recovery time using adjusted negative binomial regression.

Results
Median time between dialysis initiation and study enrollment was 3.4 months (IQR, 2.7–4.9), and that between initiation and recovery time assessment was 11 months (IQR, 9.3–15). Mean age was 55 years, 24% were >65 years, and 73% were Black; 72% of individuals recovered in ≤1 hour, 20% recovered in 1–6 hours, 5% required 6–12 hours to recover, and <5% required >12 hours to recover. Those with intermediate frailty, frailty, and age ≤65 years had 2.56-fold (95% CI, 1.45 to 4.52), 1.72-fold (95% CI, 1.03 to 2.89), and 2.35-fold (95% CI, 1.44 to 3.85) risks, respectively, of longer recovery time independent of demographic characteristics, comorbidity, and dialysis-related factors.

Conclusions
In adults new to hemodialysis, frailty was independently associated with prolonged postdialysis recovery. Future studies should assess the effect of frailty-targeted interventions on recovery time to improve clinical outcomes.
Post-Discharge Mortality and Rehospitalization among Participants in a Comprehensive Acute Kidney Injury Rehabilitation Program
Authors: Singh Gurmukteshwar , Hu Yirui , Jacobs Steven , Brown Jason , George Jason , Bermudez Maria , Ho Kevin , Green Jamie A. , Kirchner H. Lester , Chang Alex R. 
Published: July 2021

Key Points

Using innovative, patient-centered interventions, 68% of eligible high-risk patients with AKI were enrolled and all came to nephrology follow-up.Participation was associated with improvement in 30-day postdischarge rehospitalization and mortality, with similar 90-day trends.The interventions present a roadmap for improving enrollment in AKI randomized controlled trials and should be tested further.

Background
Hospitalization-associated AKI is common and is associated with markedly increased mortality and morbidity. This prospective cohort study examined the feasibility and association of an AKI rehabilitation program with postdischarge outcomes.

Methods
Adult patients hospitalized from September 1, 2019 to February 29, 2020 in a large health system in Pennsylvania with stage 2–3 AKI who were alive and not on dialysis or hospice at discharge were evaluated for enrollment. The intervention included patient education, case manager services, and expedited nephrology appointments starting within 1–3 weeks of discharge. We examined the association between AKI rehabilitation program participation and risks of rehospitalization or mortality in logistic regression analyses adjusting for comorbidities, discharge disposition, and sociodemographic and kidney parameters. Sensitivity analysis was performed using propensity score matching.

Results
Among the high-risk patients with AKI who were evaluated, 77 of 183 were suitable for inclusion. Out of these, 52 (68%) patients were enrolled and compared with 400 contemporary, nonparticipant survivors of stage 2/3 AKI. Crude postdischarge rates of rehospitalization or death were lower for participants versus nonparticipants at 30 days (15% versus 34%; P=0.01) and at 90 days (31% versus 51%; P=0.01). After multivariable adjustment, participation in the AKI rehabilitation program was associated with lower risk of rehospitalization or mortality at 30 days (OR, 0.41; 95% CI, 0.16 to 0.93), with similar findings at 90 days (OR, 0.52; 95% CI, 0.25 to 1.05). Due to small sample size, propensity-matched analyses were limited. The participants’ rehospitalization or mortality was numerically lower but not statistically significant at 30 days (18% versus 31%; P=0.22) or at 90 days (47% versus 58%; P=0.4).

Conclusions
The AKI rehabilitation program was feasible and potentially associated with improved 30-day rehospitalization or mortality. Our interventions present a roadmap to improve enrollment in future randomized trials.
METHOD FOR DETECTING THE COORDINATES OF SUBSCRIBERS IN THE ABSENCE OF COMMUNICATION INFRASTRUCTURE OF NETWORK OPERATORS USING A FLYING NETWORK BASED ON A GROUP OF UAVs
Authors: Динь Ч.З. , Киричек Р.В. 
Published: July 2021

Представлен протокол CMMpP, разработанный на основе модификации протоколов IEEE 802.11p и IEEE 1609.4, для поддержания связи между узлами в летающей сети, осуществления связи между беспилотными летательными аппаратами (БПЛА) и элементами группы БПЛА. Предложен метод позиционирования на основе групп БПЛА в быстро разворачиваемых летающих сетях для экстренных служб путем обнаружения сигналов Wi-Fi, отправленных со смартфонов пострадавших
It is presented the CMMpP protocol, developed on the basis of a modification of the IEEE 802.11p and IEEE 1609.4 protocols, to maintain a connection between nodes in a flying network and to communicate between unmanned aerial vehicles (UAVs) and UAV group elements. It is proposed a method for detecting the coordinates of subscribers based on groups of UAVs in quickly deployed flying networks for emergency services by detecting Wi-Fi signals that are sent from the smartphones of injured people.
ELECTROMAGNETIC SECURITY OF MODERN WIRELESS TECHNOLOGIES: ICNIRP DOCUMENTS
Authors: Сподобаев Ю.М. 
Published: July 2021

Представлена информация о существенно обновленных в этом году рекомендациях ICNIRP, которые служат ориентиром для многих стран в деле защиты человека от электромагнитных полей. Новый документ разработан по результатам обобщений многолетних зарубежных исследований при реализации концепции контроля и оценки поглощенной объектом электромагнитной энергии. Рассмотрены положения документа, представляющие интерес для технических специалистов с научно-технической и методической точек зрения. Показано, что электродинамическая обоснованность, установленные границы, временные параметры и степень воздействий соответствуют основным физическим представлениям. Отмечено, что достижения отечественной биофизики электромагнитных воздействий должны гармонично войти в национальные обоснования медико-биологических, научно-технических и нормативно-правовых решений.
The ICNIRP recommendations, which provide guidelines for many countries in protecting people from electromagnetic fields, have been substantially updated this year. The new document was developed on the basis ofthe results of the consolidation of multi-year studies with the consistent implementation of the concept of monitoring and evaluation of electromagnetic energy absorbed by an object. Some provisions of the document, which are of interest to technical specialists from scientific, technical and methodological points of view, areconsidered. It is shown that electrodynamic validity, established boundaries, time parameters and the degree of impact correspond to the basic physical concepts.
POSSIBILITIES OF EXPANDING THE COVERAGE AREA OF LOCAL FUNCTIONAL ADDITIONS WHILE PROVIDING HIGH-PRECISION CORRECTIONS OF SATELLITE RADIO NAVIGATION SYSTEM ERRORS
Authors: Вовасов В.Е. 
Published: July 2021

Анализируются методы высокоточной коррекции погрешностей спутниковой радионавигационной системы (СРНС). Предлагается рассмотреть усовершенствованную версию, основанную на определении дифференциальных поправок (ДП) сети децентрализованных станций, обеспечивающих расширение зоны действия локальных функциональных дополнений. С этой целью вычисляются поправки в реальном масштабе времени, практически лишенные ионосферной и тропосферной составляющих. Такой метод позволяет устранить некоторые флуктационные составляющие оценок псевдо- дальностей (ПД) и, таким образом, значительно (до нескольких тысяч километров) увеличить зону аппроксимации, обеспечив высокую точность поправок.
The methods of high-precision error correction of the satellite radio navigation system are analyzed. It is proposed to consider an improved version of correction based on the definition of differential corrections of a chain of decentralized stations. For this purpose, realtime corrections, practically deprived of ionospheric and tropospheric components, are calculated.
THERMAL STABILITY OF THE BAND-STOP FILTER OF THE TRANSMITTING FEEDER PATH OF INCREASED POWER
Authors: Алексейчик Л.В. , Андриевский Н.В. , Кизима А.Г. , Павлов Н.В. 
Published: July 2021

Предложены варианты повышения стабильности температурного режима режекторного фильтра радиоастрономического диапазона для бортового информационно-навигационного комплекса космического аппарата ГЛОНАСС с целью обеспечения минимального перепада температур между керамическими диэлектрическими резонаторами и их посадочными местами (за счет улучшения кондуктивного теплоотвода). Рассмотрены два варианта выполнения диэлектрических подставок керамического диэлектрического резонатора: в виде усеченного конуса, выполненного из кварцевого стекла, и цилиндрической подставки из горячепрессованного нитрида бора с параллельным прессованием слоев.
Options are proposed for increasing the temperature stability of the band-stop filter of the radio astronomy range for radio navigation complex GLONASS in order to ensure a minimum temperature difference between ceramic dielectric resonators and their seats due to improved conductive heat removal. Two versions of the dielectric support of ceramic dielectric resonator are proposed: in the form of a truncated cone made of quartz glass and cylindrical support made of hotpressed boron nitride with a parallel pressing of layers.
What’s in organic wine consumer mind? A review on purchasing drivers of organic wines
Authors: Maesano Giulia , Di Vita Giuseppe , Chinnici Gaetano , Gioacchino Pappalardo , D'Amico Mario 
Published: July 2021

Consumer interest in organic wine is growing, but the effects of organic label, consumer quality perception and the support for the benefits claim of organic wine are not yet fully understood and at times doubtful. The literature shows a very heterogeneous picture regarding consumer behaviour and preferences for organic wine. This study seeks to understand the link between organic wine and consumer’ purchasing drivers. Using a systematic literature review, the paper explores the characteristics of consumer of organic wine, the motivation on consumer behaviour and preferences for organic wine, as well as the sensory quality and the presence of additives when evaluating wine quality and in shaping consumers’ attitudes. The results show how socio-economic and psychological characteristics of consumer as well as quality perception affect their behaviour for organic wine. Little consensus on the benefits in terms of improved sensory quality of organic wine compared to conventional one. Among sensory qualities, taste has been found to be both a key driver and barrier to organic wine consumption. Based on literature studies, consumers have positive opinions toward organic wine, which is perceived as healthy and environmental friendly. However, despite the growing market interest in wine, scientific information about the organoleptic differences between conventional and organic remains scarce and the topic requires more in-depth analysis. Understanding the profile of consumer and the factors that influence consumer’ behaviour provide information to the organic wine industry.