bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol Consumption by Women in the Previous Year Who Were Unaware They Were Pregnant
Authors: de Moura Adaene Alves Machado , Kaur-Aujla Harjinder , Gonçalves Angelica Martins de Souza , Júnior Fernando José Guedes da Silva , Perruci Ludmila Gonçalves , Zerbetto Sonia Regina , Fernandes Marcia Astrês , Zafar Shazia , Santos Manoel Antônio dos , Wagstaff Christopher , Pillon Sandra 
Published: September 2021

Abstract
Objective: To evaluate the socio-cultural factors associated with alcohol consumption by women, in the previous year, and during the gestational period (not knowing that they were pregnant).Method: This is a cross-sectional study, conducted with 112 pregnant women using Primary Health Care services in two municipalities in São Paulo state, Brazil. Sociodemographic and obstetric information tests to identify problems associated with alcohol were used.Results: The majority of participants were young, married, were of the Evangelical faith, had a low level of education and family income, did not work and lived in their own homes. The prevalence of alcohol use in the year before pregnancy was 57.1%, 6.8% drank in a binge pattern, of which 32.1% did not know they were pregnant.Conclusion: Pregnant women and women of reproductive age, who are in risk groups and have a high vulnerability, should take priority for interventions related to substance use, especially alcohol.
Associations Between Serum Total Cholesterol Level and Bone Mineral Density in Older Adults
Authors: Hu Sheng , Zhang Wenxiong , Wang Silin , Zhang Deyuan , Zhang Yang , Ye Jiayue , Guo Qiang , Su Lang , Yu Dongliang , Peng Jinhua , Wei Yiping , Xu Jianjun 
Published: September 2021

Abstract
Background: Osteoporosis is a major clinical problem in elderly people. The correlation between total cholesterol and bone mineral density remains controversial.Methods: We obtained records from the National Health and Nutrition Examination Survey (NHANES) database for 4236 people aged over 60 without a diagnosis of cancer. We analyzed the relationship between total cholesterol and lumbar bone mineral density, using the statistical packages R and Empower Stats. We described the research population and performed stratified and single factor analysis, multiple equation regression analysis, smooth curve fitting, and threshold effect and saturation effect analysis.Results: A significant negative association was found between serum cholesterol levels and bone mineral density of the lumbar spine in the study population. Older adults ≥70 years of age had an inflection point at 280 mg / dl, and those with moderate physical activity had an inflection point at 203 mg / dl. The smooth curves fitted were all U-shaped.Conclusions: There is a negative association between total cholesterol and lumbar spine bone mineral density in people without cancer aged 60 or older.
Cytomegalovirus Reactivation in Immunocompetent Mechanical Ventilation Patients: A Prospective Observational Study
Authors: Zhang Zhihui , Liu Xuesong , Sang Ling , Chen Sibei , Wu Zhan , Zhang Jierong , Sun Yining , Huang Yongbo , Xu Yonghao , He Weiqun , Li Yimin , Liu Xiaoqing 
Published: September 2021

Abstract
Background: Cytomegalovirus (CMV) reactivation is associated with adverse prognoses of critically ill patients. However, the epidemiology and predictors of CMV reactivation in immunocompetent patients receiving mechanical ventilation (MV) are not clear. The aim of this study was to investigate the epidemiology and predictors of CMV reactivation in immunocompetent patients requiring MV.Methods: A single-center, prospective observational study (conducted from June 30, 2017 to July 01, 2018) with a follow-up of 90 days (September 29, 2018) that included 71 CMV-seropositive immunocompetent patients with MV at a 37-bed university hospital general intensive care unit (ICU) in China. Routine detection of CMV DNAemia was performed once a week for 28 days (Days 1, 7, 14, 21, and 28). CMV serology, laboratory findings, and clinical data were obtained during hospitalization.Results: Among 71 patients, 13 (18.3%) showed CMV reactivation within 28 days in the ICU. The median time to reactivation was 7 days. CMV reactivation was related to various factors, including body mass index (BMI), sepsis, N-terminal pro-b-type natriuretic peptide (NT-proBNP), blood urea nitrogen (BUN), and hemoglobin (Hb) levels (P < 0.05). In the multivariate regression model, BMI, Hb level, and sepsis were independently associated with CMV reactivation patients (P < 0.05). Moreover, the area under the receiver operating characteristic (AUROC) of BMI, Hb, and BMI combined with Hb was 0.69, 0.70, and 0.76, respectively. The duration of MV, hospitalization expense, length of ICU stay, and 90-day all-cause mortality rate in patients with CMV reactivation was significantly higher than in those without CMV reactivation (P < 0.05).Conclusions: Among immunocompetent patients with MV, the incidence of CMV reactivation was 18.3%. CMV reactivation was associated with several adverse prognoses. BMI, Hb, and sepsis were independent risk factors for CMV reactivation. BMI and Hb may predict CMV reactivation.
Comparative Evaluation of Shear Bond Strength of Composite to Dentin in Presence of Calcium Releasing Liners: An In-Vitro Study
Authors: Tohidkhah Saba , Ahmadi Elham , Abbasi Mahdi , Farimani Reza Morvaridi , Omrani Ladan Ranjbar 
Published: September 2021

Abstract
Background: The aim of current study was to evaluate and compare the influence of Dycal, Lime-lite, Theracal LC, Biodentine, Resin-modified glass ionomer cement (RMGIC), and Activa Bioactive as the pulp capping material on the shear bond strength of resin composite to dentin.Methods: A total of 70 extracted caries-free molars were randomly assigned to seven groups. Six test groups were covered with various protective liners: Dycal (GD), Theracal LC (GT), lime-lite (GL), Activa Bioactive (GA), Biodentine (GB), RMGIC (GR). The control group (GC)received no liner pretreatment. Each sample was bonded to resin composite using the total-etch tetric N bond adhesive. The samples were then tested for shear bond strength using the universal testing machine at a cross-head speed of 1 mm/min until bond failure occurred. The data were analyzed using the one-way ANOVA test followed by the Tamhane post-hoc test for pairwise comparisons of the groupsResults: Independent of the type of the applied liner, all groups exhibited inferior SBS to dentine compared to the control group. GT and GR showed significantly higher shear bond strength than GB and GD, which showed the lowest shear bond strength. GL and GA also had significantly lower SBS results than GT. The mode of fracture was predominantly cohesive in GD, GB, and GT and adhesive in GA.Conclusion: This present study concludes that the bond strength of resin-composite to dentine can be affected differently using various types of liners.
Relationship Between Perceived Organizational Support And Professional Values of Nurses: Mediating Effect of Emotional Labor
Authors: Peng Chaohua , Chen Ye , Zeng Tieying , Wu Meiliyang , Yuan Mengmei , Zhang Ke 
Published: September 2021

Abstract
Objectives: Perceived organizational support was a benefit for the work performance of nurses, which may affect emotional labor and the development of professional values. The purpose of this study was to explore the relationship between perceived organizational support and professional values of nurses, and the mediating role of emotional labor.Methods: A questionnaire survey was conducted on 1096 nurses in 3 tertiary hospitals in Wuhan from October2020 to Januray2021. The data were collected by a questionnaire consisting of demographic characteristics, the Emotional Labor Scale for Nurses, the nurses' Perceived Organizational Support Scale, and the Nursing Professional Values Scale (NPVS-R). Spearmen correlation analysis was used to test the relationship between variables. Predictor effects were tested using hierarchical multiple regressions. The structural equation model (SEM) was used to test the mediation effect of emotional labor on the pathway from perceived organizational support to professional values.Results: Perceived organizational support was positively correlated with emotional labor and professional values (r=0.513, p＜0.01；r=0.621, p＜0.01, respectively). Emotional labor and perceived organizational support were positive predictors of professional values (β=0.249, p＜0.001; β=0.486, p＜0.001, respectively). The association between perceived organizational support and professional values was mediated by emotional labor.Conclusions: Results showed that the importance of improving perceived organizational support to encourage nurses to engage in emotional labor and promote professional values. Improving organizational support and training nurses to engage in emotional labor through providing multiple support systems, establishing reasonable incentive mechanisms, and training nurses to regulate emotions can be effective ways to promote nurses' professional values.
Femoral Periprosthetic Fracture Treatment Using the Ortho-Bridge System: A Biomechanical Study
Authors: wang wen , Long Yuntao , Qi Yubin , Zuo Guilai , Zhang Qingjie , Liu Zhenlin 
Published: September 2021

Abstract
Background: We undertook a comparative biomechanical study of type B1 fractures around the femoral prosthesis following cemented hip arthroplasty using the Ortho-Bridge System (OBS) and a locking compression plate/locking attachment plate structure (LCP+LAP), and aimed to determine the effectiveness and advantages of the OBS when treating this fracture type. Methods: An OBS fixation model was designed based on OBS and LCP+LAP fixation characteristics. The LCP+LAP combination (Group A) and three different OBS combinations (Groups B, C, and D) were used to fix a B1 fracture model with a femoral periprosthetic fracture. Axial compression and torsion experiments were then performed using simple and comminuted fracture models. We conducted axial compression failure, model stiffness, and torsion angle tests, and tested the vertical load of final failure. Results: When simulating simple oblique fractures, no significant difference was found in terms of stiffness between the four groups in the axial compression experiment (P = 0.257). The torsion angle of the LCP+LAP system was significantly higher than that of the OBS (P < 0.05); however, there was no significant difference in the torsion angle between the OBS combinations (P > 0.05). Axial compression experimental data showed that stiffness in the three OBS combinations was higher than that in the LCP+LAP system (P = 0.000). Torsion angles of the three OBS combinations were smaller than those of the LCP+LAP system (P < 0.05). In the axial compression failure test, the fixed failure mode in the LCP+LAP system involved destruction of the contact cortex at the fracture site, while the failure modes in the three OBS combinations involved destruction of the contact cortex at the fracture site and the fracture around the screws above the osteotomy. Conclusion: Compared with the LCP+LAP, the OBS showed superior biomechanical results. Furthermore, the OBS has the advantage of multiple choices and high flexibility of combinations. Stress dispersion was helpful in avoiding internal fixation failure during early postoperative functional exercise.
Gal-3BP Levels in Hospitalized Patients Correlate With COVID-19
Authors: Gallo Valentina , ISERC Team , Gentile Roberta , Antonini Giovanni , Iacobelli Stefano 
Published: September 2021

Abstract
The ongoing Covid-19 pandemic disease is still lacking effective treatments and relying on a predictive diagnosis for early individuation of patients which will progress to a severe disease can be crucial. To this aim, the search and the identification of new molecular targets of inflammation and disease progression to be used as predictive biomarker of disease severity is important.In this work Gal-3BP was explored as a potential biomarker for COVID-19 severity. We found highly increased circulating levels of Gal-3BP in COVID-19 patients compared to healthy controls. Furthermore, the serum levels of Gal-3BP were higher in those “non severe” patients which progressed to a “severe” disease and correlated with levels of IL-6, a known marker of disease progression in COVID-19 patients. These results suggest that Gal-3BP could be a predictor of Covid-19 severity in early infected patients contributing to extend the panel of the other already known biomarkers associated to Covid-19 severity and progression.
Survival after Laparoscopic Radical Surgery for Early-stage Cervical Cancer in 1316 Consecutive Cases from a National Laparoscopic Training Center in China
Authors: Huang Yuhui , Cai Jing , Wang Hongbo , Dong Weihong , Zhang Yuan , Wang Shaohai , He Xiaoqi , Guo Jianfeng , Yang Shouhua , Wang Zehua 
Published: September 2021

Abstract
Background: A major concern about the Laparoscopy Approach to Cervical Cancer trial is the disparities in laparoscopic radical hysterectomy experience between the participating centers and the potential effects of the learning curve of minimally invasive surgery on the oncologic outcomes of patients. Thus, it is necessary to assess the survival of cervical cancer patients undergoing laparoscopy in a minimally invasive gynecology center.Methods: A consecutive series of patients undergoing first laparoscopic radical hysterectomy (LRH) for cervical cancer from May 2008 to December 2017 at a national laparoscopic training center were retrospectively analyzed. The overall survival (OS) and progression-free survival (PFS) were compared between groups.Results: In total, 1316 women with FIGO (2009) stage IA-IIB cervical cancer received LRH. Among them, 1114 (84.7%) were followed-up for 3 months or longer; the median follow-up period was 48 months (range, 3-144 months). In patients with stage IA, IB1 (≤ 2 cm), IB1 (> 2 cm), IB2, IIA1 and IIA2-IIB tumors, the 4-year PFS rates were 98.6%, 94.5%, 87.4%, 65.6%, 80.0% and 67.4%, respectively, and the 4-year OS rates were 98.6%, 96.8%, 91.1%, 77.4%, 85.6% and 76.2%, respectively. The 4-year PFS and OS were as high as 96.2% and 97.5%, respectively, in patients with squamous cell carcinoma of 2 cm or smaller in diameter. A stable high 4-year OS and PFS was achieved after completing 100 LRHs. In patients operated on by the same surgeon, an improvement in survival was observed after 40 LRHs. Conclusion: Favorable oncologic outcomes can be achieved in patients with IA-IB1 cervical cancer after LRH in a center with a high surgery volume.
Staged Surgical Reconstruction With Skin Expansion of A Marjolin’s Ulcer With Better Recovery: a Case Report
Authors: Xie Xudong , Hu Liangcong , Mi Bobin , Xue Hang , Panayi Adriana C. , Xiong Yuan , Chen Lang , Yan Chenchen , Lin Ze , Zhou Wu , Liu Guohui 
Published: September 2021

Abstract
Marjolin’s ulcers (MUs) are one of the most common tumors developed from non-healing wound with chronic inflammation or injury, specially burn scars, over many years. However, the therapy recommendations for MUs are not yet definitive. Here, we presented a case of 60-year-old man with a chronic non-healing infected wound related to MUs in the right knee. And, the wound made a better recovery after treatment with staged operation in combination with skin expansion.
Are "Clean" Cosmetic Products Really Clean? A Pilot Study on the Validity of Cosmetic Labeling
Authors: Phan Jeannie H. , Kyaw Khine K. , Tan Julia K. , Lam Emily Q. , Lin Cheng-Kuan 
Published: September 2021

Abstract
Background
As a result of increased demand for environmental and health-conscious cosmetics, retailers have increasingly marketed their products using terms such as “clean” or "non-toxic". Sephora, a popular beauty retailer, implemented a clean seal system to label and promote their products. This study aims to compare the toxicity concerns of clean vs. non-clean products by using the Environmental Working Group (EWG)'s Skin Deep framework.
Methods
EWG’s Skin Deep Framework was used to rank products based on their cancer, allergy and immunotoxicity, developmental and reproductive toxicity, and use-restriction concerns, with lower scores indicating a cleaner product (ranging 0–10). The distributions of EWG scores among clean and non-clean products were investigated and stratified by different types of products (i.e. fragrance, hair, makeup, or skincare). A multivariable linear regression model was further applied to evaluate the association between EWG scores and clean seals, adjusting by types of products, level of toxicity concerns.
Results
356 products were screened, including 180 (50.56%) clean products and 176 (49.44%) non-clean products. Clean products yielded a higher percentage of low hazard ingredients compared to non-clean products. EWG scores are positively correlated with the levels of toxicity concern for cancer, allergy and immunotoxicity, respectively. Clean products are also associated with a lower EWG score by 0.71 in the regression model. Fragrance products are most hazardous, with a 2.42 increase in EWG score.
Conclusions
Products under the binary “clean beauty” labeling system at Sephora may not necessarily capture the nuances of EWG’s ten-point scoring system and various dimensions of health concerns. It may be insufficient for consumers to solely rely on the presence of the clean seal when purchasing beauty products. Consulting multiple frameworks and sources to inform decision-making is crucial in addressing knowledge gaps. Further research and increased data availability from EWG’s database are necessary as well as public education on the application of Sephora’s clean seal.
Breast Cancer Combined with Contralateral Neck Lymph Node Metastasis. Case Report
Authors: Zhong Xiaoxiao , Ding Fengjiao , Qian Liyuan , Wu Wei , Wen Yanguang , Ding Boni 
Published: September 2021

Abstract
Background: Contralateral neck lymph node metastasis is rare for primary breast cancer. Its clinical stage and treatment principles are lack of authoritative guidelines. A 30-year-old breast cancer patient with contralateral neck lymph node metastasis is presented. The clinical treatment is discussed combined with current research.Case presentation: A 30-year-old woman presented with a right breast mass for 5 months and left neck lymph node enlargement for 5 days. The mammography showed a 33mm*14.3mm mass in the inner quadrant of right breast. The ultrasound showed several hypoechoic nodules on the left side of the neck. Rapid intraoperative pathological examination diagnosed right breast malignant tumor and poorly differentiated carcinoma of the left cervical lymph nodes. Then the right mastectomy was performed immediately. The patient was scheduled to administer chemotherapy, molecular targeted therapy, radiotherapy and endocrinotherapy after operation. The long-term efficacy remains to be seen.Conclusion: The infrequent presentation of breast cancer with metastasis to the contralateral neck lymph node can be challenged for standard therapies.
Semiquantitative Assessment of 99mTc-MIBI Uptake in Parathyroids of Secondary Hyperparathyroidism Patients from Chronic Renal Failure
Authors: Yu Dafu , Zou Lin , Jin Yao , Wei Mingxiang , Wu Xiaoqun , Zuo Lingjing , Zhu Di , Wu Mingkang , Wang Meifang , Li Haochen , Jiang Yong 
Published: September 2021

Abstract
Purpose Basing on semiquantitative assessment of 99mTc-MIBI uptake in parathyroids of secondary hyperparathyroidism (SHPT) patients from chronic renal failure, objective guidance could be given to improve the qualitative diagnosis accuracy of MIBI uptake.Methods MIBI uptake intensiveness was semiquantitatively calculated with software ImageJ. MIBI uptake intensiveness and clinical indices were compared in 3-level grouping method consisting of slight (group 1), medium (group 2) and high (group 3) MIBI uptake groups and 2-level grouping method consisting of insignificant and significant MIBI uptake groups.Results Patient age, renal failure course, hemodialysis vintage, glomerular filtration rate (GFR), serum parathyroid hormone (PTH) and alkaline phosphatase (AKP) were positively, but serum uric acid (UA) was negatively, significantly related to MIBI uptake intensiveness; patient age was negatively, but serum phosphorus (P) and calcium (Ca) ´ P were positively, significantly related to MIBI washout; oral administration of calcitriol and calcium would significantly reduce MIBI uptake and washout. MIBI uptake tendency might alter during specified course. In 3-level grouping method, such 7 indices as the MIBI uptake intensiveness, renal failure course, hemodialysis vintage, serum AKP, Ca, cysteine proteinase inhibitor C and PTH were comparable between group 1 and 2, but were significantly different between group 1 and 3, and between group 2 and 3. In 2-level grouping method, above 7 indices plus blood urine nitrogen (BUN)/Creatinine were all significantly different between insignificant and significant group with these indices except BUN/Creatinine being greater in significant group than in insignificant group. All above significant relations or differences were with p < 0.05.Conclusions Patient age, renal failure course, hemodialysis vintage, GFR, serum PTH, AKP, UA, phosphorus and Ca ´ P, oral administration of calcitriol and calcium, and parathyroids themselves could significantly influence MIBI uptake in parathyroids of SHPT patients. 2-level grouping method should be adopted to qualitatively diagnosis MIBI uptake.
Fault diagnosis of gearbox based on improved polynomial adaptive chirp mode decomposition algorithm
Authors: Cui Lingli , Peng Yuchuan , LIU Tongtong 
Published: September 2021

Abstract
The adaptive chirp mode decomposition (ACMD) has good time-frequency representation results in analyzing chirp signals, while there is a time-frequency ambiguity problem in the analysis of variable speed planetary gearbox vibration signals. To address this problem, a planetary gearbox fault diagnosis method based on improved polynomial adaptive chirp mode decomposition wavelet is proposed (IPACMD). Using Adaptive chirp mode decomposition, the amplitude and instantaneous frequency of multiple signal components are estimated; To avoid over-decomposition to generate spurious signal components, the similarity conditional entropy is used to optimize the adaptive chirp mode decomposition threshold ;The polynomial chirp transform (PCT) using a polynomial function instead of the linear chirp kernel in the chirp transform to improve the time-frequency aggregation of the instantaneous frequency curve of each signal component and output high-resolution time-frequency representation results. Compared with the original method, the proposed method has better time-frequency aggregation and is more effective for the analysis of variable speed planetary gearbox vibration signals. The simulation and experimental study results show that the method can effectively identify the frequency components and time-frequency characteristics of the variable-speed planetary gearbox vibration signal and realize the fault diagnosis of the planetary gearbox.