bluuebunny/crossref_metadata_2025_split huggingface dataset:
A classification algorithm based on multi-dimensional fuzzy transforms
Authors: Di Martino Ferdinando , Sessa Salvatore 
Published: June 2021

AbstractWe present a new classification algorithm for machine learning numerical data based on direct and inverse fuzzy transforms. In our previous work fuzzy transforms were used for numerical attribute dependency in data analysis: the multi-dimensional inverse fuzzy transform was used to approximate the regression function. Also here the classification method presented is based on this operator. Strictly speaking, we apply the K-fold cross-validation algorithm for controlling the presence of over-fitting and for estimating the accuracy of the classification model: for each training (resp., testing) subset an iteration process evaluates the best fuzzy partitions of the inputs. Finally, a weighted mean of the multi-dimensional inverse fuzzy transforms calculated for each training subset (resp., testing) is used for data classification. We compare this algorithm on well-known datasets with other five classification methods.
Asthma-Related Emergency Department Visits in North Carolina Following Hurricane Irene
Authors: Cowan Kristen N. , Pennington Audrey F. , Sircar Kanta , Flanders W. Dana 
Published: June 2021

Abstract

Objective:
Previous research suggests that people with asthma may experience a worsening of symptoms following hurricanes due to changes in environmental exposures, discontinuity in chronic disease management, and stress. The objective of this study was to estimate changes in asthma-related emergency department (ED) visits in North Carolina following Hurricane Irene, which made landfall in August 2011.

Methods:
Changes in asthma-related ED visits in September to December of 2010 and 2011 were examined using data from the Healthcare Cost and Utilization Project State Emergency Department and Inpatient Databases. A Poisson generalized linear model was used to estimate the association between Federal Emergency Management Agency disaster declarations following Hurricane Irene and county-level asthma-related ED visits controlling for month, year, and county.

Results:
Following Hurricane Irene, disaster declarations were made for 38 of 100 counties in North Carolina. In September 2010, the rate of asthma-related ED visits for North Carolina was 6 per 10,000 person-months. In September 2011, rates of asthma-related ED visits were similar in counties with and without disaster declarations (7 and 5 per 10,000 person-months, respectively). When adjusting for covariates, there was little or no difference in the rate of asthma ED visits before and after the hurricane between counties with and without a disaster declaration (rate ratio {RR} [95% confidence interval {CI}] = 1.02[0.97, 1.08]).

Conclusions:
Although risk factors for asthma exacerbations increase following hurricanes, these results found little evidence of an increase in asthma-related ED visits in North Carolina following Hurricane Irene.
Senecan Tragedy: Twelve Propositions
Authors: Boyle A. J. 
Published: June 2021

I begin by stating what Senecan tragedy is not. Senecan tragedy is not a series of declamations cast into dramatic form, as Leo claimed. It is not purely verbal drama divorced from the inner psychological realities of character, as Eliot claimed. It is not character-static drama, incohesive, structureless, lifeless and monotonously versified, as Mackail and others have claimed. It is not Stoic propaganda, as Marti claimed. It is not recitation drama, if by recitation drama is meant drama to be recited by a single speaker and essentially unstageable, as Zwierlein claims. It is not a tissue of hackneyed commonplaces, as Ogilvie claimed, nor an artificial imitation of Greek tragedy, as Beare claimed; nor is it contemptible as literature, as Summers and most nineteenth and early twentieth century critics have claimed.What is Senecan tragedy? This essay presents twelve propositions, each of which isolates a characterising property of Senecan tragedy important for the understanding of it as literary and cultural artefact. These twelve propositions constitute neither an exhaustive list of such properties nor an analysis of genre. The latter question, however, I leave not to contemporary theory, but to the Codex Etruscus and the Elizabethans.
Informal caregivers of older Muslims diagnosed with cancer: A portrait of depression, social support, and faith
Authors: Baider Lea , Goldzweig Gil , Jacobs Jeremy M. , Ghrayeb Ibtisam M. , Sapir Eli , Rottenberg Yakir 
Published: June 2021

AbstractObjectiveIslamic population constitute more than 20% of the world population and is growing rapidly. Nevertheless, data concerning informal caregiving to older Muslim patients diagnosed with cancer are scarce. Improving the well-being of caregivers is a vital step to optimal care for the patients themselves throughout the Muslim community and the world. This study focuses on a sample of Palestinian caregivers of older Muslim patients diagnosed with cancer living in East Jerusalem, the West Bank, and Gaza. The study aims to describe the socio-demographic characteristics of the caregivers and to understand their social support, and identify predictors of caregivers’ depression.MethodsA cross-sectional study of a convenience sample of 99 dyads of Palestinian patients (age ≥65) and their informal caregivers. Depression and social support were measured using the five items of the Geriatric Depression Scale and the Cancer Perceived Agents of Social Support questionnaire.ResultsCaregivers were most frequently adult children (52%) or spouses (32%), with male patients cared for by spouses (47.5%) or sons (32%), and female patients by daughters (50%). Clinical levels of depression were reported by 76% of the caregivers and 85% of patients. The significant predictors of caregiver depression were female gender, lower education, lower perceived social support from spouse and family, and higher perceived support from faith.Significance of resultsHealthcare providers serving the study population should determine the position and role of the caregiver within the social and family structure surrounding the patients’ families. This understanding may facilitate overcoming barriers to effective and meaningful social support.
The contractualization of fiscal and parliamentary sovereignty: Towards a private international finance architecture?
Authors: Bantekas Ilias 
Published: June 2021

AbstractA state should be deemed to be enjoying fiscal sovereignty where it is effectively empowered, without pressure or coercion, to make all policy decisions required to run the state machinery and satisfy the fundamental needs of its people (at the very least), both individual and collective. A state’s effective policy and decision-making power is effectively curtailed where: (1) it has been substituted in these functions by a third state or an organ of that state; (2) it is prevented from taking a particular action, such as unilateral default; (3) it is forced to violate fundamental domestic laws, including its constitution or the result of a referendum; or (4) external pressure is exerted against its government and institutions, with the aim of creating volatility and uncertainty concerning its finances so it succumbs to such pressure.
Diagnostic and prognostic potential of the proteomic profiling of serum-derived extracellular vesicles in prostate cancer
Authors: Signore Michele , Alfonsi Romina , Federici Giulia , Nanni Simona , Addario Antonio , Bertuccini Lucia , Aiello Aurora , Di Pace Anna Laura , Sperduti Isabella , Muto Giovanni , Giacobbe Alessandro , Collura Devis , Brunetto Lidia , Simone Giuseppe , Costantini Manuela , Crinò Lucio , Rossi Stefania , Tabolacci Claudio , Diociaiuti Marco , Merlino Tania , Gallucci Michele , Sentinelli Steno , Papalia Rocco , De Maria Ruggero , Bonci Désirée 
Published: June 2021

AbstractExtracellular vesicles (EVs) and their cargo represent an intriguing source of cancer biomarkers for developing robust and sensitive molecular tests by liquid biopsy. Prostate cancer (PCa) is still one of the most frequent and deadly tumor in men and analysis of EVs from biological fluids of PCa patients has proven the feasibility and the unprecedented potential of such an approach. Here, we exploited an antibody-based proteomic technology, i.e. the Reverse-Phase Protein microArrays (RPPA), to measure key antigens and activated signaling in EVs isolated from sera of PCa patients. Notably, we found tumor-specific protein profiles associated with clinical settings as well as candidate markers for EV-based tumor diagnosis. Among others, PD-L1, ERG, Integrin-β5, Survivin, TGF-β, phosphorylated-TSC2 as well as partners of the MAP-kinase and mTOR pathways emerged as differentially expressed endpoints in tumor-derived EVs. In addition, the retrospective analysis of EVs from a 15-year follow-up cohort generated a protein signature with prognostic significance. Our results confirm that serum-derived EV cargo may be exploited to improve the current diagnostic procedures while providing potential prognostic and predictive information. The approach proposed here has been already applied to tumor entities other than PCa, thus proving its value in translational medicine and paving the way to innovative, clinically meaningful tools.
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3
Authors: Santini Laura , Halbritter Florian , Titz-Teixeira Fabian , Suzuki Toru , Asami Maki , Ma Xiaoyan , Ramesmayer Julia , Lackner Andreas , Warr Nick , Pauler Florian , Hippenmeyer Simon , Laue Ernest , Farlik Matthias , Bock Christoph , Beyer Andreas , Perry Anthony C. F. , Leeb Martin 
Published: June 2021

AbstractIn mammalian genomes, differentially methylated regions (DMRs) and histone marks including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes are asymmetrically inherited to control parentally-biased gene expression. However, neither parent-of-origin-specific transcription nor imprints have been comprehensively mapped at the blastocyst stage of preimplantation development. Here, we address this by integrating transcriptomic and epigenomic approaches in mouse preimplantation embryos. We find that seventy-one genes exhibit previously unreported parent-of-origin-specific expression in blastocysts (nBiX: novel blastocyst-imprinted expressed). Uniparental expression of nBiX genes disappears soon after implantation. Micro-whole-genome bisulfite sequencing (µWGBS) of individual uniparental blastocysts detects 859 DMRs. We further find that 16% of nBiX genes are associated with a DMR, whereas most are associated with parentally-biased H3K27me3, suggesting a role for Polycomb-mediated imprinting in blastocysts. nBiX genes are clustered: five clusters contained at least one published imprinted gene, and five clusters exclusively contained nBiX genes. These data suggest that early development undergoes a complex program of stage-specific imprinting involving different tiers of regulation.
A dynamic basal complex modulates mammalian sperm movement
Authors: Khanal Sushil , Leung Miguel Ricardo , Royfman Abigail , Fishman Emily L. , Saltzman Barbara , Bloomfield-Gadêlha Hermes , Zeev-Ben-Mordehai Tzviya , Avidor-Reiss Tomer 
Published: June 2021

AbstractReproductive success depends on efficient sperm movement driven by axonemal dynein-mediated microtubule sliding. Models predict sliding at the base of the tail – the centriole – but such sliding has never been observed. Centrioles are ancient organelles with a conserved architecture; their rigidity is thought to restrict microtubule sliding. Here, we show that, in mammalian sperm, the atypical distal centriole (DC) and its surrounding atypical pericentriolar matrix form a dynamic basal complex (DBC) that facilitates a cascade of internal sliding deformations, coupling tail beating with asymmetric head kinking. During asymmetric tail beating, the DC’s right side and its surroundings slide ~300 nm rostrally relative to the left side. The deformation throughout the DBC is transmitted to the head-tail junction; thus, the head tilts to the left, generating a kinking motion. These findings suggest that the DBC evolved as a dynamic linker coupling sperm head and tail into a single self-coordinated system.
Ni-catalyzed hydroaminoalkylation of alkynes with amines
Authors: Yao Wei-Wei , Li Ran , Chen Hao , Chen Ming-Kai , Luan Yu-Xin , Wang Yi , Yu Zhi-Xiang , Ye Mengchun 
Published: June 2021

AbstractAllylic amines are versatile building blocks in organic synthesis and exist in bioactive compounds, but their synthesis via hydroaminoalkylation of alkynes with amines has been a formidable challenge. Here, we report a late transition metal Ni-catalyzed hydroaminoalkylation of alkynes with N-sulfonyl amines, providing a series of allylic amines in up to 94% yield. Double ligands of N-heterocyclic carbene (IPr) and tricyclohexylphosphine (PCy3) effectively promote the reaction.
Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors
Authors: Schneider Marcel A. , Linecker Michael , Fritsch Ralph , Muehlematter Urs J. , Stocker Daniel , Pestalozzi Bernhard , Samaras Panagiotis , Jetter Alexander , Kron Philipp , Petrowsky Henrik , Nicolau Claude , Lehn Jean-Marie , Humar Bostjan , Graf Rolf , Clavien Pierre-Alain , Limani Perparim 
Published: June 2021

AbstractHypoxia is prominent in solid tumors and a recognized driver of malignancy. Thus far, targeting tumor hypoxia has remained unsuccessful. Myo-inositol trispyrophosphate (ITPP) is a re-oxygenating compound without apparent toxicity. In preclinical models, ITPP potentiates the efficacy of subsequent chemotherapy through vascular normalization. Here, we report the results of an unrandomized, open-labeled, 3 + 3 dose-escalation phase Ib study (NCT02528526) including 28 patients with advanced primary hepatopancreatobiliary malignancies and liver metastases of colorectal cancer receiving nine 8h-infusions of ITPP over three weeks across eight dose levels (1'866-14'500 mg/m2/dose), followed by standard chemotherapy. Primary objectives are assessment of the safety and tolerability and establishment of the maximum tolerated dose, while secondary objectives include assessment of pharmacokinetics, antitumor activity via radiological evaluation and assessment of circulatory tumor-specific and angiogenic markers. The maximum tolerated dose is 12,390 mg/m2, and ITPP treatment results in 32 treatment-related toxicities (mostly hypercalcemia) that require little or no intervention. 52% of patients have morphological disease stabilization under ITPP monotherapy. Following subsequent chemotherapy, 10% show partial responses while 60% have stable disease. Decreases in angiogenic markers are noted in ∼60% of patients after ITPP and tend to correlate with responses and survival after chemotherapy.
Evolution and expansion of Li concentration gradient during charge–discharge cycling
Authors: Chae Byeong-Gyu , Park Seong Yong , Song Jay Hyok , Lee Eunha , Jeon Woo Sung 
Published: June 2021

AbstractTo improve the performance of Li-ion batteries (LIBs), it is essential to understand the behaviour of Li ions during charge–discharge cycling. However, the analytical techniques for observing the Li ions are limited. Here, we present the complementary use of scanning transmission electron microscopy and atom probe tomography at identical locations to demonstrate that the evolution of the local Li composition and the corresponding structural changes at the atomic scale cause the capacity degradation of Li(Ni0.80Co0.15Mn0.05)O2 (NCM), an LIB cathode. Using these two techniques, we show that a Li concentration gradient evolves during cycling, and the depth of the gradient expands proportionally with the number of cycles. We further suggest that the capacity to accommodate Li ions is determined by the degree of structural disordering. Our findings provide direct evidence of the behaviour of Li ions during cycling and thus the origin of the capacity decay in LIBs.
Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain
Authors: Tan Timothy J. C. , Yuan Meng , Kuzelka Kaylee , Padron Gilberto C. , Beal Jacob R. , Chen Xin , Wang Yiquan , Rivera-Cardona Joel , Zhu Xueyong , Stadtmueller Beth M. , Brooke Christopher B. , Wilson Ian A. , Wu Nicholas C. 
Published: June 2021

AbstractSince the COVID-19 pandemic onset, the antibody response to SARS-CoV-2 has been extensively characterized. Antibodies to the receptor binding domain (RBD) on the spike protein are frequently encoded by IGHV3-53/3-66 with a short complementarity-determining region (CDR) H3. Germline-encoded sequence motifs in heavy chain CDRs H1 and H2 have a major function, but whether any common motifs are present in CDR H3, which is often critical for binding specificity, is not clear. Here, we identify two public clonotypes of IGHV3-53/3-66 RBD antibodies with a 9-residue CDR H3 that pair with different light chains. Distinct sequence motifs on CDR H3 are present in the two public clonotypes that seem to be related to differential light chain pairing. Additionally, we show that Y58F is a common somatic hypermutation that results in increased binding affinity of IGHV3-53/3-66 RBD antibodies with a short CDR H3. These results advance understanding of the antibody response to SARS-CoV-2.
Breaking the acoustic diffraction limit with an arbitrary shape acoustic magnifying lens
Authors: Abdolali Ali , Barati Sedeh Hooman , Fakheri Mohammad Hosein , Shen Chen , Sun Fei 
Published: June 2021

AbstractBased on the transformation acoustics methodology, the design principle for achieving an arbitrary shape magnifying lens (ASML) is proposed. Contrary to the previous works, the presented ASML is competent of realizing far-field high resolution images and breaking the diffraction limit, regardless of the position of the utilized sources. Therefore, objects locating within the designed ASML can be properly resolved in the far-field region. It is shown that the obtained material through the theoretical investigations becomes an acoustic null medium (ANM), which has recently gained a significant attention. Besides the homogeneity of ANM, which makes it an implementable material, it is also independent of the perturbation in the geometry of the lens, in such a way that the same ANM can be used for different structural topologies. The obtained ANM has been implemented via acoustics unit cells formed by membranes and side branches with open ends and then was utilized to realize an ASML with the aid of effective medium theory. It is shown that the far-field results of an ideal ASML abide well with the results of the implemented sample, validating the proposed design principle. The presented acoustic magnifying lens has a wide spectrum of possible applications ranging from medical imaging, and biomedical sensors to focused ultrasound surgery.
Comprehensive analysis of bacteriocins in Streptococcus mutans
Authors: Watanabe Atsuko , Kawada-Matsuo Miki , Le Mi Nguyen-Tra , Hisatsune Junzo , Oogai Yuichi , Nakano Yoshio , Nakata Masanobu , Miyawaki Shouichi , Sugai Motoyuki , Komatsuzawa Hitoshi 
Published: June 2021

AbstractStreptococcus mutans produces bacteriocins that show antibacterial activity against several bacteria. However, comprehensive analysis of these bacteriocins has not been well done. In this study, we isolated 125 S. mutans strains from volunteers and determined their whole genome sequence. Based on the genome analysis, the distribution of each bacteriocin gene (mutacins I-IV, K8 and Smb) was investigated. We found 17, 5, and 2 strains showing 100% matches with mutacin I, mutacin II and mutacin III, respectively. Five mutacin III-positive strains had 2 mismatches compared to mature mutacin III. In 67 mutacin IV-positive strains, 38 strains showed 100% match with mutacin IV, while 29 strains showed some variations. In 23 mutacin K8- and 32 mutacin Smb-positive strains, all except one mutacin K8-positive strain showed 100% match with the mature peptides. Among 125 strains, 84 (65.1%), 26 (20.2%), and 5 (3.9%) strains were positive for one, two and three bacteriocin genes, respectively. Then, the antibacterial activity against oral streptococci and other oral bacterial species was investigated by using bacteriocin gene single-positive strains. Each bacteriocin gene-positive strain showed a different pattern of antibacterial activity. These results speculate that individual S. mutans strains may affect the bacterial composition of dental plaques.
Structural transformation between rutile and spinel crystal lattices in Ru–Co binary oxide nanotubes: enhanced electron transfer kinetics for the oxygen evolution reaction
Authors: Yu Areum , Kim Myung Hwa , Lee Chongmok , Lee Youngmi 
Published: June 2021

A variety of binary RuxCo1−xOy (x = 0.19, 0.33, 0.47, 0.64 and 0.77) were synthesized via electrospinning and subsequent calcination, and investigated for OER electrocatalytic activity in 1.0 M HClO4 aqueous solution.
Research on the Construction of E-commerce Platform for Poverty Alleviation Products Based on Internet
Authors: Qiao Xinjiang , Ai Weiping , Chen Xuan , Feng Ximing 
Published: June 2021

With the development of the current Internet, e-commerce has also shown a vigorous vitality. The development of China’s new poverty alleviation model is also closely related to the Internet e-commerce platform. The construction of e-commerce platform has gradually become an important path to get rid of poverty in rural areas. Through a series of analysis, this paper summarizes some current situation of e-commerce development and some effects achieved by e-commerce platform in poverty alleviation, and summarizes the experience and poverty alleviation model of some domestic e-commerce platforms. Finally, the feasibility of the current agricultural products e-commerce poverty alleviation model is studied and discussed.
Subject: Research on the Reform of Ideological and Political Education for College Students in Jiangxi Province in 2020
Perioperative Medizin in der Viszeralchirurgie beim alten Patienten aus anästhesiologischer Perspektive
Authors: Söhle Martin , Coburn Mark 
Published: June 2021

ZusammenfassungDer demografische Wandel führt zu einer zunehmenden Anzahl alter Patienten sowohl in unserer Gesellschaft als auch im Krankenhaus. Mit zunehmendem Alter steigt nicht nur die Anzahl der Vorerkrankungen, sondern auch die postoperative Komplikationsrate und Mortalität. Letztlich ist aber nicht das Alter ausschlaggebend, sondern der Zustand des Patienten und seine Kapazität, sich den körperlichen und mentalen Herausforderungen eines operativen Eingriffs zu stellen. Besonders von Komplikationen bedroht sind gebrechliche Patienten und eine wesentliche – als Prähabilitation – bezeichnete Strategie besteht darin, diese durch körperliches und mentales Training sowie Ernährungsberatung bereits präoperativ in einen besseren Zustand zu versetzen. Das Delir gehört zu den häufigsten postoperativen Komplikationen. Maßnahmen, wie der Verzicht auf eine Prämedikation mit Benzodiazepinen, die Messung der Narkosetiefe, der Verzicht auf langwirksame Opioide, die Durchführung von Fast-Track
Surgery sowie die zügige postoperative Bereitstellung von Brille/Hörgerät können das Delirrisiko reduzieren. Eine enge interdisziplinäre Absprache zwischen Chirurgen, Anästhesisten, Geriatern und Physiotherapeuten ist wesentlich, um das perioperative Vorgehen miteinander abzustimmen und das perioperative Risiko für alte Patienten zu reduzieren.