bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acupuncture Treatments for Post-stroke Depression: A Systematic Review and Network Meta-analysis
Authors: Ching Lam Wai , Li Hui Juan , Guo Jianwen , Yao Liang , Chau Janita , Lo Suzanne , Yuen Chun Sum , Ng Bacon Fung Leung , Yu Edwin Chau-Leung , Bian Zhaoxiang , Lau Alexander Y , Zhong Linda LD 
Published: October 2021

Abstract
Background: Depression is one of the most common complications after stroke, with a prevalence of 30-33%. Patients with post-stroke depression (PSD) usually experience anxiety, hopelessness, and insomnia, which have a negative impact on their daily activities and post-stroke rehabilitation. In this review, we aimed to explore the impact of acupuncture in alleviating symptoms of PSD and to evaluate the difference in effectiveness between acupuncture combined with pharmacotherapies and various non-pharmacotherapies in order to provide guides and advice for clinical personnel. Methods: Six databases (Cochrane Library, PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang Database, Chongqing VIP Database) and two clinical trials registration platforms were searched from inception to May 2021. Randomized clinical trials (RCTs) comparing needle-based acupuncture with pharmacotherapy, and other non-pharmacotherapy or invalid group were included. Two independent reviewers identified eligible studies. Two reviewers independently abstracted and recorded data into a pre-made form. A Bayesian network meta-analysis (NMA) was conducted to assess and compare different techniques using RStudio 3.6.0. The primary outcome was the change in scores of scales measuring depressive symptoms. The secondary outcomes were changes in serotonin levels and in quality of life. Results: Fifty-nine RCTs were included. The results of this NMA showed that compared with western medicine (WM), acupuncture alone or with repetitive transcranial magnetic stimulation (RTMS), Traditional Chinese medicine (TCM) alone or with WM, were superior for alleviating depression symptoms. Compared to Usual Care, acupuncture alone or plus other therapies could significantly decrease scores of the Hamilton Depression Rating scale. However, there was no significant difference found among acupuncture, WM, TCM with AC plus any of other treatment.Conclusions: The results of this study indicate that acupuncture alone or combined with other therapies appear to be effective in improving depression symptoms of stroke survivors. Moreover, in comparison with WM, acupuncture alone or plus RTMS, TCM, TCM with WM, or WM, were more effective in improving depression symptoms. Also, acupuncture with RTMS seems to be the most effective with the highest probability.
Ectoderm-Derived Frontal Bone Mesenchymal Stem Cells Promote Traumatic Brain Injury Recovery by Alleviating Neuroinflammation and Glutamate Excitotoxicity
Authors: Qin Qiaozhen , Wang Ting , Xu Zhenhua , Liu Shuirong , Zhang Heyang , Du Zhangzhen , Wang Jianing , Wang Yadi , Wang Zhenning , Yuan Shanshan , Wu Jiamei , He Wenyan , Wang changzhen , Yan Xinlong , Wang Yan , Jiang Xiaoxia 
Published: October 2021

Abstract
Traumatic brain injury (TBI) leads to cell and tissue impairment, as well as functional deficits. Stem cells promote structural and functional recovery and thus are considered as a promising therapy for various nerve injuries. Here, we aimed to investigate the role of ectoderm-derived frontal bone mesenchymal stem cells (FbMSCs) in promoting cerebral repair and functional recovery in a murine TBI model. FbMSCs showed fibroblast like morphology and osteogenic differentiation capacity. FbMSCs were CD105, CD29 positive and CD45, CD31 negative. Different from mesoderm-derived MSCs, FbMSCs highly expressed ectoderm-specific transcription factor Tfap2β and growth factor FGF1. FbMSC application significantly ameliorated the behavioral deficits of TBI mice and promoted neural regeneration. Immunofluorescence staining and qRT-PCR data revealed that microglial activation and astrocyte polarization to the A1 phenotype were suppressed by FbMSC application. In addition, FGF1 secreted from FbMSCs enhanced glutamate transportation by astrocytes and alleviated the cytotoxic effect of excessive glutamate on neurons. Therefore, MSCs with characteristics of FbMSCs might be good candidates for TBI therapy.
A New Approach for Solving the Inverse Kinematics of Continuum Robot Based on Piecewise Constant Curvature Model
Authors: Wu Haoran , Yu Jingjun , Pan Jie , Pei Xu 
Published: October 2021

Abstract
The inverse kinematics of continuum robot is an important factor to guarantee the motion accuracy. How to construct a concise inverse kinematics model is very essential for the motion control of continuum robot. In this paper, a new method for solving the inverse kinematics of continuum robot is proposed based on the geometric and numerical method. Assumed that the deformation of the continuum robot is Piecewise Constant Curvature model (PCC), the envelope surface of the continuum robot based on single-segment is modeled and calculated. The clustering method is used to calculate the intersection of the curves. Then, a distinct sequence is designed for solving the inverse kinematics of continuum robot, and it is also suitable for the multi-segment continuum robots in space. Finally, the accuracy of the inverse kinematics algorithm is verified by the simulation and numerical experiment. The experiment results illustrate that this algorithm is with higher accuracy compared with the Jacobian iterative algorithm.
Do Information And Communications Technology (ICT) And Financial Development Contribute To Economic Diversification? Evidence From Sub-Saharan Africa
Authors: Owolabi Oluwarotimi Ayokunnu , Adedeji Adedayo Oluseun , Aderounmu Busayo , Oku Asa-Ruth Oboko , Ogunbiyi Toun 
Published: October 2021

Abstract
This study based on a panel of 37 Sub-Saharan Africa countries over the period of 2000 -2018 explores the effect of a number of ICT variables namely Fixed broad band, fixed line telephone, ICT imports, internet, mobile, and secure internet servers, and financial development measured by private sector domestic credit to GDP on economic diversification as measured by a computed Herfindahl Hirschman Index of Economic diversification. All data except rule of law were sourced from World Bank World Development Indicators, while rule of law was sourced from World Bank World Governance indicators. Model estimation was performed using pooled ordinary least squares regression, panel data fixed effects regression, and Generalised Method of Moments (GMM) regression. The results from findings indicated that the ICT variables, fixed line telephone, and ICT imports significantly reduced economic diversification, while internet use and mobile use were insignificant for boosting economic diversification, and fixed broadband and secure internet servers were insignificant in adversely affecting economic diversification. As regards financial development, it was insignificant in boosting economic diversification of SSA countries. The study recommended amongst others that Individuals in SSA countries should have improved access to ICT devices and governments’ should ensure adequate provision of quality ICT infrastructureJEL classification: C23, G10, G21, O11, O33, O55
Nanofactory for Metabolic and Chemodynamic Therapy: Pro-Tumor Lactate Trapping and Anti-Tumor ROS Transition
Authors: He Ruiqing , Zang Jie , Zhao Yuge , Liu Ying , Ruan Shuangrong , Zheng Xiao , Chong Gaowei , Xu Dailin , Yang Yan , Yang Yushan , Zhang Tingting , Gu Jingjing , Dong Haiqing , Li Yongyong 
Published: October 2021

Abstract
Lactate plays a critical role in tumorigenesis, invasion and metastasis. Exhausting lactate in tumors holds great promise for the reversal of the immunosuppressive tumor microenvironment (TME). Herein, we report on a “lactate treatment plant” (i.e., nanofactory) that can dynamically trap pro-tumor lactate and in situ transformation into anti-tumor cytotoxic reactive oxygen species (ROS) for a synergistic chemodynamic and metabolic therapy. To this end, lactate oxidase (LOX) was nano-packaged by cationic polyethyleneimine (PEI), assisted by a necessary amount of copper ions (PLNPCu). As a reservoir of LOX, the tailored system can actively trap lactate through the cationic PEI component to promote lactate degradation by two-fold efficiency. More importantly, the byproducts of lactate degradation, hydrogen peroxide (H2O2), can be transformed into anti-tumor ROS catalyzing by copper ions, mediating an immunogenic cell death (ICD). With the remission of immunosuppressive TME, ICD process effectively initiated the positive immune response in 4T1 tumor model (88% tumor inhibition). This work provides a novel strategy that rationally integrates metabolic therapy and chemodynamic therapy (CDT) for combating tumors.
Decreased Thalamic Monoamine Availability in Drug-Induced Parkinsonism
Authors: Oh Yoon-Sang , Yoo Sang-Won , Lyoo Chul Hyoung , Kim Joong-Seok 
Published: October 2021

Abstract
Drug-induced parkinsonism (DIP) is caused by a dopamine receptor blockade and is a major cause of misleading diagnosis of Parkinson’s disease (PD). Striatal dopamine activity has been investigated widely in DIP; however, most studies with dopamine transporter imaging have focused on the clinical characteristics and prognosis. This study investigated differences in striatal subregional monoamine availability among patients with DIP, normal controls, and patients with early PD. Thirty-five DIP patients, the same number of age-matched PD patients, and 46 healthy controls were selected for this study. Parkinsonian motor status was examined. Brain magnetic resonance imaging and positron emission tomography with 18F-N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane were performed, and the regional standardized uptake values were analyzed with a volume-of-interest template and compared among the groups. Females were more predominant in the DIP group than in the PD group. Parkinsonian motor symptoms were similar in the DIP and PD groups. Monoamine availability in the thalamus of the DIP group was lower than that of the normal controls and similar to that of the PD group. In other subregions (putamen, globus pallidus, and ventral striatum), monoamine availability in the DIP group and normal controls did not differ and was higher than that in the PD group. These findings suggest that low monoamine availability in the thalamus could be an imaging biomarker of DIP.
Increased hippocampal-inferior temporal cortex white matter connectivity following donepezil treatment in patients with mild cognitive impairment: A diffusion tensor probabilistic tractography study
Authors: Kim Gwang-Won , Park Kwangsung , Jeong Gwang-Woo 
Published: October 2021

Abstract
The incidence of Alzheimer’s disease (AD) has been increasing each year; however, few methods are available to identify the effects of treatment for AD. Defective hippocampus has been associated with mild cognitive impairment (MCI), an early stage of AD. However, the effect of donepezil treatment on hippocampus-related networks is unknown. The purpose of this study was to evaluate the hippocampal white matter (WM) connectivity following donepezil treatment in patients with MCI using probabilistic tractography, and to further determine the WM integrity and changes in brain volume. Magnetic resonance imaging and diffusion tensor imaging (DTI) data of patients with MCI before and after 6-month donepezil treatment were acquired. Volumes and DTI scalars of 11 regions of interest comprising the frontal and temporal cortices and subcortical regions were measured. Seed-based structural connectivity analyses were focused on the hippocampus. Compared with healthy controls, patients with MCI showed significantly decreased hippocampal volume and WM connectivity with the superior frontal gyrus, as well as increased mean diffusivity (MD) and radial diffusivity (RD) in the amygdala (p < 0.05, Bonferroni-corrected). After six months of donepezil treatment, patients with MCI showed increased hippocampal-inferior temporal gyrus (ITG) WM connectivity (p < 0.05, Bonferroni-corrected), which was normalized to the healthy control. These findings will be useful in developing theories to describe the etiology of MCI and the therapeutic role of anticholinesterases.
Agreements between mean arterial pressure from radial and femoral artery measurements in refractory shock patients
Authors: Wisanusattra Hemmawan , Khwannimit Bodin 
Published: October 2021

Abstract
Radial and femoral artery catheterization is the most common procedure for monitoring patients with shock. However, a disagreement in mean arterial pressure (MAP) between the two sites has been reported. Hence, the aim of this study was to compare the MAP from the radial artery (MAPradial) with that of the femoral artery (MAPfemoral) in patients with refractory shock. A prospective study was conducted in the medical intensive care unit. The radial and femoral were simultaneously measured MAP in the patients every hour, for 24 hours. In total, 706 paired data points were obtained from 32 patients. MAPradial strongly correlated with MAPfemoral (r = 0.89, p <0.0001). However, overall MAPradial was significantly lower than MAPfemoral 7.6 mmHg. The bias between MAPradial and MAPfemoral was -7.6 mmHg (95% limits of agreement (LOA), -24.1 to 8.9). In the subgroup of patients with MAPradial < 65 mmHg, MAPradial moderately correlated with MAPfemoral (r = 0.63) and the bias was increased to -13.0 mmHg (95% LOA, -28.8 to 2.9). There were 414 (58.6%) measurements in which the MAP gradient between the two sites was > 5 mmHg. In conclusion, the radial artery significantly underestimated MAP compared with the femoral artery in patients with refractory shock.
Proposing a framework for specifying the appropriateness of pursuing a career regarding Employees’ healthiness and safeguard: A Case study of food manufacturing industry
Authors: Behdinian Ayria , Rezaie Kamran , Bozorgi-Amiri Ali 
Published: October 2021

Abstract
BackgroundEmployee health is an essential issue for Human Resource Management (HRM). The employees' health level is undeniably correlated to the job position in which they work since it may harm their well-being, and they may not be capable of performing their duties properly. Prompt diagnosis and resolution of employees' physical complications are highly critical.MethodsMachine learning (ML) is the state-of-the-art method potentially utilized to make early predictions to safeguard employees' healthiness. The technical laborers within the food manufacturing company are included in this Research. The functional classification models, namely, Support Vector Machine (SVM), K-Nearest Neighbors (KNN), Logistic Regression (LR), Decision Tree, are exploited to predict the employees' wellness for their vocation. K-fold Cross-Validation (KCV) and Confusion Matrix were applied in this study, the former for estimating the model's functionality and the latter for forecasting accuracy.ResultsAfter implementing four models on the 231 employees, the accuracy was extracted out, SVM with 78%, KNN with 78%, Decision Tree with 80%, and the highest for LR algorithm with 84%.ConclusionsIn this Research, the LR algorithm was opted to paving the way for Human Resources Managers in order to utilize a functional system to predict the Suitability of factory workers concerning their healthiness. The Hearing condition was picked out as a leading factor in selecting employees for their job position. Consequently, it is significant to planning a hearing conservation program for employees, especially those exposed to excessive noise.Trial Registration: Retrospectively registered.
The Use of Autologous Skeletal Muscle Derived Cells as a Sling in the Treatment of Induced Stress Urinary Incontinence, An Experimental Study in Dogs
Authors: Wadie Bassem S , Aamer Haytham G , Khater Sherry M , Gabr Mahmoud M 
Published: October 2021

Abstract
Introduction:This is an experimental pre-clinical study, testing the applicability of autologous skeletal muscle derived cells as a treatment of SUI in canine modelMethods:10 Mongrel dogs included. Skeletal muscle biopsy was harvested in 4. 1 month later, incontinence was induced in 8 dogs through urethrolysis. Muscle biopsy was incubated and expanded for 8 weeks. Muscle derived cells were collected and covered a Polyglycolic acid (PGA) scaffold immersed in culture medium and coated with matrigel to be used as a sling. Placed suburethral in 8 dogs; 4 had cell- seeded and 4 had scaffold only. Urethral pressure (UP) measurement was done at baseline 2 &6 weeks after sling insertion. The urethra was harvested 4 weeks after sling insertion for histopathology.Results:UP shows increase of maximum urethral pressure during static measurement in all dogs with a scaffold inserted. The increase ranged from 5-40 cmH20 Histopathology shows significant periurethral proliferation of skeletal muscles in 4 dogs with cell-seeded scaffold. This was maximum in dogs # 1& 2. This was not the case in the 4 dogs that had sling only.Conclusion: Use of skeletal muscle –seeded PGA scaffold is a practical technique with preserved integrity of histological differentiation in canine model.
Anatomical Study for the Treatment of Proximal Humeral Fracture Through the Medial Approach
Authors: Xiang Hao , Wang Yan , Yang Yongliang , Liu Fanxiao , Lu Qinsen , Kong Lingpeng , Li Mingzhen , Han Yong , Wang Fu 
Published: October 2021

Abstract
Background: The treatment of complex 3- and 4- part proximal humeral fractures has been controversial due to numerous postoperative complications. With the further study of medial support and blood supply of humeral head, new techniques and conception are developing. The study aims to illustrate the medial approach of the proximal humeral fracture through cadaver autopsy.Method: Upper limbs from 19 cadavers have been dissected to expose the shoulder joint. We selected the coracoid process as the bony reference. Vernier caliper will be used to measure the following data, including distance from coracoid process to circumflex brachial artery, distance between anterior humeral circumflex artery (ACHA) and posterior circumflex brachial artery (PCHA) and their diameters. Assessment included the characteristics of the vascular supply around the humeral head, identification of the structures at risk, quality of exposure of the bony structures, and feasibility of fixation.Results: Medial plate can be easily placed in 86.84% anatomical patterns. An interval of 2 to 3cm (24.29 ± 3.42 mm) was available for internal fixation. ACHA (49.35 ± 8.13 mm, 35.14 - 68.53 mm) and PCHA (49.62 ± 7.82 mm, 37.67 - 66.76 mm) were about 5cm away from the coracoid process. Risk factors including ACHA and PCHA originate in common, PCHA originated from the deep brachial artery (DBA), the presence of perforator vessels; musculocutaneous nerve intersects with ACHA, the diameter of PCHA: ACHA < 1.5. In 13.15% anatomical patterns, this risk factor should be taken seriously. Conclusion: The medial approach opens a new perspective in the optimal management of complex fractures of proximal humerus. Anatomical research proves that the medial approach is feasible. The interval between ACHA and PCHA is suitable for placement. Anatomical pattern and indication have been discussed, and we hypothesized that ACHA has been destroyed in complex PHFs. With further studies on the anatomy and mechanism of injury, the development of more clinical cases will be an important work of our institution in the future.
Cementless Bipolar Hemiarthroplasty Compared With Proximal Femoral Nail Anti-rotation of Unstable Intertrochanteric Fractures in Senile Patients With Osteoporosis: a Retrospective Study
Authors: Cai Chengkui , Tian Liying , Chen Zhihui , Sun Pengcheng , Wang Guozhu 
Published: October 2021

Abstract
Background: Implant design for the correction of osteoporotic unstable intertrochanteric fractures in elderly patients is a controversial issue. Our study aims to compare the efficacy of PFNA and cementless bipolar hemiarthroplasty (CBH) in treating osteoporotic unstable intertrochanteric fractures in the elderly.Methods: We retrospectively assessed 52 elderly patients, aged > 70 years old, with intertrochanteric fractures (AO/OTA 31-A2 fractures) from 2014 to 2019. Among them, 24 patients received PFNA and 28 patients received CBH, accompanied with 2-year follow-ups. Additionally, the efficacy difference between the two implants was compared.Results: Both groups had similar general variables like age, gender, fracture site, degree of osteoporosis, fracture classification, ASA score, basic diseases, preoperative preparation time, anesthesia mode, along with postoperative blood transfusions and postoperative complications (P>0.05). Conversely, significant differences were observed among intraoperative variables (amount of blood loss, amount of blood transfusions, operative time, number of intraoperative fluoroscopy), postoperative variables (amount of blood loss, weight-bearing time out of bed, hospital length of stay), and Harris hip function score within 6 months of operation (P<0.05).Conclusions: CBH showed no obvious advantage over PFNA in the perioperative period in elderly patients with osteoporotic unstable intertrochanteric fractures. However, the joint replacement allowed for earlier ambulation after the operation and rapid recovery of the hip joint function.
E3 Ubiquitin Ligase NEDD4L Negatively Regulates Breast Cancer Metastasis By Downregulating SNAI2
Authors: Zuo Baile , Lan Ying , Li Xiaoyan , Zhao Liping , Yu Kexin , Tong Binghua , Guo Zhenni , Sun Meiqing , Zhao Jin , Zhang Huina , Zhang Huahao , Li Guoyin 
Published: October 2021

Abstract
Background

Accumulating evidence demonstrated that the abnormal expression of E3-ubiquitin ligase NEDD4L plays an important role in the biological process of carcinomas. However, its role in breast cancer (BRCA) remains elusive.
Methods

The expression of NEDD4L was analyzed using BRCA datasets from public database. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used for enrichment analysis. Both transwell assay and pulmonary metastasis model of BRCA were used to detect metastatic ability of cells. Western blotting, immunohistochemistry and immunofluorescence assay were used to detect the protein expression of target genes. The riskScore and nomogram were used to evaluate the prognosis of patients.
Results

NEDD4L was significantly downregulated in cancer tissues and positively correlated with the overall survival of patients. Knocking down NEDD4L could enhance the migration and metastasis ability of BRCA cells. SP1 promotes NEDD4L expression, resulting in SNAI2 downregulation in BRCA. A NEDD4L related to the prognostic model developed by LASSO Cox regression could be an independent predictive factor for BRCA. A nomogram combining riskScore and clinical indicators was established to evaluate the prognosis of BRCA quantitatively.
Conclusions

This study first reveals the role of the SP1/NEDD4L/SNAI2 axis in BRCA and establishes a reliable prognostic model, which provides a novel target and basis for clinical treatment and prognosis evaluation of breast cancer.