bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRMT1-mediated EZH2 methylation promotes breast cancer cell proliferation and tumorigenesis
Authors: Li Zhongwei , Wang Diandian , Chen Xintian , Wang Wenwen , Wang Pengfei , Hou Pingfu , Li Minle , Chu Sufang , Qiao Shuxi , Zheng Junnian , Bai Jin 
Published: November 2021

AbstractProtein arginine methyltransferase 1 (PRMT1) is able to promote breast cancer cell proliferation. However, the detailed mechanisms of PRMT1-mediated breast cancer cell proliferation are largely unknown. In this study, we reveal that PRMT1-mediated methylation of EZH2 at the R342 site (meR342-EZH2) has a great effect on PRMT1-induced cell proliferation. We also demonstrate that meR342-EZH2 can accelerate breast cancer cell proliferation in vitro and in vivo. Further, we show that meR342-EZH2 promotes cell cycle progression by repressing P16 and P21 transcription expression. In terms of mechanism, we illustrate that meR342-EZH2 facilitates EZH2 binding with SUZ12 and PRC2 assembly by preventing AMPKα1-mediated phosphorylation of pT311-EZH2, which results in suppression of P16 and P21 transcription by enhancing EZH2 expression and H3K27me3 enrichment at P16 and P21 promoters. Finally, we validate that the expression of PRMT1 and meR342-EZH2 is negatively correlated with pT311-EZH2 expression. Our findings suggest that meR342-EZH2 may become a novel therapeutic target for the treatment of breast cancer.
The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells
Authors: Park Soeun , Kim Yoon-Jae , Park Jung Min , Park Minsu , Nam Kee Dal , Farrand Lee , Nguyen Cong-Truong , La Minh Thanh , Ann Jihyae , Lee Jeewoo , Kim Ji Young , Seo Jae Hong 
Published: November 2021

AbstractN-terminal HSP90 inhibitors in development have had issues arising from heat shock response (HSR) induction and off-target effects. We sought to investigate the capacity of NCT-58, a rationally-synthesized C-terminal HSP90 inhibitor, to kill trastuzumab-resistant HER2-positive breast cancer stem-like cells. NCT-58 does not induce the HSR due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills the rapidly proliferating bulk tumor cells as well as the breast cancer stem-like population, coinciding with significant reductions in stem/progenitor markers and pluripotent transcription factors. NCT-58 treatment suppressed growth and angiogenesis in a trastuzumab-resistant xenograft model, concomitant with downregulation of ICD-HER2 and HSF-1/HSP70/HSP90. These findings warrant further investigation of NCT-58 to address trastuzumab resistance in heterogeneous HER2-positive cancers.
TRAF7 contributes to tumor progression by promoting ubiquitin-proteasome mediated degradation of P53 in hepatocellular carcinoma
Authors: Zhang Qi , Zhang Xinqi , Dong Weiguo 
Published: November 2021

AbstractIt has been proved that TRAFs family proteins played malfunctioning roles in the development of human cancers. TRAF7 is the last one of TRAFs family proteins to be found, which was demonstrated to be involved in a serious of cancers development. In this study, we systematically investigated the molecular mechanisms of TRAF7 in facilitating hepatocellular carcinoma (HCC). We discovered that TRAF7 was overexpressed in tumor tissues and the increased TRAF7 expression was closely associated with tumor size, histologic grade, TNM stage and poor prognostication. TRAF7 overexpression repressed cell apoptosis and promoted cell proliferation, invasion and migration, whereas knockdown of TRAF7 in HCC cells had totally opposite effects. Besides, we identified the interaction between TRAF7 and P53 in HCC and demonstrated that TRAF7 promoted ubiquitin-proteasome mediated degradation of P53 at K48 site. The rescue assays further proved that the function of TRAF7 in inhibiting apoptosis and promoting tumor development was depended on P53 in HCC. Overall, this work identified that TARF7 promoted tumorigenesis by targeted degradation P53 for ubiquitin-mediated proteasome pathway. Targeting the TRAF7-P53 axis may provide new insights in the pathogenesis of HCC, and pave the way for developing novel strategies for HCC prevention and treatment.
Sulfate adenylyl transferase kinetics and mechanisms of metabolic inhibitors of microbial sulfate respiration
Authors: Carlson Hans K , Youngblut Matthew D , Redford Steven A , Williamson Adam J , Coates John D 
Published: November 2021

AbstractSulfate analog oxyanions that function as selective metabolic inhibitors of dissimilatory sulfate reducing microorganisms (SRM) are widely used in ecological studies and industrial applications. As such, it is important to understand the mode of action and mechanisms of tolerance or adaptation to these compounds. Different oxyanions vary widely in their inhibitory potency and mechanism of inhibition, but current evidence suggests that the sulfate adenylyl transferase/ATP sulfurylase (Sat) enzyme is an important target. We heterologously expressed and purified the Sat from the model SRM, Desulfovibrio alaskensis G20. With this enzyme we determined the turnover kinetics (kcat, KM) for alternative substrates (molybdate, selenate, arsenate, monofluorophosphate, and chromate) and inhibition constants (KI) for competitive inhibitors (perchlorate, chlorate, and nitrate). These measurements enable the first quantitative comparisons of these compounds as substrates or inhibitors of a purified Sat from a respiratory sulfate reducer. We compare predicted half-maximal inhibitory concentrations (IC50) based on Sat kinetics with measured IC50 values against D. alaskensis G20 growth and discuss our results in light of known mechanisms of sensitivity or resistance to oxyanions. This analysis helps with the interpretation of recent adaptive laboratory evolution studies and illustrates the value of interpreting gene–microbe–environment interactions through the lens of enzyme kinetics.
Pollution morphology characteristics on a superhydrophobic surface and its pollution flashover voltage in DC electric field
Authors: Liu Yijie , Guo Yujun , Wang Bo , Zhang Xueqin , Huang Guizao , Zhang Guangquan , Liu Yicen , Deng Qin , Wu Guangning 
Published: November 2021

AbstractTo solve the pollution problem of insulators on ultra‐high voltage DC transmission lines, superhydrophobic coatings were presented and their pollution deposit morphology and pollution flashover voltage in electric field were studied by an artificial pollution deposit system. The experimental results show that the pollution on the surface of superhydrophobic coating is distributed in clusters, which inhibits the chain distribution on the surface of silicone rubber and improves the pollution flashover voltage. Secondly, the competition mechanism of the pollution flashover on the superhydrophobic coating surface was found. This competition mechanism can lead to the failure of the insulation performance of the superhydrophobic coating in severely polluted environments. Finally, a pollution flashover model of superhydrophobic coating is proposed to explain the competition mechanism, which is affected by pollution and the discrete droplets. The conclusions of this study can provide an experimental and theoretical basis for the application of the superhydrophobic coating in the field of UHV DC external insulation.
A multistage distribution network planning method considering distributed generation active management and demand response
Authors: Koutsoukis Nikolaos C. , Georgilakis Pavlos S. 
Published: November 2021

AbstractThis paper proposes a multistage distribution network planning (DNP) method that considers multiple planning alternatives, the active management of distributed generation (DG) units and demand response in the context of active distribution networks (ADNs). Representative days are selected for the consideration of uncertainties related with load demand and renewable power generation, during the planning period. The proposed DNP method aims at minimising the net present value of the total investment and operational cost. The proposed DNP considers multiple planning alternatives, such as the reinforcement of existing substations and existing distribution lines, the installation of new distribution lines, and the installation of capacitors. Furthermore, the proposed DNP method incorporates the control capabilities of DG active and reactive power output and demand response schemes. A 24‐bus distribution network and a 144‐bus real world distribution network are used to validate the performance of the proposed method.
Coordinated control to achieve stability and dynamic response enhancement of weak‐grid‐connected inverters based on sequence‐admittance models
Authors: Yu Yanxue , Zheng Xuemei , Li Haoyu , Guerrero Josep M. , Akhavan Ali 
Published: November 2021

AbstractIn grid‐connected inverters (GCIs), the phase‐locked loop (PLL) behaves as a negative admittance at the point of common coupling (PCC), composed of both the PLL controller and current controller terms. Therefore, not only the PLL dynamics, but also dynamical interactions between the PLL controller and current controller might trigger instabilities in weak grids, which complicates the controller parameters regulation. The smaller PLL bandwidth could help to mitigate the instabilities, but at the expense of sacrificing the system dynamic response. In view of this, a coordinated control composed of the q‐axis voltage and PCC‐voltage feedforward based on sequence‐admittance models is proposed here. The q‐axis voltage feedforward is designed with a simple proportional feedforward coefficient to make the PLL‐induced negative admittance insensitive to the PLL controller parameters. In other words, the PLL bandwidth would not be limited by the stability requirements and the dynamic response speed could be ensured. Furthermore, the PCC‐voltage feedforward is developed to coordinate the q‐axis voltage feedforward by phase compensation, thus to achieve stability improvement. Finally, simulations and hardware‐in‐the‐loop tests are carried out to verify the enhanced stability and dynamic response of the modified GCI with the proposed coordinated control in weak grid.
A cold accretion flow onto one component of a multiple protostellar system
Authors: Murillo N. M. , van Dishoeck E. F. , Hacar A. , Harsono D. , Jørgensen J. K. 
Published: November 2021

Context. Gas accretion flows transport material from the cloud core onto the protostar. In multiple protostellar systems, it is not clear if the delivery mechanism is preferential or more evenly distributed among the components.
Aims. The distribution of gas accretion flows within the cloud core of the deeply embedded, chemically rich, low-mass multiple protostellar system IRAS 16293−2422 is explored out to 6000 AU.
Methods. Atacama Large Millimeter/submillimeter Array Band 3 observations of low-J transitions of various molecules, such as HNC, cyanopolyynes (HC3N, HC5N), and N2H+, are used to probe the cloud core structure of IRAS 16293−2422 at ~100 AU resolution. Additional Band 3 archival data provide low-J HCN and SiO lines. These data are compared with the corresponding higher-J lines from the PILS Band 7 data for excitation analysis. The HNC/HCN ratio is used as a temperature tracer.
Results. The low-J transitions of HC3N, HC5N, HNC, and N2H+ trace extended and elongated structures from 6000 AU down to ~100 AU, without any accompanying dust continuum emission. Two structures are identified: one traces a flow that is likely accreting toward the most luminous component of the IRAS 16293−2422 A system. Temperatures inferred from the HCN/HNC ratio suggest that the gas in this flow is cold, between 10 and 30 K. The other structure is part of an uv-irradiated cavity wall entrained by one of the outflows driven by the source. The two outflows driven by IRAS 16293−2422 A present different molecular gas distributions.
Conclusions. Accretion of cold gas is seen from 6000 AU scales onto IRAS 16293−2422 A but not onto source B, indicating that cloud core material accretion is competitive due to feedback onto a dominant component in an embedded multiple protostellar system. The preferential delivery of material could explain the higher luminosity and multiplicity of source A compared to source B. The results of this work demonstrate that several different molecular species, and multiple transitions of each species, are needed to confirm and characterize accretion flows in protostellar cloud cores.
Reactions of Sulfoxides with Benzynes
Authors: Shi Jiarong , Li Yang , Wan Caiwen 
Published: November 2021

AbstractSulfoxides are important organic synthons that have been used in a variety of transformations. In this account, we focus on advances in the reaction of sulfoxides with benzynes, which can be divided into two types: benzyne ortho-difunctionalization and benzyne multifunctionalization.1	Introduction2	Benzyne ortho-Difunctionalization3	Benzyne Multifunctionalization4	Conclusion
Catalytic Deoxygenative Cyclopropanation of 1,2-Dicarbonyl or Monocarbonyl Compounds via Molybdenum Catalysis
Authors: Zhuo Chun-Xiang , Wang Jia-Le 
Published: November 2021

AbstractThe cyclopropanation of alkenes through the transition-metal-catalyzed decomposition of diazo compounds is a powerful and straightforward strategy to produce cyclopropanes. Nevertheless, the appeal of further application of this strategy is tempered by the potentially explosive nature of the diazo substrates. Therefore, it is highly desirable to develop sustainable and operationally safe surrogates for diazo compounds. In this Synpacts article, we discuss recent advances on the cyclopropane syntheses through the catalytic cyclopropanation of alkenes and metal carbenes generated in situ from nondiazo precursors as well as highlight our recent progress on the unprecedented molybdenum-catalyzed deoxygenative cyclopropanation reaction of 1,2-dicarbonyl or monocarbonyl compounds.
A Rare Presentation of Osteoid Osteoma in a 77-Year-Old Patient, Treated with Computer Tomography–Guided Percutaneous Radiofrequency Ablation
Authors: Patel Anish , Davies Mark , James Steven , Azzopardi Christine , Botchu Rajesh 
Published: November 2021

AbstractOsteoid osteoma (OO) is a benign bone forming tumor characterized by small size and a disproportionate amount of pain. They are most commonly seen between the ages of 5 and 30 years; however, they can be seen in the older patient albeit infrequently. The hands and feet are the least common site of OO among the extremity bones. We present a case of an OO in the hand of a 77-year-old man who underwent successful treatment with computed tomography–guided percutaneous radiofrequency ablation. We believe this is the oldest recorded patient in the medical literature with a histologically confirmed OO. The condition should therefore be considered in the differential diagnosis of a painful sclerotic bone lesion in this age group to avoid a delay in diagnosis and subsequent treatment.
Scrotal Lipoblastoma with Radiological and Histological Correlation
Authors: Rousslang Lee K. , Burr Cole R. , Wood Jonathan R. 
Published: November 2021

AbstractLipoblastomas are rare benign mesenchymal tumors comprised primarily mature adipocytes, which are most commonly found in infants and children younger than 3 years. They are usually found in the extremities, trunk, head, neck, and retroperitoneum, although cases occurring in the scrotum have been reported. Due to its rarity, there is a relative paucity of literature describing its imaging and management. We present a rare case of a scrotal lipoblastoma, and discuss the current imaging strategies to differentiate this adipocytic tumor from other more common paratesticular masses, including aggressive neoplasms such as rhabdomyosarcomas. Knowledge of the radiological appearance of lipoblastoma can provide the correct diagnosis and prevent unnecessary orchiectomy.
Labrune Syndrome: A Very Rare Association of Leukoencephalopathy, Cerebral Calcifications, and Cysts
Authors: Joshi Anagha R. , Kulkarni Kiran , Shah Ankita U. 
Published: November 2021

AbstractLeukoencephalopathy, cerebral calcifications, and cysts (LCC) form a very rare association which is named as “Labrune syndrome” after Labrune who reported the first case in 1996. To the best of our knowledge only eight to 10 cases have been reported in literature to date. We report a case of a 26-year-old male with onset of neurological symptoms in late adolescence (at 19 years of age) and presented with complains of continued seizures for 7 years, giddiness with imbalance, and slowly progressive motor symptoms. MRI brain revealed multiple calcifications in bilateral basal ganglia, cerebral white matter, multiple cystic lesions in the supratentorial white matter, and abnormal diffused bilateral white matter T2 hyperintensity suggesting leukoencephalopathy. Histopathological evaluation revealed prominent congested blood vessels suggestive of angiomatous changes and cystic areas suggestive of secondary gliosis.
Accuracy of Magnetic Resonance Parkinsonism Index in Differentiating Progressive Supranuclear Palsy from Parkinson's Disease among South Indian Population: A Retrospective Case Control Study
Authors: Janarthanan Vasanthapriya , Nadhamuni Kulasekaran , Rajakumar Sibhithran , Padmanaban Elamparidhi , Amirthalingam Umamageswari , Achantani Yashkumar 
Published: November 2021

Abstract
Context Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which comes under Parkinsonism plus syndrome. As this spectrum of disease has many overlapping clinical as well as imaging findings, some quantitative parameters like magnetic resonance Parkinsonism index and midbrain/pons ratio are useful to differentiate PSP from other PD patients.
Aims The study aimed to detect sensitivity and specificity of magnetic resonance Parkinsonism index in differentiating PSP from PD.
Settings and Design It was a retrospective case–control study conducted in Sri Manankula Vinayagar Medical College, Puducherry, during the period of January 2018 to June 2019.
Materials and Methods The 87 subjects, who were diagnosed and grouped into three categories (PSP, PD, and control) after performing magnetic resonance imaging brain, were reviewed. The parameters like the area of Pons and midbrain, width of MCP and SCP, P/M, M/P, and MRPI were calculated.
Statistical Analysis One-way ANOVA and Chi-square test was used. The sensitivity, specificity, diagnostic accuracy, and cut-off values obtained with receiver operating characteristic curve analysis were determined.
Results The mean age of presentation was approximately 75 years with male predominance. The cut-off value of MRPI obtained in this study was 13.4 with 100% sensitivity and specificity. Even though M/P ratio was found to be statistically significant among PSP patients; cut-off value was not obtained.
Conclusion MRPI was concluded as the better tool in diagnosing PSP compared with the M/P ratio. Hence the combined qualitative as well as quantitative measurement of MRPI will increase the diagnostic accuracy of PSP.
2021 Focused Update Consensus Guidelines of the Asia Pacific Heart Rhythm Society on Stroke Prevention in Atrial Fibrillation: Executive Summary
Authors: Chao Tze-Fan , Joung Boyoung , Takahashi Yoshihide , Lim Toon Wei , Choi Eue-Keun , Chan Yi-Hsin , Guo Yutao , Sriratanasathavorn Charn , Oh Seil , Okumura Ken , Lip Gregory Y. H. 
Published: November 2021

AbstractThe consensus of the Asia Pacific Heart Rhythm Society (APHRS) on stroke prevention in atrial fibrillation (AF) has been published in 2017 which provided useful clinical guidance for cardiologists, neurologists, geriatricians, and general practitioners in the Asia-Pacific region. In these years, many important new data regarding stroke prevention in AF were reported. The practice guidelines subcommittee members comprehensively reviewed updated information on stroke prevention in AF, and summarized them in this 2021 focused update of the 2017 consensus guidelines of the APHRS on stroke prevention in AF. We highlighted and focused on several issues, including the importance of the AF Better Care pathway, the advantages of non-vitamin K antagonist oral anticoagulants (NOACs) for Asians, the considerations of use of NOACs for Asian AF patients with single one stroke risk factor beyond gender, the role of lifestyle factors on stroke risk, the use of oral anticoagulants during the “coronavirus disease 2019” pandemic, etc. We fully realize that there are gaps, unaddressed questions, and many areas of uncertainty and debate in the current knowledge of AF, and the physician's decision remains the most important factor in the management of AF.
Modelling and simulation of soft robotic human tongue with improved motion
Authors: Rodriguez Selena , Galvan Ruri , Ganta Deepak 
Published: November 2021

Abstract
There is a huge demand for electronic tongues in the food and pharmaceutical industries for chemical detection and flavor analysis. The lack of availability of robots with electronic tongues has motivated us to investigate, design, and simulate a human tongue’s complex motions. Human anatomy was studied in detail to modify the standard design of the human tongue, with the addition of 32 embedded chambers at strategic locations, to replicate various 3D motions (rolling, groove, twist, and elongation) of the human tongue necessary for improving the biochemical sensing capabilities. The FEM (Finite element method) simulations showed the relation between pressure and deformation range for various kinds of motions in a human tongue, including the mechanical properties from the stress versus strain response.
Ambivalent: Photography and Visibility in African History
Authors: Tucker Jennifer , Fox-Amato Matthew , Gürsel Zeynep Devrim , Kothor Marius , Ramaswamy Sumathi , Shevchenko Olga 
Published: November 2021

Abstract
In this roundtable, five historians come together to review the collected essays in Ambivalent: Photography and Visibility in African History. Jennifer Tucker provides an overview of the content of the book and its significance in terms of scholarship on photography and African history. Matthew Fox-Amato studies how powerful photographs can be as evidence when combined with other kinds of sources such as oral narratives. Referring to the essays of Patricia Hayes and Isabelle de Rezende, Marius Kothor notes how the intersection between photography and oral tradition create new ways of conceptualizing the relation between photography and time. Olga Shevchenko marvels at the ability of photography to open up discussions regarding colonial and postcolonial relationships of power, knowledge production, ethnic and political pluralism, and subjectivity that transcend the frame. Writing about the essay of Phindi Mnyaka, Zeynep Devrim Gürsel observes how we forge different perspectives from the same photograph and, in the process, unravel new analytical spaces. Finally, Sumathi Ramaswamy references the essays of Ingrid Masondo and Gary Minkley to draw attention to the use of photography as a surveillance instrument by oppressive regimes.