bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of 5-Aminosalicylic Acid on Ustekinumab in Inflammatory Bowel Disease: A Retrospective Medical Claims Analysis
Authors: Nishida Yu , Hosomi Shuhei , Fujimoto Koji , Kobayashi Yumie , Nakata Rieko , Maruyama Hirotsugu , Ominami Masaki , Nadatani Yuji , Fukunaga Shusei , Otani Koji , Tanaka Fumio , Fujiwara Yasuhiro 
Published: January 2025

Abstract

Background
The efficacy of 5-aminosalicylic acid (5-ASA) in combination with advanced therapies (ADTs), particularly ustekinumab (UST), for the treatment of inflammatory bowel disease (IBD) remains unclear.

Methods
This retrospective cohort analysis used data from the Medical Data Vision database, including patients with ulcerative colitis (UC) and Crohn’s disease (CD) who had initiated UST therapy. Cumulative UST continuation rates and factors associated with UST failure were analyzed, and post hoc subgroup analyses based on prior ADT use were conducted.

Results
A total of 1971 patients with CD and 1284 patients with UC were included. Overall, the concomitant use of 5-ASA did not significantly affect UST failure in either CD or UC. Post hoc subgroup analysis suggested a protective effect of 5-ASA in ADT-naïve patients with CD or UC who had been previously exposed to ADT.

Conclusions
5-ASA did not provide a significant overall benefit when used in combination with UST for CD or UC. However, post hoc subgroup analyses indicated a potential role for 5-ASA in specific subgroups. Further studies are necessary to confirm these findings and explore personalized treatment strategies.
Payment Matters: Understanding Payer Perspectives on Laboratory Stewardship
Authors: Astion Michael L , Baird Geoffrey S 
Published: January 2025

Abstract

Background
The US healthcare system is complex and includes a number of entities and systems that provide services to patients and to pay for them. While improving health and well-being are accepted goals of healthcare, the 3 stakeholder groups relevant to healthcare—patients, providers, and payers—often have different perspectives on how care should be utilized, performed, and paid for. These differing perspectives are discussed as they relate to clinical laboratory testing.

Content
Patients expect that the laboratory tests performed on them are necessary and covered by their insurance. Providers expect that they will be able to carry out what they believe to be the standard of care for their patients, and they furthermore expect that the systems in place from laboratories and payers will support their efforts without exposing their patients or their practice to financial toxicity. Payers, finally, desire to meet the needs of their customers, who are both patients as well as employers, by providing access to necessary healthcare services at a fair cost. Aligning these desires and perspectives is challenging in a fragmented healthcare system, and in the face of substantial opportunities for secondary gain from disreputable practices such as fraud, waste, and abuse.

Summary
Within the constraints of a US healthcare system based on competition and susceptible to misalignment, opportunities nonetheless exist for all relevant stakeholders in the laboratory testing space (patients, providers, and payers) to align and agree on practices that provide reasonably priced, fairly distributed, and medically necessary healthcare.
A long noncoding RNA with enhancer-like function in pig zygotic genome activation
Authors: Wei Renyue , Yue Yanbin , Wu Yinhuan , Zhang Chenyuan , Jin Junxue , Liu Zhonghua , Wang Jiaqiang 
Published: January 2025

Abstract
The zygotic genome activation (ZGA) is crucial for the development of pre-implantation embryos. Long noncoding RNAs (lncRNAs) play significant roles in many biological processes, but the study on their role in the early embryonic development of pigs is limited. In this study, we identify lncFKBPL as an enhancer-type lncRNA essential for pig embryo development. LncFKBPL is expressed from the 4-cell stage to the morula stage in pig embryos, and interference with lncFKBPL leads to a developmental arrest at the 8-cell stage. Mechanistic investigations uncover that lncFKBPL is able to bind to MED8, thereby mediating enhancer activity and regulating FKBPL expression. Additionally, FKBPL interacts with the molecular chaperone protein HSP90AA1, stabilizing CDK9 and boosting its protein-level expression. Elevated CDK9 levels enhance Pol II phosphorylation, facilitating ZGA. Our findings illuminate the role of lncFKBPL as an enhancer lncRNA in pig ZGA regulation and early embryo development, providing a foundation for further exploration in this area.
Building absolute breast cancer risk prediction models for women treated with chest radiation for Hodgkin lymphoma
Authors: Roberti Sander , van Leeuwen Flora E , Hauptmann Michael , Pfeiffer Ruth M 
Published: January 2025

Abstract
We built models to predict absolute breast cancer (BC) risk in women treated with radiotherapy for Hodgkin lymphoma (HL). We first estimated relative risks (RRs) for risk factors, including radiation dose to 10 breast segments to accommodate heterogeneity of treatment effects, using a case-control sample nested in an HL survivor cohort. To estimate RRs of case-control matching factors we developed novel weighting approaches. We then combined RRs with age-specific BC incidence and competing mortality rates from the HL survivor cohort and a population-based registry, accommodating differences between them. We compared the performance of models using segment-specific doses with using mean dose only.
Failing Asylum-Seekers: Limited Judicial Review of Refugee Status Determination Decisions in Brazil
Authors: Ferolla Vallandro do Valle Mariana 
Published: January 2025

Abstract
This article seeks to show how Brazilian courts’ unwillingness to perform judicial review over the merits of administrative refugee status determination (RSD) decisions is both founded on unfounded premises and incompatible with Brazil’s obligations under international law. To that effect, the article promotes an analysis of the case law issued by Brazilian appellate courts on this issue until April 2024. These courts have overwhelmingly held that RSD decisions are political acts over which the executive branch of government holds absolute discretion and are thus excluded from judicial review. Nevertheless, this reasoning is based on misconceptions about the normative refugee protection framework and is inconsistent with the declaratory nature of refugee status. Lack of a review of the merits of RSD decisions also goes against the right to judicial protection under Article 25 of the American Convention on Human Rights, ultimately voiding the right to asylum in its Article 22(7) for many asylum-seekers. This article finds that Brazilian courts’ erroneous conclusions about the nature of RSD decisions compromise effective refugee protection in the country, essentially subsuming this protection into a policy choice.
Explaining political turnarounds on minimum wages: the Italian case in a comparative perspective
Authors: Meardi Guglielmo , Seghezzi Francesco 
Published: January 2025

Abstract
While the majority of OECD countries have a national minimum wage, a minority relies on collective bargaining as a functionally equivalent alternative model. Some countries have recently changed model or started discussing it. We ask when and why advanced capitalist democracies make such change, testing functionalist, power resource and institutional explanations. The article looks at the cases of UK and Germany (which introduced a national minimum wage) and Italy (which have started discussing it), against the background of Sweden, which, like other countries, refuse to do so. In doing so, we identify some conditions and contributing factors that allow to better understand how institutional legacies affect shifts in regulatory approaches to wage setting, and draw some implications for labour market policies, especially in the particularly open Italian case.
Serial evaluation of local changes in snakebite envenomation using infrared thermal imaging
Authors: Sabitha Paramasivam , Ramadoss Ramu , Bammigatti Chanaveerappa , Kadhiravan Tamilarasu 
Published: January 2025

Abstract

Background
There is a lack of objective tools to assess the local changes following snakebite envenomation. We aimed to describe the progression of local changes in envenomed patients using serial infrared thermal imaging.

Methods
In a prospective sample of patients with snakebite envenomation, clinical assessment and infrared imaging of local changes were done at enrolment and 6 h and 24 h later, followed by once daily until hospital discharge or day 7, whichever was earlier. Infrared images were interpreted by an investigator masked to clinical findings.

Results
We studied 39 patients with snakebite envenomation. Their mean age was 44.6±12.7 y and 25 (64%) were men. The median time to stability of local changes was 24.6 h (interquartile range [IQR] 17.0–30.1) on clinical examination and 28.0 h (IQR 13.7–55.2) on infrared imaging. At 24 h there was simple agreement between the two methods on whether the local changes were progressing or not in 31 of 39 patients (80%; Cohen's κ=0.59, p&lt;0.001). The maximum proximal extent of local changes assessed using the two methods had a good correlation (Spearman's ρ=0.713, p&lt;0.001). However, the extent of thermal changes on infrared images often exceeded the upper limit of swelling detected clinically.

Conclusions
Infrared imaging could be used to objectively document the local changes caused by snakebite envenomation.
Profile of snakebite cases admitted to the Poison Control Center of Bach Mai Hospital in northern Vietnam from 2008 to 2020
Authors: Le Thuan Q , Le Linh T H , Nguyen Hoang H , Ha Hung T , Nguyen Nguyen T , Nguyen Truong Q , Ziegler Thomas , Do Tung T , Nguyen Tao T 
Published: January 2025

Abstract

Background
Vietnam harbours a high species richness of venomous snakes with &gt;60 recognised species but snakebite pathology and treatment are still understudied, particularly in northern Vietnam.

Methods
A retrospective study from 2008 to 2020 was conducted, focusing on snakebite cases at the Poison Control Center of Bach Mai Hospital, a major centre in northern Vietnam for treating envenoming incidents.

Results
A total of 5805 snakebite cases were reported over 12 y. The demography of patients was predominantly male snakebite victims (70%), middle-aged (30–59 y) and mostly from rural districts. Cobra (Naja spp.) attacks were the main culprit, accounting for 39% of cases, and most snakebites occurred in the rainy season. The majority of patients were from Hanoi, but the percentage of cases from other provinces increased over the years up to 75% in 2020. The highest number of snakebites were recorded from communes with snake farms.

Conclusions
Male gender, rainy season, rural residency and snake farming were identified as major risk factors for contracting snakebites. Multicentre hospital studies, cross-sectional community surveys and a central snakebite database are needed to better understand and deal with snakebites in Vietnam.
Listings of Buprenorphine Offering by Substance Use Disorder Treatment Facilities and Waivered Clinician From July 2019 to May 2021
Authors: Ali Mir M. , Taylor Erin A. , Stein Bradley D. , Mizushima Yuji , Agniel Denis , Cantor Jonathan 
Published: January 2025

Objectives
This study explores trends in buprenorphine availability at substance use disorder treatment facilities (SUDTFs) and by waivered clinicians during the pandemic. We also examined whether there were differences in access based on a county's metropolitan status and annual fatal drug poisoning rate.

Methods
Data from the Substance Abuse and Mental Health Services Administration' Behavioral Health Treatment Locator between July 2019 and May 2021 were used to calculate trends in SUDTFs offering buprenorphine and the number of waivered clinicians per 10,000 population. We calculated unadjusted trends over time, stratified by whether a county was above or below the annual median age-adjusted fatal drug overdose rate in that year and the county's metropolitan status.

Results
Results showed an increase in SUDTFs and waivered clinicians offering buprenorphine before the pandemic, but the rate leveled off during the pandemic. On average, the increase in facilities was about 8 percentage points per year, and the increase in waivered clinicians was 0.29 per year. The percentage of SUDTFs offering buprenorphine peaked at 47%, and the number of waivered clinicians leveled off at 1.61 per 10,000 population.
There were more SUDTFs and clinicians offering buprenorphine in metropolitan versus nonmetropolitan counties. There were also more SUDTFs and clinicians offering buprenorphine in counties above versus below median poisoning rates.

Conclusions
This study provides insights into how buprenorphine availability changed during the COVID-19 pandemic and before the removal of the X-waiver in 2023. More outreach will be needed to encourage the offering of buprenorphine by SUDTFs and office-based clinicians.
Reducing Cerebrospinal Fluid Sampling Frequency and Costs in Patients With Ventriculostomy for Aneurysmal Subarachnoid Hemorrhage: A Quality Improvement Initiative
Authors: Lin Victor , Levitt Michael R. , Zunt Joseph , Lele Abhijit V. 
Published: January 2025

Background:
We implemented a quality improvement project to transition from routine cerebrospinal fluid (CSF) sampling to indication-based sampling in aneurysmal subarachnoid hemorrhage (aSAH) patients with an external ventricular drain (EVD).

Methods:
Forty-seven patients were assessed across 2 epochs: routine (n=22) and indication-based (n=25) CSF sampling. The primary outcome was the number of CSF samples, and secondary outcomes included cost reductions and ventriculostomy-associated infections.

Results:
Patient characteristics were similar in the routine and indication-based sampling groups, as was the mean (SD) EVD duration (13.86 [5.28] days vs. 12.44 [4.78] days, respectively; P=0.936). One hundred eight CSF samples were collected during the quality improvement project; 81 in the routine sampling period and 27 in the indication-based sampling period. The median (interquartile range) CSF sampling rate reduced from 4 (3 to 4) per patient during routine sampling to 1 (0 to 2) during indication-based sampling (odds ratio: 0.19; 95% CI: 0.08-0.46; P<0.001), representing a 73% reduction in the number of samples after the transition to indication-based sampling. Each CSF sample cost $723, resulting in total sampling costs in the routine and indication-based sampling periods of $58,571 and $19,524, respectively. Therefore, the mean cost per patient was significantly higher in the routine sampling period than in the indication-based period ($2772 [$615] vs. $889 [$165], respectively; P=0.007). There were no ventriculostomy-associated infections in either period.

Conclusion:
Transitioning from routine to indication-based CSF sampling in aSAH patients with an EVD reduced sampling frequency and associated costs without increasing infection rates.
Enhancing Recovery in Severe Adolescent Idiopathic Scoliosis (AIS) Patients With Cobb Angle ≥90 Degrees Undergoing Single-staged Posterior Spinal Fusion (PSF)
Authors: Chandirasegaran Saturveithan , Chan Chris Yin Wei , Chiu Chee Kidd , Mohamad Siti Mariam , Hasan Mohd Shahnaz , Kwan Mun Keong 
Published: January 2025

Study design:
Retrospective study.

Objective:
To assess the feasibility and outcome of rapid recovery protocol (RRP) in severe adolescent idiopathic scoliosis (AIS) patients with Cobb angle ≥90 degrees underwent single-staged posterior spinal fusion (PSF).

Summary of background data:
Corrective surgeries in severe AIS patients entail a higher risk of prolonged operation, excessive bleeding, extended hospital stay, and higher complication rates compared with non-severe AIS patients. Implementation of RRP among severe AIS patients has not been reported.

Methods:
Thirty-seven severe AIS patients who underwent single-staged PSF surgery from 2019 to 2022 were recruited. The RRP consisted of a preoperative regime and counselling, intraoperative strategies to reduce operation duration and blood loss and an accelerated postoperative rehabilitation pathway. Outcome measures were operative time, blood loss, postoperative pain scores, patient-controlled analgesia (PCA) morphine usage, length of hospital stay, and recovery milestones. Descriptive statistics were reported in mean (SD) for numerical data, whereas categorical data were presented in n (%).

Results:
The mean operation duration was 173.5±39.4 minutes, and the mean blood loss was 1064.6±473.3 mL. The average postoperative hospital stay was 3.2±0.6 days. Twelve hours post-operation pain score was 4.0±2.0 and reduced to 3.9±1.6 at 48 hours. 78.4% of patients discontinued their PCA at 48 hours. First liquid intake was at 6.3±8.5 hours, whereas solid food consumption was initiated at 23.4±14.2 hours. The urinary catheter was removed at 17.8±7.6 hours. Patients started ambulation at 24±12.7 hours, first passed flatus at 37.7±20.4 hours and had their first bowel movement at 122.1±41.7 hours. Three complications (8.1%) were reported, which included superficial surgical site infection, proximal wound stitch abscess and superficial thermal injury due to forced air-warming blanket.

Conclusion:
The implementation of the RRP after PSF in severe AIS patients was feasible and resulted in a short postoperative hospital stay of 3.2 days without increasing the risk of major complications, readmissions, and reoperations.
Risk of Blindness From Temple Filler Injections: Investigating Vascular Anastomoses Between the Deep Temporal and Ophthalmic Arteries
Authors: Sheth Nishita T. , Hauck Erik F. , Bibawy Joseph M. , Lee Irene T. , Dermarkarian Christopher R. , Saadat David , Woodward Julie A. 
Published: January 2025

Purpose:
Soft-tissue filler injections, particularly hyaluronic acid, are popular for temple volume restoration. Although uncommon, this area poses risk for vision loss from embolic occlusion. Guidelines recommend injecting into the supraperiosteal plane for safety; however, the deep temporal arteries (DTAs) in this plane pose a risk. This study investigates potential pathways from the DTA to the ophthalmic artery (OA) and mechanisms of filler travel.

Methods:
Retrospective analysis of carotid angiograms from patients with marked carotid artery stenosis or vascular malformations, given that collaterals are more visible in the presence of vascular blockages. Select cases were identified by the neurosurgery team.

Results:
Four anastomotic pathways between the DTA and OA were identified, displaying a combination of anterograde and retrograde flow. Case 1 shows direct DTA-lacrimal artery anastomosis. In cases 2 to 4, the DTA is shown originating from the internal maxillary artery (IMAX) following its anatomical course. Retrograde flow from the DTA into the IMAX can then lead to anterograde flow into branches connecting to the IMAX including the superficial temporal artery, infraorbital artery, and middle meningeal artery. These arteries then form collaterals with the OA.

Conclusions:
Our study is the first to elucidate 4 potential routes for filler-induced OA occlusion originating from DTAs in the supraperiosteal plane. These pathways involve retrograde flow, a mechanism previously suggested for filler-induced occlusion. Notably, the likelihood of these pathways being traversed may be low due to their length and amount of filler volume required; however, it is not impossible.
Working Conditions in Complementary and Integrative Healthcare Professions
Authors: Whitley Margaret D. , Faydenko Jocelyn , Madigan Dana , Finnell John S. 
Published: January 2025

Objective
The study aimed to describe working conditions among complementary and integrative healthcare (CIH) providers, specifically acupuncturists, chiropractors, massage therapists, midwives, and naturopathic doctors.

Methods
We used cross-sectional Occupational Information Network data (2013–2021) for five CIH occupations. We examined means and 95% confidence intervals (CIs) for 10 variables that represented positive conditions, ergonomic demands, psychosocial demands, and schedule demands. We compared CIH to conventional healthcare and non-healthcare occupations.

Results
CIH occupations had relatively high degrees of positive conditions, moderate degrees of psychosocial demands, and moderate hours/scheduling. Massage therapists, chiropractors, and acupuncturists reported more ergonomic hazards (eg, 1–5 scale where 5 is the highest, mean bending/twisting frequency for chiropractors is 3.43 [95% CI, 3.80–4.05] compared to 2.17 for midwives [95% CI, 1.97–2.36] and 1.96 for managers [95% CI, 1.42–2.51]).

Conclusions
CIH occupations generally had healthy working conditions, although ergonomic hazards were prominent.
Too Soon to Breathe Easy
Authors: Creswell Paul D. , McCoy Katherine E. , Modji Komi K.S. , Morris Collin R. , Bedno Sheryl 
Published: January 2025

Objectives
This study aimed to describe asbestosis morbidity and mortality in two statewide samples. We considered trends, demographic disparities, and excess mortality.

Methods
We assessed trends and demographic differences in asbestosis morbidity using hospital and emergency department (ED) visits. We calculated asbestosis mortality rates using vital records data and computed proportional mortality ratios (PMRs) to assess excess deaths by standardized industry and occupation codes.

Results
Asbestosis diagnoses peaked in 2008 and have declined since that time. Several occupations and industry codes, including those in Production/Manufacturing, Construction, and Transportation, were associated with an excess burden of asbestosis mortality.

Conclusions
Despite declining diagnoses, asbestosis remains a risk for workers. Our findings of excess mortality for Transportation-related industry and occupation codes are unique and may indicate previously unrecognized risks in these jobs.
Nomogram model based on serum chitotriosidase activity to predict coronary artery aneurysm in Kawasaki disease
Authors: Wang Rui , Wei Dan , Gu Min , Mi Jiao , Hu Xing , Pu Wanli 
Published: January 2025

Objective
Kawasaki disease (KD) is a common children’s disease with unknown etiology, which easily involves coronary artery and causes serious cardiovascular sequelae. The purpose was to investigate the relationship between chitotriosidase activity and coronary artery aneurysm (CAA) and develop and validate a nomogram to predict CAA in KD patients.

Methods
A total of 338 KD patients were included in this study. Differences analysis compared baseline characteristics and multivariate logistic regression analysis to determine independent risk factors for CAA in KD patients. Based on this independent risk factor, the nomogram was constructed and validated.

Results
Of 338 KD patients, 107 patients developed CAA. Multivariate logistic regression analysis identified that low-density lipoprotein (LDL) [odds ratio (OR):1.456, 95% confidence interval (CI): 1.062–1.996], age (OR: 0.986, 95% CI: 0.974–0.998), neutrophil-to-lymphocyte ratio (NLR) (OR: 1.098, 95% CI: 1.020–1.182), and chitotriosidase activity (OR: 1.115, 95% CI: 1.111–1.192) were independent predictors for CAA. The nomogram was established based on serum chitotriosidase activity and clinical characteristics, and this nomogram has demonstrated to be of potential value in clinical practice using the receiver operating characteristic curve, calibration curve, and decision curve analysis.

Conclusion
LDL, age, NLR, and chitotriosidase activity were independent risk factors for CAA. Based on this independent risk factor, the nomogram was constructed to guide clinicians to effectively predict CAA and adopt appropriate interventions such as more aggressive anti-inflammatory and more frequent follow-up.