bluuebunny/crossref_metadata_2025_split huggingface dataset:
A REASSESSMENT OF THE ORIGIN OF THE POLYPLOID WHEATS
Authors: Kimber Gordon 
Published: January 2021

ABSTRACT
The diploid species that donated the A and D genomes to the polyploid wheats have been recognized for some time. New evidence indicates that Triticum speltoides cannot be the B genome donor to T. turgidum or T. aestivum. T. speltoides is probably homologous to the G genome of T. timopheevii. The donor of the B genome to T. turgidum and T. aestivum is currently unrecognized.
ON THE ORIGIN OF THE CULTIVATED CHENOPODS (CHENOPODIUM)
Authors: Heiser Charles B , Nelson David C 
Published: January 2021

ABSTRACT
On the basis of morphology Chenopodium quinoa of the Andes and C. nuttalliae of Mexico appear to be very closely related species. Artificial hybrids have been secured between the two. It is suggested that both species may have been derived from the same original wild type. A weedy quinoa, C. quinoa var. melanospermum, is known from South America, but as yet a weed race closely related to C. nutalliae has not been reported from Mexico.
MISREPAIR MUTAGENESIS IN BACTERIOPHAGE T4
Authors: Green Ronald R , Drake John W 
Published: January 2021

ABSTRACT
The T4 mutations px, y and 1206 inactivate an error-prone recombination-like repair system, reducing or abolishing mutagenesis by UV irradiation, MMS, and white light irradiation in the presence of the photosensitizer 8MOP. Both px and y increase some spontaneous mutation rates and slightly enhance proflavin mutagenesis; neither mutation affects thymineless or 2AP mutagenesis appreciably, but both mildly enhance 5BU mutagenesis. The mutation hm promotes UV, MMS, photodynamic, thymineless, and base analog mutagenesis, in addition to spontaneous base pair substitution mutation. It does not, however, markedly affect proflavin mutagenesis. The px mutation maps in the vicinity of genes 41-56, and the hm mutation maps in the vicinity of genes rI-v.
Seismic evidence for a plume-modified oceanic lithosphere–asthenosphere system beneath Cape Verde
Authors: Liu Xin , Zhao Dapeng 
Published: January 2021

SUMMARYWe determine a new 3-D shear wave velocity (Vs) model down to 400 km depth beneath the Cape Verde hotspot that is far from plate boundaries. This Vs model is obtained by using a new method of jointly inverting P- and S-wave receiver functions, Rayleigh-wave phase-velocity data and S-wave arrival times of teleseismic events. Two Vs discontinuities at ∼15 and ∼60 km depths are revealed beneath volcanic islands, which are interpreted as the Moho discontinuity and the Gutenberg (G) discontinuity. Between the north and south islands, obvious high-Vs anomalies exist in the uppermost mantle down to a depth of ∼100–150 km beneath the Atlantic Ocean, whereas obvious low-Vs anomalies exist in the uppermost mantle beneath the volcanic islands including the active Fogo volcano. These low-Vs anomalies merge into a significant column-like low-Vs zone at depths of ∼150–400 km beneath the Cape Verde swell. We propose that these features in the upper mantle reflect a plume-modified oceanic lithosphere–asthenosphere system beneath the Cape Verde hotspot.
Effective recruitment strategies for African-American men and women: the Nutritious Eating with Soul study
Authors: Turner-McGrievy Gabrielle M , Wilson Mary J , Bailey Shiba , Bernhart John A , Wilcox Sara , Frongillo Edward A , Murphy E Angela , Hutto Brent 
Published: January 2021

Abstract
Previous studies have found it challenging to recruit African-American (AA) participants into health education research studies. The goal of this article is to describe the recruitment methods used for the Nutritious Eating with Soul (NEW Soul) study, a 2-year randomized behavioral health education intervention, conducted in two cohorts, with emphasis on methods used for reaching men. Participants indicated how they learned about the study on an online screening questionnaire from a list of the recruitment strategies we employed. Due to limited recruitment of men in Cohort 1, recruitment strategies for Cohort 2 focused on reaching men. Across the two cohorts, a total of 568 (23% men) participants completed the online screener and 159 (21% men) completed all baseline assessments and enrolled in the study. The most effective methods for completing screening questionnaires were radio ads, referrals from friends and family, TV interviews, social media posts and community events. Men were primarily recruited via radio ads, whereas women were more often recruited through TV and social media. Radio was an effective way to recruit AA adults into nutrition interventions, particularly men. In addition, low-cost methods, such as personal referrals, social media posts and community events were also effective strategies.
Loss of sarcospan exacerbates pathology inmdxmice, but does not affect utrophin amelioration of disease
Authors: Gibbs Elizabeth M , McCourt Jackie L , Shin Kara M , Hammond Katherine G , Marshall Jamie L , Crosbie Rachelle H 
Published: January 2021

AbstractThe dystrophin–glycoprotein complex (DGC) is a membrane adhesion complex that provides structural stability at the sarcolemma by linking the myocyte’s internal cytoskeleton and external extracellular matrix. In Duchenne muscular dystrophy (DMD), the absence of dystrophin leads to the loss of the DGC at the sarcolemma, resulting in sarcolemmal instability and progressive muscle damage. Utrophin (UTRN), an autosomal homolog of dystrophin, is upregulated in dystrophic muscle and partially compensates for the loss of dystrophin in muscle from patients with DMD. Here, we examine the interaction between Utr and sarcospan (SSPN), a small transmembrane protein that is a core component of both UTRN–glycoprotein complex (UGC) and DGC. We show that additional loss of SSPN causes an earlier onset of disease in dystrophin-deficient mdx mice by reducing the expression of the UGC at the sarcolemma. In order to further evaluate the role of SSPN in maintaining therapeutic levels of Utr at the sarcolemma, we tested the effect of Utr transgenic overexpression in mdx mice lacking SSPN (mdx:SSPN −/−:Utr-Tg). We found that overexpression of Utr restored SSPN to the sarcolemma in mdx muscle but that the ablation of SSPN in mdx muscle reduced Utr at the membrane. Nevertheless, Utr overexpression reduced central nucleation and improved grip strength in both lines. These findings demonstrate that high levels of Utr transgenic overexpression ameliorate the mdx phenotype independently of SSPN expression but that loss of SSPN may impair Utr-based mechanisms that rely on lower levels of Utr protein.
Effect of DNA repair inhibitor AsiDNA on the incidence of telomere fusion in crisis
Authors: Subecz Chloé , Sun Jian-Sheng , Roger Lauréline 
Published: January 2021

Abstract
Telomere fusions lead to a state of genomic instability, and are thought to drive clonal evolution and tumorigenesis. Telomere fusions occur via both Classical and Alternative Non-Homologous End Joining repair pathways. AsiDNA is a DNA repair inhibitor that acts by mimicking a DNA double strand break (DSB) and hijacking the recruitment of proteins involved in various DNA repair pathways. In this study, we investigated whether the inhibition of DSB-repair pathways by AsiDNA could prevent telomere fusions during crisis.
The present study showed that AsiDNA decreased the frequency of telomere fusions without affecting the rate of telomere erosion. Further, it indicated that AsiDNA does not impact the choice of the repair pathway used for the fusion of short dysfunctional telomeres.
AsiDNA is thought to prevent short telomeres from fusing by inhibiting DNA repair. An alternative, non-mutually exclusive possibility is that cells harbouring fusions preferentially die in the presence of AsiDNA, thus resulting in a reduction in fusion frequency.
This important work could open the way for investigating the use of AsiDNA in the treatment of tumours that have short dysfunctional telomeres and/or are experiencing genomic instability.
Inferring recombination patterns in African populations
Authors: van Eeden Gerald , Uren Caitlin , Möller Marlo , Henn Brenna M 
Published: January 2021

AbstractAlthough several high-resolution recombination maps exist for European-descent populations, the recombination landscape of African populations remains relatively understudied. Given that there is high genetic divergence among groups in Africa, it is possible that recombination hotspots also diverge significantly. Both limitations and opportunities exist for developing recombination maps for these populations. In this review, we discuss various recombination inference methods, and the strengths and weaknesses of these methods in analyzing recombination in African-descent populations. Furthermore, we provide a decision tree and recommendations for which inference method to use in various research contexts. Establishing an appropriate methodology for recombination rate inference in a particular study will improve the accuracy of various downstream analyses including but not limited to local ancestry inference, haplotype phasing, fine-mapping of GWAS loci and genome assemblies.
Adiposity rebound and cardiometabolic health in childhood: results from the Generation XXI birth cohort
Authors: Fonseca Maria João , Moreira Carla , Santos Ana Cristina 
Published: January 2021

AbstractBackgroundWe aimed to evaluate the association of adiposity rebound (AR) timing on cardiometabolic health in childhood.MethodsParticipants were part of the Generation XXI birth cohort, enrolled in 2005/2006 in Porto. All measurements of the child’s weight and height performed by health professionals as part of routine healthcare were collected. Individual body mass index (BMI) curves were fitted for 3372 children, using mixed-effects models with smooth spline functions for age and random effects. The AR was categorized into very early (&lt;42 months), early (42–59 months), normal (60–83 months) and late (≥84 months). At age 10 years, cardiometabolic traits were assessed and age- and sex-specific z-scores were generated. Adjusted regression coefficients and 95% confidence intervals [β (95% CI)] were computed.ResultsThe mean age at AR was 61.9 months (standard deviations 15.7). Compared with children with normal AR, children with very early or early AR had higher z-scores for BMI [β = 0.40 (95% CI: 0.28; 0.53); β = 0.21 (95% CI: 0.12; 0.30)], waist circumference [β = 0.33 (95% CI: 0.23; 0.43); β = 0.18 (95% CI: 0.10; 0.25)], waist–height ratio [β = 0.34 (95% CI: 0.24; 0.44); β = 0.14 (95% CI: 0.07; 0.22)], fat mass index [β = 0.24 (95% CI: 0.15; 0.33); β = 0.14 (95% CI: 0.08; 0.21)], fat-free mass index [β = 0.25 (95% CI: 0.14; 0.35); β = 0.11 (95% CI: 0.03; 0.19)], systolic blood pressure [β = 0.10 (95% CI: 0.01; 0.20); β = 0.08 (95% CI: 0.01; 0.15)], insulin [β = 0.16 (95% CI: 0.04; 0.29); β = 0.10 (95% CI: 0.01; 0.19)], HOMA-IR [β = 0.17 (95% CI: 0.04; 0.29); β = 0.10 (95% CI: 0.03; 0.19)] and C-reactive protein [β = 0.14 (95% CI: 0.02; 0.26); β = 0.10 (95% CI: 0.01; 0.19)]. Children with very early AR also had worse levels of diastolic blood pressure [β = 0.09 (95% CI: 0.02; 0.16)], triglycerides [β = 0.21 (95% CI: 0.08; 0.34)] and high-density lipoprotein cholesterol [β=−0.18 (95% CI: −0.31; −0.04)]. When analysed continuously, each additional month of age at the AR was associated with healthier cardiometabolic traits.ConclusionThe earlier the AR, the worse the cardiometabolic health in late childhood, which was consistently shown across a wide range of outcomes and in the categorical and continuous approach.
Research on flexible job shop scheduling with low-carbon technology based on quantum bacterial foraging optimization
Authors: Ning Tao , Wang Zi , Duan Xiaodong , Liu Xiangdong 
Published: January 2021

Abstract
In order to further reduce the carbon emission of manufacturing process in flexible job shop, a multi-objective integrated optimization model of flexible job-shop scheduling (FJSP) is proposed. A mathematics model is built in this paper to minimize makespan, total workload of machines and carbon emissions of machines and to optimize process method of each machine characteristic, process sequence and machine allocation. Considering many parameters are interactional and to be optimized in the proposed model, a quantum bacterial foraging optimization is designed to code the related parameters. On the basis of Kacem example through experimental simulation, the performance of the proposed method in the paper was analysed with ANOVA, and by comparing with the algorithms of current separated optimization method of process planning and scheduling, the effect of proposed integrated optimization model on reducing carbon emission in practical requirements of FJSP is verified.
Fast and accurate approximations to fractional powers of operators
Authors: Aceto Lidia , Novati Paolo 
Published: January 2021

Abstract
In this paper we consider some rational approximations to the fractional powers of self-adjoint positive operators, arising from the Gauss–Laguerre rules. We derive practical error estimates that can be used to select a priori the number of Laguerre points necessary to achieve a given accuracy. We also present some numerical experiments to show the effectiveness of our approaches and the reliability of the estimates.
Tetravalent Rabies-Vectored Filovirus and Lassa Fever Vaccine Induces Long-term Immunity in Nonhuman Primates
Authors: Kurup Drishya , Fisher Christine R , Scher Gabrielle , Yankowski Catherine , Testa AnnaMarie , Keshwara Rohan , Abreu-Mota Tiago , Lambert Rachael , Ferguson Melissa , Rinaldi William , Ruiz Leonard , Wirblich Christoph , Schnell Matthias J 
Published: January 2021

Abstract

Background
The objective of this study is to evaluate the immunogenicity of adjuvanted monovalent rabies virus (RABV)–based vaccine candidates against Ebola virus (FILORAB1), Sudan virus (FILORAB2), Marburg virus (FILORAB3), Lassa virus (LASSARAB1), and combined trivalent vaccine candidate (FILORAB1–3) and tetravalent vaccine candidate (FILORAB1–3 and LASSARAB) in nonhuman primates.

Methods
Twenty-four Macaca fascicularis were randomly assigned into 6 groups of 4 animals. Each group was vaccinated with either a single adjuvanted vaccine, the trivalent vaccine, or the tetravalent vaccine at days 0 and 28. We followed the humoral immune responses for 1 year by antigen-specific enzyme-linked immunosorbent assays and RABV neutralization assays.

Results
High titers of filovirus and/or Lassa virus glycoprotein-specific immunoglobulin G were induced in the vaccinated animals. There were no significant differences between immune responses in animals vaccinated with single vaccines vs trivalent or tetravalent vaccines. In addition, all vaccine groups elicited strong rabies neutralizing antibody titers. The antigen-specific immune responses were detectable for 1 year in all groups.

Conclusions
In summary, this study shows the longevity of the immune responses up to 365 days for a pentavalent vaccine—against Ebola virus, Sudan virus, Marburg virus, Lassa virus, and RABV—using a safe and effective vaccine platform.
Development and Validation of an Analytical Method for Quantitation of Bisphenol S in Rodent Plasma, Amniotic Fluid and Fetuses by UPLC–MS-MS
Authors: Rehder Silinski Melanie A , Fletcher Brenda L , Fernando Reshan A , Robinson Veronica G , Waidyanatha Suramya 
Published: January 2021

Abstract
Bisphenol S (BPS) has been detected in personal care products, water, food and indoor house dust, demonstrating the potential for human exposure. Due to limited data to characterize the hazard of BPS, the National Toxicology Program (NTP) is investigating the toxicity of BPS in rodent models. Generating systemic exposure data is integral to putting toxicological findings into context. The objective of this work was to develop and validate a method to quantitate free (unconjugated parent) and total (free and all conjugated forms of) BPS in rodent plasma, amniotic fluid and fetal homogenate in support of NTP studies. The method used incubation with (total BPS) and without (free BPS) deconjugating enzyme and then protein precipitation followed by ultra-performance liquid chromatography-tandem mass spectrometry. In Sprague Dawley rat plasma, the method was linear (r ≥ 0.99) over the range 5–1,000 ng/mL, accurate (mean relative error (RE) ≤ ±10.5%) and precise (relative standard deviation (RSD) ≤ 7.7%). Mean recoveries were ≥93.1% for both free and total analyses. The limits of detection were 1.15 ng/mL (free) and 0.862 ng/mL (total) in plasma. The method was evaluated in the following study matrices: (i) male Hsd:Sprague Dawley®SD® (HSD) rat plasma, (ii) female HSD rat plasma, (iii) male B6C3F1 mouse plasma, (iv) female B6C3F1 mouse plasma, (v) HSD rat gestational day (GD) 18 dam plasma, (vi) HSD rat GD 18 amniotic fluid, (vii) HSD rat GD 18 fetal homogenate and (viii) HSD rat postnatal day 4 pup plasma (mean %RE ≤ ±8.2 and %RSD ≤ 8.7). Stability of BPS in extracted samples was demonstrated for up to 7 days at various temperatures, and freeze–thaw stability was demonstrated after three cycles over 7 days. BPS in various matrices stored at −80°C for at least 60 days was within 92.1–115% of Day 0 concentrations, demonstrating its stability in these matrices. These data demonstrate that this simple method is suitable for determination of free and total BPS in plasma, amniotic fluid and fetuses following exposure of rodents to BPS.
Complicated sinusitis with sphenopalatine artery thrombosis in a COVID-19 patient: a case report
Authors: Ahmed Omar , Aladham Youssef , Mahmood Sara , Abdelnaby Moustafa Mohamed 
Published: January 2021

Abstract
COVID-19 has been a mystery against healthcare professionals. We herein report a rare presentation of complicated sinusitis with pre-septal cellulitis and hard palatal necrosis in a COVID-19 patient. A 52-year-old male was admitted to the hospital with typical COVID manifestations where he had two successive COVID-19 positive swabs. During his admission, he developed symptoms of right orbital complications of sinusitis along with both clinical and radiological evidence of ipsilateral hard palatal necrosis. Imaging confirmed a diagnosis of right pan-sinusitis complicated with right pre-septal infection and hard palatal bony defect on the same side. Our case focuses on the possible association between these manifestations and the known thromboembolic complications of COVID-19. Ongoing management of such complicated rare cases should be through multidisciplinary team.
Genome-wide association study reveals the genetic complexity of fructan accumulation patterns in barley grain
Authors: Matros Andrea , Houston Kelly , Tucker Matthew R , Schreiber Miriam , Berger Bettina , Aubert Matthew K , Wilkinson Laura G , Witzel Katja , Waugh Robbie , Seiffert Udo , Burton Rachel A 
Published: January 2021

Abstract
We profiled the grain oligosaccharide content of 154 two-row spring barley genotypes and quantified 27 compounds, mainly inulin- and neoseries-type fructans, showing differential abundance. Clustering revealed two profile groups where the ‘high’ set contained greater amounts of sugar monomers, sucrose, and overall fructans, but lower fructosylraffinose. A genome-wide association study (GWAS) identified a significant association for the variability of two fructan types: neoseries-DP7 and inulin-DP9, which showed increased strength when applying a novel compound ratio-GWAS approach. Gene models within this region included three known fructan biosynthesis genes (fructan:fructan 1-fructosyltransferase, sucrose:sucrose 1-fructosyltransferase, and sucrose:fructan 6-fructosyltransferase). Two other genes in this region, 6(G)-fructosyltransferase and vacuolar invertase1, have not previously been linked to fructan biosynthesis and showed expression patterns distinct from those of the other three genes, including exclusive expression of 6(G)-fructosyltransferase in outer grain tissues at the storage phase. From exome capture data, several single nucleotide polymorphisms related to inulin- and neoseries-type fructan variability were identified in fructan:fructan 1-fructosyltransferase and 6(G)-fructosyltransferase genes. Co-expression analyses uncovered potential regulators of fructan biosynthesis including transcription factors. Our results provide the first scientific evidence for the distinct biosynthesis of neoseries-type fructans during barley grain maturation and reveal novel gene candidates likely to be involved in the differential biosynthesis of various types of fructan in barley.
All together now: regulation of the iron deficiency response
Authors: Riaz Nabila , Guerinot Mary Lou 
Published: January 2021

Abstract
Iron (Fe) is one of the essential micronutrients required by both plants and animals. In humans, Fe deficiency causes anemia, the most prevalent nutritional disorder. Most people rely on plant-based foods as their major Fe source, but plants are a poor source of dietary Fe. Therefore, there is a critical need to better understand the mechanisms involved in the uptake and trafficking of Fe and how plants adapt to Fe deficiency. Fe participates in key cellular functions such as photosynthesis and respiration. Perturbations of Fe uptake, transport, or storage affect plant growth as well as crop yield and plant product quality. Excess Fe has toxic effects due to its high redox activity. Plants, therefore, tightly regulate Fe uptake, distribution, and allocation. Here, we review the regulatory mechanisms involved at the transcriptional and post-translational levels that are critical to prevent Fe uptake except when plants experience Fe deficiency. We discuss the key regulatory network of basic helix–loop–helix (bHLH) transcription factors, including FIT, subgroup Ib, subgroup IVc, and URI (bHLH121), crucial for regulating Fe uptake in Arabidopsis thaliana. Furthermore, we describe the regulators of these transcription factors that either activate or inhibit their function, ensuring optimal Fe uptake that is essential for plant growth.
Globalised citizenship and the perceived legitimacy of immigration control: narratives and acts of resistance in immigration detention
Authors: van Houte Marieke , Leerkes Arjen , Slipper Alice , Breuls Lars 
Published: January 2021

AbstractThis article considers the legitimacy deficits of immigration control in the eyes of unwanted migrants. We explore the consequences of globalisation-related changes in the institution of citizenship for the perceived legitimacy and operation of immigration control. The study is based on ethnographic research and in-depth interviews in 2018 with 35 migrants in the Detention Centre Rotterdam, the Netherlands. We find that immigration detainees use both denationalised and transnational/cosmopolitan definitions of citizenship and belonging to contest the legitimacy of restrictive admission requirements and, to a lesser extent, the authority of states to stipulate and implement admission requirements. Based on these narratives, immigration detainees engage in forms of resistance that are meant to diminish the likelihood of deportation (‘instrumental resistance’) and in forms of resistance that are unlikely to change the outcome of the deportation procedure yet do make immigration control more costly for states (‘expressive resistance’). The narratives and strategies of resistance seem correlated with length of stay: settled migrants seem more inclined to use denationalised repertoires and instrumental resistance. Our analysis confirms the need for migration scholars to pay more attention to changing social norms regarding the perceived legitimacy of immigration control for the operation and outcomes of immigration control. The results are therefore relevant for our thinking about the future of migration governance in the context of globalisation-related changes in the institution of citizenship.