bluuebunny/crossref_metadata_2025_split huggingface dataset:
In situ observations of ions and magnetic field around Phobos: the mass spectrum analyzer (MSA) for the Martian Moons eXploration (MMX) mission
Authors: Yokota Shoichiro , Terada Naoki , Matsuoka Ayako , Murata Naofumi , Saito Yoshifumi , Delcourt Dominique , Futaana Yoshifumi , Seki Kanako , Schaible Micah J. , Asamura Kazushi , Kasahara Satoshi , Nakagawa Hiromu , Nishino Masaki N. , Nomura Reiko , Keika Kunihiro , Harada Yuki , Imajo Shun 
Published: December 2021

AbstractThe mass spectrum analyzer (MSA) will perform in situ observations of ions and magnetic fields around Phobos as part of the Martian Moons eXploration (MMX) mission to investigate the origin of the Martian moons and physical processes in the Martian environment. MSA consists of an ion energy mass spectrometer and two magnetometers which will measure velocity distribution functions and mass/charge distributions of low-energy ions and magnetic field vectors, respectively. For the MMX scientific objectives, MSA will observe solar wind ions, those scattered at the Phobos surface, water-related ions generated in the predicted Martian gas torus, secondary ions sputtered from Phobos, and escaping ions from the Martian atmosphere, while monitoring the surrounding magnetic field. MSA will be developed from previous instruments for space plasma missions such as Kaguya, Arase, and BepiColombo/Mio to contribute to the MMX scientific objectives.
Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone With Minimal Residual Disease Response-Adapted Therapy in Newly Diagnosed Multiple Myeloma
Authors: Costa Luciano J. , Chhabra Saurabh , Medvedova Eva , Dholaria Bhagirathbhai R. , Schmidt Timothy M. , Godby Kelly N. , Silbermann Rebecca , Dhakal Binod , Bal Susan , Giri Smith , D'Souza Anita , Hall Aric , Hardwick Pamela , Omel James , Cornell Robert F. , Hari Parameswaran , Callander Natalie S. 
Published: December 2021

PURPOSE The MASTER trial combined daratumumab, carfilzomib, lenalidomide, and dexamethasone (Dara-KRd) in newly diagnosed multiple myeloma (NDMM), using minimal residual disease (MRD) by next-generation sequencing (NGS) to inform the use and duration of Dara-KRd post-autologous hematopoietic cell transplantation (AHCT) and treatment cessation in patients with two consecutive MRD-negative assessments. METHODS This multicenter, single-arm, phase II trial enrolled patients with NDMM with planed enrichment for high-risk cytogenetic abnormalities (HRCAs). Patients received Dara-KRd induction, AHCT, and Dara-KRd consolidation, according to MRD status. MRD was evaluated by NGS at the end of induction, post-AHCT, and every four cycles (maximum of eight cycles) of consolidation. Primary end point was achievement of MRD negativity (< 10–5). Patients with two consecutive MRD-negative assessments entered treatment-free MRD surveillance. RESULTS Among 123 participants, 43% had none, 37% had 1, and 20% had 2+ HRCA. Median age was 60 years (range, 36-79 years), and 96% had MRD trackable by NGS. Median follow-up was 25.1 months. Overall, 80% of patients reached MRD negativity (78%, 82%, and 79% for patients with 0, 1, and 2+ HRCA, respectively), 66% reached MRD < 10–6, and 71% reached two consecutive MRD-negative assessments during therapy, entering treatment-free surveillance. Two-year progression-free survival was 87% (91%, 97%, and 58% for patients with 0, 1, and 2+ HRCA, respectively). Cumulative incidence of MRD resurgence or progression 12 months after cessation of therapy was 4%, 0%, and 27% for patients with 0, 1, or 2+ HRCA, respectively. Most common serious adverse events were pneumonia (6%) and venous thromboembolism (3%). CONCLUSION Dara-KRd, AHCT, and MRD response-adapted consolidation leads to high rate of MRD negativity in NDMM. For patients with 0 or 1 HRCA, this strategy creates the opportunity of MRD surveillance as an alternative to indefinite maintenance.
Characterization of Subtypes of BRAF-Mutant Papillary Thyroid Cancer Defined by Their Thyroid Differentiation Score
Authors: Boucai Laura , Seshan Venkatraman , Williams Michelle , Knauf Jeffrey A , Saqcena Mahesh , Ghossein Ronald A , Fagin James A 
Published: December 2021

Abstract

Context
The BRAFV600E mutation has been associated with more advanced clinical stage in papillary thyroid cancer (PTC) and decreased responsiveness to radioiodine (RAI). However, some BRAF mutant PTCs respond to RAI and have an indolent clinical behavior suggesting the presence of different subtypes of BRAF mutant tumors with distinct prognosis.

Objective
To characterize the molecular and clinical features of 2 subtypes of BRAF-mutant PTCs defined by their degree of expression of iodine metabolism genes.

Design
227 BRAF-mutant PTCs from the Cancer Genome Atlas Thyroid Cancer study were divided into 2 subgroups based on their thyroid differentiation score (TDS): BRAF-TDShi and BRAF-TDSlo. Demographic, clinico-pathological, and molecular characteristics of the 2 subgroups were compared.

Results
Compared to BRAF-TDShi tumors (17%), BRAF-TDSlo tumors (83%) were more frequent in blacks and Hispanics (6% vs 0%, P = 0.035 and 12% vs 0%, P = 0.05, respectively), they were larger (2.95 ± 1.7 vs 2.03 ± 1.5, P = 0.002), with more tumor-involved lymph nodes (3.9 ± 5.8 vs 2.0 ± 4.2, P = 0.042), and a higher frequency of distant metastases (3% vs 0%, P = 0.043). Gene set enrichment analysis showed positive enrichment for RAS signatures in the BRAF-TDShi cohort, with corresponding reciprocal changes in the BRAF-TDSlo group. Several microRNAs (miRs) targeting nodes in the transforming growth factor β (TGFβ)-SMAD pathway, miR-204, miR-205, and miR-144, were overexpressed in the BRAF-TDShi group. In the subset with follow-up data, BRAF-TDShi tumors had higher complete responses to therapy (94% vs 57%, P &lt; 0.01) than BRAF-TDSlo tumors.

Conclusion
Enrichment for RAS signatures, key genes involved in cell polarity and specific miRs targeting the TGFβ-SMAD pathway define 2 subtypes of BRAF-mutant PTCs with distinct clinical characteristics and prognosis.
Integrin α6β4 requires plectin and vimentin for adhesion complex distribution and invasive growth
Authors: Qi Lei , Knifley Teresa , Chen Min , O'Connor Kathleen L. 
Published: December 2021

ABSTRACT
Integrin α6β4 binds plectin to associate with vimentin; however, the biological function remains unclear. Here, we utilized various integrin β4 mutants and CRISPR-Cas9 editing to investigate this association. Upon laminin binding, integrin α6β4 distinctly distributed peripherally as well as centrally, proximal to the nucleus. Upon fibronectin addition, integrin α6β4 was centrally recruited to large focal adhesions (FAs) and enhanced Fak (also known as PTK2) phosphorylation. Integrin β4 plectin-binding mutants or genetic deletion of plectin inhibited β4 recruitment to FAs and integrin α6β4-enhanced cell spreading, migration and three-dimensional invasive growth. Loss of the β4 signaling domain (but retaining plectin binding) blocked migration and invasiveness but not cell spreading, recruitment to FAs or colony growth. Immunostaining revealed that integrin α6β4 redistributed vimentin perinuclearly, where it colocalized with plectin and FAs. Depletion of vimentin completely blocked integrin β4-enhanced invasive growth, Fak phosphorylation and proliferation in three dimensions but not two dimensions. In summary, we demonstrate the essential roles of plectin and vimentin in promoting an invasive phenotype downstream of integrin α6β4.
This article has an associated First Person interview with the first author of the paper.
Andrzej Chwalba, Przegrane zwycięstwo. Wojna polsko-bolszewicka 1918-1920, Wołowiec 2020, ss. 387.
Authors: Goclon Jacek Arkadiusz 
Published: December 2021

Recenzja książki Andrzeja Chwalby Przegrane zwycięstwo. Wojna polsko-bolszewicka 1918-1920, Wołowiec 2020, ss. 387.
Ogólnopolska konferencja naukowa „Badania historii kobiet polskich na tle porównawczym. Kierunki, problematyka, perspektywy”. Białystok 11–13 czerwca 2021
Authors: Wodniak Katarzyna 
Published: December 2021

Sprawozdanie z konferencji naukowej „Badania historii kobiet polskich na tle porównawczym. Kierunki, problematyka, perspektywy”. Białystok 11–13 czerwca 2021
COMPARACIÓN ENTRE EL MODELO PROBIT Y EL MODELO DE HILL PARA DETERMINAR LA EFICACIA DE IVERMECTINA SOBRE LARVAS DE Rhipicephalus (Boophilus) microplus (ACARI, IXODIDA: IXODIDAE) MEDIANTE LA TÉCNICA DE INMERSIÓN.
Authors: Torrents J 
Published: December 2021

The aim of this study was to propose an alternative statistic treatment for the results obtained by testing the in vitro efficacy of ivermectin (IVM) against R. microplus using the larval immersion test in order to detect the emergence of resistant strains. The statistical analysis of the results obtained by this technique is standardized by the FAO who proposes the use of the Probit model. However there are alternative mathematical models that allow a more precise analysis of experimental data generating more information as nonlinear logistic equation, also called the Hill model. The results of the IVM efficacy against a sensible strain of R. microplus were analysed whit both model. A comparison between the results obtained with PROBIT and Hill model showed that the last one was able to make a more precise fit of the experimental data, generating more information about small IVM concentrations. The C50 (13.58 ppm) obtained with Probit model result smaller than the obtained with the Hill model (14.24 ppm), however the C90, C99 and the discriminant dose (19.31 ppm, 25.74 ppm, 51.48 ppm) obtained with de Hill model were bigger than the obtained with the Probit model (17.50 ppm, 21.98 ppm, 43.96 ppm).
Faire œuvre de soi. Comparaison ethnographique des effets du néolibéralisme dans un mouvement spirituel et au sein d’un cercle d’affaires bruxellois
Authors: Fontaine Bénédicte , Vleminckx Justine 
Published: December 2021

Cet article, écrit à quatre mains, s’interroge sur les formes et les rôles que prennent les collectifs au sein des sociétés néolibérales, à partir d’une analyse comparée de deux recherches ethnographiques différentes : l’une menée par Bénédicte Fontaine au sein d’un cercle d’affaires bruxellois, le Club, et l’autre conduite par Justine Vleminckx au sein d’un mouvement spirituel international, la Rainbow Family. Nous proposons, à partir de nos deux terrains de recherche distincts, de donner à voir les expressions situées de l’idéologie néolibérale, et spécifiquement de l’injonction contemporaine à être entrepreneur de soi, c’est-à-dire à être manifeste­ment un sujet actif de sa vie et de son propre bonheur. Nous nous intéresserons aux discours particuliers que cette injonction génère et les conséquences qu’elle a sur les individus, leur rapport au monde et leur rapport au collectif.
Model fit and reliability of the Hungarian version of the Revised Exercise Addiction Inventory (EAI-R-HU)
Authors: Szabó Attila 
Published: December 2021

The Exercise Addiction Inventory (EAI) is a brief validated instrument adopted by many to assess the risk of exercise addiction. Its revised version (the EAI-R) has been recently validated in English with a predominantly male sample. The current work examined the model fit, validity and reliability of the Hungarian version of the EAI-R (EAI-R-HU). This cross-sectional study was conducted online. A convenience sample of regular exercisers (n = 253) completed the EAI-R-HU and answered demographic questions. Confirmatory factor analysis revealed a good model fit for the Hungarian version of the instrument. The internal reliability of the EAI-R-HU was (Cronbach’s α) .71. Considering the top 20% of the EAI-R-HU scores, 5.1% of the sample was at risk of exercise addiction. Team exercisers did not differ from individual exercisers in the risk of exercise addiction. Age and exercise characteristics predicted weakly but statistically significantly the risk of exercise addiction. The EAI-R-HU possesses a good model fit, and its internal reliability is acceptable. These findings complement the original revision of the EAI-R, based on a largely (87.7%) male sample compared to the current research primarily based on female participants (76.7%). While cultural differences might exist, the present results encourage the use of the EAI-R with women too and with Hungarian samples, in general.A Testedzésfüggőség Kérdőív (EAI) egy rövid, validált eszköz, amelyet a testedzésfüggőség kockázatának felmérésére használnak. Az angol nyelvű módosított változatát (EAI-R) nemrégiben egy többségében férfiakból álló mintán validálták. Jelen kutatás a magyar változat (EAI-R-HU) egyfaktoros elméleti struktúrájának illeszkedését, validitását, és a kérdőív belső megbízhatóságát vizsgálta. A hozzáférhetőségi mintavétellel zajló adatgyűjtés online történt. Rendszeresen edző önkéntesek (n = 253) kitöltötték a módosított EAI-t (EAI-R-HU) és megválaszolták a demográfiai kérdéseket. A megerősítő faktoranalízis jó modellillesztést mutatott, a skála belső megbízhatósága (Cronbach-α) pedig 0,71 volt. Az EAI-R-HU pontszámok felső 20%-át figyelembe véve, a jelen minta 5,14%-a volt feltételezhetően a testedzésfüggőség kockázatának kitéve. A csoportban edzők nem különböztek az egyéni edzést végzőktől a testedzésfüggőség kockázatát illetően. Az életkor és a testmozgás egyes jellemzői gyengén, de statisztikailag szignifikánsan prognosztizálták a testedzésfüggőség kockázatát. Az eredmények alapján az EAI-R-HU jó modellalkalmazással rendelkezik és a belső megbízhatósága elfogadható. Ezek a megállapítások kiegészítik az angol EAI-R változatát, amely nagyrészt (87,7%) férfi minta alapján jött létre, szemben a jelen kutatással, amely elsősorban női résztvevőkön alapszik (76,7%). Bár létezhetnek kulturális különbségek, a jelenlegi eredmények ösztönzik az EAI-R alkalmazását a nőknél is és az EAI-R-HU felhasználását magyar kutatásokban.
Feasibility study of compost as a partial substitute for fine aggregate in concrete
Authors: ArikaraVelan N. , Deepak V. , Dhinesh Kumar N. , Muthulingam G. , Vanitha S. , Karthigai Priya P. , Sabariraj Sachin 
Published: December 2021

Abstract
In this study, vermicompost is replaced for fine aggregate in geopolymer concrete (GPC). Initially mix design is made for GPC and mix proportion is proposed. The vermicompost is replaced at 5%, 10%, 15% and 20% with M sand in GPC. Result indicates the 5% replacement with vermicompost based geopolymer concrete (GPVC) has the compressive strength of 32 N mm−2 (M30 grade) whereas the compressive strength of control specimen made with GPC is 37 N mm−2. Other replacement shows 21 N mm−2, 14 N mm−2 and 11 N mm−2 respectively. The 5% replaced concrete cubes and control specimen are tested at an elevated temperature of 200°C, 400°C, 600°C and 800°C and compared with the control specimen. There is no significant difference observed in weight lost at control (GPC) and GPVC specimen. An elevated temperature, the weight loss is almost 4% at 200°C because of expulsion of water from the concrete. Afterwards only 2% weight loss is observed in remaining elevated temperature. The compressive strength loss is observed at an elevated temperature in GPC and GPVC specimen because of thermal incompatibility between aggregate and the binder. EDX results show M sand and compost contains Si, Al, C, Fe, Ca, Mg, Na and K and it is similar in the elemental composition and SEM image confirms vermicompost contains fine particles.
A mikroorganizmusok patogenitása és virulenciája: definíciók, példázatok és molekuláris háttérismeretek
Authors: Emődy Levente 
Published: December 2021

Összefoglaló. A fertőző betegségek kóroki hátterének felderítésére
irányuló törekvések hosszú időre tekintenek vissza. Fogalmakkal és
követelményekkel (posztulátumokkal) igyekeztek körülírni, hogy egy
mikroorganizmus mikor tekinthető egy adott fertőző betegség okozójának. Egy
patogén rendszertani kategóriába tartozó mikroorganizmus kimutatása a betegből
önmagában még nem elegendő bizonyíték arra, hogy a betegségnek valóban az a
kórokozója. Igazolni kell a továbbiakban, hogy rendelkezik azokkal a
virulenciafaktoroknak nevezett tényezőkkel, amelyek valójában képessé teszik az
adott betegség kiváltására. Robert Koch idejében csak fenotípusos ismeretek
álltak rendelkezésre, azok figyelembevételével fogalmazta meg posztulátumait.
Később, a megszerzett molekuláris ismeretek birtokában, a posztulátumokat
molekuláris szinten is értelmezték. A beteg személyét biológiai, szociális és
pszichés egységként kezelő holisztikus megközelítésnek is eleget téve, a
posztulátumokat a kórokozó mellett az esetben érintett gazdaszervezet egyedi
tulajdonságainak figyelembevételével tovább szélesítették. A dolgozat a fenti
kérdéseket példákkal illusztrálva tárgyalja, majd kitér a gyakorlati hasznosítás
lehetőségeire. Orv Hetil. 2021; 162(50): 1991–1999.
Summary. Efforts to explore the casual background of infectious
diseases have been ambitioned for a long time. Terms and requirements
(postulates) have been created to describe in which case a microorganism can be
regarded as a causative agent of a given infectious disease. Demonstration of a
representative of a pathogenic taxonomic category in the patient, however, does
not prove its causative role in itself. It should also be verified if the
microbe possesses the so-called virulence factors enabling it to trigger the
given disease. At the time when Robert Koch formulated his postulates, only
phenotypic characters were at his disposal. Later, in possession of a
substantial genetic knowledge, the postulates have been adapted to molecular
level. For having a holistic approach, the postulates have been extended also to
the host’s individual biological, social and psychological attributes. This
paper discusses the above issues with examples for illustration, and outlines
their practical applicabilities. Orv Hetil. 2021; 162(50): 1991–1999.
Effects of the drying method for flowers of Cynara cardunculus var. Altilis on milk coagulating properties
Authors: Tripaldi Carmela , Palocci Giuliano , Di Giovanni Sabrina , Iacurto Miriam , Steri Roberto , Campagna Maria Concetta , Di Russo Cristina , Zottola Tiziana 
Published: December 2021

In the production of some traditional cheeses from vegetable rennet, raw extracts of Cynara cardunculus flowers are used as the coagulant. During the preparation of this rennet, there are many factors that can influence its coagulation activity. We studied the flowers of Cynara cardunculus var. altilis to evaluate the effects of some of these factors: ripening stage of the flower at harvest, type of drying, part of the flower subjected to drying, toasting of the pistils, and maceration time of the pistils. The results show that it is possible to improve the coagulation activity of the traditional preparation of Cynara cardunculus flowers through some practices such as the rapid drying of the flowers/pistils at a controlled temperature, the toasting treatment of the pistils carried out after the slow drying of the flowers, and the extension of the extraction time to 24 h.
Condiciones de exposición y sensibilidad de la comunidad La Barra frente a los fenómenos meteorológicos extremos
Authors: Durán-Solarte Luz-Carina , Aguilar Ángel Andrés 
Published: December 2021

El presente artículo analiza las condiciones de vulnerabilidad de una comunidad pesquera frente a los fenómenos meteorológicos extremos agravados por el cambio climático. Se utiliza la metodología cualitativa, con apoyo en métodos geográficos, y con base en un estudio de caso: la comunidad afrodescendiente La Barra, localizada en el litoral Pacífico colombiano, en la desembocadura del río San Juan. Al existir un acceso limitado a la comunidad por sus condiciones geográficas, además de los requisitos de bioseguridad establecidos por la pandemia de COVID-19, se realizan un análisis documental y mapas multitemporales, a partir de imágenes satelitales, para visualizar los cambios espaciales de la línea costera de La Barra durante los años 2001, 2011 y 2019. Asimismo, se realizan entrevistas a expertos académicos y pobladores de la comunidad. La vulnerabilidad es entendida desde la escuela de pensamiento de la ciencia del cambio climático y la investigación sobre adaptación. Se concluye que no solo depende de los estímulos climáticos, sino también de las condiciones racializadas y marginalizadas de poblaciones afro ubicadas en territorios rurales aislados. De tal manera, la naturaleza social y política de los fenómenos meteorológicos puede transformarlos en eventos catastróficos para poblaciones vulnerables.

Abstract
This article analyses the vulnerability conditions of a fishing community facing the extreme meteorological phenomena aggravated by climate change. The methodology is qualitative, supported by geographic methods, based on the case study of the “La Barra afro-descendant community”, located in the Colombian Pacific Coast, in the mouth of San Juan River. As there is limited access to the community due to its geographical conditions, besides the biosecurity requirements due to the COVID-19 pandemic, a documentary analysis, as well as multi-temporal maps based on satellite images, show the spatial changes on the coastline of La Barra, during the years 2001, 2011 and 2019. In addition to the above, interviews with academic experts and community residents are conducted. The term “vulnerability” is understood from the school of thought of climate change science and adaptation research. It is concluded that the vulnerability not only depends on climatic stimuli but also on the racialized and marginalized conditions of Afro populations located in isolated rural territories. In that way, the social and political nature of the meteorological phenomena could transform them in catastrophic events for vulnerable populations.
Las características del espacio urbano como factores de exposición al COVID-19 en Ciudad de México
Authors: León Rojas Héctor Emanuel , Sierra Martínez Andrés Emiliano , De Aguinaga Padilla Francisco 
Published: December 2021

El artículo muestra la interacción entre las desigualdades socioespaciales acumuladas históricamente y la dinámica espacial del riesgo de contagio de COVID-19 en Ciudad de México. El objetivo es analizar la relación en el espacio urbano entre la localización de algunos factores de exposición al virus, identificados en la bibliografía especializada (vinculados con el transporte, la vivienda y el empleo) y la dinámica espacial de los contagios. Con métodos de análisis espacial, se vinculan conceptos de la ecología política y la teoría de la construcción social del riesgo. Se concluye que las condiciones de habitabilidad, el tiempo de traslado en medios de transporte colectivo y los niveles de desarrollo social son factores que determinan el comportamiento espacial de los contagios. Las periferias urbanas marginadas constituyen sitios desfavorecidos, en cuanto a las condiciones de exposición.
Abstract
The article shows the interaction between historically accumulated socio-spatial inequalities and the spatial dynamic of the risk of contagion of COVID-19 in Mexico City. The objective is to analyze the urban spatial relationship between the location of exposure factors to the virus, identified through literature review (associated with transport, living and employment), and the spatial dynamic of contagion. By using spatial analysis methods and techniques, concepts from political ecology and the theory of social construction of risk are connected. It is concluded that the conditions of habitability, the commuting time in public transportation and the levels of social development are determining factors of the spatial behaviour of contagion. Due to conditions of exposure, marginalized urban peripheries become disadvantaged places.