bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calcium Phosphate Cement Modified with Silicon Nitride/Tricalcium Phosphate Microgranules
Authors: Medvecky Lubomir , Stulajterova Radoslava , Giretova Maria , Sopcak Tibor , Faberova Maria , Hnatko Miroslav , Fenclova Tatana 
Published: August 2021

Abstract
Tetracalcium phosphate/monetite biocement was modified with 10 and 30 wt. % addition of highly porous silicon nitride/α-tricalcium phosphate (αTCP) microgranules with various content of αTCP. A composite cement powder mixture was prepared using mechanical homogenization of basic components. The accelerated release of dexamethasone from composite cement was revealed, which indicates their possible utilization for controlled drug release. The wet compressive strength of cements (<17 MPa) was significantly reduced (more than 30%) in comparison with the unmodified cement and both compressive strength and setting time were influenced by the content of αTCP in microgranules. The addition of microgranules caused a 20% decrease in final cement density. Microgranules with a higher fraction of αTCP showed good in vitro SBF bioactivity with precipitation of hydroxyapatite particles. Microstructure analysis of fractured cements demonstrated excellent interconnection between microgranules and cement calcium phosphate matrix, but also showed lower mechanical strength of microgranule cores.
Anti-dense fine speckled (DFS) antibody: its staining pattern in indirect immunofluorescence and its clinical relevance
Authors: Karahan Samet , Emre Şerife , Hörmet-Öz Hatice T. 
Published: August 2021

Abstract

Background: Dense fine speckled (DFS) pattern is defined by very intense, heterogeneous speckled staining of nucleoplasms of interphase HEp-2 cells and chromosomal areas of metaphase cells. The association of Anti-DFS70 and rheumatologic signs, symptoms, and diagnosis were evaluated.

Methods: One-hundred-eight anti-DFS70 positives who got consecutively admitted to the Rheumatology clinic between January and June 2020 were analyzed. The clinical and laboratory findings of positives for anti-DFS70 antibody were compared with those with DFS pattern ANA IFA staining rates. Also, anti-DFS70 positivity rates and their correlation with the DFS staining pattern were analyzed retrospectively in 1016 CTD patients.

Results: The most common complaint was joint pain seen in 77 (71.3%) and the most common laboratory abnormality was RF-positivity observed in 10/108 (9.3%) who had anti-DFS70 positivity. The most common ANA staining pattern was DFS (72/108; 66.7%); one-third had other than DFS. No statistical significance was found for the association of any of the rheumatological complaints and laboratory findings with the DFS staining pattern. ANA analysis was performed in a total of 964/1016 (94.88%) CTD patients and 44 (4.56%) of these positive for anti-DFS70. The correlation coefficient showed good correlations between the DFS pattern staining and anti-DFS70 antibody positivity (r=+0.773, p<0.001).

Conclusions: Anti-DFS70-positives have a low rate of CTD. A low anti-DFS70 positivity rate was observed in patients with CTD. As such, it can be considered that anti-DFS70 does not predict CTD or even excludes it.
The frailty phenotype in hemodialysis patients and its association with biochemical markers of mineral bone disorder, inflammation and nutrition
Authors: Mutevelić-Turković Alma , Resić Halima , Roljić Badema Čengić , Dervišević Amela , Bećiragić Amela 
Published: August 2021

Abstract

Introduction: Frailty is a state of increased vulnerability to physical stressors. It is common in patients with end-stage renal disease (ESRD) who are on hemodialysis (HD).
The aim of this study was to analyze the presence of frailty phenotype among HD patients and to evaluate their interrelationship with different biochemical markers.

Methods: For the frailty assessment the Frailty Phenotype by Fried et al. was used, where frailty was reported if three of the following criteria were met: unintentional weight loss, self-reported exhaustion, weakness, slow walking speed and low physical activity. From 281 HD patients, 126 patients were frail, 58 were pre-frail (two criteria were met) and the rest of the study population were robust (97 patients). BMI was calculated for all patients and venous blood samples were taken to determine laboratory parameters for bone alkaline phosphatase (BAP), phosphate (P), potassium (K), C-reactive protein (CRP) and albumin.

Results: Patients who were on HD longer than 60 months have more characters of frailty. (p=0.019). A statistically significant positive correlations between frailty score and BAP (rho = 0.189; p = 0.001), and CRP (rho = 0.233; p < 0.001) were observed, and significant negative correlations between frailty score and albumin (rho = - 0.218; p < 0.001) and K (rho = - 0.198; p = 0.001).

Conclusions: The associations of frailty with markers of mineral bone disorder, inflammation and nutrition indicate the importance of these parameters in the indirect assessment of the frailty phenotype in HD patients.
A practical review of diabetes mellitus type 2 treatment in primary care
Authors: Call Justin T. , Cortés Pedro , Harris Dana M. 
Published: August 2021

Abstract
The treatment of diabetes mellitus type 2 (DM2) is becoming more complex as new medications are approved. Primary care providers must maintain their medical knowledge on emerging medications for best patient care. This review simplifies the non-insulin treatments of diabetes with an emphasis on the cardio-renal protectants, sodium-glucose cotransporter 2 (SGLT-2) inhibitors and glucagon-like peptide 1 receptor agonists (GLP-1).
Lupus-related protein-losing enteropathy associated with pseudo-pseudo Meigs’ syndrome and successfully treated with hydroxychloroquine
Authors: Horino Taro , Ogasawara Masami , Kashio Takeshi , Inotani Satoshi , Ishihara Masayuki , Ohnishi Hiroshi , Komori Masahiro , Ichii Osamu , Terada Yoshio 
Published: August 2021

Abstract
We herein report the first case of lupus-related protein-losing enteropathy associated with pseudo-pseudo Meigs’ syndrome. Lupus-related protein-losing enteropathy and pseudo-pseudo Meigs’ syndrome are extremely rare complications in patients with systemic lupus erythematosus, Both have a similar clinical course characterized by producing marked ascites, and respond to steroids in typical cases. However, in our case, steroid monotherapy was inadequate and the addition of hydroxychloroquine was effective for their treatment. Furthermore, no reports have previously confirmed elevated CA 125 levels with lupus-related protein-losing enteropathy or increased 99mTc-HSA activity with pseudo-pseudo Meigs’ syndrome. In addition, we are the first to report an evaluation of the histopathology of lupus-related protein-losing enteropathy. Previously reported cases have been described as being caused by either pseudo-Meigs’s syndrome or lupus-related protein-losing enteropathy as the cause of the rare pathology that causes marked pleural effusion and ascites in patients with systemic lupus erythematosus, but it has not been evaluated whether the other is co-occurring. Our case highlights that there is a potential case of overlapping lupus-related protein-losing enteropathy and pseudo-Pseudo-Meigs’s syndrome. Furthermore, it is possible that patients with marked ascites with elevated CA 125 levels were mistakenly diagnosed with Meigs’s syndrome or pseudo-Meigs’s syndrome associated with malignant or benign ovarian tumors and underwent surgery. Clinicians should not forget SLE with pseudo-Pseudo-Meigs’s syndrome as one of the differential diagnoses for marked ascites with elevated CA 125 levels.
Cancer - dysregulation of the cell cycle and transduction of cascade signals
Authors: Madaminov Akhmad , Khasanov Akbar , Khatamov Shuhrat , Abdurakhmonov Otabek , Amonov Anvar , Shukurov Zohir , Khudayorov Murod , Bekmirzaev Rahim , Nishonboev Latif 
Published: August 2021

Abstract
According to scientific data, cancer is a very ancient disease, and along with the perfection of humanity it becomes more progressive. The development of technologies that detect molecular changes in the pathogenesis and subsequent development of carcinogenesis has led to the beginning of a new era in oncology. The cell cycle is tightly controlled by a group of protein kinases, including cyclin and cyclin-dependent kinases. These events occur in a strictly regulated time sequence supported by consistent restriction points. p53, p21, p16, retinoblastoma (and other proteins), cyclins and cyclin-related kinases repair DNA before the cell cycle enters the phase of synthesis and mitosis. Loss of regulatory activity of p53 and pRB, stable activation of E2F stimulates uncontrolled cell proliferation, leading to neoplastic cell growth. The Ras/Raf/MEK/ERK signalling pathway is also a complex network of sequentially activated proteins that play a major role in the onset and development of cancer. It can regulate not only the biological functions, such as cell proliferation, cycle regulation, cell differentiation, apoptosis and tissue formation, but it is also associated with tumor development. Stable mutations in the genome or defects in the epigenome lead to dysregulation in the normal biological cycle of the cell, underlying DNA chain damage or dysfunction in the control system, determined by various types of carcinogenic factors, both known and unknown.
Are Lactobacillus Bulgaricus and Bacillus Calmette-Guérin vaccine suitable for patient protection against SARS-CoV-2 infection?
Authors: Avramov Toma , Vicheva Dilyana , Manolova Antoaneta 
Published: August 2021

Abstract
Before COVID-19 infection caused the global pandemic in 2020, coronavirus diseases were mainly of veterinary interest. This pandemic necessitated the development of protective and therapeutic measures against the spread of SARS-CoV-2. Foods containing representatives of the genus Lactobacillus are an integral part of the daily menu of the Bulgarian people. Our hypothesis is based on studies examining its potential for competitive inhibition of viruses and bacteria by attachment to the surface of enterocytes.
Bacillus Calmette-Guérin (BCG) is an integral part of the vaccination calendar in the Republic of Bulgaria. In the literature, many clinical studies show that the administration of BCG vaccine limits the SARS-CoV-2 antigens and, consequently, is able to induce protection for COVID-19, by activating the specific, innate immune system.
The lack of definitively approved treatment necessitates finding ways to limit the spread of COVID-19 until final drug approval. We believe that the use of dietary components in the context of competitive inhibition and the vaccination schedule for protection in coronavirus-related diseases is applicable. We hypothesize that Lactobacillus and BCG may play a protective effect against SARS-CoV-2 infection alone or in combination in healthy individuals.
Foreign body of endodontic origin in the maxillary sinus
Authors: Preda Mihai , Sarafoleanu Codrut 
Published: August 2021

Abstract
Displacement of foreign bodies into the maxillary sinus is still a rare pathology, but the incidence is increasing continuously with the development of dental procedures. Most cases of foreign bodies are associated with dental procedures. These can be of varying natures, such as dental implants, fractured teeth roots, endodontic materials and tools, dental burs, dental impression materials or dental fillings materials. Less frequent are the foreign bodies of non-dental origin, which are related to facial injuries in accidents or assaults. The diagnosis is based on careful clinical and radiological examinations. Foreign bodies should be diagnosed and treated on time in order to prevent complications, mainly acute or chronic rhinosinusitis.
In this article, we review the main characteristics regarding the incidence, etiology, diagnosis and treatment options – endoscopic and an external approach for the removal of a displaced foreign body into the maxillary sinus. Also, we present our personal experience and treatment options, highlighting the importance of pre-operative evaluation, proper imaging assessment, adequate access and visibility and adequate surgical technique, in order to prevent later sinonasal infectious complications.
The influence of vocal rehabilitation methods on communication in patients with total laryngectomy
Authors: Kiss Beáta , Casautanu Boris , Neagos Adriana 
Published: August 2021

Abstract

BACKGROUND. Considering the problematic social integration after total laryngectomy, evaluation of communicational aptitudes of patients after the surgical intervention is necessary in order to optimize their vocal rehabilitation process.

MATERIAL AND METHODS. A prospective clinical study was conducted on 24 randomly selected patients of the Otolaryngology Clinic of Targu Mures County Emergency Clinical Hospital that underwent total laryngectomy. We adapted and implemented the questionnaire for Self-Evaluation of Communication Experiences after Laryngectomy – SECEL. Three groups of patients were created: the first containing those with voice prosthesis, the second those using electrolarynx and esophageal voice, and the third with no rehabilitation. We used the Kruskal-Wallis test for the statistical analysis of the results.

RESULTS. The mean age of the patients included in our study group was 63 years (+/− 7.56 SD). 95.83% of the participants were male. 79.16% were married. The majority (87.50%) of patients were retired. In 75% of cases, 0 to 5 years have passed since the surgery. 75% reported diminished communication after surgery. The test used to determine if significant differences were present between the examined groups showed a p-value of 0.1329 (total scores), p-value of 0.3244 (the first score of SECEL), p-value = 0.6004 (the second score of SECEL) and a p-value of 0.0613 (the third score of SECEL). Given that p was higher than 0.05, the null hypotheses could not be rejected. The patients who underwent rehabilitation by tracheoesophageal prosthesis showed the best results in all tested categories.

CONCLUSION. The SECEL questionnaire adapted in Romanian language could be used as a valid screening instrument in order to improve voice rehabilitation, but it needs further testing.
Pneumosinus dilatans associated with infantile cerebral palsy and nasal polyposis: Case report
Authors: Lugo-Machado Juan Antonio , Enriquez Luis Manuel Justo , Pérez Martha Lucía Gutiérrez , Niño Natalia Barreto , Contreras David Fernando Acevedo , Bastos Luis Alfonso Paredes , Marquez Fernanda Verena Barragan , Lizarraga Lorenz Lizarraga , Rodriguez Martha Jeaneth Jimenez , Hernández Dalia Iveth Yocupicio 
Published: August 2021

Abstract
Pneumosinus dilatans is a rare disease characterized by air-filled expansion of a paranasal sinus. Approximately 134 cases are reported in the literature, but not only one associated with infantile cerebral palsy (ICP) and nasal polyposis. We herein present this case report aimed to further characterize this uncommon condition: a 28-year-old female diagnosed with infantile cerebral palsy and nasal polyposis, in whom the cranio-facial CT scan revealed the association of a pneumosinus dilatans involving the frontal sinus. The patient is currently undergoing a protocol for endoscopic surgery of the nose and paranasal sinuses.
Descending mediastinitis secondary to deep neck abscess in a healthy patient: Case report
Authors: Lugo-Machado Juan Antonio , Pérez Martha Lucía Gutiérrez , Quintana Óscar Said Rodríguez , Márquez Fernanda Verena Barragán , Pinelli Regina Jacobo , Lizárraga Carolina Verde , Alvarado Alejandra Pineda 
Published: August 2021

Abstract
Necrotizing descending mediastinitis is an emergency which can be fatal in most cases. 80% to 85% of patients who develop descending necrotizing mediastinitis are young, previously healthy persons. We present the case of a healthy patient who, after a neck abscess, developed descending necrotizing mediastinitis complicated by atypical interstitial pneumonia.
The effects of microwave radiation generated by mobile phones on the tear film
Authors: Gajta Aurora , Jurca Alexandra Maria , Stănilă Adriana , Stănilă Dan 
Published: August 2021

Abstract
Electromagnetic radiation (ER) emitted by mobile phones and other modern devices has potentially harmful effects on ocular tissue. Their effects on the eye surface and tear film are little known so far. The aim of this paper was to investigate the effects of ER emitted by the phone mobile on the tear film. For this study, we selected a total of 50 subjects, young, healthy, without chronic treatment, who are not contact lens wearers and who have no history of ophthalmic surgery. Schirmer I test, tear pH and tear ferning test (TFT) were performed on all subjects before (“-pre”) being exposed to ER emitted by the mobile phone and after (“-post”) exposure for 5 minutes, the pH and TFT of the tears were performed. Following the analysis of the obtained results, we found that there are significant changes in tear quality and increased tear pH, which over time can lead to tear film instability, damage to the eye surface and the appearance of dry eye syndrome.
The Expression of miR-155-5p and Local Matrix Gla Protein in Meningiomas
Authors: Gheorghe Simona Roxana , Marian Cătălin , Tătăranu Ligia Gabriela , Dricu Anica , Vermeer Cees , Silaghi Ciprian Nicolae , Crăciun Alexandra Marioara 
Published: August 2021

Abstract
Meningiomas are classified by the World Health Organization (WHO) in three grades, based on morphological features. Independent of this grading, the presence of calcification in meningiomas influences their growth rate. The messenger RNA of matrix Gla protein (MGP), an extra-hepatic protein with different conformations involved in the homeostasis of ectopic calcification has been found in meningiomas and was shown to be regulated in breast cancer by miR-155-5p, a specific micro RNA. Therefore, we investigated the expression of miR-155-5p and its relationship with local MGP conformations in different grade meningiomas. According to the WHO classification, our 41 samples of meningiomas were stratified in groups WHO I and WHO II. Using real time polymerase chain reaction, we observed a higher miR-155-5p expression in group WHO I versus group WHO II [with a fold change (FC) of 3.83, p=0.027)]. Moreover, the expression of miR-155-5p was higher in calcified tumors compared to non-calcified tumors in all samples (FC=3.01, p=0.047) and in group WHO I (FC=3.65, p=0.048). Utilizing immunohistochemistry, we determined the concurrent presence of all MGP conformations in calcified meningiomas. This study was the first to establish higher miR-155-5p expression in grade WHO I and calcified meningiomas, which could improve molecular classification and targeted therapy and also the presence of all MGP conformations in calcified meningiomas, confirming the existence of an anti-calcification mechanism in meningiomas..
Lupus anticoagulant in children – a confounding factor in diagnosis and targeted therapy
Authors: Jinca Cristian , Serban Margit , Ursu Emilia , Pascalau Nicoleta Anamaria , Belei Oana , Savescu Delia , Lelik Mihaela , Munteanu Andrei Ioan , Tiede Andreas , Arghirescu Smaranda 
Published: August 2021

Abstract

Introduction: Lupus anticoagulant (LAC) belongs to a heterogeneous group of antibodies directed against negatively charged phospholipid-binding proteins, inhibiting phospholipid-dependent reactions. We assessed the frequency, etiological background, clinical and biological expression as well as the appropriate management and outcome of LAC in a pediatric population.

Patients and methods: We included 19 pediatric patients diagnosed with a positive LAC test during a period of 1 year. LAC detection was carried out according to the ISTH/SCC guidelines 2012. Coagulometric assays were performed in order to check for coagulation factor activities. The presence of specific inhibitors has been tested by the Bethesda assay.

Results: LAC was positive in 0.4% of the patients monitored for increased activated partial thromboplastin time (aPTT) during the study period of 1 year. In contrast to the asymptomatic clinical image presented by the majority of our patients, the biological picture was dominated by an elevated aPTT (79 %), the aPTT ratio correlating significantly with the strength of LAC. In 58 % of the patients LAC became negative within 12 weeks, in another 4 (21%) patients within 20 weeks, whereas in 4 (21%) patients LAC remained positive throughout the follow-up.

Conclusion: Albeit usually innocent in asymptomatic patients, LAC needs to be seriously taken into consideration from the diagnostic point of view in order to avoid dangerous therapeutic attitudes..
Insights into Innate Immune Response Against SARS-CoV-2 Infection
Authors: Huțanu Adina , Georgescu Anca Meda , Andrejkovits Akos Vince , Au William , Dobreanu Minodora 
Published: August 2021

Abstract
The innate immune system is mandatory for the activation of antiviral host defense and eradication of the infection. In this regard, dendritic cells, natural killer cells, macrophages, neutrophils representing the cellular component, and cytokines, interferons, complement or Toll-Like Receptors, representing the mediators of unspecific response act together for both activation of the adaptive immune response and viral clearance. Of great importance is the proper functioning of the innate immune response from the very beginning. For instance, in the early stages of viral infection, the defective interferon response leads to uncontrolled viral replication and pathogen evasion, while hypersecretion during the later stages of infection generates hyperinflammation. This cascade activation of systemic inflammation culminates with cytokine storm syndrome and hypercoagulability state, due to a close interconnection between them. Thus an unbalanced reaction, either under- or over- stimulation of the innate immune system will lead to an uncoordinated response and unfavorable disease outcomes. Since both cellular and humoral factors are involved in the time-course of the innate immune response, in this review we aimed to address their gradual involvement in the antiviral response with emphasis on key steps in SARS-CoV-2 infection.
Deity, love, punishment, rage, and mythonyms from head to toes. A brief history of some medical terms
Authors: Naznean Adrian 
Published: August 2021

AbstractAlthough it is undoubtful that today’s Medical English is rooted in Greek and Latin, it is particularly interesting that figures from Greek mythology are the roots of words to describe conditions, body parts, feelings, substances, etc. While there are numerous medical terms that are derived from the names of Greek mythological figures, this paper will only investigate words ranging from A to H and will try to justify the relationship between the concepts and the choice of terminology.