bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related quality of life after posterior vertebral column resection in children: comparison with healthy controls
Authors: Syvänen Johanna , Helenius Linda , Raitio Arimatias , Gerdhem Paul , Diarbakerli Elias , Helenius Ilkka 
Published: June 2021

Abstract
Purpose
Vertebral column resection (VCR) is a technique performed for short, angular spinal deformities. Several studies have reported good radiographic results with VCR regarding curve correction. However, only a few studies have reported the impact of this technique on the health-related quality-of-life measures (HRQoL).

Methods
A single surgeon series of 27 consecutive children (mean age at surgery 12.3 years, range 1.1–20.7 years) undergoing posterior VCR with a minimum of 2-year follow-up. The comparison was made to age- and gender-matched healthy controls. Outcome measures included Scoliosis Research Society (SRS) questionnaire both pre- and postoperatively, radiographic outcomes, and complications.

Results
The average major curve correction was 60.3% in the VCR patients. Complications were noted in 12 out of 27 (44%) of the VCR patients but all patients recovered fully during follow-up. The SRS pain domain scores improved significantly after VCR (p = 0.0002). The SRS total and domain scores were significantly lower than in the healthy controls especially in the self-image and function domains, but the pain and activity domains improved from preoperative to similar level than in the control group.

Conclusions
HRQoL showed significant improvement in pain scores despite 44% risk of transient complications after VCR in pediatric patients. This health-related quality-of-life improvement remained at a significantly lower level than in the healthy control group.

Level of Evidence
Therapeutic Level III.
Numerical estimates of risk factors contingent on credit ratings
Authors: Gärtner T. , Kaniovski S. , Kaniovski Y. 
Published: June 2021

AbstractAssuming a favorable or an adverse outcome for every combination of a credit class and an industry sector, a binary string, termed as a macroeconomic scenario, is considered. Given historical transition counts and a model for dependence among credit-rating migrations, a probability is assigned to each of the scenarios by maximizing a likelihood function. Applications of this distribution in financial risk analysis are suggested. Two classifications are considered: 7 non-default credit classes with 6 industry sectors and 2 non-default credit classes with 12 industry sectors. We propose a heuristic algorithm for solving the corresponding maximization problems of combinatorial complexity. Probabilities and correlations characterizing riskiness of random events involving several industry sectors and credit classes are reported.
Evaluation of accelerated motion-compensated 3d water/fat late gadolinium enhanced MR for atrial wall imaging
Authors: Munoz Camila , Sim Iain , Neji Radhouene , Kunze Karl P. , Masci Pier-Giorgio , Schmidt Michaela , O’Neill Mark , Williams Steven , Botnar René M. , Prieto Claudia 
Published: June 2021

Abstract
Objective
3D late gadolinium enhancement (LGE) imaging is a promising non-invasive technique for the assessment of atrial fibrosis. However, current techniques result in prolonged and unpredictable scan times and high rates of non-diagnostic images. The purpose of this study was to compare the performance of a recently proposed accelerated respiratory motion-compensated 3D water/fat LGE technique with conventional 3D LGE for atrial wall imaging.

Materials and methods
18 patients (age: 55.7±17.1 years) with atrial fibrillation underwent conventional diaphragmatic navigator gated inversion recovery (IR)-prepared 3D LGE (dNAV) and proposed image-navigator motion-corrected water/fat IR-prepared 3D LGE (iNAV) imaging. Images were assessed for image quality and presence of fibrosis by three expert observers. The scan time for both techniques was recorded.

Results
Image quality scores were improved with the proposed compared to the conventional method (iNAV: 3.1 ± 1.0 vs. dNAV: 2.6 ± 1.0, p = 0.0012, with 1: Non-diagnostic to 4: Full diagnostic). Furthermore, scan time for the proposed method was significantly shorter with a 59% reduction is scan time (4.5 ± 1.2 min vs. 10.9 ± 3.9 min, p < 0.0001). The images acquired with the proposed method were deemed as inconclusive less frequently than the conventional images (expert 1/expert 2: 4/7 dNAV and 2/4 iNAV images inconclusive).

Discussion
The motion-compensated water/fat LGE method enables atrial wall imaging with diagnostic quality comparable to the current conventional approach with a significantly shorter scan of about 5 min.
Density-dependent behavioural interactions influence coexistence between a native and a non-native mesopredator
Authors: Jakubavičiūtė Eglė , Candolin Ulrika 
Published: June 2021

AbstractThe invasion of non-native species into an ecosystem can markedly alter the structure and functioning of the system. Yet, we have limited knowledge of the factors that determine invasion success. Behavioural interactions have been suggested as critical determinants of invasion success in animals, but the exact mechanisms are less well known. We investigated if density-dependent behavioural interactions could have facilitated the invasion of the shrimpPalaemon elegansinto the spawning habitat of the threespine sticklebackGasterosteus aculeatusin the Baltic Sea. This was done by manipulating the densities of the two species in mesocosms. We found the stickleback to dominate behaviourally over the shrimp through higher aggression, but that the impact on the shrimp was density-dependent; a high density of sticklebacks increased aggressive interactions, which caused the shrimps to decrease their activity and restrict their habitat use to dense vegetation, while a low density of sticklebacks had no impact on the distribution and activity of the shrimps. The density of the shrimps had no impact on stickleback behaviour. These results suggest that the present density of the stickleback has allowed the invasion of the shrimp into the habitat. However, a current increase in stickleback abundance caused by human-induced ecological disturbances could limit the further expansion of the shrimp. Thus, our results indicate that a behavioural mechanism–density-dependent aggression–can influence invasion success and subsequent population expansion. At a broader level, our results stress the importance of considering density-dependent behavioural interactions when investigating the mechanisms behind invasion success.
Changes in colorectal cancer knowledge and screening intention among Ohio African American and Appalachian participants: The screen to save initiative
Authors: Boutsicaris Andrew S. , Fisher James L. , Gray Darrell M. , Adeyanju Toyin , Holland Jacquelin S. , Paskett Electra D. 
Published: June 2021

AbstractAfrican Americans and Appalachians experience greater incidence and mortality rates of colorectal cancer due to factors, such as reduced prevalence of screening. An educational session (the Screen to Save Initiative) was conducted to increase intent to screen for colorectal cancer among African Americans and Appalachians in Ohio. Using a community-based approach, from April to September 2017, 85 eligible participants were recruited in Franklin County and Appalachia Ohio. Participants completed a knowledge assessment on colorectal cancer before and after participating in either an educational PowerPoint session or a guided tour through an Inflatable Colon. Logistic regression models were used to determine what factors were associated with changes in colorectal cancer knowledge and intent to screen for colorectal cancer. The majority (71.79%) of participants gained knowledge about colorectal cancer after the intervention. Multivariate results showed that race (OR = 0.30; 95% CI: 0.11–0.80 for African Americans versus White participants) and intervention type (OR = 5.97; 95% CI: 1.94–18.43 for PowerPoint versus Inflatable Colon) were associated with a change in knowledge. The association between education and intent to screen was marginally statistically significant (OR = 0.42; 95% CI: 0.16–1.13 for college graduate versus not a college graduate). A change in colorectal cancer knowledge was not associated with intent to screen. Future educational interventions should be modified to increase intent to screen and screening for colorectal cancer. Further research with these modified interventions should aim to reduce disparities in CRC among underserved populations while listening to the voices of the communities.
CTRP-3 Regulates NOD1-mediated Inflammation and NOD1 Expression in Adipocytes and Adipose Tissue
Authors: Schmid Andreas , Schäffler Andreas , Karrasch Thomas 
Published: June 2021

AbstractThe anti-inflammatory adipokine CTRP-3 might affect innate immune reactions such as NOD1. The impact of CTRP-3 on NOD1-mediated inflammation in adipocytes and monocytic cells as well as on NOD1 expression was investigated. Murine 3T3-L1 pre-adipocytes and adipocytes as well as human THP-1 monocyte-like cells were co-stimulated with the synthetic NOD1 agonist Tri-DAP and recombinant CTRP-3. Gonadal adipose tissue and primary adipocytes were obtained from a murine model carrying a knockout (KO) of CTRP-3 in adipocytes but not in stroma-vascular cells. Wildtype mice with lipopolysaccharide (LPS)-induced elevated NOD1 expression were treated with CTRP-3. Secreted inflammatory cytokines in cell supernatants were measured by ELISA and mRNA levels were quantified by RT-PCR. Pro-inflammatory chemokine and cytokine secretion (MCP-1, RANTES, TNFα) was induced by NOD1 activation in adipocytes and monocyte-like cells, and MCP-1 and RANTES release was effectively inhibited by pre-incubation of cells with CTRP-3. CTRP-3 also antagonized LPS-triggered induction of NOD1 gene expression in murine adipose tissue, whereas adipocyte CTRP-3 deficiency upregulated NOD1 expression in adipose tissue. CTRP-3 is an effective antagonist of peptidoglycan-induced, NOD1-mediated inflammation and of LPS-induced NOD1 expression. Since basal NOD1 expression is increased by adipocyte CTRP-3 deficiency, there have to be also inflammation-independent mechanisms of NOD1 expression regulation by CTRP-3.
Evaluation of log P, pKa, and log D predictions from the SAMPL7 blind challenge
Authors: Bergazin Teresa Danielle , Tielker Nicolas , Zhang Yingying , Mao Junjun , Gunner M. R. , Francisco Karol , Ballatore Carlo , Kast Stefan M. , Mobley David L. 
Published: June 2021

AbstractThe Statistical Assessment of Modeling of Proteins and Ligands (SAMPL) challenges focuses the computational modeling community on areas in need of improvement for rational drug design. The SAMPL7 physical property challenge dealt with prediction of octanol-water partition coefficients and pKa for 22 compounds. The dataset was composed of a series of N-acylsulfonamides and related bioisosteres. 17 research groups participated in the log P challenge, submitting 33 blind submissions total. For the pKa challenge, 7 different groups participated, submitting 9 blind submissions in total. Overall, the accuracy of octanol-water log P predictions in the SAMPL7 challenge was lower than octanol-water log P predictions in SAMPL6, likely due to a more diverse dataset. Compared to the SAMPL6 pKa challenge, accuracy remains unchanged in SAMPL7. Interestingly, here, though macroscopic pKa values were often predicted with reasonable accuracy, there was dramatically more disagreement among participants as to which microscopic transitions produced these values (with methods often disagreeing even as to the sign of the free energy change associated with certain transitions), indicating far more work needs to be done on pKa prediction methods.
A review on the direct electroplating of polymeric materials
Authors: Augustyn Piotr , Rytlewski Piotr , Moraczewski Krzysztof , Mazurkiewicz Adam 
Published: June 2021

AbstractThis work is a review of the literature on the possibilities for electroplating of polymer materials. Methods of metalizing polymers and their composites were presented and discussed. Information from various publications on the electrical properties of polymers and polymer composites was collected and discussed. The most important results on the electroplating of conductive polymers and conductive composites were presented and compared. This work especially focuses on the electrical conductivity of polymer materials. The main focus was the efficiency of metal electrodeposition. Based on the analyzed publications, it was found that electrically deposited metal layers on conductive polymeric materials show discontinuity, considerable roughness, and different layer thickness depending on the distance from the contact electrode. The use of metal nanoparticles (AgNWs) or nickel nanoparticles (NiNPs) as a filler enables effective metallization of the polymer composite. Due to the high aspect ratio, it is possible to lower the percolation threshold with a low filler content in the polymer matrix. The presented review reveals many of the problems associated with the effectiveness of the electroplating methods. It indicates the need and direction for further research and development in the field of electroplating of polymer materials and modification of their electrical properties.
Children Fleeing Domestic Violence to Emergency Accommodations: Education Rights and Experiences
Authors: Selvik Sabreen , Thjømøe Cathrine 
Published: June 2021

AbstractDomestic violence forces many families to flee to emergency accommodations. This article focuses on children’s experiences of schooling and life at confidential addresses, and to what extent their legal right to education in the face of domestic violence is safeguarded in practice. Data were collected from interviews with 20 children aged 6–16 with multiple relocations at Norwegian refuges for abused women. Interviews were coded using the constructive approach to grounded theory. Data were analyzed using Antonovsky's theory and interpreted within the context of Norwegian and international law, examining the rights of children to education versus the legal rights of abusers. The findings indicate that children’s rights to education and a life without violence may be sacrificed in favor of due process for abusers. The article suggests concrete protective measures to help safeguard these rights, and calls on policymakers and support agencies worldwide to rethink their policies and practice.
Tenants’ residential mobility in Switzerland: the role of housing functions
Authors: Pagani Anna , Baur Ivo , Binder Claudia R. 
Published: June 2021

AbstractThe interaction between residential preferences and dwellings is a complex system whose function thus far remains insufficiently explored. In this paper, we investigate housing functions as orchestrators of households’ residential mobility in the context of Swiss rental housing. We propose a theoretical multi-step model and use survey data from 878 Swiss tenants to inspect the model’s linkages. From the statistical analysis, we firstly observe that tenants’ residential satisfaction is more likely to increase when the gap between ideal housing functions and those actually fulfilled by the current dwelling decreases. Secondly, results show that the effectiveness of an event (e.g. a job opportunity) in triggering the move is significantly related to both residential satisfaction and the functions the dwelling fulfils prior to the trigger. Thirdly, findings show that these trigger events can be grouped into three types: radical change, problem-solving and opportunity. With a medium effect size, a radical change was found to bring about the strongest change in housing functions between past and current dwellings. Lastly, in line with the hypothesis that residential preferences vary over the life course, socio-demographic characteristics and tenancy types are found to be significant explanatory variables for households’ ideal housing functions. By disentangling the complexity of the housing system, the proposed multi-step model can be used to integrate households’ preferences with supply-side constraints in agent-based model simulations, thereby contributing to fostering the provision of quality housing, i.e. dwellings able to meet the needs of current and future occupants.
A consistent model for estimating the partitioning of Am, Pu and Se in agricultural soils
Authors: Hormann Volker 
Published: June 2021

AbstractThe component additive model UNiSeCs II for simulating the physicochemical behaviour of the radionuclides americium, plutonium and selenium in agricultural soils is presented. The model is validated by estimating the distribution coefficients (Kd) of these elements measured in batch experiments from the literature. For all three elements, the resulting average relative deviations from the experimental values are smaller than a factor of 2.5. This indicates that the model has the potential to significantly improve the predictions of radioecological models that normally use tabulated Kd values from the IAEA which are known to have large uncertainties. Using UNiSeCs II, the soil solution parameters most important for the partitioning of Am, Pu and Se are identified by single parameter variations.
Bayesian optimization with safety constraints: safe and automatic parameter tuning in robotics
Authors: Berkenkamp Felix , Krause Andreas , Schoellig Angela P. 
Published: June 2021

AbstractSelecting the right tuning parameters for algorithms is a pravelent problem in machine learning that can significantly affect the performance of algorithms. Data-efficient optimization algorithms, such as Bayesian optimization, have been used to automate this process. During experiments on real-world systems such as robotic platforms these methods can evaluate unsafe parameters that lead to safety-critical system failures and can destroy the system. Recently, a safe Bayesian optimization algorithm, called SafeOpt, has been developed, which guarantees that the performance of the system never falls below a critical value; that is, safety is defined based on the performance function. However, coupling performance and safety is often not desirable in practice, since they are often opposing objectives. In this paper, we present a generalized algorithm that allows for multiple safety constraints separate from the objective. Given an initial set of safe parameters, the algorithm maximizes performance but only evaluates parameters that satisfy safety for all constraints with high probability. To this end, it carefully explores the parameter space by exploiting regularity assumptions in terms of a Gaussian process prior. Moreover, we show how context variables can be used to safely transfer knowledge to new situations and tasks. We provide a theoretical analysis and demonstrate that the proposed algorithm enables fast, automatic, and safe optimization of tuning parameters in experiments on a quadrotor vehicle.
The Most Social of Maladies: Re-Thinking the History of Psychiatry From the Edges of Empire
Authors: Edington Claire 
Published: June 2021

AbstractThis paper argues that the colonial experience was never just “out there” but was a constitutive feature of the global development of psychiatry and, indeed, of social medicine itself. I show how regional knowledge about psychiatry, produced in scientific exchanges across colonial Southeast Asia over four decades and culminating with the 1937 Bandung Conference, became part of new international approaches to health care in rural areas, and later, in developing nations. In particular, I discuss how the embrace of the agricultural colony as a solution to the problem of asylum overcrowding occurred at the same moment that colonial public health experts and officials were moving away from expensive, technocratic fixes to address indigenous health needs. Yet in the search for alternatives to institutionalized care, including forms of family and community support, colonial psychiatrists were increasingly drawn into unpredictable and unwieldy networks of care and economy. Drawing on research from Vietnam, this paper decenters the asylum so as to recast the history of colonial and postcolonial psychiatry as integral to the history of social medicine and global health. The paper then returns to Bandung in 1955, the site of another famous meeting in the history of Third World solidarity, to consider how the embrace of the “Bandung spirit” may provide new avenues for decolonizing the history of colonial and postcolonial psychiatry.
Atherothrombosis model by silencing of protein C in APOE*3-Leiden.CETP transgenic mice
Authors: Jongejan Yvonne K. , Eikenboom Jeroen C. J. , Gijbels Marion J. J. , Berbée Jimmy F. P. , van Vlijmen Bart J. M. 
Published: June 2021

AbstractMurine atherosclerosis models are key for investigation of atherosclerosis pathophysiology and drug development. However, they do not feature spontaneous atherothrombosis as a final stage of atherosclerosis. Transgenic mice expressing both the human mutant apolipoprotein E form APOE*3-Leiden and human cholesteryl ester transfer protein (CETP), i.e. APOE*3-Leiden.CETP mice, feature a moderate hyperlipoproteinemia and atherosclerosis phenotype. In contrast to apolipoprotein E deficient (Apoeˉ/ˉ) mice, APOE*3-Leiden.CETP mice respond well to lipid-lowering and anti-atherosclerotic drugs. The aim of the study was to investigate whether silencing of anticoagulant Protein C (Proc) allows APOE*3-Leiden.CETP mice to feature thrombosis as a final stage of atherosclerosis. Female APOE*3-Leiden.CETP mice were fed a Western-type diet to induce advanced atherosclerosis, followed by an injection with a small interfering RNA targeting Proc (siProc). Presence of atherosclerosis and atherothrombosis was determined by histologic analysis of the aortic root. Atherosclerosis severity in the aortic root area of APOE*3-Leiden.CETP mice varied from type “0” (no lesions) to type “V” lesions (advanced and complex lesions). Atherothrombosis following siProc injection was observed for 4 out of 21 APOE*3-Leiden.CETP mice (19% incidence). The atherothrombosis presented as large, organized, fibrin- and leukocyte-rich thrombi on top of advanced (type “V”) atherosclerotic plaques in the aortic root. This atherothrombosis was comparable in appearance and incidence as previously reported for Apoeˉ/ˉ mice with a more severe atherosclerosis (19% incidence). APOE*3-Leiden.CETP mice with modest hyperlipidemia and atherosclerosis can develop atherothrombosis upon transient Proc-silencing. This further extends the use of these mice as a test model for lipid-lowering and anti-atherosclerotic drugs.
Rayleigh–Bénard Instability of an Ellis Fluid Saturating a Porous Medium
Authors: Celli Michele , Barletta Antonio , Brandão Pedro V. 
Published: June 2021

AbstractThe Ellis model describes the apparent viscosity of a shear–thinning fluid with no singularity in the limit of a vanishingly small shear stress. In particular, this model matches the Newtonian behaviour when the shear stresses are very small. The emergence of the Rayleigh–Bénard instability is studied when a horizontal pressure gradient, yielding a basic throughflow, is prescribed in a horizontal porous layer. The threshold conditions for the linear instability of this system are obtained both analytically and numerically. In the case of a negligible flow rate, the onset of the instability occurs for the same parametric conditions reported in the literature for a Newtonian fluid saturating a porous medium. On the other hand, when high flow rates are considered, a negligibly small temperature difference imposed across the horizontal boundaries is sufficient to trigger the convective instability.