bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐Point Observation of Hiss Emerging From Lightning Whistlers
Authors: Santolík Ondřej , Kolmašová Ivana , Pickett Jolene S. , Gurnett Donald A. 
Published: November 2021

AbstractWe analyze continuous multi‐point measurements of electromagnetic field waveforms onboard the Cluster spacecraft in order to contribute to the discussion on sources of plasmaspheric hiss, known as a shaping agent for the Earth radiation belts. In our case study we aim at finding sources of hiss observed close to the geomagnetic equator in the outer plasmasphere on the dayside. We find hiss to be triggered from whistlers of different spectral properties. Whistlers with the lowest observed dispersion arrive to different spacecraft with time delays indicating their origin in the northern hemisphere. Positions of source lightning discharges are then found using the time coincidences with the Word Wide Lightning Location Network data from three active thunderstorm regions in Europe. We find that subionospheric propagation of lightning atmospherics is necessary to explain the observations. Geographic locations of their ionospheric exit points then determine spectral properties of resulting unducted whistlers and triggered hiss. By this well documented chain of events starting with a lightning discharge in the atmosphere we confirm that magnetospherically reflecting whistlers and hiss triggered from them are among possible sources of plasmaspheric hiss.
Simultaneous UV Images and High‐Latitude Particle and Field Measurements During an Auroral Dawn Storm at Jupiter
Authors: Ebert R. W. , Greathouse T. K. , Clark G. , Hue V. , Allegrini F. , Bagenal F. , Bolton S. J. , Bonfond B. , Connerney J. E. P. , Gladstone G. R. , Imai M. , Kotsiaros S. , Kurth W. S. , Levin S. , Louarn P. , Mauk B. H. , McComas D. J. , Paranicas C. , Sulaiman A. H. , Szalay J. R. , Thomsen M. F. , Wilson R. J. 
Published: November 2021

AbstractWe present multi‐instrument Juno observations on day‐of‐year 86, 2017 that link particles and fields in Jupiter's polar magnetosphere to transient UV emissions in Jupiter's northern auroral region known as dawn storms. Juno ranged from 42°N to 51°N in magnetic latitude and 5.8–7.8 Jovian radii (1 RJ = 71,492 km) during this period. These dawn storm emissions consisted of two separate, elongated structures which extended into the nightside, rotated with the planet, had enhanced brightness (up to at least 1.4 megaRayleigh) and high color ratios. The color ratio is a proxy for the atmospheric penetration depth and therefore the energy of the electrons that produce the UV emissions. Juno observed electrons and ions on magnetic field lines mapping to these emissions. The electrons were primarily field‐aligned, bidirectional, and, at times, exhibited sudden intensity decreases below ∼10 keV coincident with intensity enhancements up to energies of ∼1,000 keV, consistent with the high color ratio observations. The more energetic electron distributions had characteristic energies of ∼160–280 keV and downward energy fluxes (∼70–135 mW m−2) that were a significant fraction needed to produce the UV emissions for this event. Magnetic field perturbations up to ∼0.7% of the local magnetic field showing evidence of upward and downward field‐aligned currents, whistler mode waves, and broadband kilometric radio emissions were also observed along Juno's trajectory during this time frame. These high‐latitude observations show similarities to those in the equatorial magnetosphere associated with dynamics processes such as interchange events, plasma injections, and/or tail reconnection.
Ionospheric Plasma Vertical Drift and Zonal Wind Variations Cause Unusual Evolution of EPBs During a Geomagnetically Quiet Night
Authors: Wu Kun , Xu Jiyao , Zhu Yajun , Yuan Wei 
Published: November 2021

AbstractPrevious studies show equatorial plasma bubbles (EPBs) mainly occur after sunset and usually drift from west to east. In this work, two EPBs occurred after midnight and lasted to sunrise, and were observed by multi‐instruments (two all‐sky imagers (ASIs), global positioning system, Swarm satellite, and a digisonde) during a geomagnetically quiet night of December 18–19, 2018. Our observations also show that plasma depletion structure (PDS) also occurred at that night. EPBs occurred in the region of PDS and showed a special evolution process during the night. Those PDS gradually disappeared with time, but strip‐like EPBs remained clearly in airglow images. Near sunrise, new PDS appeared to merge with those EPBs to form large PDS. Meanwhile, EPBs showed different zonal drifts within a very narrow longitudinal zone (∼2°). One EPB remained stationary while the other showed a small eastward drift. These results are different from post‐sunset EPBs in previous studies. During the lifetime of those ionospheric plasma irregularities, upward and downward motion of the peak height and virtual height of the ionospheric F region was observed by a digisonde, which indicates that the evolution of EPBs should be related to the vertical drift of ionospheric plasma. Besides, based Thermosphere‐Ionosphere‐Electrodynamics General Circulation Model (TIE‐GCM) simulations, we suggest the different zonal drifts of those EPBs might related to plasma zonal drifts caused by zonal winds.
Post‐20 ka Earthquake Scarps Along NE‐Tibet's Qilian Shan Frontal Thrust: Multi‐Millennial Return, ∼Characteristic Co‐Seismic Slip, and Geological Rupture Control
Authors: Li Zhanfei , Xu Xiwei , Tapponnier Paul , Chen Guihua , Li Kang , Luo Jiahong , Cheng Jia , Kang Wenjun 
Published: November 2021

AbstractEarthquake slip distributions help constrain rupture behavior and return times. Here, by combining 0.5‐m‐resolution image and topographic data interpretation with fieldwork, we quantify the co‐seismic throw distribution and rupture geometry of the 1609 Hongyazi earthquake along the Qilian Shan Fodongmiao fontal thrust (NE Tibet). We measured 396 vertical offsets across mapped geomorphic units along the thrust trace. The 1609 rupture was ∼118‐km long, with average co‐seismic throw and slip amounts of ∼1.8 ± 1.0 and ∼2.9 ± 1.4 m, respectively, consistent with a magnitude Mw of 7.4 ± 0.3. Along the ∼88‐km‐long western stretch of the thrust, our data also reveal five distinct clusters with peak cumulative throws (∼4.9, 9.3, 13.8, 18.0, and 22.2 m), implying older ruptures with nearly characteristic slip during five Mw ∼ 7.6–7.8 events, three of which were also identified in trenches. Two of these earthquakes ruptured the entire thrust, while three mainly broke the western and middle segments. The thrust geometry and segmentation are influenced by geological inheritance. The middle segment emplaces Silurian granites atop Quaternary alluvium, which may account for its irregularly cusped trace, and favor rupturing during large, Mw ∼7.8 events with multi‐millennium (∼3.7 +0.5/−2.2 ka) return times. Since ∼20 ka, the Fodongmiao Thrust has kept shortening and uplifting Tibet's northeastern boundary at steady rates of ∼1.4 and 1.1 mm/a, respectively. The remaining oblique component of convergence across the ∼800‐km‐long pushup between the Altyn Tagh and Haiyuan faults is absorbed by slip partitioning along the left‐lateral Changma and Lenglongling faults.
A Reduced Order Approach for Probabilistic Inversions of 3D Magnetotelluric Data II: Joint Inversion of MT and Surface‐Wave Data
Authors: Manassero M. C. , Afonso J. C. , Zyserman F. I. , Jones A. G. , Zlotnik S. , Fomin I. 
Published: November 2021

AbstractJoint probabilistic inversions of magnetotelluric (MT) and seismic data have great potential for imaging the thermochemical structure of the lithosphere as well as mapping fluid/melt pathways and regions of mantle metasomatism. In this contribution, we present a novel probabilistic (Bayesian) joint inversion scheme for 3D MT and surface‐wave dispersion data particularly designed for large‐scale lithospheric studies. The approach makes use of a recently developed strategy for fast solutions of the 3D MT forward problem (Manassero et al., 2020,https://doi.org/10.1093/gji/ggaa415) and combines it with adaptive Markov chain Monte Carlo (MCMC) algorithms and parallel‐in‐parallel strategies to achieve extremely efficient simulations. To demonstrate the feasibility, benefits and performance of our joint inversion method for imaging the temperature and conductivity structures of the lithosphere, we apply it to two numerical examples of increasing complexity. The inversion approach presented here is timely and will be useful in the joint analysis of MT and surface wave data that are being collected in many parts of the world. This approach also opens up new avenues for the study of trans‐lithospheric and trans‐crustal magmatic systems, the detection of metasomatized mantle, and the incorporation of MT into multi‐observable inversions for the physical state of the Earth's interior.
Meridional Eddy Heat Transport Variability in the Surface Mixed Layer of the Atlantic Ocean
Authors: Müller Vasco , Melnichenko Oleg 
Published: November 2021

AbstractWe analyze the interannual variability and trends of the eddy heat transport (EHT) in the surface mixed layer of the Atlantic Ocean from covariances of sea surface temperature (SST) and geostrophic velocities from satellite observations between 1993 and 2018. The EHT is largest along the path of the Gulf Stream in the Northern Hemisphere and the vicinity of the Agulhas Retroflection and Argentine basin in the Southern Hemisphere. On average, meridional EHT in the mixed layer leads to a divergence of heat away from the subtropics in both hemispheres toward the equator and higher latitudes. Depending on latitude, the divergence of the EHT accounts for around 1%–5% of the atmospheric net surface heat flux, but reaches as much as 20% for certain regions. The EHT can be linked to eddy kinetic energy (EKE) and meridional SST gradients using mixing length hypothesis, but the variability of EKE and SST gradients are not enough to capture local EHT variability. For different latitudes, the EHT shows different behavior over time, with a strong increase in northward EHT in the Gulf Stream region, and a decadal oscillation of poleward EHT in the tropical and subtropical regions. This oscillation on larger scales is highly correlated with spatially averaged EKE and the large‐scale SST gradients. A comparison with climate indices indicates a relation to Atlantic climate variability, especially the meridional modes of the Tropical Atlantic Variability and the North Atlantic Oscillation (NAO).
Two‐Dimensional Striking Distance of Lightning Flashes to a Cluster of Tall Buildings in Guangzhou
Authors: Qi Q. , Lyu W. , Wang D. , Wu B. , Ma Y. , Chen L. , Lyu F. , Jiang R. 
Published: November 2021

AbstractBased on the high‐speed video records of 54 lightning flashes striking on a cluster of tall buildings in Guangzhou and the return stroke peak currents provided by lightning location systems, this paper analyzed the two‐dimensional (2D) first‐return‐stroke striking distances (SD) of lightning flashes to buildings with a height ranging from 100 to 600 m. Three methods, including one proposed in this study, have been used to estimate the 2D SD. The results with different methods basically agree with each other and show that the height and the top geometry of the structure on which lightning terminates are key factors that affect the SD. The correlation between the SD and the peak return stroke current appeared very scattered, particularly in the cases when each building was considered separately. Besides, we found that: (a) the estimated 2D average initiation speed of upward connecting leader (UCL) on different buildings are similar, ranging from 4.9 to 23 × 104 m/s, with an average of 13.4 × 104 m/s; (b) about 87% (27/31) flashes that struck on buildings with simple top shape only have one upward leader observed, while for buildings with complicated top shape, only 26% (6/23) flash cases have one upward leader observed; (c) for the 36 flashes to four tall buildings with heights higher than 300 m, the 2D average speed ratio of the downward leader and the UCL is 0.74 during the last 0.1 ms before the first return stroke.
Re‐Evaluation of Large Martian Ripples in Gale Crater: Granulometric Evidence for an Impact Mechanism and Terrestrial Analogues
Authors: Gough Tyler R. , Hugenholtz Chris H. , Barchyn Thomas E. 
Published: November 2021

AbstractMars hosts three scales of superimposed aeolian bedforms: small decimeter‐scale impact ripples, large meter‐scale ripples, and dunes. The formation mechanism for large meter‐scale ripples is enigmatic and debated. This debate is largely informed by two questions: (a) Are large ripples similar to any features on Earth? and (b) Do they have the same grain size distribution as dunes and impact ripples? We address these questions using a novel digitizing approach to produce the largest known data set of Mars ripple sand grain size to date. We find a distinction between the grain size distributions of small ripples and large ripples and suggest that analogous bedforms are found on Earth. Despite an inability to perform rigorous sedimentology on Mars, results help resolve outstanding questions in bedform physics and support a hypothesis that aeolian ripples on Mars develop by a terrestrially analogous impact mechanism.
Long-term survival after intensive chemotherapy or hypomethylating agents in AML patients aged 70 years and older: a large patient data set study from European registries
Authors: Récher Christian , Röllig Christoph , Bérard Emilie , Bertoli Sarah , Dumas Pierre-Yves , Tavitian Suzanne , Kramer Michael , Serve Hubert , Bornhäuser Martin , Platzbecker Uwe , Müller-Tidow Carsten , Baldus Claudia D. , Martínez-Cuadrón David , Serrano Josefina , Martínez-Sánchez Pilar , Arbolí Eduardo Rodríguez , Gil Cristina , Bergua Juan , Bernal Teresa , de la Fuente Burguera Adolfo , Delabesse Eric , Bidet Audrey , Pigneux Arnaud , Montesinos Pau 
Published: November 2021

AbstractThe outcome of acute myeloid leukemia patients aged 70 years or older is poor. Defining the best treatment option remains controversial especially when choosing between intensive chemotherapy and hypomethylating agents. We set up a multicentric European database collecting data of 3 700 newly diagnosed acute myeloid leukemia patients ≥70 years. The primary objective was to compare overall survival in patients selected for intensive chemotherapy (n = 1199) or hypomethylating agents (n = 1073). With a median follow-up of 49.5 months, the median overall survival was 10.9 (95% CI: 9.7–11.6) and 9.2 months (95% CI: 8.3–10.2) with chemotherapy and hypomethylating agents, respectively. Complete remission or complete remission with incomplete hematologic recovery was 56.1% and 19.7% with chemotherapy and hypomethylating agents, respectively (P < 0.0001). Treatment effect on overall survival was time-dependent. The Royston and Parmar model showed that patients treated with hypomethylating agents had a significantly lower risk of death before 1.5 months of follow-up; no significant difference between 1.5 and 4.0 months, whereas patients treated with intensive chemotherapy had a significantly better overall survival from four months after start of therapy. This study shows that intensive chemotherapy remains a valuable option associated with a better long-term survival in older AML patients.
Mitotic phosphorylation of tumor suppressor DAB2IP maintains spindle assembly checkpoint and chromosomal stability through activating PLK1-Mps1 signal pathway and stabilizing mitotic checkpoint complex
Authors: Yu Lan , Lang Yue , Hsu Ching-Cheng , Chen Wei-Min , Chiang Jui-Chung , Hsieh Jer-Tsong , Story Michael D. , Shang Zeng-Fu , Chen Benjamin P. C. , Saha Debabrata 
Published: November 2021

AbstractChromosomal instability (CIN) is a driving force for cancer development. The most common causes of CIN include the dysregulation of the spindle assembly checkpoint (SAC), which is a surveillance mechanism that prevents premature chromosome separation during mitosis by targeting anaphase-promoting complex/cyclosome (APC/C). DAB2IP is frequently silenced in advanced prostate cancer (PCa) and is associated with aggressive phenotypes of PCa. Our previous study showed that DAB2IP activates PLK1 and functions in mitotic regulation. Here, we report the novel mitotic phosphorylation of DAB2IP by Cdks, which mediates DAB2IP’s interaction with PLK1 and the activation of the PLK1-Mps1 pathway. DAB2IP interacts with Cdc20 in a phosphorylation-independent manner. However, the phosphorylation of DAB2IP inhibits the ubiquitylation of Cdc20 in response to SAC, and blocks the premature release of the APC/C-MCC. The PLK1-Mps1 pathway plays an important role in mitotic checkpoint complex (MCC) assembly. It is likely that DAB2IP acts as a scaffold to aid PLK1-Mps1 in targeting Cdc20. Depletion or loss of the Cdks-mediated phosphorylation of DAB2IP destabilizes the MCC, impairs the SAC, and increases chromosome missegregation and subsequent CIN, thus contributing to tumorigenesis. Collectively, these results demonstrate the mechanism of DAB2IP in SAC regulation and provide a rationale for targeting the SAC to cause lethal CIN against DAB2IP-deficient aggressive PCa, which exhibits a weak SAC.
Evolution of HER2-positive mammary carcinoma: HER2 loss reveals claudin-low traits in cancer progression
Authors: Giusti Veronica , Ruzzi Francesca , Landuzzi Lorena , Ianzano Marianna L. , Laranga Roberta , Nironi Elena , Scalambra Laura , Nicoletti Giordano , De Giovanni Carla , Olivero Martina , Arigoni Maddalena , Calogero Raffaele , Nanni Patrizia , Palladini Arianna , Lollini Pier-Luigi 
Published: November 2021

AbstractHER2-positive breast cancers may lose HER2 expression in recurrences and metastases. In this work, we studied cell lines derived from two transgenic mammary tumors driven by human HER2 that showed different dynamics of HER2 status. MamBo89HER2stable cell line displayed high and stable HER2 expression, which was maintained upon in vivo passages, whereas MamBo43HER2labile cell line gave rise to HER2-negative tumors from which MamBo38HER2loss cell line was derived. Both low-density seeding and in vitro trastuzumab treatment of MamBo43HER2labile cells induced the loss of HER2 expression. MamBo38HER2loss cells showed a spindle-like morphology, high stemness and acquired in vivo malignancy. A comprehensive molecular profile confirmed the loss of addiction to HER2 signaling and acquisition of an EMT signature, together with increased angiogenesis and migration ability. We identified PDGFR-B among the newly expressed determinants of MamBo38HER2loss cell tumorigenic ability. Sunitinib inhibited MamBo38HER2loss tumor growth in vivo and reduced stemness and IL6 production in vitro. In conclusion, HER2-positive mammary tumors can evolve into tumors that display distinctive traits of claudin-low tumors. Our dynamic model of HER2 status can lead to the identification of new druggable targets, such as PDGFR-B, in order to counteract the resistance to HER2-targeted therapy that is caused by HER2 loss.
Emerging role of G9a in cancer stemness and promises as a therapeutic target
Authors: Haebe Joshua R. , Bergin Christopher J. , Sandouka Tamara , Benoit Yannick D. 
Published: November 2021

AbstractThe histone methyltransferase G9a is well-documented for its implication in neoplastic growth. However, recent investigations have demonstrated a key involvement of this chromatin writer in maintaining the self-renewal and tumor-initiating capacities of cancer stem cells (CSCs). Direct inhibition of G9a’s catalytic activity was reported as a promising therapeutic target in multiple preclinical studies. Yet, none of the available pharmacological inhibitors of G9a activity have shown success at the early stages of clinical testing. Here, we discuss central findings of oncogenic expression and activation of G9a in CSCs from different origins, as well as the impact of the suppression of G9a histone methyltransferase activity in such contexts. We will explore the challenges posed by direct and systemic inhibition of G9a activity in the perspective of clinical translation of documented small molecules. Finally, we will discuss recent advances in drug discovery as viable strategies to develop context-specific drugs, selectively targeting G9a in CSC populations.
Unexpected myriad of co-occurring viral strains and species in one of the most abundant and microdiverse viruses on Earth
Authors: Martinez-Hernandez Francisco , Diop Awa , Garcia-Heredia Inmaculada , Bobay Louis-Marie , Martinez-Garcia Manuel 
Published: November 2021

Abstract
Viral genetic microdiversity drives adaptation, pathogenicity, and speciation and has critical consequences for the viral-host arms race occurring at the strain and species levels, which ultimately impact microbial community structure and biogeochemical cycles. Despite the fact that most efforts have focused on viral macrodiversity, little is known about the microdiversity of ecologically important viruses on Earth. Recently, single-virus genomics discovered the putatively most abundant ocean virus in temperate and tropical waters: the uncultured dsDNA virus vSAG 37-F6 infecting Pelagibacter, the most abundant marine bacteria. In this study, we report the cooccurrence of up to ≈1,500 different viral strains (&gt;95% nucleotide identity) and ≈30 related species (80-95% nucleotide identity) in a single oceanic sample. Viral microdiversity was maintained over space and time, and most alleles were the result of synonymous mutations without any apparent adaptive benefits to cope with host translation codon bias and efficiency. Gene flow analysis used to delimitate species according to the biological species concept (BSC) revealed the impact of recombination in shaping vSAG 37-F6 virus and Pelagibacter speciation. Data demonstrated that this large viral microdiversity somehow mirrors the host species diversity since ≈50% of the 926 analyzed Pelagibacter genomes were found to belong to independent BSC species that do not significantly engage in gene flow with one another. The host range of this evolutionarily successful virus revealed that a single viral species can infect multiple Pelagibacter BSC species, indicating that this virus crosses not only formal BSC barriers but also biomes since viral ancestors are found in freshwater.
Feasibility and efficacy of salvage allogeneic stem cell transplantation in AML patients relapsing after autologous stem cell transplantation
Authors: Shumilov Evgenii , Shakhanova Inna , Flach Johanna , Schmidt Nicole , Buerki Susanne , Legros Myriam , Kronig Marie-Noëlle , Ofran Yishai , Gerull Sabine , Medinger Michael , Taleghani Behrouz Mansouri , Passweg Jakob , Halter Jörg , Bacher Ulrike , Pabst Thomas 
Published: November 2021

AbstractAutologous hematopoietic cell transplantation (HCT) is suitable for consolidation of favorable-/intermediate-risk AML patients in CR1. However, ~50% of AML patients relapse after autologous HCT, and efficacy of subsequent salvage strategies including allogeneic HCT remains unclear. We studied 123 consecutive patients with newly diagnosed AML undergoing high-dose chemotherapy (HDCT)/autologous HCT in CR1. In relapsing patients afterwards, we analyzed salvage treatments and outcomes focusing particularly on salvage allogeneic HCT. Of 123 patients, 64 (52%) relapsed after autologous HCT. Subsequently, 13 (21%) received palliative therapy, whereas 51 (79%) proceeded to salvage therapy with a curative intent. Of the 47 patients with a curative intent and who did not proceed directly to allogeneic HCT, 23 (49%) achieved CR2 or had ongoing hematologic CR1 despite molecular relapse. Finally, 30 patients (47%) received allogeneic HCT with estimated 3-year leukemia-free and overall survival rates of 33% and 43%. Hematologic remission at allogeneic HCT and lack of acute GvHD had a positive impact on OS and LFS (p < 0.05). Our study suggests that almost 80% of AML patients can undergo salvage therapy following relapse after front-line HDCT/autologous HCT. Allogeneic HCT can provide cure in one third of patients relapsing after front-line HDCT/autologous HCT.