bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review and comparison of algorithms and software for mixed-integer derivative-free optimization
Authors: Ploskas Nikolaos , Sahinidis Nikolaos V. 
Published: September 2021

AbstractThis paper reviews the literature on algorithms for solving bound-constrained mixed-integer derivative-free optimization problems and presents a systematic comparison of available implementations of these algorithms on a large collection of test problems. Thirteen derivative-free optimization solvers are compared using a test set of 267 problems. The testbed includes: (i) pure-integer and mixed-integer problems, and (ii) small, medium, and large problems covering a wide range of characteristics found in applications. We evaluate the solvers according to their ability to find a near-optimal solution, find the best solution among currently available solvers, and improve a given starting point. Computational results show that the ability of all these solvers to obtain good solutions diminishes with increasing problem size, but the solvers evaluated collectively found optimal solutions for 93% of the problems in our test set. The open-source solvers MISO and NOMAD were the best performers among all solvers tested. MISO outperformed all other solvers on large and binary problems, while NOMAD was the best performer on mixed-integer, non-binary discrete, small, and medium-sized problems.
The Spiritual Needs Questionnaire in Research and Clinical Application: a Summary of Findings
Authors: Büssing Arndt 
Published: September 2021

AbstractTo provide spiritual care, an assessment and documentation of patients´ spiritual struggles and/or their spiritual needs is required to initiate appropriate support planning processes. For that purpose, the Spiritual Needs Questionnaire (SpNQ) was developed in 2009 as an easy to apply standardized measure. The tool has so far been translated into numerous languages and is widely used as a valid and reliable instrument to assess a wide range of spiritual needs of patients with chronic diseases, elderly, adolescents, and healthy persons. Its four main factors address Religious needs, Existential needs, Inner Peace needs, and Giving/Generativity needs. Here, the main findings are summarized and discussed.
Getting On in Gotham: The Midtown Manhattan Study and Putting the “Social” in Psychiatry
Authors: Smith Matthew 
Published: September 2021

AbstractIn the spring of 1962, a series of alarming headlines greeted American newspaper readers. From “New York Living for Nuts Only” and “One in Five Here Mentally Fit” to “Scratch a New Yorker, and What Do You Find?” and “City Gets Mental Test, Results are Real Crazy,” the stories highlighted the shocking and, to some, incredible statistics that fewer than one in five (18.5%) Manhattanites had good mental health. Approximately a quarter of them had such bad mental health that they were effectively incapacitated, often unable to work or function socially. The headlines were gleaned fromMental Health in the Metropolis(1962), the first major output of the Midtown Manhattan Study, a large-scale, interdisciplinary project that surveyed the mental health of 1660 white Upper East Side residents between the ages of 20 and 59. One of the most significant social psychiatry projects to emerge following the Second World War, the Midtown Manhattan Study endeavored to “test the general hypothesis that biosocial and sociocultural factors leave imprints on mental health which are discernible when viewed from the panoramic perspective provided by a large population.” Despite initial media and academic interest, however, the Midtown Manhattan Study’s findings were soon forgotten, as American psychiatry turned its focus to individual—rather than population—psychopathology, and turned to the brain—rather than the environment—for explanations. Relying on archival sources, contemporary medical and social scientific literature, and oral history interviews, this article explains why the Midtown Manhattan Study failed to become more influential, concluding that its emphasis on the role of social isolation and poverty in mental illness should be taken more seriously today.
Phenotype and pathological significance of MCAM+ (CD146+) T cell subset in psoriatic arthritis
Authors: Raychaudhuri Smriti K. , Abria Christine , Raychaudhuri Siba P. 
Published: September 2021

AbstractBackgroundCD146 (MCAM-melanoma cell adhesion molecule) is a cell surface adhesion molecule for Laminin 411. T cells expressing MCAM are mainly responsible for IL-17 production. IL-17 secreting T helper cells (Th17 cells) are critical for the pathogenesis of psoriatic arthritis (PsA). Here we hypothesized enrichment of CD146+IL-17+memory T cells in PsA synovium and studied the association of CD146 expression and CD4+IL-17+activated memory (CD11a+CD45RO+) T cells in synovial fluid and blood of PSA, rheumatoid arthritis (RA, a positive control) and osteoarthritis (OA) patients.MethodsHi-D FACS studies were done to identify IL-17 in CD4+CD146+CD45RO+and CD8+CD146+CD45RO+T cells.ResultsWe observed that effector CD146+(MCAM+) T cells are enriched at the synovial inflammation site in PsA.ConclusionAs CD146+T cells are a key resource for IL-17 it is likely that the enrichment of these MCAM+pathologic cells are critical for the disease process of PsA.
Construction of a Review About Epigenetics for Biology Teachers and Other Non-experts
Authors: Mc Ewen Birgitta 
Published: September 2021

AbstractEpigenetics, the new research field at the cutting edge of biology research, needs to be introduced in biology education. The aim of this review is to support biology teachers and other non-experts to get an overview of the field, as a review in epigenetics has hardly been written for these groups. This review was done by finding documents describing central features of epigenetics, increasing the understanding of epigenetics’ contribution to perspectives in society, and to be a model for a review in a rapidly developing science field. As an example of societal perspectives, the old dispute about “nature” or “nurture” is discussed, epigenetics focusing on the role of “nurture’s” influence on “nature.” Consequently, epigenetics dispels biological determinism. As this review was intended to fill a gap in the literature, a theoretical framework for the construction of the review had to be invented. This was done in an iterative process during the construction of the review. Documents were searched for in the databases of ERIC, Scopus, and Web of Science, peer-reviewed, and had been published by a well-renowned publisher. The search time frame was January 2016 to December 2019, including document types books and book chapters, plus journal articles for ERIC; documents had to be written in English and published as open access. Searches were divided into pre-defined categories based on a newly performed Delphi study. Exemplar studies, which best described each category, are discussed in the light of frontline research. As implications from epigenetics are important for a variety of areas within society, the review is a contribution to the field of sociology of science, aiming to support science education at the very front of science.
Motion Magnification in Solar Imaging Data Sequences in the Sub-pixel Regime
Authors: Zhong Sihui , Duckenfield Timothy J. , Nakariakov Valery M. , Anfinogentov Sergey A. 
Published: September 2021

AbstractThe capability of the motion-magnification technique for the detection of transverse oscillations, such as kink oscillations of solar coronal loops observed with an imaging telescope, in the sub-pixel regime is investigated. The technique is applied to artificial-image sequences imitating harmonic transverse displacements of the loop, observed in the optically thin regime. Motion magnification is found to work well on the analysis of sub-pixel, $\geq 0.01$
≥
0.01
pixel oscillations, and it is characterised by linear scaling between the magnified amplitude and input amplitude. Oscillations of loops with transverse density profiles of different steepness are considered. After magnification, the original transverse profiles are preserved sufficiently well. The motion-magnification performance is found to be robust in noisy data, for coloured noise with spectral indices ranging from 0 to 3, and additional Poisson noise with a signal-to-background-noise ratio down to unity. Our findings confirm the reliability of the motion-magnification technique for applications in magnetohydrodynamic seismology of the solar corona.
Microplastic Contamination in Protected Areas of the Gulf of Venice
Authors: Mistri Michele , Scoponi Marco , Sfriso Andrea A. , Munari Cristina , Curiotto Marta , Sfriso Adriano , Orlando-Bonaca Martina , Lipej Lovrenc 
Published: September 2021

AbstractWe investigated the concentration and composition of plastics in 7 Special Areas of Conservation (SACs) from the Gulf of Venice (northern Adriatic Sea). A total of 42 sediment samples were analyzed from 21 sites from 2017 to 2018. All sites except one were found to be polluted by plastics, with density ranging between 2250 and 28.4 items kg−1. Microplastics ranged from 100 to 61.6% of the collected plastics. Fragments were more represented than filaments. The greatest plastic concentrations were generally recorded in western SACs. Identification through FT-IR spectroscopy evidenced the presence of 8 polymer types: in western SACS, the majority were low-density polymers (PE, PP, PS, and TPU), while in eastern SACs they were high-density polymers (PET, nylon, and PVC). In addition to the role of large rivers (all on the western side of the Gulf) in conveying plastics into the sea, a possible role of the cyclonic water circulation of the northern Adriatic Sea on distribution and composition of plastics along the Gulf coasts is likely.
Removal of fluoride from coke wastewater by aluminum doped chelating ion-exchange resins: a tertiary treatment
Authors: Rodríguez-Iglesias Jesús , Alcalá Lara , Megido Laura , Castrillón Leonor 
Published: September 2021

AbstractCoke wastewater is one of the most problematic industrial wastewaters, due to its large volume and complex pollutant load. In this study, ion exchange technology was investigated with the objective of reducing the fluoride content of the effluent from a coke wastewater treatment plant (26.7 mg F-/L). Two Al-doped exchange resins with chelating aminomethyl-phosphonic acid and iminodiacetic groups were assessed: Al-doped TP260 and TP207 resins, respectively. The effect of resin dosage, varying from 5 to 25 g/L, was evaluated. F- removal was within the range 57.8–89.3% and 72.0–92.1% for Al-doped TP260 and TP207, respectively. A kinetic study based on a generalized integrated Langmuir kinetic equation fitted the experimental data (R2 > 0.98). The parameters of the said kinetics met the optimal conditions for the ion exchange process, which seemed to be more favorable with Al-doped TP260 resin than with Al-doped TP207 resin, using the same resin dosage. Furthermore, the experimental data were well described (R2 > 0.98) by Langmuir and Freundlich isotherm models, in agreement with the findings of the kinetic study: the maximum sorption capacity was obtained for the Al-doped TP260 resin.
The Effect of Building Direction on Microstructure and Microhardness during Selective Laser Melting of Ti6Al4V Titanium Alloy
Authors: Palmeri D. , Buffa G. , Pollara G. , Fratini L. 
Published: September 2021

AbstractDuring the last few years, additive manufacturing has been more and more extensively used in several industries, especially in the aerospace and medical device fields, to produce Ti6Al4V titanium alloy parts. During the Selective Laser Melting (SLM) process, the heterogeneity of finished product is strictly connected to the scan strategies and the building direction. An optimal managing of the latter parameters allows to better control and defines the final mechanical and metallurgical properties of parts. Acting on the building direction it is also possible to optimize the critical support structure. In particular, more support structures are needed for the sample at 0°, while very low support are required for the sample at 90°. To study the effects of build direction on microstructure heterogeneity evolution and mechanical performances of selective laser melted Ti6Al4V parts, two build direction samples (0°, 90°) were manufactured and analyzed using optical metallographic microscope (OM) and scanning electron microscopy (SEM). Isometric microstructure reconstruction and microhardness tests were carried out in order to analyze the specimens. The obtained results indicate that the build direction has to be considered a key geometrical parameter affecting the overall quality of the obtained products.
Optimization of geometric parameters of soil nailing using response surface methodology
Authors: Benayoun Fadila , Boumezerane Djamalddine , Bekkouche Souhila Rehab , Ismail Fadhel 
Published: September 2021

AbstractOptimization of parameters of soil nailing is an important task in reinforcement soil problems. This paper focuses on the effect of nail geometric parameters on soil nailed wall analysis and identifies which factors that most affect their stability and cost using response surface methodology (RSM). RSM has been chosen to achieve an optimum combination of the soil nailing wall design. The influence of three factors has been considered; it included nail length, its inclination, and vertical spacing between nails. After a finite element analysis to model and perform the soil nailing simulations, a Box–Behnken design was applied, based on a set of experiments using various combinations. For this purpose, 15 runs were conducted to analyze tested parameters and to determine their interactions. The analysis of variance (ANOVA) and contour lines plots were investigated, and therefore, the most important parameters affecting the safety factor and the cost were identified. From the goodness-of-fit analyses of the model and the illustrative example, the proposed regression model provides a reasonably good estimate of the overall safety factor for soil nail walls and their cost. The results obtained from this study showed that RSM is an efficient and effective tool to identify the optimal combination, and it emerges that the safety factor and cost are most influenced by nail length and vertical spacing.
Ten Instructional Design Efforts to Help Behavior Analysts Take Up the Torch of Direct Instruction
Authors: Spencer Trina D. 
Published: September 2021

AbstractAlthough behavior analysts are trained in discrete trial instruction, other instructional approaches like Direct Instruction are underutilized in behavior analytic practice. Direct Instruction is a specialized technology that capitalizes on sophisticated instructional design and highly effective delivery strategies. What makes Direct Instruction so powerful is that it emphasizes the development of generative repertoires and establishes them efficiently. The purpose of this article is to introduce 10 critical instructional design efforts that behavior analysts can use in their practice, regardless of the population they serve and repertoires they build. The 10 instructional design efforts are summarized in a Direct Instruction Planning Guide. Behavior analysts can follow this sequence of design efforts and refer to the guiding questions as they develop efficient instruction for their learners. In doing so, behavior analysts can take up the torch of Direct Instruction, extend this remarkable instructional approach into their research and practice, and strengthen the behavioral technology available to behavior analytic practitioners.
I disordini endocrini nella pratica clinica: epidemiologia e domanda di salute nella vita reale
Authors: Crafa Andrea , Calogero Aldo E. , Condorelli Rosita A. , Cannarella Rossella , La Vignera Sandro 
Published: September 2021

SommarioLe patologie del sistema endocrino hanno un notevole impatto dal punto di vista epidemiologico sulla salute delle popolazioni. Esse sono in grado di alterare la qualità della vita dei pazienti affetti e sono responsabili di disabilità a lungo termine; si collocano al quinto posto tra le cause di morte. In questa revisione della letteratura abbiamo valutato la prevalenza e l’incidenza delle principali malattie endocrine nel mondo e in Italia per evidenziarne il reale impatto nella pratica clinica dell’endocrinologo.
Cost Dynamics of Clean Energy Technologies
Authors: Glenk Gunther , Meier Rebecca , Reichelstein Stefan 
Published: September 2021

AbstractThe pace of the global decarbonization process is widely believed to hinge on the rate of cost improvements for clean energy technologies, in particular renewable power and energy storage. This paper adopts the classical learning-by-doing framework of Wright (1936), which predicts that cost will fall as a function of the cumulative volume of past deployments. We first examine the learning curves for solar photovoltaic modules, wind turbines and electrolyzers. These estimates then become the basis for estimating the dynamics of the life-cycle cost of generating the corresponding clean energy, i.e., electricity from solar and wind power as well as hydrogen. Our calculations point to significant and sustained learning curves, which, in some contexts, predict a much more rapid cost decline than suggested by the traditional 80% learning curve. Finally, we argue that the observed learning curves for individual clean energy technologies reinforce each other in advancing the transition to a decarbonized energy economy.
Fast and exact audit scheduling optimization
Authors: Motl Jan , Kordík Pavel 
Published: September 2021

AbstractThis article is concerned with the cost and time-effective scheduling of financial auditors with integer linear programming. The schedule optimization considers 13 different constraints, staff scarcity, frequent alterations of the input data with the need to minimize the changes in the generated schedule, and scaling issues. The delivered implementation reduced the time to the first schedule from 3 man-days to 1 h and the schedule update time from 1 man-day to 4 min.
Estimation of the Ephemerides and Gravity Fields of the Galilean Moons Through Orbit Determination of the JUICE Mission
Authors: Magnanini Andrea 
Published: September 2021

AbstractJupiter and its moons are a complex dynamical system that include several phenomena like tides interactions, moon’s librations and resonances. One of the most interesting characteristics of the Jovian system is the presence of the Laplace resonance, where the orbital periods of Ganymede, Europa and Io maintain a 4:2:1 ratio, respectively. It is interesting to study the role of the Laplace resonance in the dynamic of the system, especially regarding the dissipative nature of the tidal interaction between Jupiter and its closest moon, Io. The secular orbital evolution of the Galilean satellites, and so the Laplace resonance, is strongly influenced by the tidal interaction between Jupiter and its moons, especially with Io. Numerous theories have been proposed regarding this topic, but they disagree about the amount of dissipation of the system, therefore about the magnitude and the direction of the evolution of the system, mainly because of the lack of experimental data. The future ESA JUICE space mission is a great opportunity to solve this dispute. The data that will be collect during the mission will have an exceptional accuracy, allowing to investigate several aspects of the dynamics the system and possibly the evolution of Laplace Resonance of the Galilean moons. This work will focus on the gravity estimation and orbit reconstruction of the Galilean satellites by precise orbit determination of the JUICE mission during the Jovian orbital phase using radiometric data.
Roles of Claspin in regulation of DNA replication, replication stress responses and oncogenesis in human cells
Authors: Hsiao Hao-Wen , Yang Chi-Chun , Masai Hisao 
Published: September 2021

AbstractHuman cells need to cope with the stalling of DNA replication to complete replication of the entire genome to minimize genome instability. They respond to “replication stress” by activating the conserved ATR-Claspin-Chk1 replication checkpoint pathway. The stalled replication fork is detected and stabilized by the checkpoint proteins to prevent disintegration of the replication fork, to remove the lesion or problems that are causing fork block, and to facilitate the continuation of fork progression. Claspin, a factor conserved from yeasts to human, plays a crucial role as a mediator that transmits the replication fork arrest signal from the sensor kinase, ataxia telangiectasia and Rad3-related (ATR), to the effector kinase, Checkpoint kinase 1 (Chk1). Claspin interacts with multiple kinases and replication factors and facilitates efficient replication fork progression and initiation during the normal course of DNA replication as well. It interacts with Cdc7 kinase through the acidic patch segment near the C-terminus and this interaction is critical for efficient phosphorylation of Mcm in non-cancer cells and also for checkpoint activation. Phosphorylation of Claspin by Cdc7, recruited to the acidic patch, regulates the conformation of Claspin through affecting the intramolecular interaction between the N- and C-terminal segments of Claspin. Abundance of Claspin is regulated at both mRNA and protein levels (post-transcriptional regulation and protein stability) and affects the extent of replication checkpoint. In this article, we will discuss how the ATR-Claspin-Chk1 regulates normal and stressed DNA replication and provide insight into the therapeutic potential of targeting replication checkpoint for efficient cancer cell death.