bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Function of Organic Additives in Enhancing the Q-values for Peat Pellet Biofuel
Authors: Nor Hashim Nor Zakiah , Embong Zaidi 
Published: November 2021

In Malaysia, peat make up for around 7.5 % of the entire land area. The positive effect of the vast wet organic compounds accumulates over a long time has stored high content of soil’s carbon which are highly useful as fuel and biomass energy generation. Thus, this study gives an outline of peat pellet as potential biofuel energy. The peat pellets were soaked into several kinds of flammable additives such as petrol, kerosene and diesel. The percentages of 69.41 % of carbon, 28.73% of oxygen and 0.97% of silicon were obtained using Energy Dispersive X-ray (EDX). The Fourier-Transformed Infrared (FTIR)- Attenuated Total Reflectance (ATR) Spectroscopy was used to identify the sample. From the spectra, it reveals that most of the additives contribute mainly functional groups with hydroxyl, alcohol and phenol groups were found leading to higher boiling and melting points. The heat combustion properties of peat pellets were evaluated using a calorimeter technique by boiling off 50 ml and 100 ml of water. The pellet with diesel has the highest Q-values and combustion rate due to larger number of carbons in rigid molecular structure. The high amount of unique chemical compound found naturally in diesel known as cetane, ignites effortlessly when heated gives diesel additional advantages in shorter ignition delays as well as longer duration of combustion.
ANALISIS KINERJA KEUANGAN MENGGUNAKAN METODE Z SCORE PADA PT. UNILEVER INDONESIA INDONESIA TBK
Authors: Wibowo Agung , Supramono Supramono , Kuraesin Ecin 
Published: November 2021

<p>Penelitian ini bertujuan untuk menganalisis kinerja keuangan perusahaan dengan metode Altman Z-Score menggunakan data sekunder yang diambil dari Bursa Efek Indonesia berupa laporan keuangan, dari perusahaan PT. Unilever Indonesia Tbk. Penelitian juga bertujuan untuk mengetahui ada tidaknya kesulitan keuangan atau pun tingkat kenerja keuangan berpotensi bankrupt atau tidak serta tingkat diantaranya yaitu wilayah abu-abu. Hasil dari perhitungan analisis Altman Z-Score pada PT Unilever Indonesia Tbk selama lima tahun tidak mengalami kesulitan keuangan meskipun mengalami penurunan terlihat pada tahun pertama tahun 2016 nilai Z Score sebesar 18,94, tahun 2017 mengalami penurunan menjadi 18,39 , tahun 2018 mengalami peningkatan menjadi 22,00 kemudian tahun 2018 turun menjadi 15,43 serta pada tahun 2020 turun lagi menjadi 13,90 Penurunan Z score dapat disebabkan beberapa factor seperti menurunnya penjualan yang terkait dengan pandemic Covid 19 khususnya penuruan pada tahun 2019 dan tahun 2020</p>
PENILAIAN PENGGUNAAN DOMPET DIGITAL SAAT PANDEMI Covid-19.
Authors: Bimo Widhi Ariyo 
Published: November 2021

<p>Salah satu kegiatan masyarakat yang meningkat saat pandemi Covid-19 adalah banyaknya transaksi digital dengan menggunakan DOMPET DIGITAL. Dompet Digital adalah, aplikasi elektronik yang dapat digunakan untuk melakukan transaksi keuangan secara online, tanpa uang fisik tunai (kertas atau logam) dan tanpa kartu, pengguna tinggal menggunakan smartphone dalam melakukan transaksi keuangannya. Tujuan dari penelitian ini adalah Untuk mengetahui penilaian penilaian penggunaan dompet digital saat pandemi covid-19.metode yang digunakan adalah deskriptif kualitatif menggunakan data primer yang dikumpulkan melalui kuisioner dengan responden. Kesimpulan dari penelitian ini menunjukan bahwa penilaian penggunaan dompet digital saat pandemi Covid-19 dari sisi Kinerja Penampilan (Tangible), Keandalan (Realibility) dan Perhatian (Empathy) adalah baik dan dapat diandalkan sedangkan yang perlu dilakukan peningkatan adalah dalam Kinerja Daya Tanggap (Responsivness) dan Jaminan (Assurance).</p>
DESAIN PADA KONTEKS KEBUDAYAAN
Authors: Wiyono Erina 
Published: November 2021

Di jaman modern, walaupun segala sesuatu didasari oleh logika, ilmu pasti dan teknologi, masyarakat tidak dapat melepaskan diri dari latar belakang kebudayaannya. Betapa pentingnya desainer dapat bertoleransi dalam mendesain, dan mengetahui sedikit banyak tentang budayanya ataupun budaya orang lain sehingga kenyaman client dalam menempati ruang yang didesain tercapai.
Epigenetics of skin intrinsic florescence
Authors: Guo Jiamin , Paterson Andrew , Roshandel Delnaz 
Published: November 2021

Introduction & Objective: Cumulated advanced glycation end products (AGEs) in the bloodstream and tissues contribute to the pathogenesis of diabetes complications. The skin intrinsic fluorescence (SIF) is a non-invasive measurement of dermal AGEs level using spectrometer, and it can be used as a biomarker in AGEs-related diseases. Previously, specific epigenomic factor has been found to be associated with haemoglobin A1c (HbA1c). HbA1c is a type of glycated haemoglobin – the HbA1c test measures the average glycemic control over the period of 3 months. However, the effect of epigenetic factors on the level of AGEs in the skin remains unknown. We hypothesize that some cytosine-guanine dinucleotides (CpGs) are associated with SIF. An epigenome-wide associations study (EWAS) was performed to identify CpG sites associated with SIF in people with type 1 diabetes.
Methods: 499 people with type 1 diabetes that have both methylation and SIF from the Diabetes Control Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were included. We fit linear regression models for SIF with each CpG site one at a time. The epigenome-wide significance level (p=5e-8) was applied. Then the result is compared with the null hypothesis where CpGs are not associated with SIF to check the inflation. In order to check the assumptions of the multiple linear models at a single CpG, we use diagnostic plots.
Results: We did not identify a specific CpG that is significantly associated with neither skin intrinsic fluorescence 1 (SIF1) nor skin intrinsic fluorescence 12 (SIF 12).The CpG site with strongest effect is cg06538183 ([SE] -2.73 [0.61], p = 8.72e-6) on SIF1 and cg12871967 ([SE] 2.52, 0.53, p = 2.71e-6) on SIF12.
Conclusion: We did not find any specific CpG that was significantly associated with either SIF 1 or SIF12. In general, the result suggests that DNA methylation does not impact the accumulation of AGEs in skin cells. DNA methylation data has a unique pattern of distribution that drives the non-uniform distribution of the p-values. The group of 275,301 CpGs that have means above the median and standard deviations below the median has the expected uniform p-value distribution.
Design of a Flexible Wasp-Inspired Tissue Transport Mechanism
Authors: de Kater Esther P. , Sakes Aimée , Bloemberg Jette , Jager David J. , Breedveld Paul 
Published: November 2021

Tissue transport is a challenge during Minimally Invasive Surgery (MIS) with the current suction-based instruments as the increasing length and miniaturisation of the outer diameter requires a higher pressure. Inspired by the wasp ovipositor, a slender and bendable organ through which eggs can be transported, a flexible transport mechanism for tissue was developed that does not require a pressure gradient. The flexible shaft of the mechanism consists of ring magnets and cables that can translate in a similar manner as the valves in the wasp ovipositor. The designed transport mechanism was able to transport 10wt% gelatine tissue phantoms with the shaft in straight and curved positions and in vertical orientation against gravity. The transport rate can be increased by increasing the rotational velocity of the cam. A rotational velocity of 25 RPM resulted in a transport rate of 0.8 mm/s and increasing the rotation velocity of the cam to 80 RPM increased the transport rate to 2.3 mm/s though the stroke efficiency decreased by increasing the rotational velocity of the cam. The transport performance of the flexible transport mechanism is promising. This means of transportation could in the future be an alternative for tissue transport during MIS.
Analysis of Intestinal Microflora and Metabolites From Mice With DSS-Induced IBD Treated With Schistosoma Soluble Egg Antigen
Authors: Zhu Tianyu , Xue Qingkai , Liu Yiyun , Xu Yongliang , Xiong Chunrong , Lu Jin , Yang Haitao , Zhang Quan , Huang Yuzheng 
Published: November 2021

Objective: This study aimed to analyze the changes in intestinal flora and metabolites in the intestinal contents of mice with inflammatory bowel disease (IBD) to preliminarily clarify the mechanism of action of Schistosoma soluble egg antigen (SEA) on IBD, thus, laying a research foundation for the subsequent treatment of IBD.Methods: A total of 40 Institute of Cancer Research (ICR) mice were divided into four groups: control, SEA 50 μg, dextran sulfate sodium salt (DSS), and SEA 50 μg + DSS. The overall state of the animals was observed continuously during modeling. The colonic length was measured after 10 days of modeling. The degree of colonic inflammation was observed by hematoxylin and eosin staining. 16srRNA and liquid chromatography–mass spectrometry sequencing techniques were used to determine the abundance of bacteria and metabolites in the intestinal contents of mice in the DSS and SEA 50 μg + DSS groups, and the differences were further analyzed.Results: After SEA intervention, the disease activity index score of mice with IBD decreased and the colon shortening was reduced. Microscopically, the lymphocyte aggregation, glandular atrophy, goblet cell disappearance, and colonic inflammation were less in the SEA 50 μg + DSS group than in the DSS group (p &lt; 0.0001). After SEA intervention, the abundance of beneficial bacteria prevotellaceae_UCG-001 was upregulated, while the abundance of the harmful bacteria Helicobacter, Lachnoclostridium, and Enterococcus was downregulated in the intestinal tract of mice with IBD. The intestinal metabolite analysis showed that SEA intervention decreased the intestinal contents of glycerophospholipids (lysophosphatidylcholine, lysophosphatidylethanolamine, phatidylcholine, and phatidylethanolamine) and carboxylic acids (L-alloisoleucine and L-glutamate), whereas increased bile acids and their derivatives (3B,7A,12a-trihydroxy-5A-cholanoic acid and 3A,4B, 12a-trihydroxy-5b-cholanoic acid). Combined microbiota–metabolite analysis revealed a correlation between these differential microbiota and differential metabolites. At the same time, the changes in the contents of metabolites and differential metabolites in the two groups also correlated with the abundance of the gut microbiome.Conclusions: The study showed that SEA reduced DSS-induced inflammation in IBD and improved the symptoms of IBD in mice through the combined regulation of intestinal flora and intestinal metabolism. It suggested a potential possibility for the use of SEA in treating and regulating intestinal flora and metabolism in patients with IBD.
Evaluation of Marine Gravity Anomaly Calculation Accuracy by Multi-Source Satellite Altimetry Data
Authors: Liu Shanwei , Li Yinlong , Sun Qinting , Wan Jianhua , Jiao Yue , Jiang Jinghui 
Published: November 2021

The purpose of this paper is to analyze the influence of satellite altimetry data accuracy on the marine gravity anomaly accuracy. The data of 12 altimetry satellites in the research area (5°N–23°N, 105°E–118°E) were selected. These data were classified into three groups: A, B, and C, according to the track density, the accuracy of the altimetry satellites, and the differences of self-crossover. Group A contains CryoSat-2, group B includes Geosat, ERS-1, ERS-2, and Envisat, and group C comprises T/P, Jason-1/2/3, HY-2A, SARAL, and Sentinel-3A. In Experiment I, the 5′×5′ marine gravity anomalies were obtained based on the data of groups A, B, and C, respectively. Compared with the shipborne gravity data, the root mean square error (RMSE) of groups A, B, and C was 4.59 mGal, 4.61 mGal, and 4.51 mGal, respectively. The results show that high-precision satellite altimetry data can improve the calculation accuracy of gravity anomaly, and the single satellite CryoSat-2 enables achieving the same effect of multi-satellite joint processing. In Experiment II, the 2′×2′ marine gravity anomalies were acquired based on the data of groups A, A + B, and A + C, respectively. The root mean square error of the above three groups was, respectively, 4.29 mGal, 4.30 mGal, and 4.21 mGal, and the outcomes show that when the spatial resolution is satisfied, adding redundant low-precision altimetry data will add pressure to the calculation of marine gravity anomalies and will not improve the accuracy. An effective combination of multi-satellite data can improve the accuracy and spatial resolution of the marine gravity anomaly inversion.
The Asymmetric Precipitation Evolution in Weak Landfalling Tropical Cyclone Rumbia (2018) Over East China
Authors: Tang Lichun , Wang Yuqing , Yu Zifeng , Wang Lan 
Published: November 2021

The rainfall in landfalling TC is not always correlated with the storm intensity. Some weak landfalling TCs could bring extremely heavy rainfall during and after landfall. Such extreme events are very challenging to operational forecasts and often lead to disasters in the affected regions. Tropical storm Rumbia (2018) made its landfall in Shanghai with weak intensity but led to long-lasting and increasing rainfall to East China. The asymmetric rainfall evolution of Rumbia during and after its landfall was diagnosed based on the fifth generation European Centre for Medium-Range Weather Forecasting (ECMWF) reanalysis (ERA5) data, the tropical cyclone (TC) best-track data, and rainfall observations from China Meteorological Administration (CMA). Results showed that Rumbia was embedded in an environment with a deep-layer (300–850 hPa) southwesterly vertical wind shear (VWS). The maximum rainfall mostly occurred downshear-left in its inner-core region and downshear-right in the outer-core region. The translation of Rumbia also contributed to the rainfall distribution to some extent, especially prior to and just after its landfall. The strong southwesterly-southeasterly summer monsoon flow transported water vapor from the tropical ocean and the East China Sea to the TC core region, providing moisture and convective instability conditions in the mid-lower troposphere for the sustained rainfall even after Rumbia moved well inland. The results also showed that the low-level convective instability and the deep-layer environmental VWS played an important role in deepening the inflow boundary layer and the redevelopment of the secondary circulation, thus contributing to the heavy rainfall in the northeast quadrant of Rumbia after its landfall. However, further in-depth studies are recommended in regard of the rainfall evolution in the weak TCs. This study further calls for a continuous understanding of the involved physical processes/mechanisms that are responsible for the extreme rainfall induced by landfalling TCs, which can help improve the rainfall forecast skills and support damage mitigation in the future.
Antioxidant Potential and Inhibition of Mitochondrial Permeability Transition Pore by Myricetin Reduces Aluminium Phosphide-Induced Cytotoxicity and Mitochondrial Impairments
Authors: Salimi Ahmad , Jamali Zhaleh , Shabani Mohammad 
Published: November 2021

Oxidative stress and mitochondrial dysfunction are involved in the mechanisms of cardiac toxicity induced by aluminum phosphide (AlP). AlP-induced cardiotoxicity leads to cardiomyocyte death, cardiomyopathy, cardiac dysfunction, and eventually severe heart failure and death. Importantly, protecting cardiomyocytes from death resulting from AlP is vital for improving survival. It has been reported that flavonoids such as myricetin (Myr) act as modifiers of mitochondrial function and prevent mitochondrial damage resulting from many insults and subsequent cell dysfunction. In this study, the ameliorative effect of Myr, as an important antioxidant and mitochondrial protective agent, was investigated in cardiomyocytes and mitochondria isolated from rat heart against AlP-induced toxicity, oxidative stress, and mitochondrial dysfunction. Treatment of AlP (20 μg/ml) significantly increased cytotoxicity; reduced glutathione (GSH) depletion, cellular reactive oxygen species (ROS) formation, malondialdehyde (MDA) level, ATP depletion, caspase-3 activation, mitochondrial membrane potential (ΔΨm) collapse, and lysosomal dysfunction; and decreased the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in intact cardiomyocytes. Also, treatment of AlP (20 μg/ml) significantly increased mitochondrial dysfunction and swelling in isolated mitochondria. Myr (80 µM) appeared to ameliorate AlP-induced cytotoxicity in isolated cardiomyocytes; significantly lessened the AlP-stimulated intracellular ROS and MDA production and depletion of GSH; and increased the activities of SOD, CAT, and GSH-Px. Furthermore, Myr (40 and 80 µM) lowered AlP-induced lysosomal/mitochondrial dysfunction, ATP depletion, and caspase-3 activation. In the light of these findings, we concluded that Myr through antioxidant potential and inhibition of mitochondrial permeability transition (MPT) pore exerted an ameliorative role in AlP-induced toxicity in isolated cardiomyocytes and mitochondria, and it would be valuable to examine its in vivo effects.
In silico Identification of Disrupted Myocardial Calcium Homeostasis as Proarrhythmic Trigger in Arrhythmogenic Cardiomyopathy
Authors: Lyon Aurore , van Opbergen Chantal J. M. , Delmar Mario , Heijman Jordi , van Veen Toon A. B. 
Published: November 2021

Background: Patients with arrhythmogenic cardiomyopathy may suffer from lethal ventricular arrhythmias. Arrhythmogenic cardiomyopathy is predominantly triggered by mutations in plakophilin-2, a key component of cell-to-cell adhesion and calcium cycling regulation in cardiomyocytes. Calcium dysregulation due to plakophilin-2 mutations may lead to arrhythmias but the underlying pro-arrhythmic mechanisms remain unclear.Aim: To unravel the mechanisms by which calcium-handling abnormalities in plakophilin-2 loss-of-function may contribute to proarrhythmic events in arrhythmogenic cardiomyopathy.Methods: We adapted a computer model of mouse ventricular electrophysiology using recent experimental calcium-handling data from plakophilin-2 conditional knock-out (PKP2-cKO) mice. We simulated individual effects of beta-adrenergic stimulation, modifications in connexin43-mediated calcium entry, sodium-calcium exchanger (NCX) activity and ryanodine-receptor 2 (RyR2) calcium affinity on cellular electrophysiology and occurrence of arrhythmogenic events (delayed-afterdepolarizations). A population-of-models approach was used to investigate the generalizability of our findings. Finally, we assessed the potential translation of proposed mechanisms to humans, using a human ventricular cardiomyocyte computational model.Results: The model robustly reproduced the experimental calcium-handling changes in PKP2-cKO cardiomyocytes: an increased calcium transient amplitude (562 vs. 383 nM), increased diastolic calcium (120 vs. 91 nM), reduced L-type calcium current (15.0 vs. 21.4 pA/pF) and an increased free SR calcium (0.69 vs. 0.50 mM). Under beta-adrenergic stimulation, PKP2-cKO models from the population of models (n = 61) showed a higher susceptibility to delayed-afterdepolarizations compared to control (41 vs. 3.3%). Increased connexin43-mediated calcium entry further elevated the number of delayed-afterdepolarizations (78.7%, 2.5-fold increase in background calcium influx). Elevated diastolic cleft calcium appeared responsible for the increased RyR2-mediated calcium leak, promoting delayed-afterdepolarizations occurrence. A reduction in RyR2 calcium affinity prevented delayed-afterdepolarizations in PKP2-cKO models (24.6 vs. 41%). An additional increase in INCX strongly reduced delayed-afterdepolarizations occurrence, by lowering diastolic cleft calcium levels. The human model showed similar outcomes, suggesting a potential translational value of these findings.Conclusion: Beta-adrenergic stimulation and connexin43-mediated calcium entry upon loss of plakophilin-2 function contribute to generation of delayed-afterdepolarizations. RyR2 and NCX dysregulation play a key role in modulating these proarrhythmic events. This work provides insights into potential future antiarrhythmic strategies in arrhythmogenic cardiomyopathy due to plakophilin-2 loss-of-function.
The Swedish Version of the Multidimensional Inventory for Religious/Spiritual Well-Being: First Results From Swedish Students
Authors: Wenzl Magdalena , Fuchshuber Jürgen , Podolin-Danner Nikita , Silani Giorgia , Unterrainer Human-Friedrich 
Published: November 2021

Background: Studies investigating the relationship between religiosity/spirituality and mental health have suggested both positive and negative associations, highlighting the importance of multifaceted assessment of these rather broad constructs. The present study aims at contributing to this field of research by providing a validated Swedish version of the Multidimensional Inventory for Religious/Spiritual Well-Being (MI-RSWB-S) and further examining how this instrument relates to Big Five personality factors, Sense of Coherence (SOC), and religiosity.Methods: Data were collected from a total of 1,011 Swedish students (747 females; age range 18–40) via completion of an online survey, including a new Swedish Version of the MI-RSWB-S, the Ten Item Personality Inventory (TIPI), the Sense of Coherence Scale (SOC-13), and the Centrality of Religiosity Scale (CRS-5).Results: Results revealed adequate estimates of internal consistency and substantial evidence for the postulated six-dimensional structure. However, confirmatory factor analysis yielded poor fit indices, resulting in the development and validation of a revised measure of Religious/Spiritual Well-Being (RSWB), comprising the subscales General Religiosity and Connectedness. Most of the MI-RSWB-S dimensions were positively correlated with the personality domains Extraversion, Openness to Experience, Conscientiousness, and Agreeableness and negatively related to Neuroticism. SOC was positively linked to Hope Immanent, Forgiveness, Hope Transcendent, and Experiences of Sense of Meaning, whereas CRS exhibited positive correlations with all MI-RSWB-S subscales except Hope Transcendent.Conclusion: The findings of the current study support the validity and reliability of the Swedish adoption of the MI-RSWB and confirm previously reported associations with the Big Five personality traits, SOC, and CRS. More in general, our results underline the putative substantial link between RSWB dimensions and mental health. Further research especially in clinical surroundings as well as by employing more representative samples is now warranted.