bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geschwindigkeit durch industrialisiertes Bauen
Authors: Schwab Delphine , Six Michael 
Published: September 2021

AbstractGOLDBECK zählt zu den führenden Bauunternehmen Europas und gilt als Innovationstreiber der Branche. Der Schwerpunkt des Unternehmens liegt auf der Planung und dem Bau von schlüsselfertigen Gewerbeimmobilien, darunter Produktions‐ und Logistikhallen, Bürogebäude, Parkhäuser sowie Schulen und Wohngebäude. Bauen im Bestand und gebäudenahe Serviceleistungen gehören ebenfalls zum Leistungsportfolio. Allein im Geschäftsjahr 2020/2021 wurden mehr als 500 Projekte bei einer Gesamtleistung von über 4 Mrd. Euro realisiert. Möglich wird dies durch die seit den 1980er Jahren angewandte Bauweise: Nach dem Vorbild der Automobilindustrie hat das Unternehmen die eigenen Prozesse entlang der gesamten Wertschöpfung systematisiert. Gebäude werden inhouse geplant und konstruiert, wesentliche Bauelemente werden in Form von Systemelementen in aktuell zehn eigenen Produktionswerken industriell vorgefertigt. Hinzu kommen optimierte Logistikprozesse, die eine Anlieferung und Montage „just in time” (zum richtigen Zeitpunkt) und sogar „just in sequence” (zum richtigen Zeitpunkt und in der richtigen Montagereihenfolge) ermöglichen. In Summe führt diese Bauweise zu schnellem, kostensicherem und hochwertigem Bauen. Der Bericht erläutert die GOLDBECK‐typische Planungs‐ und Bauweise und gibt anhand von aktuellen Projekten einen Einblick in die Umsetzung in der Praxis.
Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology
Authors: Wikramanayake Tongyu C. , Nicu Carina , Chéret Jérémy , Czyzyk Traci A. , Paus Ralf 
Published: September 2021

AbstractMPZL3 is a nuclear‐encoded, mitochondrially localized, immunoglobulin‐like V‐type protein that functions as a key regulator of epithelial cell differentiation, lipid metabolism, ROS production, glycemic control, and energy expenditure. Recently, MPZL3 has surfaced as an important modulator of sebaceous gland function and of hair follicle cycling, an organ transformation process that is also governed by peripheral clock gene activity and PPARγ. Given the phenotype similarities and differences between Mpzl3 and Pparγ knockout mice, we propose that MPZL3 serves as a signaling hub that is regulated by core clock gene products and/or PPARγ to translate signals from these nuclear transcription factors to the mitochondria to modulate circadian and metabolic regulation. Conservation between murine and human MPZL3 suggests that human MPZL3 may have similarly complex functions in health and disease. We summarize current knowledge and discuss future directions to elucidate the full spectrum of MPZL3 functions in mammalian physiology.
Stability‐indicating reversed‐phase‐HPLC method development and validation for sacubitril/valsartan complex in the presence of impurities and degradation products: Robustness by quality‐by‐design approach
Authors: Subramanian Velusamy B. , Katari Naresh Kumar , Ponnam Vijetha , Konduru Naresh , Dongala Thirupathi , Marisetti Vishnu M. , Vyas Govind 
Published: September 2021

AbstractAccording to current regulatory guidelines, a stability‐indicating method has been developed to determine the impurities in sacubitril (SCB) and valsartan (VLS) tablet dosage forms and perform robustness studies using the design of experiments approach. The present study was initiated to understand quality target product profile, analytical target profile, and risk assessment for method variables that affect the method response. A reversed‐phase‐HPLC system was equipped with a Phenomenex Gemini‐NX C18 column (150 × 4.6 mm, 3 μm) and a photo diode array detector. A gradient mobile phase was used in this research work. The detection was performed at 254 nm; the flow rate was 1.5 mL/min, and the column temperature was maintained at 30°C. The proposed method was validated per the International Council for Harmonisation Q2 (R1) guidelines. The coefficient of correlation was >0.999 for all impurities. The limits of detection and quantification were evaluated for SCB, VLS, and all impurities. The precision and accuracy were obtained for SCB, VLS, and their related impurities. Intra‐ and inter‐day relative standard deviation values were less than 10.0%, and the recoveries of impurities varied between 90.0 and 115.0%. Based on the validation results, the proposed DoE method can estimate SCB and VLS impurities in the finished dosage form.
When Supramolecular Chemistry Meets Chemical Biology: New Strategies to Target Proteins through Host‐Guest Interactions
Authors: Cao Wenbing , Qin Xuewen , Liu Tao 
Published: September 2021

AbstractSupramolecular chemistry for targeting proteins is of great interest for the development of novel approaches to recognize, isolate and control proteins. Taking advantage of chemical biology approaches, such as genetic‐code expansion and enzyme‐mediated ligation, guest recognition elements can be built into proteins of interest, allowing supramolecular control of protein function and regulation. In this viewpoint article, we will discuss the methods, applications, limitations, and future perspectives of supramolecular chemistry for targeting proteins in a site‐specific manner.
Mathematical Modeling of Air Impingement Drying of the Brown Algae Sargassum muticum (Fucales)
Authors: Le Loeuff Jeanne , Boy Virginie , Morançais Pascal , Colinart Thibaut , Bourgougnon Nathalie , Lanoisellé Jean-Louis 
Published: September 2021

AbstractThe impact of air velocity and temperature on the drying curves of the invasive brown alga Sargassum muticum was evaluated. An air impingement dryer was applied at five air velocities and four air temperatures. The equilibrium moisture content was properly modeled by Oswin, Halsey, and GAB models. Fick's diffusional model was employed to identify the apparent moisture diffusivity. The variations of the diffusivity versus temperature and velocity were determined. Three semi‐empirical expressions, namely, Page, two‐term, and Henderson‐Pabis modified equations were selected to fit the drying kinetics. The two‐term equation was the most appropriate to model the experimental data.
Creation of Liquid‐Air Dispersions in Oil and Water: Comparison of Calculations and Measurements
Authors: Hafner Lukas , Schwarzer Steffen , Dohnal Fadi 
Published: September 2021

AbstractThe creation of liquid‐gas dispersions places very high demands on the process technology, which requires knowledge of bubble formation mechanisms. To extend the range of validity of the current calculation models to larger viscosity differences, the bubble formation mechanisms for the media combination oil/air are investigated. Compared to the media combination water/air, significant differences occur. The results obtained here will make it possible to design bubble columns in a more targeted manner in the future, which will lead to savings in resources and energy of industrial test stands.
Design and Synthesis of Highly Potent and Specific ABHD6 Inhibitors
Authors: Malamas Michael S. , Lamani Manjunath , Farah Shrouq I. , Mohammad Khadijah A. , Miyabe Christina Yume , Rajarshi Girija , Wu Simiao , Zvonok Nikolai , Chandrashekhar Honrao , Wood JodiAnne , Makriyannis Alexandros 
Published: September 2021

AbstractFine‐tuning than complete disruption of 2‐arachidonoylglycerol (2‐AG) metabolism in the brain represents a promising pharmacological approach to limit potential untoward effects associated with complete blockade of monoacylglycerol lipase (MGL), the primary hydrolase of 2‐AG. This could be achieved through a/b‐hydrolase domain containing 6 (ABHD6) inhibition, which will provide a smaller and safer contribution to 2‐AG regulation in the brain. Pharmacological studies with ABHD6 inhibitors have recently been reported, where modulation of ABHD6 activity either through CB1R‐dependent or CB1R‐independent processes showed promise in preclinical models of epilepsy, neuropathic pain and inflammation. Furthermore in the periphery, ABHD6 modulates 2‐AG and other fatty acid monoacylglycerols (MAGs) and is implicated in Type‐2 diabetes, metabolic syndrome and potentially other diseases. Herein, we report the discovery of single‐digit nanomolar potent and highly specific ABHD6 inhibitors with >1000‐fold selectivity against MGL and FAAH. The new ABHD6 inhibitors provide early leads to develop therapeutics for neuroprotection and the treatment of inflammation and diabetes.
‘I think it does just opens it up and … you're not hiding it anymore’: Trainee clinical psychologists' experiences of self‐disclosing mental health difficulties
Authors: Turner Kellie , Moses Jenny , Neal Adrian 
Published: September 2021

AbstractSelf‐disclosure of experiences of mental health difficulties is a complex process, particularly within the workplace. Research shows that a significant number of trainee clinical psychologists have lived experience of mental health difficulties and thus face the dilemma of whether to disclose and how to manage self‐disclosure during doctoral training. Grounded theory methodology was used to explore trainee experiences of self‐disclosure of mental health difficulties during training. Twelve trainee clinical psychologists from accredited doctoral programmes in the United Kingdom participated in semi‐structured interviews about their experiences of disclosure. Six core categories emerged relating to ‘motivations’, ‘enablers’, ‘barriers’, ‘features of disclosure’, ‘responses’ and ‘impact’, each of which were comprised of several further sub‐categories. The model that emerged is largely consistent with research on disclosure in healthcare professions and has implications for training programmes, supervisors and trainees when engaging in conversations about lived experience.
Soil moisture, N, P, and forest cover effects on N fixation in alders in the southern boreal forest
Authors: Markham John , Anderson Paige 
Published: September 2021

AbstractOutside of tropical and arid regions, plant productivity is limited by the availability of soil N. Ironically, these are the regions where N‐fixing plants are restricted to early successional habitats. The energy cost of N fixation has been used to explain the paucity of N‐fixing plants in late‐successional ecosystems, and models predict reduced light and increased soil N availability will reduce N‐fixing plant success. The lack of success of N‐fixing plants has also been explained by their greater need for some elements, especially phosphorus. We examined the effect of N and P fertilizer over four years on N fixation in Alnus alnobetula spp. crispa in a mature Pinus banksiana forest in the southern boreal forest, and an adjacent site where wildfire had removed the tree canopy. We also monitored N fixation throughout two growing seasons examined the effect of artificial shading on photosynthesis. The addition of N or P fertilizer resulted in a 60% decrease in plant nodule nitrogenase activity. N fertilizer also reduced the proportion of cells in the root nodules containing N‐fixing vesicles in the forest site. Shrubs in the forest had the highest photosynthetic rate when measured on a leaf mass basis, indicating an increased carbon capture efficiency compared with shrubs in the open. Over the course of two growing seasons, soil temperature had a positive effect on specific nitrogenase activity, and soil in the open site was warmer than soil in the forest in the spring. However, as soil moisture decreased, temperature was a weaker predictor of nitrogenase activity. Although all shrubs consistently acquired most of their N from fixation, shrubs in the forest derived more than shrubs in the open, which were more water limited. Overall, these results show that N‐fixing plants may benefit from being in the understory for improved water balance in this region of the boreal forest. As such, light availability may not be the primary factor limiting the abundance of N‐fixing shrubs.
Egg Yolk Phospholipids Modulate Microbial Imbalance in the Intestinal Tract of Rats on a High‐Fructose Diet
Authors: Yin Mingyu , Zhang Long , Tang Shijie , Matsuoka Ryosuke , Xi Yinci , Tao Ningping , Wang Xichang 
Published: September 2021

AbstractHigh‐fructose diet (HFD), a cause of excessive obesity and destruction of the structure of the intestinal ecosystem, has become a common eating habit. This study aims to explore the effect and mechanism of egg yolk phospholipids (EPLs) on improving obesity, intestinal short‐chain fatty acids (SCFAs), and intestinal bacterial structure in rats induced by HFD. Results indicate that EPLs exhibit better effects on anti‐obesity than those of soy phospholipids (SPLs). EPLs increase the reduction of SCFAs caused by HFD, increased acetic acid, propionic acid, isobutyric acid, and total SCFAs, which effectively regulate the environment of intestinal microbial metabolism. Moreover, EPLs decrease Firmicutes/Bacteroides ratio (F/B) and the relative abundance of Streptomyces, Arthrobacter, and Desulfovibrio, and increase the relative abundance of Mucilaginibacter and Cellulomonas. These results suggest that EPLs have a potential modulating effect on intestinal disorders caused by HFD.Practical Applications: The results of this study illustrate that phospholipids are a promising supplement to alleviate the intestinal flora disorder caused by a high‐fructose diet, and its protective effect is mainly to regulate the composition of intestinal short‐chain fatty acids.
Low‐carbon economic operation for integrated energy system considering carbon trading mechanism
Authors: Sun Peiran , Hao Xuejun , Wang Jun , Shen Di , Tian Lu 
Published: September 2021

AbstractCarbon trading mechanism is an effective means to control greenhouse gas emissions. This paper focuses on the low‐carbon economic operation of the integrated energy system under carbon trading mechanism in China. The integrated energy system includes the energy storage, ground source heat pump, and other equipment. The objective of this paper was to minimize the annual total cost of the system considering the carbon trading cost and study the operation modes under different carbon trading prices by commercial optimization software. The simulation results show the operation modes in summer are changed obviously with the increase of the carbon trading prices, while the operation modes in winter basically are not changed with the fluctuation of the carbon trading prices; under the carbon trading mechanism, the integrated energy system can not only reduce the carbon emissions, but also reduce the annual total cost through carbon trading, which shows its advantages and good development prospect. In addition, the setting of the carbon emission quota has a direct impact on the economy of the enterprises. Furthermore, the ground source heat pump and the electric refrigeration units can stabilize the fluctuation of the equipment output caused by the change of natural gas prices in this integrated energy system.
Yogurt fortified with omega‐3 using nanoemulsion containing flaxseed oil: Investigation of physicochemical properties
Authors: Almasi Khadijeh , Esnaashari Seyedeh Sara , Khosravani Masood , Adabi Mahdi 
Published: September 2021

AbstractFlaxseed oil as a natural ingredient has many health benefits due to the rich contents of omega‐3 fatty acids. However, its use in food formulations is limited because of low aqueous solubility, easy oxidation owing to the unsaturated nature of the fatty acids such as omega‐3. The aim of this study was to prepare a stable nanoemulsion containing flaxseed oil and investigate the fortification of yogurt with this nanoemulsion compared with fortification with bulk flaxseed oil. The nanoemulsion of flaxseed oil‐in‐water was obtained by low‐energy emulsification method. Optimized nanoemulsion contains 3% (w/w) flaxseed vegetable oil, 36% (w/w) surfactant, 10% (w/w) co‐surfactant, and 51% (w/w) deionized water as a continuous phase. The result of transmission electron microscopy (TEM) showed that the optimal size was about 60 nm, which was stayed stable for 11 months. The results of gas chromatography (GC) indicated that the amount of omega‐3 in nanoemulsion containing flaxseed oil was 27.3% and 19.8% after 7 days and 11 months, respectively. The turbidity results indicated the transparency of nanoemulsion after 11 months as well. The results of centrifuge experiments and thermal stress cycles exhibited that the optimized nanoemulsion was physically stable without any sign of creaming, phase separation, and cracking. In addition, pH and acidity of the yogurt fortified with nanoemulsion containing flaxseed oil were 4.22 and 1.41 wt%, respectively. In conclusion, fortifying yogurt with the nanoemulsion containing flaxseed oil can be considered as a solution to increase solubility, bioavailability, and protection of omega‐3.
Geoarchaeological studies in the early medieval Santok stronghold (north‐western Poland)
Authors: Zamelska‐Monczak Kinga , Piotrowski Andrzej , Sydor Paweł , Żuk Tomasz , Rzodkiewicz Monika , Noryśkiewicz Agnieszka , Krzymińska Jarmila 
Published: September 2021

AbstractSantok played a strategic socio‐political role in the Early Middle Ages. It is situated at the confluence of two large rivers (Warta and Noteć) on the boundary of historical regions in north‐western Poland. The stronghold in Santok is located on a sandy elevated floodplain with frequent floods in the immediate vicinity of the morainic plateau. The geological and engineering conditions within the stronghold were complex, making it a very difficult area for construction. The oldest settlement in Santok was established in the 8th century AD as a seasonal exchange point. By the 10th century, a well‐fortified fortress was built as a strategic centre at the border of the first Polish state. Santok's stronghold was maintained for over 600 years, during which the community benefited from its wetland location and useful waterways connecting local and distant territories. The extended use of one location in Santok allowed for investigation of the anthropogenic and natural environmental changes throughout a long time period. Given its past significance, this area has become a key geoarchaeological site to understand human–environment interactions of the western Slavs in the Early Middle Ages.
Heat and mass transfer of triple diffusive convection in viscoelastic liquids under internal heat source modulations
Authors: Noor Arshika S. , Tarannum Sameena , Pranesh Subbarama 
Published: September 2021

AbstractThe influence of sinusoidal (trigonometric cosine [TC]) and nonsinusoidal waveforms (square, sawtooth, and triangular) of internal heat source modulation on triple diffusive convection in viscoelastic liquids is investigated. An Oldroyd‐B type model is taken into account for viscoelastic liquids. Nonlinear analysis is carried out using a truncated representation of the Fourier series. To analyze the heat and mass transfer over a triply diffusive liquid layer, expressions for average Nusselt and average Sherwood numbers are derived using 8‐mode generalized Lorenz equations. The transient behavior of Nusselt and Sherwood numbers is analyzed on different parameters of the problem. From the results, it is found that the internal heat source enhances the heat transfer and diminishes the mass transfer while the heat sink diminishes the heat transfer and enhances the mass transfer. The results for respective waveforms are obtained for each parameter and it is found that the maximum heat and mass transfer occurs due to TC waveform. The limiting cases of viscoelastic liquids (Newtonian, Oldroyd‐B, Maxwell, and Rivlin–Ericksen) have been tabulated and corresponding results for each of the waveforms on heat and mass transfer have been shown.
Marangoni convection flow of γ–Al2O3 nanofluids past a porous stretching surface with thermal radiation effect in the presence of an inclined magnetic field
Authors: Dadheech Praveen Kumar , Agrawal Priyanka , Sharma Anil , Nisar Kottakkaran Sooppy , Purohit Sunil Dutt 
Published: September 2021

AbstractThe aim of this study is to investigate the heat transfer effect of γ–Al2O3 nanofluid flow with Marangoni convection over a porous stretching surface. Here, the aligned magnetic field is also considered. Ethylene glycol and water are taken as base fluids. Thermal radiation is incorporated nonlinearly for the temperature field. Comparisons between two Ethylene glycol and water‐based γ–Al2O3 nanofluids have been discussed graphically. The governing model of the flow is solved by the Runge–Kutta fourth‐order method using the appropriate similarity transformations. Temperature and velocity field are presented for various flow pertinent parameters. It is observed that the Ethylene glycol‐based γ–Al2O3 nanofluid is more significant in the cooling process than the water‐based. nanofluid. An increment in the temperature field has been noticed for increased values of with , and for both the γ–Al2O3–H2O nanofluid and γ–Al2O3–C2H6O2 nanofluid.
Mechanisms and biological impacts of graphene and multi‐walled carbon nanotubes on Drosophila melanogaster: Oxidative stress, genotoxic damage, phenotypic variations, locomotor behavior, parasitoid resistance, and cellular immune response
Authors: Demir Eşref 
Published: September 2021

AbstractThe use of graphene and multi‐walled carbon nanotubes (MWCNTs) has now become rather common in medical applications as well as several other areas thanks to their useful physicochemical properties. While in vitro testing offers some potential, in vivo research into toxic effects of graphene and MWCNTs could yield much more reliable data. Drosophila melanogaster has recently gained significant popularity as a dynamic eukaryotic model in examining toxicity, genotoxicity, and biological effects of exposure to nanomaterials, including oxidative stress, cellular immune response against two strains (NSRef and G486) of parasitoid wasp (Leptopilina boulardi), phenotypic variations, and locomotor behavior risks. D. melanogaster was used as a model organism in our study to identify the potential risks of exposure to graphene (thickness: 2–18 nm) and MWCNTs in different properties (as pure [OD: 10–20 nm short], modified by amide [NH2] [OD: 7–13 nm length: 55 μm], and modified by carboxyl [COOH] [OD: 30–50 nm and length: 0.5–2 μm]) at concentrations ranging from 0.1 to 250 μg/ml. Significant effects were observed at two high doses (100 and 250 μg/ml) of graphene or MWCNTs. This is the first study to report findings of cellular immune response against hematopoiesis and parasitoids, nanogenotoxicity, phenotypic variations, and locomotor behavior in D. melanogaster.