bluuebunny/crossref_metadata_2025_split huggingface dataset:
An obstacle to sub-AdS holography for SYK-like models
Authors: Zhang Pengfei , Gu Yingfei , Kitaev Alexei 
Published: March 2021

Abstract
We argue that “stringy” effects in a putative gravity-dual picture for SYK-like models are related to the branching time, a kinetic coefficient defined in terms of the retarded kernel. A bound on the branching time is established assuming that the leading diagrams are ladders with thin rungs. Thus, such models are unlikely candidates for sub-AdS holography. In the weak coupling limit, we derive a relation between the branching time, the Lyapunov exponent, and the quasiparticle lifetime using two different approximations.
The minimally displaced set of an irreducible automorphism of $$F_N$$ is co-compact
Authors: Francaviglia Stefano , Martino Armando , Syrigos Dionysios 
Published: March 2021

AbstractWe study the minimally displaced set of irreducible automorphisms of a free group. Our main result is the co-compactness of the minimally displaced set of an irreducible automorphism with exponential growth $$\phi $$
ϕ
, under the action of the centraliser $$C(\phi )$$

C
(
ϕ
)

. As a corollary, we get that the same holds for the action of $$ <\phi>$$

<
ϕ
>

on $$Min(\phi )$$

M
i
n
(
ϕ
)

. Finally, we prove that the minimally displaced set of an irreducible automorphism of growth rate one consists of a single point.
Design of an improved universal signal peptide based on the α-factor mating secretion signal for enzyme production in yeast
Authors: Aza Pablo , Molpeceres Gonzalo , de Salas Felipe , Camarero Susana 
Published: March 2021

AbstractSaccharomyces cerevisiae plays an important role in the heterologous expression of an array of proteins due to its easy manipulation, low requirements and ability for protein post-translational modifications. The implementation of the preproleader secretion signal of the α-factor mating pheromone from this yeast contributes to increase the production yields by targeting the foreign protein to the extracellular environment. The use of this signal peptide combined with enzyme-directed evolution allowed us to achieve the otherwise difficult functional expression of fungal laccases in S. cerevisiae, obtaining different evolved α-factor preproleader sequences that enhance laccase secretion. However, the design of a universal signal peptide to enhance the production of heterologous proteins in S. cerevisiae is a pending challenge. We describe here the optimisation of the α-factor preproleader to improve recombinant enzyme production in S. cerevisiae through two parallel engineering strategies: a bottom-up design over the native α-factor preproleader (αnat) and a top-down design over the fittest evolved signal peptide obtained in our lab (α9H2 leader). The goal was to analyse the effect of mutations accumulated in the signal sequence throughout iterations of directed evolution, or of other reported mutations, and their possible epistatic interactions. Both approaches agreed in the positive synergism of four mutations (Aα9D, Aα20T, Lα42S, Dα83E) contained in the final optimised leader (αOPT), which notably enhanced the secretion of several fungal oxidoreductases and hydrolases. Additionally, we suggest a guideline to further drive the heterologous production of a particular enzyme based on combinatorial saturation mutagenesis of positions 86th and 87th of the αOPT leader fused to the target protein.
Prognostic Significance of Myocardial Ischemia Detected by Single-Photon Emission Computed Tomography in Children with Hypertrophic Cardiomyopathy
Authors: Ziolkowska Lidia , Boruc Agnieszka , Sobielarska-Lysiak Dorota , Grzyb Agnieszka , Petryka-Mazurkiewicz Joanna , Mazurkiewicz Łukasz , Brzezinska-Rajszys Grazyna 
Published: March 2021

AbstractMyocardial ischemia caused by microvascular dysfunction is an important pathophysiologic component of hypertrophic cardiomyopathy (HCM), promoting myocardial fibrosis, adverse left ventricular remodeling, and impacting on clinical course and outcome in HCM patients. The aim of study was to assess the prevalence and clinical significance of myocardial ischemia in children with HCM using 99mTc-MIBI single-photon emission computed tomography (SPECT). Ninety-one children with HCM, median age 13.6 years, underwent SPECT evaluation from 2006 to 2017. Imaging was performed at rest and after maximal exercise. Myocardial perfusion defects were identified in 70 children (76.9%; group I), median age 13.8 years. Fixed perfusion defects were evident in 22 of them, while reversible at rest in 48. In 21 children (23.1%; group II), median age 11 years, myocardial perfusion defects were not detected. Patient demographics, echocardiography, resting electrocardiogram (ECG), 24-h Holter ECG, myocardial fibrosis in cardiovascular magnetic resonance imaging, and cardiovascular events were analyzed and compared between the groups. During follow-up at a median of 8.3 years in children with myocardial ischemia, clinical endpoints occurred more often (47 vs. 5;p = 0.02) and more patients reached a clinical endpoint (28 [40%] vs. 3 [14.3%];p = 0.036). In children with myocardial ischemia, myocardial fibrosis was observed with greater frequency. Myocardial perfusion defects may reflect an ischemic process which (1) affects the clinical manifestations and (2) is an important predictor of adverse clinical events and risk of death in children with HCM. Myocardial ischemia in HCM patients frequently correlates with myocardial fibrosis.
Rhizobium and Mycorrhizal Fungal Species Improved Soybean Yield Under Drought Stress Conditions
Authors: Igiehon Ozede N. , Babalola Olubukola O. 
Published: March 2021

AbstractFood insecurity is a serious threat due to the increasing human population particularly in developing countries and may be minimized by the use of microbial inoculants. Also, the problems of excessive use of chemical fertilizers including the fact that most of the fertilizers are relatively non-affordable and that they also contaminate underground and surface water, which can increase the risk of blue baby syndrome in infants and stomach cancer in adults. There is therefore the need to harness a more cost-effective, eco-friendly and beneficial biological agents to improve crops productivity especially under drought conditions. Thus, in this study, the ability of rhizobia species and arbuscular mycorrhizal fungi (AMF) to enhance soybean tolerance to drought stress under water regimens of 100, 70 and 40% field capacity (FC) was investigated. It was observed that co-inoculation of soybean withRhizobiumspp. (R1+R3) as well as withRhizobiumspp. and mycorrhizal consortium (R1+R3MY) had significant impacts (P< 0.05) on soybean leaf relative water content and electrolyte leakage, respectively. The levels of proline increased mainly in microbially amended soybean exposed to drought stress. Plants inoculated with R1+R3MY showed the highest number of spore and % mycorrhization in all the water regimes. At 40% FC, R1+R3MY treatment was found to promote soybean growth compared to the non-inoculated plants. Similarly, at 40% FC, R1+R3MY inoculum had the greatest impacts on soybean pod number, seed number, seed fresh weight, highest seed number per pod and seed dry weight while at 70% water stress, significant impacts of R1MY inoculation were observed on pod number, pod fresh weight and seed dry weight. These results revealed that co-inoculation of rhizobia and mycorrhizal fungi can be harnessed biotechnologically to proffer solution to food insecurity.
Two-scale, non-local diffusion in homogenised heterogeneous media
Authors: Ramírez-Torres Ariel , Penta Raimondo , Grillo Alfio 
Published: March 2021

AbstractWe study how and to what extent the existence of non-local diffusion affects the transport of chemical species in a composite medium. For our purposes, we prescribe the mass flux to obey a two-scale, non-local constitutive law featuring derivatives of fractional order, and we employ the asymptotic homogenisation technique to obtain an overall description of the species’ evolution. As a result, the non-local effects at the micro-scale arecipheredin the effective diffusivity, while at the macro-scale the homogenised problem features an integro-differential equation of fractional type. In particular, we prove that in the limit case in which the non-local interactions are neglected, classical results of asymptotic homogenisation theory are re-obtained. Finally, we perform numerical simulations to show the impact of the fractional approach on the overall diffusion of species in a composite medium. To this end, we consider two simplified benchmark problems, and report some details of the numerical schemes based on finite element methods.
The effects of 12 weeks of static stretch training on the functional, mechanical, and architectural characteristics of the triceps surae muscle–tendon complex
Authors: Longo Stefano , Cè Emiliano , Bisconti Angela Valentina , Rampichini Susanna , Doria Christian , Borrelli Marta , Limonta Eloisa , Coratella Giuseppe , Esposito Fabio 
Published: March 2021

Abstract
Purpose
We investigated the effects of 12 weeks of passive static stretching training (PST) on force-generating capacity, passive stiffness, muscle architecture of plantarflexor muscles.

Methods
Thirty healthy adults participated in the study. Fifteen participants (STR, 6 women, 9 men) underwent 12-week plantarflexor muscles PST [(5 × 45 s-on/15 s-off) × 2exercises] × 5times/week (duration: 2250 s/week), while 15 participants (CTRL, 6 women, 9 men) served as control (no PST). Range of motion (ROM), maximum passive resistive torque (PRTmax), triceps surae architecture [fascicle length, fascicle angle, and thickness], passive stiffness [muscle–tendon complex (MTC) and muscle stiffness], and plantarflexors maximun force-generating capacity variables (maximum voluntary contraction, maximum muscle activation, rate of torque development, electromechanical delay) were calculated Pre, at the 6th (Wk6), and the 12th week (Wk12) of the protocol in both groups.

Results
Compared to Pre, STR ROM increased (P < 0.05) at Wk6 (8%) and Wk12 (23%). PRTmax increased at Wk12 (30%, P < 0.05), while MTC stiffness decreased (16%, P < 0.05). Muscle stiffness decreased (P < 0.05) at Wk6 (11%) and Wk12 (16%). No changes in triceps surae architecture and plantarflexors maximum force-generating capacity variables were found in STR (P > 0.05). Percentage changes in ROM correlated with percentage changes in PRTmax (ρ = 0.62, P = 0.01) and MTC stiffness (ρ = − 0.78, P = 0.001). In CTRL, no changes (P > 0.05) occurred in any variables at any time point.

Conclusion
The expected long-term PST-induced changes in ROM were associated with modifications in the whole passive mechanical properties of the ankle joint, while maximum force-generating capacity characteristics were preserved. 12 weeks of PST do not seem a sufficient stimulus to induce triceps surae architectural changes.
Mortality after cardiopulmonary resuscitation on a medical ICU
Authors: Rezar Richard , Wernly Bernhard , Haslinger Michael , Seelmaier Clemens , Schwaiger Philipp , Pretsch Ingrid , Eisl Maria , Jung Christian , Hoppe Uta C. , Lichtenauer Michael 
Published: March 2021

SummaryBackgroundPerforming cardiopulmonary resuscitation (CPR) and postresuscitation care in the intensive care unit (ICU) are standardized procedures; however, there is evidence suggesting sex-dependent differences in clinical management and outcome variables after cardiac arrest (CA).MethodsA prospective analysis of patients who were hospitalized at a medical ICU after CPR between December 2018 and March 2020 was conducted. Exclusion criteria were age < 18 years, hospital length of stay < 24 h and traumatic CA. The primary study endpoint was mortality after 6 months and the secondary endpoint neurological outcome assessed by cerebral performance category (CPC). Differences between groups were calculated by using U‑tests and χ2-tests, for survival analysis both univariate and multivariable Cox regression were fitted.ResultsA total of 106 patients were included and the majority were male (71.7%). No statistically significant difference regarding 6‑month mortality between sexes could be shown (hazard risk, HR 0.68, 95% confidence interval, CI 0.35–1.34;p = 0.27). Neurological outcome was also similar between both groups (CPC 1 88% in both sexes after 6 months;p = 1.000). There were no statistically significant differences regarding general characteristics, pre-existing diseases, as well as the majority of clinical and laboratory parameters or measures performed on the ICU.ConclusionIn a single center CPR database no statistically significant sex-specific differences regarding post-resuscitation care, survival and neurological outcome after 6 months were observed.
Automatic detection and classification of emotional states in virtual reality and standard environments (LCD): comparing valence and arousal of induced emotions
Authors: Magdin Martin , Balogh Zoltán , Reichel Jaroslav , Francisti Jan , Koprda Štefan , György Molnár 
Published: March 2021

AbstractThe following case study was carried out on a sample of one experimental and one control group. The participants of the experimental group watched the movie section from the standardized LATEMO-E database via virtual reality (VR) on Oculus Rift S and HTC Vive Pro devices. In the control group, the movie section was displayed on the LCD monitor. The movie section was categorized according to Ekman's and Russell's classification model of evoking an emotional state. The range of valence and arousal was determined in both observed groups. Valence and arousal were measured in each group using a Self-Assessment Manikin (SAM). The control group was captured by a camera and evaluated by Affdex software from Affectiva in order to compare valence values. The control group showed a very high correlation (0.92) between SAM and Affdex results. Having considered the Affdex results as a reference value, it can be concluded that SAM participants evaluated their emotions objectively. The results from both groups show that the movie section is supposed to evoke negative emotion. Negative emotion was perceived more intensely than its counterpart, positive emotion. Using virtual reality to evoke negative emotion (anger) has confirmed that VR triggers a significantly stronger intensity of emotion than LCD.
The influence of training level on manual flight in connection to performance, scan pattern, and task load
Authors: Friedrich Maik , Lee Seung Yong , Bates Paul , Martin Wayne , Faulhaber Anja K. 
Published: March 2021

AbstractThis work focuses on the analysis of pilots’ performance during manual flight operations in different stages of training and their influence on gaze strategy. The secure and safe operation of air traffic is highly dependent on the individual performances of the pilots. Before becoming a pilot, he/she has to acquire a broad set of skills by training to pass all the necessary qualification and licensing standards. A basic skill for every pilot is manual control operations, which is a closed-loop control process with several cross-coupled variables. Even with increased automation in the cockpit, the manual control operations are essential for every pilot as a last resort in the event of automation failure. A key element in the analysis of manual flight operations is the development over time in relation to performance and visual perception. An experiment with 28 participants (including 11 certified pilots) was conducted in a Boeing 737 simulator. For defined flight phases, the dynamic time warping method was applied to evaluate the performance for selected criteria, and eye-tracking methodology was utilized to analyze the gaze-pattern development. The manipulation of workload and individual experience influences the performance and the gaze pattern at the same time. Findings suggest that the increase of workload has an increased influence on pilots depending on the flight phase. Gaze patterns from experienced pilots provide insights into the training requirements of both novices and experts. The connection between workload, performance and gaze pattern is complex and needs to be analyzed under as many differing conditions. The results imply the necessity to evaluate manual flight operations with respect to more flight phases and a detailed selection of performance indications.
Vascular endothelial growth factors and angiopoietins as new players in mastocytosis
Authors: Marcella Simone , Petraroli Angelica , Braile Mariantonia , Parente Roberta , Ferrara Anne Lise , Galdiero Maria Rosaria , Modestino Luca , Cristinziano Leonardo , Rossi Francesca Wanda , Varricchi Gilda , Triggiani Massimo , de Paulis Amato , Spadaro Giuseppe , Loffredo Stefania 
Published: March 2021

AbstractMastocytosis is a disorder characterized by the abnormal proliferation and/or accumulation of mast cells in different organs. More than 90% of patients with systemic mastocytosis have a gain-of-function mutation in codon 816 of the KIT receptor on mast cells (MCs). The symptoms of mastocytosis patients are related to the MC-derived mediators that exert local and distant effects. MCs produce angiogenic and lymphangiogenic factors, including vascular endothelial growth factors (VEGFs) and angiopoietins (ANGPTs). Serum concentrations of VEGF-A, VEGF-C, VEGF-D, ANGPT1 and ANGPT2 were determined in 64 mastocytosis patients and 64 healthy controls. Intracellular concentrations and spontaneous release of these mediators were evaluated in the mast cell lines ROSAKIT WTand ROSAKIT D816Vand in human lung mast cells (HLMCs). VEGF-A, ANGPT1, ANGPT2 and VEGF-C concentrations were higher in mastocytosis patients compared to controls. The VEGF-A, ANGPT2 and VEGF-C concentrations were correlated with the symptom severity. ANGPT1 concentrations were increased in all patients compared to controls. ANGPT2 levels were correlated with severity of clinical variants and with tryptase levels. VEGF-A, ANGPT1 and VEGF-C did not differ between indolent and advanced mastocytosis. ROSAKIT WT, ROSAKIT D816Vand HLMCs contained and spontaneously released VEGFs and ANGPTs. Serum concentrations of VEGFs and ANGPTs are altered in mastocytosis patients.
Limited host range in the idiobiont parasitoid Phymastichus coffea, a prospective biological control agent of the coffee pest Hypothenemus hampei in Hawaii
Authors: Yousuf Fazila , Follett Peter A. , Gillett Conrad P. D. T. , Honsberger David , Chamorro Lourdes , Johnson M. Tracy , Giraldo-Jaramillo Marisol , Benavides-Machado Pablo , Wright Mark G. 
Published: March 2021

AbstractPhymastichus coffea LaSalle (Hymenoptera:Eulophidae) is an adult endoparasitoid of the coffee berry borer, Hypothenemus hampei (Ferrari) (Coleoptera:Curculionidae:Scolytinae), which has been introduced in many coffee producing countries as a biological control agent. To determine the effectiveness of P. coffea against H. hampei and environmental safety for release in Hawaii, we investigated the host selection and parasitism response of adult females to 43 different species of Coleoptera, including 23 Scolytinae (six Hypothenemus species and 17 others), and four additional Curculionidae. Non-target testing included Hawaiian endemic, exotic and beneficial coleopteran species. Using a no-choice laboratory bioassay, we demonstrated that P. coffea was only able to parasitize the target host H. hampei and four other adventive species of Hypothenemus: H. obscurus, H. seriatus, H. birmanus and H. crudiae. Hypothenemus hampei had the highest parasitism rate and shortest parasitoid development time of the five parasitized Hypothenemus spp. Parasitism and parasitoid emergence decreased with decreasing phylogenetic relatedness of the Hypothenemus spp. to H. hampei, and the most distantly related species, H. eruditus, was not parasitized. These results suggest that the risk of harmful non-target impacts is low because there are no native species of Hypothenemus in Hawaii, and P. coffea could be safely introduced for classical biological control of H. hampei in Hawaii.
Estimation of MCS intensity for Italy from high quality accelerometric data, using GMICEs and Gaussian Naïve Bayes Classifiers
Authors: Cataldi Laura , Tiberi Lara , Costa Giovanni 
Published: March 2021

AbstractMacroseismic intensity provides a qualitative description of seismic damage. It can be associated with Ground Motion Parameters (GMPs), which are extracted in near real-time from instrumental recordings during an earthquake. Several formulations of this empirical association exist in literature for Italy, mainly focusing on the relationship between intensity expressed on the Mercalli-Cancani-Sieberg (MCS) scale and peak ground acceleration or velocity. They are usually in the form of Ground Motion to Intensity Conversion Equations (GMICEs), which treat intensity as a continuous quantity. We propose an alternative approach, the Gaussian Naïve Bayes (GNB) classifiers, which allows to correctly treat intensity according to its ordinal definition. As a comparison, we also implement a modified version of the standard GMICE approach. We expand the existing database of GMP/MCS-intensity points with new, high-quality accelerometric data recorded in Italy in the period from 2002 to 2016 and resample the database by treating the intermediate intensities with half integer values (which are not meaningful in the MCS description) as both belong to the above and below full integer classes with an assigned weight. As a result, we estimate a new set of regression relations and GNB probability distributions between integer MCS intensity classes and eight GMPs (peak acceleration, velocity, displacement, Arias and Housner intensities, spectral acceleration at 0.3, 1.0 and 3.0 s). Results based on PGA and PGV are the most stable on the whole intensity scale. GNB models score better than GMICEs in terms of performance on unseen data and classification scores.
Changes in the cellulose fiber wall supramolecular structure during the initial stages of chemical treatments of wood evaluated by NMR and X-ray scattering
Authors: Brännvall Elisabet , Larsson P. Tomas , Stevanic Jasna S. 
Published: March 2021

AbstractThe effect of initial stages of pulping of spruce, resembling prehydrolysis and alkaline cooking was studied using CP/MAS 13C-NMR, X-ray scattering, FSP and carbohydrate composition in order to study the impact of the pre-treatments on the fiber wall nanostructure. Removal of fiber wall components, hemicellulose and lignin, increased the fiber wall porosity and induced cellulose fibril aggregation. The effect of temperature and pH in the treatment on cellulose fibril aggregate size appears to be secondary. It is the removal of hemicellulose that has a profound effect on the supramolecular structure of the cellulose fiber wall. As the amount of hemicellulose dissolved from wood increases, the fibril aggregate size determined by NMR increases as well, ranging from 16 to 28 nm. Specifically, a good correlation between the amount of glucomannan in the fiber wall and the fibril aggregate size is seen. The lower the amount of glucomannan, the larger the aggregate size. Glucomannan thus seems to prevent aggregation as it acts as a very efficient spacer between fibrils. Elemental fibril size determined by NMR, was quite similar for all samples, ranging from 3.6 to 4.1 nm. By combining measurement methods, a more well-resolved picture of the structural changes occurring during was obtained.