bluuebunny/crossref_metadata_2025_split huggingface dataset:
Specters of World Literature
Authors: Mattar Karim 
Published: September 2021

This book draws on Edward Said, Aamir Mufti, Jacques Derrida, and world-systems theory to address the institutionalized construct of “world literature” from its origins in Goethe and Marx to the present day. It argues that through its history, this construct has served to incorporate if not annul local literatures and the concept of “local literature” itself, and to universalize the novel, the lyric poem, and the stage play as the only literary forms appropriate to modernity. It demonstrates this thesis through a comparative reading of the reinscription of the classical Arabic-Islamic concept of “adab” as “literature” in the modern, European sense in Egypt, Turkey, and Iran in the 19th to mid-20th centuries. It then turns to the Middle Eastern novel in the global contexts of its production, translation, circulation, and reception today. Through new readings of novels and other literary works by Abdelrahman Munif, Naguib Mahfouz, Orhan Pamuk, Azar Nafisi, Yasmin Crowther, and Marjane Satrapi, and with reference to landmarks of Middle Eastern and world literary history ranging from the Mu‘allaqāt and Alf Layla wa Layla to Don Quixote, it argues that these texts—like “world literature” itself—are constitutively haunted by specters of the literary forms and traditions, of the life-worlds that they expressed, cast aside by modernity. In the case of the Middle Eastern novel, it is adab and all that it encompassed in the classical Arab-Islamic world that is suppressed or othered, but that spectral, yet returns in new, genuinely worldly constellations of form.
Plotting the News in the Victorian Novel
Authors: Valdez Jessica R. 
Published: September 2021

Newspapers are constantly lying in the worlds of Victorian novels, from the false report of John Harmon’s death in Our Mutual Friend (1864-1865) to allegations of extramarital affairs in Phineas Finn (1867-1868). Yet characters continue to believe what they read in the newspaper, assuming that news must be recent, relevant, and true. Victorian novels thus explore the contradictory logic of news: claims to journalistic reality sit uneasily alongside unrepresentative, malicious, or even false news. This book argues that nineteenth-century novels analysed the formal and social workings of news through a shifting series of metaphors, analogies, and plots. By incorporating newspapers and news discourse into their narratives, Victorian novels experimented with the ways that generic and formal qualities might reshape communal and national imaginings.
This book shows that novelists often responded to newspapers by reworking well-known events covered by Victorian newspapers in their fictions. Each chapter addresses a different narrative modality and its relationship to the news: Charles Dickens interrogates the distinctions between fictional and journalistic storytelling, while Anthony Trollope explores novelistic bildung in serial form; the sensation novels of Wilkie Collins and Mary Elizabeth Braddon locate melodrama in realist discourses, whereas Anglo-Jewish writer Israel Zangwill represents a hybrid minority experience. At the core of these metaphors and narrative forms is a theorisation of the newspaper’s influence on society.
Metabolic Engineering of Corynebacterium glutamicum for Production of UDP-N-Acetylglucosamine
Authors: Gauttam Rahul , Desiderato Christian K. , Radoš Dušica , Link Hannes , Seibold Gerd M. , Eikmanns Bernhard J. 
Published: September 2021

Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) is an acetylated amino sugar nucleotide that naturally serves as precursor in bacterial cell wall synthesis and is involved in prokaryotic and eukaryotic glycosylation reactions. UDP-GlcNAc finds application in various fields including the production of oligosaccharides and glycoproteins with therapeutic benefits. At present, nucleotide sugars are produced either chemically or in vitro by enzyme cascades. However, chemical synthesis is complex and non-economical, and in vitro synthesis requires costly substrates and often purified enzymes. A promising alternative is the microbial production of nucleotide sugars from cheap substrates. In this study, we aimed to engineer the non-pathogenic, Gram-positive soil bacterium Corynebacterium glutamicum as a host for UDP-GlcNAc production. The native glmS, glmU, and glmM genes and glmM of Escherichia coli, encoding the enzymes for UDP-GlcNAc synthesis from fructose-6-phosphate, were over-expressed in different combinations and from different plasmids in C. glutamicum GRS43, which lacks the glucosamine-6-phosphate deaminase gene (nagB) for glucosamine degradation. Over-expression of glmS, glmU and glmM, encoding glucosamine-6-phosphate synthase, the bifunctional glucosamine-1-phosphate acetyltransferase/N-acetyl glucosamine-1-phosphate uridyltransferase and phosphoglucosamine mutase, respectively, was confirmed using activity assays or immunoblot analysis. While the reference strain C. glutamicum GlcNCg1 with an empty plasmid in the exponential growth phase contained intracellularly only about 0.25 mM UDP-GlcNAc, the best engineered strain GlcNCg4 accumulated about 14 mM UDP-GlcNAc. The extracellular UDP-GlcNAc concentrations in the exponential growth phase did not exceed 2 mg/L. In the stationary phase, about 60 mg UDP-GlcNAc/L was observed extracellularly with strain GlcNCg4, indicating the potential of C. glutamicum to produce and to release the activated sugar into the culture medium. To our knowledge, the observed UDP-GlcNAc levels are the highest obtained with microbial hosts, emphasizing the potential of C. glutamicum as a suitable platform for activated sugar production.
Novel Molecular Subtypes and Related Score Based on Histone Acetylation Modification in Renal Clear Cell Carcinoma
Authors: Wang Shichao , Xiang Ting , Yu Ling , Wen Junmao , Liu Fang , Yang Dong , Wu Wei , Hu Ling 
Published: September 2021

Background: Histone acetylation modification has been found to be correlated the development of renal carcinoma; however, its role in clear cell renal carcinoma (ccRCC) remains to be investigated. Thus, this study aimed to identify the molecular subtypes and establish a relevant score based on histone acetylation modification in ccRCC.Methods: Gene expression and mutation data were retrieved from The Cancer Genome Atlas database. Molecular subtypes were identified by unsupervised clustering based on histone acetylation regulators expression, and the molecular and clinical characteristics including survival, tumor microenvironment, gene set variation, immune cell infiltration, and immune checkpoints in each subtype were investigated. Next, we employed univariate Cox analysis to analyze these genes and established acetylation-related score by lasso regression analysis. Furthermore, we investigated the differences including survival, signaling pathways, mutational landscape, and tumor mutation burden (TMB) between high-risk and low-risk groups. The established score was validated by receiver operating curve and univariate and multivariate Cox regression analyses. We also established a nomogram including acetylation score, age, gender, grade, and stage and verified it by decision curve analysis and calibration plot. The E-MTAB-1980 cohort from the ArrayExpress database was employed as a reference to validate the established score.Results: Thirty-three types of histone acetylation regulators were employed in this study, and two clusters were identified. The two clusters presented significant differences in survival, tumor microenvironment, immune cell infiltration, immune checkpoints, and signaling pathways. Furthermore, an acetylation-related score, composed of six genes (BRD9, HDAC10, KAT2A, KAT5, BRDT, SIRT1, KAT6A, HDAC5), was verified to be significantly associated with prognosis and TMB. Thus, the established scores were successfully verified by the validated cohort, and the nomogram was constructed and successfully validated.Conclusion: The identification of the histone acetylation-related subtypes and score in our study may help reveal the potential relation between histone acetylation and immunity and provide novel insights for the development of individualized therapy for ccRCC.
Interaction Between Functionally Activate Endometrial Microbiota and Host Gene Regulation in Endometrial Cancer
Authors: Chen Peigen , Guo Yingchun , Jia Lei , Wan Jing , He TianTian , Fang Cong , Li Tingting 
Published: September 2021

Objective: In this study, we mainly explored two questions: Which microorganisms were functionally active in the endometrium of patients with endometrial cancer (EC)? What kind of response did the human host respond to functionally active microorganisms?Methods: Nine endometrial cancer patients and eight normal subjects were included in this study. HMP Unified Metabolic Analysis Network 3 (HUMAnN3) was used to obtain functional information of microorganisms. In addition, metaCyc-based GSEA functional enrichment analysis was used to obtain information on the metabolic pathways of the human host. At the same time, the O2PLS model and Spearman correlation analysis were used to analyze the microorganisms–host interaction.Results: With the novel metatranscriptome analysis pipeline, we described the composition of more than 5,000 functionally active microorganisms and analyzed the difference in microorganisms between the EC and the normal group. Our research found that these microorganisms were involved in part of the metabolic process of endometrial cancer, such as 6-sulfo-sialyl Lewis x epitope, N-acetyl-beta-glucosaminyl. In addition, the host–microbiota crosstalk of EC endometrium also included many biological processes, mainly functions related to tumor migration and the Apelin signaling pathway.Conclusion: The functionally active microorganisms in the EC endometrium played an essential role in the occurrence and migration of tumors. This meant that functionally active microorganisms could not be ignored in the treatment of endometrial cancer. This study helped to better understand the possible role of endometrial functional, active microorganisms in the occurrence and development of EC in patients with endometrial cancer and provided new information for new attempts to treat EC.
Molecular Dynamics Calculation on the Adhesive Interaction Between the Polytetrafluoroethylene Transfer Film and Iron Surface
Authors: Zuo Zhen , Liang Lifen , Bao Qianqian , Yan Pengtao , Jin Xin , Yang Yulin 
Published: September 2021

During the friction process, the polytetrafluoroethylene (PTFE) adhered on the counterpart surface was known as the PTFE transfer film, which was fundamental to the lubricating performance of the PTFE. However, the adhesive interaction between the iron surface and the adhered PTFE transfer film is still unclear. In present study, molecular dynamics simulations were used to reveal the adhesive interaction between the iron surface and PTFE transfer film. Based on the atomic trajectories obtained through the molecular dynamics, the interaction energy, concentration profile, radial distribution function, and mean square displacement were calculated to analyze the structure of the interface. The negative values of the interaction energy demonstrated the adhesive interaction between the PTFE transfer film and Fe surfaces, resulting in the accumulation of the PTFE transfer film on the Fe surface. Among the (100) (110), and (111) surfaces of α-Fe (110) surface owns the strongest adhesive interaction with the PTFE transfer film. Compared with the original PTFE molecule, the chain broken PTFE, hydroxyl substituted PTFE, and carbonyl substituted PTFE exhibited stronger adhesive interaction with Fe surface. The adhesive interaction between the PTFE transfer film and Fe surfaces was mainly originated from the Fe atoms and the F atoms of the adsorbate PTFE transfer film, which was governed by the van der Waals force. The bonding distance between the Fe atom and the F atom of the adsorbate PTFE transfer film is around 2.8 Å. Moreover, the chain broken of PTFE molecule and the rise of temperature can remarkably increase the mobility of polymer chains in the interface system.
Symmetric Projection Attractor Reconstruction: Sex Differences in the ECG
Authors: Lyle Jane V. , Nandi Manasi , Aston Philip J. 
Published: September 2021

Background: The electrocardiogram (ECG) is a key tool in patient management. Automated ECG analysis supports clinical decision-making, but traditional fiducial point identification discards much of the time-series data that captures the morphology of the whole waveform. Our Symmetric Projection Attractor Reconstruction (SPAR) method uses all the available data to provide a new visualization and quantification of the morphology and variability of any approximately periodic signal. We therefore applied SPAR to ECG signals to ascertain whether this more detailed investigation of ECG morphology adds clinical value.Methods: Our aim was to demonstrate the accuracy of the SPAR method in discriminating between two biologically distinct groups. As sex has been shown to influence the waveform appearance, we investigated sex differences in normal sinus rhythm ECGs. We applied the SPAR method to 9,007 10 second 12-lead ECG recordings from Physionet, which comprised; Dataset 1: 104 subjects (40% female), Dataset 2: 8,903 subjects (54% female).Results: SPAR showed clear visual differences between female and male ECGs (Dataset 1). A stacked machine learning model achieved a cross-validation sex classification accuracy of 86.3% (Dataset 2) and an unseen test accuracy of 91.3% (Dataset 1). The mid-precordial leads performed best in classification individually, but the highest overall accuracy was achieved with all 12 leads. Classification accuracy was highest for young adults and declined with older age.Conclusions: SPAR allows quantification of the morphology of the ECG without the need to identify conventional fiducial points, whilst utilizing of all the data reduces inadvertent bias. By intuitively re-visualizing signal morphology as two-dimensional images, SPAR accurately discriminated ECG sex differences in a small dataset. We extended the approach to a machine learning classification of sex for a larger dataset, and showed that the SPAR method provided a means of visualizing the similarities of subjects given the same classification. This proof-of-concept study therefore provided an implementation of SPAR using existing data and showed that subtle differences in the ECG can be amplified by the attractor. SPAR's supplementary analysis of ECG morphology may enhance conventional automated analysis in clinically important datasets, and improve patient stratification and risk management.
Reference Values of Right Ventricular Volumes and Ejection Fraction by Three-Dimensional Echocardiography in Adults: A Systematic Review and Meta-Analysis
Authors: Wang Shitong , Wang Shuyu , Zhu Qing , Wang Yonghuai , Li Guangyuan , Kong Fanxin , Yang Jun , Ma Chunyan 
Published: September 2021

Objective: This study was conducted in order to determine the reference values for right ventricular (RV) volumes and ejection fraction (EF) using three-dimensional echocardiography (3DE) and to identify sources of variance through a systematic review and meta-analysis.Methods: This systematic review was preregistered with the International Prospective Register of Systematic Reviews (https://www.crd.york.ac.uk/PROSPERO/) (CRD42020211002). Relevant studies were identified by searches of the PubMed, Embase, and Cochrane Library databases through October 12, 2020. Pooled reference values were calculated using the random-effects model weighted by inverse variance. Meta-regression analysis and Egger's test were used to determine the source of heterogeneity. A subgroup analysis was performed to evaluate the reference values across different conditions.Results: The search identified 25 studies of 2,165 subjects. The mean reference values were as follows: RV end-diastolic volume, 100.71 ml [95% confidence interval (CI), 90.92–110.51 ml); RV end-systolic volume, 44.19 ml (95% CI, 39.05–49.33 ml); RV end-diastolic volume indexed, 57.01 ml/m2 (95% CI, 51.93–62.08 ml/m2); RV end-systolic volume indexed, 25.41 ml/m2 (95% CI, 22.58–28.24 ml/m2); and RVEF, 56.20% (95% CI, 54.59–57.82%). The sex- and age-specific reference values were assessed according to the studies reporting the values of different sexes and age distributions, respectively. In addition, the vendor- and software-specific reference values were analyzed. The meta-regression analysis revealed that sex, frame rate, pulmonary artery systolic pressure, and software packages were associated with variations in RV volumes (P &lt; 0.05). Inter-vendor and inter-software discrepancies may explain the variability of RVEF.Conclusions: The reference values for RV volumes and RVEF using 3DE were assessed. The confounders that impacted the variability in RV volumes or RVEF contained the sex, frame rate, pulmonary artery systolic pressure, inter-vendor discrepancies, and inter-software discrepancies.
The Extended Continental Crust West of Islas Marías (Mexico)
Authors: Núñez Diana , Acosta-Hernández Jorge A. , Escalona-Alcázar Felipe de Jesús , Pilia Simone , Núñez-Cornú Francisco Javier , Córdoba Diego 
Published: September 2021

The crustal structure around the Islas Marías Archipelago has been debated for a long time. An important unresolved question is where the Rivera-North American plate subduction ends and the Tamayo fracture zone begins, from SE to NW. Results from the TsuJal project have shed light on the northwesternmost part of the Jalisco block structure. It is now clear that Sierra de Cleofas and the Islas Marías Escarpment comprise the northwestern continuation of the Middle America trench. However, other questions remain. In this paper, we present the structure of the shallow and deep crust and the upper mantle of the Islas Marías western region through the integration of multichannel seismic reflection, wide-angle seismic bathymetric and seismicity data, including records of an amphibious seismic network, OBS, and portable seismic stations, purposely deployed for this project, providing an onshore-offshore transect of 310 km length. Our findings disclose new evidence of the complex structure of the Rivera plate that dips 8°–9° underneath the NW Jalisco block as revealed by two seismic profiles parallel to the Islas Marías Escarpment. Moreover, we find five sedimentary basins and active normal faults at the edges of tectonic structures of the E-W oriented West Ranges and the N-S trending Sierra de Cleofas. Furthermore, the Sierra de Cleofas is the beginning of the active subduction of the Rivera plate beneath North America. The oceanic crust thickens and submerges towards the south while is coupled with the continental crust, from 6 km at the northern ends of the seismic profiles to 15 km in the contact region and 24 km at the coast and southern ends of them. The continental Moho was not fully characterized because of the geometry of the seismic transects, but a low-velocity layer associated with Rivera Plate subduction was observed beneath the Jalisco Block. Our results constrain the complexity of the area and reveal new structural features from the oceanic to continental crust and will be pivotal to assess geohazards in this area.
Small-Scale Volcanic Structures of the Aeolian Volcanic Arc Revealed by Seismic Attenuation
Authors: Castro-Melgar Ignacio , Prudencio Janire , Cannata Andrea , Del Pezzo Edoardo , Ibáñez Jesús M. 
Published: September 2021

We present the first two-dimensional (2-D) spatial distribution of seismic scattering and intrinsic attenuation beneath the Aeolian Islands arc. The Aeolian Islands archipelago represents one of the best examples of a small dimension volcanic island arc characterised by the alternation of different structural domains. Using the seismic wave diffusion model as the basis for the analysis, and using data from an active seismic experiment (TOMO-ETNA), we analysed more than 76,700 seismic paths marked by epicentre-seismic station pairs. Based on frequencies of 4–24 Hz, we identified high regional attenuation, comparable with other volcanic areas of the world. We used two different seismogram lengths, reflecting two different sampling depths, which allowed us to observe two different attenuative behaviours. As in most volcanic regions, scattering attenuation predominates over intrinsic attenuation, but some characteristics are area-specific. Volcanic structures present the highest contribution to scattering, especially in the low frequency range. This behaviour is interpreted to reflect the small size of the islands and the potentially relatively small size of individual magmatic feeding systems. In addition, strong scattering observed in one zone is associated with the northernmost part of the so-called Aeolian-Tindari-Letojanni fault system. In contrast, away from the volcanic islands, intrinsic attenuation dominates over scattering attenuation. We interpret this shift in attenuative behaviour as reflecting the large volume of sedimentary material deposited on the seabed. Owing to their poorly consolidated nature, sediments facilitate intrinsic attenuationviaenergy dissipation, but in general present high structural homogeneity that is reflected by low levels of scattering. Our results show that this region is not underlain by a large volcanic structural complex such as that beneath nearby Mt. Etna volcano. Instead, we observe dimensionally smaller and isolated subsurface volcanic structures. The identification of such features facilitates improved geological interpretation; we can now separate consolidated marine structures from independent subsurface volcanic elements. The results of this study provide a model for new research in similar regions around the world.
Case Report: Candidate Genes Associated With Prenatal Ultrasound Anomalies in a Fetus With Prenatally Detected 1q23.3q31.2 Deletion
Authors: Song Jiahao , Zhang Qian , Lu Bing , Gou Zhongshan , Wang Ting , Tang Hui , Xiang Jingjing , Jiang Wei , Deng Xuedong 
Published: September 2021

Background: Patients with deletions involving the long arm of chromosome 1 are rare, and the main aim of this study was to refine the genotype-phenotype correlation.Case Report: In this report, a 28-year-old pregnant woman, gravida 2 para 1, at 25+4 weeks of gestation underwent ultrasound examination in our institute. The ultrasonographic findings of the fetus were as follows: (1) fetal growth restriction; (2) cleft lip and palate; (3) bilateral renal hypoplasia; (4) lateral ventriculomegaly; (5) single umbilical artery; (6) absent stomach; (7) coronary sinus dilatation with persistent left superior vena cava, ventricular septal defect and unroofed coronary sinus syndrome. Chromosomal microarray analysis of amniotic fluid from the fetus revealed a 28.025 Mb deletion in 1q23.3q31.2, spanning from position 164,559,675 to 192,584,768 (hg19).Conclusion: Genotype-phenotype correlation might improve prenatal diagnosis of fetuses with chromosome 1q deletion. PBX1 could be a candidate gene for fetal growth restriction, renal hypoplasia and congenital heart disease. Fetal growth restriction was accompanied by decreased renal volume in the fetus. Combined with ultrasonic examination, the application of chromosomal microarray analysis will provide accurate prenatal diagnosis.