bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic activity around shallow plate boundary near westernmost Nankai Trough revealed by ocean bottom seismometer observation
Authors: Hu Ching-Yu , Shinohara Masanao , Yamashita Yusuke , Tonegawa Takashi , Yamada Tomoaki , Akuhara Takeshi , Mochizuki Kimihiro 
Published: December 2024

AbstractThe Nankai Trough region has a history of devastating earthquakes. The Hyuga-nada region is situated in the westernmost Nankai Trough and has not experienced an earthquake exceeding magnitude 8. It is expected that there is a difference in a coupling between the subducting Philippine Sea Plate and the overriding plate. The region is known for its active region of low-frequency tremors and very low-frequency earthquakes. Several long-term ocean bottom seismometer (LTOBS) networks were deployed to monitor seismic activities in the region to reveal the characteristics of seismicity in the study region. Seafloor seismic observations were conducted on the seafloor in the Hyuga-nada region with periods of 2015–2016, 2017–2018, and 2022. Initially, the hypocenters of regular earthquakes were determined by using a location program that integrated absolute travel times and a 1-D velocity structure. Station corrections for travel times were applied to compensate for structural heterogeneity just beneath individual LTOBS. Subsequently, events were relocated using a double-difference technique to enhance the accuracy of the location. Focal mechanisms were estimated using the polarity data of the first arrivals. Comparison with a plate model indicated that these earthquakes occurred within the subducting Philippine Sea Plate. From the spatial–temporal distribution, hypocenters of earthquakes were concentrated in a small region with a size of a few km and occurred within a few days. We could clearly distinguish swarm activities from regular activities. During the observation period, there were two swarm activities in the study area. Fault plane solutions of regular events except swarms, are dominant with a normal fault type mechanism. On the other hand, swarms had a small number of events with a normal fault type. The swarm activities started slightly later than the very low frequency earthquake (VLFE) activities. The regions of activity for the swarms and the VLFE seemed to generally overlap in consideration of the low spatial resolution of the VLFE locations.
Graphical Abstract
Inhibition of microRNA-660-5p decreases breast cancer progression through direct targeting of TMEM41B
Authors: Villarreal-García Valeria , Estupiñan-Jiménez José Roberto , Gonzalez-Villasana Vianey , Vivas-Mejía Pablo E. , Flores-Colón Marienid , Ancira-Moreno Irma Estefanía , Zapata-Morín Patricio Adrián , Altamirano-Torres Claudia , Vázquez-Guillen José Manuel , Rodríguez-Padilla Cristina , Bayraktar Recep , Rashed Mohamed H. , Ivan Cristina , Lopez-Berestein Gabriel , Reséndez-Pérez Diana 
Published: December 2024

Abstract
Background
Breast cancer is the most prevalent cancer among women worldwide. Most breast cancer-related deaths result from metastasis and drug resistance. Novel therapies are imperative for targeting metastatic and drug-resistant breast cancer cells. Accumulating evidence suggests that dysregulated microRNAs (miRNAs) promote breast cancer progression, metastasis, and drug resistance. Compared with healthy breast tissue, miR-660-5p is notably overexpressed in breast cancer tumor tissues. However, the downstream effectors of miR-660-5p in breast cancer cells have not been fully elucidated. Our aim was to investigate the role of miR-660-5p in breast cancer cell proliferation, migration, invasion, and angiogenesis and to identify its potential targets.

Results
Our findings revealed significant upregulation of miR-660-5p in MDA-MB-231 and MCF-7 cells compared with MCF-10 A cells. Furthermore, inhibiting miR-660-5p led to notable decreases in the proliferation, migration, and invasion of breast cancer cells, as well as angiogenesis, in HUVEC cells. Through bioinformatics analysis, we identified 15 potential targets of miR-660-5p. We validated TMEM41B as a direct target of miR-660-5p via Western blot and dual-luciferase reporter assays.

Conclusions
Our study highlights the upregulation and involvement of miR-660-5p in breast cancer cell proliferation, migration, invasion, and angiogenesis. Additionally, we identified TMEM41B as a direct target of miR-660-5p in breast cancer cells.
Seismic performance of round-end hollow RC tall bridge piers considering to higher-order vibration mode effect
Authors: Liang Xu , Shao Changjiang , Han Qiang 
Published: December 2024

AbstractRound-end hollow reinforced concrete (RC) tall piers have been widespreadly utilized for railway bridges in river valleys and mountainous regions. The post-earthquake damage state of such bridge piers differs significantly from that of traditional short-to-medium piers. To investigate the seismic performance and failure mode of RC round-end hollow tall piers, a finite element model was developed using the OpenSees platform and calibrated against previous test results. Subsequently, incremental dynamic analysis (IDA) and modal pushover analysis (MPA) were conducted to obtain bending moment and curvature distributions as well as damage ranges for piers subjected to different intensities of ground motion. The results indicate that: The RC round-end hollow tall piers subjected to strong ground motions can crack up to 75% and 80% of its height according to IDA and MPA, respectively. The MPA incorporating mode coupling up to the third order is capable of predicting crack distribution of the pier as demonstrated in this study. Furthermore, it is recommended that the damage range of the pier be considered as a primary control indicator in seismic design.
Optimizing Mainstreaming of Genetic Testing in Parallel With Ovarian and Endometrial Cancer Tumor Testing: How Do We Maximize Our Impact?
Authors: Liu Ying L. , Sia Tiffany Y. , Varice Nancy , Wu Michelle , Byrne Maureen , Khurram Aliya , Kemel Yelena , Sheehan Margaret , Galle Jesse , Sabbatini Paul , Brown Carol , Roche Kara Long , Chi Dennis , Solit David B. , Mueller Jennifer , Stadler Zsofia K. , Hamilton Jada G. , Aghajanian Carol , Abu-Rustum Nadeem R. 
Published: December 2024

PURPOSE
Although germline genetic testing (GT) is recommended for all patients with ovarian cancer (OC) and some patients with endometrial cancer (EC), uptake remains low with multiple barriers. Our center performs GT in parallel with somatic testing via a targeted sequencing assay (MSK-IMPACT) and initiates testing in oncology clinics (mainstreaming). We sought to optimize our GT processes for OC/EC.

METHODS
We performed a quality improvement study to evaluate our GT processes within gynecologic surgery/medical oncology clinics. All eligible patients with newly diagnosed OC/EC were identified for GT and tracked in a REDCap database. Clinical data and GT rates were collected by the study team, who reviewed data for qualitative themes.

RESULTS
From February 2023 to April 2023, we identified 116 patients with newly diagnosed OC (n = 57) and EC (n = 59). Patients were mostly White (62%); English was the preferred language for 90%. GT was performed in 52 (91%) patients with OC (seven external, 45 MSK-IMPACT) and in 44 (75%) patients with EC (three external, 41 MSK-IMPACT). GT results were available within 3 months for 100% and 95% of patients with OC and EC, respectively. Reasons for not undergoing GT included being missed by the clinical team where there was no record that GT was recommended, feeling overwhelmed, financial and privacy concerns, and language barriers. In qualitative review, we found that resources were concentrated in the initial visit with little follow-up to encourage GT at subsequent points of care.

CONCLUSION
A mainstreaming approach that couples somatic and germline GT resulted in high testing rates in OC/EC; however, barriers were identified. Processes that encourage GT at multiple care points and allow self-directed, multilingual digital consenting should be piloted.
A Comprehensive Review of Sarcoidosis: From Clinical Manifestations to Management Strategies
Authors: Śpiołek Olga , Siwiec Jan , Słowikowska Aleksandra , Teofilak Mateusz , Szatkowska Julia , Smyl Natalia , Sztyler-Krąkowska Marcelina , Wąsowicz Agnieszka , Kędziora Franciszek , Fabian Dariusz 
Published: December 2024

Introduction and purpose: Sarcoidosis is a complex, multi – system disease characterized by the formation of non – caseating granulomas that can affect nearly every organ in the body, though lungs and lymph nodes are the most commonly involved. The disease's clinical presentation is highly variable, ranging from asymptomatic cases to severe, organ-threatening manifestations, with significant implications for diagnosis and treatment. The aim of this study is to present current state of knowledge on clinical features, etiology, diagnosis and treatment methods of sarcoidosis.
Materials and methods: The review is based on the analysis of literature available on Pubmed, Google Scholar and UpToDate databases. To search for relevant scientific content the following keywords were used: sarcoidosis, symptoms, etiology, diagnosis, treatment, neurosarcoidosis, cutaneous sarcoidosis, cardiac sarcoidosis, Löfgren syndrome.
Conclusions: Despite numerous studies, the cause of sarcoidosis still remains unknown, which leaves a field for researchers for further investigation. Diagnosis of sarcoidosis is challenging, it typically involves histological confirmation through biopsy, supported by imaging studies, laboratory tests and need to exclude other causes. Treatment is limited, focused on alleviating the symptoms and preventing organ failure, therefore further research into more effective or targeted therapies is advisable.
Episodic and chronic migraine - treatment and risk factors - A literature review
Authors: Skrzypek Jakub , Jagoda Niewiadomska  , Borys Bondos  , Aleksandra Stępień  , Alicja Paluch  , Aleksandra Niekra  , Łukasz Fussek  , Robert Kochan  , Ewelina Wieczorek  , Kacper Lee  
Published: December 2024

Abstract

Introduction and objective
Migraine is a chronic paroxysmal neurological disease characterised by attacks of moderate to severe headache and accompanying symptoms such as hypersensitivity to light and sound and gastrointestinal disturbances such as nausea and vomiting, among others. In some people, an attack of pain is preceded by a migraine aura - visual disturbances, numbness, tingling and even muscle weakness. Treatment includes medications taken as a temporary measure (at the onset of an attack) and as a prophylactic measure. The aim of this study is to systemasise information about chronic migraine and to raise awareness about this disease among health care workers and patients
Brief description of the state of knowledge
Migraine is a recurrent, usually unilateral, throbbing headache. A migraine usually lasts between 4 and 72 hours. It is characterised by varying degrees of severity and frequency of occurrence. The pain is exacerbated by emotion or physical exertion. There is photophobia, hypersensitivity to sounds (phonophobia) and odours (osmophobia), and nausea and vomiting occur. Sometimes before a migraine episode occurs, a so-called aura - occurring in 10% of migraine cases may appear, in the form of paresthesias, visual field loss, appearance of gloom, paresis, aphasia. Chronic migraine is a headache that occurs for at least 15 days per month, at least 8 of which are days when the headache has the characteristics of migraine pain as described below or is relieved by prescription anti-migraine medication. There are many triggers for migraine, which include genetic, environmental and personal factors. Chronic migraine severely reduces the quality of life of affected patients, therefore it is important to raise awareness of currently available methods for its diagnosis and treatment
The impact of Schistosoma blood fluke infection on the development of bladder cancer
Authors: Boszczyk Piotr , Wrzesińska Kinga 
Published: December 2024

Introduction and purpose
Schistosomiasis is a significant health problem, particularly in countries in Africa. The disease is caused by blood flukes of the genus Schistosoma. There are five main species. Most infections are asymptomatic. Schistosomiasis can contribute to the development a lot of diseases.
The aim of this article is to examine the impact of schistosomiasis on the human body, with particular focus on bladder cancer.
Brief description of the state of knowledge
Schistosoma are parasitic flatworms whose life cycle involves humans as the definitive host and freshwater snails as intermediate hosts. The cercarial larvae penetrate the human skin. Adult parasites lay eggs in the mucous membranes, causing inflammation and granulomatous reactions. Chronic schistosomiasis leads to tissue fibrosis, portal hypertension, squamous cell carcinoma of the bladder. Acute infection presents with Katayama fever. Diagnosis is based on detecting eggs in urine or stool, as well as serological tests. Treatment includes praziquantel, often supplemented with corticosteroids. Prevention involves avoiding contact with contaminated water. Untreated schistosomiasis can lead to serious complications, including bladder cancer.
Material and methods:Literature available in the PubMed database was reviewed using the following keywords: schistosomiasis; bladder cancer; Schistosoma haematobium; bilharzia; blood fluke.
Summary
Schistosomiasis induces bladder cancer as a result of the chronic inflammatory condition in the urinary tract. The dominant histological type is SCC. Bladder cancer resulting from schistosomiasis is characterized by a younger age of onset and more advanced clinical stages. In the case of bilharzia detection, eradication of the parasite is recommended to prevent the development of cancer.
Evaluation of the efficacy of apoE gene transfection
Authors: Białoszycka Żanna , Białoszycka Monika , Pachevska Alisa , Istoshyn Valerij , Biloshytska Alina , Simonova Irina 
Published: December 2024

Introduction: Pathology of organs of the male reproductive system remains one of the most urgent problems of modern medicine, which is associated not only with patients’ impaired quality of life, but also with high rates of male infertility, which tends to increase.

The aim: To evaluate the efficacy of apoE gene transfection on the morphofunctional state of rat testes in experimental atherosclerosis.

Materials and methods: The study was conducted on 30 sexually mature male rats weighing 150-170 grams. Experimental animals were divided into 3 groups. Group 1 - intact animals. Group 2 – animals with experimental atherosclerosis; Group 3-animals with experimental atherosclerosis, which were intramuscularly injected with the apolipoprotein E gene at a dose of 50 μg of DNA per animal on the first day of modeling atherosclerosis. To study the efficiency of apolipoprotein E gene transfection on morphofunctional changes in testes, the following research methods were used: 1) histological; 2) biochemical; 3) reverse transcriptase PCR diagnostic method.

Results and discussion. Experimental cholesterol loading leads to impaired lipid metabolism, decreased serum testosterone levels, degenerative and dystrophic changes in the testis of experimental rats, which is manifested by luminal occlusion of blood vessels, overgrowth of connective tissue in the organ interstitium, decreased number and qualitative change of Sertoli and Leydig cells, as well as spermatogenic epithelium thinning and inhibition of gamete maturation process in it.

Conclusions: intramuscular transfection of the apoE gene inhibits lipid metabolism disorders and has a positive effect on the morphofunctional state of the testes of experimental animals.
Immunological Abnormalities In PCOS
Authors: Barcińska Joanna Maria , Ostrowska-Czyżewska Aleksandra , Szwed Dominika 
Published: December 2024

PCOS (Polycystic Ovary Syndrome) is a condition associated with irregular ovulation, hyperandrogenism and metabolic disturbances. It affects 10-15% of reproductive ages and it is a common reason for infertility. The basis of PCOS is chronic low-grade inflammation, which is expressed by an increase in inflammatory biomarkers such as CRP, IL6, IFN gamma, TNF alpha, IL10, 17,18 MCP-1 and an increase in the percentage of lymphocytes especially Th1 and macrophages, eosinophils compared to the healthy population. The hormonal imbalances in PCOS may contribute to dysregulation of the immune system, leading to the production of a diverse range of autoantibodies for a spectrum of systemic connective tissue diseases, lupus erythematosus, scleroderma, dermatomyositis, polymyositis, and Sjögren's syndrome. This article reviews the results of previous research on this topic. It was prepared to summarize the latest knowledge about immunological abnormalities in PCOS and to define new therapeutic drug action points.
The Impact of Childhood Obesity on Mental Health: A Comprehensive Review
Authors: Spychalski Jan , Musiał Mikołaj , Spychalska Maria , Dylik Adrianna , Gryczyńska Weronika , Grochowska Wiktoria , Kaczmarek Mikołaj , Krawczak Łukasz , Gulaczyk Hanna 
Published: December 2024

Introduction: Obesity and overweight are among the main health issues affecting the child population in developed countries today. Excess body weight is observed in 29.7% of boys and 14.3% of girls aged 11 to 16 years. Studies reveal that childhood overweight increases the odds of having mental disorders in adolescence compared to children with a normal body weight.
Aim of the study: The aim of this study is to analyse the available literature in order to examine the impact of childhood obesity on mental disorders such as depression, anxiety, ADHD, eating disorders and schizophrenia,
Materials and methods: Comprehensive review of the literature available on PubMed, Google Scholar, Scopus database by searching the keywords “obesity”, “overweight”, “ mental health”, “childhood”, “mood disorders” “psychiatric disorders”, “anxiety”, “depression”, “eating disorders”, “ADHD”
Results and conclusion: Childhood obesity is a growing global problem with physical and health consequences. It is associated with various factors such as social stigma, neurological imbalances or malfunction and other environmental factors related to obesity. It contributes to the growth of depression, ADHD, anxiety, eating disorders, OCD and even schizophrenia. Preventing and treating obese or overweight children have to be done, by affecting both physical and mental health.
Understanding the Educational and Social Difficulties in Children with Hemifacial Microsomia – A Literature Review
Authors: Pniak Michał , Miklis Paweł , Mawlichanów Maciej , Ciesielska Aleksandra , Sieradzka Aleksandra , Szerej Krzysztof , Czaplińska-Paszek Zofia , Kot Alicja , Wojtczak Marta , Myśliwiec Natalia , Róźycki Adrian 
Published: December 2024

Introduction: Hemifacial microsomia (HFM) is a congenital craniofacial defect, the second most common after cleft lip and palate. It is characterized by a wide range of symptoms, including mandibular hypoplasia, ear anomalies, and soft tissue defects. Patients may experience difficulties in learning, communication, and social relationships, which affect their quality of life and self-esteem. Study aims to evaluate the impact of defect on the neurodevelopmental and psychosocial outcomes in affected children.
Materials and methods: Materials for the review were selected based on an analysis of publications published in the last 20 years.
Results: In HFM patients with microtia, mandibular hypoplasia, young maternal age, and additional developmental anomalies, worse outcomes were observed in verbal, non-verbal, and academic skills. Studies on emotional functioning demonstrated a similar level of behavioral adjustment compared to control groups. Adolescents with HFM exhibited a lower tendency toward aggression and rule-breaking. Social problems, such as less frequent contact with peers or rejection by the group, were more common. This was particularly true for children with microtia and mandibular hypoplasia.
Discussion: New studies emphasize that although some young children initially do not exhibit neurological or language deficits, there is an increased risk of educational and psychosocial difficulties in later life. Attention should be paid to patients with mandibular hypoplasia, microtia, and additional defects. Negative experiences in peer relationships and hearing loss may further adversely affect self-esteem and social functioning.
Conclusions: HFM can affect the neurological and psychosocial development of children, especially in language and educational areas. Early intervention, assessment of psychosocial problems, provision of appropriate educational resources, and psychological support are crucial to improving patients' quality of life.
Effectiveness of lower limb arterial angioplasty
Authors: Szuciak Anna , Talarek Konrad , Szewczyk Julia , Świta Michał , Skierkowski Bartosz , Drelichowska Alicja , Ciszewski Przemysław , Azierski Michał , Pikor Damian 
Published: December 2024

Introduction: Over 200 million individuals worldwide suffer with peripheral artery disease (PAD). The disease makes it difficult to function properly by limiting walking and physical activity, which also translates into a reduced quality of life.
Purpose of the Study: The purpose of this review is to evaluate the effectiveness of lower limb angioplasty as a treatment to restore arterial patency, improve the patient's quality of life and reduce complications.
Methodology: A comprehensive search of databases was conducted from 2016, using PubMed, Scopus and Google Scholar, using keywords such as ”angioplasty”, “peripheral artery disease”, “revascularization”, “endovascular intervention”, “atherosclerosis, “quality of life”.
Results: Angioplasty and bypass surgery showed comparable amputation-free survival at two years, though bypass surgery improved overall survival by approximately seven months. Bypass surgery had significantly higher rates of infection compared to angioplasty, leading to increased hospital stays and associated costs. Socioeconomic status significantly influenced outcomes, with lower status relating to higher amputation rates. No significant superiority was observed between bypass surgery and angioplasty in many studies, though treatment choice should be guided by patient condition.
Conclusions: Angioplasty is a safe and effective way to treat PAD can help alleviate the growing global burden of the disease and reduce bed occupancy and improve productivity.