bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lysophosphatidic Acid Receptor 6: A Prognostic Biomarker for Lung Adenocarcinoma via Correlating Immune Infiltration
Authors: He Jian , Meng Mei , Wang Hui 
Published: July 2021

Abstract
Background

LPAR6 is the most recently determined GPCR of LPA, and very few of study have demonstrated the performance of LPAR6 in cancers. Moreover, the relationship of LPAR6 to prognosis potential and tumor infiltration immune cells in different cancers still unclarified.
Methods

The mRNA expression of LPAR6 and its clinical characteristics were evaluated on various databases. The association between LPAR6 and immune infiltrates of various types of cancer were investigated via TIMER. IHC for LPAR6 in LUAD and LUSC tissue microarray with patients’ information was detected.
Results

We constructed a systematic prognostic landscape in various types of cancer base on the mRNA expression level. We enclosed that higher LPAR6 expression level was associated with better OS in some types of malignancy. Moreover, LPAR6 significantly affects the prognostic potential of various cancers in TCGA, especially in lung cancer. Tissue microarray’s results demonstrated that higher protein level of LPAR6 was correlated with better overall survival of LUAD rather than LUSC cohorts. Further research found that the underlying mechanism of this phenome might be the expression level of LPAR6 was positively associated with infiltrating statuses of devious immunocytes in LUAD rather than in LUSC, that is, LPAR6 expression potentially contributes to the activation and recruiting of CD8 + T, naive T, effector T cell and natural killer cell and inactivates Tregs, decrease T cell exhaustion and regulate T-helper cells in LUAD.
Conclusions

Our discovery implies that LPAR6 is associated with prognostic potential and immune-infiltrating levels in LUAD. These discoveries imply that LPAR6 could be a promising biomarker for indicating prognosis potential and immune infiltration level in LUAD cohorts.
Drug-Handling Problems and Expectations of the Ideal Pediatric Drug — Reported by Children and Their Parents
Authors: Herziger Birthe , Jeschke Sarah , Müller Ruth Melinda , Neininger Martina Patrizia , Bertsche Thilo , Bertsche Astrid 
Published: July 2021

Abstract
Experienced drug-handling problems and inadequately considered expectations for drug therapy have an unfavorable influence on therapy. We performed a questionnaire survey in (i) parents of 0–5-year-old children and (ii) 6–17-year-olds and their parents. We assessed (A) experienced drug-handling problems and (B) expectations for drug therapy. (i) 46 parents and (ii) 103 children and their parents participated in the study. Experienced drug-handling problems were described by (i) 100% of parents and (ii) 62% of children and 70% of parents. Problems concerned the preparation of the drug, dosing, compliance with the time interval, and acceptance. (i) 65% of parents preferred a peroral route of drug administration, while (ii) 74% of children and 86% of parents did so. Preferred characteristics of peroral drug formulations, e.g. liquid versus solid drug formulations or flavor, were highly heterogeneous. Preferences of 6–17-year-old children and their parents matched in 43% to 66%. Conclusion: Most children and their parents had already experienced drug-handling problems. Preferences concerning the ideal pediatric drug were highly heterogeneous and in about half of cases, preferences of children and their parents differed. Thus, the children should be approached directly. If information is solely gained from parents, the children’s needs might remain unmet.
De-implementing Low-Value Care in Cancer Care Delivery: A Systematic Review
Authors: Tabriz Amir Alishahi , Turner Kea , Clary Alecia , Hong Young-Rock , Nguyen Oliver T , Wei Grace , Carlson Rebecca , Birken Sarah A 
Published: July 2021

Abstract
Background

Accumulating evidence suggests that interventions to de-implement low-value services are urgently needed. While medical societies and educational campaigns such as Choosing Wisely have developed several guidelines and recommendations pertaining to low-value care, little is known about interventions that exist to de-implement low-value care in oncology settings. We conducted this review to summarize the literature on interventions to de-implement low-value care in oncology settings, define an agenda for future research, and inform the literature about opportunities for additional work.
Methods

We systematically reviewed the published literature in PubMed, Embase, CINAHL Plus, and Scopus. We screened the retrieved abstracts for eligibility against inclusion criteria and conducted a full-text review of all eligible studies on de-implementation interventions in cancer care delivery. We used the framework analysis approach to summarize included studies' key characteristics including design; outcome(s); type of cancer, objective(s); and de-implementation interventions, determinants of the use ofthe use of de-implementation interventions, and their effectiveness. We assessed included studies’ quality using the NIH Quality Assessment Tools.
Results

Out of 2,793 studies, 13 met our inclusion criteria. Included studies have been published between 2003 and 2020, and the majority (n = 9) of them were conducted in the USA. They covered several cancer types including prostate cancer (n = 4), multiple cancers (n = 3), hematologic cancers (n = 3), lung cancer (n = 1), breast cancer (n = 1), and gastrointestinal cancer (n = 1). Four studies were focused on de-implementing low-value diagnostic tests, six studies focused on de-implementing low-value treatment procedures, and three studies focused on low-value screening services. Most of the de-implementation interventions (n = 11) were effective in reducing low-value care. No study assessed the determinants of the use of de-implementation interventions.
Conclusions

This review showed that to accelerate the reduction of low-value cancer care, instead of solely relying on diffusion new evidence and guidelines (i.e., passive de-implementation), healthcare organizations should initiate de-implementation interventions and implement strategies purposefully aimed at reducing low-value care (i.e., active de-implementation). Additionally, future research should include a broader range of variables such as patients’ perspectives and preferences, unintended effects of de-implementing low-value care, and system-level factors when studying de-implementation.
Analysis of Risk Factors for Perioperative Hidden Blood Loss in Unilateral Biportal Endoscopic Spine Surgery: A Retrospective Multicenter Study
Authors: Wang Haosheng , Wang Kai , Lv Bin , Li Wenle , Fan Tingting , Zhao Jianwu , Kang Mingyang , Dong Rongpeng , Qu Yang 
Published: July 2021

Abstract
Background

Hidden blood loss (HBL) represents an important complication of unilateral biportal endoscopic (UBE) spine surgery. This study aimed to evaluate HBL and it’s possible risk factors among patients undergoing UBE surgery for lumbar degenerative diseases.
Methods

This multicentric retrospective study was conducted in 3 different medical centers between July 2020 and April 2021. Data of patients underwent UBE surgery were extracted by electronic medical record system. The patient’s demographic characteristics and blood loss-related parameters were recorded. We calculated the amount of HBL and explored the association between patient’s characteristics and HBL using Pearson or Spearman correlation analysis. Multivariate linear regression analysis was conducted to identity independent risk factors of HBL.
Results

A total of 136 patients (55 females and 81 males, age range 43 to 74 years) were included in this study. A substantial amount of HBL (469.5 ± 195.3 ml, 57.6 % of TBL, total blood loss) occurred following UBE surgery. Multiple linear regression analysis indicated that the risk factors of HBL were as follows: age (P = 0.000), number of fusion levels (P = 0.015), American Society of Anesthesiologists (ASA) classification (P = 0.046), surgery time (P = 0.017), patient’s blood volume (PBV, P = 0.026), total blood loss (TBL, P = 0.001), postoperative (i.e., day 2 or 3) hematocrit(Hct, P = 0.034), Hct loss (P = 0.005), and fibrinogen (P = 0.028).
Conclusions

A certain amount of HBL occurs in UBE surgery and cannot be ignored in daily clinical practice. The age, number of fusion levels, ASA classification, surgery time, PBV, TBL, postoperative Hct, Hct loss, and fibrinogen are independent risk factors for HBL.
Association of Anxiety With Sperm Quality: a Multicentre Cross-sectional Study in China During the COVID-19 Outbreak
Authors: Wang Yongfeng , He Liting , Yang Yunyi , Tu Lihui , Yang Jigao , Zhang Zhou , Meng Tianqing , Jiang Xianglong , Zhu Wenbing , Li Yushan , Zhang Huiping , Zhao Kai , Zhang Xinzong , Liu Chunyan 
Published: July 2021

Abstract
Objectives: There is no report about association of anxiety on sperm quality during the COVID-19 epidemic. Purpose of this study was to investigate the relationship between anxiety and sperm quality during the COVID-19 outbreak in China.Methods: 896 sperm donors from 7 sperm banks in China were investigated, and passed the screening for sperm donation between 23 January 2020 and 8 June 2020. Semen quality analysis follows the standards of the WHO Fifth Edition Human Semen Examination and Processing Manual. Anxiety symptoms were assessed by the Generalized Anxiety Disorder Scal-7(GAD-7). Logistic regression and linear regression were used to identify the association between anxiety level and sperm quality.Results: Participants with anxiety status (N = 155; 17.3%) had lower sperm concentration (56.81 ± 32.70 vs. 47.21 ± 30.76 [106/mL]), sperm volume (3.58 ± 1.65 vs. 3.04 ± 1.69 [mL], P < 0.001), total sperm count (7.29 ± 1.23 vs. 6.56 ± 1.63 [106], P < 0.001), and progressive motility (50.86 ± 12.45 vs. 38.50 ± 17.00 [%], P < 0.001) than those without anxiety. Linear regression showed that anxiety symptoms was significantly associated with 8.13 (95% confidence interval [CI]: 2.51, 13.75), 0.49 (0.20, 0.79) ,51.05 (23.43, 78.68) and 12.15 (95% CI: 23.43, 78.68), reduction in sperm concentration, semen volume, and total sperm count and progressive motility respectively.Conclusions: This study revealed that anxiety symptoms were negatively associated with semen quality, and interaction was discovered between debt stress and anxiety.
Desert Locust Schistocerca gregaria in Rajasthan, India and Establishing an Early Warning System for Locust Control in India
Authors: Jhiknaria Hameer 
Published: July 2021

Abstract
Desert Locust is considered to be the most serious pests that cause a devastated damage to the crops and the other agricultural products during their invasions. The Desert Locust is a major threat for food security, livelihoods, environment and economic development in a region. The recent Locust Outbreak caused major damage to standing crops and vegetables in the Central and Western states of India, including Rajasthan, Punjab, Haryana, and Madhya Pradesh, with Rajasthan being the most affected. India had experienced such massive locust invasion after two decades. Establishing an Early Warning System for Locust Control in India is essential to reduce the impact by providing timely and relevant information in a systematic way contributing to increasing in resilience of the country. The distribution of Desert Locusts in Rajasthan, India has been presented from June 2019 to August 2020, along with the key Environmental Factors of Temperature, Rainfall, Soil Moisture and Prevalence of Vegetation significantly affecting Locust Activity. All the datasets used were obtained from Secondary sources. These datasets were obtained from Open Government Data (OGD) Platform. The Maps created in the study show the Distribution of Desert Locusts in Rajasthan, India; along with this the Choropleth map show Average- Temperature, Rainfall, Soil Moisture and Normalized Difference Vegetation Index (NDVI), all at District level. The Early Warning System for Desert Locust Control in India is a key integration of four key elements of: Risk Knowledge, Monitoring and Warning Service, Dissemination and Communication and Response Capability, and four-four sub elements of each key element. Establishing an Early Warning System for Locust Control in India is of paramount importance.
Effects of Early Estradiol Valerate Administration On Bone Turnover Markers in Surgically Induced Menopausal Women
Authors: Vatrasresth Jarika , Suwan Ammarin , Panyakhamlerd Krasean 
Published: July 2021

Abstract
Background

Compared with natural process, surgically induced menopausal women have a higher bone loss rate. The objectives of this study were to evaluate effects of early treatment with estradiol valerate on the bone turnover markers levels after surgically induced menopause.
Methods

This prospective study enrolled 48 pre and perimenopausal women who underwent hysterectomy with oophorectomy for benign gynecologic conditions. Two weeks after surgery, all participants were assessed for menopausal hormone therapy (MHT) indications. Estrogen therapy was prescribed for those who had indication and accepted treatment (hormone treatment group). The others who had no MHT indication were allocated to no treatment group. Serum CTX and P1NP levels were measured at preoperative and 12 weeks postoperative.
Results

The median serum CTX and P1NP at 12 weeks were significantly different between two groups (p-value < 0.001 and 0.004, respectively). Median serum CTX and P1NP levels of women in the hormone treatment group were 55% and 40% lower than the women in no treatment group, respectively. At 12 weeks after surgery, serum CTX and P1NP levels were significantly elevated among women who did not receive hormone treatment (p-value < 0.001 and 0.002). In contrast, there were no significant change in the hormone treatment group.
Conclusion

Surgically induced menopausal women who received early estradiol valerate therapy had significantly lower levels of serum CTX and serum P1NP compared to women who did not receive treatment at 12 weeks after surgeries. This indicated that early estradiol valerate treatment could significantly suppress high bone-remodeling process in women with acute estrogen deprivation conditions.
Trial registration:

Thai Clinical Trial Registry identification number TCTR20190808004, retrospective registered since 2019-08-08. http://www.thaiclinicaltrials.org/show/TCTR20190808004</url>
Scarless genome editing reveals risk SNP rs6983267-G and lncRNA CCAT2 dictate targetable PI3K signaling dependence in WNT-dysregulated CRC
Authors: Coggins Nicole B. , O’Geen Henriette , Lott Paul C. , Segal David J. , Carmona Luis Carvajal 
Published: July 2021

Abstract
Genome-wide association studies have identified numerous loci associated with increased risk for colorectal cancer (CRC), including 8q24.21 which contains a known enhancer of proto-oncogene MYC . However, the role of candidate functional SNP rs6983267 within this locus remains unclear. Here, we generate isogenic cellular models of risk SNP rs6983267 in human CRC line, HCT-116. Comprehensive molecular characterization reveals risk allele-G drives enhancer DNA contacts with downstream regions that include MYC . Absence of risk allele leads to activation of lncRNA CCAT2 . Rather than changes in MYC expression, we observe activation of alternative growth factor signaling pathways with loss of both risk allele and CCAT2 expression. Analysis of TCGA CRC cases demonstrates low CCAT2 expression combined with non-risk rs6983267 genotype correlate with higher frequency of PI3K mutations in CRC patients displaying WNT dysregulation. Together, these provide a potential biomarker for therapeutically targetable PI3K dysregulation in CRC and application in cancer precision medicine.
Restless Rainbows And Bold Browns: Personality of Domesticated Trout Predicts Invasiveness And Impact
Authors: McGlade Ciara L. O. , Dickey James W. E. , Kennedy Richard , Donnelly Shannon , Nelson Clare-Ann , Dick Jaimie T. A. , Arnott Gareth 
Published: July 2021

Abstract
Personality and behavioural syndromes are increasingly recognised in many animal species and are now seen as critical to the prediction of non-native species success and impacts. Rainbow trout and brown trout have been introduced globally, but differ in patterns of establishment success and ecological impact. While environmental tolerance may be a driver, thus far the role of behaviour has not been rigorously tested. Here, we investigated whether diploid rainbow trout and diploid and triploid brown trout differ among several key behavioural measures linked to invasibility. We assessed activity, boldness, aggression, and feeding, using open field, novel object, shelter, mirror, feeding, and functional response experiments. We also tested within each fish type for behavioural syndromes comprising correlations among activity, boldness and aggression. Rainbow trout were more active and aggressive but less bold than diploid and triploid brown trout. In small groups, however, rainbow trout were bolder than both types of brown trout. Diploid brown trout were more active and bolder than triploids when tested individually. There was no association between activity and boldness in rainbow trout, but there was in both brown trout. The increased activity and aggression of rainbow trout may reflect an increased stress response to novel situations, with this response reduced in a group. These results suggest that rainbow trout do not manage their energy budgets effectively, and may explain why they are implicated in fewer ecological impacts. Comparative analyses of multiple behaviours of invasive species and genetic variants may thus be key to understanding and predicting invader success and ecological impacts.
Curved Interference Patterns---Novel Double Slit and Cross-double Slit Experiments (2)
Authors: Peng Hui 
Published: July 2021

Abstract
Young’s double slit experiments represent the mystery of quantum mechanics. To explore the mystery, varieties of the double slit and cross-double slit experiments were performed. In this article, we show novel phenomena that the interference patterns of the double slit/cross-double slit experiments can be curved. The curvatures depend on the orientation of the diaphragms of the double slit/cross-double slit. Those experiments provide comprehensive data for developing/testing a theoretical model.
Anais II Simpósio Científico da Área da Saúde da Universidade Brasil
Authors: Simonato Luciana Estevam , Melo Elizabete Santos , Mininel Francisco José , Jesus Giselle Juliana de , Lopes Leandro Teixeira Paranhos , Silva Milena Milena Carla Queiroz da , Boer Nagib Pezati , Franqueiro Nicezia Vilela Junqueira , Silva Wagner Rafael da 
Published: July 2021

Editorial
Caro(a) Leitor(a),
A Universidade Brasil - Campus Fernandópolis vivenciou nos dias 7 e 8 de dezembro de 2020 o II Simpósio Científico da Área da Saúde, que foi idealizado com o intuito de os alunos dos diversos cursos da área da saúde do Campus Fernandópolis pudessem participar apresentando trabalhos científicos, tais como: Biomedicina, Educação Física, Enfermagem, Farmácia, Fisioterapia, Medicina, Medicina Veterinária, Nutrição e Odontologia. Nesta segunda edição, foram inscritos 139 trabalhos nas áreas de Biomedicina, Enfermagem, Farmácia e Odontologia, distribuídos nas modalidades Pesquisa Científica, Caso Clínico e Revisão de Literatura.
Convido todos vocês para que desfrutem deste momento, esperando que aproveitem ao máximo os ensinamentos que serão transmitidos. Importante lembrar que neste mundo globalizado e competitivo não há como crescer profissionalmente sem agregar novos conhecimentos. Todos os dias!!!
Obrigada, sejam bem-vindos,
Profa. Drª. Luciana Estevam Simonato
Presidente - II Simpósio Científico da Área da Saúde da Universidade Brasil - Campus Fernandópolis/2020
Pink Pigmented Facultative Methylotrophic Bacteria Isolated from Fermented Philippine Shrimp Paste
Authors: Christian Jordan O. dela Rosa  , Anthony C. Lee  , Windell L. Rivera  
Published: July 2021

Pink pigmented facultative methylotrophic (PPFM) bacteria are ecologically distributed microorganisms. They have been isolated in many types of ecosystems like soil, water, air, in association with plants and even as pathogens in humans. However, a yet unexplored area for PPFM bacteria research is in food. Hence, the objective of this study was to establish the presence of PPFM bacteria in Philippine fermented food, in particular shrimp paste, and characterise them phenotypically and genotypically. A total of 13 PPFM bacteria were obtained from Philippine shrimp paste. Sequencing of the 16S rRNA gene revealed that the PPFM bacterial isolates belong to the genus Methylobacterium. A total of 35 phenotypic characterisations were performed that included morphological, biochemical and physiological tests. Phylogenetic tree was constructed to establish the genetic relatedness of the isolates. Morphological test results showed that all 13 isolates were consistent with the established phenotypic characters of the genus such as pink colony colour, Gram negative and rod-shaped. Biochemically, the use of API® 20 NE tests showed heterogeneity of results and physiological tests exhibited that the isolates are primarily mesophilic and halotolerant, being able to grow at 2% salt. Phylogenetic analysis showed that the isolates are Methylobacterium populi, M. dankookense, M. lusitanum, M. radiotolerans and M. zatmanii. This study confirmed the presence and diversity of PPFM bacteria in Philippine shrimp paste. Further studies are needed to show the functional activity of Methylobacterium in Philippine shrimp paste production.
New Mineral Names,
Authors: Belakovskiy Dmitriy I. , Uvarova Yulia 
Published: July 2021

Abstract

In this issue
This New Mineral Names has entries for 10 new species, including huenite, laverovite, pandoraite-Ba, pandoraite-Ca, and six new species of pyrochlore supergroup: cesiokenomicrolite, hydrokenopyrochlore, hydroxyplumbopyrochlore, kenoplumbomicrolite, oxybismutomicrolite, and oxycalciomicrolite.
Análisis sistemático sobre el uso de la Realidad aumentada en Educación Infantil.
Authors: Rivas Rebaque Begoña , Gértrudix Barrio Felipe , Gértrudix-Barrio Manuel 
Published: July 2021

El informe Horizon 2019 situaba el aprendizaje móvil como una tecnología a ser adoptada en Educación Superior a corto plazo y tenía en cuenta la realidad aumentada (RA) como tendencia a medio plazo. Si estas tecnologías avanzadas están presentes en cualquier ámbito de nuestra vida diaria sin distinción de edades, límites o escenarios ¿Por qué no extender también su práctica en el entorno educativo de edades tempranas? Así, este estudio sobre RA tiene como finalidad 1) revisar si esta evolución ha sido positiva; 2) indagar sobre las metodologías y estrategias en el uso de la RA en la etapa de Educación Infantil; y 3) explorar si existen limitaciones a la hora de utilizar este tipo de tecnología en edades tempranas como recurso didáctico. El método ha sido la revisión sistemática de 49 documentos (entre artículos y papers) publicados de enero de 2011 a abril de 2021, en la base de WOS (SSCI), siguiendo los criterios de PRISMA. Los hallazgos extraídos sintetizan las tipologías de análisis de datos que se llevan a cabo, los diferentes usos que se efectúan con realidad aumentada y las diferentes conclusiones que se extraen de esas experiencias.