bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pedagogical challenges in Distance Learning during COVID-19 conditions – Experience of Latvia
Authors: Jurs Pāvels , Kulberga Inta 
Published: November 2021

Due to the global pandemic caused by the spread of coronavirus disease, the educational process has experienced very significant transformations – in the pedagogical process both pupils and parents, teachers and education policy makers have encountered essential challenges and an unprecedent experience The aim of the research, based on the theoretical study of the distance learning concept and empirical research, and finding out the teachers’ attitude towards distance learning, is to describe the Latvia experience in distance learning during COVID-19 conditions. The research's methodology is based on teacher survey, regulatory analysis, and concessional analysis. The study highlights problems in the context of distance learning and makes a significant contribution to further research. Analysing the results of the empirical study and outcomes of the survey, it has been concluded that teachers feel psycho-emotional and physiological overload due to distance education.

Keywords: distance learning; education; pedagogical process; pupil; teacher
State regulation and development of digital educational platforms
Authors: Salakhova Valentina B. , Erofeeva Maria A. , Pronina Elena V. , Belyakova Natalia V. , Zaitseva Natalia , Ishmuradova Izida I. 
Published: November 2021

The introduction of digital platforms influences all areas of social development, including the education sector. The Russian government, in a bid to take advantage of this, has encouraged the development of a solid educational system that can support digitalization’s effect on the economy. The paper aims to analyze the development of Russian digital platforms in general and educational platforms, as a decisive factor in economic competitiveness on the world market. The study was a descriptive research and Russia was the main population for the study. The research made use of secondary data from national and international sources. An analysis of modern practices in the field of digital educational platforms shows that educational organizations cannot independently use digital technologies at the new level of requirements. For this purpose, a functioning digital ecosystem is needed that would be able to provide a variety of new technologies in education.

Keywords: state development, digital educational platforms, digital learning, digital educational environment.
THERMAL CONTROL OF MECHANOCHEMICAL REACTION
Authors: Tolchinsky Yu. , Ved V. , Rofe-Beketova I. 
Published: November 2021

Mechanochemistry studies and explains the processes of chemical and physicochemical transformations that are generated by mechanical action on a substance. When carrying out deep mechanochemical transformations, as a rule, it is necessary to transfer to solid reagents a portion of energy comparable to the energy of interatomic bonds. For this, various machines and apparatus are used, such as extruders, in which mechanical energy is constantly transferred to the crushed material.
The article discusses the interaction of two reagents in a simple chemical reaction in the state of a mixture of particles of two types, which occurs during compression of particles having a rough irregular shape, and colliding with each other, forming areas of contact. Significant stress concentrations and heating of the substance with the formation of a new phase arise in these regions.
Thermal control of the mechanochemical reaction is to maintain an optimal balance of dissipative heat and heat from the coolant in the worm reactor so that the rate of flow and the final product of the reaction meet the specified specifications. The formulas provided in the article for calculating the coefficient of the rate of mechanochemical reaction, heat transfer between worm reactor and jacket channel, heat exchange between jacket and environment allows to calculate the balance conditions for thermal management.
The block diagram of the technological line, which is presented in the article, is more economical in comparison with carrying out the same reaction in a solvent. The economic benefit lies in the elimination of the steps of introducing and removing the solvent from the reaction product.
At the end, it is indicated that the mechanochemical reaction of the transformation of a mixture of two dispersed materials consisting of solid particles into a liquid can be realized in continuous conditions in a flow mode in a worm machine. And thermal control of the course of a mechanochemical reaction can be carried out using controlled heat exchange with a coolant in a jacket under conditions of turn-around spatial dispersion.
Microbiome Profiling of Enterotoxigenic Escherichia Coli (ETEC) Carriers Highlights Signature Differences Between Symptomatic and Asymptomatic Individuals
Authors: Higginson Ellen Elizabeth , Sayeed Md Abu , Dias Joana Pereira , Shetty Vignesh , Ballal Mamatha , Srivast Sunil Kumar , Qadri Firdausi , Dougan Gordon , Mutreja Ankur 
Published: November 2021

Abstract
BackgroundEscherichia coli (ETEC) are one of the top causes of diarrhoea in children in low- and middle-income countries (LMICs). However, large-scale pathogen burden studies in children have identified ETEC in the guts of symptomatic patients and controls. The factors that influence this balance between carriage and disease are poorly understood, but it is postulated that the gut microbiome may play a role in either resistance or progression to disease. In this study, we investigated the microbiome profiles, using shotgun DNA sequencing, of children and adults from Bangladesh who were asymptomatically or symptomatically infected with ETEC. ResultsSymptomatic patients had significantly higher numbers of sequenced reads mapping to both E. coli and the two ETEC toxins (LT and ST), suggesting higher bacterial burden. They were also significantly more likely to be co-infected with enteroaggregative E. coli (EAEC) and had higher proportions of other Gammaproteobacteria, including Klebsiella, Salmonella, and Haemophilus. Colonisation with ETEC (symptomatic or asymptomatic) was also associated with increased prevalence of antimicrobial resistance (AMR) genes, most notably those of the b-lactamase class. Taxonomic profiles were distinctly different between all groups in both species richness (alpha diversity) and composition (beta diversity), although the direction of these changes was different in adults and children. As seen in previous studies, children with high E. coli burdens also had higher proportions of Streptococcus spp., while healthy children were more heavily colonised by several Bifidobacterium spp. ConclusionsOur study provides insight into the microbiome changes that occur upon infection with ETEC in an endemic setting, and provides rationale for future studies investigating how the microbiome may protect or predispose individuals to symptomatic infections with gastrointestinal pathogens.
Paternal breastfeeding self-efficacy and maternal breastfeeding patterns at three months postpartum.
Authors: kiaei zahra , Zahrani Shahnaz Tork , Janati Padideh , Nasiri Malihe 
Published: November 2021

Abstract
Introduction: Evidence suggests that breastfeeding has beneficial effects on both mother and baby. Fathers' attitudes and self-efficacy are effective factors in breastfeeding. Paternal breastfeeding self-efficacy means the ability of fathers to help their spouses to breastfeed their infants, which seems to affect breastfeeding. The aim of this study was to evaluate the self-efficacy of fathers and its relationship with infant feeding patterns at three months.Methods: This descriptive correlational study was conducted in 2019 on 206 fathers during the discharge of their wife after childbirth. The inclusion criteria were having a singleton infant, birth weight of 2500-4000 g, Apgar score of 8-10, willingness to participate in the study, the parents living together, and not taking any drugs affecting breastfeeding. A demographic information questionnaire and the paternal breastfeeding self-efficacy scale were completed by the fathers; the maternal breastfeeding pattern questionnaire was also completed three months after delivery. Data were analyzed in SPSS-23 statistical software using the independent t-test, Spearman’s test, Pearson’s coefficient, the ANOVA, and the Chi-square test.Findings: The paternal breastfeeding self-efficacy score was 58.33 in this study. The paternal breastfeeding self-efficacy score of the fathers attending antenatal classes was higher than the others (P-value=0.003). There was a significant relationship between paternal cooperation in prenatal care and paternal breastfeeding self-efficacy score (P-value=0.001). There was no correlation between paternal breastfeeding self-efficacy scores and maternal breastfeeding patterns three months after delivery (P-value=0.99).Conclusion: According to the results, there was no relationship between paternal breastfeeding self-efficacy scores and maternal breastfeeding patterns three months after delivery. However, significant relationships were found between paternal breastfeeding self-efficacy score at discharge and the fathers’ cooperation in prenatal care and attendance of antenatal classes.
DOPO-Modified Cellulose Microsphere: Preparation and Application for Selective Adsorption U(VI) under Acidic Solutions
Authors: Wen Di , Xie Cong , Zhang Manman , Dong Zhen , Zhai Maolin , Zhao Long 
Published: November 2021

Abstract
Effective radioactive wastewater disposal is of great significance to the wide use of nuclear energy. In this work, 4, 4ˊ-[1, 4-phenyl-bis (9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-yl) dimethyneimino)] diphenol (t-DOPO) was used to modify microcrystalline cellulose microsphere (t-DOPOR) to further enhance it affinity toward U(VI) through radiation method. The t-DOPOR were characterized for structural, morphological, and thermal properties by FTIR, SEM and TGA, which prove that t-DOPO is successfully modified on cellulose. Combination the advantage of cellulose and t-DOPO, t-DOPOR possessed abundant functional group (-OH, -NH and P=O), and exhibited extremely strong affinity toward U(VI) with a maximum adsorption capacity of 51.51 mg/g at pH 3. Particularly, A large distribution, KdU, up to 2.54×104 mL g−1 is found, implying extremely strong affinity toward U(VI) than Ln(III) (La(III), Eu(III), Dy(III), Yb(III)) at the binary system. Dynamic column experiment confirmed that t-DOPOR could separate selectively U(VI) in column experiment. In addition, even in the simulated groundwater trace amount of U(VI) was also eliminated efficiently by t-DOPOR. Lastly, the adsorption mechanism elaborated by XPS analysis was inner-sphere surface complexation between U(VI) and -OH, -NH and P=O groups of t-DOPOR. Overall, the synthesized t-DOPOR may be utilized as a promising adsorbent for separation and remediation of U(VI) from wastewater.
Genomic Heterogeneity Contributed To The Different Survival Between Adult and Pediatric Acute Lymphoblastic Leukemia
Authors: Chen Yanxin , Zheng Yongzhi , Hong Yunda , Wen Jingjing , Li Jiazheng , Huang Yan , Chen Yi , Hu Jianda 
Published: November 2021

Abstract
Prognosis of acute lymphoblastic leukemia (ALL) in adults is inferior to children. Hence, ALL is still a challenging disease to be cured in adult population. Aberrant genetic alterations have been observed previously in ALL, while the patterns of differential gene alteration have not much been comprehensively determined in the adult and pediatric ALL on a genome-wide scale. This study was attempted to investigate the biological differences in genomic profiling between the adults and children with ALL, and the relationship between the genomic heterogeneity and prognosis. The results showed the similar common mutation types in two populations but the increased prevalence of genetic alterations in adult ALL. The median number of detected gene mutations was 17 (range: 1–53) per sample in adult ALL and 4.5 (range: 1–19) in pediatric ALL(P<0.001). A significant correlation between the increased number of gene mutations and age was found (R2 = 0.5853, P<0.001). 122 and 53 driver genes were identified in adult and pediatric ALL samples, respectively. The IKZF1, IDH1 and TTN mutations were significantly enriched in adult ALL. The incidence of relapse was 40.0% and 9.6% in the adult and pediatric ALL, respectively(P=0.0003). The overall survival (OS) and relapse free survival (RFS) of adult ALL were poorer than pediatric ALL (P=0.0002, P<0.001, respectively). This genomic landscape enhanced the understanding of the biological differences of ALL between the two populations and provided a clue for novel therapeutic approaches.
The Ankle Energetic Effect of Functional Insoles on Walking
Authors: Nagai Maki , Tazawa Masayuki , Kanaya Takahumi , Arii Hironori , Ibe Yoko , Nakao Yumiko , Wada Naoki 
Published: November 2021

Abstract
Background：Although insoles made of various materials and shapes have been developed to improve performance in sport activities, few objective evaluations on their effectiveness have been conducted. We investigated the effect of insoles supporting the cuboid bone and anterior part of the calcaneus in healthy individuals.Methods:The subjects included 18 healthy males and females. They walked in standardized shoes with a flat insole (a flat insole made of polyurethane without an arched shape on the surface) and a functional insole (made of carbon and supporting the cuboid and anterior part of the calcaneus). We used a three-dimensional motion analysis device and a force plate to analyze gait and quantitatively compared the effect of functional insoles.Results:There was no difference in the parameters of gait analysis (walking speed, cadence, step length, stride length) between flat insoles and functional insoles. The functional insoles reduced ankle power without reducing walking ability. A comparison between Group A (n = 7), in which the left-right difference in ankle power was more than 20%, and Group B (n = 11), in which the left-right difference in ankle power was less than 20%, indicated that the use of functional insoles reduces the left-right difference of ankle power in the group with a larger difference in power.Conclusion：We believe that the use of functional insoles reduced ankle power without reducing walking ability and equalized left-right power. It may therefore reduce the burden on the muscles of the unilateral lower limbs and improve sport performance.Trial registration：The medical research ethics review committee for individuals at Gunma University (study number HS2017-229)　Registered 20 febluary 2018, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000034362
Healthcare Professionals’ Perceptions of Support for Family Members in Specialist Palliative Care Inpatient Units – a Qualitative Descriptive Study
Authors: Soikkeli-Jalonen Anu , Mishina Kaisa , Virtanen Heli , Charalambous Andreas , Haavisto Elina 
Published: November 2021

Abstract
Purpose: The aim of this study was to describe healthcare professionals’ (HCPs) perceptions of the support for family members (FMs) of palliative care cancer patients in specialist palliative inpatient units. Methods: A qualitative descriptive design was applied. The data were collected with focus group interviews and analysed with inductive content analysis.Results: Information sharing was recognised as an essential element of support. Also, emotional support, discussions and additional support were offered. Practices to improve support of FMs included a possibility to allocate recourses to the families, systematic support and strengthening HCPs’ competence in family care. Conclusions: The opportunities to implement support focusing directly on FMs were described as restricted. Organisational resources were limited in inpatient units. HCPs felt that they did not have enough time to spend with FMs, and the facilities were also not always suitable to support FMs’ presence and participation. Therefore, there is a need for systematic support and interventions for FMs that could be implemented in inpatient units by the HCPs as a part of the daily care. Furthermore, additional training for the HCPs in palliative family care is needed.
Adaptation of Brunel Lifestyle Physical Activity Questionnaire into Turkish; The Validity and Reliability Study
Authors: Erkılıç Büşra Aydın , Yazıcı Canan Günay , Armağan Mehmet , Ötegen Ömer , Sarı Zübeyir 
Published: November 2021

Abstract
Background: This study aims to investigate the reliability and validity of the Turkish version of the Brunel Lifestyle Physical Activity Questionnaire (BLPAQ) and examine the cultural adaptation of the questionnaire.Methods: After the translation process, the test-retest reliability of the Turkish version of the questionnaire was analyzed with 24 (31.20±5.0 years old; 50% female) participants (2nd test was done 15 days after the first test). In addition, the validity of the scale was evaluated by the correlation between the BLPAQ and the International Physical Activity Questionnaire Short Form (IPAQ-SF) completed by 113 (30.59±5.40 years old; 63.7% Female) participants.Results: A powerful positive and significant correlation was found between the correlation coefficients of the BLPAQ's PPA and UPA subscales between both tests (respectively r=0.96, p<0.01; r=0.87, p<0.01). The Cronbach's alpha coefficient was found to be 0.77 (quite reliable). The PPA subscale of the BLPAQ was positive with the IPAQ-SF's high-intensity physical activity subscale (r=0.47 p=0.00) and total IPAQ-SF excluding sitting (r=0.50 p=0.00) medium in the direction and low positive correlation with the walking activity subscale (r=0.25 p=0.024). No significant correlation was found between the UPA subdivision of BLPAQ and IPAQ-SF (p>0.05).Conclusion: BLPAQ, adapted into Turkish, is a valid and reliable tool that can be used to determine lifestyle according to physical activity level.
Nilai Pendidikan Karakter Peduli Sosial dan Menghargai Prestasi pada Teks Narasi Buku Siswa Bahasa Indonesia VII
Authors: Purwanti Nunik , Zulfa Lilis Anifiah 
Published: November 2021

Moral decline in the nation's next generation is now increasingly worrying. This can be seen from the increasing number of juvenile delinquency that occurs. Examples are cases of drug abuse, free sex, bullying, and various criminal acts committed by minors. To prevent this from getting worse, it is necessary to take decisive action and inculcate character values ​​that must be carried out by various parties, one of which is the teacher. Literature is one of the media that can be used to instill character values ​​in students. This study will analyze the character values ​​contained in the narrative text in the Indonesian Student Book Revised 2017 Edition for class VII. This study used descriptive qualitative method. The source of the data in this study came from the narrative text in the Indonesian Language Student Book Revised 2017 Edition for Class VII. Data collection with documentation technique by reading and taking notes. Data analysis techniques include data reduction, data presentation, and drawing conclusions. The results showed that there were six forms of social care character values ​​with indicators a) the ability to be willing to give help to others, b) the students' awareness to be willing to sacrifice, and c) the ability to share the suffering of others. There are five forms of character value appreciating achievement with indicators a) appreciating the achievements of others, b) studying diligently for high achievement, and c) being grateful for the achievements achieved by contributing to the benefit of the nation, state, and religion.
Eﬃcacy and safety of short course chemotherapy regimens in older children and adolescents with multiple and extensive drug resistant respiratory tuberculosis
Authors: Panova L. V. , Ovsyankina E. S. , Krushinskaya E. A. , Khiteva A. Yu. , Piskunova O. A. 
Published: November 2021

The objective of the study: to evaluate the eﬃcacy and safety of short course chemotherapy regimens for multiple/extensive drug resistant tuberculosis of the respiratory system (MDR/XDR) in older children and adolescents.Subjects and Methods. A cohort prospective controlled study (2017 to 2019) included 23 patients from 13 to 17 years old with various clinical forms of respiratory tuberculosis with multiple/extensive drug resistance.Results. In 22 out of 23 cases, the following chemotherapy regimen was used: 6 months - the intensive phase / 6 months - the continuation phase, in one patient – 3 months of the intensive phase / 9 months of the continuation phase. In 15 out of 23 cases, the chemotherapy regimens in the intensive phase, taking into account the MBT drug sensitivity test, consisted of 5 drugs, in 8 cases – of 4 drugs. During the continuation phase, all patients received 3 drugs. Of the 23 patients, 8 patients used bedaquiline in short course chemotherapy regimens: 2 – 1 course, 6 – 2 courses.Conclusion. The possibility of reducing the main course of chemotherapy for MDR/XDR TB in children and adolescents to 12 months instead of 18-24 months has been proved.
Possibilities of speciﬁc immunological tests in patients with TB/HIV coinfection
Authors: Motanova L. N. , Grabovskaya M. S. , Folts I. V. 
Published: November 2021

The objective of the study: to study the possibilities of skin tests with tuberculosis recombinant allergen (TRA) in the diagnosis of tuberculosis in HIV-positive patients in the region with a high prevalence of tuberculosis.Subjects and Methods. Medical ﬁles of 85 patients were retrospectively analyzed, all the patients suﬀered from TB/HIV coinfection and underwent the skin test with TRA.Results. The skin test with TRA was found to be signiﬁcantly valuable for the diagnosis of tuberculosis in patients with TB/HIV coinfection. The correlation between the intensity of response to the TRA test and CD4+ count was detected (p = 0.011). The lowest values were observed for CD4+ counts below 100 cells/μL. The direct correlation between the intensity of response to TRA and the stage of HIV infection was proved. No eﬀect of the form of tuberculosis, the phase of the tuberculosis disease, or drug sensitivity on the intensity of response to TRA was found. Among tuberculosis patients with bacterial excretion (n = 48), 68.8% of patients responded positively to the TRA test, and in those with no bacterial excretion, the positive reaction was observed in 81.1%.
The new attenuated strain of <i>Mycobacterium tuberculosis</i> BN. Characteristics and vaccine properties
Authors: Nikonenko B. V. , Аzhikina T. L. , Grigorov A. S. , Linge I. A. , Logunova N. N. , Kayukova S. I. 
Published: November 2021

The objective of the study: to obtain a live attenuated strain and investigate its properties by multiple cultures of the virulent strain of Mycobacterium tuberculosis H37Rv.Subjects and Methods. The original virulent strain H37Rv was subcultured 70 times in 7H9 liquid medium. Genetic properties of the new strain, degree of avirulence, and vaccine properties were studied.Results. Mycobacteria of the new strain MtbBN lost their virulence to inbred mice. Eight mutations were identiﬁed by whole genome sequencing: single nucleotide insertions and deletions (in/del) distinguishing the MtbBN and H37Rv strains. The MtbBN strain demonstrated vaccine potential at the BCG level. Additionally, in some genetic models, the attenuated strain was highly eﬀective in protecting inbred mice when infected with Mtb H37Rv as opposed to BCG.