bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-time Factory Smoke Detection Based on Two-stage Relation-guided Algorithm
Authors: Wang Zhenyu , Ji Senrong , Yin Duokun 
Published: July 2021

Abstract
Recently, using image sensing devices to analyze air quality has attracted much attention of researchers. To keep real-time factory smoke under universal social supervision, this paper proposes a mobile-platform-running efficient smoke detection algorithm based on image analysis techniques. Since most smoke images in real scenes have challenging variances, it’s difficult for existing object detection methods. To this end, we introduce the two-stage smoke detection (TSSD) algorithm based on the lightweight framework, in which the prior knowledge and contextual information are modeled into the relation-guided module to reduce the smoke search space, which can therefore significantly improve the shortcomings of the single-stage method. Experimental results show that the TSSD algorithm can robustly improve the detection accuracy of the single-stage method and has good compatibility for different image resolution inputs. Compared with various state-of-the-art detection methods, the accuracy AP mean of the TSSD model reaches 59.24%, even surpassing the current detection model Faster R-CNN. In addition, the detection speed of our proposed model can reach 50 ms (20 FPS), which meets the real-time requirements, and can be deployed in the mobile terminal carrier. This model can be widely used in some scenes with smoke detection requirements, providing great potential for practical environmental applications.
Anaemia Prevalence, Severity and Associated Risk Factors Among Indigenous Temiar Orang Asli Community in Kelantan, Peninsular Malaysia
Authors: Rahim Mohd Amirul Fitri A. , Munajat Mohd Bakhtiar , Wahid Wathiqah , Dian Nor Diyana , Rakna Mohd Ikhwan Mukmin Seri , Ghazali Nuraffini , Hassan Noor Wanie , Divis Paul C. S. , Lubis Inke Nadia D. , Chuangchaiya Sriwipa , Kasri Mohd Rafiq Mohd , Id Zulkarnain Md 
Published: July 2021

Abstract
Anaemia continues to be a major public health challenge in developing countries. An important and often unreported group at risk for anaemia is indigenous communities. This study aimed to assess the prevalence of anaemia and to identify its determinants in the indigenous Temiar Orang Asli community in Peninsular Malaysia. A community-based cross-sectional study was conducted in 2019. Six hundred and forty participants aged one and older were enrolled and personal characteristic data were collected. Anaemia status was determined using haemoglobin level (Hb) according to the World Health Organization (WHO) Hb cut-off. The overall anaemia prevalence was 44.7% (286/640) and the prevalence rates of mild, moderate and severe anaemia were 42.7%, 50.7% and 6.6%, respectively. Anaemia-specific prevalence varied significantly by age groups (P<0.001) and was highest in the 6–17 group for mild anaemia (39.3%, 95% CI: 30.6–48.6), followed by ≤5 group for both moderate anaemia (43.4%; 95%CI: 35.2–51.9) and severe anaemia (42.1%; 95%CI: 20.3–66.5). In the multivariate logistic regression, anaemia was associated in age groups of ≤5 (adjusted odds ratio [aOR] 5.6 [95%CI: 3.3–9.4], P<0.001) and 6–17 (aOR 2.1 [95%CI: 1.4–3.2], P<0.001) as well in those living in Lambok (aOR 2.7 [95%CI: 1.3–5.5], P = 0.006). This study has highlighted the high prevalence of anaemia among indigenous Orang Asli in Peninsular Malaysia and revealed that younger children were positively associated with childhood anaemia. Effective interventions and special attention for this indigenous population need to be implemented to reduce the risk of anaemia.
Protective Effect of Dachengqi Decoction on Pancreatic Microcirculatory in Severe Acute Pancreatitis via Down-regulating HMGB-TLR-4-IL-23-IL-17A Mediated Neutrophil Activation Though Targeting SIRT1
Authors: Wang Jia , Peng Lei , Chang Dan , Hong Da-qing , Zhang Jiong 
Published: July 2021

Abstract
BackgroundDachengqi decoction (DCQD), one of classic prescription of Chinese herbal medicine has been widely used in clinic to treat severe acute pancreatitis (SAP). The damage of pancreatic microcirculation plays key pathogenesis of SAP. However, little is known about the molecular pharmacological activity of DCQD on pancreatic microcirculation in SAP. Therefore, the purpose of the study attempted to confirm the improvement of DCQD on pancreatic microcirculation is associated with suppressing neutrophil mediated immune-inflammatory response through promoting the inactivation of HMGB1-TLR-4-IL-23-IL-17A axis via targeting the SIRT1 signal pathway in SAP.Material and MethodsSodium taurodeoxycholate and cerulein were used to establish model of SAP in vitro and vivo, respectively. The pancreatic pathological morphology, wet weight ratio, myeloperoxidase (MPO) activity, cell viability and microcirculatory function of the pancreas, as well as serum lipase and amylase expressions were evaluated. The expression levels of SIRT1, acety-HMGB1, TLR-4, HMGB1, IL-23, IL-17A, neutrophil chemokines (KC, LIX, and MIP-2), and inflammation-related factors (IL-6, IL-1β, and TNF-α), the translocation of HMGB1 and the interaction of SIRT-HMGB1 in the pancreas and serum were determined by ELISA real-time PCR, western blotting and immunoprecipitation.ResultsIn-vivo studies showed DCQD or neutralizing antibody (anti-23p19 or anti-IL-17A) could significantly decrease the activity of lipase, amylase, down-regulate the expression of CD68, MPO, wet/weight, IL-1β, IL-6, TNF-α,neutrophil chemokines (KC, LIX, MIP-2 ), alleviate pathological injury, and improve the microcirculatory function of the pancreas in rats with SAP. Moreover, DCQD remarkably augmented SIRT1 expression, promoted SIRT1 and HMGB1 combination, reduced HMGB1 translocation from nuclear to cytoplasm, and alleviated the expression of acetyl-HMGB1, HMGB1, IL-17A, TLR-4 and IL-23 in vitro and vivo with SAP. However, the intervention with EX527 (SIRT1 inhibitor) or r-HMGB1 (recombinant HMGB1) could obliviously reverse the above-mentioned influence of DCQD in SAP. In vitro, we confirmed that DCQD could decrease the acetylation, migration and release of HMGB1, and improve the decline of cell viability, SIRT1, SIRI-HMGB1 combination induced by cerulein with promoting macrophage to release IL-23 through HMGB1/TLR-4. ConclusionDCQD treatment improves SAP-induced pancreatic microcirculatory dysfunction by inhibiting neutrophil-mediated inflammation through the inactivation of HMGB1-TLR-4-IL-23-IL-17A signaling via Targeting SIRT1.Trial registration: No. 365, 2020.
WITHDRAWN: LC-MS-Based Urine Metabolomics for the Identification of Biomarkers Related to The Occurrence and Severity of Flight Fatigue
Authors: Gao Rong , Fan Jiao , Fu Zhaojun , Ma Yazhong , Wang Jianchang , Yuan Hailong 
Published: July 2021

Abstract
Background: Aircrew fatigue is a major contributor of operational errors in civil and military aviation, which translates a comprehensive performance associated with both neuromuscular and cognitive states. Here we have used untargeted and non-invasive urinary metabolomics to explore flight fatigue-related aberrations. In this sense, we aimed to identify biomarkers that could better monitor pilot fatigue and also assess its severity to prevent ‘nonfunctional over-reached’ state, thus promoting flight safety. Methods: In this study, 22 active-duty male pilots, who conducted different flight hour duties, were recruited to mimic different levels of fatigue. For this, respective urine samples were collected, before and after flight, and analyzed by liquid chromatography/mass spectrometry (LC/MS). Results: Except for the fatty acids and some amino acids, significant changes on metabolite levels were observed during the progression of flight fatigue. Most of these metabolites corresponded to acyl carnitines, carbohydrates, purines and indoles. The majority of amino acids were downregulated after the flight mission. A total of 61 metabolites were found to be significantly changed along with the extent of flight fatigue. To efficiently discriminate the occurrence of flight fatigue, three candidate biomarkers (beta-guanidinopropionic acid, 3-dehydro-L-gulonate and 2-propylpent-3-enoic acid) were further characterized. Lastly, Bayes discriminant function models were established to stratify pilots with severity of fatigue and, therefore, to aid in flight risk management.Conclusion: To our knowledge, this study inaugurally provides a metabolic profiling in response to flight fatigue, thus offering a novel and effective way to monitor and manage this physiological condition.
Mediating Role of Cerebellar Subregion Volume in the Relationship Between Gait Speed and Working Memory
Authors: Won Junyeon , Callow Daniel D. , Purcell Jeremy J. , Smith J. Carson 
Published: July 2021

Abstract
Introduction: The relationship between gait speed and working memory is well-understood in older adults. However, it remains to be determined whether this relationship also exists in younger adults; and there is little known regarding the possible neural mechanism underlying the association between gait speed and working memory. The aims of this study are to determine if there is: 1) an association between gait speed and working memory performance; and 2) a mediating role of cerebellar subregion volume in the correlation between gait speed and working memory in healthy younger adults.Methods: 1054 younger adults (28.7±3.6 years) from the Human Connectome Project were included in the analyses. A four-meter gait test was used to assess gait speed. The N-back task was conducted to measure working memory performance [accuracy and response time(RT)]. T1-weighted structural MRI data (obtained using Siemens 3T MRI scanner) was used to assess cerebellar subregion volumes. Linear regression and mediation analysis were used to examine the relationships between the variables after controlling for age, sex, and education. Results: Faster gait speed was associated with faster working memory RT in younger adults. Greater cerebellar subregion volumes were associated with faster gait speed and better working memory performance. Faster gait speed was correlated with faster working memory RT through greater volume of cerebellar region VIIIa. Conclusions: The present study suggests faster gait speed is associated with faster RT during working memory tasks in younger individuals. The specific subregion of the cerebellum (VIIIa) may serve as an important neural basis linking gait speed and working memory.
A Compilation and Characterisation of Lithic Populations in Common and Kimberlite Maar-Diatremes and their Tephra Ring Deposits
Authors: Fitzgerald Michelle Kathleen , White James Daniel Lee 
Published: July 2021

Abstract
Maar-diatreme volcanoes are the second-most common type on land, occurring in volcanic fields within all major tectonic environments. Their deposits typically contain an abundance of lithic fragments quarried from the substrate, and many contain large, deep-sourced lithic fragments that were erupted to the surface. Primary volcaniclastic deposits fill the diatreme structure formed during eruption. There is negligible inelastic deformation of diatreme-adjacent country rock, indicating that country rock is removed to create the diatreme structures, either by being shifting downward below observable levels, ejected upward to contribute to surficial deposits, or dissolved and hidden in magma erupted or intruded at depth. No previous study has systematically reviewed and analysed the reported lithic fragments of maar-diatreme systems. We present a comprehensive compilation from published work of lithic characteristics in maar ejecta rims and in diatreme deposits of both common and kimberlite maar-diatremes. For maar-diatremes and their tephra ring deposits, we find no correlations among lithic clast sizes, shapes, depositional sites, and excavation depths. This is difficult to reconcile with models involving systematic diatreme deepening coupled with tephra-ring growth, but consistent with those involving chaotic explosions and mixing. Larger amounts of data are needed to further examine how these types of volcanoes operate.
Intramedullary Nailing Combined With Adjunct Plate or Blocking Screw for Proximal Tibial Fractures
Authors: li Jie , Wang Qian , Li Zhong , Zhang Kun 
Published: July 2021

Abstract
Objective: To compare the traditional approach of intramedullary nail with an extra plate versus the nail combined with blocking screws for proximal tibia fractures without the knee involved. Methods: From January 2013 to January 2017, a total of 36 patients who suffered from proximal tibial fractures unaffecting the knee were enrolled into this prospective study, and divided into two groups by random number table method. Of them, 19 patients received an interlocking intramedullary nail combined with an extra plate for internal fixation of the fractures (the plate group), while the remaining 17 patients had fractures fixed with the nail combined with blocking screws (the screw group). The perioperative, follow-up and radiographic data were compared between the two groups. Results: All the 36 patients underwent operation smoothly without iatrogenic neurovascular injuries. The plate group proved superior the screw group regarding to operation time and intraoperative X-ray exposure (P＜0.05) , nevertheless the former was inferior to the latter in implant cost and hospital stay (P＜0.05) . The follow-up period lasted for 12～24 months with a mean of (15.62±4.71) months. There were no statistically significant differences in the time to return ambulation and the time to full weight-bearing activity between the two groups (P＞0.05) . At the latest follow up, no statistically significant differences were found between the two groups regarding knee range of motion and Johner-Wruhs grades for clinical consequences (P＞0.05) . In terms of anterior knee pain, the difference between the two groups was not statistically significant (P＞0.05) . In respect of radiographic assessment, the plate group had significantly less residual malalignment than the screw group, including anteroposterior and lateral displacements, as well as angulations in coronal and sagittal planes (P＜0.05) . To the latest follow up, all patients in both group got bony healing of the fractures without a statistical difference in fracture healing time between them (P＞0.05) , and no loosening or breaking of the implants were showed on images in anyone of them. Conclusion: Both the nail plus plate and nail plus blocking screw do achieve satisfactory clinical outcomes for proximal tibial fractures unaffecting the knee. By comparison, the nail combined with plate facilitates to regain and maintain better alignment of the leg regardless of higher implant cost.
Time-resolved Raman and luminescence spectroscopy of synthetic REE-doped hydroxylapatites and natural apatites
Authors: Fau Amaury , Beyssac Olivier , Gauthier Michel , Panczer Gérard , Gasnault Olivier , Meslin Pierre-Yves , Bernard Sylvain , Maurice Sylvestre , Forni Olivier , Boulliard Jean-Claude , Bosc Françoise , Drouet Christophe 
Published: July 2021

Abstract
Using continuous and time-resolved spectroscopy, we investigate Raman and luminescence signals from synthetic hydroxylapatites doped with trivalent REE including Dy3+, Eu3+, Nd3+, and Sm3+, as well as REE in natural apatites, with laser excitations at 532 and 785 nm. We demonstrate that time-resolved spectroscopy is an efficient method to reduce luminescence from Raman spectra or, alternatively, to investigate the luminescence signals without interference from the Raman contribution. Time-resolved luminescence spectroscopy is a powerful technique for generating specific high-quality luminescence spectra for the REE emission activators in apatites by using appropriate combinations of delay and gate width for time synchronization of the laser pulse and ICCD detector. This allows the unambiguous detection and identification of the activators by avoiding overlapping of various emission signals in the luminescence spectra. This is particularly useful in the case of natural samples, which often have several activators for luminescence. In the case of synthetic REE-doped apatites, a quenching process for luminescence due to activator concentration is seen for Eu3+ and Sm3+, i.e., the higher the concentration, the shorter the luminescence decay time. The interpretation of luminescence decay time in natural apatites is promising but more complex because of energy transfers between the various luminescence activators present in the crystal lattice. Luminescence is a powerful technique for detecting the presence of REE in apatites down to parts per million levels, though quantifying the concentration is still a challenge.
Single-crystal elasticity of phase Egg AlSiO3OH and δ-AlOOH by Brillouin spectroscopy
Authors: Wang Baoyun , Zhang Yanyao , Fu Suyu , Yan Wei , Takahashi Eiichi , Li Li , Lin Jung-Fu , Song Maoshuang 
Published: July 2021

AbstractPhase Egg and δ-AlOOH are two typical hydrous phases that might exist in the wet sedimentary layer of subducted slabs under mantle conditions. They are thus regarded as potential water carriers to Earth’s deep mantle. In this report, we report the full elastic constants of both phases determined by Brillouin scattering and X-ray diffraction measurements under ambient conditions. Our results indicate that the hydrogen-bond configurations in the crystal structures of the two phases have a profound effect on their principal elastic constants. The adiabatic bulk modulus (KS) and shear modulus (G) calculated from the obtained elastic constants using the Voigt-Reuss-Hill averaging scheme are 158.3(201) GPa and 123.0(60) GPa for phase Egg and 162.9(31) GPa and 145.2(13) GPa for δ-AlOOH, respectively. These results allow us to evaluate elastic moduli and sound velocities of hydrous minerals in the Al2O3-H2O-SiO2 ternary system (simplified composition of subducted wet sedimentary layer) at ambient conditions, including the contrast of the acoustic velocities VP and VS for the reaction AlSi3OH = δ-AlOOH + SiO2 (stishovite) and the evolution in the elastic moduli and sound velocities of hydrous minerals as a function of density.
Crystal-chemical reinvestigation of probertite, CaNa[B5O7(OH)4]·3H2O, a mineral commodity of boron
Authors: Gatta G. Diego , Cannaò Enrico , Gagliardi Valentina , Fabelo Oscar 
Published: July 2021

Abstract
The crystal chemistry of probertite, a mineral commodity of B (B2O3 ~50 wt%) with ideal formula CaNa[B5O7(OH)4]·3H2O from the Kramer Deposit (Kern County, California, type locality), was investigated by a multi-methodological approach [i.e., single-crystal X-ray (at 293 K) and neutron (at 20 K) diffraction, EPMA-WDS, LA-ICP-MS, and LA-MC-ICP-MS]. As recently determined for other hydrous borates, the real chemical formula of probertite from the Kramer Deposit is virtually ideal, i.e., the fractions of other elements are insignificant. Therefore, excluding B, probertite does not act as a geochemical trap of other industrially relevant elements (e.g., Li, Be, or REE). Our experimental results confirm that the structure of probertite is built up by the so-called pentaborate polyanion [B5O7(OH)4]3− (topology: 5(2Δ + 3T)], which consists of oxygen-sharing B-tetrahedra and B-triangular units. The five (geometrical) components of the polyanion are BO3, BO2OH, BO4, BO3OH, and BO2(OH)2 groups. The pentaborate building units are connected to form chains running along [100]. Clusters of distorted Ca-polyhedra [CaO5(OH)3(OH2), CN = 9] and Na-polyhedra [NaO(OH)2(OH2)3, CN = 6] are mutually connected by edge-sharing and, in turn, connected to the pentaborate chains by edge-sharing (with the Ca-polyhedron) and corner-sharing (with the Na-polyhedron). The hydrogen-bonding scheme of the probertite structure is complex and pervasive, with 10 independent H sites (belonging to hydroxyl groups or H2O molecules) and 11 of the 14 oxygen sites being involved in H-bonds as donor or acceptors. Hence, the H-bonding network likely plays an important role in the stability of probertite. In addition, the potential utilizations of probertite are discussed.
Sulodexide in the treatment of post-thrombotic disease complicated by the development of trophic defects of the lower extremities in patients with COVID-19 pneumonia
Authors: Zudin A. M. , Shapoval A. S. 
Published: July 2021

Introduction. The problem of care for patients with trophic venous ulcers remains an urgent medical and social problem, which has been aggravated again against the background of the COVID-19 pandemic in 2020-2021. As is now known, after a COVID-19 viral infection, most patients with cardiovascular diseases experience a significant exacerbation of these ailments. This is also true for postthrombotic lower extremity disease (PTD). Many patients with edematous or edematous-painful forms of PTB after COVID-19-associated pneumonia experience formation of trophic ulcers of the distal parts of the lower extremities.Aim. To study characteristic features of the course of ulcerative process in PTB in patients after COVID-19-associated pneumonia and to search safe and effective means, accelerating wound epithelialization in such patients.Material and methods. Efficiency of sulodexide use in conservative therapy of 16 patients with PTB, in whom trophic defects (venous ulcers) of the lower third of the shin and foot first appeared after pneumonia due to SARS-CoV-2 infection, was evaluated. At the same time, trophic ulcers were highly resistant to conventional therapy aimed at their healing. All 16 patients were unable to achieve epithelialization more than one month after the occurrence of trophic ulcers. Results. According to the results of this study it was found that the use of sulodexide as an angiotropic agent having, among other things, anti-inflammatory effect on the vessel wall in patients with trophic ulcers formed after COVID-19-associated pneumonia is justified.Conclusions. The treatment of trophic defects of the lower limbs in patients with PTB after COVID-19-associated pneumonia has a number of regular features. Sulodexide showed high efficacy as an angiotropic agent, whose pharmacological properties are adequate to the pathogenesis of trophic ulcers taking into account the course of infection caused by SARS-CoV-2.
Design flood estimation with varying record lengths in Norway under stationarity and nonstationarity scenarios
Authors: Yan Lei , Xiong Lihua , Ruan Gusong , Zhang Mengjie , Xu Chong-Yu 
Published: July 2021

AbstractIn traditional flood frequency analysis, a minimum of 30 observations is required to guarantee the accuracy of design results with an allowable uncertainty, however, there has not been a recommendation for the requirement on the length of data in NFFA (nonstationary flood frequency analysis). Therefore, this study has been carried out with three aims: (i) to evaluate the predictive capabilities of nonstationary (NS) and stationary (ST) models with varying flood record lengths; (ii) to examine the impacts of flood record lengths on the NS and ST design floods and associated uncertainties; and (iii) to recommend the probable requirements of flood record length in NFFA. To achieve these objectives, 20 stations with record length longer than 100 years in Norway were selected and investigated by using both GEV (generalized extreme value)-ST and GEV-NS models with linearly varying location parameter (denoted by GEV-NS0). The results indicate that the fitting quality and predictive capabilities of GEV-NS0 outperform those of GEV-ST models when record length is approximately larger than 60 years for most stations, and the stability of the GEV-ST and GEV-NS0 is improved as record lengths increase. Therefore, a minimum of 60 years of flood observations is recommended for NFFA for the selected basins in Norway.