bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early suppression of the endocannabinoid degrading enzymes FAAH and MAGL alters locomotor development in zebrafish
Authors: Sufian M. Shah , Amin M. Ruhul , Ali Declan W. 
Published: June 2021

ABSTRACT
The fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) enzymes are the predominant catabolic regulators of the major endocannabinoids (eCBs) anadamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. The expression and roles of eCBs during early embryogenesis remain to be fully investigated. Here, we inhibited FAAH and MAGL in zebrafish embryos during the first 24 h of life and examined motor neuron and locomotor development at 2 and 5 days post fertilization (dpf). Application of the dual FAAH/MAGL inhibitor, JZL195 (2 µmol l−1), resulted in a reduction in primary and secondary motor neuron axonal branching. JZL195 also reduced nicotinic acetylcholine receptor (nAChR) expression at neuromuscular junctions. Application of URB597 (5 µmol l−1), a specific inhibitor of the FAAH enzyme, also decreased primary motor neuron branching but did not affect secondary motor neuron branching and nAChR expression. Interestingly, JZL184 (5 µmol l−1), a specific inhibitor of MAGL, showed no effects on motor neuron branching or nAChR expression. Co-treatment of the enzyme inhibitors with the CB1R inhibitor AM251 confirmed the involvement of CB1R in motor neuron branching. Disruption of FAAH or MAGL reduced larval swimming activity, and AM251 attenuated the JZL195- and URB597-induced locomotor changes, but not the effects of JZL184. Together, these findings indicate that inhibition of FAAH, or augmentation of AEA acting through CB1R during early development, may be responsible for locomotor deficiencies.
Community-based care models for arterial hypertension management in non-pregnant adults in sub-Saharan Africa: A scoping review protocol
Authors: González Fernández Lucia , Firima Emmanuel , Huber Jacqueline , Raeber Fabian , Amstutz Alain , Gupta Ravi , Mokhohlane Joalane , Belus Jennifer M. , Labhardt Niklaus Daniel 
Published: June 2021

Introduction: Arterial hypertension (aHT) is the most important cardiovascular risk factor (CVRF) in adults living in sub-Saharan Africa (SSA), leading to an excess of cardiovascular disease (CVD) morbidity and mortality. Life-long aHT service delivery models in the region remain mostly anchored to health facilities and are provided by physicians or nurses, thus limiting access to care. Over the past years, decentralized community-based aHT care models have been piloted, aiming to improve access to prevention, diagnosis, and treatment. Although individual studies suggest that community-based care is well-received and potentially efficacious, a synthesized overview of such care models is missing. Hence, the aim of this scoping review is to map out and summarize existing interventions for community-based aHT diagnosis and care in non-pregnant adults in SSA. Additionally, we will describe outcomes in terms of acceptability, blood pressure control, patient engagement in care, and occurrence of aHT caused end-organ damage. Methods and analysis: We will apply the Arksey and O’Malley scoping review methodology and best practice, as outlined by Levac and the Joanna Briggs Institute scoping review guidelines. The research questions have been identified through a literature review and expert consultation. A systematic literature search will be conducted in four databases using a tailored search strategy, including a supplemental search through backward and forward citation. Abstracts and full text screening as well as the extraction of data will be conducted by two independent reviewers. Discrepancies will be resolved by a third reviewer. Information will be presented in both tabular and narrative form. Ethics and dissemination: This scoping review will summarize findings from existing publications, rather than primary data, and as such, does not require ethics review. Findings will be disseminated through stakeholder meetings, conference presentations, websites, and a peer-reviewed publication.
Assessment of exposure determinants and exposure levels by using stationary concentration measurements and a probabilistic near-field/far-field exposure model
Authors: Koivisto Antti Joonas , Spinazzè Andrea , Verdonck Frederik , Borghi Francesca , Löndahl Jakob , Koponen Ismo Kalevi , Verpaele Steven , Jayjock Michael , Hussein Tareq , Lopez de Ipiña Jesus , Arnold Susan , Furxhi Irini 
Published: June 2021

Background: The Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation requires the establishment of Conditions of Use (CoU) for all exposure scenarios to ensure good communication of safe working practices. Setting CoU requires the risk assessment of all relevant Contributing Scenarios (CSs) in the exposure scenario. A new CS has to be created whenever an Operational Condition (OC) is changed, resulting in an excessive number of exposure assessments. An efficient solution is to quantify OC concentrations and to identify reasonable worst-case scenarios with probabilistic exposure modeling. Methods: Here, we appoint CoU for powder pouring during the industrial manufacturing of a paint batch by quantifying OC exposure levels and exposure determinants. The quantification was performed by using stationary measurements and a probabilistic Near-Field/Far-Field (NF/FF) exposure model. Work shift and OC concentration levels were quantified for pouring TiO2 from big bags and small bags, pouring Micro Mica from small bags, and cleaning. The impact of exposure determinants on NF concentration level was quantified by (1) assessing exposure determinants correlation with the NF exposure level and (2) by performing simulations with different OCs. Results: Emission rate, air mixing between NF and FF and local ventilation were the most relevant exposure determinants affecting NF concentrations. Potentially risky OCs were identified by performing Reasonable Worst Case (RWC) simulations and by comparing the exposure 95th percentile distribution with 10% of the occupational exposure limit value (OELV). The CS was shown safe except in RWC scenario (ventilation rate from 0.4 to 1.6 1/h, 100 m3 room, no local ventilation, and NF ventilation of 1.6 m3/min). Conclusions: The CoU assessment was considered to comply with European Chemicals Agency (ECHA) legislation and EN 689 exposure assessment strategy for testing compliance with OEL values. One RWC scenario would require measurements since the exposure level was 12.5% of the OELV.
ФОРМИРОВАНИЕ БЕЗОПАСНОГО СОЦИАЛЬНОГО ПОВЕДЕНИЯ ДОШКОЛЬНИКОВ В ИНКЛЮЗИВНОЙ ОБРАЗОВАТЕЛЬНОЙ СРЕДЕ
Authors: Silaeva Olga A. 
Published: June 2021

Цель исследования состояла в разработке, реализации и проверке эффективности программы психолого-педагогического сопровождения детей дошкольного возраста, разработанной на основе системы формирования безопасного социального поведения в инклюзивной образовательной среде. В исследовании приняли участие 45 человек в возрасте 5-7 лет, воспитанники средних дошкольных и подготовительных групп. В каждой группе среди воспитанников было от 3 до 4 детей с отклонениями в развитии (умственная отсталость / задержка психического развития, синдром Дауна, расстройства аутистического спектра).
Методологическую основу разработки психолого-педагогической программы положен принцип инегративности – интеграция межпредметных областей (социально-коммуникативное развитие, познавательное развитие, физическое развитие); гибкое сочетание воспитательной и коррекционной работы и инклюзивного образования; интеграция двигательной и познавательной активности.
Методы исследования: психолого-педагогический эксперимент; психодиагностические методики (Диагностика толерантности у детей дошкольного возраста по отношению к сверстникам с ограниченными возможностями здоровья (А.С. Сиротюк); Исследование тревожности ребенка дошкольного возраста (Р. Тэммл, М. Дорки, В. Амен) (модификация Т.Д. Марцинковской в авторской интерпретации); Методика рисуночной фрустрации С. Розенцвейга); Методика определения степени включенности старших дошкольников в игровое взаимодействие со сверстником (С.Г. Елизаров, модификация С.С. Журавлевой); Рисуночная методика «Я в детском саду» (М. Быкова, М. Аромштам).
Результаты работы. Установлено, что процесс формирования у дошкольников безопасного социального поведения в инклюзивной образовательной среде при взаимодействии со сверстниками с отклонениями в развитии состоит из трех взаимосвязанных этапов (адаптационный, мотивационно-информационный, практико-ориентированный), предполагающих развитие потребностно-мотивационной, эмоционально-волевой, когнитивно-познавательной и межличностно-социальной сфер детей дошкольного возраста.
Область применения: система дошкольного образования.
НЕЙРОПСИХОЛОГИЧЕСКАЯ КОРРЕКЦИЯ ПЕРВОКЛАССНИКОВ С ДИАГНОЗОМ НЕЙРОСЕНСОРНАЯ ПОТЕРЯ СЛУХА, ОБУЧАЮЩИХСЯ ПО СИСТЕМЕ ИНКЛЮЗИВНОГО ОБРАЗОВАНИЯ
Authors: Senchenko Galina V. , Lazarian Varsena V. , Senchenko Alexey Yu. 
Published: June 2021

Одной из наиболее распространенных групп детей с ОВЗ составляют дети с нарушениями слуха. Начало учебы в школе для слабослышащего ребенка требует дополнительных усилий по его адаптации как со стороны самого ребенка, так и со стороны педагогов и родителей. В статье представлены результаты нейропсихологической диагностики высших психических функций детей с диагнозом нейросенсорная потеря слуха (H90), обучающихся в 1-ом классе по системе инклюзивного образования.
Цель. Оценка уровня развития высших психических функций первоклассников с нейросенсорной потерей слуха до и после проведения программы нейропсихологической коррекции.
Материалы и методы исследования. В исследовании приняли участие 16 первоклассников, которым выставлен диагноз нейросенсорная потеря слуха, из них 11 мальчиков (68,8%) и 5 девочек (31,2%) в возрасте 8-9 лет. Нейропсихологическая диагностика детей проводилась с использованием нейропсихологического альбома Ж.М. Глозман и А.Е. Соболевой. Диагностика проводилось до и после проведения программы нейропсихологической коррекции.
Результаты. При первичной диагностике детей выявлено: нарушение слухоречевой памяти; нарушение акустического гнозиса; нарушение квазипространсвенного представления и др. С учётом нейропсихологических особенностей этих детей мы разработали для них коррекционную программу. У первоклассников с нарушением слуха, прошедших нейропсихологическую коррекцию отмечается: улучшение в ориентирование в собственной личности и окружающем мире, улучшение динамического праксиса и праксиса поз, улучшение зрительного восприятия и понимания логико-грамматических конструкций, предложных конструкций, повысилась продуктивность запоминания, стало доступнее обобщение и решение задач.
Выводы. 1. Первоклассники с диагнозом нейросенсорная потеря слуха, имеют отставания в развитии ВПФ. 2. Программа нейропсихологической коррекции направлена не только на развитие нарушенных ВПФ, но и на увеличение адаптационных возможностей детей с нарушением слуха. 3. У детей, прошедших нейропсихологическую коррекцию, выявлено значительное улучшение в пробах и уровне усвояемости школьной программы.
Область применения результатов. Результаты исследования могут быть использованы в работе педагогов и психологов, чья деятельность связана с обучением слабослышащих детей.
Personality traits of law enforcement officers serving in the North Caucasus region
Authors: Zhuk Kristina , Maltseva Tatyana 
Published: June 2021

When performing tasks by an employee in special conditions of service, not only professional qualities and compliance with qualification requirements, but also a psychologically stable state (psychological readiness to act in extreme situations, neuropsychic stability, mental adaptation, etc.) play an important role.
The purpose of the study was to study the personality traits of employees of the internal affairs bodies of the Russian Federation serving in the North Caucasus region.
In the study, we used the following empirical methods: G. Shmishek's questionnaire for adults, the forecast (Prognoz) -1 questionnaire (express assessment of neuropsychic stability), a modified (extended) version of the ITO questionnaire (KV Sugonyaev's modification).
In total, 184 employees who served in the Republic of Dagestan in 2019-2020 took part in the study. For situational reasons, this sample was divided into three subgroups: 45 employees, 79 employees and 60 employees.
In the process of selecting employees sent to the North Caucasus region, it is necessary to study the characteristics of neuropsychic stability, character accentuations, the level of anxiety, behavior, this will make it possible to predict the quality of training of law enforcement officers, the reliability of the employee's behavior, and contribute to his success in stressful conditions.
For the purposes of primary prevention, employees for whom a high level of anxiety is characteristic, a low level of neuropsychic stability should be excluded from those sent on business trips to special conditions of service.
Simple high-sensitivity optical fiber humidity sensor
Authors: Guo Jiachen , Chang Min , Xiao Yinfeng , Song Qiuheng , Zhao Dong , Jia Bo 
Published: June 2021

A new optical fiber humidity sensor with high sensitivity is reported. We effectively control the light-intensity changes in a smaller sensing area and achieve a significant increase in sensitivity by adjusting the depth of the evanescent field of the tapered fiber. The sensor is designed with an 8 µm diameter single-mode tapered fiber structure coated with a thickness of a 10 mm length carbomer layer in the tapered area. The average and maximum relative humidity (RH) sensitivities are 2.59 dB/%RH and 5.43 dB/%RH in the range of 68%–90%. To our best knowledge, the sensitivity of the sensor is highest compared with that of the previously reported. Moreover, the fast response time and recovery time of the sensor are ideal. In addition, the proposed humidity sensor has good repeatability and lower-temperature cross talk. Due to the excellent indicators, the proposed sensor has promising potential for highly sensitive RH sensing applications, especially early warning of special environments.
Evaluation of improved coloured targets to control riverine tsetse in East Africa: A Bayesian approach
Authors: Santer Roger D. , Okal Michael N. , Esterhuizen Johan , Torr Steve J. 
Published: June 2021

BackgroundRiverine tsetse (Glossinaspp.) transmitTrypanosoma brucei gambiensewhich causes Gambian Human African Trypanosomiasis. Tiny Targets were developed for cost-effective riverine tsetse control, and comprise panels of insecticide-treated blue polyester fabric and black net that attract and kill tsetse. Versus typical blue polyesters, two putatively more attractive fabrics have been developed: Vestergaard ZeroFly blue, and violet. Violet was most attractive to savannah tsetse using large targets, but neither fabric has been tested for riverine tsetse using Tiny Targets.MethodsWe measured numbers ofG.f.fuscipesattracted to electrified Tiny Targets in Kenya and Uganda. We compared violets, Vestergaard blues, and a typical blue polyester, using three replicated Latin squares experiments. We then employed Bayesian statistical analyses to generate expected catches for future target deployments incorporating uncertainty in model parameters, and prior knowledge from previous experiments.ResultsExpected catches for average future replicates of violet and Vestergaard blue targets were highly likely to exceed those for typical blue. Accounting for catch variability between replicates, it remained moderately probable (70–86% and 59–84%, respectively) that a given replicate of these targets would have a higher expected catch than typical blue on the same day at the same site. Meanwhile, expected catches for average violet replicates were, in general, moderately likely to exceed those for Vestergaard blue. However, the difference in medians was small, and accounting for catch variability, the probability that the expected catch for a violet replicate would exceed a Vestergaard blue equivalent was marginal (46–71%).ConclusionViolet and Vestergaard ZeroFly blue are expected to outperform typical blue polyester in the Tiny Target configuration. Violet is unlikely to greatly outperform Vestergaard blue deployed in this way, but because violet is highly attractive to both riverine and savannah tsetse using different target designs, it may provide the more suitable general-purpose fabric.
On a nonlinear relation for computing the overpartition function
Authors: Merca Mircea 
Published: June 2021

Abstract
In 1939, H. S. Zuckerman provided a Hardy-Ramanujan-Rademacher-type convergent series that can be used to compute an isolated value of the overpartition function
p
(n). Computing
p
(n) by this method requires arithmetic with very high-precision approximate real numbers and it is complicated. In this paper, we provide a formula to compute the values of
p
(n) that requires only the values of
p
(k) with k ≤ n/2. This formula is combined with a known linear homogeneous recurrence relation for the overpartition function
p
(n) to obtain a simple and fast computation of the value of
p
(n). This new method uses only (large) integer arithmetic and it is simpler to program.
External Training Load Monitoring and the Impact on Training Load Management in Collegiate Male Soccer Players
Authors: Gdovin Jacob R. , Galloway Riley , Tomasiello Lorenzo S. , Seabolt Michael , Booker Robert 
Published: June 2021

Abstract
Gdovin, JR, Galloway, R, Tomasiello, LS, Seabolt, M, and Booker, R. External training load monitoring and the impact on training load management in collegiate male soccer players. J Strength Cond Res XX(X): 000–000, 2023—Soccer is a physically demanding sport within the National Collegiate Athletic Association and continuously increases in popularity. To ensure athletes are adequately prepared for weekly physical stressors, coaches can use global positioning system technology to monitor external workloads and exercise intensity. These data can subsequently help coaches and practitioners better implement individualized training programs to ensure athletes are properly balancing the overreaching and overtraining paradigm. Therefore, the purpose of this observational study was to retrospectively analyze 3 consecutive seasons of external workload (total and high intensity distance) and injury data, which were derived from all training sessions and matches in 46 Division-I collegiate male soccer players. A coach's interpretation sought to provide practical insight into the functionality behind load management and how it prepares athletes for the physical stressors placed on them throughout a season. Two separate 3 × 3 repeated measures ANOVAs were conducted to determine differences between total distance and distance at high-intensity with an alpha level set at 0.05. Total distance between preseason and in-season (p = 0.003), acute high-intensity distance (p < 0.001), and chronic high-intensity distance (p < 0.001) yielded significant differences. These results conclude the demands of each athlete change weekly and between seasons. It is recommended that sport coaches and practitioners develop individualized training programs by workload monitoring while considering variables such as a team's style of play, experience, position, role within a program, training intensity, and the length of time between conditioning sessions, practices, and matches.
Rescuing Auditory Temporal Processing with a Novel Augmented Acoustic Environment in an Animal Model of Congenital Hearing Loss
Authors: Dziorny Adam C. , Luebke Anne E. , Scott Luisa L. , Walton Joseph P. 
Published: June 2021

AbstractCongenital sensorineural hearing loss (SNHL) affects thousands of infants each year and results in significant delays in speech and language development. Previous studies have shown that early exposure to a simple augmented acoustic environment (AAE) can limit the effects of progressive SNHL on hearing sensitivity. However, SNHL is also accompanied by hearing loss that is not assessed on standard audiological examinations, such as reduced temporal processing acuity. To assess whether sound therapy may improve these deficits, a mouse model of congenital SNHL was exposed to simple or temporally complex AAE. The DBA/2J mouse strain develops rapid, base to apex, progressive SNHL beginning at birth and is functionally deaf by six months of age. Hearing sensitivity and auditory brainstem function was measured using otoacoustic emissions, auditory brainstem response (ABR) and extracellular recording from the inferior colliculus (IC) in mice following exposure to 30 d of continuous AAE. Peripheral function and sound sensitivity in auditory midbrain neurons improved following exposure to both types of AAE. However, exposure to a novel, temporally complex AAE more strongly improved a measure of temporal processing acuity, neural gap-in-noise detection in the auditory midbrain. These experiments suggest that targeted sound therapy may be harnessed to improve hearing outcomes for children suffering from congenital SNHL.
The Physical Health of Caregivers of Children With Life-Limiting Conditions: A Systematic Review
Authors: Hartley Julie , Bluebond-Langner Myra , Candy Bridget , Downie Jonathan , Henderson Ellen M 
Published: June 2021

CONTEXT
Parental caregiving for a child with a life-limiting condition (LLC) is complex physical and mental work. The impact of this caregiving on parents’ physical health is unknown.

OBJECTIVES
(1) To review existing evidence on the physical health of parents caring for a child with a LLC and (2) to determine how physical health of parents is measured.

DATA SOURCES
Medline, Embase, PsycINFO, and Cumulative Index of Nursing and Allied Health Literature were searched.

STUDY SELECTION
Peer-reviewed articles were included if they reported primary data on the physical health of a caregiver of a child with a LLC. Studies were excluded if they described only the caregiver’s mental health or if the caregivers were bereaved at the time of data collection.

DATA EXTRACTION
Of 69 335 unique citations, 81 studies were included in the review.

RESULTS
Caregiver health was negatively impacted in 84% of studies. Pain and sleep disturbance were the most common problems. Ways of measuring the physical health of caregiver varied widely. We found an absence of in-depth explorations of the social and economic contexts, which could potentially mitigate the impact of caregiving. Furthermore, we find health interventions tailored to this group remain largely unexplored.

LIMITATIONS
Studies were heterogenous in methodology, making comparisons of results across studies difficult.

CONCLUSIONS
These findings support the need for improving access to interventions aimed at improving physical health in this population. The rate of health-seeking behaviors, preventive health care access and screening for health conditions is understudied and represent important directions for further research.