bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical results of using a silver-containing preparation as part of an antimicrobial spacer in the treatment of periprosthetic hip joint infection
Authors: Bozhkova S. A. , Gadzhimagomedov M. Sh. , Tikhilov R. M. , Artyukh V. A. , Antipov A. P. , Afanasyev A. V. , Toropov S. S. , Muravyeva Yu. V. 
Published: December 2024

Introduction Periprosthetic infection (PPI) is one of the most serious complications of primary arthroplasty. Its rates range between 1.1 and 2 %. This study presents a comparative analysis of the results of the sanitizing stage of two-stage treatment of patients with chronic PPI of the hip joint (HJ) using an antimicrobial spacer impregnated with highly dispersed silver and without its impregnation.Purpose To conduct a comparative analysis of the clinical efficacy of using HD-Ag for impregnation of an antimicrobial spacer in patients with chronic PPI HJ during the sanitizing stage.Materials and methods A retrospective study is based on the analysis of the treatment outcomes of 223 patients with PPI HJ with antimicrobial spacers implanted during the sanitizing stage. Two groups of patients were formed based on the impregnation of bone cement with only an antibiotic or its combination with HD-Ag, group 1 (n = 112) and group 2 (n = 111), respectively. The evaluation of the treatment outcomes at a follow-up period of at least 2 years was carried out in accordance with the modified Delphi criteria. The reliability of differences in quantitative parameters between the groups was analyzed using nonparametric Mann – Whitney test, whereas Fisher test was used to analyze relative indicators. The differences were considered significant at p < 0.05.Results The spectrum of pathogens was comparable in both groups. The recurrence rate in groups 1 and 2 was 23.2 % and 17.1 %, respectively (p > 0.05), while for monobacterial infection caused by gram-positive bacteria it was significantly lower in group 2 (p = 0.012).Discussion As reported, the recurrence rate of periprosthetic infection varies from 8 to 40 %, depending on the nature of the infectious process and the type of pathogen. In the group with the use of HD-Ag as part of an antimicrobial spacer, the effectiveness of the sanitizing stage was 82.9 % and in the comparison group it was 76.8 %. However, a subanalysis of the effect of the etiology of PPIs on treatment results showed that the use of AM-spacer with a combination of silver and vancomycin led to a statistically significant reduction in the risk of recurrence in patients with monobacterial infection caused by gram-positive pathogens and provided arrest of infection in 89.7 % of cases.Conclusion In the sanitizing stage of two-stage treatment of chronic peri-implant hip infection caused by gram-positive bacteria, the antimicrobial cement spacer impregnated with highly dispersed silver showed high efficiency. However, further development of new combinations for bone cement impregnation is required to expand the spectrum of antimicrobial activity of the spacers.
Results of minimally invasive core decompression and autologous bone grafting in combination with autologous bone marrow aspirate concentrate in the treatment of patients with aseptic osteonecrosis of the femoral head
Authors: Naida D. A. , Tyulkevich B. V. , Malanin D. A. , Kondrashenko V. V. , Demeshchenko M. V. , Chirkov N. N. 
Published: December 2024

Introduction Currently, limb salvage methods have been used for the treatment of aseptic osteonecrosis of the femoral head (ANFH), but their use does not always avoid joint replacement in the later stages of the disease. The combination of core decompression and autologous bone grafting with autologous bone marrow aspirate concentrate (BMAC) in the treatment of patients with ANFH could improve their quality of life, delay joint replacement, or, in some cases, avoid it completely.Purpose To evaluate the results of surgical treatment of patients with ANFH using minimally invasive core decompression and autologous bone grafting in combination with BMAC, develop an algorithm for choosing a method of surgical treatment based on the extent of damage to the femoral head and the stage of the disease.Material and methods A pilot multicenter study included 86 patients diagnosed with ANFH. All patients underwent minimally invasive core decompression in combination with autologous bone grafting and BMAC. Results were analyzed 3, 6, 12 months after surgery.Discussion Due to the fact that the presented study included mainly patients with post-Covid and steroidinduced osteonecrosis, and did not include patients with the first stage of the disease, the percentage of positive treatment results was slightly lower compared to other similar studies.Results Within 3 to 6 months after surgery, 21 patients (24 %) required joint replacement; among the remaining 65 patients (76 %), there was a significant improvement in the condition and quality of life that was confirmed by instrumental studies and functional assessment.Conclusion The technique of minimally invasive core decompression and autologous bone grafting in combination with BMAC is an effective method of treatment patients with pre-collapse ANFH stages, might improve their quality of life but does not allow regression of structural changes in the bone.
Release of antibiotics from the materials for postosteomyelitic bone defect filling
Authors: Stogov M. V. , Shastov A. L. , Kireeva E. A. , Tushina N. V. 
Published: December 2024

Introduction The search for materials for bone defect filling that would provide a release of antibiotics in therapeutic levels over a long period is a pressing issue in the treatment of patients with osteomyelitis.The purpose of the work was to compare the kinetics of antibiotic release from materials based on polyurethane polymers for filling post-osteomyelitic bone defects.Materials and methods A comparative in vitro analysis of the kinetic release of cefotaxime, vancomycin, and meropenem from two materials was performed: one was based on polyurethane polymers (RK series) and the other on polymethyl methacrylate (PMMA series). In each series, antibiotics were added to the original materials in three proportions: polymer/ antibiotic — 10:1 (group 1); 10:0.5 (group 2), and 10:0.25 (group 3). The samples were incubated in 10 ml of saline at 37 °C. The incubation solution was changed daily during the first week, and then once a week. Six samples were incubated in each group.Results It was revealed that the volume of eluted cefotaxime in the PMMA series was higher than in the RK series for all antibiotic concentrations. In turn, for vancomycin and meropenem, it was observed only for group 1 samples. For groups 0.5 and 0.25, a larger volume of released antibiotics was noted in the RK series than in the PMMA series. It was found that in the RK series, the release of vancomycin and cefotaxime in an effective (therapeutic) concentration was more prolonged. In the RK series, there was prolonged release of effective concentrations but in a smaller volume of released antibiotic than in the PMMA series.Discussion Each material showed its own antibiotic elution profile and each of them may have its own indications. The RK-based material has advantages in terms of the duration of antibiotic elution in therapeutic doses.Conclusion The release of the studied antibiotics in effective concentrations from the material based on polyurethane polymers is longer than from the PMMA-based material.
ANALISIS PERSEDIAAN BAHAN BAKU TEPUNG TERIGU DENGAN MENGGUNAKAN METODE ECONOMIC ORDER QUANTITY (Studi Kasus di UD. Elza Putra Food)
Authors: Kuswardhani Nita , Sapta Muhammad Sadam Putra , Choiron Miftahul 
Published: December 2024

Tujuan penelitian dilakukan untuk mengetahui hasil perbandingan pengendalian persediaan bahan baku tepung terigu menggunakan metode Economic Order Quantity (EOQ) dan metode konvensional, mengetahui reorder point dan safety stock bahan baku tepung terigu pada UD. Elza Putra Food, dan mengetahui perbedaan biaya persediaan bahan baku tepung terigu sebelum dan sesudah menggunakan metode Economic Order Quantity (EOQ) pada UD. Elza Putra Food. Pengendalian bahan baku masih menggunakan sistem konvensional berdasarkan pesanan sebelumnya dan jumlah stok bahan baku menjadi permasalahan UD. Elza Putra Food sehingga berisiko kehabisan stok. Penelitian ini dilakukan melalui beberapa tahapan penelitian meliputi studi lapangan, studi pustaka, identifikasi masalah, simpulan dan saran serta dianalisis menggunakan metode Economic Order Quantity (EOQ). Penerapan metode EOQ total biaya persediaan dapat diminimumkan sebesar Rp. 401.733, jumlah pemesanan lebih banyak 118 zak dengan frekuensi pemesanan 14 kali, persediaan pengaman sebanyak 28 zak dan titik pemesanan ulang saat bahan baku tersisa 41 zak. Sedangkan metode konvensional mengeluarkan total biaya sebesar Rp. 1.340.161, jumlah pemesanan sebanyak 36 zak dengan frekuensi pemesanan 48 kali, dan titik pemesanan ulang saat bahan baku tersisa 10 zak tanpa persediaan pengaman. Hasil perbandingan menunjukkan bahwa penerapan EOQ jumlah pemesanan lebih banyak 82 zak, persediaan pengaman sebanyak 28 zak, titik pemesanan ulang sebanyak 31 zak, dan frekuensi pemesanan lebih sedikit 34 kali.
ANALISIS KEPUASAN KONSUMEN ROTI AMIRAH BAKERY DI KABUPATEN TULUNGAGUNG
Authors: Hapsari Shinta Syafrina Endah , Amilia Winda , Wiyono Andi Eko , Zuhriyah Anis K 
Published: December 2024

Semakin pesatnya persaingan usaha pada perusahaan roti menjadikan perusahaan dituntut untuk terus meningkatkan mutu/kualitas produknya. Amirah Bakery merupakan salah satu industri roti yang hingga kini masih berdiri di Kabupaten Tulungagung dan konsisten melakukan pengembangan terhadap bisnisnya dengan mengedepankan kepuasan pelanggan sebagai prioritas utamanya. Penelitian ini diharapkan dapat menjawab tingkat kepuasan konsumen roti Amirah Bakery; prioritas atribut produk dan layanan Amirah Bakery; dan rekomendasi perbaikan yang dapat implementasikan di Amirah Bakery untuk menunjang keberlanjutan bisnisnya. Metode yang digunakan dalam penelitian ini yaitu CSI (Customer Satisfaction Index), dan Importance Performance Analysis (IPA). Alat penelitian yang digunakan berupa kuesioner, dan hasil penelitian menunjukkan bahwa pelanggan sangat puas dengan kualitas roti Amirah Bakery dengan nilai CSI sebesar 81,73%, dan perbaikan yang harus diutamakan berdasarkan Importance Performance Analysis adalah atribut 9, 10 dan 20, yaitu kemasan roti, warna roti dan performa pelayanan karyawan toko. Adapun rekomendasi perbaikan yang dapat dilakukan antara lain: mendesain ulang kemasan, mengembangkan inovasi produk, dan perlu adanya himbauan kepada karyawan untuk memahami perilaku yang ideal dalam bekerja.
Open Reduction and Orthogonal Tension Band Plating of an Isolated Periprosthetic Tibial Tubercle Fracture
Authors: Chen Xiao T. , Jackowski Jacob R. , Wahlig Brian D. , Sems Stephen A. , Yuan Brandon J. , Hidden Krystin A. 
Published: December 2024

Case:
A 67-year-old woman sustained a periprosthetic tibial tubercle avulsion fracture with extensor mechanism disruption. She underwent open reduction internal fixation (ORIF) with orthogonal mini-fragment plates applied in a tension band fashion with patellar tendon suture augmentation. Radiographs, range of motion, and patient-reported outcomes were completed over 1 year.

Conclusion:
Isolated periprosthetic tibial tubercle fractures with disruption of the extensor mechanism can be treated with ORIF using orthogonal tension band plating. At 1-year follow-up, the surgical technique described in this report yielded radiographic union, clinical restoration of preinjury motion, and excellent patient-reported outcomes.
PENGUJIAN TURBIN ANGIN DENGAN VARIASI KECEPATAN ANGIN, PUTARAN MOTOR DAN PUTARAN GENERATOR DENGAN MENGGUNAKAN TEROWONGAN ANGIN JENIS HORIZONTAL 3 BLADE
Authors: Sulaiman Sulaiman , Gunawan April 
Published: December 2024

Wind tunnel (Terowongan) angin adalah peralatan uji berstruktur tabung dimana udara dipaksa melaju dengan sangat kencang yang mana untuk mempelajari efek aliranaerodinamis pada suatu objek benda, untuk melakukan pengujian menggunakan blade yang mana angin yang dipakai dengan kecepatan 3,4,5 dan 6 m/s. jenis blade dengan bahan kayu pinus, dengan Naca 4412, blade Naca 4412 dengan bahan resin epoxsy 70% + fiber glass 30%, blade Naca 4412 dengan bahan resin epoxsy 70% + fiber gllas 18% + serabut kelapa 12%, blade Naca 4712 dengan bahan resin epoxsy 70% + fiber glass 18% + serabut kelapa 12% dan blade Naca 5513 dengan bahan resin epoxsy 70% + fiber glass 18% + serabut kelapa 12%, Jenis Blade resin epoksi + fiber glass + coir Naca 4412 blade yang paling tinggi putarannya dibandingkan jenis blade yang lainnya yang telah di uji,dimana putaran generator pada kecepatan angin 3 m/s putaran generaotor yang telah di hitung rata-rata nya mencapai 545.29 Rpm, kecepatan angin 4 m/s putaran generator 708.9 Rpm, pada kecepatan angin 5 m/s putaran generator 928.94 Rpm, dan pada kecepatan angin 6 m/s putaran generator 928.94 Rpm.
PENGARUH LUBANG DAN JUMLAH DISK TERHADAP PERFORMA TURBIN TESLA
Authors: Marfizal Marfizal , Wardianto Dedi , Sufiyanto Sufiyanto 
Published: December 2024

Penelitian ini fokus pada Pengaruh lobang dan jumlah disk terhadap performa turbin tesla, dimana eksperimen ini menggunakan satu unit turbin tesla dengan debit aliran masuk konstan 0,037 m3/s dan pembebanan konstan 50 kg pada. Kemudian dilakukan pengujian dengan memvariasikan jumlah lobang pada disk ( 4, 6, 8) dan memvariasikan jumlah disk ( 11,13, 15) dengan diameter lobang 10 mm, diameter disk 160 mm, tebal disk 0.5 mm. setelah dilakukan pengujian dan Analisa data terlihat bahwa variasi faktor jumlah lobang pada disk (4,6,8) dan faktor jumlah disk dapat disimpulkan bahwa daya maksimum 310,148 Watt untuk faktor jumlah lobang pada disk sedangkan untuk faktor jumlah disk sebesar 301,154 Watt, dimana terdapat selisih sebesar 8,994 Watt. Sedangkan untuk effisiensi maksimum 73,754 untuk faktor jumlah lobang pada disk sedangkan untuk faktor jumlah disk sebesar 71,652, dimana terdapat selisih sebesar 2,102.
A New Load Rating Criterion Avoids Overdesigning Downhole Tools
Authors: Zhong Allan , Gar Shobeir Pirayeh 
Published: December 2024

Summary
The traditional approach to designing completion tools can result in the inefficient use of materials and/or inaccurate or overly conservative load ratings for some applications. In this paper, we present a new load-rating criterion, the onset of global nonlinearity, which can more accurately represent the actual strength of downhole tools in those scenarios. Using the onset of global nonlinearity may allow for higher load and pressure ratings for a component than would be produced by traditional design approaches. This new load-rating criterion has been demonstrated through the first principal analysis, laboratory experiments, and field results in applications such as hydraulic fracturing, sand control tools, subsurface safety valves, and injector-producer cycles. The increased load and pressure ratings are most striking in high-pressure and high-temperature applications.
The prevailing load rating criteria for metallic tools are based on material yield strength. The initial yield criterion using von Mises stress, which dictates the load limit that a downhole tool can carry before exhibiting plastic deformation, is often used to design completion tools. However, for some applications of downhole tools, this load rating criterion can be overly conservative, limiting the design options unnecessarily. Several load rating criteria are evaluated and discussed considering the fundamentals of engineering mechanics. Based on our investigation, we propose a mechanics-based load rating criterion for applications where the number of peak load cycles is small and where small-scale yielding is allowed to occur in a localized area without causing major nonlinearity in the global scale. The load rating criterion is termed the onset of global nonlinearity.
Engineering mechanics for several widely used load rating criteria are discussed and their application ranges and limitations, if any, are identified. The proposed onset of global nonlinearity for applications with low numbers of peak load cycles was validated through experimental tests under burst and collapse pressures as well as tensile and torque loads. The global onset of nonlinearity has been successfully applied for applicable downhole tools in real projects.
A new load rating criterion for applications with low cycles of peak loading helps to use the load-carrying capacity of the material fully and safely. Applying the onset of nonlinearity approach typically yields a higher load rating, which may be as much as 1.5–2 times more than that defined by the initial yield criterion, when the tools operate in noncorrosive environments, the required peak load cycle number is small (e.g., less than 200), and the tool materials are ductile.
Galactose impairs motor performance and cerebellar signaling in young male Wistar rats
Authors: Ferreira Bruna Klippel , Paz-Simoes Thiago , Melo Thairine Neves , Gonçalves Patricia Felix Rolo , Kubrusly Regina Celia Cussa , Reis Ricardo Augusto de Melo , Neves Gilda Angela , Ferreira Gustavo Costa , Schuck Patricia Fernanda 
Published: December 2024

Abstract

Galactosemias are a group of inborn errors of galactose metabolism that causes different motor symptoms such as ataxia, tremor, and fine motor dysfunction. The objective was to investigate the cerebellar damage caused by an acute galactose administration. Thirty-day-old male and female Wistar rats were used. Animals were randomized into the following groups: I) galactose group, receiving a single subcutaneous administration of galactose; II) control group, receiving the vehicle solution under the same conditions. One, 3 or 24 h after administration, the animals were evaluated in the rotarod test. A lower motor performance was observed in male rats 3 hours after a galactose administration. This effect was not seen in females or with galactose exposure for 1 or 24 hours. The activities of acetylcholinesterase and choline acetyltransferase were found unaltered in the cerebellum of males 3 h after galactose injection. We also found lower TH levels in cerebellar hemispheres and higher TH levels in cerebellar vermis 3 h after galactose administration in male rats, without differences in MAO-A or MAO-B activities. Galactose administration resulted in lower p-CREB(Ser133) levels in cerebellar hemispheres, without altering p-CREB(Ser133) levels in cerebellar vermis of male rats. Finally, a decrease in TrkB-FL immunocontent (but not of TrkB-T levels) was observed in male cerebellar hemispheres. The signs and symptoms of galactosemic patients underscore the need to study galactose effects in males and females and in various brain areas. Our findings enhance the understanding of therapeutic mechanisms of catecholaminergic drugs, which are proposed as a potential therapy for galactosemia.
Unravelling Physical and Radiobiological Effects of Proton Boron Fusion Reaction with anionic Metallacarboranes ([o-COSAN]-) in Breast Cancer Cells
Authors: Belchior Ana , Alves Bianca C. , Mendes Edgar , Megre Francisco , Alves Luís C. , Santos Pedro , Nishimura Kai , Nakamura Hiroyuki , Teixidor Francesc , Viñas Clara , Sampaio Jorge Miguel , Marques Fernanda , Pinheiro Teresa 
Published: December 2024

Abstract

Background: Protons, which are considered low-LET (Linear Energy Transfer) radiation, have an average RBE (relative biological effectiveness) of 1.1, with a range from 0.7 to 1.6. Thus, increasing biological effectiveness is of high interest in radiation oncology, and one way to enhance this is by using radiosensitizers. The present work investigates the effectiveness of the proton boron fusion reaction (PBFR) at the cellular level, using the sodium salt of metallacarborane [3,3’-Co(C2B9H11)2]- (Na[o-COSAN]) as the boron source, aiming to explore the potential of this type of boron clusters as a radiosensitizer for proton therapy. Therefore, the main goal was to test the hypothesis that loading the cells with boron will favour the PBFR at energies close to the Bragg peak. This would enhance the radiation-induced biological effects through the production of alpha-particles.
Results: As expected, we observed higher biological damage in irradiated cells and the presence of [o-COSAN]- potentiated the damage. These results translate into a lower cellular viability, indicating that DNA damage imposed colonies smaller than their non-irradiated counterparts. This suggests that these damages either took longer time to be repaired or made the cells undergo less efficient survival mechanisms.
Conclusions: The radiosensitizing effect of [o-COSAN]- by strategic cellular 11B placement and proton irradiation intensifies the DNA damage, making the nucleus particularly susceptible and thus increasing the destructive capability of alpha-particles, generated in the nuclear fusion reaction, which may lead to increased cell mortality.
Evaluating Physician Concordance in Interpretation of Tracheobronchomalacia Diagnosis and Phenotyping Using Dynamic Expiratory Chest Computed Tomography
Authors: Cortes-Puentes Gustavo A. , Matatko Martin , Bartholmai Brian J. , Edell Eric S. , Lim Kaiser G. 
Published: December 2024

Abstract

Background: Tracheobronchomalacia (TBM) presents diagnostic challenges due to its nonspecific symptoms and variability in diagnostic methods. This study evaluates physician concordance in TBM diagnosis and phenotyping using chest computed tomography (CT) scans with dynamic expiratory views.
Methods: We conducted a retrospective cross-sectional study at Mayo Clinic Rochester, analyzing 150 patients with dynamic expiratory CT scans. Three specialists—a thoracic radiologist, a bronchoscopist, and a pulmonologist—reviewed identical CT scans, blinded to prior interpretations. Inter-rater agreement was assessed using Fleiss's Kappa for TBM diagnosis and Cohen's Kappa for TBM phenotype classification into six categories: No TBM, Excessive Dynamic Airway Collapse (EDAC), Crescent Type, Circumferential Type, Saber-Sheath Type, and Mixed Type.
Results: Among the 150 patients, 54 (36%) were diagnosed with TBM or EDAC. TBM was more prevalent in males, older individuals, and smokers. Agreement among specialists was substantial for TBM diagnosis (Fleiss’s Kappa = 0.61, p < 0.001) but moderate for phenotype classification (Fleiss’s Kappa = 0.52, p < 0.001). The highest concordance was between the thoracic radiologist and the pulmonologist (Cohen's Kappa = 0.68), while the lowest was between the bronchoscopist and other specialists.
Conclusion: There is substantial agreement in TBM diagnosis using chest CT scans with dynamic expiratory views, but moderate variability in phenotyping. Standardizing criteria and integrating pulmonary function testing could enhance diagnostic consistency and clinical relevance.