bluuebunny/crossref_metadata_2025_split huggingface dataset:
The characterization and frequency of diagnosis of EBV-positive variants with a lymphoid predominance in the structure of Hodgkin lymphoma
Authors: Shupletsova I. A. , Kovrigina A. M. 
Published: December 2021

Introduction. Epstein — Barr virus (EBV) plays an important role in the pathogenesis of lymphoid tumors, in particular Hodgkin lymphoma. The frequency of expression of the EBV varies in different histological variants of classical Hodgkin lymphoma and is rarely observed in nodular lymphocyte predominant Hodgkin lymphoma.Aim — to study the pathomorphological features of the histological variants of Hodgkin lymphoma with lymphoid predominance associated with the EBV, as well as the frequency of their diagnosis in the structure of Hodgkin lymphoma.Materials and methods. The retrospective study included 794 patients with a verified diagnosis of Hodgkin lymphoma using histological and immunohistochemical methods on biopsy material for the period 2018–2019 (age range — 18–91 years old; median — 34 years old; men : women — 1.1 : 1). The presence of EBV in biopsies was assessed by immunohistochemical reaction with antibodies to EBV (clone LMP1), or by chromogenic in situ hybridization with probes for EBV-encoded small RNAs.Results. Classical Hodgkin lymphoma was diagnosed in 91 % (725/794) cases, nodular lymphocyte predominant Hodgkin lymphoma — in 9 % (69/794) cases. EBV-positive Hodgkin lymphoma accounted for 11 % (82/725) of all cases of classical Hodgkin lymphoma, (age range — 18–81 years old, median — 45 years old; men : women — 2.5 : 1). All cases of nodular lymphocyte predominant Hodgkin lymphoma were EBV-negative. Lymphocyte-rich classical Hodgkin lymphoma was found in 14 patients (14/725, 2 %), 4 patients showed intermediate morphoimmunohistochemical features with nodular lymphocyte predominant Hodgkin lymphoma, which were statistically significantly different from classical Hodgkin lymphoma by the presence of B-zones in the form of large nodules (p = 0.0157) and expression CD20 by tumor cells (p = 0.0404).Conclusion. Nodular lymphocyte predominant Hodgkin lymphoma is not characterized by a connection with EBV infection, unlike classical variant — lymphocyte-rich classical Hodgkin lymphoma. The obtained data support the concept of the existence of a transient form of Hodgkin lymphoma, which has the features of nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma, in the pathogenesis of which the Epstein — Barr virus likely plays a role.
Clonal hematopoiesis and its role in the development of hematological diseases
Authors: Petinati N. A. , Drize N. J. 
Published: December 2021

Introduction. The formation of blood cells in a healthy individual is ensured by polyclonal hematopoiesis. Recent studies have shown that with age, large clones with a common genetic marker are found in the peripheral blood, i. e. cells originating from a single progenitor cell. This phenomenon is called clonal hematopoiesis. In some cases, people with clonal hematopoiesis develop hematological diseases.Aim — to describe and summarize current data on the relationship between clonal hematopoiesis and hematological diseases.Main findings. This review describes the history of detection of clonal hematopoiesis, its main properties, the most frequent mutations in hematopoietic clones associated with the risk of transformation into myelodysplastic syndrome, and acute myeloid leukemia. The meaning and possible pathogenesis of tumor transformation are discussed.
Thermolability of factor VIII in donor fresh frozen blood plasma
Authors: Lemondzhava V. N. , Chechetkin A. V. , Gudkov A. G. , Leushin V. Yu. , Kasianov A. D. , Kiseleva E. A. 
Published: December 2021

A criterion of the quality of fresh frozen blood plasma (FFP) is the activity of clotting factor VIII (FVIII).Aim — to identify technological barriers in the study of FVIII thermolability and to describe the requirements for experiments, providing new knowledge about the thermolability of this factor.Basic information. An analysis of domestic and foreign publications devoted to the study of the mechanisms responsible for reducing the value of FVIII activity in donor blood plasma from the moment of donation to the moment of transfusion was carried out. Data on the decrease in FVIII activity at various stages of work with blood plasma are presented. An analysis of methods for preparing samples for studying changes in the values of FVIII in donor blood plasma was performed. The existence of contradictory conclusions about the infl uence on the change in FVIII at the thawing stage of various values of the effects on FFP and poor knowledge of the change in the indicator at the stage of heating to the transfusion temperature after the end of the phase transition in the samples was established. The fundamental differences in the methods of preparing and conducting experiments in previous works are determined. Methods for increasing the reliability of experimental results for studying the thermal lability of FVIII are proposed.
Green Energy in the Caribbean: Influence on Toursim and Economic Development
Authors: Tazikhina Tatiana , Kvasha Vladimir , Solovova Yulia , Guliev Igbal 
Published: December 2021

The green energy agenda has become one of the most important issues in international relations. Many island states of the Oceania have taken the course of green economy construction. The Caribbean states are in some way similar to the Oceania ones and have also made several steps towards greener future. Some of these states are tightly connected with international tourism, leading to the high dependence of their economies from touristic revenues. The article examines this interconnection, including economic component in the analysis. The major question of the article is how does (or doesn’t) tourism influence the development of green energy in the Caribbean states. The two major economies examined in the region are Cuba and Dominican Republic as the two examples of the totally different economic systems and approaches to the development of the green energy. The key findings of the article include such conclusions as the possibility of synergetic interdependence between tourism, economy and green energy and the positive effects this interdependence has. The other finding is that the Cuban method of introducing green energy is less effective than the Dominican one. The novelty of the article includes the comparison of the two economic models in the Caribbean and the development of strategies for the green energy proliferation in the countries.
Samkhya Philosophy, Deep Ecology and Sustainable Development
Authors: Biswas Nanda Gopal , Prakash Gyan 
Published: December 2021

Samkhya philosophy is one of the oldest philosophies in the Indian philosophical system. This philosophy is independent in origin and mainly known for its evolution theory. Samkhya philosophy has accepted the two ultimate and independent realities, Nature and pure Consciousness. This paper is an attempt to comprehend the notion of deep ecology from the Samkhya’s evolution theory perspective. In this paper, firstly, we have elucidated the Samkhya philosophy of suffering and the solution to the problem. In the second part of the article, we have argued that how Samkhya’s philosophical notion of Nature demonstrates our embeddedness in Nature. Therefore, the idea of deep ecology is always there in one or another form in Samkhya philosophy. It has also connections to the idea of sustainable development.
Observation of frequency dependent resonances in magnetic vortex core gyration using time-resolved magneto-optical Kerr microscope with pulsed semiconductor laser illumination
Authors: Ogasawara Takeshi , Yamaguchi Akinobu 
Published: December 2021

Abstract
Frequency dependent resonance of magnetic vortex core gyration in micrometer sized permalloy squares was observed by time-resolved magneto-optical Kerr microscope using pulsed semiconductor lasers as a light source in the stroboscopic method. Uniform and efficient laser illumination was realized by a speckle reducer consisting of an oscillating multimode optical fiber and a microbending mode scrambler. The resonance frequency of the same sized permalloy squares showed a non-uniformity of up to 15%, suggesting the flatness of the underlayer has a strong influence on the gyration motion.
Formulation of trade-off relationships between resolution, line edge roughness, and sensitivity in sub-10 nm half-pitch region for chemically amplified extreme ultraviolet resists
Authors: Kozawa Takahiro 
Published: December 2021

Abstract
The manufacturing of semiconductor devices using extreme ultraviolet (EUV) lithography started in 2019. A high numerical aperture tool under development is capable of resolving 8 nm line-and-space optical images and will extend the application of EUV lithography. However, resist materials have not been yet applicable to the production with 8 nm resolution. In this study, the relationships among the half-pitch of line-and-space patterns (resolution), chemical gradient [an indicator of line edge roughness (LER)], and sensitivity were investigated in the sub-10 nm half-pitch region for chemically amplified EUV resists. The chemical gradient was simulated on the basis of their sensitization and reaction mechanisms. The relationship was formulated as a function of total sensitizer concentration (the sum of photoacid generator and photodecomposable quencher concentrations) and the thermalization distance of secondary electrons. The effect of thermalized electrons was well incorporated into the trade-off relationships between resolution, LER, and sensitivity. (147/150)
The interferometric measurement of thermal lens effect in an LD pumped Tm-doped bulk laser
Authors: Zhao Yuantao , Zhao Shengzhi , Li Tao , Liu Yizhou , Wang Chun , Zhao Yuefeng , Song Yuzhi , Hu Ping , Mao Jiajia , Yang Kejian , Zhang Lu , Feng Tianli 
Published: December 2021

Abstract
Directly measuring thermal focal length is important for designing and optimizing the mode-locking oscillator, especially for a 2 μm mode-locking laser. In this paper, we propose a novel interferometric method for measuring the thermal focal length in a 2 μm mode-locking laser. This method provides a precise measurement of the thermal focal length inside a long-folded oscillator in both lasing and non-lasing operation. We also theoretically calculate the thermal focal length based on the temperature distribution inside the laser crystal, which matches well with the experimental results.
Analisis Kemampuan Kerjasama Dalam Perilaku Sosial Anak Usia Dini
Authors: Ramelan Harlina , Suryana Dadan 
Published: December 2021

Perilaku sosial merupakan salah satu bagian dalam aspek perkembangan sosial anak usia dini. Perilaku sosial harus ditumbuhkan semenjak anak masih usia dini. Keterlambatan perkembangan sosial anak dapat menghambat anak untuk mengembangkan dirinya dimasa depan. Tidak seluruh anak bisa memperlihatkan perilaku sosial yang diharapkan. Salah satu contoh perilaku sosial yang terjadi adalah kurangnya kerjasama anak dengan orang lain. Penelitian ini bertujuan untuk mendeskripsikan kemampuan kerjasama yang dimunculkan oleh anak usia dini. Metode yang digunakan dalam penelitian ini adalah metode penelitian deskriptif kualitatif dengan studi literatur. Dalam penelitian studi literatur ini peneliti melakukan pengumpulan data dengan mengumpulkan dan menganalisis berbagai sumber tertulis seperti artikel, jurnal, dan buku yang relevan dengan penelitian ini. Kurangnya kemampuan kerjasama anak dengan orang lain baik dalam melakukan kegiatan maupun kerjasama dalam bermain akan mempengaruhi proses sosialisasi anak. Oleh karena itulah dibutuhkan peran orang tua, pendidik, lingkungan sekitar dan teman sebaya dalam mengembangkan perilaku sosial anak terutama kerjasama anak dengan orang lain.
ANALISIS PERFORMA MESIN CAMSHAFT STANDART DAN CAMSHAFT MODIFIKASI SEPEDA MOTOR 110CC
Authors: Gufron Moch , Wahyudi Djoko , Dwi K.D Indah Noor 
Published: December 2021

Saat ini sepeda motor merupakan alat transportasi yang paling banyak digunakan di Indonesia. Selain sebagai alat transportasi dan untuk pengantar barang tentu saja memiliki settingan yang berbeda dengan sepeda motor yang digunakan untuk keperluan sehari-hari dengan melakukan perbaikan performa dengan cara memodifikasi noken as (camshaft) pada motor yang digunakan sehari-hari. Fungsi dari camshaft adalah untuk mengontrol bukaan katup, baik katup hisap maupun katup buang pada waktu yang telah ditentukan oleh siklus mesin empat langkah. Pada motor mesin modifikasi telah dilakukan modifikasi pada beberapa sistem dan komponennya untuk meningkatkan performa sepeda motor tersebut.Tujuan dari penelitian ini adalah untuk mengetahui unjuk kerja motor bakar Honda Absolute revo 110 cc yang meliputi torsi, daya dan konsumsi bahan bakar dengan cara membandingkan camshaft standar dan camshaft modifikasi yang telah dirubah tinggi liftnya 1mm mengalami perubahan pada mesin absolute revo 110cc perubahan terjadi di antaranya pada torsi ,daya dan konsumsi bahan bakar lebih banyak masuk ke dalam ruang bakar Penelitian tersebut di peroleh dari alat yang bisa menentukan daya nama alatnya Dynotest, alat tersebut berfungsi untuk mengukur daya tosi sepeda motor yang telah di modifikasi camsafth agar tau lebih baik mana camasafth modifikasi dan camsafth standart pada sepeda motor revo absolute 110cc.
Nonperiodic Type I Be/X-Ray Binary Outbursts
Authors: Martin Rebecca G. , Franchini Alessia 
Published: December 2021

Abstract
Type I Be/X-ray binary outbursts are driven by mass transfer from a Be star decretion disk to a neutron star companion during each orbital period. Treiber et al. recently observed nonperiodic type I outbursts in RX J0529.8–6556 that has unknown binary orbital properties. We show that nonperiodic type I outbursts may be temporarily driven in a low eccentricity binary with a disk that is inclined sufficiently to be mildly unstable to Kozai–Lidov oscillations. The inclined disk becomes eccentric and material is transferred to the neutron star at up to three locations in each orbit: when the neutron star passes the disk apastron or one of the two nodes of the disk. The timing and magnitude of each vary with the disk argument of periapsis and longitude of the ascending node that precess in opposite directions. Calculating the orbital period of the RX J0529.8–6556 system is nontrivial but we suggest it may be >300 days, longer than previous estimates.
Effect of Silver Diamine Fluoride Pretreatment on Shear Bond Strength of Resin Modified Glass Ionomer Cement to Primary Dentin
Authors: Sa’ada Maiada Mohammad Ahmad , Khattab Nagwa Mohammed Ali , Amer Maha Ishaq 
Published: December 2021

AIM: The aim of the study was to evaluate effect of silver diamine fluoride (SDF) on the shear bond strength (SBS) of glass ionomer restoration to primary dentine. MATERIALS AND METHODS: Twenty extracted primary molars with no restorations or developmental anomalies were only chosen for the study. Twenty dentine slices with 2 mm thickness were prepared and then randomly allocated into two groups (n = 10 per group). For Group 1 (experimental): Dentine surfaces were treated with 38% *SDF solution (Elevate oral care, USA) for 3 min using micro-brush, followed by a 30 s rinse with water and Group 2 (Control): Dentine surfaces were treated with distilled water for 3 min then rinsed for 30 s. The cavity conditioner was applied to flat dentin of both groups for 10 s then washed and dried gently with compressed air. All the specimens were restored with *RMGIC (Riva Light Cure, SDI, Australia). SBS was determined using a Universal Testing machine and Failure mode was evaluated using stereomicroscope. Data were collected and statistically analyzed. Independent t test was used to assess differences in SBS between study groups and mode of failure was analyzed using Fisher’s exact test. Level of significance was set at p ≤ 0.05. IBM SPSS statistical software (version 26) was used to analyze the data. RESULTS: The experimental group had significantly higher mean of shear bond (11.92 ± 3.35) strength than the control group (6.99 ± 2.98) (p = 0.003). CONCLUSIONS: Primary dentin pre-treatment with 38% SDF increases the shear bond strength between RMGIC and primary dentin according to the results of this in vitro study.
Barriers in Diabetes Self-management: A Qualitative Study from the Perspective of Nurses in Primary Health Centers, Indonesia
Authors: Isworo Atyanti , Sari Yunita , Sumeru Annas , Nuriya Nuriya 
Published: December 2021

BACKGROUND: Nurses play an essential role, including being the main educator of diabetes mellitus (DM). It is necessary to reduce the barriers faced by nurses in managing patients’ self-management.

AIM: The purpose of this study was to explore the barriers faced by nurses in managing the self-management of DM patients.

METHODS: This research is a qualitative-research with a phenomenological approach. The recruitment of participants used a purposive sampling method, which was divided into two Focus Group Discussion (FGD) groups: the first group consisted of five nurses from the urban health center and the second group consisted of five nurses from the suburban area. The FGD was conducted twice for each group: 90 min for the first and 45 min for the second. The data were analyzed using Colaizzi’s method of data analysis.

RESULTS: This study resulted in two themes, namely, internal barriers within the patient and external barriers outside the patient. The barriers from within the patient theme had five subthemes including (1) fear of being exposed to the disease and stigma associated with diabetes, (2) fear and distrust of health cadres, (3) low self-awareness and feeling healthy so not seeking treatment, (4) lack of responsibility for diabetes self-management practices, and (5) time issues. The second theme of barriers external to the patients included three subthemes that were (1) limited manpower, (2) limited facilities and funds, and (3) a lot of programs or activities.

CONCLUSION: Nurses faced external barriers that arise from the puskesmas and internal barriers within the patient.
Être mère d’un·e adolescent·e suivi·e pour un cancer : un travail de care genré et socialement différencié
Authors: Rollin Zoé , Sivilotti Lucas 
Published: December 2021

À partir de deux terrains de recherche socio-ethnographiques menés auprès d’adolescent·e·s et jeunes adultes ainsi que leurs parents, cet article cherche à investiguer en quoi le contexte de l’irruption d’un évènement grave de santé comme le cancer vient modifier le travail des mères. À partir d’une approche interactionniste, cet article étudie la « gestion sociale de la maladie » (Strauss, 1992) d’un point de vue sociologique, en ajustant la focale sur le versant scolaire de celle-ci en tant que point d’observation heuristique pour saisir certaines dimensions du travail des mères. Le propos principal de cet article est de mettre en évidence le travail des mères d’adolescentes et d’adolescents, dont le quotidien est particulièrement impacté par la survenue de la maladie grave.
La péridurale, un non-choix ? Ethnographie des formes de résistance à une innovation « miracle »
Authors: Quagliariello Chiara , Topçu Sezin 
Published: December 2021

En France où l’anesthésie péridurale est très généralisée, une proportion non négligeable de femmes ne souhaitant pas en bénéficier a priori finissent par y recourir. À partir d’un travail ethnographique mené dans une maternité publique de niveau 3 située dans la petite couronne parisienne, cet article se focalise tout d’abord sur les causes des réticences et des refus exprimés par certaines catégories de femmes vis-à-vis de la péridurale. Ensuite, nous examinons les différentes stratégies d’évitement ou de contournement de l’anesthésie péridurale à deux moments-clés du contact des femmes avec le corps médical : les consultations anesthésiques au huitième mois de grossesse et les interactions avec les professionnel·le·s de santé en salle de travail. Enfin, à travers l’étude des stratégies mises en œuvre par les femmes, il s’agit de décrypter les diverses épreuves que les femmes doivent surmonter pour faire valoir leurs choix et intervenir sur leur parcours d’accouchement à l’hôpital.
Le demandeur d’asile bénévole, nouvelle figure du « migrant méritant » ?
Authors: Di Cecco Simone 
Published: December 2021

À partir de l’analyse des programmes de bénévolat pour demandeur·euse·s d’asile en Italie, cet article s’attache à étudier l’émergence d’une nouvelle figure du « migrant méritant » : le migrant bénévole, reconnaissant et actif, disposé à effectuer gratuitement des activités dites d’intérêt général. Dans le contexte italien, la participation aux programmes de bénévolat s’affirme comme un gage de mérite exigé à certaines populations étrangères, notamment celles gouvernées par les politiques d’asile et insérées dans le système des centres d’hébergement, qui doivent alors faire preuve non seulement de vulnérabilité, mais aussi d’intégration et d’engagement civique. Des écarts et des marges de manœuvre existent néanmoins entre le spectacle de l’intégration et de la valeur civique véhiculé par les programmes de bénévolat, et les pratiques concrètes des demandeur·euse·s d’asile bénévoles. L’étude des tactiques de réappropriation, de mise à distance et de contournement des activités non rémunérées révèle que l’émergence de cette figure de migrant méritant, tout en ayant des effets de mise en concurrence et de distinction entre les demandeur·euse·s d’asile, n’est pas à l’abri de formes plus ou moins visibles de critique et de contestation.
Assessment of Intrapelvic Blood Flow with the Penile Brachial Index Using a Toe Blood Pressure Cuff in Japanese Patients with Lower Urinary Tract Symptoms
Authors: Hayashi Keiichiro , Sasaki Haruaki , Fuji Kohzo , Hiramatsu Aya , Yamagishi Motoki , Matsumoto Yuki , Matsubara Eiji , Saito Katsuyuki , Ishikawa Kimiyasu , Fukagai Takashi , Ogawa Yoshio 
Published: December 2021

Purpose:
We aim at investigating the relationship between lower urinary tract symptoms (LUTSs) and intrapelvic blood flow. Conventionally, intrapelvic blood flow is assessed using a Doppler blood flowmeter. In this study, the penile brachial pressure index (PBI), which is a simpler tool, was used.

Materials and Methods:
The participants of this study were 103 male outpatients with LUTS whose PBI was measured using the form pulse wave velocity/ankle-brachial index with a toe blood pressure cuff. Data including age, body mass index (BMI), penile blood pressure, PBI, complications (hypertension, dyslipidemia, and diabetes mellitus), International Prostate Symptom Score (IPSS), and Erection Hardness Score (EHS) were retrospectively examined. LUTS positivity was defined as an IPSS score ≥8 and LUTS negativity as an IPSS score <8.

Results:
The PBI and EHS scores were significantly higher in the LUTS-negative participants than in the LUTS-positive participants. Furthermore, a multivariate analysis showed a significant difference only in PBI. However, age, BMI, EHS, or previous history of complications did not significantly differ.

Conclusion:
PBI was found to be an independent factor of LUTS. Recent studies have shown that LUTS and erectile dysfunction are associated with lifestyle-related diseases, and that these conditions are caused due to impaired blood flow in the intrapelvic arteries due to arteriosclerosis. Therefore, LUTS should be treated as a vascular disease.