bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial variation in provenance signal: identifying complex sand sourcing within a Carboniferous basin using multiproxy provenance analysis
Authors: Anders B. , Tyrrell S. , Chew D. , Mark C. , O'Sullivan G. , Murray J. , Graham J.R. , Badenszki E. 
Published: August 2021

Multiple factors (e.g. source rock composition, climate, nature/scale of sedimentary system) influence the volume and composition of sediment delivered to basins. Fluctuations in these parameters produce cryptic source signals which can vary within the same sedimentary system. Bespoke multi-proxy provenance approaches, targeted at minerals of variable stability, allow for an assessment of natural biasing (recycling) and intra-basinal spatial variations.
Provenance of fluvial/deltaic sandstones (Mullaghmore Sandstone Formation) in the NW Carboniferous Basin, Ireland, has been constrained using zircon and apatite U–Pb geochronology, trace elements in apatite and Pb-in-K-feldspar analysis. Zircon U–Pb grain populations are consistent with feldspar data, suggesting Proterozoic basement highs offshore Ireland and Scotland were the main contributor with minor supply from Archean–Paleoproterozoic rocks of Greenland/NW Scotland and Caledonian-aged rocks. However, apatite data show a much larger proportion of Caledonian-aged grains of metamorphic origin, suggesting significant sediment was recycled from Neopropterozoic metasedimentary rocks. The spatial variation in provenance indicates that, at onset of clastic input, sediment was being routed to the basin through a complex drainage system, comprising several discrete hinterland catchments, rather than supply from a single, large interconnected sedimentary system. Such complexities can only be identified with the careful application of a bespoke multi-proxy provenance approach.

Supplementary material:
Tables 1-5 and individual Pb-in-K feldspar plots are available at
https://doi.org/10.6084/m9.figshare.c.5536691
5-Aminosalicylic Acid Prevents Disease Behavior Progression and Intestinal Resection in Colonic and Ileocolonic Crohn’s Disease Patients: A Retrospective Study
Authors: Wan Jian , Wang Xuan , Zhang Yujie , Xue Xianmin , Li Yani , Liu Zhenzhen , Han Shuang , Chen Min , Nie Yan , Shi Yongquan , Liang Jie , Wu Kaichun 
Published: August 2021

Background and Aims. The efficacy of 5-aminosalicylic acid (5-ASA) in the long-term outcome of Crohn’s disease (CD) patients was uncertain. This study aimed to evaluate the efficacy of the 5-ASA in preventing disease behavior progression and intestinal resection in CD patients. Methods. CD patients were prospectively enrolled from January 2008 to September 2019 in Xijing Hospital. Disease behavior progression was defined as the development of stricturing (B2) or penetrating disease (B3) in patients with nonstricturing/nonpenetrating disease (B1) at diagnosis. Cox regression analyses were used to investigate the associations between disease location progression, disease behavior progression, and intestinal resection and multiple covariates. Results. In total, 122 CD patients were followed up for 4.3 years. At the time of diagnosis, disease location was ileal in 19.7% (24/122), colonic in 41.0% (50/122), and ileocolonic in 39.3% (48/122). A total of 87 (71.3%) patients had B1 at diagnosis. The disease behavior progression and intestinal resection rates were 42.5% (37/87) and 29.5% (36/122). The use of 5-ASA reduced the risk of disease behavior progression (HR 0.30, 95% CI 0.14–0.61,

P

= 0.001) and intestinal resection (HR 0.33, 95% CI 0.17–0.90,

P

= 0.027) in colonic and ileocolonic CD patients. Patients who presented with ileal disease at diagnosis did not have the same protective effects when taking 5-ASA (

P

> 0.05). Conclusions. The use of 5-ASA could improve the long-term outcome of CD patients with colon involvement. The result emphasized the importance of early use of 5-ASA in the daily management of colonic involved CD.
The Hydroethanolic Stem Bark Extract of Tieghemella heckelii (A.Chev.) Pierre ex Dubard (Sapotaceae) Produced N-Methyl-D-Aspartate (NMDA) Receptor-Dependent Analgesia and Attenuates Acute Inflammatory Pain via Disruption of Oxidative Stress
Authors: Kumatia Emmanuel K. , Appiah-Opong Regina 
Published: August 2021

Background. Tieghemella heckelii stem bark is used in African traditional medicine to treat inflammatory pain conditions. However, these biological actions of the plant have not been proven. This study investigates the phytochemical composition and the mechanisms of analgesic and anti-inflammatory actions of the hydroethanolic stem bark extract of T. heckelii (THBE). Methods. Phytochemical composition of THBE was investigated using qualitative and quantitative phytochemical analyses. Anti-inflammatory activity was evaluated using the carrageenan-induced paw oedema assay. Analgesic activity was evaluated using hot plate and acetic acid-induced writhing assays. Mechanism of analgesic action was determined using pharmacological antagonist such as naloxone, atropine, flumazenil, nifedipine, or ketamine. Test agents were administered orally as follows: Tween 80 (5%) (control), diclofenac sodium (DS) 10/tramadol 9 mg/kg (standard), or THBE 10, 100, and 450 mg/kg. Glutathione peroxidase (GPx), superoxide dismutase (SOD), and lipid peroxidation levels were also measured. Results. THBE which contained 58.45% saponins, 229.04 ± 0.049 GAE mg/g phenolic compounds,and 0.482 ± 0.0028 QE mg/g flavonoids produced (

p

< 0.5) anti-inflammatory effect of 56.22% and analgesia of 330 ± 72% and 50.4% in the hot plate and writhing assays, respectively, at 10 mg/kg and inhibited oxidative stress by GPx and SOD elevation in rats during inflammation. Ketamine significantly blocked the analgesia of THBE, indicating NMDA receptor-dependent analgesic action. Whereas, naloxone, atropine, nifedipine, and flumazenil could not antagonize the analgesic action of THBE. Conclusion. These results show that THBE produced potent anti-inflammatory effect via disruption of oxidative stress and also generated NMDA receptor-dependent analgesia.
Prognostic Utility of Breast Cancer Index to Stratify Distant Recurrence Risk in Invasive Lobular Carcinoma
Authors: Nunes Raquel , Sella Tal , Treuner Kai , Atkinson Jennifer M. , Wong Jenna , Zhang Yi , Exman Pedro , Dabbs David , Richardson Andrea L. , Schnabel Catherine A. , Sgroi Dennis C. , Oesterreich Steffi , Cimino-Mathews Ashley , Metzger Otto 
Published: August 2021

Abstract

Purpose:
The prognostic utility of Breast Cancer Index (BCI) for risk assessment of overall (0–10 years), early (0–5 years), and late (5–10 years) distant recurrence (DR) in hormone receptor–positive (HR+) invasive lobular carcinoma (ILC) was evaluated.

Experimental Design:
BCI gene expression analysis was performed blinded to clinical outcome utilizing tumor specimens from patients with HR+ ILC from a multi-institutional cohort. The primary endpoint was time to DR. Kaplan–Meier analyses of overall, early, and late DR risk were performed, and statistical significance was evaluated by log-rank test and Cox proportional hazards regression. The prognostic contribution of BCI in addition to clinicopathologic factors was evaluated by likelihood ratio analysis.

Results:
Analysis of 307 patients (99% ER+, 53% T1, 42% N+, 70% grade II) showed significant differences in DR over 10 years based on BCI risk categories. BCI low- and intermediate-risk patients demonstrated similar DR rates of 7.6% and 8.0%, respectively, compared with 27.0% for BCI high-risk patients. BCI was a significant independent prognostic factor for overall 10-year DR [HR = 4.09; 95% confidence interval (CI), 2.00–8.34; P = 0.0001] as well as for both early (HR = 8.19; 95% CI, 1.85–36.30; P = 0.0042) and late (HR = 3.04; 95% CI, 1.32–7.00; P = 0.0224) DR. In multivariate analysis, BCI remained the only statistically significant prognostic factor for DR (HR = 3.49; 95% CI, 1.28–9.54; P = 0.0150).

Conclusions:
BCI is an independent prognostic factor for ILC and significantly stratified patients for cumulative risk of 10-year, early, and late DR. BCI added prognostic value beyond clinicopathologic characteristics in this distinct subtype of breast cancer.
Pretreatment Tissue TCR Repertoire Evenness Is Associated with Complete Pathologic Response in Patients with NSCLC Receiving Neoadjuvant Chemoimmunotherapy
Authors: Casarrubios Marta , Cruz-Bermúdez Alberto , Nadal Ernest , Insa Amelia , García Campelo María del Rosario , Lázaro Martín , Dómine Manuel , Majem Margarita , Rodríguez-Abreu Delvys , Martínez-Martí Alex , de Castro-Carpeño Javier , Cobo Manuel , López-Vivanco Guillermo , Del Barco Edel , Bernabé Caro Reyes , Viñolas Nuria , Barneto Aranda Isidoro , Viteri Santiago , Massuti Bartomeu , Barquín Miguel , Laza-Briviesca Raquel , Sierra-Rodero Belén , Parra Edwin R. , Sanchez-Espiridion Beatriz , Rocha Pedro , Kadara Humam , Wistuba Ignacio I. , Romero Atocha , Calvo Virginia , Provencio Mariano 
Published: August 2021

Abstract

Purpose:
Characterization of the T-cell receptor (TCR) repertoire may be a promising source for predictive biomarkers of pathologic response to immunotherapy in locally advanced non–small cell lung cancer (NSCLC).

Experimental Design:
In this study, next-generation TCR sequencing was performed in peripheral blood and tissue samples of 40 patients with NSCLC, before and after neoadjuvant chemoimmunotherapy (NADIM clinical trial, NCT03081689), considering their complete pathologic response (CPR) or non-CPR. Beyond TCR metrics, tissue clones were ranked by their frequency and spatiotemporal evolution of top 1% clones was determined.

Results:
We have found a positive association between an uneven TCR repertoire in tissue samples at diagnosis and CPR at surgery. Moreover, TCR most frequently ranked clones (top 1%) present in diagnostic biopsies occupied greater frequency in the total clonal space of CPR patients, achieving an AUC ROC to identify CPR patients of 0.967 (95% confidence interval, 0.897–1.000; P = 0.001), and improving the results of PD-L1 tumor proportion score (TPS; AUC = 0.767; P = 0.026) or tumor mutational burden (TMB; AUC = 0.550; P = 0.687). Furthermore, tumors with high pretreatment top 1% clonal space showed similar immune cell populations but a higher immune reactive gene expression profile. Finally, the selective expansion of pretreatment tissue top 1% clones in peripheral blood of CPR patients suggests also a peripheral immunosurveillance, which could explain the high survival rate of these patients.

Conclusions:
We have identified two parameters derived from TCR repertoire analysis that could outperform PD-L1 TPS and TMB as predictive biomarkers of CPR after neoadjuvant chemoimmunotherapy, and unraveled possible mechanisms of CPR involving enhanced tumor immunogenicity and peripheral immunosurveillance.
Circulating Tumor DNA Analysis Detects FGFR2 Amplification and Concurrent Genomic Alterations Associated with FGFR Inhibitor Efficacy in Advanced Gastric Cancer
Authors: Jogo Tomoko , Nakamura Yoshiaki , Shitara Kohei , Bando Hideaki , Yasui Hisateru , Esaki Taito , Terazawa Tetsuji , Satoh Taroh , Shinozaki Eiji , Nishina Tomohiro , Sunakawa Yu , Komatsu Yoshito , Hara Hiroki , Oki Eiji , Matsuhashi Nobuhisa , Ohta Takashi , Kato Takeshi , Ohtsubo Koushiro , Kawakami Takeshi , Okano Naohiro , Yamamoto Yoshiyuki , Yamada Takanobu , Tsuji Akihito , Odegaard Justin I. , Taniguchi Hiroya , Doi Toshihiko , Fujii Satoshi , Yoshino Takayuki 
Published: August 2021

Abstract

Purpose:
FGFR2 amplification is associated with poor prognosis in advanced gastric cancer and its subclonal heterogeneity has been revealed. Here, we examined whether circulating tumor DNA (ctDNA) was useful for detecting FGFR2 amplification and co-occurring resistance mechanisms in advanced gastric cancer.

Experimental Design:
We assessed genomic characteristics of FGFR2-amplified advanced gastric cancer in a nationwide ctDNA screening study. We also analyzed FGFR2 amplification status in paired tissue and plasma samples with advanced gastric cancer. In addition, we examined patients with FGFR2-amplified advanced gastric cancer identified by ctDNA sequencing who received FGFR inhibitors.

Results:
FGFR2 amplification was more frequently detected by ctDNA sequencing in 28 (7.7%) of 365 patients with advanced gastric cancer than by tissue analysis alone (2.6%–4.4%). FGFR2 amplification profiling of paired tissue and plasma revealed that FGFR2 amplification was detectable only by ctDNA sequencing in 6 of 44 patients, which was associated with a worse prognosis. Two patients in whom FGFR2 amplification was detected by ctDNA sequencing after tumor progression following previous standard chemotherapies but not by pretreatment tissue analysis had tumor responses to FGFR inhibitors. A third patient with FGFR2 and MET co-amplification in ctDNA showed a limitation of benefit from FGFR inhibition, accompanied by a marked increase in the MET copy number.

Conclusions:
ctDNA sequencing identifies FGFR2 amplification missed by tissue testing in patients with advanced gastric cancer, and these patients may respond to FGFR inhibition. The utility of ctDNA sequencing warrants further evaluation to develop effective therapeutic strategies for patients with FGFR2-amplified advanced gastric cancer.
Strategies for boosting students’ enrolment into business education programme of colleges of education
Authors: Igberaharha Clever Omovigho , Onyesom Moses 
Published: August 2021

<span>A close observation in recent times has shown a steady decline of students’ enrolment into business education programme especially in the colleges of education. The situation is becoming worrisome considering the social implications it has on the education industry. Thus, the study was conducted to determine strategies for boosting students’ enrolment into business education programme of colleges of education in Delta State. Design of this research was descriptive survey and 118 business education lecturers in the colleges of education in Delta State participated in the survey. Data were collected with questionnaire. The results of data analysis showed that the respondents agreed that the attracting and retaining strategies considered in the study were necessary frameworks for boosting students’ enrolment into business education programme. The test of hypotheses showed that irrespective of the years of work experience of the respondents, their responses did not differ significantly. This indicated that the examined attracting and retaining strategies were critical for boosting students’ enrolment. It was concluded that the attracting and retaining strategies determined by the study are effective means of reversing the steady decline of students’ enrolment experienced in recent years at the colleges of education in Delta State, Nigeria.</span>
Long-Term Trajectories of Left Ventricular Ejection Fraction in Patients With Chronic Inflammatory Diseases and Heart Failure: An Analysis of Electronic Health Records
Authors: Rivera Adovich S. , Sinha Arjun , Ahmad Faraz S. , Thorp Edward , Wilcox Jane E. , Lloyd-Jones Donald M. , Feinstein Matthew J. 
Published: August 2021

Background:
Immune regulation and inflammation play a role in the pathogenesis and progression of acute and chronic heart failure (HF). Although the clinical course of acute, severe inflammatory cardiomyopathy is well described, the effects of chronic systemic inflammation on cardiovascular function over time are less clear. To investigate this question, we compared trajectories over time in left ventricular ejection fraction for patients with HF with different chronic inflammatory diseases (CIDs): HIV, systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, inflammatory bowel disease, and/or psoriasis.

Methods:
Using a database of patients receiving care in a large metropolitan health care system since January 1, 2000, we analyzed serial, clinically indicated echocardiograms from patients with HF with CIDs and frequency-matched patients with HF without CIDs. We included patients with ≥3 serial echocardiograms (N=974; median 6.1 years between first and most recent echo). We assessed left ventricular ejection fraction trajectories over time using latent trajectory models, then investigated differences in left ventricular ejection fraction trajectories for specific CID subtypes compared with controls.

Results:
Overall, the majority of patients studied (N=687; 70.5%) had left ventricular ejection fraction trajectories consistent with HF with preserved or midrange EF, whereas 255 (26.2%) had HF with reduced EF and 32 (3.3%) had HF with recovered EF. Compared with non-CID controls with HF, patients with rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus were significantly more likely than controls to have HF with preserved or midrange EF whereas patients with HIV were significantly more likely to have HF with reduced EF.

Conclusions:
Among patients with HF with CIDs, distinct left ventricular ejection fraction trajectory patterns associate with different specific individual CIDs. This highlights the heterogeneity of HF subtypes and changes over time across different CIDs.
A&I, a Suite for Piano, Android Device and Vibration Speaker
Authors: Alunno Marco 
Published: August 2021

Abstract
As part of an ongoing work with speakers that use uncommon technologies to project sound, the author considers here the vibration speaker, a kind of transducer that coaxes a surface to vibrate by direct contact. Presenting pros and cons of vibration speakers, the author illustrates a piano suite that uses an application expressly built for Android as an interface between the sound produced in, on, or with the piano and the speaker: The sound is captured by the Android device, processed by the application, sent via Bluetooth to the speaker sitting on the piano soundboard, and eventually thereby amplified. This relatively simple system allows for a large array of timbral possibilities and unconventional ways of playing the piano.
Beyond Representation in Virtual Reality: The Abstract Art of Jane LaFarge Hamill and Kevin Mack
Authors: Kent Charlotte 
Published: August 2021

Abstract
Although virtual reality (VR) is largely associated with a dependency on realist imagery award-winning visual effects professional Kevin Mack and oil painter Jane LaFarge Hamill use VR to produce abstract works. Abstract art and early abstract film reveal the importance of such experimentation to each medium’s latent potential and how early oddities, in due course, enter the mainstream. The author examines Mack and Hamill’s respective works to propose that experimenting with abstraction in virtual reality is crucial to its unfolding as a creative medium.
The Soundlapse Project: Exploring Spatiotemporal Features of Wetland Soundscapes
Authors: Otondo Felipe , Rabello-Mestre André 
Published: August 2021

Abstract
This article discusses an interdisciplinary project aimed at highlighting the acoustical heritage of wetlands by means of field recordings and a novel time-lapse montage method. The authors discuss a site-specific sound installation that was designed using original wetlands field recordings, live processing and spatial audio multichannel reproduction. The discussion focuses on spatial and temporal features of different types of recorded wetlands soundscapes. Future developments of this project will consider the implementation of a standalone spatiotemporal application, to be used in the context of virtual reality applications, game audio and interactive dance performance.
Cybernetic Performance Ecosystems: The Im-Medea Cycle
Authors: Polymeneas-Liontiris Thanos , Demeglio M. Eugenia 
Published: August 2021

Abstract
This article discusses a series of experimental musical theater performances that took place between 2015 and 2017. This art-based research applies cybernetic and system theory principles at different levels (i.e. compositionally aesthetically dramaturgically) in the creative process to demonstrate how qualities of the posthuman condition can manifest in experimental music theater. The article presents a number of these experimental musical theater performances and introduces the term cybernetic performance ecosystem
Liverpool LASER Talks: A Community “Studio-Laboratory”?
Authors: Roughley Mark , Wilkinson Caroline 
Published: August 2021

Abstract
Liverpool LASER talks encourage artists, researchers and the public to question the work carried out by artists and scientists in transdisciplinary art-science spaces by recognizing shared aims, examining processes and constructing a shared language. In this paper, the authors reflect upon their first year as LASER hosts and propose that Liverpool LASER events—supported by an accessible network of leading artists and scientists—act as community “studio-laboratories,” spaces where speakers and publics engage in two-way conversations, present and gain confidence in their ideas, gather feedback on new concepts and outputs, and facilitate knowledge transfer.
Mesoscale Gravity Waves and Midlatitude Weather: A Tribute to Fuqing Zhang
Authors: Ruppert James H. , Koch Steven E. , Chen Xingchao , Du Yu , Seimon Anton , Sun Y. Qiang , Wei Junhong , Bosart Lance F. 
Published: August 2021

Abstract
Over the course of his career, Fuqing Zhang drew vital new insights into the dynamics of meteorologically significant mesoscale gravity waves (MGWs), including their generation by unbalanced jet streaks, their interaction with fronts and organized precipitation, and their importance in midlatitude weather and predictability. Zhang was the first to deeply examine “spontaneous balance adjustment”—the process by which MGWs are continuously emitted as baroclinic growth drives the upper-level flow out of balance. Through his pioneering numerical model investigation of the large-amplitude MGW event of 4 January 1994, he additionally demonstrated the critical role of MGW–moist convection interaction in wave amplification. Zhang’s curiosity-turned-passion in atmospheric science covered a vast range of topics and led to the birth of new branches of research in mesoscale meteorology and numerical weather prediction. Yet, it was his earliest studies into midlatitude MGWs and their significant impacts on hazardous weather that first inspired him. Such MGWs serve as the focus of this review, wherein we seek to pay tribute to his groundbreaking contributions, review our current understanding, and highlight critical open science issues. Chief among such issues is the nature of MGW amplification through feedback with moist convection, which continues to elude a complete understanding. The pressing nature of this subject is underscored by the continued failure of operational numerical forecast models to adequately predict most large-amplitude MGW events. Further research into such issues therefore presents a valuable opportunity to improve the understanding and forecasting of this high-impact weather phenomenon, and in turn, to preserve the spirit of Zhang’s dedication to this subject.