bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collaborative writing in L2 classrooms: A research agenda
Authors: Li Mimi , Zhang Meixiu 
Published: October 2021

AbstractResearch on second language (L2) collaborative writing (CW) has proliferated over the recent decade and will continue to bloom due to the changing landscape of writing and learning in the digital age. This article provides a research agenda on CW in L2 classrooms. We illustrate six research themes for future research inquiry by pointing out the research gap, following a brief review of theoretical frameworks and existing empirical efforts on CW. We then expound on six specific research tasks that we deem to be pressing for this domain to progress, including more attention to multimodal CW, expanded frameworks for analyzing peer interaction and writing products, deployment of underused research techniques and improved research practice, development of CW assessment practice, as well as the inquiry of practitioners’ input on CW. We hope to provide guidance for future research endeavors by identifying avenues of investigations on CW and meanwhile contribute to the trajectory of vibrant research on L2 writing and language learning.
Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts
Authors: Gustafsson Hanna C. , Nolvi Saara , Sullivan Elinor L. , Rasmussen Jerod M. , Gyllenhammer Lauren E. , Entringer Sonja , Wadhwa Pathik D. , O'Connor Thomas G. , Karlsson Linnea , Karlsson Hasse , Korja Riikka , Buss Claudia , Graham Alice M. , Nigg Joel T. 
Published: October 2021

AbstractHigh levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. The positive and negative affect domains are prime examples of Research Domain Criteria (RDoC) concepts that may enrich a multilevel mechanistic map of psychopathology risk. Utilizing both variable-centered and person-centered approaches, the current study examined whether levels and trajectories of infant negative and positive emotionality, considered either in isolation or together, predicted children's ADHD symptoms at 4 to 8 years of age. In variable-centered analyses, higher levels of infant negative affect (at as early as 3 months of age) were associated with childhood ADHD symptoms. Findings for positive affect failed to reach statistical threshold. Results from person-centered trajectory analyses suggest that additional information is gained by simultaneously considering the trajectories of positive and negative emotionality. Specifically, only when exhibiting moderate, stable or low levels of positive affect did negative affect and its trajectory relate to child ADHD symptoms. These findings add to a growing literature that suggests that infant negative emotionality is a promising early life marker of future ADHD risk and suggest secondarily that moderation by positive affectivity warrants more consideration.
Coherence for bicategorical cartesian closed structure
Authors: Fiore Marcelo , Saville Philip 
Published: October 2021

AbstractWe prove a strictification theorem for cartesian closed bicategories. First, we adapt Power’s proof of coherence for bicategories with finite bilimits to show that every bicategory with bicategorical cartesian closed structure is biequivalent to a 2-category with 2-categorical cartesian closed structure. Then we show how to extend this result to a Mac Lane-style “all pasting diagrams commute” coherence theorem: precisely, we show that in the free cartesian closed bicategory on a graph, there is at most one 2-cell between any parallel pair of 1-cells. The argument we employ is reminiscent of that used by Čubrić, Dybjer, and Scott to show normalisation for the simply-typed lambda calculus (Čubrić et al., 1998). The main results first appeared in a conference paper (Fiore and Saville, 2020) but for reasons of space many details are omitted there; here we provide the full development.
Survey about Intention to Engage in Specific Disaster Activities among Disaster Medical Assistance Team Members
Authors: Iyama Keita , Kakamu Takeyasu , Yamashita Kazunori , Shimada Jiro , Tasaki Osamu , Hasegawa Arifumi 
Published: October 2021

AbstractIntroduction:Different disaster activities should be performed smoothly. In relation to this, human resources for disaster activities must be secured. To achieve a stable supply of human resources, it is essential to improve the intentions of individuals responding to each type of disaster. However, the current intention of Disaster Medical Assistance Team (DMAT) members has not yet been assessed.Study Objective:To facilitate a smooth disaster response, this survey aimed to assess the intention to engage in each type of disaster activity among DMAT members.Methods:An anonymous web questionnaire survey was conducted. Japanese DMAT members in the nuclear disaster-affected area (Group A; n = 79) and the non-affected area (Group N; n = 99) were included in the analysis. The outcome was the answer to the following question: “Will you actively engage in activities during natural, human-made, and chemical (C), biological (B), radiological/nuclear (R/N), and explosive (E) (CBRNE) disasters?” Then, questionnaire responses were compared according to disaster type.Results:The intention to engage in C (50), B (47), R/N (58), and E (52) disasters was significantly lower than that in natural (82) and human-made (82) disasters (P <.001). The intention to engage in CBRNE disasters among younger participants (age ≤39 years) was significantly higher in Group A than in Group N. By contrast, the intention to engage in R/N disasters alone among older participants (age ≥40 years) was higher in Group A than in Group N. However, there was no difference between the two groups in terms of intention to engage in C, B, and E disasters. Moreover, the intention to engage in all disasters between younger and older participants in Group A did not differ. In Group N, older participants had a significantly higher intention to engage in B and R/N disasters.Conclusion:Experience with a specific type of calamity at a young age may improve intention to engage in not only disasters encountered, but also other types. In addition, the intention to engage in CBRNE disasters improved with age in the non-experienced population. To respond smoothly to specific disasters in the future, measures must be taken to improve the intention to engage in CBRNE disasters among DMAT members.
Government investment fiscal multipliers: evidence from Euro-area countries
Authors: Deleidi Matteo , Iafrate Francesca , Levrero Enrico Sergio 
Published: October 2021

AbstractThis paper aims to estimate the government investment fiscal multipliers in select European countries for the period 1970–2016. To do this, we combine Structural Vector Autoregression (SVAR) modeling with the Local Projections (LP) approach. We estimate models by also controlling for fiscal foresight, excluding the postcrisis period and distinguishing between Northern and Southern countries. Our findings suggest that an increase in government investment generates a “Keynesian effect” by engendering positive and permanent effects on the GDP level, even when government expenditure expectations are considered. Fiscal multipliers are close to 1 on impact and increase in the years after the implementation of a discretionary fiscal policy.
Morphological and Ultrastructural Studies of Pecten in the Eurasian Tree Sparrow
Authors: Singh Namram S , Dixit Anand S , Khanikar Debashish 
Published: October 2021

AbstractWe studied the fine histological structures of pecten oculi of the Eurasian tree sparrow using various microscopy techniques. The pecten of the tree sparrow was found to be of a pleated type comprising of pleats, bridges, and base. The light microscopic study revealed further that the pleats consist of capillaries of varying sizes, blood vessels, and numerous pigmented cells that give them a black color. Histochemical studies of pecten showed a large deposition of lipid droplets, which were more abundant in the basal area. The transmission electron microscopy displayed capillaries and blood vessels that remain surrounded by a thick fibrous basal membrane. They are formed of endothelial cells having a large lumen and abluminal area with microfolds. Interstitial spaces were found filled with rounded melanocytes, electron-dense pigment granules, and mitochondria. Observations under the scanning electron microscope revealed the presence of a dense vascular network of capillaries and vessels. In addition, large hyalocytes were also observed on the surface of the pleats. The above observations suggest that the histological structure of the pecten of the tree sparrow resembles those present in the pecten of other diurnal birds. However, further investigation is required to ascertain its functional role in birds.
Counterterrorism and the risk of over-classification of situations of violence
Authors: Gaggioli Gloria , Kilibarda Pavle 
Published: October 2021

AbstractRichard Baxter famously stated that “the first line of defence against international humanitarian law is to deny that it applies at all”. While “under-classification” remains an issue today, a parallel trend needs to be acknowledged. This is the tendency to over-classify situations of violence, especially in relation to transnational terrorist organizations such as the so-called Islamic State group or Al-Qaeda. This tendency stems from practical difficulties inherent in the changing operational environment. The last few years have witnessed a proliferation of armed non-State actors that are labelled or designated as terrorists (e.g., in Iraq, Syria, Mali, Nigeria and Yemen). Terrorist groups are characterized by opaque, often volatile organizational structures and tend to operate in decentralized networks rather than clear hierarchies. The formation of splinter groups, changing alliances, temporary reunification and even open hostility among former allies are common phenomena. This complex factual situation has led to the proliferation of theories of conflict classification, many of them arguing in favour of more flexible classification via the loosening of existing standards. Because international humanitarian law is in many respects less protective than international human rights law, particularly regarding the rules on the use of force and detention, classifying a situation of violence as an armed conflict when the threshold has not been met is a problem that should not be underestimated. In this article, we revisit the criteria of intensity and organization, as well as the related matter of the role of motives in conflict classification, considering conflicts involving armed groups described as terrorists. Our goal is to identify minimum requirements that could diminish the risk of over-classification by various stakeholders.
Epigenetics and DOHaD: how translation to predictive testing will require a better public understanding
Authors: Lynch Fiona , Lewis Sharon , Macciocca Ivan , Craig Jeffrey M. 
Published: October 2021

AbstractEpigenetics is likely to play a role in the mediation of the effects of genes and environment in risk for many non-communicable diseases (NCDs). The Developmental Origins of Health and Disease (DOHaD) theory presents unique opportunities regarding the possibility of early life interventions to alter the epigenetic makeup of an individual, thereby modifying their risk for a variety of NCDs. While it is important to determine how we can lower the risk of these NCDs, it is equally important to understand how the public’s knowledge and opinion of DOHaD and epigenetic concepts may influence their willingness to undertake such interventions for themselves and their children. In this review, we provide an overview of epigenetics, DOHaD, NCDs, and the links between them. We explore the issues surrounding using epigenetics to identify those at increased risk of NCDs, including the concept of predictive testing of children. We also outline what is currently understood about the public’s understanding and opinion of epigenetics, DOHaD, and their relation to NCDs. In doing so, we demonstrate that it is essential that future research explores the public’s awareness and understanding of epigenetics and epigenetic concepts. This will provide much-needed information which will prepare health professionals for the introduction of epigenetic testing into future healthcare.
Origin of Three‐Dimensional Crustal Stress Over the Conterminous United States
Authors: Cao Zebin , Liu Lijun 
Published: October 2021

AbstractThe crustal stress field determines continental deformation, including intraplate seismicity and topographic undulations. However, the sources of observed crustal stress patterns remain debated, with proposed mechanisms including lateral variations in gravitational potential energy and mantle flow, the latter of which comprises plate boundary interactions and basal tractions. Here, we present a series of geodynamic models that simultaneously consider lithospheric and mantle dynamics in the same physical framework, based on which we investigate the sources of crustal stress over the conterminous U.S. The data‐oriented nature of these models allows us to systematically explore the relative contributions of different dynamic sources to the three‐dimensional crustal stress field. These models reveal that forces from the plate boundaries play a dominant role in generating the directional pattern of long‐wavelength horizontal crustal stress across the conterminous U.S. In the central U.S., especially regions of high‐topography, lithospheric density heterogeneities locally modify the crustal stress field. Similarly, mantle flow beneath the North American plate modulates crustal stress orientation in the eastern U.S., particularly in regions with thin lithosphere. Furthermore, we find that a denser‐than‐ambient lithospheric mantle beneath the central and eastern U.S. is required to match the observed continental‐scale E‐W topographic contrast.
Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging
Authors: Martinez De La Cruz Braulio , Markus Robert , Malla Sunir , Haig Maria Isabel , Gell Chris , Sang Fei , Bellows Eleanor , Sherif Mahmoud Awad , McLean Denise , Lourdusamy Anbarasu , Self Tim , Bodi Zsuzsanna , Smith Stuart , Fay Michael , Macdonald Ian A. , Fray Rupert , Knight Helen Miranda 
Published: October 2021

AbstractSynaptic plasticity processes, which underlie learning and memory formation, require RNA to be translated local to synapses. The synaptic tagging hypothesis has previously been proposed to explain how mRNAs are available at specific activated synapses. However how RNA is regulated, and which transcripts are silenced or processed as part of the tagging process is still unknown. Modification of RNA by N6-methyladenosine (m6A/m) influences the cellular fate of mRNA. Here, by advanced microscopy, we showed that m6A demethylation by the eraser protein ALKBH5 occurs at active synaptic ribosomes and at synapses during short term plasticity. We demonstrated that at activated glutamatergic post-synaptic sites, both the YTHDF1 and YTHDF3 reader and the ALKBH5 eraser proteins increase in co-localisation to m6A-modified RNAs; but only the readers showed high co-localisation to modified RNAs during late-stage plasticity. The YTHDF1 and YTHFDF3 readers also exhibited differential roles during synaptic maturation suggesting that temporal and subcellular abundance may determine specific function. m6A-sequencing of human parahippocampus brain tissue revealed distinct white and grey matter m6A methylome profiles indicating that cellular context is a fundamental factor dictating regulated pathways. However, in both neuronal and glial cell-rich tissue, m6A effector proteins are themselves modified and m6A epitranscriptional and posttranslational modification processes coregulate protein cascades. We hypothesise that the availability m6A effector protein machinery in conjunction with RNA modification, may be important in the formation of condensed synaptic nanodomain assemblies through liquid-liquid phase separation. Our findings support that m6A demethylation by ALKBH5 is an intrinsic component of the synaptic tagging hypothesis and a molecular switch which leads to alterations in the RNA methylome, synaptic dysfunction and potentially reversible disease states.
Liprins in oncogenic signaling and cancer cell adhesion
Authors: Pehkonen Henna , de Curtis Ivan , Monni Outi 
Published: October 2021

AbstractLiprins are a multifunctional family of scaffold proteins, identified by their involvement in several important neuronal functions related to signaling and organization of synaptic structures. More recently, the knowledge on the liprin family has expanded from neuronal functions to processes relevant to cancer progression, including cell adhesion, cell motility, cancer cell invasion, and signaling. These proteins consist of regions, which by prediction are intrinsically disordered, and may be involved in the assembly of supramolecular structures relevant for their functions. This review summarizes the current understanding of the functions of liprins in different cellular processes, with special emphasis on liprins in tumor progression. The available data indicate that liprins may be potential biomarkers for cancer progression and may have therapeutic importance.
Reduced hippocampal inhibition and enhanced autism-epilepsy comorbidity in mice lacking neuropilin 2
Authors: Eisenberg Carol , Subramanian Deepak , Afrasiabi Milad , Ziobro Patryk , DeLucia Jack , Hirschberg Pamela R. , Shiflett Michael W. , Santhakumar Vijayalakshmi , Tran Tracy S. 
Published: October 2021

AbstractThe neuropilin receptors and their secreted semaphorin ligands play key roles in brain circuit development by regulating numerous crucial neuronal processes, including the maturation of synapses and migration of GABAergic interneurons. Consistent with its developmental roles, the neuropilin 2 (Nrp2) locus contains polymorphisms in patients with autism spectrum disorder (ASD). Nrp2-deficient mice show autism-like behavioral deficits and propensity to develop seizures. In order to determine the pathophysiology in Nrp2 deficiency, we examined the hippocampal numbers of interneuron subtypes and inhibitory regulation of hippocampal CA1 pyramidal neurons in mice lacking one or both copies of Nrp2. Immunostaining for interneuron subtypes revealed that Nrp2−/− mice have a reduced number of parvalbumin, somatostatin, and neuropeptide Y cells, mainly in CA1. Whole-cell recordings identified reduced firing and hyperpolarized shift in resting membrane potential in CA1 pyramidal neurons from Nrp2+/− and Nrp2−/− mice compared to age-matched wild-type controls indicating decrease in intrinsic excitability. Simultaneously, the frequency and amplitude of spontaneous inhibitory postsynaptic currents (sIPSCs) are reduced in Nrp2-deficient mice. A convulsive dose of kainic acid evoked electrographic and behavioral seizures with significantly shorter latency, longer duration, and higher severity in Nrp2−/− compared to Nrp2+/+ animals. Finally, Nrp2+/− and Nrp2−/− but not Nrp2+/+, mice have impaired cognitive flexibility demonstrated by reward-based reversal learning, a task associated with hippocampal circuit function. Together these data demonstrate a broad reduction in interneuron subtypes and compromised inhibition in CA1 of Nrp2−/− mice, which could contribute to the heightened seizure susceptibility and behavioral deficits consistent with an ASD/epilepsy phenotype.
MiR-193b-3p–ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes
Authors: Huang Cong , Zhong Weilong , Ren Xuanyao , Huang Xia , Li Zizhuo , Chen Chaofeng , Jiang Bin , Chen Zhenzhen , Jian Xingling , Yang Lili , Liu Xiaoming , Huang Haiyan , Shen Changbing , Chen Xiaofan , Dou Xia , Yu Bo 
Published: October 2021

AbstractPsoriasis is an auto-inflammatory skin disease characterized by abnormal activation of epidermal keratinocytes, aberrant neovascularization, and dysregulation of immune cells. MicroRNAs are small non-coding RNAs that mainly function in the post-transcriptional regulation of gene expression. Recently, accumulating evidence has demonstrated that expression of microRNAs is dysregulated in psoriasis patients and microRNAs play key roles in psoriasis pathogenesis. Downregulation of miR-193b-3p has been identified to be associated with psoriasis development. However, the precise functions and action mechanisms of miR-193b-3p in psoriasis pathogenesis remain unclear. In this study, we confirmed the downregulation of miR-193b-3p in psoriasis patients, psoriasis-like inflammatory cellular models, and an imiquimod (IMQ) -induced mouse model. A negative correlation was found between miR-193b-3p level and patient Psoriasis Area and Severity Index (PASI) score. Furthermore, miR-193b-3p suppressed proliferation, inflammatory-factor secretion, and the STAT3 and NF-κB signaling pathways in keratinocytes. Importantly, intradermal injection of agomiR-193b-3p blocked, whereas antagomiR-193b-3p augmented, the psoriasis-like inflammation in the IMQ-induced mouse model. Bioinformatics analysis and the dual-luciferase reporter assay showed that miR-193b-3p targets ERBB4 3ʹ untranslated region (UTR). In addition, ERBB4 induced proliferation, inflammatory-factor production, and the STAT3 and NF-κB pathways in keratinocytes. Most importantly, forced expression of ERBB4 could attenuate the effects of miR-193b-3p in keratinocytes, indicating that miR-193b-3p inhibits keratinocyte activation by directly targeting ERBB4. In conclusion, our findings demonstrated that the miR-193b-3p–ERBB4 axis underlies the hyperproliferation and aberrant inflammatory-factor secretion of psoriatic keratinocytes, providing a novel, microRNA-related causal mechanism and a potential therapeutic target in psoriasis.
A long way to go: caspase inhibitors in clinical use
Authors: Dhani Shanel , Zhao Yun , Zhivotovsky Boris 
Published: October 2021

AbstractCaspases are an evolutionary conserved family of cysteine-dependent proteases that are involved in many vital cellular processes including apoptosis, proliferation, differentiation and inflammatory response. Dysregulation of caspase-mediated apoptosis and inflammation has been linked to the pathogenesis of various diseases such as inflammatory diseases, neurological disorders, metabolic diseases, and cancer. Multiple caspase inhibitors have been designed and synthesized as a potential therapeutic tool for the treatment of cell death-related pathologies. However, only a few have progressed to clinical trials because of the consistent challenges faced amongst the different types of caspase inhibitors used for the treatment of the various pathologies, namely an inadequate efficacy, poor target specificity, or adverse side effects. Importantly, a large proportion of this failure lies in the lack of understanding various caspase functions. To overcome the current challenges, further studies on understanding caspase function in a disease model is a fundamental requirement to effectively develop their inhibitors as a treatment for the different pathologies. Therefore, the present review focuses on the descriptive properties and characteristics of caspase inhibitors known to date, and their therapeutic application in animal and clinical studies. In addition, a brief discussion on the achievements, and current challenges faced, are presented in support to providing more perspectives for further development of successful therapeutic caspase inhibitors for various diseases.