bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterising the allergic profile of children with cystic fibrosis
Authors: Faulkner Amy L. , Grayling Michael , Shillitoe Benjamin , Brodlie Malcolm , Michaelis Louise J. 
Published: September 2021

AbstractBackgroundCystic fibrosis (CF) is a genetic condition that affects multiple organ systems. Allergic bronchopulmonary aspergillosis (ABPA) is a well‐recognised problem but other allergic conditions are less well documented in CF.ObjectiveTo characterise the allergic profile of a cohort of children with CF, with a focus on those with ABPA.MethodsA cohort of children with CF were interviewed and retrospective data were collected regarding their allergic histories and other relevant clinical features.ResultsThe cohort included 37 children with median age of 9 years (interquartile range: 6‐12). There was a history of ≥1 allergic condition(s) in 28/37 children (76%). The most common allergic condition was allergic rhinitis (AR) in 21/37 (57%) and 16 of these 21 children (76%) had another allergic condition. All children with ABPA (8) had another allergic condition. In some children ABPA exacerbations appeared to be seasonal, suggesting possible cross‐sensitisation between Aspergillus fumigatus and aeroallergens associated with seasonal AR. Allergic conditions were also common in children with Pseudomonas aeruginosa infection.
Anti‐perovskite materials for energy storage batteries
Authors: Deng Zhi , Ni Dixing , Chen Diancheng , Bian Ying , Li Shuai , Wang Zhaoxiang , Zhao Yusheng 
Published: September 2021

AbstractAnti‐perovskites X3BA, as the electrically inverted derivatives of perovskites ABX3, have attracted tremendous attention for their good performances in multiple disciplines, especially in energy storage batteries. The Li/Na‐rich antiperovskite (LiRAP/NaRAP) solid‐state electrolytes (SSEs) typically show high ionic conductivities and high chemical/electrochemical stability toward the Li‐metal anode, illustrating their great potential for applications in the Li‐metal batteries (LMBs) using nonaqueous liquid electrolyte or all‐solid‐state electrolyte. The antiperovskites have been studied as artificial solid electrolyte interphase for Li‐metal anode protection, film SSEs for thin‐film batteries, and low melting temperature solid electrolyte enabling melt‐infiltration for the manufacture of all‐solid‐state lithium batteries. Transition metal‐doped LiRAPs as cathodes have demonstrated a high discharge specific capacity and good rate capability in the Li‐ion batteries (LIBs). Additionally, the underlying scientific principles in antiperovskites with flexible structural features have also been extensively studied. In this review, we comprehensively summarize the development, structural design, ionic conductivity and ion transportation mechanism, chemical/electrochemical stability, and applications of some antiperovskite materials in energy storage batteries. The perspective for enhancing the performance of the antiperovskites is also provided as a guide for future development and applications in energy storage.image
How do digital technologies influence the dynamic capabilities of micro and small businesses in a pandemic and low‐income country context?
Authors: Owoseni Adebowale , Hatsu Sylvester , Tolani Adedamola 
Published: September 2021

AbstractIt is not clear how extreme disruptions like COVID‐19 pandemic affects the dynamic capabilities (DCs) of micro and small businesses (MSBs) in the context of low‐income countries. Therefore, this study makes sense of how MSBs leverage DCs through digital technologies (DTs). Using mixed‐method and interpretive research approaches, the first phase of the study applied a deductive coding technique to analyze interviews from 30 MSB managers in Ghana. Coding activities revealed 21 DC constructs of MSBs in Ghana. Next, wecontextualizedandsimplifiedthe DC framework by proposing aninterpretiveblueprint of DC framework applicable to Ghana and other low‐income countries. The second phase, through a questionnaire, progressed the research by assessing how DTs influence the 21 DC constructs. Findings suggest thatcollectiveDCs of MSBs as a business sector did not change in a pandemic situation; nonetheless, the extent to which MSBs demonstrate DCs increased by up to 82%; and the use of DTs such as mobile payment and social media tools increased significantly.Interpretive reflectionson the research outcomes argued that whilst the collective DCs of MSBs remain the same, each MSB uniquely explored opportunities by manifesting different combinations of DC constructs and DTs, at varying extents, and the knowledge of how MSB combines DCs could promote MSB management and digital innovation as low‐income countries seek to recover from the COVID‐19 economic downturn. Consequently, this research extends literature and progresses the UN sustainable development goals 8.3 as it helps to enhance policies that promote digital innovation, entrepreneurship, and growth of MSBs.
Intravenous administration of three multiwalled carbon nanotubes to female rats and their effect on urinary biochemical profile
Authors: Mortensen Ninell P. , Snyder Rodney W. , Pathmasiri Wimal , Moreno Caffaro Maria , Sumner Susan J. , Fennell Timothy R. 
Published: September 2021

AbstractThis study was conducted to investigate the influence of outer diameter (OD) and length (L) of multiwalled carbon nanotubes (MWCNTs) on biodistribution and the perturbation of endogenous metabolite profiles. Three different‐sized carboxylated MWCNTs (NIEHS‐12‐2: L 0.5–2 μm, OD 10–20 nm, NIEHS‐13‐2: L 0.5–2 μm, OD 30–50 nm, and NIEHS‐14‐2: L 10–30 μm, OD 10–20 nm) in water were administered to female Sprague‐Dawley rats as a single intravenous dose of 1 mg/kg MWCNTs. Biodistribution in liver, lung, spleen, and lymph nodes was evaluated in tissue sections at 1 and 7 days' post‐dosing using enhanced darkfield microscopy and hyperspectral imaging. Nuclear magnetic resonance (NMR) analysis was used for biochemical profiling and pathway mapping of endogenous metabolites in urine collected at 24‐h intervals prior to dosing, at Day 1 and Day 7.At Day 1 and Day 7, all three MWCNTs were observed in liver. NIEHS‐12‐2 was observed in spleen, whereas NIEHS‐13‐2 and NIEHS‐14‐2 were not. All three MWCNTs were observed in lymph nodes and lung at Day 7. The urinary biochemical profile showed the highest positive fold change (FC) at Day 7 for the metabolites acetate, alanine, and lactate, whereas 1‐methylnicotinamide, 2‐oxoglutarate, and hippurate had some of the lowest FCs for all three MWCNTs.This study demonstrates that the observed tissue location of MWCNTs is size dependent. Overlaps in the perturbation of endogenous metabolite profiles were found regardless of their size, and the biochemical responses were more profound at Day 7 compared with Day 1, indicating a delayed biological response to MWCNTs.
Factorial validation of sense of community scale using Nigerian mathematics, science, and social science education students: Implication for educational administrators and evaluators
Authors: Ugwuanyi Chika C. , Ugwuanyi Christian S. , Onu Eucharia A. , Kalu Ijeoma A. , Eze Beatrice A. , Ani Mercy I. , Metu Ifeoma C. , Ezeaku Felicia N. , Onuoha Joseph C. , Ugwu Chidinma B. A. , Okeke Anulika M. , Odo Innocent O. , Ugwuanyi Chiamaka K. , Eze Uche N. 
Published: September 2021

AbstractThe ugly occurrences of security breaches have made the Nigerian populace to be leaving in fear. The most affected are the teaming adolescents of the school‐age who may not have a good sense of their community. Thus, this study carried out the factorial validation of a 36‐item sense of community scale (SoCS) developed by Cicognani et al. since no such study exists in Nigeria. The instrument was adopted and validated. A sample of 357 students in South East Federal Universities, Nigeria, was used for this study using a simple random sampling technique. The instrument's factorial validation was conducted by subjecting the data obtained to factor analysis to determine its validity and reliability. Besides, the principal component matrix with varimax rotation was used to carry out the exploratory and confirmatory factors analyses, while the root mean square error of approximation (RMSEA) and confirmatory factor index (CFI) were used to determine the data model fit. Findings of the study showed that SoCS demonstrated good reliability (0.89) and model fit (RMSEA = 0.041, CFI = 0.951) in the Nigerian context. SoCS is a reliable scale for measuring the in‐school adolescents' sense of community.
Assessing multidimensional mattering: Development and exploratory validation of the Mattering in Domains of Life Scale (MIDLS)
Authors: Scarpa Michael P. , Zopluoglu Cengiz , Prilleltensky Isaac 
Published: September 2021

AbstractMattering, defined as feeling valued and adding value, is a basic psychological need with significant explanatory power. Although several specific measures have been introduced to assess the construct, no integrated, multidimensional measure exists. This limits the ability of researchers to investigate mattering in ecological contexts. This paper seeks to address this gap by introducing the Mattering in Domains of Life Scale (MIDLS) and evaluating its internal structure and convergent validity. Using data from a single, large US representative sample, the analysis validated the overall hypothesized factor structure, consisting of feeling valued and adding value across the personal, interpersonal, occupational, and community domains, as well as overall mattering. Convergent validity was assessed by comparing the various MIDLS subscales to eight established scales. Overall results provide evidence that the MIDLS is a valid scale measuring an essentially unidimensional construct composed of eight subdomains.
Long noncoding RNAs: A novel insight in the leukemogenesis and drug resistance in acute myeloid leukemia
Authors: Kirtonia Anuradha , Ashrafizadeh Milad , Zarrabi Ali , Hushmandi Kiavash , Zabolian Amirhossein , Bejandi Atefe K. , Rani Reshma , Pandey Amit K. , Baligar Prakash , Kumar Vinit , Das Bhudev C. , Garg Manoj 
Published: September 2021

AbstractAcute myeloid leukemia (AML) is a common hematological disorder with heterogeneous nature that resulted from blocked myeloid differentiation and an enhanced number of immature myeloid progenitors. During several decades, different factors, including cytogenetic, genetic, and epigenetic have been reported to contribute to the pathogenesis of AML by inhibiting the differentiation and ensuring the proliferation of myeloid blast cells. Recently, long noncoding RNAs (lncRNAs) have been considered as potential diagnostic, therapeutic, and prognostic factors in different human malignancies including AML. Altered expression of lncRNAs is correlated with the transformation of hematopoietic stem and progenitor cells into leukemic blast cells because of their distinct role in the key cellular processes. We discuss the significant role of lncRNAs in the proliferation, survival, differentiation, leukemic stem cells in AML and their involvement in different molecular pathways (insulin‐like growth factor type I receptor, FLT3, c‐KIT, Wnt, phosphatidylinositol 3‐kinase/protein kinase‐B, microRNAs), and associated mechanisms such as autophagy, apoptosis, and glucose metabolism. In addition, we aim to highlight the role of lncRNAs as reliable biomarkers for diagnosis, prognosis, and drug resistance for precision medicine in AML.
Why Australian female high school students do not choose construction as a career: A qualitative investigation into value beliefs about the construction industry
Authors: Carnemolla Phillippa , Galea Natalie 
Published: September 2021

AbstractBackgroundThe construction industry remains male dominated, despite the efforts of business and educational institutions to attract women into construction careers. Previous research has examined why female university students study construction management or engineering. To complement this knowledge, there is an opportunity to understand why so many Australian female high school students do not choose to pursue construction‐related careers.PurposeFramed in motivational theory, the purpose of the study was to understand why Australian female high school students do not choose a construction‐related career by answering the question: How do the value beliefs of female high school students contribute to a rejection of the construction sector as a career choice?Design/methodApplying a qualitative methodology, we report on semistructured interviews with a sample of 15 Australian female high school students. Interview transcripts were inductively analyzed to reveal themes that were overlaid onto Eccles' expectancy–value theory to deepen our understanding of the values expressed by students when discussing their reasons for not wanting a career in construction.ResultsResults revealed five themes: lack of awareness; lack of self‐alignment; effect of male domination; sector esteem; and parental, teacher, and curriculum influence. Responses revealed the range of values contributing to the decision not to consider the construction industry.ConclusionThe paper concludes by suggesting that to increase the participation of young women in the Australian construction industry, the sector should respond to the value beliefs held by female high school students. It should transform the perception of construction into one of a profession that is relevant, valuable, and enjoyable for young women.
Incorporating genetic counseling into the evaluation of pediatric bone marrow failure
Authors: Schneider Kami Wolfe , Suttman Alexandra , McKinney Christopher , Giller Roger , Dollerschell Kaylee , Nakano Taizo A. 
Published: September 2021

AbstractThe timely identification of germline genetic causes of pediatric bone marrow failure (BMF) impacts medical screening practices, family counseling, therapeutic decision‐making, and risk of progression to myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). At diagnosis, treatment decisions need to be made quickly to mitigate risks associated with profound cytopenias. As genetic testing options are rapidly evolving, an efficient multi‐disciplinary approach and algorithm, including early involvement of a genetics team, is needed to expedite diagnosis and therapeutic decision‐making. This process aids in the identification of appropriate candidates for molecular genetic testing. We present our single center experience reviewing the implementation of genetic counseling and a diagnostic and therapeutic algorithm used to guide genetic evaluation of pediatric BMF. Disease‐specific next‐generation sequencing (NGS) panels were most often pursued in patients who presented with a clinical phenotype consistent with a known inherited BMF syndrome and when trying to reduce incidental or uninformative results. Broader BMF NGS panels were most often utilized when unable to narrow the suspected etiology to a single disorder. Whole exome sequencing helped with optimizing treatment decision‐making in higher risk children with BMF who required expedited hematopoietic stem cell transplantation. The experience has led to improvements to our process for evaluating patients with BMF.
Edge colorings and circular flows on regular graphs
Authors: Mattiolo Davide , Steffen Eckhard 
Published: September 2021

AbstractLet be the circular flow number of a bridgeless graph . By Steffen it was proved that, for a bridgeless ‐regular graph , where is a positive integer, if and only if has a perfect matching such that is bipartite. This implies that is a class 1 graph. For , all graphs with circular flow number bigger than 4 are class 2 graphs. We show that, for all , . This was conjectured to be true by Steffen. Moreover we prove that, for all , is a ‐regular class 1 graph with no perfect matching whose removal leaves a bipartite graph. We further disprove the conjecture that every ‐regular class 1 graph has circular flow number at most .
4‐Separations in Hajós graphs
Authors: Xie Qiqin , Xie Shijie , Yu Xingxing , Yuan Xiaofan 
Published: September 2021

AbstractAs a natural extension of the Four Color Theorem, Hajós conjectured that graphs containing no ‐subdivision are 4‐colorable. Any possible counterexample to this conjecture with minimum number of vertices is called a Hajós graph. Previous results show that Hajós graphs are 4‐connected but not 5‐connected. A ‐separation in a graph is a pair of edge‐disjoint subgraphs of such that , , and for . In this paper, we show that Hajós graphs do not admit a 4‐separation such that and can be drawn in the plane with no edge crossings and all vertices in incident with a common face. This is a step in our attempt to reduce Hajós' conjecture to the Four Color Theorem.
New criteria of resectability for pancreatic cancer: A position paper by the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery (JSHBPS)
Authors: Oba Atsushi , Del Chiaro Marco , Satoi Sohei , Kim Sun‐Whe , Takahashi Hidenori , Yu Jun , Hioki Masayoshi , Tanaka Masayuki , Kato Yoshiyasu , Ariake Kyohei , Wu Y.H. Andrew , Inoue Yosuke , Takahashi Yu , Hackert Thilo , Wolfgang Christopher L. , Besselink Marc G. , Schulick Richard D. , Nagakawa Yuichi , Isaji Shuji , Tsuchida Akihiko , Endo Itaru 
Published: September 2021

AbstractThe symposium “New criteria of resectability for pancreatic cancer” was held during the 33nd meeting of the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery (JSHBPS) in 2021 to discuss the potential modifications that could be made in the current resectability classification. The meeting focused on setting the foundation for developing a new prognosis‐based resectability classification that is based on the tumor biology and the response to neoadjuvant treatment (NAT). The symposium included selected experts from Western and Eastern high‐volume centers who have discussed their concept of resectability status through published literature. During the symposium, presenters reported new resectability classifications from their respective institutions based on tumor biology, conditional status, pathology, and genetics, in addition to anatomical tumor involvement. Interestingly, experts from all the centers reached the agreement that anatomy alone is insufficient to define resectability in the current era of effective NAT. On behalf of the JSHBPS, we would like to summarize the content of the conference in this position paper. We also invite global experts as internal reviewers of this paper for intercontinental cooperation in creating an up‐to‐date, prognosis‐based resectability classification that reflects the trends of contemporary clinical practice.
Telemedicine trends at a comprehensive cancer center during the first wave of the COVID‐19 pandemic
Authors: Moentmann Michael R. , Johnson Jared , Chung Michael T. , Yoo Olivia E. , Lin Ho‐sheng , Yoo George H. 
Published: September 2021

AbstractIntroductionThis article reports on the effects of an early outbreak during the COVID‐19 pandemic on visit volume and telehealth use by various specialists at a comprehensive cancer center.Materials and MethodsThe number of on‐site and telehealth visits (THV) for medical and surgical specialties were obtained from scheduling software.ResultsTotal visits were most drastically limited in April 2020 to a low point of 3139; THV made up 28% of all visits. For head and neck surgery, THV made up 54% and 30% of visits in April and May, respectively. Other specialties, such as psychiatry and palliative care, had higher levels of THV. For most specialties, the rebound in June through September did not make up for visits lost during the outbreak, and fiscal year (FY) 2020 had a 9% loss from FY 2019 with 5786 fewer total annual visits across all specialties.ConclusionsWhile telemedicine was a helpful part of this cancer center's response to the initial COVID‐19 surge, it was not able to replace the in‐person services offered at the same center. The main strategy of physicians at this cancer center was to defer care, with telemedicine being an auxiliary response.
Impact of preoperative COVID infection on the outcomes of planned curative‐intent cancer surgeries in the second wave of the pandemic from a tertiary care center in India
Authors: Pandrowala Saneya , Ramraj Deepak , Shankar Ravi , Chopra Saumya , Das Abhishek , Mishra Aseem , Pandey Durgatosh 
Published: September 2021

AbstractBackgroundSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic was an unforeseen calamity. Sudden disruption of nonemergency services led to disruption of treatment across all specialties. Oncology revolves around the tenet of timely detection and treatment. Disruption of any sort will jeopardize cure rates. The time interval between coronavirus infection and cancer surgery is variable and needs to be tailored to avoid the progression of the disease.MethodsWe analyzed the impact of preoperative coronavirus disease 2019 (COVID‐19) infection on the planned cancer surgery, delay, disease progression, and change of intent of treatment from April 1 to May 31, 2021 at a tertiary care center. All preoperative positive patients were retested after 2 weeks and were considered for surgery if the repeat test was negative and asymptomatic.FindingsOur study included 432 preoperative patients of which 91 (21%) were COVID‐19 positive. Amongst this cohort, 76% were operated and the morbidity and mortality were comparable to the COVID‐19 negative cohort. Around 10% of the COVID‐19 positive were lost to follow up and 10% had disease progression and were deemed palliativeInterpretationSARS‐CoV‐2 infection has adversely impacted cancer care and a 2‐week waiting period postinfection seems to be a safe interval in asymptomatic individuals to consider radical cancer surgery.
Circular RNA hsa_circ_0000730 restrains cell proliferation, migration, and invasion in cervical cancer through miR‐942‐5p/PTEN axis
Authors: Yuan Dan‐Dan , Jia Cun‐De , Yan Ming‐Yu , Wang Jian 
Published: September 2021

AbstractCircular RNAs (circRNAs) play prominent roles in regulating the progression of cancers. This study is aimed to decipher the role of hsa_circ_0000730 in cervical cancer (CC).The differentially expressed circRNAs of CC were screened out from the Gene Expression Omnibus database. qRT‐PCR was used to detect circ_0000730 expression in CC tissues and cell lines, and the Kaplan–Meier curve was adopted to figure out the relationship between circ_000730 expression and the overall survival time of CC patients. BrdU assay and Tanswell assay were utilized to examine the proliferation, migration, and invasion of CC cells. Western blot was adopted to detect PTEN protein expression. Bioinformatics analysis and dual‐luciferase reporter assay were used to examine the target relationship between miR‐942‐5p and circ_0000730 or PTEN, respectively.Circ_0000730 was among the differentially expressed circRNAs in CC. Circ_0000730 was significantly down‐regulated in the cancer tissues of 50 CC patients and CC cell lines. Additionally, underexpression of circ_0000730 was associated with the shorter survival time of CC patients. Gain‐ and loss‐of‐function assays highlighted that circ_0000730 significantly inhibited the proliferation, migration, and invasion of CC cells. Mechanistically, miR‐942‐5p was identified as a downstream target of circ_0000730, and circ_0000730 could positively regulate PTEN expression via repressing miR‐942‐5p in CC cells.Circ_0000730 inhibits the proliferation, migration, and invasion of CC cells via regulating miR‐942‐5p/PTEN axis. Circ_0000730 probably acts as a tumor suppressor in CC, and it may be a candidate target for the treatment of CC.