bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypertension and coronary artery ectasia: a systematic review and meta-analysis study
Authors: Bahremand Mostafa , Zereshki Ehsan , Matin Behzad Karami , Rezaei Mansour , Omrani Hamidreza 
Published: July 2021

AbstractBackgroundCoronary artery ectasia (CAE) is characterized by the enlargement of a coronary artery to 1.5 times or more than other non-ectasia parts of the vessel. It is important to investigate the association of different factors and CAE because there are controversial results between available studies. We perform this systematic review and meta-analysis to evaluate the effects of hypertension (HTN) on CAE.MethodsTo find the potentially relevant records, the electronic databases, including Scopus, PubMed, and Science Direct were searched on 25 July 2019 by two of the authors independently. In the present study, the pooled odds ratio (OR) accompanied by 95 % confidence intervals (CIs) were calculated by a random-effects model. Heterogeneity presented with the I2index. Subgroup analysis and sensitivity analysis by the Jackknife approach was performed.ResultsForty studies with 3,263 cases and 7,784 controls that investigated the association between HTN and CAE were included. The pooled unadjusted OR of CAE in subjects with HTN in comparison by subjects without HTN was estimated 1.44 (95 % CI, 1.24 to 1.68) with moderate heterogeneity (I2 = 41 %, Cochran’s QP = 0.004). There was no evidence of publication bias in the analysis of HTN and CAE with Egger’s test (P = 0.171), Begg’s test (P = 0.179). Nine articles reported the adjusted effect of HTN on CAE by 624 cases and 628 controls. The findings indicated the overall adjusted OR was 1.03 (95 % CI, 0.80 to 1.25) with high heterogeneity (I2 = 58.5 %, Cochran’s QP = 0.013).ConclusionsWe found that when the vessel was in normal condition, HTN was not very effective in increasing the chance of CAE and only increased the CAE chance by 3 %. This is an important issue and a warning to people who have multiple risk factors together. More studies need to be performed to further establish these associations by reported adjusted effects.
Enhanced mosquitocidal efficacy of pyrethroid insecticides by nanometric emulsion preparation towards Culex pipiens larvae with biochemical and molecular docking studies
Authors: Taktak Nehad E. M. , Badawy Mohamed E. I. , Awad Osama M. , Abou El-Ela Nadia E. , Abdallah Salwa M. 
Published: July 2021

Abstract
Background
The growing threat of vector-borne diseases and environmental pollution with conventional pesticides has led to the search for nanotechnology applications to prepare alternative products.

Methods
In the current study, four pyrethroid insecticides include alpha-cypermethrin, deltamethrin, lambda-cyhalothrin, and permethrin were incorporated into stable nanoemulsions. The optimization of nanoemulsions is designed based on the active ingredient, solvent, surfactant, sonication time, sonication cycle, and sonication energy by factorial analysis. The nanoscale emulsions’ droplet size and morphology were measured by dynamic light scattering (DLS) and transmission electron microscopy (TEM), respectively. The toxicity of nanoemulsions against Culex pipiens larvae was evaluated and compared with the technical and commercial formulations. The in vitro assay of adenosine triphosphatase (ATPase), carboxylesterase (CaE), and glutathione-S-transferase (GST) were also investigated. Furthermore, molecular docking was examined to assess the binding interactions between the tested pyrethroids and the target enzymes. Also, an ecotoxicological assessment of potential effects of the tested products on the freshwater alga Raphidocelis subcapitata was determined according to OECD and EPA methods. The emulsifible concentration (EC50) and NOEC (no observed effect concentration) values were estimated for each insecticide and graded according to the GHS to determine the risk profile in aquatic life.

Results
The mean droplet diameter and zeta potential of the prepared pyrethroid nanoemulsions were found to be in the range of 72.00–172.00 nm and − 0.539 to − 15.40 mV, respectively. All insecticides’ nanoemulsions showed significantly high toxicity (1.5–2-fold) against C. pipiens larvae compared to the technical and EC. The biochemical activity data proved that all products significantly inhibited ATPase. However, GST and CaE were significantly activated. Docking results proved that the pyrethroids exhibited a higher binding affinity with CaE and GST than ATPase. The docking scores ranged from − 4.33 to − 10.01 kcal/mol. Further, the biosafety studies of the nanopesticides in comparison with the active ingredient and commercial EC were carried out against the freshwater alga R. subcapitata and the mosquitocidal concentration of nanopesticides was found to be non-toxic.

Conclusion
The mosquitocidal efficacy of nano-pyrethroids formulated in a greener approach could become an alternative to using conventional pesticide application in an environmentally friendly manner.
Heat development at the knife roller during leather shaving
Authors: Witt Tilman , Mondschein Anke , Majschak Jens-Peter , Meyer Michael 
Published: July 2021

Abstract
Leather, which is regularly tanned from whole hides of up to 5 m2, needs a constant thickness over the entire surface in order to be processed into high-quality consumer goods such as shoes, furniture and car interiors. Precise adjustment of the thickness is achieved by shaving. On an industrial scale, rotating knife rollers are used to remove chips from the flesh side of semi-finished leathers whereby adjusting the specified thickness and generating a smooth surface. Care must be taken to prevent the temperature from rising above the denaturation temperature of the leather during shaving in order to avoid any loss of quality. Beside this, temperature rise is always a sign of friction showing avoidable energy expenditure. In order to localize the source of friction during shaving, actual temperature development at the roller knife is studied. Different measuring methods are used to evaluate the temperature increase at the blade roll of the shaving machine. The finite element method is used to thermally simulate the process. Measured temperatures, the geometry of the blade roll and process data are taken into account for modelling the temperature development close to the blade edge. The obtained results enhance the understanding of temperature generating processes during machine operation and allow conclusions about potential improvements in the design of the machine and blades.

Graphical abstract
Collagen peptide provides Streptomyces coelicolor CGMCC 4.7172 with abundant precursors for enhancing undecylprodigiosin production
Authors: Li Xia , Li Meifeng , Guo Junling , Liu Xian , Liao Xuepin , Shi Bi 
Published: July 2021

Abstract
Effective and ecofriendly converting biomass to chemicals is important for sustainable engineering based on the foreseeable shortage of fossil resources. Undecylprodigiosin (UP) is a promising antibiotic, but the direct feeding of pure precursor amino acids makes it costly for large-scale production. Here, collagen peptide (CP), a renewable animal-derived biomass contains abundant precursor amino acids of UP. CP can act as carbon and nitrogen source for the growth of Streptomyces coelicolor CGMCC 4.7172. The plant biomasses including soybean meal, wheat bran, and malt extract were unsuitable for UP prodution. However, 365.40 µg/L UP was detected after 24 h in the media containing CP, and its highest concentration reached 1198.01 µg/L. UP was also detected in the media containing meat hydrolysates of domestic animals, but its initial production time was delayed, and final concentration was lower than that in the medium containing CP only. Compared the fermentation performances of CP and other proteins, CP has a special superiority for UP production. These results revealed that UP biosynthesis may be dependent on amino acid availability of substrates and CP is beneficial for UP production because of its specific amino acid composition.

Graphical abstract
Breast involvement of hematological malignancies: imaging and clinical findings
Authors: Durhan Gamze , Demirkazık Figen 
Published: July 2021

Abstract
Background
Breast involvement of hematological malignancies is a very rare entity. Accurate diagnosis is essential for appropriate treatment. The aim of this study was to clarify the clinical and radiological findings of hematological malignancy breast involvement and to describe possible pitfalls in diagnosis.

Results
The images of 20 patients with breast involvement of hematological malignancies were retrospectively evaluated on ultrasonography, mammography, and magnetic resonance imaging (MRI) and the findings were reported. Bilaterality was seen only in cases with secondary involvement, and there was no marked difference between primary and secondary breast involvement of hematological malignancies. All patients underwent ultrasonography examination. According to ultrasonography, breast masses were most frequently irregular in shape (11/20, 55%) with non-circumscribed margins (11/20, 55%). Posterior acoustic enhancement was noted in 14 cases (70%). Posterior shadowing was not observed in any of the patients. Mammography was available in 10 patients. Microcalcification was not observed in any patient on mammography. MRI was available in four patients. Hyperintensity in T2-weighted images, type 2 or type 3 dynamic curve, and diffusion restriction were observed in all cases.

Conclusions
Hematological malignancies may mimic both benign breast lesions and breast carcinoma. Familiarity with the radiological features of hematological malignancies can help accurate diagnosis.
The ethnic density effect in psychosis: a systematic review and multilevel meta-analysis
Authors: Baker Sophie J. , Jackson Mike , Jongsma Hannah , Saville Christopher W. N. 
Published: July 2021

BackgroundAn ‘ethnic’ or ‘group’ density effect in psychosis has been observed, whereby the risk of psychosis in minority group individuals is inversely related to neighbourhood-level proportions of others belonging to the same group. However, there is conflicting evidence over whether this effect differs between minority groups and limited investigation into other moderators.AimsTo conduct a comprehensive systematic review and meta-analysis of the group density effect in psychosis and examine moderators.MethodFour databases were systematically searched. A narrative review was conducted and a three-level meta-analysis was performed. The potential moderating effect of crudely and specifically defined minority groups was assessed. Country, time, area size and whether studies used clinical or non-clinical outcomes were also tested as moderators.ResultsThirty-two studies were included in the narrative review and ten in the meta-analysis. A 10 percentage-point decrease in own-group density was associated with a 20% increase in psychosis risk (OR = 1.20, 95% CI 1.09−1.32,P< 0.001). This was moderated by crudely defined minority groups (F6,68= 6.86,P< 0.001), with the strongest associations observed in Black populations, followed by a White Other sample. Greater heterogeneity was observed when specific minority groups were assessed (F25,49= 7.26,P< 0.001).ConclusionsThis is the first review to provide meta-analytic evidence that the risk of psychosis posed by lower own-group density varies across minority groups, with the strongest associations observed in Black individuals. Heterogeneity in effect sizes may reflect distinctive social experiences of specific minority groups. Potential mechanisms are discussed, along with the implications of findings and suggestions for future research.
Machine Learning Radiomics Model for Early Identification of Small-Cell Lung Cancer on Computed Tomography Scans
Authors: Shah Rajesh P. , Selby Heather M. , Mukherjee Pritam , Verma Shefali , Xie Peiyi , Xu Qinmei , Das Millie , Malik Sachin , Gevaert Olivier , Napel Sandy 
Published: July 2021

PURPOSE Small-cell lung cancer (SCLC) is the deadliest form of lung cancer, partly because of its short doubling time. Delays in imaging identification and diagnosis of nodules create a risk for stage migration. The purpose of our study was to determine if a machine learning radiomics model can detect SCLC on computed tomography (CT) among all nodules at least 1 cm in size. MATERIALS AND METHODS Computed tomography scans from a single institution were selected and resampled to 1 × 1 × 1 mm. Studies were divided into SCLC and other scans comprising benign, adenocarcinoma, and squamous cell carcinoma that were segregated into group A (noncontrast scans) and group B (contrast-enhanced scans). Four machine learning classification models, support vector classifier, random forest (RF), XGBoost, and logistic regression, were used to generate radiomic models using 59 quantitative first-order and texture Imaging Biomarker Standardization Initiative compliant PyRadiomics features, which were found to be robust between two segmenters with minimum Redundancy Maximum Relevance feature selection within each leave-one-out-cross-validation to avoid overfitting. The performance was evaluated using a receiver operating characteristic curve. A final model was created using the RF classifier and aggregate minimum Redundancy Maximum Relevance to determine feature importance. RESULTS A total of 103 studies were included in the analysis. The area under the receiver operating characteristic curve for RF, support vector classifier, XGBoost, and logistic regression was 0.81, 0.77, 0.84, and 0.84 in group A, and 0.88, 0.87, 0.85, and 0.81 in group B, respectively. Nine radiomic features in group A and 14 radiomic features in group B were predictive of SCLC. Six radiomic features overlapped between groups A and B. CONCLUSION A machine learning radiomics model may help differentiate SCLC from other lung lesions.
Dysregulation of the Hypothalamic-Pituitary-Testicular Axis due to Energy Deficit
Authors: Grossmann Mathis , Wittert Gary A 
Published: July 2021

AbstractContextAlthough gonadal axis dysregulation from energy deficit is well recognized in women, the effects of energy deficit on the male gonadal axis have received much less attention.Evidence acquisitionTo identify relevant articles, we conducted PubMed searches from inception to May 2021.Evidence synthesisCase series and mechanistic studies demonstrate that energy deficit (both acutely over days or chronically over months) either from inadequate energy intake and/or excessive energy expenditure can lower serum testosterone concentration as a result of hypothalamic-pituitary-testicular (HPT) axis dysregulation in men. The extent to which this has clinical consequences that can be disentangled from the effects of nutritional insufficiency, concomitant endocrine dysregulation (eg, adrenal and thyroid axis), and coexisting comorbidities (eg, depression and substance abuse) is uncertain. HPT axis dysfunction is primarily the result of loss of GnRH pulsatility resulting from a failure of leptin to induce kisspeptin signaling. The roles of neuroendocrine consequences of depression, hypothalamic-pituitary-adrenal axis activation, proinflammatory cytokines, Ghrelin, and genetic susceptibility remain unclear. In contrast to hypogonadism from organic pathology of the HPT axis, energy deficit-associated HPT dysregulation is functional, and generally reversible by restoring energy balance.ConclusionsThe clinical management of such men should aim to restore adequate nutrition and achieve and maintain a healthy body weight. Psychosocial comorbidities must be identified and addressed. There is no evidence that testosterone treatment is beneficial. Many knowledge gaps regarding epidemiology, pathophysiology, and treatment remain and we highlight several areas that require future research.
Ventromedial Nucleus of the Hypothalamus Neurons Under the Magnifying Glass
Authors: Khodai Tansi , Luckman Simon M 
Published: July 2021

AbstractThe ventromedial nucleus of the hypothalamus (VMH) is a complex brain structure that is integral to many neuroendocrine functions, including glucose regulation, thermogenesis, and appetitive, social, and sexual behaviors. As such, it is of little surprise that the nucleus is under intensive investigation to decipher the mechanisms which underlie these diverse roles. Developments in genetic and investigative tools, for example the targeting of steroidogenic factor-1-expressing neurons, have allowed us to take a closer look at the VMH, its connections, and how it affects competing behaviors. In the current review, we aim to integrate recent findings into the literature and contemplate the conclusions that can be drawn.
Maroon Choreography
Authors: ife fahima 
Published: July 2021

In Maroon Choreography fahima ife speculates on the long (im)material, ecological, and aesthetic afterlives of black fugitivity. In three long-form poems and a lyrical essay, they examine black fugitivity as an ongoing phenomenon we know little about beyond what history tells us. As both poet and scholar, ife unsettles the history and idea of black fugitivity, troubling senses of historic knowing while moving inside the continuing afterlives of those people who disappeared themselves into rural spaces beyond the reach of slavery. At the same time, they interrogate how writing itself can be a fugitive practice and a means to find a way out of ongoing containment, indebtedness, surveillance, and ecological ruin. Offering a philosophical performance in black study, ife prompts us to consider how we—in our study, in our mutual refusal, in our belatedness, in our habitual assemblage—linger beside the unknown.
Duke University Press Scholars of Color First Book Award recipient
Anabolic-Androgenic Steroid Use in Sports, Health, and Society
Authors: BHASIN SHALENDER , HATFIELD DISA L. , HOFFMAN JAY R. , KRAEMER WILLIAM J. , LABOTZ MICHELE , PHILLIPS STUART M. , RATAMESS NICHOLAS A. 
Published: July 2021

ABSTRACT

This consensus statement is an update of the 1987 American College of Sports Medicine (ACSM) position stand on the use of anabolic-androgenic steroids (AAS). Substantial data have been collected since the previous position stand, and AAS use patterns have changed significantly. The ACSM acknowledges that lawful and ethical therapeutic use of AAS is now an accepted mainstream treatment for several clinical disorders; however, there is increased recognition that AAS are commonly used illicitly to enhance performance and appearance in several segments of the population, including competitive athletes. The illicit use of AAS by competitive athletes is contrary to the rules and ethics of many sport governing bodies. Thus, the ACSM deplores the illicit use of AAS for athletic and recreational purposes. This consensus statement provides a brief history of AAS use, an update on the science of how we now understand AAS to be working metabolically/biochemically, potential side effects, the prevalence of use among athletes, and the use of AAS in clinical scenarios.
Anthropometric, Physiological, and Performance Developments in Cross-country Skiers
Authors: JONES THOMAS W. , LINDBLOM HAMPUS P. , KARLSSON ØYVIND , ANDERSSON ERIK P. , MCGAWLEY KERRY 
Published: July 2021

ABSTRACT

Purpose
This study aimed to describe changes in laboratory-assessed anthropometric and physiological characteristics, training volumes, and competitive performance in national development-team cross-country skiers over a 25-month period, and to analyze whether changes in competitive performance could be predicted by changes in laboratory-assessed qualities and training volumes.

Methods
Data collected over 25 months from 30 national development-team cross-country skiers (14 women, 16 men; age, 18–23 yr) were analyzed retrospectively using multivariate statistics. Anthropometric and physiological characteristics were assessed via dual-energy x-ray absorptiometry and incremental roller-ski treadmill tests, respectively. Total training volumes and distributions of low- and high-intensity training were analyzed from online training diaries, and competitive performance was determined by International Ski Federation (FIS) distance and sprint points.

Results
Whole- and upper-body lean mass increased in the full cohort of skiers (n = 30; both P < 0.05), whereas lower-body lean mass, whole-body fat mass, speed and oxygen uptake (V˙O2) at a blood lactate concentration (BLa) of 2 and 4 mmol·L−1, as well as time-trial completion time, power output, and peak V˙O2, improved in the women only (all P < 0.05). Valid predictive models were identified for female skiers’ best FIS distance points (R
2 = 0.81/Q
2 = 0.51) and changes in FIS distance points (R
2 = 0.83/Q
2 = 0.54), with body mass, fat mass, lean mass, V˙O2peak, and speed at a BLa of 4 mmol·L−1 identified as consistently important variables for projection.

Conclusions
The valid prediction of competitive performance was achieved for women only in distance events. This study suggests that improvements in body composition and aerobic capacity may be more beneficial for elite female development-level skiers than for their male counterparts. These results have implications for athlete selection and performance development.
Qualitative Components of Dyspnea during Incremental Exercise across the COPD Continuum
Authors: PHILLIPS DEVIN B. , NEDER J. ALBERTO , ELBEHAIRY AMANY F. , MILNE KATHRYN M. , JAMES MATTHEW D. , VINCENT SANDRA G. , DAY ANDREW G. , DE-TORRES JUAN P. , WEBB KATHERINE A. , O’DONNELL DENIS E. ,   on behalf of the Canadian Respiratory Research Network
Published: July 2021

ABSTRACT

Introduction
Evaluation of the intensity and quality of activity-related dyspnea is potentially useful in people with chronic obstructive pulmonary disease (COPD). The present study sought to examine associations between qualitative dyspnea descriptors, dyspnea intensity ratings, dynamic respiratory mechanics, and exercise capacity during cardiopulmonary exercise testing (CPET) in COPD and healthy controls.

Methods
In this cross-sectional study, 261 patients with mild-to-very severe COPD (forced expiratory volume in 1 s, 62 ± 25%pred) and 94 age-matched controls (forced expiratory volume in 1 s, 114 ± 14%pred) completed an incremental cycle CPET to determine peak oxygen uptake (V˙O2peak). Throughout exercise, expired gases, operating lung volumes, and dyspnea intensity were assessed. At peak exercise, dyspnea quality was assessed using a modified 15-item questionnaire.

Results
Logistic regression analysis revealed that among 15 dyspnea descriptors, only those alluding to the cluster “unsatisfied inspiration” were consistently associated with an increased likelihood for both critical inspiratory mechanical constraint (end-inspiratory lung volume/total lung capacity ratio ≥0.9) during exercise and reduced exercise capacity (V˙O2peak < lower limit of normal) in COPD (odds ratio (95% confidence interval), 3.26 (1.40–7.60) and 3.04 (1.24–7.45), respectively; both, P < 0.05). Thus, patients reporting “unsatisfied inspiration” (n = 177 (68%)) had an increased relative frequency of critical inspiratory mechanical constraint and low exercise capacity compared with those who did not select this descriptor, regardless of COPD severity or peak dyspnea intensity scores.

Conclusions
In patients with COPD, regardless of disease severity, reporting descriptors in the unsatisfied inspiration cluster complemented traditional assessments of dyspnea during CPET and helped identify patients with critical mechanical abnormalities germane to exercise intolerance.