bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shroom3, a Gene Associated with CKD, Modulates Epithelial Recovery after AKI
Authors: Li Aihua , Cunanan Joanna , Khalili Hadiseh , Plageman Timothy , Ask Kjetil , Khan Ahsan , Hunjan Ashmeet , Drysdale Thomas , Bridgewater Darren 
Published: November 2021

Background
Ischemia-induced AKI resulting in tubular damage can often progress to CKD and is a common cause of nephrology consultation. After renal tubular epithelial damage, molecular and cellular mechanisms are activated to repair and regenerate the damaged epithelium. If these mechanisms are impaired, AKI can progress to CKD. Even in patients whose kidney function returns to normal baseline are more likely to develop CKD. Genome-wide association studies have provided robust evidence that genetic variants in Shroom3, which encodes an actin-associated protein, are associated with CKD and poor outcomes in transplanted kidneys. Here, we sought to further understand the associations of Shroom3 in CKD.

Methods
Kidney ischemia was induced in wild-type (WT) and Shroom3 heterozygous null mice (Shroom3Gt/+
) and the mechanisms of cellular recovery and repair were examined.

Results
A 28-minute bilateral ischemia in Shroom3Gt/+
mice resulted in 100% mortality within 24 hours. After 22-minute ischemic injury, Shroom3Gt/+
mice had a 16% increased mortality, worsened kidney function, and significantly worse histopathology, apoptosis, proliferation, inflammation, and fibrosis after injury. The cortical tubular damage in Shroom3Gt/+
was associated with disrupted epithelial redifferentiation, disrupted Rho-kinase/myosin signaling, and disorganized apical F-actin. Analysis of MDCK cells showed the levels of Shroom3 are directly correlated to apical organization of actin and actomyosin regulators.

Conclusion
These findings establish that Shroom3 is required for epithelial repair and redifferentiation through the organization of actomyosin regulators, and could explain why genetic variants in Shroom3 are associated with CKD and allograft rejection.
El general Balza y la construcción de una memoria alternativa del Ejército argentino
Authors: Mazzei Daniel 
Published: November 2021

La noche del 25 de abril de 1995, el teniente general Martín Balzaleyó, en el programa Tiempo Nuevo, un discurso (conocido como “autocrítica”) que marcó el inicio de una revisión de la memoria histórica del Ejército argentino. No fue sino el primer paso hacia la construcción de una nueva memoria institucional que pretende ser alternativa a la lectura del pasado reciente impuesta por los generales procesistas.La investigación parte de la hipótesis que la “autocrítica” no fue sólo la respuesta a una coyuntura política particular sino que Balza se proponía construir una nueva tradición histórica al tiempo que desligaba al Ejército (como institución) de los crímenes contra la Humanidad cometidos por sus integrantes. Se trataba de recuperar la imagen institucional frente a la sociedad civil y “exorcizar los fantasmas de la dictadura”. A partir de entonces conviven, al interior del Ejército, dos memorias rivales, cada una de las cuales incorporaba sus propios olvidos, en un enfrentamiento “memoria contra memoria”. Para este estudio de la evolución del discurso de Balza han sido seleccionados tres textos claves: la ya citada “autocrítica” de 1995, un discurso de febrero de 1998 y, finalmente la autobiografía escrita en 2001, en la cual la memoria institucional alternativa alcanza su expresión definitiva. Al analizar estos tres textos el artículo propone,entre otras cosas, seguir la evolución del concepto de responsabilidad, reconstruir la relectura de la historia contemporánea del Ejército, los cuestionamientos a las leyes de Obediencia de Vida y Punto Final, y la forma en la que esta operación de memoria utiliza el Nunca más para atacar la teoría “de los dos demonios”.Llegados a este punto debemos preguntarnos si esa versión definitiva que construye Balza, es aceptada más allá de su círculo íntimo, o es tan solo un gesto personal de un jefe con ambiciones políticas. O más aún, ¿estamos ante una nueva conciencia militar? ¿Hasta dónde el Ejército participa de política institucional? ¿Los valores de respeto a la vida y a la democracia, y el relato del pasado reciente que Balza pregonaba como propios son asumidos, compartidos y aceptados por todo el Ejército? Quizás podamos resumir todas estas preguntas en una sola: ¿ha tenido éxito Balza en esta operación por imponer una memoria alternativa institucional al Ejército argentino?
El progreso como ensoñación social. Espacialidades de la modernidad en Rosario, Argentina.
Authors: VERA Paula 
Published: November 2021

En este artículo se trabaja sobre las significaciones sociales que incidieron en la construcción de las espacialidades en la ciudad de Rosario desde 1852 hasta los primeros años del siglo XX, haciendo especial hincapié en la idea de progreso como deseo y sueño colectivo que opera con fuerza simbólica en las materialidades de la ciudad moderna. Esto se observa en los discursos oficiales de los archivos del Concejo Deliberante y otras publicaciones municipales, los discursos periodísticos de la época y cierto discurso historiográfico que contribuyó a formalizar un relato de Rosario como hija de su propio esfuerzo. Se analiza la apropiación y la resignificación de lo que significó ser modernos en el caso de Rosario indagando puntualmente los sentidos que fueron adquiriendo determinados espacios públicos en sus procesos de construcción, la nominación de las calles y los proyectos urbanísticos que imitaban a París como ciudad modelo de la Modernidad. Palabras clave: progreso- imaginarios sociales- espacialidad-Rosario.
Effect of Plant Growth Regulators and Explant Source on the Induction of Callus of Dianthus caryophyllus L.
Authors: Mahood Huda E. 
Published: November 2021

In order to investigate the possibility for in in vitro fast regeneration of Dianthus caryophyllus, different concentrations of Kinetin (Kin), 2,4-Dichlorophenoxy Acetic Acid (2,4-D) had been tested for induction of callus by leaves and stems explant using Murashige and Skoog (MS) medium. After two months in culture, response callus in the induction rate, fresh and dry weight, texture and color were evaluated. MS medium that contained 4.5 mg.L-1 2, 4-D was suitable for callus induction with leaf explants. The combination of 0.4 mg.L-1 Kin and 2.0 mg.L-1 2, 4-D also demonstrated a wonderful induction of callus on stem explants. In addition to the culture medium complemented by Kin and 2, 4-D, the influence of Zeatin at various concentrations (0.0, 0.4, 0.8 or 1.0 mg.L-1) was assessed. In MS medium that contained 0.4 mg.L-1 Kin+ 2.0 mg.L-1 2,4-D+ 1.0 mg.L-1 Zeatin, rapid callus induction and also more callus proliferation from stem explants were detected. Results indicate on callus induction that, Zeatin was more successful than Kin or 2, 4-D, but other combinations directly developed a shoot. Callus obtained from stems explant was friable, white and yellow, while callus from leaf explants was green.
STANDARISASI DAN KADAR FLAVONOID TOTAL EKSTRAK ETIL ASETAT KULIT BATANG NANGKA (Artocapus heterophylus L)
Authors: Purnama Niluh Sri , Hasan Hamsidar , Pakaya Mahdalena Sy 
Published: November 2021

Nangka (Artocarpus heterophylla L) adalah tumbuhan yang banyak terdapat di Indonesia. Hampir seluruh bagian pohon nangka dapat dimanfaatkan sebagai obat herbal dimana senyawa flavonoid terprenilasi merupakan metabolit sekunder utama yang terdapat dalam genus Artocarpus. Di Indonesia penggunaan obat herbal masih bersifat tidak terukur baik dari segi takaran, maupun proses penyiapannya. Sehingga perlu dilakukan standarisasi hal ini dilakukan untuk menjaga konsistensi serta keseragaman dari bahan obat herbal. Penelitian ini bertujuan untuk menentukan parameter standarisasi spesifik dan non spesifik serta menentukan kadar flavonoid total ekstrak etil asetat kulit batang nangka. Metode ekstraksi yang digunakan adalah maserasi bertingkat menggunakan pelarut n-heksan, etil asetat dan metanol. Hasil penelitian mengenai parameter organoleptik dari ekstrak etil asetat kulit batang nangka yaitu berwarna merah kehitaman, bau khas, rasa pahit sepat dengan tekstur kental. Simplisia kulit batang nangka memiliki tiga lapisan warna yaitu abu-abu kehijauan dengan bercak putih, lapisan orange dan lapisan coklat muda dengan permukaan tidak rata dan tebal kulit batang kurang lebih 1 cm, serbuk simplisia kulit batang nangka memiliki fragmen kristal oksalat bentuk prisma, serabut, jaringan gabus hablur, dan parenkim dengan amilum. Ekstrak etil asetat mengandung senyawa flavonoid, dan alkaloid. Dan parameter non spesifik ekstrak etil asetat kulit batang nangka yaitu kadar air 16,97%, susut pengeringan 10,48%, kadar abu 9,78%, kadar abu tidak larut asam 1,58% dan bobot jenis 0,912. Dengan kadar flavonoid ekstrak etil asetat adalah 28,1025 µg/mL.
Cosmologically Coupled Compact Objects: A Single-parameter Model for LIGO–Virgo Mass and Redshift Distributions
Authors: Croker Kevin S. , Zevin Michael , Farrah Duncan , Nishimura Kurtis A. , Tarlé Gregory 
Published: November 2021

Abstract
We demonstrate a single-parameter route for reproducing higher mass objects as observed in the LIGO–Virgo mass distribution, using only the isolated-binary stellar evolution channel. This single parameter encodes the cosmological mass growth of compact stellar remnants that exceed the Tolman–Oppenheimer–Volkoff limit. Cosmological mass growth appears in known solutions to General Relativity with cosmological boundary conditions. We consider the possibility of solutions with cosmological boundary conditions, which reduce to Kerr on timescales short compared to the Hubble time. We discuss complementary observational signatures of these solutions that can confirm or invalidate their astrophysical relevance.
Occurrence of the birds of the Middle Volga Region (South-East of the European part of Russia)
Authors: Klenina Anastasia , Ruchin Alexander , Bykov Evgenii 
Published: November 2021

Birds are the most numerous and widespread group of higher vertebrates. Due to the peculiarities of their biology, birds play an important role in nature and in human life.Ornithological studies described in this publication were conducted in seven regions of the Middle Volga Region (Chuvashia, Mordovia, Tatarstan, Samara, Nizhny Novgorod, Ulyanovsk and Penza Regions) from 1978 to 2021. Visual and acoustic methods were used to study the species composition during field studies. In total, 5065 birdoccurrences belonging to 157 species, 48 families and 19 orders were registered. All occurrences have a geographical reference. The large volume of data collected, the wide geographical coverage and the long-term nature of the observations determined the value of their inclusion in the GBIF and the need for publication in the Biodiversity Data Journal.We are publishing our original data on the coordinates of bird occurrences in the Middle Volga Region for the first time. Most of the original information about bird occurrences was contained in field diaries and was not available to a wide range of researchers. All 5065 occurrences are new to GBIF.
Hippocrate et les autres
Authors: Jouanna Jacques 
Published: November 2021

L’étude comprend trois parties : 1. La division du temps de l’année par les saisons : le problème du nombre des saisons et de l’existence de l’automne depuis Homère et Hésiode jusqu’à Hippocrate, en passant par le poète Alcman. 2. Les dénominations de l’automne dans la Collection hippocratique et les catégories de traités hippocratiques désignant l’automne de façon différente. 3. La division du temps de l’année par le mouvement apparent des astres et du soleil : continuités et innovations d’Homère et Hésiode à Hippocrate. L’innovation majeure dans la Collection hippocratique n’est pas la création de l'automne, mais la mise en pratique de l’équinoxe en utilisant une littérature technique perdue. Une partie du savoir des médecins hippocratiques, notamment sur le double lever des astres, ne se comprend véritablement que par référence à leurs prédécesseurs.
Jeûne, restrictions alimentaires et perte d’appétit dans la Collection hippocratique
Authors: Demont Paul 
Published: November 2021

Le vocabulaire de la restriction alimentaire et les représentations mentales qui lui sont associées sont décrits. Ses occurrences sont réparties d’une façon remarquable dans la Collection hippocratique. Le symptôme de l’absence d’alimentation y est souvent considéré comme extrêmement dangereux et il apparaît dans des contextes variés. La Phèdre de l’Hippolyte d’Euripide peut être rapprochée de cas hippocratiques. Du point de vue de la thérapeutique, où la séquence jeûne + potion ou « cycéon » pour guérir ou, dans le cas des femmes, faire concevoir est fréquente, et a fait l’objet de controverses attestées dans le traité du Régime des maladies aiguës, sont mis en évidence certains points de contact entre rituels religieux et traitements médicaux des traités nosologiques et, surtout, gynécologiques.
Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood
Authors: Storm Benjamin S , Christiansen Dorte , Fure Hilde , Ludviksen Judith K , Lau Corinna , Lambris John D , Woodruff Trent M , Brekke Ole-Lars , Braaten Tonje , Nielsen Erik W , Mollnes Tom Eirik 
Published: November 2021

Abstract
Venous air embolism, which may complicate medical and surgical procedures, activates complement and triggers thromboinflammation. In lepirudin-anticoagulated human whole blood, we examined the effect of air bubbles on complement and its role in thromboinflammation. Whole blood from 16 donors was incubated with air bubbles without or with inhibitors of C3, C5, C5aR1, or CD14. Complement activation, hemostasis, and cytokine release were measured using ELISA and quantitative PCR. Compared with no air, incubating blood with air bubbles increased, on average, C3a 6.5-fold, C3bc 6-fold, C3bBbP 3.7-fold, C5a 4.6-fold, terminal complement complex sC5b9 3.6-fold, prothrombin fragments 1+2 (PTF1+2) 25-fold, tissue factor mRNA (TF-mRNA) 26-fold, microparticle tissue factor 6.1-fold, β-thromboglobulin 26-fold (all p &lt; 0.05), and 25 cytokines 11-fold (range, 1.5–78-fold; all p &lt; 0.0001). C3 inhibition attenuated complement and reduced PTF1+2 2-fold, TF-mRNA 5.4-fold, microparticle tissue factor 2-fold, and the 25 cytokines 2.7-fold (range, 1.4–4.9-fold; all p &lt; 0.05). C5 inhibition reduced PTF1+2 2-fold and TF-mRNA 12-fold (all p &lt; 0.05). C5 or CD14 inhibition alone reduced three cytokines, including IL-1β (p = 0.02 and p = 0.03). Combined C3 and CD14 inhibition reduced all cytokines 3.9-fold (range, 1.3–9.5-fold; p &lt; 0.003) and was most pronounced for IL-1β (3.2- versus 6.4-fold), IL-6 (2.5- versus 9.3-fold), IL-8 (4.9- versus 8.6-fold), and IFN-γ (5- versus 9.5-fold). Antifoam activated complement and was avoided. PTF1+2 was generated in whole blood but not in plasma. In summary, air bubbles activated complement and triggered a C3-driven thromboinflammation. C3 inhibition reduced all mediators, whereas C5 inhibition reduced only TF-mRNA. Combined C5 and CD14 inhibition reduced IL-1β release. These data have implications for future mechanistic studies and possible pharmacological interventions in patients with air embolism.
Diagnostic Accuracy of Hysteroscopic Scoring System in Predicting Endometrial Malignancy and Atypical Endometrial Hyperplasia
Authors: Harika Bhukya , Subbaiah Murali , Maurya Dilip Kumar 
Published: November 2021

Aims and Objectives:
The aim of this study was to determine the diagnostic accuracy of a hysteroscopic scoring system in predicting endometrial cancer and endometrial hyperplasia with atypia.

Materials and Methods:
This is a prospective study involving 95 peri and postmenopausal women with abnormal uterine bleeding who underwent hysteroscopic-guided endometrial biopsy. After the calculation of hysteroscopic score, biopsy was obtained and sent for histopathological examination. Hysteroscopic diagnosis of carcinoma endometrium was made when the total score was ≥16 and a score ≥7 supported a diagnosis of endometrial hyperplasia with atypia.

Results:
Out of the 95 women, 46 (48.4%) women had postmenopausal bleeding. The mean age of women was 50.4 ± 10.3 years. Eight women were diagnosed to have endometrial cancer and eight had endometrial hyperplasia with atypia on histopathological examination. Using a hysteroscopy score ≥16, the sensitivity and specificity were found to be 62.5% and 90.8%, respectively, for diagnosing endometrial cancer. Hysteroscopy score ≥9 was found to be a better cutoff for diagnosing endometrial cancer using Youden index. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for diagnosing endometrial cancer with score ≥9 was 100%, 67.8%, 22.2%, and 100%, respectively. The sensitivity, specificity, PPV, and NPV for diagnosing endometrial hyperplasia with atypia with score ≥7 was found to be 75%, 58.6%, 14.3%, and 96.2%, respectively.

Conclusion:
The hysteroscopic scoring system has a good diagnostic performance when a cutoff score ≥9 is used in predicting endometrial cancer. However, the scoring system has lower diagnostic accuracy in predicting endometrial hyperplasia with atypia.
Relationship between Anthropometric Parameters, Neck Circumference, and Intraocular Pressure among Normal Adults in Ile-Ife
Authors: Feyijimi Adetola O. , Adegbehingbe Bernice Oluwakemi , Adeoye Adenike O. , Ihemedu Chidi 
Published: November 2021

Aim:
To determine the relationship between anthropometric parameters, neck circumference (NC), and intraocular pressure (IOP) among the adult population in Ile-Ife, Nigeria

Method:
A descriptive cross-sectional study was conducted among 450 randomly selected nonglaucoma subjects from the students and staff population of Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. Ethical clearance for the study was obtained from the institution and written informed consent was obtained from subjects. The demographic profile of subjects was documented and measurements of anthropometric parameters, NC, and IOP were carried out. Data were analyzed using statistical software SPSS 23.0. The bivariate linear regression model was used for correlation analysis and the level of statistical significance was set at P < 0.05.

Results:
Four hundred and fifty subjects were examined comprising 194 males (43.1%) and 256 females (56.9%). The mean age was 34.26 ± 11.78 years. The mean values for height, weight, body mass index (BMI), and NC were 1.67 ± 0.09 m, 70.7 ± 14 kg, 25.49 ± 4.91 kg/m2, and 34.65 ± 2.79 cm, respectively. The weight and height were significantly higher in males than in females but BMI was higher in females. The mean IOP for all the subjects was 14.40 ± 3.26 mmHg. Weight, BMI, and IOP significantly increased with age, and mean IOP also significantly increased with increasing height (P = 0.045), weight (P = 0.005), NC (P = 0.0005), and BMI (P = 0.0001).

Conclusion:
Increased weight, BMI, and NC were found to be significantly associated with IOP elevation, which is a risk factor for glaucoma
Connectivity of the Superior Longitudinal Fasciculus II and Executive Function in Children with ADHD
Authors: Ma Larissa , Joykutty Leya , Dick Anthony 
Published: November 2021

Attention-deficit hyperactivity disorder (ADHD) is a common childhood neurodevelopmental disorder marked by inattention, hyperactivity, and impulsiveness. The importance of the Superior Longitudinal Fasciculus II (SLFII), a white matter tract connecting the frontal and parietal regions, to developing executive function has not been established in children who typically have executive function deficits. The present study explored the association between diffusion properties of the SLFII and developing executive function in young children diagnosed with ADHD. A dataset with the performance on the NIH Toolbox Card Sort and the NIH Toolbox Flanker, two executive function tasks, in 59 4-7-year-old children was used, and diffusion-weighted magnetic resonance imaging scans were used to quantify the white matter properties of the bilateral SLFII. The results showed that there was an association between age and performance on the Flanker and Card Sort tasks. As age increased, performance also improved. There was no significant association between white matter properties of the SLFII, birth sex, and the Card Sort and Flanker tasks. As the first study to explore this association in children of this age with ADHD, this result was unexpected suggesting that it may be the case that it is too early in development to detect a strong association. The findings inform contemporary and future investigations into the brain-behavior relations between SLFII and executive function in children with ADHD. With further research, neuroimaging could become a potential diagnostic biomarker for predicting executive function impairments and ADHD symptoms in young children, potentially altering treatment outcomes.
Da vulnerabilidade da Filosofia: um estudo sobre a presença da filosofia como uma disciplina frente às atuais mudanças curriculares no ensino médio
Authors: Ramalho Ellen Maianne Santos Melo 
Published: November 2021

A presença da Filosofia enquanto disciplina escolar no currículo do ensino médio no Brasil, passa por um novo momento histórico. Marcado principalmente por novas legislações educacionais, como a Lei 13.415/17 e a aprovação da Base Nacional Comum Curricular - BNCC, a política educacional brasileira modificou-se substancialmente e ameaça a não permanência da Filosofia no currículo do ensino médio. Desta forma, a partir desse novo contexto político educacional, urge a necessidade de se discutir a presença da Filosofia nas escolas de ensino médio no Brasil, ressaltando mais uma vez, a sua importância. Para tanto, esse trabalho se propõe a responder a problemática: Por que a Filosofia se torna vulnerável dentro do atual contexto político educacional brasileiro? A partir dessa problemática pretendemos corresponder aos seguintes objetivos: Discutir qual o lugar da Filosofia após as mudanças na legislação educacional brasileira; abordar os fatores responsáveis pelo caráter de vulnerabilidade da filosofia e ressaltar o importante papel formativo da Filosofia na educação. Trabalhar a temática do novo ensino médio é bastante relevante, uma vez que o novo ensino médio irá impactar diretamente na vida de milhões de brasileiros e brasileiras.