bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Maternal Serum Estradiol in First Trimester of Multiple Pregnancy Contributes to Small for Gestational Age via DNMT1-Mediated CDKN1C Upregulation
Authors: Hu Xiao-Ling , Shi Shuai , Hou Ning-Ning , Meng Ye , Li Miao , Liu Ai-Xia , Lu Yong-Chao , Li Jing-Yi , Sheng Jian-Zhong , Zhu Yi-Min , Huang He-Feng 
Published: September 2021

AbstractHigh maternal serum estradiol (E2) levels in the first trimester of pregnancy are associated with a high incidence of low birth weight (LBW) and small for gestational age (SGA). This study aimed to investigate the effect of first-trimester high maternal serum E2 levels on fetal growth and the underlying mechanisms in multiple pregnancies. Maternal serum E2 levels of women at 8 weeks of gestation were measured. The expression levels of imprinted genes and DNMT1 were determined by RT-qPCR, and KvDMR1 methylation in embryo tissue, placenta, and newborn cord blood samples was examined by bisulfite sequencing PCR. The effect of E2 on CDKN1C expression was investigated in HTR8 cells. The incidence of SGA was significantly higher in multiple pregnancies reduced to singleton than that in primary singleton pregnancies (11.4% vs. 2.9%) (P < 0.01) and multiple pregnancies reduced to twins than primary twins (38.5% vs. 27.3%) (P < 0.01). The maternal serum E2 level at 8 weeks of gestation increased with the number of fetuses and was negatively correlated with offspring birth weight. CDKN1C and DNMT1 expression was significantly upregulated in embryo tissue, placenta, and cord blood from multiple pregnancies. Furthermore, there was a positive correlation between CDKN1C mRNA expression and KvDMR1 methylation levels. In HTR8 cells, DNMT1 mediated the estrogen-induced upregulation of CDKN1C, which might contribute to SGA. To minimize the risks of LBW and SGA, our findings suggest that abnormally high maternal serum E2 levels should be avoided during the first trimester of multiple pregnancies from assisted reproductive technology (ART).
A framework for modelling cash flow lags
Authors: Armerin Fredrik , Song Han-Suck 
Published: September 2021

AbstractTraditional models of irreversible investment problems assume that the investment starts generating cash flows immediately, i.e., at the same time as the investment is undertaken. Real-world investment situations are characterized by time-to-build or investment lags, which means that there is a time difference between when the investment is made and when the investment starts generating cash flows. We combine two existing models of investment lags to obtain a flexible, yet simple, way of modelling and analyzing the effects of investment lags. Both traditional models, and models that incorporate the effects of time-to-build, typically assume that the expected future cash flows generated by an investment are represented by a single cash flow that reflects the size of the market value of an investment. To reflect real-world cases where investments generate cash flows in several time periods, we present a framework in which cash flows are explicitly allowed to be spread out in time. Our model can be used to incorporate cases where an investment is partially sold in different time periods. Using an irreversible optimal investment timing problem case study, we show how our framework makes it possible to easily compare the effect of different cash flow timings. In this case, the value and the timing of the investment depend on a constant that in a natural way can be decomposed into three parts, thereby showing the influence of the value and timing from the respective parts of the framework.
Prevalence and associated characteristics of youth who trade sex in a representative sample of high school students
Authors: Gerassi Lara B. , Cheng Shih‐Ying , Muentner Luke , Benson Meghan 
Published: September 2021

AbstractIntroductionOur understanding of youths’ sex trading predominantly stems from non‐representative studies with high‐risk populations (e.g. homeless/runaway youth). The purpose of this study is to identify the prevalence and associated characteristics of youth who report sex trading (compared to those who do not) in a representative sample of high school students.MethodsData comes from the 2018 Youth Assessment, a cross‐sectional survey administered to 9th through 12th graders across 24 high schools in Dane County, a predominantly urban area in Wisconsin, U.S.A. All youth who answered the question, “have you ever had sexual contact in order to stay safe or to get something like a place to stay, money, gifts, alcohol or drugs?” were included for secondary data analysis (n = 13,714). Participants were 70% White, 50% female/47% male, and 90% minors. Chi‐square tests and logistic regression analyses were conducted.Results2.47% of youth reported sex trading, of whom 91% were minors. Bivariate analysis revealed significant differences across demographics, economic instability, behavioral health and substance use, delinquency, and romantic/sexual behaviors. Multivariate results suggested that students who reported substance use, cutting class, 3 or more out‐of‐school suspensions, knowing a friend involved in a gang, dating violence, foster care involvement, or identifying as LGBTQ+ were more likely to report sex trading.ConclusionsAlthough the causal order of characteristics analyzed in relation to the sex trading is not known, these findings have important implications for sex trading prevention, assessments, and intervention, particularly among youth with marginalized identities and adverse experiences.
Tree Stand–Related Injuries in Nonadmitted and Admitted Patients at a Level 2 Trauma Center in Michigan: 2015–2019
Authors: Lazzara Alan A. , Ditmer Bailey I. , Doughty Kyle W. , Reynolds Kyle R. 
Published: September 2021

Introduction Tree stand–related injuries (TSRI) are more common than firearm-related injuries in hunters. Most previous studies on the topic used trauma databases that only include admitted patients. This study characterizes injury patterns found in nonadmitted and admitted TSRI patients presenting to a level 2 Michigan trauma center. TSRI prevention interventions are also discussed. Methods Cases were obtained through a retrospective chart review of the Henry Ford Allegiance Health trauma registry and EPSi cost-accounting database from 2015 to 2019. Keywords searched included fall, hunter, tree, tree stand, treestand, ICD 9 diagnosis ( E884.9_Other accidental fall from one level to another), and ICD 10 diagnosis ( W14.XXXA_Fall from tree, initial encounter). We analyzed age, sex, body mass index, injury severity score, disposition, alcohol use, injuries sustained, reported height of fall, and narrative of fall. Results Thirty-three patients were identified. Patient age was 45±13 y (mean±SD). All patients were male. Injury severity score for nonadmitted patients was 2±1 vs 13±11 in admitted patients. Thirty-three percent of cases were nonadmitted; 67% were admitted. The most common injuries sustained were spinal (33%) and lower extremity fractures (15%). The average yearly TSRI case rate was 5.73 per 10,000 hunters in the study area. Conclusions Our study found that spinal and lower extremity fractures were the most common injuries sustained. One-third of our patients were nonadmitted and therefore not included in the Henry Ford Allegiance Health trauma registry. Some nonadmitted patients had significant injuries requiring specialist consultation, orthopedic braces, or outpatient surgery.
Disaster Preparedness Among Women With a Recent Live Birth in Hawaii – Results From the Pregnancy Risk Assessment Monitoring System (PRAMS), 2016
Authors: Strid Penelope , Fok Carlotta Ching Ting , Zotti Marianne , Shulman Holly B. , Awakuni Jane , House L. Duane , Morrow Brian , Kern Judy , Shim Matthew , Ellington Sascha R. 
Published: September 2021

AbstractObjective:The aim of this study was to examine emergency preparedness behaviors among women with a recent live birth in Hawaii.Methods:Using the 2016 Hawaii Pregnancy Risk Assessment Monitoring System, we estimated weighted prevalence of 8 preparedness behaviors.Results:Among 1010 respondents (weighted response rate, 56.3%), 79.3% reported at least 1 preparedness behavior, and 11.2% performed all 8 behaviors. The prevalence of women with a recent live birth in Hawaii reporting preparedness behaviors includes: 63.0% (95% CI: 58.7-67.1%) having enough supplies at home for at least 7 days, 41.3% (95% CI: 37.1-45.6%) having an evacuation plan for their child(ren), 38.7% (95% CI: 34.5-43.0%) having methods to keep in touch, 37.8% (95% CI: 33.7-42.1%) having an emergency meeting place, 36.6% (95% CI: 32.6-40.9%) having an evacuation plan to leave home, 34.9% (95% CI: 30.9-39.2%) having emergency supplies to take with them if they have to leave quickly, 31.8% (95% CI: 27.9-36.0%) having copies of important documents, and 31.6% (95% CI: 27.7-35.8%) having practiced what to do during a disaster.Conclusions:One in 10 women practiced all 8 behaviors, indicating more awareness efforts are needed among this population in Hawaii. The impact of preparedness interventions implemented in Hawaii can be tracked with this question over time.
MOST(?) THEORIES HAVE BOREL COMPLETE REDUCTS
Authors: LASKOWSKI MICHAEL C. , ULRICH DOUGLAS S. 
Published: September 2021

AbstractWe prove that many seemingly simple theories have Borel complete reducts. Specifically, if a countable theory has uncountably many complete one-types, then it has a Borel complete reduct. Similarly, if
$Th(M)$
is not small, then
$M^{eq}$
has a Borel complete reduct, and if a theory T is not
$\omega $
-stable, then the elementary diagram of some countable model of T has a Borel complete reduct.
TIMING THE EMERGENCE AND DEVELOPMENT OF ARABLE FARMING IN SOUTHEASTERN NORWAY BY USING SUMMED PROBABILITY DISTRIBUTION OF RADIOCARBON DATES AND A BAYESIAN AGE MODEL
Authors: Solheim Steinar 
Published: September 2021

ABSTRACTThe paper explores the emergence and development of arable farming in southeastern Norway by compiling and analyzing directly dated cereals from archaeological contexts. By using summed probability distributions of radiocarbon dates and Bayesian modeling, the paper presents the first comprehensive analysis of the directly dated evidence for farming in the region. The models provide a more precise temporal resolution to the development than hitherto presented. The results demonstrate that the introduction of arable farming to southeastern Norway was a long-term development including several steps. Three different stages are pointed out as important in the process of establishing arable farming: the Early and Middle Neolithic, the Late Neolithic, and the Early Iron Age.
On deficiency problems for graphs
Authors: Freschi Andrea , Hyde Joseph , Treglown Andrew 
Published: September 2021

AbstractMotivated by analogous questions in the setting of Steiner triple systems and Latin squares, Nenadov, Sudakov and Wagner [Completion and deficiency problems, Journal of Combinatorial Theory Series B, 2020] recently introduced the notion of graph deficiency. Given a global spanning property
$\mathcal P$
and a graph
$G$
, the deficiency
$\text{def}(G)$
of the graph
$G$
with respect to the property
$\mathcal P$
is the smallest non-negative integer t such that the join
$G*K_t$
has property
$\mathcal P$
. In particular, Nenadov, Sudakov and Wagner raised the question of determining how many edges an n-vertex graph
$G$
needs to ensure
$G*K_t$
contains a
$K_r$
-factor (for any fixed
$r\geq 3$
). In this paper, we resolve their problem fully. We also give an analogous result that forces
$G*K_t$
to contain any fixed bipartite
$(n+t)$
-vertex graph of bounded degree and small bandwidth.
Group cohesion in group-based personal practice
Authors: Maaß Ulrike , Kühne Franziska , Hahn Daniela , Weck Florian 
Published: September 2021

AbstractBackgroundPersonal practice (PP) is an integral component of many psychotherapy training programmes. It aims to promote personal and professional growth and is often conducted in a group format (g-PP). Group cohesion is one of the most researched mechanisms in group psychotherapy, but has rarely been studied in the context of g-PP.Aims and methodThis exploratory study examines the associations between cohesion, satisfaction with g-PP, its impact on personal and professional development, and theoretical orientation in a sample of n = 329 German psychotherapy trainees. Cohesion was assessed with the group questionnaire (GQ-D; Positive Bonding, Positive Working, Negative Relationship).ResultsOverall, participants reported high levels of all outcome variables. Positive Bonding was the strongest predictor of satisfaction with g-PP (β = 0.46, p<.001). While trainees in cognitive behaviour therapy reported significantly better cohesion scores (d≥0.31), trainees in psychodynamic therapy reported significantly higher satisfaction with g-PP and its impact on their developments (d≥0.30).ConclusionsGroup cohesion appears to be an important factor in g-PP that should be actively promoted by group leaders. However, longitudinal study designs are needed to better understand the emergence of cohesion in g-PP as well as potential moderating factors.
ON SOME CONSEQUENCES OF A THEOREM OF J. LUDWIG
Authors: Paškūnas Vytautas 
Published: September 2021

AbstractWe prove some qualitative results about thep-adic Jacquet–Langlands correspondence defined by Scholze, in the$\operatorname {\mathrm {GL}}_2(\mathbb{Q}_p )$residually reducible case, using a vanishing theorem proved by Judith Ludwig. In particular, we show that in the cases under consideration, the globalp-adic Jacquet–Langlands correspondence can also deal with automorphic forms with principal series representations atpin a nontrivial way, unlike its classical counterpart.
Long‐Term Observations of Shoaling Internal Solitary Waves in the Northern South China Sea
Authors: Chang Ming‐Huei , Lien Ren‐Chieh , Lamb Kevin G. , Diamessis Peter J. 
Published: September 2021

AbstractShoaling internal solitary waves (ISWs) were observed at three mooring sites on the upper continental slope in the northern South China Sea over a period of 5–11 months at water depths of 600, 430, and 350 m. Their properties exhibit a fortnightly variation because of their origination from internal tides. ISW amplitudes, current speeds, and propagation speeds are greater and wave widths narrower in summer than in winter, consistent with the effect of increased stratification in summer, as confirmed by Dubreil‐Jacotin‐Long (DJL) solutions. As ISWs propagate up the slope, the differential response of current and propagation speeds to bottom topography provides an opportunity for convective breaking of ISWs. Convective breaking occurs mostly between 430 and 600‐m depths and exhibits a marginal convective instability status such that (a) the maximum current speed remains nearly equal to the propagation speed and (b) for large‐amplitude waves the current speed and propagation speed decrease at nearly the same rate between 600 and 430‐m depths. The marginal convective instability occurs because ISWs adjust gradually to the gently sloping bottom and preserve their structural integrity after the onset of breaking. Vertical velocity variances behind the leading ISWs, which serve as a surrogate for the number of trailing waves, increase when ISWs reach the convective breaking limit, suggesting that convective breaking may accelerate the fission process in leading ISWs or that convective breaking is accompanied by an enhanced nonlinear dispersion of waves trailing ISWs generated by internal tides.
Impact of Assimilating High‐Resolution Atmospheric Motion Vectors on Convective Scale Short‐Term Forecasts: 2. Assimilation Experiments of GOES‐16 Satellite Derived Winds
Authors: Zhao Juan , Gao Jidong , Jones Thomas A. , Hu Junjun 
Published: September 2021

AbstractBuilding on the results from the observing system simulation experiments in Part I, this study investigates the impact of assimilating Geostationary Operational Environmental Satellite‐16 (GOES‐16) derived atmospheric motion vector (AMV) data on the convective scale numerical weather prediction (NWP) by using the National Severe Storms Laboratory (NSSL) three‐dimensional variational (3DVAR) data assimilation (DA) system. The benefit of the AMV DA for short‐term severe weather forecast is assessed with three high‐impact weather events that occurred in spring 2018 and 2019 over the Great Plains of the United States. The results show that the wind and equivalent potential temperature fields associated with the storm environment and the nearby ongoing convection are improved by the AMV DA, which yields better simulation of the boundaries and the subsequent forecasts of storm evolution. For the quasi‐linear or mesoscale convective system, the assimilation of AMVs has a positive impact on the 0–3 h forecasts of composite reflectivity and accumulated precipitation in terms of the shape, location, and magnitude. However, the AMV DA has difficulty in capturing the sharp moisture gradient associated with the dryline and mostly underpredicts the associated scattered storms.
The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells
Authors: Núñez-Vázquez Sonia , Saura-Esteller José , Sánchez-Vera Ismael , Guilbaud Emma , Cosialls Ana M. , Pons Gabriel , Ricci Jean-Ehrland , Iglesias-Serret Daniel , Marchetti Sandrine , Gil Joan 
Published: September 2021

AbstractFluorizoline is a prohibitin-binding compound that triggers apoptosis in several cell lines from murine and human origin, as well as in primary cells from hematologic malignancies by inducing the integrated stress response and ER stress. Recently, it was described that PHB (Prohibitin) 1 and 2 are crucial mitophagy receptors involved in mediating the autophagic degradation of mitochondria. We measured mitophagy in HeLa cells expressing Parkin and in A549, a lung cancer cell line that can undergo mitophagy in a Parkin-independent manner, and we demonstrated that both fluorizoline and rocaglamide A, another PHB-binding molecule, inhibit CCCP- and OA-induced mitophagy. Moreover, we demonstrated that PHBs are mediating Parkin-dependent mitophagy. In conclusion, besides being a potent pro-apoptotic compound, we present fluorizoline as a promising new mitophagy modulator that could be used as anticancer agent.
Macroecological distributions of gene variants highlight the functional organization of soil microbial systems
Authors: Escalas Arthur , Paula Fabiana S , Guilhaumon François , Yuan Mengting , Yang Yunfeng , Wu Linwei , Liu Feifei , Feng Jiaje , Zhang Yuguang , Zhou Jizhong 
Published: September 2021

Abstract
The recent application of macroecological tools and concepts has made it possible to identify consistent patterns in the distribution of microbial biodiversity, which greatly improved our understanding of the microbial world at large scales. However, the distribution of microbial functions remains largely uncharted from the macroecological point of view. Here, we used macroecological models to examine how the genes encoding the functional capabilities of microorganisms are distributed within and across soil systems. Models built using functional gene array data from 818 soil microbial communities showed that the occupancy-frequency distributions of genes were bimodal in every studied site, and that their rank-abundance distributions were best described by a lognormal model. In addition, the relationships between gene occupancy and abundance were positive in all sites. This allowed us to identify genes with high abundance and ubiquitous distribution (core) and genes with low abundance and limited spatial distribution (satellites), and to show that they encode different sets of microbial traits. Common genes encode microbial traits related to the main biogeochemical cycles (C, N, P and S) while rare genes encode traits related to adaptation to environmental stresses, such as nutrient limitation, resistance to heavy metals and degradation of xenobiotics. Overall, this study characterized for the first time the distribution of microbial functional genes within soil systems, and highlight the interest of macroecological models for understanding the functional organization of microbial systems across spatial scales.
Long noncoding RNA SOX2OT promotes pancreatic cancer cell migration and invasion through destabilizing FUS protein via ubiquitination
Authors: Wang Yan , Zhang Xiong-Fei , Wang Dong-Yan , Zhu Yi , Chen Lei , Zhang Jing-Jing 
Published: September 2021

AbstractPancreatic cancer is a highly aggressive and lethal digestive system malignancy. Our previous studies revealed the correlation of high levels of lncRNA SOX2OT expression with patients’ poor survival outcomes, the promoting role of SOX2OT in proliferation and cycle progression of pancreatic cancer cells, and the in vivo binding of SOX2OT to RNA binding protein FUS, which destabilized the protein expression of FUS. However, the mechanism of SOX2OT binding and inhibiting FUS protein stability remains unclear. In this study, we performed RNA pull-down, cycloheximide-chase, and ubiquitination assays to determine the effect of SOX2OT on FUS ubiquitination, and explored the specific regulatory mechanism of SOX2OT–FUS axis in pancreatic cancer cell migration, invasion, in vivo tumor growth, and metastasis through RNA sequencing. We found that SOX2OT binds to FUS through its 5′ and 3′ regions, resulting in FUS ubiquitination and degradation. The SOX2OT–FUS regulatory axis promotes migration, invasion, tumor growth, and metastasis ability of pancreatic cancer cells. The in-depth elaboration of the SOX2OT–FUS regulatory axis in pancreatic cancer may clarify the mechanism of action of SOX2OT and provide new ideas for pancreatic cancer treatment.
Continuous monitoring system for safe managements of CO2 storage and geothermal reservoirs
Authors: Tsuji Takeshi , Ikeda Tatsunori , Matsuura Ryosuke , Mukumoto Kota , Hutapea Fernando Lawrens , Kimura Tsunehisa , Yamaoka Koshun , Shinohara Masanao 
Published: September 2021

AbstractWe have developed a new continuous monitoring system based on small seismic sources and distributed acoustic sensing (DAS). The source system generates continuous waveforms with a wide frequency range. Because the signal timing is accurately controlled, stacking the continuous waveforms enhances the signal-to-noise ratio, allowing the use of a small seismic source to monitor extensive areas (multi-reservoir). Our field experiments demonstrated that the monitoring signal was detected at a distance of ~ 80 km, and temporal variations of the monitoring signal (i.e., seismic velocity) were identified with an error of < 0.01%. Through the monitoring, we identified pore pressure variations due to geothermal operations and rains. When we used seafloor cable for DAS measurements, we identified the monitoring signals at > 10 km far from the source in high-spatial resolution. This study demonstrates that multi-reservoir in an extensive area can be continuously monitored at a relatively low cost by combining our seismic source and DAS.