bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiosurgery treatment of Anterior Visual Pathway Meningioma (AVPM)
Authors: Zach Leor , Agami Amir , Furman Orit , Moshe Attia , Cohen Zvi , Mizrachi Iris Ben-Bassat , Tam Guy , Zibly Zion , Nissim Ouzi , Spiegelmann Roberto , Huna-Baron Ruth 
Published: May 2021

Abstract
BACKGROUND

Most anterior visual pathway meningiomas (AVPM) are benign and slow-growing, but these tumors may affect visual functions, including visual acuity (VA) and visual field (VF). Due to location, most are treated non-surgically by fractionated stereotactic radiotherapy (FSRT), aiming to prevent tumor progression and visual functions deterioration. Unfortunately, FSRT in itself may affect visual functions. The current preferred treatment regimen (in terms of safety and effectiveness) is undetermined. While most cases are treated with conventional fractionation (cFSRT) – 50.4–54 Gy in 28–30 fractions of 1.8-2 Gy, advances in technology have allowed shortening of total treatment length to hypofractionation (hSRT) – 25-27Gy in 3–5 fractions of 5–9 Gy. Our aim was to evaluate the association of radiotherapy regimen for treating AVPM (cFSRT vs. hSRT) with visual function outcomes (VA, VF) at the last neuro-ophthalmologic evaluation.
METHODS

We conducted a retrospective cohort study of AVPM cases treated at Sheba Medical Center during 2004–2015. We compared cFSRT and hSRT regimens regarding visual function (VA, VF) outcomes at the last neuro-ophthalmologic evaluation. VA was determined by the logarithm of the minimum angle of resolution (LogMAR). VF was determined by the mean deviation (MD). A clinically relevant change in VA was defined as 0.2 LogMAR.
RESULTS

48 patients (13 receiving hSRT, 35 receiving cFSRT) were included, with a median follow-up of 55 months. No significant difference was evident regarding LogMAR or MD of involved eyes at the last evaluation. Six (17%) patients in the cFSRT group experienced clinically relevant VA deterioration in the involved eye, compared with six (46%) in hSRT (p = 0.06).
CONCLUSION

Our findings, using comprehensive and meticulous investigation of visual outcomes, suggest that hSRT may be associated with higher risk for VA and VF deterioration in AVPM especially in ONSM. We recommend the use of cFSRT for ONSM.
The “Backward Looking” Effect in the Continuum Model Considering a New Backward Equilibrium Velocity Function
Authors: Hossain Md Anowar , Jun TANIMOTO 
Published: May 2021

Abstract
In this paper, a new continuum traffic model is developed considering the backward-looking effect through a new positive backward equilibrium speed function. As compared with the conventional full velocity difference model, the backward equilibrium velocity function, which is largely acceptably grounded from mathematical and physical perspectives, plays an important role in significantly enhancing the stability of the traffic flow field. A linear stability condition is derived to demonstrate the flow neutralization capacity of the model, whereas the Korteweg–de Vries–Burgers equation and the attendant analytical solution are deduced using nonlinear analysis to observe the traffic flow behavior near the neutral stability condition. A numerical simulation, used to determine the flow stability enhancement efficiency of the model, is also conducted to verify the theoretical results.
Friction and Wear Behaviours of Polyimide Composites Against Steel Ball Under Rolling-Sliding Compound Motion
Authors: Jiang Yuanyuan , Chen Lei , Xiao Chen , Zhou Ningning , Qing Tao , Qian Linmao 
Published: May 2021

Abstract
Wear of polyimide composites cage due to lubrication failure has a significant impact on the lifetime of bearing, but the related mechanisms are still far from understanding due to the complex movements of bearing parts, such as rolling, sliding et al, in the real operations. Here, the tribological behaviors of polyimide composites against steel ball were studied under a motion compounded with rolling and sliding in comparison with pure sliding. The rolling-sliding motion has a strong influence on the tribological properties of polyimide composites depending on lubrication conditions. Especially under PAO4 oil lubrication, the rolling-sliding motion can facilitate the degradation of polyimide composites, resulting in severe surface wear and aboundant black products forming. The analysis based on XPS and SEM measurements and the compared results from heating sliding test and thermal treatments indicates that the formation of black products is mainly attributed to the tribochemical reactions accompanying with the rupture of C-O and C=O bonds due to high frictional temperature. This process is further facilitated when the PAO4 oil and the metal from counterface participate in the tribochemical reactions.
Covid -19, An Acute on Chronic Metabolic Syndrome? HbA1c-A Marker of Severe Infection.
Authors: Rysz Susanne , Fagerlund Malin Jonsson , Rimes-Stigare Claire , Larsson Emma , Jalde Francesca Campoccia , Mårtensson Johan 
Published: May 2021

Abstract
Background: The comorbidities commonly observed in severe Covid-19 are diagnoses that comprise the metabolic syndrome. The metabolic status of patients when infected with SARS-Cov-2 and its significance for the severity of the disease is not yet fully understood. We investigated the association between respiratory symptoms and the levels of HbA1c in hospitalized patients infected with SARS-CoV-2. Methods: In this retrospective observational study, we included all inpatients at the Karolinska University Hospital, Sweden who had both a positive SARS-CoV-2 test and who had a HbA1c test obtained within 3 months of admission. The primary reasons for hospitalization included trauma, stroke, myocardial infarction, acute or elective surgery as well as infection. Based on HbA1c level and diabetes history, we classified patients into the following dysglycemia categories: prediabetes, unknown diabetes, controlled diabetes or uncontrolled diabetes. We used multivariable logistic regression analysis adjusted for age, sex and body mass index, to assess the association between dysglycemia categories and development of respiratory failure when infected with SARS-CoV-2. Primary outcome was respiratory failure associated with SARS-CoV-2.Results: Of the 385 study patients, 88 (22.9%) had prediabetes, 68 (17.7%) had unknown diabetes, 36 (9.4%) had controlled diabetes, and 83 (21.6%) had uncontrolled diabetes. Overall, 299 (77.7%) patients were admitted with or developed SARS-CoV-2-assoociated respiratory failure during hospitalization. The proportion of patients in need of intensive care (62.5% vs 26.7%, p<0.001), mechanical ventilation (60.9% vs. 26.7%, p<0.001) and renal replacement therapy (14% vs. 1.2%, p<0.001) were all higher in patients with SARS-CoV-2 associated respiratory failure vs. patients without. In addition, 83% of the ICU patients with SARS-CoV-2 associated respiratory failure had a HbA1c > 42 mmol/mol. In multivariable logistic regression analysis compared with no chronic dysglycemia, prediabetes (OR 14.41, 95% CI 5.27-39.43), unknown diabetes (OR 15.86, 95% CI 4.55-55.36), and uncontrolled diabetes (OR 17.61, 95% CI 5.77-53.74) was independently associated with increased risk of SARS-CoV-2-induced respiratory failure.Conclusion: Metabolic imbalance, reflected by elevated HbA1c with or without previous diagnosed diabetes mellitus, was associated with a more severe course of SARS-CoV-2-respratory infection. We suggest that HbA1c could be used as a marker of risk for severe Covid-19.
From Natural Oils to Epoxy Resins: A New Paradigm in Renewable Performance Materials
Authors: Radojčić Dragana , Hong Jian , Petrovic Zoran S. 
Published: May 2021

Abstract
The direct conversion of natural products to useful engineering materials is desirable from both economic and environmental considerations. We are describing the synthesis and properties of 100 % oil-based epoxy resins generated from three epoxidized oils. The catalyst, tris(pentafluorophenyl)borane (B(C6F5)3) in toluene, allowed for controlled cationic polymerization at a very low concentration. Epoxidized oils (derived from triolein, soybean, and linseed oil) had varying epoxy content, rendering resins of different cross-link density. The polymerization was carried out at room temperature followed by post-curing at elevated temperature to speed up conversion. Epoxy resins were amorphous transparent glasses with glass transitions below glass transitions and hard rubbers above. Despite their high cross-link density, these materials show relatively low Tg’s reflecting the aliphatic nature of fatty acids and the presence of plasticizing “dangling” chains. The structure of the triglyceride starting oils influenced the properties of the resulting materials: the more regular structure of triolein compared to the very heterogeneous structures of soybean and linseed oils seemed to have enhanced some properties of the polymer networks. These epoxy polymers are potentially useful as encapsulating and potting compounds for electronic applications.
Changes of antithrombotic prescription in atrial fibrillation patients with acute coronary syndrome or percutaneous coronary intervention and the subsequent impact on long-term outcomes: A longitudinal cohort study
Authors: Lee Chiao-Chin , Chang Chiao-Hsiang , Hung Yuan , Lin Chin-Sheng , Yang Shih-Ping , Cheng Shu-Meng , Yu Fan-Han , Lin Wei-Shiang , Lin Wen-Yu 
Published: May 2021

Abstract
Objectives:The choice of optimal antithrombotic therapy in atrial fibrillation (AF) patients with acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI) remains controversial. The aim of this longitudinal cohort study is to investigate the prescribing pattern of antithrombotic regimen in different cohorts and its subsequent impact. Setting and Design:Longitudinal data from the Tri-Service General Hospital-Coronary Heart Disease (TSGH-CHD) registry, between January 2016 and August 2018 was screened. Participants and method:Patients with prior history of nonvalvular AF, who had ACS presentation or had underwent PCI were selected, and these patients were divided into cohort 1 and cohort 2, according to the index date of antithrombotic prescription before and after the PIONEER AF-PCI study.Primary and secondary outcomes:The primary safety endpoints were composites of major bleeding and/or clinically relevant non-major bleeding. The secondary efficacy endpoints included the occurrence of all-cause mortality, stroke/systemic embolization, nonfatal myocardial infarction (MI), and >30-days coronary revascularization. Results:A total of 121 patients were included into analysis (cohort 1=35; cohort 2=86). Comparing with cohort 1, the prescription rate of triple antithrombotic therapy (TAT) increased from 17.1% to 38.4%, especially the regimen with dual antiplatelet therapy (DAPT) plus low-dose non-vitamin-K dependent oral anticoagulation (NOAC). However, the prescription rate of dual antithrombotic therapy (DAT) decreased (14.3% to 10.5%), as well as the prescription rate of DAPT (68.6% to 51.2%). These changes of antithrombotic prescription across different cohorts were not associated with risk of adverse safety (HR= 0.87; 95% CI, 0.42-1.80, p=0.710) and efficacy outcomes (HR=0.96; 95% CI, 0.40-2.32, p=0.930). Conclusions: Entering the NOAC era, the prescription of TAT increased alongside the decrease in DAT. As the prescription rate of DAPT without anticoagulation remained high, future efforts are mandatory to improve the implementation of guidelines and clinical practice.
Exploring Rare Cellular Activity in More Than One Million Cells by a Trans-scale- Scope
Authors: Ichimura Taro , Kakizuka Taishi , Horikawa Kazuki , Seiriki Kaoru , Kasai Atsushi , Hashimoto Hitoshi , Fujita Katsumasa , Watanabe Tomonobu M. , Nagai Takeharu 
Published: May 2021

Abstract
In many phenomena of biological systems, not a majority, but a minority of cells act on the entire multicellular system causing drastic changes in the system properties. To understand the mechanisms underlying such phenomena, it is essential to observe the spatiotemporal dynamics of a huge population of cells at sub-cellular resolution, which is difficult with conventional tools such as microscopy and flow cytometry. Here, we describe an imaging system named AMATERAS that enables optical imaging with an over-one-centimeter field-of-view and a-few-micrometer spatial resolution. This trans-scale-scope has a simple configuration, composed of a low-power lens for machine vision and a hundred-megapixel image sensor. We demonstrated its high cell-throughput, capable of simultaneously observing more than one million cells. We applied it to dynamic imaging of calcium ions in HeLa cells and cyclic-adenosine-monophosphate in Dictyostelium discoideum, and successfully detected less than 0.01% of rare cells and observed multicellular events induced by these cells.
The Clinical Impact of Metagenomic Next-Generation Sequencing (mNGS) Test in Hospitalized Patients with Suspected Sepsis: A Multicenter Prospective Study.
Authors: Zuo Yi-Hui , Wu Yi-xing , Chen Yan , Li Yu-ping , Song Zhen-ju , Luo Zhe , Ju Min-jie , Shi Min-hua , Xu Shu-yun , Zhou Hua , Li Xiang , Jie Zhi-jun , Liu Xue-dong , Zhang Jing 
Published: May 2021

Abstract
Background:Next Generation Sequencing (NGS) is a newly developed technology and able to detect pathogens rapidly, which may have great importance in early diagnosis and clinical management of infectious diseases. Our study aimed to assess the diagnostic performance and clinical impact of metagenomic NGS (mNGS) in hospitalized patients with suspected sepsis and analyze the suitable population for mNGS test besides culture.Methods:A multi-center, prospective cohort study was performed. We enrolled eligible patients with hospitalized infection, collected demographic and clinical characteristics, and record the 30-day survival. Blood samples were collected on the day of enrollment to perform blood culture and mNGS test. Diagnostic efficacy of mNGS test and blood culture were calculated, and clinical impact of antibiotic regimen modification based on pathogenic test were also analyzed with SPSS22.0 (SPSS Inc, Chicago, IL).Results:We collected demographic and clinical characteristics of patients, and record the 30-day survival. Blood samples were collected on the day of enrollment to perform blood culture and mNGS test. Diagnostic efficacy of mNGS test and blood culture were calculated, and clinical impact of antibiotic regimen modification based on pathogenic test were also analyzed. A total of 277 patients were enrolled and 162 were diagnosed with sepsis. Among patients with 30-day follow-up data, the mortality was 44.8% (121/270). The mNGS test exhibited shorter turn-out time [27.0(26.0, 29.0) vs 96.0(72.0, 140.3) hours, P < 0.001] and higher sensitivity (90.54% vs 36.00%, P < 0.001) than blood culture, especially for fungal infections. The mNGS test showed better performance for patients with mild symptoms, prior antibiotics use, and early stage of infection than blood culture. Higher reads of pathogens detected by mNGS was related to 30-day mortality (P=0.002). The mNGS test was capable of guiding antibiotic regimen modification and ameliorating prognosis. Negative mNGS results helped with antibiotic de-escalation safely.Conclusions mNGS technology may be helpful for patients with possible blood-stream infections, especially in fungal infection and for patients with mild symptoms, prior antibiotics use and early stage of infection. Its role in antibiotic stewardship and ameliorating prognosis warrants further study.Trial registrationThe study was registered on the Chinese Clinical Trial Registry (Number: ChiCTR1800019187) on 01/24/2019 (Retrospectively registered).
Study of the effect of Pioglitazone and Cetuximab on Cancer Stem-like Cellsenriched HT29 cell line
Authors: Alamdar Nasim , Baghaei Kaveh , Farivar Shirin , Hamidieh Amir Ali , Saltanatpour Zohreh 
Published: May 2021

Abstract
One of the major causes of cancer resistance to chemotherapy has been found to be the presence of Cancer Stem Cells (CSCs) in cancerous tissues. Probably, these cells are the source of cancer and the cause of malignancy and recurrence in the affected population. Therefore, it is possible to target CSCs to treat cancer. Since the percentage of CSCs in the total tumor mass is very low, so studies about these cells depend on their isolation and enrichment methods. Some studies have suggested that EMT induction in population of normal epithelial cells and cancer cells by inhibiting of E-cadherin, protects them against chemotherapy, anticancer and apoptosis drugs, moreover they get characteristics of CSCs. So in order to study CSCs can enrich them by inhibiting of E-cadherin in tumor population.In this study, we tried to examine how the effect of Pioglitazone and Cetuximab, two drugs used in chemotherapy of Colon Cancer, on CSCs enriched HT29 cell line (was called HT29-shE) in which CSCs were enriched with induction of EMT by inhibiting of E-cadherin using shRNA.For this purpose, after cell preparation EMT and CSCs markers in Pioglitazone and Cetuximab treated cells were assessed and compared with untreated cells using flow cytometry, real‐time PCR and microscopic monitoring. The findings showed mesenchymal morphology of HT29-shE changed to epithelial morphology after Pioglitazone and Cetuximab treatment, moreover E-cadherin expression increased and Vimentin expression decreased. In addition, expression of CSC markers (CD133+ and CD44+) were reduced in HT29-shE after treatment.
Development of a PET/CT Molecular Radiomics-clinical Model to Predict Local Lymph Node Metastasis of Invasive Lung Adenocarcinoma (≤ 3cm)
Authors: Chang Cheng , Ruan Maomei , Chen Chunji , Yu Hong , Sun Xiaoyan , Ge Yaqiong , Duan Shaofeng , Teng Wenjing , Wu Qianfu , Zhao Wenlu , Qian Xiaohua , Wang Rui , Lei Bei , Wang Lihua , Yan Hui , Liu Ciyi , Liu Liu , Feng Jian , Xie Wenhui 
Published: May 2021

Abstract
Purpose To investigate the value of 18F-FDG PET/CT molecular radiomics combined with the clinical model in predicting local lymph node metastasis (LLNM) with invasive lung adenocarcinoma (≤3cm). Methods 528 lung adenocarcinoma patients were enrolled in this retrospective study. Five models, including integrated PET/CT molecular radiomics-clinical, PET/CT radiomics, PET radiomics, CT radiomics, and clinical models, were developed for the prediction of LLNM. The predictive performance was examined by ROC curve analysis and clinical utility was validated by nomogram and decision curve analysis (DCA) analyses. Results 10 PET/CT radiomics features and 2 clinical characteristics were selected for the construction of the integrated PET/CT molecular radiomics-clinical model. This integrated model performed better than the clinical model and three other radiomics models, and the AUC value of the integrated model was 0.95 (95% CI: 0.93-0.97) in the training group and 0.94 (95% CI: 0.89-0.97) in the test group, respectively. The clinical application of this integrated model in predicting LLNM was also confirmed by nomogram and DCA analyses. Conclusions The integrated PET/CT molecular radiomic-clinical model developed here has the greater advantage to predict LLNM of clinical invasive lung adenocarcinoma (≤3cm) when compared with the simple radiomics model or clinical model.
Adult Primary Pineal Alveolar Rhabdomyosarcoma With FOXO1 Gene Rearrangement and OLIG2 Expression: a Case Report and the Literature Review
Authors: Xie Lesi , Wang Wei , Zhou Hong , Han Zhijiang , Xu Jinghong , Xu Zhihong , Xiang Jingjing 
Published: May 2021

Abstract
Introduction: Alveolar rhabdomyosarcoma (ARMS) is a common malignant soft tissue tumor in child and adolescents. When diagnosed in adults, it is an aggressive, often fatal disease. Intracranial ARMS in adults is rare, especially in the pineal region. Case presentation: A 36-year-old Chinese man presented with a 3-month history of dizziness and 1-month history of headache and unsteady walking. Magnetic resonance imaging of the brain revealed a pineal region lesion with obstructive hydrocephalus. He received ventricular-abdominal shunt and endoscopic-assisted pineal lesion resection.The tumor appears as a solid sheet-like growth of medium-sized round or oval cells with map-like necrosis and some rhabdomyoblasts. Immunohistochemical test revealed that tumor cells were diffusely positive for desmin, myogenin, MyoD1, ALK and CD56. Notably, the tumors were diffusely positive for OLIG2. Fluorescence in situ hybridization confirmed the FOXO-1 gene rearrangement. The final diagnosis of the present case is ARMS of the pineal gland. Conclusions: We presented an extremely rare case of primary ARMS in adult pineal region particularly with expression of OLIG2 and confirmed by PAX3/7-FOXO1 fusion gene detection.
Women’s Decision-Making Autonomy in Maternal Health Service Utilization and Associated Factors among Reproductive Age Women in Southern, Ethiopia
Authors: eshetu kirubel , Gelaw Belete , Lankrew Tadele , Assefa Andualem , Demeke Tsegaye 
Published: May 2021

Abstract
BackgroundWomen autonomy is ability of women to make self-regulating decision to meet their requirement without any one initiation. Women who can autonomously decide on their health utilized maternal health care is poor, even though a lot of effort has been made. Only less than 32% of developing countries women have decision making power to visit maternal health service.ObjectiveTo assess the women decision making autonomy in their maternal health service utilization and its associated factors among reproductive age group women in southern Ethiopia, from March1, 2019 to March 30, 2019.Methods and materialA cross-sectional study design was conducted. Data were analysed using descriptive statistical tests and binary logistic regression was used. All independent variables with p- value of < 0.25 at bivariate analysis were included in multivariate model to determine the predictors of the outcome variable, and to control the confounding factors. For all statistical tests, a P value of < 0.05 was a cut off point for statistical significant.Resultsprevalence of women decision making autonomy in their maternal health service utilization was 58.2% [(AOR = 58.2% (95 %CI (54.2–62.0). Number of family size 2.2 [AOR (95% CI) = 2.2, 95% CI (1.3–3.72)], occupation, 4.3 [AOR (95% CI) = 4.3 95% CI (1.10–9.3)] economic status, 2.2[AOR (95% CI) = 2.2, 95% CI (1.3-.3.72)] respondent age above 35 4.8[AOR(95%CI = 4.8,95%CI(2.3–10)] were the factors significantly associated with decision making autonomy.Conclusionprevalence of women decision making autonomy in their maternal health service utilization was 58.2% which was found to be low. Decision making autonomy was more common with low income, large family size, respondent age and lack women occupation. Improved the women’s decision making by giving Health education on the importance of maternal health services and gender equality recommended to reducing the problem.