bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid molecular detection of pathogenic microorganisms and antimicrobial resistance markers in blood cultures: evaluation and utility of the next-generation FilmArray Blood Culture Identification 2 panel
Authors: Holma Tanja , Torvikoski Jukka , Friberg Nathalie , Nevalainen Annika , Tarkka Eveliina , Antikainen Jenni , Martelin Jari J. 
Published: August 2021

AbstractRapid detection of pathogens causing bloodstream infections (BSI) directly from positive blood cultures is of highest importance in order to enable an adequate and timely antimicrobial therapy. In this study, the utility and performance of a recently launched next-generation fully automated test system, the Biofire FilmArray® Blood Culture Identification 2 (BCID2) panel, was evaluated using a set of 103 well-characterized microbial isolates including 29 antimicrobial resistance genes and 80 signal-positive and 23 signal-negative clinical blood culture samples. The results were compared to culture-based reference methods, MALDI-TOF, and/or 16S rDNA sequencing. Of the clinical blood culture samples, 68 were monomicrobial (85.0%) and 12 polymicrobial (15.0%). Six samples contained ESBL (blaCTX-M), two MRSA (mecA), and three MRSE (mecA) isolates. In overall, the FilmArray BCID2 panel detected well on-panel targets and resistance markers from mono- and polymicrobial samples. However, one Klebsiella aerogenes and one Bacteroides ovatus were undetected, and the assay falsely reported one Shigella flexneri as Escherichia coli. Hence, the sensitivity and specificity for detecting microbial species were 98.8% (95%CI, 95.8–99.9%) and 99.9% (95%CI, 99.8–99.9%), respectively. The sensitivity and specificity for detecting of resistance gene markers were 100%. The results were available within 70 min from signal-positive blood cultures with minimal hands-on time. In conclusion, the BCID2 test allows reliable and simplified detection of a vast variety of clinically relevant microbes causing BSI and the most common antimicrobial resistance markers present among these isolates.
Missing the Popular Vote: Pitfalls in US Democracy and Reform Proposals
Authors: Sell Friedrich L. , Stiefl Jürgen 
Published: August 2021

AbstractOnly a few years ago, it was a widespread belief that globalisation would trigger processes of democratisation worldwide. However, even old and established democracies such as the United States have recently revealed serious weaknesses. This article shows that the US election system is heavily distorted and recommends profound and transparent Electoral College reforms in the election of US presidents. Furthermore, the article highlights the implications the challenges facing American democracy have for Europe.
Policy instruments and self-reported impacts of the adoption of energy saving technologies in the DACH region
Authors: Peneder Michael , Arvanitis Spyros , Rammer Christian , Stucki Tobias , Wörter Martin 
Published: August 2021

AbstractUsing a large sample of enterprises from a survey that was simultaneously conducted in Germany, Austria and Switzerland, we study the self-reported impacts of the adoption of “green” energy saving and related technologies (GETs). Our specific interest is in how different policy instruments associate with energy efficiency, the reduction of $$\hbox {CO}_{2}$$

CO
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emissions, and competitiveness at the firm level. A first set of equations tracks how policy relates to the adoption of green energy technologies in distinct areas such as production, transport, buildings, ICT or renewables. In a second set of equations, we test the perceived impacts of adoption by the managers of the firms. The results confirm a differentiated pattern of varied transmission mechanisms through which policy can affect energy efficiency and $$\hbox {CO}_{2}$$

CO
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emissions, while on average having a neutral impact on the firms’ competitiveness. Further, discarding the conventional dichotomy between incentive-based versus command-and-control type instruments, the results suggest to pursue a comprehensive policy mix, where standards, taxes and subsidies each capitalize on different transmission mechanisms.
A qualitative and quantitative analysis of open citations to retracted articles: the Wakefield 1998 et al.'s case
Authors: Heibi Ivan , Peroni Silvio 
Published: August 2021

AbstractIn this article, we show the results of a quantitative and qualitative analysis of open citations on a popular and highly cited retracted paper: “Ileal-lymphoid-nodular hyperplasia, non-specific colitis and pervasive developmental disorder in children” by Wakefield et al., published in 1998. The main purpose of our study is to understand the behavior of the publications citing one retracted article and the characteristics of the citations the retracted article accumulated over time. Our analysis is based on a methodology which illustrates how we gathered the data, extracted the topics of the citing articles and visualized the results. The data and services used are all open and free to foster the reproducibility of the analysis. The outcomes concerned the analysis of the entities citing Wakefield et al.’s article and their related in-text citations. We observed a constant increasing number of citations in the last 20 years, accompanied with a constant increment in the percentage of those acknowledging its retraction. Citing articles have started either discussing or dealing with the retraction of Wakefield et al.’s article even before its full retraction happened in 2010. Articles in the social sciences domain citing the Wakefield et al.’s one were among those that have mostly discussed its retraction. In addition, when observing the in-text citations, we noticed that a large number of the citations received by Wakefield et al.’s article has focused on general discussions without recalling strictly medical details, especially after the full retraction. Medical studies did not hesitate in acknowledging the retraction of the Wakefield et al.’s article and often provided strong negative statements on it.
Defining “elite” status in sport: from chaos to clarity
Authors: McAuley Alexander B. T. , Baker Joseph , Kelly Adam L. 
Published: August 2021

AbstractThe past two decades have seen a rapid rise in attention towards talent identification, athlete development and skill acquisition. However, there are important limitations to the evidentiary foundations of this field of research. For instance, variability in describing the performance levels of individuals has made it challenging to draw inferences about inter- and intrapopulation differences. More specifically, recent reviews on high performers in sport have noted considerable variation in how terms such as “elite” are used. This may be particularly concerning for researchers in high-performance disciplines, since they regularly struggle with small sample sizes and rely on research synthesis approaches (i.e. meta-analyses and systematic reviews) to inform evidence-based decisions. In this discussion piece, we (a) highlight issues with the application of current terminology, (b) discuss challenges in conceptualizing an improved framework and (c) provide several recommendations for researchers and practitioners working in this area.
Trust and Trust-Engineering in Artificial Intelligence Research: Theory and Praxis
Authors: Chen Melvin 
Published: August 2021

AbstractIn this paper, I will identify two problems of trust in an AI-relevant context: a theoretical problem and a practical one. I will identify and address a number of skeptical challenges to an AI-relevant theory of trust. In addition, I will identify what I shall term the ‘scope challenge’, which I take to hold for any AI-relevant theory (or collection of theories) of trust that purports to be representationally adequate to the multifarious forms of trust and AI. Thereafter, I will suggest how trust-engineering, a position that is intermediate between the modified pure rational-choice account and an account that gives rise to trustworthy AI, might allow us to address the practical problem of trust, before identifying and critically evaluating two candidate trust-engineering approaches.
Paediatric dentistry undergraduate education across dental schools in the Arabian region: a cross-sectional study
Authors: Al-Jundi S. H. , EI Shahawy O. I. , Nazzal H. 
Published: August 2021

Abstract
Purpose
To assess and compare teaching of paediatric dentistry in the undergraduate curriculum among dental schools in the Arabian region.

Methods
A 28-item online cross-sectional questionnaire survey was conducted of undergraduate dental programme directors in the Arab region. The survey included questions related to the programme’s content, method of instruction on specific paediatric dentistry topics as well as the director’s opinion on the level of training obtained by the undergraduate students at the end of the programme.

Results
The final sample included 31 dental schools representing undergraduate programmes in ten Arabian countries (60.8% response rate). All programmes provided theoretical and practical education on communicative behaviour management techniques and caries prevention. Pulpectomy and formocresol pulpotomy were taught in the form of theoretical and practical education in 87.1% and 80.6% of the programmes, respectively. The method of education on common orthodontic topics was mainly theoretical with the exception of space maintainers. Instructions on managing trauma to permanent dentition was theoretical and practical in most programmes (61.3%).
Most respondents rated the level of training of students in behaviour management and caries prevention as good to reasonable, while only 22.6% thought that the level of training was excellent in pulp therapy.

Conclusion
Variations were observed in paediatric dentistry education among undergraduate dental programmes in the Arabian region in terms of topics, instruction methods, year of introduction of paediatric dentistry education, and number of clinical sessions offered. This study establishes a framework for future paediatric dentistry curriculum development and/or improvement in the Arabian region.
Effects of annealing treatment on tribological behavior of tungsten-doped diamond-like carbon film under lubrication (Part 2): Tribological behavior under MoDTC lubrication
Authors: Zhang Shaojun , Zhu Lina , Wang Yanyan , Kang Jiajie , Wang Haidou , Ma Guozheng , Huang Haipeng , Zhang Guang’an , Yue Wen 
Published: August 2021

AbstractMolybdenum dialkyldithiocarbamate (MoDTC) is widely used as a friction modifier in engine lubricating oil. Under MoDTC lubrication, the friction and wear behaviors of tungsten-doped diamond-like carbon (W-DLC) films annealed at 100–400 °C were discussed and evaluated using scanning electron microscopy (SEM), atomic force microscopy (AFM), and Raman spectroscopy. Under (polymerized alpha olefin) PAO + MoDTC lubrication, the coefficient of friction of all samples decreased, but the wear rates of the W-DLC films annealed at 300 °C increased significantly. By interacting with zinc dialkyldithiophosphate (ZDDP), the wear rates of W-DLC films annealed at different temperatures declined significantly owing to the formation of dense phosphate tribofilms on the worn surfaces.
Shoulder Pain — Where Are We Now?
Authors: Walker-Bone Karen , van der Windt Danielle AWM 
Published: August 2021

Abstract
Purpose of Review
Shoulder pain is common and costly. For the past century, diagnosis and management has been based upon presumed patho-anatomical abnormalities. With the evolution of imaging techniques and new insight about the causes of musculoskeletal pain, this review evaluates the evidence that a patho-anatomical approach remains justified.

Recent Findings
Imaging modalities have developed considerably but, so far, have only proven value in evaluating full thickness rotator cuff tears prior to surgery. Correlation between imaging findings and symptoms is otherwise poor, with limited evidence of the value and impact of imaging for decision-making. Much of shoulder pain is chronic and few people have single-site musculoskeletal pain. Pain studies suggest that chronic shoulder pain is associated with both central and peripheral pain sensitisation. Moreover, functional MRI points to an effect of cognitive affective pain processing rather than nociception. Few of the established therapies, medical or surgical, that treat the presumed patho-anatomical cause have been shown to have lasting benefit.

Summary
Much of the evidence suggests that shoulder pain is more similar than different from mechanical low back pain. For most people with shoulder pain, the best approach might well be de-medicalisation, support to (self)manage pain, emphasis on retaining movement and identifying adverse beliefs and risk factors for disability and chronicity. Approaches like this are currently being evaluated and more research is desperately required.
Sigma receptors and neurological disorders
Authors: Piechal Agnieszka , Jakimiuk Alicja , Mirowska-Guzel Dagmara 
Published: August 2021

AbstarctSigma receptors were identified relatively recently, and their presence has been confirmed in the central nervous system and peripheral organs. Changes in sigma receptor function or expression may be involved in neurological diseases, and thus sigma receptors represent a potential target for treating central nervous system disorders. Many substances that are ligands for sigma receptors are widely used in therapies for neurological disorders. In the present review, we discuss the roles of sigma receptors, especially in the central nervous system disorders, and related therapies.Graphic abstract
A change in clinical practice for aural foreign bodies – what we learnt from the coronavirus disease 2019 pandemic
Authors: Ho G C , Thind R , Yap D , Hunt A 
Published: August 2021

AbstractObjectiveThis case series, conducted during the coronavirus disease 2019 pandemic, investigates the impact of leaving aural foreign bodies in situ for a prolonged period of time, including the risk of complications and success rates of subsequent removal attempts.MethodA retrospective study of aural foreign body referrals over a six-month period was carried out.ResultsThirty-four patients with 35 foreign bodies were identified (6 organic and 29 inorganic). The duration of foreign bodies left in situ ranged from 1 to 78 days. Four patients suffered from traumatic removal upon initial attempts. First attempts made by non-ENT specialists (68.8 per cent) all failed and were associated with a high risk of trauma (36.4 per cent).ConclusionBecause of the coronavirus disease 2019 pandemic, this is the first case series to specifically investigate the relationship between the duration of aural foreign bodies left in situ and the risk of complications. Our data suggest that prolonged duration does not increase the incidence of complications.
One year on: assessing the impact of coronavirus disease 2019 on demand for semi-urgent ENT services
Authors: Allen H , Winstanley J , Stubington T J , Judd O 
Published: August 2021

AbstractObjectiveThis study investigated how the coronavirus disease 2019 pandemic has impacted on presentations to ENT first-on-call services.MethodsAll appointments to a rapid access triage clinic from 1 June to 31 August in 2019 and 2020 were reviewed retrospectively and their reasons for consultation classified. A binomial proportion test was used to determine whether the proportions of consultations per presentation differed significantly between years. This analysis was repeated with the number of unique patients per presenting complaint.ResultsThe proportions of nine reasons for consultation differed significantly between 2019 and 2020, including an increase in otitis media and nasal trauma presentations, and a decrease in otitis externa and tonsillitis presentations. Reattendances caused some variation in the frequency of certain diagnoses.ConclusionOur data suggest a shift in the presentations to first-on-call services, which may be a result of changes in patient behaviour and access to healthcare services.
Understanding curriculum design in the perceptions and practices of classroom music teachers in the lower secondary school in England
Authors: Anderson Anthony 
Published: August 2021

AbstractCurriculum design is a domain that infrequently forms a discrete element of initial teacher training, or continuing professional development for music teachers in English secondary schools. Classroom music teachers, teaching Key Stage 3 (KS3) learners (11–14-year olds), are, however, required to design their own curriculum. Teachers are accountable to school leaders for curricula they implement, and the outcomes from their selected approaches. This article discusses classroom music curriculum practices and their significance in music education. The research project was conducted with music teachers from schools in the East and West Midlands of England, utilising questionnaires and semi-structured interviews. Research findings are conceptualised in a model of music curriculum activity. The research thereby facilitates discussion of unacknowledged complexities and tacit teacher planning practices in music curriculum design.
Picking Places and People: Centralizing Provincial Governance in China
Authors: Lu Warren Wenzhi , Tsai Kellee S. 
Published: August 2021

AbstractChina's political system has been characterized by two institutions since the 1980s: an explicit “layer-by-layer administrative hierarchy” and the “appointment of cadres one level down.” There have, however, been two departures from these administrative practices. First, some provinces have “empowered prosperous counties” by placing them in a dual-reporting relationship with both prefecture-level cities and provinces. Second, some provinces have restored personnel control going “two levels down” by appointing key officials at the county and urban district levels of government. These deviations evolved as responses to China's GDP-centric policy environment during the early reform era. Based on field interviews and nationwide analysis of city-level personnel data, this article argues that such adaptations have generated unintended conflicts between provinces and prefecture-level cities. While prior studies of evolutionary change in China highlight the relationship between state and non-state actors, this study demonstrates how interactions among state actors themselves may fundamentally transform the dynamics of administrative governance.
Dealing with change: the Carthusians and Corpus Christi
Authors: DE COUL THOMAS OP 
Published: August 2021

ABSTRACTThe Carthusian Order is known for its conservative attitude towards liturgy and music. This article will explore how this attitude played out in practice when the Carthusians were confronted with the introduction of a major new feast. Since its origins in the late eleventh century, the Order incorporated several new feasts in its calendar. These additions were normally made with a significant delay, and almost always without any new chants created for these feasts. The feast of Corpus Christi provides an interesting case study. Contrary to their habit, the Carthusians were apparently quick to adopt it, and they included most of the chants that were compiled and edited for this feast. In doing this, they took the Cibavit eos Mass and the Sacerdos in aeternum Office, most famously found in a late thirteenth-century libellus (F-Pnm, lat. 1143) as a point of departure. The Mass Propers were largely taken over, but small variations in the melodies raise interesting questions about how they were transmitted. By contrast, the office chants were thoroughly reordered and melodically edited in various ways, giving us a tangible sense of how Carthusians dealt with change.
Impact of atrial septal defect device size on biventricular global and regional function: a two-dimensional strain echocardiographic study
Authors: Alkhateeb Areej , Roushdy Alaa , Hasan-Ali Hosam , Kishk Yehia T. , El Sayegh Aya , Hassan Ayman K.M. 
Published: August 2021

ABSTRACTObjective:In this study, we assessed the acute changes in biventricular longitudinal strain after atrial septal defect transcatheter closure and its relation to the device size.Methods:Hundred atrial septal defect patients and 40 age-matched controls were included. Echocardiography and strain study were performed at baseline and 24 hours and 1 month after the intervention. The study group was divided into two subgroups; group 1: smaller devices were used (mean device size = 1.61 ± 0.05 cm, n = 74) and group 2: larger devices were used (mean device size = 2.95 ± 0.07 cm, n = 26).Results:At baseline, there was a significant difference between the study group and controls as regards right ventricular global longitudinal strain with significant hyperkinetic apex (p = 0.033, p = 0.020, respectively). There was a significant immediate reduction in right ventricular global longitudinal strain (from −24.43 ± 0.49% to −21.62 ± 0.47%, p < 0.001), which showed insignificant improvement after 1-month follow-up. While only left ventricular global longitudinal strain increased after 1 month. Within 24 hours of device closure, all the basal- and mid-lateral segments strains and apical right ventricular strains showed a significant reduction. There was a significant negative correlation between the indexed large device size and an immediate change in the right ventricular global longitudinal strain (r = −0.425, p = 0.034).Conclusion:Significant right ventricular global longitudinal strain reduction starts as early as 24 hours after transcatheter closure, irrespective of the device size used. The rapid impact of closure was mainly on the biventricular basal and lateral segments and right ventricular apical ones, especially with the large sized atrial septal defect.
Implementation of a novel vocal cord dysfunction management pathway using the consolidated framework for implementation research
Authors: Merlo Greg , Suna Jessica M , McIntosh Amy , Jardine Karen , Kenny Louise , Orchard Jennifer , Wilson Mary , Alphonso Nelson 
Published: August 2021

AbstractEvery year in Australia over a thousand children who are born with congenital heart disease require surgical intervention. Vocal cord dysfunction (VCD) can be an unavoidable and potentially devastating complication of surgery for congenital heart disease. Structured, multidisciplinary care pathways help to guide clinical care and reduce mortality and morbidity. An implementation study was conducted to embed a novel, multidisciplinary management pathway into practice using the consolidated framework for implementation research (CFIR). The goal of the pathway was to prepare children with postoperative vocal cord dysfunction to safely commence and transition to oral feeding. Education sessions to support pathway rollout were completed with clinical stakeholders. Other implementation strategies used included adaptation of the pre-procedural pathway to obtain consent, improving the process of identifying patients on the VCD pathway, and nominating a small team who were responsible for the ongoing monitoring of patients following recruitment. Implementation success was evaluated according to compliance with pathway defined management. Our study found that while there were several barriers to pathway adoption, implementation of the pathway was feasible despite pathway adaptations that were required in response to COVID-19.