bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic retrospective analysis of 10 cases of neuroendocrine tumors of the ovary: diagnosis, treatment and follow-up
Authors: Zhang Wei , Chang Shuzhen , Cai Mingbo , Feng Wenlong , Liu Liya , Li-ping HAN 
Published: July 2021

Abstract
Background

Neuroendocrine tumors of the ovary are uncommon malignant carcinomas with a poor prognosis. There are no standardized management guidelines because of lack of knowledge about these tumors. The objective of this study is to analyze the clinical manifestations, diagnosis and treatment of ovarian neuroendocrine tumors (ONETs).
Results

Median age at diagnosis was 38.4 years (range 20–58). The main clinical presentations were abdominal pain or a pelvic mass. Two patients underwent fertility-sparing surgery and the others underwent cytoreductive surgery. The finial diagnosis depended on postoperative histopathology. According to the staging standard of the International Federation of Gynecology and Obstetrics (FIGO), three patients had stage I disease, one stage II, and six patients had stage III disease. Eight patients received chemotherapy alone postoperatively, one was maintained with Olaparib after chemotherapy, and one received chemotherapy followed by radiotherapy. The follow-up time for patients raged from 10 to 48 months. One patient died, while the other 9 patients were in follow-up. Seven patients experienced tumor recurrence.
Conclusion

Ovarian neuroendocrine tumors are characterized by high malignancy, low incidence and poor prognosis. Histopathological analysis is considered the gold standard for diagnosis. Surgical resection may be the first choice of therapy, and adjuvant chemotherapy and possible radiotherapy may prolong the survival of some patients.
Brass products in the coronet excavated from a M2-numbered Sui-Tang-dynasty tomb situated in Kun Lun Company in Xi'an, Shaanxi
Authors: Shao Yanbing , Jiang Fengrui , Du Jingnan , Yang Junchang , Zhang Quanmin 
Published: July 2021

Abstract
In this study, the brass wires in the coronet excavated from M2 tomb in Xi'an, Shaanxi, dating back to Sui-Tang-dynasty were probed via portable X-ray fluorescence spectrometry (XRF) and scanning electron microscopy in combination with energy dispersive spectrometry (SEM-EDS) techniques. The wires were found to be composed of 83 wt% of copper, 12 wt% of zinc, and 3 wt% of tin. According to the metallographic analysis, the wires were formed by integral hot forging, and were then installed on the coronet after surface cold shaping, via cutting and hammering during the production of the support parts. It indicated that the composition of brass was evenly distributed without obvious composition segregation, revealing the features of the second stage of brass smelting in ancient China, which may prove brass had appeared and brass smelting technology had been mastered in the Sui-Tang-dynasty in the Central Plains of China. In addition, the use of brass in the coronet was in accorded with the hierarchical symbol given to the material by the feudal society. And the selection of brass was based on the dual combination of the excellent mechanical properties and the golden surface of brass. Thus, brass in the Sui-Tang-dynasty historical period was the tangible evidence of the development level of metallurgical technology, and also reflected the artistic and social attributes given to materials by different stages of social development.
Chemical composition and vasodilator activity of different Alpinia zerumbet leave extracts, a potential source of bioactive flavonoids
Authors: Silva Munyck Almeida da , de Carvalho Lenize C. R. M. , Victório Cristiane P. , Ognibene Dayane , Resende Angela C. , de Souza Marcelo Vieira 
Published: July 2021

Abstract
A polyphenol-rich extract with an expressive vasodilator effect was obtained from fresh leaves of Alpinia zerumbet (AZ), a medicinal plant. The vasodilator effects of AZ obtained from different extraction conditions were studied in perfused mesenteric vascular bed, and total polyphenol content (TPC) was determined for all samples. Chemical composition of AZ was analyzed by UHPLC/ESI-QTOF-MS, and a list of putative compounds was obtained by a molecular network. Briefly, results obtained indicate a 50% hydroethanolic extract from fresh leaves (AZE4) as the best extraction condition, presenting the greatest vasodilator effect (ED 50 = 7.1 µg ± 1.73) and TPC (16.30 mg GAE/g ± 0.44). Flavonoids were detected as main constituents and alpinetin, kaempferol-3-O-glucuronide, (-)- epicatechin and pinocembrin were identified as major compounds. The last effective extraction condition was 50% hydroethanolic extract from dried leaves without heating, which showed the smallest vasodilator response (ED 50 = 29.1 µg ± 4.3) and TPC (6.35 mg GAE/g ± 0.08), reinforcing the use of fresh leaves and heating step to improve extracts performance. The vasodilator effect and the main flavonoid composition of AZE4 provide experimental support for the indication of this extract as a potential source of bioactive flavonoids for the treatment of cardiovascular diseases.
Analysis of Regulatory T-cells-specific mRNAs for Improving Prognosis, Immunotherapy Response and Therapeutic Resistance of Patients With Prostate Cancer
Authors: Ju Mingyi , Fan Jingyi , Zou Yuanjiang , Yu Mingjie , Jiang Longyang , Wei Qian , Bi Jia , Hu Baohui , Wang Lin , Guan Qiutong , Song Xinyue , Dong Mingyan , Yu Lifeng , Wang Yan , Wei Minjie , Kang Hui , Xin Wei , Zhao Lin 
Published: July 2021

Abstract
Background: Prostate cancer recognized as a “cold” tumor has an immunosuppressive microenvironment in which regulatory T-cells (Tregs) usually represent a major role. Therefore, identifying a prognostic signature of Tregs has promising benefits of improving survival of prostate cancer patients. However, the prognostic signature based on Tregs-specific mRNAs for prostate cancer is lacking. Methods: We systematicly analyzed transcriptional profiles of Tregs and 19 other immune cell types using 42 purified immune cell datasets from GEO to identify Tregs-specific mRNAs, and develop and validate a prognostic signature of Tregs (named “TILTregSig”) for monitoring prognosis of prostate cancer using TCGA and ICGC datasets. We also applied the signature to five immunotherapy response datasets and GSCALite to analyze the potential of the TILTregSig for predicting CIT response and cancer therapeutic resistance.Results: We develop the TILTregSig comprising five mRNAs (SOCS2, EGR1, RRM2, TPP1 and C11orf54) for prostate cancer patients. We find that the TILTregSig is a stronger predictor for tumor immunity compared with tumor mutation burden (TMB) and glycolytic activity which have been reported as immune predictors. Further analyses indicate that the TILTregSig may influence tumor immunity mainly by mediating tumor-infiltrating Tregs. Moreover, the TILTregSig also shows promising potential for predicting cancer immunotherapy (CIT) response and therapeutic resistance in multiple cancers.Conclusions: Our study has highlighted the value of the TILTregSig as a prognostic biomarker of prostate cancer from a tumor-infiltrating Tregs perspective, and strengthened its potential application as predictor of CIT response and cancer therapeutic resistance, which warrants further.
Cezanne enhances epithelial mesenchymal transition and prevents anthracycline-induced apoptosis via AKT/mTOR signaling in hepatocellular carcinoma
Authors: Zhong Xiao-Ping , Wang Jiahong , Mei Jie , Lu Lianghe , Ling Yihong , Li Shaohua , Tang Shijie , Kan Anna , Guo Rong-ping 
Published: July 2021

Abstract
Background

Anthracycline resistance have hindered the efficacy of transcatheter arterial chemoembolization (TACE). Translational research is therefore in need to find potential combinations by studying the resistance mechanism of anthracycline. In our published work, we found Cezanne could predict the efficacy of adjuvant TACE (ad-TACE) and induce epithelium mesenchymal transition (EMT) in hepatocellular carcinoma (HCC). We hereby conduct a sequential investigation to reveal the role of Cezanne on EMT and its potential to retard resistance.
Methods

The response of Cezanne in patients treated with adjuvant TACE after hepatectomy was evaluated. Functional assays were used to examine the resistance function of Cezanne to anthracyclin. In-situ tumorigenesis models and intraperitoneal perfusion chemotherapy experiment were used for in vivo verification.
Results

High expression of Cezanne correlated to a better outcome. Multivariate analysis showed low expression of Cezanne and the application of postoperative ad-TACE therapy were independent prognostic risk factors. However, patient outcome was significantly shorter in high Cezanne group of ad-TACE patients. In vitro assays revealed that HCC functions were inhibited after overexpressing Cezanne (OE-Cezanne). After treated with epirubicin, however, OE-Cezanne cell lines did not respond to treatment. In vivo experiment was consistent with in vitro assays. Besides, high Cezanne transforms cell morphology and is correlated to the activation of EMT related genes. Gene set analysis showed that Cezanne can regulate PI3K/AKT/mTOR signaling pathway. Therefore, mTOR inhibitor Rapamycin can reverse the resisting effect of Cezanne on HCC cell lines.
Conclusions

Adjuvant anthracycline-based TACE treatment after curative surgery can reduce the recurrence rate in HCC patients. However, in patients with high Cezanne expression, the efficacy of TACE may be undermined by EMT inducement. We discovered Cezanne modulates EMT by activating the AKT/mTOR signaling pathway and provided evidence for the rationale of combining mTOR inhibitor with TACE to prevent recurrence in HCC patients.
A Visual Analytics Framework from Geological Modeling to Reservoir Simulation
Authors: Hu Die , Cartwright Stephen , Lei Zhengdong , Hui Gang , Samoil Steven , Chen Zhangxin 
Published: July 2021

Abstract
Immersive technologies such as virtual reality has shown great potential in to enhance many important workflows the oil and gas industry. Immersive technologies have many natural advantages. These include enhanced spatial perception of 3D data, spatial user interfaces and interactions, the ability to provide collaboration space and incorporate analysis techniques. To take advantage of these technologies in the reservoir engineering domain, a visual analytics framework is established to demonstrate how these technologies may be used effectively. This framework allows a user to progress from geological modeling to reservoir simulation in an interactive and highly effective application. First, geological uncertainty analysis is conducted to screen representative realizations as candidates for simulation. Visualization and analysis of these representative realizations may then be performed in virtual reality using reservoir connectivity analysis of a tight oil reservoir. This application supports natural interactions, improved working space, and effective perception of underground connectivity. For this reason, it is more convenient and natural to work between a reservoir scale model and a set of candidate local realizations. This platform provides a basis for future data analysis methods and ways of interacting and visualizing data that support this analysis.
Spatial Variability of Soil Moisture in Mining Subsidence Area of Northwest China
Authors: lu bai , yajing wang , Zhang Kai , kaikai bao , jiangang zhao , xiaonan li 
Published: July 2021

Abstract
The current research only investigate the impact of coal mining on deep soil moisture from the perspective of the absolute value of soil moisture. This study applied the combined method of classical statistics and multi-dimensional geo-statistics to analyze the changes of soil moisture of time and space from 0-10m in the mining face of Nalin River No.2 Mine in Northwest China from the perspective of spatial variability. The results of the study showed that in time distribution, on the whole, the soil moisture in the partial areas of the 1-year and the 2-year subsidence area was lower than that in the control area, and the variability increased, but as the subsidence entered a stable period, the degree of variability decreased; vertically observed, in space distribution, the 0-10m soil moisture in the control area had obvious distribution rules with low spatial variability. However, the spatial variability of soil moisture in the 1-year subsidence area and the 2-year subsidence area increased, and the variability showed a trend of increasing continuously with the increase of depth. During the principal component analysis, it was found that the change of soil texture caused by coal mining subsidence, the change of microstructure of soil pores caused by geotechnical deformation, as well as the preferential flow caused by changes in groundwater level were the main reasons for the increasing spatial variability of soil moisture. This study revealed the principals of spatial variability of soil moisture in coal mining subsidence areas in Northwest China, which can provide a scientific basis for the restoration of mining areas.
Crystalline and magnetic properties of CoO nanoparticles locally investigated by using radioactive indium tracer
Authors: Santos Renata , Cabrera-Pasca Gabriel , Costa Cledilane , Santos Brianna , Otubo Larissa , Pereira Luciano , Correa Bruno , Effenberger Fernando , Burimova Anastasia , Freitas Rafael , Carbonari Artur 
Published: July 2021

Abstract
We herein report a comprehensive investigation on the magnetic, structural, and electric properties of CoO nanoparticles with different sizes by local inspection through hyperfine interactions measured in a wide range of temperatures (10-670 K) by using radioactive 111In( 111Cd) tracers with the perturbed angular correlations (PAC) technique. Small cobalt oxide nanoparticles with 6.5 nm have been prepared by the wet chemical route, which has shown essential to incorporate radioactivity tracers during nucleation and grown syntheses. Nanocrystalline samples with 22 nm size were obtained by thermal treatments under low pressure of helium at 670 K. The hyperfine data were correlated with X-ray diffraction (XRD), ZFC-FC magnetic measurements and transmission electron microscopy (TEM) to describe the structure, magnetic properties, size, and shape of samples. An analysis of the temperature evolution of hyperfine parameters revealed that the structural distortion and the magnetic disorder in the core and on the surface layer play an important role in the magnetic behavior of CoO nanoparticles.
Integrated Western and Chinese Medicine Interventions for Atopic Dermatitis: A Systematic Review and Meta-analysis
Authors: Sum Chi Him , Ching Jessica , Zhang Hong-Wei , Loo Steven , Lo Cho Wing , Lai Mei Kwan , Cheong Pui Kuan , Yu Chau Leung , Lin Zhixiu 
Published: July 2021

Abstract
BackgroundAtopic Dermatitis (AD) is a chronic relapsing skin disease characterized by recurring episodes of itchiness with skin erythema and surface damages. Chinese medicine (CM) is widely used for the management of AD in China not only by its own, but also used in combination with conventional therapy (integrated Western-Chinese medicine, ICWM) in China. Although many clinical trials on the effectiveness of ICWM on AD have been reported; however, up to date, no sound evidence has been established on the clinical effectiveness and safety of ICWM for AD. ObjectivesTo systematically review the currently available clinical evidence on the clinical effectiveness and safety of ICWM for AD. MethodsRandomized and quasi-randomized controlled trials, which investigated ICWM interventions with at least one control group using the same conventional interventions, no treatment or placebo treatment, were included. Four English (CENTRAL, MEDLINE, EMBASE, AMED) and three Chinese (CNKI, CBM, WanFang Med) databases were searched. Risk of bias was assessed according to the Cochrane’s tool. Meta-analysis were performed to pool the data. ResultsFrom 1473 database entries, 55 studies were included, of which 5953 participants aged between 35 days to 67 years old were involved. Duration of treatment ranged from 1 to 24 weeks. Only 2 studies were judged to be at low risk of bias, 3 studies at unclear risk of bias, and the other 50 studies at high risk of bias. The research findings suggested that ICWM was superior over WM alone in improving clinical severity of AD (measured by EASI, SCORAD), health-related quality of life (measured by CDLQI, DLQI), long term control of AD (recurrence rate), patients/ investigator global score (effectiveness rate), and serum IgE level. No more adverse events associated with ICWM was found when compared with WM alone. ConclusionAdopting ICWM may be superior to using WM alone in managing AD without risk of more adverse events. However, the current available evidence is still too weak to generate conclusive results.
GA-BP Neural Network Regression Model for Predicting the Soil Moisture of Ecological Slope Protection
Authors: Liu Dunwen , Liu Chao , Tang Yu , Gong Chun 
Published: July 2021

Abstract

The neural network optimized by genetic algorithm(GA) is an efficient and accurate prediction method, which can quickly find the optimal solution through high-speed computing capability and self-learning function. The neural network model optimized by GA is applied to the prediction of soil moisture of ecological slope protection, which provides reference for practical application of slope vegetation screening. In this paper, nine meteorological factors and soil moisture data were obtained by field monitoring instruments and related meteorological data. Considering the lag of meteorological factors, the neural network optimized by GA is used to predict the soil moisture of 8 meteorological data. The results show that the root mean square error (RMSE) and the mean absolute percentage error (MAPE) of the prediction model are 0.22726 and 0.41234%, respectively, indicating that the prediction model runs well. Through V-fold cross-validation, it is found that the prediction results of the model is accurate and stable. The algorithm combining artificial neural network and GA can well predict the soil moisture of ecological slope protection, with high prediction accuracy, and has a good application prospect in other fields.
BRCA1/2 Mutation Testing Among Adult Women With HER2-Negative Advanced Breast Cancer: Results From a Multi-Country, Real-World Study
Authors: Lux Michael Patrick , Lewis Katie , Rider Alex , Niyazov Alexander 
Published: July 2021

Abstract
Purpose: We assessed real-world patient demographics and breast cancer susceptibility genes 1 or 2 (BRCA1/2) mutation testing rates among adult women with human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer (ABC). Methods: Oncologists across the US and EU5 abstracted data from medical charts for 8–10 consecutive adult women presenting with HER2-negative ABC in 2015 and 2017. BRCA1/2 mutation (germline and/or somatic) testing was analysed overall and stratified by factors: region; year of data collection; hormone receptor (HR) status; age group; practice setting.Results: Records on 6161 adult women with HER2-negative ABC were provided by 742 oncologists. Overall, 28% of women with ABC received BRCA1/2 mutation testing. Compared with patients tested for BRCA1/2 mutations, untested patients were more likely to be aged ≥45 years, have HR-positive/HER2-negative ABC, have no known family history of breast/ovarian cancer, and be postmenopausal (all P < 0.0001). BRCA1/2 mutation testing rates were significantly lower in the EU5 versus US (21% vs 50%; P < 0.0001). Significantly lower BRCA1/2 testing rates were observed in women aged ≥45 versus <45 years, women without versus with a known family history of breast/ovarian cancer and women with HR-positive/HER2-negative ABC versus advanced TNBC (all P < 0.0001).Conclusions: BRCA1/2 mutation testing rates were low, and disparities were observed in demographics and clinical characteristics among patients who received a BRCA1/2 mutation test versus untested patients. Consistent with updated international guidelines, opportunities exist to increase BRCA1/2 mutation testing, particularly in patients aged ≥45 years, with HR-positive/HER2-negative ABC, or without a known family history of breast/ovarian cancer.
Minute-Ventilation Variability During Cardiopulmonary Exercise Test Is Higher In Idiopathic Dyspnoea Subjects Compared To Subjects With Breathing Pattern Disorder.
Authors: Eaton Andrew 
Published: July 2021

Abstract
Background: Patients with abnormal breathing responses often report presenting with debilitating symptoms that negatively impact both physical and mental quality of life.Objective: To compare time-domain variability of ventilatory components of Idiopathic dyspnoea and Breathing Pattern Disorder during a progressive maximal exercise test, evaluating their relationship to other variables usually obtained during a cardiopulmonary exercise test.Methods: Analysis of time-domain variability (RMSSD) of minute-ventilation (VE) during a maximal cardiopulmonary exercise test of 13 subjects with Idiopathic dyspnoea and 13 subjects with dysfunctional breathing pattern. Data was compared by a two-tailed Student T-test.Results: Idiopathic dyspnoea subjects exhibited a greater Minute-Ventilation Variability (31.5 ± 6.2 Vs 25.4 l/min ± 8.0, p >0.05). Inspiratory tidal volume time ratio (VTin/ti) (1.96 ± 0.7 Vs 2.58 ± 0.6, p >0.05) and Breathing Frequency (35 ± 9.3 Vs 43 breath/min ± 8.2 p >0.05) were also significantly lower in Idiopathic Dyspnoea compared to Breathing Pattern Disorder subjects.Conclusions: Time-domain variability of minute ventilation during exercise is greater in Idiopathic Dyspnoea compared to the Breathing Pattern Disorder subject’s possible highlighting a lower ventilatory threshold.