bluuebunny/crossref_metadata_2025_split huggingface dataset:
The acetabular roof reinforcement plate for the treatment of displaced acetabular fractures in the elderly: results in 59 patients
Authors: Krappinger Dietmar , Resch Herbert , Lindtner Richard A. , Becker Johannes , Mitterer Marian , Freude Thomas 
Published: April 2021

Abstract
Introduction
Open reduction and internal fixation is considered the gold standard of treatment for displaced acetabular fractures in younger patients. For elderly patients with osteoporotic bone quality, however, primary total hip arthroplasty (THA) with the advantage of immediate postoperative mobilization might be an option. The purpose of this study was to evaluate the clinical and radiological outcomes of surgical treatment of displaced osteoporotic acetabular fractures using the acetabular roof reinforcement plate (ARRP) combined with THA.

Materials and methods
Between 2009 and 2019, 84 patients were operated using the ARRP combined with THA. Inclusion criteria were displaced osteoporotic fractures of the acetabulum with or without previous hemi- or total hip arthroplasty, age above 65 years, and pre-injury ability to walk at least with use of a walking frame. Of the 84 patients, 59 could be followed up after 6 months clinically and radiographically. Forty-nine (83%) were primary fractures and 10 (17%) periprosthetic acetabular fractures.

Results
The mean age was 80.5 years (range 65–98 years). The average time from injury to surgery was 8.5 days (range 1–28). Mean time of surgery was 167 min (range 100–303 min). Immediate postoperative full weight bearing (FWB) was allowed for 51 patients (86%). At the 6-month follow-up, all 59 patients except one showed bony healing and incorporation of the ARRP. One case developed a non-union of the anterior column. No disruption, breakage or loosening of the ARRP was seen. Additional CT scans performed in 18 patients confirmed bony healing. Twenty-six patients (44%) had regained their pre-injury level of mobility. Complications requiring revision surgery occurred in 8 patients. Five of them were suffering from a prosthetic head dislocation, one from infection, one from hematoma and one from a heterotopic ossification.

Conclusions
The ARRP has proven to provide sufficient primary stability to allow for immediate FWB in most cases and represents a valuable option for the surgical management of displaced acetabular fractures in this challenging patient group.
The epicondylar ratio can be reliably determined in both computed tomography and X-ray
Authors: Lutz Bernd , Polcikova Lucia , Faschingbauer Martin , Reichel Heiko , Bieger Ralf 
Published: April 2021

AbstractPurposeOne of the key factors to the successful revision of total knee arthroplasty (rTKA) is the reconstruction of the joint line, which can be determined using the epicondylar ratio (ER). The measurement is established in X-ray and MRI. However, it is not known whether computed tomography (CT) allows a more reliable determination. The objective was to assess the reliability of the ER in CT and to determine the correlation between the ER in CT and a.p. X-ray of the knee.MethodsThe ER was determined on X-ray and CT images of a consecutive series of 107 patients, who underwent rTKA. Measurements were made by two blinded observes, one measured twice. The inter- and intraobserver agreement, as well as the correlation between the two methods, were quantified with the Intraclass Correlation Coefficient.ResultsThe average lateral ER was 0.32 (± 0.04) in X-ray and 0.32 (± 0.04) in CT. On the medial side, the average ER was 0.34 (± 0.04) in X-ray and 0.35 (± 0.04) in CT. The interobserver agreement for the same imaging modality was lateral 0.81 and medial 0.81 in X-ray as well as lateral 0.74 and medial 0.85 in CT. The correlation between the two methods was lateral 0.81 and medial 0.79.ConclusionsThe ER can be reliably determined in X-ray and CT. Measurements of the two image modalities correlate. Prior to rTKA, the sole use of the X-ray is possible.
Pregnancy outcomes in women with a hemoglobinopathy trait: a multicenter, retrospective study
Authors: Kasparek Jan , Burkhardt Tilo , Hoesli Irene , Amstad Bencaiova Gabriela 
Published: April 2021

Abstract
Purpose
To determine the risk of adverse maternal and neonatal outcomes in pregnant women with a hemoglobinopathy trait.

Materials and methods
Retrospective cohort study was conducted to compare adverse maternal and neonatal outcomes between pregnant women with a hemoglobinopathy trait (study group; n = 172), and without a hemoglobinopathy trait (control group; n = 360). The medical data were extracted from clinical records of pregnant women attending antenatal care and delivering at the University Hospital Basel or University Hospital Zurich between 2015 and 2018.

Results
A total of 172 pregnant women with a hemoglobinopathy trait and 360 controls were recruited. Apart from fetal acidosis, the groups did not differ significantly in any variables of adverse neonatal outcomes. Whereas, among the maternal outcomes the rate of abortion, gestational diabetes mellitus, bacteriuria or urinary tract infection, intrahepatic cholestasis, abnormal placentation and anemia postpartum were significantly increased in women with a hemoglobinopathy trait.

Conclusion
In our study, a hemoglobinopathy trait increased the risk of adverse maternal outcomes but did not increase adverse neonatal outcomes.
Osteoid osteoma: which is the best mininvasive treatment option?
Authors: Parmeggiani Anna , Martella Claudia , Ceccarelli Luca , Miceli Marco , Spinnato Paolo , Facchini Giancarlo 
Published: April 2021

AbstractOsteoid osteoma is the third most common benign bone tumor, with well-known clinical presentation and radiological features. Although surgical excision has been the only therapeutic option for a long time, to date it has been replaced by minimally invasive techniques, which proved satisfactory success rates and low complication occurrence. Therefore, the purpose of this literature review was to describe the main updates of these recent procedures in the field of interventional radiology, with particular attention paid to the results of the leading studies relating to the efficacy, complications, and recurrence rate. Nevertheless, this study aimed to analyze the peculiarities of each reported technique, with specific focus on the possible improvements and pitfalls. Results proved that all mininvasive procedures boast a high success rate with slight number of complications and a low recurrence rate. Radiofrequency ablation is still considered the gold standard procedure for percutaneous treatment of osteoid osteoma, and it has the possibility to combine treatment with a biopsy. Interstitial laser ablation’s advantages are the simplicity of use and a lower cost of the electrodes, while cryoablation allows real-time visualization of the ablated zone, increasing the treatment safety. Magnetic resonance-guided focused ultrasound surgery is the most innovative non-invasive procedure, with the unquestionable advantage to be radiation free.
The evolution of hierarchical structure building capacity for language and music: a bottom-up perspective
Authors: Asano Rie 
Published: April 2021

AbstractA central property of human language is its hierarchical structure. Humans can flexibly combine elements to build a hierarchical structure expressing rich semantics. A hierarchical structure is also considered as playing a key role in many other human cognitive domains. In music, auditory-motor events are combined into hierarchical pitch and/or rhythm structure expressing affect. How did such a hierarchical structure building capacity evolve? This paper investigates this question from a bottom-up perspective based on a set of action-related components as a shared basis underlying cognitive capacities of nonhuman primates and humans. Especially, I argue that the evolution of hierarchical structure building capacity for language and music is tractable for comparative evolutionary study once we focus on the gradual elaboration of shared brain architecture: the cortico-basal ganglia-thalamocortical circuits for hierarchical control of goal-directed action and the dorsal pathways for hierarchical internal models. I suggest that this gradual elaboration of the action-related brain architecture in the context of vocal control and tool-making went hand in hand with amplification of working memory, and made the brain ready for hierarchical structure building in language and music.
Evaluation of an enrichment programme for a colony of long-tailed macaques (Macaca fascicularis) in a rescue centre
Authors: Albanese Valeria , Kuan Michela , Accorsi Pier Attilio , Berardi Roberta , Marliani Giovanna 
Published: April 2021

AbstractLong-tailed macaques are highly social primates that are commonly used in biomedical research as animal models. The aim of this study was to evaluate the effects of different kinds of enrichment on the behaviour and faecal cortisol metabolite (FCM) level in a colony of ex-laboratory long-tailed macaques during a programme of rehabilitation. The research was carried out in three periods, divided into two sessions each. Every period was composed of one control session (SC) and one session characterised by one type of enrichment: feeding enrichment (FE), manipulative enrichment (ME), and the last session during which manipulative and feeding enrichment were provided every day but in a mixed way (MIX). The results showed that manipulative and mixed enrichments caused positive changes to the activity budget of the colony, with a decrease in abnormal behaviour rates and an increase in play compared with control sessions. The rate of affiliative behaviours and low rate of aggression were probably because the group was composed mostly of females and it was stable, with a well-defined hierarchy. The research underlines the importance of a well-studied enrichment programme for the welfare of captive animals, which should exploit species-specific motivations.
Effects of invasive wetland macrophytes on habitat selection and movement by freshwater turtles
Authors: Angoh Siow Yan Jennifer , Freeland Joanna , Paterson James , Rupasinghe Prabha Amali , Davy Christina M. 
Published: April 2021

AbstractInvasive species can significantly impact native wildlife by structurally altering habitats and access to resources. Understanding how native species respond to habitat modification by invasive species can inform effective habitat restoration, avoiding inadvertent harm to species at risk. The invasive graminoids Phragmites australis australis (hereafter Phragmites) and Typha ×  glauca are increasingly dominating Nearctic wetlands, often outcompeting native vegetation. Previous research suggests that turtles may avoid invasive Phragmites when moving through their home ranges, but the mechanisms driving avoidance are unclear. We tested two hypotheses that could explain avoidance of invaded habitat: (1) that stands of invasive macrophytes (Phragmites and Typha x glauca) impede movement, and (2) that they provide inadequate thermal conditions for turtles. We quantified active-season movements of E. blandingii (n = 14, 1328 relocations) and spotted turtles (Clemmys guttata; n = 12, 2295 relocations) in a coastal wetland in the Laurentian Great Lakes. Neither hypothesis was supported by the data. Phragmites and mixed-species Typha stands occurred within the home ranges of mature, active E. blandingii and C. guttata, and were used similarly to most other available habitats, regardless of macrophyte stem density. Turtles using stands of invasive macrophytes did not experience restricted movements or cooler shell temperatures compared to other wetland habitat types. Control of invasive macrophytes can restore habitat heterogeneity and benefit native wetland species. However, such restoration work should be informed by the presence of at-risk turtles, as heavy machinery used for control or removal may injure turtles that use these stands as habitat.
$$\ell _{1}$$ Common Trend Filtering
Authors: Yamada Hiroshi , Bao Ruoyi 
Published: April 2021

AbstractThe$$\ell _{1}$$ℓ1trend filtering enables us to estimate a continuous piecewise linear trend of univariate time series. This filter and its variants have subsequently been applied in various fields, including astronomy, climatology, economics, electronics, environmental science, finance, and geophysics. Although the$$\ell _{1}$$ℓ1trend filtering can estimate a continuous piecewise linear trend of univariate time series, it cannot estimate a common continuous piecewise linear trend of multiple time series. This paper develops a statistical procedure that enables us to estimate it, which is a multivariate extension of the$$\ell _{1}$$ℓ1trend filtering. We provide an algorithm for estimating it and a clue to specify the tuning parameter of the procedure, both required for its application. We also (i) numerically illustrate how well the algorithm works, (ii) provide an empirical illustration, and (iii) introduce a generalization of our novel method.
Streaming changepoint detection for transition matrices
Authors: Plasse Joshua , Hoeltgebaum Henrique , Adams Niall M. 
Published: April 2021

AbstractSequentially detecting multiple changepoints in a data stream is a challenging task. Difficulties relate to both computational and statistical aspects, and in the latter, specifying control parameters is a particular problem. Choosing control parameters typically relies on unrealistic assumptions, such as the distributions generating the data, and their parameters, being known. This is implausible in the streaming paradigm, where several changepoints will exist. Further, current literature is mostly concerned with streams of continuous-valued observations, and focuses on detecting a single changepoint. There is a dearth of literature dedicated to detecting multiple changepoints in transition matrices, which arise from a sequence of discrete states. This paper makes the following contributions: a complete framework is developed for adaptively and sequentially estimating a Markov transition matrix in the streaming data setting. A change detection method is then developed, using a novel moment matching technique, which can effectively monitor for multiple changepoints in a transition matrix. This adaptive detection and estimation procedure for transition matrices, referred to as ADEPT-M, is compared to several change detectors on synthetic data streams, and is implemented on two real-world data streams – one consisting of over nine million HTTP web requests, and the other being a well-studied electricity market data set.
The impact of artisanal gold mining, ore processing and mineralization on water quality in Marmato, Colombia
Authors: Torrance Keith W. , Redwood Stewart D. , Cecchi Alessandro 
Published: April 2021

AbstractMarmato, Colombia, has been an important centre of gold mining since before the first Spanish colonizers arrived in 1536. The Marmato deposit is hosted in a dacite and andesite porphyry stock as sheeted sulphide-rich veinlet systems. The district is currently experiencing a surge in both major mining projects and artisanal mining, driven by sustained high gold prices. Ore from small-scale and artisanal gold mining is processed in numerous small mills (entables) around Marmato, which impact surface water quality through the discharge of milled waste rock slurry, highly alkaline cyanide-treated effluent, and high dissolved metal loads. To investigate the impact of artisanal mining and ore processing, water samples were collected in January 2012 from streams around Marmato. The average dissolved metal concentrations in impacted streams were Zn, 78 mg L−1; Pb, 0.43 mg L−1; Cu, 403 µg L−1 Cd, 255 µg L−1; As, 235 µg L−1; Ni, 67 µg L−1; Co, 55 µg L−1; Sb, 7 µg L−1; and Hg, 42 ng L−1, exceeding World Health Organization drinking water guidelines. In addition, arsenic speciation was conducted in-situ and indicated that 91–95% of inorganic arsenic species is in the form of As(V). Spatial analysis of the data suggests that entables processing ore for artisanal miners are the main contributor to water pollution, with high sediment loads, alkalinity and elevated concentrations of dissolved arsenic, cadmium, mercury and lead, caused by the processing of gold-bearing sulphides in the entables. Geochemical data from surface water were compared to a comprehensive data set of whole rock analyses from drill core and channel samples from the deposit, indicating that the deposit is significantly enriched in gold, silver, lead, zinc, arsenic, antimony, and cadmium compared to crustal averages, which is reflected in the surface water geochemistry. However, elevated mercury levels in surface water cannot be explained by enrichment of mercury in the deposit and strongly suggest that mercury is being added to concentrates during ore processing to amalgamate fine gold.
Intermittent levosimendan infusion in ambulatory patients with end-stage heart failure: a systematic review and meta-analysis of 984 patients
Authors: Elsherbini Hagar , Soliman Osama , Zijderhand Casper , Lenzen Mattie , Hoeks Sanne E. , Kaddoura Rasha , Izham Mohamed , Alkhulaifi Abdulaziz , Omar Amr S. , Caliskan Kadir 
Published: April 2021

Abstract
We sought to synthesize the available evidence regarding safety and efficacy of intermittent levosimendan (LEVO) infusions in ambulatory patients with end-stage heart failure (HF). Safety and efficacy of ambulatory intermittent LEVO infusion in patients with end-stage HF are yet not established. We systematically searched MEDLINE, EMBASE, SCOPUS, Web of Science, and Cochrane databases, from inception to January 30, 2021 for studies reporting outcome of adult ambulatory patients with end-stage HF treated with intermittent LEVO infusion. Fifteen studies (8 randomized and 7 observational) comprised 984 patients (LEVO [N = 727] and controls [N = 257]) met the inclusion criteria. LEVO was associated with improved New York Heart Association (NYHA) functional class (weighted mean difference [WMD] −1.04, 95%CI: −1.70 to −0.38, p < 0.001, 5 studies, I2 = 93%), improved left ventricular (LV) ejection fraction (WMD 4.0%, 95%CI: 2.8% to 5.3%, p < 0.001, 6 studies, I2 = 9%), and reduced BNP levels (WMD −549 pg/mL, 95%CI −866 to −233, p < 0001, 3 studies, I2 = 66%). All-cause death was not different (RR 0.65, 95%CI: 0.38 to 1.093, p = 0.10, 6 studies, I2 = 0), but cardiovascular death was lower on LEVO (RR 0.34, 95%CI: 0.13 to 0.87, p = 0.02, 3 studies, I2 = 0) compared to controls. Furthermore, health-related quality of life (HRQoL) was improved alongside with reduced LV size following LEVO infusions. Major adverse events were not different between LEVO and placebo. In conclusion, intermittent LEVO infusions in ambulatory patients with end-stage HF is associated with less frequent cardiovascular death alongside with improved NYHA class, quality of life, BNP levels, and LV function. However, the current evidence is limited by heterogeneous and relatively small studies.
Modelling the size, cost and health impacts of universal basic income: What can be done in advance of a trial?
Authors: Johnson Matthew Thomas , Johnson Elliott Aidan , Webber Laura , Friebel Rocco , Reed Howard Robert , Lansley Stewart , Wildman John 
Published: April 2021

AbstractOpposition to Universal Basic Income (UBI) is encapsulated by Martinelli’s claim that ‘an affordable basic income would be inadequate, and an adequate basic income would be unaffordable’. In this article, we present a model of health impact that transforms that assumption. We argue that UBI can affect higher level social determinants of health down to individual determinants of health and on to improvements in public health that lead to a number of economic returns on investment. Given that no trial has been designed and deployed with that impact in mind, we present a methodological framework for assessing prospective costs and returns on investment through modelling to make the case for that trial. We begin by outlining the pathways to health in our model of change in order to present criteria for establishing the size of transfer capable of promoting health. We then consider approaches to calculating cost in a UK context to estimate budgetary burdens that need to be met by the state. Next, we suggest means of modelling the prospective impact of UBI on health before asserting means of costing that impact, using a microsimulation approach. We then outline a set of fiscal options for funding any shortfall in returns. Finally, we suggest that fiscal strategy can be designed specifically with health impact in mind by modelling the impact of reform on health and feeding that data cyclically back into tax transfer module of the microsimulation.
Regularization of inverse problems by an approximate matrix-function technique
Authors: Cipolla Stefano , Donatelli Marco , Durastante Fabio 
Published: April 2021

AbstractIn this work, we introduce and investigate a class of matrix-free regularization techniques for discrete linear ill-posed problems based on the approximate computation of a special matrix-function. In order to produce a regularized solution, the proposed strategy employs a regular approximation of the Heavyside step function computed into a small Krylov subspace. This particular feature allows our proposal to be independent from the structure of the underlying matrix. If on the one hand, the use of the Heavyside step function prevents the amplification of the noise by suitably filtering the responsible components of the spectrum of the discretization matrix, on the other hand, it permits the correct reconstruction of the signal inverting the remaining part of the spectrum. Numerical tests on a gallery of standard benchmark problems are included to prove the efficacy of our approach even for problems affected by a high level of noise.
Selection of solar tracking system using extended TOPSIS technique with interval type-2 pythagorean fuzzy numbers
Authors: Umer Rimsha , Touqeer Muhammad , Omar Abdullah Hisam , Ahmadian Ali , Salahshour Soheil , Ferrara Massimiliano 
Published: April 2021

AbstractThe Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) is considered among the most frequently used techniques to deal with multi-criteria group decision-making (MCGDM) conflicts. In this article, we have presented an extended TOPSIS technique in the framework of interval type-2 trapezoidal Pythagorean fuzzy numbers (IT2TrPFN). We first projected a novel approach to evaluate the distance between them using ordered weighted averaging operator and $$(\alpha ,\beta )$$

(
α
,
β
)

-cut. Subsequently, we widen the concept of TOPSIS method formed on the distance method with IT2TrPFNs and applied it on MCGDM dilemma by considering the attitudes and perspectives of the decision-makers. Lastly, an application of solar tracking system and numerous contrasts with the other existing techniques are presented to express the practicality and feasibility of our projected approach.