bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paracelsus 10,000: A Prospective Cohort Study Based On The Population of Salzburg, Austria. Rationale, Objectives And Study Design
Authors: Frey Vanessa Natalie , Langthaler Patrick , Raphaelis Emanuel , Ring-Dimitriou Susanne , Kedenko Ludmilla , Aigner Elmar , Martinz Jennifer , Gostner Isabella , Bathke Arne , Fartacek Reinhold , Sungler Paul , Ladurner Gunter , Studnicka Michael , Haschke-Becher Elisabeth , Trinka Eugen , Iglseder Bernhard , Paulweber Bernhard 
Published: August 2021

Abstract
Paracelsus 10,000 is a prospective cohort study with the objective to investigate the health status of the population in and around the city of Salzburg. The focus lies on common non-communicable diseases, mainly cardiovascular and cerebrovascular diseases, and their risk factors in a population-based cohort aged between 40 and 70 years. Between the years 2013 and 2020, 10,062 randomly selected participants (w: 5,187, m: 4,875) were investigated, of whom 2,620 underwent an intensified examination. The program consists not only of medical examinations, but was extended to inventories on mental disorders, lifestyle including nutrition and physical activity. From all study participants biological samples were stored in a biobank at -80°C enabling future investigations of biomarkers and utilization of the whole spectrum of multi-omics. The first follow-up phase of the study has started in late 2020 and will allow us to investigate the development of common non-communicable diseases occurring over time in the cohort of the Paracelsus 10,000 study. This gives the study a unique position within the framework of Austrian epidemiological research with the potential to gain new insight into the role of interaction between genetic predisposition and lifestyle factors for disease development in the Salzburg population. Obtaining high-quality epidemiological data is also of particular relevance for the development of evidence-based prevention strategies. This report describes rationale, objectives and design of the study and provides insight into the main characteristics of the study cohort.
Dietary Exposure To Thyroid Disrupting Chemicals: A Community-Based Study in Newfoundland (Canada)
Authors: Babichuk Nicole , Sarkar Atanu , Mulay Shree , Knight John , Randell Edward 
Published: August 2021

Abstract
The marine ecosystem around the Island of Newfoundland is contaminated by Thyroid Disrupting Chemicals (TDCs). Coastal inhabitants may be exposed to TDCs through consumption of contaminated local seafood products and affecting thyroid functions. The aim of this study was to explore: (1) consumption frequency of local seafood products consumed by rural residents, (2) thyroid hormones (THs) and TDCs concentrations in residents, (3) relationships between local seafood consumption, TDC concentrations, and THs. Participants (n = 80) were recruited from two rural Newfoundland communities. Seafood consumption was measured through a validated seafood consumption questionnaire. Blood samples were collected from all participants and tested for THs (thyroid stimulating hormone, free thyroxine, free triiodothyronine) and TDCs including polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), and dichlorodiphenyldichloroethylene (p,p’-DDE). Cod was the most frequently consumed local species, but there was a wide range of other local species consumed. Older participants (> 50 years) had greater plasma concentrations of PBB-153, PCBs and p,p’-DDE, and males had higher concentrations of all TDCs than females. The consumption frequency of local cod was found to be positively associated with several PCB congeners, p,p’-DDE and ∑14TDCs. There was no significant relationship between TDCs and THs in either simple or multivariate linear regression analyses.
Spectrally multiplexed and ultrabright entangled photon pairs in a lithium niobate microresonator
Authors: Xu Bo-Yu , Chen Li-Kun , Lin Jintian , Feng Lan-Tian , Niu Rui , Zhou Zhi-yuan , Gao Renhong , Dong Chun-Hua , Guo Guangcan , Gong Qihuang , Cheng Ya , Xiao Yun-Feng , Ren Xi-Feng 
Published: August 2021

Abstract
On-chip bright quantum sources with multiplexing ability are extremely high in demand for the integrated quantum networks with unprecedented scalability and complexity. Here, we demonstrate an ultrabright and broadband biphoton quantum source generated in a lithium niobate microresonator system. Without introducing the conventional domain poling, the on-chip microdisk produces entangled photon pairs covering a broad bandwidth promised by natural phase matching in spontaneous parametric down conversion. Experimentally, the multiplexed photon pairs are characterized by 30 nm bandwidth limited by the filtering system, which can be furthered enlarged. Meanwhile, the generation rate reaches 5.13 MHz/μW with a coincidence-to-
accidental ratio up to 804. Besides, the quantum source manifests the prominent purity with heralded single photon correlation g(2)H(0)=0.0098±0.0021 and energy-time entanglement with excellent interference visibility of 96.5%±1.9%.
Diagnostic Value of Oral “Beefy Red” Patch Combined with Fingertip Blood Mean Corpuscular Volume in Vitamin B12 Deficiency
Authors: Xu Xiaoheng , Liu Yang , Xiong Xiaoqin , Yao Yanmei , Hu Huiting , Jiang Xiao , Meng Wenxia 
Published: August 2021

Abstract
Objectives: To investigate the diagnostic value of accessible fingertip mean corpuscular volume (MCV) combined with a visible “beefy red” patch in the diagnosis of vitamin B12 (VB12) deficiency in local clinics and hospitals without in-house clinical laboratories, especially in remote areas.Materials and methods The medical history data of patients complaining of oral mucosal pain at the Stomatological Hospital of Southern Medical University were reviewed. All included patients underwent fingertip blood routine examination, specific serological test (serum VB12, folic acid, iron, and ferritin), and detailed oral clinical examinations. According to the results of the serum VB12 test patients were divided into case and control groups. The diagnostic value of the “beefy red” patch and elevated MCV in VB12 deficiency was evaluated by the receiver operator characteristic curve.Results There are more female patients in the case group (n=81) and the control group (n=60). Compared to the control group, the number of patients with “beefy red” patch and abnormal MCV increased significantly in the case group (P<0.05). The diagnostic test, “beefy red patch” has high sensitivity but low specificity, “MCV>100 fL” has high sensitivity but low specificity, and “MCV>100 fL combined with beefy red patch” has maximal specificity, and area under the curve.Conclusions Visible oral “beefy red” patch combined with accessible fingertip blood MCV could improve the rate of diagnosis in VB12 deficiency, especially in the elderly in local clinics and hospitals without in-house clinical laboratories in China, which is conducive to early disease detection and treatment.
Modeling of the Thermal Properties of SARS-CoV-2 S-protein
Authors: Song Meichen , Niu Ziyuan , Hasegawa Karin , Deng Yuefan , Rafailovich Miriam , Simon Marcia , Zhang Peng 
Published: August 2021

Abstract
We present the thermal and conformational states of the spike glycoprotein (S-protein) of SARS-CoV-2 at six temperatures ranging from 3℃ to 95℃ by all-atom molecular dynamics (MD) µs-scale simulations. While corroborating with clinical results of the temperature impact on the COVID-19 infection, we examine the potential phase transitions of the S-protein in the temperature range and our simulation results revealed the following thermal properties of the S-protein: (1) It is structurally stable at 3℃, agreeing with observations that the virus stays active for more than two weeks in the cold supply chain; (2) Its structure varies more significantly for temperature window of 60℃ to 80℃ than in all other windows; (3) The sharpest structural variations occur near 60℃, signaling a plausible critical temperature nearby; (4) The maximum deviation of the receptor-binding domain at 37°C suggests the anecdotal observation that the virus is most infective at 37°C; (5) The in silico data agree with reported experiments of the SARS-CoV-2 survival times from weeks to seconds by our clustering approach analysis.
Improving Adherence and Quality of Life of CPAP for Obstructive Sleep Apnea With An Intervention Based On Stratification and Personalization of Care Plans: A Randomized Controlled Trial
Authors: Rudilla David , Perelló Salvador , Landete Pedro , Zamora Enrique , Vázquez María , Sans Lluisa , Tomás Jose Manuel , Martín Jose Luis R , Leonardi Jennifer , Rubinos Gema , Ancochea Julio 
Published: August 2021

Abstract
Purpose

The aim was to determine adherence to CPAP and health-related outcomes in patients with OSA via a comprehensive program based on stratification and individualized care plans, including motivational interview.
Methods

A multicentre, randomized controlled trial (RCT) design was used in 3 hospitals. The control group followed the usual treatment. Intervention group (PIMA) followed the treatment with an adapted care plan (home visits, telephone, care-center) depending on socio-demographic, clinical and psychological variables, using motivational interviews in all the interventions. The main outcome was adherence, and secondary were quality of life, emotional state, activities, social relationships, perceived competence, and motivation. The clinical trial was registered with www.clinicaltrials.gov (NCT 04691479).
Results

213 patients (68.1% men, 58.7% between 51–69 years old, 45.5% upper-secondary school education) were randomized: 108 were in the intervention group and 105 were in the control group. The result showed a statistically significant difference in adherence at 90 and 180 days respectively: 129.24 (IC 95% 77.25-181.22) p < 0.0001 and 288.30 (IC95% 187.146–389.47) p < 0.0001. The adherence (hours/day) showed favourable results for the PIMA group compared to the control group at 90 days with a difference of 1.74 hours/day (IC95% 1.18–2.30) p < 0.0001 and at 180 days with a difference of 2.31 (IC95% 1.72–2.91) p < 0.001. The results for secondary outcomes also showed statistically significant differences in favour of the PIMA group.
Conclusions

This study found evidence that a program based on stratification and personalized care plans, through motivational interviewing, improves adherence to CPAP treatment and health-related outcomes than traditional care.
Nitrogen Fixation by Paenibacillus Polymyxa WLY78 is Responsible for Cucumber Growth Promotion
Authors: Liu Shuang , Li Qin , Li Yongbin , Hao Tianyi , Chen Sanfeng 
Published: August 2021

Abstract
Aims To study nitrogen contribution to cucumber derived from nitrogen fixation of Paenibacillus polymyxa WLY78.Methods The nif gene cluster deletion mutant (ΔnifB-V) of P. polymyxa WLY78 is constructed by a homologous recombination method. The GFP-labeled ΔnifB-V mutant was used to inoculate cucumber and to study colonization by confocal laser scanning microscope. The effects of plant-growth promotion were investigated by greenhouse experiments. The nitrogen fixation contribution was estimated by 15N isotope dilution experiments. Results Deletion of nif gene cluster of P. polymyxa WLY78 resulted in complete loss of nitrogenase activity. Observation by laser confocal microscopy revealed ΔnifB-V mutant can effectively colonize cucumber root, stem and leaf tissues, like wild-type P. polymyxa WLY78. Greenhouse experiments showed that inoculation with P. polymyxa WLY78 can significantly enhance the lengths and dry weights of cucumber roots and shoots, but inoculation with ΔnifB-V mutant can not. 15N isotope dilution experiments showed that cucumber plants derive 25.93% nitrogen from nitrogen fixation performed by P. polymyxa WLY78, but the ΔnifB-V mutant nearly can not provide nitrogen for plant growth. Conclusions This present study demonstrates that nitrogen fixation performed by P. polymyxa WLY78 is responsible for cucumber growth promotion.
Hydrophobic and Flame-Retardant Foam Based on Cellulose
Authors: Kader Amal H. Abdel , Dacrory sawsan , Khattab Tawfik A. , kamel samir , Abou-Yousef Hussein 
Published: August 2021

Abstract
A series of lightweight, hydrophobic, and fire retardant foams were fabricated through activation of cellulose by phosphoric acid as a primarily step. Dolomite clay was embedded onto the cellulosic suspensions with gelatin/ tannin as adhesive followed by freeze drying process. A solution of the environmentally friendly silicone rubber (RTV) was applied onto foam samples via spray-coating to improve their water repealing performance, which was explored by investigating both of water contacting angle and wettability time of the coated foam samples. Flammability characteristics, thermal decomposition, surface morphology, and chemical structure of treated and untreated foams were investigated by flammability test, thermogravimetric analysis, scanning electron microscopy, X-ray diffraction, and Fourier-transform infrared, respectively. Results showed that the foams loaded dolomite and coated RTV have high hydrophobicity as well as anti-inflammability.
Internal Resonance of Hyperelastic Thin-Walled Cylindrical Shells under Harmonic Axial Excitation and Time-Varying Temperature Field
Authors: Xu Jie , Xuegang Yuan , Zhang Hongwu , Ma Minfu , Zhao Wei 
Published: August 2021

Abstract
In this paper, the internal resonance characteristics of hyperelastic cylindrical shells under the time-varying temperature field are investigated for the first time, and the evolution of the isolated bubble is carried out. Through the analysis of the influences of temperature on material parameters, the hyperelastic strain energy density function in the unsteady temperature field is presented. The governing equations describing the axisymmetric nonlinear vibration are derived from the nonlinear thin shell theory and the variational principle. With the harmonic balance method and the arc length method, the steady state solutions of shells are obtained, and their stabilities are determined. The influences of the discrete mode number, structural and temperature parameters on the nonlinear behaviors are examined. The role of the parameter variation in evolution behaviors of isolated bubble responses is revealed under the condition of 3:1 internal resonance. The results manifest that both structural and temperature parameters can affect the resonance range of the response curve, and the perturbed temperature has a more significant effect on the stable region of the solution.
Bus Queue Time Estimation Model for a Curbside Bus Stop Considering the Blocking Effect
Authors: LUO Tian , LIU Xiaobin , JIN Hui 
Published: August 2021

Abstract
Bus queue time estimation of a curbside bus stop is essential to evaluate the operation, reliability and performance of a bus system. Arriving buses and served buses on upstream berths form an overflow queue considering the no overtaking principle and limited overtaking principle. Therefore, the bus dwelling time at the C-th berth may directly influence the stop capacity. The bus queue delay is modeled as a function of bus dwell time at the C-th berth and the dwell time at every berth using different distributions (normal and lognormal distributions) and data fitting approaches. This study aims to estimate the queue time attributed to dwell time at the C-th berth. The results indicate that the queue time should be evaluated by bus dwell time and joint probability density to quantify the negative influence on queue delay. Therefore, in some cases, where decisions must be taken into consideration for more than two buses, the relationship between dwell time at a downstream berth and dwell time at the C-th berth must be considered.
Bronchiectasis - Exercise as Therapy (BREATH): Rationale and Study Protocol for a Multi-center Randomized Controlled Trial
Authors: Jones Taryn , O’Grady Kerry-Ann F , Goyal Vikas , Masters Ian B , McCallum Gabrielle , Drovandi Christopher , Lung Thomas , Baque Emmah , Brookes Denise S K , Terranova Caroline O , Chang Anne B , Trost Stewart G 
Published: August 2021

Abstract
Background: Globally, bronchiectasis (BE) unrelated to cystic fibrosis (CF) is recognized as a major cause of respiratory morbidity, mortality and health-care utilization. Children with BE regularly experience exacerbations of their condition resulting in frequent hospitalizations and decreased health related quality of life (HRQoL). Guidelines for the treatment and management of BE call for regular exercise as it may reduce the incidence of acute exacerbations. To date, the short and long-term health benefits resulting from therapeutic exercise have not been investigated in children with BE. We aim to determine if a therapeutic exercise program is effective in reducing the proportion of children with BE who experience any exacerbation in a 12-month period. The secondary aims are to determine the cost-effectiveness of the intervention, and assess the program’s impact on aerobic fitness, fundamental movement skill (FMS) proficiency, habitual physical activity, HRQoL, and lung function.Methods: This multi-center, observer-blinded, parallel group (1:1 allocation), randomized controlled trial (RCT) will be conducted at three sites. One hundred and seventy-four children aged six to under 13 years with BE will be randomized to a developmentally appropriate, play-based therapeutic exercise program (eight, 60-minute weekly sessions, supplemented by a home-based program) or usual care. Randomization will be stratified by site. Outcome measures (aerobic fitness, fundamental movement skill proficiency, habitual physical activity, HRQoL, and lung function) will be assessed at baseline, 9 weeks, 6 and 12-months. Monthly, parental contact and medical review will document acute respiratory exacerbations and parameters for cost-effectiveness outcomes. Discussion: Results from this study will test the effects of the therapeutic exercise program to prevent acute exacerbations and improve FMS proficiency, fitness, and HRQoL in children with BE. The program could be readily translated with low cost equipment and flexible delivery and have the potential for a major paradigm shift in the way in which therapeutic exercise is prescribed and implemented in children with chronic respiratory conditions. This RCT is required because it will provide long overdue Level 1 evidence regarding the efficacy and cost-effectiveness of tailored therapeutic exercise programs for children with BE.Trial registration: Australian and New Zealand Clinical Trials Register (ANZCTR) number ACTRN12619001008112.
Viable Medical Waste Chain Network Design by Considering Risk and Robustness
Authors: Lotfi Reza , Kargar Bahareh , Gharehbaghi Alireza , Weber Gerhard-Wilhelm 
Published: August 2021

Abstract
Medical Waste Management (MWM) is an important and necessary problem in the COVID-19 situation for treatment staff. When the number of infectious patients grows up and amount of MWMs increases day by day. We present Medical Waste Chain Network Design (MWMCND) that contains Health Center (HC), Waste Segregation (WS), Waste Purchase Contractor (WPC) and landfill. We propose to locate WS to decrease waste and recover them and send them to the WPC. Recovering medical waste like metal and plastic can help the environment and return to the production cycle. Therefore, we proposed a novel Viable MWCND by a novel two-stage robust stochastic programming that considers resiliency (flexibility and network complexity) and sustainable (energy and environment) requirements. Therefore, we try to consider risks by Conditional Value at Risk (CVaR) and improve robustness and agility to demand fluctuation and network. We utilize and solve it by GAMS CPLEX solver. The results show that by increasing the conservative coefficient, the confidence level of CVaR and waste recovery coefficient increases cost function and population risk. Moreover, increasing demand and scale of the problem make to increase the cost function.
Development and validation of a 13-m6a related lncRNA prognostic signature for lung adenocarcinoma
Authors: Wu Pingfan , Zhao Xiaowen , Xue Ling , Yang Xiaojing , Shi Yuxiang , Wang Jingjing , Gao Chengying , She Yali , Li Yaling , Li Changtian 
Published: August 2021

Abstract
Considerable evidence suggests that N6-methyladenosine (m6A) is involved in the regulation of long non-coding RNA (lncRNA), whichparticipates in the occurrence, development and prognosis of tumorscancerBut the relationship between m6A regulators-related lncRNA (mRlncRNA) and lung adenocarcinoma (LUAD) remains unclear. This study aims to determine a feature based on mRlncRNA for prognostic evaluation of LUAD patients. By integrating the gene expression data of LUAD and normal samples from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database, the m6A gene and mRlncRNA with imbalanced expression were screened out. Then we used the least absolute shrinkage and selection operator (LASSO) to obtain the 13-lncRNA prognostic signature in the TCGA training cohort. Patients were divided into two risk groups based on the risk score of lncRNAs characteristics, and their overall survival (OS) was significantly different. The predictive power of this signature was verified in TCGA testing cohort and entire TCGA cohort. These landmark lncRNAs were involved in several biologiocal processes and pathways related to cell cycle, DNA replication, P53 signaling pathway and mismatch repair. Besides, the high-risk group was low-response to cisplatin, while high-response to mitomycin, docetaxel and immunotherapy. In conclusion, we identified a 13-mRlncRNA model associated with prognosis and treatment sensitivity in LUAD, which may provide clues about the influence of m6A on lncRNA in LUAD and promote the further improvement of LUAD individualized treatment strategies.
The Efficacy of Transarterial Chemoembolization in Downstaging Unresectable Hepatocellular Carcinoma to Curative Therapy: A Predicted Regression Model
Authors: LIN Hao Min , PENG Fang Yi , HUANG Bin , FANG Cheng , GAN Yu , YANG Xiao Li , LI Bo , Su Song 
Published: August 2021

Abstract
Background: Patients with hepatocellular carcinoma (HCC) outside the Milan criteria (MC) may be candidates for curative therapy after successful downstaging. However, there have been no studies that have examined the factors affecting the efficacy of transarterial chemoembolization (TACE) on downstaging. We aimed to identify the predictors of successful downstaging of unresectable HCC in patients by TACE outside the MC.Methods: We performed a retrospective study on patients with unresectable HCC outside the MC who received downstaging with TACE. Clinical and laboratory variables were recorded. We identified 101 patients with unresectable HCC who underwent initial TACE, and they formed the derivation set of this study. Thirty patients who received TACE treatment with the same selection criteria served as an external validation set. We performed multivariate logistic regression analyses to identify the variables associated with successful downstaging. Then, we created a predictive model and determined its accuracy in predicting the efficiency of TACE.Results: Of the 101 patients in the study, 26 patients (25.7%) were successfully downstaged. Multivariate analysis was performed on the number of tumors (P=0.018), portal vein tumor thrombi (PVTT) (＜0.001), the size of tumors (P=0.021), hepatitis B surface antigen (HBsAg) (P=0.014), and a-fetoprotein (AFP, P=0.027), which were considered as significant predictors of successful downstaging of HCC outside the MC. Then, we constructed the predictive model. The area under the ROC curve (AUROC) for the predictive equation was 0.908 (95% confidence interval, 0.832-0.957).Conclusions: We found in our study that the number and size of tumors, PVTT, HBsAg, and AFP are good predictors of successful downstaging of unresectable HCC in patients by TACE outside the MC.