bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood‐flow‐restricted exercise: Strategies for enhancing muscle adaptation and performance in the endurance‐trained athlete
Authors: Ferguson Richard A. , Mitchell Emma A. , Taylor Conor W. , Bishop David J. , Christiansen Danny 
Published: January 2021

New Findings

What is the topic of this review?
Blood‐flow‐restricted (BFR) exercise represents a potential approach to augment the adaptive response to training and improve performance in endurance‐trained individuals.

What advances does it highlight?
When combined with low‐load resistance exercise, low‐ and moderate‐intensity endurance exercise and sprint interval exercise, BFR can provide an augmented acute stimulus for angiogenesis and mitochondrial biogenesis. These augmented acute responses can translate into enhanced capillary supply and mitochondrial function, and subsequent endurance‐type performance, although this might depend on the nature of the exercise stimulus. There is a requirement to clarify whether BFR training interventions can be used by high‐performance endurance athletes within their structured training programme.

AbstractA key objective of the training programme for an endurance athlete is to optimize the underlying physiological determinants of performance. Training‐induced adaptations are governed by physiological and metabolic stressors, which initiate transcriptional and translational signalling cascades to increase the abundance and/or function of proteins to improve physiological function. One important consideration is that training adaptations are reduced as training status increases, which is reflected at the molecular level as a blunting of the acute signalling response to exercise. This review examines blood‐flow‐restricted (BFR) exercise as a strategy for augmenting exercise‐induced stressors and subsequent molecular signalling responses to enhance the physiological characteristics of the endurance athlete. Focus is placed on the processes of capillary growth and mitochondrial biogenesis. Recent evidence supports that BFR exercise presents an intensified training stimulus beyond that of performing the same exercise alone. We suggest that this has the potential to induce enhanced physiological adaptations, including increases in capillary supply and mitochondrial function, which can contribute to an improvement in performance of endurance exercise. There is, however, a lack of consensus regarding the potency of BFR training, which is invariably attributable to the different modes, intensities and durations of exercise and BFR methods. Further studies are needed to confirm its potential in the endurance‐trained athlete.
A Deep Lifelong Learning Method for Digital Twin-Driven Defect Recognition With Novel Classes
Authors: Yiping Gao , Xinyu Li , Gao Liang 
Published: January 2021

Abstract
Recently, digital twins (DTs) have become a research hotspot in smart manufacturing, and using DTs to assist defect recognition has also become a development trend. Real-time data collection is one of the advantages of DTs, and it can help the realization of real-time defect recognition. However, DT-driven defect recognition cannot be realized unless some bottlenecks of the recognition models, such as the time efficiency, have been solved. To improve the time efficiency, novel defect class recognition is an essential problem. Most of the existing methods can only recognize the known defect classes, which are available during training. For new incoming classes, known as novel classes, these models must be rebuilt, which is time-consuming and costly. This greatly impedes the realization of DT-driven defect recognition. To overcome this problem, this paper proposes a deep lifelong learning method for novel class recognition. The proposed method uses a two-level deep learning architecture to detect and recognize novel classes, and uses a lifelong learning strategy, weight imprinting, to upgrade the model. With these improvements, the proposed method can handle novel classes timely. The experimental results indicate that the proposed method achieves good results for the novel classes, and it has almost no delay for production. Compared with the rebuilt methods, the time cost is reduced by at least 200 times. This result suggests that the proposed method has good potential in the realization of DT-driven defect recognition.
Predicting Sequential Design Decisions Using the Function-Behavior-Structure Design Process Model and Recurrent Neural Networks
Authors: Rahman Molla Hafizur , Xie Charles , Sha Zhenghui 
Published: January 2021

Abstract
In engineering systems design, designers iteratively go back and forth between different design stages to explore the design space and search for the best design solution that satisfies all design constraints. For complex design problems, human has shown surprising capability in effectively reducing the dimensionality of design space and quickly converging it to a reasonable range for algorithms to step in and continue the search process. Therefore, modeling how human designers make decisions in such a sequential design process can help discover beneficial design patterns, strategies, and heuristics, which are essential to the development of new algorithms embedded with human intelligence to augment the computational design. In this paper, we develop a deep learning-based approach to model and predict designers’ sequential decisions in the systems design context. The core of this approach is an integration of the function-behavior-structure (FBS) model for design process characterization and the long short-term memory unit (LSTM) model for deep leaning. This approach is demonstrated in two case studies on solar energy system design, and its prediction accuracy is evaluated benchmarking on several commonly used models for sequential design decisions, such as the Markov Chain model, the Hidden Markov Chain model, and the random sequence generation model. The results indicate that the proposed approach outperforms the other traditional models. This implies that during a system design task, designers are very likely to rely on both short-term and long-term memory of past design decisions in guiding their future decision-making in the design process. Our approach can support human–computer interactions in design and is general to be applied in other design contexts as long as the sequential data of design actions are available.
Virtual Fixture Generation for Task Planning With Complex Geometries
Authors: Sharp Andrew , Pryor Mitch 
Published: January 2021

Abstract
Many robotic processes require the system to maintain a tool’s orientation and distance from a surface. To do so, researchers often use virtual fixtures (VFs) to either guide the robot along a path or forbid it from leaving the workspace. Previous efforts relied on volumetric primitives (planes, cylinders, etc.) or raw sensor data to define VFs. However, those approaches only work for a small subset of real-world objects. Extending this approach is complicated not only by VF generation but also by generalizing user traversal of the VF to command a robot trajectory remotely. In this study, we present the concept of task VFs, which convert layers of point cloud-based Guidance VF into a bidirectional graph structure and pair it with a Forbidden Region VF. These VFs are hardware-agnostic and can be generated from virtually any source data, including from parametric objects (superellipsoids, supertoroids, etc.), meshes (including from computer-aided design (CAD)), and real-time sensor data for open-world scenarios. We address surface convexity and concavity since these and distance to the task surface determine the size and resolution of VF layers. This article then presents the manipulator-to-task transform tool for task VF visualization and to limit human–robot interaction ambiguities. Testing confirmed generation success and users performed spatially discrete experiments to evaluate task VF usability complex geometries, which showed their interpretability. The manipulator-to-task transform tool applies many robotic applications, including collision avoidance, process design, training, task definition, etc. for virtually any geometry.
Surgical curriculum concordance: requiem for the educational dream
Authors: Luton Oliver , James Osian Penri , Mellor Katie , Powell Arfon , Hopkins Luke , Robinson David Bryan Thomas , Egan Richard , Lewis Wyn 
Published: January 2021

AbstractThis study aimed to analyse the degree of relative variation in speciality-specific competencies required for Certification of Completion of Training (CCT) set by the UK Joint Committee for Surgical Training (JCST) 2021 curriculum. Regulatory body guidance related to operative and non-operative surgical skill competencies required for CCT were analysed and compared. Wide inter-speciality variation was demonstrated in the minimum number of logbook cases (median 815; range 54 to 2100), indexed operations (8; 5 to 24) and procedure-based assessments (35; 6 to 110). Academic competencies related to peer-reviewed publications, communications to learned societies and audits were aligned at zero, zero and three across specialities, respectively. Mandatory courses have been standardised with Advanced Trauma Life Support being the sole pre-requisite CCT for all. JCST certification guidelines have broadly standardised competency domains, yet large discrepancies persist regarding operative indicative numbers and assessments. This article serves as a definitive CCT guide regarding prevailing changes.
Feasibility and acceptability of frequent vaginal self-sampling at home by Rwandan women at high risk of urogenital tract infections
Authors: Verwijs Marijn C , Agaba Stephen , Umulisa Marie-Michele , van de Wijgert Janneke H H M 
Published: January 2021

ObjectivesTo establish temporal links between vaginal microbiota (VMB) data and incident clinical events, frequent longitudinal vaginal sampling is required. Self-collection of swabs at the participant’s home may be useful to avoid overburdening research clinics and participants. One-off vaginal self-sampling for STI or cervical cancer screening programmes has been shown to be feasible and acceptable to women in multiple studies, including in sub-Saharan Africa, but the feasibility and acceptability of frequent longitudinal vaginal sampling in the context of VMB sequencing studies is unknown.MethodsTwelve participants of a randomised clinical trial in Kigali, Rwanda, self-collected vaginal swabs three times a week for a month. We studied feasibility by comparing DNA concentrations, proportions of samples with >1000 16S rRNA amplicon sequencing reads and VMB composition outcomes of self-collected swabs with clinician-collected swabs. We evaluated the acceptability of self-collection using structured face-to-face interviews and a focus group discussion.ResultsThe participants collected vaginal swabs at 131 different time points. One woman stopped self-sampling after one try due to a social harm. All self-sampled swabs generated >1000 rRNA amplicon sequencing reads, and the DNA concentration of self-sampled swabs and clinician-sampled swabs did not differ significantly (Kruskal-Wallis p=0.484). Self-sampled and clinician-sampled swabs generated similar VMB composition data. Participants reported feeling very comfortable during self-sampling (11/12; 91.7%) and that self-sampling had become easier over time (12/12; 100%). They mentioned reduced travel time and travel costs as advantages of self-sampling at home.ConclusionsFrequent longitudinal vaginal sampling at home is feasible and acceptable to participants, even in the context of a low-resource setting, as long as adequate counselling is provided.Trial registration numberNCT02459665.
Differential responses to child communicative behavior of parents of toddlers with ASD
Authors: De Froy Adrienne M , Sims Megan E , Sloan Benjamin M , Gajardo Sebastian A , Rollins Pamela Rosenthal 
Published: January 2021

Background and aims The quality of parent verbal input—diverse vocabulary that is well-matched to the child’s developmental level within interactions that are responsive to their interests—has been found to positively impact child language skills. For typically developing (TD) children, there is evidence that more advanced linguistic and social development differentially elicits higher quality parent input, suggesting a bidirectional relationship between parent and child. The purpose of this study was to evaluate if toddlers with ASD also differentially elicit parental verbal input by (1) analyzing the quality of parent input to the communicative behavior of their toddlers with ASD, (2) examining if parents respond differentially to more advanced toddler communicative behavior, as measured by the coordination of multiple communicative behaviors, and (3) exploring the relationship between parental responsiveness to child communicative behaviors and change in child communication and social skills. Methods Participants were 77 toddlers with ASD age 18-39 months and a parent who participated in a larger RCT. Ten-minute parent–toddler interactions were recorded prior to a 12-week intervention. Parent response to child communicative behaviors was coded following each child communicative behavior as no acknowledgment, responsive, directive, or nonverbal acknowledgment. Parent number of different words and difference between parent and child MLU in words were calculated separately for responsive and directive parent utterances. Child growth in language and social skills was measured using the Vineland II Communication and Socialization domain scores, respectively. Results (1) Parents were largely responsive to their toddler’s communication. When being responsive (as opposed to directive), parents used a greater number of different words within utterances that were well-matched to child language; (2) when toddlers coordinated communicative behaviors (versus producing an isolated communicative behavior), parents were more likely to respond and their replies were more likely to be responsive; and (3) parent responsiveness to child coordinated communication was significantly correlated with change in Vineland II Socialization but not Communication. A unique role of gaze coordinated child communication in eliciting responsive parental behaviors and improving growth in child social skills emerged. Conclusions Our results support a bidirectional process between responsive parent verbal input and the social development of toddlers with ASD, with less sophisticated child communicative behaviors eliciting lower quality parent input. Implications: Our findings highlight the critical role of early parent-mediated intervention for children with ASD generally, and to enhance eye gaze through parent responsivity more specifically.
A 1232 bp upstream sequence of glutamine synthetase 1b from Eichhornia crassipes is a root-preferential promoter sequence
Authors: Zhong Yanshan , Lu Xiaodan , Deng Zhiwei , Lu Ziqing , Fu Minghui 
Published: January 2021

Abstract
Background
Glutamine synthetase (GS) acts as a key enzyme in plant nitrogen (N) metabolism. It is important to understand the regulation of GS expression in plant. Promoters can initiate the transcription of its downstream gene. Eichhornia crassipes is a most prominent aquatic invasive plant, which has negative effects on environment and economic development. It also can be used in the bioremediation of pollutants present in water and the production of feeding and energy fuel. So identification and characterization of GS promoter in E. crassipes can help to elucidate its regulation mechanism of GS expression and further to control its N metabolism.

Results
A 1232 bp genomic fragment upstream of EcGS1b sequence from E. crassipes (EcGS1b-P) has been cloned, analyzed and functionally characterized. TSSP-TCM software and PlantCARE analysis showed a TATA-box core element, a CAAT-box, root specific expression element, light regulation elements including chs-CMA1a, Box I, and Sp1 and other cis-acting elements in the sequence. Three 5′-deletion fragments of EcGS1b upstream sequence with 400 bp, 600 bp and 900 bp length and the 1232 bp fragment were used to drive the expression of β-glucuronidase (GUS) in tobacco. The quantitative test revealed that GUS activity decreased with the decreasing of the promoter length, which indicated that there were no negative regulated elements in the EcGS1-P. The GUS expressions of EcGS1b-P in roots were significantly higher than those in leaves and stems, indicating EcGS1b-P to be a root-preferential promoter. Real-time Quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) analysis of EcGS1b gene also showed higher expression in the roots of E.crassipes than in stems and leaves.

Conclusions
EcGS1b-P is a root-preferential promoter sequence. It can specifically drive the transcription of its downstream gene in root. This study will help to elucidate the regulatory mechanisms of EcGS1b tissue-specific expression and further study its other regulatory mechanisms in order to utilize E.crassipes in remediation of eutrophic water and control its overgrowth from the point of nutrient metabolism.
Time- and dose-dependent correlations between patient-controlled epidural analgesia and intrapartum maternal fever
Authors: Zhao Bai-song , Li Bing , Wang Qing-ning , Jia Jun-xiang , Song Xing-rong 
Published: January 2021

Abstract
Background
To investigate the relationship between intrapartum maternal fever and the duration and dosage of patient-controlled epidural analgesia (PCEA).

Methods
This observational study included 159 pregnant women who voluntarily accepted PCEA. During labor, patients with body temperature ≥ 38 °C were classified into the Fever group, (n = 42), and those with body temperature < 38 °C were classified into the No-fever group (n = 117). The outcome measures included the duration of PCEA, number of PCEA, and total PCEA amount. Body temperature and parturient variables, including interpartum fever status and the duration of any fever were monitored.

Results
The total PCEA duration and total PCEA amount in the Fever group were significantly higher than the corresponding values in the No-fever group (both, p < 0.05). The duration of fever was weakly correlated with the duration of PCEA (R2 = 0.08) and the total PCEA amount (R2 = 0.05) (both, p < 0.05). The total and effective PCEA were higher in the Fever group than in the No-fever group (both, p < 0.05). The total PCEA duration and total PCEA amount were positively correlated with the incidence of fever (both, p < 0.05). The diagnostic cutoff value for fever was 383 min, with a sensitivity of 78.6% and specificity of 57.3%. The mean temperature-time curves showed that parturients who developed fever had a steeper rise in temperature.

Conclusions
This study showed that there were weak time- and dose-dependent correlations between PCEA and maternal fever during delivery. A total PCEA duration exceeding 6.3 h was associated with an increase in the duration of maternal intrapartum fever.
Relationship between chewing tobacco, smoking, consuming alcohol and cognitive impairment among older adults in India: a cross‐sectional study
Authors: Muhammad T. , Govindu Manideep , Srivastava Shobhit 
Published: January 2021

Abstract
Background
Physical aging increases the sensitivity to the effects of substance use, elevating the risk for cognitive impairment among older adults. Since studies on the association of substance use with cognitive ability in later years are scant in India, we aimed to explore the factors associated with cognitive impairment especially, alcohol consumption, smoking, and chewing tobacco later in life.

Methods
The present research used nationally representative data from Building a Knowledge Base on Population Aging in India (BKPAI) that was conducted in 2011, across seven states of India (N=9,453). Sample distribution along with percentage distribution was calculated for cognitive impairment over explanatory variables. For finding the association between cognitive impairment over explanatory variables, binary logistic regression models were estimated.

Results
About 16.5 percent of older adults in rural areas consumed smoked tobacco compared to 11.7 percent in urban areas. Nearly, 23.7 percent of rural older adults consumed smokeless tobacco in comparison to 16 percent in urban areas. Alcohol consumption was high among rural residents (7.9%) than urban counterparts (6.7%). The prevalence of cognitive impairment was 62.8% and 58% among older adults from rural and urban areas respectively. Older adults who smoked tobacco had a 24 percent significantly higher likelihood to have cognitive impairment with reference to older adults who did not smoke [OR: 1.24, CI: 1.02-1.49]. Moreover, older adults who consumed alcohol had a 30 percent significantly higher likelihood to have cognitive impairment [OR: 1.02, 1.65]. It was also found that older adults who had smoked along with consuming alcohol were at risk of worse cognitive outcomes than those who neither smoke nor drink alcohol [OR: 1.56, CI: 1.21-2.00] or consumed either of them unlike consuming smokeless tobacco only.

Conclusion
The encouragement of older people to stop smoking and smokeless tobacco use could be considered as part of a strategy to reduce the incidence of cognitive impairment. Further, appropriate measures should be taken for the detection of early stages of cognitive decline in older individuals and efforts should be made to improve the availability and quality of care for dementing older adults.
Low serum parathyroid hormone is a risk factor for peritonitis episodes in incident peritoneal dialysis patients: a retrospective study
Authors: Yang Yuqi , Da Jingjing , Jiang Yi , Yuan Jing , Zha Yan 
Published: January 2021

Abstract
Background
Serum parathyroid hormone (PTH) levels have been reported to be associated with infectious mortality in peritoneal dialysis (PD) patients. Peritonitis is the most common and fatal infectious complication, resulting in technique failure, hospital admission and mortality. Whether PTH is associated with peritonitis episodes remains unclear.

Methods
We examined the association of PTH levels and peritonitis incidence in a 7-year cohort of 270 incident PD patients who were maintained on dialysis between January 2012 and December 2018 using Cox proportional hazard regression analyses. Patients were categorized into three groups by serum PTH levels as follows: low-PTH group, PTH < 150 pg/mL; middle-PTH group, PTH 150-300 pg/mL; high-PTH group, PTH > 300 pg/mL.

Results
During a median follow-up of 29.5 (interquartile range 16–49) months, the incidence rate of peritonitis was 0.10 episodes per patient-year. Gram-positive organisms were the most common causative microorganisms (36.2%), and higher percentage of Gram-negative organisms was noted in patients with low PTH levels. Low PTH levels were associated with older age, higher eGFR, higher hemoglobin, calcium levels and lower phosphate, alkaline phosphatase levels. After multivariate adjustment, lower PTH levels were identified as an independent risk factor for peritonitis episodes [hazard ratio 1.643, 95% confidence interval 1.014–2.663, P = 0.044].

Conclusions
Low PTH levels are independently associated with peritonitis in incident PD patients.