bluuebunny/crossref_metadata_2025_split huggingface dataset:
"Can it be a generic?": a study on the buying behavior of Brazilian medicine consumers
Authors: Froda Isabela Alves , Carvalho Marcelo , Lopes Evandro Luiz , Pinochet Luis Hernan Contreras 
Published: January 2021

Objetivo: o objetivo deste estudo é identificar os fatores que influenciam o consumidor na compra de medicamentos e entender a percepção dos consumidores acerca da eficácia dos genéricos. Metodologia: o estudo é caracterizado por uma pesquisa quantitativa, na qual participaram 386 consumidores de medicamentos, cujos dados foram analisados por meio de estatísticas descritivas, análise de correlação bivariada e por meio de regressão linear múltipla. Originalidade: o estudo avançou em um gap acerca da identificação de fatores comportamentais que podem potencializar a aceitação de medicamentos genéricos no Brasil. Principais resultados: descobrimos que grande parte da amostra não reconhece que um medicamento genérico tem o mesmo efeito que um medicamento de referência. Contribuições teóricas: identificamos os fatores que explicam a eficácia percebida acerca dos medicamentos genéricos. Contribuições gerenciais: promover medidas educativas para a população e profissionais de saúde pode ser uma boa orientação, gerando benefícios ao possibilitar a transferência de recursos para investimentos em outras áreas da saúde.
A relationship between technostress, satisfaction at work, organizational commitment and demography: evidence from the Brazilian public sector
Authors: Marchiori Danilo Magno , Felix Ana Carolina Siqueria , Popadiuk Silvio , Mainardes Emerson Wagner , Rodrigues Ricardo Gouveia 
Published: January 2021

The literature is full of works that highlight the positive effects of the application of information technology on business processes, including gains in terms of transparency, efficiency and effectiveness. However, there is a growing number of studies showing that, in parallel with technological innovation, phenomena occur that cause distress and malaise to the workers, with studies on technostress being highlighted, that is, the difficulty of adapting to technological innovations in the work environment. However, few studies have been carried out to understand the negative effects of this technological transformation on public servants. Thus, the objective of this study is to identify the role of technostress on job satisfaction and organizational commitment in the context of the public sector. The technique of analysis of structural equations (CB-SEM) to analyze data collected with users of information technology from a Brazilian public organization. We have identified that the technostress negatively affects the satisfaction, which, in turn, positively impacts the commitment. In a complementary way, the relation between the demographic characteristics of the workers and the creators of technostress are presented in detail. As a result, several theoretical and practical implications are also discussed.
A associação da qualidade dos serviços prestados na intenção de reutilização da oficina de concessionárias automotivas autorizadas
Authors: De Oliveira Emerson Soares Souza , Teixeira Aridelmo 
Published: January 2021

Objetivo do estudo: Este estudo busca identificar quais são os fatores da qualidade dos serviços prestados pela assistência técnica das concessionárias automotivas autorizadas que antecedem a intenção de reutilização dos serviços da oficina.Metodologia/abordagem: Foi associado à intenção de reutilização aos construtos da escala da Qualidade na Prestação de Serviços (QPS). Também foram utilizadas três perguntas da escala de Emoção-Encantamento do Cliente, do construto propensão à recomendação de reutilização. Foi realizado um estudo de campo com uma amostra composta por 884 clientes de assistência técnica de concessionária automotiva autorizada, utilizando-se um questionário on-line. Utilizada a técnica de modelagem de equações estruturais (MEE) com o método PLS (partial least squares).Originalidade/Relevância: Neste estudo a justificativa teórica se encontra na novidade quando apresenta a ligação direta entre os construtos da qualidade percebida com a intenção de reutilização, algo ainda pouco explorado anteriormente.Principais resultados: Os resultados mostraram que aproximadamente setenta e cinco porcento da Intenção de Reutilização estão relacionados aos construtos Confiança, Relações Pessoais e Soluções de problemas. Os resultados também mostram que dois construtos: Aspectos Físicos e Políticas Internas não foram significativos na percepção do cliente.Contribuições teóricas/metodológicas: Estes achados permitem discussões no ambiente acadêmico, analisando a prestação dos serviços com a reutilização e suas implicações e na área empresarial buscando entender o comportamento dos clientes e suas intenções de reutilização dos serviços oferecidos pelas organizações.
PURWARUPA PENGENALAN JENIS BUAH INDONESIA BERBASIS AUGMENTED REALITY PADA PERANGKAT MOBILE ANDROID
Authors: R. Dewi Agushinta 
Published: January 2021

Teknologi saat ini bisa digunakan untuk pembelajaran dan pengetahuan mengenai berbagai jenis objek yang ada di dunia. Buah menjadi objek atau komoditi yang sangat penting karena meningkatkan stamina dan kekebalan daya tahan tubuh. Buah Indonesia sangat beragam. Banyak orang Indonesia sendiri tidak mengenal ragam jenis buah di Indonesia. Tulisan ini membahas mengenai pengenalan jenis buah yang akan memberikan informasi lengkap tentang buah Indonesia dengan menggunakan perangkat bergerak berbasis Android. Metode untuk pengembangan purwarupa ini menggunakan metode <em>Waterfall</em> umum. Metode ini terdiri dari tahap analisis, desain, pengembangan, implementasi dan evaluasi (ADDIE). Purwarupa ini menggunakan <em>cloud recognition</em> untuk menghubungkan gambar buah Indonesia yang diakuisisi oleh perangkat bergerak. Gambar buah ini akan ditemukenalikan ke server Vuforia yang menyimpan data gambar buah Indonesia dan deskripsinya. Kedua data ini ditampilkan dengan teknologi <em>Augmented Reality</em> melalui perangkat bergerak tersebut. Hasil penelitian purwarupa ini menunjukkan bahwa fungsionalitas dari aplikasi secara keseluruhan berjalan dengan baik. Perangkat ini berhasil diinstalasi dan dijalankan pada perangkat bergerak.
FAKTOR–FAKTOR YANG MEMPENGARUHI KONSUMSI SAYURAN RUMAH TANGGA PADA KAWASAN RUMAH PANGAN LESTARI DI KOTA SAMARINDA DAN BONTANG
Authors: Widyawati Afrilia Tri , Amin Muhammad 
Published: January 2021

<p align="center"><strong>ABSTRACT</strong></p><p align="center"><strong>FAKTOR – FAKFAKTOR – FAKTOR YANG MEMPENGARUHI KONSUMSI SAYURAN RUMAH TANGGA PADA KAWASAN RUMAH PANGAN LESTARI DI KOTA SAMARINDA DAN BONTANGTOR YANG MEMPENGARUHI KONSUMSI SAYURAN RUMAH TANGGA PADA KAWASAN RUMAH PANGAN LESTARI DI KOTA SAMARINDA DAN BONTANG</strong><strong> </strong></p><p>Backyard has a potential to feed the<strong> </strong>family as vegetables cropland or fruit crops. Sustainable Food Reserved Garden Program (SFRG) was designed to increase the potential of backyard to provide sustainable cheap food. This study aimed to analyze the factors affecting household’s vegetables consumption in the area of SFRG program. The research was conducted in Samarinda and Bontang City in 2018, involving 60 respondents who have implemented the program. Respondents were divided into three strata according yard size, which are stratum 1 (narrow), stratum 2 (medium) and stratum 3 (extensive). Data was collected through interviews using a structured questionnaire and <em>focus group discussions</em> with managers of the program. Afterwards, the data were analyzed descriptively. The result showed that the variations of plants types tend to be uniform among the three strata such as eggplant, peppers, tomatoes, cabbage, kale, leeks and spinach. In terms of the arrangement, narrow stratum was dominated by “vertikultur”, medium stratum by polybag and extensive stratum by seedbeds.</p><p> </p><p><strong>Key words</strong>:<strong> </strong><em>SFRG, vegetables consumption, backyard, vegetables production</em></p><p> </p><p align="center"><strong> </strong></p><p align="center"><strong>ABSTRAK</strong></p><p> </p><p>Optimalisasi pemanfaatan lahan pekarangan penting untuk memenuhi kebutuhan pangan dan sayuran bagi keluarga. Melalui program Kawasan Rumah Pangan Lestari (KRPL) diharapkan dapat menyediakan pangan murah yang berkelanjutan. Penelitian bertujuan menganalisis faktor-faktor yang mempengaruhi konsumsi sayuran rumah tangga di Kawasan Rumah Pangan Lestari. Penelitian dilaksanakan di Kota Samarinda dan Bontang tahun 2018 melibatkan 60 responden pelaksana program KRPL. Responden dibedakan ke dalam tiga strata berdasarkan luas pekarangan, yaitu strata 1 (sempit), strata 2 (sedang) dan strata 3 (luas). Pengumpulan data dilakukan dengan wawancara menggunakan kuesioner terstruktur dan <em>Focus Group Discussion</em> melibatkan pengelola program KRPL. Data dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa variasi jenis tanaman cenderung seragam antar strata, dengan tanaman dominan terong, cabai, tomat, sawi, kangkung, bawang daun dan bayam. Penataan tanaman pada strata satu dominan vertikultur, strata dua menggunakan polibag dan strata tiga dengan bedengan.</p><p> </p><p><strong>Kata kunci</strong>:<strong> </strong>KRPL, konsumsi sayuran, pekarangan, produksi sayuran.</p>
Influence of the Different Carbon and Nitrogen Sources on the Production of Biodiesel by Oleaginous Fungi Aspergillus terreus, Aspergillus fumigatus
Authors: Shafiq Shatha Ali , Abdulkareem Afrah Fahad , Shafi Farha A. Ali 
Published: January 2021

In the present study, the growth and total lipid contents of two oleaginous fungal isolates Aspergillus terreus, Aspergillus fumigatus were compared in different nitrogen and organic carbon sources. Artificially the fungi were cultured on media consisting of various mono- or di- or polysaccharides and peptone or yeast extract as elementary sources for carbon and nitrogen, respectively. Media containing sucrose /yeast extract or glucose/ yeast extract were the most effective for lipid production from fungal, during two weeks incubation period, the highest biomass of dry weight was (19.6 , 18.8) g / L , (25.8 , 30.5) g /L and lipid yield (1, 0.97 )g/L, (0.65, 0.65) g/ L for two isolates Aspergillus terreus and Aspergillus fumigatus respectively then followed maltose/ yeast extract then starch / yeast extract .Analysis of fatty acid produced by two fungal isolates using Gas Chromatography showed the existence of a wide range of fatty acids, these fatty acids were together saturated and unsaturated. The results revealed that the unevenness in the fatty acids composition mainly depends on the type of carbon and nitrogen sources. The existence of saturated and mono saturated fatty acids in A.fumigatus, A. terreus prove that they are good candidate for biodiesel production.
The analysis of fatty acid from the fungal growth showed the existence of a wide range of fatty acids Palmitic ,Oleic acids , stearic acid and linoleic acid together saturated and unsaturated. The results revealed that the unevenness in the fatty acid composition mainly depends on the type of carbon and nitrogen sources. The presence of saturated and mono saturated fatty acid in A.fumigatus , A. terreus prove that it is a good candidate for biodiesel production.
Synthesis, Characterization and Gas Sensor Application of New Composite Based on MWCNTs:CoPc:Metal Oxide
Authors: Kareem Mohanad Mousa , Kadem Burak Yahya , Mohammad Emman J. , Atiyah Abbas Jassim 
Published: January 2021

The synthesis of new substituted cobalt Phthalocyanine (CoPc) was carried out using starting materials Naphthalene-1,4,5, tetracarbonic acid dianhydride (NDI) employing dry process method. Metal oxides (MO) alloy of (60%Ni3O4 40%-Co3O4 ) have been functionalized with multiwall carbon nanotubes (F-MWCNTs) to produce (F-MWCNTs/MO) nanocomposite (E2) and mixed with CoPc to yield (F-MWCNT/CoPc/MO) (E3). These composites were investigated using different analytical and spectrophotometric methods such as 1H-NMR (0-18 ppm), FTIR spectroscopy in the range of (400-4000cm-1), powder X-rays diffraction (PXRD, 2θ o = 10-80), Raman spectroscopy (0-4000 cm-1), and UV-Visible spectrophotometry (0-800 nm). Then the activity of these materials was investigated as a gas sensing of (Ammonia, Methanol and Acetone). For each case, 0.2 mg/.mL of the prepared Copc, Copc/MWCNT, Copc/MWCNTs–MO was dispersed in 1m of ammonia, methanol and acetone at 298K. The surface morphology of the prepared materials was heterogeneous.
A Retrospective Study Correlating Ultrasound Based Thyroid Imaging Reporting and Data System (TIRADS) with Bethesda System for Thyroid Cytopathology in Thyroid Nodule Risk Stratification
Authors: Chaturvedi Rajeev , Kumar Ashok , Balasubramanian Balaji , Sreehari Sreekala 
Published: January 2021

Objective:
To evaluate the efficacy of the ultrasound-based Thyroid Imaging Reporting and Data System (TIRADS) in estimating the risk of malignancy in
thyroid nodules by correlating it with the Bethesda system of thyroid cytopathology.

Methods:
A retrospective single-center study was conducted in a specialty hospital in UAE from November 2017 to November 2019 on 259 thyroid nodules
that underwent ultrasound and fine-needle aspiration cytology (FNAC). Thyroid nodules were evaluated using American College of Radiology
(ACR) TIRADS and categorized as benign (TR1), not suspicious (TR2), mildly suspicious (TR3), moderately suspicious (TR4), or highly
suspicious (TR5) for malignancy. The risk of malignancy associated with each TIRADS category was evaluated by comparing it with the Bethesda
classification system of cytopathology.

Results:
Ultrasound and FNAC data of 259 nodules were reviewed. Out of these, 33 (12.7%) nodules were excluded because FNAC revealed atypia of
undetermined significance or follicular lesion of undetermined significance. The estimated risk of malignancy in TR 3 was 13.6%, TR4 was 27%,
and TR5 was 63.6%. There was a statistically significant correlation between TIRADS and Bethesda system, which was determined using the Chisquare
test (p < 0.001). The receiver operating curve (ROC) analysis revealed specificity of 81.3% [95% CI, 74.9 - 86.6%], NPV of 91% [95% CI,
87.1 – 93.8%] and accuracy of 77.9% [95% CI, 71.9 – 83.1%], when differentiating benign from malignant nodules.

Conclusion:
The ultrasound-based ACR-TIRADS scoring correlates well with the Bethesda cytopathology in thyroid nodule risk stratification. Thus, it can be
used as a simple and effective tool to decide further management and avoid unnecessary FNAC and surgeries in thyroid nodules.
In Silico Prediction and Designing of Potential siRNAs to be used as Antivirals Against SARS-CoV-2
Authors: Sohrab Sayed S. , El-Kafrawy Sherif A. , Abbas Aymn T. , Bajrai Leena H. , Azhar Esam I. 
Published: January 2021

Background:
The unusual pneumonia outbreak that originated in the city of Wuhan, China in December
2019 was found to be caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or
COVID-19.

Methods:
In this work, we have performed an in silico design and prediction of potential siRNAs based on genetic
diversity and recombination patterns, targeting various genes of SARS-CoV-2 for antiviral therapeutics.
We performed extensive sequence analysis to analyze the genetic diversity and phylogenetic relationships, and
to identify the possible source of virus reservoirs and recombination patterns, and the evolution of the virus as
well as we designed the siRNAs which can be used as antivirals against SARS-CoV-2.

Results:
The sequence analysis and phylogenetic relationships indicated high sequence identity and closed clusters
with many types of coronavirus. In our analysis, the full-genome of SARS-CoV-2 showed the highest sequence
(nucleotide) identity with SARS-bat-ZC45 (87.7%). The overall sequence identity ranged from 74.3%
to 87.7% with selected SARS viruses. The recombination analysis indicated the bat SARS virus is a potential
recombinant and serves as a major and minor parent. We have predicted 442 siRNAs and finally selected only
19 functional, and potential siRNAs.

Conclusions:
The siRNAs were predicted and selected based on their greater potency and specificity. The predicted
siRNAs need to be validated experimentally for their effective binding and antiviral activity.
Retinal Protein O-GlcNAcylation and the Ocular Renin-angiotensin System: Signaling Cross-roads in Diabetic Retinopathy
Authors: Dennis Michael D. , Dierschke Sadie K. 
Published: January 2021

Abstract::
It is well established that diabetes and its associated hyperglycemia negatively impacts retinal function, yet we know little about the role played by augmented flux through the hexosamine biosynthetic pathway (HBP). This offshoot of the glycolytic pathway produces UDP-N-acetyl-glucosamine which serves as the substrate for post-translational Olinked modification of proteins in a process referred to as O-GlcNAcylation. HBP flux and subsequent protein OGlcNAcylation serve as a nutrient sensor, enabling cells to integrate metabolic information to appropriately modulate fundamental cellular processes including gene expression. Here we summarize the impact of diabetes on retinal physiology, highlighting recent studies that explore the role of O-GlcNAcylation-induced variation in mRNA translation in retinal dysfunction and the pathogenesis of diabetic retinopathy (DR). Augmented O-GlcNAcylation results in widespread variation in the selection of mRNAs for translation, in part, due to O-GlcNAcylation of the translational repressor 4E-BP1. Recent studies demonstrate that 4E-BP1 plays a critical role in regulating O-GlcNAcylation-induced changes in translation of the mRNAs encoding vascular endothelial growth factor (VEGF), a number of important mitochondrial proteins, and CD40, a key costimulatory molecule involved in diabetes-induced retinal inflammation. Remarkably, 4E-BP1/2 ablation delays the onset of diabetes-induced visual dysfunction in mice. Thus, pharmacological interventions to prevent the impact of O-GlcNAcylation on 4E-BP1 may represent promising therapeutics to address the development and progression of DR. In this regard, we discuss the potential interplay between retinal O-GlcNAcylation and the ocular renin-angiotensin system as a potential therapeutic target of future interventions.
Therapeutic Potential of Herbal Molecules against Breast Cancer
Authors: Gupta Ramji , Mishra Prem Shankar , Kala Nidhi , Pai Aravinda , Malviya Rishabha 
Published: January 2021

Background:
Since last decades, breast cancer has emerged as one of the most aggressive
forms of cancer which causes the highest mortality rates. The synthetic drugs that are available
for the treatment of breast cancer either have high toxicity or becoming resistant. Given this, researchers
are constantly in search of natural drugs that can control aggressive breast cancer and at
the same time possess less toxicity.

Aim:
The manuscript aims to summarize potential herbal molecules having significant activity
against breast cancer.

Methods:
Extensive literature survey was carried out to compile data obtained from primary and secondary
information sources. Google Scholar, Science Direct, Bentham Science, Springer,
PubMed, etc. were used as the source of data.

Results:
In the present review, an attempt has been made to summarize herbal molecules that have
shown promising results against breast cancer either in preliminary studies or in clinical studies.
Herbal molecules gain good attention among the scientific community for their therapeutic properties
against breast cancer.

Conclusion:
After the literature survey, it was also concluded that herbal molecules have significant
potential to control the growth of breast cancer.
Pesticides-induced Cardiovascular Dysfunctions: Prevalence and Associated Mechanisms
Authors: Adeyemi Joseph A. , Ukwenya Victor O. , Arowolo Olatunbosun K. , Olise Christian C. 
Published: January 2021

:
Increased applications of pesticides, mainly in agriculture and public health, have resulted
in increased chances of human exposure to pesticides. Chronic exposure to pesticides has
been implicated in several human diseases, including cardiovascular diseases. Cardiovascular diseases
are broadly used for various heart pathological conditions, including a defect in blood vessels,
and they include myocardial infarction, atherosclerosis, stroke, cardiomyopathy, coronary heart
disease, etc. In this review, the association between human exposure to pesticides and the development
of cardiovascular diseases was discussed using epidemiological and laboratory data. The toxicokinetics
of pesticides in humans was reviewed, as well as the risk factors for cardiovascular diseases.
The important role of oxidative stress principally the induction of reactive oxygen species as
the signaling molecules for various signaling pathways involved in pesticides-induced cardiovascular
disease, was discussed.
Determination of Salicylic Acid Using a Highly Sensitive and New Electroanalytical Sensor
Authors: Montazarolmahdi Maliheh , Masrournia Mahboubeh , Nezhadali Azizollah 
Published: January 2021

Background:A drug sensor (salicylic acid, in this case) was designed and made up of this research. The senor was made by modification of paste electrode (MPE) with CuO-SWCNTs and 1-hexyl-3-methylimidazolium chloride (HMICl). The MPE/CuO-SWCNTs/HMICl showed catalytic activity for the oxidation signal of salicylic acid in phosphate buffer solution.Methods:Electrochemical methods were used as a powerful strategy for the determination of salicylic acid in pharmaceutical samples. Aiming at this goal, carbon paste electrode was amplified with conductive materials and used as a working electrode.Results:The MPE/CuO-SWCNTs/HMICl was used for the determination of salicylic acid in the concentration range of 1.0 nM – 230 µM using differential pulse voltammetric (DPV) method. At pH=7.0, as optimum condition, the MPE/CuOSWCNTs/HMICl displayed a high-quality ability for the determination of salicylic acid in urine, pharmaceutical serum, and water samples.Conclusion:The MPE/CuO-SWCNTs/HMICl was successfully used as a new and high performance working electrode for the determination of salicylic acid at a nanomolar level and in real samples.