bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation of the health-promoting practices of Australian universities
Authors: McDonald Hayden , Gould Ryan , Delaney Deborah , Vecchio Nerina 
Published: January 2021

Summary
Workplace health promotion programmes (WHPPs) are more likely to succeed where design and implementation account for the influence of health’s complex, systemic nature. Thus, a greater understanding of how frameworks developed to progress WHPPs are operationalized across different countries and industries is needed. This study investigates health concerns targeted in an underexplored setting—Australian universities, describing how diverse programmes are implemented to target different health issues and health risk factors. Content analysis is used to outline how Australian universities implement WHPPs to target diverse health concerns. Content from 497 website documents is collected and analysed using NVivo software. A framework for examining diverse WHPPs currently used in practice is developed. Based on this framework, it was evident that Australian universities emphasized initiatives targeting health issues focusing on ‘mental health’ and ‘diabetes’. Regarding health risk factors, ‘alcohol and other addictions’, ‘discrimination and harassment’, and ‘physical activity’ were emphasized. Links between different health concerns targeted and corresponding WHPPs implemented, provide workplaces with a benchmark for designing and implementing programmes. University WHPPs targeted a diverse range of health concerns when enough legal and political motivations to do so existed. These findings about the motivations for improving employee health indicate a potential gap between health promotion benefits reported in literature and the appreciation for these benefits in practice.
Development of a multimedia intervention to improve pneumoconiosis prevention in construction workers using RE-AIM framework
Authors: Chen Jieling , Wong Cho Lee , Law Bernard Man Hin , So Winnie Kwok Wei , Leung Doris Yin Ping , Chan Carmen Wing Han 
Published: January 2021

Summary
Pneumoconiosis is a common occupational lung disease among construction workers. Educational interventions targeting specific ethnic groups of construction workers are of benefit for pneumoconiosis prevention. The aim of this study was to develop a multimedia educational intervention for pneumoconiosis prevention for South Asian construction workers, and to evaluate its feasibility, acceptability and effectiveness in increasing knowledge of pneumoconiosis, modifying beliefs about pneumoconiosis, and enhancing intention to implement measures for its prevention among the workers. This evaluation was performed using the Reach-Effectiveness-Adoption-Implementation-Maintenance framework. A one-group design was adopted and intervention mapping was used to guide the process of intervention development, while the Health Belief Model guided the development of intervention content. The intervention was delivered at construction sites, ethnic minority associations and South Asian community centres. Data were collected via surveys completed at pre-intervention, post-intervention and 3 months after the intervention. A total of 1002 South Asian construction workers participated in the intervention. The participants reported a moderate-to-large increase in knowledge, perceived susceptibility, perceived severity, perceived benefits, cues to action and self-efficacy (Cohen’s d: 0.37–0.89), a small reduction in perceived barriers (Cohen’s d = 0.12) and a moderate improvement in attitudes and intention to practice (Cohen’s d: 0.45, 0.51) at post-intervention. A follow-up survey of 121 participants found that the implementation of preventive measures appeared to increase. Overall, the findings demonstrate that the implementation of a culturally adapted multimedia educational intervention could be an effective approach to improving knowledge, self-efficacy and intention regarding pneumoconiosis prevention among South Asian construction workers.
Internet use and health in higher education students: a scoping review
Authors: Rouvinen Hanna , Jokiniemi Krista , Sormunen Marjorita , Turunen Hannele 
Published: January 2021

SummaryThe amount of time spent online has increased over the last decade among higher education students. Students engage in online activities related to studies, work, leisure, entertainment and electronic services (e-services) use. The Internet is also used for health-related matters. The increase in the use of the Internet has influenced students’ health, especially mental and physical health and well-being. This scoping review scrutinizes the literature between 2015 and 2020 (N = 55) on the association between Internet use and health in higher education students. A methodological framework, outlined by Arksey and O'Malley, was applied to conduct this review. Systematic searches were carried out in the CINAHL, PubMed and Scopus databases and in the available grey literature. For the data, a thematic analysis by Braun and Clarke was utilized. Two major themes of ‘Health-promoting Internet use’ and ‘Health-threatening Internet use’ emerged and are described in this review.
Thyroid autoimmunity is associated with higher risk of premature ovarian insufficiency—a nationwide Health Insurance Research Database study
Authors: Hsieh Yi-Ting , Ho Jason Y P 
Published: January 2021

Abstract

STUDY QUESTION
Is thyroid autoimmunity associated with a higher risk of low ovarian reserve and POI?

SUMMARY ANSWER
Thyroid autoimmunity significantly increases the risk of POI in women.

WHAT IS KNOWN ALREADY
POI is closely related with autoimmune disease, and according to some studies, thyroid autoimmunity (TAI) may account for diminished ovarian reserve. However, no large-scale cohort study has demonstrated the association between TAI and POI.

STUDY DESIGN, SIZE, DURATION
A longitudinal population-based retrospective cohort study on the National Health Insurance Research Database (NHIRD) was designed. Since 1 March 1995, the National Health Insurance (NHI) programme in Taiwan has included 99.9% of the 23 million population of Taiwan. Patients between 1 January 2000 and 31 December 2012 were eligible for recruitment, and 21 325 subjects were analysed in our study.

PARTICIPANTS/MATERIALS, SETTING, METHODS
Two cohorts, Hashimoto’s and Grave’s disease, were composed of patients with autoimmune thyroid disease between 20 and 40 years of age. The comparison cohorts consisted of patients in the NHIRD without autoimmune thyroid disease matched by age at a ratio of 1:4 in subject numbers.

MAIN RESULTS AND THE ROLE OF CHANCE
The Hashimoto's disease (HD) cohort, Grave's disease (GD) cohort and two comparison cohorts were followed up until a diagnosis of amenorrhoea, menopausal syndrome, other ovarian failure or infertility due to ovarian failure had been made. Compared statistically with the non-HD cohort, patients with HD exhibited an 89% higher risk of amenorrhoea (95% CI =1.36–2.61). The HD patients exhibited a 2.40-fold higher risk of infertility due to ovarian failure than the non-HD subjects (hazard ratio (HR)=2.40, 95% confidence interval (CI)=1.02–5.68). In comparison with the non-GD cohort, patients with GD exhibited a 68% higher risk of amenorrhoea (95% CI = 1.43–1.98) after adjustment. According to the Kaplan–Meier analysis, the cumulative incidence of amenorrhoea and menopausal syndrome was significantly higher in the TAI groups than in the control groups.

LIMITATIONS, REASONS FOR CAUTION
This is a retrospective study using ICD-9 disease code analysis to determine the statistical association between two diseases.

WIDER IMPLICATIONS OF THE FINDINGS
Given that autoimmune thyroid disease is highly associated with early diminished ovarian reserve or even premature ovarian failure or POI, the options for infertility treatment may be re-directed to more efficient methods in infertile patients diagnosed with the disease. If the ovarian reserve is normal at the time of diagnosis of thyroid autoimmune disease, close follow-up of ovarian reserve may be highly recommended.

STUDY FUNDING/COMPETING INTEREST(S)
This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center, Grant Number: MOHW109-TDU-B-212-114004. The authors have no conflicts of interest to declare.

TRIAL REGISTRATION NUMBER
N/A.
Forging a New Path in English-French Lexicography: Guy Miège in Relation to Robert Sherwood
Authors: Francoeur Aline 
Published: January 2021

AbstractFrom 1632 to the late 1670s, the English-French lexicographic scene was monopolized by Robert Sherwood’s Dictionaire Anglois & François, which was annexed to Randle Cotgrave’s second edition of the Dictionarie of the French and English Tongues and reissued in all subsequent editions (1650, 1660, and 1673). Sherwood’s work would have been the source of choice for any lexicographer wanting to compile a new English-French dictionary. However, for Guy Miège, the author of A New Dictionary French and English, with another English and French published in 1677, Sherwood’s dictionary seems to have been a minor influence at best. What the relation between them sets forth is the significantly new range and originality of Miège’s work in comparison, as demonstrated in this study.
Folding of Hitchin Systems and Crepant Resolutions
Authors: Beck Florian , Donagi Ron , Wendland Katrin 
Published: January 2021

Abstract
Folding of ADE-Dynkin diagrams according to graph automorphisms yields irreducible Dynkin diagrams of $\textrm{ABCDEFG}$-types. This folding procedure allows to trace back the properties of the corresponding simple Lie algebras or groups to those of $\textrm{ADE}$-type. In this article, we implement the techniques of folding by graph automorphisms for Hitchin integrable systems. We show that the fixed point loci of these automorphisms are isomorphic as algebraic integrable systems to the Hitchin systems of the folded groups away from singular fibers. The latter Hitchin systems are isomorphic to the intermediate Jacobian fibrations of Calabi–Yau orbifold stacks constructed by the 1st author. We construct simultaneous crepant resolutions of the associated singular quasi-projective Calabi–Yau three-folds and compare the resulting intermediate Jacobian fibrations to the corresponding Hitchin systems.
Stochastic Ricci Flow on Compact Surfaces
Authors: Dubédat Julien , Shen Hao 
Published: January 2021

Abstract
In this paper we introduce the stochastic Ricci flow (SRF) in two spatial dimensions. The flow is symmetric with respect to a measure induced by Liouville conformal field theory. Using the theory of Dirichlet forms, we construct a weak solution to the associated equation of the area measure on a flat torus, in the full “$L^1$ regime” $\sigma &lt; \sigma _{L^1}=2 \sqrt \pi $ where $\sigma $ is the noise strength. We also describe the main necessary modifications needed for the SRF on general compact surfaces and list some open questions.
Humanized Transgenic Mice Are Resistant to Chronic Wasting Disease Prions From Norwegian Reindeer and Moose
Authors: Wadsworth Jonathan D F , Joiner Susan , Linehan Jacqueline M , Jack Kezia , Al-Doujaily Huda , Costa Helena , Ingold Thea , Taema Maged , Zhang Fuquan , Sandberg Malin K , Brandner Sebastian , Tran Linh , Vikøren Turid , Våge Jørn , Madslien Knut , Ytrehus Bjørnar , Benestad Sylvie L , Asante Emmanuel A , Collinge John 
Published: January 2021

Abstract
Chronic wasting disease (CWD) is the transmissible spongiform encephalopathy or prion disease affecting cervids. In 2016, the first cases of CWD were reported in Europe in Norwegian wild reindeer and moose. The origin and zoonotic potential of these new prion isolates remain unknown. In this study to investigate zoonotic potential we inoculated brain tissue from CWD-infected Norwegian reindeer and moose into transgenic mice overexpressing human prion protein. After prolonged postinoculation survival periods no evidence for prion transmission was seen, suggesting that the zoonotic potential of these isolates is low.
Differential impact of on-site or telepharmacy in the intensive care unit: a controlled before–after study
Authors: Ramos Joao Gabriel Rosa , Hernandes Sandra Cristina , Pereira Talita Teles Teixeira , Oliveira Shana , Soares Denis de Melo , Passos Rogerio da Hora , Caldas Juliana Ribeiro , Guarda Suzete Nascimento Farias , Batista Paulo Benigno Pena , Mendes Ana Verena Almeida 
Published: January 2021

Abstract

Background
Clinical pharmacists have an important role in the intensive care unit (ICU) team but are scarce resources. Our aim was to evaluate the impact of on-site pharmacists on medical prescriptions in the ICU.

Methods
This is a retrospective, quasi-experimental, controlled before-after study in two ICUs. Interventions by pharmacists were evaluated in phase 1 (February to November 2016) and phase 2 (February to May 2017) in ICU A (intervention) and ICU B (control). In phase 1, both ICUs had a telepharmacy service in which medical prescriptions were evaluated and interventions were made remotely. In phase 2, an on-site pharmacist was implemented in ICU A, but not in ICU B. We compared the number of interventions that were accepted in phase 1 versus phase 2.

Results
During the study period, 8797/9603 (91.6%) prescriptions were evaluated, and 935 (10.6%) needed intervention. In phase 2, there was an increase in the proportion of interventions that were accepted by the physician in comparison to phase 1 (93.9% versus 76.8%, P &lt; 0.001) in ICU A, but there was no change in ICU B (75.2% versus 73.9%, P = 0.845).

Conclusion
An on-site pharmacist in the ICU was associated with an increase in the proportion of interventions that were accepted by physicians.
Prognostic impact of geriatric assessment in elderly patients with non-small cell lung cancer: an integrated analysis of two randomized phase III trials (JCOG1115-A)
Authors: Katayama Hiroshi , Mizusawa Junki , Fukuda Haruhiko , Nakamura Shinichiro , Nakamura Kenich , Saijo Nagahiro , Yokoyama Akira , Ohe Yuichro , Shinkai Tetsu , Nakagawa Kazuhiko , Abe Tetsuya , Mitsuoka Shigeki , Okamoto Hiroaki , Yamamoto Nobuyuki , Yoshioka Hiroshige , Ando Masahiko , Tamura Tomohide , Takeda Koji 
Published: January 2021

Abstract

Objective
Patients’ actual age and performance status do not always accurately identify the ‘fit elderly’ for chemotherapy. This study aimed to determine whether four geriatric assessment tools could predict prognosis.

Methods
This study were analyzed using the data of two randomized phase III trials (JCOG0207 and JCOG0803/WJOG4307L) for elderly patients with advanced non-small cell lung cancer and included all eligible patients who were assessed before treatment with four geriatric assessment tools: the Barthel activities of daily living index, Lawton instrumental activities of daily living scale, Mini-Mental State Examination, and Geriatric Depression Scale-15. Univariable and multivariable analyses for overall survival, adjusted for baseline factors, were performed using a stratified Cox regression model with treatment regimen as strata.

Results
This analysis included 330 patients aged 70–74, 75–79 or 80 or more (n = 95/181/54), with a performance status of 0 or 1 (n = 119/211). Patients were divided into three groups based on Mini-Mental State Examination and two groups based on Geriatric Depression Scale, but over 80% of patients had perfect scores for both activities of daily living and instrumental activities of daily living. In overall survival subgroup analyses by GA tool, only Mini-Mental State Examination scores were associated with substantial outcome differences (median survival times: 21.2, 13.5 and 12.2 months for scores 30, 29–24 and ≤23). After adjusting for baseline factors, the Mini-Mental State Examination, sex and performance status were tended to be worse overall survival.

Conclusion
MMSE scores, performance status and sex, but not chronological age, effectively predicted the prognosis of elderly patients. Further studies should confirm that the Mini-Mental State Examination is useful for determining the indication of chemotherapy in elderly patients with advanced non-small cell lung cancer.
Family Functioning in Pediatric Functional Gastrointestinal Disorders: A Systematic Review
Authors: Garr Katlyn , Odar Stough Cathleen , Origlio Julianne 
Published: January 2021

Abstract

Objective
Children with some chronic health conditions experience family functioning difficulties. However, research examining family functioning in youth with functional gastrointestinal disorders (FGIDs) has produced mixed results. Therefore, the current review critically synthesized the literature on family functioning among youth with FGIDs.

Methods
A systematic search using pediatric, family functioning, and FGID search terms was conducted in PubMed, PsycInfo, and ProQuest. Out of the 586 articles initially identified, 17 studies met inclusion criteria. Studies were included if they presented original research in English, assessed family functioning, and the study sample consisted of children (0–18 years) diagnosed with a FGID. Quality assessment ratings were conducted for each included study based on a previously developed scientific merit 3-point rating system.

Results
The majority of studies (n = 13) examined family functioning between youth with FGIDs and comparison groups. The remaining studies explored associations between family functioning and study variables (e.g., child psychosocial functioning and sociodemographic factors) and examined family functioning clusters among children with FGIDs. In general, children with FGIDs demonstrated poorer family functioning compared to healthy counterparts. Findings also suggested that child psychosocial functioning, disease characteristics, and sociodemographic factors were related to family functioning among youth with FGIDs. The average quality of studies was moderate (M = 2.3).

Conclusions
Maintaining healthy family functioning appears to be challenging for some families of children with FGIDs. Future research should explore the directionality of the relationship between family functioning and child physical and psychosocial outcomes to advance the understanding and treatment of pediatric FGIDs.
NUPR1 participates in YAP-mediate gastric cancer malignancy and drug resistance via AKT and p21 activation
Authors: Jiang Lei , Wang Wenjun , Li Zhanwu , Zhao Yao , Qin Zhensheng 
Published: January 2021

Abstract

Objectives
To assess nuclear protein 1 (NUPR1) level in human gastric cancer (GC) cells, explore the effects of NUPR1 on GC progression, and investigate the possible regulatory mechanism.

Methods
Immunohistochemistry (IHC), Immunoblot and quantitative PCR assays were conducted to detect the NUPR1 level in human GC tissues and corresponding normal tissues. Also, NUPR1 expression level correlates with clinical features of GC patients. 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT), transwell assays, Immunoblot assays, and flow cytometry (FCM) assays were used to evaluate the effects of NUPR1 on the proliferation, invasion, epithelial-mesenchymal transformation (EMT) and apoptosis of GC cells in vitro. Immunoblot assays were performed to detect the potential mechanism in NUPR1-mediated drug resistance.

Key findings
We found the expression of NUPR1 was upregulated in human gastric cancer tissues and correlated with the clinical features including tumour size, tumour stage and, lymph node metastasis. We further noticed that the depletion of NUPR1 inhibited the invasion and EMT of gastric cancer cells and stimulated the apoptosis. In doxorubicin-resistant gastric cancer cells, yes-associated protein (YAP) activation was up-regulated, and YAP could regulate the expression of NUPR1 to affect drug-resistance. We further provided the evidence that overexpression of NUPR1 reversed the effect of YAP knockdown on cell malignancy and drug resistance via regulating AKT and p21 pathway.

Conclusions
Our findings indicated the involvement of NUPR1 in the progression of gastric cancer and elucidated its molecular mechanism in regulating drug resistance.
Proteomics of developing pea seeds reveals a complex antioxidant network underlying the response to sulfur deficiency and water stress
Authors: Henriet Charlotte , Balliau Thierry , Aimé Delphine , Le Signor Christine , Kreplak Jonathan , Zivy Michel , Gallardo Karine , Vernoud Vanessa 
Published: January 2021

AbstractPea is a legume crop producing protein-rich seeds and is increasingly in demand for human consumption and animal feed. The aim of this study was to explore the proteome of developing pea seeds at three key stages covering embryogenesis, the transition to seed-filling, and the beginning of storage-protein synthesis, and to investigate how the proteome was influenced by S deficiency and water stress, applied either separately or combined. Of the 3184 proteins quantified by shotgun proteomics, 2473 accumulated at particular stages, thus providing insights into the proteome dynamics at these stages. Differential analyses in response to the stresses and inference of a protein network using the whole proteomics dataset identified a cluster of antioxidant proteins (including a glutathione S-transferase, a methionine sulfoxide reductase, and a thioredoxin) possibly involved in maintaining redox homeostasis during early seed development and preventing cellular damage under stress conditions. Integration of the proteomics data with previously obtained transcriptomics data at the transition to seed-filling revealed the transcriptional events associated with the accumulation of the stress-regulated antioxidant proteins. This transcriptional defense response involves genes of sulfate homeostasis and assimilation, thus providing candidates for targeted studies aimed at dissecting the signaling cascade linking S metabolism to antioxidant processes in developing seeds.
A genome-wide association study reveals cytokinin as a major component in the root defense responses againstRalstonia solanacearum
Authors: Alonso-Díaz Alejandro , Satbhai Santosh B , de Pedro-Jové Roger , Berry Hannah M , Göschl Christian , Argueso Cristiana T , Novak Ondrej , Busch Wolfgang , Valls Marc , Coll Núria S 
Published: January 2021

AbstractBacterial wilt caused by the soil-borne pathogen Ralstonia solancearum is economically devastating, with no effective methods to fight the disease. This pathogen invades plants through their roots and colonizes their xylem, clogging the vasculature and causing rapid wilting. Key to preventing colonization are the early defense responses triggered in the host’s root upon infection, which remain mostly unknown. Here, we have taken advantage of a high-throughput in vitro infection system to screen natural variability associated with the root growth inhibition phenotype caused by R. solanacearum in Arabidopsis during the first hours of infection. To analyze the genetic determinants of this trait, we have performed a genome-wide association study, identifying allelic variation at several loci related to cytokinin metabolism, including genes responsible for biosynthesis and degradation of cytokinin. Further, our data clearly demonstrate that cytokinin signaling is induced early during the infection process and cytokinin contributes to immunity against R. solanacearum. This study highlights a new role for cytokinin in root immunity, paving the way for future research that will help in understanding the mechanisms underpinning root defenses.