bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entailment of the academic offer and National Planning of Ecuador Development
Authors: Ordóñez Parra Janice , Morocho Macas Ángel Aurelio , Sarmiento Espinoza William , Bonilla Sonia Marlene 
Published: September 2021

The university maintains interactions between social formation processes and society; as an institution, it is regulated by state regulatory entities that promote significant institutional transformations that force them to adapt to constitutional, legal and planning requirements. The objective of this research is to analyze the entailment between the accounting training of the Accounting and Audit program of the Universidad Católica de Cuenca and the National Development Plan 2017-2021 of Ecuador. For this, the interpretive hermeneutical method was used, through the bibliographic and documentary review. The results show the objectives, challenges and initiatives related to the accounting profession; the needs and goals of the problems to study, intervene and transform, the basic disciplinary cores of the program, and the link between them. It is concluded that there is a link between the context and the objectives of the National Development Plan and the professional training offered; distinguishing problems such as the difficulty of access to education, participation in the productive sector, the lack of technical advice, investment, motivation and institutional trust as significant challenges faced with the disciplinary cores of accounting and finance, regulation and control, administrative and economic sciences.
La Evaluación Intermedia de la Licenciatura en Sistemas Computacionales de la Universidad Autónoma de Nayarit
Authors: Benítez Cortés Rubén Paúl , Aguilar Navarrete Perla , Cruz Sánchez Eligardo , Camacho González María Francisca Yolanda , Torres Covarrubias Víctor Javier 
Published: September 2021

Este trabajo tiene como propósito exponer los avances logrados por los académicos de la Licenciatura en Sistemas Computacionales de la Universidad Autónoma de Nayarit en el proceso institucional de Evaluación Intermedia. Específicamente, se exponen mejoras al instrumento de evaluación y al proceso de implementación respecto a la primera evaluación ocurrida en mayo de 2015.
This paper aims to present the progress made by scholars of the Bachelor of Computer Systems of the Universidad Autónoma de Nayarit in the institutional process of intermediate evaluation. Specifically, improvements are exposed to the assessment tool and implementation process regarding the first evaluation that took place in May 2015.
KEBERHASILAN PEMERANGKAPAN TIKUS (Rattus exulans) DENGAN JENIS UMPAN BERBEDA DI KEBUN RAYA LIWA LAMPUNG BARAT
Authors: Gumay Destika Putri , Kanedi Mohammad , Setyaningrum Endah , Busman Hendri 
Published: September 2021

Tikus merupakan hewan liar yang mampu beradaptasi dengan kehidupan manusia. Tikus juga menjadi hama penting dalam kehidupan manusia, baik dalam bidang pertanian, perkebunan, permukiman, dan kesehatan. Tikus digolongkan ke dalam Ordo Rodentia dan Famili Muridae.Penelitian ini bertujuan untuk mengetahui tingkat keberhasilan pemerangkapan tikus menggunakan empat jenis umpan yang berbeda berupa kelapa bakar, ikan asin, tulang ayam dan ubi jalar dengan meggunakan perangkap hidup tunggal (single live trap). Penelitian ini dilakukan di Kebun Raya Liwa Lampung Barat pada tanggal 17-26 Oktober 2019. Total perangkap yang digunakan adalah 8 perangkap dalam sekali pemasangan dengan total 10 kali pemasangan perangkap. Pengamatan yang dilakukan adalah jumlah tikus terperangkap, jenis tikus yang terperangkap, jenis kelamin dan ukuran tikus, serta umpan yang paling banyak menarik tikus sehingga terperangkap. Hasil penelitian ini adalah keberhasilan pemerangkapan (KP) tikus dengan jenis umpan yang berbeda. Tikus lebih menyukai umpan kelapa bakar dengan keberhasilan pemerangkapan paling tinggi yaitu 87,5 %. Spesies yang terperangkap adalah (Rattus exulans) tikus ladang, (Suncus murinus) cecurut rumah dan (Hylomys suillus) cecurut babi. Tikus dengan jenis kelamin betina lebih banyak didapat (8 ekor) dibandingkan tikus jantan (3 ekor). Tikus dengan ukuran <70 gr lebih banyak didapat (8 ekor) dibandingkan dengan ukuran >70 gr (3 ekor).
Економічні ефекти прямого іноземного інвестування на ринки приймаючих країн
Authors: Михальченко І. Г. 
Published: September 2021

У глобальних умовах розвитку пряме іноземне інвестування відіграє ключову роль для країн, що розвиваються, оскільки впливає на їх економічний розвиток та структурні реформи. Головними інвесторами на ринку приймаючих країн є транснаціональні корпорації, країнами базування яких є країни високого рівня розвитку. Актуальним вважаємо питання моделювання загального впливу прямого інвестування на секторальні ринки приймаючих країн у цілому.
Метою статті є діагностика безпосередніх та другорядних економічних ефектів прямого інвестування на ринки приймаючих країн.
Методи дослідження включають методи наукового узагальнення, спостереження, синтезу для виявлення ключових факторів впливу прямого іноземного інвестування; статистичні та аналітичні методи узагальнення інформації; моделювання – для встановлення функціональних взаємозв’язків економічних ефектів прямого інвестування ТНК та підвищення у цілому економічного добробуту ринкового приймаючого сектору.
Результати статті полягають у теоретичному узагальненні принципів впливу ТНК на ринки приймаючих країн. Надано спробу розробити модель впливу прямого інвестування на приймаючий ринок з урахуванням прямих та другорядних ефектів. Проаналізовано вплив ТНК на економічне зростання України на прикладі ТНК «Coca-Cola». Інвестиції «Coca-Cola» у місцеве виробництво сприяли розвитку харчового сектору в Україні.
Результати дослідження довели, що пряме інвестування здійснює позитивний вплив від безпосередньої діяльності компанії, підвищує економічне зростання супутніх підприємств на ринку, які виступають її торговельними партнерами та постачальниками. Отже, відбувається зростання всього ринкового сектору, куди направляються інвестиції. ТНК як основні вкладники у розвиваючі ринки приймаючих країн позитивно впливають на її економічний розвиток, підвищуючи рівень ВВП, забезпечуючи робочими місцями, здійснюючи регулярні податкові платежі та підвищуючи доходи громадян, що безпосередньо продемонстровано в результаті аналізу діяльності «Coca-Cola» в Україні.
Investigação das alterações na percepção temporal pela presença de altos níveis de dependência de smartphone
Authors: Castellon Luís Augusto Soares , Cavalcanti Jonathan Bento , Souza Renato Américo Dantas Camilo de , Dantas Fábio Galvão 
Published: September 2021

Objetivo: Investigou-se a correlação entre a construção da percepção do tempo e de altos níveis de dependência de Smartphone, em estudantes universitários de Campina Grande - PB. Metodologia: Estudo descritivo na área de psicologia cognitiva, de natureza quantitativa e experimental. A pesquisa foi realizada de forma virtual, na plataforma Google Forms, pela aplicação de I-) Questionário socioeconômico; II-) Escala de Dependência de Smartphone (EDS); III-) Apresentação de estímulo padronizado (466 segundos); IV-) Questionário sobre a percepção do estímulo. As variáveis foram analisadas no programa Statistical Package for the Social Sciences (SPSS) – versão 20.0. Resultados: Participaram da pesquisa 155 estudantes, sendo 115 do gênero feminino (74,2%) e 40 do masculino (25,8%), com a média de idade de 21,5 anos. Para fins deste artigo, comparou-se o grupo sem dependência com o que apresentou alto nível de dependência. Através da EDS, observou-se que 41 (26,45%) dos participantes não apresentaram dependência de Smartphone e 33 (21,29%) apresentaram alto nível. A estimativa média do grupo sem dependência foi de 409s para o estímulo apresentado, enquanto a do grupo com alto nível de dependência foi de 523s (27,8% maior). O teste exato de Fisher indica correlação significativa (X²(4) = 20,373, p < 0,001) entre a percepção da duração do tempo do estímulo e alto nível de dependência de Smartphone. Conclusão: O grupo com alto nível de dependência de Smartphone apresentou percepção aumentada de duração do tempo em relação ao grupo sem dependência.
Expanding the possibilities of migraine attack relief: effcacy and safety of zolmitriptan and patient reports
Authors: Latysheva N. V. , Filatova E. G. , Berdnikova A. V. 
Published: September 2021

A large number of patients are taking triptans due to ineffectiveness or contraindications to the use of non-steroidal anti-inﬂammatory drugs.Aim. Study of the effcacy and safety of Zolmitriptan-SZ, as well as its comparative analysis with other drugs for the relief of migraine attacks based on patient self-reports.Materials and methods. In an open, uncontrolled post-marketing observational study of the effcacy and safety of Zolmitripan-SZ for the relief of migraine attacks, 50 patients with migraine were included. All patients were given questionnaires to collect demographic and health information, as well as a diary for two migraine attacks.Results. The average age of the participants was 40.3 ± 8.5 years (89.5 % were women, 10.5 % were men). After 1 hour, the pain stopped completely in 26.4 % of attacks, after 2 hours – in 78.0 %. Taking into account the return of headache in some patients, after 24 hours 65.9% patients were headache-free. There was also a signifcant reduction in the prevalence of nausea and photo-, phonophobia. Patients reported good effect in 59.6% of attacks and excellent effect in 24.7% of attacks.Conclusion. Conclusion: Zolmitriptan SZ provides safe and effective migraine attack relief.
Evaluation of platelet parameters in cerebral stroke in patients with HIV infection
Authors: Tarasov D. O. , Lebedev I. A. , Suplotov S. N. , Nesterova O. A. , Tersenov G. O. , Werbach T. E. 
Published: September 2021

The article reﬂects the results of studying platelet parameters in HIV-positive patients with different types of stroke.Aim. To identify changes in laboratory parameters of a complete blood count which characterize the morphofunctional features of platelets in stroke among HIV-positive patients.Materials and methods. 110 HIV-positive patients who received treatment for stroke in hospitals of the Tyumen region were examined. The study of blood parameters was carried out at the analyzer Sysmex XE2100 (Japan). Blood sampling was carried out on the day of patients admission.The number of platelets and platelet indices were analyzed: MPV – mean platelet volume, PDW – platelet distribution width, PCT – plateletcrit and P-LCR – platelet large cell ratio. The control group consisted of 117 patients. The signifcance of the differences was determined at the twotailed signifcance level of p < 0.05.Results. There was a signifcant decrease in the number of platelets (p < 0.05), in average, on 34.3% among patients with hemorrhages and HIV infection. Among patients with ischemic stroke this decrease was less pronounced (p = 0.05). A signifcant decrease in plateletcrit was established among patients with intracranial hemorrhages, while it did not change signifcantly among patients with cerebral infarction. During evaluation of other platelet parameters, no signifcant differences were found between patients in experimental and control groups. The coeffcient of giant platelets prevailed by one and a half times in patients with hemorrhages associated with HIV infection, which turned out to be beyond the statistical signifcance.Conclusion. The presence of HIV infection leads to a more pronounced, reliable decrease in the number of platelets and plateletcrit among patients that have acute phase of the development of hemorrhagic stroke than in patients with cerebral infarction. The development of intracranial hemorrhage among HIV-positive patients is characterized by an increase of blood platelets with a high volume, the level of which increased by one and a half times being beyond the statistical signifcance and having as a leading mechanism the intensifcation of platelet formation in the bone marrow.
All-Inorganic p−n Heterojunction Solar Cells by Solution Combustion Synthesis Using N-type FeMnO3 Perovskite Photoactive Layer
Authors: Papadas Ioannis T. , Ioakeimidis Apostolos , Vamvasakis Ioannis , Eleftheriou Polyvios , Armatas Gerasimos S. , Choulis Stelios A. 
Published: September 2021

This study outlines the synthesis and physicochemical characteristics of a solution-processable iron manganite (FeMnO3) nanoparticles via a chemical combustion method using tartaric acid as a fuel whilst demonstrating the performance of this material as a n-type photoactive layer in all-oxide solar cells. It is shown that the solution combustion synthesis (SCS) method enables the formation of pure crystal phase FeMnO3 with controllable particle size. XRD pattern and morphology images from TEM confirm the purity of FeMnO3 phase and the relatively small crystallite size (∼13 nm), firstly reported in the literature. Moreover, to assemble a network of connected FeMnO3 nanoparticles, β-alanine was used as a capping agent and dimethylformamide (DMF) as a polar aprotic solvent for the colloidal dispersion of FeMnO3 NPs. This procedure yields a ∼500 nm thick FeMnO3 n-type photoactive layer. The proposed method is crucial to obtain functional solution processed NiO/FeMnO3 heterojunction inorganic photovoltaics. Photovoltaic performance and solar cell device limitations of the NiO/FeMnO3-based heterojunction solar cells are presented.
Risk Factors for Anthracycline-Induced Cardiotoxicity
Authors: Qiu Shuo , Zhou Tian , Qiu Bo , Zhang Yuxin , Zhou Yonggang , Yu Huihui , Zhang Jingyi , Liu Li , Yuan Lijun , Yang Guodong , Duan Yunyou , Xing Changyang 
Published: September 2021

Background: Several cardiovascular risk factors have been suggested to be associated with anthracycline-induced cardiotoxicity, but their quantitative effects have not reached a consensus.Methods: We searched PubMed, EMBASE, and Cochrane Library databases for manuscripts published from inception to February 2021, which reported the results of cardiotoxicity due to anthracycline chemotherapy without trastuzumab. Cardiotoxicity defined by any reduction of left ventricular eject fraction (LVEF) to below 50% or a &gt;10% reduction from baseline was defined as the primary endpoint. Odd ratios (OR) with 95% confidence intervals (CI) were calculated using a random-effects model meta-analysis.Results: A total of 7,488 patients receiving anthracycline chemotherapy without trastuzumab were included, who had at least one risk factor at baseline. Hypertension (OR: 1.99; 95% CI: 1.43–2.76), diabetes mellitus (OR: 1.74; 95% CI: 1.11–2.74), and obesity (OR: 1.72; 95% CI: 1.13–2.61) were associated with increased risk of cardiotoxicity. In addition, the relative reduction of global longitudinal strain (GLS) from baseline after anthracycline treatment could significantly improve the detection ability of cardiotoxicity (28.5%, 95% CI: 22.1–35.8% vs. 16.4%, 95% CI: 13.4–19.9%) compared with LVEF. The early detection rate of anthracycline-induced cardiotoxicity (3 months after chemotherapy) by GLS was 30.2% (95% CI: 24.9–36.1%), which is similar with the overall result of GLS.Conclusions: Hypertension, diabetes mellitus, and obesity are associated with increased risk of anthracycline-induced cardiotoxicity, which indicates that corresponding protective strategies should be used during and after anthracycline treatment. The findings of higher detection rate and better early detection ability for cardiotoxicity than LVEF added new proofs for the advantages of GLS in detection of AIC.
MIRAGE Syndrome Caused by a De Novo c.3406G>C (p. Glu1136Gln) Mutation in the SAMD9 Gene Presenting With Neonatal Adrenal Insufficiency and Recurrent Intussusception: A Case Report
Authors: Chin Xinyi , Sreedharan Aravind Venkatesh , Tan Ene Choo , Wei Heming , Kuan Jyn Ling , Ho Christopher Wen Wei , Lam Joyce Ching Mei , Ting Teck Wah , Vasanwala Rashida Farhad 
Published: September 2021

IntroductionPrimary adrenal insufficiency (PAI) presenting in the neonatal period can be life threatening and requires early recognition, diagnosis, and management. PAI due to adrenal hypoplasia (syndromic/non-syndromic) is a rare disorder. MIRAGE is a recently described syndrome with PAI and multisystem involvement.Case PresentationA preterm female neonate presenting with PAI and persistent severe thrombocytopenia was diagnosed to have MIRAGE syndrome due to a de novo pathogenic variant c.3406G&gt;C (p. Glu1136Gln) in the SAMD9 gene. In the first year of life, she had recurrent respiratory and gastrointestinal infection causing failure to thrive. At 17 months, she suffered recurrent intussusception requiring treatment with parenteral nutrition and high-dose steroids. Subsequently, she established oral feeds with hydrolysed formula and demonstrated good weight gain.ConclusionIn neonates presenting with PAI and associated multisystem involvement, a thoughtful approach and genetic testing is valuable in discerning an etiological diagnosis. This case of MIRAGE adds to the spectrum of reported cases and is the first to report on recurrent intussusception and its management with high-dose steroids.
Identification of Gene Signature as Diagnostic and Prognostic Blood Biomarker for Early Hepatocellular Carcinoma Using Integrated Cross-Species Transcriptomic and Network Analyses
Authors: Al-Harazi Olfat , Kaya Ibrahim H. , Al-Eid Maha , Alfantoukh Lina , Al Zahrani Ali Saeed , Al Sebayel Mohammed , Kaya Namik , Colak Dilek 
Published: September 2021

Background: Hepatocellular carcinoma (HCC) is considered the most common type of liver cancer and the fourth leading cause of cancer-related deaths in the world. Since the disease is usually diagnosed at advanced stages, it has poor prognosis. Therefore, reliable biomarkers are urgently needed for early diagnosis and prognostic assessment.Methods: We used genome-wide gene expression profiling datasets from human and rat early HCC (eHCC) samples to perform integrated genomic and network-based analyses, and discovered gene markers that are expressed in blood and conserved in both species. We then used independent gene expression profiling datasets for peripheral blood mononuclear cells (PBMCs) for eHCC patients and from The Cancer Genome Atlas (TCGA) database to estimate the diagnostic and prognostic performance of the identified gene signature. Furthermore, we performed functional enrichment, interaction networks and pathway analyses.Results: We identified 41 significant genes that are expressed in blood and conserved across species in eHCC. We used comprehensive clinical data from over 600 patients with HCC to verify the diagnostic and prognostic value of 41-gene-signature. We developed a prognostic model and a risk score using the 41-geneset that showed that a high prognostic index is linked to a worse disease outcome. Furthermore, our 41-gene signature predicted disease outcome independently of other clinical factors in multivariate regression analysis. Our data reveals a number of cancer-related pathways and hub genes, including EIF4E, H2AFX, CREB1, GSK3B, TGFBR1, and CCNA2, that may be essential for eHCC progression and confirm our gene signature’s ability to detect the disease in its early stages in patients’ biological fluids instead of invasive procedures and its prognostic potential.Conclusion: Our findings indicate that integrated cross-species genomic and network analysis may provide reliable markers that are associated with eHCC that may lead to better diagnosis, prognosis, and treatment options.
Transcriptome Profiling Reveals Important Transcription Factors and Biological Processes in Skin Regeneration Mediated by Mechanical Stretch
Authors: Liu Wei , Xiong Shaoheng , Zhang Yu , Du Jing , Dong Chen , Yu Zhou , Ma Xianjie 
Published: September 2021

Background: Mechanical stretch is utilized to promote skin regeneration during tissue expansion for reconstructive surgery. Although mechanical stretch induces characteristic morphological changes in the skin, the biological processes and molecular mechanisms involved in mechanically induced skin regeneration are not well elucidated.Methods: A male rat scalp expansion model was established and the important biological processes related to mechanical stretch-induced skin regeneration were identified using Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and gene set enrichment analysis (GSEA). Analysis was also conducted by constructing a protein–protein interaction (PPI) network, identifying key modules and hub genes, determining transcription factor (TF)-mRNA regulatory relationships, and confirming the expression pattern of the TFs and hub genes.Results: We identified nine robust hub genes (CXCL1, NEB, ACTN3, MYOZ1, ACTA1, TNNT3, PYGM, AMPD1, and CKM) that may serve as key molecules in skin growth. These genes were determined to be involved in several important biological processes, including keratinocyte differentiation, cytoskeleton reorganization, chemokine signaling pathway, glycogen metabolism, and voltage-gated ion channel activity. The potentially significant pathways, including the glucagon signaling pathway, the Wnt signaling pathway, and cytokine–cytokine receptor interaction, were distinguished. In addition, we identified six TFs (LEF1, TCF7, HMGA1, TFAP2C, FOSL1, and ELF5) and constructed regulatory TF–mRNA interaction networks.Conclusion: This study generated a comprehensive overview of the gene networks underlying mechanically induced skin regeneration. The functions of these key genes and the pathways in which they participate may reveal new aspects of skin regeneration under mechanical strain. Furthermore, the identified TF regulators can be used as potential candidates for clinical therapeutics for skin pretreatment before reconstructive surgery.
Why Are Newcomers so Happy? Subjective Well-Being of First-Generation Immigrants in Germany
Authors: Brockmann Hilke 
Published: September 2021

First-generation immigrants are surprisingly satisfied with their life compared to the local population in Germany. Is this because newcomers are particularly resourceful? We test if personality selectivity, purposive adaptation, and social resilience separately or in tandem explain why subjective well-being remains high even in times of objective disadvantage. Using German panel data (GSOEP) from 5,008 first-generation immigrants for the years 1984–2014 and official data, growth curve models show that newcomers are a selected group with respect to their open and less neurotic personalities and that these personal characteristics are distinctly associated with happiness. Also, newcomers immediately compare their income to the standards in the host society but not their family life. This contributes to boosting their subjective well-being as well. For more than 30 years, first-generation immigrants use their country of origin as a reference point thus protecting the positive association of intimate relationships and happiness. Finally, newcomers are highly capable of recovering from social loss. Since the resources used by first-generation migrants to preserve their subjective well-being are unlikely to be confined to Germany, our findings can inform policy-making. Most importantly, they suggest that the economic integration of newcomers should be fast and easy while family reunification and integration should follow only with a time lag.