bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost Benefit dan Effectiveness Investasi Alat Kesehatan Berteknologi Tinggi di Instalasi Radiologi
Authors: Udyanto Hari Mukti 
Published: June 2021

<p><em>One of the important components supporting the effort to cure patients is medical devices. Hermina Mekarsari Hospital type C classification seeks to meet services in accordance with service standards. Preliminary monitoring data found that the CT - Scan examination room facilities in the Radiology Installation have not been used as intended. This is because the medical equipment investment process is not optimal, the financial sector is not involved, so no investment analysis is conducted. The research objective was to analyze the investment feasibility and investment planning process of two CT-Scan and 3D / 4D ultrasound medical devices in Radiology Installation. Research is an empirical study with quantitative methods. The aim is to obtain more in-depth information about the planning process for high-tech and expensive medical equipment. A total of 6 informants as parties involved in the investment process. The results of the study for CT-Scan and 3D / 4D ultrasound, based on NPV calculations are positive, IRR values are lower than the interest rates used, CBR values are more than 1, and PI values are more than 1. It was concluded that from the analysis of financial aspects for investment in both medical devices is worth the investment. It is recommended that hospitals immediately hold the two medical devices in 2020 or 2021.</em></p>
Tingkat Kebahagiaan Masyarakat setelah Adanya Mural di Kelurahan Sukawarna Kecamatan Sukajadi Bandung
Authors: Pandanwangi Ariesa , Ida Ida , Ratnadewi Ratnadewi , Manurung Rosida Tiurma , Budiman Iman , Vincent Vincent 
Published: June 2021

Abstrak
Tujuan penelitian ini yaitu untuk mengukur tingkat kebahagiaan masyarakat Kelurahan Sukawarna setelah dibuatnya mural di lingkungan mereka. Metode yang digunakan adalah metode campuran (mix method). Pertama metode penelitian berbasis komunitas dan kedua menggunakan survei. Hasil penelitian ini menunjukkan pertama, masyarakat berhasil membuat karya mural dengan tema kearifan lokal berupa benda-benda hunian, flora, dan fauna yang diwarnai. Secara estetika, visualisasi dinding menjadi menarik, sehingga lingkungan menjadi menarik dan orang dapat mengambil foto diri di sana. Kedua, berdasarkan survei dengan adanya mural mempengaruhi tingkat kebahagiaan masyarakat sebesar 49,9 %
Abstract
Environmental problems, one of which is the space for the actuality of citizens. The mural is one of the attractive locations for environmental attraction and can be a marker of an urban area. At present RW 04 Sukawarna Urban Village has not been well organized, so it requires a colorful environment that can be one of the interesting areas in Bandung. This service is guided by the facilitator with the principle of partnership assistance with the Asset Based Community. Development method. The community service servants will complete a 12 meter long wall with a height of 3 m. The wall will be painted on and given color. The result of this service is a mural work with the theme of local wisdom in the form of objects of residential objects, flora and fauna that are colored. Aesthetically, the visualization of the walls becomes interesting, so the environment becomes interesting, and people can take self-photographs there. Economically, the environment can be an attraction and an incentive for tourists who come gradually, so that the community can empower economic growth in the future.
Composição corporal e desempenho físico de escolares em instituições distintas
Authors: Martinez Caroline Sirí­aco , Madureira Fabricio , Mineiro Aurea dos Santos , Souza Ivanildo Alves de , Santos Roberto Melchior Soares dos , Guedes Jr Dilmar Pinto , Colantonio Emilson , Silva Rodrigo Pereira da 
Published: June 2021

Introdução: O avanço tecnológico, a má alimentação e a inatividade física são alguns dos responsáveis pelo aumento no número de crianças que apresentam doenças de caráter crônico degenerativas, problema atual de saúde pública em diferentes instituições de ensino particular e público. Objetivo: Analisar, classificar e comparar a composição corporal e desempenho físico de escolares de instituições da rede privada e pública de uma cidade litorânea paulista. Métodos: Foram avaliadas 117 crianças, 58 voluntários de escolas públicas e 59 voluntários de escola particular com idade entre 8 e 11 anos. Foram realizadas as seguintes avaliações: antropometria: massa corporal, estatura, índice de massa corpórea (IMC), e percentual de gordura corporal (%GC) obtido por meio da utilização da medida das dobras cutâneas (tricipital e subescapular). Desempenho físico: flexibilidade, força de preensão manual, força e resistência abdominal. Análise estatística: após a confirmação da não normalidade dos dados, optou-se pelo teste de Mann- -Whitney U para comparação entre os grupos e o teste t Student para comparação entre o valor obtido e normativo de referência. Resultados: As crianças da escola privada quando comparadas às da escola pública revelaram diferenças estatísticas significativas para IMC, %GC, força de preensão manual e força e resistência abdominal. Conclusão: Esses achados denotam valores elevados em relação aos valores de referência para as variáveis antropométricas e valores abaixo dos valores de referência para as variáveis de desempenho físico, o que pode ser prejudicial à saúde de crianças em fase de crescimento e desenvolvimento.
Coercion or Cost-Decrease: Why Do Firms Pay Influences?
Authors: Israel Odion E. Idewele  , Peter Eriki  , Murad A. Bein  
Published: June 2021

It has been observed that Firms Influence Government Authorities by paying Bribe to them. This paper examines how gift is related with the potential for the firm to discover legitimate government authorities. This paper attempts to ascertain why firms pay bribes. More specifically, does it appear that firms are being extorted or is it more likely that they are using bribes as a tool to avoid regulation? In the event that organizations that report more prominent chances to discover government authority pay bribe, at that point this is an indication that rewards originated from coercion in light of the fact that the nearness of such authorities ought not make any difference for firms needing to pay bribe to reduced costs. We find out that influences emerge because of coercion in spite of the fact that result fairly debilitate in the most current study. If corrupt individuals are more likely to enter into environments that allow them to extract bribes, then honest could be endogenous and driven by the prevalence and magnitude of bribery.
MODERN GEORGIAN COMPARATIVE STUDIES: DIRECTIONS OF RESEARCH, MAIN ISSUES
Authors: Hrytsyk Liudmyla , Mchedeladze Ivane 
Published: June 2021

Taking into account the factual material, research methods, and tasks, the authors trace the evolution/changes in Georgian comparative studies. It is notable that typological approaches, along with contact-genetic ones, are now actively used. These changes become firmly established due to the studies of iconic figures and periods, which attract the special attention of the scholars. Eurocentric concepts give place to other ones that have their basis in the study of the national literature and include philosophical, anthropological, psychological, and religious factors in the field of research. A lot of attention has been given to the principles of selecting literary texts for translation. The field of Georgian comparative studies has been remarkably changed/updated in the late 20th — early 21st centuries. Along with historians of literature, the theorists, critics, translators, and specialists in European and Oriental languages have been involved, which affected the level of comparative studies. Among the raised issues are reception, imagology, typology of anti-colonial narratives, genre transformations, postmodern discourse, etc. The character of Georgian-Ukrainian comparative studies changed drastically: it is obvious in the approaches/assessments of literary translation and in all connecting issues in general. Comparative studies came as close as possible to the theory of literature, which let the researchers (R. Khvedelidze, N. Naskidashvili, S. Chkhatarashvili, I. Mchedeladze) update the methodology and intensify their work on the diff erent levels of research, regardless of the presence/absence of contexts. The present surge in Georgian comparative studies started in the 2010s. It is connected to the organization of effective specialized research centers. Of great interest are the comparative studies aiming to show the history of Georgian literature as an individual version of the world literature (I. Ratiani), to identify the features of the Georgian literary canon based on the three main literary models (Middle Ages, Romanticism, post-Soviet), with a focus on the combination of ‘canonical’ and ‘non-canonical’ in innovative writing.
SOME ISSUES ON PROTECTION OF NATIONAL INTERESTS CONCEMING INTELLECTUAL PROPERTY IN THE PROCESS OF EURO-ATLANTIC INTEGRATION
Authors: Олександр Зайківський  , Олександр Оністрат  
Published: June 2021

Some issues of protection of national interests concerning intellectual property in the process of Euro-Atlantic integration are considered, in particular features of protection of intellectual property in the implementation of international military-technical cooperationof Ukraine, depending on the specifics of this activity. The legislation of Ukraine regulating activities related to military-technical cooperation is analyzed. The importance of intellectual property protection at all stages of military-technical cooperation and the need to improve the legislation on the regulation of intellectual property protection in the defense sphere are outlined.The Constitution and major legislative acts of Ukraine in the field of national security and defense have clearly defined the strategic course for achieving NATO membership. However, to achieve this strategic goal requires persistence and political will, as well as an understanding of the various tactical issues that need to be resolved along the way.New members are being trained in the process of performing the NATO Membership Action Plan. On the long-term path of Euro-Atlantic integration, Ukraine has developed an annual NATO-Ukraine national program. Traditionally, the Annual National Program is structurally constructed by analogy with a typical Membership Action Plan andincludes almost all areas of reformation and modernization of Ukraine.In particular, great attention is paid to reforming and comprehensive support of Ukraine's security and defense sector. It includes a wide range of measures to maintain combat capabilities, modernize and upgrade weapons and military equipment, reform and develop the defense-industrial complex of Ukraine, implement the government qualityassurance system of defense products, revitalize the scientific and military-technical cooperation. Even measures to ensure gender equality in the security and defense sector of Ukraine are being envisaged.It is stated that defense and technical cooperation with NATO will be focused, in particular, on the use of the best modern world technologies. However, the issues of intellectual property protection of all entities and protection of national interests in this field are not considered at all, although almost all the envisaged measures cannot be implementedwithout the use of intellectual property rights.In our view, intellectual property issues should be decided in conjunction with other issues. However, in order to determine the position of the state and development of appropriate proposals and recommendations for securing national interests in intellectual property in the process of Euro-Atlantic integration, it is appropriate to consider these issuesin the following areas: legal cooperation between Ukraine and NATO;scientific cooperation; military-technical cooperation.
Serum Complement C3 and C4 and COVID-19 Severity and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression
Authors: Zinellu Angelo , Mangoni Arduino A. 
Published: June 2021

Activation of the complement system has been observed in coronavirus disease 19 (COVID-19). We conducted a systematic review and meta-analysis with meta-regression to investigate possible differences in the serum concentrations of two routinely measured complement components, C3 and C4, in COVID-19 patients with different severity and survival status. We searched PubMed, Web of Science and Scopus, between January 2020 and February 2021, for studies reporting serum complement C3 and C4, measures of COVID-19 severity, and survival. Eligibility criteria were a) reporting continuous data on serum C3 and C4 concentrations in COVID-19 patients, -b) investigating COVID-19 patients with different disease severity and/or survival status, c) adult patients, d) English language, e) ≥10 patients, and f) full-text available. Using a random-effects model, standardized mean differences (SMD) with 95% confidence intervals (CIs) were calculated to evaluate differences in serum C3 and C4 concentrations between COVID-19 patients with low vs. high severity or survivor vs. non-survivor status. Risk of bias was assessed using the Newcastle-Ottawa scale whereas publication bias was assessed with the Begg’s and Egger’s tests. Certainty of evidence was assessed using GRADE. Nineteen studies in 3,764 COVID-19 patients were included in the meta-analysis. Both C3 and C4 concentrations were significantly lower in patients with high disease severity or non-survivor status than patients with low severity or survivor status (C3 SMD=-0.40, 95% CI -0.60 to -0.21, p&lt;0.001; C4 SMD=-0.29, 95% CI -0.49 to -0.09, p=0.005; moderate certainty of evidence). Extreme between-study heterogeneity was observed (C3, I2 = 82.1%; C4, I2 = 84.4%). Sensitivity analysis, performed by sequentially removing each study and re-assessing the pooled estimates, showed that the magnitude and direction of the effect size was not modified. There was no publication bias. In meta-regression, the SMD of C3 was significantly associated with white blood cell count, C-reactive protein (CRP), and pro-thrombin time, whereas the SMD of C4 was significantly associated with CRP, pro-thrombin time, D-dimer, and albumin. In conclusion, lower concentrations of C3 and C4, indicating complement activation, were significantly associated with higher COVID-19 severity and mortality. C3 and C4 might be useful to predict adverse clinical consequences in these patients.Systematic Review Registration: PROSPERO, Registration number: CRD42021239634.
Altered Functional Connectivity and Cognition Persists 4 Years After a Transient Ischemic Attack or Minor Stroke
Authors: Nicolas Korinne , Goodin Peter , Visser Milanka M. , Michie Patricia T. , Bivard Andrew , Levi Christopher , Parsons Mark W. , Karayanidis Frini 
Published: June 2021

Background and Purpose: Altered executive functions and resting-state functional connectivity (rsFC) are common following a minor stroke or transient ischemic attack (TIA). However, the long-term persistence of these abnormalities is not well-studied. We investigated whether there were cognitive and rsFC differences between (a) controls and minor cerebrovascular event (CVE) patients and (b) between CVE patients with and without an imaging confirmed infarct (i.e., minor stroke and TIA, respectively) at an average of 3.8 years following their event.Methods: Structural and resting-state imaging and cognitive assessments including the Montreal Cognitive Assessment, the Trail Making Task and the National Institute of Health (NIH) Cognition Toolbox were conducted on 42 patients (minor stroke = 17, TIA = 25) and 20 healthy controls (total N = 62).Results: Controls performed better than patients on two measures of executive functioning (both p &lt; 0.046) and had reduced rsFC between the frontoparietal and default mode networks (FPN and DMN, respectively; p = 0.035). No cognitive differences were found between minor stroke and TIA patients, however, rsFC differences were found within the FPN and the DMN (both p &lt; 0.013). Specifically, increased connectivity within the FPN was associated with faster performance in the minor stroke group but not the TIA group (p = 0.047).Conclusions: These findings suggest that transient or relatively minor cerebrovascular events are associated with persistent disruption of functional connectivity of neural networks and cognitive performance. These findings suggest a need for novel interventions beyond secondary prevention to reduce the risk of persistent cognitive deficits.
Anticoagulation Therapy Reduces Recurrent Stroke in Embolic Stroke of Undetermined Source Patients With Elevated Coagulation Markers or Severe Left Atrial Enlargement
Authors: Patel Kishan , Mikhael Elio , Liu Michael , Rangaraju Srikant , Ellis Deandra , Duncan Alexander , Belagaje Samir , Belair Trina , Henriquez Laura , Nahab Fadi 
Published: June 2021

Background: The objective of this study was to evaluate if anticoagulation therapy reduces recurrent stroke in embolic stroke of undetermined source (ESUS) patients with left atrial enlargement (LAE) or abnormal markers of coagulation and hemostatic activity (MOCHA) compared to antiplatelet therapy.Methods: ESUS patients from January 1, 2017, to June 30, 2019, underwent outpatient cardiac monitoring and the MOCHA profile (serum d-dimer, prothrombin fragment 1.2, thrombin–antithrombin complex, and fibrin monomer). Anticoagulation was offered to patients with abnormal MOCHA (≥2 elevated markers) or left atrial volume index 40 mL/m2. Patients were evaluated for recurrent stroke or major hemorrhage at routine clinical follow-up. We compared this patient cohort (cohort 2) to a historical cohort (cohort 1) who underwent the same protocol but remained on antiplatelet therapy.Results: Baseline characteristics in cohort 2 (n = 196; mean age = 63 ± 16 years, 59% female, 49% non-White) were similar to cohort 1 (n = 42) except that cohort 2 had less diabetes (43 vs. 24%, p = 0.01) and more tobacco use (26 vs. 43%, p = 0.04). Overall, 45 patients (23%) in cohort 2 initiated anticoagulation based on abnormal MOCHA or LAE. During mean follow-up of 13 ± 10 months, cohort 2 had significantly lower recurrent stroke rates than cohort 1 (14 vs. 3%, p = 0.009) with no major hemorrhages.Conclusions: Anticoagulation therapy in a subgroup of ESUS patients with abnormal MOCHA or severe LAE may be associated with a reduced rate of recurrent stroke compared to antiplatelet therapy. A prospective, randomized study is warranted to validate these results.
WRN Germline Mutation Is the Likely Inherited Etiology of Various Cancer Types in One Iranian Family
Authors: Norouzi Mahnaz , Shafiei Mohammad , Abdollahi Zeinab , Miar Paniz , Galehdari Hamid , Emami Mohammad Hasan , Zeinalian Mehrdad , Tabatabaiefar Mohammad Amin 
Published: June 2021

BackgroundFamilial cancers comprise a considerable distribution of colorectal cancers (CRCs), of which only about 5% occurs through well-established hereditary syndromes. It has been demonstrated that deleterious variants at the newly identified cancer-predisposing genes could describe the etiology of undefined familial cancers.MethodsThe present study aimed to identify the genetic etiology in a 32-year-old man with early onset familial CRC employing several molecular diagnostic techniques. DNA was extracted from tumoral and normal formalin-fixed-paraffin-embedded (FFPE) blocks, and microsatellite instability (MSI) was evaluated. Immunohistochemistry staining of MMR proteins was performed on tumoral FFPE blocks. Next-generation sequencing (NGS), multiplex ligation-dependent amplification (MLPA) assay, and Sanger sequencing were applied on the genomic DNA extracted from peripheral blood. Data analysis was performed using bioinformatics tools. Genetic variants interpretation was based on ACMG.ResultsMSI analysis indicated MSI-H phenotype, and IHC staining proved no expressions of MSH2 and MSH6 proteins. MLPA and NGS data showed no pathogenic variants in MMR genes. Further analysis of NGS data revealed a candidate WRN frameshift variant (p.R389Efs*3), which was validated with Sanger sequencing. The variant was interpreted as pathogenic since it met the criteria based on the ACMG guideline including very strong (PVS1), strong (PS3), and moderate (PM2).ConclusionWRN is a DNA helicase participating in DNA repair pathways to sustain genomic stability. WRN deficient function may contribute to CRC development that is valuable for further investigation as a candidate gene in hereditary cancer syndrome diagnosis.
A Retrospective Review Following the Addition of Clonidine to a Neonatal Abstinence Syndrome Treatment Algorithm
Authors: Bader Mohammad Y. , Zaghloul Nahla , Repholz Ashley , Nagy Nadia , Ahmed Mohamed N. , Thompson Leslie , Kylat Ranjit I. 
Published: June 2021

Objective: To investigate the outcomes associated with the implementation of a neonatal abstinence syndrome (NAS) treatment algorithm utilizing dual therapy with morphine sulfate and clonidine in a level four neonatal intensive care unit (NICU).Study Design: A cohort of neonates (≥35 weeks gestation) born at an academic tertiary medical center between January 1, 2015 and December 31, 2018 who were diagnosed with NAS were retrospectively evaluated following the implementation of a new NAS treatment algorithm. Neonates were categorized in two groups based on if they were treated pre- or post-implementation of the protocol. The primary efficacy outcome was length of hospital stay. Secondary outcomes included the incidence of adverse drug reactions, length of treatment for NAS, and maximum as well as total cumulative dose of each medication used to treat NAS.Results: The implementation of this NAS treatment algorithm significantly reduced the length of hospital stay (30 days vs. 20 days, p = 0.001). In addition, there was a significant decrease in duration of morphine sulfate exposure as well as cumulative dose of morphine required to successfully treat a neonate with NAS in the post-implementation group (26 days vs. 15 days, p = 0.002 and 6.9 mg/kg vs. 3.4 mg/kg, p = 0.031).Conclusion: Addition of clonidine to morphine sulfate as initial therapy for NAS significantly reduced the cumulative exposure as well as duration of exposure to morphine sulfate compared to morphine monotherapy and decrease length of hospital stay.