bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 629: IFN-Gamma-Dependent Repression of TET2 in Allograft Vasculopathy Exacerbates VSMC Activation
Authors: Ostriker Allison , Martin Kathleen 
Published: July 2021

Coronary allograft vasculopathy (CAV) occurs in 50% of heart transplant recipients at 10 years after surgery. Allograft failure secondary to CAV accounts for 30% of deaths in heart transplant recipients. CAV is characterized by concentric intimal hyperplasia (IH) in the graft vasculature that causes ischemic injury to the myocardium. T cell-derived INF-γ is a well-established driver of IH in CAV. The molecular mechanisms of IFN-γ-dependent phenotypic modulation of vascular smooth muscle cells (VSMCs) in CAV are not fully elucidated.
Our group recently showed that TET methylcytosine dioxygenase 2 (TET2) is a master regulator of VSMC phenotype. We hypothesized that IFN-γ modulates TET2 expression and/or function in VSMCs in CAV. We found, using a minor histocompatibility mismatch aorta graft model of allograft vasculopathy, that TET2 expression was decreased in the graft neointima relative to aortic VSMCs prior to grafting. Lineage tracing studies showed that TET2 activity was decreased in donor VSMC-derived cells present in the neointima. Nuclear localization of phospho-STAT1 correlated with TET2 repression in these cells suggesting that IFN-γ signaling may mediate repression of TET2. Further, we found that IFN-y was sufficient to repress TET2 expression in human and mouse VSMCs in vitro. TET2 repression by IFN-γ was not repressed by rapamycin, an mTOR inhibitor known to be effective against CAV but which has significant side effects.
We hypothesized that IFN-γ signaling directly represses TET2. IFN-γ rapidly induced activation of STAT1 in VSMCs in vitro. Transcription factor binding site prediction suggested potential STAT1 binding sites on the TET2 promoter in both human and mouse. ChIP-PCR confirmed that STAT1 occupancy occurs at the TET2 promoter in response to IFN-γ.
Studies are ongoing to determine if STAT1 directly negatively regulates TET2 transcription in response to IFN-γ, and if TET2 overexpression can rescue the effect of IFN-γ on VSMC activation and IH in in vivo models of allograft vasculopathy. Since IFN-y-dependent repression of TET2 is not reversed by rapamycin, elucidating this pathway represents an opportunity for developing complementary therapies to mTOR inhibition that may result in improved outcomes and fewer side effects.
Abstract P099: Soy Food, Bean, Total Legume Consumption and Blood Pressure: The INTERMAP Study
Authors: Oude Griep Linda M , Stamler Jeremiah , Chan Queenie , van Horn Linda , Steffen Lyn M , Miura Katsuyuki , Ueshima Hirotsugu , Okuda Nagako , Zhao Liancheng , Daviglus Martha L , Elliott Paul ,   for the INTERMAP Rsch Group
Published: July 2021

Background:
Legumes, including soy foods and beans, are nutrient-dense high-quality sources of vegetable protein. Evidence from prospective cohort studies suggests beneficial associations between legume consumption and cardiovascular diseases, however, little is known about their impact on blood pressure (BP). Our objective was to quantify associations with BP of consumption of soy food, beans, and total legume consumption, each considered separately.

Methods:
We used cross-sectional data from the International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP) on 4,680 men and women ages 40-59 years from Japan, China, United Kingdom, and United States. During four visits, eight BP and four 24-hr dietary recalls were collected. Regression coefficients per 2SD higher soy food, bean, and total legume intake were estimated using multivariable linear regression models. To estimate overall association, country-specific regression coefficients were pooled, weighted by inverse of their variance. Adjustments were for age, gender, sample, intake of total energy and alcohol, 24-hr urinary sodium excretion, smoking, education, dietary supplement use, adherence to any special diet, history of cardiovascular diseases or diabetes, family history of hypertension, use of antihypertensive, cardiovascular, or diabetes medication, body mass index, and intake of low-fat dairy, vegetables, fibre-rich grain products, red and processed meats, fish and shellfish, and mutually for soy foods or beans.

Results:
Average daily legume intakes (g/1000 kcal) were 69 in Asian participants and 19 in Western participants. Soy foods contributed 91% of total legume intake in Asian participants; beans were the main source of legumes (68%) in Western countries.

In Asian participants, high correlation coefficients were found between intake of soy foods and iron (r=0.34), arginine (r=0.34), aspartic acid (r=0.34), phenylalanine (r=0.32), isoleucine (r=0.30), and magnesium (r=0.30). In Western participants, soy foods were related to dietary magnesium (r=0.30) and beans were highly correlated with dietary fiber (r=0.44) and magnesium (r=0.22).
Total legume intake higher by 76 g/1000 kcal (2SD) was associated with a diastolic BP difference of -0.75 mm Hg (P=0.009) in the total population, -0.70 mm Hg (P=0.05) in Asian, and -0.86 mm Hg (P=0.08) in Western participants. In the total population, diastolic BP differences were -0.62 mm Hg for soy foods (P=0.04) and -0.42 mm Hg for beans and peas (P=0.06). With regard to systolic BP, a significant inverse association was found for soy food intake higher by 41 g/1000 kcal in Western participants (-1.78 mm Hg, P=0.05).

Conclusion:
Higher intake of legumes, especially soy foods, was associated with lower BP levels.
Rationality in Economics and Politics: A Case Study in the Importance of Adequate Conceptual Analysis
Authors: Harder Peter 
Published: July 2021

Abstract
One of the challenges for Cognitive Linguistics in charting the role of conceptualizations in the human world is how to address the frontier between social and cognitive dimensions of those processes that depend on conceptualization. The case that forms the topic of this paper is the conceptualization of rationality, including specifically rational decision-making in relation to economic dilemmas. I am going to take up the concept of rationality with a view to highlighting the connections between on the one hand its complex conceptual structure and on the other hand its complex societal role, focusing on a crucial context, that of determining and implementing economic policy.
Motivation Toward Choosing Psychology as a Secondary School Subject: A Cross-Cultural Comparison
Authors: Sokolová Lenka 
Published: July 2021

Background: During the past two decades, psychology has become a favorite school subject in many countries. This situation has led to studies on students’ attitudes and perceptions of psychology as a secondary school subject. Objective: The purpose of this study was to compare motives for choosing psychology as a school subject among secondary school students (15–19 years of age) from England and Slovakia. Method: In this study, we administered an online questionnaire to gather data about motivation toward studying psychology among secondary students in England ( n = 150) and Slovakia ( n = 210). Results: For both groups, the most frequent motives and beliefs influencing the choice of psychology were self-understanding and understanding behaviors of others. However, significant cross-cultural differences in other motives emerged (e.g., the perception of difficulty of psychology as a school subject). Conclusion: Students, regardless the cultural context, choose psychology mostly to understand how the human mind works and to understand human behavior to help people. Teaching Implications: Pre-tertiary psychology teachers therefore need to accept a challenge to fulfill students’ expectations and to raise awareness of pre-tertiary students’ perceptions and beliefs about psychology among decision makers on national and international levels.
Average mean arterial pressure in the first 6 hours of extracorporeal cardiopulmonary resuscitation in the prediction of the prognosis of neurological outcome: a single-center retrospective study
Authors: Sun Feng , Mei Yong , Lv Jinru , Li Wei , Hu Deliang , Zhang Gang , Zhang Huazhong , Zhang Jinsong , Chen Xufeng 
Published: July 2021

Objective: To study the correlation between the mean arterial pressure (MAP) level in the first 6 hours of extracorporeal cardiopulmonary resuscitation (ECPR) and patients’ neurological outcomes. Methods: Sex, age, basic comorbidities, the time from the first cardiac arrest to the start of CPR, the time from the first cardiac arrest to extracorporeal membrane oxygenation (ECMO), standardized ECMO flow, and the pH value at the beginning of ECMO and after 6 hours were recorded. MAP was recorded every 2 hours during the first 6 hours, and the average was calculated. The lactic acid clearance rate of the first 6 hours was calculated. Evaluated the neurological prognosis of patients at discharge. Then the patients were divided into groups according to their average MAP, and the above variables were compared in groups. Results: Enrolled 63 adult ECPR patients. There were no statistically significant differences in sex, age, basic comorbidities, the time from the first cardiac arrest to the start of conventional CPR, the time from the first cardiac arrest to the start of ECMO, standardized ECMO flow, 6-hour lactic acid clearance rate, pH value at the sixth hour of operation between two groups. The pH value at the start of ECMO, survival rate, and good prognosis rate in low average MAP group were significantly lower. Low average MAP was associated with poor neurological outcomes (relative risk (RR) 1.50, 95% CI 1.17, 1.92). The RR of good neurological outcome for patients with average MAP ⩾65 mmHg was 5.91 (95% CI 1.45, 24.06), and the RR for average MAP ⩾100 mmHg was 1.18 (95% CI 0.19, 7.52). Conclusion: For ECPR patients, average MAP <65 mmHg in the first 6 hours of ECPR indicates a poor neurological prognosis. However, whether higher average MAP levels can improve the neurological prognosis of ECPR patient remains to be further studied.
The Political Economy of Heteronormativity
Authors: Nguyen Duc Hien 
Published: July 2021

This paper investigates the relationship between heteronormativity, queerness, and neoliberal capitalism. By reinterpreting the 1997 Recognition-Redistribution debate between Nancy Fraser and Judith Butler through a social reproduction lens, I show that Butler’s position is broadly consistent with a social reproduction analysis of heteronormativity. Through stabilizing the gender division of labor, promoting the normative heterosexual family, and contributing to the internal stratification within the working class, heteronormativity fulfills critical social-reproductive roles. Queer emancipation, therefore, cannot be realized without an overhaul of the political economic structure. As relations of reproduction change under neoliberal capitalism, what is constituted as queer is also altered in ways that incorporate queerness into capitalist value production. Mainstream narratives of LGBT progress obscure the emerging division between queers with capital and queers without, a division undergirded by familiar contradictions of racialized, heteronormative, reproductive capitalism. JEL Classification: B51, B54, P16
Patient Pain and Function After Correction of Posterior Malleolar Malunion
Authors: Li Yaxing , Chen Yu , Liu Xi , Chen Jun , Gan Tingjiang , Zhang Hui 
Published: July 2021

Background: The management of an ankle malunion involving the posterior malleolus remains challenging, and only a few published studies described the operative treatment of complex posterior malleolar malunion. A transfibular approach allows for direct visualization of the articular reduction of the posterior malleolus, but the reports of its use for correcting posterior malleolar malunion are rare. This study aims to evaluate the results of the intra-articular osteotomy via a transfibular approach for correcting an ankle malunion involving the posterior malleolus. Methods: We conducted a retrospective review of 26 patients with a symptomatic malunited ankle fracture involving posterior malleolus were treated with the intra-articular osteotomy via a transfibular approach in our department. Radiographic assessments were performed using plain radiographs and computed tomographic (CT) scans. Clinical outcomes were assessed using the AOFAS ankle-hindfoot score, visual analog scale (VAS), active range of motion of ankle, and the 36-Item Short-Form Health Survey score. Results: Postoperatively, anatomic correction of articular surface and anatomic reduction of syndesmosis were achieved in all patients as judged by CT scans. No evidence of progression had been found in 18 of 26 patients (69.2%) at final follow-up. The median AOFAS score improved from 42.0 to 81.5 ( P < .001). Median pain VAS score decreased from 6.0 to 1.0 ( P < .001). A favorable clinical outcome was associated with a short time interval from original injury to correction surgery and a lower grade of preoperative arthritis, but not with the posterior malleolar fragment size. However, time interval, the posterior malleolar fragment size, and the grade of preoperative arthritis showed no correlation with the progression of arthritis grade after surgery. Conclusion: An intra-articular osteotomy via a transfibular approach demonstrated an improved function and pain after operative treatment of malunited ankle fracture with a displaced posterior malleolar fragment. Level of Evidence: Level IV, retrospective case series.
Pars-plana vitrectomy combined with retinectomy in severe open-globe injuries: A systematic review and meta-analysis
Authors: Victor Andi Arus , Violetta Laurencia , Kusumowidagdo Gladys , Pranata Raymond 
Published: July 2021

Background: This review summarized prophylactic retinectomy technique and its effect on anatomic and functional outcomes in severe open globe injuries (OGIs). Methods: A comprehensive search in PubMed (MEDLINE), Embase, Scopus, and EuropePMC databases was performed up until 8 January 2020. Enrolled studies include case series, studies involving pars plana vitrectomy (PPV) combined with retinectomy in severe penetrating injuries with or without IOFB, perforating injuries, and globe ruptures. Primary outcome was best-corrected visual acuity (BCVA) ⩾20/200 at the end of the study. Secondary outcomes were the rate of proliferative retinopathy (PVR), globe survival rate and retinal reattachment rate. Results: A total of seven studies, involving 275 eyes with severe OGIs, is included in this study. Meta-analysis indicates that final BCVA ⩾20/200 was achieved in 61% (95% CI 49%–73%). Meta-regression analysis showed that improvement was inversely affected by the presence of pre-operative direct macular injury ( p = 0.001) and corneal scar ( p = 0.015). The proportion of pre-operative BCVA <20/200 was statistically insignificant to the final BCVA ⩾20/200 ( p = 0.569). One study showed that the rate is higher in the retinectomy group than the non-retinectomy group (54% vs 11%). Meta-analysis showed that anatomical success can be achieved in 85% (95% CI 78%–91%) of the patients. Meta-regression analysis indicates that the anatomical success did not vary with age ( p = 0.653), retinal detachment ( p = 0.525), corneal scar ( p = 0.596), and lens involvement ( p = 0.450). Conclusion: Early PPV combined with retinectomy was associated with acceptable visual improvement and anatomical success.
Cracking behavior and energy consumption of Steel Fiber Concrete Encased Steel beams
Authors: Xu Chao , Wu Kai , Cao Ping zhou , Lin Shi-qi , Chen Zhuo 
Published: July 2021

Steel Fiber Concrete Encased Steel (SFCES) beams were subjected to bending to investigate the effect of steel fibers on the behavior of Steel Reinforced Concrete beams with or without steel reinforcement. 18 SFCES beams reinforced with steel fibers, steel reinforcement, or both were cast. The parameters considered in the experiment were (a) the volume percentage of steel fiber (0%, 1%, and 2%), (b) the shear span to depth ratio( s/d = 2.5 and 3.5), (c) the stirrups spacing (180 mm and 360 mm), and (d) the presence or absence of longitudinal reinforcement (2Φ8+2Φ10).The cracking load, crack development, energy dissipation capacity, and ductility of the specimens were investigated. The results illustrate that the cracking load F c, the total energy consumption, and the energy ductility increase with increasing steel fiber volume, and the average improvement with a steel fiber volume increase of 1% can reach 36.5%, 21.2%, and 28.67%, respectively. However, this strengthening effect of steel fibers was weakened due to the addition of steel reinforcement. The influence of the steel fiber volume and reinforcement configuration on each stage of energy consumption was mainly concentrated in the elastic ( E 1) and failure stages ( E 3). Finally, mathematical equations were proposed to predict the cracking load and crack width of the SFCES specimens, which were verified by comparing the predictions with the experiment results.
Iatrogenic injuries of the popliteus tendon during total knee arthroplasty
Authors: Ammar Ameni , Abcha Oussama , Daghfous Mohamed Samir 
Published: July 2021

Introduction: The popliteus tendon is known to play a key role in the stability of the posterolateral corner of the knee. Its role in the stability of the replaced knee remains contentious. Objectives: The aim of this study was to determine the impact of an iatrogenic lesion of the popliteus tendon during total knee arthroplasty surgery on the stability and function of the knee Methods: We searched in the operating report registers, patients with complete iatrogenic injury of the popliteus tendon during total knee arthroplasty on genu-varum. We evaluated postoperative varus, mobility and stability and we calculated their International Knee Society scores Results: Among the 423 reports of total knee arthroplasties consulted in the operating report registers, we found seven patients with a complete iatrogenic injury of the popliteus tendon. All patients had preoperative extension deficit. All operated knees were stiff, tight and small. At postoperative follow-up, all the knees had good stability and function. All the patients were satisfied. Conclusion: we concluded that the isolated section of the popliteus tendon does not seem to modify the static stability of the knee. However, it can cause a decrease in long-term functional scores. More work is needed to increase understanding of the impact of this iatrogenic lesion on long-term function.
About a rare cause of calf pain in an athlete: the popliteal artery entrapment syndrome
Authors: Abcha Oussama , Ammar Ameni , Daghfous Mohamed Samir 
Published: July 2021

Introduction: Subsequent pain after a central ligament injury of the knee is usually attributed to meniscal or osteochondral damage inherent in trauma or secondary to knee instability. It has not been reported that vascular calf pain can be triggered by knee ligament trauma. Methods: We report a rare case of popliteal artery entrapment syndrome (PAES), discovered during a vascular claudication following post-traumatic anterior instability of the knee. The diagnosis was confirmed by CT angiography which showed a PAES, with a pathway in the inter-condylar notch. The patient had a releasing of the trapped vessel by myomectomy, with disappearance of vascular symptoms six months later. Results: Through this case, we wanted to draw the attention of orthopedic surgeons to the fact that the PAES can be asymptomatic. Its symptomatology can be triggered by a traumatic instability of the knee. Its presence represents a risk of lesion of the popliteal artery during arthroscopic ACL reconstruction. Therefore, it is important to think about this disease if a calf pain occurring after a ligament injury of the knee.
Sorption of selected antiparasitics in soils and sediments
Authors: Heinrich Andre Patrick , Zöltzer Timm , Böhm Leonard , Wohde Manuel , Jaddoudi Sara , El Maataoui Yassine , Dahchour Abdelmalek , Düring Rolf-Alexander 
Published: July 2021

Abstract
Background
Veterinary pharmaceuticals can enter the environment when excreted after application and burden terrestrial and aquatic ecosystems. However, knowledge about the basic process of sorption in soils and sediments is limited, complicating regulatory decisions. Therefore, batch equilibrium studies were conducted for the widely used antiparasitics abamectin, doramectin, ivermectin, and moxidectin to add to the assessment of their environmental fate.

Results
We examined 20 soil samples and six sediments from Germany and Morocco. Analysis was based on HPLC-fluorescence detection after derivatization. For soils, this resulted in distribution coefficients KD of 38–642 mL/g for abamectin, doramectin, and ivermectin. Moxidectin displayed KD between 166 and 3123 mL/g. Normalized to soil organic carbon, log KOC coefficients were 3.63, 3.93, 4.12, and 4.74 mL/g, respectively, revealing high affinity to organic matter of soils and sediments. Within sediments, distribution resulted in higher log KOC of 4.03, 4.13, 4.61, and 4.97 mL/g for the four substances. This emphasizes the diverse nature of organic matter in both environmental media. The results also confirm a newly reported log KOW for ivermectin which is higher than longstanding assumptions. Linear sorption models facilitate comparison with other studies and help establish universal distribution coefficients for the environmental risk assessment of veterinary antiparasitics.

Conclusions
Since environmental exposure affects soils and sediments, future sorption studies should aim to include both matrices to review these essential pharmaceuticals and mitigate environmental risks from their use. The addition of soils and sediments from the African continent (Morocco) touches upon possible broader applications of ivermectin for human use. Especially for ivermectin and moxidectin, strong sorption further indicates high hydrophobicity and provides initial concern for potential aquatic or terrestrial ecotoxicological effects such as bioaccumulation. Our derived KOW estimates also urge to re-assess this important regulatory parameter with contemporary techniques for all four substances.

Graphic abstract
Genome-wide profiling of long noncoding RNAs involved in wheat spike development
Authors: Cao Pei , Fan Wenjuan , Li Pengjia , Hu Yuxin 
Published: July 2021

Abstract
Background
Long noncoding RNAs (lncRNAs) have been shown to play important roles in the regulation of plant growth and development. Recent transcriptomic analyses have revealed the gene expression profiling in wheat spike development, however, the possible regulatory roles of lncRNAs in wheat spike morphogenesis remain largely unclear.

Results
Here, we analyzed the genome-wide profiling of lncRNAs during wheat spike development at six stages, and identified a total of 8,889 expressed lncRNAs, among which 2,753 were differentially expressed lncRNAs (DE lncRNAs) at various developmental stages. Three hundred fifteen differentially expressed cis- and trans-regulatory lncRNA-mRNA pairs comprised of 205 lncRNAs and 279 genes were predicted, which were found to be mainly involved in the stress responses, transcriptional and enzymatic regulations. Moreover, the 145 DE lncRNAs were predicted as putative precursors or target mimics of miRNAs. Finally, we identified the important lncRNAs that participate in spike development by potentially targeting stress response genes, TF genes or miRNAs.

Conclusions
This study outlines an overall view of lncRNAs and their possible regulatory networks during wheat spike development, which also provides an alternative resource for genetic manipulation of wheat spike architecture and thus yield.