bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PELAYANAN PRIMA TERHADAP KEPUASAN NASABAH PADA PT. BPR. SURYA KATIALO
Authors: Subagiyo Subagiyo , Indah Zuraedah 
Published: July 2021

Perkembangan dunia perbankan yang dewasa ini bergerak sangat cepat disertai dengan adanya tantangan-tantangan yang semakin luas dan kompleks. Hal tersebut membuat perbankan harus cepat dan tanggap dalam menjalankan fungsi dan tanggung jawabnya melayani masyarakat. Bank adalah salah satu lembaga keuangan yang bergerak dalam bidang pelayanan jasa keuangan, sehingga harus dapat memberikan pelayanan yang terbaik (service excellent) agar dapat memenangkan persaingan yang semakin hari semakin kompetitif.
Selanjutnya dirumuskan permasalahan bagaimana pelaksanaan pelayanan prima, tingkat kepuasan nasabah dan seberapa besar pengaruh pelayanan prima terhadap kepuasan nasabah pada PT. BPR. Surya Katialo. Tujuannya untuk mengetahui bagaimana pelaksanaan pelayanan prima, tingkat kepuasan nasabah dan hubungan pelayanan prima dengan kepuasan nasabah.
Metode penelitian yang digunakan adalah deskriptif analis. Meneliti populasi dan menentukan survei pada objek penelitian perusahaan. Populasi penelitian sebanyak 300 orang dengan pengambilan sampel secara sampling jenuh sehingga jumlah sampel pada penelitian ini berjumlah 30 orang.
Hasil penelitian menunjukan bahwa korelasi antara pelayanan prima dengan kepuasan nasabah dihasilkan r = 0,86 termasuk kategori sangat kuat dan hasil pengujian statistik melalui uji t (pada tingkat kekeliruan 5 % nilai ttabel 2,048) sedangkan hasil analisis diperoleh thitung 8,94 maka dinyatakan bahwa terdapat pengaruh signifikan pelayanan prima terhadap peningkatan kepuasan nasabah. Koefisien determinasi 73,96% sehingga kepuasan nasabah dipengaruhi oleh pelayanan prima sebesar 73,96%. Sedangkan untuk regresi linear dihasilkan persamaan Y=9,98+1,56X yang artinya apabila nilai X dinaikkan 1 satuan maka nilai Y akan naik sebesar 1,56 pada konstanta 9,98.
Kesimpulan dari penelitian ini terdapat pengaruh positif dan signifikan pelayanan prima terhadap kepuasan nasabah pada PT. BPR. Surya Katialo. Saran untuk meningkatkan kepuasan nasabah PT. BPR. Surya Katialo agar meningkatkan pelayanan prima sehingga pada akhirnya peningkatan kepuasan nasabah akan jauh lebih maksimal.
KAJIAN PENGARUH LIMBAH PLASTIK TERHADAP PRILAKU TANAH BERMASALAH DILAPANGAN
Authors: Herman Herman , Widya SR. Widya SR. , Andrea FY. Andrea FY. 
Published: July 2021

Salah satu penangan jenis tanah bermasalah dilapangan untuk dijadikan tanah dasar jalan raya adalah dengan mencampur tanah tersebut dengan tanah lain yang gradasi dan mutunya lebih baik. Pekerjaan ini sudah umum dilakukan, pada penelitian ini penulis mencoba menggunakan bahan limbah plastik sebagai bahan pencampur, untuk mengetahui sejauh mana efektifitas bahan limbah plastik ini dapat memperbaiki sifat-sifat tanah bermasalah tersebut.
Limbah plastik yang digunakan adalah kresek bekas dengan ukuran lolos saringan no. 10, persentase campuran adalah 0%, 1%, 2% dan 3% limbah plastik terhadap berat kering tanah. Pengujian dilakukan adalah uji sifat-sifat fisis dan uji sifat-sifat mekanis tanah, baik tanah asli maupun tanah yang telah dicampur dengan limbah plastik.
Hasil pengujian sifat-sifat fisis tanah menunjukan bahwa semakin meningkat persentase limbah plastik didalam tanah, persentase lolos saringan no.200, batas cair (LL), indeks plastisitas (PI) dan specific gravity (Gs) cenderung menurun, sebaliknya nilai batas plastis (PL), batas susut (SL) meningkat. Sedangkan pada uji sifat-sifat mekanis tanah terlihat seiring meningkatnya kandungan limbah platik dalam tanah, tekanan pengembangan turun dan nilai kuat tekan bebas meningkat. Nilai-nilai kepadatan tanah, CBR Laboratorium (soaken, unsoaked), pengembangan, pada awalnya meningkat yaitu sampai pada 1% limbah plastik didalam kandungan tanah dan dengan bertambahnya persentase limbah plastik selanjutnya, nilai-nilai ini menurun.
PROBLEMATIKA PEMENUHAN HAK MENYAMPAIKAN PENDAPAT DAN PELANGGARAN TERHADAP HAK ATAS KESEHATAN DI INDONESIA
Authors: Marlina Tat , Handoko Duwi 
Published: July 2021

The purpose of this paper is to find out the problem of fulfilling the right to express opinions and violations of the right to health in Indonesia. This type of research is normative legal research specifically discussing human rights in the field of expressing opinions and rights to health. Data analysis in this study was carried out systematically based on the research problems described qualitatively. In relation to expressing opinions in public, such as demonstrations or demonstrations with many participants, restrictions on freedom are usually associated with "public order" or public orders. The most difficult is how to provide a balance between freedom and public order. Demonstrations by a number of doctors certainly have an impact on patient care, which in principle has harmed the public interest. In addition, the demonstration by blocking the road body certainly hurts the public interest, namely the interests of all road users. Based on the results of Komnas HAM's investigation, at least 15 types of human rights violations were affected by Lapindo mudflow victims. The problem when it is associated with the right to health is in the form of: not a few refugees whose health is disrupted resulting in people falling ill and some dying due to the absence of a proper environment for displaced people; and gas contaminated air and clean water facilities that are damaged are not handled properly by the government.
Keywords: human rights, freedom of opinion, right to health
Ocular Tuberculosis: Clinics, Diagnosis and Treatment (Literature Review)
Authors: Russkikh O. E. , Nikolenko N. Y. 
Published: July 2021

Ocular tuberculosis is a serious disease with a long recurrent course, often leading to a significant decrease in the visual functions and quality of life of patients as well as disability. In recent years, the incidence rate of the ocular tuberculosis in the Russian Federation has been declining: in 2016, according to a number of authors, its incidence amounted to 5.2%.Purpose. To systematize literature data on the topic of ocular tuberculosis.Materials and methods. We reviewed literature available on elibrary.ru, cyberleninka.ru websites and in “Clinical Ophthalmology” journal. Results. We suggested classification of the ocular tuberculosis lesions, analyzed modern diagnostic methods and treatment regimens and evaluated their effectiveness.Conclusions. Literature review revealed that in order to improve the quality of detection, diagnosis and treatment of ocular tuberculosis, joint efforts of ophthalmologists and phthisiologists as well as use of modern methods of tuberculinodiagnosis are essential.
Criterios de inelegibilidad al uso de platinos en cáncer otorrinolaringológico, Guías 2021
Authors: Moreno Ocampo Andrea Paola , Torres Toala Fausto Gady , Moncayo Jorge , Riofrío Mauricio , Chusino Eulalia , Loor Gabriela , Peralta Alexandra , Guarnizo Patricia , Mendoza Mariuxi , Arguello Miriam , Irigoyen Paulina 
Published: July 2021

Introducción: el uso de sales de platinos en patologías oncológicas es ampliamente usado, una de las preocupaciones de los profesionales de la salud es la presencia de eventos adversos en este grupo de pacientes que suelen ser vulnerables, por lo que es necesario la generación de consensos para realizar una selección óptima de pacientes candidatos a terapias basadas en platinos
Objetivo: Realizar un consenso de expertos para la inelegibilidad al uso de platinos de acuerdo a varios criterios para realizar un tratamiento óptimo de acuerdo a la selección y categorización de pacientes
Pregunta de salud cubierta por la Guía: ¿Qué pacientes portadores de cáncer de origen otorrinolaringológico no son elegibles para tratamiento con platinos?
Población: La población objetivos son pacientes adultos con cáncer otorrinolaringológico.
Resultados: Se establecieron consensos para la inelegibilidad al uso de platinos sobre los siguientes criterios: Edad >70 años, ECOG >1, Pérdida involuntaria de peso >20%, función auditiva “borderline”: alteraciones Grado I, Alteraciones neurológicas Grado I, Trastornos de la función renal: CrCL <60 ml/min, Alteración hepática ? grado II Child-Pugh B, Comorbilidades: diabetes, HTA, alteraciones pulmonares, anemia e Insuficiencia cardiaca.
ORC6, Negatively Regulated by miR-1-3p, Promotes Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells
Authors: Chen Hu , Bao Lequn , Hu Jianhua , Wu Dongde , Tong Xianli 
Published: July 2021

BackgroundIn recent years, microRNA-1-3p (miR-1-3p) has been linked to the progression of multiple cancers, whereas little is known about its role in hepatocellular carcinoma (HCC). Herein, we investigated the function of miR-1-3p in HCC, and its regulatory function on origin recognition complex subunit 6 (ORC6).MethodsQuantitative real-time polymerase chain reaction (qRT-PCR) was performed for detecting the expression levels of miR-1-3p and ORC6 mRNA in HCC samples and cell lines. ORC6 expression at the protein level was quantified by Western blot. After gain-of-function and loss-of-function models were established, cell counting kit-8 (CCK-8) assays, Transwell assays, flow cytometry, and 5-Ethynyl-2′-deoxyuridine (EdU) assay were performed for examining cell proliferation, migration, invasion, cell cycle, and apoptosis. The targeting relationship between miR-1-3p and ORC6 was confirmed with bioinformatic analysis and dual-luciferase reporter assays.ResultsThe expression of miR-1-3p was reduced in HCC samples and cell lines. Overexpression of miR-1-3p suppressed the proliferation, migration, and invasion, and induced cell-cycle arrest and apoptosis of HCC cells, whereas the opposite effects were induced by miR-1-3p inhibition. ORC6 is identified as a novel target of miR-1-3p, the expression of which is negatively correlated with miR-1-3p expression in HCC tissues. ORC6 overexpression facilitated the proliferation, migration, invasion, and cell cycle progression, and reduced apoptosis of HCC cells, whereas the opposite effects were induced by ORC6 knockdown. What is more, ORC6 overexpression counteracted the biological functions of miR-1-3p in HCC cells.ConclusionMiR-1-3p targets ORC6 to suppress the proliferation, migration, invasion, and cell cycle progression, and promote apoptosis of HCC cells.
Effects of Biochar Feedstock and Pyrolysis Temperature on Soil Organic Matter Mineralization and Microbial Community Structures of Forest Soils
Authors: Lu Xiaorong , Yin Yan , Li Shaopeng , Ma Hongliang , Gao Ren , Yin Yunfeng 
Published: July 2021

Biochar has received much attention as a strategy to enhance soil carbon (C) sequestration and mitigate climate change. Previous studies found that the feedstock and pyrolysis temperature can largely determine biochar properties, which in turn, impact the stability of native soil organic matter (SOM) and soil microorganisms. The Schima superba and Cunninghamia lanceolata are two tree species widely distributed in the subtropical region of southern China, but how the biochars from these two species influence the soil C sequestration and microbial communities of plantation remain poorly understood. In this study, we produced biochars from these two different feedstocks (13C-labeled S. superba and C. lanceolata litters) at three pyrolysis temperatures (350°C, 550°C, 750°C), then added them to the soils from C. lanceolata plantation, and maintained the experiments at 25°C for 112 days. We found both C mineralization and soil microbial community structures were strongly, but inconsistent, affected by biochar feedstock and pyrolysis temperature. The C. lanceolata biochar triggered the negative priming effect faster and greater compared with the S. superba biochar amendment. Biochars produced at 550°C showed the most significant negative priming effect during the whole incubation period, regardless of the different feedstocks. The cumulative amount of CO2 derived from biochars was significantly decreased with pyrolysis temperature (p &lt; 0.05), indicating that biochars prepared at higher temperatures were more stable in the soil. Further, the soil microbial community structure was only affected by biochar pyrolysis temperature rather than biochar feedstock and their interaction. Together, our results reveal that biochar feedstock and pyrolysis temperature may play more important roles in dictating the priming effect than the structure of microbial community for C. lanceolata plantation. Overall, we concluded that the biochars prepared at 550°C could rapidly decrease the turnover of native SOM in a short term and biochar amendment has the potential to be a management practice for soil C sequestration in the C. lanceolata plantation.
Effect of Point Spread Function Deconvolution in Reconstruction of Brain 18F-FDG PET Images on the Diagnostic Thinking Efficacy in Alzheimer's Disease
Authors: Doyen Matthieu , Mairal Elise , Bordonne Manon , Zaragori Timothée , Roch Véronique , Imbert Laetitia , Verger Antoine 
Published: July 2021

Purpose: This study aims to determine the effect of applying Point Spread Function (PSF) deconvolution, which is known to improve contrast and spatial resolution in brain 18F-FDG PET images, to the diagnostic thinking efficacy in Alzheimer's disease (AD).Methods: We compared Hoffman 3-D brain phantom images reconstructed with or without PSF. The effect of PSF deconvolution on AD diagnostic clinical performance was determined from digital brain 18F-FDG PET images of AD (n = 38) and healthy (n = 35) subjects compared to controls (n = 36). Performances were assessed with SPM at the group level (p &lt; 0.001 for the voxel) and at the individual level by visual interpretation of SPM T-maps (p &lt; 0.005 for the voxel) by the consensual analysis of three experienced raters.Results: A mix of large hypometabolic (1,483cm3, mean value of −867 ± 492 Bq/ml) and intense hypermetabolic (902 cm3, mean value of 1,623 ± 1,242 Bq/ml) areas was observed in the PSF compared to the no PSF phantom images. Significant hypometabolic areas were observed in the AD group compared to the controls, for reconstructions with and without PSF (respectively 23.7 and 26.2 cm3), whereas no significant hypometabolic areas were observed when comparing the group of healthy subjects to the control group. At the individual level, no significant differences in diagnostic performances for discriminating AD were observed visually (sensitivity of 89 and 92% for reconstructions with and without PSF respectively, similar specificity of 74%).Conclusion: Diagnostic thinking efficacy performances for diagnosing AD are similar for 18F-FDG PET images reconstructed with or without PSF.
The Interplay Between Prenatal Adversity, Offspring Dopaminergic Genes, and Early Parenting on Toddler Attentional Function
Authors: Szekely Eszter , Jolicoeur-Martineau Alexia , Atkinson Leslie , Levitan Robert D. , Steiner Meir , Lydon John E. , Fleming Alison S. , Kennedy James L. , Wazana Ashley 
Published: July 2021

Background: Few studies have explored the complex gene-by-prenatal environment-by-early postnatal environment interactions that underlie the development of attentional competence. Here, we examined if variation in dopamine-related genes interacts with prenatal adversity to influence toddler attentional competence and whether this influence is buffered by early positive maternal behavior.Methods: From the Maternal Adversity, Vulnerability and Neurodevelopment cohort, 134 participants (197 when imputing missing data) had information on prenatal adversity (prenatal stressful life events, prenatal maternal depressive symptoms, and birth weight), five dopamine-related genes (DAT1, DRD4, DRD2, COMT, BDNF), observed maternal parenting behavior at 6 months and parent-rated toddler attentional competence at 18 and 24 months. The Latent Environmental and Genetic Interaction (LEGIT) approach was used to examine genes-by-prenatal environment-by-postnatal environment interactions while controlling for sociodemographic factors and postnatal depression.Results: Our hypothesis of a three-way interaction between prenatal adversity, dopamine-related genes, and early maternal parenting behavior was not confirmed. However, consistent two-way interactions emerged between prenatal adversity and dopamine-related genes; prenatal adversity and maternal parenting behavior, and dopamine-related genes and maternal parenting behavior in relation to toddler attentional competence. Significant interaction effects were driven by theDAT1, COMT, andBDNFgenotypes; prenatal stressful life events; maternal sensitivity, tactile stimulation, vocalization, and infant-related activities.Conclusions: Multiple dopamine-related genes affected toddler attentional competence and they did so in interaction with prenatal adversity and the early rearing environment, separately. Effects were already visible in young children. Several aspects of early maternal parenting have been identified as potential targets for intervention.
Mechanical Thrombectomy in Isolated Occlusion of the Proximal Posterior Cerebral Artery
Authors: Herweh Christian , Abdalkader Mohamad , Nguyen Thanh N. , Puetz Volker , Schöne Daniela , Kaiser Daniel , Chen Chih-Hao , Jeng Jiann-Shing , Möhlenbruch Markus A. , Ringleb Peter A. , Nagel Simon 
Published: July 2021

Introduction: Endovascular therapy (EVT) is established as first-line treatment for acute ischemic stroke (AIS) due to large vessel occlusion (LVO) in the anterior circulation. For basilar artery occlusion, recent randomized clinical trials demonstrated not only equipoise but also advantages for EVT under particular circumstances. It remains unclear whether EVT offers an advantage over best medical management (BMM) including thrombolysis (IVT) in isolated occlusion of the proximal posterior cerebral artery (PCAO).Methods: Patients with AIS due to PCAO proven by CT or MR angiography were retrospectively identified from local databases at four comprehensive stroke centers in Germany, USA, and Taiwan between 2012 and 2020. Demographic and clinical data were collected, and imaging characteristics including pretherapeutic, interventional, and follow-up imaging were reviewed locally at each center. Patients were grouped according to therapy, i.e., BMM including IVT alone vs. BMM and EVT. Efficacy endpoints were early neurological improvement (ENI) after 24 h or at discharge, good outcome (modified Rankin scale 0–2) after 3 months, as well as hemorrhagic complications and in-house deaths as safety endpoints.Results: We included 130 patients of whom 23 (17.7%) received EVT. EVT patients had more proximal occlusions (69.9 vs. 43%, p = 0.023) and had a better premorbid function [premorbid mRS, 0 (0–4) vs. 1 (0–3), p &lt; 0.01] when compared to BMM patients. IVT showed a trend toward being less performed in the EVT group (21.7 vs. 41.1%, p = 0.1), while other baseline parameters were balanced. Successful reperfusion was achieved in 52% of EVT patients. ENI was more frequent in the EVT group (61 vs. 35.5%, p = 0.034). Good outcome at 90 days and safety endpoints did not differ. In a bivariate analysis, ENI was independently predicted by the use of EVT (OR, 2.76; CI, 1.055–7.04) and the baseline National Institutes of Health Stroke Scale (NIHSS) (OR, 1.082; CI, 1.027–1.141 per point increase).Discussion: EVT in isolated PCAO appears safe and feasible. Positive effects on clinical outcome are primarily on ENI but also depend on the initial stroke severity. Further prospective or randomized studies are needed to better describe the potential long-term clinical benefits of EVT for PCAO as compared with best medical management.
Effects of Daytime Dry Fasting on Hydration, Glucose Metabolism and Circadian Phase: A Prospective Exploratory Cohort Study in Bahá'í Volunteers
Authors: Koppold-Liebscher Daniela A. , Klatte Caroline , Demmrich Sarah , Schwarz Julia , Kandil Farid I. , Steckhan Nico , Ring Raphaela , Kessler Christian S. , Jeitler Michael , Koller Barbara , Ananthasubramaniam Bharath , Eisenmann Clemens , Mähler Anja , Boschmann Michael , Kramer Achim , Michalsen Andreas 
Published: July 2021

Background: Religiously motivated Bahá'í fasting (BF) is a form of intermittent dry fasting celebrated by abstaining from food and drinks during daylight hours every year in March for 19 consecutive days.Aim: To test the safety and effects of BF on hydration, metabolism, and the circadian clock.Methods: Thirty-four healthy Bahá'í volunteers (15 women) participated in this prospective, exploratory cohort study. Laboratory examinations were carried out in four study visits: before fasting (V0), in the third week of fasting (V1) as well as 3 weeks (V3) and 3 months (V4) after fasting. Data collection included blood and urine samples, anthropometric measurements and bioelectrical impedance analysis. At V0 and V1, 24- and 12-hour urine and serum osmolality were measured. At V0–V2, alterations in the circadian clock phase were monitored in 16 participants. Our study was augmented by an additional survey with 144 healthy Bahá'í volunteers filling out questionnaires and with subgroups attending metabolic measurements (n = 11) and qualitative interviews (n = 13), the results of which will be published separately.Results: Exploratory data analysis revealed that serum osmolality (n = 34, p &lt; 0.001) and 24-hour urine osmolality (n = 34, p = 0.003) decreased during daytime fasting but remained largely within the physiological range and returned to pre-fasting levels during night hours. BMI (body mass index), total body fat mass, and resting metabolic rate decreased during fasting (n = 34, p &lt; 0.001), while body cell mass and body water appeared unchanged. The circadian phase estimated by transcript biomarkers of blood monocytes advanced by 1.1 h (n = 16, p &lt; 0.005) during fasting and returned to pre-fasting values 3 weeks after fasting. Most observed changes were not detectable anymore 3 months after fasting.Conclusions: Results indicate that BF (Bahá'í fasting) is safe, has no negative effects on hydration, can improve fat metabolism and can cause transient phase shifts of circadian rhythms.Trial Registration:https://www.clinicaltrials.gov/, identifier: NCT03443739.
A CT-Based Radiomics Nomogram for Preoperative Prediction of Lymph Node Metastasis in Periampullary Carcinomas
Authors: Bi Lei , Liu Yubo , Xu Jingxu , Wang Ximing , Zhang Tong , Li Kaiguo , Duan Mingguang , Huang Chencui , Meng Xiangjiao , Huang Zhaoqin 
Published: July 2021

PurposeTo establish and validate a radiomics nomogram for preoperatively predicting lymph node (LN) metastasis in periampullary carcinomas.Materials and MethodsA total of 122 patients with periampullary carcinoma were assigned into a training set (n = 85) and a validation set (n = 37). The preoperative CT radiomics of all patients were retrospectively assessed and the radiomic features were extracted from portal venous-phase images. The one-way analysis of variance test and the least absolute shrinkage and selection operator regression were used for feature selection. A radiomics signature was constructed with logistic regression algorithm, and the radiomics score was calculated. Multivariate logistic regression model integrating independent risk factors was adopted to develop a radiomics nomogram. The performance of the radiomics nomogram was assessed by its calibration, discrimination, and clinical utility with independent validation.ResultsThe radiomics signature, constructed by seven selected features, was closely related to LN metastasis in the training set (p &lt; 0.001) and validation set (p = 0.017). The radiomics nomogram that incorporated radiomics signature and CT-reported LN status demonstrated favorable calibration and discrimination in the training set [area under the curve (AUC), 0.853] and validation set (AUC, 0.853). The decision curve indicated the clinical utility of our nomogram.ConclusionOur CT-based radiomics nomogram, incorporating radiomics signature and CT-reported LN status, could be an individualized and non-invasive tool for preoperative prediction of LN metastasis in periampullary carcinomas, which might assist clinical decision making.