bluuebunny/crossref_metadata_2025_split huggingface dataset:
P–778 Repeated cryopreservation process impairs embryo implantation potential but does not affect neonatal outcomes
Authors: Wang M , Zhu L , Jin L 
Published: August 2021

Abstract

Study question
Does repeated cryopreservation process effect embryo implantation potential and neonatal outcomes of human embryos?

Summary answer
Repeated cryopreservation impaired embryo implantation potential, resulting in a lower live birth rate and higher miscarriage rate, despite a comparable neonatal complication rate.

What is known already
With significant advances in the field of ART, the number of available embryos for transfer per cycle has also increased, resulting in a slew of surplus embryo cryopreservation. However, limited researches have focused on the embryonic development potential, clinical outcomes, pregnancy complications as well as the neonatal complications of embryos experiencing repeated cryopreservation.

Study design, size, duration
This was a retrospective, single-center cohort study. All ART cycles from January 2014 to December 2018. Age, body mass index, and number of oocytes retrieved were preferentially matched within a required range, with a total of 709 couples included in the study.

Participants/materials, setting, methods
The study was conducted in the Reproductive Medicine Centre affiliated to a university. Preferentially matched participants were divided into three groups according to the times of embryo cryopreservation: the fresh group (n = 249), the cryopreservation group (n = 244) and the re-cryopreservation group (n = 216). Embryo implantation rate, live birth rate, miscarriage rate, and neonatal complication rate were compared among these three groups.

Main results and the role of chance
The embryo implantation rate, clinical pregnancy rate and live birth rate in the re-cryopreservation group were significantly lower, and there was also a slight increase in the miscarriage rate. Logistic regression analysis indicated that embryos with repeated cryopreservation and lower TE scores were at higher risk of embryo implantation failure in single embryo transfer cycles (OR = 1.79 and 1.56 respectively). No significant differences were observed in gender, gestational age, birthweight, neonatal abnormality, and neonatal complications among the groups.

Limitations, reasons for caution
This was a retrospective cohort study conducted in single center. A multi-center prospective study with a larger sample size in well-matched participants is needed to reinforce our findings.
Wider implications of the findings: Our findings demonstrated the adverse effect of repeated cryopreservation on embryo implantation potential. To avoid embryo waste, or in some special circumstances such as re-biopsy in PGT cycles, an additional cryopreservation on embryos was considered to be available to achieve clinical pregnancy and live birth.

Trial registration number
Not applicable
On the Shape Fields Finiteness Principle
Authors: Jiang Fushuai , Luli Garving K , O’Neill Kevin 
Published: August 2021

Abstract
In this paper, we improve the finiteness constant for the finiteness principles for $C^m({\mathbb{R}}^n,{\mathbb{R}}^D)$ and $C^{m-1,1}({\mathbb{R}}^n,{\mathbb{R}}^D)$ selection proven in [ 19] and extend the more general shape fields finiteness principle to the vector-valued case.
A fast, resource efficient, and reliable rule-based system for COVID-19 symptom identification
Authors: Sahoo Himanshu S , Silverman Greg M , Ingraham Nicholas E , Lupei Monica I , Puskarich Michael A , Finzel Raymond L , Sartori John , Zhang Rui , Knoll Benjamin C , Liu Sijia , Liu Hongfang , Melton Genevieve B , Tignanelli Christopher J , Pakhomov Serguei V S 
Published: August 2021

AbstractObjectiveWith COVID-19, there was a need for a rapidly scalable annotation system that facilitated real-time integration with clinical decision support systems (CDS). Current annotation systems suffer from a high-resource utilization and poor scalability limiting real-world integration with CDS. A potential solution to mitigate these issues is to use the rule-based gazetteer developed at our institution.Materials and MethodsPerformance, resource utilization, and runtime of the rule-based gazetteer were compared with five annotation systems: BioMedICUS, cTAKES, MetaMap, CLAMP, and MedTagger.ResultsThis rule-based gazetteer was the fastest, had a low resource footprint, and similar performance for weighted microaverage and macroaverage measures of precision, recall, and f1-score compared to other annotation systems.DiscussionOpportunities to increase its performance include fine-tuning lexical rules for symptom identification. Additionally, it could run on multiple compute nodes for faster runtime.ConclusionThis rule-based gazetteer overcame key technical limitations facilitating real-time symptomatology identification for COVID-19 and integration of unstructured data elements into our CDS. It is ideal for large-scale deployment across a wide variety of healthcare settings for surveillance of acute COVID-19 symptoms for integration into prognostic modeling. Such a system is currently being leveraged for monitoring of postacute sequelae of COVID-19 (PASC) progression in COVID-19 survivors. This study conducted the first in-depth analysis and developed a rule-based gazetteer for COVID-19 symptom extraction with the following key features: low processor and memory utilization, faster runtime, and similar weighted microaverage and macroaverage measures for precision, recall, and f1-score compared to industry-standard annotation systems.
Comparison of beaver density and foraging preferences between urban and rural riparian forests along the South Saskatchewan River, Canada
Authors: England Kirby , Westbrook Cherie J 
Published: August 2021

AbstractBeavers have recolonized much of their historic range throughout the northern hemisphere and numerous studies have documented their habitat preferences and foraging behavior in rural riparian areas. Beavers, however, are also recolonizing waterways in cities, yet there has been little study of habitat use and foraging practices in these managed, urban systems. We studied beaver lodge distribution and riparian foraging preferences along the South Saskatchewan River, Canada, comparing a reach (24 km) passing through the City of Saskatoon where beavers and trees are managed with an upstream reach (29 km) passing through a conservation area where neither beavers nor trees are managed. In a canoe-based census at low flow, we found that beaver density in the conservation area was twice that in the city. Lodges were dispersed in the city with longer water-based distances between them. We found both differences and similarities in beaver foraging behavior. Riparian tree sampling along transects revealed that while diversity in the city and conservation area is markedly different, beavers preferentially cut green ash, Manitoba maple, paper birch and three poplars in both places. Beavers also cut six other tree species in the city, including three that are introduced, but the diversity was higher. A least-squares general linear model showed greater probability of cutting of trees further from the river in the city than conservation area, but of smaller diameter. Study results will be useful to urban planners in managing urban riparian forests and in developing beaver management plans.
A retrospective analysis of bull:cow ratio effects on pregnancy rates of beef cows previously enrolled in fixed-time artificial insemination protocols
Authors: Timlin Claire L , Dias Nicholas W , Hungerford Laura , Redifer Tracey , Currin John F , Mercadante Vitor R G 
Published: August 2021

Abstract
This retrospective study aimed to determine if the number of cows exposed per bull affects pregnancy rates of cows returning to estrus after fixed-time artificial insemination (FTAI). Data were compiled over the course of 13 breeding seasons (six fall and seven spring seasons) between 2010 and 2017 from the Virginia Department of Corrections herd. Available records contained data from 17 farms and 324 groups of cows (average 47 cows/group). Multiparous cows and heifers (average age per group: 5.11 ± 0.14 yr; n = 14,868) were exposed to FTAI. After FTAI, animals were placed on pasture with bulls diagnosed as fertile by a breeding soundness exam for natural service of cows who did not become pregnant to FTAI (n = 7,248; average 22 cows/group). Animals were classified as pregnant to FTAI, to natural service on first return to estrus, or to natural service on second or subsequent estrus determined by fetal aging at pregnancy diagnosis. The bull:cow ratio for the total number of cows exposed ranged from 1:9 to 1:73 with an average of 1:31. The bull:cow ratio considering only open cows exposed after FTAI ranged from 1:2 to 1:44 with an average of 1:14. There was significant negative, small correlation between the bull:cow ratio for total number of cows exposed and return to estrus pregnancy rate in fall breeding seasons (P = 0.01, r2 = 0.04) but not in spring (P = 0.90). There was a significant negative, small correlation between bull:cow ratio of open cows exposed and pregnancy rates to first return to estrus in fall herds with a single sire (P &lt; 0.001, r2 = 0.11). There was no correlation in fall herds using multiple sires or spring herds (P ≥ 0.12). Bull:cow ratio accounted for only 1–11% of variation in the pregnancy rates, thus we conclude that a decreased bull:cow ratio (up to 1:73) did not affect natural service return to estrus pregnancy rate. Cattlemen may consider a reduced number of bulls needed for natural service breeding after FTAI, which can decrease bull related costs and increase the economic feasibility of adopting FTAI protocols.
Motivation and Engagement of Nursing Students in 2 Gamified Courses
Authors: Killam Laura A. , Timmermans Katherine E. , Shapiro Sidney J. 
Published: August 2021

Background
Evidence suggests that gamification increases student engagement in course activities. However, student feedback about gamification in nursing contexts is needed.

Purpose
The aim of this study was to describe nursing student perceptions of how gamification impacts student motivation and engagement.

Methods
A convergent mixed-methods study was conducted. Surveys were completed by 58 first-year nursing students. Survey comments and data extracted from the learning management system were also collected.

Results
Students generally found gamification valuable, interesting, and enjoyable. Gamification took effort and was perceived as important. Students felt that they had some choice in participation in the gamified activities.

Conclusions
Gamification is a viable strategy for promoting motivation and engagement among first year nursing students. More qualitative research is needed to enable game design refinement through investigation of contextualized student experiences. Refined game design may impact the development of learner skills through a moderating effect on engagement in course activities.
Study protocol for the Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): a longitudinal study of the medium and long-term sequelae of SARS-CoV-2 infection
Authors: O’Laughlin Kelli N. , Thompson Matthew , Hota Bala , Gottlieb Michael , Plumb Ian D. , Chang Anna Marie , Wisk Lauren E. , Hall Aron J. , Wang Ralph C. , Spatz Erica S. , Stephens Kari A. , Huebinger Ryan M. , McDonald Samuel A. , Venkatesh Arjun , Gentile Nikki , Slovis Benjamin H. , Hill Mandy , Saydah Sharon , Idris Ahamed H. , Rodriguez Robert , Krumholz Harlan M. , Elmore Joann G. , Weinstein Robert A. , Nichol Graham ,   INSPIRE Investigators
Published: August 2021

ABSTRACTBACKGROUNDReports on medium and long-term sequelae of SARS-CoV-2 infections largely lack quantification of incidence and relative risk. We describe the rationale and methods of the Innovative Support for Patients with SARS-CoV-2 Registry (INSPIRE) that combines patient-reported outcomes with data from digital health records to understand predictors and impacts of SARS-CoV-2 infection.METHODSINSPIRE is a prospective, multicenter, longitudinal study of individuals with symptoms of SARS-CoV-2 infection in eight regions across the US. Adults are eligible for enrollment if they are fluent in English or Spanish, reported symptoms suggestive of acute SARS-CoV-2 infection, and if they are within 42 days of having a SARS-CoV-2 viral test (i.e., nucleic acid amplification test or antigen test), regardless of test results. Recruitment occurs in-person, by phone or email, and through online advertisement. A secure online platform is used to facilitate the collation of consent-related materials, digital health records, and responses to self-administered surveys. Participants are followed for up to 18 months, with patient-reported outcomes collected every three months via survey and linked to concurrent digital health data; follow-up includes no in-person involvement. Our planned enrollment is 4,800 participants, including 2,400 SARS-CoV-2 positive and 2,400 SARS-CoV-2 negative participants (as a concurrent comparison group). These data will allow assessment of longitudinal outcomes from SARS-CoV-2 infection and comparison of the relative risk of outcomes in individuals with and without infection. Patient-reported outcomes include self-reported health function and status, as well as clinical outcomes including health system encounters and new diagnoses.RESULTSParticipating sites obtained institutional review board approval. Enrollment and follow-up are ongoing.CONCLUSIONSThis study will characterize medium and long-term sequelae of SARS-CoV-2 infection among a diverse population, predictors of sequelae, and their relative risk compared to persons with similar symptomatology but without SARS-CoV-2 infection. These data may inform clinical interventions for individuals with sequelae of SARS-CoV-2 infection.
Impact of the World Inflammatory Bowel Disease Day and Crohn’s & Colitis Awareness Week on Population Interest between 2016 and 2020: Google Trends Analysis
Authors: Silangcruz Krixie , Nishimura Yoshito , Czech Torrey , Kimura Nobuhiko , Hagiya Hideharu , Koyama Toshihiro , Otsuka Fumio 
Published: August 2021

AbstractBackgroundMore than 6 million people are affected by inflammatory bowel disease (IBD) globally. World IBD Day (WID; May 19) and Crohn’s and Colitis Awareness Week (CCAW; December 1–7) occur yearly as national health observances to raise public awareness of IBD, but their effects are unclear.MethodsThis study evaluates the impact of WID and CCAW on the public awareness of IBD in the United States (US) and worldwide from 2016 to 2020 using the relative search volume (RSV) of “IBD,” “Ulcerative colitis,” and “Crohn’s disease” in Google Trends (GT). To identify significant timepoints of trend changes (joinpoints), we performed Joinpoint regression analysis.ResultsNo joinpoints were noted around the time of WID or CCAW during the study period in the search results of the US. Worldwide, joinpoints were noted around WID in 2020 with the search for “IBD” and around CAAW in 2017 and 2019 to search for “ulcerative colitis.” However, the extents of trend changes were modest without statistically significant increases.ConclusionsWID and CCAD may not have worked as expected to raise public awareness of IBD. Additional measures are necessary to help raise awareness of IBD related to the health observances.SummaryWorld IBD Day and Crohn’s and Colitis Awareness Week are key health observances related to IBD. These observances, however, might not have been effective in raising public awareness of IBD in the US and worldwide, according to Google Trends analysis.
Building knowledge of university campus population dynamics to enhance near-to-source sewage surveillance for SARS-CoV-2 detection
Authors: Sweetapple Chris , Melville-Shreeve Peter , Chen Albert S. , Grimsley Jasmine M. S. , Bunce Joshua T. , Gaze William , Fielding Sean , Wade Matthew J. 
Published: August 2021

ABSTRACTWastewater surveillance has been widely implemented for monitoring of SARS-CoV-2 during the global COVID-19 pandemic, and near-to-source monitoring is of particular interest for outbreak management in discrete populations. However, variation in population size poses a challenge to the triggering of public health interventions using wastewater SARS-CoV-2 concentrations. This is especially important for near-to-source sites that are subject to significant daily variability in upstream populations. Focusing on a university campus in England, this study investigates methods to account for variation in upstream populations at a site with highly transient footfall and provides a better understanding of the impact of variable populations on the SARS-CoV-2 trends provided by wastewater-based epidemiology. The potential for complementary data to help direct response activities within the near-to-source population is also explored, and potential concerns arising due to the presence of heavily diluted samples during wet weather are addressed. Using wastewater biomarkers, it is demonstrated that population normalisation can reveal significant differences between days where SARS-CoV-2 concentrations are very similar. Confidence in the trends identified is strongest when samples are collected during dry weather periods; however, wet weather samples can still provide valuable information. It is also shown that building-level occupancy estimates based on complementary data aid identification of potential sources of SARS-CoV-2 and can enable targeted actions to be taken to identify and manage potential sources of pathogen transmission in localised communities.
Mortality and outcomes after decompressive craniectomy in children with severe traumatic brain injury
Authors: Bruns N. , Kamp O. , Lange K. , Lefering R. , Felderhoff-Müser U. , Dudda M. , Dohna-Schwake C. ,   TraumaRegister DGU
Published: August 2021

AbstractPurposeThe effect of decompressive craniectomy (DC) on mortality and outcomes in children with elevated intracranial pressure after severe head trauma is strongly debated and high-quality evidence is lacking. This study was conducted to determine whether DC in children with severe head trauma is associated with a decrease in mortality or poor outcomes at discharge from the intensive care unit.MethodsData on patients < 18 years of age treated in Germany, Austria, and Switzerland during a ten-year period were extracted from TraumaRegister DGU®, forming a retrospective multi-centre cohort study. Descriptive and multivariable analyses were performed to compare mortality and outcomes after decompressive craniectomy and medical management.Results2507 patients were included, of which 402 underwent decompressive craniectomy. Mortality was 20.6 % in children undergoing DC compared to 13.7 % after medical management. Observed and predicted mortality after DC and medical management matched in all subgroups except in children between six and 17 years of age, where mortality after DC was lower than predicted. Poor outcome was observed in 27.6 % of DC patients vs. 16.1 % receiving medical management. Logistic regression revealed slightly negative effects of DC on mortality (odds ratio 1.20, not significant) and outcomes (odds ratio 1.56 (95% confidence interval 1.01-2.40).ConclusionDC did not decrease overall mortality or rates of poor outcome. However, children above six years of age may benefit from DC. High quality prospective studies are urgently needed.
Results dissemination from completed clinical trials conducted at German university medical centers remains delayed and incomplete. The 2014-2017 cohort
Authors: Riedel Nico , Wieschowski Susanne , Bruckner Till , Holst Martin R. , Kahrass Hannes , Nury Edris , Meerpohl Joerg J. , Salholz-Hillel Maia , Strech Daniel 
Published: August 2021

AbstractObjectiveTimely publication of clinical trial results is central for evidence-based medicine. The performance of university medical centers (UMCs) regarding timely results publication informs the local and national decision makers, patients, and the public about the need to improve trial results dissemination.Study Design and SettingFollowing the same search and tracking methods used in our previous study for the years 2009 - 2013, we identified trials led by German UMCs completed between 2014 and 2017 and tracked results dissemination for the identified trials.ResultsWe identified 1,658 trials in the 2014-2017 cohort. Of these trials, 43% published results as either journal publication or summary results within 24 months after completion date, which is an improvement of 3.8% percentage points compared to the previous study. At the UMC level, the 24-month publication rates varied from 14% to 71%. Five years after completion, still 30% of the trials remained unpublished.ConclusionDespite minor improvements compared to the previously investigated cohort, the rate of timely reporting of trials led by German UMCs remains low. German UMCs should take further steps to improve timely reporting rates.
Passive Detection of COVID-19 with Wearable Sensors and Explainable Machine Learning Algorithms
Authors: Gadaleta Matteo , Radin Jennifer M. , Baca-Motes Katie , Ramos Edward , Kheterpal Vik , Topol Eric J. , Steinhubl Steven R. , Quer Giorgio 
Published: August 2021

ABSTRACTIndividual smartwatch or fitness band sensor data in the setting of COVID-19 has shown promise to identify symptomatic and pre-symptomatic infection or the need for hospitalization, correlations between peripheral temperature and self-reported fever, and an association between changes in heart-rate-variability and infection. In our study, a total of 38,911 individuals (61% female, 15% over 65) have been enrolled between March 25, 2020 and April 3, 2021, with 1,118 reported testing positive and 7,032 negative for COVID-19 by nasopharyngeal PCR swab test. We propose an explainable gradient boosting prediction model based on decision trees for the detection of COVID-19 infection that can adapt to the absence of self-reported symptoms and to the available sensor data, and that can explain the importance of each feature and the post-test-behavior for the individuals. We tested it in a cohort of symptomatic individuals who exhibited an AUC of 0.83 [0.81-0.85], or AUC=0.78 [0.75-0.80] when considering only data before the test date, outperforming state-of-the-art algorithm in these conditions. The analysis of all individuals (including asymptomatic and pre-symptomatic) when self-reported symptoms were excluded provided an AUC of 0.78 [0.76-0.79], or AUC of 0.70 [0.69-0.72] when considering only data before the test date. Extending the use of predictive algorithms for detection of COVID-19 infection based only on passively monitored data from any device, we showed that it is possible to scale up this platform and apply the algorithm in other settings where self-reported symptoms can not be collected.
MyPlate, Half-Plate, and No Plate: How Visual Plate-related Dietary Benchmarks Influence Meal Composition
Authors: Wansink Brian , Wansink Audrey 
Published: August 2021

AbstractCan visual plate-related dietary guidance systems – such as the MyPlate guideline or the Half-Plate Rule – help people eat better when dining at home or in restaurants? To help explore this, 104 young adults completed a food diary study after having been randomly assigned to follow either 1) USDA MyPlate guidelines, 2) the Half-Plate Rule, or 3) no guidelines (control condition). Both of the visual dietary guidance systems were considered easy to understand, to follow, and left people with fewer questions about what to eat (all p<.01). Moreover, people who rated a system “easy to follow” indicated they had consumed less (meat (r = .268), but this was uncorrelated with fruit and vegetable intake (r =.092) and carbohydrate intake (r = .069). There are three key conclusions to these and other findings: First, the simplest guidance system may be more effective than no system. Second, even the most perfect dietary guidance system will not change behavior if the foods are not available or it is not followed. Third, guidance systems could over-increase the consumption of any food they specifically mention.