bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective analysis of infection of young sheep with intestinal cestodosis in the plain and mountainous zones of the Republic of Dagestan
Authors: Musaev Z. G. , Kabardiev S. Sh. , Gyulakhmedova N. Kh. 
Published: March 2021

The purpose of the research is analysis of infection with intestinal cestodosis of young sheep in the plain and mountainous zones of the Republic of Dagestan.Materials and methods. For a number of years, on the basis of the Caspian Zonal Scientific Research Veterinary Institute – Branch of the Federal State Budgetary Scientific Institution “Federal Agrarian Scientific Center of the Republic of Dagestan”, of the laboratory for the study of infective diseases of livestock and birds, we carried out studies of sheep fecal specimens from various regions of the Republic of Dagestan and tested various antiparasitic drugs.Results and discussion. It has been established that sheep cestodosis are ubiquitous in the Republic, although there are effective antiparasitic drugs, including those of domestic production. The infection extensity by Moniezia sp. in 2015 was 67.8%, Thysaniezia sp. – 12.5%, and Avitellina sp. – 6.2%. In 2016, infections continued to be recorded at a high level. In 2017, monieziosis of lambs was recorded with the infection extensity of 24.0–30.0% and with the infection intensity value of 1.5–6.4 sp. per animal. Avitellinosis was noted in 17.0–23.6 % of sheep with an infection intensity value of 1.0–4.8 sp. per animal. Cestodosis in sheep in 2019 are also found, but less frequently.
Dynamics of intestinal parasite infections in domestic dogs in the city of Perm
Authors: Sivkova T. N. , Chetanov N. A. 
Published: March 2021

The purpose of the research is comparative analysis of the dynamics of intestinal helminth and protozoa infections in domestic dogs in Perm, and establishment of a relationship between the prevalence of infection with certain pathogens.Materials and methods. Samples of feces from domestic dogs from Perm were material for the study. Feces were examined by the combined Kotelnikov-Khrenov method and method of successive washing. The results were processed statistically using the Statistica 10.0 software.Results and discussion. The prevalence of infection with parasites over a 15-year period ranged from 15.38% in 2006 to 44.30% in 2008, and 26.54% in average. The leading position is occupied by Sarcocystis spp. (Lankester, 1882) – 5.92%, Toxocara canis (Werner, 1782) – 5.50% and Isospora canis (Nemesri, 1960) – 2.6%, while the rest of the parasites account for an insignificant amount of identified cases. Statistical analysis of the ten most common parasites among dogs in Perm by years showed a direct relationship between the lungworm Oslerus osleri (sin Filaroides osleri, Cobbold, 1876) and the heteroxenous Coccidia Sarcocystis spp. (rs = 0.572; P < 0.05), as well as a negative correlation between Cryptosporidium spp. (Tyzzer, 1907) and Isospora ohioensis (Dubey, 1975) (rs = -0.526; P < 0.05). When studying Toxocara infection in dogs in different seasons of the year, an increase in the infection prevalence was noted in February with a minimum in July-August. For isosporosis, we identified the spring (March) and more pronounced autumn (September) peaks in infection. Sarcocystosis reached minimum levels of the infection prevalence in September with peaks in May-July. Any correlation between the degree of T. canis, Sarcocystis spp. and I. canis infection in domestic dogs has not been found, which indicates an independent circulation of these pathogens in the urban environment, which does not allow for long-term forecasts of levels of infection, and this must be taken into account when organizing the work of veterinary service.
Efficacy of solid dispersion of fenbendazole against gastrointestinal strongylatosis of young cattle
Authors: Varlamova A. I. , Arkhipov I. A. , Sadov K. M. , Khalikov S. S. , Arisov M. V. , Borzunov E. N. 
Published: March 2021

The purpose of the research is to study the efficacy of solid dispersion of fenbendazole (SDF) against nematodoses of young cattle.Materials and methods. The study of SDF, obtained by mechanochemical processing of fenbendazole substance with polyvinylpyrrolidone (PVP) polymer, was carried out on 126 young cattle naturally infected with nematodiroses and other gastrointestinal strongylatoses. The animals were divided into 6 experimental groups of 10–11 animals each and SDF was administered once orally at doses of 2.0; 3.0 and 4.0 mg/kg of active substance (a.s.) (I-III groups) in comparison with the mechanical mixture of fenbendazole (FBZ) and PVP in a ratio of 1:9 (IV group) and substance FBZ at a dose of 3.0 mg/kg (group V) against each helminthosis. The control group of animals did not receive the drugs. Anthelmintic efficacy was evaluated in the "control test" based on the data of ovoscopic examination of feces of young cattle by flotation method before and 17 days after drugs administration.Results and discussion. SDF with PVP at a dose of 2.0; 3.0 and 4.0 mg/kg of a.s. in the form of a 10% powder showed respectively 88.4; 97.3 and 100% efficiency at nematodiroses and 89.2; 98.4 and 99.5 % activity against other types of gastrointestinal strongylates upon obtaining 32.3 and 32.4 % effect of the mechanical mixture of FBZ with PVP and 29.7 and 27.4% efficiency of the base preparation at a dose of 3.0 mg/kg. SDF showed 88.4; 97.3 and 100% of efficacy at doses of 2.0; 3.0 and 4.0 mg/kg of a.s., respectively, against nematodiroses and 89.2; 98.4 and 99.5% against other gastrointestinal strongylatoses in the form of 10% powder. It should be noted that mechanical mixture of PBZ with PVP showed 32.3 and 32.4% efficacy and the efficacy of the basic drug was 29.7 and 27.4% at a dose of 3.0 mg/kg against each helminthosis.
ЦЕННОСТИ И СМЫСЛЫ НЕНАСИЛИЯ В ПОЛИТИЧЕСКОМ ПРОТЕСТЕ
Authors: Логунова Л. Ю. , Маженина Е. А. 
Published: March 2021

The article presents the results of a long-term study of protest as a cultural phenomenon, the transformation of values, realized in the activities of the best people of the planet and their followers. These values have absorbed the experience of many generations and the behavior of people defending the rights of an individual to dignity, equality before the law, fair attitude, freedom of thought. In the history of the development of political thought, values have formed that constitute the core of civil culture. The genesis of the birth of the nucleus of civil culture from the thinkers of Antiquity, ideologists of nonviolent resistance, leaders of the French bourgeois revolution, activists of the “new left” movement to the protests of our time is shown. The basis for updating the protection of these values is the socio-political situation, characterized by the divergence of interests of civil society and ruling political groups. The values of the core of civil culture (freedom of speech, freedom of conscience, freedom of assembly, human rights) acquire an acute urgency in situations of power crisis. This is the time of the birth of new values that will mobilize new generations of protesters. Protest, as an act of protecting the values of the individual, is a measure of the level of development of political culture in the state. The protest — it's not just a mass exit of dissent on the area. This is an indicator of the level of self-awareness of citizens and the development of the political culture of society. The symbols of political protest actions are a special text that expresses the meanings of values. The authors present the results of a sociological study, which used comparative, value-semantic, interpretive approaches, studied the meanings and values of political protests of the 20th — early 19th centuries, analyzed visual and publicistic evidence of protest actions: photo and video materials, publications in the press.
Endoscopic endonasal versus transcranial surgery for primary resection of craniopharyngiomas based on a new QST classification system: a comparative series of 315 patients
Authors: Fan Jun , Liu Yi , Pan Jun , Peng Yuping , Peng Junxiang , Bao Yun , Nie Jing , Wang Chaohu , Qiu Binghui , Qi Songtao 
Published: March 2021

OBJECTIVE
An assessment of the transcranial approach (TCA) and the endoscopic endonasal approach (EEA) for craniopharyngiomas (CPs) according to tumor types has not been reported. The aim of this study was to evaluate both surgical approaches for different types of CPs.

METHODS
A retrospective review of primary resected CPs was performed. A QST classification system based on tumor origin was used to classify tumors into 3 types as follows: infrasellar/subdiaphragmatic CPs (Q-CPs), subarachnoidal CPs (S-CPs), and pars tuberalis CPs (T-CPs). Within each tumor type, patients were further arranged into two groups: those treated via the TCA and those treated via the EEA. Patient and tumor characteristics, surgical outcomes, and postoperative complications were obtained. All variables were statistically analyzed between surgical groups for each tumor type.

RESULTS
A total of 315 patients were included in this series, of whom 87 were identified with Q-CPs (49 treated via TCA and 38 via EEA); 56 with S-CPs (36 treated via TCA and 20 via EEA); and 172 with T-CPs (105 treated via TCA and 67 via EEA). Patient and tumor characteristics were equivalent between both surgical groups in each tumor type. The overall gross-total resection rate (90.5% TCA vs 91.2% EEA, p = 0.85) and recurrence rate (8.9% TCA vs 6.4% EEA, p = 0.35) were similar between surgical groups. The EEA group had a greater chance of visual improvement (61.6% vs 35.8%, p = 0.01) and a decreased risk of visual deterioration (1.6% vs 11.0%, p < 0.001). Of the patients with T-CPs, postoperative hypothalamic status was better in the TCA group than in the EEA group (p = 0.016). Postoperative CSF leaks and nasal complication rates occurred more frequently in the EEA group (12.0% vs 0.5%, and 9.6% vs 0.5%; both p < 0.001). For Q-CPs, EEA was associated with an increased gross-total resection rate (97.4% vs 85.7%, p = 0.017), decreased recurrence rate (2.6% vs 12.2%, p = 0.001), and lower new hypopituitarism rate (28.9% vs 57.1%, p = 0.008). The recurrence-free survival in patients with Q-CPs was also significantly different between surgical groups (log-rank test, p = 0.037). The EEA required longer surgical time for T-CPs (p = 0.01).

CONCLUSIONS
CPs could be effectively treated by radical surgery with favorable results. Both TCA and EEA have their advantages and limitations when used to manage different types of tumors. Individualized surgical strategies based on tumor growth patterns are mandatory to achieve optimal outcomes.
A propensity-adjusted comparison of middle meningeal artery embolization versus conventional therapy for chronic subdural hematomas
Authors: Catapano Joshua S. , Ducruet Andrew F. , Nguyen Candice L. , Cole Tyler S. , Baranoski Jacob F. , Majmundar Neil , Wilkinson D. Andrew , Fredrickson Vance L. , Cavalcanti Daniel D. , Lawton Michael T. , Albuquerque Felipe C. 
Published: March 2021

OBJECTIVEMiddle meningeal artery (MMA) embolization is a promising treatment strategy for chronic subdural hematomas (cSDHs). However, studies comparing MMA embolization and conventional therapy (surgical intervention and conservative management) are limited. The authors aimed to compare MMA embolization versus conventional therapy for cSDHs using a propensity-adjusted analysis.METHODSA retrospective study of all patients with cSDH who presented to a large tertiary center over a 2-year period was performed. MMA embolization was compared with surgical intervention and conservative management. Neurological outcome was assessed using the modified Rankin Scale (mRS). A propensity-adjusted analysis compared MMA embolization versus surgery and conservative management for all individual cSDHs. Primary outcomes included change in hematoma diameter, treatment failure, and complete resolution at last follow-up.RESULTSA total of 231 patients with cSDH met the inclusion criteria. Of these, 35 (15%) were treated using MMA embolization, and 196 (85%) were treated with conventional treatment. On the latest follow-up, there were no statistically significant differences between groups in the percentage of patients with worsening mRS scores. Of the 323 total cSDHs found in 231 patients, 41 (13%) were treated with MMA embolization, 159 (49%) were treated conservatively, and 123 (38%) were treated with surgical evacuation. After propensity adjustment, both surgery (OR 12, 95% CI 1.5–90; p = 0.02) and conservative therapy (OR 13, 95% CI 1.7–99; p = 0.01) were predictors of treatment failure and incomplete resolution on follow-up imaging (OR 6.1, 95% CI 2.8–13; p < 0.001 and OR 5.4, 95% CI 2.5–12; p < 0.001, respectively) when compared with MMA embolization. Additionally, MMA embolization was associated with a significant decrease in cSDH diameter on follow-up relative to conservative management (mean −8.3 mm, 95% CI −10.4 to −6.3 mm, p < 0.001).CONCLUSIONSThis propensity-adjusted analysis suggests that MMA embolization for cSDH is associated with a greater extent of hematoma volume reduction with fewer treatment failures than conventional therapy.
Endoscope-assisted microsurgical repair in trigeminal meningocele: case report
Authors: Yasuda Takaya , Kurosaki Yoshitaka , Ishibashi Ryota , Takada Kensuke , Chin Masaki 
Published: March 2021

Trigeminal meningocele is a rare disease that results in rhinorrhea. Treatments with endoscopic approaches and open craniotomies have high recurrence rates, and controversy regarding the most effective surgical strategy for trigeminal meningocele is ongoing.
The authors report a case of a 13-year-old female patient with a diagnosis of trigeminal meningocele determined after she presented with a history of intermittent headaches, suspected rhinorrhea, and recurrent meningitis. In addition to the conventional method of covering the efflux point of CSF and filling the inside of the meningocele with fascial tissues, the authors selectively closed the influx point of CSF from the prepontine cistern to the meningocele using an anterior transpetrosal approach. On the basis of the preoperative images, the authors hypothesized that the influx point of CSF could not be observed under the microscopic direct view and instead used a flexible endoscope. A check valve–like structure with one-way communication of CSF from the prepontine cistern into the cystic cavity was identified and was closed.
At the time of this report, 36 months postoperatively, the patient had no indications of recurrence. Although cases of trigeminal meningoceles are infrequently encountered and require a tailored approach, the results in this case thus far indicate that the use of an endoscope and open craniotomy is an effective strategy for surgical treatment.
Postoperative facial palsy after pediatric posterior fossa tumor resection
Authors: Chu Jason K. , Chiarelli Peter A. , Rea Nolan D. , Pimentel Norianne , Flyer Benjamin E. , McComb J. Gordon , Durham Susan R. , Krieger Mark D. 
Published: March 2021

OBJECTIVE
Facial palsy can be caused by masses within the posterior fossa and is a known risk of surgery for tumor resection. Although well documented in the adult literature, postoperative facial weakness after posterior fossa tumor resection in pediatric patients has not been well studied. The objective of this work was to determine the incidence of postoperative facial palsy after tumor surgery, and to investigate clinical and radiographic risk factors.

METHODS
A retrospective analysis was conducted at a single large pediatric hospital. Clinical, radiographic, and histological data were examined in children who were surgically treated for posterior fossa tumors between May 1, 1994, and June 1, 2011. The incidence of postoperative facial weakness was documented. A multivariate logistic regression model was used to analyze the predictive ability of clinicoradiological variables for facial weakness.

RESULTS
A total of 163 patients were included in this study. The average age at surgery was 7.4 ± 4.7 years, and tumor pathologies included astrocytoma (44%), medulloblastoma (36%), and ependymoma (20%). The lesions of 27 patients (17%) were considered high grade in nature. Thirteen patients (8%) exhibited preoperative symptoms of facial palsy. The overall incidence of postoperative facial palsy was 26% (43 patients), and the incidence of new postoperative facial palsy in patients without preoperative facial weakness was 20% (30 patients). The presence of a preoperative facial palsy had a large and significant effect in univariate analysis (OR 11.82, 95% CI 3.07–45.44, p < 0.01). Multivariate logistic regression identified recurrent operation (OR 4.45, 95% CI 1.49–13.30, p = 0.01) and other preoperative cranial nerve palsy (CNP; OR 3.01, 95% CI 1.24–7.29, p = 0.02) as significant risk factors for postoperative facial weakness.

CONCLUSIONS
Facial palsy is a risk during surgical resection of posterior fossa brain tumors in the pediatric population. The study results suggest that the incidence of new postoperative facial palsy can be as high as 20%. The presence of preoperative facial palsy, an operation for recurrent tumor, and the presence of other preoperative CNPs were found to be significant risk factors for postoperative facial weakness.
PROGRAM PENGAJARAN DAN PELATIHAN BAHASA INGGRIS DAN MATEMATIKA DASAR DI YAYASAN AL KAMILAH KELURAHAN SERUA KECAMATAN BOJONGSARI KOTA DEPOK
Authors: Priyadi Eko Sasongko , Fitriyah Fitriyah , Suryani Eny , Juitania Juitania 
Published: March 2021

Salah satu permasalahan yang dihadapi oleh masyarakat marginal di pinggiran kota, baik marginal secara ekonomi maupun marginal akses sumber daya adalah terbatasnya akses pada dunia pendidikan. Ketidakmampuan ekonomi dan jauhnya sekolah umum sebagai sarana formal pendidikan menyebabkan mereka memiliki keterbatasan untuk mendapatkan salah satu haknya. Dalam jangka panjang, kondisi ini dapat berakibat pada rendahnya tingkat mobilitas vertikal untuk mendapatkan kehidupan yang lebih baik di masa datang. Sebagai salah satu metode untuk ikut mengatasi permasalahan ini, beberapa staf pengajar pada Prodi Akuntansi Universitas Pamulang melaksanakan program pengajaran dan pelatihan Bahasa Inggris dan Matematika Dasar di Yayasan Al Kamilah, Bojongsari Kota Depok. Program ini dikeman menjadi salah satu wujud dari pelaksanan tri darma perguruan tinggi yakni Pengabdian Kepada Masyarakat.. Kata-kata kunci: Pengajaran, Pelatihan, Bahasa Inggris, Matematika Dasar
Kepahlawanan dalam Lagu-Lagu Perjuangan Nahdlatul Wathan Karya Hamzanwadi
Authors: Karmilawati Karmilawati 
Published: March 2021

This study aims to describe the forms of the heroes' characteristics and describe the heroic messages contained in the struggle songs of Nahdlatul Wathan (NW) by T.G.K.H. Muhammad Zainuddin Abdul Madjid (also known as Hamzanwadi). This research method is descriptive qualitative with content analysis technique which focuses research on the latent content of song texts as research data. This technique is done by reading, recording, and coding, which determines the themes of each form and the heroic message found in each song. The results of this study indicate that the form of heroism contained in the songs of struggle is the attitude of love of knowledge which is realized by diligently demanding knowledge, as well as the attitude of love for religion and nation which is realized through willingness to fight. The heroic message found is a call as well as an invitation to the ummah to have a noble character that is based on the knowledge of the realization of good relations between humans and God, humans and humans, and humans with nature.
KOHESI DAN KOHERENSI DALAM NOVEL KKN DI DESA PENARI KARYA SIMPLEMAN DAN IMPLIKASINYA TERHADAP PEMBELAJARAN BAHASA INDONESIA DI SMA
Authors: Wati Ismi Isma , Mulyati Sri Mulyati , Khotimah Khusnul Khotimah 
Published: March 2021

Cohesion and coherence have an important role in writing essays, both those that will write or those that have become essays. Therefore this study aims to determine the use of cohesion and coherence in the KKN novel in Penari Village. The object of this research is the KKN novel in Penari Village by Simpleman. The subject of this research is the sentence which contains the type of cohesion and coherence in the KKN novel in Penari Village by Simpleman. The approach used is a qualitative approach. A qualitative approach is an approach that presents data in the form of sentences. The design of this research is by collecting data, then the data is grouped according to the use of cohesion and coherence types, then the data is analyzed and presented in an informal form. Data collection techniques using reading techniques and note taking techniques. The technique of presenting the results of the analysis using informal techniques. Informal techniques are techniques that present data in the form of common words that are easily understood by the reader.
The results of this study are grammatical cohesion, lexical cohesion and coherence types. Grammatical cohesion includes: reference, substitution, ellipsis, and conjunction. The use of lexical cohesion are of two types namely, repetition and collocation. The use of coherence there are five relationships, namely: the sum relationship, the sequential relationship, the resistance relationship, the causal relationship, and the time relationship.
A comparative analysis of international health technology assessments for novel gene silencing therapies: patisiran and inotersen
Authors: Iannazzo Sergio 
Published: March 2021

Objectives: Using the case study of patisiran and inotersen, we conducted a narrative comparative analysis of the health technology assessment (HTA) agency appraisals of these two first-in-class transthyretin gene silencers, which represent exceptional advances in the treatment of hereditary transthyretin-mediated (hATTR) amyloidosis, a rare and multisystemic disease. Despite the impact of each product on the treatment landscape, the majority of HTAs are only considered standard of care as a comparator, resulting in a void of information and limited comprehension of the clinical and pharmacoeconomic differences between the two treatments.
Methods: A search was conducted internationally for HTA reports, and only instances where assessment decisions for both treatments were publicly available were included in the present analysis. The HTA reports were analyzed broadly for the assessment of clinical and pharmacoeconomic evidence. Only economic models considering both patisiran and inotersen were included in this analysis.
Results: A total of nine agencies with public assessment reports for both treatments were identified. HTA agency assessments for both treatments were essentially positive; however, differences were noted in the final recommendations, place in treatment or reimbursed indications, and in the narrative of the evaluations. Only the Canadian Agency for Drugs and Technologies in Health (CADTH) assessment for patisiran evaluated an economic model comparing the two treatments.
Conclusions: The differences summarized in this comparative analysis may provide a more comprehensive overview of the two treatments.