bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local Approach of Ductile Rupture Under Cyclic Loading Conditions
Authors: Remmal Al Mahdi , Marie Stéphane 
Published: December 2021

Abstract
Experiments have shown that ductile failure occurs sooner under cyclic loading conditions than under monotone ones. This reduction of ductility probably arises from an effect called “ratcheting of the porosity” that consists of a continued increase of the mean porosity during each cycle with the number of cycles. Improved micromechanical simulations confirmed this interpretation. The same work also contained a proof that Gurson's classical model for porous ductile materials does not predict any ratcheting of the porosity. In a recent work (Morin et al., 2017, “A Gurson-Type Layer Model for Ductile Porous Solids With Isotropic and Kinematic Hardening,” Int. J. Solids Struct., 118–119, pp. 167–178), the authors proposed a Gurson-type “layer model” better fit than Gurson's original one for the description of the ductile behavior under cyclic loading conditions, using the theory of sequential limit analysis. A very good agreement was obtained between the model predictions and the results of the micromechanical simulations for a rigid-hardenable material. However, the ratcheting of the porosity is a consequence of both hardening and elasticity, and sequential limit analysis (Yang, 1993, “Large Deformation of Structures by Sequential Limit Analysis,” Int. J. Solids Struct., 30(7), pp. 1001–1013; Leu, 2007, “Analytical and Numerical Investigation of Strain-Hardening Viscoplastic Thick-Walled Cylinders Under Internal Pressure by Using Sequential Limit Analysis,” Comput. Methods Appl. Mech. Eng., 196(25–28), pp. 2713–2722; Leblond et al., 2018, “Classical and Sequential Limit Analysis Revisited,” C. R. Méc., 346(4), pp. 336–349.) is strictly applicable in the absence of elasticity. In this work, a proposal is made to take into account elasticity in the layer model through the definition of a new objective stress rate leading to an accurate expression of the porosity rate accounting for both elasticity and plasticity. This proposal is assessed through comparison of its predictions with the results of some new micromechanical simulations performed for matrices exhibiting both elasticity and all types of hardening. Finally, a comparison of the predictions regarding finite element modeling of pipes loaded cyclically is proposed.
Boundary Slip-Induced Temperature Rise and Film Thickness Reduction Under Sliding/Rolling Contact in Thermal Elastohydrodynamic Lubrication
Authors: Meng Xianghua , Wang Jing , Nagayama Gyoko 
Published: December 2021

Abstract
Temperature rise and film thickness reduction are the most important factors in elastohydrodynamic lubrication (EHL). In the EHL contact area, interfacial resistances (velocity/thermal slips) induced by the molecular interaction between lubricant and solid become significant due to the large surface/volume ratio. Although the velocity slip has been investigated extensively, less attention has been paid on the thermal slip in the EHL regime. In this study, numerical simulations were conducted by applying three cases of boundary slips to surfaces under sliding/rolling contacts moving in the same direction for the Newtonian thermal EHL. We found that the coupled velocity/thermal slips lead the most significant temperature rise and film thickness reduction among the three cases. The velocity slip results in a lower temperature in the lubricant and solids, whereas the thermal slip causes a temperature rise in the entire contact area in the lubricant as the film thickness decreases simultaneously. Furthermore, the effect of thermal slip on lubrication is more dominant than that of velocity slip, which increases the entrainment velocity or slide–roll ratio.
Starving Your Performance? Reduced Preexercise Hunger Increases Resistance Exercise Performance
Authors: Naharudin Mohamed Nashrudin , Yusof Ashril , Clayton David J. , James Lewis J. 
Published: December 2021

Background: Preexercise food intake enhances exercise performance due, in part, to the provision of exogenous carbohydrate. Food intake also suppresses hunger, but the specific influence of hunger on exercise performance has not been investigated. This study aimed to manipulate hunger by altering preexercise meal viscosity to examine whether hunger influences performance. Methods: Sixteen resistance-trained males completed 2 experimental trials ingesting either high viscosity semisolid (SEM) and low viscosity liquid (LIQ) carbohydrate-containing meals 2 hours before performing 4 sets of back squat (85 [22] kg) and bench press (68 [13] kg) to failure at 90% 10-repetition maximum. Subjective hunger/fullness as well as plasma concentrations of glucose, insulin, ghrelin, and peptide tyrosine–tyrosine were measured before and periodically after the meal. Repetitions completed in sets were used to determine exercise performance. Results: Hunger was lower, and fullness was greater during SEM compared with LIQ immediately before and during exercise (P < .05). Total repetitions completed for back squat were approximately 10% greater in SEM (SEM 57 [9]; LIQ 51 [7] repetitions; P = .001) with no difference in bench press repetitions (SEM 48 [11]; LIQ 48 [10] repetitions; P = .621). Postprandial glucose concentrations were greater during LIQ (12% increase in peak glucose) but were similar throughout exercise. Conclusion: This study demonstrates that exercise performance in back squat was increased in the SEM trial concomitant to a reduction in hunger. Therefore, this study provides novel data that suggest that exercise performance might be influenced by hunger, at least for resistance exercise.
Social Determinants of Health and 30-Day Readmissions Among Adults Hospitalized for Heart Failure in the REGARDS Study
Authors: Sterling Madeline R. , Ringel Joanna Bryan , Pinheiro Laura C. , Safford Monika M. , Levitan Emily B. , Phillips Erica , Brown Todd M. , Nguyen Oanh K. , Goyal Parag 
Published: December 2021

Background:
It is not known which social determinants of health (SDOH) impact 30-day readmission after a heart failure (HF) hospitalization among older adults. We examined the association of 9 individual SDOH with 30-day readmission after an HF hospitalization.

Methods and Results:
Using the REGARDS study (Reasons for Geographic and Racial Differences in Stroke), we included Medicare beneficiaries who were discharged alive after an HF hospitalization between 2003 and 2014. We assessed 9 SDOH based on the Healthy People 2030 Framework: race, education, income, social isolation, social network, residential poverty, Health Professional Shortage Area, rural residence, and state public health infrastructure. The primary outcome was 30-day all-cause readmission. For each SDOH, we calculated incidence per 1000 person-years and multivariable-adjusted hazard ratios of readmission. Among 690 participants, the median age was 76 years at hospitalization (interquartile range, 71–82), 44.3% were women, 35.5% were Black, 23.5% had low educational attainment, 63.0% had low income, 21.0% had zip code–level poverty, 43.5% resided in Health Professional Shortage Areas, 39.3% lived in states with poor public health infrastructure, 13.1% were socially isolated, 13.3% had poor social networks, and 10.2% lived in rural areas. The 30-day readmission rate was 22.4%. In an unadjusted analysis, only Health Professional Shortage Area was significantly associated with 30-day readmission; in a fully adjusted analysis, none of the 9 SDOH were individually associated with 30-day readmission.

Conclusions:
In this modestly sized national cohort, although prevalent, none of the SDOH were associated with 30-day readmission after an HF hospitalization. Policies or interventions that only target individual SDOH to reduce readmissions after HF hospitalizations may not be sufficient to prevent readmission among older adults.
Precancer and cancer-associated depression and anxiety among older adults with blood cancers in the United States
Authors: Kuczmarski Thomas M. , Jaung Tim , Mancuso Claire E. , Mozessohn Lee , Roemer Lizabeth , Abel Gregory A. , Odejide Oreofe O. 
Published: December 2021

Abstract
For patients with blood cancers, comorbid mental health disorders at diagnosis likely affect the entire disease trajectory, as they can interfere with disease information processing, lead to poor coping, and even cause delays in care. We aimed to characterize the prevalence of depression and anxiety in patients with blood cancers. Using the Surveillance, Epidemiology, and End Results-Medicare database, we identified patients ≥67 years old diagnosed with lymphoma, myeloma, leukemia, or myelodysplastic syndromes between 2000 and 2015. We determined the prevalence of precancer depression and anxiety and cancer-associated (CA) depression and anxiety using claims data. We identified factors associated with CA-depression and CA-anxiety in multivariate analyses. Among 75 691 patients, 18.6% had at least 1 diagnosis of depression or anxiety. Of the total cohort, 13.7% had precancer depression and/or precancer anxiety, while 4.9% had CA-depression or CA-anxiety. Compared with patients without precancer anxiety, those with precancer anxiety were more likely to have subsequent claims for CA-depression (odds ratio [OR] 2.98; 95% CI 2.61-3.41). Other factors associated with a higher risk of CA- depression included female sex, nonmarried status, higher comorbidity, and myeloma diagnosis. Patients with precancer depression were significantly more likely to have subsequent claims for CA-anxiety compared with patients without precancer depression (OR 3.01; 95% CI 2.63-3.44). Female sex and myeloma diagnosis were also associated with CA-anxiety. In this large cohort of older patients with newly diagnosed blood cancers, almost 1 in 5 suffered from depression or anxiety, highlighting a critical need for systematic mental health screening and management for this population.
Airborne environmental DNA metabarcoding detects more diversity, with less sampling effort, than a traditional plant community survey
Authors: Johnson Mark D. , Fokar Mohamed , Cox Robert D. , Barnes Matthew A. 
Published: December 2021

AbstractBackgroundAirborne environmental DNA (eDNA) research is an emerging field that focuses on the detection of species from their genetic remnants in the air. The majority of studies into airborne eDNA of plants has until now either focused on single species detection, specifically only pollen, or human health impacts, with no previous studies surveying an entire plant community through metabarcoding. We therefore conducted an airborne eDNA metabarcoding survey and compared the results to a traditional plant community survey.ResultsOver the course of a year, we conducted two traditional transect-based visual plant surveys alongside an airborne eDNA sampling campaign on a short-grass rangeland. We found that airborne eDNA detected more species than the traditional surveying method, although the types of species detected varied based on the method used. Airborne eDNA detected more grasses and forbs with less showy flowers, while the traditional method detected fewer grasses but also detected rarer forbs with large showy flowers. Additionally, we found the airborne eDNA metabarcoding survey required less sampling effort in terms of the time needed to conduct a survey and was able to detect more invasive species than the traditional method.ConclusionsOverall, we have demonstrated that airborne eDNA can act as a sensitive and efficient plant community surveying method. Airborne eDNA surveillance has the potential to revolutionize the way plant communities are monitored in general, track changes in plant communities due to climate change and disturbances, and assist with the monitoring of invasive and endangered species.
Variations in pain prevalence, severity, and analgesic use by duration of survivorship: a cross-sectional study of 505 post-treatment head and neck cancer survivors
Authors: Ren Jenny L. , Rojo Raniv D. , Perez Joy Vanessa D. , Yeung Sai-Ching J. , Hanna Ehab Y. , Reyes-Gibby Cielito C. 
Published: December 2021

Abstract
Background
Studies suggest a high prevalence of pain in head and neck cancer (HNC) patients at diagnosis, during and after treatment; however, these studies had small sample sizes and did not comprehensively assess factors known to influence pain. We surveyed a large cohort of HNC survivors to determine variations in the prevalence of pain, its treatment and management by duration of survivorship, and assessed a comprehensive list of risk factors.

Methods
A cross sectional survey of post-treatment survivors of HNC during routine follow-up clinic visits.

Results
A total of 505 HNC survivors with a median follow up of 3 years from cancer diagnosis were included in the study. Overall, 45% (n = 224) reported pain and 14.5, 22 and 7% reported use of prescribed pain medication, over-the-counter pain medication and alternative pain therapies, respectively. Prevalence of severe pain was 7.3% and did not vary significantly by years of survivorship (< 1 year = 5.7%; 1 to < 3 years = 7.1%; 3 to < 8 years = 7.6%; 8 years or more =9.7%; P = 0.392). However, use of prescribed pain medication significantly varied by years of survivorship (< 1 year = 45.7%; 1 to < 3 years = 24.6%; 3 to < 8 years = 18.9; 8 years or more = 18.3%; p < 0.001). Of note, a significant proportion of survivors reported moderate to severe pain (moderate to severe = 55.7% versus none to mild = 44.3%) despite step 3 analgesic use (p < 0.001). Multivariable regression shows that recurrent disease (OR 6.77, 95% CI [1.44, 31.80]), history of chemotherapy (OR 6.00, 95% CI [2.10, 17.14]), and depression (Mild-moderate OR 5.30, 95% CI [2.20, 12.78]; Major OR 8.00, 95% CI [2.67, 23.96]) were significant risk factors for severe pain.

Conclusions
We identified a high prevalence of pain among HNC survivors and determined that analgesic use varied by the duration of survivorship. Therefore, routine surveillance for pain must be consistent throughout the course of survivorship.
Treatment patterns of patients diagnosed with major depressive disorder and suicidal ideation or attempt: a U.S. population-based study utilizing real-world data
Authors: Kern David M. , Cepeda M. Soledad , Wiegand Frank 
Published: December 2021

Abstract
Background
There is a knowledge gap regarding the treatment patterns of patients with major depressive disorder (MDD) who experience suicidal ideation or a suicide attempt (SI/SA).

Methods
Patients with SI/SA were identified from a large US-based claims database covering 84 million lives, during 1/1/2014–3/31/2020. Patients with MDD were indexed at their first diagnosis for SI/SA and followed up to 365 days. Treatment patterns were captured at the class level and included procedures of electroconvulsive therapy and transcranial magnetic stimulation, and pharmacotherapy including selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors, tricyclic antidepressants, other antidepressants, anxiolytics, hypnotics/sedatives, antipsychotics, psychostimulants, and lithium.

Results
There were 42,204 MDD + SI/SA patients identified. In the year prior to the index event > 40% of individuals received an SSRI and more than one-third received an anxiolytic. Within 1 year following, 84.4% received ≥1 of the treatments of interest. Of those, 70.2% went on to a subsequent class-based regimen, 46.3% received a third, and 28.1% received ≥4. More than three-quarters of patients received multiple treatment classes simultaneously. SSRIs were the most common treatments during follow-up (61.9%), followed by other antidepressants (51.3%), anxiolytics (50.8%) and anticonvulsants (43.6%).

Conclusions
There was a large amount of variability and polypharmacy in the treatments received by MDD patients with SI/SA, and is much more complex than what has been previously observed in the general MDD population. Within one-year, many patients received four or more unique class-based regimens and most patients received treatments from multiple classes simultaneously, indicating the high unmet medical need and therapy refractoriness of this patient population.
The pattern of alternative splicing in lung adenocarcinoma shows novel events correlated with tumorigenesis and immune microenvironment
Authors: Wang Gongjun , Qi Weiwei , Shen Liwei , Wang Shasha , Xiao Ruoxi , Li Wenqian , Zhang Yuqi , Bian Xiaoqian , Sun Libin , Qiu Wensheng 
Published: December 2021

AbstractLung adenocarcinoma (LUAD) is the leading cause of cancer deaths worldwide due to the lack of early diagnostic markers and specific drugs. Previous studies have shown the association of LUAD growth with aberrant alternative splicing (AS). Herein, clinical data of 535 tumor tissues and 59 normal tissues were extracted from The Cancer Genome Atlas (TCGA) database. Each sample was analyzed using the ESTIMATE algorithm; a comparison between higher and lower score groups (stromal or immune) was made to determine the overall- and progression-free survival-related differentially expressed AS (DEAS) events. We then performed unsupervised clustering of these DEASs, followed by determining their relationship with survival rate, immune cells, and the tumor microenvironment (TME). Next, two prognostic signatures were developed using bioinformatics tools to explore the prognosis of cases with LUAD. Five OS- and six PFS-associated DEAS events were implemented to establish a prognostic risk score model. When compared to the high-risk group (HRG), the PFS and OS of the low-risk group (LRG) were found to be considerable. Additionally, a better prognosis was found considerably associated with the ESTIMATE score of the patients as well as immune cells infiltration. Our analysis of AS events in LUAD not only helps to clarify the tumorigenesis mechanism of AS but also provides ideas for revealing potential prognostic biomarkers and therapeutic targets.
Influence of nocturnal hypoxemia on follow-up course after type B acute aortic syndrome
Authors: Delsart Pascal , Soquet Jerome , Pierache Adeline , Dedeken Maxime , Fry Stephanie , Mallart Anne , Pontana François , Azzaoui Richard , Juthier Francis , Sobocinski Jonathan , Mounier-Vehier Claire 
Published: December 2021

Abstract
Introduction
Association between sleep nocturnal breathing disorders and acute aortic syndrome (AAS) has been described but mid-term data are scarce.

Objectives
We assessed the prognostic value of sleep apnea parameters and their relationship with aortic morphology after the onset of a type B AAS.

Methods
Between January 2010 and January 2018, sleep apnea screening in post type B AAS was prospectively performed. The association of sleep apnea parameters with aortic morphology and aortic expansion during follow-up was studied.

Results
Over the 8-year-study period, 103 patients were included, with a mean age of 57.8 ± 12.1 years old. Median follow-up was 25.0 months (11.0–51.0). Thirty-two patients (31%) required aortic stenting during the acute phase. In patients treated by aortic stenting, the descending thoracic aortic diameter was positively associated with a higher percentage of nocturnal time of saturation ≤ 90% after adjustment (p = 0.016). During follow-up, the nocturnal time of saturation ≤ 90% in patients treated by medical therapy was the only parameter associated with significant aortic expansion rate (r = 0.26, p = 0.04). Thirty-eight patients started and sustained nocturnal ventilation during follow-up. The association between aortic expansion rate and nocturnal time of saturation ≤ 90% did not persist during follow-up after adjustment on nocturnal ventilation initiation (r = 0.25, p = 0.056).

Conclusions
Nocturnal hypoxemia parameters are positively associated with the max onset aortic diameter and significant aortic growth after type B AAS. Nocturnal ventilation seems to mitigate aortic expansion during follow-up.
Intralesional nerve-sparing surgery versus non-surgical treatment for giant cell tumor of the sacrum
Authors: Tsukamoto Shinji , Ali Nikolin , Mavrogenis Andreas F. , Honoki Kanya , Tanaka Yasuhito , Spinnato Paolo , Donati Davide Maria , Errani Costantino 
Published: December 2021

Abstract
Background
There is no standard treatment for giant cell tumors of the sacrum. We compared the outcomes and complications in patients with sacral giant cell tumors who underwent intralesional nerve-sparing surgery with or without (neo-) adjuvant therapies versus those who underwent non-surgical treatment (denosumab therapy and/or embolization).

Methods
We retrospectively investigated 15 cases of sacral giant cell tumors treated at two institutions between 2005 and 2020. Nine patients underwent intralesional nerve-sparing surgery with or without (neo-) adjuvant therapies, and six patients received non-surgical treatment. The mean follow-up period was 85 months for the surgical group (range, 25–154 months) and 59 months (range, 17–94 months) for the non-surgical group.

Results
The local recurrence rate was 44% in the surgical group, and the tumor progression rate was 0% in the non-surgical group. There were two surgery-related complications (infection and bladder laceration) and three denosumab-related complications (apical granuloma of the tooth, stress fracture of the sacroiliac joint, and osteonecrosis of the jaw). In the surgical group, the mean modified Biagini score (bowel, bladder, and motor function) was 0.9; in the non-surgical group, it was 0.5. None of the 11 female patients became pregnant or delivered a baby after developing a sacral giant cell tumor.

Conclusions
The cure rate of intralesional nerve-sparing surgery is over 50%. Non-surgical treatment has a similar risk of complications to intralesional nerve-sparing surgery and has better functional outcomes than intralesional nerve-sparing surgery, but patients must remain on therapy over time. Based on our results, the decision on the choice of treatment for sacral giant cell tumors could be discussed between the surgeon and the patient based on the tumor size and location.