bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge and Partnerships for Sustainability and Equality
Authors: Habib Adam 
Published: September 2021

AbstractWe live in interesting, but dangerous times; our world today is as unequal as it was before World War I and II. We are increasingly becoming as socially and politically polarized as we were then. Right-wing populist and nativist parties stalk all of our lands, deepening divides among our communities both nationally and internationally. Political and economic elites are paralyzed about what to do, or at least have not been able to marshal the will to undertake what needs to be done.
Post-COVID-19: A Time of Opportunity for Asian Universities
Authors: Woon Eden Y. 
Published: September 2021

AbstractBy the end of 2019, IAU member universities were already grappling with a variety of issues and knew that 2020 was going to be a challenging year. But many of them were still optimistic and looked forward to IAU’s 70th Anniversary Year when universities would continue to push forward the frontiers of knowledge and play an increasing role of providing young people an understanding of the world beyond their hometown. And the key of this optimism was based on increased internationalization.
Planar solutions of higher-spin theory. Part I. Free field level
Authors: Didenko V. E. , Korybut A. V. 
Published: August 2021

Abstract
Many black hole solutions of General Relativity are known to be linearly exact. This opens a way to study them in gauge theories that apart from gravity contain fields of higher spin s > 2. Starting with a black brane in AdS4 we find its free field higher- spin generalization that respects static and planar symmetry for all bosonic gauge fields s ≥ 0. The solution is found for both the higher-spin curvatures and potentials in the form suitable for further non-linear analysis and satisfies the multi copy relation.
Production of bioactive plant secondary metabolites through in vitro technologies—status and outlook
Authors: Wawrosch Christoph , Zotchev Sergey B. 
Published: September 2021

AbstractMedicinal plants have been used by mankind since ancient times, and many bioactive plant secondary metabolites are applied nowadays both directly as drugs, and as raw materials for semi-synthetic modifications. However, the structural complexity often thwarts cost-efficient chemical synthesis, and the usually low content in the native plant necessitates the processing of large amounts of field-cultivated raw material. The biotechnological manufacturing of such compounds offers a number of advantages like predictable, stable, and year-round sustainable production, scalability, and easier extraction and purification. Plant cell and tissue culture represents one possible alternative to the extraction of phytochemicals from plant material. Although a broad commercialization of such processes has not yet occurred, ongoing research indicates that plant in vitro systems such as cell suspension cultures, organ cultures, and transgenic hairy roots hold a promising potential as sources for bioactive compounds. Progress in the areas of biosynthetic pathway elucidation and genetic manipulation has expanded the possibilities to utilize plant metabolic engineering and heterologous production in microorganisms. This review aims to summarize recent advances in the in vitro production of high-value plant secondary metabolites of medicinal importance.Key points• Bioactive plant secondary metabolites are important for current and future use in medicine• In vitro production is a sustainable alternative to extraction from plants or costly chemical synthesis• Current research addresses plant cell and tissue culture, metabolic engineering, and heterologous production
Graphical abstract
Changes of retinal oxygen saturation during treatment of diabetic macular edema with a pre-defined regimen of aflibercept: a prospective study
Authors: Hasan Somar M. , Hammer Martin , Meller Daniel 
Published: September 2021

Abstract
Purpose
To study the effect of anti-VEGF therapy for diabetic macular edema (DME) on retinal oxygen saturation (O2S) and its correlation with functional and anatomical changes of retinal tissue.

Methods
An interventional prospective single group study. Included were 10 eyes of 10 patients with visually significant DME which received a fixed regimen of intravitreal aflibercept every 4 weeks for 5 months, followed by 3 injections every 8 weeks, and were controlled monthly. Visual acuity (VA), central retinal thickness (CRT), arterial (aO2S), venous (vO2S) and arterio-venous difference (AVdO2S) retinal oxygen saturation were noted monthly. Changes after 5th (V6) injection and on last follow-up (V12) were studied. Correlations of different parameters were analyzed.

Results
The aO2S did not change whereas vO2S decreased (62.2 ± 9.4 pre-op to 57.2 ± 10.5 on V6, p = 0.03). This remained unchanged at 59.4 ± 13.2 on V12 (p = 0.2) and was accompanied by an increase of AVdO2S (40.8 ± 8.3 pre-op to 44.8 ± 10.6, p = 0.03 on V6) which was followed by a non-significant decrease to 41.8 ± 11.3 on V12 (p = 0.06). We found no correlation between BCVA and aO2S. However, mild correlation between BCVA and both vO2S and AVdO2S (r = −0.2 p = 0.035 and r = 0.185 p = 0.05 respectively) was found. No correlation was found between CRT and aO2S, vO2S, or AVdO2S.

Conclusions
During DME treatment with fixed regimen of intravitreal aflibercept over 11 months, we observed a reduction of vO2S and increase of AVdO2S which correlated with BCVA but not CRT. This could be explained by increasing consumption of O2S in the central retina and, possibly, by re-perfusion process.
Evaluation of macular blood flow after intermittent intravenous infusion of high-dose corticosteroids (pulse therapy) in patients with thyroid-associated orbitopathy (TAO) using angio-OCT
Authors: Del Noce Chiara , Roda Matilde , Ferro Desideri Lorenzo , Traverso Carlo E. , Vagge Aldo 
Published: September 2021

Abstract
Purpose
The aim of this study is to evaluate the changes in macular blood flow index (BFI) in patients with moderate to severe thyroid-associated orbitopathy (TAO) before and after pulse therapy and their relationship with clinical features and disease activity using angio-OCT technology.

Methods
We analyzed twenty-four eyes. Every patient underwent a complete eye examination and angio-OCT analysis (OCT Topcon ImageNet 6; DRI OCT Triton, Topcon Corporation) before (T0) and two months (T2) after pulse therapy. We analyzed macular vascular blood flow in four angiographic levels: superficial plexus (SP), deep plexus (DP), external retina (ER), and choriocapillaris (CC). We used the clinical activity score (CAS) score to define TAO as moderate or severe.

Results
Macular BFI significantly increased at T2 in the DP, ER, and CC (p < 0.01). CAS score (5.8 ± 0.8 vs. 3.9 ± 0.9, p < 0.01) and Hertel exophthalmometry values (22.6 ± 2.3 mm vs. 21.2 ± 2,5 mm, p < 0.01) improved for all patients at T2 compared T0. Mean IOP increased from 13.3 ± 2.8 mmHg to 14.3 ± 2.1 mmHg (p < 0.01). No correlation was found between CAS score and macular BFI in all the analyzed levels.

Conclusions
Pulse therapy treatment can change macular BFI. In particular, two months alter pulse therapy, all the patients show an increase in macular vascular blood flow in each angiographic level. According to our results, angio-OCT analysis of the macular BFI may be a useful tool in the follow-up of TAO patients after pulse therapy.
Minimally invasive adrenalectomy for large pheochromocytoma: not recommendable yet? Results from a single institution case series
Authors: Arolfo Simone , Giraudo Giuseppe , Franco Caterina , Parasiliti Caprino Mirko , Seno Elisabetta , Morino Mario 
Published: September 2021

Abstract

Background

Minimally invasive adrenalectomy represents the treatment of choice of pheochromocytoma (PCC). For large or invasive PCCs, an open approach is currently recommended, in order to ensure complete tumor resection, prevent tumor rupture, avoid local recurrence, and limit perioperative hemodynamic instability. The aim of this study is to analyze perioperative outcomes of laparoscopic adrenalectomies (LAs) for large adrenal PCCs.

Methods

All consecutive LAs for PCC performed at a single institution between 1998 and 2020 were included. Two groups were defined: lesions larger (group 1) and smaller (group 2) than 5 cm. Short-term outcomes were compared in order to find any significant difference between the two groups.

Outcomes
One hundred fourteen patients underwent LA during the study period: 46 for lesions larger and 68 for lesions smaller than 5 cm. No significant differences were found in patients’ characteristics, median operative time, conversion rate, intraoperative hemodynamic and metabolic parameters, postoperative intensive care unit (ICU) admission rate, complications rate, and length of hospital stay. Long-term oncologic outcomes were similar, with a recurrence rate of 5.1% in group 1 vs 3.6% in group 2 (p = 1).

Conclusion
Minimally invasive adrenalectomy seems to be safe and effective even in large PCC. The recommendation to prefer an open approach for large PCCs should probably be reconsidered.
Effect of Personalized Messages Sent by a Health System’s Patient Portal on Influenza Vaccination Rates: a Randomized Clinical Trial
Authors: Szilagyi Peter G. , Albertin Christina S. , Casillas Alejandra , Valderrama Rebecca , Duru O. Kenrik , Ong Michael K , Vangala Sitaram , Tseng Chi-Hong , Humiston Sharon G. , Evans Sharon , Sloyan Michael , Bogard Jonathan E. , Fox Craig R. , Lerner Carlos 
Published: September 2021

Abstract
Background
Adult influenza vaccination rates are low. Tailored patient reminders might raise rates.

Objective
Evaluate impact of a health system’s patient portal reminders: (1) tailored to patient characteristics and (2) incorporating behavioral science strategies, on influenza vaccination rates among adults.

Design
Pragmatic 6-arm randomized trial across a health system during the 2019–2020 influenza vaccination season. The setting was one large health system—53 adult primary care practices.

Participants
All adult patients who used the patient portal within 12 months, stratified by the following: young adults (18–64 years, without diabetes), older adults (≥65 years, without diabetes), and those with diabetes (≥18 years).

Interventions
Patients were randomized within strata to either (1) pre-commitment reminder alone (1 message, mid-October), (2) pre-commitment + loss frame messages, (3) pre-commitment + gain frame messages, (4) loss frame messages alone, (5) gain frame messages alone, or (6) standard of care control. Patients in the pre-commitment group were sent a message in mid-October, asking if they planned on getting an influenza vaccination. Patients in loss or gain frame groups were sent up to 3 portal reminders (late October, November, and December, if no documented influenza vaccination in the EHR) about importance and safety of influenza vaccine.

Main Measures
Receipt of 1 influenza vaccine from 10/01/2019 to 03/31/2020.

Key Results
196,486 patients (145,166 young adults, 29,795 older adults, 21,525 adults with diabetes) were randomized. Influenza vaccination rates were as follows: for young adults 36.8%, for older adults 55.6%, and for diabetics 60.6%. On unadjusted and adjusted (for age, gender, insurance, race, ethnicity, and prior influenza vaccine history) analyses, influenza vaccination rates were not statistically different for any study group versus control.

Conclusions
Patient reminders sent by a health system’s patient portal that were tailored to patient demographics (young adults, older adults, diabetes) and that incorporated two behavioral economic messaging strategies (pre-commitment and loss/gain framing) were not effective in raising influenza vaccination rates.

Trial Registration
This trial was registered with ClinicalTrials.gov (NCT04110314).
Impact of olive mill wastewater (OMW) on the soil hydraulic and solute transport properties
Authors: Comegna A. , Dragonetti G. , Kodesova R. , Coppola A. 
Published: September 2021

AbstractThe Mediterranean area concentrates the world’s largest production area of olive oil. The olive oil industry represents, in this basin, one of the leading sectors of the agri-food economy. Olive mill water (OMW) is the principal waste effluent produced by the olive oil industry. Due to its high pollution load, this aqueous by-product cannot be directly disposed of in domestic wastewater treatment plants (especially those with a biological treatment unit). Untreated OMW is currently used for agronomic purposes in several countries, mainly because it is rich in valuable plant nutrients. However, OMW is characterized by toxic phenols, high organic matter, high salinity, suspended solids and several other components that may have possible negative effects on chemical and physical soil properties, as well as soil biological activities. In the present research, we focused on the effects of OMW application on transport and hydraulic soil properties. Three distinct soils from a pedological point of view were selected and a series of laboratory steady-state miscible flow tests were conducted under saturated conditions, on both OMW-treated and -untreated soil columns. Tests were conducted on disturbed and undisturbed soil columns. The approach proposed by Kachanoski, based on soil impedance (Z) measurements via the time domain reflectometry (TDR) technique, was used to monitor the leaching experiments. The breakthrough curves (BTCs) exhibited different shapes that allowed the repercussions of OMW applications on soil transport behaviour to be distinguished. Several additional tests conducted on OMW-treated and -untreated soil cores to determine water retention curves (SWRCs) and saturated hydraulic conductivity Ks allowed us to infer the probable mechanisms involved in soil hydrological behaviour changes under OMW treatments. The results show that when OMW leaches into the soil immediately after its disposal there is little effect on the evaluated hydraulic and hydrodispersive properties. By contrast, we demonstrated that a short incubation period (i.e. a short contact time between OMW and soil) of 10 days is enough to exert a great influence on all the values determined (e.g. soil pore velocity v and Ks reduced by up to one order of magnitude). These effects were especially evident in undisturbed soil samples.
Graphic Abstract
Rational design of the inlet configuration of flow systems for enhanced mixing
Authors: Gao Yunhu , Zhu Di Fu , Han Yuan , Torrente-Murciano Laura 
Published: September 2021

AbstractHigh mass transfer rate is a key advantage of microreactors however, under their characteristic laminar flow, it is dominated by slow diffusion rather than fast convection. In this paper, we demonstrate how the configuration of the inlet, i.e. mixers, can promote different flow patterns to greatly enhance mixing efficiency downstream. A systematic evaluation and comparison of different widely adopted mixers as well as advanced designs is presented using a combination of computational fluid dynamics (CFD) and backward particle tracking to accurately calculate diffusion, in the absence of numerical diffusion (false diffusion). In the method, the convection contributed concentration profile is obtained by tracking sampling points from a cross-sectional plane to the inlet point, and diffusion is estimated subsequently. In conventional T- and Y-mixers, the shape of channel, circular or square, is key with only the latter promoting engulfment flow. In cyclone mixers, the resulting average inlet velocity, independent of Reynolds number or geometry, is the dominating design parameter to predict mixing efficiency. This work will serve as a guideline for the design of efficient flow systems with predicted mixing as a way of maximising selectivity and product quality.
Influence of dynamic properties on scaffoldings safety
Authors: Błazik-Borowa Ewa , Bęc Jarosław 
Published: September 2021

Abstract
Scaffoldings are used for works at height and in places that are hard to reach, which makes such works dangerous to employees and accidents occur frequently. Loads generated by scaffolding users cannot be avoided. Moving workers excite low-frequency (1–2 Hz) vibrations and scaffoldings as slender structures are prone to such dynamic action. The method for determining the probability of vibrations excitation is presented here. The quantity representing this probability is called the predictor of occurrence of a dangerous situation due to vibrations induced by a walking employee. The predictor of resonance with ith natural frequency requires an analysis of the scaffolding dynamic behavior. The frequencies and the natural mode shapes of vibrations were determined. Numerical dynamic simulations of the worker's movement on the penultimate decks of two scaffoldings were carried out, as well. Predictor analysis was made for single frequencies and combinations of frequency pairs. The predictor values calculated for the first frequency or combinations with it are the highest ones, however the probability of resonance is not only affected by the first frequency. To improve safety, the natural frequencies should be increased. For longitudinal vibrations, this can be done by adding more bracing or reducing lengths of anchors. Increasing the number of anchors gives good results in both directions. During scaffolding design of both typical and atypical constructions, one must determine the natural frequencies and then, if the first natural frequency is less than 4.0 Hz, perform a dynamic scaffolding analysis.
Racial Integration and the Problem of Relational Devaluation
Authors: Matthew D. C. 
Published: September 2021

AbstractThis article argues that blacks should reject integration on self-protective and solidarity grounds. It distinguishes two aspects of black devaluation: a ‘stigmatization’ aspect that has to do with the fact that blacks are subject to various forms of discrimination, and an aesthetic aspect (‘phenotypic devaluation’) that concerns the aesthetic devaluation of characteristically black phenotypic traits. It identifies four self-worth harms that integration may inflict, and suggests that these may outweigh the benefits of integration. Further, it argues that, while the integrating process may reduce stigmatization, there is less reason to think that it can do the same for phenotypic devaluation.
Local Legitimacy and Tax Policy: Qaids as Part of a Composite State in Colonial Tunisia
Authors: Perrier Antoine 
Published: September 2021

AbstractThe colonial history of Tunisia has long been dictated by colonial sources that made the qaid (an official in charge of fiscal attributions), from the viewpoint of the capital city, a local notable and often a prevaricator. This study proposes to reconsider the relationship between government and regional power in the colonial context by drawing on the recent work of Ottoman studies about provincial elites. The article studies the fiscal reforms of the interwar period in a cereal-growing region of Tunisia, relying on sources in Arabic produced by the qaids, namely the administrative correspondence between local authorities, the prime minister, and colonial controllers. This article describes the role of qaids in the negotiation between national law and local specificities and finally highlights the role of decentralization and a local way of thinking about the state in the 1930s. It contributes to colonial history and the history of taxation by highlighting the territorial fractures in North Africa and the agency of local actors under the protectorate.
Geographically Targeted Spending in Mixed-Member Majoritarian Electoral Systems
Authors: Catalinac Amy , Motolinia Lucia 
Published: September 2021

ABSTRACTCan governments elected under mixed-member majoritarian (mmm) electoral systems use geographically targeted spending to increase their chances of staying in office, and if so, how? Although twenty-eight countries usemmmelectoral systems, scant research has addressed this question. The authors explain howmmm’s combination of electoral systems in two unlinked tiers creates a distinct strategic environment in which a large party and a small party can trade votes in one tier for votes in the other tier in a way that increases the number of seats won by both. They then explain how governing parties dependent on vote trading can use geographically targeted spending to cement it. These propositions are tested using original data from Japan (2003–2013) and Mexico (2012–2016). In both cases, municipalities in which the supporters of governing parties split their ballots as instructed were found to have received more money after elections. The findings have broad implications for research onmmmelectoral systems, distributive politics, and the politics of Japan and Mexico.
L’oralité mise en scène dans la bande dessinée: marques phonologiques et morphosyntaxiques dans Astérix et Titeuf
Authors: Grutschus Anke , Kern Beate 
Published: September 2021

RésuméLa mise en scène du langage parlé est un élément central de la bande dessinée: les discours directs des protagonistes sont non seulement visuellement représentés par des bulles, mais leur langage se caractérise souvent aussi par les marques phonologiques et morpho-syntaxiques typiques de l’oral afin d’évoquer l’immédiat communicatif. Cet article se propose ainsi d’étudier, sur le plan phonologique, des phénomènes tels que les élisions, les aphérèses et même certaines marques prosodiques ainsi que, sur le plan morphosyntaxique, entre autres l’omission du ne de négation, les dislocations et l’absence du il impersonnel. On s’interrogera notamment sur les convergences entre l’oralité fictive des bandes dessinées et les résultats des études de l’oralité basées sur des corpus authentiques. L’analyse s’appuie sur un corpus de deux bandes dessinées francophones, comprenant un tome respectivement des séries Astérix et Titeuf. L’étude est basée sur une grille inspirée, entre autres, par la catégorisation des phénomènes de l’immédiat communicatif par Koch et Oesterreicher (2011) et complétée de manière inductive (corpus-driven). L’article montre que les deux sous-corpus révèlent des stratégies d’oralisation divergentes: alors que dans Astérix, on trouve un grand nombre de phénomènes phonologiques suprasegmentaux représentés, notamment au niveau de la typographie, Titeuf privilégie l’utilisation de marques morphosyntaxiques ainsi que de certains phénomènes phonologiques segmentaux.
Energetic Charged Particles in the Terrestrial Magnetosphere: Cluster/RAPID Results
Authors: Kronberg E. A. , Daly P. W. , Grigorenko E. E. , Smirnov A. G. , Klecker B. , Malykhin A. Yu. 
Published: September 2021

AbstractIn this work, we review the results of observations by the Cluster/Research with Adaptive Particle Imaging Detectors (RAPID) energetic charged particle detector (40 keV–1 MeV). The origin of energetic ions in the region upstream of the Earth's bow shock is compared under different solar wind conditions. We give a brief overview of the acceleration mechanisms of charged particles in the plasma sheet. Effective acceleration is associated with (multiple) interaction(s) of charged particles with multiscale magnetic structures and/or electromagnetic fluctuations, which are the consequences of reconnection or other plasma instabilities. The necessity of such acceleration mechanisms to reproduce the distributions of energetic particles on closed magnetic field lines is discussed. We review empirical models describing the distributions of charged particles. Several aspects of the dynamics of energetic particles during substorms and their influence on the dynamics of magnetic storms are shown. We advise to consider including the energetic particles at 40 keV in calculations of the plasma temperature and pressure during these dynamic processes.