bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Apolipoprotein(a) Phenotypes on Long-Term Renal Transplant Survival
Authors: WAHN FRIEDERIKE , DANIEL VOLKER , KRONENBERG FLORIAN , OPELZ GERHARD , MICHALK DIETRICH V. , QUERFELD UWE 
Published: April 2021

Abstract.
The long-term success of renal transplantation is limited because of chronic rejection (CR), which shows histologic parallels to atherosclerosis. Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerosis, but its role in CR has not been investigated. Plasma levels of Lp(a) are determined mainly by the inherited isoform (phenotype) of apolipoprotein(a) [apo(a)] and show an inverse correlation with the molecular weight of apo(a). Apo(a) isoforms were identified in frozen sera of 327 patients who received a renal transplant during 1982 to 1992. Long-term graft survival in recipients with high molecular weight (HMW) or low molecular weight (LMW) apo(a) phenotypes were compared retrospectively. Mean (95% confidence interval) transplant survival was 12.8 yr (range, 11.9 to 13.6 yr) in patients with HMW and 11.9 yr (range, 10.8 to 13.1 yr) in patients with LMW apo(a) phenotypes (P = 0.2065). In patients who were 35 yr or younger at the time of transplantation, mean transplant survival was more than 3 yr longer in recipients with HMW apo(a) phenotypes compared with those with LMW apo(a) phenotypes (13.2 yr [range, 12.1 to 14.4 yr] versus 9.9 yr (range, 8.5 to 11.5 yr); P = 0.0156). In a Cox's proportional hazards regression model, the presence of LMW phenotypes—but not gender, immunosuppression, or HLA mismatches—in young patients was associated with a statistically significant risk of CR (P = 0.0434). These retrospective data indicate that young renal transplant recipients with LMW apo(a) phenotypes have a significantly shorter long-term graft survival, regardless of the number of HLA mismatches, gender, or immunosuppressive treatment.
Identification of a Novel Nuclear Guanosine Triphosphate-Binding Protein Differentially Expressed in Renal Disease
Authors: LAPING NICHOLAS J. , OLSON BARBARA A. , ZHU YUAN 
Published: April 2021

Abstract.
A novel guanosine triphosphate—binding protein, chronic renal failure gene (CRFG), was discovered by differential display PCR to be regulated differentially in renal disease. Within the rat kidney, CRFG mRNA was localized to the outer medulla and was highly expressed in epithelial cells. The specific renal expression of CRFG mRNA in the outer medulla was reduced dramatically in several rat models of renal disease, including diabetic nephropathy, partial nephrectomy, ischemia, and anti-Thy1.1—induced nephritis. CRFG was localized selectively in the nucleus of human and rodent cells, as determined by immunocytochemistry and green fluorescence fusion protein. Cellular mRNA levels of CRFG were also increased after serum administration, when cells proliferate. These data suggest that CRFG may be involved in regulating guanosine triphosphate—dependent nuclear events that are associated with cell proliferation and that are important in normal renal function and essential for growth and development.
Chemokine Expression Precedes Inflammatory Cell Infiltration and Chemokine Receptor and Cytokine Expression during the Initiation of Murine Lupus Nephritis
Authors: LEMA GUILLERMO PÉREZ DE , MAIER HOLGER , NIETO ELENA , VIELHAUER VOLKER , LUCKOW BRUNO , MAMPASO FRANCISCO , SCHLO[Combining Diaeresis]NDORFF DETLEF 
Published: April 2021

Abstract.
Lupus nephritis is characterized by immune complex deposition and inflammatory cell infiltration. Therefore, the initiation and progression of lupus nephritis in MRL/MpJ Faslpr/lpr (MRL/lpr) mice were investigated, with a focus on the expression of several chemokines and chemokine receptors. Mice were monitored for proteinuria from 6 to 20 wk of age, and kidneys were examined every 2 wk by light microscopy, electron microscopy, and immunohistologic analyses. Furthermore, the expression of chemokines, chemokine receptors, and proinflammatory cytokines was analyzed in ribonuclease protection assays. MRL/lpr mice demonstrated increased expression of monocyte chemoattractant protein-1, regulated upon activation, normal T cell-expressed and -secreted protein, inducible protein of 10 kD, and macrophage inflammatory protein-1β at week 8. At that time point, levels of circulating and glomerular immune complexes were increased, and no proteinuria or histopathologic signs of renal damage could be observed. As assessed in immunohistochemical and in situ hybridization analyses, monocyte chemoattractant protein-1 and regulated upon activation, normal T cell-expressed and -secreted protein expression was preferentially located in the glomeruli and interstitium. Mononuclear cell infiltration of the kidney was observed by weeks 10 to 12. At week 12, the renal expression of chemokine receptor 1 (CCR1), CCR2, and CCR5 was increased, mice became proteinuric, and renal damage was histologically evident. Finally, the expression of proinflammatory cytokines was detected (weeks 12 to 14). In summary, (1) chemokines are upregulated before inflammatory cell infiltration, proteinuria, and kidney damage are observed; (2) chemokine generation is restricted to sites of subsequent inflammatory cell infiltration, i.e., glomeruli and interstitium; (3) chemokine receptor expression parallels mononuclear cell infiltration; and (4) proinflammatory cytokines are upregulated later, in parallel with inflammatory cell infiltration and the onset of proteinuria. These results support the hypothesis that chemokines initiate leukocyte infiltration and precede proteinuria and renal damage in MRL/lpr mice.
Increased Immunogenicity and Cause of Graft Loss of Old Donor Kidneys
Authors: FIJTER JOHAN W. DE , MALLAT MARKO J. K. , DOXIADIS ILIAS I. N. , RINGERS JAN , ROSENDAAL FRITS R. , CLAAS FRANS H. J. , PAUL LEENDERT C. 
Published: April 2021

Abstract.
Donor age was identified recently as a major factor that determines long-term outcome after transplantation, but the mechanism that is responsible for increased graft loss of old donor kidneys is unknown. The influence of donor age on graft survival was assessed retrospectively in 514 consecutive first cadaveric transplants that were treated with cyclosporine maintenance immunosuppression. Donor age ≥50 yr (relative risk [RR] = 1.7; 95% confidence interval [CI], 1.2 to 2.6), acute rejection (RR = 2.0; 95% CI, 1.3 to 3.0), and type of rejection (RR = 3.3; 95% CI, 2.0 to 5.3) had a significant impact on graft survival. However, when subsets of patients who entered subsequent intervals after transplantation were analyzed, donor age was not an independent predictive factor of graft loss. Donor age (RR = 1.53; 95% CI, 1.19 to 1.98), human leukocyte antigen-DR mismatch (RR = 2.28; 95% CI, 1.78 to 2.92), and recipient age (RR = 1.34; 95% CI, 1.05 to 1.72) were associated significantly with acute rejection episodes. Delayed graft function alone was not associated independently with the occurrence of early acute rejection (RR = 1.24; 95% CI, 0.96 to 1.61). The timing of the rejection episodes of old donor kidneys was not different, and the excess rejection prevalence was attributable entirely to interstitial (grade I) types of rejection. Interstitial rejection episodes in kidneys from old donors had a significant (P < 0.05) negative impact on graft survival. Beyond the first year, poor renal function and proteinuria were significant risk factors for graft loss, regardless of rejection. Our data fit best the hypothesis that increased graft loss of older donor kidneys results from an increased incidence of acute interstitial rejection episodes in the early posttransplantation months. It is proposed that kidneys from older donors are more immunogenic than kidneys from young donors and that acute rejection episodes result in functional deterioration. Contrary to interstitial rejection in kidneys from younger donors, kidneys from old donors seem to have an impaired ability to restore tissue.
Selective Cyclooxygenase-2 Inhibition Impairs Glomerular Capillary Healing in Experimental Glomerulonephritis
Authors: Kitahara Masashi , Eitner Frank , Ostendorf Tammo , Kunter Uta , Janssen Ulf , Westenfeld Ralf , Matsui Katsuyuki , Kerjaschki Dontscho , Floege Ju[Combining Diaeresis]rgen 
Published: April 2021

ABSTRACT.
Selective cyclooxygenase-2 (COX-2) inhibitors have anti-inflammatory activity and reduce proteinuria in experimental membranous glomerulonephritis. Antiangiogenic properties of COX-2 inhibitors were recently reported. Whether these properties are relevant to the glomerular healing process in inflammatory glomerular diseases was investigated. For evaluation of the effects of selective COX-2 inhibitors on the glomerular healing process in a rat model of mesangioproliferative glomerulonephritis (induced by anti-Thy 1.1 antibody), a selective COX-2 inhibitor (rofecoxib or celecoxib) or vehicle was administered daily from day 1 after disease induction until euthanasia on day 6. Additional nephritic rats were treated with rofecoxib or vehicle from day 1 to day 10 and were monitored until day 28. Selective COX-2 inhibition led to significant increases in mesangiolysis (up to +71%) on days 2 and 6 and in albuminuria (up to 3.1-fold) on day 6. This augmentation of glomerular capillary damage was associated with rarefaction of glomerular endothelial cells, whereas the proliferation and activation of mesangial cells were not affected. No significant effects on the glomerular influx of polymorphonuclear neutrophils or the infiltration and proliferation of monocytes/macrophages at day 2 were noted. These effects were independent of systemic hemodynamic features, because rofecoxib did not affect systolic BP on day 2 or 5. Nephritic rats treated with rofecoxib for 10 d demonstrated persistent glomerular injury at day 28, as indicated by increased albuminuria (10-fold) and mesangial type IV collagen deposition (+24%). In normal rats, 5-d administration of rofecoxib failed to induce albuminuria or morphologic renal damage. In conclusion, selective COX-2 inhibitors impair glomerular capillary repair after mesangiolysis in rats with anti-Thy 1.1 glomerulonephritis. These data suggest that selective COX-2 inhibitors should be used with caution among patients with inflammatory endocapillary glomerular disorders.
Implicaciones de los choques de prima de riesgo en una economía pequeña y abierta
Authors: Gil León José Mauricio , Suárez Cante Andrés Felipe 
Published: April 2021

En este artículo se pretende identificar el canal de transmisión de los choques de prima de riesgo en las diferentes variables macroeconómicas. Por tanto, se formula un modelo DSGE para una economía pequeña y abierta, que considera el comportamiento de los hogares, las decisiones de inversión de parte de las empresas, la función de reacción del banco central y la dinámica de las diferentes variables externas, tales como la variación de los activos externos netos del país y el comercio exterior. El modelo se calibra con datos de la economía colombiana del periodo 2005-2017. En los resultados de la simulación se identifica la persistencia del shock de prima de riesgo en las variables endógenas que componen al modelo, y en especial se observan efectos sobresalientes del choque sobre el tipo de cambio, la tasa de interés y la inflación. Se concluye que el tamaño de la elasticidad de la prima de riesgo al endeudamiento externo domina la fuerza con la que inciden los shocks en la economía.
Hedgehog inhibitor in the treatment of basal cell skin cancer: case report
Authors: Musin Sh. I. , Sharafutdinova N. А. , Sultanbaev A. V. , Osokin S. V. , Ibragimov B. A. , Menshikov K. V. , Ayupov R. T. 
Published: April 2021

Background. In the structure of malignant neoplasms, basal cell skin cancer (BCC) occupies a leading position. In the initial stages of a malignant neoplasm, the main treatments are local treatment methods, both surgical and radiation. However, in about 1.3 % of cases, BCC can become locally or metastatic in which local treatment methods are limited. With the development of targeted drugs, such as the Hedgehog pathway inhibitor, the possibilities for effective and safe treatment of this category of patients have appeared.The objective is to present the clinical case of treating a patient with BCC who is receiving systemic therapy with a Hedgehog signaling pathway inhibitor.Case report. According to the patient, a tumor in the lower eyelid of the left eye appeared in 2000, did not seek medical help. In 2011, he applied to the clinic and was diagnosed with skin cancer of the lower eyelid of the left eye T2bN0M0. The patient refused the proposed treatment. Reapplied only in June 2017 already with a locally distributed process. The case is recognized as unresectable. From June 30, 2017 to September 4, 2017, he underwent a course of a radical program of radiotherapy, with a positive effect. 07/01/2019, he relapsed with a relapse of an orbital tumor on the left. From July 16, 2019, the patient began taking the drug wismodegib 150 mg once a day. Against the background of the treatment, control CT studies on 11/24/2019 and 11/03/2020 compared with CT data from 07/09/2019 reduced the volume of the tumor by 78 and 82 %. The patient currently continues to take wismodegib.Conclusion. The clinical case demonstrates successful treatment of locally advanced basal cell skin cancer with a Hedgehog signaling pathway inhibitor.
Own experience of "Glicifon" using as a local chemotherapy drug for the patients with basal-cell head&neck carcinoma
Authors: Reshetov D. N. 
Published: April 2021

Introduction.Skin cancer is the most common type among the cancer statistics. It accounts up to 14.2 % of all types of cancer. Basal cell cancer (BCC) is the most common among the skin cancers. Despite the possibilities of using different types of treatment BCC the long-term results are infavorable-the relapse rates are still high and cosmetic results are unsufficient. Using the local chemotherapy is alternative method of head&neck BCC treatment.The study objective. Efficency analysis of using «Glycifon» as a local chemotherapy drug for head&neck BCC. Materials and methods. The study included 24 patients with head&neck BCC who underwent local chemotherapy with "Glycifon" drug. 18 (75 %) patients had primary tumors, 6 (25 %) - relapsed tumors. 7 (29.2 %) patients had multicentre BCC. All patients received local chemotherapy by "Glycifon" according to recommended instructions.Results.79.2 % of patients had full regress of BCC after "Glycifon" local chemotherapy. Medium follow up time was 11.5 month. 2 patients (8.35) had to interrupt the treatment but for the intensive pain after the drug application. Other patients finished the therapy satisfactorily. No toxic reactions were observed. Inflammatory reactions in application zones were moderate and easily fixed. All patients who finished the therapy (100 %) we satisfied about the cosmetic results.Conclusion.Usage of "Glycifon" drug for local chemotherapy of head&neck DCC is effective, safe and cosmetic satisfied method. Possibility of using "Glycifon" in ambulatory treatment reduce the total medical & economic costs.
On Delineation of the Continental Shelf: Decision of the International Tribunal for the Law of the Sea on Delimitation of the Maritime Boundary between Bangladesh and Myanmar, 2012
Authors: Klyuchnikov A. Yu. 
Published: April 2021

With the development of technical capabilities for the exploration and exploitation of the continental shelf, the desire of coastal states to expand the area of their jurisdiction in the "underwater territory" (the territory of the seabed) increased. Thanks to the activism of the judges of the International Tribunal for the Law of the Sea, the concept of the continental shelf for the purposes of international maritime law has been significantly developed. As a result, the coastal states signatories to the 1982 Convention on the Law of the Sea were able to establish the outer limit of the continental shelf, which, under certain conditions, can extend even beyond 350 nautical miles from the baseline.Disputes between states on the continental shelf mainly arise in connection with the need to distinguish between marine areas rich in sources of living and non-living resources. In such cases, it may be necessary to delineate the continental shelf between adjacent States (with a common border) or located opposite each other, i.e. their delimitation under article 83 of the Convention on the Law of the Sea. The subject of the dispute is the external legal boundary of the continental shelf of the state, where it extends beyond 200 nautical miles from the baseline of that state (the continental shelf beyond 200 nautical miles), adjoins the area that is the common heritage of mankind, outside the jurisdiction of any of the states.On the issue of determining the limits of the continental shelf beyond 200 nautical miles, the decision of the International Tribunal for the Law of the Sea of 14.03.2012 "On delimitation of maritime boundary between Bangladesh and Myanmar" is of a precedent value, since no international court has previously addressed this issue.
IMPACT OF COVID-19 ON SOCIAL COHESION AND ROLE OF MUSLIM COMMUNITIES TO TACKLE THE CHALLENGE
Authors: Abbasi Muhammad Umar Riaz , Ejaz Tariq , Akhtar Shamshad 
Published: April 2021

Purpose of the study: This research is focused on examining the impact of Covid-19 on societal social cohesion. Furthermore, the role of Muslim communities in tackling the challenges has also been investigated in detail.
Methodology: The discussed research is conducted by detailed analysis of the related literature. This paper is thus based upon the secondary data gathered from different sources including newspapers, articles published in journals, books, and reports from diverse non-governmental, and governmental organizations.
Main Findings: The biggest challenge for the globe at this crucial time is isolation and social distancing as it has impacted the world at a large level. Social interaction is vital for human existence, and its absence leads to stressed, anxious, and depressed life. Also, it hampers the economic growth of the state. Muslim communities have been afflicted with various difficulties in the context of their religious matters due to this pandemic. They have even paused their major religious tasks like Pilgrimage, congregations, and Namaz-e-Jummah to prevent the people from deadly consequences of the pandemic.
Applications of this study: This study can be useful in examining the impacts of COVID-19 disease on social cohesion. Furthermore, it can be used in understanding the concept of Social cohesion according to the point of view of the Quran and Sunnah. Additionally, it aids in exploring the steps taken by the Islamic world in tackling this disease and its impacts on social togetherness.
The originality of this study: This is a comprehensive study on the impacts brought about by Covid-19 on social cohesion. Also, the role played by Muslim societies in handling the social challenges imposed by Covid-19 is the focus of this study. Moreover, this study encompasses the Islamic way and guidance by Quran and Sunnah to tackle the pandemic situations.
MEDIATED MODEL OF DIGITALIZED CORPORATIONS IN THE CONTEXT OF PRICE FAIRNESS AND CUSTOMER PERCEIVED QUALITY
Authors: Arshad Adnan , Danish Rizwan Qaiser , Hasnain Muhammad , Gill Aniqa , Saeed Sania 
Published: April 2021

Abstract
Purpose of the study: This research is conducted on the digital marketing industry flourished by digitalized corporations, based on their websites and different social media channels. In this study, we tried to determine the behavior of digitalized corporations in the context of price fairness and customer perceived quality. We also examined the trust of the digitalized corporations, satisfaction, and loyalty with the online portals.
Methodology: This study uses cross-sectional data of CEOs and other authorities of digitalized corporations. SPSS version 22 and AMOS version 21 are used for data analysis. Data is collected by distributing 400 questionnaires for this quantitative study. The convenience sampling technique is used for data collection.
Main Findings: After analyzing the collected data, we found that price fairness is a more favorable factor than customer perceived quality. Trust and customer satisfaction are also important factors to generate loyalty. If online portals make their policies friendly for the digitalized corporations in pricing, they can get many customers on their platform. Hence, they can get a high volume of business opportunities.
Novelty/Originality of the study: The previous research regarding social media is generally based on consumers’ behavior in favor of digitalized corporations, while we examined digitalized corporations' behavior regarding digital marketing techniques in the Pakistani context. The relationship between online portals and digitalized corporations was investigated.
Applications of the study: This study is significant for the digitalized corporations in observing the fair dealing of online portals in the context of perceived quality and fair pricing. Then digitalized corporations develop trust with these portals and finally become loyal. This study recommends online portals focus on their pricing policies to enhance customer satisfaction.
Application of Nanocomposit Of Al2O3/Activated Carbon Prepared by Hydrothermal Process for Phenol Removal
Authors: Allwar Allwar , Sari Meidita Kemala 
Published: April 2021

<p>Nancomposite of Al<sub>2</sub>O<sub>3</sub>/activated carbon was prepared from the mixture of alumina oxide (Al<sub>2</sub>O<sub>3</sub>) and activated carbon from palm oil shell under the mixture of aquabidest and ethanol (1:1). The mixture was treated by hydrothermal process at 250 <sup>o</sup>C for 3 h. Resulted Al<sub>2</sub>O<sub>3</sub>/ activated carbon was characterized using SEM/EDX for studying the morphology structure of activated carbon and composite showing a like flower structure attached on the surface. The chemical compositions were 73.18%, oxygen 23.72%, aluminium 2.30%, dan silica 2.00%. The efficiency of composite was investigated for removal of phenol in aqueous solution. The maximum adsorption of phenol was obtained at pH 2, adsorbent weight 2 g, contact time 60 min and phenol concentration 100 ppm.</p>