bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repositioning of fungal-based peptides as modulators of angiotensin-converting enzyme-related carboxypeptidase, SARS-coronavirus HR2 domain, and coronavirus disease 2019 main protease
Authors: Oso Babatunde Joseph , Ogidi Clement Olusola 
Published: September 2021

Abstract

Background and Objectives
Angiotensin-converting enzyme-related carboxypeptidase, SARS-Coronavirus HR2 Domain, and COVID-19 main protease are essential for the cellular entry and replication of coronavirus in the host. This study investigated the putative inhibitory action of peptides form medicinal mushrooms, namely Pseudoplectania nigrella, Russula paludosa, and Clitocybe sinopica, towards selected proteins through computational studies.

Materials and Methods
The respective physicochemical properties of selected peptides were predicted using ProtParam tool, while the binding modes and binding free energy of selected peptides toward proteins were computed through HawkDock server. The structural flexibility and stability of docked protein–peptide complexes were assessed through iMODS server.

Results
The peptides showed an optimum binding afinity with the molecular targets; plectasin from P. nigrella showed the highest binding free energy compared to peptides from R. paludosa and C. sinopica. Besides, molecular dynamic simulations showed all fungal-based peptides could influence the flexibility and stability of selected proteins.

Conclusion
The study revealed fungal-based peptides could be explored as functional modulators of essential proteins that are involved in the cellular entry of coronavirus.
2020 Chinese expert-based consensus on the diagnosis and treatment of connective tissue disease associated pulmonary arterial hypertension
Authors: Zhao Jiuliang , Wang Qian , Wang Qiang , Zhang Yongfeng , Zhang Na , Zhang Rong , Hao Yanjie , Jia Junfeng , Li Mengtao , Zeng Xiaofeng 
Published: September 2021

Abstract
Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue disease (CTD) and is one of the leading causes of morbidity and mortality among patients with this condition. To establish an expert-based consensus on the diagnosis and treatment of CTD-associated PAH, a multidisciplinary consensus development panel was established. The consensus panel is composed of 45 experts in rheumatology, cardiology, pulmonology, and radiology, most of whom are members of the Group of Pulmonary Vascular and Interstitial Lung Diseases (ILD) Associated with Rheumatic Diseases. The consensus development panel compiled 9 recommendations for the diagnosis and treatment of CTD-associated PAH. It covers screening, diagnosis, disease evaluation, risk assessment, the use of immunosuppressive agents, and PAH-specific therapy with a treat-to-target approach. The consensus is intended to facilitate decision-making and standardize the care of CTD-associated PAH in China.
The emerging challenge of pain in systemic sclerosis: Similarity to the pain experience reported by Sjőgren’s syndrome patients
Authors: De Luca Rossella , Maresca Marco , Orlandi Martina , Bruni Cosimo , Solanki Kamal , Wang Yukai , Lepri Gemma , Guiducci Serena , Melchiorre Daniela , Moggi-Pignone Alberto , Rossi Wanda , De Paulis Amato , Dzhus Marta , Matucci-Cerinic Marco , Bellando-Randone Silvia 
Published: September 2021

Abstract
In order to evaluate the importance of pain in systemic sclerosis (SSc), the characteristics of pain reported by patients with SSc were analyzed and compared with the characteristics of pain reported by patients with primary Sjőgren’s syndrome (pSS). Pain was reported by 56 patients (80%) in a group of 70 patients with SSc and by 25 patients (78%) in a group of 32 patients with pSS. Pain severity was assessed by the Pain Rating Index (PRI) and the Present Pain Intensity (PPI) of the McGill Pain Questionnaire (MPQ) and by values obtained by a visual analog scale (VAS) indicating the intensity of pain felt in the moment of the examination and the intensity of pain felt in the week preceding the moment of the examination. No significant difference was detected in the comparison of mean values of pain indices between patients with SSc and patients with pSS and in the comparison among subgroups of patients with SSc. The data indicate that pain is a frequent and important cause of suffering in SSc as in other chronic diseases. The association of different methods may be especially useful to obtain a careful evaluation of pain in clinical research.
Pengaruh Pendapatan, Pengetahuan Dan Kerentanan Penyakit Terhadap Willingness To Pay (WTP) Premi Jaminan Kesehatan Pada Pekerja Sektor Informal
Authors: Dwi Prakoso Anom 
Published: September 2021

Background:
The Indonesian Government's target of Universal Coverage or 100% Health Insurance participation by 2019 failed to be achieved, even until the end of October 2020. The failure of universal coverage resulted in BPJS Health's finances getting worse after experiencing a deficit. Informal sector workers are the most dominant sector that has not participated in the Health Insurance scheme, totaling 30,487,891 workers. Low income, uncertainty each month, and the increase in contributions resulted in a decrease in Willingness to pay Health Insurance contributions.
Research purposes:
The purpose of this study is to analyze the effect of income, knowledge, and disease susceptibility to the willingness to pay (WTP) of health insurance contributions to informal sector workers.
Method:
This cross-sectional research was conducted in Kudus Regency, Central Java in January-February 2020. Sampling used purposive sampling with a total of 200 informal sector workers who had not yet participated in BPJS Kesehatan. The dependent variable is a willingness to pay. The independent variables are income, knowledge, and disease susceptibility. Data collection using a questionnaire and data analysis with logistic regression.
Result:
Willingness To Pay health insurance contributions for informal sector workers increased in income ≥Rp 2,218,451 (b = 2.02; 95% CI = 1.01-3.55; p = 0.044), high knowledge (b = 4.64; 95% CI = 2.36-8.31; p <0.001), high disease susceptibility (b = 3.01; 95% CI = 0.26-5.75; p = 0.031).
Conclusion:
Income, knowledge, and disease vulnerability have a significant effect on the willingness to pay for health insurance contributions for informal sector workers.

Keywords: Universal Health Coverage; Willingness To Pay; Health Insurance; informal sector workers.
Faktor yang Mempengaruhi Perilaku Mahasiswi Kesehatan dalam Akses Informasi Hak Kesehatan Reproduksi pada Perempuan Disabilitas
Authors: Santy Irene Putri  
Published: September 2021

Background:
The role of health students in providing information about reproductive health is very important, especially regarding reproductive health rights for women with disabilities. This is crucial to do because women with disabilities are very vulnerable to violence and discrimination, especially in terms of reproductive health.
Objectives:
This study aimed to analyze the influence of knowledge and intention toward behavior of female health students in accessing information on reproductive health rights for women with disabilities.
Research Methods:
This was a quantitative study with a cross-sectional design. This study was conducted at the Midwifery Study Program at Tribhuwana Tunggadewi University Malang in October 2020. The sample size was 50 subjects, selected by simple random sampling technique. The dependent variable is the behavior of health female students in accessing information. The independent variables were knowledge and intention in access to information. Data collection using an online questionnaire. The data analysis technique used multiple linear regression.
Results:
The behavior of health female students in access to information was influenced by knowledge (b= 0.36, CI 95% = 0.12 to 0.60, p= 0.005), and intention in access to information (b= 0.45, CI 95% = 0.10 to 0.80, p= 0.014).
Conclusion:
Participants with good knowledge and high intention in access to information affect behavior in accessing information.

Keywords: health students; reproductive health rights; women with disabilities
Compactness Property of Fuzzy Soft Metric Space and Fuzzy Soft Continuous Function
Authors: Sabri Raghad I. 
Published: September 2021

The theories of metric spaces and fuzzy metric spaces are crucial topics in mathematics.
Compactness is one of the most important and fundamental properties that have been widely used in Functional Analysis. In this paper, the definition of compact fuzzy soft metric space is introduced and some of its important theorems are investigated. Also, sequentially compact fuzzy soft metric space and locally compact fuzzy soft metric space are defined and the relationships between them are studied. Moreover, the relationships between each of the previous two concepts and several other known concepts are investigated separately. Besides, the compact fuzzy soft continuous functions are studied and some essential theorems are proved.
The Dynamics of Biological Models with Optimal Harvesting
Authors: Al-Nassir Sadiq 
Published: September 2021

This paper aims to introduce a concept of an equilibrium point of a dynamical system which will call it almost global asymptotically stable. We also propose and analyze a prey-predator model with a suggested function growth in prey species. Firstly the existence and local stability of all its equilibria are studied. After that the model is extended to an optimal control problem to obtain an optimal harvesting strategy. The discrete time version of Pontryagin's maximum principle is applied to solve the optimality problem. The characterization of the optimal harvesting variable and the adjoint variables are derived. Finally these theoretical results are demonstrated with numerical simulations.
PFDINN: Comparison between Three Back-propagation Algorithms for Pear Fruit Disease Identification
Authors: Qassir Samar Amil 
Published: September 2021

The diseases presence in various species of fruits are the crucial parameter of economic composition and degradation of the cultivation industry around the world. The proposed pear fruit disease identification neural network (PFDINN) frame-work to identify three types of pear diseases was presented in this work. The major phases of the presented frame-work were as the following: (1) the infected area in the pear fruit was detected by using the algorithm of K-means clustering. (2) hybrid statistical features were computed over the segmented pear image and combined to form one descriptor. (3) Feed forward neural network (FFNN), which depends on three learning algorithms of back propagation (BP) training, namely Scaled conjugate gradient (SCG-BP), Resilient (R-BP) and Bayesian regularization (BR-BP), was used in the identification process. Pear fruit was taken as the experiment case during this work with three classifications of diseases, namely fire blight, pear scab, and sooty blotch, as compared to healthy pears. PFDINN framework was trained and tested using 2D pear fruit images collected from the Fruit Crops Diseases Database (FCDD). The presented framework achieved 94.6%, 97.3%, and 96.3% efficiency for SCG-BP, R-BP, and BR-BP, respectively. An accuracy value of 100% was achieved when the R-BP learning algorithm was trained for identification.
PENGARUH KUALIFIKASI PENDIDIKAN TERHADAP PENGETAHUAN GURU MATEMATIKA DALAM MENYUSUN RENCANA PELAKSANAAN PEMBELAJARAN
Authors: Soekisno R. Bambang Aryan , Zulkarnaen Rafiq 
Published: September 2021

Perencanaan pelaksanaan pembelajaran sebagai proses penting dalam mengajar matematika, dalam penyusunan perencanaan pembelajaran melibatkan beberapa komponen diantaranya pengetahuan konten matematika dan pengetahuan pedagogis. Kualitas penyusunan rencana pelaksanaan pembelajaran yang dilakukan oleh guru sangat dipengaruhi oleh kualifikasi pendidikan dan pengalaman mengajar. Tujuan penelitian ini yaitu: (a) mengetahui pengaruh kualifikasi pendidikan dan lama mengajar terhadap kemampuan guru matematika dalam menyusun Rencana Pelaksanaan Pembelajaran (RPP); dan (b) mengetahui kualitas pengetahuan guru matematika dalam merumuskan RPP. Studi kasus yang digunakan dalam penelitian ini yaitu kasus tunggal dan analisis ganda. Kasus yang diamati dalam penelitian ini yaitu kemampuan guru matematika dalam menyusun RPP ditinjau dari kualifikasi pendidikan dan lama mengajar, serta pengetahuan matematika guru dalam menyusun RPP. Subjek penelitian sebanyak 69 guru matematika di Kota Bogor Provinsi Jawa Barat. Kualifikasi pendidikan dibagi kedalam tiga kriteria, yaitu: Sarjana Pendidikan Matematika, Sarjana non-Pendidikan Matematika, dan Sarjana non-Pendidikan. Selain kualifikasi pendidikan, ditinjau juga dari lama mengajar. Instrumen yang digunakan dalam penelitian ini terdiri dari instrumen tes dan non tes. Instrumen tes berbentuk penyusunan RPP oleh SP pada KD 3.3 dan 4.3 pada materi SPLDV, sedangkan instrumen non tes berbentuk wawancara dan observasi. Simpulan yang diperoleh dari penelitian ini adalah kemampuan menyusun RPP tidak dipengaruhi oleh lama mengajar, namun sangat dipengaruhi oleh kualifikasi pendidikan, dan kualifikasi pendidikan memberikan dampak secara signifikan tehadap pengetahuan guru matematika.Kata kunci: Aktivitas matematis, antisipasi pedagogis-didaktis, pengetahuan konten matematika, pengetahuan pedagogis, RPP
Perspectivas y retos regionales en Terapia Ocupacional: una mirada desde la representación de Colombia en la Confederación Latinoamericana de Terapeutas Ocupacionales – CLATO
Authors: Agudelo Orozco Alexander , Zúñiga Bolívar Sandra Marcela , Cristancho González Livet Rocío 
Published: September 2021

La Confederación Latinoamericana de Terapeutas Ocupacionales (CLATO) es una organización civil, sin fines de lucro, creada en 1997. Colombia es uno de sus miembros fundadores. El propósito de la CLATO es desarrollar la profesión en la región, fortalecer la identidad y ampliar los campos de acción y cooperación internacional entre las asociaciones, instituciones y organizaciones de estudiantes y profesionales de los países participantes, a través del intercambio de opiniones y acciones gremiales, académicas, científicas y sociales. La situación actual desencadenada por la pandemia y otras realidades plantean retos en diferentes aspectos, algunos de los cuales han sido objeto de reflexiones y acciones al interior de la CLATO y se esbozan en esta editorial.
A Pilot Study to Estimate the Impact of High Matrix Image Reconstruction on Chest Computed Tomography
Authors: Inoue Akitoshi , Johnson Tucker F. , Voss Benjamin A. , Lee Yong S. , Leng Shuai , Koo Chi Wan , McCollough Brian D. , Weaver Jayse M. , Gong Hao , Carter Rickey E. , McCollough Cynthia H. , Fletcher Joel G. 
Published: September 2021

Objectives:
The objectives of the study were to estimate the impact of high matrix image reconstruction on chest computed tomography (CT) compared to standard image reconstruction.

Material and Methods:
This retrospective study included patients with interstitial or parenchymal lung disease, airway disease, and pulmonary nodules who underwent chest CT. Chest CT images were reconstructed using high matrix (1024 × 1024) or standard matrix (512 × 512), with all other parameters matched. Two radiologists, blinded to reconstruction technique, independently examined each lung, viewing image sets side by side and rating the conspicuity of imaging findings using a 5-point relative conspicuity scale. The presence of pulmonary nodules and confidence in classification of internal attenuation was also graded. Overall image quality and subjective noise/artifacts were assessed.

Results:
Thirty-four patients with 68 lungs were evaluated. Relative conspicuity scores were significantly higher using high matrix image reconstruction for all imaging findings indicative of idiopathic lung fibrosis (peripheral airway visualization, interlobular septal thickening, intralobular reticular opacity, and end-stage fibrotic change; P ≤ 0.001) along with emphysema, mosaic attenuation, and fourth order bronchi for both readers (P ≤ 0.001). High matrix reconstruction did not improve confidence in the presence or classification of internal nodule attenuation for either reader. Overall image quality was increased but not subjective noise/artifacts with high matrix image reconstruction for both readers (P < 0.001).

Conclusion:
High matrix image reconstruction significantly improves the conspicuity of imaging findings reflecting interstitial lung disease and may be useful for diagnosis or treatment response assessment.
Isolated late intradural cauda equina metastasis of renal cell carcinoma
Authors: Ali Sundus , Qasim Adnan , Salah Rahmatullah , Sarwar Muhammad Rizwan , Usman Muhammad , Shams Shahzad 
Published: September 2021

Background:
The cauda equina (CE) is the most common site for intradural extramedullary metastasis from systemic malignancies such as lung, breast, and thyroid carcinomas. However, renal cell carcinomas (RCC), with their high metastatic potential, are rarely responsible for CE metastatic lesions. Here, we report an intradural cauda equina mass, as the first and only site of metastasis of a renal cell carcinoma.

Case Description:
A 55-year-old female had undergone a left nephrectomy for renal cell carcinoma 8 years ago. She now presented with a unifocal renal cell metastasis to the CE. As such metastases are rare, establishing the correct pathological diagnosis proved to be a challenge.

Conclusion:
The cauda equina was the first and only site of an 8-year-delayed metastasis attributed to a renal cell carcinoma.
A rare case of Streptococcus anginosus infectious intracranial aneurysm: Proper management of a poor prognosis
Authors: Avallone Stephen V. , Levy Adam S. , Starke Robert M. 
Published: September 2021

Background:
Infectious intracranial aneurysms (IIAs), sometimes referred to as cerebral mycotic aneurysms, are an uncommon but feared compilation of bacterial endocarditis, occurring in up to 5% of all bacterial endocarditis cases. While IIAs carry a low risk of rupture, a ruptured mycotic aneurysm carries devastating neurologic consequences with up to an 80% mortality rate secondary to subarachnoid and intracerebral hemorrhage.

Case Description:
A 69-year-old man undergoing antibacterial therapy for Streptococcus anginosus endocarditis with aortic insufficiency and root abscess presented to the ED with multiple seizures and left-sided weakness. MRI of the head revealed right frontal and temporal abscesses with evidence of scattered septic emboli and subarachnoid hemorrhage. CTA of the head revealed a ruptured 1 mm distal middle cerebral artery mycotic aneurysm. Prior to undergoing surgery, the patient began to decline, becoming lethargic, and failing to respond to commands. The patient underwent endovascular Onyx embolization. After the procedure, the patient remained with partial status epilepticus and was discharged to rehabilitation. Over the following months, the patient made a great recovery and was able to undergo aortic and mitral valve replacement 5 months after neurosurgical intervention.

Conclusion:
This favorable outcome is the result of a tremendous deal of long-term coordination and efficient communication between neurosurgery, cardiology, neurology, physical medicine and rehabilitation, and primary care.
A survey study examining the motivations, concerns, and perspectives of medical students engaging in neurosurgical research
Authors: Barrios-Anderson Adriel , Wu Esther , Liu David D. , Snead Jameson , Lee David J. , Robbins James , Aguirre Jesus , Tang Oliver , Garcia Catherine M. , Pucci Francesco , Anderson Matthew N. , Syed Sohail , Shaaya Elias , Gokaslan Ziya L. 
Published: September 2021

Background:
In a competitive landscape for neurosurgical residency admission, research productivity is increasingly important. Medical school applicants to neurosurgery report high numbers of “scholarly products” as published by the National Residency Match Program. Despite increased student involvement in research and productivity, to the best of our knowledge, no previous reported studies have examined student perspectives on their involvement in neurosurgical research.

Methods:
For 2 consecutive years (February 2019 and February 2020), medical students (n = 55) from around the United States presented original research at the Student Neurosurgical Research Conference. Participants were administered a mixed-method survey designed to assess experiences and perspectives on engaging in neurosurgical research. Survey responses were analyzed independently by two researchers to assess for common themes and perspectives.

Results:
Medical students engaged in all types of research work across nearly every neurosurgical subfield with “Basic/Bench Lab work” (38.5%) and “Chart Review” (23.1%) representing the majority of projects. Students commonly cited “curiosity/interest,” and “residency application competitiveness” as main reasons for participation in research. About 66% of respondents reported experiencing anxiety/concern about research productivity “often” or “very often.” Thematic analysis revealed that sources of research-related stress were (1) having enough publications to match into residency, and (2) having enough time in medical school to engage in research.

Conclusion:
Medical students engaging in neurosurgical research are highly motivated students driven by scientific curiosity and pressure to prepare for competitive residency applications. Students experience anxiety due to time constraints in medical curricula and increasing demands for scholarly productivity.
Carotid–carotid crossover bypass after mechanical thrombectomy for internal carotid artery occlusion due to plaque from stenosed innominate artery
Authors: Murakami Tomoaki , Toyota Shingo , Suematsu Takuya , Wada Yuki , Shimizu Takeshi , Taki Takuyu 
Published: September 2021

Background:
The treatment for internal carotid artery occlusion (ICAO) due to innominate artery stenosis is not well established. We herein describe a case of carotid–carotid crossover bypass and common carotid artery (CCA) ligation after mechanical thrombectomy for ICAO due to a plaque from the stenosed innominate artery.

Case Description:
A 70-year-old man was transferred to our hospital because of left-sided hemiparalysis. Head magnetic resonance imaging/angiography showed a cerebral infarction in the right middle cerebral artery area and the right ICAO due to a plaque from the stenosed innominate artery. Immediately, we performed mechanical thrombectomy and successfully attained partial revascularization (Thrombolysis in Cerebral Infarction Grade 2B). After a conference with cardiovascular group, we performed carotid–carotid crossover bypass and the right CCA ligation. The treatment was successful, and no complications occurred.

Conclusion:
Carotid–carotid crossover bypass and CCA ligation may be a better option for innominate artery stenosis in selected patients.