bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemadsorption as rescue therapy for patients with multisystem organ failure in pediatric intensive care—Report of two cases reports and review of the literature
Authors: Steurer Lisa‐Maria , Schlager Gerald , Sadeghi Kambis , Golej Johann , Wiedemann Dominik , Hermon Michael 
Published: July 2021

AbstractHemadsorption via the cytokine‐adsorber CytoSorb (CytoSorbents Europe, Berlin, Germany) has successfully been used as an adjunctive method in adults, mainly for the purpose of immunomodulation under acute inflammatory conditions such as sepsis and cardiac surgery. In recent years, there has been growing interest in its use in pediatric intensive care to improve outcomes in patients with multiple organ failure following an inflammatory illness. Literature on the application of CytoSorb in neonatal and pediatric patients is scarce, though the implication is that it could be an effective last‐resort treatment option in critically ill pediatric patients. Herein we present the clinical cases of two pediatric patients successfully treated with a combination of the CytoSorb hemadsorber, continuous renal replacement therapy, and extracorporeal membrane oxygenation due to multiple organ failure following different underlying medical conditions. Patient 1 was a 7‐month‐old male child with Down's syndrome admitted to the Pediatric Intensive Care Unit (PICU) after congenital heart surgery, who developed antimicrobial‐resistant septic shock and severe acute respiratory distress syndrome. Patient 2 was a 2‐year‐old male child admitted to the PICU with influenza A‐associated acute liver failure resulting in hyperammonemia, lactate acidosis, hemodynamic instability, and acute kidney failure. In both patients, hemadsorption with CytoSorb was initiated as an adjunctive rescue therapy to treat refractory multisystem organ failure. Improvement of laboratory and clinical parameters was observed within hours of treatment initiation. The application of the hemadsorber—developed for use in adults—proved simple and safe for use in both of our low‐weight pediatric patients.
Letter: assessment of histological disease activity in Crohn's disease clinical trials—a step in the right direction, but further optimisation needed
Authors: Tsoi Andrew H. , Murugasu Anand , Garg Mayur 
Published: July 2021

LINKED CONTENTThis article is linked to Almradi et al paper. To view this article, visit https://doi.org/10.1111/apt.16248
Letter: tofacitinib in biologic‐experienced ulcerative colitis—a single‐centre real‐world experience in Australia
Authors: Lo S. W. , Connell W. , Kamm M. A. , Lust M. , Wright E. K. 
Published: July 2021

LINKED CONTENTThis article is linked to Biemans et al papers. To view these articles, visit https://doi.org/10.1111/apt.15689 and https://doi.org/10.1111/apt.16505
Editorial: assessment of inflammatory bowel disease—a picture is worth a thousand words
Authors: Horjus‐Talabur Horje Carmen S. , van Bodegraven Ad A. 
Published: July 2021

LINKED CONTENTThis article is linked to Friedman et al and Friedman & Gibson papers. To view these articles, visit https://doi.org/10.1111/apt.16452 and https://doi.org/10.1111/apt.16522
Letter: predictive factors for treatment discontinuation in IBD—anti‐TNF trough levels and anti‐drug antibodies
Authors: Demarzo Maria Giulia , Bodini Giorgia , Giuliana Elisabetta , Zentilin Patrizia , Giannini Edoardo G. 
Published: July 2021

LINKED CONTENTThis article is linked to Tournier et al and Roblin et al papers. To view these articles, visit https://doi.org/10.1111/apt.16333 and https://doi.org/10.1111/apt.16501
Letter: predictive model for gastric cancer after eradication of Helicobacter pylori—a survival analysis using a deep learning algorithm. Authors' reply
Authors: Lui Thomas K. L. , Leung Wai K. 
Published: July 2021

LINKED CONTENTThis article is linked to Leung et al and Arai et al papers. To view these articles, visit https://doi.org/10.1111/apt.16272 and https://doi.org/10.1111/apt.16492
Letter: predicting treatment discontinuation in inflammatory bowel disease—anti‐TNF trough levels and anti‐drug antibodies. Authors’ reply
Authors: Roblin Xavier , Nancey Stephane , Paul Stéphane 
Published: July 2021

LINKED CONTENTThis article is linked to Tournier et al and Demarzo et al papers. To view these articles, visit https://doi.org/10.1111/apt.16333 and https://doi.org/10.1111/apt.16494
Editorial: an elastography‐based two‐step approach to detect NAFLD with compensated advanced chronic liver disease
Authors: Wong Yu Jun 
Published: July 2021

LINKED CONTENTThis article is linked to Zhou et al and Zhou & Zheng papers. To view these articles, visit https://doi.org/10.1111/apt.16487 and https://doi.org/10.1111/apt.16528
Editorial: non‐erosive reflux disease (NERD) is often not GERD—time to change the definition or abandon the term? Authors' reply
Authors: Kim Seung Han , Park Soo Heon 
Published: July 2021

LINKED CONTENTThis article is linked to Kim et al and Katz papers. To view these articles, visit https://doi.org/10.1111/apt.16477 and https://doi.org/10.1111/apt.16480
Editorial: trends in alcohol use and alcohol‐associated liver disease in the US population—authors' reply
Authors: Singal Ashwani K. , Arsalan Arshad , Dunn Winston , Arab Juan P. , Wong Robert J. , Kuo Yong‐Fang , Kamath Patrick S. , Shah Vijay H. 
Published: July 2021

LINKED CONTENTThis article is linked to Singal et al and Barnard & Dave papers. To view these articles, visit https://doi.org/10.1111/apt.16461 and https://doi.org/10.1111/apt.16491
Editorial: assessment of inflammatory bowel disease: a picture is worth a thousand words. Authors' reply
Authors: Friedman Antony B. , Gibson Peter R. 
Published: July 2021

LINKED CONTENTThis article is linked to Friedman et al and Horjus‐Talabur Horje & van Bodegraven papers. To view these articles, visit https://doi.org/10.1111/apt.16452 and https://doi.org/10.1111/apt.16476
Editorial: natural history of hepatitis delta virus‐induced liver disease ‐ less severe today but still needs attention
Authors: Gençdal Genco , Zeybel Müjdat , Yurdaydin Cihan 
Published: July 2021

LINKED CONTENTThis article is linked to Palom et al paper. To view this article, visit https://doi.org/10.1111/apt.16485
Editorial: inconclusive diagnosis of GERD: are new parameters in impedance‐pHmetry ready for clinical use? Authors' reply
Authors: Ribolsi Mentore , Frazzoni Marzio , Marabotto Elisa , Cicala Michele , Savarino Edoardo 
Published: July 2021

LINKED CONTENTThis article is linked to Ribolsi et al and Sergeev & Sifrim papers. To view these articles, visithttps://doi.org/10.1111/apt.16481andhttps://doi.org/10.1111/apt.16509
A systematic review of literature regarding food insecurity in Sweden
Authors: Rost Stephanie , Lundälv Jörgen 
Published: July 2021

AbstractFood insecurity is not a term that is traditionally utilized in relation to Sweden, which has a well‐established welfare state. In fact, the discussion around this issue appears to be predicated on the notion that it is a concept existing outside the country. However, European countries are in no way immune to the issue of food insecurity. The Food and Agricultural Organisation to the United Nations holds data on the levels of food insecurity gathered from the Gallup poll and this indicated increasing levels of moderate‐to‐severe insecurity among the population. This indicated a need to review the research and literature on food insecurity in Sweden. This was carried out using two of the largest databases SCOPUS and Public/Publisher MEDLINE (PubMed) as well as a search for gray data using Google Scholar. Following backward and forward searches, in total only five articles were deemed relevant for inclusion. These were discussed and show very limited analysis of the issue, with their connection to food insecurity in Sweden being either abstract or unfocussed on the issue directly. This demonstrates a fundamental gap in this area of research and leaves open questions as to why this is the case.
Changing channels? A comparison of Fox and MSNBC in 2012, 2016, and 2020
Authors: Lanning Kevin , Wetherell Geoffrey , Warfel Evan A. , Boyd Ryan L. 
Published: July 2021

AbstractWe compare the contents of Fox and MSNBC weekday evening telecasts using natural language analysis with Linguistic Inventory Word Count (LIWC) and sociopolitical dictionaries tapping into moral foundations, values, grievances, and personality. Across time, the two networks differed substantially across many constructs, particularly those from LIWC. The core of the difference between the networks was captured by a four‐component measure which we labeled Personalizing versus Formal speech. Scores on this measure were particularly volatile during 2019 and 2020, a period which included Trump's first impeachment, the beginning of the COVID pandemic, and the 2020 presidential campaign. In comparison with prior presidential election years, only MSNBC showed a drop in positive emotions in 2020, while both networks increased in the use of communal and analytic language. Contrary to our expectations, the language style of the two networks did not demonstrate increasing divergence over time.
Managing the Humanitarian Workplace: Capitalist Social Time and Iraqi Refugees in the United States
Authors: Sheldon Zachary 
Published: July 2021

AbstractThis paper offers an ethnographic account of tensions around time that arose at a small nonprofit offering employment‐assistance programs for newly arrived Iraqi refugees in a large American city. Iraqi refugees have been subjected to multiple interventions, each of which put them on a strict timeline for results. Their experience gives rise to critical insights into the abstract, managerial representations of time that coordinate each of these successive programs. Staff responded to these concerns by attempting to correct clients’ expectations about the future, but this effort remained bound to the same temporal standard and therefore produced further frustrations on the part of clients. Meanwhile, the one employee who attempted to implement an alternative project ended up being disciplined by her employer for misusing time on the job. Tracing this dynamic of tension, conflict, and reconfiguration across multiple standpoints, the paper demonstrates how humanitarian work unfolds through the same contradictions between abstract and concrete forms of time that characterizes commodity‐directed labor under the capitalist mode of production as a whole. This finding complicates theoretical models of political subjectivity that have hitherto informed anthropological critiques of humanitarianism and points to abstract social time as a specifically capitalist mechanism of power at work.
The Hygienic Problem of Social Innovation Work: Reversibility and Oscillations between “the Social” and “the Economic”
Authors: Mikkelsen Nanna Søvsø , Vangkilde Kasper Tang 
Published: July 2021

AbstractIn recent years, social innovation has received attention as a promising solution to societal challenges, not least because of its claims to create a symbiosis between social purposes and economic benefits. The often uneasy relation between social values and economic values is, however, not easily resolved in practice. Based on ethnographic research in the field of social innovation in Denmark, we argue that the relation between “the social” and “the economic,” representing different value logics, is essentially one of reversibility. The two each encompass their apparent opposite within themselves. This reversible relation elicits a number of challenging oscillations when social innovation is enacted in practice. We term this the hygienic problem of social innovation work. Too much or too little of either the social or the economic contaminates and obfuscates the endeavor of social innovation. As a result, people who do social innovation work seek to enact the “right” or “pure” relation between social and economic concerns. We suggest, however, that the potential of social innovation lies not in this search for purity. Rather, the instability of these categories prompts a continual exploration and creative rethinking of how the intersection of society and business may unfold.
Determinants for under‐ and overdosing of direct oral anticoagulants and physicians' implementation of clinical pharmacists' recommendations
Authors: Moudallel Souad , Cornu Pieter , Dupont Alain , Steurbaut Stephane 
Published: July 2021

AimsTo analyse the appropriateness of direct oral anticoagulant (DOAC) dosing and determinants for under‐and overdosing as well as acceptance and implementation rates of pharmacists' interventions.MethodsCross‐sectional study in a tertiary hospital in hospitalized patients with atrial fibrillation on DOACs in 2019 (n = 1688). Primary outcome was the proportion of patients with inappropriate DOAC prescribing with identification of determinants for under‐and overdosing. Secondary outcomes included acceptance and implementation rates of pharmacists' recommendations and determination of reasons for nonacceptance/nonimplementation.ResultsInappropriate prescribing was observed in 16.9% of patients (n = 286) with underdosing (9.7%) being more prevalent than overdosing (6.9%). For all DOACs considered together, body weight<60 kg (odds ratio [OR] 0.46 [0.27–0.77]), edoxaban use (OR 0.42 [0.24–0.74]), undergoing surgery (OR 0.57 [0.37–0.87]) and being DOAC naïve (OR 0.45 [0.29–0.71]) were associated with significantly lower odds of underdosing. Bleeding history (OR 1.86 [1.24–2.80]) and narcotic use (OR 1.67 [1.13–2.46]) were associated with significantly higher odds for underdosing. Determinants with a significantly higher odds of overdosing were renal impairment (OR 11.29 [6.23–20.45]) and body weight<60 kg (OR 2.34 [1.42–3.85]), whereas dabigatran use (OR 0.24 [0.08–0.71]) and apixaban (OR 0.18 [0.10–0.32]) were associated with a significantly lower odds of overdosing compared to rivaroxaban. Physicians accepted the pharmacists' advice in 179 cases (79.2%) consisting of 92 (51.4%) recommendations for underdosing, 82 (45.8%) for overdosing and 5 (2.8%) for contraindications.ConclusionInappropriate DOAC prescribing remains common, although there is a slight improvement compared to our study of 2016. Clinical services led by pharmacists help physicians to reduce the number of inadequate prescriptions for high‐risk medications such as DOACs.
Review on marine sponge alkaloid, aaptamine: A potential antibacterial and anticancer drug
Authors: Nadar Vinita Manimaran , Manivannan Selvambigai , Chinnaiyan Rajasekar , Govarthanan Muthusamy , Ponnuchamy Kumar 
Published: July 2021

AbstractIn recent years, biological macromolecules have piqued the interest of researchers owing to their vast variety of biological uses. As a result, the marine sponge is a multicellular heterotrophic parazoan with chemicals for defence against predator assaults, biofouling and microbial diseases. These priceless molecules are known as secondary metabolites, and they are essential for survival in a highly competitive environment. So far, over 5,000 marine natural compounds have been extracted from marine sponges, making them an excellent option for drug formulation. One among them is, aaptamine, a marine alkaloid with a benzo[de][1,6]‐napthyridine framework extensively distributed in marine sponges. Due to this reason, aaptamine has been intensively researched for various biological purposes, including cancer and protease inhibition, offering fresh insights into novel treatments. Keeping this in mind, we reviewed the biological significance of the marine sponge alkaloid aaptamine.
Strengths and difficulties in children with specific learning disabilities
Authors: Ayar Ganime , Yalçın Sıddıka Songül , Tanıdır Artan Özge , Güneş Hasan Tahsin , Çöp Esra 
Published: July 2021

AbstractBackgroundThe study aims to investigate the social, emotional, and behavioral challenges in children with a specific learning disability (SLD) and to identify the factors that accompany these problems by screening with the Strengths and Difficulties Questionnaire (SDQ).MethodsThe descriptive study was conducted on 278 children with SLD. Strengths and difficulties in children were evaluated by the SDQ applied to their mothers. The percentage of cases above the cut‐off limits of the SDQ was calculated. Chi‐square test and multiple logistic regression analysis were used for analysis.ResultsThe mean (SD) total SDQ score was 15.8 (6.5). The percentage of scores of abnormal total difficulties in SLD was 47.8%. Multivariate analysis revealed that cases exposed to antenatal smoking had higher odds ratio of abnormal emotional symptoms and abnormal total difficulties; cases with poor familial income and the presence of a history of antenatal smoking exposure showed considerably higher odds ratio of conduct problems; cases with younger age at the diagnosis of SLD, dyscalculia, extreme duration of preschool screen time (≥4 h), and history of hospitalization had significantly higher odds ratio for hyperactivity–inattention problems; and cases having shorter breastfeeding duration had higher odds ratio of peer problems compared to counterparts.ConclusionChildren with SLD have a high score on the SDQ. Practitioners could especially give guidance and support to families with financial problems and those having a child with an early age at diagnosis, exposure to antenatal smoking, short breastfeeding period, early age of the first screen use, and long screen exposure duration during the preschool period.
Prevalence of fatigue and associated factors among clinically stable patients with chronic obstructive pulmonary disease in Guizhou, China: A cross‐sectional study
Authors: Wang LianHong , Guo Yunmei , Liu Ying , Yan Xin , Ding Rui , Huang Shiming 
Published: July 2021

AbstractIntroductionFatigue is important, but ignored symptom among COPD patients. At present, there is very limited data are available for the prevalence of fatigue and its risk factors among COPD patients in China.ObjectiveThe purpose of this study is to determine the prevalence of fatigue and to investigate the factors associated with fatigue among clinically stable patients with COPD in China.MethodsThis is a cross‐sectional study using a questionnaire to collect data on sociodemographic, related to COPD disease, and exercise habits. Multidimensional fatigue inventory (MFI‐20) was used to assess the prevalence of fatigue. Independent samples t test, bivariate correlation, one‐way ANOVA test, and test for several independent samples were used to compare the sociodemographic factors with MFI‐20 scores of COPD patients. Multiple stepwise linear regression was performed to estimate influencing factors related to the MFI‐20 of COPD patients.ResultsAmong the participants, the prevalence of fatigue was 88.62%. Negative correlations were found between FEV1% and multidimensional fatigue (r = −0.40, p < 0.01), general fatigue (r = −0.20, p < 0.05), reduced activity (r = −0.20, p < 0.01), and physical fatigue (r = −0.10, p < 0.01). A multiple linear regression models revealed that age (p < 0.05), BMI (p < 0.05), FEV1% (p < 0.01), exercise times (p < 0.01), and the times of hospitalization in the past 12 months (p < 0.05) were associated with multidimensional fatigue scores.ConclusionsThe prevalence of fatigue is high among clinically stable patients with COPD. Keeping exercise, prevention obesity, and exacerbation should be an effective intervention strategy to reduce COPD‐related fatigue.
Are we managing our patients correctly following treatment for cervical glandular intraepithelial neoplasia? A review of practice at the Jessop Wing Colposcopy Unit
Authors: Magro Abigail , Lyon Rachel , Ellis Kay M. , Tidy John A. , Macdonald Madeleine C. , Palmer Julia E. 
Published: July 2021

AbstractObjectiveWomen diagnosed with cervical glandular intraepithelial neoplasia (CGIN) remain at risk of further pre‐malignant and malignant disease and require rigorous post‐treatment follow‐up. We assess the effectiveness and safety of community cervical sampling follow‐up in women treated for CGIN.MethodsA retrospective study was conducted of women diagnosed with CGIN between April 1, 2013, and March 31, 2019, at Jessop Wing Colposcopy Unit, Sheffield, UK.ResultsOf 140 women diagnosed with CGIN, 76 had co‐existing cervical intraepithelial neoplasia (CIN). Cytologists were significantly more likely to report glandular neoplasia in the absence of co‐existing CIN, and high‐grade dyskaryosis in its presence (Ps < 0.0001). Co‐existing CIN was significantly more likely to be present with high or low‐grade compared to normal colposcopy findings (P < 0.0001). The 6‐month test of cure (TOC) was attended by 67% of women (84% within 12 months), and the 18‐month post‐treatment sampling by 52.5% of women (70% within 24 months). Colposcopy recalled 96% of women correctly for the 18‐month sampling, but 20% of women undertaking primary care samples were incorrectly recalled at 3 years instead.ConclusionsWhen CGIN is diagnosed, two dates for recall should be provided at 6 and 18 months post‐treatment to the Cervical Screening Administration Service and the centralised screening laboratory ensuring the 18‐month post‐treatment sample is correctly appointed, preventing women with HPV‐negative TOC samples being returned to 3‐year recall. Follow‐up of CGIN should be closely audited by the centralised laboratories ensuring women with CGIN are not put at additional risk.
Validation of the Orlando Protocol for endoscopic management of pancreatic fluid collections in the era of lumen‐apposing metal stents
Authors: Bang Ji Young , Wilcox C. Mel , Arnoletti Juan Pablo , Peter Shajan , Christein John , Navaneethan Udayakumar , Hawes Robert , Varadarajulu Shyam 
Published: July 2021

ObjectivesAlthough lumen‐apposing metal stents (LAMS) are being increasingly used in lieu of plastic stents, the clinical approach to endoscopic management of pancreatic fluid collections (PFCs) is poorly standardized. We compared outcomes of approaches over two time intervals, initially using plastic stents and later integrating LAMS.MethodsThis was a retrospective, observational, before–after study of prospectively collected data on consecutive patients with symptomatic PFCs managed over two time periods. In the initial period (January 2010–January 2015) endoscopic treatment was undertaken with plastic stents and in the later period (February 2015–August 2020) by integration of LAMS with selective use of plastic stents. The treatment strategy in both periods were tailored to size, extent, type of PFC and stepwise response to intervention. The main outcome was treatment success, defined as resolution of PFC and presenting symptoms at 6‐month follow‐up.ResultsA total of 160 patients were treated with plastic stents and 227 patients were treated using an integrated LAMS approach. Treatment success was significantly higher for the integrated approach compared to using only plastic stents (95.6 vs. 89.4%; P = 0.018), which was confirmed to be predictive of treatment success on multivariable logistic regression analysis (odds ratio 2.7, 95% confidence interval 1.1–6.4; P = 0.028).ConclusionsA structured approach integrating LAMS with selective use of plastic stents improved treatment success in patients with PFCs compared to an approach using only plastic stents.