bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of New miRNA-mRNA Networks in the Development of Non-syndromic Cleft Lip With or Without Cleft Palate
Authors: Fu Chengyi , Lou Shu , Zhu Guirong , Fan Liwen , Yu Xin , Zhu Weihao , Ma Lan , Wang Lin , Pan Yongchu 
Published: March 2021

Objective: To identify new microRNA (miRNA)-mRNA networks in non-syndromic cleft lip with or without cleft palate (NSCL/P).Materials and Methods: Overlapping differentially expressed miRNAs (DEMs) were selected from cleft palate patients (GSE47939) and murine embryonic orofacial tissues (GSE20880). Next, the target genes of DEMs were predicted by Targetscan, miRDB, and FUNRICH, and further filtered through differentially expressed genes (DEGs) from NSCL/P patients and controls (GSE42589), MGI, MalaCards, and DECIPHER databases. The results were then confirmed by in vitro experiments. NSCL/P lip tissues were obtained to explore the expression of miRNAs and their target genes.Results: Let-7c-5p and miR-193a-3p were identified as DEMs, and their overexpression inhibited cell proliferation and promoted cell apoptosis. PIGA and TGFB2 were confirmed as targets of let-7c-5p and miR-193a-3p, respectively, and were involved in craniofacial development in mice. Negative correlation between miRNA and mRNA expression was detected in the NSCL/P lip tissues. They were also associated with the occurrence of NSCL/P based on the MGI, MalaCards, and DECIPHER databases.Conclusions: Let-7c-5p-PIGA and miR-193a-3p-TGFB2 networks may be involved in the development of NSCL/P.
Kinetics of Immunoglobulins in Septic Shock Patients Treated With an IgM- and IgA-Enriched Intravenous Preparation: An Observational Study
Authors: Berlot Giorgio , Scamperle Alice , Istrati Tatiana , Dattola Roberto , Longo Irene , Chillemi Antonino , Baronio Silvia , Quarantotto Giada , Zanchi Silvia , Roman-Pognuz Erik , Bixio Mattia , Tomasini Ariella 
Published: March 2021

Objective: To assess the variations of the blood levels of immunoglobulins (Ig) in septic shock patients treated with an Ig preparation enriched in IgM and IgA (eIg).Design: The blood levels of Ig in survivors (S) and non-survivors (NS) of a group of septic shock patients were measured before the initial administration (D0) and 1 (D1), 4 (D4), and 7 (D7) days thereafter. The SAPS II score, the capillary permeability, the primary site of infection, the antibiotic appropriateness, and the outcome at 28 days were also assessed.Results: In the interval D0–D7, the IgM increased significantly only in the S while remained stable in NS; the IgA significantly increased in both groups; the IgG did not vary significantly in both groups. At D4, the capillary permeability significantly decreased in S but not in NS.Conclusions: The kinetics of the different classes of Ig after eIg were different between S and NS. This could be related either to (a) different capillary permeability in the two groups or to (b) higher Ig consumption in NS. Further studies to confirm the benefits of eIg in the treatment of sepsis syndrome and to define the specific target population and the correct eIg dose are warranted.
Consistency and Stability of Motor Subtype Classifications in Patients With de novo Parkinson’s Disease
Authors: Ren Jingru , Pan Chenxi , Li Yuqian , Li Lanting , Hua Ping , Xu Ligang , Zhang Li , Zhang Wenbin , Xu Pingyi , Liu Weiguo 
Published: March 2021

ObjectivePatients with Parkinson’s disease (PD) are commonly classified into subtypes based on motor symptoms. The aims of the present study were to determine the consistency between PD motor subtypes, to assess the stability of PD motor subtypes over time, and to explore the variables influencing PD motor subtype stability.MethodsThis study was part of a longitudinal study of de novo PD patients at a single center. Based on three different motor subtype classification systems proposed by Jankovic, Schiess, and Kang, patients were respectively categorized as tremor-dominant/indeterminate/postural instability and gait difficulty (TD/indeterminate/PIGD), TDS/mixedS/akinetic-rigidS (ARS), or TDK/mixedK/ARK at baseline evaluation and then re-assessed 1 month later. Demographic and clinical characteristics were recorded at each evaluation. The consistency between subtypes at baseline evaluation was assessed using Cohen’s kappa coefficient (κ). Additional variables were compared between PD subtype groups using the two-sample t-test, Mann–Whitney U-test or Chi-squared test.ResultsOf 283 newly diagnosed, untreated PD patients, 79 were followed up at 1 month. There was fair agreement between the Jankovic, Schiess, and Kang classification systems (κS = 0.383 ± 0.044, κK = 0.360 ± 0.042, κSK = 0.368 ± 0.038). Among the three classification systems, the Schiess classification was the most stable and the Jankovic classification was the most unstable. The non-motor symptoms questionnaire (NMSQuest) scores differed significantly between PD patients with stable and unstable subtypes based on the Jankovic classification (p = 0.008), and patients with a consistent subtype had more severe NMSQuest scores than patients with an inconsistent subtype.ConclusionFair consistency was observed between the Jankovic, Schiess, and Kang classification systems. For the first time, non-motor symptoms (NMSs) scores were found to influence the stability of the TD/indeterminate/PIGD classification. Our findings support combining NMSs with motor symptoms to increase the effectiveness of PD subtypes.
A Journey From SARS-CoV-2 to COVID-19 and Beyond: A Comprehensive Insight of Epidemiology, Diagnosis, Pathogenesis, and Overview of the Progress into Its Therapeutic Management
Authors: Shoaib Muhammad Harris , Ahmed Farrukh Rafiq , Sikandar Muhammad , Yousuf Rabia Ismail , Saleem Muhammad Talha 
Published: March 2021

The 2019 novel coronavirus (2019-nCoV), commonly known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19), was first revealed in late 2019 in Wuhan city, Hubei province, China. It was subsequently spread globally and thereby declared as a pandemic by WHO in March 2020. The disease causes severe acute respiratory illness and is highly contagious due to the fast-onward transmission. As of the mid of November 2020, the disease has affected 220 countries with more than 16 million active cases and 1.3 million deaths worldwide. Males, pregnant women, the elderly, immunosuppressed patients, and those with underlying medical conditions are more vulnerable to the disease than the general healthy population. Unfortunately, no definite treatment is available. Although remdesivir as an antiviral had been approved for use in those above 12 years of age and 40 kg weight group, it has been observed to be ineffective in large-scale SOLIDARITY trials by WHO. Moreover, dexamethasone has been found to increase the recovery rate of ventilated patients; oxygen and inhaled nitric oxide as a vasodilator have been given emergency expanded access. In addition, more than 57 clinical trials are being conducted for the development of the vaccines on various platforms. Two vaccines were found to be significantly promising in phase III results. It is concluded that till the approval of a specific treatment or development of a vaccine against this deadly disease, the preventive measures should be followed strictly to reduce the spread of the disease.
Cost-Effectiveness Analysis of Adding Daratumumab to Bortezomib, Melphalan, and Prednisone for Untreated Multiple Myeloma
Authors: Cao Yaohua , Zhao Lina , Zhang Tiantian , Cao Weiling 
Published: March 2021

Background: To evaluate the cost-effectiveness of adding daratumumab to bortezomib, melphalan, and prednisone for transplant-ineligible newly diagnosed multiple myeloma patients.Methods: A three-state Markov model was developed from the perspective of US payers to simulate the disease development of patient’s life time for daratumumab plus bortezomib, melphalan, and prednisone (D-VMP) and bortezomib, melphalan, and prednisone (VMP) regimens. The primary outputs were total costs, expected life-years (LYs), quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICERs).Results: The base case results showed that adding daratumumab to VMP provided an additional 3.00 Lys or 2.03 QALYs, at a cost of $262,526 per LY or $388,364 per QALY. Sensitivity analysis indicated that the results were most sensitive to utility of progression disease of D-VMP regimens, but no matter how these parameters changed, ICERs remained higher than $150,000 per QALY.Conclusion: In the case that the upper limit of willingness to pay threshold was $150,000 per QALY from the perspective of US payers, D-VMP was not a cost-effective regimen compared to VMP.
An Assessment of Impact of Leadership Training on Health System Performance in Selected Counties in Kenya
Authors: Chelagat Tecla , Rice James , Onyango Joseph , Kokwaro Gilbert 
Published: March 2021

Introduction: The provision of health care services in Kenya was devolved from the national government to the counties in 2013. Evidence suggests that health system performance in Kenya remains poor. The main issue is poor leadership resulting in poor health system performance. However, most training in Kenya focuses on “leaders” (individual) development as opposed to “leadership” training (development of groups from an organization). The purpose of that study was to explore the impact of leadership training on health system performance in selected counties in Kenya.Methods: A quasi-experimental time-series design was employed. Pretest, posttest control-group design was utilized to find out whether the leadership development program positively contributed to the improvement of health system performance indicators compared with the non-trained managers. Questionnaires were administered to 31 trained health managers from the public, private for-profit, and private not-for-profit health institutions within the same counties.Results: The pretest and posttest means for all the six health system (HS) pillar indicators of the treatment group were higher than those of the control group. The regression method to estimate the DID structural model used to calculate the “fact” and “counterfactual” revealed that training had a positive impact on the intended outcome on the service delivery, information, leadership and governance, human resources, finance, and medical products with impact value ≥1 (57.2).Conclusion: The study findings support both hypotheses that trained health care management teams had a significant difference in the implementation status of priority projects and, hence, had a significant impact on health system performance indicators compared with non-trained managers.
EFEKTIFITAS PERLINDUNGAN PENYU LAUT DAN HABITAT PESISIR PASIE PANGA MELALUI QANUN MUKIM PANGA NOMOR 1 TAHUN 2016
Authors: Masyumi Masyumi , Nasution M. Arif , Gazali Mohamad , Zuraidah Syarifah 
Published: March 2021

Qanun kabupaten/kota adalah Peraturan Perundang-undangan sejenis peraturan daerah kabupaten/kota yang mengatur penyelenggaraan pemerintahan dan kehidupan masyarakat kabupaten/kota di Aceh. Pada tahun 2012 Pemuda yang berasal dari beberapa desa pinggiran pantai di Kecamatan Panga, mereka membentuk tim konservasi penyu yang diberi nama Tim Konservasi Penyu Aroen Meubanja. Tim konservasi bersama masyarakat bekerjasama untuk mengatasi masalah pencurian telur penyu dan kerusakan terhadap habitat penyu. Jika kegiatan tersebut tidak dihentikan maka keberlangsungan hidup penyu akan terancam punah. Masalah yang dihadapi dalam penelitian ini adalah seberapa besar tingkat efektivitas dari dan bagaimana hasil evaluasi dari penerapan Qanun Mukim Panga. Untuk mengatasi masalah tersebut maka peneliti menggunakan metode AHP untuk mengetahui efektifitas perlindungan penyu dan habitat. Data yang digunakan dalam penelitian ini adalah data hasil jawaban kuesioner yang dibagikan kepada 39 responden dengan dua jenis kuesioner, yaitu kuesioner AHP dan kuesioner analisis SWOT. Kriteria yang digunakan dalam penelitian ini adalah sosialisasi qanun, pelaksanaan qanun, perlindungan penyu, dan sanksi. Langkah- langkah untuk mengetahui tingkat efektifitas dengan metode AHP adalah dengan menyusun tingkat prioritas dari empat kriteria, menghitung matriks pembobotan, dan faktor evaluasi dan hasil pada masing-masing kriteria. berdasarkan hasil urutan langkah pada metode AHP, diketahui tingkat efektifitas dari penerapan qanun mukim panga adalah sebesar 0,87 (87%).
REALISASI PENGAJARAN BAHASA ARAB MELALUI MEDIA AUDIO VISUAL PADA MAHASISWA CLUB BAHASA ARAB IAIN PONTIANAK
Authors: Hidayat Moh Yusuf 
Published: March 2021

This research aimed to determine the form of Arabic language learning realization through audio visual media on Arabic club students in IAIN Pontianak. It focused on the Arabic learning materials and whether this activity can improve the competence of Arabic club students in learning Arabic language which is expected on KKNI Arabic language for university. This research used qualitative approach using descriptive data through interview from informants in IAIN Pontianak. The result revealed that Arabic language learning realization through audio visual media on Arabic club students carried out by mentors in IAIN Pontianak is not more than the realization of learning pattern which determine on the implementation of the Arabic lesson plan and syllabus, and than the materials taught has referred to the standard of competence expected in university on KKNI Arabic language, and teaching realization can measure the competence of Arabic club students expected in university on KKNI Arabic language.
Keywords: Arabic Language, Audio Visual Media, IAIN Pontianak
Assistência de enfermagem a pacientes portadores de insuficiência cardí­aca descompensada: uma revisão integrativa
Authors: Mendes Diniz Flávia Mariana , Cordeiro Gonçalves Karla 
Published: March 2021

O objetivo do estudo foi identificar os cuidados de enfermagem a pacientes portadores de insuficiência cardí­aca descompensada descritos em literatura nacional e internacional. Método- Foi realizada uma Revisão Integrativa. A busca foi realizada de forma sistematizada nas bases de dados LILACS, BDENF, IBECS, MEDLINE e Pubmed. Resultados- A amostra constituiu-se de oito artigos, sendo possí­vel identificar intervenções de enfermagem educativas para o controle e prevenção da doença, intervenções durante a internação e após a alta hospitalar. Conclusão- Dentre os estudos selecionados, ficou evidenciado que as intervenções de enfermagem são fundamentais para prevenção e promoção a saúde a pacientes portadores de insuficiência cardí­aca descompensada nos diversos cenários de atenção í saúde. O acompanhamento e a educação em saúde ao paciente com insuficiência cardí­aca têm grande potencial para atingir mudanças de atitudes e comportamento no enfrentamento a doença.
PENERAPAN MODEL PEMBELAJARAN THINK PAIR SHARE UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA MATA PELAJARAN BAHASA INGGRIS SISWA MTs NEGERI BINJAI
Authors: Nur Khairani Dra. Hj. 
Published: March 2021

Penelitian ini bertujuan untuk mendeskripsikan proses penerapan model pembelajaran think pair share untuk meningkatkan aktivitas siswa MTs Negeri Binjai dan mendeskripsikan hasil belajar bahasa inggris siswa sebelum dan sesudah penerapan model pembelajaran think pair share siswa MTs Negeri Binjai. Penelitian ini dilakukan dalam 2 (dua) siklus, yang terdiri dari 4 langkah yaitu perencanaan, tindakan, pengamatan dan refleksi. Tiap siklus terdiri dari 2 pertemuan, dengan indikator yang hendak dicapai yaitu kemampuan belajar siswa meningkat setelah dilakukannya sebuah tindakan. Berkaitan dengan hal tersebut, maka pada prosedur penelitian ini disajikan kegiatan pra tindakan dan kegiatan pelaksanaan tindakan. Kegiatan pelaksanaan tindakan memuat : Perencanaan tindakan, pelaksanaan tindakan, tahapan pengamatan, tahap refleksi. Rata-rata hasil belajar siswa pada tes siklus I sebesar 71,75, sedangkan rata-rata hasil belajar siswa pada tes siklus II adalah 88, dan terjadi peningkatan sebesar 16,25. Begitupun juga dengan ketuntasan belajar siswa yang mengalami peningkatan hingga 42,5%, dengan rincian ketuntasan belajar siswa pada siklus I adalah 37,5% dan ketuntasan belajar siswa pada siklus II adalah 80%. disimpulkan bahwa dengan meningkatnya aktivitas peneliti dalam menerapkan penggunaan media gambar dari siklus I ke siklus II dan kegiatan aktivitas siswa dari siklus 1 ke siklus II maka menjadikan kemampuan kosa kata Bahasa Inggris siswa mengalami peningkatan. Hal ini menunjukkan penerapan model pembelajaran Think Pair Share dapat meningkatkan kemampuan Bahasa Inggris siswa kelas kelas VIl MTs Negeri Binjai.
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE JIGSAW TERHADAP KEMAMPUAN PEMAHAMAN KONSEP MATEMATIS
Authors: Saputri Lilis 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui pengaruh kemampuan pemahaman konsep matematika siswa dengan penerapan model pembelajaran kooperatif tipe Jigsaw di kelas VII MTs Miftahul Ula Pematang Cengal. Jenis penelitian ini adalah eksperimen semu (quasi eksperimen) dengan desain Pretest-Posttest-control Group Desain. Teknik analisis data menggunakan uji Regresi Sederhana. Hasil penelituan menunjukan bahwa pembelajaram matematika mengunakan Pembelajaran Kooperatif Tipe Jigsaw berpengaruh terhadap kemampuan pemahaman konsep matematika. Hal ini ditunjukan dari hasil pengujian bahwa bahwa Fhitung> Ftabel yaitu 4,277>4,171.
PENGARUH MODEL PEMBELAJARAN SNOWBALL THROWING TERHADAP KEMAMPUAN KOMUNIKASI MATEMATIS SISWA PADA MATERI MATRIKS KELAS XI SMK NEGERI 1 STABAT TAHUN PELAJARAN 2019/2020
Authors: Siregar Evi Ramadhani , - Mardiati 
Published: March 2021

Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh signifikan model pembelajaran Snowball Throwing terhadap kemampuan komunikasi matematis siswa kelas XI SMK Negeri 1 Stabat Tahun Pelajaran 2019/2020. Populasi dalam penelitian ini adalah siswa kelas XI SMK Negeri 1 Stabat Tahun Pelajaran 2019/2020. Sedangkan dalam sampel ini terdiri dari 2 kelas. Kelas XI-1 sebagai kelas eksperimen berjumlah 32 orang siswa, pada kelas XI-2 sebagai kelas kontrol berjumlah 32 orang siswa. Kelas eksperimen pembelajaran dengan menggunakan pembelajaran Snowball Throwing dan pada kelas kontrol menggunakan pembelajaran langsung. Jenis penelitian ini adalah penelitian eksperimen dengan pretest dan posttest, sebagai alat pengumpul data digunakan tes kemampuan komunikasi matematis yang terdiri dari 5 butir soal uraian. Uji hipotesis yang digunakan adalah uji regresi linier sederhana. Berdasarkan uji hipotesis didapat Fhitung > Ftabel yaitu 4,37 > 4,16 pada uji keberatian, maka H0 ditolak dan Ha diterima sehingga arah koefisien berarti, uji kelinieritas apabila Fhitung < Ftabel yaitu 0,577 < 4,16 maka H0 ditolak dan Ha diterima maka linier, diperoleh rhitung > rtabel yaitu 103,725 > 0,3494 maka (r ≠ 0) dengan taraf signifikan 5%. Sehingga dapat diambil kesimpulan bahwa terdapat pengaruh model pembelajaran snowball throwing terhadap kemampuan komunikasi matematis siswa pada materi matriks kelas XI SMK Negeri 1 Stabat tahun pelajaran 2019/2020.
PENGARUH MODEL PEMBELAJARAN PROBLEM BASED LEARNING (PBI) TERHADAP KEMAMPUAN PEMECAHAN MASALAH MATEMATIK SISWA
Authors: Wirevenska Ice , Mardiati Mardiati , Listiana Yeni 
Published: March 2021

Tujuan penelitian ini adalah untuk mengetahui pengaruh model pembelajaran Problem Based Instruction (PBI) terhadap kemampuan pemecahan masalah matematik siswa. Penelitian ini dilaksanakan di SMP Negeri 3 Hinai. Jenis penelitian ini adalah eksperimen semu (quasi eksperimen). Pengambilan sampel dilakukan secara acak (random sampling). Sampel penelitian ini adalah 60 siswa yang terdiri atas 30 siswa kelas eksperimen dan 30 siswa kelas kontrol. Instrumen penelitian yang digunakan berupa tes yang terdiri dari 3 soal uraian. Uji prasyarat yang digunakan adalah uji Liliefors untuk menguji normalitas data sedangkan uji Fisher untuk menguji homogenitas data. Berdasarkan hasil uji normalitas diperoleh bahwa kedua populasi homogen (sama). Teknik analisis data menggunakan uji regresi linier sederhana. Berdasarkan hasil penelitian nilai rata- rata kelas eksperimen 84,58 dan nilai rata- rata kelas kontrol 74,5. Terdapat pengaruh antara pembelajaraan menggunakan Problem Based Instruction (PBI) terhadap kemampuan pemecahan masalah matematik siswa yang dapat dilihat dari hasil perhitungan uji regresi linier sederhana diperoleh rtabel = 0,361, sementara berdasarkan perhitungan yang telah dilakukan di peroleh rhitung = 0,48 Dari perhitungan terlihat bahwa rhitung > rtabel ( 0,48 > 0,361). Dengan demikian hipotesis yang di ajukan di terima, yang artinya “terdapat pengaruh antara pembelajaraan menggunakan Problem Based Instruction (PBI) terhadap kemampuan pemecahan masalah matematik siswa yang dapat dilihat dari hasil perhitungan.
Neutral Metals in the Atmosphere of HD 149026b
Authors: Ishizuka Masato , Kawahara Hajime , Nugroho Stevanus K. , Kawashima Yui , Hirano Teruyuki , Tamura Motohide 
Published: March 2021

Abstract
Recent progress in high-dispersion spectroscopy has revealed the presence of vaporized heavy metals and ions in the atmosphere of hot Jupiters whose dayside temperature is larger than 2000 K, categorized as ultrahot Jupiters (UHJs). Using the archival data of high-resolution transmission spectroscopy obtained with the Subaru telescope, we searched for neutral metals in HD 149026b, a hot Jupiter cooler than UHJs. By removing stellar and telluric absorption and using a cross-correlation technique, we report a tentative detection of neutral titanium with 4.4σ and a marginal signal of neutral iron with 2.8σ in the atmosphere. This is the first detection of neutral titanium in an exoplanetary atmosphere. In this temperature range, titanium tends to form titanium oxide (TiO). The fact that we did not detect any signal from TiO suggests that the C/O ratio in the atmosphere is higher than the solar value. The detection of metals in the atmosphere of hot Jupiters cooler than UHJs will be useful for understanding the atmospheric structure and formation history of hot Jupiters.
Systematic Difference between Ionized and Molecular Gas Velocity Dispersions in z ∼ 1–2 Disks and Local Analogs
Authors: Girard M. , Fisher D. B. , Bolatto A. D. , Abraham R. , Bassett R. , Glazebrook K. , Herrera-Camus R. , Jiménez E. , Lenkić L. , Obreschkow D. 
Published: March 2021

Abstract
We compare the molecular and ionized gas velocity dispersions of nine nearby turbulent disks, analogs to high-redshift galaxies, from the DYNAMO sample using new Atacama Large Millimeter/submillimeter Array and GMOS/Gemini observations. We combine our sample with 12 galaxies at z ∼ 0.5–2.5 from the literature. We find that the resolved velocity dispersion is systematically lower by a factor 2.45 ± 0.38 for the molecular gas compared to the ionized gas, after correcting for thermal broadening. This offset is constant within the galaxy disks and indicates the coexistence of a thin molecular gas disk and a thick ionized one. This result has a direct impact on the Toomre Q and pressure derived in galaxies. We obtain pressures ∼0.22 dex lower on average when using the molecular gas velocity dispersion, σ
0,mol. We find that σ
0,mol increases with gas fraction and star formation rate. We also obtain an increase with redshift and show that the EAGLE and FIRE simulations overall overestimate σ
0,mol at high redshift. Our results suggest that efforts to compare the kinematics of gas using ionized gas as a proxy for the total gas may overestimate the velocity dispersion by a significant amount in galaxies at the peak of cosmic star formation. When using the molecular gas as a tracer, our sample is not consistent with predictions from star formation models with constant efficiency, even when including transport as a source of turbulence. Feedback models with variable star formation efficiency, ϵ
ff, and/or feedback efficiency, p
*/m
*, better predict our observations.