bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Moderating Effect of Treatment Engagement on Fear-avoidance Beliefs in People With Chronic Low Back Pain
Authors: Marshall Paul W. , Morrison Natalie M.V. , Mifsud Annaleise , Gibbs Mitchell , Khan Naseeb , Meade Tanya 
Published: October 2021

Objectives:
The fear-avoidance model (FAM) is used to explain pain-related disability and design targeted interventions for people with chronic low back pain. While treatment engagement is critical, it is unknown how treatment moderates the FAM.

Methods:
This study examined whether pathways within the FAM were moderated by treatment engagement in 508 people with chronic low back pain. Measures of disability, pain, fear, catastrophizing, anxiety, depression, and self-efficacy were collected through self-report, and descriptors of treatment engaged within the last month (physical activity type, medication, allied and medical health practitioner). Moderated mediation analyses were performed to examine the conditional effect of treatment engagement on fear-avoidance pathways.

Results:
The conditional effect of anxiety on disability was only significant for people who did not report any treatment engagement in the last month (B=1.03, 95% confidence interval: 0.53-1.53, P<0.001). The effect of depression increased for people reporting more different types of treatment in the last month (1 level of treatment increase, B=0.27, 95% confidence interval: 0.05-0.50, P=0.019). Conversely, greater treatment engagement had a positive influence on the mediating effect of self-efficacy. That is, the effect of pain on efficacy reduced with greater treatment engagement, with a concomitant increased effect of self-efficacy on disability.

Discussion:
Clinicians should explore the history and rationale behind patient treatment seeking behavior to ensure this is not reinforcing the negative effects of depressive symptoms on pain-related disability.
Perioperative Intravenous Lidocaine Infusion on Postoperative Recovery in Patients Undergoing Arthroscopic Rotator Cuff Repair Under General Anesthesia
Authors: Kim Seon Ju , Choi Yong Seon , Chun Yong Min , Kim Hye Jin , Han Chunggu , Shin Seokyung 
Published: October 2021

Objective:
Arthroscopic rotator cuff repair (ARCR) is known to cause severe postoperative pain that may interfere with recovery. Intravenous (IV) lidocaine has analgesic, anti-inflammatory, and antihyperalgesic effects, and is being used in various types of surgeries. However, the effect of IV lidocaine in ARCR is not well-known.

Materials and Methods:
Ninety patients undergoing ARCR were randomly allocated to receive IV lidocaine (1.5 mg/kg bolus of 1% lidocaine after anesthesia induction followed by a continuous infusion of 2 mg/kg/h up to 1 h after surgery) or an equal volume of saline. In both groups, an IV patient-controlled analgesia (PCA) device was used that contained fentanyl 10 µg/mL, infused at 1 mL/h with a 1 mL bolus dose. The primary outcome was fentanyl requirements given via IV PCA during the first 24 hours after surgery. Perioperative pain scores and functional recovery were assessed as secondary outcomes.

Results:
The amount of fentanyl administered via IV PCA up to 24 hours after surgery was significantly lower in the lidocaine group compared with the control group (329 [256.2 to 428.3] vs. 394.5 [287.0 to 473.0], P=0.037). The number of PCA bolus attempts were lower in the lidocaine group without statistical significance. There were no differences in postoperative pain scores or functional shoulder scores between the 2 groups.

Discussion:
IV lidocaine appears to be helpful in reducing opioid requirements during the acute postoperative period in patients undergoing ARCR. IV lidocaine may be a viable option as a component of multimodal analgesia in ARCR when regional analgesia is not possible.
The Influence of Hypercapnia and Atmospheric Pressure on the Pao 2/Fio 2 Ratio—Pathophysiologic Considerations, a Case Series, and Introduction of a Clinical Tool*
Authors: Gilissen Vincent J. H. S. , Koning Mark V. , Klimek Markus 
Published: October 2021

OBJECTIVES:
The ratio between Pao
2 and Fio
2 is used as a marker for impaired oxygenation and acute respiratory distress syndrome classification. However, any discrepancy between Fio
2 and o
2 fraction in the alveolus affects the Pao
2/Fio
2 ratio. Correcting the Pao
2/Fio
2 ratios using the alveolar gas equation may result in an improved reflection of the pulmonary situation. This study investigates the difference between standard and corrected Pao
2/Fio
2 in magnitude, its correlation with the mortality of acute respiratory distress syndrome classification, and trends over time.

DESIGN:
A register and a retrospective study combined with the development of a mathematical model to determine the difference between standard and corrected Pao
2/Fio
2 ratio for various levels of Paco
2 and atmospheric pressure.

SETTING:
ICU in a secondary hospital in The Netherlands.

PATIENTS:
Patients admitted to the ICU for pneumonia or acute respiratory distress syndrome. Register cohort: January 1, 2010, till March 1, 2020 (n = 1008). Retrospective cohort: March 1, 2020, till June 1, 2020 (n = 34).

MEASUREMENTS AND MAIN RESULTS:
The register was used to determine the 7-day ICU mortality per acute respiratory distress syndrome classification based on the standard and corrected Pao
2/Fio
2 ratio. The retrospective dataset correlated the Paco
2 with Pao
2/Fio
2 ratio over time in patients with assumed stable oxygenation. The model demonstrated an increased difference between the standard and corrected Pao
2/Fio
2 ratios by a lower Fio
2 and atmospheric pressure and higher Pao
2 and Paco
2. Reclassification of severe acute respiratory distress syndrome resulted in an increase in mortality from 28.1% for standard Pao
2/Fio
2 to 30.6% for corrected Pao
2/Fio
2 ratios. Acute Physiology and Chronic Health Evaluation scores correlated better with 7-day ICU-mortality when corrected Pao
2/Fio
2 ratio was used for classification. For patients with Fio
2 less than 50% (n = 55), change in Paco
2 correlated with change in Pao
2/Fio
2 ratio (r = –0.388; p = 0.003).

INTERVENTIONS:
A corrected Pao
2/Fio
2 ratio was calculated.

CONCLUSIONS:
Correcting the Pao
2/Fio
2 ratio for the alveolar gas equation predominantly affects patients with high ratios between Pao
2 and Fio
2 and Paco
2 and at low atmospheric pressure. Using the corrected Pao
2/Fio
2 ratio for acute respiratory distress syndrome classification results in improved correlation with the 7-day ICU mortality and increases generalization among acute respiratory distress syndrome studies. The authors provide a free, web-based tool.
Application of Human Adipose-Derived Stem cells for Bone Regeneration of the Skull in Humans
Authors: Torres-Guzman Ricardo A. , Huayllani Maria T. , Avila Francisco R. , Maita Karla , Zubair Abba C. , Quinones-Hinojosa Alfredo , Sarabia-Estrada Rachel , Forte Antonio J. 
Published: October 2021

Background:
Archeological archives report cranioplasty as 1 of the oldest surgical procedures; however, it was not until the last century that true advances have been made. Alternative approaches are necessary to achieve optimal closure of the defect with fewer adverse effects. We aim to evaluate the use of human adipose-derived stem cells (hADSCs) alone or seeded in scaffolds as the main treatment for cranial bone defects and to assess human patient outcomes.

Methods:
A systematic review was performed by querying PubMed, Ovid MEDLINE, EMBASE, and Cumulative Index to Nursing and Allied Health Literature databases with the MeSH terms: “adipose-derived stem cells,” “cranial bone defect,” “stromal vascular factor,” “fat grafting,” as well as synonyms in combinations determined by our search strategy. We included human models that used hADSCs as primary therapy. We excluded studies in languages other than English.

Results:
One hundred ninety-four studies were identified after removal of duplicates. Four articles that used hADSCs as the main therapy to treat calvarial defects in humans were included. One article applied the cell therapy alone, and 3 used β-tricalcium phosphate granules as a scaffold to seed the hADSCs.

Conclusions:
Bone regeneration was reached in a short and intermediate period using autologous hADSCs in humans with no major adverse effects in all 4 articles included. A long-term follow-up study (6 years) exhibited late infections and reabsorption of the β-tricalcium phosphate scaffold seeded with hADSCs.
Digital Volumetric Monitoring of Palate Growth in Children With Cleft Lip and Palate
Authors: Ambrosio Eloá Cristina Passucci , Fusco Nathália dos Santos , Carrara Cleide Felício Carvalho , Bergamo Mariel Tavares , Lourenço Neto Natalino , Cruvinel Thiago , Rios Daniela , Almeida Ana Lucia Pompeia Fraga , Soares Simone , Machado Maria Aparecida Andrade Moreira , Oliveira Thais Marchini 
Published: October 2021

Abstract
This study aimed to evaluate longitudinally the volume of the dental arches in children with unilateral cleft lip and palate before and after the rehabilitative plastic surgeries. This is a longitudinal retrospective study was composed by 102 digitized dental casts of children with unilateral complete cleft lip (G1) and cleft lip and palate (G2). The palate volume was evaluated at 3 periods: preoperative (T1), postoperative 1 (T2), and postoperative 2 (T3). The intra- and inter-examiner reliability was analyzed by Wilcoxon test/Dahlberg formula and interclass correlation coefficient, respectively. The intragroup comparison was analyzed by Wilcoxon test and Friedman test followed by post-hoc Dunn test. Mann–Whitney test was applied for the intergroup comparison (α = 5%). G1 had a significant growth at T2 (P = 0.031). G2 demonstrated a positive development at T2, but decreased at T3 (P = 0.003). The intergroup analysis revealed that G2 showed a greater volume at T1 and T2 (P < 0.0001 and P = 0.0024, respectively). T2-T1 exhibited no statistically significant difference (P = 0.262). In conclusion, there was a volumetric increase in the dental arches after cheiloplasty followed by a reduction after palatoplasty. Further investigations are necessary to validate the preliminary results of the present study.
Covid-19 Epidemic Prediction in France : the Multimodal Case
Authors: Quadrat J.-P. 
Published: October 2021

AbstractIn two previous papers we have proposed models to estimate the Covid-19 epidemic when the number of daily positive cases has a bell shaped form that we call a mode. We have observed that each Covid variant produces this type of epidemic shape at a different moment, resulting in a multimodal epidemic shape. We will show in this document that each mode can still be estimated with models described in the two previous papers provides we replace the cumulated number of positive cases y by the cumulated number of positive cases reduced by a parameter P to be estimated. Therefore denoting z the logarithm of y −P, z follows approximately the differential equation ż = b −azr where a, b, r have also to be estimated from the observed data. We will show the obtained predictions on the four French modes April, November 2020, May and September 2021. The comparison between the prediction obtained before the containment decisions made by the French government and the observed data afterwards suggests the inefficiency of the epidemic lockdowns.
Child mental and behavioral health services during the COVID-19 pandemic: Trends and implications for service outcomes during telehealth expansion
Authors: Riley Elizabeth N. , Cordell Kate D. , Shimshock Stephen M. , Lyons John S. , Vsevolozhskaya Olga A. 
Published: October 2021

AbstractTransportation to/from care is a significant barrier to healthcare access and utilization. The novel coronavirus pandemic prompted a widespread expansion of telehealth service delivery throughout much of 2020. We used propensity score matching to generate two comparison groups of children served in a large public mental and behavioral health system between (1) April-December 2019 (pre-pandemic; n=2,794), and (2) between April-December 2020 (during the COVID-19 pandemic, n=2,794), followed by longitudinal linear mixed-effects modelling to explore the relationship between caregiver transportation needs and child-level outcomes. Our analyses indicated a statistically significant association between the resolution of caregiver’s transportation needs and children’s clinical improvement in the 2019 (pre-pandemic) sample; there was no such association found in the 2020 (pandemic) sample. Our findings suggest that the use of telehealth may mitigate the effect of caregiver transportation needs on child-level clinical outcomes.
Reversing the miRNA -5p/-3p stoichiometry reveals physiological roles and targets of miR-140 miRNAs
Authors: Cameron Young , Melissa Caffrey , Janton Christopher , Kobayashi Tatsuya 
Published: October 2021

AbstractThe chondrocyte specific miR-140 miRNAs are necessary for normal endochondral bone growth in mice. miR-140 deficiency causes dwarfism and craniofacial deformity. However, the physiologically important targets of miR-140 miRNAs are still unclear. The miR-140 gene (Mir140) encodes three chondrocyte-specific microRNAs, miR-140-5p, derived from the 5’ strand of primary miR-140, and miR140-3p.1 and -3p.2, derived from the 3’ strand of primary miR-140. miR-140-3p miRNAs are ten times more abundant than miR-140-5p likely due to the non-preferential loading of miR-140-5p to Argonaute proteins. To differentiate the role of miR-140-5p and -3p miRNAs in endochondral bone development, two distinct mouse models, miR140-C>T, in which the first nucleotide of miR-140-5p was altered from cytosine to uridine, and miR140-CG, where the first two nucleotides of miR-140-3p were changed to cytosine and guanine, were created. These changes are expected to alter Argonaute protein loading preference of -5p and -3p to increase -5p loading and decrease -3p loading without changing the function of miR140-5p. These models presented a mild delay in epiphyseal development with delayed chondrocyte maturation. Using RNA-sequencing analysis of the two models, direct targets of miR140-5p, including Wnt11, were identified. Disruption of the predicted miR140-5p binding site in the 3’ untranslated region of Wnt11 was shown to increase Wnt11 mRNA expression and caused a modest acceleration of epiphyseal development. These results show that the relative abundance of miRNA-5p and -3p can be altered by changing the first nucleotide of miRNAs in vivo, and this method can be useful to identify physiologically important miRNA targets.
A molecular framework for proximal secondary vein branching in the Arabidopsis thaliana embryo
Authors: Kastanaki Elizabeth , Blanco-Touriñán Noel , Sarazin Alexis , Sturchler Alessandra , Gujas Bojan , Rodriguez-Villalon Antia 
Published: October 2021

SummaryThe establishment of a closed vascular network in foliar organs is achieved through the coordinated specification of newly recruited procambial cells, their proliferation and elongation. An important, yet poorly understood component of this process, is secondary vein branching; a mechanism employed in Arabidopsis thaliana cotyledons to extend vascular tissues throughout the organ’s surface by secondary vein formation.To investigate the underlying molecular mechanism in vein branching, we analyzed at a single-cell level the discontinuous vein network of cotyledon vascular pattern 2 (cvp2) cvp2-like 1 (cvl1). Utilizing live-cell imaging and genetic approaches we uncovered two distinct branching mechanisms during embryogenesis.Similar to wild type, distal veins in cvp2 cvl1 embryos emerged from the bifurcation of cell files contained in the midvein. However, the branching events giving rise to proximal veins are absent in this mutant. Restoration of proximal branching in cvp2 cvl1 cotyledons could be achieved by increasing OCTOPUS dosage as well as by silencing of RECEPTOR LIKE PROTEIN KINASE 2 (RPK2) expression. The RPK2-mediated restriction of proximal branching is auxin and CLE-independent.Our work defines a genetic network conferring plasticity to Arabidopsis embryos to adapt the spatial configuration of vascular tissues to organ growth.
Torque vectoring control system for distributed drive electric bus under complicated driving conditions
Authors: Su Liang , Wang Zhenpo , Chen Chao 
Published: October 2021

Purpose
The purpose of this study is to propose a torque vectoring control system for improving the handling stability of distributed drive electric buses under complicated driving conditions. Energy crisis and environment pollution are two key pressing issues faced by mankind. Pure electric buses are recognized as the effective method to solve the problems. Distributed drive electric buses (DDEBs) as an emerging mode of pure electric buses are attracting intense research interests around the world. Compared with the central driven electric buses, DDEB is able to control the driving and braking torque of each wheel individually and accurately to significantly enhance the handling stability. Therefore, the torque vectoring control (TVC) system is proposed to allocate the driving torque among four wheels reasonably to improve the handling stability of DDEBs.

Design/methodology/approach
The proposed TVC system is designed based on hierarchical control. The upper layer is direct yaw moment controller based on feedforward and feedback control. The feedforward control algorithm is designed to calculate the desired steady-state yaw moment based on the steering wheel angle and the longitudinal velocity. The feedback control is anti-windup sliding mode control algorithm, which takes the errors between actual and reference yaw rate as the control variables. The lower layer is torque allocation controller, including economical torque allocation control algorithm and optimal torque allocation control algorithm.

Findings
The steady static circular test has been carried out to demonstrate the effectiveness and control effort of the proposed TVC system. Compared with the field experiment results of tested bus with TVC system and without TVC system, the slip angle of tested bus with TVC system is much less than without TVC. And the actual yaw rate of tested bus with TVC system is able to track the reference yaw rate completely. The experiment results demonstrate that the TVC system has a remarkable performance in the real practice and improve the handling stability effectively.

Originality/value
In view of the large load transfer, the strong coupling characteristics of tire , the suspension and the steering system during coach corning, the vehicle reference steering characteristics is defined considering vehicle nonlinear characteristics and the feedforward term of torque vectoring control at different steering angles and speeds is designed. Meanwhile, in order to improve the robustness of controller, an anti-integral saturation sliding mode variable structure control algorithm is proposed as the feedback term of torque vectoring control.
Marketing mix strategies during and after COVID-19 pandemic and recession: a systematic review
Authors: Nikbin Davoud , Iranmanesh Mohammad , Ghobakhloo Morteza , Foroughi Behzad 
Published: October 2021

PurposeThis study aims to answer two important questions: (1) Whether companies should reduce or increase the marketing expenses to face the recession caused by COVID-19? and (2) What marketing mix strategies should companies undertake to shine in the post-pandemic world?Design/methodology/approachAs recession caused by the COVID-19 crisis is one of the main drivers of business environment and customer behaviour changes, the authors systematically reviewed articles on marketing mix strategies during recessions. Out of 1,128 documents extracted from the Scopus database, 41 English-written articles were selected and analysed.FindingsThis study illustrates: (1) marketing budgets should not be cut during COVID-19 and (2) the marketing mix practices and strategies that firms should undertake during COVID-19 pandemic in terms of product, price, promotion, and place were explained.Originality/valueThe findings of this study advance the understanding of marketing strategies and practices that should be adopted and put into practice to deal with the impacts of COVID-19 on the business environment and shine in the post-COVID-19 world.
The impact of employment relationships on firm sustainability
Authors: Rincon-Roldan Francisco , Lopez-Cabrales Alvaro 
Published: October 2021

PurposeThe aim of this study was to analyse the influence of different employment relationships (ERs) on the sustainability results of cooperatives. The authors approached the type of ER comparing the inducements offered by the firm with the contributions that the manager expects from employees. In this way, the authors study how the orientation toward the employment relationship influences the economic, social and environmental sustainability of the firm.Design/methodology/approachThis article presents a theoretical and empirical research model about the relationship between ERs and sustainability. The necessary information was obtained through a questionnaire that was completed by the human resource (HR) managers and chief executive officers (CEOs) of 124 cooperative companies, and structural equation modelling was applied to evaluate the relationships between the proposed constructs, using the partial least squares technique (PLS-SEM).FindingsThe obtained results suggest that mutual investment and overinvestment ERs favour economic, social and environmental sustainability, whereas quasi spot contract and underinvestment ERs have a negative influence on all three types of sustainability. Therefore, it is confirmed that the type of ER adopted can condition the sustainability of the company, either favouring or worsening it.Originality/valueThis work contributes to covering the lack of studies about which ERs impact the sustainability of organisations, and it provides information on the role of ERs in the search for a more sustainable organisation, demonstrating that the type of employment relationship developed by the firm has a relevant impact on its sustainability.
Interaction and acoustics of separated flows from a D-shaped bluff body
Authors: Huang Guangyuan , Seid Ka Him , Yang Zhigang , Leung Randolph Chi Kin 
Published: October 2021

PurposeFor flow around elongated bluff bodies, flow separations would occur over both leading and trailing edges. Interactions between these two separations can be established through acoustic perturbation. In this paper, the flow and the acoustic fields of a D-shaped bluff body (length-to-height ratioL/H= 3.64) are investigated at height-based Reynolds numberRe= 23,000 by experimental and numerical methods. The purpose of this paper is to study the acoustic feedback in the interaction of these two separated flows.Design/methodology/approachThe flow field is measured by particle image velocimetry, hotwire velocimetry and surface oil flow visualization. The acoustic field is modeled in two dimensions by direct aeroacoustic simulation, which solves the compressible Navier–Stokes equations. The simulation is validated against the experimental results.FindingsSeparations occur at both the leading and the trailing edges. The leading-edge separation point and the reattaching flow oscillate in accordance with the trailing-edge vortex shedding. Significant pressure waves are generated at the trailing edge by the vortex shedding rather than the leading-edge vortices. Pressure-based cross-correlation analysis is conducted to clarify the effect of the pressure waves on the leading-edge flow structures.Practical implicationsThe understanding of interactions of separated flows over elongated bluff bodies helps to predict aerodynamic drag, structural vibration and noise in engineering applications, such as the aerodynamics of buildings, bridges and road vehicles.Originality/valueThis paper clarifies the influence of acoustic perturbations in the interaction of separated flows over a D-shaped bluff body. The contribution of the leading- and the trailing-edge vortex in generating acoustic perturbations is investigated as well.