bluuebunny/crossref_metadata_2025_split huggingface dataset:
#3085 Relationship between variant connective tissue (hypermobility) and autism sensory processing: externally oriented thinking as a mediator
Authors: Savage GK , Csecs JLL , Davies G , Critchley HD , Eccles JA 
Published: July 2021

Objectives/AimsAutism is a neurodevelopmental condition characterised by differences in sensory processing, social communication and restricted/repetitive behaviors. Joint hypermobility is a common connective tissue variant, reportedly overrepresented in Autism. Alexithymia is a personality construct characterised by altered emotional awareness which has notably high rates of overlap with autism spectrum disorder. This study tested whether hypermobility was associated with autistic traits and examined alexithymia as a mediator of this association.MethodForty-two people underwent eligibility assessment for a study of joint hypermobility and anxiety (ISRCTN17018615). Hypermobility was assessed using both the Brighton Criteria for Joint Hypermobilty Syndrome (JHS) and 2017 Hypermobile Ehlers Danlos Syndrome (hEDS) Criteria. Participants completed the Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS R: sensory/motor, language, social relatedness and circumscribed interest domains) to quantify autistic traits. No participant had a prior diagnosis of Autism. Participants also completed the Toronto Alexithymia Scale (TAS-20) to measure alexithymia. The TAS-20 has three domains: difficulty describing feelings, difficulty identifying feelings and externally oriented thinking.ResultsAll 42 participants met criteria for JHS, 26 participants also met criteria for hEDS. Strikingly, 22/42 (52.4%) scored above threshold for suspected Autism (26/42 in the sensory/motor domain; 22/42 in language domain; 22/42 in social relatedness domain; 17/42 in circumscribed interests domain). There were no significant differences in RAADS-R scores depending on hypermobility diagnosis. The number of connective tissue features (hEDS Criterion 2A) correlated with RAADS-R sensory/motor score (r = 0.418, p = 0.006) but not social relatedness nor circumscribed interests sub-scores. Full mediation of the relationship between the number of connective tissue features and RAADs sensory/motor score by TAS-20 externally oriented thinking was found using the method of Baron-Kenny (1986) and estimation of indirect effects (Hayes, 2018; bootstrapped confidence intervals (n = 5000, do not cross zero)). Difficulty identifying feelings and difficulty describing feelings domains did not mediate this relationship.ConclusionThese results add to evidence linking variant connective tissue to neurodevelopmental conditions (including Autism) and interestingly, specifically to sensory processing differences. Our study provides a strong rationale for screening for neurodevelopmental conditions in people with hypermobility and motivates further to understand symptom expression in this group. Our results also provide an insight into the processes underlying this relationship, which maybe important for informing interventions for people with hypermobility and autistic traits.
#3031 Outcome and evaluation of an outpatient multidisciplinary group-based rehabilitative therapy programme for functional neurological disorder
Authors: Guy Lisette , Gorman Sean , Wilson Jennifer , Jackson Temeika , Petty Demelza , Harrison Simon , Pick Susannah 
Published: July 2021

AimsWe report findings from an eight-week rehabilitative therapy programme, delivered in a neuropsychiatric outpatient setting, with co-primary aims to (1) reduce symptom severity, and (2) improve functional mobility, in selected adults with a diagnosis of Functional Neurological Disorder (FND). Effectiveness of the programme was assessed in regard to outcome data routinely collected throughout the programme, and at three-month follow-up.MethodFollowing appropriate referral, criteria screening and initial assessment, suitable individuals attended as day patients for two days per week over an eight-week period, and a follow-up session provided at three months. The programme comprised individual sessions of Physiotherapy (PT), Cognitive Behavioural Therapy (CBT) and self-management, as well as group physiotherapy workshops and psycho-educational sessions. Outcome measures included the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI-ii), Work and Social Adjustment Scale (WSAS), and clinician-rated observation of mobility-aid requirement. Mobility-aid requirement was categorised as follows: unaided, walking-aid, and wheelchair user. Analyses included only data from individuals completing both treatment and follow-up (n = 31). Friedmans ANOVA assessed overall change in outcome measure scores over time. Dunn-Bonferroni post-hoc tests were used to compare pairs of time-points (Weeks 1, 8, three-month follow-up).ResultsThere were statistically significant overall improvements on the BAI,χ2(2) = 15.35, p <.001,BDI-ii,χ2(2) = 24.61, p <.001,WSAS,χ2(2) = 24.61, p =.001, and in category of mobility-aid requirement, χ2(2) = 19.50, p <.001.Descriptive statistics indicated that 45% of patients could mobilise unaided prior to programme attendance, with 84%able to mobilise unaided at follow-up. Post-hoc Dunn-Bonferroni tests indicated that reductions in scores were significant between Week 1 and Week 8 for the BAI, p =.004, BDI-ii, p <.001, and WSAS, p =.004, and between Week 1 and three-month follow-up for the BAI, p =.002, BDI-ii, p =.001, and WSAS, p =.006.ConclusionsThese findings suggest that an outpatient rehabilitative therapy programme can be a beneficial treatment approach, as patients reported reduced symptom severity in terms of anxiety, depression, and functional impairment, as demonstrated by scores on the BAI, BDI-ii and WSAS, and displayed improvements in mobility, as determined by reduced mobility-aid requirement. Although further evaluation would be encouraged to address limitations of these findings, they serve as a positive indication of an effective alternative to inpatient treatment.
#3119 Diagnosis and management of functional neurological symptoms: Saudi Arabia experience
Authors: Khoja Lujain , Khoja Abeer , Shaaban Saeed , Tayeb Haythum 
Published: July 2021

ObjectivesTo explore the opinion of todays neurologist and psychiatrist in the kingdom of Saudi Arabia regarding pathogenesis, diagnosis, treatment and outcome. It is a replication for Dutch experience with Functional Neurological symptoms Disorder (FND).MethodsA multi-centres Cross-sectional study was conducted in Saudi Arabia started from November 2019 and still ongoing. The target populations were a qualified psychiatrists or neurologists. Data were collected through an electronic questionnaire.ResultsThere were 70 respondents, 37.1% were female and 62.9% males. A 15.5% were Neurologists and 72.4% psychiatrists. Three questionnaires were taken out due to incompletion error. Most neurologists and psychiatrists believed that FND is a disorder of functioning of the nervous system together with psychogenic factors. However, 100% of psychiatrist believed that a prior psychological stress is a cause of the disorder (among other causes) while 86.84% of neurologists. Also found that, a 71% of patients who referred to neurologist were evaluated initially by a general practitioner, while 85% of the patients who referred to psychiatrist; were evaluated by neurologists. Eventually, most of the neurologists and the psychiatrists diagnosed patients by conversion disorder (13/38 of neurologist and 13/20 of psychiatrists).ConclusionOur preliminary conclusion is comparable for Dutch experience that is not considered purely a psychiatric disorder and counted disordered brain functioning together with psychogenic factors responsible for FNS. However, the majority of the psychiatrists in our study diagnose FND as conversion disorder.
#3115 Systematic review into the effects of sleep disorders on the development of PTSD
Authors: Millar Samuel J , Miorelli Ana 
Published: July 2021

ObjectivesTo examine if sleep problems act as a risk factor for future PTSD development in military, child, and general adult demographics. We will also be examining specific sleep disorders, such as nightmares and insomnia, as well as examining general sleep complaints in a series of sub-sections (REM sleep, Sleep duration, quality, latency, and maintenance) to see if it is possible with the current literature to discover potential hints into the development of PTSD.MethodsSix databases (Medline, Embase, Web of Science, Psych info, AMED, and OpenGray) were searched with a standardised search strategy. The papers were then screened for relevance and quality controlled using the Ottowa-Newcastle Scale and the CASP cohort checklist by two reviewers until only relevant and high quality cohort studies remained. Relevant information and data was extracted from published sources and information on insomnia, nightmares, REM sleep, and 4 specific sleep subcategories (sleep duration, quality, latency, and maintenance) were gathered and examined. Nometa-analysis was planned.ResultsOut of the 1813 documents gathered from the various databases, 25 papers were deemed fit for narrative synthesis. 19 discussed insomnia or general sleep complaints, and found that those tended to correlate with development of future PTSD, with little distinction between if the insomnia appeared pre or post-trauma. 6 discussed nightmares and found that those too were predictive, and 2 discussed REM sleep and found that REM theta waves were potentially predictive.ConclusionIt is almost certain that complaints of poor sleep predict future PTSD development, with insomnia being predictive of many psychiatric conditions not just PTSD, and nightmares being more specific to the development of just PTSD. It has also been suggested that only subjectively (not objectively) poor sleep predicts PTSD. This would explain why specific sleep categories all have mostly mixed results, but the idea is not backed completely in the literature.
#3121 Adapting the queen square guided self help (QGSH) for functional neurological disorders as a stand-alone intervention: an exonian pilot study
Authors: Sachdeva Jasjeet , Selai Caroline , Moutoussis Michael 
Published: July 2021

AimFunctional neurological disorders (FND) are one of the most common presentation in neurology clinics, causing a significant disability and economic burden. Cognitive behavioural therapy (CBT) has one of the best available evidence in managing FND, although access remains limited. Queen Square, London neuropsychiatry experts have established an excellent model for a CBT based, Guided Self Help (GSH) programme, which is preparatory to a multidisciplinary inpatient treatment. It has been shown to have good outcomes. This study was designed to ascertain the feasibility and acceptance of this QGSH model, in an Exonian cohort of FND patients, whilst piloting its stand-alone version, without the inpatient component. Additionally, the study explores the need and types of modifications required for the stand-alone adaptation of QGSH.MethodConsecutive patients referred to Exeter FND Service, between February to June 2020, who had internet access, were offered the QGSH pilot. Patients with a primary mental disorder concurrent drug/alcohol misuse or risk of self-harm or suicide were excluded. Ethics approval was not required. The QGSH intervention constitutes of 11 modules focussing on specific elements crucial to FND management along with homework tasks, delivered by the author, under supervision by QGSH experts. Patients completed Pre and Post-intervention questionnaires as well as structured feedback.ResultsThree successive patients with varied FND symptoms were recruited to the pilot between February and June 2020. The baseline health status of these patients was worse as compared to EQ-5D-5L population norms with significant baseline psychiatric comorbidity. Outcome measures used before and after QGSH intervention included PHQ 9, GAD 7, EQ-5D-5L and a locally devised symptom severity questionnaire. Necessary modifications were made to the program based on the patients informal feedback and structured formal feedback was sought in the end.ConclusionAll patients derived some benefit from QGSH and certain modifications were suggested in patient feedback to improve engagement. Despite study limitations, especially small size and the impact of Covid 19 pandemic during the intervention; QGSH model appears acceptable and feasible in an Exonian cohort, however, some modifications are recommended for the stand-alone version to succeed. The recommendations will be presented.
Increased risk of subsequent chlamydia infection among women not tested at the anorectal anatomical location
Authors: Visser Maartje , Dvorakova Milada , van Aar Fleur , Heijne Janneke C M 
Published: July 2021

BackgroundUniversal anorectal testing for Chlamydia trachomatis (chlamydia) among women is not recommended in many countries, while anorectal chlamydia infections are common. Missed anorectal infections might cause sequelae at the genital site if autoinoculation from the anorectum is possible, but evidence is limited. This study investigates the association between potentially missed anorectal infections and subsequent genital chlamydia infections in women, using not being tested at the anorectal site as a proxy for having a potentially missed anorectal infection.MethodsWe included all women with a repeat chlamydia test within 1 year (with at least a genital test) from the Dutch sexual health centre surveillance between 2014 and 2019. Multilevel logistic regression analyses were used to identify determinants of genital chlamydia infection at the repeat test, with anorectal testing at the previous chlamydia test as the main determinant.ResultsA total of 40 217 women were included in the analyses, of whom 15.4% tested chlamydia-positive genitally at their second test. Not being tested anorectally at the first test was an independent risk factor for genital chlamydia infection at the repeat test (adjusted OR 1.24, 95% CI 1.15 to 1.33). This association was in the same range as most other significant risk factors in the model: low education level, no condom use, STI symptoms and previous STI diagnosis. Young age (<20 years) (2.67, 2.39–2.98) and those who received partner notification (3.11, 2.91–3.31) showed stronger associations. The findings were robust; correcting for interactions and a sensitivity analysis stratifying by chlamydia infection at first visit did not show significant differences in the adjusted OR of not being tested anorectally at first test.ConclusionThe results are suggestive of an autoinoculation process from the anorectal to the genital anatomical site in women. To enhance chlamydia control, future studies on the role of extragenital testing and autoinoculation in chlamydia transmission are needed.
Variations in phytochemistry, morphology, and population structure inTrillium govanianum(Melanthiaceae)
Authors: Chauhan Harsh Kumar , Gallacher David , Bisht Anil Kumar , Bhatt Indra Dutt , Bhatt Arvind , Dhyani Praveen , Kewlani Pushpa 
Published: July 2021

As habitats change, species with higher intraspecific variation have more resources to adapt. Medicinal plants in the Himalayas are increasingly threatened by climate change and other anthropogenic influences. The intraspecific variation within and among 17 populations of the high-elevation herb Trillium govanianum Wall. ex D.Don was studied as an indicator of adaptability. The variation in 19 traits of population structure, morphology, and phytochemistry was assessed across habitats that varied in elevation (2452–3432 m a.s.l.), aspect, latitude (30.1–31.7°N), and arboreal community. The morphology and population structure were conserved among populations but varied among regions. The populations in the lower elevation mixed forests of Tirthan Valley produced smaller rhizomes but larger plant densities, such that plant biomass per square metre was conserved. The phytochemistry varied among regions and populations within regions, indicating significant variation among habitats. The aboveground morphology of the species masks considerable variations in belowground morphology and phytochemistry. The observed variations can help the species to adapt to the changing environmental conditions by provoking a functional response.
Linear dichroism in few-photon ionization of laser-dressed helium
Authors: Meister Severin , Bondy Aaron , Schnorr Kirsten , Augustin Sven , Lindenblatt Hannes , Trost Florian , Xie Xinhua , Braune Markus , Manschwetus Bastian , Schirmel Nora , Redlin Harald , Douguet Nicolas , Pfeifer Thomas , Bartschat Klaus , Moshammer Robert 
Published: July 2021

Abstract
Ionization of laser-dressed atomic helium is investigated with focus on photoelectron angular distributions stemming from two-color multi-photon excited states. The experiment combines extreme ultraviolet (XUV) with infrared (IR) radiation, while the relative polarization and the temporal delay between the pulses can be varied. By means of an XUV photon energy scan over several electronvolts, we get access to excited states in the dressed atom exhibiting various binding energies, angular momenta, and magnetic quantum numbers. Furthermore, varying the relative polarization is employed as a handle to switch on and off the population of certain states that are only accessible by two-photon excitation. In this way, photoemission can be suppressed for specific XUV photon energies. Additionally, we investigate the dependence of the photoelectron angular distributions on the IR laser intensity. At our higher IR intensities, we start leaving the simple multi-photon ionization regime. The interpretation of the experimental results is supported by numerically solving the time-dependent Schrödinger equation in a single-active-electron approximation.

Graphic abstract
The Combined Basic LP and Affine IP Relaxation for Promise VCSPs on Infinite Domains
Authors: Viola Caterina , Živný Stanislav 
Published: July 2021

Convex relaxations have been instrumental in solvability of constraint satisfaction problems (CSPs), as well as in the three different generalisations of CSPs: valued CSPs, infinite-domain CSPs, and most recently promise CSPs. In this work, we extend an existing tractability result to the three generalisations of CSPs combined: We give a sufficient condition for the combined basic linear programming and affine integer programming relaxation for exact solvability of promise valued CSPs over infinite-domains. This extends a result of Brakensiek and Guruswami (SODA’20) for promise (non-valued) CSPs (on finite domains).
Augmented Reality Applications to Support the Promotion of Cultural Heritage
Authors: Cisternino Doriana , Corchia Laura , Luca Valerio De , Gatto Carola , Liaci Silvia , Scrivano Liliana , Trono Anna , De Paolis Lucio Tommaso 
Published: July 2021

The intent of this study is to promote and raise awareness of the Basilica of Saint Catherina of Alexandria in Galatina, a church endowed with such beauty as to be defined as astounding.
In this article two technologies were used: Spatial Augmented Reality, better known as videomapping, to valorize the monument and narrate its story through images and sounds; and Augmented Reality, to facilitate the reading and interpretation of the most important frescoes located along all the internal walls of the Basilica. The goal is to create a unique path starting from the Basilica façade and continuing and winding through the interior spaces. One of the most extensive and best conserved cycles of Late Gothic frescoes in all of Europe unfolds on the nave of the church covering every corner, from the keystones down to the floor.
An in-depth bibliographic research confirmed the presence of frescoes also on the exterior of the Basilica façade whose traces, however, are no longer visible today. Pietro Cavoti’ s illustrations give an idea of how the façade has changed over the years, before, during, and after the restorations that permanently removed the already faint traces of frescoes.
The purpose of this research is to demonstrate how the combined use of these technologies can be considered a valid aid to support the enhancement, fruition, and understanding of a monument that is very important for the cultural heritage sector and a reference point for the local and religious community.
Report on the future conversations workshop at CHIIR 2021
Authors: Spina Damiano , Trippas Johanne R. , Thomas Paul , Joho Hideo , Byström Katriina , Clark Leigh , Craswell Nick , Czerwinski Mary , Elsweiler David , Frummet Alexander , Ghosh Souvick , Kiesel Johannes , Lopatovska Irene , McDuff Daniel , Meyer Selina , Mourad Ahmed , Owoicho Paul , Cherumanal Sachin Pathiyan , Russell Daniel , Sitbon Laurianne 
Published: July 2021

The Future Conversations workshop at CHIIR'21 looked to the future of search, recommendation, and information interaction to ask: where are the opportunities for conversational interactions? What do we need to do to get there? Furthermore, who stands to benefit?The workshop was hands-on and interactive. Rather than a series of technical talks, we solicited position statements on opportunities, problems, and solutions in conversational search in all modalities (written, spoken, or multimodal). This paper -co-authored by the organisers and participants of the workshop- summarises the submitted statements and the discussions we had during the two sessions of the workshop. Statements discussed during the workshop are available at https://bit.ly/FutureConversations2021Statements.
Pulling a Yoke through the White Field: East Syriac Poetic Paraphrases of Scribal Rhetoric
Authors: Pritula Anton 
Published: July 2021

Abstract
As shown in recent studies, East Syriac colophons were rather standardised, at least in the Ottoman period, and they incorporated into the main colophon body not only prose passages, but also poetic ones. The current article discusses one such passage that occurs in both prose and poetic forms in various manuscripts, namely the topos of ‘the five twins that pulled a yoke from the forest through the white field’. It provides a fascinating example of the trope’s transmission over the centuries, as well as the poetic creativity of East Syriac scribes as manifested in the Ottoman period.
Contesting the Political: Violence, Emotion and the Playful Subject
Authors: Rogers Peter 
Published: July 2021

Abstract
Tabletop role-play games (TRPG s) are undergoing a resurgence in popularity tied, in part, to the release of Dungeons and Dragons (5th edition) and a vibrant culture of live-streaming role-play games online. Research has now also shown that TRPG s – such as Dungeons and Dragons – provide a unique environment for the development of prosocial behaviours. There is an opportunity for researchers interested in political emotions and ideological performance to explore a community of collaborative storytelling where the altruism derided by philosophies of neoliberal economic rationalism is performed as a core value, with tangible outcomes for tolerance, generosity and well-being. As TRPG s become commonly accepted as part of the toolkit in both education and therapeutic contexts, they provide a new avenue of engagement for those interested in the development of prosocial values, community and social inclusion in the digital age.