bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endocrine disorders in patients with Fabry disease: insights from a reference centre prospective study
Authors: Bothou Christina , Beuschlein Felix , Nowak Albina 
Published: November 2021

Abstract
Context
Fabry Disease (FD) is a rare X-linked storage disease characterised by a-galactosidase A deficiency and diffuse organ accumulation of glycosphingolipids. Enzyme replacement and chaperone therapies are only partially effective. It remains unclear if FD-related endocrine disorders contribute to the observed morbidity.

Objective
To investigate the function of the endocrine system in patients with FD.

Design
We conducted an observational prospective study from 2017 to 2020.

Setting and patients
We included 77 patients with genetically confirmed FD (27 men, 20/27 Classic, 7/26 Late Onset phenotype, 50 women, 41/50 and 9/50 respectively), who are systematically followed by our reference centre.

Results
36/77 (46.8%) patients had VitD deficiency (25(0H)VitD <20 μg/L) despite the fact that 19/36 (52.8%) were substituted with cholecalciferol. Only 21/77 (27.3%) patients had normal VitD levels without VitD substitution. 11/77 (14.3%) had significant hypophosphatemia (p < 0.80 mmol/L). Three new cases (3.9%) of subclinical, two (2.6%) of overt and six (7.8%) of known hypothyroidism were identified. Of note, men had significantly higher renin levels than women [61.4 (26.1–219.6) vs.25.4 (10.9–48.0) mU/L, p = 0.003]. There were no major abnormalities in adrenal, growth and sex-hormone axes. Patients of Classic phenotype had significantly higher High-Density Lipoprotein Cholesterol (HDL-C) levels (p = 0.002) and in men those levels were positively correlated with globotriaosylsphingosin (Lyso-Gb3) values. 10/77 (13%) of the patients were underweight.

Conclusions
VitD supplementation should be considered for all patients with FD. Thyroid screening should be routinely performed. Malnutrition should be prevented or treated, particularly in Classic phenotype patients. Overall, our data suggest that FD specialists should actively seek and diagnose endocrine disorders in their patients.
Experimental simulation of proppant permeability in hydraulic fracturing at extended time under bottom-hole conditions
Authors: Guenaoui Ali Seyfeddine , Dobbi Abdelmadjid , Lebtahi Hamid , Zerrouki Ahmed Ali 
Published: November 2021

AbstractDuring hydraulic fracturing treatment, huge quantities of gel are pumped into the formation to initiate the fracture, maintain it open and transport the proppant. The fracture dimensionless conductivity (Fcd) is a key parameter to optimize the fracturing design, to estimate the productivity Index (PI) and the folds of increase (FOI). However, these parameters are affected by the gel residues which decrease the fracture conductivity; thus, the proppant cleanup is a very important step to avoid additional damage caused by fracturing fluid due to high gel concentration and the extended time of gel staying in the fracture before cleanup. Throughout the life of Hassi Messaoud, Algeria field, hydraulic fracturing technique has been aggressively used mainly in four producing formations in the Cambrian, with hard formation characteristics, an average permeability range and low reservoir pressure (0.15–0.45 psi/ft) and high stress value between 6000 and 9000 psi. In this paper, an experimental simulation is applied using a self-made cell to determine the effect of different parameters on the fracture conductivity under various bottom-hole conditions where different variables were used: effect of Proppant type, guar gel concentration, temperature, breaker concentration and closure pressure at extended time. An important drop in fracture conductivity was observed varied between 10 and 80% under stresses at interval of 2000 psi and 8000 psi, gel concentration up to 200 lb/1000 gal at extended time and temperature.
A Critical Review of Social Resilience Properties and Pathways in Disaster Management
Authors: Saja A. M. Aslam , Teo Melissa , Goonetilleke Ashantha , Ziyath Abdul M. 
Published: November 2021

AbstractResilience as a concept is multi-faceted with complex dimensions. In a disaster context, there is lack of consistency in conceptualizing social resilience. This results in ambiguity of its definition, properties, and pathways for assessment. A number of key research gaps exist for critically reviewing social resilience conceptualization, projecting resilience properties in a disaster-development continuum, and delineating a resilience trajectory in a multiple disaster timeline. This review addressed these research gaps by critically reviewing social resilience definitions, properties, and pathways. The review found four variations in social resilience definitions, which recognize the importance of abilities of social systems and processes in disaster phases at different levels. A review of resilience properties and pathways in the disaster resilience literature suggested new resilience properties—“risk-sensitivity” and “regenerative” in the timeline of two consecutive disasters. This review highlights a causal pathway for social resilience to better understand the resilience status in a multi-shock scenario by depicting inherent and adaptive resilience for consecutive disaster scenarios and a historical case study for a resilience trajectory in a multiple disaster timeline. The review findings will assist disaster management policymakers and practitioners to formulate appropriate resilience enhancement strategies within a holistic framework in a multi-disaster timeline.
Utilizing the Chinese Diaspora by Russian Firms: Capabilities and Legitimacy Implications
Authors: Kostova Tatiana , Panibratov Andrei , Rysakova Liana 
Published: November 2021

ABSTRACTThis article examines the impact of foreign diasporas on host country firms. It contributes to diaspora research by focusing on the context of emerging market host countries and the specific case of Chinese diaspora in Russia. Drawing on the concepts of organizational capabilities and organizational legitimacy, we explain how the Chinese diaspora can be beneficial for the competitiveness of Russian firms, and how Russian firms can uniquely leverage these potential benefits through engagement with individual Chinese diasporans and diaspora institutions. Our article adds to the diaspora literature in several ways. First, unlike the majority of past research, which tends to focus on the benefits for the diaspora's home country, we highlight the potential impact on host country firms, specifically their capabilities and legitimacy at home and abroad. Second, our model can be viewed as a direct response to the many calls in the literature to study the microfoundations of firms’ capabilities. Third, we add to the legitimacy literature by proposing that engagement with a foreign diaspora can help host country firms establish and maintain their legitimacy both at home and on a global scale. Although our framework is informed by the Chinese diaspora in Russia, we discuss its generalizability to other contexts.
Comparison of methods to identify individuals with obesity at increased risk of functional impairment among a population of home-dwelling older adults
Authors: Nordengen Anne Lene , Øyri Linn Kristin Lie , Ulven Stine Marie , Raastad Truls , Holven Kirsten Bjørklund , Ottestad Inger 
Published: November 2021

AbstractObesity is associated with increased muscle mass and muscle strength. Methods taking into account the total body mass to reveal obese older individuals at increased risk of functional impairment are needed. Therefore, we aimed to detect methods to identify obese older adults at increased risk of functional impairment. Home-dwelling older adults (n 417, ≥ 70 years of age) were included in this cross-sectional study. Sex-specific cut-off points for two obesity phenotypes (waist circumference (WC) and body fat mass (FM %)) were used to divide women and men into obese and non-obese groups, and within-sex comparisons were performed. Obese women and men, classified by both phenotypes, had similar absolute handgrip strength (HGS) but lower relative HGS (HGS/total body mass) (P < 0·001) than non-obese women and men, respectively. Women with increased WC and FM %, and men with increased WC had higher appendicular skeletal muscle mass (P < 0·001), lower muscle quality (HGS/upper appendicular muscle mass) (P < 0·001), and spent longer time on the stair climb test and the repeated sit-to-stand test (P < 0·05) than non-obese women and men, respectively. Absolute muscle strength was not able to discriminate between obese and non-obese older adults. However, relative muscle strength in particular, but also muscle quality and physical performance tests, where the total body mass was taken into account or served as an extra load, identified obese older adults at increased risk of functional impairment. Prospective studies are needed to determine clinically relevant cut-off points for relative HGS in particular.
Impact of data extraction errors in meta-analyses on the association between depression and peripheral inflammatory biomarkers: an umbrella review
Authors: Lee San , Lee Keum Hwa , Park Kyung Mee , Park Sung Jong , Kim Won Jae , Lee Jinhee , Kronbichler Andreas , Smith Lee , Solmi Marco , Stubbs Brendon , Koyanagi Ai , Jacob Louis , Stickley Andrew , Thompson Trevor , Dragioti Elena , Oh Hans , Brunoni Andre R. , Carvalho Andre F. , Radua Joaquim , An Suk Kyoon , Namkoong Kee , Lee Eun , Shin Jae Il , Fusar-Poli Paolo 
Published: November 2021

AbstractBackgroundAccumulating evidence suggests that alterations in inflammatory biomarkers are important in depression. However, previous meta-analyses disagree on these associations, and errors in data extraction may account for these discrepancies.MethodsPubMed/MEDLINE, Embase, PsycINFO, and the Cochrane Library were searched from database inception to 14 January 2020. Meta-analyses of observational studies examining the association between depression and levels of tumor necrosis factor-α (TNF-α), interleukin 1-β (IL-1β), interleukin-6 (IL-6), and C-reactive protein (CRP) were eligible. Errors were classified as follows: incorrect sample sizes, incorrectly used standard deviation, incorrect participant inclusion, calculation error, or analysis with insufficient data. We determined their impact on the results after correction thereof.ResultsErrors were noted in 14 of the 15 meta-analyses included. Across 521 primary studies, 118 (22.6%) showed the following errors: incorrect sample sizes (20 studies, 16.9%), incorrect use of standard deviation (35 studies, 29.7%), incorrect participant inclusion (7 studies, 5.9%), calculation errors (33 studies, 28.0%), and analysis with insufficient data (23 studies, 19.5%). After correcting these errors, 11 (29.7%) out of 37 pooled effect sizes changed by a magnitude of more than 0.1, ranging from 0.11 to 1.15. The updated meta-analyses showed that elevated levels of TNF- α, IL-6, CRP, but not IL-1β, are associated with depression.ConclusionsThese findings show that data extraction errors in meta-analyses can impact findings. Efforts to reduce such errors are important in studies of the association between depression and peripheral inflammatory biomarkers, for which high heterogeneity and conflicting results have been continuously reported.
From volunteer work to informal care by stealth: a ‘new voluntarism’ in social democratic health and welfare services for older adults
Authors: Ågotnes Gudmund , Moholt Jill-Marit , Blix Bodil H. 
Published: November 2021

AbstractIn the context of current and expected demographic changes, the issues of which services the welfare state should offer and, ultimately, the very function of the welfare state are currently debated in Norway. The political discourse on health and care services for older adults has morphed into an accepted reality in which the system must be altered, prompting policy makers and stakeholders to find new and novel solutions to problems associated with population ageing. In this paper, we discuss one such proposed solution: the transformation of health and care services for the older adult population through the increased involvement of volunteers. We ask how volunteer efforts are articulated and delineated through official accounts and discuss the implications of such an articulation and delineation. We seek answers to these questions through a critical discourse analysis of recent governmental white papers. We investigate, in other words, volunteer efforts as a political instrument. We argue that the official representation of how efforts in health and care services should be re-aligned take the form of a distinct discourse of ‘voluntarism’. Within this ‘voluntarism’, volunteer efforts have been altered from a third sector comprising charity and non-profit organisations that contribute within or as a supplement to the largely public-run welfare system to a limitless and extensive concept that is blurring the boundaries to informal care.
Leftward deviation of the primary septum or dividing left atrial shelf?
Authors: Hubrechts Jelena , Pollenus Julie , Gewillig Marc 
Published: November 2021

AbstractIsolated leftward prolapse or deviation of the primary atrial septum is a rare CHD that can mimic abnormal pulmonary venous return at first sight. We present a case of a newborn infant, referred for surgical correction of totally anomalous pulmonary venous return into the right atrium, with the peri-operative finding of a leftward deviation of the superior margin of the primary atrial septum. The distinction with a dividing atrial shelf could not be confirmed with certainty. Fifty-three similar cases from the literature are incorporated. A detailed review of the current account on atrial septation is studied. The embryological and clinical features of a dividing partition of the left atrium are discussed.
OBJECTIVE INTENTIONALISM AND DISAGREEMENT
Authors: Tan David 
Published: November 2021

AbstractIntentionalist theories of legal interpretation are often divided between objectivist and subjectivist variants. The former take an interpretation to be correct depending on what the reasonable/rational lawmaker intended or what the reasonable/rational audience thinks they intended. The latter take an interpretation to be correct where the interpretation is what the speaker actually intended. This paper argues that objectivism faces serious problems as it cannot deal with disagreement: reasonable and rational persons can often disagree as to what the interpretation of a text should be. It also defends subjectivism against criticisms by objectivists.
Investigating the role of spatial spillovers as determinants of land conversion in urbanizing Canada
Authors: Qiu Feng , Tong Qingmeng , Zhang Junbiao 
Published: November 2021

AbstractAlthough the impacts of income, population growth, and other important determinants of land-use change have been widely studied, there is less understanding of how spatial spillovers matter. Utilizing a spatial econometric approach, we investigate the main determinants of natural landscape conversion, focusing on quantifying local and global spatial spillovers. The empirical investigation applies to the Edmonton Metropolitan Region and the Calgary Regional Partnership in Canada. Key results include: (1) determinants of land conversion have significant spillover effects; (2) income, population density, road density, natural land endowment and land suitability for agriculture are all found to have influences on natural land conversion both in the own and neighboring areas; and (3) local (i.e., within the immediate neighboring areas) and global (in the entire study region) spillovers are different in strength and direction. Our work provides useful information for understanding the spillover issues in land conservation, resource governance, and optimal conservation design.
Analyzing Triassic and Permian Geomagnetic Paleosecular Variation and the Implications for Ancient Field Morphology
Authors: Handford B. T. , Biggin A. J. , Haldan M. M. , Langereis C. G. 
Published: November 2021

AbstractStudying paleosecular variation (PSV) can provide unique insights into the average morphology of the geomagnetic field and the operation of the geodynamo. Although recent studies have expanded our knowledge of paleomagnetic field behavior through the late Mesozoic, relatively little is known regarding the Triassic period (ca. 251.9–201.3 Ma). This study compiles the first Triassic virtual geomagnetic pole (VGP) database for the analysis of PSV, as part of a longer Post‐Permo‐Carboniferous Reversed Superchron (PCRS) time interval (265‐198 Ma). VGP angular dispersion and its dependence on apparent paleolatitude are compared against a new PCRS compilation and published PSV compilations for intervals across the last ∼320 Ma. We find that the Post‐PCRS displays near latitudinal invariance of VGP dispersion while the PCRS displays very strong latitudinal dependence. PSV behavior during the Post‐PCRS appears indistinguishable to that previously reported for the interval preceding the Cretaceous Normal Superchron (Pre‐CNS; 126–198 Ma). The near‐constant behavior between time intervals with significantly different apparent average polarity reversal frequencies does not support a suggested relationship between VGP dispersion and reversal frequency. The dispersion observed for the PCRS is consistent with the results of previous studies and represents behavior that is potentially unique over the last ∼320 Ma. A recently published approach to obtain a description of field morphology from equatorial VGP dispersion shows the PCRS geomagnetic field to have been more strongly axial dipole dominated than any interval since. This observation may be causally linked to the PCRS being the longest known superchron in the Phanerozoic geomagnetic polarity timescale.
Spring Dust in Western North America and Its Interannual Variability—Understanding the Role of Local and Transported Dust
Authors: Kim Dongchul , Chin Mian , Cruz Carlos A. , Tong Daniel , Yu Hongbin 
Published: November 2021

AbstractMineral dust over western North America is an important aerosol type contributing up to one half of surface aerosol concentrations in spring. In the present study, we use data from in‐situ and remote‐sensing observations and the NASA Unified WRF (NU‐WRF) model to investigate the sources and interannual variations of the springtime fine‐mode dust over western North America. The horizontal distribution, seasonality, and interannual variability of the springtime dust over the region are characterized with observations of fine dust concentrations at the Interagency Monitoring of Protected Visual Environments sites and dust optical depth from the Aerosol Robotic Network measurements. We have conducted detailed modeling and analysis for April in selected years of 2005, 2008, and 2009, to understand the causes of interannual variabilities of the springtime dust with model experiments that separate the dust generated from local deserts with that transported across the Pacific Ocean. The results suggest that although several permanent deserts and semi‐arid regions in western North America are the major source of surface fine dust concentrations in the immediate vicinity, long‐range transpacific transported dust is a dominant dust source in springtime, especially over the coastal regions and areas remote from the local deserts. Interannual variability of fine dust over western North America is explained with both local dust emission and long‐range transported dust.
Hydrodynamic‐Driven Changes in the Source and Composition of Sedimentary Organic Matter via Grain Size Distribution in Shallow Lakes
Authors: Xu Xiaoguang , Shi Ruijie , Lv Chengxu , Liu Huazu , Yang Wei , Qian Shenhua , Fujibayashi Megumu , Zhi Yue , Wang Guoxiang , Nomura Munehiro , Nishimura Osamu , Li Wei 
Published: November 2021

AbstractSediment organic matter (SOM) differs in composition and function in different size fractions in relation to material and energy flows. The hydrodynamic effects on a lake's autochthonous (terrestrial plants) and allochthonous (microalgae, aquatic plants, and bacteria) inputs and transformation, and the components of SOM are still far from clear. To elucidate the SOM composition as driven by the hydrodynamic conditions associated with sedimentary grain size, we performed an ecosystem‐level investigation in the shallow lake Izunuma, Japan, measuring source‐specific fatty acids and the current velocity. High organic matter concentrations occurred in the finer fractions. Bacteria were dominant in the <32 μm fraction, microalgae were mainly present in the <32 and 63–125 μm fractions, aquatic plants appeared to be evenly distributed in all size fractions, and terrestrial plants mainly comprised the >125 μm fraction. Although the linear correlation between current velocity and sedimentary total organic carbon (TOC) was not statistically significant, the relationship between current velocity frequency and sedimentary TOC was significant. The highest Pearson coefficient occurred at a current velocity of 6 cm/s in sand. The relationship between allochthonous inputs and current velocity frequency was similar to that of TOC. Autochthonous organics had the greatest coefficient with two peaks at 4.5 and 8 cm/s. The threshold for sand resuspension varied with organic sources, while this phenomenon was absent in cohesive mud. Hydrodynamic forces affected the grain size of sediments and drove the gradient distribution of the SOM sources, which should be considered when managing freshwater lakes in light of future climate change.
Risk factors for subjective cognitive decline: the CABLE study
Authors: Wen Chen , Hu Hao , Ou Ya-Nan , Bi Yan-Lin , Ma Ya-Hui , Tan Lan , Yu Jin-Tai 
Published: November 2021

AbstractIncreasing evidences supported that subjective cognitive decline (SCD) might be a potential first symptomatic manifestation of Alzheimer’s disease (AD). The rapidly growing number of SCD individuals who seek medical help and advice also makes it urgent to develop more precise strategy for SCD. Therefore, this study aimed to explore the risk factors for SCD. Logistics and linear regression models were performed to investigate 41 factors for SCD in 1165 participants without objective cognitive impairment. Cochran-Armitage trend test was used to confirm the constant trend toward higher prevalence of SCD with an increasing number of risk factors. A high overall prevalence of SCD was found in total participants (42%). Eight factors were eventually identified as risk factors for SCD, including four stable factors associated with both SCD statues and severity (older age, thyroid diseases, minimal anxiety symptoms, and day time dysfunction; odds ratio (OR) ranging from 1.74 to 2.29) as well as four suggestive factors associated with either SCD statues or severity (female sex, anemia, lack of physical exercises, and living alone; OR ranging from 1.30 to 2.29). The prevalence of SCD gradually increased with the number of risk factors clustering increased in individuals (p for trend <0.001). Five of these eight factors were further proved among individuals with SCD-plus features. These findings revealed several risk factors for SCD, providing some new clues for formulating priority strategies for early prevention of SCD.