bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ligamentum teres augmentation (LTA) for hiatal hernia repair after minimally invasive esophageal resection: a new use for an old structure
Authors: Runkel Mira , Kuvendjiska Jasmina , Marjanovic Goran , Fichtner-Feigl Stefan , Diener Markus K. 
Published: October 2021

Abstract
Purpose
Hiatal hernias with intrathoracic migration of the intestines are serious complications after minimally invasive esophageal resection with gastric sleeve conduit. High recurrence rates have been reported for standard suture hiatoplasties. Additional mesh reinforcement is not generally recommended due to the serious risk of endangering the gastric sleeve. We propose a safe, simple, and effective method to close the hiatal defect with the ligamentum teres.

Methods
After laparoscopic repositioning the migrated intestines, the ligamentum teres is dissected from the ligamentum falciforme and the anterior abdominal wall. It is then positioned behind the left lobe of the liver and swung toward the hiatal orifice. Across the anterior aspect of the hiatal defect it is semi-circularly fixated with non-absorbable sutures. Care should be taken not to endanger the blood supply of the gastric sleeve.

Results
We have used this technique for a total of 6 patients with hiatal hernias after hybrid minimally invasive esophageal resection in the elective (n = 4) and emergency setting (n = 2). No intraoperative or postoperative complications have been observed. No recurrence has been reported for 3 patients after 3 months.

Conclusion
Primary suture hiatoplasties for hiatal hernias after minimally invasive esophageal resection can be technically challenging, and high postoperative recurrence rates are reported. An alternative, safe method is needed to close the hiatal defect. Our promising preliminary experience should stimulate further studies regarding the durability and efficacy of using the ligamentum teres hepatis to cover the hiatal defect.
Human cytomegalovirus multiple-strain infections and viral population diversity in haematopoietic stem cell transplant recipients analysed by high-throughput sequencing
Authors: Dhingra A. , Götting J. , Varanasi P. R. , Steinbrueck L. , Camiolo S. , Zischke J. , Heim A. , Schulz T. F. , Weissinger E. M. , Kay-Fedorov P. C. , Davison A. J. , Suárez N. M. , Ganzenmueller T. 
Published: October 2021

AbstractHuman cytomegalovirus (HCMV) is an important opportunistic pathogen in allogeneic haematopoietic stem cell transplant (HSCT) recipients. High-throughput sequencing of target-enriched libraries was performed to characterise the diversity of HCMV strains present in this high-risk group. Forty-four HCMV-DNA-positive plasma specimens (median viral input load 321 IU per library) collected at defined time points from 23 HSCT recipients within 80 days of transplantation were sequenced. The genotype distribution for 12 hypervariable HCMV genes and the number of HCMV strains present (i.e. single- vs. multiple-strain infection) were determined for 29 samples from 16 recipients. Multiple-strain infection was observed in seven of these 16 recipients, and five of these seven recipients had the donor (D)/recipient (R) HCMV-serostatus combination D + R + . A very broad range of genotypes was detected, with an intrahost composition that was generally stable over time. Multiple-strain infection was not associated with particular virological or clinical features, such as altered levels or duration of antigenaemia, development of acute graft-versus-host disease or increased mortality. In conclusion, despite relatively low viral plasma loads, a high frequency of multiple-strain HCMV infection and a high strain complexity were demonstrated in systematically collected clinical samples from this cohort early after HSCT. However, robust evaluation of the pathogenic role of intrahost viral diversity and multiple-strain infection will require studies enrolling larger numbers of recipients.
Automated constitutive modeling of isotropic hyperelasticity based on artificial neural networks
Authors: Kalina Karl A. , Linden Lennart , Brummund Jörg , Metsch Philipp , Kästner Markus 
Published: October 2021

AbstractHerein, an artificial neural network (ANN)-based approach for the efficient automated modeling and simulation of isotropic hyperelastic solids is presented. Starting from a large data set comprising deformations and corresponding stresses, a simple, physically based reduction of the problem’s dimensionality is performed in a data processing step. More specifically, three deformation type invariants serve as the input instead of the deformation tensor itself. In the same way, three corresponding stress coefficients replace the stress tensor in the output layer. These initially unknown values are calculated from a linear least square optimization problem for each data tuple. Using the reduced data set, an ANN-based constitutive model is trained by using standard machine learning methods. Furthermore, in order to ensure thermodynamic consistency, the previously trained network is modified by constructing a pseudo-potential within an integration step and a subsequent derivation which leads to a further ANN-based model. In the second part of this work, the proposed method is exemplarily used for the description of a highly nonlinear Ogden type material. Thereby, the necessary data set is collected from virtual experiments of discs with holes in pure plane stress modes, where influences of different loading types and specimen geometries on the resulting data sets are investigated. Afterwards, the collected data are used for the ANN training within the reduced data space, whereby an excellent approximation quality could be achieved with only one hidden layer comprising a low number of neurons. Finally, the application of the trained constitutive ANN for the simulation of two three-dimensional samples is shown. Thereby, a rather high accuracy could be achieved, although the occurring stresses are fully three-dimensional whereas the training data are taken from pure two-dimensional plane stress states.
The impact of rest breaks on subjective fatigue in physicians of the General Hospital of Vienna
Authors: Blasche Gerhard , Arlinghaus Anna , Crevenna Richard 
Published: October 2021

Summary
Aims
Medical doctors are affected by high levels of occupational burnout. Work organization such as sufficient rest breaks can decrease stress and fatigue; however, rest breaks are often skipped under high workload and time pressure. The present study sought to investigate the effect of self-determined rest breaks on acute and daily levels of fatigue in physicians of the General Hospital of Vienna.

Methods
Rest breaks and fatigue were recorded throughout day shifts over a time span of 4 weeks with a mobile assessment device. A total of 12 physicians of a university clinic participated in the study. Data were analyzed using generalized estimating equations.

Results
Analyses were based on a total of 115 workdays including 93 rest breaks and 800 fatigue assessments. Physicians took an average of 0.81 rest breaks per day. Fatigue was lower in the 30 min after the break than in the hour before the break; however, the number of rest breaks did not affect the increase of fatigue during shifts.

Conclusion
Self-determined rest breaks were effective in reducing acute fatigue in hospital physicians during work. The failure to find an effect on the increase of work-related fatigue may be due to the infrequency of rest breaks in hospital physicians.
The influence of spinal position on imaging findings: an observational study of thoracolumbar spine upright MRI in elite gymnasts
Authors: Fawcett Louise , James Steven , Botchu Rajesh , Martin James , Heneghan Nicola R. , Rushton Alison 
Published: October 2021

Abstract
Purpose
To investigate whether upright magnetic resonance imaging (MRI) has a role in defining thoracolumbar spine pathology in elite gymnastics.

Methods
A prospective cross-sectional observational study of National Senior and Junior Artistic gymnasts in three MRI positions (standard supine, upright flexed and extended positions). Two specialist musculoskeletal radiologists independently analysed images with neutral as a baseline with the effects of flexion and extension reported in line with Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement.

Results
Forty (18 males) gymnasts aged 13–24 years with a mean (SD) of 32 (5.3) training hours per week consented with 75% showing MRI abnormalities. Degenerative disc disease (DDD) was evident in 55% participants with vertebral end plate (VEP) changes in 42.5%. Spondylolysis was present in 40% with an additional 17% showing chronic bilateral complete L5 pars defects. 23% participants demonstrated different MRI findings in upright flexion compared to neutral.

Conclusion
Findings suggest a high levels of MRI abnormalities in elite gymnastics including altered disc morphology and posterior element abnormalities. High prevalence of T11/12 DDD and VEP changes reflects the thoracolumbar junction being a transition zone. Upright MRI and varying spine position offer promise for enhanced visualisation of posterior element abnormalities.
Dual orexin receptor antagonists for insomnia in youth with neurodevelopmental disorders: a case series and review
Authors: Besterman Aaron D. , Jeste Shafali S. 
Published: October 2021

AbstractInsomnia is a common, impairing, and difficult-to-treat comorbidity in children with neurodevelopmental disorders (NDDs). Behavioral interventions can be challenging because of developmental and behavioral features that interfere with treatment. Medication management also can be difficult due to a high burden of side effects, a high rate of paradoxical responses, and frequent treatment resistance. Therefore, new treatment options for insomnia in children with NDDs are needed. Dual orexin receptor antagonists (DORAs) are a relatively new class of pharmacotherapeutics that induce sleep by inhibiting the orexin signaling pathway. To date, there is little safety or efficacy data on the use of DORAs in children with NDDs. We present four patients with NDDs and insomnia that we treated with the DORA, suvorexant. We found that patients had a wide range of responses, with one patient displaying a robust improvement in sleep onset and maintenance, while another had significant improvement in insomnia symptoms on combination therapy with trazodone. Our final two patients had mild or no benefit from suvorexant therapy. Further research is necessary to establish the safety and efficacy of DORAs in this population and to identify predictive factors, such as specific neurogenetic diagnoses or clinical features, of a positive treatment response.
The effects of psychological treatments of depression in children and adolescents on response, reliable change, and deterioration: a systematic review and meta-analysis
Authors: Cuijpers Pim , Karyotaki Eirini , Ciharova Marketa , Miguel Clara , Noma Hisashi , Stikkelbroek Yvonne , Weisz John R. , Furukawa Toshi A. 
Published: October 2021

AbstractMeta-analyses show that psychotherapies are effective in the treatment of depression in children and adolescents. However, these effects are usually reported in terms of effect sizes. For patients and clinicians, it is important to know whether patients achieve a clinically significant improvement or deterioration. We conducted such a meta-analysis to examine response, clinically significant change, clinically significant deterioration and recovery as outcomes. We searched four bibliographic databases and included 40 randomised trials comparing psychotherapy for youth depression against control conditions. We used a validated method to estimate outcome rates, based on means, standard deviation and N at baseline and post-test. We also calculated numbers-need-to- treat (NNT). The overall response rate in psychotherapies at 2 (±1) months after baseline was 39% (95% CI: 34–45) and 24% (95% CI: 0.19–28) in control conditions (NNT: 6.2). The difference between therapy and control was still significant at 6–12 months after baseline (NNT=7.8). Clinically significant improvement was found in 54% of youth in therapy, compared with 32% in control groups (NNT=5.3); clinically significant deterioration was 6% in therapy, 13% in controls (NNT=5.1); recovery was 58% in therapy, 36% in controls (NNT=3.3). Smaller effects were found in studies with low risk of bias. Psychotherapies for depression in youth are effective compared to control conditions, but more than 60% of youth receiving therapy do not respond. More effective treatments and treatment strategies are clearly needed. Trial registrationhttps://osf.io/84xka
Characterising thermal water circulation in fractured bedrock using a multidisciplinary approach: a case study of St. Gorman’s Well, Ireland
Authors: Blake Sarah , Henry Tiernan , Moore John Paul , Murray John , Campanyà Joan , Muller Mark R. , Jones Alan G. , Rath Volker , Walsh John 
Published: October 2021

AbstractA hydrogeological conceptual model of the source, circulation pathways and temporal variation of a low-enthalpy thermal spring in a fractured limestone setting is derived from a multidisciplinary approach. St. Gorman’s Well is a thermal spring in east-central Ireland with a complex and variable temperature profile (maximum of 21.8 °C). Geophysical data from a three-dimensional(3D)audio-magnetotelluric(AMT) survey are combined with time-lapse hydrogeological data and information from a previously published hydrochemical analysis to investigate the operation of this intriguing hydrothermal system. Hydrochemical analysis and time-lapse measurements suggest that the thermal waters flow within the fractured limestones of the Carboniferous Dublin Basin at all times but display variability in discharge and temperature. The 3D electrical resistivity model of the subsurface revealed two prominent structures: (1) a NW-aligned faulted contact between two limestone lithologies; and (2) a dissolutionally enhanced, N-aligned, fault of probable Cenozoic age. The intersection of these two structures, which has allowed for karstification of the limestone bedrock, has created conduits facilitating the operation of relatively deep hydrothermal circulation (likely estimated depths between 240 and 1,000 m) within the limestone succession of the Dublin Basin. The results of this study support a hypothesis that the maximum temperature and simultaneous increased discharge observed at St. Gorman’s Well each winter is the result of rapid infiltration, heating and recirculation of meteoric waters within a structurally controlled hydrothermal circulation system.
Prognostic significance of receptor expression discordance between primary and recurrent breast cancers: a meta-analysis
Authors: Shiino Sho , Ball Graham , Syed Binafsha M. , Kurozumi Sasagu , Green Andrew R. , Tsuda Hitoshi , Takayama Shin , Suto Akihiko , Rakha Emad A. 
Published: October 2021

Abstract
Purpose
This meta-analysis aimed to investigate whether receptor (estrogen receptor [ER], progesterone receptor [PR], and human epidermal growth factor receptor 2 [HER2]) discordances between primary and recurrent breast cancers affect patients’ survival.

Methods
Search terms contained ER, PR, and HER2 status details in both primary and recurrent tumors (local recurrence or distant metastasis) in addition to survival outcome data (overall survival [OS] or post-recurrence survival [PRS]).

Results
Loss of ER or PR in recurrent tumors was significantly associated with shorter OS as compared with receptor-positive concordance (hazard ratio [HR], 1.67; 95% confidence interval [% CI] 1.37–2.04; p < 0.00001 and HR, 1.45; 95% CI 1.21–1.75; p < 0.0001, respectively). Similar trends were observed in groups with only distant metastasis. Gain of ER was a significant predictor of longer PRS as compared with receptor-negative concordance (HR, 0.76; 95% CI 0.59–0.97; p = 0.03). Gain of PR was not a significant predictor of longer survival compared with receptor-negative concordance, but it could be related to better OS at distant metastasis. Both HER2 of loss and gain could be related to poor outcomes.

Conclusion
This meta-analysis showed that receptor conversion in recurrent tumors may affect patient survival as compared with receptor concordance.
Development of a Model for Predicting the Volatilization Flux from Unsaturated Soil Contaminated by Volatile Chemical Substances
Authors: Kondo Monami , Sakamoto Yasuhide , Kawabe Yoshishige , Nakamura Kengo , Watanabe Noriaki , Komai Takeshi 
Published: October 2021

AbstractThis work developed a model for predicting the volatilization flux from the unsaturated soil contaminated by volatile chemical substances (VCSs) such as mercury and benzene. The model considers a series of phenomena under the unsaturated condition such as multi-phase flow consisting of a non-aqueous phase liquid, water, and gases together with the permeation of rainfall into the surface soil, the volatilization/condensation of VCSs, and the adsorption/desorption of VCSs. On this basis, this work clarified a mechanism for the generation of a volatilization flux at the ground surface. In addition, the effects of various transport phenomena in the surface soil on the magnitude and seasonal changes in this flux due to variations in weather factors such as rainfall level, temperature, and air pressure were quantitatively evaluated. This newly developed prediction model can be utilized to estimate dynamic variations in the flux under real-environmental conditions.
Brief Report: The Broad Autism Phenotype in Swedish Parents of Children With and Without Autism Spectrum Conditions
Authors: Bang Peter , Strömberg Maria , Meera Shoba S. , Igelström Kajsa 
Published: October 2021

AbstractThe broad autism phenotype (BAP) is a set of characteristics often observed in typically developing people with a genetic load for autism, such as parents of autistic children. The Broad Autism Phenotypic Questionnaire (BAPQ) is a 36-item questionnaire developed to identify the BAP in first-degree relatives of autistic people. We translated the BAPQ into Swedish and examined its psychometric properties in a Swedish sample consisting of 45 parents of children with ASC and 74 parents of non-autistic children. We found support for the original 3-factor structure (aloof, pragmatic language and rigid), good internal consistency and convergent validity with the Autism Quotient. Thus, the Swedish BAPQ exhibits acceptable psychometric properties and may be useful for assessing the BAP in non-clinical populations.
Enhancing the stability and crystallinity of CsPbIBr2 through antisolvent engineering
Authors: Stewart Alexander W. , Bouich Amal , Soucase Bernabé Marí 
Published: October 2021

AbstractAll inorganic lead-based perovskites containing bromine-iodine alloys, such as CsPbIBr2, have arisen as one of the most attractive candidates for absorber layers in solar cells. That said, there remains a large gap when it comes to film and crystal quality between the inorganic and hybrid perovskites. In this work, antisolvent engineering is employed as a simple and reproducible method for improving CsPbIBr2 thin films. We found that both the antisolvent used and the conditions under which it was applied have a measurable impact on both the quality and stability of the final product. We arrived at this conclusion by characterising the samples using scanning electron microscopy, X-ray diffraction, UV–visible and photoluminescence measurements, as well as employing a novel system to quantify stability. Our findings, and the application of our novel method for quantifying stability, demonstrate the ability to significantly enhance CsPbIBr2 samples, produced via a static one-step spin coating method, by applying isopropanol 10 s after commencing the spin programme. The antisolvent quenched CsPbIBr2 films demonstrate both improved crystallinity and an extended lifespan.
Effects of Income and Material Deprivation on Children’s Life Satisfaction: Evidence from Longitudinal Data for England (2009–2018)
Authors: Knies Gundi 
Published: October 2021

AbstractA plethora of research shows that income is an important factor in adult’s life satisfaction, but research ascertaining its importance for children’s life satisfaction is scant. Using a largescale nationally representative longitudinal survey with children aged 10–15, we estimate comprehensive life satisfaction models that account for heterogeneity in exogenous circumstances in children’s lives, focussing on family income and material deprivation. We find empirical support for the hypothesis that children are more satisfied with their lives, the more income their family has and the less material deprivation they experience throughout their teens. There are, however, differences across age groups with children aged 12–15 experiencing greater life satisfaction losses on account of lower family material wellbeing than younger children. Overall, income effects for older children are small but statistically significant when accounting for unobserved individual differences.
Long-Term Effects of Acceptance and Rejection by Parents and Peers on Educational Attainment: A Study from Pre-Adolescence to Early Adulthood
Authors: Lorijn Sofie J. , Engels Maaike C. , Huisman Mark , Veenstra René 
Published: October 2021

AbstractAcceptance and rejection by parents and peers play an important role in pre-adolescents’ educational outcomes. Prior research focused on either parents or peers, did not encompass effects into adulthood, or considered either acceptance or rejection. This study investigated the relation between parental and peer acceptance and rejection, and their interplay, in pre-adolescence and educational attainment in early adulthood. A sample of 2229 pre-adolescents (MageT1 = 11.11, SD = 0.56; 50.7% girls) was followed to early adulthood (MageT5 = 22.29, SD = 0.65). Ordinal logistic regression showed that pre-adolescents’ perceived parental acceptance was positively related to educational attainment in early adulthood, whereas peer rejection was negatively related, even when WISC score and socioeconomic status were considered. No interaction effects were found, revealing no “dual-hit effect” of being rejected by parents and peers, no “dual-miss effect” of being accepted by parents and peers, and no effects of acceptance in one context (i.e., parents or peers) buffering the negative effect of rejection in the other context. The findings underscore unique and long-term links of parental acceptance and peer rejection with early adults’ educational attainment, underlining the importance of not only peers but also parents in adolescence. These insights can be used in promoting long-term educational outcomes through relationships with parents and peers.
Understanding and explanation. Paul Ricœur and human geography
Authors: Furia Paolo 
Published: October 2021

AbstractThe aim of my paper is to put Ricœur’s philosophy in dialogue with human geography. There are at least two good reasons to do so. The first concerns the epistemological foundation of geography: Whereas humanistic or phenomenological geographers inspired by Heidegger or, to a lesser extent, by Merleau-Ponty have sometimes taken on an anti-scientific approach, the Ricœurian articulation of understanding and explanation may contribute to building a bridge between the experiential side of place-meanings and the scientific explanations of spatial elements and their relationships. The second reason has to do with the application of the Ricœurian “model of the text” to landscape: It is a direction that Ricœur never explicitly took, but it is worth exploring, especially considering that “landscape as a text” was quite a popular metaphor among human geographers in the 1980s and 1990s. In this paper I will discuss both issues in order to outline a “Ricœurian path to geography,” which, while never explicitly developed by the philosopher, may represent an innovative and fruitful actualization of his thought.