bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendations for diagnosing STIC: a systematic review and meta-analysis
Authors: Bogaerts Joep M. A. , Steenbeek Miranda P. , van Bommel Majke H. D. , Bulten Johan , van der Laak Jeroen A. W. M. , de Hullu Joanne A. , Simons Michiel 
Published: December 2021

AbstractOur understanding of the oncogenesis of high-grade serous cancer of the ovary and its precursor lesions, such as serous tubal intraepithelial carcinoma (STIC), has significantly increased over the last decades. Adequate and reproducible diagnosis of these precursor lesions is important. Diagnosing STIC can have prognostic consequences and is an absolute requirement for safely offering alternative risk reducing strategies, such as risk reducing salpingectomy with delayed oophorectomy. However, diagnosing STIC is a challenging task, possessing only moderate reproducibility. In this review and meta-analysis, we look at how pathologists come to a diagnosis of STIC. We performed a literature search identifying 39 studies on risk reducing salpingo-oophorectomy in women with a known BRCA1/2 PV, collectively reporting on 6833 patients. We found a pooled estimated proportion of STIC of 2.8% (95% CI, 2.0–3.7). We focused on reported grossing protocols, morphological criteria, level of pathologist training, and the use of immunohistochemistry. The most commonly mentioned morphological characteristics of STIC are (1) loss of cell polarity, (2) nuclear pleomorphism, (3) high nuclear to cytoplasmic ratio, (4) mitotic activity, (5) pseudostratification, and (6) prominent nucleoli. The difference in reported incidence of STIC between studies who totally embedded all specimens and those who did not was 3.2% (95% CI, 2.3–4.2) versus 1.7% (95% CI, 0.0–6.2) (p 0.24). We provide an overview of diagnostic features and present a framework for arriving at an adequate diagnosis, consisting of the use of the SEE-FIM grossing protocol, evaluation by a subspecialized gynecopathologist, rational use of immunohistochemical staining, and obtaining a second opinion from a colleague.
Gregarines modulate insect responses to sublethal insecticide residues
Authors: Wolz Marina , Schrader Alia , Whitelaw Eileen , Müller Caroline 
Published: December 2021

AbstractThroughout their lifetime, insects face multiple environmental challenges that influence their performance. Gregarines are prevalent endoparasites in most invertebrates that affect the fitness of their hosts, but are often overlooked in ecological studies. Next to such biotic factors, a current common challenge is anthropogenic pollution with pesticides, which causes a major threat to non-target organisms that are readily exposed to lethal or sublethal concentrations. In a laboratory study, we investigated whether the presence of gregarines modulates the food consumption and life history traits of a (non-target) leaf beetle species, Phaedon cochleariae, in response to sublethal insecticide exposure. We show that the larval food consumption of the herbivore was neither affected by gregarine infection nor sublethal insecticide exposure. Nevertheless, infection with gregarines led to a delayed development, while insecticide exposure resulted in a lower body mass of adult males and a reduced reproduction of females. Individuals exposed to both challenges suffered most, as they had the lowest survival probability. This indicates detrimental effects on the population dynamics of non-target insects infected with naturally occurring gregarines that face additional stress from agrochemical pollution. Moreover, we found that the infection load with gregarines was higher in individuals exposed to sublethal insecticide concentrations compared to unexposed individuals. To counteract the global decline of insects, the potential of natural parasite infections in modulating insect responses to anthropogenic and non-anthropogenic environmental factors should be considered in ecological risk assessment.
Desaster Szenario unter Tage – MED1stMR – neue Ansätze im Training von medizinischen Ersthelfern
Authors: Harthum Birgit , Schrom-Feiertag Helmut , Wenighofer Robert 
Published: December 2021

ZusammenfassungMedizinische Ersthelfer adäquat und realitätsnahe zu trainieren, ist eine Herausforderung. Realistische Umgebungen, die zu Übungszwecken gesperrt werden können, sind rar gesät und werden oftmals aufgrund von Budget und zeitlichen Einschränkungen selten genutzt. Das Zentrum am Berg (ZaB) der Montanuniversität Leoben, Österreich, hat hierzu bereits 2019 Lösungsansätze entwickelt, die das Training von Blaulichtorganisationen auch in unter Tage Situationen ermöglichen. Die Errichtung von Testzentren wie dem ZaB-Projekt folgt dem Vorschlag der EU-Kommission, die Sicherheit von Straßen- und Eisenbahntunneln zu erhöhen, und ist eine Reaktion auf die mehreren Tausend Tunnelkilometer in der EU, die in Betrieb oder im Bau sind.Mit der Teilnahme des ZaB am Forschungsprojekt MED1stMR wird ein weiterer Schritt in die Verbesserung solcher medizinischen Einsatztrainings unternommen. Nun soll nicht mehr nur im realen Umfeld trainiert werden können, sondern die Erfahrung aus dem Tunnel und seine Besonderheiten für Ersthelfer wandert in die erweiterte virtuelle Umgebung und es soll ein Trainingslösung entstehen, die Virtual Reality (VR) mit haptischen Objekten wie Simulationspuppen und der Messung von Stressdaten der Ersthelfer zu einer Mixed Reality (MR) Lösung vereint, um eine auf künstlicher Intelligenz basierte Szenario Steuerung zu implementieren, um letztlich die Leistung der medizinischen Ersthelfer unter Wahrung ihrer Resilienz zu steigern. MED1stMR Train – [Skills.Resilience.Performance] – Save Lives ist hierzu das Motto des EU geförderten Forschungs-Projektes.
Leitlinie S1: Long COVID: Differenzialdiagnostik und Behandlungsstrategien
Authors: Rabady Susanne , Altenberger Johann , Brose Markus , Denk-Linnert Doris-Maria , Fertl Elisabeth , Götzinger Florian , de la Cruz Gomez Pellin Maria , Hofbaur Benedikt , Hoffmann Kathryn , Hoffmann-Dorninger Renate , Koczulla Rembert , Lammel Oliver , Lamprecht Bernd , Löffler-Ragg Judith , Müller Christian A. , Poggenburg Stefanie , Rittmannsberger Hans , Sator Paul , Strenger Volker , Vonbank Karin , Wancata Johannes , Weber Thomas , Weber Jörg , Weiss Günter , Wendler Maria , Zwick Ralf-Harun 
Published: December 2021

ZusammenfassungDie vorliegende Leitlinie S1 fasst den Stand der Kenntnis zu Long COVID zum Zeitpunkt des Redaktionsschlusses zusammen. Aufgund der starken Dynamik der Wissensentwicklung versteht sie sich als „living guideline“. Der Schwerpunkt liegt auf der praktischen Anwendbarkeit auf der Ebene der hausärztlichen Primärversorgung, die als geeignete Stelle für den Erstzutritt und für die primäre Betreuung und Behandlung verstanden wird. Die Leitlinie gibt Empfehlungen zur Differenzialdiagnostik der häufigsten Symptome, die in der Folge einer Infektion mit SARS-CoV‑2 auftreten können, zu therapeutischen Optionen, zu Patient:innenführung und -betreuung, sowie zu Wiedereingliederung in den Alltag, und die Rehabilitation. Entsprechend des Krankheitsbildes ist die Leitlinie in einem interdisziplinären Prozess entstanden und gibt Empfehlungen zu Schnittstellen und Kooperationsmöglichkeiten.
Evaluation of visual-induced motion sickness from head-mounted display using heartbeat evoked potential: a cognitive load-focused approach
Authors: Park Sangin , Kim Laehyun , Kwon Jangho , Choi Soo Ji , Whang Mincheol 
Published: December 2021

AbstractBased on sensory conflict theory, motion sickness is strongly related to the information processing capacity or resources of the brain to cope with the multi-sensory stimuli experienced by watching virtual reality (VR) content. The purpose of this research was to develop a method of measuring motion sickness using the heart-evoked potential (HEP) phenomenon and propose new indicators for evaluating motion sickness. Twenty-eight undergraduate volunteers of both genders (14 females) participated in this study by watching VR content on both 2D and head-mounted devices (HMD) for 15 min. The responses of HEP measures such as alpha power, latency, and amplitude of first and second HEP components were compared using paired t-tests and ANCOVA. This study confirmed that motion sickness leads to a decline in cognitive processing, as demonstrated by increasing in alpha power of HEP. Also, the proposed indicators such as latency and amplitude of the HEP waveform showed significant differences during the experience of motion sickness and exhibited high correlations with alpha power measures. Latencies of the first HEP component, in particular, are recommended as better quantitative evaluators of motion sickness than other measures, following the multitrait-multimethod matrix. The proposed model for motion sickness was implemented in a support vector machine with a radial basis function kernel, and validated on twenty new participants. The accuracy, F1 score, precision, recall, and area under the curve (AUC) of the motion-sickness classification results were 0.875, 0.865, 0.941, 0.8, and 0.962, respectively.
Metal accumulation in relation to size and body condition in an all-alien species community
Authors: Balzani Paride , Kouba Antonín , Tricarico Elena , Kourantidou Melina , Haubrock Phillip J. 
Published: December 2021

AbstractMetal pollution is one of the main environmental threats in freshwater ecosystems. Aquatic animals can accumulate these substances and transfer them across the food web, posing risks for both predators and humans. Accumulation patterns strongly vary depending on the location, species, and size (which in fish and crayfish is related to age) of individuals. Moreover, high metal concentrations can negatively affect animals’ health. To assess the intraspecific relationship between metal accumulation and size and health (proxied by the body condition) of individuals, the concentration of 14 metals (Al, As, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Ni, Pb, Se, Zn) was analyzed in six alien species from the highly anthropogenically altered Arno River (Central Italy): five fish (Alburnus alburnus, Pseudorasbora parva, Lepomis gibbosus, Ictalurus punctatus, and Silurus glanis) and one crayfish (Procambarus clarkii). We found that in P. clarkii, Cu was negatively related to size, as well as Al in L. gibbosus and Mg for adult I. punctatus. Positive size-dependent relationships were found for Hg in L. gibbosus, Fe in S. glanis, and Cr in juvenile I. punctatus. Only Co and Mg in S. glanis were found to negatively correlate with individual health. Since metal concentrations in animal tissue depend on trade-offs between uptake and excretion, the few significant results suggest different types of trade-offs across different species and age classes. However, only predatory fish species (L. gibbosus, I. punctatus, and S. glanis) presented significant relationships, suggesting that feeding habits are one of the primary drivers of metal accumulation.
Tissue distribution and transcriptional regulation of CCN5 in the heart after myocardial infarction
Authors: Zolfaghari Sima , Kaasbøll Ole Jørgen , Ahmed M. Shakil , Line Fabian A. , Hagelin Else Marie V. , Monsen Vivi T. , Attramadal Håvard 
Published: December 2021

AbstractCCN5 is a divergent member of the cellular communication network factor (CCN) family in that it lacks the carboxyl terminal cystine knot domain common to the other CCN family members. CCN5 has been reported to antagonize the profibrotic actions of CCN2 and to inhibit myocardial collagen deposition and fibrosis in chronic pressure overload of the heart. However, what mechanisms that regulate CCN5 activity in the heart remain unknown. Recombinant, replication defective adenovirus encoding firefly luciferase under control of the human CCN5 promoter was prepared and used to investigate what mechanisms regulate CCN5 transcription in relevant cells. Tissue distribution of CCN5 in hearts from healthy mice and from mice subjected to myocardial infarction was investigated. Contrary to the profibrotic immediate early gene CCN2, we find that CCN5 is induced in the late proliferation and maturation phases of scar healing. CCN5 was identified principally in endothelial cells, fibroblasts, smooth muscle cells, and macrophages. Our data show that CCN5 gene transcription and protein levels are induced by catecholamines via β2-adrenergic receptors. Myocardial induction of CCN5 was further confirmed in isoproterenol-infused mice. We also find that CCN5 transcription is repressed by TNF-α, an inflammatory mediator highly elevated in early phases of wound healing following myocardial infarction. In conclusion, CCN5 predominates in endothelial cells, fibroblasts, and macrophages of the differentiating scar tissue and its transcription is conversely regulated by β2-adrenergic agonists and TNF-α.
Preliminary results of a vaginal constraint for reducing G2 late vaginal complications after postoperative brachytherapy in endometrial cancer: a prospective analysis
Authors: Zhang Y. , Gomez G. , Ascaso C. , Herreros A. , Fornes B. , Mases J. , Rochera J. , Tagliaferri L. , Sabater S. , Torne A. , Biete A. , Rovirosa Á. 
Published: December 2021

Abstract
Purpose
To evaluate the preliminary results of the use of 68 Gy EQD2(α/β=3 Gy) as a dose limit to the lowest dose in the most exposed 2 cm3 of the vagina in order to reduce G2 late vaginal problems in postoperative endometrial carcinoma (EC).

Methods
From November 2016 to October 2019, 69 postoperative EC patients receiving vaginal brachytherapy (VBT) ± external beam radiotherapy (EBRT) were prospectively analyzed. The median EBRT dose was 45 Gy (range: 44–50.4 Gy), 1.8−2 Gy/day, 5 fractions(Fr)/week. VBT was administered with the following schedule: 1Fr of 7 Gy after EBRT and 2 daily Fr × 7.5 Gy in exclusive VBT. The dose was prescribed at 0.5 cm from the applicator surface with an active length of 2.5 cm; 56 patients were treated with vaginal cylinders (49–3.5 cm, 6–3 cm, and 1–2.5 cm) and 13 with the colpostat technique. The overall VBT dose was adjusted to meet the vaginal restriction of < 68 Gy EQD2(α/β=3 Gy) at 2 cm3. Late toxicity was prospectively assessed using RTOG scores for bladder and rectum, and the objective LENT-SOMA criteria for vagina.

Results
With a median follow-up of 31.0 months, no vaginal-cuff recurrences were found. Late toxicity: only 1G1(1.4%) rectal toxicity; 21G1(30.4%) and 3G2(4.3%) vaginal complications. Only one (1.4%) of 3 G2 manifested as vaginal shortening.

Conclusions
In postoperative EC patients treated with VBT, only one developed G2 vaginal stenosis with the use of 68 Gy EQD2(α/β=3 Gy) as a dose constraint. These preliminary results seem to indicate the value of this dose limit for reducing G2 vaginal stenosis. Nonetheless, these findings should be confirmed in a larger number of patients with longer follow-up.
Silicon Seed Priming Combined with Foliar Spray of Sulfur Regulates Photosynthetic and Antioxidant Systems to Confer Drought Tolerance in Maize (Zea mays L.)
Authors: Farman Muhammad , Nawaz Fahim , Majeed Sadia , Javeed Hafiz Muhammad Rashad , Ahsan Muhammad , Ahmad Khawaja Shafique , Aurangzaib Muhammad , Bukhari Muhammad Adnan , Shehzad Muhammad Asif , Hussain Muhammad Baqir 
Published: December 2021

AbstractThe present study evaluated the effect of silicon (Si) seed priming and sulfur (S) foliar spray on drought tolerance of two contrasting maize hybrids viz. drought tolerant Hi-Corn 11 and susceptible P-1574. The maize seeds were primed with (3 mM Na2SiO3) or without Si (hydropriming) and later sown in pots filled with sandy loam soil. Drought stress (25–30% water holding capacity or WHC) was initiated at cob development stage (V5) for two weeks, whereas the well-watered plants were grown at 65–70% WHC. On appearance of drought symptoms, foliar spray of S was done using 0.5% and 1.0% (NH4)2SO4, whereas water spray was used as a control. The drought-stressed plants were grown for further two weeks at 25–30% WHC before the final harvest. The results showed a marked effect of Si seed priming and foliar S spray on biomass, physiological and enzymatic processes as well as macronutrient concentrations of maize. In comparison to control, the highest increase in leaf relative water content (25%), chlorophyll a content (56%), carotenoids (26%), photosynthetic rate (64%), stomatal conductance (56%) and intercellular CO2 concentration (48%) was observed by Si seed priming + S foliar spray (Si + S) under water deficit conditions. Also, Si + S application stimulated the activity of catalase (45%), guaiacol peroxidase (38%) and superoxide dismutase (55%), and improved NPK concentrations (40–63%) under water limitations. Our results suggest that Si seed priming + foliar spray of S is more effective than the individual application of these nutrients to enhance drought tolerance in maize.
Mitophagy in carcinogenesis and cancer treatment
Authors: Denisenko Tatiana V. , Gogvadze Vladimir , Zhivotovsky Boris 
Published: December 2021

AbstractIn order to maintain a functional mitochondrial network, cells have developed a quality control mechanism, namely mitophagy. This process can be induced through different pathways. The most studied is the so-called PINK1/Parkin pathway, which is associated with ubiquitylation of several mitochondrial proteins that were initially found to be related to Parkinson’s disease. Another type of mitophagy is known as receptor-mediated mitophagy, which includes proteins, such as BNIP3 and BNIP3L, also known as Nix. Through these two mechanisms, mitophagy fulfills its functions and maintains cellular homeostasis. Here, we summarize the current knowledge about the mechanisms of mitophagy regulation and their interplay with cancer progression as well as anticancer treatment.
Student and faculty perceptions of, and experiences with, academic dishonesty at a medium-sized Canadian university
Authors: Awosoga Oluwagbohunmi , Nord Christina M. , Varsanyi Stephanie , Barley Randall , Meadows Jeff 
Published: December 2021

AbstractThere is a paucity of research into the prevalence of academic dishonesty within Canada compared to other countries. Recently, there has been a call for a better understanding of the particular characteristics of educational integrity in Canada so that Canada can more meaningfully contribute to current discussions surrounding academic integrity. Here, we present findings from student (N = 1142) and faculty (N = 130) surveys conducted within a medium-sized (~ 8700 students) Canadian university. These surveys probed perceptions towards, and experiences with, academic dishonesty, in which we aimed to understand how students and faculty regarded academically dishonest practices during their postsecondary careers. We also aimed to understand how often students engaged in, and faculty had witnessed, academic dishonesty, whether or not witnessing incidents of academic dishonesty corresponded with gender, year of experience, highest level of educational attainment, discipline, or their personal perceptions towards the importance of academic honesty, and whether students had been adequately taught what constitutes academic dishonesty. We found that an overwhelming majority of students viewed academic honesty as important, and that most students reported not engaging in academic dishonesty themselves despite 45.8% reporting that they had witnessed others engage in academic dishonesty. We also found that students were more likely to witness cheating as their postsecondary experience increased, that witnessing varied across disciplines and educational attainment, and that witnessing varied with student perceptions. However, we found no such patterns in faculty responses, but found that faculty are split on whether or not they believe incidents of academic honesty are increasing.
Lektüren des Ästhetischen – Ästhetische Lektüren. Alte und neue Hermeneutik
Authors: Gerok-Reiter Annette 
Published: December 2021

ZusammenfassungLektüren des Ästhetischen bilden einen ›Paradefall‹ hermeneutischen Verstehens. Zugleich jedoch kommt der hermeneutische Zugriff gerade hier an seine Grenze, werden Lektüren des Ästhetischen zu dessen ›Härtefall‹. Die grundsätzliche Skepsis gegenüber einem hermeneutischen Zugriff ebenso wie gegenüber Interpretationen, die vorrangig ästhetische Aspekte fokussieren, ist daher in den letzten Jahrzehnten durchaus in Relation zu sehen. Vor diesem Hintergrund möchte die Skizze pointieren, inwiefern die derzeitige ›Rückkehr der Ästhetik‹ mit einem Perspektivwechsel korreliert ist, der auch eine Neujustierung hermeneutischen Verstehens einfordert.
Verstandenhaben
Authors: Baßler Moritz 
Published: December 2021

ZusammenfassungDas ›Verstandenhaben‹, das, mit Gadamer gesprochen, zu den Grundeigenschaften des hermeneutischen Zirkels gehört, charakterisiert prominente gegenwärtige Tendenzen auch akademischer Literaturrezeption, denen eine wissenschaftliche Ausrichtung des Faches, so wird hier argumentiert, eher entgegenzuwirken hätte. Gerade das theoretisch-methodische Angebot der Hermeneutik bietet in dieser Auseinandersetzung keine zukunftsweisenden Perspektiven.
Proletarische Allegorese
Authors: Pornschlegel Clemens 
Published: December 2021

ZusammenfassungAusgehend von zwei Texten Simone Weils und Charles Baudelaires untersucht der Beitrag die religiöse Signatur der literarischen und politischen Moderne des 19. und 20. Jahrhunderts. Manifest wird sie in einem genuin allegorischen Sprach- und Weltverständnis, das sich gegen die schlechte Unendlichkeit einer techno-wissenschaftlich verdinglichten Welt richtet, die sich jeder Alteritätserfahrung verschließt. Religiöse Begriffe und Figuren sind in der literarischen Moderne nicht je schon uneigentliche Rede, sondern verlangen nach einer vorurteilsfreien Lektüre, die theologische Fragen nicht aus-, sondern miteinschließt. Dafür steht nicht zuletzt auch Walter Benjamins Lektüre Baudelaires ein.
Weathering events recorded in uppermost Hauterivian–lower Barremian clay-dominated continental successions from the NW Iberian Range: climatic vs. tectonic controls
Authors: Laita Elisa , Bauluz Blanca , Aurell Marcos , Bádenas Beatriz , Yuste Alfonso 
Published: December 2021

AbstractThe facies and clay mineral study of clay/marl-rich levels from the Torrelapaja Formation (latest Hauterivian–early Barremian, NW Iberian Range, NE Spain) allowed to establish the palaeoclimatic and palaeoenvironmental conditions under they were generated. The muddy levels and pisoids contained therein of two logs were sampled and studied by X-ray diffraction and optical and electron microscopy. A similar mineralogical upwards trend is recorded in both logs, with a decrease in calcite coupled with an increase in quartz and orthoclase content and constant proportions in goethite, hematite, diaspore, anatase, rutile, ilmenite, and clay mineral content. The lower muddy levels have higher kaolinite content than the upper levels, where illitic phases are the dominant clay minerals. Smectite and intergrowths of illitic phases and kaolinite are also detected upwards. The kaolinite and smectite textures indicate an authigenic origin, whereas the illitic phases are former phases acting as a substrate for kaolinite crystallization. Pisoids mineralogy and texture show an in-situ origin, but some are fractured, indicating reworking processes. The mineral association found in the muddy levels is characteristic of oxisols formed under warm and humid conditions. The upward decrease in kaolinite content is coeval with an increase in the illitic phases and quartz content, related to siliciclastic input, but is also coeval with the presence of authigenic smectite. This indicates a decrease in chemical weathering, not fully registered due to the siliciclastic contribution, which was possibly associated with a change to colder, drier conditions during the latest Hauterivian–early Barremian in the studied area.