bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic polypous rhinosinusitis and lung function in the profile of multi-organ pathology in children with cystic fibrosis in the Russian Federation
Authors: Polyakov D. P. , Daykhes N. A. , Yunusov A. S. , Karneeva O. V. , Petrov A. S. , Sherman V. D. , Chernyak A. V. , Gorinova Yu. V. 
Published: April 2021

Chronic rhinosinusitis (CRS), including chronic rhinosinusitis with nasal polyps (CRSwNP), is one of the manifestations of cystic fibrosis (CF). The paranasal sinuses (PNS) are considered as a reservoir of pathogenic microflora and a source of descending infection of the entire respiratory tract. Nevertheless, paranasal sinuses pathology is usually assessed in isolation from both the lower respiratory tract and the entire spectrum of multiple organ damage in CF.Aim. To determine the prevalence of CRSwNP and its correlation with other characteristics of CF in children in Russia.Methods. The study included data of 2216 children from 0 to 18 years old from 81 regions of the Russian Federation from the Registry of patients with cystic fibrosis in the Russian Federation for 2018. Children with an established diagnosis of CRSwNP (n = 599) were compared to those without this condition (n = 1 617). The prevalence was assessed in the subgroups by age, sex, respiratory function, nutritional status, microbiological status, complications, the need for various therapies, and the average duration of inpatient treatment during the year. The statistical analysis included parametric and nonparametric tests.Results. According to the Registry, the average prevalence of CRSwNP among children with CF was 27.03% and tended to increase with age. Children with CRSwNP had statistically significant higher incidence of homozygous F508del mutation, more common intermittent and chronic infection with P. aeruginosa, S. aureus (MSSA and MRSA), cystic fibrosis-associated diabetes mellitus with daily use of insulin, liver damage (as with or without cirrhosis), osteoporosis, a more frequent need for systemic antibacterial and inhalation (except for bronchodilators) therapy, as well as a relatively high need for hospital stay. Unexpectedly, the respiratory function indicators (FEV1, %, FVC, %) and body mass index turned out to be higher in the group of patients with nasal polyposis. A likely explanation is that the study included only children, and the lung function was not analyzed in the children and adolescents.Conclusion. The results suggest that CRSwNP is a predictor of adverse course of CF and requires attention from CF specialists and otorhinolaryngologists, as well as interdisciplinary collaborations.
Cost of therapy for cystic fibrosis in different age groups with consideration to the respiratory tract infection and complications
Authors: Furman E. G. , Shadrina V. V. , Maksimycheva T. Yu. , Sherman V. D. , Kondratyeva E. I. 
Published: April 2021

Despite the low prevalence of cystic fibrosis (CF), the costs of treating this disease are significant for the healthcare system. The aim of this economic study was to assess the total cost of drugs per year for children with CF, depending on age and course of the disease.Methods. For this pharmacoeconomic analysis, groups of “hypothetical” patients were formed according to the characteristics of the course of CF, taking into account the required volume of basic CF therapy, antibiotic therapy, and complications.Results. The cost of basic treatment for CF patients of different ages and disease progression in the hypothetical patient models can vary greatly. The cost of CF therapy increases significantly with age and Pseudomonas aeruginosa respiratory infection, especially in the patients with chronic infection, concomitant polyposis sinusitis, and low nutritional status.Conclusion. Patients with CF require regular follow-up with control of the microflora of the respiratory tract and effective eradication therapy for P. aeruginosa and other pathogenic microorganisms. Reducing infection rates and the severity of the disease can lead to significant cost savings.
Qtc Prolongation as Prognostic Marker in Organophosphate Poisoning
Authors: Thakur Dr. Digbijay Kumar , Gaire Dr. Dhruba , Jha Dr. Siddi Datri , Mahaseth Dr. Rameshwar 
Published: April 2021

Background
The long QT syndrome (LQTS) is a disorder of myocardial repolarization characterized by a prolonged QT interval on the electrocardiogram (ECG). This syndrome is associated with an increased risk of polymorphic ventricular tachycardia, a characteristic life-threatening cardiac arrhythmia also known as torsades de pointes. A rate related corrected QT interval (QTc) can be calculated as QT/√RR and normally is ≤0.44s. Some references given QTc upper normal limits as 0.43s in men and 0.45s in female. OP compound supposed to block K+ channel and Na+/Ca++ channel and hence causing prolongation of QT interval. As we know that prolongation of QT interval may precipitate polymorphic ventricular tachycardia and sudden cardiac death, so it become important in case of OP poisoning and related mortality. In this study, I calculated corrected QT interval in diagnosed cases of OP poisoning admitted at Bir Hospital and compared QTc among those with complications and without complication. I also tried to evaluate QTc as a predictor for duration of hospital stays, ICU admission, vasopressor and mechanical ventilation requirement, higher POP score and low GCS.
Lexical-Semantic Analysis of the Adjective Poor in English: Definitions, Synonyms, and Antonyms
Authors: Mendesheva M. M. 
Published: April 2021

The article introduces the lexical-semantic aspect of the adjective poor in English, its synonyms, and antonyms. The analysis featured five English dictionaries: Cambridge Advanced Learner's Dictionary & Thesaurus, Cobuild Advanced English Dictionary, The Free Dictionary, Longman Dictionary of Contemporary English, and Merriam-Webster Dictionary. The author analyzed the lexical-semantic variants of the adjective and determined its meanings. The component analysis allocated 46 semes and sememes, which were combined into eight thematic groups: 1. People: (poor) people / a group, poverty, emaciated, not very skilful (in a particular activity), needy, humble, meek; 2. Animal: (hungry) animal; 3. Material means: having, material, possessions, mean, petty / (little) money / insufficient wealth, used of land, barren (land), unproductive (land); 4. Lack / shortage: lacking / deficient; 5. Something material: very little of the substance, (little of a particular) substance, (poor) food; 6. Resources: supply (of something specified – resources, materials), (poor) country; 7. Evaluation: bad / not good, (being of a very low) quality, (being of a very low) quantity, (being of a very low) standard, inferior / very little (in quality), inferior (in value), (less) amount, (less) rate, (less) number, little / few, (in bad) condition, not normal, less (than adequate) / scanty / inadequate, negative, small (in worth), quality; 8. Emotional attitude: exciting , pity, (deserving) sympathy, unlucky, disappointing , disagreeable, indifferent, unfavorable, no pleasure. The adjective poor appeared to have 37 synonyms and 13 antonyms.
Guided Internet-Based Cognitive Behavioral Therapy for Depression: Implementation Cost-Effectiveness Study
Authors: Piera-Jiménez Jordi , Etzelmueller Anne , Kolovos Spyros , Folkvord Frans , Lupiáñez-Villanueva Francisco 
Published: April 2021

Background
Major depressive disorder is a chronic condition; its prevalence is expected to grow with the aging trend of high-income countries. Internet-based cognitive-behavioral therapy has proven efficacy in treating major depressive disorder.

Objective
The objective of this study was to assess the cost-effectiveness of implementing a community internet-based cognitive behavioral therapy intervention (Super@, the Spanish program for the MasterMind project) for treating major depressive disorder.

Methods
The cost-effectiveness of the Super@ program was assessed with the Monitoring and Assessment Framework for the European Innovation Partnership on Active and Healthy Ageing tool, using a 3-state Markov model. Data from the cost and effectiveness of the intervention were prospectively collected from the implementation of the program by a health care provider in Badalona, Spain; the corresponding data for usual care were gathered from the literature. The health states, transition probabilities, and utilities were computed using Patient Health Questionnaire–9 scores.

Results
The analysis was performed using data from 229 participants using the Super@ program. Results showed that the intervention was more costly than usual care; the discounted (3%) and nondiscounted incremental cost-effectiveness ratios were €29,367 and €26,484 per quality-adjusted life-year, respectively (approximately US $35,299 and $31,833, respectively). The intervention was cost-effective based on the €30,000 willingness-to-pay threshold typically applied in Spain (equivalent to approximately $36,060). According to the deterministic sensitivity analyses, the potential reduction of costs associated with intervention scale-up would reduce the incremental cost-effectiveness ratio of the intervention, although it remained more costly than usual care. A discount in the incremental effects up to 5% exceeded the willingness-to-pay threshold of €30,000.

Conclusions
The Super@ program, an internet-based cognitive behavioral therapy intervention for treating major depressive disorder, cost more than treatment as usual. Nevertheless, its implementation in Spain would be cost-effective from health care and societal perspectives, given the willingness-to-pay threshold of €30,000 compared with treatment as usual.
Membangun Desa Binaan Tanggap COVID-19, Lupus, Reumatik, dan Alergi: Upaya Menurunkan Angka Kejadian dan Mencegah Kekambuhan di Malang
Authors: Handono Kusworini , Wahono Cesarius Singgih , Barlianto Wisnu , Dewi Elvira Sari , Sari Tita Luthfia , Hasanah Dian , Rahman Perdana Aditya , Anshory Muhammad , Wulandari Desy , Sari Dewi Purnama , Endharti Agustina Tri , Nurdiana Nurdiana , Kalsum Umi , Susianti Hani , Kalim Handono 
Published: April 2021

Kurangnya pengetahuan masyarakat tentang COVID-19, lupus, reumatik, dan alergi mempengaruhi keberhasilan terapi, penurunan angka kejadian, dan pencegahan kekambuhan. Tujuan pengabdian masyarakat adalah membangun desa-desa binaan tanggap COVID-19, lupus, reumatik, dan alergi di Malang oleh Tim Kelompok Kajian Lupus, Autoimun, Reumatik, dan Alergi (LAURA) Universitas Brawijaya. Warga desa binaan diberikan penyuluhan berupa seminar awam dan pelatihan tentang pertolongan awal pada penyakit COVID-19, lupus, reumatik, dan alergi, kemudian diminta mengisi kuesioner posttest untuk mengukur pemahaman. Desa-desa binaan diberikan thermo-gun dan wastafel untuk menerapkan protokol kesehatan. Satu bulan kemudian dievaluasi adanya kejadian COVID-19, lupus, reumatik, dan alergi di desa binaan. Hasil evaluasi menunjukkan rata-rata warga desa binaan memahami 78,3% materi yang diberikan dan menerapkan protokol kesehatan sesuai yang diajarkan saat penyuluhan. Dilaporkan tidak ada kejadian COVID-19 serta kekambuhan lupus, reumatik, dan alergi dalam satu bulan terakhir kegiatan. Kesimpulan: pembangunan desa-desa binaan di Malang meningkatkan tanggap warga terhadap COVID-19, lupus, reumatik, dan alergi.
Approaching electrical circuit understanding with circuit builder virtual laboratory
Authors: Santoso Purwoko Haryadi , Munawanto Nino 
Published: April 2021

Nowadays, most students are familiar with the notebook for daily use. The compactness and flexibility of the notebook offer more benefits than a PC. The teachers can engage it during teaching physics. Hence, this research had developed an electrical circuit virtual experiment that acts like real experiments. It can be accessed easily by students in their notebook. This study introduces a flash-based animation Circuit Builder as a simulation designed to help students understand the electrical circuit. This study's purposes were: (1) to analyze the feasibility level of Circuit Builder for enhancing students’ electrical circuit mastery and (2) to know the effectiveness of Circuit Builder based on students’ electrical circuit mastery. Circuit Builder was developed by 4D (Define, Design, Develop, and Disseminate) model. The feasibility level was analyzed by CVI (Content Validity Index). Then, the effectiveness was tested with effect size. This study proved that the virtual laboratory "Circuit Builder” was feasible in physics class with a moderate effect size. The virtual laboratory could improve students’ electrical circuit mastery than doing practices with traditional laboratories.
Tsunami understanding media: Android-physics mobile learning to improve problem solving-skills and natural disaster preparedness
Authors: Abdillah Annas Jati , Mundilarto Mundilarto , Sulaiman Syazana 
Published: April 2021

This research aimed to determine the effectiveness of the implementation of tsunami understanding media through Android-based physics mobile learning in improving students' problem-solving skills and natural disaster preparedness. This study employed quasi-experiment research with a non-equivalent control group design. This research subjects were fifty-six students of class XI IPA at SMA N 1 Kretek, Bantul, Yogyakarta. The sampling technique employed in this research was the simple random sampling technique to determine the experimental and control groups. The research data had been obtained through pretest and posttest in the form of essay tests. The data obtained were then analyzed using N-gain. The analysis results were used to determine the effectiveness of the media using the Hotelling's Trace test in MANOVA test analysis. Normally distributed and homogeneous data are required to perform the multivariate analysis. The results showed that the tsunami understanding media through Android-based physics mobile learning improved students' problem-solving skills and natural disaster preparedness compared to the learning using PowerPoint presentation. The research decisions were based on the significant value that was smaller than 0.05 (0.000<0.05), and the value of the Partial Eta Squared was 0.359 in the broad category.
Suatu Pendekatan Pembelajaran; Quantum Teaching
Authors: Yuberti Yuberti 
Published: April 2021

Bagi seorang mahasiswa Fakultas Tarbiyah dan Keguruan, sangatdisadari bahwa produknya kelak adalah akan menjadi seorang guru yangdiharapkan profesional. Pengertian Profesional disini merupakan suatuhasil, hasil diperoleh dari suatu proses. Jika proses perkuliahan,pemahaman tentang makna dari suatu istilah belum dimengerti denganbaik, bagaimana dengan produknya kelak? Oleh sebab itu, dalam tulisan ini akan dibahas istilah-istilah dalam pembelajaran, khususnya konsep pendekatan pembelajaran. Penulis berharap dari apa yang dipaparkan akan memberikan pemahaman terhadap pendekatan dalam pembelajaran, khususnya pendekatan quantum learning atau quantum teaching yang bersumber dari konsep kefisikaan. Quantum adalah sebuah temuan yang telah menyelamatkan manusiadari bencana ultraviolet. Quantum Training telah menyelamatkan manusia dari bencana “ultrasekolah” dan “ultra belajar” Quantum pertama kali ditemukan oleh Max Planck pada akhir abad ke-19. Ia menemukan sebuah rumus fisika yang sahih yang dapat menanggulangi bencana ultraviolet. Sejak saat itu istilah Quantum digunakan pada banyak aspek kehidupan yang antara lain digunakan pada bidang pendidikan dan pembelajaran.Diabad ke-20 ini orang : dipaksa” belajar diruang kelas yang disusunsecara kaku dan terdiri dari meja dan kursi. Nilai dan ijasah/sertifikatmenjadi ukuran keberhasilan yang pada akhirnya pembelajaran merasabahwa belajar dan sekolah merupakan beban, seiring denganperkembangan dunia pendidikan, ditemukan sebuah pendekatanpengajaran yang disebut Quantum Teaching.
PEDAGOGI DAN TEKNOLOGI DALAM E-LEARNING Studi Kasus: Pengembangan E-Learning di Fakultas Tarbiyah dan Keguruan IAIN Raden Intan Lampung
Authors: Gunawan Indra 
Published: April 2021

Aspek pedagogi sangat berpengaruh terhadap pengembangan materi (content development) dan pembelajaran (learning) dengan memperhatikan teknik dan behavior interaksi antara dosen (lecturer) dan mahasiswa (students). Di sisi lain aspek teknologi berpengaruh terhadap pengembangan materi yang dinamis dan rich multimedia, serta menyediakan fiturfitur (features) komponen sistem e-learning. Mengintegrasikan kedua aspek tersebut dapat meningkatkan kualitas pengembangan materi yang didukung oleh system e-learning agar proses belajar-mengajar menjadi optimal. Subjective Analysis atas pengintegrasian kedua aspek tersebut dalam sistem e-learning yang digunakan-SCELE, menunjukkan bahwa lingkungan pembelajaran online dapat menghadirkan suasana sebagaimana pembelajaran konvensional.
INTEGRASI PENDIDIKAN KARAKTER DALAM PEMBELAJARAN DI SEKOLAH
Authors: Latifah Sri 
Published: April 2021

Salah satu pengertian pendidikan adalah proses memanusiakan manusia. Untuk meraih derajat manusia seutuhnya sangatlah tidak mungkin tanpa melalui proses pendidikan. Pendidikan harus dapat menghasilkan insan-insan yang memiliki karakter mulia, di samping memiliki kemampuan akademik dan keterampilan yang memadai. Salah satu cara untuk mewujudkan manusia yang berkarakter adalah dengan mengintegrasikan pendidikan karakter dalam setiap pembelajaran. Nilai-nilai karakter utama yang harus terwujud dalam sikap dan perilaku peserta didik sebagai hasil dari proses pendidikan karakter adalah jujur (olah hati), cerdas (olah pikir), tangguh (olah raga), dan peduli (olah rasa dan karsa). Pengintegrasian pendidikan karakter dalam pembelajaran dapat dilakukan dengan pemuatan nilai-nilai karakter dalam semua mata pelajaran yang diajarkan di sekolah dan dalam pelaksanaan kegiatan pembelajaran. Untuk itu guru harus mempersiapkan pendidikan karakter mulai dari perencanaan, pelaksanaan, hingga evaluasinya. Pelaksanaan pendidikan karakter di sekolah perlu didukung oleh keteladanan guru dan orang tua murid serta budaya yang berkarakter.
MODEL PEMBELAJARAN JUST IN TIME TEACHING (JITT) BERBANTUAN WEBSITE PADA TOPIK LISTRIK ARUS BOLAK-BALIK UNTUK MENINGKATKAN KETERAMPILAN BERPIKIR KREATIF SISWA SMA
Authors: Irwandani Irwandani 
Published: April 2021

Telah dilakukan penelitian dengan metode quasy experiment tentang penerapan pembelajaran JiTT berbantuan website untuk mengetahui peningkatan keterampilan berpikir kreatif siswa pada materi listrik arus bolak-balik. Sampel penelitian adalah siswa kelas X SMA tahun pelajaran 2012/2013. Sampel penelitian terbagi dalam dua kelas, yaitu kelas eksperimen dan kelas kontrol. Kelas eksperimen mendapatkan model pembelajaran JiTT berbantuan websitesedangkan kelas kontrol mendapat model pembelajaran JiTT tanpa bantuan website.Hasil uji statistik menunjukkan bahwakelas eksperimen secara signifikan lebih dapat meningkatkan keterampilan berpikir kreatif siswanyadibandingkan kelas kontrol. Dapat disimpulkan bahwa pembelajaran JiTT berbantuan website dapat lebih meningkatkan keterampilan berpikir kreatif siswa.
Modern Islam, Politics, and the Making of Religious Commodification Among Female Members of Majelis Taklim Circle in Bandar Lampung, Indonesia
Authors: Mulyadi Mulyadi , Jauhari Tontowi , Hidayat Mansur , Sugiono Arif 
Published: April 2021

Despite the common belief in society about the declining fate of religion in time of modernity, everyday behaviors of religious societies have shown that religion has been increasingly commodified for political purposes. This article aims to study the ways in which modernity has enabled the dynamic use of religious commodification in political sectors. Its main question is how political leaders have used religious doctrines, values, and symbols for gaining their electoral supports. Data of this research is collected through surveys among female Muslim members of Islamic learning circles (majelis taklim) in Bandar Lampung, the biggest city in the province of Lampung, where religious learning circles have increasingly flourished in the last few years. This research finds out ample evidence showing the significant influences of modernization and commodification of religion in determining political behaviors of the female members of Islamic learning circles. Modernization in the context of this research is defined as knowledge, urbanization, increased income, technological progress, social norms, social interaction, social institutions, and commodification of religion is identified as the acts of making religious teachings and activities as a commodity, empirically manifested in the form of transforming social relations into economic relations (relation oriented for economic interests, materialization of a thing spiritual).
QUALIDADE DA EDUCAÇÃO SUPERIOR E DESIGUALDADES: UM PANORAMA DOS TEMAS DE ESTUDO (2007 – 2017)
Authors: Silveira Diogo de Ávila Fontoura Julian , Corsetti Berenice 
Published: April 2021

A investigação aqui apresentada busca compreender a forma como as temáticas da qualidade da educação e desigualdades, são percebidas frente as pesquisas acadêmicas de Programas brasileiros de Pós-Graduação stricto sensu entre os anos de 2007 e 2017, a partir da identificação dos temas de pesquisa privilegiados por essas comunidades de pesquisa. Na produção dos dados, utilizamos os princípios de Estado de Conhecimento, a partir da pesquisa bibliográfica e seu foco histórico-bibliográfico, exploratório-investigativo, inventariante e descritivo. Os resultados desta investigação acabam por evidenciar a complexidade presente na articulação dos temas qualidade e desigualdades, além da presença marcada de distintos campos disciplinares para o entendimento dos fenômenos relacionados. A partir das categorias emergentes associadas aos contextos das políticas públicas, aos contextos sociais e aos contextos institucionais, temos um conjunto de temas de pesquisas desenvolvidos no período, em destaque aqueles relacionados a avaliação e garantia da qualidade; e a gestão institucional dos espaços acadêmicos a luz dos contextos institucionais.
“Greenness” in Chemistry Education – Look into Textbook Reaction Examples
Authors: Yang Huilin (Galen) 
Published: April 2021

Chemistry has played a dual role in the unfolding picture of global development.1 The chemical sciences have significantly improved overall quality of life but have also caused several severe environmental problems. To alter the public perception of chemistry from a “troublemaker” to a positive field necessary for global advancement, the United Nations sustainable development goals (SDGs) must be used to reposition chemistry in a broader context.2 The SDGs are just beginning to be incorporated into post-secondary chemistry education, creating the essential foundation for teaching students about the role of chemistry as the central sustainability science.3

We are investigating how sustainability has been incorporated into chemistry education. The work was carried out by analyzing the organic reactions used as examples in a widely adopted organic chemistry textbook (Organic Chemistry, 2nd edition, Oxford Press). These reactions were examined using a sustainability framework consisting of several existing mass- and energy- based “green chemistry” metrics. The idea of “green chemistry” was formulated in the 1990s to address the environmental crises caused by expanding urbanization, and provides a direction chemistry must take to ensure its development is sustainable. The results of our textbook analysis create a quantitative indicator of the overall “greenness” of the content used as the basis for chemistry courses in Canada.

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