bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement properties of patient-reported outcome measures (PROMs) in patients with hyperhidrosis: protocol for a systematic review
Authors: Gabes Michaela , Knüttel Helge , Apfelbacher Christian J. 
Published: June 2021

Abstract
Background
Hyperhidrosis is a chronic skin condition that impairs the patient’s quality of life (QoL). There are several patient-reported outcome measures (PROMs) for patients affected by hyperhidrosis available; however an evidence-based assessment of their quality has not been undertaken so far.

Objective
In our systematic review, we aim to identify all existing PROMs that were developed and/or validated for measuring patient-reported outcomes in patients with hyperhidrosis and assess their measurement properties in a transparent and structured way to give a recommendation for future clinical research.

Methods/design
Our systematic review aims to contain all PROMs developed and/or validated for patients with hyperhidrosis. We will perform a highly sensitive, systematic literature search including the databases MEDLINE (Ovid), EMBASE (Ovid), and Science Citation Index Expanded and Social Sciences Citation Index (Web of Science). Especially studies which evaluate, describe, or compare measurement properties of PROMs for patients with hyperhidrosis will be considered as eligible. Two independent reviewers will judge the eligibility of the studies found in the literature search. The study and PROM characteristics will be summarized in evidence tables. The methodological quality of each study will be assessed using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) Risk of Bias checklist. We will apply predefined and consensus-based quality criteria for good measurement properties. Subsequently, the quality of the evidence will be graded. Furthermore, aspects on interpretability and feasibility will be described. A final recommendation will be given.

Discussion
In our systematic review, we aim to provide a comprehensive description of the quality of all existing PROMs for patients with hyperhidrosis. The assessment of measurement properties, interpretability, and feasibility will serve as a guidance regarding the selection of PROMs for future clinical hyperhidrosis trials.

Systematic review registration
PROSPERO CRD42020170247
Intent-driven cloud resource design framework to meet cloud performance requirements and its application to a cloud-sensor system
Authors: Wu Chao , Horiuchi Shingo , Murase Kenji , Kikushima Hiroaki , Tayama Kenichi 
Published: June 2021

AbstractIn cloud service delivery, the cloud user is concerned about “what” function and performance the cloud service could provide, while the cloud provider is concerned about “how” to design proper underlying cloud resources to meet the cloud user’s requirements. We take the cloud user’s requirement as intent and aim to translate the intent autonomously into cloud resource decisions. In recent years, intent-driven management has been a widely spread management concept which aims to close the gap between the operator’s high-level requirements and the underlying infrastructure configuration complexity. Intent-driven management has drawn attention from telecommunication industries, standards organizations, the open source software community and academic research. There are various application of intent-driven management which are being studied and implemented, including intent-driven Software Defined Network (SDN), intent-driven wireless network configuration, etc. However, application of intent-driven management into the cloud domain, especially the translation of cloud performance-related intent into the amount of cloud resource, has not been addressed by existing studies. In this work, we have proposed an Intent-based Cloud Service Management (ICSM) framework, and focused on realizing the RDF (Resource Design Function) to translate cloud performance-related intent into concrete cloud computation resource amount settings that are able to meet the intended performance requirement. Furthermore, we have also proposed an intent breach prevention mechanism, P-mode, which is essential for commercial cloud service delivery. We have validated the proposals in a sensor-cloud system, designed to meet the user’s intent to process a large quantity of images collected by the sensors in a restricted time interval. The validation results show that the framework achieved 88.93 ~ 90.63% precision for performance inference, and exceeds the conventional resource approach in the aspects of human cost, time cost and design results. Furthermore, the intent breach prevention mechanism P-mode significantly reduced the breach risk, at the same time keeping a high level of precision.
Exploring a core psychopathology in disordered eating: the feelings of fat scale
Authors: Zhang Yichelle Y. , Burns Bruce D. , Touyz Stephen 
Published: June 2021

AbstractBackgroundFeelings of fat are common for people with eating disorders, but ways of measuring its intensity are needed. Therefore, our goal was to develop a self-report feelings of fat scale that asked participants to indicate how intensely they currently felt statements such as “I feel fat”. With such a scale we can determine how strongly feelings of fat relate to evidence of disordered eating.MethodsWe conducted three studies of eating disorders with undergraduate women taking introductory psychology classes. The combined sample was 472 participants. A previous eating disorder diagnosis was self-reported by 33 participants and a current diagnosis by 11. All participants completed the EDE-Q and the seven (Study 1) or nine item (Studies 2 and 3) “State Feelings of Fat” (SFF) scales we developed. Each item asked them to rate the intensity with which they felt statements such “I feel fat” on a seven-point scale from “not at all” to “the most I have ever felt”.ResultsBoth the seven and nine item SFF scales were highly coherent (Cronbach’s α were .94, .95 and .94), but factor analysis supported the seven-item version. We found high correlations between SFF and EDE-Q scores (Study 1: .816; Study 2: .808; Study 3: .841). SFF scores distinguished participants self-reporting no eating disorder diagnosis from those with a former diagnosis,t(361) = 2.33,p = .021, who in turn were distinguished from those with a current diagnosis,t(42) = 2.09,p = .043. Due to the high coherence of the scale, the single item “I feel fat” captured most of the variance in EDE-Q scores (r[472] = .793).ConclusionsWe have constructed an eating disorders relevant feelings of fat scale. Given that the EDE-Q is considered a valid questionnaire for measuring severity of eating disorders, our findings suggests that feelings of fat are core to the psychopathology of eating disorders. To the extent that EDE-Q scores are stable it also suggests that feelings of fat are surprisingly stable. Furthermore, the single item “I feel fat” alone may capture most of what the EDE-Q measures.
Micro-CT imaging of Thiel-embalmed and iodine-stained human temporal bone for 3D modeling
Authors: Halm Sebastian , Haberthür David , Eppler Elisabeth , Djonov Valentin , Arnold Andreas 
Published: June 2021

Introduction This pilot study explores whether a human Thiel-embalmed temporal bone is suitable for generating an accurate and complete data set with micro-computed tomography (micro-CT) and whether solid iodine-staining improves visualization and facilitates segmentation of middle ear structures. Methods A temporal bone was used to verify the accuracy of the imaging by first digitally measuring the stapes on the tomography images and then physically under the microscope after removal from the temporal bone. All measurements were compared with literature values. The contralateral temporal bone was used to evaluate segmentation and three-dimensional (3D) modeling after iodine staining and micro-CT scanning. Results The digital and physical stapes measurements differed by 0.01–0.17 mm or 1–19%, respectively, but correlated well with the literature values. Soft tissue structures were visible in the unstained scan. However, iodine staining increased the contrast-to-noise ratio by a factor of 3.7 on average. The 3D model depicts all ossicles and soft tissue structures in detail, including the chorda tympani, which was not visible in the unstained scan. Conclusions Micro-CT imaging of a Thiel-embalmed temporal bone accurately represented the entire anatomy. Iodine staining considerably increased the contrast of soft tissues, simplified segmentation and enabled detailed 3D modeling of the middle ear.
Structural stability and microscale behaviors of the fortress wall from the sixth century Baekje Kingdom in ancient Korea
Authors: Park Jun Hyoung , Park Seok Tae , Lee Chan Hee 
Published: June 2021

Abstract
The Gongsanseong Fortress in Gongju, Republic of Korea, is one of the most essential remains for historical research of Baekje Kingdom, and reinforces on the fortress wall has continuously been implemented since the sixth century to present. Through visual inspections of the fortress ramparts, sections in which structural deformations have occurred, and then they were classified by morphological characteristics based on lithofacies that compose the ramparts, shape of each rock, and construction method. Also, automatic sensors that can measure behavior changes of the ramparts, and the surrounding environment were installed to monitor microscale movements of the ramparts and changes in the surrounding microclimate. As a result, damages were shown intensively on the ramparts that retain specific morphological characteristics, and it has been discovered that, even for the ramparts located in an identical environment, morphological characteristics affect damages and structural deformations of the ramparts because of behavior changes for minutes. Such changes in behavior can be classified based on reversibility and predictability, and different management schemes must be applied based on behavior change patterns. If we continuously operate and develop this monitoring system, it is expected to be meaningfully utilized in efficient maintenance of the cultural heritage of the ramparts.
Radiopharmacokinetic modelling and radiation dose assessment of 223Ra used for treatment of metastatic castration-resistant prostate cancer
Authors: Höllriegl Vera , Petoussi-Henss Nina , Hürkamp Kerstin , Ocampo Ramos Juan Camilo , Li Wei Bo 
Published: June 2021

Abstract

Purpose
Ra-223 dichloride (223Ra, Xofigo®) is used for treatment of patients suffering from castration-resistant metastatic prostate cancer. The objective of this work was to apply the most recent biokinetic model for radium and its progeny to show their radiopharmacokinetic behaviour. Organ absorbed doses after intravenous injection of 223Ra were estimated and compared to clinical data and data of an earlier modelling study.

Methods
The most recent systemic biokinetic model of 223Ra and its progeny, developed by the International Commission on Radiological Protection (ICRP), as well as the ICRP human alimentary tract model were applied for the radiopharmacokinetic modelling of Xofigo® biodistribution in patients after bolus administration. Independent kinetics were assumed for the progeny of 223Ra. The time activity curves for 223Ra were modelled and the time integrated activity coefficients,

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in the source regions for each progeny were determined. For estimating the organ absorbed doses, the Specific Absorbed Fractions (SAF) and dosimetric framework of ICRP were used together with the aforementioned

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values.

Results
The distribution of 223Ra after injection showed a rapid plasma clearance and a low urinary excretion. Main elimination was via faeces. Bone retention was found to be about 30% at 4 h post-injection. Similar tendencies were observed in clinical trials of other authors. The highest absorbed dose coefficients were found for bone endosteum, liver and red marrow, followed by kidneys and colon.

Conclusion
The biokinetic modelling of 223Ra and its progeny may help to predict their distributions in patients after administration of Xofigo®. The organ dose coefficients of this work showed some variation to the values reported from clinical studies and an earlier compartmental modelling study. The dose to the bone endosteum was found to be lower by a factor of ca. 3 than previously estimated.
Deep brain stimulation of the Cuneiform nucleus for levodopa-resistant freezing of gait in Parkinson’s disease: study protocol for a prospective, pilot trial
Authors: Chang Stephano J. , Cajigas Iahn , Guest James D. , Noga Brian R. , Widerström-Noga Eva , Haq Ihtsham , Fisher Letitia , Luca Corneliu C. , Jagid Jonathan R. 
Published: June 2021

Abstract
Background
Freezing of gait (FOG) is a particularly debilitating motor deficit seen in a subset of Parkinson’s disease (PD) patients that is poorly responsive to standard levodopa therapy or deep brain stimulation (DBS) of established PD targets such as the subthalamic nucleus and the globus pallidus interna. The proposal of a DBS target in the midbrain, known as the pedunculopontine nucleus (PPN) to address FOG, was based on its observed pathology in PD and its hypothesized involvement in locomotor control as a part of the mesencephalic locomotor region, a functionally defined area of the midbrain that elicits locomotion in both intact animals and decerebrate animal preparations with electrical stimulation. Initial reports of PPN DBS were met with much enthusiasm; however, subsequent studies produced mixed results, and recent meta-analysis results have been far less convincing than initially expected. A closer review of the extensive mesencephalic locomotor region (MLR) preclinical literature, including recent optogenetics studies, strongly suggests that the closely related cuneiform nucleus (CnF), just dorsal to the PPN, may be a superior target to promote gait initiation.

Methods
We will conduct a prospective, open-label, single-arm pilot study to assess safety and feasibility of CnF DBS in PD patients with levodopa-refractory FOG. Four patients will receive CnF DBS and have gait assessments with and without DBS during a 6-month follow-up.

Discussion
This paper presents the study design and rationale for a pilot study investigating a novel DBS target for gait dysfunction, including targeting considerations. This pilot study is intended to support future larger scale clinical trials investigating this target.

Trial registration
ClinicalTrials.gov identifier: NCT04218526 (registered January 6, 2020)
Searching for impossible subspace trails and improved impossible differential characteristics for SIMON-like block ciphers
Authors: Wang Xuzi , Wu Baofeng , Hou Lin , Lin Dongdai 
Published: June 2021

AbstractIn this paper, we greatly increase the number of impossible differentials for SIMON and SIMECK by eliminating the 1-bit constraint in input/output difference, which is the precondition to ameliorate the complexity of attacks. We propose an algorithm which can greatly reduce the searching complexity to find such trails efficiently since the search space exponentially expands to find impossible differentials with multiple active bits. There is another situation leading to the contradiction in impossible differentials except for miss-in-the-middle. We show how the contradiction happens and conclude the precondition of it defined as miss-from-the-middle. It makes our results more comprehensive by applying these two approach simultaneously. This paper gives for the first time impossible differential characteristics with multiple active bits for SIMON and SIMECK, leading to a great increase in the number. The results can be verified not only by covering the state-of-art, but also by the MILP model.
Bearing failure in a mobile bearing unicompartmental knee arthroplasty: an uncommon presentation of an implant-specific complication
Authors: Vajapey Sravya P. , Alvarez Paul M. , Chonko Douglas 
Published: June 2021

Abstract
Background
We present two cases of unicompartmental knee arthroplasty (UKA) bearing failure in this report—one case of bearing dislocation and one case of bearing fracture. The causes of failure in both cases are evaluated in depth and recommendations are provided regarding intraoperative technique to reduce risk of bearing failure in mobile bearing UKAs.

Case presentation
In the first case, intraoperative evidence of metallosis and chronic pain preceding the traumatic event may indicate that the patient had attenuation of her collateral ligaments that precipitated the instability event. In the second case, the relatively atraumatic nature of the bearing fracture-dislocation and intraoperative evidence of extensive poly wear suggest that the bearing fracture was likely due to a 3-mm bearing selection in the initial surgery.

Conclusions
This case report shows that late bearing in mobile bearing unicompartmental knee arthroplasty can often be a multifactorial event and treatment must address all the risk factors that led to bearing dislocation. Bearing fracture is a very rare complication associated with mobile bearing UKA and patients with thin polyethylene inserts are at risk for bearing fracture even in the absence of poly wear.
Can intraoperative ultrasound replace the frozen section in the assessment of ex vivo sentinel lymph node biopsy in early breast cancer in countries with limited resources?
Authors: Rahman Rasha Wessam Abdel , Khallaf Emad Salaheldin , Salaheldin Lamia Adel , Hafez Mohamed Nasr , Fayed Mohannad Aly , Soliman Somia Abdulatif Mahmoud 
Published: June 2021

AbstractBackgroundAccurate staging and proper management of axillary lymph nodes (ALNs) in breast cancer patients are important for treatment. Surgical management of the axilla has evolved greatly in the last 20 years. Sentinel lymph node biopsy (SLNB), which was first investigated in the early 1990s, has replaced routine axillary lymph node dissection. This study evaluates the capability of using an ultrasound (US) as an alternative tool for the frozen section in the assessment of the ex vivo sentinel lymph node biopsy in countries with limited resources.ResultsThe study is a prospective study that included 216 female patients with early breast cancer and negative axillary lymph nodes. All excised lymph nodes were examined by the intraoperative US and frozen section examinations. All the results were correlated with the final histopathological results. The number of negative nodes by US, frozen, and paraffin section examination was 58.30%, 69.40%, and 69.40%, respectively. The number of positive nodes by the US, frozen, and paraffin section examinations was 41.70%, 30.60%, and 30.60% respectively. The sensitivity, specificity, PPV, NPV, and accuracy of US in the detection of positive lymph nodes were 95.45%, 82%, 70%, 97.62%, and 86.11%, respectively, and the sensitivity, specificity, PPV, NPV, and accuracy of frozen examination in the detection of positive lymph nodes were 90.91%, 96%, 90.91%, 96%, and 94.44%, respectively.ConclusionIntraoperative US is a good negative test in the assessment of ex vivo SLNB, but it is not a good positive test, so it cannot replace the intraoperative frozen section in the assessment of SLNs.
Can diffusion and T2 star-weighted magnetic resonance imaging aid in the diagnosis of ectopic endometrium?
Authors: Raafat Mariam , Talaat Soha H. , Abdelghaffar Salma M. , Ali Engy A. 
Published: June 2021

Abstract
Background
Endometriosis is a common gynecologic disorder characterized by the implantation of the endometrial tissue ectopically outside the endometrial cavity. It affects about 10% of females at the childbearing period and is estimated to be present up to 20–50% in women complaining of infertility. While laparoscopy is considered the mainstay for diagnosis, magnetic resonance imaging (MRI) is recognized as a useful tool for definitive diagnosis, pre-surgical planning, and determining whether the patient will require multi-specialty involvement. The aim of this study is to evaluate the performance of MRI with the addition of diffusion-weighted imaging (DWI) and T2 star (T2*) to conventional MRI, for the accurate assessment of ectopic endometrium.

Results
Endometriotic lesions that showed diffusion restriction on DWI were 80.7%, and 96.1% of the endometriotic lesions had signal voids on the T2*W sequence, whereas only 65.4% of the lesions had typical signal intensities on T1WI and T2WI. Diagnostic performance of the MRI examination was improved by the use of the diffusion sequence and better improved by the T2* sequence, compared to the conventional MR protocol sensitivity (SE) = 96.12% and specificity (SP) = 85.7% in T2*-weighted images, SE = 80.7% and SP = 71.4% in DWI, and SE = 65.4% and SP = 71.4% in conventional MRI. P value for conventional MRI was 0.1, which is of no statistical significance (p < 0.05). P value for DWI was 0.016, which is statistically significant (p < 0.05). P value for T2*WI was 0.001, which is more statistically significant (p < 0.05) and could be adequately correlated with laparoscopy.

Conclusion
DWI and T2* significantly increase MRI diagnostic accuracy by allowing the detection of the hemorrhagic character of the endometriotic lesions. Studies with a large sample size are needed to confirm that they can replace invasive laparoscopy for the diagnosis of endometriosis.
Donor-derived CD7 CAR T cells for T-cell acute lymphoblastic leukemia.
Authors: Pan Jing , Pan Jing , Deng Biping , Ling Zhuojun , Song Weiliang , Xu Jinlong , Duan Jiajia , Wang Zelin , Chang Alex , Feng Xiaoming 
Published: June 2021

10001 Background: Despite the success of chimeric antigen receptor T cell therapy in B cell malignances, there is currently no proved CAR T treatment for T cell neoplasms. We provide first evidence support the use of donor derived CAR T cells in T cell leukemia. Methods: In this phase 1 trial, CD7 CAR T cells were manufactured with T cells from prior SCT prior to a single infusion at doses of 5 × 105 or 1 × 106 (± 30%) cells per kilogram of body weight. donors, or from new donors who were HLA-matched or haploidentical, via leukopheresis and transduced with a lentiviral vector which carries a CD7 CAR construct. The primary endpoint was safety. Short-term efficacy was also assessed. Results: Results of 20 enrolled patients who received infusion are reported. Of 20 patients, 12 received previous HSCT-donor derived CAR T cells and 8 received fresh haplo-identical donor derived CAR T cells and plan to received transplantation as consolidation after remission.Adverse events included grade 3-4 hematologic toxicity in all (100%), grade 3-4 and grade 1-2 cytokine release syndrome in 2 (10%) and in 18 (90%), grade 1 neurotoxicity in 3 (15%), grade 1-2 graft-versus-host disease in 12 (60%), and grade 1 viral activation in 3 (15%) patients. Nineteen (95%) patients had a response, including 18 (90%) with complete remission and 1 (5%) with partial remission. Of 19 responders, 7 were bridged to SCT and remained minimal residual disease (MRD)-negative until last visit; 12 were followed up at a medium of 4.4 months, among whom 9 remained MRD-negative, 1 had a relapse, 1 discontinued for other treatment, and 1 died of pulmonary fungal infection at 5.5 months. CAR cells mostly persisted beyond 3 months. Patient CD7-positive healthy T cells were depleted, while CD7-negative T cells increased. Conclusions: We report the initial toxicity profile and anti-leukemia activity of a donor-derived CD7-targeted cellular immunotherapy for patients with relapsed or refractory T-ALL. (Funded by the National Key R&D program; ChiCTR.org number, ChiCTR2000034762). Clinical trial information: ChiCTR2000034762. [Table: see text]