bluuebunny/crossref_metadata_2025_split huggingface dataset:
BUILDING URBAN CLIMATE CHANGE ADAPTATION STRATEGIES: THE CASE OF RUSSIAN ARCTIC CITIES
Authors: Bobylev Nikolai , Gadal Sebastien , Konyshev Valery , Lagutina Maria , Sergunin Alexander 
Published: July 2021

AbstractRussian Arctic is a highly urbanized region, with most towns built in the Soviet era to facilitate extraction industries as well as provide and maintain military facilities. Global environmental and developmental changes, as well as national political decisions open up Russia’s Arctic to massive investment, industrial and socioeconomic development. How do Russian Arctic cities, towns, and municipalities reflect on new opportunities in terms of designing their climate change adaptation strategies at a local level? Starting with theoretical discourse on urban climate change adaptation strategy, this research examines state-of-the-art, challenges and trends in planning for adaptation measures in Russia’s Arctic industrial centers. Special attention is given to a comparative analysis of the cities’ climate change adaptation strategies. The role of civil society institutions and business community in the adaptation strategy planning process is explored. Moreover, conflict sensitive approaches to ensure participatory processes for designing and implementing adaptation measures are discussed. The field component of research is based on cities of Apatity, Arkhangelsk, Murmansk, Norilsk, Salekhard, Severodvinsk and towns of Monchegorsk, Nickel and Vorkuta. The study concludes that in spite of significant challenges identified, the total “balance sheet” of the Arctic cities’ efforts to enhance their adaptive capacities is quite positive: Russian northern urban settlements do their best in addressing existing challenges via planning for sustainability approach. However, there is more to do and municipalities should learn from one another’s experiences, as the different approaches can be helpful in developing adequate climate change adaptation strategies at the local level.
Citizenship and Sentencing: Assessing Intersectionality in National Origin and Legal Migration Status on Federal Sentencing Outcomes
Authors: Koo Doyun , Feldmeyer Ben , Holmes Bryan 
Published: July 2021

Objectives: This study seeks to understand how national origin and legal migration status of noncitizen defendants in federal criminal courts shape incarceration and sentence length decisions. Method: The authors use annual United States Sentencing Commission (USSC) Monitoring of Federal Criminal Sentences (MFCS) datasets (2011–2016) to examine the impact of defendant’s (1) national origin and (2) legal versus illegal migration status on incarceration and sentence length decisions in federal criminal courts. In addition, in order to account for effects of immigration cases, supplemental analyses are conducted for (1) non-immigration offenses and (2) immigration-only offenses. Results: For the incarceration decision, noncitizen defendants have higher odds of incarceration than U.S. citizens, net of other factors. These effects are less consistent in the sentence length decision. These relationships systemically differ across national origin and legal migration status. Conclusions: Punishment disadvantages based on one’s citizenship are particularly pronounced for defendants from Mexico, Latin America, and Africa and especially for those with “illegal” migration status. As noncitizen populations continue to grow in federal courts and in the U.S. more broadly, understanding and addressing these citizenship disparities in punishment will be increasingly important.
Unusual cases of suicidal electrocution using a homemade device
Authors: Mesrati Med Amin , Mahjoub Yosra , Boussaïd Marwa , Limem Hiba , Abdejlil Nouha , Chadly Ali , Aissaoui Abir 
Published: July 2021

Background The common methods of suicide are hanging and poisoning. Suicidal electrocution using a homemade device is very rare. Victims usually possess knowledge of electrical circuits. Here, we report two cases of suicide by electrocution using a homemade device. Case presentation: Case 1: A retired electrical technician was found unresponsive in his bedroom, with two bare copper wires; one encircling the index finger of the left hand, and the other placed in the mouth. The other ends of the wires were connected to a wall plug supplying 220 V current. Forensic autopsy and microscopic findings attributed death to suicidal electrocution. Case 2: A 51-year-old-man was found dead in the bathroom with bare copper wires encircling both wrists and connected to a wall plug carrying 220 V current. Death scene investigation, necropsy, histological tests and toxicological screening indicated suicide by electrocution.
Facial Paresis and Pulsatile Middle Ear Mass
Authors: Lopez Betzamel , Naples James G. 
Published: July 2021

Significance Statement Head and neck paragangliomas are uncommon pathologies that present with common symptoms such as pulsatile tinnitus and aural pressure. This article highlights an unusual presentation of a patient with facial paresis who was found to have a jugular paraganglioma. Emphasis is placed on how the otologic examination showed a pulsatile middle ear mass that led to the diagnosis. This case illustrates the importance of maintaining a healthy degree of clinical suspicion when encountering common complaints.
The Safety and Efficacy of Desmopressin in Patients With Intracranial Hemorrhage and a History of Alcohol Use
Authors: Gunther Michelle , Witenko Corey J. , Prust Morgan , Salerno David , Berger Karen 
Published: July 2021

Background: Patients with a history of alcohol use disorder are at an increased risk of hematoma expansion following intracranial hemorrhage (ICH) due to the effects of alcohol on platelet aggregation. Desmopressin (DDAVP) improves platelet aggregation and may decrease hematoma expansion in patients with ICH. However, DDAVP may also increase the risk of hyponatremia and thrombotic events. Evidence is limited regarding the safety and efficacy of DDAVP in alcohol use (AU)-associated ICH. Methods: This was a retrospective chart review of adult patients with radiographic evidence of ICH and a confirmed or suspected history of alcohol use upon admission. Patients were categorized into groups based on DDAVP administration. Safety outcomes included hyponatremia (serum sodium <135 mEq/L or decrease in serum sodium of ≥ 5 mEq/L for patients with baseline sodium <135 mEq/L) within 24 hours of ICH and thrombotic events within 7 days of ICH. The primary efficacy outcome was the incidence of hematoma expansion, defined as any expansion of the hemorrhage noted on repeat imaging within 32 hours. Results: In total, 52 patients were included in the safety analysis (27 DDAVP and 25 non-DDAVP). Although hyponatremia was numerically higher in the DDAVP group, there was no significant difference between groups (19.2% vs 4.2%, P = 0.192). Thrombotic complications were similar between the DDAVP and non-DDAVP groups (11.1% vs. 8%, P = 1.0). Thirty-nine patients met criteria for hemostatic efficacy analysis. There was no difference in hematoma expansion between the DDAVP and non-DDAVP groups (23.1% vs 34.6%, P = 0.71) and these findings were consistent after adjusting for differences in baseline characteristics (OR 0.63, 95% CI 0.1-3.3). Conclusion: The administration of DDAVP was not associated with adverse safety events, but did not significantly reduce the incidence of hematoma expansion in patients with AU-associated ICH.
Ophthalmologic manifestations in patients with antiphospholipid antibodies: Beware of iatrogenic complications
Authors: Menet Justine , Agrinier Nelly , Dufrost Virginie , Conart Jean-Baptiste , Wahl Denis , Duprez Karine Angioi , Zuily Stéphane 
Published: July 2021

Background Antiphospholipid syndrome (APS) is characterized by several clinical manifestations such as venous and arterial thrombosis associated with persistent antiphospholipid antibodies (aPL). Several studies confirmed that retinal vein occlusion was the most common APS ocular manifestation. The purpose of this study was to identify ophthalmologic manifestations in a homogeneous cohort of well-defined persistently aPL-positive patients and to determine variables associated with these manifestations. Methods APL-positive patients were selected from two research programs. All ophthalmologic manifestations including those related to APS were recorded. Results A total of 117 patients were included and 10 of them had APS-related ophthalmologic manifestations (glaucoma, hydroxychloroquine-related maculopathy, anterior acute uveitis, anterior ischemic optic neuropathy). Systemic Lupus Erythematosus (SLE) (OR = 3.4[95%CI; 0.9-12.7), corticosteroids (OR = 9.0 [95%CI; 2.2-37.7]) and aPL-related nephropathy (OR = 7.1 [95%CI; 1.7-30.0]) were significatively associated with the risk of APS-related ophthalmologic manifestations. Conclusion Most of ocular manifestations in this study were iatrogenic related to corticosteroids or hydroxychloroquine. Patients with SLE, small vessel thrombosis in general, or with aPL-related nephropathy in particular, seemed at higher risk to develop APS-related ophthalmologic manifestations thus deserving adequate monitoring.
The relationship between the modified National Institute of Health activity and chronicity scoring system, and the long-term prognosis for lupus nephritis: A retrospective single-center study
Authors: Nakagawa Shiori , Toyama Tadashi , Iwata Yasunori , Oshima Megumi , Ogura Hisayuki , Sato Koichi , Yamamura Yuta , Miyakawa Taro , Kitajima Shinji , Hara Akinori , Sakai Norihiko , Shimizu Miho , Wada Takashi 
Published: July 2021

Background The revision of International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification guidelines for lupus nephritis (LN) was suggested by a working group, who recommended a modified National Institute of Health (NIH) activity and chronicity scoring system to evaluate active and chronic LN lesions. However, whether this approach was useful for estimating long-term prognosis for LN patients is unclear. Methods We conducted a retrospective cohort study in Japanese subjects with biopsy-proven LN, between 1977 and 2018. Pathologic lesions were evaluated based on ISN/RPS 2003 classifications and the modified NIH scoring system. Patients were grouped by activity index (low, 0–5; moderate, 6–11; high, 12–24), and chronicity index (low, 0–2; moderate, 3–5; high, 6–12). The primary outcome was a composite of end-stage kidney disease (ESKD) or all-cause death, and the secondary outcome was ESKD alone. Results Sixty-six subjects with a median age of 31 years were included. During median follow-up (11.5 years), 15 patients reached the primary outcome: 10 had ESKD, four had died, and one had ESKD and died. Kaplan–Meier analysis showed that the cumulative primary outcome incidence increased with a higher chronicity index (log-rank trend p < 0.001). From multivariable survival analysis, moderate (hazard ratio [HR] 6.17, 95% confidence interval [CI] 1.14 to 33.20; p = 0.034) and high chronicity indices (HR 20.20, 95% CI 1.13 to 359.82; p = 0.041) were risk factors for the primary outcome. Conclusion Moderate and high chronicity indices were associated with an increased ESKD risk for LN.
Methyl donor micronutrients, CD40-ligand methylation and disease activity in systemic lupus erythematosus: A cross-sectional association study
Authors: Vordenbäumen Stefan , Sokolowski Alexander , Rosenbaum Anna , Gebhard Claudia , Raithel Johanna , Düsing Christina , Chehab Gamal , Richter Jutta G , Brinks Ralph , Rehli Michael , Schneider Matthias 
Published: July 2021

Objective Hypomethylation of CD40-ligand (CD40L) in T-cells is associated with increased disease activity in systemic lupus erythematosus (SLE). We therefore investigated possible associations of dietary methyl donors and products with CD40L methylation status in SLE. Methods Food frequency questionnaires were employed to calculate methyl donor micronutrients in 61 female SLE patients (age 45.7 ± 12.0 years, disease duration 16.2 ± 8.4 years) and compared to methylation levels of previously identified key DNA methylation sites (CpG17 and CpG22) within CD40L promotor of T-cells using quantitative DNA methylation analysis on the EpiTYPER mass spectrometry platform. Disease activity was assessed by SLE Disease Activity Index (SLEDAI). Linear regression modelling was used. P values were adjusted according to Benjamini & Hochberg. Results Amongst the micronutrients assessed (g per day), methionine and cysteine were associated with methylation of CpG17 (β = 5.0 (95%CI: 0.6-9.4), p = 0.04; and β = 2.4 (0.6-4.1), p = 0.02, respectively). Methionine, choline, and cysteine were additionally associated with the mean methylation of the entire CD40L (β = 9.5 (1.0-18.0), p = 0.04; β = 1.6 (0.4-3.0), p = 0.04; and β = 4.3 (0.9-7.7), p = 0.02, respectively). Associations of the SLEDAI with hypomethylation were confirmed for CpG17 (β=-32.6 (-60.6 to -4.6), p = 0.04) and CpG22 (β=-38.3 (-61.2 to -15.4), p = 0.004), but not the mean methylation of CD40L. Dietary products with the highest impact on methylation included meat, ice cream, white bread, and cooked potatoes. Conclusions Dietary methyl donors may influence DNA methylation levels and thereby disease activity in SLE.
Effects of Vanadium Inhalation and Sweetened Beverage Ingestion in Mice: Morphological and Biochemical Changes in the Liver
Authors: Cervantes-Valencia María Eugenia , González-Villalva Adriana , Cano-Gutiérrez Gumaro , Albarrán-Alonso Juan Carlos , Fortoul Teresa Imelda 
Published: July 2021

The aim of this report was to evaluate the morphological and biochemical changes in the liver by the inhalation of vanadium and consumption of sweetened beverages in a subchronic murine model. Forty CD-1 male mice were randomly divided into four groups: control, vanadium (V), sucrose 30% (S), and vanadium–sucrose (V + S). V was inhaled (1.4 mg/m3) for 1h, twice/week; 30% sucrose solution was given orally ad libitum. Blood samples were obtained for AST, ALT, and LDH determination. Liver samples were processed for histological and oxidative stress immunohistochemical evaluation with 4-hydroxynonenal at weeks 4 and 8 of exposure. Regarding liver function tests, a statistically significant increase ( P < 0.05) was observed in groups V, S, and V + S at weeks 4 and 8 compared to the control group. A greater number of hepatocytes with meganuclei and binuclei were observed in V and V + S at week 8 compared to the other groups. Steatosis and regenerative changes were more extensive in the eighth week V + S group. 4-Hydroxynonenal immunoreactivity increased in the V + S group at both exposure times compared to the other groups; however, the increment was more evident in the V + S group at week 4 compared to the V + S group at week 8. An increase in De Ritis ratio (>1) was noticed in experimental groups at weeks 4 and 8. Findings demonstrate that in the liver, V, S, and V + S induced oxidative stress and regenerative changes that increased with the length of exposure. Results support possible potentiation of liver damage in areas with high air pollution and high-sweetened beverage consumption.
Four-Week Repeated Intravenous Dose Toxicity of Self-Assembled-Micelle Inhibitory RNA-Targeting Amphiregulin in Mice
Authors: Kim Hyeon-Young , Kim Tae Rim , Kim Sung-Hwan , Kim In-Hyeon , Lim Je-Oh , Park Jun Hong , Yun Sungil , Lee In-Chul , Park Han-Oh , Kim Jong-Choon 
Published: July 2021

The present study investigated the potential subchronic toxicity of self-assembled-micelle inhibitory RNA-targeting amphiregulin (SAMiRNA-AREG) in mice. The test reagent was administered once-daily by intravenous injection for 4 weeks at 0, 100, 200, or 300 mg/kg/day doses. Additional recovery groups (vehicle control and high dose groups) were observed for a 2-week recovery period. During the test period, mortality, clinical signs, body weight, food consumption, ophthalmology, urinalysis, hematology, serum biochemistry, gross pathology, organ weight, and histopathology were examined. An increase in the percentages of basophil and large unstained cells was observed in the 200 and 300 mg/kg/day groups of both sexes. In addition, the absolute and relative weights of the spleen were higher in males given 300 mg/kg/day relative to the concurrent controls. However, these findings were considered of no toxicological significance because the changes were minimal, were not accompanied by other relevant results (eg, correlating microscopic changes), and were not observed at the end of the 2-week recovery period indicating recovery of the findings. Based on the results, SAMiRNA-AREG did not cause treatment-related adverse effects at dose levels of up to 300 mg/kg/day in mice after 4-week repeated intravenous doses. Under these conditions, the no-observed-adverse-effect level of the SAMiRNA-AREG was ≥300 mg/kg/day in both sexes and no target organs were identified.
Costs comparison of treating diabetic macular edema with aflibercept, ranibizumab or dexamethasone at 1 year in France (INVICOST study)
Authors: Gascon Pierre , Borget Isabelle , Comet Alban , Carton Laurence , Matonti Frédéric , Dupont-Benjamin Laure 
Published: July 2021

Purpose: INVICOST, a medico-economic analysis, compared costs of managing treatment-naive patients with diabetic macular edema (DME) receiving intravitreal injections (IVIs) of aflibercept (AFL), dexamethasone implant (DXI) or ranibizumab (RAN) over 1 year. Methods: Healthcare resource use and associated costs were estimated using individual patient data from INVICTUS, a prospective, open-label, monocentric study. Healthcare costs comprised direct medical costs such as drug acquisition and administration, consultations and ophthalmological procedures. Costs were assessed from the French National Health Insurance perspective using published national tariffs expressed in 2019 euros. Results: Of the 60 treated eyes, 48 had no treatment switch; 14 received AFL, 19 received DXI and 15 received RAN. AFL-treated eyes received an average of 6.5 IVIs, DXI-treated patients received 2 IVIs and RAN-treated received 6.8 IVIs. All treated eyes received an initial prescription for adjunctive ocular medications and 349 follow-up procedures were performed including an average of 3.9 optical coherence tomography and 3.2 retinography procedures per eye. Average total direct cost of per-eye treatment was €4516 (€1128–€8257). Average cost was €5782 for eyes treated with AFL, €2779 with DXI and €5536 with RAN. Drug therapy was the cost driver: €4394 (76%) for AFL, €1915 for DXI (69%) and €4268 (77%) for RAN. Conclusion: The difference in total treatment cost is largely explained by the significantly lower frequency of IVI and annual cost of therapy with DXI, compared with AFL and RAN. INVICOST is the first study comparing treatment costs with AFL, DXI and RAN in France in current clinical practice.
Relations between phonological production, grammar and the lexicon in bilingual French-English children
Authors: Kehoe Margaret , Friend Margaret , Poulin-Dubois Diane 
Published: July 2021

Aims and objectives: This study examines multiple associations between language domains in bilingual children with a focus on phonology. Previous studies indicate within- but not cross-language associations between vocabulary and grammar in bilingual children. We investigate whether the relation between phonology and other language domains differs from the one reported between vocabulary and grammar. Methodology: Canadian French-English bilingual children ( n = 31), aged 31 months, participated in 2 free-play sessions, from which lexical, grammatical and phonological information was extracted. The children’s parents completed the MacArthur-Bates Communicative Developmental Inventories and its Canadian French adaptation providing additional information on vocabulary and grammar in each of the children’s languages. They also completed a questionnaire on their children’s exposure to French and English. Data analysis: Within and cross-language relations between phonology, vocabulary and grammar were investigated using correlational analyses and mixed logistic regression. Findings: Correlational analyses did not reveal significant cross-language relations between phonology, vocabulary and grammar. However, mixed logistic regression, which controlled for language exposure effects, indicated that phonology was influenced by vocabulary and grammar both within and across languages. Originality: This study is one of the first to study cross-domain relations involving phonology in young bilingual children. Implications: Overall, the findings suggest that phonology displays a pattern of relations that is different from other language domains engendering between-language effects due to a language-general component.
Outcome Metrics in the Treatment of Distal Radius Fractures in Patients Aged Above 50 Years: A Systematic Review
Authors: Fogel Nathaniel , Mertz Kevin , Shapiro Lauren M. , Roe Allison , Denduluri Sahitya , Kamal Robin N. 
Published: July 2021

Background The inclusion of patient-reported outcome measures (PROMs) serves to better quantify aspects of patient outcomes missed with objective measures, including radiographic indices and physical examination findings. We hypothesize that PROMs are inconsistently and heterogeneously captured in the treatment of distal radius fractures. Methods We performed a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines of all level I and II randomized controlled trials (RCTs) of distal radius fracture treatment of any modality for those older than 50 years of age from January 2008 to January 2018. A total of 23 studies were included in the final analysis. The metrics used by each study to assess outcomes were collected, compared, and described. Results Physical examination findings and radiographic measures were reported in 70% and 74% of studies, respectively. Patient-reported outcomes measures were used to assess outcomes in 74% of studies. Only the Disabilities of the Arm, Shoulder, and Hand was used in greater than half of the studies (57%). Pain scores were assessed in 39% of studies and complications in only 26%. Conclusions There is substantial heterogeneity and lack of standardization in the collection of both objective outcome measures and PROMs in level I and II RCTs for the treatment of distal radius fractures. The ability to compare between studies or aggregate data among studies is therefore limited. Radiographic and physical examination findings remain frequently reported despite known limitations of these metrics. The routine collection of PROMs after the treatment of distal radius fractures can ensure care is directed toward improving what is most important to patients.