bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Inflammatory lncRNAs Prognostic Signature for Predicting the Prognosis of Low-Grade Glioma Patients
Authors: Xiang Zijin , Chen Xueru , Lv Qiaoli , Peng Xiangdong 
Published: August 2021

BackgroundAs immunotherapy has received attention as new treatments for brain cancer, the role of inflammation in the process of glioma is of particular importance. Increasing studies have further shown that long non-coding RNAs (lncRNAs) are important factors that promote the development of glioma. However, the relationship between inflammation-related lncRNAs and the prognosis of glioma patients remains unclear. The purpose of this study is to construct and validate an inflammation-related lncRNA prognostic signature to predict the prognosis of low-grade glioma patients.MethodsBy downloading and analyzing the gene expression data and clinical information of the Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) patients with low-grade gliomas, we could screen for inflammatory gene-related lncRNAs. Furthermore, through Cox and the Least Absolute Shrinkage and Selection Operator regression analyses, we established a risk model and divided patients into high- and low-risk groups based on the median value of the risk score to analyze the prognosis. In addition, we analyzed the tumor mutation burden (TMB) between the two groups based on somatic mutation data, and explored the difference in copy number variations (CNVs) based on the GISTIC algorithm. Finally, we used the MCPCounter algorithm to study the relationship between the risk model and immune cell infiltration, and used gene set enrichment analysis (GSEA), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses to explore the enrichment pathways and biological processes of differentially expressed genes between the high- and low-risk groups.ResultsA novel prognostic signature was constructed including 11 inflammatory lncRNAs. This risk model could be an independent prognostic predictor. The patients in the high-risk group had a poor prognosis. There were significant differences in TMB and CNVs for patients in the high- and low-risk groups. In the high-risk group, the immune system was activated more significantly, and the expression of immune checkpoint-related genes was also higher. The GSEA, GO, and KEGG analyses showed that highly expressed genes in the high-risk group were enriched in immune-related processes, while lowly expressed genes were enriched in neuromodulation processes.ConclusionThe risk model of 11 inflammation-related lncRNAs can serve as a promising prognostic biomarker for low-grade gliomas patients.
The Associations Between White Matter Disruptions and Cognitive Decline at the Early Stage of Subcortical Vascular Cognitive Impairment: A Case–Control Study
Authors: Qiao Yanan , He Xuwen , Zhang Junying , Liang Ying , Shao Wen , Zhang Zhanjun , Zhang Sihang , Peng Dantao 
Published: August 2021

ObjectiveEmerging evidence suggests that white matter (WM) disruption is associated with the incidence of subcortical vascular cognitive impairment (SVCI). However, our knowledge regarding this relationship in the early stage of SVCI is limited. We aimed to investigate the associations between WM disruptions and cognitive declines at the early stage of SVCI.MethodWe performed a case–control study, involving 22 cases and 19 controls. The cases were patients at the early stage of SVCI, which was defined as subcortical ischemic vascular disease with normal global cognitive measures (pre-SVCI). The controls were healthy people matched by age, sex, and education years. We assessed the differences in a battery of neuropsychological tests between the two groups, investigated the diffusion changes in 40 WM tracts among the participantsviaan atlas-based segmentation strategy, and compared the differences between the cases and controls by multiple linear regression analysis. We then evaluated the relationships between diffusion indices and cognitive assessment scores by Pearson’s correlation.ResultsThe pre-SVCI group exhibited significant differences in the Montreal cognitive assessment (MoCA), Rey–Osterrieth Complex Figure (R-O)-copy, and Trail Making Test (TMT)-B test compared with the controls. Compared with the controls, some long associative and projective bundles, such as the right anterior corona radiata (ACR), the right inferior fronto-occipital fasciculus (IFOF), and the left external capsule (EC), were extensively damaged in cases after Bonferroni correction (p&lt; 0.05/40). Damages to specific fibers, such as the right ACR, IFOF, and posterior thalamic radiation (PTR), exhibited significant correlations with declines in MoCA, R-O delay, and the Mini-Mental State Examination (MMSE), respectively, after Bonferroni correction (p&lt; 0.05/14).ConclusionLong WM tracts, especially those in the right hemisphere, were extensively damaged in the pre-SVCI patients and correlated with declines in executive functions and spatial processing. Patients of pre-SVCI are likely at an ultra-early stage of SVCI, and there is a very high risk of this condition becoming SVCI.
The Efficacy of Intraoperative Passive Language Mapping for Glioma Surgery: A Case Report
Authors: Kanaya Kohei , Mitsuhashi Takumi , Kiuchi Takafumi , Kobayashi Sumio 
Published: August 2021

Background: Recently, electrocorticographic (ECoG) studies have emphasized the importance of gamma band-based functional mapping in the presurgical localization of the eloquent cortex. Passive functional mapping using ECoG signals provides a reliable method for identifying receptive language areas without many of the risks and limitations associated with electrical cortical stimulation. We report a surgical case of left temporal malignant glioma with intraoperative passive language mapping.Case Description: A 78-year-old woman was diagnosed with left temporal glioma with inspection of her language difficulty. MRI showed a left temporal tumor measuring 74.6 × 50.0 × 51.5 mm in size. Real-time CortiQ-based mapping using high-gamma activity by word-listening and story-listening tasks was performed. Significant listening task-evoked high gamma activities were detected in 5 channels in the superior temporal gyrus and one channel in the middle temporal gyrus. The tumor was grossly removed except for the region corresponding to listening task-evoked high gamma activities. Postoperatively, the patient's symptoms of language comprehension difficulty improved, and no new neurological deficits were observed.Conclusion: Intraoperative passive language mapping was successfully performed, and the patient's language function was well-preserved. Intraoperative passive language mapping, which is applicable in a short time and under general anesthesia, can be an important tool for detecting language areas.
Development of a tRNA-Derived Small RNA Prognostic Panel and Their Potential Functions in Osteosarcoma
Authors: Tang Zhenming , Zhang Shuhui , Ling Zhougui 
Published: August 2021

BackgroundTherapeutic outcomes of osteosarcoma treatment have not significantly improved in several decades. Therefore, strong prognostic biomarkers are urgently needed.MethodsWe first extracted the tRNA-derived small RNA (tsRNA) expression profiles of osteosarcoma from the GEO database. Then, we performed a unique module analysis and use the LASSO-Cox model to select survival-associated tsRNAs. Model effectiveness was further verified using an independent validation dataset. Target genes with selected tsRNAs were predicted using RNAhybrid.ResultsA LASSO-Cox model was established to select six prognostic tsRNA biomarkers: tRF-33-6SXMSL73VL4YDN, tRF-32-6SXMSL73VL4YK, tRF-32-M1M3WD8S746D2, tRF-35-RPM830MMUKLY5Z, tRF-33-K768WP9N1EWJDW, and tRF-32-MIF91SS2P46I3. We developed a prognostic panel for osteosarcoma patients concerning their overall survival by high-low risk. Patients with a low-risk profile had improved survival rates in training and validation dataset.ConclusionsThe suggested prognostic panel can be utilized as a reliable biomarker to predict osteosarcoma patient survival rates.
Identification of Tumor Microenvironment-Related Prognostic lncRNAs in Lung Adenocarcinoma
Authors: Yuan Ligong , Li Feng , Wang Shuaibo , Yi Hang , Li Fang , Mao Yousheng 
Published: August 2021

BackgroundLung adenocarcinoma (LUAD) is the most common type of lung cancer and is a severe threat to human health. Although many therapies have been applied to LUAD, the long-term survival rate of patients remains unsatisfactory. We aim to find reliable immune microenvironment-related lncRNA biomarkers to improve LUAD prognosis.MethodsESTIMATE analysis was performed to evaluate the degree of immune infiltration of each patient in TAGA LUAD cohort. Correlation analysis was used to identify the immune microenvironment-related lncRNAs. Univariate cox regression analysis, LASSO analysis, and Kaplan Meier analysis were used to construct and validate the prognostic model based on microenvironment-related lncRNAs.ResultsWe obtained 1,178 immune microenvironment-related lncRNAs after correlation analysis. One hundred and eighty of them are independent prognostic lncRNAs. Sixteen key lncRNAs were selected by LASSO method. This lncRNA-based model successfully predicted patients’ prognosis in validation cohort, and the risk score was related to pathological stage. Besides, we also found that TP53 had the highest frequency mutation in LUAD, and the mutation of TP53 in the high-risk group, which was identified by our survival model, has a poor prognosis. lncRNA-mRNA co-expression network further suggested that these lncRNAs play a vital role in the prognosis of LUAD.ConclusionHere, we filtered 16 key lncRNAs, which could predict the survival of LUAD and may be potential biomarkers and therapeutic targets.
Case Report: Remdesivir and Convalescent Plasma in a Newly Acute B Lymphoblastic Leukemia Diagnosis With Concomitant Sars-CoV-2 Infection
Authors: Dell'Isola Giovanni Battista , Felicioni Matteo , Ferraro Luigi , Capolsini Ilaria , Cerri Carla , Gurdo Grazia , Mastrodicasa Elena , Massei Maria Speranza , Perruccio Katia , Brogna Mariangela , Mercuri Alessandra , Pasqua Barbara Luciani , Gorello Paolo , Caniglia Maurizio , Verrotti Alberto , Arcioni Francesco 
Published: August 2021

Introduction:The spread of Covid-19 has worsened the prognosis of oncology patients, interrupting or delaying life-saving therapies and contextually increasing the risk of severe SARS-CoV-2 infections. Acute lymphoblastic leukemia (ALL) is the most frequent cancer in pediatric age and the management of this disease with concomitant SARS-COV-2 infection represents a challenging situation.Case presentation:We present the case of a 6-year-old female newly diagnosed with ALL during a documented SARS-CoV-2 infection. Our patient was admitted 20 days after SARS-CoV-2 detection for evening-rise fever. Laboratory testing showed severe neutropenia while chest x-ray detected moderate pulmonary involvement. Acute lymphoblastic leukemia diagnosis was made through morphological and molecular analysis on bone marrow aspirate. Given the stability of the blood count and clinical conditions, antiviral therapy with Remdesivir and Convalescent Plasma was started before antileukemic treatment, obtaining a rapid resolution of the infection.Conclusion:In our experience, the treatment with Remdesivir and Convalescent Plasma led to a rapid resolution of Sars-Cov-2 infection. Our case did not present any adverse event to the therapy. Thus, this treatment could be considered in patients with malignancies, in order to accelerate the resolution of the infection and begin immunosuppressive treatment safely. Further studies are required to confirm this hypothesis.
Attending a Biopsychosocially Focused Buprenorphine Training Improves Clinician Attitudes
Authors: Russell Holly Ann , Smith Brian , Sanders Mechelle , Loomis Elizabeth 
Published: August 2021

Objective: Substance use disorders remain highly stigmatized. Access to medications for opioid use disorder is poor. There are many barriers to expanding access including stigma and lack of medical education about substance use disorders. We enriched the existing, federally required, training for clinicians to prescribe buprenorphine with a biopsychosocial focus in order to decrease stigma and expand access to medications for opioid use disorder.Methods: We trained a family medicine team to deliver an enriched version of the existing buprenorphine waiver curriculum. The waiver training was integrated into the curriculum for all University of Rochester physician and nurse practitioner family medicine residents and also offered to University of Rochester residents and faculty in other disciplines and regionally. We used the Brief Substance Abuse Attitudes Survey to collect baseline and post-training data.Outcomes: 140 training participants completed attitude surveys. The overall attitude score increased significantly from pre to post-training. Additionally, significant changes were observed in non-moralism from pre-training (M = 20.07) to post-training (M = 20.98, p &lt; 0.001); treatment optimism from pre-training (M = 21.56) to post-training (M = 22.33, p &lt; 0.001); and treatment interventions from pre-training (M = 31.03) to post-training (M = 32.10, p &lt; 0.001).Conclusion: Increasing medical education around Opioid Use Disorder using a Family Medicine trained team with a biopsychosocial focus can improve provider attitudes around substance use disorders. Enriching training with cases may improve treatment optimism and may help overcome the documented barriers to prescribing medications for opioid use disorder and increase access for patients to lifesaving treatments.
Effectiveness of an Individual Cognitive-Behavioral Intervention for Serious, Young Male Violent Offenders: Randomized Controlled Study With Twenty-Four-Month Follow-Up
Authors: Lardén Martin , Högström Jens , Långström Niklas 
Published: August 2021

Background:Psychological recidivism-reducing interventions with serious, young violent offenders in residential care have unsatisfactory effects. We tested if a complementary individual cognitive behavioral therapy (iCBT) intervention focusing problem-solving, cognitive self-control, and relapse prevention reduces criminal recidivism beyond usual institutional care encompassing interventions such as social skills training and prosocial modeling (treatment-as-usual; TAU).Method:We consecutively approached 115 eligible serious, male violent crime offenders in five residential treatment homes run by the Swedish National Board of Institutional Care. Eighty-one (70%) 16 to 21-year-old youth at medium-high violent recidivism risk were included and randomized to an individualized 15 to 20-session CBT intervention plus TAU (n= 38) or to TAU-only (n= 43), 4–6 months before release to the community. Participants were assessed pre- and post-treatment, at 12 months (self-reported aggressive behavior, reconvictions) and 24 months (reconvictions) after release. Intent-to-treat analyses were applied.Results:The violent reconviction rate was slightly higher for iCBT+TAU vs. TAU-only youth at 12 months (34 vs. 23%,d= 0.30, 95% CI: −0.24 to 0.84) and 24 months following release (50 vs. 40%,d= 0.23, 95% CI: −0.25 to 0.72), but neither of these differences were significant. Cox regression modeling also suggested non-significantly, negligibly to slightly more violent, and any criminal recidivism in iCBT+TAU vs. TAU-only youth during the entire follow-up. Further, we found no significant between-group differences in conduct problems, aggression, and antisocial cognitions, although both iCBT+TAU and TAU-only participants reported small to large within-group reductions across outcome measures at post-treatment. Finally, the 12-month follow-up suggested marginally more DSM-5 Conduct Disorder (CD) symptoms of “aggression to people and animals” in iCBT+TAU vs. TAU-only youth (d= 0.10, 95% CI: −0.40 to 0.60) although this difference was not significant.Conclusion:We found no additive effect of individual CBT beyond group-based TAU in residential psychological treatment for serious, young male violent offenders. Limited sample size and substantial treatment dropout reduced the robustness of intent-to-treat effect estimates. We discuss the possible impact of treatment dose and integrity, participant retention, and TAU quality.
Arabidopsis G-Protein β Subunit AGB1 Negatively Regulates DNA Binding of MYB62, a Suppressor in the Gibberellin Pathway
Authors: Qi Xin , Tang Wensi , Li Weiwei , He Zhang , Xu Weiya , Fan Zhijin , Zhou Yongbin , Wang Chunxiao , Xu Zhaoshi , Chen Jun , Gao Shiqin , Ma Youzhi , Chen Ming 
Published: August 2021

Plant G proteins are versatile components of transmembrane signaling transduction pathways. The deficient mutant of heterotrimeric G protein leads to defects in plant growth and development, suggesting that it regulates the GA pathway in Arabidopsis. However, the molecular mechanism of G protein regulation of the GA pathway is not understood in plants. In this study, two G protein β subunit (AGB1) mutants, agb1-2 and N692967, were dwarfed after exogenous application of GA3. AGB1 interacts with the DNA-binding domain MYB62, a GA pathway suppressor. Transgenic plants were obtained through overexpression of MYB62 in two backgrounds including the wild-type (MYB62/WT Col-0) and agb1 mutants (MYB62/agb1) in Arabidopsis. Genetic analysis showed that under GA3 treatment, the height of the transgenic plants MYB62/WT and MYB62/agb1 was lower than that of WT. The height of MYB62/agb1 plants was closer to MYB62/WT plants and higher than that of mutants agb1-2 and N692967, suggesting that MYB62 is downstream of AGB1 in the GA pathway. qRT-PCR and competitive DNA binding assays indicated that MYB62 can bind MYB elements in the promoter of GA2ox7, a GA degradation gene, to activate GA2ox7 transcription. AGB1 affected binding of MYB62 on the promoter of GA2ox7, thereby negatively regulating th eactivity of MYB62.
Post-Treatment Status of Impacted Maxillary Central Incisors following Surgical-Orthodontic Treatment: A Systematic Review
Authors: Žarovienė Alvyda , Grinkevičienė Dominyka , Trakinienė Giedrė , Smailienė Dalia 
Published: August 2021

Background and Objectives: The aim of this systematic review was to summarize currently available data of published articles that have investigated the post-treatment status of impacted maxillary central incisors (ICI) treated by the surgical-orthodontic approach. Materials and Methods: MEDLINE, Scopus, Cochrane Oral Health Group’s Trials Register, and ScienceDirect electronic databases were systematically searched with no publication date restrictions up to January 2021. Data assessing the status of ICI after combined surgical-orthodontic treatment and forced eruption duration were extracted, and the quality of the studies was evaluated. Results: In total, 7074 studies were identified, of which 42 articles were assessed for eligibility through full-text evaluation. Seven included studies (five retrospective studies, one randomized clinical trial, and one prospective clinical trial) met the inclusion criteria, representing 211 patients with unilaterally impacted maxillary incisors. The risk of bias ranged from moderate to high. The results show that the root length of immature ICIs increased significantly but remained shorter than that of homonym teeth at post-treatment. Periodontal parameters of treated ICIs were in a clinically acceptable range. Measurements of the alveolar bone showed a reduction of bone thickness and support. The average forced eruption duration ranged from 8.0 ± 4.5 to 14.41 ± 4.03 months. Conclusions: Based on existing evidence, it is reasonable to conclude that the surgical-orthodontic treatment affected the post-treatment status of ICI; however, the current literature is insufficient to draw concrete conclusions. Further well-conducted multi-center randomized studies with a large sample are needed to confirm this statement.
Perancangan Prototipe Sistem Pendaftaran Online Rumah Sakit Untuk Pelayanan Poli Berbasis Android
Authors: Siagian Saut Horas Tua , Amri Imti Tsalil , Santoso Santoso 
Published: August 2021

RSUD H. Abdul Manap adalah rumah sakit milik pemerintah daerah kota Jambi yang terus berupaya untuk meningkatkan layanan serta standar kualitas rumah sakit dari berbagai sisi, antara lain pemanfaatan teknologi informasi. Proses Pendaftaran pasien pada Rumah Sakit ini masih dilakukan dengan model konvensional sehingga dengan tingkat kunjungan yang tinggi kadangkala terjadi penumpukan di ruang tunggu Front Office. Dengan tingginya tingkat pendaftaran tersebut, maka berdampak pula pada tingkat antrian yang tinggi pada pelayanan poliklinik Rumah Sakit. Kadangkala pasien sampai menunggu di luar ruang tunggu poliklinik, sehingga ada pasien yang tidak mendengar ketika namanya dipanggil dan menyebabkan namanya dilewatkan serta tidak mengetahui nomor urutan yang telah dipanggil. Tujuan dari penelitian ini adalah merancang purwarupa sistem pendaftaran online rumah sakit untuk pelayanan poli berbasis android, dimana di dalam sistem pendaftaran tersebut terdapat pula layanan antrian untuk poliklinik. Metodologi yang digunakan dalam perancangan ini adalah dengan melakukan identifikasi masalah, studi literatur, pengumpulan data, prototyping modeling dan penulisan laporan. Penelitian ini menghasilkan sebuah prototype sistem pendaftaran online rumah sakit untuk pelayanan poli berbasis android yang mengolah sistem pendaftaran dan antrian pada layanan poliklinik Rumah Sakit Umum Daerah H. Abdul Manap Kota Jambi, sehingga dapat mengurangi permasalahan pada model konvensional sebelumnya
Perancangan Sistem Informasi Pelayanan Travel Haji Dan Umroh
Authors: Arvita Yulia 
Published: August 2021

Selama ini pada travel haji dan umroh kegiatan bisnisnya masih menggunakan sistem konvensional yang banyak kekurangannya ditengah tuntutan penggunaan teknologi informasi. Hal ini mengakibatkan kegiatan bisnis pada travel ini tidak bisa dijalankan secara optimal dalam mengelola dan mengakses informasi dan menarik data calon jamaah haji dan umroh. Untuk memberikan pelayanan terbaik kepada calon jamaah maka dirancanglah sebuah sistem informasi pelayanan haji dan umroh. Penelitian ini menghasilkan sebuah prototype sistem informasi pelayanan haji dan umroh dengan fitur calon jamaah dapat melihat informasi mengenai paket haji dan umroh, jadwal manasik dan bisa mendaftar haji dan umroh melalui sistem tersebut sedangkan untuk karyawan memudahkan pengelolaan administratif calon jamaah haji dan umroh dan juga dapat membantu membuat laporan secara cepat singkat akurat dan tepat guna memberikan pelayanan terbaik kepada calon jamaah haji dan umroh.
Analisis Rasio Pada Akun Youtube Untuk Penelitian Kualitatif Menggunakan Metode Ekploratif
Authors: Hendika Permana I Putu 
Published: August 2021

Teknologi informasi dan komunikasi saat ini telah berkembang dengan pesat, hal ini membuat semakin banyak jenis aplikasi sosial media yang muncul dengan fitur dan fungsi yang berbeda-beda. Salah satu aplikasi sosial media yang sering digunakan dan memiliki pengaruh besar adalah YouTube. Penelitian ini dilakukan dengan tujuan untuk menemukan rasio-rasio yang terdapat pada akun YouTube. Rasio-rasio ini yang nantinya akan digunakan untuk mengukur performa sebuah akun secara matematis. Penelitian ini dilakukan dengan menggunakan metode ekploratif untuk menemukan variabel-variabel yang terdapat pada akun YouTube. Variabel tersebut yang nantinya akan dibandingkan dan disandingkan untuk diuji relevansinya sehingga menjadi rasio yang relevan. Rasio yang relevan akan digunakan untuk menilai performa setiap akun yang ada pada sosial media YouTube. Hasil dari penelitian sosial media youtube ini menunjukan bahwa terdapat 6 variabel, variabel tersebut diantaranya yaitu post, subscriber, likes, dislikes, viewers, comments. Keenam variabel tersebut yang nantinya akan dibandingkan dan disandingkan sehingga menemukan 10 rasio yang relevan. Manfaat yang dapat diambil dari penelitian ini yaitu kedepannya dapat menilai, mengukur serta membandingkan kredebilitas dari setiap akun youtube dengan mudah menggunakan 10 rasio yang telah ditemukan.