bluuebunny/crossref_metadata_2025_split huggingface dataset:
Industrielle Produktionsanlagen modular erweitern mit 5G
Authors: Schmitt Sarah , Brunk Nicolas , König Niels , Lange Dirk , Schmitt Robert H. 
Published: May 2021

Abstract
Erstmalig erhält eine Mobilfunktechnologie Einzug in die Industrie: Mit hoher Übertragungsbandbreite und geringer Latenz erfüllt 5G die Anforderungen industrieller Netzwerke und ebnet den Weg für neue Geschäftsmodelle zur Steigerung der betrieblichen Effizienz. Durch kabellose, modulare Sensorkonzepte können innovative Anwendungsszenarien realisiert und der stetig wachsende Bedarf der Industrie nach immer flexibleren Produktionsanlagen gedeckt werden.
Anpassung von Produktionssystemen an die Auswirkungen des Klimawandels
Authors: Ehmsen Svenja , Werrel Max , Aurich Jan C. 
Published: May 2021

Abstract
Die Folgen des voranschreitenden Klimawandels wie Hitze- und Dürreperioden, Starkregen und Stürme treten immer häufiger und in steigender Intensität auf. Sie gefährden mitunter Produktionsprozesse in Unternehmen und verursachen dabei hohe Schadenskosten. Daher kommt der Anpassung an die Klimawandelfolgen für produzierende Unternehmen eine zunehmend große Bedeutung zu. Dieser Beitrag stellt ein Konzept vor, wie Unternehmen zukünftig die für ihr Produktionssystem relevanten Klimawandelfolgen identifizieren und geeignete Anpassungsmaßnahmen bestimmen können.
Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations
Authors: Malaiya Sonia , Cortes-Gutierrez Marcia , Herb Brian R. , Coffey Sydney R. , Legg Samuel R. W. , Cantle Jeffrey P. , Colantuoni Carlo , Carroll Jeffrey B. , Ament Seth A. 
Published: May 2021

Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs primarily in striatal medium spiny neurons (MSNs), but the involvement of specific MSN subtypes and of other striatal cell types remains poorly understood. To gain insight into cell type-specific disease processes, we studied the nuclear transcriptomes of 4524 cells from the striatum of a genetically precise knock-in mouse model of the HD mutation,HttQ175/+, and from wild-type controls. We used 14- to 15-month-old male mice, a time point at which multiple behavioral, neuroanatomical, and neurophysiological changes are present but at which there is no known cell death. Thousands of differentially expressed genes (DEGs) were distributed across most striatal cell types, including transcriptional changes in glial populations that are not apparent from RNA-seq of bulk tissue. Reconstruction of cell type-specific transcriptional networks revealed a striking pattern of bidirectional dysregulation for many cell type-specific genes. Typically, these genes were repressed in their primary cell type, yet de-repressed in other striatal cell types. Integration with existing epigenomic and transcriptomic data suggest that partial loss-of-function of the polycomb repressive complex 2 (PRC2) may underlie many of these transcriptional changes, leading to deficits in the maintenance of cell identity across virtually all cell types in the adult striatum.SIGNIFICANCE STATEMENTHuntington's disease (HD) is a dominantly inherited neurodegenerative disorder characterized by specific loss of medium spiny neurons (MSNs) in the striatum, accompanied by more subtle changes in many other cell types. It is thought that changes in transcriptional regulation are an important underlying mechanism, but cell type-specific gene expression changes are not well understood, particularly at time points relevant to the onset of disease-related symptoms. Single-nucleus (sn)RNA-seq in a genetically precise mouse model enabled us to identify novel patterns of transcriptional dysregulation because of HD mutations, including bidirectional dysregulation of many cell type identity genes that may be driven by partial loss-of-function of the polycomb repressive complex (PRC). Identifying these regulators of transcriptional dysregulation in HD can be leveraged to design novel disease-modifying therapeutics.
Observing and Modeling the Pacific Ocean [Video]
Authors: Washburn Libe 
Published: May 2021

Marine scientists incorporate a wide array of observations and models to understand the oceans, their dynamics, and the life they support. The development of new sensing technologies such as satellites, gliders, and robotic floats, as well as increasing public interest and funding for projects to investigate the ocean’s role in climate change, has transformed marine sciences into “big data” sciences. But the observational scientist still faces numerous obstacles in measuring ocean characteristics such as sea surface height, currents, temperature, salinity, water color, ocean chemistry, and undersea life: electromagnetic radiation does not readily penetrate its waters, which makes it harder to conduct observations and communicate with underwater instruments, and because oceans are full of life, so called “biofouling” is a challenge to observing, especially in the sun-lit layers near the surface. Nevertheless, new technologies such as robotic vehicles and new sensors are enabling observations throughout the ocean water column. These technologies, coupled with rapidly advancing ocean models, are revolutionizing our understanding of the marine biosphere. [Image: UCSB undergraduates Andie Rupprecht and Sean Jawetz recover a robotic stand-up paddle board used for measuring ocean currents. Photograph by Libe Washburn.] <br> Video available: https://vimeo.com/527397347
Chromosomal instability by mutations in the novel minor spliceosome component CENATAC
Authors: de Wolf Bas , Oghabian Ali , Akinyi Maureen V , Hanks Sandra , Tromer Eelco C , van Hooff Jolien J E , van Voorthuijsen Lisa , van Rooijen Laura E , Verbeeren Jens , Uijttewaal Esther C H , Baltissen Marijke P A , Yost Shawn , Piloquet Philippe , Vermeulen Michiel , Snel Berend , Isidor Bertrand , Rahman Nazneen , Frilander Mikko J , Kops Geert J P L 
Published: May 2021

AbstractAneuploidy is the leading cause of miscarriage and congenital birth defects, and a hallmark of cancer. Despite this strong association with human disease, the genetic causes of aneuploidy remain largely unknown. Through exome sequencing of patients with constitutional mosaic aneuploidy, we identified biallelic truncating mutations in CENATAC (CCDC84). We show that CENATAC is a novel component of the minor (U12‐dependent) spliceosome that promotes splicing of a specific, rare minor intron subtype. This subtype is characterized by AT‐AN splice sites and relatively high basal levels of intron retention. CENATAC depletion or expression of disease mutants resulted in excessive retention of AT‐AN minor introns in ˜ 100 genes enriched for nucleocytoplasmic transport and cell cycle regulators, and caused chromosome segregation errors. Our findings reveal selectivity in minor intron splicing and suggest a link between minor spliceosome defects and constitutional aneuploidy in humans.
Razvoj znanstvenog polja metalurgije u Republici Hrvatskoj u razdoblju od 1960. do 2020. godine
Authors: Gojić Mirko 
Published: May 2021

U ovom radu naveden je razvoj znanstvenog polja metalurgije u području tehničkih znanosti u Republici Hrvatskoj (RH) u razdoblju od 1960. do 2020. godine. Razvoj metalurgije odvijao se na Metalurškom odjelu (1960. – 1974.) i Metalurškom inženjerstvu Tehnološkog fakulteta Sveučilišta u Zagrebu (1974. – 1978.), Institutu za lake metale u Zagrebu (1949. – 1968.), Institutu za metalurgiju u Sisku (1961. – 1978.), Metalurškom fakultetu u okviru Željezare Sisak (1979. – 1991.) i na Metalurškom fakultetu kao samostalnoj sastavnici Sveučilišta u Zagrebu (1991. –). Razvoj polja metalurgije usko je vezan s metalurškom industrijom u RH (Željezara Sisak, Tvornica lakih metala Šibenik, brojne ljevaonice itd.) i stručnim knjižnicama. Prikazana je nastavna, znanstveno-istraživačka i stručna aktivnost te izdavačka i publicistička djelatnost u znanstvenom polju metalurgije. Naveden je i kratki prikaz doprinosa polju metalurgije i drugih visokoškolskih institucija i stručnih društava. U tom razdoblju (do 31. 12. 2019. godine) stečena su 763 akademska zvanja i 34 akademska stupnja doktora znanosti iz polja metalurgije na Sveučilištu u Zagrebu i u RH. U razdoblju 1960. – 2020. objavljeno je više od 3000 znanstvenih i stručnih radova u domaćim i međunarodnim časopisima i zbornicima međunarodnih i domaćih konferencija. Kao rezultat stručnih aktivnosti izrađeno je više od 1000 studija i elaborata, velik broj stručnih izvještaja za gospodarske subjekte iz metalurgije i srodnih znanstvenih polja, registrirano je oko 20-ak patenata itd. U tom razdoblju u polju metalurgije tiskano je nekoliko monografija, više od 50 knjiga i sveučilišnih udžbenika, sedam zbornika cjelovitih radova (1999. – 2006.) i jedanaest zbornika sažetaka (2008. – 2019.) međunarodnog savjetovanja ljevača, brojne sveučilišne i interne skripte itd.
Early arteriosclerosis and its risk factors in subjects with prediabetes and new-onset diabetes
Authors: Liu Xiaoli , Liu Lanxiang , Wang Rui , Jia Xiaojiao , Liu Binbin , Ma Ning , Lu Qiang 
Published: May 2021

Background
We aimed to investigate early arteriosclerosis and its risk factors in populations with prediabetes and new-onset diabetes.

Materials and methods
A total of 148 participants who did not have diabetes mellitus were assigned to three groups through an oral glucose tolerance test: the normal glucose tolerance (NGT) group; the impaired glucose regulation, also known as prediabetes group and the new-onset type 2 diabetes mellitus group. The insulin resistance index was assessed using the homeostatic model assessment of insulin resistance (HOMA-IR). An ELISA was used to determine the level of fibroblast growth factor 21 (FGF21). An arteriosclerosis detector was used to measure the brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI). The baPWV, ABI, and FGF21 were used to assess early arteriosclerosis.

Results
Significant differences in age, systolic blood pressure (SBP), fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), 2-h insulin (2hINS), and HOMA-IR were found between the NGT group and the prediabetes and new-onset diabetes groups. All of the above, except 2hINS, showed an increasing trend. Moreover, the FGF21 was higher in the new-onset diabetes group than in the NGT group. The baPWV was higher in the new-onset diabetes group than in the other two groups, but no significant difference was noted in the ABI. Age, SBP, diastolic blood pressure, FPG, 2hPG, and FGF21 were positively correlated with the baPWV. In addition, FPG, SBP, FGF21, and HOMA-IR were independent risk factors for the baPWV.

Conclusions
Patients with prediabetes and new-onset diabetes may have more significant early arteriosclerosis. The blood glucose level and insulin resistance index may be independent risk factors for early arteriosclerosis.
The Paradoxes of Person – Some Remarks
Authors: Mazur Piotr Stanisław 
Published: May 2021

The goal of the article is to present and analyze the paradoxes of person in the historical, logical-epistemological, and systematic aspect. Their historical source should be sought already in the beginnings of philosophical reflection on the issue of personhood. The interpretation of this concept has been influenced by the Christian religion which contributed to highlighting the opposition between properties common to man and other beings, and those which distinguish him from those beings. It was finally reflected in the paradoxes of person which are construed today as the opposition between existence (being a person) and becoming; (ontic) non-communicability and (intentional) communicability; overtness (knowability) and covertness (essential unknowability); being a whole and being a part. These paradoxes, however, are not antinomies or paralogisms in the logical sense. They cannot be explained away by flaws in human thinking or cognition. They are an expression of the opposite properties of personhood which represent aporias – objective difficulties. As such, they arise from the way a person exists. The paradoxes of person are superimposed, so to say, onto the paradoxes of being, e.g. that of identity and change. They cannot be interpreted as compounds of being. Therefore, they are most often treated as a result of the complex, spiritual-corporeal structure of man. Another problem, just as important as the cause of paradoxes, is the question of their significance. For they may be interpreted as a manifestation of a way of personal being that extends between extreme (almost contradictory) poles; multifaceted, diverse, never limited only to the arrangement of particular properties which form the paradoxes, or to that which can be known through them.
Why is it so rare and random to find pyre sites?
Authors: Fülöp Kristóf 
Published: May 2021

The cremation rite is well-defined in space and time as it is the central part of a series of complex ritual events. Although it is one of the most significant and representative elements of the funeral, yet we know very little about it due to its destructive nature, the scarcity of pyre sites and the indirect character of cremated bones and artefacts found in graves. The two experimental cremations presented in this article, on the one hand, address this rare occurrence of pyre sites. On the other hand, by the detailed documentation of the cremation process and the formation of pyre sites, it is possible to examine in detail several new issues related to the pyre sites. Thus, the shape, orientation, dimension, and structure of the funeral pyre, as well as some moments of the cremation are discussed in detail. Furthermore, the representation of the body and pyre goods after the pyre’s burndown, the movement of artefacts during burning, and the watering of pyre remains, as well as the problem of the mixture are also examined. At the same time, the experimental observations also draw attention, besides the investigational possibilities, to the archaeological limitations of pyre sites.
Pre-Scythian burial in Tiszakürt
Authors: Mogyorós Péter 
Published: May 2021

During its long history, humanity left traces everywhere, therefore it is inevitable that finds, hoards or burials are going to be found accidentally besides professional excavations. That kind of a discovery occurred in Tiszakürt (Hungary), where a grave of the Mezőcsát group has been found.In this paper the three vessels – two urns and a beaker – of the grave will be presented. We do not have the skeleton, however, we do have an exquisite description of the grave. This description is important since it allows us to examine the burial practice as well.
Öcsöd-Kováshalom. Potscape of a Late Neolithic site in the Tisza region
Authors: Füzesi András , Raczky Pál 
Published: May 2021

The primary goal of the present study is the publication of the ceramic inventory from Öcsöd-Kováshalom, for which Dissertationes Archaeologicae, being an online journal, can provide the necessary space. We shall principally focus on the possible correlations between vessel forms and their decoration in our analysis, alongside the examination of other traits and dimensions. The ad hoc nature of the analysed finds, i.e. an assemblage of vessels that could be successfully refitted, nevertheless constrains the more general insights that can be drawn from this assemblage. Our primary focus is on three different groups of the site’s ceramic inventory, examined according to uniform criteria. The analytical units differ from each other in terms of size and, as a result, the quality of the recorded data. Until now, the so-called Tisza I and Tisza II cultural phases were essentially distinguished qualitatively, based on the differing ceramic style of the two superimposed occupationlevels (A and B) at Öcsöd-Kováshalom. We took a bottom-up approach in our analysis, moving from the deposits of individual contexts towards the entirety of the settlement. We also strove to extend the Tisza I and II developmental sequence to a larger region in the southern Hungarian Plain by looking at the contexts with similar ceramic patterns on other sites. The essence of our approach is encapsulated by Katalin Sebők’s model for the Late Neolithic of the Tisza region, in which ceramic vessels are enveloped by the different (research) aspect connected with several lines, reflecting the intricate relationships between them. This model takes stock of both the European and the American theoretical approaches and also incorporates elements of various approaches based on system and network theories that figure prominently in modern research agendas. Another inspiring aspect of K. Sebők’s initiative is that she moved beyond the traditional boundaries of pottery assessment and sought new avenues for meaningful analyses, which was also one of our priorities in the current assessment of the pottery finds from Öcsöd-Kováshalom. The settlement complex represents a specific initial phase in the Late Neolithic development of the Hungarian Plain in the Tiszazug micro-region. Its position in the Tisza culture’s formative phase determined the nature of the site, made up of a tell-like and a single-layer settlement, and its layout of a central settlement area surrounded by smaller settlement clusters within a large triple and segmented enclosure, as well as the community’s social and economic milieu. The finds and features brought to light at the site preserve the imprints of complex, multi-scalar processes in the community’s life. The main goal of the analysis of the assemblage of 240 refitted and reconstructed vessels was to examine and interpret the possible imprints of these multi-level changes.
‘All that glitters is not Roman’ - Roman coins discovered in East Java, Indonesia
Authors: Hoppál Krisztina , Vida István , Adhityatama Shinatria , Yahui Lu 
Published: May 2021

Studying extra regional trade networks in Antiquity can be considered a relatively popular field of research, but the intensity and patterns of such complex system still leave lot of questions, particularly in the case of Rome’s Far Eastern trade. There is still a trend to visualize a kind of globalized commercial activity between the Imperium and communities on the eastern edge of the Silk Road(s). However, the facts provide us a more comprehensive picture. Due to the meticulous work of international joint research projects working in East and Southeast Asia followed by a raised interest in collecting ancient objects among local people, an increasing number of Roman objects have been discovered in the region. These finds prove the significance of mediator cultures in transferring Roman artifacts beyond India – with their own imprints on forming evaluation/acceptance of these non-local goods by the receiving culture.
Preliminary report on the excavation at Andornaktálya-Marinka in 2018
Authors: Mester Zsolt , Cserpák Ferenc , Faragó Norbert 
Published: May 2021

Andornaktálya-Marinka is among the several Palaeolithic archaeological sites in the region of Eger, on the foothills of the Bükk Mountains, North-Eastern Hungary. It is situated on the top of a 234 m high elevation located between the villages Andornaktálya and Ostoros. The site was discovered in 2014 by Ferenc Cserpák. Surface collections yielded by several field surveys show two kinds of archaeological material: one is signified mostly by a bifacial-like industry made of quartz porphyry (metarhyolite), while the other one is abundant in blade-like pieces made of Silesian erratic flint. The main aim of the excavation carried out in summer 2018 was to obtain stratigraphic information about the position of the industries, as well as to characterize the quaternary sediments covering the hilltop. The artefacts unearthed in the five trenches occurred in a depth of 60 to 80 cm in a brown chernozem-like layer.
Preliminary report on the excavation of the site Tiszakürt-Zsilke-tanya
Authors: Fülöp Kristóf , Lönhardt Denisa M. , Szabó Nóra , Váczi Gábor 
Published: May 2021

Colleagues of the Institute of Archaeological Sciences of the Eötvös Loránd University performed a rescue excavation at the site of Tiszakürt-Zsilke-tanya in 2018, within the series of excavations preceding the construction of the M44 motorway. Neolithic, Sarmatian, and Avar Age settlement sections and burials came to light on the hills situated on the left bank of the Tisza River. This preliminary report presents their most important finds and phenomena.
Recent excavations at the medieval castle of Bánd
Authors: Nagy Szabolcs Balázs 
Published: May 2021

After the first minor investigations between 1997 and 2007 a new series of excavations have been conducted at the medieval castle of Bánd in 2013, 2017 and 2018.1 Although the scale of the latest works is still quite moderate compared to the dimensions of the fortification, the observations resulted not only in considerable amounts of find material but also in objects that raised important issues and unexpected questions. The archaeological evidence proves a special relationship between the castle and the medieval settlement(s) of Bánd, the details of which definitely call for further research.
İLKÖĞRETİM ÖĞRENCİLERİNİN ÖZGÜRLÜK DEĞERİNE İLİŞKİN TUTUMLARI
Authors: KAYA Fatih , AKPINAR Erdal 
Published: May 2021

Bu çalışmanın amacı, ilköğretim öğrencilerinin özgürlük değerine ilişkin tutumlarını belirlemektir. Araştırmada karma yöntem tasarımlarından, açıklayıcı sıralı desen kullanılmıştır. Bu desende araştırma nicel ile başlayıp, nitel ile devam eder. Araştırmanın çalışma grubu, nicel ve nitel süreçler için ayrı ayrı belirlenmiştir. Araştırma evreni, 2019-2020 öğretim yılında Malatya il merkezindeki ilkokul ve ortaokullarda sosyal bilgiler dersinin okutulduğu sınıflardır. Araştırmanın örneklemini ise, bu evrenden basit seçkisiz örnekleme yolu ile belirlenen 1249 öğrenci oluşturmaktadır. Araştırmanın nitel verileri, amaçlı örnekleme yöntemlerinden olan maksimum çeşitlilik örneklem türü ile elde edilmiştir. Bu kapsamda toplam 24 öğrenci araştırmaya katılmıştır.
Araştırmanın nicel verileri Sosyal Bilgiler ile İnsan Hakları, Yurttaşlık ve Demokrasi Dersi Değerlerine İlişkin Tutum Ölçeği, nitel verileri ise yarı yapılandırılmış görüşme formu ile toplanmıştır. Görüşme formunda öğrencilere; “Özgürlük sizin için neyi ifade ediyor?” sorusu yöneltilmiştir. Nicel veriler betimsel ve çıkarımsal istatistiki yöntemler, nitel veriler ise içerik analizi yöntemi ile analiz edilmiştir.
Araştırma sonuçlarına göre, ilköğretim öğrencilerinin özgürlük değerine ilişkin tutumları yüksek derecede olumlu olup; sınıf, başarı durumu, kardeş sayısı, kitap okuma alışkanlığı ve okulun bulunduğu muhitin sosyoekonomik düzeyi değişkenlerine göre anlamlı farklılık göstermektedir.