bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inluence of Different Levels of Cowdung on Mitigation of Water Deficit Effect on Wheat
Authors: Amin AKMR , Reza S 
Published: September 2021

The experiment was conducted in pot at the net house of the department of Agronomy, Sher-e-Bangla Agricultural University, Dhaka during the period from November, 2018 to March, 2019to find out the optimum dose(s) cowdung to mitigate the water deficit effect on wheat. The experiment comprised of two factors viz. factor A: Five levels of cowdung, i) C0= Control (No cowdung), C1= 25% less cowdung of recommended dose, C2 = Recommended dose of cowdung, C3 = 25% higher cowdung of recommended dose and C4 = 50% higher cowdung of recommended dose, and factor B: four levels of water deficit at, i) D0 = Control (No water deficit), D1= Crown root initiation stage (20-19 DAS), D2 = Booting stage (45-54 DAS) and D3= An thesis stage (55-64 DAS). The experiment was laid out in a Factorial R and omized Complete Block Design with three replications. The test crop variety was BARI Gom28. The result reveled that cowdung level had positive impact on yield of wheat under water deficit condition, and 50% higher cowdung of recommended dose (C4) gave the highest grain yield (5.12g plant-1). The particular treatment also produced the highest number of effective tillers plant-1 (5.25), spike length (10.39 cm), spikelet spike-1 (15.72), grains spike-1 (32.56), grains spikelet-1 (2.07) and 1000-grain weight (47.32 g) of wheat. The treatment C3 (25% higher cowdung of recommended dose) also gave statistically similar yield with C4 treatment. In respect of water deficit imposition treatments, grain yield was found the highest in control treatment which was statistically similar with water deficit imposition at booting stage treatment (D2). These two treatments also showed the higher and similar number of effective tillers plant-1 (4.86 and 4.58), spike length (10.53cm and 10.11cm), spikelets spike-1(15.50 and 15.19), grains spike-1 (34.10 and 30.17), grains spikelet-1 (2.20 and 1.98) and 1000-grain weight (45.42g and 45.36g, respectively). Regarding the interaction of levels of cowdung and water deficit imposition at different stages of plant growth, C4D0 and C3D0 were highest yielder which was attributed to higher 1000-seed weight, number of effective tillers plant-1, spikelets spike-1 and grains spike-1. Contrary, 25% higher cowdung than recommended dose (as it saved 25% cowdung) seems promising to overcome yield loss due to water deficit imposition at booting stage of wheat (D2). However, application of cowdung (12.5 t ha-1) was found effective to combat water deficit at booting stage (D2) of wheat compared to other growth stages.
Bangladesh Agron. J. 2021, 24(1): 93-100
KINERJA DINAS PEMBERDAYAAN MASYARAKAT DAN DESA DALAM MEWUJUDKAN PEMBERDAYAAN MASYARAKAT MELALUI PENGGUNAAN DANA DESA DI KABUPATEN BELU PROVINSI NUSA TENGGARA TIMUR
Authors: Taek Maximilianus Mario , Wasistiono Sadu , Meltarini Meltarini 
Published: September 2021

The use of Village Funds is not appropriate and there are still problems so that it has not reduced the poverty rate, this is because the guidance is not maximized by the Belu Regency PMD Office. This study aims to analyze performance of the Community and Village Empowerment Service in realizing community empowerment through the use of Village Funds. The theory used is the performance of Sinambela Lijan (2012), with indicators of productivity, responsiveness, responsibility and accountability. The approach to data analysis is the SWOT analysis with the Litmus test. This study used qualitative research method with descriptive approach, data collection techniques: interviews (17 informants) and documentation. The findings of the study indicate that human resource capacity is still low, infrastructure is still limited, lack of cross-sectoral coordination, lack of community understanding and weak institutional capacity in the village. Conclusion: The performance of the Community and Village Empowerment Service is quite good, but there are still some problems so that the authors convey several strategic issues, namely increasing the capacity of employees as trainers and facilitators so that community empowerment is more effective and maximizes the potential in the village so that it can be used to support community empowerment activities, with the aim of realizing Village independence.
Keywords: Performance, Village Funds, Community Empowerment
The Leadership Role in The Smart-Village Program in Banyuwangi District, East Java
Authors: Wargadinata Ella Lesmanawaty' 
Published: September 2021

The use of information communication technology (ICT) in government administration has changed the face of Weber's conventional bureaucracy into a modern model. The electronic or digital-based government model is an important milestone in this 21st century due to its ability to improve government performance, thereby increasing public satisfaction. The successful implementation of e-government is influenced by many beneficial and nonbeneficial determining factors, such as leadership. Therefore, this research aims to explore the leadership role of the Smart village program implemented in 2010 by the Banyuwangi District Government using a qualitative approach. Data were collected through observation in selected locations, interviews, and secondary sources. The data obtained were processed using the NVivo application process due to its ability to capture and build inductively concepts that describe research based on local perspectives. The results processed through the word cloud feature illustrate two interesting analyses. First Smart village is considered an online administration service by the Banyuwangi people because it is easy, fast, open, and full of certainty. Second leadership has 5 important roles, namely Charismatic, Innovative, Consistent, Cooperation, and Integrity. In conclusion, the success of e-government is strongly influenced by the usefulness of services for the community and the seriousness of the leadership to implement e-government not only as a political gimmick but to serve the community.

Keywords: Digital service, Transformational Leadership, Digital Society, Openness
A Novel Biosorbent From Hardwood Cellulose Nanofibrils Grafted With Poly(m-Aminobenzene Sulfonate) for Adsorption of Cr(VI)
Authors: Yu Yong Ho , An Liangliang , Bae Jin Ho , Heo Ji Won , Chen Jiansong , Jeong Hanseob , Kim Yong Sik 
Published: September 2021

Graphical AbstractBiosorbent from cellulose nanofibrils grafted with poly(m-aminobenzene sulfonate) (PABS) was prepared for effective detoxification and adsorption of Cr(VI) in an aqueous medium.
Circulating Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive Care
Authors: Hatanaka Kosaku , Ito Takashi , Madokoro Yutaro , Kamikokuryo Chinatsu , Niiyama Shuhei , Yamada Shingo , Maruyama Ikuro , Kakihana Yasuyuki 
Published: September 2021

Background: Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host responses to infection. Recent studies have suggested that endotheliopathy may be the common basis for multiple organ failure in sepsis. Under septic conditions, accumulation of proteases accelerates shedding of proteoglycans, such as syndecan-1, from the endothelial surface, resulting in augmented leukocyte adhesion to the vascular wall, enhanced vascular permeability, and intravascular coagulation. The purpose of this study was to determine the potential utility of syndecan-1 as a biomarker linking endotheliopathy to organ failure.Methods: One hundred patients with suspected infections who were admitted to the intensive care unit (ICU) at Kagoshima University Hospital were consecutively enrolled in the study. Serum syndecan-1 levels were measured using an in-house enzyme-linked immunosorbent assay. The difference between serum syndecan-1 levels in 28-day survivors and non-survivors was analyzed by the Mann–Whitney U-test. Receiver-operating characteristics curve analysis with area under the curve calculation was used to quantify the predictive performance of serum syndecan-1 for 28-day mortality. The correlations between serum syndecan-1 and coagulation markers were analyzed by Spearman's rank correlation test.Results: Serum syndecan-1 levels in non-survivors were significantly higher than those in survivors on Day 1 and Day 3 (P &lt; 0.01). Among multiple organ failures, coagulation failure and renal failure were significantly correlated with serum syndecan-1. Spearman's rank correlation test indicated that serum syndecan-1 was weakly but significantly correlated with disseminated intravascular coagulation score (rho = 0.33, P &lt; 0.01). Patients with serum syndecan-1 ≥21.4 ng/mL showed delayed recovery from thrombocytopenia relative to patients with serum syndecan-1 &lt;21.4 ng/mL.Conclusions: Elevated circulating syndecan-1 on the first day of ICU admission was associated with persistent thrombocytopenia and lethal outcome in patients with suspected sepsis.
Development and Validation of a Nomogram to Predict the 180-Day Readmission Risk for Chronic Heart Failure: A Multicenter Prospective Study
Authors: Gao Shanshan , Yin Gang , Xia Qing , Wu Guihai , Zhu Jinxiu , Lu Nan , Yan Jingyi , Tan Xuerui 
Published: September 2021

Background: The existing prediction models lack the generalized applicability for chronic heart failure (CHF) readmission. We aimed to develop and validate a widely applicable nomogram for the prediction of 180-day readmission to the patients.Methods: We prospectively enrolled 2,980 consecutive patients with CHF from two hospitals. A nomogram was created to predict 180-day readmission based on the selected variables. The patients were divided into three datasets for development, internal validation, and external validation (mean age: 74.2 ± 14.1, 73.8 ± 14.2, and 71.0 ± 11.7 years, respectively; sex: 50.2, 48.8, and 55.2% male, respectively). At baseline, 102 variables were submitted to the least absolute shrinkage and selection operator (Lasso) regression algorithm for variable selection. The selected variables were processed by the multivariable Cox proportional hazards regression modeling combined with univariate analysis and stepwise regression. The model was evaluated by the concordance index (C-index) and calibration plot. Finally, the nomogram was provided to visualize the results. The improvement in the regression model was calculated by the net reclassification index (NRI) (with tenfold cross-validation and 200 bootstraps).Results: Among the selected 2,980 patients, 1,696 (56.9%) were readmitted within 180 days, and 1,502 (50.4%) were men. A nomogram was established by the results of Lasso regression, univariate analysis, stepwise regression and multivariate Cox regression, as well as variables with clinical significance. The values of the C-index were 0.75 [95% confidence interval (CI): 0.72–0.79], 0.75 [95% CI: 0.69–0.81], and 0.73 [95% CI: 0.64–0.83] for the development, internal validation, and external validation datasets, respectively. Calibration plots were provided for both the internal and external validation sets. Five variables including history of acute heart failure, emergency department visit, age, blood urea nitrogen level, and beta blocker usage were considered in the final prediction model. When adding variables involving hospital discharge way, alcohol taken and left bundle branch block, the calculated values of NRI demonstrated no significant improvements.Conclusions: A nomogram for the prediction of 180-day readmission of patients with CHF was developed and validated based on five variables. The proposed methodology can improve the accurate prediction of patient readmission and have the wide applications for CHF.
Sulfur-Based Denitrification in Streambank Subsoils in a Headwater Catchment Underlain by Marine Sedimentary Rocks in Akita, Japan
Authors: Hayakawa Atsushi , Ota Hitoshi , Asano Ryoki , Murano Hirotatsu , Ishikawa Yuichi , Takahashi Tadashi 
Published: September 2021

Sulfur-based denitrification may be a key biogeochemical nitrate (NO3−) removal process in sulfide-rich regions, but it is still poorly understood in natural terrestrial ecosystems. We examined sulfur-driven NO3− reduction using streambank soils in a headwater catchment underlain by marine sedimentary rock in Akita, Japan. In a catchment exhibiting higher sulfide content in streambed sediment, we sampled two adjacent streambank soils of streambank I (two layers) and of streambank II (eight layers). Anaerobic long-term incubation experiments (40 days, using soils of streambank I) and short-term incubation experiments (5 days, using soils of streambank II) were conducted to evaluate variations of N solutes (NO3−, NO2−, and NH4+), N gases (NO, N2O), and the bacterial flora. In both experiments, two treatment solutions containing NO3− (N treatment), and NO3− and S2O32− (N + S treatment) were prepared. In the N + S treatment of the long-term experiment, NO3− concentrations gradually decreased by 98%, with increases in the SO42−, NO2−, NO, and N2O concentrations and with not increase in the NH4+, indicating denitrification had occurred with a high probability. Temporal accumulation of NO2− was observed in the N + S treatment. The stoichiometric ratio of SO42− production and NO3− depletion rates indicated that denitrification using reduced sulfur occurred even without additional S, indicating inherent S also served as an electron donor for denitrification. In the short-term incubation experiment, S addition was significantly decreased NO3− concentrations and increased NO2−, NO, and N2O concentrations, especially in some subsoils with higher sulfide contents. Many denitrifying sulfur-oxidizing bacteria (Thiobacillus denitrificans and Sulfuricella denitrificans) were detected in both streambank I and II, which dominated up to 5% of the entire microbial population, suggesting that these bacteria are widespread in sulfide-rich soil layers in the catchment. We concluded that the catchment with abundant sulfides in the subsoil possessed the potential for sulfur-driven NO3− reduction, which could widely influence N cycling in and NO3− export from the headwater catchment.
Alpha-1 Antitrypsin Z Variant (AAT PI*Z) as a Risk Factor for Intrahepatic Cholestasis of Pregnancy
Authors: Kosinski Przemyslaw , Kedzia Malgorzata , Mostowska Adrianna , Gutaj Pawel , Lipa Michal , Wender-Ozegowska Ewa , Rozy Adriana , Chorostowska-Wynimko Joanna , Wielgos Miroslaw , Jezela-Stanek Aleksandra 
Published: September 2021

Background: Intrahepatic cholestasis of pregnancy (ICP; prevalence 0.2–15.6%) is the most common pregnancy-related liver disorder. It may have serious consequences for a pregnancy, including increased risk of preterm delivery, meconium staining of amniotic fluid, fetal bradycardia, distress, and fetal demise. In cases of high bile acids (&gt;100μmol/L), patients have 10-fold increase in the risk of stillbirth. Biophysical methods of fetal monitoring, such as cardiotocography, ultrasonography, or Doppler have been proven unreliable for risk prediction in the course of intrahepatic cholestasis. Therefore, we believe extensive research for more specific, especially early, markers should be carried out. By analogy with cholestasis in children with inherited alpha-1 antitrypsin deficiency (AATD), we hypothesized the SERPINA1 Z pathogenic variant might be related to a higher risk of cholestasis in pregnancy. This study aimed to investigate the most common AATD variants (Z and S SERPINA1 alleles) in a group of cholestatic pregnant women.Results: The Z carrier frequency was calculated to be 6.8%, which is much higher compared to the general population [2.3%; the Chi-squared test with Yates correction is 6.8774 (p=0.008)].Conclusion: Increased prevalence of SERPINA1 PI*Z variant in a group of women with intrahepatic cholestasis may suggest a possible genetic origin of a higher risk of intrahepatic cholestasis in pregnancy.
Choriocapillaris Ischemia at the Leakage Point of Patients With Acute Central Serous Chorioretinopathy
Authors: Wang Zuofen , Xin Zhaoting , Yang Jun , Lu Huawen , Wang Haiying , Zhu Lin 
Published: September 2021

Purpose: We aimed to determine ischemia of the choriocapillaris at the leakage point of patients with acute central serous chorioretinopathy (CSC) by optical coherence tomographic angiography (OCTA).Methods: A retrospective study of 38 eyes of 38 acute CSC patients with spontaneous complete resolution of subretinal fluid (SRF) was conducted and patients were followed for 3 months. Fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) were performed at baseline. Best corrected visual acuity (BCVA) and OCTA were collected at baseline and at follow-up visits. An age- and refractive error-matched control group consisted of 40 eyes of 40 healthy people.Results: The BCVA of patients significantly improved at 1 and 3 months. At baseline, all eyes showed a decreased choriocapillaris vessel density. The mean vessel density of superficial choroid (VDSC) at the leakage point area was 44.18 ± 9.27, which increased to 54.31 ± 9.70 at 1 month (p &lt; 0.001) and to 55.19 ± 6.46 at 3 months (p &lt; 0.001). The mean vessel density ratio was 0.90 ± 0.16 at baseline, which increased to 0.96 ± 0.15 at 1 month (p = 0.037) and to 0.97 ± 0.08 at 3 months (p = 0.016). The highest VDSC of patients was lower than that of normal control (p &lt; 0.001).Conclusions: The VDSC at the leakage point of acute CSC patients was significantly thinner and regularly increased with the recovery process, which suggested that ischemia might be one of the initiating factors in the pathogenesis of acute CSC.
Comparative Genomic Analysis Uncovered Evolution of Pathogenicity Factors, Horizontal Gene Transfer Events, and Heavy Metal Resistance Traits in Citrus Canker Bacterium Xanthomonas citri subsp. citri
Authors: Huang Chien-Jui , Wu Ting-Li , Zheng Po-Xing , Ou Jheng-Yang , Ni Hui-Fang , Lin Yao-Cheng 
Published: September 2021

Background: Worldwide citrus production is severely threatened by Asiatic citrus canker which is caused by the proteobacterium Xanthomonas citri subsp. citri. Foliar sprays of copper-based bactericides are frequently used to control plant bacterial diseases. Despite the sequencing of many X. citri strains, the genome diversity and distribution of genes responsible for metal resistance in X. citri subsp. citri strains from orchards with different management practices in Taiwan are not well understood.Results: The genomes of three X. citri subsp. citri strains including one copper-resistant strain collected from farms with different management regimes in Taiwan were sequenced by Illumina and Nanopore sequencing and assembled into complete circular chromosomes and plasmids. CRISPR spoligotyping and phylogenomic analysis indicated that the three strains were located in the same phylogenetic lineages and shared ∼3,000 core-genes with published X. citri subsp. citri strains. These strains differed mainly in the CRISPR repeats and pathogenicity-related plasmid-borne transcription activator-like effector (TALE)-encoding pthA genes. The copper-resistant strain has a unique, large copper resistance plasmid due to an unusual ∼40 kbp inverted repeat. Each repeat contains a complete set of the gene cluster responsible for copper and heavy metal resistance. Conversely, the copper sensitive strains carry no metal resistance genes in the plasmid. Through comparative analysis, the origin and evolution of the metal resistance clusters was resolved.Conclusion: Chromosomes remained constant among three strains collected in Taiwan, but plasmids likely played an important role in maintaining pathogenicity and developing bacterial fitness in the field. The evolution of pathogenicity factors and horizontal gene transfer events were observed in the three strains. These data suggest that agricultural management practices could be a potential trigger for the evolution of citrus canker pathogens. The decrease in the number of CRISPR repeats and pthA genes might be the result of adaptation to a less stressful environment. The metal resistance genes in the copper resistant X. citri strain likely originated from the Mauritian strain not the local copper-resistant X. euvesicatoria strain. This study highlights the importance of plasmids as ‘vehicles’ for exchanging genetic elements between plant pathogenic bacteria and contributing to bacterial adaptation to the environment.
Plasma p-tau181 Level Predicts Neurodegeneration and Progression to Alzheimer's Dementia: A Longitudinal Study
Authors: Wang Yan-Li , Chen Jinglong , Du Zhong-Li , Weng Haoyi , Zhang Yuan , Li Runzhi , Jia Ziyan , Sun Mengfan , Jiang Jiwei , Wang Fang-Ze , Xu Jun ,   Alzheimer's Disease Neuroimaging Initiative
Published: September 2021

Background: Plasma-based biomarkers would be potential biomarkers for early diagnosis of Alzheimer's disease (AD) because they are more available and cost-effective than cerebrospinal fluid (CSF) or neuroimaging. Therefore, we aimed to evaluate whether phosphorylated tau181 (p-tau181) in plasma could be an accurate AD predictor.Methods: Participants from the ADNI database included 185 cognitively unimpaired subjects with negative Aβ (CU–), 66 subjects with pre-clinical AD (CU with positive Aβ), 164 subjects with mild cognitive impairment with negative Aβ (MCI–), 254 subjects with prodromal AD (MCI with positive Aβ), and 98 subjects with dementia. Multiple linear regression models, linear mixed-effects models, and local regression were used to explore cross-sectional and longitudinal associations of plasma p-tau181 with cognition, neuroimaging, or CSF biomarkers adjusted for age, sex, education, and APOE genotype. Besides, Kaplan–Meier and adjusted Cox-regression model were performed to predict the risk of progression to dementia. Receiver operating characteristic analyses were performed to evaluate the predictive value of p-tau181.Results: Plasma p-tau181 level was highest in AD dementia, followed by prodromal AD and pre-clinical AD. In pre-clinical AD, plasma p-tau181 was negatively associated with hippocampal volume (β = −0.031, p-value = 0.017). In prodromal AD, plasma p-tau181 was associated with decreased global cognition, executive function, memory, language, and visuospatial functioning (β range −0.119 to −0.273, p-value &lt; 0.05) and correlated with hippocampal volume (β = −0.028, p-value &lt; 0.005) and white matter hyperintensity volume (WMH) volume (β = 0.02, p-value = 0.01). In AD dementia, increased plasma p-tau181 was associated with worse memory. In the whole group, baseline plasma p-tau181 was significantly associated with longitudinal increases in multiple neuropsychological test z-scores and correlated with AD-related CSF biomarkers and hippocampal volume (p-value &lt; 0.05). Meanwhile, CU or MCI with high plasma p-tau181 carried a higher risk of progression to dementia. The area under the curve (AUC) of the adjusted model (age, sex, education, APOE genotype, and plasma p-tau181) was 0.78; that of additionally included CSF biomarkers was 0.84.Conclusions: Plasma p-tau181 level is related to multiple AD-associated cognitive domains and AD-related CSF biomarkers at the clinical stages of AD. Moreover, plasma p-tau181 level is related to the change rates of cognitive decline and hippocampal atrophy. Thus, this study confirms the utility of plasma p-tau181 as a non-invasive biomarker for early detection and prediction of AD.