bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring new physics contributions to CP violation in $$\tau ^- \rightarrow K^-\pi ^0\nu _{\tau } $$
Authors: Delepine David , Faisel Gaber , Ramirez Carlos A. 
Published: April 2021

AbstractA general analysis of possible violation of CP in processes like$$\tau \rightarrow K\pi \nu $$τ→Kπν, for unpolarized$$\tau $$τis presented. In this paper, we derive the new contributions to the effective Hamiltonian governs$$\vert \Delta S \vert =1$$|ΔS|=1semileptonic tau decays in the framework of two Higgs doublet model with generic Yukawa structure and Leptoquarks models. Within these models, we list all operators, in the effective Hamiltonian and provide analytical expression for their corresponding Wilson coefficients. Moreover, we analyze the role of the different contributions, originating from the scalar, vecor and tensor hadronic currents, in generating direct CP asymmetry in the decay rate of$$\tau ^-\rightarrow K^-\pi ^0\nu _\tau $$τ-→K-π0ντ. We show that non vanishing direct CP asymmetry in the decay rate of$$\tau ^-\rightarrow K^-\pi ^0\nu _\tau $$τ-→K-π0ντcan be generated due to the presence of both, the weak phase in the Wilson coefficient corresponding to the tensor operator and the strong phase difference resulting from the interference between the form factors expressing the matrix elements of the vector and tensor hadronic currents. After taking into account all relevant constraints, we find that the generated direct CP asymmetry is of order$$10^{-8}$$10-8which is several orders of magnitude larger than the standard model prediction. We show also that, in two Higgs doublet model with generic Yukawa structure , direct local or non integrated CP violation can be as large as 0.3 % not far from experimental possibilities. This kind of asymmetry can be generated due to the interference between vector and scalar contributions with different weak phases which is not the case in the SM.
Bibliometric Analysis of the English Musculoskeletal Literature over the Last 30 Years
Authors: Loder Randall T. , Kacena Melissa A. , Ogbemudia Blessing , Ngwe Hervé Nonga , Aasar Abdul , Ninad Nehal , Mufti Osama , Gunderson Zachary , Whipple Elizabeth C. 
Published: April 2021

Publication and authorship are important in academia for career advancement, obtaining grants, and improved patient care. There has been a recent interest in bibliometric changes over time, especially regarding the gender gap. The purpose of this study was to explore bibliometric changes in the musculoskeletal literature. Bibliometric variables (number of authors, institutions, countries, pages, references, corresponding author position, author gender, geographic region of origin, and editorial board makeup) were analyzed for 5 basic science and 12 clinically oriented musculoskeletal journals from 1985 through 2016. Statistical analyses comprised bivariate analyses, multifactorial ANOVAs, and logistic regression analyses. A

p

< 0.005 was considered significant. Nearly, all variables increased over time. Asia had the highest number of authors and corresponding author positions, Australia/New Zealand the highest number of institutions and references, North America the highest number of pages, and Europe the highest number of countries. Those with a female first author had more authors, institutions, countries, references, and pages. Likewise, those with a female corresponding author had more authors, institutions, countries, references, and pages. Single-authored manuscripts decreased over time. The percentage of female first authors rose from 10.8% in 1985–1987 to 23.7% in 2015–2016. There were more female 1st authors in the basic science journals compared to the clinical journals (33.2% vs. 12.7%). Single-authored manuscripts were more likely to be written by males (5.1 vs. 2.4%) and decreased over time. The many differences by geographic region of origin likely reflect different socio/cultural attitudes regarding academia and research, as well as the gender composition of the disciplines by geographic region. Overall, there has been an increase in the number of female 1st and corresponding authors, editorial board members, and chief editors, indicating a slow but progressive narrowing of the gender gap.
EGFR Activates a TAZ-Driven Oncogenic Program in Glioblastoma
Authors: Gao Minling , Fu Yi , Zhou Weiqiang , Gui Gege , Lal Bachuchu , Li Yunqing , Xia Shuli , Ji Hongkai , Eberhart Charles G. , Laterra John , Ying Mingyao 
Published: April 2021

Abstract

Hyperactivated EGFR signaling is a driver of various human cancers, including glioblastoma (GBM). Effective EGFR-targeted therapies rely on knowledge of key signaling hubs that transfer and amplify EGFR signaling. Here we focus on the transcription factor TAZ, a potential signaling hub in the EGFR signaling network. TAZ expression was positively associated with EGFR expression in clinical GBM specimens. In patient-derived GBM neurospheres, EGF induced TAZ through EGFR–ERK and EGFR–STAT3 signaling, and the constitutively active EGFRvIII mutation caused EGF-independent hyperactivation of TAZ. Genome-wide analysis showed that the EGFR–TAZ axis activates multiple oncogenic signaling mechanisms, including an EGFR–TAZ–RTK positive feedback loop, as well as upregulating HIF1α and other oncogenic genes. TAZ hyperactivation in GBM stem-like cells induced exogenous mitogen-independent growth and promoted GBM invasion, radioresistance, and tumorigenicity. Screening a panel of brain-penetrating EGFR inhibitors identified osimertinib as the most potent inhibitor of the EGFR–TAZ signaling axis. Systemic osimertinib treatment inhibited the EGFR–TAZ axis and in vivo growth of GBM stem-like cell xenografts. Overall these results show that the therapeutic efficacy of osimertinib relies on effective TAZ inhibition, thus identifying TAZ as a potential biomarker of osimertinib sensitivity.

Significance:
This study establishes a genome-wide map of EGFR–TAZ signaling in glioblastoma and finds osimertinib effectively inhibits this signaling, justifying its future clinical evaluation to treat glioblastoma and other cancers with EGFR/TAZ hyperactivation.
Circulating Small Extracellular Vesicles Activate TYRO3 to Drive Cancer Metastasis and Chemoresistance
Authors: Park Miso , Kim Ji Won , Kim Kyu Min , Kang Seungmin , Kim Wankyu , Kim Jin-Ki , Cho Youngnam , Lee Hyungjae , Baek Moon Chang , Bae Ju-Hyun , Lee Seung Hyun , Jeong Sung Baek , Lim Sung Chul , Jun Dae Won , Cho Sung Yun , Kim Yeonji , Choi Yong June , Kang Keon Wook 
Published: April 2021

Abstract

Extracellular vesicles (EV) in the tumor microenvironment have emerged as crucial mediators that promote proliferation, metastasis, and chemoresistance. However, the role of circulating small EVs (csEV) in cancer progression remains poorly understood. In this study, we report that csEV facilitate cancer progression and determine its molecular mechanism. csEVs strongly promoted the migration of cancer cells via interaction with phosphatidylserine of csEVs. Among the three TAM receptors, TYRO3, AXL, and MerTK, TYRO3 mainly interacted with csEVs. csEV-mediated TYRO3 activation promoted migration and metastasis via the epithelial–mesenchymal transition and stimulation of RhoA in invasive cancer cells. Additionally, csEV–TYRO3 interaction induced YAP activation, which led to increased cell proliferation and chemoresistance. Combination treatment with gefitinib and KRCT-6j, a selective TYRO3 inhibitor, significantly reduced tumor volume in xenografts implanted with gefitinib-resistant non–small cell lung cancer cells. The results of this study show that TYRO3 activation by csEVs facilitates cancer cell migration and chemoresistance by activation of RhoA or YAP, indicating that the csEV/TYRO3 interaction may serve as a potential therapeutic target for aggressive cancers in the clinic.

Significance:
These findings demonstrate that circulating extracellular vesicles are a novel driver in migration and survival of aggressive cancer cells via TYRO3 activation.
Parameter Space Factorization for Zero-Shot Learning across Tasks and Languages
Authors: Ponti Edoardo M. , Vulić Ivan , Cotterell Ryan , Parovic Marinela , Reichart Roi , Korhonen Anna 
Published: April 2021

AbstractMost combinations of NLP tasks and language varieties lack in-domain examples for supervised training because of the paucity of annotated data. How can neural models make sample-efficient generalizations from task–language combinations with available data to low-resource ones? In this work, we propose a Bayesian generative model for the space of neural parameters. We assume that this space can be factorized into latent variables for each language and each task. We infer the posteriors over such latent variables based on data from seen task–language combinations through variational inference. This enables zero-shot classification on unseen combinations at prediction time. For instance, given training data for named entity recognition (NER) in Vietnamese and for part-of-speech (POS) tagging in Wolof, our model can perform accurate predictions for NER in Wolof. In particular, we experiment with a typologically diverse sample of 33 languages from 4 continents and 11 families, and show that our model yields comparable or better results than state-of-the-art, zero-shot cross-lingual transfer methods. Our code is available at github.com/cambridgeltl/parameter-factorization.
Does a bacterial infection lead to a nutritional deficiency in foraging Allenby's gerbils?
Authors: Makin Douglas Ferguson , Kotler Burt P. , Sargunaraj Franklin 
Published: April 2021

Abstract
Bacterial infections can have both direct (physiological) and indirect (ecological) costs for their hosts. The direct costs of infection may include nutritional deficiencies, which reduce body condition over time, and result in the hosts modifying their foraging behaviour to compensate for any losses. Allenby’s gerbils are commonly infected with the Mycoplasma haemomuris-like bacteria, which may induce choline (essential vitamin) and arginine (amino acid) deficiencies. Gerbils should therefore alter their behaviour to make up for any shortfalls in nutrient production and retention. We tested two predictions. 1) infected gerbils would compensate for nutrient losses by spending more time foraging in patches, including, during riskier periods of owl presence, and in riskier open microhabitats. Furthermore, infected gerbils would preferentially forage from patches supplemented with choline and arginine enriched food over control food. 2) Alternatively, if infection did not create a nutrient deficiency, then infected individuals would display a similar pattern of patch use to uninfected individuals, and harvest similar amounts of food from supplemented and control patches. Our findings supported the second prediction. There was no observed difference in foraging behaviour between infected and uninfected individuals. Moreover, infected gerbils did not selectively forage more intensively from food patches enriched with either choline or arginine seed over the control patches. These results suggest that this bacteria-gerbil interaction does not result in a nutrient deficiency as observed for other Mycoplasma-rodent systems.
Energy Flux into Near-Inertial Internal Waves Below the Surface Boundary Layer in the Global Ocean
Authors: Sun Bingrong , Wang Shengpeng , Yuan Man , Wang Hong , Jing Zhao , Chen Zhaohui , Wu Lixin 
Published: April 2021

AbstractNear-inertial internal waves (NIWs) are thought to play an important role in powering the turbulent diapycnal mixing in the ocean interior. Nevertheless, the energy flux into NIWs below the surface boundary layer (SBL) in the global ocean is still poorly understood. This key problem is addressed in this study based on a Community Earth System Model (CESM) simulation with a horizontal resolution of ~0.1° for its oceanic component and ~0.25° for its atmospheric component.The CESM shows good skill in simulating NIWs globally, reproducing the observed magnitude and spatial pattern of surface NIW currents and wind power on NIWs (WI). The simulated downward flux of NIW energy (FSBL) at the SBL base is positive everywhere. Its quasi-global integral (excluding the region within 5°S-5°N) is 0.13 TW, about one-third the value of WI. The ratio of local FSBL to WI varies substantially over the space. It exhibits an increasing trend with the enstrophy of balanced motions (BMs) and a decreasing trend with WI.The kinetic energy transfer from model-resolved BMs to NIWs is positive from the SBL base to 600 m but becomes negative further downwards. The quasi-global integral of energy transfer below the SBL base is two orders of magnitude smaller than that of FSBL, suggesting the resolved BMs in the CESM simulations making negligible contributions to power NIWs in the ocean interior.
Cardiovascular Disease Risk Factors Among Immigrant and US-Born Adults in New York City
Authors: Chernov Claudia , Wang Lisa , Thorpe Lorna E. , Islam Nadia , Freeman Amy , Trinh-Shevrin Chau , Kanchi Rania , Perlman Sharon E. 
Published: April 2021

Objectives Immigrant adults tend to have better health than native-born adults despite lower incomes, but the health advantage decreases with length of residence. To determine whether immigrant adults have a health advantage over US-born adults in New York City, we compared cardiovascular disease (CVD) risk factors among both groups. Methods Using data from the New York City Health and Nutrition Examination Survey 2013-2014, we assessed health insurance coverage, health behaviors, and health conditions, comparing adults ages ≥20 born in the 50 states or the District of Columbia (US-born) with adults born in a US territory or outside the United States (immigrants, following the National Health and Nutrition Examination Survey) and comparing US-born adults with (1) adults who immigrated recently (≤10 years) and (2) adults who immigrated earlier (>10 years). Results For immigrant adults, the mean time since arrival in the United States was 21.8 years. Immigrant adults were significantly more likely than US-born adults to lack health insurance (22% vs 12%), report fair or poor health (26% vs 17%), have hypertension (30% vs 23%), and have diabetes (20% vs 11%) but significantly less likely to smoke (18% vs 27%) (all P < .05). Comparable proportions of immigrant adults and US-born adults were overweight or obese (67% vs 63%) and reported CVD (both 7%). Immigrant adults who arrived recently were less likely than immigrant adults who arrived earlier to have diabetes or high cholesterol but did not differ overall from US-born adults. Conclusions Our findings may help guide prevention programs and policy efforts to ensure that immigrant adults remain healthy.
Accuracy of Medical Examiner’s Assessment for Near–Real-Time Surveillance of Fatal Drug Overdoses, King County, Washington, March 2017–February 2018
Authors: Vannice Kirsten , Hood Julia , Yarid Nicole , Kay Meagan , Harruff Richard , Duchin Jeff 
Published: April 2021

Objectives Up-to-date information on the occurrence of drug overdose is critical to guide public health response. The objective of our study was to evaluate a near–real-time fatal drug overdose surveillance system to improve timeliness of drug overdose monitoring. Methods We analyzed data on deaths in the King County (Washington) Medical Examiner’s Office (KCMEO) jurisdiction that occurred during March 1, 2017–February 28, 2018, and that had routine toxicology test results. Medical examiners (MEs) classified probable drug overdoses on the basis of information obtained through the death investigation and autopsy. We calculated sensitivity, positive predictive value, specificity, and negative predictive value of MEs’ classification by using the final death certificate as the gold standard. Results KCMEO investigated 2480 deaths; 1389 underwent routine toxicology testing, and 361 were toxicologically confirmed drug overdoses from opioid, stimulant, or euphoric drugs. Sensitivity of the probable overdose classification was 83%, positive predictive value was 89%, specificity was 96%, and negative predictive value was 94%. Probable overdoses were classified a median of 1 day after the event, whereas the final death certificate confirming an overdose was received by KCMEO an average of 63 days after the event. Conclusions King County MEs’ probable overdose classification provides a near–real-time indicator of fatal drug overdoses, which can guide rapid local public health responses to the drug overdose epidemic.
Why allied health professionals use evidence-based clinical guidelines in stroke rehabilitation: A systematic review and meta-synthesis of qualitative studies
Authors: Halls Dayna , Murray Carolyn , Sellar Ben 
Published: April 2021

Objective: To capture qualitative research about the perspectives and reasoning of allied health professionals about variability in the use of clinical guidelines in stroke rehabilitation. Data sources: Ovid Medline, Psychinfo, Cochrane, Ovid Emcare, Scopus and Web of Science. Method: The review protocol followed the Enhancing Transparency in Reporting the Synthesis of Qualitative Research (ENTREQ) statement. Qualitative or mixed methods research that provided qualitative data about use of clinical guidelines delivered by allied health professionals in stroke rehabilitation was included. Clinical guidelines included any evidence-based documents that guided allied health stroke rehabilitation practice. All studies were screened in duplicate at title and abstract and then at full text. Included studies were appraised using the McMaster Critical Appraisal Tool. Results: Data from 850 allied health professionals in 22 qualitative research studies from seven different countries were analysed and synthesised. Four themes were developed including: context necessitates strategy, all clients are different, systemic changes are needed and need a good reason to change something. The findings aligned with the four arms of evidence-base practice. Allied health professionals use clinical guidelines when they align with their reasoning and match the ‘sweet spot’ for client goals and circumstance. Clinical guideline use is attributed to sufficient resourcing, time and motivation and a strong research culture within health systems. Conclusions: Variabilities in clinical guideline use by allied health professionals are due to their clinical reasoning, contextual factors, client characteristics and enabling health systems.
Passive flow control of shock-induced dynamic stall via surface-based trapped vortex generators
Authors: Al-Jaburi Khider , Feszty Daniel 
Published: April 2021

A novel passive approach for controlling the flow in a 2D dynamic stall at variabl freestream is investigated. 2D computational fluid dynamics simulations of an SC1095 airfoil with surface-based trapped vortex generator (STVG) type passive flow control were conducted. The airfoil was exposed to a fluctuating freestream of Mach 0.537 ± 0.205 and Re = 6.1 × 106 (based on the mean Mach number) and experienced a 10° ± 10° pitch oscillation with a frequency of 4.25 Hz. These conditions were selected as an approximation to the flow experienced by a UH-60A helicopter rotor airfoil section in an actual fast forward flight test case. The baseline simulations were cautiously validated with experimental data for both transonic flow and dynamic stall under the variable freestream. Then, 20 different local STVGs type geometry modifications were investigated as a means of passive flow control. Modifications were examined on both the airfoil’s upper and lower surfaces. Results showed that the STVGs were able to mitigate the negative effects of shock-induced dynamic stall. The best geometries could reduce the peak negative pitching moment by as much as 9–23% during the transonic phase of a cycle and by as much as 19–71% during the dynamic stall phase. Also, they were able to reduce peak drag by 8–20% in the transonic phase and by 15–44% in the dynamic stall phase. On the other hand, the lift-to-drag ratio was significantly increased by 3–28% per one rotor cycle. All the above advantages came at virtually no penalty in the lift.
Concomitant intramedullary nailing and plate augmentation as a single-stage procedure in treating complicated nonunited femoral shaft fractures
Authors: Khalifa Ahmed A , Fadle Amr A , Elsherif Mohamed E , Said Hatem G , Elsherif Essam , Said Galal , Refai Omar 
Published: April 2021

Background and Purpose: Complicated femur fracture represents a major challenge for the orthopedic surgeon, with failed internal fixation, nonunion with broken intramedullary nail (IMN), and infected nonunion among the complications. Mechanical instability, as well as the poor biological environment, is considered as a concern when treating these cases. The purpose of this study was to evaluate concomitant IMN and plate augmentation as a single-stage procedure for the management of multiply operated nonunited femoral shaft fractures. Materials and Methods: Between January 2015 and May 2018, nine patients (eight men) with an average age of 40.8 years (range 25–70) diagnosed as nonunion femoral fractures after an average of four previous surgeries (range 2–6). All patients were available for follow-up with an average of 22 months (range 12–36). Results: The average time for fracture union was 6.7 months (range 3–12); five patients needed bone grafting to compensate for the bone defect encountered during the initial procedure, and two patients required secondary bone grafting after 6 months follow-up. Two patients presented with surgical site infection which was treated by antibiotics and daily dressing. The average leg length discrepancy at last follow-up was 1 cm (range 0.5–1.5). No patient had a metalwork failure or needed removal of the implants. Conclusion: In treating complicated multiply operated nonunited femoral shaft fractures, we believe that this technique can provide a robust mechanical foundation as well as an improved biological environment for such nonunited fractures to heal.
Interprofessional dynamics that promote client empowerment in mental health practice: A social work perspective
Authors: Cui Jialiang , Newman Christy E , Lancaster Kari , Mao Limin 
Published: April 2021

Summary Interprofessional practice has been broadly endorsed as a strategy which supports the delivery of high-quality health services. Few studies have addressed the dynamics inherent to interprofessional mental health practice in an era in which client empowerment is prioritised and valued. Social work perspectives are also underexplored in the studies which have been published on interprofessional health care, despite the increasingly important role of this discipline in community mental health contexts. Through a thematic analysis of 26 semi-structured interviews, this study explored the perspectives of mental health social workers located in two geographically and culturally distinctive sites (Hong Kong and Sydney), and identified a strong theme encompassing their concerns about the facilitation of client empowerment in interprofessional settings. Findings Participant accounts direct attention to the strategies required to co-constitute the shared territories of the different mental health professions. Findings also highlight the frustration with recent mental health reforms which aim to challenge power differentials in interprofessional decision-making. Strategies were proposed for supporting the construction of shared language among different professions, revealing the creativity and insight of practitioners in managing the conflicts arising from interactions between different professional knowledge systems. The comparison of Hong Kong and Sydney accounts highlights the importance of structural, political and cultural influences in supporting not only interprofessional collaboration but also the independence and effectiveness of distinct professional roles. Application This article provides unique insights which aim to strengthen the contribution of social work to interprofessional practice in the promotion of empowerment-oriented interprofessional practice and education.