bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association Between Lipid Ratio and Depression: A Cross-Sectional Study
Authors: Han A Lum 
Published: October 2021

Abstract
Background: Depression is associated with the total cholesterol, low-density cholesterol, triglycerides, and high-density cholesterol levels in the blood. However, there are only a few studies on the relationship between depression and lipid ratios. Therefore, the aim of this study was to investigate the correlation between depression and different lipid ratios.Methods: This study was conducted using data from the Korea National Health and Nutrition Examination Survey. A total of 11,648 adult men and women aged 19 years and older, without missing data, were included in this study. Depression was diagnosed using the Patient Health Questionnaire-9. The associations between depression and total cholesterol/high-density lipoprotein cholesterol, low-density cholesterol/high-density lipoprotein cholesterol, and triglyceride/high-density lipoprotein cholesterol ratio were analyzed. A complex sample logistic regression test was used for the analysis of the odds ratios of depression.Results: In males, the total cholesterol/high-density lipoprotein cholesterol and low-density cholesterol/high-density lipoprotein cholesterol ratios were not associated with depression. In addition, an increase in triglyceride/high-density lipoprotein cholesterol ratio by 1 was associated with a 1.041-fold higher probability of depression in males. In females, the three lipid ratios were not associated with depression.Conclusions: Triglyceride/high-density lipoprotein cholesterol ratio is associated with depression in males. Further studies are necessary to cross-validate, explore the biological mechanism, and identify the clinical implication of this correlation.
PH Controlled the Supramolecular Assemblies of Two Guanosine Monophosphate Cadmium Metal Coordination Complexes: Structure and Chirality
Authors: Iqbal Muhammad Javed , Li Zhongkui , Khan Maroof Ahmad , Hussain Wajid , Riaz Muhammad Sohail , Shoukat Rizwan , Talha Khalid , li hui 
Published: October 2021

Abstract
In biological systems Chirality is important property from small molecules to macromolecules. The construction of homochiral coordination supramolecules in crystal and helical delivers the connection of molecular and macromolecular chirality. Complexity and properties in the presence of cadmium ion and bpe auxiliary ligand for bio-molecular guanosine-5- monophosphate disodium salt (GMP) was studied. The two Complexes 1 and 2 have been investigated the impact of auxiliary ligand bpe, hydroxy group on the sugar motif and pH for coordination of GMP ligands. The interaction of mixed ligands for growth and advancement of chiral complexes was controlled by the alteration of pH values for coordination of guanosine-5-monophosphate nucleotide with cadmium Cd (II) metal. The chirality of complexes 1 and 2 was studied with solid circular dichroism (CD) spectroscopy, including supramolecular chirality and extended auxiliary ligand (EAC) combining with the crystal structure analysis. The various hydrogen bonding and auxiliary ligand are the special means of transporting chirality from isolated molecules to dynamic supramolecular three-dimensional designs of GMP nucleotide crystals. The research results will be benefit to the controlling supramolecular assembly with well-defined structure and properties.
Genomic Comparisons of Two Armillaria Species with Different Ecological Behaviors and Their Associated Soil Microbial Communities
Authors: Caballero Jorge Ibarra , Lalande Bradley M , Hanna John W , Klopfenstein Ned B , Kim Mee-Sook , Stewart Jane E 
Published: October 2021

Abstract
Armillaria species show considerable variation in ecological roles and virulence, from mycorrhizae and saprophytes to important root pathogens of trees and horticultural crops. We studied two Armillaria species that can be found in coniferous forests of northwestern USA and southwestern Canada. Armillaria altimontana is considered as a weak, opportunistic pathogen of coniferous trees, but it also appears to exhibit in situ biological control against A. solidipes, formerly North American A. ostoyae, which is considered a virulent pathogen of coniferous trees. Here, we describe their genome assemblies and present a functional annotation of the predicted genes and proteins for the two Armillaria species that exhibit contrasting ecological roles. In addition, the soil microbial communities were examined in association with the two Armillaria species within a 45-year-old plantation of western white pine (Pinus monticola) in northern Idaho, USA, where A. altimontana was associated with improved tree growth and survival, while A. solidipes was associated with reduced growth and survival.
Curcumin Alleviates LPS-Induced Inflammation and Apoptosis in Vascular Smooth Muscle Cells Via Inhibition of the NF- κ B and JNK Signaling Pathways
Authors: Ruan Haohang , Huang Qing , Wan Benting , Yang Ming 
Published: October 2021

Abstract
Background: Curcumin plays an important role in inflammation. This study was aimed to investigate the effect of curcumin on vascular smooth muscle cells (VSMCs) injury induced by lipopolysaccharide (LPS) and its mechanism. Methods: VSMCs cells were treated with different concentrations of curcumin (0, 50, 100 and 150 μ g / mL). CCK-8 assay and flow cytometry were used to monitor the effects of curcumin on LPS-induced cell viability and apoptosis. The expression and release of inflammatory cytokines in VSMCs cells were detected by real-time quantitative polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA). The proteins expressions of NF- κB and JNK signaling pathways were analyzed by western blot. Results: Curcumin could reduce LPS induced inflammatory injury by increasing VSMC's cell viability, reducing apoptosis and inhibiting the release of inflammatory cytokines. In addition, curcumin increased the expression of Toll-like receptor 4 (TLR4) in LPS treated VSMCs. In terms of mechanism, we found that curcumin attenuated LPS-induced cell injury in VSMCs via inhibition of NF- κ B and the JNK signal pathway. Conclusion: Curcumin can protect VSMCs from LPS induced inflammatory injury, which may be related to the blocking of NF- κ B and the JNK signaling pathway. Curcumin may be a potential drug for the treatment of atherosclerosis.
Molecular investigation of the virucidal activity of proanthocyanidin from Alpinia zerumbet against the influenza A virus
Authors: Morimoto Hayato , Hatanaka Tadashi , Narusaka Mari , Narusaka Yoshihiro 
Published: October 2021

Abstract
Proanthocyanidins (PACs) have various bioactivities, such as being anti-bacterial, anti-cancer, and anti-oxidant. Consequently, they have been vigorously studied for the development of new natural bioactive compounds. Recently, AzPAC was isolated from the medicinal plant Alpinia zerumbet, and it was found to inhibit the infection of animal viruses, influenza A viruses (IAVs), and porcine epidemic diarrhea virus. The virucidal activity of AzPAC means that it can interact directly with viral particles. However, few studies have investigated the preventive mechanism utilized by AzPAC on influenza virus replication. In this study, the composition of AzPAC and the affinity between AzPAC and IAVs was investigated in detail. We found that AzPAC was composed of an epicatechin monomer, which was linked by inter-flavan bonds between the C4 and C8 positions (B2-type) and the C4 and C6 positions (B5-type) in the terminal units of the PAC. A quenching assay indicated that AzPAC interacted with IAV membrane proteins, hemagglutinin and neuraminidase. Additionally, circular dichroism analysis indicated that AzPAC affected the change in the secondary structure rate of the viral membrane proteins. AzPAC was able to impair the infective process of IAVs via direct interaction with their viral membrane proteins. These results indicate that A. zerumbet is an invaluable bioresource for the development of preventive drugs against IAV infection.
How a ball free to orbit in a circular track mitigates the galloping of a square prism
Authors: Selwanis Michael , Franzini Guilherme Rosa , Béguin Cédric , Gosselin Frédérick P. 
Published: October 2021

Abstract
Transverse galloping is a type of flow-induced vibration (FIV) that leads to critical design considerations for engineering structures. A purely nonlinear energy sink (NES) composed of a ball free to rotate in a circular track experimentally mitigated the galloping of a square in a previous study. The current study introduces a model for simulating the dynamics of the square prism coupled with a ball-in-track (BIT) NES and predicting the system behaviour at high flow speeds beyond the limits of the previously presented experiments. Numerical simulations employ the fitting of experimental data as inputs to define parameters. Wind tunnel static experiments provide the galloping force coefficient [[EQUATION]] relative to the prism angle of attack. Additionally, free rotation tests allow evaluating the ball damping coefficient [[EQUATION]] as a function of its mass and the NES track radius. The result of the rotation tests provides a critical angular speed beyond which the ball damping increases non-linearly. We point out the damping variation as an advantage of the BIT-NES; less damping at low angular velocities helps the ball start its rotation, while relatively large damping at higher speeds dissipates more energy from the vibrating system. Numerical results exhibit four response modes for the NES; oscillatory at low flow speeds, intermittent within a small range of higher flow speeds, rotational at higher flow speeds, and ineffective regime at flow speeds out of the NES effective range. Modelling the primary mass as a parametric excitation source for the NES provides an analytical estimation of the boundary between the oscillatory and intermittent regimes. Furthermore, we advance an analytical analysis of the power flow across the integrated prism-NES system to explain the NES behaviour and predict the limit of its effective range.
Hybrid Approach to Implement Multi-robotic Navigation System Using Neural Network, Fuzzy Logic and Bio-inspired Optimization Methodologies
Authors: Ayub Shahanaz , Singh Navneet , Hussain Md. Zair , Ashraf Mohd , Singh Dinesh Kumar , Haldorai Anandakumar 
Published: October 2021

Abstract
Mobile robots have been increasingly popular in a variety of industries in recent years due to their ability to move in variable situations and perform routine jobs effectively. Path planning, without a dispute, performs a crucial part in multi-robot navigation, making it one of the very foremost investigated issues in robotics. In recent times, meta-heuristic strategies have been intensively investigated to tackle path planning issues in the similar way that optimizing issues were handled, or to design the optimal path for such multi-robotics to travel from the initial point to such goal. The fundamental purpose of portable multi-robot guidance is to navigate a mobile robot across a crowded area from initial point to target position while maintaining a safe route and creating optimum length for the path. Various strategies for robot navigational path planning were investigated by scientists in this field. This work seeks to discuss bio-inspired methods that are exploited to optimize hybrid neuro-fuzzy analysis which is the combination of neural network and fuzzy logic is optimized using the Particle Swarm optimization technique (PSO) in real-time scenarios. Several optimization approaches of bio-inspired techniques are explained briefly. Its simulation findings, which are displayed for two simulated scenarios reveal that hybridization increases multi-robot navigation accuracy in terms of navigation duration and length of the path.
Thermal Wave Imaging for Detection of Osteoporosis
Authors: R Prathipa , R Ramadevi , V Chinnammal , S Rajalakshmi , I Poonkuzhali 
Published: October 2021

Abstract
Osteoporosis is a clinical sickness wherein the bones end up brittle and volatile because of tissue loss, which is usually caused by hormonal changes or a calcium or vitamin D deficiency. Osteoporosis has neither clinical signs nor symptoms, until some fracture occur. The aim of our project is to predict bone brittleness in order to detect osteoporosis using Image processing techniques. The objective measurement of bone mineral density (BMD), is presently accepted as the best indicator of osteoporosis fractures. For measuring and assessing biomaterials, thermal wave imaging is a potential , non-invasive, non-contact and safe imaging method.. Thermal wave imaging has the unique ability to measure physiological changes. The thermal images of bone are taken and removal of noise is carried out and undergone stationary wavelets transform process to improve the resolution of edges. The result shows that Artificial Neural Network is capable of predicting the brittleness of the bone using Regression in Machine Learning.
A DFT Analysis of Electronic, Reactivity, and NLO responses of a Reactive Orange Dye: the Role of Hartree-fock Exchange Corrections
Authors: Fonseca Sávio , Santos Lucas , Pereira Regina , Modesto-Costa Lucas , Cunha Antônio da , Siqueira Marcelo , Carvalho Francisco , Filho Tarciso Andrade , Gester Rodrigo 
Published: October 2021

Abstract
An experimental and theoretical study based on DFT/TD-DFT approximations is presented to understand the nature of electronic excitations, reactivity, and NLO properties of reactive orange 16 dye (RO16), an azo chromophore widely used in textile and pharmacological industries. The results show that the solvent has a considerable influence on the electronic properties of the material.

According to experimental results, the absorption spectrum is noticed by four intense transitions, which have been identified as $\pi\rightarrow\pi^*$ states using TD-DFT calculations. However, the TD-DFT results reveal a weak $n\rightarrow\pi^*$ in the low-lying spectral region. Continuum models of solvation indicate that these states suffer bathochromic and hypsochromic shifts, respectively.

However, the expected blue shift for the absorption $n\rightarrow\pi^*$ is only described using long-range or dispersion-corrected DFT methods. RO16 is classified as a strong electrophilic system ($\omega > 1.5$ eV). From vacuum to solvent, the environment is active and changes the nucleophilic status from strong to moderate nucleophile ($2.0 \leq N \leq 3.0$ eV). The results also suggest that all electrical constants are strongly dependent on long-rang and Hartree-Fock exchange contributions, and the absence of these interactions gives results far from reality. In particular, the results for the NLO response show that the chromophore presents a potential application in this field, with a low refractive index, and first-hyperpolarizability ca. 214 times bigger than the value usually reported for urea ($\beta = 0.34 \times 10^{-30}$ esu), which is a standard NLO material. Concerning the solvent effects, the results indicate that $\beta_\textrm{total}$ increases ca. 180\% regarding the gas-phase value. The results suggest RO16 is a potential compound in NLO applications.
Predictors of Citation Rates in High Impact Glioblastoma Trials
Authors: Jamjoom Ammer M , Jamjoom Abdulhakim B 
Published: October 2021

Abstract
Background

Clinical trials are at the top of research study designs and tend to attract high citation numbers. Glioblastoma multiforme (GBM) is a multidisciplinary disease that continues to be the subject of peak research interest. The literature relating to predictors of citation rates in clinical trials in general remains limited. We aim to identify the factors that influence citation numbers in high impact GBM trials.
Methods

The 100 most cited published GBM trials were identified and reviewed. The primary analysis was correlating articles citation numbers with various trial and publication-related predictors using Pearson correlation coefficient. The secondary analysis was comparing the mean citation numbers for the different subgroups using mean difference test.
Results

The median (range) citation numbers for the selected 100 trials were 349 (135- 16384). The primary analysis showed significant correlation between articles citation numbers and study population (P=0.024), trial phase (P=0.0427) and journal’s IF (P<0.0001). The secondary analysis demonstrated significantly higher mean citation numbers in trials with the following features: study population ≥ 115 (P=0.0208), phase III (P=0.0372), treatment protocol that included radiotherapy (RT) (P=0.0189) and temozolomide (TMZ) (P=0.0343), journal’s IF ≥ 14.9 (P=0.02) and general medical journals (P=0.28).
Conclusions

The most significant predictors of citation rates in high impact GBM trials were study population, trial phase, and journal IF. The treatment protocol was a positive predictor when it included the currently widely accepted treatment modalities (RT and TZM). Randomization, age of publication as well as the numbers of arms, authors, centres, countries, and references were not significant predictors. Increasing awareness of the factors that could affect citations may be useful to researchers undertaking clinical trials.
An Enhanced Hybrid Springback Compensation Approach: Springback Path – Displacement Adjustment Method For Complex Shaped Products of Sheet Metal Forming
Authors: Gong Zhihui , Singh Mandeep , Fang Bohao , Wei Dongbin 
Published: October 2021

Abstract
Springback compensation is critical in sheet metal forming. Advanced techniques have been adopted in the design stage of various sheet metal forming processes, e.g. stamping, some of which are for complex shaped products. However, the currently available numerical approaches are not always sufficiently accurate and reliable. To improve the accuracy of springback compensation, an enhanced hybrid springback compensation method named Springback Path – Displacement Adjustment (SP-DA) method has been developed in this study based on the well-known conventional displacement adjustment (DA) method. Its effectiveness is demonstrated using FEM analysis of low, medium and high strength steels adopted in automobile industry, in which a symmetrical model owning geometry complexity similar to an auto body panel was established. The results show this new enhanced SP-DA method is able to significantly improve the accuracy of springback compensation comparing to conventional displacement adjustment technique.
Effects of left atrial function on pulmonary arterial pressure in acute myocardial infarction, hypertrophic and dilated cardiomyopathy
Authors: Kim Minjeong , Chung Hyemoon , Kim In-Soo , Park Chul Hwan , Rim Se-Joong , Choi Eui-Young 
Published: October 2021

Abstract
Aims: To investigate the differential contribution of the left atrial (LA) function and left ventricular (LV) fibrosis to pulmonary arterial systolic pressure (PASP) in reperfused acute myocardial infarction (AMI), hypertrophic cardiomyopathy (HCM), and dilated cardiomyopathy (DCM). Methods and Results: Data of 370 patients with HCM (n=133), reperfused AMI (n=123), and DCM (n=114) who underwent both echocardiography and cardiovascular magnetic resonance (CMR) were comprehensively reviewed. Phasic LA volumes, LA-global longitudinal strain (GLS), and extracellular volume fraction (ECV) of LV were measured using CMR. E/e’ was correlated with PASP in all groups; however, the predicted value was significantly attenuated after adjusting for LA volume and LA strain in HCM and DCM, but remained significant in AMI. The E/e’/LA-GLS was related to PASP in HCM (p=0.01) and DCM (p=0.03) independent of LA volume index and E/e', but not in AMI. In DCM, ECV was significantly related to PASP (p<0.001) independent of LA volume index and E/e’. When subdivided according to the linear regression between PASP and E/e’, patients in the discrepantly high PASP group had lower total emptying fraction and reservoir fraction of left atrium in HCM and DCM but not in AMI compared to the good correlation group. Conclusions: The LA function in HCM and DCM and LV fibrosis in DCM correlated with PASP independent of E/e’ and LA size, contrary to that in AMI. These results suggest the presence of atrial myopathy in non-ischemic cardiomyopathies and usefulness of ECV measurement in DCM for the comprehensive evaluation of LV diastolic function.
Validation of a transient dynamical downscaling simulation approach with multi-model ensemble-based GCM bias corrections
Authors: Xu Zhongfeng , Han Ying , Tam Chi-Yung , Yang Zong-Liang , Fu Congbin 
Published: October 2021

Abstract
Dynamical downscaling is the most widely used physics-based approach to obtaining fine-scale weather and climate information. However, traditional dynamical downscaling approaches are often degraded by biases in the large-scale forcing. To improve the confidence in future projection of regional climate, we used a novel bias-corrected global climate model (GCM) dataset to drive a regional climate model (RCM) over the period for 1980–2014. The dynamical downscaling simulations driven by the original GCM dataset (MPI-ESM1-2-HR model) (hereafter WRF_GCM), the bias-corrected GCM (hereafter WRF_GCMbc) are validated against that driven by the European Centre for Medium-Range Weather Forecasts Reanalysis 5 dataset (hereafter WRF_ERA5), respectively. The results suggest that, compared with the WRF_GCM, the WRF_GCMbc shows a 50–90% reduction in RMSEs of the climatological mean of downscaled variables (e.g. temperature, precipitation, wind, relative humidity). Similarly, the WRF_GCMbc also shows improved performance in simulating the interannual variability of downscaled variables. The RMSEs of interannual variances of downscaled variables are reduced by 30–60%. An EOF analysis suggests that the WRF_GCMbc can successfully reproduce the dominant tri-pole mode in the interannual summer precipitation variations observed over eastern China as opposed to the mono-pole precipitation pattern simulated by the WRF_GCM. Such improvements are primarily caused by the correct simulation of the location of the western North Pacific subtropical high by the WRF_GCMbc due to the GCM bias correction.
Using Procedural And Conceptual Colour Stimulation-Game As an Instructional Gizmo For Nigerian Students
Authors: Olubunmi Odewumi Michael 
Published: October 2021

This research study focused on investigating on the effect of colour stimulation-game on Nigerian Junior secondary school creative arts by adopting quasi-experimental research design with 60 junior secondary schools of three co-educational, from Private, Public and Federal Secondary Schools using simple random sampling technique to randomly select The three secondary schools assigned to both experimental and control groups. With the aid of two instruments which were The Colour Stimulation-game and Colour Stimulation-Game Achievement Test (CSGAT), the data was collected. Frequency counts and percentage distribution, mean, standard deviation, independent t-test, ANOVA and ANCOVA were used to analyse the data demographic information, the research question and the hypothesis generated respectively. The researcher found out that the students taught with Stimulus perform better after treatment than the student taught with conventional teaching method, students taught with Colour Stimulus game performed better when exposed to treatment than their students taught with conventional teaching method and female students taught with Colour Stimulus game performed better than their male students. It was recommended that that creative arts instructors should utilizes, colour stimuli game and reducing conventional method do as to impact the appropriates knowledge for studentsKeywords: Colour Stimulation-Game, Colour, Game and instruction, Game, Significant in games