bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing Risk of Service Failures in Heavy Haul Rail Lines: A Hybrid Approach for Imbalanced Data
Authors: Ghofrani Faeze , Sun Hongyue , He Qing 
Published: January 2021

AbstractAn incident in which a rail defect of size over a threshold value is noticed and the track is taken out of service is known as a service failure. This article aims at building accurate prediction models with binary outcome for risk of service failures on heavy haul rail segments. An analysis of the factors that influence the risk of a service failure is conducted and quantitative models are developed to predict locations where service failures are most likely to occur until the next inspection. To this end, data are collected from a Class I U.S. Railroads for six years from 2011 to 2016. Four prediction models (i.e., logistic regression, decision tree, multilayer perceptron, and gradient boosting classifier) are implemented and their results are compared. To account for the imbalanced classes between the normal operation and service failure, two treatments have been used including undersampling and oversampling. To improve the model performance, the parameters of each method are tuned using random search hyperparameter optimization. Later, bootstrap aggregation (or bagging) is incorporated into each method. The findings of the study show that the prediction performance is the highest when using bagging and oversampling as treatments with gradient boosting method. It was also identified that gross tonnage, presence of geometry defects, ambient temperature, segment length, and rail defect presence are the most important factors for predicting the risk of service failures. The results of this study are useful for railroads to develop effective strategies for rail inspections, preventive maintenance, and capital planning.
Whole‐genome characterization of chronological age‐associated changes in methylome and circular RNAs in moso bamboo (Phyllostachys edulis) from vegetative to floral growth
Authors: Zhang Zeyu , Wang Huihui , Wang Yongsheng , Xi Feihu , Wang Huiyuan , Kohnen Markus V. , Gao Pengfei , Wei Wentao , Chen Kai , Liu Xuqing , Gao Yubang , Han Ximei , Hu Kaiqiang , Zhang Hangxiao , Zhu Qiang , Zheng Yushan , Liu Bo , Ahmad Ayaz , Hsu Yau‐Heiu , Jacobsen Steven E. , Gu Lianfeng 
Published: January 2021

SummaryIn mammals, DNA methylation is associated with aging. However, age‐related DNA methylation changes during phase transitions largely remain unstudied in plants. Moso bamboo (Phyllostachys edulis) requires a very long time to transition from the vegetative to the floral phase. To comprehensively investigate the association of DNA methylation with aging, we present here single‐base‐resolution DNA methylation profiles using both high‐throughput bisulfite sequencing and single‐molecule nanopore‐based DNA sequencing, covering the long period of vegetative growth and transition to flowering in moso bamboo. We discovered that CHH methylation gradually accumulates from vegetative to reproductive growth in a time‐dependent fashion. Differentially methylated regions, correlating with chronological aging, occurred preferentially at both transcription start sites and transcription termination sites. Genes with CG methylation changes showed an enrichment of Gene Ontology (GO) categories in ‘vegetative to reproductive phase transition of meristem’. Combining methylation data with mRNA sequencing revealed that DNA methylation in promoters, introns and exons may have different roles in regulating gene expression. Finally, circular RNA (circRNA) sequencing revealed that the flanking introns of circRNAs are hypermethylated and enriched in long terminal repeat (LTR) retrotransposons. Together, the observations in this study provide insights into the dynamic DNA methylation and circRNA landscapes, correlating with chronological age, which paves the way to study further the impact of epigenetic factors on flowering in moso bamboo.
25 Years of Session Rating of Perceived Exertion: Historical Perspective and Development
Authors: Foster Carl , Boullosa Daniel , McGuigan Michael , Fusco Andrea , Cortis Cristina , Arney Blaine E. , Orton Bo , Dodge Christopher , Jaime Salvador , Radtke Kim , van Erp Teun , de Koning Jos J. , Bok Daniel , Rodriguez-Marroyo Jose A. , Porcari John P. 
Published: January 2021

The session rating of perceived exertion (sRPE) method was developed 25 years ago as a modification of the Borg concept of rating of perceived exertion (RPE), designed to estimate the intensity of an entire training session. It appears to be well accepted as a marker of the internal training load. Early studies demonstrated that sRPE correlated well with objective measures of internal training load, such as the percentage of heart rate reserve and blood lactate concentration. It has been shown to be useful in a wide variety of exercise activities ranging from aerobic to resistance to games. It has also been shown to be useful in populations ranging from patients to elite athletes. The sRPE is a reasonable measure of the average RPE acquired across an exercise session. Originally designed to be acquired ∼30 minutes after a training bout to prevent the terminal elements of an exercise session from unduly influencing the rating, sRPE has been shown to be temporally robust across periods ranging from 1 minute to 14 days following an exercise session. Within the training impulse concept, sRPE, or other indices derived from sRPE, has been shown to be able to account for both positive and negative training outcomes and has contributed to our understanding of how training is periodized to optimize training outcomes and to understand maladaptations such as overtraining syndrome. The sRPE as a method of monitoring training has the advantage of extreme simplicity. While it is not ideal for the precise recording of the details of the external training load, it has large advantages relative to evaluating the internal training load.
Placental site trophoblastic tumour: five challenges of patient clinical management
Authors: Peixinho Catarina , Almeida Amélia , Bartosch Carla , Cruz Pires Mónica 
Published: January 2021

Placental site trophoblastic tumour is a rare form of gestational trophoblastic disease accounting for about 1%–2% of all trophoblastic tumours. Diagnosis and management of placental site trophoblastic tumour can be difficult.We report a case of a 30-year-old woman diagnosed with a placental site trophoblastic tumour and identify the challenges in diagnosis and treatment of this rare situation. The presenting sign was abnormal vaginal bleeding that started 3 months after delivery. Image exams revealed an enlarged uterus with a heterogeneous mass, with vesicular pattern, and the increased vascularisation serum human chorionic gonadotropin level was above normal range. The histological diagnosis was achieved through hysteroscopic biopsy. Staging exams revealed pulmonary micronodules. The patient was successfully treated with hysterectomy and chemotherapy. The latest follow-up (37 months after diagnosis) was uneventful, and the patient exhibited no signs of recurrence or metastasis.
An 11-week school-based ‘health education through football programme’ improves health knowledge related to hygiene, nutrition, physical activity and well-being—and it’s fun! A scaled-up, cluster-RCT with over 3000 Danish school children aged 10–12 years old
Authors: Larsen Malte Nejst , Elbe Anne-Marie , Madsen Mads , Madsen Esben Elholm , Ørntoft Christina , Ryom Knud , Dvorak Jiri , Krustrup Peter 
Published: January 2021

ObjectivesOur large-scale cluster randomised controlled trial aimed to investigate the effects on health knowledge and enjoyment of an 11 week ‘health education through football’ programme for children aged 10–12 years old.Methods3127 Danish school children (49% girls) aged 10–12 years from a total of 154 schools located in 63% of the Danish municipalities (69 of 98) took part in the analysis. A 5:1 cluster randomisation was performed at school level for the intervention group (IG) or the control group (CG). The twice-weekly 45 min intervention was the ‘11 for Health in Denmark’ programme, which includes health education, football drills and small-sided games. The health education element focused on hygiene, nutrition, physical activity and well-being. Outcomes: The participants completed a 34-item multiple-choice computer-based health knowledge questionnaire preintervention and postintervention. IG also evaluated whether the programme was enjoyable.ResultsBetween-group differences (p<0.05) were observed in overall health knowledge in favour of IG (+7.2% points, 95% CI 6.1% to 8.4%, effect size, ES:0.59), with similar effects for girls (+7.4% points, 95% CI 5.9% to 9.0%, ES:0.57) and for boys (+7.0% points, 95% CI 5.3% to 8.7%, p<0.05, ES:0.51). Marked between-group differences were observed in favour of IG, for health knowledge related to hygiene (IG vs CG:+13.9% points, 95% CI 11.1% to 16.7%, ES:0.53), nutrition (+10.3% points, 95% CI 8.5% to 12.1%, ES:0.53), physical activity (+5.9% points, 95% CI 4.1% to 7.7%, ES:0.36) and well-being (+4.4% points, 95% CI 2.7% to 6.1%, ES:0.28). Both girls and boys gave the programme moderate to high scores for enjoyment (3.6±1.0 and 3.7±1.1, respectively).ConclusionHealth education through sport, using the ‘11 for Health’ model, was enjoyable for girls and boys aged 10–12 years old, and improved health knowledge related to hygiene, nutrition, physical activity and well-being.
Molecular profiling of advanced non-small cell lung cancer in the era of immunotherapy approach: a multicenter Italian observational prospective study of biomarker screening in daily clinical practice
Authors: Vavala Tiziana , Malapelle Umberto , Veggiani Claudia , Ludovini Vienna , Papotti Mauro , Leone Alvaro , Graziano Paolo , Minari Roberta , Bono Francesca , Sapino Anna , Manotti Laura , Troncone Giancarlo , Pisapia Pasquale , Girlando Salvatore , Buffoni Lucio , Righi Luisella , Colantonio Ida , Bertetto Oscar , Novello Silvia 
Published: January 2021

AimsHeterogeneous implementation of molecular tests in current diagnostic algorithm at a European and international level is emerging as a major issue for efficient lung cancer molecular profiling.MethodsFrom May 2017 until October 2017, N=1612 patients referring to 13 Italian institutions were selected, at advanced stage non-small cell lung cancer (NSCLC), and prospectively evaluated. Principal endpoints were: the percentage of diagnoses performed on cytological and histological material, the proportion of requests for epidermal growth factor receptor (EGFR) mutational status, and resistance mutations detected on tissue and/or liquid biopsy samples after first-generation or second-generation tyrosine kinase inhibitors, the proportion of requests for anaplastic lymphoma kinase (ALK) gene rearrangements, ROS proto-oncogene 1 (ROS1) and Kirsten Rat Sarcoma (KRAS) determinations, the proportion of requests for programmed death-ligand1 (PD-L1) evaluation and, finally, the different assays used for the detection of EGFR mutations, ALK and ROS1 gene rearrangements and PD-L1 expression.ResultsOf 1325 patients finally included, only 50.8% requests were related to driver mutations with target agents already available in first-line at that preplanned time, while 49.2% were associated with PD-L1, ROS1, KRAS and others. Multiplex genomic assays (such as next-generation sequencing) were considered by all participating centres.ConclusionsTo the best of our knowledge, this is the first study in a ‘real-life daily practice’ involving both pathologists and oncologists evaluating routinely workflow and trends towards improvements in molecular requests. Collected data aim to describe the applied algorithms and evolution of molecular screening for stage IV NSCLC in clinical practice.
High levels of immunosuppression are related to unfavourable outcomes in hospitalised patients with rheumatic diseases and COVID-19: first results of ReumaCoV Brasil registry
Authors: Marques Claudia Diniz Lopes , Kakehasi Adriana Maria , Pinheiro Marcelo Medeiros , Mota Licia Maria Henrique , Albuquerque Cleandro Pires , Silva Carolina Rocha , Santos Gabriela Porfirio Jardim , Reis-Neto Edgard Torres , Matos Pedro , Devide Guilherme , Dantas Andrea , Giorgi Rina Dalva , Omura Felipe , Marinho Adriana de Oliveira , Valadares Lilian David Azevedo , Melo Ana Karla G , Ribeiro Francinne Machado , Ferreira Gilda Aparecida , Santos Flavia Patricia de Sena , Ribeiro Sandra Lucia Euzebio , Andrade Nicole Pamplona Bueno , Yazbek Michel Alexandre , Souza Viviane Angelina de , Paiva Eduardo S , Azevedo Valderilio Feijo , Freitas Ana Beatriz Santos Bacchiega de , Provenza José Roberto , Toledo Ricardo Acayaba de , Fontenelle Sheilla , Carneiro Sueli , Xavier Ricardo , Pileggi Gecilmara Cristina Salviato , Reis Ana Paula Monteiro Gomides 
Published: January 2021

ObjectivesTo evaluate risk factors associated with unfavourable outcomes: emergency care, hospitalisation, admission to intensive care unit (ICU), mechanical ventilation and death in patients with immune-mediated rheumatic disease (IMRD) and COVID-19.MethodsAnalysis of the first 8 weeks of observational multicentre prospective cohort study (ReumaCoV Brasil register). Patients with IMRD and COVID-19 according to the Ministry of Health criteria were classified as eligible for the study.Results334 participants were enrolled, a majority of them women, with a median age of 45 years; systemic lupus erythematosus (32.9%) was the most frequent IMRD. Emergency care was required in 160 patients, 33.0% were hospitalised, 15.0% were admitted to the ICU and 10.5% underwent mechanical ventilation; 28 patients (8.4%) died. In the multivariate adjustment model for emergency care, diabetes (prevalence ratio, PR 1.38; 95% CI 1.11 to 1.73; p=0.004), kidney disease (PR 1.36; 95% CI 1.05 to 1.77; p=0.020), oral glucocorticoids (GC) (PR 1.49; 95% CI 1.21 to 1.85; p<0.001) and pulse therapy with methylprednisolone (PR 1.38; 95% CI 1.14 to 1.67; p=0.001) remained significant; for hospitalisation, age >50 years (PR 1.89; 95% CI 1.26 to 2.85; p=0.002), no use of tumour necrosis factor inhibitor (TNFi) (PR 2.51;95% CI 1.16 to 5.45; p=0.004) and methylprednisolone pulse therapy (PR 2.50; 95% CI 1.59 to 3.92; p<0.001); for ICU admission, oral GC (PR 2.24; 95% CI 1.36 to 3.71; p<0.001) and pulse therapy with methylprednisolone (PR 1.65; 95% CI 1.00 to 2.68; p<0.043); the two variables associated with death were pulse therapy with methylprednisolone or cyclophosphamide (PR 2.86; 95% CI 1.59 to 5.14; p<0.018).ConclusionsAge >50 years and immunosuppression with GC and cyclophosphamide were associated with unfavourable outcomes of COVID-19. Treatment with TNFi may have been protective, perhaps leading to the COVID-19 inflammatory process.
Efficacy and safety of rituximab in peripheral ulcerative keratitis associated with rheumatoid arthritis
Authors: Bonnet Isabelle , Rousseau Antoine , Duraffour Pierre , Pouchot Jacques , Nguyen Chi Duc , Gabison Eric , Seror Raphaele , Marotte Hubert , Mariette Xavier , Nocturne Gaetane 
Published: January 2021

ObjectivePeripheral ulcerative keratitis (PUK) is a rare but severe ocular complication of rheumatoid arthritis (RA). It can be considered as an ocular manifestation of rheumatoid vasculitis (RV). Our case series aimed to evaluate the efficacy of rituximab (RTX) for PUK occurring in patients with RA.MethodsStudy population were patients with RA-associated PUK treated with RTX 1000 mg on days 1 and 15 at least once after the diagnosis. We identified patients referred to the rheumatology and ophthalmology departments of our hospital between February 2014 and June 2020. We also included patients referred by their specialist after being contacted through the Club Rhumatismes et Inflammation. Demographic data and clinical and biological features were retrospectively collected.ResultsWe included seven patients (three men and four women, median age 58 years). All but one had a long-standing RA with a median disease duration of 13.9 years (IQR 0–30.2). RA was erosive in six out of seven patients. All patients had rheumatoid factors and anticitrullinated peptides antibodies were positive in six of them. PUK was complicated by corneal perforation in three patients and required surgery. After a median follow-up of 29.8 months (IQR 5–75), corneal inflammation was controlled in all patients. PUK recurred in one patient, 8 months after a single infusion of RTX. 71% of the patients presented a good articular response. No patient developed other manifestations of RV. No serious adverse event related to RTX was observed.ConclusionRTX appears to be an efficient and safe therapeutic option in the treatment of RA-associated PUK.
Leveraging a health information exchange to examine the accuracy of self-report emergency department utilization data among hospitalized injury survivors
Authors: Whiteside Lauren K , Vrablik Marie C , Russo Joan , Bulger Eileen M , Nehra Deepika , Moloney Kathleen , Zatzick Douglas F 
Published: January 2021

BackgroundAccurate acute care medical utilization history is an important outcome for clinicians and investigators concerned with improving trauma center care. The objective of this study was to examine the accuracy of self-report emergency department (ED) utilization compared with utilization obtained from the Emergency Department Information Exchange (EDIE) in admitted trauma surgery patients with comorbid mental health and substance use problems.MethodsThis is a retrospective cohort study of 169 injured patients admitted to the University of Washington’s Harborview Level I Trauma Center. Patients had high levels of post-traumatic stress disorder and depressive symptoms, suicidal ideation and alcohol comorbidity. The investigation used EDIE, a novel health technology tool that collects information at the time a patient checks into any ED in Washington and other US states. Patterns of EDIE-documented visits were described, and the accuracy of injured patients’ self-report visits was compared with EDIE-recorded visits during the course of the 12 months prior to the index trauma center admission.ResultsOverall, 45% of the sample (n=76) inaccurately recalled their ED visits during the past year, with 36 participants (21%) reporting less ED visits than EDIE indicated and 40 (24%) reporting more ED visits than EDIE indicated. Patients with histories of alcohol use problems and major psychiatric illness were more likely to either under-report or over-report ED health service use.DiscussionNearly half of all patients were unable to accurately recall ED visits in the previous 12 months compared with EDIE, with almost one-quarter of patients demonstrating high levels of disagreement. The improved accuracy and ease of use when compared with self-report make EDIE an important tool for both clinical and pragmatic trial longitudinal outcome assessments. Orchestrated investigative and policy efforts could further examine the benefits of introducing EDIE and other information exchanges into routine acute care clinical workflows.Level of evidenceII/III.Trial registration numberClinicalTrials.govNCT02274688.
Seasonal and diurnal variations of back-calculated layer moduli in flexible pavement and FWD testing guidelines
Authors: Muslim Hamad Bin , Haider Syed Waqar , Chatti Karim 
Published: January 2021

Seasonal and diurnal variations can significantly impact falling weight deflectometer (FWD) measurements and, thus, deflection-based parameters such as back-calculated layer moduli. Therefore, it is necessary to evaluate and quantify these effects. The back-calculated layer moduli data from the Long-Term Pavement Performance Seasonal Monitoring Program study were analyzed within each climatic region. The effects of seasonal and diurnal changes were quantified and related to ambient temperatures were related to the development of general measurement guidelines. The HMA layer moduli showed minimal variation during the spring and fall seasons in every climatic region and were consistently higher based on the deflections measured before noon. However, temperature correction, generally applied to the HMA layer moduli, can eliminate the temperature impacts of the FWD measurements. Because the unbound layer moduli are back-calculated from the single measured deflection basins on the surface, temperature and moisture conditions at the time of measurements can affect the material properties. The base and subgrade moduli showed minimal variation within the temperature ranges of the spring and fall seasons. Therefore, such temperature within each climatic region may result in layer moduli values closest to their representative in-field conditions. In addition, the unbound layer showed no effect of time within a day, suggesting that FWD testing can be conducted at any time during the day. Based on the results, the preferred temperature ranges for FWD measurements are 55–70 °F and 65–75 °F in the freeze and non-freeze regions, respectively. FWD measurements can be conducted at any time during the day. The preferred seasons for testing are spring and fall in all climatic regions.
Determination of the asymmetry term strength in the n–A elastic scattering process using a nonlocal optical model
Authors: Sawalha A. , Jaghoub M.I. 
Published: January 2021

In previous works, the imaginary surface and (or) the imaginary volume depths of the optical potential were parametrized as linear functions of the projectile’s incident energy and neutron-proton asymmetry (N – Z)/A of the target nucleus. However, the obtained asymmetry strength parameters were not robust nor unique. In this work, we determine values for the strength parameters by simultaneously fitting 38 angular distribution data sets corresponding to neutron elastic scattering off chains of isotopes. For each isotopic chain, we considered the data sets that are measured at the same energy. This minimises the effect of the known energy dependence of the optical model and projects the dependence on the asymmetry term, which in turn leads to more reliable values of the strength parameters. To demonstrate the significance of the obtained strength values, we use the model to predict elastic angular distributions for neutron scattering off nuclei not considered in the χ2 analysis. Our theoretical angular distributions are in good agreement with the measured data and are also comparable to the predictions of local global models. In addition, our predicted total elastic and total reaction cross sections are in fair overall agreement with experiment. An additional result of this work is the determination of a global set of nonlocal parameters that describe neutron elastic scattering off nuclei that fall in the mass range 24 ≤ A ≤ 208 corresponding to incident neutron energies between ≈10–30 MeV.