bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engaging multi-stakeholder perspectives to identify dementia care research priorities
Authors: Patel Neela K. , Masoud Sara S. , Meyer Kylie , Davila Angelica V. , Rivette Sheran , Glassner Ashlie A. , James Deborah , White Carole L. 
Published: June 2021

Abstract
Objectives
The purpose of this study was to partner with stakeholders to identify gaps in care for persons living with dementia and their family caregivers and from this list, identify priorities for dementia care research.

Methods
Using a community-engaged research approach, a Stakeholder Advisory Council (SAC) consisting of diverse membership including persons living with dementia and family caregivers was convened. Through our work with the SAC, along with input from the wider network through a symposium, webinars, and an online learning community, gaps in dementia care and a list of topics for dementia care research was generated. This list was reduced to 46 topics for dementia care research and sent to stakeholders (persons living with dementia, family caregivers, and health/social care professionals in dementia care) to be prioritized by rating each of the 46 topics as “Not so important,” “Important,” or “Very important.” Priorities for dementia care were summarized by frequencies and proportions.

Results
A total of 186 participants completed the survey from August through October 2020, including 23 (12.4%) persons living with dementia, 101 (54.3%) family caregivers, and 62 (33.3%) health/social care professionals. Consistent across stakeholder groups was the focus on research on how best to support families following a diagnosis of dementia. Among persons living with dementia, research focused on support for continuing to live in their own homes was ranked as the highest priority, rated by 91.3% as “Very Important”. High priority research areas for family caregivers included interventions to slow cognitive decline (76.3%) as well as non-pharmacological approaches to manage behavioral symptoms (74.7%). The highest priority research topics for health/social care professionals were focused on the diagnosis including benefits of an early diagnosis (71.4%), how best to deliver the diagnosis (70.9%), and supports needed following a diagnosis (78.6%).

Conclusions
This project draws on the strengths of its multi-stakeholder perspective to support patient-centered outcomes research. Findings are intended to inform those who conduct research and those who fund research about which research topics stakeholders believe are most important and thus have greatest potential to improve the quality of life among people living with dementia and their families.
Extradural anterior clinoidectomy in surgical management of clinoidal meningiomas
Authors: El-Bahy K. , Ibrahim Ashraf M. , Abdelmohsen Ibrahim , Sabry Hatem A. 
Published: June 2021

Abstract
Background
Despite the recent advances in skull base surgery, microsurgical techniques, and neuroimaging, yet surgical resection of clinoidal meningiomas is still a major challenge. In this study, we present our institution experience in the surgical treatment of anterior clinoidal meningiomas highlighting the role of extradural anterior clinoidectomy in improving the visual outcome and the extent of tumor resection. This is a prospective observational study conducted on 33 consecutive patients with clinoidal meningiomas. The surgical approach utilized consisted of extradural anterior clinoidectomy, optic canal deroofing with falciform ligament opening in all patients. The primary outcome assessment was visual improvement and secondary outcomes were extent of tumor resection, recurrence, and postoperative complications.

Results
The study included 5 males and 28 females with mean age 49.48 ± 11.41 years. Preoperative visual deficit was present in 30 (90.9%) patients. Optic canal involvement was present in 24 (72.7%) patients, ICA encasement was in 16 (48.5%), and cavernous sinus invasion in 8 (24.2%). Vision improved in 21 patients (70%), while 6 patients (20%) had stationary course and 1 patient (3%) suffered postoperative new visual deterioration. Gross total resection was achieved in 24 patients (72.7%). The main factors precluding total removal were cavernous sinus involvement and ICA encasement. Mortality rate was 6.1%; mean follow-up period was 27 ± 13 months.

Conclusions
In this series, the use of extradural anterior clinoidectomy provided a favorable visual outcome and improved the extent of resection in clinoidal meningioma patients.
A comparative study on intraocular pressure under various anesthetics in cynomolgus monkeys (Macaca fascicularis)
Authors: Lee Hong-Soo , Kim Da-Hee , Kim Sung-Hwan , Kang Min-Sung , Suh Han Na 
Published: June 2021

Abstract
Background
Nonhuman primates (NHPs) are superior model for ocular research due to its morphological and physiological similarities with humans. Thus, the effect of four different anesthetic combinations [ketamine (10 mg/kg), ketamine + xylazine (7 + 0.6 mg/kg), zoletil (4 mg/kg), and zoletil + xylazine (4 + 0.2 mg/kg)] on intraocular pressure (IOP) was determined in cynomolgus monkeys.

Results
The administration of ketamine + xylazine or zoletil + xylazine resulted in lower IOP compared to ketamine or zoletil alone. Moreover, the IOP in male monkeys was higher than in females. The difference between the right and left eye was not found.

Conclusions
Anesthetics affected the IOP, and gender differences should be considered when measuring the IOP of nonhuman primates (NHPs).
Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia
Authors: Myers Regina M. , Li Yimei , Barz Leahy Allison , Barrett David M. , Teachey David T. , Callahan Colleen , Fasano Christina C. , Rheingold Susan R. , DiNofia Amanda , Wray Lisa , Aplenc Richard , Baniewicz Diane , Liu Hongyan , Shaw Pamela A. , Pequignot Edward , Getz Kelly D. , Brogdon Jennifer L. , Fesnak Andrew D. , Siegel Donald L. , Davis Megan M. , Bartoszek Chelsie , Lacey Simon F. , Hexner Elizabeth O. , Chew Anne , Wertheim Gerald B. , Levine Bruce L. , June Carl H. , Grupp Stephan A. , Maude Shannon L. 
Published: June 2021

PURPOSE CD19-targeted chimeric antigen receptor (CAR)–modified T cells demonstrate unprecedented responses in B-cell acute lymphoblastic leukemia (B-ALL); however, relapse remains a substantial challenge. Short CAR T-cell persistence contributes to this risk; therefore, strategies to improve persistence are needed. METHODS We conducted a pilot clinical trial of a humanized CD19 CAR T-cell product (huCART19) in children and young adults with relapsed or refractory B-ALL (n = 72) or B-lymphoblastic lymphoma (n = 2), treated in two cohorts: with (retreatment, n = 33) or without (CAR-naive, n = 41) prior CAR exposure. Patients were monitored for toxicity, response, and persistence of huCART19. RESULTS Seventy-four patients 1-29 years of age received huCART19. Cytokine release syndrome developed in 62 (84%) patients and was grade 4 in five (6.8%). Neurologic toxicities were reported in 29 (39%), three (4%) grade 3 or 4, and fully resolved in all cases. The overall response rate at 1 month after infusion was 98% (100% in B-ALL) in the CAR-naive cohort and 64% in the retreatment cohort. At 6 months, the probability of losing huCART19 persistence was 27% (95% CI, 14 to 41) for CAR-naive and 48% (95% CI, 30 to 64) for retreatment patients, whereas the incidence of B-cell recovery was 15% (95% CI, 6 to 28) and 58% (95% CI, 33 to 77), respectively. Relapse-free survival at 12 and 24 months, respectively, was 84% (95% CI, 72 to 97) and 74% (95% CI, 60 to 90) in CAR-naive and 74% (95% CI, 56 to 97) and 58% (95% CI, 37 to 90) in retreatment cohorts. CONCLUSION HuCART19 achieved durable remissions with long-term persistence in children and young adults with relapsed or refractory B-ALL, including after failure of prior CAR T-cell therapy.
Gonadal Function Recovery in Patients With Advanced Hodgkin Lymphoma Treated With a PET-Adapted Regimen: Prospective Analysis of a Randomized Phase III Trial (AHL2011)
Authors: Demeestere Isabelle , Racape Judith , Dechene Julie , Dupuis Jehan , Morschhauser Franck , De Wilde Virginie , Lazarovici Julien , Ghesquieres Hervé , Touati Mohamed , Sibon David , Alexis Magda , Gac Anne-Claire , Moatti Hannah , Virelizier Emmanuelle , Maisonneuve Hervé , Pranger Delphine , Houot Roch , Fornecker Luc-Matthieu , Tempescul Adrian , André Marc , Casasnovas René-Olivier 
Published: June 2021

PURPOSE The prospective, randomized AHL2011 trial demonstrated that the use of the doxorubicin, bleomycin, vinblastine, and dacarbazine regimen (ABVD) after two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPPescalated) in early responders on the basis of a positron emission tomography (PET)–driven strategy was safe and minimized toxicity compared with standard 6 BEACOPPescalated cycles. This substudy investigated the benefit of this strategy in gonadal function and fertility in patients under 45 years old. METHODS Ovarian function was assessed by serum measurement of follicle-stimulating hormone (FSH), estradiol, and anti-müllerian hormone in women, and semen analysis, FSH, and testosterone levels were used to evaluate testicular function in men at baseline, end of treatment, and during 5 years of follow-up. RESULTS A total of 145 women and 424 men, enrolled between May 19, 2011, and April 29, 2014, were included. The risk of premature ovarian insufficiency (FSH > 24 IU/L) and of having a low ovarian reserve (anti-müllerian hormone < 0.5 ng/mL) was reduced after treatment in the PET-driven group (odds ratio [OR], 0.20; 95% CI, 0.08 to 0.50; P = .001 and OR, 0.15; 95% CI, 0.04 to 0.56, P = .005, respectively). Both parameters were correlated with age and dose of alkylating agents. However, no significant differences were observed in terms of pregnancy rates. Men in the PET-driven group had a higher recovery rate of sperm parameters after treatment compared with the standard BEACOPPescalated group, as well as a lower risk of severe testicular damage (OR, 0.26; 95% CI, 0.13 to 0.5; P < .0001) and a higher likelihood of achieving pregnancy (OR, 3.7; 95% CI, 1.4 to 9.3; P = .004). CONCLUSION Although both treatments affected ovarian reserve and spermatogenesis, the PET-driven strategy decreased the risk of gonadal dysfunction and infertility in advanced Hodgkin lymphoma.
Academic Performance in Adolescents Born to Mothers With Gestational Diabetes—A National Danish Cohort Study
Authors: Heldarskard Gerda Ferja , Spangmose Anne Lærke , Henningsen Anna-Karina Aaris , Wiingreen Rikke , Mortensen Erik Lykke , Gundersen Tina Wullum , Jensen Rikke Beck , Knorr Sine , Damm Peter , Forman Julie Lyng , Pinborg Anja , Clausen Tine Dalsgaard 
Published: June 2021

Abstract

Context
The prevalence of gestational diabetes mellitus (GDM) is increasing, and intrauterine hyperglycemia is suspected to affect offspring cognitive function.

Objective
We assessed academic performance by grade point average (GPA) in children aged 15 to 16 years at compulsory school graduation, comparing offspring exposed to GDM (O-GDM) with offspring from the background population (O-BP).

Methods
This register-based, cohort study comprised all singletons born in Denmark between 1994 and 2001 (O-GDM: n = 4286; O-BP: n = 501 045). Standardized and internationally comparable GPAs were compared in univariate and multivariable linear models. Main outcome measures included the adjusted mean difference in GPA. We also analyzed the probability of having a high GPA, a GPA below passing, and no GPA registered.

Results
O-GDM had a GPA of 6.29 (SD 2.52), whereas O-BP had a GPA of 6.78 (SD 2.50). The adjusted mean difference was –0.36 (95% CI, –0.44 to –0.29), corresponding to a Cohen’s D of 0.14. O-GDM had a lower probability of obtaining a high GPA (adjusted odds ratio [aOR] 0.68; 95% CI, 0.59 to 0.79), while their risk of obtaining a GPA below passing was similar to O-BP (aOR 1.20; 95% CI, 0.96 to 1.50). O-GDM had a higher risk of not having a GPA registered (aOR 1.38; 95% CI, 1.24 to 1.53).

Conclusion
Academic performance in O-GDM was marginally lower than in O-BP. However, this difference is unlikely to be of clinical importance.
Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women
Authors: Clendenen Tess V , Ge Wenzhen , Koenig Karen L , Afanasyeva Yelena , Agnoli Claudia , Bertone-Johnson Elizabeth , Brinton Louise A , Darvishian Farbod , Dorgan Joanne F , Eliassen A Heather , Falk Roni T , Hallmans Göran , Hankinson Susan E , Hoffman-Bolton Judith , Key Timothy J , Krogh Vittorio , Nichols Hazel B , Sandler Dale P , Schoemaker Minouk J , Sluss Patrick M , Sund Malin , Swerdlow Anthony J , Visvanathan Kala , Liu Mengling , Zeleniuch-Jacquotte Anne 
Published: June 2021

Abstract

Context
We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies.

Objective
This study assessed whether risk factors for breast cancer are correlates of AMH concentration.

Methods
This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population.

Results
Adjusting for age and cohort, AMH positively associated with age at menarche (P &lt; 0.0001) and parity (P = 0.0008) and inversely associated with hysterectomy/partial oophorectomy (P = 0.0008). Compared with women of normal weight, AMH was lower (relative geometric mean difference 27%, P &lt; 0.0001) among women who were obese. Current oral contraceptive (OC) use and current/former smoking were associated with lower AMH concentration than never use (40% and 12% lower, respectively, P &lt; 0.0001). We observed higher AMH concentrations among women who had had a benign breast biopsy (15% higher, P = 0.03), a surrogate for benign breast disease, an association that has not been reported. In analyses stratified by age (&lt;40 vs ≥40), associations of AMH with body mass index and OCs were similar in younger and older women, while associations with the other factors (menarche, parity, hysterectomy/partial oophorectomy, smoking, and benign breast biopsy) were limited to women ≥40 (P-interaction &lt; 0.05).

Conclusion
This is the largest study of AMH and breast cancer risk factors among women from the general population (not presenting with infertility), and it suggests that most associations are limited to women over 40, who are approaching menopause and whose AMH concentration is declining.
CBG Montevideo: A Clinically Novel SERPINA6 Mutation Leading to Haploinsufficiency of Corticosteroid-binding Globulin
Authors: Meyer Emily Jane , Spangenberg Lucía , Ramírez Maria José , De Sousa Sunita Maria Christina , Raggio Victor , Torpy David James 
Published: June 2021

Abstract
Corticosteroid-binding globulin (CBG) is the main transport protein for cortisol, binding up to 90% in a 1:1 ratio. CBG provides transport of cortisol within the circulation and targeted cortisol tissue delivery.
Here, we describe the clinically novel “CBG Montevideo” a SERPINA6 pathogenic variant that results in a 50% reduction in plasma CBG levels. This was associated with low serum total cortisol and clinical features of hypoglycemia, exercise intolerance, chronic fatigue, and hypotension in the proband, a 7-year-old boy, and his affected mother.
Previous reports of 9 human CBG genetic variants affecting either CBG concentrations or reduced CBG-cortisol binding properties have outlined symptoms consistent with attenuated features of hypocortisolism, fatigue, and hypotension. Here, however, the presence of hypoglycemia, despite normal circulating free cortisol, suggests a specific role for CBG in effecting glucocorticoid function, perhaps involving cortisol-mediated hepatic glucose homeostasis and cortisol-brain communication.
Provincializing Trans* Modernity
Authors: Garde Jonah I. 
Published: June 2021

Abstract
This article aims to disrupt notions of modernity deeply inscribed in the origin narrative of trans studies by thinking through the relationship between transgender, the transatlantic, and Europe. Drawing on Saidiya Hartman's and Christina Sharpe's Black feminist theorizing of the asterisk and the multiple meanings embedded in trans*, the article takes up the archives of European sexology to explore their entangled histories as well as their limitations. Through a critical reading of Der Steinachfilm that is attentive to its transgressive imaginary as well as its silenced colonial and racial subtext, the author aims to contribute to the necessary task of provincializing some of trans studies' dominant epistemologies.
Der Gelbschmied und Alchemist (?) vom Ringelhof
Authors: Kamber Pia , Kurzmann Peter , Gerber Yvonne 
Published: June 2021

Bei Bauarbeiten in der Basler Altstadtliegenschaft «Ringelhof» wurde 1939 ein Laborinventar aus der zweiten Hälfte des 13. Jahrhunderts entdeckt. Die frühe Datierung, die zeitliche Geschlossenheit des Inventars und eine Vielzahl bisher unbekannter Laborgefässe machen den Fund forschungsgeschichtlich ausserordentlich bedeutsam.
Zur Interpretation und Deutung der Gefässe wurden alchemistische Manuskripte des 13. und 14. Jahrhunderts beigezogen, die ähnliche Gerätschaften abbilden und auch benennen.
Die archäometrische Untersuchung der Gefässe und ihrer Inhalte ergab überraschenderweise, dass im Laboratorium ausschliesslich metallurgische Prozesse durchgeführt wurden. Dieser Befund ist deshalb so überraschend, weil sich unter den Gefässen eindeutige Destilliergefässe befinden. Diese wurden jedoch zweckentfremdet zur Durchführung von Reaktionen in der Schmelze verwendet, genauso wie eine Sublimierapparatur und andere Gefässe (Talglämpchen, Dreibeingefässe, Schüsseln, Schalen, sogar eine Napfkachel).
Das Vorkommen der Destilliergefässe lässt den Schluss zu, dass es in Basel oder der näheren Umgebung in jener Zeit wenigstens ein alchemistisches Laboratorium gegeben hat, in dem auch destilliert wurde.
Burkhardsche und Innere Stadtmauer - neu betrachtet
Authors: Matt Christoph Ph. , Rentzel Philippe 
Published: June 2021

Der vorliegende Aufsatz beschäftigt sich eingehend und unter verschiedenen Gesichtspunkten mit den beiden älteren Grossbasler Stadtmauern, der Burkhardschen aus dem späten 11. Jahrhundert und der Inneren Stadtmauer aus der 1. Hälfte des 13. Jahrhunderts.
Während von der ersten Stadtmauer Bau-Anlass und ungefähre Entstehungszeit bekannt sind, die Mauer archäologisch jedoch bis 1976 nirgends nachgewiesen werden konnte, fehlen bis heute historische Quellen zum Bau der Inneren Mauer, die sich im Stadtgefüge jedoch stets klar abzeichnete.
Bereits früher ausführlich publizierte Befunde von einzelnen Fundstellen werden zusammenfassend dargestellt, während die Stadtmauerbefunde von bisher nur überblicksartig veröffentlichten Fundstellen ausführlich dokumentiert werden.
Der zweite Teil beinhaltet die Diskussion der Ergebnisse geologischer Studien an grossen Abschnitten der Burkhardschen und der Inneren Stadtmauer.
Trends and correlates of girl-child marriage in 11 West African countries: evidence from recent Demographic and Health Surveys
Authors: Fatusi Adesegun O. , Adedini Sunday A. , Mobolaji Jacob Wale 
Published: June 2021

Background: West Africa historically has a high prevalence of girl-child marriage and requires substantial reduction to meet the United Nation’s Sustainable Development Goals (SDG) target of ending child marriage by 2030, but current data on progress is sparce. We aimed to determine the trend in child marriage in West Africa and assess the influence of selected socio-demographic factors. Methods: We analysed data on women aged 18-24 years from the two most recent Demographic and Health Surveys (conducted between 2006 and 2014) for 11 West African countries to determine the prevalence and trend of girl-child marriage. Multivariable logistic regression analysis was used to assess the relationship between girl-child marriage and selected socio-demographic factors. Results: The prevalence of child marriage in West Africa is 41.5%. An overall decrease of 4.6% (annual rate of 0.01%) was recorded over a seven-year inter-survey period. Three countries (Cote d’Ivoire, Nigeria, and Niger) recorded increased prevalence while the rate was unchanged in Burkina Faso, and the other six countries had reduced prevalence between the last two surveys. Sierra Leone recorded the highest decrease in prevalence (22%) and an annual reduction rate of 0.04%; Cote d’Ivore had the highest increase (65.3%). In virtually all countries, rural residence, low education, poor household economic status and non-Christian religious affiliation were significantly associated with higher odds of girl-child marriage. Conclusions: The prevalence of girl-child marriage remains high in West Africa and the trend shows very slow progress. While substantial inter-country variations exist in overall rate and trend of child marriage, the rate of progress is inadequate across all countries.
A study protocol of qualitative data sharing practices in clinical trials in the UK and Ireland: towards the production of good practice guidance
Authors: Houghton Catherine , McCarthy Megan , Gillies Katie , Rousseau Nikki , Wade Julia , Gamble Carrol , Toomey Elaine , Matvienko-Sikar Karen , Sydes Matthew , Dowling Maura , Bryant Val , Biesty Linda 
Published: June 2021

Background: Data sharing enables researchers to conduct novel research with previously collected data sets, thus maximising scientific findings and cost effectiveness, and reducing research waste. The value of sharing anonymised data from clinical trials is well recognised with a moderated access approach recommended. While substantial challenges to data sharing remain, there are additional challenges for qualitative data. Qualitative data including videos, interviews, and observations are often more readily identifiable than quantitative data. Existing guidance from UK Economic and Social Research Council applies to sharing qualitative data but does not address the additional challenges related to sharing qualitative data collected within trials, including the need to incorporate the necessary information and consent into already complex recruitment processes, with the additional sensitive nature of health-related data. Methods: Work package 1 will involve separate focus group interviews with members of each stakeholder group: trial managers, clinical trialists, qualitative researchers, members of research funding bodies and trial participants who have been involved in qualitative research. Data will be analysed using thematic analysis and managed within QSR NVivo to enhance transparency. Work package 2 will involve a documentary analysis of current consent procedures for qualitative data collected as part of the conduct of clinical trials. We will include documents such as participant information leaflets and consent forms for the qualitative components in trials. We will extract data such as whether specific clauses for data sharing are included in the consent form. Content analysis will be used to analyse whether and how consent is being obtained for qualitative data sharing. Conclusions: This study will provide insight into the existing practice of sharing of qualitative data in clinical trials and the current issues and opportunities, to help shape future research and development of guidance to encourage maximum learning to be gained from this valuable data.