bluuebunny/crossref_metadata_2025_split huggingface dataset:
Power flow management analysis using compensating techniques for managing congestion within electrical energy network
Authors: Jobanputra Jalpa , Kotwal Chetan 
Published: January 2021

AbstractIn a deregulated electrical energy system with increasing penetration of renewable energy sources, rescheduling of the power generation(s) is required, and it is going to congest some of the power lines in the complex power system. The power flow can be managed using different compensating techniques. This study presents power flow management analysis using selected compensation technologies (i.e. series, shunt, series-shunt, and D-FACTS) for congestion alleviation. In this work, an IEEE 6 bus distributed network is used and the mentioned compensating techniques are evaluated for congestion management considering a case of power line outage. It is observed some of the power lines are overloaded by 10%. To reduce the overloading; the series, shunt, series-shunt, D-FACTS compensation technologies are used and found that they can reduce the active power overloading of the congested line by 27%, 9.5%, 12%, and 27% respectively. But the apparent power congestions can be reduced using series and D-FACTS techniques by 14% compare to shunt and series-shunt techniques. It is affirmed that the D-FACTS can effectively manage the power flow compare to other compensation techniques and can offer other benefits (e.g. voltage quality, line power flows, injection of power at the buses, reduction in power losses, etc.).
Effect of the distance between primary pivots on the stability of two-chain cargo suspension arrangement
Authors: Nikitin Yevgeny V. , Podporin Sergei A. 
Published: January 2021

AbstractThe effect of distance between the primary pivots on stability of the two-chain suspension arrangement of a load has been explored. Based on the concept and methodology for calculating static stability, developed in previous works, it has been shown that the arrangement with narrow placement of the primary pivots is generally less stable than a normal arrangement. The reduced stability of such a system is primarily associated with a decrease in the length of the base of the stability triangle (ST) inside which the gravity center of the load (GCL) must be positioned. The minimal distance between primary pivots that provides equal stability to both arrangements (with narrow and normal primary pivots) has been also determined. An analytical inequality has been obtained, which allowed us to develop a decision rule to answer the question whether the stability of a system with narrow primary pivots is the same as that of a normal system. It has been shown that for the same geometric dimensions of both systems (with narrow and normal primary pivots) and the weight of the load, the fulfillment of the decisive inequality (rule) depends on the mass of the spreader. It has been shown that the stability of the system with wide position of the primary pivots is the same as for a normal system. Nevertheless, since the longer spreader is usually heavier than the normal one then the arrangement with wide primary pivots will be more stable than the normal arrangement.
Rapid and simultaneous purification of aflatoxin B1, zearalenone and deoxynivalenol using their monoclonal antibodies and magnetic nanoparticles
Authors: Lee Hyuk-Mi , Kang Hwan-Goo 
Published: January 2021

AbstractTo develop a new simple and simultaneous purification method for mycotoxins in feeds and grains, magnetic nanoparticles (MNPs) conjugated with monoclonal antibodies (mAbs) against mycotoxins were used to separate aflatoxin B1 (AFB1), zearalenone (ZEA) and deoxynivalenol (DON). For a single spike of each mycotoxin into the buffer solution (16% MeOH in PBS), mean recoveries were 93.1–95.0% for AFB1 (5–20 ng/mL spiked), 87.2–96.0% for ZEA (125–500 ng/mL spiked) and 75.2–96.9% for DON (250–1,000 ng/mL spiked) by HPLC and ELISA. Recoveries of AFB1 (20 ng/mL) and ZEA (500 ng/mL) simultaneously spiked into the buffer solution were 87.0 and 99.8%, respectively. Recovery rates of AFB1/DON and DON/ZEA spiked simultaneously were 86.2%/76.6% and 92.0%/86.7%, respectively, at concentrations of 20 ng/mL AFB1, 500 ng/mL ZEA, and 1,000 ng/mL DON. Recoveries using the novel mAb–MNP conjugated system in a buffer solution simultaneously spiked with AFB1, ZEA and DON were 82.5, 94.6 and 73.4%, respectively. Recoveries of DON in animal feed were 107.7–132.5% at concentrations of 250–1,000 ng/g spiked in feed. The immunoaffinity chromatography (IAC) clean-up method was compared with the purification method using novel mAb–MNP. After fortification of animal feed with AFB1 (5, 10 and 20 ng/g feed) and ZEA (125, 250 and 500 ng/g feed), AFB1 and ZEA were purified using both the methods. In the case of the novel mAb-MNP conjugated system, mean recoveries for AFB1 were 89.4, 73.1 and 88.3% at concentrations of 5, 10 and 20 ng/g feed, respectively. For ZEA, mean recoveries were 86.7, 85.9 and 79.1% at concentrations of 125, 250 and 500 ng/g, respectively. For IAC purification, recoveries were 42.9–45.1% for AFB1 and 96.8–103.2% for ZEA. In conclusion, the present purification method using monoclonal antibodies conjugated to MNPs can be used for simple and simultaneous purification of mycotoxins from feed and maize.
Deliberate hypotension as a mechanism to decrease intraoperative surgical site blood loss in resource limited setting: A systematic review and guideline
Authors: Tegegne Shimelis Seid , Gebregzi Amare Hailekiros , Arefayne Nurhussen Riskey 
Published: January 2021

ABSTRACT

Introduction:
Intraoperative surgical site bleeding is usually common in different types of surgeries. Even though there are different prevention techniques for intraoperative bleeding disorder, now adays deliberate hypotension is highly recommended as management options. Uncontrolled intraoperative bleeding may contribute to disability and even death. It can be the initial sign, and lead to incapacitating symptoms in patients undergoing moderate to major surgery.

Method:
Electronic search strategies used the following databases: Cochrane library, Pub Med, Medline and various internet search routines, for English publications. Key search terms included in our review are: Deliberate/controlled/induced/permissive hypotension, Intraoperative blood loss, Bleeding control, Intraoperative monitoring, Complication and anesthetic management. Availability of each referenced literature database was assessed until March 15–2019. References classified by evidence levels were selected by one individual and checked by another investigator.

Discussion:
Deliberate hypotension is listed as one of the blood conservation techniques to be considered with MAP between 50 and 65 mmHg and SBP between 80 and 90 mmHg with little to no reports of complication. A reduction of the patient's blood pressure improved the surgical field operating conditions. Resuscitation should be started after bleeding sites arrested. The most significant factor in deciding when to transfuse is based on one's attitude towards transfusion and the related ‘trigger’ criterion for transfusion.

Conclusion:
Hypotensive anesthesia protocol allowed perfect hemostasis control significantly with shorter operative time compared with other intraoperative controlling mechanisms for prevention of surgical site bleeding. The range of mean arterial pressure and blood pressure has to be closely monitored and any decrement from the expected range should be managed with vasoactive drugs.

Highlights
The link between fear about COVID-19 and insomnia: mediated by economic concerns and psychological distress, moderated by mindfulness
Authors: De Clercq Dirk , Haq Inam Ul , Azeem Muhammad Umer , Khalid Samia 
Published: January 2021

AbstractThis paper adds to extant research by examining the relationship between employees’ fear of coronavirus disease 2019 and their suffering from insomnia. It specifically proposes mediating roles of employees' economic concerns and psychological distress and a moderating role of mindfulness in this process. The research hypotheses are tested with survey data collected through two studies among Pakistani-based professionals: 316 in study 1 and 421 in study 2. The results pinpoint a salient risk for employees who experience fear during a pandemic crisis, in that the associated economic and psychological hardships make the situation worse by undermining their sleep quality, which eventually could diminish the quality of their lives even further. It also reveals how organizations can mitigate this risk if employees can leverage pertinent personal resources, such as mindfulness.
From Playground to Boardroom: Endowed Social Status and Managerial Performance
Authors: Du Fangfang 
Published: January 2021

AbstractUsing U.S. census survey data on CEOs’ residence in their formative years, I document a negative relation between CEOs’ endowed family wealth and managerial performance. Consistent with the view that CEOs born into low-income families face higher entry barriers but may possess greater levels of ability that enable them to become CEOs, I find that CEOs born into less privileged families outperform those from higher-wealth families. The outperformance of CEOs from less wealthy families is not driven by risk taking or omitted variables. Overall, my results suggest that CEOs’ social endowment provides a useful signal for their managerial ability.
A scoping review of the detection, epidemiology and control ofCyclospora cayetanensiswith an emphasis on produce, water and soil
Authors: Totton S. C. , O'Connor A. M. , Naganathan T. , Martinez B. A. F. , Vriezen E. R. , Torrence M. E. , Sargeant J. M. 
Published: January 2021

AbstractCyclospora cayetanensisis a parasite causing cyclosporiasis (an illness in humans). Produce (fruits, vegetables, herbs), water and soil contaminated withC. cayetanensishave been implicated in human infection. The objective was to conduct a scoping review of primary research in English on the detection, epidemiology and control ofC. cayetanensiswith an emphasis on produce, water and soil. MEDLINE® (Web of ScienceTM), Agricola (ProQuest), CABI Global Health, and Food Science and Technology Abstracts (EBSCOhost) were searched from 1979 to February 2020. Of the 349 relevant primary research studies identified, there were 75 detection-method studies, 40 molecular characterisation studies, 38 studies ofCyclosporain the environment (33 prevalence studies, 10 studies of factors associated with environmental contamination), 246 human infection studies (212 prevalence/incidence studies, 32 outbreak studies, 60 studies of environmental factors associated with non-outbreak human infection) and eight control studies. There appears to be sufficient literature for a systematic review of prevalence and factors associated with human infection withC. cayetanensis. There is a dearth of publicly available detection-method studies in soil (n= 0) and water (n= 2), prevalence studies on soil (n= 1) and studies of the control ofCyclospora(particularly on produce prior to retail (n= 0)).
Successful combination treatment with transcatheter balloon atrioseptostomy and bilateral pulmonary artery banding in a collapsed preterm neonate
Authors: Kuroda Hiroyuki , Nakano Yusuke , Machida Daisuke 
Published: January 2021

AbstractThere has been an increase in the use of extracorporeal membrane oxygenation for severe neonatal cardiac failure. However, the frequency of complications is high, particularly in preterm and low-birth-weight neonates. Herein, we present combination treatment with transcatheter balloon atrioseptostomy and bilateral pulmonary artery banding in a collapsed preterm neonate. This strategy can be an alternative to circulatory support using extracorporeal membrane oxygenation.
Coronary aneurysms, myocardial dysfunction, and shock in a COVID-19 child, role of ECMO, immunomodulation, and cardiac CT
Authors: Mustafa Muhammad R. , Carter Michael J. , Wong James , Bell Aaron , Salih Caner 
Published: January 2021

AbstractCoronary artery aneurysms in children were observed as a rare complication associated with coronavirus disease 2019 (COVID-19). This case report describes the severe end of the spectrum of the new multisystem inflammatory syndrome in a 12-year-old child with coronary aneurysms, myocardial dysfunction, and shock, managed successfully with extracorporeal membrane oxygenation support and immunomodulation therapy. This report also highlights the additional benefits of cardiac CT in the diagnosis and follow-up of coronary aneurysms.
Management of cognitive impairment in bipolar disorder: a systematic review of randomized controlled trials
Authors: Tamura Jocelyn K. , Carvalho Isabelle P. , Leanna Lui M. W. , Feng Jia Nuo , Rosenblat Joshua D. , Mansur Rodrigo , Lee Yena , Cha Danielle S. , Teopiz Kayla , Ahmad Zara , Nasri Flora , Kim Jiin , McIntyre Roger S. 
Published: January 2021

Abstract
Cognitive impairment is common in bipolar disorder and is emerging as a therapeutic target to enhance quality of life and function. A systematic search was conducted on PubMed, PsycInfo, Cochrane, clinicaltrials.gov, and Embase databases for blinded or open-label randomized controlled trials evaluating the pro-cognitive effects of pharmacological, neurostimulation, or psychological interventions for bipolar disorder. Twenty-two trials were identified, evaluating a total of 16 different pro-cognitive interventions. The methodological quality of the identified trials were assessed using the Cochrane Risk of Bias tool. Currently, no intervention (i.e., pharmacologic, neurostimulation, cognitive remediation) has demonstrated robust and independent pro-cognitive effects in adults with bipolar disorder. Findings are preliminary and methodological limitations limit the interpretation of results. Methodological considerations including, but not limited to, the enrichment with populations with pre-treatment cognitive impairment, as well as the inclusion of individuals who are in remission are encouraged. Future trials may also consider targeting interventions to specific cognitive subgroups and the use of biomarkers of cognitive function.
Development of an antimicrobial stewardship implementation model involving collaboration between general practitioners and pharmacists: GPPAS study in Australian primary care
Authors: Saha Sajal K. , Kong David C.M. , Thursky Karin , Mazza Danielle 
Published: January 2021

Abstract

Background:
Rising antimicrobial resistance (AMR) in primary care is a growing concern and a threat to community health. The rise of AMR can be slowed down if general practitioners (GPs) and community pharmacists (CPs) could work as a team to implement antimicrobial stewardship (AMS) programs for optimal use of antimicrobial(s). However, the evidence supporting a GP pharmacist collaborative AMS implementation model (GPPAS) in primary care remains limited.

Aim:
With an aim to design a GPPAS model in Australia, this paper outlines how this model will be developed.

Methods:
This exploratory study undertakes a systematic review, a scoping review, nationwide surveys, and qualitative interviews to design the model. Medical Research Council (MRC) framework and Normalization Process Theory are utilized as guides. Reviews will identify the list of effective GPPAS interventions. Two AMS surveys and paired interviews of GPs and CPs across Australia will explore their convergent and divergent views about the GPPAS interventions, attitudes towards collaboration in AMS and the perceived challenges of implementing GPPAS interventions. Systems Engineering Initiative for Patient Safety (SEIPS 2.0) model and factor analyses will guide the structure of GPPAS model through identifying the determinants of GPPAS uptake. The implementable GPPAS strategies will be selected based on empirical feasibility assessment by AMS stakeholders using the APEASE (Affordability, Practicability, Effectiveness and cost-effectiveness, Acceptability, Side-effects and safety, Equity) criteria.

Discussion:
The GPPAS model might have potential implications to inform how to better involve GPs and CPs in AMS, and, to improve collaborative services to optimize antimicrobial use and reduce AMR in primary care.
Dating the Northwest Shelf of Australia Since the Pliocene
Authors: Groeneveld J. , De Vleeschouwer D. , McCaffrey J. C. , Gallagher S. J. 
Published: January 2021

AbstractAccurate dating of marine sediments is essential to reconstruct past changes in oceanography and climate. Benthic foraminiferal oxygen isotope series from such sediments record long‐term changes in global ice volume and deep‐water temperature. They are commonly used in the Plio‐Pleistocene to correlate deep ocean records and to construct age models. However, continental margin settings often display much higher sedimentation rates due to variations in regional depositional setting and local input of sediment. Here, it is necessary to create a regional multi‐site framework to allow precise dating of strata. We create such a high‐resolution regional framework to determine the ages of events for the Northwest Shelf (NWS) of Australia, which was cored by International Ocean Discovery Program (IODP) Expedition 356. We employ benthic foraminiferal oxygen and carbon isotopes to construct an astronomically‐tuned age model for IODP Site U1463 (5.16–1.69 Ma). The age model is applied to the IODP Site U1463 downhole‐logging natural gamma radiation (NGR) depth‐series, which was then correlated to NGR depth‐series of several IODP sites and industry wells in the area. This approach allows assigning ages to regional seismic reflectors and the timing of key climate‐related siliciclastic phases in a predominantly carbonate‐rich sequence, like the late Miocene‐Pliocene Bare Formation. This age model is also used to chronologically calibrate planktonic foraminiferal biostratigraphic datums showing that the Indonesian Throughflow (ITF) had shoaled enough in the early Pliocene to act as biogeographical barrier between the Pacific and Indian Ocean.
Androgen receptor promotes renal cell carcinoma (RCC) vasculogenic mimicry (VM) via altering TWIST1 nonsense-mediated decay through lncRNA-TANAR
Authors: You Bosen , Sun Yin , Luo Jie , Wang Keliang , Liu Qing , Fang Ruizhe , Liu Bingmei , Chou Fuju , Wang Ronghao , Meng Jialin , Huang Chi-Ping , Yeh Shuyuan , Chang Chawnshang , Xu Wanhai 
Published: January 2021

AbstractWhile the androgen receptor (AR) may influence the progression of clear cell renal cell carcinoma (ccRCC), its role to impact vasculogenic mimicry (VM) to alter the ccRCC progression and metastasis remains obscure. Here, we demonstrated that elevated AR expression was positively correlated with tumor-originated vasculogenesis in ccRCC patients. Consistently, in vitro research revealed AR promoted VM formation in ccRCC cell lines via modulating lncRNA-TANAR/TWIST1 signals. Mechanism dissection showed that AR could increase lncRNA-TANAR (TANAR) expression through binding to the androgen response elements (AREs) located in its promoter region. Moreover, we found that TANAR could impede nonsense-mediated mRNA decay (NMD) of TWIST1 mRNA by direct interaction with TWIST1 5′UTR. A preclinical study using in vivo mouse model with orthotopic xenografts of ccRCC cells further confirmed the in vitro data. Together, these results illustrated that AR-mediated TANAR signals might play a crucial role in ccRCC VM formation and metastasis, and targeting this newly identified AR/TANAR/TWIST1 signaling may help in the development of a novel anti-angiogenesis therapy to better suppress the ccRCC progression.
Gene signature of children with severe respiratory syncytial virus infection
Authors: Dapat Clyde , Kumaki Satoru , Sakurai Hiroki , Nishimura Hidekazu , Labayo Hannah Karen Mina , Okamoto Michiko , Saito Mayuko , Oshitani Hitoshi 
Published: January 2021

AbstractBackgroundThe limited treatment options for children with severe respiratory syncytial virus (RSV) infection highlights the need for a comprehensive understanding of the host cellular response during infection. We aimed to identify host genes that are associated with severe RSV disease and to identify drugs that can be repurposed for the treatment of severe RSV infection.MethodsWe examined clinical data and blood samples from 37 hospitalized children (29 mild and 8 severe) with RSV infection. We tested RNA from blood samples using next-generation sequencing to profile global mRNA expression and identify cellular processes.ResultsRetractions, decreased breath sounds, and tachypnea were associated with disease severity. We observed upregulation of genes related to neutrophil, inflammatory response, blood coagulation, and downregulation of genes related to T cell response in children with severe RSV. Using network-based approach, 43 drugs were identified that are predicted to interact with the gene products of these differentially expressed genes.ConclusionsThese results suggest that the changes in the expression pattern in the innate and adaptive immune responses may be associated with RSV clinical severity. Compounds that target these cellular processes can be repositioned as candidate drugs in the treatment of severe RSV.ImpactNeutrophil, inflammation, and blood coagulation genes are upregulated in children with severe RSV infection.Expression of T cell response genes are suppressed in cases of severe RSV.Genes identified in this study can contribute in understanding the pathogenesis of RSV disease severity.Drugs that target cellular processes associated with severe RSV can be repositioned as potential therapeutic options.
The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis
Authors: Moujalled Diane , Gangatirkar Pradnya , Kauppi Maria , Corbin Jason , Lebois Marion , Murphy James M. , Lalaoui Najoua , Hildebrand Joanne M. , Silke John , Alexander Warren S. , Josefsson Emma C. 
Published: January 2021

AbstractNecroptosis is a pro-inflammatory cell death program executed by the terminal effector, mixed lineage kinase domain-like (MLKL). Previous studies suggested a role for the necroptotic machinery in platelets, where loss of MLKL or its upstream regulator, RIPK3 kinase, impacted thrombosis and haemostasis. However, it remains unknown whether necroptosis operates within megakaryocytes, the progenitors of platelets, and whether necroptotic cell death might contribute to or diminish platelet production. Here, we demonstrate that megakaryocytes possess a functional necroptosis signalling cascade. Necroptosis activation leads to phosphorylation of MLKL, loss of viability and cell swelling. Analyses at steady state and post antibody-mediated thrombocytopenia revealed that platelet production was normal in the absence of MLKL, however, platelet activation and haemostasis were impaired with prolonged tail re-bleeding times. We conclude that MLKL plays a role in regulating platelet function and haemostasis and that necroptosis signalling in megakaryocytes is dispensable for platelet production.