bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dancing Improves Emotional Regulation in Women With Methamphetamine Use Disorder But Use of a Cycle Ergometer Does Not
Authors: Tao Qian , Zhang Chenping , Li Xiawen 
Published: June 2021

BackgroundEmotional regulation is crucial to people who receive a diagnosis of methamphetamine (MA) use disorder. Although evidence that exercise improves emotional regulation is robust, little is known about whether exercise will improve emotional processing in women with MA use disorder.MethodsIn the present study, 36 women with MA use disorder aged 20 to 34 years and residing in the Drug Rehabilitation Bureau of Mogan Mountain in Zhejiang province were assigned to 1 of 2 exercise intervention groups-dancing or stationary cycling. Both types of exercise were performed at 65–75% of the maximum heart rate for 30 min. Immediately before and after the exercise bout, the participants were asked to score their feelings using a nine-point Likert scale as they viewed emotionally negative, positive, or neutral images in blocks of 20 images each, for a total of 60 images. Concurrent with viewing the images and self-rating their emotions, the women also underwent functional near-infrared spectroscopy to assess changes in brain activity.ResultsThere were no significant differences in the demographic or MA use characteristics assessed for the women between the two exercise groups. We found main effect of image valence (F2,33= 69.61,p&lt; 0.01), significant interaction effect of time and image valence was found (F2,33= 4.27,p&lt; 0.05) and trend increase in the self-rated emotional scale score for viewing negative images in both groups after 30-min exercise intervention, and the dancing group presented more significant trends than cycling group. In addition, activation in the dorsolateral prefrontal cortex of dancers, but not of cyclists, while viewing negative images was significantly lower after vs. before dancing (F2,33= 5.43,p&lt; 0.05). This result suggested that 30 min of dancing decreased neural activity in women with MA use disorder while they viewed negative images specifically in a brain region known to guide the selection of appropriate behaviors, and to shift attention.Taken together, the findings of this study suggest that for women with MA abuse disorder, 30 min of dancing, rather than of stationary cycling, may ameliorate negative emotional reactions by decreasing attention to negative stimuli.
Investigations on the Role of the MicroRNA-338-5p/Wnt Family Member 2B (WNT2B) Axis in Regulating the Pathogenesis of Nasopharyngeal Carcinoma (NPC)
Authors: Wang Suzhen , Yang Tianning , He Zhengxiang 
Published: June 2021

BackgroundThe involvement of microRNA-338-5p in modulating NPC pathogenesis is still largely unknown, and this study aimed to investigate this issue.MethodsThe expressions of cancer associated genes were determined by Real-Time qPCR and Western Blot, and cell apoptosis was determined by flow cytometer (FCM). CCK-8 assay and colony formation assay were respectively used to determine cell proliferation and colony formation abilities. Transwell assay was used to evaluate cell migration. The expression levels of Ki67 protein in mice tissues were measured by Immunohistochemistry (IHC) assay.ResultsThe present study found that microRNA-338-5p suppressed NPC progression by degrading its downstream target, Wnt family member 2B (WNT2B). Specifically, microRNA-338-5p tended to be low-expressed in NPC tissues and cell lines, compared to the non-tumor nasopharyngeal mucosa tissues and normal nasopharyngeal cell line (NP69). Upregulation of microRNA-338-5p inhibited proliferation, mobility, and epithelial-mesenchymal transition (EMT) in NPC cells in vitro, while silencing of microRNA-338-5p had opposite effects. Consistently, microRNA-338-5p suppressed tumorigenesis of NPC cells in vivo. In addition, microRNA-338-5p targeted WNT2B for degradation and inhibition, and the inhibiting effects of microRNA-338-5p overexpression on NPC development were reversed by upregulating WNT2B.ConclusionsTaken together, we concluded that microRNA-338-5p targeted WNT2B to hinder NPC development.
Inhaled Corticosteroids and the Pneumonia Risk in Patients With Chronic Obstructive Pulmonary Disease: A Meta-analysis of Randomized Controlled Trials
Authors: Chen Hong , Sun Jian , Huang Qiang , Liu Yongqi , Yuan Mengxin , Ma Chunlan , Yan Hao 
Published: June 2021

Background: Whether all types of inhaled corticosteroids (ICSs) would increase the pneumonia risk in patients with chronic obstructive pulmonary disease (COPD) remains controversial. We aimed to assess the association between ICSs treatment and pneumonia risk in COPD patients, and the impact of medication details and baseline characteristics of patients on the association.Methods: Four databases (PubMed, Embase, Cochrane Library, and Clinical Trials.gov) were searched to identify eligible randomized controlled trials (RCTs) comparing ICSs treatment with non-ICSs treatment on the pneumonia risk in COPD patients. Pooled results were calculated using Peto odds ratios (Peto ORs) with corresponding 95% confidence intervals (CIs).Results: A total of 59 RCTs enrolling 103,477 patients were analyzed. All types of ICSs significantly increased the pneumonia risk (Peto OR, 1.43; 95% CI, 1.34–1.53). Subgroup analysis showed that there was a dose-response relationship between ICSs treatment and pneumonia risk (low-dose: Peto OR, 1.33; 95% CI, 1.22–1.45; medium-dose: Peto OR, 1.50; 95% CI, 1.28–1.76; and high-dose: Peto OR, 1.64; 95% CI, 1.45–1.85). Subgroup analyses based on treatment durations and baseline characteristics (severity, age, and body mass index) of patients were consistant with the above results. Subgroup analysis based on severity of pneumonia showed that fluticasone (Peto OR, 1.75; 95% CI, 1.44–2.14) increased the risk of serious pneumonia, while budesonide and beclomethasone did not.Conclusions: ICSs treatment significantly increased the risk of pneumonia in COPD patients. There was a dose-response relationship between ICSs treatment and pneumonia risk. The pneumonia risk was related with COPD severity.
Tai Chi Chuan Alters Brain Functional Network Plasticity and Promotes Cognitive Flexibility
Authors: Cui Lei , Tao Sha , Yin Heng-chan , Shen Qi-qi , Wang Yuan , Zhu Li-na , Li Xiu-juan 
Published: June 2021

Objective: This study used resting-state functional magnetic resonance imaging to investigate the effects of 8 weeks of Tai Chi Chuan and general aerobic exercise on the topological parameters of brain functional networks, explored the advantages of Tai Chi Chuan for improving functional network plasticity and cognitive flexibility, and examined how changes in topological attributes of brain functional networks relate to cognitive flexibility.Methods: Thirty-six healthy adults were grouped into Tai Chi Chuan (Bafa Wubu of Tai Chi), general aerobic exercise (brisk walking), and control groups. All of the subjects underwent fMRI and behavioral assessment before and after the exercise intervention.Results: Tai Chi Chuan exercise significantly enhanced the clustering coefficient and local efficiency compared with general aerobic exercise. Regarding the nodal properties, Tai Chi Chuan significantly enhanced the nodal clustering coefficient of the bilateral olfactory cortex and left thalamus, significantly reduced the nodal clustering coefficient of the left inferior temporal gyrus, significantly improved the nodal efficiency of the right precuneus and bilateral posterior cingulate gyrus, and significantly improved the nodal local efficiency of the left thalamus and right olfactory cortex. Furthermore, the behavioral performance results demonstrated that cognitive flexibility was enhanced by Tai Chi Chuan. The change in the nodal clustering coefficient in the left thalamus induced by Tai Chi Chuan was a significant predictor of cognitive flexibility.Conclusion: These findings demonstrated that Tai Chi Chuan could promote brain functional specialization. Brain functional specialization enhanced by Tai Chi Chuan exercise was a predictor of greater cognitive flexibility.
Alexithymia Is Associated With Deficits in Visual Search for Emotional Faces in Clinical Depression
Authors: Suslow Thomas , Günther Vivien , Hensch Tilman , Kersting Anette , Bodenschatz Charlott Maria 
Published: June 2021

Background: The concept of alexithymia is characterized by difficulties identifying and describing one's emotions. Alexithymic individuals are impaired in the recognition of others' emotional facial expressions. Alexithymia is quite common in patients suffering from major depressive disorder. The face-in-the-crowd task is a visual search paradigm that assesses processing of multiple facial emotions. In the present eye-tracking study, the relationship between alexithymia and visual processing of facial emotions was examined in clinical depression.Materials and Methods: Gaze behavior and manual response times of 20 alexithymic and 19 non-alexithymic depressed patients were compared in a face-in-the-crowd task. Alexithymia was empirically measured via the 20-item Toronto Alexithymia-Scale. Angry, happy, and neutral facial expressions of different individuals were shown as target and distractor stimuli. Our analyses of gaze behavior focused on latency to the target face, number of distractor faces fixated before fixating the target, number of target fixations, and number of distractor faces fixated after fixating the target.Results: Alexithymic patients exhibited in general slower decision latencies compared to non-alexithymic patients in the face-in-the-crowd task. Patient groups did not differ in latency to target, number of target fixations, and number of distractors fixated prior to target fixation. However, after having looked at the target, alexithymic patients fixated more distractors than non-alexithymic patients, regardless of expression condition.Discussion: According to our results, alexithymia goes along with impairments in visual processing of multiple facial emotions in clinical depression. Alexithymia appears to be associated with delayed manual reaction times and prolonged scanning after the first target fixation in depression, but it might have no impact on the early search phase. The observed deficits could indicate difficulties in target identification and/or decision-making when processing multiple emotional facial expressions. Impairments of alexithymic depressed patients in processing emotions in crowds of faces seem not limited to a specific affective valence. In group situations, alexithymic depressed patients might be slowed in processing interindividual differences in emotional expressions compared with non-alexithymic depressed patients. This could represent a disadvantage in understanding non-verbal communication in groups.
Prospective Newborn Screening for Sickle Cell Disease and Other Inherited Blood Disorders in Central Malawi
Authors: Tegha Gerald , Topazian Hillary M. , Kamthunzi Portia , Howard Thad , Tembo Zondwayo , Mvalo Tisungane , Chome Nelecy , Kumwenda Wiza , Mkochi Tawonga , Hernandez Arielle , Ataga Kenneth I. , Hoffman Irving F. , Ware Russell E. 
Published: June 2021

Objectives: Newborn screening in the United States and Europe allows early identification of congenital disorders but does not yet exist in most low-resource settings, especially in sub-Saharan Africa. Newborn screening can identify multiple inherited hematological disorders, but feasibility and effectiveness for Africa are not fully determined.Methods: Surplus dried blood spot collected in Central Malawi through the HIV Early Infant Diagnosis surveillance program were repurposed and tested by isoelectric focusing for sickle cell disease and trait. Additional genetic testing identified G6PD deficiency and alpha thalassemia.Results: Testing of 10,529 cards revealed an overall sickle cell trait prevalence of 7.0% (range 3.9–9.7% by district); 10 of 14 infants identified with sickle cell disease (prevalence 0.1%) were located and received care at a specialized clinic. Subsequent testing of 1,329 randomly selected cards identified alpha thalassemia trait in 45.7% of samples, and G6PD deficiency in 20.4% of males and 3.4% of females, with 29.0% of females as heterozygous carriers.Conclusion: Inherited hematological disorders are common in Central Malawi; early identification through newborn screening can improve clinical outcomes and should be supported throughout Africa.
Ochraceopyronide, a Rare α-Pyrone-C-lyxofuranoside from a Soil-Derived Fungus Aspergillus ochraceopetaliformis
Authors: Asmaey Mostafa A. , Abatis Dennis , Abdel-Razek Ahmed S. , Lambrinidis George , Chinou Ioanna , Fokialakis Nikolas , Tsafantakis Nikolaos , Shaaban Mohamed , Aligiannis Nektarios 
Published: June 2021

The fungal strain was isolated from a soil sample collected in Giza province, Egypt, and was identified as Aspergillus ochraceopetaliformis based on phenotypic and genotypic data. The ethyl acetate extract of the fungal strain exhibited promising activity levels against several pathogenic test organisms and through a series of 1H NMR guided chromatographic separations, a new α-pyrone-C-lyxofuranoside (1) along with four known compounds (2–5) were isolated. The planar structure of the new metabolite was elucidated by detailed analysis of its 1D/2D NMR and HRMS/IR/UV spectroscopic data, while the relative configuration of the sugar moiety was determined by a combined study of NOESY and coupling constants data, with the aid of theoretical calculations. The structures of the known compounds—isolated for the first time from A. ochraceopetaliformis—were established by comparison of their spectroscopic data with those in the literature. All isolated fungal metabolites were evaluated for their antibacterial and antifungal activities against six Gram-positive and Gram-negative bacteria as well as against three human pathogenic fungi.
POLYMORPHISM OF BETA-CASEIN GENE IN THE KHOLMOGOR CATTLE BREED
Authors: КАЛАШНИКОВА Л.А. , ПРОЖЕРИН В.П. , ХАБИБРАХМАНОВА Я.А. , ПАВЛОВА И.Ю. , ГАНЧЕНКОВА Т.Б. , ЯЛУГА В.Л. 
Published: June 2021

Исследован полиморфизм гена β-казеина (CSN2) у холмогорской породы крупного рогатого скота (169 коров, 101 бык) из хозяйств Архангельской области и Республики Коми. Анализ ДНК проводили методом ПЦР с искусственно созданным сайтом рестрикции (ACRS). В стадах холмогорского скота Республики Коми частота аллеля А2 варьировала от 0,412 до 0,599, в целом преобладал аллель А2 гена β-казеина с частотой 0,557. Половина животных (49%) имела гетерозиготный генотип, 20% — обладали гомозиготным генотипом А1А1 и 31% — являлись гомозиготными по аллелю А2 β-казеина. В стадах холмогорского скота Архангельской области частота аллеля А2 была в целом ниже, чем в Республике Коми (0,466). Чаще встречался аллель А1 β-казеина (0,534). Большинство особей (45%) имели гетерозиготный генотип, 31% животных имели гомозиготный генотип А1А1 и 24% — А2А2. Показатель частоты встречаемости аллеля А2 в различных стадах Архангельской области отличался высокой степенью вариабельности от 0,238 до 0,692. Анализ полученных данных свидетельствует о том, что частота встречаемости аллелей и генотипов β-казеина в значительной степени зависит от особенностей ведения селекционно-племенной работы в хозяйстве.
The polymorphism of the beta-casein (CSN2) gene was studied in the Kholmogor breed of cattle (169 cows, 101 bulls) from the farms of the Arkhangelsk region and the Komi Republic. DNA analysis was performed by PCR with an artificially created restriction site (ACRS). In the herds of Kholmogor cattle of the Komi Republic, the frequency of the A2 allele varied from 0.412 to 0.599, in general, the A2 allele of the β-casein gene prevailed with a frequency of 0.557. Half of the animals (49%) had a heterozygous genotype, 20% had a homozygous A1A1 genotype, and 31% were homozygous for the A2 β-casein allele. In the herds of Kholmogor cattle of the Arkhangelsk region, the frequency of the A2 allele was generally lower than in the Komi Republic (0.466). The A1 allele of β-casein was more common (0.534). The majority of individuals (45%) had a heterozygous genotype, 31% of animals had a homozygous genotype A1A1 and 24% — A2A2. The frequency of occurrence of the A2 allele in various herds of the Arkhangelsk region was characterized by a high degree of variability from 0.238 to 0.692. The analysis of the obtained data shows that the frequency of occurrence of alleles and genotypes of β-casein largely depends on the peculiarities of conducting breeding work on the farm.
Stravinsky's Music Library in the Context of His Biography and Work (Based on Archival Materials From PauL Sacher Foundation)
Authors: Баранова-Монигетти Татьяна 
Published: June 2021

В статье представлены результаты исследования нотной коллекции из личной библиотеки И. Ф. Стравинского, хранящейся в Фонде Пауля Захера (Базель). Собрание это представляет особый интерес как творческая лаборатория Стравинского - композитора, пианиста, дирижера. Многие экземпляры содержат дарственные надписи и пометки на полях. Издания произведений самого Стравинского с корректурами и примечаниями автора дают ценную информацию об особенностях его композиционного процесса. Нотные источники рассмотрены в статье в контексте биографии и творчества композитора, с привлечением сведений из мемуаров, корреспонденции, музыковедческой литературы. Разделы статьи отражают структуру собрания.
This article presents the results of a study of the music score collection from Stravinsky's personal library, which is kept at the Paul Sacher Foundation in Basel. This collection is of particular interest as the creative laboratory of Stravinsky-a composer, pianist, conductor. Many copies have dedications, inscriptions and marginalia. The scores of Stravinsky's own works, with corrections and notes by the author, provide important information about his compositional process. Music scores from Stravinsky's library are considered in the context of his biography and work, using information from correspondence, memoirs and secondary literature. The sections of the article reflect the specifics of Stravinsky's collection.
ANALISA EFISIENSI BIAYA PEMBERIAN TEPUNG BAWANG PUTIH TERHADAP PERFORMA BURUNG PUYUH PADA FASE LAYER
Authors: Nur Wahyudi Ahmad Husaifi , Ghozali Ahmad Rofiq , Moes Edya Moelya 
Published: June 2021

This aims of the study is to analysed the effects of addition garlic powder in diet of quail. Data experiment were held on 1 th August – 15 th September 2017 at Ghozali Farm, Nglegok subdistric, Blitar regency. Two hunbred fourty quail age 6 to 7 months were used in this study. A randomized completely design was applied with 4 treatments and 5 replications. The treatment consists of P0: controls, P1: 0,2% addition garlic powder, P2: 0,4% addition garlic powder and P3: 0,6% addition garlic powder.The variance observed IOFC. The conclusion based on the result were : the treatment significant on IOFC and Return Cost Ratio. Its suggested to use 0,2% addition of garlic powder on quail ration.
ANALISIS REPRODUKSI KELINCI PERSILANGAN NEW ZEALAND WHITE DI KABUPATEN BLITAR
Authors: Rahayu Putri , Widyasworo Agustina , Ari kustanti Nita opi 
Published: June 2021

This research was conducted with the aim of knowing the reproduction of rabbit crosses in Blitar. The method used analysis quantitative descriptive the purpose is to describe the file. The research describe,deviation standart, highest and lowelst values. This research material uses rabbit crosses with the same maintenance and feeding systems that have at least given birth to litter size, service per conception, and birth interval.
The results obtained from this study to show an average litter size of 6 owned, service per conception of 2 times marriage and birth interval 2 months.
ANALISIS REPRODUKSI KELINCI PERSILANGAN NEW ZEALAND WHITE DI KABUPATEN BLITAR
Authors: Nianto Zida Trisna , Moeis Edya Moelia , Widyasworo Agustina 
Published: June 2021

This research was conducted at UD. Sultoni partner farms in Blitar district. The purpose of this study was to determine factors that could support mastitis in UD. Sultoni partners. This research is expected to be an input for farmers to overcome mastitis. The research material uses UD. Sultoni partner dairy cows with a total of 64 eco-lactation dairy cows from partner farmes UD. Sultoni. The method used in this study is a survey through gathering interview information and observations from a sample. The results of this study indicate that there is a influence on the variables of milk production, age of cattle, floor cleanliness, and dipping on mastitis. Whereas the lactation month shows a positive influence of mastitis.
PERBEDAAN PEMBERIAN ONGGOK TERFERMENTASI Trichoderma viride TERHADAP PENAMPILAN PRODUKSI AYAM KAMPUNG SUPER (Gallus domesticus sp)
Authors: Ajibah Binti Nur , Winurdana Alfan Setya , Sudani Eddy Trijana 
Published: June 2021

This research was aimed to determine different use tapioca by product fermentated with Trichoderma viride of Super Native Chicken production which includes Feed Covertion Ratio and Indeks Performance. In this research, used 120 super-native chickens aged 28 days. The method is an experimental with observation techniques. The design used was a Completely Randomized Design (CRD) consisting of 4 treatments and 6 replications. The treatment used in this study P0 (treatment without the addition of tapioca by product fermentated), P1 (treatment with addition of 25% of tapioca by product fermentated), P2 (treatment with addition of 50% of tapioca by product fermentated), P3 (treatment with addition of 75% of tapioca by product fermentated. The results of the research data show that the use of tapioca by product fermentated in Super Native Chicken rations did not have a significant effect (P >0.05) on the Feed Convertion Ratio and Indeks Performance. On the Feed Convertation Ratio with the lowest value in the treatment P0 of 4.17 gr/bird and on the Indeks Performance with the highest value in the treatment P1 of 60.85. The conclusion of this study is the use of tapioca by product fermentated can be given up to 25% in the feed as a substitute
Un día con más de 24 horas. Temporalidades histórico-literarias en una jornada de marzo de 1976
Authors: Fonsalido María Elena 
Published: June 2021

El trabajo propone, a partir del concepto de distanciamento de Ricardo Piglia para las narraciones del siglo XXI, y de las nociones benjaminianas de tiempo-ahora, constelación saturada de tensiones y pasaje de cepillo a contrapelo de la historia, indagar en los relatos que rememoran el 24 de marzo de 1976. Para ello se basa en tres textos publicados en Golpes. Relatos y memorias de la dictadura, libro editado por Miguel Dalmaroni y Victoria Torres a 40 años del golpe de estado argentino, que evocan “el trauma colectivo que nunca más dejará de interpelarnos” desde la perspectiva de escritores argentinos nacidos entre 1957 y 1973.
La enseñanza por pares, una estrategia didáctica para el aprendizaje de la electrocardiografía básica
Authors: Méndez Velásquez Juan Carlos , Pérez Giraldo Jaime Alberto 
Published: June 2021

La enseñanza de la electrocardiografía es un área de gran importancia en la formación de los estudiantes de pregrado, para los docentes es una preocupación constante que los médicos en formación adquieran las competencias para la lectura e interpretación del electrocardiograma (ECG). El presente estudio describe e indaga sobre cómo la estrategia didáctica de la enseñanza por pares mejora los procesos de aprendizaje de los estudiantes de segundo año de formación médica. Se halló evidencia de que la enseñanza por pares favorece el aprendizaje significativo de la fisiología cardiaca y del electrocardiograma, en particular; porque permite la adquisición de habilidades y destrezas a los estudiantes en la lectura del ECG y mejora la comprensión e interpretación de dicho examen; además, propicia relaciones horizontales entre pares que facilitan el desarrollo de la autonomía, el autoaprendizaje y el trabajo en equipo.