bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diversity of nematodes on banana (Musa spp.) in Kenya linked to altitude and with a focus on the pathogenicity of Pratylenchus goodeyi
Authors: Nyang’au Douglas , Atandi Janet , Cortada Laura , Nchore Shem , Mwangi Maina , Coyne Danny 
Published: October 2021

Summary
Bananas (Musa spp.) are considered the most important fruit crop in Kenya, grown mostly by smallholder farmers. However, in the past two decades production has declined and has largely been attributed to plant pathogens, including plant-parasitic nematodes. To assess the understanding and awareness that banana farmers have of nematodes, a survey was conducted. The incidence, abundance and distribution of nematodes in relation to altitude were determined for different banana types on 180 farms and the pathogenicity of Pratylenchus goodeyi, originating from three different altitudinal locations, was compared on two banana cultivars. Just 2.3% of farmers were aware of nematode damage and symptoms, none of whom applied any management measures. The highest abundance of nematodes was recorded at an altitude range of 1601-2000 m a.s.l., with Pratylenchus, Meloidogyne and Helicotylenchus being the predominant genera. Across all altitudinal locations, cooking banana had higher densities of nematodes than dessert bananas. In pots, P. goodeyi populations from Embu (1300 m a.s.l.) appeared more aggressive and with higher levels of multiplication than the population from Oyugis (1100 m a.s.l.). Cooking banana (‘Ng’ombe’) was more susceptible than dessert banana (‘Sukari Ndizi’). Nematode damage is more prominent in areas at higher altitude and on cooking banana cultivars. The findings provide key information in guiding informed and suitable management decision thresholds in relation to potential climate change.
Description of Ruehmaphelenchus taedae n. sp. (Nematoda: Aphelenchoididae) found in Loblolly pine logs from the USA
Authors: Gu Jianfeng , Fang Yiwu , Ma Xinxin , Lü Xiaoling , Chen Xianfeng 
Published: October 2021

Summary
Ruehmaphelenchus taedae n. sp., isolated from Loblolly pine logs (Pinus taedae L.) from the USA, is described and figured. It is characterised by a relatively slim body (a = 42 and 43 for males and females, respectively), three lines in the lateral field, male spicules relatively small (12-18 μm) with high and dorsally bent condylus and weakly developed rostrum, bursal flap absent, short tail possessing a long terminal spike ending in a bluntly rounded tip and 8.7-13.3 μm long, vulva positioned at ca 83% of body length, vulval flap absent, vulval lips slightly protruding, post-vulval uterine branch extending for less than half of vulva to anus distance, and female tail conoid, ca 3-4 anal body diam. long, with 13.7-18.5 μm terminal projection. The new species can be separated from all other species of the genus by the male tail possessing a long terminal spike and the more anterior excretory pore. Detailed phylogenetic analysis based on 28S D2-D3 region sequences confirmed the status of this nematode as a new species.
Potential Role of Yoga in the Management of Ankylosing Spondylitis: A Retrospective Study
Authors: Singh Jyoti , Tekur Padmini , Metri Kashinath G. , Mohanty Sriloy , Singh Amit , Nagaratna Raghuram 
Published: October 2021

Background: Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory spondyloarthropathy with unclear pathogenesis. The inflammatory pain in AS leads to restricted spinal mobility and significant disability. Yoga is a nonpharmacological intervention that has positive effects on various musculoskeletal-related problems. However, its role in AS is unknown. Objective: The present retrospective study assessed the efficacy of a two-week residential yoga intervention on spinal flexibility among AS patients. Methods: The records for 24 male AS patients within the age range 30 to 50 years (average age 38.3 ± 10.5 years) who underwent a two-week residential yoga retreat between 2015 and 2020 were obtained from a yoga center located in South India. Yoga intervention consisted of yoga postures, breathing practices, meditation, a healthy diet, and devotional sessions. Pre and Post data of the sit-and-reach test, blood pressure, heart rate, and symptom score were analyzed using Statistical Package for Social Sciences (SPSS). Results: Compared to the baseline, the post scores of the sit-and-reach test, systolic blood pressure and heart rate were found to be significantly ( P < .05) lower. The symptom score and analgesic medication score also showed significant improvement after two-weeks compared to the baseline. Conclusion: This retrospective study indicates the positive impact of on and analgesic use among AS patients. However, additional studies using robust research designs are warranted.
DMSO Delays Alzheimer Disease Causing Aβ-induced Paralysis in C. elegans Through Modulation of Glutamate/Acetylcholine Neurotransmission
Authors: Sadananda Girish , Velmurugan Janaki Devi , Subramaniam Jamuna R. 
Published: October 2021

Background: Alzheimer’s disease (AD), a prevalent neurodegenerative disease with progressive dementia and neurotransmission (NT)-dysfunction-related complications in older adults, is known to be caused by abnormal Amyloid-β (Aβ) peptide and associated amyloid plaques in the brain. Drugs to cure AD are not in sight. Two major excitatory neurotransmitters, glutamate (Glu) and acetylcholine (ACh), and their signaling systems are implicated in AD. Objective: To determine the effect of various NT-altering compounds including fenobam, quisqualic acid, and dimethyl sulfoxide (DMSO) in the protection against Aβ toxicity. Further, to identify the potential mechanism through which the protection happens. Methods: The well-known C. elegans AD model, CL4176, in which human Aβ expression is turned on upon a temperature shift to 25 °C that leads to paralysis, was screened for protection/delay in paralysis because of Αβ toxicity. While screening the compounds, dimethyl sulfoxide (DMSO), a universal solvent used to solubilize compounds, was identified to provide protection. Aldicarb and levamisole assays were performed to identify the contribution of ACh neurotransmission in Αβ toxicity protection by DMSO. Results: One percent and two percent DMSO delayed paralysis by 48% and 90%, respectively. DMSO was dominant over one of the Glu-NT pathway-related compounds, Fenobam-Group I mGluR antagonist. But DMSO provided only 30% to 50% protection against Quisqualic acid, the Glu-agonist. DMSO (2%) delayed ACh-NT, both presynaptic acetylcholine esterase inhibitor (AchEi)-aldicarb and postsynaptic-iAChR-agonst-levamisole induced paralysis, by ∼70% in CL4176. DMSO seems to be altering Ca2+ ion permeability essential for NT as EthyleneDiamine Tetra-Acetic acid (EDTA) and DMSO provided similar aldicarb resistance either combined or alone in wildtype worms. But postsynaptic Ca2+ depletion by EDTA could reverse DMSO-induced levamisole hypersensitivity. Surprisingly, the absence of FOrkhead boXO (FOXO) transcription factor homolog, daf-16 (loss-of-function mutant), a critical transcription factor in the reduced IIS-mediated longevity in C. elegans, abolished DMSO-mediated AldR. Conclusion: DMSO and Fenobam protect against Aβ toxicity through modulation of NT.
Politicising digital labour through the politics of body
Authors: Kim Changwook , Lee Sangkyu 
Published: October 2021

AbstractBy analysing the recent emerging labour movement of Korean digital game workers, this article seeks to explore a relatively novel issue – the importance of a politics of body in digital labour. By employing Elaine Scarry’s concept of ‘language of agency’ and ‘analogical substantiation’, the article first investigates how digital game workers express their work experiences and their embodied pain by analysing the mechanism of ‘crunch’ practice. Second, by examining ‘karoshi (overwork to death)’ and a series of suicides of digital game workers in Korea, it seeks to explore the problem of death as the final form of bodily pain – focusing on how these death events led workers to develop new forms of politics and solidarity by organising labour unions. Finally, by analysing the newly established digital game worker unions’ opposition to the violation of worktime regulation as a ‘struggle for recognition’, this research illuminates how digital game workers not only acquire self-respect but also achieve social recognition for their bodies as working labour. By examining this labour union organisation practice in Korea, the study ultimately argues that recognising the politics of body in digital labour offers the possibility that an emerging social category of precariat can actually co-exist and connect with the existing social class of proletariat.
The Successful Vaccination of an IVIgG Naive CVID Patient with an mRNA COVID-19 Vaccine
Authors: Jalil Maaz , Abraham John M. , Hostoffer Robert 
Published: October 2021

Introduction Different subtypes of vaccines have been developed to help protect populations from COVID-19. Currently, three vaccines have been authorized by the United States Food and Drug Administration for emergency use to combat the COVID-19 pandemic. With COVID-19 vaccination rates increasing, it is important to know whether immunodeficient patients have the capacity to mount an immune response with the available vaccines. Case Report A 78-year-old female with Common Variable Immunodeficiency and anti-IgA antibodies who is naïve to IVIgG treatment responded positively to a COVID-19 mRNA vaccine. Successful seroconversion was proved by having positive COVID-19 spike protein IgG antibodies weeks after the vaccination. Her recent IgG, IgA, and IgM levels were all significantly reduced. Previously, she had no response to the polysaccharide pneumococcal vaccine, but did maintain titers afterTdap vaccination. Discussion Immunodeficient patients are a susceptible population during a pandemic. Unfortunately, there is a paucity of research on the infectivity, vaccination, and outcome of these patients during the COVID-19 outbreak. Our patient with CVID was able to respond to protein/toxoid vaccines, but did not respond to polysaccharide pneumococcal vaccine. After inoculation with an mRNA COVID-19 vaccine she was able to create COVID-19 spike protein IgG antibodies. Conclusion We present a case of successful vaccination to COVID-19 by an mRNA vaccine in an IVIgG naïve CVID patient.
Are We Transitioning Toward Person-centered Practice on Self-management Support? An Explorative Case Study Among Rheumatology Outpatient Clinic Nurses in Norway
Authors: Fischer Heike , Grønning Kjersti 
Published: October 2021

Introduction There are only a few studies investigating nurses’ views on self-management in the care of patients with rheumatic diseases. Objective The aim of this study is to explore how Norwegian rheumatology outpatient nurses describe their ways of supporting patients’ self-management focusing on the core dimensions of person-centered self-management support. Methods Ten individual semistructured interviews with rheumatology outpatient nurses were conducted in Norway from March to September 2017. The interviews were audiorecorded and transcribed verbatim. NVIVO was used to support a systematic analysis of themes and patterns. Results Nurses’ views on self-management support fell into three approaches; (1) narrowly biomedically orientated, (2) biomedically and holistic, and (3) person-centered. The nurse's views of self-management support varied and did not fully align with the core dimensions of person-centered practice. Conclusion The findings indicate that the biomedical paradigm continues to influence Norwegian rheumatology outpatient clinic nurses’ approach to self-management support. If person-centered principles of self-management support are to be translated into standard nursing practice, including identifying and supporting patient-defined self-management goals and processes, there is a need to challenge established structures in health care systems.
Unusual Findings in Trials Evaluating Adjuncts to Scaling and Root Planing: Reporting Quality (Part 2)
Authors: Al-Abedalla K. , Gunsolley J.C. , Shaqman M. , Ioannidou E. 
Published: October 2021

Introduction: On the topic of adjuncts to scaling and root planing (SRP), numerous randomized clinical trials (RCTs) were published by a single group of authors and frequently reported unusually large effect sizes. A meta-analysis in part 1 of this project failed to explain the causes for these unusual findings. We assessed the reporting quality and trial registration discrepancies to examine the possibility of replicating the work of this research group as well as the overall rigor of the research methodology. Methods: This study was preregistered at the Open Science Framework ( https://osf.io/4meyd/ ). The Scopus platform was utilized for the RCT search on SRP adjuncts in intrabony defects in patients with periodontitis as compared with SRP alone. The search analysis was limited from 2010 to 2017, and RCTs on SRP adjuncts published by a single research group were selected for screening and inclusion. RCT registration records were assessed for consistency. Results: Out of 92 studies that were retrieved from Scopus and PubMed, 32 were included for quality assessment per the CONSORT guidelines (Consolidated Standards of Reporting Trials). Results showed that all RCTs were characterized by a low reporting quality. The majority of CONSORT items scored <50%, including critical items (randomization, registration, and blinding). When registration records were compared with published RCTs, several discrepancies were found. The per-protocol follow-up duration was compared against the study’s initiation and termination dates. Only 38% of the RCTs presented a follow-up period within the initiation and termination dates. The remaining RCTs showed inconsistent follow-up in comparison with the initiation and termination dates. Conclusion: RCTs by this group were characterized by poor adherence to reporting quality guidelines. Crucial RCT elements, such as randomization, blinding, and primary outcomes, were not reported properly. RCT registration records revealed systematic inconsistencies when compared with RCT publication. Therefore, the unusually large effects reported by this group should be viewed with extreme caution. Knowledge Transfer Statement: The included randomized clinical trials were characterized by poor adherence to reporting quality guidelines, missing information about important trial items, and discrepancies between the reports and trial registrations. This quality assessment should guide clinical research and show clinicians that they should be cautious when applying evidence in their clinical practice.
Reflections on the Contemporary World Mission
Authors: Stockwell Eugene L. 
Published: October 2021

We come together today as a new Unit Committee of the Division of Overseas Ministries (DOM) at the beginning of the 1976–1978 triennium of the National Council of Churches. During this meeting, and in the months ahead, we will face important decisions which, given the magnitude of both the problems we confront and the resources we can tap, will be pressing and fateful. It would be foolish to exaggerate our role — there is very real sense in which our ecumenical vehicle is fragile and weak, far less influential on the world, national, ecclesiastical, scenes than we are prone to admit — but it would be folly as well to underrate the realistic and timely role we can assume in the exercise of the Christian stewardship expected of us in our day. Allow me to commence with a very personal recollection — perhaps unduly personal. Exactly fifty years ago this year – in 1926 — my father and mother sailed out of New York harbor bound for Buenos Aires, Argentina. I was three years old at the time and they took me along. They were setting out on an overseas ministry in the year of our nation's sesquicentennial though I doubt that they gave that fact much importance. I now look back on this ministry from the year of our nation's bicentennial and wonder at the immense changes in the context of mission and ministry between 1926 and 1976. My father was quite clear about one purpose in 1926, a clarity he never lost however unclear he might have felt in other areas of his work — he was determined to do what he could to train young men and women for the fulltime
Hematologic complications of immune checkpoint inhibitors
Authors: Kroll Michael H. , Rojas-Hernandez Cristhiam , Yee Cassian 
Published: October 2021

Abstract
Immune checkpoint inhibitors are a class of antineoplastic therapies that unleash immune cells to kill malignant cells. There are currently 7 medications that have been approved by the US Food and Drug Administration for the treatment of 14 solid tumors and 2 hematologic malignancies. These medications commonly cause immune-related adverse effects as a result of overactive T lymphocytes, autoantibody production, and/or cytokine dysregulation. Hematologic toxicities are rare and of uncertain mechanism, and therefore management is often based on experiences with familiar conditions involving these perturbed immune responses, such as autoimmune hemolytic anemia, immune thrombocytopenia, and idiopathic aplastic anemia. Management is challenging because one must attend to the hematologic toxicity while simultaneously attending to the malignancy, with the imperative that effective cancer therapy be maintained or minimally interrupted if possible. The purpose of this review is to help clinicians by providing a clinical and pathophysiological framework in which to view these problems.
Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth
Authors: Man Cheuk Him , Mercier Francois E. , Liu Nian , Dong Wentao , Stephanopoulos Gregory , Jiang Li , Jung Yookyung , Lin Charles P. , Leung Anskar Y. H. , Scadden David T. 
Published: October 2021

Abstract
Proton export is often considered a detoxifying process in animal cells, with monocarboxylate symporters coexporting excessive lactate and protons during glycolysis or the Warburg effect. We report a novel mechanism by which lactate/H+ export is sufficient to induce cell growth. Increased intracellular pH selectively activates catalysis by key metabolic gatekeeper enzymes HK1/PKM2/G6PDH, thereby enhancing glycolytic and pentose phosphate pathway carbon flux. The result is increased nucleotide levels, NADPH/NADP+ ratio, and cell proliferation. Simply increasing the lactate/proton symporter monocarboxylate transporter 4 (MCT4) or the sodium-proton antiporter NHE1 was sufficient to increase intracellular pH and give normal hematopoietic cells a significant competitive growth advantage in vivo. This process does not require additional cytokine triggers and is exploited in malignancy, where leukemogenic mutations epigenetically increase MCT4. Inhibiting MCT4 decreased intracellular pH and carbon flux and eliminated acute myeloid leukemia–initiating cells in mice without cytotoxic chemotherapy. Intracellular alkalization is a primitive mechanism by which proton partitioning can directly reprogram carbon metabolism for cell growth.
Targeting cholesterol homeostasis in hematopoietic malignancies
Authors: Brendolan Andrea , Russo Vincenzo 
Published: October 2021

Abstract
Cholesterol is a vital lipid for cellular functions. It is necessary for membrane biogenesis, cell proliferation, and differentiation. In addition to maintaining cell integrity and permeability, increasing evidence indicates a strict link between cholesterol homeostasis, inflammation, and hematological tumors. This makes cholesterol homeostasis an optimal therapeutic target for hematopoietic malignancies. Manipulating cholesterol homeostasis by either interfering with its synthesis or activating the reverse cholesterol transport via the engagement of liver X receptors affects the integrity of tumor cells both in vitro and in vivo. Cholesterol homeostasis has also been manipulated to restore antitumor immune responses in preclinical models. These observations have prompted clinical trials involving acute myeloid leukemia to test the combination of chemotherapy with drugs interfering with cholesterol synthesis (ie, statins). We review the role of cholesterol homeostasis in hematopoietic malignancies as well as in cells of the tumor microenvironment and discuss the potential use of lipid modulators for therapeutic purposes.
Acute kidney injury and COVID-19
Authors: Al-kuraishy Hayder M. , Al-Gareeb Ali I. 
Published: October 2021

AbstractBackgroundCoronavirus disease 2019 (COVID-19) is a recent pandemic infectious disease caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2). COVID-19 may lead to acute kidney injury (AKI).Main textSARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) and dipeptidyl peptidase 4(DPP4) as entry point receptors in the alveolar type II cell of the lung. However, the expression of ACE2 is 100-fold higher in kidney tissue than the lung, though the potential entry point of SARS-CoV-2 for renal tissue and induction of AKI remains undefined. Therefore, reduction of ACE2 and high circulating angiotensin II in COVID-19 may together participate in the induction of AKI. Thereby, direct ACE2 activator is under investigation to be used as an effective therapy in the management COVID-19-induced AKI. Besides, the direct effect via invasion of SARS-CoV-2 may lead to glomerulopathy and renal proximal tubular necrosis.ConclusionCOVID-19 may associate with AKI due to direct effect of SARS-CoV-2 through ACE2 and DPP4 receptors or indirectly through the development of cytokine storm. Both ACE2 and DPP4 are interacted mutually in the pathogenesis of AKI. Thus, DPP4 inhibitors or ACE2 activators could reverse early AKI in COVID-19. Therefore, emerging of clinical trials is warranted to confirm the role of ACE2 and DPP4 modulators in COVID-19-induced AKI.
Psychiatric disorders diagnosed in adolescence and subsequent long-term exclusion from education, employment or training: longitudinal national birth cohort study
Authors: Ringbom Ida , Suvisaari Jaana , Kääriälä Antti , Sourander Andre , Gissler Mika , Ristikari Tiina , Gyllenberg David 
Published: October 2021

BackgroundLong-term ‘not in education, employment or training’ (NEET) status is an important indicator of youth marginalisation.AimsTo carry out a comprehensive overview of the associations between different psychiatric illnesses and long-term NEET status.MethodWe used the register-based 1987 Finnish Birth Cohort study, which includes all live births in Finland during that year. The analyses comprised 55 273 individuals after exclusions for intellectual disability, death or emigration. We predicted that psychiatric disorders, diagnosed by specialist services between 1998 and 2007 when the cohort were 10–20 years of age, would be associated with subsequent long-term NEET (defined as NEET for at least 5 years between 2008 and 2015, when they were 20–28 years of age).ResultsIn total, 1438 individuals (2.6%) were long-term NEET during follow-up and the associations between long-term NEET and the 11 diagnostic categories we studied were statistically significant (P < 0.001). In multivariate models we included sociodemographic characteristics and upper secondary education as covariates, and the highest effect sizes, measured by odds ratios (OR) with 95% confidence intervals (CI), were found for psychosis (OR = 12.0, 95% CI 9.5–15.2) and autism spectrum disorder (OR = 17.3, 95% CI 11.5–26.0). If individuals had not successfully completed this education, 70.6% of those with autism spectrum disorder and 48.4% of those with psychosis were later long-term NEET.ConclusionsAdolescents who receive treatment for psychiatric disorders, particularly autism spectrum disorder or psychosis, need support to access education and employment. This could help to prevent marginalisation in early adulthood.