bluuebunny/crossref_metadata_2025_split huggingface dataset:
Essential oils of Bursera morelensis and Lippia graveolens for the development of a new biopesticides in postharvest control
Authors: Medina-Romero Yoli Mariana , Hernandez-Hernandez Ana Bertha , Rodriguez-Monroy Marco Aurelio , Canales-Martínez María Margarita 
Published: October 2021

AbstractFruit and vegetable crops that are not consumed immediately, unlike other agricultural products, require economic and time investments until they reach the final consumers. Synthetic agrochemicals are used to maintain and prolong the storage life of crops and avoid losses caused by phytopathogenic microorganisms. However, the excessive use of synthetic agrochemicals creates health problems and contributes to environmental pollution. To avoid these problems, less toxic and environment-friendly alternatives are sought. One of these alternatives is the application of biopesticides. However, few biopesticides are currently used. In this study, the biopesticide activity of Bursera morelensis and Lippia graveolens essential oils was evaluated. Their antifungal activity has been verified in an in vitro model, and chemical composition has been determined using gas chromatography-mass spectrometry. Their antifungal activity was corroborated in vitro, and their activity as biopesticides was subsequently evaluated in a plant model. In addition, the persistence of these essential oils on the surface of the plant model was determined. Results suggest that both essential oils are promising candidates for producing biopesticides. This is the first study showing that B. morelensis and L. graveolens essential oils work by inhibiting mycelial growth and spore germination and are environment-friendly biopesticides.
Immune pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma
Authors: Das Sunetra , Idate Rupa , Regan Daniel P. , Fowles Jared S. , Lana Susan E. , Thamm Douglas H. , Gustafson Daniel L. , Duval Dawn L. 
Published: October 2021

AbstractOsteosarcoma affects about 2.8% of dogs with cancer, with a one-year survival rate of approximately 45%. The purpose of this study was to characterize mutation and expression profiles of osteosarcoma and its association with outcome in dogs. The number of somatic variants identified across 26 samples ranged from 145 to 2,697 with top recurrent mutations observed in TP53 and SETD2. Additionally, 47 cancer genes were identified with copy number variations. Missense TP53 mutation status and low pre-treatment blood monocyte counts were associated with a longer disease-free interval (DFI). Patients with longer DFI also showed increased transcript levels of anti-tumor immune response genes. Although, T-cell and myeloid cell quantifications were not significantly associated with outcome; immune related genes, PDL-1 and CD160, were correlated with T-cell abundance. Overall, the association of gene expression and mutation profiles to outcome provides insights into pathogenesis and therapeutic interventions in osteosarcoma patients.
Emergent colloidal currents across ordered and disordered landscapes
Authors: Lips Dominik , Stoop Ralph L. , Maass Philipp , Tierno Pietro 
Published: October 2021

AbstractMany-particle effects in driven systems far from equilibrium lead to a rich variety of emergent phenomena. Their classification and understanding often require suitable model systems. Here we show that microscopic magnetic particles driven along ordered and defective lattices by a traveling wave potential display a nonlinear current-density relationship, which arises from the interplay of two effects. The first one originates from particle sizes nearly commensurate with the substrate in combination with attractive pair interactions. It governs the colloidal current at small densities and leads to a superlinear increase. We explain such effect by an exactly solvable model of constrained cluster dynamics. The second effect is interpreted to result from a defect-induced breakup of coherent cluster motion, leading to jamming at higher densities. Finally, we demonstrate that a lattice gas model with parallel update is able to capture the experimental findings for this complex many-body system.
Arbeiten zur falschen Zeit
Authors: Opalka Markus 
Published: October 2021

SummaryDie innere Uhr synchronisiert sich mit äußeren Gegebenheiten – insbesondere mit dem Tag-Nacht-Rhythmus – und steuert zahlreiche Prozesse im Organismus.Insbesondere durch Nachtschichten erfolgt eine Betätigung gegen die innere Uhr, was körperliche und psychische Konsequenzen nach sich ziehen kann. Wenn nächtliche Arbeit nicht beendet werden kann, können einige Maßnahmen den Rhythmuswechsel unterstützen, beispielsweise eine leichte Kost während der Nachtschicht.
Herz im Abschaltmodus
Authors: Jahn Claus 
Published: October 2021

SummaryEin 50-jähriger, sportlicher Patient entwickelt plötzlich bei jedem Training kardioforme Symptome wie Übelkeit, Schwindel und Atemnot. Nachdem die kardiologische Diagnostik außer einem sogenannten Sportlerherz keine Erklärung für die Symptome eröffnen konnte, liefert eine Smartwatch den entscheidenden Hinweis auf ein Sick-Sinus-Syndrom. Durch pulsbegrenztes Training und eine begleitende phytotherapeutische, segmentale und homöopathische Therapie gelingt eine deutliche Verbesserung bis hin zur Vermeidung der sinuatrialen Krisen.
Frühe Diagnostik und Therapie der Kleingefäßvaskulitiden
Authors: Kavruk Hilal , Baraliakos Xenofon 
Published: October 2021

ZUSAMMENFASSUNGDie Kleingefäßvaskulitiden als Untergruppe der Vaskulitiden stellen selbst auch ein Spektrum an verschiedenen Subentitäten dar, deren Diagnostik und Therapie teilweise fachübergreifend erfolgt. Man unterscheidet die ANCA-assoziierten von den Nicht-ANCA-assoziierten Vaskulitiden. Es handelt sich um die Granulomatose mit Polyangiitis, die mikroskopische Polyangiitis, die antiglomeruläre Basalmembran-Erkrankung, die kryoglobulinämische Vaskulitis, die IgA-Vaskulitis und die hypokomplementämische Urtikariavaskulitis. Epidemiologische Kennzahlen schwanken, nicht zuletzt aufgrund ihrer Seltenheit, allerdings konnten verbesserte diagnostische Möglichkeiten, erhöhtes Bewusstsein und vertiefte Kenntnis für diese Erkrankungen auch besser regionale und Altersunterschiede erkennbar machen. Eine breite Zahl an Organen kann betroffen sein, häufig liegt, je nach Subentität, eine Organprädilektion vor. Die Behandlung der Kleingefäßvaskulitiden orientiert sich an Schwere und Ausmaß der Krankheit und variiert zwischen den einzelnen Subentitäten. Hauptvertreter der medikamentösen Therapie sind Glukokortikoide, Rituximab und Cyclophosphamid.
Adäquate Versorgungsstrukturen und Bedeutung von Big-Data-Analysen bei EMAH-Patienten
Authors: Diller Gerhard-Paul , Baumgartner Helmut 
Published: October 2021

ZusammenfassungDa immer mehr Kinder mit angeborenem Herzfehler (AHF) überleben und ins Erwachsenenalter
eintreten, sind nunmehr rund zwei Drittel der aktuellen AHF-Patienten Erwachsene mit
angeborenen Herzfehlern (EMAH). Es wird geschätzt, dass in Deutschland aktuell ca. 350000
EMAH-Patienten leben, wobei die Zahl weiter rasch zunimmt. Die lebenslange kardiologische
Anbindung von EMAH-Patienten ist nach aktuellen Leitlinienempfehlungen erforderlich und mit
einer niedrigeren Letalität und Morbidität assoziiert. Somit ist die ausschließliche
hausärztliche Versorgung von EMAH-Patienten nicht ausreichend. EMAH-Patienten sind an
spezialisierte EMAH-Zentren/bei EMAH-Kardiologen anzubinden und sollten gemeinschaftlich mit
niedergelassenen kardiologischen Kollegen behandelt werden. Big Data und Methoden des
maschinellen Lernens sind integraler Bestandteil der Forschungsbemühungen bei EMAH-Patienten,
die unter einer chronischen, lebenslangen Erkrankung leiden. Methoden der künstlichen
Intelligenz werden die Versorgung von EMAH-Patienten in Zukunft effizienter machen und die
Reproduzierbarkeit von Bildgebungsuntersuchungen erhöhen.
Psychokardiologische Aspekte bei Erwachsenen mit angeborenem Herzfehler (EMAH)
Authors: Kahl Kai G. , Westhoff-Bleck Mechthild 
Published: October 2021

ZusammenfassungBedingt durch die verbesserte medizinische Versorgung von Patienten mit angeborenen
Herzfehlern und die damit einhergehende verlängerte Lebenserwartung treten
psychokardiologische Aspekte stärker in den Vordergrund. Hierzu zählen u. a. die Inzidenz
komorbider psychischer Störungen, Fragen nach den Faktoren, die eine optimale Lebensqualität
ermöglichen, den Einfluss eines angeborenen Herzfehlers auf Partnerschaft und Lebensgestaltung
sowie Lebensstilfaktoren und Adhärenz. In Zeiten knapper Personalressourcen und zunehmenden
ökonomischen Drucks ist darüber hinaus eine effektive Diagnostik psychosozialer Probleme und
ggf. Einleitung einer wirkungsvollen psychosozialen Therapie wichtig. Die interdisziplinäre
Zusammenarbeit unter Einbezug moderner psychokardiologischer Konzepte ist daher in der
langfristigen Therapie von EMAH-Patienten von entscheidender Bedeutung.
Relationship of Change in Cervical Curvature after Laminectomy with Lateral Mass Screw Fixation to Spinal Cord Shift and Clinical Efficacy
Authors: Hou Shu-bing , Sun Xian-ze , Liu Feng-yu , Gong Rui , Zhao Zheng-qi , Lu Kuan , Liu Yan-bing 
Published: October 2021

Abstract
Background and Study Aims Although laminectomy with lateral mass screw fixation (LCSF) is an effective surgical treatment for cervical spondylotic myelopathy (CSM), loss of cervical curvature may result. This study aimed to investigate the effect of cervical curvature on spinal cord drift distance and clinical efficacy.
Patients and Methods We retrospectively analyzed 78 consecutive CSM patients with normal cervical curvature who underwent LCSF. Cervical curvature was measured according to Borden's method 6 months after surgery. Study patients were divided into two groups: group A, reduced cervical curvature (cervical lordosis depth 0–7mm; n = 42); and group B, normal cervical curvature (cervical lordosis depth 7–17mm; n = 36). Spinal cord drift distance, laminectomy width, neurologic functional recovery, axial symptom (AS) severity, and incidence of C5 palsy were measured and compared.
Results Cervical lordosis depth was 5.1 ± 1.2 mm in group A and 12.3 ± 2.4 mm in group B (p < 0.05). Laminectomy width was 21.5 ± 2.6 mm in group A and 21.9 ± 2.8 mm in group B (p > 0.05). Spinal cord drift distance was significantly shorter in group A (1.9 ± 0.4 vs. 2.6 ± 0.7 mm; p < 0.05). The Japanese Orthopaedic Association (JOA) score significantly increased after surgery in both groups (p < 0.05). Neurologic recovery rate did not differ between the two groups (61.5 vs. 62.7%; p > 0.05). AS severity was significantly higher in group A (p < 0.05). C5 palsy occurred in three group A patients (7.1%) and four group B patients (11.1%), but the difference was not significant (p > 0.05).
Conclusion After LCSF, 53.8% of the patients developed loss of cervical curvature. A smaller cervical curvature resulted in a shorter spinal cord drift distance. Loss of cervical curvature was related to AS severity but not improvement of neurologic function or incidence of C5 palsy.
Cervical Single-Level Pincer Stenosis Causing Myelopathy: A Technical Note and Medium-term Results of a One-Session Microsurgical 360-Degree Treatment
Authors: Papavero Luca , Pietrek Markus , Marques Carlos J. , Schmeiser Gregor 
Published: October 2021

Abstract
Background and Study Aims Single-level circumferential or pincer stenosis (PS) affects few patients with degenerative cervical myelopathy (DCM). The surgical technique and medium-term results of a one-session microsurgical 360-degree (m360°) procedure are presented.
Patients Between 2013 and 2018, the data of 23 patients were prospectively collected out of 371 patients with DCM. The m360° procedure comprised a microsurgical anterior cervical decompression and fusion (ACDF), with additional plate fixation, followed by flipping the patient and performing a microsurgical posterior bilateral decompression via a unilateral approach in crossover technique.
Results The mean age of the patients was 72 years (range: 50–84); 17 patients were males. The mean follow-up time was 12 months (range: 6–31). The patients filled in the patient-derived modified Japanese Orthopaedic Association (P-mJOA) questionnaire on average 53 months after surgery. One patient received a two-level ACDF. Lesions were mostly (92%) located at the C3/C4 (8/24), C4/C5 (7/24), and C5/C6 (7/24) levels. Functional X-rays showed segmental instability in 10 of 23 patients (44%). All preoperative T2-weighted magnetic resonance imaging (MRI) showed an intramedullary hyperintensity. The median preoperative mJOA score was 13 (range 3), and it improved to 16 (range 3) postoperatively. The mean improvement rate in the mJOA score was 73%. When available, postoperative MRI confirmed good circumferential decompression with persistent intramedullary hyperintensity. There were two complications: a long-lasting radicular paresthesia at C6 and a transient C5 palsy. No revision surgery was required.
Conclusion The one-session m360° procedure was found to be a safe surgical procedure for the treatment of PS, and the medium-term clinical outcome was satisfactory.
Tibial Tuberosity Transposition Fixation with a Locking Plate during Medial Patellar Luxation Surgery: An Ex Vivo Mechanical Study
Authors: Eskelinen Esa V. , Suhonen Ari P. , Virolainen Juha V. , Liska William D. 
Published: October 2021

AbstractObjectives The purpose of this study was to compare the load at failure, stiffness and mode of failure between three types of tibial tuberosity transposition fixation techniques: (a) pin and figure-8 tension band wire (Pin-TBW), (b) locking plate with pin and a tension band wire (Plate-Pin-TBW) and (c) locking plate with a pin (Plate-Pin).Methods Six pairs of raccoon dog cadaveric tibiae were tested in Phase I Pin-TBW versus Plate-Pin-TBW and seven pairs in Phase II Plate-Pin-TBW versus Plate-Pin. One limb of each pair was randomly assigned to one of two groups for each phase. A tensile force was applied to the patellar ligament until construct failure.Results Pin-TBW (342N ± 54.7N) failed at a lower load than Plate-Pin-TBW (469N ± 77.3N), p = 0.00748, with all Pin-TBW failing by fracture and the majority of Plate-Pin-TBW failing by rupture of patellar ligament. Pin-TBW group Phase I, normalized with Plate-Pin-TBW Phase I, failed at a lower load than Plate-Pin group Phase II, normalized with Plate-Pin-TBW Phase II, p = 0.00467. There was no significant difference in mean load at failure, stiffness or mode at failure between the groups in the Phase II study.Clinical Significance Although ex vivo mechanical testing does not replicate the postoperative live dog or cat, these results demonstrate lower construct strength of the Pin-TBW construct compared with the Plate-Pin construct in the raccoon dog cadaver model.
The interphonology of contemporary English corpus (IPCE-IPAC)
Authors: Herry-Bénit Nadine , Lopez Stéphanie , Kamiyama Takeki , Tennant Jeff 
Published: October 2021

Abstract
This article presents the IPCE-IPAC corpus, an ongoing project, which has been collected in France, Italy, Spain
and China since 2014. The data is collected to investigate the acquisition of segmental and suprasegmental phenomena by L2
learners of English, with a focus on phonemes. The article discusses the methods for the compilation of this original spoken
learner corpus, designed to study L2 “interphonology” (Detey, Racine, Kawaguchi, & Zay,
2016), or interlanguage phonology.
Lexical diversity in an L2 Spanish learner corpus
Authors: Fernández-Mira Paloma , Morgan Emily , Davidson Sam , Yamada Aaron , Carando Agustina , Sagae Kenji , Sánchez-Gutiérrez Claudia H. 
Published: October 2021

Abstract
This study examines the impact of two topic-related variables (i.e., valence polarity and everyday-life closeness)
on the lexical diversity scores (i.e., MTLD) of learners of L2 Spanish at different proficiency levels. The analysis included
3,045 texts written in response to two pairs of prompts by 1,165 students enrolled in an L2 Spanish program. The first pair of
prompts asked learners to narrate an event: prompt 1 focused on a perfect vacation (positive event), while prompt 2 asked
participants to tell a terrible story (negative event). The second pair asked to describe a person: prompt 1 required that the
subject be famous, thus not close to the writer, whereas prompt 2 required that the subject be special and close to the writer.
Results indicate that lexical diversity scores were higher for the texts written about the positive event and the famous subject
across all proficiency levels.
Interpretations based on delayed-domain (dis)appearance in printed advertising
Authors: Herrero-Ruiz Javier 
Published: October 2021

AbstractIn the Cognitive Linguistics literature, the way viewers understand printed ads whose interpretation is based on metaphors and/or metonymies is conditioned by the principle whereby the source and target domains are called upon by the linguistic expression at roughly the same time (cf.Gibbs, 2006).Nonetheless,Herrero-Ruiz (2019)has shown how certain contextual effects are generated when one of the metaphoric/metonymic domains appears at a later stage in the interpretation process (directvs.delayed domain appearance). In this paper, we shall describe various analytical patterns grounded in this new perspective as well as the specific interpretive routes that they imply. In doing so, we offer an alternative to the existing approaches that try to account for the possible interpretations printed ads based on metaphors and/or metonymies may elicit.
Gastric neurons in the nucleus tractus solitarius are selective to the orientation of gastric electrical stimulation
Authors: Cao Jiayue , Wang Xiaokai , Powley Terry L , Liu Zhongming 
Published: October 2021

Abstract

Objective. Gastric electrical stimulation (GES) is a bioelectric intervention for gastroparesis, obesity, and other functional gastrointestinal disorders. In a potential mechanism of action, GES activates the nerve endings of vagal afferent neurons and induces the vago-vagal reflex through the nucleus tractus solitarius (NTS) in the brainstem. However, it is unclear where and how to stimulate in order to optimize the vagal afferent responses. Approach. To address this question with electrophysiology in rats, we applied mild electrical currents to two serosal targets on the distal forestomach with dense distributions of vagal intramuscular arrays (IMAs) that innervated the circular and longitudinal smooth muscle layers. During stimulation, we recorded single and multi-unit responses from gastric neurons in NTS and evaluated how the recorded responses depended on the stimulus orientation and amplitude. Main results. We found that NTS responses were highly selective to the stimulus orientation for a range of stimulus amplitudes. The strongest responses were observed when the applied current flowed in the same direction as the IMAs in parallel with the underlying smooth muscle fibers. Our results suggest that gastric neurons in NTS may encode the orientation-specific activity of gastric smooth muscles relayed by vagal afferent neurons. Significance. This finding suggests that the orientation of GES is critical to effective engagement of vagal afferents and should be considered in light of the structural phenotypes of vagal terminals in the stomach.
Integral order photonic RF signal processors based on a soliton crystal micro-comb source
Authors: Tan Mengxi , Xu Xingyuan , Wu Jiayang , Corcoran Bill , Boes Andreas , Nguyen Thach G , Chu Sai T , Little Brent E , Morandotti Roberto , Mitchell Arnan , Moss David J 
Published: October 2021

AbstractSoliton crystal micro-combs are powerful tools as sources of multiple wavelength channels for radio frequency (RF) signal processing. They offer a compact device footprint, a large number of wavelengths, very high versatility, and wide Nyquist bandwidths. Here, we demonstrate integral order RF signal processing functions based on a soliton crystal micro-comb, including a Hilbert transformer and first, second and third-order differentiators. We compare and contrast the results and the trade-offs involved with varying the comb spacing, and tap design and shaping methods.
MS2AI: automated repurposing of public peptide LC-MS data for machine learning applications
Authors: Rehfeldt Tobias Greisager , Krawczyk Konrad , Bøgebjerg Mathias , Schwämmle Veit , Röttger Richard 
Published: October 2021

Abstract

Motivation
Liquid-chromatography mass-spectrometry (LC-MS) is the established standard for analyzing the proteome in biological samples by identification and quantification of thousands of proteins. Machine learning (ML) promises to considerably improve the analysis of the resulting data, however, there is yet to be any tool that mediates the path from raw data to modern ML applications. More specifically, ML applications are currently hampered by three major limitations: (i) absence of balanced training data with large sample size; (ii) unclear definition of sufficiently information-rich data representations for e.g. peptide identification; (iii) lack of benchmarking of ML methods on specific LC-MS problems.

Results
We created the MS2AI pipeline that automates the process of gathering vast quantities of MS data for large-scale ML applications. The software retrieves raw data from either in-house sources or from the proteomics identifications database, PRIDE. Subsequently, the raw data are stored in a standardized format amenable for ML, encompassing MS1/MS2 spectra and peptide identifications. This tool bridges the gap between MS and AI, and to this effect we also present an ML application in the form of a convolutional neural network for the identification of oxidized peptides.

Availability and implementation
An open-source implementation of the software can be found at https://gitlab.com/roettgerlab/ms2ai

Supplementary information
Supplementary data are available at Bioinformatics online.
Reflections after TWILIGHT study: a new era in secondary prevention without aspirin?
Authors: Occhipinti Giovanni , Capodanno Davide 
Published: October 2021

Abstract
Dual antiplatelet therapy (DAPT) is mandatory in patients undergoing percutaneous coronary interventions (PCIs), but carries an increased bleeding risk which must be weighed over the expected antithrombotic benefit. In recent years, DAPT optimization strategy has been enriched by the concept of early withdrawal of aspirin (‘aspirin-free’ strategy). This strategy is supported by the modern advancements in pharmacological and procedural fields (i.e. the availability of P2Y12 receptor inhibitors with a concomitant ‘aspirin-like’ effect), the advocated use of pharmacological non-antiplatelet secondary prevention strategies (i.e. angiotensin-converting enzyme inhibitor, statins, beta-blockers), the use of modern stents and the increasingly widespread use of intra-coronary imaging techniques. In the last few years, five clinical trials (GLOBAL LEADERS, TWILIGHT, STOP-DAPT2, SMART CHOICE, TICO) and their own meta-analysis have been followed, aiming to evaluate the efficacy and safety of different ‘aspirin-free’ strategies. They showed that aspirin withdrawal (1–3 months after PCI), determines a consistent reduction of bleeding risk, without compromising efficacy endpoints. It resulted in a class IIa indication in the 2020 European Society of Cardiology Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation, which suggested the early withdrawal of aspirin in patients undergoing PCI and considered to be at low ischaemic and low bleeding risk, or at high bleeding risk.