bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Sigh of Relief: Vaccine-Associated Hypermetabolic Iymphadenopathy Following the Third Covid-19 Vaccine Dose is Short in Duration and Uncommonly Interferes with the Interpretation of [18F]FDG PET-CT Studies Performed in Oncologic Patients
Authors: Cohen Dan , Krauthammer Shir Hazut , Wolf Ido , Even-Sapir Einat 
Published: September 2021

Abstract
Purpose: The incidence of Covid-19 vaccine-associated hypermetabolic lymphadenopathy (VAHL) is high following the administration of the first and second BNT162b2 vaccine doses. The impact of this finding on [18F]FDG PET-CT interpretation and its correlation with the induced humoral immunity have been reported. Assuming the amnestic immune response is different following the third vaccine dose, we aimed to explore the incidence of VAHL over time after the third BNT162b2 dose administration, and its relevance to [18F]FDGPET-CT interpretation in oncologic patients.Methods: A total of 179 consecutive oncologic patients that underwent [18F]FDG PET-CT after a third BNT162b2 vaccine dose were included. The presence of VAHL was assessed. On VAHL-positive scans, the SUVmax, number, location and size of the“hot” nodes were recorded. The median time interval between vaccination and imagingwas 8 (IQR,5-14) days.Results: The incidences of all-grade VAHL and grade 3-4 VAHL were 47.5% and 8.9%,respectively. VAHL was identified on 82.5% of studies performed within the first 5 days from vaccination. Grade 3-4 VAHL was observed on 28.1% of studies performed within the first 5 days from vaccination, but was not detected on studies performed more than 5 days from vaccination. Separation between VAHL and malignant lymphadenopathy was not possible in only 2 of the 179 study patients. On a multivariable logistic regression, independent predictors of grade 3-4 VAHL were short time interval between vaccination and imaging (Pv<0.01), younger age (Pv<0.01) and lower BMI (Pv=0.03).Conclusion: VAHL is commonly identifiedon [18F]FDG PET-CT performed within the first 5 days from the third BNT162b2 vaccine doseadministration. High-grade VAHL is unlikely to be observed on a scan performed 6 days or longer from vaccination, and is even less likely in older and obese patients.
Data-driven Product Functional Configuration: Patent Data and Hypergraph
Authors: Lin Wen-Guang , Liu Xiao-Dong , Xiao Ren-bin 
Published: September 2021

Abstract
Product functional configuration (PFC) is a common way for the firm to satisfy individual requirements of the customer and be carried out base on market analysis. This study aims to help firms analyze functions and carry out function configuration by the patent data. This paper proposes a patent data-driven product function configuration method based on a hypergraph network. It constructs a weighted network model to optimize the combination of product function quantity and object from the perspective of big data: (1) The functional knowledge contained in the patent is extracted. (2) The functional hypergraph (FH) is constructed according to the co-occurrence relationship of patent and applicant. (3) The function and patent weight are calculated from the perspective of the patent applicant and patent value. (4) The weight calculation model of PFC is built. (5) The weighted frequent subgraph algorithm is used to obtain the optimal function combination list. This method is applied in the innovative design process of a bathroom shower. The result indicates that this method designed in the study has a positive effect on helping firms detach optimal function candidates and develop a multi-function product.
Hot Temperature OGTT Induces Higher Insulin and GLP-1 Response Than Cold OGTT
Authors: Hu Yun , Zhang Peng , Ding Bo , Cao Xin , Zhong Yi , Sun Yi-Xuan , Lee Kok-Onn , Ma Jian-Hua 
Published: September 2021

Abstract
Food temperature may be important in diabetes. Newly diagnosed treatment-naïve type 2 diabetes patients (T2DM, 22) and normal controls (19) were randomly assigned to either hot (50°C) or cold (8˚C) oral glucose tolerance test (OGTT) on day 1, and OGTT at the other temperature on the next day. Measurements were made on venous blood obtained at 0, 5, 10, 30, 60, and 120 min. Compared to cold OGTT, blood glucose was significantly higher with hot OGTT in both groups. However, insulin and glucagon-like peptide-1 (GLP-1) levels were significantly higher in hot OGTT in normal subjects only. The glucose-dependent insulinotropic peptide (GIP) and cortisol responses did not differ with temperature in both groups. After the OGTT, subjects took corresponding, either hot (> 42˚C) or cool (room temperature) meals and water, that entire day, followed by identical food at the other temperature the next day. Continuous glucose monitoring showed that normal subjects had significantly higher 24-hour mean glucose (MBG), and standard deviation of MBG with hot meals, T2DM patients had higher MBG only. Our study showed that blood glucose, insulin, and GLP-1 responses to different food temperatures may be deficient in newly diagnosed T2DM.
Enhanced Dialog between Formal and Informal Caregivers: Following a User-centered Design for Personas' Development
Authors: Varella Annita , Dratsiou Ioanna , Romanopoulou Evangelia , Pinaka Ourania , Routa Evlampia , Gioulekas Fotios , Stamatiadis Evangelos , Tzikas Athanasios , Gounaris Konstantinos , Xiromerisiou Georgia , Tavel Peter , Bamidis Panagiotis D. 
Published: September 2021

Abstract
Background

The unprecedented increase in ageing population in recent decades has led to a shift in the epidemiological profile of societies, resulting in an increased prevalence of chronic diseases, cognitive impairments, and sensory loss in older adults and their elevated reliance on both formal and informal caregiving. Caregivers hold a vital role in older adults’ healthcare, yet their health and well-being needs are often undermined. This paper ventures the exploration of both formal and informal caregivers’ profiles through the development of personas.
Methods

Formal caregivers (N = 71) and informal caregivers (N = 54) were recruited in the study participating both in quantitative surveys and ad-hoc interviews including the measures Job Stress Scale, Zarit Burden Interview, Short Form Health Survey (SF-36) and Persona Perception Scale.
Results

Upon the analysis of the Persona Perception Scale and Job Stress Scale, the findings revealed high reliability scores, designating that the formal caregiver persona ‘’Daphne’’ could adequately represent the actual target group. The results also showed that the informal caregiver persona ‘’Elle’’ was an accurate reflection of the corresponding target group, after analyzing the findings retrieved from quality of life measurements and caregivers’ burden.
Conclusions

User personas can enhance a deeper understanding of the target group and apprehend user preferences and experiences. To this end, personas can potentially provide empathetic and expansive benefits and be exploited as artifacts in attempting to successfully liaise with policy-makers and care providers in aligning key strategies and policies that will conclusively improve the quality of life of both care recipients and caregivers.
Predicting Menstrual Recovery After Laparoscopic Sleeve Gastrectomy in Polycystic Ovary Syndrome Women With Obesity
Authors: Cai Meili , Zhang Yuqin , Gao Jingyang , Dilimulati Diliqingna , Lin Ziwei , Bu Le , Cheng Xiaoyun , Du Lei , Zhou Donglei , Zhu Jiangfan , Qu Shen , Zhang Manna 
Published: September 2021

Abstract
Objectives: To investigate the recovery of menses in polycystic ovary syndrome (PCOS) women with obesity after laparoscopic sleeve gastrectomy (LSG), and to explore the predictors for menstrual recovery. Methods: A total of 88 PCOS patients with obesity and 76 control patients with obesity aged 18-45 years were enrolled between May 2013 and December 2020. Preoperative clinical characteristics, metabolic parameters and sex hormones were collected. Postoperative menstrual status, body weight and use of oral contraceptives were obtained through telephone follow-up. Results: Patients with PCOS were followed up for at least six months after surgery, and the mean follow-up time was 3.23 years. About 24.66% of patients with PCOS started their first menstruation after LSG within 7 days, and 79.52% patients had regular menstruation at six months after LSG. In logistic regression analyses, duration of PCOS ≤4.5 years (P=0.007), number of preoperative menstruation per year >4.0 times/year (P=0.045), homeostatic model assessment of insulin resistance (HOMA-IR) ≤7.3 (P=0.020) and total testosterone (TT) ≤1.5 nmol/L (P=0.029) at baseline were significantly associated with menstrual resumption in PCOS patients within 6 months after LSG. After adjusting confounders, combination of four clinical indices at baseline could effectively predict menstrual recovery in PCOS patients within 6 months after LSG (AUC=0.837, [95%CI: 0.735-0.939], P<0.001). Conclusion: Overall, the combination of PCOS duration, menstruations per year, HOMA-IR and TT at baseline could be used as an effective tool for the prediction of menstrual recovery in PCOS patients within 6 months after LSG, which can be applied in preoperative evaluation.
Kinetic Changes in Serum KL-6 Levels Predict Disease Progression in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease: A Retrospective Observational Study
Authors: Watanabe Satoshi , Kase Kazumasa , Saeki Keigo , Ohkura Noriyuki , Murata Akari , Waseda Yuko , Takato Hazuki , Ichikawa Yukari , Yasui Masahide , Kasahara Kazuo 
Published: September 2021

Abstract
Background: The clinical course of patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) is highly variable. The Krebs von den Lungen-6 (KL-6) glycoprotein is a promising biomarker for reflectingepithelial injury. However, serum KL-6 and its association with the progression of SSc-ILD have been understudied. Methods: We reviewed 77 consecutive patients with SSc-ILD seen from 2004 to 2016. A longitudinal study of forced vital capacity (FVC), serum KL-6 levels, and the changes in KL-6 levels from baseline (ΔKL-6) was conducted. The progression of ILD was defined as ≥10% relative decline in FVC predicted or 5%–10% decline in FVC predicted along with radiological progression on chest computed tomography. The risk factors for ILD progression were assessed by univariate and multivariate regression.Results: The 77 study patients included 58 women (75%). The median age of the study patients was 56 years, and 59 (79%) patients had diffuse cutaneous SSc. During a 5-year follow-up period, 10 (13%) showed rapid progression of ILD within 2 years, 39 (51%) had overall progressionduring the 5 years, and 28 (36%) had stable disease. Most patients with progressive ILD showed elevationsin serum KL-6 levels over the initial 1-year follow-up period. The best cut-off value for ΔKL-6 that predicted progression of ILD was 193 U/mL (sensitivity 81.6%, specificity 92.9%). Multivariate analysis with adjustment revealed that diffuse cutaneous SSc(hazard ratio [HR] 3.1; 95% confidence interval [CI] 1.05-9.36]) and ΔKL-6 > 193 U/mL from baseline(HR, 4.7; 95% CI, 2.14-10.4)were independent predictors for progression of SSc-ILD.Conclusion: Changes in the KL-6 level can be useful for predicting disease progression in patients withSSc-ILD.
Electrochemical And DFT Investigations of Anticorrosive Potentials of Selected Sulphonamides Based On Adsorption At Aluminium/Aqueous Acid Interface
Authors: Murulana Lutendo C. , Nesane Tshimangadzo , Kabanda Mwadham M. , Olasunkanmi Lukman O. , Ebenso Eno E. 
Published: September 2021

Abstract
The anticorrosive properties of six (6) selected sulphonamide derivatives on the aluminium surface were investigated in order to reveal their mechanism and mode of adsorption on Al/HCl interface, as well as the strength of the interactions between the inhibitor and Al surface. Electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP) techniques were utilised to evaluate the inhibition efficiencies of the selected compounds, while scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy techniques were utilised to understand the surface morphology of Al and adsorption sites of the sulphonamides. Density functional theory (DFT) calculations were utilised to investigate the strength of interactions between the inhibitor molecules and Al. Corrosive electrolyte of 1 M hydrochloric acid was employed in the study. All the studied sulphonamides showed excellent corrosion inhibition efficiencies with maximum values of up to 95%-97% at the optimum concentrations (4 × 10-5 M - 4 × 10-5 M), based on EIS measurements. The EIS parameters further revealed adsorbed film of the sulphonamides on the Al surface with capacitive-inductive characters. All the six sulphonamides reduced the corrosion current densities for both anodic and cathodic half-reactions and shifted the corrosion potentials to some anodically nobler values as revealed by the PDP data. Adsorption of the sulphonamides at the Al/HCl interface was described by the Langmuir isotherm model. Surface protection properties of the sulphonamides were further confirmed by SEM plates that showed less damaged surface of Al for the inhibited process compared to the uninhibited one. DFT results suggest that the binding energy for the inhibitors on the Al surface results in an energy that is less than 30 kJ/mol, which is an indication that the interactions are van der Waal type of interaction, suggesting physisorption mechanism.
Synthesis, cytotoxicity, apoptosis and cell cycle arrest of a ruthenium multi-substituted Keggin-type polyoxotungstate
Authors: Jia Shifang , Wen Yanzhen , Hao Xiuli , Zhang Yan 
Published: September 2021

Abstract
The ruthenium multi-substituted polyoxotungstate with chemical formulae of K7[SiW9O37Ru4(H2O)3Cl3]·15H2O (S1) was synthesized by a conventional aqueous solution containing the trilacunary Keggin-anions β-Na9HSiW9O34·12H2O(S2) and RuCl3·nH2O(S3). Compound S1 was characterized by elemental analyses, EDS, TG analyses, IR, UV/Vis and XPS. The cytotoxic potential of compound S1 was tested on C33A, DLD-1, HepG-2 cancer cells and human normal embryonic lung fibroblasts cell MRC-5. The viability of the treated cells was evaluated by MTT assay. The mode of cell death was assessed by morphological study of DNA damage and apoptosis assays. Compound S1 induced cell death in a dose-dependent manner, and the mode of cell death was essentially apoptosis though necrosis was also noticed. Cell cycle analysis by flow cytometry indicated that compound S1 caused cell cycle arrest and accumulated cells in S phase.
Effects of Structural Symmetry on NMR Spectra of 3,9-Diazatetraasteranes
Authors: Sun Runzhi , Song Xiuqing , Xie Fan , Wang Huiqin , Yan Hong 
Published: September 2021

Abstract
The structural symmetry is of great significance on the unique physical and chemical properties that closely related to pharmacological applications. To investigate the effects of structural symmetry on the NMR spectra, C2-3,9-diazatetraasteranes and non-C2-3,9-diazatetraasteranes were selected as the research object. They were synthesized by the self-dimerization and cross-dimerization of diethyl 1,4-dihydropyridine-3,5-dicarboxylates, respectively. The differences and similarities in NMR spectra of these two types of 3,9-diazatetraasteranes were discussed by the 1D-NMR and 2D-NMR analysis. The single-crystal X-ray diffraction (XRD) was used to demonstrate directly their structural symmetry.
Pretreatment With a Long-acting GnRH Agonist in Early Follicular Phase Increases Clinical Pregnancy Rate in Frozen-thawed Embryo Transfer Cycles
Authors: xu Bin , Zhao Jing , Hou Zhaojuan , Liu Nenghui , Li Yanping 
Published: September 2021

Abstract
Background: It is controversial whether gonadotropin-releasing hormone agonist (GnRHa) pretreatment can benefit the pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. In most of studies, GnRHa was administered during the mid-luteal phase for pretreatment. Few studies focus on FET cycles with GnRHa administered in early follicle phase.Methods: The retrospective cohort study was conducted in a university-affiliated IVF center. 630 patients in the GnRHa FET group and 1141 patients in the hormone replacement treatment (HRT) FET without GnRHa group from October 2017 to March 2019 were included. The menstruation cycle of these patients was irregular. Results: There were no differences observed between the two groups in patient’s characteristics. However, the GnRHa FET group showed a higher percentage of endometrium with triple line pattern (94.8% vs 89.6%, p<0.001) on the day of progesterone administration, and an increased implantation rate (34.7% vs 30%, p<0.01), biochemical pregnancy rate (60.6% vs 54.3%, p = 0.009), and clinical pregnancy rate (49.8% vs 43.3%, p = 0.008), as compared to that in the HRT FET cycles with similar endometrial thickness, ectopic pregnancy rate, and early miscarriage rate. Binary logistic regression analysis showed the GnRHa FET group to be associated with an increased chance of clinical pregnancy rate compared with HRT FET without GnRHa group (P=0.014, odds ratio [OR] 1.30, 95% confidence interval [CI] 1.06-1.61).Conclusions: Pretreatment with a long-acting GnRHa in early follicular phase can improve the clinical outcome of the FET cycles. However, further randomized control trials (RCTs) will be needed to verify these results.
Progestin-primed Ovarian Stimulation With Clomiphene Citrate Compared With the Standard Progestin-primed Ovarian Stimulation in Various Aged Women With Diminished Ovarian Reserve: a Retrospective Study
Authors: Lin Yue , Chen Qianqian , Zhu Jing , Teng Yili , Huang Xuefeng , Chen Xia 
Published: September 2021

Abstract
Background: Clomiphene citrate (CC) supplementation in the progestin-primed ovarian stimulation (PPOS) protocol effectively alleviated profound pituitary suppression from progestin administration and reduced the gonadotropin (Gn) dose in the population of women with normal-ovarian-reserve or polycystic ovarian syndrome. Limited data are available about the role of CC in PPOS for women with diminished ovarian reserve (DOR). This study aimed to compare the efficiency of the PPOS protocol with CC supplementation and the standard PPOS protocol for various aged women with DOR.Methods: A total of 364 patients with DOR were recruited for this retrospective cohort study. They were divided into subgroups based on female age, ≤35 years and ＞35 years. The clinical characteristics and outcome were compared between the groups in subgroups.Results: In all patients with DOR, the PPOS protocol with CC supplementation was associated with a lower percentage of women with profound pituitary suppression (0.0% vs 18.6%, P ＜0.001 and 1.3% vs 11.0%, P ＝0.002) and a higher mean luteinizing hormone (LH) level during controlled ovarian stimulation (COS) than the standard PPOS protocol (P ＜0.05＝. In young women with DOR, more number of high-quality cleavage-stage embryos (1.96 vs. 1.38, P ＝0.018) was achieved in the PPOS protocol with CC supplementation. In elderly women with DOR, PPOS protocol with CC supplementation led to an increase in the incidence of LH levels above 10 IU/L on the trigger day (12.7% vs. 4.9%, P ＝0.028) and decrease in the rate of oocyte maturation (84.7% vs. 89.9%, P ＝0.034) compared to the standard PPOS protocol. No significant differences were observed in the Gn duration, total dosage of Gn, and pregnancy outcomes between the groups. Conclusions: CC is an effective adjuvant to alleviate pituitary suppression in the PPOS protocol. For young women with DOR, CC supplementation has a positive impact on the number of high-quality embryos in PPOS protocol. However, elderly patients with DOR would be at risk of developing premature LH surge and poor oocyte maturation rate after the PPOS protocol with CC supplementation was applied.
The Association between Weather Conditions (Ambient Air Temperature and Relative Humidity) with Coronavirus Disease (COVID-19) Risk in Bandar Abbas, Iran
Authors: Fakhri Yadolah , Hadei Mostafa , Rostami Ali , Mouseli Ali 
Published: September 2021

Abstract
Background: This study was devoted to evaluate the association between COVID-19 infection and weather conditions in Bandar Abbas, Iran. Methods: The positive cases data was retrieved from the Ministry of Health and Medical Education of Iran (MOHME) and weather conditions from the Iran meteorological organization (IMO) from the 01, October 2020 to 27, November 2020. The components of weather consist of average of the ambient air temperature (°C) and relative humidity (%). The Spearman correlation test was used to determine the association between weather conditions (temperature and relative humidity) with COVID-19 infection.Results: Spearman analysis showed that air temperature (Coefficient = -0.303 and P-value = 0.001) were negatively associated with COVID-19 infection. However, no significant association was observed between relative humidity (Coefficient = 0.088 and P-value = 0.340) and COVID-19 infection. Hence, the ambient air temperature can be considered as a considerable variable in the COVID-19 infection in Bandar Abbas. Conclusions: The results of this study can be used for prevention and control of COVID-19 infection in areas with similar meteorological conditions in world.
AEBP1 Predicts Clinical Prognosis and is Associated with Immunocyte Infiltration in Gastric Cancer
Authors: Deng Junsheng , Zhan Ting , Chen Xiaoli , Wan Yiyuan , Chen Mengge , Liu Jiaxi , Tian Xia , Huang Xiaodong 
Published: September 2021

Abstract
AEBP1 is differentially expressed in various tumors. However, the correlation between AEBP1 and immune cell infiltration in gastric cancer remains unclear. Kaplan-Meier survival curves were used to evaluate the relationship between AEBP1 expression and overall survival and progression-free survival. The relationship between AEBP1 expression and infiltrating immune cells, and their corresponding gene marker sets was examined using the TIMER database.The expression of AEBP1 was lower in gastric cancer (GC) tumor tissues than in normal tissues (P < 0.05). High AEBP1 gene expression and high levels of AEBP1 gene methylation were correlated with high-grade malignant tumor and old TNM stage. In addition, in gastric cancer, there was a positive correlation between AEBP1 expression and immune infiltrating cells, including neutrophils, CD8 + T cells, and CD4 + T cells, as well as immune-related genes, including CD2, CD3D, and CD3E. Methylation sites such as cg00009293, cg08495088, cg12955216, cg10480062, cg06852744 and cg12978582 were positively correlated with low expression of AEBP1. AEBP1 may be a potential tumor suppressor gene in GC and a potential novel therapeutic target and predictive biomarker for GC. AEBP1 likely plays an important role in immune cell infiltration.