bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Nutritional Status of Children With Congenital Heart Disease: A Comparative Study
Authors: Chinawa Awoere T. , Chinawa Josephat M. , Duru Chika Onyinyechi , Chukwu Bartholomew F. , Obumneme-Anyim Ijeoma 
Published: September 2021

Background: Malnutrition poses a great burden to children in the tropics. However, this seems to be accentuated in children with congenital heart disease.Objectives: The present study is therefore aimed at determining the nutritional status of children with congenital heart disease and to compare them with those without congenital heart disease.Methods: This is a cross-sectional study, where congenital heart disease was diagnosed by means of echocardiograph. Anthro software was used to calculate Z scores for weight for age (WAZ), height for age (HAZ), and weight for height (WHZ). Body mass index (BMI) was calculated by the formula BMI = Weight (Kg)/height (M2).Results: The body mass index-for-age z-score (BAZ) and height/length-for-age z-score (HAZ) were calculated for both subjects and controls to determine their nutritional status. It was observed that 38.5% (112/291) of the subjects were wasted (BAZ &lt; −2SD) compared to 6.25% (16/256) of the controls and the difference was statistically significant (χ2 = 81.2, p &lt; 0.001). Stunting (height/length-for-age z-score &lt; −2SD) was also observed in a greater proportion of subjects than controls as 37.8% (107/291) of subjects were stunted compared with 7.0% (18/256) of the controls (χ2 = 69.9, p &lt; 0.001). The under-five subjects had more cases of malnutrition than the controls of same age group as illustrated in Table 6. Whereas 42.9% (96/224) of the under-five subjects were wasted, only 6.2% (12/192) of the controls were wasted. On the other hand, 4.2% (8/192) of the under-five controls were obese compared to 0.9% (2/224) of the subjects of similar age group.Conclusion: Children with congenital heart disease present with varying degrees of malnutrition that is worse compared with children without congenital heart disease. The impact of malnutrition is worse among children under the age of five. Wasting is more prevalent in children with cyanotic heart disease compared with those with acyanotic congenital heart disease. Overweight and obesity were notable features of malnutrition in children with congenital heart disease, but this is worse in children without congenital heart disease.
Immune Infiltration of MMP14 in Pan Cancer and Its Prognostic Effect on Tumors
Authors: Li Minde , Li Shaoyang , Zhou Lin , Yang Le , Wu Xiao , Tang Bin , Xie Shenhao , Fang Linchun , Zheng Suyue , Hong Tao 
Published: September 2021

BackgroundMatrix metalloproteinase 14 (MMP14) is a member of the MMP family, which interacts with tissue inhibitors of metalloproteinase (TIMPs), and is involved in normal physiological functions such as cell migration, invasion, metastasis, angiogenesis, and proliferation, as well as tumor genesis and progression. However, there has been a lack of relevant reports on the effect of MMP14 across cancers. This study aims to explore the correlation between MMP14 and pan-cancer prognosis, immune infiltration, and the effects of pan-cancer gene mismatch repair (MMR), microsatellite instability (MSI), tumor mutational burden (TMB), DNA methylation, and immune checkpoint genes.MethodsIn this study, we used bioinformatics to analyze data from multiple databases, including The Cancer Genome Atlas (TCGA), ONCOMINE, and Kaplan–Meier plotter. We investigated the relationship between the expression of MMP14 in tumors and tumor prognosis, the relationship between MMP14 expression and tumor cell immune infiltration, and the relationship between MMR gene MMR, MSI, TMB, DNA methylation, and immune checkpoint genes.ResultsMMP14 expression is highly associated with the prognosis of a variety of cancers and tumor immune invasion and has important effects on pan oncologic MMR, MSI, TMB, DNA methylation, and immune checkpoint genes.ConclusionMMP14 is highly correlated with tumor prognosis and immune invasion and affects the occurrence and progression of many tumors. All of these results fully indicate that MMP14 may be a biomarker for the prognosis, diagnosis, and treatment of many tumors and provide new ideas and direction for subsequent tumor immune research and treatment strategies.
Histiocytic Necrotizing Lymphadenitis Mimicking Acute Appendicitis in a Child: A Case Report
Authors: Hua Chun-Zhen , Chen Yu-Kai , Chen Shun-Zhi , Gu Wei-Zhong , Shu Qiang 
Published: September 2021

Background: Histiocytic necrotizing lymphadenitis, also known as Kikuchi-Fujimoto disease (KFD), is a self-limiting inflammatory disease with low incidence and high misdiagnosis rate in children. Furthermore, cases where the clinical presentation resembles acute appendicitis are very rare.Case Presentation: A 14-year-old boy was misdiagnosed as acute appendicitis and received operative treatment at his early visit. He suffered from abdominal pain, vomiting, diarrhea, fever, and lymphadenitis at the ileocecal junction, which were found by B-ultrasonography examination and surgery. Lymphadenectomy, as well as appendectomy, was performed, and KFD was identified by pathological examination. The patient was transferred to our hospital for further therapy because of recurrent fever and abdominal pain after the appendectomy. His temperature became normal after methylprednisolone was administered, and no recurrence was observed till now during follow-up.Conclusions: Necrotizing lymphadenitis involving mesenteric lymph nodes may cause acute-appendicitis-like symptom; KFD should be a diagnostic consideration for mesenteric lymphadenitis.
Non-Coding RNA Polymorphisms (rs2910164 and rs1333049) Associated With Prognosis of Lung Cancer Under Platinum-Based Chemotherapy
Authors: Chen Yi-Xin , Chen Juan , Yin Ji-Ye , Zhou Hong-Hao , He Bai-Mei , Liu Zhao-Qian 
Published: September 2021

Purpose: Lung cancer is the largest cause of cancer deaths in the world. Platinum-based chemotherapy is a foundation of first-line chemotherapy. However, the prognosis of lung cancer treated with platinum-based chemotherapy is still a challenge. Single nucleotide polymorphism of non-coding RNA has the potential to be a biomarker, but its effectiveness has yet to be comprehensively assessed. In this study, we explored the association between polymorphisms of non-coding RNA and prognosis of lung cancer patients receiving platinum-based chemotherapy.Materials and Methods: For 446 lung cancer patients receiving platinum-based chemotherapy, 22 single nucleotide polymorphisms of microRNA and long noncoding RNA were genotyped by MALDI-TOF mass spectrometry. Cox regression analysis, Kaplan-Meier method, and long-rank test have been performed to assess the association of overall and progression-free survival with polymorphisms.Results: In the additive and dominant models, genetic polymorphism of ANRIL rs1333049 (G &gt; C) was significantly associated with progression-free survival. Additive model: CC vs GC vs GG [HR = 0.84, p = 0.021, 95% CI (0.73–0.97)]; Recessive model: CC vs GG + GC [HR = 0.77, p = 0.026, 95% CI (0.61–0.97)]. In the dominant model, compared with the CC genotype patients, lower risk of death [HR = 0.81, p = 0.036, 95% CI (0.66–0.99)] and lower risk of progression [HR = 0.81, p = 0.040, 95% CI (0.67–0.99)] have been observed on the patients with CG or GG genotype in miR-146A rs2910164.Conclusion: Our research demonstrated the potential of using ANRIL rs1333049 (G &gt; C) and miR-146A rs2910164 (C &gt; G) as biomarkers to support the prediction of a better prognosis for lung cancer patients receiving platinum-based chemotherapy.
Effects of Three Preseason Training Programs on Speed, Change-of-Direction, and Endurance in Recreationally Trained Soccer Players
Authors: Koral Jérôme , Lloria Varella Jaume , Lazaro Romero Fernando , Foschia Clément 
Published: September 2021

Background: Modern coaches experience a drastic reduction of the available training time with an increasingly large number of competitions during the competitive season. Thus, they must choose wisely the most efficient methods to improve the physical fitness of their players during the preseason. Among all the methods, this study compared the effects of plyometric training (PT), sprint interval training (SIT), and small-sided games (SSGs) on the performance of recreationally trained soccer players.Methods: Seventy-three participants were randomly assigned in one of the three experimental groups (i.e., PT [n = 23], SIT [n = 26] or SSGs [n = 24]) and completed two sessions per week for a total of 3 weeks. Meanwhile, the whole group maintained their habitual soccer-specific training program who do not interfere in the preparation of the season. Repeated sprint ability (RSA), maximal aerobic speed (MAS), and a 30-m sprint were assessed at baseline (PRE) and post-training (POST).Results: Performance in SSGs decreased for the average speed from 0 to 10 m (V0−10m; −0.84 km h−1, −4 ± 5%, p &lt; 0.001), the maximal distance (Dmax) covered in the 30-s RSA test (−3.65 m, −3 ± 6%, p &lt; 0.01) and MAS (−0.52 km h−1, −3 ± 6%, p &lt; 0.01). PT increased the mean distance (Dmean) covered in the 30-s RSA test (+5.98 m, 5 ± 4%, p &lt; 0.001) and MAS (+0.58 km h−1, 7 ± 5%, p &lt; 0.01) while an improvement of all parameters but the maximal sprint speed reached during the 30-m trip (Vmax) was found in the SIT group (V0−10m: +1.462 km h−1, 8 ± 5%, p &lt; 0.001; Dmax: +7.89 m, 6 ± 5%, p &lt; 0.001; Dmean: +8.69 m, 7 ± 5%, p &lt; 0.001 and MAS: +1.74 km h−1, 12 ± 8%, p &lt; 0.001). All SSG POST values were significantly lower than PT and SIT (p &lt; 0.01). Dmean and MAS in POST were also significantly higher in SIT than in the PT group (p &lt; 0.001).Conclusion: This study suggests that both PT and SIT could be a better alternative to SSGs to boost performances during preseason. Moreover, SIT seems to produce higher improvements in physical performances than PT.
RNase A Inhibits Formation of Neutrophil Extracellular Traps in Subarachnoid Hemorrhage
Authors: Früh Anton , Tielking Katharina , Schoknecht Felix , Liu Shuheng , Schneider Ulf C. , Fischer Silvia , Vajkoczy Peter , Xu Ran 
Published: September 2021

Background: Subarachnoid hemorrhage (SAH) caused by rupture of an intracranial aneurysm, is a life-threatening emergency that is associated with substantial morbidity and mortality. Emerging evidence suggests involvement of the innate immune response in secondary brain injury, and a potential role of neutrophil extracellular traps (NETs) for SAH-associated neuroinflammation. In this study, we investigated the spatiotemporal patterns of NETs in SAH and the potential role of the RNase A (the bovine equivalent to human RNase 1) application on NET burden.Methods: A total number of n=81 male C57Bl/6 mice were operated utilizing a filament perforation model to induce SAH, and Sham operation was performed for the corresponding control groups. To confirm the bleeding and exclude stroke and intracerebral hemorrhage, the animals received MRI after 24h. Mice were treated with intravenous injection of RNase A (42μg/kg body weight) or saline solution for the control groups, respectively. Quadruple-immunofluorescence (IF) staining for cell nuclei (DAPI), F-actin (phalloidin), citrullinated H3, and neurons (NeuN) was analyzed by confocal imaging and used to quantify NET abundance in the subarachnoid space (SAS) and brain parenchyma. To quantify NETs in human SAH patients, cerebrospinal spinal fluid (CSF) and blood samples from day 1, 2, 7, and 14 after bleeding onset were analyzed for double-stranded DNA (dsDNA) via Sytox Green.Results: Neutrophil extracellular traps are released upon subarachnoid hemorrhage in the SAS on the ipsilateral bleeding site 24h after ictus. Over time, NETs showed progressive increase in the parenchyma on both ipsi- and contralateral site, peaking on day 14 in periventricular localization. In CSF and blood samples of patients with aneurysmal SAH, NETs also increased gradually over time with a peak on day 7. RNase application significantly reduced NET accumulation in basal, cortical, and periventricular areas.Conclusion: Neutrophil extracellular trap formation following SAH originates in the ipsilateral SAS of the bleeding site and spreads gradually over time to basal, cortical, and periventricular areas in the parenchyma within 14days. Intravenous RNase application abrogates NET burden significantly in the brain parenchyma, underpinning a potential role in modulation of the innate immune activation after SAH.
Life Events and Adaptive Coping Approaches to Self-Management From the Perspectives of Hospitalized Cardiovascular Patients: A Qualitative Study
Authors: Qiu Ruolin , Tang Leiwen , Wang Xiyi , Ye Zhihong 
Published: September 2021

Objectives: This study aimed to explore the association between hospitalized cardiovascular patients' life events and adaptive coping approaches to self-management.Methods: The study was a qualitative study that was conducted in a cardiology department of one affiliated university hospital in Hangzhou, China. Twenty-eight participants with cardiovascular diseases were recruited through a purposive sampling procedure. Semi-structured interviews were used to gain insights into adaptive coping approaches to self-management when living with different life events. Interviews were audio-recorded and transcribed, and the data were analyzed by thematic analysis.Results: Life events reported by hospitalized cardiovascular participants could be summarized in four categories: daily routines, life changes, life-threatening experiences, and emotional sufferings. The adaptive coping approaches were also summarized in four themes: decision-making, avoidance, consistent responses, and episodic responses.Conclusion: This study described essential insights into the mutual influences between various life events and adaptive coping approaches to self-management by a group of hospitalized cardiovascular patients. Participants coped with their problems flexibly by processing comprehensive information from various and unpredictable life events regarding the situations and contexts. While inequity was cumulated, psychological resilience was a vital mediator between stressful events and their responses. The study illuminated the importance of understanding context, situations, and experiences on how cardiovascular patients adapted to their self-management regimens.
Is Elevated Neutrophil Count and Neutrophil-to-Lymphocyte Ratio a Cause or Consequence of Schizophrenia?—A Scoping Review
Authors: Sandberg Asbjørn Arnesen , Steen Vidar M. , Torsvik Anja 
Published: September 2021

Background: Several studies have found an association between elevated neutrophil count or neutrophil-to-lymphocyte ratio (NLR) in peripheral blood from patients with schizophrenia. The etiology behind this effect is unknown, and it is unclear if changes in neutrophil count and NLR may be induced by antipsychotics or if these parameters relate to the diagnosis and symptoms of schizophrenia. The purpose of this scoping review was to map research that explores this association, and to identify gaps in the current knowledge base.Method: The work was conducted in accordance with established methodological standards for scoping reviews. Studies on neutrophil count and NLR in schizophrenia were identified through search in relevant databases, and a parallel screening procedure was performed to ensure validity and reproducibility of the search. Articles that included different comparison groups, with differences in medication status (drug-naïve or drug-free vs. medicated), current disease state (relapse vs. remission), or treatment response, were included, as well as studies evaluating the association between symptomatology and neutrophil count or NLR.Results: The available literature was limited with substantial differences in aims, methods, and outcomes. In total, 13 articles were included for the synthesis of this review. Some interesting trends were identified: Neutrophil count and NLR seem to be elevated in schizophrenia patients regardless of current or past use of antipsychotic therapy. Neutrophil count and NLR correlated significantly with positive symptoms of schizophrenia. Still, these findings should be interpreted with caution due to considerable methodological differences and weaknesses in the literature, particularly concerning the blood sampling procedure.Conclusion: By including longitudinal studies and by comparing patient groups based on medication status, disease state and response, our study provides a basis for dissecting the associations between increased neutrophil count or NLR and a diagnosis of schizophrenia. Further research should investigate and quantify the apparent strong correlation between neutrophil count or NLR and positive symptoms in schizophrenia, to evaluate its clinical potential to guide diagnostics, treatment, or as a predictor of outcome. This review also exposes important methodological weaknesses in the literature on neutrophil count and NLR measurements. Standardization of blood sampling and processing is crucial to reduce bias, and factors that are known to influence leukocyte levels need to be accounted for.
Chronic Diseases and Labor Force Participation Among Presenile and Senile Chinese
Authors: Qiao Xiaotuo , Wang Bo , Guo Haifeng 
Published: September 2021

Background: The incidence of chronic diseases has increased dramatically due to rapid aging and lifestyle changes of China in recent decades. The population aged more than 45 years is an important participant in the labor force market, and the health status directly affects their labor force participation decision. This study aims to explore the relationship between chronic diseases and the labor force participation among the elderly Chinese population aged more than 45 years.Method: We employ a multivariate probit (MVP) model to construct five structural equations for an analysis. The advantage of this model is that it can deal with the endogeneity of chronic diseases.Results: Firstly, compared with the elderly, younger people are more likely to participate in the labor force market; the influence of chronic diseases is the largest for presenile women in the decision-making of labor force participation; the impact of psychological problems on labor force participation cannot be ignored, especially for men aged more than 45 years. In addition, sociodemographic factors such as geographical location and marital status also have direct effects on the probability of labor force participation while the impact of both family wealth and family number is much smaller. Finally, unhealthy lifestyles through chronic diseases have negative and indirect marginal effects on labor force participation.Conclusions: This article proves that chronic diseases have a negative impact on the labor force participation for Chinese aged more than 45 years. The public should give more tolerance and opportunities to these groups. The population aged more than 45 years are more vulnerable and face more psychological problems, which will lead to a decline in labor force participation. Psychological health counseling and services are urgently needed. As the urban areas enjoy more social welfare, Chinese welfare policy needs to be tilted toward the rural elderly. For individuals, maintaining healthy lifestyles can help you stay away from chronic diseases and stay in the labor force market.
PENSAMIENTO AMBIENTAL DEL MAESTRO: Ethos-Cuerpo en clave de Bio-Geo-Poéticas del Habitar
Authors: Chacón-Ramírez Carlos Alberto 
Published: September 2021

El presente escrito, es emergencia de investigación doctoral en educación, y muestra el trayecto investigativo, de carácter cualitativo, de corte filosófico, epistémico, estético-bio-poético y educativo ambiental, el cual se construye desde un método particular de indagación, a través de lograr la inmersión en instituciones educativas y su itinerancia por ellas, para encontrar anuncios, indicios, rasgos del pensamiento ambiental del maestro, como viáticos, los cuales, se conjugan, se hacen vecinos, en una meseta de pensamiento llamada tendencias de pensamiento ambiental, que en clave filosófica ambiental, se constituye en hallazgo crucial de la tesis. Tesis que además tributa a la transformación del pensamiento ambiental del maestro, a través de una meseta de pensamiento en las claves de modos del habitar la tierra y el pensamiento del mundo de la vida, enunciada como Ethos-Cuerpo en clave de Bio-Geo-Poéticas del Habitar. Finalmente, muestra emergencias investigativas, que anuncian potencias del pensamiento ambiental del maestro, y promueven la incorporación de la filosofía ambiental en su pensamiento ambiental, y de manera decisiva, para la transformación de la educación ambiental.
REPRESENTACIONES SOCIALES DE LA MUJER, EN GÉNOVA Y CALARCÁ, QUINDÍO, DESDE LOS ROLES OCUPACIONALES QUE OCUPAN EN LAS LABORES AGRÍCOLAS Y EN LAS ACTIVIDADES CULTURALES RELACIONADAS CON EL CAFÉ.
Authors: Leal-Larrarte Sandra 
Published: September 2021

En el presente artículo se aborda un análisis de las representaciones sociales que tienen las mujeres de los municipios de Génova y Calarcá, en el Quindío, sobre los roles ocupacionales que ellas ocupan en las labores agrícolas y las actividades culturales relacionadas con el café, considerado este un elemento que ha centralizado la cultura del departamento y ha conformado su funcionamiento económico, proponiendo modos de acción de acuerdo al género pero que han cambiado a partir del concepto que se tiene de la mujer en el siglo XXI. Para lograr dicho objetivo se apelan a los formatos de análisis propuestos por Tania Rodríguez basados en la teoría del núcleo central de Jean Paul Abric (2001), igualmente se relaciona la noción de género como una base conceptual manejada desde la cultura común para la construcción de las representaciones sociales.
EVOLUTION OF GUITAR ART PERFORMANCE TRADITIONS IN THE NATIONAL CULTURAL AND EDUCATIONAL DIMENSION
Authors: Blazhevych Vasyl 
Published: September 2021

The essence and the content of “performing tradition” and “cultural and educational dimension” have been explained in the article. The author examines the history of the emergence and development guitar art in Ukraine as a whole, and specifically performance traditions of the guitarists. Practical educational and performing experience of a lot of prominent guitarists of national cultural and educational dimension, their performing concepts, techniques and methods, has been described; the author gives a complete description of the evolution of guitar art in Ukraine.An objective study of the historical development of national musical culture in today's extremely topical issue in the context of scientific understanding, particularly by disclosing distinctive features of the national musical performance and in particular instrument. Currently growing interest in issues of history, theory and techniques of instrumental performance has been considered, and study of the evolution of performance traditions due to the diversity of the world's musical instruments has been conducted.The XX century has started a process of recognition of the guitar as a professional instrument and it has integrated into the system of specialized music education. As a result of significantly increased quality guitar performance is becoming more popular palette of guitar music; multidisciplinary academic chamber and instrumental direction began to be classical and jazz guitar techniques.Principles and methods of forming performance skills that have been elaborated by practice of Ukrainian and foreign guitarists can be used for further development of musical training and education of talented youth.