bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le modèle du fromage suisse : quand les failles s’additionnent
Authors: Duclos Cinthia 
Published: December 2021

On reconnaît volontiers le rôle des dirigeants dans les succès financiers – et dans les échecs – des entreprises. Mais qu’en est-il de la sécurité des activités d’exploitation et de la protection des clients ? Leur engagement à cet égard est tout aussi primordial. Comment éviter l’effet domino de leurs décisions afin de se prémunir contre de graves perturbations organisationnelles ?
La cohérence culturelle , un levier transformationnel
Authors: Johnson Kevin , Savaria Louis-Philippe , Gril Emmanuelle 
Published: December 2021

Avec la pandémie, les forces et les faiblesses des cultures organisationnelles ont été mises en lumière. Bienveillantes, solidaires, éthiques… Jamais n’aurons-nous eu à ce point conscience de l’importance de la dimension culturelle au sein d’une entreprise ! À cet égard, quelles leçons pouvons-nous tirer, à ce jour, de la période de turbulences que nous avons traversée ?
La conciliation famille-travail, un enjeu de taille pour les gestionnaires
Authors: Agogué Marine , Rampa Romain 
Published: December 2021

Le télétravail et le confinement imposés par la pandémie de COVID-19 ont mis en lumière une préoccupation grandissante pour les gestionnaires : la conciliation famille-travail. Au cœur des politiques en matière de ressources humaines, cette question exige aujourd’hui de repenser certaines postures managériales. Tour d’horizon.
On a lu pour vous – Comment échapper à la dictature du cerveau reptilien, de Didier Pleux
Authors: Jézéquel Myriam 
Published: December 2021

Comment des enfants-rois habitués à donner libre cours à leurs désirs pulsionnels pourront-ils devenir des travailleurs épanouis ? Accepteront-ils les règles, les contraintes et les limites du monde du travail ? Faire prévaloir la raison sur les désirs immédiats : c’est tout l’enjeu de cette lutte contre la toute-puissance du cerveau reptilien. Avis d’un psychologue.
Incidence of Ectasia After SMILE From a High-Volume Refractive Surgery Center in India
Authors: Brar Sheetal , Roopashree C. R. , Ganesh Sri 
Published: December 2021

PURPOSE:
To report the incidence of ectasia after small incision lenticule extraction (SMILE) in a high-volume refractive surgery center in India.

METHODS:
To derive the incidence of ectasia after SMILE, all eyes that underwent SMILE or SMILE Xtra (SMILE combined with prophylactic accelerated corneal cross-linking) from November 2012 to August 2019 were retrospectively analyzed. Furthermore, these cases were classified as being “normal” or “borderline” based on certain predefined criteria. Only eyes with a minimum follow-up of 12 months were included.

RESULTS:

Of the total 7,024 eyes analyzed, 6,619 eyes underwent SMILE, of which 10 eyes developed ectasia at a mean interval of 21.3 months, making the incidence of ectasia after SMILE 0.15%. Of these 10 eyes with ectasia, 2 eyes had normal preoperative topography, whereas the remaining 8 eyes were borderline as per the predefined criteria. Retrospective data analysis revealed that 6,025 of 7,024 eyes were normal and thus suitable for a standard SMILE procedure, whereas 999 eyes were borderline, of which 594 eyes underwent SMILE and 405 eyes underwent SMILE Xtra. The incidence of ectasia in borderline eyes undergoing SMILE was 0.80% (8 of 999) versus 0% (none) for borderline eyes undergoing SMILE Xtra (chi square,
P
< .05).

CONCLUSIONS:
The incidence of ectasia after SMILE in the early postoperative period was 0.15%, with borderline eyes accounting for most cases. Borderline eyes treated with SMILE Xtra did not progress to ectasia, potentially suggesting a protective role of simultaneous CXL.

[
J Refract Surg
. 2021;37(12):800–808.]
Hyperopic SMILE Versus FS-LASIK: A Biomechanical Comparison in Human Fellow Corneas
Authors: Spiru Bogdan , Torres-Netto Emilio A. , Kling Sabine , Hafezi Farhad , Sekundo Walter 
Published: December 2021

PURPOSE:
To investigate the biomechanical properties of ex vivo human paired corneas after hyperopic correction via cap-based versus flap-based laser-assisted refractive surgery.

METHODS:
In this prospective experimental study, 13 pairs of human corneas unsuitable for transplantation were equally divided into two groups. The pachymetry was performed in each eye just before the laser procedure. Corneas from the right eye were treated with small incision lenticule extraction (SMILE), whereas corneas from the left eye of the same donor were treated with femtosecond laser–assisted laser in situ keratomileusis (FS-LASIK). All corneas were subjected to a refractive correction of +6.00 diopters (D) sphere with a 6.5-mm zone under a 120-µm cap (SMILE) or a 7-mm zone under a 110-µm flap (FS-LASIK). For two-dimensional biomechanical measurements, the corneoscleral buttons underwent two testing cycles (preconditioning stress-strain curve from 0.03 to 9.0 N and stress-relaxation at 9.0 N during 120 seconds) to analyze the elastic and viscoelastic material properties. The effective elastic modulus was calculated. Statistical analysis was performed with a confidence interval of 95%.

RESULTS:

In stress-strain measurements, the effective elastic modulus was not significantly different (
P
> .311) between SMILE (13.5 ± 12.8 MPa) and FS-LASIK (7.56 ± 17.9 MPa). In stress-relaxation measurements, the remaining stress was not significantly different (
P
= .841) between SMILE (124 ± 20 kPa) and FS-LASIK (126 ± 21 kPa).

CONCLUSIONS:
Unlike myopic correction, after hyperopic correction the cap-based procedure (SMILE) and the flap-based technique (FS-LASIK) may be considered equivalent in terms of biomechanical stability when measured experimentally in ex vivo human fellow eye corneas.

[
J Refract Surg
. 2021;37(12):810–815.]
Visual and Refractive Outcomes of Toric Implantable Collamer Lens Implantation in Stable Keratoconus After Combined Topography-Guided PRK and CXL
Authors: Sakla Hani F. , Altroudi Wasim , Sakla Yousef F.R. , Muñoz Gonzalo , Pineza Catia 
Published: December 2021

PURPOSE:
To evaluate the safety and efficacy of toric implantable Collamer lens (ICL) (STAAR Surgical) implanted at least 6 months after combined topography-guided photorefractive keratotomy (TG-PRK) and corneal cross-linking (CXL) in keratoconus.

METHODS:
This retrospective study included 46 eyes with keratoconus of 31 patients who underwent toric ICL implantation after previous TG-PRK+CXL. Patients were examined for uncorrected (UDVA) and corrected (CDVA) distance visual acuity, flat and steep keratometry, and manifest refraction spherical equivalent preoperatively and 12 months postoperatively.

RESULTS:

At 12 months postoperatively, there was a statistically significant improvement in visual and refractive outcomes (all
P
< .001). Mean UDVA improved to 0.17 ± 0.14 logMAR (vs 1.00 ± 0.38 logMAR preoperatively) and mean manifest refraction spherical equivalent improved to −0.32 ± 1.42 diopters (D) (vs −7.35 ± 5.20 D preoperatively). At 12 months, 63% of eyes achieved UDVA of 20/32 or better and 60.9% of eyes were within ±0.50 D of manifest refraction spherical equivalent. Mean refractive astigmatism improved from −2.90 ± 2.21 D preoperatively to −1.47 ± 1.46 D at postoperative 12 months (
P
< .001), with 30.4% and 45.7% of eyes having a postoperative astigmatic error within ±0.50 and ±1.00 D, respectively. No complications were observed.

CONCLUSIONS:
Toric ICL implantation was found to be safe and effective for the correction of myopia and myopic astigmatism in patients with stable keratoconus who had undergone TG-PRK+CXL, as revealed by the statistically significant improvement in visual and refractive outcomes at 12 months after toric ICL implantation.

[
J Refract Surg
. 2021;37(12):824–829.]
Erros e incidentes de medicaçao na atençao primaria: revisão integrativa
Authors: Soares Santos Anna Cecília , Grou Volpe Cris Renata , Moura Pinho Diana Lúcia , Roberta Silva Araújo Paula , Talita Adriano da Silva Heloiza 
Published: December 2021

Objetivo: Identificar, na literatura científica, publicações acerca dos erros de medicação e os incidentes relacionados, na atenção primária à saúde.
Método: Realizou-se uma revisão integrativa da literatura nas bases de dados Medical Literature Analysis and Retrieval System on Line, Cumulative Index to Nursing and Allied Health Literature, Scientific Eletronic Library Online e Web of Science. Analisaram-se 17 artigos que atenderam aos critérios de inclusão. Para extração dos dados, fez-se a leitura, na íntegra, dos artigos selecionados.
Resultados: dos 17 estudos analisados, sete (41,17%) foram indexados, tanto no PubMed, quanto no Medline; nove (52,94%) na Web of Science; um (5,9%) na base Scielo; e nenhum na Cinahl. Os estudos apontam fortes evidências na aplicação clínica, sendo que a maioria desses mostra que prescrições com medicamento incorreto, dose incorreta, interações medicamentosas e alergias medicamentosas foram as principais causas de erros com potencial para danos graves.
Conclusão: Ainda é crescente o desenvolvimento de pesquisas que visem identificar estratégias e intervenções voltadas aos erros de medicação. Sabe-se que esses estudos fornecem subsídios para o aprimoramento das práticas, além de propiciar maior segurança no processo de medicação, a fim de reduzir os eventos adversos evitáveis.
Subacute combined degeneration of spinal cord, optic atrophy and thrombocytopenia without anemia secondary to B12 deficiency
Authors: Perera Charith , Sivagnanam F. G. , Ranaweera Y. , Wijesooriya S. 
Published: December 2021

Long-standing vitamin B12 deficiency can lead to neurological manifestations such as optic atrophy and subacute combined degeneration of the cord without causing significant anemia. In addition, folic acid supplementation could mask the hematological manifestations of vitamin B12 deficiency and delay the presentation of neurological manifestations We present a case of a 32-year-old vegan woman on long-term sodium valproate and folic acid treatment presenting with progressive weakness of bilateral lower limbs for three months and reduced vision in both eyes for two weeks duration. Further evaluation revealed optic atrophy, combined degeneration of the spinal cord, macrocytosis, thrombocytopenia, and severely deficient serum B12 levels. With B12 replacement therapy, the patient’s overall wellbeing improved.
Comparison between Intravenous Dexmedetomidine and Spray as you Go with 4% Lignocaine Versus Intravenous Fentanyl and Transtracheal Injection of 4% Lignocaine for Awake Nasotracheal Intubation with Flexible Vedioscope – A Randomized Single-Blind Prospective Study
Authors: Kumar Miriyala Pavan , Patro Madhusmita , Panigrahy Sasmita , Samal Soumya , Kartheek B. Sai 
Published: December 2021

Background:
Awake fiber-optic bronchoscopy-guided intubation is the method of choice in difficult airway which requires effective airway anesthesia to ensure patient comfort and acceptance.

Aims:
This study was conducted to assess the quality of airway anesthesia, patient comfort during intubation, and postoperative satisfaction of patients.

Settings:
Patients posted for surgeries under general anesthesia with Mallampati Grade I and II in a medical college. Patients were followed in the operation theater and postoperative ward.

Study Design:
This was a prospective randomized single-blind study.

Materials and Methods:
Group D received intravenous (i.v.) dexmedetomidine 1 μg.kg−1 i.v. over 10 min and 3 ml of 4% lignocaine spray as you go (SAYGo). Group F received i.v. fentanyl 2 μg.kg−1 over 10 min and transtracheal injection 3 ml of 4% lignocaine. Parameters assessed were endoscopic time, intubating condition, vocal cord position, cough severity, comfort during intubation, postoperative patient satisfaction, and any adverse effects such as sore throat, hoarseness, unpleasant memories, and hemodynamic response during intubation.

Statistical Analysis:
Independent Student's t-test, Mann–Whitney, Chi-squared test, or Fisher's exact test were used. P ≤ 0.05 was considered statistically significant.

Results:
Intubating conditions, vocal cord position, cough severity, comfort during intubation, and postoperative patient satisfaction were statistically significant (P ≤ 0.05) in favor of Group D though endoscopic time was longer.

Conclusion:
IV dexmedetomidine with SAYGo is effective than IV fentanyl with transtracheal block for awake fiber-optic videoscopic intubation in terms of intubating conditions, vocal cord position, cough severity, comfort during intubation, and postoperative satisfaction of patients with significant attenuation of postintubation hemodynamic response and better preservation of respiration though endoscopic time is more.
Analyses of serum 25-hydroxyvitamin D levels and single nucleotide polymorphisms in the vitamin D receptor gene for acne vulgaris
Authors: Hassan M Mohammed , Shaker Olfat G. , Abd el-Raheem Talal A. , Yasen Sara M. 
Published: December 2021

Background
Acne vulgaris (AV) is one of the diseases that are widespread in Egypt. It is a disease that mainly affects the pilosebaceous units of the face, neck, and others.

Aim
To analyze and assess the role of 25-hydroxyvitamin D levels in serum as well as different vitamin D receptor (VDR) genes (Taq-1, Apa-1, Fok-1, and Cdx-2 polymorphisms) among Egyptian patients having AV.

Patients and methods
A total of 300 patients with acne and another 300 healthy controls were included in the study. Patients were subdivided into four different groups: group 1 received cholecalciferol 8000 IU/day for 3 months; group 2 applied 1–2 g of topical vitamin D analog for 3 months, group 3 had no treatment, and lastly, group 4 included healthy controls. For all patients, skin manifestations were assessed. Serum 25(OH)3 D was measured in all participants before and after treatment. Different VDR gene polymorphisms were measured.

Results
Patients with acne showed a statistically significant decrease in serum 25(OH) D3 concentration than controls, with P value of 0.001. Regarding VDR polymorphisms (rs731236 for Taq-1, rs7975232 for Apa-1, rs2228570 for Fok-1, and rs11568820 Cdx-2 polymorphisms), the results revealed that there was a statistically significant difference between patients with acne and controls regarding Taq-1 and Apa-1 genotypes, with P values of 0.001 and 0.026, respectively, whereas regarding Fok-1 and Cdx-2 genotypes, the results revealed that there were no statistically significant differences between the studied patients and the controls (P=0.690 and 0.113, respectively).

Conclusion
Vitamin D and VDR polymorphisms (Taq-1, Apa-1, Fok-1, and Cdx-2) play important roles in AV.
Oxidant and antioxidant status in patients with female pattern hair loss with varying severity
Authors: Khattab Fathia M. , Al-Karamany Amira S. 
Published: December 2021

Background
Female pattern hair loss (FPHL), also known as female androgenic alopecia, is a common dermatological disorder with a multifactorial pathogenesis. Oxidative status has been implicated in the pathogenesis of several skin diseases, including FPHL.

Aim
This study was aimed to investigate the levels of oxidative stress biomarkers in patients with FPHL with varying severities.

Patients and methods
The study involved 56 patients with FPHL and 46 healthy controls. Diagnosis was based on clinical examination and trichoscopic evaluation. Patients were grouped into three subgroups as follows: mild, moderate, and extensive. Oxidative stress was examined by measuring plasma levels of catalase (CAT), superoxide dismutase, total antioxidant capacity, and malondialdehyde (MDA).

Results
Plasma levels of MDA in FPHL were significantly higher as compared with that of the controls, whereas activities of the antioxidant enzymes superoxide dismutase and CAT were lower. Moreover, total antioxidant capacity was also low in patients with FPHL as compared with that of the controls. Higher MDA levels in the extensive FPHL subgroup as compared with that of the mild and moderate subgroups were also observed. Furthermore, in the extensive FPHL subgroup, a significant negative correlation was observed between MDA and CAT levels.

Conclusion
The data suggest that oxidative stress plays a key role in FPHL progress, which accelerates hair loss by causing microinflammation and fibrosis. The recognition of the effect of androgens and associated factors on the hair follicle cycle is essential for the development of new and effective treatment methods and may be employed as a biomarker index to assess the disease’s activity and to monitor its treatment.
Therapeutic efficacy of three systemic antifungals in onychomycosis
Authors: Taha Emad A. , Moharam Ahmed Mohamed , Ladeed Amany Morgan , Tawfik Yasmin M. , Bakr Radwa M. 
Published: December 2021

Background
Onychomycosis is a nail fungal infection that significantly affects the patient’s quality of life. It represents a treatment challenge for dermatologists.

Aim
The aim was to compare the efficacy of pulse therapy of itraconazole, fluconazole, and terbinafine in the treatment of onychomycosis.

Patients and methods
Sixty patients clinically and mycologically diagnosed with onychomycosis were included in this study. Patients were randomly divided into three groups: group A received itraconazole (400 mg/day for 1 week/month); group B received fluconazole (300 mg/week); and group C received terbinafine (500 mg/day for 1 week/month). All patients received the treatment for 3 months and were followed up for another 3 months. They were evaluated clinically by photography, mycologically (microscopy and culture), and by the ‘Naildex score questionnaire’.

Results
The clinical, mycological, and complete cure rates were the highest among group A (80, 70, and 70%, respectively), followed by group C (60, 55, and 55%, respectively) and finally group B (50, 35, and 35%, respectively), with no statistical difference between them. Also, group A showed greater improvement in the nail function index compared with the other two groups.

Conclusion
Pulse therapy of itraconazole, terbinafine, or fluconazole was effective in the treatment of onychomycosis with increasing patient compliance. The best response was achieved with itraconazole, followed by terbinafine and finally fluconazole.
¿Emprendimiento o startup? Un análisis creativo en el contexto peruano
Authors: Lazarte Aguirre Andrea 
Published: December 2021

Las sociedades buscan iniciativas —como emprendimientos o startups— que aporten productos novedosos y originales como propuestas de valor sostenibles; sin embargo, en el Perú se ha identificado una confusión entre lo que significa un emprendimiento y una startup. Por ello, el trabajo consistió en evaluar el estado de estas definiciones, para lo cual se aplicó una metodología exploratoria basada en entrevistas a emprendedores del ecosistema peruano. El principal resultado demuestra que muchos de los actores diferencian un emprendimiento tradicional de una startup con base en variables como el crecimiento exponencial y el componente tecnológico. No obstante, no se evidencian la creatividad o la innovación como diferenciadores de la startup. Este trabajo se propone profundizar en estas nociones, a fin de potenciar al ecosistema emprendedor.

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Diseño centrado en el usuario para seleccionar tecnología para controlar las variables de preservación de documentos y obras antiguas (Caso de aplicación: Sistema de preservación de códices precolombinos)
Authors: González David Ibarra , Hernández David Joaquín Delgado 
Published: December 2021

Los mapas, planos, arte gráfico, arte plumario y en general toda obra histórica, requieren de cuidados especiales. Altos índices de temperatura y humedad, así como la presencia de gases oxidantes, polvo, vibración, golpes, radiación UV, además del desarrollo de hongos e insectos, entre otros, favorecen el proceso de degradación al producir daño a su estructura.
El diseño centrado en el usuario, al ser aplicado a temas de preservación y conservación, facilita estructurar sistemas adaptados a las condiciones particulares requeridas por la obra para mantenerla en las mejores condiciones posibles. Dichos sistemas permiten, principalmente, medir y mantener las variables de conservación.
El diseño centrado en el usuario permite al diseñador integrar los elementos involucrados para llegar a soluciones eficientes, que ayuden a los conservadores a decidir y poder ejecutar las medidas necesarias para la protección de obras históricas, de forma económica y con tecnología fácil de usar.
Providensia Allah di masa Pandemi Covid-19
Authors: Hermanto  , Harti Sri Dwi , Manu Charisal B.S. 
Published: December 2021

Abstract: The fall of man into sin, brings consequences and rewards that cannot be denied. In this case, man must bear the yoke of suffering caused by sin. Suffering will always be in touch wit human life, so that all humans cannot escape suffering. In the beginning, God made everyhting really very good, but human desires have polluted God’s created world. Thus, human disease and suffering, caused by humans themselves, include deadly parasites and viruses. However, God never abandons the work of His hands. The purpose of this research it is to remind and strengthen beleivers in particular, to keep standing firm on Jesus Christ who is the steadfast rock. Thus, beleivers are expected to continue to have faith in God’s providence, even in difficult times doe to the pandemic. The research method used is descriptive qualitative, with a library research data collection system through the help of books and related journal articles. In this study, it was found that even though humans are not faithful, God is still faithful to protect and care for creation. More than that, God through history demonstrated His sovereignty over the universe, namely through His foreknowledge of all things and made all things for His eternal purpose.
Abstrak: Kejatuhan manusia kedalam dosa, membawa konsekuensi serta upah yang tidak dapat ditolak. Dalam hal ini, manusia harus memikul kuk penderitaan akibat yang ditimbulkan oleh dosa. Penderitaan akan selalu bersentuhan dengan kehdidupan manusia, sehingga semua manusia tidak dapat luput dari pendertaan. Pada mulanya, Allah menjadikan segala sesuatu sungguh amat baik, tetapi keinginan manusia telah membuat dunia ciptaan Allah menjadi tercemar. Dengan demikian, penyakit serta penderitaan manusia, disebabkan oleh manusia itu sendiri, termasuk parasit serta virus yang mematikan. Meskipun demikian, Allah sekali-kali tidak meninggalkan perbuatan tangan-Nya (providensia). Adapun tujuan dari penelitian ini adalah untuk mengingatkan serta menguatkan orang percaya secara khusus, untuk tetap berdiri teguh pada Yesus Kristus yang adalah batu karang yang teguh itu. Dengan demikian, orang percaya diharapkan tetap beriman pada pemeliharaan Allah, sekalipun di masa sulit akibat Pandemi. Adapun metode penelitian yang digunakan adalah kualitatif deskriptif, dengan sistem pengumpulan data library research melalui bantuan buku-buku serta artikel jurnal yang terkait. Dalam penelitian ini, ditemukan fakta bahwa sekalipun manusia tidak setia, Allah tetap setia untuk menjaga dan memelihara ciptaan. Lebih dari itu, Allah melalui sejarah menunjukkan kedaulatan-Nya atas alam semesta, yakni melalui pra-pengetahuan-Nya atas segala sesuatu dan menjadikan segala sesuatu untuk tujuan kekal-Nya.