bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable and Efficient Processing of Gh4169 Superalloy With Rotating Short Arc Milling Method
Authors: Zhang Jin , Han Fuzhu 
Published: May 2021

Abstract
High processing efficiency and low environmental pollution have been recognized as important goals of sustainable electrical discharge machining (EDM). This paper proposed a sustainable and efficient EDM method called rotating short arc milling. In order to improve the processing efficiency and reduce pollutant emissions, the principles of this method to achieve high material removal rate (MRR), low tool electrode wear rate (TEWR) and environmentally friendly dielectric are described separately. The rotating short arcs generated by the compound field can improve the machining efficiency. The action of the magnetic field and the internal high-pressure dielectric can quickly remove the debris avoiding irregular discharge, thereby improving the machining quality. Due to the attraction effect of the magnetic field on the debris, several debris adhere to the processing end of the tool electrode to form a protective layer and participates in the processing as a part of the tool electrode, which can reduce the tool electrode wear. Tap water is used as the working fluid to reduce pollutants generated during processing. Then, a series of experiments are conducted to study the influence of process parameters on the processing of GH4169 superalloy. The results show that the machining voltage, machining depth and magnetic field strength are the three most important factors that affect the efficiency and sustainability of rotating short arc milling. Furthermore, the optimal process parameters are obtained by using gray relational analysis method to optimize the machining process in terms of high efficiency and environmental protection.
Effect of K2O/ZnO+CaO Ratio on Density, Glass Forming Ability, Crystallization of SiO2- Al2O3- ZnO- K2O- CaO Frites
Authors: faghinia aida , Salami R. , Khakpour Z. , Zakeri M. 
Published: May 2021

Abstract
The frites by mole fraction of 2.5 SiO2, 0.20 Al2O3, 0.15 B2O3, 0.15ZnO, 0.17K2O, 0.67CaO systems in three ratios of S including 0.37(denoted by F1frites ),0.31(F2), 0.24(F3) (S=K2O/CaO+ZnO) were studied. ZnO powder with 500 nm (N series) and >1μm sizes (F series) opted from the recycled Zn ingots dusts and commercially ZnO respectively, were used as the raw materials. By decreasing the S ratio, the Molar Volumes of frites were decreased, The glass transition ΔTg(=-154ºC), and the crystallization temperatures ΔTp (=+17ºC) values were decreased and increased respectively. It was shown that the GS (glass stability) values are independent of the Zinc Oxide's powder size, while the Molar Volumes of N series were lower than the F ones. The Zinc Silicate (Willemite) beside Anorthite and Parawollastonite phases were crystallized in the resulted glazes. The hardness values were in 700-850 Hv range, the transparency and whiteness were higher than 80 and 60 respectively.
ApoE-TREM2 axis induces pathogenic senescent-like myeloid cells in prostate cancer
Authors: Calcinotto Arianna , Bancaro Nicolò , Troiani Martina , Arzola Rydell , Elia Angela Rita , Attanasio Giuseppe , Calì Bianca , Crespo Mateus , Gurel Bora , Pereira Rita , Guo Christina , Mosole Simone , d’Ambrosio Mariantonietta , Pasquini Emiliano , Spataro Clarissa , Zagato Elena , Rinaldi Andrea , Lascio Simona Di , Meani Francesco , Mestre Ricardo Pereira , Bolis Marco , Montopoli Monica , De Bono Johann , Alimonti Andrea 
Published: May 2021

Abstract
The authors have requested that this preprint be removed from Research Square.
Research on Body Positioning Measurement Method of Bolting Robot based on Vision Theory
Authors: Hao Xuedi , Yang Xueqiang , Zhang Jinglin , Ding Yaotian , Wu Miao 
Published: May 2021

Abstract
In view of the intelligent demand of underground roadway support and the precise positioning of underground unmanned fully mechanized face, a method of body positioning measurement of bolting robot based on the principle of monocular vision is proposed. In this paper, a vehicle body positioning model based on image data is established. The data is obtained by camera, and the transformation between image coordinates and world coordinates is completed by coordinate system transformation. The monocular vision positioning system of bolting robot is designed, and the simulation experimental model is built to measure the effective positioning distance of monocular vision positioning system in the simulation experimental conditions. The experimental platform of bolting robot is designed, and the vehicle is measured Real time data of body positioning, analysis of experimental error and demonstration of reliability of the method. In this method, the real-time localization of underground mine is realized by the robot of bolting, and the accuracy and efficiency of localization are improved, which lays the foundation for the localization control of mining face and the automation and unmanned of the robot of bolting.
Factor VII Deficiency and Pregnancy: A Case Report and Review of Literature
Authors: Rohilla Minakshi , Rai Rakhi , Ahluwalia Jasmina , Malhotra Pankaj , Jain Vanita 
Published: May 2021

Abstract
Inherited factor VII deficiency is an autosomal recessive coagulation disorder with broad range of bleeding manifestations. The association between bleeding and absolute factor VII level is poor. Usually, the bleeding is associated with FVII levels of less than 1% of the normal value. Factor VII deficiency is associated with prolongation of prothrombin time only with normal activated partial thromboplastin time. Approximately 66 pregnant women have been reported with factor VII deficiency so far in English literature. We hereby, report 2 cases along with the review of literature of Factor VII deficiency during pregnancy. Our patients were diagnosed to have factor VII deficiency after deranged coagulogram with factor VII level of < 1% and 17.1% respectively, however could be managed by fresh frozen plasma only in first case and fresh frozen plasma & factor VII concentrate in second case successfully. Coagulogram is a simple, easily available, affordable and lifesaving investigation to detect this deficiency in pregnancy.
Management of Fibroids Prior to in Vitro Fertilization. Case Reports
Authors: Gastañaga-Holguera Teresa , González Virginia González , Urrutia Marta Calvo , Gesto Isabel Campo , Lázaro Marta Vidaurreta , García Ignacio Cristóbal 
Published: May 2021

Abstract
BACKGROUND. Uterine fibroids are common benign uterine neoplasms in women in reproductive age and pregnancy desire. Several surgical approaches for symptomatic fibroids are available, such as surgical or pharmacologic treatments. We report three cases of fibroids treatment in women with primary sterility. CASE PRESENTATION. The first case of a successful in vitro fertilization (IVF) after ulipristal acetate (UPA) as an alternative treatment to reduce the fibroids size in a patient with two previous abdominal myomectomies, resulting in an evolutive pregnancy. The second patient underwent several myomectomies (both abdominal and hysteroscopic) in a long period of time. And the third one of a successful IVF after UPA in a patient with a submucous fibroid which induced myoma migration leading to its prolapse.CONCLUSIONS. Myomectomy appears to be the gold standard treatment for fibroids in women with reproductive desires. Nevertheless, more series are essential for establishing the safety of UPA as a treatment of symptomatic fibroids prior to pregnancy.
Bone Marrow Hyperplasia in Elderly Acute Lymphoblastic Leukemia Changed From Low Into Hyperactive: a Case Report
Authors: Zhang Bin , Cai Yan-Xia , Wang Xia , Liu Xun-Tao , Fang Sheng-Chun , Zhang Su-Zhen , Zhao Fei , Guo Di-Yuan , Geng Li-Na 
Published: May 2021

Abstract
Background: To retrospectively reported a case of bone marrow hyperplasia in elderly acute lymphoblastic leukemia changed from low into hyperactive, in order to improve the understanding of this disease. Case presentation: We continuously followed up a patient of bone marrow hypoplastic patients by evaluating his clinical results, bone marrow morphology and flow cytometry, and analyzing the results at different locations in two consecutive bone marrow punctures. The patient’s hypoplastic bone marrow suddenly became extremely hyperplasia. Before this change, there was early-stage alterations in morphology, flow cytometry and biopsy of the bone marrow, but there was no significant change in peripheral blood cells.Conclusions: For patients whose hypoplastic bone marrow suddenly became extremely hyperplasia, morphology was not very useful, thus definite diagnosis must be dependent on immunological types and bone marrow biopsy results.
Riedel's Thyroiditis Within an Elderly Patient Revealed by Tracheal Compression: a Case Report
Authors: Traore Zie Cheick ahmed , N'Guiessan Alphonse Aman , Coulibaly Zana Ismael , Koffi Kouadio Donatien , Toure Ibrahiman , Kouyate Mohamed 
Published: May 2021

Abstract
Background : Riedel's thyroiditis (RT) is a rare fibrosclerotic disease that affects the thyroid gland and surrounding tissues. The etiology is unknown, and it rarely affects the elderly.Case Presentation : A 56-year-old man, with no particular medical history, was seen in consultation at the Surgery Department of the Treichville Teaching University Hospital for a painless swelling of the anterior base of the neck. Physical examination showed a patient with inspiratory dyspnea probably due to tracheal compression. The patient underwent a subtotal thyroidectomy because of the clinical symptomatology and the persistence of dyspnea. Macroscopically, the thyroid mass was well-encapsulated, weighed 80g, and measured 10 cm x 5 cm x 2 cm. After section, we observed whitish fibrous nodules associated with pinkish-brownish band. Histologically, the architecture of thyroid tissue was restructured by dense and diffuse collagenous fibrosis in which rare atrophic thyroid vesicles were found. The fibrous areas were infiltrated by inflammatory elements, including lymphocytes, plasmocytes, and eosinophilic polynuclear cells. No malignant cells were found. Masson's trichrome staining confirmed the fibrous nature of the thyroid tissue, which is essential for the certain diagnosis of Riedel's thyroiditis. There was no postoperative complication Conclusion : Riedel's thyroiditis is a rare disease that is difficult to diagnose preoperatively despite advances in imaging and fine needle cytology screening methods. Histological examination of the sample confirms the diagnosis of Riedel's thyroiditis. Thyroidectomy is indicated in patients with compression symptoms. Clinicians should suspect Riedel's thyroiditis in patients with a hard thyroid mass with compressive symptoms, despite its rarity.
Pulmonary Tumor With Notochordal Differentiation: A Case Report and Morphologic, Immunohistochemical and Molecular Study of Benign Notochordal Cell Tumor Originating in the Lung
Authors: Song Kai , Ma Xiaojing , Xu Jinghong , Chen Lirong 
Published: May 2021

Abstract
Background: Extraosseous benign notochordal cell tumor is extremely rare, and there are only five reported cases worldwide. The presented case of pulmonary primary benign notochordal cell tumor is the sixth case, but the first to report the deletion mutation of EGFR gene exon 19. Case presentation: The patient was a 50-year-old asymptomatic woman, who had been followed up for 3 years for a nodule in the right lung. Six months after the wedge resection, the patient is alive without evidence recurrence or metastasis. The tumor was 7 millimeters in diameter and was well demarcated. The tumor was consisted of a sheet of large round vacuolated cells with small and bland nuclei. No connective tissue containing blood vessels or inflammatory cell infiltration was detected in the ﻿stroma. The tumor were positive for CK AE1/AE3, Vimentin, S100 and Brachyury. Deletion mutation of EGFR gene exon 19 was first detected and reported. Conclusions: We firstly reported the EGFR mutation of pulmonary primary benign notochordal cell tumor. Due to the rarity of this tumor, more reports are need to explore pathological characteristics, especially the molecular characteristics, in order to better understand the nature of tumors
Identification of CCNB2 expression in triple-negative breast cancer based on bioinformatics results
Authors: cao jintao , SUN SHUAI , LI RAN , MIN RUI , FAN XINGYU , HAN YUEXING , FENG ZHENZHONG , LI NAN 
Published: May 2021

Abstract
Background

The current epidemiology shows that the incidence of breast cancer is increasing year by year and tends to be younger. Triple-negative breast cancer is the most malignant of breast cancer subtypes. The application of bioinformatics in tumor research is becoming more and more extensive. This study provided research ideas and basis for exploring the potential targets of gene therapy for triple-negative breast cancer (TNBC).
Methods

We analyzed three gene expression profiles (GSE64790、GSE62931、GSE38959) selected from the Gene Expression Omnibus (GEO) database. The GEO2R online analysis tool was used to screen for differentially expressed genes (DEGs) between TNBC and normal tissues. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were applied to identify the pathways and functional annotation of DEGs. Protein–protein interaction network of these DEGs were visualized by the Metascape gene-list analysis tool so that we could find the protein complex containing the core genes. Subsequently, we investigated the transcriptional data of the core genes in patients with breast cancer from the Oncomine database. Moreover, the online Kaplan–Meier plotter survival analysis tool was used to evaluate the prognostic value of core genes expression in TNBC patients. Finally, immunohistochemistry (IHC) was used to evaluated the expression level and subcellular localization of CCNB2 on TNBC tissues.
Results

A total of 66 DEGs were identified, including 33 up-regulated genes and 33 down-regulated genes. Among them, a potential protein complex containing five core genes was screened out. The high expression of these core genes was correlated to the poor prognosis of patients suffering breast cancer, especially the overexpression of CCNB2. CCNB2 protein positively expressed in the cytoplasm, and its expression in triple-negative breast cancer tissues was significantly higher than that in adjacent tissues.
Conclusions

CCNB2 may play a crucial role in the development of TNBC and has the potential as a prognostic biomarker of TNBC.
Primitive myxoid mesenchymal tumor of infancy in scrotum: A case report and literature review
Authors: Li Chunsen , Wang Mengqiao , Dang Hongwei , Pan Yan , Liu Yi , Zhao Haiou , Liu Chunxia 
Published: May 2021

Abstract
BackgroundPrimitive myxoid mesenchymal tumor of infancy (PMMTI) is a rare tumor and its molecular mechanism and prognosis remain unclear. We here report a case of PMMTI, and review the reported literature of PMMTI.Case presentationA one-year-old boy found a lump in his right groin. The size of the mass was 1 cm×1 cm. Computed tomography showed a round, slightly dense shadow of 38 mm×32 mm in the right groin. The tumor was removed for pathological examination, and the size of the tumor was 6.0 cm×5.0 cm×3.0 cm. Tumor cells are diffusely distributed, mainly spindle cells. The blood vessels were abundant, many adipocytes can be observed in some areas, and focal lymphocyte infiltration can be seen in a few areas. Immunophenotype was as follows: histone H3 at lysine 27 (H3K27me3), B-cell lymphoma 6 corepressor (BCOR) and Bcl-2 were positive, cluster of differentiation 99 (CD99) showed diffuse reactivity, BCL6 was scattered positive, Ki-67 proliferation index was 20%. Dual-color fluorescence in situ hybridization (FISH) showed red and green signal nuclei caused by the deletion of ETV6 gene rearrangement. The patient underwent extensive surgical resection during the recurrence period and was in good condition 7 months later.ConclusionsPMMTI is at least a low-grade malignancy. BCOR, BCL2, BCL6, and CD99 can be used as special IHC markers, and most PMMTI cases exhibit BCOR ITD change. H3K27me3 may be used as a new IHC marker for PMMTI.
Knockdown circ_0040414 inhibited inflammatory, apoptosis and promoted proliferation of cardiomyocyte via miR-186/PTEN/AKT pathway in chronic heart failure
Authors: Feng Yanling , Cheng Hongji , Wu Jinlei , Chen Qinxiu , Duan Yuexing , Zhang Peng , Zheng Dong , Lin Guixiong , zhuo yufeng 
Published: May 2021

Abstract
Background

Previous studies have found that the expression of circ_0040414 is elevated in heart failure (HF) patients, but the role and mechanism of circ_0040414 in HF are not yet known. The purpose of this study is to clarify the role of circ_0040414 in chronic HF (CHF) and its potential mechanism for regulating the progression of CHF.
Methods

Peripheral blood samples of patients with chronic heart failure and normal people were collected to detect the expression difference of circ_0040414; ROC curve was made to evaluate the value of circ_0040414 in the diagnosis of CHF; CCK8 method was implemented to detect the speed of cell proliferation; flow cytometry was performed to detect the degree of cell apoptosis; ELISA assay was used to detect the inflammatory cytokines IL-6, TNF-α and IL-β secreted by cells; circinteractome and starbase databases were used to analyze the downstream target molecules of circ_0040414 and miR-186, respectively; RT-qPCR and western blot were implemented to evaluate the expression levels of RNA and protein, respectively.
Results

We found that the expression of circ_00404141 in the peripheral blood of CHF patients is significantly higher than that of normal people, and it has a high diagnostic value for CHF. Circ_00404141 promotes cardiomyocyte apoptosis and inflammation, while inhibiting the proliferation of cardiomyocytes. In terms of mechanism, circ_00404141 promotes the expression of Phosphatase and Tensin Homolog (PTEN) through sponge miR-186 and inhibits AKT signal activity.
Conclusion

We clarified that silencing circ_00404141 promotes cardiomyocyte proliferation through miR-186/PTEN/AKT signal axis, inhibits cell apoptosis and inflammation.
Everolimus Release Mechanism from Magnesium alloy Based Bioabsorbable Nanohybrid Coronary Stent
Authors: Sadeghabadi Asghar , Sadrnezhaad Seyed Khatiboleslam , Asefnejhad Azadeh , Nemati Nahid Hassanzadeh 
Published: May 2021

Abstract
The impact of magnesium degradation on Everolimus release from WE43/PLLA nano-hybrid stent was compared with cobalt-chromium L605 alloy. Effect of Mg degradation on drug release from WE43/PLLA was much higher than from L605/PLLA. SEM, UV-VIS, FTIR, pH measurement, and H₂ evolution tests determined the hybrids’ property-change and drug release rate. Hydrogen evolution caused by magnesium degradation compelled Everolimus out without significant PLLA decomposition during the first 100 days, while formation caused PLLA shape change and cracking. A combined lattice/hole diffusion-dissolution mechanism governed the Everolimus release with the activation energies of 5.409 kJ/mol and 4.936 kJ/mol for the first 24 h and diffusion coefficients 6.06 x 10-10and 3.64 x 10-11 cm2/s for the 50th to 100th days. The prolonged suppression of the hyperplasia within the smooth muscle cells by hybrid stent insertion could bring about restenosis cessation. As a result, implanting magnesium alloy stent in patients suffering from coronary artery problems and COVID19 can be more useful than current stents.
The risk factors of under-five deaths in rural parts of Ethiopia
Authors: Mihret Yenew Alemu 
Published: May 2021

Abstract
Background of the study: Under-five mortality is the likelihood for a child born alive to die between birth and fifth birth day. Mortality under the age of five has been the main problem in public health policies especially in rural parts of Ethiopia.Objective: The objective of this study was to assess the risk factors of under-five mortality in Ethiopia using the 2011 EDHS data. Results: Information from 8,668 women included in the study show that 64.5% of the women never experienced under-five deaths of their children. Among four possible count models considered, the ZINB regression model was selected as the most appropriate model. Conclusion: The study revealed that mother’s age first birth, breastfeeding status, wealth index, whether the mother is currently working, region and mother’s level of education had statistically significant association with the number of under-five deaths in rural parts of Ethiopia.
Intrusion Induced Global Warming Preceding Continental Flood Basalt Volcanism
Authors: Tian Xiaochuan , Buck W 
Published: May 2021

Abstract
Temporal correlations between continental flood basalt eruptions and mass extinctions are well known 1. Massive carbon degassing from volcanism of Large Igneous Provinces can cause catastrophic global climatic and biotic perturbations 1–3. However, recent more accurate dating of the Deccan Traps 4 and Columbia River Basalts 5 challenges this causal link by showing that global warming preceded the major phase of flood basalts eruptions by several hundred thousand years. Here, we argue that major eruptions of continental flood basalts may require densification of the crust by intrusion of larger volumes of magma than are extruded. Simple models show that magma crystallization and release of CO2 from such intrusions could produce global warming before the main phase of flood basalt eruptions on the observed timescale. Being consistent with many geological, geophysical, geochemical and paleoclimate data, our model suggests that the evolving crustal density has a first order control on timing of the major phase of continental flood basalt volcanism while the preceding intrusion induced underground degassing of CO2 plays a significant role in controlling the Earth's climate and habitability.