bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of blood pressure on post stroke cognitive impairment: BP and PSCI
Authors: Wang Yue , Li Shiping , Pan Yuesong , Wang Mengxing , Liao Xiaoling , Shi Jiong , Wang Yongjun 
Published: November 2021

AbstractCognitive function following acute ischemic stroke (AIS) is critical to prognosis and quality of life. Hypertension is a risk factor for stroke and is associated with post stroke cognitive impairment (PSCI). However, the optimal blood pressure parameters after AIS is unknown. This is a sub‐study of the Impairment of CognitiON and Sleep after acute ischemic stroke or transient ischemic attack in Chinese patients (ICONS) study conducted between August 2015 and March 2018. Cognition was assessed at two‐week (2w), three‐month (3 m), and twelve‐month (12 m) by Montreal Cognitive Assessment (MoCA). A total of 682 participants who met the inclusion criteria were enrolled. The primary outcome was cognitive changes after 3 and 12 months post stroke. Among 682 participants, the mean age was 59.35 ± 10.40 years and 72.29% were men. PSCI patients with high systolic blood pressure (SBP ≥140 mm Hg) at 3 m not only had worse cognition as evidenced by MoCA scores at 3 m but also predicted worse scores at 12 m. When participants were stratified into cognitively stable/improved (MoCA score ≥0, 2w vs. 12 m) and cognitively impaired (MoCA score ≤‐2, 2w vs. 12 m), those with high SBP were more likely to be cognitively impaired (OR 2.17, 95%CI 1.12–4.21, p < .05) and less likely to be cognitively stable/improved (OR 0.66, 95%CI 0.44–0.99, p < .05). SBP more than 140 mm Hg is associated with worse cognitive performance after ischemic stroke. Patients with SBP lower than 140 mm Hg have better cognitive outcome at 3‐month and 1 year after stroke.
miR‐4431 targets TRIP10/PRKD1 and impairs glucose metabolism
Authors: Pan Chongge , Li Menghuan , Wang Jingzhou , Chu Xiaolong , Xiong Jianyu , Yang Xin , Tang Yihan , Ma Dingling , Yuan Chenggang , Zhu Jiaojiao , Chang Yongsheng , Zhang Jun , Wang Cuizhe 
Published: November 2021

AbstractAim/IntroductionObesity is considered an important risk factor for many metabolic disorders, especially type 2 diabetes mellitus, and microRNAs (miRNAs) play a vital role in the development of type 2 diabetes mellitus. Therefore, we conducted this study to investigate the role of miR‐4431 in the obesity‐associated pathobiology of type 2 diabetes mellitus.Materials and methodsSubjects were divided into normal control (n = 36), obese (n = 36), and type 2 diabetes mellitus (n = 12) groups, and serum miR‐4431 levels were analyzed. Adenovirus‐vectored miR‐4431 mimic or sponge was intraperitoneally injected into the normal diet group and the high‐fat diet group (HFD) mice to investigate glucose tolerance, insulin sensitivity, and lipid levels. The downstream target genes of miR‐4431 were predicted using bioinformatics, and they were verified in vitro.ResultsSerum miR‐4431 levels were significantly high in obese and type 2 diabetes mellitus individuals, and positively correlated with the body mass index and fasting plasma glucose levels. In HFD mice, miR‐4431 levels in the serum, white adipose tissue, and liver were significantly increased. Moreover, miR‐4431 impaired glucose tolerance, insulin sensitivity, and lipid metabolism in mice. Bioinformatic prediction suggested that TRIP10 and PRKD1 could be the downstream target genes of miR‐4431. The HFD mice showed a remarkable reduction in the mRNA levels of TRIP10 and PRKD1 in the liver, which were countered by blocking miR‐4431. In HepG2 and L02 cells, miR‐4431 could downregulate TRIP10 and PRKD1 while blocking glucose uptake. The luciferase reporter assay showed that miR‐4431 could bind TRIP10 and PRKD1 3′‐UTR.ConclusionmiR‐4431 targets TRIP10/PRKD1 and impairs glucose metabolism.
The effects of short‐term heat stress on functional response ofNeoseiulus barkeritoTetranychus urticae
Authors: Li Wei‐Zhen , Zhu Tong , Li Hao‐Long , Shang Su‐Qin 
Published: November 2021

AbstractThe predatory miteNeoseiulus barkeri(Acari: Phytoseiidae) is typically used for biocontrol ofTetranychus urticaeon strawberries. However, its biological characteristics are greatly affected by temperature in hot summer days. In this study, the influence of different short‐term heat stresses on the functional response and prey consumption of unmated female ofN. barkerion three stages (egg, protonymph and adult) ofT. urticaewas evaluated. Three temperatures (38, 40 and 42°C), three short‐term heat duration (2, 4 and 6 hr), eight prey densities (3, 6, 9, 12, 15, 18, 21 and 24 individuals), (85 ± 5) % RH and a 16‐hr: 8‐hr (L:D) photoperiod were used during a 24‐hr period in functional response experiments. The results showed that the eggs ofN. barkericould not hatch at 42°C and the type II functional response was determined for adult females ofN. barkeriat all treatments by using the logistic regression analysis. TheN. barkerihad the highest attack rate of 1.029, 2.044 and 0.913 hr‐1for three stages ofT. urticaeat 25°C and the lowest value of 0.585, 0.973 and 0.498 hr‐1at 40°C, 6 hr. On the contrary, the handling time of the predator prolonged when the temperature increased from 25°C to 40°C and the maximum level was observed at 40°C, 6 hr (0.126, 0.153 and 0.172 hr). Our study indicated that the effects of short‐term heat stress were negative on the predation ability ofN. barkeriand heat stress should be avoided as much as possible to achieve the best predation and control effect ofN. barkeriin indoor rearing and field release.
Does Gross or Net Debt Matter More for Emerging Market Spreads?
Authors: HADZI‐VASKOV METODIJ , RICCI LUCA ANTONIO 
Published: November 2021

AbstractDoes gross or net debt matter for long‐term sovereign spreads in emerging markets? The topic is important for understanding the borrowing cost implications of public asset–liability management decisions (e.g., using assets to lower debt). We investigate this question using data on emerging market economies (EMEs) over the period 1998–2014. We find that both gross debt and assets have a significant impact on long‐term sovereign bond spreads in emerging markets, with effects roughly offsetting each other (coefficients of opposite sign and similar magnitude). Hence, net debt seems more appropriate than gross debt when evaluating the impact of indebtedness on spreads. The empirical results suggest that an increase in net debt by 10 percentage points of GDP implies an increase in the spread by 100–120 basis points, and the effect is larger during periods of domestic distress. The key results from this empirical study are quite robust to alternative specifications and subgroups of EMEs.
How are Competing Logics Combined in Managerial Teams? The Impact of Branch Founding Team Hybridity on the Growth of Islamic Bank Branches in Turkey, 2002–19
Authors: Boone Christophe , Özcan Serden , Li Jia 
Published: November 2021

AbstractHybrid staffing – i.e., composing a workforce with individuals with oppositional institutional logics – is a strategy organizations can use to navigate through complex institutional environments. We propose that hybrid teams led by individuals with the legitimate logic from the perspective of the target audiences (conformist‐led hybrids) will outperform all‐conformist, non‐hybrid teams, and that hybrid teams led by individuals with the contested logic (alien‐led hybrids) will underperform non‐hybrid teams. Moreover, the performance advantage of conformist‐led hybrids will be attenuated by ideological polarization and demographic stability of the embedding community, and the performance disadvantage of alien‐led hybrids will be exacerbated by these two community characteristics. We tested our multilevel contingency model with the newly founded Islamic bank branches in Turkey in 2002–19. We found that the conformist‐led hybrids had a growth advantage over non‐hybrids, and alien‐led hybrids had a growth disadvantage, especially when the embedding communities were ideologically polarized. Theoretical implications are discussed.
Evaluation by polymerase chain reaction assay of persistent shedding of pathogenic leptospires in the urine of dogs with leptospirosis
Authors: Hetrick Katie , Harkin Kenneth R. , Peddireddi Lalitha , Henningson Jamie 
Published: November 2021

AbstractBackgroundPersistent leptospiruria in naturally infected dogs occurs despite appropriate antibiotic treatment.Hypothesis/ObjectivesTo determine the frequency of persistent leptospiruria in naturally infected dogs and the association of persistent leptospiruria with different antibiotic treatments.AnimalsThirty‐two dogs of varying age and breed diagnosed with leptospirosis via urine polymerase chain reaction assay (PCR).MethodsA prospective observational study of dogs diagnosed with leptospirosis was undertaken to determine the frequency of persistent leptospiruria as determined by PCR. Clinical presentation of leptospirosis, antibiotic treatment, serum creatinine concentration, and outcome were recorded.ResultsFifteen of 32 dogs had a negative urine PCR on the first submission in the study, 5 of 15 received only an aminopenicillin. The remaining 17 dogs had a negative urine PCR on the second (n = 6 dogs), third (n = 5), fourth (n = 5), and eighth (n = 1) submissions. Acute kidney injury was reported in 32/32 dogs. Two of 32 dogs developed chronic kidney disease.Conclusions and Clinical ImportancePersistent leptospiruria is common despite treatment with antibiotics frequently recommended for treatment. Follow‐up urine PCR to confirm clearance of the organism is recommended in all dogs. In dogs with persistent leptospiruria, chronic kidney disease can develop after acute kidney injury.
Definition of “fairy circles” and how they differ from other common vegetation gaps and plant rings
Authors: Getzin Stephan , Yizhaq Hezi , Tschinkel Walter R. 
Published: November 2021

AbstractAimsThe fairy circles along the Namib Desert in southern Africa are round grassland gaps that have puzzled scientists for about 50 years. With the discovery of fairy circles in Australia in 2016, the debate on the origin of the circles has been extended to a new continent. Research interest on the topic has since then risen strongly but so has the use of the term “fairy circle”. This term has become more imprecise and, by analogy, has been applied to circular vegetation gaps or plant rings that are largely unrelated to fairy circles. For this reason, we define the concept of fairy circles by identifying their three main characteristics based on in situ field observations and soil excavations to larger‐scale spatial patterns, and regional‐scale distribution.ResultsFollowing this approach, fairy circles are defined by: (a) being “empty gaps” in grassland without a central insect‐nest structure; (b) their ability to form spatially periodic patterns, which are regular hexagonal patterns with an extraordinary degree of spatial ordering; and (c) their strongly regional distribution confined within a narrow arid climatic envelope. In these combined traits, fairy circles differ from other common vegetation gaps which, for example, always have a central insect‐nest structure and may occur across broad climatic gradients on continents. Also plant rings have their own specific characteristics that largely differ from the combined attributes of genuine fairy circles.ConclusionsThere are many other vegetation‐gap patterns in arid lands but if such gaps cannot jointly show the three characteristics defining the fairy circles, they should be carefully discussed on their own, rather than mixing them up with fairy circles. Our synthesis provides a new etymology for the different types of vegetation gaps and rings, aiming to guide the reader through various classes of circular plant patterns.
Glycosylated 4‐methylumbelliferone as a targeted therapy for hepatocellular carcinoma
Authors: Weiz Gisela , Molejon Maria I. , Malvicini Mariana , Sukowati Caecilia H. C. , Tiribelli Claudio , Mazzolini Guillermo , Breccia Javier D. 
Published: November 2021

AbstractBackground & AimsReaching efficacious drug delivery to target cells/tissues represents a major obstacle in the current treatment of solid malignancies including hepatocellular carcinoma (HCC). In this study, we developed a pipeline to selective add complex‐sugars to the aglycone 4‐methylumbelliferone (4MU) to help their bioavailability and tumour cell intake.MethodsThe therapeutic efficacy of sugar‐modified rutinosyl‐4‐methylumbelliferone (4MUR) and 4MU were compared in vitro and in an orthotopic HCC model established in fibrotic livers. The mechanistic bases of its selective target to liver tumour cells were evaluated by the interaction with asialoglycoprotein receptor (ASGPR), the mRNA expression of hyaluronan synthases (HAS2 or HAS3) and hyaluronan deposition.Results4MUR showed a significant antiproliferative effect on liver tumoural cells as compared to non‐tumoural cells in a dose‐dependent manner. Further analysis showed that 4MUR is incorporated mostly into HCC cells by interaction with ASGPR, a receptor commonly overexpressed in HCC cells. 4MUR‐treatment decreased the levels of HAS2 and HAS3 and the cytoplasmic deposition of hyaluronan. Moreover, 4MUR reduced CFSC‐2G activation, hence reducing the fibrosis. In vivo efficacy showed that 4MUR treatment displayed a greater tumour growth inhibition and increased survival in comparison to 4MU. 4MUR administration was associated with a significant reduction of liver fibrosis without any signs of tissue damage. Further, 60% of 4MUR treated mice did not present macroscopically tumour mass post‐treatment.ConclusionOur results provide evidence that 4MUR may be used as an effective HCC therapy, without damaging non‐tumoural cells or other organs, most probably due to the specific targeting.
Larger, more connected societies of ants have a higher prevalence of viruses
Authors: Brahma Anindita , Leon Raphael Gray , Hernandez Gabriel Luis , Wurm Yannick 
Published: November 2021

AbstractThe benefits of cooperative living for foraging, nesting, defence and buffering environmental challenges lead animals with the most highly social lifestyles to dominate many ecosystems. However, living in larger, more highly connected groups should also increase the risks of pathogen exposure and transmission. While over long timescales selective responses could buffer the impacts of potential higher pathogen prevalence, similar processes are unlikely over short timescales. The red fire ant Solenopsis invicta is ideal for measuring the effects of group size on pathogen prevalence because two types of society coexist in this species: smaller single‐nest single‐queen colonies that are highly aggressive to their neighbours and larger multiple‐queen colonies that exchange resources with neighbouring nests. We compare the presence of viruses between these two colony types using metagenomic sequence classification of RNA‐sequencing reads. We find that queens from multiple‐queen colonies have 8.3‐times higher viral load and 1.5‐times higher viral diversity than queens from single‐queen colonies. This finding characterizes a rarely considered cost of transitions to more highly social living. Furthermore, our results show that highly social invertebrates can harbour many viruses.
Turkish Foreign Policy in a Neorealist Framework: Bilateral Relations Since 2016
Authors: Yilmaz Eren Alper 
Published: November 2021

AbstractIn the last five years, Turkish foreign policy in the regional and international arenas has followed a neorealist approach, mostly defensive, by establishing either cooperation or conflict with its allies, based on the dynamics of its domestic politics and the structure of the international system. Due especially to the coup attempt in 2016 and rising tension in Syria sparked by the activities of illegal groups, Turkey has usually followed a security‐oriented foreign policy to ensure national security and strengthen its strategic position within the framework of agreements in the military operations at its southern borders and its uncompromising principles regarding migration. The objective of this study is to analyze why Turkish foreign policy has followed a neorealist policy, by evaluating the bilateral relations with Turkey's core allies, the United States, Russia, and the European Union—ties that have survived at the highest level, even after the coup attempt and the Syrian conflict.
Philosophy doesn’t need a concept of progress
Authors: Shan Yafeng 
Published: November 2021

AbstractPhilosophical progress is one of the most controversial topics in metaphilosophy. It has been widely debated whether philosophy makes any progress in history. This paper revisits the concept of philosophical progress. It first identifies two criteria of an ideal concept of philosophical progress. It then argues that our accounts of philosophical progress fail to provide such an ideal concept. Finally, it argues that not only do we not have a good concept of philosophical progress, we also do not need a concept of philosophical progress in order to arrive at a good understanding of the history of philosophy.
Tasmanian Aboriginal Material Culture, Compensation, Belonging
Authors: Berk Christopher D. 
Published: November 2021

Abstract
The Tasmanian Aboriginal people have historically been defined by their visible lack of stereotypical “Aboriginal” characteristics and their supposed nonexistence. This article examines how Tasmanian Aboriginal individuals are bridging such gaps through material cultural production. In thinking about how communities mobilize the past to produce themselves in the present, I argue that canoes, kelp water carriers, and shell necklaces are vehicles through which alterity and distinction are rendered concrete. As such, these processes are best understood in relation to Bell and Geismar’s “materialization” and Ingold’s “meshworks.” Despite internal debates amongst practitioners over proper methodologies and styles, revitalized culture can be productively imagined as compensation for outward shortcomings and deficiencies. Efforts at revitalizing culture are willed connections to a deep ancestral past and represent the discursive enactment of a continuity that is often otherwise conspicuous by its absence. [material culture, cultural revitalization, Indigeneity, Tasmania, Australia]
“REFUGEE LOVE” IN A COLLEGE ART GALLERY: “Refugee Crafts” in the American Political Imaginary, 2017
Authors: Rodgers Susan 
Published: November 2021

abstractRefugees are often mischaracterized as either “threats” to their new nations of resettlement or as remarkably virtuous, resilient “survivors” of harsh expulsions from their home countries and difficult years in refugee camps. Both imageries fall short of forced migrants’ actual lives and stories. Museums’ display practices and their interpretations of “refugee arts” can easily fall into stereotypes, especially sugary, positive ones. This case study delves into display practices that led well‐intentioned curators and their student collaborators to lodge a small exhibition’s vision of refugees and their art production at superficial levels. Many universities now encourage students to conduct community‐based research and display findings in campus museums. This study argues that even well‐motivated shows on forced migrants’ art production should be executed with subtlety, so as to avoid inaccurate classification schemes regarding “refugee art.”
Thinking rhizomatically and becoming successful with disabled students in the accommodations assemblage: Using storytelling as method
Authors: Epstein Iris , Rose Jarrett R. , Juergensen Linda , Mykitiuk Roxanne , MacEntee Katie , Stephens Lindsay 
Published: November 2021

AbstractThe number of disabled students enrolled in higher education institutions is increasing. Yet in disciplines such as nursing, where placements are an important part of student success, students' lived experiences, though an important and necessary aspect of promoting equity, diversity, and inclusion, has been ignored. In this paper, we respond to such issues by creating and utilizing a novel storytelling method that harnesses the antiessentialist philosophy of Deleuze and Guattari. Storytelling empowers students to both describe their experiences and inform institutions on how to better serve them, and we use concepts from Deleuze and Guattari to provide a framework for thinking about students and their pathways toward success as multiple. As we show, applying storytelling as a method through this lens offers an expansion of strategies to put students first and, therefore, promote equity at the administrative, research, educational, and practical levels. We describe how thinking rhizomatically opens new avenues of insight, allowing for the creation of institutional assemblages based on a diverse array of students' needs, enabling them to become successful in their own ways.
Genomic and GWAS analyses demonstrate phylogenomic relationships of Gossypium barbadense in China and selection for fibre length, lint percentage and Fusarium wilt resistance
Authors: Zhao Nan , Wang Weiran , Grover Corrinne E. , Jiang Kaiyun , Pan Zhuanxia , Guo Baosheng , Zhu Jiahui , Su Ying , Wang Meng , Nie Hushuai , Xiao Li , Guo Anhui , Yang Jing , Cheng Cheng , Ning Xinmin , Li Bin , Xu Haijiang , Adjibolosoo Daniel , Aierxi Alifu , Li Pengbo , Geng Junyi , Wendel Jonathan F. , Kong Jie , Hua Jinping 
Published: November 2021

SummarySea Island cotton (Gossypium barbadense) is the source of the world’s finest fibre quality cotton, yet relatively little is understood about genetic variations among diverse germplasms, genes underlying important traits and the effects of pedigree selection. Here, we resequenced 336 G. barbadense accessions and identified 16 million SNPs. Phylogenetic and population structure analyses revealed two major gene pools and a third admixed subgroup derived from geographical dissemination and interbreeding. We conducted a genome‐wide association study (GWAS) of 15 traits including fibre quality, yield, disease resistance, maturity and plant architecture. The highest number of associated loci was for fibre quality, followed by disease resistance and yield. Using gene expression analyses and VIGS transgenic experiments, we confirmed the roles of five candidate genes regulating four key traits, that is disease resistance, fibre length, fibre strength and lint percentage. Geographical and temporal considerations demonstrated selection for the superior fibre quality (fibre length and fibre strength), and high lint percentage in improving G. barbadense in China. Pedigree selection breeding increased Fusarium wilt disease resistance and separately improved fibre quality and yield. Our work provides a foundation for understanding genomic variation and selective breeding of Sea Island cotton.