bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aortic root repair in a patient with acquired hemophilia A: case report
Authors: Gok Emre , Akay Mehmet H. , de Armas Ismael Salas , Klein Kimberly , Tint Hlaing , Allison Paul M. , Chen Alice J. , Akkanti Bindu , Kar Biswajit , Gregoric Igor D. 
Published: August 2021

Abstract
Background
Patients with acquired hemophilia A (AHA) who require open heart surgery have a life-threatening risk of hemorrhage. Limited data exist to guide perioperative management of these patients.

Case presentation
A 53-year-old female with rheumatoid arthritis, concomitant aortic valve endocarditis, and severe aortic regurgitation presented to our hospital. Bleeding and abnormal coagulation tests were noted during the initial workup, and she was diagnosed with AHA. The perioperative management plan included the use of pharmaceuticals, porcine recombinant factor VIII, and blood products. Extensive preoperative coagulation data were obtained, and factor VIII levels were continuously monitored to mitigate bleeding complications. The aortic valve replacement and root repair were uneventful.

Conclusion
Cardiac surgery in patients with AHA is possible as long as complex perioperative hemostatic and hematology management is used.
Successful limb salvage beyond the golden time following blunt traumatic open complete transection of the femoral artery and vein in a patient with cardiac arrest: a case report
Authors: Himura Hoshi , Uchida Kenichiro , Miyashita Masahiro , Mizobata Yasumitsu 
Published: August 2021

Abstract
Background
Open complete transection of the femoral artery and vein following blunt trauma is extremely rare. Furthermore, even if the patient has been successfully resuscitated, it is sometimes difficult in most patients to preserve the injured limb, especially after damage control resuscitation. We report a case of open complete transection of the femoral artery and vein secondary to high-energy blunt trauma and a successful limb preservation treatment strategy.

Case presentation
A 57-year-old Asian man was transferred to hospital after having fallen from the 15th floor of a condominium. The patient was in cardiac arrest at the scene, but was successfully resuscitated by emergency medical services staff. On arrival, the patient’s hemodynamics were completely collapsed with active external bleeding from the thigh, so we immediately started resuscitation including activation of massive transfusion protocol and temporarily ligated the transected proximal superficial femoral artery, deep femoral artery just distal after branching lateral femoral circumflex artery and the superficial femoral vein. Following radiological findings showing a potential pelvic fracture with active bleeding, we also performed retroperitoneal packing in the resuscitation room and moved the patient to the angiography room for transcatheter arterial embolization. The patient’s consciousness was preserved and perfusion of the injured limb was barely maintained after his hemodynamics were adequately stabilized. As we detected weak perfusion of the lower limb via a potential collateral flow from the lateral femoral circumflex artery branches from deep femoral artery by pulse doppler of the dorsal pedis artery, we decided to reconstruct superficial femoral artery and vein at 24 h after injury using great saphenous vein bypass grafts. The patient was transferred to a rehabilitation hospital with good neurological and limb outcome after hospitalization for 52 days.

Conclusion
We successfully preserved the patient’s lower limb after cardiac arrest and complete transection of the femoral artery and vein and achieved a good neurological outcome. Even if a femoral artery needs to be ligated temporarily, careful observation and assessment should be performed so as not to lose the chance to salvage the limb even during damage control resuscitation.
Inheritance and reflection: “re-study” of three anthropology fieldwork sites in China’s Yunnan Province
Authors: Wang Mingming 
Published: August 2021

AbstractThis article is a research report involving three anthropological studies conducted during the period of “Kuige” and their “re-studies.” By narrating the project, I set forth my views on the connections and differences between Chinese anthropological explorations from two historical periods. These anthropological explorations refer to the study of Lu Village conducted by Fei Xiaotong, that of “West Town” (Xizhou) by Francis L. K. Hsu, and that of “Pai-IPai” (Dai) villages by Tien Ju-Kang. They were all completed in the late 1930s and early 1940s. Each writer extracted a framework to analyze the land system, ancestor worship, and the relationship between humans and gods from the writer’s own field experience. Despite the difference in research methods, all three studies noticed the cultural differences between rural society and modernity. Since 2000, Peking University and Yunnan Minzu University have launched a “Province-university Cooperation Project.” During the project, a research team formed of several young scholars revisited Lu Village, “West Town” (Xizhou), and Namu Village. These writers’ works were based on the data acquired in their fieldwork and drew upon the opinions raised by global anthropologists on “re-study” in recent decades. Considering the dual effects of social change and shifts in academic concepts around “follow-up research,” the scholars put forward several points of view with their ethnographies, which all featured the characteristics of inheritance and reflection. Based on the results of the three “re-studies,” this article emphasizes the importance of the study of public rituals for the research of rural society. This article also attempts to re-examine the methodology of “human ecology,” which profoundly impacts Chinese anthropology and sociology.
Tracking the dissemination of Erwinia amylovora in the Eurasian continent using a PCR targeted on the duplication of a single CRISPR spacer
Authors: Kurz Mirjam , Carnal Simon , Dafny-Yelin Mery , Mairesse Orly , Gottsberger Richard A. , Ivanović Milan , Grahovac Mila , Lagonenko Alexander L. , Drenova Nataliya , Zharmukhamedova Galiya , Doolotkeldieva Tinatin , Smits Theo H. M. , Rezzonico Fabio 
Published: August 2021

AbstractFire blight is the most devastating disease affecting pome fruit production globally. The pathogen is native to North America and was imported to western Europe in the 1950s, progressively spreading over the continent in the ensuing decades. Previous phylogenetic studies have revealed the extreme genetic homogeneity of the pathogen outside its center of origin, which makes epidemiological studies difficult. These are generally only possible using hypervariable regions of the genome such as those represented by CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats), which are, however, not practical to sequence due to their size and variability. Here, we present a simple PCR assay targeting the duplication of a single CRISPR spacer in Erwinia amylovora that was found to be an important marker to discriminate between two main European populations of the pathogen. We implemented the assay on a total of 582 isolates to follow the spread of fire blight across the continent over several decades and, wherever possible, within single countries. The results obtained point to the occurrence of two major separate introduction events for E. amylovora in Europe that occurred approximately 20 years apart, and confirmed the existence of two principal distribution areas located in Northeastern Europe and the Eastern Mediterranean Basin from which the pathogen moved on to colonize the Eurasian continent.
Comparison of intrinsic exercise capacity and response to acute exercise in ICR (Institute of Cancer Research) mice derived from three different lineages
Authors: Hwang Dong-Joo , Kwon Ki-Chun , Choi Dong-Hun , Song Hyun-Keun , Kim Kil-Soo , Jung Young-Suk , Hwang Dae-Youn , Cho Joon-Yong 
Published: August 2021

AbstractBackgroundAs a laboratory animal resource, the ICR mouse is commonly used in a variety of research fields. However, information on differences in exercise-related characteristics in ICR mice derived from different lineages and the underlying mechanisms remains to be elucidated. In this study, we investigated the intrinsic exercise capacity and a magnitude of response to acute exercise, and sought to identify mechanisms contributing to difference in Korl:ICR (a novel ICR lineage recently established by the National Institute of Food and Drug Safety Evaluation, Korea) and two commercialized ICR lineages derived from different origins (viz., A:ICR mouse from Orient Bio Com, the United States, and B:ICR mouse from Japan SLC Inc., Japan).ResultsResults showed that despite no significant difference in body weight and weight-proportioned tissue mass of heart and skeletal muscles among groups, the relatively low intrinsic exercise capacity and exaggerated response to acute exercise were identified in B:ICR comparted with Korl:ICR and A:ICR, as reflected by total work and lactate threshold (LT). Also, the mitochondrial efficiency expressed as the complex 1 and complex 1 + 2 respiratory control ratio (RCR) values for cardiac mitochondrial O2consumption in B:ICR was significantly lower than that in Korl:ICR with higher level of state 2 respiration by glutamate/malate and UCP3 expression in cardiac muscle.ConclusionsTaken together, these results indicate that the intrinsic exercise capacity of ICR mouse varies according to lineages, suggesting the role of cardiac mitochondrial coupling efficiency as a possible mechanism that might contribute to differences in the intrinsic exercise capacity and magnitude of response to exercise.
Correlation between CT chest severity score (CT-SS) and ABO blood group system in Egyptian patients with COVID-19
Authors: Mansour Mohamed G. , Abdelrahman Ahmed S. , Abdeldayem Emad H. 
Published: August 2021

Abstract
Background
The 2019 coronavirus disease (COVID-19) has become a global health crisis. CT chest is considered as an important investigation for early diagnosis as well as assessment of severity of COVID-19 pneumonia. Several articles reported that there is a correlation between ABO blood group system and susceptibility as well as prognosis of the disease. In our study we correlated the CT severity score (CT-SS) and the ABO blood group in patients with COVID-19 infection. This study involved 547 symptomatic patients with pathologically proven COVID-19 infection (positive PCR); non contrast CT chest was done for all cases and CT severity score (CT-SS) was calculated followed by its correlation with the patients’ ABO blood group. Aim of the work was to evaluate the relation between CT-SS and the ABO blood groups in Egyptian patients with COVID-19 infection.

Results
The mean CT-SS in patients with blood group A patients (n = 153; 28%) was 13.7 (moderate severity), while in patients with blood group O (n = 227; 41.5%) the mean CT-SS was 6.7 (mild severity). In blood group B patients (n = 139; 25.4%) the mean CT-SS was 9.1 (mild to moderate severity) and in blood group AB patients (n = 28; 5.1%) the mean CT-SS was 9.7 (mild to moderate severity).

Conclusion
COVID-19 patients with blood group A are more prone to aggressive CT findings (higher CT-SS) and consequently may be susceptible to increased risk of mortality compared to the patients with other blood groups; however, patients with blood group O are suggested to have the least CT-SS and appear to be relatively protected.
Gravimetry and petrophysics for defining the intracratonic and rift basins of the Western-Central Africa zone
Authors: Maddaloni Francesca , Pivetta Tommaso , Braitenberg Carla 
Published: August 2021

The global gravity field obtained from the observations of the satellite Gravity Field and Steady-State Ocean Circulation Explorer (GOCE) satellite offers new opportunities in defining density variations of earth’s crust and mantle, allowing new insights into the structure of specific geologic features. The Central African Rift is a key feature in understanding the dismemberment of Gondwana, and we contribute to defining the crustal density structure underlying the rift. The presence of a narrow and up to 12 km deep basin implies crustal stretching allowed the sediment to accumulate, but a key question is whether the stretching processes also affected the deeper layers of the crust or was limited to the upper crust. The study area includes a subbasin of the greater Chad sag basin, which extends over 1500 × 1500 km and occupies the center of North-Central Africa, shared between the countries of Chad, Sudan, Nigeria, Niger, Algeria, Libya, and Cameroon. We find that the rifting affected the lower crust of the West African Rift, and we evaluate evidence for a 1500 km long and several km thick magmatic crustal intrusion presumably associated with underplating and crustal thinning. We estimate that the stretching factor must be at least 1.5 and had affected the entire crust. To our knowledge, the identification of a continuous body of magmatic intrusions is new and has been only possible through the recent global gravity field. The magmatism has altered the thermal conditions from the time of emplacement on, and it is relevant for the maturation of hydrocarbons present in the sediments. The timing of the magmatism is presumably tied to two pulses of volcanism documented in the rift, associated with the first postrift phase from 96 to 88 Ma and the second postrift phase from 23 Ma up to the Quaternary.
Sonographic features of various dental materials and foreign bodies
Authors: Çağlayan Fatma , Yozgat İlbaş Fatma Nur 
Published: August 2021

Objective: To reveal the sonographic characteristics of various foreign bodies and dental materials to aid diagnosis. Methods and materials: 24 objects consisting of various dental materials and foreign bodies were included in the study. Objects were embedded in bovine gelatin. Images of the objects were obtained by conventional radiography and ultrasonography (USG). Opacities were evaluated by conventional radiography. Their visibility and posterior acoustic behaviors were examined by USG. In addition, the actual sizes of the objects and their dimensions measured by USG were compared. Results: All objects included in the study, including non-opaque ones, could be visualized by USG. When the posterior acoustic behavior of objects was examined, 15 of the objects (62.5%) caused posterior acoustic shadowing on USG. While 6 of the objects (25%) did not have any USG artifacts, 2 of them (8,3%) had comet tail artifact and 1 of them (4,2%) had reverberation artifact. There was no statistically significant difference between the actual dimensions of the objects and their dimensions measured by USG (p > 0,05). Conclusion: USG is a very useful technique for imaging foreign bodies and dental materials, it can even show objects that cannot be seen in X-rays on in-vitro environment.
Automatic segmentation of the temporomandibular joint disc on magnetic resonance images using a deep learning technique
Authors: Nozawa Michihito , Ito Hirokazu , Ariji Yoshiko , Fukuda Motoki , Igarashi Chinami , Nishiyama Masako , Ogi Nobumi , Katsumata Akitoshi , Kobayashi Kaoru , Ariji Eiichiro 
Published: August 2021

Objectives: The aims of the present study were to construct a deep learning model for automatic segmentation of the temporomandibular joint (TMJ) disc on magnetic resonance (MR) images, and to evaluate the performances using the internal and external test data. Methods: In total, 1200 MR images of closed and open mouth positions in patients with temporomandibular disorder (TMD) were collected from two hospitals (Hospitals A and B). The training and validation data comprised 1000 images from Hospital A, which were used to create a segmentation model. The performance was evaluated using 200 images from Hospital A (internal validity test) and 200 images from Hospital B (external validity test). Results: Although the analysis of performance determined with data from Hospital B showed low recall (sensitivity), compared with the performance determined with data from Hospital A, both performances were above 80%. Precision (positive predictive value) was lower when test data from Hospital A were used for the position of anterior disc displacement. According to the intra-articular TMD classification, the proportions of accurately assigned TMJs were higher when using images from Hospital A than when using images from Hospital B. Conclusion: The segmentation deep learning model created in this study may be useful for identifying disc positions on MR images.
Strategies for cellular deconvolution in human brain RNA sequencing data
Authors: Sosina Olukayode A. , Tran Matthew N. , Maynard Kristen R. , Tao Ran , Taub Margaret A. , Martinowich Keri , Semick Stephen A. , Quach Bryan C. , Weinberger Daniel R. , Hyde Thomas , Hancock Dana B. , Kleinman Joel E. , Leek Jeffrey T. , Jaffe Andrew E. 
Published: August 2021

Background: Statistical deconvolution strategies have emerged over the past decade to estimate the proportion of various cell populations in homogenate tissue sources like brain using gene expression data. However, no study has been undertaken to assess the extent to which expression-based and DNAm-based cell type composition estimates agree. Results: Using estimated neuronal fractions from DNAm data, from the same brain region (i.e., matched) as our bulk RNA-Seq dataset, as proxies for the true unobserved cell-type fractions (i.e., as the gold standard), we assessed the accuracy (RMSE) and concordance (R2) of four reference-based deconvolution algorithms: Houseman, CIBERSORT, non-negative least squares (NNLS)/MIND, and MuSiC. We did this for two cell-type populations - neurons and non-neurons/glia - using matched single nuclei RNA-Seq and mismatched single cell RNA-Seq reference datasets. With the mismatched single cell RNA-Seq reference dataset, Houseman, MuSiC, and NNLS produced concordant (high correlation; Houseman R2 = 0.51, 95% CI [0.39, 0.65]; MuSiC R2 = 0.56, 95% CI [0.43, 0.69]; NNLS R2 = 0.54, 95% CI [0.32, 0.68]) but biased (high RMSE, >0.35) neuronal fraction estimates. CIBERSORT produced more discordant (moderate correlation; R2 = 0.25, 95% CI [0.15, 0.38]) neuronal fraction estimates, but with less bias (low RSME, 0.09). Using the matched single nuclei RNA-Seq reference dataset did not eliminate bias (MuSiC RMSE = 0.17). Conclusions: Our results together suggest that many existing RNA deconvolution algorithms estimate the RNA composition of homogenate tissue, e.g. the amount of RNA attributable to each cell type, and not the cellular composition, which relates to the underlying fraction of cells.
Educational interventions for shared decision making and the role of patient agency: A Systematic Review
Authors: Witkop Catherine , Torre Dario , Harvey Emily , Maggio Lauren 
Published: August 2021

Background: Shared decision making is critical to patient-centered care and yet there is limited consensus on effective teaching approaches for training physicians in this domain. As a collaborative process in which the patient and physician co-create a decision, patient and relational agency may be important contributors and studies with patient-reported outcomes may identify successful approaches and determine gaps in pedagogy. The authors conducted a systematic review of educational interventions for shared decision making, focusing on patient-reported outcomes and consideration of agency. Methods: Ovid MEDLINE, Embase, and Web of Science were searched for studies describing educational interventions with patient-level outcomes published between January 2000 and January 2020. Articles were excluded if they were not in English, included only patient interventions, or reported only physician outcomes. Quality assessment was performed using the Medical Education Research Study Quality Instrument (MERSQI). Data about the educational methods used were extracted and included studies were assessed for quality. Thematic analysis was performed to identify the potential role of agency. Results: 26 articles were identified describing 17 unique studies. Educational interventions were diverse in duration and content, with multiple components. Three-quarters of studies used role play or simulated patients and 82% included tools to facilitate shared decisions. Although no articles explicitly discussed facilitating agency as a component of the intervention or as an outcome, one qualitative study demonstrated themes of patient and relational agency. Conclusions: Educational interventions included small group discussion, decision aids, role play, and simulated patients, and improved a range of patient outcomes, but our study included only studies including practicing physicians, limiting applicability to trainees and other health care providers. Interventions have not included explicit instructional design around agency, but qualitative analyses demonstrated interventions may facilitate agency and shared decision making. Future instructional strategies should consider the complexity inherent in co-constructing decisions.
Trust, Incomplete Contracting, and Corporate Innovation
Authors: Xie Fei , Zhang Bohui , Zhang Wenrui 
Published: August 2021

Innovation is a contract-intensive economic activity in a world of incomplete contracts. We show that trust mitigates incomplete contracting and enhances innovation by acting as an informal contracting mechanism. Trust plays an especially important role when formal laws and regulations are lacking, and it promotes innovation by encouraging collaboration and fostering tolerance for failure. Further analyses show that trust also facilitates cross-border technological spillover and innovation collaboration. Overall, our evidence highlights innovation as a key conduit through which trust affects economic growth. This paper was accepted by Gustavo Manso, finance.