bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemanfaatan Google Meet, Google Classroom, dan Zoom Untuk Mendukung Kegiatan Belajar dari Rumah
Authors: Arifiyanti Amalia Anjani , F Muhammad Burhanuddin , M Sudewantoro N , A Ananda Lakunti , Rozi M. Rizal Abdullah 
Published: September 2021

Abstract: The school from home program implemented by all educational institutions during the COVID 19 pandemic forced all parties to adapt. This school from home program requires information technology as the medium so that the teaching and learning process continues. One of the challenges that arise from this distance learning method is the ability to operate information technology, especially applications used to support the online learning process. One of the activities to answer this challenge is to conduct training that directly practices how to operate an online learning support application. This training program attended by parents and students in the Sukodono District, Sidoarjo Regency. This training is carried out online due to a social restriction policy at the time of the training. The evaluation results and feedback from the training participants stated an increase in understanding of the operation of the applications being taught; besides, the participants indicated that the community needed similar training. However, the participants hope that the next training will be carried out offline to teach the participants step-by-step directly. Keywords: Google Meet; Google Classroom; school from home; training; Zoom Abstrak: Program belajar dari rumah yang dilaksanakan semua instansi pendidikan selama masa pandemi COVID 19, memaksa semua pihak yang terlibat untuk beradaptasi. Program belajar dari rumah ini membutuhkan teknologi informasi sebagai medianya agar proses belajar mengajar tetap berjalan. Salah satu tantangan yang muncul dari metode belajar jarak jauh ini adalah kemampuan pengoperasian teknologi informasi terutama aplikasi-aplikasi yang digunakan untuk mendukung proses belajar daring. Salah satu kegiatan untuk menjawab tantangan ini adalah dengan mengadakan pelatihan yang langsung mempraktekkan cara peng-operasian pengoperasian aplikasi pendukung belajar daring. Pelatihan ini diikuti oleh para orang tua dan siswa di wilayah Kecamatan Sukodono, Kabupaten Sidoarjo. Pelatihan ini dilaksanakan secara daring karena adanya kebijakan pem-batasan sosial pada saat pelatihan berlangsung. Hasil evaluasi dan timbal balik dari peserta pelatihan menyatakan bahwa terjadi peningkatan pemahaman terhadap pengoperasian aplikasi yang diajarkan, selain itu peserta menyatakna bahwa pelatihan sejenis dibutuhkan oleh masyarakat. Akan tetapi peserta berharap agar pelatihan selanjutnya dilaksanakan secara luring sehingga instruktur dapat mengajari peserta tahap demi tahap secara langsung.Kata kunci: belajar dari rumah; google meet; Google Classroom; pelatihan; Zoom
Pola Konsumsi Makanan Satwika Pada Bhakta Hare Krishna di Sri Sri Krishna Balarama Ashram Denpasar
Authors: Sutana I Gede 
Published: September 2021

Makanan merupakan sarana untuk bertahan hidup. Dalam hal makanan, manusia memiliki kebudayaan masing-masing mengenai pola konsumsi makanan. Pada penelitian ini, yang menarik adalah Bhakta Hare Krishna di Sri Sri Krishna Balarama Ashram Denpasar memiliki pola konsumsi makanan tersendiri yang berbeda dengan masyarakat pada umumnya. Bhakta Hare Krishna di Sri Sri Krishna Balarama Ashram Denpasar tidak mengkonsumsi makanan yang mengandung daging, ikan, dan telur. Pola konsumsi makanan ini disebut dengan pola konsumsi makanan satwika. Adapun pengamatan dalam tulisan ini adalah terkait dengan pola konsumsi makanan satwika pada Bhakta Hare Krishna di Sri Sri Krishna Balarama Ashram Denpasar. Dalam pengamatan lebih lanjut teori pilihan rasional dan fungsionalisme struktural menjadi pisau analisis untuk mengungkap pola konsumsi makanan satwika pada Bhakta Hare Krishna di Sri Sri Krishna Balarama Ashram Denpasar.
Secara hasil pengamatan ini diperoleh hal-hal yang mendorong Bhakta Hare Krishna menerapakan pola konsumsi makanan satwika didasari oleh aturan yang berlaku, pilihan rasional bhakta, dan fungsional terhadap kehidupan baik kehidupan jasmani maupun spiritual. Pola konsumsi makanan satwika menunjukkan lima komponen yang berlaku diantaranya (1) cara memperoleh bahan makanan satwika, (2) jenis-jenis bahan makanan satwika, (3) menu makanan satwika, (4) cara mengolah makanan satwika, dan (5) cara menghidangkan makanan satwika. Serta implikasi yang diperoleh dari penerapan pola konsumsi makanan satwika berimplikasi terhadap fisik, mental dan spiritual.
Kata Kunci: Pola Konsumsi Makanan Satwika, Bhakta Hare Krishna, Sri Sri Krishna Balarama Ashram Denpasar
Keterkaitan Sisi Negatif Era Milenial Dengan Ramalan Keadaan Kali Yuga
Authors: Darma Permana I Dewa Gede 
Published: September 2021

Abstrak
Berbicara mengenai era Milenial saat ini, tak akan bisa lepas dari istilah generasi Milenial sebuah generasi yang berumur produktif dengan ciri khas lahir di dunia dengan perkembangan sains dan teknologi yang sudah semakin pesat. Dalam ajaran Agama Hindu sendiri, kurun waktu sekarang disebut sebagai Kali Yuga sebutan zaman kegelapan yang diperkirakan sudah dimulai sekitar 5000 tahun yang lalu. Di zaman Kali, keadaan dunia sudah tidak lagi menentu, penuh kekacauan, dan penerapan ajaran agama hanya mendapatkan porsi sekadarnya. Sehingga, umat manusia utamanya generasi muda pada zaman ini, mulai melupakan Tuhan karena dianggap tabu. Jika dilihat secara lebih mendalam, kurun waktu era Milenial berjalan beriringan dengan Kali Yuga yang terjadi pada waktu sekarang. Dari kaca mata tersebut, memandang era Milenial untuk memahaminya secara lebih mendalam dari perspetif Veda sebagai pedoman hidup Umat Hindu adalah pokok pembahasan dalam tulisan ini. Hal ini dilakukan dengan cara mencari literatur-literatur yang berkaitan dengan hal tersebut dengan tujuan menemukan keterkaitan antara perkembangan penggunaan teknologi di era Milenial dengan sifat gelap Kali Yuga.
Kata Kunci: Era Milenial, Veda, Kali Yuga
Pengaruh Belanja Daerah dan Tenaga Kerja terhadap Output Sektor Swasta di Sumatera Selatan
Authors: Ulum Muhammad Bahrul 
Published: September 2021

The purpose of this study was to determine the effect of regional spending namely direct and indirect spending, labor on the private sector in South Sumatra. The data used are secondary data in the form of time series 2006-2017 sourced from the DGT Ministry of Finance and the Central Statistics Agency (BPS) which have been processed. This research uses the Multiple Linear Regression analysis methods with Ordinary Least Square (OLS) method. The results of this study indicate that during 2006-2017 the expenditure variable directly had a positive and significant effect on private-sector output in South Sumatra. The indirect expenditure variable has a positive and significant effect on private-sector output in South Sumatra. Labor variables have a positive and significant effect on private-sector output in South Sumatra. Overall independent variables have a significant effect on the output of the private sector in South Sumatra.

Abstrak
Tujuan penelitian ini untuk mengetahui pengaruh belnja daerah yakni belanja langsung dan belanja tidak langsung, tenaga kerja terhadap sektor swasta di Sumatera Selatan. Data yang digunakan adalah data sekunder dalam bentuk time series tahun 2006-2017 yang bersumber dari DJPK Kementerian Keuangan dan Badan Pusat Statistik (BPS) yang telah diolah. Penelitian ini menggunakan metode analisis Regresi Linier Berganda dengan metode Ordinary Least Square (OLS). Hasil penelitian ini menunjukan hasil bahwa selama tahun 2006-2017 variabel belanja langsung berpengaruh positif dan signifikan terhadap output sektor swasta di Sumatera Selatan. Variabel belanja tidak langsung berpengaruh positif dan signifikan terhadap output sektor swasta di Sumatera Selatan. Variabel tenaga kerja berpengaruh positif dan signifikan terhadap output sektor swasta di Sumatera Selatan. Secara keseluruhan variabel bebas berpengaruh signifikan terhadap output sektor swasta di Sumatera Selatan.
Kata kunci: Belanja Langsung, Belanja Tidak Langsung, Tenaga Kerja, Output Sektor Swasta
Construction and Validation of a Novel Immunosignature for Overall Survival in Uveal Melanoma
Authors: Gu Chufeng , Gu Xin , Wang Yujie , Yao Zhixian , Zhou Chuandi 
Published: September 2021

ObjectivesUveal melanoma (UM) is the most common primary intraocular malignancy in adults, and immune infiltration plays a crucial role in the prognosis of UM. This study aimed to generate an immunological marker-based predictive signature for the overall survival (OS) of UM patients.MethodsSingle-sample gene-set enrichment analysis (ssGSEA) was used to profile immune cell infiltration in 79 patients with UM from The Cancer Genome Atlas (TCGA) database. Univariate and multivariate least absolute shrinkage and selection operator (LASSO) Cox regressions were used to determine the prognostic factors for UM and construct the predictive immunosignature. Receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and calibration curves were performed to evaluate the clinical ability and accuracy of the model. In addition, the predictive accuracy was compared between the immunosignature and the Tumor, Node, Metastasis (TNM) staging system of American Joint Committee on Cancer (AJCC). We further analyzed the differences in clinical characteristics, immune infiltrates, immune checkpoints, and therapy sensitivity between high- and low-risk groups characterized by the prognostic model.ResultsHigher levels of immune cell infiltration in UM were related to a lower survival rate. Matrix metallopeptidase 12 (MMP12), TCDD inducible poly (ADP-ribose) polymerase (TIPARP), and leucine rich repeat neuronal 3 (LRRN3) were identified as prognostic signatures, and an immunological marker-based prognostic signature was constructed with good clinical ability and accuracy. The immunosignature was developed with a concordance index (C-index) of 0.881, which is significantly better than that of the TNM staging system (p&lt; 0.001). We further identified 1,762 genes with upregulated expression and 798 genes with downregulated expression in the high-risk group, and the differences between the high- and low-risk groups were mainly in immune-related processes. In addition, the expression of most of the immune checkpoint-relevant and immune activity-relevant genes was significantly higher in the high-risk group, which was more sensitive to therapy.ConclusionWe developed a novel immunosignature constructed by MMP12, TIPARP, and LRRN3 that could effectively predict the OS of UM.
O-Glycosylation Landscapes of SARS-CoV-2 Spike Proteins
Authors: Zhang Yong , Zhao Wanjun , Mao Yonghong , Chen Yaohui , Zheng Shanshan , Cao Wei , Zhu Jingqiang , Hu Liqiang , Gong Meng , Cheng Jingqiu , Yang Hao 
Published: September 2021

The densely glycosylated spike (S) proteins that are highly exposed on the surface of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) facilitate viral attachment, entry, and membrane fusion. We have previously reported all the 22 N-glycosites and site-specific N-glycans in the S protein protomer. Herein, we report the O-glycosylation landscapes of SARS-CoV-2 S proteins, which were characterized through high-resolution mass spectrometry. Following digestion with trypsin and trypsin/Glu-C, and de-N-glycosylation using PNGase F, we determined the GalNAc-type O-glycosylation pattern of S proteins, including O-glycosites and the six most common O-glycans occupying them, via Byonic identification and manual validation. Finally, 255 intact O-glycopeptides composed of 50 peptides sequences and 43 O-glycosites were discovered by higher energy collision-induced dissociation (HCD), and three O-glycosites were confidently identified by electron transfer/higher energy collision-induced dissociation (EThcD) in the insect cell-expressed S protein. Most glycosites were modified by non-sialylated O-glycans such as HexNAc(1) and HexNAc(1)Hex (1). In contrast, in the human cell-expressed S protein S1 subunit, 407 intact O-glycopeptides composed of 34 peptides sequences and 30 O-glycosites were discovered by HCD, and 11 O-glycosites were unambiguously assigned by EThcD. However, the measurement of O-glycosylation occupancy hasn’t been made. Most glycosites were modified by sialylated O-glycans such as HexNAc(1)Hex (1)NeuAc (1) and HexNAc(1)Hex (1)NeuAc (2). Our results reveal that the SARS-CoV-2 S protein is an O-glycoprotein; the O-glycosites and O-glycan compositions vary with the host cell type. These comprehensive O-glycosylation landscapes of the S protein are expected to provide novel insights into the viral binding mechanism and present a strategy for the development of vaccines and targeted drugs.
Obesity: Epidemiology, Pathophysiology, and Therapeutics
Authors: Lin Xihua , Li Hong 
Published: September 2021

Obesity is a complex multifactorial disease that accumulated excess body fat leads to negative effects on health. Obesity continues to accelerate resulting in an unprecedented epidemic that shows no significant signs of slowing down any time soon. Raised body mass index (BMI) is a risk factor for noncommunicable diseases such as diabetes, cardiovascular diseases, and musculoskeletal disorders, resulting in dramatic decrease of life quality and expectancy. The main cause of obesity is long-term energy imbalance between consumed calories and expended calories. Here, we explore the biological mechanisms of obesity with the aim of providing actionable treatment strategies to achieve a healthy body weight from nature to nurture. This review summarizes the global trends in obesity with a special focus on the pathogenesis of obesity from genetic factors to epigenetic factors, from social environmental factors to microenvironment factors. Against this background, we discuss several possible intervention strategies to minimize BMI.
Cortical Venous Changes on Susceptibility-Weighted Imaging Predict the Cerebral Collateral Circulation as Confirmed by Digital Subtraction Angiography
Authors: Zhan Yun-Hao , Chen Yang-Kun , Li Run-Xiong , Luo Gen-Pei , Wu Zhi-Qiang , Liu Yong-Lin , Xiao Wei-Min , Hu Wei-Dong , Xie Cai-Qin 
Published: September 2021

Objective: Asymmetrical cortical vein sign (ACVS) shown on susceptibility-weighted imaging (SWI) can reflect regional hypoperfusion. We investigated if ACVS could predict the cerebral collateral circulation (CC) as assessed by digital subtraction angiography (DSA) in acute ischemic stroke patients with ipsilateral severe stenosis/occlusion of the anterior circulation.Methods: Clinical data and imaging data of 62 acute ischemic stroke patients with ipsilateral severe stenosis or occlusion of the anterior circulation confirmed by DSA were collected retrospectively. Participants underwent magnetic resonance imaging, including an SWI sequence. ACVS was defined as more and/or larger venous signals in the cerebral cortex of one side of SWI than that in the contralateral side. ACVS was measured using the Alberta Stroke Program Early Computed Tomography score based on SWI. The grading of the cerebral CC was judged using DSA.Results: Of the 62 patients, 30 patients (48.4%) had moderate-to-severe ACVS. According to DSA assessment, 19 patients (30.6%) had a good CC (grade 3–4), and 43 (69.4%) patients had a poor-to-moderate CC (grade 0–2). Among the 30 patients with moderate-to-severe ACVS, only three (10%) patients had a good CC, and 27 (90%) patients had a poor-to-moderate CC; among the 32 patients with none or mild ACVS, 16 (50%) of them had a good CC, and the other 50% had a moderate-to-severe CC. We constructed two logistic regression models with ACVS grading and none or mild ACVS entered into the models, respectively, together with age and large-artery occlusion. In model 1, no ACVS (compared with severe ACVS; OR = 40.329, 95%CI = 2.817–577.422, P = 0.006), mild ACVS (compared with severe ACVS; OR = 17.186, 1.735–170.224, 0.015) and large-artery occlusion (OR = 45.645, 4.603–452.592, 0.001) correlated with a good CC. In model 2, none or mild ACVS (OR = 36.848, 95%CI = 5.516–246.171, P &lt; 0.001) was significantly associated with a good CC as judged by DSA, adjusted by age and large-artery occlusion.Conclusions: Cortical venous changes in SWI may be a useful indicator for the cerebral CC as confirmed by DSA.
Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research
Authors: Llibre-Guerra Jorge J. , Behrens Maria Isabel , Hosogi Mirna Lie , Montero Lucia , Torralva Teresa , Custodio Nilton , Longoria-Ibarrola Erika Mariana , Giraldo-Chica Margarita , Aguillón David , Hardi Angela , Maestre Gladys E. , Contreras Valeria , Doldan Celeste , Duque-Peñailillo Lissette , Hesse Heike , Roman Norbel , Santana-Trinidad Dhara Angelina , Schenk Christian , Ocampo-Barba Ninoska , López-Contreras Ricardo , Nitrini Ricardo 
Published: September 2021

Introduction:The historical development, frequency, and impact of frontotemporal dementia (FTD) are less clear in Latin America than in high-income countries. Although there is a growing number of dementia studies in Latin America, little is known collectively about FTD prevalence studies by country, clinical heterogeneity, risk factors, and genetics in Latin American countries.Methods:A systematic review was completed, aimed at identifying the frequency, clinical heterogeneity, and genetics studies of FTD in Latin American populations. The search strategies used a combination of standardized terms for FTD and related disorders. In addition, at least one author per Latin American country summarized the available literature. Collaborative or regional studies were reviewed during consensus meetings.Results:The first FTD reports published in Latin America were mostly case reports. The last two decades marked a substantial increase in the number of FTD research in Latin American countries. Brazil (165), Argentina (84), Colombia (26), and Chile (23) are the countries with the larger numbers of FTD published studies. Most of the research has focused on clinical and neuropsychological features (n= 247), including the local adaptation of neuropsychological and behavioral assessment batteries. However, there are little to no large studies on prevalence (n= 4), biomarkers (n= 9), or neuropathology (n= 3) of FTD.Conclusions:Future FTD studies will be required in Latin America, albeit with a greater emphasis on clinical diagnosis, genetics, biomarkers, and neuropathological studies. Regional and country-level efforts should seek better estimations of the prevalence, incidence, and economic impact of FTD syndromes.
Efficacy and Tolerability of Perampanel as Adjunctive Therapy in Chinese Patients With Focal-Onset Seizures: An Observational, Prospective Study
Authors: Zhang Ranran , Qiao Shan , Fang Xiqin , Wang Kemo , Shi Yanting , Du Qianwen , Yang Tingting , Liu Xuewu 
Published: September 2021

Purpose: To evaluate the efficacy and tolerability of adjunctive perampanel (PER) in Chinese patients with focal-onset seizures, with or without secondarily generalized tonic-clonic seizures.Methods: Fifty-six patients aged 14–72 years were recruited consecutively in this single-center prospective observational study. All patients received PER as add-on treatment on the basis of clinical judgment. Seizure frequency, adverse events (AEs), and retention rates were obtained at 3 and 6 months after PER introduction.Results: The overall response rates were 60 and 71.1% after 3 and 6 months, respectively, and the freedom of seizures at the same points were reached in 8 and 15.8%. The retention rates were 89.3% at the 3-month follow-up and 67.9% at the 6-month follow-up. The overall incidence of adverse events was 55.4%. The leading reported AEs were dizziness (39.3%) and somnolence (25%).Conclusions: Our study confirmed the efficacy and tolerability of adjunctive PER in Chinese patients in real-life conditions. Based on our treatment experience, a lower maintenance dose of PER would be needed in Chinese patients.
Fluorescence Imaging Using Enzyme-Activatable Probes for Real-Time Identification of Pancreatic Cancer
Authors: Takahashi Ryugen , Ishizawa Takeaki , Sato Masumitsu , Inagaki Yoshinori , Takanka Mariko , Kuriki Yugo , Kamiya Mako , Ushiku Tetsuo , Urano Yasuteru , Hasegawa Kiyoshi 
Published: September 2021

IntroductionRadical resection is the only curative treatment for pancreatic cancer, which is a life-threatening disease. However, it is often not easy to accurately identify the extent of the tumor before and during surgery. Here we describe the development of a novel method to detect pancreatic tumors using a tumor-specific enzyme-activatable fluorescence probe.MethodsTumor and non-tumor lysate or small specimen collected from the resected specimen were selected to serve as the most appropriate fluorescence probe to distinguish cancer tissues from noncancerous tissues. The selected probe was sprayed onto the cut surface of the resected specimen of cancer tissue to acquire a fluorescence image. Next, we evaluated the ability of the probe to detect the tumor and calculated the tumor-to-background ratio (TBR) by comparing the fluorescence image with the pathological extent of the tumor. Finally, we searched for a tumor-specific enzyme that optimally activates the selected probe.ResultsUsing a library comprising 309 unique fluorescence probes, we selected GP-HMRG as the most appropriate activatable fluorescence probe. We obtained eight fluorescence images of resected specimens, among which four approximated the pathological findings of the tumor, which achieved the highest TBR. Finally, dipeptidyl-peptidase IV (DPP-IV) or a DPP-IV-like enzyme was identified as the target enzyme.ConclusionThis novel method may enable rapid and real-time visualization of pancreatic cancer through the enzymatic activities of cancer tissues.