bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and functional analysis of novel oncogene DDX60L in pancreatic ductal adenocarcinoma
Authors: Wu Hongjin , Tian Weiwei , Tai Xiang , Li Xuanpeng , Li Ziwei , Shui Jing , Yu Juehua , Wang Zhihua , Zhu Xiaosong 
Published: November 2021

Abstract
Background
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer. Approximately 80% of patients initially diagnosed with locally advanced or metastatic disease survive only 4–11 months after diagnosis. Tremendous efforts have been made toward understanding the biology of PDAC.

Results
In this study, we first utilized next-generation sequencing technique and existing microarray datasets to identify significant differentially expressed genes between PDAC and non-tumor adjacent tissue. By comparing top significant survival genes in PDAC Gene Expression Profiling Interactive Analysis database and PDAC transcriptome data from patients, our integrated analysis discovered five potential central genes (i.e., MYEOV, KCNN4, FAM83A, S100A16, and DDX60L). Subsequently, we analyzed the cellular functions of the potential novel oncogenes MYEOV and DDX60L, which are highly expressed in PDAC cells. Notably, the knockdown of MYEOV and DDX60L significantly inhibited the metastasis of cancer cells and induced apoptosis. Further RNA sequencing analyses showed that massive signaling pathways, particularly the TNF signaling pathway and nuclear factor-kappa B (NF-κB) signaling pathway, were affected in siRNA-treated cancer cells. The siDDX60L and siMYEOV significantly inhibited the expression of chemokine CXCL2, which may potentially affect the tumor microenvironment in PDAC tissues.

Conclusions
The present findings identified the novel oncogene DDX60L, which was highly expressed in PDAC. Transcriptome profiling through siRNA knockdown of DDX60L uncovered its functional roles in the PDAC in humans.
Extubation in the operating room results in fewer composite mechanical ventilation-related adverse outcomes in patients after liver transplantation: a retrospective cohort study
Authors: Xu Yan , Zuo Yiding , Zhou Li , Hao Xuechao , Xiao Xiao , Ye Mao , Bo Lulong , Jiang Chunling , Yang Jiayin 
Published: November 2021

AbstractBackgroundTo investigate the effect of extubation in the operating room (OR) on mechanical ventilation-related adverse outcomes in patients who undergo liver transplantation.MethodsPatients who underwent liver transplantation between January 2016 and December 2019 were included. According to the timing of extubation, patients were divided into OR extubation group and intensive care unit (ICU) extubation group. The propensity score was used to match OR extubation group and ICU extubation group at a 1:2 ratio by demographical and clinical covariates. The primary outcome was a composite of mechanical ventilation-related adverse outcomes, including 30-day all-cause mortality, in-hospital acute kidney injury (stage 2 or 3), and in-hospital moderate to severe pulmonary complications. Secondary outcomes included in-hospital moderate to severe infectious complications, unplanned reintubation rates, ICU and postoperative hospital lengths of stay, and total hospital cost.ResultsA total of 438 patients were enrolled. After propensity score matching, 94 patients were in OR extubation group and 148 patients were in ICU extubation group. Incidence of the composite mechanical ventilation-related adverse outcomes was significantly lower in OR extubation group than ICU extubation group, even after adjusting for confounding factors (19.1%vs.31.8%; Odds Ratio, 0.509; 95% Confidence Index [CI], 0.274-0.946;P=0.031). The duration of ICU stay was much shorter in OR extubation group than ICU extubation group (median 4, Interquartile range [IQR] (3 ~ 6)vs.median 6, IQR (4 ~ 8);P<0.001). Meanwhile, extubation in the OR led to a significant reduction of total hospital cost compared with extubation in the ICU (median 3.9, IQR (3.5 ~ 4.6) 10000 US dollarsvs.median 4.1, IQR (3.8 ~ 5.1) 10000 US dollars;P=0.021). However, there were no statistically significant differences in moderate to severe infectious complications, unplanned reintubation rates, and the length of postoperative hospital stay between groups.ConclusionsAmong patients who underwent liver transplantation, extubation in the OR compared with extubation in the ICU, significantly reduced the primary composite outcome of 30-day all-cause mortality, in-hospital acute kidney injury (stage 2 or 3), or in-hospital moderate to severe pulmonary complications.Trial registrationThe trial was registered atwww.clinicaltrials.govwith registration number NCT04261816. Retrospectively registered on 1st February 2020.
Low-touch, team-based care for co-morbidity management in cancer patients: the ONE TEAM randomized controlled trial
Authors: Zullig Leah L. , Shahsahebi Mohammad , Neely Benjamin , Hyslop Terry , Avecilla Renee A. V. , Griffin Brittany M. , Clayton-Stiglbauer Kacey , Coles Theresa , Owen Lynda , Reeve Bryce B. , Shah Kevin , Shelby Rebecca A. , Sutton Linda , Dinan Michaela A. , Zafar S. Yousuf , Shah Nishant P. , Dent Susan , Oeffinger Kevin C. 
Published: November 2021

Abstract
Background
As treatments for cancer have improved, more people are surviving cancer. However, compared to people without a history of cancer, cancer survivors are more likely to die of cardiovascular disease (CVD). Increased risk for CVD-related mortality among cancer survivors is partially due to lack of medication adherence and problems that exist in care coordination between cancer specialists, primary care physicians, and cardiologists.

Methods/Design
The Onco-primary care networking to support TEAM-based care (ONE TEAM) study is an 18-month cluster-randomized controlled trial with clustering at the primary care clinic level. ONE TEAM compares the provision of the iGuide intervention to patients and primary care providers versus an education-only control. For phase 1, at the patient level, the intervention includes video vignettes and a live webinar; provider-level interventions include electronic health records-based communication and case-based webinars. Participants will be enrolled from across North Carolina one of their first visits with a cancer specialist (e.g., surgeon, radiation or medical oncologist). We use a sequential multiple assignment randomized trial (SMART) design.
Outcomes (measured at the patient level) will include Healthcare Effectiveness Data and Information Set (HEDIS) quality measures of management of three CVD comorbidities using laboratory testing (glycated hemoglobin [A1c], lipid profile) and blood pressure measurements; (2) medication adherence assessed pharmacy refill data using Proportion of Days Covered (PDC); and (3) patient-provider communication (Patient-Centered Communication in Cancer Care, PCC-Ca-36).
Primary care clinics in the intervention arm will be considered non-responders if 90% or more of their participating patients do not meet the modified HEDIS quality metrics at the 6-month measurement, assessed once the first enrollee from each practice reaches the 12-month mark. Non-responders will be re-randomized to either continue to receive the iGuide 1 intervention, or to receive the iGuide 2 intervention, which includes tailored videos for participants and specialist consults with primary care providers.

Discussion
As the population of cancer survivors grows, ONE TEAM will contribute to closing the CVD outcomes gap among cancer survivors by optimizing and integrating cancer care and primary care teams. ONE TEAM is designed so that it will be possible for others to emulate and implement at scale.

Trial registration
This study (NCT04258813) was registered in clinicaltrals.gov on February 6, 2020.
Impact of chemotherapy and radiotherapy on the survival of elderly esophageal cancer patients undergoing surgery: a SEER database analysis
Authors: Li Xinrong , Zhang Jin , Ye Chenxiao , Zhu Junquan , Guo Kaibo , Guo Yong 
Published: November 2021

Abstract
Background
Esophageal cancer (EC) is a common and lethal carcinoma; however, the effectiveness and feasibility of the chemo- and radio-therapy (CRT) for the elderly patients (≥ 70 years) with surgery have not been fully discussed. The purpose of this study was to investigate the potential effect of CRT on the prognosis.

Methods
A total of 1085 patients (534 CRT patients vs. 551 non-CRT patients) from 1998 to 2016 were collected from the Surveillance, Epidemiology, and End Results database according to the inclusion and exclusion criteria. Using the competing risk regression and survival analysis, an overall estimation of the effectiveness of CRT was performed on a well-balanced cohort via performing propensity score matching. Then, the specific impact of CRT on high- (n = 557) and low-risk (n = 528) cohorts derived from the nomogram’s risk quantification for every patient were further evaluated respectively. Additionally, the advantages of the nomogram model and the conventional tumor, node, metastasis (TNM, 6th revision) staging system were compared.

Results
A better survival outcome was observed among patients receiving both surgery and CRT than those who underwent surgery alone (HR: 0.55, 95% CI 0.45–0.68, P < 0.001), especially for those with tumors characterized by poor differentiation, large tumor size, advanced T staging, lymphatic metastasis, and distant metastasis (HR: 0.48, 95% CI 0.39–0.59, P < 0.001), while no benefit was observed among the low-risk patients. Furthermore, the newly established nomogram model might be better than the TNM (6th revision) staging system but more data needed.

Conclusion
Aggressive treatments, such as surgery, chemotherapy, and radiotherapy, were considered effective for selected elderly patients with EC according to the newly established nomogram model.
Prediction of the degree of pathological differentiation in tongue squamous cell carcinoma based on radiomics analysis of magnetic resonance images
Authors: Yu Baoting , Huang Chencui , Xu Jingxu , Liu Shuo , Guan Yuyao , Li Tong , Zheng Xuewei , Ding Jun 
Published: November 2021

Abstract
Background
Tongue squamous cell carcinoma (TSCC) is one of the most difficult malignancies to control. It displays particular and aggressive behaviour even at an early stage. The purpose of this paper is to explore the value of radiomics based on magnetic resonance fat-suppressed T2-weighted images in predicting the degree of pathological differentiation of TSCC.

Methods
Retrospective analysis of 127 patients with TSCC who were randomly divided into a primary cohort and a test cohort, including well-differentiated, moderately differentiated and poorly differentiated. The tumour regions were manually labelled in fat-suppressed T2-weighted imaging (FS-T2WI), and PyRadiomics was used to extract radiomics features. The radiomics features were then selected by the least absolute shrinkage and selection operator (LASSO) method. The model was established by the logistic regression classifier using a 5-fold cross-validation method, applied to all data and evaluated using the area under the receiver operating characteristic curve (AUC), accuracy, sensitivity and specificity.

Results
In total, 1132 features were extracted, and seven features were selected for modelling. The AUC in the logistic regression model for well-differentiated TSCC was 0.90 with specificity and precision values of 0.92 and 0.78, respectively, and the sensitivity for poorly differentiated TSCC was 0.74.

Conclusions
The MRI-based radiomics signature could discriminate between well-differentiated, moderately differentiated and poorly differentiated TSCC and might be used as a biomarker for preoperative grading.
Out of pocket costs and time/productivity losses for pediatric sepsis in Uganda: a mixed-methods study
Authors: Krepiakevich A. , Khowaja A. R. , Kabajaasi O. , Nemetchek B. , Ansermino J. M. , Kissoon N. , Mugisha N. K. , Tayebwa M. , Kabakyenga J. , Wiens M. O. 
Published: November 2021

Abstract
Background
Sepsis disproportionately affects children from socioeconomically disadvantaged families in low-resource settings, where care seeking may consume scarce family resources and lead to financial hardships. Those financial hardships may, in turn, contribute to late presentation or failure to seek care and result in high mortality during hospitalization and during the post discharge period, a period of increasingly recognized vulnerability. The purpose of this study is to explore the out-of-pocket costs related to sepsis hospitalizations and post-discharge care among children admitted with sepsis in Uganda.

Methods
This mixed-methods study was comprised of focus group discussions (FGD) with caregivers of children admitted for sepsis, which then informed a quantitative cross-sectional household survey to measure out-of-pocket costs of sepsis care both during initial admission and during the post-discharge period. All participants were families of children enrolled in a concurrent sepsis study.

Results
Three FGD with mothers (n = 20) and one FGD with fathers (n = 7) were conducted. Three primary themes that emerged included (1) financial losses, (2) time and productivity losses and (3) coping with costs. A subsequently developed cross-sectional survey was completed for 153 households of children discharged following admission for sepsis. The survey revealed a high cost of care for families attending both private and public facilities, although out-of-pocket cost were higher at private facilities. Half of those surveyed reported loss of income during hospitalization and a third sold household assets, most often livestock, to cover costs. Total mean out-of-pocket costs of hospital care and post-discharge care were 124.50 USD and 44.60 USD respectively for those seeking initial care at private facilities and 62.10 USD and 14.60 USD at public facilities, a high sum in a country with widespread poverty.

Conclusions
This study reveals that families incur a substantial economic burden in accessing care for children with sepsis.
Fear of falling and physical activity in hemodialysis patients: a pilot study
Authors: Shirai Nobuyuki , Yamamoto Suguru , Osawa Yutaka , Tsubaki Atsuhiro , Morishita Shinichiro , Nitami Sumiyo , Narita Ichiei 
Published: November 2021

Abstract
Background
Hemodialysis (HD) patients are at a high risk of falls and fractures. The amount of physical activity (PA) they perform may be limited by psychosomatic factors associated with fear of falling, leading to frailty progression. This study aimed to clarify the relationship between fear of falling and PA in patients undergoing HD.

Methods
This cross-sectional study included 46 HD patients. Fear of falling was evaluated using the Modified Falls Efficacy Scale (MFES). A 3-axis accelerometer was used to measure PA, including number of steps; 1 to 1.9 METs = static PA, 2 to 2.9 = light PA, and 3 or more = moderate to vigorous PA (MVPA). We examined correlation of MFES with each type of PA. Factors affecting fear of falling were determined using multiple regression analysis.

Results
The median MFES was 9.2 (7.4, 10.0). MFES was associated with the number of steps (r = 0.608, p < 0.001), light PA (r = 0.421, p = 0.004), and MVPA (r = 0.546, p < 0.001). Eighteen participants (39.1%) experienced at least one fall in a year and had lower MFES than the non-fall group (fall group: 7.4 [5.1, 9.0] vs. non-fall group: 9.7 [8.5, 10.0], p < 0.001). Multiple regression analysis showed that MFES was independently associated with the number of steps (B = 279.7, 95% confidence interval [CI] = 90.5–469.0, p = 0.005) and MVPA (B = 3.52, 95% CI = 1.14–5.90, p = 0.005), respectively.

Conclusions
Fear of falling was associated with amount of PA among patients undergoing HD. Interventions that target the fear of falling may be effective in reducing HD patients’ fall risk by enhancing PA.
Electrodeposition of nano-Cu, Ni and binary Ni/Cu into nano-porous AAO layer for high-efficiency black spectrally selective coating
Authors: Hussein H. S. , Shaffei M. F. , Abouelata Ahmed M. Awad , Abdel-Fatah Mona A. 
Published: November 2021

Abstract
Background
Anodic aluminum oxide (AAO) template is widespread due to its diverse metal nanostructures. Various solar selective black coatings on aluminum oxide template were investigated. Spectrally selective nano-coating of nickel, copper and nickel–copper on anodized aluminum was produced.

Results
The coatings were performed via electrodeposition and evaluated by measurement of coating thickness, hardness and optical properties. Also, these coatings were analyzed by scanning electron microscope, energy-dispersive X-ray spectroscopic and polarization studies in 3.5% NaCl solution. The anodized aluminum showed higher corrosion resistance (4.8284 KΩ) and lower corrosion rate (0.02189 mm/year). However, the electro-colored Al with Cu for 60 min showed the highest corrosion rate of 0.1942 mm/y, compared with other Al samples. The effect of anodizing time on the metal density and the optical efficiency of black copper coating was studied.

Results
The obtained solar panels exhibit low values of solar reflectance within the visible range and high solar absorption efficiency. These coatings are highly efficient and adequate for any solar system.
Preparative Synthesis of 1,3-Dialkyltetrazolium-5-thiolates from 1-Alkyltetrazole-5-thiols
Authors: Hirashita Tsunehisa , Murakami Suguru , Shoji Takuo , Kurabayashi Hideaki , Araki Shuki 
Published: November 2021

Abstract
Mesoionic 1,3-dialkyltetrazolium-5-thiolates can be prepared in good yields by alkylation of 1-alkyltetrazole-5-thiols with secondary alcohols in concentrated sulfuric acid. The thiolates are transformed into the corresponding olates through S-alkylation followed by hydrolysis. The olates were found to be liquid at room temperature and to work effectively as polar solvents. The use of a smaller amount of sulfuric acid led to drastically different products; S-bridged dimers linked by 1,2-dimethylethylene were formed as the major products.
Supported Nickel Zeolite Catalyst for Oxidative Conversion of Methane: Effect of Heteroatoms in the Zeolite Framework on Its Physicochemical and Catalytic Properties
Authors: Yasuda Shuhei , Kunitake Yusuke , Osuga Ryota , Nakamura Kengo , Matsumoto Takeshi , Sago Keita , Kondo Junko N , Yabushita Mizuho , Muramatsu Atsushi , Yokoi Toshiyuki 
Published: November 2021

Abstract
Supported nickel CHA-type zeolites with different framework compositions including borosilicate, gallosilicate and aluminosilicate were synthesized. The effect of heteroatoms in the framework on the state of the Ni species introduced was investigated. The size and dispersibility of the Ni species differed greatly depending on the heteroatom in the zeolite framework, and the use of the aluminosilicate-type framework led to the formation of a highly dispersed and nano-sized Ni species. Thus, prepared Supported Ni CHA-type aluminosilicate exhibited the highest catalytic performance in oxidative conversion of CH4.
An MRI-based radiomics signature and clinical characteristics for survival prediction in early-stage cervical cancer
Authors: Zheng Ru-ru , Cai Meng-ting , Lan Li , Huang Xiao Wan , Yang Yun Jun , Powell Martin , Lin Feng 
Published: November 2021

Objectives:
To investigate the prognostic role of magnetic resonance imaging (MRI)-based radiomics signature and clinical characteristics for overall survival (OS) and disease-free survival (DFS) in the early-stage cervical cancer.

Methods:
A total of 207 cervical cancer patients (training cohort: n = 144; validation cohort: n = 63) were enrolled. 792 radiomics features were extracted from T2W and diffusion-weighted imaging (DWI). 19 clinicopathological parameters were collected from the electronic medical record system. Least absolute shrinkage and selection operator (LASSO) regression analysis was used to select significant features to construct prognostic model for OS and DFS. Kaplan-Meier (KM) analysis and log-rank test were applied to identify the association between the radiomics score (Rad-score) and survival time. Nomogram discrimination and calibration were evaluated as well. Associations between radiomics features and clinical parameters were investigated by heatmaps.

Results:
A radiomics signature derived from joint T2W and DWI images showed better prognostic performance than that from either T2W or DWI image alone. Higher Rad-score was associated with worse OS (p &lt; 0.05) and DFS (p &lt; 0.05) in the training and validation set. The joint models outperformed both radiomics model and clinicopathological model alone for 3-year OS and DFS estimation. The calibration curves reached an agreement. Heatmap analysis demonstrated significant associations between radiomics features and clinical characteristics.

Conclusions:
The MRI-based radiomics nomogram showed a good performance on survival prediction for the OS and DFS in the early-stage cervical cancer. The prediction of the prognostic models could be improved by combining with clinical characteristics, suggesting its potential for clinical application.

Advances in knowledge:
This is the first study to build the radiomics-derived models based on T2W and DWI images for the prediction of survival outcomes on the early-stage cervical cancer patients, and further construct a combined risk scoring system incorporating the clinical features.
Clinical application of retrograde sural neurofasciocutaneous flap repair combined with jingulian capsules to treat foot and ankle soft tissue defects
Authors: Hao Zhiwei , Tian Shan , Hu Changqing , Jia Yan 
Published: November 2021

Objectives: To observe and analyse the efficacy of retrograde sural neurofasciocutaneous flap repair combined with Jingulian capsules to treat foot and ankle soft tissue defects.
Methods: One hundred and eighty patients with foot and ankle soft tissue defects were enrolled in the study from January 2016 to June 2019 in The Second Department of General Surgery, Baoding First Central Hospital. They were divided into a study group and a reference group with the same case number. The former group was provided combination treatment, i.e. retrograde sural neurofasciocutaneous flap repair combined with Jingulian capsules; the latter group was given vacuum sealing drainage. Then, the treatment outcomes of the two groups were compared.
Results: The study group needed fewer dressing changes, less preoperative preparation time and antibiotic use than the reference group, p<0.05. The study group had a significantly lower incidence of wound infections and flap necrosis than the reference group, p<0.05. The study group was significantly superior to the reference group regarding ankle function scores and the pain visual analogue scores (VAS) p<0.05.
Conclusions: Retrograde sural neurofasciocutaneous flap repair combined with Jingulian capsules is a protocol that improves efficacy for soft tissue defects in the foot and ankle, which are worthy of promotion and practice.
doi: https://doi.org/10.12669/pjms.38.1.4546
How to cite this:Hao Z, Tian S, Hu C, Jia Y. Clinical application of retrograde sural neurofasciocutaneous flap repair combined with jingulian capsules to treat foot and ankle soft tissue defects. Pak J Med Sci. 2022;38(1):190-194. doi: https://doi.org/10.12669/pjms.38.1.4546
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Weak module amenability for the second dual of a Banach algebra
Authors: Soltanmoradi Shabani , Ebrahimi Bagha Davood , Rahpeyma Pourbahri 
Published: November 2021

In this paper we study the weak module amenability of Banach algebras which are Banach modules over another Banach algebra with compatible actions. We show that for every module derivation D : A ↦ ( A/J_A )∗ if D∗∗(A∗∗) ⊆ WAP (A/J_A ), then weak module amenability of A∗∗ implies that of A. Also we prove that under certain conditions for the module derivation D, if A∗∗ is weak module amenable then A is also weak module amenable.