bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Evolution of Olecranon Fractures and Its Fixation Strategies
Authors: Tan Bryan , Ng Jingwen , Ng Wei Xiang , Yuan Wei , Kwek Ernest Beng Kee 
Published: November 2021

Abstract
Introduction.

Olecranon fractures are a common fracture of the upper extremity. The primary aim was to investigate the evolution of olecranon fractures and fixation method over a period of 12 years. The secondary aim was to compare complication rates of Tension Band Wiring (TBW) and Plate Fixation (PF).
Materials and Methods

Retrospective Study for all patients with surgically treated olecranon fractures from 1 January 2005 to 31 December 2016 from a tertiary trauma center. Records review for demographic, injury characteristics, radiographic classification and configuration, implant choices and complications. Results grouped into three 4-year intervals, analyzed comparatively to establish significant trends over 12 years.
Results

262 patients were identified. Demographically, increasing mean age (48.7 to 58.9 years old, p-value 0.004) and higher ASA scores (7.1% ASA 3 to 21.0% ASA 3 p-value 0.001). Later fractures were more oblique (fracture angle 86.1 to 100.0 degrees, p-value 0.001) and comminuted (Schatzker D type 10.4–30.0%, p-value 0.025, single fracture line 94.0–66.0%, p-value 0.001). Implant choice, sharp increase in PF compared to TBW (PF 16.0% to PF 80.2%, p-value 0.001). Complication-wise, TBW had higher rates of symptomatic implant, implant and bony failures and implant removal.
Conclusion

Demographic and fracture characteristic trends suggest that olecranon fractures are exhibiting fragility fracture characteristics (older age, higher ASA scores, more unstable, oblique and comminuted olecranon fractures). Having a high index of suspicion would alert surgeons to consider use of advanced imaging, utilize appropriate fixation techniques and manage the underlying osteoporosis for secondary fracture prevention. Despite this, trends suggest a potential overutilization of PF particularly for stable fracture patterns and the necessary precaution should be exercised.
Bruceine D and Afatinib Combination Inhibits Ovarian Cancer Cells Proliferation and Migration Through DNA Damage Repair and EGFR Pathway
Authors: Lin Feng , Zhu Ju-fan , Wang Luo , Yang Yuan-jun , Zheng Ru-ru , Zhang Xu , Hu Yan 
Published: November 2021

Abstract
Owing to the high rates of relapse and migration, ovarian cancer has been recognized as the most lethal gynecological malignancy worldwide. The activity of the EGFR signaling pathway is frequently associated with ovarian cancer cell proliferation and migration. Despite this knowledge, inhibition of EGFR signaling in ovarian cancer patients failed to achieve satisfactory therapeutic effects. In this study, we identified that Bruceine D and EGFR inhibitor, afatinib, combination resulted in synergistic anti- ovarian cancer effects. The results indicated that compared with one of both drugs alone, the combination of Bruceine D and afatinib slowed the DNA replication rate, inhibition of cell viability, and proliferation and clone formation. This resulted in cell cycle arrest and cell apoptosis. In addition, the combination of Bruceine D and afatinib possessed a stronger ability to inhibit the ovarian cancer cell adhesion and migration than treatment with Bruceine D or afatinib alone. Mechanistically, the combined treatment triggered intense DNA damage, suppressed DNA damage repair, and enhanced the inhibition of the EGFR pathway. These results demonstrated that compared with each pathway inhibition, combined blocking of both DNA damage repair and the EGFR pathway appears to more effective against ovarian cancer treatment. The results support the potential of Bruceine D and afatinib combination as a therapeutic strategy for ovarian cancer patients.
Acceptability of Supervised Injection Facilities Among Persons Who Inject Drugs in Upstate New York
Authors: Duncan Eliana , Shufelt Sarah , Barranco Meredith , Udo Tomoko 
Published: November 2021

Abstract
Background

Supervised injection facilities (SIFs) provide spaces where persons who inject drugs (PWID) can inject under medical supervision and access harm reductions services. Though SIFs are not formally established in the US, such facilities are being considered for approval in several New York State (NYS) communities. No data exists from PWID in NYS, and little from outside major US urban centers, on willingness to use SIFs and associated factors.
Methods

This analysis included 285 PWID (mean age=38.7; 57.7% male; 72.3% non-Hispanic white) recruited for a study on hepatitis C prevalence among PWID in Upstate New York, where participants were recruited from syringe exchange programs (n=80) and able to refer other PWID from their injection networks (n=223). Participants completed an electronic questionnaire that included a brief description of SIFs and assessed willingness to use SIFs. We compared sociodemographic characteristics, drug use/harm reduction history, healthcare experience, and stigma between participants who were willing vs. unwilling to use such programs.
Results

Overall, 67.4% were willing to use SIFs, 18.3% unwilling, and 14.4% unsure. Among those reporting being willing or unwilling, we found higher willingness among those who were currently homeless (91.8% vs. 74.6%; p=0.004), who had interacted with police in the past 12 months (85.7% vs. 74.5%; p=0.04), and who were refused service within a healthcare setting (100% vs. 77.1%; p=0.03).
Conclusion

Our results support SIF acceptability in several Upstate New York PWID communities, particularly among those reporting feelings of marginalization. A large proportion reported being unsure about usage of SIFs, suggesting room for educating PWID on the potential benefits of this service. Our results support SIF acceptability in NYS and may facilitate reaching PWID subgroups that are most marginalized, should SIFs become available.
The Comparison of a C-Shaped Partial Stapled Hemorrhoidopexy (C-PSH) Versus Circular Stapled Hemorrhoidopexy (CSH) in Patients with IV Grade Hemorrhoid: A Retrospective Study
Authors: He Jun , Zhou Meng-Dan , Wu Wen-Jing , Liu Zhi-Yong , Wang Dong , Yang Guan-Gen , Yang Qin-Yan , Shen Zhong 
Published: November 2021

Abstract
Aims
The aims of this study were to present a C-shaped partial stapled hemorrhoidopexy (C-PSH) in the treatment of IV grade hemorrhoid and to assess the clinical outcomes of this technique compared with circular stapled hemorrhoidopexy (CSH).
Methods
Conventional CSH kit matched with an intestinal spatula was used for performing C-PSH. One hundred and fifty eight patients who suffered IV grade hemorrhoid and underwent C-PSH or CSH at Hangzhou Third hospital between December 2017 and July 2019 were retrospected. Intraoperative and postoperative outcomes in both groups were collected and analyzed.
Results
Operative time, estimated blood loss and hospital stay were similar in both two groups (p values were 0.238, 0.563 and 0.101 respectively). Pain scores on the first defecation, 1st, 2nd, 3rd and 7th postoperative days in the C-PSH group were respectively lower than those in the CSH group, and the numeric rating scale (NRS) scores were 3.29±1.52 vs. 4.23±1.99 (p=0.001), 3.82±1.49 vs. 4.63±1.17 (p<0.001), 3.12±1.51 vs. 3.71±1.85 (p=0.030), 2.67±1.52 vs. 3.37±1.54 (p=0.005) and 1.34±0.92 vs.1.84±1.14 (p=0.003). Fecal urgency incidences in the C-PSH group were lower than those in the CSH group on the 1st, 2nd, 3rd and 7th postoperative days, and the incidences occurred in the C-PSH group vs. CSH group were 44.7% vs. 61.0% (p=0.041), 30.3% vs. 46.3% (p=0.038), 25.0% vs. 43.9% (p=0.013) and 13.2% vs. 35.4% (p=0.001) respectively. Overall postoperative complications rate occurred in the CSH group was higher than that in the C-PSH group, (16/82 vs. 6/76, p=0.035). Six patients suffered from anal stenosis in the CSH group and no patient suffered from stenosis in the C-PSH group (p=0.047). One year recurrence rate in the C-PSH group and CSH group was 8.0% (6/75) vs. 6.3% (5/79), (p=0.687).
Conclusions
The C-PSH seems to be an efficacy and safety technique in treating IV grade hemorrhoid. It has advantages in alleviating postoperative pain, fecal urgency and anal stenosis compared with CSH. It could be an alternative technique in the treatment of IV grade hemorrhoid.
Association of Socioeconomic Status Measures With Physical Activity and Subsequent Frailty in Older Adults
Authors: Kheifets Mark , Goshen Abigail , Goldbourt Uri , Witberg Guy , Eisen Alon , Kornowski Ran , Gerber Yariv 
Published: November 2021

Abstract
Background: Despite increased recognition, frailty remains a significant public health challenge. Methods: Using a population-based cohort of older adults, this study examined the relationship between socioeconomic status (SES) factors, physical activity and frailty. The study included 1,799 participants (mean [SD], age 75[6]; 53% women) from the "National Health and Nutrition Survey of Older Adults Aged 65 and Over in Israel", conducted in 2005-2006. A follow-up interview was performed 12-14 years later in a subgroup of 601 subjects (mean [SD], age 84[4]; 56% women). Extensive data including self-reported leisure-time physical activity (LTPA) and SES measures were assessed at baseline. Frailty was measured at follow-up. Results: All SES measures were strongly and positively associated with LTPA (all p<0.001). Eighty-two participants (14%) were classified as frail at follow-up. After age and sex adjustment and accounting for attrition bias using inverse probability weighting, baseline LTPA (OR=2.77, 95% CI: 1.57-4.90, for inactivity; OR=1.41, 95% CI: 0.75-2.68, for insufficient activity, compared with sufficient activity, Ptrend<0.001) was inversely associated with incident frailty. The association persisted after further adjustment for SES and comorbidity. Conclusion: Among older individuals, multiple SES measures were positively associated with LTPA, which was a strong predictor of lower subsequent frailty risk.
Improving food security for Labrador Inuit in Nunatsiavut, Labrador: A matter of health equity
Authors: Bowers Renee , Turner Gail , Graham Ian D. , Furgal Chris , Dubois Lise 
Published: November 2021

Abstract
Background

The current low state of food security amongst Inuit in Canada is influenced by policy choices. Policy actors develop and implement policies, yet few research studies include their perspectives. This study includes policy actors’ perspectives on gaps and areas of improvement for policies that pertain to food security for Labrador Inuit in Nunatsiavut. Nunatsiavut is one of the four Inuit land claim areas in northern Canada making up the Inuit homeland, or Inuit Nunangat. It is situated in northern Labrador in the province of Newfoundland and Labrador, Canada.

Methods

This qualitative study consisted of key informant interviews conducted from July 2020-December 2020 with policy actors that spanned the Nunatsiavut Government (regional Inuit government), Government of Newfoundland and Labrador (provincial government), the Government of Canada (federal government), non-governmental organizations and private industry. Participants were asked about their role, policy gaps and opportunities for improving policies that pertain to food security in Nunatsiavut. It also included initial insights from emergency food security measures implemented during the first wave of COVID-19 in 2020.

Results

Fifteen key informant interviews were completed, and three participants provided written responses. The results were reported as per the consolidated criteria for reporting qualitative studies (COREQ): 32–item checklist. Seven participants (39%) stated they developed policy, six participants (33%) stated they both developed and implemented policy and five participants (28%) stated they implemented policy. Seven themes were identified from discussions with policy actors. Policy recommendations to improve food security include improving transportation, social policies, and policy coherence in policy implementation. Five separate themes were identified from discussions on implementing emergency food security measures during the first wave of COVID-19 in Nunatsiavut. These included inadequacy of social policies, hidden poverty among people living in Nunatsiavut and future considerations for post- COVID-19 food security policies.

Conclusion

The results of this study show that improving food security in Nunatsiavut is a matter of health equity. During COVID-19, these inequities were further highlighted, demonstrating the importance of urgent action. Findings from this study can inform actions to improve existing and future policies that pertain to food security for Labrador Inuit in Nunatsiavut.
Preparation of Magadiite-Sodium Alginate Drug Carrier Composite by Pickering-Emulsion-Templated-Encapsulation Method and its Properties of Sustained Release Mechanism by Baker-Lonsdale and Korsmeyer-Peppas Model
Authors: Ge Mingliang , Li Xinxiang , Li Yueying , S.M. Jahangir Alam , Gui Yuee , Huang Yongchao , Cao Luoxiang , Liang Guodong , Hu Guoqing 
Published: November 2021

Abstract
In this study, the nanohybrid drug carrier were synthesized by Pickering emulsion-templated encapsulation (PETE) method to control the sustained-released properties of the nanohybrid drug carrier; magadiite-cetyltriphenyl phosphonium bromide (MAG-CTPB-KH550) and sodium alginate (NaC 6 H 7 O 6 ) was dissolved in the aqueous phase but metronidazole (C 6 H 9 N 3 O 3 ) was dissolved in the ethyl acetate (CH 3 COOC 2 H 5 ) of the oil phase; both the oil phase and the aqueous phase were mixed and dispersed to prepared organically-modified magadiite-sodium alginate (MAG–CTPB–KH550/SA) nanohybrid drug carrier. X-ray diffraction (XRD), Flourier transform infrared spectrometry (FTIR) and scanning electron microscopy (SEM) results were shown that the most of Sodium alginate (SA) were encapsulated into the MAG–CTPB–KH550 but a few of SA were intercalated into the inner space layers of MAG–CTPB–KH550, metronidazole was combined with carrier materials through physical apparent adsorption, ion exchange and electrostatic interaction. In vitro result, it was showed that the slow release was shown less than 10% content of Sodium alginate; whereas, it was reduced the initial release rate of Metronidazole but it was extended the sustained-released time. To reach at equilibrium, the sustained-released effects of the drug carrier were prepared with 10% of Sodium Alginate for 32 h and the maximum cumulative release percentage was 93.42 for 24 h. First order model, Baker-Lonsdale model and Korsmeyer-Peppas model were fitted to study the slow-release mechanism; the correlation coefficients (R 2 ) of the three models were found over 0.9; thus, it was well described the release kinetics behavior of drug carrier composites. The slow-release mechanisms of the drug carrier were performed swelling and dissolving but the barrier effects of the lamina that were reduced the dissolution rate of metronidazole.
Helicobacter pylori infection and related factors among pregnant women at Debre Tabor General Hospital, Northwest Ethiopia, 2021
Authors: Yisak Hiwot , debaka  , yeserk  
Published: November 2021

Abstract
Introduction: Infection with Helicobacter pylori is one of the most frequent chronic bacterial illnesses in humans, infecting more than half of the world's population. Pregnant mothers are the populations most vulnerable to Helicobacter pylori infection. The frequency of H. pylori infection during pregnancy varies greatly depending on where you live. The objective of his study was to assess the prevalence of Helicobacter pylori infection and associated factors among pregnant mothers following antenatal care at antenatal care clinic in Debre Tabor General Hospital, Debre Tabor, Ethiopia, 2021. Methods and materials: Institutional based cross-sectional study design was conducted. Bivariate and multivariate logistic regression analyses were carried out to assess potential factors with Helicobacter pylori infection. Variables associated with the prevalence of Helicobacter pylori infection with (p-value < 0.05) were considered as significant factors. Results: The prevalence of Helicobacter Pylori infection was 52(17.9%), with 95% (CI: 13.4 – 22.3%). Sixty-five point four percent (65.4%) of Helicobacter Pylori infection positive mothers had gastrointestinal problems and developed symptoms like abdominal cramp and diarrhea 01 (1.92%), loss of appetite10 (19.23%), hiccups 9(17.31%), abdominal pain i.e. worsen when the stomach is empty 19(36.54%), indigestion and frequent heart burn13 (25%) during the present pregnancy. Lesser frequency of hand washing practice AOR= 3.09, 95%CI (1.14-8.34). Use of soap for hand washing AOR=0.44, 95% CI (0.19 - 0.98), feeding unwashed vegetables and fruits AOR=2.279, 95%CI (1.03-5.04), not being anemic AOR =0.268, 95% CI (0.10- 0.71), were significantly associated with Helico bacter pylori infection. Conclusions: This study shows that the prevalence of H. pylori infection was not low. The levels of anemia which was strongly associated with the prevalence of H. pylori infection. This implies that Helicobacter Pylori infection is a public health problem.
Rationale and design of reGional network for Acute Myocardial Infarction (GAMI): protocol for a Prospective Cluster-randomized Intervention study of STEMI management
Authors: He Yibo , Liu Jin , Liu Liwei , Song Feier , Ying Ming , Sun Guoli , Ling Yihang , Liang Yan , Ye Jianfeng , Hu Yunzhao , Song Mingcai , Xu Qingbo , Chen Cong , Chen Guoqin , Tan Ning , Chen Jiyan , Liu Yong , Chen Shiqun 
Published: November 2021

Abstract
BackgroundTimely revascularization is essential for ST-segment elevation myocardial infarction (STEMI) patients to reduced mortality rate. However, it's seldom achieved due to patient and medical system-level barriers in China, especially in the rural area. It's needed to establish a regionally coordinated network to promote the early revascularization rate for STEMI patients.MethodsRegional network for Acute Myocardial Infarction (GAMI) is a multi-center, prospective, intervention study with regional intervention. It was carried out in 8 centers by 1:1 cluster randomization in south China with diverse economic and medical levels since 2016. The regional intervention were carried out in the intervention centers, which consisted of intensive public education and regional network construction for STEMI treatment, including community and online propaganda to raised patients' awareness of the treatment for STEMI and establishment of regional clinic-EMS-PCI transfer network for timely primary revascularization. Consecutive acute STEMI patients were enrolled for assessment of regional intervention according to the key performance indicators. The primary study endpoint was reperfusion rate, and secondary endpoints included change of pre-hospital delay, changes of in-hospital delay time and in-hospital outcomes. All patients were followed up for more than 1 year.DiscussionThe GAMI study is a prospective cluster-randomized intervention study, which would provide helpful evaluation of the effectiveness of enhanced public education and regional network construction on regional STEMI treatmentTrial registration: Clinical Trials, NCT03928119. Registered , 25 April, 2019， https://clinicaltrials.gov/ct2/show/NCT03928119?id=NCT03928119&draw=2&rank=1
“I Tried to Get Help About My Addiction but He Just Gave Me Tablets:” Male Aboriginal Drug and Alcohol Rehabilitation Clients’ Experiences and Preferences Speaking About Substance Use in Primary Care
Authors: Farnbach Sara , Fernando Jamie , Coyte Joe , Simms Matthew , Hackett Maree 
Published: November 2021

Abstract
Background Primary healthcare (PHC) services are crucial in supporting people with substance use problems. The aims of this study were to explore Aboriginal and Torres Strait Islander (hereafter Aboriginal) males in treatment for substance use problems experiences about speaking about their substance use with PHC staff, and their preferences for accessing PHC about their substance use.MethodsSemi-structured interviews with residential drug and alcohol rehabilitation treatment service clients. Thematic analysis was used to develop themes inductively and deductively. Two interviews were independently double coded by an Aboriginal researcher and the project was supported by an Aboriginal Advisory Group.ResultsTwenty male adults who self-identified as Aboriginal participated (mean age 27 years). Half reported visiting PHC and talking about their substance use before their residential service stay. Two major themes developed: (1) asking for help for substance use or mental health problems linked with substance use, (2) ways to improve access to PHC about substance use. Although some males were offered treatment, some were not, and others had concerns about the treatments offered. ConclusionThis research highlights opportunities to improve access and to better support Aboriginal males with substance use problems in PHC. Focus on culturally appropriate PHC and providing staff with training around substance use and treatment options may improve access. It is important to foster culturally appropriate services, develop PHC staff knowledge around substance use, focus on therapeutic relationships and have a range of treatment options available that can be tailored to individual circumstances.
Circuit Analysis and Optimization of GAA Nanowire FET Towards Low Power and High Switching
Authors: Sreenivas V. Bharath , Narendar Vadthiya 
Published: November 2021

Abstract
The main aim of this work is to study the effect of symmetric and asymmetric spacer length variations towards source and drain on n-channel SOI JL vertically stacked (VS) nanowire (NW) FET at 10 nm gate length (LG). Spacer length is proved to be one of the stringent metrics in deciding device performance along with width, height and aspect ratio (AR). The physical variants in this work are symmetric spacer length (LSD), source side spacer length (LS) and drain side spacer length (LD). The simulation results give highest ION/IOFF ratio with LD variation compared to LS and LSD, whereas latter two variations have similar effect on ION/IOFF ratio. At 25 nm (2.5 × LG) of LD, the device gives appreciable ON current with the highest ION/IOFF ratio (2.19 × 108) with optimum subthreshold slope (SS) and ensures low power and high switching drivability. Moreover, it is noticed that among optimal values of LS and LD, the device ION/IOFF ratio has an improvement of 22.69% as compared to other variations. Moreover, the effect of various spacer dielectrics on optimized device is also investigated. Finally, the CMOS inverter circuit analysis is performed on the optimized symmetric and asymmetric spacer lengths.
Fusion of Multi-Modality Biomedical Images Using Deep Neural Networks
Authors: Gupta Manish , Kumar Naresh , Gupta Neha , Zaguia Atef 
Published: November 2021

Abstract
With the recent advancement in the medical diagnostic tools, multi-modality medical images are extensively utilized as a lifesaving tool. An efficient fusion of medical images can improve the performance of various medical diagnostic tools. But, gathering of all modalities for a given patient is defined as an ill-posed problem as medical images suffer from poor visibility and frequent patient dropout. Therefore, in this paper, a novel image fusion model is designed to fuse multi-modality medical images. The proposed model model suffers from hyper-parameters tuning issue, therefore, a multi-objective differential evolution (MDE) is used to optimize the initial parameters of the proposed model. The fusion factor and edge strength metrics are utilized to form a multi-objective fitness function. The performance of the proposed model is validated by comparing the proposed model models with nine competitive models over fifteen benchmark images. Performance analysis reveal that the proposed model outperforms the competitive fusion models.