bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maintenance Therapy Can Improve the Oncologic Prognosis and Obstetrical Outcome of Patients With Atypical Endometrial Hyperplasia and Endometrial Cancer After Fertility-Preserving Treatment: A Multicenter Retrospective Study
Authors: He Yijiao , Wang Jianliu , Wang Yiqin , Zhou Rong , Lu Qun , Liu Guoli , Tang Huiru , Guo Hongyan , He Mian , Wu Guizhu 
Published: December 2021

ObjectiveTo evaluate the effect of maintenance therapy for patients with atypical endometrial hyperplasia (AEH) and early endometrial cancer (EC) after successful fertility-preserving management on prognosis and pregnancy outcome.MethodsWe performed a retrospectively analysis of 109 young women with atypical endometrial hyperplasia and early endometrioid endometrial cancer who had received complete response after fertility-preserving treatment at 5centers between May 2005 and March 2021. Maintenance therapy regimes included low-dose oral progesterone, levonorgestrel intrauterine device(LNG-IUD) and combination oral contraceptive (COC). The patients were divided into two groups, maintenance therapy group and non-maintenance therapy group. Clinical characteristics, treatment regimens, prognosis, and pregnancy outcome were compared between the two groups.ResultsThe overall disease recurrence rate of the maintenance therapy group was significantly lower than that of the non-maintenance therapy group (P &lt; 0.001). The recurrence rate of atypical endometrial hyperplasia and endometrial cancer in the maintenance therapy group were significantly lower than those in the non-maintenance group (P &lt; 0.001). Maintenance therapy can reduce pregnancy rates and live birth rates. Maintenance therapy can protect the endometrium in patients treated with assisted reproductive technology (ART), greatly reducing the recurrence rate after ART (P&lt;0.001).ConclusionMaintenance therapy plays a very important protective role in fertility-preserving treatment for patients with atypical endometrial hyperplasia and endometrial cancer, which could significantly reduce the risk of recurrence. It is recommended that patients could receive maintenance therapy as long as possible during the period from achieving complete response to pregnancy preparation if possible. It may provide recurrence-free survival long enough for childless young women to prepare for pregnancy in the future. It can also protect the endometrium of those who are preparing to use assisted reproductive technology, possibly by reducing the risk of recurrence by excessive stimulation with assisted reproductive drugs.
18KHT01, a Potent Anti-Obesity Polyherbal Formulation
Authors: Pandeya Prakash Raj , Lamichhane Ramakanta , Lamichhane Gopal , Lee Kyung-Hee , Lee Hyeong Kyu , Rhee Su-jin , Jung Hyun-Ju 
Published: December 2021

Obesity is a life-threatening metabolic disorder necessitating urgent development of safe and effective therapy. Currently, limited such therapeutic measures are available for obesity. The present study was designed to develop a novel, safe and effective herbal therapy for the management of obesity. A polyherbal formulation (18KHT01) was developed by homogeneously mixing a specific proportion of crude Quercus acutissima (acorn jelly powder), Camellia sinensis (dry leaf buds), and Geranium thunbergii (dry aerial part) along with Citrus limon (fruit juice). Synergistic antioxidant, antiadipogenic, and anti-obesity activities were evaluated by in vitro as well as in vivo studies. In vitro experiments revealed strong synergistic antioxidant and anti-adipogenic activities of 18KHT01. Molecular assessment of 18KHT01 showed significant down-regulation of vital adipogenic factors such as PPARγ, C/EBPα, aP2, SREBP-1c, FAS, and LPL. Based on the results of the preliminary toxicity study, 75 and 150 mg/kg, twice daily doses of 18KHT01 were administered to evaluate anti-obesity activity in diet-induced obese (DIO) C57BL/6J mice model. The major obesity-related parameters such as body weight, weight gain, food efficiency ratio, as well as serum lipid profile were significantly reduced by 18KHT01 with potential synergism. Also, the high-fat diet-induced insulin resistance was suggestively alleviated by the formulation, and thus ameliorated fasting blood glucose. Histological evaluation of liver and white adipose tissue revealed that the significant reduction of fat depositions and thus reduction of these tissue weights. Synergy evaluation experiments exhibited that the 18KHT01 offered strong synergism by improving efficacy and reducing the toxicity of its ingredients. Overall results evidenced the 18KHT01 as a safe and potent anti-obesity herbal therapy.
Novel Computerized Method for Automated Determination of Ventilatory Threshold and Respiratory Compensation Point
Authors: Kim Kyoung Jae , Rivas Eric , Prejean Brian , Frisco Dillon , Young Millennia , Downs Meghan 
Published: December 2021

Introduction: The ventilatory threshold (named as VT1) and the respiratory compensation point (named as VT2) describe prominent changes of metabolic demand and exercise intensity domains during an incremental exercise test.Methods: A novel computerized method based on the optimization method was developed for automatically determining VT1 and VT2 from expired air during a progressive maximal exercise test. A total of 109 peak cycle tests were performed by members of the US astronaut corps (74 males and 35 females). We compared the automatically determined VT1 and VT2 values against the visual subjective and independent analyses of three trained evaluators. We also characterized VT1 and VT2 and the respective absolute and relative work rates and distinguished differences between sexes.Results: The automated compared to the visual subjective values were analyzed for differences with t test, for agreement with Bland–Altman plots, and for equivalence with a two one-sided test approach. The results showed that the automated and visual subjective methods were statistically equivalent, and the proposed approach reliably determined VT1 and VT2 values. Females had lower absolute O2 uptake, work rate, and ventilation, and relative O2 uptake at VT1 and VT2 compared to men (p ≤ 0.04). VT1 and VT2 occurred at a greater relative percentage of their peak VO2 for females (67 and 88%) compared to males (55 and 74%; main effect for sex: p &lt; 0.001). Overall, VT1 occurred at 58% of peak VO2, and VT2 occurred at 79% of peak VO2 (p &lt; 0.0001).Conclusion: Improvements in determining of VT1 and VT2 by automated analysis are time efficient, valid, and comparable to subjective visual analysis and may provide valuable information in research and clinical practice as well as identifying exercise intensity domains of crewmembers in space.
Study on Pain Catastrophizing From 2010 to 2020: A Bibliometric Analysis via CiteSpace
Authors: Luo Huifang , Cai Zongliao , Huang Yanyi , Song Jiating , Ma Qing , Yang Xiangwei , Song Yang 
Published: December 2021

Purpose: This study aimed to evaluate the global scientific output of research on pain catastrophizing and explore the hotspots and frontiers from 2010 to 2020 using bibliometric methods.Methods: Publications regarding pain catastrophizing published from 2010 to 2020 were extracted from the Web of Science Core Collection. CiteSpace was used to analyze the number of publications, countries, institutions, journals, authors, cited references, and keywords using standard bibliometric indicators.Results: A total of 1,576 publications on pain catastrophizing were retrieved from 2010 to December 31, 2020. The number and rate of the annual publications gradually increased totally. Pain (130) was the most productive journal. Meanwhile, Pain ranked first in the frequency (1,432) and centrality (0.31) of the cited journals. The most productive country and institution in this frequency field were the United States (642) and the University of Washington (73), respectively. Jensen MP (34) was the most prolific author, and Sullivan MJL (1,196) ranked first among the cited authors. In the ranking of frequency in the cited references, the first article was a critical review about pain catastrophizing published by Quartana (100). The keyword “Low back pain” had the highest frequency (556). “Total hip” was identified as a frontier research item for 2016–2020.Conclusion: The findings of this bibliometric study provide the current status and trends in the clinical research of pain catastrophizing and may help researchers to identify hot topics and explore new research directions in this field.
The Psychological Impact of COVID-19 on Healthcare Workers in Saudi Arabia: A Year Later Into the Pandemic
Authors: Almalki Atiah H. , Alzahrani Mohammad S. , Alshehri Fahad S. , Alharbi Adnan , Alkhudaydi Samirah F. , Alshahrani Rawan S. , Alzaidi Aseel H. , Algarni Majed A. , Alsaab Hashem O. , Alatawi Yasser , Althobaiti Yusuf S. , Bamaga Ahmed K. , Alhifany Abdullah A. 
Published: December 2021

Objective: The COVID-19 pandemic poses unprecedented challenges to healthcare workers worldwide. This study sought to estimate the prevalence of depression, anxiety, and stress among healthcare workers in Saudi Arabia, and to identify the factors associated with these psychological disorders.Methods: A cross-sectional questionnaire-based study was conducted from January 21 to March 2, 2021. Physicians, pharmacists, nurses, and other healthcare workers from different parts of Saudi Arabia were recruited through snowball sampling. Psychological outcomes were measured using the Depression, Anxiety, and Stress Scale (DASS-21). Pearson's chi-square test was used to explore the bivariate association between diverse characteristics and each outcome. Multiple logistic regression analyses were performed to identify factors associated with depression, anxiety, and stress.Results: A total of 501 healthcare workers completed the survey, of whom 60% were female and nearly half were pharmacists. The majority (76.25%) of respondents reported that a family member, friend, or colleague had contracted COVID-19, and more than one-third (36%) knew someone who died due to COVID-19. Overall, the estimated prevalence rates of depression, anxiety, and stress were 54.69, 60.88, and 41.92%, respectively. The multivariate analysis revealed that healthcare workers with chronic diseases, nurses, and healthcare workers from the southern region were more likely to suffer from depression and stress. Further, individuals with positive COVID-19 test results showed a greater proportion of depressive symptoms compared to others. In addition, knowing someone who died due to COVID-19 and having a chronic illness were predisposing factors for anxiety.Conclusion: After more than a year, the prevalence of depression, anxiety, and stress remains substantial among healthcare workers in Saudi Arabia. The findings can help guide efforts to mitigate the psychological impact of the pandemic.
Capturing a Comprehensive Picture of Biological Events From Adverse Outcome Pathways in the Drug Exposome
Authors: Wu Qier , Bagdad Youcef , Taboureau Olivier , Audouze Karine 
Published: December 2021

Background: The chemical part of the exposome, including drugs, may explain the increase of health effects with outcomes such as infertility, allergies, metabolic disorders, which cannot be only explained by the genetic changes. To better understand how drug exposure can impact human health, the concepts of adverse outcome pathways (AOPs) and AOP networks (AONs), which are representations of causally linked events at different biological levels leading to adverse health, could be used for drug safety assessment.Methods: To explore the action of drugs across multiple scales of the biological organization, we investigated the use of a network-based approach in the known AOP space. Considering the drugs and their associations to biological events, such as molecular initiating event and key event, a bipartite network was developed. This bipartite network was projected into a monopartite network capturing the event–event linkages. Nevertheless, such transformation of a bipartite network to a monopartite network had a huge risk of information loss. A way to solve this problem is to quantify the network reduction. We calculated two scoring systems, one measuring the uncertainty and a second one describing the loss of coverage on the developed event–event network to better investigate events from AOPs linked to drugs.Results: This AON analysis allowed us to identify biological events that are highly connected to drugs, such as events involving nuclear receptors (ER, AR, and PXR/SXR). Furthermore, we observed that the number of events involved in a linkage pattern with drugs is a key factor that influences information loss during monopartite network projection. Such scores have the potential to quantify the uncertainty of an event involved in an AON, and could be valuable for the weight of evidence assessment of AOPs. A case study related to infertility, more specifically to “decrease, male agenital distance” is presented.Conclusion: This study highlights that computational approaches based on network science may help to understand the complexity of drug health effects, with the aim to support drug safety assessment.
Stressful Life Events and Chinese Older People Depression: Moderating Role of Social Support
Authors: Yu Xiao , Liu Shu 
Published: December 2021

Aim: This study analyzes the effects of retrospective stressful life events on current depression among Chinese older people and how these effects are moderated by social support. Stressful life events comprise bereavement, divorce, health adversities, accidents, and financial losses due to fraud.Data and Method: Data were drawn from the China Health and Retirement Longitudinal Study (CHARLS) of the 2015 panel, and responses from 9,619 older people aged over 60 years were used. The least-squares regression method was applied to measure the linear effects. Propensity score matching minimized selection bias and enabled the measurement of the net effects of stressful life events. The bias-corrected matching estimator was also used to correct the inexact matching bias from propensity score matching.Result: Experienced stressful life events and exposure to cumulative stressful life events were found to lead to depression in older people. When older people experienced stressful life events but with more social activities, and higher satisfaction and frequent contact with children, their depressive levels were lower. The results of the propensity score matching showed that stressful life events resulted in depression in older people. Furthermore, individuals with family support were able to moderate stressful life events effects; however, the moderating effects of social activity separately were negligible. In sum, with the moderating role of family support and social activity, the average differences in older people depression caused by stressful life events decreased.Conclusion: Experiencing stressful life events is detrimental to the psychological health of the older people. Social support, including family support and social activity, has buffered detrimental effects on depression caused by stressful life events.Interpretations: The study underscores the need to supply effective interventions for the older people who experienced stressful life events. First, society should improve the capability of community care centers to supply mental health services. Second, family members should pay attention to mental condition of older people, and specific support should concord with the needs of Chinese older people. In addition, support suppliers can move from being confined to kinship relationships to close relationships, such as the community partners and neighbors.
Increased Risk of Hospital Admission for Asthma in Children From Short-Term Exposure to Air Pollution: Case-Crossover Evidence From Northern China
Authors: Zhao Yakun , Kong Dehui , Fu Jia , Zhang Yongqiao , Chen Yuxiong , Liu Yanbo , Chang Zhen'ge , Liu Yijie , Liu Xiaole , Xu Kaifeng , Jiang Chengyu , Fan Zhongjie 
Published: December 2021

Background:Previous studies suggested that exposure to air pollution could increase risk of asthma attacks in children. The aim of this study is to investigate the short-term effects of exposure to ambient air pollution on asthma hospital admissions in children in Beijing, a city with serious air pollution and high-quality medical care at the same time.Methods:We collected hospital admission data of asthma patients aged ≤ 18 years old from 56 hospitals from 2013 to 2016 in Beijing, China. Time-stratified case-crossover design and conditional Poisson regression were applied to explore the association between risk of asthma admission in children and the daily concentration of six air pollutants [particulate matter ≤ 2.5 μm (PM2.5), particulate matter ≤ 10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3)], adjusting for meteorological factors and other pollutants. Additionally, stratified analyses were performed by age, gender, and season.Results:In the single-pollutant models, higher levels of PM2.5, SO2, and NO2were significantly associated with increased risk of hospital admission for asthma in children. The strongest effect was observed in NO2at lag06 (RR= 1.25, 95%CI: 1.06-1.48), followed by SO2at lag05 (RR= 1.17, 95%CI: 1.05–1.31). The robustness of effects of SO2and NO2were shown in two-pollutant models. Stratified analyses further indicated that pre-school children (aged ≤ 6 years) were more susceptible to SO2. The effects of SO2were stronger in the cold season, while the effects of NO2were stronger in the warm season. No significant sex-specific differences were observed.Conclusions:These results suggested that high levels of air pollution had an adverse effect on childhood asthma, even in a region with high-quality healthcare. Therefore, it will be significant to decrease hospital admissions for asthma in children by controlling air pollution emission and avoiding exposure to air pollution.
PROSPECTS FOR EXPANDING THE RAW MATERIALS FOR THE PRODUCTION OF MODERN CONSTRUCTION COMPOSITES
Authors: Аласханов А. Х. 
Published: December 2021

В работе приводятся возможности расширения сырьевой базы для получения качественных и прочных строительных композитов. Приводится понятие о ресурсном цикле, основанном на природном круговороте веществ (ПКВ) и обеспечивающем безотходный замкнутый цикл производства композитов. Обозначена актуальность и перспективность перехода на энерго- и ресурсосберегающие технологии безотходного производства.
The paper presents the possibilities of expanding the raw material base to obtain high-quality and durable building composites. The concept of a resource cycle based on the natural cycle of substances (PCR) and providing a waste-free closed cycle for the production of composites is given. The relevance and prospects of the transition to energy- and resource-saving technologies of waste-free production are indicated.
Model Pengambilan Keputusan Berwisata
Authors: Rachmadi Hari 
Published: December 2021

The travelling decision model reflects the Characteristics and type of travel. It differentiates and compares the tendencies of decision-making behaviour in different situational. The Travelling decision is established by the different motives of each individualand group. Where the situational factor affects the behaviour of decision making. Most of the decision-making processes require the involvement of behaviour in using the information like in contemporary decision making. one of the examples is the decision to travel. The logical decision making is the decision made through clear steps that reflects the different characteristics of behaviour in specific decision situations which the values are related and chosen tourist destination are suitable and desirable
Symbolizm społeczny w biografii Jana Pawła II
Authors: Walancik Marek 
Published: December 2021

Symbolem może być rzecz, gest, wyraz twarzy, mniej lub bardziej złożone działanie człowieka, symbolem może być historia jednostki czy grupy, może nim być człowiek, postać. Szczególnego znaczenia nabiera, symbolizm społeczny w działaniach zbiorowych. Artykuł zawiera wybrane formy symbolizmu z pontyfikatu Jana Pawłą II.
Chiara „Luce” Badano
Authors: Łobacz Małgorzata 
Published: December 2021

Młodzi ludzie w dzisiejszej rzeczywistości czują się coraz bardziej zagubieni moralnie i duchowo. Takiej sytuacji niewątpliwie sprzyja brak uniwersalnych wartości, filarów, na których opierają się określone wzorce i modele zachowań, a także obecny indywidualizm i pluralizmu zasad, subiektywizm wartości i norm. W obliczu tych zagrożeń szczególną rolę odgrywają wzory osobowe, które mogą zainspirować do wybierania drogi „pod prąd”, poszukiwania tego, co prawdziwie jest wartościowe. W niniejszym artykule odwołałam się do świadectwa życia Chiary „Luce” Badano – Błogosławionej Nastolatki, patronki młodzieży, współczesnej świętej. Dziedzictwo, które pozostawiła po sobie – w postaci przykładu krótkiego, ale duchowo bogatego życia – nieustannie jest odkrywane przez dzisiejszych nastolatków i stanowi inspirację do podejmowania wysiłku, by wzrastać duchowo i moralnie, bardziej „być” niż „mieć”, a tym samym potwierdzić swoją osobową godność, być osobą nie tylko na płaszczyźnie ontologicznej, ale stać się nią faktycznie.
Pedagogiczny charyzmat Sługi Bożego Ks. Luigiego Giussaniego (1922-2005)
Authors: Rynio Alina 
Published: December 2021

Niniejsza publikacja przybliża wielorako manifestującą się charyzmatyczną działalność pedagogiczną znanego ze swych licznych dokonań włoskiego nauczyciela i wychowawcę, ks. Luigiego Giussaniego. Bez wątpienia człowiek ten ze względu na swą wyjątkową wnikliwość i odwagę był postacią znaną i cenioną nie tylko w życiu uniwersyteckim, kościelnym ale także szkolnym, kulturalnym i politycznym.
Autorka opracowania uwzględniając aspekt pedagogiczny zwraca uwagę na Giussaniego jako wyjątkowego nauczyciela i wychowawcę. Przybliża jego sposób rozumienia pedagogiki i wychowania a prezentując z jego biografii wybrane dokonania, potwierdza jego wyjątkowość. Jako nauczyciel i wychowawca ks. Giussani odznaczał się trzeźwym i realistycznym spojrzeniem na człowieka i jego wychowanie. Podkreślając wartość osoby jako istoty rozumnej i wolnej jego postawa charakteryzowała się całkowitym zawierzeniem Bogu i wielką miłością do każdego spotkanego człowieka.
Publikacja zawiera krótki rys biograficzny, opisuje preferowane przez Giussaniego sposoby wychowania, zdarzenia wychowujące, elementy konstytuujące osobowość wychowującego i wychowywanego jak również ukazuje związek wychowania z wolnością, sumieniem i tradycją.