bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Peripheral Neuropathic Pain among Adult Diabetic Patients (T2DM) with Peripheral Neuropathy and Quality of Life of the Patients with Peripheral Neuropathic Pain
Authors: Abu-Shennar Jawad Ahmad , Bayraktar Nurhan , Bebis Hatic 
Published: March 2021

Abstract
Aim The aim of the study was to assess the prevalence of diabetic peripheral neuropathic pain (DPNP) among adult patients suffering from type 2 diabetes mellitus (T2DM) with diabetic peripheral neuropathy (DPN) as well as to determine the quality of life of patients with DPNP.Materials and method The study designed in cross-sectional research model was conducted at the Jordanian Ministry of Health in Jordan, Amman during the period from 15 June 2019 to 5 October 2019. A total of 400 adult T2DM patients with DNP were recruited for the study. Data were collected by way of an assessment tool package, including descriptive data (demographics, anthropometric measurements, laboratory measurements, and clinical data), the Douleur Neuropathique4 (DN4) questionnaire, physical exam, Quality of Life Questionnaire (EQ-5D), and Numeric Pain Rating Scale (NRS). To analyze study data descriptive and inferential statistics were used.Results Results of the current study showed that the prevalence of DPNP among adult T2DM patients with DPN was high (47.8%). About half of the participants had mild or moderate pain with the most frequently reported symptoms of tingling and burning. Uncontrolled diabetes was found to be the main predictor of DPNP among patients with DPN. Participants who had DPNP reported having problems in connection with mobility, self-care, routine activities, discomfort, and anxiety or/and depression, and they had a significantly lower quality of life with poorer self-rated health status than those without DPNP. Besides, the effect of pain on their quality of life was found to be significant.Conclusion The study recommends, in accordance with the results, that strategies should be developed for an effective management of painful DPN with an integrated and interdisciplinary approach. Current clinical guideline recommendations should be followed to improve patient care and reduce the burden of the disease.
Quality of Life and Associated Factors Among Women With Obstetric Fistula in Ethiopia
Authors: Matiwos Biruktawit , Tesfaw Getachew , Belete Asmare , Abebaw Dessie , shumet shegaye 
Published: March 2021

Abstract
Background: The physical, emotional and social suffering associated with continuous leakage of urine has a profound impact on women quality of life. The aim of this study was to assess quality of life and associated factors among obstetric fistula patients in Ethiopia, has a significant role for further intervention. Objective: To assess quality of life and associated factors among obstetric fistula patients in Ethiopia, 2017. Methods: In this cross-sectional study, 289 women with obstetric fistula were recruited for interviews, using the systematic random sampling technique. The World Health Organization Quality of Life – Brief (WHOQOL-BREF) Version was used to assess quality of life. The Jacob perceived stigma scale and the Oslo-3 social support instruments were used to assess the factors. We computed simple and multiple linear regression analysis to assess factors associated with quality of life. P-value <0.05 was declared statistically significant.Result: Of 289 women studied, only 12.1% felt satisfied with their general state of health and quality of life. In the physical health domain, the mean quality of life score was 40.78±.78. In the psychological domain, the mean quality of life score was 39.96±.82. In the social and environmental domain, the mean quality of life score was 32.9±.95, 36.45±.8 respectively. Duration of incontinence (unstandard β=-3.8,95% CI(-6.95,-.62), patients coming for surgical procedure (β=-4.4, 95% CI(-7.64,-1.2), poor social support(β= -6.14, 95%CI (-8.8,-3.4), Co-morbid anxiety(β= -4, 95% CI (-7,-1.1) and depression(β=-9.2, 95% CI (-12,-6.4) were negatively associated with physical domain of quality of life. Co-morbid anxiety (β= -11,95% CI (-14.8,-7.3), employment(β= 9.1,95%CI(.5, 17.6), number of children(β= 2.1,95%CI(.8, 3.4), and depression(β= -6.3,95%CI(-9.7,-2.9) were associated with a psychological domain. Duration of incontinence (β=-8.1,95%CI(-12.82,-3.4), poor social support(β= -7.8(-12,-3.6), patients coming for surgical procedure (β= -12,95%CI(-17.4,-6.4) and co-morbid anxiety(β= -9.2,95%CI(-13.8, 4.5) were negatively associated with social domain of quality of life. Number of children present (β=2.4,95%CI(.82, 3.6), and poor social support(β= -5.5,95%CI(-9.5,-1.5) were significantly associated with an environmental domain of quality of life. Conclusion and recommendation: Co-morbid depression and anxiety, poor social support, duration of urine incontinence, employment, number of children, and duration of hospital stay were factors significantly associated with domains of QOL. Treating co-morbid depression and anxiety, strong social support and controlling urine incontinence is necessary to increase women’s domain of quality of life.
Emotional Eating in Adults: the Role of Socio-demographics, Lifestyle Behaviors, and Self-regulation- Findings From a US National Study
Authors: Barak Roni Elran , Shuval Kerem , Li Qing , Oetjen Reid , Drope Jeffrey , Yaroch Amy L. , Fennis Bob M. , Harding Matthew 
Published: March 2021

Abstract
The authors have requested that this preprint be withdrawn due to erroneous posting.
Depressive symptoms in mothers with infants: The quantitative evidence of the association of COVID-19 crisis-related factors in Japan
Authors: Matsushima Midori , Horiguchi Hanna 
Published: March 2021

Abstract
Objective: This study explores the depressive symptoms in postpartum women during the coronavirus disease (COVID-19) crisis in Japan.Methods: An online survey conducted from 31 May to 6 June, 2020 resulted in 3,073 responses obtained from mothers with infants < 12 months. Results: The point prevalence of the Edinburgh Postnatal Depression Scale (EPDS) score of ≥ 9 was 28.66% for primipara and 25.83% for multipara. Logistic regression analysis indicated a negative association between the COVID-19 crisis and EPDS ≥ 9; specifically, decreased social support and financial concern were identified as risk factors. The COVID-19 related experiences significantly increased the score of each factor of EPDS, i.e., anxiety, anhedonia, and depression.Conclusions: During the COVID-19 crisis, the number of mothers who faced depreciation in social support and income had increased. Moreover, spending their perinatal period during the crisis increased the propensity of facing unexpected changes, such as changes of hospitals for delivery, or cancellation of parenting classes. These multiple factors were associated with an elevated risk of depression in postpartum women. In a prolonged crisis, postpartum mental health should be treated carefully with the prevention of infection.
Effect of an unifaceted and multifaceted intervention on antibiotic prescription control for respiratory diseases: a systematic review of randomized controlled trials
Authors: Yue Chang , Cui Zhezhe , Yang Guanghong , He Xun , Wang Lei , Xin Zhang , Tang Lei 
Published: March 2021

Abstract
Background The global health system is improperly using antibiotics, particularly in the treatment of respiratory diseases. We aimed to examine the effectiveness of implementing an unifaceted and multifaceted intervention for unreasonable antibiotic prescriptions.
Methods Relevant literature published in the databases of Pubmed, Embase, Science Direct, Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Journal Full-text (CNKI) and Wanfang was searched. Data were independently filtered and extracted by two reviewers based on a pre-designed inclusion and exclusion criteria. The Cochrane collaborative bias risk tool was used to evaluate the quality of the included studies.
Results A total of 1,074 relevant studies were obtained of which 69 were included in the systematic review. Fifty-nine studies reported positive results, that is, the primary results in the intervention groups were superior to those in the control groups. The remaining 10 studies had negative or partially negative results. In 22 studies the outcome variable was the antibiotic prescription rate with detailed reports of the number of prescriptions being further analyzed, of which 19 involved educational interventions for doctors, including: (1) Online training using email, web pages and webinar, (2) Antibiotic guidelines for information dissemination measures by email, postal or telephone reminder, (3) Training doctors in communication skills, (4) Short-term interactive educational seminars, and (5) Short-term field training sessions. Seventeen studies of interventions for health care workers also included: (6) Regular or irregular assessment/audit of antibiotic prescriptions, (7) Prescription recommendations from experts and peers delivered at a meeting or online, (8) Publicly reporting on doctors' antibiotic usage to patients, hospital administrators, and health authorities, (9) Monitoring/feedback prescribing behavior to general practices by email or poster, and (10) Studies involving patients and their families (n=10). Seventeen studies were rated as having a low risk of bias while five were rated as having a high risk of bias.
Conclusion The combination of education, prescription audit, prescription recommendations from experts, public reporting, prescription feedback and patient or family member multiple interventions can effectively reduce antibiotic prescription rates in health care institutions. Moreover, adding multiple interventions to educational interventions interventions can control antibiotic prescription rates and may be a more reasonable method.
Registrations: This systematic review was registered in PROSPERO, registration number: CRD42020192560.
Keywords: Randomized controlled trial, Respiratory diseases, Antibiotic prescriptions, Systematic evaluation
Aktualny stan wiedzy w zakresie leczenia interdyscyplinarnego chłoniaków w oparciu o informacje pozyskane na konferencji ASTR0’S 56-th Annual Meeting.
Authors: Rucińska Anna 
Published: March 2021

Radioterapia wąską wiązką elektronów skóry całego ciała jest skuteczną metodą leczenia chorych na ziarniniaka grzybiastego. Leczenie dawką konwencjonalną 36 Gy wiąże się z wielotygodniową hospitalizacją i stosunkowo dużą toksycznością leczenia. Na ASTRO 56 przedstawiono wyniki trzech badań prospektywnych drugiej fazy oceniające skuteczność i bezpieczeństwo leczenia niską dawką całkowitą.
Local water resource management through stakeholder participation: case study, arid region, India
Authors: Sheth Dhwani , Iyer Mona 
Published: March 2021

Abstract
Access to clean water is important for socio-economic development worldwide. Bhuj, in an arid region in Gujarat State in India, has an ancient and unique water resource management system. The city's visionary king developed a catchment system of lakes so that, despite minimal rainfall and frequent droughts, sufficient water could be stored to sustain the city for around 300 years. However, over the years, with rapid urbanization and the introduction of a piped water supply, this ancient supply system was abandoned and was not maintained well. As a result, the city's water resources became polluted and defunct, which forced it to depend on distant water sources. This study shows how the city's water management strategies changed before independence (1947), and pre-earthquake (1947–2001) and post-earthquake (2001 to present). The paper mainly documents how the city's own water resources can be managed successfully by following the concepts of IUWM through effective stakeholder participation, to make the city water-secure.
A new effective way to degrade methylene blue by introducing negative ions powder into Fe3O4/H2O2 system to accelerate Fe(III)/Fe(II) transformation
Authors: Zhang Xiangfen , Wu Hanxin , Ke Zunye , Yang Jiafei , Chen Hongzhou , Xue Feng , Ding Enyong 
Published: March 2021

Abstract
Negative ions powders (NIP) have been widely applied in many fields because of their natural electric field and far infrared radiation, especially in wastewater treatment. In this study, the NIP was first introduced into Fe3O4/H2O2 system to degrade methylene blue (MB). The MB removal was completely achieved at 5 h via a non-photochemical pathway and the degradation rate constant of this system is about 0.565 h−1, which is about 16 times higher than in Fe3O4/H2O2 Fenton-like system (0.035 h−1). In addition, the results of quenching experiments indicate that the electron (e−) and negative oxygen ion (•O2−) are the main reactive species. It was determined that Fe3O4@NIP is the effective component that leads to the activation of H2O2 to produce •OH, which derive from the pathway: NIP acts as an electron donor to reduce Fe(III) into Fe(II). Moreover, NIP can produce negative ions, which is also conductive to degradation. This study suggests a promising direction for the practical application of NIP based catalysis by integrating it with the Fe(III)/Fe(II) transformation process.
A Review Study about the Effect of Chitosan Nanocarrier on Improving the Efficacy of Amphotericin B in the Treatment of Leishmania from 2010 to 2020
Authors: Mehrizi Tahereh Zadeh , Rezayat Seyed Mahdi , Ardestani Mehdi Shafiee , Shahmabadi Hasan Ebrahimi , Ramezani Amitis 
Published: March 2021

:
In the present review study, the published articles from 2010-2020 that evaluated the effect
of chitosan nanocarrier on the efficacy of amphotericin B (AmB) in the treatment of leishmaniasis,
have been considered. Leishmania is a parasitic tropical disease in the world and is treated
with AmB as one of the main therapeutic agents. However, the clinical application of AmB is limited
due to its toxicity and insolubility issues. Using nanoparticles and, in particular, chitosan, nanocarrier
seems a promising approach to overcome these problems. Therefore, various doses of AmB
have been loaded in chitosan nanoparticles in different studies and the results of these studies demonstrated
that by increasing the drug loading efficiency and decreasing the toxicity, the potency
of the nanoformulation to inhibit and to kill the parasite is increased. In this regard, the results of a
study performed in 2018, demonstrated that chitosan nanoparticles with the higher dose of drug
loading were the most effective formulation to inhibit and kill the parasite. Thus, chitosan nanocarrier
can consider as an appropriate candidate in the future to inhibit and kill the Leishmania parasite
without causing side effects
Physical and Mental Functions of Cardiovascular Diseased Patients Decrease During the State of Emergency Initiated by the COVID-19 Pandemic in Japan
Authors: Ishihara Kodai , Izawa Kazuhiro P. , Noto Shinichi , Shimizu Ikki 
Published: March 2021

Background and Objective:
We aimed to examine the differences in life-space mobility
and quality of life (QoL) of patients with cardiovascular disease (CVD) between the pre- and postnationwide
state of emergency initiated by the Coronavirus disease 2019 (COVID-19) pandemic in
Japan and to show the factors associated with the decrease in life-space mobility and QoL in these
patients.

Methods:
We undertook a longitudinal study of 20 out of 51 consecutive CVD patients with coronary
artery disease (CAD) who met the study criteria. We used the Life-Space Assessment (LSA)
tool to evaluate Life-space mobility and assessed QoL with the five-level EuroQoL five-dimensional
questionnaire (EQ-5D-5L) in Japanese.

Results:
The LSA scores and EQ-5D-5L QoL score decreased significantly from the pre- to postnationwide
state of emergency in Japan (p < 0.01). ΔLSA was significantly positively associated
with body mass index and significantly negatively associated with knee extensor muscle strength
and pre-LSA score (p < 0.05). There were no significant relationships between ΔLSA and ΔEQ-
5D-5L QoL scores and between ΔEQ-5D-5L QoL scores and patient characteristics.

Conclusion:
The policies promoted to address the state of emergency in Japan might affect life-space
mobility and QoL of CAD patients. Moreover, CAD patients in Japan who were not obese
and maintained their physical function and activity tended to refrain from activity during the period
between the pre- and post-nationwide state of emergency. Clarification of the effects of the
COVID-19 pandemic on the relationship between living space motility and QoL in CAD patients
will require further study.
Technological Maturity and Systematic Review of Medicinal Plants with Pharmacological Activity in the Central Nervous System
Authors: Bastos Eduardo M.S. , da Silva Victor D.A. , Costa Silvia L. , Hanna Samira A. 
Published: March 2021

Background:
Medicinal plants present activities against neurodegenerative diseases
with potential for the pharmaceutical industries. Therefore, the objective of this
study was to investigate the current panorama of patents and articles of Brazilian medicinal
plants with pharmacological activities in the Central Nervous System (CNS), regarding
such aspects as the number of patents by countries, areas of knowledge, and technological
maturity.

Method:
We carry out a technological exploration on the Questel Orbit® platform with
the descriptors: Agave sisalana P., Amburana cearenses A., Dimorphandra mollis B., Jatropha
curcas L., Poincianella pyramidalis T. and Prosopis juliflora (Sw.) DC. with pharmacological
activity and scientific exploration in PubMed and Science Direct associated
with the CNS in the title, abstract, and methodology.

Results:
A total of 642 patents were identified between the years 1999-2019. India, China,
and Brazil are highlighted, 6th place, out of a total of 48 countries. Of these, 30 patents
were not in the National Institute of Industrial Property, and 10% are Brazilian in
biotechnology and pharmaceutical products. Eleven articles were used in PubMed and
Science Direct with scientific domains (anticancer, neuroprotection and anti-inflammatory).
The Federal University of Bahia is highlighted, showing Technology Readiness Levels
(TRL4), basic skills of pre-clinical research.

Conclusion:
Brazilian public universities have a significant role in the scientific, technological
and innovative development of therapeutic assets for CNS.
Validating the Arabic Scale of Happiness among College Students
Authors: Dodeen Hamzeh M. , Cody Brettjet L. 
Published: March 2021

Background:
Happiness is well known to have positive consequences not only on one person but also on society as a whole. For this reason, psychologists have become increasingly interested in positive psychology in general and in happiness in particular. This interest has been reflected in studying happiness and measuring it. Thus, questions raised lately about the best methods or producers and tools to accurately measure it. And, because happiness is a culturally influenced construct, the applicability of such tools needs to be verified across cultures.

Objectives:
The study aimed at assessing the reliability and validity of the Arab Scale of Happiness (ASH). The study was conducted on college students, and the analysis included testing of several statistical analyses such as the correlations between two tools for measuring happiness, namely, the Oxford Happiness Questionnaire (OHQ) and Satisfaction With Life Scale (SWKS), and Beck Depression Inventory (BDI-II).

Methods:
A total of 731 college students from a public university in UAE were recruited for the tests used in the study. The validation process of the ASH included assessing its factor structure using both exploratory factor analysis and confirmatory factor analysis. Convergent validity, discriminant validity, and internal reliability of the scale were assessed and reported in addition to evaluating gender differences.

Results:
Results indicated that the ASH is unidimensional, with a dominant factor explained more than 50% of the variance. The internal reliability of the ASH was high (α= .93), and all items performed properly in measuring happiness. The scale has a good convergent validity as it is highly and positively correlated with OHQ and SWLS, and good discriminate validity as its highly and negatively correlated with BDI-II.

Conclusion:
The ASH is a reliable and valid scale for measuring happiness among youth and college students. It is necessary to establish its appropriateness for use across populations or countries in future studies. Furthermore, the scale can be used in cross-cultural applications to assess happiness among different groups of individuals.
Burden and Depression among Jordanian Caregivers of Hemodialysis Patients: A Cross-sectional Study
Authors: Alnazly Eman Khamis 
Published: March 2021

Introduction:
Caring for patients receiving hemodialysis places a burden on caregivers.

Objectives:
To examine caregiving burden and depression in the family caregivers of patients receiving hemodialysis and associated factors.

Methods:
A cross-sectional design was used. Participants were 204 adult caregivers of patients receiving hemodialysis. Questionnaires included sociodemographic characteristics, the Oberst Caregiving Burden Scale-Difficulty (OCBS-D) subscale, Bakas Caregiving Outcomes Scale (BCOS), and the Patient Health Questionnaire-9 to measure the burden and depression of caregivers. Descriptive statistics, two linear regression analyses, and multinomial logistic regression were used in data analysis.

Results:
The majority (59.0%, n = 120) of caregivers had a moderate level of depression with scores ranging from 11 to 16. The analysis showed that the mean score of OCBS-D was 42.0 (SD = 4.7) with scores ranging from 26.9 to 58.9 (range = 32.0), while the caregivers' mean score of BCOS was 52.1 (SD = 9.3) with scores ranging from 38.0 to 82.5 (range = 44.5). Given that the expected score of OCBS-D and BCOS ranged from 15 to 75 and 15 to 105, respectively, the analysis indicated a moderate to a high level of burden among caregivers. Age and travel time were associated with a higher likelihood of negative outcomes in the family caregivers, while higher patient age was associated with a greater caregiver burden.

Relevance to Clinical Practice:
It is important to assess and address the practical issues that caregivers experience, such as employment-related responsibilities, financial difficulties, and the need to learn specific skills related to patients’ chronic illnesses.

Conclusion:
Caregivers of patients receiving hemodialysis are likely to experience moderate depression and burden. Caregiver burden increases with patient age and travel time to the hemodialysis units.