bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selection of the optimal dosage of tranexamic acid to reduce blood loss during pediatric cleft palate surgery
Authors: Shafa Amir , Shetabi Hamidreza , Adineh-Mehr Lili , Bahrami Keivan 
Published: March 2021

Objective:
The aim of the present study was to evaluate and select the optimal dosage of tranexamic acid (TXA) to reduce blood loss during cleft palate surgery in children.

Materials and Methods:
This randomized double-blind clinical trial was performed on 80 children under 3 years of age that were candidates for cleft palate surgery. These children were divided into four groups as follows: the first, second, and third groups received 5, 7.5, and 10 mg/kg of TXA, respectively. Moreover, the fourth group was considered as the control group. Before induction of anesthesia and then every 15 min during the surgery, some parameters such as mean arterial pressure, heart rate, SpO2, and ETCO2 were recorded. Moreover, the amount of blood loss during the surgery, the level of surgeon's satisfaction, and incidence rate of complications were assessed and recorded.

Results:
The amount of blood loss during the surgery in TXA groups receiving dosages of 5, 7.5, and 10 mg/kg with the means of 63.75 ± 10.62, 61.25 ± 15.03, and 61.00 ± 14.29, respectively, was significantly lower than that of the control group with the mean of 92.25 ± 19.83 (P < 0.001). Moreover, no significant difference was found between the three groups receiving TXA dosages in terms of the amount of blood loss, the level of surgeon's satisfaction (P > 0.05).

Conclusion:
According to the results of the present study, all three dosages of TXA had a significant role in reducing blood loss in cleft palate surgery. Given the potential for increased risk of side effects from the drug, it seems safe to use the minimal dosage of this drug to control and reduce blood loss during cleft palate surgery in children <3 years of age.
LEGAL AUDIT QUALITY AND FRAUD RISK: THE CASE OF TUNISIAN LISTED COMPANIES
Authors: Lajmi Azhaar , Khiari Wided , Ouertani Oumaima 
Published: March 2021

The aim of this study is to examine the impact of legal audit quality on the likelihood of accounting fraud, for a sample of 48 companies listed on the Tunisian stock market over the period between 2014 and 2018. Based on the logit panel regression, we have shown that the audit firm's membership in one of the Big networks and the rotation of external auditors are two major determinants in the reduction of cases of fraud in Tunisian companies. In addition, the results showed that joint audit deteriorates the quality of auditing and thus increases the risk of fraud. This study provides new insights in terms of legal audit and fraud risk in the Tunisian context based on the econometrics of panel data, which is a valuable method to measure the impact of several actions alone or simultaneously. It has allowed us to analyze the behaviors of companies by considering the effect of many proxies of legal audit quality.
JEL Classification Codes: G32, M42, C23.
¿«AVASALLA» LA SALA 3.ª DEL TRIBUNAL SUPREMO AL CONSEJO GENERAL DEL PODER JUDICIAL? (DE NUEVO SOBRE EL CONTROL JUDICIAL DE LA DISCRECIONALIDAD)
Authors: IGARTUA SALAVERRIA JUAN 
Published: March 2021

Este comentario se centra en el análisis del voto particular a una
sentencia del Tribunal Supremo que anuló un nombramiento discrecional del
Consejo General del Poder Judicial. Se examinan críticamente los argumentos
del voto desde un punto de vista teórico-general y no en lo que atañen a las particularidades
del caso (si bien inicialmente se ofrece una semblanza de éste para
hacer comprensibles los términos de la discusión). Las consideraciones críticas
giran en torno a los siguientes temas: la necesidad de la motivación sustancial
(no sólo formal) en los nombramientos discrecionales, el incorrecto planteamiento
de la dicotomía «nombramiento discrecional» ¿ «concurso de méritos»,
la motivación contextualizada, la discrecionalidad no es simple libertad, errónea
importación de dos elementos procesales (valoración conjunta e inmediación),
distinta metodología de valoración según el planteamiento sea de «todo o nada»
o de «más o menos».
Botere Judizialaren Kontseilu Nagusiaren izendapen diskrezional
bat indargabetu zuen Auzitegi Gorenaren epai bati emandako boto partikularra
da iruzkin honen ardatza. Kritikoki aztertzen dira botoaren argudioak, ikuspuntu
teoriko-orokorretik, eta ez kasuaren berezitasunei dagokienez (dena dela, hasieran
kasuaren azalpena ematen da, eztabaidaren nondik norakoak ulergarriak izan
daitezen). Gogoeta kritikoen ardatzak honako gai hauek dira: izendapen diskrezionaletan
funtsezko arrazoiak (eta ez soilik formazko arrazoiak) emateko beharrizana,
«izendapen diskrezionala»- «meritu-lehiaketa» dikotomiaren planteamendu okerra,
testuinguru eta guztiz arrazoitzea, diskrezionalitatea ez da askatasun hutsa, prozesu-
elementu biren (baterako balorazioa eta hurrekotasuna) inportazio okerra, planteamendua
«dena ala ezer ez» edo «gehiago ala gutxiago» den kontuan hartuta
baloraziorako metodologia diferentea erabiltzea.
This article focuses on analyzing an individual opinion to a
Supreme Court¿s ruling that annulled a discretional appointment to the General
Council of the Judiciary. The arguments in that opinion are critically observed
from a general-theoretical point of view and not from the standpoint of the
particularities of the case (even though at the beginning a profile of it is given in
order to make the terms of the issue comprehensible). The critical considerations
turn on the following subjects: the necessity of a substantive motivation (not
only a formal one) in discretional appointments, the faulty approach within
the dichotomy between «discretional appointment» ¿ «merit competition», the
contextual motivation, discretion is not mere freedom, the inaccurate importation of two procedural elements (joint assessment and immediacy), the different
methodology used in the assessment depending on the «all or nothing» or «more
or less» approach.
EL PRINCIPIO DE AUTONOMÍA LOCAL EN EL RÉGIMEN VASCO DEL GOBIERNO LOCAL
Authors: PAREJO ALFONSO LUCIANO 
Published: March 2021

Este trabajo comienza por precisar el planteamiento a que responde
el régimen legal vasco del gobierno local, los términos de su inserción
en el marco constitucional y legal estatal (interpretado correctamente de forma
amplia y comprensiva, por tanto, de las previsiones tanto de la Carta Europea de
Autonomía Local, como del Derecho originario de la Unión Europea) y la consecuente
función que está destinado a cumplir en la peculiar organización territorial
de Euskadi, para identificar seguidamente el pleno desarrollo del principio
de autonomía local como objetivo fundamental del legislador vasco y precisar
las consecuencias de tal objetivo en el estatuto del gobierno local que define.
Sobre esta base analiza la concepción de la autonomía local en la que descansa
y a la que el mismo responde para concluir con la exposición de los novedosos
mecanismos preventivos que pone al servicio de la garantía de la efectividad de
la referida autonomía.
Lan honen hasieran toki-gobernuaren EAEko araubide legalari
dagokion planteamendua zehaztu da, baita estatu mailako esparru konstituzionalean
eta legalean txertatzeko baldintzak ere (modu zabal eta ulergarrian interpretatuz
bai Tokiko Autonomiaren Europako Gutunaren, bai Europar Batasuneko jatorrizko
eskubidearen aurreikuspenak); planteamendu horrek, ondorioz, Euskadiko
lurralde-antolaketa berezian bete beharko duen funtzioa ere aztertu da; jarraian,
toki-autonomiaren printzipioaren erabateko garapena identifikatu du, EAEko legelariaren
funtsezko helburu gisa, eta definitutako toki-gobernuaren estatutuan
helburu horrek izango lituzkeen ondorioak argitu ditu. Oinarri horretatik abiatuta
tokiko autonomiaren kontzepzioa aztertu du, eta horri erantzuten dio; bukatzeko,
aipatutako autonomiaren eraginkortasuna bermatzeko baliatutako prebentzio-mekanismo
berritzaileak azaldu ditu.
This paper aims at specifying the legal system rationale for
the Basque Country¿s local government, the terms of its insertion within
the Constitutional and legal framework at the National level ¿with a broad
interpretation, including, therefore, both, the European Charter of Local Self-
Government, and the European Primary Law-, and the resulting role this legal
system has to play in the special territorial organization of Euskadi. Following
that, the paper tries to identify the full development of the principle of local
self-government as the main objective of the Basque legislator, indicating its
consequences within the local government statute defined by it. On this basis, the paper analyzes the local self-government conception of the principle previously indicated, and concludes outlining new preventive mechanisms that are placed in
the service of the referred self-government effectiveness.
EL ESTATUTO DE LOS ELECTOS LOCALES
Authors: ALONSO HIGUERA CARMEN 
Published: March 2021

El objeto de este trabajo radica en analizar el conjunto de derechos,
prerrogativas, deberes y responsabilidades que integran el estatuto jurídico
del electo local en la actualidad, determinando previamente la especial configuración
de su marco legal, para después analizar sucesivamente el contenido exhaustivo
de este estatuto en la legislación básica estatal y su eventual interpretación
por la Jurisprudencia del Tribunal Supremo y del Tribunal Constitucional, las especialidades
derivadas de la legislación autonómica vasca y, finalmente, el importante
papel que pueden tener en esta labor los Reglamentos Orgánicos locales.
Lan honen helburua gaur egun toki-hautetsiaren estatutu juridikoa
integratzen duten eskubide, prerrogatiba, betebehar eta erantzukizunen
multzoa aztertzea da, aldez aurretik lege-esparruaren osaera berezia zehaztuz eta,
ondoren, estatutu horren eduki zehatza aztertuz estatu mailako oinarrizko legedian
eta Auzitegi Gorenaren eta Auzitegi Konstituzionalaren jurisprudentziaren balizko
interpretazioan, eta EAEko legedi autonomikotik eratorritako espezialitateak aintzat
hartuz: azkenik, tokiko erregelamendu organikoek betebehar horretan izan dezaketen
funtzio garrantzitsua jorratu da.
The scope of this work lies in analyzing the bundle of rights,
prerogatives, duties and responsibilities that at present are part of the legal status
of the local elected members, by previously determining the special configuration
of their legal frame and then successively analyzing the exhausting content of this
status in the State basic legislation and its possible interpretation by the Supreme
and Constitutional courts case law, the specialities resulted from the Basque
autonomous legislation and finally the important role that Local organic rules may
have in that task.
Юрак туғма нуқсонлари билан янги туғилгандан 3 ёшгача булган болаларда антропометрик ўзгаришларни аниқлаш
Authors: Саидова Садоқат 
Published: March 2021

Ушбу мақолада янги туғилгандан 3 ёшгача бўлган болаларда жисмоний ривожланиш ва юракнинг эхокардиографик(ЭХОКГ) ўзгаришларни қиёсий хусусиятлари келтирилган. Тадқиқот натижалари янги туғилган чақалоқлар ва 3 ёшгача булган туғма юрак нуқсони билан туғилган болалар жисмоний ривожланиш кўрсатгичлари ( бўйи, вазни , кўкрак қафаси айланаси, қорин айланаси ) ўлчовлари ва ЭХОКГ кўрсатгичлари бўйича сезиларли даражада орқада қолиши аниқланди.
AFRICANIDADE NAS ESCOLAS PÚBLICAS DO MUNICÍPIO DE MANAUS: AVANÇOS E DESAFIOS PARA O DESENVOLVIMENTO DE UMA EDUCAÇÃO INTEGRAL ANTIRRACISTA
Authors: Monteiro Neves Soraya 
Published: March 2021

Resumo: A Lei 10.639/03 depositou diante do universo docente o desafio de propalar o Ensino de História e Cultura Afro-brasileira e Africana, numa perspectiva contrária a visão eurocêntrica predominante até então. Cabia às Secretarias de Educação subsidiar as escolas, o que exigia formação de equipes aptas ao processo, bem como compreensão da lei e mudanças nas concepções de currículo e práxis dos/as educadores/as. O presente artigo vem apresentar justamente a caminhada da Secretaria Municipal de Educação no Município de Manaus/SEMED/MANAUS quanto a inserção dos temas nas documentações. Apresenta a construção de uma Proposta Pedagógica Curricular/PPC, alinhada a lei. Contudo, traz a reflexão de que a mudança realizada na PPC é um avanço, mas não é garantia de disseminação de atitudes e conhecimentos necessários para a formação integral antirracista dos estudantes. A SEMED/MANAUS, reconhece que é necessário a mudança de postura dos educadores, por isso desde a implantação da referida PPC, realiza oficinas, formações e demais ações pertinentes a temática. Dessa forma conjectura-se que o trabalho dos/as professores tem caminhado na perspectiva da formação integral antirracista dos estudantes.
Palavras chaves: Lei 10.639/03. Escola. Currículo. Educação integral antirracista.
Turismo y Discapacidad. ¿Un marco regulatorio con inclusión?
Authors: Mazza María Claudia 
Published: March 2021

Este trabajo integra proyectos de investigación en temas de vacancia (convocatoria de PITVA 2017) y en proyectos del Departamento de investigación de la Universidad Nacional de Quilmes (período 2017-2019). Su propósito es contribuir a la reflexión sobre el marco jurídico-institucional vigente en materia turística, entendido como un instrumento comprendido por leyes y reglamentaciones en su relación con la jurisprudencia-costumbres-doctrina. Y como el sustento a las políticas públicas, sobre la necesidad de una plena inclusión social de las personas con discapacidad, consecuente de los principios de igualdad de oportunidad y no discriminación. Sobre esta relación, se ha tomado como elementos analíticos: las leyes nacionales y los tratados internacionales como un aporte esencial para el desarrollo de políticas públicas y proyectos que estimulan el desarrollo a partir del paradigma de la sustentabilidad
MicroRNA miR-212-3p targets NFIA to suppress HBV replication and tumor progression in hepatocellular carcinoma via repressing Enhancer I activity
Authors: Tian Hui , He Zhenkun 
Published: March 2021

IntroductionEmerging evidence identifies that microRNAs (miRNAs) are associated with hepatitis B virus (HBV) infection. In the current study, we mainly focus on the functions and underlying mechanisms of miR-212-3p in HBV replication in hepatocellular carcinoma (HCC).Material and methodsThe levels of miR-212-3p, nuclear factor I A (NFIA) and HBV DNA copies were measured by qRT-PCR. The level of core particle-associated HBV DNA, the productions of hepatitis B surface antigen (HBsAg) and hepatitis B e-antigen (HBeAg), and the expression of NFIA were detected via southern blot assay, ELISA and western blot assay, respectively. The putative target of miR-212-3p was predicted by TargetScan and Pictar, followed by the dual luciferase reporter assay and RNA immunoprecipitation (RIP) assay to validate the interaction. The interaction between miR-212-3p and Enhancer I/X promoter (EnI/Xp) reporter was also verified by dual luciferase reporter assay. In addition, the cell viability and apoptotic rate were detected by MTT and flow cytometry, respectively.ResultsmiR-212-3p mimics or NFIA knockdown inhibited HBV expression and replication in HepG2.2.15 cells, while miR-212-3p inhibitor or NFIA overexpression showed the opposite trend. NFIA was confirmed as a direct target of miR-212-3p. Furthermore, miR-212-3p impeded HBV expression and replication by suppressing NFIA. Besides, miR-212-3p lowered EnI/Xp activity by regulating NFIA. In addition, miR-212-3p retarded cell viability and induced apoptosis through targeting NFIA.ConclusionsmiR-212-3p targets NFIA to down-regulate its expression, thereby inhibiting HBV replication and tumorigenesis in HCC. Our finding might provide a promising therapeutic target for HBV infection.
CDX2 methylation may predict the prognosis of patients with lung cancer
Authors: Cui Hongxue , Zhang Zhenliang , Sun Xueli , Fu Ling , Zhao Xiaohua , Zhang Mingyue , Wang Meiying 
Published: March 2021

IntroductionCDX2 methylation predicts poor prognosis in gastric cancer, squamous esophageal cancer and colorectal cancer. The present study was performed to investigate the roles of CDX2 methylation in lung cancer.Material and methodsOne hundred and sixty-seven patients with lung cancer were enrolled. Methylation-specific PCR (MSP) was performed to investigate the methylation status of CDX2. Sequencing of the CDX2 5’ CpG island was conducted as well. A 5-year follow-up was performed by a research nurse or dedicated physician. The primary endpoint was death related with lung cancer. Kaplan-Meier curve was used to analyze the survival situation of patients. Univariate and multivariate Cox analysis was performed to investigate the potential predictors for prognosis of patients with lung cancer.ResultsThe patients were classified into two groups according to CDX2 status: methylation (n=75) and unmethylation (n=92). After the 5-year follow-up, we found that the survival rate of patients with methylation of CDX2 was much lower than those with unmethylation of CDX2 (56% vs. 84.8%, P=0.000). Among the smoking patients, methylation of CDX2 was related with poorer prognosis of patients with lung cancer (P=0.000). DFS of patients with CDX2 methylation was lower than those without CDX2 methylation (56.0% vs. 73.9%, P=0.009). Univariate and multivariate Cox analysis demonstrated that CDX2 methylation served as independent prognostic predictor of patients with lung cancer (univariate: HR=3.705, 95%CI=1.922-7.139; multivariate: HR=3.418, 95%CI=1.826-6.397).ConclusionsCDX2 methylation may serve as independent prognostic predictor for patients with lung cancer.
Pyrolysis of ripe and thin aspen Wood
Authors: Евдокимова Е.В. , Гиндулин И.К. , Юрьев Ю.Л. 
Published: March 2021

Изучен процесс пиролиза спелой и тонкомерной осиновой древесины в диапазоне конечной темпе- ратуры пиролиза 400–700 °С. Определены зависимости выхода древесного угля (ДУ) от температуры продолжительности пиролиза. Получены уравнения регрессии для основных показателей качества ДУ из осины, таких как содержание нелетучего углерода, суммарный объем пор, кажущаяся плотность и активность по йоду. Показано, что ДУ, полученный из спелой осиновой древесины при температуре не менее 600 °С, имеет сформированную углеродную матрицу и вполне пригоден для получения актив- ных углей.
The process of ripe and thin aspen wood pyrolysis in the range of the final pyrolysis temperature of 400–700 °С is studied. The dependences of the charcoal yield on the temperature and duration of pyrolysis are determined.
Regression equations for the main indicators of the aspen charcoal quality, such as content of non-volatile carbon, total pore volume, apparent density, and iodine activity are obtained. It is shown that the charcoal obtained from ripe aspen wood at a temperature of at least 600 °С has a formed carbon matrix and is quite suitable for the produc- tion of active carbons.
Analisis yang Mempengaruhi Niat Bertransaksi Online di E-Commerce Shopee di Kota Denpasar Provinsi Bali
Authors: Widiana I Nyoman Wahyu 
Published: March 2021

Perubahan pola perilaku dan kebutuhan konsumen mengikuti perkembangan teknologi dan arus informasi menjadikan lebih bertingkah laku praktis. Konsumen membutuhkan kecepatan dan ketepatan dalam pemenuhan kebutuhan. E-commerce adalah jawaban atas kecepatan dan ketepatan pemenuhan kebutuhan konsumen yang menawarkan keunggulan kompetitifnya yakni lebih hemat waktu, dan praktis.Tujuan penelitian ini untuk menganalisis pengaruh keamanan, kepercayaan, dan privasi terhadap niat bertransaksi secara online di e-commerce Shopee secara simultan dan parsial. Penelitian ini menggunakan metode kuantitatif dengan pendekatan survei. Penarikan sampel penelitian menggunakan accidental sampling, dengan sampel penelitian sebanyak 110 responden yang merupakan konsumen pengguna E-commerce Shopee di Kota Denpasar Provinsi Bali. Hasil penelitian diolah dengan menggunakan SPSS kemudian dianalisis dengan menggunakan analisis regresi linear berganda. Hasil analisis regresi linier berganda uji F (simultan), disimpulkan bahwa variabel keamanan, kepercayaan, dan privasi memiliki pengaruh terhadap variabel niat bertransaksi online di e-commerce Shopee di Kota Denpasar Provinsi Bali, hasil analisis uji t disimpulkan bahwa variabel keamanan, kepercayaan, dan privasi berpengaruh signifikan secara parsial terhadap variabel niat bertransaksi secara online di e-commerce Shopee di Kota Denpasar Provinsi Bali. Artinya, semakin tinggi tingkat keamanan, kepercayaan, privasi yang dilakukan oleh e-commerce Shopee maka semakin tinggi niat bertransaksi online di e-commerce Shopee, dan sebaliknya semakin rendah tingkat keamanan, kepercayaan, privasi yang dilakukan oleh e-commerce Shopee maka semakin rendah pula niat bertransaksi online di e-commerce Shopee. Oleh karena itu untuk meningkatkan niat bertransaksi online di e-commerce Shopee, maka pihak perusahaan memperhatikan faktor-faktor keamanan, kepercayaan, dan privasi dalam menerapkan dan mengembangkan transaksi e-commerce.
Faktor-faktor yang Mempengaruhi Voluntary Auditor switching (Studi Empiris pada perusahaan Non Financing yang Terdaftar di Bursa Efek Indonesia )
Authors: Siahaan Audrey , Saragi Dame Ria R. 
Published: March 2021

Fenomena auditor switching telah ditemukan bahwa memiliki implikasi terhadap kredibilitas nilai sebuah laporan keuangan dan biaya monitoring dari aktivitas manajemen. Sampel dalam penelitian ini ialah perusahaan non financing yang merupakan yang emiten di BEI selama periode 2017-2018 Pergantian Manajemen, dan pertumbuhan perusahaan secara bersama-sama tidak berpengaruh terhadap voluntary auditor switching. Audit Delay tidak berpengaruh terhadap voluntary auditor switching. Pergantian Manajemen tidak berpengaruh terhadap voluntary auditor switching. Pertumbuhan Perusahaan tidak berpengaruh terhadap voluntary auditor switching.
La estética de Georg Simmel en el joven Ortega
Authors: Gutiérrez Gutiérrez Eduardo 
Published: March 2021

Este artículo consiste en un análisis de la influencia que el filósofo berlinés Georg Simmel ejerce en las etapas iniciales de la filosofía de José Ortega y Gasset. En este caso, nos centraremos en la influencia que la estética simmeliana ejerce sobre el joven Ortega para la configuración de una teoría de la evolución histórica de las artes en la que se revelan algunas de las tesis fuertes que caracterizarán su pensamiento maduro.
Cabe destacar que este artículo se incluye dentro de un proyecto de análisis de la relación de influencia entre Simmel y Ortega, una influencia que abarca múltiples campos del pensamiento filosófico y científico, como la epistemología, la estética, la ontología, la sociología, etc., así como diversos e interesantes contenidos de análisis.
El objetivo principal es demostrar que bajo las ideas fundamentales de la filosofía de la razón histórica y vital de Ortega y Gasset fluye la tensión entre la vida y la forma que es la base del pensamiento simmeliano.