bluuebunny/crossref_metadata_2025_split huggingface dataset:
A trial patch to the extracurricular perspective of sustainable development program in elementary schools of Turkey
Authors: ŞEKER Fatih , AYDINLI BAHATTIN 
Published: December 2021

Abstract
Sustainable development (SD) and science education have become interwoven categorical issues under the name of science education for sustainable development (SESD). Education can play a crucial role in merging the dimensions of SD as ecology, economy, and energy, along with society in a united holistic goal. Furthermore, it can provide the necessary motivation and self-fulfillment for individuals and communities. Extracurricular activities should also be implemented along with formal ones in courses that are related to socio-scientific issues like SD. In line with this perspective, this study mainly aims to find new means of developing an extracurricular module program based on the principles of SD, in order to address the defects, deficiencies, and needs in science education around the world. For the sake of these, the module program was constructed kneading concepts of energy transformations, biodiversity, and narrating socio-scientific problems that would foster positive student decision-making on SD issues. The study also aims to examine whether the SESD module program would have a significant effect on the academic success and opinions regarding SD of primary school students in science lessons. The study sample comprised 92 Turkish fifth-grade students. A mixed method was handled by allowing qualitative and quantitative research methods in the same context. Qualitative and quantitative data analysis revealed that the SESD module program significantly affected fifth-grade students in terms of their knowledge and opinions to increase their willingness to take action and responsibility.
Urbanization, Electromagnetic Radiation and Sparrows: A Case Study from Guwahati, India
Authors: Nath Anukul , Singha Hilloljyoti , Lahkar Bibhuti Prasad 
Published: December 2021

Abstract
The persisting growth of wireless telecommunication technology causes increased electrosmog. Exposure to wide-ranging radiofrequency electromagnetic fields is thought to be a concern for all the living species across the globe. Studies have shown possible effects of electromagnetic radiation on various organisms including electromagnetic radiation risk on birds, but the outcomes were inconsistent. Here, we investigated if there is any impact of electromagnetic radiation on the abundance and habitat use of sympatric House Sparrow and Tree Sparrow in Guwahati City, India. In addition, we did a comparative analysis of previous work that had been conducted on possible effects of EMR on wild birds in field condition. We collected sparrow abundance in selected urbanization gradients temporally over a period of two years in 45 locations and spatially covering 168 locations in the eastern part of Guwahati City. Point counts were carried out, and successively we measured the electromagnetic radiation along with other ecological covariates. It was observed that ecological variables contributed significant variation to explain the habitat use of sparrows in Guwahati City compared to electromagnetic radiation. We observed that House Sparrow had quadratic relationship and Tree sparrow had negative association with increasing urbanization. Studies carried out in the past on the impacts of electromagnetic radiation on birds outside the lab condition had not considered other ecological covariates, which could also influence the life history needs of the bird species. Our study emphasized that the ecological covariates should be taken into consideration while studying the effect of electromagnetic radiation on wild organisms.
New Extended Topsis Method Based On The Entropy Measure And Picture Fuzzy Rough Set Information And Their Application In Decision Support System
Authors: Khan Muhammad Ali , Abdullah Saleem , Qadir Abbas 
Published: December 2021

Abstract
In this article, we shall introduce a novel technique for order preference by similarity to ideal solution (TOPSIS)-based methodology to resolve multicriteria group decision-making problems within picture fuzzy environment, where the weights information of both the decision makers (DMs) and criteria are completely unknown. First, we briefly review the definition of picture fuzzy sets (PFS), score function and accuracy function of PFRSs and their basic operational laws. In addition, defined the generalized distance measure for PFRSs based on picture fuzzy rough entropy measure to compute the unknown weights information. Secondly, the picture fuzzy information based decision-making technique for multiple attribute group decision making (MAGDM) is established and all computing steps are simply depicted. In our presented model, it's more accuracy and effective for considering the conflicting attributes. Finally, an illustrative example with robot selection is provided to demonstrate the effectiveness of the proposed picture fuzzy decision support approaches, together with comparison results discussion, proving that its results are feasible and credible.
Silicon Embolization Syndrome - A Diagnostic and Therapeutic Dilemma: A Case Series and Review of the Literature
Authors: Mumtaz Aqsa , Farrukh Larabe , Dar Tawseef , Naveed Hamza , Siddique Saad , Saeed Subhan , Shahid Aneeqa , Javaid Risham , Khan Sehrish Sohail 
Published: December 2021

Abstract
In scientific literature, silicone embolization syndrome has been well described and multiple presentations have been delineated. The use of non-medical injections of silicone has become very popular with the public in general, in particular with certain groups that are highly focused on their physical image. Local effects including tissue necrosis, foreign body giant cell reaction, and community-acquired infection have been commonly recorded. Distal effects suggesting an embolic phenomenon can present as regional lymphadenopathy, granulomatous hepatitis, interstitial nephritis, and other acute systemic illnesses. But pulmonary and neurologic sequelae especially warrant emergency attention and can be fatal, if not identified immediately. Pulmonary manifestation can sometimes easily mimic bilateral pneumonia, especially if there is no suspicion for illicit silicone use, which was the case with our patients. The injected subcutaneous silicone migrated rapidly from the interstitial subcutaneous tissue into the general bloodstream resulting in systemic silicone embolization. An analysis of the presented case in conjunction with a review of the pertinent medical literature, including relevant case reports revealed the common clinicopathological manifestations of silicon embolism.
Eukaryotic Translation Initiation Factor 3 Subunit B Promotes Head And Neck Cancer Via CEBPB Translation
Authors: Xu Chengzhi , Shen Yupeng , Shi Yong , Zhang Ming , Zhou Liang 
Published: December 2021

Abstract
Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type worldwide. Deregulation of mRNA translation is a frequent feature of cancer. Eukaryotic Translation Initiation Factor 3 Subunit B (EIF3B) has reported as oncogenes in cancer. However, the role of EIF3B in HNSCC remains unclear. Methods: In this study, the clinical significance of EIF3B expression in TCGA was analyzed. Then the expression of EIF3B was knockdown, and its role in HNSC was revealed. To explore the molecular mechanism of EIF3B, we applied RNA sequencing and proteomics, and deregulated pathways were acquired. RNA immunoprecipitation (RIP) sequencing was conducted to uncover the targeting mRNAs of EIF3B. Potential targets of EIF3B were validated with TCGA datasets.Results: EIF3B serves a hazardous prognostic marker in HNSCC. Besides, EIF3B promotes HNSCC proliferation and progression in vitro and in vivo. EIF3B promotes CEBPB translation and activate MAPK pathway. IL6R and CCNG2 is a target of EIF3B regulated CEBPB translation. Conclusion: In sum, this study reveals EIF3B as a novel oncogene in HNSCC, by promoting CEBPB translation and IL6R expression.
Intracellular Drug Targets In Mycobacterium Tuberculosis Revealed By A Chemo-Genetic Approach
Authors: Tsui Clement K.M. , Sorrentino Flavia , Gagandeep Narula , Losanna Alfonso Mendoza , Rio Ruben Gonzalez , Herrán Esther Pérez , Lopez Abraham , Bojang Adama , Zheng Xingji , Remuinan-Blanco Modesto Jesus , Av-Gay Yossef 
Published: December 2021

Abstract
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is one of the most devastating infectious agents in the world. It causes chronic lung diseases to one third of the world’s population. Chemo-genetic characterization through in vitro evolution combined with whole genome sequencing analysis can identify novel drug targets and drug resistance genes in Mtb. We performed a genome analysis of 53 Mtb mutants resistant to 15 different hit compounds. We found nonsynonymous mutations/indels in 30 genes that may be associated with drug resistance acquisitions. Beyond confirming previously identified drug resistance mechanisms such as rpoB and lead targets reported in novel anti-tuberculosis drug screenings such as mmpL3, ethA, mbtA, we discovered several unrecognized candidate drug targets including prrB and TB18.5. The exploration of the M. tuberculosis chemical mutant genomes could help novel drug discovery and structural biology of compounds and asscoiated mechanisms of action relevant to tuberculosis treatment.
The effect of Sharia bank knowledge, promotion, and facilities on savings decisions at Sharia banks with savings interest as mediation variables
Authors: Utamy Oriesta Dhea Budi , Widhiastuti Ratieh 
Published: December 2021

Purpose - The purpose of this study is to explain the effect of Sharia bank knowledge, promotion, and facility on saving decisions in Shariah bank both directly and through saving interest.Method - The population in this study is the students of Sharia banking department at Islamic Business and Economics Faculty of IAIN Purwokerto Batch 2016/2017 of 106 students. All populations in this study were used as the sample. The technique of data collection in this study used questionnaires. Techniques of data analysis used descriptive statistic analysis and path analysis. Result - The results showed that Sharia bank knowledge, promotion, and facility give a positive and significant effect on saving decisions in Sharia Bank. Saving interest can mediate Sharia bank knowledge, promotion, and facility on saving decisions in Sharia Bank.Implication - Suggestion from this study are expected that Sharia Bank can fix the facility and improve promotions so that the customer candidate can know what kind of product offered so that saving interest and saving decision in Sharia Bank can be improved.Originality - This study adds Islamic bank knowledge and saving interest variable as the intervening variable.
Improving Digital Image Quality for Convolution Neural Network Based Computer-Aided Diagnosis (CNN-CAD) of Skin Cancer
Authors: YALÇIN Tolga , TANDİROVİC GÜRSEL Amira 
Published: December 2021

The practice of detecting skin cancer is based primarily on a visual examination by a dermatologist, followed by a series of tests for a more accurate diagnosis. The concept “the earlier cancer is detected in its natural history, the more effective the treatment is likely to be" is also valid for skin cancer. Hence, any delayed or missed diagnosis can lead to a more severe clinical stage or, what's worse, death. On the other hand, the lack of biomarkers in clinical use brings about overdiagnosis and unnecessary biopsies.
DL-CAD system seems to be an excellent candidate for improving diagnostic accuracy and reducing unnecessary treatments. However, the vast majority of conventional CADs manipulate dermoscopic images, which require not only costly equipment but also time-consuming processing. Despite the difficulties with precision, state-of-the-art DL-CAD systems provide an interpretation using digital images, requiring no expertise in cost-effective dermoscopic image capture and interpretation. Pre-processing methods play a crucial role in solving this problem. This study presents results with regard to pre-processing steps to improve the images to be used in the diagnosis of the 5 most common skin cancer types for the proposed CNN based ResNet50 deep learning model. To the best of our knowledge it is the first time that ResNet50 deep-learning model has been utilized in diagnosis of skin cancer.
GENÇ YETİŞKİNLERDE POSTÜRÜN SAĞLIKLA İLGİLİ YAŞAM KALİTESİ ÜZERİNE ETKİSİNİN ARAŞTIRILMASI
Authors: YAGCI Gözde , BEK Nilgün 
Published: December 2021

Amaç: Postür, fiziksel ve psikososyal iyilik hali ile ilişkilendirilmektedir. Postüral sapmalar çoğu zaman asemptomatik olduğu için göz ardı edilebilmekle beraber, uzun dönemde kas iskelet sistemi problemlerine yol açabilir. Bu retrospektif çalışmanın amacı, genç yetişkin bireylerde postürün sağlıkla ilgili yaşam kalitesi üzerine etkisini araştırmaktı.
Yöntem: Yaşları 18-34 yıl arasında değişen 90 sağlıklı birey, postür ve yaşam kalitesi açısından değerlendirildi. Postür, postüral dizilim açısından Reedco Postür Skoru (RPS) ve postüral simetri açısından posterior gövde simetri indeksi (POTSI) ile değerlendirildi. Bireylere yaşam kalitesini değerlendirmek için SF-36 Kısa Form uygulandı.
Sonuçlar: Sonuçlar, POTSI gövde simetri indeksi ile SF-36 Kısa Form Anketinin fiziksel fonksiyon (r=-0,317), mental sağlık (r=-0,425), zindelik (r=-0,296), ağrı (r=-0,358), genel sağlık algılaması (r=-0,284) puanları arasında negatif yönlü ve düşük-orta şiddette ilişki olduğunu gösterdi (p
RELATIONSHIP BETWEEN SITTING POSTURE, SITTING BALANCE AND UPPER EXTREMITY FUNCTIONS IN CHILDREN WITH SPINA BIFIDA
Authors: ATALAY Güler , ACAR Gönül 
Published: December 2021

Purpose: To evaluate the relationship between the sitting posture, sitting balance and upper extremity functions of children with Spina Bifida (SB).
Methods: Thirty-one children with SB, and aged 5-18 years, were included the study. Their physical and clinical characteristics were recorded. Seated Postural Control Measure (SPCM), Pedalo® Balance Measurement System, Sitting Assessment for Children with Neuromotor Dysfunction (SACND), Modified Functional Reach Test (MFRT) and Jebsen-Taylor Hand Function Test (JTHFT) were used.
Results: There was a significant correlation between JTHFT results and the other test results, i.e. Pedalo® (r = -0.478, p=0.007), SACND (r=0.399, p=0.026) and MFRT (r = -0.598, p
Interleukin-10 in the Vasculature: Pathophysiological Implications
Authors: de Freitas Raiany A. , Lima Victor V. , Bomfim Gisele F. , Giachini Fernanda R.C. 
Published: December 2021

Abstract:
Interleukin-10 (IL-10) is an important immunomodulatory cytokine, initially characterized
as an anti-inflammatory agent released by immune cells during infectious and inflammatory
processes. IL-10 exhibits biological functions that extend to the regulation of different intracellular
signaling pathways directly associated with vascular function. This cytokine plays a vital role in
vascular tone regulation by changing important proteins involved in vasoconstriction and vasodilation.
Numerous investigations covered here have shown that therapeutic strategies inducing IL-10
exert anti-inflammatory, anti-hypertrophic, anti-hyperplastic, anti-apoptotic and antihypertensive effects.
This non-systematic review summarizes the modulating effects mediated by IL-10 in vascular
tissue, particularly on vascular tone, and the intracellular pathway induced by this cytokine. We
also highlight the advances in IL-10 manipulation as a therapeutic target in different cardiovascular
pathophysiologies, including the physiological implications in animals and humans. Finally, the review
illustrates current and potential future perspectives of the potential use of IL-10 in clinical
trials based on the clinical evidence.
Treatment of Narcolepsy: A Rare Disease of Unknown Etiology
Authors: Campos Joaquín M. , Molina Claudia 
Published: December 2021

Background:
Narcolepsy, also known as Gélineau syndrome, is a chronic and neurological
disease that affects 0.05% of the European population, though that percentage could be higher due to the
diagnostic difficulties. The main symptom is excessive daytime sleepiness, although it may be accompanied
by cataplexy, sleep paralysis and hypnagogic hallucinations.

Objective:
Nowadays, there is no cure for narcolepsy, and the treatment is symptomatic; psychostimulants
for sleepiness by means of amphetamines, methylphenidate, or modafinil, and antidepressants and sodium
oxybate for treating cataplexy.

Method:
This is a short review regarding pharmacotherapy for narcolepsy.

Result:
Hypocretins were discovered in 1998. They are neuropeptides whose deficiency is responsible
for this symptomatology, which has opened up a new field of investigation.

Conclusion:
Agonists of hypocretins could be a promising therapy against this disease.
Assessment of the Efficiency of HP-Guar and hyaluronic Acid Tear Supplements to Control Tear Film Evaporation Rate in Dry Eye Subjects
Authors: Abusharha Ali , Shbear Abdulrhman A. , Fagehi Raied , Alanazi Mana A. , Alsaqr Ali , El-Hiti Gamal A. , Masmali Ali M. 
Published: December 2021

Background:
The most common factor that could lead to dryness is the accelerated tear evaporation rate. Controlling the tear evaporation rate is increasingly used as a method to control dry eye complications. The present study explores the effects of different tear supplements formulations on tear film evaporation rate.

Objective:
This study aimed to evaluate the short-term effects of Systane ULTRA and Artelac Advanced eye drops on the tear film evaporation rate.

Methods:
Fifteen male dry eye subjects were enrolled in the current study. Tear film parameters were observed at several time points post installation (10, 20, 30, and 60 min). The tear film parameters observed in the current study were tear evaporation rate, noninvasive breakup time (NITBUT) and tear meniscus height (TMH). Two visits were required to conduct this study. One visit was conducted to assess the physiological tear film parameters with the use of Systane® ULTRA eye drop. The other visit was conducted to assess tear film parameters with the use of Artelac Advanced eye drop.

Results:
The mean tear evaporation rate at baseline was 52.58 ± 23.24 g/m2 h. A box plot of tear evaporation showed a reduction in tear film evaporation rate after instillation of Systane eye drop. A drop in tear film evaporation rate of 14% was observed at 20 and 60 min time point after instillation of Systane ULTRA eye drop. A significant increase in NITBUT was found after instillation of Systane ULTRA (P = 0.01) and Artelac Advanced (P = 0.02).

Conclusion:
The current study indicates a significant improvement in the tear film parameters using both HP-Guar and hyaluronic acid formulations. However, it was apparent that the use of HP-Guar was superior to hyaluronic acid in controlling the tear evaporation rate in dry eye subjects.
Muscle Activation and Torso Movement during Exercise using Novel Fiberglass Resistance Poles
Authors: Glass Stephen 
Published: December 2021

Background:
A novel form of functional training utilizes flexible fiberglass poles for resistance. Similar to elastic bands, as the poles flex, resistance increases. To date, no studies have examined activation patterns associated with such implements.

Objective:
This study examined muscle activation and torso rotation using different pole resistance intensities during a “push-pull” rotational core exercise.

Methods:
Twenty-one subjects (16 women, 5 men; age=20.4±1.3y) completed 6 trials of 10 repetitions each of a standing push and pull movement with 3 different pole tensions (very light, light, moderate). Muscle activation (electromyography) for the anterior and posterior deltoid, abdominal oblique, and paraspinal muscles were recorded. Concentric contractions during the push phase (PUSH) and the pull load (PULL) phases were recoded, and percent maximal voluntary contraction (%MVC) was computed. Markers on the acromion process and a vertically mounted camera were used to record torso rotation during each push and pull. ANOVA for each muscle and PUSH and PULL was used for comparisons across pole intensity.

Results:
Significant main effects for torso rotation were seen, with rotation with the very light pole (Push= 61.9 ± 9.20, Pull= 64.8 ± 14.00) significantly greater than moderate (Push= 52.0 ± 12.80, Pull= 54.9 ± 10.10). EMG data were highly variable, with no differences in muscle activation detected across pole resistance loads.

Conclusion:
Variability of the EMG data prevent clear resolution of activation patterns. However, torso rotation is limited with heavier pole resistance since increased pole flex also increases resistance.
The Effectiveness of Physical Activity-Promoting Web- and Mobile-Based Distance Weight Loss Interventions on Body Composition in Rehabilitation Settings: Systematic Review, Meta-analysis, and Meta-Regression Analysis
Authors: Lahtio Heli , Rintala Aki , Immonen Jaakko , Sjögren Tuulikki 
Published: December 2021

Background
Overweight and obesity are major problems worldwide, and they lead to an increased risk for several diseases. The use of technology in the treatment of obesity is promising, but in the existing literature, there is considerable uncertainty regarding its efficacy. In this review, we included web- and mobile-based weight loss interventions that were implemented remotely in rehabilitation settings.

Objective
The aim of this systematic review is to study the effectiveness of physical activity-promoting web- and mobile-based distance weight loss interventions in rehabilitation settings on body composition in comparison with control groups that did not use technology.

Methods
Studies were searched from 9 databases. The inclusion criteria were as follows: population: age 18-65 years; intervention: physical activity-promoting web- and mobile-based distance weight loss interventions; comparison: control groups without the use of technology; outcome: changes in BMI, waist circumference, or body fat percentage; study design: randomized controlled trial. The quality of the studies was assessed by 2 researchers. Meta-analysis was performed, and we also conducted a meta-regression analysis to evaluate the factors associated with the changes in body composition outcomes if statistical heterogeneity was observed.

Results
The meta-analysis included 30 studies. The mean quality of the studies was 7 of 13 (SD 1.9; range 3-10). A statistically significant difference was observed in BMI (mean difference [MD] 0.83, 95% CI 0.51-1.15 kg/m2; P<.001), waist circumference (MD 2.45, 95% CI 1.83-3.07 cm; P<.001), and body fat percentage (MD 1.07%, 95% CI 0.74%-1.41%; P<.001) in favor of the weight loss groups using web- or mobile-based interventions. Meta-regression analyses found an association between personal feedback and BMI (P=.04), but other factors did not play a role in explaining statistical heterogeneity.

Conclusions
Web- and mobile-based distance weight loss interventions significantly reduced BMI, waist circumference, and body fat percentage. Future studies should focus on the comparability of the intervention content. Future studies are needed to better understand weight loss and identify which components are essential in achieving it.

Trial Registration
PROSPERO CRD42016035831; https://tinyurl.com/7c93tvd4