bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistical harmonization can improve the development of a multicenter CT‐based radiomic model predictive of nonresponse to induction chemotherapy in laryngeal cancers
Authors: Masson Ingrid , Da‐ano Ronrick , Lucia François , Doré Mélanie , Castelli Joel , Goislard de Monsabert Camille , Ramée Jean‐François , Sellami Selima , Visvikis Dimitris , Hatt Mathieu , Schick Ulrike 
Published: May 2021

PurposeTo develop a radiomic model predicting nonresponse to induction chemotherapy in laryngeal cancers, from multicenter pretherapeutic contrast‐enhanced computed tomography (CE‐CT) and evaluate the benefit of feature harmonization in such a context.MethodsPatients (n = 104) eligible for laryngeal preservation chemotherapy were included in five centers. Primary tumor was manually delineated on the CE‐CT images. The following radiomic features were extracted with an in‐house software (MIRAS v1.1, LaTIM UMR 1101): intensity, shape, and textural features derived from Gray‐Level Co‐occurrence Matrix (GLCM), Neighborhood Gray Tone Difference Matrix (NGTDM), Gray‐Level Run Length Matrix (GLRLM), and Gray‐Level Size Zone Matrix (GLSZM). Harmonization was performed using ComBat after unsupervised hierarchical clustering, used to determine labels automatically, given the high heterogeneity of imaging characteristics across and within centers. Patients with similar feature distributions were grouped with unsupervised clustering into an optimal number of clusters (2) determined with “silhouette scoring.” Statistical harmonization was then carried out with ComBat on these 2 identified clusters. The cohort was split into training/validation (n = 66) and testing (n = 32) sets. Area under the receiver operating characteristics curves (AUC) were used to evaluate the ability of radiomic features (before and after harmonization) to predict nonresponse to chemotherapy, and specificity (Sp) and sensitivity (Se) were used to quantify their performance in the testing set.ResultsWithout harmonization, none of the features identified as predictive in the training set remained significant in the testing set. After ComBat, one textural feature identified in the training set keeps a predictive trend in the testing set—Zone Percentage, derived from the GLSZM, was predictive of nonresponse in the training set (AUC = 0.62, Se = 70%, Sp = 64%, P = 0.04) and obtained a satisfactory performance in the testing set (Se = 80%, Sp = 67%, P = 0.03), although significance was limited by the size of the testing set. These results are consistent with previously published findings in head and neck cancers.ConclusionsRadiomic features from CE‐CT could help in the selection of patients for induction chemotherapy in laryngeal cancers, with relatively good sensitivity and specificity in predicting lack of response. Statistical harmonization with ComBat and unsupervised clustering seems to improve the predictive value of features extracted in such a heterogeneous multicenter setting.
Quality of life in patients with endometrial carcinoma: A Longitudinal Study
Authors: Chen Jiebing , Zou Qiaojian , Chen Xuanmin , Liu Xiaochen , Ding Sha , Mo Yinglei , Yao Shuzhong 
Published: May 2021

AbstractAimTo investigate the quality of life in patients with endometrial carcinoma and provide theoretical basis for nursing care.DesignIn this study, 69 patients diagnosed with endometrial carcinoma from 2016–2018 were included in the cohort.MethodsSixty‐nine patients from our hospital who underwent endometrial cancer surgeries were selected. The SF‐36 was used to investigate and analyse the patients’ quality of life in the first, second and third months after their operations. Questionnaires were administered to analyse the factors affecting postoperative quality of life.ResultsQuality of life for the second and third months was obviously better than that for the first month after the operation (p < .05). Based on multivariate regression analysis, we found that patients with higher family income had better quality of life after surgery(p < .05). These results can provide some guidance for daily nursing work after endometrial cancer operation.
Aging of bolted joints prepared from electron‐beam‐cured multiwalled carbon nanotube‐based nanocomposites with variable torques
Authors: Kumar Mohit , Saini Jaswinder Singh , Bhunia Haripada , Chowdhury Subhendu Ray 
Published: May 2021

AbstractWe evaluate the behavior of a bolted joint prepared from electron beam (EB)‐cured carbon/epoxy nanocomposites under accelerated weathering environment at varying bolt tightening torques. For strength improvement, different weight percentages (wt%) of multiwalled carbon nanotubes (MWCNTs) in the range 0.1–0.5 wt% were incorporated into the composite laminates; 0.3 wt% of MWCNT had the maximum tensile strength. The properties of EB‐cured composites were compared with those of thermally cured ones. For accelerated weathering, cyclic exposure of ultraviolet (UV) radiation as well as condensation at elevated temperatures was conducted for 1000 h on the nanocomposite specimens. The chemical, physical, thermal, and mechanical properties of the nanocomposites were studied under accelerated aging conditions. To determine the failure loads in the bolted joints, specimens were prepared as per ASTM D5961. It was found that after 1000 h of aging, there was only 5% reduction in the ultimate failure load for joints prepared with the addition of MWCNTs. It was also found that the bolt torque had a positive effect on the performance of the joints. The experimental results were validated with progressive damage analysis using the characteristic curve method along with the Hashin damage criteria.
Mass spectrometry‐based proteomic analysis of the effect of storage temperature on non‐invasively collected samples of human stratum corneum
Authors: Azimi Ali , Teh Rachel , Fernandez‐Penas Pablo 
Published: May 2021

AbstractPurposeThe collection of human stratum corneum (SC) samples by tape‐stripping promises to deliver a non‐invasive method for biomarker analysis of skin diseases. The current study examines the effect of storage temperature and SC layer depth on the proteome profile of SC samples.Experimental DesignThe samples were collected from healthy volunteers (n = 5) using 10 sequential adhesive discs. Discs were pooled by five (discs 1–5, 6–10) and stored at various temperatures for 10 days before their analysis by mass spectrometry.ResultsNo statistically significant difference was seen in the protein yield between discs 1–5 (14.8 mg) and 6–10 (14.4 mg), or between discs stored at ‐80°C (14.7 mg), ‐20°C (15.8 mg), 4°C (14.9 mg) or room temperature (13.2 mg). Mass spectrometry analysis revealed that the storage of SC samples at higher temperatures does not affect their proteome profile considerably (< 4.7% peptide precursor loss at lower temperatures vs. ‐80°C). On the other hand, while 95.3% of the identified peptide precursors were shared between discs 1–5 and 6–10, the level of 17 proteins was significantly changed between these conditions.ConclusionsThe findings of this study will likely have major implications on the conduct of proteomic studies involving SC sample collection, storage, and transportation.
Florylpicoxamid, a new picolinamide fungicide with broad spectrum activity
Authors: Yao Chenglin , Meyer Kevin G , Gallup Courtney , Bowling Andrew J , Hufnagl Andrea , Myung Kyung , Lutz Jamie , Slanec Thomas , Pence Heather E , Delgado Javier , Wang Nick X 
Published: May 2021

AbstractBACKGROUNDFollowing the introduction of fenpicoxamid, a natural product‐based fungicide targeting the Qi site of mitochondrial cytochrome bc1 complex, a second generation fully synthetic picolinamide, florylpicoxamid, was discovered and its biological activity and attributes were characterized.RESULTSIn vitro fungal growth inhibition assays and in planta glasshouse biological activity evaluations showed florylpicoxamid was active against 21 different plant pathogenic fungi within the phyla Ascomycota and Basidiomycota. Among the pathogens evaluated, florylpicoxamid was most potent against Zymoseptoria tritici, the causal organism of wheat leaf blotch, providing 80% growth inhibition in vitro at 0.0046 mg L−1 and 80% disease control in planta at 0.03 mg L−1 when applied as a preventative treatment. Florylpicoxamid was more efficacious than epoxiconazole, fluxapyroxad, and benzovindiflupyr versus a Z. tritici wild‐type isolate when applied as curative and preventative treatments, with superior 10‐day curative reachback activity. Analytical studies and in planta tests demonstrated that florylpicoxamid partitioned into plants quickly and showed good systemicity and translaminar activity on both monocot and dicot plants. No cross‐resistance was observed between florylpicoxamid and strobilurin or azole fungicides. Florylpicoxamid exerts its preventative effect by preventing spore germination on the leaf surface and curative activity by arresting mycelial growth and pycnidia development in leaf tissue.CONCLUSIONSWith strong broad spectrum fungicidal activity, florylpicoxamid delivers an innovative solution for growers to sustain high productivity and quality of many crops, and also provides a new option for developing effective strategies for fungicide resistance management. © 2021 Society of Chemical Industry.
Honeycomb‐like structures in sarcoidosis pathologically showing granulomas in walls of clustered bronchioles
Authors: Sawahata Michiru , Takemura Tamiko , Kawanobe Takeshi , Hagiwara Koichi , Kono Chiyoko , Yamaguchi Tetsuo 
Published: May 2021

AbstractIn the clinical setting, it is often difficult to judge whether honeycomb‐like structures represent progression of fibrosis in pulmonary sarcoidosis or a complication by interstitial pneumonitis. This report described a valuable case in which pathology of video‐assisted thoracoscopic surgery specimens collected from the lungs with honeycomb‐like structures that were continuous with the dilated bronchioles on chest computed tomography (CT) showed granulomas in the membranous bronchiole walls, thereby demonstrating that the honeycomb‐like structures were lung lesions of sarcoidosis. Pathological features of these structures on chest CT included cystic changes attributable to incorporation of peripheral alveoli into dilated bronchioles in lobules: these findings in lung sarcoidosis were different from those corresponding to honeycomb lung in idiopathic pulmonary fibrosis/usual interstitial pneumonia. Radiological and pathological findings showed the possibility that progressive clustering of dilated bronchi and bronchioles causes cystic changes, resulting in the formation of honeycomb‐like structures as fibrosis progresses in sarcoidosis with lung involvement.
Fire response of steel connections using gene expression programming and finite element method
Authors: Ketabdari Hesamoddin , Saedi Daryan Amir , Hassani Nemat , Safi Mohammad 
Published: May 2021

AbstractIn this paper, the behavior of bolted and welded beam‐to‐column connections exposed to high temperatures is investigated. In this regard, 16 effective parameters are considered as the inputs, along with the connection rotation as the output. Finite element models of bolted and welded connections have been verified and used to generate sufficient data for equation training by the gene expression programming (GEP) method. The results indicated that the relative error of the bolted and welded models is equal to 11% and 12.5%, andR2coefficients were 0.9 and 0.85, respectively. Comparing the results acquired from the GEP model and experimental tests approves a proper performance with an acceptable rate of error of the developed equations for both bolted and welded connections in fire conditions. This performance has adequate reliability, particularly in critical temperatures, where the connection failure occurs. Moreover, the development of formulas with such a degree of accuracy indicates the utmost importance of employing applicable algorithms in simulating complex interaction of structure and fire.
The Road to Structurally Defined β‐Glucans
Authors: Ross Patrick , Farrell Mark P. 
Published: May 2021

Abstractβ‐glucans are polymers of glucose that have been isolated from a variety of organisms. Isolated β‐glucans have been used for medical purposes for centuries; however, efforts to define the biological activities of β‐glucans experimentally were initiated in the 1940’s. The diversity of structure associated with isolated β‐glucans has impeded said investigations, and efforts to leverage the biological activity of β‐glucans for clinical applications. In recognition of the need for defined β‐glucans that retain the biological activity of isolated β‐glucans, considerable investment has been made to facilitate the synthesis of structurally defined β‐glucans. Here, we review the different approaches that have been applied to prepare β‐glucans. In addition, we summarize the approaches that have been utilized to conjugate β‐glucans to proteins.
Sharing Power in Read‐Alouds with Emergent Bilingual Students
Authors: Christ Tanya , Cho Hyonsuk 
Published: May 2021

AbstractThis article addresses a growing call for the use of more culturally relevant texts and pedagogy in classrooms. We present how a teacher sharing power with emergent bilingual (EB) students during read‐aloud discussions with culturally relevant texts supports EB students’ literacy opportunities. These opportunities include (1) initiating new topics in the discussions, (2) providing cognitive or linguistic supports for one another, (3) using multilingual abilities to identify vocabulary, and (4) using cultural knowledge to make spontaneous inferences. For each of these four opportunities, we discuss (a) how power is shared by the teacher with her EB students, (b) how sharing power opens learning opportunities for others, (c) how the culturally relevant text supports the learning opportunities, and (d) how students are positioned in the discussion. Finally, we present how teachers can share power, and choose culturally relevant texts that will facilitate these learning opportunities, in their own classrooms.
Celestial double copy from the worldsheet
Authors: Casali Eduardo , Sharma Atul 
Published: May 2021

AbstractUsing the ambitwistor string, we compute tree-level celestial amplitudes for biadjoint scalars, Yang-Mills and gravity to all multiplicities. They are presented in compact CHY-like formulas with operator-valued scattering equations and numerators acting on a generalized hypergeometric function. With these we extend the celestial double copy to tree-level amplitudes with arbitrary number of external states. We also show how color-kinematics duality is implemented in celestial amplitudes and its interpretation in terms of a generalized twisted cohomology theory.
Some remarks on the stability of the Cauchy equation and completeness
Authors: Fripertinger Harald , Schwaiger Jens 
Published: May 2021

AbstractIt was proved in Forti and Schwaiger (C R Math Acad Sci Soc R Can 11(6):215–220, 1989), Schwaiger (Aequ Math 35:120–121, 1988) and with different methods in Schwaiger (Developments in functional equations and related topics. Selected papers based on the presentations at the 16th international conference on functional equations and inequalities, ICFEI, Bȩdlewo, Poland, May 17–23, 2015, Springer, Cham, pp 275–295, 2017) that under the assumption that every function defined on suitable abelian semigroups with values in a normed space such that the norm of its Cauchy difference is bounded by a constant (function) is close to some additive function, i.e., the norm of the difference between the given function and that additive function is also bounded by a constant, the normed space must necessarily be complete. By Schwaiger (Ann Math Sil 34:151–163, 2020) this is also true in the non-archimedean case. Here we discuss the situation when the bound is a suitable non-constant function.
Predictive value of NLR, TILs (CD4+/CD8+) and PD-L1 expression for prognosis and response to preoperative chemotherapy in gastric cancer
Authors: Zurlo Ina Valeria , Schino Mattia , Strippoli Antonia , Calegari Maria Alessandra , Cocomazzi Alessandra , Cassano Alessandra , Pozzo Carmelo , Di Salvatore Mariantonietta , Ricci Riccardo , Barone Carlo , Bria Emilio , Tortora Giampaolo , Larocca Luigi Maria , Basso Michele , Martini Maurizio 
Published: May 2021

AbstractThe combination of perioperative chemotherapy plus complete surgical resection is currently accounted as the first-choice strategy in patients with locally advanced Gastric Cancer (LAGC). Nevertheless, the partial response rate makes it necessary to search biological parameters useful to select patients who would benefit most from neoadjuvant chemotherapy (NAD-CT). We performed a retrospective analysis on a cohort of 65 LAGC cases, EBV negative and without MMR defect, submitted to perioperative chemotherapy plus surgical resection. We evaluated the neutrophil-lymphocytes ratio (NLR) in peripheral blood, the TILs density (reported as CD4/CD8 tissue ratio) and PD-L1 expression by immunohistochemistry on bioptic tissues before the treatment. Results were correlated with the biological features, histological response (TRG) and clinical outcome (PFS and OS). We found that NLR, TILs and PD-L1 expression showed a significant correlation with TNM stage, lymphovascular invasion and response to NAD-CT (TRG). Correlating the NLR, TILs and PD-L1 expression with PFS and OS, we found that patients with lower NLR levels (< 2.5 ratio), lower TILs (< 0.2 ratio) and higher PD-L1 level (CPS ≥ 1) had a significantly better PFS and OS than those with higher NLR, higher TILs and lower PD-L1 expression (p < 0.0001). Multivariate and multiple regression analyses confirmed the predictive and prognostic role of all three parameters, especially when all three parameters are combined. Our study demonstrated that pre-treatment NLR, TILs and PD-L1 expression are predictive and prognostic parameters in NAD-CT-treated LAGC suggesting a pivotal role of the systemic and tumor microenvironment immunological profile in the response to chemotherapy.
Gender trends in authorships and publication impact in Academic Radiology—a 10-year perspective
Authors: Molwitz Isabel , Yamamura Jin , Ozga Ann-Kathrin , Wedekind Ilka , Nguyen Thai-An , Wolf Liesa , Kamo Minobu , Zhao Jing , Can Elif , Keller Sarah 
Published: May 2021

Abstract
Objectives
To analyze the development of publication numbers of female authors in high-, medium-, and low-impact radiological journals.

Methods
In this bibliometric analysis, gender of the first (FA) and senior author (SA) was assigned to all original research articles and reviews, published in 10 high-, medium-, and low-impact radiological journals in 2007/8 and 2017/18. The adjusted event rate (AER) and adjusted odds ratio (AOR) were calculated using mixed logistic and multinomial logistic regression models to assess and compare female publications according to impact factor, journal, author position, and combination.

Results
The proportion of female FA and female SA in N = 6979 (2007/2008) and N = 7383 (2017/2018) articles increased to 29.1% and 16.1% in 2017/2018, respectively. While most female authorships were continuously observed in medium-impact journals, the strongest increase occurred for both female FA (AOR 2.0; p < .0001) and SA (AOR 2.1; p < .0001) in low-impact journals. Female SA published significantly more often in a low- (AOR 1.5) or medium- (AOR 1.8) than in a high-ranking journal. Among the high-ranking journals, female FA published most frequently in European Radiology (32.4%; 95% CI [29.3–35.8]; p < .0001), female SA in Investigative Radiology (15.9%; 95% CI [13.7–18.4]; p < .0001). Male same-sex authorships decreased (AOR 0.9), but remained at least twice as common as all-female or mixed authorships.

Conclusion
The increase in female authorship is reflected in all impact areas. Female FA and SA increased most in low-ranking journals but are most common in medium-ranking journals. Female SA remain rare, especially in high impact journals.

Key Points
• Compared to the proportion of female radiologists worldwide, female senior authors are underrepresented in all impact areas, in particular in high-impact journals.
• Among the included high-ranking radiological journals, female first authors and senior authors were strongest represented in European Radiology and Investigative Radiology, while across all impact areas they mostly published in medium-ranking journals.
• Female author combinations were more frequent in low- and medium- than in high-ranking journals, whereas male author combinations remained more common than female senior author collaborations in all impact areas.
Reynolds stress tensor measurements using magnetic resonance velocimetry: expansion of the dynamic measurement range and analysis of systematic measurement errors
Authors: Schmidt Simon , John Kristine , Kim Seung Jun , Flassbeck Sebastian , Schmitter Sebastian , Bruschewski Martin 
Published: May 2021

AbstractThis study presents magnetic resonance velocimetry (MRV) Reynolds Stress measurements in a periodic hill channel with a hill Reynolds number of Re = 29,500. The velocity encoding scheme is based on the ICOSA6 method with six icosahedral encoding directions and multiple encoding values are measured to increase the dynamic range. The full Reynolds stress tensor is obtained from a voxel-wise three-dimensional Gaussian fit using the magnitude data of all acquisitions. The MRV results are compared to a wall-resolved large eddy simulation and laser Doppler velocimetry measurements conducted in the same channel. It is shown that the MRV Reynolds stress data have excellent precision and agree qualitatively with the reference data. However, there are apparent systematic deviations. One of the most prominent error contributions is the signal attenuation caused by higher orders of motion, which leads to an overestimation of the turbulence level. Another fundamental error is identified in the assumption that the turbulence is Gaussian distributed. With the presented reconstruction technique, the MRV data are fitted to a statistical model, and depending on the examined flow setup, the Gaussian model can lead to considerable errors. Possible ways of how to reduce all identified errors are presented. In summary, this technique enables Reynolds stress tensor measurements in complex internal flows with high dynamic range and excellent precision. However, several issues need to be resolved to make the turbulence quantification more accurate.Graphic abstract