bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors of Persistently Active Disease among Filipino Children with Systemic Juvenile Idiopathic Arthritis: a 10-Year Study in a Tertiary Hospital
Authors: Alberca Ivy Joy E , Collante MA. Theresa M , Bernal Christine B 
Published: September 2021

Background: Systemic juvenile idiopathic arthritis (SJIA) is one of the most common subtypes of arthritis among children in southeast Asia with higher progression of disease activity. Unsuccessful control of the disease may lead to long-term disability resulting in functional limitations that would affect productivity of the individual. Objective: The study determined the risk factors for persistently active disease among Filipino children aged 2 weeks to 18 years diagnosed with SJIA seen in the Section of Pediatric Rheumatology of the University of Santo Tomas Hospital (USTH) from June 2009 to June 2019. Methodology: A retrospective cohort study was done involving chart review of both clinical division and private division patients. The following parameters were determined: sex, age at diagnosis, time elapsed from symptom onset to diagnosis, joint involvement, inflammatory markers and extra-articular manifestation. Statistical analysis included frequencies, percentages and logistic regression for the risk factors of interest. Results: One hundred twenty-seven patients with SJIA who were appropriately treated for at least three years were included. Among which, 88 (69%) developed persistently active disease. Among them, 36 (41%) were diagnosed at 1-5 years old. Many were diagnosed (n=54, 61%) after five weeks. The most commonly affected joints were the wrists, knees and ankles. The most common contracture noted involved the cervical joint. Only 33 (26%) patients received biologic agents. Risk factors identified for the development of persistent disease activity were low hemoglobin levels at the time of diagnosis and after one month of treatment, elevated platelet count after a month, substantial joint count after three months and increased ESR after 6 months. Conclusion: The change or improvement of the joint count and in hemoglobin, platelet count and ESR levels after appropriate treatment may determine the risk for persistently active disease in Filipino children with SJIA.
USULAN PERBAIKAN KUALITAS PRODUK TOPSIDE MENGGUNAKAN METODE FMEA DI PT. XYZ
Authors: Berlyan Rahmawati , Kurniawan Wawan , Sari Indah Permata 
Published: September 2021

XYZ is a company engaged in fabrication. Quality is very important for the company because it can affect customer satisfaction. In the production process there are still defect problems found on the top side of the structural construction and it affects the quality of the part. The failure rate on the topside product has a 5:28% percentage exceeds the standards set by the company which is 2%. Based on the percentage of defects that have been obtained, the problem can be solved by fishbone analysis and FMEA. In the first stage using CTQ which aims to identify failures that occur and determine quality characteristics. The next step after identifying the failure that occurred can be calculated DPMO and Sigma Level. After getting the DPMO value and the Sigma level, identification of the root causes of the failure occurred. The causes of problems that have been analyzed using fishbone analysis can be solved using FMEA.
Keywords : DPMO, Tingkat Sigma, Fishbone analysis, FMEA
PENGARUH KONFLIK PERAN GANDA DAN STRES KERJA TERHADAP KINERJA MOMPRENEUR (WIRAUSAHA WANITA) DI KECAMATAN CIBUNGBULANG
Authors: Nurfadillah Dini , Mulyanti Rita Yuni , Nurtiah Nurtiah 
Published: September 2021

The purpose of this study was to analyze several variables that could influence the performance of mompreneurs (women entrepreneurs) in Cibungbulang District. As for the variables in this study are multiple role conflicts, job stress and performance. This research was conducted using primary data obtained from questionnaires filled out by 83 respondents in Cibungbulang District. The analytical method used is multiple linear regression analysis.
The results of this study indicate that multiple role conflicts have a negative and significant effect on performance, while job stress has a negative and insignificant effect on performance. The conclusion in this study is that multiple roles conflict and work stress simultaneously have a significant effect on the performance of mompreneurs (women entrepreneurs) in Cibungbulang District. The implications of this research for mompreneurs (women entrepreneurs) can pay attention to role conflicts regarding the division of time between business and family activities, so that they do not interfere with these two activities so that balance can be achieved, what can be done is to make a work schedule for business activities and homework. stairs.
Key words: multiple role conflict, job stress, performance.
Risk-adapted combined therapy with arsenic trioxide and all-trans-retinoic acid for de novo acute promyelocytic leuкaemia
Authors: Troitskaya V. V. , Parovichnikova E. N. , Semenova A. A. , Fidarova Z. T. , Sokolov A. N. , Galstyan G. M. , Spirin M. V. , Gribanova E. O. , Sysoeva E. P. , Dvirnyk V. N. , Naumova I. N. , Obukhova T. N. , Glinshchikova O. A. , Klyasova G. A. , Chabaeva Yu. A. , Kulikov S. M. , Savchenko V. G. 
Published: September 2021

Introduction. Non-chemotherapy for acute promyelocytic leukaemia (APL) with a combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) provides for a high patient survival rate at lesser toxicity as effectively or superior to standard chemotherapy programmes.Aim — assessment of the ATO–ATRA risk-adapted exposure protocol in management of de novo acute promyelocytic leucaemia.Materials and methods. A prospective study included 51 primary APL patients aged 18–76 years. The program included remission induction (ATO 0.15 mg/kg intravenously, ATRA 45 mg/m2 orally) for 30–60 days in a low-risk (until remission) and 60 days — in a high-risk cohort that had idarubicin therapy added on days 2 and 4. Remission consolidation was attained with four (low-risk) or five (high-risk) courses. Minimal residual disease was monitored with real-time PCR at all phases.Results. The high-risk cohort was assigned 15 (29.4 %), the low-risk cohort — 36 (70.6 %) patients. Therapy induction till APL morphological remission was performed in 48/51 (94 %) patients. Molecular APL remission was achieved in 47 (92 %) patients, 100 % in the low-risk and 80 % in high-risk cohort. Early mortality was 6 % (n = 3), death in remission — 2 % (n = 1). Differentiation syndrome (DS) occurred in 16 (31.7 %) patients, more frequently in the high-risk vs. low-risk cohort (53.3 % and 22.2 %, respectively, p = 0.05; odds ratio 4.0 [1.1–14.4]). DS developed on days 1–20 (3 days median) of therapy. DS risk factors: a high-risk status, haemorrhagic syndrome and infection at the disease onset. A median follow-up time in survivors was 12.9 months (2.5–34.3), a six-month overall survival — 92 % (95 % CI: 85–100 %). A six-month overall survival was 100 and 73 % in the low- and high-risk cohorts, respectively (95 % CI: 54–100 %, p = 0.001). APL relapse not registered, 47 (92 %) patients survived and achieved the first molecular remission.Conclusion. A differentiated risk-adapted approach to APL therapy with cytostatic treatment added in high-risk patients only provided for a 100 % molecular remission and relapse-free survival. Therapy failures (early mortality and death in remission) affected high-risk patients due to a severe individual condition at the time of APL diagnosis.
Minimal residual disease and b-cell subpopulation monitoring in acute b-lymphoblastic leukaemia patients treated on rall-2016 protocol
Authors: Galtseva I. V. , Davydova Y. O. , Parovichnikova E. N. , Gavrilina O. A. , Troitskaya V. V. , Kapranov N. M. , Nikiforova K. A. , Isinova G. A. , Zarubina K. I. , Sokolov A. N. , Savchenko V. G. 
Published: September 2021

Introduction. The Russian multicentre trial on treatment of Acute Lymphoblastic Leukaemia (ALL) in adults (RALL-2016) regulates a centralised detection of minimal residual disease (MRD) on days 70 (end of induction II), 133 (end of consolidation III) and 190 (end of consolidation V).Aim — the assessment of tumour cell clearance and normal B-cell precursor, mature B-cell and plasma cell dynamics.Materials and methods. The study period of December 2016 — August 2019 covered 59 B-ALL patients; the control cohort included four allogeneic blood stem cell donors. The MRD detection was performed with bone marrow samples in flow cytometry.Results. The patient majority have reached MRD-negativity at control timepoints, 60.4, 75.6 and 91.2% on days 70, 133 and 190, respectively. No correlation was observed between MRD values and tumour cell immunophenotype. B-cell precursors were undetected in 54.4, 38.8 and 59.4% patients on days 70, 133 and 190, respectively. Mature B-cells were fewer compared to donors’ on days 133 and 190. The relative plasma cell count did not differ significantly over therapy and between patients and donors.Conclusion. The RALL-2016 protocol facilitates MRD-negativity in the patient majority despite reduced cytostatic intensity.
Significance of TPMT and NUDT15 variants in 6-mercaptopurine metabolism in acute lymphoblastic leukaemia/lymphoma patients
Authors: Kotova E. S. , Gavrilina O. A. , Sudarikov A. B. 
Published: September 2021

Introduction. Among main curative substances in acute lymphoblastic leukaemia/lymphoma (ALL/LBL) is 6-mercaptopurine (6-MP). However, the severity of adverse reactions (ADRs) to this drug varies considerably among patients, which is sometimes conditioned by individual single nucleotide polymorphisms in key 6-MP metabolism enzyme genes.Aim — a literature review on the role of TPMT and NUDT15 gene variants in 6-MP metabolism in ALL/LBL.Main findings. The TPMT and NUDT15 genes encode enzymes mediating key steps of the 6-MP metabolism. The metabolites determine the 6-MP therapeutic and toxic properties, with ADRs emerging when their concentrations alter. A number of TPMT and NUDT15 single nucleotide polymorphisms are associated with varied activities of the encoded enzymes, and their allelic combinations condition functional and non-functional phenotypes. Non-functional variant carriers more likely develop toxicity on 6-MP treatment compared to functional phenotypes. Non-functional TPMT/NUDT15 carriers should have the 6-MP dosage reduced to minimise emerging ADRs.
Derecho penal del enemigo
Authors: Cruz López Midzon Rigoberto 
Published: September 2021

OBJETIVO: establecer si las normativas implementadas con el tiempo han permitido observar cambios profundos en el actuar de los individuos y que esta teoría no solo permita incrementar penas, quedando a la par de muchas otras que lo único que conllevan es la creación de más cuerpos normativos y la creación de más figuras delictivas. MÉTODO: analítico, sintético, inductivo, bibliográfico, jurídicos, documentales y de observación. RESULTADO: el Derecho Penal, es un derecho que permitió regular las conductas de los seres humanos dentro de una sociedad, restringiendo determinadas garantías constitucionales y derechos con la imposición de una pena contundente, actos que vienen regulados desde épocas antiguas cuando a los delincuentes se les imponían sanciones severas, que y su castigo consistía en quitarles la vida, sin embargo este derecho ha venido evolucionando desde con el pasar del tiempo, surgiendo diferentes teorías y ponientes, pero en la época actual se le ha dado mayor auge a una supuesta Teoría propuesta por el Filósofo Gunter Jakobs en lo que se refiere al Derecho Penal de Enemigo, que con la realización de actos terroristas en todo el mundo, da lugar que este gran filósofo forme una clasificación sobre los individuos en dos grupos siendo estos: personas y enemigos. En la antigüedad se consideraba a las personas enemigas, como un mal grave, comparado con un tumor canceroso, al cual había que eliminar de un cuerpo, es decir de la sociedad, es por esa razón que se proponen métodos de castigo para las personas que se consideren enemigos, a los que han sido castigados y no cumplen se les proponen que sean expulsados de las ciudades y en otros casos que se le de muerte como si fuera un incurable. CONCLUSIÓN: el derecho penal del enemigo es una manifestación empírica de la sociedad que su principal exponente observo en la sociedad a grupos delincuenciales capaces de conmover las bases fundamentales de la sociedad como lo son el bien común y la seguridad ciudadana, siendo necesaria la implementación de normas penales especiales con sanciones contundentes, para poder contrarrestar la delincuencia organizada.
The Metode Pendidikan Keteladanan Relevansi antara Qasidah Burdah dengan Teori Belajar Sosial Albert Bandura
Authors: Putri Intan Budiana , Muhid Abdul 
Published: September 2021

Dalam pendidikan Islam, keteladanan merupakan metode yang paling banyak terlihat hasilnya dan terbukti bersifat influentif di dalam membentuk moral, spiritual maupun sosial seorang anak. Qashidah Burdah melalui sya’ir-sya’ir nya yang begitu indah, yang menceritakan kisah Rasulullah yang terpilih, ditulis oleh seorang penyair yang alim. Merujuk pada teori social learning, perilaku dibentuk oleh hubungan interaksi klien dengan lingkungannya. Teknik modeling adalah salah satu teknik yang disusun oleh Albert Bandura. Tujuan dari penelitian ini adalah untuk menganalisis nilai-nilai pendidikan keteladanan dalam syair-syair qasidah burdah dan relevansinya terhadap teori belajar sosial Albert Bandura. Harapan dari penelitian ini adalah agar dapat dijadikan sebagai gagasan pendekatan dalam proses pembelajaran untuk mengembangkan kapasitas belajar dengan metode keteladanan. Bentuk penelitian ini adalah penelitian kualitatif yang menggunakan prosedur penelitian pustaka (Library Research). Di dalam penelitian ini ditemukan bahwa di dalam qasidah burdah terdapat kisah-kisah Rasulullah yang dapat kita jadikan sebagai salah satu metode pembelajaran, yaitu metode keteladanan.
Partnering Public and School Librarians for School Readiness Programming
Authors: Bloomer Bridget Alexis 
Published: September 2021

Partnerships from public and school librarians for programming can prove to be beneficial for connecting with the community. When collaborating for school readiness programs, such as a school readiness fair, the expertise can bring about the best resources and services that both the public and school librarians have to offer, alongside the other community leaders in early childhood education. The paper discusses how to create a school readiness fair based on a collaboration between public and school librarians. Covering aspects of networking, programs such as Every Child Ready to Read, and school curriculum standards, it brings about the best parts of collaborating for a community event.

Keywords: School Readiness, school libraries, public libraries, programming, kindergarten readiness
Coronal Microjets in Quiet-Sun Regions Observed with the Extreme Ultraviolet Imager on Board the Solar Orbiter
Authors: Hou Zhenyong , Tian Hui , Berghmans David , Chen Hechao , Teriaca Luca , Schühle Udo , Gao Yuhang , Chen Yajie , He Jiansen , Wang Linghua , Bai Xianyong 
Published: September 2021

Abstract
We report the smallest coronal jets ever observed in the quiet Sun with recent high-resolution observations from the High Resolution Telescopes (HRIEUV and HRILyα
) of the Extreme Ultraviolet Imager on board the Solar Orbiter (SO). In the HRIEUV (174 Å) images, these microjets usually appear as nearly collimated structures with brightenings at their footpoints. Their average lifetime, projected speed, width, and maximum length are 4.6 minutes, 62 km s−1, 1.0 Mm, and 7.7 Mm, respectively. Inverted-Y shaped structures and moving blobs can be identified in some events. A subset of these events also reveal signatures in the HRILyα
(H i Lyα at 1216 Å) images and the extreme ultraviolet images taken by the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO). Our differential emission-measure (EM) analysis suggests a multithermal nature and an average density of ∼1.4 × 109 cm−3 for these microjets. Their thermal and kinetic energies were estimated to be ∼3.9 × 1024 erg and ∼2.9 × 1023 erg, respectively, which are of the same order of the released energy predicted by the nanoflare theory. Most events appear to be located at the edges of network lanes and magnetic flux concentrations, suggesting that these coronal microjets are likely generated by magnetic reconnection between small-scale magnetic loops and the adjacent network field.
Subvertir la médecine, politiser la santé en quartiers populaires
Authors: Mariette Audrey , Pitti Laure 
Published: September 2021

Cet article étudie les processus de politisation de la médecine et de la santé en quartiers populaires durant les années 1970 en croisant une approche comparative internationale et une analyse des circulations transnationales de la critique sociale, entre la France et le Québec. Il se centre sur les dynamiques contestataires portées par différents groupes professionnels dans le champ de la santé – en particulier médecins et travailleur·euse·s sociales, en France, ou « organisateur.rice.s communautaires », au Québec – et sur les pratiques qu’ont pu recouvrir, à compter des années 1970, une médecine attentive à la question sociale ou une santé dite communautaire à l’échelle locale. L’article analyse d’abord ces expériences critiques du pouvoir médical en France durant les années 1970 pour rendre compte des similitudes et des différences avec celles menées à la même période au sein de la province canadienne francophone, dans une autre configuration politique et étatique. Il revient ensuite sur les circulations transnationales de ces formes de politisation de la médecine et de la santé, et étudie leurs évolutions au tournant des années 1980. Ce faisant, l’article discute la thèse de la mise sous silence de la critique sociale par le néolibéralisme à compter des années 1980.
La guerre où se joue le droit à la vie
Authors: Papyan Nariné 
Published: September 2021

L’auteure nous fait part de son expérience actuelle de psychologue auprès des rescapés de la guerre entre le Haut-Karabakh et l’Azerbaïdjan. Avec des vignettes cliniques, elle montre comment ce conflit, court dans le temps mais très lourd en bilan humain, est d’un type nouveau. Comment remettre de l’humanisme dans l’immédiat après-coup ?
Closing the knowledge gap in Malaysian pharmacists: A virtual Allergic Rhinitis Boot Camp initiative
Authors: Abdullah Baharudin , Ramli Ramiza Ramza , Shukri Norasnieda Md , Mohamad Sakinah 
Published: September 2021

Background: In primary care, general practitioners (GPs) and pharmacists are at the frontline to identify, classify and manage patients suffering from allergic rhinitis (AR). The Allergic Rhinitis and its impact on Asthma (ARIA) guidelines aid clinicians in disease management by providing evidence-based recommendations. A recently published ASEAN primary care survey demonstrated that the awareness of ARIA guidelines was high among GPs but notably lower in pharmacists. Hence, this study seeks to evaluate the effectiveness of a Boot Camp education initiative in bridging the unmet needs in pharmacist awareness and education.Methods: The boot camp was organised as a virtual event. The participants answered the same questionnaire before (pre-assessment) and immediately after (post-assessment) the boot camp session. Statistical analysis was performed on the data paired between the pre- and post- assessments using SPSS v. 25.0 software.Results: The boot camp survey results showed that second-generation oral antihistamines and allergen avoidance are the most preferred options for AR treatment in pharmacy practice, irrespective of the disease severity. In both pre- and post-assessments, efficacy was ranked as the most important factor considered for choosing an antihistamine and which affects patient adherence. With the boot camp initiative, there was a statistically significant increase in awareness about the patient profiling tool (from 31.6% to 88.2%) and ARIA guidelines (from 40.4% to 91.2%) among the pharmacists (p<0.05). The proportion of pharmacists who were able to identify, classify and refer AR patients was significantly increased in post-assessment (p<0.05). Post the boot camp, among the proportion of pharmacists (91.2%) who were already aware of ARIA, a high percentage of them further agreed that ARIA guidelines were useful in identifying and treating patients with AR, as well as classifying AR, respectively (97.6%, 95.2%, and 93.5%).Conclusions: Based on improvements in knowledge and understanding of disease management post assessment, the Allergic Rhinitis Boot Camp initiative is effective and relevant to pharmacy practice. Outreach programs like this reiterate the emphasis on patient compliance and importance of utilizing ARIA guidelines in pharmacy practice that facilitates better management of AR in primary care.
False-Positive Rates and Associated Risk Factors on the Vestibular-Ocular Motor Screening and Modified Balance Error Scoring System in US Military Personnel
Authors: Kontos Anthony P. , Monti Katrina , Eagle Shawn R. , Thomasma Eliot , Holland Cyndi L. , Thomas Drew , Bitzer Hannah B. , Mucha Anne , Collins Michael W. 
Published: September 2021

Context
In 2018, the US military developed the Military Acute Concussion Evaluation-2 (MACE-2) to inform the acute evaluation of mild traumatic brain injury (mTBI). However, researchers have yet to investigate false-positive rates for components of the MACE-2, including the Vestibular-Ocular Motor Screening (VOMS) and modified Balance Error Scoring System (mBESS), in military personnel.

Objective
To examine factors associated with false-positive results on the VOMS and mBESS in US Army Special Operations Command (USASOC) personnel.

Design
Cross-sectional study.

Setting
Military medical clinic.

Patients or Other Participants
A total of 416 healthy USASOC personnel completed the medical history, VOMS, and mBESS evaluations.

Main Outcome Measure(s)
False-positive rates for the VOMS (≥2 on VOMS symptom items, &gt;5 cm for near point of convergence [NPC] distance) and mBESS (total score &gt;4) were determined using χ2 analyses and independent-samples t tests. Multivariable logistic regressions (LRs) with adjusted odds ratios (aORs) were performed to identify risk factors for false-positive results on the VOMS and mBESS. The VOMS item false-positive rates ranged from 10.6% (smooth pursuits) to 17.5% (NPC). The mBESS total score false-positive rate was 36.5%.

Results
The multivariable LR model supported 3 significant predictors of VOMS false-positives, age (aOR = 1.07; 95% CI = 1.02, 1.12; P = .007), migraine history (aOR = 2.49; 95% CI = 1.29, 4.81; P = .007), and motion sickness history (aOR = 2.46; 95% CI = 1.34, 4.50; P = .004). Only a history of motion sickness was a significant predictor of mBESS false-positive findings (aOR = 2.34; 95% CI = 1.34, 4.05; P = .002).

Conclusions
False-positive rates across VOMS items were low and associated with age and a history of mTBI, migraine, or motion sickness. False-positive results for the mBESS total score were higher (36.5%) and associated only with a history of motion sickness. These risk factors for false-positive findings should be considered when administering and interpreting VOMS and mBESS components of the MACE-2 in this population.