bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cedecea lapagei An Extremely Rare Uropathogen: A Case Report and Review of the Literature
Authors: Mohamed Abdikarim Hussein , Mohamud Hussein Ali 
Published: February 2021

Abstract
Background: Gram-negative enterobacteria are the most common cause of urinary tract infections. Cedecea is a new separate genus in the family enterobacteriaceae, and it is a very rare pathogen that was primarily found in the respiratory tract. Cedecea lapagei is a very rare pathogen of urinary tract infections. To the best of our knowledge, this is the first case report in the world reported in English literature. Case presentation: A 55 years old man with chronic renal failure, poorly controlled diabetes mellitus, and hypertension presented with acute exacerbations of renal failure and irritative voiding symptoms. After stabilization and empirical antibiotic therapy with Ceftriaxone, the patient’s condition was not improved and deteriorated progressively. After the request of urine culture, the culture was isolated, an extremely rare uropathogen recently recognized by the Centers for Disease Control and Prevention (CDC); the Cedecea lapagei. Cedecea lapagei identification had been done using Eosin methylene blue agar (EMB). Gram-negative lipase positive bacteria with bacillus in shape, motile in nature that is non-spore-forming, and non-encapsulated enterobacteria with the final result of >100,000 colony-forming units per ml of Cedecea lapagei were isolated. Mueller-Hinton agar had been used to perform antimicrobial sensitivity and resistance. The pathogen was extensively resistant to the extended-spectrum beta-lactamases antibiotics and extended-spectrum beta-lactam inhibitors while carbapenems, fluoroquinolones, aminoglycosides, and Trimethoprim-sulfamethoxazole showed a higher sensitivity rate. Conclusion: The treatment of Cedecea lapagei infections represents a challenging issue due to its multi-drug resistant and extensive drug resistance patterns to a variety of antimicrobial classes, such as extended-spectrum beta-lactamases, cephalosporins, and beta-lactam inhibitors. Antimicrobial treatment should be aligned with the culture findings once available.
Syntheses and Anticancer Activities of Novel Glucosylated (-)-Epigallocatechin-3-Gallate Derivatives Linked via Triazole Rings
Authors: Zi Cheng-Ting , Shi Bo-Ya , Wang Ze-Hao , Zhang Ning , Xie Yin-Rong , Sun Xiu-Li , Yang Hao-Nan , Wu Yi-Long , Wang Xuan-Jun , Sheng Jun 
Published: February 2021

Abstract
Novel glucosylated (-)-epigallocatechin-3-gallate derivatives 10 – 13 having the EGCG analogues conjugated to the D-glucosyl azide were synthesized by carrying out the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, and were evaluated for their cytotoxicities against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) using MTT assays. Compounds 10 and 11 showed the highest levels of cytotoxicity against the HL-60 cells with IC50 values of 4.57 μM and 3.78 μM, respectively, and showed moderate selectivity towards cancer cell lines. Compound 11 was also shown to induce apoptosis in HL-60 cells. Most notably, inclusion of the perbutyrylated glucose residue in an EGCG derivative was concluded to lead to increased anticancer activity.
Is Therapeutic Inertia Present in hyperglycaemia, Hypertension and Hypercholesterolaemia Management among Adults with type 2 Diabetes in three Health Clinics in Malaysia? A Retrospective Cohort Study
Authors: Chew Boon How , Hussain Husni , Supian Ziti Akthar 
Published: February 2021

Abstract
Background: Good-quality evidence has shown that early glycaemic, blood pressure and LDL-cholesterol control in people with type 2 diabetes (T2D) leads to better outcomes. In spite of that, diseases control have been inadequate globally, and therapeutic inertia could be one of the main cause. Evidence on therapeutic inertia has been lacking at primary care setting. This retrospective cohort study aimed to determine the proportions of therapeutic inertia when treatment targets of HbA1c, blood pressure and LDL-cholesterol were not achieved in adults with T2D at three public health clinics in Malaysia.Methods: The index prescriptions were those that when the annual blood tests were reviewed. Prescriptions of medication were verified, compared to the preceding prescriptions and classified as 1) no change, 2) stepping up and 3) stepping down. The treatment targets were HbA1c < 7.0% (53 mmol/mol), blood pressure (BP) < 140/90 mmHg and LDL-cholesterol < 2.6 mmol/L. Therapeutic inertia was defined as no change in the medication use in the present of not reaching the treatment targets. Descriptive, univariable, multivariable logistic regression and sensitive analyses were conducted. Results: A total of 552 cohorts were available for the assessment of therapeutic inertia (78.9% completion rate). The mean (SD) age and diabetes duration were 60.0 (9.9) years and 5.0 (6.0) years, respectively. High therapeutic inertia were observed in oral anti-diabetic (61-72%), anti-hypertensive (34-65%) and lipid-lowering therapies (56-77%), and lesser in insulin (34-52%). Insulin therapeutic inertia was more likely among those with shorter diabetes duration (adjusted OR 0.9, 95% CI 0.87, 0.98). Those who did not achieve treatment targets were less likely to experience therapeutic inertia: HbA1c ≥ 7.0%: adjusted OR 0.10 (0.04, 0.24); BP ≥ 140/90 mmHg: 0.28 (0.16, 0.50); LDL-cholesterol ≥ 2.6 mmol/L: 0.37 (0.22, 0.64). Conclusions: Although therapeutic intensifications were more likely in the present of non-achieved treatment targets but the proportions of therapeutic inertia were high. Possible causes of therapeutic inertia were less of the physician behaviours but may be more of patient-related non-adherence or non-availability of the oral medications and these require urgent identification and rectification to improve disease control, avoiding detrimental health implications and costly consequences.
Pheromone Mediated Sexual Reproduction of Pennate Diatom Cylindrotheca Closterium
Authors: Klapper Franziska , Audoor Sien , Vyverman Wim , Pohnert Georg 
Published: February 2021

Abstract
Benthic diatoms dominate primary production in marine subtidal and intertidal environments. Their extraordinary species diversity and ecological success is thought to be linked with their motility and predominantly heterothallic sexual reproduction. Little is known about pheromone involvement during mating of pennate diatoms. Here we describe pheromone guided mating in the coastal raphid diatom Cylindrotheca closterium. We show that the two mating types (mt+ and mt¯) have distinct functions. Similar to other benthic diatoms, mt+ cells are searching for the mt¯ cells to pair. To enhance mating efficiency mt¯ exudes an attraction pheromone, which we proved by establishing a novel capillary assay. Further, two more pheromones produced by mt¯ promote the sexual events. One arrests the cell cycle progression of mt+ while the other induces gametogenesis of mt+. We suggest that C. closterium shares a functionally similar pheromone system with other pennate diatoms like Seminavis robusta and Pseudostaurosira trainorii which synchronize sexual events and mate attraction. Remarkably, we found no evidence of mt+ producing pheromones, which differentiates C. closterium from other pennates and suggests a less complex pheromone system in C. closterium.
Elucidating the Onset of Plasticity in Sliding Contacts Using Differential EBSD Tomography
Authors: Eder Stefan , Grützmacher Philipp G , Ripoll Manel Rodríguez , Belak Jim 
Published: February 2021

Abstract
Depending on the mechanical and thermal energy introduced to a dry sliding interface, the near-surface regions of the mated bodies may undergo plastic deformation. In this work, we use "differential EBSD tomography" to highlight changes to the microstructure near tribological fcc alloy surfaces, allowing us to detect subtle differences in lattice orientation and small distances in grain boundary migration. The analysis approach compares electron backscatter diffraction images generated from large-scale molecular dynamics simulations with their undeformed counterparts via a simple image analysis filter. We use our visualization method to discuss the acting microstructural mechanisms in a load- and time-resolved fashion, focusing on sliding conditions that lead to twinning, partial lattice rotation, and grain boundary dominated processes. Extracting and laterally averaging the color saturation value of the generated tomographs allows us to produce quantitative time- and depth-resolved maps that give a good overview of the progress and severity of near-surface deformation. Corresponding maps of the lateral standard deviation in the color saturation show evidence of homogenization processes occurring in the tribologically loaded microstructure, frequently leading to the formation of a well-defined separation between deformed and undeformed regions. When integrated into a computational materials engineering framework, our approach could help optimize material design for tribological and other deformation problems.
On the Optimal Energy Efficiency and Spectral Efficiency Trade-Off of CF Massive MIMO SWIPT System
Authors: Li Na , Gao Yuan Yuan , Xu Kui 
Published: February 2021

Abstract
This paper studies a cell-free (CF) massive multi-input multi-output (MIMO) simultaneous wireless information and power transmission (SWIPT) system and proposes a user-centric (UC) access point (AP) selection method and a trade-off performance optimization scheme for spectral efficiency and energy efficiency. In this system, users have both energy harvesting and information transmission functions, and according to the difference between energy harvesting and information transmission, a flexible AP selection scheme is designed. This paper analyses the trade-off between energy efficiency and spectral efficiency, proposes an evaluation index that takes into account both energy efficiency and spectral efficiency, and jointly optimizes the AP selection scheme and the uplink (UL) and downlink (DL) time switching ratio to maximize the trade-off performance. Then, the non-convex problem is converted to a geometric planning (GP) problem to solve. The simulation results show that by implementing a suitable AP selection scheme and UL and DL time allocation, the information processing scheme on the AP side has a slight loss in spectral efficiency, but the energy efficiency is close to the performance of global processing on the central processing unit (CPU).
Assessment of the Relationship between the Maxillary Sinus and the Canine Root tip using Cone Beam Computed Tomography
Authors: Khojastepour Leila , Movahhedian Najmeh , Zolghadrpour Mohadeseh 
Published: February 2021

Abstract
Background: The purpose of the present study is to investigate the frequency and amount of extension of the maxillary sinus to the anterior region and to evaluate the vertical distance between the maxillary sinus floor and canine apices.Methods: Cone beam computed tomographic images of 300 individuals (154 males and 146 females) over 20 years (with mean age of 35.12 ± 8.40 years) were evaluated. The subjects were categorized into three age groups (20-30, 30-40 and 40-50 years). When maxillary sinus extended to the canine area, the vertical distance between them were recorded and their relationship were classified into three types: I (> 2 mm distance), II (2 mm < distance or in-contact) and III (interlock). Results: 413 out of 600 maxillary sinuses (68.8%) were extended into the canine area or beyond. Among them, 15 maxillary sinuses pneumatized into the incisor area (2.5%). The prevalence of the maxillary sinuses extended to the anterior region of the jaw was not significantly different between genders, but it was significantly less frequent in older age group and more frequent in the left side. The mean amount of anterior extension of maxillary sinus (mm) was significantly lower in older age group. Type I was the most frequent vertical relationship between the maxillary sinuses and canine apices with no significant difference in gender, side and age groups.Conclusions: Most of the maxillary sinuses extended to the canine area. Maxillary sinus extended into incisor area with the frequency of 2.5% . The amount of extension of the maxillary sinus to the anterior region and its vertical distance with canine apices decreased in older age group.
Bathymetry Inversion Using Vertical Deflections: a Case Study in South China Sea
Authors: Wan Xiaoyun , Liu Bo , Sui Xiaohong , Annan Richar Fiifi , Min Yijun 
Published: February 2021

Abstract
As an alternative method, an algorithm for bathymetry inversion using vertical deflections is proposed. Firstly, the formulas for the bathymetry inversion from north and east components of vertical deflections are derived and the data processing is introduced. Then a local area in the South China Sea is selected as an example to experiment the method. The bathymetry inversion based on gravity anomaly was also conducted for a comparison. The results show that the bathymetry derived from the north component of the vertical deflections have almost the same accuracy as that derived from gravity anomalies and the results derived from the east component have the poorest accuracy. The experiment’s results also show that accuracy of the derived bathymetry can be improved if the fitting parameters are adjusted according to the water depths. In summary, among the gravity field products used in this study, although the gravity anomaly yielded the best performance in the bathymetry inversion, the vertical defections can still be used as supplements, especially in areas where accurate vertical deflections exist. This is because deriving gravity anomaly from altimetry observations needs additional data and calculation efforts.
An Assessement of the Air Quality in Apple Warehouses : New Record of Aspergillus Europaeus, Aspergillus Pulverulentus, Penicillium Allii and Penicllium Sumatraense as Decay Agents
Authors: SMIRI Marwa , KHEIREDDINE Amina , Hammami Rania , ROUISSI Mustapha , Espeso Eduardo Antonio , SADFI-ZOUAOUI Najla 
Published: February 2021

Abstract
Airborne fungi are one of the major components of aeromycobiota known to produce several fungal diseases in fruits. Their presence in indoor environment of warehouses may limit the storage period of apples. Qualitative and quantitative analysis of airborne fungal spores were conducted using gravity settling techniques to detect fungal airspora present in the atmosphere of two apple warehouses in Tunisia. In this study, 375 fungal isolates were obtained and purified. Phylogenetic analysis of Calmodulin, beta-tubulin and ITS regions coupled with phenotypic characterization helped to identify fifteen fungal species. Penicillium exhibited the highest diversity with ten species detected (Penicillium expansum, Penicillium allii, Penicillium polonicum, Penicillium solitum, Penicillium chrysogenum, Penicillium steckii, Penicillium viridicatum, Penicillium sumatraense, Penicillium italicum and Penicillium citrinum), followed by four species of Aspergillus genus (Aspergillus niger, Aspergillus pulverulentus, Aspergillus flavus and Aspergillus europaeus) and Alternaria alternata. In vivo experiments confirmed the pathogenicity of thirteen species at room temperature and under cold-storage conditions. Among them, A. europaeus, A. pulverulentus, P. allii and P. Sumatraense were described for the first time as pathogenic on apples. The present study identified the major airborne fungi associated with postharvest rot in apple storage facilities in Tunisia and may help in efficient control of post-harvest and storage fruit diseases.
Review Microstructure of Nickel-Based Single-Crystal CMSX-4 Superalloy after Electrochemical Machining
Authors: Mehrvar Ali , Mirak Alireza , Motamedi Mohsen 
Published: February 2021

Abstract
A special position has been created for using the nickel-based single-crystal CMSX-4 superalloy at high temperatures due to the improved mechanical properties of this material and the absence of grain boundary in the crystal lattice. Also, electrochemical machining can be an effective method for machining this superalloy due to its unique performance in metal machining, like creating stress-free surfaces, high-level surface smoothness, and machining of complex geometries. This single crystal superalloy's microstructure consists of three phases: Gamma, Gamma prime, and a bit of carbide. Gamma prime is distributed cubically and homogeneously in the Gamma field without any boundaries and as a single crystal. It is essential not to change the microstructure after the production process or machining. In the present research, electrochemical machining was performed on CMSX-4 single crystal superalloy. The workpiece's microstructure was then investigated before and after electrochemical machining using scanning electron microscopy and EDS analysis from two sides. No changes were seen in CMSX-4 infrastructure after electrochemical machining EDS analysis and Images.
Factors Facilitating Destructive Behaviors in Nurses Towards Other Healthcare Workers in Iranian Healthcare Organizations: a Qualitative Study
Authors: Afzali Mahboobeh , Mokhtari Jamileh , Ebadi Abbas , Rezaiye Milad 
Published: February 2021

Abstract
Introduction: Destructive behavior is considered a chronic, deep-rooted problem in the profession of nursing. Academic articles addressing the issue have existed in literature for the past three decades. Destructive behavior costs healthcare institutions in terms of funds, and it has unpleasant impacts such as escalating absenteeism, reduced productivity, and reduced quality of care for the patients. Finding ways to eliminate such behavior requires a perception and full recognition of the factors that cause and promote it. Since destructive behavior is a complex, multi-dimensional concept that is dependent on context and the culture of the particular organization or society, this research concentrates on the factors shaping such behavior and promoting it in Iranian healthcare institutions.Material and Methods: The present study makes use of the conventional content analysis method to explore the views and experiences of nurses and other healthcare workers by interviewing 30 individuals and one focus group and recording 120 hours of observation in 6 hospitals around the capital city of Tehran comprising 2 private facilities and 4 state hospitals. The interviews were all recorded, transcribed and analyzed.Results: Through data analysis 26 subcategories and 5 main categories of underlying causes, namely, inappropriate organizational mindset, ineffectual management, complex conditions of work in the nursing occupation, unprofessional standards of education and training for nurses, and personal contributions were identified.Conclusion: The present study demonstrates that the main factors promoting destructive behavior in Iranian healthcare organizations are the organizations themselves. To solve the problem of destructive behaviors organizational problems such as ineffectual management, shortage of facilities and infrastructures, a chronic human resource shortage, institutionalized injustice stemming from a state of physicians’ oligarchy, favoritism as a cultural trait, and systematic bullying must first be tackled.
One-year Clinically Important Deterioration and Long-Term Clinical Course in Japanese patients with COPD: A Multicenter Observational Cohort Study
Authors: Abe Yuki , Suzuki Masaru , Makita Hironi , Kimura Hirokazu , Shimizu Kaoruko , Konno Satoshi , Nishimura Masaharu 
Published: February 2021

Abstract
Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with a complex progression of many clinical presentations, and clinically important deterioration (CID) has been proposed in the Western studies as a composite endpoint of disease progression. The aim of this study was to investigate the relationships between 1-year CID and the following long-term clinical outcomes in Japanese patients with COPD who have been reported to have different characteristics compared to the Westerners.Methods: Among Japanese patients with COPD enrolled in the Hokkaido COPD cohort study, 259 patients who did not drop out within the first year were analyzed in this study. Two definitions of CID were used. Definition 1 comprised ≥100 mL decrease in forced expiratory volume in 1 second (FEV1), ≥4-unit increase in St George’s Respiratory Questionnaire (SGRQ) score from baseline, or moderate or severe exacerbation. For Definition 2, the thresholds for the FEV1 and SGRQ score components were doubled. The presence of CID was evaluated within the first year from enrollment, and analyzed the association of the presence of CID with following 4-year risk of exacerbations and 9-year mortality.Results: Patients with CID using Definition 1, but not any single CID component, during the first year had a significantly worse mortality compared with those without CID. Patients with CID using Definition 2 showed a similar trend on mortality, and had a shorter exacerbation-free survival compared with those without CID.Conclusions: Adoption of CID is a beneficial and useful way for the assessment of long-term disease progression and clinical outcomes even in Japanese population with COPD. The definition of CID might be optimized according to the characteristics of COPD population and the observation period for CID.
Efficacy and Safety of Specific Immunotherapy with Aeroallergens in the Management of Atopic Dermatitis: A Systematic Review and Meta-analysis
Authors: Prakoeswa Cita Rosita Sigit , Anggraeni Sylvia , Damayanti Damayanti , Umborowati Menul Ayu , Riswanto Cintya Dipta , Rhatomy Sholahuddin , Notobroto Hari Basuki , Endaryanto Anang , Effendy Isaak 
Published: February 2021

Abstract
Background: Specific immunotherapy with standardized aeroallergens can reduce symptoms and increase the quality of life for related allergy patients. This therapy is still controversial for atopic dermatitis (AD). Hence, a meta-analysis to assess efficacy and safety of specific immunotherapy with aeroallergens on patients with AD could provide a clear oversight on advantages and limitations of such treatment.Methods: We systematically searched PubMed, DOAJ, and Cochrane Central Register of Controlled Trials databases for relevant studies published Randomized controlled trials (RCTs) up to October 2020. Studies involving all ages and gender with AD who treated with specific immunotherapy employing aeroallergens compared with placebo/control.Results: Seven studies RCTs were identified with 832 participants. Significantly decreased of SCORAD values favoring immunotherapy were observed (MD: -5.42; 95% CI - 10.31, -0.52; p=0.03). VAS score was significantly decrease (MD: -1.21; 95% CI -2.10, -0.31; p=0.008). However, immunotherapy showed no significant local and systemic adverse events ((RR 1.77; 95% CI 0.98, 3.19, p=0.06); (RR 0.69; 95% CI 0.16, 3.01, p=0.62)) and IgG4 Dermatophagoides farinae (MD: 92.36, 95% CI -89.14,273.87; p=0.32). Conclusion: Our five years meta-analysis included small number studies, indicated moderate-level evidence for immunotherapy with standardized extract of aeroallergens is effective and safe for AD patients.