bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the Relationship Between History of Arrest and Self-reported Cardiovascular Conditions
Authors: Bellerose Meghan , Yilin Diandian , Rowell-Cunsolo Tawandra L 
Published: July 2021

Abstract

Background
Formerly incarcerated Americans are believed to have increased risk of hypertension and cardiovascular disease, yet the impact of lower-level criminal legal system exposures, such as arrests, on cardiovascular health are less clear.

Methods
We explored the relationship between lifetime history of arrest and self-report of ever having been diagnosed with hypertension or a heart condition using data from the 2018 National Survey on Drug Use and Health (NSDUH). Survey-weighted Poisson regression models with robust variance, adjusted for age group, sex, race/ethnicity, education, past year mental illness, smoking history, and past year substance use disorder, were used to estimate adjusted prevalence ratios (PRs).

Results
Among the 13,583 respondents, 17.0% reported a history of arrest, among whom 45.2% also reported a hypertension diagnosis and 24.4% reported a heart condition. Among those without a history of arrest, 46.7% reported a hypertension diagnosis and 25.2% reported a heart condition diagnosis. The adjusted models did not show evidence that history of arrest is associated with self-reported hypertension (adjusted PR 1.0; 95% confidence interval [CI] 0.93, 1.07, P = 0.937) or self-reported heart condition (1.0; 95% CI 0.91, 1.11, P = 0.915).

Conclusions
We did not find evidence that history of arrest, a lower-level criminal legal system exposure, is associated with self-reported hypertension or heart conditions.
Clustering of genes from microarray data using hierarchical projective adaptive resonance theory: a case study of tuberculosis
Authors: Zhang Xu , Kim Kiyeon , Ye Zhiqiang , Wu Jianhong , Qiao Feng , Zou Quan 
Published: July 2021

Abstract
We propose the hierarchical Projective Adaptive Resonance Theory (PART) algorithm for classification of gene expression data. This algorithm is realized by combing transposed quasi-supervised PART and unsupervised PART. We develop the corresponding validation statistics for each process and compare it with other clustering algorithms in a case study of tuberculosis (TB). First, we use sample-based transposed quasi-supervised PART to obtain optimal clustering results of samples distinguished by time post-infection and the representative genes for each cluster including up-regulated, down-regulated and stable genes. The up- and down-regulated genes show more than 90% similarity to the result derived from Linear Models for Microarray Data and are verified by weighted k-nearest neighbor model on TB projection. Second, we use gene-based unsupervised PART algorithm to cluster these representative genes where functional enrichment analysis is conducted in each cluster. We further confirm the main immune response of human macrophage-like THP-1 cells against TB within 2 days is type I interferon-mediated innate immunity. This study demonstrates how hierarchical PART algorithm analyzes microarray data. The sample-based quasi-supervised PART extracts representative genes and narrows down the shortlist of disease-relevant genes and gene-based unsupervised PART classifies representative genes that help to interpret immune response against TB.
Electrocorticography and stereo EEG provide distinct measures of brain connectivity: implications for network models
Authors: Bernabei John M , Arnold T Campbell , Shah Preya , Revell Andrew , Ong Ian Z , Kini Lohith G , Stein Joel M , Shinohara Russell T , Lucas Timothy H , Davis Kathryn A , Bassett Danielle S , Litt Brian 
Published: July 2021

AbstractBrain network models derived from graph theory have the potential to guide functional neurosurgery, and to improve rates of post-operative seizure freedom for patients with epilepsy. A barrier to applying these models clinically is that intracranial EEG electrode implantation strategies vary by centre, region and country, from cortical grid & strip electrodes (Electrocorticography), to purely stereotactic depth electrodes (Stereo EEG), to a mixture of both. To determine whether models derived from one type of study are broadly applicable to others, we investigate the differences in brain networks mapped by electrocorticography and stereo EEG in a cohort of patients who underwent surgery for temporal lobe epilepsy and achieved a favourable outcome. We show that networks derived from electrocorticography and stereo EEG define distinct relationships between resected and spared tissue, which may be driven by sampling bias of temporal depth electrodes in patients with predominantly cortical grids. We propose a method of correcting for the effect of internodal distance that is specific to electrode type and explore how additional methods for spatially correcting for sampling bias affect network models. Ultimately, we find that smaller surgical targets tend to have lower connectivity with respect to the surrounding network, challenging notions that abnormal connectivity in the epileptogenic zone is typically high. Our findings suggest that effectively applying computational models to localize epileptic networks requires accounting for the effects of spatial sampling, particularly when analysing both electrocorticography and stereo EEG recordings in the same cohort, and that future network studies of epilepsy surgery should also account for differences in focality between resection and ablation. We propose that these findings are broadly relevant to intracranial EEG network modelling in epilepsy and an important step in translating them clinically into patient care.
Prevalence and factors associated with hyperkalaemia in stable kidney transplant recipients
Authors: Smyrli Maria , Sarafidis Pantelis A , Loutradis Charalampos , Korogiannou Maria , Boletis Ioannis N , Marinaki Smaragdi 
Published: July 2021

ABSTRACT

Background
Hyperkalaemia is a frequent and potentially life-threatening condition in patients with chronic kidney disease (CKD). Even after successful kidney transplantation (KTx), KTx recipients have mild to severe CKD. Moreover, they share comorbid conditions and frequently use medications that predispose to hyperkalaemia. This study aimed to examine the prevalence and factors associated with hyperkalaemia in this population.

Methods
Over a pre-specified period of 6 months (1 September 2019 to 31 March 2020), we recorded in cross-sectional fashion information on serum potassium (K+) and relevant demographics, comorbidities, medications, laboratory and transplant-associated variables in clinically stable KTx recipients attending the Transplant Outpatient Clinic of our Department. Ηyperkalaemia was classified as follows: serum K+ level &gt;5.0 mEq/L; and further as &gt;5.0 mEq/L with concomitant use of sodium (Na+) polystyrene sulphonate; serum K+ ≥5.2 mEq/L; serum K+ ≥5.5 mEq/L. Univariate and multiple logistic regression analyses were used to identify factors associated with serum K+ &gt;5.0 mEq/L.

Results
The study population consisted of 582 stable KTx recipients, 369 (63.4%) males, aged 52.4 ± 13.5 years, with estimated glomerular filtration rate (eGFR) of 55.8 ± 20.1 mL/min/1.73 m2 transplanted for &gt;1 year. The prevalence of hyperkalaemia defined as K+ &gt;5.0 mEq/L; &gt;5.0 mEq/L and use of Na+ polystyrene sulphonate; K+ ≥5.2; or K+ ≥5.5 mEq/L, was: 22.7, 22.7, 14.4 and 4.1% (132, 132, 84 and 24 patients), respectively. In multivariate analysis, male gender [odds ratio (OR) = 2.020, 95% confidence interval (CI) 1.264–3.227] and use of renin–angiotensin–aldosterone system (RAAS) blockers (OR = 1.628, 95% CI 1.045–2.536) were independently associated with hyperkalaemia, while higher eGFR (OR = 0.967, 95% CI 0.955–0.979) and use of non-K+-sparing diuretics (OR = 0.140, 95% CI 0.046–0.430) were associated with lower odds of the disorder.

Conclusions
The prevalence of mild hyperkalaemia in stable KTx recipients is relatively high but that of moderate or severe hyperkalaemia is low. Among a wide range of factors studied, only male gender and RAAS blockade were associated with increased odds of hyperkalaemia, while higher eGFR and diuretics were associated with decreased odds of hyperkalaemia.
Management of post-transplant diabetes mellitus: an opportunity for novel therapeutics
Authors: Montero Nuria , Oliveras Laia , Soler Maria José , Cruzado Josep Maria 
Published: July 2021

ABSTRACT
Post-transplant diabetes mellitus (PTDM) is a common problem after kidney transplantation (KT), occurring in 50% of high-risk recipients. The clinical importance of PTDM lies in its impact as a significant risk factor for cardiovascular and chronic kidney disease (CKD) after solid organ transplantation. Kidney Disease: Improving Global Outcomes (KDIGO) has recently updated the treatment guidelines for diabetes management in CKD with emphasis on the newer antidiabetic agents such as dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists and sodium–glucose co-transporter 2 inhibitors as add-on therapy to metformin. Given all these new diabetes treatments and the updated KDIGO guidelines, it is necessary to evaluate and give guidance on their use for DM management in KT recipients. This review summarizes the scarce published literature about the use of these new agents in the KT field. In summary, it is absolutely necessary to generate evidence in order to be able to safely use these new treatments in the KT population to improve blood glucose control, but specially to evaluate their potential cardiovascular and renal benefits that would seem to be independent of blood glucose control in PTDM patients.
The complete mitogenome assemblies of 10 diploid potato clones reveal recombination and overlapping variants
Authors: Achakkagari Sai Reddy , Tai Helen H , Davidson Charlotte , De Jong Hielke , Strömvik Martina V 
Published: July 2021

Abstract
The potato mitogenome is complex and to understand various biological functions and nuclear–cytoplasmic interactions, it is important to characterize its gene content and structure. In this study, the complete mitogenome sequences of nine diploid potato clones along with a diploid Solanum okadae clone were characterized. Each mitogenome was assembled and annotated from Pacific Biosciences (PacBio) long reads and 10X genomics short reads. The results show that each mitogenome consists of multiple circular molecules with similar structure and gene organization, though two groups (clones 07506-01, DW84-1457, 08675-21 and H412-1 in one group, and clones W5281-2, 12625-02, 12120-03 and 11379-03 in another group) could be distinguished, and two mitogenomes (clone 10908-06 and OKA15) were not consistent with those or with each other. Significant differences in the repeat structure of the 10 mitogenomes were found, as was recombination events leading to multiple sub-genomic circles. Comparison between individual molecules revealed a translocation of ∼774 bp region located between a short repeat of 40 bp in molecule 3 of each mitogenome, and an insertion of the same in molecule 2 of the 10908-06 mitogenome. Finally, phylogenetic analyses revealed a close relationship between the mitogenomes of these clones and previously published potato mitogenomes.
Long-term 5-year outcome of the randomized IMPRESS in severe shock trial: percutaneous mechanical circulatory support vs. intra-aortic balloon pump in cardiogenic shock after acute myocardial infarction
Authors: Karami Mina , Eriksen Erlend , Ouweneel Dagmar M , Claessen Bimmer E , Vis M Marije , Baan Jan , Beijk Marcel , Packer Erik J S , Sjauw Krischan D , Engstrom Annemarie , Vlaar Alexander , Lagrand Wim K , Henriques Jose P S 
Published: July 2021

Abstract

Aims
To assess differences in long-term outcome and functional status of patients with cardiogenic shock (CS) treated by percutaneous mechanical circulatory support (pMCS) and intra-aortic balloon pump (IABP).

Methods and results
Long-term follow-up of the multicentre, randomized IMPRESS in Severe Shock trial (NTR3450) was performed 5-year after initial randomization. Between 2012 and 2015, a total of 48 patients with severe CS from acute myocardial infarction (AMI) with ST-segment elevation undergoing immediate revascularization were randomized to pMCS by Impella CP (n = 24) or IABP (n = 24). For the 5-year assessment, all-cause mortality, functional status, and occurrence of major adverse cardiac and cerebrovascular event (MACCE) were assessed. MACCE consisted of death, myocardial re-infarction, repeat percutaneous coronary intervention, coronary artery bypass grafting, and stroke. Five-year mortality was 50% (n = 12/24) in pMCS patients and 63% (n = 15/24) in IABP patients (relative risk 0.87, 95% confidence interval 0.47–1.59, P = 0.65). MACCE occurred in 12/24 (50%) of the pMCS patients vs. 19/24 (79%) of the IABP patients (P = 0.07). All survivors except for one were in New York Heart Association Class I/II [pMCS n = 10 (91%) and IABP n = 7 (100%), P = 1.00] and none of the patients had residual angina. There were no differences in left ventricular ejection fraction between the groups (pMCS 52 ± 11% vs. IABP 48 ± 10%, P = 0.53).

Conclusions
In this explorative randomized trial of patients with severe CS after AMI, there was no difference in long-term 5-year mortality between pMCS and IABP-treated patients, supporting previously published short-term data and in accordance with other long-term CS trials.
Effectiveness and safety of non-vitamin K antagonist oral anticoagulants and warfarin in atrial fibrillation: a Scandinavian population-based cohort study
Authors: Halvorsen Sigrun , Johnsen Søren P , Madsen Morten , Linder Marie , Sulo Gerhard , Ghanima Waleed , Gislason Gunnar , Hohnloser Stefan H , Jenkins Aaron , Al-Khalili Faris , Tell Grethe S , Ehrenstein Vera 
Published: July 2021

Abstract

Aims
Using Scandinavian population-based registries, we assessed risk of stroke/systemic embolism (SE) and bleeding with non-vitamin K antagonist oral anticoagulants compared with warfarin in anticoagulation-naïve patients with atrial fibrillation (AF).

Methods and results
This historical cohort study included 219 545 AF patients [median age 74 years; 43% women; mean CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, stroke or transient ischaemic attack, vascular disease, age 65–74 years, sex category) score 3.3] initiating apixaban, dabigatran, rivaroxaban, or warfarin in Denmark, Norway, and Sweden (1 January 2013 to 31 December 2016). The primary endpoints were stroke/SE and major bleeding. The median follow-up times were 9.7 (3.9–21.5) months for stroke/SE and 9.6 (3.8–21.3) months for bleeding. Apixaban and warfarin initiators were older and had higher CHA2DS2-VASc scores compared with dabigatran and rivaroxaban initiators. After 1:1 propensity score matching, three cohorts were created: apixaban–warfarin (n = 111 162), dabigatran–warfarin (n = 56 856), and rivaroxaban–warfarin (n = 61 198). Adjusted hazard ratios (HRs) were estimated using a Cox regression. For stroke/SE, adjusted HRs against warfarin were 0.96 [95% confidence interval (CI): 0.87–1.06] for apixaban, 0.89 (95% CI: 0.80–1.00) for dabigatran, and 1.03 (95% CI: 0.92–1.14) for rivaroxaban. For major bleeding, the HRs against warfarin were 0.73 (95% CI: 0.67–0.78) for apixaban, 0.89 (95% CI: 0.82–0.97) for dabigatran, and 1.15 (95% CI: 1.07–1.25) for rivaroxaban. The results in the dabigatran cohort did not hold in all dose-defined subgroups.

Conclusion
In this large Scandinavian study among AF patients initiating oral anticoagulation, those initiating dabigatran, apixaban, and rivaroxaban had similar rates of stroke/SE to patients initiating warfarin. Rates of major bleeding were lower with apixaban and dabigatran and higher with rivaroxaban, each compared with warfarin.
Late Life in the Living Room: Room Décor, Functional Limitations, and Personality
Authors: Fingerman Karen L , Kim Yijung K , Zhang Shiyang , Ng Yee To , Birditt Kira S 
Published: July 2021

AbstractBackground and ObjectivesEnvironmental gerontology and environmental psychology theories address adaptations of living space for disability and individual preferences. This study combines these perspectives to examine how room décor (i.e., furnishings, design, decoration) corresponds with functional limitations and personality in late life.Research Design and MethodsOlder adults aged 65 and older (N = 286) completed interviews regarding living arrangements, functional limitations, personality, and depressive symptoms. Participants provided 3–4 photographs of the room where they spend the most time. Raters coded photographs for physical adaptations for functional limitations and 19 features of décor (e.g., crowding, color), fitting 3 categories: (a) newness, (b) comfort, and (c) cheerfulness. We estimated linear regression models to examine how functional limitations or personality are associated with room décor, and whether living arrangement moderates these links. We also assessed whether room décor moderates functional limitations or personality predicting depressive symptoms.ResultsFunctional limitations were associated with greater clutter and less brightness. Extraversion was associated with newness and cheerfulness (but not comfort), and conscientiousness with newness and comfort (but not cheerfulness). Openness was associated with more newness and cheerfulness for those who live alone. Moderation models revealed functional limitations were associated with fewer depressive symptoms if the room was more cluttered. Conscientiousness was negatively associated with depressive symptoms when the room was higher on newness or comfort.Discussion and ImplicationsFindings generally supported environmental psychology and environmental gerontology perspectives and suggest “goodness of fit” between functional abilities, personal desires, and room characteristics may contribute to benefits of aging in place.
Industrial policy against pandemics
Authors: Cherif Reda , Hasanov Fuad 
Published: July 2021

AbstractThe coronavirus disease 2019 (COVID-19) pandemic illustrated the inability of the market to meet the needed production scale and speed of essential medical products. The state should adopt a risk-based approach, allowing for experimentation with various technological solutions such as vaccines and tests, while ramping up their production. The intervention should resolve uncertainty, combine resources, coordinate technological choices, lift barriers to entry, ensure knowledge sharing, and support the value chain. The cost of this strategy is dwarfed by the economic fallout of a pandemic. Universal testing, an overlooked solution, is a key component of an infrastructure against future pandemics.
Female reproductive output and potential recruitment of three fished southern king crab stocks from the Southern Atlantic Ocean
Authors: Di Salvatore Pablo , Sacristán Hernán J , Florentín Olga , Varisco Martín , Lovrich Gustavo A 
Published: July 2021

Abstract
The female reproductive output and potential recruitment (PR) were studied in three Argentinean southern king crab (Lithodes santolla and Lithodes confundens) stocks: in the Beagle Channel (BC), under an artisanal fishery pressure since 1930; in the San Jorge Gulf (SJG), under 10-years industrial fishing exploitation; and off the Atlantic coast of Isla Grande de Tierra del Fuego (TDF), under current exploratory regime. After evaluating their reproductive parameters, we suggest that these fisheries pass through at least two detectable phases. The first phase, in the SJG stock, is sperm limitation evidenced by a high proportion of ovigerous females but a decreased female fecundity. A second phase, in the BC stock, shows a sustained low proportion of ovigerous females which were the largest females of this stock, along with a decreased relative abundance, which in lithodids are indicators of recruitment overfishing. Contrastingly, the TDF stock showed healthy population parameters before the opening of the exploratory fishery. The extremely low value of PR (2.6%) in the bc stock further reinforces that this stock is experiencing or has experienced recruitment overfishing, as a small proportion of the offspring would reach sexual maturity or achieve legal sizes.
Firm Size, Employment and Value Added in African Manufacturing Firms: Why Ghana Needs Its 1%
Authors: Teal Francis 
Published: July 2021

AbstractIn this paper, we use manufacturing firm census data to examine the size distribution of firms in Ghana for 1962, 1987 and 2003 and the distribution of employment and value added across the size distribution for 2003. We make four contributions to the literature on firm size in Africa. First, we compare the Tybout procedure, of matching employment shares to that implied by a Paretian distribution, to obtain the shape parameter from the Paretian distribution with a direct estimate from the firm size distribution. We show they differ. Our second contribution is to follow up on Tybout’s suggestion that a policy undistorted environment would produce a Paretian distribution and show that such a distribution can describe firm size, for both the 1987 and 2003 censuses, for firms with more than nine employees. The implication we draw is that processes of firm growth are quite different for firms above and below the nine employees’ threshold. Rather than there being a ‘missing middle’ of mid-sized firms, the data are better described as a ravine at nine employees, whereby the density of the distribution of firm size collapses at this point. Our third contribution is to show that the increasing dominance of the small, which has characterised firm growth in Ghana over this period, implies an increasing proportion of employment in the low productivity part of the size spectrum. Finally, we show that in 2003 while 95% of firms have less than ten employees, they produce only 14% of value added. At the other end of the size spectrum, less than 1% of the firms produced nearly 80% of value added.
Seeing Is Believing: Is Video Modality More Powerful in Spreading Fake News via Online Messaging Apps?
Authors: Sundar S Shyam , Molina Maria D , Cho Eugene 
Published: July 2021

Abstract
False rumors on WhatsApp, the world’s largest messaging app, have led to mob lynching in India and other countries. Doctored videos sent over the platform have elicited visceral responses among users, resulting in the wrongful death of innocent people. Would the responses have been so strong if the false news were circulated in text or audio? Is video modality the reason for such powerful effects? We explored this question by comparing reactions to three false stories prepared in either text-only, audio-only, or video formats, among rural and urban users in India. Our findings reveal that video is processed more superficially, and therefore users believe in it more readily and share it with others. Aside from advancing our theoretical understanding of modality effects in the context of mobile media, our findings also hold practical implications for design of modality-based flagging of fake news, and literacy campaigns to inoculate users against misinformation.