bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endemism-based butterfly conservation: insights from a study in Southern Western Ghats, India
Authors: Anto M. , Binoy C. F. , Anto Ignatious 
Published: May 2021

Abstract
Background
The Western Ghats, a biodiversity hotspot in India harbours a high percentage of endemic species due to its unique and diverse habitats. These species which cannot survive elsewhere due to their specialised habitat requirements are at high risk from climatic and anthropogenic disturbances. The butterfly fauna of the region although well documented has not been investigated intensively at local scales. In this study, we present information on species presence within 10 km × 10 km grid cells (n= 30; area=3000 km2) of 94 butterfly species in the Western Ghats region. The data on the species distribution within these grids which included three wildlife sanctuaries and four forest divisions was mapped. Indicator analysis was performed in R using multipatt function in indispecies package to determine species associated with sites/site combinations. The corrected weighted endemism indices of the study grids were estimated.

Results
The data collected over a 4-year period comprised of 393 records of 60 endemic species belonging to five families observed along 102 transects. Troides minos was the most widespread species occuring in 19 grids. Seventeen species indicative of sites and site combinations were obtained, of which Cirrochroa thais, Papilio paris tamilana, Papilio helenus daksha, Parthenos sylvia virens and Mycalesis patnia were significant. The highest corrected weighted endemism index was observed in grid 25 (14.44) followed by grids 24 (12.06) and 19 (11.86). Areas harbouring unique and range restricted species were Parambikulam WLS/TR: Kuthirakolpathy, Pupara, Kalyanathi, Top slip and Muthalakuzhy; Peechi-Vazhani WLS: Ayyapankadu; Thrissur FD: Chakkapara and Vellakarithadam; Nenmara FD: Karikutty, Pothumala and Nelliampathy estate; Vazhachal FD: Poringalkuthu dam, Meenchal and Vazhachal.

Conclusions
The study area which covers 2.14% of the Western Ghats hotspot harbours almost 63.82% of the region’s endemic butterfly species making this particular region crucial for butterfly conservation and management. Studying the phylogenetic endemism of the butterflies, identification of microrefugia and testing the mountain geobiodiversity hypothesis with respect to butterflies are the suggested approaches to be adopted for fine-tuning research and conservation of butterflies in this fragile hotspot.
Botulinum toxin type A for painful diabetic neuropathy: an open-label study
Authors: Helmy Shahinaz , Emara Tamer , Menem Amr Abdel 
Published: May 2021

Abstract
Background
A large proportion of painful diabetic neuropathy cases either do not respond or are intolerant to the currently available oral and physical therapies. There is encouraging evidence from a small number of studies that those patients can improve using botulinum toxin injection. The aim of the study was to evaluate the effect of intradermal injection of botulinum toxin type A on painful diabetic neuropathy. Eight adult patients with diabetic peripheral neuropathy (DPN), confirmed by nerve conduction studies, were refractory to a minimum of two neuropathic pain treatments for 6 months or more were recruited. All cases received intradermal injection of 48 units of botulinum toxins—type A in each foot in 6×4 distribution. Follow-up was done after 8 weeks using the Neuropathic Pain Scale (NPS), Pittsburgh Sleep Quality Index (PSQI), and Overall Disability Sum Scale (ODSS).

Results
After 8 weeks, there was a significant change in NPS from 55.8 (7.8) to 38.5 (8.1) (p value 0.007), also there was significant improvement in ODDS from 4 (IQR, 2.25-4.75) to 2.5 (IQR, 0.5-3) (p value 0.01). However, there was no significant change in PSQI.

Conclusion
Botulinum toxin type A injection is a promising treatment option in Egyptian DPN adults in this study.
In vitro study of protective effect of Pterocarpus erinaceus Poir. stem bark and Amaranthus spinosus L. root extracts on cataractogenesis and glomerulopathy
Authors: Atchou Kokou , Lawson-Evi Povi , Eklu-Gadegbeku Kwashie 
Published: May 2021

Abstract
Background
Cataracts and glomerulopathy are disabling complications of diabetes mellitus. The use of medicinal plants in the treatment of diabetes helps prevent or delay these complications. Pterocarpus erinaceus and Amaranthus spinosus are part of these medicinal plants used in traditional medicine to treat diabetes and its complications. The aim of this study was to evaluate in vitro the protective effect of the dried hydroethanolic extracts of the two plants against cataractogenesis and glomerulopathy induced by high glucose. Lenses and kidney fragments from Sprague–Dawley rats were cultured in artificial aqueous humor and in glomerular solution under high glucose, respectively. The extracts of the two plants at doses of 250 and 500 mg/kg bw were added to the culture medium and incubated for 72 h for the lenses and 96 h for the kidney fragments. Morphological and biochemical parameters were evaluated during the cultures.

Results
The lenses treated with extracts of both plants remained shiny and transparent in contrast to the opacity observed in toxic controls. The treatment by extract caused a significant (p < 0.001) decrease in malondialdehyde and a significant increase (p < 0.001) in glutathione and catalase levels in lenses and kidney fragments. The extracts also caused a significant increase (p < 0.0001) in glucose absorption in glomeruli and a decrease in tubular glucose reabsorption in kidney fragments. This led to a decrease in glucose in the incubation medium.

Conclusion
These findings showed that the dried hydroethanolic extract of P. erinaceus and A. spinosus can be used to reduce hyperglycemia effects by inhibiting oxidative stress pathways and then preventing or delaying the onset of cataracts and kidney failure in diabetes.
Measuring psychological pain: psychometric analysis of the Orbach and Mikulincer Mental Pain Scale
Authors: Casanova Madeline P. , Nelson Megan C. , Pickering Michael A. , Appleby Karen M. , Grindley Emma J. , Larkins Lindsay W. , Baker Russell T. 
Published: May 2021

AbstractBackgroundSuicide is a public health concern, with an estimated 1 million individuals dying each year worldwide. Individual psychological pain is believed to be a contributing motivating factor. Therefore, establishing a psychometrically sound tool to adequately measure psychological pain is important. The Orbach and Mikulincer Mental Pain Scale (OMMP) has been proposed; however, previous psychometric analysis on the OMMP has not yielded a consistent scale structure, and the internal consistency of the subscales has not met recommended values. Therefore, the primary purpose of this study was to assess the psychometric properties of the OMMP in a diverse sample.MethodsA confirmatory factor analysis (CFA) on the 9-factor, 44-item OMMP was conducted on the full sample (n= 1151). Because model fit indices were not met, an exploratory factor analysis (EFA) was conducted on a random subset of the data (n= 576) to identify a more parsimonious structure. The EFA structure was then tested in a covariance model in the remaining subset of participants (n= 575). Multigroup invariance testing was subsequently performed to examine psychometric properties of the refined scale.ResultsThe CFA of the original 9-factor, 44-item OMMP did not meet recommended model fit recommendations. The EFA analysis results revealed a 3-factor, 9-item scale (i.e., OMMP-9). The covariance model of the OMMP-9 indicated further refinement was necessary. Multigroup invariance testing conducted on the final 3-factor, 8-item scale (i.e., OMMP-8) across mental health diagnoses, sex, injury status, age, activity level, and athlete classification met all criteria for invariance.ConclusionsThe 9-factor, 44-item OMMP does not meet recommended measurement criteria and should not be recommended for use in research and clinical practice in its current form. The refined OMMP-8 may be a more viable option to use; however, more research should be completed prior to adoption.
A guide to reducing adverse outcomes in rabbit models of sciatic nerve injury
Authors: Orozco Elisabeth , Masuda Koichi , Shah Sameer B. 
Published: May 2021

Abstract
Background
Peripheral nerve damage can have debilitating consequences. Rabbit sciatic nerve transection models allow the effective evaluation of surgical repair strategies for large nerve gaps. Despite advantages in size, ease of handling, and functional utility, rabbits can suffer from a number of side effects that affect animal welfare and the quality of scientific inquiry. Such side-effects, which include pressure ulcers and traumatic damage to the foot, are primarily a consequence of insensitivity of the distal hindlimb following sciatic nerve injury. In this study, we present a number of methodologies for identifying, treating, and preventing unintended adverse effects in rabbit sciatic nerve injury models.

Results
First, we categorize pressure ulcers according to their severity and describe the deployment of a padded bandaging technique to enable ulcer healing. We also introduce a proactive bandaging approach to reduce the likelihood of pressure ulcer formation. Second, we define phenotypes that distinguish between foot injuries resulting from self-mutilation (autotomy) from those caused by incidental traumatic injury secondary to sensori-motor damage. Finally, we detail an effective strategy to reduce the usage of Elizabethan collars; through a gradual weaning protocol, their usefulness in preventing autotomy is retained, while their propensity to impede rabbit grooming and cause abrasion-injury to the neck region is minimized.

Conclusions
We suggest that application of these methods offer a practical and systematic approach to avoid adverse side effects associated with rabbit sciatic nerve damage, enabling improved animal welfare and scientific outcomes in a powerful nerve injury model.
The reasons women choose and stay in a geology major: a qualitative multi-case analysis
Authors: Gray Ron E. , Riche Alexis T. , Shinnick-Gordon Isabel J. , Sample James C. 
Published: May 2021

AbstractDespite earning half of all science and engineering undergraduate degrees between 2007 and 2016 in the USA, women were awarded only 39% of earth science degrees in the same time period. In order to better understand why women are both choosing and staying in geology programs, we conducted a multi-case study of nine current female undergraduate geology majors at a large public university in the USA within a department that is at gender parity among its undergraduate majors. The main data source was audio-recorded critical incident interviews of each participant. Data from the interviews were analyzed through an iterative coding process using codes adapted from previous studies that focused on factors both internal and external to the department. The students said that personal interests, influence by others outside of the department, and introductory classes attracted them to the geology program, but once declared, departmental factors such as relationship with faculty caused them to stay. We also found an emphasis on female role models, especially those teaching introductory courses. We believe this study offers important insights into the ways in which factors leading to recruitment and retention play out in the lived experiences of female geology majors.
Estimation of fractional cycle bias for GPS/BDS-2/Galileo based on international GNSS monitoring and assessment system observations using the uncombined PPP model
Authors: Wang Jin , Zhang Qin , Huang Guanwen 
Published: May 2021

AbstractThe Fractional Cycle Bias (FCB) product is crucial for the Ambiguity Resolution (AR) in Precise Point Positioning (PPP). Different from the traditional method using the ionospheric-free ambiguity which is formed by the Wide Lane (WL) and Narrow Lane (NL) combinations, the uncombined PPP model is flexible and effective to generate the FCB products. This study presents the FCB estimation method based on the multi-Global Navigation Satellite System (GNSS) precise satellite orbit and clock corrections from the international GNSS Monitoring and Assessment System (iGMAS) observations using the uncombined PPP model. The dual-frequency raw ambiguities are combined by the integer coefficients (4,− 3) and (1,− 1) to directly estimate the FCBs. The details of FCB estimation are described with the Global Positioning System (GPS), BeiDou-2 Navigation Satellite System (BDS-2) and Galileo Navigation Satellite System (Galileo). For the estimated FCBs, the Root Mean Squares (RMSs) of the posterior residuals are smaller than 0.1 cycles, which indicates a high consistency for the float ambiguities. The stability of the WL FCBs series is better than 0.02 cycles for the three GNSS systems, while the STandard Deviation (STD) of the NL FCBs for BDS-2 is larger than 0.139 cycles. The combined FCBs have better stability than the raw series. With the multi-GNSS FCB products, the PPP AR for GPS/BDS-2/Galileo is demonstrated using the raw observations. For hourly static positioning results, the performance of the PPP AR with the three-system observations is improved by 42.6%, but only 13.1% for kinematic positioning results. The results indicate that precise and reliable positioning can be achieved with the PPP AR of GPS/BDS-2/Galileo, supported by multi-GNSS satellite orbit, clock, and FCB products based on iGMAS.
Role of PET/CT in post-therapeutic assessment of bronchogenic carcinoma
Authors: Shaheen Amira Ayman , Mohammed Ahmed Mostafa , Elshimy Ahmed , Shalaby Mennatallah Hatem 
Published: May 2021

Abstract
Background
Lung cancer is the most common among all kinds of cancers. It still constitutes the leading cause of cancer-related deaths worldwide, even with major advancements in prevention and treatments available. More than 85% of the cases are of non-small cell lung cancer (NSCLC), while less than 15% are of small cell lung cancers (SCLCs).

Patients and methods
This is a prospective study of 20 patients confirmed histopathologically to have bronchogenic carcinoma, who came for assessment of therapeutic response. All patients underwent positron emission tomography/computed tomography (PET/CT) before and after therapy. Semiquantitative assessment was used to determine maximum standardized uptake value (SUVmax). Treatment response evaluation was assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST) criteria.

Results
Comparison of the pre- and post-treatment SUVmax in the responder and non-responder groups revealed that the post-treatment SUV was significantly lower than the baseline SUV in the responder group (P = 0.008). The responder post-treatment SUV and ∆ SUV were significantly lower than the non-responder values (P = 0.014 and 0.0004 respectively). The optimum threshold values of post-treatment SUV and ∆ SUV threshold defined by the receiver operating characteristic (ROC) curve analysis were ≤ 8 and ≤ −48.3 respectively. The sensitivity, specificity, PPV, NPV, and AUC of post-treatment SUV for predicting tumor response were 100%, 66.67%, 66.7%, 100%, and 0.833 respectively. The sensitivity, specificity, PPV, NPV, and AUC of ∆ SUV for predicting tumor response were 100%, 91.67%, 88.9%, 100%, and 0.979% respectively.

Conclusion
PET/CT proved itself as useful, efficient, and reliable tool in follow-up of lung cancer patients as it gives an early and accurate metabolic response assessment before any CT changes, leading to early modification of therapy or confirmation of its efficiency.
Multi-modality imaging of referred civilian combat-related injuries: a multi-center study in Egypt
Authors: Grace Marie Nader , Ibrahim Iman Mohamed Hamdy , Tadros Sally Fouad 
Published: May 2021

Abstract
Background
Several Arab countries as well as many parts of the world are currently involved in armed conflicts. Characterization and documentation of combat-related injury patterns and their impact on healthcare are a difficult challenge. However, it is crucial in planning and developing of strategies capable of addressing the demands of ill-equipped medical facilities. The aim of this study was to record the different patterns of combat-related injuries sustained by civilians transferred to Egyptian tertiary hospitals for further investigation and definite treatment after primary stabilization by an emergency trauma team in their countries.

Results
Metallic foreign bodies were detected in different body locations in 49.1% of patients, while bullets were identified in 12.3%. Injuries involving the musculoskeletal system of the extremities were the most frequent (77.2%), followed in descending order by maxillofacial injuries (41%), thoracic injuries (32.1%), cranial injuries (31%), abdominal injuries (21.1%), spinal injuries (8.8%), and vascular injuries (4.7%). Among the extremities injuries, bone fractures were the most common (68.5%).

Conclusion
Radiological assessment aids in the evaluation of patients coming from conflict zones pre- and postoperatively, to recognize the precise sites and types of their injuries, the number and location of metallic shrapnel or bullets, and detection of possible associated complications, which aid in accurate demonstration of the extent and patterns of combat-related injuries and guide the management plan.
Evaluation of Oncology Hospital at Home: Unplanned Health Care Utilization and Costs in the Huntsman at Home Real-World Trial
Authors: Mooney Kathi , Titchener Karen , Haaland Benjamin , Coombs Lorinda A. , O'Neil Brock , Nelson Richard , McPherson Jordan P. , Kirchhoff Anne C. , Beck Anna C. , Ward John H. 
Published: May 2021

PURPOSE Patients with cancer experience high rates of morbidity and unplanned health care utilization and may benefit from new models of care. We evaluated an adult oncology hospital at home program's rate of unplanned hospitalizations and health care costs and secondarily, emergency department (ED) use, length of hospital stays, and intensive care unit (ICU) admissions during the 30 days after enrollment. METHODS We conducted a prospective, nonrandomized, real-world cohort comparison of 367 hospitalized patients with cancer—169 patients consecutively admitted after hospital discharge to Huntsman at Home (HH), a hospital-at-home program, compared with 198 usual care patients concurrently identified at hospital discharge. All patients met clinical criteria for HH admission, but those in usual care lived outside the HH service area. Primary outcomes were the number of unplanned hospitalizations and costs during the 30 days after enrollment. Secondary outcomes included length of hospital stays, ICU admissions, and ED visits during the 30 days after enrollment. RESULTS Groups were comparable except that more women received HH care. In propensity-weighted analyses, the odds of unplanned hospitalizations was reduced in the HH group by 55% (odds ratio, 0.45, 95% CI, 0.29 to 0.70; P < .001) and health care costs were 47% lower (mean cost ratio, 0.53; 95% CI, 0.39 to 0.72; P < .001) over the 30-day period. Secondary outcomes also favored HH. Total hospital stay days were reduced by 1.1 days ( P = .004) and ED visits were reduced by 45% (odds ratio, 0.55; 95% CI, 0.33 to 0.92; P = .022). There was no evidence of a difference in ICU admissions ( P = .972). CONCLUSION This oncology hospital at home program shows initial promise as a model for oncology care that may lower unplanned health care utilization and health care costs.
Energy and wave-action flows underlying Rayleigh-Jeans thermalization of optical waves propagating in a multimode fiber
(a)
Authors: Baudin K. , Fusaro A. , Garnier J. , Berti N. , Krupa K. , Carusotto I. , Rica S. , Millot G. , Picozzi A. 
Published: May 2021

Abstract
The wave turbulence theory predicts that a conservative system of nonlinear waves can exhibit a process of condensation, which originates in the singularity of the Rayleigh-Jeans equilibrium distribution of classical waves. Considering light propagation in a multimode fiber, we show that light condensation is driven by an energy flow toward the higher-order modes, and a bi-directional redistribution of the wave-action (or power) to the fundamental mode and to higher-order modes. The analysis of the near-field intensity distribution provides experimental evidence of this mechanism. The kinetic equation also shows that the wave-action and energy flows can be inverted through a thermalization toward a negative temperature equilibrium state, in which the high-order modes are more populated than low-order modes. In addition, a Bogoliubov stability analysis reveals that the condensate state is stable.
Randomized Controlled Trial of Neurokinin 3 Receptor Antagonist Fezolinetant for Treatment of Polycystic Ovary Syndrome
Authors: Fraser Graeme L , Obermayer-Pietsch Barbara , Laven Joop , Griesinger Georg , Pintiaux Axelle , Timmerman Dirk , Fauser Bart C J M , Lademacher Christopher , Combalbert Jean , Hoveyda Hamid R , Ramael Steven 
Published: May 2021

Abstract

Context
Polycystic ovary syndrome (PCOS), a highly prevalent endocrine disorder characterized by hyperandrogenism, is the leading cause of anovulatory infertility.

Objective
This proof-of-concept study evaluated clinical efficacy and safety of the neurokinin 3 (NK3) receptor antagonist fezolinetant in PCOS.

Methods
This was a phase 2a, randomized, double-blind, placebo-controlled, multicenter study (EudraCT 2014-004409-34). The study was conducted at 5 European clinical centers. Women with PCOS participated in the study. Interventions included fezolinetant 60 or 180 mg/day or placebo for 12 weeks. The primary efficacy end point was change in total testosterone. Gonadotropins, ovarian hormones, safety and tolerability were also assessed.

Results
Seventy-three women were randomly assigned, and 64 participants completed the study. Adjusted mean (SE) changes in total testosterone from baseline to week 12 for fezolinetant 180 and 60 mg/day were −0.80 (0.13) and −0.39 (0.12) nmol/L vs −0.05 (0.10) nmol/L with placebo (P &lt; .001 and P &lt; .05, respectively). Adjusted mean (SE) changes from baseline in luteinizing hormone (LH) for fezolinetant 180 and 60 mg/d were −10.17 (1.28) and −8.21 (1.18) vs −3.16 (1.04) IU/L with placebo (P &lt; .001 and P = .002); corresponding changes in follicle-stimulating hormone (FSH) were −1.46 (0.32) and −0.92 (0.30) vs −0.57 (0.26) IU/L (P = .03 and P = .38), underpinning a dose-dependent decrease in the LH-to-FSH ratio vs placebo (P &lt; .001). Circulating levels of progesterone and estradiol did not change significantly vs placebo (P &gt; .10). Fezolinetant was well tolerated.

Conclusion
Fezolinetant had a sustained effect to suppress hyperandrogenism and reduce the LH-to-FSH ratio in women with PCOS.