bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socioeconomic inequalities in treatment and relative survival among patients with diffuse large B-cell lymphoma: a Hong Kong population-based study
Authors: Lee Shing Fung , Evens Andrew M. , Ng Andrea K. , Luque-Fernandez Miguel-Angel 
Published: September 2021

AbstractThe influence of socioeconomic status (SES) on access to standard chemotherapy and/or monoclonal antibody therapy, and associated secular trends, relative survival, and excess mortality, among diffuse large B-cell lymphoma (DLBCL) patients is not clear. We conducted a Hong Kong population-based cohort study and identified adult patients with histologically diagnosed DLBCL between 2000 and 2018. We examined the association of SES levels with the odds and the secular trends of receipt of chemotherapy and/or rituximab. Additionally, we estimated the long-term relative survival by SES utilizing Hong Kong life tables. Among 4017 patients with DLBCL, 2363 (58.8%) patients received both chemotherapy and rituximab and 740 (18.4%) patients received chemotherapy alone, while 1612 (40.1%) and 914 (22.8%) patients received no rituximab or chemotherapy, respectively. On multivariable analysis, low SES was associated with lesser use of chemotherapy (odd ratio [OR] 0.44; 95% CI 0.34–0.57) and rituximab (OR 0.41; 95% CI 0.32–0.52). The socioeconomic disparity for either treatment showed no secular trend of change. Additionally, patients with low SES showed increased excess mortality, with a hazard ratio of 2.34 (95% CI 1.67–3.28). Improving survival outcomes for patients with DLBCL requires provision of best available medical care and securing access to treatment regardless of patients’ SES.
Routinely collected antenatal data for longitudinal prediction of preeclampsia in nulliparous women: a population-based study
Authors: Sandström Anna , Snowden Jonathan M. , Bottai Matteo , Stephansson Olof , Wikström Anna-Karin 
Published: September 2021

AbstractThe objective was to evaluate the sequentially updated predictive capacity for preeclampsia during pregnancy, using multivariable longitudinal models including data from antenatal care. This population-based cohort study in the Stockholm-Gotland Counties, Sweden, included 58,899 pregnancies of nulliparous women 2008–2013. Prospectively collected data from each antenatal care visit was used, including maternal characteristics, reproductive and medical history, and repeated measurements of blood pressure, weight, symphysis-fundal height, proteinuria, hemoglobin and blood glucose levels. We used a shared-effects joint longitudinal model including all available information up until a given gestational length (week 24, 28, 32, 34 and 36), to update preeclampsia prediction sequentially. Outcome measures were prediction of preeclampsia, preeclampsia with delivery < 37, and preeclampsia with delivery ≥ 37 weeks’ gestation. The area under the curve (AUC) increased with gestational length. AUC for preeclampsia with delivery < 37 weeks’ gestation was 0.73 (95% CI 0.68–0.79) at week 24, and increased to 0.87 (95% CI 0.84–0.90) in week 34. For preeclampsia with delivery ≥ 37 weeks’ gestation, the AUC in week 24 was 0.65 (95% CI 0.63–0.68), but increased to 0.79 (95% CI 0.78–0.80) in week 36. The addition of routinely collected clinical measurements throughout pregnancy improve preeclampsia prediction and may be useful to individualize antenatal care.
Macrothrombocytopenia of Takenouchi-Kosaki syndrome is ameliorated by CDC42 specific- and lipidation inhibitors in MEG-01 cells
Authors: Daimon Etsuko , Shibukawa Yukinao , Thanasegaran Suganya , Yamazaki Natsuko , Okamoto Nobuhiko 
Published: September 2021

AbstractMacrothrombocytopenia is a common pathology of missense mutations in genes regulating actin dynamics. Takenouchi-Kosaki syndrome (TKS) harboring the c.191A > G, Tyr64Cys (Y64C) variant in Cdc42 exhibits a variety of clinical manifestations, including immunological and hematological anomalies. In the present study, we investigated the functional abnormalities of the Y64C mutant in HEK293 cells and elucidated the mechanism of macrothrombocytopenia, one of the symptoms of TKS patients, by monitoring the production of platelet-like particles (PLP) using MEG-01 cells. We found that the Y64C mutant was concentrated at the membrane compartment due to impaired binding to Rho-GDI and more active than the wild-type. The Y64C mutant also had lower association with its effectors Pak1/2 and N-WASP. Y64C mutant-expressing MEG-01 cells demonstrated short cytoplasmic protrusions with aberrant F-actin and microtubules, and reduced PLP production. This suggested that the Y64C mutant facilitates its activity and membrane localization, resulting in impaired F-actin dynamics for proplatelet extension, which is necessary for platelet production. Furthermore, such dysfunction was ameliorated by either suppression of Cdc42 activity or prenylation using chemical inhibitors. Our study may lead to pharmacological treatments for TKS patients.
Mathematical model for the tensile strength of the crimping assembly of aviation wiring harness end
Authors: Li Pin , Liu Gongping , Fan Junhua , Sun Jiyuan , Xiu Hang , Tian Chunlin 
Published: September 2021

AbstractIn this study, the relationship between the tensile strength and the indentation depth was studied by analysing the deformation mechanism of the crimping assembly of the aviation wiring harness end. Tensile strength tests were performed on samples of crimping assemblies with different indentation depths. The results showed that the experimental and theoretical values were in good agreement, verifying the validity of the established mathematical model for tensile strength. Based on this model, a reasonable design range for the indentation depth corresponding to the specific combination of contacts and strands was determined.
Deglacial bottom water warming intensified Arctic methane seepage in the NW Barents Sea
Authors: El bani Altuna Naima , Rasmussen Tine Lander , Ezat Mohamed Mahmoud , Vadakkepuliyambatta Sunil , Groeneveld Jeroen , Greaves Mervyn 
Published: September 2021

AbstractChanges in the Arctic climate-ocean system can rapidly impact carbon cycling and cryosphere. Methane release from the seafloor has been widespread in the Barents Sea since the last deglaciation, being closely linked to changes in pressure and bottom water temperature. Here, we present a post-glacial bottom water temperature record (18,000–0 years before present) based on Mg/Ca in benthic foraminifera from an area where methane seepage occurs and proximal to a former Arctic ice-sheet grounding zone. Coupled ice sheet-hydrate stability modeling shows that phases of extreme bottom water temperature up to 6 °C and associated with inflow of Atlantic Water repeatedly destabilized subsurface hydrates facilitating the release of greenhouse gasses from the seabed. Furthermore, these warming events played an important role in triggering multiple collapses of the marine-based Svalbard-Barents Sea Ice Sheet. Future warming of the Atlantic Water could lead to widespread disappearance of gas hydrates and melting of the remaining marine-terminating glaciers.
Ladder operators and coherent states for the Rosen–Morse system and its rational extensions
Authors: Garneau-Desroches S , Hussin V 
Published: September 2021

Abstract
Ladder operators for the hyperbolic Rosen–Morse (RMII) potential are realized using the shape invariance property appearing, in particular, using supersymmetric quantum mechanics. The extension of the ladder operators to a specific class of rational extensions of the RMII potential is presented and discussed. Coherent states are then constructed as almost eigenstates of the lowering operators. Some properties are analyzed and compared. The ladder operators and coherent states constructions presented are extended to the case of the trigonometric Rosen–Morse (RMI) potential using a point canonical transformation.
Visible Light Photocatalytic Degradation of Sunset Yellow Dye and Industrial Textile Wastewater Using Pd-BiFeO3 Composite
Authors: Jaffari Z H , Lam S M , Ng D Q , Sin J C 
Published: September 2021

Abstract
Herein, pristine BiFeO3 and Pd-incorporated BiFeO3 (Pd-BiFeO3) composite were synthesized using hydrothermal synthesis method. The physiochemical and optical properties of the synthesized materials were investigated using numerous techniques. The Pd-BiFeO3 composite significantly enhanced the photocatalytic degradation of sunset yellow (SSY) dye in comparison with the pristine BiFeO3 under visible light irradiation. The enhanced photoactivity was credited to the improved photogenerated charge carrier separation, which was in accordance with the photoelectrochemical measurements. Moreover, the Pd-BiFeO3 composite can be recycled for seven consecutive runs without sufficient loss of photocatalytic activity. Radical trapping studies suggested that the hydroxyl radical (•OH), hydrogen peroxide (H2O2) and hole (h+) were the key reactive oxidizing species. A possible photocatalytic enhancement mechanism of Pd-BiFeO3 composite was stated. Finally, for the first time, the Pd-BiFeO3 composite was also applied towards the effective degradation of industrial textile wastewater.
Detection of the Carbaryl in Wastewater by HPLC-DAD
Authors: Xiaona JI , Lin Fanglong , Ren Zhimin , Tian Xi , Zuo Yan , Bian Dejun 
Published: September 2021

Abstract
A method for determination of the carbaryl pesticide residue in wastewater by high performance liquid chromatography (HPLC). HPLC using Agilent ZORBAX SB-C18 column as a separate column; the use of volume ratio(55:45) of methanol: water as the mobile phase; the use of a diode array detector(DAD) detection at 268 nm at carbaryl residues; pretreatment of water samples using the extraction method is simple and feasible method of operation; laboratory water samples from wastewater, test results show: accuracy relative standard deviation(RSD) was 0.67%, and the recovery rates were in the range of 102 to 112%.
Research on Sustainable Development Path of Ecological Agriculture Industry in Beijing Suburbs—Taking Xibaidian Village, Daxingzhuang Town, Pinggu District as an Example
Authors: Wu Siqi , Wang Zhi , Tan Yarong 
Published: September 2021

Abstract
With the vigorous advancement of rural revitalization policies, industrial prosperity has put forward new requirements for the ecological agriculture industry. Not only requires the provision of higher quality agricultural products, but also promotes the adjustment of the agricultural industry structure. It is necessary to meet the continuous increase in farmers’ income and the people’s demand for a better life. In recent years, Beijing suburban agriculture has achieved good results in green production, rural energy and agricultural leisure construction. However, there are still problems such as being greatly affected by raw materials, low operating economic income, and insufficient technical equipment. In this paper, the three development models of eco agriculture in Xibaidian village are analyzed. Construct a sustainable development path for the ecological agriculture industry in the suburbs of Beijing from the development concept, development mechanism and new industrial formats. Promote diversification to build a rural complex in Beijing, and realize the harmonious unity of ecological protection and farmers’ income increase.
Techno-economic Analysis and Comparative Study for the Sustainability of Private Motor Vehicles in China
Authors: Lu Chuyue 
Published: September 2021

Abstract
This article discusses the life cycle energy consumption and cost of three new energy vehicles (NEVs) through life cycle analysis (LCA) and techno-economic analysis, and compares them with a conventional vehicle (CV). In ideal, average, and extreme scenarios, new energy vehicles are more sustainable than CV, especially in terms of greenhouse gas emissions, but are not as economical as CV. To be concise, electric vehicles have the best environmental sustainability, but the total cost is higher than CVs. The total cost of hybrid electric vehicles is slightly lower than conventional vehicles, but the environmental sustainability is poor.
Supervised machine learning applied to gas leak detection in air conditioner cooling system
Authors: Moreira S. F. , Shah V. , Varela M. L. R. , Monteiro A. C. , Putnik G. D. 
Published: September 2021

Abstract
This paper aims to present a concept test for an alternative refrigerant gas leak detection method, to be used in air conditioning manufacturing processes, in order to increase confidence in retaining products with gas leak in the factory, minimizing human interference in the test. To analyse the proposed solution, experimentation cycles were conducted, involving variables of industrial environment, product, and a thermographic camera with infrared technology, responsible for collecting the thermal image of the leak study area. Supervised machine learning method was used to train algorithms on temperature dataset to classify an area either as “Gas leakage” or “Normal”. The regression logistic algorithm had the best performance in the predictions, showing that it is possible to detect “Gas leakage” area in automatic decision-making in an industrial environmental.
Ketogenic dietary interventions in autosomal dominant polycystic kidney disease—a retrospective case series study: first insights into feasibility, safety and effects
Authors: Strubl Sebastian , Oehm Simon , Torres Jacob A , Grundmann Franziska , Haratani Jazmine , Decker Morgan , Vuong Sabrina , Kaur Bhandal Amrit , Methot Nils , Haynie-Cion Rhianna , Meyer Franziska , Siedek Florian , Korst Uwe , Müller Roman-Ulrich , Weimbs Thomas 
Published: September 2021

Abstract

Background
Our laboratory published the first evidence that nutritional ketosis, induced by a ketogenic diet (KD) or time-restricted diet (TRD), ameliorates disease progression in polycystic kidney disease (PKD) animal models. We reasoned that, due to their frequent use for numerous health benefits, some autosomal dominant PKD (ADPKD) patients may already have had experience with ketogenic dietary interventions (KDIs). This retrospective case series study is designed to collect the first real-life observations of ADPKD patients about safety, feasibility and possible benefits of KDIs in ADPKD as part of a translational project pipeline.

Methods
Patients with ADPKD who had already used KDIs were recruited to retrospectively collect observational and medical data about beneficial or adverse effects and the feasibility and safety of KDIs in questionnaire-based interviews.

Results
A total of 131 ADPKD patients took part in this study. About 74 executed a KD and 52 a TRD for 6 months on average. A total of 86% of participants reported that KDIs had improved their overall health, 67% described improvements in ADPKD-associated health issues, 90% observed significant weight loss, 64% of participants with hypertension reported improvements in blood pressure, 66% noticed adverse effects that are frequently observed with KDIs, 22 participants reported safety concerns like hyperlipidemia, 45 participants reported slight improvements in estimated glomerular filtration rate and 92% experienced KDIs as feasible while 53% reported breaks during their diet.

Conclusions
Our preliminary data indicate that KDIs may be safe, feasible and potentially beneficial for ADPKD patients, highlighting that prospective clinical trials are warranted to confirm these results in a controlled setting and elucidate the impact of KDIs specifically on kidney function and cyst progression.
Matrix metalloproteinase-2 on activated platelets triggers endothelial PAR-1 initiating atherosclerosis
Authors: Momi Stefania , Falcinelli Emanuela , Petito Eleonora , Ciarrocca Taranta Giulia , Ossoli Alice , Gresele Paolo 
Published: September 2021

Abstract

Aims
Platelets participate in atherogenesis with mechanisms not yet fully clarified. Vascular wall MMP-2 is involved in the arterial remodelling accompanying atherosclerosis. Platelets contain and release MMP-2 but no informations are available on its role in atherosclerotic lesion formation.

Methods and results
We generated double knockout mice lacking the LDL receptor and MMP-2 only in circulating blood cells showing that they develop significantly lesser femoral intima thickening after photochemical-induced arterial damage and atherosclerotic lesions in the aorta, measured by the en face method, after 4 months of atherogenic diet. Moreover, repeated transfusions of autologous-activated platelets in LDLR−/− mice on atherogenic diet significantly enhanced the extension of aortic atherosclerotic lesions while transfusion of activated platelets from MMP-2−/− mice did not. In vitro coincubation studies showed that platelet-derived MMP-2 plays a pivotal role in the development and progression of atherosclerosis through a complex cross-talk between activated platelets, monocyte/macrophages, and endothelial cells. Translational studies in patients with CAD and chronic HIV infection showed that platelet surface expression of MMP-2 highly significantly correlated with the degree of carotid artery stenosis.

Conclusion
We show a previously unknown mechanism of the pathway through which platelets expressing MMP-2 trigger the initial phases of atherosclerosis and provide a mechanism showing that they activate endothelial PAR-1 triggering endothelial p38MAPK signalling and the expression of adhesion molecules. The development of drugs blocking selectively platelet MMP-2 or its expression may represent a new approach to the prevention of atherosclerosis.
Pipeline for generating stable large genomic deletions in zebrafish, from small domains to whole gene excisions
Authors: Tromp Alisha , Robinson Kate , Hall Thomas E , Mowry Bryan , Giacomotto Jean 
Published: September 2021

Abstract
Here we describe a short feasibility study and methodological framework for the production of stable, CRISPR/Cas9-based, large genomic deletions in zebrafish, ranging from several base pairs (bp) to hundreds of kilobases (kb). Using a cocktail of four single guide RNAs (sgRNAs) targeting a single genomic region mixed with a marker-sgRNA against the pigmentation gene tyrosinase, we demonstrate that one can easily and accurately excise genomic regions such as promoters, protein domains, specific exons, or whole genes. We exemplify this technique with a complex gene family, neurexins, composed of three duplicated genes with multiple promoters and intricate splicing processes leading to thousands of isoforms. We precisely deleted small regions such as their transmembrane domains (150 bp deletion in average) to their entire genomic locus (300 kb deletion for nrxn1a for instance). We find that both the concentration and ratio of Cas9/sgRNAs are critical for the successful generation of these large deletions and, interestingly, that in our study, their transmission frequency does not seem to decrease with increasing distance between sgRNA target sites. Considering the growing reports and debate about genetically compensated small indel mutants, the use of large-deletion approaches is likely to be widely adopted in studies of gene function. This strategy will also be key to the study of non-coding genomic regions. Note that we are also describing here a custom method to produce the sgRNAs, which proved to be faster and more robust than the ones traditionally used in the community to date.
Changes in the Hierarchy of Functional Impairment From Middle Age to Older Age
Authors: Brown Rebecca T , Diaz-Ramirez L Grisell , Boscardin W John , Cappola Anne R , Lee Sei J , Steinman Michael A 
Published: September 2021

Abstract

Background
Understanding the hierarchy of functional impairment in older adults has helped illuminate mechanisms of impairment and inform interventions, but little is known about whether hierarchies vary by age. We compared the pattern of new-onset impairments in activities of daily living (ADLs) and instrumental ADLs (IADLs) from middle age through older age.

Methods
We conducted a cohort study using nationally representative data from 32 486 individuals enrolled in the Health and Retirement Study. The outcomes were new-onset impairment in each ADL and IADL, defined as self-reported difficulty performing each task, assessed yearly for 9 years. We used multistate models and competing risks survival analysis to estimate the cumulative incidence of impairment in each task by age group (ages 50–64, 65–74, 75–84, and 85 or older).

Results
The pattern of incident ADL impairments differed by age group. Among individuals ages 50–64 and 65–74 who were independent at baseline, over 9 years’ follow-up, difficulties dressing and transferring were the most common impairments to develop. In individuals ages 75–84 and 85 or older who were independent at baseline, difficulties bathing, dressing, and walking were most common. For IADLs, the pattern of impairments was similar across age groups; difficulty shopping was most common followed by difficulty managing money and preparing meals. Complementary analyses demonstrated a similar pattern.

Conclusions
These findings suggest that the hierarchy of ADL impairment differs by age. These findings have implications for the development of age-specific interventions to prevent or delay functional impairment.
Frequency filter for elastic bending waves: Poincaré map method and experiment
Authors: Torres-Guzmán J C , Arreola-Lucas A , Quintana-Moreno M , Zamora-Romero N , Flores-Olmedo E , Báez G , Méndez-Sánchez R A 
Published: September 2021

Abstract
In this work, the Poincaré map numerical method was successfully developed to solve the fourth-order differential equation that describes the flexural vibrations of a beam, within the Timoshenko beam theory. The Euler-Bernoulli continuity conditions were considered, which are valid for frequencies smaller than the critical frequency. As an example, this method was used to design a complex elastic structure, characterized by a flexural frequency spectrum with a broad band gap. Such structure consists of two coupled phononic crystals, which were designed with filling factor values in such a way that in their bending frequency spectra, an allowed band of the first part, overlaps with a band gap of the second one and vice versa. The resulting composed system has a much wider effective gap than its original components, between 4 and 10.5 kHz. This system works as an elastic bending wave filter. Finally, these three structured elastic systems were constructed, and characterized by the acoustic resonance spectroscopy technique. The natural flexural frequencies as well as the corresponding wave amplitudes of each structured beam were measured. The experimental measurements show excellent agreement with the numerical simulation.
BioSeq-BLM: a platform for analyzing DNA, RNA and protein sequences based on biological language models
Authors: Li Hong-Liang , Pang Yi-He , Liu Bin 
Published: September 2021

AbstractIn order to uncover the meanings of ‘book of life’, 155 different biological language models (BLMs) for DNA, RNA and protein sequence analysis are discussed in this study, which are able to extract the linguistic properties of ‘book of life’. We also extend the BLMs into a system called BioSeq-BLM for automatically representing and analyzing the sequence data. Experimental results show that the predictors generated by BioSeq-BLM achieve comparable or even obviously better performance than the exiting state-of-the-art predictors published in literatures, indicating that BioSeq-BLM will provide new approaches for biological sequence analysis based on natural language processing technologies, and contribute to the development of this very important field. In order to help the readers to use BioSeq-BLM for their own experiments, the corresponding web server and stand-alone package are established and released, which can be freely accessed at http://bliulab.net/BioSeq-BLM/.