bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of C1-INH therapy in angiotensin converting enzyme inhibitor induced angioedema
Authors: Kovaltchouk Uliana , Zhang Boyang , Jain Vipul , Kalicinsky Chrystyna 
Published: February 2021

Abstract
Introduction
Angiotensin Converting Enzyme Inhibitors (ACEI) are a common cause of Emergency Room presentation for angioedema. Although no treatment guidelines exist, C1 esterase inhibitor concentrate (C1-INH) is used on an off label basis for management of ACEI acquired angioedema (ACEI AAE).

Objective
To evaluate the efficacy of C1-INH in management of ACEI AAE at our local centers.

Results
Nine patients, from 3 academic sites, were identified through Allergy Service consultation data and records from Diagnostic Services Manitoba, Canada from 2010–2020. The majority of the patients (n = 8/9) required endotracheal intubation prior to the initiation of C1-INH. Overall, approximately 56% of patients (n = 5/9) had resolution of angioedema ranging between 12 and 17 h, with a median time of 13.5 h, and no recurrence after the administration of C1-INH concentrate. One patient had transient symptom resolution in 14 h, however, recurrence of angioedema required re-intubation. The remainder of patients (n = 4/9), had resolution of angioedema between 22 and 72 h, with a median time of 33.75 h.

Conclusion
Our findings demonstrate continued ambivalence of the efficacy and role of C1-INH concentrate in the treatment of ACEI AAE, secondary to multiple uncontrolled confounding factors. Further research into characterizing a subgroup of intubated patients in our study that responded to C1-INH concentrate needs to be completed.
Primary breast tuberculosis: imaging findings of a rare disease
Authors: Baykan Ali H. , Sayiner Hakan S. , Inan Ibrahim , Aydin Elcin , Erturk Sukru M. 
Published: February 2021

AbstractBreast tuberculosis is a rare form of extrapulmonary tuberculosis which tends to affect females of reproductive age, and is much rarer in males, postmenopausal women, and pre-pubescent girls. It is difficult to diagnose because it can mimic benign conditions such as a fibroadenoma, as well as malignant diseases like a carcinoma. It is also particularly difficult to distinguish breast tuberculosis from granulomatous mastitis, so other possible diagnoses should be ruled out first. The diagnosis of breast tuberculosis has three essential pillars: clinical examination, radiological evaluations, and histopathological sampling. Radiological evaluations are not only critical in diagnosis but are also important in the planning of the treatment and during the follow-up. This paper aims to review the imaging findings and the differential diagnosis of breast tuberculosis.
Vancomycin induced cardiac arrest: a case report
Authors: Khakurel Sharad , Rawal Sangam 
Published: February 2021

AbstractBackgroundRapid intravenous administration of vancomycin may manifest with histaminergic responses with clinical features ranging from mild rashes, pruritus and even shock. This case reports of a child, who was accidentally given intravenous vancomycin within minutes and hadacardiac arrest.Case presentationA 9-year-old Asian girl who was scheduled for a limb salvage surgery, received vancomycin preoperatively. As a result of rapid infusion of the drug, the patient developed flushing, pruritus and had respiratory distress with hypotension leading to asystole. However, prompt detection and immediate cardiopulmonary resuscitation revived the patient in time following which sound recovery ensued. We recognised inadvertent brisk infusion of vancomycin as the culprit with strong suspicion of Red Man Syndrome.ConclusionRed Man Syndrome, though rarely encountered, can always be life threatening. With a surge in the use of vancomycin, adverse effects associated with its use also rises. So a comprehensive knowledge regarding its rationale use, adverse effects and its prompt management in personnel prescribing it, can be life saving.
SGLT2 inhibition alleviated hyperglycemia, glucose intolerance, and dumping syndrome-like symptoms in a patient with glycogen storage disease type Ia: a case report
Authors: Katayama Daisuke , Baba Hiroo , Kuwabara Takashige , Kido Jun , Mitsubuchi Hiroshi , Matsumoto Shirou , Nakamura Kimitoshi 
Published: February 2021

Abstract
Background
Glycogen storage disease (GSD) type Ia is a glycogenesis disorder with long-term complications such as hepatomegaly and renal dysfunction and is caused by congenital loss of glucose-6-phosphatase (G6Pase) expression. G6Pase is essential for the final step of gluconeogenesis and glycogenolysis, and its deficiency causes clinical hypoglycemia in the fasting state during infancy. Contrastingly, patients also show blood glucose trends and glucose intolerance similar to those in type II diabetes. Owing to the contrasting presentation of hypoglycemia with glucose intolerance, glucose control in patients remains a challenge, requiring management of both fasting hypoglycemia and post-prandial hyperglycemia.

Case presentation
The patient was a 45-year old Asian (Japanese) woman who showed disease onset at 3 years of age, when hypoglycemia and hepatomegaly were observed, and GDS type Ia was diagnosed by the lack of G6Pase activity. Over the past 45 years, she presented hyperglycemia and dumping syndrome like symptoms (a feeling of fullness, even after eating just a small amount, abdominal cramping, nausea, sweating, flushing, or light-headedness and rapid heartbeat) at 2 hours after food intake. Her liver and kidney dysfunction also worsened over time. Treatment with exercise combined with a sodium-glucose co-transporter 2 inhibitor and an alpha glucosidase inhibitor alleviated her glucose intolerance and dumping syndrome-like symptoms, without increasing hypoglycemic events.

Conclusion
This case suggests SGLT2 inhibitor as a promising candidate for treating glucose intolerance in GSD type Ia without worsening of hypoglycemia.
Mesenchymal stem cells modified by FGF21 and GLP1 ameliorate lipid metabolism while reducing blood glucose in type 2 diabetic mice
Authors: Xue Binghua , Xiao Xiuxiao , Yu Tingting , Xiao Xinhua , Xie Jing , Ji Qiuhe , Wang Li , Na Tao , Meng Shufang , Qian Lingjia , Duan Haifeng 
Published: February 2021

Abstract
Objective
The purpose of this study was to investigate the therapeutic effects of genetically modified mesenchymal stem cells (MSCs) in the treatment of type 2 diabetes mellitus (T2DM) in order to identify a new method for treating diabetes that differs from traditional medicine and to provide a new means by which to fundamentally improve or treat diabetes.

Methods
MSCs derived from adipose tissue were modified to overexpress FGF21 and GLP1, which was achieved through lentiviral particle transduction. The cells were transplanted into BKS.Cg-Dock7m+/+Leprdb/Nju mice (T2DM mouse model). Injections of physiological saline (0.1 mL) and liraglutide (0.5 mg/kg) were used as negative and positive controls, respectively. ELISA or Western blotting was used for protein analysis, and quantitative real-time PCR was used for gene expression analysis.

Results
Genetic modification had no effects on the morphology, differentiation ability, or immunophenotype of MSCs. Moreover, MSC-FGF21+GLP1 cells exhibited significantly increased secretion of FGF21 and GLP1. In the T2DM mouse model, the transplantation of MSC-FGF21+GLP1 cells ameliorated the changes in blood glucose and weight, promoted the secretion of insulin, enhanced the recovery of liver structures, and improved the profiles of lipids. Moreover, FGF21 and GLP1 exerted synergistic effects in the regulation of glucolipid metabolism by controlling the expression of insulin, srebp1, and srebp2.

Conclusion
Stem cell treatment based on MSCs modified to overexpress the FGF21 and GLP1 genes is an effective approach for the treatment of T2DM.
3D skin models in domestic animals
Authors: Souci Laurent , Denesvre Caroline 
Published: February 2021

AbstractThe skin is a passive and active barrier which protects the body from the environment. Its health is essential for the accomplishment of this role. Since several decades, the skin has aroused a strong interest in various fields (for e.g. cell biology, medicine, toxicology, cosmetology, and pharmacology). In contrast to other organs, 3D models were mostly and directly elaborated in humans due to its architectural simplicity and easy accessibility. The development of these models benefited from the societal pressure to reduce animal experiments. In this review, we first describe human and mouse skin structure and the major differences with other mammals and birds. Next, we describe the different 3D human skin models and their main applications. Finally, we review the available models for domestic animals and discuss the current and potential applications.
Phages from Ganges River curtail in vitro biofilms and planktonic growth of drug resistant Klebsiella pneumoniae in a zebrafish infection model
Authors: Sundaramoorthy Niranjana Sri , Thothathri Subramaniam , Bhaskaran Muthumeenakshi , GaneshPrasad ArunKumar , Nagarajan Saisubramanian 
Published: February 2021

AbstractBacteriophages are a promising alternative for curtailing infections caused by multi drug resistant (MDR) bacteria. The objective of the present study is to evaluate phage populations from water bodies to inhibit planktonic and biofilm mode of growth of drug resistant Klebsiella pneumoniae in vitro and curtail planktonic growth in vivo in a zebrafish model. Phage specific to K. pneumoniae (MTCC 432) was isolated from Ganges River (designated as KpG). One-step growth curve, in vitro time kill curve study and in vivo infection model were performed to evaluate the ability of phage to curtail planktonic growth. Crystal violet assay and colony biofilm assay were performed to determine the action of phages on biofilms. KpG phages had a greater burst size, better bactericidal potential and enhanced inhibitory effect against biofilms formed at liquid air and solid air interfaces. In vitro time kill assay showed a 3 log decline and a 6 log decline in K. pneumoniae colony counts, when phages were administered individually and in combination with streptomycin, respectively. In vivo injection of KpG phages revealed that it did not pose any toxicity to zebrafish as evidenced by liver/brain enzyme profiles and by histopathological analysis. The muscle tissue of zebrafish, infected with K. pneumoniae and treated with KpG phages alone and in combination with streptomycin showed a significant 77.7% and 97.2% decline in CFU/ml, respectively, relative to untreated control. Our study reveals that KpG phages has the potential to curtail plantonic and biofilm mode of growth in higher animal models.
Novel filter bank-based cooperative spectrum sensing under practical challenges for beyond 5G cognitive radios
Authors: Dikmese Sener , Lamichhane Kishor , Renfors Markku 
Published: February 2021

AbstractCognitive radio (CR) technology with dynamic spectrum management capabilities is widely advocated for utilizing effectively the unused spectrum resources. The main idea behind CR technology is to trigger secondary communications to utilize the unused spectral resources. However, CR technology heavily relies on spectrum sensing techniques which are applied to estimate the presence of primary user (PU) signals. This paper firstly focuses on novel analysis filter bank (AFB) and FFT-based cooperative spectrum sensing (CSS) techniques as conceptually and computationally simplified CSS methods based on subband energies to detect the spectral holes in the interesting part of the radio spectrum. To counteract the practical wireless channel effects, collaborative subband-based approaches of PU signal sensing are studied. CSS has the capability to relax the problems of both hidden nodes and fading multipath channels. FFT- and AFB-based receiver side sensing methods are applied for OFDM waveform and filter bank-based multicarrier (FBMC) waveform, respectively, the latter one as a candidate beyond-OFDM/beyond-5G scheme. Subband energies are then applied for enhanced energy detection (ED)-based CSS methods that are proposed in the context of wideband, multimode sensing. Our first case study focuses on sensing potential spectral gaps close to relatively strong primary users, considering also the effects of spectral regrowth due to power amplifier nonlinearities. The study shows that AFB-based CSS with FBMC waveform is able to improve the performance significantly. Our second case study considers a novel maximum–minimum energy detector (Max–Min ED)-based CSS. The proposed method is expected to effectively overcome the issue of noise uncertainty (NU) with remarkably lower implementation complexity compared to the existing methods. The developed algorithm with reduced complexity, enhanced detection performance, and improved reliability is presented as an attractive solution to counteract the practical wireless channel effects under low SNR. Closed-form analytic expressions are derived for the threshold and false alarm and detection probabilities considering frequency selective scenarios under NU. The validity of the novel expressions is justified through comparisons with respective results from computer simulations.
On some Hermite–Hadamard inequalities involving k-fractional operators
Authors: Wu Shanhe , Iqbal Sajid , Aamir Muhammad , Samraiz Muhammad , Younus Awais 
Published: February 2021

AbstractThe main objective of this paper is to establish some new Hermite–Hadamard type inequalities involving k-Riemann–Liouville fractional integrals. Using the convexity of differentiable functions some related inequalities have been proved, which have deep connection with some known results. At the end, some applications of the obtained results in error estimations of quadrature formulas are also considered.
A dynamic optimal control model for COVID-19 and cholera co-infection in Yemen
Authors: Hezam Ibrahim M. , Foul Abdelaziz , Alrasheedi Adel 
Published: February 2021

AbstractIn this work, we propose a new dynamic mathematical model framework governed by a system of differential equations that integrates both COVID-19 and cholera outbreaks. The estimations of the model parameters are based on the outbreaks of COVID-19 and cholera in Yemen from January 1, 2020 to May 30, 2020. Moreover, we present an optimal control model for minimizing both the number of infected people and the cost associated with each control. Four preventive measures are to be taken to control the outbreaks: social distancing, lockdown, the number of tests, and the number of chlorine water tablets (CWTs). Under the current conditions and resources available in Yemen, various policies are simulated to evaluate the optimal policy. The results obtained confirm that the policy of providing resources for the distribution of CWTs, providing sufficient resources for testing with an average social distancing, and quarantining of infected individuals has significant effects on flattening the epidemic curves.
Influence of Shear Span-to-Effective Depth Ratio on Behavior of High-Strength Reinforced Concrete Beams
Authors: Arowojolu Olaniyi , Ibrahim Ahmed , Almakrab Abdullah , Saras Nicholas , Nielsen Richard 
Published: February 2021

AbstractThe shear span-to-effective depth ratio (a/d) is one of the factors governing the shear behavior of reinforced concrete (RC) beams, with or without shear reinforcement. In high-strength concrete (HSC), cracks may propagate between the aggregate particles and result in a brittle failure which is against the philosophy of most design guidelines. The experimental results of six HSC beams, with and without shear reinforcement, tested under four-point bending with a/d ranged from 2.0 to 3.0 are presented and compared with different model equations in design codes. The a/d ratio has higher influence on the shear strength of reinforced HSC beams without shear reinforcement than beams with shear reinforcement. Most of the shear resistance prediction models underestimate the concrete shear strength of the beams but overpredict shear resistance of beams with shear reinforcement. However, the fib Model code 2010 accurately predicted the shear resistance for all the beams within an appropriate level of approximation (LoA).
Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial
Authors: Crocchiolo Roberto , Cesana Clara , Girgenti Debora , Bertani Giambattista , Barba Claudia , Liga Giuseppa , Ferri Ursula , Crucitti Lara , Grillo Giovanni , Rossini Silvano , Cairoli Roberto 
Published: February 2021

AbstractThe aim of the present study was to evaluate the circulating T regulatory cells (Tregs) in patients undergoing extracorporeal photopheresis (ECP) for the prevention of chronic graft-versus-host disease (GvHD) and to search for any correlation between Tregs counts and chronic GvHD occurrence. Among n = 12 patients with complete longitudinal data, the median cumulative values of absolute peripheral Tregs counts were 21.64 and 63.49 cells/µL for patients who developed chronic GvHD and those who did not develop it, respectively (p = 0.05). The analysis of the median absolute counts of peripheral HLA-DR + Tregs provided similar results, showing that 20% (1 out of 5) and 100% (7 out of 7) of patients with HLA-DR + Tregs values of > 5 cells/µL were in the GvHD and non-GvHD groups, respectively (p = 0.01). In conclusion, the present results support the involvement of Tregs in the prevention of chronic GvHD in patients receiving ECP and suggest Tregs count as a potential biomarker of ECP effectiveness. Future strategies are needed to enhance Tregs expansion and/or activity in conjunction with ECP for an effective chronic GvHD prevention.
MR imaging features of pancreatic schwannoma: a Chinese case series and a systematic review of 25 cases
Authors: Shi Zhenshan , Cao Dairong , Zhuang Qian , You Ruixiong , Li Xiumei , Li Zhongmin , Li Yueming , Huang Xinming 
Published: February 2021

Abstract
Background
There is a paucity of existing literature centering on the magnetic resonance (MR) imaging features of pancreatic schwannomas, due to the neoplasm’s nonspecific presentation and its rarity. We aimed to identify the characteristic imaging features of pancreatic schwannoma.

Methods
This retrospective search was conducted for histologically confirmed pancreatic schwannoma in multi-institutional database of pathology. Abdominal magnetic resonance imaging (MRI) was performed before histologic examination and their MR imaging studies were independently reviewed. The search yielded six adults (mean age, 46 years) with a definitive histologic postoperative diagnosis of single pancreatic schwannoma each. Additionally, a comprehensive English and Chinese literature review for pancreatic schwannoma and reported MR-imaging findings since 1961 was also conducted. MR imaging features of those cases in the literature were analyzed, summarized and compared with our case series.

Results
This rare entity appeared to be a well-circumscribed, exophytic, oval or round pancreatic mass with a mean greatest diameter of 3.7 cm. Five schwannomas were located in the pancreatic head-neck and one in the pancreatic tail. On MRI, all cases appeared hypointense on T1-weighted images, inhomogeneous hyperintense on T2-weighted images, and hyperintense on diffusion-weighted images. The mean apparent diffusion coefficient (ADC) values of pancreatic schwannoma were 1.11 ± 0.29 × 10− 3 mm2/s and significantly lower than the surrounding pancreas. The lesion-to-pancreas signal intensity ratio (SIR) at unenhanced T1-weighted images was 0.53 ± 0.07. On dynamic contrast-enhanced MRI, most of the lesions (67%, 4/6) showed homogeneously iso- or hypointense on arterial and portal venous phases, and hyperenhancement on delayed phase compared with the surrounding pancreas. In our analysis of the time intensity curves, all cases exhibited a gradual enhancement pattern.

Conclusions
A well-circumscribed mass displaying inhomogeneous hyperintensity on T2, marked hypointensity on T1, hyperintensity on DWI, and with early slight enhancement at arterial phase and progressive enhancement at portal venous and delayed phase, may suggest the diagnosis of pancreatic schwannoma.
The microbial world in a changing environment
Authors: Vicuña Rafael , González Bernardo 
Published: February 2021

Abstract
Background
In this article we would like to touch on the key role played by the microbiota in the maintenance of a sustainable environment in the entire planet. For obvious reasons, this article does not intend to review thoroughly this extremely complex topic, but rather to focus on the main threats that this natural scenario is presently facing.

Methods
Recent literature survey.

Results
Despite the relevance of microorganisms have in our planet, the effects of climate change on microbial communities have been scarcely and not systematically addressed in literature. Although the role of microorganisms in emissions of greenhouse gases has received some attention, there are several microbial processes that are affected by climate change with consequences that are presently under assessment. Among them, host-pathogen interactions, the microbiome of built environment, or relations among plants and beneficial microbes.

Conclusions
Further research is required to advance in knowledge of the effect of climate change on microbial communities. One of the main targets should be a complete evaluation of the global microbial functional diversity and the design of new strategies to cope with limitations in methods to grow microorganisms in the laboratory. These efforts should contribute to raise a general public awareness on the major role played by the microbiota on the various Earth ecosystems.
Intravitreal sirolimus for persistent, exudative age-related macular degeneration: a Pilot Study
Authors: Minturn Robert J. , Bracha Peter , Klein Margaret J. , Chhablani Jay , Harless Ashley M. , Maturi Raj K. 
Published: February 2021

Abstract
Background and objective
To evaluate the safety and efficacy of intravitreal sirolimus for persistent, exudative age-related macular degeneration (AMD).

Methods
This institutional review board approved, registered (NCT02357342), prospective, subject-masked, single center, randomized controlled trial in subjects with persistent, exudative Age-related macular degeneration compared intravitreal sirolimus monotherapy (every 2 months) versus monthly anti-vascular endothelial growth factor (VEGF) over six months.

Results
20 subjects were randomized to each arm of the trial. Upon completion of the trial 20 patients were analyzed in the control (anti-vascular endothelial growth factor) group and 17 patients were analyzed in the treatment (sirolimus) group. On average, subjects had 33 previous anti-VEGF injections prior to entry. The primary end-point, mean central subfield thickness (CST), increased by 20 µm in the anti-vascular endothelial growth factor group and decreased by 40 µm in the sirolimus group (p = 0.03). Visual acuity outcomes were similar between groups. Serious ocular adverse events in the sirolimus group included one subject each with anterior uveitis, central retinal artery occlusion and subretinal hemorrhage.

Conclusion
Monotherapy with intravitreal sirolimus for subjects with persistent, exudative age-related macular degeneration appears to have a limited positive anatomic benefit. The presence of adverse events in the experimental group merits further evaluation, potentially as an adjuvant therapy.
Trial registration This trial was registered with the clinicaltrials.gov, NCT02357342, and was approved by the institutional review board at Advarra. Funding was provided by an investigator-initiated grant from Santen. Santen played no role in the design or implementation of this study.