bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involvement of the extracellular matrix proteins periostin and tenascin C in nasal polyp remodeling by regulating the expression of MMPs
Authors: Du Kun , Wang Min , Zhang Nan , Yu Pei , Wang Ping , Li Ying , Wang Xiangdong , Zhang Luo , Bachert Claus 
Published: September 2021

AbstractBackgroundTissue remodeling caused by increased MMPs is involved in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). We previously found higher levels of periostin and tenascin C in CRSwNPs, but whether they are associated with the dysregulation of MMPs is unknown. Therefore, the present study aimed to investigate the regulatory roles of these two ECM proteins in the expression of MMPs in nasal polyps.MethodsThe concentrations of MMP‐2, MMP‐3, MMP‐7, MMP‐8, MMP‐9, MMP‐12, MMP‐13, TIMP‐1, TIMP‐2, TIMP‐3, TIMP‐4, periostin, and tenascin C in tissue homogenates of 51 patients with chronic rhinosinusitis with and without nasal polyps and 15 control subjects were measured and were analyzed by adjusted logistic regression and spearman correlation test. Primary human nasal polyp fibroblasts and epithelial cells were stimulated ex vivo with periostin and tenascin C and the gene expression of MMPs and TIMPs was determined by means of real‐time PCR.ResultsThe protein levels of MMP‐3, MMP‐7, MMP‐8, MMP‐9, TIMP‐1, TIMP‐2, periostin, and tenascin C were significantly higher in patients with CRSwNPs than in healthy control subjects. The adjusted logistic regression analyses showed that MMP‐3, MMP‐7, MMP‐8, MMP‐9, TIMP‐2, periostin, and tenascin C were related to the occurrence of CRSwNP. Spearman correlation test showed periostin was positively correlated with MMP‐3 and TIMP‐2, and tenascin C was positively correlated with MMP‐3, MMP‐7, MMP‐8, MMP‐9, and TIMP‐2. Periostin stimulated the gene expression of MMP‐3, MMP‐7, MMP‐8, and MMP‐9 in fibroblasts and MMP‐9 in epithelial cells ex vivo. Tenascin C stimulated the expression of MMP‐3, MMP‐7, MMP‐8, and MMP‐9 in epithelial cells. The expression of TIMPs in fibroblasts and epithelial cells was affected by neither periostin nor tenascin C.ConclusionsPeriostin and tenascin C might be involved in the remodeling of nasal polyps by regulating the expression of different MMPs in epithelial cells and fibroblasts. Our findings have the potential to identify key factors of tissue remodeling in CRSwNPs.
DNA Framework‐Mediated Geometric Renormalization of Gold Nanoparticles on a Two‐Dimensional Fluidic Membrane Interface
Authors: Guo Ruiyan , Li Min , Zuo Xiaolei 
Published: September 2021

AbstractThe precise arrangement of single entity is a crucial objective of nanoscience and holds great promise in various fields such as biology and material science. In this work, we develop a “DNA framework‐mediated geometric renormalization” (DFMGR) strategy to reassemble gold nanoparticles into specific geometric shapes on a 2‐dimensional (2D) fluidic membrane interface. Cholesterol‐modified AuNPs are randomly anchored on the supported lipid bilayer (SLB) via the cholesterol‐lipid interaction. We demonstrate that AuNPs are laterally mobile on SLB and could be further rearranged into a specific geometric shape by DNA framework containing algebraically topological DNA arms. Using scanning electron microscope (SEM) imaging approach, simple geometric shapes, such as points assembled by monomers, line segments assembled by dimers, triangles assembled by trimers are visually presented. Interestingly, we found that the statistic angle (58.77°) and side length (12.21 nm) of triangles obtained from SEM images were both agreed well with the theoretical angle of 60° and side length of 12.58 nm. And the relative error of the angle calculated was as low as 0.33 %. These results indicated that the DFMGR strategy showed precise regulation ability for the AuNPs renormalization. We believe that DNA framework‐mediated geometric renormalization strategy would be a powerful means for regulating ligand‐receptor interactions in biosystems and for nanoparticle assembling in material science.
Long‐term stand‐level resilience in natural secondary forest stands recovering from severe windthrow damage
Authors: Shibuya Masato 
Published: September 2021

AbstractLong‐term stand‐level resilience in three natural secondary forests after a stand‐replacing windthrow damage event was examined by analyzing stand composition, structure, and function using repetitive measurement data collected in permanent plots over 60 yr. The secondary forests differed among pre‐disturbance forest types. For the purposes of this study, stand resilience comprised resistance to and recovery from windthrow damage. To analyze composition, the dynamics of species numbers in the permanent plots were tracked and temporal trends in similarity between pre‐ and post‐disturbance compositions were examined. To investigate stand structure, the dynamics of tree density, mean diameter at breast height (DBH), and temporal trends in similarity between pre‐ and post‐disturbance DBH frequency distributions were analyzed. To investigate stand function, the dynamics of stand basal area were analyzed. The calculations showed that tree density, basal area, species composition, and DBH frequency distribution were associated with low resistance to windthrow damage. By contrast, the number of species and mean DBH were resistant to windthrow damage. Basal areas recovered quickly in the 60 yr post‐windthrow damage, but recovery of the pre‐damage mean DBH and DBH frequency distribution was slow. Tree density and the number of species recovered to levels that exceeded those in the stands prior to the windthrow event. The recovery of species composition varied by pre‐disturbance forest type. Among the stands analyzed, the hardwood forest that existed prior to disturbance was resistant to and recovered well from windthrow damage in comparison with other types of pre‐disturbance forests. In conclusion, stand‐replacing windthrow damage can have a long‐lasting influence on secondary forests, especially in terms of stand composition and structure.
Technological characteristics of inulin enriched gluten‐free bread: Effect of acorn flour replacement and fermentation type
Authors: Shiri Ameneh , Ehrampoush Mohammad Hassan , Yasini Ardakani Seyed Ali , Shamsi Farimah , Mollakhalili‐Meybodi Neda 
Published: September 2021

AbstractTextural, physicochemical, and sensory characteristics of rice‐based gluten‐free bread in the presence of acorn flour; inulin and different fermentation type (yeast starter fermentation [Y] or mixed fermentation based on sourdough [MF‐SD]) were investigated. Acorn flour was added to replace rice flour at a proportion of 10, 30, and 50% W/W. Furthermore, the mixture flour was replaced by inulin as a functional prebiotic ingredient at 10% W/W. Considering results obtained at this study, using mixed fermentation based on sourdough and inulin at 10% W/W provide the structure able to restore gases through baking process at formulations containing acorn flour at 30% W/W (A30R70SL). The highest specific volume (1.47 ± 0.04 cm3 g−1) and the lowest hardness (40.97 ± 0.87 N) are observed in A30R70SL which seems to be induced by its potential to form gel. Acorn flour substitution level at 50% W/W adversely influenced the technological characteristics of final product and its perception by the consumer. Acorn flour substitution up to 30% W/W is preferred by the consumer which is attributed to its potential role to improve the unpleasant pale color of rice‐based gluten‐free products. A negatively significant correlation has been observed between the color perception by the consumer and crumb lightness (r = −.493, p ≤ .05).
Development of the visual white matter pathways mediates development of electrophysiological responses in visual cortex
Authors: Caffarra Sendy , Joo Sung Jun , Bloom David , Kruper John , Rokem Ariel , Yeatman Jason D. 
Published: September 2021

AbstractThe latency of neural responses in the visual cortex changes systematically across the lifespan. Here, we test the hypothesis that development of visual white matter pathways mediates maturational changes in the latency of visual signals. Thirty‐eight children participated in a cross‐sectional study including diffusion magnetic resonance imaging (MRI) and magnetoencephalography (MEG) sessions. During the MEG acquisition, participants performed a lexical decision and a fixation task on words presented at varying levels of contrast and noise. For all stimuli and tasks, early evoked fields were observed around 100 ms after stimulus onset (M100), with slower and lower amplitude responses for low as compared to high contrast stimuli. The optic radiations and optic tracts were identified in each individual's brain based on diffusion MRI tractography. The diffusion properties of the optic radiations predicted M100 responses, especially for high contrast stimuli. Higher optic radiation fractional anisotropy (FA) values were associated with faster and larger M100 responses. Over this developmental window, the M100 responses to high contrast stimuli became faster with age and the optic radiation FA mediated this effect. These findings suggest that the maturation of the optic radiations over childhood accounts for individual variations observed in the developmental trajectory of visual cortex responses.
REDV‐modified decellularized microvascular grafts for arterial and venous reconstruction
Authors: Yamanaka Hiroki , Mahara Atsushi , Morimoto Naoki , Yamaoka Tetsuji 
Published: September 2021

AbstractRecently, a decellularized microvascular graft (inner diameter: 0.6 mm) modified with the integrin α4β1 ligand, REDV, was developed to provide an alternative to autologous‐vein grafting in reconstructive microsurgery, showing good early‐stage patency under arterial flow in rats. This consecutive study evaluated its potential utility not only as an arterial substitute, but also as a venous substitute, using a rat‐tail replantation model. Graft remodeling depending on hemodynamic status was also investigated. ACI rat tail arteries were decellularized via ultra‐high‐hydrostatic pressure treatment and modified with REDV to induce antithrombogenic interfaces and promote endothelialization after implantation. Grafts were implanted into the tail artery and vein to re‐establish blood circulation in amputated Lewis rat tails (n = 12). The primary endpoint was the survival of replants. Secondary endpoints were graft patency, remodeling, and regeneration for 6 months. In all but three cases with technical errors or postoperative self‐mutilation, tails survived without any evidence of ischemia or congestion. Six‐month Kaplan–Meier patency was 100% for tail‐artery implanted grafts and 62% for tail‐vein implanted grafts. At 6 months, the neo‐tunica media (thickness: 95.0 μm in tail‐artery implanted grafts, 9.3 μm in tail‐vein implanted grafts) was regenerated inside the neo‐intima. In conclusion, the microvascular grafts functioned well both as arterial and venous paths of replanted‐rat tails, with different remodeling under arterial and venous conditions.
Controlled Formation of Carboxymethyllysine in Bone Matrix through Designed Glycation Reaction
Authors: Sroga Grażyna E. , Vashishth Deepak 
Published: September 2021

ABSTRACTIt has been a challenge to establish a link between specific advanced glycation end products (AGEs) as causal agents of different pathologies and age‐related diseases, primarily because of the lack of suitable in vitro experimental strategies facilitating increased formation of a specific AGE, here carboxymethyllysine (CML), over other AGEs under controlled conditions. CML is of considerable importance to various oxidative stress–related diseases, because in vivo formation of this AGE is connected with cellular oxidative/carbonyl metabolism. The mechanistic implications of CML accumulation in bone remain to be elucidated. To facilitate such studies, we developed a new in vitro strategy that allows preferential generation of CML in bone matrix over other AGEs. Using bone samples from human donors of different age (young, middle‐age, and elderly), we show successful in vitro generation of the desired levels of CML and show that they mimic those observed in vivo in several bone disorders. Formation of such physiologically relevant CML levels was achieved by selecting two oxidative/carbonyl stress compounds naturally produced in the human body, glyoxal and glyoxylic acid. Kinetic studies using the two compounds revealed differences not only between their reaction rates but also in the progression and enhanced formation of CML over other AGEs (measured by their collective fluorescence as fluorescent AGEs [fAGEs]) Consequently, through the regulation of reaction time, the levels of CML and fAGEs could be controlled and separated. Given that the developed approach does not fully eliminate the formation of other uncharacterized glycation products, this could be considered as the study limitation. We expect that the concepts of our experimental approach can be used to develop diverse strategies facilitating production of the desired levels of selected AGEs in bone and other tissues, and thus, opens new avenues for investigating the role and mechanistic aspects of specific AGEs, here CML, in bone. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Social anxiety, rejection sensitivity, and theory of mind decoding ability
Authors: Lord Kayla A. , Suvak Michael K. , Liverant Gabrielle I. 
Published: September 2021

AbstractObjectives:Recent initiatives have highlighted the importance of investigating clinically relevant variations in social processes that contribute to mental illness. Surprisingly little research has examined the associations between socially and clinically relevant transdiagnostic factors, such as social anxity (SA) and rejection sensitvity (RS), on theory of mind (ToM) decoding ability.Methods:The Reading the Mind in the Eyes Task and self‐report measures of SA and RS were completed by 199 adult participants.Results:Linear regression analyses suggest a specific difficulty decoding positive emotion associated with SA and global decrements in ToM associated with RS that may reflect a negative interpretation bias.Conclusions:These findings may have important implications for understanding how those with SA and RS perceive and navigate social interactions, which may contribute to the maintenance of symptoms and decreased psychosocial functioning.
Dynamics of risk: Recent changes in psychological inflexibility precede subsequent changes in returning US veterans' posttraumatic stress
Authors: Crabtree Meghan A. , Hale Willie J. , Meyer Eric C. , Kimbrel Nathan A. , DeBeer Bryann B. , Gulliver Suzy B. , Morissette Sandra B. 
Published: September 2021

AbstractObjectivesAs a malleable risk‐factor, psychological inflexibility is implicated in the development and maintenance of posttraumatic stress symptoms (PTS). Unfortunately, limited research has addressed whether changes in psychological inflexibility are antecedent to changes in PTS severity over time, or whether such changes are mutually dependent.MethodsUtilizing bivariate latent difference score modeling, this longitudinal study sequenced intraindividual changes in psychological inflexibility and PTS severity within a sample of 305 returning US veterans. Veterans' self‐reported psychological inflexibility and PTS severity were assessed quarterly over 1 year.ResultsResults indicated that early reductions in psychological inflexibility potentiated later declines in veterans' PTS severity, accounting for veterans' prior levels of psychological inflexibility and PTS severity.ConclusionsThese findings underscore the unique role ofchangesin psychological inflexibility as an important mechanism of change in PTS severity and provide empirical support for an antecedent model of the role of psychological inflexibility in PTS recovery.
Cannabinoid receptor 2 selective agonists and Alzheimer's disease: An insight into the therapeutic potentials
Authors: Magham Sai Varshini , Thaggikuppe krishnamurthy Praveen , Shaji Neenu , Mani Lalithkumar , Balasubramanian Shivaramakrishnan 
Published: September 2021

AbstractEndocannabinoid system has been extensively studied in recent decades, particularly the cannabinoid receptors CB1 and CB2, due to their important role in neuroinflammation. Among these, CB2 has gained prominence due to its selective overexpression in glial cells during neuroinflammation. In contrast to CB1 agonists, CB2 agonists have no side effects such as ataxia, hypothermia, euphoria, psychological, or addiction liabilities. CB2 and its selective agonists' above‐mentioned unique properties have become a research focus in neurodegenerative disorders such as Alzheimer's disease (AD). The review discusses the neuroprotective role of CB receptors, particularly CB2, in AD, as well as the significance and limitations of this research.
Compact full‐color laser beam scanning image projector based on a waveguide‐type RGB combiner
Authors: Nakao Akira , Yamada Shoji , Katsuyama Toshio , Kawasaki Osamu , Iwabata Kazuki , Yabe Yuuta , Horii Koichi , Himeno Akira 
Published: September 2021

AbstractA packaged red‐green‐blue (RGB) laser module based on a waveguide‐type combiner is demonstrated. The module has characteristic features such as (a) a compact size and lightweight, (b) almost perfectly aligned RGB laser beams owing to a single waveguide output, and (c) a configuration with only a few mechanical elements. The typical package size is 10 × 5 × 5 mm for an outside focusing lens type and 11 × 4.8 × 3 mm for an inside focusing lens type. Light intensity monitors and a temperature monitor are also equipped for the inside focusing lens type.Furthermore, a compact RGB laser beam scanning module is demonstrated. Clear full‐color high‐definition video images are obtained. Thus, these modules based on waveguide‐type combiners can provide compact imaging projectors with clear images. Compact Lidar scanners and laser sources for various sensors are also candidate applications.
A survey evaluation comparing pain curriculum taught in Australian exercise physiology degrees to graduate perceptions of their preparedness and competency to treat people with chronic pain
Authors: Jones Matthew D. , Cashin Aidan G. , Mouatt Brendan , McLeod Kelly A. , Mundell Niamh L. , McAuley James H. , Booth John 
Published: September 2021

AbstractBackground and AimsThis cross‐sectional study evaluated the nature of pain curriculum being taught in accredited exercise physiology degrees across Australian universities and its perceived usefulness for preparing exercise physiologists to treat people with chronic pain.Materials & MethodsUniversities and graduates were asked about the nature and sufficiency of pain curriculum taught, with particular emphasis on competencies for physical therapists as outlined by the International Association for the Study of Pain.ResultsTen universities and 101 graduates responded. Median (interquartile range) instruction time on pain curriculum was 12 (7.25–18.75) hours. Few universities (30%) were aware of the guidelines for physical therapy pain curricula, although most (70%) agreed their degrees contained adequate instruction on pain assessment and management. In contrast, 74% of graduates felt their degree did not adequately prepare them to treat people with chronic pain. Half the graduates (51%) were not aware of the guidelines for physical therapy pain curricula.Discussion & ConclusionThere is a disconnect between perceptions of Australian universities and their graduates regarding the sufficiency of pain curriculum taught to student exercise physiologists. Benchmarking pain curriculum in Australian university programs against relevant international recommendations may enhance the suitability of pain curricula taught to exercise physiologists, thereby better preparing new graduates to treat people with pain.
Multiple pneumatoceles and diffuse ground‐glass opacities in a 20‐month‐old boy with COVID‐19 pneumonia
Authors: Özgür Cihan , Doğan Caner 
Published: September 2021

Key messageChest computed tomography characteristics of coronavirus disease 2019 (COVID‐19) in paediatric patients have been reported to be atypical and different compared to adults. Although pneumatocele has not been reported in paediatric COVID‐19 pneumonia cases in the literature, physician should be familiar with atypical imaging findings.
Tandem Reaction of Phenyl α‐Cyano‐α‐arylacetates with Quinone Monoimines
Authors: Cheng Shao‐Bing , Jing Yi , Cao Lian‐Yi , Li Wen‐Zhe , Zhang Xiao‐Mei 
Published: September 2021

AbstractA tandem reaction of phenyl α‐cyano‐α‐arylacetates with quinone monoimines was presented, which allowed for the synthesis of various 2‐aminobenzofuran derivatives in low to moderate yields. This method is applicable to a series of phenyl α‐cyano‐α‐arylacetates with various aryl groups and quinone monoimines with different substituents. In addition, a pausible mechanism was proposed.
Nanostructured Substrates as Matrices for Surface Assisted Laser Desorption/Ionization Mass Spectrometry: A Progress Report from Material Research to Biomedical Applications
Authors: Ma Wen , Li Jun , Li Xianjiang , Bai Yu , Liu Huwei 
Published: September 2021

AbstractWithin the past two decades, the escalation of research output in nanotechnology fields has boosted the development of novel nanoparticles and nanostructured substrates for use as matrices in surface assisted laser desorption/ionization mass spectrometry (SALDI‐MS). The application of nanomaterials as matrices, rather than organic matrices, offers remarkable characteristics that allow the analysis of small molecules with fewer matrix interfering peaks, and share higher detection sensitivity, specificity, and reproducibility. The technological advancement of SALDI‐MS has in turn, propelled the application of the analytical technique in the field of biomedical analysis. In this review, the properties and fabrication methods of nanostructured substrates in SALDI‐MS such as metallic‐, carbon‐, and silicon‐based nanostructures, quantum dots, metal‐organic frameworks, and covalent‐organic frameworks are described. Additionally, the latest progress (most within 5 years) of biomedical applications in small molecule, large biomolecule, and MS imaging analysis including metabolite profiling, drug monitoring, bacteria identification, disease diagnosis, and therapeutic evaluation are demonstrated. Key parameters that govern nanomaterial's SALDI efficiency in biomolecule analysis are also discussed. Finally, perspectives of the future development are given to provide a better advancement and promote practical application in clinical MS.