bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic indicators for naïve canine non‐indolent T‐cell lymphoma treated with combination lomustine, vincristine, procarbazine and prednisolone chemotherapy
Authors: Blaxill John , Buzzacott Peter , Finlay Jessica 
Published: August 2021

AbstractLomustine, vincristine, procarbazine and prednisolone (LOPP) chemotherapy has been suggested to be an effective treatment for dogs with naïve non‐indolent T‐cell lymphoma (TCL). Studies evaluating prognostic factors for dogs with TCL treated with LOPP chemotherapy are lacking. The aim of this retrospective study was to assess potential prognostic factors for canine naïve non‐indolent TCL treated with the LOPP protocol. This was a retrospective cohort study of naïve non‐indolent TCL treated with the LOPP chemotherapy protocol at a single specialty veterinary oncology clinic. Sixty‐seven dogs met the inclusion criteria. The outcomes assessed included progression free survival (PFS), overall survival time (OST) and duration of complete response (DCR). The overall median PFS was 118 days (range 7–2302 days). The median OST was 202 days (range 8–2302 days). The overall median DCR was 316 days (range 38–2261 days). Number of treatments administered (p < .0001), multicentric disease (p = .044) and the presence of hypercalcaemia (p = .006) were prognostic indicators for PFS. Increasing number of treatments (p < .0001) and age (p = .0088) were prognostic indicators for OST. To our knowledge, this is the first study to describe hypercalcaemia as a positive prognostic indicator of PFS for TCL treated with LOPP chemotherapy. LOPP chemotherapy can be considered as a first‐line treatment protocol against naïve hypercalcaemic non‐indolent TCL.
Effects of Grain Refinement on Rolling Contact Fatigue in Bearing Contacts
Authors: Lorenz Steven J. , Sadeghi Farshid , Trivedi Hitesh K. , Kirsch Mathew S. , Wang Chinpei 
Published: August 2021

Abstract
This paper presents a finite element model (FEM) to investigate the effect of prior austenite grain refinement on rolling contact fatigue (RCF). RCF life was determined using continuum damage mechanics (CDM), which simulated material deterioration as a function of cycle. Continuum damage mechanics calculations in this investigation considered the subsurface shear (orthogonal) reversal to be responsible for RCF failure. To establish the CDM critical parameters—resistance stress (σr) and damage rate exponent (m)—torsion stress-life data from open literature of three different grain sizes for the same material was used. It was observed from the torsion S-N (stress-life) data that the resistance stress exhibits a linear relationship with grain diameter. As grain diameter was refined, the resistance stress was found to increase. The damage rate exponent (m) displayed no relation to grain diameter; hence, the average value from the three torsion S-N curves was used in this investigation. In order to assess the effect of grain refinement on RCF life, a series of unique material microstructures were constructed using the Voronoi tessellation process at eight mean grain diameters. Finite element (FE) simulations were devised at three contact pressures, typical of heavily loaded lubricated contacts, and the RCF life was determined for each set of microstructures of a given mean grain diameter. The RCF results at the eight grain diameters indicate that fatigue performance is improved exponentially with finer grain diameter. The observed life improvements from the RCF simulations resulting from grain refinement exhibit good corroboration with existing experimental results found in open literature. A single predictive fatigue life equation was constructed from this investigation’s RCF simulations to evaluate the stochastic RCF performance, given grain diameter and contact pressure, of non-conformal contacts.
Trends in Meeting the Physical Activity Guidelines: Muscle-Strengthening Alone and Combined With Aerobic Activity, United States, 1998–2018
Authors: Hyde Eric T. , Whitfield Geoffrey P. , Omura John D. , Fulton Janet E. , Carlson Susan A. 
Published: August 2021

Background: The National Health Interview Survey is unique among US federal surveillance systems with over 20 years of consistent assessment of muscle-strengthening and aerobic activity. The authors examined trends in the prevalence of US adults who met the muscle-strengthening (2 or more days per week) and the combined muscle-strengthening and aerobic physical activity (at least 150 min/wk of moderate-intensity equivalent activity) guidelines from 1998 to 2018. Methods: The 1998–2018 National Health Interview Survey data were analyzed. Age-adjusted prevalence of meeting the muscle-strengthening and combined aerobic and muscle-strengthening guidelines by selected respondent characteristics were estimated for each year and linear and higher-order trends were assessed. Results: From 1998 to 2018, prevalence of meeting the muscle-strengthening guideline increased from 17.7% to 27.6%, and meeting the combined aerobic and muscle-strengthening guidelines increased from 14.4% to 24.0%. All subgroups demonstrated significant increases in meeting both guideline measures over this period although trends varied across the 21 years; increasing trends were more commonly sustained in the second decade of monitoring. Conclusions: Although increasing trends in prevalence of meeting the muscle-strengthening and combined guidelines are encouraging, current prevalence estimates remain low. Opportunities exist for the continued promotion of muscle-strengthening activity using evidence-based approaches.
Trends in Self-Reported Sitting Time by Physical Activity Levels Among US Adults, NHANES 2007/2008–2017/2018
Authors: Ussery Emily N. , Whitfield Geoffrey P. , Fulton Janet E. , Galuska Deborah A. , Matthews Charles E. , Katzmarzyk Peter T. , Carlson Susan A. 
Published: August 2021

Background: High levels of sedentary behavior and physical inactivity increase the risk of premature mortality and several chronic diseases. Monitoring national trends and correlates of sedentary behavior and physical inactivity can help identify patterns of risk in the population over time. Methods: The authors used self-reported data from the National Health and Nutrition Examination Surveys (2007/2008–2017/2018) to estimate trends in US adults’ mean daily sitting time, overall, and stratified by levels of leisure-time and multidomain physical activity, and in the joint prevalence of high sitting time (>8 h/d) and physical inactivity. Trends were tested using orthogonal polynomial contrasts. Results: Overall, mean daily sitting time increased by 19 minutes from 2007/2008 (332 min/d) to 2017/2018 (351 min/d) (Plinear < .05; Pquadratic < .05). The highest point estimate occurred in 2013/2014 (426 min/d), with a decreasing trend observed after this point (Plinear < .05). Similar trends were observed across physical activity levels and domains, with one exception: an overall linear increase was not observed among sufficiently active adults. The mean daily sitting time was lowest among highly active adults compared with less active adults when using the multidomain physical activity measure. Conclusions: Sitting time among adults increased over the study period but decreased in recent years.
Sex-Stratified Trends in Meeting Physical Activity Guidelines, Participating in Sports, and Attending Physical Education Among US Adolescents, Youth Risk Behavior Survey 2009–2019
Authors: Chen Tiffany J. , Watson Kathleen B. , Michael Shannon L. , Carlson Susan A. 
Published: August 2021

Background: During the past decade, guidelines for youth aerobic and muscle-strengthening physical activity remained unchanged. Active People, Healthy NationSM highlighted school and youth strategies (eg, sports and physical education [PE]) to increase physical activity. Sex, grade, and race/ethnicity disparities exist. This study examines sex-specific trends and differences by grade and race/ethnicity for the prevalence of 5 youth physical activity behaviors from 2009 to 2019. Methods: The national Youth Risk Behavior Survey assesses adolescents (grades 9–12) meeting the aerobic, muscle-strengthening, and both guidelines (2011–2019) and sports participation and daily PE (2009–2019). Sex-stratified logistic regression assessed trends and 2009 or 2011–2019 differences by grade and racial/ethnic subgroups. Results: Decreases in meeting the aerobic, muscle-strengthening, and both guidelines were observed for nearly all male subgroups by grade and race/ethnicity, whereas female subgroups exhibited declines or no change to low prevalence. Sports and PE participation remained mostly constant; select subgroups showed decreases (ie, Hispanic males [sports]; Black males and ninth-grade females [PE]). Conclusions: Past decade prevalence and patterns suggest that school-based and other strategies for all adolescents and tailored interventions for sex-specific subgroups may be needed to supplement sports and PE in promoting high school youth physical activity.
Foodborne Illness Outbreak Investigation for One Health Postsecondary Education
Authors: Shearer Adrienne E. H. , Kniel Kalmia E. 
Published: August 2021

One Health concepts were incorporated in a foodborne disease outbreak investigation with game features of data presented as visual and manipulative clues. Postsecondary pre-veterinary medicine and animal biosciences students and food science students (
n
= 319) enrolled in an introductory animal and food sciences course over a 3-year period received a brief introduction to foodborne illness, an outbreak scenario, and investigative tasks to complete individually or in groups.
Cardiovascular care of older adults
Authors: O’Neill Deirdre E , Forman Daniel E 
Published: August 2021

ABSTRACT
Age is an independent risk factor for cardiovascular disease. With the accelerated growth of the population of older adults, geriatric and cardiac care are becoming increasingly entwined. Although cardiovascular disease in younger adults often occurs as an isolated problem, it is more likely to occur in combination with clinical challenges related to age in older patients. Management of cardiovascular disease is transmuted by the context of multimorbidity, frailty, polypharmacy, cognitive dysfunction, functional decline, and other complexities of age. This means that additional insight and skills are needed to manage a broader range of relevant problems in older patients with cardiovascular disease. This review covers geriatric conditions that are relevant when treating older adults with cardiovascular disease, particularly management considerations. Traditional practice guidelines are generally well suited for robust older adults, but many others benefit from a relatively more personalized therapeutic approach that allows for a range of medical circumstances and idiosyncratic goals of care. This requires weighing of risks and benefits amidst the patient’s aggregate clinical status and the ability to communicate effectively about this with patients and, where appropriate, their care givers in a process of shared decision making. Such a personalized approach can be particularly gratifying, as it provides opportunities to optimize an older patient’s function and quality of life at a time in life when these often become foremost therapeutic priorities.
On the existence and stability of traversable wormhole solutions in modified theories of gravity
Authors: Sokoliuk Oleksii , Baransky Alexander 
Published: August 2021

AbstractWe study Morris–Thorne static traversable wormhole solutions in different modified theories of gravity. We focus our study on the quadratic gravity $$f({\mathscr {R}}) = {\mathscr {R}}+a{\mathscr {R}}^2$$

f

(
R
)

=
R
+
a

R

2

, power-law $$f({\mathscr {R}}) = f_0{\mathscr {R}}^n$$

f

(
R
)

=

f
0

R

n

, log-corrected $$f({\mathscr {R}})={\mathscr {R}}+\alpha {\mathscr {R}}^2+\beta {\mathscr {R}}^2\ln \beta {\mathscr {R}}$$

f

(
R
)

=
R
+
α

R

2

+
β

R

2

ln
β
R

theories, and finally on the exponential hybrid metric-Palatini gravity $$f(\mathscr {\hat{R}})=\zeta \bigg (1+e^{-\frac{\hat{{\mathscr {R}}}}{\varPhi }}\bigg )$$

f

(

R
^

)

=
ζ

(

1
+

e

-

R
^

Φ

)

. Wormhole fluid near the throat is adopted to be anisotropic, and redshift factor to have a constant value. We solve numerically the Einstein field equations and we derive the suitable shape function for each MOG of our consideration by applying the equation of state $$p_t=\omega \rho $$

p
t

=
ω
ρ

. Furthermore, we investigate the null energy condition, the weak energy condition, and the strong energy condition with the suitable shape function b(r). The stability of Morris–Thorne traversable wormholes in different modified gravity theories is also analyzed in our paper with a modified Tolman–Oppenheimer–Voklov equation. Besides, we have derived general formulas for the extra force that is present in MTOV due to the non-conserved stress-energy tensor.
Chronicle of the discovery of the back-bending phenomenon in atomic nuclei: a personal recollection 50 years on
Authors: Ryde Hans 
Published: August 2021

AbstractA chronicle describing the historical context and the development of ideas and experiments leading to the discovery of the back-bending phenomenon in rapidly rotating atomic nuclei some 50 years ago is presented. The moment of inertia of some atomic nuclei increases anomalously at a certain rotational frequency, revealing important clues to our understanding of nuclear structure. I highlight the decisive interactions and contacts between experimentalists and theorists, which created the right environment, allowing for the revelation of an undetected phenomenon in Nature. Finally, I reflect on the key points allowing for the discovery and particularly point to the importance of systematic surveys, which in this case investigated the energy levels in heavy nuclei of a large sample of elements, as well as to the accuracy of the measurements of the ground state levels made at the time.
Association of Endogenous Pregnenolone, Progesterone, and Related Metabolites with Risk of Endometrial and Ovarian Cancers in Postmenopausal Women: The B∼FIT Cohort
Authors: Trabert Britton , Geczik Ashley M. , Bauer Doug C. , Buist Diana S.M. , Cauley Jane A. , Falk Roni T. , Gierach Gretchen L. , Hue Trisha F. , Lacey James V. , LaCroix Andrea Z. , Michels Kara A. , Tice Jeffrey A. , Xu Xia , Brinton Louise A. , Dallal Cher M. 
Published: August 2021

AbstractBackground:Postmenopausal pregnenolone and/or progesterone levels in relation to endometrial and ovarian cancer risks have been infrequently evaluated. To address this, we utilized a sensitive and reliable assay to quantify prediagnostic levels of seven markers related to endogenous hormone metabolism.Methods:Hormones were quantified in baseline serum collected from postmenopausal women in a cohort study nested within the Breast and Bone Follow-up to the Fracture Intervention Trial (B∼FIT). Women using exogenous hormones at baseline (1992–1993) were excluded. Incident endometrial (n = 65) and ovarian (n = 67) cancers were diagnosed during 12 follow-up years and compared with a subcohort of 345 women (no hysterectomy) and 413 women (no oophorectomy), respectively. Cox models with robust variance were used to estimate cancer risk.Results:Circulating progesterone levels were not associated with endometrial [tertile (T)3 vs. T1 HR (95% confidence interval): 1.87 (0.85–4.11); Ptrend = 0.17] or ovarian cancer risk [1.16 (0.58–2.33); 0.73]. Increasing levels of the progesterone-to-estradiol ratio were inversely associated with endometrial cancer risk [T3 vs. T1: 0.29 (0.09–0.95); 0.03]. Increasing levels of 17-hydroxypregnenolone were inversely associated with endometrial cancer risk [0.40 (0.18–0.91); 0.03] and positively associated with ovarian cancer risk [3.11 (1.39–6.93); 0.01].Conclusions:Using sensitive and reliable assays, this study provides novel data that endogenous progesterone levels are not strongly associated with incident endometrial or ovarian cancer risks. 17-hydroxypregnenolone was positively associated with ovarian cancer and inversely associated with endometrial cancer.Impact:While our results require replication in large studies, they provide further support of the hormonal etiology of endometrial and ovarian cancers.
Antibody–Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization
Authors: Buongervino Samantha , Lane Maria V. , Garrigan Emily , Zhelev Doncho V. , Dimitrov Dimiter S. , Bosse Kristopher R. 
Published: August 2021

Abstract
Antibody–drug conjugates (ADC) are a targeted cancer therapy that utilize the specificity of antibodies to deliver potent drugs selectively to tumors. Here we define the complex interaction among factors that dictate ADC efficacy in neuroblastoma by testing both a comprehensive panel of ADC payloads in a diverse set of neuroblastoma cell lines and utilizing the glypican 2 (GPC2)-targeting D3-GPC2-PBD ADC to study the role of target antigen density and antibody internalization in ADC efficacy in neuroblastoma. We first find that DNA binding drugs are significantly more cytotoxic to neuroblastomas than payloads that bind tubulin or inhibit DNA topoisomerase 1. We additionally show that neuroblastomas with high expression of the ABCB1 drug transporter or that harbor a TP53 mutation are significantly more resistant to tubulin and DNA/DNA topoisomerase 1 binding payloads, respectively. Next, we utilized the GPC2-specific D3-GPC2-IgG1 antibody to show that neuroblastomas internalize this antibody/GPC2 complex at significantly different rates and that these antibody internalization kinetics correlate significantly with GPC2 cell surface density. However, sensitivity to pyrrolobenzodiazepine (PBD) dimers primarily dictated sensitivity to the corresponding D3-GPC2-PBD ADC, overall having a larger influence on ADC efficacy than GPC2 cell surface density or antibody internalization. Finally, we utilized GPC2 isogenic Kelly neuroblastoma cells with different levels of cell surface GPC2 expression to define the threshold of target density required for ADC efficacy. Taken together, DNA binding ADC payloads should be prioritized for development for neuroblastoma given their superior efficacy and considering that ADC payload sensitivity is a major determinant of ADC efficacy.
Centromere Protein A Goes Far Beyond the Centromere in Cancers
Authors: Liu Xiaolan , Wang Haiping , Zhao Guojun 
Published: August 2021

Abstract

Centromere dysfunctions leading to numerical chromosome alterations are believed to be closely related to human cancers. As a centromere-specific protein, centromere protein A (CENP-A) replaces the histone H3 in centromeres and is therefore considered a key factor of centromere identity. Researches have shown that CENP-A is overexpressed in many types of human cancers. However, the behavior and function of CENP-A in tumorigenesis have not yet been systematically summarized. In this article, we describe the pleiotropic roles of CENP-A in human cells. Moreover, we provide a comprehensive review of the current knowledge on the relationship between aberrant expression and ectopic localization of CENP-A and tumorigenesis, and the mechanism of the ectopic deposition of CENP-A in cancers. Furthermore, we note that some oncogenic viruses can modulate the expression and localization of this centromere protein along with its chaperone. At last, we also discuss the therapeutic potential of targeting CENP-A for cancer therapy.
The rediscovery of Pimelodella longipinnis (Borodin, 1927), an enigmatic Atlantic Rainforest catfish species from Southeastern Brazil (Siluriformes: Heptapteridae)
Authors: Slobodian Veronica , Abreu-Santos Bruno , Pastana Murilo Nogueira de Lima 
Published: August 2021

This article is a redescription of Pimelodella longipinnis, an enigmatic catfish previously known only from its holotype and with uncertain type locality. The species is redescribed based on recently collected materials from streams of the Mata Atlântica bioregion, in Santos municipality, São Paulo State, Brazil. Pimelodella longipinnis is assigned to a putatively monophyletic group, the Pimelodella leptosoma-group, diagnosed by the presence of a supraoccipital process not reaching the anterior nuchal plate, with a gap of ca. 20-25% of the supraoccipital process total length, and whose tip notably surpasses the midpoint of the complex vertebra in dorsal view. We also present a list of fish species described from a shipping sent to the American Museum of Natural History from the former Museu Paulista (now Museu de Zoologia da Universidade de São Paulo), of which P. longipinnis was part.
Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse
Authors: Yu Mengyao , Kyryachenko Sergiy , Debette Stephanie , Amouyel Philippe , Schott Jean-Jacques , Le Tourneau Thierry , Dina Christian , Norris Russell A. , Hagège Albert A. , Jeunemaitre Xavier , Bouatia-Naji Nabila 
Published: August 2021

Background:
Mitral valve prolapse (MVP) is a common cardiac valve disease, which affects 1 in 40 in the general population. Previous genome-wide association study has identified 6 risk loci for MVP. But these loci explained only partially the genetic risk for MVP. We aim to identify additional risk loci for MVP by adding data set from the UK Biobank.

Methods:
We also incorporated 434 MVP cases and 4527 controls from the UK Biobank for discovery analyses. Genetic association was conducted using SNPTEST and meta-analyses using METAL. We used Functional Mapping and Annotation of Genome-Wide Association Studies for post-genome-wide association study annotations and Multi-marker Analysis of GenoMic Annotation for gene-based and gene-set analyses.

Results:

We found Trans-Omics for Precision Medicine imputation to perform better in terms of accuracy in the lower ranges of minor allele frequency below 0.1. Our updated meta-analysis included UK Biobank study for ≈8 million common single-nucleotide polymorphisms (minor allele frequency >0.01) and replicated the association on Chr2 as the top association signal near
TNS1
. We identified an additional risk locus on Chr1 (
SYT2
) and 2 suggestive risk loci on chr8 (
MSRA
) and chr19 (
FBXO46
), all driven by common variants. Gene-based association using Multi-marker Analysis of GenoMic Annotation revealed 6 risk genes for MVP with pronounced expression levels in cardiovascular tissues, especially the heart and globally part of enriched GO terms related to cardiac development.

Conclusions:
We report an updated meta-analysis genome-wide association study for MVP using dense imputation coverage and an improved case-control sample. We describe several loci and genes with MVP spanning biological mechanisms highly relevant to MVP, especially during valve and heart development.