bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contemporary Theatrical Landscapes: The Legacy of Romanticism in two examples of contemporary Australian Gothic drama
Authors: Hassall Linda 
Published: July 2021

At this time in history, climate change predicts that we are once again dwarfed by nature. Nature is as Massey (2008) suggests, understood as the classic foundations for our contemplation of place and our fascinations with belonging to place. As creative writers, artists and scholars respond to escalating temperatures, rising sea levels and natural disasters, on a daily basis, the threat of climate change events loom large in the contemporary imagination. Humankind’s pride in domination over all things natural is being put to the test, as we begin to anticipate the terrifying spectacle of our own damnation. From an ecological and eco-critical perspective, climate change may be considered, as the contemporary ‘abomination’ as it poses both a moral and a psychological paradox for us all. It is not an hallucinatory fantasy, nor is it a social pathology. Contemporary Australian Gothic drama explores the paradoxical relationship between perceptions of what is absent and what is present, between past and future, between climate, nature and disappearing landscapes and geographies. It is within this paradox of perception that Australian Gothic drama responds to literary legacies of Romanticism as we ‘lament the loss of spiritual connections’ to nature (Bate 1991: 17). This paper discusses the environmental and eco-critical themes embedded in two of my theatrical works, Dust 2016 and Salvation 2013, in which notions of evil in the Romantic sense are discovered in the ecologies of landscape, place and space from which we as humans are, in turn, becoming alienated.
THE TREATMENT EFFECT OF HYPERTENSION DRUGS OF PATIENTS WITH RENAL FAILURE STAGE IV
Authors: Hậu Phan Hùng Duy , Trí Bùi Đặng Minh , Bền Nguyễn Hữu 
Published: July 2021

Objectives: To evaluate the treatment effects of hypertension drugs in patients with stage IV renal failure at An Sinh General Hospital. Objects and methods: study of retrospective, cross-sectional description of 153 medical records of patients diagnosed with hypertension with stage IV chronic renal failure who were treated in the Department of Endocrinology - Dialysis of An Sinh General Hospital, Ho Chi Minh City, from June 1st, 2019 to May 31st, 2020. Results: After 6 months of follow-up of patients with hypertension at grade 2 and 3, there were only 11 patients. Normal/normal high blood pressure (BP) (<140/90mmHg) was achieved at 53.49%, however, target blood pressure (TBP) (<130/80 mmHg) was only reached in 33.99% of patients. Changes in renal function indexes after hemodialysis and after treatment had no significant
difference compared with before treatment with drugs of hypertension. The rate
of patients with new cardiovascular complications after 6 months of follow-up had a small rate of 3.27%. Conclusion: The ratio of patients with hypertension at grade 2 and grade 3 was clearly reduced. The TBP rate was in the average level. The rate of patients with new cardiovascular complications after 6 months of follow-up was low.
STUDY ON THE PRODUCTION PROCESS OF SINGLE DOSE MEASLES-RUBELLA COMBINED VACCINE AT POLYVAC
Authors: Huong Nguyen Thuy , Hoa Le Thi , Hung Le Quoc , Huong Ngo Thu , Hien Nguyen Dang 
Published: July 2021

Center for Research and Production of Vaccines and Biologicals (POLYVAC) has conducted “Study on the production process of single dose measles-rubella combined vaccine (MRVAC)” (1dose/vial) in lyophilized form to make it convenient to use for vaccination services and export. The results have determined the formulation of MRVAC final bulk, freeze-dried process. The quality of researched products met WHO and Vietnam Pharmacopoeia V standards in both visual tests of lyophilized vaccine cake and after being reconstituted with sterile water for injection, the titer of measles virus ranges from 4.03 to 4.28 lgPFU/0.5mL and titer of rubella virus is from 3.79 to 3.98 lgPFU/0.5 mL. Results on thermal stability test when incubating the vaccine at 37oC/7days, the titer of measles virus decreased from 0.79 to 0.96 lgPFU/ 0.5mL and titer of rubella virus decreased from 0 to 0.18 lgPFU/0.5mL. Residual moisture content ranges from 0.35 to 0.72%. pH of vaccine is stable, ranges from 7.42 to 7.62.
RESULTS OF TREATMENT OF CHILDREN WITH IDIOPATHIC NEPHROTIC SYNDROME AT BAC NINH OBSTETRIC AND CHILDREN'S HOSPITAL
Authors: Chi Vu Thi , Phuong Ta Thi Thanh , Kien Pham Trung 
Published: July 2021

Objectives: describe the clinical characteristics, laboratory findings and evaluate the results of treatment of idiopathic nephrotic syndrome in pediatric patients at Bac Ninh Obstetrics and Children’sHospital. Method: descriptive study. From January 1, 2020 to June 30, 2021.Result: Fiffty two children were recruited into the study sample. Males got involed in this disease more than females with a ratio male to female of 2.05/1 (there were 17 women and 35 men). The meanage was 6,75 years (from 1 to 15 years old), 55,8% of them were under 5 years old. The percentages of severe edema was 7,7%; increased blood pressure was 9.6%; anuria was 19.2%. The average 24-hour proteinuria was 143.46 mg/kg/day; average protein/creatinine ratio was 878.08 mg/mmol. The percentages of patient with good treatment results is 76.9%. Proteinuria, protein/creatinine in urinedecreased significantly after treatment (p<0.05). Blood albumin increased and cholesterol decreased significantly after treatment (p<0.05).Conclusion: Children with idiopathic nephrotic syndrome most were males, young age, severe edema, severe reduction in blood protein and proteinuria. The disease was completely treatable and monitored locally
UM VELHO MESTRE À ESPREITA: WILLY LEWIN LEITOR DE JOÃO CABRAL
Authors: Ribeiro Edneia Rodrigues 
Published: July 2021

Este trabalho pretende analisar o poema “A Willy Lewin morto”, a fim de apontar que uma suposta efeméride pode revelar, além do cunho afetivo, vínculos literários entre o, agora, poeta renomado e o seu mentor intelectual durante a juventude, no Recife. Como os estudos acerca de Willy Lewin são escassos, este trabalho se baseará nas referências ao longo da obra de João Cabral, em entrevistas, correspondências e informações obtidas em documentos de fontes primárias do espólio documental de João Cabral. Será discutido como Lewin, a quem é dedicado o principiante Pedra do sono (1942), é retomado nesse poema de Museu de tudo (1975), assumindo ares de leitor especializado de quem o poeta amadurecido busca “o sim e o desagrado”.
Anti-inflammatory roles of interleukin-35 in the pathogenesis of Japanese cedar pollinosis
Authors: Kouzaki Hideaki , Arai Yukihiro , Nakamura Keigo , Murao Takuya , Tojima Ichiro , Shimizu Shino , Yuta Atsushi , Shimizu Takeshi 
Published: July 2021

Background
Interleukin (IL)-35 has been recently identified as an anti-inflammatory cytokine in allergic inflammation. However, its biological role in the pathogenesis of allergic rhinitis has not been fully elucidated.

Objective
The purpose of this study was to investigate the anti-inflammatory activity of IL-35 in the pathogenesis of allergic rhinitis in patients with Japanese cedar pollinosis (JCP).

Methods
Peripheral blood mononuclear cells were collected from healthy controls and JCP patients during the off-season for pollen. Peripheral blood mononuclear cells were incubated with Cry j 1, a major allergen of Japanese cedar pollen and production of IL-5, IL-13, and IL-35 were measured by enzyme-linked immunosorbent assay. Th2 (CD4+ST2+) cells and group 2 innate lymphoid cells were isolated from peripheral blood mononuclear cells of JCP patients, and the inhibitory effects of IL-35 on cell differentiation, proliferation and mRNA expression of IL-5, IL-13, and GATA3 were examined. B cells were also isolated and the effects of IL-35 on total IgE production were examined.

Results
Cry j 1-induced production of IL-5 and IL-13 was significantly increased in peripheral blood mononuclear cells from JCP patients, whereas Cry j 1-induced IL-35 production was significantly decreased compared with healthy controls. IL-35 significantly inhibited Th2 cell differentiation, group 2 innate lymphoid cell proliferation, and mRNA expression of IL-5, IL-13, and GATA3 in Th2 cells and group 2 innate lymphoid cells. IL-35 also inhibited IgE production from B cells.

Conclusion
IL-35 is an important anti-inflammatory cytokine in JCP, and its biological roles include the downregulation of Th2 cells and group 2 innate lymphoid cells, and the inhibition of IgE production from B cells. These findings demonstrate that IL-35 may have the potential to exert anti-allergic effects for the treatment of allergic rhinitis.
Digitalisierung im Finanzdienstleistungssektor – Folgen für Angestelltenarbeit an der Front-Line
Authors: Tullius Knut 
Published: July 2021

Banken und Versicherungen in Deutschland durchlaufen seit einigen Jahren eine Phase der Restrukturierung und Rationalisierung, die wesentlich durch die Infragestellung bisheriger Wettbewerbsstrategien, Organisationsstrukturen und Beschäftigungssysteme durch „datengetriebene Geschäftsmodelle“ und die ihnen zugrundeliegenden Technologien geprägt ist – verbreitet ist von grundlegenden Umbrüchen, von „Disruption“, die Rede. Vorliegende empirische Studien dazu, was Banken und Versicherungen in Sachen Digitalisierung und Restrukturierung tatsächlich tun und welche Auswirkungen dies auf die Arbeit der Angestellten hat, sind indes ausschnitthaft. Auf Grundlage von Befunden aus zehn betrieblichen Fallstudien zeigt der Beitrag, dass die mit gegenwärtigen Digitalisierungs- und systemischen Rationalisierungsprozessen verbundenen Folgen für Dienstleistungsarbeit vielschichtig und teils widersprüchlich sind. Daraus folgt auch, dass pauschalisierende Aussagen zur Zukunft der Dienstleistungsarbeit, etwa im Sinne einer allgemeinen Tendenz zum „digitalen Taylorismus“, an den realen Veränderungen in den Betrieben vorbeigehen.
Gene Editing inPrunusSpp.: The Challenge of Adapting Regular Gene Transfer Procedures for Precision Breeding
Authors: Vergara Ricardo , Olivares Felipe , Olmedo Blanca , Toro Carolina , Muñoz Marisol , Zúñiga Carolina , Mora Roxana , Plantat Philippe , Miccono María , Loyola Rodrigo , Aguirre Carlos , Prieto Humberto 
Published: July 2021

Successfully gene editing (GE) in Prunus spp. has been delayed due to its woody nature presenting additional difficulties in both, proper regeneration protocols and designing efficient gene transfer techniques. The availability of adequate, single cell culture techniques for GE such as protoplast regeneration, is a limiting step for the genus and for this reason, the improvement of regular regeneration protocols and finding more efficient techniques for the delivery of the “editing reagents” seem to be a reasonable strategy to incorporate GE in the genus. During the last 10 years, we have focused our efforts optimizing some previous regeneration and gene transfer procedures for Japanese plum (P. salicina), sweet cherry (P. avium) and peach (P. persica) to incorporate them into a GE technology on these species. In parallel, delivery techniques for the CRISPR/Cas9 editing components, i.e., guide RNA (gRNA) and Cas9, have been developed with the aim of improving gene targeting efficiencies. In that line, using DNA virus-based replicons provides a significant improvement, as their replicational release from their carriers enables their enhanced expression. Here, we make a brief overview of the tissue culture and regeneration protocols we have developed for P. salicina, P. avium and P. persica, and then we proceed to describe the use of Bean yellow dwarf virus (BeYDV)-derived replicon vectors to express the editing reagents in vivo and to evaluate their editing capability on individuals derived from Agrobacterium-mediated gene transfer experiments of these species. We show part of our characterization assays using new BeYDV-derived vectors harboring multiple gRNAs, the Cas9 gene, and the green fluorescent protein reporter gene. We also describe a dedicated genome analysis tool, by which gRNA pairs can be designed to address gene deletions of the target genes and to predict off-target sequences. Finally, as an example, we show the general results describing GE of the peach TERMINAL FLOWER 1 gene and some preliminary characterizations of these materials.
The predatory bug Orius strigicollis shows a preference for egg-laying sites based on plant topography
Authors: Yu Chendi , Huang Jun , Ren Xiaoyun , Fernández-Grandon G Mandela , Li Xiaowei , Hafeez Muhammad , Lu Yaobin 
Published: July 2021

Background
Oviposition site selection is an important factor in determining the success of insect populations. Orius spp. are widely used in the biological control of a wide range of soft-bodied insect pests such as thrips, aphids, and mites. Orius strigicollis (Heteroptera: Anthocoridae) is the dominant Orius species in southern China; however, what factor drives its selection of an oviposition site after mating currently remains unknown.

Methods
Here, kidney bean pods (KBPs) were chosen as the oviposition substrate, and choice and nonchoice experiments were conducted to determine the preferences concerning oviposition sites on the KBPs of O. strigicollis. The mechanism of oviposition behavior was revealed through observation and measurement of oviposition action, the egg hatching rate, and the oviposition time.

Results
We found that O. strigicollis preferred the seams of the pods for oviposition, especially the seams at the tips of the KBPs. Choice and nonchoice experiments showed that females did not lay eggs when the KBP tail parts were unavailable. The rates of egg hatching on different KBP parts were not significantly different, but the time required for females to lay eggs on the tip seam was significantly lower. Decreased oviposition time is achieved on the tip seam because the insect can exploit support points found there and gain leverage for insertion of the ovipositor.

Discussion
The preferences for oviposition sites of O. strigicollis are significantly influenced by the topography of the KBP surface. Revealing such behavior and mechanisms will provide an important scientific basis for the mass rearing of predatory bugs.
Revisiting the need for radiation output measurements after X‐ray tube replacement in computed tomography
Authors: Stauduhar Paul J. , Jones A. Kyle 
Published: July 2021

AbstractPurposeState regulations require that CT radiation output be measured using a dosimeter after major service. The most common major service is tube replacement. We hypothesized that historical QC data could be used instead to determine if output measurements are necessary, potentially reducing the need for output measurements that require an on‐site visit by a qualified medical physicist.MethodsRecords of 65 original equipment manufacturer (OEM) tube replacements were reviewed to determine with what frequency output was outside the manufacturer's specifications. The previous 7 days of historical quality control (QC) data prior to a tube change was used to establish a baseline mean noise level and 95% inferential confidence intervals (ICIs) about the mean. This was compared to an ICI constructed using 7 days of QC data post‐tube change and the region of indifference. Different methods for acquiring samples of image noise were compared using a single factor analysis of variance (ANOVA).ResultsNone of the 65 tube replacements reviewed in this study resulted in an output change that exceeded the manufacturer's specifications. In all but one case, the results of the ICI analysis matched the measured output results. In the single case where results were discordant, the mean image noise was slightly higher after the tube change, which may have indicated the need for a larger sample size or service unrelated to the X‐ray tube, for example, system calibration. The method used to sample image noise did not significantly affect the calculated mean noise.ConclusionsThis review of historical OEM tube replacement data indicated the likelihood of output falling outside manufacturer specifications is low. Considering this, it is likely that using QC data from programs required by regulation and the American College of Radiology (ACR), medical physicists can reliably verify radiation output stability remotely instead of making measurements using a dosimeter.
Single‐Component Optogenetic Tools for Inducible RhoA GTPase Signaling
Authors: Berlew Erin E. , Kuznetsov Ivan A. , Yamada Keisuke , Bugaj Lukasz J. , Boerckel Joel D. , Chow Brian Y. 
Published: July 2021

AbstractOptogenetic tools are created to control RhoA GTPase, a central regulator of actin organization and actomyosin contractility. RhoA GTPase, or its upstream activator ARHGEF11, is fused to BcLOV4, a photoreceptor that can be dynamically recruited to the plasma membrane by a light‐regulated protein‐lipid electrostatic interaction with the inner leaflet. Direct membrane recruitment of these proteins induces potent contractile signaling sufficient to separate adherens junctions with as little as one pulse of blue light. Induced cytoskeletal morphology changes are dependent on the alignment of the spatially patterned stimulation with the underlying cell polarization. RhoA‐mediated cytoskeletal activation drives yes‐associated protein (YAP) nuclear localization within minutes and consequent mechanotransduction verified by YAP‐transcriptional enhanced associate domain transcriptional activity. These single‐transgene tools do not require protein binding partners for dynamic membrane localization and permit spatiotemporally precise control over RhoA signaling to advance the study of its diverse regulatory roles in cell migration, morphogenesis, and cell cycle maintenance.
Recent Progress in Essential Functions of Soft Electronic Skin
Authors: Chen Jianwen , Zhu Yutian , Chang Xiaohua , Pan Duo , Song Gang , Guo Zhanhu , Naik Nithesh 
Published: July 2021

AbstractInspired by the human skin, electronic skins (e‐skins) composed of various flexible sensors, such as strain sensor, pressure sensor, shear force sensor, temperature sensor, and humility sensor, and delicate circuits, are emerged to mimic the sensing functions of human skins. In this review, the strategies to realize the versatile functionalities of natural skin‐like e‐skins, including strain‐, pressure‐, shear force‐, temperature‐ and humility‐sensing abilities, as well as self‐healing ability and other functions are summarized. Some representative examples of high‐performance e‐skins and their applications are outlined and discussed. Finally, the outlook of the future of e‐skins is presented.
All‐Inorganic CsPbBr3 Perovskite Nanocrystals/2D Non‐Layered Cadmium Sulfide Selenide for High‐Performance Photodetectors by Energy Band Alignment Engineering
Authors: Peng Mingfa , Ma Yulong , Zhang Lei , Cong Shan , Hong Xuekun , Gu Yiheng , Kuang Yawei , Liu Yushen , Wen Zhen , Sun Xuhui 
Published: July 2021

AbstractPerovskites have attracted intensive attention as promising materials for the application in various optoelectronic devices due to their large light absorption coefficient, high carrier mobility, and long charge carrier diffusion length. However, the performance of the pure perovskite nanocrystals‐based device is extremely restricted by the limited charge transport capability due to the existence of a large number of the grain boundary between perovskite nanocrystals. To address these issues, a high‐performance photodetector based on all‐inorganic CsPbBr3 perovskite nanocrystals/2D non‐layered cadmium sulfide selenide heterostructure has been demonstrated through energy band engineering with designed typed‐II heterostructure. The photodetector exhibits an ultra‐high light‐to‐dark current ratio of 1.36 × 105, a high responsivity of 2.89 × 102 A W−1, a large detectivity of 1.28 × 1014 Jones, and the response/recovery time of 0.53s/0.62 s. The enhancement of the optoelectronic performance of the heterostructure photodetector is mainly attributed to the efficient charge carrier transfer ability between the all‐inorganic CsPbBr3 perovskites and 2D cadmium sulfide selenide resulting from energy band alignment engineering. The charge carriers’ transfer dynamics and the mechanism of the CsPbBr3 perovskites/2D non‐layered nanosheets interfaces have also been studied by state‐state PL spectra, fluorescence lifetime imaging microscopy, time‐resolved photoluminescence spectroscopy, and Kelvin probe force microscopy measurements.
Immune‐Modulating Mucin Hydrogel Microdroplets for the Encapsulation of Cell and Microtissue
Authors: Yan Hongji , Melin Marcus , Jiang Kun , Trossbach Martin , Badadamath Bharathesh , Langer Krzysztof , Winkeljann Benjamin , Lieleg Oliver , Hong Jaan , Joensson Haakan N. , Crouzier Thomas 
Published: July 2021

AbstractImmune‐modulating biomaterials used to encapsulate cells and microtissue transplants can be engineered to dampen the immune reaction and increase treatment efficacy. Mucin‐derived materials have gained attention for their ability to modulate macrophage and dendritic cell activity, and to trigger mild foreign body response when implanted in vivo. In this study, the potential of mucin hydrogels (Muc‐gels) as cell‐encapsulating materials is investigated. When placed in contact with blood, Muc‐gels trigger significantly lower complement activation, compared to clinical grade alginate hydrogels. Muc‐gel is a size‐selective barrier strongly hindering the diffusion of molecules with a hydrodynamic radius larger than 6 nm such as immunoglobulins. Muc‐gels support the growth of MIN6m9 insulin‐secreting cells into islet‐like organoids and the survival of primary human pancreatic islets, which maintained glucose responsiveness. Muc‐gels can be shaped into microdroplets in which MIN6m9 cells or cell aggregates can be encapsulated without loss of viability. Microdroplet encapsulation will allow transplants to be easily injected and improve their survival by favoring mass transport through the capsule. The combination of strong immune modulatory properties, appropriate selective barrier profile, biocompatibility for embedded cells Muc‐gels of particular value for microencapsulating cells or microtissues for transplantation.
Local Cracking‐Induced Scalable Flexible Silicon Nanogaps for Dynamically Tunable Surface Enhanced Raman Scattering Substrates
Authors: Qu Chunyan , Guo Qinglei , Huang Gaoshan , Mei Yongfeng 
Published: July 2021

AbstractSurface enhanced Raman scattering (SERS), as a promising and convenient analytical tool for molecule sensing, has turned out to be one of the most important applications of plasmonic nanostructures. However, its large‐area production, controllability, and adjustability remain significant challenges because of the weak control over the fabrication and spatial arrangement. Herein, a silicon nanogap array‐based flexible plasmonic substrate is developed, with capabilities of large‐area production, controllable arrangement, and width of nanogaps, by utilizing the standard microfabrication platform, and the fabricated flexible plasmonic substrate is further explored for dynamically tunable SERS for molecular sensing. After experimentally and theoretically optimizing the geometric designs of precursors, a 90 × 90 silicon nanogap array (over 1 cm × 1 cm) with a yield of about 99.74% is achieved. SERS is realized by depositing Au films onto the silicon nanogap. Dynamically tunable SERS is demonstrated by the thermally induced local stretch or contraction of silicon nanogaps, where the key parameters including Raman enhancement and sensitivity of the molecular sensor can be conveniently adjusted. These presented results significantly expand the scope of engineering opinions for flexible plasmonic nanostructures, which have many envisioned applications especially for environmental monitoring and biochemical detection.