bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association Between Depressive Symptoms and Insomnia in College Students in Qinghai Province: The Mediating Effect of Rumination
Authors: Xiao Shuheng , Liu Shuai , Zhang Puxiao , Yu Jia , A Huaihong , Wu Hui , Zhang Fabin , Xiao Yulan , Ma Naiben , Zhang Xiuqin , Ma Xiaoxia , Li Junfeng , Wang Xiaodun , Shao Xin , Liu Wenjing , Zhang Xiaolin , Wu Wei , Wang Lihua , Wu Rihan , He Yinglian , Xu Zeyu , Chi Luhao , Du Shixu , Zhang Bin 
Published: October 2021

Background: This study investigates the mediating effect of rumination on the associations between depressive symptoms and insomnia.Methods: This is a cross-sectional study. Insomnia Severity Index (ISI), Ruminant Response Scale (RRS) and Beck Depression Inventory (BDI) were determined in 12,178 college students in Qinghai province by a questionnaire network platform.Results: The prevalence of insomnia was 38.6% in the participants. Insomnia symptoms [interquartile range: 6 (3, 9)], depressive symptoms [interquartile range: 5 (1, 9)], and rumination [interquartile range: 22 (20, 26)] were positively correlated (r = 0.25–0.46, p &lt; 0.01). Mediation effect analysis showed that the depressive symptoms affected insomnia directly and indirectly. The direct effect and the indirect effect through rumination account for 92.4 and 7.6% of the total effect, respectively.Conclusion: The study shows that insomnia, depressive symptoms, and rumination are related constructs in college students in Qinghai province. It demonstrates the direct effects and the rumination-mediated indirect effects between depressive symptoms and insomnia; the direct effects seem to be dominant.
Point of Care Testing for Infectious Disease in Europe: A Scoping Review and Survey Study
Authors: Hocking Lucy , George Jenny , Broberg Eeva K. , Struelens Marc J. , Leitmeyer Katrin C. , Deshpande Advait , Parkinson Sarah , Francombe Joe , Morley Katherine I. , de Carvalho Gomes Helena 
Published: October 2021

Background: Point of care testing (POCT) for infectious diseases is testing conducted near the patient. It allows clinicians to offer the most appropriate treatment more quickly. As POCT devices have increased in accuracy and become more cost-effective, their use has grown, but a systematic assessment of their use for clinical and public health management of infectious diseases in EU/EEA countries has not been previously undertaken.Methods: A scoping review of the literature on POCT in EU/ EEA countries as at November 2019, and a survey of key stakeholders.Results: 350 relevant articles were identified and 54 survey responses from 26 EU/EEA countries were analysed. POCT is available for a range of infectious diseases and in all countries responding to the survey (for at least one disease). POCT is commonly available for influenza, HIV/AIDS, Legionnaires' disease and malaria, where it is used in at least half of EU/EEA countries. While POCT has the potential to support many improvements to clinical care of infectious diseases (e.g., faster diagnosis, more appropriate use of antimicrobials), the results suggest POCT is infrequently used to support public health functions (e.g., disease surveillance and reporting).Conclusion: Although POCT is in use to some extent in all EU/EEA countries, the full benefits of POCT in wider public health functions have yet to be realised. Further research on barriers and facilitators to implementation is warranted.
The COVID-19 Pandemic Impact on Away and Home Victories in Soccer and Rugby Union
Authors: Sedeaud Adrien , De Larochelambert Quentin , Schipman Julien , Toussaint Jean-Francois 
Published: October 2021

Objective: To measure the impact of restrictions due to COVID on the proportion of matches won at home, away and draw in professional soccer and rugby union.Materials and Methods: Two samples of professional soccer and rugby union matches were collected from 2012–13 to 2020–21 seasons. For soccer, data involved first and second division matches of the England, Spain, Germany, Italy, France, Belgium, Scotland, Greece, Portugal, and Turkey championships. For rugby union, championships concerned are Premiership Rugby, Celtic League, Top 14, and Pro D2. The proportions of home, away wins and draw were calculated and compared. A chi-square test of independence between years and types of result was realized to identify an overall inhomogeneity.Results: The proportion of away matches won between the 2012–13 and 2020–21 seasons increased significantly from 28.5 ± 1.2% to 32.5 ± 1.5% in soccer and from 38.0 ± 3.6% to 42.8 ± 5.0% in rugby union. In Premiership Rugby championship, the victory percentage at home dropped from 55.8 ± 3.1% when tifosi were present to 45.8 ± 12.8% when they were not.Conclusion: The home advantage was drastically reduced in empty stadiums for several European soccer and rugby union professional championships. It vanished in the Premiership Rugby and Celtic League during the 2020–21 season.
A Survey of Intestinal Helminths of Dogs in Slovakia with an Emphasis on Zoonotic Species
Authors: Jarošová Júlia , Antolová Daniela , Lukáč Branislav , Maďari Aladár 
Published: October 2021

Dogs are the most popular pets worldwide; however, close contact with people increases the risk of transmission of different zoonotic parasites. This study aims to determine the prevalence of gastrointestinal helminths in dogs in Slovakia. A total of 495 faecal samples collected from pet, shelter, guard, working (police), and hunting dogs, as well as dogs from segregated Roma settlements between 2016 and 2021, were examined using flotation and molecular methods. Eggs of intestinal helminths were detected in 134 (27.1%) samples. Microscopically, six different species/genera/families, namely, Toxocara canis (14.7%), Toxascaris leonina (1.6%), Trichuris vulpis (6.3%), Capillaria spp. (1.4%), Ancylostoma/Uncinaria spp. (8.3%), and taeniid eggs (4.0%), were recorded. Molecular analyses revealed infection with Echinococcus multilocularis in 2.2% of dogs and 0.4% of the animals were infected with Taenia hydatigena. The results showed a correlation between the occurrence of intestinal helminths and the availability of veterinary care, as dogs from Roma settlements and shelter dogs were the most often infected (66.7% and 39.2%, respectively). On the other hand, working animals were in the best health condition, with only 2.5% being positive. The relatively frequent occurrence of zoonotic species points to the constant need for preventive measures and regular deworming of dogs.
Spectroscopic and Structural Properties of β-Tricalcium Phosphates Ca9RE(PO4)7 (RE = Nd, Gd, Dy)
Authors: Paterlini Veronica , El Khouri Asmaa , Bettinelli Marco , Trucchi Daniele Maria , Capitelli Francesco 
Published: October 2021

Rare-earth-based Ca9RE(PO4)7 (RE = Nd, Gd, Dy) materials were synthesized by solid-state reaction at T = 1200 °C. The obtained tricalcium phosphate (TCP) materials are efficient light emitters due to the presence of RE3+ ions, although these ions are present at high concentrations. Moreover, in these host structures, these ions can be used as optical probes to study their local environments. Thus, photoluminescence (PL) emission spectra of the powder samples clearly indicated, for Dy3+ and Gd3+ ions, the presence of the RE3+ ion in low-symmetry sites with some local structural disorder, and the spectra show the presence of vibrational features (in the case of Gd3+). For the Nd3+ phase, emission bands are present around 900, 1050, and 1330 nm, originating from the 4F3/2 level. In general, these RE-TCP samples are interesting luminescent materials in the visible (Dy), UV (Gd), and NIR (Nd) regions, due to weak concentration quenching even for high concentrations of the emitting ion.
Brain Cancer Prediction Based on Novel Interpretable Ensemble Gene Selection Algorithm and Classifier
Authors: Almars Abdulqader M. , Alwateer Majed , Qaraad Mohammed , Amjad Souad , Fathi Hanaa , Kelany Ayda K. , Hussein Nazar K. , Elhosseini Mostafa 
Published: October 2021

The growth of abnormal cells in the brain causes human brain tumors. Identifying the type of tumor is crucial for the prognosis and treatment of the patient. Data from cancer microarrays typically include fewer samples with many gene expression levels as features, reflecting the curse of dimensionality and making classifying data from microarrays challenging. In most of the examined studies, cancer classification (Malignant and benign) accuracy was examined without disclosing biological information related to the classification process. A new approach was proposed to bridge the gap between cancer classification and the interpretation of the biological studies of the genes implicated in cancer. This study aims to develop a new hybrid model for cancer classification (by using feature selection mRMRe as a key step to improve the performance of classification methods and a distributed hyperparameter optimization for gradient boosting ensemble methods). To evaluate the proposed method, NB, RF, and SVM classifiers have been chosen. In terms of the AUC, sensitivity, and specificity, the optimized CatBoost classifier performed better than the optimized XGBoost in cross-validation 5, 6, 8, and 10. With an accuracy of 0.91±0.12, the optimized CatBoost classifier is more accurate than the CatBoost classifier without optimization, which is 0.81± 0.24. By using hybrid algorithms, SVM, RF, and NB automatically become more accurate. Furthermore, in terms of accuracy, SVM and RF (0.97±0.08) achieve equivalent and higher classification accuracy than NB (0.91±0.12). The findings of relevant biomedical studies confirm the findings of the selected genes.
Gastrodia elata Blume and Zanthoxylum schinifolium Siebold & Zucc Mixed Extract Suppress Platelet Aggregation and Thrombosis
Authors: Jeon Yong-Deok , Lee Ji-Hyun , Park Mi-Ran , Lim Ji-Ye , Kang Sa-Haeng , Kim Dae-Ki , Lee Young-Mi 
Published: October 2021

Background and objectives: Blood vessel thrombosis causes blood circulation disorders, leading to various diseases. Currently, various antiplatelet and anticoagulant drugs, such as aspirin, warfarin, heparin, and non-vitamin K antagonist oral anticoagulants (NOACs), are used as the major drugs for the treatment of a wide range of thrombosis. However, these drugs have a side effect of possibly causing internal bleeding due to poor hemostasis when taken for a long period of time. Materials and Methods: Gastrodia elata Blume (GE) and Zanthoxylum schinifolium Siebold & Zucc (ZS) are known to exhibit hemostatic and antiplatelet effects as traditional medicines that have been used for a long time. In this study, we investigated the effect of a mixed extract of GE and ZS (MJGE09) on platelet aggregation and plasma coagulation. Results: We found that MJGE09 inhibited collagen-and ADP-induced platelet aggregation in vitro. In addition, collagen- and ADP-induced platelet aggregation were also inhibited in a dose-dependent manner on the platelets of mice that were orally administered MJGE09 ex vivo. However, compared with aspirin, MJGE09 did not prolong the rat tail vein bleeding time in vivo and did not show a significant effect on the increase in the prothrombin time (PT) and activated partial thromboplastin time (aPTT). Conclusions: These results suggest that MJGE09 can be used as a potential anticoagulant with improved antithrombotic efficacy.
Identifying opportunities for timely diagnosis of bladder and renal cancer via abnormal blood tests: a longitudinal linked data study
Authors: Zhou Yin , Walter Fiona M , Mounce Luke , Abel Gary A , Singh Hardeep , Hamilton Willie , Stewart Grant D , Lyratzopoulos Georgios 
Published: October 2021

BackgroundUnderstanding pre-diagnostic test use could reveal diagnostic windows where more timely evaluation for cancer may be indicated.AimTo examine pre-diagnostic patterns of results of abnormal blood tests in patients with bladder and renal cancer.Design and settingA retrospective cohort study using primary care and cancer registry data on patients with bladder and renal cancer who were diagnosed between April 2012 and December 2015 in England.MethodThe rates of patients with a first abnormal result in the year before cancer diagnosis, for ‘generic’ (full blood count components, inflammatory markers, and calcium) and ‘organ-specific’ blood tests (creatinine and liver function test components) that may lead to subsequent detection of incidental cancers, were examined. Poisson regression was used to detect the month during which the cohort’s rate of each abnormal test started to increase from baseline. The proportion of patients with a test found in the first half of the diagnostic window was examined, as these ‘early’ tests might represent opportunities where further evaluation could be initiated.ResultsData from 4533 patients with bladder and renal cancer were analysed. The monthly rate of patients with a first abnormal test increased towards the time of cancer diagnosis. Abnormalities of both generic (for example, high inflammatory markers) and organ-specific tests (for example, high creatinine) started to increase from 6–8 months pre-diagnosis, with 25%–40% of these patients having an abnormal test in the ‘early half’ of the diagnostic window.ConclusionPopulation-level signals of bladder and renal cancer can be observed in abnormalities in commonly performed primary care blood tests up to 8 months before diagnosis, indicating the potential for earlier diagnosis in some patients.
Identifying multimorbidity clusters with the highest primary care use: 15 years of evidence from a multi-ethnic metropolitan population
Authors: Soley-Bori Marina , Bisquera Alessandra , Ashworth Mark , Wang Yanzhong , Durbaba Stevo , Dodhia Hiten , Fox-Rushby Julia 
Published: October 2021

BackgroundPeople with multimorbidity have complex healthcare needs. Some co-occurring diseases interact with each other to a larger extent than others and may have a different impact on primary care use.AimTo assess the association between multimorbidity clusters and primary care consultations over time.Design and settingA retrospective longitudinal (panel) study design was used. Data comprised electronic primary care health records of 826 166 patients registered at GP practices in an ethnically diverse, urban setting in London between 2005 and 2020.MethodPrimary care consultation rates were modelled using generalised estimating equations. Key controls included the total number of long-term conditions, five multimorbidity clusters, and their interaction effects, ethnic group, and polypharmacy (proxy for disease severity). Models were also calibrated by consultation type and ethnic group.ResultsIndividuals with multimorbidity used two to three times more primary care services than those without multimorbidity (incidence rate ratio 2.30, 95% confidence interval = 2.29 to 2.32). Patients in the alcohol dependence, substance dependence, and HIV cluster (Dependence+) had the highest rate of increase in primary care consultations as additional long-term conditions accumulated, followed by the mental health cluster (anxiety and depression). Differences by ethnic group were observed, with the largest impact in the chronic liver disease and viral hepatitis cluster for individuals of Black or Asian ethnicity.ConclusionThis study identified multimorbidity clusters with the highest primary care demand over time as additional long-term conditions developed, differentiating by consultation type and ethnicity. Targeting clinical practice to prevent multimorbidity progression for these groups may lessen future pressures on primary care demand by improving health outcomes.
FEATURES OF ORGANIZATION OF ACCESS IN AUTOMATED INFORMATION SYSTEMS BASED ON THE PRINCIPLES OF NONLINEAR DYNAMICS
Authors: Шевнина Ю.С. , Гагарина Л.Г. , Чирков А.В. , Миронов Н.С. 
Published: October 2021

Исследовано три решения проблематики нелинейного процесса организации доступа в АИС образовательного спектра. Определены ключевые причины появления затруднений с использованием автоматизированных информационных систем и проведен анализ существующих средств и методик, которые применяются при организации взаимодействия между пользователями и АИС. Статья объясняет, каким образом можно упростить доступ к АИС путем использования принципов декомпозиции и иерархичности. В реализации указано, какой может быть структура АИС типового образовательного учреждения. Проведено сравнение преимуществ и недостатков разных систем бухгалтерского, управленческого, хозяйственно-экономического учета с точки зрения интеграции в работу высших учебных заведений. Отдельное внимание уделено анализу механизмов и особенностей взаимодействия между подсистемами АИС и базой данных на примере проведения аттестационных мероприятий. На основании изученных аспектов функционирования АИС сделан вывод о недостаточности использования вузами локальных систем и необходимости разработки и последующей интеграции персонализированных высокотехнологичных решений, которые позволят увеличить эффективность образовательной деятельности. В перспективах показано, какие задачи можно поставить перед собой, чтобы внедрить дополнительные аспекты декомпозиции и иерархичности в аналогичных системах
We investigate three solutions to the problem of the nonlinear process of organizing access to the AIS of the educational spectrum. We identified the key reasons for the emergence of difficulties with the use of automated information systems and carried out the analysis of existing tools and techniques that are used in organizing interaction between users and AIS. We explained in what way we can simplify the access to AIS by using the principles of decomposition and hierarchy. The implementation indicates what the structure of the AIS of a typical educational institution can be. We carried out comparison of the advantages and disadvantages of different systems of accounting, managerial economic and economic accounting from the point of view of integration into the work of higher educational institutions. Special attention is paid to the analysis of the mechanisms and features of the interaction between the AIS subsystems and the database on the example of carrying out certification activities. On the basis of the studied aspects of the functioning of the AIS, we made a conclusion about the insufficient use of local systems by universities and the need for the development and subsequent integration of personalized high-tech solutions that will increase the efficiency of educational activities. The perspectives show what tasks you can set in order to implement additional aspects of decomposition and hierarchy in similar systems
OGLE-2019-BLG-0304: Competing Interpretations between a Planet–binary Model and a Binary-source + Binary-lens Model
Authors: Han Cheongho , Udalski Andrzej , Lee Chung-Uk , Kim Doeon , Ryu Yoon-Hyun ,   (Leading authors), Albrow Michael D. , Chung Sun-Ju , Gould Andrew , Hwang Kyu-Ha , Kil Jung Youn , Kim Hyoun-Woo , Shin In-Gu , Shvartzvald Yossi , Yee Jennifer C. , Zang Weicheng , Cha Sang-Mok , Kim Dong-Jin , Kim Seung-Lee , Lee Dong-Joo , Lee Yongseok , Park Byeong-Gon , Pogge Richard W. ,   (The KMTNet Collaboration), Mróz Przemek , Szymański Michał K. , Skowron Jan , Poleski Radosław , Soszyński Igor , Pietrukowicz Paweł , Kozłowski Szymon , Ulaczyk Krzysztof , Rybicki Krzysztof A. , Iwanek Patryk , Wrona Marcin , Gromadzki Mariusz ,   (The OGLE Collaboration)
Published: October 2021

Abstract
We analyze the microlensing event OGLE-2019-BLG-0304, whose light curve exhibits two distinctive features: a deviation in the peak region and a second bump appearing ∼61 days after the main peak. Although a binary-lens model can explain the overall features, it leaves subtle but noticeable residuals in the peak region. We find that the residuals can be explained by the presence of either a planetary companion located close to the primary of the binary lens (3L1S model) or an additional close companion to the source (2L2S model). Although the 3L1S model is favored over the 2L2S model, with Δχ
2 ∼ 8, securely resolving the degeneracy between the two models is difficult with the currently available photometric data. According to the 3L1S interpretation, the lens is a planetary system, in which a planet with a mass

0.51

−
0.23

+
0.51

M

J

is in an S-type orbit around a binary composed of stars with masses

0.27

−
0.12

+
0.27

M

⊙

and

0.10

−
0.04

+
0.10

M

⊙

. According to the 2L2S interpretation, however, the source is composed of G- and K-type giant stars and the lens is composed of a low-mass M dwarf and a brown dwarf with masses

0.12

−
0.05

+
0.12

M

⊙

and

0.045

−
.019

+
0.045

M

⊙

, respectively. The event illustrates the need for thorough model testing in the interpretation of lensing events with complex features in light curves.
The Star Formation History of a Post-starburst Galaxy Determined from Its Cluster Population
Authors: Chandar Rupali , Mok Angus , French K. Decker , Smercina Adam , Smith John-David T. 
Published: October 2021

Abstract
The recent star formation histories (SFHs) of post-starburst galaxies have been determined almost exclusively from detailed modeling of their composite starlight. This has provided important but limited information on the number, strength, and duration of bursts of star formation. In this work, we present a direct and independent measure of the recent SFH of the post-starburst galaxy S12 (plate-mjd-fiber for SDSS 623-52051-207; designated EAS12 in Smercina et al.) from its star cluster population. We detect clusters from high-resolution, UBR optical images taken with the Hubble Space Telescope and compare their luminosities and colors with stellar population models to estimate the ages and masses of the clusters. No clusters younger than ∼70 Myr are found, indicating star formation shut off at this time. Clusters formed ∼120 Myr ago reach masses up to a ∼few × 107
M
⊙, several times higher than similar-age counterparts formed in actively merging galaxies like the Antennae and NGC 3256. We develop a new calibration based on known properties for eight nearby galaxies to estimate the star formation rate (SFR) of a galaxy from the mass of the most massive cluster, M
max. The cluster population indicates that S12 experienced an extremely intense but short-lived burst ∼120 Myr ago, with an estimated peak of

500

−
250

+
500

M

⊙

yr

−
1

and duration of 50 ± 25 Myr, one of the highest SFRs estimated for any galaxy in the modern universe. The cluster population also allows us to fill in more of the backstory of S12. Prior to the recent, intense burst, S12 was forming stars at a moderate rate of ∼3–5 M
⊙ yr−1, typical of spiral galaxies, but the system experienced an earlier burst at some point, approximately 1–3 Gyr ago. While fairly uncertain, we estimate that the SFR during this earlier burst was ∼20–30 M
⊙ yr−1, similar to the current SFR in the Antennae and NGC 3256.