bluuebunny/crossref_metadata_2025_split huggingface dataset:
Training and resources of e-records readiness at the Federal Ministry of finance in Nigeria
Authors: Abdulkareem Mulikat Yetunde , Mnjama Nathan Mwakoshi , Sebina Peter Mazebe II Mothataesi 
Published: August 2021

Purpose
e-records have become an important tool through which a government is held accountable for good governance, transparency and delivery of services to citizens. Therefore, this study aims to assess availability of training and resources in a records management environment, as a way of determining e-records readiness at the Federal Ministry of Finance, Nigeria (FMFN).

Design/methodology/approach
Questionnaires and observation were used for data collection. Purposive and stratified sampling techniques were used. Quantitative data from the 250 usable questionnaires retrieved was analyzed using the Statistical Package for Social Sciences (SPSS), while qualitative data was analyzed manually.

Findings
The study findings revealed that FMFN has a records management unit with other resources such as a movable and lockable file cabinet, files, file holders, registers and computers. There is low budget allocation for records management activities. Training for records managers is infrequent. However, an orientation program for new staff exists. Employees prefer the following mode of training: seminars and workshops, internships and consultant-run training. In terms of kinds of training need, study participants noted that they require training on computer applications, e-records management and change management role of record management.

Research limitations/implications
This study is limited to employees of the Federal Ministry of Finance (FMF) in Abuja. As a result, the findings may not be generalized to other ministries in Nigeria.

Practical implications
It is hoped that the study would benefit the public sectors that are desirous to opt for e-records management and provide benchmarks for policymakers, particularly on how to maintain proper e-records readiness status through training and resources.

Originality/value
To the best of the authors’ knowledge, this is the first study to be conducted at FMFN on e-records readiness, more specifically on resources and training.
Automatic epileptic seizure detection using LSTM networks
Authors: Shekokar Kishori Sudhir , Dour Shweta 
Published: August 2021

Purpose
The purpose of this work is to make a computer aided detection system for epileptic seizures. Epilepsy is a neurological disorder characterized as the recurrence of two or more unprovoked seizures. The common and significant tool for aiding in the identification of epilepsy is Electroencephalography (EEG). The EEG signals contain information about the electrical activity of the brain. Conventionally, clinicians study the EEG waveforms manually to detect epileptic abnormalities, which is very time-consuming and error-prone.

Design/methodology/approach
The authors have presented a three-layer long short-term memory network for the detection of epileptic seizures.

Findings
The network classifies between seizure and non-seizure with 99.5% accuracy only in 30 epochs. This makes the proposed methodology useful for real-time seizure detection.

Originality/value
This research work is original and not plagiarized.
Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time
Authors: Belda Walter , Casolato Ana Thereza Stradioto , Luppi Juliana Bronzato , Passero Luiz Felipe Domingues 
Published: August 2021

AbstractChromoblastomycosis (CBM) is an infectious disease caused by fungi that is prevalent in tropical and subtropical countries. Besides few therapeutic options, the classical treatment of CBM needs to be administrated for a long period of time, and unfortunately some patients do not show improvement of the lesions. Thus, it becomes urgent to develop new strategies for the treatment of CBM. This work reports a successful treatment, performed with the combination of oral acitretin (50 mg/kg, once a day) plus topical imiquimod (50 mg/g, five times per week) for 5 months in a patient with CBM. A significant improvement of the lesions was observed in the 1st month, and in the 5th a complete regression of lesions was recorded. Changes in the biochemical parameters were not observed. These data suggest that the combination of acitretin and imiquimod may be effective at treating CBM.
Association between cheilitis granulomatosa and odontogenic infections: A case–control study
Authors: Hu Xiaosheng , Xing Yixiao , Mu Changqing , Liu Yang , Hua Hong 
Published: August 2021

AbstractThe association between cheilitis granulomatosa and dental infections (dental caries and apical periodontitis) is still not well understood. Herein, we aimed to investigate the association in large hospital cases with cohort controls. Cheilitis granulomatosa cases (n = 181) were retrieved from Peking University Hospital of Stomatology and age‐ and sex‐matched to controls (n = 181). The χ2‐test, Student’s t‐test, and Mann–Whitney U‐test were used to compare the differences between groups. The χ2‐test and odds ratio were used to verify if there was an association and risk relationship. The results showed that both dental caries and apical periodontitis were associated with cheilitis granulomatosa (p < 0.001). Individuals with cheilitis granulomatosa had approximately a twofold increased frequency of dental caries than those without cheilitis granulomatosa (104/181, 57.5% vs. 53/181, 29.3%) (p < 0.001). The odds ratio of dental caries occurring in the case group compared to the control group was 3.211. The frequency of apical periodontitis in patients with cheilitis granulomatosa was significantly greater than in those without cheilitis granulomatosa (109/181, 60.2% vs. 28/181, 15.5%) (p < 0.001). The odds ratio was 8.272. Moreover, apical periodontitis was also locationally related to cheilitis granulomatosa (p < 0.001). Collectively, our study showed that the foci of dental infections are associated with cheilitis granulomatosa, suggesting that proper treatment of focal teeth may be important in the management of cheilitis granulomatosa.
Multiscale phase inversion for vertical transverse isotropic media
Authors: Feng Shihang , Fu Lei , Feng Zongcai , Schuster Gerard T. 
Published: August 2021

ABSTRACTInanisotropy full waveform inversion, the pseudo‐acoustic approximation is widely used to reduce the computation cost. However, artefacts and inaccurate predictions of amplitudes by the pseudo‐acoustic approximation often result in slow convergence in the full waveform inversion iterations and inaccurate tomograms. To solve this problem, multiscale phase inversion methodology is extended to vertical transverse isotropic media. In multiscale phase inversion, the amplitude spectra of the predicted data are replaced by those of the recorded data to mitigate the amplitude mismatch problem. Moreover, multiscale phase inversion tends to avoid the local minimum problem of full waveform inversion by temporally integrating the traces several times. Numerical tests on synthetic data and field data demonstrate the superiority of this method compared to conventional multiscale full waveform inversion for vertical transverse isotropic media.
Facilitation by isolated trees triggers woody encroachment and a biome shift at the savanna–forest transition
Authors: Abreu Rodolfo C. R. , Durigan Giselda , Melo Antônio C. G. , Pilon Natashi A. L. , Hoffmann William A. 
Published: August 2021

Abstract

Woody encroachment into grassy biomes is a global phenomenon, often resulting in a nearly complete turnover of species, with savanna specialists being replaced by forest‐adapted species. Understanding the mechanisms involved in this change is important for devising strategies for managing savannas.

We examined how isolated trees favour woody encroachment and species turnover by overcoming dispersal limitation and environmental filtering. In a savanna released from fire in south‐eastern Brazil (Cerrado), we sampled woody plants establishing under 40 tree canopies and in paired treeless plots. These trees comprised eight species selected for habitat preference (savanna or forest) and dispersal syndrome (bird dispersed or not). We recorded dimensions of each tree, dispersal syndrome and habitat preference of recruits, and quantified the physical environment within each plot, aiming at a mechanistic understanding of woody encroachment.

We found clear evidence that isolated trees cause nucleation and drive changes in functional composition of savanna. Effectiveness as nucleator differed among species, but was unrelated to their functional guilds (habitat preference or dispersal syndrome). The density of saplings in nuclei was partially explained by soil moisture (+), daily temperature amplitude (−) and sum of bases (−).

Our results indicate that isolated trees act first as perches, strongly favouring bird‐dispersed species. They then act as nurse trees, considerably changing the environment in favour of forest‐adapted recruits. In the long term, as the nuclei expand and merge, savanna specialists tend to disappear and the savanna turns into a low‐diversity forest.

Synthesis and applications. Fire suppression has allowed the nucleation process and consequently the woody encroachment and fast replacement of savanna specialists by forest species in the Cerrado. By elucidating the mechanisms behind woody encroachment, we recommend using prescribed fires to burn forest seedlings and to reduce tree canopy size wherever the management goal is to maintain the typical savanna structure and composition.
Dapagliflozin and xanthine oxidase inhibitors improve insulin resistance and modulate renal glucose and urate transport in metabolic syndrome
Authors: Ng Hwee‐Yeong , Leung Foong‐Fah , Kuo Wei‐Hung , Lee Wen‐Chin , Lee Chien‐Te 
Published: August 2021

AbstractDisturbance in glucose and uric acid metabolism is the major disorder of metabolic syndrome (MetS). The kidneys play an important role in the management of glucose and uric acid. The aim of our study was to investigate alterations in renal glucose and uric acid transporters in animals with MetS after treatment with dapagliflozin and xanthine oxidase inhibitors (allopurinol and febuxostat). Sprague–Dawley rats were fed normal chow or a high fructose diet for the first 3 months. The fructose‐fed animals were then treated with dapagliflozin, allopurinol, febuxostat, or no treatment for the next 3 months. Fasting glucose, insulin resistance, and hyperuricaemia were improved in all treatment groups except that in the fructose group (all p < 0.05). Both allopurinol and febuxostat reversed the increase in levels of sodium glucose cotransporter (SGLT) 1, SGLT2, and glucose transporter (GLUT) 2 (all p < 0.05). Dapagliflozin alleviated hyperuricaemia and induced uricosuria without affecting serum xanthine oxidase activity. Dapagliflozin suppressed the expression of GLUT9, urate transporter, and urate anion exchanger 1 (all p < 0.05), which was similar to the effects of allopurinol and febuxostat. The results suggest that treatment with dapagliflozin and xanthine oxidase inhibitors improved insulin resistance and reversed the increased expression of glucose and urate transporters in the kidney.
Precipitation increases the abundance of fungal plant pathogens in Eucalyptus phyllosphere
Authors: Chen Qing‐Lin , Hu Hang‐Wei , Yan Zhen‐Zhen , Li Chao‐Yu , Nguyen Bao‐Anh Thi , Zhu Yong‐Guan , He Ji‐Zheng 
Published: August 2021

SummaryUnderstanding the current and future distributions of plant pathogens is critical to predict the plant performance and related economic benefits in the changing environment. Yet, little is known about the roles of environmental drivers in shaping the profiles of fungal plant pathogens in phyllosphere, an important habitat of microbiomes on Earth. Here, using a large‐scale investigation of Eucalyptus phyllospheric microbiomes in Australia and the multiple linear regression model, we show that precipitation is the most important predictor of fungal taxonomic diversity and abundance. The abundance of fungal plant pathogens in phyllosphere exhibited a positive linear relationship with precipitation. With this empirical dataset, we constructed current and future atlases of phyllosphere plant pathogens to estimate their spatial distributions under different climate change scenarios. Our atlases indicate that the abundance of fungal plant pathogens would increase especially in the coastal regions with up to 100‐fold increase compared with the current abundance. These findings advance our understanding of the distributions of fungal plant pathogens in phyllospheric microbiomes under the climate change, which can improve our ability to predict and mitigate their impacts on plant productivity and economic losses.
Open Dialogue trainees’ expectations of ‘shared concern’: An international focus group study
Authors: Buus Niels , Leer Mie , Mikes‐Liu Kristof , Dawson Lisa , Folkmann Pedersen Merete , Einboden Rochelle , McCloughen Andrea 
Published: August 2021

AbstractOpen Dialogue is an alternative approach to service provision for people experiencing mental health problems. Training and implementation of dialogical ways of working require that professionals disposition themselves as experts and ‘unlearn’ traditional therapeutic relations. This study explored trainees’ discussions of their expectations of Open Dialogue as they commence their training. Four focus groups, two in Australia and two in Denmark, were analysed thematically. We generated the theme ‘shared concern’ with four sub‐themes: (1) ‘A democratising alternative’, (2) ‘Waiting and listening’, (3) ‘Acknowledging many kinds of expertise’ and (4) ‘Personal participation’. Rather than learning a therapeutic technique, ‘shared concern’ in dialogical practices emphasised a collaborative approach to manage ubiquitous uncertainty and a political commitment to addressing inequities in service delivery. This variance from usual reasons to undertake training has implications for course design and delivery that have yet to be considered.Practitioner points

The theme ‘shared concern’ was generated from across the focus groups, which was well aligned with the doxa of Open Dialogue

Trainees emphasised their experience of Open Dialogue as a moral counterapproach to traditional healthcare with less emphasis on the actual psychotherapeutic practices
Fast and reliable analysis of veterinary metomidate and etomidate in human blood samples by liquid chromatography–tandem mass spectrometry (LC–MS/MS) in a postmortem case
Authors: Yum Hyesun , Jeong Sujin , Jang Moonhee , Moon Sungmin , Kang Minji , Kim Byungjoo , Kim Dongwoo , Choe Sanggil , Yang Wonkyung , Kim Jihyun , Han Sang Beom 
Published: August 2021

AbstractMetomidate and etomidate belong to the non‐barbiturate imidazole family of sedative–hypnotics and elicit little analgesic action when used alone. Metomidate, in particular, has little analgesic activity in humans and is, therefore, used for veterinary purposes. In 2019, a Korean woman in her twenties was found unconscious in a motel bath and eventually died. Etomidate, alprazolam, escitalopram, and metomidate were detected in the postmortem specimens. To our knowledge, this is the first case of human metomidate abuse reported in the Republic of Korea. In this research, a simple and reliable method was developed for the analysis of metomidate and etomidate in human blood samples using liquid chromatography–tandem mass spectrometry (LC–MS/MS). Blood samples were deproteinized with acetonitrile, filtered, and analyzed by LC–MS/MS. Linear calibration curves were obtained with six concentrations ranging from 1 to 50 ng/ml for metomidate and 10 to 500 ng/ml for etomidate. The method was validated by assessing the selectivity, linearity, limit of detection (LOD), limit of quantitation (LOQ), intra‐ and inter‐day precision and accuracy, matrix effect, and stability and successfully applied to the analysis of metomidate and etomidate in human blood samples. In a postmortem case, the concentrations of metomidate and etomidate were found to be 8 and 110 ng/ml in femoral blood and 6 and 210 ng/ml in cardiac blood, respectively.
A systematic review of quantitative analysis of cannabinoids in oral fluid
Authors: Gorziza Roberta Petry , Duarte Jonathaline Apollo , González Marina , Arroyo‐Mora Luis E. , Limberger Renata Pereira 
Published: August 2021

AbstractCannabis sativa L. is a substance widely used around the world for recreational and medicinal purposes. Oral fluid has been investigated as an alternative biological matrix for demonstrating the illegal use of cannabis, particularly in situations where its recent use needs to be identified. In the last two decades, many methods have been developed to detect and quantify cannabinoids in oral fluid, especially for Δ9‐tetrahydrocannabinol, the primary psychoactive substance of cannabis. However, some aspects must be considered in the use of these techniques, such as cannabinoids recoveries or extraction efficiency from different oral fluid collection devices/containers. Pharmacokinetic studies have shown that the presence of minor cannabinoids and metabolites in the analysis of oral fluid may be valuable in interpreting tests, which indicates the need to improve the sensitivity of detecting low concentrations. The aim of this review is to summarize and to describe the methodologies for the quantitative analysis of cannabinoids in oral fluid that have previously been investigated. A systematic search for articles was performed of four different databases, using the descriptor “cannabinoids and oral fluid”. Forty‐seven studies that examined quantitative methods were identified. The analytical data described in these articles, including oral fluid collection, sample preparation, cannabinoids recovery and extraction efficiency, detection instruments, and quantification limits, were analyzed. The discussion of these particular features of cannabinoid analysis in oral fluid could help to improve or to develop methods for use in Forensic Toxicology.
DisCoTune: versatile auxiliary plasmids for the production of disulphide‐containing proteins and peptides in the E. coli T7 system
Authors: Bertelsen Andreas B. , Hackney Celeste Menuet , Bayer Carolyn N. , Kjelgaard Lau D. , Rennig Maja , Christensen Brian , Sørensen Esben Skipper , Safavi‐Hemami Helena , Wulff Tune , Ellgaard Lars , Nørholm Morten H. H. 
Published: August 2021

SummarySecreted proteins and peptides hold large potential both as therapeutics and as enzyme catalysts in biotechnology. The high stability of many secreted proteins helps maintain functional integrity in changing chemical environments and is a contributing factor to their commercial potential. Disulphide bonds constitute an important post‐translational modification that stabilizes many of these proteins and thus preserves the active state under chemically stressful conditions. Despite their importance, the discovery and applications within this group of proteins and peptides are limited by the availability of synthetic biology tools and heterologous production systems that allow for efficient formation of disulphide bonds. Here, we refine the design of two DisCoTune (Disulphide bond formation in E. coli with tunable expression) plasmids that enable the formation of disulphides in the highly popular Escherichia coli T7 protein production system. We show that this new system promotes significantly higher yield and activity of an industrial protease and a conotoxin, which belongs to a group of disulphide‐rich venom peptides from cone snails with strong potential as research tools and pharmacological agents.
Use of crizotinib as neoadjuvant therapy for non‐small cell lung cancers patient with ROS1 rearrangement: A case report
Authors: Zhao Shikang , Zhu Shuai , Lei Xi , Xu Dongbo , Shi Tao , Chen Qiusong , Ren Fan , Chen Gang , Huang Dingzhi , Xu Song 
Published: August 2021

AbstractCrizotinib showed significant antitumor effect in patients with advanced ROS1‐rearranged non‐small cell lung cancers (NSCLC). Most recently, many studies have explored the feasibility and efficacy of target therapy for perioperative application in NSCLC. Here, we describe a female patient who was diagnosed with stage IIIB lung adenocarcinoma exhibiting a CCDC6‐ROS1 rearrangement by high‐throughput sequencing. The tumor and lymph nodes showed durable response after the treatment of crizotinib. Given that a radiological downstaging was indicated, a right lower lobectomy and systemic lymphadenectomy were successfully performed. The pathological response was 60% and the tumor, nodes, and metastases (TNM) stage was ypT2bN0M0. The PD‐L1 expression and activity of immunological cells were also investigated.
Molecular mimicry between SARS‐CoV‐2 and the female reproductive system
Authors: Dotan Arad , Kanduc Darja , Muller Sylviane , Makatsariya Alexander , Shoenfeld Yehuda 
Published: August 2021

AbstractIntroductionOogenesis, the process of egg production by the ovary, involves a complex differentiation program leading to the production of functional oocytes. This process comprises a sequential pathway of steps that are finely regulated. The question related to SARS‐CoV‐2 infection and fertility has been evoked for several reasons, including the mechanism of molecular mimicry, which may contribute to female infertility by leading to the generation of deleterious autoantibodies, possibly contributing to the onset of an autoimmune disease in infected patients.ObjectiveThe immunological potential of the peptides shared between SARS‐CoV‐2 spike glycoprotein and oogenesis‐related proteins; Thus we planned a systematic study to improve our understanding of the possible effects of SARS‐CoV‐2 infection on female fertility using the angle of molecular mimicry as a starting point.MethodsA library of 82 human proteins linked to oogenesis was assembled at random from UniProtKB database using oogenesis, uterine receptivity, decidualization, and placentation as a key words. For the analyses, an artificial polyprotein was built by joining the 82 a sequences of the oogenesis‐associated proteins. These were analyzed by searching the Immune Epitope DataBase for immunoreactive SARS‐CoV‐2 spike glycoprotein epitopes hosting the shared pentapeptides.ResultsSARS‐CoV‐2 spike glycoprotein was found to share 41 minimal immune determinants, that is, pentapeptides, with 27 human proteins that relate to oogenesis, uterine receptivity, decidualization, and placentation. All the shared pentapeptides that we identified, with the exception of four, are also present in SARS‐CoV‐2 spike glycoprotein–derived epitopes that have been experimentally validated as immunoreactive.
Blurred Lines: Intersections of Ethnography and Rape in South Africa and Mozambique
Authors: Connor Teresa K. 
Published: August 2021

SummaryIn this article, I examine the blurred lines between my own experience of violence in South Africa and that of the women I encountered while doing fieldwork in Pafuri, Mozambique. I centralize the importance of personal insight to deal with violent sexuality and rape and argue that reflection provides meaning to the process of ethnographic fieldwork. I examine the similarities between my own experience of violence in South Africa and that of my interlocutors in Mozambique, set within a regional political system that marginalizes women's experiences in both countries. While negative experiences of rape stem from a prejudiced history, I argue that these experiences can be overcome through rebirth or initiation. In my case, this was achieved through the personal level of transformation that fieldwork produced, while for women in Pafuri, the initiation (vukhomba) of young girls translates violence into empowerment.