bluuebunny/crossref_metadata_2025_split huggingface dataset:
Widespread Megaripple Activity Across the North Polar Ergs of Mars
Authors: Chojnacki Matthew , Vaz David A. , Silvestro Simone , Silva David C. A. 
Published: November 2021

AbstractThe most expansive dune fields on Mars surround the northern polar cap where various aeolian bedform classes are modified by wind and ice. The morphology and dynamics of these ripples, intermediate‐scale bedforms (termed megaripples and Transverse Aeolian Ridges [TARs]), and sand dunes reflect information regarding regional boundary conditions. We found that populations of polar megaripples and larger TARs are distinct in terms of their morphology, spatial distribution, and mobility. Whereas regionally restricted TARs appeared degraded and static in long‐baseline observations, polar megaripples were not only widespread but migrating at relatively high rates (0.13 ± 0.03 m/Earth year) and possibly more active than other regions on Mars. This high level of activity is somewhat surprising since there is limited seasonality for aeolian transport due to surficial frost and ice during the latter half of the martian year. A comprehensive analysis of an Olympia Cavi dune field estimated that the advancement of megaripples, ripples, and dunes avalanches accounted for ∼1%, ∼10%, and ∼100%, respectively, of the total aeolian system's sand fluxes. This included dark‐toned ripples that migrated the average equivalent of 9.6 ± 6 m/yr over just 22 days in northern summer—unprecedented rates for Mars. While bedform transport rates are some of the highest yet reported on Mars, the sand flux contribution between the different bedforms does not substantially vary from equatorial sites with lower rates. Seasonal off‐cap sublimation winds and summer‐time polar storms are attributed as the cause for the elevated activity, rather than cryospheric processes.
Annual Tropical‐Rainforest Productivity Through Two Decades: Complex Responses to Climatic Factors, [CO2] and Storm Damage
Authors: Clark Deborah A. , Clark David B. , Oberbauer Steven F. 
Published: November 2021

AbstractYearly changes in tropical carbon‐cycling have been a major biotic determinant of the interannual variation in the rise of atmospheric carbon dioxide ([CO2]). The environmental responses underlying these changes remain poorly understood. A 21‐year field study (1997–2018) in a Costa Rican rainforest has produced the first multi‐decade record of landscape‐scale annual aboveground productivity for a tropical ecosystem. While none of the four production components (wood production; leaf‐, twig‐, and reproductive litterfall) increased over two decades, all significantly varied among years. Multi‐factor environmental models explained a large fraction of the inter‐year changes in two production components. Annual changes in three climatic factors and [CO2] jointly accounted for 84% of the variation in annual wood production. While the strongest response of wood production was to decline in years of slightly warmer nights, it also significantly declined in years with more dry‐season hours hotter than 28°C. The yearly changes in reproductive litterfall were largely (52%) determined by the combined effects of increasing [CO2] and declining annual radiation. Twig litterfall declined over the 21 years. Annual leaf litterfall, the largest component of field‐assessed aboveground production, showed no significant environmental responses. An extreme storm in the study's final year disrupted the environmental controls on production that prevailed through the prior 20 years. While important uncertainties are introduced by some of the field methods for assessing aboveground forest production, the findings of this first long‐term field study of annual landscape‐scale productivity raise deep concerns for the future of tropical forests as global warming proceeds.
MHD‐Test Particles Simulations of Moderate CME and CIR‐Driven Geomagnetic Storms at Solar Minimum
Authors: Hudson Mary K. , Elkington Scot R. , Li Zhao , Patel Maulik , Pham Kevin , Sorathia Kareem , Boyd Alex , Jaynes Allison , Leali Alexis 
Published: November 2021

AbstractAs part of the Whole Heliosphere and Planetary Interactions initiative, contrasting drivers of radiation belt electron response at solar minimum have been investigated with MHD‐test particle simulations for the May 13–14, 2019 Coronal Mass Ejection (CME)‐shock event and the August 30–September 3, 2019 high speed solar wind interval. Both solar wind drivers produced moderate geomagnetic storms characterized by a minimum Dst = −65 nT and −52 nT, respectively, with the August ‐ September event accompanied by prolonged substorm activity. The latter, with characteristic features of a Corotating Interaction Region (CIR)‐driven storm, produced the hardest relativistic electron spectrum observed by Van Allen Probes during the last two years of the mission, ending in October 2019. MHD simulations were performed using both the Lyon‐Fedder‐Mobarry global MHD code and recently developed GAMERA model coupled to the Rice Convection Model, run with measured L1 solar wind input for both events studied, and coupled with test particle simulations, including an initial trapped and injected population. Initial electron Phase Space Density (PSD) profiles used measurements from the Relativistic Electron Proton Telescope and MagEIS energetic particle instruments on Van Allen Probes for test particle weighting and updating of the injected population at apogee. Results were compared directly with measurements and found to reproduce magnetopause loss for the CME‐shock event and increased PSD for the CIR event. The two classes of events are contrasted for their impact on outer zone relativistic electrons near the end of Solar Cycle 24.
Epigenome-wide association study of alcohol use disorder in five brain regions
Authors: Zillich Lea , Frank Josef , Streit Fabian , Friske Marion M. , Foo Jerome C. , Sirignano Lea , Heilmann-Heimbach Stefanie , Dukal Helene , Degenhardt Franziska , Hoffmann Per , Hansson Anita C. , Nöthen Markus M. , Rietschel Marcella , Spanagel Rainer , Witt Stephanie H. 
Published: November 2021

AbstractAlcohol use disorder (AUD) is closely linked to the brain regions forming the neurocircuitry of addiction. Postmortem human brain tissue enables the direct study of the molecular pathomechanisms of AUD. This study aims to identify these mechanisms by examining differential DNA-methylation between cases with severe AUD (n = 53) and controls (n = 58) using a brain-region-specific approach, in which sample sizes ranged between 46 and 94. Samples of the anterior cingulate cortex (ACC), Brodmann Area 9 (BA9), caudate nucleus (CN), ventral striatum (VS), and putamen (PUT) were investigated. DNA-methylation levels were determined using the Illumina HumanMethylationEPIC Beadchip. Epigenome-wide association analyses were carried out to identify differentially methylated CpG-sites and regions between cases and controls in each brain region. Weighted correlation network analysis (WGCNA), gene-set, and GWAS-enrichment analyses were performed. Two differentially methylated CpG-sites were associated with AUD in the CN, and 18 in VS (q < 0.05). No epigenome-wide significant CpG-sites were found in BA9, ACC, or PUT. Differentially methylated regions associated with AUD case-/control status (q < 0.05) were found in the CN (n = 6), VS (n = 18), and ACC (n = 1). In the VS, the WGCNA-module showing the strongest association with AUD was enriched for immune-related pathways. This study is the first to analyze methylation differences between AUD cases and controls in multiple brain regions and consists of the largest sample to date. Several novel CpG-sites and regions implicated in AUD were identified, providing a first basis to explore epigenetic correlates of AUD.
The gut microbiome of extremely preterm infants randomized to the early progression of enteral feeding
Authors: Salas Ariel A. , Willis Kent A. , Carlo Waldemar A. , Yi Nengjun , Zhang Li , Van Der Pol William J. , Younge Noelle E. , Lefkowitz Elliot J. , Lal Charitharth V. 
Published: November 2021

AbstractBackgroundEarly progression of feeding could influence the development of the gut microbiome.MethodsWe collected fecal samples from extremely preterm infants randomized to receive either early (feeding day 2) or delayed (feeding day 5) feeding progression. After study completion, we compared samples obtained at three different time points (week 1, week 2, and week 3) to determine longitudinal differences in specific taxa between the study groups using unadjusted and adjusted negative binomial and zero-inflated mixed models. Analyses were adjusted for a mode of delivery, breastmilk intake, and exposure to antibiotics.ResultsWe analyzed 137 fecal samples from 51 infants. In unadjusted and adjusted analyses, we did not observe an early transition to higher microbial diversity within samples (i.e., alpha diversity) or significant differences in microbial diversity between samples (i.e., beta diversity) in the early feeding group. Our longitudinal, single-taxon analysis found consistent differences in the generaLactococcus,Veillonella, andBilophilabetween groups.ConclusionsDifferences in single-taxon analyses independent of the mode of delivery, exposure to antibiotics, and breastmilk feeding suggest potential benefits of early progression of enteral feeding volumes. However, this dietary intervention does not appear to increase the diversity of the gut microbiome in the first 28 days after birth.Trial RegistrationClinicalTrials.gov identifier: NCT02915549.ImpactEarly progression of enteral feeding volumes with human milk reduces the duration of parenteral nutrition and the need for central venous access among extremely preterm infants.Early progression of enteral feeding leads to single-taxon differences in longitudinal analyses of the gut microbiome, but it does not appear to increase the diversity of the gut microbiome in the first 28 days after birth.Randomization in enteral feeding trials creates appealing opportunities to evaluate the effects of human milk diets on the gut microbiome.
Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk
Authors: De Angelis Flavio , Wendt Frank R. , Pathak Gita A. , Tylee Daniel S. , Goswami Aranyak , Gelernter Joel , Polimanti Renato 
Published: November 2021

AbstractAlcohol drinking and tobacco smoking are hazardous behaviors associated with a wide range of adverse health outcomes. In this study, we explored the association of polygenic risk scores (PRS) related to drinks per week, age of smoking initiation, smoking initiation, cigarettes per day, and smoking cessation with 433 psychiatric and behavioral traits in 4498 children and young adults (aged 8–21) of European ancestry from the Philadelphia neurodevelopmental cohort. After applying a false discovery rate multiple testing correction accounting for the number of PRS and traits tested, we identified 36 associations related to psychotic symptoms, emotion and age recognition social competencies, verbal reasoning, anxiety-related traits, parents’ education, and substance use. These associations were independent of the genetic correlations among the alcohol-drinking and tobacco-smoking traits and those with cognitive performance, educational attainment, risk-taking behaviors, and psychopathology. The removal of participants endorsing substance use did not affect the associations of each PRS with psychiatric and behavioral traits identified as significant in the discovery analyses. Gene-ontology enrichment analyses identified several neurobiological processes underlying mechanisms of the PRS associations we report. In conclusion, we provide novel insights into the genetic overlap of smoking and drinking behaviors in children and young adults, highlighting their independence from psychopathology and substance use.
Secure attachment priming protects against relapse of fear in Young adults
Authors: Toumbelekis Metaxia , Liddell Belinda J. , Bryant Richard A. 
Published: November 2021

AbstractPrevious studies have shown that activating the attachment system attenuates fear learning. This study aimed to explore whether attachment priming can also impact on fear extinction processes, which underpin the management of anxiety disorders. In this study, 81 participants underwent a standard fear conditioning and extinction protocol on day 1 and returned 24 h later for an extinction recall and reinstatement test. Half the participants were primed to imagine their closest attachment figure prior to undergoing extinction training, while the other half were instructed to imagine a positive situation. Fear-potentiated startle and subjective expectancies of shock were measured as the primary indicators of fear. Attachment priming led to less relapse during the reinstatement test at the physiological but not subjective levels. These findings have translational potential to imply that activating awareness of attachment figures might augment long-term safety memories acquired in existing treatments to reduce relapse of fear.
Single-cell RNA-seq highlights a specific carcinoembryonic cluster in ovarian cancer
Authors: Zhao Hongyu , Gao Yan , Miao Jinwei , Chen Suwen , Li Jie , Li Zhefeng , Yin Chenghong , Yue Wentao 
Published: November 2021

AbstractExpounding the heterogeneity for ovarian cancer (OC) with the cognition in developmental biology might be helpful to search for robust prognostic markers and effective treatments. In the present study, we employed single-cell RNA-seq with ovarian cancers, normal ovary, and embryo tissue to explore their heterogeneity. Then the differentiation process of clusters was explored; the pivotal cluster and markers were identified. Furthermore, the consensus clustering algorithm was used to explore the different clinical phenotypes in OC. At last, a prognostic model was construct and used to assess the prognosis for OCs. As a result, eight diverse clusters were identified, and the similarity existed in some clusters between embryo and tumours based on their gene expression. Meaningfully, a subtype of malignant epithelial cluster, PEG10+ EME, was associated with poor survival and was an intermediate stage of embryo to tumour. PEG10 was a CSC marker and might influence CSC self-renewal and promote cisplatin resistance via NOTCH pathway. Utilising specific gene profiles of PEG10+ EME based on public data sets, four phenotypes with different survival and clinical response to anti-PD-1/PD-L1 immunotherapy were identified. These insights allowed for the investigation of single-cell transcriptome of OCs and embryo, which advanced our current understanding of OC pathogenesis and resulted in promising therapeutic strategies.
CircESRP1 inhibits clear cell renal cell carcinoma progression through the CTCF-mediated positive feedback loop
Authors: Gong Lin-Jing , Wang Xin-Yuan , Yao Xu-dong , Wu Xu , Gu Wen-Yu 
Published: November 2021

AbstractCircular RNA (circRNA), a closed continuous loop formed by back-splicing, has been confirmed to be implicated in a variety of human diseases including cancers. However, the underlying molecular mechanism of circRNA regulating the progression of renal cell carcinoma (RCC) remains largely unclear. In the present study, we identified a novel circular RNA, circESRP1, that derived from the ESRP1 gene locus at 8q22.1 exons. Lower expression of circESRP1 was found in clear cell RCC (ccRCC) tissues and cell lines. Besides, circESRP1 expression level showed inversely correlated with the advanced tumor size, TNM stage and distant metastasis of ccRCC. The expression level of circESRP1 exhibited a positive correlation with CTCF protein but negatively correlated with miR-3942 in 79 ccRCC tissues. In vivo experiments, we found that overexpression of circESRP1 effectively repressed xenograft tumor growth and inhibited c-Myc-mediated EMT progression. CircESRP1 acted as a sponge to competitively bind with miR-3942 as confirmed through RNA pull-down, RIP and dual-luciferase reporter assays. Moreover, CTCF, a downstream target of miR-3942, was validated to specifically promote the circESRP1 transcript expression and regulated by circESRP1/miR-3942 pathway to form a positive feedback loop. We also revealed that the circESRP1/miR-3942/CTCF feedback loop regulated the ccRCC cell functions via c-Myc mediated EMT process. This study provides a novel regulatory model of circRNA via forming a positive-feedback loop that perpetuates the circESRP1/miR-3942/CTCF axis, suggesting that this signaling may serve as a novel target for the treatment of ccRCC.
Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer
Authors: Yang Jiawen , Mo Jiajie , Dai Juji , Ye Chenqiao , Cen Wei , Zheng Xuzhi , Jiang Lei , Ye Lechi 
Published: November 2021

AbstractCetuximab is approved for the treatment of metastatic colorectal cancer (mCRC) with RAS wild-type. Nevertheless, the prognosis remains poor and the effectiveness of cetuximab is limited in KRAS mutant mCRC. Recently, emerging evidence has shown that ferroptosis, a newly discovered form of nonapoptotic cell death, is closely related to KRAS mutant cells. Here, we further investigated whether cetuximab-mediated regulation of p38/Nrf2/HO-1 promotes RSL3-induced ferroptosis and plays a pivotal role in overcoming drug resistance in KRAS mutant colorectal cancer (CRC). In our research, we used two KRAS mutant CRC cell lines, HCT116 and DLD-1, as models of intrinsic resistance to cetuximab. The viability of cells treated with the combination of RSL3 and cetuximab was assessed by the CCK-8 and colony formation assays. The effective of cetuximab to promote RSL3-induced ferroptosis was investigated by evaluating lipid reactive oxygen species accumulation and the expression of the malondialdehyde and the intracellular iron assay. Cetuximab therapy contributed to regulating the p38/Nrf2/HO-1 axis, as determined by western blotting and transfection with small interfering RNAs. Cetuximab promoted RSL3-induced ferroptosis by inhibiting the Nrf2/HO-1 in KRAS mutant CRC cells, and this was further demonstrated in a xenograft nude mouse model. Our work reveals that cetuximab enhances the cytotoxic effect of RSL3 on KRAS mutant CRC cells and that cetuximab enhances RSL3-induced ferroptosis by inhibiting the Nrf2/HO-1 axis through the activation of p38 MAPK.
Lipidomics reveals that sustained SREBP-1-dependent lipogenesis is a key mediator of gefitinib-acquired resistance in EGFR-mutant lung cancer
Authors: Xu Chuncao , Zhang Lei , Wang Daifei , Jiang Shiqin , Cao Di , Zhao Zhongxiang , Huang Min , Jin Jing 
Published: November 2021

AbstractPatients with EGFR mutations in non-small cell lung cancer (NSCLC) have been greatly benefited from gefitinib, however, the therapeutic has failed due to the presence of acquired resistance. In this study, we show that gefitinib significantly induces downregulation of Sterol Regulator Element Binding (SREBP1) in therapy-sensitive cells. However, this was not observed in EGFR mutant NSCLC cells with acquired resistance. Lipidomics analysis showed that gefitinib could differently change the proportion of saturated phospholipids and unsaturated phospholipids in gefitinib-sensitive and acquired-resistant cells. Besides, levels of ROS and MDA were increased upon SREBP1 inhibition and even more upon gefitinib treatment. Importantly, inhibition of SREBP1 sensitizes EGFR-mutant therapy-resistant NSCLC to gefitinib both in vitro and in vivo models. These data suggest that sustained de novo lipogenesis through the maintenance of active SRBEP-1 is a key feature of acquired resistance to gefitinib in EGFR mutant lung cancer. Taken together, targeting SREBP1-induced lipogenesis is a promising approach to overcome acquired resistance to gefitinib in EGFR-mutant lung cancer.
Serving Students With Acquired Brain Injury: Understanding Long-Term Need and Outcomes After the BrainSTEPS Program
Authors: Riccardi Jessica Salley , Crook Libby , Eagan-Johnson Brenda , Vaccaro Monica , Ciccia Angela H. 
Published: November 2021

Purpose:
The purpose of this study was to inform school-based services for children with acquired brain injury (ABI) by describing and analyzing functional student-outcome data from a state-wide, school-based, school re-entry consultation program, BrainSTEPS (Strategies Teaching Educators, Parents, and Students), in Pennsylvania.

Method:
A nonexperimental, retrospective analysis was conducted with data collected during a pilot follow-up survey for BrainSTEPS. Caregivers reported on 337 students with ABI participating in BrainSTEPS.

Results:

Most students post-ABI who were participating in BrainSTEPS were enrolled in regular education and reported no ongoing symptoms, as well as no parent perception of need for additional BrainSTEPS consultation during the time period of the follow-up survey. Current receipt of therapy was significantly associated with injury type, χ
2
(1,
n
= 329) = 16.72,
p
< .001. A multiple logistic regression was significant (
p
< .001) in predicting the need for additional BrainSTEPS consultation. More severe injuries, educational placement postinjury of regular education with a 504 plan (compared to regular education), and current receipt of therapy significantly increased the odds of need for consultation.

Conclusions:
Due to the wide range of experiences of students in this sample, hospital-to-school transition services, educational supports and services, and long-term follow-up must be individualized for children with ABI. Speech-language pathologists are critical members of the school-based academic team for students with ABI to decrease long-term unmet needs.
Airgap and stray magnetic flux monitoring techniques for fault diagnosis of electrical machines: An overview
Authors: Mazaheri‐Tehrani Ehsan , Faiz Jawad 
Published: November 2021

AbstractFlux‐based fault diagnosis methods have attracted ever‐increasing attention from technical communities because of their potential diagnostic capabilities and ability to overcome weaknesses of the traditional methods such as motor current signature analysis (MCSA). This study reviews recent literature on these methods and addresses their strengths and limitations. Different types of flux sensors that can be used for fault diagnosis applications are also discussed. Flux‐based approaches are classified based on the type of utilised flux into internal (airgap flux) and external (stray flux) methods and compared with each other. The most common faults in both induction machines (IMs) and permanent magnet machines (PMMs), including inter‐turn short‐circuit (ITSC), airgap eccentricity (AGE), rotor broken bars (BRB), and irreversible demagnetisation (IDM) faults, are considered in this review. Finally, research gaps are identified, and some suggestions for future research in this area are provided.
Ultra‐wideband antenna system for in‐band full‐duplex applications
Authors: Hijazi Hadi , Le Roy Marc , Lababidi Raafat , Le Jeune Denis , Pérennec Andre 
Published: November 2021

AbstractIn this study, we present an ultra‐wideband full‐duplex system constituted of a wideband 4‐element Vivaldi array and wideband microstrip‐to‐slotline baluns. The proposed system is characterised by its simplicity, high directivity, and high self‐interference cancellation levels over a wide frequency bandwidth. The system is fabricated using basic printed‐circuit board (PCB) technology and can provide at least 50 dB of self‐interference cancellation over the bandwidth of operation, 4–40 GHz, with an average gain of 7.8 dBi. The system has a size of 8 cm × 8 cm × 9.4 cm and can be used as a high data rate link between two distant wireless nodes. To assess the merits of the proposed system and compare it to other published works, a new figure of merit (FoMWFD) dedicated to wide‐band full‐duplex antenna topologies is introduced in this study.