bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stakeholder consultation to facilitate implementation of interventions for prevention and promotion in mental health in Europe: introducing the design of the ICare Stakeholder Survey
Authors: Nitsch Martina , Waldherr Karin , Zeiler Michael , Klesges Lisa , Jacobi Corinna 
Published: March 2021

AbstractBackgroundOnline interventions to prevent mental health problems have proven to be effective. However, knowledge about their implementation in real-world practice as well as for dissemination to the target groups in different settings is scarce. The goal of the ‘ICare’ network is to establish a comprehensive model of eMental-health service delivery in and across different European countries. Since implementation and dissemination are influenced by many contextual factors, in the first phase of ICare a stakeholder survey was conducted. The survey aim was to explore stakeholders’ experiences, needs and attitudes regarding Internet-based prevention of mental health problems and hindering and fostering factors for implementation and dissemination. This article is part of a supplement and describes the design of the stakeholder survey. Survey results are published in separate articles in the same supplement.MethodsBased on a literature review and the individual characteristics of the ICare interventions, stakeholder groups were identified in different settings across six European countries. The RE-AIM framework guided the development of the research questions and survey instruments. A concurrent mixed methods design was applied comprising focus groups with the intended target groups of ICare interventions, an online questionnaire with potential facilitators/delivery staff and semi-structured interviews with policy makers.ConclusionThe challenge was to develop a design that allowed flexibility but at the same did not jeopardize the validity of the study. Implications drawn from this survey are not restricted to specific preventive interventions but will provide general information on how online mental illness prevention can be best implemented in various settings.
Support Exchanges Among Very Old Parents and Their Children: Findings From the Boston Aging Together Study
Authors: Boerner Kathrin , Kim Kyungmin , Kim Yijung K , Jopp Daniela S 
Published: March 2021

Abstract

Background and Objectives
Very old parents and their “old” children are a growing group in industrialized countries worldwide. Care needs of very old parents can be substantial, while children may also face their own age-related issues. Continued mutual support represents an important pathway to addressing emerging care needs. This study aimed to identify patterns of support exchanges occurring in very old parent–child dyads and to ascertain associated individual and relationship factors.

Research Design and Methods
Participants were 114 very old parents (aged ≥90) and their children (aged ≥65) from the Boston Aging Together Study. Data were collected using comprehensive, semistructured in-person interviews with both dyad members, including standardized assessments of support exchanges, relationship quality, health, and perceptions of family norms. Actor–Partner Interdependence Models were used to predict upward and downward support reported by children and parents.

Results
Both dyad members not only reported substantial upward support (child to parent) in all domains but also notable amounts of downward (parent to child) in the domains of emotional support, listening, and socializing. Findings showed significant associations of parent functional impairment, parent and child relationship quality, and child perceptions of family obligation with upward support and of relationship quality with downward support.

Discussion and Implications
Continued support exchanges among very old parents and their children indicated that intergenerational theories still hold up in very late-life relationships. Health care professionals should be aware that attention to relationship quality and family norms might be vital to ensure that support needs are met.
False lumen enhancement characteristics on computed tomography angiography predict risk of aneurysm formation in acute type B aortic dissection
Authors: Roseland Molly E , Ahmed Yunus , van Herwaarden Joost A , Moll Frans L , Yang Bo , Patel Himanshu J , Burris Nicholas S 
Published: March 2021

Abstract OBJECTIVESDifferential luminal enhancement [between true lumen (TL) and false lumen (FL)] results from differential flow patterns, most likely due to outflow restriction in the FL. We aimed to assess the impact of differential luminal enhancement at baseline computed tomography angiography on the risk of adverse events in patients with acute type B aortic dissection (TBAD).METHODSBaseline computed tomography angiographies of patients with acute TBAD between 2007 and 2016 (n = 48) were analysed using three-dimensional software at multiple sites along the descending thoraco-abdominal aorta. At each location, we measured contrast density in TL and FL [Houndsfield unit (HU)], maximal diameter (cm) and circumferential FL extent (°). Outcome data were collected via retrospective chart review. Multivariable logistic regression models were employed to determine the independent risk of TL–FL differential luminal enhancement on aneurysm formation (maximal diameter ≥55 mm) and medical treatment failure.RESULTSPatients were predominately male (75%) and 52.8±12.9 years at diagnosis. The mean follow-up was 5.9±2.6 years, and 42% (n = 20/48) patients were diagnosed with thoraco-abdominal aortic aneurysm. The baseline absolute difference between FL and TL contrast density measured at 2 cm distal to primary entry tear (TL–FLabs-Tear) was significantly higher among patients who developed aneurysm (26 HU, IQR: 15–53 vs 13 HU, IQR: 4–24, P = 0.001). Aneurysm development during follow-up was predicted by TL–FLabs-Tear (odds ratio 1.07, P = 0.012) and baseline maximal aortic diameter (odds ratio 1.90, P &lt; 0.001). High (≥18 HU) differential luminal enhancement was associated with lower rates of aneurysm-free survival and higher rates of medical treatment failure.CONCLUSIONSDifferential luminal enhancement may be a novel predictor of aneurysm formation among patients with acute TBAD.
Three-year study of pre-existing drug resistance substitutions and efficacy of bictegravir/emtricitabine/tenofovir alafenamide in HIV-1 treatment-naive participants
Authors: Acosta Rima K , Chen Grace Q , Chang Silvia , Martin Ross , Wang Xinxin , Huang Hailin , Brainard Diana , Collins Sean E , Martin Hal , White Kirsten L 
Published: March 2021

Abstract

Objectives
Two Phase 3, randomized, double-blind, active-controlled studies of initial HIV-1 treatment demonstrated that bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) was non-inferior to dolutegravir/abacavir/lamivudine (DTG/ABC/3TC; Study 1489) or to DTG+F/TAF (Study 1490) through 144 weeks. In both studies, there was no emergent resistance to study drugs. Here, the 3 year resistance analysis and impact of baseline resistance substitutions on treatment response are described.

Methods
Population sequencing of HIV-1 protease and reverse transcriptase (RT) was performed at screening. Retrospective baseline next generation sequencing of protease, RT and integrase (IN) was analysed at a ≥ 15% cutoff. Resistance analyses were performed on participants with confirmed viral rebound of HIV-1 RNA ≥200 copies/mL through Week 144 or last visit who did not resuppress to &lt;50 copies/mL while on study drug.

Results
Transmitted primary drug resistance substitutions were present in the following proportions of participants: integrase strand transfer inhibitor (INSTI) resistance (-R) in 1.3% (17/1270) of participants; NRTI-R in 2.7% (35/1274); NNRTI-R in 14.1% (179/1274); and PI-R in 3.5% (44/1274). These pre-existing resistance substitutions not associated with study drug did not affect treatment outcomes. One participant in the B/F/TAF group had pre-existing bictegravir and dolutegravir resistance substitutions (Q148H+G140S in integrase) at baseline and suppressed and maintained HIV-1 RNA &lt;50 copies/mL through Week 144. In total, 21 participants qualified for resistance testing [1.3% (8/634) B/F/TAF; 1.9% (6/315) DTG/ABC/3TC; 2.2% (7/325) DTG+F/TAF]; none had emergent resistance to study drugs.

Conclusions
Treatment with B/F/TAF, DTG/ABC/3TC, or DTG+F/TAF achieved high, durable rates of virological suppression in HIV-1 treatment-naive participants. The presence of pre-existing resistance substitutions did not affect treatment outcomes, and there was no treatment-emergent resistance.
Successful repair of spontaneous indirect bilateral carotid-cavernous fistula with coil embolization
Authors: Gasparian Suzie A , Chalam K V 
Published: March 2021

Abstract
Bilateral carotid-cavernous fistula (CCF) is a rare disease process, which portends poor visual outcome with delayed diagnosis and treatment. An 82-year-old woman presented with sudden onset of proptosis and decreased vision. A complete ophthalmologic examination along with magnetic resonance (MR) imaging of the brain and orbits, and MR angiography and venography of the brain confirmed the diagnosis of bilateral CCF. Diagnostic cerebral angiogram with concurrent coil embolization of the right cavernous sinus via left superior ophthalmic vein approach was performed. Bilateral indirect CCFs (type D CCF on the right and a type B CCF on the left) regressed completely after unilateral coil embolization. Visual acuity and limitation in extraocular movements significantly improved with complete resolution. In summary, we describe successful management of bilateral concurrent CCF with image-guided embolization and immediate recovery of vision and resolution of ophthalmological symptoms including proptosis and diplopia.
Induction of S-nitrosoglutathione reductase protects root growth from ammonium toxicity by regulating potassium homeostasis in Arabidopsis and rice
Authors: Zhang Lin , Song Haiyan , Li Baohai , Wang Meng , Di Dongwei , Lin Xianyong , Kronzucker Herbert J , Shi Weiming , Li Guangjie 
Published: March 2021

Abstract
Ammonium (NH4+) is toxic to root growth in most plants already at moderate levels of supply, but mechanisms of root growth tolerance to NH4+ remain poorly understood. Here, we report that high levels of NH4+ induce nitric oxide (NO) accumulation, while inhibiting potassium (K+) acquisition via SNO1 (sensitive to nitric oxide 1)/SOS4 (salt overly sensitive 4), leading to the arrest of primary root growth. High levels of NH4+ also stimulated the accumulation of GSNOR (S-nitrosoglutathione reductase) in roots. GSNOR overexpression improved root tolerance to NH4+. Loss of GSNOR further induced NO accumulation, increased SNO1/SOS4 activity, and reduced K+ levels in root tissue, enhancing root growth sensitivity to NH4+. Moreover, the GSNOR-like gene, OsGSNOR, is also required for NH4+ tolerance in rice. Immunoblotting showed that the NH4+-induced GSNOR protein accumulation was abolished in the VTC1- (vitamin C1) defective mutant vtc1-1, which is hypersensititive to NH4+ toxicity. GSNOR overexpression enhanced vtc1-1 root tolerance to NH4+. Our findings suggest that induction of GSNOR increases NH4+ tolerance in Arabidopsis roots by counteracting NO-mediated suppression of tissue K+, which depends on VTC1 function.
Digital humanities, knowledge complexity, and the five ‘aporias’ of digital research
Authors: Edmond Jennifer , Lehmann Jörg 
Published: March 2021

AbstractThis article introduces a frame of reference for understanding the fundamental challenges that inform digital humanities as an interdisciplinary research area between arts, humanities, information, and computer science. Its conclusions are based upon the evidence base developed within an EU-funded collaboration known as Knowledge Complexity, or KPLEX for short (www.kplex-project.eu), in particular via the project’s thirty-eight linked interviews about big data research. When viewed from the perspective of the digital humanities, five distinct points of ‘aporia’ with a significant impact on digital humanities (DH) appear in this corpus, places where the interviewees explicitly or tacitly expose gulfs between the epistemic cultures that contribute to DH and that create tensions between these disciplines, even as they seek to collaborate. This article will explore these areas of apparent irreconcilability, and conclude with a series of reflections on how digital humanities researchers might build upon their unique competency profile to negotiate within these critical conversations, in particular in the framework of the emerging subfield of critical digital humanities.
A data-driven approach to studying changing vocabularies in historical newspaper collections
Authors: Hengchen Simon , Ros Ruben , Marjanen Jani , Tolonen Mikko 
Published: March 2021

Abstract
Nation and nationhood are among the most frequently studied concepts in the field of intellectual history. At the same time, the word ‘nation’ and its historical usage are very vague. The aim in this article was to develop a data-driven method using dependency parsing and neural word embeddings to clarify some of the vagueness in the evolution of this concept. To this end, we propose the following two-step method. First, using linguistic processing, we create a large set of words pertaining to the topic of nation. Second, we train diachronic word embeddings and use them to quantify the strength of the semantic similarity between these words and thereby create meaningful clusters, which are then aligned diachronically. To illustrate the robustness of the study across languages, time spans, as well as large datasets, we apply it to the entirety of five historical newspaper archives in Dutch, Swedish, Finnish, and English. To our knowledge, thus far there have been no large-scale comparative studies of this kind that purport to grasp long-term developments in as many as four different languages in a data-driven way. A particular strength of the method we describe in this article is that, by design, it is not limited to the study of nationhood, but rather expands beyond it to other research questions and is reusable in different contexts.
Global RNA profiles show target selectivity and physiological effects of peptide-delivered antisense antibiotics
Authors: Popella Linda , Jung Jakob , Popova Kristina , Ðurica-Mitić Svetlana , Barquist Lars , Vogel Jörg 
Published: March 2021

AbstractAntisense peptide nucleic acids (PNAs) inhibiting mRNAs of essential genes provide a straight-forward way to repurpose our knowledge of bacterial regulatory RNAs for development of programmable species-specific antibiotics. While there is ample proof of PNA efficacy, their target selectivity and impact on bacterial physiology are poorly understood. Moreover, while antibacterial PNAs are typically designed to block mRNA translation, effects on target mRNA levels are not well-investigated. Here, we pioneer the use of global RNA-seq analysis to decipher PNA activity in a transcriptome-wide manner. We find that PNA-based antisense oligomer conjugates robustly decrease mRNA levels of the widely-used target gene, acpP, in Salmonella enterica, with limited off-target effects. Systematic analysis of several different PNA-carrier peptides attached not only shows different bactericidal efficiency, but also activation of stress pathways. In particular, KFF-, RXR- and Tat-PNA conjugates especially induce the PhoP/Q response, whereas the latter two additionally trigger several distinct pathways. We show that constitutive activation of the PhoP/Q response can lead to Tat-PNA resistance, illustrating the utility of RNA-seq for understanding PNA antibacterial activity. In sum, our study establishes an experimental framework for the design and assessment of PNA antimicrobials in the long-term quest to use these for precision editing of microbiota.
Habitual Path Dependence of Interorganizational Relationships—A Response to Sydow
Authors: Jensen Laura S , Sedgwick Donna 
Published: March 2021

Abstract
In “Path Dependence and the Roots of Interorganizational Relationship Challenges,” recently published by PPMG, we suggested the utility of path dependency theory in unpacking the developmental dynamics that may feed into contemporary problems of management and governance. Professor Jörg Sydow was moved to submit commentary on our article; we respond to his thoughtful comments in this essay.
Idiosyncratic Risk in Housing Markets
Authors: Giacoletti Marco 
Published: March 2021

AbstractThis paper studies the idiosyncratic risk component of individual house capital gains using data on resales and intermediate capital investments. The idiosyncratic component is large; its dynamics do not follow a random walk; and its magnitude is associated with proxies of information quality and market liquidity at the level of individual properties. Accounting for idiosyncratic risk substantially changes the assessment of the risk-return trade-off for housing: it reduces Sharpe ratios and makes them holding period dependent. I use a simple quantitative portfolio model to show that homeowners may be willing to make significant payments to insure against idiosyncratic housing risk.
TRIM33 gene somatic mutations identified by next generation sequencing in neoplasms of patients with anti-TIF1γ positive cancer-associated dermatomyositis
Authors: Cordel Nadège , Derambure Céline , Coutant Sophie , Mariette Xavier , Jullien Denis , Debarbieux Sébastien , Chosidow Olivier , Meyer Alain , Bessis Didier , Joly Pascal , Mathian Alexis , Levesque Hervé , Sabourin Jean-Christophe , Tournier Isabelle , Boyer Olivier ,   the OncoMyositis Study group, Amoura Zahir , Aouizerate Jessie , Benveniste Olivier , Brocheriou Isabelle , Dechelotte Benoit , Graveleau Julie , Guerzider Pascale , Isaac Sylvie , Kanitakis Jean , Lannes Béatrice , Lazure Thierry , Rigau Valérie , Sibilia Jean 
Published: March 2021

Abstract

Objective
To deep sequence the TRIM33 gene in tumours from patients with cancer-associated anti-TIF1γ autoantibody-positive dermatomyositis (DM) as TRIM33 somatic mutations in tumours may trigger this auto-immune disease.

Methods
Next generation sequencing of tumour DNA samples from patients with cancer-associated anti-TIF1γ autoantibody-positive DM. Fourteen tumours from 13 anti-TIF1γ autoantibody-positive DM individuals were sequenced along with two control tumours from non-DM individuals.

Results
Fourteen probable somatic variants from four tumours were identified in the TRIM33 gene.

Conclusion
These results are in accordance with the previous report of Pinal-Fernandez et al. and support the hypothesis of a role of TRIM33 gene mutations in the pathophysiology of anti-TIF1γ autoantibody-positive DM.
Comparative efficacy of low-dose versus regular-dose colchicine to prevent flares in gout patients initiated on urate-lowering therapies
Authors: Ahn Soo Min , Oh Ji Seon , Hong Seokchan , Lee Chang-Keun , Yoo Bin , Kim Yong-Gil 
Published: March 2021

Abstract

Objective
The objective of this study was to compare the prophylactic effect of regular-dose (RD, 1.2 mg/day) vs low-dose (LD, 0.6 mg/day) colchicine on gout flare when initiating urate-lowering therapy.

Methods
In this retrospective cohort study, we included gout patients who were initiated on either allopurinol or febuxostat, in combination with colchicine therapy and followed them up for 3 months. We analysed the rates of gout flare and adverse events according to the dose of colchicine. We performed the inverse probability of treatment weighting (IPTW) and weighted logistic regression analysis to assess the treatment effect. Analysis of gout flares and adverse events was performed on an intention-to-treat (ITT) and per-protocol (PP) basis.

Results
Of the total of 419 patients with gout, 177 patients (42.2%) received LD colchicine, whereas 242 patients (57.8%) received RD colchicine. Lower BMI and estimated glomerular filtration rate, and higher incidence of cardiovascular disease were seen in the LD group than in the RD group. In IPTW-adjusted analysis, events of gout flare were not significantly different between the LD and RD groups [ITT: 14.3% vs 11.3%; odds ratio (OR): 1.309, 95% CI: 0.668, 2.566, P = 0.432; PP: 15.3% vs 10.0%; OR: 1.623, 95% CI: 0.765, 3.443, P = 0.207]. However, LD colchicine was associated with a lower rate of adverse events than RD colchicine [ITT: 8.2% vs 17.9%; OR: 0.410, 95% CI: 0.217, 0.777; P &lt; 0.05; PP: 8.4% vs 17.2%; OR: 0.442, 95% CI: 0.223, 0.878; P &lt; 0.05].

Conclusion
Our data suggest that LD colchicine can adequately prevent gout flare with fewer adverse events compared with RD colchicine.
Substance Use and Utilization of Prenatal and Postpartum Care
Authors: Nidey Nichole , Kair Laura R. , Wilder Christine , Froehlich Tanya E. , Weber Stephanie , Folger Alonzo , Marcotte Michael , Tabb Karen , Bowers Katherine 
Published: March 2021

Objectives:
Prenatal and postpartum care for women with substance use is important due to increased risk of poor health outcomes. The influence of substance use on perinatal care utilization is not well characterized, especially postpartum care. The objective of this study was to examine the effect of substance use during pregnancy on prenatal and postpartum care utilization in a nationally representative sample and to identify maternal characteristics associated with inadequate prenatal and postpartum care among women with substance use.

Methods:
Pregnancy Risk Assessment Monitoring System data (2016–2018) from 8 states were used for this study. Logistic regression models adjusted for complex survey weights and confounder variables were used to estimate the odds of not receiving adequate prenatal care and postpartum care. Weighted Rao-Scott chi-square tests were used to examine maternal characteristics associated with care utilization among women who reported substance use during pregnancy.

Results:
The study included 15,131 women, with 5.3% who reported illicit substance use during pregnancy. In multivariable models, substance use was associated with an increase in the odds of not receiving adequate prenatal care (OR 1.69, CI 1.32, 2.17) and not receiving postpartum care (OR: 1.47, CI 1.10, 1.95). Among women who reported substance use, depression and smoking status were associated with not receiving adequate prenatal or postpartum care.

Conclusions:
Substance use during pregnancy is independently associated with disparities in prenatal and postpartum care access. Future studies are needed to identify how barriers lead to care inequalities and importantly, to identify strategies to improve care utilization.