bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chinese Adolescents’ Coping with COVID‐19: Relationships with Emotional Maladjustment and Parental Reactions to Negative Emotions
Authors: Shi Zeyi , Wang Qian 
Published: August 2021

Two hundred and thirteen Chinese adolescents (103 females; mean age = 12.18 years) completed a survey one year before (Wave 1) and five months after the COVID‐19 outbreak (Wave 2). Path analysis revealed that after controlling for adolescents’ emotional maladjustment at Wave 1, perceived parental supportive reactions to adolescents’ negative emotions at Wave 1 predicted adolescents’ greater use of approach coping and less use of avoidance coping at Wave 2, which in turn, was associated with less emotional maladjustment at Wave 2; conversely, perceived parental nonsupportive reactions at Wave 1 predicted adolescents’ greater use of avoidance coping at Wave 2, which in turn, was associated with greater emotional maladjustment at Wave 2. The findings were similar for mothers and fathers.
Peer Connectedness and Pre‐Existing Social Reward Processing Predicts U.S. Adolescent Girls’ Suicidal Ideation During COVID‐19
Authors: Hutchinson Emily A. , Sequeira Stefanie L. , Silk Jennifer S. , Jones Neil P. , Oppenheimer Caroline , Scott Lori , Ladouceur Cecile D. 
Published: August 2021

There is major concern about the impact of the COVID‐19 pandemic on adolescent suicidal ideation (SI) and peer relationships. We investigated (1) rates of SI and (2) the extent to which peer connectedness and pre‐existing neural activation to social reward predicted SI during the initial stay‐at‐home orders of the pandemic (April–May 2020) in a longitudinal sample of adolescent girls (N = 93; Mage = 15.06; 69% White non‐Hispanic). Daily diary and fMRI methods were used to assess peer connectedness and neural activation to social reward, respectively. Nearly 40% of girls endorsed SI during the initial stay‐at‐home orders. Greater peer connectedness and neural responsivity to anticipated social reward were associated with a reduced odds of SI during the pandemic among girls.
Longitudinal Changes in Adolescents’ School Bonding During the COVID‐19 Pandemic: Individual, Parenting, and Family Correlates
Authors: Maiya Sahitya , Dotterer Aryn M. , Whiteman Shawn D. 
Published: August 2021

The current study examined changes in adolescents’ school bonding from before to during the COVID‐19 pandemic and its individual, parenting, and family‐level correlates. Participants were two adolescents (50% male; Mage = 14 years) and one parent (85% female; Mage = 45 years) from 682 families (N = 2046) from an ongoing longitudinal study. Adolescents reported on their school bonding, stress, and coping, while parents reported on their involvement in adolescents’ education and pandemic‐related financial need. A two‐wave latent change score model suggested that adolescents’ school bonding decreased from before to during the COVID‐19 pandemic. Stress and pandemic‐related financial need served as risk factors, whereas coping and parental involvement served as protective factors against declines in adolescents’ school bonding.
Genomic signatures of inbreeding and mutation load in a threatened rattlesnake
Authors: Ochoa Alexander , Gibbs H. Lisle 
Published: August 2021

AbstractTheory predicts that threatened species living in small populations will experience high levels of inbreeding that will increase their genetic load, but recent work suggests that the impact of load may be minimized by purging resulting from long‐term population bottlenecks. Empirical studies that examine this idea using genome‐wide estimates of inbreeding and genetic load in threatened species are limited. Here we use individual genome resequencing data to compare levels of inbreeding, levels of genetic load (estimated as mutation load) and population history in threatened Eastern massasauga rattlesnakes (Sistrurus catenatus), which exist in small isolated populations, and closely related yet outbred Western massasauga rattlesnakes (Sistrurus tergeminus). In terms of inbreeding, S. catenatus genomes had a greater number of runs of homozygosity of varying sizes, indicating sustained inbreeding through repeated bottlenecks when compared to S. tergeminus. At the species level, outbred S. tergeminus had higher genome‐wide levels of mutation load in the form of greater numbers of derived deleterious mutations compared to S. catenatus, presumably due to long‐term purging of deleterious mutations in S. catenatus. In contrast, mutations that escaped species‐level drift effects within S. catenatus populations were in general more frequent and more often found in homozygous genotypes than in S. tergeminus, suggesting a reduced efficiency of purifying selection in smaller S. catenatus populations for most mutations. Our results support an emerging idea that the historical demography of a threatened species has a significant impact on the type of genetic load present, which impacts implementation of conservation actions such as genetic rescue.
Understanding the impact of academic difficulties among medical students: A scoping review
Authors: Kirtchuk David , Wells Geoffrey , Levett Tom , Castledine Clare , de Visser Richard 
Published: August 2021

AbstractBackgroundMany medical students may encounter a range of academic and personal challenges during their course of study, but very little is known about their experiences. Our aim was to review the literature to inform future scholarship and to inform policy change.MethodsA scoping review was conducted searching PubMed, MEDLINE, EMBASE, PsycInfo, British Education Index, Web of Science and ERIC for English language primary research with no date limits. This retrieved 822 papers of which eight met the requirements for inclusion in the review. Data were independently reviewed by two researchers and underwent thematic analysis by the research team.ResultsThree major themes emerged. Theme 1: ‘Identity preservation’ addressed students' aim to preserve their sense of self in the face of academic difficulty and their tendency to seek support. This connected the apprehension many students expressed about their educational institutions to Theme 2: ‘The dual role of the medical school’—medical schools are required to support struggling students but are predominantly seen as a punitive structure acting as the gatekeeper to a successful career in medicine. Students' apprehension and attempts to protect their identities within this complex landscape often resulted in ‘maladaptive coping strategies’ (Theme 3).ConclusionUnderstanding and exploring the academic challenges faced by medical students through their own experiences highlight the need for the development of more individualised remediation strategies. Educators may need to do more to bridge the gap between students and institutions. There is a need to build trust and to work with students to enhance their sense of self and remediate approaches to engagement with learning, rather than focusing efforts on success in assessments and progression.
Serrate‐Associated Protein 1, a splicing‐related protein, promotes miRNA biogenesis in Arabidopsis
Authors: Li Mu , Yu Huihui , Liu Kan , Yang Weilong , Zhou Bangjun , Gan Lu , Li Shengjun , Zhang Chi , Yu Bin 
Published: August 2021

Summary

MicroRNAs (miRNAs) are essential regulators of gene expression in metazoans and plants. In plants, most miRNAs are generated from primary miRNA transcripts (pri‐miRNAs), which are processed by the Dicer‐like 1 (DCL1) complex along with accessory proteins.

Serrate‐Associated Protein 1 (SEAP1), a conserved splicing‐related protein, has been studied in human and yeast. However, the functions of SEAP1 in plants remain elusive.

Lack of SEAP1 results in embryo lethality and knockdown of SEAP1 by an artificial miRNA (amiRSEAP1) causes pleiotropic developmental defects and reduction in miRNA accumulation. SEAP1 associates with the DCL1 complex, and may promote the interaction of the DCL1 complexes with pri‐miRNAs. SEAP1 also enhances pri‐miRNA accumulation, but does not affect pri‐miRNA transcription, suggesting it may indirectly or directly stabilize pri‐miRNAs. In addition, SEAP1 affects the splicing of some pri‐miRNAs and intron retention of messenger RNAs at global levels.

Our findings uncover both conserved and novel functions of SEAP1 in plants. Besides the role as a splicing factor, SEPA1 may promote miRNA biogenesis by positively modulating pri‐miRNA splicing, processing and/or stability.
Heterodimer formed by ROC8 and ROC5 modulates leaf rolling in rice
Authors: Xu Yang , Kong Weiyi , Wang Fangquan , Wang Jun , Tao Yajun , Li Wenqi , Chen Zhihui , Fan Fangjun , Jiang Yanjie , Zhu Qian‐Hao , Yang Jie 
Published: August 2021

SummaryModerately rolled leaf is one of the target traits of the ideal plant architecture in rice breeding. Many genes, including homeodomain leucine zipper IV transcription factors ROC5 and ROC8, regulating rice leaf rolling have been cloned and functionally analysed. However, the molecular mechanism by which these genes modulate leaf‐rolling remains largely elusive. In this study, we demonstrated the transcription activation activity of both ROC8 and ROC5. Overexpressing ROC8 caused adaxially rolled leaves due to decreased number and size of bulliform cells, whereas knockout of ROC8 induced abaxially rolled leaves due to increased number and size of bulliform cells. ROC8 and ROC5 each could form homodimer, but ROC8 interacted preferably with ROC5 to forms a heterodimer. Importantly, we showed that the ROC8‐ROC5 heterodimer rather than the homodimer of ROC8 or ROC5 was functional as neither overexpressing ROC8 in the ROC5 mutant nor overexpressing ROC5 in the ROC8‐knockout line could rescue the mutant phenotype. This was further partially supported by the identification of a large number of common differentially expressed genes in single and double mutants of roc8 and roc5. ROC8 and ROC5 were functionally additive as the phenotype of abaxially rolled leaves was stronger in the roc5roc8 double mutant than in their single mutants. Our results provide evidence for the role of dimerization of ROC members in regulating leaf rolling of rice.
Virtual group visits to reduce psychosocial distress and racial disparities in pediatric vitiligo and alopecia areata patients
Authors: Khosla Natalia N. , Grullon Karina , Rosenblatt Adena E. 
Published: August 2021

AbstractWe examined the potential for virtual, pediatric group visits to reduce racial disparities in psychosocial isolation and access to care among children of color with pediatric vitiligo and alopecia areata as well as their caregivers. We have conducted 10 visits with 30 pediatric skin of color patients between 5 and 16 years old: 18 patients with alopecia areata, 12 with vitiligo, 59% female, 64% Black, and 23% Latinx, and 33 parents. After the visits, children and parents felt they had more people they knew and could reach out to about their dermatologic condition, the visits exceeded both children’s and parents’ expectations, and both children and parents reported that they would continue attending future group visits if offered. Group visits in the virtual format may present an opportunity for reducing racial disparities in psychosocial isolation and access to care across geographic locations in pediatric dermatology.
Domino transplantation for pediatric liver recipients: Obstacles, challenges, and successes
Authors: Raghu Vikram K. , Carr‐Boyd Peter D. , Squires James E. , Vockley Jerry , Goldaracena Nicolas , Mazariegos George V. 
Published: August 2021

AbstractBackgroundDomino liver transplantation aims to address the need to increase the liver donor supply. In a domino liver transplant, the domino recipient receives the explanted liver from the recipient of a traditional liver transplant. The domino donor typically requires liver transplant to correct a metabolic disorder; the explanted liver thus has a single gene defect but otherwise normal structure and function.MethodsIn this review, we detail the history of domino liver transplantation, appropriate domino donor indications, the technical advances to the surgical approach, current outcomes, and future opportunities.ResultsDevelopment of de novo disease in the domino recipient has relegated adult domino liver transplant to be considered a source of marginal donor livers. However, pediatric domino liver transplant has leveraged certain metabolic disorders, especially maple syrup urine disease, in which the liver enzyme deficiency can be compensated by the systemic presence of sufficient enzyme. Advances in the surgical aspects of assuring adequate length of vasculature have improved the safety of the procedure in both domino donors and recipients.ConclusionsPediatric domino liver transplant utilizing domino donors with specific metabolic liver diseases should be considered a viable live donor option for children awaiting liver transplant.
Discovery of a hidden Triassic Arc in the Southern South China Sea: Evidence for the breakaway of a ribbon continent with implications for the evolution of the Western Pacific margin
Authors: Wei Wu , Liu Chuan‐Zhou , Hou Yi‐Fei , Deng Cheng‐Long , Yan Wen , Li Xian‐Hua , Chung Sun‐Lin , Mitchell Ross N. 
Published: August 2021

AbstractPaleo‐Pacific subduction generated a prolonged active continental margin along the coast of the South China Block (SCB). A Triassic magmatic gap was argued to have occurred and was ascribed to flat‐slab subduction of an oceanic plateau. We study for the first time a >330‐m‐long core of typical arc volcanics dated at ca. 218 Ma from the Meiji Atoll in the southern South China Sea (SCS). Paleomagnetism suggests 4.1°± 1.5° of post‐eruption southward drift. These observations clearly support the existence of a Triassic arc in the SCB and imply that part of the arc later split off and drifted southward during the opening of the SCS in the Oligocene. Our results better constrain the lateral extent of the proposed flat‐slab subduction along the margin of the SCB. Moreover, we provide direct evidence of how the breakaway of ribbon continents operated in active continental margins, a recurrent scenario that has been invoked for Phanerozoic tectonics and continental growth throughout Asia.
Exploring eating behavior and psychological mechanisms associated with obesity in patients with craniopharyngioma: a scoping review protocol
Authors: Hinton Elanor C. , Elsworth Rebecca L. , Naeem Nimra , Szymkowiak Sophie B. , Perry Rachel , Candler Toby P. , Crowne Elizabeth C. , Gatta-Cherifi Blandine 
Published: August 2021

ABSTRACT

Objective:
The objective of the review is to explore the evidence on the behavioral and psychological mechanisms underlying the development of obesity in patients with craniopharyngioma. The review will map the available evidence, identify gaps in the literature, and find avenues of future intervention.

Introduction:
Craniopharyngiomas are low-grade intracranial tumors of the supersellar region. Obesity is associated with the tumor or surgery or radiotherapy to treat the tumor; however, the behavioral and psychological processes contributing to that association are not clear. This review will provide a synthesized evidence base of the relevant research.

Inclusion criteria:
This review will consider published studies with all types of study designs, including patients with childhood- or adult-onset craniopharyngioma. Articles assessing factors that may impact eating behavior will be included based on the following categories: eating behavior, obesity, neuroimaging, endocrine response, energy expenditure, sleep, and neuropsychology.

Methods:
MEDLINE, Embase, and PsycINFO will be searched, in addition to the Cochrane Library, Web of Science, Scopus, ClinicalTrials.gov, NICE evidence search, and International Standard Randomised Controlled Trial Number (ISRCTN). No limits will be placed on the scope of the search. The methodology will follow a three-stage process with two independent reviewers at each stage, including an initial database search, screening of titles and abstracts of retrieved studies, full-text assessment for inclusion criteria, and hand-searching of reference lists. Data will be extracted using a standardized charting form and summarized in tables. The data will be synthesized using a narrative summary and diagrammatic map and will be based on the evidence for each of the proposed research categories.
Rating scales for medication adherence in people living with Parkinson's disease: a systematic review protocol
Authors: Tosin Michelle Hyczy S. , de Oliveira Beatriz Guitton R.B. , Goetz Christopher G. , Morisky Donald , McConvey Victor , Stebbins Glenn T. 
Published: August 2021

ABSTRACT

Objective:
The objective of the review is to evaluate the measurement properties of rating scales that have been used to assess the components of medication adherence in patients with Parkinson's disease.

Introduction:
Drug therapy is a central strategy in the control of Parkinson's disease symptoms. Measuring behaviors related to medication adherence in patients with Parkinson's disease is vital to understanding the therapeutic response. Consequently, it is necessary to define which instrument offers the most reliable and valid screening.

Inclusion criteria:
This review will consider studies in English and Portuguese using structured rating scales to assess medication adherence in people with Parkinson's disease. Studies including data from patients with different diseases in addition to Parkinson's disease will be included only if data are clearly available for each disorder covered. Study protocols, letters to the editors, reviews, and studies with clinical judgment scales but no operationally defined anchor points will be excluded.

Methods:
A three-step search strategy will be utilized. Databases will include MEDLINE (PubMed), LILACS (BVS Portal), PsycINFO (APA PsycNet), CINAHL (EBSCO), Web of Science (Clarivate Analytics), Embase, and Scopus (Elsevier). The search strategy will be presented using a PRISMA flow diagram. Eligible studies will be critically appraised for methodological quality using the COSMIN Risk of Bias checklist. Criteria for good measurement properties of the selected scales will be summarized narratively using COSMIN, the Movement Disorder Society Rating Scale Program Committee methodology, the World Health Organization concepts, and the ABC taxonomy of medication adherence. The certainty of the evidence will be determined using the modified GRADE recommendations.

Systematic review registration number:
PROSPERO (CRD42021211099)
Rotordynamic Characteristics of the Straight-Through Labyrinth Seal Based on the Applicability Analysis of Leakage Models Using Bulk-Flow Method
Authors: Wang Tianhao , Li Zhigang , Li Jun 
Published: August 2021

Abstract
Labyrinth seals are widely applied in the turbomachinery to control the leakage flow through the clearance between stationary and rotating components. The fluid excitation induced by the labyrinth seal would deteriorate the stability of turbomachinery shaft. Developing an accurate and rapid prediction approach is crucial to the analysis of the fluid excitation rotordynamics of labyrinth seals. The objective of this study is to analyze the applicability of leakage models using Bulk-Flow method and investigate the factors affecting the rotordynamic characteristics of the labyrinth seal. An elliptical orbit for rotor whirling was assumed in the one-control-volume Bulk-Flow model considering an isentropic process to predict the frequency-dependent rotordynamic coefficients of the labyrinth seal. The optimal leakage model was determined by comprehensively analyzing the applicability of seventy-two leakage models. Employing the optimal leakage model in the Bulk-Flow method, the effects of sealing clearance, pressure ratio, preswirl ratio and rotational speed on the rotordynamic characteristics of the labyrinth seal were investigated. The conclusions show that the Bulk-Flow method has an average prediction error of around 10% for the leakage flow rate, cross-coupled stiffness and direct damping when equipped with the optimal leakage model. Increasing preswirl ratio has a significantly destabilizing effect on the rotor stability, while the influence of increasing rotational speed is strongly related to preswirl direction. The effective damping of the labyrinth seal is sensitive to the inlet pressure, but insensitive to the outlet pressure and sealing clearance. The crossover frequency is almost impervious to the inlet pressure, outlet pressure and sealing clearance.
Contrast sensitivity and quality of life following intravitreal ranibizumab injection for central retinal vein occlusion
Authors: Murakami Tomoya , Okamoto Fumiki , Sugiura Yoshimi , Morikawa Shohei , Okamoto Yoshifumi , Hiraoka Takahiro , Oshika Tetsuro 
Published: August 2021

Synopsis/precisWe investigated the relationship between contrast sensitivity (CS) and vision-related quality of life (VR-QOL) in patients with central retinal vein occlusion following ranibizumab intravitreal injection; CS showed a stronger association with VR-QOL than visual acuity.Background/aimsTo investigate the relationship between CS, VR-QOL and optical coherence tomography (OCT) findings in patients with cystoid macular oedema secondary to central retinal vein occlusion (CRVO-CMO) following intravitreal injection of ranibizumab.MethodsThis was a multicentre, open-label, single-arm, prospective study. The study included 23 patients with CRVO-CMO who were followed up for 12 months after treatment. The best-corrected visual acuity (BCVA), letter contrast sensitivity (LCS) and OCT images were obtained every month. For VR-QOL assessment, the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) was administered to the patients before treatment and at 3, 6 and 12 months following treatment.ResultsThe LCS and VFQ-25 composite score improved significantly from baseline to 12 months following treatment. The multiple regression analysis revealed that the LCS of the affected eye and BCVA of the fellow eye were related to the VFQ-25 composite score following treatment. The LCS improvement showed a significant correlation with the improvement in the VFQ-25 composite score, whereas the BCVA improvement was not correlated with the improvement in the VFQ-25 composite score. Stepwise multiple regression analyses revealed that, at the time of macular oedema resolution, the distance between the external limiting membrane and retinal pigment epithelium (ELM-RPE) and average ganglion cell-inner plexiform layer (GCIPL) thickness were associated with LCS.ConclusionCS had a stronger association with VR-QOL than with BCVA in patients with CRVO-CMO. With the resolution of macular oedema, CS was associated with ELM-RPE thickness and average GCIPL thickness.