bluuebunny/crossref_metadata_2025_split huggingface dataset:
Will GHz burst mode create a new path to femtosecond laser processing?
Authors: Sugioka Koji 
Published: September 2021

Abstract
The GHz burst mode of femtosecond laser pulses can significantly improve ablation efficiency without deteriorating ablation quality. However, various parameters involved in GHz burst mode make it difficult to optimize the processing for practical implementation. In this Perspective, the author gives the history, current status, and future challenges and prospects of this new strategy to answer the question, ‘will GHz burst mode create a new path to femtosecond laser processing?’
A Systematic Review and Meta-analysis of the Outcome Expectancy Construct in Physical Activity Research
Authors: Bohlen Lauren Connell , Emerson Jessica A , Rhodes Ryan E , Williams David M 
Published: September 2021

Abstract

Background
Cognition-based theories dominate physical activity (PA) research, and many include a construct broadly defined as “beliefs about the consequences of behavior” (e.g., outcome expectancies, perceived benefits) hereafter referred to as perceived consequences.

Purpose
With the quantity of available research on this topic, it is important to examine whether the literature supports perceived consequences as a predictor of PA.

Methods
A meta-analysis examining longitudinal associations between perceived consequences and PA in adults was conducted. Studies were eligible if (a) perceived consequences were measured at a time point prior to PA, and (b) the target behavior was a form of PA. An omnibus meta-analysis estimating the mean effect of all included studies, and separate meta-analyses for perceived consequences content categories were conducted.

Results
This search yielded 6,979 articles, of these, 110 studies met inclusion criteria. Studies were published between 1989 and 2020, with sample sizes ranging from 16 to 2,824. All studies were evaluated as moderate to high quality. A small positive bivariate association was identified (r = 0.11; 95% CI [0.09, 0.13]) between perceived consequences and PA. Significant associations were identified for time, health, self-evaluative, psychological, and affective consequences. There was no association between perceived weight-related consequences and PA.

Conclusions
The findings emphasize the variability with which existing studies have examined perceived consequences in the PA literature. Future research might examine whether these are important distinctions for understanding PA. Overall, the results suggest utility in examining perceived consequences as a predictor of PA, but constructs with more robust associations may require priority.
Odor-evoked Autobiographical Memory in Alzheimer’s disease?
Authors: El Haj Mohamad 
Published: September 2021

Abstract

Objective
Because memory decline is the hallmark of Alzheimer’s disease (AD), an important endeavor for both clinicians and researchers is to improve memory performances in AD. This can be pursued by olfactory stimulation of memory in patients with AD and by studying the effects of olfactory stimulation on autobiographical memory (i.e., memory for personal information). The effects of olfactory stimulation on autobiographical memory in patients with mild AD have been reported by recent research. We thus provide the first comprehensive overview of research on odor-evoked autobiographical memory in AD. We also establish the basis for solid theoretical analysis concerning the memory improvement reported by research on odor-evoked autobiographical memory in AD.

Method
We examined literature on odor-evoked autobiographical memories in AD and propose the “OdAMA” (Odor-evoked Autobiographical Memory in Alzheimer’s disease) model.

Results and discussion
According to OdAMA model, odor exposure activates involuntary access to specific autobiographical memories, which promotes enhanced experience subjective of retrieval in patients with AD and improves their ability to construct not only recent and remote events but also future ones. The OdAMA model could serve as a guide for researchers and clinicians interested in odor-evoked autobiographical memory in AD.
Hashing out current social media use in eosinophilic esophagitis
Authors: Thanawala Shivani U , Beveridge Claire A , Muir Amanda B , Strobel Mary Jo , Westcott-Chavez Amity , Serper Marina , Yang Yu-Xiao , Lynch Kristle L 
Published: September 2021

Summary

Background
Patients affected by chronic illnesses have increasingly turned to social media to gather disease-related information and connect with other patients. Eosinophilic esophagitis (EoE) is a chronic disease with rapidly evolving management options. The aims of this study are to describe the current use of social media in EoE patients and caregivers, evaluate whether use of social media to learn about EoE is associated with higher medical knowledge of this disease, and evaluate social media factors that could result in improved patient and caregiver disease understanding.

Methods
We surveyed individuals 18 years or older in July 2020 who identified as either having EoE, or as being a caregiver for someone with EoE, through an invitation link sent to email subscribers of the American Partnership for Eosinophilic Disorders.

Results
Of the 212 survey responders, 82.5% used social media to learn about EoE. Caregivers were more likely to use social media than patients (OR 2.30, 95% CI 1.11–4.76). Social media use was not associated with higher knowledge of EoE. Distrust of posted content was the largest barrier to use and 87.7% of responders believed that physician contribution to posts would enhance the quality of information.

Conclusions
In one of the first known studies to evaluate use of social media in the context of EoE, we found that a majority of patient and caregiver respondents use social media to learn about EoE. This highlights the potential opportunity to leverage social media to provide current and accurate EoE educational content for patients and caregivers.
Density-Dependent Cannibalism in Dragonfly Nymphs (Odonata: Anisoptera) Overwintering in Temperate Freshwater Ponds
Authors: Clark Candace , Hossie Thomas J , Beresford David V 
Published: September 2021

Abstract
Density-dependent mortality by predation and cannibalism has been observed in aquatic insects such as dragonflies in response to shrinking habitat caused by summer drought. Winter conditions might also reduce the amount of livable habitat in temperate ponds and could augment rates of cannibalism. We hypothesized that cannibalism in dragonfly nymphs would increase in winter due to a seasonal decrease in available habitat caused by stratified lower oxygen levels leading to increased nymph density around pond edges. To determine whether cannibalism in nymphs is density-dependent and size-dependent (i.e., with smaller nymphs consumed) we experimentally manipulated nymph density in aquaria. To evaluate whether these patterns are observed in nature during the winter, we conducted field surveys for nymphs in two ponds across the fall and winter seasons. When nymphs were housed at different densities for 24 h, cannibalism was density-dependent, and only smaller nymphs were preyed upon. Our field surveys found that fewer nymphs were caught in the late winter sampling period (mixed-effects model, P &lt; 0.001), and that these were larger than nymphs caught in the fall, although both patterns were restricted to the deeper pond (P &lt; 0.05). Our results were consistent with the process we hypothesized, and the observed reduction in dissolved oxygen at the bottom of the deeper pond. The lack of significant changes to the relative abundance and size of nymphs in the shallower pond reveals that differences in pond characteristics can influence the degree to which winter conditions induce density-dependent cannibalism among dragonfly nymphs.
Case report: incessant ventricular fibrillation in a conscious left ventricular assist device patient
Authors: Jakstaite Aiste Monika , Luedike Peter , Wakili Reza , Kochhäuser Simon , Ruhparwar Arjang , Rassaf Tienush , Papathanasiou Maria 
Published: September 2021

Abstract

Background
Ventricular arrhythmia in left ventricular assist device (LVAD) recipients represents a challenging clinical scenario and the optimal treatment strategy in this unique patient population still needs to be defined.

Case summary
We report on a 61-year-old LVAD patient with incessant ventricular fibrillation (VF) despite multiple unsuccessful attempts to restore normal rhythm with external defibrillation and antiarrhythmic medication. He remained initially stable as an outpatient and subsequently developed secondary organ failure.

Discussion
This case demonstrates that under LVAD support long-term haemodynamic stability is possible even in case of VF, a situation that resembles Fontan circulation. However, ventricular arrhythmias are associated with a high risk of secondary organ damage due to right heart failure if left untreated. In case of refractory ventricular tachycardia or electrical storm listing for heart transplantation with high priority status should be pursued when possible. Alternatively, catheter ablation may be considered in selected cases and be performed in experienced centres in close collaboration with all involved specialists.
Erdheim–Chester disease presenting as an intracardiac mass and pericardial effusion confirmed by biopsy: a case report
Authors: Yoon Minjae , Lee Seung Hyun , Shim Hyo Sup , Kang Seok-Min 
Published: September 2021

Abstract

Background
Erdheim–Chester disease (ECD) is a rare non-Langerhans cell histiocytosis that can affect the bones, heart, lungs, brain, and other organs. Cardiovascular involvement is common in ECD and is associated with a poor prognosis. Here, we report a case of ECD presenting as an intracardiac mass and pericardial effusion confirmed by biopsy with sternotomy.

Case summary
A 54-year-old man was admitted because of dyspnoea. He was previously diagnosed with bilateral hydronephrosis and retroperitoneal fibrosis. Echocardiography revealed a large amount of pericardial effusion and echogenic mass on the right atrial (RA) side and atrioventricular (AV) groove. Cardiac magnetic resonance imaging and positron emission tomography-computed tomography (CT) revealed infiltrative mass-like lesions in the RA and AV groove. Pericardial window formation and pericardial biopsy were performed, and the pathologic results showed only pericardial fibrosis with no specific findings. Bone scan revealed increased uptake in the long bones. Considering the high probability of ECD based on the patient’s manifestations and the imaging findings, we performed a cardiac biopsy with median sternotomy despite initial insufficient pathologic results in the pericardial biopsy. The surgical findings included multiple irregular and firm masses on the cardiac wall and large vessels; after obtaining a large amount of suspicious mass, ECD accompanied with CD68 (+) and BRAF V600E mutation was confirmed.

Discussion
Erdheim–Chester disease can be associated with various forms of cardiovascular involvement. Considering the multi-systemic manifestations and difficulty in identifying this rare disease, a comprehensive and meticulous diagnostic work-up is crucial.
A haemodynamic conundrum: a case report of a patient with concurrent pulmonary arterial hypertension and hypertrophic obstructive cardiomyopathy
Authors: Hassanin Ahmed , Rzechorzek Wojciech , Naidu Srihari S , Lanier Gregg M 
Published: September 2021

Abstract

Background
The co-existence of hypertrophic obstructive cardiomyopathy (HOCM) and pulmonary arterial hypertension (PAH) is extremely rare and poses a management conundrum. This is the first case report in the published literature to describe the diagnosis and management of a patient with both conditions.

Case summary
A 49-year-old female with a history of HOCM and recently diagnosed scleroderma presented to the clinic with progressive dyspnoea. Transthoracic echocardiogram demonstrated left ventricular outflow tract (LVOT) obstruction at rest, and elevated pulmonary artery (PA) pressure. Cardiac catheterization (CC) demonstrated an LVOT gradient of 150 mmHg, PA pressure of 88/32 mmHg, pulmonary capillary wedge pressure (PCWP) 12 mmHg, pulmonary vascular resistance 14.8 Wu, and a cardiac index of 1.6 L/min/m2. The differential diagnosis for the dyspnoea included combined pre- and post-capillary pulmonary hypertension from longstanding HOCM vs. scleroderma associated PAH. Tadalafil was added to the patient’s medical regimen of metoprolol but it was stopped because the patient developed pulmonary oedema. Alcohol septal ablation was undertaken with improvement in the LVOT gradient, but only a modest improvement in her dyspnoea. Repeat CC demonstrated worsening PAH. Vasodilatory testing with nitric oxide led to an improvement in the PA pressure with minimal increase of the PCWP. Hence, she was started on treprostinil and macitentan, with significant improvement in her dyspnoea on follow-up.

Conclusion
In patients with concurrent HOCM and advanced PAH, a multidisciplinary treatment approach is needed to rapidly and safely optimize the background of HOCM in order to permit the use of PAH-specific medications.
Worldwide differences in primary prevention implantable cardioverter defibrillator utilization and outcomes in hypertrophic cardiomyopathy
Authors: Nauffal Victor , Marstrand Peter , Han Larry , Parikh Victoria N , Helms Adam S , Ingles Jodie , Jacoby Daniel , Lakdawala Neal K , Kapur Sunil , Michels Michelle , Owens Anjali T , Ashley Euan A , Pereira Alexandre C , Rossano Joseph W , Saberi Sara , Semsarian Christopher , Ware James S , Wittekind Samuel G , Day Sharlene , Olivotto Iacopo , Ho Carolyn Y 
Published: September 2021

Abstract

Aims
Risk stratification algorithms for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) and regional differences in clinical practice have evolved over time. We sought to compare primary prevention implantable cardioverter defibrillator (ICD) implantation rates and associated clinical outcomes in US vs. non-US tertiary HCM centres within the international Sarcomeric Human Cardiomyopathy Registry.

Methods and results
We included patients with HCM enrolled from eight US sites (n = 2650) and five non-US (n = 2660) sites and used multivariable Cox-proportional hazards models to compare outcomes between sites. Primary prevention ICD implantation rates in US sites were two-fold higher than non-US sites (hazard ratio (HR) 2.27 [1.89–2.74]), including in individuals deemed at high 5-year SCD risk (≥6%) based on the HCM risk-SCD score (HR 3.27 [1.76–6.05]). US ICD recipients also had fewer traditional SCD risk factors. Among ICD recipients, rates of appropriate ICD therapy were significantly lower in US vs. non-US sites (HR 0.52 [0.28–0.97]). No significant difference was identified in the incidence of SCD/resuscitated cardiac arrest among non-recipients of ICDs in US vs. non-US sites (HR 1.21 [0.74–1.97]).

Conclusion
Primary prevention ICDs are implanted more frequently in patients with HCM in US vs. non-US sites across the spectrum of SCD risk. There was a lower rate of appropriate ICD therapy in US sites, consistent with a lower-risk population, and no significant difference in SCD in US vs. non-US patients who did not receive an ICD. Further studies are needed to understand what drives malignant arrhythmias, optimize ICD allocation, and examine the impact of different ICD utilization strategies on long-term outcomes in HCM.
Trends in Cardiovascular Disease by Asian American, Native Hawaiian, and Pacific Islander Ethnicity, Medicare Health Outcomes Survey 2011–2015
Authors: Đoàn Lan N , Takata Yumie , Hooker Karen , Mendez-Luck Carolyn , Irvin Veronica L 
Published: September 2021

AbstractBackgroundThe burden of cardiovascular disease (CVD) is increasing in the aging population. However, little is known about CVD risk factors and outcomes for Asian American, Native Hawaiian, and Other Pacific Islander (NH/PI) older adults by disaggregated subgroups.MethodsData were from the Centers for Medicare and Medicaid Services 2011–2015 Health Outcomes Survey, which started collecting expanded racial/ethnic data in 2011. Guided by Andersen and Newman’s theoretical framework, multivariable logistic regression analyses were conducted to examine the prevalence and determinants of CVD risk factors (obesity, diabetes, smoking status, hypertension) and CVD conditions (coronary artery disease [CAD], congestive heart failure [CHF], myocardial infarction [MI], other heart conditions, stroke) for 10 Asian American and NH/PI subgroups and White adults.ResultsAmong the 639 862 respondents, including 26 853 Asian American and 4 926 NH/PI adults, 13% reported CAD, 7% reported CHF, 10% reported MI, 22% reported other heart conditions, and 7% reported stroke. CVD risk factors varied by Asian American and NH/PI subgroup. The prevalence of overweight, obesity, diabetes, and hypertension was higher among most Asian American and NH/PI subgroups than White adults. After adjustment, Native Hawaiians had significantly greater odds of reporting stroke than White adults.ConclusionsMore attention should focus on NH/PIs as a priority population based on the disproportionate burden of CVD risk factors compared with their White and Asian American counterparts. Future research should disaggregate racial/ethnic data to provide accurate depictions of CVD and investigate the development of CVD risk factors in Asian Americans and NH/PIs over the life course.
Nutrition integrated agricultural extension—a case study in Western Kenya
Authors: Keding Gudrun B , Gramzow Andreas , Ochieng Justus , Laizer Alaik , Muchoki Charity , Onyango Charles , Hanson Peter , Yang Ray-Yu 
Published: September 2021

Summary
Integrating nutrition communication in agricultural intervention programs aimed at increased food availability and accessibility in resource-poor areas is crucial. To enhance the sustainability and scalability of nutrition communication, the present study piloted the approach of ‘nutrition integrated agricultural extension’ and tested nutrition-related outcomes with two types of nutrition messages (specific vs. sensitive) and two delivery channels (public sector vs. private sector). The study intervention comprised (i) vegetable seed kit distribution, (ii) ongoing agricultural extension activities by public or private sectors and (iii) nutrition communication with two different messages. The intervention was tested with three treatment arms and reached 454 farmers (&gt;65% female) in rural Kakamega County, Western Kenya. Pre-/post-surveys measured outcome variables focused on farmers’ nutrition-related knowledge, attitudes and practices in vegetable production and consumption, and household dietary diversity score. Results showed that all treatments increased nutrition knowledge (p &lt; 0.05). Nutrition-specific communication was more effective than nutrition-sensitive communication. Nutrition communication through either the public or the private agricultural sector was both effective. Before the study intervention, many participants believed that vegetable consumption was beneficial and wanted to increase intake. After the intervention, the number of participants who felt eating more vegetables was challenging decreased slightly. Nutrition communication was found to be especially important in conveying recommended food amounts and promoting increased vegetable consumption. Seasonality affected on-farm crop diversity and vegetable consumption results in this study.
Enablers and barriers English secondary schools face in promoting healthy diet and physical activity behaviours
Authors: McHugh Camilla , Lloyd Jenny , Logan Stuart , Wyatt Katrina 
Published: September 2021

Summary
This study sought to understand the current challenges mainstream secondary schools in England face in creating a health promoting school culture for diet and physical activity behaviours. An in-depth qualitative case study of two purposely selected state-funded schools, including interviews with teachers, observations of school activities including meal breaks and a qualitative survey with parents was done. Inductive thematic analysis was used to explore emerging themes. Additional interviews with the leadership team from four further schools were used to develop and refine emerging themes. Four main themes emerged from the data: competing pressures, school environment, personnel and policy. Results demonstrate that schools recognize they have role to play in promoting healthy lifestyle behaviours to pupils; however, several significant barriers were identified such as lack of government support and regulation, school structures and organization, focus on core subjects, business-run canteens and lack of family and community engagement. Given the importance of maintaining a healthy weight throughout the life course, schools have an important role to play in creating healthy environments in which students can easily make a healthy choice. Future school promotion initiatives need to consider addressing the barriers that schools face by working with them and the communities in which they are embedded.
Characteristics of Persons With Secondary Detection of Severe Acute Respiratory Syndrome Coronavirus 2 ≥90 days After First Detection, New Mexico 2020
Authors: Hicks Joseph T , Das Smita , Matanock Almea , Griego-Fisher Anastacia , Sosin Daniel 
Published: September 2021

Abstract
The New Mexico Department of Health (NMDOH) conducted a matched case-control study to compare 315 persons (cases) with and 945 persons (controls) without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) secondary detection (ie, positive SARS-CoV-2 test ≥90 days after first detection as of December 10, 2020). Compared with controls, cases had greater odds of higher SARS-CoV-2 testing frequency (adjusted odds ratio [aOR] = 1.2), being female (aOR = 1.6), being non-Hispanic American Indian/Alaska Native (aOR = 2.3), having diabetes mellitus (aOR = 1.8), and residing and/or working in detention and/or correctional facilities (aOR = 4.7). Diagnostic tools evaluating infectiousness at secondary detection are urgently needed to inform infection control practices.
The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development
Authors: Kunimura Kazufumi , Fukui Yoshinori 
Published: September 2021

Abstract
Atopic dermatitis (AD) is one of the most prevalent chronic inflammatory skin diseases in the world. It is characterized by recurrent eczematous lesions and intense itch, and many cytokines are involved in the pathogenesis of AD. Among them, much attention has been paid to interleukin 31 (IL-31) as an AD-associated itch mediator. IL-31 is mainly produced by CD4+ helper T cells and transmits the signals via a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor (OSMR), both of which are expressed in dorsal root ganglion (DRG) neurons. However, the molecular mechanisms of how IL-31 is produced in helper T cells upon stimulation and transmits the itch sensation to the brain were largely unknown. Recently, by using original mouse models of AD, we have identified endothelial PAS domain 1 (EPAS1) and neurokinin B (NKB) as key molecules critical for IL-31 production and IL-31-mediated itch transmission, respectively. These molecules could be novel drug targets for AD-associated itch. This review highlights our recent findings, which show the functional significance of these molecules in the IL-31-induced itch sensation, referring to their application to drug development.