bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Research Trends in Stem Cells for Tendon from 1991 to 2020: A Bibliometric and Visualized Study
Authors: Long Huibin , Yuan Ziyang , Yin Heyong , Yang Bo , Guo Ai 
Published: October 2021

Abstract
Background: Tendinopathy is a disabling musculoskeletal disorder affecting the athletic and general populations. There have been increased studies using stem cells in treating tendon diseases. The aim of this bibliometric and visualized study is to comprehensively investigate the current status and global trends of research in stem cells for tendon. Methods: Publications related to stem cells for tendon from 1991 to 2020 were retrieved from Web of Science. The source data were studied and indexed using a bibliometric methodology. VOS viewer software was used to conduct for the visualized study, including bibliographic coupling, co-authorship, co-citation and co-occurrence analysis and to analyze the publication trends of research in stem cells for tendon. Results: In total, 2492 articles were included. Though the relative research interests decline since 2018, the number of publications increased annually worldwide. The United States made the largest contribution to this field, with the most publications, citations and the highest H-index. The most contributive institutions were University of Pittsburgh, Zhejiang University, Shanghai Jiao Tong University and Chinese University of Hong Kong. The Journal of Orthopaedic Research published the most relative articles. Studies could be classified into five clusters: “animal study”, “tissue engineering”, “clinical study”, “mechanism research” and “stem cells research”, which show a trend of balanced development in this field. Conclusions: The number of publications on stem cells in treating tendon diseases may have reached a platform based on current global trends. The United States made the largest contribution to this field. In addition, according to the inherent changes of hotspots in each cluster and the possibilities of cross-research, the research in stem cells for tendon may exist a balanced development trend.
An Efficient Microwave-Assisted Synthesis Method of Novel Bi2O3 Nanostructure and Its Application As a High-Performance Nanocatalyst in Preparing Benzylidene Barbituric Acid Derivatives
Authors: Yahyazadehfar Mahdieh , Sheikhhosseini Enayatollah , Ahmadi Sayed Ali , Ghazanfari Dadkhoda 
Published: October 2021

Abstract
In this study, controllable and optimal microwave irradiation has been used to synthesize the novel nanostructures of Bi2O3 under environmental conditions. The final products had a thermal stability of 210 °C, an average particle size distribution of 85 nm, and surface area of 783 m2/g. The high thermodynamic stability of Bi2O3 nanostructures were confirmed by TG and DSC analyses. The nanostructure nature of compounds, most importantly, the use of effective, cost effective and rapid synthesis route of microwave have created significant physiochemical properties in the Bi2O3 products. These unexpected properties have made the possibility of potentials application of these products in various fields, especially in nanocatalyst applications. It is well-documented that, as Lewis acid, bismuth nanocatalyst exhibits a great catalytic activity for the green synthesis of some bio-active barbituric acid derivatives using precursors with electron-donating or –withdrawing nature in high yields (80-98%). After incorporating this catalyst into the aqueous media, all the reactions were completed within 2-3 min at room temperature. The main advantages of this method are practical facility, the availability of starting materials, and low costs besides the catalyst reusability. Additionally, the catalyst synthesis process may be carried in the aqueous media during a short period with medium to high yields. The obtained results have opened a new window for development of a novel nanocatalyst with practical application.
Correlations Among Ultrasonographic, Physicochemical and Sensory Characteristics of Pectoralis Major Muscles in Turkeys Reared in a Sustainable Farming System
Authors: Schwarz Tomasz , Węglarz Andrzej , Andres Krzysztof , Wojtysiak Dorota , Murawski Maciej , Ahmadi Behnaz , Bartlewski Pawel. M. , Ahmadi Bahareh 
Published: October 2021

Abstract
Background: One of the challenges of the contemporary meat industry is to obtain reliable information on meat quality throughout the entire production cycle. Previous studies have shown that computerized analysis of muscle ultrasonograms is a promising method to predict certain characteristics of skeletal muscles in live birds. Methods: The present study set out to examine associations among echotextural, physicochemical and sensory attributes of the pectoralis major muscles in 17-week old (B.U.T.) Big-6 turkeys raised in a sustainable farming system, and varying in the amount of wheat and oat grain in daily feed rations (Group C: complete feed only; Group Exp 1: 5 to 30% of wheat and 0 to 20% of oat; and Group Exp2: 5 to 50% of wheat and 0 to 50% of oat; n = 15 turkeys/group). Digital ultrasonograms of the left pectoral muscle in four different planes (longitudinal-L, transverse-T, and two oblique planes-O1 and O2) were obtained with a 5.0-MHz linear-array transducer just before slaughter. First-order echotextural variables (mean numerical pixel intensity-MPI and pixel heterogeneity-MPH) of the muscle parenchyma were computed using the ImageProPlusâ analytical software. Physicochemical and sensory attributes of the pectoral muscles were determined using validated laboratory and analytical methods. Results. Twelve significant correlations between echotextural attributes and various meat characteristics were recorded in Group C, one in Group Exp1, and eight in Group Exp2. When data were pooled for all birds studied, there were twelve significant correlations (P < 0.05); all but one correlation (between MPH and moisture) were for physical and sensory characteristics of meat samples. The strongest overall correlation was between O1-MPH and aroma (intensity) (r = -0.41, P = 0.005). Conclusion: Computer-assisted analysis is a potential method to determine certain chemical constituents (mainly moisture) as well as physical (e.g., coloration) and sensory (e.g., aroma) characteristics of pectoralis major muscles in organic turkeys. The occurrence and strength of quantitative correlations among echotextural characteristics in situ and post-mortem traits of turkeys’ muscles are affected by nutrition and scanning plane.
The Effect of Shock Duration on Trauma-Induced Coagulopathy in a Murine Model
Authors: Sloos Pieter , Maas M. Adrie W. , Hollmann Markus W. , Juffermans Nicole P. , Kleinveld Derek J.B. 
Published: October 2021

Abstract
BackgroundTrauma-induced coagulopathy (TIC) is a life-threatening condition associated with high morbidity and mortality. TIC can present with different coagulation defects. In this study, the aim was to determine the effect of shock duration on TIC characteristics. We hypothesized that longer duration of shock leads to a more hypocoagulable rotational thromboelastometry (ROTEM) profile compared to a shorter duration of shock.Methods|Male B57BL/6J(c) mice (n=5 to 10 per group) were sedated and mechanically ventilated. Trauma was induced by bilateral lower limb fractures and crush injuries to the liver and small intestine. Shock was induced by blood withdrawals until a mean arterial pressure of 25-30 mmHg was achieved. Groups reflected trauma and shock for 30 min (TS30) and trauma and shock for 90 min (TS90). Control groups included ventilation only (V90) and trauma only (T90).Results Shock groups had increased base deficit compared to control groups (V90 and T90). Mortality was 10% in TS30 and 30% in TS90. ROTEM profile was more hypocoagulable, as shown by significantly lower maximum clot firmness (MCF) in the TS30 group (43.5 [37.5 – 46.8] mm) compared to the TS90 group (52.0 [47.0 – 53.0] mm, p=0.008). ROTEM clotting time and parameters of clot build-up did not significantly differ between groups.ConclusionsTIC characteristics change with shock duration. Contrary to the hypothesis, a shorter duration of shock was associated with decreased maximum clotting amplitudes compared to longer duration of shock. The effect of shock duration on TIC should be further assessed in trauma patients.
Effect of Inhibited T lymphocyte Function on Depressive Symptoms in Breast Cancer Patients with Depression
Authors: Zhou Jun-He , Li Wei-Han , Zhang De-Long , Ning Bai-Le , Zhao Lin , Liu Ming , Fu Wen-Bin 
Published: October 2021

Abstract
Background: Depression has a high incidence among patients with breast cancer, but the relationship between depression and cancer-related physiological changes is not clear.Objectives: To explore the effect of T lymphocytes on breast cancer depression and the patient’s quality of life.Methods: This is a cross-sectional study. A total of 93 breast cancer patients with depression were recruited, 46 of whom underwent T lymphocyte, cortisol, BDNF, TNF-α, and IL-1β collection. We analysed the correlation between the indicators in these 46 participants and constructed two intermediary structural equations between their T lymphocytes and depression, as well as their T lymphocytes and their quality of life.Results: The results showed that CD4+ had a positive correlation with BDNF (r=0.334, P=0.023) and that BDNF had a negative correlation with HAMD-24 (r=-0.390, P=0.007). Both CD3+ and CD8+ cells were negatively correlated with cortisol (r=-0.358, P=0.015, r=-0.411, P=0.005), and cortisol was positively correlated with FACT-B (r=0.435, P=0.003). The equations including CD4+, BDNF, and HAMD-24, as well as the equations including CD3+, CD8+, cortisol, and FACT-B, were established. BDNF was the mediating variable between CD4+ and HAMD-24. Cortisol was the mediating variable between CD3+, CD8+ and FACT-B. Neither HAMD-24 nor FACT-B could form a direct path with T lymphocytes.Conclusion: T lymphocytes may be involved in the depression of breast cancer patients since a poor quality of life could inhibit T lymphocytes, and this may be the underlying physiological cause of breast cancer-related depression.
Copy Number Variations Contribute to Intramuscular Fat Content Differences By Affecting The Expression of PELP1 Alternative Splices in Pig
Authors: Wang Ligang , Zhang Tian , Na Li , Zhang Longchao , Hou Xinhua , Yan Hua , Wang Lixian 
Published: October 2021

Abstract
Background Intramuscular fat (IMF) is a key meat quality trait. Research on the genetic mechanisms of IMF decomposition is valuable for both pork quality improvement and the treatment of obesity and type 2 diabetes. Copy number variations (CNVs) are a type of variant that may influence meat quality.ResultsIn this study, a total of 1185 CNV regions (CNVRs) including 393 duplicated CNVRs, 432 deleted CNVRs, and 361 CNVRs with both duplicated and deleted status were identified in a pig F2 resource population using next-generation sequencing data. A genome-wide association study (GWAS) was then performed between CNVs and IMF, and a total of 19 CNVRs were found to be significantly associated with IMF. QTL colocation analysis indicated that 3 of the 19 CNVRs overlapped with known QTLs. RNA-seq and qPCR validation results indicated that CNV150, which is located on the 3’UTR end of the proline, glutamate, and leucine rich protein 1 (PELP1) gene, may affect the expression of PELP1 alternative splices. Sequence alignment and Alphafold2 structure prediction results indicated that the two alternative splices of PELP1 have a 23 AA sequence variation and a helix-fold structure variation. This region is located in the region of interaction between PELP1 and other proteins which have been reported to be significantly associated with fat deposition or insulin resistance. We infer that the CNVR may influence IMF content by regulating the alternative splicing of the PELP1 gene and ultimately affecting the structure of the PELP1 protein. ConclusionsIn conclusion, we found some CNVRs, especially CNV150, located in PELP1 that affect IMF. These findings suggest a novel mechanistic approach for meat quality improvement in animals and potential treatment of insulin resistance in human beings.
Simulation and Experiment Research on Liquid Channel of Diffuser Blade by Electrochemical Machining
Authors: Xu Jinkai , Tao Jin , Ren Wanfei , Tian Kun , Sun Xiaoqing , Yu Huadong 
Published: October 2021

Abstract
Aiming to solve the problems of the low electrolyte flow rate at leading edge and trailing edge and poor uniformity of the end clearance flow field during the electrochemical machining (ECM) of diffuser blades, a gap flow field simulation model was established by designing three liquid-increasing channels at the leading edge and the trailing edge of the cathode. The simulation results indicate that the liquid-increasing hole channel (LIHC) with an outlet area S of 1.5 mm2 and a distance L from channel center to edge point of 3.2 mm achieves optimal performance. In addition, the experiment results show that the optimized cathode with liquid-increasing hole channel (LIHC) significantly improves the machining efficiency, accuracy and surface quality. Specifically, the feed speed increased from 0.25 mm/min to 0.43 mm/min, the taper decreased from 4.02° to 2.45°, the surface roughness value of blade back reduced from 1.146 µm to 0.802 µm. Moreoever, the roughness of blade basin decreased from 0.961 µm to 0.708 µm, and the roughness of hub reduced from 0.179 µm to 0.119 µm. The results prove the effectiveness of the proposed method, and can be used for ECM of other complex structures with poor flow field uniformity.
Access To WASH, Knowledge, Practice, and Protective Motivation Behaviour Towards COVID-19 Pandemic of Urban Marginalized Peoples
Authors: Pattanrsi Siwarat , Nguyen Thi Phuoc Lai 
Published: October 2021

Abstract
Background

Urban marginalized people are most vulnerable to the Covid-19 pandemic because of their poor water and hygiene conditions and high-density populated environment. However, there lack WASH facilities and theory-guided behavioural health intervention programs towards the Covid-19 pandemic in these fragile communities.
Methods

This study used the combined Knowledge- Practice -Theory (KAP) and Protection Motivation Theory (PMT) to predict the protective motivation behaviours of urban marginalized people against Covid-19. The phenomenological approach was applied to examine the slum communities' lived experiences during the COVID-19 pandemic. Data was collected through 105 semi-structured interviews and 453 questionnaires in two slum communities in Bangkok, Thailand.
Results

Results showed that most Thai slum people tended to have better access WASH and healthcare services and protection behaviours towards Covid-19 than other foreign migrant slum people. Structural Equation Modelling results illustrated that knowledge directly drove marginalized peoples’ perceived vulnerability and practices, while practices influenced their perceived severity, self, and response efficacy which directly associated with their behavioural intentions.
Conclusions

Future pandemic prevention intervention programs should focus on vulnerability and severity through providing adequate WASH facilities and self-efficacy and response efficacy of protection motivation through enhancing community sensitization and awareness of COVID-19 protection.
Plumbagin Protects H9c2 Cardiomyocytes against TBHP-induced Cytotoxicity via Alleviating ROS-induced Apoptosis and Inducing Autophagy
Authors: Zhang Qianrui , Fu Haitan , Gong Wenjuan , Cao Feng , Wu Tao , Hu Fei 
Published: October 2021

Abstract
Plumbagin has been previously reported to alleviate myocardial ischemia/reperfusion injury in vivo. In this study, we analyzed the potential role of plumbagin against hydrogen peroxide-induced injury in cardiomyocytes. In the present study, plumbagin (PLB) was used to evaluate its cytoprotective property in H9c2 cardiomyocytes against tertiary butyl hydrogen peroxide (TBHP, 75 μM) induced ROS-mediated oxidative stress and apoptosis. Our results implicate that pretreatment with PLB (5, 10 or 20 μM) notably restored viabilities in TBHP-induced H9c2 cells (p＜0.01). Also PLB treatment significantly decreased creatine kinase (CK) (p＜0.01) and lactate dehydrogenase (LDH) activity (p＜0.01). TBHP induced apoptosis and oxidative stress in cultured cardiomyocyte, whereas PLB pretreatment significantly reduced TBHP-induced apoptosis rate (p＜0.01) and ROS level (p＜0.01). Furthermore, PLB resulted in decrease in the expressions of cleaved caspase 3, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme 4 (NOX4) and phospho-p38 MAPK in TBHP-induced H9c2 cells. And the active marker of autophagosomes, LC3-II/LC3-I was elevated following treatment with PLB. These findings indicated that PLB may induce autophagy. The present study shows the protective role of PLB against TBHP-induced cardiomyocyte injury via alleviation of ROS-mediated apoptosis and induction of autophagy.
Efficient Adsorptive of Carbofuran Via Tailored Porous Polyacrylonitrile Film Incorporated Ti-MIL Coordination Polymer
Authors: Albaqami Munirah D. , Alobaid Amal O. , nafady Ayman 
Published: October 2021

Abstract
Carbofuran is largely applied insecticide which resulted in its wide spreading in ground/surface water and food products and consequently investigation of efficient techniques for removal of carbofuran is extensively considered. Herein, facile approach for removal of carbofuran was developed via exploitation of highly adsorptive porous film based on polyacrylonitrile (PAN) and NH2-MIL-Ti as a coordination polymer. NH2-MIL-Ti@P-PAN film was prepared by immobilization of NH2-MIL-Ti within the pre-prepared porous (P-PAN) film. The pore diameter of PAN film was estimated to be 8.5 – 51.2 µm. The removal of carbofuran from the porous film was systematically studied and fitted to both pseudo 2nd ordered and Langmuir models. Results showed that Langmuir maximum removal of carbofuran was largely enhanced from 292.2 mg/g for P-PAN to 489.5 – 690.1 mg/g for NH2-MIL-Ti@P-PAN. Thus, by increasing the amount of immobilized NH2-MIL-Ti@P-PAN in the film, the adsorption capacity of carbofuran was markedly improved, reaching a 2.4 times higher when 30% NH2-MIL-Ti is immobilized. Importantly, after six reusing times, the removal of carbofuran by 30% NH2-MIL-Ti@P-PAN film was decreased by only 12.5%. The overall results attest that the fabricated NH2-MIL-Ti@P-PAN film could be efficiently used for trace removal of various insecticides and other environmental applications.
Robust Stabilization of T-S Fuzzy Systems via Improved Integral Inequality
Authors: C Karthik , G Nagamani , Subramaniyam Ramasamy , D Dafik 
Published: October 2021

Abstract
This paper focuses on the state feedback control for uncertain nonlinear model, which can be denoted by Takagi - Sugeno (T-S) fuzzy model. We derive an improved integral inequality as a rearrangement of quadratic matrix-vector form combined with Jensen's inequality. By using this improved inequality, the sufficient conditions guaranteeing the stability of the resulting T-S fuzzy model have been proposed in terms of linear matrix inequalities. With respect to these stability conditions, the stabilization criterion is given for the T-S fuzzy systems with the prescribed control gain matrices. Finally, to check the feasibility and less conservatism of the derived results, numerical examples are given including the physical model such as continuous stirred tank reactor ( CSTR ) model supported by numerical simulations.
Exploration of the Diagnostic Classification of Orthorexia Nervosa: Distinct Disorder, Anorexia Nervosa or Obsessive-Compulsive Disorder?
Authors: Cosh Suzanne M , Olson Jemma , Tully Phillip J. 
Published: October 2021

Abstract
PurposeOrthorexia Nervosa (ON) is characterised as obsessional healthy eating that results in malnutrition and/or psychosocial impairment. Yet, its diagnostic classification remains uncertain, with theoretical overlap with Anorexia Nervosa (AN) and Obsessive-Compulsive Disorder (OCD). This study aimed to further understand appropriate diagnostic classification by assessing the ability of ON for detecting the presence/absence of AN and OCD.MethodAn observational survey was completed by 362 participants recruited through eating-disorder, dieting and mental health support groups. Receiver Operating Characteristics (ROC) curve analyses determined the predictive ability of ON symptoms (assessed by ORTO-15 and ORTO-9) for detecting AN (determined by EAT-26 cut-scores and BMI >17.5), and OCD and Obsessional thinking (assessed by the OCI-R).ResultsResults showed both ON measures are able to adequately predict AN, however ON was poor to moderate at detecting OCD and Obsessional thinking. Specificity for detecting AN was poor and ability to discriminate between AN and ON was low.ConclusionThese results suggest that ON, as it is currently measured, may be more closely related to EDs than OCD, and that ON may represent a subtype or subset of AN; although results are limited by the lack of definitive ON diagnostic criteria and limitations of ON measures.Level of evidence – Level V, cross-sectional descriptive study
Microstructure Dependent Dislocation Density Evolution in Micro-macro Rolled CNT/Al Composite
Authors: Sadeghi Behzad , Cavaliere Pasquale 
Published: October 2021

Abstract
Flake powder metallurgy combined with micro/macro rolling was employed to produce CNT/Al composites. The effect of deformation mode on the lamellar ultrafine grain structure and on the dislocation density was analyzed. Additionally, a model based on microstructure and processing parameters is proposed to analyze the effect of size, aspect ratio and crystallography texture of the matrix grains on dislocation density. It was shown that the dislocation density depends on CNTs dispersion degree and CNT-aluminum interfacial bonding level as a consequence of micro rolling process, as well as on the grain refinement, crystallography texture, and high aspect ratio resulted from macro-rolling process. It was demonstrated that the micro/macro rolling process provides the lamellar ultrafine grains with higher dislocation storage capability with respect to equiaxed grains. The described process indicated that it could provide good combination between the CNTs dispersion, CNT-aluminum interfacial bonding as well as crystallography texture, size and shape of the matrix grains.
Effects of Different Viscometer Test on Stencil Printing Process for CFD Simulation
Authors: Ishak Mohammad Hafifi Hafiz , Rusdi Mohd Syakirin , Abdullah Mohd Zulkifly , Aziz Mohd Sharizal Abdul , Abdullah Muhammad Khalil , Rethinasamy Parimalam , Santhanasamy Damian G. 
Published: October 2021

Abstract
This study discusses the use of different spindle type for the testing of lead-free solder paste by using Computational Fluid Dynamics (CFD) simulation. The study focuses on measuring the volume of solder paste deposition on the solder pad. Parallel-plate (PP) and Cone-plate (CP) spindle were used with five different tests consist of different spindle type and setting. The Volume of Fluid (VOF) method was used for the simulation while Cross model was applied as viscosity model for the solder paste. SAC305 type 3 lead-free solder paste was used in this study as it is mostly popular used by the industries nowadays. The solder paste filled the volume under different squeegee speeds and aperture size was compared between experiments and simulations. For different squeegee speed, PP 0.5 mm gap obtained the lowest average discrepancy value between simulation and experimental results. At different aperture size, all test show similar trend line and about the same value of average discrepancy with CP1° while PP 0.5 mm gap showed the lowest average discrepancy. At small aperture volume, all tests performed shows similar value of filled volume except PP 0.5 mm which exhibit the lowest percentage difference when compared with the experimental values at a bigger aperture volume.