bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological characteristics of invasive stratified mucinous carcinoma of the cervix and the expression and clinical significance of SLC7A11, SLC3A2 and PD-L1
Authors: Lu Changyu , Zhu Wei , Han Xiahui , Du Xiuzhen , Zhang Hui , Yao Qin , Liu Ting , Zhang Ce 
Published: December 2024

IntroductionInvasive Stratified Mucin-producing Carcinoma (ISMC) of the cervix is a newly named cervical adenocarcinoma associated with Human Papilloma virus (HPV). Due to its relative rarity, clinical data, pathological features, and molecular characteristics of ISMC are still under exploration. This study aims to retrospectively analyze the clinical data and pathological features of ISMC patients, summarizing the clinical and pathological morphological characteristics of ISMC. Immunohistochemistry for SLC7A11, SLC3A2, and PD-L1 will be performed on tumor tissues from ISMC patients to preliminarily explore potential therapeutic targets for ISMC.MethodsWe retrospectively reviewed the electronic medical records and pathological slides of 22 ISMC patients, and performed immunohistochemical staining for solute carrier family 7 member 11 (SLC7A11), solute carrier family 3 member 2 (SLC3A2), and programmed death-ligand 1 (PD-L1).ResultsThe patients were aged between 31 and 70 years old. The most common symptoms were abnormal vaginal bleeding and unusual vaginal discharge. HPV testing indicated that the infection rate of HPV type 18 was the highest. All patients underwent extensive hysterectomy and pelvic lymph node dissection. The progression-free survival (PFS) ranged from 3 to 112 months, with a postoperative recurrence rate of 22.7% (5/22). ISMC exhibited diverse characteristic microstructures. Immunohistochemistry results showed that the positive rates of SLC7A11 and SLC3A2 were both 91.0% (20/22). The staining intensity of SLC7A11 in frequent ISMC recurrence cases was significantly stronger than in non-recurrent ISMC cases. PD-L1 positivity was observed in 86.4% (19/22) of cases, defined as having a Combined Positive Score(CPS)≥1.DiscussionISMC demonstrates a high rate of lymph node metastasis and a high recurrence rate, indicating strong invasiveness. Additionally, ISMC exhibits a wide morphological spectrum. SLC7A11, SLC3A2, and PD-L1 are all highly expressed in ISMC tissues. The high expression of SLC7A11 may indicate a high recurrence rate for ISMC. Immunotherapy with checkpoint inhibitors and iron death-related treatments show potential in the treatment of ISMC, with SLC7A11, SLC3A2, and PD-L1 serving as potential therapeutic targets for ISMC.
La programación de la enseñanza y sus escrituras en la formación docente universitaria
Authors: Molina María Elena 
Published: December 2024

La programación de la enseñanza incluye un conjunto de procedimientos y prácticas cuya finalidad reside en llevar a cabo las intenciones pedagógicas. Dentro de esos procedimientos y prácticas, los géneros vinculados con la programación de la enseñanza (GPE) —planificaciones de clases, secuencias didácticas, programas de asignaturas, entre otros— devienen centrales. Sin embargo, pese a la importancia de estos escritos en la agenda de la didáctica y de la formación docente, existe un vacío de investigaciones vinculadas con los modos en los que estas prácticas se enseñan como géneros. Con frecuencia, las indagaciones se concentran en los componentes de las programaciones, en tanto categorías teóricas de la didáctica, pero no abordan las modalidades en las que estas se trabajan en los espacios de formación. Desde un enfoque mixto, este artículo analiza cómo se trabajan los GPE en 66 asignaturas de formación pedagógica de una universidad pública argentina. Los resultados muestran que existen tres formas de incluir el trabajo con los GPE: (1) inclusión nula (los GPE no aparecen mencionados en los programas de las asignaturas de formación docente); (2) inclusión tangencial (los GPE se trabajan en las asignaturas, pero como pedidos extras, lecturas complementarias o escritos alternativos a otros géneros científico-académicos); y (3) inclusión vertebral (los GPE se entienden como prácticas centrales para la formación docente y se los incorpora en las construcciones metodológicas de las asignaturas).
Sobre Historia y Educación
Authors: Dono Rubio Sofía 
Published: December 2024

Antonio Viñao Frago es uno de los más prestigiosos historiadores de la educación contemporáneos, referente de la disciplina en España y en el mundo, con una profusa obra que consta de veinte libros de autoría propia, doce trabajos colectivos en los que fue editor o coordinador, y algo más de trescientos artículos y capítulos de libros. En su vasta producción, ha recorrido con rigurosidad y originalidad un abanico muy amplio de temas que abarcan los orígenes del sistema educativo español y la escuela graduada, la educación secundaria, la alfabetización y la cultura escrita, la cultura material de la escuela, la memoria escolar y el patrimonio educativo, las disciplinas y la manualística escolar, el tiempo y espacio escolar, memorias del profesorado, entre otras.
Las preguntas se organizaron en torno a dos tópicos, uno vinculado a recuperar reflexiones en torno a la perspectiva historiográfica y otro que busca ahondar en sus consideraciones sobre algunas temáticas en las que nuestro entrevistado ha trabajado.
El contenido de la entrevista fue resultado de una serie de conversaciones mantenidas con el Prof. Viñao durante una estancia académica realizada en el Departamento de Teoría e Historia de la Educación de la Universidad de Murcia durante el mes de diciembre de 2023. Posteriormente el material fue revisado y ampliado por el entrevistado.
Практические аспекты ухода за кожей вульвы при склероатрофическом лихене
Authors: Валуевич Т.В. , Крук Н.И. , Рабчинская О.М. 
Published: December 2024

Склероатрофический лихен представляет собой распространенный воспалительный дерматоз аногенитальной области, который встречается во всех возрастных группах. Заболевание оказывает существенное влияние на качество жизни, в большинстве случаев сопровождаясь выраженным зудом и болью, приводит к рубцеванию и повреждению архитектоники наружных половых органов, нарушая процесс мочеиспускания, дефекации, вызывая сексуальную дисфункцию и увеличивая риск малигнизации. Данная статья посвящена практическим аспектам ухода за кожей вульвы, направленным на поддержание целостности кожного барьера, облегчение симптомов и улучшение качества жизни женщин со склероатрофическим лихеном. Рассмотрены современные подходы и рекомендации по интимной гигиене, а также уделено внимание профилактическим мерам и важности индивидуального подхода. Повышение осведомленности среди врачей разных специальностей и общественности об этом заболевании и эффективных методах лечения является критически важным для его ранней диагностики и предотвращения развития осложнений.
Lichen sclerosus is a common inflammatory dermatosis of anogenital area, which occurs in all age groups. It has a significant impact on the quality of life, in most cases accompanied by severe itching and pain, leads to scarring and architectural changes of the external genitalia, disrupting the process of urination and defecation, causing sexual dysfunction and increasing the risk of malignancy. This article focuses on the practical aspects of vulval skin care, aimed at preserving the integrity of the skin barrier, alleviating symptoms, and improving the quality of life in women with lichen sclerosus. Modern approaches and recommendations for intimate hygiene have been reviewed, emphasizing preventive measures and the importance of an individualized approach. Raising awareness of this disease and effective methods of treatment among healthcare professionals and the general population is crucial for early diagnosis and prevention the development of complications.
Пути изучения гонореи в России (Х – первая половина ХХ в.)
Authors: Заславский Д.В. , Белова Л.В. , Таганов А.В. 
Published: December 2024

Цель. Проанализировать малоизвестные факты и аспекты изучения гонореи в России (Х – первая половина ХХ в.). Материалы и методы. Изучение научных трудов и докладов, изданий периодической печати, воспоминаний современников указанного периода. Обсуждение. Восполнен пробел в историко-медицинской литературе. Доказана актуальность и крайняя важность знаний в отношении гонореи. Проведен анализ методов лечения и диагностики гонореи российскими учеными и врачами (Х – первая половина ХХ в.). Выводы. Фундаментальные труды русских ученых и врачей в контексте изучения гонореи заслуживают высокой оценки, являются не только достоянием российской медицины в историческом аспекте, но и важным медицинским наследием для следующих поколений.
Purpose. To analyse little-known facts and aspects of the study of gonorrhoea in Russia (X – the first half of the twentieth century). Materials and methods. Study of scientific papers and reports, periodicals, memoirs of contemporaries of the mentioned period. Discussion. The gap in the historical-medical literature is filled. The urgency and extreme importance of knowledge about gonorrhoea is proved. The methods of treatment and diagnostics of gonorrhoea by Russian scientists and doctors (X – the first half of the XX centuries) have been analysed. Conclusions. Fundamental works of Russian scientists and doctors in the context of gonorrhoea study deserve high estimation, are the property of Russian medicine not only in historical aspect, but also is an important medical heritage for the next generations.
Enfermedad de Pott, reto diagnóstico y terapéutico: reporte de caso
Authors: Celis Violeta , Ibañez-Reluz Miguel 
Published: December 2024

Tuberculosis (TB) still is a significant public health problem, with high morbidity and mortality. When it affects the spine, it is called Pott's disease or spinal tuberculosis (STB). Early diagnosis and treatment are essential for preventing serious complications and improving both prognosis and quality of life. In this report, we present two cases of STB in which there were confounding factors in the initial diagnostic approach. In the first case, the unusual presentation led to a delay in diagnosis. In the second case, an intercurrent condition complicated reaching a timely diagnosis. This led to profound consequences in the first case. Local difficulties for achieving timely diagnosis and treatment are also discussed. STB should be suspected in all cases of chronic axial pain, especially when there is a history of contact with infected people in the household. Public and private health facilities in Peru should develop and implement diagnostic protocols adapted to available human and technical resources and ensure effective and timely administration of anti-tuberculosis chemotherapy.
التحول الرقمي في المصارف وأثره في ابعاد التدقيق التسويقي: دراسة تحليلية لآراء عينة من المصارف التجارية الحكومية والاهلية في محافظة النجف الاشرف للمدة 2023-2024
Authors: كاظم سمر عبد الرحمن , سماكة علي محمود 
Published: December 2024

يهدف البحث الحالي الى التعرف على مفهوم دورة حياة المصرف ومدى تأثيرها على الأداء المالي في عينة من المصارف العراقية ولغرض تحقيق اهداف الدراسة اعتمدت الباحثة على كلاً من المنهجين الاستنباطي والاستقرائي، كما تمت الاستعانة في الجانب التطبيقي بمجموعة من النسب المالية لاستخراج نتائج البيانات والتي تم جمعها من التقارير السنوية للمصارف التجارية عينة الدراسة، ومن ثم تمت المقارنة بين الفترات الزمنية لهذه المصارف وذلك لغرض الوقوف على واقع الاداء ومعرفة تركيبة الهيكل المالي في المصارف التجارية المدرجة في سوق العراق للأوراق المالية. وكذلك عتمدت الباحثة اعتمد الباحثة على عدد من الأساليب الإحصائية spss v.28 لمعرفة تأثير دورة حياة المصرف على الأداء المالي
وقد توصل البحث الى مجموعة من الاستنتاجات اهما ان جميع مراحل دورة حياة المصرف اذا ما تم اخذها مجتمعة تؤثر بشكل معنوي من الناحية الاحصائية في الاداء المالي، ومن خلال ذلك يمكن ان يتم استنتاج ان أداء الشركة المالي يتأثر من خلال دورة الحياة كون المرحلة العمرية للشركة تحتم على إدارة الشركة توجيه مواردها نحو تحقيق أهدافها فضلا عن بقائها في سوق العمل واستمراريتها وهو ما ينعكس في أدائها المالي.
Evidências Recentes da Síndrome do Impacto no Ombro
Authors: Paluan Angelo Nascimento , Perdigão Tiago Freitas Brito , Morais Vitor Soares de , Sousa Arthur Alves de , Sousa Gabriel Alves de 
Published: December 2024

A síndrome do impacto no ombro (SIO) é uma condição inflamatória e degenerativa caracterizada pela compressão mecânica de estruturas no espaço umerocoracoacromial. Comumente afeta indivíduos entre 40 e 50 anos, mas também ocorre em adultos jovens devido a atividades laborais e esportivas. A SIO é a afecção mais prevalente da cintura escapular. Diagnóstico precoce e tratamento adequado são essenciais para prevenir a progressão da doença. Este estudo apresenta evidências recentes, modelos de tratamento, destacando a fisioterapia e a parte da ortopedia no manejo conservador da SIO. Foi realizada uma revisão da literatura científica abrangendo livros e artigos de periódicos nacionais e internacionais. O tratamento conservador da SIO inclui analgésicos, anti-inflamatórios e fisioterapia, sendo esta última crucial para a recuperação funcional. A fisioterapia não apenas alivia a dor e melhora a mobilidade, mas também educa os pacientes sobre posturas e atividades a serem evitadas. Técnicas como terapia manual, exercícios de fortalecimento e estabilização, e modalidades eletroterápicas têm mostrado eficácia significativa. A abordagem conservadora é amplamente utilizada e eficaz, com a fisioterapia sendo a modalidade mais indicada. A escolha do tratamento deve ser personalizada, considerando a fase da doença e a resposta do paciente. Nos casos em que o tratamento conservador não é suficiente, a cirurgia pode ser considerada. Um plano de tratamento multifacetado pode otimizar os resultados e melhorar a qualidade de vida dos pacientes com SIO.
Complicações da Sífilis Gestacional e a Importância do Pré-Natal Adequado
Authors: Santos Elaíne Apolinário dos , Silva Pedro Augusto Barbosa , Aguiar Giovanna Maria Lemos , Duarte Geovana Mancini dos Santos , Santos Daniel Wesley Teodoro , Provin Larissa Luana , Souza Priscila da Silva , Rodrigues Victoria Karolline Silva , Silva Nathalia Vitória da , Schaefer Fernanda Mayta , Santos Ana Karolline Viana , Ferraz Leonardo Augusto 
Published: December 2024

Introdução: O Treponema pallidum é uma bactéria responsável por causar a sífilis. Essa condição pode ser transmitida por via sexual, sanguínea e vertical. A sífilis gestacional, se não realizada o tratamento adequado, pode acarretar em repercussões materno-infantil. A sífilis congênita é uma condição onde o feto já está infectado por essa transmissão vertical, possibilitando um aumento da morbimortalidade. O pré-natal adequado é recomendado para prevenção dessas condições. Objetivo: Analisar a possíveis complicações que a sífilis gestacional pode acarretar, além de analisar a importância do pré-natal adequado para prevenção dessas complicações. Método: Trata-se de uma revisão integrativa dos últimos 5 anos, do período de 2019 a 2024, utilizando as bases de dados da Literatura Latino–Americana e do Caribe em Ciências da Saúde (LILACS) e BDENF. Os descritores utilizados foram: "pré-natal" "adequado" "prevenção". Foram encontrados 33 artigos, sendo eles submetidos aos critérios de seleção. Os critérios de inclusão foram artigos que se relacionavam à proposta estudada e que foram disponibilizados na íntegra. Os critérios de exclusão foram relatos de caso, artigos que não se relacionavam à proposta estudada e que foram disponibilizados na forma de resumo. Resultados e Discussão: A SG requer intervenção imediata, no intuito de reduzir a transmissão para o feto. Nesse sentido, a identificação, por meio do acompanhamento pré-natal adequado, no mínimo 6 consultas, é importante para o rastreamento dessa condição e, se identificado, iniciado o tratamento, com objetivo de impedir a infecção fetal, se ainda não infectado, ou se já infectado, minimizar os danos. Essa infecção pode acarretar em complicações como aborto, obito fetal, compromeitmento auditivo, fisico e visual. Conclusão: Nessa perspectiva, nota-se a importância do pré-natal para o rastreamento e tratamento dessa condição, auxiliando na redução da morbimortalidade. As complicações dessa infecção vão desde formas assintomáticas até o óbito fetal.
Cirurgia de ulectomia em paciente pediátrico com retardo eruptivo relacionado a incisivos centrais superiores permanentes: relato de caso.
Authors: Lins Sócrates de França , Alexandre Gabriel Ramos , Oliveira Gabriel Ronnier de Alencar , Ramos Camilla Beatriz , Santiago Andressa , Santos Rafaella Juliana Bezerra dos , Pinheiro Ana Luísa Miranda , Vasconcelos Rafaela Brito 
Published: December 2024

O processo de erupção dentária se inicia na fase embrionária, onde promove várias etapas até o seu completo irrompimento na cavidade oral. Durante a cronologia dentária, o dente pode ser influenciado por diversos fatores, entre eles, pode-se destacar a erupção tardia devido ao excesso do tecido gengival fibroso que recobre a região de coroa do dente. Sendo assim, faz-se necessária a cirurgia de ulectomia, o qual consiste na remoção da fibrose gengival dos dentes permanentes não erupcionados. O presente artigo tem como objetivo relatar um caso clínico de ulectomia em paciente pediátrico com retardo eruptivo em incisivos centrais permanentes. Paciente do sexo masculino de 7 anos de idade, compareceu à clínica de odontopediatria do centro Universitário Brasileiro-UNIBRA acompanhado pela responsável, com queixa de que os dentes anteriores “não nasciam”. Na anamnese, constatou-se ausência de alterações sistêmicas e não houve relato de fatores extrínsecos que pudessem resultar em tal retardo, como traumatismo dento alveolar local ou perda precoce do dente decíduo. Ao exame clínico, notou-se a presença de espessa faixa de tecido gengival com coloração mais pálida no elemento 11 e, ao toque, evidenciava-se que a coroa do dente não havia erupcionado. Para análise radiográfica do caso, foi realizada a técnica periapical modificada, assim como a panorâmica, onde foi possível observar a presença do elemento dentário correspondendo ao estágio 8 da classificação de Nolla, o que constata a real necessidade da cirurgia, uma vez que, mesmo com a formação radicular de ⅔ o dente não estava em boca. Após 19 dias de proservação, observou-se um adequado posicionamento do dente 11. Entretanto, este relato de caso teve como diferencial, a exodontia dos dentes 52 e 62, que foram necessárias para que houvesse abertura de espaço ao dente 21 irromper na cavidade oral. Conclui-se, com este caso, que a abordagem cirúrgica da ulectomia é eficaz para o tratamento dos elementos dentários retidos, a fim de possibilitar características estético-funcionais satisfatórias.
Nanoparticles of Kalakai Leaf (Stenochlaena Palustris) and Lemon (Citrus Limon) to Changes Hemoglobin, Erythrocyte and Hematocrit Levels in Adolescent Women
Authors: Oktadiarini Dwi , Isnawati Muflihah , Wahyuni Sri 
Published: December 2024

The prevalence of anemia increases every year, this must be welcomed with innovations in preventing anemia in adolescents so that it does not increase the rate of increase in cases of anemia in adolescents and even pregnancy. One way to treat anemia is to use kalakai and lemon leaves which are processed into nanoparticles. Kalakai leaves contain iron, vitamin C which functions to increase hemoglobin, erythrocyte and hematocrit levels. This research aims to analyze the effect of kalakai leaf and lemon nanoparticles on increasing hemoglobin, erythrocyte and hematocrit levels in adolescent girls. This type of research is true experiment with simple random sampling technique. The total sample was 34 anemic adolescent girls, 17 samples from the intervention group and 17 samples from the control group. This research used kalakai leaf nanoparticles (2g) and lemon (3g) combined together and given once a day for 14 days. The research was conducted at STIKes Borneo Scholar Medika. The administration of kalakai and lemon leaf nanoparticles can significantly increase hemoglobin levels with a p-value=0,000 and an effect size value of 0,66 (Modest Effect) and a percentage in the intervention group of 11,1%, erythrocytes with a p-value=0,000 and an effect size of 0,82 (Modest Effect) and the percentage in the intervention group was 23,4%, Hematocrit value was p=0,000 and the effect size was 0,60 (Modest Effect) and the percentage in the intervention group was 7,6%.
Enhancing Farmers’ Quality of Life through Social Trust: A Case Study of Karangpatihan Village, Indonesia
Authors: Prayitno Gunawan , Nugraha Achmad Tjachja , Ari Ismu Rini Dwi , Ichdayati Lilis Imamah , Purnomowati Rahmi , Fauziah Septia Hana , Subagiyo Aris , Najid Salsa Alifia , Salsabila Aulia Putri , Nisak Fajar Fadhilatun 
Published: December 2024

This study highlights the pivotal role of social trust in enhancing farmers’ quality of life (QoL) in Karangpatihan Village, Indonesia. Utilizing Structural Equation Modeling (SEM), the research examines the influence of social trust on various QoL dimensions, finding significant impacts across all aspects, with the strongest effect on health and safety. The results emphasize the importance of fostering social trust to bolster adaptive strategies, such as adopting innovative farming techniques, optimizing resource use, and encouraging collaboration among farmers. Strengthening social capital in rural agricultural communities is vital for ensuring food security and long-term economic resilience. This research contributes to the existing body of literature on social capital by identifying trust as a crucial determinant of QoL in rural settings. The findings carry substantial policy implications, indicating that initiatives aimed at building trust are essential for enhancing farmers’ well-being.
Optimisasi Hybrid Recommendation System dengan Clustering menggunakan Machine Learning
Authors: Handijono Ardijan , Suhatman Zaldy 
Published: December 2024

Bank seringkali menawarkan produk finansial yang bersifat generik dan kurang spesifik terhadap kebutuhan masing-masing nasabah, sehingga tingkat keberhasilan pemasaran produk finansial cenderung rendah dan kurang efektif. Penelitian ini bertujuan untuk mengoptimalkan sistem rekomendasi produk finansial dengan menerapkan hybrid recommender system yang mengintegrasikan teknik segmentasi nasabah berbasis machine learning. Segmentasi dilakukan melalui teknik clustering yang menggabungkan model RFM (Recency, Frequency, Monetary) dengan data demografis dan rata-rata saldo harian nasabah, menghasilkan segmentasi yang lebih akurat dan relevan dalam mengidentifikasi preferensi serta kebutuhan masing-masing segmen nasabah.Proses pengembangan model dilakukan dengan metodologi CRISP-ML(Cross-Industry Standard Process for Machine Learning) , menggunakan algoritma clustering K-Means dan DBSCAN. Hasil evaluasi menunjukkan bahwa algoritma DBSCAN memiliki performa yang lebih unggul dibandingkan K-Means dalam mengelompokkan nasabah sesuai karakteristik yang spesifik. Selain itu, penerapan machine learning memungkinkan model untuk memperbarui segmen secara real-time berdasarkan data transaksi terbaru, sehingga mampu beradaptasi dengan perubahan perilaku nasabah secara dinamis dan responsive. Recommender system kemudian dibangun berdasarkan produk-produk populer pada masing-masing segmen, dengan asumsi bahwa nasabah dalam segmen yang sama memiliki preferensi yang serupa. Sistem ini membantu bank mengidentifikasi peluang Cross-Selling dan Up-Selling secara lebih tepat sasaran. Hasil akhir dari penelitian ini adalah recommender system yang mampu memberikan rekomendasi produk yang sesuai dengan karakteristik demografis, seperti usia, jenis kelamin, pekerjaan, nilai RFM, dan rata-rata saldo harian nasabah, sehingga meningkatkan relevansi dan efektivitas penawaran produk serta kepuasan nasabah. Hasil penelitian menunjukkan bahwa sistem yang dibangun mampu meningkatkan efektivitas pemasaran dari 48% menjadi 78% dan kepuasan nasabah dari 65% menjadi 92%. Dengan segmentasi yang lebih akurat dan rekomendasi produk yang relevan, sistem ini memberikan pengalaman layanan yang lebih personal dan mendukung efisiensi pemasaran bank.

Kata Kunci: Hybrid Recommender System, Clustering, K-Means, DBSCAN, RFM , Bank