bluuebunny/crossref_metadata_2025_split huggingface dataset:
XENOBREAST Trial: A prospective study of xenografts establishment from surgical specimens of patients with triple negative or luminal b breast cancer
Authors: Veyssière Hugo , Passildas Judith , Ginzac Angeline , Lusho Sejdi , Bidet Yannick , Molnar Ioana , Bernadach Maureen , Cavaille Mathias , Radosevic-Robin Nina , Durando Xavier 
Published: June 2021

Introduction: Patient-derived xenografts (PDX) can be used to explore tumour pathophysiology and could be useful to better understand therapeutic response in breast cancer. PDX from mammary tumours are usually made from metastatic tumours. Thus, PDX from primary mammary tumours or after neoadjuvant treatment are still rare. This study aims to assess the feasibility to establish xenografts from tumour samples of patients with triple negative or luminal B breast cancer in neoadjuvant, adjuvant or metastatic setting. Methods: XENOBREAST is a single-centre and prospective study. This feasibility pilot trial aims to produce xenografts from tumour samples of patients with triple negative or luminal B breast cancer. Patient enrolment is expected to take 3 years: 85 patients will be enrolled and followed for 28 months. Additional blood samples will be taken as part of the study. Surgical specimens from post-NAC surgery, primary surgery or surgical excision of the metastases will be collected to establish PDX. Histomolecular characteristics of the established PDX will be investigated and compared with the initial histomolecular profile of the collected tumours to ensure that they are well-established. Ethics and dissemination: XENOBREAST belongs to category 2 interventional research on the human person. This study has been approved by the Sud Méditerranée IV – Montpellier ethics committee. It is conducted notably in accordance with the Declaration of Helsinki and General Data Protection Regulation (GDPR). Study data and findings will be published in peer-reviewed medical journals. We also plan to present the study and all data at national congresses and conferences. Registration: ClinicalTrials.gov ID NCT04133077; registered on October 21, 2019.
Economic and disease burden of Japanese encephalitis in Zhejiang Province, 2013–2018
Authors: Deng Xuan , Yan Rui , Li Zi-qiao , Tang Xue-wen , Zhou Yang , He Hanqing 
Published: June 2021

BackgroundJapanese encephalitis (JE) is a mosquito-borne disease and associated with high mortality and disability rate among symptomatic cases. In the absence of local data, this study estimated the economic burden and the disability-adjusted life years (DALYs) due to JE in Zhejiang Province, China during 2013–2018, to increase disease awareness and provide evidence for effective health policy.Methodology/Principle findingsWe merged multiple data sources, including National Notifiable Disease Registry System (NNDRS), patient interviews and medical records from corresponding hospitals for JE cases which occurred during 2013–2018 in Zhejiang Province. Direct costs were extracted from hospitals’ billing systems and patient interviews. Indirect costs and disease burden were calculated based on questionnaire survey from patient interviews and follow-up assessment by general practitioners. Given under-reporting, an expansion factor (EF) was applied to extrapolate the JE burden to the provincial level. The total economic burden of JE during 2013–2018 was estimated at US $12.01 million with an EF = 3. Of this, $8.32 million was due to direct economic cost and $3.69 million to indirect cost. The disease burden of JE was 42.75 DALYs per million population (28.44 YLD, 14.28 YLL) according to the 1990 Global Burden of Disease (GBD 1990) methodology and 80.01 DALYs (53.67YLD, 26.34YLL) according to the GBD 2010 methodology. Sensitivity analysis demonstrated that the overall economic burden varied from US$ 1.73–36.42 million. The greatest variation was due to the prognosis of illness (-85.57%-203.17%), followed by occupation (-34.07%-134.12%) and age (-72.97%-47.69%).Conclusions/SignificanceJE imposes a heavy burden for families and society in Zhejiang Province. This study provides comprehensive empirical estimates of JE burden to increase awareness and strengthen knowledge of the public. These data may support provincial level public health decision making for prevention and control of JE. Ongoing surveillance for acute meningitis and encephalitis syndrome (AEMS) in sentinel hospitals, is needed to further refine estimates of JE burden.
A real-world evaluation of radium-223 in combination with abiraterone or enzalutamide for the treatment of metastatic castration-resistant prostate cancer
Authors: Kim Stephanie I. , Szeto Andy H. , Morgan Katherine P. , Brower Blaine , Dunn Mary W. , Khandani Amir H. , Godley Paul A. , Rose Tracy L. , Basch Ethan M. , Milowsky Matthew I. , Whang Young E. , Crona Daniel J. 
Published: June 2021

Introduction
Radium-223, abiraterone, and enzalutamide have each been shown to significantly improve survival as monotherapy in patients with metastatic castration-resistant prostate cancer. However, effects of combination radium-223 plus abiraterone or enzalutamide on survival and safety remain unclear.

Patients and methods
This single-center retrospective cohort study used electronic health record data of patients with metastatic castration-resistant prostate cancer and bone metastases who were treated with radium-223 between April 1, 2014 and February 19, 2019. Patients who received radium-223 monotherapy were compared to patients who received a combination of radium-223 plus either abiraterone or enzalutamide. The primary endpoint was overall survival. Secondary endpoints included progression-free survival, time to symptomatic skeletal event, symptomatic skeletal event-free survival, and incidence of drug-related adverse events. Time-to-event analyses were estimated by log rank tests using Kaplan-Meier curves. Hazard ratios and 95% confidence intervals were derived from Cox proportional hazards models. Chi-square tests evaluated difference in serious adverse events between the two arms.

Results
A total of 60 patients met inclusion criteria (n = 41 in the monotherapy arm, n = 19 in the combination arm). Differences in median overall survival were not observed (12.7 vs. 12.8 months; HR 1.15, 95% CI 0.59–2.23; P = 0.68), but median progression-free survival was significantly longer in the combination arm (7.6 vs. 4.9 months; HR 1.94, 95% CI 1.11–3.40; P = 0.02). Significant differences were not observed in time to first SSE (P = 0.97), SSE-free survival (P = 0.16), or in the overall incidence of serious adverse events (P = 0.45).

Conclusion
Combination radium-223 plus abiraterone or enzalutamide did not improve overall survival, but prolonged progression-free survival without increasing the incidence of serious adverse events in metastatic castration-resistant prostate cancer patients with bone metastases. However, these results are limited by small numbers and patient selection inherent in retrospective analysis.
Biliary Obstruction After Transjugular Intrahepatic Portosystemic Shunt Placement
Authors: Patel Feenalie , Bick Benjamin 
Published: June 2021

ABSTRACT
A 19-year-old man with noncirrhotic portal hypertension status post transjugular intrahepatic portosystemic shunt, gastric esophageal varices status post coil embolization, and thrombophilia because of Factor V Leiden heterozygosity presented with jaundice and elevated liver enzymes. His cholangiogram during endoscopic retrograde cholangiopancreatography demonstrated biliary tract obstruction at the bifurcation of the right and left hepatic ducts. With the aid of digital single-operator cholangioscopy, the patient was found to have a perforation of the common hepatic duct from the shunt. This case presents a novel use for digital single-operator cholangioscopy in identifying this rare complication and appropriately differentiating biliary compression vs perforation from transjugular intrahepatic portosystemic shunt.
Padovan numbers that are concatenations of two distinct repdigits
Authors: Ddamulira Mahadi 
Published: June 2021

Abstract
Let (Pn
)
n≥0 be the sequence of Padovan numbers defined by P
0 = 0, P
1 = 1 = P
2, and P

n+3 = P

n+1 +Pn
for all n ≥ 0. In this paper, we find all Padovan numbers that are concatenations of two distinct repdigits.
A general inverse matrix series relation and associated polynomials – II
Authors: Sanjhira Reshma 
Published: June 2021

Abstract
We propose a matrix analogue of a general inverse series relation with an objective to introduce the generalized Humbert matrix polynomial, Wilson matrix polynomial, and the Rach matrix polynomial together with their inverse series representations. The matrix polynomials of Kiney, Pincherle, Gegenbauer, Hahn, Meixner-Pollaczek etc. occur as the special cases. It is also shown that the general inverse matrix pair provides the extension to several inverse pairs due to John Riordan [An Introduction to Combinatorial Identities, Wiley, 1968].
Representation of bifinite domains by BF-closure spaces
Authors: Yao Lingjuan , Li Qingguo 
Published: June 2021

Abstract
In this paper, we propose the notion of BF-closure spaces as concrete representation of bifinite domains. We prove that every bifinite domain can be obtained as the set of F-closed sets of some BF-closure space under set inclusion. Furthermore, we obtain that the category of bifinite domains and Scott-continuous functions is equivalent to that of BF-closure spaces and F-morphisms.
Sahabat Alam berkolaborasi dengan nelayan Kondang Merak mengelola wisata alam berbasis konservasi di Desa Sumberbening Kecamatan Bantur Kabupaten Malang
Authors: Septyawati Iis Tri , Sukamto Sukamto , Ruja I Nyoman , Eskasasnanda I Dewa Putu 
Published: June 2021

The research aims to describe (1) the historical pioneering journey of Sahabat Alam at Kondang Merak Beach, (2) the characteristics of Sahabat Alam, (3) an overview of conservation-based nature tourism at Kondang Merak Beach, (4) the role of Sahabat Alam in collaborating with Kondang fishermen. Peacock through conservation-based nature tourism through empowerment. The approach and type of research in this research is descriptive qualitative. The results of this study are that the role of Sahabat Alam in collaborating and implementing the empowerment of Kondang Merak fishermen through conservation-based nature tourism, namely opening new jobs for fishermen as local guides, providing new income allocations through natural tourism package services such as providers of mangrove tree seedlings, providers of reef media. reef and boat rental services. In addition, Sahabat Alam plays a role in providing education and various trainings on conservation and tourism.
Penelitian memiliki tujuan untuk mendeskripsikan (1) perjalanan rintisan sejarah Sahabat Alam di Pantai Kondang Merak, (2) karakteristik Sahabat Alam, (3) gambaran umum wisata alam berbasis konservasi di Pantai Kondang Merak, (4) peran Sahabat Alam dalam berkolaborasi dengan nelayan Kondang Merak melalui wisata alam berbasis konservasi melalui pemberdayaan. Pendekatan dan jenis penelitian dalam penelitian ini yaitu kualitatif deskriptif. Hasil penelitian ini adalah bahwa peran Sahabat Alam dalam berkolaborasi dan pelaksanaan pemberdayaan nelayan Kondang Merak melalui wisata alam berbasis konservasi yaitu membuka lapangan pekerjaan baru bagi nelayan sebagai local guide, menyediakan alokasi pendapatan baru melalui jasa paket wisata alam seperti penyedia bibit pohon mangrove, penyedia media terumbu karang dan jasa sewa perahu. Selain itu Sahabat Alam berperan dalam memberikan edukasi dan berbagai pelatihan tentang konservasi dan wisata.
Akulturasi budaya Tembang Lir-ilir sebagai media dakwah Sunan Kalijaga
Authors: Rumpaka Rori Amelya , Ayundasari Lutfiah 
Published: June 2021

Islam is mostly embraced by Indonesians. The majority of Indonesians adhere to the largest religion in the world. Islam entered the archipelago through peaceful channels in accordance with the religious mission, namely rahmatan li al-'ālamīn. Which is Islam as a religion that embraces or protects all people and other things. Likewise with the culture in Indonesia. Indonesian culture has existed since time immemorial. Various cultures passed on from their ancestors to their successors. Indonesia has a variety of cultural features that need to be preserved and maintained. This is what makes Indonesian society thick with culture. Islam entering Indonesian territory is not easy. Because the majority of people still adhere to and are thick with culture. Therefore, the figures who spread the religion of Islam must know the character of Indonesian society. Using the method of acculturating existing cultures in Indonesia with Islamic religious values is the right way to spread Islam.
Agama Islam dianut sebagian besar oleh masyarakat Indonesia. Mayoritas masyarakat Indonesia menganut agama yang dianut terbesar di dunia ini. Islam masuk ke wilayah Nusantara melalui jalur damai sesuai dengan misi agama yakni rahmatan li al-‘ālamīn. Yang mana Islam sebagai agama yang merangkul atau mengayomi semua umat dan hal lainnya. Begitu pula dengan kebudayaan yang ada di Indonesia. Kebudayaan Indonesia sudah ada sejak dahulu kala. Beragam kebudayaan diwariskan para leluhur kepada penerusnya. Indonesia memiliki beragam corak kebudayaan yang perlu dilestarikan dan dijaga keberadaannya. Hal tersebut yang menjadikan masyarakat Indonesia kental akan budaya. Agama Islam masuk ke wilayah Indonesia tidak mudah. Dikarenakan mayoritas masyarakat masih menganut dan kental akan budaya. Maka dari itu, para tokoh penyebar agama Islam harus mengetahui karakter masyarakat Indonesia. Menggunakan cara mengakulturasi budaya yang ada di Indonesia dengan nilai-nilai agama Islam merupakan cara yang tepat untuk penyebaran agama Islam.
SARS-CoV-2-related Multisystem Inflammatory Syndrome in Children
Authors: Al Maskari Nawal , Al Mukhaini Kholoud , Al Abrawi Safiya , Al Reesi Mohammed , Al Abulsalam Juhaina , Elsidig Nagi 
Published: June 2021

On 27 April 2020, the National Health Service England issued an emergency alert for a new condition owing to the observation of an increasing number of cases of a COVID-19-related hyperinflammatory syndrome termed multisystem inflammatory syndrome in children (MIS-C). Some of the presenting symptoms appeared similar to the Kawasaki disease and toxic shock syndrome. We report the cases of six children fitting the criteria of MIS-C, admitted to Royal Hospital and Sohar Hospital, Oman, between the months of June and July in 2020. Four of these patients required admission at the paediatric intensive care unit for inotropic support while two were admitted to the paediatric ward on suspicion of appendicitis. MIS-C has been reported in a small number of individuals below the age of 21 years with a median age of 9–10 years. Five of the current patients were aged less than the median age reported in the existing literature. All of the patients showed complete recovery with supportive management, intravenous immunoglobulin and steroids, with one patient requiring interleukin-6 inhibitor (tocilizumab).
Keywords: COVID-19; SARS-CoV-2; Kawasaki Disease; Multisystem Inflammatory Syndrome in Children; Toxic Shock Syndrome; Case Report; Oman.
Outcomes of Infants Undergoing Modified Blalock-Taussig Shunt Procedures in Oman
Authors: Shaikh Samiuddin , Al-Mukhaini Khaloud S , Al-Rawahi Abdul Hakeem , Al-Dafie Omer 
Published: June 2021

Objectives: A modified Blalock-Taussig (mBT) shunt procedure is a common palliative surgery used to treat infants and children with cyanotic congenital heart disease (CCHD). This study aimed to report the outcomes of infants and children undergoing mBT shunt procedures in Oman. In addition, risk factors associated with early mortality, inter-stage mortality and reintervention were assessed. Methods: This retrospective cohort study was conducted from January 2016 to December 2018 at the National Heart Centre, Muscat, Oman. All paediatric patients with CCHD undergoing mBT shunt procedures as a primary palliative procedure during this period were included. Data were retrieved from electronic hospital records. Kaplan-Meier survival curves were used to describe overall survival. Results: A total of 50 infants and children were included in the study. The in-hospital mortality and inter-stage mortality rates were 10% and 6.7%, respectively. Preoperative mechanical ventilation (odds ratio [OR]: 3.00, 95% confidence interval [CI]: 1.98–4.76; P = 0.007) and cardiopulmonary bypass (OR: 4.09, 95% CI: 2.44–6.85; P = 0.002) were significant risk factors for early mortality. In-hospital and interval surgical reintervention rates were 12% and 13.3%, respectively. Following the primary shunt procedure, the median time to second-stage surgery was 15.5 months (range: 5.0–34.0 months). Conclusion: The findings of this study support those reported in international research regarding the risks associated with mBT shunt surgeries. In particular, preoperative mechanical ventilation and cardiopulmonary bypass were significant risk factors for early mortality.
Keywords: Pediatrics; Heart Diseases, congenital; Cardiovascular Surgical Procedures; Modified Blalock-Taussig Procedure; Patient Outcome Assessment; Hospital Mortality; Risk Factors; Oman.
ANALISA ORGANOLEPTIK DAN MIKROBIOLOGI AMDK DAN AMIU YANG DIJUAL SEKITAR KAMPUS UMKU
Authors: Rusidah Yunita , Farikhah Lailatul 
Published: June 2021

This study is intended to find the quality of bottled drinking water (AMDK) and drinking water (AMIU) sold around University of Muhammadiyah Kudus, in terms of organoleptic and microbiological parameters in drinking water according to SNI 01-3554-2006 and PMK No. 492 of 2010. The test is carried out using 10 sample of drinking water. They are 7 sample of AMDK (Ades, Airmu, Aqua, Cleo, Crystalin, Le mineral and Vit) and 3 sample of AMIU (Pasuruhan, Prambatan and Purwosari depots). The research consists of organoleptic and mikrobiologi (TPC, presence of E. coli and total coliform). The results of research shows that the organoleptik of all samples is in normal condition. Whereas, microbiologically, the TPC results before dilution were only Cleo and Ades which were suitable for consumption because they were absent from bacterial contamination. While the TPC results after dilution, testing the difference between E. Coli and Total coliform resulted in 7 samples of bottled drinking water which were safe and feasible as drinking water according to SNI 01-3553-2006 and 3 samples AMIU does not fulfil PMK No. 492/2010, as drinking water requirements.
COVID-19 and aspiration pneumonia: similar pulmonary findings with different diagnoses. A pitfall in [18F]FDG PET/CT.
Authors: Liberini Virginia , Grimaldi Serena , Huellner Martin W. , Giunta Francesca , Bachi Costanza , Dall’Armellina Sara , Onesti Federica , Ceci Francesco , Boccomini Carola , Icardi Massimiliano , Deandreis Désirée 
Published: June 2021

Abstract
Since December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a worldwide pandemic. Especially in the centers most affected by the pandemic, symptoms (such as fever, cough, myalgia, or fatigue) and/or radiological signs (such as ground-glass opacity) typically related to COVID-19 often diverted clinicians’ attention from other diseases. Despite the urgency to recognize and cure SARS-CoV-2 infection, a plethora of differential diagnoses must be considered, and other diseases must be equally and promptly treated, as described in this case report.
Mercury uptake by Paspalum distichum L. in relation to the mercury distribution pattern in rhizosphere soil
Authors: Xu Su , Gong Ping , Ding Wen , Wu Shengchun , Yu Xinwei , Liang Peng 
Published: June 2021

Abstract
Paspalum distichum L. was tested to evaluate their phytoremediation capacity for Hg contaminated soil through analyzing the dissipation of Hg in soil through a greenhouse study by using self-made rhizos box. Original soil samples were collected at Hg mining site with serious Hg contamination and a control site, respectively. Planting of P. distichum. L last for 60 days. Soil and plant samples were collected from four periods (0 d, 20 d, 40 d and 60 d) and soil samples were collected from five different rhizosphere distance in horizontal direction (0–2 cm, 2-4cm, 4-6cm, 6-8cm,8-10cm). The results showed that the presence of P. distichum. L significantly accelerated the Hg dissipation in soil compared with control. Hg concentration in the rhizospheric soil was affected by the plant growth period and the distance to the plant roots. The closer of soil to the root of P. distichum. L, the lower mercury concentration in soil. During the 60-day growing period, the concentrations of total Hg (THg) and methylmercury (MeHg) reduced by 45% and 64%, respectively, in the rhizosphere (0-2cm) of Hg contaminated soil. However, MeHg concentration was increased near the roots (0–4 cm) during the initial growing period (0–20 d), which may be attributed to the influence of root exudates. Root is the major part for Hg accumulation in P. distichum. L. The low ratio between Hg concentrations in underground and aboveground tissues indicated that it seemed difficult for Hg translocation from root to shoot. The highest THg (9.71 ± 3.09 µg·g− 1) and MeHg (26.97 ± 0.98 ng·g− 1) value in root of P. distichum. L were observed at the 20th day when P. distichum. L grown in Hg contaminated soil. The results of chemical fractions analyses showed that elemental Hg and residual Hg were the two major speciations followed by organic bound Hg in the Hg contaminated soil, which indicated the high bioavailability and ecological potential risk of Hg in Hg contaminated soil.
A Multiple-Bands Metamaterial Absorber Based in X, Ku and K-Band
Authors: Zafar Muhammad Fahim , Masud Usman 
Published: June 2021

Abstract
Developing a highly efficient and multiple-bands metamaterial absorber is a hot issue in recent era. In this paper, A multiple-bands metamaterial absorber has been presented which is based in X, Ku and K-band. Firstly, we have designed two single layer basic unit cell of X-shape and cross-shape, then they are arranged in the multi-layers structure form for the purpose of obtaining multiple- bands and wide band absorption. The proposed absorber is able to work in multiple bands because it has six peaks in the frequency range of 8–24 GHz with having near perfect absorption. Moreover, the sixth peak has a wideband absorption which is 2.93 GHz. Furthermore, the proposed absorber is also tested for polarization insensitivity and also for oblique incidence. Absorption was found polarization insensitive with almost perfect absorption.