bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating black hole masses in obscured AGN using X-rays
Authors: Gliozzi Mario , Williams James K , Michel Dina A 
Published: January 2021

ABSTRACT
Determining the black hole masses in active galactic nuclei (AGN) is of crucial importance to constrain the basic characteristics of their central engines and shed light on their growth and co-evolution with their host galaxies. While the black hole mass (MBH) can be robustly measured with dynamical methods in bright type 1 AGN, where the variable primary emission and the broad-line region are directly observed, a direct measurement is considerably more challenging if not impossible for the vast majority of heavily obscured type 2 AGN. In this work, we tested the validity of an X-ray-based scaling method to constrain the MBH in heavily absorbed AGN. To this end, we utilized a sample of type 2 AGN with good-quality hard X-ray data obtained by the Nuclear Spectroscopic Telescope Array satellite and with MBH dynamically constrained from megamaser measurements. Our results indicate that, when the X-ray broad-band spectra are fitted with physically motivated self-consistent models that properly account for absorption, scattering, and emission-line contributions from the putative torus and constrain the primary X-ray emission, then the X-ray scaling method yields MBH values that are consistent with those determined from megamaser measurements within their respective uncertainties. With this method, we can therefore systematically determine the MBH in any type 2 AGN, provided that they possess good-quality X-ray data and accrete at a moderate to high rate.
Redshift evolution of the H2/H i mass ratio in galaxies
Authors: Morselli Laura , Renzini A , Enia A , Rodighiero G 
Published: January 2021

ABSTRACT
In this paper, we present an attempt to estimate the redshift evolution of the molecular to neutral gas mass ratio within galaxies (at fixed stellar mass). For a sample of five nearby grand design spirals located on the main-sequence (MS) of star-forming galaxies, we exploit maps at 500 pc resolution of stellar mass and star formation rate (M⋆ and SFR). For the same cells, we also have estimates of the neutral (MH i) and molecular ($M_{\rm H_2}$) gas masses. To compute the redshift evolution, we exploit two relations: (i) one between the molecular-to-neutral mass ratio and the total gas mass (Mgas), whose scatter shows a strong dependence with the distance from the spatially resolved MS, and (ii) the one between $\log (M_{\rm {H_2}}/M_{\star })$ and log (MH i/M⋆). For both methods, we and that $M_{\rm H_2}$/MH i within the optical radius slightly decreases with redshift, contrary to common expectations of galaxies becoming progressively more dominated by molecular hydrogen at high redshifts. We discuss possible implications of this trend on our understanding of the internal working of high-redshift galaxies.
Nuclear factor-kappa B signaling in endometriotic stromal cells is not inhibited by progesterone owing to an aberrant endoplasmic reticulum stress response: a possible role for an altered inflammatory process in endometriosis
Authors: Choi JongYeob , Jo MinWha , Lee EunYoung , Lee Dong-Yun , Choi DooSeok 
Published: January 2021

Abstract
Endoplasmic reticulum (ER) stress serves as a key modulator of the inflammatory response by controlling nuclear factor-kappaB (NF-κB) signaling. Previous studies from our laboratory have reported an abnormal induction of ER stress linked to progesterone resistance in human endometriotic cells. Therefore, an aberrant ER stress response to progesterone might contribute to the altered inflammatory response observed in endometriotic tissues. To evaluate this hypothesis, we investigated whether ER stress is involved in regulation of NF-κB in endometrial stromal cells and whether induction of aberrant ER stress in endometriotic stromal cells affects pro-inflammatory cytokine production. We found that tunicamycin-induced ER stress inhibited NF-κB activation and pro-inflammatory cytokine (IL-6 and COX2) production in TNF-α- or IL-1β-treated normal endometrial stromal cells (NECSs). Tunicamycin increased the expression of A20 and C/EBPβ, which are negative regulators of NF-κB, and this increase inhibited NF-κB activity in NESCs incubated with TNF-α or IL-1β. Similarly, progesterone increased A20 and C/EBPβ expression through upregulation of ER stress in NESCs, resulting in inhibition of NF-κB activity and IL-6 and COX2 production. However, progesterone had no significant effects on induction of ER stress, A20 or C/EBPβ expression, NF-κB activity or IL-6 or COX2 production in ovarian endometriotic cyst stromal cells (ECSCs). In contrast, upregulation of ER stress by tunicamycin significantly reduced IL-6 and COX2 production by inhibiting NF-κB activity in ECSCs. In conclusion, our results suggest that NF-κB activity in endometriotic stromal cells was not inhibited because of an aberrant ER stress response to progesterone, resulting in an increase in pro-inflammatory cytokine production.
Is there more than one species in the genusSpirula(Cephalopoda: Decabrachia): evidence for an Atlantic–Pacific divide
Authors: Hoffmann René , Weinkauf Manuel F G , Fuchs Dirk , Lukeneder Alexander 
Published: January 2021

ABSTRACTSpirula spirula (Coleoidea: Decabrachia) is a unique deep-sea squid with an uncertain taxonomic status. Here, we apply geometric morphometric analyses to precisely describe changes in conch morphology during the course of ontogeny of 21 specimens collected from 12 localities worldwide. These data were used to explore whether the genus is monospecific or comprises several species. Different 2D and 3D conch parameters are presented based on micro-computed tomography data, combining noninvasive imaging techniques with a range of morphometric analyses. Our data imply that Atlantic and Indo-Pacific specimens form two distinct morphological clusters, potentially representing two pseudocryptic species or two populations undergoing divergence (i.e. in the process of speciation). Given the evolutionary trend from straight to more coiled forms, we suggest that S. spirula represents a neotenous form that migrated from the Indo-Pacific towards the Atlantic via the Agulhas leakage, which has been active since the closure of the Strait of Panama (10–3 Ma).
Differences in Levels of Biomarkers of Potential Harm Among Users of a Heat-Not-Burn Tobacco Product, Cigarette Smokers, and Never-Smokers in Japan: A Post-Marketing Observational Study
Authors: Sakaguchi Chikako , Nagata Yasufumi , Kikuchi Akira , Takeshige Yuki , Minami Naoki 
Published: January 2021

Abstract

Introduction
Cigarette smoking is associated with the risk of certain diseases, but non-combustible products may lower these risks. The potential long-term health effects of the next-generation non-combustible products (heat-not-burn tobacco products (HNBP) or electronic vapor products) have not been thoroughly studied. The present study aimed to investigate the impact of biomarkers of potential harm (BoPH) of one of HNBP (a novel vapor product: NTV (novel tobacco vapor)), under the conditions of actual use.

Aims and Methods
This study was an observational, cross-sectional, three-group, multi-center study. Exclusive NTV users (NTV, n = 259), conventional cigarette smokers (CC, n = 100) and never-smokers (NS, n = 100) were enrolled. Biomarkers of tobacco smoke exposure (cotinine and total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)) and BoPH including parameters of physical pulmonary functions relevant to smoking-related diseases were examined, and subjects answered a questionnaire on cough-related symptoms (J-LCQ) and health-related quality of life (SF-36v2®).

Results
Levels of cotinine, total NNAL and BoPH (high-density lipoprotein (HDL)-cholesterol, triglyceride, sICAM-1, WBC count, 11-DHTXB2, 2,3-d-TXB2, 8-epi-PGF2α, forced expiratory volume in 1 second (FEV1), % predicted value of FEV1 (%FEV1) and maximum midexpiratory flow (FEF25-75)) were significantly different in the NTV group as compared to levels in CC group (p &lt; .05). Significantly higher levels of cotinine, total NNAL, and 2,3-d-TXB2, and lower levels of FEV1 and %FEV1, were observed among NTV users compared to the NS group.

Conclusion
In a post-marketing study under actual use conditions, BoPH associated with smoking-related disease examined in exclusive NTV users were found to be favorably different from those of CC smokers, a finding attributable to a reduction in exposure to harmful substances of tobacco smoke.

Implications
Cigarette smoking is associated with an increased risk of pulmonary diseases like COPD, cardiovascular diseases, and certain cancers. There is a growing body of evidence that HNBP reduces the exposure associated with smoking and that there is a favorable change in BoPH. However, long-term effects regarding the relative health risks to HNBP users compared to CC smokers have not been examined. This study provides post-marketing data under actual use conditions of the effects on biomarkers of potential harm in NTV, one of HNBP, exclusive users compared to CC smokers and never-smokers. The evidence suggests that exclusive NTV users have favorable levels of BoPH compared to CC smokers, and that is result from a sustained reduction in exposure to harmful substances of tobacco smoke.
Covid-19 shelter-at-home and work, lifestyle and well-being in desk workers
Authors: Barone Gibbs B , Kline C E , Huber K A , Paley J L , Perera S 
Published: January 2021

Abstract

Background
Emerging cross-sectional reports find that the COVID-19 pandemic and related social restrictions negatively affect lifestyle behaviours and mental health in general populations.

Aims
To study the longitudinal impact of COVID-19 on work practices, lifestyle and well-being among desk workers during shelter-at-home restrictions.

Methods
We added follow-up after completion of a clinical trial among desk workers to longitudinally measure sedentary behaviour, physical activity, sleep, diet, mood, quality of life and work-related health using validated questionnaires and surveys. We compared outcomes assessed before and during COVID-19 shelter-at-home restrictions. We assessed whether changes in outcomes differed by remote working status (always, changed to or never remote) using analysis of covariance (ANCOVA).

Results
Participants (N = 112; 69% female; mean (SD) age = 45.4 (12.3) years; follow-up = 13.5 (6.8) months) had substantial changes to work practices, including 72% changing to remote work. Deleterious changes from before to during shelter-at-home included: 1.3 (3.5)-h increase in non-workday sedentary behaviour; 0.7 (2.8)-point worsening of sleep quality; 8.5 (21.2)-point increase in mood disturbance; reductions in five of eight quality of life subscales; 0.5 (1.1)-point decrease in work-related health (P &lt; 0.05). Other outcomes, including diet, physical activity and workday sedentary behaviour, remained stable (P ≥ 0.05). Workers who were remote before and during the pandemic had greater increases in non-workday sedentary behaviour and stress, with greater declines in physical functioning. Wake time was delayed overall by 41 (61) min, and more so in workers who changed to remote.

Conclusions
Employers should consider supporting healthy lifestyle and well-being among desk workers during pandemic-related social restrictions, regardless of remote working status.
An evaluation of influenza vaccine uptake in UK medical students
Authors: Gray G , Cooper J 
Published: January 2021

Abstract

Background
The annual influenza vaccination is recommended for all front-line healthcare workers in the UK and is a crucial way of reducing mortality for vulnerable patient groups. However, to date the UK government has never explicitly monitored influenza vaccine uptake in medical students. This is important to ascertain, as students regularly move between clinical areas and are both a perfect vector for the spread of influenza and at an increased risk of contracting influenza themselves.

Aims
This service evaluation was designed to evaluate the effectiveness of an influenza vaccination programme in one UK medical school and make recommendations to increase vaccination rates in the future.

Methods
This service evaluation collected data about medical student uptake of influenza vaccination in one UK medical school. Two hundred and fifty-one students at different course stages completed questionnaires, answering questions on vaccination status and Likert-scale ‘belief’ questions to assess the subjective reasons behind vaccine refusal.

Results
There was a substantial difference between year group cohorts (~20%), with significantly higher vaccination rates in the preclinical year group. Two significant negative predictors of vaccination were found (P &lt; 0.001), related to scepticism over the effectiveness of the vaccine and lack of convenient access to the vaccination. Results indicated that integrating information about the influenza vaccine into the curriculum would reduce lack of knowledge over the efficacy of the vaccine. The centralization of vaccination programmes at mandatory university-based learning events would mitigate against the problem of diversity of vaccination locations and lack of central accountability.

Conclusions
The results of this service evaluation provide significant predictors of vaccination status for medical students and potential occupational health interventions to improve vaccine uptake in this group.
Bone Flap Resorption in Pediatric Patients Following Autologous Cranioplasty
Authors: Hersh David S , Anderson Hanna J , Woodworth Graeme F , Martin Jonathan E , Khan Yusuf M 
Published: January 2021

Abstract
Following a decompressive craniectomy, the autologous bone flap is generally considered the reconstructive material of choice in pediatric patients. Replacement of the original bone flap takes advantage of its natural biocompatibility and the associated low risk of rejection, as well as the potential to reintegrate with the adjacent bone and subsequently grow with the patient. However, despite these advantages and unlike adult patients, the replaced calvarial bone is more likely to undergo delayed bone resorption in pediatric patients, ultimately requiring revision surgery. In this review, we describe the materials that are currently available for pediatric cranioplasty, the advantages and disadvantages of autologous calvarial replacement, the incidence and classification of bone resorption, and the clinical risk factors for bone flap resorption that have been identified to date.
A general process model for unanticipated state recognition of a telescope drive system
Authors: Li Yun , Yang Shihai , Wu Jiajia , Gu Bozhong 
Published: January 2021

Abstract
This paper presents a three-layer general process model for unanticipated state recognition in a telescope drive system, consisting of an anticipated fault diagnosis layer, an unanticipated normal state isolation layer, and an unanticipated fault state recognition layer. It is proposed for the first time to subdivide the unanticipated state into an unanticipated normal state and an unanticipated fault state in this paper, and to study their theories separately. Unanticipated normal state isolation rules based on angle deviation and amplitude deviation are established, as are unanticipated fault state recognition rules based on angle deviation and deviation contribution factor. Finally, normal operation data of the Antarctic Survey Telescope (AST3-3) combined with fault implantation was used to verify the validity of the model. The results show that the method can effectively carry out isolation of the unanticipated normal state and identification of the unanticipated fault state.
SlERF52 regulates SlTIP1;1 expression to accelerate tomato pedicel abscission
Authors: Wang Rong , Li Ruizhen , Cheng Lina , Wang Xiaoyang , Fu Xin , Dong Xiufen , Qi Mingfang , Jiang Caizhong , Xu Tao , Li Tianlai 
Published: January 2021

Abstract
Abscission of plant organs is induced by developmental signals and diverse environmental stimuli and involves multiple regulatory networks, including biotic or abiotic stress-impaired auxin flux in the abscission zone (AZ). Depletion of auxin activates AZ ethylene (ETH) production and triggers acceleration of abscission, a process that requires hydrogen peroxide (H2O2). However, the interaction between these networks and the underlying mechanisms that control abscission are poorly understood. Here, we found that expression of tonoplast intrinsic proteins, which belong to the aquaporin (AQP) family in the AZ was important for tomato (Solanum lycopersicum) pedicel abscission. Liquid chromatography–tandem mass spectrometry and in situ hybridization revealed that SlTIP1;1 was most abundant and specifically present in the tomato pedicel AZ. SlTIP1;1 localized in the plasma membrane and tonoplast. Knockout of SlTIP1;1 resulted in delayed abscission, whereas overexpression of SlTIP1;1 accelerated abscission. Further analysis indicated that SlTIP1;1 mediated abscission via gating of cytoplasmic H2O2 concentrations and osmotic water permeability (Pf). Elevated cytoplasmic levels of H2O2 caused a suppressed auxin signal in the early abscission stage and enhanced ETH production during abscission. Furthermore, we found that increasing Pf was required to enhance the turgor pressure to supply the break force for AZ cell separation. Moreover, we observed that SlERF52 bound directly to the SlTIP1;1 promoter to regulate its expression, demonstrating a positive loop in which cytoplasmic H2O2 activates ETH production, which activates SlERF52. This, in turn, induces SlTIP1;1, which leads to elevated cytoplasmic H2O2 and water influx.
In loving memory of ‘us’: facing grief during the time of COVID-19 through redirecting perception of life’s realities
Authors: Cordero Dalmacito A 
Published: January 2021

Abstract
Recent correspondence highlighted the complicated process of grief in the time of COVID-19 where some family members and the dying person too are undergoing distress. New rituals can lighten the process of coping with grief or death, one may find it difficult to hurdle such situation and move on without first redirecting one’s perception on the different realities of life. There are things that we can control but at the same time, things that are beyond our reach. With these realities, acceptance plays a key role to handle the situation. Acceptance is a person’s assent to life’s realities. Creativity in accepting grief or death is finding ways to lighten the heavy emotion of the ‘ones left and the one leaving’ through a preservation of memory. This is done through safeguarding and reliving the memories of the dead with various programs and advocacies.
Does the Phenomenology of Auditory Hallucinations Differ Across Patients Having Severe Mental Illness With and Without Hearing Impairment?
Authors: Sadh Kamaldeep , Mehta Urvakhsh M , Muralidharan Kesavan , Shivashankar N , Jain Sanjeev 
Published: January 2021

Abstract
We compared the experience of auditory hallucinations, in persons who have normal (HN; N = 20), or impaired hearing (HI; N = 20), while experiencing psychoses. We assessed this experience across 42 domains and observed that irrespective of the hearing status, patients most often heard voices mainly in the language that they had learnt first (χ2 = 5.584; P = .018). However, a few experienced hallucinations in languages they “did not know” (3/20; 15%). The voices were most often attributed to both males and females (35/40; 87.5%). Those with hearing impairment heard voices closer to their ears, a hubbub of voices of crowds talking to them, and “as if” stuck or repetitive; often in the hearing-impaired ear. The hearing-impaired subjects also reported hearing nonverbal auditory hallucinations more frequently (χ2 = 17.625; P = .001), and the voices lacked emotional salience (χ2 = 4.055; P = .044). In contrast, the hallucinations were experienced in elaborate detail by the HN (20/20), while those with HI often heard only simple sentences (14/20, P = 0.05). The intensity of the hallucinatory voices remained the same on closing the affected ear or both of the ears in the HI group as compared to the HN group. Interestingly, the use of hearing aids attenuated the intensity of the hallucinations (6/7; 85%) in those with HI.
Adaptive Tree Proposals for Bayesian Phylogenetic Inference
Authors: Meyer X 
Published: January 2021

AbstractBayesian inference of phylogeny with Markov chain Monte Carlo plays a key role in the study of evolution. Yet, this method still suffers from a practical challenge identified more than two decades ago: designing tree topology proposals that efficiently sample tree spaces. In this article, I introduce the concept of adaptive tree proposals for unrooted topologies, that is, tree proposals adapting to the posterior distribution as it is estimated. I use this concept to elaborate two adaptive variants of existing proposals and an adaptive proposal based on a novel design philosophy in which the structure of the proposal is informed by the posterior distribution of trees. I investigate the performance of these proposals by first presenting a metric that captures the performance of each proposal within a mixture of proposals. Using this metric, I compare the performance of the adaptive proposals to the performance of standard and parsimony-guided proposals on 11 empirical data sets. Using adaptive proposals led to consistent performance gains and resulted in up to 18-fold increases in mixing efficiency and 6-fold increases in convergence rate without increasing the computational cost of these analyses. [Bayesian phylogenetic inference; Markov chain Monte Carlo; posterior probability distribution; tree proposals.]
In UteroMaternal Benzene Exposure Predisposes to the Metabolic Imbalance in the Offspring
Authors: Koshko Lisa , Debarba Lucas K , Sacla Mikaela , de Lima Juliana B M , Didyuk Olesya , Fakhoury Patrick , Sadagurski Marianna 
Published: January 2021

AbstractEnvironmental chemicals play a significant role in the development of metabolic disorders, especially when exposure occurs early in life. We have recently demonstrated that benzene exposure, at concentrations relevant to cigarette smoke, induces a severe metabolic imbalance in a sex-specific manner affecting male but not female mice. However, the roles of benzene in the development of aberrant metabolic outcomes following gestational exposure, remain largely unexplored. In this study, we exposed pregnant C57BL/6JB dams to benzene at 50 ppm or filtered air for 6 h/day from gestational day 0.5 (GD0.5) through GD21 and studied male and female offspring metabolic phenotypes in their adult life. While no changes in body weight or body composition were observed between groups, 4-month-old male and female offspring exhibited reduced parameters of energy homeostasis (VO2, VCO2, and heat production). However, only male offspring from benzene-exposed dams were glucose intolerant and insulin resistant at this age. By 6 months of age, both male and female offspring exhibited marked glucose intolerance however, only male offspring developed severe insulin resistance. This effect was accompanied by elevated insulin secretion and increased beta-cell mass only in male offspring. In support, Homeostatic Model Assessment for Insulin Resistance, the index of insulin resistance was elevated only in male but not in female offspring. Regardless, both male and female offspring exhibited a considerable increase in hepatic gene expression associated with inflammation and endoplasmic reticulum stress. Thus, gestational benzene exposure can predispose offspring to increased susceptibility to the metabolic imbalance in adulthood with differential sensitivity between sexes.