bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on hysteretic behavior of concrete CFRP specimen
Authors: Qing-li Wang , Yi-Huan Guo , Peng Kuan , Yong-bo Shao 
Published: December 2021

Abstract
In order to study the hysteretic behavior of concrete CFRP specimen under different influence factors, 12 specimens were designed. By consulting related literature, the research progress and main results of concrete-wrapped CFRP at home and abroad in recent years are summarized, and the accurate solution calculated by the multi-scale method and the error of the experimental value are verified by MATLAB. The non-linear vibration generated by the hysteretic performance under the action of wind excitation is introduced, which provides a certain reference for the later research.
Setting Up the Stillbirth Registration System and Investigating the Related Causes in Iran in Selected Hospitals: Observational Cohort Study
Authors: Moradi-Lakeh Maziar , Heidarzadeh Mohammad , Habibelahi Abbas , Khalili Narjes , Motamedi Mahnaz , Larijani Samaneh Saghafian , Kashanian Maryam , Taraghi Fatemeh 
Published: December 2021

Abstract
Background
One of the major causes of perinatal mortality is stillbirth. In many cases, the cause of stillbirth is difficult to identify, and the cause of many cases remain unexplained. Because of the lack of registration stillbirth system in our country we developed protocol and instructions for stillbirth and setting up a stillbirth registration system in selected hospitals around country.
Methods
Iranian Maternal and Neonatal Network (IMaN) registers information about almost all births (live & dead) around the country, but this network does not collect data about stillbirth causes. In this study, we developed the stillbirth evaluation protocol with experts' cooperation, and we designed forms for the stillbirth registration system electronically. Then we trained related individuals in 14 selected hospital from 12 provinces (14 cities) of Iran. After a year, we extracted, analyzed, and, based on the Relevant Condition of Death Classification (ReCoDe), interpreted the collected data.
Results
A total of 105,562 births and 762 stillbirths registered. In 742 registered stillbirth cases in 14 selected hospitals, the relevant causes were identified in 65.4% of cases, while 34.6% of cases remained unclassified. The most frequent relevant conditions were fetal (33.2%), maternal (9.1%), amniotic fluid (8.8%), placenta (7.7%), and umbilical cord (6.2%).
Conclusions
Our registration decreased the percentage of stillbirth with an unexplained cause from about 70–34.6%.
Platelet-To-Lymphocyte Ratio Can Be Used As Marker To Predict Activity And Severity In Moderate And High Disease Activity of Rheumatoid Arthritis: A Retrospective Study
Authors: Chen Bilin , Zhu Qing , Li Shu , Ge Yan , Wu Peijun , Tian Jing , Xie Xi , Li Fen 
Published: December 2021

Abstract
Objective: This study aimed to study and evaluate the value of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) as markers to predict the disease activity and severity in patients with rheumatoid arthritis (RA).Methods: A total of 139 inpatients with RA were divided into two groups: moderate activity group (3.2<DAS28-CRP score<5.1) and high activity group (≥5.1). The correlation of routine hematological indices with DAS28 and joint ultrasound score (gray-scale ultrasound score, GS-US; power Doppler ultrasound score, PD-US; total ultrasound score, T-US) were analyzed by Pearson's correlation and logistic regression analyses. Receiver operating characteristics (ROC) analysis was performed to compare the efficacy of blood indices, ESR, or CRP in reflecting the disease activity and severity of RA.Results: The values of PLR, NLR, PD-US, and T-US were significantly different between moderate and high disease activity groups (p<0.001), and PLR was significantly correlated with PD-US and DAS28. Logistic regression analyses showed that PLR was an independent risk factor for disease activity by DAS 28 and joint damage severity by PD-US and T-US. ROC analysis showed that the efficacy of using PLR alone to evaluate the disease activity and joint severity of RA was similar to that of using combined CRP and ESR. The best cut-off value of PLR for predicting high disease activity and high joint severity was determined as 236.6.Conclusions: PLR can be used as a marker to predict activity and severity in patients with moderate and high RA disease activity.
Optimal Region Gradated Fusion Based Automatic Image Stitching for Industrial Systems
Authors: Huang Yanlin , Zheng Meilian , Song Ziwei , Mei Songzhu , Wang Zebin , Jia Gangyong 
Published: December 2021

Abstract
In the process of equipment production in large manufacturing, the continuity of production is becoming more significant. Timely detection of equipment operation faults can ensure production continuity and greatly reduce loss. In this study, the purpose is to use multi-equipment and image stitching algorithm to obtain the complete image of a large-scale production line. An improved image stitching method based on image fusion is proposed in this paper, which mainly solves the technical problems of stitching seams, unnatural effects, and distortion after image transformation in the existing stitching technique. In the image stitching algorithm, the improved fusion algorithm based on the optimal seam and gradated in and out fusion algorithm is used to realize image fusion, including the use of dynamic programming to find the optimal seam and limit the range of fusion based on the optimal seam found. Finally, the gradated in and out fusion algorithm is used to perform fusion calculation within the limited fusion range to complete image stitching. In the end, through the comparison of different dimensional image fusion indicators with the effect of the existing fusion algorithm, the experimental results show that the method in this paper solves the problem of unnatural image stitching effect, enhances the image stitching result, and has the great fusion effect. Therefore, the panorama processed by the image stitching algorithm proposed in this paper can be efficiently processed through the industrial detection module.
Molecular Detection of SARS-Cov-2 in Exhaled Breath Using a Portable Sampler
Authors: Stakenborg Tim , Raymenants Joren , Taher Ahmed , Marchal Elisabeth , Verbruggen Bert , Roth Sophie , Jones Ben , Yurt Abdul , Duthoo Wout , Bombeke Klaas , Fauvart Maarten , Verplanken Julien , Wiederkehr Rodrigo , Humbert Aurelie , Dang Chi , Vlassaks Evi , Uribe Alejandra Jauregui , Luo Zhenxiang , Liu Chengxun , Zinoviev Kirill , Labie Riet , Frederiks Aduén Darriba , Saldien Jelle , Covens Kris , Berden Pieter , Schreurs Bert , Duppen Joost Van , Hanifa Rabea , Beuscart Megane , Pham Van , Emmen Erik , Dewagtere Annelien , Lin Ziduo , Peca Marco , Jerrari Youssef El , Nawghane Chinmay , Arnett Chad , Lambrechts Andy , Deshpande Paru , Lagrou Katrien , De Munter Paul , André Emmanuel , Wijngaert Nik Van den , Peumans Peter 
Published: December 2021

Abstract
The SARS-CoV-2 pandemic has highlighted the need for improved technologies to help control the spread of contagious pathogens. While rapid point-of-need testing plays a key role in strategies to rapidly identify and isolate infectious patients, a cornerstone for any disease-control strategy, current test approaches have significant shortcomings related to assay limitations and sample type. Direct quantification of viral shedding in exhaled particles may offer a better rapid testing approach, since SARS-CoV-2 is believed to spread mainly by aerosols. It potentially measures contagiousness directly, the sample is easy to obtain, its production can be standardized between patients, and the limited sample volume lends itself to a fast and sensitive analysis. In view of these benefits, we developed and tested an approach where exhaled particles are efficiently sampled using inertial impaction in a micromachined silicon chip, followed by an in-situ RT-qPCR molecular assay to detect SARS-CoV-2 shedding. We demonstrate that sampling subjects using a one-minute breathing protocol, yields sufficient viral RNA to detect infections with a sensitivity comparable to standard sampling methods. A longitudinal study revealed clear differences in the temporal dynamics of viral load for nasopharyngeal swab, saliva, breath, and antigen tests. Overall, after an infection, the breath-based test is the first to consistently report a negative result, putatively signaling the end of contagiousness and further emphasizing the potential of this tool to help manage the spread of airborne respiratory infections.
Scutellaria Barbata D.Don (SBD) Extracts Suppressed Tumor Growth, Metastasis and Angiogenesis in Prostate Cancer Via PI3K/Akt Pathway
Authors: Sheng Dongya , Zhao Bei , Zhu Wenjing , Wang Tiantian , peng yu 
Published: December 2021

Abstract
Background: Scutellaria barbata D.Don (SBD) is derived from the dried whole plant of Labiate that has been widely used to treat patients with multiple cancer. It was previously reported that the ethanol extract of SBD is able to promote apoptosis, and inhibit cell proliferation and angiogenesis in cancer.Materials and methods: CCK8, Edu assays and colony formation assay were performed to assess the effect of SBD on PCa cell growth. Effect of SBD on apoptosis and cell cycle was detected by flow cytometry. Transwell and wounding healing assay were performed to detected the invasion and migration activities of PCa cells. Western blot was employed to detect the protein expression. 2RRV1 mouse xenograft model was established to detect the effect of SBD on prostate cancer. Angiogenesis was analysed by coculturing PCa cell lines and HUVECs.Results: The results showed that SBD induced a significant decrease in cell viability and clonogenic growth in a dose-dependent manner. SBD induced cell apoptosis and cell cycle G2/M phase arrest by inactivating PI3K/AKT signalling pathway. Treatment with SBE also significantly decreased the cell migration and invasion via phenotypic inversion of EMT that was characterized by the increased expression of E-cadherin and Vimentin, and decreased expression of N-cadherin, which could be partially attributed to inhibiting PI3K/AKT signalling pathway. Subsequently, using AKT inhibitor MK2206, we performed that PI3K/AKT are also involved in cell apoptosis and metastasis of PCa cells stimulated by SBE. In addition, to its direct effects on PCa cells, SBD also exhibited anti-angiogenic properties. SBD alone or conditioned media from SBD-treated PCa cells inhibited HUVEC tube formation on Matrigel without affecting HUVEC viability. Furthermore, 22RV1 xenograft C57BL/6 mice treated with SBE in vivo showed a significant decrease in tumour size and tumour weight without toxicity. In addition, administration with medium- or high-dose of SBE significantly inhibited the cell proliferation and promoted the damage of tumour tissues.Conclusions: Collectively, our in vitro and in vivo findings suggest that SBE had the potential to develop into a safe and potent alternative therapy for PCa patients.
The Effectiveness of Using Virtual Patient Educational Tools to Improve Medical Students’ Clinical Reasoning Skills: A Systematic
Authors: Plackett Ruth , Kassianos Angelos P. , Mylan Sophie , Kambouri Maria , Raine Rosalind , Sheringham Jessica 
Published: December 2021

Abstract
Background

Use of virtual patient educational tools could fill the current gap in the teaching of clinical reasoning skills. However, there is a limited understanding of their effectiveness. The aim of this study was to synthesise the evidence to understand the effectiveness of virtual patient tools aimed at improving undergraduate medical students’ clinical reasoning skills.
Methods

We searched MEDLINE, EMBASE, CINAHL, ERIC, Scopus, Web of Science and PsycINFO from 1990 to October 2020, to identify all experimental articles testing the effectiveness of virtual patient educational tools on medical students’ clinical reasoning skills. Quality of the articles was assessed using an adapted form of the MERSQI and the Newcastle-Ottawa Scale. A narrative synthesis summarised intervention features, how virtual patient tools were evaluated and reported effectiveness.
Results

The search revealed 7,290 articles, with 20 articles meeting the inclusion criteria. Average study quality was moderate (M=7.1, SD=2.5), with around a third not reporting any measurement of validity or reliability for their clinical reasoning outcome measure (7/20, 35%). Eleven articles found a positive effect of virtual patient tools on reasoning (11/20, 55%). Seven (7/20, 35%) reported no significant effect or mixed effects and two found a significantly negative effect (2/20, 10%). Several domains of clinical reasoning were evaluated. Data gathering, ideas about diagnosis and patient management were more often found to improve after virtual patient use (27/46 analyses, 59%) than knowledge, flexibility in thinking, problem-solving, and critical thinking (4/10 analyses, 40%).
Conclusions

Using virtual patient tools could effectively complement current teaching especially if opportunities for face-to-face teaching or other methods are limited, as there was some evidence that virtual patient educational tools can improve undergraduate medical students’ clinical reasoning skills. Evaluations that measured more case specific clinical reasoning domains, such as data gathering, showed more consistent improvement than general measures like problem-solving. Case specific measures might be more sensitive to change given the context dependent nature of clinical reasoning. Consistent use of validated clinical reasoning measures is needed to enable a meta-analysis to estimate effectiveness.
Macular and Peripapillary Choroidal Thickness Measured by Enhanced Depth Imaging Optical Coherence Tomography in Chinese Pregnant Women and Healthy No-Pregnant Women
Authors: Wu Hanfei , Lin Haishuang , Fang Huanjie , Ruan Mengting , Zhao Jiawei 
Published: December 2021

Abstract
Purpose: To evaluate macular, peripapillary choroidal thickness and retinal nerve fiber layer (RNFL) thickness in different trimesters and compare the measurements with those of healthy non-pregnant women. Methods: A prospective comparative study included 45 healthy pregnant women in first trimester, 90 women in second, 45 women in third trimesters and 45 healthy no-pregnant women as the control group. Macular choroidal thickness was measured at the subfoveal, 1mm temporal and 1mm nasal to the fovea using enhanced depth imaging optical coherence tomography (EDI-OCT). Peripapillary choroidal thickness and RNFL thickness parameters were automatically calculated by the Spectralis OCT. These parameters were analyzed among groups. Results: The subfoveal, temporal and nasal choroidal thickness were all significantly thicker in second trimesters, comparing with those parameters in first, third trimesters and the control group (all P<0.05). The peripapillary choroidal thickness was significantly increased at temporal, nasal, nasal inferior, temporal inferior and global positions during pregnancy among the 4 groups (all P<0.05). The RNFL thickness was also significantly increased in pregnant women at nasal superior and nasal inferior quadrants.Conclusions: Our results suggested that macular choroidal thickening appeared in second trimester. And peripapillary choroidal thickness and RNFL thickness also became thickening in pregnant women comparing with no-pregnant women as a whole.
Melt Pool Features Analysis Using a High Speed Coaxial Monitoring System for Laser Powder Bed Fusion of Ti-6Al-4V Grade 23
Authors: Thanki Aditi , Goossens Louca , Ompusunggu Agusmian Partogi , Bayat Mohamad , Bey-Temsamani Abdellatif , Hooreweder Brecht Van , Kruth Jean-Pierre , Witvrouw Ann 
Published: December 2021

Abstract
In laser powder bed fusion (LPBF), defects such as pores or cracks can seriously affect the final part quality and lifetime. Keyhole porosity, being one type of porosity defects in LPBF, results from excessive energy density which may be due to changes in process parameters (laser power and scan speed) and/or result from the part’s geometry and/or hatching strategies. To study the possible occurrence of keyhole pores, experimental work as well as simulations were carried out for optimum and high volumetric energy density conditions in Ti-6Al-4V grade 23. By decreasing the scanning speed from 1000 mm/s to 500 mm/s for a fixed laser power of 170 W, keyhole porosities are formed and later observed by X-ray computed tomography. Melt pool images are recorded in real-time during the LPBF process by using a high speed coaxial Near-Infrared (NIR) camera monitoring system. The recorded images are then pre-processed using a set of image processing steps to generate binary images. From the binary images, geometrical features of the melt pool and features that characterize the spatter particles formation and ejection from the melt pool are calculated. The experimental data clearly show spatter patterns in case of keyhole porosity formation at low scan speed. A correlation between the number of pores and the amount of spatter is observed. Besides the experimental work, a previously developed, high fidelity finite volume numerical model was used to simulate the melt pool dynamics with similar process parameters as in the experiment. Simulation results illustrate and confirm the keyhole porosity formation by decreasing laser scan speed.
Impact of Urban Expansion On Carbon Storage Under Multi-Scenario Simulations In Wuhan, China
Authors: Wang Zhuo , Zeng Jie , Chen Wanxu 
Published: December 2021

Abstract
Carbon storage in terrestrial ecosystems, which is the basis of the global carbon cycle, reflects the changes in the environment due to anthropogenic impacts. Rapid and effective assessment of the impact of urban expansion on carbon reserves is vital for the sustainable development of urban ecosystems. Previous studies lack research regarding different scenarios during future city and comprehensive analysis on the driving factors from the socioeconomic point of view. Therefore, this study examined Wuhan, China and explored the latent effects of urban expansion on terrestrial carbon storage by combining the Integrated Valuation of Ecosystem Services and Trade-offs (InVEST) and Patch-generating Land Use Simulation (PLUS) model. Based on different socioeconomic strategies, we developed three future scenarios, including Baseline Scenario (BS), Cropland Protection Scenario (CP), and Ecological protection Scenario (EP), to predict the urban built-up land use change from 2015 to 2035 in Wuhan and discussed the carbon storage impacts of urban expansion. The result shows that: (1) Wuhan's urban built-up land area expanded 2.67 times between 1980 and 2015, which is approximately 685.17 km2 and is expected to continuously expand to 1,349–1,945.01 km2 by 2035. (2) Urban expansion in Wuhan has caused carbon storage loss by 5.12×106 t during 1980–2015 and will lead to carbon storage loss by 6.15×106 t, 4.7×106 t, and 4.05×106 t under BS, CP, and EP scenarios from 2015 to 2035, accounting for 85.42%, 81.74%, and 78.79% of the total carbon loss, respectively. (3) The occupation of cropland by urban expansion is closely related to the road system expansion, which is the main driver of carbon storage reduction from 2015 to 2035. (4) We expect that by 2035, the districts facing carbon loss caused by the growth of urban built-up land will expand outward around secondary roads, and the scale of outward expansion under various scenarios will be ranked as: BS >CP > EP. In combination, the InVEST and the PLUS model can assess the impact of urban expansion on carbon storage more efficiently and is conducive to carrying out urban planning and promoting a dynamic balance between urban economic development and human well-being.
Laser Surgery for Treating Retarded Teeth Eruption in Children
Authors: Xu Dan , Wang Peipei , Liu Hualian , Gu Min 
Published: December 2021

Abstract
Objective: To analyze the efficacy of laser surgery in treating retarded eruption in children.Method: Sixty-three children (age：7-13 ，30 boys and 33 girls)were selected and according to the random number table divided into three groups: Laser surgery group (group A), electrosurgery group (group B), and routine surgery group (group C).The total operative time, the duration of pain after gingival excision, and VAS pain intensity scores, gingival healing time, and intraoperative coordination were all recorded . Pain intensity was assessed using a Visual Analogue Scale (VAS) score (0 to 100mm). At six months during the follow-up, this physician checked and recorded the periodontal indicators of permanent teeth, including gum index (GI), plaque index (PLI), and probing depth (PD).Results: All teeth erupted normally in three groups after treatment, showing normal pulp and periodontal tissue. There was no significant difference in operative time, pain duration, pain intensity, healing time between group A and group B. There was a significant difference in total operative time, pain duration, pain intensity, and healing time between electrosurgery group (group B) and routine surgery group (group C) (P<0.05).There was a significant difference in total operative time, pain duration, pain intensity, and healing time between laser surgery group (group A) and routine surgery group (group C) (P<0.05).Periodontal indexes, including gingival indexes, plaque indexes, were examined in three groups at six months after treatment by the same periodontist. Then, the efficacy of the three methods was compared.Conclusion: Laser surgery and high-frequency electrosurgery has favorable efficacy, less pain, and higher operability. However, in the use of the electric knife, the paste flavor may discomfort the children, make them less cooperative, and prolong the procedures.
What are the Environmental Determinants to Participate Among Stroke Survivors in Africa? a Scoping Review
Authors: Assefa Yohannes Awoke , Demeke Zelalem Dessalegn 
Published: December 2021

Abstract
Background

Stroke is the main cause of serious long-term disability worldwide, and it is the second commonest cause of death and a leading cause of adult disability. Two-thirds of stroke cases occur in low- and middle-income countries, which all African countries fall. In Africa, the incidence and survival rate of stroke is increasing. Various personal and environmental factors limit the participation of stroke survivors. As a result, in this review, we aimed to review the environmental factors that are influencing the participation of stroke survivors in Africa.
Methods

Five electronic databases were systematically searched in August 2021 and identified articles were screened by three authors based on predetermined criteria. We followed Arksey and O'Malley (2005) framework and the whole finding is reported using PRISMA-ScR. No date restrictions were imposed, and we included any type of papers including grey literature.
Results

584 articles were generated by our search, after removing duplicates, the title and abstract of 497 articles were screened. From the screening, 42 articles were selected for full article review from which 12 met the criteria to be included. We also manually searched and included one more article for the review.
Conclusion

Studies were mainly conducted in South Africa and assessed the adult population. We followed the International Classification of Functioning, Disability and Health (ICF) framework for the environmental determinants to present our findings. Products and Technology; Natural Environment and Human-Made Changes to Environment; and Services, Systems and Policies found to be a barrier for participation. Conversely, stroke survivors are getting good support from their immediate family and health professionals, which is found to be facilitating. This review could be used by policymakers to understand the environmental barriers that are hindering participation and help to improve the accessibility of the environment so stroke survivors can participate in the community.