bluuebunny/crossref_metadata_2025_split huggingface dataset:
Removal of mechanical ventilation during veno-venous ECMO may improve outcome of patients with acute respiratory failure due to adult community-acquired pneumonia
Authors: Li Lu-Lu , Song Cong-Ying , Shao Mei , Shang An-Dong , Meng Lin-Lin , Lu Yuan-Qiang 
Published: October 2021

Abstract
Background

As a life-saving therapy for patients with acute respiratory failure (ARF)Mechanical ventilation has catalyzed the development of modern emergency medicine and intensive care units.Another way to support respiratory or cardiac functions is extracorporeal membrane oxygenation (ECMO).Based on previous studies, the increased pre-ECMO time of mechanical ventilation is a significant independent predictor of the poorer outcome. Removal or maintaining of mechanical ventilation during ECMO is still debatable.
Methods

We analyzed the clinical data of 23 patients veno-venous ECMO therapy with acute respiratory failure due to adult community-acquired pneumonia.They were divided into two groups: group A (removed of mechanical ventilation, n = 10) and group B ( maintaining of mechanical ventilation,n = 13).Demographic data, including gender, age, smoking habits were collected. General characteristics and Clinical characteristics of patients were also recorded, in order to discuss whether the retention or removal of trachea cannula and continued mechanical ventilation during ECMO can affect patients’ prognosis.
Results

After analysis, patients in the Group B were older than the Group A (61.0 y [54.5–67.5] vs 39.0 y [24.0-61.8], P = 0.021). The median APACHE Ⅱ score of 23 patients before ECMO therapy was 25.0 (IQR, 21.0–28.0), and the Group A had a lower initial APACHE Ⅱ score than the Group B (21.5 [20.8–24.3] vs 28.0 [24.0–29.0], P = 0.005).The group A with a survival rate of 80%, and the group B presenting a survival rate of 23.1%.The difference in the survival rate between the two groups was statistically significant (P = 0.012).No differences in other items were found between the two groups.
Conclusions

The final results showed that the removing of mechanical ventilation during ECMO can improve the survival rate and prognosis in patients with ARF.
In-situ-grown silver–polymer framework with coordination complexes for functional artificial tissues
Authors: Tan Swee Ching , Zhang Songlin , Deng Yibing , Libanori Alberto , Zhou Yihao , Yang Jiachen , Tat Trinny , Yang Lin , Sun Wanxin , Zheng Peng , Zhu Youliang , Chen Jun 
Published: October 2021

Abstract
Sensorized actuators are critical to imitate proprio-/exteroception properties of biological neuromuscular systems. Existing add-on approaches, which physically blend heterogeneous sensor/actuator components, fall short of yielding satisfactory solutions, considering their suboptimal interfaces, poor adhesion, and electronic/mechanical property mismatch. Here, we report a single homogeneous material comprising seamless sensing-actuation unification properties at nano-/molecule levels, in which built-in sensing functions originate from the actuator architecture itself. In-situ-grown silver nanoparticles and metal-ligand complexes cooperatively create a silver–polymer framework (SPF) that is stretchable (1200%), conductive (0.076 S/m), and strong (0.76 MPa in-strength). SPF displays concomitant multimodal sensing (mechanical and thermal cues) and sensorized actuation capabilities, which include proprio-deformation and external stimuli perceptions (simultaneous with load-lifting ability up to 3700× of own weight). In view of its human somatosensitive muscular systems imitative functionality, the reported SPFs bode well for use with next generation functional tissues including artificial skins, human-machine interfaces, self-sensing robots, and otherwise dynamic materials.
Real Life Evaluation of the Multi-organ Effects of Lumacaftor/Ivacaftor on F508del Homozygous Cystic Fibrosis Patients
Authors: Yaacoby-Bianu Karin , Schnapp Zeev , Koren Ilana , Ilivitzki Anat , Khatib Mohamed , Shorbaji Nadeem , Shteinberg Michal , Livnat Galit 
Published: October 2021

Abstract
Background: Lumacaftor/Ivacaftor (LUM-IVA), a cystic fibrosis transmembrane conductance regulator (CFTR) protein corrector-potentiator combination, improves lung function and reduces pulmonary exacerbations (PEx) in F508del homozygous CF patients. However, the systemic effects of LUM-IVA outside the respiratory and nutritional domains have not yet been thoroughly investigated.Methods: A prospective, real-world, one-year study was performed on F508del homozygous adult CF patients who commenced treatment with LUM-IVA. Pancreatic function, bone metabolism, fertility status, nutritional and pulmonary factors were evaluated. Results: 12 patients with a mean age of 28.3 years (18.6-43.9) were recruited. Following 12 months of treatment, no changes were detected in glucose, insulin, c-peptide or BMI values. A significant relative decrease in mean alkaline-phosphatase levels (122.8 U/L vs 108, p=0.008) and a trend toward an increase in calcium levels (9.5 vs 9.8 mg/dL, p=0.0681) were observed. A non-significant improvement in mean DEXA spine t-score after a year of treatment (-2.1 vs -1.6, n=4, p=0.12) was detected. Sweat chloride concentrations decreased significantly after treatment (-21.4 mEq/L; p=0.003). Pulmonary outcome evaluations revealed improvement in spirometry values during the first three months (FEV1 by 5.7% p=0.019, FEF25-75 by 4.3% p=0.035) with no change in chest CT Bhalla score and CFQR after one year. There was also a shift from IV to oral antibiotics for PEx treatment.Conclusions: After a year of treatment, a stabilization was observed in the pancreatic indices, nutritional status, structure and function of the lungs, with a beneficial effect on bone mineral metabolism and CFTR function. Additional studies should investigate the effect of CFTR modulators on extra-pulmonary manifestations.The ClinicalTrials.gov registration number of the study is NCT04623879, registered on 10/11/2020, “retrospectively registered”.
The Effect of Auriculotherapy on Pulmonary Findings and Sleep Quality in Patients with Covid 19
Authors: Mohammadi Maryam , AkhoundiMeybodi Zohreh , Valiani Mahboubeh , Sharifyazdi Mohammad , Asadi Leila , Tarrahi Mohammad Javad , Khani MohammadBagher , mehrjardi Mohammad hosien zare , Khani Alireza 
Published: October 2021

Abstract
Background: Auriculotherapy is a sub-branch of acupuncture and is an effective method in acute and chronic diseases. Aim: The aim of this study was to evaluate the effect of Auriculotherapy on pulmonary findings and sleep quality in patients with Covid 19.Methods: The present study is a clinical trial study in which 70 hospitalized patients with Covid 19 with pulmonary findings and low sleep quality were randomly divided into intervention and control groups. Auriculotherapy was performed with electrical stimulation in one session and then Vakaria seed was placed in acupressure points and stimulated for one week (8 times a day for one minute each time). Data collection tools were checklist of pulmonary findings, Pittsburgh questionnaires and demographic characteristics.Results: The results showed that there was no significant difference between the mean SPO2 score in the two groups before and after the intervention (P = 0.09). There was a statistically significant difference between the mean score of dyspnea (P = 0.003), cough (P <0.008) and overall score of sleep quality in the two groups before and after the intervention (P <0.001).Conclusion: The results of this study showed that Auriculotherapy is effective on pulmonary improvements and sleep quality in patients with Covid 19.Trial registration: IRCT, IRCT20180608040007N2. Registered 13 June 2020, https://en.irct.ir/trial/48218.
Silicon Improves Ion Homeostasis and Growth of Liquorice (Glycyrrhiza Uralensis Fisch. and Glycyrrhiza Inflata Bat.) Under Salt Stress by Reducing Plant Na+ Uptake
Authors: Shen Zihui , Pu Xiaozhen , Wang Shaoming , Dong Xiuxiu , Cheng Xiaojiao , Cheng Moxiang 
Published: October 2021

Abstract
Silicon effectively alleviates the damage caused by salt stress in plants and can improve plant salt tolerance. However, the details of the mechanism by which silicon improves salt tolerance of liquorice are limited, and the effects of foliar application of silicon on different liquorice species under salt stress are not known. Here, the effects of foliar spray of silicon on the growth, physiological and biochemical characteristics, and ion balance of Glycyrrhiza uralensis Fisch. and Glycyrrhiza inflata Bat. were investigated. High salt stress resulted in the accumulation of a large amount of Na+, decreased photosynthetic pigment content, perturbed ion homeostasis, and eventually inhibited the both liquorice species growth. These effects were more pronounced in G. uralensis, as G. inflata is more salt tolerant than G. uralensis. Foliar spraying of silicon effectively reduced the decomposition of photosynthetic pigments, improved gas exchange parameters, and promoted photosynthesis. It also effectively inhibited lipid peroxidation and electrolyte leakage and enhanced osmotic adjustment of plants. Further, silicon application increased the K+ concentration, reduced Na+ absorption, transport and accumulation in the plants. The protective effects of silicon were more pronounced in G. uralensis than those in G. inflata. In conclusion, silicon reduces Na+ absorption, improves ion balance, and alleviates the negative effects of salt stress in the two liquorice species studied, but the effect is liquorice species-dependent. These findings may inform novel strategies for protecting liquorice plants against salt stress and also provide a theoretical basis for the evaluation of salt tolerance and the scientific cultivation of liquorice.
Bisphosphonates prevents the bone mineral loss in lymphoma patients treated with glucocorticoids: a prospective, randomized controlled phase 3 trial in China
Authors: Yang Chunli , Fu Chunxi , Weng Huawei , Zou Liqun 
Published: October 2021

Abstract
Background

Glucocorticoids-containing regimens are the standard first line treatment for most lymphoma patients, however, as the improvement of overall survival in these cases, glucocorticoids related osteopenia or osteoporosis attracted attention in clinical administration. We aim to investigate the efficacy of bisphosphonates in prevention bone mineral loss in glucocorticoids-treated lymphoma patients.
Methods

This is a prospective, randomized controlled phase 3 trial. Eligible lymphoma adults from China with first line glucocorticoids involved treatment, were randomly assigned 1:1 to receive either Zoledronic acid (ZA) for twice infusion or not. All patients received daily oral calcium and vitamin D3 for one year. The primary endpoint, alternations of bone mineral loss from enrollment to the twelfth month at the lumbar spine (L1-L4), left hip and left femoral neck, measured by the dual-energy, x-ray absorptiometry scanners, recorded as T score; and new bone fractures during the first year, were analyzed by intent-to-treat. This trial was registered with www.Chictr.org, number ChiCTR-INR-17010771.
Results

Between May, 2016 to July, 2019, 84 patients were randomly assigned to both Zoledronic acid and control groups, 29 patients completed the study and were on follow-up. We found a marked improvement of T score in ZA group compared with the control in a year at lumbar spine, T score changes of L1-4 in ZA group and control group were as following: L1, 0.14±0.61 vs. -0.33±0.40, p=0.009; L2, 0.28±0.41 vs. -0.35±0.54, p=0.003; L3, 0.23±0.42 vs. -0.23±0.66, p=0.020; L4, 0.28±0.44 vs. -0.35±0.54, p=0.020. Meanwhile, no severe adverse event was observed on both groups.
Conclusions

Glucocorticoids-treatment lymphoma patients that prophylactic ZA infusion could relieve BMD loss to prevent osteoporosis without increasing severe adverse effects in Chinese population, providing reference for clinicians to consider ZA application in this situation.
Role of Integrated Information Technology for Responses to Violence Against Women and Children During Covid-19 Pandemic
Authors: Mohammadzadeh Zeinab , Maserat Elham 
Published: October 2021

Abstract
Background: The restriction and quarantine due to Covid-19 has led to unprecedented disruptions in the lives of women and children. Due to the increase in violence against women and children, the using of e-health has been considered to provide supportive care in this area. The purpose of this paper is developing comprehensive evidence-based framework of e-health intervention to response women and child violence.Methods: The methodology of this study was based on a two-stage which included literature review at the beginning. In first step a comprehensive review performed for extracting studies that survey the effectiveness of information technology in managing violence against women and child. Researches extracted appropriate articles and summarized important component. The review steps included set questions, search strategy and inclusion/exclusion criteria. The framework was defined based on the literature review and social-ecological model (SEM).Result: The finalized framework for application IT-based interventions in the management of violence against women and children presented in 4 dimension including individual, relationship, community and societal. The first and second levels of this model include 4 dimensions of SEM and 6 types of violence. The third level includes suggestions for managing violence and the fourth level includes IT-based interventions. Surveillance system and information resource system can be used for monitoringConclusion: During Covid-19, domestic violence and economic pressures increased, and vulnerable women and children were at greater risk. It is critical to identify people at risk, to follow and monitor them, to raise the awareness and knowledge of these people, and to empower and provide psychosocial support to these people during this period. In this study, a comprehensive review of IT-based interventions was presented and finally an international framework in this field was described.
Predictive Value of Lymphocyte-to-Monocyte Ratio in Patients with Atrial Fibrillation: A Propensity Score Matching Analysis
Authors: Yu Yue , Wang Suyu , Wang Pei , Xu Qiumeng , Zhang Yufeng , Xiao Jian , Xue Xiaofei , Yang Qian , Xi Wang , Wang Junnan , Huang Renhong , Liu Meiyun , Wang Zhinong 
Published: October 2021

Abstract
Background

Inflammation plays a key role in the initiation and progression of atrial fibrillation (AF). Lymphocyte-to-monocyte ratio (LMR) has been proved to be a reliable predictor of many inflammation-associated diseases, but little data are available on the relationship between LMR and AF. The present study aimed to evaluate the predictive value of LMR in predicting all-cause mortality among AF patients.
Methods

Data of patients diagnosed with AF were retrieved from the Medical Information Mart for Intensive Care-III (MIMIC-III) database. X-tile analysis was used to calculate the optimal cutoff value for LMR. The Cox proportional-hazards regression model was used to assess the association of LMR and 28-day, 90-day and 1-year mortality. Additionally, a propensity score matching (PSM) method was performed to minimize the impact of potential confounders.
Results

A total of 3,567 patients hospitalized with AF were enrolled in this study. The X-tile software indicated that the optimal cutoff value of LMR was 2.67. A total of 1,127 pairs were generated and all the covariates were well balanced after PSM. The Cox proportional-hazards model showed that patients with the low LMR (≤ 2.67) had a higher 1-year all-cause mortality than those with the high LMR (> 2.67) in the study cohort before PSM (HR = 1.640, 95% CI: 1.437–1.872, P < 0.001) and after PSM (HR = 1.279, 95% CI: 1.094–1.495, P = 0.002). The multivariable Cox regression analysis for 28-day and 90-day mortality yielded similar results.
Conclusions

The lower LMR (≤ 2.67) was associated with a higher risk of 28-day, 90-day, and 1-year all-cause mortality, which might serve as an independent prognostic predictor in AF patients.
Impact of the Specific Activity and PSMA Expression Level on 18F-AlF-PSMA-11 Uptake in Prostate Cancer
Authors: Piron Sarah , Verhoeven Jeroen , De Coster Emma , Descamps Benedicte , Kersemans Ken , Pieters Leen , Vral Anne , Vanhove Christian , De Vos Filip 
Published: October 2021

Abstract
This two-part preclinical study aims to evaluate prostate specific membrane antigen (PSMA) as a valuable target for expression-based imaging applications and to determine changes in target binding in function of varying specific activities (SA) of 18F-AlF-PSMA-11. For the evaluation of PSMA expression levels, male NOD/SCID mice bearing prostate cancer (PCa) xenografts of C4-2 (PSMA+++), 22Rv1 (PSMA+) and PC-3 (PSMA-) were administered 18F-AlF-PSMA-11 with a medium SA (20.26 ± 3.25 MBq/µg). SUVmean and SUVmax values were respectively 3.22 and 3.17 times higher for the high vs low PSMA expressing tumors (p < 0.0001). To evaluate the effect of varying SA, C4-2 and 22Rv1 xenograft bearing mice underwent additional 18F-AlF-PSMA-11 imaging with a high (213.3 ± 39.3 MBq/µg) and/or low SA (1.94 ± 0.27 MBq/µg). SUV values showed a significantly increasing trend with higher SA. Significant changes were found for SUVmean and SUVmax between the high vs low SA and medium vs low SA (both p < 0.05), but not between the high vs medium SA (p = 0.055 and 0.25, respectively). The effect of varying SA was more pronounced in low expressing tumors and PSMA expressing tissues (e.g. salivary glands and kidneys). Overall, administration of a high SA increases the detection of low expression tumors while also increasing uptake in PSMA expressing tissues, possibly leading to false positive findings. In radioligand therapy, a medium SA could reduce radiation exposure to dose-limiting organs with only limited effect on radionuclide accumulation in the tumor.
Rational Designed Rapid Liver Clearance Rare-earth Core-shell Nanoprobe for Dual-Modal Breast Cancer Imaging in the Second Near-Infrared Window
Authors: Wei Zhuxin , Duan Guangxin , Huang Baoxing , Qiu Shanshan , Zhou Dandan , Zeng Jianfeng , Cui Jiabin , Hu Chunhong , Wang Ximing , Wen Ling , Gao Mingyuan 
Published: October 2021

Abstract
BackgroundFluorescence imaging as the beacon for optical navigation has wildly developed in preclinical studies due to its prominent advantages, including noninvasiveness and superior temporal resolution. However, the traditional optical methods based on ultraviolet (UV, 200-400 nm) and visible light (Vis, 400-650 nm) limited by their low penetration, signal-to-noise ratio, and high background auto-fluorescence interference. Therefore, the development of near-infrared-II (NIR-II 1000-1700 nm) nanoprobe attracted significant attentions toward in vivo imaging. Regrettably, most of the NIR-II fluorescence probes, especially for inorganic NPs, were hardly excreted from the reticuloendothelial system (RES), yielding the anonymous long-term circulatory safety issue. ResultsHere, we develop a facile strategy for the fabrication of Nd3+-doped rare-earth core-shell nanoparticles (Nd-RENPs), NaGdF4:5%Nd@NaLuF4, with strong emission in the NIR-II window. What’s more, the Nd-RENPs could be quickly eliminated from the hepatobiliary pathway, reducing the potential risk with the long-term retention in the RES. Further, the Nd-RENPs are successfully utilized for NIR-II in vivo imaging and magnetic resonance imaging (MRI) contrast agents, enabling the precise detection of breast cancer. ConclusionsThe rational designed Nd-RENPs nanoprobes manifest rapid-clearance property revealing the potential application toward the noninvasive preoperative imaging of tumor lesions and real-time intra-operative supervision.
Exploring the mechanisms of Drynariae Rhizoma on treating memory impairment through network pharmacology
Authors: Liu Wangmi , Wu Jiayan 
Published: October 2021

Abstract
Background

Memory impairment continues to be a major health problem and increases with age, especially in the elderly population worldwide. However, a causal mechanism has not been clearly identified. Currently, an interaction between bone and brain, the so-called “bone-brain crosstalk,” has emerged. We used a network pharmacology approach to explore the potential mechanisms of Drynariae Rhizoma (DR), a traditional Chinese medicine for fracture treatment, for therapeutic intervention of human conditions associated with memory impairment.
Methods

The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was used to screen out the active compounds of DR, and the targets of the active compounds were predicted using PharmMapper. Targets related to memory impairment were downloaded from the DisGeNET database. The compound-target network and protein-protein interaction network were built by NetworkAnalyst and Cytoscape software. Gene ontology analysis and Reactome pathway enrichment analysis were performed using NetworkAnalyst. SYBYL-X software was used to perform molecular docking simulation.
Results

Our study demonstrated that DR had 7 active compounds. There were 60 target genes related to these active compounds as well as to memory impairment. Signalling by nerve growth factor was among the top 3 enriched Reactome terms. Akt1 was an important signalling hub gene belonging to signalling by nerve growth factor pathway. Molecular docking results showed that the one of the active compounds, xanthogalenol, exhibited acceptable affinities to Akt1.
Conclusion

This study demonstrated the molecular mechanism that DR may alleviate memory impairment via regulation of Akt1 and signalling by nerve growth factor pathway. These results offer new ideas in searching for novel strategies for the treatment of memory impairment.
Chronic Xiao-chai-hu Decoction Therapy Slows the Progression of Acute-on-chronic Liver Failure via Prokinetic Effects on Gastrointestinal Motility
Authors: Ye Feng , Zhang Jian , Wang Yi-long , Lin Shu-mei , Zhang Xi , Liu Xiao-jing , Li Jian-zhou , liu yi 
Published: October 2021

Abstract
BackgroundAcute-on-chronic liver failure (ACLF) has a high risk of mortality in liver diseases without effective treatment. Xiao Chai Hu decoction (XCHD) is a traditional herbal formula, widely administered for liver disease, including anti-hepatic fibrosis and anti-inflammatory. MethodsTo investigate whether XCHD prevents the progression of ACLF and the underlying mechanisms. Methods: Sprague–Dawley rats with compound factors were randomly divided into model control group with 30 rats and four treatment groups with 20 rats in each group: Polyene phosphatidylcholine (100 mg/kg; PP) group; high dose (44.5 g/kg; HXCHD), middle dose (26.5 g/kg; MXCHD), and low dose (8.5 g/kg; LXCHD). Firstly, liver disease progression after XCHD treatment was measured by detecting: 1) the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TB), and albumin, prothrombin time (PT); 2) the survival rate and rat-adapted model for end-stage liver disease (MELD) score; 3) the hepatic hyperplastic collagen fibers with Masson’s trichrome staining; 4) the serum level of TNF-α and endotoxin induced hepatocyte apoptosis expression; 5) the ileum slow waves, gastric emptying, and small intestinal transit after XCHD treatment. ResultsThe XCHD groups showed improved serum biochemical hepatic parameters, histological liver changes, and survival rate. In addition, the XCHD treatment decreased the serum level of TNF-α and endotoxin and reduced hepatocyte apoptosis. XCHD decreased the normal percentage ileum slow waves, prolonged gastric emptying, and increased the small intestinal transit of ACLF. ConclusionsXCHD prevented the progression of ACLF partially via the prokinetic effects on gastrointestinal motility to reduce TNF-α, endotoxin, and hepatocyte apoptosis.