bluuebunny/crossref_metadata_2025_split huggingface dataset:
The beneficial short‐term effects of a high‐protein/low‐carbohydrate diet on glycaemic control assessed by continuous glucose monitoring in patients with type 1 diabetes
Authors: Dimosthenopoulos Charilaos , Liatis Stavros , Kourpas Elias , Athanasopoulou Elpida , Driva Stamatina , Makrilakis Konstantinos , Kokkinos Alexander 
Published: March 2021

AbstractAimTo compare the effects of three different but isocaloric dietary patterns, high‐protein/low‐carbohydrate (HPD) with 20% of calories as carbohydrates, Mediterranean/low glycaemic index (MED) with 40% carbohydrates, and a reference diet (REF) with 50% carbohydrates, in patients with type 1 diabetes (T1D).Materials and MethodsIn a randomized crossover study, 15 patients with T1D were assigned to the three dietary patterns for three separate weeks, with 7‐day washout periods in between. Continuous glucose monitoring was applied during the intervention periods. The primary outcome was glycaemic control, as measured by the percentage of time patients spent within the euglycaemic range (TIR70–140 mg/dl). Other key glycaemic metrics were also investigated as secondary outcomes.ResultsTIR70–140 was not statistically different between HPD, MED and REF (p = .105). Pairwise analysis revealed a statistically significant difference between HPD and REF at the .05 level, which was not retained after applying Bonferroni correction (54.87% ± 14.11% vs. 48.33% ± 13.72%; p = .018). During the HPD period, 11 out of 15 participants spent more time within TIR70–140 compared with either the REF or MED. The HPD performed significantly better than the REF in terms of TIR70–180 (74.33% ± 12.85% vs. 67.53% ± 12.73%; p = .012), glycaemic variability (coefficient of variation: 36.18% ± 9.30% vs. 41.48% ± 8.69%; p = .016) and time spent in the hypoglycaemic range (TBR70 mg/dl; median: 12, IQR: 16 vs. median: 14, IQR: 20; p = .007), whereas no statistically significant differences were observed between MED and HPD or REF.ConclusionsCompared with REF and MED, an HPD plan may have a positive impact on glycaemic control in patients with T1D. During the HPD, patients spent a shorter time in hypoglycaemia and exhibited lower glycaemic variability.
CircRUNX1 functions as an oncogene in colorectal cancer by regulating circRUNX1/miR‐485‐5p/SLC38A1 axis
Authors: Yu Juan , Chen Xiaoguang , Li Jing , Wang Furang 
Published: March 2021

AbstractBackgroundCircular RNAs (circRNAs) have emerged as vital regulators in human cancers, including colorectal cancer (CRC). In this study, we aimed to explore the roles of circRUNX1 in CRC.MethodsThe levels of circRUNX1, RUNX1 mRNA, solute carrier family 38 member 1 (SLC38A1) mRNA and microRNA‐485‐5p (miR‐485‐5p) were determined by quantitative real‐time polymerase chain reaction (qRT‐PCR) analysis. The protein level of SLC38A1 was measured by Western blot assay. Cell colony formation, migration, invasion and apoptosis were assessed by colony formation assay, wound‐healing assay, Transwell assay and flow cytometry analysis, respectively. The interaction between miR‐485‐5p and circRUNX1 or SLC38A1 was verified by dual‐luciferase reporter assay and RNA immunoprecipitation (RIP) assay. The levels of extracellular glutamine, intracellular glutamate and α‐ketoglutarate (α‐KG) were measured with specific kits. The functional role of circRUNX1 in CRC development in vivo was explored by murine xenograft model assay.ResultsCircRUNX1 was upregulated in CRC tissues and cells compared with normal tissues and cells. CircRUNX1 deficiency restrained CRC cell colony formation, migration, invasion and glutaminolysis and induced apoptosis in vitro as well as blocked tumour growth in vivo. CircRUNX1 directly sponged miR‐485‐5p, which negatively modulated SLC38A1 expression in CRC cells. The effects of circRUNX1 knockdown on CRC cell colony formation, migration, invasion, apoptosis and glutaminolysis were reversed by miR‐485‐5p inhibition. Moreover, miR‐485‐5p overexpression repressed the malignant behaviours of CRC cells, with SLC38A1 elevation overturned the impacts.ConclusionCircRUNX1 promoted CRC cell growth, metastasis and glutamine metabolism and repressed apoptosis by elevating SLC38A1 through sponging miR‐485‐5p, which might provide a novel target for CRC treatment.
Changes in land use affect dung beetle communities but do not affect ecosystem services in the Cerrado of Central Brazil
Authors: Oliveira Yuri F. , Oliveira Charles M. , Frizzas Marina R. 
Published: March 2021

1. Changes in land use have been identified as one of the main drivers of global biodiversity loss, and also negatively affect ecosystem services. Dung beetles are capable of providing a variety of ecosystem services and can be used as bioindicators.2. We assess whether the land use changes of the Cerrado areas for agricultural purposes (pasture and soybean crops) affects dung beetle community and the associated ecosystem services (dung removal and secondary seed dispersal) provided by dung beetles on their diversity in the Federal District, Brazil.3. A total of 32 261 individuals (Scarabaeinae, Aphodiinae and Anaidinae) were collected. The abundance and biomass of dung beetles were significantly higher in soybean (n = 19 354; biomass = 1145.4 g) and pasture (n = 9865; biomass = 753.6 g) compared to cerrado (n = 3042; biomass = 311.6 g). Sixty‐one species were collected in the cerrado, 58 in soybean and 56 in pasture, most species were paracoprids (52–60%), but no significant differences were observed for the species richness and diversity indices among the different land use systems. The structure of the dung beetle community in areas of the cerrado was distinct from that in pasture and soybean areas, and the latter two were similar. The land use systems did not affect the ecosystem services provided by dung beetles.4. Our results showed that the Cerrado dung beetle community was unique and specific, indicating an imperative need for its preservation, due to its intrinsic value and its importance for the functioning of the ecosystem.
P‐SCADA ‐ A novel area and energy efficient FPGA architectures for LSTM prediction of heart arrthymias in biot applications
Authors: Varadharajan Senthil Kumaran , Nallasamy Viswanathan 
Published: March 2021

AbstractRecurrent neural networks (RNN) are extensively used to determine the optimal solutions to the various class recognition problems such as image processing, prediction of biomedical data and speech recognition. With the gradient problems, RNN is slowing losing its shade which is replaced by the Long short term memory (LSTM). However the hardware implementation of the LSTM requires more challenge due to its complexity and high power consumption which makes it unsuitable for implementing in Biological Internet of things networks for prediction of heart diseases. Several algorithms were proposed for an effective implementation of LSTM, but hand‐offs between the performance and utilization still needs improvisation. The paper proposes the novel energy efficient and high performance architecture Pipelined Stochastic Adaptive Distributed Architectures (P‐SCADA) for LSTM networks. In this architecture, hybrid structure has been developed with the help of new distributed arithmetic stochastic computing (DSC) along with the binary circuits to advance the performance of the FPGA such as energy, area and accuracy. The proposed system has been implemented in ARTIX‐7 FPGA with special purpose software has been designed and evaluated with different ECG datasets. For the different series data, area utilization is about 40%–44% and power consumption is about 20%–25% with the prediction of accuracy of 98%. Moreover the proposed architecture has been compared with the other existing architecture such as SPARSE architectures, normal stochastic architectures in which the proposed architecture excels in terms area, power and efficiency.
Family Dynamics in Dementia Caregiving: Development and Validation of the Interpersonal Triggers of Guilt in Dementia Caregiving Questionnaire (ITGDCQ)
Authors: Gallego‐Alberto Laura , Losada AndrÉs , MÁrquez‐GonzÁlez MarÍa , Romero‐Moreno Rosa , Cabrera Isabel 
Published: March 2021

The objective was to develop the Interpersonal Triggers of Guilt in Dementia Caregiving Questionnaire (ITGDCQ). An emotion frequently experienced by caregivers is guilt. However, the studies analyzing potential factors that generate guilt are scarce. Guilt may be generated through interpersonal interactions. A total of 201 dementia caregivers were evaluated for frequency of leisure, guilt, anxiety, depression, and a pool of items measuring the frequency, and guilt was derived from different behaviors performed by the care recipient (ITGDCQ‐CR) and other relatives (ITGDCQ‐OR). Exploratory factor analysis of the ITGDCQ‐CR showed a two‐factor solution, explaining 56.24% of the variance. The ITGDCQ‐OR subscale also showed two factors, explaining 63.24% of the variance. All the factors had acceptable to good reliability indexes. Positive associations were found between both subscales and depression, anxiety, guilt, and stress associated with CR’s behavioral problems. ITGDCQ‐CR was negatively correlated with frequency of leisure. The interpersonal dynamics assessed with the ITGDCQ generated other emotions such as anger or sadness. Through structural equation modeling, 28% of the variance of caregivers’ distress was explained by the assessed variables, including a significant contribution of the interpersonal dynamics assessed with the ITGDCQ. The results provide preliminary support for the use of the ITGDCQ as a valid and reliable measure of care recipients’ or other relatives’ factors that trigger or facilitate the experience of guilt in the caregivers. The association between these factors and caregiver distress suggests potential clinical implications for the findings.
Pasture legumes differ in herbage production and quality throughout spring, impacting their potential role in fodder conservation and animal production
Authors: Hackney Belinda , Rodham Craig , Dyce Gabrielle , Piltz John 
Published: March 2021

AbstractThis study reports on the herbage production and quality of a range of pasture legume species during spring, at three sites with moderate to strongly acidic soils in southern NSW, Australia. These data have enabled prediction of livestock production when legumes are conserved as silage or hay. Total herbage production, its timing and quality differed significantly between species, which generally was not predicted by the traditional metric of time to flowering. Trifolium incarnatum L., T. michelianum L., Biserrula pelecinus L., Ornithopus sativus Brot. and Hedysarum coronarium L. all maintained growth rates exceeding 200 kg DM/ha/d for 4 weeks over spring, while T. vesiculosum Savi. maintained this for 6 weeks, with a peak growth rate of 561 kg DM/ha/d. Herbage quality of all species declined over time and was greatest in species with a rapid increase in stem‐to‐leaf ratio or with weak stems, resulting in lodging. The modelling inferred that maximizing potential livestock production via fodder conservation required earlier cutting. Only the indeterminate species B. pelecinus and Ornithopus spp. increased potential liveweight gain per hectare through delayed harvesting from (probable) silage to hay‐making time.
Root growth response of serradella species to aluminium in solution culture and soil
Authors: Kidd Daniel R. , Ryan Megan H. , Colmer Timothy D. , Simpson Richard J. 
Published: March 2021

AbstractSerradella (Ornithopus) species are high‐quality pasture legumes that originate from the Mediterranean basin and have been increasingly used in southern Australian temperate grazing systems. They are generally regarded as tolerant of soils with low pH and, by inference, elemental toxicities such as aluminium (Al). No studies have examined the effect of high Al concentrations on the growth of French serradella (Ornithopus sativus Brot.) or newly developed cultivars of yellow serradella (O. compressus L.). Several cultivars/accessions of each species were grown in low ionic‐strength nutrient solutions at pHCa 4.5 containing a range of Al concentrations. Their susceptibility to root growth inhibition by Al was benchmarked against reference species ranging from Al‐sensitive to Al‐tolerant. Most serradella cultivars had moderate‐to‐high Al tolerance in solution culture but one yellow and two French serradella cultivars ranked alongside the Al‐sensitive reference species. A subset of cultivars and reference species were then grown in an Al‐toxic soil to test the validity of the solution culture results; these cultivars spanned the apparent range in Al sensitivity/tolerance indicated by the solution culture experiment. Variation in the relative root length achieved in Al‐toxic solution culture explained ~59% of the variation in the relative root length achieved in the acidic Al‐toxic soil. This result supports the conclusion that Al tolerance varies among serradella and that some cultivars may not thrive in soils with pHCa < 4.5 and elevated extractable Al concentrations.
Effect of tongue piercing on periodontal and peri‐implant health: A cross‐sectional case‐control study in adults
Authors: Ibraheem Wael I. , S Preethanath Reghunathan , Devang Divakar Darshan , Al‐Askar Mansour , Al‐Kheraif Abdulaziz A. 
Published: March 2021

AbstractObjectivesThe authors hypothesize that periodontal and peri‐implant inflammatory parameters are poorer in adult patients with tongue piercing compared with controls. The aim was to assess the influence of tongue piercing on periodontal and peri‐implant health status in adults.MethodsTest and control groups comprised of individuals with and without tongue piercing, respectively. A questionnaire was used to collect information about gender, age, duration of tongue piercing and implants in function, jaw location of the implant, reasoning for wearing the tongue ornament, and oral hygiene and ornament cleaning habits. Full‐mouth and peri‐implant plaque index (PI), gingival index (GI), clinical attachment loss (CAL), probing depth (PD) and marginal/crestal bone loss (MBL and CBL, respectively) on mesial and distal surfaces of teeth/implants were recorded. The material (plastic or metal) from which, the bar and ball‐ends of the ornament were fabricated was also recorded. A p < 0.01 was considered statistically significant.ResultsForty‐eight and 49 individuals were included in the test and control groups, respectively. There was no difference in PI, GI, PD, CAL and MBL (mesial and distal) among individuals in the test and control groups. In the test group, peri‐implant PI (p < 0.01), GI (p < 0.01), PD (p < 0.01) and mesial (p < 0.01) and distal (p < 0.01) CBL were significantly higher in the anterior mandible compared with implants in other jaw locations. In the control group, there was no difference in peri‐implant PI, GI, PD and CBL around implants placed in both jaws.ConclusionWearing tongue piercings could increase the risks of periodontal and peri‐implant diseases particularly in the mandibular anterior segment.
Studying the in vitro corrosion response of nanostructured TaN coatings in Hank's physiological solution
Authors: Babaei Kazem , Fattah‐alhosseini Arash , Elmkhah Hassan , Imantalab Omid , Ghomi Hamidreza 
Published: March 2021

AbstractThe goal of this research is to determine the effect of N2 pressure to argon pressure on the microstructural analysis and corrosion behavior of nanostructured TaN deposited coatings using a reactive DC‐magnetron sputtering (RDCMS) technique. The samples coated microstructure was studied by the X‐ray diffraction (XRD) and scanning electron microscope (SEM), and elemental distribution was studied using energy‐dispersive X‐ray spectroscopy (EDS). To investigate the corrosion behavior of nanostructured TaN coatings, the potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS) tests were performed in Hank's physiological solution. The results of different tests revealed that the coating with a content of 17.6% PN2/PAr consisted of hexagonal and orthorhombic TaN phases and had denser microstructure and free pores. This coating showed superior corrosion behavior in comparison to the other ones. Also, the corrosion resistance of this coating raised by increasing the time of immersion from 48 to 168 h.
Service quality in the sharing economy: A review and research agenda
Authors: Akhmedova Anna , Manresa Alba , Escobar Rivera Dalilis , Bikfalvi Andrea 
Published: March 2021

AbstractThe growth of sharing economy (SE) business models across different sectors suggests global shifts in consumer expectations, values, behaviours and lifestyles. SE products and service are not standardized, and it is impossible to talk about quality as it is traditionally understood. The methodological and theoretical approaches to study the quality in this setup remain segmented. This warrants a revision and systematization of existing knowledge. We use a hybrid review based on integration of bibliometric and structured reviews. We identify research streams, theoretical frameworks, contexts and methods related to perceived service quality in the SE, and also detect current gaps and formulate future research directions.
Success drivers of co‐branding: A meta‐analysis
Authors: Paydas Turan Ceyda 
Published: March 2021

AbstractWhile considerable research attention has been given to co‐branding (brand alliance), empirical evidence of the success drivers remains fragmented with inconclusive findings. This meta‐analysis aims to synthesize the existing research and provide a comprehensive and generalisable set of findings. It integrates data of 197 effect sizes from 37 independent studies reported in 27 articles. The findings reveal that the relationship between the partner brands has a significantly larger impact on the success of co‐branding than the individual brand characteristics, and brand image fit is a relatively more important driver than product category fit and brand equity. Moderator analysis indicates that the relative importance of the relationship between brands is generalisable to the type of industry, business and co‐branding strategy. This paper advances theoretical understanding in three ways: (a) it increases generalisability of existing studies by investigating the impact of theoretical, contextual, and method‐related moderators on the effect sizes, (b) it brings a consensus to the equivocal findings on the importance of success drivers and (c) it identifies the knowledge gaps, and presents a future research agenda. In so doing, the paper guides practitioners by highlighting which factors to be considered and prioritised when forming a brand alliance.
Functional outcomes after robot‐assisted radical cystectomy: A review of literature
Authors: Iqbal Umar , Durrani Mohammad M , Elsayed Ahmed S , Hussein Ahmed A , Shigemura Katsumi , Fujisawa Masato , Guru Khurshid A 
Published: March 2021

AbstractRobot‐assisted radical cystectomy has steadily gained wider acceptance among urologists compared with open and laparoscopic approaches. Robot‐assisted radical cystectomy has shown comparable perioperative and oncologic outcomes compared with open radical cystectomy. Nevertheless, data about the functional outcomes and quality of life after robot‐assisted radical cystectomy remain limited. We sought to review the literature and describe urinary, sexual and bowel functions after robot‐assisted radical cystectomy in addition to mental health and health‐related quality of life. Despite limitations of the available literature, data suggests that functional outcomes after robot‐assisted radical cystectomy are comparable to open radical cystectomy. However, more studies utilizing standardized definitions are required.
Selection approaches to the variation of responses to soil compaction stress among maize hybrids (Zeamays L.)
Authors: Grzesiak Maciej T. , Maksymowicz Anna , Jurczyk Barbara , Hura Tomasz , Rut Grzegorz , Rzepka Andrzej , Grzesiak Stanisław 
Published: March 2021

AbstractSoil compaction stress can strongly affect plant growth, development and productivity. Effects of different levels of soil compaction were investigated in 18 maize hybrids during field and greenhouse experiments. Maize hybrids in the field experiments were subjected to low (L) or high (H) and in the greenhouse experiments to low (L: 1.10) and high (C: 1.60 g cm−3 soil) soil compaction level. Differences between maize hybrids grown under non‐stress and stress conditions were found in a decrease in grain yield (GY), grain number (GN), weight of 1,000 grain (W‐1000), seedling dry matter (DM), emergence (EM), plant height (H), leaf area (LA) and leaf greening (SPAD). Stress susceptibility index (SSI), geometric mean productivity index (GMP) and tolerance index (TI) were evaluated by determining the effects of low (L) or high (H) soil compaction levels on grain yield (GY) or dry matter of the above‐ground part (DM). The values of SSI, GMP and TI enabled us to rank the tested hybrids with respect to their susceptibility to soil compaction stress. SSI and TI made it possible to identify maize hybrids resistant and sensitive to soil compaction stress. Changes in growth traits were greater in the hybrids with high SSI and TI. Correlation coefficient (r) between stress susceptibility index (SSI) of maize hybrids in the field and greenhouse experiment was high and statistically significant. This observation may indicate that genetically determined susceptibility to soil compaction stress in maize hybrids was similar throughout ontogenesis.
Global distribution of microwhip scorpions (Arachnida: Palpigradi)
Authors: Mammola Stefano , Souza Maysa Fernanda Villela Rezende , Isaia Marco , Ferreira Rodrigo Lopes 
Published: March 2021

AbstractAimHistorically, research on global distribution patterns has mostly concentrated on conspicuous organisms and thus a large proportion of biodiversity on Earth remains unmapped. We examined the global distribution of palpigrades, a poorly studied group of low dispersive arachnids specialized to subterranean life. We asked what are the ecological factors driving their distributions, and to what extent sampling bias may influence the observed patterns.LocationGlobal.TaxonPalpigrades (Arachnida: Palpigradi) in the genusEukoenenia.MethodsWe assembled a database of over 1000 localities and referring to 57 soil‐ and 69 cave‐adapted palpigrades. We tested for differences in range sizes of soil‐ and cave‐adapted species. We used variance partitioning analysis to explore the contribution of climate, nutrient availability and geology in driving observed distributions. Finally, we verified the potential correlation between the number of occurrence records and the number of palpigrades' researchers.ResultsEurope and Brazil emerged as centres of diversification of cave‐adapted palpigrades. Conversely, the diversity of soil‐adapted species was distributed over a broader geographical expanse, mainly in the Southern Hemisphere. Both cave and soil species had narrow distribution ranges, with a median value of 0.01 km2; only a few parthenogenetic species were distributed over multiple continents. The distribution of cave‐ and soil‐adapted palpigrades was primarily explained by climatic conditions, and secondarily by nutrient and habitat availability. In the Alps, the distribution of cave‐adapted species also bears the signature of historical events related to glaciation cycles. We observed, however, a pronounced people‐species correlation, suggesting that the observed patterns are not generalizable to poorly explored areas.Main conclusionsOur study highlights enormous gaps in current knowledge about the biogeography of palpigrades. Even if the information is largely incomplete and biased, we show how data can be harnessed to draw a preliminary picture of the global distribution patterns of palpigrades. Thus, we offer a jumping‐off point for future studies on the macroecology and conservation of poorly known organisms.