bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety profile and clinical outcome of adjuvant radiation therapy and intermediate-dose interferon in comparison with intermediate-dose interferon alone in patients with melanoma metastases in regional lymph nodes and unfavorable prognostic factors
Authors: Kukushkina M. , Korovin S. , Diedkov S. , Ostafiichuk V. , Diedkov A. 
Published: October 2021

Summary. Aim: To assess the safety profile and efficacy of adjuvant radiation therapy and intermediate-dose interferon in comparison with intermediate-dose interferon alone in patients with synchronous and metachronous skin melanoma metastases in regional lymph nodes with unfavorable prognostic factors. Materials and Methods: 96 patients with synchronous and metachronous skin melanoma metastases in regional lymph nodes (stage III according to American Joint Committee on Cancer) and unfavorable prognostic factors were randomized in 2 groups: one of them (n = 45) received regional radiation therapy 50–55 Gy and intermediate dose of α2b-interferon (RT + IFN) in adjuvant setting and another one (n = 51) intermediate dose of α2b-interferon alone (IFN). Results: The most common adverse events in both groups were pyrexia and fatigue but grades 3–4 were observed more frequently in the RT + IFN group than in the IFN group (24.4 and 42.2% vs 11.8 and 27.5% respectively). 3-year recurrence-free survival was 78.5% in the RT + IFN group and 73.8% in the IFN group (p = 0.72), 3-year progression-free survival was 63.2% in the RT + IFN group comparing with 57.2% in the IFN group (p = 0.59) and 3-year overall survival was 77.1% and 66.7%, respectively (p = 0.29). Median of recurrence-free, progression-free and overall survival was not reached in any group. Conclusions: Radiation therapy and intermediate-dose interferon in adjuvant setting tends to improve recurrence-free, progression-free and overall survival comparing with intermediate-dose interferon alone in patients with synchronous and metachronous skin melanoma metastases in regional lymph nodes and unfavorable prognostic factors but it needs further investigation in larger groups of patients.
Gangguan Koagulasi Pada Pasien Covid-19
Authors: HARJIANTI TUTIK 
Published: October 2021

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) merupakan famili dari coronavirus, sudah dua kali menyababkan kejadian luar biasa yaitu di tahun 2003 dengan SARS (Severe Acute Respiratory Syndrome) dan tahun 2012 dengan penyakit MERS (Middle East Respiratory Syndrome). Pada tahun 2019 SARS-CoV-2 telah menyebabkan pandemi global kembali. Pertama kali diidentifikasi di Wuhan, Cina. Dan telah menyebar ke seluruh negara dengan jumlah kasus yang terus meningkat secara eksponensial diseluruh dunia. Pada Maret 2020 oleh WHO dinyatakan pandemic. (Covid-19), menyebabkan pneumonia dan beberapa kondisi dapat terjadi Acute Respiratory Distress Syndrome (ARDS) serta beberapa manifestasi ekstra paru, seperti kardiovaskular, saluran cerna, ginjal ,hematologi, sekuele akibat trombosis dan progresifitas disfungsi organ.1
Prognosis pada pasien Covid-19 salah satu tanda ,gejalanya adalah terjadinya gangguan koagulasi, yang ditandai dengan meningkatnya nilai D dimer sebagai tanda awal kondisi thrombosis dan salah satunya dapat bermanifestasi sebagai Venous Thromboembolism (VTE). Pada pasien dengan Covid-19, kondisi koagulopati adalah salah satu kunci dan tanda persisten yang terkait dengan outcome yang buruk.1,2
Kegiatan Pengabdian Jum’at Berkah: Swab Massal, Penyuluhan Kesehatan, dan Pembagian Al-Qur’an
Authors: Syamsu Rachmat Faisal , Arfah Arni Isnaini , AM Nasrudin , Royani Ida , Rijal Syamsu , Kusumardhani Sri Irmandha , Bima Irmayanti Haidir , Murfat Zulfitriani , Murfat Zulfitriani , Surdam Zulfiyah , Syahruddin Febie Irsandi , Dahliah Dahliah , Rahmawati Rahmawati , R.Akib Marliyanti , Natasha Ratih , Masdipa A , Pangnguriseng Utomo Andi 
Published: October 2021

Kegiatan yang berorientasi kepada masyarakat merupakan merupakan salah satu tridarma perguruan dibidang pengabdian. Dukungan dari berbagai pihak yang mengajak kerjasama dengan Fakultas Kedokteran UMI untuk mengadakan kegiatan bakti sosial dalam rangka Milad UMI ke 67 tahun dan Milad Fakultas Kedokteran ke 29 tahun. Bukan hanya organisasi kesehatan saja yang dapat mengadakan kegiatan posko kesehatan, namun adanya kerjasama dengan pihak-pihak luar dari kesehatan mampu dijadikan contoh yang baik dalam meningkatkan kesehatan masyarakat apalagi dimasa pandemi sekarang ini. Dosen-dosen FK UMI tergerak hati unntuk melakukan kegiatan pengabdian yang dirangkaikan oleh Jum’at Berkah. Dimana kegiatan ini untuk para santriPesantren tahfizhul Qur’an Al-Adawiyah. Oleh karena itu, kami dari Fakultas Kedokteran UMI bekerjasama dengan LPkM UMI, dan RS Ibnu Sina menyalurkan bantuan tenaga dan materi berupa Swabb Masal, Penyuluhan Kesehatan, dan Pembagian Al-Qur’an.
Kegiatan ini diagendakan pada tanggal 18 Juni 2021 yang bertempatkan di Mesjid Al-Adawiyah, jl. Racing Centre komp. UMI, Makassar, Sulawesi Selatan. Tim Medis melakukan kegiatan pegabdian Jum’at Berkah berupa swabb masal, penyuluhan kesehatan, dan pembagian Al-Qur’an untuk para santri pesantren Al-Adawiyah. Kegiatan ini diikuti sebanyak 20 anak santri dan para undangan ikut pula mengikuti kegiatan penyuluhan kesehatan mengenai mata dan hidup bersih selama covid 19.
Shoe-Lace Technique Hasten Delayed Primary Closure In Fasciotomy Wound For Forearm Compartment Syndrome
Authors: Bain Mohd Asha'ari , Md Shariff Mohd Shaffid , Mohamad Nazarallah Mohamad Hilmi , Azman Nur Dina , Norazmi Abu 'Ubaidah Amir 
Published: October 2021

We report a case of acute compartment syndrome of the forearm in a 51-year-old man with open fracture distal third radius (Gustilo I). Decompressive fasciotomy was performed promptly. Complete progressive closure of the wound without split-thickness skin grafting was achieved using a shoe-lace technique: silastic vessel loop were interlaced held together with skin staplers placed at the edge of the fasciotomy wound and were then tightened daily. Delayed primary closure of the fasciotomy wound was performed after 8 days post fasciotomy with complete opposition of skin edges without tension. Shoelace closure is a good option for atraumatic fasciotomy wound closure with good cosmesis result.
Travel Behavior of Car Travelers with the Presence of Park-and-Ride Facilities and Autonomous Vehicles
Authors: Hamadneh Jamil , Esztergár-Kiss Domokos 
Published: October 2021

Travelers' behavior is predicted based on their individual preferences. People search for alternatives to maximize their benefit from doing activities, such as increasing the activity time by minimizing the travel time. Traffic congestion and the scarcity of parking spaces in the city center motivate the decision-makers to encourage travelers to use the park-and-ride (P&R) system. An evaluation concerning the impact of using the P&R system on the travel behavior of car users is conducted. Some of the existing P&R facilities are incorporated into the daily activity plans of car travelers to produce new daily activity plans (i.e., P&R facility is considered an activity). By using the Multi-Agent Transport Simulation (MATSim) open-source tool, simulations of the daily activity plans including the P&R system and autonomous vehicles (AVs) are conducted. The study examines three scenarios: (1) a simulation of the existing condition, (2) a simulation of the daily activity plans of the travelers with the P&R system, and (3) a simulation of the daily activity plans of the travelers with the P&R system and AVs. The results show that using the P&R system increases the overall travel time compared with the existing conditions, and the use of AVs as a transport mode impacts the existing modal share as follows: 64 % of the car users switch to AVs, while 15 % of the car users switch to public transport. The output of this study might be used by policy-makers in parking pricing and the location of the P&R facilities.
El análisis de riesgos en los centros históricos: estudio de las fortificaciones urbanas del centro histórico de Sevilla
Authors: Ortiz Calderón Rocío , Moreno Falcón Mónica , Becerra Luna Javier , Corona Corrales Samuel , Ortiz Calderón Pilar 
Published: October 2021

Los centros históricos son espacios culturales complejos que albergan gran cantidad y diversidad de bienes patrimoniales, y cuya conservación obliga a disponer de metodologías capaces de evaluar escenarios de riesgo múltiples. Como respuesta a esta situación, los modelos metodológicos desarrollados en los proyectos RIVUPH y ART-RISK, ofrecen herramientas de análisis multi-riesgo en entornos urbanos mediante el uso de Sistemas de Información Geográfica, Inteligencia Artificial, y/o modelos de consulta a expertos tipo DELPHI.
Este estudio explora la aplicabilidad del análisis multi-riesgo en la evaluación de las peligrosidades y vulnerabilidad que presentan la muralla urbana y los cercos exteriores del Alcázar ubicados en el Centro Histórico de Sevilla. Para su análisis las fortificaciones han sido divididas en tramos y unidades de análisis, se han evaluado las amenazas e índices de vulnerabilidad, y se ha normalizado e interrelacionado la información en un Sistema de Información Geográfica que permite conocer los riesgos según un modelo multi-escenario.
El modelo aplicado permite realizar un análisis descriptivo de las variables de peligrosidad que afectan a las fortificaciones de Sevilla y compararlo con la vulnerabilidad de los tramos analizados. En los muros de Tapia estudiados en Sevilla, la ascensión de agua subterránea por capilaridad es la principal amenaza y las patologías por humedades afectan al 90% de las unidades analizadas. El modelo utilizado es aplicable a otras ciudades y tipologías constructivas, permite realizar una conservación preventiva sostenible y monitorizar los efectos de las amenazas en función de cómo varía la vulnerabilidad con el paso de los años.
Performance of Lactate and CO2-Derived Parameters in Predicting Major Postoperative Complications After Cardiac Surgery With Cardiopulmonary Bypass: Protocol of a Diagnostic Accuracy Study
Authors: Zhou Xiao-Fen , Yu Rong-Guo , Chen Qian , Xue Yi-Min , Chen Han 
Published: October 2021

Background:CO2-derived parameters are increasingly used to identify either low-flow status or anaerobic metabolism in shock resuscitation. However, the performance of CO2-derived parameters in cardiac surgical patients is poorly understood. This study aims to compare the performance of lactate and CO2-derived parameters in predicting major postoperative complications after cardiac surgery with cardiopulmonary bypass.Methods:This is a prospective, single-center, diagnostic accuracy study. All patients who receive elective cardiac surgery involving cardiopulmonary bypass will be screened for study eligibility. Blood samples will be taken for the calculation of CO2-derived parameters, including the venous-arterial difference in CO2partial pressure (PCO2gap), venous-arterial difference in CO2content to arterial-venous O2content ratio (Cv-aCO2/Ca-vO2), and venous-arterial difference in CO2partial pressure to arterial-venous O2content ratio (Pv-aCO2/Ca-vO2) at ICU admission, and 3, 6, and 12 h later. Baseline, perioperative data will be collected daily for 7 days; patients will be followed up for 28 days to collect outcome data. The primary endpoint is the occurrence of major postoperative complications. Receiver-operating characteristics (ROC) curve analysis will be carried out to assess the predictive performance of lactate and CO2-derived parameters. The performance of the ROC curves will be compared.Discussion:The performance of lactate and CO2-derived parameters in predicting major postoperative complications will be investigated in the non-sepsis population, which has not been extensively investigated. Our study will compare the two surrogates of respiratory quotient directly, which is an important strength.Trial Registration:ChiCTR, ChiCTR2000029365. Registered January 26th, 2020,http://www.chictr.org.cn/showproj.aspx?proj=48744.
Effect of Digoxin Therapy on Mortality in Patients With Atrial Fibrillation: An Updated Meta-Analysis
Authors: Wang Xiaoxu , Luo Yi , Xu Dan , Zhao Kun 
Published: October 2021

Background: Whether digoxin is associated with increased mortality in atrial fibrillation (AF) remains controversial. We aimed to assess the risk of mortality and clinical effects of digoxin use in patients with AF.Methods: PubMed, Embase, and the Cochrane library were systematically searched to identify eligible studies comparing all-cause mortality of patients with AF taking digoxin with those not taking digoxin, and the length of follow-up was at least 6 months. Hazard ratios (HRs) with 95% confidence intervals (CIs) were extracted and pooled.Results: A total of 29 studies with 621,478 patients were included. Digoxin use was associated with an increased risk of all-cause mortality in all patients with AF (HR 1.17, 95% CI 1.13–1.22, P &lt; 0.001), especially in patients without HF (HR 1.28, 95% CI 1.11–1.47, P &lt; 0.001). There was no significant association between digoxin and mortality in patients with AF and HF (HR 1.06, 95% CI 0.99–1.14, P = 0.110). In all patients with AF, regardless of concomitant HF, digoxin use was associated with an increased risk of sudden cardiac death (SCD) (HR 1.40, 95% CI 1.23–1.60, P &lt; 0.001) and cardiovascular (CV) mortality (HR 1.27, 95% CI 1.08–1.50, P &lt; 0.001), and digoxin use had no significant association with all-cause hospitalization (HR 1.13, 95% CI 0.92–1.39, P = 0.230).Conclusion: We conclude that digoxin use is associated with an increased risk of all-cause mortality, CV mortality, and SCD, and it does not reduce readmission for AF, regardless of concomitant HF. Digoxin may have a neutral effect on all-cause mortality in patients with AF with concomitant HF.Systematic Review Registration:https://www.crd.york.ac.ukPROSPERO.
Debris Emergence Elevations and Glacier Change
Authors: Shea Joseph M. , Kraaijenbrink Philip D. A. , Immerzeel Walter W. , Brun Fanny 
Published: October 2021

Debris-covered glaciers represent potentially significant stores of freshwater in river basins throughout High Mountain Asia (HMA). Direct glacier mass balance measurements are extremely difficult to maintain on debris-covered glaciers, and optical remote sensing techniques to evaluate annual equilibrium line altitudes (ELAs) do not work in regions with summer-accumulation type glaciers. Surface elevation and glacier velocity change have been calculated previously for debris-covered glaciers across the region, but the response of debris cover itself to climate change remains an open question. In this research we propose a new metric, i.e. the debris emergence elevation (ZDE), which can be calculated from a combination of optical and thermal imagery and digital elevation data. We quantify ZDE for 975 debris-covered glaciers in HMA over three compositing periods (1985–1999, 2000–2010, and 2013–2017) and compare ZDE against median glacier elevations, modelled ELAs, and observed rates of both mass change and glacier velocity change. Calculated values of ZDE for individual glaciers are broadly similar to both median glacier elevations and modelled ELAs, but slightly lower than both. Across the HMA region, the average value of ZDE increased by 70 +/− 126 m over the study period, or 2.7 +/− 4.1 m/yr. Increases in ZDE correspond with negative mass balance rates and decreases in glacier velocity, while glaciers and regions that show mass gains and increases in glacier velocity experienced decreases in ZDE. Regional patterns of ZDE, glacier mass balance, and glacier velocities are strongly correlated, which indicates continued overall increases in ZDEE and expansion of debris-covered areas as glaciers continue to lose mass. Our results suggest that ZDE is a useful metric to examine regional debris-covered glacier changes over decadal time scales, and could potentially be used to reconstruct relative mass and ELA changes on debris-covered glaciers using historical imagery or reconstructed debris cover extents.
Rare Co-Occurrence of Visual Snow in a Female Carrier With RPGRORF15-Associated Retinal Disorder
Authors: Tuekprakhon Aekkachai , Pawestri Aulia Rahmi , Suvannaboon Ragkit , Thongyou Ketwarin , Trinavarat Adisak , Atchaneeyasakul La-Ongsri 
Published: October 2021

X-linked retinitis pigmentosa (XLRP), a rare form of retinitis pigmentosa (RP), is predominantly caused by mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene. Affected males often present with severe phenotypes and early disease onset. In contrast, female carriers are usually asymptomatic or show stationary phenotypes. Herein, we reported an 8-year-old female carrier, a daughter of a confirmed RP father with RPGR mutation, with an early onset of progressive cone-rod pattern retinal dystrophy. Additionally, the carrier experienced visual snow-like symptom as long as she recalled. Ophthalmological examination showed the reduction of visual acuity and attenuation of photoreceptor functions since the age of 5 years. Further analysis revealed a heterozygous pathogenic variant of the RPGR gene and a random X-inactivation pattern. Although she harboured an identical RPGR variant as the father, there were phenotypic intrafamilial variations. The information on the variety of genotypic and phenotypic presentations in XLRP carriers is essential for further diagnosis, management, and monitoring of these cases, including the design of future gene therapy trials.
Characterization of Exosome-Related Gene Risk Model to Evaluate the Tumor Immune Microenvironment and Predict Prognosis in Triple-Negative Breast Cancer
Authors: Qiu Pengjun , Guo Qiaonan , Yao Qingzhi , Chen Jianpeng , Lin Jianqing 
Published: October 2021

BackgroundAs a kind of small membrane vesicles, exosomes are secreted by most cell types from multivesicular endosomes, including tumor cells. The relationship between exosomes and immune response plays a vital role in the occurrence and development of tumors. Nevertheless, the interaction between exosomes and the microenvironment of tumors remains unclear. Therefore, we set out to study the influence of exosomes on the triple-negative breast cancer (TNBC) microenvironment.MethodOne hundred twenty-one exosome-related genes were downloaded from ExoBCD database, and IVL, CXCL13, and AP2S1 were final selected because of the association with TNBC prognosis. Based on the sum of the expression levels of these three genes, provided by The Cancer Genome Atlas (TCGA), and the regression coefficients, an exosome risk score model was established. With the median risk score value, the patients in the two databases were divided into high- and low-risk groups. R clusterProfiler package was employed to compare the different enrichment ways between the two groups. The ESTIMATE and CIBERSORT methods were employed to analyze ESTIMATE Score and immune cell infiltration. Finally, the correlation between the immune checkpoint-related gene expression levels and exosome-related risk was analyzed. The relationship between selected gene expression and drug sensitivity was also detected.ResultsDifferent risk groups exhibited distinct result of TNBC prognosis, with a higher survival rate in the low-risk group than in the high-risk group. The two groups were enriched by immune response and biological process pathways. A better overall survival (OS) was demonstrated in patients with high scores of immune and ESTIMATE rather than ones with low scores. Subsequently, we found that CD4+-activated memory T cells and M1 macrophages were both upregulated in the low-risk group, whereas M2 macrophages and activated mast cell were downregulated in the low-risk group in patients from the TCGA and GEO databases, respectively. Eventually, four genes previously proposed to be targets of immune checkpoint inhibitors were evaluated, resulting in the expression levels of CD274, CTLA4, LAG3, and TIM3 being higher in the low-risk group than high-risk group.ConclusionThe results of our study suggest that exosome-related risk model was related to the prognosis and ratio of immune cell infiltration in patients with TNBC. This discovery may make contributions to improve immunotherapy for TNBC.
Case Report: Extracorporeal Membrane Oxgenation for Rapidly Progressive Interstitial Lung Disease Associated With Clinically Amyopathic Dermatomyositis in a Post-partum Woman
Authors: Gu Qiao , Diao MengYuan , Hu Wei , Huang Man , Zhu Ying 
Published: October 2021

Background: Clinically amyopathic dermatomyositis (CADM) presented with rapid progressive interstitial lung disease (RP-ILD) is rare. Here, we present a case of a post-partum female with CADM complicated by severe RP-ILD managed with venovenous extracorporeal membrane oxygenation (V-V ECMO).Case Summary: A 36-year-old woman was referred to a local hospital with cough and fever. She had a history of facial erythema and cough since an induction of labor for a stillborn fetus 2 months ago. Her status developed into RP-ILD with mediastinal emphysema and subcutaneous emphysema after admission, and V-V ECMO was initiated. After several failed attempts to wean the patient from ECMO, a decision was made to place the patient on the lung transplant waitlist. She underwent a double lung transplant on ECMO day 31 and received tacrolimus as an immunosuppressive regimen. The patient presented with positive anti-MDA5 and anti-Ro-52 antibodies and a high ferritin level, all of which indicated the presence of clinically amyopathic dermatomyositis (CADM). The patient was weaned from ECMO at 3 days after transplantation, but the patient's state of consciousness deteriorated, and head CT was considered for posterior reversible encephalopathy syndrome (PRES). After the temporary cessation of calcineurin inhibitors and a dosage reduction, the patient's state of consciousness returned to normal. Because of another disturbance of consciousness, the patient declined further treatment and was discharged 14 days after transplantation.Conclusion: Early recognition of CADM can effectively improve patients' prognosis. ECMO should be considered as a supportive therapy in patients in acute respiratory failure secondary to RP-ILD.