bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Correlates of Cancer-related Fatigue in Breast Cancer Survivors
Authors: Bustos Alejandro Álvarez , Pedro Cristina G. de , Elías María Romero , Ramos Javier , Osorio Pablo , Cantos Blanca , Maximiano Constanza , Méndez Miriam , Luces Carmen Fiuza , Otero Marta Méndez , Martín Silvia , Cebolla Héctor , Casado Ana Ruiz 
Published: February 2021

Abstract
Purpose To identify potential correlates of CRF after curative breast cancer (BC) treatment. The hypothesis was that fatigue would be more severe among women treated with cardiotoxic drugs, with poor physical condition and those who exercised less.Methods Prospective observational cross-sectional design. Fatigue was evaluated through Perform Questionnaire (multi-item, multi-dimensional). Patient-reported assessments and objective information regarding clinical data, physical activity (PA) and physical condition were analysed as potential correlates of CRF.Results 180 women who remained free of disease were recruited. Prevalence of fatigue interfering with quality of life was 43%. Weight, BMI, treatment with trastuzumab and time spent walking one mile were positively associated with fatigue. Age, time from diagnosis, self-reported walking time, basal and recovery heart rate were negatively associated. Previous chemo, radio or hormonal therapy, objectively assessed weekly PA, cardio-respiratory condition, muscular strength and adherence to Mediterranean diet were not associated with CRF. However, an interesting unexpected negative association with nut intake was found.Conclusions CRF is a prevalent problem after BC treatment. Objectively assessed PA, cardiorespiratory fitness and muscular strength did not predict CRF. The association of CRF with trastuzumab and low intake of nuts should be confirmed in further studies. A deeper insight in heart rate variability is warranted. Future research should include longitudinal studies and determination of biomarkers. Implications for Cancer Survivors BC survivors, especially younger and overweight women, should be informed about fatigue as a potential persistent symptom through all stages of the cancer trajectory and into survivorship. They also should be routinely screened for CRF.
Molecular Mechanism of Methyl-Dependent and Spatial-Specific DNA Recognition of c-Jun Homodimere
Authors: Bie Lihua , Fei Jun-wen , Gao Jun 
Published: February 2021

Abstract
DNA methylation is important in regulation of gene expression and normal development because it alters the interplay between protein and DNA. Experiments have shown that a single 5-methylcytosine at different CpG sites (mCpG) might have different effects on specific recognition, but the atomistic origin and dynamic details are largely unclear. In this work, we investigated the mechanism of monomethylation at different CpG sites in the cognate motif and the cooperativity of full methylation. By constructing four models of c-Jun/Jun protein binding to the 5’-XGAGTCA -3’(X represents C or methylated C) motif, we characterized the dynamics of the contact interface using the all-atom molecular dynamics method. Free energy analysis of MM/GBSA suggests that regardless of whether the C12pG13 site of the bottom strand is methylated, the effects from mC25pG26 of the top strand are dominant and can moderately enhance the binding by ~ 31kcal/mol, whereas mC12pG13 showed a relatively small contribution, in agreement with the experimental data. Remarkably, we found that this spatial-specific influence was induced by different regulatory rules. The influence of the mC25pG26 site is mainly mediated by steric hindrance. The additional methyl group leads to the conformational changes in nearby residues and triggers an obvious structural bending in the protein, which results in the formation of a new T-ASN-C triad that enhances the specific recognition of TCA half-sites. The substitution of the methyl group at the C12pG13 site of the bottom strand breaks the original H-bonds directly. Such changes in electrostatic interactions also lead to the remote allosteric effects of protein by multifaceted interactions but have negligible contributions to binding. Although these two influence modes are different, they can both fine-tune the local environment, which might produce remote allosteric effects through protein-protein interactions. Further analysis reveals that the discrepancies in these two modes are primarily due to their location. Moreover, when both sites are methylated, the major determinant of binding specificity depends on the context and the location of the methylation site, which is the result of crosstalk and cooperativity.
Investigating the Resilience of Nurses During the COVID-19 Pandemic A Cross-Sectional Survey from Lebanon
Authors: Alameddine Mohamad , Bou-Karroum Karen , Ghalayini Wahida , Abiad Firas 
Published: February 2021

Abstract
Background: The COVID-19 pandemic placed frontline nurses under great pressure, influencing their physical and psychological wellbeing. Resilience has been recognized as a protective factor in times of crisis. Purpose: Investigate the degree of resilience, and associated factors, of nurses practicing at a major public hospital and COVID-19 main referral center in Lebanon. Methods: A cross-sectional online survey investigating nurses’ demographic characteristics, job satisfaction, turnover intentions, exposure to violence, and resilience levels. Multiple linear regression was used to determine factors related to resilience. Findings: The study had a response rate of 86% and a mean resilience score of 66.91 (SD = 13.34). Nurses’ resilience is positively associated with job satisfaction and male gender and negatively associated with intention to quit and exposure to violence. Discussion: Enhancing the resilience of nurses improves their job satisfaction and retention at time of crisis, and would help support the effectiveness and efficiency of care services.
Coagulation Status in Women With Missed Abortion
Authors: Yang Shuo , Chen Dandan , Wang Junxiong , Qiao Rui , Cui Liyan 
Published: February 2021

Abstract
Background: Missed abortion is a special type of spontaneous miscarriage, as well as a complex and multifactorial reproductive health problem that affects people all over the world. The purpose of this study was to assess the status of coagulation function in a large series of reproductive-age women diagnosed as missed abortion. Likewise, we want to explore the association between coagulation and missed abortions, in order to evaluate whether they could be used as early predictive factors for missed abortions.Methods: A total of 11182 women who suffered from missed abortion from Peking University Third Hospital and 5298 healthy age –matched early pregnancy women were enrolled in our study. Coagulation function test (prothrombin time, activated partial thromboplastin time), fibrinolysis status detection (fibrinogen, D-Dimer), anticoagulation function tests (protein C, protein S and antithrombin III) and lupus anticoagulants (LAC) were examined on an automated coagulation analyzer. In addition, platelet counts were detected by automated hematology analyzer. Platelet aggregation (PAgT) were tested by light transmission aggregometry (LTA). All tests were taken according to standard operating procedures of the instruments.Results: Compared with healthy pregnancy, the level of D-Dimer and platelet count were higher, and the antithrombin III (AT-III) activity was lower(P<0.05). 13.1% patients with missed abortion were positive for LAC, and platelet aggregation was increased in 47.4% patients. There were no significant differences in the levels of PT, aPTT, TT, fibrinogen, protein C and protein S between the patients with missed abortion and healthy pregnancy. Moreover, multivariate logistic regression analysis showed that D-Dimer, dRVVT-R, AT-III and PAgT had significant predictive value for missed abortion.Conclusion: These findings provide evidence of hypercoagulability in patients with missed abortion. Lupus anticoagulant, PAgT and D-Dimer were the strongest predictors of missed abortion. These data suggest that treatment of the lupus anticoagulant and antiplatelet aggregation could be considered in missed abortion.
Investigation of Ti Doping on the Structural, Optical and Magnetic Properties of ZnO Nanoparticles
Authors: P Raji , Kumar K Balachandra 
Published: February 2021

Abstract
Ti - doped ZnO (TixZn1-xO x= 0.00, 0.05, 0.10, 0.15) nanoparticles have been synthesized through co - precipitation approach. X-ray diffraction (XRD), scanning electron microscopy (SEM), photoluminescence (PL), UV-Visible spectroscopy, and Vibrating Sample Magnetometer (VSM) have been used to characterize the samples. X-Ray Diffraction (XRD) analysis manifested the hexagonal wurtzite structure. The crystallite size decreased from 37 ​nm to 29 ​nm as dopant concentration is increased. Fourier transform infrared analysis showed the absorption bands of ZnO, with few within the intensities. SEM investigation showed the irregular shape and agglomeration of the particles. Ti, Zn, and O composition were determined from EDX analysis and confirmed the purity of the samples.PL spectra showed a near band edge emission and visible emission.Vibrating sample magnetometer (VSM) demonstrated pure and doped samples exhibited ferromagnetism behavior at room temperature.
A Sensitivity Analysis of the Anisotropy of Hydraulic Conductivity to the Seepage, Deformation and Stability of Anti-Dipping Layered Rock Slopes: A Case Study of the Pulang Area in Southwestern China
Authors: Zhang Guangkeng , Lu Guangyin , Xia Chengzhi , Wu Lianrong , Xu Zongming , Bai Ying , Li Jialu 
Published: February 2021

Abstract
In this paper, in order to study the influencing effects of anisotropy ratios and anisotropy directions on the seepage, deformations and stability of the anti-dipping layered rock slopes, Geo-studio software was used in this study to carry out this test based on the unsaturated seepage, fluid-solid coupling, and stability theory numerical analysis of carbonaceous slate slopes in Pulang area. The results showed that the maximum surface water content of the layered rock slopes gradually decreased with increases of the water conductivity anisotropy ratio and decreases in the anisotropy angle of the anti-dipping layered rock slopes. In addition, the rainfall infiltration depths in the middle sections of the slopes were observed to be the most affected by the anisotropy ratio and dip angles of the rock formations. Meanwhile, the bottom sections of slopes were the least affected by the anisotropy ratio and the dip angles of the rock formations. In regard to the anti-dipping rock slopes, it was found that the anisotropy ratio and rock layer dip angles should be considered in the deformation and stability analyses. When the seepage of an anti-dipping layered slope was considered to be isotropic, the safety factors often were overestimated. As the anisotropy ratio decreases and the anti-tilt angles of the layered planes increases, the safety factors of the slopes will gradually decrease. This study provided a feasible scheme for evaluating the seepage, deformations and stability of the anti-dipping layered rock slopes in southwest China’s Pulang area.
WITHDRAWN: Identification of Chatter Vibrations and Active Vibration Control by Using Sliding Mode Controller on Dry Turning of Ti6al4v
Authors: GUVENC Mehmet Ali , BILGIC Hasan Huseyin , MISTIKOĞLU Selçuk 
Published: February 2021

Abstract
In recent years, with the development of sensor technologies, communication platforms, cyber physical systems, storage technologies, internet applications and controller infrastructures, the way has been opened to produce competitive products with high quality and low cost. In turning, which is one of the important processes of machining, chatter vibrations are among the biggest problems affecting product quality, productivity and cost. There are many techniques proposed to reduce chatter vibrations for which the exact cause cannot be determined. In this study, an active vibration control based on Sliding Mode Control (SMC) has been implemented in order to reduce and eliminate chatter vibration, which is undesirable for the turning process. In this context, three-axis acceleration data were collected from the cutting tool during the turning of Ti6Al4V. Finite Impulse Response (FIR) filtering, Fast Fourier Transform (FFT) analysis and integral process were carried out in order to use the raw acceleration data collected over the system in control. The system was modeled mathematically and an active control block diagram was created. It was observed that chattering decreased significantly after the application of active vibration control. The surface quality formed by the amplitude of the graph obtained after active control has been compared and verified with the data obtained from the actual manufacturing result.
Hepatic Adenomatosis in Aicardi Syndrome: A Clinical Report and Review of The Literature
Authors: Boninsegna Enrico , Simonini Emilio , Crosara Stefano , Semeraro Antonia , Colopi Stefano 
Published: February 2021

Abstract
Aicardi Syndrome is a rare X-linked dominant genetic disorder characterized by callosal agenesis, generalized seizures, chorioretinal lacunae and vertebral anomalies. Uncommon neoplasms have been previously observed in affected patients. We describe the case of a 19-year-old woman with Aicardi Syndrome developing multiple giant mass lesions in the liver. Histopathology revealed hepatic adenomas.
Design and Fabrication of High Performance Photoanode of Fe2(MoO4)3/RGO Hybrid Composites For Triiodide Reduction in Dye-Sensitized Solar Cells
Authors: Thulasi Selvam , Arunprasad Veeranan , KARTHIK SIVA , Elatharasan G. , Senthil P. 
Published: February 2021

Abstract
Discovery of electrode materials with superior light harvesting performance with high conductivity nature have become more and more urgent for the field of photovoltaics and portable electronic devices. Here in, synthesis of Fe2(MoO4)3/reduced graphene oxide (RGO) nanocomposite was prepared by simple hydrothermal approach and used as high efficient dye sensitized solar cells (DSSCs). The decoration of RGO into the Fe2(MoO4)3 was proved by various physic-chemical studies such as XRD, SEM, TEM, Raman, UV, PL and BET analysis. Due to the synergic effect between the Fe2(MoO4)3 and RGO the light absorption property is significantly improved as well the high surface area (112.5 m2/g) and pore size (38.7 nm) was achieved than compared with bare Fe2(MoO4)3 (88.5 m2/g and 17.8 nm). The Fe2(MoO4)3/RGO hybrid photoanode establish to display an outstanding catalytic activity toward the reduction of triiodide to iodide in a dye-sensitized solar cell (DSSC) and can provide a solar cell efficiency of 9.65%, which is superior to a Pt-based DSSC (6.17%). The better electro-catalytic ability of Fe2(MoO4)3/RGO electrode is obtained by a synergistic effect that resulted in the high specific surface area and intrinsic reactivity of the photocathode materials.
Causes and Effects of Tree Removal in University of Ibadan Campus
Authors: Agbaogun Sulaimon Olaniyan , Jimoh Saka Oladunni 
Published: February 2021

Abstract
Trees on the university of Ibadan campus environment are positioned in a remarkable and notable manner; however, they may also present potential hazards to the infrastructure and humans they coexist with. The numerous benefits of trees can be negated due to poor tree health and anthropogenic activities and as such they may become hazardous. The study aims at evaluating the causes and effects of tree removal on University of Ibadan Campus, Oyo State Nigeria. University of Ibadan was stratified into 4 locations which are: Residential areas, Administrative areas, Parks and Gardens and Academic Areas. 323 trees comprising of 38 species were identified and the locations where they were removed was identified also. Also, 200 respondents were sampled to assess the perceived effects of removal of campus trees and some members of campus biodiversity management committee were interviewed to ascertain the reasons behind tree removal on campus. With the aid of data form, oral interviews, site assessments, G.P.S and structured questionnaires, the trees removed in the last ten years, the reasons for their removal and perceived effects of tree removal on campus were ascertained.The results revealed that the most trees removed on campus were Delonix regia 22.3% and Albizia glaberima 15.8% while the least removed were Anarcadium occidentale, Bridelia micrantha, Cocos nucifera, Ficus mucuso, Morinda Lucinda, Pinus carribea, Tabebuia rosea and Terminalia superba with 0.3% each.Residential areas had the highest number of tree removal on campus while the parks and gardens and administrative areas had the least. Trees removed were because of so many reasons in which old age, threat to buildings, tree defects and wind throwing are more prominent.In conclusion, the study revealed that the tree species removed had no specific relationship with the reasons for their removal but the reasons for removal of the trees had an association with the locations where they were removed. Also, it revealed that almost all the trees removed on campus was because they were or may later have some negative impacts on lives, environment and properties and mostly to forestall dangers. Since there will always be some common interactions between the environment, lives, properties and trees on campus, the study recommends effective management of campus trees and removal in cases where necessary and also replacement of removed trees especially because of root rots, insect infestation, dead trees and old age should be encouraged.
Dipeptidyl Peptidase-4 modulates Long-chain Acyl-CoA synthetase 4 to Promote Lipid Peroxidation and Regulate Ferroptosis in Pancreatic Cancer
Authors: Zhou Xiang , Wang Weiming , Zhang Baofu , Chen Xiaohu , Zheng Jiuyi , Guo Pengyi , Zhao Jungang , Bao Wenming , Chen Guorong , Shan Yunfeng , Yu Zhengping , Wang Yi , Chen Gang 
Published: February 2021

Abstract
Background: The global mortality rate of pancreatic ductal adenocarcinoma (PDAC) is one of the highest among all cancers, and curative chemotherapeutics are essentially nonexistent. Dipeptidyl peptidase-4 (DPP4) plays a critical role in ferroptosis, a recently discovered regulated mechanism of necrotic cell death that has an important function in colorectal cancer. However, whether DPP4 contributes to ferroptosis in pancreatic cancer has remained unknown. Methods: DPP4 expression status was evaluated in PDAC tissues using tissue chip immunohistochemistry. The effects of DPP4 re-expression on cell proliferation, the cell cycle and energy metabolism were determined. DPP4-related cancer pathways was identiﬁed by RNA-seq analyses. The clinical impact of DPP4 in driving ferroptosis and attenuating gemcitabine sensitivity was assessed in DPP4 knockout (KD) mice orthotopic xenograft models of PDAC.Results: We found that DPP4 is expressed at low levels in PDAC, and that it significantly inhibited cell proliferation by causing G1–S cell cycle arrest, inhibiting energy metabolism, and promoting erastin-induced ferroptosis in vitro; it also suppressed tumor growth in transgenic orthotopic xenograft mouse models (P < 0.001). Importantly, the sensitivity of cells overexpressing DPP4 to gemcitabine and ferroptosis was respectively decreased and increased. Mechanistically, DPP4 facilitated ferroptosis by binding long-chain acyl-CoA synthetase 4 (ACSL4), and interaction with DPP4 stabilized ACSL4 by inhibiting its ubiquitin-mediated degradation and subsequent lipid peroxidation. Conclusions: These findings identify a novel role of DPP4 in ferroptosis and suggest a potential therapeutic strategy with which to overcome gemcitabine resistance in PDAC.
The Association&nbsp;between&nbsp;Serum Potassium Level and 30-day&nbsp;Mortality for Patients with&nbsp;Cardiac Arrhythmias&nbsp;in the Emergency Department: Secondary Analysis of&nbsp;a Cohort Study
Authors: Chang Le , Chen Xinglin , Lian Cheng 
Published: February 2021

Abstract
Background: Clinical evidence shows that mortality in relation to the potassium ranges was U-shaped in patients with hypertension, heart failure and cardiovascular disease. However, evidence is lacking for patients with cardiac arrhythmias in the emergency department. Present study aimed to clear the relationship between serum potassium level and mortality for patients with cardiac arrhythmias in the emergency department.Methods: Using data from a retrospective cohort study, we identified 7532 visits involving 3882 patients with cardiac arrhythmias referred for any reason to the emergency department (ED) between January 1, 2010, and December 31, 2015. All-cause mortality within 30-days after the date of visit to the ED. We estimated the risk of mortality using multivariable logistic-regression model.Results: There were 448 deaths (5.9%). The probability of mortality rose rapidly when potassium higher than the turning point (potassium ≥ 4.3 mmol/L) with a adjusted OR of 1.13 (95% CI:1.09, 1.16) for every 0.1 mmol/L increment of potassium. Moreover, the probability of mortality decreased when potassium lower than the turning point (potassium < 4.3 mmol/L) with a adjusted OR of 0.95 (95% CI:0.91, 0.98). Conclusions: Higher serum potassium, even at a low level, was associated with a higher risk of 30-day mortality for patients with cardiac arrhythmias in the emergency department. The probability of mortality rose rapidly when potassium higher than the turning point (may at 4.3 mmol/L).
The Effects of Sub-lethal dose of Insecticides on Honeybee Behavior and Transcriptome
Authors: Zhang Zuyun , Li Zhen , Huang Qiang , Zeng Zhijiang 
Published: February 2021

Abstract
Exposure to insecticides is the main cause of honeybee (Apis mellifera) population decline. At sub-lethal doses, these chemicals have been shown to negatively affect honeybee physiological development and behavior. Previously, we found the insecticide imidacloprid and deltamethrin significant reduced honeybee dancing and foraging efficiency. As a follow up, we performed a deep RNA-seq analysis to reveal the gene regulatory mechanisms underlying the altered foraging behavior. Genes involved in detoxification were up-regulated in both imidacloprid and deltamethrin treatment groups. Gene members in immune pathways, odorant receptors and major royal jelly protein families showed significant up or down regulation in treatment groups compared with controls. This fluctuating gene expression profile reflects that multifaceted aspects of honeybee physiology were affected by the two insecticides, leading to inaccurate communication and impaired learning and memory. Our findings reveal candidate molecular mechanisms under impaired dance performance in honeybees exposed to insecticides.