bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Long-Term Outcome of Cyberknife Radiotherapy for Central Skull Base Meningiomas: A Single-Center Experience
Authors: Hong Sukwoo , Sato Kengo , Kagawa Kenji , Ichi Shunsuke 
Published: February 2021

Abstract
Few reports exist demonstrating the effects of CyberKnife radiotherapy (CKRT) on the central skull base meningiomas (CSMs). Retrospective analysis of 113 patients were performed. The median age was 62 (IQR 50 – 72) years old, and 78 patients (69%) were female. Upfront CKRT was performed in 41 (36%), where 17 (15%) patients were asymptomatic. The other CKRT was for postoperative adjuvant therapy in 32 (28%), and for the recurrent or relapsed tumors in 40 (35%) patients. Previous operation was done in 74 patients (66%). Among the available pathology in 46 patients, 37 (80%) were WHO grade I, 8 (17%) were grade II, and 1 (2%) were grade III. The median prescribed dose covered 95% of the planning target volume was 2500 (IQR 2100 – 2500) cGy and the median target volume was 9.5 (IQR 3.9 – 16.9) cm3. The median PFS was 48 (IQR 23 – 73) months and 84% and 78% were free of tumor progression at five, and 10 years respectively. The median follow-up was 49 (IQR 28 – 83) months. PFS was better in grade I than grade II (p = 0.02). No other baseline factors including the history of previous operation was associated with PD or PFS. Adverse events of radiation therapy were radiation- induced optic neuropathy (0.9%), and cerebral edema (4.4%). Asymptomatic cavernous carotid stenosis was found in three (2.7%), five (4.4%) underwent ventriculoperitoneal shunt placement for normal pressure hydrocephalus, and five (4.4%) died. CKRT is useful for the management of CSMs with low rate of adverse events.
Chromosomal Characteristics and Prognostic Analysis of Secondary Acute Myeloid Leukemia
Authors: Song Mingzhu , Zhang Tun , Yang Dongdong , Xiao Hao , Wang Huiping , Zhai Zhimin , Ye Qianling 
Published: February 2021

Abstract
BackgroundSecondary Acute Myeloid Leukemia (S-AML) patients generally have a poor prognosis, and the chromosomal karyotype of S-AML have been rarely reported in the published literature. We aimed to explore the chromosomal karyotype and its clinical significance in patients with S-AML.MethodsClinical characteristics and chromosome karyotypes of 26 patients with S-AML were retrospectively analyzed. The overall survival (OS) was measured from the time of the patients’ transition to AML (which means the time of S-AML diagnosis) .ResultsAmong the 26 S-AML patients, there were 13 males and 13 females, with a median age of 63 years old (range, 20-77 years old). All of them were secondary to a variety of hematologic malignancies or solid tumors, and most of them were secondary to myelodysplastic syndrome (MDS). About 62% of the S-AML patients showed chromosome abnormalities. The level of serum lactate dehydrogenase (LDH) in S-AML patients with abnormal chromosome karyotype was higher than those with normal chromosome karyotype. Apart from the differences in treatment regimens, S-AML patients with chromosomal karyotype abnormalities had shorter OS (P<0.05). Conclusions﻿S-AML patients with abnormal chromosomal karyotype have higher LDH and shorter OS than normal chromosomal karyotype, and the OS of hypodiploidy was much shorter than hyperdiploid.
Examining the Impact of Technical Controls, Accountability and Monitoring towards Cyber Security Compliance in E-government Organisations
Authors: Alqahtani Mohammed , Braun Robin 
Published: February 2021

Abstract
IT infrastructure and systems are made up of technical as well as social systems that work in alliance to ensure that organization's goals and objectives are met. Security controls and measures are developed and used to guard data and information systems of the organization. The breaches of Cyber security are primarily caused by the misuse of information systems and failure to comply with cyber security measures. Cyber security non-compliance is a major concern for organizations. For effective compliance and human acceptance of cyber security technology and complying with cyber practices, it is essential to ascertain, research, and examine the factors which contribute to the compliance and implementation of cyber security. This study has utilized an enhanced UTAUT2 i.e. Unified Theory of Acceptance and Use of Technology 2 model and assessed its relationship with cyber security compliance. Five new formal and informal factors that affect cyber security compliance in organizations are identified and evaluated. The research questions addressed are: how the formal factors of technical measures; accountability; monitoring and evaluation impact employee's behaviour towards cyber security compliance. The study comprises a correlational survey of employees working at e-government organizations in Saudi Arabia. Results indicate that there is a significant role play by technical measures; accountability; monitoring and evaluation, on employee attitudes and behaviour towards cyber security compliance.
Association Mapping and Domestication Analysis to Dissect Genetic Improvement Process of Upland Cotton Yield-Related Traits in China
Authors: Chunping GUO , Zhenyuan PAN , Chunyuan YOU , Xiaofeng ZHOU , Cong HUANG , Chao SHEN , Ruihai ZHAO , Qingyong YANG , Longfu ZHU , Zhongxu LIN , Nie Xinhui 
Published: February 2021

Abstract
BackgroundCotton fiber yield is a complex trait, which can be influenced by multiple agronomic traits. Unravelling the genetic basis of cotton fiber yield related traits contributes to genetic improvement of cotton fiber. ResultsIn this study, 503 upland cotton varieties covering the 4 breeding stages in China were used to for association mapping and domestication analysis of upland cotton yield-related traits in China. 140 quantitative trait loci (QTLs) significantly associated with ten fiber yield related traits were identified, among which, 29 QTLs showed an increasing trend contribution to cotton yield-related traits from BS1 to BS4, and 26 QTLs showed decreased trend effect. 4 favorable alleles of 9 major QTLs (R2≥3) were strongly selected during the breeding stages, and the candidate genes of the 4 strongly selected alleles were predicated according to the gene function annotation and tissue expression data. ConclusionsThe study not only uncovers the genetic basis of 10 cotton yield related traits, but also provides genetic evidence for cotton improvement during the cotton breeding process in China.
Dielectric and Optical Spectroscopy of New Poly-Crystalline Ceramic for device Applications
Authors: Parida Rajani K , Bhattacharjee Sourav , Mohanty Bhagyashree , Nayak Nimai C , Parida Bichitra Nanda 
Published: February 2021

Abstract
The polycrystalline double perovskite Li2GdFeTiO6 was synthesized through solid-state mixed oxide method and its preliminary crystal structure was investigated by XRD technique. The structure of the material was identified to be tetragonal with space group P4bm using POWD and MATCH software. The morphology of the sample was investigated through a scanning electron microscope (SEM) and the average grain size was found 3.82 µm using intercept technique. The investigation of the perovskite phase and various vibrational modes were carried out through FTIR spectroscopic technique. The band gap (Eg = 1.73 eV) and visible light sensitivity of the material were identified by UV-Visible spectroscopic operation carried in the range 200–700 nm. The dielectric and related properties were investigated as a function of frequency and temperature using an impedance analyzer (LCR meter). Room temperature dielectric investigation suggests it may be useful for storage application. The transport activities investigated through conductivity, impedance and modulus technique illustrate the significant influence of grains on transportation of charges.
Response of Fungal Communities to Fire in a Subtropical Peatland
Authors: Tian Jianqing , Wang Hongjun , Vilgalys Rytas , Ho Mengchi , Flanagan Neal , Richardson Curtis J 
Published: February 2021

Abstract
Purpose: Wildfire, an increasing disturbance in peatlands, could dramatically change carbon stocks and reshape plant/microbial communities, with long-lasting effects on peatland functions. Soil fungi are important in controlling the belowground carbon and nutrient cycling in peatlands; however, the impact of altered fire regimes on these fungi is still unclear. Methods: Here we assessed fungal abundance, composition, and diversity across four soil depths (0–5 cm, 6–10 cm, 11–15 cm, 16–20 cm) under low-intensity and high-intensity fire in a subtropical peatland in the southeastern USA. Results: Low-intensity fire significantly increased fungal Shannon diversity and the saprotrophic fungal composition in the 0–5 cm soil layer immediately and then retracted within 2 years. Such hump-shaped pattern, however, were not observed in deeper soils. The dominant fungal class Archaeorhizomycetes declined initially and then returned to pre-low-intensity fires levels at 0–5 cm depths. Time since low-intensity fire was a primary driver of fungal composition in the 0–10 cm soil depth, while geographical distance among sites affected the deeper soils (11–20 cm). The fungal Shannon diversity failed to recover to the unburned state even after 30 years after high-intensity fire, especially in 6–20 cm soil depths. Stratification patterns of the fungal community was diminished by high-intensity fire. Soil properties (either phenolics or carbon) were the primary drivers in shaping fungal community reassembly after high-intensity fire across all soil depths. Conclusion: Collectively, the fungal communities seem to be highly resilient to low-intensity fire, but not to high-intensity fire in our shrub bog peatlands.
Long Term Surgical Outcome for Persistent Pupillary Membranes With Associated Ocular Abnormalities: a Retrospective Case Series Study
Authors: Huang Yu-Te , Lin Hui-Ju 
Published: February 2021

Abstract
Background: Deprivation amblyopia is a great concern in hyperplastic persistent pupillary membranes (PPM) which blocked visual axis. Other ocular abnormality may accompany and further hinder the visual development of the infants.We evaluate the long-term visual prognosis and complications in patients with dense PPM and other associated abnormalities treated with early surgical intervention and timely visual rehabilitation.Methods: Medical records of patients with surgical removal of PPM from 2000-2020 and also receiving visual rehabilitation were retrospectively reviewed. Besides visual axis blocked PPM, patients combined with other amblyopic risk factors or ocular abnormalities were included.Due to preparation for subsequent lens extraction if an underlying cataract was present, the surgical settings including the instruments and wound direction were similar to cataract surgery. All patients were enrolled in a visual rehabilitation program as soon as possible. The results including sex, age, timing of operation, initial and final visual acuity, refractive errors, and complications were recorded.Results: Seven cases of five patients were included in this case series. Mean age at surgery was 42.3 ± 21.1 months (range, 5 to 66 months) and the post-operative follow-up period was 4.9 years (range, 1.2 to 8.2 years).The patient age at time of surgery ranged from 2.5 months to 2.5 years (mean, 14 months). Mean postoperative follow-up was 5.3 years (range, 2.5-8 years). There were no intra-operative and post-operative complications. Final BCVA varied with a mean value of 0.29 logMAR (range, 0 to 1 logMAR). An associated ocular abnormality of ametropia and strabismus led to the best visual prognosis.Conclusions: In patients with PPM, there were no significant complications in any patient using our technique. The surgical settings are easier to handle and more familiar with pediatric surgeons. Besides deprivation with patching, early PPM intervention and timely visual rehabilitation achieve the best visual prognosis in patients associated with risk of ametropic and strabismic amblyopia.Trial registration: This retrospective, interventional case series study was conducted at China Medical University Hospital between April 1, 2000 and April 31, 2020. (IRB number: CMUH109-REC2-069)
Activity based Deubiquitinase profiling reveals OTUB1 from oryza sativa Hydrolyzes Linear Ubiquitin Chains by Bi-modal Activation
Authors: Lu Lining , Wang Jiawei , Mei Ziqing , Wang Feng 
Published: February 2021

Abstract
Met1 type ubiquitination and deubiquitination are involved in the regulation of many fundamental processes such as inflammation and innate immunity, and their interference by pathogens can suppress immune responses in human cells. However, no plant-derived deubiquitinases (DUBs) against Met1 ubiquitin chains have been reported. Using a dehydroalanine (DHA)-bearing Met1 diubiquitin (Met1-diUb) suicide probe, synthesized in one-pot, we identified OTUB1 from Oryza sativa (OsOTUB1) and uncovered its preference for Met1 ubiquitin chains. Also, by resolving the apo structure of OsOTUB1 and its complex with Ub or Met1-diUb, we demonstrated that OsOTUB1 hydrolyses Met1 ubiquitin chains by activation of both the distal and proximal ubiquitin, which is different from OTULIN and expands our mechanistic understanding of the DUB-mediated hydrolysis of Met1 ubiquitin chains. Through large-scale sequence alignment and hydrolysis experiments, two sites in the S1' pocket of the OTUB subfamily (OTUBs) were found to determine the hydrolytic ability of OTUBs against Met1 ubiquitin chains, regardless of species. Furthermore, by analyzing the species distribution of OTUBs capable of hydrolyzing Met1 ubiquitin chains, we found that whereas this activity does not exist in metazoans, it is conserved in green plants (Viridiplantae). This discovery may inform studies of the differentiation between primitive plants and animals.
Heat transfer mode shift to adiabatic thermalization in near-critical carbon dioxide under terrestrial conditions
Authors: Parahovnik Anatoly , Peles Yoav 
Published: February 2021

Abstract
Heat transfer via acoustic waves is referred to as adiabatic thermalization or the piston effect. Until now, adiabatic thermalization was believed to be a secondary effect that mostly occurs under microgravity conditions and is readily overpowered by mixing due to gravitational forces. However, this work revealed that in microsystems, adiabatic thermalization is a dominant heat transfer mechanism. A substantial shift in thermalization modes from vaporization to acoustic waves was observed through critical opalescence temperature measurements of carbon dioxide (CO2). The contribution of the piston’s effect increased from 4.3–77.6% when the reduced pressure increased from 0.86 to 0.99. The findings are used to explain the observed heat transfer enhancement that occurred concurrently with the reduction in the void fraction. Revealing the nature of the piston effect to enhance heat transfer will advance copious technological fields like space exploration, fusion reactors, data centers, electronic devices, and sensing technology.
Functional Capacity Predictors in Breast Cancer Women: a Cross-sectional Study
Authors: Costa Ana João Silva , Rodrigues Margarida , Carneiro Ismael , Vaz Inês Machado , Almeida Miguel P. , Joaquim Ana , Antunes Pedro , Alves Alberto , Viamonte Sofia 
Published: February 2021

Abstract
Purpose: Functional capacity (FC) declining has been poorly evaluated and characterized in women with breast cancer (BC). It is expected that FC declining may have an impact on survival, and also compromise quality of life and independence. This study aimed to evaluate the FC of women with BC and identify predictors of obtained results. Methods: A cross-sectional study including women with BC consecutively referred for a physical medicine and rehabilitation consult between October and December 2019. Glittre-ADL Test (TGlittre), maximal respiratory pressure tests [maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP)] and Modified Fatigue Impact Scale were used in order to assess FC, respiratory muscle strength and fatigue, respectively. Age, professional status, smoking habits, comorbidities, body mass index, duration and status of disease, previous and ongoing treatments were also registered. Results: A total of 42 women with non-metastatic BC were enrolled with a disease duration of 11.50 months (71), mostly in stage II (53.60%) and under hormone therapy (38.10%). TGlittre performance time was 3.13 minutes (8.72). TGlittre performance time correlated with MIP (r = -0.373; p <0.01) and MEP (r = -0.414; p = 0.007) values and age (r = 0.711; p < 0.010). Patients with CV and endocrine comorbidities had higher TGlittre time values (p <0.01 and p = 0.019, respectively). Age was the only statistically significant predictor (p=0.041) of TGlittre variation.Conclusions: Women with BC presented decreased FC with mean values ​​of TGlittre duration higher than those described in the literature in healthy subjects.
Development of the Technology of Soft Camembert-type Cheese with Flowery rind in Morocco
Authors: NORA HAMDAOUI , Mohamed MOUNCIF , Zakariae MENNANE , Abdeloudoude OMARI , Mustapha MEZIANE 
Published: February 2021

Abstract
Camembert is a French cheese characterized by a soft paste and a flowery rind. Morocco imports camembert cheese paste as a raw material. Today, Moroccan cheese manufacturers are looking to uncover the secrets associated with making Camembert cheese including the ones facilitating the smooth running of the stages of its manufacture. In Morocco, this type of cheese is scarce, not fully enumerated and no studies have been conducted on it as of yet. This is why we tried to manufacture this type of cheese in the laboratory to valorize it in Morocco due to its growing importance in the international market. The objective of this work is the optimization of the production of soft cheese with a flowery rind such as Camembert, while determining the quantity of microorganisms used for the fermentation of milk. Four types of industrial ferments with pre-established doses were used in addition to rennet. Fifteen cheese samples were made. The physico-chemical parameters checked during the manufacturing tests were fat content, pH and titratable acidity. The results show that the production of cheese requires the use of milk of good microbiological quality as well as the selection of specific ferments depending on the type of cheese to make. The best amount of the ferments used to make Camembert-type cheese during this work is: from 0.6% to 0.8% mesophilic if the viability rate is more than 3.73 x102, 0.3 % to 0.4% thermophilic if the viability rate is more than 3.95 x 103, 1% to 5% yeast if the viability rate is more than 2.60 x 103 , and 2% to 10% mesophilic if the viability rate is more than 3.30 x 103. The most effective dose formula is two doses of Mesophiles for one dose of Thermophile. Or two doses of Penicillium Candidum mold for one dose of Geotrichum Candidum yeast. The microbiological quality of the milk used in this work and the cheese produced during this work is generally acceptable and conforms to Moroccan standards. During each Camembert production, whey quantity was measured. Cheese yield was determined by measuring cheese portions before and after ripening from a known quantity of milk. The sensory properties of dairy products are defined by their appearance, texture and flavor and are ultimately evaluated by tasting panels from the Agronomic and Veterinary Institute of Rabat.
Key Genes Associated With Prognosis and Metastasis of Clear Cell Renal Cell Carcinoma
Authors: Zhong Tingting , Jiang Zeying , Wang Xiangdong , Wang Honglei , Song Meiyi , Chen Wenfang , Yang Shicong 
Published: February 2021

Abstract
Background: Clear cell renal cell carcinoma (ccRCC) is a tumor with frequent hematogenous metastasis and is usually resistant with radiotherapy and chemotherapy. The mechanism of ccRCC metastasis still needs to be illustrated.Material and methods: The differentially expressed genes (DEGs) of three gene expression profiles (GSE85258, GSE105288 and GSE22541) downloaded from Gene Expression Omnibus (GEO) database were analyzed by GEO2R analysis, and co-expressed DEGs among them were sorted out by the online Venn drawing tool. The co-expressed DEGs were then investigated using Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and hub genes would be screened out based on protein-protein interaction network (PPI) established by STRING. After survival analysis performed on UALCAN website, possible key genes would be selected and then verified in ccRCC cell lines and ccRCC tissues (n=40). Statistical analysis of the above results was conducted using GraphPad Prism (Version 8.1.1).Results: 104 co-expressed DEGs were sorted from the three profiles. KEGG pathways revealed that these genes were enriched in the extracellular matrix (ECM)-receptor interaction, focal adhesion and PI3K-Akt signaling pathway. Survival analysis showed that among 17 hub genes, patients with higher expression of Procollagen C-Endopeptidase Enhancer (PCOLCE), Prolyl 4-Hydroxylase Subunit Beta (P4HB), Collagen Type VI Alpha 2 (COL6A2), and Collagen Type VI Alpha 3 (COL6A3) had a worse survival than those with lower expression. In vitro, the mRNA expression level of PCOLCE, P4HB and COL6A2 were 3 times, and COL6A3 16 times higher in metastatic ccRCC cell line Caki-1 than in corresponding primary cell line Caki-2. Immunohistochemistry results also showed higher expression of these 4 genes in metastatic ccRCC with statistical significance.Conclusion: PCOLCE, P4HB, COL6A2 and COL6A3 are upregulated in metastatic ccRCC and might be related to poor prognosis and distant metastases.
Eyelid Myokymia as a presumed manifestation of Coronavirus Disease 2019 (COVID-19)
Authors: Khan Hashim Ali , Shahzad Muhammad Aamir , Iqbal Junaid , Juwa Sohail Abbas , Khan Qaim Ali , Rehman Munib ur , Iqbal Fatima 
Published: February 2021

Abstract
Purpose
To report the eyelid myokymia in patients recovered from COVID-19 disease.
Methods
A cohort of 15 patients who developed eyelid myokymia during or immediate post-recovery of systemic disease were evaluated. Demographic, clinical characteristics, effect of age, and hospitalization on the disease course were studied. The disease course was evaluated every month for 3 months period.
Results
All, except 2, patients had complete resolution of lid myokymia within 3 months of onset. Mean ± SD myokymia recovery time was 44.1 ± 20.9 Days. Gender had no impact on the duration of disease. Age and duration of hospitalization had a strong positive correlation with myokymia recovery time (r = 0.8, p = 0.001 and r = 0.8, p = 0.01).
Conclusion
Eyelid myokymia may involve COVID-19 patients during or immediately after systemic recovery. While myokymia recovers gradually in all these patients; older age and longer duration of hospitalization are associated with slower recovery.