bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical Power Normalized to Predicted Body Weight is Associated with Mortality in Critically Ill Patients: A Cohort Study
Authors: Zhu Yanhong , Peng Wenyong , Zhen Shuai , Jiang Xiaofeng 
Published: May 2021

Abstract
Background: Mechanical power (MP), defined as the amount of energy produced by mechanical ventilation and released into the respiratory system, has long been considered a critical factor in the pathogenesis of ventilator-induced lung injury. However, our knowledge suggests that the effects of MP may be proportional to their involvement in total lung function size. Therefore, MP normalized to predicted body weight (norMP) should be greater than absolute MP value. The objective of this research is to determine the connection between norMP and mortality in critically ill patients who have been on invasive ventilation for at least 48 hours.Methods: This is a study of data stored in the databases of the MIMIC–III, which contains data of critically ill patients for over 50,000. The study involved critically ill patients who had been on invasive ventilation for at least 48 hours. norMP was the relevant exposure. The major endpoint was ICU mortality, the secondary endpoints were 30-day, 90-day mortality; ICU length of stay, the number of ventilator-free days at day 28.Result: The study involved a total of 1301 critically ill patients. This study revealed that norMP was correlated with ICU mortality [OR per quartile increase 1.20 (95% CI 1.07–1.35), p = 0.009]. Similarly, norMP was correlated with ventilator-free days at day 28, ICU length of stay. In the subgroup analysis, high norMP was associated with ICU mortality whether low or high Vt (OR 1.22, 95% CI 1.01–1.47, p = 0.040; OR 1.28, 95% CI 1.06–1.54, p = 0.011, respectively). But high norMP was associated with ICU mortality only in low PIP (OR 1.18, 95% CI 1.01–1.37, p = 0.034)Conclusion: Our findings indicate that higher norMP is independently linked with elevated ICU mortality and various other clinical findings in critically ill patients with a minimum of 48 hours of invasive ventilation.
Motor control and olfaction – Influence of pleasant and disgusting odors on the Adaptive Force
Authors: Schaefer Laura V , Dech Silas , Aehle Markus , Bittmann Frank N 
Published: May 2021

Abstract
The Adaptive Force (AF) characterizes the capability of the neuromuscular system to adapt to external forces. The aim was to measure the effects of different olfactory inputs on the AF of the hip and elbow flexors, respectively. The AF of 10 subjects was examined manually by experienced testers while smelling at sniffing sticks with neutral, pleasant or disgusting odors. The reaction force and the position of the tested limb were recorded by a handheld device. The results show, inter alia, a significantly lower maximal isometric AF and a significantly higher AF at the onset of oscillations with disgusting odor compared to pleasant or neutral odors (p < 0.001). The AF seems to reflect the functionality of the neuromuscular control, which can be impaired by disgusting olfactory inputs. An undisturbed functioning neuromuscular system appears to be characterized by a proper length-tension control and by an earlier onset of mutual oscillations during an external force increase under isometric conditions.
Liver Resection Combined with Radiotherapy versus Liver Resection Alone in the Treatment of Hepatocellular Carcinoma: A Population-based Study
Authors: Chen Lei , Guo Xiaopeng , Ren Yanqiao , Sun Tao , Zheng Chuansheng 
Published: May 2021

Abstract
BackgroundRadiotherapy has been used in the treatment of hepatocellular carcinoma (HCC) more widely. However, little research focus on comparing the efficacy of patients with liver resection combined with radiotherapy with that received liver resection alone. The study was conducted to evaluate whether the efficacy of liver resection combined with radiotherapy in the treatment of patients with HCC is better than liver resection alone.MethodsThe study utilized the data from SEER database. Patients diagnosed with HCC between 2004 and 2015 who received liver resection or the combination of liver resection and radiotherapy were included in the analysis. The propensity score matching model (PSM) was used to reduce selection bias.ResultsBefore PSM, the median overall survival (mOS) and median cancer-specific survival (mCSS) of patients treated with liver resection alone were longer than in patients treated with the combination of liver resection and radiotherapy (P<0.001). However, there was no statistically significant difference in mOS and mCSS between the groups after PSM (P>0.05). The subgroup analysis after PSM documented that patients with AJCC stage I and II who were treated with liver resection and radiotherapy had no longer mOS and mCSS than patients subjected to the combination of liver resection alone (P=0.151 and P=0.185). Similar results were obtained in the subgroup group of patients with a single tumor smaller than 5 cm.ConclusionThe combination of liver resection and radiotherapy does not prolong the survival of HCC patients more than liver resection alone.
The construction of the flow duration curve and the regionalization parameters analysis in the northwest of China
Authors: Luan Jinkai , Liu Dengfeng , Lin Mu , Huang Qiang 
Published: May 2021

Abstract
Daily runoff is the data to estimate the water resources in a river. In many catchments, the daily discharge is not well observed. Flow duration curve is an important characteristic of daily runoff, and important for the design of water conservancy projects. In the ungauged catchments, the evaluation of distribution functions and the parameters of flow duration curve is a helpful method to understand the characteristics of the flow. This study uses data from 19 hydrological stations to evaluate the applicability of 11 distribution functions to simulate flow duration curves in the northwest of China. The fitted flow duration curves are evaluated by Nash-Sutcliffe efficiency, the root mean square relative error and the coefficient of determination. The evaluation shows that, among the 11 distribution functions, the log normal model is the most suitable model to construct flow duration curves of 19 hydrological stations. Based on a multivariate linear regression model, a regional model of distribution parameters is constructed, including functions of watershed geomorphologic and climatic characteristics. The analysis of Baijiachuan hydrological station shows that the parameters a and b showed a decreasing trend. This study presents an innovative approach to evaluate regionalized parameters of flow duration curves considering the impacts of geomorphologic and climatic characteristics.
A holistic reliability system approach of a water distribution network in Saudi Arabia
Authors: Hadidi Laith , Mohammed Awsan , Ghaithan Ahmed , Tuffaha Firas 
Published: May 2021

Abstract
Saudi Arabia, with no perennial rivers, is considered to be an arid land where water losses in the water distribution network (WDN) supply increase the need for sea water desalination. This paper provides a reliability model to enhance the WDN for a water pumping station in Saudi Arabia. The paper utilizes the fault tree analysis (FTA) reliability tool to mitigate water supply stoppages. In the case under study, the pump station utilizes two groundwater aquifers in the eastern part of Saudi Arabia to meet the raw water demand through a water distribution network (28 km-long pipelines). Data has been gathered from the maintenance history to estimate the system reliability based on the loss of water by which each component of the system is assessed on its contribution to the overall system reliability and water supply. The findings revealed that system availability can be improved by adding a new pump in the booster station which further enhances the availability of the system to 99.99% and saves the WDN more than 740,974.60 gallons of water loss per year. It is hoped that the paper's recommendations will enhance reliability practices in similar water network stations.
Predicting LncRNA-Disease Association Based on Generative Adversarial
Network
Authors: Du Biao , Tang Lin , Liu Lin , Zhou Wei 
Published: May 2021

Background:
Increasing research reveals that long non-coding RNAs (lncRNAs) play an
important role in various biological processes of human diseases. Nonetheless, only a handful of
lncRNA-disease associations have been experimentally verified. The study of lncRNA-disease association
prediction based on the computational model has provided a preliminary basis for biological experiments
to a great degree so as to cut down the huge cost of wet lab experiments.

Objective:
This study aims to learn the real distribution of lncRNA-disease association from a limited
number of known lncRNA-disease association data. This paper proposes a new lncRNA-disease association
prediction model called LDA-GAN based on a Generative Adversarial Network (GAN).

Method:
Aiming at the problems of slow convergence rate, training instabilities, and unavailability of
discrete data in traditional GAN, LDA-GAN utilizes the Gumbel-softmax technology to construct a
differentiable process for simulating discrete sampling. Meanwhile, the generator and the discriminator
of LDA-GAN are integrated to establish the overall optimization goal based on the pairwise loss
function.

Results:
Experiments on standard datasets demonstrate that LDA-GAN achieves not only high stability
and high efficiency in the process of confrontation learning but also gives full play to the semisupervised
learning advantage of generative adversarial learning framework for unlabeled data, which
further improves the prediction accuracy of lncRNA-disease association. Besides, case studies show
that LDA-GAN can accurately generate potential diseases for several lncRNAs.

Conclusion::
We introduce a generative adversarial model to identify lncRNA-disease associations.
PSO-ELM with Modified Acceleration Coefficients for Classifying the Active Compound
Authors: Ratnawati Dian Eka , Marjono Marjono , Widodo Nashi 
Published: May 2021

Background:
The classification of active compounds based on their function using machine
learning is essential for predicting the function of new active compounds quickly. These classification
results are beneficial to accelerate the work of laboratory assistants in identifying the
function of active compounds. In this study, an active compound is represented by the Simplified
Molecular-Input Line-Entry System (SMILES) code.

Objective:
This paper proposes a modified acceleration coefficient to improve the PSO-ELM performance
for predicting the function of the SMILES code.

Method:
The research uses a machine-learning algorithm that is a combination of the Particle
Swarm Optimization and Extreme Learning Machine (PSO-ELM). ELM is used to classify the
SMILES code, while PSO is used to optimize ELM parameters, i.e., weight, bias, and the number
of hidden neurons. The important parameters that significantly influence the PSO performance are
acceleration coefficients. The acceleration coefficients, that are modified Sigmoid-Based Acceleration
Coefficient (SBAC), are introduced and compared with seven other acceleration coefficients.

Results:
The experimental results show that the sensitivity, specificity, accuracy, and Area Under
the Curve (AUC) of the proposed acceleration coefficients outperform all other acceleration coefficients.
The increased accuracy of the proposed can reach up to 2.64%, 5.84%, 7.93%, 8.44%, and
16.29% for Support Vector Machine (SVM), decision tree, AdaBoost, MLP Classifier, and Gaussian
Naïve Bayes algorithms, respectively.

Conclusion:
The acceleration coefficients affect the prediction accuracy of the SMILES code classification.
The proposed acceleration coefficients improve the performance of the PSO-ELM for
predicting the function of the SMILES code.
JOSE? INGENIEROS, INTELECTUAL. ENTRE LA CIENCIA, LA CULTURA Y LA POLI?TICA
Authors: Fraga Eugenia 
Published: May 2021

El presente trabajo tiene por objetivo indagar la singular forma de sociabilidad intelectual que el pensador argentino Jose? Ingenieros puso en pra?ctica con sus hechos, y sobre la cual asimismo re exiono? discursivamente en sus escritos. La metodo- logi?a que utilizaremos para llevarlo a cabo sera? el ana?lisis de textos del propio autor, asi? como de diversos comentaristas sobre su obra. Asi?, arribaremos a la conclusio?n de que dicha forma de sociabilidad se sustento? en un modo particular de intervenir simulta?neamente tanto en la esfera cienti? ca como en la poli?tica y en la cultural.
Palabras clave: Jose? Ingenieros - intelectual - ciencia - cultura - poli?tica
Abstract
is paper has the goal of analyzing the specific form of intellectual sociability that the Argentinean thinker Jose? Ingenieros put in practice through his acts, and upon which he reflected in his writings. We will methodologically do so by examining the author’s own papers, together with various secondary literature on his works. In this way, we will arrive in the conclusion that his form of sociability was founded on a particular way of simultaneously intervening in the scientific sphere as much as in the cultural and the political ones.
Keywords: Jose? Ingenieros - intellectual - science - culture - politics.
Resumo
Este trabalho tem como objetivo investigar a forma singular de sociabilidade intelectual que o pensador argentino Jose? Ingenieros implementou com seus fatos, e em que discursivamente tambe?m e? re etida em seus escritos. a meto- dologi?a que vai usar para realiza?-lo sera? a ana?lise de texto do autor, bem como va?rios comentadores de sua obra. Assim, chegamos a? conclusa?o de que esta forma de sociabilidade foi baseada em uma forma particular de intervenc?a?o simulta- neamente, tanto no a?mbito cienti? co e na poli?tica e cultural.
Palavras chaves: Jose? Ingenieros, intelectual - cie?ncia - cultura – poli?tica
INSTALARSE PARA TOMAR CONCIENCIA HISTO?RICA DEL CONTEXTO. APORTES PEDAGO?GICOS SOBRE LA CONSTITUCIO?N DEL SUJETO, EL CIUDADANO QUE SE CONFIGURA EN EL EJERCICIO DE LO COTIDIANO
Authors: Betancourt Cadavid Jorge Hernán 
Published: May 2021

El recorrido que describe este trabajo se funda en una lectura antropolo?gica filoso?fica, e histo?rico-pedago?gica sobre la constitucio?n del sujeto, ese que se hace ciudadano en la experiencia diaria de existir, dando sentido a todo lo que lo define. Para ello se abordan una diversidad de referentes teo?ricos que acercan a la obra del profesor Hugo Zemelman, cuyo trabajo tiene el cara?cter de faro orientador de la reflexio?n. El objetivo es contribuir a la construccio?n de otras miradas que reivindican a los sujetos, a los pueblos y los movimientos olvidados en el contexto nacional, y se proponen contribuciones a una propuesta pedago?gica cri?tica situada, que es el resultado de realidades histo?ricas.
Palabras clave: Colocacio?n, Gnoseologi?a, Sujeto, Subjetividad, Ciudadani?a.
Abstract
is paper aims to make an e ort on an anthropological-philosophical and historical pedagogical reading about the constitution of the Self, this one who exists on a daily basis experience, giving sense to everything that de ned it. For this, a diversity of theoretical approaches lead us close to the work of Hugo Zemelman, which work conduct this thinking. e main objective of this study is to contribute to other views upon the subjects, the people and the forgotten movements from a national context, and it is made contributions to a critical pedagogical proposal that is the result of historical realities.
Keywords: Placement, Gnoseology, Subject, Subjectivity, Citizenship.
Resumo
O percurso que descreve este trabalho e? baseado em um antropolo?gica leitura filoso?fica e histo?rico-pedago?gico sobre constituic?a?o do sujeito, que um cidada?o esta? em experie?ncia exixtir dia?ria, dando sentido a tudo o que a de ne. Isso requer uma variedade de quadro teo?rico para abordar o trabalho do professor Hugo Zemelman , cujo trabalho Tem o cara?ter de orientar a reflexa?o da luz. O objetivo e? contribuir para a construc?a?o de outros pontos de vista que a rmam assuntos, povos e movimentos esquecidos no contexto nacional e contribuic?o?es para uma proposta sa?o propostas pedagogia cri?tica localizado, que e? o resultado de realidades histo?ricas.
Palavras-chave: Posicionamento, Epistemologia, Sujeito, Subjetividade, Ciudadania
SIMULACIO?N DE COMPOSICIO?N DE SIMETRI?AS EN GEOGEBRA PARA SIMPLIFICAR LA TEORI?A DE LOS DIAMANTES EN LA PRA?CTICA DEL BILLAR
Authors: Berrío Valbuena Jesús David , Valbuena Duarte Sonia , Sánchez Anillo Rafael 
Published: May 2021

En este arti?culo se muestra una simulacio?n del juego del billar a tres bandas apoyada en el uso de geometri?a ba?sica y la utilizacio?n de un so ware de geometri?a dina?mica llamado Geogebra, para la visualizacio?n de propiedades de las transformaciones en el plano; esta simulacio?n permite simpli car el me?todo de pra?ctica de billar a tres bandas conocido como la “Teori?a de los diamantes para sistemas a tres bandas”. Haciendo uso de movimientos ri?gidos en el plano y las propiedades de la re exio?n de los cuerpos, se obtiene la “composicio?n de rebotes” que no es ma?s que la composicio?n de isometri?as, especi? camente de simetri?as axiales, para determinar con anticipacio?n el recorrido de la bola tiradora en tiros especiales, llamados bricoles (Berri?o, 2104).
Palabras clave: Billar a tres bandas, Composicio?n de simetri?as, Teori?a de los diamantes, Software de geometri?a dina?mica, GeoGebra.
Abstract
is paper works a simulation of the game of billiards (Carom billiard) based on the use of basic geometry and the use of a so ware of dynamic geometry called GeoGebra, for the visualization of properties of the transformations. is simulation makes possible to simplify the billiards practice method known as the “Diamond theory for Caron Billiard system”. Making use of rigid movements and the properties of the reflection of the bodies, we obtain the “composition of rebounds”. is composition is not more than an isometric composition, specifically of axial symmetries, to determine in advance the course of the ball in special shots, called bricoles (Berri?o, 2104).
Keywords: ree-band billiard, Composition of isometries, theory of diamonds, Dynamic geometry software, GeoGebra.
Resumo
Este artigo mostra uma simulac?a?o do jogo de bilhar a tre?s tabelas com base no uso da geometria ba?sica e o uso de um so ware de geometria dina?mica chamado GeoGebra, para a visualizac?a?o das propriedades das transformac?o?es. Esta simulac?a?o permite simpli car o me?todo de pra?tica de bilhar conhecido como “Teoria dos diamantes para sistemas de tre?s tabelas”. Fazendo uso de movimentos ri?gidos no plano e as propriedades do re exo dos corpos, obtemos a “composic?a?o dos rebotes” que na?o e? mais do que a composic?a?o das isometrias, especi camente de simetrias axiais, para determinar antecipadamente o curso da bola lmado em tiros especiais, chamados bricoles (Berri?o, 2104).
Palavras-chave: Bilhar a tre?s tabelas, Composic?a?o de simetrias, Teoria dos diamantes, Software de geometria dina?mica, GeoGebra.
ANA?LISIS DE LA TIPOLOGI?A DE LA PAZ DEL SIGLO XXI
Authors: De la Rosa Vázquez Cecilia Sarahí , Cabello Tijerina Paris Alejandro 
Published: May 2021

Este arti?culo de reflexio?n teo?rica tiene como punto de referencia la clasificacio?n de la tipologi?a de la paz del siglo XXI, propuesta por investigadores del Instituto de la paz y los conflictos de la Universidad de Granada. El eje central del trabajo es reflexionar las cuatro generaciones de la paz, incluyendo la paz imperfecta. El propo?sito del ana?lisis es comprender y re exionar la esencia de cada una de las definiciones. Como resultado se encontro? la relevancia que tiene la paz interna como base para lograr cualquier tipo de paz.
Palabras clave: Tipos de violencia, Generaciones de la paz, Cultura de paz, Paz neutra, Paz imperfecta.
Abstract
is article of theoretical reflection takes as a point of reference the classification of the typology of the peace of the 21st century, proposed by investigators of the Institute of the peace and the conflicts of the University of Granada. e backbone of the work is to reflection four generations of the peace, including the imperfect peace. e intention of the analysis is to understand and to think over the essence of each one of the de nations. Since result was the relevancy that takes the internal peace as a base to achieve any type of peace.
Keywords: Types of violence, Generations of the peace, Culture of peace, Neutral peace, Imperfect peace.
Resumo
Este artigo de reflexa?o teo?rica tem como ponto de refere?ncia a classificac?a?o da tipologia da paz do se?culo XXI, proposta por pesquisadores do Instituto da Paz e os conflitos da Universidade de Granada. O eixo central do trabalho e? realizar uma re exa?o sobre as quatro gerac?o?es da paz, incluindo a paz imperfeita. O propo?sito da ana?lise e? compreender e pensar a esse?ncia de cada uma das definic?o?es. Como resultado temos a releva?ncia que a paz interna tem como base para alcanc?ar qualquer tipo de paz.
Palavras-chave: Tipos de violencia, Gerac?o?es de paz, Cultura de paz, Paz neutra, Paz imperfeita.
PHARMACOGNOSTICAL EVALUATION OF EMBELIA RIBES AND CAMELLIA SINENSIS: COMPARATIVE STUDIES OF THEIR ANTHELMINTIC ACTIVITY
Authors: SEEMA  , KUMAR ARVIND , AGGARWAL KSHITIZ , KUMAR ASHOK 
Published: May 2021

Objective: The present research work deals with the establishment of a standardization parameter for the Pharmacognositical evaluation of the plant Embelia Ribes and Camellia sinensis. Embelia Ribes is widely using in parasitic intestinal infection, however; Camellia sinensis is mainly used in the beverage preparation, for their Antioxidant activity but their anthelmintic effect is unknown. The present study aims to find out the effect of Camellia sinensis against pheritima Posthuma and compare their anthelmintic effect with Embelia Ribes.
Methods: The study has been performed under the different parameters 1). The physicochemical parameter includes total Ash value, acid insoluble ash value, water-soluble ash value, moisture content, and foreign organic matter 2). The phytochemical investigation includes the Extraction of Embelia Ribes and Camellia sinensis in different solvents in the increasing order of their polarity with Petroleum ether, chloroform, ethanol, distilled respectively and showed the presence of Alkaloids, carbohydrates, glycosides, tannins, flavonoids, phenolic compounds. 3) The pharmacological studies include the In vitro anthelmintic effect of Embellia Ribes and Camellia sinensis (ethanolic extract) against Pheritima Posthuma. The paralysis time and death time were studied.
Results: Shows the physic-chemical parameters such as total Ash value, acid insoluble ash value, water-soluble ash value, moisture content and foreign organic matter, which was determined to be not more than 8.98%, 1.5%, 7.8%, 3.2% and 0.25% in Embelia ribes as well as 7.78%, 1.6%, 8%, 2.2% and 0.21% in Camellia sinensis. Anthelemintic effect of Embellia ribes and Camellia sinensis (ethanolic extract) were investigated by measuring the paralysis time (75+3.76, 60+4.30, 48+4.40 and 73.32+3.80, 53.34+2.50, 38.55+3.45 respectively) and death time (140+2.82, 135+9.95, 97.55+4.25 and 124.85+5.30, 110.82+5.80, 80.30+2.80) at three different concentration 25 mg, 50 mg, 100 mg, against Pheritima posthuma and compares with the standard drug (Albendazole).
Conclusion: Camellia sinensis (ethanolic extract) extract and affords protection against helminthes (Pheritima Posthuma) and results show that Camellia sinensis is as effective as embellia ribes.