bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consideration of Initial Cloud Droplet Size Distribution Shapes in Quantifying Different Entrainment‐Mixing Mechanisms
Authors: Luo Shi , Lu Chunsong , Liu Yangang , Gao Wenhua , Zhu Lei , Xu Xiaoqi , Li Junjun , Guo Xiaohao 
Published: June 2021

AbstractEntrainment‐mixing process significantly affects cloud micro/macrophysics and the evaluation of aerosol indirect effects. However, it is still an open question as to how to quantify entrainment‐mixing mechanism for broad cloud droplet size distributions (CDSDs). Here, CDSDs with different spectral widths are used to initialize the Explicit Mixing Parcel Model to address this problem, and microphysical properties are compared for different CDSD widths. For relatively broad CDSDs, as the number concentration and liquid water content decrease, the volume‐mean radius and mean radius increase, which is opposite to the scenario for relatively narrow CDSDs and the homogeneous/inhomogeneous conceptual model. For the relatively broad CDSDs, such relationships could be mistaken as inhomogeneous mixing with subsequent ascent in analysis of the conventional microphysical mixing diagram. This then causes traditional homogenous mixing degrees to be unrealistically negative and not applicable for relatively broad CDSDs. New measures are introduced to explicitly account for the effect of CDSD spectral shapes on quantifying entrainment‐mixing mechanism. The new measures yield reasonable ranges of values that conform to the dynamical measures such as the Damköhler and transitional scale numbers, and their temporal variation can be explained physically. This study extends the measures of homogeneous mixing degrees from narrow to broad CDSDs, and sheds new light on the consideration of CDSD shapes in parameterizations of entrainment‐mixing mechanism.
The Effects of Ice Floe‐Floe Interactions on Pressure Ridging in Sea Ice
Authors: Damsgaard A. , Sergienko O. , Adcroft A. 
Published: June 2021

AbstractThe mechanical interactions between ice floes in the polar sea‐ice packs play an important role in the state and predictability of the sea‐ice cover. We use a Lagrangian‐based numerical model to investigate such floe‐floe interactions. Our simulations show that elastic and reversible deformation offers significant resistance to compression before ice floes yield with brittle failure. Compressional strength dramatically decreases once pressure ridges start to form, which implies that thicker sea ice is not necessarily stronger than thinner ice. The mechanical transition is not accounted for in most current sea‐ice models that describe ice strength by thickness alone. We propose a parameterization that describes failure mechanics from fracture toughness and Coulomb sliding, improving the representation of ridge building dynamics in particle‐based and continuum sea‐ice models.
Paleomagnetic Constraints on the India–Asia Collision and the Size of Greater India
Authors: Bian Weiwei , Yang Tianshui , Peng Wenxiao , Wang Suo , Gao Feng , Zhang Shihong , Wu Huaichun , Li Haiyan , Cao Liwan , Jiang Tian , Wang Huapei 
Published: June 2021

AbstractThe timing and location India–Asia collision is crucial to understanding the evolution of the Himalayan–Tibetan orogen and global climate change; however, estimates of the timing of the India–Asia collision and the size of Greater India remain highly controversial. We report here the first reliable early Eocene paleomagnetic results from the Zhepure Formation limestone in the Tethyan Himalaya (TH). Both positive fold and reversal tests indicate a primary origin. The tilt‐corrected site‐mean direction is Ds = 332.6°, Is = 20.1°, ks = 90.9, α95 = 2.8° (N = 30). The site‐mean inclination increased from 20.1° to 27.5° after inclination shallowing correction, yielding a paleopole at 61.2°N, 337.3°E, A95 = 2.6° and a corresponding paleolatitude of 15.2° ± 2.6°N for the reference point (29.5°N, 91.0°E). Our new paleomagnetic results, together with the reliable Cretaceous to Paleogene paleomagnetic results from the TH, Lhasa terrane and Indian craton, suggest that there was ∼900–1,140 km north‐south crustal shortening occurred between the TH and the Indian craton, and that India collided with Asia at no later than ∼51–49.5 Ma.
Probabilistic Near‐Field Tsunami Source and Tsunami Run‐up Distribution Inferred From Tsunami Run‐up Records in Northern Chile
Authors: Lee Jun‐Whan , Irish Jennifer L. , Weiss Robert 
Published: June 2021

AbstractUnderstanding a tsunami source and its impact is vital to assess a tsunami hazard. Thanks to the efforts of the tsunami survey teams, high‐quality tsunami run‐up data exist for contemporary events. Still, it has not been widely used to infer a tsunami source and its impact mainly due to the computational burden of the tsunami forward model. In this study, we propose a TRRF‐INV (Tsunami Run‐up Response Function‐based INVersion) model that can provide probabilistic estimates of a near‐field tsunami source and tsunami run‐up distribution from a small number of run‐up records. We tested the TRRF‐INV model with synthetic tsunami scenarios in northern Chile and applied it to the 2014 Iquique, Chile, tsunami event as a case study. The results demonstrated that the TRRF‐INV model can provide a reasonable tsunami source estimate to first order and estimate tsunami run‐up distribution well. Moreover, the case‐study results agree well with the United States Geological Survey report and the global Centroid Moment Tensor solution. We also analyzed the performance of the TRRF‐INV model depending on the number and the uncertainty of run‐up records. We believe that the TRRF‐INV model has the potential for supporting accurate hazard assessment by (1) providing new insights from tsunami run‐up records into the tsunami source and its impact, (2) using the TRRF‐INV model as a tool to support existing tsunami inversion models, and (3) estimating a tsunami source and its impact for ancient events where no data other than estimated run‐up from sediment deposit data exist.
Quantifying Nitrous Acid Formation Mechanisms Using Measured Vertical Profiles During the CalNex 2010 Campaign and 1D Column Modeling
Authors: Tuite Katie , Thomas Jennie L. , Veres Patrick R. , Roberts James M. , Stevens Philip S. , Griffith Stephen M. , Dusanter Sebastien , Flynn James H. , Ahmed Shaddy , Emmons Louisa , Kim Si‐Wan , Washenfelder Rebecca , Young Cora , Tsai Catalina , Pikelnaya Olga , Stutz Jochen 
Published: June 2021

AbstractNitrous acid (HONO) is an important radical precursor that can impact secondary pollutant levels, especially in urban environments. Due to uncertainties in its heterogeneous formation mechanisms, models often under predict HONO concentrations. A number of heterogeneous sources at the ground have been proposed but there is no consensus about which play a significant role in the urban boundary layer. We present a new one‐dimensional chemistry and transport model which performs surface chemistry based on molecular collisions and chemical conversion, allowing us to add detailed HONO formation chemistry at the ground. We conducted model runs for the 2010 CalNex campaign, finding good agreement with observations for key species such as O3, NOx, and HOx. With the ground sources implemented, the model captures the diurnal and vertical profile of the HONO observations. Primary HOx production from HONO photolysis is 2–3 times more important than O3 or HCHO photolysis at mid‐day, below 10 m. The HONO concentration, and its contribution to HOx, decreases quickly with altitude. Heterogeneous chemistry at the ground provided a HONO source of 2.5 × 1011 molecules cm−2 s−1 during the day and 5 × 1010 molecules cm−2 s−1 at night. The night time source was dominated by NO2 hydrolysis. During the day, photolysis of surface HNO3/nitrate contributed 45%–60% and photo‐enhanced conversion of NO2 contributed 20%–45%. Sensitivity studies addressing the uncertainties in both photolytic mechanisms show that, while the relative contribution of either source can vary, HNO3/nitrate is required to produce a surface HONO source that is strong enough to explain observations.
A New Messinian87Sr/86Sr Curve for the Ain El Beida Section (Morocco): An Atlantic Perspective of the Mediterranean Salinity Crisis
Authors: Manzi Vinicio , Gennari Rocco , Lugli Stefano , Reghizzi Matteo , Roveri Marco 
Published: June 2021

AbstractWe present a new87Sr/86Sr curve for the time interval between 6.5 and 5.5 Ma of the Ain El Beida section (AEB, Atlantic side of Morocco). The location and the precessional‐scale resolution of our curve allow to investigate the possible relationships between global paleoclimatic and palaeoceanographic trends and the high‐amplitude hydrological changes of the Mediterranean during the Messinian salinity crisis (MSC). The values, obtained from planktic foraminifers, plot in the upper portion of the global ocean curve and show long‐ (at eccentricity scale) and short‐term (precessional scale) oscillations; the latter are more evident during the maximum of eccentricity for both the 100 and 400 ka components, between 6.00 and 5.85 Ma. Negative87Sr/86Sr anomalies are observed at insolation minima in phase with δ18O maxima, marking the glacial stages from TG34 to TG26. It is unclear whether these oscillations originated from local (river runoff) or global (glacial/interglacial) climatic forcing. Conversely, the evaporites of the coeval Primary Lower Gypsum (5.97–5.62 Ma) accumulated in the Mediterranean at insolation minima show positive anomalies at glacial stages TG32, 30, 28, and 26. Such an opposite trend is possibly related to the greater sensitivity of the Mediterranean Sea to river runoff during insolation maxima compared to the global ocean, as recorded at the Moroccan Atlantic margin. These observations and the deviation toward lower values of the Mediterranean Sr isotope curve starting at around 6.5 Ma, support the hypothesis of a progressive restriction of the Atlantic connections since the early Messinian, leading to the MSC.
Assembly of multicomponent structures from hundreds of micron-scale building blocks using optical tweezers
Authors: Melzer Jeffrey E. , McLeod Euan 
Published: June 2021

AbstractThe fabrication of three-dimensional (3D) microscale structures is critical for many applications, including strong and lightweight material development, medical device fabrication, microrobotics, and photonic applications. While 3D microfabrication has seen progress over the past decades, complex multicomponent integration with small or hierarchical feature sizes is still a challenge. In this study, an optical positioning and linking (OPAL) platform based on optical tweezers is used to precisely fabricate 3D microstructures from two types of micron-scale building blocks linked by biochemical interactions. A computer-controlled interface with rapid on-the-fly automated recalibration routines maintains accuracy even after placing many building blocks. OPAL achieves a 60-nm positional accuracy by optimizing the molecular functionalization and laser power. A two-component structure consisting of 448 1-µm building blocks is assembled, representing the largest number of building blocks used to date in 3D optical tweezer microassembly. Although optical tweezers have previously been used for microfabrication, those results were generally restricted to single-material structures composed of a relatively small number of larger-sized building blocks, with little discussion of critical process parameters. It is anticipated that OPAL will enable the assembly, augmentation, and repair of microstructures composed of specialty micro/nanomaterial building blocks to be used in new photonic, microfluidic, and biomedical devices.
Dapagliflozin increases the lean-to total mass ratio in type 2 diabetes mellitus
Authors: Wolf Vaneza Lira W. , Breder Ikaro , de Carvalho Luiz Sérgio F. , Soares Alexandre A. S. , Cintra Riobaldo M. , Barreto Joaquim , Munhoz Daniel B. , Kimura-Medorima Sheila T. , Nadruz Wilson , Guerra-Júnior Gil , Quinaglia Thiago , Muscelli Elza , Sposito Andrei C. ,   on behalf of Addenda-BHS2 trial investigators
Published: June 2021

AbstractWe compared the effect of dapagliflozin versus glibenclamide on the ratio of lean-to total mass in patients with type 2 diabetes mellitus, carotid subclinical atherosclerosis, HbA1c 7.0–9.0% and 40–70 years-old. Ninety-eight patients (61% male; mean age 57 ± 7 years) were randomized into dapagliflozin 10 mg/day or glibenclamide 5 mg/day on top of metformin. Body composition was measured by Dual Energy X-Ray at randomization and after 12 weeks of treatment. Glycemic control was equivalent in both groups. Dapagliflozin decreased total body mass (−2741 g [95% CI: −3360 to 1945]; p < 0.001) and lean mass (−347 g [95% CI: −761 to −106]; p < 0.001), while glibenclamide increased total body mass (1060 g [95% CI: 140 to 1836]; p < 0.001) and lean mass (929 g [95% CI: 575 to 1283]; p < 0.001) for the differences between arms. The lean-to-total mass ratio increased by 1.2% in the dapagliflozin group and 0,018% in the glibenclamide group (p < 0.001). Dapagliflozin reduced the risk of a negative balance in the lean-to total mass ratio [OR: 0.16 (95% CI: 0.05 to 0.45); p < 0.001] even after adjustment for baseline lean-to total mass ratio, waist circumference, HOMAIR, HbA1c, mean of the two hands handgrip strength and gait speed [OR: 0.13 (95% CI: 0.03–0.57); p < 0.007]. In conclusion, under equivalent glycemic control, dapagliflozin reduced total body mass but increased the ratio of lean-to-total mass when compared with glibenclamide.
Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis
Authors: García-Navas Rósula , Liceras-Boillos Pilar , Gómez Carmela , Baltanás Fernando C. , Calzada Nuria , Nuevo-Tapioles Cristina , Cuezva José M. , Santos Eugenio 
Published: June 2021

AbstractSOS1 ablation causes specific defective phenotypes in MEFs including increased levels of intracellular ROS. We showed that the mitochondria-targeted antioxidant MitoTEMPO restores normal endogenous ROS levels, suggesting predominant involvement of mitochondria in generation of this defective SOS1-dependent phenotype. The absence of SOS1 caused specific alterations of mitochondrial shape, mass, and dynamics accompanied by higher percentage of dysfunctional mitochondria and lower rates of electron transport in comparison to WT or SOS2-KO counterparts. SOS1-deficient MEFs also exhibited specific alterations of respiratory complexes and their assembly into mitochondrial supercomplexes and consistently reduced rates of respiration, glycolysis, and ATP production, together with distinctive patterns of substrate preference for oxidative energy metabolism and dependence on glucose for survival. RASless cells showed defective respiratory/metabolic phenotypes reminiscent of those of SOS1-deficient MEFs, suggesting that the mitochondrial defects of these cells are mechanistically linked to the absence of SOS1-GEF activity on cellular RAS targets. Our observations provide a direct mechanistic link between SOS1 and control of cellular oxidative stress and suggest that SOS1-mediated RAS activation is required for correct mitochondrial dynamics and function.
Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases
Authors: Sun Jialiang , Li Yanan 
Published: June 2021

Abstract
Macrolide antibiotics are one of the most commonly used broad-spectrum antibiotics. They have an inhibitory effect on a variety of respiratory pathogens; besides, they have non-anti-infective effects, including anti-inflammatory, regulating airway secretion, immune regulation, and other effects. A growing number of studies have shown that the non-anti-infective effects of macrolides have important and potential value in the treatment of pediatric chronic airway diseases; the therapy was described as “long-term, low-dose usage”; unfortunately, there is no guideline or consensus that applies to children. To better carry out the mechanism and clinical research of non-anti-infective effect and promote its rational use in children, the authors summarize the evidence of the usage of long-term, low-dose macrolide antibiotic therapy (LLMAT) in the treatment of chronic airway diseases in children and the progress in recent years.

Impact

This review summarizes the evidence (mostly in recent 5 years) of the usage of long-term, low-dose macrolide antibiotic therapy in the treatment of chronic airway diseases.

The recent studies and guidelines support and enrich the point that long-term, low-dose macrolide antibiotic therapy has potential benefit for children with severe asthma, CF, non-CF bronchiectasis, and BO, which provides clinical references and is of clinical interest.

Long-term, low-dose macrolide antibiotic therapy has good safety, and no serious events have been reported; however, potential cardiac side effects and macrolide resistance should be clinically noted.
H2A.Z acetylation by lincZNF337-AS1 via KAT5 implicated in the transcriptional misregulation in cancer signaling pathway in hepatocellular carcinoma
Authors: Yuan Yin , Cao Wen , Zhou Hongbing , Qian Haixin , Wang Honggang 
Published: June 2021

AbstractIn eukaryotes, histones and their variants are essential for chromatin structure and function; both play important roles in the regulation of gene transcription, as well as the development of tumors. We aimed to explore the genomics data of hepatocellular carcinoma (HCC), combined with literature analysis, in terms of the histone variant H2A.Z. Cell phenotype assay confirmed the effect of H2A.Z on the proliferation, metastasis, apoptosis, and cell cycle of HCC cells. H2A.Z was shown to function via the tumor dysregulation signaling pathway, with BCL6 as its interacting protein. In addition, the acetylation level of H2A.Z was higher in HCC and was related to tumor formation. We found the acetylation of H2A.Z to be related to and regulated by lincZNF337-AS1. LincZNF337-AS1 was found to bind to H2A.Z and KAT5 at different sites, promoting the acetylation of H2A.Z through KAT5. We concluded that, in HCC, H2A.Z is an oncogene, whose acetylation promotes the transcription of downstream genes, and is regulated by lincZNF331-AS1.
Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress
Authors: Zhan Yanxia , Du Junxian , Min Zhihui , Ma Li , Zhang Wei , Zhu Wei , Liu Yonglei 
Published: June 2021

AbstractHypoxia is a common phenomenon in solid tumors. The roles of exosomes from hypoxic breast cancer stroma are less studied. So, the study was aimed to investigate the role of exosomes from hypoxic cancer-associated fibroblasts (CAFs) cells in breast cancer. The circRNA array analysis was performed to screen differential expressed circRNAs between hypoxic and normoxic CAFs exosomes. Candidate circHIF1A (circ_0032138) was screened out and it was confirmed that circHIF1A was up-regulated in the exosomes from hypoxic CAFs and their exosomes. Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic CAFs exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression. In a summary, circHIF1A from hypoxic CAFs exosomes played an important role in stem cell properties of breast cancer. CircHIF1A may act as a target molecule of breast cancer therapy.
Head Impulse Test Paradigm and Suppression Head Impulse Test Paradigm in Individuals With and Without Motion Sickness
Authors: Kumar Rakesh T. , Sinha Sujeet Kumar 
Published: June 2021

Purpose
This study aimed to assess the vestibuloocular reflex (VOR) gain using both the Head Impulse Test Paradigm (HIMP) and Suppressive Head Impulse Test Paradigm (SHIMP) in individuals with motion sickness.

Method
Fifty eight participants (58 females) in the age range of 18–25 years were recruited for the study. The participants were divided into two groups, Group A had 29 participants with no motion sickness, and Group B consisted of 29 individuals who had motion sickness. All the participants underwent HIMP and SHIMP testing.

Results
None of the participants had a presence of saccades in the HIMP technique, and all the participants in both the groups had anticompensatory saccades in SHIMP technique. Also, there was no difference in VOR gain or VOR gain asymmetry between individuals with and without motion sickness using HIMP and SHIMP Techniques.

Conclusions
The results of the study show no differences in VOR gain between individuals with and without motion sickness. It has been reported that only low frequencies trigger the motion sickness. Since the Video Head Impulse Test assesses the high frequency, it may not be an ideal technique to evaluate the vestibular system in individuals with motion sickness.
Intraword Variability in French-Speaking Monolingual and Bilingual Children
Authors: Kehoe Margaret M. , Cretton Emilie 
Published: June 2021

Purpose
This study examines intraword variability in 40 typically developing French-speaking monolingual and bilingual children, aged 2;6–4;8 (years;months). Specifically, it measures rate of intraword variability and investigates which factors best account for it. They include child-specific ones such as age, expressive vocabulary, gender, bilingual status, and speech sound production ability, and word-specific factors, such as phonological complexity (including number of syllables), phonological neighborhood density (PND), and word frequency.

Method
A variability test was developed, consisting of 25 words, which differed in terms of phonological complexity, PND, and word frequency. Children produced three exemplars of each word during a single session, and productions of words were coded as variable or not variable. In addition, children were administered an expressive vocabulary test and two tests tapping speech motor ability (oral motor assessment and diadochokinetic test). Speech sound ability was also assessed by measuring percent consonants correct on all words produced by the children during the session. Data were entered into a binomial logistic regression.

Results
Average intraword variability was 29% across all children. Several factors were found to predict intraword variability including age, gender, bilingual status, speech sound production ability, phonological complexity, and PND.

Conclusions
Intraword variability was found to be lower in French than what has been reported in English, consistent with phonological differences between French and English. Our findings support those of other investigators in indicating that the factors influencing intraword variability are multiple and reflect sources at various levels in the speech processing system.