bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pinpointing Genomic Regions Associated with Root System Architecture in Rice Through an Integrative Meta-Analysis Approach
Authors: Daryani Parisa , Ramandi Hadi Darzi , Dezhsetan Sara , Mansuri Raheleh Mirdar , Salekdeh Ghasem Hosseini , Shobbar Zahra-Sadat 
Published: July 2021

Abstract
Root system architecture (RSA) is an important factor for facilitating water and nutrient uptake from deep soils and adaptation to drought stress conditions. In the present research, an integrated meta-analysis approach was employed to find candidate genes and genomic regions involved in rice RSA traits. A whole-genome meta-analysis was performed for 425 initial QTLs reported in 34 independent experiments controlling RSA traits under control and drought stress conditions in the previous twenty years. Sixty-four consensus meta-QTLs (MQTLs) were detected, unevenly distributed on twelve rice chromosomes. The confidence interval (CI) of the identified MQTLs was obtained as 0.11-14.23 cM with an average of 3.79 cM, which was 3.88 times narrower than the mean CI of the original QTLs. Interestingly, 52 MQTLs were co-located with SNP peak positions reported in rice genome-wide association studies (GWAS) for root morphological traits. The genes located in these RSA related MQTLs were detected, and explored to find the drought-responsive genes in the rice root based on the RNA-seq and microarray data. Multiple RSA and drought tolerance associated genes were found in the MQTLs including the genes involved in auxin biosynthesis or signaling (e.g. YUCCA, WOX, AUX/IAA, ARF), root angle (DRO1-related genes), lateral root development (e.g. DSR, WRKY), root diameter (e.g. OsNAC5), plant cell wall (e.g. EXPA) and lignification (e.g. C4H, PAL, PRX and CAD). The genes located both in the SNP peak positions and in the high-overview-index MQTLs for root architecture traits are suggested as novel candidate genes for further functional analysis.. The promising candidate genes and MQTLs would be applicable to genetic engineering and MQTL-assisted breeding of root phenotypes aimed at improving yield potential, stability and performance in a water-stressed environment.
Investigation of Water Condensation from Humid Air and The Feasibility Analysis of its Potable Characteristics
Authors: Kumar Dinesh , Agarwal Vidhu , Tiwari Akhilesh 
Published: July 2021

Abstract
Freshwater scarcity will be one of the most challenging issues in the coming time. Atmospheric water harvesting could be a solution to such a problem in semi-arid and arid regions. This could help to fill the thirst as well as, improve irrigation. There are several methods available retrieve water vapour but research is needed for a cost-effective and efficient method with optimized parameters. This method utilizes the Peltier device for water condensation and in-depth experimental analysis has been done to investigate the optimal conditions for maximum water production from atmospheric moisture. The experimental setup was designed in such a way that during the condensation process, the online monitoring of water condensate was recorded for more than 10-12 hours each day using a digital electronic weighing balance with an accuracy of 0.01 gram. The produced water was tested for the physico-chemical parameters of condensed water, and the results were discussed with a comparison to the standard results. The rate of produced condensed water from humid air was achieved as 19 L/m2-day. This study will help us to develop applications in the field of alternative water resources near the coastal areas for potability.
A realist evaluation of the continuum of HIV services for men who have sex with men
Authors: Dunbar Willy , Pierre Marie Colette Alcide Jean , Pétion Jacky S , Labat Aline , Maulet Nathalie , Coppieters Yves 
Published: July 2021

Abstract
BackgroundMen who have Sex with Men (MSM) represent the risk group that are disproportionately most affected by the human immunodeficiency virus (HIV) and continue to drop-off from the steps of the continuum of HIV services that have been adopted to overcome poor engagement and retention in care. This realist evaluation aimed at: 1) describing the evaluation carried out in Haiti aiming to ascertain why, how and under which circumstances MSM are linked and retained along the continuum, 2) assessing the outcomes of this approach and 3) exploring the motivators and facilitators for the HIV continuum of services through mechanisms and pathways. MethodsGuided by a realist approach, first, an initial program theory (IPT) was developed based on literature and frameworks review, participant observations and discussions with stakeholders. Then, the IPT was tested using a mixed method explanatory study: a quantitative phase to build the continuum from a cross-sectional analysis, and a qualitative phase to explore the motivators and facilitators related to proper linkages along the continuum. Finally, the IPT was refined by eliciting the mechanisms and pathways for outcomes improvement.ResultsThe results showed that the current service delivery model is suboptimal in identifying, engaging, linking and retaining MSM, resulting in loss to follow-up at every step of the continuum and failure to fully realize the health and prevention benefits of antiretroviral. However, the mechanisms through which linkages across the continuum can be improved are: self-acceptance, sense of community support and sense of comprehensive and tailored HIV services. These mechanisms are based on 10 different pathways: self-esteem, awareness and pride, perception of HIV risk, pcceptance and HIV status, addressing community stigma, strengthening of MSM organizations and community networks, societal acceptation and tolerance, stigma reduction training for healthcare providers, engagement of peers as educators and navigators and, adapted services delivery through drug dispensing points and mobile technology and financial assistance.ConclusionsThe study findings show that engagement, adherence and retention to the continuum of HIV service for MSM are affected by a multi-layer of factors, thus highlighting the importance of taking a comprehensive approach to improve the program.
Pre-implementation Assessment of Tobacco Cessation Interventions in Substance Use Disorder Residential Programs in California
Authors: Fokuo J. Konadu , McCuistian Caravella L. , Masson Carmen L. , Gruber Valerie A. , Straus Elana , Wong Jessie , Guydish Joseph R. 
Published: July 2021

Abstract
Background: Across the United States, substance use disorder (SUD) treatment programs vary in terms of their tobacco-related policies and cessation services offered to clients. Guided by the Consolidated Framework for Implementation Research (CFIR), the current study identified key factors that may influence the implementation of tobacco related cessation policies and services in residential SUD programs. Methods: We conducted semi-structured qualitative interviews with sixteen residential treatment program directors in California. The analysis was guided by a deductive approach using CFIR domains and constructs to develop codes and identify themes. ATLAS.ti software was used to facilitate thematic analysis of interview transcripts.Findings: Guided by the CFIR constructs, themes that arose as facilitators for implementation included the relative advantage of the intervention compared with current practice, external policies/incentives to support tobacco related policy, program directors strong commitment and high self-efficacy to incorporate cessation into SUD treatment, and recognizing the importance of planning and engaging opinion leaders. Potential barriers included the SUD recovery culture, low stakeholder engagement, organizational culture, lack of workforce expertise and, lack of reimbursement for smoking cessation services.Conclusion: The CFIR provided a valuable framework for evaluating factors that may influence implementation of tobacco policies and services in SUD treatment. In order to support successful implementation, residential SUD programs (staff and clients) require extensive education on the effectiveness of tobacco cessation efforts on health outcomes and publicly funded SUD treatment programs should receive support through expanded reimbursement for tobacco cessation services.
Examining Success Factors in Deprescribing Proposals from Community Pharmacists
Authors: Osada Shin 
Published: July 2021

Abstract
Background: Polypharmacy is a critical issue that affects elderly people in particular. In Japan, fees to support deprescription are calculated bycommunity pharmacists who propose deprescribing 2 or more medications for patients prescribed 6 or more. However, the fees are rarely calculated.The objective of this study is toexamine success factors in deprescribing proposals submitted bycommunity pharmacists to prescribing doctors.Methods: Tracing reports submitted from Aug 2017 to Mar 2020 were investigated retrospectively to uncover factors that influenced the success of deprescribing using statisticalanalyses.Results:One hundred and twenty-three unique tracing reports were submitted to the prescribing doctors. Of these, 67 reports were successful in deprescribing and 56 failed; the success rate was 54.5%. Deprescribing proposals with existingunused medications significantly increased the deprescribing success rate. Possible adverse events, potentially inappropriate medications, and overlapping medications with the same effecttended to increase the success rate, but not significantly. Whether the pharmacist experienced face-to-face communication with the prescribing doctors did not significantly influence the outcome.Conclusions:Tracing reports with deprescribing proposals submitted by community pharmacists may help resolve problems arising frompolypharmacy. Mentioning unused medications could increase the deprescribing success rate.Trial registration: This study did not registered due to purely observational study.
A Fiducial-Aided Reconfigurable Artefact for the Estimation of Volumetric Errors of Multi-axis Ultra-Precision Machine Tools
Authors: Wang Shixiang , Cheung Chi Fai , Kong Lingbao 
Published: July 2021

Abstract
In this paper, a fiducial-aided reconfigurable artefact is presented for estimating volumetric errors of a multi-axis machine tools. The artefact makes use of an adjustable number of standard balls as fiducials to build a 3D artefact which has been calibrated on a coordinate measuring machine (CMM). This 3D artefact shows its reconfigurability in its number of fiducials and their locations according to the characteristics of workpieces and machine tools. The developed kinematics of the machine tool was employed to identify the volumetric errors in the working space by comparing the information acquired by the on-machine metrology with that by the CMM. Experimental studies are conducted on a five-axis ultra-precision machine tools mounted with the 3D artefact composed of five standard spheres. Factors including the gravity effect and measurement repeatability are examined for the optimization of the geometry of the artefact. The results show that the developed 3D artefact is able to provide information of the volume occupied by the workpiece.
Preparation and Photocatalytic Characterization of Modified TiO2/Nd/rice Husk Ash Nanomaterial for Rifampicin Removal in Aqueous Solution
Authors: Ngoc Thuy Dang Thi , Thi Ha Nguyen , Van Anh Ngo , Thi Sen Nguyen , Duc Dung Nguyen , Hoang Nam Nguyen 
Published: July 2021

Abstract
The neodymium doping of titanium dioxide with content of Nd varying from 0.01 to 0.8% was conducted by the sol-gel hydrothermic method. TiO2/Nd is then coated on rice husk ash to produce modified TiO2/Nd/rice husk ash material using Nd content of 0.36% w/w. The materials’ structure characteristic and photocatalytic properties have been analyzed by the XRD, EDX, TEM, SEM, forbidden zone energy (Eg) and specific surface area (BET). TiO2/Nd material shows a higher photocatalytic decomposition capacity in comparison to TiO2 and depended on the Nd content. The Rifampicin removal efficiency of TiO2/Nd materials with Nd contents ranged from 0.36 to 0.80% had an increase of about 40% higher than that of TiO2/Nd containing Nd from 0.01 to 0.28%. This new photocatalytic TiO2/Nd/rice husk ash material is used to decompose Rifampicin. Within 90 minutes under sunlight, the Rifampicin decomposed efficiency of TiO2/Nd and TiO2/Nd/rice husk ash material reached about 86 and 75%, respectively. Even lower efficiency was obtained, the latter material was chosen for Rifampicin residue decomposition in the water under sunlight through photocatalytic process because it has some advantages such as smaller amount was needed and easily to be recovered. Rifampicin removal process, k values were found matching more to zero and first order kinetics. Especially, for powder TiO2/Nd and TiO2/Nd/Rice husk ash under solar irradiation the R2 reached about 0.98.
A Hybrid Optimization Algorithm for Enhanced Web Services with QoS Measures in Cloud Computing.
Authors: Thenmozhi L , Chandrakala N. 
Published: July 2021

Abstract
In the Environment of Big-Data analytics in world-wide, the cloud web-services were deployed in internet and Intranet domains. Moreover cloud computing possess the privileges and acquired rapid development, faces the trust complexities, privacy concepts and security issues which allows to implement the QoS measures in the optimization techniques in the web services selection. The study focusses on selection of component services and employing the efficient algorithm with end to end Quality of measures. The Data diversification and the service characteristics would decline the accuracy level of the measures. In this study a novel Qos measure web-services algorithm implemented the weight attributes and the subjective attributes. This study employs the novel hybrid-optimization algorithm in gaining the privileges of the search randomised-attributes and the implementation of IWO-invasive-weed algorithm. This study also focusses on the Calculation of Quality-of-service measures on the weights of the web-services attributes. Many researches have placed the Implementation of nature inspired concept for the optimization complexities in Big Data and thus employing Eagle-Perching Algorithm in the efficiency enhancement of cloud web-services. The evolution of BES- Bald Eagle-Search were utilized as the nature inspired approach would drive as the efficient technique for optimisation issues which imitates the bald-eagles behaviour. The results have been demonstrated the comparison of the performance metrics with the existing approaches to evaluate the proposed methodology.
New hydrogen atom model and radiation absorption mechanism
Authors: Wang Xiao En 
Published: July 2021

Abstract
Only Coulomb force is considered in Bohr model. It is found that electron in ground state hydrogen atom is also affected by Lorentz force of the same magnitude. Under the combined action of Coulomb force and Lorentz force, the radius of hydrogen atom is twice that of Bohr, and the rotation frequency of electron is half that of Bohr. The "half frequency" problem of Bohr's theory is solved, and the quantization result of the energy level of hydrogen atom is obtained by using the standing wave condition of quantum mechanics. The mechanism and details of photon absorption by hydrogen atom are analyzed and explained, and the physical meaning of Planck constant is explained.
A Novel Gene Expression Signature-Based on B-Cell Proportion to Predict Prognosis of Patients with Lung Adenocarcinoma
Authors: Yi Zhang , Xuewen Yin , Qi Wang , Xuming Song , Wenjie Xia , Qixing Mao , Bing Chen , Yingkuan Liang , Te Zhang , Lin Xu , Feng Jiang , Xinyu Xu , Gaochao Dong 
Published: July 2021

Abstract
Background: This study aimed to develop a reliable immune signature based on B-cell proportion to predict the prognosis and benefit of immunotherapy in LUAD.Methods: The proportion of immune cells in the TCGA-LUAD dataset was estimated using MCP-counter. The Least Absolute Shrinkage and Selector Operation was used to identify a prognostic signature and validated in an independent cohort. We used quantitative reverse transcription-polymerase chain reaction (qRT-PCR) data and formalin-fixed paraffin-embedded (FFPE) specimens immunohistochemistry to illustrate the correlation between prognostic signature and leukocyte migration. Results: We found that the relative abundance of B lineage positively correlated with overall survival. Then, we identified a 13-gene risk-score prognostic signature based on B lineage abundance in the testing cohort and validated it in a cohort from the GEO dataset. This model remained strongly predictive of prognoses across clinical subgroups. Further analysis revealed that patients with a low-risk score were characterized by B-cell activation and leukocyte migration, which was also confirmed in FFPE specimens by qRT-PCR and immunohistochemistry. Finally, this immune signature was an independent prognostic factor in the composite nomogram of clinical characteristics.Conclusions: In conclusion, the 13-gene immune signature based on B-cell proportion may serve as a powerful prognostic tool in LUAD.
Transcriptome Sequencing Reveals Gene Expression Differences in the Response of Malignant Melanomas Cells to Hypoxia
Authors: Xu Haiting , Liu Huazhen , Li Zi , Xu Qin , Lin Nan , Li Xiaoyang 
Published: July 2021

Abstract
BackgroundMalignant melanoma (MM) is the most deadly type of skin cancer, with 5-year survival rate of less than 16%. HIF-1α overexpression is associated with poor prognosis in many cancers including MM. Hence, we characterized differentially expressed genes (DEGs) in the response of MM cells to normal and hypoxia. MethodsWe first successfully constructed cell hypoxia model and then performed RNA-seq to explore the changes of gene transcription in MM cells during hypoxia. The highest expression of the six genes was detected using qRT-PCR and western blot assays. We explored the binding sites between BIRC7 promoter and HIF-1α by dual-luciferase assay. Cellular function assays were used to observe the role of BIRC7 in the effect of hypoxia on tumor progression. ResultsWe found that compared with the transcriptome data of the control group, a total of 2601 DEGs were identified in the hypoxic group. There were 1517 genes with significantly higher expression and 1084 genes with lower expression in the hypoxic group. Among them, OSCAR, BIRC7, HBA1, SFN, GOLT1A, and BEX2 were significantly up-regulated in the hypoxic group. BIRC7 expression was most significantly up-regulated and a downstream factor of HIF-1α. We highlighted that knockdown of BIRC7 reversed the positive effects of HIF-1α on A875 and M14 cells. ConclusionsOur findings demonstrated that BIRC7 was a downstream factor of HIF-1α and reversed the effect of hypoxia on promoting tumor progression of MM cells.
Resistin Levels and Inflammatory and Endothelial Dysfunction Markers in Obese Postmenopausal Women With Type 2 Diabetes Mellitus.
Authors: GIANDALIA Annalisa , Alibrandi Angela , Giorgianni Letterio , Piano Federico Lo , Consolo Francesca , Longo Giorgio Elia , Asztalos Bela , Cucinotta Domenico , Squadrito Giovanni , Russo Giuseppina 
Published: July 2021

Abstract
Background: Obesity- associated coronary heart disease (CHD) risk is higher in women than in men with type 2 diabetes (T2DM). Resistin, an adipokine secreted by adispose tissue, may contribute to this higher risk.Aims: To explore the relationships among resistin levels and common inflammatory and endothelial dysfunction markers and CHD risk in obese post-menopausal T2DM women.Methods: Serum levels of resistin, hsCRP, IL-6, Soluble vascular cell adhesion molecule (sVCAM), homocysteine (tHcy), HOMA-IR and metabolic parameters were determined in a group of 132 T2DM women with and without documented CHD and in 55 non-diabetic women.Results: Resistin, sVCAM, IL-6 and tHcy levels were comparable in T2DM and controls. CHD women showed higher resistin, sVCAM and tHcy levels than those without CHD, and for resistin this difference remained significant after age-adjustment (P=0.013); conversely hsCRP were ~2X higher in T2DM women than in controls (P=0.0132) without any difference according to CHD history.At univariate analysis resistin levels were significantly associated with age, waist circumference, hypertension, tHcy, hsPCR, sVCAM, IL-6, HDL-cholesterol, triglycerides and creatinine levels, but only creatinine, triglycerides, hsCRP, IL-6 and sVCAM were independent predictors of resistin levels at stepwise regression analysis.Resistin levels were independent predictors of CHD, increasing the risk by 1.15 times (0.986-1.344 95% CI), together with age, tHcy, LDL-C and hypertension. Conclusions: Circulating resistin levels were comparable in obese/overweight T2DM and control women. In T2DM women, resistin levels correlated with markers of renal function, systemic inflammation and endothelial dysfunction and were independently associated with a higher CHD risk.
Effect of Iron Supplementation On The Biogas Production and Microbial Community Distribution During Anaerobic Digestion of Food Waste Process
Authors: Xu Yue , Zhang Rongtang , Liu Jiesheng , He Xinghua , Lu Haijun , Wei Na , Zhang Jing 
Published: July 2021

Abstract
Iron as micronutrients is of great significance for forming a stable and efficient anaerobic digestion of food waste. Aim of this study was to examine the effect of iron supplementation on the mesophilic anaerobic digestion of food waste. Firstly, batch experiments were conducted with different iron concentration at a constant kitchen waste/inoculum ratio (K/I = 1.0), which indicated that the effect of iron on anaerobic digestion of was strictly dosage-dependent. Then, anaerobic digestion of food waste was conducted for 50 days in semi-continuous rectors with optimal iron concentration (2.0mg /L) under the same conditions. And the semi-continuous rectors obtained a good operation performance with low volatile fatty acids concentration, higher biogas production, high coenzyme F420 and dehydrogenase concentrations. Furthermore, two samples taken on 7th day and 50th day were analyzed by high-throughput sequencing, which illustrated that the composition anaerobe community was stable. However, the growth and activity of several syntrophic microbial groups (Aminobacterium, Syntrophomonas, Anaerolineaceae, Methanosaeta, Methanosarcina, Methanobacterium and Methanospirillum), were stimulated by iron supplementation. The shift of microbial community suggested that a high-efficiency microbial community for methane production from food waste was formed by iron supplementation.