bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID-19 Mitigation Efforts on Adults With Serious Mental Illness
Authors: Benjenk Ivy , Saliba Zeina , Duggal Neel , Albaroudi Asmaa , Posada Jacqueline , Chen Jie 
Published: June 2021

Abstract
In response to COVID-19 mitigation policies, mental health and social service agencies have had to rapidly change their operations, creating challenges for patients with serious mental illness (SMI). This study aimed to explore the experiences of adults with SMI navigating these altered systems during the pandemic. In-depth interviews were conducted with 20 hospitalized adults with SMI in the fall of 2020; they were coded using thematic analysis. Most participants found the new systems effective at meeting their essential needs. However, several reported significant unmet needs, including inability to access mental health care and public benefits. These participants lacked identification documents, housing, and/or a personal device. Although none of the participants used telemedicine before COVID-19, most reported no or minimal problems with telemental health. Those reporting difficulties did not have personal devices, were receiving audio-only services, or viewed telemedicine as less personal or too distracting.
Safety and Potency of COVIran Barekat Inactivated Vaccine Candidate for SARS-CoV-2: A Preclinical Study
Authors: Abdoli Asghar , Aalizadeh Reza , Aminianfar Hossein , Kianmehr Zahra , Azimi Ebrahim , Emamipour Nabbi , Jamshidi Hamidreza , Hosseinpour Mohammadreza , Taqavian Mohammad , Jalili Hasan 
Published: June 2021

AbstractThere is an urgent demand to manufacture an effective and safe vaccine to prevent SARS-CoV2 infection, which resulted in a global pandemic. In this study, we developed an inactivated whole-virus SARS-CoV-2 candidate vaccine named COVIran Barekat. Immunization at two different doses (3 µg or 5 µg per dose) elicited a high level of SARS-CoV-2 specific neutralizing antibodies in mice, rabbits, and non-human primates. The results show the safety profile in studied animals (include guinea pig, rabbit, mice, and monkeys). Rhesus macaques were immunized with the two-dose of 5 µg and 3 µg of the COVIran Barekat vaccine and showed highly efficient protection against 104 TCID50 of SARS-CoV-2 intratracheal challenge compared with the control group. These results highlight the COVIran Barekat vaccine as a potential candidate to induce a strong and potent immune response which may be a promising and feasible vaccine to protect against SARS-CoV2 infection.
Unraveling the functions of uncharacterized transcription factors inEscherichia coliusing ChIP-exo
Authors: Gao Ye , Lim Hyun Gyu , Verkler Hans , Szubin Richard , Quach Daniel , Rodionova Irina , Chen Ke , Yurkovich James T. , Cho Byung-Kwan , Palsson Bernhard O. 
Published: June 2021

AbstractBacteria regulate gene expression to adapt to changing environments through transcriptional regulatory networks (TRNs). Although extensively studied, no TRN is fully characterized since the identity and activity of all the transcriptional regulators that comprise a TRN are not known. Here, we experimentally evaluate 40 uncharacterized proteins inEscherichia coliK-12 MG1655, which were computationally predicted to be transcription factors (TFs). First, we used a multiplexed ChIP-exo assay to characterize genome-wide binding sites for these candidate TFs; 34 of them were found to be DNA-binding protein. We then compared the relative location between binding sites and RNA polymerase (RNAP). We found 48% (283/588) overlap between the TFs and RNAP. Finally, we used these data to infer potential functions for 10 of the 34 TFs with validated DNA binding sites and consensus binding motifs. These TFs were found to have various roles in regulating primary cellular processes inE. coli. Taken together, this study: (1) significantly expands the number of confirmed TFs, close to the estimated total of about 280 TFs; (2) predicts the putative functions of the newly discovered TFs, and (3) confirms the functions of representative TFs through mutant phenotypes.
Training transfer model as a possibility for the mandatory internship at sport science undergraduate courses
Authors: Silva Piovani Verónica Gabriela , Parra Barbosa Rinaldi Ieda , Both Jorge 
Published: June 2021

PurposeThis article aims to explain the transfer of training model used in the training of human resources within organizations and its possibilities for the mandatory internship (MI) in sport science (SS) higher education.Design/methodology/approachA review that argues the concept of transfer of learning, the model of factors that affect the transfer of training and its evolution was undertaken.FindingsThe possibilities and implications of thinking about the MI in the SS undergraduate courses are listed based on the transfer of learning and of training model. It is concluded that different factors such as the students' characteristics, the characteristics of the different spaces of SS professional's intervention, the evaluation, the academic and technical supervisors, the host organization and peers, as well as other elements of the transfer of training model, are important to develop the MI at the SS undergraduate courses.Originality/valueThe consideration of this model of factors could be relevant to improve the teaching and learning processes within the MI at the SS undergraduate courses.
Development of a behavioral taxonomy of agility in the workplace
Authors: Petermann Moritz Karl Herbert , Zacher Hannes 
Published: June 2021

PurposeThe concept of workforce agility has become increasingly popular in recent years. However, defining it has sparked much discussion and ambiguity. Recognizing this ambiguity, this paper aims to inductively develop a behavioral taxonomy of workforce agility.Design/methodology/approachThe authors interviewed 36 experts in the field of agility and used concept mapping and the critical incident technique to create a behavioral taxonomy.FindingsThe authors identified a behavioral taxonomy consisting of ten dimensions: (1) accepting changes, (2) decision making, (3) creating transparency, (4) collaboration, (5) reflection, (6) user centricity, (7) iteration, (8) testing, (9) self-organization, and (10) learning.Research limitations/implicationsThe authors’ research contributes to the literature in that it offers an inductively developed behavioral taxonomy of workforce agility with ten dimensions. It further adds to the literature by tying the notion of workforce agility to the performance literature.Practical implicationsThe authors’ results suggest that it might be beneficial for companies to take all workforce agility dimensions into account when creating an agile culture, starting agile projects, integrating agility into hiring decisions or evaluating employee performance.Originality/valueThis paper uses an inductive approach to define workforce agility as a set of behavioral dimensions, integrating the scientific as well as the practitioner literature on agility.
Determinants of e-commerce satisfaction: a comparative study between Romania and Moldova
Authors: Dospinescu Octavian , Dospinescu Nicoleta , Bostan Ionel 
Published: June 2021

PurposeThe purpose of this article is to highlight the relevance of the factors that influence the satisfaction of e-commerce consumers in Romania and Moldova. The study aims to clearly define the main influence factors, so that the marketing managers of the online stores can adopt scientific well-founded decisions.Design/methodology/approachThe paper opted for a study including a large sample of 399 respondents from two countries. For the analysis of the factors influencing the e-commerce satisfaction, multiple linear regression analysis was implemented, and their differentiation within the two countries was highlighted by multivariate analysis of variance.FindingsThe research conducted and the results obtained show that there is a differentiation of the factors that influence the level of satisfaction of e-commerce users in Romania and Moldova.Research limitations/implicationsThe research is still limited in terms of population studied to only two countries: Romania and Moldova. Although the study is intended to be exhaustive by analyzing no less than 11 factors influencing the satisfaction generated by e-commerce, it is still limited to this group of representative factors. Another limitation has to do with the limited number of demographic variables the authors have included.Practical implicationsBased on the results, the managerial implications for e-commerce companies that want to uniquely address consumers in Romania and Moldova are related to the decisions of marketing and sales managers who must allocate budgets and resources to improve the eight aspects highlighted in the paper. Also, the e-commerce companies should not allocate resources for the implementation of functionalities such as in-app after sales services, the possibility to cancel an order or the live consultant support feature, because these aspects do not influence the satisfaction of e-commerce consumers in Romania and Moldova.Originality/valueThis paper is the first in the scientific literature that implements a comparative study on the influence factors regarding the e-commerce satisfaction in Romania and Moldova. Also, it is important to mention that the present study is an exhaustive one because it includes many influence factors that were analyzed separately in the previous research papers from literature review.
Financial Hedging, Corporate Cash Policy, and the Value of Cash
Authors: Sun Wenyi , Yin Chao , Zeng Yeqin 
Published: June 2021

AbstractWe study the implications of financial hedging for corporate cash policy and the value of cash holdings. Using a web crawler program to collect data on the use of financial derivatives between 1993 and 2016, we find that US public firms with financial hedging programs have smaller cash reserves but a higher value of cash than firms without hedging contracts in place. Our empirical results are robust when controlling for potential endogeneity issues, corporate governance, cash regimes and alternative measures of cash holdings. Further, we find that financial hedging not only increases the investment sensitivity to internal cash, but also has a positive effect on investment efficiency. The positive effect of financial hedging on the value of cash is more pronounced for firms with more financial constraints, higher information asymmetry and weaker corporate governance. Collectively, our paper highlights the importance of corporate cash policy as a channel through which financial risk management increases firm value.
Effects of preserving the bronchial artery on cough after thoracoscopic lobectomy
Authors: Pan Liuying , Zhou Xiaofei , Xu Chun , Ding Cheng , Chen Jun , Zhu Xinyu , Zhao Jun , Li Chang 
Published: June 2021

AbstractBackgroundThe purpose of this prospective study was to explore the influence of both preoperative three‐dimensional (3D) reconstruction and intraoperative preservation of the bronchial artery (BA) on postoperative cough after thoracoscopic lobectomy.MethodsA total of 60 patients who had received a combination of thoracoscopic lobectomy and systematic lymph node dissection were included in this study. They were divided into two groups, namely the BA preservation group (Group A), and conventional surgical treatment group (Group B). In group A, we used Exoview software for 3D reconstruction of the BA before the operation and the BA was preserved during the operation. 3D reconstruction of the BA was not performed before surgery in group B. The incidence of postoperative cough, the Mandarin Chinese version of the Leicester cough questionnaire (LCQ‐MC), physiological, psychological and social dimensions and total score of the two groups were compared and analyzed.ResultsThe scores and total scores of LCQ‐MC in group B were lower than those in group A one and two months after surgery. There were significant differences between the two groups in physiological and psychological dimensions and total scores (p < 0.05), but there was no significant difference in social dimension between the two groups (p > 0.05). The incidence of postoperative cough in group A (16.7%) was lower than that in group B (30%), while the difference was not statistically significant (p = 0.222).ConclusionsPreoperative 3D reconstruction and intraoperative preservation of the BA can reduce the severity of postoperative cough.
Disturbance‐specific behavioral responses of giant otters exposed to ecotourism and extractive activities
Authors: Barocas A. , Farfan J. , Groenendijk J. , Mendoza J. , Silva J. , Mujica O. , Ochoa J. A. , Macdonald D. W. , Swaisgood R. R. 
Published: June 2021

AbstractHuman activities increasingly result in disturbance of wild animal populations. Behavioral responses vary according to the type, duration, frequency and intensity of disturbance. Exposure to disturbance, for example, arising from ecotourism, may promote tolerance of humans and drive a decrease in vigilance and avoidance behaviors, whereas disturbance resulting from extractive activities is typically more intense and is likely to be perceived as a threat. To understand how animals cope with land transformation and human presence, it is imperative to study their responses under different disturbance regimes. We performed behavioral sampling of groups of the giant otter, a charismatic top carnivore, exposed to ecotourism, extractive activities (mining and fishing) and control sites without disturbance to compare their responses. Foraging efficiency was impacted by fish abundance and thus was reduced in mined and fished areas. Giant otters in lakes with managed ecotourism did not show avoidance of research vessels and demonstrated reduced rates of defensive behavior compared to control lakes. Groups from lakes with fishing and gold mining showed increased avoidance, suggesting that these types of disturbance may involve more direct conflict. Our findings suggest that noninvasive disturbance such as ecotourism may promote giant otter tolerance to the presence of humans, whereas extractive activities may be perceived as riskier. Current protected area conservation strategies of strict ecotourism regulation and the maintenance of no‐access oxbow lakes may ensure the maintenance of behavioral flexibility in giant otter populations. However, resource depletion and more intense human‐giant otter interactions in disturbed areas may not be sustainable. Further studies are necessary to determine whether distinct disturbance regimes drive longer‐term demographic effects.
Successful management of treatment resistant nail psoriasis with tildrakizumab
Authors: Simpson Kate , Low Zhi Mei , Howard Anne , Kern Johannes S 
Published: June 2021

AbstractNail psoriasis significantly impacts quality of life and is notoriously difficult to treat. Tildrakizumab, an IL‐23 inhibitor, has shown significant clinical improvement in the treatment of moderate‐to‐severe chronic plaque psoriasis. We report 2 cases of treatment resistant nail psoriasis which showed marked improvement with the use of off‐label tildrakizumab. The dosing regimen utilised was consistent with that used to treat chronic plaque psoriasis, with 100 mg subcutaneously at Day 0 and Week 4, and maintenance dosing of 100 mg every 12 weeks thereafter. Significant improvement at 6 and 12 months, as per the modified Nail Psoriasis Severity Index (mNAPSI) and Dermatology Life Quality Index (DLQI), was seen. There have been no tildrakizumab related side effects observed to date. Tildrakizumab appears to be an effective option in managing treatment resistant nail psoriasis.
Advances in exosome therapies in ophthalmology–From bench to clinical trial
Authors: Sanghani Amisha , Andriesei Petru , Kafetzis Konstantinos N. , Tagalakis Aristides D. , Yu‐Wai‐Man Cynthia 
Published: June 2021

AbstractDuring the last decade, the fields of advanced and personalized therapeutics have been constantly evolving, utilizing novel techniques such as gene editing and RNA therapeutic approaches. However, the method of delivery and tissue specificity remain the main hurdles of these approaches. Exosomes are natural carriers of functional small RNAs and proteins, representing an area of increasing interest in the field of drug delivery. It has been demonstrated that the exosome cargo, especially miRNAs, is at least partially responsible for the therapeutic effects of exosomes. Exosomes deliver their luminal content to the recipient cells and can be used as vesicles for the therapeutic delivery of RNAs and proteins. Synthetic therapeutic drugs can also be encapsulated into exosomes as they have a hydrophilic core, which makes them suitable to carry water‐soluble drugs. In addition, engineered exosomes can display a variety of surface molecules, such as peptides, to target specific cells in tissues. The exosome properties present an added advantage to the targeted delivery of therapeutics, leading to increased efficacy and minimizing the adverse side effects. Furthermore, exosomes are natural nanoparticles found in all cell types and as a result, they do not elicit an immune response when administered. Exosomes have also demonstrated decreased long‐term accumulation in tissues and organs and thus carry a low risk of systemic toxicity. This review aims to discuss all the advances in exosome therapies in ophthalmology and to give insight into the challenges that would need to be overcome before exosome therapies can be translated into clinical practice.
Video games, frustration, violence, and virtual reality: Two studies
Authors: Ferguson Christopher J. , Gryshyna Anastasiia , Kim Jung Soo , Knowles Emma , Nadeem Zainab , Cardozo Izabela , Esser Carolin , Trebbi Victoria , Willis Emily 
Published: June 2021

The degree to which the content of video games influences aggression continues to be debated in the scholarly literature. The current article includes two studies, one of which replicates one study from Przybylski et al. (2014, J. Pers. Soc. Psychol., 106, 441) and the other which extends related concepts into virtual reality. In the first study, two versions of Tetris were examined, differing in levels of difficulty. In the second study, participants played virtual reality games which differed in regard to difficulty and violent content. Difficulty increased hostility in the second study but not the first. Violent content influenced neither hostility nor aggressive behaviour. Results partially supported the frustration theory of aggression, but not theories of violent content effects. Implications for the field are discussed.
Assessing conservation status with extensive but low‐resolution data: Application of frequentist and Bayesian models to endangered Athabasca River rainbow trout
Authors: Post John R. , Ward Hillary G. M. , Wilson Kyle L. , Sterling George L. , Cantin Ariane , Taylor Eric B. 
Published: June 2021

AbstractUse of extensive but low‐resolution abundance data is common in the assessment of species at‐risk status based on quantitative decline criteria under International Union for Conservation of Nature (IUCN) and national endangered species legislation. Such data can be problematic for 3 reasons. First, statistical power to reject the null hypothesis of no change is often low because of small sample size and high sampling uncertainty leading to a high frequency of type II errors. Second, range‐wide assessments composed of multiple site‐specific observations do not effectively weight site‐specific trends into global trends. Third, uncertainty in site‐specific temporal trends and relative abundance are not propagated at the appropriate spatial scale. A common result is the propensity to underestimate the magnitude of declines and therefore fail to identify the appropriate at‐risk status for a species. We used 3 statistical approaches, from simple to more complex, to estimate temporal decline rates for a designatable unit (DU) of rainbow trout in the Athabasca River watershed in western Canada. This DU is considered a native species for purposes of listing because of its genetic composition characterized as >0.95 indigenous origin in the face of continuing introgressive hybridization with introduced populations in the watershed. Analysis of abundance trends from 57 time series with a fixed‐effects model identified 33 sites with negative trends, but only 2 were statistically significant. By contrast, a hierarchical linear mixed model weighted by site‐specific abundance provided a DU‐wide decline estimate of 16.4% per year and a 3‐generation decline of 93.2%. A hierarchical Bayesian mixed model yielded a similar 3‐generation decline trend of 91.3% and the posterior distribution showed that the estimate had a >99% probability of exceeding thresholds for an endangered listing. We conclude that the Bayesian approach was the most useful because it provided a probabilistic statement of threshold exceedance in support of an at‐risk status recommendation.
Combat, casualties, and compensation: Evidence from Iraq and Afghanistan
Authors: Armey Laura , Kniesner Thomas J. , Leeth John D. , Sullivan Ryan 
Published: June 2021

AbstractOur research examines the effect of combat deployments to Iraq and Afghanistan on casualties and combat exposure compensation policy. We use restricted data from the Defense Manpower Data Center (DMDC) and Social Security Administration (SSA) to construct a panel of all US Active Duty service members having served at some point during the years 2001–2012. Casualties disproportionately occur at higher rates among (i) young, white, males, (ii) enlisted personnel, (iii) less educated personnel, and (iv) those in combat job types. Our estimates indicate that overall US military personnel who deployed in an individual year to Iraq or Afghanistan had a 45 per 100,000 higher probability of death than non‐deployed military personnel who remained stateside. The increased fatal injury risk of deployed US military personnel is 15 times higher than the national average civilian workplace fatality rate, but roughly equal to the fatal injury risk faced in some of the most dangerous civilian occupations. Our estimates suggest a compensating wage differential equal to $861 per month would be appropriate in comparison to the current average of $1238 per month in danger pay provided to US military personnel deployed into combat zones. We recommend a revenue‐neutral approach in adjusting the pay structure for military members. For example, the military should consider increasing bonuses or base pay while simultaneously decreasing danger pay by an equivalent amount. Furthermore, it may be beneficial to adjust danger pay by service or job type to reflect fatality risk more accurately.
The bias of growth opportunity
Authors: Gong Cynthia M. , Li Xindan , Luo Di , Zhao Huainan 
Published: June 2021

AbstractThe bias of growth opportunity (BGO), measured as the difference between market and fundamental values of a firm's growth opportunity, has an ability to predict future stock returns. In the portfolio sort, downward‐biased BGO firms earn higher returns than upward‐biased ones, which is unexplained by the common asset pricing models. Cross‐sectional regression results also confirm BGO's power in predicting stock returns. To explain the anomaly, we show that the BGO premium is more pronounced when investor sentiment is high or when limits‐to‐arbitrage is severe, which suggests that the is more likely to capture behavioural biases than systematic risk.