bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gas conditioning during helmet noninvasive ventilation: effect on comfort, gas exchange, inspiratory effort, transpulmonary pressure and patient–ventilator interaction
Authors: Bongiovanni Filippo , Grieco Domenico Luca , Anzellotti Gian Marco , Menga Luca Salvatore , Michi Teresa , Cesarano Melania , Raggi Valeria , De Bartolomeo Cecilia , Mura Benedetta , Mercurio Giovanna , D’Arrigo Sonia , Bello Giuseppe , Maviglia Riccardo , Pennisi Mariano Alberto , Antonelli Massimo 
Published: December 2021

AbstractBackgroundThere is growing interest towards the use of helmet noninvasive ventilation (NIV) for the management of acute hypoxemic respiratory failure. Gas conditioning through heat and moisture exchangers (HME) or heated humidifiers (HHs) is needed during facemask NIV to provide a minimum level of humidity in the inspired gas (15 mg H2O/L). The optimal gas conditioning strategy during helmet NIV remains to be established.MethodsTwenty patients with acute hypoxemic respiratory failure (PaO2/FiO2 < 300 mmHg) underwent consecutive 1-h periods of helmet NIV (PEEP 12 cmH2O, pressure support 12 cmH2O) with four humidification settings, applied in a random order: double-tube circuit with HHs and temperature set at 34 °C (HH34) and 37 °C (HH37); Y-piece circuit with HME; double-tube circuit with no humidification (NoH). Temperature and humidity of inhaled gas were measured through a capacitive hygrometer. Arterial blood gases, discomfort and dyspnea through visual analog scales (VAS), esophageal pressure swings (ΔPES) and simplified pressure–time product (PTPES), dynamic transpulmonary driving pressure (ΔPL) and asynchrony index were measured in each step.ResultsMedian [IqR] absolute humidity, temperature and VAS discomfort were significantly lower during NoH vs. HME, HH34 and HH37: absolute humidity (mgH2O/L) 16 [12–19] vs. 28 [23–31] vs. 28 [24–31] vs. 33 [29–38],p < 0.001; temperature (°C) 29 [28–30] vs. 30 [29–31] vs. 31 [29–32] vs 32. [31–33],p < 0.001; VAS discomfort 4 [2–6] vs. 6 [2–7] vs. 7 [4–8] vs. 8 [4–10],p = 0.03. VAS discomfort increased with higher absolute humidity (p < 0.01) and temperature (p = 0.007). Higher VAS discomfort was associated with increased VAS dyspnea (p = 0.001). Arterial blood gases, respiratory rate, ΔPES, PTPESand ΔPLwere similar in all conditions. Overall asynchrony index was similar in all steps, but autotriggering rate was lower during NoH and HME (p = 0.03).ConclusionsDuring 1-h sessions of helmet NIV in patients with hypoxemic respiratory failure, a double-tube circuit with no humidification allowed adequate conditioning of inspired gas, optimized comfort and improved patient–ventilator interaction. Use of HHs or HME in this setting resulted in increased discomfort due to excessive heat and humidity in the interface, which was associated with more intense dyspnea.Trail RegistrationRegistered on clinicaltrials.gov (NCT02875379) on August 23rd, 2016.
Next generation earth-to-space telecommand coding and synchronization: ground system design, optimization and software implementation
Authors: Abelló Ricard , Baldi Marco , Carvalho Filipe , Chiaraluce Franco , Fernandes Ricardo , Garello Roberto , Paolini Enrico , Prata Ricardo 
Published: December 2021

AbstractThe Consultative Committee for Space Data Systems, followed by all national and international space agencies, has updated the Telecommand Coding and Synchronization sublayer to introduce new powerful low-density parity-check (LDPC) codes. Their large coding gains significantly improve the system performance and allow new Telecommand services and profiles with higher bit rates and volumes. In this paper, we focus on the Telecommand transmitter implementation in the Ground Station baseband segment. First, we discuss the most important blocks and we focus on the most critical one, i.e., the LDPC encoder. We present and analyze two techniques, one based on a Shift Register Adder Accumulator and the other on Winograd convolution both exploiting the block circulant nature of the LDPC matrix. We show that these techniques provide a significant complexity reduction with respect to the usual encoder mapping, thus allowing to obtain high uplink bit rates. We then discuss the choice of a proper hardware or software platform, and we show that a Central Processing Unit-based software solution is able to achieve the high bit rates requested by the new Telecommand applications. Finally, we present the results of a set of tests on the real-time software implementation of the new system, comparing the performance achievable with the different encoding options.
IRF4 expression is low in Philadelphia negative myeloproliferative neoplasms and is associated with a worse prognosis
Authors: Cumbo Cosimo , Tarantini Francesco , Anelli Luisa , Zagaria Antonella , Redavid Immacolata , Minervini Crescenzio Francesco , Coccaro Nicoletta , Tota Giuseppina , Ricco Alessandra , Parciante Elisa , Conserva Maria Rosa , Specchia Giorgina , Musto Pellegrino , Albano Francesco 
Published: December 2021

AbstractInterferon regulatory factor 4 (IRF4) is involved in the pathogenesis of various hematologic malignancies. Its expression has been related to the negative regulation of myeloid-derived suppressor cells (MDSCs) and the polarization of anti-inflammatory M2 macrophages, thereby altering immunosurveillance and inflammatory mechanisms. An abnormal inflammatory status in the bone marrow microenvironment of myeloproliferative neoplasms (MPNs) has recently been demonstrated; moreover, in chronic myeloid leukemia a downregulated expression of IRF4 has been found. In this context, we evaluated the IRF4 expression in 119 newly diagnosed consecutive Philadelphia negative MPNs (Ph- MPNs), showing a low expression among the MPNs phenotypes with a more significant decrease in primary myelofibrosis patients. Lower IRF4 levels were associated with JAK2 + and triple negatives cases carrying the worst prognosis. Furthermore, the IRF4 levels were related to leukemic transformation and a shorter leukemia-free survival; moreover, the risk of myelofibrosis transformation in polycythemia vera and essential thrombocythemia patients was more frequent in cases with lower IRF4 levels. Overall, our study demonstrates an IRF4 dysregulated expression in MPNs patients and its association with a worse prognosis. Further studies could validate these data, to improve our knowledge of the MPNs pathogenesis and confirm the IRF4 role as a new prognostic factor.
Research as an essentiality beyond one’s own competence: an interview study on frail older people's view of research
Authors: Haak Maria , Ivanoff Synneve , Barenfeld Emmelie , Berge Isak , Lood Qarin 
Published: December 2021

AbstractBackgroundThere is an increased interest to make the voices of frail older people heard in research by actively involving them in research processes. Involving frail older people in research could, however, be perceived as challenging by researchers. To actively involve frail older people in research processes in a meaningful way, the knowledge about their own views on what research is must be widened and deepened.MethodsIndividual interviews were conducted with 17 frail older men and women with former experience of participation in research studies. Qualitative data were analysed using content analysis.ResultsFrail older people’s views on what research means are described through the main category;An essentiality beyond one’s own competence,which describes research as a complex process that is important for society but difficult to understand. This is described in the sub-categories;A driving force for societal development, A benefit when based on lived experience, A source of knowledge difficult to access and understand,andA respected job filled with responsibilities.ConclusionDifferent views on research from the perspective of frail older people show that research is viewed as a complex yet important phenomenon to frail older people. Research was also seen as a natural part in society. Research was viewed as difficult to access and understand. Thus, researchers must train themselves to communicate research findings to the public in an understandable way. To create common understandings through information and education, researchers might be better placed to involve frail older people in a meaningful way and thereby also have the possibility to develop good working practice and relationships with those involved.
Psychometric validation and meaningful change thresholds of the Worst Itching Intensity Numerical Rating Scale for assessing itch in patients with chronic kidney disease-associated pruritus
Authors: Vernon Margaret K. , Swett Laura L. , Speck Rebecca M. , Munera Catherine , Spencer Robert H. , Wen Warren , Menzaghi Frédérique 
Published: December 2021

Abstract
Background
Chronic kidney disease-associated pruritus (CKD-aP) is characterized by persistent itch that often leads to substantially impaired quality of life. The Worst Itching Intensity Numerical Rating Scale (WI-NRS) is a single-item patient-reported outcome measure in which patients indicate the intensity of the worst itching they experienced over the past 24 h. Here, we evaluated the content validity and psychometric properties of the WI-NRS and confirmed the threshold of meaningful change in hemodialysis patients with moderate-to-severe CKD-aP.

Methods
Content validity interviews were conducted in 23 patients. Psychometric properties of the WI-NRS were assessed using data from one phase 2 (N = 174) and two phase 3 (N = 848) clinical trials investigating an anti-pruritic treatment. Anchor-based methods were used to confirm meaningful within-patient change score thresholds in the phase 3 trial patients and mixed-method exit interviews (N = 70) contributed further insight.

Results
Content validity interviews indicated patients considered the WI-NRS to be straightforward, comprehensive, and relevant. Test–retest reliability was strong in both trial cohorts (intraclass correlation coefficients > 0.75). Construct validity analyses indicated high correlation between the WI-NRS and other measures of itch. Anchor-based analyses showed a reduction of ≥ 3 points from baseline score represented an appropriate clinically meaningful within-patient change on the WI-NRS. In the exit interviews, all patients with a reduction ≥ 3 points considered the change meaningful.

Conclusions
The WI-NRS is a reliable, valid, and responsive measure of itch intensity for patients with moderate-to-severe CKD-aP. These results support its use to assess treatment efficacy and in clinical evaluation and management of pruritus in hemodialysis patients.
Socio demographic, clinical, and side effect profile of patients on clozapine in Kashmir, North India
Authors: Nazir Deeba , Wani Zaid Ahmad , Bukhari Fahd , Dar Shabir Ahmad , Kawoosa Yuman 
Published: December 2021

Abstract
Background
Clozapine is an atypical second-generation antipsychotic belonging to the family of dibenzodiazepines. There is lack of literature on clozapine from this part of the world. So, our aim was to study the socio demographic, clinical and side effect profile of patients on clozapine in Kashmir.

Results
The mean age of the study group was 32.6 ± 8.9 years with majority being males (78.4%), unmarried (78.4%), unemployed (77.2%), and belonging to nuclear families (77.2%). Almost half of them resided in urban localities (51.1%) and studied upto middle school (55.7%). Around three- fourth (75%) of the patients had diagnosis of treatment-resistant schizophrenia. The mean dose of clozapine was 338.92 ± 158.11 mgs. Sedation (76.1%), hypersalivation (69.5%), constipation (46.6%), and weight gain (34.1%) were most common side effects noted in patients. 4.5% cases developed seizures while on clozapine. 2.3% patients developed agranulocytosis while 4.5% patients developed neutropenia on clozapine. The neutropenia was more pronounced in patients of schizophrenia with suicidal tendencies with doses of more than 400 mg.

Conclusions
We have used clozapine in a wide range of indications. Our patients seem to tolerate and respond to higher doses of clozapine and the prevalence of blood dyscrasias in our study sample was much higher than the rest of India.
Molecular mechanisms of embryonic tail development in the self-fertilizing mangrove killifish Kryptolebias marmoratus
Authors: Saud Hussein A. , O'Neill Paul A. , Ono Yosuke , Verbruggen Bas , Van Aerle Ronny , Kim Jaebum , Lee Jae-Seong , Ring Brian C. , Kudoh Tetsuhiro 
Published: December 2021

ABSTRACT
Using the self-fertilizing mangrove killifish, we characterized two mutants, shorttail (stl) and balltail (btl). These mutants showed abnormalities in the posterior notochord and muscle development. Taking advantage of a highly inbred isogenic strain of the species, we rapidly identified the mutated genes, noto and msgn1 in the stl and btl mutants, respectively, using a single lane of RNA sequencing without the need of a reference genome or genetic mapping techniques. Next, we confirmed a conserved morphant phenotype in medaka and demonstrate a crucial role of noto and msgn1 in cell sorting between the axial and paraxial part of the tail mesoderm. This novel system could substantially accelerate future small-scale forward-genetic screening and identification of mutations. Therefore, the mangrove killifish could be used as a complementary system alongside existing models for future molecular genetic studies.
Screening, diagnosis and genetic study of breast cancer patients in Pakistan
Authors: Majeed Ayesha Isani , Ullah Asmat , Jadoon Muniba , Ahmad Wasim , Riazuddin Sheikh 
Published: December 2021

Objective: To determine the role of variants in BRCA1 gene in breast cancer development, women of Pakistani origin, diagnosed with breast cancer, were screened for variants in the BRCA1.
Methods: The present study involved screening of 5000 women for breast cancer. 302 women were diagnosed with breast cancer. Using Sanger sequencing, DNA extracted from peripheral blood of 100 patients was screened for disease causing variants in the BRCA1.
Results: Analysis of sequenced data revealed two frame shift (Gly312Trpfs*8, Ala322Glyfs*4), six missense (p.Glu362Lys, p.Lys651Arg, p.Asp693Asn, p.Pro871Leu, p.Glu1134Lys, p.Lys1183Arg), four synonymous (p.Thr327Thr, p.Ser694Ser, p.His771His, p.Gln1135Gln), and two intronic variants (g.75407T>C, g.75401_75401delT) in the patients.
Conclusion: The present investigation showed that variations in BRCA1 made substantial contribution in causing hereditary/early-onset breast cancer in Pakistani women.
doi: https://doi.org/10.12669/pjms.36.2.1059
How to cite this:Majeed AI, Ullah A, Jadoon M, Ahmad W, Riazuddin S. Screening, diagnosis and genetic study of breast cancer patients in Pakistan. Pak J Med Sci. 2020;36(2):16-20. doi: https://doi.org/10.12669/pjms.36.2.1059
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Magnesium Sulfate in combination with Nifedipine in the treatment of Pregnancy-Induced Hypertension
Authors: Xiang Cuiping , Zhou Xuegui , Zheng Xiaoxia 
Published: December 2021

Objective: To investigate the effect of magnesium sulfate combined with nifedipine in the treatment of pregnancy-induced hypertension syndrome (PIHS).
Methods: Total 118 pregnant women with PIHS who were admitted to our hospital from April 2017 to June 2018 were randomly divided into control group (59 cases) and observation group (59 cases). The observation group was treated by magnesium sulfate in combination with nifedipine, while the control group was treated by magnesium sulfate. The therapeutic effect, serum leukaemia inhibitory factor (LIF), Apelin level, blood pressure, blood viscosity, urinary protein, S/D and Umbilical Artery Resistance Index (UARI) were compared between the two groups.
Results: The effective rate of the observation group was 94.9%, higher than 83.1% of the control group, and the difference was statistically significant (P<0.05). The decrease level of systolic and diastolic blood pressure in the observation group was better than that in the control group, and the difference was statistically significant (P<0.05). The decrease of blood viscosity, urinary protein, S/D and UARI in the observation group was greater than that in the control group, and the difference was statistically significant (P<0.05). The improvement of serum LIF and Apelin levels in the observation group was better than that in the control group (P<0.05), and the difference was statistically significant (P<0.05).
Conclusion: Magnesium sulfate combined with nifedipine in the treatment of PIHS has a significant effect, which can effectively control edema, blood pressure, proteinuria and protect kidney. It is worth clinical promotion.
doi: https://doi.org/10.12669/pjms.36.2.706
How to cite this:Xiang C, Zhou X, Zheng X. Magnesium Sulfate in combination with Nifedipine in the treatment of Pregnancy-Induced Hypertension. Pak J Med Sci. 2020;36(2):21-25. doi: https://doi.org/10.12669/pjms.36.2.706
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A systematic review protocol of quantitative instruments of income inequality in studies of children and adolescents
Authors: O Driscoll David , Kiely Elizabeth , O Keeffe Linda , Khashan Ali 
Published: December 2021

Background: Income inequality is an important indicator of socioeconomic position which is a determinant of social, psychological, and physical health outcomes from childhood to adulthood. Different income inequality instruments (metrics) are used to investigate associations between income inequality and health outcomes (e.g. Gini coefficient, Theil Index). Income inequality instruments provide unique information on the construct of socioeconomic inequality. Albeit there is variation in studies as to the type and rationale for using a particular quantitative instrument of income inequality. The aim of this systematic review will investigate and identify the most used quantitative income inequality instrument in studies of children and adolescents Methods: The PRISMA-P framework will be applied to identify high quality articles (PROSPERO: CRD42021259114). A search will be conducted in PubMed, Embase, and PsycINFO. The search will include studies concerned with income inequality and/or socioeconomic inequality in children and adolescents. All articles will be independently reviewed, data extracted, and quality appraised by two reviewers and a third to arbitrate disputes. Articles will be initially reviewed by title and abstract using inclusion criteria. A data extraction form will be used. Three questions will be answered on the quality of the rationale for using a particular income inequality instrument and the Newcastle-Ottawa Scale will be used to assess bias and quality. The primary outcome of interest is the type and frequency of quantitative income inequality instrument used and the study outcome associated with that income inequality instrument. Conclusions: This systematic review will aim to explore and provide a summary of the different types of quantitative income inequality instruments used in studies of child and adolescent populations. This will help to guide researchers and policy makers on the inclusion and use of income inequality metrics in future studies aimed at understanding associations with health and social outcomes in children and adolescents.
Кореферентные структуры, используемые для представления экономических субъектов в медийном дискурсе
Authors: Ключенович Сергей 
Published: December 2021

The subject of study in the article is the discourse specifics of representation of economic entities in German newspaper and magazine texts of the last two decades. The purpose of the analysis is to elucidate the factors that stimulate univerbation in connection with the generation and textual integration of co-referential structures different in genesis, structural properties, semantic characteristics and stylistic potential.
The study, conducted on the basis of a functional-communicative approach to language, relies on methods and results of studies on text linguistics considering text as a whole structural-semantic unit.
Conclusions. 1) Mentioning of a company name is accompanied by integration of the univerb indicating the relevant industry into the text. Along with a two-member chain of co-referential nominations, a three-member chain is also possible (the location of a company is mentioned). 2) Co-referential pairs of the type “company name ‒ collective designation of employees according to headquarters location” (Siemens ‒ Münchener) are characteristic, which demonstrates the lability of univerb toponym semantics. 3) The integration of a proper name into the text requires the usage of characterizing common nouns in order to prepare the reader for the perception of unique names, which is a factor motivating univerbation. 4) Synthetic compounds of the nomina agentis type (Autobauer, Stromversorger) are widely used to describe the kind of activity of an enterprise. In such cases a lexeme with the expected semantics is eliminated (Unternehmen ‘company’, Konzern ‘concern’ etc.). The reduction of the base lexeme of a compound as well as representation of the verb lexeme in the form of nomen agentis has an impact on the semantics and stylistics of the univerb.
The results of the study can be used both in research activities on problems of word-formation, semantics and in the training of business translators.
Northern Regions of Russia as Described by the Flemish Knight de Lannoy: "Non-Muscovite" Identity
Authors: Kozulin V.N. 
Published: December 2021

The article deals with a unique work of Rossica, the first in Western Europe detailed description of the northern Russian regions of Novgorod and Pskov, written by an eyewitness. Memoirs of the Flemish knight, which contain this description, have been known for a long time and have been repeatedly researched. But in the context of the regional imagology of Russia they are considered for the first time. The relevance of the problem is also related to the importance of the study of francophone Rossica, which has not yet been sufficiently studied, for imagology and the history of intercultural interaction.
The memoirs are valuable because they represent the only work describing these regions even before they were part of the Muscovite principality, and thus the "non-Muscovite" identity of their population is clearly visible. Despite considerable cultural and socio-political similarities between the regions, the observer knight notes well the specificity of each of them separately.
The question is raised that the “muscovite identity” was secondary and by no means the only one in the descriptions of the “Russian character” and Russian state in European Rossica, and that the earliest sources describe just a different alternative identity, apparently especially relevant for the northern regions and closer to the European than to the “Muscovite” identity. It is also concluded that it is necessary to attract more attention to the historical experience of these regions in the teaching of history and in the formation of the historical memory of contemporary Russians.