bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mycophenolate mofetil‐induced peripheral neuropathy in the treatment of membranous glomerulonephropathy: A case report
Authors: Moghimi Minoo , Nekoukar Zahra , Gholami Farhad 
Published: December 2021

AbstractMycophenolate mofetil (MMF) as an immunosuppressive agent is widely used in the management of Membranous Glomerulonephropathy (MGN). In this report, we described a 66‐year‐old male MGN case treated with MMF and revealed acquired sensory‐motor axonal polyneuropathy, which is rare and has not been reported before.
A rare presentation of an ACTH‐producing high‐grade large cell neuroendocrine carcinoma with Cushing’s syndrome
Authors: Essien Francis , Persaud Christine , Dado David , Eden Rina , Tate Joshua , Shahin George 
Published: December 2021

AbstractHigh‐grade neuroendocrine tumors (HGNET) are rare neoplasms composed of neural and hormonal with only around 42 cases reported in the last 20 years1. Herein, we describe a rare case of pancreatic HGNET, large cell type, associated with a Cushing's syndrome presentation.
Fitz‐Hugh‐Curtis syndrome without salpingitis: Should contrast‐enhanced computed tomography be a routine diagnostic procedure?
Authors: Harada Taku , Shimizu Taro 
Published: December 2021

AbstractFitz‐Hugh‐Curtis syndrome should be suspected in sexually active young women presenting with acute right upper quadrant pain even in the absence of lower abdominal pain. The risk of radiation exposure associated with computed tomography should also be considered while making a diagnosis of abdominal pain in young patients.
Bilateral complex lactating adenosis: Clinical presentation and management in Sudan
Authors: Dafaalla Hatoun , Khougali Hussam S. , Malassi Yussra 
Published: December 2021

AbstractLactating adenosis is a benign breast neoplasm usually seen during pregnancy and lactation. We present a rare case of bilateral complex benign lactating adenosis in 19‐year‐old female patient presented with lactating adenosis that mimics cancer growth after giving birth. Histopathology confirmed diagnosis. Simple mastectomy was the treatment of choice.
Acute thyroid swelling with severe hypothyroid myxoedema after COVID‐19 vaccination
Authors: Giusti Massimo , Maio Agostino 
Published: December 2021

AbstractThe SARS‐CoV‐2 virus can trigger thyroid dysfunction. Thyroid dysfunctions after COVID‐19 vaccination have been rarely reported. We report the case of overt hypothyroidism in a 61‐year‐old woman seen after BNT162b2‐mRNA vaccination. This case underlines the fact that thyroid function should also be monitored after COVID‐19 vaccination, especially in at‐risk subjects.
Ureidosulfocoumarin Derivatives As Selective and Potent Carbonic Anhydrase IX and XII Inhibitors
Authors: Singh Priti , Kumar Sigalapalli Dilep , Sridhar Goud Nerella , Swain Baijayantimala , Kumar Sahoo Santosh , Angeli Andrea , Shaik Afzal B. , Madhavi Yaddanapudi Venkata , Supuran Claudiu T. , Arifuddin Mohammed 
Published: December 2021

AbstractOwing to severe allergic reactions (anaphylaxis) and resistance exhibited by sulfonamide‐based carbonic anhydrase (CA) inhibitors, non‐classical or non‐sulfonamide CA inhibitors are gaining increased attention by medicinal chemists. In this context, we report the design and synthesis of 30 new non‐sulfonamide sulfocoumarin derivatives as CA inhibitors. They were investigated against hCA I and II (cytosolic isozymes) as well as hCA IX and XII (transmembrane, tumor‐associated enzymes). All compounds showed prominent selectivity for the tumor‐associated isoenzymes hCA IX and XII over the cytosolic isoenzymes hCA I and II. Among all synthesized compounds, 1‐(2,2‐dioxidobenzo[e][1,2]oxathiin‐6‐yl)‐3‐(o‐tolyl)urea(5 j)and1‐(3‐fluorophenyl)‐3‐(8‐methoxy‐2,2‐dioxidobenzo[e][1,2]oxathiin‐6‐yl)urea(5 q)were found to be more potent and to have better inhibition constant values against hCA IX than the standard acetazolamide (AAZ), with Ki values of 23.6 and 23.3 nM, respectively. All other compounds were found to be active under Ki=920 nM against hCA IX and XII.This study provides a new perspective for the future development of non‐sulfonamide derivatives as selective CA inhibitors.
Modeling and simulation of defense game model for jamming attack in wireless sensor networks using evolutionary game theory
Authors: K Mohaideen Pitchai 
Published: December 2021

AbstractThe open and shared communication medium of wireless sensor networks creates vulnerability to various types of attacks. In particular, jamming is a kind of attack that is difficult to defend. When the jammer transmits the jamming signal, the nodes covered by the jamming signal will suffer for their transmission. The interactions between the jammer and the source nodes are complex. Thus this article models the interactions between the jammer and the source node as an evolutionary game‐theoretical model. The game model of jamming is formulated, and then the evolutionary analysis of the game model is done. The game model is solved using replicator dynamics, and also the solution is verified by conducting various simulations. It can also be verified by using a stability diagram of replicator dynamics. The equilibrium points are analyzed to check whether that is an evolutionarily stable strategy. Extensive numerical simulation experiments have been carried out to analyze the evolution of strategies for source nodes and jammer nodes.
Anion‐Dependent Outstanding Luminescence Enhancement of Eu(D‐facam)3 Upon Coexistence With the Tetramethylammonium Cation
Authors: Li Ziying , Minami Haruki , Nakamura Kazuki , Kobayashi Norihisa 
Published: December 2021

AbstractThe front cover artwork is provided by the group of Norihisa Kobayashi and Kazuki Nakamura at Chiba University. The image shows the drastic luminescence enhancement and induced circular polarization of Eu(D‐facam)3 in the presence of tetramethylammonium acetate. Read the full text of the Article at 10.1002/cphc.202100609.
METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control
Authors: Chen Zhihang , Zhu Wanjie , Zhu Shenghua , Sun Kaiyu , Liao Junbin , Liu Haining , Dai Zihao , Han Hui , Ren Xuxin , Yang Qingxia , Zheng Siyi , Peng Baogang , Peng Sui , Kuang Ming , Lin Shuibin 
Published: December 2021

AbstractBackgroundN7‐methylguanosine (m7G) modification is one of the most common transfer RNA (tRNA) modifications in humans. The precise function and molecular mechanism of m7G tRNA modification in hepatocellular carcinoma (HCC) remain poorly understood.MethodsThe prognostic value and expression level of m7G tRNA methyltransferase complex components methyltransferase‐like protein‐1 (METTL1) and WD repeat domain 4 (WDR4) in HCC were evaluated using clinical samples and TCGA data. The biological functions and mechanisms of m7G tRNA modification in HCC progression were studied in vitro and in vivo using cell culture, xenograft model, knockin and knockout mouse models. The m7G reduction and cleavage sequencing (TRAC‐seq), polysome profiling and polyribosome‐associated mRNA sequencing methods were used to study the levels of m7G tRNA modification, tRNA expression and mRNA translation efficiency.ResultsThe levels of METTL1 and WDR4 are elevated in HCC and associated with advanced tumour stages and poor patient survival. Functionally, silencing METTL1 or WDR4 inhibits HCC cell proliferation, migration and invasion, while forced expression of wild‐type METTL1 but not its catalytic dead mutant promotes HCC progression. Knockdown of METTL1 reduces m7G tRNA modification and decreases m7G‐modified tRNA expression in HCC cells. Mechanistically, METTL1‐mediated tRNA m7G modification promotes the translation of target mRNAs with higher frequencies of m7G‐related codons. Furthermore, in vivo studies with Mettl1 knockin and conditional knockout mice reveal the essential physiological function of Mettl1 in hepatocarcinogenesis using hydrodynamics transfection HCC model.ConclusionsOur work reveals new insights into the role of the misregulated tRNA modifications in liver cancer and provides molecular basis for HCC diagnosis and treatment.
In a search of a protective titer: Do we or do we not need to know?
Authors: Baranova Ancha , Chandhoke Vikas , Makarova Alena V. , Veytsman Boris 
Published: December 2021

AbstractThe level of postvaccine protection depends on two factors: antibodies and T‐cell responses. While the first one is relatively easily measured, the measuring of the second one is a difficult problem. The recent studies indicate that the first one may be a good proxy for the protection, at least for SARS‐CoV‐2. The massive data currently gathered by both researcher and citizen scientists may be pivotal in confirming this observation, and the collective body of evidence is growing daily. This leads to an acceptance of IgG antibody levels as an accessible biomarker of individual's protection. With enormous and immediate need for assessing patient condition at the point of care, quantitative antibody analysis remains the most effective and efficient way to assess the protection against the disease. Let us not discount importance of reference points in the turmoil of current pandemics.
Can single cell RNA sequencing reshape the clinical biochemistry of hematology: New clusters of circulating blood cells
Authors: Fang Hao , Zeng Yiming , Zhang Lianzhong , Chen Chengshui , Powell Charles A , Wang Xiangdong 
Published: December 2021

AbstractscRNA‐seq is on track for use as a routine measurement of clinical biochemistry and to assist in clinical decision‐making and guide the performance of molecular medicine, but there are still a large number of challenges to be overcome. In conclusion, scRNA‐seq‐based clusters and differentiation of circulating blood cells have been examined and informative in patients with various diseases, although the information generated from scRNA‐seq varies between different conditions, technologies, and diseases. Most of the clinical studies published have focused on the landscape of circulating immune cells, disease‐specific patterns of new clusters, understanding of potential mechanisms, and potential correlation between cell clusters, differentiations, cell interactions, and circulating and migrated cells. It is clear that the information from scRNA‐seq advances the understanding of the disease, identifies disease‐specific target panels, and suggests new therapeutic strategies. The adaptation of scRNA‐seq as a routine clinical measurement will require standardization and normalization of scRNA‐seq‐based comprehensive information and validation in a large population of healthy and diseased patients. The integration of public databases on human circulating cell clusters and differentiations with an application of artificial intelligence and computational science will accelerate the application of scRNA‐seq for clinical practice. Thus, we call special attention from scientists and clinicians to the clinical and translational discovery, validation, and medicine opportunities of scRNA‐seq development.
Abnormal B‐lymphoblasts in myelodysplastic syndromes and myeloproliferative neoplasms other than chronic myeloid leukemia
Authors: Chan Alexander , Kumar Priyadarshini , Gao Qi , Baik Jeeyeon , Sigler Allison , Londono Dory , Liu Ying , Arcila Maria E. , Dogan Ahmet , Zhang Yanming , Roshal Mikhail , Xiao Wenbin 
Published: December 2021

AbstractBackgroundLineage infidelity is characteristic of mixed phenotype acute leukemia and is also seen in blast phase of chronic myeloid leukemia (CML), myeloid/lymphoid neoplasia with eosinophilia and gene rearrangements, and subtypes of acute myeloid leukemia. Driver genetic events often occur in multipotent progenitor cells in myeloid neoplasms, suggesting that multilineage output may be more common than appreciated. This phenomenon is not well studied in myelodysplastic syndrome (MDS) and non‐CML myeloproliferative neoplasms (MPN).MethodsWe systematically evaluated phenotypic lineage infidelity by reviewing bone marrow pathology and flow cytometry (FC) studies of 1262 consecutive patients with a diagnosis of MDS and/or non‐CML MPN. We assessed B‐ and T‐cells in these patients by FC. When abnormal B‐lymphoblast (ABLB) populations were detected, we additionally evaluated immature B‐cells using a high sensitivity FC assay for B‐lymphoblastic leukemia/lymphoma (B‐ALL).ResultsWe identified 9 patients (7 MDS, 7/713, 1%; 2 non‐CML MPN, 2/312, 0.6%; 0 in MDS/MPN) with low‐level ABLB populations (0.012%–3.6% of WBCs in marrow) with abnormal immunophenotypes. Genetic studies on flow sorted cell populations confirmed that some ABLB populations were clonally related to myeloid blasts (4/6, 67%). On follow‐up, ABLB populations in 8/9 patients remained stable or disappeared. Only 1 case progressed to B‐ALL.ConclusionsThese findings demonstrate that phenotypically detectable abnormal immature B lineage output occurs in MDS and non‐CML MPN, albeit rarely. While presence of ABLB does not necessarily reflect blast crisis, the underlying disease biology of our findings may ultimately be relevant to patient management and warrants further investigation.
Defining the specificity of recombinant human erythropoietin confirmation in equine samples by liquid chromatography‐tandem mass spectrometry
Authors: Timms Mark , Steel Rohan 
Published: December 2021

AbstractThe proteotypic human EPO peptides YLLEAK (T4), SLTTLLR (T11), TITADTFR (T14), and VYSNFLR (T17) are often used to confirm the presence of recombinant human EPO (rhEPO) in equine samples. Each of these peptides contains one or more isomeric leucine or isoleucine amino acids, raising the possibility that a simple leucine/isoleucine substitution could lead to a false identification when compared with a rhEPO reference standard. To examine this possibility variants of these four peptides were analysed by liquid chromatography–tandem mass spectrometry (LC‐MS/MS). These studies indicate that confirmation of rhEPO in equine samples by immuno‐affinity capture and LC‐MS/MS analysis is true and accurate. It was also found that chromatography played a greater role in determining LC‐MS/MS specificity than tandem mass spectrometry and that, in the case of more hydrophilic peptides, the accuracy of peptide identification could be enhanced by the inclusion of 13C and 15N labelled peptide internal standards.
Asynchronous flowering patterns in saguaro cacti (Carnegiea gigantea)
Authors: Foley Theresa , Swann Don E. , Sotelo Guadalupe , Perkins Nicholas , Winkler Daniel E. 
Published: December 2021

AbstractThe saguaro cactus (Carnegiea gigantea [Engelm.] Britton & Rose) is a keystone species endemic to the Sonoran Desert of northern Mexico and the southwestern United States. The saguaro produces large white flowers near its stem apex (crown) during April–June, which bloom at night and close the following day. In 1924, Duncan Johnson reported that saguaro floral buds are likely to have an asymmetrical distribution in which buds occur in higher densities on the eastern half of a plant's crown. Using technology not available to Johnson, we tested his observations to determine whether flowers are asymmetrically distributed using repeat photography. We also tested whether there is a seasonal pattern of flowering that may explain Johnson’s observations. We tracked intra‐individual flowering phenology of 20 saguaros and measured 2372 flowers across two reproductive seasons in Saguaro National Park, Tucson, Arizona. Flowers first appeared on the east side of all saguaro crowns at the start of the reproductive season, and then spread radially in a counterclockwise direction as the season progressed. In contrast to previous reports, saguaro flowers were consistently more abundant on the northern part of the crown than in the eastern part. To our knowledge, this study is the first to document a seasonal, counterclockwise pattern of asynchronous flowering in saguaro or any angiosperm. We discuss potential drivers of this phenomenon as well as implications for saguaros responding to climate change.
Introduced mangroves escape damage from marine and terrestrial enemies
Authors: Davidson Timothy M. , Smith Celia M. , Torchin Mark E. 
Published: December 2021

AbstractThe enemy release hypothesis (ERH) posits that introduced species often leave their enemies behind when introduced to a new range. This release from enemies may allow introduced species to achieve higher growth and reproduction and may explain why some invaders flourish in new locations. Red mangroves (Rhizophora mangle) were introduced to Hawaiʻi from Florida over a century ago. Because Hawaiʻi has no native mangroves, the arrival of R. mangle fundamentally changed the structure and function of estuarine shorelines. While numerous enemies affect red mangroves in their native range (tropical America), in Hawaiʻi, mangroves apparently experience little herbivory, which may explain why introduced mangroves are so productive, fecund, and continue to spread. In this study, we compared the effects of enemies in native and introduced populations of brackish red mangroves (R. mangle) in 8–10 sites in the native range (Florida, Belize, and Panama) and introduced range of mangroves (Hawaiʻi). At each site, we measured the (1) occurrence of enemies using timed visual surveys, (2) occurrence of damage to different mangrove structures (leaves, apical buds, dead twigs, roots, propagules, and seedlings), and (3) rate of propagule herbivory using tethering experiments. Consistent with the ERH, we found an order of magnitude less damage and fewer enemies in introduced than native mangrove sites. While introduced mangroves harbored few enemies and minimal damage, native mangroves were affected by numerous enemies, including leaf‐eating crabs, specialist bud moths, wood‐boring insects and isopods, and propagule predators. These patterns were consistent across all plant structures (roots to leaves), among marine and terrestrial enemies, and across functional groups (browsers, borers, pathogens, etc.), which demonstrates enemy escape occurs consistently among different functional groups and via trophic (e.g., herbivores) and non‐trophic (e.g., root borers) interactions. Our study is among the first biogeographical enemy release studies to take a comprehensive approach to quantifying the occurrence of damage from a broad suite of marine and terrestrial taxa across an array of wetland plant structures. Understanding how natural enemies alter this key foundation species will become increasingly relevant globally as mangroves continue to invade new regions through intentional plantings or range expansion driven by climate change.
A review on tactile IoT: Architecture, requirements, prospects, and future directions
Authors: Ray Partha Pratim 
Published: December 2021

AbstractTactile internet (TI) has emerged as a new possibility into revolutionizing whole society by involving human beings, communication aspects, and industrial operation. Main purpose of TI is to disseminate perceptual, that is, haptic information to remote industry machines for pouring skills and expertise as if it were actually accomplished by a person in reality. Internet of things is an established tool to serve various smart application development that mainly depends on sensors, actuators, communication technology, and cloud‐based services. Existing studies do not clearly mention the key requirements, architectural standardization and TI enabled functions to transfer haptic information via a suitable communication media. Although 5G has been considered as a valuable core of TI infrastructure, lack of actual implementation and related evidence has raised a dilemma about its effectiveness for industry applications leaving with no direction. In this article, we present architectural and system model‐wise development of tactile internet of things for possible industry application realization. We also present key requirements, functional and optimal aspects of tactile internet of things. Study of potential communication technologies and state‐of‐the‐art study on recent works on TI‐based approaches are paved. Lastly, we present key open challenges and future direction to augment this problem.
Modelling spatio‐temporal soil moisture dynamics in mountain tundra
Authors: Tyystjärvi Vilna , Kemppinen Julia , Luoto Miska , Aalto Tuula , Markkanen Tiina , Launiainen Samuli , Kieloaho Antti‐Jussi , Aalto Juha 
Published: December 2021

AbstractSoil moisture has a fundamental influence on the processes and functions of tundra ecosystems. Yet, the local dynamics of soil moisture are often ignored, due to the lack of fine resolution, spatially extensive data. In this study, we modelled soil moisture with two mechanistic models, SpaFHy (a catchment‐scale hydrological model) and JSBACH (a global land surface model), and examined the results in comparison with extensive growing‐season field measurements over a mountain tundra area in northwestern Finland. Our results show that soil moisture varies considerably in the study area and this variation creates a mosaic of moisture conditions, ranging from dry ridges (growing season average 12 VWC%, Volumetric Water Content) to water‐logged mires (65 VWC%). The models, particularly SpaFHy, simulated temporal soil moisture dynamics reasonably well in parts of the landscape, but both underestimated the range of variation spatially and temporally. Soil properties and topography were important drivers of spatial variation in soil moisture dynamics. By testing the applicability of two mechanistic models to predict fine‐scale spatial and temporal variability in soil moisture, this study paves the way towards understanding the functioning of tundra ecosystems under climate change.
Supramolecular‐mediated ball‐in‐ball porous carbon nanospheres for ultrafast energy storage
Authors: Yao Lei , Lin Junsheng , Chen Yuanyuan , Li Xiujuan , Wang Dongrui , Yang Haitao , Deng Libo , Zheng Zijian 
Published: December 2021

AbstractHierarchical porous carbons are the most viable electrode material for supercapacitors because of their balanced capacitive performance and chemical stability. Their pore connectivity plays a pivotal role in electrolyte transport, which is quantified by a new parameter, defined in this work as the longest possible pore separation (LPPS). Herein, we report hierarchical porous carbon nanospheres (HPC‐NS) with a unique ball‐in‐ball structure, which is achieved by the pyrolysis of a supramolecular complex of γ‐cyclodextrin (γ‐CD)/PEO‐PPO‐PEO (F127). This approach differs from the conventional soft‐templating method in that, apart from the assembly of the monomicelles that leads to the host nanospheres (approximately 300 nm), the γ‐CD‐containing monomicelles themselves are converted to small porous carbon nanospheres (<10 nm), which results in an ultralow LPPS of 10 nm, representing the best‐known pore connectivity of the HPC family. The HPC‐NS delivers a high specific capacitance (405 F g−1 at 1 A g−1 and 71% capacitance retention at 200 A g−1), wide voltage window (up to 1.6 V), and simultaneously high energy and power densities (24.3 Wh kg−1 at a power density of 151 W kg−1 and 9 Wh kg−1 at 105 W kg−1) in aqueous electrolytes. This new strategy boosts the development of porous carbon electrodes for aqueous supercapacitors with simultaneously high power and energy densities.
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