bluuebunny/crossref_metadata_2025_split huggingface dataset:
ТРАНСФОРМАЦІЙНІ ПРОЦЕСИ У СВІТІ ТА ЇХ ВПЛИВ НА ФОРМУВАННЯ НОВОГО СВІТОВОГО ПОРЯДКУ
Authors: Sulima Yevhen 
Published: September 2021

У статті розглядаються питання розподілу світу між розвиненими державами: чому виникає потреба розмежування країн за певною ознакою, яким чином проводиться розподіл, які структурні елементи приймають участь та що відбувається із геополітичною ситуацією внаслідок поділу сфер впливу. Автор наголошує на довготривалості, послідовності та невідворотності цих процесів. Наукова новизна статті полягає в тому, що автор не тільки використовує філософію для побудови логічної моделі світового порядку, але і вдається до використання історичного, економічного та політичного підходів для різнобічного аналізу цього питання та позбавлення суб'єктивізму при його оцінці. В дослідженні розглядаються поняття біполярності, однополярності та багатополярності - їх значення, суть, практичні приклади з історії людства. Автор проводить онтологічний аналіз світового порядку, як важливої складової людського буття. Основна увага приділяється наддержавам: США та СРСР. Автор з'ясовує, які чинники призвели до гегемонії цих країн, та які виклики це створює для сьогодення. Важлива увага приділяється розпаду Радянського союзу, як природнього завершення циклу панування наддержави та падіння біполярної картини світу. В результаті зароджується новий світовий порядок із багатьма державами та міжнародними угрупуваннями на чолі, що свідчить про перехід до багатополюсного поділу світу за сферами впливу. Автор досліджує трансформаційні процеси, які відбулися внаслідок цього переходу, описує основних лідерів та претендентів на місце нового гегемона. Головним фаворитом є Китай - автор ретельно досліджує міжнародну діяльність, соціально-економічні показники, політику та власні думки Піднебесної стосовно позиції наддержави. Тим не менш, у статті виділяється ціла група чинників наддержавності, яким об'єктивно не відповідають ні Китай, ні основні конкуренти, ЄС та Росія. Аналізуються основні моменти, які гальмують вищезгадані країни та не дозволяють їм посісти місце нового світового гегемона.
Pengaruh Rasio Keuangan Terhadap Pertumbuhan Laba Pada Perusahaan Sub Sektor Otomotif Dan Komponen Yang Terdaftar Di Bursa Efek Indonesia Periode 2014 – 2018
Authors: Mardiana Mardiana , Verahastuti Camelia , Nur Rosita 
Published: September 2021

This study aims to determine and analyze the effect of Current Ratio (CR), Total Asset Turnover (TATO), and Return On Asset (ROA) on profit growth in automotive sub-sector companies and components listed on the Indonesia Stock Exchange for the period 2014-2018. used in this study is secondary data sourced from annual performance summary data of listed companies, obtained from thewebsite official www.idx.co.id.. The results of the study partially show that thevariable Current Ratio (CR)has a negative and insignificant effect on profit growth;variable Total Asset Turnover (TATO)has a negative and insignificant effect on profit growth; while the variable Return on Assets (ROA) has a significant positive effect on profit growth. Simultaneously, it shows that the variables Current Ratio (CR), Total Asset Turnover (TATO), and Return On Asset (ROA) have a significant effect on profit growth.
Tipificaciones y nuevos sinónimos en Sapindaceae relacionadas a la Flora de Argentina
Authors: Ferrucci María Silvia 
Published: September 2021

Introducción y objetivos: Sapindaceae está representada en Argentina por 15 géneros nativos con 45 especies en total. En el contexto del tratamiento taxonómico de esta familia para el proyecto Flora Argentina, se identifican numerosos nombres que precisan ser tipificados para estabilizar su nomenclatura, así como la aclaración de material tipo clásico y la propuesta de nuevos sinónimos. Todos estos nombres pertenecen a los géneros Allophylus, Athyana, Cardiospermum, Cupania, Diatenopteryx, Diplokeleba, Dodonaea, Guindilia, Paullinia, Serjania y Thinouia.
M&M: El tratamiento nomenclatural se basa en el análisis de los protólogos, más el estudio de material tipo ya sea físico o a través de imágenes en línea. La lectotipificación se realiza de acuerdo a las indicaciones del Código Internacional de Nomenclatura para Algas, Hongos y Plantas.
Resultados y conclusiones: Se designan lectotipos para 39 taxones de Sapindaceae relacionados a la Flora de Argentina. Se aportan aclaraciones sobre los holotipos de tres especies. Se proponen dos nuevos sinónimos.
Clinical Exercise Considerations for Opioid Addiction Recovery
Authors: Torres Emma , Hillman Angela R. 
Published: September 2021

ABSTRACT
According to the American Psychiatric Association, in 2018, approximately 2 million Americans were suffering from a substance abuse disorder, defined as substance abuse and dependence (1), related to opioids that were prescribed for pain management (2), while worldwide, it is estimated this approaches 16 million (3). Consequently, exercise clinicians will be increasingly exposed to individuals who have been affected by opioids and should therefore know how these drugs affect physiological functioning and how exercise can play a role in opioid addiction recovery. This review article is intended to provide some of this information.
Prevalence of underlying malignancies in complex cysts of the breast
Authors: Gerets J.C.W.L. , Kool M. , Simons P.C.G. , Aarts F. , Vogelaar F.J. 
Published: September 2021

INTRODUCTION: The management of complex cysts of the breast is an ongoing topic of discussion. The aim of this study was to determine the prevalence of underlying malignancy in radiologically diagnosed complex cysts, and to assess whether watchful waiting could be the preferred method to safely manage complex cysts of the breast. SUBJECTS AND METHODS: A single-center retrospective study was performed between May 2003 and November 2019 in the VieCuri Medical Centre. Women with a radiologically diagnosed complex cyst of the breast were included. Prevalence of underlying malignancy was calculated, as were absolute risk reduction and number needed to treat in order to diagnose malignancy. In addition, patient characteristics were compared to determine characteristics associated with malignancy. RESULTS: Of 78 radiologically diagnosed complex cysts of the breast, five (6,4%) were found to be malignant. The number needed to treat was calculated at 12,8 (absolute riks reduction 0,078). Age (P = 0,003) was associated with malignancy. CONCLUSION: Complex cysts of the breast could be managed more conservatively. Patient characteristics can be used to assess the eligibility for radiological follow-up. This, in turn, would lead to a lower NNT and possibly a decrease in disease burden and healthcare costs.
Методологічні підходи до визначення необхідності врахування різних технологічних умов експлуатації елементів енергоблоків АЕС під час оцінки їх сейсмостійкості відповідно до нормативних вимог
Authors: Shugaylo O-r , Ryzhov D. , Zhabin O. , Danylchuk I. , Trusov I. , Posokh V. , Kurov V. 
Published: September 2021

Нормативні вимоги до оцінки сейсмостійкості елементів енергоблоків атомних електростанцій передбачають необхідність врахування різних технологічних умов експлуатації в сполученні із сейсмічними впливами. Раніше вже були проаналізовані переваги та недоліки запропонованого експлуатуючою організацією узагальненого алгоритму дій щодо визначення необхідності (або її відсутності) врахування різних сполучень експлуатаційних та сейсмічних навантажень. Встановлено, що вказаний аспект потребує ґрунтовного дослідження для тепломеханічного обладнання, сейсмостійкість якого підтверджена методом GIP-ВВЕР, зокрема: вплив несейсмічних навантажень у разі порушення нормальної експлуатації та проєктної аварії на існуючі результати оцінки сейсмостійкості тепломеханічного обладнання методом GIP-ВВЕР. До того, не вирішеним залишилось також питання коректного визначення технологічних параметрів, які відповідають порушенню нормальної експлуатації та проєктній аварії, для систем та елементів енергоблоків атомних електростанцій, для яких в технологічному регламенті безпечної експлуатації енергоблока не встановлені умови та межі безпечної експлуатації.
У статті містяться методологічні підходи до вирішення вказаних проблемних питань.
Стаття входить до циклу публікацій в журналі «Ядерна та радіаційна безпека», присвячених розгляду нормативних вимог до сполучень експлуатаційних та сейсмічних навантажень під час оцінки сейсмостійкості різноманітних елементів атомних електростанцій.
Evaluating the Accuracy of an Equivalent Linear Model in Predicting Peak Displacement of Seismic Isolation Systems using Single Friction Pendulum Bearings
Authors: Nguyen Thanh-Truc , Dao Nhan Dinh 
Published: September 2021

This study evaluates the accuracy of an equivalent linear model in predicting peak nonlinear time-history displacement of seismic isolation systems with single friction pendulum bearings. To perform this evaluation, dynamic response of numerical models of 120 isolation systems subjected to 390 strong earthquake ground motions, including motions with pulse and motions without pulse, was analyzed and statistically processed. The results show that the equivalent linear model can partly predict the peak displacement of its counterpart nonlinear model. However, the equivalent model can also underestimate or overestimate the peak displacement. On average sense, the equivalent linear model underestimates small peak displacement and overestimates large peak displacement. It is also observed that the relationship between linear and nonlinear peak displacements depends on ground motion types. Based on the analysis data, equations representing relationship between linear and nonlinear peak displacements at different reliable levels for different ground motion types were proposed. These equations can be used in practice.
Fuzzy-multi-mode Resource-constrained Discrete Time-cost-resource Optimization in Project Scheduling Using ENSCBO
Authors: Kaveh Ali , Rajabi Farivar 
Published: September 2021

Construction companies are required to employ effective methods of project planning and scheduling in today's competitive environment. Time and cost are critical factors in project success, and they can vary based on the type and amount of resources used for activities, such as labor, tools, and materials. In addition, resource leveling strategies that are used to limit fluctuations in a project's resource consumption also affect project time and cost. The multi-mode resource-constrained discrete-time–cost-resource optimization (MRC-DTCRO) is an optimization tool that is developed for scheduling of a set of activities involving multiple execution modes with the aim of minimizing time, cost, and resource moment. Moreover, uncertainty in cost should be accounted for in project planning because activities are exposed to risks that can cause delays and budget overruns. This paper presents a fuzzy-multi-mode resource-constrained discrete-time–cost-resource optimization (F-MRC-DTCRO) model for the time-cost-resource moment tradeoff in a fuzzy environment while satisfying all the project constraints. In the proposed model, fuzzy numbers are used to characterize the uncertainty of direct cost of activities. Using this model, different risk acceptance levels of the decision maker can be addressed in the optimization process. A newly developed multi-objective optimization algorithm called ENSCBO is used to search non-dominated solutions to the fuzzy multi-objective model. Finally, the developed model is applied to solve a benchmark test problem. The results indicate that incorporating the fuzzy structure of uncertainty in costs to previously developed MRC-DTCRO models facilitates the decision-making process and provides more realistic solutions.
REFLEKSI SOSIOPSIKOLOGIS MASYARAKAT MELALUI KARAKTER TOKOH CUPAK GURANTANG DI DESA TEKO KECAMATAN PRINGGABAYA
Authors: Huda Khairul 
Published: September 2021

Penelitian yang digunakan oleh peneliti adalah deskriptif kualitatif, bertujuan untuk mendeskripsikan informasi tentang kehidupan sosiopsikologis masyarakakat yang sekarang terjadi melalui karakter tokoh Cupak Gurantang. Metode pengumpulan data yang digunakan peneliti adalah metode telaah, tekhnik sadap dan wawancara. Sedangkan tekhnik analisis data dapat menggunakan tiga langkah: data redction(reduksi daTa), display data (penyajian data) dan verification/conclusion drawing (kesimpulan). Berdasarkan hasil penelitian ini, disimpulkan bahwa refleksi sosiopsikologis perilaku masyarakat terpuji dan tidak terpuji pada masyarakat sekarang masih ada. Perilaku masyarakat sekarang tidak terlepas dari berbagai konflik yang ada disekitarnya. Demi sebuah kepentingan, seseorang melakukan segala upaya untuk memenuhi apa yang diinginkannya, dan sekaligus sebagai pemicu timbulnya berbagai perilaku, baik perilaku terpuji maupun perilaku tidak terpuji. Seperti penggambaran tokoh Cupak yang memiliki sifat tidak terpuji: serakah, dusta, tidak adil, malas, curang, tidak amanah dan sebagainya. Begitu juga sebaliknya penggambaran tokoh Gurantang yang memiliki sifat terpuji: adil, rajin, kreatif, kerja keras, sopan santun, jujur dan sebagainya.Kata kunci: : Refleksi Sosiopsikologis, Masyarakat dan Karakter Tokoh Cupak Gurantang.
Association of Derived Neutrophil-To-Lymphocyte Ratio With Prognosis of Coronary Heart Disease After PCI
Authors: Liu Gang-Qiong , Zhang Wen-Jing , Shangguan Jia-Hong , Zhu Xiao-Dan , Wang Wei , Guo Qian-Qian , Zhang Jian-Chao , Wang Kai , Liu Zhi-Yu , Song Feng-Hua , Fan Lei , Zheng Ying-Ying , Zhang Jin-Ying 
Published: September 2021

Aims: The present study aimed to investigate the prognostic role of derived neutrophil-to-lymphocyte ratio (dNLR) in patients with coronary heart disease (CHD) after PCI.Methods: A total of 3,561 post-PCI patients with CHD were retrospectively enrolled in the CORFCHD-ZZ study from January 2013 to December 2017. The patients (3,462) were divided into three groups according to dNLR tertiles: the first tertile (dNLR &lt; 1.36; n = 1,139), second tertile (1.36 ≥ dNLR &lt; 1.96; n = 1,166), and third tertile(dNLR ≥ 1.96; n = 1,157). The mean follow-up time was 37.59 ± 22.24 months. The primary endpoint was defined as mortality (including all-cause death and cardiac death), and the secondary endpoint was major adverse cardiovascular events (MACEs) and major adverse cardiovascular and cerebrovascular events (MACCEs).Results: There were 2,644 patients with acute coronary syndrome (ACS) and 838 patients with chronic coronary syndrome (CCS) in the present study. In the total population, the all-cause mortality (ACM) and cardiac mortality (CM) incidence was significantly higher in the third tertile than in the first tertile [hazard risk (HR) = 1.8 (95% CI: 1.2–2.8), p = 0.006 and HR = 2.1 (95% CI: 1.23–3.8), p = 0.009, respectively]. Multivariate Cox regression analyses suggested that compared with the patients in the first tertile than those in the third tertile, the risk of ACM was increased 1.763 times (HR = 1.763, 95% CI: 1.133–2.743, p = 0.012), and the risk of CM was increased 1.763 times (HR = 1.961, 95% CI: 1.083–3.550, p = 0.026) in the higher dNLR group during the long-term follow-up. In both ACS patients and CCS patients, there were significant differences among the three groups in the incidence of ACM in univariate analysis. We also found that the incidence of CM was significantly different among the three groups in CCS patients in both univariate analysis (HR = 3.541, 95% CI: 1.154–10.863, p = 0.027) and multivariate analysis (HR = 3.136, 95% CI: 1.015–9.690, p = 0.047).Conclusion: The present study suggested that dNLR is an independent and novel predictor of mortality in CHD patients who underwent PCI.
Activity Tracking Using Ear-Level Accelerometers
Authors: Skoglund Martin A. , Balzi Giovanni , Jensen Emil Lindegaard , Bhuiyan Tanveer A. , Rotger-Griful Sergi 
Published: September 2021

Introduction: By means of adding more sensor technology, modern hearing aids (HAs) strive to become better, more personalized, and self-adaptive devices that can handle environmental changes and cope with the day-to-day fitness of the users. The latest HA technology available in the market already combines sound analysis with motion activity classification based on accelerometers to adjust settings. While there is a lot of research in activity tracking using accelerometers in sports applications and consumer electronics, there is not yet much in hearing research.Objective: This study investigates the feasibility of activity tracking with ear-level accelerometers and how it compares to waist-mounted accelerometers, which is a more common measurement location.Method: The activity classification methods in this study are based on supervised learning. The experimental set up consisted of 21 subjects, equipped with two XSens MTw Awinda at ear-level and one at waist-level, performing nine different activities.Results: The highest accuracy on our experimental data as obtained with the combination of Bagging and Classification tree techniques. The total accuracy over all activities and users was 84% (ear-level), 90% (waist-level), and 91% (ear-level + waist-level). Most prominently, the classes, namely, standing, jogging, laying (on one side), laying (face-down), and walking all have an accuracy of above 90%. Furthermore, estimated ear-level step-detection accuracy was 95% in walking and 90% in jogging.Conclusion: It is demonstrated that several activities can be classified, using ear-level accelerometers, with an accuracy that is on par with waist-level. It is indicated that step-detection accuracy is comparable to a high-performance wrist device. These findings are encouraging for the development of activity applications in hearing healthcare.
Soluble Klotho Is Decreased in Children With Type 1 Diabetes and Correlated With Metabolic Control
Authors: Zubkiewicz-Kucharska Agnieszka , Wikiera Beata , Noczyńska Anna 
Published: September 2021

Klotho concentration may be considered as a prognostic factor in the development of chronic complications of diabetes. Moreover, decrease in sKlotho concentration may contribute to beta cell apoptosis and type 1 diabetes development. The aim of this study was to evaluate if sKlotho protein concentration in children with type 1 diabetes (T1D) and its correlation with classical risk factors of chronic complications of diabetes: dysglycemia and endothelial dysfunction.Material and methodsIn a cross-section single center study the levels of soluble Klotho protein in 80 T1D (37 boys) and 34 healthy children (controls, 15 boys). Micro- and macroangiopathy were excluded and renal function was normal in all participants. Serum sKlotho, sICAM-1, sVCAM-1 and E-selectin levels were measured.ResultsThe concentration of sKlotho was lower in T1D than in the controls (2041.9 ± 1017.6 pg/mL vs. 2790.3 ± 1423.9 pg/mL, p=0.0113). sICAM-1, sVCAM-1 and E-selectin concentrations were comparable in patients and controls. In T1D, sKlotho was not correlated with the duration of diabetes. Klotho and E-selectin were correlated with HbA1c (r=-0.31, P=0.0066 and r=0.25, P=0.0351, respectively), but not with AVBG and blood glucose SD. Correlations of sKlotho with total cholesterol (r=0.31, P=0.0129), HDL-cholesterol (r=0.43, P=0.0011) and LDL-cholesterol (r=0.28, P=0.0412), but not with triglycerides, were found. Likewise, Klotho was not correlated with sICAM-1, sVCAM-1, and E-selectin concentrations.ConclusionsThis study reports the significantly lower level of s-Klotho in children with type 1 diabetes, correlated with HbA1c and HDL cholesterol, but not with the adhesion molecules concentrations nor the duration of the disease. Negative correlation between the levels of HbA1c and soluble Klotho may suggest its possible involvement in the development of chronic diabetes complications.
Characterization of Modification Patterns, Biological Function, Clinical Implication, and Immune Microenvironment Association of m6A Regulators in Pancreatic Cancer
Authors: Fang Kun , Qu Hairong , Wang Jiapei , Tang Desheng , Yan Changsheng , Ma Jiamin , Gao Lei 
Published: September 2021

Objective: N6-methyladenosine (m6A) modification may modulate various biological processes. Nonetheless, clinical implications of m6A modification in pancreatic cancer are undefined. Herein, this study comprehensively characterized the m6A modification patterns in pancreatic cancer based on m6A regulators.Methods: Genetic mutation and expression pattern of 21 m6A regulators and their correlations were assessed in pancreatic cancer from TCGA dataset. m6A modification patterns were clustered using unsupervised clustering analysis in TCGA and ICGC datasets. Differences in survival, biological functions and immune cell infiltrations were assessed between modification patterns. A m6A scoring system was developed by principal component analysis. Genetic mutations and TIDE scores were compared between high and low m6A score groups.Results: ZC3H13 (11%), RBM15B (9%), YTHDF1 (8%), and YTHDC1 (6%) frequently occurred mutations among m6A regulators. Also, most of regulators were distinctly dysregulated in pancreatic cancer. There were tight crosslinks between regulators. Two m6A modification patterns were constructed, with distinct prognoses, immune cell infiltration and biological functions. Furthermore, we quantified m6A score in each sample. High m6A scores indicated undesirable clinical outcomes. There were more frequent mutations in high m6A score samples. Lower TIDE score was found in high m6A score group, with AUC = 0.61, indicating that m6A scores might be used for predicting the response to immunotherapy.Conclusion: Collectively, these data demonstrated that m6A modification participates pancreatic cancer progress and ornaments immune microenvironment, providing an insight into pancreatic cancer pathogenesis and facilitating precision medicine development.
Barrett’s Epithelium to Esophageal Adenocarcinoma: Is There a “Point of No Return”?
Authors: Panda Anshuman , Shin Mi ryung , Cheng Christina , Bajpai Manisha 
Published: September 2021

Background: Esophageal adenocarcinoma (EA) arises from Barrett’s epithelium (BE), and chronic gastroesophageal reflux disease is considered the strongest risk factor for disease progression. All BE patients undergo acid suppressive therapy, surveillance, and BE removal by surgery or endoscopic ablation, yet the incidence of EAC continues to increase. Despite the known side effects and mortality, the one-size-fits-all approach is the standard clinical management as there are no reliable methods for risk stratification.Methods: Paired-end Illumina NextSeq500 RNA sequencing was performed on total RNA extracted from 20-week intervals (0, 20, 40, and 60 W) of an in vitro BE carcinogenesis (BEC) model to construct time series global gene expression patterns (GEPs). The cells from two strategic time points (20 and 40 W) based on the GEPs were grown for another 20 weeks, with and without further acid and bile salt (ABS) stimulation, and the recurrent neoplastic cell phenotypes were evaluated.Results: Hierarchical clustering of 866 genes with ≥ twofold change in transcript levels across the four time points revealed maximum variation between the BEC20W and BEC40W cells. Enrichment analysis confirmed that the genes altered ≥ twofold during this window period associated with carcinogenesis and malignancy. Intriguingly, the BEC20W cells required further ABS exposure to gain neoplastic changes, but the BEC40W cells progressed to malignant transformation after 20 weeks even in the absence of additional ABS.Discussion: The transcriptomic gene expression patterns in the BEC model demonstrate evidence of a clear threshold in the progression of BE to malignancy. Catastrophic transcriptomic changes during a window period culminate in the commitment of the BE cells to a “point of no return,” and removal of ABS is not effective in preventing their malignant transformation. Discerning this “point of no return” during BE surveillance by tracking the GEPs has the potential to evaluate risk of BE progression and enable personalized clinical management.