bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain tumor detection and classification using machine learning: a comprehensive survey
Authors: Amin Javaria , Sharif Muhammad , Haldorai Anandakumar , Yasmin Mussarat , Nayak Ramesh Sundar 
Published: November 2021

AbstractBrain tumor occurs owing to uncontrolled and rapid growth of cells. If not treated at an initial phase, it may lead to death. Despite many significant efforts and promising outcomes in this domain, accurate segmentation and classification remain a challenging task. A major challenge for brain tumor detection arises from the variations in tumor location, shape, and size. The objective of this survey is to deliver a comprehensive literature on brain tumor detection through magnetic resonance imaging to help the researchers. This survey covered the anatomy of brain tumors, publicly available datasets, enhancement techniques, segmentation, feature extraction, classification, and deep learning, transfer learning and quantum machine learning for brain tumors analysis. Finally, this survey provides all important literature for the detection of brain tumors with their advantages, limitations, developments, and future trends.
An electromagnetic arrayed pump to create arbitrary velocity profiles in fluid
Authors: Hashemi Seyed Peyman , Karafi Mohammad Reza , Sadeghi Mohammad Hossein , Esfedan Vahid Rezaei 
Published: November 2021

AbstractThe present paper is conducted to develop a new structure of an electromagnetic pump capable of controlling the magnetic field in a rectangular channel. Common electromagnetic pumps do not create uniform velocity profiles in the cross-section of the channel. In these pumps, an M-shape profile is created since the fluid velocity in the vicinity of the walls is higher than that in its center. Herein, the arbitrary velocity profiles in the electromagnetic pump are generated by introducing an arrayed structure of the coils in the electromagnetic pump and implementing 3D numerical simulation in the finite element software COMSOL. The dimensions of the rectangular channel are 5.5 × 150 mm2. Moreover, the magnetic field is provided using a core with an arrayed structure made of low-carbon iron, as well as five couples of coils. 20% NaoH solution is utilized as the fluid (conductivity: 40 S/m). The arrayed pump is fabricated and experimentally created an arbitrary velocity profile. The pressure of the pump in every single array is 12 Pa and the flow rate is equal to 3375 mm3/s. According to the results, there is a good agreement between the experimental test carried out herein and the simulated models.Article highlights

This is the first time that the idea of arrayed electromagnetic pump is presented. This pump uses a special arrayed core with coils; by controlling the current of each coil and the direction of the currents, the magnetic field under the core could be adjusted. By changing the magnetic field at any position in the width of the channel, the Lorentz force alters, which leads to different velocity and pressure profiles.

Using COMSOL multiphysics software, the electromagnetic pump was simulated in real size compared to the experimental model. Subsequently, the simulation model was verified and different velocity profiles were generated by activation and deactivation of different coils. The pressure and velocity curves and contours were extracted.

The experimental setup was manufactured and assembled. NaOH solution was utilized as the fluid. Afterwards, different modes of coil activations were investigated and the pressure and velocity profiles of the pump were calculated.
A Risk Model for Predicting Fetuses with Trisomy 21 Using Alpha-Fetoprotein Variants L2 Combined with Maternal Serum Biomarkers in Early Pregnancy
Authors: Chen Yiming , Wu Bin , Chen Yijie , Ning Wenwen , Zhang Huimin 
Published: November 2021

AbstractTo establish a risk prediction model and the clinical value of trisomy 21 using alpha-fetoprotein variants L2 (AFP-L2) combined with maternal serum biomarkers and nuchal translucency (NT) thickness in early pregnancy. A retrospective case–control study was conducted. The subjects were divided into the case group (n = 40) or the control group (n = 40). An enzyme-linked immunosorbent assay was used to measure the maternal serum AFP-L2 level in both groups. The AFP-L2 single-index or multi-index combined risk model was used to predict the efficiency of trisomy 21. The best cut-off value and area under the curve (AUC) were determined to evaluate the predictive efficacy of different risk models constructed by AFP-L2. The maternal serum AFP-L2 level in the case group was 1.59 (0.61–3.61) Multiple of medium (MoM), which was higher than 1.00 (0.39–2.12) MoM in the control group (P < 0.001). The free beta-human chorionic gonadotropin (free β-hCG) level and NT in the case group were significantly higher than those in the control group (P < 0.001). The pregnancy-associated plasma protein A (PAPP-A) level in the case group was lower than that in the control group (P < 0.001). The AUC of AFP-L2 in predicting trisomy 21 was 0.797. After considering the maternal serum AFP-L2 level, the AUC, detection rate (DR), positive predictive value (PPV), negative predictive value (NPV), falsepositive rate (FPR), false negative rate (FNR), positive likelihood ratio (+LR), and negative likelihood ratio (-LR) were significantly improved. In this study, PAPP-A + free β-hCG + NT + AFP-L2 and PAPP-A + free β-hCG + AFP-L2 increased the integrated discrimination improvement (IDI) and net classification improvement (NRI) of predicting fetuses with trisomy 21 (1.10% and 5.27%; 11.07% and 2.78%) (1.10% and 5.27%; 11.07% and 2.78%), respectively, after considering the maternal serum AFP-L2 level. The maternal serum AFP-L2 level in early pregnancy had high sensitivity and specificity, and it was a good biomarker to predict fetuses with trisomy 21.
Real World Evidence in Medical Cannabis Research
Authors: Banerjee Rishi , Erridge Simon , Salazar Oliver , Mangal Nagina , Couch Daniel , Pacchetti Barbara , Sodergren Mikael Hans 
Published: November 2021

Abstract
Background
Whilst access to cannabis-based medicinal products (CBMPs) has increased globally subject to relaxation of scheduling laws globally, one of the main barriers to appropriate patient access remains a paucity of high-quality evidence surrounding their clinical effects.

Discussion
Whilst randomised controlled trials (RCTs) remain the gold-standard for clinical evaluation, there are notable barriers to their implementation. Development of CBMPs requires novel approaches of evidence collection to address these challenges. Real world evidence (RWE) presents a solution to not only both provide immediate impact on clinical care, but also inform well-conducted RCTs. RWE is defined as evidence derived from health data sourced from non-interventional studies, registries, electronic health records and insurance data. Currently it is used mostly to monitor post-approval safety requirements allowing for long-term pharmacovigilance. However, RWE has the potential to be used in conjunction or as an extension to RCTs to both broaden and streamline the process of evidence generation.

Conclusion
Novel approaches of data collection and analysis will be integral to improving clinical evidence on CBMPs. RWE can be used in conjunction or as an extension to RCTs to increase the speed of evidence generation, as well as reduce costs. Currently, there is an abundance of potential data however, whilst a number of platforms now exist to capture real world data it is important the right tools and analysis are utilised to unlock potential insights from these.
Foregrounding Daily Data Collection on Archaeological Fieldwork
Authors: Petrosyan Artur , Azizbekyan Hayk , Gasparyan Boris , Dan Roberto , Bobokhyan Arsen , Amiryan Mariam 
Published: November 2021

OverviewDaily data collection during archaeological fieldwork forms the basis for later interpretation and analysis. Across the world, we observe a wide variety of digital data collection methods and tools employed during fieldwork. Here, we detail the daily practices at four recent survey and excavation projects in the South Caucasian country of Armenia. As archaeology continues to become ever more digital, it is useful to consider these day-to-day recording processes at a typical field project. We provide details on both the types of data collected and the ways they are collected so as to foreground these topics. Finally, we reflect on how our work is currently impacted by digital changes and how it may continue to change in the future.
Multiple System Atrophy Caregivers’ Experience: A Mixed Methods Study
Authors: Langford Beth , Zhou Yiling , Miyasaki Janis M. 
Published: November 2021

Abstract:Background:Multiple system atrophy (MSA) is a rare Parkinson-plus syndrome with rapid progression and a high symptom burden. The experience of caregivers of people with MSA has not been closely examined. We therefore sought to document the impact of MSA on caregivers using a mixed methods approach.Methods:Patients and caregivers were recruited from a movement disorders program in Edmonton, Canada. Participants completed the following survey instruments based on their own or their loved one’s symptoms: 36-Item Short-Form Health Survey (SF-36), Multiple System Atrophy health-related Quality of Life scale (MSA-QoL), and Hospital Anxiety and Depression Scale (HADS). Caregivers also completed the Zarit Burden Interview and HADS based on their own experience. Qualitative data were obtained through semi-structured interviews.Results:Nine people with MSA (PwMSA) (age range: 48–78 years) and 11 caregivers (49–76 years) participated. All completed surveys; 7 PwMSA and 10 caregivers were interviewed. Eight PwMSA had the parkinsonian type of MSA (MSA-P) and one a mixed type. Caregivers had on average mild-moderate caregiver burden and mild anxiety. Caregiver burden and anxiety were correlated. Qualitative subthemes under the caregiving theme included keeping the patient safe, caregivers’ own health, and communication symptoms cause frustration. The rapid progression of illness was bewildering to caregivers and increased their workload. Public home care services were invaluable to caregivers’ maintaining their loved ones at home. Caregivers were inventive in finding sources of hope and quality of life for their loved ones.Conclusion:Publicly funded home care was essential for caregivers of PwMSA in this study. Caregiver support is needed to provide this unrecognized workforce with information and resources to face this challenging condition.
Spatial variability and regional trends of Antarctic ice shelf surface melt duration over 1979–2020 derived from passive microwave data
Authors: Johnson Andrew , Hock Regine , Fahnestock Mark 
Published: November 2021

AbstractPassive microwave satellite observations are used to identify the presence of surface meltwater across Antarctica at daily intervals from July 1979 to June 2020, with a focus on ice shelves. Antarctic Peninsula ice shelves have the highest number of annual days of melt, with a maximum of 89 days. Over the entire time period, there are few significant linear trends in days of melt per year. High melt years can be split into two distinct categories, those with high melt days in Dronning Maud Land and Wilkes Land, and those with high melt days in the Antarctic Peninsula and the Bellingshausen Sea sector of West Antarctica. The first pattern coincides with significant negative correlations between melt days and spring and summer Southern Annular Mode. Both patterns also form the primary modes of spatial and annual variability in the dataset observed by Principal Component Analysis. Areas experiencing extended melt for the first time in years tend to show large decreases in subsequent winter microwave emissions due to structural changes in the firn. We use this to identify the impact of novel melt events, particularly over the austral summers of 1991/92 and 2015/16 on the Ross Ice Shelf.
Faunal composition and paleoenvironmental reconstruction of a Middle–Late Triassic boundary assemblage in the Pyrenean basin (Catalonia, NE Spain)
Authors: Garcia-Artigas Ruben , Mercedes-Martín Ramon , Cartanyà Joan , Bolet Arnau , Riccetto Marc , Fortuny Josep 
Published: November 2021

AbstractThe Ladinian–Carnian transition in the Tethys domain was accompanied by an important environmental change representing a milestone in the climate evolution of the Triassic. However, estimations on paleodiversity composition and paleoenvironmental conditions across this interval are scarce in marine settings due to the lack of fossil-bearing successions. In this work, a refined paleontological and sedimentological study has allowed us to better characterize a well-preserved marine ?Ladinian–Carnian carbonate succession in the South Central Pyrenees (Odèn site, Catalonia, NE Spain). Vertebrate faunas include numerous actinopterygian specimens, forming an assemblage composed of at least four taxa:Peltopleuruscf.P. nuptialisLombardo, 1999,Saurichthyssp.,Colobodus giganteus(Beltan, 1972), and an indeterminate halecomorph. Specimens belonging to the genusPeltopleurusare dominant; the long-snoutedSaurichthys, the halecomorph, and the large-bodiedColobodus giganteusare less abundant. Tetrapod remains are scarcely present and are assigned to sauropterygians. Invertebrate faunas include bivalves (Pseudocorbula gregaria[Münster in Goldfuss, 1838]) and brachiopods (Lingulasp.). The fossil assemblage was recovered from organic-rich laminated silty mudstone layers. Sedimentological and textural analyses suggest that fossil biotas were deposited below the fair-weather wave base in shallow subtidal coastal settings. These environments were sporadically sourced by silt/clay. The age of the Odèn site, on the basis of the recovered fauna, is assigned to the ?late Ladinian–middle Carnian (Middle–Late Triassic), which is in agreement with previously published ages based on palynomorph data.The refined integration of paleontological, sedimentological, and biostratigraphic data from the Odèn site and other vertebrate-bearing localities in the Tethys domain can help better constrain the paleoenvironmental conditions and paleogeographical configuration impacting ecosystem diversity during the late Ladinian–Carnian interval.
Self-protection as an adaptive female strategy
Authors: Benenson Joyce F. , Webb Christine E. , Wrangham Richard W. 
Published: November 2021

AbstractMany male traits are well explained by sexual selection theory as adaptations to mating competition and mate choice, whereas no unifying theory explains traits expressed more in females. Anne Campbell's “staying alive” theory proposed that human females produce stronger self-protective reactions than males to aggressive threats because self-protection tends to have higher fitness value for females than males. We examined whether Campbell's theory has more general applicability by considering whether human females respond with greater self-protectiveness than males to other threats beyond aggression. We searched the literature for physiological, behavioral, and emotional responses to major physical and social threats, and found consistent support for females' responding with greater self-protectiveness than males. Females mount stronger immune responses to many pathogens; experience a lower threshold to detect, and lesser tolerance of, pain; awaken more frequently at night; express greater concern about physically dangerous stimuli; exert more effort to avoid social conflicts; exhibit a personality style more focused on life's dangers; react to threats with greater fear, disgust, and sadness; and develop more threat-based clinical conditions than males. Our findings suggest that in relation to threat, human females have relatively heightened protective reactions compared to males. The pervasiveness of this result across multiple domains suggests that general mechanisms might exist underlying females' unique adaptations. An understanding of such processes would enhance knowledge of female health and well-being.
Assembling ‘indigeneity’ through musical practices: translocal circulations, ‘tradition’, and place in Otavalo (Ecuadorian Andes)
Authors: Voirol Jérémie 
Published: November 2021

AbstractThis article addresses the relation between Andean ‘traditional music’ and circulations of people, objects, ideas and sounds. Although many studies on Andean indigenous music have explored such circulations, scholars still tend to understand musical practices in terms of ‘cultures’. The case of indigenous music from Otavalo, in the Ecuadorian Andes, encourages us to go beyond this approach. I make two arguments. First, by conceiving of the translocal/transnational flows that have shaped ‘traditional music’ from Otavalo through the concepts of ‘network’ and ‘music world’, I unsettle the link – underlying previous approaches – between a specific people, music and place. Second, through the concepts of ‘assemblage’ and ‘mediation’, I closely look at processes of ‘traditionalisation’ and ‘indigenisation’ to show how, in the context of multiple circulations, social actors nevertheless produce a specific link between people, music and place in order to make a musical practice ‘traditional’ and/or ‘indigenous’.
Integration of a Palliative Approach in the Care of Older Adults with Dementia in Primary Care Settings: A Scoping Review
Authors: Vellani Shirin , Puts Martine , Iaboni Andrea , Degan Christine , McGilton Katherine S. 
Published: November 2021

AbstractA palliative approach to care aims to meet the needs of patients and caregivers throughout a chronic disease trajectory and can be delivered by non-palliative specialists. There is an important gap in understanding the perspectives and experiences of primary care providers on an integrated palliative approach in dementia care and the impact of existing programs and models to this end. To address these, we undertook a scoping review. We searched five databases; and used descriptive numerical summary and narrative synthesizing approaches for data analysis. We found that: (1) difficulty with prognostication and a lack of interdisciplinary and intersectoral collaboration are obstacles to using a palliative approach in primary care; and (2) a palliative approach results in statistically and clinically significant impacts on community-dwelling individuals, specifically those with later stages of dementia. There is a need for high-quality research studies examining the integrated palliative approach models and initiation of these models sooner in the care trajectory for persons living with mild and moderate stages of dementia in the community.
Inferring the COVID-19 infection fatality rate in the community-dwelling population: a simple Bayesian evidence synthesis of seroprevalence study data and imprecise mortality data
Authors: Campbell Harlan , Gustafson Paul 
Published: November 2021

Abstract
Estimating the coronavirus disease-2019 (COVID-19) infection fatality rate (IFR) has proven to be particularly challenging –and rather controversial– due to the fact that both the data on deaths and the data on the number of individuals infected are subject to many different biases. We consider a Bayesian evidence synthesis approach which, while simple enough for researchers to understand and use, accounts for many important sources of uncertainty inherent in both the seroprevalence and mortality data. With the understanding that the results of one's evidence synthesis analysis may be largely driven by which studies are included and which are excluded, we conduct two separate parallel analyses based on two lists of eligible studies obtained from two different research teams. The results from both analyses are rather similar. With the first analysis, we estimate the COVID-19 IFR to be 0.31% [95% credible interval (CrI) of (0.16%, 0.53%)] for a typical community-dwelling population where 9% of the population is aged over 65 years and where the gross-domestic-product at purchasing-power-parity (GDP at PPP) per capita is $17.8k (the approximate worldwide average). With the second analysis, we obtain 0.32% [95% CrI of (0.19%, 0.47%)]. Our results suggest that, as one might expect, lower IFRs are associated with younger populations (and may also be associated with wealthier populations). For a typical community-dwelling population with the age and wealth of the United States we obtain IFR estimates of 0.43% and 0.41%; and with the age and wealth of the European Union, we obtain IFR estimates of 0.67% and 0.51%.
Comparison of Doty and McGoon techniques for surgical reconstruction of congenital supravalvular aortic stenosis
Authors: Biçer Mehmet , Dedemoğlu Mehmet , Korun Oktay , Altın Hüsnü F. , Yurdakök Okan , Çiçek Murat , Özdemir Fatih , Selçuk Arif , Altuntaş Yasemin , Yücel Ilker K. , Şaşmazel Ahmet , Aydemir Numan A. 
Published: November 2021

AbstractBackground:We aimed to compare the results of two surgical methods for the treatment of congenital supravalvular aortic stenosis.Methods:From May 2004 to January 2020, 29 patients underwent surgical repair for supravalvular aportic stenosis in a single centre. The perioperative evaluation of the patients was retrospectively reviewed.Results:Fifteen (51.7%) and 14 (48.2%) patients were treated with the Doty and the McGoon methods, respectively. The median age of our cohort was 4.5 (3.0–9.9) years. Ten (34.5%) patients had Williams–Beuren syndrome, and pulmonary stenosis was observed in 12 (41.3%) patients. The median follow-up time was 2.5 (0.7–7.3) years. On follow-up, five patients had residual stenosis with the McGoon technique and one with the Doty technique (p = 0.05). One patient died early in the post-operative period in the Doty group, and three patients were re-operated on due to restenosis in the McGoon group. Freedom from re-operation in the Doty group at 1, 3, 5, and 10 years was 100%. In the McGoon group, freedom from re-operation rates at the 1-, 3-, and 7-year follow-up were 100, 88.9, and 44.4%, respectively (p = 0.08).Conclusion:Our results with both surgical techniques suggest that supravalvular aortic stenosis can be treated with good results. The Doty method provided better relief for the supravalvular aortic segment, considering the residual stenosis and the re-operation rates.
The role of international humanitarian law in the search for peace: Lessons from Colombia
Authors: Rojas-Orozco César 
Published: November 2021

AbstractInternational humanitarian law (IHL) has traditionally been seen as a legal framework regulating armed hostilities, having little to do with peace. However, recent peacemaking and peacebuilding practice has consistently relied on IHL to frame peace efforts, mainly in non-international armed conflicts. This article explores the relationship between IHL and peace, looking at practice in Colombia, where IHL has been used in a creative way as a means to build trust, facilitate peace negotiations and enforce the resulting peace agreement. Looking at this case, the article offers general insights on how IHL can facilitate the end of conflict and reintegration, frame accountability and reparation, and shield peace deals under a framework in which both State and non-State actors can find a common bargaining zone in their search for peace.