bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kherzet Youcef Mine Flooding of 2nd June 1990 Revisited (Northeastern of Algeria) Origine and Hydrogeological Consequences
Authors: Souhila CHEDDAD , Abdelhamid Haouchine 
Published: November 2021

Abstract
This work is part of the hydrogeological study of the Kherzet Youcef deposit. The polymetallic deposit of Kherzet Youcef, known, since the beginning of the 20th century, by the exploitation of Lead and Zinc ore, is located 50 Km southeast of Setif (North-eastern Algeria) and 5.5 Km west of Ain Azel. Mineralization is represented by some ore bodies (about 25). The thickness variate from a few centimeters up to 3m. These bodies are located on the layers of dolomites and dolomitized marls and along the Kherzet Youcef fault. The geological reserves of Zinc and Lead ore are of the order of 1.6 million tons. This ore has a Pb content of 3.6% and Zn content of 18.4%. The projected annual exploitation was 100 thousand tons per year. Hydrogeological studies carried out successively (1973-1977) and (1981-1983) revealed the existence of an aquifer system located west of the Kherzet Youssef fault characterized by the presence of Karts and by strong cracking due to local brittle tectonics. These two characteristics define the filtration and storage capacity of very abundant groundwater. This groundwater represented a major handicap for mining in view of the large amounts of water that required the installation of major pumping and drainage devices. The Kherzet Youssef mine has experienced frequent flooding in the past at a time when technology could not pump efficiently. It caused the mine to close several times. In June 1990, the mine experienced a flood of great magnitude that has never been observed and despite the large installed means of pumping, this "water cost" led to the total drowning of the mine, the death of 19 workers and the stoppage of the exploitation of this deposit since. Pitting attempts were carried out with a pumping capacity of 1100 m3/h, then 1800 m3/h but without success. The interpretation of the drawdown data and field observations made it possible to conclude that this accident was only the result of the general destabilization of the massif. Our complementary work by geophysical prospecting made it possible to represent the configuration of the underground layers and demonstrate the hydrodynamic communication between the two East and West compartments of the deposit.
The Dynamic Lattice Method - Vibrations and Wave Propagation in Discontinuous and Heterogeneous Media
Authors: Sattari Amir Shoarian , Rizvi Zarghaam H. , Aji Hendrawan D. B. , Wuttke Frank 
Published: November 2021

Abstract
The development of a new dynamic lattice element method (dynamicLEM) as well as its application in the simulation of wave propagation in discontinuous and heterogeneous media is the focus of this research paper. The conventional static lattice models are efficient numerical methods to simulate crack initiation and propagation in cemented geomaterials. The advantage of the LEM and the developed dynamic solution, such as simulation of arbitrary crack initiation and propagation, illustration and simulation of existing inherent material heterogeneity as well as stress redistribution upon crack opening, opens a new engineering field and tool for material analysis. To realize the time dependency of the dynamic LEM, the governing Newton's second law is solved while using the Newmark-β method and implementing the non-linear Newton-Raphson Jacobian. The method validation is done according to the results of a boundary element method (BEM) in the plane P-SV-wave propagation within a plane strain domain. Further validation tests comparing the generated wave types, simulation and study of crack discontinuities as well as inherent heterogeneities in the geomaterials are conducted to illustrate the accurate applicability of the new dynamic lattice method. The results indicate that with increasing heterogeneity within the material, the wave field becomes significantly scattered and further analysis of wave fields according to the wavelength/heterogeneity ratio become indispensable. Therefore, in a heterogeneous medium, the application of continuum methods in relation to structural health monitoring should be precisely investigated and improved. The developed dynamic lattice element method is an ideal simulation tool to consider particle scale irregularities, crack distributions and inherent material heterogeneities and can be easily implemented in various engineering applications.
InflamNat: Web-Based Database and Predictor of Anti-Inflammatory Natural Products
Authors: Zhang Ruihan , Ren Shoupeng , Dai Qi , Shen Tianze , Li Xiaoli , Li Jin , Xiao Wei-Lie 
Published: November 2021

Abstract
Natural products (NPs) are a valuable source for anti-inflammatory drug discovery. However, they are limited by the unpredictability of the structures and functions. Therefore, computational and data-driven pre-evaluation could enable more efficient NP-inspired drug development. Since NPs possess structural features that differ from synthetic compounds, models trained with synthetic compounds may not perform well with NPs. There is also an urgent demand for well-curated databases and user-friendly predictive tools. We presented a comprehensive online web platform (InflamNat, http://www.inflamnat.com/ or http://39.104.56.4/) for anti-inflammatory natural product research. InflamNat is a database containing the physicochemical properties, cellular anti-inflammatory bioactivities, and molecular targets of 1351 NPs that tested on their anti-inflammatory activities. InflamNat provides two machine learning-based predictive tools specifically designed for NPs that (a) predict the anti-inflammatory activity of NPs, and (b) predict the compound-target relationship for compounds and targets collected in the database but lacking existing relationship data. A novel multi-tokenization transformer model (MTT) was proposed as the sequential encoder for both predictive tools to obtain a high-quality representation of sequential data. Experimental results demonstrated that the proposed predictive tools achieved the desired performance in terms of AUC.
GMCSF modulates Myeloid derived suppressor cells and Tregs activity in decompensated cirrhotic patients with sepsis
Authors: Sehgal Rashi , Maiwall Rakhi , Rajan Vijayraghavan , Islam Mojahidul , Baweja Sukriti , Kaur Navkiran , Kumar Guresh , Ramakrishna Gayatri , Sarin Shiv Kumar , Trehanpati Nirupma 
Published: November 2021

Abstract
Background

Decompensated cirrhosis patients are more prone to bacterial infections. Myeloid derived suppressor cells (MDSCs) expand in sepsis patients and disrupt immune cell functions. GM-CSF therapy helps in restoring immune cell functions and resolve infections. Its role in MDSCs modulation in cirrhotic with sepsis is not well understood.
Methods

164 decompensated cirrhotic; 62 without(w/o), 72 with sepsis and 30 with sepsis treated with GM-CSF and 15 healthy were studied. High-dimensional flow cytometry was performed to analyse MDSCs, monocytes, neutrophils, CD4 T-cells and Tregs at admission, day3 and 7. Ex-vivo co-cultured MDSCs with T-cells were assessed for proliferation and apoptosis of T-cells, differentiation to T-regs. Plasma factors and mRNA levels were analysed by cytokine-bead assay and qRT-PCR.
Results

Frequency of MDSCs and T-regs were significantly increased (p=0.011, and p=0.02) with decreased CD4 T-cells(p=0.01) in sepsis than without sepsis and HC (p=0.000, p=0.07 and p=0.01) at day0, and day7. In sepsis patients, MDSCs had increased IL-10, Arg1 and iNOS mRNA levels (p=0.016, p=0.049 and p=0.06). Ex-vivo co-cultured MDSCs with T-cells drove T-cell apoptosis (p=0.03, p=0.03) with decreased T-cell proliferation and enhanced FOXP3+ expression (p=0.05 and p=0.05) in sepsis compared to no sepsis at day0. Moreover, blocking the MDSCs with inhibitors suppressed FOXP3 expression. GM-CSF treatment in sepsis patients significantly decreased MDSCs and FOXP3+Tregs but increased CD4 T-cell functionality and improved survival.
Conclusion

MDSCs have immunosuppressive function by expanding FOXP3+ Tregs and inhibiting CD4+ T-cell proliferation in sepsis. GM-CSF treatment suppressed MDSCs, improved T-cell functionality and reduced Tregs in circulation.
Identification of G6PC As A Potential Prognostic Biomarker In Hepatocellular Carcinoma Based On Bioinformatics Analysis
Authors: Li Tian , Yong Liao 
Published: November 2021

Abstract
Background: Hepatocellular carcinoma (HCC) has high mortality and incidence rates around the world with limited therapeutic options, there is an urgent need for identification of novel therapeutic targets and biomarkers for early diagnosis and predicting patient survival with HCC. Methods: Several studies (GSE102083, GSE29722, GSE101685 and GSE112790) from the GEO database in HCC were screened and analyzed by GEO2R, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were conducted with the Database for Annotation, Visualization and Integrated Discovery (DAVID). The protein-protein interaction network (PPI) was plotted and the module analysis was performed using Search Tool for the Retrieval of Inter-acting Genes/Proteins database (STRING) and Cytoscape. The expression and survival of key genes were identified using UALCAN, Kaplan-Meier Plotter and ONCOMINE online databases, and the immune infiltration level of key genes was analyzed via TIMER database. Results: Eight key genes were finally screened out through several database analysis, and UALCAN was used to detect the expressions of CKS2 and G6PC, which were closely related to the survival of HCC patients. Further analysis on the differential expression of G6PC in multiple cancerous tumors and normal tissues revealed low expression in many solid tumors by Oncomine and TIMER. In addition, Kaplan-Meier plotter and UALCAN database analysis to access diseases prognosis suggested that low expression of G6PC was significantly associated with poor overall survival in HCC patients. Finally, TIMER database analysis showed a significant negative correlation between G6PC and infiltration levels of six kinds of immune cells. The somatic copy number alterations (SCNAs) of G6PC were associated with B cells, CD8+ T cells, CD4+ T cells, macrophages, dentritic cells and neutrophils. Conclusions: These bioinformatic data identified G6PC as a potential key gene in the diagnosis and prognosis of HCC.
Comparison of Allogenic and Autogenic Implantations of Dedifferentiated Fat Cells On Monoclonal Antibody 1-22-3-Induced Glomerulonephritis in Rats
Authors: Maruyama Takashi , Fukuda Noboru , Matsumoto Taro , Endo Morito , Utsunomiya Kei , Shimizu Satoshi , Kano Koichiro , Abe Masanori 
Published: November 2021

Abstract
Background
We established an adipogenic progenitor cell line derived from mature adipocytes and named these cells dedifferentiated fat (DFAT) cells, which have been shown to have characteristics very similar to those of mesenchymal stem cells (MSCs). The potential application of DFAT cells to support cell-based therapies for regenerative and immunosuppressive therapies has been suggested. The present study was designed to address beneficial ways that DFAT implantation can be used clinically as immunosuppressive therapy to treat immunological glomerulonephritis.
Methods
We evaluated distribution of DFAT cells after intravenous injection through the tail vein in Wistar rats. We examined effects of allogenic implantation of DFAT cells on BrdU incorporation into kidney from rats with monoclonal antibody (mAb) 1-22-3-induced glomerulonephritis. We compared effects of allogenic and autogenic implantations of DFAT cells on excretion of urinary protein, renal function, and glomerular and nephrotubular injuries in these rats, and serum levels of tumor necrosis factor-stimulated gene-6 (TSG-6), and expression of TSG-6 mRNA in kidney.
Results
The allogenic implantations of DFAT cells trapped in lung improved excretion of urinary protein and renal function, and significantly suppressed glomerular and nephrotubular injuries in the rats with mAb1-22-3-induced glomerulonephritis compared with the autogenic implantations. The allogenic implantation of DFAT cells increased serum levels of TSG-6 especially in mAb 1-22-3-induced glomerulonephritis and significantly increased the expression of TSG-6 mRNA in kidney compared to the autogenic implantation.
Conclusion
These findings suggest that allogenic implantation of DFAT cells could be clinically useful immunosuppressive therapy for immunological glomerulonephritis.
Mechanical and Radiation Shielding properties of CuO doped TeO2-B2O3 Glass System
Authors: NIDZAM NAZIRUL NAZRIN SHAHROL , Sharma Amandeep , Jufa M.S. , Izzaty M.K. , Boukhris Imed 
Published: November 2021

Abstract
A series of borotellurite glass system doped with copper oxide was synthesized using the method of melt quenching. The density of the glass decreases whereas its molar volume increases in respect to copper oxide concentration. The amorphous nature of prepared glasses was proven with the utilisation of XRD spectra. Meanwhile, the glass samples’ elastic properties are determined from the measurement of longitudinal and shear velocities using ultrasonic technique. The longitudinal modulus, shear modulus, bulk modulus and Young’s modulus will show an irregular trend that fluctuates. FLUKA Monte Carlo code is implemented to determine the shielding features at gamma energy 0.3565, 0.6616, 0.8348 and 1.3325 MeV. Linear attenuation coefficients acquired from FLUKA and XCOM are found to be in good agreement with relative difference < 1%. The glass sample B2O3TeO2CuO1 (with highest percentage of TeO2) is found to be the best shielding glass material in this study.
Mitochondrial DNA and Alzheimer's Disease: A First Case-control Study of the Tunisian Population
Authors: Salem Nesrine Ben , Boussetta Sami , de Rojas Itziar , Moreno-Grau Sonia , Montrreal Laura , Mokni Narjes , Mahmoud Imene , Younes samia , Daouassi Nizar , Frih-Ayed Mahbouba , Hammami Afef , Elgaaied Amel Ben Ammar , Ruiz Agustín , Cherni Lotfi 
Published: November 2021

Abstract
Background: Alzheimer’s disease (AD) is the most common neurodegenerative disorder in humans and presents a major health problem throughout the world. The etiology of AD is complex, and many factors are implicated, including mitochondria. Mitochondrial alteration has been proposed as a possible cause of AD Therefore, several studies have focused on finding an association between inherited mitochondrial DNA variants and AD onset.Methods: In this study, we looked, for the first time, for a potential association between mitochondrial haplogroups or polymorphisms and AD in the Tunisian population. We also evaluated the distribution of the major genetic risk factor for AD, the apolipoprotein E epsilon 4 (APOE ε4), in this population. In total, 159 single-nucleotide polymorphisms (SNPs) of mitochondrial DNA haplogroups were genotyped in 254 individuals (58 patients and 196 controls). An additional genotyping of APOE ε4 was performed.Results: No significant association between mitochondrial haplogroups and AD was found. However, two individual SNPs, A5656G (p = 0.03821, OR = 10.46) and A13759G (p = 0.03719, OR = 10.78), showed a significant association with AD. APOE 4 was confirmed as a risk factor for AD (p = 0.000014). Conclusion: Our findings may confirm the absence of a relation between mitochondrial haplogroups and AD and support the possible involvement of some inherited variants in the pathogenicity of AD.
No Association of Eight TNFAIP3 Single Nucleotide Variants to Rheumatoid Arthritis in Native Mexicans
Authors: Aranda-Uribe Iván Sammir , Ramírez-Bello Julián , Victoria-Acosta Georgina , Barbosa-Cobos Rosa Elda , Moreno José 
Published: November 2021

Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease of autoimmune origin associated with many genetic traits, including genes related to the control of inflammation. The A20 protein, encoded by the TNFAIP3 gene, is a negative regulator of NF-kB-mediated inflammation. Several single nucleotide variants (SNVs) of TNFAIP3 are associated with susceptibility to RA in different ethnic groups, but not in Chileans, the only Latin Americans studied thus far. Objective. To examine the association of eight TNFAIP3 SNVs, four of them not previously studied, with RA in Mexican patients. Materials . We studied 471 RA patients (ACR-EULAR 2010) and eight TNFAIP3 SNVs: including, rs10499194C/T, rs6920220G/A and rs2230926T/G, which are associated with RA in European and Asian patients, in addition to rs373421182G/C, rs139054966T/G, rs5029924C/T, rs59693083A/G and rs61593413T/A, not previously examined in RA. All SNVs were evaluated by means of an allelic discrimination assay and TaqMan probes. Results. The allelic and genotypic frequencies of all SNVs examined were similar between cases and controls, and none of them was associated with RA under the allelic, codominant, dominant, and recessive models was observed. Conclusion. Our data indicate that the TNFAIP3 SNVs evaluated herein are not risk factors for RA in Mexican subjects.
Grain yield stability analysis using AMMI and GGE biplot models in different breeding zones of Bangladesh
Authors: Khatun Marium , Islam A. K. M. Aminul , Islam M. Rafiqul , Khan M. A. Rahman , Hossain M. Kamal 
Published: November 2021

Abstract
During the 2018-2019 Boro season (dry season), 70 rice genotypes were examined with alpha lattice experimental design with the goal of measuring grain yield stability analysis. Results indicated that AMMI analysis explained 100% of the G×E variance, while captured 81.74% variance. Based on the GGE and AMMI analysis, the most stable and high yielding genotype was identified G41 followed by G22, G26, G58, G24 and G61. The AMMI 1 biplot analysis revealed that the first primary component of interaction (IPC1) factor was responsible for 64.2 % variation due to G × E interaction. On other hand, the second primary component (PC2) factor accounted for 35.8% variation of the G × E interaction. These two-primary component (PC1 and PC2), all together accounted for 100% variation of the G × E interaction. The contribution of G68 was highest to the interaction followed by G70, G58, G42, G61, G45, G38, G14, G33, G60, G53, and G9. Best environment analysis indicated that the ranking was Rajshahi < Gazipur < Cumilla. GGE biplot analysis accounted for 81.74% variation comprising two principal components PC1 and PC2 with 45.62% and 36.12% variations respectively. Rajshahi was more stable than Gazipur. Based on environment analysis genotypes, G22, G26, G58, and G44 can be recommended as best stable genotypes that breeding zone. However, the genotype G61 was identified adapted to Cumilla breeding zone.
Comparison Efficacy of Ultrasound-Guided Needle Release Plus Corticosteroid Injection and Mini-Open Surgery in Patients with Carpal Tunnel Syndrome
Authors: Zeng Zeng , Lin Nan , Chen Cong-Xian 
Published: November 2021

Abstract
This retrospective study was to compare clinical outcomes of ultrasound-guided needle release with corticosteroid injection versus mini-open surgery in patients with carpal tunnel syndrome (CTS). From January 2020 to December 2020, 40 patients (40 wrists) with CTS were analyzed in this study. Diagnosis was based on clinical symptoms, electro-physiological and ultrasound imaging. 20 wrists were treated with ultrasound-guided needle release plus corticosteroid injection (Group A) and other 20 wrists went mini-open surgery (Group B). We evaluated Boston carpal tunnel questionnaire, electrophysiological parameters (distal motor latency, sensory conduction velocity and sensory nerve action potential of median nerve) and ultrasound parameters (cross-sectional area, flattening ratio and the thicknesses of transverse carpal ligament) both before and 3 months after treatment. Total treatment cost, duration of treatment, healing time and complications were also recorded for two groups. Boston carpal tunnel questionnaire, electrophysiologic and ultrasound outcomes at preoperatively and 3 months postoperatively had significant difference for each group (each P༜0.05). There were no complications such as infection, haemorrhage, vascular, nerve or tendon injuries in both groups. Ultrasound-guided needle release and mini-open surgery are both effective measures in treating CTS patients. Ultrasound-guided needle release plus corticosteroid injection provides smaller incision, less cost, less time of treatment and faster recovery compared with mini-open surgery. Ultrasound-guided needle release plus corticosteroid injection is better for clinical application.
An Immune Algorithm Based on Entropy For Computing Offloading Problem in Edge Computing Scenes
Authors: Sifeng ZHU , Jianghao CAI , Enlin SUN , Qinghua ZHANG 
Published: November 2021

Abstract
By offloading computing tasks to the edge of mobile network, mobile edge computing(MEC) solves the shortcomings of mobile devices in computing capacity and storage capacity. In order to reduce the computing delay of mobile terminal devices and the degree of workload balancing in MEC servers, a computing offloading solution based on information entropy immune algorithm is proposed. Firstly, the system model, delay model, load model and objective optimization model are constructed. Then, a task offloading scheme based on immune optimization is proposed .Finally, this scheme is compared with the Benchmark scheme and the offloading scheme in the literature. Simulation experiments show that the proposed scheme can effectively reduce the average offloading delay, and can effectively balance the load between MEC servers. At the same time, compared with the schemes in the literature, the performance of the scheme is improved to a certain extent.
Hypothalamic neurochemical changes in long-term recovered bilateral subdiaphragmatic vagotomized rats
Authors: Kobrzycka Anna Teresa , Stankiewicz Adrian Mateusz , Goscik Joanna , Gora Monika , Burzynska Beata , Iwanicka-Nowicka Roksana , Pierzchala-Koziec Krystyna , Wieczorek Marek 
Published: November 2021

Abstract
BackgroundVagus nerve is one of the crucial routes in communication between immune and central nervous systems. Impaired vagal nerve function may intensify peripheral inflammatory processes. This effect subsides along with prolonged recovery after permanent nerve injury. One of the results of such compensation is a normalized plasma concentration of stress hormone corticosterone – a marker of hypothalamic-pituitary-adrenal (HPA) axis activity. In the present work we strive to explain this corticosterone normalization by studying the mechanisms responsible for compensation-related neurochemical alterations in the hypothalamus. Methods Using microarrays and HPLC we measured genome-wide gene expression and major amino acid neurotransmitters content in hypothalamus of bilaterally vagotomized rats, one month after surgery.ResultsOur results show that, in the long-term, vagotomy affects hypothalamic amino acids concentration but not mRNA expression of tested genes.ConclusionsWe propose an alternative pathway of immune to CNS communication after vagotomy, leading to activation of HPA axis, by influencing central amino acids and subsequent monoaminergic neurotransmission.