bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Different Sarcopenia Stages on the Postoperative New Osteoporotic Vertebral Compression Fracture After Percutaneous Kyphoplasty
Authors: Lin Chaowei , Zhu Minyu , Huang Kelun , Lu Sheng , Teng Honglin 
Published: January 2021

Abstract
PurposeThe purpose of this study was to evaluate the impact of different sarcopenia stages on osteoporotic vertebral compression refracture (OVCRF) and identify other risk factors of new osteoporotic vertebral compression fracture (OVCF).MethodsWe conducted a large, retrospective study of patients who underwent percutaneous kyphoplasty (PKP) for OVCF. Sarcopenia was staged as “presarcopenia”, “sarcopenia”, and “severe sarcopenia” according to the definition of the European Working Group on Sarcopenia in Older People. Univariate and multivariate analyses evaluating the risk factors for OVCRF were performed. ResultsA total of 329 patients were included, in which 20.4%, 13.1%, and 7.3% of the patients were identified as having “presarcopenia”, “sarcopenia”, and “severe sarcopenia” respectively. Advanced sarcopenia stage was associated with lower BMI, lower serum albumin level and higher NRS 2002 scores. Subsequent fractures developed in 72 (21.8 %) of 329 patients during the one year follow-up. In univariate analysis, female (p = 0.012), advanced age (≥ 75 years; p = 0.004), lower BMD (p =0.000), stage of sarcopenia (p = 0.009) were associated with OVCRFs. Multivariable analysis revealed that female (OR 6.325; 95% CI 2.176-18.368, p = 0.001), age (OR 1.863; 95% CI 1.002-3.464, p =0.049), lower BMD (OR 1.736; 95% CI 1.294-2.328, p = 0.000), sarcopenia (OR 2.536; 95% CI 1.130-5.692, p = 0.024) and severe sarcopenia (OR 4.579; 95% CI 1.615-12.968, p = 0.004) were independent risk factors of OVCRFs. ConclusionsSarcopenia and severe sarcopenia were independent risk factors for OVCRF, as well as low BMD, advanced age and female.
Association between Smoking and In-hospital mortality in Patients with Left Ventricular Dysfunction Undergoing Coronary Artery Bypass Surgery: A Propensity-matched Study
Authors: Tang Hanwei , Hou Jianfeng , Chen Kai , Huang Xiaohong , Liu Sheng , Hu Shengshou 
Published: January 2021

Abstract
BackgroundData on the effect of smoking on In-hospital outcome in patients with left ventricular dysfunction undergoing coronary artery bypass graft (CABG) surgery are limited. We sought to determine the influence of smoking on CABG patients with left ventricular dysfunction.MethodsA retrospective study was conducted using data from the China Heart Failure Surgery Registry database. Eligible patients with left ventricular ejection fraction less than 50% underwent isolated CABGS were included. In addition to the use of multivariate regression models, a 1 to 1 propensity scores matched analysis was performed. Our study (n=6,531) consisted of 3,635 smokers and 2896 non-smokers. Smokers were further divided into ex-smokers (n=2373) and current smokers (n=1262).ResultsThe overall in-hospital morality was 3.9%. Interestingly, current smokers have lower in-hospital mortality than non-smokers (2.3% vs 4.9%; adjusted odds ratio [OR], 0.612 [95%CI, 0.395-0.947]). No difference was detected in mortality between ex-smokers and non-smokers (3.6% vs 4.9%; adjusted OR, 0.974 [0.715-1.327]). No significant differences in other clinical end points were observed. Results of propensity-matched analyses were broadly consistent.ConclusionsIt is paradoxically that current smokers had lower in-hospital mortality than non-smokers. Future studies should be performed to further understand the biological mechanisms that may explain this ‘smoker’s paradox’ phenomenon.
Fabrication of GaN&nbsp;Nano-towers Based Self-powered UV&nbsp;Photodetector
Authors: Goswami Lalit , Aggarwal Neha , Vashishtha Pargam , Jain Shubhendra , Nirantar Shurti , Ahmed Jahangeer , Khan M A Majeed , Pandey Rajeshwary , Gupta Govind 
Published: January 2021

Abstract
Fabrication of unique tapper ended GaN-Nanotowers structure based highly efficient ultraviolet photodetector is demonstrated. Hexagonal stacked GaN nanocolumnar structure (nanotowers) grown on AlN buffer layer exhibits higher photocurrent generation which significantly enhances its responsiveness towards ultraviolet illumination and leads to outstanding performance of the device. The fabricated detector display low dark current (~12nA), high ILight / IDark ratio (>104), fast time-correlated transient response (~433µs) upon UV (325nm) illumination. A very high photo responsivity of 2.47 A/W in self-powered (zero applied bias) mode of operation is reported. While in photoconductive mode, the responsivity is observed to be 35.4 A/W @ -3V alongwith very high external quantum efficiency (~104 %), lower noise equivalent power (~10-13 WHz-1/2) and excellent UV-Vis selectivity. Nanotower structure with lower strain and dislocations as well as reduced trap states cumulatively contributed to augmented performance from the device. The utilization of these GaN-Nanotower structures can potentially be useful towards the fabrication of energy-efficient ultraviolet photodetector.
WITHDRAWN: Systematic prompting the new physiological and morphological, biological responses of&nbsp;modified metabolic induction process of Calendula officinalis L under heat stress with couple of supplementary&nbsp;nutritional applications as safety of floriculture crops
Authors: ahmed waseem , Azmant Rafia , Qayyum Abdul , Mehmood Ayaz , Ahmed Rasheed 
Published: January 2021

Abstract
Purpose
the objective of study to modified the metabolism of Calendula officinalis L. under heat stress couple with N and P application in two years of study.
Methods
the trail was conducted during peak summer season (months of May, June, and July) couple with different levels of N & P application to monitor the quality and quantity characterization of marigold (Calendula officinalis L.). The traits of three doses of N and P (0.6 g, 0.9 g, and 0.8 g, 1− 1 g) given to Calendula officinalis L.) to display the vegetative, reproductive, physiological parameters such as Malondialdehyde (MDA), Chlorophyll contents, Lipid Peroxidation Assay in leaves, Li and K contents, phytochemicals and nitrogen and phosphorus used efficacy
Results
showed that maximum values of Malondialdehyde (MDA), Chlorophylls, Lipid Peroxidation Assay in leaves observed followed by the alteration in Li and K measured in the month of May, June with slight differences July. The phytochemicals like total phenolic contents (84.41 mg GAE/g), total antioxidants (36.3% DPPH), total carotenoids and total flavonoids contents (16.2 and 0.9 mg/100 g) were measured by 0.9 g of Nitrogen application and followed by 1 g of Phosphorus in both years of study. The respirational changes were observed in the higher rate of P levels. The liner changes of N and P rates showed some fluctuation in heat stress months.
Conclusions
It was concluded that the higher doses of both N and P fertilizers were effective in controlling the heat stress and mentioned the quality of florets by various induction and biological active process.
Development of a Novel Immune-Related Prognostic Signature for Prostate Cancer
Authors: Hong Cheng , Chen Ming , Yi Wang , Jianping Wu , Jibo Jing , Tiange Wu , Shuqiu Chen 
Published: January 2021

Abstract
Purpose: Prostate cancer (PCa) has a high incidence in older men. In the field of tumor immunology therapy, there are no strong characteristics to predict the survival of PCa in tumor immunology. Therefore, it is necessary to explore the characteristics of PCa in immunology.Methods: In this study, RNA-seq and clinical data of 499 PCa tissue samples and 52 normal tissue samples were obtained from The Cancer Genome Atlas (TCGA). Finally, 193 differentially expressed immune-related genes (IRGs) between PCa and normal prostate tissues were identified based on TCGA. Functional enrichment analyses showed that immunology may act in a tumor-suppressive role in the initiation of Pca, and then we identified different expressed transcription factors (TFs) and construction of the correlation network between TFs and IRGs. Univariate Cox analysis and multivariate Cox regression analysis were performed to identify 5 key prognostic IRGs (S100A2, NOX1, IGHV7-81, AMH, AGTR1). Furthermore, the predictive nomogram was established and verified.Results: As a result, we successfully constructed and validated an immune-related prediction model for PCa. In this model, 5-genes model showing more stable than other gene groups. Consistent with our expectations, the signature can independently predict the survival outcome of PCa patients. Patients with high-immune risk were found correlated with advanced stage. We also found that high S100A2 gene expression has a lower biochemical recurrence, high AMH gene expression has a higher gleason score, lymph node metastasis rate and tumor grade, a lower lymphnodes positive, high ATGR1 gene expression has a lower psa value.Conclusion: our study showed that our 5-gene immune-related signature could treated as an independent prognostic indicator for PCa.
Minority Resampling Based Ensemble Framework Using Enhanced Early Drift Detection Method For Imbalanced Data Streams
Authors: S Priya , Uthra Annie 
Published: January 2021

Abstract
As the data mining applications are increasing popularly, large volumes of data streams are generated over the period of time. The main problem in data streams is that it exhibits a high degree of class imbalance and distribution of data changes over time. In this paper, Timely Drift Detection and Minority Resampling Technique (TDDMRT) based on K-nearest neighbor and Jaccard similarity is proposed to handle the class imbalance by finding the current ratio of class labels. The Enhanced Early Drift Detection Method (EEDDM) is proposed for detecting the concept drift and the Minority Resampling Method (KNN-JS) determines whether the current data stream should be regarded as imbalance and it resamples the minority instances in the drifting data stream. The K-Nearest Neighbors technique is used to resample the minority classes and the Jaccard similarity measure is established over the resampled data to generate the synthetic data similar to the original data and it is handled by ensemble classifiers. The proposed ensemble based classification model outperforms the existing over sampling and under sampling techniques with accuracy of 98.52%.
Effects of Psychological Capital, Coping Style and Emotional Intelligence on Self-Rated Health Status of College Students in China During COVID-19 Pandemic
Authors: Jing Xiangzhi , Meng Hongling , Li Yuping , Lu Lingeng , yao yongcheng 
Published: January 2021

Abstract
Objective To explore the relationship between the self-reported health status, emotional coping style, emotional intelligence and positive psychological state of college students during the COVID-19 pandemic. Methods The questionnaires of Self-rated Health Measurement Scale (SRHMS), Emotional Intelligence Scale (EIS), Psychological Capital Questionnaire (PCQ), Simplified Coping Style Questionnaire (SCSQ)were used for online survey. The study included 367 undergraduates. Results Male undergraduates had significantly higher psychological capital scores than female (P < 0.05), and those without siblings had significantly higher emotional intelligence and psychological capital scores than those with (P < 0.05). The students from urban had significantly higher emotional intelligence scores than those from rural (P < 0.05). Students who spent less than 3 hours online per day had significantly higher self-rated health scores than those spending 6 hours online per day (P < 0.05), and those who spent 3–6 hours online per day was significantly higher psychological capital scores than those who spent more than 6 hours online per day (P < 0.05). The interaction between emotional intelligence, psychological capital and coping styles was statistically significant (β=-0.045,P < 0.05) in health status with coping style ranking the top (β = 21.277). Conclusion: Sex, having siblings or not, birth place and online time per day affected health status, emotional intelligence, and psychological capital in undergraduate students. Coping style is a main positive factor that affects health, which was modified by emotional intelligence and psychological capital. In this pandemic emergency, positive coping style with optimistic emotional perception and understanding is an important measure against the pandemic-induced health problem.
Epithelial Remodelling After Epithelium-off Continuous Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus
Authors: Piao Junjie , Li Ying , Wang Meng , Kim Sun Joo , Joo Choun-Ki , Yoon Geunyoung 
Published: January 2021

Abstract
Background: To analyse regional corneal epithelial and stromal remodelling after epithelium-off (epi-off) continuous accelerated corneal collagen cross-linking (CXL) for keratoconus (KC).Methods: In this retrospective study, 20 patients (33 eyes) who were treated with epi-off continuous accelerated CXL (KXL system; Avedro, Inc., Waltham, MA, USA). All treatments were performed with ultraviolet-A (UVA) (energy, 7.2 J/cm2; irradiance, 30 mW/cm2), using continuous (4 min) illumination. The postoperative changes in corneal biometric and visual outcomes were compared. The corneal thickness changes were evaluated using anterior segment optical coherence tomography (Optovue). All patients were followed up for 12 months postoperatively.Results: Uncorrected distance visual acuity significantly improved from 1.06 ± 0.49 logarithm of the minimum angle resolution (logMAR) to 0.71 ± 0.37 logMAR at 3 months after epi-off continuous accelerated CXL (p<0.001). The corneal epithelial thickness changes were significant in the inner nasal at -1.48 ± 3.65 µm (p=0.024), -1.76 ± 4.21 µm in the inner superior-nasal (p=0.024), -1.52 ± 4.02 µm in the inner superior (p=0.046), -1.97 ± 4.57 µm in the inner superior-temporal (p=0.018), -2.12 ± 4.46 µm in the outer inferior (p=0.014), -2.15 ± 4.82 µm in the outer inferior-nasal (p=0.022), -1.73 ± 4.45 µm in the outer temporal (p=0.019) at 6 months after epi-off continuous accelerated CXL.Conclusions: Significant regional epithelial remodelling occurs after epi-off continuous accelerated CXL; a more regular corneal thickness profile and keratometric variations were observed after treatment.
Influences of Consumption of Herbal Tea Containing Galactagogue on Composition of Human Milk Macronutrients
Authors: Kundakçı Simay , Aktaç Şule , Boran Perran 
Published: January 2021

Abstract
BackgroundThe aim of this study was to determine the influences of herbal tea consumption containing galactagogues on the composition of human milk energy and macro nutrients. MethodsIt was a cross-sectional study conducted between March and May 2018, involving mothers having 0-4 month old infants consuming (n=43) and non-consuming (n=56) herbal tea containing galactagogue. Energy and macronutrients of human milks collected from mothers by hand expression were measured using a human milk analyzer, and retrospective 1-day food consumption records were obtained. Significance level was accepted as p <0.05. ResultsMost preferred herbal tea type consumed by mothers was fennel (58.1%); followed by herbal tea mixture (34.9%) and cumin fennel (4.7%) respectively. It was determined that the consumption of herbal tea containing galactagogues did not affect the energy and macro nutrient content of the human milk (p>0.05). No statistically significant difference was found between the type of herbal tea containing galactagogue and the content of human milk (p>0.05). ConclusionIt was determined that the herbal tea containing galactagogue did not affect the content of breast milk energy and macronutrients. Also; it was proposed that the safety, efficacy and possible side effects of these teas should be assessed in larger sample groups and randomized controlled trials.
Preoperative Ultrasound to Map the Three-Dimensional Anatomical Distribution of the Lateral Femoral Cutaneous Nerve in Direct Anterior Approach for Total Hip Arthroplasty
Authors: Zhang Yu , Yao Yao , Wang Yexian , Zhuang Zaikai , Shen Ying , Jiang Qing , Chen Dongyang 
Published: January 2021

Abstract
Background：The postoperative complaints of hypoaesthesia or a burning sensation due to lateral femoral cutaneous nerve (LFCN) injury in patients is not yet solved. The present study aimed to identify the three-dimensional (3D) distribution of LFCN using preoperative ultrasound and evaluate the rate of injury in direct anterior approach for total hip arthroplasty. Methods： A total of 59 patients were allocated to the ultrasound group and 58 patients were in the control group. Surgeons received the data of 3D distribution of LFCN only in the ultrasound group before surgery with respect to the direction, the depth on the skin, and the length to tensor fasciae latae (TFL). The anatomical characteristics of LFCN in the surgical region were summarized. At 1 and 3 months post-surgery, the rate of LFCN injury and abnormal sensitive area were evaluated in both groups. Results： Based on the data from the ultrasound group, over 90% of patients had one or two branches of LFCN. LFCN always courses in the fascia layer, the depth ranged from 6.8±2.6 (3.0 ~12.0) mm to 11.1±3.4 (4.0 ~17.0) mm and depended on the thickness of the subcutaneous fat, and length was 3.3±4.6 (-5.0 ~10.0) mm at proximal part and -2.7±4.7 (-10.0 ~8.0) at distal end to the medial edge of TFL. Both the rate of LFCN injury and abnormal sensory area in the ultrasound group were significantly lower than those in the control group (3.4% VS 25.9%, P=0.001, χ21=11.893, at 1 month; 3.4% VS 22.4%, P=0.005, χ21=9.471, at 3 months).Conclusions： LFCN mostly courses along the medial border of TFL in the fascia layer. The 3D distribution of LFCN could help the surgeons to evaluate the risk of injury preoperatively and decrease the rate of injury during the operation. However, some branch injuries, especially for the fan type LFCN, could not be avoided.
Suppression of MD2 Inhibits Breast Cancer in Vitro and in Vivo
Authors: Zheng Shurong , Fu Weida , Ma Ruimin , Huang Qidi , Gu Junwei , Zhou Jieyu , Lu Kangkang , Guo Guilong 
Published: January 2021

Abstract
Background: To explore the effects of the intervening measure targeting myeloid differentiation 2 (MD2) on breast cancer progression in vitro and in vivo. Methods: The expression of MD2 in normal breast cells (Hs 578Bst) and three kinds of breast carcinoma cell lines (MCF-7, MDA-MB-231s and 4T1) were detected by western blot. MTT assay was used to detect the proliferation of 4T1 cells treated by L6H21, cell migration and invasion was measured by wound healing assay and transwell matrigel invasion assay, respectively. In addition, to further study the role of MD2 in tumor progression, we assessed the effects of inhibition of MD2 on the progression of xenograft tumors in vivo.Results: The expression of MD2 is much higher in MDA-MB-231s and 4T1cells than that in normal breast cells (Hs 578Bst) or MCF-7 cells (P <0.05). In vitro, suppression of MD2 by L6H21 has a significant inhibition of proliferation, migration and invasion in 4T1 cells in dose-dependent manner. In vivo, L6H21 pretreatment significanly improved survival of 4T1-bearing mice (P <0.05). Additionally, we also observed that there was none of the mice died from the toxic of 10 mg·kg−1 L6H21 in 60 days. Conclusion: Overall, this work indicates that suppression of MD2 shows progression inhibition in vitro and significantly prolong survival in vivo. These findings provide the potential experimental evidence for using MD2 as a therapeutic target of breast carcinoma.
Allogeneic Neural Stem Cell Transplant Promotes Functional Recovery of Locomotion After Complete Transected Spinal Cord Injury Predominantly by Secreting Neurotrophic Factors
Authors: Liu Shuo , Fan Caixia , Xie Yuanyuan , Wang Liudi , Cui Yanyan , Wang Bin 
Published: January 2021

Abstract
ObjectiveCell-based therapy is a promising strategy for spinal cord injury (SCI) repair, but faced the challenges to direct the neuronal differentiation of appropriate neuron subtypes for achieving the neuronal replacement. We investigated whether allogeneic beforehand in vitro differentiated neural stem cells (NSCs) could relieve the adverse effects of regeneration inhibitory niche and promote motor functional recovery by accomplishing neuronal replacement after transplant into SCI rats. MethodsCollagen scaffold combined with digested NSCs, NSC sphere, differentiated neurons, and sphere of differentiated neurons were transplanted into completely transected SCI in rats and therapeutic outcomes were investigated. Next, we enriched complex of neurotrophic factors secreted from culture medium of NSCs, neurons, and sphere of neurons and a total of 2 mg total enriched protein combined with collagen scaffold were transplanted into SCI to further assay whether allogeneic NSCs transplant promotes the recovery of SCI predominantly by secreting neurotrophic factors. ResultsNSCs differentiated into neurons in density-dependent manner in vitro and sphere of NSCs could counteract myelin-induced inhibition of neuronal differentiation. Collagen scaffold combined with digested NSCs, NSC sphere, differentiated neurons, and sphere of differentiated neurons were transplanted into completely transected SCI in rats. Overall the cell treatment groups had a much better locomotor recovery, tissue remodeling, and newborn neuron formation than alone collagen scaffold treatment, compared with alone collagen material transplant and control group. However, unexpectedly, the differentiated cell treatment (differentiated neurons and sphere of differentiated neurons transplants) did not present striking better locomotor recovery than the undifferentiated NSCs and sphere of NSCs treatments, only sphere of neurons showed a slight increase in BBB score compared to other cell treatments. Next, we enriched complex of neurotrophic factors secreted from culture medium of NSCs, neurons, and sphere of neurons. BBB score analysis showed that the secreted neurotrophic factors from NSCs, neurons, and sphere of neurons would promote functional recovery of SCI to the same extent. ConclusionAllogeneic NSCs transplant promotes functional recovery of SCI predominantly by secreting neurotrophic factors, not direct neuronal replacement of differentiated neurons from transplanted cells.
Iranian Nurses’ Perspective of Barriers to Sexual Counseling For Patients With Myocardial Infarction
Authors: Shahrbabaki Parvin Mangolian , Rabori Roghayeh Mehdipour , Gazestani Tayyebeh , Forouzi Mansooreh Azzizadeh 
Published: January 2021

Abstract
Background: Sexual counseling is an important component of cardiac rehabilitation that. This study aimed to investigate Iranian nurses’ perspective of barriers to sexual counseling for patients with myocardial infarction. Methods: This cross-sectional study was performed on 169 nurses. Instruments included demographic characteristics and barriers to providing sexual counseling. Results: The strongest barrier was related to patients’ religion, and belief (2.83 ± 0.52) and embarrassment (2.82 ± 0.52%), the nurses are not comfortable discussing sexual issues (2.67 ± 0.62), lack of experience in the field of sexual counseling (2.62 ± 0.65), and sexual hesitation in advising patients (2.57 ± 0.7). About organizational barriers, the highest mean scores were related to the lack of support from managers (2.67 ± 0.66) and the lack of a proper supervision system (2.62 ± 0.72). Conclusion: patient-related barriers were the most common barriers rooted in the culture dominant in society regarding sex issues. Therefore, it should be cultured through continuing education and the mass media so as not to be perceived as a taboo in health care settings. Health professionals should be change the attitudes of patients towards sexuality through sexual health education and counseling to meet patients' needs and improve their sexual health.