bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Insulin Use Worsen the Prognosis of COVID-19 Patients with Type 2
Diabetes Mellitus? A Current Update
Authors: Wiyarta Elvan , Wisnu Wismandari 
Published: November 2021

Background:
Background: Insulin has recently received special attention concerning its use in
COVID-19 patients. Although controversial, insulin can be able to worsen the prognosis of
COVID-19 patients with Type 2 Diabetes Mellitus (T2DM) through an inflammatory pathway.
This uncertain aspect brings a new perspective related to insulin use in this pandemic era. Objective:
We tried to collect and analyze various studies related to this issue to provide a complete picture
of the prognosis of insulin use in COVID-19 patients with T2DM.

Methods:
We comprehensively searched PubMed, Cochrane CENTRAL, Embase, EBSCO CINAHL,
MEDLINE, and grey literature databases for studies investigating the effect of insulin on
COVID-19 outcomes, including mortality, hospitalization, disease progression, other prognostic
surrogates. Records were screened against the eligibility criteria.

Result:
2556 articles were retrieved and were screened. A total of 8 studies were included in the final
analysis. There are no studies with solid evidence supporting the effect of insulin treatment on
the worsening of the prognosis of COVID-19 patients with T2DM. Although several studies have
shown that insulin is associated with a poor prognosis, most studies have not considered confounders.
This certainly makes it challenging to analyze the effects of insulin independently.

Conclusion:
We propose that COVID-19 patients with T2DM continue to receive insulin, but with
careful observation of the risk of disease progression.
Nanotechnology Applications in Plant Tissue Culture and Molecular
Genetics: A Holistic Approach
Authors: Al-Qudah Tamara , Mahmood Sami H. , Abu-Zurayk Rund , Shibli Rida , Khalaf Aya , Lambat Trimurti L. , Chaudhary Ratiram G. 
Published: November 2021

:
Nanotechnology is one of the most important modern sciences that has integrated all sectors
of science. Nanotechnology has been applied in the agricultural sector in the last ten years in
pursuit of increasing agricultural production and ensuring food security. Plant biotechnology is an
essential science that is concerned with plant production. The use of nanotechnology in plant biotechnology
under controlled conditions has facilitated the understanding of important internal mechanisms
of the plant biological system. The application of nanoparticles (NPs) in plant biotechnology
has demonstrated an interesting impact on in vitro plant growth and development. This includes the
positive effect of the NPs on micropropagation, callus induction, somatic embryogenesis, cell suspension
culture, and plant disinfection. In addition, other biotechnology processes, including the
genetic transformation of plants, plant conservation, and secondary metabolite production have improved
by the use of NPs. Furthermore, nanotechnology is used to improve plant tolerance to different
stress conditions that limit plant production. In this review article, we attempt to consolidate the
achievements of nanotechnology and plant biotechnology and discuss advances in the applications of
nanotechnology in plant biotechnology. It has been concluded that more research is needed to understand
the mechanism of nanoparticle delivery and translocation in plants in order to avoid any future
hazardous effects of nanomaterials. This will be key to the achievement of magnificent progress in
plant nanobiotechnology.
Active Capsule Endoscope Robot: Current Status and Future Perspectives
Authors: Jiang Jingang , Yu Xiaoyang , Sun Yang , Song Shichang , Wu Dianhao 
Published: November 2021

Background:
China is a big country with a vast territory, in which gastropathy has become
a common high-incidence disease in daily life. Gastroscopy is an important means of diagnosis
of gastropathy, but the use of a gastroscope causes a lot of pain to patients. A cable-free,
non-invasive and painless diagnosis and treatment tool, an active capsule endoscope robot, can
solve this problem very well. Capsule robot has become a new development hotspot.

Objective:
The study aims to provide an overview of the active endoscope capsule robot and introduce
its classification, characteristics and development.

Method:
This paper summarizes various scientific research achievements of the active endoscope
capsule robot. The structural characteristics, advantages and disadvantages of various active endoscope
capsule robots are introduced.

Results:
The active endoscope capsule robot has been analyzed and compared to other models. Its
typical characteristics have been summarized. The main problems in its development are analyzed,
its development trend is prospected, and the research status and future of active endoscope
capsule robot are discussed.

Conclusion:
The active capsule robot is classified into two categories: bionic and non-bionic. The
analysis shows that the capsule robot is an effective and safe initiative and has a very broad application
prospect for various gastrointestinal tests compared to gastroscope, and helps alleviate the
pain of patients.
Dukungan Sosial Teman Sebaya Sebagai Prediktor Psychological Well-Being pada Remaja
Authors: Mufidha Ashifa 
Published: November 2021

Penelitian ini bertujuan untuk mengetahui pengaruh dukungan sosial dari teman sebaya terhadap psychological well-being pada remaja. Pendekatan penelitian ini menggunakan pendekatan kuantitatif desain korelasional. Penelitian dilakukan di SMP IT Masjid Syuhada. Sampel diambil menggunakan teknik acak sederhan dan mendapatkan 163 siswa. Pengumpulan data dilakukan dengan menyebarkan 2 kuesioner, yaitu Skala Psychological Well-Being dan Skala Dukungan Sosial Teman Sebaya. Teknik analisis yang digunakan adalah analisis deskriptif dan analisis regresi linear. Hasil penelitian menunjukkan bahwa terdapat pengaruh positif dukungan sosial teman sebaya terhadap psychological well-being pada remaja dengan R = 0,651, R2 0,424, p < 0,001. Variabel dukungan sosial teman sebaya berkontribusi sebanyak 42,4% terhadap psychological well-being pada remaja. Sumbangan tertinggi adalah dimensi hubungan yang positif dengan orang lain, yaitu sebesar 35,77% dan sumbangan terendah adalah dimensi tujuan hidup sebesar 9,27%.
Strategi Coping Pada Mahasiswa Yang Sudah Menikah
Authors: Zulfikar Hamzah , Nurhayati Siti Rohmah 
Published: November 2021

Penelitian ini bertujuan untuk mengkaji dan mendeskripsikan permasalahan yang terjadi pada mahasiswa yang sudah menikah dan strategi coping yang dilakukannya. Penelitian ini menggunakan pendekatan kualitatif dan menggunakan teknik purposive sampling. Kriteria subjek adalah mahasiswa yang sudah menikah dengan minimal usia pernikahan satu semester (6 bulan). Pengumpulan data penelitian dilakukan dengan cara interview. Instrumen dalam penelitian ini yaitu peneliti sendiri dengan dibantu pedoman wawancara dan alat perekam suara. Uji keabsahan data dilakukan dengan member checking dan triangulasi data. Teknik analisis data menggunakan pendekatan kualitatif deskriptif. Hasil penelitian menunjukkan bahwa permasalahan-permasalahan yang muncul pada mahasiswa yang sudah menikah adalah masalah kekhawatiran, keturunan, dan masalah ekonomi. Dari masalah-masalah tersebut, strategi coping yang digunakan adalah problem-focused coping, emotional-focused Coping, dan Strategi religious-focused coping.
The Use of Smart Speakers in Care Home Residents: Implementation Study
Authors: Edwards Katie J , Jones Ray B , Shenton Deborah , Page Toni , Maramba Inocencio , Warren Alison , Fraser Fiona , Križaj Tanja , Coombe Tristan , Cowls Hazel , Chatterjee Arunangsu 
Published: November 2021

Background
The use of smart speakers to improve well-being had been trialed in social care by others; however, we were not aware of their implementation in most care homes across a region in the Southwest of the United Kingdom. For the widespread adoption of new technology, it must be locally demonstrable and become normalized.

Objective
The aim of this study was to install smart speakers in care homes in a rural and coastal region and to explore if and how the devices were being used, the barriers to their implementation, and their potential benefits.

Methods
Email, workshops, drop-in sessions, phone, and cold calling was used to contact all 230 care homes, offering a free smart speaker and some advisory support. Care homes accepting the devices were asked to complete a feedback diary. Nonresponse rate for diary completion was high and was thus supplemented with a telephone survey.

Results
Over the course of 7 months, we installed 156 devices in 92 care homes for older people, 50 devices for people with physical or mental health needs, and 8 for others. The devices were used mainly for music but also for poetry, recipes, light controls, jokes, and video calls. Care home managers reported the benefits for the residents, including enhanced engagement with home activities, enjoyment, calming effects, and the acquisition of new skills. Implementation problems included internet connectivity, staff capacity, and skills.

Conclusions
Affordable consumer devices such as smart speakers should be installed in all care homes to benefit residents. Voice-activated technologies are easy to use and promote interaction. This study indicates that implementation in care homes was possible and that smart speakers had multifaceted benefits for residents and staff. Most care homes in this region now use smart speakers for their residents, thereby normalizing this practice.
Cross-Cultural Modification Strategies for Instruments Measuring Health Beliefs About Cancer Screening: Systematic Review
Authors: Lei Fang , Lee Eunice 
Published: November 2021

Background
Modification is an important process by which to adapt an instrument to be used for another culture. However, it is not fully understood how best to modify an instrument to be used appropriately in another culture.

Objective
This study aims to synthesize the modification strategies used in the cross-cultural adaptation process for instruments measuring health beliefs about cancer screening.

Methods
A systematic review design was used for conducting this study. Keywords including constructs about instrument modification, health belief, and cancer screening were searched in the PubMed, Google Scholar, CINAHL, and PsycINFO databases. Bowling’s checklist was used to evaluate methodological rigor of the included articles. Results were reported using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) approach with a narrative method.

Results
A total of 1312 articles were initially identified in the databases. After removing duplications and assessing titles, abstracts, and texts of the articles, 18 studies met the inclusion criteria for the study. Based on Flaherty’s cultural equivalence model, strategies used in the modification process included rephrasing items and response options to achieve semantic equivalence; changing subjects of items, changing wording of items, adding items, and deleting items to achieve content equivalence; adding subscales and items and deleting subscales and items to achieve criterion equivalence. Solutions used to resolve disagreements in the modification process included consultation with experts or literature search, following the majority, and consultation with the author who developed the scales.

Conclusions
This study provides guidance for researchers who want to modify an instrument to be used in another culture. It can potentially give cross-cultural researchers insight into modification strategies and a better understanding of the modification process in cross-cultural instrument adaptation. More research could be done to help researchers better modify cross-cultural instruments to achieve cultural equivalence.
Ataluren delays loss of ambulation and respiratory decline in nonsense mutation Duchenne muscular dystrophy patients
Authors: McDonald Craig M , Muntoni Francesco , Penematsa Vinay , Jiang Joel , Kristensen Allan , Bibbiani Francesco , Goodwin Elizabeth , Gordish-Dressman Heather , Morgenroth Lauren , Werner Christian , Li James , Able Richard , Trifillis Panayiota , Tulinius Már , Ryan M , Jones K , Goemans N , Campbell C , Mah JK , Selby K , Chabrol B , Pereon Y , Voit T , Gidaro T , Schara U , Kirschner JB , Nevo Y , Comi GP , Bertini E , Mercuri E , Colomer J , Nascimento A , Vilchez JJ , Tulinius M , Sejersen T , Muntoni F , Bushby K , Guglieri M 
Published: November 2021

Aim:
We investigated the effect of ataluren plus standard of care (SoC) on age at loss of ambulation (LoA) and respiratory decline in patients with nonsense mutation Duchenne muscular dystrophy (nmDMD) versus patients with DMD on SoC alone.
Patients & methods:
Study 019 was a long-term Phase III study of ataluren safety in nmDMD patients with a history of ataluren exposure. Propensity score matching identified Study 019 and CINRG DNHS patients similar in disease progression predictors.
Results & conclusion:
Ataluren plus SoC was associated with a 2.2-year delay in age at LoA (p = 0.0006), and a 3.0-year delay in decline of predicted forced vital capacity to <60% in nonambulatory patients (p = 0.0004), versus SoC. Ataluren plus SoC delays disease progression and benefits ambulatory and nonambulatory patients with nmDMD.
ClinicalTrials.gov registration
:
NCT01557400
.
Kenaikan Tarif Air Minum Dalam Standar Contract: Tinjauan Perlindungan Konsumen
Authors: Utami Devi Yustisia , Yustiawan Dewa Gede Pradnya 
Published: November 2021

Negara memiliki kewenangan untuk mengelola sumber daya air di daerah Kabupaten/Kota melalui perusahaan air minum daerah. Untuk memperoleh pelayanan air minum maka masyarakat harus berlangganan air kepada perusahaan air minum. Perusahaan air minum sewaktu-waktu dapat menaikkan tarif air secara sepihak yang terkesan menimbulkan kerugian bagi pelanggan. Hal ini menarik untuk dikaji dari aspek perlindungan konsumen. Tujuan dari penelitian ini adalah untuk mengetahui hubungan hukum yang terjadi antara perusahaan air minum dengan konsumennya dan untuk mengetahui pengaturan yuridis yang memuat aspek perlindungan konsumen atas kenaikan tarif air minum. Jenis penelitian dalam tulisan ini adalah penelitian yuridis normatif yang mengkaji norma hukum dengan pendekatan perundang- undangan dan konseptual. Hasil penelitian yang diperoleh, bahwa hubungan hukum yang terjadi antara pelanggan dengan perusahaan air minum adalah hubungan contractual, dan pengaturan yuridis aspek perlindungan konsumen atas kenaikan tarif air minum diatur dalam UU Perlindungan Konsumen No. 8-1999 serta Permendagri mengenai Perhitungan dan Penetapan Air Minum No. 71-2016.
Faktor-Faktor Ambisi Politik Imigran Korea Utara di Korea Selatan (Studi Kasus: Keterlibatan Thae Yong-Ho dan Ji Seong-Ho sebagai Kandidat dalam Kontestasi Pemilu Legislatif di Korea Selatan Tahun 2020)
Authors: Naomi Ega Eugenia , Muhyidin Ali 
Published: November 2021

Artikel ini membahas tentang bagaimana imigran asal Korea Utara terlibat dalam kontestasi di Pemilihan Legislatif tahun 2020 di Korea Selatan. Dengan menggunakan metode penelitian kualitatif dan teknik studi literatur, penelitian ini menjelaskan faktor-faktor apa saja yang mendorong ambisi politik Thae Yong-ho dan Ji Seong-ho. Temuan penelitian ini menunjukkan bahwa ambisi politik kedua tokoh tersebut muncul didorong oleh berbagai faktor personal yaitu sosialisasi politik, pengalaman profesional individu, rekrutment politik, serta isu dan sikap politik terhadap kebijakan luar negeri Presiden Moon Jae-in mengenai hubungan Korea Selatan dan Korea Utara. Identifikasi faktor pendorong ambisi politik individu tidak hanya penting untuk menjawab pertanyaan mengapa individu berkompetisi pemilu, namun juga bagaimana ambisi personal berkembang sejalan dengan strukur kesempatan politik. Hasil penelitian ini diharapkan dapat menambah perspektif terkait kebijakan politik di negara demokrasi dalam merespon isu imigran.
Sistem Informasi Geografis Peternakan Ayam Pada Kabupaten Jembrana Berbasis Website
Authors: Fatmasari Ni Made Mila , Swastika I Putu Agus , Utami Nengah Widya 
Published: November 2021

This thesis proposal discusses the difficulties of chicken buyers to get information on chicken farms in Jembrana Bali, and the limited information obtained, currently complete information on farm layout in Jembrana Regency, only exists at the Jembrana District Animal Husbandry Service, then chicken breeders are also it is still difficult to provide information about their layout due to the limited means of adequate information in each village. So a chicken farm geographic information system was created with the aim of helping chicken buyers, livestock raisers and the Chicken Farming Service to get information on chicken breeding in Jembrana Regency more easily.Keywords— livestock, chicken, GIS, Website, Jembrana
PENGEMBANGAN VIDEO PEMBELAJARAN ANIMASI 2 DIMENSI MATA PELAJARAN AGAMA HINDU MENGENAI SAD RIPU STUDI KASUS KELAS VI (ENAM) SD NEGERI 1 KALIBUKBUK
Authors: Ekaputra Putu Wisnu , Sindu I Gede Partha , Suyasa P Wayan Arta 
Published: November 2021

The purpose of this study is to determine (1) the design and impementation of the development of a 2-dimentional animation learning video for sad ripu of hindu religion subject for 6th grade at SD Negeri 1 Kalibukbuk. The result of 6th grade response shows that 2-dimentional animation learning video is suitable for learning media of sad ripu of hindu religion subject. Research method used for the development is MDLC (Multimedia Development Life Cycle) approach which contained several steps, they are concept, design, material collecting, assembly, testing, and distribution. Study result shows that the elementary student as user of the learning video gave positive response and very enthusiastic about learning sad ripu of hindu religion subject with learning video. (2) From the result of response test to 10 elementary student as respondent to see the feasibility of learning video obtained result of 85%, which means 2-dimentional animation learning video for sad ripu of hindu religion subject is included in the good category. Keywords: Learning Video, 2D Animation, Hinduism, Sad Ripu, MDLC (Multimedia Development Life Cycle).
Konstruksi Kepemimpinanan Atas Tradisi Giri Kedaton Sebagai Identitas Sosial Budaya Masyarakat Kabupaten Gresik
Authors: Mustakim Mustakim , Ishomuddin Ishomuddin , Winarjo Wahyudi , Khozin Khozin 
Published: November 2021

Penelitian ini bertujuan untuk mendeskrisikan konstruksi sosial pemimpin atas tradisi Giri Kedaton sebagai identitas sosial budaya masyarakat Kabupaten Gresik. Penelitian ini dilaksanakan di Kabupaten Gresik Jawa Timur dengan menggunakan paradigma interpretatif dan pendekatan kualitatif. Data diperoleh dari sumber primer dan sekunder. Teknik pengumpulan data dilakukan melalui observasi nonpartisipan, wawancara, dan dokumentasi, dan teknik purposive sampling. Analisis data dilakukan melalui open coding, axial coding, dan selective coding, sedangkan analisis data melalui persistent observation, triangulation, member check and peer reviewing, dan referencial adequacy check. Hasil penelitian ini menunjukkan bahwa: identitas sosial sebagai realitas adalah ciptaan manusia kreatif melalui kekuatan konstuksi sosial di sekitarnya yang dikuatkan oleh hadirnya leader melalui regulasi pendukungnya. Proses penguatan identitas yang dilakukan melalui otoritas leader lebih efektif daripada pembentukan identitas oleh masyarakat. Konstruksi sosial atas realitas cenderung berlangsung melalui leader secara hirarkis-vertikal, bersifat spasial, yaitu berlangsung dari pimpinan kepada bawahannya. Berpijak dari teori konstruksi sosial atas realitas Peter L. Berger dan Luckman dengan melihat variabel leader menjadi sangat substansi dalam proses eksternalisasi, objektivasi, dan internalisasi, maka dapat dikatakan bahwa sifat dan kelebihan leader sebagai agen dalam proses eksternalisasi, objektivasi, dan internalisasi telah memperbaiki proses konstruksi sosial atau realitas yang berjalan lambat.
KECERDASAN SPASIAL DALAM MEMAHAMI TRIMATRA: STUDI STRATEGI PEMBELAJARAN MATA KULIAH NIRMANA 2 (TRIMATRA)
Authors: Ernawati Ernawati 
Published: November 2021

ABSTRAK Tujuan penelitian ini untuk berdiskusi strategi pembelajaran yang oftimal sehingga tercapai tujuan sesuai dengan visi dan misi mata kuliah Nirmana 2 (Trimatra) yang tercantum pada kurikulum. Metode pada penelitian ini menerapkan metode tindakan kelas (PTK) dengan pendekatan model PTK dari Kurt Lewin. Nirmana 2 (Trimatra) mempersiapkan mahasiswa untuk memiliki kepekaan rasa, ketajaman analisis visual dan pemahaman mendalam terhadap ilmu dasar seni rupa dan desain. Nirmana berpengaruh terhadap mata kuliah lainnya yang berhubungan denagn teori maupun praktik desain komunikasi visual. Modifikasi strategi pembelajaran nirmana 2 (Trimatra) dengan kontekstual (visual-spasial) dan evaluasi penilaian mampu menjadi poin penting dalam mengatur suasana kelas yang kondusif, meningkatkan kualitas semangat belajar dan menigkatkan pemahaman serta kreativitas mahasiswa untuk berkarya.Katakunci : Nirmana 2, Spasial, Strategi Pembelajaran, visualABSTRACT The purpose of this study is to discuss optimal learning strategies so that the objective is achieved under the vision and mission of Nirmana II (Trimatra) courses listed in the curriculum. The method in this study applied classroom action research (PTK) with the research approach from Kurt Lewin, which aimed to explore the strategic roles of the spatial intelligence learning toward the process of students’ creativity development in Nirmala learning. Arts and design students have a close relationship with creativity and sensitivity in which they need preparation in understanding the governance of design elements. Spatial intelligence is an ability to visualize the ideas relating to space and place. Spatial intelligence is an intelligence possessed by most fine art and design students. Nirmana II (Trimatra) prepares students to have a sense of taste, sharpness of visual analysis, and a deep understanding of the basic fine arts and design. Nirmana influences other courses relating to the theory and practice of visual communication design. Modification of the Nirmana II learning strategy (Trimatra) with contextual (visual-spatial) and evaluation assessment can be important points in managing a conducive classroom atmosphere, improving the quality of enthusiasm for learning, and increasing students' understanding and creativity to work. The analysis process is done by collecting data that is measurable.Keywords: Nirmana II, spatial, learning strategies, visual