bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological Impacts Among Yemeni Healthcare Workers During the COVID-19 Pandemic: an Electronic-based, Cross-sectional Analytical Survey
Authors: Alrubaiee Gamil Ghaleb , Al-Qadasi Farouk Abdulrahman , Al-Qalah Talal Ali Hussein , Cole Jennifer Ann , Alburiahy Yaser abdullah Ghaleb , Alsabri Mohammed 
Published: September 2021

Abstract
Background: Yemeni HCWs face higher levels of psychological stress than others in the fight against the COVID-19 pandemic due to the country's war and internal conflict. The current study investigates the levels of stress, anxiety, insomnia, depression, and well-being among Yemeni HCWs during the COVID-19 pandemic. Methods: A web-based, cross-sectional survey was used among 1,248 Yemeni HCWs. An electronic self-reported questionnaire was used to collect data. The URL link was distributed to the HCWs via social media and emails. The Statistical Package for Social Sciences (IBM SPSS), version 24.0 was used in managing and analyzing the data collected. T-test and one-way ANOVA were used to compare the participants’ data and independent variables. Spearman’s correlation coefficients were used to determine the relationship between study variables. A p-value of < 0.05 with a 95% confidence interval was considered statistically significant. The survey was conducted between 6 November 2020, 11 PM to 3 April 2021, 11 PM.Results: The results indicated that 73.0, 57.3, 49.8, 53.2, and 85.2% of all HCWs reported symptoms of moderate or severe stress, insomnia, anxiety, depression, and worse quality of life, respectively. Out of ten independent variables, five were statistically significant (years of experience, working hours per day, marital status, age, and working days per week) (p < 0.05). The results further showed significant positive correlations between stress and scores of anxiety, insomnia, and depression and also between anxiety and insomnia and depression and between insomnia and depression. There was significant negative correlation between wellbeing scores and scores of stress, anxiety, insomnia, and depression.Conclusion: Yemeni HCWs experience considerable levels of stress, anxiety, depression, insomnia, and poor quality of life. Psychological support to build resilience to the prevailing conditions may need to be embedded into medical school training and continuing professional development to help retain HCWs within Yemen, as amongst the respondents where was a high percentage of HCWs under 40 years of age (85.8%) and with less than 10 years’ experience (72.7%), a consequence of many more experienced medics leaving Yemen for safer and more secure jobs elsewhere.
Novel PHEX Variants and Splicing Mutations in Patients with X-Linked Hypophosphatemia
Authors: Xing Xuesha , Gao Jinlan , Ma Hongwei , Zhang Lina , Li Fang , Yang Leilei , Luo Yang 
Published: September 2021

Abstract
Background: X-linked hypophosphatemia rickets (XLH) is a genetic disorder of phosphate wasting that causes the majority of inherited hypophosphatemic rickets. The disease is caused by mutations in the phosphate-regulating endopeptidase gene (PHEX). All types of mutations have been detected in the PHEX gene. There is no clear preference for the position and the type of mutation.Methods: In this study, we performed DNA sequencing and ex vivo splicing analysis to study the PHEX gene in ten sporadic patients and six core families with XLH. Results: A total of 25 patients were studied. Fifteen different mutations were detected in these patients, including five missense mutations, five splicing mutations, two nonsense mutations, two small deletions, and one small insertion. Five mutations were not previously reported. We also characterized the splicing mutations identified in our study, which consisted of exon skipping and activation of new splice sites in an exon or intron. Most of the observed changes resulted in a frameshift of the PHEX open reading frame.Conclusions: The genetic etiology in patients with XLH were successfully identified. This study expands the mutation database of the PHEX gene. We also explored the pathogenesis of XLH caused by splice site mutations. These results will contribute to the diagnosis of XLH and the pathogenicity analysis of mutations in patients.
Screening and Role of circRNAs in Vulvar Lichen Sclerosus
Authors: yang min , Sun Kailu , Chang Jianmin 
Published: September 2021

Abstract
Objective：The aim of this study was to investigate the expression profile of circRNA in Vulvar Lichen Sclerosus, and to identify the underlying core genes of Vulvar Lichen Sclerosus.Methods：rRNA removal was used for sequencing, and mRNA, lncRNA and circRNA differentially expressed between 20 groups of VLS tissues and 20 groups of healthy female vulva skin tissues were screened. Bioinformatics analysis was used to analyze its potential function.Results：A total of 1545 differentially expressed mRNAs were assessed in VLS patients, of which 1541 were upregulated and 1004 were down-regulated; A total of 1453 differentially expressed lncRNAs were assessed, of which 812 were up-regulated and 641 were down-regulated. A total of 79 differentially expressed circRNAs were assessed, of which 54 were upregulated and 25 were down-regulated. The differential expression of CircRNA is closely related to biological processes and molecular functions. The differences in circRNA were mainly related to the "human T-cell leukemia virus 1 infection" signaling pathway and the "axon guidance" signaling pathway.Conclusion：This study identified the profile of abnormal regulation of circRNA in VLS. Biological informatics analysis showed that the dysregulation of circRNAs could be related to the pathogenesis and pathological process of VLS.
Effect of Restrictive Versus Liberal Fluid Management Strategies on Major Adverse Kidney Events in Critically Ill Adult Patients: A Protocol for a Systematic Review and Meta-Analysis
Authors: Herdzik Melissa , Leong Amanda Y. , Kassir Sandy , Sy Eric , Mailman Jonathan F. 
Published: September 2021

Abstract
BackgroundIntravenous fluid therapy is ubiquitous in intensive care units (ICUs). There is increasing recognition of the value of restrictive fluid management strategies, including improved survival and renal function. However, these strategies have not been universally adopted. The purpose of this protocol is to outline our plan for investigating the current literature on the topic of restrictive versus liberal fluid management strategies in all critically ill adults and their associated outcomes, namely major adverse kidney events (MAKE). Methods We will conduct a systematic review and meta-analysis of randomized controlled trials evaluating fluid management strategies in critically ill adults. A search strategy was created with the help of medical librarians, using Ovid MEDLINE, PubMed, EMBASE, CINAHL, Web of Science, and The Cochrane Library. Four independent researchers will perform study selection and data extraction in duplicate. The primary outcome of this study is detection of MAKE by 30 days. Secondary outcomes include reporting MAKE at 60 and 90 days; and mortality, new onset renal replacement therapy, and persistent renal dysfunction at 30, 60, and 90 days. If appropriate, we will perform a meta-analysis using a DerSimonian and Laird random-effects model. Subgroups will include patient type, ICU type, and study quality. Certainty of evidence will be evaluated using the Grading of Recommendations, Assessment, Development and Evaluation approach.DiscussionThe results of this study will synthesize current evidence and better inform the optimal fluid management strategy in critically ill adults.Systematic review registration: Submitted to PROSPERO on June 16th, 2021.
A Systematic Review of Implementation Science Frameworks in Cancer Prevention Interventions: An Exploratory Health Disparities Analysis
Authors: Xiong Serena , Abdi Hamdi I. , Ghebre Rahel , Kulasingam Shalini , Lazovich DeAnn , Mason Susan , Pratt Rebekah J. 
Published: September 2021

Abstract
Background: A growing number of studies have used implementation science (IS) frameworks, such as RE-AIM, to inform and evaluate the implementation of evidence-based cancer prevention services (e.g., cancer screening); however, the impact of such applications is not well understood, including whether the use of an IS framework can lead to reductions in health disparities. The purpose of this systematic review is to explore how IS frameworks can guide adaptations to cancer prevention services to specifically address health disparities. Methods: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered with PROSPERO. Searches were conducted in Ovid MEDLINE, PubMed, PsycINFO, CINAHL, and EMBASE. Search strategies used a combination of terms related to implementation science frameworks, cancer prevention, and/or intervention. All searches were conducted between January to May 2020. The QATSDD tool was used to assess the quality of studies included in the review. Results: A total of 1,025 titles and abstracts were screened, and 84 were deemed eligible for full-text screening. After full-text screening, n=27 articles were included for data abstraction and synthesis. Of the 27 studies that were included, an overwhelming majority (n=19, 70.3%) were based in the United States, utilized mixed-methods (n=12, 44.4%), focused only on a single cancer site (n=21, 81.5%), and took place in a health system (n=18, 66.7%). Approximately half of the studies (n=13, 48.2%) used an IS framework for post-implementation evaluation. Most notably, only one-third of studies (n=9, 33.3%) used an IS framework to address cancer-related health disparities. Of those nine studies, six (66.7%) of them used the Consolidated Framework for Implementation Research (CFIR). Other IS frameworks that were used to inform a health disparities adaptation were Diffusion of Innovations, Knowledge-To-Action, and RE-AIM. Most studies were at moderate risk of bias (n=19, 70.4%).Conclusion: Across the various cancer prevention studies that have been implemented, CFIR has been the dominant IS framework used to address health disparities. The application of such frameworks, however, has been used in pre-implementation and planning studies. It remains to be seen if IS frameworks used within a health disparities context in cancer prevention interventions can reduce cancer-related outcomes.Trial registration: PROSPERO CRD42020171970
Differential Impact of Social Distancing on COVID-19 Spread in the U.S.: By Rurality and Social Vulnerability
Authors: Pilehvari Asal , You Wen , Chen Jiangzhuo , Krulick John , Venkatramanan Srini , Marathe Achla 
Published: September 2021

Abstract
Background. To quantify lessons learned to better prepare for similar pandemic crisis in the future, we assess the overall impact of social distancing on the daily growth rate of COVID-19 infections in the U.S. during the initial phase of the pandemic and the impacts’ heterogeneity by urbanity and social vulnerability of the counties. The initial phase is chosen to purposely identify the essential and largest impact of the first-line of defense measure for similar pandemic: social distancing. Methods. Spatial Durbin models with county fixed effects were used to account for spatial dependencies and identify spatial spillover effects and spatial heterogeneity.Results. Besides the substantial curve flattening effects of social distancing, our results show significant spillover effects induced by neighboring counties’ social distancing levels even in the absence of significant within-county effects. Urban and areas with high social vulnerability are the ones benefit the most from social distancing and high level of compliance is needed. Moderate level is enough in reaching the peak marginal impact in rural and areas with low social vulnerability.JEL classification: I18, H7, C31, C33
The Efficacy and Safety of Longmu Tang Granule for Treating Atopic Dermatitis: Study Protocol for a Single-Centered, Double-Blinded, Randomized Controlled Trial
Authors: LI YAQIN , SHEN TAOTAO , WANG QINGYING , MA MENGXI , TIAN FENGYAN , SHE YUANYAO , TAO YICHENG , WANG JINGJING , CHI HUIYAN , LANG NA , REN JIANXUN 
Published: September 2021

Abstract
Background: Atopic dermatitis (AD) is a chronic relapsing skin disease that has long-term adverse effects on the physical and mental health of children. Current treatments mainly include anti-inflammatory, antibacterial, and anti-allergic interventions, systemic therapy and recently emerging targeted agents. However, these treatments have limited effectiveness and bothersome side effects. The use of traditional Chinese medicine (TCM) is associated with safety and improvements in the clinical symptoms and quality of life of AD patients. However, the poor quality and heterogeneity of studies have not led to sufficient conclusions. Therefore, we will conduct a randomized, controlled, double-blind clinical trial to confirm the efficacy and safety of Longmu Tang granule for the treatment of AD.Methods: This is a single-center, double-blind, randomized, controlled clinical trial. A total of 60 participants will be randomly assigned (1:1) to receive Longmu Tang granule or placebo granule for 8 weeks. The primary outcome is the index of Scoring Atopic Dermatitis (SCORAD). The second outcomes include the children's Dermatology Life Quality Index (CDLQI) and the Number Cancel Test (NCT), and long-term efficacy. Mechanistic outcome is the serum level of inflammatory cytokines, including IgE, tumor necrosis factor (TNF) -α, interleukin-1 (IL-1) and interleukin-6 (IL-6).Discussion: The results of this trial will provide evidence on the efficacy and safety of Longmu Tang granule and prove anti-inflammation of Longmu Tang granule for patients with AD.Trial registration: Chinese Clinical Trial Registry Chictr.org ID: ChiCTR2100041591. Registered on 1 January 2021. https://www.chictr.org.cn/showproj.aspx?proj=62586
Interventions for Expectant and New Parents Designed to Prevent Child Abuse and Neglect in at-risk Families: Protocol for a Systematic Review and Meta-analysis
Authors: Tamon Hiroki , Suto Maiko , Ogawa Kunio , Takehara Kenji , Tachibana Yoshiyuki 
Published: September 2021

Abstract
Background: The prevention of child abuse and neglect is an urgent matter, as abuse and neglect are associated with serious effects even into adulthood, and as there is an increased risk of the offspring of abused children being abused themselves. Intervening as early as possible may prevent abuse that can begin in infancy. Although several systematic reviews and meta-analyses have investigated the effects of interventions on populations at risk for child abuse and neglect, few studies have focused on at-risk women or interventions that start during perinatal periods. This study aims to describe a systematic review to examine the effects of interventions to prevent child abuse and neglect that begin during pregnancy and just after childbirth (less than one year). The study will involve performing a systematic review and meta-analysis based on the latest research articles up to and including November 2020 and a broader literature search.Methods: The protocol was prepared using the 2015 statement of Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. The review will follow Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines/statements. The literature search will be performed using the MEDLINE, PsycINFO, Embase, and Cochrane Central Register of Controlled Trials databases from inception onward. Randomized controlled trials of interventions that begin during pregnancy or the first year postpartum and are designed to prevent child abuse and neglect in at-risk families will be included. Data collection, quality assessment, and statistical syntheses will be conducted by following methods in the protocol that are defined in advance.Discussion: The findings of this systematic review and meta-analysis will be important in clinical and political settings for the prevention of child abuse and neglect. The results of this study will provide a basis for the development of evidence-based intervention programs for expectant and new parents and child abuse prevention policies. Additionally, this study will encourage future studies to conduct more evidence-based intervention programs and illuminate the direction of research on the prevention of child abuse and neglect.Systematic review registration: PROSPERO CRD42021266462
Prevalence and Antimicrobial Resistance of Staphylococcus Species in Operation Room: Systematic Review and Meta-Analysis Protocol.
Authors: Mati Elsai , Mengistu Dechasa Adare , Demmu Yohannes Mulugeta , Barasa Kefelegn Bayu 
Published: September 2021

Abstract
Background
Pathogenic Staphylococcus species in routine medical care settings poses an increased risk of healthcare-associated infections that causes severe infections in humans and increased morbidity and mortality. These species are the most frequently transmitted infectious agents in the operating room that contributed to more than half of surgical site infections. Thus, this study aimed to estimate the global prevalence of staphylococcus species and their antimicrobial resistance profile in operating rooms of health care facilities.
Methods
Nine electronic databases including MEDLINE, Embase, Psych INFO, PubMed, Scopus, Web of Science, google scholar, Science Direct, and CINAHL will be used to collect the articles. To address the articles missed from the above databases, a direct search from google will be made. Similarly, the reference lists of the included articles will be searched manually. The search for the grey literature will be conducted using national or international repositories. Articles written in the English language, and conducted across the world that reported the prevalence of Staphylococcus species in the operating room will be included. Newcastle-Ottawa scale will be used to assess the quality of the included articles. The data will be extracted using Microsoft Excel 2016 and exported to STATA 16.0 software for the analyses. Pooled estimation of the outcome will be performed using DerSimonian-Laird random-effects model. Heterogeneity and publication bias of the studies will be presented with I2 statistics and funnel plots, respectively.
Discussion
Even though several studies laid out sources of microbial contamination as diverse and gram-positive bacteria is a common contaminant in the hospital setting, the prevalence and resistance profile of these contaminants in the operation room is not mentioned. This systematic review will provide evidence on the staphylococcus species in the operation room, the prevalence and antimicrobial resistance of each species. These findings will provide knowledge to clinicians on the level of contamination due to staphylococcus. Only studies published in English will be included and this may limit the current systematic review.
Registration:
Submitted to PROSPERO on 26/7/2021.
Loneliness in Pregnant and Postpartum People and Parents of Children Aged Five Years or Younger: a Scoping Review
Authors: Kent-Marvick Jacqueline , Simonsen Sara E. , Pentecost Ryoko , Taylor Eliza , McFarland Mary M. 
Published: September 2021

Abstract
Background: Despite evidence that loneliness increases during times of transition, and that the incidence of loneliness is highest in young adults, loneliness during pregnancy and new parenthood has not been developed as a program of research. Because loneliness research has primarily focused on older adults and other high-risk populations, the concept of loneliness and its effects on this population are not well understood, leaving a gap in our understanding of the psychosocial needs and health risks of loneliness on pregnant people and new parents. A scoping review has been completed in order to map and synthesize the literature to date on loneliness experienced during pregnancy and the first five years of parenthood.Methods: To address the aim of this review, a wide net was cast in order to detect experiences of perinatal or parental loneliness, and/or instances where loneliness was measured in this population. Among the inclusion criteria were loneliness in people who were pregnant, who were parents in the postpartum period, or who had children aged five years or younger. A search for literature was conducted in December 2020 using nine databases: MEDLINE (Ovid), EMBASE (embase.com), SCOPUS (scopus.com), Cochrane Library including CENTRAL (Wiley), CINAHL (Ebscohost), PsycINFO (Ebscohost), Dissertations & Theses Global (ProQuest) and Sociological Abstracts (ProQuest) and the Web of Science Core Collection (Clarivate).Discussion: Perinatal and parental loneliness studies are limited and have rarely been targeted and developed through a program of research. Loneliness inquiry in this population has frequently been studied in relation to other concepts of interest (e.g., postpartum depression). Alternatively, the importance of loneliness has emerged from study participants as relevant to the research topic during qualitative inquiry. Across studies, the prevalence of loneliness ranged from 32% to 100%. Loneliness was commonly experienced alongside parenting difficulties, with parents feeling as though they were alone in their struggles. As loneliness has been called a sensitive indicator of wellbeing, we believe screening will help healthcare professionals identify common difficulties and early signs of depression experienced during pregnancy and parenthood.The protocol is available on Open Science Framework at DOI 10.17605/OSF.IO/BFVPZ.
Prevalence of Neural Tube Defects (NTDs) In And Around Varanasi Region: Some Observations
Authors: Pandey Vaibhav , Pandey Surendra Kumar , Tiwari Praveen Kumar , Shakya Pragati , Jha Shashank Shekhar , Mishra Ramkrishna , Mishra Pawan kumar , Pandey Govind , Malviya Kapil , Shukla Sheo Prasad , Mohan Devendra , Tiwari Markandeya 
Published: September 2021

Abstract
Congenital anomalies are one of the primary causes of infant mortality and disability in the world. Neural Tube Defects (NTDs) are the most typical type of birth defect resulting from the failure of Neural tube closure. In this retrospective hospital-based study, the data of the children affected byneural tube defects (NTDs) were analyzed. Prevalence of Hydrocephalous, Myelomeningocele (MMC), Encephalocele, Lipo MMC, Meningocele, Spina Bifida Occulta among children with more or less than one year of age and their occurrence in males and females was studied. The frequency of occurrence of cases of neural tube defects was significantly less among all the congenital disabilities, i.e., 5% of total cases studied. The prevalence of myelomeningocele, hydrocephalous, and Encephalocele was higher than other types of NTDs. This study concludes that the prevalence of hydrocephalous and myelomeningocele in this area raises a concern to have more research of their etiology.