bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expectation values of minimum-length Ricci scalar
Authors: Pesci Alessandro 
Published: December 2021

In this paper, we consider a specific model, implementing the existence of a fundamental limit distance [Formula: see text] between (space or time separated) points in spacetime, which in the recent past has exhibited the intriguing feature of having a minimum-length Ricci scalar [Formula: see text] that does not approach the ordinary Ricci scalar [Formula: see text] in the limit of vanishing [Formula: see text]. [Formula: see text] at a point has been found to depend on the direction along which the existence of minimum distance is implemented. Here, we point out that the convergence [Formula: see text] in the [Formula: see text] limit is anyway recovered in a relaxed or generalized sense, which is when we average over directions, this suggesting we might be taking the expectation value of [Formula: see text] promoted to be a quantum variable. It remains as intriguing as before the fact that we cannot identify (meaning this is much more than simply equating in the generalized sense above) [Formula: see text] with [Formula: see text] in the [Formula: see text] limit, namely, when we get ordinary spacetime. Thing is like if, even when [Formula: see text] (read here the Planck length) is far too small to have any direct detection of it feasible, the intrinsic quantum nature of spacetime might anyway be experimentally at reach, witnessed by the mentioned special feature of Ricci, not fading away with [Formula: see text] (i.e. persisting when taking the [Formula: see text] limit).
Upcoming SIGWEB supported conferences
Authors: Roßner Daniel 
Published: December 2021

The Special Interest Group on Hypertext and the Web, SIGWEB was created in 1989 to support the community participating in the annual ACM Hypertext Conference. In its fourth decade, SIGWEB continues its efforts to support a wide range of communities and conferences. Recently, the Web Conference's legal and financial sponsorship was transferred to SIGWEB and thus joins the family of seven annual conferences in 2022. SIGWEB supports several specialized conferences, short courses, and workshops of different sizes, as well as the annual Hypertext Conference. SIGWEB sponsored conferences focus on timely topics in applied and computational hypertext and Web disciplines and provide a place for members and the entire applied Hypermedia and Web community to exchange ideas and to meet with and expand their network of colleagues. In this article, we provide a brief overview of SIGWEB sponsored conferences, in addition to events that are in cooperation with SIGWEB.
Due to the current Corona crisis, many event organizers opted for an online conference format or allow remote participation. These conferences are marked accordingly.
Regular Aspirin Use and Mortality in Patients with Multiple Myeloma
Authors: Marinac Catherine R. , Lee Dong Hoon , Colditz Graham A. , Rebbeck Timothy R. , Rosner Bernard , Bustoros Mark , Ghobrial Irene M. , Birmann Brenda M. 
Published: December 2021

Abstract

Background:
Inflammation is important in multiple myeloma pathogenesis, and regular aspirin use has been shown to confer a reduced risk of multiple myeloma. The influence of aspirin on survival after multiple myeloma diagnosis is unknown.

Methods:
We identified 436 men and women diagnosed with multiple myeloma between 1980 and 2016 in the Health Professionals Follow-up Study and the Nurses' Health Study who reported aspirin intake biennially on follow-up questionnaires. Using multivariable Cox proportional hazards regression models, we estimated HRs and 95% confidence intervals (CI) associated with the effect of aspirin use on multiple myeloma–specific and overall mortality.

Results:
Compared with nonusers, participants who used aspirin after diagnosis had a multivariable HR for multiple myeloma–specific mortality of 0.61 (95% CI, 0.46–0.79) and for overall mortality of 0.63 (95% CI, 0.49–0.80), after adjustment for age at diagnosis, year of diagnosis, sex, body mass index, prediagnosis aspirin use, and number of comorbidities. For postdiagnosis aspirin quantity, we observed a modest trend of reduction in multiple myeloma–specific and all-cause mortality with increasing number of 325-mg tablets of aspirin per week, although the CIs for 1 to &lt;6 and ≥6 tablets overlapped. Results were not materially different before or after the availability of novel therapies (before vs. after the year 2000). Prediagnosis frequency or duration of aspirin use was not significantly associated with multiple myeloma–specific or overall mortality.

Conclusions:
These findings support the use of aspirin as a complementary strategy to enhance multiple myeloma survival.

Impact:
Confirmation in samples that have comprehensive clinical information is encouraged.
Abstract P174: YAP1 drives immune suppression in urothelial carcinoma of bladder
Authors: Sadhukhan Pritam , Feng Mingxiao , Illingworth Emily , Sloma Ido , Ugurlu M. Talha , Sille Fenna , Choi Woonyoung , McConkey David J. , Hoque Mohammad 
Published: December 2021

Abstract
YAP1 is a principal component of the Hippo pathway and is considered as one of the critical regulators of tumorigenesis. Recent studies indicate that YAP1 can suppress the antitumor immunity and influence the differentiation of regulatory T cells (Tregs) by inducing TGFβ/SMAD pathway, but the mechanisms of YAP1 regulated modulation of tumor immune microenvironment is still in its infancy. Most importantly no study has been reported in YAP1 associated immune suppression in UCB. Here, we used syngeneic mouse models with three different mouse bladder cancer cells (MB49, UPPL595 and BBN 975) and demonstrated that YAP1 amplification upregulates the expression of IL-6 in tumor cells in vitro and in vivo, which in turn directly induces immunosuppressive tumor microenvironment (TME). YAP1 expression in cancer cells significantly induces the infiltration of MDSCs and attenuates the CD8 T cells in tumor tissue. YAP1 upregulation also induces different CXCR2 associated ligands and influences the polarization of naive macrophages into M2 type or tumor associated macrophages. Additionally, YAP1 expression enhances cancer stemness properties in the cancer cells and induces the intracellular accumulation of lipid droplets, which may also be a major factor in the development of immunosuppressive TME. Our pilot in vivo studies also suggest that YAP1 downregulation in the tumor cells can stimulate antitumor adaptive immunity in the host and improve tumor immunogenicity, leading to tumor regression. Overall, our results demonstrated the key role of YAP1 in modulating the TME and establish a potential rationale for targeting YAP1 in combination with checkpoint inhibitors for treating UCB.
Citation Format: Pritam Sadhukhan, Mingxiao Feng, Emily Illingworth, Ido Sloma, M. Talha Ugurlu, Fenna Sille, Woonyoung Choi, David J. McConkey, Mohammad Hoque. YAP1 drives immune suppression in urothelial carcinoma of bladder [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2021 Oct 7-10. Philadelphia (PA): AACR; Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P174.
Anatomical properties of Hibiscus macrophyllus and its mature wood development
Authors: Basri Efrida , Damayanti Ratih , Darwis Atmawi , Saefudin  , Wahyudi Imam 
Published: December 2021

Abstract
The Hibiscus macrophyllus tree is widely planted in Indonesia especially on Java Island. It has several advantages to be developed commercially as a community or plantation forest compared to the famous introduced species Falcataria moluccana and Anthocephalus spp., including faster growth, higher wood density, and better stem morphology (straighter, more rounded, and lesser branches). However, information about the basic properties of this wood grown in plantations is limited. This study aimed to investigate the anatomical properties of H. macrophyllus and their variation at three ages (8, 12 and 16 years old), as well as to predict the mature wood development by using radial variation in fiber length, microfibril angle (MFA), and wood density from pith toward the bark as the indicators. The wood samples were obtained from a community forest area at Ciamis Regency, West Java Province. Furthermore, anatomical characteristics were examined through wood slides following the IAWA List, while fibre and vessel element dimensions were measured through macerated specimens prepared by modified Franklin’s method. The MFA was determined by X-Ray Diffraction, while wood density was measured in line with British Standard 373-57. The results showed that the anatomical structures were not influenced by tree age, except for wood porosity, and fibre and vessel element dimensions. The 16-year-old tree tended to be semi-ring-porous, the younger trees were diffuse-porous, while the fiber and vessel element length, as well as the diameter, were decreased. Meanwhile, the wall thickness was increased. The fibre length, MFA, and wood density were useful indicators for wood maturity that seemed to be developed at about 11 years of age.
Molecular phylogeny and diversity of Laburnicola (Didymosphaeriaceae): a new species from Uzbekistan
Authors: HTET ZIN HNIN , MAPOOK AUSANA , GAFFOROV YUSUFJON , CHETHANA K.W. THILINI , LUMYONG SAISAMORN , HYDE KEVIN D. 
Published: December 2021

Laburnicola is a genus in Didymosphaeriaceae that includes saprobic and endophytic fungal taxa. The current study conducted in the subalpine region of Uzbekistan discovered a new species on a dead stem of a wild rose plant. Maximum likelihood and Bayesian analyses of combined LSU, SSU, ITS, and TEF 1-ɑ dataset confirmed the new species’ taxonomic position in Laburnicola. Our new species, Laburnicola zaaminensis (TASM 6152), was clustered with L. dactylidis (MFLUCC 16-0285) with strong bootstrap support. A detailed description together with illustrations are provided for Laburnicola zaaminensis. Furthermore, an annotated species list, a distribution map, and a taxonomic key for Laburnicola species are provided. This is the first record of Laburnicola from Central Asia.
Facilitators and Barriers to Student Learning and Impact of an Undergraduate Clinical Posting in Psychiatry: A Thematic Analysis
Authors: Salazar Luke Joshua , Chari Uttara , Sharma Pratheek , Sreedaran Priya 
Published: December 2021

Background: There is an absence of information on empirical evaluation of undergraduate psychiatry training programs in India. We aimed to evaluate a clinical posting in psychiatry for undergraduate medical students. Methods: We employed levels one and two of Kirkpatrick’s four-level program evaluation model. The qualitative study used written feedback that was collected using a semistructured questionnaire. For quantitative metrics, we used end-of-posting assessment scores and frequencies of standard comments provided by examiners on case-based discussions with students to evaluate their clinical skills. Results: We obtained written feedback from 40 female and 19 male fifth-semester students. We identified facilitators (patient interaction, outpatient department observation and teaching, demonstration of signs, case presentation and discussion, evening posting, observation of clinical work, use of anecdotes while teaching, and lectures by senior faculty) and barriers (organizational issues related to evening posting and disinterest in didactic teaching) to the students learning psychiatry, and the perceived impact of the posting for the students (changed attitudes, knowledge, self-efficacy, and skills acquired). The mean total score on case-based discussion, assigned to 22 groups of students, was 3.86 out of 5. Conclusion: We described the impact of the posting and identified unique facilitators and barriers to students’ learning in psychiatry. These findings will inform the choice of teaching-learning methods in the context of the new Competency-Based undergraduate Medical Education (CBME) curriculum.
Assessment of late gadolinium enhancement-negative chronic total occlusion by longitudinal strain analysis using cardiac magnetic resonance imaging
Authors: Zhang Chen , Li Xin , Mou Anna , Huang RongChong , Song Qingwei , Liu Ailian , Li Zhiyong 
Published: December 2021

Background Strain analysis has become commonly used in clinical practice in various heart diseases. Purpose To explore whether late gadolinium enhancement (LGE)-negative areas with coronary artery chronic total occlusion (CTO) appear normal when analyzed for longitudinal strain using cardiac magnetic resonance (CMR) imaging. Material and Methods A total of 16 patients and 31 healthy controls who underwent 1.5-T MR at our hospital between January 2015 and July 2017 were included in the study. The LGE-CMR of patients with CTO was negative. Left ventricular functional parameters, segmental longitudinal strain/strain rate, and perfusion parameters were measured using CVI42 software. Results For myocardial segments supplied by CTO vessels, systolic longitudinal strain rate (SLSR)was significantly lower than that of healthy controls, and diastolic longitudinal strain rate (DLSR) was significantly higher (1.19 1/s vs. 1.02 1/s; P = 0.018). Moreover, longitudinal strain (LS), SLSR, and DLSR did not differ between good and poor collateral circulation. Perfusion index of CTO territory segments was lower than non-CTO territory segments (0.20 vs. 0.22; P = 0.027). No correlation was found between longitudinal strain parameters and perfusion parameters. Conclusion Although LGE-CMR was negative in patients with CTO, the myocardial SLSR of CTO territory segments was significantly lower than that of healthy controls.
Clinical and radiological results of distal radioulnar joint arthroplasty with the Aptis prosthesis
Authors: Lambrecht Delphine , Vanhove Wim , Hollevoet Nadine 
Published: December 2021

We report the results of the treatment of disorders of the distal radioulnar joint with the semi-constrained Aptis prosthesis. Nineteen patients were assessed at a mean follow-up of 7 years. All patients had been operated on previously at the wrist, forearm or elbow. The Disabilities of Arm, Shoulder and Hand score had a mean value of 40, the Patient-Rated Wrist Evaluation score had a mean of 49 and the visual analogue scale for pain had a mean of 3.9. The mean ranges of pronation, supination, wrist flexion and wrist extension were 78°, 76°, 60° and 51°, respectively. The mean grip strength was 23 kg. Complications were noted in ten patients. Eighteen patients would undergo the operation again. The 10-year cumulative survival rate was 84%. The Aptis prosthesis may be a solution to treat patients in whom previous surgery at the distal radioulnar joint has failed. Level of evidence: IV
Whole-genome sequencing-based phylogeny, antibiotic resistance, and invasive phenotype of Escherichia coli strains colonizing the cervix of women in preterm labor
Authors: Williams Marvin , Jones Alyssa B. , Maxedon Amanda L. , Tabakh Jennifer E. , McCloskey Cindy B. , Bard David E. , Heruth Daniel P. , Chavez-Bueno Susana 
Published: December 2021

AbstractBackgroundEscherichia coliis a major neonatal pathogen and the leading cause of early-onset sepsis in preterm newborns. MaternalE. colistrains are transmitted to the newborn causing invasive neonatal disease. However, there is a lack of data regarding the phenotypic and genotypic characterization ofE. colistrains colonizing pregnant women during labor.MethodsThis prospective study performed at the University of Oklahoma Medical Center (OUHSC) from March 2014 to December 2015, aimed to investigate the colonization rate, and the phylogeny, antibiotic resistance traits, and invasive properties ofE. colistrains colonizing the cervix of fifty pregnant women diagnosed with preterm labor (PTL). Molecular analyses including bacterial whole-genome sequencing (WGS), were performed to examine phylogenetic relationships among the colonizing strains and compare them with WGS data of representative invasive neonatalE. coliisolates. Phenotypic and genotypic antibiotic resistance traits were investigated. The bacteria’s ability to invade epithelial cellsin vitrowas determined.ResultsWe recruited fifty women in PTL. Cervical samples yieldedE. coliin 12 % (n=6). The mean gestational age was 32.5 (SD±3.19) weeks. None delivered an infant withE. colidisease. Phenotypic and genotypic antibiotic resistance testing did not overall demonstrate extensive drug resistance traits among the cervicalE. coliisolates, however, one isolate was multi-drug resistant. The isolates belonged to five different phylogroups, and WGS analyses assigned each to individual multi-locus sequence types. Single nucleotide polymorphism-based comparisons of cervicalE. colistrains with six representative neonatalE. colibacteremia isolates demonstrated that only half of the cervicalE. coliisolates were phylogenetically related to these neonatal invasive strains. Moreover, WGS comparisons showed that each cervicalE. coliisolate had distinct genomic regions that were not shared with neonatalE. coliisolates. Cervical and neonatalE. coliisolates that were most closely related at the phylogenetic level had similar invasion capacity into intestinal epithelial cells. In contrast, phylogenetically dissimilar cervicalE. colistrains were the least invasive among all isolates.ConclusionsThis pilot study showed that a minority of women in PTL were colonized in the cervix withE. coli, and colonizing strains were not phylogenetically uniformly representative ofE. colistrains that commonly cause invasive disease in newborns. Larger studies are needed to determine the molecular characteristics ofE. colistrains colonizing pregnant women associated with an increased risk of neonatal septicemia.
Identification of genes related to tipburn resistance in Chinese cabbage and preliminary exploration of its molecular mechanism
Authors: Yuan Jingping , Shen Changwei , Yuan Ranghua , Zhang Huaixia , Xiao Yan , Wang Xiaoling , Pan Feifei , Wu Chunhui , Li Qingfei , Yuan Jingyun , Liu Xuesheng 
Published: December 2021

Abstract
Background
Tipburn, also known as leaf tip necrosis, is a severe issue in Chinese cabbage production. One known cause is that plants are unable to provide adequate Ca2+ to rapidly expanding leaves. Bacterial infection is also a contributing factor. Different cultivars have varying degrees of tolerance to tipburn. Two inbred lines of Chinese cabbage were employed as resources in this research.

Results
We determined that the inbred line ‘J39290’ was the tipburn resistant material and the inbred line ‘J95822’ was the tipburn sensitive material based on the severity of tipburn, and the integrity of cell membrane structure. Ca2+ concentration measurements revealed no significant difference in Ca2+ concentration between the two materials inner leaves. Transcriptome sequencing technology was also used to find the differentially expressed genes (DEGs) of ‘J95822’ and ‘J39290’, and there was no significant difference in the previously reported Ca2+ uptake and transport related genes in the two materials. However, it is evident through DEG screening and classification that 23 genes are highly linked to plant-pathogen interactions, and they encode three different types of proteins: CaM/CML, Rboh, and CDPK. These 23 genes mainly function through Ca2+-CaM/CML-CDPK signal pathway based on KEGG pathway analysis, protein interaction prediction, and quantitative real-time PCR (qRT-PCR) of key genes.

Conclusions
By analyzing the Ca2+ concentration in the above two materials, the transcription of previously reported genes related to Ca2+ uptake and transport, the functional annotation and KEGG pathway of DEGs, it was found that Ca2+ deficiency was not the main cause of tipburn in ‘J95822’, but was probably caused by bacterial infection. This study lays a theoretical foundation for exploring the molecular mechanism of resistance to tipburn in Chinese cabbage, and has important guiding significance for genetics and breeding.
A novel locus (Bnsdt2) in a TFL1 homologue sustaining determinate growth in Brassica napus
Authors: Li Kaixiang , Xu Liang , Jia Yongpeng , Chen Cuiping , Yao Yanmei , Liu Haidong , Du Dezhi 
Published: December 2021

Abstract
Background
The determinate growth habits is beneficial for plant architecture modification and the development of crops cultivars suited to mechanized production systems. Which play an important role in the genetic improvement of crops. In Brassica napus, a determinate inflorescence strain (4769) has been discovered among doubled haploid (DH) lines obtained from a spring B. napus × winter B. napus cross, but there are few reports on it. We fine mapped a determinate inflorescence locus, and evaluated the effect of the determinate growth habit on agronomic traits.

Results
In this study, we assessed the effect of the determinate growth habit on agronomic traits. The results showed that determinacy is beneficial for reducing plant height and flowering time, advancing maturity, enhancing lodging resistance, increasing plant branches and maintaining productivity. Genetic analysis in the determinate (4769) and indeterminate (2982) genotypes revealed that two independently inherited recessive genes (Bnsdt1, Bnsdt2) are responsible for this determinate growth trait. Bnsdt2 was subsequently mapped in BC2 and BC3 populations derived from the combination 2982 × 4769. Bnsdt2 could be delimited to an approximately 122.9 kb region between 68,586.2 kb and 68,709.1 kb on C09. BLAST analysis of these candidate intervals showed that chrC09g006434 (BnaC09.TFL1) is homologous to TFL1 of A. thaliana. Sequence analysis of two alleles identified two non-synonymous SNPs (T136C, G141C) in the first exon of BnaC09.TFL1, resulting in two amino acid substitutions (Phe46Leu, Leu47Phe). Subsequently, qRT-PCR revealed that BnaC09.TFL1 expression in shoot apexes was significantly higher in NIL-4769 than in 4769, suggesting its essential role in sustaining the indeterminate growth habit.

Conclusions
In this study, the novel locus Bnsdt2, a recessive genes for determinate inflorescence in B. napus, was fine-mapped to a 68,586.2 kb - 68,709.1 kb interval on C09. The annotated genes chrC09g006434 (BnaC09.TFL1) that may be responsible for inflorescence traits were found.
Intravenous infusion route in maternal resuscitation: a scoping review
Authors: Nakamura Eishin , Takahashi Shinji , Matsunaga Shigetaka , Tanaka Hiroaki , Furuta Marie , Sakurai Atsushi ,   the Japan Resuscitation Council (JRC), Guideline Editorial Committee
Published: December 2021

Abstract
Background
The concept that upper extremities can be used as an infusion route during cardiopulmonary resuscitation in pregnant women is a reasonable recommendation considering the characteristic circulation of pregnant women; however, this method is not based on scientific evidence.

Objective of the review
We conducted a scoping review to determine whether the infusion route should be established above the diaphragm during cardiopulmonary resuscitation in a pregnant woman.

Discussion
We included randomized controlled trials (RCTs) and non-RCTs on the infusion of fluids in pregnant women after 20 weeks of gestation requiring establishment of an infusion route due to cardiac arrest, massive bleeding, intra-abdominal bleeding, cesarean section, severe infection, or thrombosis. In total, 3150 articles from electronic database were extracted, respectively. After title and abstract review, 265 articles were extracted, and 116 articles were extracted by full-text screening, which were included in the final analysis. The 116 articles included 78 studies on infusion for pregnant women. The location of the intravenous infusion route could be confirmed in only 17 studies, all of which used the upper extremity to secure the venous route.

Conclusion
Pregnant women undergo significant physiological changes that differ from those of normal adults, because of pressure and drainage of the inferior vena cava and pelvic veins by the enlarged uterus. Therefore, despite a lack of evidence, it seems logical to secure the infusion route above the diaphragm when resuscitating a pregnant woman.