bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposure to Arsenic in the Air and 15-F2t-Isoprostane in Urine in a Sub-population of Inhabitants of a Copper Smelter Region
Authors: Skoczynska Anna , Skoczynska Marta , Turczyn Barbara , Wojakowska Anna , Gruszczynski Leszek , Scieszka Marek 
Published: April 2021

AbstractMost studies on arsenic toxicity have been conducted among populations exposed to arsenic contained in drinking water. Relatively little research concerns effects of airborne arsenic. The aim of this study was to determine whether there is an association between urinary 15-F2t-isoprostane (u15-F2t-IsoP) levels in relation to renal function (urinary creatinine and N-acetyl-β-d-glucosaminidase––uNAG) and urinary arsenic (uAs) in inhabitants from copper smelter impact zone. The secondary purpose of the analysis was to assess utility of a potential association between uAs and u15-F2t-IsoP as a biomarker of systemic oxidative stress. Urinary 15-F2t-IsoP, NAG, and creatinine were measured in 967 urine samples collected from 649 adult women (51.9 ± 13.2 years old) and 318 adult men (53.8 ± 14.9 years old). Total uAs concentration was measured in 918 samples using HPLC-ICP-MS. Arsenic species, such as inorganic arsenic, methylarsonic acid, dimethylarsinic acid, and arsenobetaine, were measured in urine collected from 255 participants with uAs exceeding the upper norm. Data were analyzed using multivariate linear regression and logistic regression models. In the studied population urinary creatinine was positively associated with uAs. A positive linear correlation (p < 0.0000) between lg(uAs) and u15-F2t-IsoP was found both for normal and elevated uAs. A positive linear correlation was observed also between lg(ΣuAs) and u15-F2t-IsoP (p < 0.0000). In the logistic regression model, after adjustment for confounders, elevated uAs was the only predictor of increased u15-F2t-IsoP (OR = 1.31, 95% CI 1.08–1.59,p < 0.01). Cigarette smoking was associated with renal proximal tubular dysfunction only in people with uNAG concentration above 75th quartile. In the studied population chronically exposed to airborne arsenic, increase in urinary arsenic is associated with renal dysfunction and systemic oxidative stress. Urinary 15-F2t-isoprostane may be useful in the monitoring of health status in populations exposed to airborne arsenic.
Smart Roads Geometric Design Criteria and Capacity Estimation Based on AV and CAV Emerging Technologies. A Case Study in the Trans-European Transport Network
Authors: Guerrieri Marco 
Published: April 2021

AbstractSmart roads, AV and CAV are emerging technologies that represent the new paradigm of mobility. To support the public and private road operators better prepare themselves to implement these technologies in their respective existing or planned infrastructures, there is an urgent need to develop an integrated analysis framework to evaluate the impact of these novel systems on road capacity and safety in function of different market penetration levels of AVs and CAVs. The research focuses on novel smart road geometric design and review criteria based on the performance of AVs and CAVs. The case study of one of the first planned smart roads in Italy has been analysed.
Evaluation of the performance of titanium and zirconium salts as coagulants in industrial wastewater treatment: pollutant removal, sludge production, and sludge characteristics
Authors: Uysal Ayla , Boyacioglu Eda 
Published: April 2021

AbstractIn this study, titanium tetrachloride (TiCl4), zirconium tetrachloride (ZrCl4), and zirconium oxychloride (ZrOCl2·8H2O) were evaluated using jar test experiments as coagulants and compared with traditional aluminum sulfate (Al2(SO4)3·18H2O) and ferric chloride (FeCl3) for industrial wastewater treatment. The effects of the initial pH of 4–10 and initial coagulant doses of 10–100 mg/L on chemical oxygen demand (COD) and total suspended solids (TSS) removal were investigated. The performances of the five coagulants were also assessed in terms of the settled sludge volume, the sludge volume index (SVI), and removal efficiencies of metals, color, and total phosphorus (TP) under optimum conditions. In addition, the contents of the residual sludge produced for all five tested coagulants under optimum conditions were determined. The results showed that the maximum removal efficiency of COD (69.33%) was achieved using 100 mg/L TiCl4 at pH 8. The maximum removal efficiency of TSS (98.32%) was achieved using 50 mg/L Al2(SO4)3·18H2O at both pH 8 and 10. The settled sludge volume and SVI generated by TiCl4 were lower than that for the other four tested coagulants. ZrCl4, ZrOCl2·8H2O, FeCl3, and Al2(SO4)3·18H2O resulted in 128.13, 92.39, 72.26, and 69.66 mL/g SVI, while that using TiCl4 was 48.84 mL/g. Ti- and Zr-based coagulants achieved better removal efficiencies of TP, Zn, and Cu than FeCl3 and Al(SO4)3·18H2O. The residual sludge from using Ti and Zr coagulants had a very high TP content. The results indicated that Ti- and Zr-based coagulants could be used as alternatives to traditional coagulants for industrial wastewater treatment.
Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon
Authors: Sun Yue , Wang Qi , Wang Yi , Ren Wenran , Cao Ying , Li Jiali , Zhou Xin , Fu Wei , Yang Jing 
Published: April 2021

AbstractAxonal degeneration is one of the key features of neurodegenerative disorders. In the canonical view, axonal degeneration destructs neural connections and promotes detrimental disease defects. Here, we assessed the enteric nervous system (ENS) of the mouse, non-human primate, and human by advanced 3D imaging. We observed the profound neurodegeneration of catecholaminergic axons in human colons with ulcerative colitis, and similarly, in mouse colons during acute dextran sulfate sodium-induced colitis. However, we unexpectedly revealed that blockage of such axonal degeneration by the Sarm1 deletion in mice exacerbated the colitis condition. In contrast, pharmacologic ablation or chemogenetic inhibition of catecholaminergic axons suppressed the colon inflammation. We further showed that the catecholaminergic neurotransmitter norepinephrine exerted a pro-inflammatory function by enhancing the expression of IL-17 cytokines. Together, this study demonstrated that Sarm1-mediated neurodegeneration within the ENS mitigated local inflammation of the colon, uncovering a previously-unrecognized beneficial role of axonal degeneration in this disease context.
Stable Lithium-Carbon Composite Enabled by Dual-Salt Additives
Authors: Zheng Lei , Guo Feng , Kang Tuo , Fan Yingzhu , Gu Wei , Mao Yayun , Liu Ya , Huang Rong , Li Zhiyun , Shen Yanbin , Lu Wei , Chen Liwei 
Published: April 2021

AbstractLithium metal is regarded as the ultimate negative electrode material for secondary batteries due to its high energy density. However, it suffers from poor cycling stability because of its high reactivity with liquid electrolytes. Therefore, continuous efforts have been put into improving the cycling Coulombic efficiency (CE) to extend the lifespan of the lithium metal negative electrode. Herein, we report that using dual-salt additives of LiPF6 and LiNO3 in an ether solvent-based electrolyte can significantly improve the cycling stability and rate capability of a Li-carbon (Li-CNT) composite. As a result, an average cycling CE as high as 99.30% was obtained for the Li-CNT at a current density of 2.5 mA cm–2 and an negative electrode to positive electrode capacity (N/P) ratio of 2. The cycling stability and rate capability enhancement of the Li-CNT negative electrode could be attributed to the formation of a better solid electrolyte interphase layer that contains both inorganic components and organic polyether. The former component mainly originates from the decomposition of the LiNO3 additive, while the latter comes from the LiPF6-induced ring-opening polymerization of the ether solvent. This novel surface chemistry significantly improves the CE of Li negative electrode, revealing its importance for the practical application of lithium metal batteries.
An inverse Jacobian algorithm for Picard curves
Authors: Lario Joan-C. , Somoza Anna , Vincent Christelle 
Published: April 2021

AbstractWe study the inverse Jacobian problem for the case of Picard curves over$${\mathbb {C}}$$C. More precisely, we elaborate on an algorithm that, given a small period matrix$$\varOmega \in {\mathbb {C}}^{3\times 3}$$Ω∈C3×3corresponding to a principally polarized abelian threefold equipped with an automorphism of order 3, returns a Legendre–Rosenhain equation for a Picard curve with Jacobian isomorphic to the given abelian variety. Our method corrects a formula obtained by Koike–Weng (Math Comput 74(249):499–518, 2005) which is based on a theorem of Siegel. As a result, we apply the algorithm to obtain equations of all the isomorphism classes of Picard curves with maximal complex multiplication by the maximal order of the sextic CM-fields with class number at most$$4$$4. In particular, we obtain the complete list of maximal CM Picard curves defined over$${\mathbb {Q}}$$Q. In the appendix, Vincent gives a correction to the generalization of Takase’s formula for the inverse Jacobian problem for hyperelliptic curves given in [Balakrishnan–Ionica–Lauter–Vincent, LMS J. Comput. Math., 19(suppl. A):283-300, 2016].
Effective estimation algorithm for parameters of multivariate Farlie–Gumbel–Morgenstern copula
Authors: Ota Shuhei , Kimura Mitsuhiro 
Published: April 2021

AbstractThis paper focuses on the parameter estimation for the d-variate Farlie–Gumbel–Morgenstern (FGM) copula ($$d\ge 2$$

d
≥
2

), which has $$2^d-d-1$$

2
d

-
d
-
1

dependence parameters to be estimated; therefore, maximum likelihood estimation is not practical for a large d from the viewpoint of computational complexity. Besides, the restriction for the FGM copula’s parameters becomes increasingly complex as d becomes large, which makes parameter estimation difficult. We propose an effective estimation algorithm for the d-variate FGM copula by using the method of inference functions for margins under the restriction of the parameters. We then discuss its asymptotic normality as well as its performance determined through simulation studies. The proposed method is also applied to real data analysis of bearing reliability.
Burnout and Sources of Stress Among Health Care Risk Managers and Patient Safety Personnel During the COVID-19 Pandemic: A Pilot Study
Authors: Card Alan J. 
Published: April 2021

AbstractObjective:This study investigates burnout and sources of stress related to the coronavirus disease 2019 (COVID-19) pandemic among a group of health care risk managers/patient safety practitioners.Methods:An online survey was used, including the Oldenburg Burnout Inventory (OLBI) and 1 open-ended question: Since the start of the COVID-19 pandemic, what work or non-work-related issues have been causing you the most stress?Results:A total of 31 participants completed the OLBI; 27 answered the open-ended question. Over 70% of participants qualified as burned out. A thematic analysis was used to analyze stressors. Key themes included impacts of social distancing, changing duties and workload, real and potential impacts of the virus (eg, fear of infection for self or others), and financial concerns (personal and organizational). Less common themes included untrustworthy and constantly changing guidance, feeling abused by persons in power, and positive comments about the experience of working during the pandemic.Conclusion:Burnout and pandemic-related stress may be very common in the health care risk management and patient safety workforce. Additional research is required to more robustly estimate the prevalence of burnout in this population. Meanwhile, the sources of stress identified here may aid health care organizations in taking immediate action to protect this vital workforce.
Addressing Pediatric Mental Health During COVID-19 and Other Disasters: A National Tabletop Exercise
Authors: Gupta Saloni , Schreiber Merritt , McGuire Tona , Newton Christopher 
Published: April 2021

AbstractObjective:In the wake of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, rapid identification of pediatric mental health risk is extremely important. The Western Regional Alliance for Pediatric Emergency Management held an integrated, interdisciplinary national tabletop exercise to familiarize mental health and non-mental health professionals with Psychological Simple Triage and Rapid Treatment (PsySTART), an evidence-based triage and incident management system used to evaluate new mental health risk impacts following exposure to traumatic events, such as coronavirus disease (COVID-19).Methods:Participants Participants were exposed to 3 practice cases that reflected a combination of “all hazards” scenarios and were asked to triage each case using PsySTART. Participants were asked to interpret results at both an individual site and aggregate county and/or state level.Results:The exercise had a total of 115 participants with a total of 156 discrete triage encounters. A user-defined operating picture was created with graphs of aggregate mental health risk data, generating cross-regional, real-time situational awareness. After the exercise, a vast majority of the participants reported confidence in their ability to use PsySTART in their practices.Conclusions:Participants are now better equipped with tools to perform mental health triage for early intervention during COVID-19 and other disasters and understand risk on a population level.
Searching for a middle ground? A spectrum of views of causality in qualitative research
Authors: Ruffa Chiara , Evangelista Matthew 
Published: April 2021

AbstractQualitative scholars exhibit a wide range of views on and approaches to causality. While some approaches reject causality from the outset, a large strand of qualitative research in political science and international relations does, however, pursue causal explanation. Qualitative scholars nevertheless disagree about what causality means. Our paper reviews what causality means within different strands of qualitative research and how qualitative scholars engage in causal explanations. We focus particular attention on the fertile middle ground between qualitative research that seeks to mimic the statistical model and research that rejects causality entirely. In broad strokes, we understand views of causality as lying on a spectrum and partly overlapping. Along the spectrum, we identify three main clusters: ‘positivist leaning,’ ‘postpositivist leaning,’ and ‘interpretivist leaning.’ Within each cluster, we identify the main traits and provide illustrative examples. We find merit in each of these three clusters of approaches and in the ongoing dialogue among qualitative scholars of different orientations. Understanding similarities and differences in the way various scholars address causality might encourage some to take steps along the spectrum and expand their repertoires to embrace elements of other approaches. By making these distinctions more explicit, we hope to be able to enhance our understanding of different views of causality and the extent to which they overlap and provide the potential for collaboration.
Poor adherence to the Mediterranean diet is associated with increased likelihood of metabolic syndrome components in children: the Healthy Growth Study
Authors: George Elena S , Gavrili Stavroula , Itsiopoulos Catherine , Manios Yannis , Moschonis George 
Published: April 2021

AbstractObjective:To examine the associations between the level of adherence to the Mediterranean diet (MedDiet) with obesity, insulin resistance (IR), metabolic syndrome (MetS) and its components in schoolchildren.Design:The Healthy Growth Study was a large epidemiological cross-sectional study.Setting:School children who were enrolled in primary schools in four counties covering the northern, southern, western and central part of Greece were invited to participate.Participants:The study was conducted with a representative sample of 9–13-year-old schoolchildren (n 1972) with complete data. This study applied the KIDMed score to determine ‘poor’ (≤3), ‘medium’ (4-7) and ‘high’ (≥8) adherence of children to the MedDiet. The research hypothesis was examined using multivariate logistic regression models, controlling for potential confounders.Results:The percentage of children with ‘poor’, ‘medium’ and ‘high’ adherence to the MedDiet was 64·8 %, 34·2 % and 1 %, respectively. Furthermore, the prevalence of obesity, IR and MetS was 11·6 %, 28·8 % and 3·4 %, respectively. Logistic regression analyses revealed that ‘poor’ adherence to the MedDiet was associated with an increased likelihood for central obesity (OR 1·31; 95 % CI 1·01, 1·73), hypertriglyceridaemia (OR 2·80; 95 % CI 1·05, 7·46) and IR (OR 1·31; 95 % CI 1·05, 1·64), even after adjusting for several potential confounders.Conclusions:The present study showed that approximately two-thirds of the examined sample of schoolchildren in Greece have ‘poor’ adherence to the MedDiet, which also increases the likelihood for central obesity, hypertriglyceridaemia and IR. Prospective studies are needed to confirm whether these are cause–effect associations.
What stops us from eating: a qualitative investigation of dietary barriers during pregnancy in Punjab, Pakistan
Authors: Asim Muhammad , Ahmed Zarak H , Nichols Amy R , Rickman Rachel , Neiterman Elena , Mahmood Anita , Widen Elizabeth M 
Published: April 2021

AbstractObjective:Adequate dietary intake during pregnancy is vital for the health and nutritional status of both mother and fetus. The nutritional status of reproductive age women in Pakistan is poor, with 14 % being underweight (BMI < 18·5) and 42 % experiencing Fe deficiency anaemia. This may stem from beliefs, practices and other barriers influencing dietary intake. This qualitative study seeks to determine which factors impact dietary intake during pregnancy in rural Punjab.Design:In-depth interviews and focus group discussions were conducted and then analysed using thematic analysis.Setting:Three purposively selected rural districts (Sahiwal, Okara and Pakpatan) with the highest prevalence of maternal and child malnutrition in the province of Punjab, PakistanParticipants:Mothers with children under age two (n 29) and healthcare providers with at least 5 years of experience working in the district (n 12).Results:We identified a combination of physiological, socio-cultural and structural barriers that inhibited healthful dietary intake during pregnancy. The primary physiological barriers to optimal dietary intake and dietary practices included food aversions and food cravings. Food classification, fear of a difficult childbirth, fear of high blood pressure and household food politics were the principal socio-cultural barriers. Additionally, two structural barriers, inadequate antenatal counseling and a lack of affordable food options, were identified.Conclusions:Our study demonstrates that complex barriers prevent pregnant women in the Punjab area from consuming adequate dietary intake and that antenatal health education programmes and structural interventions are needed to support healthful dietary practices during this critical period.
Potential of a Gravity‐Driven Film Flow Model to Predict Infiltration in a Catchment for Diverse Soil and Land Cover Combinations
Authors: Demand D. , Weiler M. 
Published: April 2021

AbstractApplying physically based models that include preferential flow (PF) is still very challenging at the catchment scale. A gravity‐driven film flow approach could be a promising concept for modeling PF as it only requires a small number of parameters. We tested if this approach can be used for different soils and land covers within a 247 km2 catchment and if we can find generalizable relationships of the film flow parameters to site or rainfall properties. We used a unique data set from a soil moisture sensor network with 135 instrumented soil profiles in three different geologies (slate, marl, and sandstone) and two land covers (forest and grassland) and fitted the film flow model to around 1,700 infiltration events. The results demonstrate that the physical relationship of film flow was capable to predict wetting front velocity (v) and flow parameters from rainfall input (qs) alone. This relationship was pronounced in grassland sites but weaker for forest sites, probably due to heterogeneity of the rainfall input underneath the canopy. Incorporating the water content into the v‐qs relationship did not improve the quality, but showed that for the film flow the rainfall input and hence gravity is in fact the dominant driver and not capillarity. Furthermore, abstraction of water into the soil matrix during film flow is an important process to be included into the framework with reasonable agreements for marl and sandstone using a multiple linear regression. Film flow and corresponding functional parameter relationships for other regions could improve catchment wide PF modeling in the future.
Fates and Use Efficiency of Nitrogen Fertilizer in Maize Cropping Systems and Their Responses to Technologies and Management Practices: A Global Analysis on Field 15N Tracer Studies
Authors: Quan Zhi , Zhang Xin , Davidson Eric A. , Zhu Feifei , Li Shanlong , Zhao Xinghan , Chen Xin , Zhang Li‐Mei , He Ji‐Zheng , Wei Wenxue , Fang Yunting 
Published: April 2021

AbstractNitrogen (N) fertilization has boosted grain production during the past century, while excess N fertilization with declining N use efficiency (NUE) has led to severe pollution in many regions. To achieve the goal of sustainable food production, Technologies and Management Practices (TMPs, e.g., optimum N application rate and methods, N‐transformation inhibitors) have been developed to improve crop yield and NUE and to reduce N losses. However, it remains unclear how N fate has been changed by environmental factors and TMPs. Here, we compiled a dataset of 366 field 15N tracer observations from 74 publications worldwide and conducted a meta‐analysis to examine how environmental conditions and management practices influence the fertilizer‐N fate one growing season after the fertilization of maize. We show that the proportion of 15N taken up by aboveground biomass (NUE15N), was significantly lower in China (33%) than that in North America (42%) and the European Union (54%). Soil organic carbon was the most critical environmental factor positively correlated with NUE15N. Among the nine selected categories of TMPs, deep placement of fertilizer and split application increased the grain yield and decreased the fertilizer‐N loss consistently among studies. Reducing the fertilizer‐N rate could increase the NUE15N but presents risks of yield reduction in some regions. This study demonstrates the importance of SOC and varying impacts of TMPs on the efficiency of fertilizer use in cropping systems globally and provides critical information for farmers and policymakers to improve N management for higher productivity and less pollution.