bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19
Authors: Briggs Neima , Gormally Michael V. , Li Fangyong , Browning Sabrina L. , Treggiari Miriam M. , Morrison Alyssa , Laurent-Rolle Maudry , Deng Yanhong , Hendrickson Jeanne E. , Tormey Christopher A. , Desruisseaux Mahalia S. 
Published: July 2021

Background
Limited therapeutic options exist for coronavirus disease 2019 (COVID-19). COVID-19 convalescent plasma (CCP) is a potential therapeutic, but there is limited data for patients with moderate-to-severe disease.

Research question
What are outcomes associated with administration of CCP in patients with moderate-to-severe COVID-19 infection?

Study design and methods
We conducted a propensity score-matched analysis of patients with moderate-to-severe COVID-19. The primary endpoints were in-hospital mortality. Secondary endpoints were number of days alive and ventilator-free at 30 days; length of hospital stay; and change in WHO scores from CCP administration (or index date) to discharge. Of 151 patients who received CCP, 132 had complete follow-up data. Patients were transfused after a median of 6 hospital days; thus, we investigated the effect of convalescent plasma before and after this timepoint with 77 early (within 6 days) and 55 late (after 6 days) recipients. Among 3,217 inpatients who did not receive CCP, 2,551 were available for matching.

Results
Early CCP recipients, of whom 31 (40%) were on mechanical ventilation, had lower 14-day (15% vs 23%) and 30-day (38% vs 49%) mortality compared to a matched unexposed cohort, with nearly 50% lower likelihood of in-hospital mortality (HR 0.52, [95% CI 0.28–0.96]; P = 0.036). Early plasma recipients had more days alive and ventilator-free at 30 days (+3.3 days, [95% CI 0.2 to 6.3 days]; P = 0.04) and improved WHO scores at 7 days (-0.8, [95% CI: -1.2 to -0.4]; P = 0.0003) and hospital discharge (-0.9, [95% CI: -1.5 to -0.3]; P = 0.004) compared to the matched unexposed cohort. No clinical differences were observed in late plasma recipients.

Interpretation
Early administration of CCP improves outcomes in patients with moderate-to-severe COVID-19, while improvement was not observed with late CCP administration. The importance of timing of administration should be addressed in specifically designed trials.
Factors associated with school achievement of children aged 8–10 years in rural Bangladesh: Findings from a post hoc analysis of a community-based study
Authors: Hossain Sheikh Jamal , Tofail Fahmida , Sujan Hasan Mahmud , Arifeen Shams El , Hamadani Jena 
Published: July 2021

BackgroundEducation is one of the most important human capitals. Investment in education at early age returns best. A lot of factors influence children’s educational achievement. Studies in developed countries well established the relation of school achievement with its associated variables. But information is lack on what factors play important role for school achievement at early age in low resource settings like Bangladesh. We aimed to find factors associated with school achievement in rural Bangladesh.MethodThe data were acquired from a long-term follow up study, conducted in 8–10 years old children (n = 372). We used a locally developed school achievement tool based on Wide Range Achievement Test-4 to measure reading, spelling and math computation, Wechsler abbreviated scale of intelligence to measure intelligence Quotient (IQ), Digit span forward and backward for short term memory, and locally available Strength and Difficulties Questionnaire to measure behaviour. Socioeconomic and anthropometric information of the mothers and children were also collected. Multicollinearity of the data was checked. Unadjusted and adjusted multiple linear regression analysis was performed.FindingsYears of schooling and short-term memory were positively related to reading, spelling and math computation. For years of schooling it was-reading B = 8.09 (CI 5.84, 10.31), spelling 4.43 (4.33, 8.53) and math computation 5.23 (3.60, 6.87) and for short term memory- reading 3.56 (2.01,5.05), spelling 4.01 (2.56, 5.46) and math computation 2.49 (1.37, 3.62). Older children had lower scores of reading -0.48 (-0.94, -0.02), spelling -0.41 (-0.88, -0.02) and math computation -0.47 (-0.80, -0.14). Children’s IQ predicted reading 0.48 (0.14, 0.81) and spelling 0.50 (0.18, 0.82) skills. Mother and father’s education predicted Spelling 0.82 (0.16, 1.48) and reading 0.68 (0.06, 1.30) capacity respectively. Children enrolled in private schools had higher reading 10.28 (5.05, 15.51) and spelling 6.22 (1.31, 11.13) than those in the government schools. Children with more difficult behaviour tended to have lower scores in reading -0.51 (-0.96, -0.05).ConclusionChildren’s school achievement is influenced by their IQ, years of schooling, type of school and parents’ education. Therefore, intervention should be made to focus specifically on these variables and establish the effect of this intervention through robust research design.
A drug comorbidity index to predict mortality in men with castration resistant prostate cancer
Authors: Fallara Giuseppe , Gedeborg Rolf , Bill-Axelson Anna , Garmo Hans , Stattin Pär 
Published: July 2021

Background
The Charlson Comorbidity Index is a poor predictor of mortality in men with castration resistant prostate cancer (CRPC). To improve this prediction, we created a comorbidity index based on filled prescriptions intended to be used in registry-based studies.

Materials and methods
In a population-based cohort of men with CPRC a drug comorbidity index (DCI-CRPC) was calculated based on prescriptions filled during a 365-day period before the date of CRPC diagnosis to predict mortality. Five risk categories for men with CRPC were defined based on PSA kinetics. Mortality rates were described by Kaplan-Meier curves. The predictive ability of the DCI-CRPC was compared in univariable models to that of the original DCI, derived from men in the general population, and to that of the Charlson Comorbidity Index.

Results
In 1,885 men with CRPC the median overall survival ranged from 3.0 years (95% confidence interval [CI] 2.8 to 3.4) in the first tertile of the DCI-CRPC, to 1.0 year (95% CI 0.9 to 1.1) in the third tertile of the DCI-CRPC. The index had higher discriminative ability (C-index 0.667) than the Charlson Comorbidity Index (C-index 0.508). The discriminative ability of the DCI-CRPC was highest in the subgroup with least aggressive cancer (C-index 0.651) and lowest in men with most aggressive cancer (C-index 0.618). The performance of the DCI-CRPC was comparable to that of the original DCI.

Conclusion
Our newly created comorbidity index using filled prescriptions predicted death in men with CRPC better than the Charlson Comorbidity Index.
Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson’s disease
Authors: Taguchi Soutarou , Koide Hirofumi , Oiwa Hiroko , Hayashi Miku , Ogawa Kazuhiro , Ito Chihiro , Nakashima Koji , Yuasa Tomoko , Yasumoto Akihiro , Ando Hiroaki , Fujikake Akifumi , Fukuoka Takaaki , Tokui Keisuke , Izumi Masayuki , Tsunoda Yuka , Kawagashira Yuichi , Okada Yohei , Niwa Jun-ichi , Doyu Manabu 
Published: July 2021

Objective
To clarify whether antiparkinsonian drugs contribute to nocturnal sleep disturbances in patients with Parkinson’s disease (PD).

Background
Although the major antiparkinsonian drugs L-dopa and dopamine agonists (DAs) have been found to affect sleep, little is known about the effects of specific drugs on sleep in PD patients.

Methods
The study participants consisted of 112 PD patients (median age 72.5 years [inter-quartile range: IQR 65–79]; mean disease duration 8.44 years [standard deviation: 7.33]; median Hoehn and Yahr stage 3 [IQR 2–3.75]) taking one of three types of non-ergot extended-release DAs (rotigotine 32; pramipexole 44; ropinirole 36) with or without L-dopa (median daily total dosage of antiparkinsonian drugs 525.5 mg [IQR 376.25–658] levodopa equivalent dose [LED]). Participants were assessed using the PD Sleep Scale-2 (PDSS-2).

Results
For the whole PD patient cohort, the PDSS-2 sleep disturbance domain score and the scores for item 1 assessing sleep quality and item 8 assessing nocturia were positively correlated with daily total dosage of antiparkinsonian drugs and dosage of L-dopa, but not with the dosage of DAs. Sub-analysis according to DA treatment revealed that DA dosage was not correlated with item 1 or 8 score in any of the subgroups. The LED ratio of rotigotine to the total dosage of antiparkinsonian drugs was inversely correlated with the item 1 score.

Conclusions
These data suggest that antiparkinsonian drugs, in particular L-dopa, adversely affect nocturnal sleep in PD patients, especially in terms of sleep quality and nocturia. Thus, adjusting both the total dosage of antiparkinsonian drugs and the dose-ratio of L-dopa might be key actions for alleviating poor sleep quality in patients with PD. Among DAs, we found a clear positive correlation between the dose-ratio of rotigotine and sleep quality. Thus, partial L-dopa replacement with rotigotine could improve sleep quality in patients with PD.
A WSQ-based mobile peer assessment approach to enhancing university students’ vocal music skills and learning perceptions
Authors: Liu Chenchen , Wan Ping , Tu Yun-Fang , Chen Kai , Wang Youmei 
Published: July 2021

Peer assessment has been regarded as an effective learning strategy in art education, such as in music, dance and art design. For music education, technology-supported peer assessment makes it easier for learners to reflect on their learning performance. However, the process of reflection needs solid and systematic theoretical knowledge. In terms of vocal music, which develops students’ singing skills, it is difficult for learners to compare their own works with those of others because of a lack of sufficient theoretical knowledge. Therefore, a WSQ (watch-summary-question)-based mobile peer assessment approach was used to help learners reflect based on their theoretical knowledge with the support of WSQ learning sheets. To investigate the effectiveness of the approach, an experiment was carried out in a Chinese university. The experimental group (N = 22) learned with the WSQ approach, whereas the control group (N = 22) adopted a mobile peer assessment approach without WSQ. Vocal music skills, learning attitude and learning motivation were assessed. The experimental results indicate that the approach effectively enhanced the students’ vocal music skills but did not improve their learning motivation or attitude. In addition, a higher correlation between teacher scoring and peer scoring was found for the experimental group.
Implications for practice or policy:

Technology has a great potential in supporting art education and integrating technology into vocal music education should follow the rules of music education.
Developing students’ reflective thinking skills in vocal music education is challenging, but attainable; it needs considered instructional design and sustained efforts from students.
Global existence and dynamic structure of solutions for damped wave equation involving the fractional Laplacian
Authors: Bidi Younes , Beniani Abderrahmane , Zennir Khaled , Himadan Ahmed 
Published: July 2021

Abstract
We consider strong damped wave equation involving the fractional Laplacian with nonlinear source. The results of global solution under necessary conditions on the critical exponent are established. The existence is proved by using the Galerkin approximations combined with the potential well theory. Moreover, we showed new decay estimates of global solution.
Fermentative Production of Mannosylerythritol Lipids using Sweetwater as Waste Substrate by Pseudozyma antarctica (MTCC 2706)
Authors: Mawani Jayata , Jadhav Jagruti , Pratap Amit 
Published: July 2021

Abstract
Mannosylerythritol lipids are glycolipid biosurfactants with promising industrial applications. However, their commercial production is hindered due to its high production cost. The current study investigates the use of sweetwater, a by-product of the fat-splitting industry in combination with soybean oil for the production of mannosylerythritol lipids using Pseudozyma antarctica (MTCC 2706). The optimum sweetwater and soybean oil concentration of 22% and 7% (w/v) yielded 7.52 g L–1and 21.5 g L–1 mannosylerythritol lipids at shake flask and fermenter level respectively. The structure and functional groups of mannosylerythritol lipids were confirmed by fourier transform infrared (FTIR) spectroscopy, liquid chromatography-mass spectrometry (LC/MS) and 1H- and 13C-nuclear magnetic resonance (NMR) analysis. Surfactant properties, such as surface tension, critical micelle concentration, foaming and emulsification of mannosylerythritol lipids were also explored.
A háborús nemi erőszak és a nőgyógyász lobbi hatása a magyarországi születésszabályozási rendszerre
Authors: Pető Andrea , Svégel Fanni 
Published: July 2021

A tanulmány bemutatja, hogyan kapcsolódott össze a születésszabályozás és születéskorlátozás a tömeges nemi erőszakkal az első és a második világháborúban, továbbá hogyan erősítette fel a korábban is meglevő vitákat a nemi erőszak jelensége, illetve ennek milyen törvényi és a nők életdöntéseit befolyásoló gyakorlati következményei voltak. Az első világháború során elkövetett nemierőszak-esetek indították el a nyilvános szakpolitikai vitákat, amelyek nyomán fokozatosan egyre nagyobb teret engedtek a terhesség legális megszakításának. Az 1945-ös tömeges katonai erőszak pedig precedensértékű legalizációt hozott magával, ami után a magyar szabályozás a váltakozó szovjet családpolitikát követte. A cikk bemutatja, hogy a szülész–nőgyógyász lobbi hogyan vett részt a vitákban, illetve hogyan volt képes szakmai és anyagi érdekeit az éppen aktuális szakpolitikai döntések során is képviselni, például az 1952-es népesedéspolitikai kampány során. Az abortuszbizottságok és társadalmi szerepük meghatározónak bizonyultak legalább egy nőgeneráció számára. Az ötvenes évek elején megkezdődő erőteljes medikalizáció és adminisztrációs ellenőrzés a hetvenes évekre megváltoztatta a születésszabályozási rendszert: a terhességmegszakítások dominanciáját fokozatosan felváltotta a modern fogamzásgátló szerek széleskörű használata. Az újabb népesedéspolitikai kampány (1973) és a civil ellenállás, majd a rendszerváltást követő alkotmányos szabályozás körüli kiélezett viták mutatják a mára létrejött kényes egyensúly törékenységét és a kompromisszumos megoldás egyfajta lehetőségét.
Fotó: Fortepan / Urbán Tamás
Rapid Inhibition Accuracy and Leg Strength Are Required for Community-Dwelling Older People to Recover Balance From Induced Trips and Slips: An Experimental Prospective Study
Authors: Okubo Yoshiro , Duran Lionne , Delbaere Kim , Sturnieks Daina L. , Richardson James K. , Pijnappels Mirjam , Lord Stephen R. 
Published: July 2021

Background and Purpose:
Falls can result in bone fractures and disability, presenting a serious threat to quality of life and independence in older adults. The majority of falls in community-living older adults occur while walking and are often caused by trips and slips. The study aimed to identify the specific sensorimotor and psychological factors required for older adults to recover balance from trips and slips.

Methods:
Forty-one older adults aged 65 to 87 years were assessed on sensorimotor (knee extension strength, proprioception, postural sway, and edge contrast sensitivity), reaction (simple reaction time, stepping, and catching reaction inhibition), and psychological (general anxiety and concern about falling) measures. Using a harness system, participants walked at 90% of their usual pace on a 10-m walkway that could induce trips and slips in concealed and changeable locations. Post-perturbation responses resulting in more than 30% of body weight being recorded by the harness system were defined as falls. Poisson regressions were used to test associations between the sensorimotor, reaction, and psychological measures and number of falls.

Results:
Fifty-one falls occurred in 25 of 41 participants. Poisson regression revealed body mass index, lower-limb proprioception, knee extension strength, rapid inhibition accuracy, concern about falling, and anxiety were significantly associated with the rate of falls. Other measures including postural sway were not statistically significant. Using stepwise Poisson regression analyses, normalized knee extension strength (rate ratio [RR]: 0.68, 95% confidence interval [CI]: 0.47-0.98), and rapid inhibition accuracy (RR: 0.64, 95% CI: 0.46-0.87) were independently associated with falls.

Conclusion:
Our findings suggest rapid inhibition accuracy and adequate leg strength are required for older adults to recover balance from trips and slips. The mechanisms for balance recovery during daily life activities are likely different from those for static balance, suggesting the need for task-specific assessments and interventions for fall prevention in older adults.
Effects of Alternating Unilateral vs. Bilateral Resistance Training on Sprint and Endurance Cycling Performance in Trained Endurance Athletes: A 3-Armed, Randomized, Controlled, Pilot Trial
Authors: Ji Sanghyeon , Donath Lars , Wahl Patrick 
Published: July 2021

Abstract
Ji, S, Donath, L, and Wahl, P. Effects of alternating unilateral vs. bilateral resistance training on sprint and endurance cycling performance in trained endurance athletes: A 3-armed, randomized, controlled, pilot trial. J Strength Cond Res 36(12): 3280–3289, 2022—Traditional preparatory resistance training for cyclists mainly relies on simultaneous bilateral movement patterns. This lack of movement specificity may impede transfer effects to specific aerobic and anaerobic requirements on the bike. Hence, this study investigated the effects of resistance training in alternating unilateral vs. simultaneous bilateral movement pattern on strength and anaerobic as well as aerobic cycling performance indices. Twenty-four trained triathletes and cyclists (age: 31.1 ± 8.1 years; V̇o
2max: 57.6 ± 7.1 ml·min−1·kg−1) were randomly assigned to either an alternating unilateral (AUL), a simultaneous bilateral (BIL) training group or a control group (CON). Ten weeks of resistance training (4 × 4–10 repetition maximum) were completed by both training groups, although CON maintained their usual training regimen without resistance training. Maximal strength was tested during isometric leg extension, leg curl, and leg press in both unilateral and bilateral conditions. To compare the transfer effects of the training groups, determinants of cycling performance and time to exhaustion at 105% of the estimated anaerobic threshold were examined. Maximal leg strength notably increased in both training groups (BIL: ∼28%; AUL: ∼27%; p < 0.01) but not in CON (∼6%; p > 0.54). A significant improvement in cycling time trial performance was also observed in both training groups (AUL: 67%; BIL: 43%; p < 0.05) but not for CON (37%; p = 0.43). Bilateral group exhibited an improved cycling economy at submaximal intensities (∼8%; p < 0.05) but no changes occurred in AUL and CON (∼3%; p > 0.24). While sprint cycling performance decreased in CON (peak power: −6%; acceleration index: −15%; p < 0.05), improvement in favor of AUL was observed for acceleration abilities during maximal sprinting (20%; d = 0.5). Our pilot data underpin the importance of resistance training independent of its specific movement pattern both for improving the endurance cycling performance and maximal leg strength. Further research should corroborate our preliminary findings on whether sprint cycling benefits favorably from AUL resistance training.
Strong, Fast, Fit, Lean, and Safe: A Positional Comparison of Physical and Physiological Qualities Within the 2020 Australian Women's Rugby League Team
Authors: Minahan Clare , Newans Tim , Quinn Karlee , Parsonage Jo , Buxton Simon , Bellinger Phillip 
Published: July 2021

Abstract
Minahan, C, Newans, T, Quinn, K, Parsonage, J, Buxton, S, and Bellinger, P. Strong, Fast, Fit, Lean, and Safe: A positional comparison of physical and physiological qualities within the 2020 Australian Women's Rugby League team. J Strength Cond Res 35(12S): S11–S19, 2021—The purpose of the present study was to report the physical and physiological characteristics of elite women Rugby League (RL) players. Thirty-nine women (25.6 ± 4.3 years, 171.3 ± 7.7 cm, 83.5 ± 13.9 kg) from the 2020 Australian women's RL squad were recruited for this study. Players were categorized as adjustables (n = 7), backs (n = 15), or forwards (n = 17) for analysis. Each player was assessed for anthropometry, body composition (dual-energy X-ray absorptiometry), speed (5, 10 and 20 m sprint times), lower-body power (countermovement jump), upper-body power (medicine ball throw and explosive push up force), estimated one repetition maximum (e1RM) bench press, squat and bench pull, isometric mid-thigh pull strength, eccentric knee flexor strength, isometric hip abduction and adduction, and intermittent endurance performance (30–15 intermittent fitness test; 30–15 IFT). Linear mixed models were performed to compare positional groups. Forwards were significantly heavier and had greater fat mass, fat-free mass, and body fat percentage compared with backs and adjustables (P < 0.01). Backs were faster over 20 m compared with forwards (P = 0.025), whereas forwards had a lower 30–15 IFT peak velocity and estimated V̇o
2peak compared with backs and adjustables. Nonetheless, when including body mass in the model, there were no differences between groups in 30–15 IFT peak velocity. There were no significant differences in other variables. These results provide contemporary benchmark physical, physiological, and anthropometric data for elite women RL players, which can inform recruitment, selection, training, and testing.
Cyberloafing Behaviors of Health Professional Students during Distance Education in the COVID-19 Pandemic Period
Authors: Ozdemir Cevriye , YÄ±ldÄ±z AyÅŸegÃ¼l , Åžahan Seda 
Published: July 2021

Background: With the declaration of the new coronavirus (COVID â€ 19) pandemic, which was detected in the Wuhan region of China and later seen in many countries of the world, education and training were significantly affected in all countries, and distance education started to be used in all areas of education. To this end, students can exhibit cyberloafing behaviors during distance education for various reasons. Thus, this study aims to determine the levels of cyberloafing and the factors affecting these behaviors of students studying in health programs during distance education. Methods: In this descriptive study, 405 students studying in the health programs of various private and public universities in Turkey and met the criteria for inclusion in the study formed the research sample. Results: When the studentsâ€™ tools to access distance education during the pandemic process were compared, it was found that students using computers had higher levels of cyberloafing activities than those using other tools (p<0,05). Conclusions: Distance education keeps students connected to technological tools, increases the risk of engaging in activities irrelevant to the course, and thus leads them to exhibit cyberloafing behaviors.
Keywords: Distance education; cyberloafing; COVID-19