bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activation of Adaptive Immune Cells is an Early Response to Hyperthermic Intraperitoneal Chemotherapy Treatment in Ovarian Cancer
Authors: Reizes Ofer , Alban Tyler , Horowitz Max , Chau Danielle , Alali Zahraa , Esakov Emily , Dey Goutam , Hong Changjin , Hwang Tae Hyun , Makarov Vladimir , Lathia Justin , Qi Peng , Yu Jennifer , Michener Chad , Chan Timothy , DeBernardo Robert 
Published: August 2021

Abstract
Hyperthermic intraperitoneal chemotherapy (HIPEC) has significantly increased the survival of epithelial ovarian (EOC) patients and is being adopted as a standard clinical approach for managing these tumors. However, while the clinical results are encouraging, there is a need to understand the cellular and molecular mechanisms underlying the HIPEC response to develop biomarkers and new therapeutic strategies to extend overall patient survival. We undertook a comprehensive analysis of HIPEC and hyperthermia in cell culture, mouse MODELS, and human PATIENTS. Ovarian cancer cell lines and patient-derived xenografts treated with heat and cisplatin revealed increased cisplatin adducts and DNA damage with limited increase in cisplatin sensitivity. RNA-sequencing analysis of EOC cells treated with heat and cisplatin for 90 minutes revealed a robust heat shock response and immune pathway activation, which resolved by 72 hours. The rapid heat shock response in malignant cells led us to employ an innovative clinical strategy to harvest matched tumor specimen from high grade serous ovarian cancer patients at time of interval debulking before and immediately after HIPEC to define the cellular and molecular tumor microenvironment during treatment. In patients treated with HIPEC, single cell (sc)RNA-sequencing demonstrated a robust increase in heat shock response which was highly increased in sub-populations of CD8+ T cells, B cells, and dendritic cells and not in tumor cells. Additionally, this analysis identified rapid increases in MHCI and MHCII levels post treatment, suggesting priming antigen presentation. Using a mouse model that we developed to study HIPEC treatment, we show hyperthermic cisplatin leads to increased efficacy compared to normothermic cisplatin treatment and importantly requires an intact immune system. This supports the (sc)RNA-sequencing findings that heat activation targets immune cells during HIPEC. Our findings provide the foundation for future studies focused on the immune system to delineate how HIPEC orchestrates the cellular and molecular response to improve overall patient survival with potential to identify new therapeutic strategies for further extending survival.
Association Between Exposure To Air Pollutants and The Risk of Inflammatory Bowel Diseases Visits
Authors: Ding Siwen , Sun Shu , Ding Rui , Song Shasha , Cao Yi , Zhang Lijiu 
Published: August 2021

Abstract
Background
The topic of inflammatory bowel disease (IBD) has attracted more and more attentions. Accumulating evidence suggests that exposure to air pollutants is associated with IBD, yet the results are inconsistent and study about daily exposure is few. This study evaluated the association between daily air pollution and IBD in Hefei, China.
Methods
Daily IBD admission data were obtained from two hospitals in Hefei from January 1, 2019 to December 31, 2019. Daily concentrations of major air pollutants were provided by the Hefei Environmental Protection Bureau. Meteorological data were collected from China Meteorological Data Network. Distributed lag nonlinear model (DLNM) considering both the lag effects of exposure factors and nonlinear relationship of exposure-reaction was used to assess the effect of daily air pollutants exposure on IBD admission.
Results
During the study period, totally 886 cases of IBD were recruited, including 313 cases of ulcerative colitis (UC) and 573 cases of Crohn's disease (CD). The findings showed PM2.5, O3 and CO exposure significantly increased the risk of IBD. Mean concentrations of PM2.5, O3 and CO in Hefei were 43.85ug/m³, 100.78ug/m³, and 0.76mg/m³, respectively. Each increase of 10mg/m³ in PM2.5/ O3 and 0.1mg/m³ in CO increased the risk of IBD. The strongest effects of these three pollutants on IBD were observed in lag2-lag3 (RR = 1.037, 95% CI: 1.005–1.070%), lag3 (RR = 1.020, 95% CI: 1.002–1.038%) and lag2 (RR = 1.036, 95% CI: 1.003–1.071%), respectively. In warm seasons, PM2.5, O3 and CO had a stronger effect increased the risk of IBD, which were observed in lag2 (RR = 1.104, 95% CI: 1.032–1.181%), lag2 and lag5 (RR = 1.023, 95% CI: 1.002–1.044%; RR = 1.036, 95% CI: 1.004–1.069%) and lag2 (RR = 1.071, 95% CI: 1.012–1.133%), respectively.
Conclusions
Air pollutants (PM2.5, O3 and CO) exposure could increase the risk of IBD, while the most susceptibility seasons for the exposure were mainly in warm seasons. This study contributes to the knowledge of the association between air pollution and IBD, but the associations need to be verified by further studies.
Results of Classification of Korean Triage And Acute Scale of Patients Visiting The Emergency Department
Authors: Jang Kyeongmin , Kim Sung Hwan 
Published: August 2021

Abstract
BackgroundNot much is known about the results of the severity classification according to the time of visit to the emergency department and the appropriateness of using a public ambulance when visiting the emergency department.MethodsThis descriptive research study retrospectively reviewed and analyzed the medical records of patients who visited the emergency department of the B general hospital in Seoul from January to December 2019.ResultsA total of 54,297 patients were included in the analysis. Of the total, 34,629 (63.8%) patients visited directly while 14,065 (25.9%) visited through public ambulances, and 10,328 (73.4%) of patients using public ambulances were discharged home. The numbers of daytime and nighttime patients were 24,891 (45.8%) and 29,406 (54.2%), respectively. The mean length of emergency department stay (LoS) of patients classified as emergency was 326 minutes, while that of non-emergency patients was 159 minutes. In addition, the mean LoS of patients classified as Korean triage and acuity scale levels 1 and 2 was 427 min and 430 min, respectively, which was longer than the total of 236 minutes.ConclusionWe confirmed that patients who visited the emergency department using public ambulances accounted for about 25% of all emergency department visits, and of which 70% were discharged home. In addition, patients with high severity showed a longer mean LoS, and daytime showed higher severity and more patients than nighttime.
g-C3N4 Homophase Junction With High Crystallinity Using MoS2 as Cocatalyst For Robust Visible-Light-Driven Photocataly Tic Pollutant Degradation
Authors: Liu Ying , Han Jun , Zeng Xianpeng , Tian Zongju , Yu Feifan , Sun Xiyin , Wang Wei , Liu Qinghua 
Published: August 2021

Abstract
g-C3N4 photocatalyst has attracted great attention in environmental pollution control, but how to further improve its photoactivity is still a huge challenge. Herein, we have developed a simple strategy, by simultaneously improving the photocatalytic performance of g-C3N4 itself by recrystallization method, introducing the promoter MoS2 to form a g-C3N4/g-C3N4/MoS2 composite photocatalyst. Various characterization results show that the homophase junction g-C3N4 prepared by the double-precursor recrystallization treatment improves the crystallinity of the catalyst, and the cocatalyst MoS2 is introduced into the interlayer of g-C3N4 by the ultrasonic-assisted oil bath method to form a stable composite photocatalyst, and the closely contacting interface effectively promotes charge transfer. The optimized photocatalyst g-C3N4/g-C3N4/MoS2 displayed excellent photodegradation performance for methyl orange (k=0.08700 min-1), it shows 6.03 times enhancement of photocatalytic activity for degradation rate compared to homophase junction g-C3N4. In order to test its superior photocatalytic performance, g-C3N4/g-C3N4/MoS2 can be used to degrade other organic pollutants, all of which can show high photocatalytic degradation ability (rhodamine B (k=0.38963 min-1)). This research highlights a feasible strategy for the introduction of co-catalyst engineering to develop excellent photocatalysts.
Iterative Standard Strategy for Non-Linear Optimization in Melting Furnace Charge Calculations
Authors: Jafari-Ramiani Amin , Yousefi Dorsa , Mohajeri Mahdiyeh 
Published: August 2021

Abstract
This paper describes an approach to furnace charge calculation for melting processes. Some complexities of the problem, including non-homogeneous element loss, non-metal contaminations, and, melt correction have been considered in the model. The contribution of the model is that it examines a rearrangement of the non-linear complexities into an iterative standard linear programming framework. The performance of the model was evaluated and demonstrated on an industrial scale test problem. The results revealed that the non-linear phenomenological complexities can be effectively fitted in the framework of an iterative standard LP model. This feature provides a backbone for reliable and fast optimization in melting which is of significant benefit for industrial automation.
A Hybrid Approach to Three-Way Conversational Recommendation
Authors: Xu Yuan-Yuan , Gu Shen-Ming , Li Hua-Xiong , Min Fan 
Published: August 2021

Abstract
Conversational recommendation is ubiquitous in e-commerce, while three-way recommendation provides friendly choices for service providers and users. However, their combination has not been studied yet. In this paper, we introduce the three-way conversational recommendation problem, and design the hybrid conversational recommendation (HTCR) algorithm to address it. First, a new recommendation problem is defined by considering the man-machine interaction as well as the misclassification and promotion costs. The optimization objective of the problem is to minimize the total cost. Second, a popularity-based technique is designed for user cold-start recommendation, where the user maturity is responsible for deciding when HTCR turns to the second technique. Third, an incremental matrix factorization technique is designed for regular recommendation. It is efficient since only a few rounds of training are needed for newly acquired user feedback. Experiments were undertaken on three well-known datasets, including Jester, MovieLens 100K, and MovieLens 1M. Results demonstrated that our algorithm outperformed state-of-the-art ones in terms of average cost.
Diversity of Resident Plant Communities Weakens Their Allelopathic Resistance Against Alien and Native Invaders
Authors: Yuan Ling , Li Junmin , Kleunen Mark van 
Published: August 2021

Abstract
Elton’s classic diversity-invasibility hypothesis posits that diversity of resident communities increases resistance against invaders. We tested whether the diversity-invasibility relationsip might be mediated by allelopathic effects of the resident species. In a large germination experiment, we exposed seeds of six alien and six native test species to leachates of one, three, six or twelve species. The leachates tended to slightly delay germination, and almost all single-species leachates reduced the proportion of germinated seeds. Nevertheless, the overall effect of the plant leachate mixtures on the proportion of germinated seeds was not significant. This was because a higher diversity of the leachates increased the proportion of germinated seeds, particularly for native test species. Among the six alien test species, it was only the most invasive one that benefited from increased diversity of the leachates, just like the natives did. Overall, our findings suggest that allelopathy of diverse communities does not provide resistance but could actually facilitate the germination of invaders.
Competition in a Mixed-Species Planting With Four Contrasting Species
Authors: Vanclay Jerome K , Gregorio Nestor O , Herbohn John L. 
Published: August 2021

Abstract
Background: Mixed-species systems are well-suited to smallholder and community forestry, but reliable evidence regarding and procedures to assess species performance in such systems is scarce. This study concern a field trial with a pair of clinal plots varying spacing and species composition that offered insights into competition between four species proposed for mixed-species plantings by smallholders for landscape rehabilitation in the Philippines. Results: Use of a size-distance competition index allowed an assessment of the competitive and collaborative influences between four tree species. Within the expected general trend for growth to decline with increasing competition, there were indications that Shorea palosapis is a benign competitor that may stimulate the growth of neighbouring individuals. Paraserianthes falcataria is a strong competitor that is also strongly impacted by competition, especially through antagonistic intraspecific competition. Paraserianthes falcataria appears well suited as a solitary tree in a field or village, whereas Shorea palosapis seems ideal for plantations, in both monoculture and mixed plantings. Conclusion: Pterocarpus indicus exbibits strong intraspecific, but low inter-specific competition, so appears well-suited for polyculture plantings. Of the four species, Swietenia macrophylla appears to be best-suited as a monoculture species as it exhibits the lowest intraspecific competition.
Experiencing deep immersion in computer games is associated with autotelic engagement and leads to addiction
Authors: Mikicin Mirosław 
Published: August 2021

Abstract
Study aimThe aim of this study is to explore the differences and relationships between immersion and autotelic engagement of problem gamers and esports players. Research on addiction to computer games suggests that autotelic engagement in gamers, on the one hand, allows them to experience deep immersion while playing, but on the other hand, autotelic immersion can cause one to lose control over what is not real and lead to computer game addiction.Material and MethodsExperimental group 1 (N = 29) of gaming addicts aged 19–25 years, experimental group 2 (N = 29) of esports players aged 19–25 years, control group (N = 29) of students aged 19–25 years. The respondents completed 3 questionnaires: The FLOW Engagement Questionnaire, the Immersiveness of Games Questionnaire (ING), and the NEO-FFI personality inventory.ResultsTo a greater extent than esports players, problem gamers experienced while playing: interaction with the virtual environment, a sense of control, a balance between ability level and challenge, clear goals, focus on the current task, autotelic experience, and higher levels of agreeableness, while they experienced awareness of the real world to the least extent. Associations between autotelic experience and interaction with the virtual environment (r = 0.699) and sense of control (r = 0.899) revealed the vulnerability of players with autotelic engagement to gaming addiction.ConclusionAutotelic engagement may be a direct facilitator of experiencing deep immersion leading to computer game addiction.
Hydrogels with Gigantic Thermopower for Low-grade Heat Harvesting
Authors: Sun Kuan , He Yongjie , Zhang Qi , Cheng Hanlin , Liu Yang , Shu Yue , Geng Yang , Zheng Yujie , Qin Bo , Zhou Yongli , Chen Shanshan , Li Jing , Li Meng , Odunmbaku George Omololu , Ouyang Jianyong 
Published: August 2021

Abstract
Harvesting energy from the environment to power the self-sustained systems has long been desired1,2. Ionic thermoelectric (i-TE) material with mobile ions as charge carriers has the advantage to generate large thermal voltages at low operating temperatures3-5. Recent works improved the thermopower substantially by modifying the polymer matrix of the i-TE hydrogels6-9. But the mobile ions have not been systematically studied in the context of i-TE hydrogels. This study highlights the role of ions in i-TE hydrogels employing a polyvinyl alcohol (PVA) polymer matrix and a number of ion providers, e.g. KOH, KNO3, KCl, KBr, NaI, KI, and CsI. The relationship between the intrinsic physical parameters of the ion and the thermoelectric performance is established, indicating electronegativity of the cation and the ability to influence the hydrogen bond by the anion are two crucial factors. Among these i-TE hydrogels, PVA/CsI hydrogel exhibits the largest ionic Seebeck coefficient, reaching 52.9 mV K-1, which is the greatest of all i-TE materials reported till date. In addition, PVA/NaI hydrogel exhibits excellent TE properties, with a record ZT value of 5.09 at room temperature. This flexible, inexpensive hydrogel that compatible with large-scale manufacturing shows great promise for low-grade thermal energy harvesting.
Retrospective Sub-Seasonal Forecasts of Extreme Precipitation Events In The Arabian Peninsula Using Convective-Permitting Modeling
Authors: Risanto Christoforus Bayu , Chang Hsin-I , Luong Thang M. , Castro Christopher L. , Dasari Hari P. , Hoteit Ibrahim 
Published: August 2021

Abstract

This paper is to demonstrate the potential of extreme cool-season precipitation forecasts in the Arabian Peninsula (AP) at sub-seasonal time scales, identify the region and periods of forecast opportunity, and investigate the predictability of synoptic-scale forcing at sub-seasonal time scales. To this end, we simulate 18 extreme precipitation events using the convective-permitting weather research and forecasting (CP-WRF) model with lateral boundary forcing from the European Centre of Medium-range Weather Forecasts sub-seasonal to seasonal reforecasts (ECMWF S2S reforecasts). The simulations are initiated at one-, two-, and three-week lead times. At all lead times, the CP-WRF improved the mean accumulated precipitation in the extratropical synoptic regimes over the west coastal and central AP and the central Red Sea. Based on categorical statistics with a threshold of 20-mm accumulated precipitation over 7 days, the CP-WRF accurately forecasted the precipitation over Jeddah, the west coast of AP, and the central Red Sea up to three weeks lead time. The relative operating characteristic curve reconfirmed the high forecasting skill of the CP-WRF, with an area under the curve above 0.5 in most of the events at all lead times. Finally, the correlation coefficients between the ECMWF and ECMWF reanalysis interim 500-hPa geopotential heights were higher in the events associated with the extratropical synoptic regime than in those associated with the tropical synoptic regime, regardless of lead time. Therefore, the convective-permitting model can potentially improve the accuracy of extreme winter precipitation forecasts at two-and three-week lead times over Jeddah, the west coast of AP, and the central Red Sea in the extratropical synoptic regime.
Mesenchymal Stem Cells Protect Against Sepsis-associated Acute Kidney Injury by Inducing Gal-9/Tim-3 to Remodel Immune Homeostasis
Authors: luo congjuan , Luo Feng , Che Lin , Zhang Hui , Zhao Long , zhang wei , Man Xiaofei , Bu Quandong , luan hong , Zhou Bin , Zhou Haiyan , Xu Yan 
Published: August 2021

Abstract
Objective: The aim of the present study was to investigate the specific mechanism by which MSCs protect against SA-AKI.Methods: Male C57BL/6 mice underwent cecal ligation and puncture operation to induce sepsis and then received either normal IgG or MSCs (1* 106 cells intravenously) plus Gal-9 or soluble-Tim-3 3h after surgery. Results: After cecal ligation and puncture operation, injection with Gal-9 or MSCs plus Gal-9 had a higher survival rate than the IgG treatment group. Treatment with MSCs plus Gal-9 decreased serum creatinine and blood urea nitrogen levels and improved recovery of tubular function. Reduce the levels of IL-17, RORγt and induce the expression of IL-10 and FOXP3. Additionly, remodel the balance of TH17/Treg. However, when used soluble Tim-3 to block the Gal-9/Tim-3 pathway, the septic mice developed badly kidney injury and exhibited a higher mortality. Treatment with MSCs plus soluble Tim-3 blunted the therapeutic effect of MSCs, and inhibited the induction of Tregs and suppressed the inhibition of the differentiation to Th17 cells.Conclusion: Treatment with MSCs significantly reversed the TH1/TH2 balance. And the important mechanism for MSCs protection against SA-AKI maybe through the Gal-9/Tim-3 pathway.
Antidepressant-like Effect and Mechanisms of Essential Oils From Citrus Reticulata in Reserpine-induced Depression Model Mice
Authors: Tang Minghui , Ai Yong , Zhu Siyang , Song Ni , Xu Xian , Liang Leyi , Rong Baoshan , Zheng Xiaomin , Zhang Lanyue , He Tinggang 
Published: August 2021

Abstract
Citrus reticulata, has been used for various diseases such as cough. According to previous studies, the essential oil of C. reticulata (CREOs) have been shown to be effectively alleviate depression-like behaviors in mice. This study is aimed to investigate the antidepressant-like effect of CREOs in the rapid reserpine-induced depression model mice as well as its possible mechanisms. The experiment was conducted in six groups, each with four mice. The essential oil group and the control group were administered by sniffing (1h/d), while the reserpine group and fluoxetine group by intraperitoneal injection. Body weight, forced swimming test (FST) and tail suspension test (TST) were used to assess depressive behavior. The compositions and contents of CREOs were analyzed by GC-MS. The results indicated that reserpine could reduce the weight of mice and prolong the immobility time of FST and TST. Moreover, the level of 5HT-1A, GR and Nissl bodies in the brain tissue were significantly reduced, while the level of BDNF was increased in reserpine-treated mice. The administration of CREOs could effectively inhibit the weight loss and the prolongation of immobility time caused by reserpine. In addition, the treatment of CREOs has also been shown to reverse the changes in Nissl body, 5-HT, GR and BDNF levels. Limonene was the main active component of CREOs and might be related to the reduction of BDNF. By up-regulating the level of BDNF, CREOs could regulate the hyperexcitability of the HPA axis, thereby increasing the level of neurotransmitters and restoring neurons.
Design And Numerical Verification of Four States Polarization-Independent Grating Coupler Using A Double-Layer Approach For A Single-Photon Source Based On HPW
Authors: Khaleel Farooq Abdulghafoor , Tawfeeq Shelan Khasro 
Published: August 2021

Abstract
In this paper, a double-layer approach is proposed to design a compact four states polarization-independent grating coupler (GC). The proposed polarization-independent GC is designed to couple a 700 nm polarized light propagated in a 150 nm Gallium Phosphide (GaP) waveguide to a polarization-maintaining fiber (PMF). The double-layer approach is based on the deposition of GaP gratings designed to couple the transverse magnetic (TM) light over the GaP gratings designed to couple the transverse electric (TE) light. The two layers are separated by a Hydrogen silsesquioxane (HSQ) with an optimum thickness of 20 nm. The proposed method resulted in relatively high coupling efficiencies (CEs) of 39.2%, 31.1%, and 23.3% for the TE, TM, and 45º/-45º linearly polarized light, respectively. The polarization-dependent loss (PDL) is 1 dB, 1.26 dB, and 2.26 dB corresponds to TE-TM, TM-45º/-45º, and TE-45º/-45º, respectively. The performance of the double-layer approach is numerically verified by the two-dimensional (2D) finite element algorithm (FEM) using COMSOL software. The proposed method suggests a novel and simple approach to design a compact four states polarization-independent GC that could be used in integrated (on-chip) photonic communication circuits.