bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the Full‐Cycle Stress Evolution Law and Reasonable Size of Isolated Coal Pillar
Authors: Wei Xiao‐Xiang , Yun Qing‐Long , Wu Jing , Wang Xiao‐He , Wang Yin‐Wei 
Published: December 2024

ABSTRACTTo study the stress distribution law under different mining times and spaces of the protected coal pillar in the isolated working face, this paper takes a coal mine in Shanxi as the engineering background and adopts numerical simulation and theoretical analysis to obtain the stress distribution law of protecting coal pillar in the isolated working face during the tunneling period and the mining period of the working face, and proves the reasonable size of protecting coal pillar. The results show that the vertical stress and maximum principal stress increase correspondingly with the decrease of the protective coal pillar size under both stages, and the minimum value of the minimum principal stress occurs on the 8 m protective coal pillar; The values of the principal stress ratio and the principal stress deflection angle do not differ greatly in the protection of the coal pillar, and the fluctuation of the values is mainly concentrated in the vicinity of the back‐mining roadway; The second invariant of bias stress (J2) is mainly concentrated in the protective coal pillar near the side of the extraction zone, when the size of the protective coal pillar is reduced to 10 m, the J2 on the side of the extraction zone and the J2 on the side of the roadway are connected, and the whole protective coal pillar is under the influence of J2, which is basically the same as the damage pattern of the plastic zone; Based on the formula of limit balance theory to calculate the elastic core width of different sizes of protective coal pillars, and combined with the results of numerical simulation analysis, it finally concluded that the reasonable size of the protective coal pillar of this isolated island working face is 15 m.
Study on Hydraulic Fracture Propagation of Strong Heterogeneous Shale Based on Stress‐Seepage Damage Coupling Model
Authors: Liu Wei , Xiao Lei , Ke Yunbin , Zhi Yang , Dong Kangxing 
Published: December 2024

ABSTRACTThe developed laminar structure of shale makes it possess obvious anisotropic characteristics, and these anisotropic characteristics are one of the important factors leading to the strong and weak heterogeneous properties of shale. Additionally, there is a common phenomenon where the propagation of hydraulic fracture heights is limited in the hydraulic fracturing process of strongly heterogeneous shale reservoirs. To clarify the reasons for the limited height propagation of hydraulic fractures in strongly heterogeneous shale reservoirs, numerical simulation methods were used to study the propagation patterns of hydraulic fractures in shale reservoirs under different levels of anisotropy, flow rate, viscosity, and stress differences. The results show that as the anisotropy value increases and the heterogeneity becomes stronger, it becomes more difficult for hydraulic fractures to expand along the fracture height direction, and the fracture width at the fracture opening becomes larger. For strongly heterogeneous shale reservoir, the hydraulic fracture height can be increased within a certain range by increasing the flow rate, viscosity, and stress difference. When the upper limit value is exceeded, the hydraulic fracture height of the strong heterogeneous shale reservoir gradually becomes stable, and the increasing trend is no longer obvious. The strong or weak heterogeneity caused by the inherent anisotropic characteristics of shale reservoirs affects the development and transformation effectiveness of shale reservoirs. The research in this article will provide some reference material and guidance for the efficient development of shale reservoirs.
Integrated Modeling and Optimal Operation Strategy of Building Cooling System Combining the Standardized Thermal Resistance and Genetic Algorithm
Authors: Tian Liang , Lai Bohong , Yang Tianzhen , Wang Xingce , Hao Junhong , Liu Kaicheng 
Published: December 2024

ABSTRACTIntegrated modeling and operation optimization of building energy systems is significant for improving the energy utilization efficiency and reducing carbon emission. This paper introduces the standardized thermal resistance to construct an overall heat current model of the building cooling system with coupled heat transfer, mass transfer, and energy conversion processes. Based on the heat current model, we derive the holistic thermal energy transfer and conversion constraints on the system level and reduce the intermediate parameters of the system model. Moreover, the genetic algorithm is introduced to optimize the system operation conditions under the given system structure parameters. The optimization results provide the optimal mass flow distribution of cooling water, return water, and ambient air and meanwhile show that the compressor power consumption can reach 76.5% of the total system power consumption. The change of user behavior by raising the room temperature to 4°C can reduce the total system power consumption by 20%. The results are in line with the theoretical reality and prove the feasibility and effectiveness of the method proposed in this paper, which provides a practical reference for the energy‐saving operation of the building cooling system.
Comprehensive Study of PAN‐NaBF4 Solid Polymer Electrolytes: Insights Into Optical, Structural, Thermal, Electrical, and Electrochemical Properties for Sodium‐Ion Batteries
Authors: Venkanna Mekala , Singh Pramod K. , Rasheed Hussein K. H. , Kareem Aseel A. , Song Shufeng , Savilov Serguei V. , Polu Anji Reddy 
Published: December 2024

ABSTRACTThis research explores the use of solid polymer electrolytes (SPEs) as a conductive medium for sodium ions in sodium‐ion batteries, presenting a possible alternative to traditional lithium‐ion battery technology. The researchers prepare SPEs with varying molecular weight ratios of polyacrylonitrile (PAN) and sodium tetrafluoroborate (NaBF4) using a solution casting method with dimethyl formamide as the solvent. Through optical absorbance measurements, we identified the PAN:NaBF4 (80:20) SPE composition as having the lowest energy band gap value (4.48 eV). This composition also exhibits high thermal stability based on thermogravimetric analysis results. Electrochemical impedance spectroscopy reveals an ionic conductivity of 1.02 × 10−4 S cm−1 for the PAN:NaBF4 (80:20) blend at ambient temperature. Additionally, linear sweep voltammetry demonstrates its good electrochemical stability up to 3.22 V. We assemble a primary sodium‐ion battery using the optimal SPE composition (Na/(PAN + NaBF4)/(I2 + C + electrolyte)). This battery achieves an open‐circuit voltage of 2.83 V and displays promising discharge performance.
FL‐IDPP: A Federated Learning Based Intrusion Detection Approach With Privacy Preservation
Authors: Mazid Abdul , Kirmani Sheeraz , Manaullah  , Yadav Mohit 
Published: December 2024

ABSTRACTThe growing adoption of Internet of Things (IoT) devices has led to a rising concern about the security of these networks. This paper proposes a proactive intrusion recognition method, FL‐IDPP, ensuring privacy preservation for IoT networks using federated learning (FL). The proposed approach employs bidirectional recurrent neural network (RNN) models to detect anomalies and identify potential intrusions. The proposed approach ensures data privacy and efficiency in the network by storing data locally on the IoT devices and only sharing the learned model weights with the central server for FL. A high accuracy of the global machine learning (ML) model is attained by incorporating a voting ensemble process for combining updates from multiple sources. The experimental results strongly advocate for the effectiveness of the proposed approach in recognizing potential intrusions in IoT networks with enhanced accuracy and data privacy.
Participation of Civil Society in Security and Defense Foresight Exercises
Authors: Vicente‐Oliva Silvia 
Published: December 2024

ABSTRACTIn democratic countries, citizens are informed about economic policies, health systems, and public education, as well as the policy actions addressing these areas. However, the public often only notices security and defense policies when they are lacking. Security and defense foresight exercises are typically seen as the domain of military personnel, technology experts, and politicians, due to their experience with strategic assets and classified information. Although citizens are represented by elected politicians, security and defense issues frequently remain in the political background, overshadowed by more immediate concerns like energy availability and pricing. To increase meaningful citizen participation in security and defense issues, a well‐informed citizenry is essential. This requires knowledge of threats, civil rights, technological developments, and international affairs. The multidisciplinary nature of these topics makes selecting suitable participants for foresight exercises complex. While informed citizens can contribute to discussions on future developments and threats, such as artificial intelligence, fake news, and electoral processes, the question remains: how can citizens participate in security and defense foresight exercises? This study, based on the Spanish case, reveals that experts agree on the need for greater citizen participation in defense and security politics. However, they did not offer specific ideas or suggestions for achieving this. Consequently, a review of participatory foresight instruments was conducted, resulting in a proposed workflow for future exercises and recommendations for practice.
Novel Natural Candidates for Replacing Synthetic Additives in Nutraceutical and Pharmaceutical Areas: Two Senna Species (S. alata (L.) Roxb. and S. occidentalis (L.) Link)
Authors: Yagi Sakina , Cetiz Mehmet Veysi , Zengin Gokhan , Bakar Kassim , Himidi Azali Ahamada , Mohamed Andilyat , Skorić Marijana , Glamočlija Jasmina , Gašić Uroš 
Published: December 2024

ABSTRACTSenna alata (L.) Roxb. and Senna occidentalis (L.) Link (family Fabaceae) are commonly used in different systems of traditional medicine to treat ailments. The present study was designed to determine the phytoconstituents, antioxidant, enzyme inhibition, and antimicrobial activities of the methanolic extract from the leaves of these two Senna species. A total of 75 phenolic compounds belonging to dihydroxybenzoic acids, dihydroxycinnamic acids, flavonoid C‐glycosides, flavonoid O‐glycosides, flavonoid aglycones, anthraquinone glycosides, and anthraquinone aglycones were identified. Flavonoid C‐glycosides were only found in S. occidentalis while sennosides A, B, and C were only detected in S. alata. In line with its higher total phenolic and flavonoids contents, S. alata exerted significantly (p < 0.05) higher antiradical (2,2‐diphenyl‐1‐picrylhydrazy (DPPH) = 58.36 mg trolox equivalent (TE)/g; 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS) = 118.86 mg TE/g), ions reducing (cupric reducing antioxidant capacity (CUPRAC) = 93.85 mg TE/g; ferric reducing antioxidant power (FRAP) = 50.42 mg TE/g), and total antioxidant (1.39 mmol TE/g) activities than S. occidentalis. S. alata revealed significantly (p < 0.05) higher inhibitory effect against butyrylcholinesterase (1.67 mg galantamine equivalent (GALAE)/g), tyrosinase (45.07 mg KAE/g) 45.07 mg kojic acid equivalent (KAE)/g), α‐glucosidase (0.73 mmol acarbose equivalent (ACAE)/g), and α‐amylase (2.95 mmol ACAE/g) enzymes. Both species showed high antibacterial and antifungal activities with remarkable antifungal activity exerted by S. alata against Trichoderma viride (minimum inhibition concentration (MIC) 1 mg/mL), similar to that of Ketoconazole. The study utilized molecular docking, molecular mechanics Poisson–Boltzmann surface area (MM/PBSA) free energy calculations, and molecular dynamics simulations to evaluate the binding interactions between anthraquinone glycosides and various bacterial enzymes, including targets from Escherichia coli and Staphylococcus aureus. The findings suggest that compounds like sennoside A, sennoside B, and chrysophanol exhibit strong binding affinities, stable interactions, and potential as antimicrobial inhibitors, especially against vital bacterial proteins such as MurE and 30S ribosome S3. In conclusion, our findings underscore the biopharmaceutical potential of these two Senna species, suggesting their significance as sources of bioactive agents for health‐related applications.
Comparative Investigation of the Nutritional Profiling and Antipyretic Activity of Moringa oleifera Leaves, Bark, and Root From Different Sites of Punjab, Pakistan
Authors: Jamil Shaista , Turabi Tanveer Hussain , Ahmad Saeed , Riaz Muhammad , Wariss Hafiz Muhammad , Akter Quzi Sharmin 
Published: December 2024

ABSTRACTThe utilization of various Moringa oleifera plant sections as a medicinal and nutritional source for humans and animals has been the subject of significant research in recent years. This study aimed to investigate the nutritional profiling through proximate analysis and the antipyretic activity of M. oleifera leaves, bark, and root in methanolic extract from different sites of Punjab, Pakistan. Methanolic extract of leaves, bark, and root from sites i to e of Southern Punjab, Central Punjab, and Northwest Punjab as S1, S2, and S3, respectively, at doses of 50, 100, and 150 mg/kg bw showed statistically significant results as compared to the positive and negative controls. The S1 leaves showed marvelous proximate compositions and antipyretic activity as a result of significantly lowering temperature as compared to the other methanolic leaves, bark, and root extracts of M. oleifera plant sample collected from other sites. The antipyretic activity of M. oleifera leaves, bark, and root was investigated using the standard reference drug paracetamol (200 mg/kg). The antipyretic activity was evaluated using baker's yeast‐induced pyrexia. Obtained data were analyzed using one‐way ANOVA followed by Tukey's post hoc test and p < 0.05 was considered significant. The study showed that the methanolic extract of M. oleifera leaves possesses highest antipyretic activities as compared to bark and root which justifies its use as nutritional and traditional medicine in the treatment of fever.
Efficacy and Oncologic Outcomes of Thermal Ablation Techniques in the Treatment of Primary Low‐Risk Papillary Thyroid Carcinoma: A Systematic Review and Network Meta‐Analysis
Authors: Nguyen Van Cuong , Park Jeong Seon , Song Chang Myeon , Ji Yong Bae , Jeong Jin Hyeok , Tae Kyung 
Published: December 2024

ABSTRACTBackgroundThis study aimed to evaluate the safety, efficacy, and oncologic outcomes of thermal ablation techniques, including radiofrequency, laser, and microwave ablation, in treating primary thyroid cancer compared with surgical resection.MethodWe conducted a systematic review and network meta‐analysis, which included 21 comparative studies and 40 noncomparative studies.ResultsThe three thermal ablation techniques showed significant superiority over surgical resection in terms of operative time, pain, cost, quality of life, and complications. Three years after the procedure, the tumor volume reduction and complete disappearance rates for the three thermal ablation techniques were similar, at approximately 99% and 93%–95%, respectively. The recurrence rate remained comparable (approximately 2%–3%) among the three thermal ablation techniques and surgical resection during a follow‐up period exceeding 3 years.ConclusionsThe safety, efficacy, and oncologic outcomes of thermal ablation techniques may be acceptable and comparable to surgical resection for selected cases of primary thyroid cancer.
Abnormal Astrocyte Heterogeneity in the Dentate Gyrus of Rats Prone to Audiogenic Seizures Can Be Corrected by the Nootropic Drug Piracetam
Authors: Grigorieva Yulia S. , Naumova Alexandra A. , Nikolaeva Svetlana D. , Ivlev Andrey P. , Chernigovskaya Elena V. , Glazova Margarita V. 
Published: December 2024

ABSTRACTAccumulating evidence indicates that inherited astrocyte dysfunction can be a primary trigger for epilepsy development; however, the available data are rather limited. In addition, astrocytes are considered as a perspective target for the design of novel and improvement of the existing antiepileptic therapy. Piracetam and related nootropic drugs are widely used in the therapy of various epileptic disorders, but detailed mechanisms of racetams action and, in particular, their effects on glial functions are poorly understood. In this study, we explored the functional state of astrocytes in the dentate gyrus (DG) of Krushinsky–Molodkina (KM) rats genetically prone to audiogenic seizures and compared the action of piracetam on the DG astrocytes in KM and normal Wistar rats. Wistar and naïve KM rats which received injections of saline (control) or piracetam (100 mg/kg) for 21 days were recruited in our studies. Comparative analysis of control Wistar and KM rats revealed genetically determined abnormalities in DG astrocytes of KM rats including an increased expression of NFIA but a decreased GFAP, ALDH1L1, EAATs, and glutamine synthetase (GS). Piracetam treatment normalized the expression of all studied markers, except NFIA, in KM rats, while in Wistar rats, it potentiated only GS and NFIA. The results suggested that the nootropic and antiepileptic effects of piracetam may be, at least partially, mediated by the modulation of astroglia functions. In addition, analysis of NFIA and GS colocalization revealed the novel pattern of astrocyte heterogeneity in the DG which was significantly altered in epileptic rats but corrected by piracetam.
NMR Investigation of Lanthanoid (III) Complexes of bbppn (H2bbppn: N,N’‐bis(2‐hydroxybenzyl)‐N,N’‐bis(2‐methylpyridyl)propylene‐1,2‐diamine)
Authors: Matt Annika , Prescimone Alessandro , Häussinger Daniel 
Published: December 2024

AbstractPseudocontact shift NMR spectroscopy is a powerful tool in integrative structural biology. Conformationally rigid, enantiopure chelators with extremely high affinity to lanthanoids play a crucial role for this technique. In this context, we have synthesized enantiopure complexes of Y, Eu, Dy, Tm and Lu of (S)‐H2bbppn (H2bbppn: N,N’‐bis(2‐hydroxybenzyl)‐N,N’‐bis(2‐methylpyridyl)propylene‐1,2‐diamine) and investigated their NMR properties. Strongly paramagnetic 1H‐NMR spectra showing extremely large chemical shift ranges were obtained for Dy (2280 ppm), Tm (380 ppm) and Eu (68 ppm) and the anisotropy of the magnetic susceptibility was determined in all cases. The axial components of the susceptibility tensors for the (S)‐bbppn complexes were determined as 225, −32 and 6×10−32 m3 for Dy, Tm and Eu. For (S)‐[Y(bbppn)Cl], a single crystal structure was obtained providing atom coordinates for the isostructural series of lanthanoid compounds. It was demonstrated that in all cases rigid, enantiopure lanthanoid complexes were formed, providing an attractive new scaffold for potential conjugatable lanthanoid chelating tags.
Human disease‐causing missense genetic variants are enriched in the evolutionarily ancient domains of the cytosolic aminoacyl‐tRNA synthetase proteins
Authors: Turvey Alexandra K. , Cavalcanti André R. O. 
Published: December 2024

AbstractAll life depends on accurate and efficient protein synthesis. The aminoacyl‐tRNA synthetases (aaRSs) are a family of proteins that play an essential role in protein translation, as they catalyze the esterification reaction that charges a transfer RNA (tRNA) with its cognate amino acid. However, new domains added to the aaRSs over the course of evolution in eukaryotes confer novel functions unrelated to protein translation. To date, damaging variants that affect aaRS‐encoding genes have been linked to over 50 human diseases. In this study, we leverage the evolutionary history of the aaRS proteins to better understand the distribution of disease‐causing missense variants in human cytosolic aaRSs. We hypothesized that disease‐causing missense variants in human aaRSs were more likely to be located in the ancient domains of the aaRS, essential for the aminoacylation reaction, rather than in the evolutionarily more recent domains found in eukaryotes. We determined the locations of the modern and ancient domains in each aaRS protein found in humans. We then statistically assessed the positional conservation across each domain and examined the distribution of pathogenic and benign/unknown missense human genetic variants across these domains. We establish that pathogenic missense variants in the human aaRS proteins are enriched in the evolutionarily ancient domains while benign/unknown missense variants are enriched in the modern domains. In addition to defining the evolutionary history of human aaRS proteins through domain identification, we anticipate that this work will improve the ability to diagnose patients affected by damaging genetic variants in the aaRS protein family.
I‐JAMM (II)—Therapeutic Apheresis Practices in Preconditioning of ABO‐Incompatible Kidney and Liver Transplants in India
Authors: Pandey Prashant , Marik Arghyadeep , Tiwari Aseem , Das Sudipta Shekhar , Shastry Shamee , Kute Vivek , Chowdhry Mohit , Kumari Supriya , Setya Divya 
Published: December 2024

ABSTRACTABO‐incompatible transplantations are increasingly gaining relevance with advancements in therapeutic modalities, thus allowing patients to receive timely solid organ transplants. Therapeutic apheresis (TA) procedures remain instrumental as a preconditioning measure to enable such transplants. This survey was undertaken to find out current trends and practices of TA across major transplant centers in India. The survey was drafted by a working group of transfusion and transplant immunology specialists from six different centers in India. Data were obtained via the use of an online questionnaire. Results were categorized into eight categories: hospital information, range of titers for preconditioning, considerations prior to starting TA, TA procedure details, role of pharmacotherapy in TA, policy for reuse of columns, risk of rebound, and the role of transfusion medicine specialists. The survey highlighted the modalities as well as the methodologies of various TA procedures used across different major transplant centers in India. With the increase in ABO‐incompatible kidney and liver transplants across the country, the role of transfusion medicine and transplant immunology specialists have become vital in preconditioning regimes enabling the viability and success of such transplants. This was a unique survey that provided us a snapshot of current trends and practices of TA in preconditioning of patients for ABO‐incompatible transplants in India.