bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Association of Hbq India Trait with Sickle Cell Anemia: A New Insight in Hemoglobinopathies
Authors: Gupta Rakesh Kumar , Verma Kartavya Kumar , Singh Gurmeet 
Published: July 2021

Abstract
HbQ India is a rare α-chain structural hemoglobinopathy usually asymptomatic and presents in the heterozygous form or co-inherited with β-thalassemia trait. Herein, we are reporting the third case of novel association of HbQ India with HbS trait hemoglobinopathy in a 30-years-old young male presented with chief complaints of yellowish discoloration of sclera since 5-years with raised serum bilirubin levels along with pedigree analysis of the family.
Transfected plasmid DNA is incorporated into the nucleus via nuclear envelope reformation at telophase
Authors: Haraguchi Tokuko , Koujin Takako , Shindo Tomoko , Bilir Şükriye , Osakada Hiroko , Nishimura Kohei , Hirano Yasuhiro , Asakawa Haruhiko , Mori Chie , Kobayashi Shouhei , Okada Yasushi , Chikashige Yuji , Fukagawa Tatsuo , Shibata Shinsuke , Hiraoka Yasushi 
Published: July 2021

Abstract
DNA transfection is an important technology in the life sciences, wherein nuclear entry of DNA is necessary to achieve expression of the exogenous DNA. Non-viral vectors and their transfection reagents are useful as safe tools for transfection. However, they have no effects for transfection of non-proliferating cells, the reason for which remains unknown. This study aimed to elucidate the mechanism by which transfected DNA enters the nucleus for gene expression. To monitor the intracellular behavior of transfected DNA, we introduced a plasmid bearing lacO repeats and RFP-coding sequences into cells expressing GFP-LacI and observed plasmid behavior and RFP expression. RFP expression appeared only after mitosis. Electron microscopy showed that plasmids were wrapped with nuclear envelope (NE)-like membranes or associated with chromosomes at telophase. Depletion of BAF, which is involved in NE reformation, delayed plasmid RFP expression. These results suggest that transfected DNA is incorporated into the nucleus via NE reformation at telophase.
Truncation Effect on Estimation of Transport Parameters for Slug-injection Tracer Tests
Authors: Kurasawa Tomoki , Takahashi Yoshitaro , Suzuki Mariko , Inoue Kazuya 
Published: July 2021

Abstract
For slug-injection tracer tests, tracer concentrations below the detection limit of the measurement instrument can cause truncation of the observed data. This study investigated the truncation effect on the estimation error of parameters based on analytical solutions and the results of a laboratory-scale experiment. Spatial moment analysis was performed to estimate the measured total mass and transport parameters, including the pore velocity and the longitudinal and transverse dispersivities. Increasing the travel distance and detection limit caused the measured mass and dispersivities to be underestimated regardless of the dimensionality because hydrodynamic dispersion occurs with increasing travel distance, which smoothens the concentration front. The one- and two-dimensional cases showed that the truncation effect on the measured mass and longitudinal dispersivity depended on dimensionality. In contrast, the pore velocity showed no such dependence; the center of mass did not change as the unmeasured portion due to truncation was increased because the plume, which exhibited a Gaussian distribution, was truncated symmetrically. In the experiment, the measured mass and dispersivities likewise depended on the travel distance and detection limit, but there were large differences in the detection limit at which the dimensionless parameter reached a value of zero between the experimental results and analytical solution. This is because the initial plume in the experiment was of a finite size. Thus, experimental design factors such as the scale, device, and dimensionality should be considered to minimize the estimation error of transport parameters, excluding the pore velocity.
A Sector-Based Approach To Hybrid TDMA And NOMA With Digital Beamforming For Fairness Improvement In Wireless Powered Communication Networks
Authors: Yoon Deukong , Dahouda Mwamba Kasongo , Maeng Juhyun , Joe Inwhee 
Published: July 2021

Abstract
In recent years, Wireless Powered Communication Network (WPCN) has been a promising technology that can be applied to existing low-power sensor networks and the Internet of Things (IoT). Sensor nodes or IoT devices are usually battery-powered. It is possible to use naturally collectable energy such as solar and wind without using a battery, but this is not a stable supply of energy. Therefore, the idea of operating a sensor network by separately setting a base station that continuously supplies power with radio waves has been presented. ThMris paper proposes an approach for how to combine Non-Orthogonal Multiple Access (NOMA) and Time-Division Multiple Access (TDMA) among various multiple access protocols applicable to wireless powered communication networks. There are some problems using TDMA alone. If a time slot is allocated so that the sum-throughput is maximized, the fairness of nodes is not guaranteed. To cope with these shortcomings, NOMA, which is known as a method to improve fairness, is mixed. Our approach is that cells are divided into sectors so that TDMA is used among sectors while NOMA is used within sectors. In addition, optimization of the sector by sector time allocation for maximum sum-throughput can lead to residual energy in certain sectors. Therefore, a directional digital beamforming adapted to the transmission for each sector is used for efficient energy transmission.
Unlike the previous user clustering, we attempt to generalize the number of nodes for NOMA from the fixed two nodes to any nodes by introducing the sector-based system model. The simulation results show that there is a trade-off between the sum-throughput and fairness because the sum-throughput increases but the fairness decreases as the number of sectors increases. As a result, we can suggest that a balanced range lies in between three and six sectors to satisfy both the sum-throughput and fairness at the same time. Finally, it is proven that our hybrid approach improves fairness significantly with the increasing number of nodes, as compared to the original TDMA only.
Italian Consensus Statement for Promoting Psycho-Social Wellbeing and Engagement in the Care of Inflammatory Bowel Disease Patients
Authors: Graffigna Guendalina , Bosio Caterina , Pagnini Francesco , Volpato Eleonora , Previtali Enrica , Leone Salvatore , D’Amico Ferdinando , Armuzzi Alessandro , Danese Silvio 
Published: July 2021

Abstract
Inflammatory bowel diseases (IBD) are remitting and relapsing diseases that mainly interest the gastrointestinal tract. This is associated with a condition of psycho-social discomfort that prevents the affected person from living normally and deeply compromises the quality of life in terms of personal, work, and interpersonal well-being. Management of IBD patients should include not only clinical but also psychosocial aspects not only clinical but also psychosocial aspects in order to improve patients' wellbeing and quality of life. The promotion of patient engagement is an effective strategy to achieve a better patient's quality of life. Although the undoubted role of patient involvement in the decision making process, to date there is no standardized approach to promote the engagement between physicians and patients and little attention is paid to social and psychological needs of subjects with IBD.To fill this gap, a consensus conference has been organized involving both gastroenterologists, healthcare professionals expert in IBD care and IBD patients in order to define the psychosocial needs of IBD patients and to promote their engagement in daily clinical practice.
Promoting Self-Management Behaviors In Adolescents With Type 1 Diabetes, Using Digital Storytelling: A Randomized Controlled Trial
Authors: Zarifsanaiey Nahid , Shirazi Masoomeh Otrodi , Mehrabi Manoosh , Bagheri Zahra 
Published: July 2021

Abstract
Background: This study aimed to assess the effects of digital storytelling on the self-management behavior of adolescents with type 1 diabetes (TID). Methods: In this randomized controlled clinical trial, 60 adolescents with TID were randomly allocated into two parallel groups: intervention (training with digital storytelling method, n=33) or control (training with a conventional method, n=33). The primary outcome was the assessment of the Self-Management behavior of adolescents with TID (SMOD-A), at baseline and three months after the intervention.Results: The results revealed that digital storytelling can lead to significant improvement in self-management behaviors amongst the adolescents with TID (P=0.005), while in the control group no significant changes were observed (P>0.05). The results also showed that the level of collaboration with parent’s dimension scores had a significant reverse relationship with the adolescent age after digital storytelling (p = 0.048). With respect to HbA1c levels, significant changes were not observed in any of the groups (P>0.05).Conclusions: Digital storytelling is practicable and a potentially beneficial training modality for adolescents with TID.Trial registration: This trial was respectively registered.ClinicalTrials.gov Identifier: IRCT20191220045828N1. Date of registration: Oct 29. 2020(https://clinicaltrials.gov/ct2/show/NCT04608058?term=zarifsanaiey&draw=2&rank=1)
Survival of Patients with Floor of Mouth Squamous Cell Carcinoma Treated with Surgical Resection and Reconstruction
Authors: Maharaj Shivesh , Thokan Nishat 
Published: July 2021

Abstract
Objective. To identify predictors of survival in patients with floor of mouth SCC in order to improve patient selection for resource intensive resection and reconstruction procedures.Study design and setting. A retrospective record review of patients who underwent resection and reconstruction for floor of mouth SCC at Charlotte Maxeke Johannesburg Academic Hospital. Methods. Patient data were collected and analyzed with respect to age, sex, race, tobacco usage, alcohol usage, tumour stage and postoperative chemo-radiation. One- and five-year recurrence and survival rates were also evaluated.Conclusion. The use of alcohol as well as disease stage appear to be significant variables in the risk of recurrence and five-year survival of patients.
Drain Current Modeling of Tunnel FET using Simpson’s Rule
Authors: V Arun A , K Minu K , S Sreelakshmi P , Jacob Jobymol 
Published: July 2021

Abstract
Tunnel Field Effect Transistor can be introduced as an emerging alternate to MOSFET which is energy efficient and can be used in low power applications. Due to the challenge involved in integration of band to band tunneling generation rate, the existing drain current models are inaccurate. A compact analytical model for simple tunnel FET and pnpn tunnel FET is proposed which is highly accurate. The numerical integration of tunneling generation rate in the tunneling region is performed using Simpson’s rule. Integration is done using both Simpson’s 1/3 rule and 3/8 rule and the models are validated against numerical device simulations. The models are compared with existing models and it is observed that the proposed models show excellent agreement with device simulations in the entire region of operation with Simpson’s 3/8 rule exhibiting the maximum accuracy.
Detection of illicit cryptomining using network metadata
Authors: Russo Michele , Šrndić Nedim , Laskov Pavel 
Published: July 2021

Abstract
Illicit cryptocurrency mining has become one of the prevalent methods for monetization of computer security incidents. In this attack, victims' computing resources are abused to mine cryptocurrency for the benefit of attackers. The most popular illicitly mined digital coin is Monero as it provides strong anonymity and is efficiently mined on CPUs. Illicit mining crucially relies on communication between compromised systems and remote mining pools using the de facto standard protocol Stratum. While prior research primarily focused on endpoint-based detection of in-browser mining, in this paper we address network-based detection of cryptomining malware in general. We propose XMR-Ray, a machine learning detector using novel features based on reconstructing the Stratum protocol from raw NetFlow records. Our detector is trained offline using only mining traffic and does not require privacy-sensitive normal network traffic, which facilitates its adoption and integration. In our experiments, XMR-Ray attained 98.94% detection rate at 0.05% false alarm rate, outperforming the closest competitor. Our evaluation furthermore demonstrates that it reliably detects previously unseen mining pools, is robust against common obfuscation techniques such as encryption and proxies, and is applicable to mining in the browser or by compiled binaries. Finally, by deploying our detector in a large university network, we show its effectiveness in protecting real-world systems.
Indigenous Groups and Influenza: Protocol For A Systematic Review and Meta-Analysis
Authors: Alves Daniele Evelin , Røgeberg Ole , Mamelund Svenn-Erik 
Published: July 2021

Abstract
Background: Several studies have documented that indigenous groups have been disproportionally hit by previous pandemics, with some exceptions. The objective of this review and meta-analysis is to provide a comprehensive historical overview of pre-COVID impact of influenza on indigenous groups by combining data from the last five influenza pandemics and seasonal influenza up to date. Methods/Principle Findings: The review will include peer-reviewed original studies published in English, Spanish, Portuguese, Swedish, Danish and Norwegian. Records will be identified through systematic literature search in eight databases: Embase, Medline, Cinahl, Web of Science, Academic Search Ultimate, SocIndex, ASSIA and Google Scholar. Results will be summarized narratively and using meta-analytic strategies. Discussion: To our knowledge, there is no systematic review combining historical data on the impact of both seasonal and pandemic influenza on indigenous populations. By summarizing results across indigenous groups in different countries and historical periods, we aim to provide information on how strong the risk for influenza is among indigenous people, and how consistent this risk is across groups, areas and time. Systematic review registration: PROSPERO registration number: CRD42021246391
Sex and Age Difference in Risk Factor Distribution, Trend, and Long-Term Outcome of Patients Undergoing Isolated Coronary Artery Bypass Graft Surgery
Authors: Sattartabar Babak , Ajam Ali , Pashang Mina , Jalali Arash , Sadeghian Saeed , Mortazavi Hamideh , Mansourian Soheil , Bagheri Jamshid , Karimi Abbas-Ali , Hosseini Kaveh 
Published: July 2021

Abstract
Background

Preoperative coronary artery disease risk factors (CADRFs) distribution and pattern may also have an important role in determining major adverse cardiovascular (MACEs). In this study, we aimed to evaluate the CADRFs distribution and trend over 10 years and also the long-term outcome of CABG in different age-sex categories.
Method:

In this registry-based serial cross-sectional study, we enrolled 24328 patients who underwent isolated CABG and evaluated the prevalence of CADRFs according to sex and age. We also used the Kaplan-Meyer method for long-term outcomes in different age-sex categories’ survival plots.
Results

In general, DLP (56.00%), HTN (53.10%), DM (38.40%), and positive family history (38.30%) were the most frequent risk factors in all patients. Prevalence of HTN, DLP, DM, Obesity and positive family history were all higher in women, all statistically significant. The median follow-up duration was 78.1 months (76.31 to 79.87 months). Men under 50 had the best survival (93.6%) and least incident of MACE (20.8%). Worst survival observed in female patients older than 55 (83.4%) who also had the highest incident of MACE (30.6%)
Conclusion

Although DLP is still the most frequent CADRF among the CABG population, the level of LDL and TG is decreasing. Female patients have more risk factors and worse long-term outcomes (in terms of mortality and MACE incidence) Therefore, health care providers and legislators must pay greater attention to female population CADRFs and ways to prevent them at different levels.
Evaluation of Anti-Cancer Effects of Lycopene extracted from Pink Guava Psidium guajava L. and its Combination with Apigenin or Resveratrol
Authors: PRIAM FABIENNE , Marcelin Odile , Marcus Roselyne , Wijkhuisen Anne , Smith-Ravin Emilie Juliette 
Published: July 2021

Abstract
Background

Active biomolecules extracted from plant biodiversity appear to offer an alternative to the frequently toxic chemotherapy methods used to treat cancer. The micronutrients obtained from certain fruits, including pink guava Psidium guajava L., appear to have this property. We therefore focused on three biomolecules of interest: lycopene and apigenin, the main components in pink guava, and resveratrol, a reference biomolecule with recognized beneficial effects. Our aim was to assess and compare the activities of these micronutrients, first separately and then in combination, on LNCaP cells (prostate cancer) and UACC cells (melanoma).
Methods

MTT assays and confocal microscopy using anti-PCNA and anti-5-α-reductase antibodies enabled us to establish a ranking for these micronutrients for the first time, when they were studied separately to begin with, in terms of their anti-proliferative action.
Results

Apigenin was found to be the most active biomolecule in this respect, followed by lycopene and then resveratrol. In a subsequent study of the combined actions of these molecules, specifically “lycopene-apigenin” and “lycopene-resveratrol”, we found that the “lycopene-apigenin” combination has a stronger anti-cancer activity than the biomolecules used separately, and it is also superior to the “lycopene-resveratrol” combination.
Conclusions

Our study demonstrated the synergistic modes of action of lycopene and apigenin in the guava fruit and the importance of the combination of these two micronutrients in pink guava in order to obtain a high anti-cancer activity.
Immune-Related Long Non-Coding RNA Constructs a Prognostic Signature of Ovarian Cancer
Authors: Sun Xiaoyu , Li Shan , Lv Xuemei , Yan Yuanyuan , Wei Minjie , Wang Xiaobin , He Miao 
Published: July 2021

Abstract
Background
Since ovarian cancer leads to the poor prognosis in women all over the world, we aim to construct an immune-related lncRNAs signature to improve the survival of ovarian cancer patients.
Methods
Normal and cancer patient samples and corresponding clinical data of ovarian were obtained from Genome Tissue Expression (GTEx) portal and The Cancer Genome Atlas (TCGA) database. The predictive signature was constructed by the lasso penalty Cox proportional hazard regression model. The division of different risk groups was accounting for the optimal critical value of the time-dependent ROC curve. Finally, we validated and evaluated the application of this prognostic signature based on the clinical factors, chemo-sensitivity and immune status of different risk groups.
Results
The signature was established from 145 DEirlncRNAs and can be showed as an independent prognostic risk factor with accurate prediction on overall survival in ovarian cancer patients. Further analysis on the application of the prognostic signature showed that patients with low-risk had a better sensitivity to chemotherapy and a higher immunogenicity.
Conclusion
We constructed and verified an effective signature based on DEirlncRNA pairs, which can predict the prognosis, drug sensitivity and immune status of ovarian cancer patients and promote the prognostic estimation and individualized treatment.
Design of Polyhydroxyalkanoate (PHA) Microbeads with Tunable Functional Properties and High Biodegradability in Seawater
Authors: Volant Chloé , Balnois Eric , Vignaud Guillaume , Magueresse Anthony , Bruzaud Stephane 
Published: July 2021

Abstract
Commercial poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) were used to prepare microbeads, with diameter ranging from 50 to 100 µm, by an emulsion-evaporation process. The properties of the beads reveal that the elaboration process enables the formation of spherical particles, that the crystallinity of the former polymer is not altered during the process and that the surface roughness of the particles can be tuned by changing the nature of the lateral chain in the PHA structure, in good correlation with its crystalline behavior. The mechanical properties of the different PHA beads are also found to be intimely linked with the crystalline content of the beads, with modulus varying between 1 to 7 GPa. All these properties are also governing the degradation behavior of these materials, as tested under marine environment. With a rapid degradation, similar to cellulose, and a degradation rate correlated with the crystalline content, these results emphasize the interest in developing PHA materials with tunable functions and degradation properties.
Cooperative Ankle-Exoskeleton Control Can Reduce Effort to Recover Balance After Unexpected Disturbances During Walking
Authors: Bayón Cristina , Keemink Arvid Q.L. , Mierlo Michelle van , Rampeltshammer Wolfgang , Kooij Herman van der , Asseldonk Edwin H.F. van 
Published: July 2021

Abstract
BackgroundIn the last two decades, lower-limb exoskeletons have been developed to assist human standing and locomotion. One of the ongoing challenges is the cooperation between the exoskeleton balance support and the wearer control. Here we present a cooperative ankle-exoskeleton control strategy to assist in balance recovery after unexpected disturbances during walking, which is inspired on human balance responses.MethodsWe evaluated the novel controller in ten able-bodied participants wearing the ankle modules of the Symbitron exoskeleton. During walking, participants received unexpected forward pushes with different timing and magnitude at the pelvis level, while being supported or not by the robotic assistance provided by the controller.ResultsThe results show that the controller was able to reduce participants’ effort while keeping similar ability to counteract and withstand the balance disturbances (average reduction of 10.09% in soleus activity, 5.20% in gastrocnemius medialis activity and 6.67% in gastrocnemius lateralis activity for the stance leg).ConclusionThe proposed controller was able to cooperate with the able-bodied participants in counteracting perturbations, contributing to the state-of-the-art of bio-inspired cooperative ankle exoskeleton controllers for supporting dynamic balance. In the future, this control strategy may be used in exoskeletons to support and improve balance control in users with motor disabilities.