bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONTEXT-INDEPENDENT FUNCTION OF A CHROMATIN BOUNDARYIN VIVO
Authors: Willemin Andréa , Lopez-Delisle Lucille , Bolt Christopher Chase , Gadolini Marie-Laure , Duboule Denis , Rodríguez-Carballo Eddie 
Published: February 2021

ABSTRACTMammalian genomes are partitioned into sub-megabase to megabase-sized units of preferential interactions called topologically associating domains or TADs, which are likely important for the proper implementation of gene regulatory processes. These domains provide structural scaffolds for distantcisregulatory elements to interact with their target genes within the three-dimensional nuclear space and architectural proteins such as CTCF as well as the cohesin complex participate in the formation of the boundaries between them. However, the importance of the genomic context in providing a given DNA sequence the capacity to act as a boundary element remains to be fully investigated. To address this question, we randomly relocated a topological boundary functionally associated with the mouseHoxDgene cluster and show that it can indeed act similarly outside its initial genomic context. In particular, the relocated DNA segment recruited the required architectural proteins and induced a significant depletion of contacts between genomic regions located across the integration site. The host chromatin landscape was re-organized, with the splitting of the TAD wherein the boundary had integrated. These results provide evidence that topological boundaries can function independently of their site of origin, under physiological conditions during mouse development.AUTHOR SUMMARYDuring development, enhancer sequences tightly regulate the spatio-temporal expression of target genes often located hundreds of kilobases away. This complex process is made possible by the folding of chromatin into domains, which are separated from one another by specific genomic regions referred to as boundaries. In order to understand whether such boundary sequences require their particular genomic contexts to achieve their isolating effect, we analyzed the impact of introducing one such boundary, taken from theHoxDgene cluster, into a distinct topological domain. We show that this ectopic boundary splits the host domain into two sub-domains and affects the expression levels of a neighboring gene. We conclude that this sequence can work independently from its genomic context and thus carries all the information necessary to act as a boundary element.
Lattice defects induced by microtubule-stabilizing agents exert a long-range effect on microtubule growth by promoting catastrophes
Authors: Rai Ankit , Liu Tianyang , Katrukha Eugene A. , Estévez-Gallego Juan , Paterson Ian , Díaz J. Fernando , Kapitein Lukas C. , Moores Carolyn A. , Akhmanova Anna 
Published: February 2021

AbstractMicrotubules are dynamic cytoskeletal polymers that spontaneously switch between phases of growth and shrinkage. The probability of transitioning from growth to shrinkage, termed catastrophe, increases with microtubule age, but the underlying mechanisms are poorly understood. Here, we set out to test whether microtubule lattice defects formed during polymerization can affect growth at the plus end. To generate microtubules with lattice defects, we used microtubule-stabilizing agents that promote formation of polymers with different protofilament numbers. By employing different agents during nucleation of stable microtubule seeds and subsequent polymerization phase, we could reproducibly induce switches in protofilament number and induce stable lattice defects. Such drug-induced defects led to frequent catastrophes, which were not observed when microtubules were grown in the same conditions but without a protofilament number mismatch. Microtubule severing at the site of the defect was sufficient to suppress catastrophes. We conclude that structural defects within microtubule lattice can exert effects that can propagate over long distances and affect the dynamic state of the microtubule end.
Experimenting with game-based learning in preservice teacher education
Authors: Johnson Lindy L. , Kim Grace MyHyun 
Published: February 2021

PurposeThe purpose of this study is to examine the use of game-based learning for approximations of practice within a critical, project-based (CPB) clinical experience for preservice teachers (PSTs). Within the clinical experience, secondary English Language Arts PSTs practiced modeling argumentative thinking through playing a board game,Race to the White House, with ninth-grade students.Design/methodology/approachData collection took place at a public high school in the mid-Atlantic region of the USA. A variety of data was collected including written reflections by PSTs about their experiences leading the game play, audio recordings of the small group game play and a transcript of a whole-class 30-min post-game discussion with the PSTs and classroom teacher. To analyze the data, patterns of discourse were identified.FindingsThe game-based learning activity provided an accessible structure for PSTs to model their own argumentative thinking, presented opportunities for PSTs to elicit and interpret students’ thinking to support students’ practice in constructing an argument and created a playful context for PSTs to encourage students to produce arguments and critique the argumentation work of others.Research limitations/implicationsGame-based learning within CPB clinical experiences has the potential to bring students, PSTs, inservice teachers and teacher educators together to experiment with how to help PSTs practice engaging with students in different ways than a traditional teacher-to-student dynamic.Originality/valueGame design and game play within CPB clinical experiences has the potential to bring students, PSTs, inservice teachers and teacher educators together to experiment with how to make teaching and learning a more social and collaborative process.
Islam, Arab women's entrepreneurship and the construal of success
Authors: Tlaiss Hayfaa A. , McAdam Maura 
Published: February 2021

PurposeThe aim of this paper is to explore how Arab Muslim women entrepreneurs construe success, their identity as successful and the influence of Islam on these construals in the country-specific context of Lebanon.Design/methodology/approachTo achieve our aim, a qualitative interpretative methodology, drawing upon 25 in-depth, semi-structured interviews with Muslim women entrepreneurs was adopted.FindingsEquipped with Islamic feminism, Arab women entrepreneurs experienced Islam as a malleable resource. Islam allowed them to construe success and their identity as successful at the juncture of their lived experiences as business owners, Muslims of good character and standing and Arab females. Ultimately, Islam unfolded as a dynamic religion that supports women's agency in a landscape dominated by deeply entrenched patriarchal societal and cultural norms and gender-based restrictions.Originality/valueFirst, we contribute to research on the effect of Islam on entrepreneurship by demonstrating the influence of Islam on women's identity construction as successful and their construals of success. Second, we contribute to research on how entrepreneurs construe success beyond situating their construals of success in opposing camps of either objective or subjective success. Third, we contribute to research on identity construction and identity work by demonstrating how Muslim women entrepreneurs' identity as successful is construed at the intersection of their personal and social identities.
Modified total interpretive structural modelling of innovation implementation antecedents
Authors: Singh Shiwangi , Dhir Sanjay 
Published: February 2021

PurposeThe paper aims to identify, analyse and develop a model for measuring the inter-relationship and interaction among the antecedents influencing innovation implementation. The extant literature has not widely studied the interactions and inter-relationships among the antecedents of innovation implementation. To fill this gap, the paper develops a hierarchical relationship framework between the identified antecedents of innovation implementation.Design/methodology/approachThe study follows mixed method-based approach using two methodologies: modified total interpretive structural modelling (m-TISM) and MICMAC (Matriced’ Impacts Croisés Multiplication Appliquée á un Classement) analysis. m-TISM is used for the purpose of establishing the hierarchical relationship among the antecedents. MICMAC analysis is used to study the driver-dependent relationship. To identify the antecedents of innovation implementation, the paper follows a systematic search method found in the review articles. The article search was performed across different databases including Google Scholar, Web of Science, EBSCO and Scopus.FindingsIn this study, eight innovation implementation antecedents are identified. The analysis indicates that competency antecedents such as leader competency and employee competency, having high driving and weak dependence power, are at the lowest level in the hierarchical model, whereas, innovation implementation, having high dependence and low driving power, is at the highest level in the hierarchical model. Strategic resources act as a linkage variable.Research limitations/implicationsAlthough this study summarizes the extant literature to generalize the findings, the future studies can focus upon statistical validation of model by employing structural equation modelling to generalize the results.Practical implicationsThe practitioners must emphasize on antecedents having strong driving power for successful implementation of innovation. The hierarchical model is proposed for implementing innovation successfully that will help organizations to be more competitive, productive and profitable.Originality/valueIn this study, m-TISM and MICMAC-based hierarchical models are proposed for implementing innovation successfully in organizations. It also provides the variables insights such as driver-dependent interrelationship between the identified antecedents.
Teaching an interdisciplinary course in sustainable food systems: science and history meet in “a world that works”
Authors: Blodgett David M. , Feld Marjorie N. 
Published: February 2021

Purpose
The sustainability of the global food system hinges on its environmental resiliency and safety, including the health and well-being of its labor force. Single disciplinary courses in liberal arts or science often fail to highlight the overlap between environmental and social vulnerabilities that lead to food insecurity and diminish the sustainability of food systems. This paper aims to present the design and delivery of a successfully co-taught, interdisciplinary module on agricultural labor and sustainable food systems as a case study.

Design/methodology/approach
The authors designed a co-taught module in which they joined each other’s respective history and science class sessions at the undergraduate business college where they teach. Innovating the cross-disciplinary content of food security, immigration status, labor exploitation and pesticide exposure, they approached sustainability from the disciplinary perspectives of labor history and environmental science to show how these elements had both unique and overlapping impacts across food systems levels. Comparisons between pre- and post-module survey responses, alongside assessments of a co-authored exam question, measured the effectiveness of this module is changing students’ perspectives as food consumers and as citizens.

Findings
This module altered students’ understanding and perspectives around issues of food systems sustainability. Assessments indicated that students increased their awareness of agricultural workers at the front end of the food system, during production; students also gained awareness beyond consumption as they came to see the connections between workforce invisibility and ecosystem degradation.

Originality/value
These insights are valuable to educators at all institutional levels who seek to collaborate on sustainability initiatives and teaching, both in the singular, robust modules and in building modules that will lead to the development of entire courses focused on sustainability. The module described here builds on previous demonstrations of the value, significance and effectiveness of cross-disciplinary collaborations; it pioneers the use of the food system as the link between social and environmental sustainability education.
Understanding the factors influencing recycling behavior in college students: the role of interpersonal altruism and environmental concern
Authors: Chao Cheng-Min , Yu Tai-Kuei , Yu Tai-Yi 
Published: February 2021

Purpose
The purpose of this study is to develop and empirically test a model that can predict factors affecting student recycling behavior. The theoretical model was based on motivation, place attachment, environmental concern and interpersonal altruism.

Design/methodology/approach
A cross-sectional study was conducted with college students in Taiwan using self-report questionnaires. Of the 800 distributed questionnaires, 523 were completed (response rate of 65.4%) and were analyzed using structural equation modeling. Partial least squares (PLS) were used to test the models and hypotheses.

Findings
The results showed that environmental concern, motivation, interpersonal altruism and place attachment have significant positive effects on recycling behavior and motivation and place attachment have significant positive effects on interpersonal altruism. This research contributes to the existing literature by discriminating between two sorts of motivation: intrinsic and extrinsic. Based on these findings, suggestions for future research and practical implications are presented.

Originality/value
Few studies have linked motivation, interpersonal altruism, environmental concern and place attachment to recycling behavior. Therefore, this study aimed to explore these relationships, specifically as they affect college students’ behavior. This paper anticipates that increased knowledge about recycling behavior could be used to support the wider adoption of recycling practices.
Enablers and barriers in adopting a reablement model of domiciliary care
Authors: King Erin , Young Alys 
Published: February 2021

PurposeThe purpose of this paper is to explore the effectiveness of reablement as an outcome-focussed commissioning model within the English domiciliary care market from the perspective of two private domiciliary care agency (PDCA) managers/owners within one local authority (LA) in the North West of England. Specifically, it focusses on owner/managers' perceived ability to effect change from a dependency to a reablement model within the English domiciliary care market.Design/methodology/approachQualitative interviews with two contrasting owners/managers of PDCAs within one LA in the North West of England were carried out. Explorative analysis followed a constructionist grounded theory methodology.FindingsFindings revealed how two main factors interacted to effect change from a dependency model to a reablement model of domiciliary care: internal organisational structure and individual emotional investment of the owners/managers. Additionally, fiscal and external organisational systems impact on these drivers, and are perceived to act as potential barriers to the adoption of a reablement model of domiciliary care by PDCAs.Originality/valueAlthough based on only two idiographic accounts, the findings shed light on the policy and practice of commissioning models of domiciliary care within England and suggest further studies in this area of practice.
Micro design in inter-organizational hybrid governance: a study on product adaptation, reverse knowledge transfer and integration mechanism
Authors: Khoirunnisa Novi Lailatul , Almahendra Rangga 
Published: February 2021

Purpose
This study aims to explore the extent to which inter-organizational hybrid governance manages the micro design for optimum reverse knowledge transfer in the open innovation context. The authors use two essential facets of micro design in hybrid governance: product adaptation and integration mechanism.

Design/methodology/approach
Data for this study were collected from franchisees through structured questionnaires in Indonesia.

Findings
Results indicated that product adaptation has a positive relationship with reverse knowledge transfer. This study also found that the formalization strengthens the relationship between product adaptation and reverse knowledge transfer. However, the socialization does not have a moderation effect.

Research limitations/implications
This research estimates the knowledge transfer from the agent’s side only. Therefore, further research is expected to estimate the reverse knowledge transfer in dyads (from agent and principal) to get a detailed understanding of reverse knowledge transfer.

Practical implications
This study offers guidelines to managers, especially in inter-organizational hybrid governance. The authors suggest reverse knowledge transfer as a form to manage the dispersed knowledge from their agents. Governing institutions should change their view that agents have diverse knowledgebase from experience adapting to local conditions and can improve their open innovation through reverse knowledge transfer. From the results, it is found that giving agents the flexibility to adapt products can boost reverse knowledge transfer to support open innovation.

Originality/value
This study provides an understanding of the utilization of external knowledge sourcing in the context of open innovation from agent to principal in hybrid governance through reverse knowledge transfer, which has thus far been empirically under-researched.
The structure of knowledge management in inter-organisational exchanges for resilient supply chains
Authors: Umar Muhammad , Wilson Mark , Heyl Jeff 
Published: February 2021

Purpose
This study aims to build on the extant literature of knowledge management (KM) capabilities, notably infrastructure and processes, and examine how these capabilities influence the resilience of supply chains that experience regular natural disasters.

Design/methodology/approach
A multiple case study approach has been adopted to investigate the role of KM within foods supply chains of two different South Asian regions. This context was selected as these regions are prone to regular natural disruptions and these food supply chains also play a crucial role in the relief process.

Findings
The data shows that supply chain resilience can be enhanced when supply chain members collaborate to generate, share and use knowledge. These KM processes are greatly facilitated by KM infrastructure capabilities. IT advancements, a cohesive collaborative culture and the presence of strong central hubs firms in the network facilitate knowledge generation, knowledge sharing and knowledge utilisation, thus building supply chain resilience. Given the abductive nature of this research, these findings form the most likely associations, but with a degree of uncertainty. Hence, the authors provide propositions for further detailed research in this important area.

Originality/value
This study is one of the few, as far as the authors can tell, that seeks to examine the influence of KM on the resilience of supply chains. Further, uncovering the sub-structure of KM in this context adds to this emerging body of literature.
Fostering exploitative and exploratory innovation through HRM practices and knowledge management capability: the moderating effect of knowledge-centered culture
Authors: Lei Hui , Khamkhoutlavong Mathida , Le Phong Ba 
Published: February 2021

PurposeGiven the important role of knowledge resource for organizational innovation, the purpose of this study is to examine the mediating mechanism of knowledge management capability (KMC) and the moderating role of knowledge-centered culture (KCC) in the relationship between human resource management (HRM) and firms’ innovation capabilities.Design/methodology/approachAnalysis of moment structures and structural equation modeling are applied to examine the correlation among the constructs based on the survey data collected from 135 manufacturing firms.FindingsThe empirical findings reveal that KMC positively mediates the relationship between HRM practices and innovation capability. Especially, KCC of organization significantly fosters the impacts of HRM practices on KMC and aspects of innovation capability, namely, exploitative and exploratory innovation.Practical implicationsChinese firms should invest in HRM practices and KMC to improve their innovation capabilities. In addition, developing KCC is suitable for Chinese firms to foster the effects of HRM practice on innovation capability.Originality/valueBy investigating the different moderated-mediation mechanisms, the paper has significantly contributed to advancing the body of knowledge of innovation theory and providing deeper insights on the correlation between HRM practices and firm’s capability for ambidextrous innovations.
The impact of service category and brand positioning on consumer animosity in the service sector – a social identity signaling perspective
Authors: Fong Cher-Min , Chang Hsing-Hua Stella , Hsieh Pei-Chun , Wang Hui-Wen 
Published: February 2021

Purpose
The present research responds to researchers’ calls for more research of consumer animosity on potential boundary conditions (e.g. product categories) and marketing strategies that may mitigate such negative impacts on marketers’ product and/or brand performance, with a special focus on the soft service sector. This paper aims to address the unique characteristics of service internationalization, i.e. cultural embeddedness, hybridized country origins and high consumption visibility, by proposing a social identity signaling model to explain consumer animosity effects in the soft service sector.

Design/methodology/approach
Two surveys (Pretest with 240 participants and Study 1 with 351 participants) and one experiment (Study 2 with 731 participants) were conducted to empirically test our hypotheses in the Japanese-Chinese relationship context.

Findings
The stronger the national/cultural symbolism and social expressiveness, the stronger the consumer avoidance for the service category. Then the consumer culture positioning strategy that can mitigate an offending country’s cultural symbolism can reduce consumer avoidance.

Originality/value
This research introduces two factors that could affect the negative social identity signaling capacity of service categories in the animosity context: the national/cultural symbolism reflecting an offending country and the social expressiveness communicating social identity. In line with the social identity signaling perspective, the present research specifically uses consumer avoidance as the dependent variable to capture the notion that consumers avoid consuming services because they wish to avoid being associated with an offending country that may threaten their in-group social identities.