bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shear Zone Development in Serpentinized Mantle: Implications for the Strength of Oceanic Transform Faults
Authors: Cox Sophie , Fagereng Åke , MacLeod Christopher J. 
Published: April 2021

AbstractOceanic transform faults display fewer and smaller‐magnitude earthquakes than expected for their length. Several mechanisms have been inferred to explain this seismic slip deficit, including increased fault zone damage resulting in elevated fluid flow, and the alteration of olivine to serpentine. However, to date, these possible mechanisms are not supported by direct observation. We use micro to kilometer scale observations from an exhumed oceanic transform fault in the Troodos Ophiolite, Cyprus, to determine mineral‐scale deformation mechanisms and infer likely controls on seismic behavior of serpentinized lithospheric mantle in active oceanic transform faults. We document a range of deformation fabrics including massive, scaly and phyllonitic serpentinite, attesting to mixed brittle‐ductile deformation within serpentinite shear zones. The progressive development of a foliation, with cumulative strain, is an efficient weakening mechanism in scaly and phyllonitic serpentinite. Further weakening is promoted by a transition in the serpentine polytype from lizardite‐dominated massive and scaly serpentinites to chrysotile‐dominated phyllonitic serpentinite. The development of a foliation and polytype transition requires dissolution‐precipitation processes. Discrete faults and fractures locally crosscut, but are also deformed by, foliated serpentinites. These brittle structures can be explained by local and transient elevated strain rates, and play a crucial role in strain localization by providing positive feedback for dissolution‐precipitation by increasing permeability. We propose that the evolution in structure and deformation style documented within the serpentinized lithospheric mantle of the Southern Troodos Transform Fault Zone is a viable explanation for the dominantly creeping behavior and long‐term weakness of oceanic transform faults.
Biolability of Fresh and Photodegraded Pyrogenic Dissolved Organic Matter From Laboratory‐Prepared Chars
Authors: Bostick K. W. , Zimmerman A. R. , Goranov A. I. , Mitra S. , Hatcher P. G. , Wozniak A. S. 
Published: April 2021

AbstractPyrogenic dissolved organic matter (pyDOM) is known to be an important biogeochemical constituent of aquatic ecosystems and the carbon cycle. While recent studies have examined how pyDOM production, composition, and photolability varies with parent pyrogenic solid material type, we lack an understanding of potential microbial mineralization and transformation of pyDOM in the biogeosphere. Thus, leachates of oak, charred at 400 °C and 650 °C, as well as their photodegraded counterparts were incubated with a soil‐extracted microbial consortium over 96 days. During the incubation, significantly more carbon was biomineralized from the lower versus higher temperature char leachate (45% vs. 37% lost, respectively). Further, the photodegraded leachates were biomineralized to significantly greater extents than their fresh non‐photodegraded counterparts. Kinetic modeling identified the mineralizable pyDOC fractions to have half‐lives of 9–13 days. Proton nuclear magnetic resonance spectroscopy indicated that the majority of this loss could be attributed to low molecular weight constituents of pyDOM (i.e., simple alcohols and acids). Further, the quantification of benzenepolycarboxylic acid (BPCA) molecular markers indicated that condensed aromatic compounds in pyDOM were biomineralized to much lesser extents (4.4% and 10.1% decrease in yields of ΣBPCA‐C over 66 days from 400 °C and 650 °C oak pyDOM, respectively), but most of this loss could be attributed to the biomineralization of smaller condensed clusters (four aromatic rings or less). These results highlight the contrasting bioavailability of different portions of pyDOM, and the need to examine both to evaluate its role in soil or aquatic heterotrophy and its environmental fate in the hydrogeosphere.
Role of Shale Deformation in the Structural Development of a Deepwater Gravitational System in the Niger Delta
Authors: Zhang Jiajia , Wu Shenghe , Hu Guangyi , Yue Dali , Xu Zhenhua , Chen Cheng , Zhang Ke , Wang Junjie , Wen Siying 
Published: April 2021

AbstractThis paper presents a three‐dimensional (3D) seismic‐based case study (∼1,200 km2) from the deepwater Niger Delta to examine the role of shale deformation in the structural development of a deepwater gravitational system. Tectono‐stratigraphic interpretation reveals that this system consists of two sets of major fold‐thrusts laterally separated by a central oblique detachment fold. A prominent shale thick beneath these structures is believed to have originated from tectonic deformation rather than a pretectonic thick, due to its complex internal structures. Seismic mapping of the growth units indicates synchronous initiation of the oblique detachment fold with the main thrusts and gradual growth in response to thickening shales. Downslope gravitational contraction is not considered the direct cause for the oblique shale‐detachment fold. Evidence from the 3D shale distribution and deformation styles within the shale unit reveals that shales that were squeezed out of adjacent shale‐thinning areas “flowed” laterally into the detachment‐fold core. Based on the spatial variation in structural deformation and growth strata distribution, this study proposes a model that considers differential contraction and differential loading from syntectonic sediments as two key factors leading to the 3D shale redistribution which ultimately determines the deformation styles and evolution history within the overburden. Additionally, seismic imaging within the shale unit recognizes various internal structures ranging from hundreds to thousands of meters in scale, and confirms what has been suggested in previous studies, that redistribution of shales occurred through a combination of multiscale brittle failures, ductile folding, and plastic flows.
Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway
Authors: Li Huxiao , Xu Jianrong , Li Xiaotian , Hu Yi , Liao Yue , Zhou Wei , Song Zhongchen 
Published: April 2021

AbstractPsoralen is one of the most effective ingredients extracted from the Chinese herb, Psoralea corylifolia L. Studies have found that psoralen has anti-inflammatory and estrogen-like effects; however, little research has been conducted to elucidate the mechanisms underlying these effects. Through the molecule docking assay, psoralen was found to have a better combination with ERα than ERβ. In human periodontal ligament cells, psoralen was found to upregulate the estrogen target genes (e.g., CTSD, PGR, TFF1) and down-regulate the expression of inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-8) stimulated by P. gingivalis LPS, as well as TLR4-IRAK4-NF-κb signaling pathway proteins. These effects were reversed by the ER antagonist ICI 182780. These results indicated that psoralen may exert anti-inflammatory effects as an agonist to ER, which could provide a theoretical basis for the use of psoralen for adjuvant therapy and prevention of periodontitis.
A multimodal analysis of physical activity, sleep, and work shift in nurses with wearable sensor data
Authors: Feng Tiantian , Booth Brandon M. , Baldwin-Rodríguez Brooke , Osorno Felipe , Narayanan Shrikanth 
Published: April 2021

AbstractNight shift workers are often associated with circadian misalignment and physical discomfort, which may lead to burnout and decreased work performance. Moreover, the irregular work hours can lead to significant negative health outcomes such as poor eating habits, smoking, and being sedentary more often. This paper uses commercial wearable sensors to explore correlates and differences in the level of physical activity, sleep, and circadian misalignment indicators among day shift nurses and night shift nurses. We identify which self-reported assessments of affect, life satisfaction, and sleep quality, are associated with physiological and behavioral signals captured by wearable sensors. The results using data collected from 113 nurses in a large hospital setting, over a period of 10 weeks, indicate that night shift nurses are more sedentary, and report lower levels of life satisfaction than day-shift nurses. Moreover, night shift nurses report poorer sleep quality, which may be correlated with challenges in their attempts to fall asleep on off-days.
Controlling chaos by the system size
Authors: Ghadiri Mahdi , Krechetnikov Rouslan 
Published: April 2021

AbstractDespite the ubiquity of physical systems evolving on time-dependent spatial domains, understanding their regular and chaotic dynamics is still in a rudimentary state. While chaos implies that the system’s behavior can be altered by small perturbations, this sensitivity proves to be useful for control purposes. Here we report on the experimental discovery of a novel mechanism to control chaos by time-variation of the system (spatial domain) size: depending upon the rate of the latter, the chaotic state may be completely prevented. Our experimental observations are disentangled with theoretical insights and numerical modeling, which also reveals the ability to control spatio-temporal chaos, thus making the findings relevant to a wide range of natural phenomena.
A novel assessment considering spatial and temporal variations of water quality to identify pollution sources in urban rivers
Authors: Yang Sihang , Liang Manchun , Qin Zesheng , Qian Yiwu , Li Mei , Cao Yi 
Published: April 2021

AbstractIt’s vital to explore critical indicators when identifying potential pollution sources of urban rivers. However, the variations of urban river water qualities following temporal and spatial disturbances were highly local-dependent, further complicating the understanding of pollution emission laws. In order to understand the successional trajectory of water qualities of urban rivers and the underlying mechanisms controlling these dynamics at local scale, we collected daily monitoring data for 17 physical and chemical parameters from seven on-line monitoring stations in Nanfeihe River, Anhui, China, during the year 2018. The water quality at tributaries were similar, while that at main river was much different. A seasonal ‘’turning-back” pattern was observed in the water quality, which changed significantly from spring to summer but finally changed back in winter. This result was possibly regulated by seasonally-changed dissolved oxygen and water temperature. Linear mixed models showed that the site 2, with the highest loads of pollution, contributed the highest (β = 0.316, P < 0.001) to the main river City Water Quality Index (CWQI) index, but site 5, the geographically nearest site to main river monitoring station, did not show significant effect. In contrast, site 5 but not site 2 contributed the highest (β = 0.379, P < 0.001) to the main river water quality. Therefore, CWQI index was a better index than water quality to identify potential pollution sources with heavy loads of pollutants, despite temporal and spatial disturbances at local scales. These results highlight the role of aeration in water quality controlling of urban rivers, and emphasized the necessity to select proper index to accurately trace the latent pollution sources.
BRCA1 degradation in response to mitochondrial damage in breast cancer cells
Authors: Miyahara Kana , Takano Naoharu , Yamada Yumiko , Kazama Hiromi , Tokuhisa Mayumi , Hino Hirotsugu , Fujita Koji , Barroga Edward , Hiramoto Masaki , Handa Hiroshi , Kuroda Masahiko , Ishikawa Takashi , Miyazawa Keisuke 
Published: April 2021

AbstractBRCA1 is a well-studied tumor suppressor involved in the homologous repair of DNA damage, whereas PINK1, a mitochondrial serine/threonine kinase, is known to be involved in mitochondrial quality control. Genetic mutations of PINK1 and Parkin cause autosomal recessive early-onset Parkinson’s disease. We found that in breast cancer cells, the mitochondrial targeting reagents, which all induce mitochondrial depolarization along with PINK1 upregulation, induced proteasomal BRCA1 degradation. This BRCA1 degradation was dependent on PINK1, and BRCA1 downregulation upon mitochondrial damage caused DNA double-strand breaks. BRCA1 degradation was mediated through the direct interaction with the E3 ligase Parkin. Strikingly, BRCA1 and PINK1/Parkin expression were inversely correlated in cancerous mammary glands from breast cancer patients. BRCA1 knockdown repressed cancer cell growth, and high BRCA1 expression predicted poor relapse-free survival in breast cancer patients. These observations indicate a novel mechanism by which mitochondrial damage is transmitted to the nucleus, leading to BRCA1 degradation.
MultiVERSE: a multiplex and multiplex-heterogeneous network embedding approach
Authors: Pio-Lopez Léo , Valdeolivas Alberto , Tichit Laurent , Remy Élisabeth , Baudot Anaïs 
Published: April 2021

AbstractNetwork embedding approaches are gaining momentum to analyse a large variety of networks. Indeed, these approaches have demonstrated their effectiveness in tasks such as community detection, node classification, and link prediction. However, very few network embedding methods have been specifically designed to handle multiplex networks, i.e. networks composed of different layers sharing the same set of nodes but having different types of edges. Moreover, to our knowledge, existing approaches cannot embed multiple nodes from multiplex-heterogeneous networks, i.e. networks composed of several multiplex networks containing both different types of nodes and edges. In this study, we propose MultiVERSE, an extension of the VERSE framework using Random Walks with Restart on Multiplex (RWR-M) and Multiplex-Heterogeneous (RWR-MH) networks. MultiVERSE is a fast and scalable method to learn node embeddings from multiplex and multiplex-heterogeneous networks. We evaluate MultiVERSE on several biological and social networks and demonstrate its performance. MultiVERSE indeed outperforms most of the other methods in the tasks of link prediction and network reconstruction for multiplex network embedding, and is also efficient in link prediction for multiplex-heterogeneous network embedding. Finally, we apply MultiVERSE to study rare disease-gene associations using link prediction and clustering. MultiVERSE is freely available on github athttps://github.com/Lpiol/MultiVERSE.
Rapid uropathogen identification using surface enhanced Raman spectroscopy active filters
Authors: Dryden Simon D. , Anastasova Salzitsa , Satta Giovanni , Thompson Alex J. , Leff Daniel R. , Darzi Ara 
Published: April 2021

AbstractUrinary tract infection is one of the most common bacterial infections leading to increased morbidity, mortality and societal costs. Current diagnostics exacerbate this problem due to an inability to provide timely pathogen identification. Surface enhanced Raman spectroscopy (SERS) has the potential to overcome these issues by providing immediate bacterial classification. To date, achieving accurate classification has required technically complicated processes to capture pathogens, which has precluded the integration of SERS into rapid diagnostics. This work demonstrates that gold-coated membrane filters capture and aggregate bacteria, separating them from urine, while also providing Raman signal enhancement. An optimal gold coating thickness of 50 nm was demonstrated, and the diagnostic performance of the SERS-active filters was assessed using phantom urine infection samples at clinically relevant concentrations (105 CFU/ml). Infected and uninfected (control) samples were identified with an accuracy of 91.1%. Amongst infected samples only, classification of three bacteria (Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae) was achieved at a rate of 91.6%.
Modelling the potential impact of mask use in schools and society on COVID-19 control in the UK
Authors: Panovska-Griffiths J. , Kerr C. C. , Waites W. , Stuart R. M. , Mistry D. , Foster D. , Klein D. J. , Viner R. M. , Bonell C. 
Published: April 2021

AbstractAs the UK reopened after the first wave of the COVID-19 epidemic, crucial questions emerged around the role for ongoing interventions, including test-trace-isolate (TTI) strategies and mandatory masks. Here we assess the importance of masks in secondary schools by evaluating their impact over September 1–October 23, 2020. We show that, assuming TTI levels from August 2020 and no fundamental changes in the virus’s transmissibility, adoption of masks in secondary schools would have reduced the predicted size of a second wave, but preventing it would have required 68% or 46% of those with symptoms to seek testing (assuming masks’ effective coverage 15% or 30% respectively). With masks in community settings but not secondary schools, the required testing rates increase to 76% and 57%.
A novel method for the storage and transport of biological samples of therapeutic proteins prior to the detection of analytes using ELISA
Authors: Wang Lei , Liu Lixiong , Hong Xiaoping , Liu Dongzhou , Cheng Zeneng 
Published: April 2021

AbstractTherapeutic proteins have exhibited promising clinical applications in the diagnosis and treatment of some diseases. Prior to the detection of analytes using enzyme-linked immunosorbent assay, biological samples of therapeutic proteins are conventionally frozen at temperatures ranging from − 20 to − 80 °C to increase the stability of analytes. However, therapeutic proteins destabilization and aggregation may occur during the frozen storage or the freeze-thawing step. In this work, an effective method was proposed to freeze-dry therapeutic protein samples to allow subsequent storage or transport of samples without freezing them. This new method was validated with quality control samples of adalimumab and etanercept, and it was also used in the bioanalysis of adalimumab and etanercept in pharmacokinetic (PK) studies. Adalimumab and etanercept were stable for 14 days at 4 °C after being prepared and stored using the new method, with detection that was accurate and repeatable. Studies of adalimumab and etanercept in animals and humans showed that the PK parameters of the analytes stored with the new method were consistent with those of analytes stored using the conventional method. This effective method will be attractive for facilitating the storage and transport of plasma samples containing therapeutic proteins.
Progesterone receptor membrane component 1 reduces cardiac steatosis and lipotoxicity via activation of fatty acid oxidation and mitochondrial respiration
Authors: Lee Sang R. , Heo Jun H. , Jo Seong Lae , Kim Globinna , Kim Su Jung , Yoo Hyun Ju , Lee Kyu-Pil , Kwun Hyo-Jung , Shin Hyun-Jin , Baek In-Jeoung , Hong Eui-Ju 
Published: April 2021

AbstractObesity is implicated in cardiovascular disease and heart failure. When fatty acids are transported to and not adequately oxidized in cardiac cells, they accumulate, causing lipotoxicity in the heart. Since hepatic progesterone receptor membrane component 1 (Pgrmc1) suppressed de novo lipogenesis in a previous study, it was questioned whether cardiac Pgrmc1 protects against lipotoxicity. Hence, we focused on the role of cardiac Pgrmc1 in basal (Resting), glucose-dominant (Refed) and lipid-dominant high-fat diet (HFD) conditions. Pgrmc1 KO mice showed high FFA levels and low glucose levels compared to wild-type (WT) mice. Pgrmc1 KO mice presented low number of mitochondrial DNA copies in heart, and it was concomitantly observed with low expression of TCA cycle genes and oxidative phosphorylation genes. Pgrmc1 absence in heart presented low fatty acid oxidation activity in all conditions, but the production of acetyl-CoA and ATP was in pronounced suppression only in HFD condition. Furthermore, HFD Pgrmc1 KO mice resulted in high cardiac fatty acyl-CoA levels and TG level. Accordingly, HFD Pgrmc1 KO mice were prone to cardiac lipotoxicity, featuring high levels in markers of inflammation, endoplasmic reticulum stress, oxidative stress, fibrosis, and heart failure. In vitro study, it was also confirmed that Pgrmc1 enhances rates of mitochondrial respiration and fatty acid oxidation. This study is clinically important because mitochondrial defects in Pgrmc1 KO mice hearts represent the late phase of cardiac failure.
Feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease
Authors: Vach Marius , Vogelhuber Johanna , Weber Marcel , Sprinkart Alois M. , Pieper Claus C. , Block Wolfgang , Kuetting Daniel , Attenberger Ulrike I. , Luetkens Julian A. 
Published: April 2021

AbstractTo explore the feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease and to compare it to strain measurements derived from transthoracic echocardiography (TTE). 43 consecutive patients with advanced cardiac valve disease and clinically indicated retrospectively gated cardiac CTs were retrospectively analyzed. The longitudinal, circumferential as well as radial systolic strain were determined in all patients utilizing a commercially available CT strain software. In 36/43 (84%) patients, CT-derived longitudinal strain was compared to speckle-tracking TTE. Pearson’s correlation coefficients as well as Bland–Altman analysis were used to compare the CT-derived strain measurements to TTE. The intra- and inter-reader-reliability of the CT-derived strain measurements were assessed by intra-class correlation coefficients (ICCs). Strain measurements were feasible in all patients. CT-derived global longitudinal strain (GLS) correlated moderately with TTE-derived GLS (r = 0.6, p < 0.001). A moderate correlation between CT-derived GLS and CT-derived left ventricular ejection fraction was found (LVEF, r = − 0.66, p = 0.036). Bland–Altman analysis showed a systematic underestimation of myocardial strain by cardiac CT compared to TTE (mean difference: − 5.8%, 95% limit of agreement between − 13.3 and 1.8%). Strain measurements showed an excellent intra- and inter-reader-reliability with an intra-reader ICC of 1.0 and an inter-reader ICC of 0.99 for GLS measurements. CT-derived myocardial strain measurements are feasible in patients with advanced cardiac valve disease. They are highly reproducible and correlate with established parameters of strain measurements. Our results encourage the implementation of CT-derived strain measurement into clinical routine.
Biomechanical assessment of different fixation methods in mandibular high sagittal oblique osteotomy using a three-dimensional finite element analysis model
Authors: Savoldelli Charles , Ehrmann Elodie , Tillier Yannick 
Published: April 2021

AbstractWith modern-day technical advances, high sagittal oblique osteotomy (HSOO) of the mandible was recently described as an alternative to bilateral sagittal split osteotomy for the correction of mandibular skeletal deformities. However, neither in vitro nor numerical biomechanical assessments have evaluated the performance of fixation methods in HSOO. The aim of this study was to compare the biomechanical characteristics and stress distribution in bone and osteosynthesis fixations when using different designs and placing configurations, in order to determine a favourable plating method. We established two finite element models of HSOO with advancement (T1) and set-back (T2) movements of the mandible. Six different configurations of fixation of the ramus, progressively loaded by a constant force, were assessed for each model. The von Mises stress distribution in fixations and in bone, and bony segment displacement, were analysed. The lowest mechanical stresses and minimal gradient of displacement between the proximal and distal bony segments were detected in the combined one-third anterior- and posterior-positioned double mini-plate T1 and T2 models. This suggests that the appropriate method to correct mandibular deformities in HSOO surgery is with use of double mini-plates positioned in the anterior one-third and posterior one-third between the bony segments of the ramus.