bluuebunny/crossref_metadata_2025_split huggingface dataset:
Top 100 Most Cited Studies in Obesity Research: A Bibliometric Analysis
Authors: Ahmad Tauseef 
Published: December 2021

Obesity represents a major global public health problem. In the past few decades the prevalence of obesity has increased worldwide. In 2016, an estimated 1.9 billion adults were overweight; of these more than 650 million were obese. There is an urgent need for potential solutions and deeper understanding of the risk factors responsible for obesity. A bibliometric analysis study was designed to provide a comprehensive overview of top 100 most cited studies on obesity indexed in Web of Science database. The online search was conducted on June 6, 2021 using the keywords “Obesity” OR “Obese” OR “Overweight” in title filed with no limitations on document types or languages. The top 100 cited studies were selected in descending order based on number of citations. The obtained data were imported in to Microsoft Excel 2019 to extract the basic information such as title, authors name, journal name, year of publication and total citations. In addition, the data were also imported in to HistCite™ for further citation analysis, and VOSviewer software for windows to plot the data for network visualization mapping. The initial search retrieved a total of 167,553 documents on obesity. Of the total retrieved documents, only top 100 most cited studies on obesity were included for further analysis. These studies were published from 1982 to 2017 in English language. Most of the studies were published as an article (n = 84). The highly cited study on obesity was “Establishing a standard definition for child overweight and obesity worldwide: international survey” published in BMJ-British Medical Journal (Impact Factor 39.890, Incites Journal Citation Reports, 2021) in 2000 cited 10,543 times. The average number of citations per study was 2,947.22 (ranging from 1,566 to 10,543 citations). Two studies had more than 10,000 citations. A total of 2,272 authors from 111 countries were involved. The most prolific author was Flegal KM authored 14 studies with 53,558 citations. The highly active country in obesity research was United States of America. The included studies were published in 33 journals. The most attractive journal was JAMA-Journal of the American Medical Association (Impact Factor 56.272) published 17 studies and cited globally 51,853 times. The most frequently used keywords were obesity (n = 87) and overweight (n = 22). The countries with highest total link strength was United States of America (n = 155), followed by England (n = 140), and Scotland (n = 130). Our results show that most number of highly cited studies were published in developed countries. The findings of this study can serve as a standard benchmark for researchers to provide the quality bibliographic references and insights into the future research trends and scientific cooperation in obesity research.
La música del Estallido social chileno: el despertar visto desde la ventana del acontecimiento
Authors: Fazio Luciana , Fazio Daniela , Pineda Ramos Carlos Andrés 
Published: December 2021

Este trabajo es un ejercicio investigativo sobre la historia del tiempo presente en el que mostramos cómo es posible volver inteligibles hechos en proximidad temporal al observador. Para ello, tomamos como caso de estudio las movilizaciones ocurridas durante el 2019 en Chile y, en particular, un corpus de canciones sobre el estallido difundidas en el canal de Youtube de Lavitrola.cl bajo el hashtag #únansealcanto. A partir de un análisis de lo que “cantan”, lo que “dicen” y lo que “hacen” los músicos exploramos cómo las canciones dan información y significación sobre el acontecimiento, y cómo ese acontecimiento puede ser en sí mismo una ventana para capturar el sentido del presente, para iluminar las dinámicas estructurales que le subyacen y para comprender las aspiraciones de sus principales actores.
Palabras clave: Acontecimiento, estallido social chileno, historia del tiempo presente, música, culturas digitales.
Exploration of Loneliness Among Black Older Adults
Authors: Ojembe Blessing Ugochi , Kalu Michael Ebe , Ezulike Chigozie Donatus , John Makanjuola Osuolale , Oyinlola Oluwagbemiga , Osifeso Temitope Adebanke , Ekoh Prince Chiagozie , Iwuagwu Anthony , Kapiriri Lydia 
Published: December 2021

Background: Loneliness is a public and social issue affecting older adults, but in varying degrees across ethnic groups. Black older adults (BOAs) are more prone to loneliness because they have unique and accumulated factors (e.g., low socioeconomic status, high number of chronic conditions) that predispose them to loneliness. This review aims to describe the extent and the nature of research activities on loneliness and identify the contributory factors to loneliness among BOAs as presented in the global literature.
Methods/Design: We will follow the five steps of Arksey and O’Malley’s (2005) framework to search multiple databases from inception till June 2021. MeSH terms and keywords, e.g., “older adults,” “blacks,” and “loneliness,” will be adopted for several databases, including CINHAL, Ageline, PsychINFO, Cochrane Central Registers of Control Trials, PubMed, Web of Science, Social Science Abstract. Multiple reviewers will independently screen citations (title/abstract and full text) and extract data using predefined inclusion and exclusion criteria. “Best fit” framework synthesis using the six social provisions of Weiss’ framework as a priori themes will guide the data analysis.
Discussion: This review will inform policy development around contributory factors for loneliness among BOAs and the most relevant issues on loneliness related to BOAs.
Humanitarian and Developmental Research Engagement during COVID-19
Authors: Schismenos Spyros , Stevens Garry J. , Georgeou Nichole , Emmanouloudis Dimitrios , Shrestha Surendra , Thapa Biraj S. 
Published: December 2021

Background: Floods and storms are the most common natural hazards. Communities in remote, riparian areas are the most vulnerable in such disasters, particularly when local populations lack reliable energy and early warning systems for hazard response. Our study will investigate energy and flood resilience issues in such communities and use remote methods to enable research continuity in intra and post-pandemic contexts.
Methods/Design: A two-round Delphi process will be used to interview 16 participants from Nepal and Greece to understand their priorities and preferred solutions for energy and flood resilience issues. In Round One we aim to understand the current capabilities and vulnerabilities of our focus communities in these areas. In Round Two, we seek feedback on potential options that are either market-available/evidence-informed solutions or co-developed conceptual systems. Remotely deployed semi-structured interviews are the principal method for both rounds. The Round Two structured comparative review also employs choice-based conjoint analysis and SCORE analysis.
Discussion: By collecting information from both professionals and non-experts, we aim to understand what options are perceived as reliable, realistic and appropriate for flood-prone communities. The remote research design enables continuity and community access to development-focused research and its outputs, and a flexible, cost-effective approach for researchers and partner organizations.
Transcriptomic identification of HBx-associated hub genes in hepatocellular carcinoma
Authors: Ni Zhengzhong , Lu Jun , Huang Weiyi , Khan Hanif , Wu Xuejun , Huang Danmei , Shi Ganggang , Niu Yongdong , Huang Haihua 
Published: December 2021

Background
Hepatocellular carcinoma (HCC) is one of the most common malignancies around the world. Among the risk factors involved in liver carcinogenesis, hepatitis B virus (HBV) X protein (HBx) is considered to be a key regulator in hepatocarcinogenesis. Whether HBx promotes or protects against HCC remains controversial, therefore exploring new HBx-associated genes is still important.

Methods
HBx was overexpressed in HepG2, HepG2.2.15 and SMMC-7721 cell lines, primary mouse hepatocytes and livers of C57BL/6N mice. High-throughput RNA sequencing profiling of HepG2 cells with HBx overexpression and related differentially-expressed genes (DEGs), pathway enrichment analysis, protein-protein interaction networks (PPIs), overlapping analysis were conducted. In addition, Gene Expression Omnibus (GEO) and proteomic datasets of HBV-positive HCC datasets were used to verify the expression and prognosis of selected DEGs. Finally, we also evaluated the known oncogenic role of HBx by oncogenic array analysis.

Results
A total of 523 DEGs were obtained from HBx-overexpressing HepG2 cells. Twelve DEGs were identified and validated in cells transiently transfected with HBx and three datasets of HBV-positive HCC transcription profiles. In addition, using the Kaplan-Meier plotter database, the expression levels of the twelve different genes were further analyzed to predict patient outcomes.

Conclusion
Among the 12 identified HBx-associated hub genes, HBV-positive HCC patients expressing ARG1 and TAT showed a good overall survival (OS) and relapse-free survival (RFS). Thus, ARG1 and TAT expression could be potential prognostic markers.
Altered executive control network connectivity in anti‐NMDA receptor encephalitis
Authors: Chen Zhongqin , Zhou Jintao , Wu Dengchang , Ji Caihong , Luo Benyan , Wang Kang 
Published: December 2021

AbstractObjectiveThe goal of this study was to examine whether the static functional connectivity (FC) of the executive control network (ECN) and the temporal properties of dynamic FC states in the ECN can characterize the underlying nature of anti‐N‐methyl‐d‐aspartate (anti‐NMDA) receptor encephalitis and their correlations with cognitive functions.MethodsIn total, 21 patients with anti‐NMDA receptor encephalitis past the acute stage and 23 healthy controls (HCs) underwent a set of neuropsychological tests and participated in a resting‐state fMRI study to analyse the static FC of the ECN and the temporal properties of dynamic FC states in the ECN. In addition, correlation analyses were performed to determine the correlations between the FC metrics and cognitive performance.ResultsPatients with anti‐NMDA receptor encephalitis past the acute stage showed significant cognitive impairments compared to HCs. In accord with the results of neuropsychological tests, static intrinsic FC alterations and changed dynamic FC metrics of ECN were observed in the patients. Importantly, we observed significant correlations between altered ECN metrics and working memory, information processing speed, executive function performance in the patients.InterpretationOur findings suggest that cognitive impairments in patients with anti‐NMDA receptor encephalitis past the acute stage are likely related to altered static and dynamic ECN connectivity. These observations may enhance our understanding of the pathophysiological mechanisms underlying cognitive function in this population.
Remember to stay positive: Affect and prospective memory in everyday life
Authors: Pupillo Francesco , Powell Daniel , Phillips Louise H. , Schnitzspahn Katharina 
Published: December 2021

AbstractThe present study aimed to investigate the affect‐cognition interplay in young and older adults by studying prospective memory (PM), the realisation of delayed intentions. While most previous studies on the topic were conducted in the laboratory, we examined the influence of naturally occurring affect on PM tasks carried out in participants' everyday lives. For seven consecutive days, participants were asked to rate their affective state nine times per day and send text messages either at specific times (time‐based PM) or when a particular event occurred (event‐based PM). Results showed that within‐participants changes in valence from more positive to more negative affect were associated with decreased PM performance. This was similarly true for young and older adults. The design used allowed linkage of within‐participants fluctuations of affect and cognitive functions, constituting a methodological advancement. Results suggest that positive affect has the potential to improve cognitive functioning in everyday life.
Organelle‐Specific Anchored Delivery System Stretching a Reversal of Tumor Hypoxia Microenvironment to a Combinational Chemo‐Photothermal Therapy
Authors: Chen Xuerui , Yin Xuelian , Zhan Lin , Zhang Junfeng , Zhang Yuxi , Wu Yinghua , Ju Jiale , Li Yajie , Xue Qianghua , Wang Xu , Li Chenchen , Reis Rui L. , Wang Yanli 
Published: December 2021

AbstractDirect delivery to an organelle‐specific point can boost the efficacy of therapy procedures to new heights. Among other subcellular organelles, mitochondria generate ATP as intracellular powerhouse, and are associated with multiple aspects of tumorigenesis and tumor development. Here, a mitochondrial anchored biomimetic nanoplatform (CZACN) is designed and its reversal of tumor hypoxia microenvironment underlying the mitochondria‐located chemo‐photothermal therapy is studied. After shuttling into cancer cells, therapeutic payloads including cisplatin (CDDP) and Au nanozymes are controllably released in the ATP‐overexpressed mitochondria. CDDP generates O2•−, forms H2O2 for a chemical fuel in the next reaction, and damages mitochondrial DNA. Meanwhile, the catalase‐like Au nanozymes catalyze the produced hydrogen peroxide for oxygen supply to relieve hypoxic tumor microenvironment, offering cytotoxic singlet oxygen against cancer cells under NIR treatment. As a result of cancer‐cell self‐recognition, mitochondria‐targeted therapy, and photothermal conversion ability, the fabricated CZACNs obtained 89.2 ± 3.70% of tumor growth inhibition under NIR irradiation and constrained the dose‐limiting toxicity of CDDP, as well. These findings reinforce the synergistic effect of organelle‐specific navigation and in situ oxygen self‐sufficiency for combinational chemo‐photothermal therapy.
Anomalous Optoelectric Properties of an Ultrathin Ruthenium Film with a Surface Oxide Layer for Flexible Transparent Conducting Electrodes
Authors: Oh Jae Myoung , Nasir Mohammad , Ryu Byungki , Yun Hyung Joong , Choi Chel‐Jong , Bae Jong‐Seong , Park Hee Jung 
Published: December 2021

AbstractThe growing industrial demand for flexible optoelectric devices has led to intensive researches on highly flexible transparent electrode materials such as graphene, reduced graphene‐oxide (r‐GO), Ag‐nanowire, and 2D metal oxides. However, except Ag‐nanowire, transparent electrode materials having optoelectric properties comparable to that of indium–tin–oxide (ITO) have not yet been developed. In this study, an ultrathin ruthenium film with a ruthenium oxide (RuO2) subsurface layer has been introduced as a flexible transparent electrode. The metallic Ru thin film is fabricated from a RuO2 nanosheet using a layer‐by‐layer coating technique, followed by thermal reduction. The thin film (≈6 nm) reveals comparable sheet resistance and transmittance as that of conventional ITO electrodes. The high transmittance (≈79%) of the metal thin film in the visible range is attributed to the presence of an oxide subsurface layer which acts as antireflection. The Ru film (with oxide subsurface layer) with figure‐of‐merit ≈3.4 × 10−4 Ω−1 shows the best performance among the thin films fabricated using a wet‐chemistry process with 2D nanosheets including graphene, r‐GO, and other metal oxides. In addition, the high mechanical flexibility of Ru thin film makes it next‐generation flexible transparent conducting electrodes, beyond graphene, r‐GO, and 2D metal oxides.
Introducing NO3– into Carbonate‐Based Electrolytes via Covalent Organic Framework to Incubate Stable Interface for Li‐Metal Batteries
Authors: Wen Yucheng , Ding Jieying , Yang Yan , Lan Xuexia , Liu Jun , Hu Renzong , Zhu Min 
Published: December 2021

AbstractLithium nitrate (LiNO3) as an effective additive to construct stable solid electrolyte interface (SEI) is generally applied in ether‐based electrolytes, but its poor solubility in carbonate‐based electrolytes limits further application for Li metal batteries (LMBs). Therefore, an engineering of introducing NO3– into carbonate‐based electrolytes by synthesizing targeted covalent organic framework (EB‐COF:NO3) to modify Li anode for incubating a reliable SEI is reported. Its unique structure not only facilitates the desolvation process of lithium ions (Li+) to accelerate the transport of Li+, but also releases NO3– to form beneficial Li3N, LiNxOy species to in situ construct a stable SEI. With the application of EB‐COF:NO3, the cycling and rate performance of (50 µm) Li//LiFePO4 full cell is comprehensively improved under the conditions of poor electrolyte and high loading, significantly increasing capacity retention from 14% to 94% after 200 cycles. And the high voltage Li//LiNi0.5Mn1.5O4 full cell still demonstrates excellent cycling stability with the capacity retention of 92% after 600 cycles. Accordingly, this strategy shares a prospect for the application of covalent organic frameworks (COFs) to build a stable SEI for high‐energy‐density LMBs, and also broadens the application of LiNO3 in carbonate‐based electrolytes.
Engineering Pocket‐Like Graphene–Shell Encapsulated FeS2: Inhibiting Polysulfides Shuttle Effect in Potassium‐Ion Batteries
Authors: Chen Bochao , Ding Jiawei , Bai Xiangren , Zhang Hanwen , Liang Ming , Zhu Shan , Shi Chunsheng , Ma Liying , Liu Enzuo , Zhao Naiqin , He Fang , Zhou Wei , He Chunnian 
Published: December 2021

AbstractResource‐rich FeS2 is a promising anode for potassium‐ion batteries (PIBs). However, polysulfides emerge due to FeS2 conversion during discharging, which dissolve into the ether‐based electrolyte and cause the continuous capacity degradation in PIBs. To address the polysulfides dissolution in PIBs, a graphene–shell‐encapsulated FeS2 is fabricated and embedded in N/S codoped 3D hollow carbon spheres. As a protective pocket, the graphene–shell can effectively accommodate polysulfides inside the core–shell, inhibiting the polysulfides shuttle effect to enhance cycle stability of electrode. The density functional theory (DFT) calculations demonstrate that graphene–shells have a strong adsorption capacity for polysulfides, and the interfacial interaction between KFeS2 and graphene–shell can boost the K ion mobility. As a result, the composite exhibits superior‐rate properties (524 and 224 mA h g−1 at 0.1 and 8 A g−1, respectively) and long‐term cycle stability. This work demonstrates the promotion and protective effect of the graphene–shell for the FeS2 to storage K from both experimental and computational perspectives. These research outputs can provide guidance for designing other metal‐based sulfide electrodes for PIBs.
Monolithic Task‐Specific Ionogel Electrolyte Membrane Enables High‐Performance Solid‐State Lithium‐Metal Batteries in Wide Temperature Range
Authors: Yu Le , Yu Lu , Liu Qing , Meng Tao , Wang Sen , Hu Xianluo 
Published: December 2021

AbstractMonolithic ionogel electrolyte membranes (IGEMs) based on gelling scaffolds and ionic liquids have aroused intensive interest because of their broad processing compatibility, nonflammability, and favorable thermal and electrochemical features. However, the absence of functional scaffolds that concurrently enable high mechanical strength and Li+ transportability of IGEMs constrains the battery power and safety. Herein, a task‐specific IGEM monolith featuring high Li+ conductivity and outstanding thermal stability is demonstrated, whereby electrospun positively charged poly(ionic liquid) nanofibers serve as a thermotolerant scaffold for the IGEM. Regulating the Li+ environment in the IGEM enables the shift from the sluggish vehicular to fast structural Li‐ion transport mode. With the unique IGEM, the solid‐state Li||LiFePO4 cells achieve improved rate capability and good cyclability in a wide temperature range from 0 to 90 °C. Furthermore, practical solid‐state Li||LiFePO4 pouch cells with a cathode capacity of ≈2 mAh cm−2 have also been demonstrated.
Hydrogenated Oxide Material for Self‐Targeting and Automatic‐Degrading Photothermal Tumor Therapy in the NIR‐II Bio‐Window
Authors: Zhu Qing , Jiang Wei , Ye Ke , Jin Shunru , Dong Wang , Liu Songde , Zhang Guozhen , Tian Chao , Luo Yi , Wang Yucai , Jiang Jun 
Published: December 2021

AbstractDeveloping photothermal agents (PTAs) for tumor therapy has three prerequisites: selectively targeting tumors, efficiently converting near‐infrared (NIR) photoenergy to heat, and degrading after the cure. These make up a combination rarely found in one material. Here a metal‐acid treatment is reported to hydrogenate metal oxide, bestowing the produced HxMoO3 with metal‐like electronic structure which enables harvesting NIR‐II light (1000−1350 nm wavelength). Importantly, created by putting acid protons into oxide, the HxMoO3 nanomaterial can resist attacking from protons in acids but is vulnerable to hydroxyl ions in alkaline. After entering biological organism, HxMoO3 PTAs persist long in acidic tumor microenvironment (TME, extracellular pH 6.5–6.9) while degrade quickly under the normal physiological environment (pH 7.2−7.4), naturally causing tumor‐selective accumulation. Under 1064 nm NIR‐II illumination, the HxMoO3 achieves a high photothermal conversion efficiency of 60.9%, leading to a high tumor inhibition rate of ≈97.25%. Such a novel PTAs integrates merits of metal and oxide, opening a door of smart photothermal therapy with self‐adaptive tumor‐accumulation and automatic degradation after tumor hyperthermia.
Bacteria‐Targeting Photodynamic Nanoassemblies for Efficient Treatment of Multidrug‐Resistant Biofilm Infected Keratitis
Authors: Zhu Yiwen , Wu Shijing , Sun Yujie , Zou Xuan , Zheng Liang , Duan Shun , Wang Julin , Yu Bingran , Sui Ruifang , Xu Fu‐Jian 
Published: December 2021

AbstractMultidrug‐resistant Pseudomonas aeruginosa (MDR‐P. aeruginosa) cannot be extirpated with any of the antipseudomonal antibiotics available in clinic because P. aeruginosa exhibit natural resistance to antibiotics and form a stable biofilm. Biofilm formed by P. aeruginosa is a leading cause of bacterial keratitis which may cause corneal perforation and even blindness. Antibacterial photodynamic therapy (aPDT) is a promising bactericidal method in combatting drug‐resistant bacteria. Unfortunately, the use of broad‐spectrum aPDT that kills bacteria indiscriminately may lead to microbiota imbalance and cause serious side effects in normal cells. Herein, PαGal50‐b‐PGRB20, which can effectively disperse biofilms and selectively kill MDR‐P. aeruginosa inside biofilms by binding to Lec A in the extracellular polymeric substances and on the P. aeruginosa membrane with low phototoxicity caused by broad‐spectrum aPDT, is designed and synthesized. PαGal50‐b‐PGRB20 has bactericidal activities by damaging DNA, RNA, protein, and membrane. In vivo study of the MDR‐P. aeruginosa biofilm infected keratitis model demonstrates the potential of PαGal50‐b‐PGRB20 for a better corneal recovery. This work provides a dedicated antibacterial material for preferentially killing MDR‐P. aeruginosa over normal cells and other bacteria.