bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functionalized Materials as a Versatile Platform for Enzyme Immobilization in Wastewater Treatment
Authors: Kołodziejczak-Radzimska Agnieszka , Nghiem Long D. , Jesionowski Teofil 
Published: June 2021

Abstract
Purpose of Review
Untreated wastewater discharge can significantly and negatively impact the state of the environment. Rapid industrialization and economic development have directly contributed to land and water pollution resulting from the application of many chemicals such as organic dyes, pharmaceuticals, and industrial reagents. The removal of these chemicals before effluent discharge is crucial for environmental protection. This review aims to explore the importance of functionalized materials in the preparation of biocatalytic systems and consider their application in eliminating water pollutants.

Recent Findings
Wastewater treatment methods can be classified into three groups: (i) chemical (e.g., chemical oxidation and ozonation), (ii) physical (e.g., membrane separation and ion exchange), and (iii) biological processes. Biological treatment is the most widely used method due to its cost-effectiveness and eco-friendliness. In particular, the use of immobilized enzymes has recently become more attractive as a result of scientific progress in advanced material synthesis. The selection of an appropriate support plays an important role in the preparation of such biologically active systems. Recent studies have demonstrated the use of various materials for enzyme immobilization in the purification of water.

Summary
This review identifies and discusses different biocatalytic systems used in the enzymatic degradation of various water pollutants. Materials functionalized by specific groups can serve as good support matrices for enzyme immobilization, providing chemical and thermal stability to support catalytic reactions. Enzymatic biocatalysis converts the pollutants into simpler products, which are usually less toxic than their parents. Due to immobilization, the enzyme can be used over multiple cycles to reduce the cost of wastewater treatment. Future studies in this field should focus on developing new platforms for enzyme immobilization in order to improve degradation efficiency.
A hybrid ant colony algorithm based on multiple strategies for the vehicle routing problem with time windows
Authors: Wu Hongguang , Gao Yuelin , Wang Wanting , Zhang Ziyu 
Published: June 2021

AbstractIn this paper, we propose a vehicle routing problem with time windows (TWVRP). In this problem, we consider a hard time constraint that the fleet can only serve customers within a specific time window. To solve this problem, a hybrid ant colony (HACO) algorithm is proposed based on ant colony algorithm and mutation operation. The HACO algorithm proposed has three innovations: the first is to update pheromones with a new method; the second is the introduction of adaptive parameters; and the third is to add the mutation operation. A famous Solomon instance is used to evaluate the performance of the proposed algorithm. Experimental results show that HACO algorithm is effective against solving the problem of vehicle routing with time windows. Besides, the proposed algorithm also has practical implications for vehicle routing problem and the results show that it is applicable and effective in practical problems.
Labour Market Regulation and Youth Unemployment in the EU-28
Authors: Liotti Giorgio 
Published: June 2021

AbstractThe rise of youth unemployment has been one of the most serious problems which policymakers have had to deal with over the last two decades. Neoclassical economic theory suggests that the deregulation (i.e. higher flexibility) of the labour market stimulates firms to hire young people and—therefore—reduces youth unemployment. The aim of this study is to empirically test the validity of this hypothesis, analysing data on youth unemployment and labour market regulation index (LMRI) for 28 European countries in the period between 2000 and 2018. The empirical results—using two different econometric techniques (time and fixed effects that allows to take into account the presence of heterogeneity of countries in the model and pooling mean group (PMG) estimator providing results about the short and long run relationship between LMRI and youth unemployment)—do not provide evidence in support of the neoclassical hypothesis. In particular, the effect of higher flexibility of the labour market is negative and statistically significant (at 1%) only when a dummy variable for the Eastern country group is included in the model. Vice-versa, the paper shows that higher economic growth and higher investment in active labour market policy represent the key variables to reduce the youth unemployment. In conclusion, the paper raises many doubts that the introduction of flexibility measures in itself can represent a useful tool to counteract the increase of youth unemployment in Europe.
Design Engineering, Synthesis Protocols, and Energy Applications of MOF-Derived Electrocatalysts
Authors: Radwan Amr , Jin Huihui , He Daping , Mu Shichun 
Published: June 2021

AbstractThe core reactions for fuel cells, rechargeable metal–air batteries, and hydrogen fuel production are the oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER), which are heavily dependent on the efficiency of electrocatalysts. Enormous attempts have previously been devoted in non-noble electrocatalysts born out of metal–organic frameworks (MOFs) for ORR, OER, and HER applications, due to the following advantageous reasons: (i) The significant porosity eases the electrolyte diffusion; (ii) the supreme catalyst–electrolyte contact area enhances the diffusion efficiency; and (iii) the electronic conductivity can be extensively increased owing to the unique construction block subunits for MOFs-derived electrocatalysis. Herein, the recent progress of MOFs-derived electrocatalysts including synthesis protocols, design engineering, DFT calculations roles, and energy applications is discussed and reviewed. It can be concluded that the elevated ORR, OER, and HER performances are attributed to an advantageously well-designed high-porosity structure, significant surface area, and plentiful active centers. Furthermore, the perspectives of MOF-derived electrocatalysts for the ORR, OER, and HER are presented.
Constructing Race and Ethnicity: “It Has to Do with Where You Are”
Authors: Carney Nikita 
Published: June 2021

AbstractDrawing from the lived experiences of Haitian women in Boston and Montreal, this study illustrates how ethnography can augment understandings of race and place in demography by complementing quantitative analyses, showing how race is constructed across place through daily micro-interactions. Building on the work of demographers who examine how race shifts over time and place, this article challenges the practice of engaging with race as a fixed or static category to consider how race is constructed across place, highlighting the nuances of race that are sometimes lost in quantitative studies. The multi-sited ethnographic methodology employed in this study is uniquely suited to uncovering the specificities of race and place. The findings reveal that Haitian women experience race differently in Montreal and in Boston, based largely on the historical context of each place. Haitians in Boston experienced intraracial tensions with African Americans, particularly during the 1960s and 1970s, that shaped their experiences of race and place, while Haitians in Montreal at the same time experienced Blackness that was closely tied with xenophobia in the French Canadian context. The Haitian women in this study experienced race, place, gender, ethnicity, and class simultaneously, necessitating an intersectional approach to understanding the effects of race in and on their daily lives.
Honesty‐Humility and unethical behavior in adolescents: The mediating role of moral disengagement and the moderating role of system justification☆
Authors: Guo Zhen , Li Wenqi , Yang Ying , Kou Yu 
Published: June 2021

ABSTRACTIntroductionHonesty‐Humility represents the tendency to be fair, genuine, and cooperative in social interactions. Although previous evidence has demonstrated that Honesty‐Humility is related to decreased unethical behavior, little is known about the mediating and moderating mechanisms underlying this relationship, especially among adolescents. Based on social cognitive theory and system justification theory, the present study aims to examine the mediating role of moral disengagement and the moderating role of system justification in the relationship between Honesty‐Humility and unethical behavior among Chinese adolescents.MethodsA large sample of Chinese adolescents (N = 2,576, 47% boys; Mage = 17.00 years, SD = 1.07) was recruited from four senior high schools. The participants completed questionnaires regarding Honesty‐Humility, moral disengagement, system justification, and unethical behavior.ResultsThe findings suggested that Honesty‐Humility was negatively associated with adolescents’ unethical behavior, and moral disengagement partially mediated this negative association. Furthermore, system justification moderated the mediation model. Specifically, the negative relationships between Honesty‐Humility and moral disengagement/unethical behavior were stronger among adolescents who perceive the society as fair.ConclusionThese findings advance the understanding of when and how Honesty‐Humility prevents adolescents from unethical behavior. The theoretical and practical implications of the current study as well as future research directions are discussed.
Negotiating medical services in the Madras Presidency: the subordinate perspectives (1882–1935)
Authors: Chakraborty Arnab 
Published: June 2021

AbstractThe historiography of western medicine in colonial India has predominantly been analysed from the perspectives of the elite services – the Indian Medical Service (IMS) and their recruits. Unfortunately, perceiving colonial medical practices through the lens of the IMS has remained inadequate to provide a nuanced understanding of the role played by Indians in the semi-urban and rural areas of colonial India. This article examines the contributions of local administration and the role played by the recruits of the Subordinate Medical Service. This article uses the Madras Presidency as its case study and focusses on the medical subordinates who were pivotal in establishing a western medical tradition in the region. This will shift the urban-centric focus and examine mostly the rural parts of the presidency, in particular, the district hospitals and dispensaries located in the districts,taluksand villages. The article analyses the transformation in the Madras medical administration from the late nineteenth century until 1935 to argue how subordinates were the ones controlling the local medical services, and thus pulling the strings of health administration in the presidency. This will also demonstrate the uniqueness of Madras and how it disseminated western medical care with an active participation and involvement of the local residents.
A Preliminary Test of the Impact of De-Globalization on MNC Performance
Authors: Peretz Hilla , Morley Michael J. 
Published: June 2021

ABSTRACTWe offer a preliminary examination of whether national and organizational level contexts amplify or reduce the effects of de-globalization on the performance of MNCs. Theoretically, we borrow ideas from both event system theory and institutional fit to propose a model explicating key dimensions of the relationship between de-globalization, national and organizational context, and MNC performance. We then test our ideas using data assembled from 283 MNCs in 20 countries. We find that while de-globalization has a negative effect on MNC performance, national and organizational level contextual endowments do moderate this relationship. We discuss some implications of our findings and highlight attendant limitations.
Who Not What: The Logic of China's Information Control Strategy
Authors: Gallagher Mary , Miller Blake 
Published: June 2021

AbstractIn this paper, we examine how the Chinese state controls social media. While social media companies are responsible for censoring their platforms, they also selectively report certain users to the government. This article focuses on understanding the logic behind media platforms’ decisions to report users or content to the government. We find that content is less relevant than commonly thought. Information control efforts often focus on who is posting rather than on what they are posting. The state permits open discussion and debate on social media while controlling and managing influential social forces that may challenge the party-state's hegemonic position. We build on Schurmann's “ideology and organization,” emphasizing the Party's goals of embedding itself in all social structures and limiting the ability of non-Party individuals, networks or groups to carve out a separate space for leadership and social status. In the virtual public sphere, the Chinese Communist Party (CCP) continues to apply these principles to co-opt, repress and limit the reach of influential non-Party “thought leaders.” We find evidence to support this logic through qualitative and quantitative analysis of leaked censorship documents from a social media company and government documents on information control.
Appropriation, Integration, and Nation Building: Portuguese Railways in the Second Half of the Nineteenth and Early Years of the Twentieth Century
Authors: Pereira Hugo Silveira 
Published: June 2021

AbstractIn 1850, after three decades of political turmoil, Portugal started investing in major public works, particularly, in the construction of a national railway network. This strategy followed closely the suggestions of the Saint-Simonian technocrats with whom Portuguese engineers had been engaging since the 1820s. Additionally, it came in response to the longtime neglect suffered by the Portuguese transportation system, which hindered communications and trade between different areas of the kingdom and with neighboring Spain. The main goal of the investment was to modernize the national transport system, attract to Portuguese harbors a large portion of the traffic between Europe, Africa, and America, and, in general terms, put the nation on the path of progress. By the end of the nineteenth century, total mileage of the Portuguese rail network exceeded 2,300 km. This article analyzes the role of railways in the improvement of communications between the Portuguese provinces, their appropriation in a unified nation-state, the degree of integration of the Portuguese economy with the Spanish and European economies, and the construction/reinvention of Portugal as a modern and technological nation. To achieve these goals, I will use three key concepts: territorial appropriation, circulation, and globalization. Sources include statistics of railway operation and previous works analyzing the impact of railways on the Portuguese transport system and economy, the outcomes of operating transnational lines, and the importance of technology for the reinvention of Portugal during the second half of the nineteenth century.
Seismic Noise Autocorrelations on Mars
Authors: Schimmel Martin , Stutzmann Eleonore , Lognonné Philippe , Compaire Nicolas , Davis Paul , Drilleau Melanie , Garcia Raphael , Kim Doyeon , Knapmeyer‐Endrun Brigitte , Lekic Vedran , Margerin Ludovic , Panning Mark , Schmerr Nicholas , Scholz John Robert , Spiga Aymeric , Tauzin Benoit , Banerdt Bruce 
Published: June 2021

AbstractMars is the first extraterrestrial planet with seismometers (Seismic Experiment for Interior Structure, SEIS) deployed directly on its surface in the framework of the Interior Exploration using Seismic Investigations, Geodesy and Heat Transport (InSight) mission. The lack of strong Marsquakes, however, strengthens the need of seismic noise studies to additionally constrain the Martian structure. Seismic noise autocorrelations of single‐station recordings permit the determination of the zero‐offset reflection response underneath SEIS. We present a new autocorrelation study which employs state‐of‐the‐art approaches to determine a robust reflection response by avoiding bias from aseismic signals which are recorded together with seismic waves due to unfavorable deployment and environmental conditions. Data selection and segmentation is performed in a data‐adaptive manner which takes the data root‐mean‐square amplitude variability into account. We further use the amplitude‐unbiased phase cross‐correlation and work in the 1.2–8.9 Hz frequency band. The main target are crustal scale reflections, their robustness and convergence. The strongest signal appears at 10.6 s, and, if interpreted as a P‐wave reflection, would correspond to a discontinuity at about 21 km depth. This signal is a likely candidate for a reflection from the base of the Martian crust due to its strength, polarity, and stability. Additionally we identify, among the stable signals, a signal at about 6.15 s that can be interpreted as the P‐wave reflection from the mid‐crust at about 9.5 km depth.
Extensive Remineralization of Peatland‐Derived Dissolved Organic Carbon and Ocean Acidification in the Sunda Shelf Sea, Southeast Asia
Authors: Zhou Yongli , Evans Christopher D. , Chen Yuan , Chang Kristy Y. W. , Martin Patrick 
Published: June 2021

AbstractSoutheast Asia is a hotspot of riverine export of terrigenous organic carbon to the ocean, accounting for ∼10% of the global land‐to‐ocean riverine flux of terrigenous dissolved organic carbon (tDOC). While anthropogenic disturbance is thought to have increased the tDOC loss from peatlands in Southeast Asia, the fate of this tDOC in the marine environment and the potential impacts of its remineralization on coastal ecosystems remain poorly understood. We collected a multi‐year biogeochemical time series in the central Sunda Shelf (Singapore Strait), where the seasonal reversal of ocean currents delivers water masses from the South China Sea first before (during Northeast Monsoon) and then after (during Southwest Monsoon) they have mixed with run‐off from peatlands on Sumatra. The concentration and stable isotope composition of DOC, and colored dissolved organic matter spectra, reveal a large input of tDOC to our site during Southwest Monsoon. Using isotope mass balance calculations, we show that 60%–70% of the original tDOC input is remineralized in the coastal waters of the Sunda Shelf, causing seasonal acidification. The persistent CO2 oversaturation drives a CO2 efflux of 2.4–4.9 mol m−2 yr−1 from the Singapore Strait, suggesting that a large proportion of the remineralized peatland tDOC is ultimately emitted to the atmosphere. However, incubation experiments show that the remaining 30%–40% tDOC exhibits surprisingly low lability to microbial and photochemical degradation, suggesting that up to 20%–30% of peatland tDOC might be relatively refractory and exported to the open ocean.
Field-emission electron gun for a MEMS electron microscope
Authors: Krysztof Michał 
Published: June 2021

AbstractThis article presents a field-emission electron gun intended for use in a MEMS (microelectromechanical system) electron microscope. Its fabrication process follows the technology of a miniature device under development built from silicon electrodes and glass spacers. The electron gun contains a silicon cathode with a single very sharp protrusion and a bundle of disordered CNTs deposited on its end (called a sharp silicon/CNT cathode). It was tested in diode and triode configurations. For the diode configuration, a low threshold voltage <1000 V and a high emission current that reached 90 µA were obtained. After 30 min of operation at 900 V, the emission current decreased to 1.6 µA and was stable for at least 40 min, with RMS fluctuation in the anode current lower than 10%. The electron beam spot of the source was observed on the phosphor screen. In the diode configuration, the spot size was the same as the emission area (~10 µm), which is a satisfactory result. In the triode configuration, an extraction electrode (gate) control function was reported. The gate limited the emission current and elongated the lifetime of the gun when the current limit was set. Moreover, the electron beam current fluctuations at the anode could be reduced to ~1% by using a feedback loop circuit that controls the gate voltage, regulating the anode current. The developed sharp silicon/CNT cathodes were used to test the MEMS electron source demonstrator, a key component of the MEMS electron microscope, operating under atmospheric pressure conditions. Cathodoluminescence of the phosphor layer (ZnS:Ag) deposited on the thin silicon nitride membrane (anode) was observed.
IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R
Authors: Qiao Chenyang , Huang Wenjie , Chen Jie , Feng Weibo , Zhang Tongyue , Wang Yijun , Liu Danfei , Ji Xiaoyu , Xie Meng , Sun Mengyu , Fan Daiming , Wu Kaichun , Xia Limin 
Published: June 2021

AbstractMetastasis is the major reason for the high mortality of colorectal cancer (CRC) patients and its molecular mechanism remains unclear. Here, we report a novel role of Homeobox A13 (HOXA13), a member of the Homeobox (HOX) family, in promoting CRC metastasis. The elevated expression of HOXA13 was positively correlated with distant metastasis, higher AJCC stage, and poor prognosis in two independent CRC cohorts. Overexpression of HOXA13 promoted CRC metastasis whereas downregulation of HOXA13 suppressed CRC metastasis. Mechanistically, HOXA13 facilitated CRC metastasis by transactivating ATP-citrate lyase (ACLY) and insulin-like growth factor 1 receptor (IGF1R). Knockdown of ACLY and IGFIR inhibited HOXA13-medicated CRC metastasis, whereas ectopic overexpression of ACLY and IGFIR rescued the decreased CRC metastasis induced by HOXA13 knockdown. Furthermore, Insulin-like growth factor 1 (IGF1), the ligand of IGF1R, upregulated HOXA13 expression through the PI3K/AKT/HIF1α pathway. Knockdown of HOXA13 decreased IGF1-mediated CRC metastasis. In addition, the combined treatment of ACLY inhibitor ETC-1002 and IGF1R inhibitor Linsitinib dramatically suppressed HOXA13-mediated CRC metastasis. In conclusion, HOXA13 is a prognostic biomarker in CRC patients. Targeting the IGF1-HOXA13-IGF1R positive feedback loop may provide a potential therapeutic strategy for the treatment of HOXA13-driven CRC metastasis.
Discovery of a cooperative mode of inhibiting RIPK1 kinase
Authors: Meng Huyan , Wu Guowei , Zhao Xinsuo , Wang Anhui , Li Dekang , Tong Yilun , Jin Taijie , Cao Ye , Shan Bing , Hu Shichen , Li Ying , Pan Lifeng , Tian Xiaoxu , Wu Ping , Peng Chao , Yuan Junying , Li Guohui , Tan Li , Wang Zhaoyin , Li Ying 
Published: June 2021

AbstractRIPK1, a death domain-containing kinase, has been recognized as an important therapeutic target for inhibiting apoptosis, necroptosis, and inflammation under pathological conditions. RIPK1 kinase inhibitors have been advanced into clinical studies for the treatment of various human diseases. One of the current bottlenecks in developing RIPK1 inhibitors is to discover new approaches to inhibit this kinase as only limited chemotypes have been developed. Here we describe Necrostatin-34 (Nec-34), a small molecule that inhibits RIPK1 kinase with a mechanism distinct from known RIPK1 inhibitors such as Nec-1s. Mechanistic studies suggest that Nec-34 stabilizes RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain. Furthermore, we show that Nec-34 series of compounds can synergize with Nec-1s to inhibit RIPK1 in vitro and in vivo. Thus, Nec-34 defines a new strategy to target RIPK1 kinase and provides a potential option of combinatorial therapy for RIPK1-mediated diseases.