bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and Risk Factors of Acute Kidney Injury After Femoral Neck Fracture in Elderly Patients: A Retrospective Case-Control Study
Authors: Zhan Sizheng , Xie Wenyong , Yang Ming , Zhang Dianying , Jiang Baoguo 
Published: August 2021

Abstract
Background: Hip fracture is highly associated with disability and consequently mortality in the elderly population. Postoperative acute kidney injury (AKI) is not unusual and is associated with considerable morbidity and mortality. We aimed to determining the incidence and potential risk factors for postoperative AKI in elderly patients with femoral neck fracture.Methods: We retrospectively evaluated patients over 65 years of age who had been subjected to surgery for femoral neck fracture at Peking University People's Hospital from January 2015 to December 2019. Demographic characteristics and potential risk factors were collected. AKI was defined according to the Kidney Disease Improving Global Outcomes guidelines.Results: A total of 308 elderly patients with femoral neck fracture were included in the study. The overall incidence of postoperative AKI was 12% (37 cases). Through binary logistic regression analysis, adjusted for age, intraoperative blood loss and BMI, we identified that early postoperative albumin, perioperative average hemoglobin and intraoperative hypotension are independent risk factors for postoperative AKI. The model considering the three factors can improve accuracy of predicting the possibility of developing AKI.Conclusion: The incidence of postoperative AKI in elderly patients with femoral neck fracture was 12%. Independent risk factors included early postoperative albumin, perioperative average hemoglobin and intraoperative hypotension. Taking multiple possible factors into consideration can better predict the possibility of developing AKI after surgery for elderly patients.
Long Non-Coding RNA ADAMTS9-AS1 Represses Ferroptosis of Endometrial Stromal Cells Through Regulating miR-6516-5p/GPX4 Axis in Endometriosis
Authors: Wan Yiting , Gu Cancan , Kong Jueying , Sui Jin , Zuo Ling , Song Yanhua , Chen Jing 
Published: August 2021

Abstract
Endometriosis (EMs) is one of the most frequent diseases in reproductive age women, characterized by the growth of endometrial tissues beyond the uterus. Enhanced proliferative and migratory potential of endometrial stromal cells (ESCs) is the major cause of EMs. Mounting studies have demonstrated that long non-coding RNAs (lncRNAs) exert an important role in regulating the development and progression of EMs. Given the aberrant expression of lncRNA ADAMTS9-AS1 in ectopic endometrium (ecEM), here we investigated the biological effect of ADAMTS9-AS1 on ESCs proliferation and migration and explored the underlying mechanism. The current data showed that the ADAMTS9-AS1 expression was significantly up-regulated in ecEM compared with eutopic endometrium (euEM) in patients with EMs and in a murine model of EMs. Functionally, ADAMTS9-AS1 knockdown in ectopic ESCs (EESCs) decreased cell viability and migration, whereas ADAMTS9-AS1 overexpression in normal ESCs (NESCs) enhanced cell viability and migration. More important, the effect of ADAMTS9-AS1 inhibition on decreasing ESCs viability was significantly blocked by Ferrostatin-1 (Fer-1, a ferroptosis inhibitor), and ADAMTS9-AS1 overexpression repressed Erastin (a ferroptosis activator)-induced cell death. Furthermore, the regulatory role of ADAMTS9-AS1 in ferroptosis was defined and evidenced by increased reactive oxygen species (ROS) level and malonyl dialdehyde (MDA) content, and decreased expression of glutathione peroxidase 4 (GPX4) after ADAMTS9-AS1 inhibition. Mechanistically, ADAMTS9-AS1 functioned as a competing endogenous RNA (ceRNA) via sponging miR-6516-5p to de-repress the expression of GPX4, the critical repressor of ferroptosis. Taken together, these results demonstrate that up-regulated ADAMTS9-AS1 accelerates ESCs proliferation and migration through regulating miR-6516-5p/GPX4-dependent ferroptosis, and may be a potential target for the treatment of EMs.
Study of the Correction Method of Secular Variation in the Main Geomagnetic Field by the Field Seismogeomagnetic Survey
Authors: su shupeng , Wang ZhaoJing , Liu Deqiang , Mao Fenglong 
Published: August 2021

Abstract
The correction of the secular variation (SV) of the main geomagnetic field is a key link of field seismogeomagnetic data processing, and the current method relies on the observatory data for the relevant technical processing. To optimize the data products and obtain more accurate and reliable seismomagnetic information, this study adopted a new technical idea, which uses the repeated survey data from field stations to obtain the SV of the main geomagnetic field over the survey area by the weighted least-squares method, and compared the results with those of the current methods. The results were as follows: 1. The SV results of the main geomagnetic field produced by the new method are closer to those of the International Geomagnetic Reference Field (IGRF)_SV model. The mean square error (MSE) of the difference of the three elements F, D, and I between the new method and the IGRF_SV model is 10.7%, 47.0%, and 14.5% of that of the original method, respectively. 2. By applying the new SV correction method, more stable and reasonable variations in Earth’s crustal magnetic field can be obtained. The average amplitude of the Earth’s crustal magnetic field variation in the three elements F, D, and I is 28.5%, 55.4%, and 34.4 of the original results, the MSE is 59.1%, 56.5%, and 40.3% of the original results, and the mean gradient is 93.6%, 91.9%, and 97.0%, respectively. 3. In the processed results of the new method, the seismomagnetic information is clearly optimized, and the location of the epicenter is more consistent with the 0 value line of the Earth’s crustal magnetic field. The processed results of the new method are significantly better than those of the original method and have a higher application value.
Identification of a Four-miRNA Signature Predicts Prognosis in Papillary Thyroid Cancer
Authors: FAN YANG , zhou Hongzhong 
Published: August 2021

Abstract
Background: In newly diagnosed patients with thyroid cancer, papillary thyroid cancer (PTC), accounts for ninety percent of all cases. Although PTC is known as a relatively adolescent malignant disease, there still is a high possibility of recurrence in PTC patients, who suffered from poor prognosis. Therefore, new biomarkers are necessary to guide more effective stratification of PTC patients and personalization of therapy to avoid overtreatment or inadequate treatment. Accumulating evidence demonstrates that miRNAs have broad application prospects as diagnostic biomarkers in cancer. Methods: The present study aims to explore novel markers consists of miRNA-associated signature for PTC prognostication, utilizing data from the TCGA database. We obtained and analyzed data of 497 PTC patients from the TCGA. The patients were randomly assigned to a training cohort or testing cohort. Results: We discovered 237 differentially expressed miRNAs in tumorous thyroid tissues comparing to normal tissues The effect evaluation of excavated differently expressed miRNAs was conducted by our risk score model. We then successfully generated a four-miRNA potential prognostic signature, which reliably distinguishes patients from high risk and low risk with a significant difference in overall survival (P <0.01) and was effective in predicting five-year disease survival. Conclusions: Our results indicated a four miRNAs signature that has a robust predicting effect on the prognosis of PTC. Therefore, we would recommend more radical treatment and closer follow-up of high-risk individuals.
Evaluation of Fetal Diaphragm Excursion and Thickness in Term Pregnancies Complicated With Pre-gestational and Gestational Diabetes Mellitus
Authors: Acmaz Gokhan , Ozdemir Fatma , Açmaz Banu , Madendag Yusuf , Madendag İlknur Çöl , Müderris İpek 
Published: August 2021

Abstract
Background: Both pre-gestational (PGDM) and gestational diabetes mellitus (GDM) make pregnancy complicated. Moreover in literature GDM and PGDM have been accused for respiratory morbidity in newborns. Diaphragm ultrasound (DUS) is useful and noninvasive method that provides an opportunity to examination of the diaphragmatic morphology and function. This study examined quality of fetal diaphragmatic contractions in pregnant women complicated with GDM and PGDM. Methods: A total of 105 volunteers separated into 3 groups; (1) GDM group (n=35), (2) PGDM group (n=35), and (3) healthy non-diabetic control group (n=35). Thickness of fetal diaphragm (DT), diaphragmatic excursion (DE), diaphragm thickening fraction (DTF) and costodiaphragmatic angle (CDA) was measured on the video frame during inspiration and expiration phases of respiration.Results: Especially PGDM group represented adversely affected diaphragm measurement parameters. DT inspiration, DT expiration, DE, CDA inspiration and DTF values were significantly different between PGDM and control group. Conclusions: Quality of fetal diaphragm movements affected in pregnancies complicated with GDM and PGDM. Prolonged duration of diabetes may have additional adverse effects on diaphragm morphology and its function.
Early Detection of Plant Virus Infection Using Multispectral Imaging and Spatial-Spectral Machine Learning
Authors: Peng Yao , Dallas Mary , Ascencio-Ibáñez José T. , Hoyer Steen , Legg James , Hanley-Bowdoin Linda , Grieve Bruce , Yin Hujun 
Published: August 2021

Abstract
Cassava brown streak disease (CBSD) is an emerging viral disease that can greatly reduce cassava productivity, while causing only mild aerial symptoms that develop late in infection. Early detection of CBSD enables better crop management and intervention. Current techniques require laboratory equipment and are labour intensive and often inaccurate. We have developed a handheld active multispectral imaging (A-MSI) device combined with machine learning for early detection of CBSD in real-time. The principal benefits of A-MSI over passive MSI and conventional camera systems are improved spectral signal-to-noise ratio and temporal repeatability. Information fusion techniques further combine spectral and spatial information to reliably identify features that distinguish healthy cassava from plants with CBSD as early as 28 days post inoculation. Application of the device has the potential to increase farmers' access to healthy planting materials and reduce losses due to CBSD in Africa. It can also be adapted for sensing other biotic and abiotic stresses in real-world situations where plants are exposed to multiple pest, pathogen and environmental stresses.
The Relationship Between Serum Orexin A, TGF-β, and Leptin Levels with Body Mass Index in Multiple Sclerosis Patients
Authors: Moharami Sepideh , Nourazarian Alireza , Nikanfar Masoud , Laghousi Delara , shademan behrouz , khaki-khatibi Fatemeh 
Published: August 2021

Abstract
Backgrounds: Multiple Sclerosis (MS) is a chronic inflammatory and autoimmune disease linked to several inflammatory and dietary parameters. This study was carried out to determine the relationship between serum leptin, orexin-A, and TGF-β levels with BMI in MS patients.Methods and results: In this cross-sectional study, 25 relapsing-remitting multiple sclerosis (RRMS) patients and 40 healthy controls were enrolled. The serum level of Leptin, Orexin-A, and TGF- were measured by the Enzyme-linked immunosorbent assay (ELISA). The data was analyzed using descriptive statistics, t-test, Chi-square test, and Linear regression test. A total of 65 volunteers, including 25 MS patients and 40 healthy, were enrolled in the study. The mean age of individuals in the case and control groups was 38.04 ± 7.53 and 40.23 ± 5.88. There were no statistically significant differences between the case and control groups regarding gender, age, alcohol, and cigarette use (P>0.05). The mean serum levels of Orexin-A and TGF-ß were lower among multiple sclerosis patients than in healthy controls, but leptin was higher (42.8 vs. 18.9 ng/ml, P<0.001). The relationship between BMI and serum levels of Orexin-A, TGF-ß, and Leptin among Multiple Sclerosis patients was not statistically significant (P > 0.05).Conclusion: Our results showed that the serum levels of Orexin-A and TGF-β were significantly lower. The serum level of leptin was higher among multiple sclerosis patients than among healthy controls. Also, there was no statistically significant relationship between BMI and serum levels of Orexin-A, TGF-ß, and Leptin among multiple sclerosis patients.
Emergence of KPC-2-Producing ST11-K64 Hypervirulent Klebsiella Pneumoniae for the Elderly in Intensive Care Unit: Antimicrobial Resistance, Molecular and Clinical Characteristics
Authors: Wei Tian , Zou Cheng-yun , Qin Jie , Tao Jian-min , Yan Li , Wang Jiang-jun , Du Hong , Shen Fang , Zhao Yan-qin , Wang Hai-ying 
Published: August 2021

Abstract
Background: In recent years, carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) has been increasingly reported and poses severe therapeutic challenge to global public health, but has not yet been systematically studied in elderly patients. This study aimed to investigate the clinical and molecular characteristics and risk factors of CR-hvKP infections in elderly patients. Methods: We retrospectively investigated elderly patients with carbapenem-resistant Klebsiella pneumoniae (CRKP) infections in intensive care unit (ICU),between January 2020 and December 2020, the clinical data being collected from medical records, and microbiological data including antimicrobial susceptibility testing, phenotype experiment, carbapenemases production, string test, virulence gene, capsular serotype-specific (cps) genes and multilocus sequence typing, of the CR-hvKP group defined by the presence of some combination of rmpA, rmpA2, iucA, iroB, and peg-344 was compared with those of carbapenem-resistant non-hypervirulent Klebsiella pneumoniae (CR-non-hvKP) strains.Results: Of 80 CRKP strains, 51(63.8%) met the definition of CR-hvKP and 7 of them had all five of the virulence genes tested. The main mechanism of resistance to carbapenems found in CR-hvKP strains was the presence of the blaKPC-2 gene. There was no statistical significance in the resistance rates of antimicrobial agents between the CR-hvKP and CR-non-hvKP subgroups (p ≥ 0.05). Compared with the minimum inhibitory concentration (MIC) 50 values of CR-non-hvKP group, those of antimicrobials, including ceftazidime, ceftazidime/avibactam, imipenem/avibactam, tigecycline, levofloxacin, cefoperazone-sulbactam, exhibited higher levels in the CR-hvKP group. Avibactam (4 µg/mL) significantly decreased the MIC90 values more than sixteen-fold than that of ceftazidime and imipenem alone against KPC-2-producing Klebsiella pneumoniae. K64 and ST11 were highly prevalent and strongly associated with CR-hvKP (P<0.05). Cardiovascular disease (odds ratio [OR] = 11.956) and ST11-K64 (OR= 8.385) appeared to be independent variables associated with CR-hvKP infection by multivariate analysis.Conclusion: The CR-hvKP strains showed higher MIC50 values than CR-non-hvKP strains. KPC-2-producing ST11-K64 CR-hvKP is emerging, which might become new significant “superbugs” and a threat to elderly patients.
The Efficacy and Safety of Treatment Regimens Used in the First-Line Setting in Metastatic Pancreatic Cancer Patients: A Multicenter Real-Life Study
Authors: Akdeniz Nadiye , Kaplan Muhammet Ali , İnanç Mevlüde , Uncu Doğan , Ergün Yakup , Küçüköner Mehmet , Demirci Ayşe , Şendur Mehmet Ali Nahit , Beşiroğlu Mehmet , Topçu Atakan , Yerlikaya Halis , Urakçı Zuhat , Kılıçkap Saadettin , Işıkdoğan Abdurrahman 
Published: August 2021

Abstract

Purpose: To compare the efficacy and toxicity of three different chemotherapy regimens used as first-line treatments in the real-life management of metastatic pancreatic cancer (mPC). Methods: A total of 218 patients diagnosed with mPC at the time of initial admission were included in this multicenter study. Gemcitabine (Gem, n=71), Gemcitabine-cisplatin (Gem-Cis, n=91) and FOLFIRINOX (FFX, n=56) treatments were compared in terms of efficacy and treatment-related toxicity. Results: Overall response rate was significantly higher in the FFX group (50.0%) than in the Gem (28.2%) and Gem-Cis (27.5%) groups (p=0.010).Median progression-free survival (8.4 vs. 4.6 and 5.5 months, respectively, p<0.001) and overall survival (16.4 vs. 8.1 and 8.7 months, respectively, p=0.002) were significantly longer in theFFX group than in the Gem and Gem-Cis groups. Toxicity of any grade was noted in 46(64.8%), 56(61.5%) and 49(87.5%) patients in the Gem, Gem-Cis and FFX groups, respectively (p=0.003).Of the grade 3-4 toxicities, weakness/fatigue and mucositis were reported only in the FFX group (5.4% and 3.6%, respectively). Grade 3-4 diarrhea (10.7%, 0.0%, 2.2%, respectively) and neutropenia (25%, 4.2% and 5.5%, respectively) were more common in the FFX group than in the Gem and Gem-Cis groups. Conclusion: In conclusion, our findings indicate that FFX regimen provides a significant advantage over the other treatment regimens in terms of response rates and survival. Treatment toxicity was more frequent but manageable with the FFX regimen.FFX seems to be a preferable regimen in the first-line treatment of the younger and fit patients diagnosed with mPC.
Stress, Pain, and Work Affiliation Are Strongly Associated With Health-related Quality of Life in Parents of 14–15-year-old Adolescents
Authors: Rohde Gudrun , Helseth Sølvi , Mikkelsen Hilde Timenes , Skarstein Siv , Småstuen Milada Cvancarova , Haraldstad Kristin 
Published: August 2021

Abstract
BackgroundFor many adults, their role as a parent is a vital part of their lives. This role is likely to be associated with a parent’s health-related quality of life (HRQOL). The aim of this study was to explore the associations between gender, demographic and psychosocial variables, and HRQOL pain in parents of 14–15-year-old adolescents.MethodsThis was a cross-sectional study that included 561 parents. Data on demographic, psychosocial variables and pain were collected using validated instruments. HRQOL was assessed using the RAND-36. Data were analysed using univariate and hierarchical multiple linear regression analyses.ResultsFour hundred and thirty-six (78%) mothers and 125 (22%) fathers with a mean age of 45 (SD = 5) years were included. Eighty-one per cent were married/cohabiting, 74% worked full time, and 50% had university education of more than 4 years. Almost one-third reported daily or weekly pain, and more than half (58%) reported using pain analgesics during the previous 4 weeks. Mothers reported significantly lower scores on self-efficacy, self-esteem and for all RAND-36 domains, including the physical component summary (PCS) and mental component summary (MCS) and experienced greater stress than fathers. Hierarchical regression analyses showed that working part-time (beta = 0.40) or full time (beta = 0.52) (reference: not working) had the strongest positive effect on PCS. Absence from work for >10 days (beta = –0.24) (reference: no absence), short-term pain (beta = –0.14), chronic pain (beta = –0.37) (reference: no pain), and stress (beta= –0.10) had the strongest negative effects on PCS. High self-esteem (beta = 0.11) had the strongest positive effect, whereas stress (beta = –0.58) and absence from work for >10 days (beta = –0.11) (reference: no absence) had the strongest negative effects on MCS.ConclusionMothers reported significantly lower scores on self-efficacy, self-esteem, and HRQOL, and experienced greater stress than the fathers. A high proportion of parents reported pain. Pain, stress, and low work affiliation were strongly associated with decreased HRQOL in parents. We recommend that parents of adolescents should be provided guidance about coping with pain and stress, and facilitation of a strong work affiliation because these seem to be important to parents’ HRQOL.
Evaluating the Direct Economic Burden of Prolonged Mechanical Ventilation Among Patients With Acute Type A Aortic Dissection: a Propensity Score-matched Cohort Analysis
Authors: Zhang Xu , Chen Liangwan , Peng Yanchun , Lin Yanjuan , Chen Qiong , Huang Xizhen , Li Sailan 
Published: August 2021

Abstract
Background: Prolonged mechanical ventilation (PMV) among acute type A aortic dissection (AAAD) may affect the prognosis, but poorly known about the direct economic burden of PMV in patients with AAAD. The present study was contributing to filling this knowledge gap.Methods: This present study was a retrospective cohort study. Age, gender, payment methods, and postoperative complications were matched at a 1:1 ratio by using a propensity score analysis of AAAD patients. The direct economic burden was expressed as the median 1:1 differences of various hospital costs and length of stay (LOS). The Wilcoxon signed-rank tests were used to compare the difference of direct economic burden at mechanical ventilation (MV) and PMV patients.Results: A total of 464 patients, PMV occurred in 142(30.6%) patients, and 218 patients were enrolled in the matched analysis. The estimated total direct economic burden of PMV was $4970.28(P<0.05). Among different hospital costs, western medicine ($3183.23) accounted for the highest category in the economic burden, followed by blood transfusion ($250.81) and materials fees ($207.43). The median hospital and Intensive Care Unit LOS in PMV groups were prolonged 5 days than those in MV groups (P < 0.05).Conclusions: Postoperative PMV was associated with increased economic burden among AAAD patients. This study emphasizes the need for early detection and management of PMV to reduce the economic burden.