bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-management advice, exercise and foot orthoses for plantar heel pain: the TREADON pilot and feasibility randomised trial
Authors: Chesterton Linda S. , Thomas Martin J. , Hendry Gordon , Chen Ying , Goddin David , Halliday Nicola , Lawton Sarah A. , Lewis Martyn , Mallen Christian D. , Menz Hylton B. , Foster Nadine E. , Roddy Edward 
Published: April 2021

Abstract
Background
Plantar heel pain (PHP) is common and impacts negatively on physical function and quality of life. Initial treatment usually comprises analgesia and self-management advice (SMA), with referral to a physiotherapist or podiatrist recommended only when symptoms persist. Systematic reviews highlight limitations of existing evidence for the effectiveness of exercises and orthoses. The objective of the TREADON pilot and feasibility trial was to inform the design of a future main trial to compare the clinical and cost-effectiveness of self-management advice (SMA), individualised exercises and foot orthoses for PHP.

Methods
This was a four-arm randomised feasibility and pilot trial with 12-week follow-up. Adults aged ≥ 18 years with PHP were identified from primary care by general practice consultation, retrospective general practice medical record review or a population survey. Participants were randomised to either (i) SMA, (ii) SMA plus individualised exercises (SMA-exercises), (iii) SMA plus prefabricated foot orthoses (SMA-orthoses) or (iv) SMA plus combined individualised exercises and prefabricated foot orthoses (SMA-combined). Feasibility outcomes were recruitment; retention; intervention adherence, credibility and satisfaction; performance of three potential primary outcome measures (pain numeric rating scale (NRS), Foot Function Index-pain subscale (FFI-pain), Manchester Foot Pain and Disability Index-pain subscale (MFPDI-pain)); and parameters for informing the main trial sample size calculation.

Results
Eighty-two participants were recruited. All three identification methods met the target number of participants. Retention at 12 weeks was 67%. All interventions were successfully delivered as per protocol. Adherence (range over 12 weeks 64–100%) and credibility (93%) were highest in the SMA-combined arm. Satisfaction with treatment was higher for the three clinician-supported interventions (SMA 29%, SMA-exercises 72%, SMA-orthoses 71%, SMA-combined 73%). Responsiveness (baseline to 12 weeks) was higher for FFI-pain (standardised response mean 0.96) and pain NRS (1.04) than MFPDI-pain (0.57). Conservative sample size parameter estimates for standard deviation were pain NRS 2.5, FFI-pain 25 and MFPDI-pain 4, and baseline-outcome correlations were 0.5–0.6, 0.4 and < 0.3, respectively.

Conclusions
We demonstrated the feasibility of conducting a future main randomised clinical trial comparing the clinical and cost-effectiveness of SMA, exercises and/or foot orthoses for PHP.

Trial registration number
ISRCTN 12160508. Prospectively registered 5th July 2016.
Natural bio-based monomers for biomedical applications: a review
Authors: Birajdar Mallinath S. , Joo Haejin , Koh Won-Gun , Park Hansoo 
Published: April 2021

Abstract
In recent years, synthetic and semi-synthetic polymer materials have been widely used in various applications. Especially concerning biomedical applications, their biocompatibility, biodegradability, and non-toxicity have increased the interest of researchers to discover and develop new products for the well-being of humanity. Among the synthetic and semi-synthetic materials, the use of natural bio-based monomeric materials presents a possible novel avenue for the development of new biocompatible, biodegradable, and non-toxic products. The purpose of this article is to review the information on the role of natural bio-based monomers in biomedical applications. Increased eco-friendliness, biocompatibility, biodegradability, non-toxicity, and intrinsic biological activity are some of the attributes which make itaconic, succinic, citric, hyaluronic, and glutamic acids suitable potential materials for biomedical applications. Herein, we summarize the most recent advances in the field over the past ten years and specifically highlight new and interesting discoveries in biomedical applications.

Graphical abstract
Natural origin acid-based bio-monomers for biomedical applications
The use of HEPES-buffer in the production of gallium-68 radiopharmaceuticals – time to reconsider strict pharmacopoeial limits?
Authors: le Roux Jannie , Kleynhans Janke , Rubow Sietske 
Published: April 2021

AbstractHEPES (4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid) is a buffer that is used in the radiolabelling of gallium-68 compounds. The beneficial effects of HEPES on molar activity in bioconjugates have been well described. Current strict regulations on the HEPES content in radiopharmaceuticals limit its use when intended for parenteral administration.This short communication summarizes data from the literature on the toxicity of HEPES in dogs after intravenous infusion and the subsequent use in humans. We also highlight the use of HEPES in an FDA labelled intravenous drug formulation. Regulatory institutions may consider this data to review current strict limits.
When experience does not promote expertise: security professionals fail to detect low prevalence fake IDs
Authors: Weatherford Dawn R. , Roberson Devin , Erickson William Blake 
Published: April 2021

AbstractProfessional screeners frequently verify photograph IDs in such industries as professional security, bar tending, and sales of age-restricted materials. Moreover, security screening is a vital tool for law enforcement in the search for missing or wanted persons. Nevertheless, previous research demonstrates that novice participants fail to spot fake IDs when they are rare (i.e., the low prevalence effect; LPE). To address whether this phenomenon also occurs with professional screeners, we conducted three experiments. Experiment 1 compared security professional and non-professionals. Experiment 2 compared bar-security professionals, access-security professionals, and non-professionals. Finally, Experiment 3 added a newly created Professional Identity Training Questionnaire to determine whether and how aspects of professionals’ employment predict ID-matching accuracy. Across all three experiments, all participants were susceptible to the LPE regardless of professional status. Neither length/type of professional experience nor length/type of training experience affected ID verification performance. We discuss task performance and survey responses with aims to acknowledge and address this potential problem in real-world screening scenarios.
What matters to children with lower limb deformities: an international qualitative study guiding the development of a new patient-reported outcome measure
Authors: Chhina Harpreet , Klassen Anne F. , Kopec Jacek A. , Oliffe John , Iobst Christopher , Dahan-Oliel Noemi , Aggarwal Aditya , Nunn Tim , Cooper Anthony P. 
Published: April 2021

Abstract
Background
Lower limb deformities include conditions such as leg length discrepancy, lower limb deficiency and associated angular and rotational deformities of the hips, knees, ankles and feet. Children with lower limb deformities often have physical limitations due to gait irregularities and pain. The differences in the appearance and function of their lower limbs can discourage participation in social, recreational and leisure activities, which may result in behavioural, emotional, psychological and social adjustment problems. The health-related quality of life (HRQL) of these children is often impacted due to the factors discussed above, as well as by the complex surgical procedures. Surgical treatment options for limb deformities in children vary from limb lengthening and reconstruction to amputation. The lack of evidence demonstrating superiority of either treatment options and their effect on HRQL limits the ability of healthcare providers to counsel families on the best evidence-based treatment option for them.
This manuscript describes the international qualitative study which guided the development of a new patient-reported outcome measure (PROM). Individual semi-structured face-to-face interviews with children with lower limb deformities and their parents were conducted at five sites: Canada (2 sites), Ethiopia, India and the USA.

Results
Seventy-nine interviews were conducted at five international sites. Five main themes emerged from the qualitative interviews and formed the basis of the conceptual framework. These themes were: 1) appearance, 2) physical health, 3) psychological health 4) school and 5) social health.

Conclusions
Lower limb deformities have a substantial impact on the HRQL of children. The concepts of interest identified in our study were similar across children from all countries. The conceptual framework guided the development of outcome scales specific to these patients.
The information about the impact of various treatment options on the HRQL of children with lower limb deformities, collected using this new PROM, could be used to inform parents and children about outcomes (physical, social, psychological) associated with specific treatment options. This information could supplement other objective outcome information (e.g., complication rates, how the leg will look, etc.) to help families to come to a more informed decision on a child’s course of treatment.
3D printing of graphene-based polymeric nanocomposites for biomedical applications
Authors: Silva Magda , Pinho Isabel S. , Covas José A. , Alves Natália M. , Paiva Maria C. 
Published: April 2021

AbstractAdditive manufacturing techniques established a new paradigm in the manufacture of composite materials providing a simple solution to build complex, custom designed shapes. In the biomedical field, 3D printing enabled the production of scaffolds with patient-specific requirements, controlling product architecture and microstructure, and have been proposed to regenerate a variety of tissues such as bone, cartilage, or the nervous system. Polymers reinforced with graphene or graphene derivatives have demonstrated potential interest for applications that require electrical and mechanical properties as well as enhanced cell response, presenting increasing interest for applications in the biomedical field. The present review focuses on graphene-based polymer nanocomposites developed for additive manufacturing fabrication, provides an overview of the manufacturing techniques available to reach the different biomedical applications, and summarizes relevant results obtained with 3D printed graphene/polymer scaffolds and biosensors.
Using urinary neutrophile gelatinase-associated lipocalin for prognosticate renal dysfunction in children with familial Mediterranean fever the study design: a pilot study
Authors: Oksay Sinem Can , Dursun Hasan , Neijmann Sebnem Tekin , Hatipoglu Sami 
Published: April 2021

Abstract
Background
The most important finding that affects the prognosis in Familial Mediterranean Fever is renal amyloidosis. The aim of the present study was to analyze neutrophil gelatinase-associated lipocalin levels in the urine, and to investigate whether it may be used as an early marker for renal involvement.

Methods
Forty attack-free children followed by diagnosis of Familial Mediterranean Fever with age range of 5 and 18 years, and 38 healthy children with similar ages and genders were enrolled into the study. Hemogram, sedimentation, C-reactive protein, urine analysis, creatinine in the spot urine, microalbumin and urinary neutrophil gelatinase-associated lipocalin levels were analyzed and evaluated statistically in the patients and controls.

Results
There was not any statistically significant difference between the patient and control groups for age, gender, height and body weight. Although there was not any clinical sign of attack in the patient group, sedimentation, C-reactive protein and fibrinogen levels were significantly higher than the control group (p = 0.002, p = 0.023, and p = 0.006, respectively). Similarly, urinary neutrophil gelatinase-associated lipocalin level and urinary creatinine ratio were significantly higher in the patient group (p = 0.0001, p = 0.011, respectively). We found a positive correlation between uNGAL level and uNGAL/uCr ratio and number of attacks per year in FMF patients (r = 0.743, p = 0.001 and r = 0.516, p = 0.001; respectively).

Conclusions
Detection of significantly higher levels of urinary neutrophil gelatinase-associated lipocalin level and urinary neutrophil gelatinase-associated lipocalin level to creatinine ratio were suggested as urinary neutrophil gelatinase-associated lipocalin level as a non-invasive marker for renal involvement better than microalbumin.
Levator palpabrae superioris myositis as an unusual cause of unilateral ptosis—case report
Authors: Abdrabou Ahmed M. 
Published: April 2021

Abstract
Background
Ptosis can be a manifestation of a more serious situation. Hence, the analysis of the complaint and the search for etiology are crucial in such cases. Ptosis has many causes; some of them lead to unilateral ptosis while others cause bilateral ptosis. For instance, myasthenia gravis is a cause of bilateral ptosis while oculomotor nerve palsy induces unilateral disease. Proper evaluation of the patient and identification of the cause are important to achieve accurate management and good prognosis.

Case presentation
A 47-year-old male patient attended the ER complaining of dropping the right eye lid of 2 days’ duration. There was no associated pain or diplopia. On examination, the extraocular muscles’ (EOM) motility was intact, normal pupil and corneal reflexes, and there was swelling of the upper eyelid. Ophthalmological examination revealed normal anterior and posterior chambers as well as the vitreous and retina. The patient had a previous history of traumatic intracranial hemorrhage that was resolved without surgical intervention. He also had diabetes mellitus and hypertension. The patient was transferred to the MRI unit to perform MRI study of the brain and orbit with MRA and IV contrast administration. MRI findings confirmed the diagnosis of LPS myositis, and the patient received medical treatment and improved.

Conclusion
Proper radiological diagnosis leads to accurate management and achieves rapid recovery and optimal patient care.
Episodic Spontaneous Dizziness
Authors: Eggers Scott D. Z. 
Published: April 2021

ABSTRACT

PURPOSE OF REVIEW
Conditions causing recurrent spontaneous episodes of dizziness or vertigo span several medical specialties, making it challenging for clinicians to gain confidence in evaluating and managing the spectrum of episodic vestibular disorders. Patients are often asymptomatic and have normal examinations at the time of evaluation. Thus, diagnosis depends heavily on eliciting key features from the history. Overreliance on symptom quality descriptions commonly leads to misdiagnosis. The goal of this article is to provide the reader with a straightforward approach to the diagnosis and management of conditions that cause episodic spontaneous dizziness.

RECENT FINDINGS
Consensus diagnostic criteria have been established for vestibular migraine, Ménière disease, vestibular paroxysmia, and hemodynamic orthostatic dizziness/vertigo. Vertigo has been recognized as a common symptom in vertebrobasilar ischemia, cardiogenic dizziness, and orthostatic hypotension. Treatment recommendations for vestibular migraine still lack high-quality evidence, but controlled trials are occurring.

SUMMARY
The evaluation should start with a detailed description of the episodes from the patient and any observers. Rather than focusing first on whether the symptom quality is most consistent with vertigo, dizziness, lightheadedness, or unsteadiness, the clinician should clarify the timing (episode frequency and duration), possible triggers or circumstances (eg, position changes, upright posture), and accompanying symptoms. History should identify any auditory symptoms, migraine features, posterior circulation ischemic symptoms, vascular risk factors, clues for anxiety, and potentially relevant medications. Carefully selected testing can help secure the diagnosis, but excessive and indiscriminate testing can lead to more confusion. Treatments for these conditions are vastly different, so an accurate diagnosis is critical.
Vestibular Testing
Authors: Hain Timothy C. , Cherchi Marcello 
Published: April 2021

ABSTRACT

PURPOSE OF REVIEW
Vestibular testing, both at the bedside and in the laboratory, is often critical in diagnosing patients with symptoms of vertigo, dizziness, unsteadiness, and oscillopsia. This article introduces readers to core concepts, as well as recent advances, in bedside and instrumented vestibular assessments.

RECENT FINDINGS
Vestibular testing has improved immensely in the past 2 decades. While history and bedside testing is still the primary method of differential diagnosis in patients with dizziness, advances in technology such as the ocular vestibular-evoked myogenic potential test for superior canal dehiscence and the video head impulse test for vestibular neuritis have capabilities that go far beyond the bedside examination. Current vestibular testing now allows clinicians to test all five vestibular sensors in the inner ear.

SUMMARY
Contemporary vestibular testing technology can now assess the entire vestibular periphery. Relatively subtle conditions, such as superior canal dehiscence or a subtle vestibular neuritis, can now be diagnosed with far greater certainty.
Musculoskeletal and Sports Medicine Curriculum Guidelines for Pediatric Residents
Authors: Coleman Nailah , Beasley Michael , Briskin Susannah , Chapman Michael , Cuff Steven , Demorest Rebecca A. , Halstead Mark , Hornbeck Kimberly , Kinsella Sarah B. , Logan Kelsey , Liu Ruikang , Mooney Caitlyn , Myers Rebecca A. , Ruparell Sonia , Santana Jonathan , Walter Kevin D. , Waterbrook Anna L. , Wolf Sigrid F. 
Published: April 2021

Abstract
Musculoskeletal (MSK) and sports-related conditions are relatively common in the pediatric population. Pediatric residencies should provide residents with the knowledge and skills to assess and manage both acute and chronic MSK and sports injuries and complaints. Residents should develop the competencies and attitudes to safeguard and promote a healthy and active lifestyle for youth. Programs can use a variety of educational tools, both in the clinic and on the field, to provide a well-rounded MSK curriculum throughout the residency years. This article provides a review of general pediatric sports medicine curriculum guidelines and suggested implementation strategies.
RETRACTED: Potential effects of elevated temperature on seasonal movements in slipper lobsters, Scyllarides latus (Latreille, 1803), in the eastern Mediterranean
Authors: GOLDSTEIN JASON , SPANIER EHUD 
Published: April 2021

Retraction of: Mediterranean Marine Science http://dx.doi.org/10.12681/mms.22074, published online 13 July 2020Editor note: The authors are retracting this article.In the article, Potential effects of elevated temperature on seasonal movements in slipper lobsters, Scyllarides latus (Latreille, 1803), in the eastern Mediterranean (Vol. 21, 2020, https://doi.org/10.12681/mms.22074), authors J. Goldstein and E. Spanier have made an honest error in the inaccurate interpretation of their special scientific permit that afforded them the opportunity to collect wild-caught animals in the field and release them in their study area, in the marine reserve where this work was conducted. More specifically, the study component that refers to the ‘field tagging study’, was carried out without the full scope of permitting guidance unbeknownst to the authors. Dr. R. Yahel and E. Miller, Marine Ecologists of the Israeli National Park Authority (INPA), have pointed this out and have since requested that the article be removed given that the application of the special use permit was misinterpreted and not exercised in an appropriate manner. The authors were also not able to forward the INPA with the field’s raw data that have been lost since this field study was carried out over eight years ago. The authors were not aware of this discrepancy at the time the field study was carried out, but they have agreed to remove the article out of respect and admiration of the INPA and the continued protection and conservation of the Mediterranean slipper lobster in coastal Israeli waters. However, this action of retraction does not change the overall outcome of the paper’s finding including the study design, analyses, scientific integrity, or overall conclusions. The authors will plan on publishing the laboratory-based portion of this study as a stand-alone manuscript at a future date.
A survey on the occurrence of Brachyspira pilosicoli and Brachyspira hyodysenteriae in growing-finishing pigs
Authors: Dors Arkadiusz , Czyżewska-Dors Ewelina , Woźniakowski Grzegorz 
Published: April 2021

Background: The major pathogenic intestinal spirochetes affecting pigs during the growing- finishing stage of production includeBrachyspira hyodysenteriaeandBrachyspira pilosicoli. The aim of this study was to assess the current occurrence ofB. hyodysenteriaeandB. pilosicoliin Polish pig herds. Moreover, associations between the presence of diarrhea or other intestinal pathogens and occurrence ofB. hyodysenteriaeandB. pilosicoliin pigs were investigated.Methods: Between January 2017 and August 2019, a total of 401 samples of pig feces from 95 different herds were submitted to the National Veterinary Research Institute of Poland. These samples were obtained from pigs older than 7 weeks. All the received fecal samples were examined for the presence ofB. hyodysenteriae,B. pilosicoliandLawsonia intracellularisby real-time PCR.Results:B. pilosicoliwas detected in 4.5% (95% CI, 2.5–7.0%) (18/401) of pig fecal samples. At the herd level 13.7% (95% CI, 7.5–22.3%) (13/95) of herds were positive forB. pilosicoli.B. hyodysenteriaewas detected in 7.0% (95% CI, 4.7–9.9%) (28/401) of pig fecal samples and 18.9% (95% CI, 11.6–28.3%) (18/95) of pig herds were positive. Out of 18B. pilosicolipositive samples, this pathogen was detected alone in 5 samples; simultaneously withL. intracellularisin 9 samples; simultaneously withB. hyodysenteriaein 1 sample and in 3 samples was detected simultaneously with both of these bacteria. The presence ofB. hyodysenteriaein fecal samples was associated with the presence of diarrhea in pigs.Conclusions: This study confirmed thatB. pilosicoliinfections occur in Polish pig herds, but the prevalence is at a low level and the presence ofB. pilosicoliis not associated with the development of diarrhea in pigs.B. hyodysenteriaeis still a common cause of diarrhea among pigs from Polish herds.