bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research Progress of Nanostructured Lipid Carriers in Ocular Drug Delivery
Authors: Chakole Chandrashekhar Mahadeo , Chauhan Meenakshi Kanwar 
Published: February 2021

:
The eye is the most important sensory organ, which restricts most of the active substances
due to its static and dynamic barriers. The application of conventional eye drop is still popular,
but it was found to be less permeable to both anterior and posterior eye portions, requiring
more frequent administration. It seems to be a great challenge for the researcher to fabricate an ocular
formulation that crosses the barriers and achieves an optimal therapeutic concentration at the ocular
globe. Recent studies revealed that a nanostructured lipid carrier has great potential in ophthalmic
use and has become more popular due to its permeability in the eye cavity.

:
This review describes the nanostructured lipid carriers with respect to the mechanism of ocular
permeation, structural feature, manufacturing process, characterization, and its merits over other
nanocarriers. In recent years, newly nanostructured-based ocular formulations have been developed,
like surface-modified with various cationic compounds and their integration with different
polymeric systems, to enhance ocular bioavailability in both regions of the eye. Newly developed
nanostructured lipid carriers include surface modified cationic lipid, polymers, and thiolated compounds,
etc., that increases mucoadhesive property. Finally, nanostructured incorporated forms, in
situ gel, and hydrogel increase permeation in the posterior region of the eye.
Mobile Apps to Support Family Caregivers of People With Alzheimer Disease and Related Dementias in Managing Disruptive Behaviors: Qualitative Study With Users Embedded in a Scoping Review
Authors: Désormeaux-Moreau Marjorie , Michel Charlie-Maude , Vallières Mélanie , Racine Maryse , Poulin-Paquet Myriame , Lacasse Delphine , Gionet Pascale , Genereux Melissa , Lachiheb Wael , Provencher Véronique 
Published: February 2021

Background
People with Alzheimer disease and related dementias often display disruptive behaviors (eg, aggression, wandering, and restlessness), which increase family caregivers’ burden of care. However, there are few tools currently available to help these caregivers manage disruptive behaviors. Mobile apps could meet this need, but to date little is known about them.

Objective
The aims of our study were to identify existing mobile apps designed to support family caregivers of people with Alzheimer disease and related dementias in managing disruptive behaviors; explore whether family caregivers view these mobile apps as relevant to meeting their needs and as useful in managing disruptive behaviors; and document the types of mobile apps that are of interest and appeal to most family caregivers (with regard to format, ergonomics, and clarity).

Methods
A review of mobile apps initially conducted in February 2018 was updated in March 2019 with 2 platforms (App Store [Apple Inc.] and Google Play [Google]). The selected apps were first analyzed independently by 3 raters (2 students and 1 researcher) for each of the platforms. A focus group discussion was then held with 4 family caregivers to explore their perceptions of the apps according to their needs and interests. The content of the discussion was analyzed.

Results
Initially, 7 of 118 apps identified met the inclusion criteria. An eighth app, recommended by one of the knowledge users, was added later. Four family caregivers (women aged between 58 and 78 years) participated in the discussion. Participants expressed a preference for easy-to-understand apps that provide concrete intervention strategies. They reported being most inclined to use two apps, Dementia Advisor and DTA Behaviours.

Conclusions
Few mobile apps on the market meet the needs of family caregivers in terms of content and usability. Our results could help to address this gap by identifying what family caregivers deem relevant in a mobile app to help them manage disruptive behaviors.
Effectiveness of Mobile Health–Based Exercise Interventions for Patients with Peripheral Artery Disease: Systematic Review and Meta-Analysis
Authors: Kim Mihui , Kim Changhwan , Kim Eunkyo , Choi Mona 
Published: February 2021

Background
Peripheral artery disease (PAD) affects over 236 million people worldwide, and exercise interventions are commonly used to alleviate symptoms of this condition. However, no previous systematic review has evaluated the effects of mobile health (mHealth)–based exercise interventions for patients with PAD.

Objective
This study aimed to assess the effect of mHealth-based exercise interventions on walking performance, functional status, and quality of life in patients with PAD.

Methods
A systematic review and meta-analysis were conducted. We searched in seven databases to identify randomized controlled trials of patients with PAD published in English up to December 4, 2020. Studies were included if patients participated in mHealth-based exercise interventions and were assessed for walking performance. We analyzed pooled effect size on walking performance, functional status, and quality of life based on the standardized mean differences between groups.

Results
A total of seven studies were selected for the systematic review, and six studies were included in the meta-analysis. The duration of interventions in the included studies was 12 to 48 weeks. In the pooled analysis, when compared with the control groups, the mHealth-based exercise intervention groups were associated with significant improvements in pain-free walking (95% CI 0.13-0.88), maximal walking (95% CI 0.03-0.87), 6-minute walk test (6MWT) distance (95% CI 0.59-1.24), and walking distance (95% CI 0.02-0.49). However, benefits of the interventions on walking speed, stair-climbing ability, and quality of life were not observed.

Conclusions
mHealth-based exercise interventions for patients with PAD were beneficial for improving pain-free walking, maximal walking, and 6MWT distance. We found that exercise interventions using mHealth are an important strategy for improving the exercise effectiveness and adherence rate of patients with PAD. Future studies should consider the use of various and suitable functions of mHealth that can increase the adherence rates and improve the effectiveness of exercise.
Association between Matrix Metalloproteinas-2 Gene Variants and Pathogenesis of Breast Cancer in Sera of Iraqi Women
Authors: Abbas Yammamah Jawad , Al-Tu'ma Fadhil Jawad , Al-Hemerri Alaa Fraq 
Published: February 2021

Objective: The current study aims to investigate the role of MMP-2 in breast cancer pathogenesis in Iraqi women.
Methods: A forty one women with breast cancer and 45 control women were included in this case-control study. Body mass index, age, smoking; married status, tumor size, degree, subtype, lymph node status, pre and postmenopesua included the phenotypic results. The polymerase chain reaction-PCR-allele specific restriction was used to observe the rs243865 polymorphism. Genomic DNA was extracted from whole blood and genotyping with specific prefixes for amplification of the MMP-2 gene was accomplished as enzyme-restricted PCR products were digested, followed by electrophoresis on 1.5% agarose gel. In order to interpret the researchers' results, numerous statistical analyses were applied.
Results: The amplicon size of MMP-2 gene was 304 bp, and following its amplification reactions by allelic specific PCR. The amplification product for MMP-2 gene amplification SNP rs243865 gene polymorphism results exhibited one band of 304 bp, two bands of 304 bp and one band 304 bp for individuals have genotype as wild type (CC), homozygous (TT) and heterozygous (CT), respectively. Genotype frequencies of rs243865 polymorphism were found to be consistent with Hardyâ€“Weinberg equilibrium. Allele frequencies of C allele was 0.57, and the T allele was only 0.43 in cases of breast cancer women patient, while the frequencies of CC, CT, and TT genotypes of the rs243865 SNP were statistically significant as 31.7%, 51.2%, 17.1% respectively. Allele frequencies of C and T were 0.78 and 0.22 for the control group, respectively, the heterozygous genotype (CT) was significantly increased the risk of breast cancer women (OR=0.3, 95% CI;0.12 â€“ 0.8 , Pâ‰¤ 0.05) with respect to those of the CC wild type. The TT genotype significantly raised the risk of breast cancer women by (OR = 0.2, 95% CI; 0.04 â€“ 0.9, Pâ‰¤ 0.05).
Conclusion: In women with breast cancer, MMP-2 expression is highly association were observed with positive lymph node, histological classification of breast cancer (ll) higher than other classes, and advanced clinical process (ll).
THE WONDER FOOD MUSEUM STORY: CELEBRATING MALAYSIA’S FOOD CULTURE AND CULINARY HERITAGE
Authors: SER ShawHong 
Published: February 2021

Although thematic museums centered around food culture and culinary heritage have beenaround for decades, the concept of food museum is still fairly new in Southeast Asia. Only in2015, the first food-oriented museum – “Wonder Food Museum” was established in Penang,Malaysia. Since its establishment, the museum has received positive feedback from bothlocal and international visitors. From 2017 to 2019, the museum has been selected as therecipient of the Certificate of Excellence by international well renowned Travel organization -TripAdvisor Inc. Meanwhile, the museum’s contribution to the state’s cultural and tourismdevelopment has also been recognized by the state authority. In 2017 and 2019, the museumwas awarded the ‘Top Museum Award (Unique Concept)’, and ‘Best Tourism(Museum)Award’ by the INPenang International Awards respectively. By and large, WonderFood Museum is currently one of the most outstanding museums in Malaysia and a wellknownattraction in Penang. In this paper, to response on the research scholarly interest inmuseum tourism in Southeast Asia, the researcher has made an attempt to document thedevelopment of Wonder Food Museum from 2015 to 2019. The museum’s curatorial concept,exhibits production, exhibition planning and its overall management will be discussed andanalyzed. As the aforementioned this paper will provide insights into an understanding of foodmuseum’s development in Malaysia.
Keywords: Food museum, food culture, culinary heritage, Malaysia’s museum, museumtourism, interactive museum
The influence of the preoperative rehabilitation on the results of anatomical lung resections
Authors: Romanikhin A. I. , Gorbunkov S. D. , Kovalev M. G. , Akopov A. L. 
Published: February 2021

The objective was to investigate the efficiency of the preoperative rehabilitation for patients with planned anatomical lung resections.Methods and materials.The study included 92 patients aged 27 to 87 years (mean age (63±10.8) years), 25 women (27.2 %) and 67 men (72.8 %) who underwent anatomical lung resections (79 patients, 85.9 % for lung cancer). Group 1 (39 patients – 42 %) included patients who did not smoke or quitted smoking at least 2 months before the operation. Also, they complied with the recommendations regarding respiratory gymnastics and the use of exercise and induction spirometers in full for at least 14 days. All patients who continued smoking or abandoned it less than 2 weeks before the operation, did not use breathing exercises, were included in group 2 (53 patients – 58 %).Results. Significant difference was found in the number of complications in the studied groups (the average number of complications in one patient in group 1 was (0.46±0.8), in group 2 – (1.47±1.5), p = 0.03). The difference was found in the duration of hospitalization (19.7 days in group 1 and 25.3 days in group 2, p <0.017), in the length of stay in the ICU ((1.6±0.9) days in group 1 versus (3.4±5.9) days in group 2, p = 0.011). The early postoperative period for patients of group 1 was more favorable regardless of the presence and severity of the course of concomitant chronic obstructive pulmonary disease.Conclusions. Comprehensive preoperative rehabilitation helps to reduce the number and severity of manifestations of complications after anatomical lung resections.
Assessment of the physical, social and value component of health in the structure of healthy lifestyle among the student youth of medical university
Authors: Arkhipova L. Yu. , Svishcheva A. A. 
Published: February 2021

Introduction. Young people act as a basic component of the security of society. Physical development data is an indicator of the level of health of the population. Studying at the university coincides with the reproductive period. Adverse effects on the body of young people during this period can negatively affect the health of the next generation. Physical culture and sports activities allow students to integrate effectively into the educational space of the university.The objective of our study was to assess the morphological and medical and social characteristics of the physical development of the student youth in Saratov.Methods and materials. The study was conducted in 2018–2019 at the base of the department of physical therapy, sports medicine and physiotherapy in Saratov State Medical University named after V. I. Razumovsky. Respondents were the students of the Saratov State Medical University named after V. I. Razumovsky as the most promising group of young people in the preservation of reproductive health. Anthropometric parameters were carried out in accordance with the recommendations of V. V. Bunak. The study included anthropometric parameters: body weight, body length, and mass-growth correlation. We analyzed the values of the method «Diagnosing the real structure of value orientations». Analysis of self assessment of the level of health and assessment of their healthy lifestyle by the author’s questionnaire of a closed type.Results. Data of anthropometric parameters of physical development and body mass index of boys 2018–2019 tends to be overweight. S.S. Bubnova’s most preferred values for medical students are «help and mercy for people», «recognition and respect for others» and «pleasant pastime» that does not correlate with health care. Analysis of value priorities in the healthy lifestyle of medical students showed that the majority of respondents to health is not quite high role.Conclusion. Motivated preservation of individual health and active position of the university in the case of healthy lifestyle during the student studies can have a beneficial effect in the formation of health behavior of young people. It is necessary to establish the possibility of regular, accessible and balanced nutrition of students during the study at the university.
Gastrointestinal symptoms as an indicator of progression of pulmonary involvement in patients with COVID-19
Authors: Altunisik Erman , Baykan Ali Haydar , Sayiner Hakan Sezgin , Erturk Mehmet Sukru 
Published: February 2021

Background:
While the patients with coronavirus disease 2019 typically present with respiratory illness, some patients also report gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain. In this case study, four different cases with the progression of pulmonary computed tomography (CT) findings following the onset of gastrointestinal symptoms are presented.

Case presentation:
Case 1, A 37-year-old male patient presented with fever, cough, fatigue, muscle and joint pain. On the fifth day of treatment, gastrointestinal symptoms including anorexia, nausea and vomiting were observed. A follow-up chest CT revealed progression in pulmonary involvement. Case 2, A 46-year-old male patient presented with fever, shortness of breath, muscle and joint pain. On the fourth day of treatment, gastrointestinal symptoms including anorexia, nausea and vomiting were observed. A follow-up chest CT revealed progression of pulmonary findings in both lungs. Case 3, A 50-year-old male presented with no symptoms other than dry cough. On the fourth day of treatment, gastrointestinal symptoms including anorexia, nausea and vomiting were observed. A follow-up chest CT revealed bilateral peripherally ground-glass and consolidation areas. Case 4, A 34-year-old female patient presented with fever, cough, fatigue, muscle and joint pain. On the third day of the treatment, gastrointestinal symptoms including anorexia, nausea, vomiting and diarrhea were observed. A follow-up chest CT revealed bilateral progression of pulmonary findings.

Conclusion:
Many studies reported that patients with gastrointestinal symptoms have a more serious clinical course than patients without these symptoms. No study has yet been presented to the literature in which this clinical situation is supported by radiological findings.
COMPARISON OF WIRELESS NETWORK OVER WIRED NETWORK AND ITS TYPE
Authors: Shukla Shikha , K M Meghana , C R Manjunath , Naik Santosh 
Published: February 2021

Wireless network has become one of the major requirements in today world. People expect wireless network in home, shopping mall, university etc. Nowadays, we cannot imagine the life without network. In this paper focuses on what the different types of networks are. Why wired network is preferred over wireless network. We will further compare the wired network with the wireless network and also present different type of wireless network. This paper provides the basic knowledge about Wired, Wireless, Wireless LAN, and WIMAX network. Comparison between wired and wireless has been performed with respect to different factor such as Reliability, Visibility, installation etc. Comparison proves that wireless network is better than wired network when compared with respect to mobility, Cost, Reliability.
ENHANCEMENT OF ELECTRICAL CONDUCTIVITY IN POLYVINYL ALCOHOL FILMS BY DOPING WITH Nd3+IONS
Authors: Kumar Vijaya 
Published: February 2021

The electrical properties of polyvinyl alcohol (PVA) films have been improved pronouncedly by doping with Neodymium (III) nitrate hexahydrate. Pure PVA and PVA: Nd3+ films have been prepared by solution casting method. Both type of films were characterized by X-ray diffraction technique for structural studies. XRD pattern shows the appreciable shift of 2Ө towards higher value with increase in Nd3+ concentration. This signifies the presence Nd3+ dopant in polymer matrix. Further direct current electrical conductivity (σ) of Nd3+ doped PVA films in the temperature range 500C-1600C has been studied using four probe techniques. For a given concentration σ increases with increase in temperature and with dopant concentration. At 1200C, conductivity of PVA: Nd3+ (10 mol %) film is 7.116 μΩ-1cm-1, PVA: Nd3+ (15 mol %) film is 11.176 μΩ-1cm-1, PVA: Nd3+ (20 mol %) film is 17.418 μΩ-1cm-1 and PVA: Nd3+ (25 mol %) film is 23.740 μΩ-1cm-1. This result indicated the enhancement of the electrical conductivity of PVA films with Nd3+ concentration.
PENGARUH MEKANISME GOOD CORPORATE GOVERNANCE TERHADAP PRAKTIK MANAJEMEN LABA
Authors: Wahyuwidi Syafira Fitri , Lusmeida Herlina 
Published: February 2021

Penelitian ini bertujuan untuk menganalisis dan memberikan bukti secara empiris mengenai pengaruh antara mekanisme good corporate governance yang diproksikan dengan proporsi dewan komisaris independen, jumlah dewan direksi, kepemilikan manajerial, kepemilikan institusional dan kualitas audit terhadap praktik manajemen laba. Penelitian ini menggunakan 39 sampel perusahaan manufaktur sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia selama periode 2016 sampai dengan 2019 yang dipilih dengan menggunakan purposive sampling method, sehingga didapatkan 140 data observasi. Pengolahan data dilakukan dengan menggunakan analisis regresi berganda. Hasil penelitian ini mengindikasikan bahwa proporsi dewan komisaris independen, kepemilikan manajerial, dan kualitas audit berpengaruh secara negatif dan signifikan terhadap manajemen laba. Sedangkan kepemilikan institusional berpengaruh secara positif dan signifikan terhadap manajemen laba, dan jumlah dewan direksi tidak berpengaruh secara signifikan terhadap manajemen laba.
Kata kunci: Discretionary accruals, good corporate governance, manajemen laba.
Prawne ramy pracy zdalnej
Authors: Florek Ludwik 
Published: February 2021

Wraz z pandemią koronawirusa szeroko wprowadzono pracę zdalną, odrębną od telepracy. W obydwu przypadkach jest to praca poza stałym miejscem pracy, najczęściej w mieszkaniu pracownika. Prawne ramy pracy zdalnej są takie same jak telepracy. Jest to przede wszystkim umowa o pracę, z reguły zawarta przed pandemią. Praca zdalna może łączyć się ze zmianą innych (poza miejscem pracy) postanowień umowy, jak rozmiar zatrudnienia, czas pracy czy wysokość wynagrodzenia. Pracę zdalną regulują – oprócz umowy – także przepisy prawa pracy, w tym zwłaszcza art. 675–art. 6717 polskiego kodeksu pracy. Praca zdalna jest wykonywana na podstawie stosunku pracy. Jej przeniesienie poza zakład pracy powoduje także modyfikację tradycyjnych cech tego stosunku. W szczególności może to dotyczyć podporządkowania pracownika, osobistego świadczenia pracy, zapewnienia narzędzi pracy, ryzyka pracodawcy czy odpowiedzialności pracownika.
An Analysis of Actors in the Implementation of Public Policy on Accessibility of Persons with Disabilities for Work in Indonesia’s Special Region Yogyakarta
Authors: Maulana Muhammad Akbar , Rahmawati Dian Eka , Nurmandi Achmad 
Published: February 2021

This study aims to analyze the implementation of public policy on the accessibility of persons with disabilities to get a job in Yogyakarta. It focuses on the actors implementing the policy in the Indonesian region, namely the provincial government of Yogyakarta as the implementer and policymaker, private companies, and Non-Government Organization (NGOs), which should be the stakeholders of the policy, program, and activities in distributing labors with disabilities. To approach this problem, the researchers use the theory of Van Meter and Horn as a reference. Data have been collected through interviews and documentation that later on analyzed qualitatively with the software of NVivo 12 plus. This study concludes that providing employment opportunities for persons with disabilities has not been implemented optimally. First, it is due to the absence of aftercare services, namely follow-up assistance for persons with disabilities after participating in training and rehabilitation programs held by the Regional Government. Secondly, law enforcement in the policy implementation that is pro disabilities (inclusion) to private companies is not optimal. Third, the lack of coordination among the actors in the efforts of empowering persons with disabilities.