bluuebunny/crossref_metadata_2025_split huggingface dataset:
TÜRK YUNAN İLİŞKİLERİNDE KISA ÖMÜRLÜ BİR GİRİŞİM: TÜRK-ELLEN DOSTLUK DERNEĞİ (1952)
Authors: ORAKÇI Meryem 
Published: June 2021

Atatürk-Venizelos öncülüğünde Türkiye ve Yunanistan arasında kurulan iyi ilişkiler II. Dünya Savaşıyla kesintiye uğramıştır. Savaş sırasında işgal edilen, sonrasında ise iç savaş yaşayan Yunanistan Batı bloğuna yaklaşmıştır. Türkiye de Sovyet tehdidi ve ekonomik kaygılarla kendisine aynı blok içerisinde yer bulmaya çalışmıştır. Ortak kaygılar ve hedefler iki ülkeyi yaklaşık on yıl sonra tekrar birbirine yaklaştırmıştır. İsmet İnönü’nün Cumhurbaşkanlığında başlayan bu yakınlaşma, Türkiye’deki iktidarın değişmesiyle birlikte ivme kazanmıştır. NATO’ya giriş için benzer çabalar gösteren iki ülke, 1950 yılında başlayan Demokrat Parti döneminin özellikle ilk yarısında iyi ilişkileri zirveye taşımıştır. Birçok alanda işbirliği içerisine girilmesinin yanı sıra, karşılıklı olarak üst düzey resmi ziyaretler gerçekleştirilmiştir. Yunanistan’a giden Cumhurbaşkanı Celal Bayar, Başbakan Adnan Menderes, Dışişleri Bakanı Fuat Köprülü’ye karşılık; Yunan Dışişleri Bakanı Sofokles Venizelos ve Yunan Kralı Pavlos Türkiye’ye gelmişlerdir.
Kuruluşu 1930’lara dayanan ve Atina’da bulunan Türk-Yunan Birliği bu resmi ziyaretlerde ön plana çıkmıştır. 1952 yılında Türk tarafında da bu dernekle eşgüdümlü çalışacak bir Türk Yunan Dostluk Derneği kurulması gündeme gelmiş ve hızlı bir şekilde hayata geçirilmiştir. Türk-Ellen Dostluk Derneğinin başkanının İstanbul Valisi ve Belediye Başkanı Fahrettin Kerim Gökay olması, kuruluş aşamasında bu girişime büyük bir önem verildiğini göstermektedir. Üyeleri ise siyaset, ekonomi ve sanat dünyasından Türk ve Yunan uyruklu önemli şahsiyetler olmuştur. Bu kadrosuna rağmen 1952 yılı boyunca sadece resmi ziyaretlerin karşılama-uğurlama gibi kısımlarında görünür olan dernek, Kıbrıs gerilimiyle birlikte sessiz sedasız kaybolmuştur. Yine de Türk-Ellen Dostluk Derneği 1950’lerin ilk yarısındaki Türk-Yunan ilişkilerinin sembollerinden biridir. Bu makalede dernekten geriye kalan tek derli toplu kaynak olan dernek tüzüğü, dernek üyelerinin de çalıştığı dönemin gazeteleri ve devlet arşivleri kullanılarak bu kısa ömürlü dostluk derneği ve faaliyetleri anlatılacaktır.
Design of Post Operation Recovery Room Control System Based on Wireless Sensor Network
Authors: Imanniarti Yuni 
Published: June 2021

The recovery room is a room in hospital, where patients are treated after they have undergone surgical operations and recovered from the effects of anesthesia. In recovery room, patients really need a comfort so that they don't experience physical and psychological stress too much. Comfort for everyone is different, but there are several factors that can make the room more comfortable. Therefore, it will take parameters for this research, namely temperature, humidity and lighting.In this study, we will discuss how to design a wireless sensor network system for controlling the recovery room after cesarean operation and how to test sensors on this system and how to display processing result data to a smartphone.This research will explain about the system description of room temperature and humidity, UV light and room light intensity based on wireless sensor network using 2 types of nodes, namely sink nodes and control sensor nodes and using the HC-12 wireless module as data sender and receiver between nodes. The data taken is related to the measurement result information data that will be accessed and displayed via Android application in realtime.From the system designed, the error value is obtained with an average temperature value on R1 of 1.16%, R2 is 2.64% and R3 is 5.36%, while for the humidity value on R1 is 3.70%, R2 is 9, 32% and R3 10.54%. For testing the communication distance of 10m, the delay value without barrier is 60 seconds, while with barrier, the delay value is 97 seconds.
Penurunan Nyeri Pada Arthritis Gout Melalui Kompres Hangat Air Rebusan Serai
Authors: Oktavianti Dewi Siti , Anzani Siti 
Published: June 2021

Introduction: Gout arthritis is a type of arthritis that caused too much uric acid in the blood and accumulation of uric acid crystals and causing pain. This pain will interfere with activities. The study aims to determine the effect of warm compresses of Boiled lemon Grass reduce the intensity pain of gout. Method: This research used Quasi Experiment design, pre-test and post-test without control. The research samples were 20 respondents who feel pain gout arthritis and have increased levels of uric acid in the blood. The instruments used were the observation sheet and pain intensity scale measurement sheet with Numeric Rating Scale (NRS). The statistical test used the Paired T Test. Results: The results showed that differences in the pain intensity before and after intervention with p value 0.005, meaning there was a significant effect warm compressed of Boiled lemon Grass to reduce pain in Gout arthritis. Conclusion: The warm compresses of Boiled lemon Grass can be used as a non-pharmacological therapy to reduce the pain of gout arthritis.
Pengaruh Terapi Kelompok Terapeutik Terhadap Peningkatan Perkembangan Psikososial Dan Emosi Anak Remaja
Authors: Arifuddin Arifuddin , Pangaribuan Helena 
Published: June 2021

Penelitian ini bertujuan mengidentiifikasi pengaruh terapi kelompok terapeutik terhadap peningkatan perkembangan psikososial dan emosi, hal ini dilakukan dengan melihat perubahan perkembangan psikososial sebelum dan sesudah dilakukan terapi kelompok terapeuti pada kelompok perlakuan serta menganalisis perbedaan perkembangan psikososisal emosi antara kelompok intervensi yang diberikan terapi kelompok terapeutik dan kelompok kontrolTerapi kelompok adalah suatu bentuk terapi dimana sekelompok klien bertemu secara bersama-sama dengan seorang terapis (Nevid, Rathus, & Greene, 2008). Terapi kelompok terapeutik adalah terapi yang fokus utamanya untuk mencegah gangguan dengan cara mengajarkan cara yang efektif untuk mengatasi stres emosional pada satu situasi atau krisis perkembangan, ( Townsend, 2014). Desain yang digunakan dalam penelitian ini adalah Quasi eksperimen dengan pendekatan pre test – pos test control group ( Sudigdo, 1995). Hasil penelitian menunjukkan bahwa terdapat perubahan skor perkembangan psikosiial sebelum dan sesudah diberikan terapi kelompok terapeutik dengan signifikansi dan terdapat perubahan skor perkembangan emosi sebelum dan sesudah diberikan terapi kelompok terapeutik dengan signifikansi lebih kecil dari , Hasil penelitian menunjukkan bahwa tidak terdapat perubahan skor perkembangan psikososial kemampuan sebelum dan sesudah diberikan penyuluhan kesehatan hasil uji T berpasangan (paired –sampel T test ) , bahwa tidak terdapat perubahan skor perkembangan kemampuan emosi sebelum dan sesudah diberikan penyuluhan kesehatan hasil uji T berpasangan ( paired –sampel T test ) , terdapat perbedaan selisih skor pre test dan post test perkembangan psikososial yang bermakna antara kelompok intervensi dan kontrol, Berdasarkan uji t tidak berpasangan (independent-sampel t test) menunjukkan nilai t hitung sebesar 5,793 dan nilai signifikansi 0,000 oleh karena t hitung > t tabel (5,793 > 2,110) dan nilai signifikansi lebih kecil dari 0,05.
The Gut Microbiota of Critically Ill Patients With COVID-19
Authors: Gaibani Paolo , D’Amico Federica , Bartoletti Michele , Lombardo Donatella , Rampelli Simone , Fornaro Giacomo , Coladonato Simona , Siniscalchi Antonio , Re Maria Carla , Viale Pierluigi , Brigidi Patrizia , Turroni Silvia , Giannella Maddalena 
Published: June 2021

The SARS-CoV-2-associated COVID-19 pandemic has shaken the global healthcare system. Although the best-known symptoms are dry cough and pneumonia, viral RNA has been detected in the stool and about half of COVID-19 patients exhibit gastrointestinal upset. In this scenario, special attention is being paid to the possible role of the gut microbiota (GM). Fecal samples from 69 COVID-19 patients from three different hospitals of Bologna (Italy) were analyzed by 16S rRNA gene-based sequencing. The GM profile was compared with the publicly available one of healthy age- and gender-matched Italians, as well as with that of other critically ill non-COVID-19 patients. The GM of COVID-19 patients appeared severely dysbiotic, with reduced diversity, loss of health-associated microorganisms and enrichment of potential pathogens, particularly Enterococcus. This genus was far overrepresented in patients developing bloodstream infections (BSI) and admitted to the intensive care unit, while almost absent in other critically ill non-COVID-19 patients. Interestingly, the percentage of patients with BSI due to Enterococcus spp. was significantly higher during the COVID-19 pandemic than in the previous 3 years. Monitoring the GM of critically ill COVID-19 patients could help clinical management, by predicting the onset of medical complications such as difficult-to-treat secondary infections.
The Role of the IL-23/IL-17 Axis in Disease Initiation in Spondyloarthritis: Lessons Learned From Animal Models
Authors: Mandour Mohamed , Chen Sijia , van de Sande Marleen G. H. 
Published: June 2021

Spondyloarthritis (SpA) is a spectrum of chronic inflammatory joint diseases that frequently presents with inflammation of the axial skeleton, peripheral joints, entheses, skin, and gut. Understanding SpA pathogenesis has been proven challenging due to the limited availability of human target tissues. In recent years, the interleukin (IL)-23/IL-17 pathway has been implicated in the pathogenesis of SpA, in addition to the Tumor Necrosis Factor Alpha (TNF-α) cytokine. The underlying molecular mechanisms by which the IL-23/IL-17 pathway triggers disease initiation, both in the joints as well as at extra-musculoskeletal sites, are not precisely known. Animal models that resemble pathological features of human SpA have provided possibilities for in-depth molecular analyses of target tissues during various phases of the disease, including the pre-clinical initiation phase of the disease before arthritis and spondylitis are clinically present. Herein, we summarize recent insights gained in SpA animal models on the role of the IL-23/IL-17 pathway in immune activation across affected sites in SpA, which include the joint, entheses, gut and skin. We discuss how local activation of the IL-23/IL-17 axis may contribute to the development of tissue inflammation and the onset of clinically manifest SpA. The overall aim is to provide the reader with an overview of how the IL-23/IL-17 axis could contribute to the onset of SpA pathogenesis. We discuss how insights from animal studies into the initiation phase of disease could instruct validation studies in at-risk individuals and thereby provide a perspective for potential future preventive treatment.
EVA1C Is a Potential Prognostic Biomarker and Correlated With Immune Infiltration Levels in WHO Grade II/III Glioma
Authors: Hu Zhicheng , Qu Shanqiang 
Published: June 2021

BackgroundImmunotherapy is an effective therapeutic approach for multiple human cancer types. However, the correlations between EVA1C and patients’ prognosis as well as immune infiltration remain obscure. Herein, we employed transcriptomic and clinical data extracted from two independent databases to systematically investigate the role of EVA1C in the oncological context.MethodsThe differential expression of EVA1C was analyzed via TCGA and Oncomine databases. We evaluated the influence of EVA1C on clinical prognosis using Kaplan-Meier plotter. We then used the expression profiler to calculate stromal score, immune score, and ESTIMATE score based on the ESTIMATE algorithm. The abundance of infiltrating immune cells was calculated via TIMER. The correlations between EVA1C expression and immune infiltration levels were analyzed in two independent cohorts.ResultsIn patients with World Health Organization (WHO) grade II/III glioma, high EVA1C expression was associated with malignant clinicopathological features and poor overall survival in both cohorts. EVA1C expression was positively associated with immune infiltration levels of B cell, CD4+ T cell, neutrophil, macrophage, and dendritic cells (DCs). Besides, EVA1C expression strongly correlated with diverse immune marker sets. And the predictive power of EVA1C was better than that of other indicators in predicting high immune infiltration levels in glioma.ConclusionsFor the first time, we identified the overexpression of EVA1C in glioma, which was tightly correlated with the high infiltration levels of multiple immune cells as well as poor prognosis. Meanwhile, EVA1C might be a potential biomarker for predicting high immune infiltration in WHO grade II/III gliomas.
Limitations of a Commercial Assay as Diagnostic Test of Autoimmune Encephalitis
Authors: Ruiz-García Raquel , Muñoz-Sánchez Guillermo , Naranjo Laura , Guasp Mar , Sabater Lidia , Saiz Albert , Dalmau Josep , Graus Francesc , Martinez-Hernandez Eugenia 
Published: June 2021

Detection of neuronal surface antibodies (NSAb) is important for the diagnosis of autoimmune encephalitis (AE). Although most clinical laboratories use a commercial diagnostic kit (Euroimmun, Lübeck, Germany) based on indirect immunofluorescence on transfected cells (IIFA), clinical experience suggests diagnostic limitations. Here, we assessed the performance of the commercial IIFA in serum and CSF samples of patients with suspected AE previously examined by rat brain immunohistochemistry (Cohort A). Of 6213 samples, 404 (6.5%) showed brain immunostaining suggestive of NSAb: 163 (40%) were positive by commercial IIFA and 241 (60%) were negative. When these 241 samples were re-assessed with in-house IIFA, 42 (18%) were positive: 21 (9%) had NSAb against antigens not included in the commercial IIFA and the other 21 (9%) had NSAb against antigens included in the commercial kit (false negative results). False negative results occurred more frequently with CSF (29% vs 10% in serum) and predominantly affected GABABR (39%), LGI1 (17%) and AMPAR (11%) antibodies. Results were reproduced in a separate cohort (B) of 54 AE patients with LGI1, GABABR or AMPAR antibodies in CSF which were missed in 30% by commercial IIFA. Patients with discordant GABABR antibody results (positive in-house but negative commercial IIFA) were less likely to develop full-blown clinical syndrome; no significant clinical differences were noted for the other antibodies. Overall, NSAb testing by commercial IIFA led to false negative results in a substantial number of patients, mainly those affected by anti-LG1, GABABR or AMPAR encephalitis. If these disorders are suspected and commercial IIFA is negative, more comprehensive antibody studies are recommended.
Young Domestic Pigs (Sus scrofa) Can Perform Pavlovian Eyeblink Conditioning
Authors: Boele Henk-Jan , Joung Sangyun , Fil Joanne E. , Mudd Austin T. , Fleming Stephen A. , Koekkoek Sebastiaan K. E. , Dilger Ryan N. 
Published: June 2021

Introduction: Pigs have been an increasingly popular preclinical model in nutritional neuroscience, as their anatomy, physiology, and nutrition requirements are highly comparable to those of humans. Eyeblink conditioning is one of the most well-validated behavioral paradigms in neuroscience to study underlying mechanisms of learning and memory formation in the cerebellum. Eyeblink conditioning has been performed in many species but has never been done on young pigs. Therefore, our aim here was to develop and validate an eyeblink conditioning paradigm in young pigs.Method: Eighteen intact male pigs were artificially reared from postnatal day 2–30. The eyeblink conditioning setup consisted of a sound-damping box with a hammock that pigs were placed in, which allowed the pig to remain comfortable yet maintain a typical range of head motion. In a delay conditioning paradigm, the conditional stimulus (CS) was a 550 ms blue light-emitting diode (LED), the unconditional stimulus (US) was a 50 ms eye air-puff, the CS-US interval was 500 ms. Starting at postnatal day 14, pigs were habituated for 5 days to the eyeblink conditioning setup, followed by 5 daily sessions of acquisition training (40 paired CS-US trials each day).Results: The group-averaged amplitude of conditioned eyelid responses gradually increased over the course of the 5 days of training, indicating that pigs learned to make the association between the LED light CS and the air-puff US. A similar increase was found for the conditioned response (CR) probability: the group-averaged CR probability on session 1 was about 12% and reached a CR probability of 55% on day 5. The latency to CR peak time lacked a temporal preference in the first session but clearly showed preference from the moment that animals started to show more CRs in session 2 and onwards whereby the eyelid was maximally closed exactly at the moment that the US would be delivered.Conclusion: We concluded that 3-week-old pigs have the capability of performing in a cerebellar classical conditioning task, demonstrating for the first time that eyeblink conditioning in young pigs has the potential to be a valuable behavioral tool to measure neurodevelopment.
Effectiveness of Nutritional Advice for Community-Dwelling Obese Older Adults With Frailty: A Systematic Review and Meta-Analysis
Authors: Yin Yue-Heng , Liu Justina Yat Wa , Fan Tsz Man , Leung Kit Man , Ng Man Wai , Tsang Tsun Yee , Wong Ka Po , Välimäki Maritta 
Published: June 2021

Objectives: This systematic review was aimed to examine the effectiveness of nutritional advise interventions compared with usual care, or exercise, or exercise combined with nutritional advice as a means of improving the body weight, body composition, physical function, and psychosocial well-being of frail, obese older adults.Methods: CINAHL, Cochrane Library, Embase, MEDLINE, PsycINFO, and Scopus databases were searched to identify relevant studies. The quality of the included studies was assessed using Cochrane's risk of bias tool 2. Meta-analysis was performed with respect to body weight and fat mass. Other outcomes were synthesized narratively.Results: Eight articles (from two studies) with a total of 137 participants were included in the review. The results revealed that nutritional advice was more effective than exercise in reducing body weight and fat mass. The nutritional advice was also beneficial in enhancing physical function and psychosocial well-being. However, it was less effective than exercise or combined interventions in increasing muscle strength and preventing lean mass loss.Conclusions: Nutritional advice is an essential intervention for reducing body weight and fat mass, for enhancing physical function, and for improving the psychosocial well-being of obese older adults experiencing frailty. The limited number of studies included in this review suggests that there is a need for more well-designed interventional studies in order to confirm these findings.
Establishment of an Ultrasound Malignancy Risk Stratification Model for Thyroid Nodules Larger Than 4 cm
Authors: Xi Xuehua , Wang Ying , Gao Luying , Jiang Yuxin , Liang Zhiyong , Ren Xinyu , Gao Qing , Lai Xingjian , Yang Xiao , Zhu Shenling , Zhao Ruina , Zhang Xiaoyan , Zhang Bo 
Published: June 2021

BackgroundThe incidence and mortality of thyroid cancer, including thyroid nodules &gt; 4 cm, have been increasing in recent years. The current evaluation methods are based mostly on studies of patients with thyroid nodules &lt; 4 cm. The aim of the current study was to establish a risk stratification model to predict risk of malignancy in thyroid nodules &gt; 4 cm.MethodsA total of 279 thyroid nodules &gt; 4 cm in 267 patients were retrospectively analyzed. Nodules were randomly assigned to a training dataset (n = 140) and a validation dataset (n = 139). Multivariable logistic regression analysis was applied to establish a nomogram. The risk stratification of thyroid nodules &gt; 4 cm was established according to the nomogram. The diagnostic performance of the model was evaluated and compared with the American College Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS), Kwak TI-RADS and 2015 ATA guidelines using the area under the receiver operating characteristic curve (AUC).ResultsThe analysis included 279 nodules (267 patients, 50.6 ± 13.2 years): 229 were benign and 50 were malignant. Multivariate regression revealed microcalcification, solid mass, ill-defined border and hypoechogenicity as independent risk factors. Based on the four factors, a risk stratified clinical model was developed for evaluating nodules &gt; 4 cm, which includes three categories: high risk (risk value = 0.8-0.9, with more than 3 factors), intermediate risk (risk value = 0.3-0.7, with 2 factors or microcalcification) and low risk (risk value = 0.1-0.2, with 1 factor except microcalcification). In the validation dataset, the malignancy rate of thyroid nodules &gt; 4 cm that were classified as high risk was 88.9%; as intermediate risk, 35.7%; and as low risk, 6.9%. The new model showed greater AUC than ACR TI-RADS (0.897 vs. 0.855, p = 0.040), but similar sensitivity (61.9% vs. 57.1%, p = 0.480) and specificity (91.5% vs. 93.2%, p = 0.680).ConclusionMicrocalcification, solid mass, ill-defined border and hypoechogenicity on ultrasound may be signs of malignancy in thyroid nodules &gt; 4 cm. A risk stratification model for nodules &gt; 4 cm may show better diagnostic performance than ACR TI-RADS, which may lead to better preoperative decision-making.
Sleep-Related Breathing Problem Trajectories Across Early Childhood and Academic Achievement-Related Performance at Age Eight
Authors: Harding Rebecca , Schaughency Elizabeth , Haszard Jillian J. , Gill Amelia I. , Luo Rebekah , Lobb Carmen , Dawes Patrick , Galland Barbara 
Published: June 2021

Background:Childhood sleep disordered breathing (SDB) has been linked to poorer academic performance; however, research has not investigated the extent improvement in SDB may alter outcomes across key academic skills. This study aimed to investigate if children's early SDB status could predict later academic outcomes, and if an improvement in SDB status across the early childhood years would coincide with better, later performance in key academic skills related to reading, numeracy, and listening comprehension.Methods:Eighty five case children with an SDB symptom score &gt;25 (maximum 77) were matched to 85 control children (score &lt;12) at recruitment (age 3). SDB severity (symptom history and clinical assessment) was evaluated at ages 3, 4, 6, and 8 years and performance on individually-administered academic skills assessed at age 8 (91% retention from age 3). Case children were categorized into “improved” or “not-improved” groups based on SDB trajectories over the 5 years. Contributions of SDB status and trajectory group to academic performance were determined using regression analysis adjusted for demographic variables.Results:History of SDB from age 3 predicted significantly poorer performance on some key academic skills (oral reading and listening skills) at age 8. Children whose SDB improved (45%) performed better in oral reading fluency than those whose SDB did not improve, but difficulties with specific tasks involving oral language (listening retell) remained when compared to controls.Conclusion:Findings support links between early SDB and worse academic outcomes and suggest key academic areas of concern around oral language. Findings highlight the need for child mental health professionals to be aware of children's sleep problems, particularly SDB (past and present), when assessing potential barriers to children's achievement, to assist with appropriate and timely referrals for evaluation of children's sleep difficulties and collaborative evaluation of response to intervention for sleep difficulties.