bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Dose-Androgen-Induced Autophagic Cell Death to Suppress the Enzalutamide-Resistant Prostate Cancer Growth Via Altering the circRNA-BCL2/miRNA-198/AMBRA1 Signaling
Authors: Chen Lei , Sun Yin , Tang Min , Wu Denglong , Huang Chi-Ping , Yu Bosen , Xie Dongdong , Ye Qinglin , Yu Dexin , Chang Chawnshang 
Published: November 2021

Abstract
Background. Androgen deprivation therapy (ADT) is a gold standard treatment for advanced PCa. However, most patients eventually develop the castration-resistant prostate cancer (CRPC) that progresses rapidly despite ongoing systemic androgen deprivation. While early studies indicated that high physiological doses of androgens might suppress rather than promote PCa cell growth in some selective CRPC patients, the exact mechanism of this opposite effect remains unclear. Results. we found that Enzalutamide-resistant (EnzR) CRPC cells can be suppressed by the high-dose-androgen DHT. Mechanism dissection suggested that a high-dose-DHT can suppress the circular RNA-BCL2 (circRNA-BCL2) expression via transcriptional regulation of its host gene BCL2. The suppressed circRNA-BCL2 can then alter the expression of miRNA-198 to modulate the AMBRA1 expression via direct binding to the 3′UTR of AMBRA1 mRNA. The consequences of high-dose-DHT suppressed circRNA-BCL2/miRNA-198/AMBRA1 signaling may then lead to induction of the autophagic cell death to suppress the EnzR CRPC cell growth. Preclinical studies using in vivo mouse models also demonstrated that AMBRA1-shRNA to suppress the autophagic cell death can weaken the effect of high-dose-DHT on EnzR CRPC tumors. Conclusion. Together, these in vitro and in vivo data provide new insights for understanding the mechanisms underlying high-dose-DHT suppression of the EnzR CRPC cell growth, indicating a potential therapy using high-dose-androgens to suppress CRPC progression in the future.
Transcription Factor Control of Dendrite Targeting via Combinatorial Cell-Surface Codes
Authors: Luo Liqun , Xie Qijing , Li Jiefu , Li Hongjie , Udeshi Namrata , Svinkina Tanya , Kohani Sayeh , Guajardo Ricardo , Mani D. R. , Xu Chuanyun , Li Tongchao , Han Shuo , Wei Wei , Shuster S , Luginbuhl David , Ting Alice , Carr Steven 
Published: November 2021

Abstract
Transcription factors are central commanders specifying cell fate, morphology, and physiology while cell-surface proteins execute these commands through interaction with cellular environment. In developing neurons, it is presumed that transcription factors control wiring specificity through regulation of cell-surface protein expression. However, the number and identity of cell-surface protein(s) a transcription factor regulates remain largely unclear1,2. Also unknown is whether a transcription factor regulates the same or different cell-surface proteins in different neuron types to specify their connectivity. Here we use a lineage-defining transcription factor, Acj6 (ref. 3), to investigate how it controls precise dendrite targeting of Drosophila olfactory projection neurons (PNs). Quantitative cell-surface proteomic profiling of wild-type and acj6 mutant PNs in intact developing brains and a proteome-informed genetic screen identified PN surface proteins that execute Acj6-regulated wiring decisions. These include canonical cell adhesion proteins and proteins previously not associated with wiring, such as the mechanosensitive ion channel Piezo—whose channel activity is dispensable for its wiring function. Comprehensive genetic analyses revealed that Acj6 employs unique sets of cell-surface proteins in different PN types for dendrite targeting. Combinatorial expression of Acj6 wiring executors rescued acj6 mutant phenotypes with higher efficacy and breadth than expression of individual executors. Thus, a key transcription factor controls wiring specificity of different neuron types by specifying distinct combinatorial expression of cell-surface executors.
Enhanced Removal of Pb from Electrolytic Manganese Anode Slime by Vacuum Carbothermal Reduction
Authors: Yang Yong , Shu Jiancheng , Su Pengxin , Wu Haiping , Zhang Lei , Liu Renlong , Liu Zuohua , Chen Mengjun 
Published: November 2021

Abstract
Electrolytic manganese anode slime (EMAS) is produced during the production of electrolytic manganese metal. In this study, a method based on vacuum carbothermal reduction was used for Pb removal in EMAS. A Pb-removal efficiency of 99.85% and MnO purity in EMAS of 97.34 wt.% was obtained for a reduction temperature of 950°C and a carbon mass ratio of 10% for a holding time of 100 min. The dense structure of the EMAS was destroyed, a large number of multidimensional pores and cracks were formed, and the Pd-containing compound was reduced to elemental Pb by the vacuum carbothermal reduction. A recovery efficiency for chemical MnO2 of 36.6% was obtained via preparation from Pd-removed EMAS through the “roasting-pickling disproportionation” process, with an acid washing time of 100 min, acid washing temperature of 70°C, H2SO4 concentration of 0.8 mol/L, liquid-solid mass ratio of 7 mL/g, calcination temperature of 60°C and calcination time of 2.5 h. Moreover, the crystal form of the prepared chemical MnO2 was found to be basically the same as that of electrolytic MnO2, and its specific surface area, micropore volume and discharge capacity were all higher than that of electrolytic MnO2. This study provides a new method for Pd removal and recycling for EMAS.
Urodynamic Findings in Pediatric Spastic Cerebral Palsy: Retrospective Study From a Single Center
Authors: Jiang Wenbin , Sun Huizhen , Gu Baojun , Zhan Qijia , Wei Min , Li Sen , Chen Fang , Xiao Bo 
Published: November 2021

Abstract
Objective To investigate the urodynamic study (UDS) result in pediatric patients with spastic cerebral palsy (CP). Material and methods Medical records of CP with pre-operative UDS results underwent selective dorsal rhizotomy (SDR) from Jan. 2020 to May. 2021 were retrospectively reviewed. Results Fifty-seven cases with spastic CP were included in the study. Among these cases, 46 were ambulatory and 11 were non-ambulatory. Average gross motor function measure - 66 (GMFM - 66) score was 62.16 ± 11.39. Reduced bladder capacity was seen in 49.12% of these cases and cases with lower GMFM - 66 score had a higher incidence rate of having low bladder capacity (p < 0.01). Detrusor overactivity (DO) was shown in 33.33% of patients. Cases with younger age had higher prevalence of DO (p < 0.05). Meanwhile, more non-ambulant patients had DO (p < 0.05). Increased post-voiding residual (PVR) was seen in 21.05% of cases. Those with higher average threshold in sphincter-associated input spinal nerve roots (rootlets) had higher rate of having abnormal PVR (p < 0.05). Conclusion Abnormal UDS results were prevalent in pediatric spastic CP. Motor function, age and threshold of their sphincter-associated spinal nerve rootlets were related to the abnormal UDS results.
An Archimedes' Screw for Light
Authors: Galiffi Emanuele , Huidobro Paloma , Pendry John 
Published: November 2021

Abstract
An Archimedes' Screw captures water, feeding energy into it by lifting it to a higher level. We introduce the first instance of an optical Archimedes' Screw, and demonstrate how this system is capable of capturing light, dragging it and amplifying it. We unveil new exact analytic solutions to Maxwell's Equations for a wide family of chiral space-time media, and show their potential to achieve chirally selective amplification within widely tunable parity-time-broken phases. Our work, which may be readily implemented via pump-probe experiments with circularly polarized beams, opens a new direction in the physics of time-varying media by merging the rising field of space-time metamaterials and that of chiral systems, and offers a new playground for topological and non-Hermitian photonics, with potential applications to chiral spectroscopy and sensing.
A Nationwide Evaluation of the Prevalence of Human Papillomavirus in Brazil (POP-Brazil Study): Protocol for Data Quality Assurance and Control
Authors: Horvath Jaqueline Driemeyer Correia , Bessel Marina , Kops Natália Luiza , Souza Flávia Moreno Alves , Pereira Gerson Mendes , Wendland Eliana Marcia 
Published: November 2021

Background
The credibility of a study and its internal and external validity depend crucially on the quality of the data produced. An in-depth knowledge of quality control processes is essential as large and integrative epidemiological studies are increasingly prioritized.

Objective
This study aimed to describe the stages of quality control in the POP-Brazil study and to present an analysis of the quality indicators.

Methods
Quality assurance and control were initiated with the planning of this nationwide, multicentric study and continued through the development of the project. All quality control protocol strategies, such as training, protocol implementation, audits, and inspection, were discussed one by one. We highlight the importance of conducting a pilot study that provides the researcher the opportunity to refine or modify the research methodology and validating the results through double data entry, test-retest, and analysis of nonresponse rates.

Results
This cross-sectional, nationwide, multicentric study recruited 8628 sexually active young adults (16-25 years old) in 119 public health units between September 2016 and November 2017. The Human Research Ethics Committee of the Moinhos de Vento Hospital approved this project.

Conclusions
Quality control processes are a continuum, not restricted to a single event, and are fundamental to the success of data integrity and the minimization of bias in epidemiological studies. The quality control steps described can be used as a guide to implement evidence-based, valid, reliable, and useful procedures in most observational studies to ensure data integrity.

International Registered Report Identifier (IRRID)
RR1-10.2196/31365
Predicting New Daily COVID-19 Cases and Deaths Using Search Engine Query Data in South Korea From 2020 to 2021: Infodemiology Study
Authors: Husnayain Atina , Shim Eunha , Fuad Anis , Su Emily Chia-Yu 
Published: November 2021

Background
Given the ongoing COVID-19 pandemic situation, accurate predictions could greatly help in the health resource management for future waves. However, as a new entity, COVID-19’s disease dynamics seemed difficult to predict. External factors, such as internet search data, need to be included in the models to increase their accuracy. However, it remains unclear whether incorporating online search volumes into models leads to better predictive performances for long-term prediction.

Objective
The aim of this study was to analyze whether search engine query data are important variables that should be included in the models predicting new daily COVID-19 cases and deaths in short- and long-term periods.

Methods
We used country-level case-related data, NAVER search volumes, and mobility data obtained from Google and Apple for the period of January 20, 2020, to July 31, 2021, in South Korea. Data were aggregated into four subsets: 3, 6, 12, and 18 months after the first case was reported. The first 80% of the data in all subsets were used as the training set, and the remaining data served as the test set. Generalized linear models (GLMs) with normal, Poisson, and negative binomial distribution were developed, along with linear regression (LR) models with lasso, adaptive lasso, and elastic net regularization. Root mean square error values were defined as a loss function and were used to assess the performance of the models. All analyses and visualizations were conducted in SAS Studio, which is part of the SAS OnDemand for Academics.

Results
GLMs with different types of distribution functions may have been beneficial in predicting new daily COVID-19 cases and deaths in the early stages of the outbreak. Over longer periods, as the distribution of cases and deaths became more normally distributed, LR models with regularization may have outperformed the GLMs. This study also found that models performed better when predicting new daily deaths compared to new daily cases. In addition, an evaluation of feature effects in the models showed that NAVER search volumes were useful variables in predicting new daily COVID-19 cases, particularly in the first 6 months of the outbreak. Searches related to logistical needs, particularly for “thermometer” and “mask strap,” showed higher feature effects in that period. For longer prediction periods, NAVER search volumes were still found to constitute an important variable, although with a lower feature effect. This finding suggests that search term use should be considered to maintain the predictive performance of models.

Conclusions
NAVER search volumes were important variables in short- and long-term prediction, with higher feature effects for predicting new daily COVID-19 cases in the first 6 months of the outbreak. Similar results were also found for death predictions.
Reforma a las pensiones por vejez como paliativo a la falta del seguro de desempleo y de dependencia
Authors: Mendizábal Bermúdez Gabriela 
Published: November 2021

<p>Un sistema de seguridad social debidamente estructurado protege a la población de las contingencias y las necesidades derivadas de ellas, a través de diversos seguros. De esta forma se cuenta en México con los seguros de riesgos de trabajo; enfermedades y maternidad; invalidez y vida; cesantía en edad avanzada y vejez; y guarderías y prestaciones sociales. </p><p>Sobre el seguro de vejez, es importante reconocer que no sólo existe el riesgo de envejecer, sino que además a lo largo de la vida existe la posibilidad de quedar desempleado y no poder cotizar las semanas necesarias para obtener una pensión por vejez, y también existe la posibilidad de convertirse en algún momento de la vida en una persona dependiente de otra, ya sea derivado de un accidente, enfermedad o por el simple paso del tiempo. </p><p>En ese sentido, el objetivo del presente capítulo es demostrar que se requiere una reforma a la seguridad social de México que atienda la problemática ocasionada por tres contingencias que inciden directamente en la vida de los adultos mayores: el desempleo a lo largo de la vida laboral, la dependencia y por supuesto las consecuencias de la propia vejez. </p>
Perbandingan Perhitungan BoQ dengan Menggunakan Revit 2019 Terhadap Perhitungan BoQ dengan Menggunakan Metode Konvensional pada Pekerjaan Struktur (Studi Kasus: Gedung G Fakultas Pertanian Universitas Lampung)
Authors: Laily Fasya Noor , Husni Hasti Riakara , Bayzoni Bayzoni 
Published: November 2021

Penelitian ini dilakukan untuk mengeksplorasi potensi BIM dan mengetahui perbandingan perhitungan BoQ menggunakan Revit 2019 dan menggunakan metode konvensional pada pekerjaan struktur yang terdiri dari volume fondasi, lantai, kolom, balok, tangga, ramp, tulangan sekaligus perhitungan baja ringan untuk rangka atap. Hasil dari penelitian ini dapat digunakan sebagai tambahan acuan dan pertimbangan dalam merencanakan suatu pekerjaan konstruksi berbasis BIM. Penelitian ini menggunakan Gedung G Fakultas Pertanian Universitas Lampung sebagai studi kasus penelitian. Berdasarkan penelitian yang dilakukan, didapatkan hasil bahwa persentase rasio perhitungan BoQ menggunakan Revit 2019 dengan perhitungan BoQ menggunakan metode konvensional untuk pekerjaan fondasi adalah 96,5%, lantai 98,17%, kolom 89,37%, balok 88,88%, tangga 90,35%, tulangan 112,18%, baja CNP 82,04%, baja IWF 81,54%, reng baja ringan 100,18%. Dari hasil pemodelan dan perhitungan yang telah dilakukan, dapat disimpulkan bahwa perhitungan BoQ dengan Revit 2019 dapat dilakukan dengan cepat, efektif, dan menghasilkan hasil yang akurat. Hal ini dapat dilihat dari rata-rata rasio perhitungan BoQ dengan menggunakan Revit 2019 terhadap perhitungan BoQ dengan menggunakan metode konvensional yang sebesar 93,25%. Dari hal ini pula dapat dibuktikan bahwa pemodelan dengan Revit 2019 dapat dilakukan secara efektif dan efisien karena Revit 2019 mampu meminimalisasikan kemungkinan terjadinya kesalahan akibat human error pada saat proses mendesain maupun menghitung BoQ.
Porównanie wybranych odmian wiechliny łąkowej (Poa pratensis) użytkowanej w systemie ‘park’
Authors: GRYGIERZEC BEATA , JANUS BARBARA 
Published: November 2021

Badania zrealizowano w latach 2011–2012 w Gnatowicach koło Krakowa. Ich celem była ocena wybranych odmian wiechliny łąkowej użytkowanej w systemie ‘park’. U badanych odmian: ‘Alicja’, ‘Ani’, ‘Bila’, ‘Conni’, ‘Evora’ oraz ‘Limousine’ dokonano oceny: stanu roślin wiosną i jesienią, ogólnego aspektu estetycznego (OA), zadarnienia (Z), intensywności odrastania (IO) oraz występowania chorób. Wiosną najlepszym stanem cechowała się odmiana ‘Limousine’, natomiast najgorszym ‘Evora’. Sposób przezimowania był istotnie zróżnicowany u każdej odmiany. Ogólny aspekt estetyczny i zadarnienie było zależne od odmiany, pory i roku badań. Najbardziej atrakcyjnie rośliny wyglądały latem, natomiast najgorzej jesienią. Na ogół większą intensywnością odrastania cechowały się odmiany w drugim roku badań, wyjątkami pod tym względem były ‘Conni’ i ‘Evora’. Największe nasilenie dwóch chorób – Microdochium nivale i Entyloma dactylidis – zaobserwowano wiosną. Najbardziej porażone przez Puccinia striiformis były rośliny jesienią. Najłagodniejsze objawy Drechslera poae odnotowano latem u wszystkich odmian wiechliny łąkowej.
A Thomistic Defense of “Nature” in Avicenna’s Physics
Authors: Peters Catherine 
Published: November 2021

Abstract
Avicenna offers a novel definition of “nature” as a power in his Physics of the Healing. Some have seen in this redefinition a radical departure from Aristotle. James Weisheipl, for one, rejected Avicenna’s definition as a mistaken interpretation of Aristotle and as a position incompatible with Thomas Aquinas. In Weisheipl’s view, Avicenna reifies form into a kind of motor of the natural being, a conception earlier rejected by Thomas Aquinas in several works. In this study, I offer a Thomistic defense of Avicenna by investigating the definition of nature and its relation to matter and form.
A STUDY OF JARGON USED ON FOOD & BEVERAGE DIVISION AT THE ALIMAR PREMIER HOTEL SURABAYA
Authors: Budianto Suhartawan , Pramesti Mutiara Widya Noor 
Published: November 2021

This research focuses on study of the forms of jargon and functions that used by foodandbeveragedivisionatTheAlimarPremierHotelSurabaya.The study writer uses the theory of sociolinguisticsby Chaer (1994) to answer the language varities in the form of jargon and also the theory of function of jargon by Ives (1999) that used by the employeesin the food and beverage division at The Alimar Premier Hotel Surabaya. This study uses qualitative method to analyze the jargon. The aim ofqualitativemethoditselfistoobtainsystematicallydescriptionandaccuratefacts. It concerns with the collected data that often uses words. To collect the data, the first step that the thesis writer used was recording some conversations between the employees in thesame division. After recording the conversations, the thesis writer transcribes the data into a table and classifies what are the inventions of the language varities in the form of jargon shich is found inthe conversation. After analyzing the data, the jargon that usually spoken by the employees in the food and beverage division are in the form words and phrases. By using jargon to explain somethingtothesamedivision,theyareabletospeakusingmorelanguagevarieties
COMPARATIVE LITERATURE IN FAULKNER’S A ROSE FOR EMILY AND PRAMOEDYA’S PANGGIL SAJA AKU KARTINI
Authors: Masofa Ima 
Published: November 2021

Abstract: This article analyzes comparative literature in Faulkner’s A Rose For Emily and Pramoedya’s Panggil Aku Kartini Saja.The researcher analyzes comparative literature that uses American School to compare how the society’s role effects to the main characters in Faulkner’s A Rose For Emily and Pramoedya’s Panggil Aku Kartini Saja.. Faulkner’s A Rose for Emily and Pramoedya’s Panggil Aku Kartini Saja have same backgrounds of women’s life. Kartini in Pramoedya’s Panggil Aku Kartini Saja and Emily in Faulkner’s A Rose for Emily are from noble that rule Kartini and Emily. This article attempts to find similarities and dissimilarities of the woman in Faulkner’s A Rose For Emily and Pramoedya’s Panggil Aku Kartini Saja.The results of this research can be formulated as follows: 1)Similarities are that both Emily and Kartini are from noble family. 2) Differences are that Kartini can influence women at the time to get their right,but Emily lives in fear because of her society rule.Keywords: Comparative Literature,American School,
Morphological Diversities revealed in Rahimi’s Novel The Patience Stone
Authors: Ariwibowo Syamsuri 
Published: November 2021

This study aims to find out the diversity of morphemes appearing in every word in the novel. The problems being solved are the derivational morphemes expressed in the novel and the frequency of derivational morphemes that appear in The Patience Stone by Atiq Rahimi. Hopefully, it could be helpful and useful for application of derivational morpheme correctly. It can also be the reference for learning the word formation. The research method used to analyze the data is descriptive design. Data are taken from the novel of The Patience Stone about any words containing derivational morpheme and the technique of data analysis used is classification of every word and tabels of the frequency of derivational morpheme. The finding indicates that derivational suffix -ly is the most frequent morpheme that appears in the novel. The derivational suffix -hood and -ship are the least frequency of derivational morpheme. Key Words : Word-formation, Morpheme, Affixes
THE ILLUSION OF WILLY LOMAN’S IN ARTHUR MILLER’S DEATH OF A SALESMAN
Authors: Sumarsono Irwan 
Published: November 2021

This study discusses the illusion and explains the conditions that lead the main character, Willy Loman to be in illusion. The analysis will be focused on the characterization of Willy Loman, his marriage with Linda Loman, his relationship with his sons, Biff and Happy. The analysis also focuses on the illusion of Willy Loman by discovering why he cannot face the reality and what the effects to his life. To analyze these problems, the writer uses the psychological approach since psychology and literary works cannot be separated.
Comparative Studies in Aesop’s The Lion and The Mouse and The Fox and The Cat
Authors: Masofa Ima 
Published: November 2021

This article attempts to analyze Comparative Studies in Aesop’s The Lion and The Mouse and The Fox and The Cat that uses comparative studies to find differences and similarities of resolution in Aesop’s The Lion and The Mouse and The Fox and The Cat.This article uses resolution concepts that two stories have collective unconsciousness that little friends may prove great friends. This article uses comparative studies to find resolution in Aesop’s The Lion and The Mouse and The Fox and The Cat.The study aims at comparing two different literary works that describe how the two main characters from the two stories face complication and achieve resolution.The results of this article can be formulated as follows: 1) Resolution concepts can be seen in Aesop’s The Lion and The Mouse and The Fox and The Cat because they can solve their complications. The two main characters of two stories face complication when they meet a hunter, their friends come to solve complication.2) Aesop’s The Lion and The Mouse and The Fox and The Cat have similarities and differences. The similarities of the two stories are the two main characters faces complication because of hunter, themes of the two stories are friendship. Aesop’s The Lion and The Mouse and The Fox and The Cat achieve resolution by attendance of their friends. The differences of two stories are the way of the two main characters to meet a hunter. In Aesop’s The Lion and The Mouse, The lion can escape from hunter because of the mouse’s help as his friend.In Aesop’s The Fox and The Cat, a cat can escape from hunter because the cat does not follow a fox’s suggestion because his the fox has a hundred safe way from hunter but he cannot save his life from huntsmen.