bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forecasting the effectiveness of the DeWorm3 trial in interrupting the transmission of soil-transmitted helminths in three study sites in Benin, India and Malawi
Authors: Truscott James , Hardwick Robert J , Werkman Marleen , Saravanakumar Puthupalayam Kaliappan , Manuel Malathi , ajjampur Sitara S R , Asbjornsdottir Kristjana H , Khumbo Kalua , Witek-McManus Stefan , Simwanza James , Cottrell Gilles , Houngbégnon Parfait , Ibikounlé Moudachirou , Walson Judd L , Anderson Roy M 
Published: January 2021

Abstract
Background The DeWorm3 project is an ongoing cluster-randomised trial assessing the feasibility of interrupting the transmission of soil-transmitted helminths (STH) through mass drug administration (MDA) using study sites in India, Malawi and Benin. In this paper, we describe an approach which uses a combination of statistical and mathematical methods to forecast the outcome of the trial with respect to its stated goal of reducing the prevalence of infection to below 2%. Methods Our approach is firstly to define the local patterns of transmission within each study site, which is achieved by statistical inference of key epidemiological parameters using the baseline epidemiological measures of age-related prevalence and intensity of STH infection which have been collected by the DeWorm3 trials team. We use these inferred parameters to calibrate an individual-based stochastic simulation of the trial at the cluster and study site level which is subsequently run to forecast the future prevalence of STH infections. The simulator takes into account both the uncertainties in parameter estimation and the variability inherent in epidemiological and demographic processes in the simulator. We interpret the forecast results from our simulation with reference to the stated goal of the DeWorm3 trial, to achieve a target of ≤ 2% prevalence at a point 24 months post-cessation of MDA. Results Simulated output predicts that the two arms will be distinguishable from each other in all three country sites at the study endpoint. In India and Malawi, measured prevalence in the intervention arm is below the threshold with a high probability (90% and 95%, respectively), but that in Benin the heterogeneity between clusters prevents the arm prevalence being reduced below the threshold value. At the level of individual study arms within each site, heterogeneity among clusters leads to a very low probability of achieving complete elimination in an intervention arm, yielding a post-study scenario with widespread elimination but a few `hot spot' areas of persisting STH transmission.Conclusions Our results suggest that geographical heterogeneities in transmission intensity and worm aggregation have a large impact on the effect of MDA. It is important to accurately assessing cluster-level, or even smaller scale, heterogeneities in factors which influence transmission and aggregation for a clearer perspective on projecting the outcomes of MDA control of STH and other neglected tropical diseases.
Association between renal function and platelet reactivity during aspirin therapy in elderly patients with atherosclerotic cardiovascular disease
Authors: Liang Wenyi , Zhang Peng , Liu Meilin 
Published: January 2021

Abstract
Background: Aspirin is the key treatment in the secondary prevention of atherosclerotic cardiovascular disease. High on-treatment platelet reactivity (HTPR) to aspirin has been reported to partially account for the enhanced risk of thrombotic events. In particular, HTPR has been described more frequently among elderly patients. The aim of this study was to identify the clinical and biological factors associated with HTPR in a real-life elderly population.Methods: In this retrospective study, elderly patients with atherosclerotic cardiovascular disease on regular aspirin treatment were enrolled. Cardiovascular risk factors, routine biological parameters, comorbidities, and concomitant medications were recorded. The upper quartile of the platelet aggregation rate, determined by light transmission aggregometry with arachidonic acid, was defined as the HTPR group.Results: A total of 304 patients were included (mean age 77 ± 8 years, 76% men). Patients in the HTPR group were older than the patients in the non-HTPR group (mean age: 79 ± 7 vs. 76 ± 8 years, p = 0.008). Patients with moderately decreased estimated glomerular filtration rate (eGFR) had a higher frequency of HTPR than patients with slightly decreased eGFR or normal eGFR (35.8%, 22.5%, 12.2%, respectively, p < 0.05). In multivariate analysis, an independent risk factor for HTPR was the eGFR (OR: 0.984, 95% CI: 0.980-0.988, p < 0.001).Conclusions: Advanced age and decreased eGFR are correlated with poor pharmacodynamic response to aspirin.
Steganography algorithm based on modified EMD coded PU partition modes for HEVC videos
Authors: Zhang Zhenzhen , Li Zhaohong , Liu Jindou , Yan Huanma , Yu Lifang 
Published: January 2021

Abstract
As High Efficiency Video Coding (HEVC) is a worldwide popular video coding standard, the steganography of HEVC videos has gained more and more attention. Prediction Unit (PU) is one of the most important innovative modules of HEVC, thus PU partition mode based steganography is becoming a novel branch of HEVC steganography. However, the embedding capacity of this kind of steganography is limited by the types of PU partition modes. To solve the problem, modified Exploiting Modification Direction (EMD) coded PU partition modes based steganography is proposed in this paper, which can hide a secret digit in a ( [[EQUATION]] )-ary notational system in a pair of PU partition modes and thus enlarging the capacity. Furthermore, two mapping patterns for PU partition modes are analyzed and the one that performs the better is selected as the final mapping pattern. Firstly, 8×8 and 16×16 sized PU partition modes are recorded according to the optimal mapping pattern in the video encoding process. Then PU partition modes are modified by using the proposed method to satisfy the requirement of secret information. Finally, the stego video can be obtained by re-encoding the video with the modified PU partition modes. Experimental results show that the embedding capacity can be significantly enlarged, and compared with the state-of-the-art work, the proposed method has much larger capacity while keeping high visual quality.
Determination of the role of polymorphic variants of the interferon-gamma gene (<i>IFNG</i>) in the development of tuberculosis in the Yakut population
Authors: Mordovskaya L. I. , Egorova M. V. , Klimova T. M. , Аlekseeva S. D. 
Published: January 2021

The objective of the study: to determine the role of polymorphic variants T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the development of tuberculosis in the population of Yakut nationality.Subjects and methods. The case-control study was conducted. The subject for the study was DNA samples from 172 tuberculosis patients (the case group) and 367 people with an excluded diagnosis of tuberculosis (the control group). All participants of the study belonged to Yakut nationality. For genotyping, DNA was isolated from venous blood. The genotyping was performed by real-time polymerase chain reaction. For statistical processing, Pearson's χ2 test and odds ratio with 95% confidence intervals were used.The results of the study showed that the distribution of genotypes of polymorphisms T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the case and control groups corresponded to the Hardy – Weinberg equilibrium. There was no statistically significant difference in frequencies of alleles and genotypes of polymorphisms T6000A (rs2430561), T8360C (rs2069718) of the IFNG gene in the patients from the case and control groups.Conclusions. The results of the study did not reveal the association of alleles and genotypes of the rs2430561 and rs2069718 polymorphic variants of the IFNG gene with the risk of developing tuberculosis for people of Yakut nationality.
ACREDITAÇÃO HOSPITALAR COMO FERRAMENTA PARA A GESTÃO DA QUALIDADE NO BRASIL: CARACTERÍSTICAS, AVANÇOS E DESAFIOS
Authors: MATIAS DO NASCIMENTO JULIO CESAR 
Published: January 2021

Resumo: A acreditação é um metodo para a excelência em gestão e assistência em saúde. Objetivou-se, por meio de uma revisão integrativa da literatura, identificar características e avanços da acreditação nos hospitais brasileiros e as dificuldades do serviço de gestão da qualidade. Foram rastreados 702 estudos nas bases de dados eletrônicas, que após elegibilidade considerou-se 08 artigos para esta revisão, publicados entre 2011-2018. A rede privada representou 65% dos locais de estudo e a Organização Nacional de Acreditação foi a principal certificadora (75%). Os enfermeiros realizaram 75% dos estudos, sendo relevantes na gestão da qualidade. Os hospitais buscam na acreditação aprimorar a gestão e a segurança do paciente, aumentar a produção e a competição no mercado. É primordial sensibilizar colaboradores, manter comunicação eficiente e valorizar o profissional. Há dificuldades com a mudança da cultura organizacional e a rotatividade de funcionários. A acreditação promoveu a satisfação e o reconhecimento profissional, a padronização de processos, a consolidação de programas de educação, a segurança do paciente e a avaliação contínua dos serviços e desempenho profissional.

Palavras-chave: Acreditação hospitalar; Gestão da qualidade; Gestão em saúde.
The relationship of risk factors and heart remodeling in patients with metabolic syndrome and arterial hypertension
Authors: Polozova E. L. , Puzanova E. V. , Seskina A. A. , Nefedov N. S. 
Published: January 2021

Introduction. Arterial hypertension (AH) is a widespread disease in the population of the world. It also acts as one of the constituent components of metabolic syndrome (MS), which is a global “epidemic” of our time. Target organs in such patients are affected much earlier and their changes are more pronounced than in hypertensive patients without metabolic disorders. It is important to study the contribution of risk factors to the progression of cardiac dysfunction in this category of patients.Purpose of the study. To study the influence of risk factors on heart remodeling in patients with hypertension, burdened and not burdened by metabolic disorders, selected for clinical analysis from the cardiology department of the Republican Clinical Hospital № 4, Saransk in 2016-2019.Materials and methods. For clinical analysis, 139 patients were selected from the cardiology department of the Republican Clinical Hospital No. 4, Saransk. Depending on the presence of metabolic disorders, the following groups were identified: Group I (n = 72) – patients with MS and AH; Group II (n = 67) – AH patients without metabolic disorders. The study evaluated the morphological and functional state of the myocardium and risk factors in the analyzed groups.Results. In the group of patients with hypertension, aggravated by metabolic disorders, more pronounced processes of cardiac remodeling were revealed. It has been shown that patients with MS develop both eccentric and concentric models of left ventricular hypertrophy. The influence of the level of blood pressure and body mass index is differently reflected on the type of restructuring of the geometry of the myocardium. Patients with hypertension combined with metabolic disorders have a wider prevalence of risk factors. The burden of risk factors is higher in patients with concentric left ventricular hypertrophy and MS.Conclusions. The role of metabolic disorders in the mechanism of cardiac remodeling development in patients with hypertension in combination with MS was determined.
Highlighting Aglycone-dependent Glycosylation Aspects in Caryophyllaceae Saponins by a Simplex Simulation Approach
Authors: Hammami Asma , Farman Muhammad , Semmar Nabil 
Published: January 2021

Background:
Saponin metabolism shows high structural variability due to the diversity
of aglycones and glycosylations (Gly). Although they represent a potential source of drug design,
their metabolism remains misunderstood yet due to insufficient investments in analytical methods.

Aims:
Bibliographic structural data offer a wide field for extensive statistical analysis, highlighting
mechanistic orders governing metabolic diversity. This work presents an original simulation
method based on simplex rule for highlighting regulatory mechanisms of metabolism from categorical
structural data.

Methods:
Simulation was applied on a set of 231 saponins of the Caryophyllaceae plant family initially
affiliated to four aglycone types: gypsogenin (Gyp), quillaic acid (QA), gypsogenic acid
(GA), and 16-OH-gypsogenic acid (16-OH-GA). Molecules were initially characterized by relative
glycosylation levels of different carbons. Simplex approach was applied by combining saponins of
the four aglycone groups using a complete set of N gradual weightings between structural groups.
In silico combinations were applied by randomly sampling representative saponins from the four
groups conforming to their weights given by mixture design. Gly profiles of sampled saponins
were averaged to calculate a barycentric molecular profile for each mixture. With N mixtures, N
barycentric molecules were iteratively calculated by bootstrap, leading to smoothed data from
which Gly trends between carbons were highlighted.

Results:
Sequential, competing and cooperative Gly trends were highlighted according to the types
of aglycones, attached saccharides and positions of substituted carbons. Such various conditional
Gly trends seemed to be linked to multiple factors, including steric effects, regio-selectivity, enzymatic
specificity and enzymatic promiscuity. These simulated results could be helpfully useful in
chemical synthesis and drug design.

Conclusion:
These simulated results could usefully help for chemical syntheses and drug design.
Proteomic Technologies and their Application for Ensuring Meat Quality, Safety and Authenticity
Authors: Banerjee Rituparna , Maheswarappa Naveena Basappa , Mohan Kiran , Biswas Subhasish , Batabyal Subhasish 
Published: January 2021

:Proteomic tools were extensively used to understand the relationship between muscle proteome and conversion of muscle to meat, post-mortem proteolysis, meat texture, and variation in meat color. Developments in proteomic tools have also resulted in their application for addressing the safety and authenticity issues including meat species identification, detection of animal byproducts, non-meat ingredients and tissues in meat products, traceability, identification of genetically modified ingredients, chemical residues and other harmful substances. Proteomic tools are also being used in some of the potential areas like understanding the effect of animal transportation, stunning, slaughter stress, halal authentication and issues related to animal welfare. Emerging advances in proteomic and peptidomic technologies and their application in traceability, meat microbiology, safety and authentication are taking a major stride as an interesting and complementary alternative to DNA-based methods currently in use. Future research in meat science need to be linked to emerging metabolomic, lipidomic and other omic technologies for ensuring integrated meat quality and safety management. In this paper, a comprehensive overview of the use of proteomics for the assessment of quality and safety in the meat value chain and their potential application is discussed.
Facile Synthetic Protocols for the Preparation of New Impurities in Pemetrexed
Disodium Heptahydrate as an Anti-cancer Drug
Authors: Jaggavarapu Rama Mohana Reddy , Muvvala Venkatanarayana , Ghojala Venkatareddy , Babu H. Sharath , Cheedarala Ravi Kumar 
Published: January 2021

Abstract:
A facile synthetic protocol was employed to prepare process-related impurities associated with the
synthesis of pemetrexed disodium heptahydrate, Alimta. The research work is described for the development of
the novel synthetic methods and their structure elucidation of Pemetrexed glutamide, N-methyl pemetrexed, and
N-methyl pemetrexed glutamide impurities. The listed impurities were deduced through spectral analysis, such as
1H-NMR, 13CNMR, and HRMS. The target compounds can be used as the reference substances for quality control.
Computational Bioactivity Analysis and Bioisosteric Investigation of the Approved Breast Cancer Drugs Proposed New Design Drug Compounds: Increased Bioactivity Coming with Silicon and Boron
Authors: Dogan Esma Eryilmaz 
Published: January 2021

Background:
The breast cancer takes the first place among women cancer diagnosed
worldwide.

Objective:
Based on the preferential multi-targeted approach on cancer therapy, we, in this study, aimed to design in silico
drug candidates possessing multi-targeted bioactivity to cope with multi-drug resistance using the known drug structures,
molecular modeling, and ADME parameters.

Materials and Methods:
We first evaluated the bioactivity score of the approved breast cancer drugs
across the top-three drug targets GPCR, kinase, and nuclear receptors and calculated their
physicochemical properties to see their drug-likeness profiles. Among 29 approved drugs, Aromasin
and Capecitabine showed the broadest bioactivity across the targets listed. By using molecular
modeling and bioisosteric modifications, and applying two filtering approaches, we investigated
thirty-one analogues of Aromasin and Capecitabine.

Results :
Software prediction resulted in that the compounds A14, C4, and C13 replaced with
B(OH)2 and/or Si(CH3)3 showed a broader spectrum of biological activity with a multi-targeted
manner than even the approved analogs.

Conclusion:
The interesting point of these new design molecules is to have either silicon and/or
boron incorporation. The increased bioactivity effect of Silicon and Boron incorporation is also seen
in the recently approved drug list of FDA and in clinical trials ongoing. Our new design boron and
silicon-based molecules appeared to be promising candidates for breast cancer treatment to be tested
in vitro, in vivo, and in the clinic for further pharmacological investigations.
Use of Paediatric Xylometazoline Nasal Drop is not a Child’s Play in Hypertensive Patients on Bisoprolol: A Case Report
Authors: Bhalla Hira , Gupta Abhishek , Patel Tejas 
Published: January 2021

Background:
Xylometazoline, a sympathomimetic agent, is considered safe in hypertensive
patients as a relief measure for nasal congestion with intranasal application.

Case Report::
In the present case, a 58-year old male patient, having ischemic heart disease, controlled
hypertension on telmisartan and bisoprolol, experienced hypertensive urgency in a span of
two hours of intranasal administration of the paediatric formulation of xylometazoline.

Conclusion:
The interaction with bisoprolol should be kept in mind while using xylometazoline.
PERBANDINGAN KOMPETENSI SOSIAL SISWA KOMUNITAS HOMESCHOOLING DENGAN SISWA REGULER SD MUHAMMADIYAH 1 SURAKARTA
Authors: Wijayarto Budi , Haryanto Haryanto 
Published: January 2021

Penelitian ini bertujuan untuk mengetahui perbedaan kompetensi sosial anak yang mengikuti model pendidikan homeschooling dan model pendidikan konvensional. Subjek dalam penelitian ini adalah siswa berusia 9-13 tahun, laki-laki dan perempuan. Teknik pengambilan data menggunakan metode angket. Adapun angket yang digunakan adalah skala kompetensi sosial yang disusun oleh peneliti sendiri dengan mengacu pada aspek-aspek yang dikemukakan oleh Frey & Bos (2012) hingga dihasilkan aitem sebanyak 24 aitem. Metode analisis data yang dilakukan dalam penelitian ini adalah dengan menggunakan fasilitas program SPSS 16.0 for Windows, untuk menguji apakah terdapat perbe-daan kompetensi sosial anak yang mengikuti model pendidikan homeschooling dan konvensional. Metode analisis data yang dilakukan dalam penelitian ini adalah dengan menggunakan fasilitas program SPSS 16.0 for Windows dengan Teknik Independent Samples T-tes. Hasil penelitian menunjukkan bahwa terdapat perbedaan kompetensi Sosial antara siswa homeschooling dengan siswa SD reguler, dimana siswa homeschooling lebih tinggi kompetensi sosialnya daripada siswa sekolah reguler. _________________________________________________________________________________________________________________________________________________ COMPARISON SOCIAL COMPETENCE BETWEEN HOMESCHOOLERS IN SOLO WITH REGULAR ELEMENTARY STUDENTS IN SD MUHAMMADIYAH 1, SOLO ABSTRACT The purpose of this research is to know the difference social competence between children that following homeshooling education model and regular education model. The subjects in this research were childrens with 9-13 of age, boys and/or girls. The data was collected using social competence scale that was made by writer also the items from aspects that was publicated by Frey and Bos (2012). The data was tested by using SPSS 16.0 for Windows, to know are there any differences of social competence between children that following homeschooling education model and regular. The data was tested by using SPSS 16.0 for Windows by The Independent Technic Samples T-test. Based on the test, there were any differences of social competence between children that following homeschooling education model and regular education model, in which the social competence of children that following homeschooling education model is higher than children that following regular education model. Keywords: social competence, homeschooling
PENGEMBANGAN BUKU PELAJARAN TEMATIK-INTEGRATIF BERBASIS NILAI KARAKTER DISIPLIN DAN TANGGUNG JAWAB DI SEKOLAH DASAR
Authors: Sari Indah Perdana , Syamsi Kastam 
Published: January 2021

Penelitian ini bertujuan untuk menghasilkan dan mengetahui keefektifan buku pelajaran tematik-integratif dengan tema “Mari Bermain Sambil Berolahraga” berbasis nilai karakter disiplin dan tanggung jawab untuk peserta didik kelas III SD. Penelitian ini merupakan penelitian dan pengembangan (R&D) dengan model Brog & Gall. Uji coba produk melibatkan 67 peserta didik kelas III SD 2 Padokan Bantul. Hasil penelitian menunjukkan buku pelajaran yang dikembangkan dari aspek kelayakan isi berkategori “sangat baik”, aspek kebahasaan berkategori “sangat baik”, aspek penyajian berkategori “sangat baik”, dan aspek kegrafikaan berkategori “sangat baik”. Hasil untuk nilai karakter disiplin menunjukkan uji-t= -3,110 dengan P sebesar 0,000 dan nilai karakter tanggung jawab menunjukkan hasil uji-t= -4,440 dengan P sebesar 0,003. Selain itu, nilai hasil belajar menunjukkan 100% peserta didik tuntas dalam pembelajaran. ________________________________________________________________________________________________________________________________________________________ DEVELOPMENT THEMATIC-INTEGRATIF TEXTBOOKS BASED ON DISCIPLINE AND RESPONSIBILITY VALUES IN ELEMENTARY SCHOOLABSTRACT This study aims to: produce and determine the effectiveness of thematic-integrative textbooks with the theme of "Let's Play while Exercising" based on discipline and responsibility values. This study is a Research and Development (R & D) with a Brog and Gall model. The tryout involved 67 students of grade III in Padokan Bantul Elementary School 2. This is evidenced by the results of expert evaluation showing the textbooks developed is terms of the feasibility contents category is "very good", aspects of language category is "very good", aspects of presentation category is "very good", and aspect of grapichlly category is "very good". As for discipline value results of t-test = -3.110 with P values of 0.000 and the value of responsibilities results of t-test = -4.440 with P values 0.003. Moreover, the data of the learning result show is 100% learning mastery. Keywords: textbooks, thematic-integrated, discipline value, responsibiliy value