bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Kepemimpinan K.H Wahid Hasyim Terhadap Reformasi Pendidikan Pesantren
Authors: Kurohman M. Taofik , Wahyuni Anny , Purnomo Budi 
Published: November 2021

K.H. Abdul Wahid Hasyim is one of the founding fathers of the Indonesian nation. His services, thoughts and dedication to Indonesia are unquestionable. With his family background and education, he has a visionary ambition to change the conservative education system in pesantren and of course by not leaving religious education as his priority. This paper tries to describe Wahid Hasyim's biography and examines his various thoughts on education as well as the content of his vision of reforming pesantren education.
K.H. Abdul Wahid Hasyim merupakan salah satu bapak pendiri bangsa Indonesia. Jasa, pemikiran dan pengabdiannya untuk Indonesia tak perlu dipertanyakan lagi. Dengan latar belakang keluarga dan pendidikannya membuat ia mempunyai ambisi yang visioner untuk mengubah sistem pendidikan yang konservatif di pesantren dan tentu saja dengan tidak meninggalkan pendidikan keagamaan yang diutamakan. Tulisan ini mencoba menguraikan biografi Wahid Hasyim dan menelaah berbagai pemikirannya mengenai pendidikan dan juga isi dari visi nya mereformasi pendidikan pesantren.
Clinical Evaluation of Acanthosis Nigricans and Its Correlation with Endocrine, Metabolic and Nutritional Factors in Gujarat,India
Authors: Sohan A Patel  , Jayant B Dave  , Timir Y Mehta  
Published: November 2021

Acanthosis nigricans (AN) refers to the velvety, black hyperpigmentation in flexures usually on the neck and axillae. AN is associated with multiple endocrinopathies and insulin resistance is reported to be a common denominator among them. The aim of the study was to identify the correlation of metabolic factors (Serum glucose, lipid profile), endocrine factors (TSH, serum insulin), and nutritional factors (vitamin B12, Ferritin) in AN patients in Aravalli district of Gujarat state. A total of Seventeen Patients (11 male and 6 female) were included in the study History, clinical observations, physical parameters, and biochemical tests were noted in AN patients and correlation of some likely factors with AN was explored. The age was 28.41±15.09 years for AN group and 35.45±8.74 years for control group. The mean BMI was found to be higher in AN at 1 % level of significance (P = 0.007) implying that overweight/obesity is associated with AN. The mean TSH value was found to be higher in AN than control group at 5 % level of significance (P = 0.0115) implying that hypothyroidism (elevated TSH value) is associated with AN. The 45.45 % patients had higher blood glucose levels and some of the patients had higher level of insulin. The mean lipid profile, vitamin B12 and serum ferritin were found to be at non-significance level. All statistical tests were performed using graph pad prism software (version 5.0). Positive correlations were observed between higher fasting glucose and hyperinsulinemia with AN and others factors such as metabolic and endocrine like overweight/obesity, hypothyroidism, higher glucose and serum insulin with AN. This implies that AN can serve as a marker for detecting hyperinsulinemia and hypothyroidism. Some of the parameters like, Serum lipid profile, vitamin B12 and ferritin levels could not be correlated to AN. Thus, patients with AN can be targeted for lifestyle and behavioral modifications at an early stage to avoid the serious consequences of AN.
Assessing Airway Resistance Using Plethysmography as Lung Function Testing Among Asymptomatic Rheumatoid Arthritis Patients.
Authors: Abdulrhman Mustafa Rasheed  , Ahmed Fadlalla  , Tarig Fadelelmoula  , Alblowi, Wael F  , Saitah Fawaz Alshammari  , Asmaa Hegazy  
Published: November 2021

Pulmonary events in rheumatoid arthritis (RA) reflects the involvement of pleurae, lung interstitium, and airways. Overall, pulmonary manifestations are estimated to cause 10–20% of mortalities in RA. Respiratory system involvement as extra-articular presentations of RA is common among some Saudi patients. This study aims to evaluate specific airway conductance (sGaw), airway resistance (Raw), and specific airway resistance (sRaw), using plethysmography. Comparison for deployed methods is made by forced spirometer as an indicator for obstruction among patients with RA. The study sought to use the methods to enhance lung testing among RA patients. An analytical, hospital-based study was carried out at pulmonary function test laboratory, department of respiratory care King Saud Medical City (KSMC). RA patients were selected, with an age group of 18-75years. The tests for Forced spirometer and plethysmography were carried out to assess and analyze how the respiratory mechanism was impacted by the disease. Data collected was analyzed using Statistical Package for Social Sciences (SPSS), version 21. The obstructive and mixed ventilation patterns constituted 15%; the mean values of Raw and sRaw were significantly higher compared to mean values predicted for participants selected during the study, while sGaw was significantly lower compared to mean values predicted for participants selected. Monitoring of airway resistance parameters using plethysmography can be used as indicators of lung function testing among RA patients.
Reabsorções dentárias internas
Authors: Milano Nicolau F. , Ebling Hardy , D. Barbachan João Jorge 
Published: November 2021

The mechanism of action of the so-called internal resorption of dentine is only one, either internal or external. Resorption can be produced
by pathological causes. It is stressed how important is the precocious
diagnosis. Radiographic diagnosis is commented. It is suggested the treatment by pulpectomy. The prognosis depends upon the resorption extension area.
Lo stato di qualità dei corpi idrici superficiali: classificazione ed analisi dei trend degli elementi LIMeco per Mingardo, Tusciano e Regi Lagni
Authors: Comarco Davide 
Published: November 2021

Lo scopo del presente elaborato è analizzare i trend dei parametri
chimico-fisici che rientrano nella classificazione di un fiume. Questi,
abbinati ad altri parametri concorrono alla determinazione finale dello
Stato ecologico.
Per la classificazione dello stato ecologico dei corpi idrici fluviali
gli elementi fisico-chimici a sostegno del biologico da utilizzare sono
costituiti dai nutrienti di cui fanno parte l’azoto ammoniacale, l’azoto
nitrico ed il fosforo totale oltre all’ossigeno disciolto.
Rispetto a tali elementi sono stati creati dei grafici che
raffigurassero l’andamento temporale e l’andamento spaziale dei vari
fiumi, partendo dai primi campionamenti avvenuti all’inizio degli anni
2000.
L’obiettivo è quello di analizzare i monitoraggi avvenuti degli elementi
sopra citati per avere un quadro efficace e chiaro dello stato di
qualità dei corpi idrici superficiali, nel suddetto caso fiumi Campani
ma l’analisi può e dev’essere estesa anche all’interno reticolo
idrografico italiano.
Prediction of activity of CRISPR-Cpf1 guide RNA via in vivo high-throughput screening
Authors: wang gancheng , zhu dan , li juan , wang junyi , xi jianzhong 
Published: November 2021

Background: CRISPR-cpf1 is a single RNA-guided endonuclease system,
becoming a promising tool in both prokaryotic and eukaryotic genome
engineering. The editing efficiency of Cpf1 based engineering still
requires improvements. However, limited information regarding the
relationship between guide RNA sequence and on-target activity is
available. To address these challenges, we developed a screening
platform based on the association of Acidaminococcus sp. Cpf1(AsCpf1)
DNA cleavage with cellular lethality. Major results: In total, we
measured the activities of 12,544 guide RNAs, and observed a substantial
variation of the editing efficiency depending on the design of the
sequence. Based on this large-scale dataset, we designed and implemented
a comprehensive computational model to predict activities of guide RNAs.
Through comparison using simulated and experimental data, our approach
outperformed existing algorithms, enabling selection of efficient guide
RNAs. Conclusions: We refine on-target design rules and isolate the
important sequence features that contribute to DNA cleavage, that is, AH
dimers at position1-8 of protospacer promoting Cas12a activity while TK,
GB dimer playing an inhibitory role. We validate guide RNA affinities
designed by our optimized rules in both E.coli and 293T cells.
Circulating Metabolites and the Development of Type 2 Diabetes in Chinese Adults
Authors: Bragg Fiona , Kartsonaki Christiana , Guo Yu , Holmes Michael , Du Huaidong , Yu Canqing , Pei Pei , Yang Ling , Jin Donghui , Chen Yiping , Schmidt Dan , Avery Daniel , Lv Jun , Chen Junshi , Clarke Robert , Hill Michael , Li Liming , Millwood Iona , Chen Zhengming 
Published: November 2021

OBJECTIVETo assess prospective associations of circulating metabolites with the risk of type 2 diabetes (T2D) among Chinese adults.RESEARCH DESIGN AND METHODSA case-cohort study within the 8-year prospective China Kadoorie Biobank comprised 882 participants with incident T2D and 789 subcohort participants. Nuclear magnetic resonance metabolomic profiling quantified 225 metabolites in stored baseline plasma samples. Cox regression related individual metabolites with T2D risk, adjusting for potential confounders and fasting time.RESULTSAfter correction for multiple testing, 163 metabolites were significantly associated with the risk of T2D (P &lt; 0.05). There were strong positive associations of VLDL particle size, the ratio of apolipoprotein B to apolipoprotein A-1, branched-chain amino acids, glucose, and triglycerides with T2D, and inverse associations of HDL-cholesterol, HDL particle size, and relative n-3 and saturated fatty acid concentrations.CONCLUSIONSIn Chinese adults, metabolites across diverse pathways were independently associated with T2D risk, providing valuable etiological insights and potential to improve T2D risk prediction.
Evidence That Hypothalamic Gliosis Is Related to Impaired Glucose Homeostasis in Adults With Obesity
Authors: Rosenbaum Jennifer L. , Melhorn Susan J. , Schoen Stefan , Webb Mary F. , De Leon Mary Rosalynn B. , Humphreys Madelaine , Utzschneider Kristina M. , Schur Ellen A. 
Published: November 2021

OBJECTIVE
Preclinical research implicates hypothalamic glial cell responses in the pathogenesis of obesity and type 2 diabetes (T2D). In the current study we sought to translate such findings to humans by testing whether radiologic markers of gliosis in the mediobasal hypothalamus (MBH) were greater in individuals with obesity and impaired glucose homeostasis or T2D.

RESEARCH DESIGN AND METHODS
Using cross-sectional and prospective cohort study designs, we applied a validated quantitative MRI approach to assess gliosis in 67 adults with obesity and normal glucose tolerance, impaired glucose tolerance (IGT), or T2D. Assessments of glucose homeostasis were conducted via oral glucose tolerance tests (OGTT) and β-cell modeling.

RESULTS
We found significantly greater T2 relaxation times (a marker of gliosis by MRI), that were independent of adiposity, in the groups with IGT and T2D as compared with the group with normal glucose tolerance. Findings were present in the MBH, but not control regions. Moreover, positive linear associations were present in the MBH but not control regions between T2 relaxation time and glucose area under the curve during an OGTT, fasting glucose concentrations, hemoglobin A1c, and visceral adipose tissue mass, whereas negative linear relationships were present in the MBH for markers of insulin sensitivity and β-cell function. In a prospective cohort study, greater MBH T2 relaxation times predicted declining insulin sensitivity over 1 year.

CONCLUSIONS
Findings support a role for hypothalamic gliosis in the progression of insulin resistance in obesity and thus T2D pathogenesis in humans.
Data Harmonization and Data Pooling from Cohort Studies: A Practical Approach for Data Management
Authors: Adhikari Kamala , Patten Scott B , Patel Alka B , Premji Shahirose , Tough Suzanne , Letourneau Nicole , Giesbrecht Gerald , Metcalfe Amy 
Published: November 2021

Data pooling from pre-existing multiple datasets can be useful to increase study sample size and statistical power to answer a research question. However, individual datasets may contain variables that measure the same construct differently, posing challenges for data pooling. Variable harmonization, an approach that can generate comparable datasets from heterogeneous sources, can address this issue in some circumstances. As an illustrative example, this paper describes the data harmonization strategies that helped generate comparable datasets across two Canadian pregnancy cohort studies– the All Our Families and the Alberta Pregnancy Outcomes and Nutrition.
Variables were harmonized considering multiple features across the datasets: the construct measured; question asked/response options; the measurement scale used; the frequency of measurement; timing of measurement, and the data structure. Completely matching, partially matching, and completely un-matching variables across the datasets were determined based on these features. Variables that were an exact match were pooled as is. Partially matching variables were synchronized across the datasets considering the frequency of measurement, the timing of measurement, and response options. Variables that were completely unmatching could not be harmonized into a single variable.
The variable harmonization strategies that were used to generate comparable cohort datasets for data pooling are applicable to other data sources. Future studies may employ or evaluate these strategies. Variable harmonization and pooling provide an opportunity to increase study power and the utility of existing data, permitting researchers to answer novel research questions in a statistically efficient, timely, and cost-efficient manner that could not be achieved using a single data source.
HUBUNGAN TINGKAT KREATIVITAS DENGAN HASIL BELAJAR MATA PELAJARAN GAMBAR TEKNIK
Authors: Syahri Budi , Syahrial Syahrial 
Published: November 2021

Kreativitas siswa merupakan salah satu faktor yang diduga berhubungan terhadap keberhasilan belajar siswa karena siswa yang kreatif jarang menghadapi masalah dalam belajar. Dilihat dari nilai hasil belajar siswa mata pelajaran Gambar Teknik masih banyak nialai siswa di bawah KKM yaitu 75 dengan rentang nilai 0 - 100.Penelitian ini bertujuan untuk mengetahui hubungan tingkat kreativitas siswa terhadap hasil belajar mata pelajaran Gambar Teknik kelas XI Teknik Pemesinan SMK Negeri 1 Bukittinggi. Dalam penelitian ini terdapat dua variabel yaitu kreativitas siswa sebagai variabel X dan hasil belajar siswa sebagai variabel Y.
Penelitian ini merupakan penelitian korelasional dengan populasi 42 orang siswa. Teknik pengumpulan data menggunakan instrument angket yang sudah di uji validitas dan reabilitasnya, kemudian mencatat hasil belajar siswa. Analisis Tingkat Pencapaian Responden dengan rumus persentase dan skor rata-rata hasil belajar, uji persyaratan analisis dengan uji normalitas dan uji linieritas, analisis koefisien korelasi dengan korelasi Product Moment sebagai uji hipotesis. Data yang dikumpul tersebut dianalisis dengan bantuan komputer program SPSS versi 16.00 for windows.
Uji coba instrument penelitian dilakukan kepada siswa yang di luar sampel penelitian. Untuk menentukan validitas angket menggunakan program SPSS dengan taraf signifikansi 5% diperoleh pernyataan yang gugur sebanyak 7 item. Hasil penelitian, diperoleh harga koefesien korelasi sebesar 0,517 artinya kreativitas mempunyai hubungan yang positif dan berarti terhadap hasil belajar Gambar Teknik, dengandemikian Semakin tinggikreativitassiswa maka semakin tinggi pula hasil belajar Gambar Teknik, dengan kategori interpretasi koefisien korelasi Cukup Kuat.
PENGARUH PENGGUNAAN MODUL PEMBELAJARAN TERHADAP HASIL BELAJAR MATA PELAJARAN GAMBAR TEKNIK KELAS X JURUSAN TEKNIK PEMESINAN DI SMK NEGERI 1 PADANG
Authors: Khardin Alvien , Suparno Suparno , Primawati Primawati , K Arwizet , Refdinal Refdinal , Yufrizal Yufrizal 
Published: November 2021

Tujuan dilaksanakan penelitian ini adalah untuk: (1) mengetahui tahapan pembuatan dan pengembangan modul pembelajaran yang tepat pada mata pelajaran gambar teknik kelas X jurusan teknik mesin SMK/MAK; (2) mengetahaui kelayakan modul melalui uji validitas; (3) mengetahui kepraktisan modul melalui uji praktikalitas; (4) mengetahui efektivitas modul melalui uji efektivitas.
Penelitian ini merupakan penelitian Research and Development (R & D) yang menggunakan model pengembangan dari Plomp (2013). Penelitian ini dilaksanakan di SMK Negeri 1 padang. Subjek penelitian adalah siswa kelas X jurusan teknik pemesinan SMK Negeri 1 Padang. Pengumpulan data menggunakan angket dan tes. Tes menggunakan pre test dan post test untuk memperoleh data efektivitas. Analisis menggunakan pendekatan kualitatif dan kuantitatif.
Penelitian ini menghasilkan produk berupa modul gambar teknik untuk siswa kelas X jurusan teknik mesin SMK/MAK. Penilaian modul pembelajaran meliputi validitas ahli materi, validitas ahli media, uji one to one, uji kelompok kecil (small group), uji praktikalitas oleh guru, uji praktikalitas oleh 32 siswa, uji pemakaian oleh 32 siswa. Validasi ahli materi mendapatkan pesentase 80,71% dengan kategori sangat layak, validasi ahli media mendapatkan persentase 84,38% dengan kategori sangat layak, uji one to one mendapatkan persentase 100 % dengan kategori sangat praktis. Uji small group mendapatkan persentase 100% dengan kategori sangat praktis, uji praktikalitas oleh guru mendapatkan persentase 95 % dengan kategori sangat praktis, uji praktikalitas oleh 32 siswa mendapatkan persentase 90,63 % dengan kategori sangat layak, dan uji pemakaian oleh 32 siswa menunjukkan ada peningkatan hasil belajar setelah menggunakan modul gambar teknik.
Kata Kunci : Modul Pembelajaran, Hasil Belajar, Gambar Teknik
HUBUNGAN ANTARA PERSEPSI SISWA TENTANG KETERAMPILAN GURU PPLK DENGAN DISIPLIN BELAJAR KELAS X TEKNIK MESIN DI SMK NEGERI 1 SUMATERA BARAT
Authors: Putra Bima Afrindo , Waskito Waskito , Mulianti Mulianti , Rifelino Rifelino 
Published: November 2021

Penelitian ini membahas tentang hubungan antara persepsi siswa tentang keterampilan guru pplk dengan disiplin belajar. Tujuan penelitian ini adalah untuk mendeskripsikan persepsi siswa tentang keterampilan guru PPLK.Jenis penelitian ini adalah penelitian deskriptif korelasional, yang berkaitan dengan pengumpulan data untuk memberikan gambaran atau penegasan suatu konsep atau gejala, guna menjawab pertanyaan yang akhirnya dapat mengambil suatu kesimpulan umum dari realita yang ada. Dengan mengumpulkan informasi mengenai status suatu gejala yang ada, yaitu keadaan gejala menurut apa adanya pada saat penelitian dilakukan. Penelitian ini mengambil lokasi di SMK Negeri 1 Sumatera Barat. Analisis data penelitian ini menggunakan teknik korelasi regresi. Analisis korelasi regresi dilakukan dengan bantuan program komputer.Berdasarkan hasil penelitian dan pembahasan yang telah diuraikan pada bab sebelumnya, maka diperoleh kesimpulan sebagai berikut: Deskripsi variabel (X) Persepsi Siswa Tentang Keterampilan Guru PPLKdidapatkan Mean : 85.2143, Median : 85.0000, Modus : 84.00 dan Standar Devisiasi : 1.45729. Deskripsi variabel (Y) Disiplin Belajar Siswadidapatkan Mean : 47.0952, Median : 47.0000, Modus : 47.00a dan Standar Devisiasi : 1.14358. Terdapat hubungan atau kolerasipositif Persepsi Siswa Tentang Keterampilan Guru PPLK dengan Disiplin Belajar Siswa Kelas X Teknik Mesin di SMK Negeri 1 Sumatera Barat yaitu 0,339.
Kata Kunci :Hubungan, Persepsi, Siswa, Keterampilan Guru, Disiplin Belajar
ANALISIS PENGARUH VARIASI KUAT ARUS PENGELASAN METAL INERT GAS (MIG)	TERHADAP KETANGGUHAN MATERIAL SAMBUNGAN LAS PADA BAJA ST 37
Authors: Priyono Budi , Irzal Irzal , Nurdin Hendri , Primawati Primawati 
Published: November 2021

Penelitian ini bertujuan untuk menganalisis pengaruh dari variasi kuat arus pengelasan terhadap ketangguhan dari hasil pengelasan MIG (Metal Inert Gas) dengan kawat las ER 70S 6 (AWS A5.18) berdiameter 1,2 mm pada baja karbon rendah ST 37 dengan ketebalan10 mm menggunakan pengujian Impak Charpy ASTM E 23. Metode yang digunakan pada penelitian ini adalah metode eskperimen. Penelitian ini bertujuan untuk mengetahui pengaruh variasi kuat arus pengelasan terhadap impak hasil pengelasan MIG baja ST 37 dengan variasi kuat arus pengelasan 120 A, 140 A, dan 160 A. Hasil dari pengujian Impak Charpy ini yaitu spesimen kontrol atau tanpa pengelasan hasil uji impact Charpy memiliki nilai harga Impact rata-rata sebesar 2,04 Joule/mm2, spesimen dengan pengelasan kuat arus 120 Ampere memiliki nilai harga Impact rata-rata sebesar 2,15 Joule/mm2 spesimen dengan pengelasan kuat arus 140 Ampere memiliki nilai harga Impact rata-rata sebesar 2,20 Joule/mm2, impact spesimen dengan pengelasan kuat arus 160 Ampere memiliki nilai harga Impact rata-rata sebesar 1,99 Joule/mm2, Berdasarkan dari pengujian Impact Charpy hasil pengelasan MIG (Metal Inert Gas) dengan variasi kuat arus pengelasan 120 A, 140 A, dan 160 A dapat diambil kesimpulan bahwa dari hasil yang didapatkan terjadi perbedaan ketanguhan material dalam menyerap energi dari beban kejut yang mengenainya begitu juga dengan harga impak pada setiap spesimen terhadap variasi arus yang diberikan. Perbedaan ini terjadi karena pengaruh panas yang terjadi pada material semakin meningkat sesuai dengan kuat arus yang diterima oleh material hasil las MIG sehingga hal ini berpengaruh pada struktur material yang dilas sehingga membuat ketangguhan dan harga impak dari masing-masing spesimen yang didapat menunjukkan hasil yang berbeda.
ANALISIS KECEPATAN AIR MASUK TERHADAP BUKAAN GUIDE VANE TURBIN CROSSFLOW SKALA PICO HYDRO DENGAN SIMULASI CFD
Authors: Riadi Dimas , Lapisa Remon , Nurdin Hendri , Mulianti Mulianti 
Published: November 2021

Turbin Ossberger atau yang biasa dikenal dengan turbin Cross-flow adalah type turbin bertekanan yang kerap dipakai pada PLTA. Contohnya adalah pembangkit listrik tenaga pico hydro. Kenagarian Koto Hilalang di Kabupaten Solok Kecamatan Kubung, Sumatera Barat merupakan salah satu contoh lokasi dimana Pembangkit Listrik Tenaga pico hydro dapat digunakan sebagai sumber tenaga. Penelitian ini dilakukan untuk menganalisis akibat dari variasi guide vane pada turbin jenis cross-flow yang dimanfaatkan sebagai pembangkit listrik tenaga pico hydro dengan daya yang dihasilkan sebesar 31,85 Kw. Dengan adanya penelitian ini dapat menentukan kecepatan magnitude air terhadap variasi bukaan guide vane untuk meningkatkan efisiensi turbin. Metode dalam pelaksanaan penelitian ini yaitu simulasi Computational Fluid Dynamic (CFD) dilakukan pada perangkat lunak Autodesk CFD dengan model turbulens k-ipsilon. Tahapan dalam melaksanakan simulasi CFD ini yakni dengan memvariasikan bukaan guide vane dengan variasi 25%, 50%, 75%, 100%. Hasil analisis pada simulasi CFD menunjukan bahwa kecepatan maksimal berada pada bukaan 25% yang menghasilkan kecepatan masuk sebesar 112,79 m/s pada parametric distance 32, simulasi ini menunjukan kecepatan masuk air mengalami penurunan. Kecepatan masuk air pada simulasi ini di buat tetap dengan sebesar 11,72 m/s dan dalam keadaan steady state.