bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KEMUDAHAN DAN PEMAHAMAN PENGGUNAAN SISTEM E-FILING TERHADAP KEPATUHAN WAJIB PAJAK ORANG PRIBADI DALAM MELAPORKAN SPT TAHUNAN DI KABUPATEN BEKASI
Authors: Widyaningsih Dian Rizki , Siringoringo Whereson 
Published: December 2021

Kepatuhan Wajib Pajak Orang pribadi merupakan hal yang mutlak diperlukan dalam pencapaian target pendapatan negara dari sektor pajak. Salah satu bentuk kepatuhan WPOP adalah melalui pelaporan SPT tahunan baik secara langsung maupun melalui e-filing. E-filing merupakan media penyampaian SPT secara daring yang sesuai dengan perkembangan teknologi dan internet saat ini. Penelitian ini bertujuan untuk mengetahui pengaruh kemudahan dan pemahaman dalam penggunaan e-filing terhadap Kepatuhan WPOP di Kabupaten Bekasi. Metode penelitian yang digunakan adalah dengan pendekatan kuantitatif dengan analisis menggunakan regresi linear berganda. Data primer diperoleh dengan menggunakan kuesioner dengan responden berasal dari populasi Wajib Pajak Orang Pribadi di Kabupaten Bekasi dengan jumlah sampel sebanyak 100 responden. Hasil analisis secara parsial menunjukkan bahwa variabel kemudahan dan pemahaman dalam penggunaan e-filing berpengaruh positif terhadap Kepatuhan WPOP. Hasil penelitian ini diharapakan menjadi masukan bagi berbagai pihak untuk menyempurnakan media e-filing sehingga tingkat kemudahan penggunaan lebih baik dan pemahaman pengguna semakin baik untuk menciptakan kepatuhan yang lebih baik lagi.

Kata Kunci: Kemudahan, Pemahaman, e-filing, SPT, Kepatuhan WPOP.
Towards a Bilingual Binational Translation Method: The Amputated Tongue Collection of Short Stories as a Sample
Authors: Burbara Rawiya 
Published: December 2021

Translators and writers are divided into two main groups regarding the method of translation that should be adopted in translating texts. One group believes that the translator should be true to the translated text, while the other group believes that the translator has the right to recreate the text into a more beautiful one. This study deals with this issue from these two points of view and tries to answer the following questions: Why do we translate? What should we translate? How do we translate? The study relies on an innovative translation method developed by the Board of Maktoub Project for Translation that belongs to Van Leer Institute in Jerusalem to answer these questions. A group of about one hundred Arab and Jewish translators translated Arabic literature texts into Hebrew in an internationally new method, which is neither individual nor collective. It is a bilingual binational method. The translators consist of pairs of a Jewish or/and Arab translator, an Arab/or Jewish literary editor, and a linguistic editor, believing that translation is a text and culture, heritage, and traditions of a people or nation. This dual method gave the translated text its right of accuracy after it had been translated by one translator who can make mistakes due to his ignorance of the writer's culture. The study's conclusion confirms that bilingual binational translation is more fruitful and more accurate because it is based on dialogue, bilingual, and binational cultural knowledge.
Dynamic fusion of images from the visible and infrared channels of sightseeing system by complex matrix formalism
Authors: Khaustov D. , Khaustov Ya. , Ryzhov Ye. , Burashnikov O. , Lychkovskyy E. , Nastishin Yu. 
Published: December 2021

The employment of new mathematical and computer approaches for the fusion of target images from the visible and infrared channels of the sightseeing system (SSS) is one of the ways to increase the efficiency of the SSS of armored vehicles. Modern approaches to improving the efficiency of image fusion are aimed to increase the visibility of the target via improving the quality indices of fused images. This paper proposes a fundamentally new approach to image fusion, namely dynamic image fusion, at which the target is observed in the mode of a video clip composed of a sequence of stationary fused images obtained at different parameters of fusion, in contrast to traditional stationary image fusion, at which the decision is made from one fused image. Unlike stationary image fusion, aimed to increase the visibility of the target, the dynamic image fusion allows one to enhance the conspicuity of the target. The principle of dynamic image fusion proposed in this paper is based on matrix formalism, in which the fused image is constructed in the form of a complex vector function, which by its mathematical form is analogous to the Jones vector of elliptically polarized light wave, which in turn opens the possibility of matrix transformation of the complex vector of the fused image and consequently its parameterization by analogy with the Jones matrix formalism for the light wave. The article presents mathematical principles of matrix formalism, which is the basis for dynamic image fusion, gives examples of stationary and dynamic image fusion by the method of complex vector function and compares with the corresponding images, fused by algorithms of weight addition in the field of real and complex scalars. It is shown that by selecting weight coefficients, the general form of a complex amplitude vector image can be reduced to the algorithms of weight and averaged addition in the field of real scalars, weight amplitude and RMS-image in the field of complex scalar numbers, and geometric-mean image in the field of complex vectors, which, thereby, are partial cases of the general form of the complex amplitude image in the field of complex vectors.
The animated images obtained by the method of complex vector function illustrate the increase of conspicuity of the object of observation due to the dynamic change of the fusion parameters.
Analysis of Ocular Biometric Parameters in Patients with Cystoid Macular Edema
Authors: Gorbunova N. Yu. , Voskresenskaya A. A. , Yakovlev R. A. , Pozdeeva N. A. 
Published: December 2021

Relevance. Cataract surgeries are among the most frequently performed ophthalmic surgeries in the world. Despite the fact that they become less traumatic every year, such interventions are still accompanied by post-surgery complications, one of which is cystic macular edema (CME) or Irwin–Gass syndrome. Purpose. To analyze ocular biometric parameters in patients with CME. Material and Methods. The study included 40 patients (40 eyes) with post-surgery CME. All patients underwent ultrasound biometry, axial length measurement, crystalline lens thickness measurement with Bio&Pachy Meter AL-4000 (Tomey, Japan) and optical coherence tomography (OCT) with Cirrus HD-OCT 5000 (Carl Zeiss, Germany) to assess central foveal thickness. Depending on the axial length, all eyes were divided into “long” and “short” relative to the average axial length of 23.3 mm. The data was analyzed with STATISTICA 10 software (StatSoft Inc., USA). Results. The incidence of CME after uncomplicated cataract surgery in Cheboksary branch of the S. Fyodorov Eye Microsurgery Federal State Institution amounted to 0.002%. Axial length among patients with CME ranged from 20.53 mm to 25.4 mm; the average value amounted to 22.67 ± 1.05 mm. The majority of eyes were “short” – 31 eyes (77.5%), whereas 9 eyes (22.5%) were “long”. “Short” eyes exhibited a greater crystalline lens thickness (4.81 ± 0.53 mm) compared to “long” eyes (4.42 ± 0.42 mm) (рM-U = 0.014). Conclusion. The development of CME after uncomplicated cataract surgery is more often observed in eyes with axial length smaller than 23.3 mm.
Adenocarcinoma de vulva: un reporte de caso tipo glándula mamaria
Authors: Alarcon Andrade Carlos , Rivadeneira Santana Nery , Montes Lainez Hector Daniel 
Published: December 2021

Introducción: Los tumores malignos de vulva son tumores raros del tracto genital femenino, que representan menos del 1 % de los tumores malignos del sexo femenino, cerca del 95% de estos son carcinoma escamo celulares, los adenocarcinomas son el tipo histológico menos frecuente, con 36 casos reportados hasta el año 2020.
Caso Clínico: Presentamos el caso de una mujer de 36 años con antecedente de histerectomía total por miomatosis, con cuadro clínico de 1 año de evolución caracterizado por una masa indolora en labio mayor izquierdo la cual se somete a biopsia que reporta adenocarcinoma motivo por el cual se somete a vulvectomia radical, en resultado patológico definitivo se confirma el diagnostico de adenocarcinoma de vulva tipo glándula mamaria.
Evolución: Se realiza vulvectomía radical + vaciamiento ganglionar inguino-iliaco bilateral. El estudio histo-patológico definitivo reveló adenocarcinoma de vulva tipo glándula mamaria pobremente diferenciado G3, Unifocal, con metástasis en 22/25 ganglios derechos y 30/30 izquierdos. Un estudio reportó recidiva local extensa, metástasis ganglionares pélvicas, retroperitoneales, mediastinales, axilares, cervicales y pulmonar. Se inició Paclitaxel 137 mg semanal. Se completa quimioterapia hasta 11ra semana posterior a lo cual presentó infección de lecho tumoral y fallece.
Conclusión: En el presente caso el curso clínico de adenocarcinoma de vulva tipo glándula mamaria fue agresivo con una supervivencia inferior a 5 meses.
A Supramolecular Nanoparticle of Pemetrexed Improves the Anti-Tumor Effect by Inhibiting Mitochondrial Energy Metabolism
Authors: Liu Hui , Guo Chunlei , Shang Yuhong , Zeng Lin , Jia Haixue , Wang Zhongyan 
Published: December 2021

In recent years, supramolecular nanoparticles consisting of peptides and drugs have been regarded as useful drug delivery systems for tumor therapy. Pemetrexed (PEM) is a multitarget drug that is effective for many cancers, such as non-small cell lung cancer. Here, RGD-conjugated molecular nanoparticles mainly composed of an anticancer drug of PEM (PEM-FFRGD) were prepared to deliver PEM to tumors. The peptide could self-assemble into a nanoparticle structure with diameter of about 20 nm. Moreover, the nanoparticle showed favorable solubility and biocompatibility compared with those of PEM, and the MTT test on A549 and LLC cells showed that the PEM-FFRGD nanoparticles had stronger cytotoxic activity than PEM alone. Most importantly, the nanoparticle could promote tumor apoptosis and decrease mitochondrial energy metabolism in tumors. In vivo studies indicated that PEM-FFRGD nanoparticles had enhanced antitumor efficacy in LLC tumor-bearing mice compared to that of PEM. Our observations suggested that PEM-FFRGD nanoparticles have great practical potential for application in lung cancer therapy.
CHNQD-00603 Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by the miR-452-3p-Mediated Autophagy Pathway
Authors: Xin Shanshan , Li Shao-Ming , Gao Ling , Zheng Jing-Jing , Wu Yan-Wei , Shao Chang-Lun , Ren Wen-Hao , Zhi Keqian 
Published: December 2021

Background: Periodontitis is a chronic and progressive disease accompanied by bone loss. It is still a challenge to restore the bone structure. The osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a decisive role in bone restoration and regeneration. Marine natural products (MNPs) have multiple biological activities, including anti-tumor and anti-inflammatory properties. However, the exploration of MNPs in osteogenesis is far from sufficient.Methods: We obtained a series of derivatives through structural optimization from 4-phenyl-3,4-dihydroquinolin-2(1H)-one alkaloid isolated from Scopulariopsis sp. Some preliminary cytological experiments showed that CHNQD-00603, obtained by adding a methoxy group to the position C3 and a hydroxyl group to the position C4 of 4-phenyl-3,4-dihydroquinolin-2(1H)-one, might promote the osteogenic differentiation of BMSCs. To further investigate the effects of CHNQD-00603 on BMSCs, we performed a CCK-8 assay and qRT-PCR, alkaline phosphatase staining (ALP), and alizarin red S staining to assess the cytotoxicity and the ability of osteogenic differentiation of CHNQD-00603. The autophagy level was assessed and validated by WB, qRT-PCR, and transmission electron microscopy. Then, 3-methyladenine (3-MA) was added to further examine the role of autophagy. Based on the expression of autophagy-related genes, we predicted and examined the potential miRNAs by bioinformatics.Results: CCK-8 assay showed that CHNQD-00603 at 1 µg/ml did not influence BMSCs activity. However, the proliferation rate decreased from the seventh day. qRT-PCR, ALP staining, ALP activity assay, and Alizarin red S staining showed that the best concentration of CHNQD-00603 to promote osteogenic differentiation was 1 µg/ml. Further investigations indicated that CHNQD-00603 activated autophagy, and the inhibition of autophagy by 3-MA attenuated CHNQD-00603-enhanced osteogenic differentiation. Subsequently, the findings from bioinformatics and qRT-PCR indicated that miR-452-3p might be a regulator of autophagy and osteogenesis. Furthermore, we transfected BMSCs with miR-452-3p NC and mimics separately to further determine the function of miR-452-3p. The data showed that the overexpression of miR-452-3p moderated the level of autophagy and osteogenic differentiation of CHNQD-00603-treated BMSCs.Conclusion: Our data suggested that CHNQD-00603 promoted the osteogenic differentiation of BMSCs by enhancing autophagy. Meanwhile, miR-452-3p played a regulatory role in this process.
The Association Between Dietary Inflammatory Index and Sex Hormones Among Postmenopausal Women in the US
Authors: Chen Wen-Yu , Fu Yan-Peng , Zhong Wen , Zhou Min 
Published: December 2021

AimsDiet has been found to have an important effect on sex hormones. The effect of diet-induced inflammation on sex hormones has not been studied in detail among women. Therefore, we aimed to investigate the association between energy-adjusted dietary inflammatory index (E-DII) and sex hormones among postmenopausal women.MethodsThis study used data from the National Health and Nutrition Examination Survey (NHANES) 2013–2016 waves. A total of 1183 postmenopausal women who provided information on two 24-hour dietary intake recalls, sex hormones including total testosterone (TT), estradiol (E2), TT/E2, sex hormone-binding globulin (SHBG), free estradiol (FE2) and free testosterone (FT), as well as selected covariates were included. Linear regression and restricted cubic spline evaluated the association between E-DII and sex hormones. Effect modification by body mass index (BMI) and type of menopause was then examined in stratified analysis.ResultsAfter adjusting for covariates, linear regression showed that E-DII was positively associated with TT (P=0.035), FT (P=0.026) and TT/E2 (P=0.065). TT (P-nonlinear = 0.037) and TT/E2 (P-nonlinear = 0.035) had significant nonlinear association with E-DII. E2 (P-nonlinear = 0.046) and FE2 (P-nonlinear = 0.027) depicted a nonlinear U-shaped significant association with E-DII, the two inflection points were found at the E-DII score of -0.22 and 0.07, respectively, the associations in natural menopausal women were more pronounced.ConclusionsOur study indicates that several indicators of androgen and estrogen were associated with E-DII in postmenopausal women. Further research is needed to understand the underlying mechanisms.
Screening and Functional Analysis of TPO Gene Mutations in a Cohort of Chinese Patients With Congenital Hypothyroidism
Authors: Wang Huijjuan , Wang Wenxia , Chen Xi , Shi Hailong , Shi Yinmin , Ding Guifeng 
Published: December 2021

BackgroundsAs a crucial enzyme in thyroid hormone synthesis, the genetic defective thyroid peroxidase (TPO) was one of the main genetic factors leading to congenital hypothyroidism (CH).MethodsMutations in the TPO gene were screened and identified in 219 patients with CH from northwest China by using high-throughput sequencing and bioinformatics analysis. The biological function of detected variants was studied by in vitro experiments and homology modeling.ResultsNineteen rare variants, including seven novel ones, were detected in 17 of 219 patients (7.8%). Most cases were detected with one single heterozygous variant, and only two patients were detected with multiple variants, i.e., compounds for (1) IVS7-1G&gt;A, p.Ala443Val, and p.Arg769Trp and (2) p.Asn592Ser and p.Asn798Lys. The biological function of the four missense mutations (i.e., p.Ala443Val, p.Arg769Trp, p.Asn592Ser, and p.Asn798Lys) they carried were further studied. Experimental data showed that these four mutations did not affect the protein expression level of the TPO gene but remarkably reduced the peroxidase activity toward guaiacol oxidation, retaining 8–32% of activity of the wild-type protein. The comparison of the predicted 3-D structures of wild-type and mutant TPO proteins showed that these four amino acid substitutions changed the non-covalent interactions of studied residues that might alter the structure and function of the TPO protein.ConclusionThis study was the first to analyze the TPO mutation spectrum of patients with CH in northwest China. Our data indicated that the TPO mutation was not a common reason to cause CH in China. The functional data may help to clarify the structure-function relationship of the TPO protein and provide further evidence for the elucidation of the genetic etiology of CH.
Effects of a Very Low-Carbohydrate High-Fat Diet and High-Intensity Interval Training on Visceral Fat Deposition and Cardiorespiratory Fitness in Overfat Individuals: A Randomized Controlled Clinical Trial
Authors: Cipryan Lukas , Dostal Tomas , Litschmannova Martina , Hofmann Peter , Maffetone Philip B. , Laursen Paul B. 
Published: December 2021

Purpose: This randomized controlled parallel-group study examined the effects of a very low-carbohydrate high-fat (VLCHF) diet and high-intensity interval training (HIIT) program over 12 weeks on visceral adipose tissue (VAT) and cardiorespiratory fitness (CRF) level in overfat individuals.Methods: Ninety-one participants were randomly allocated to the HIIT (N = 22), VLCHF (N = 25), VLCHF+HIIT (N = 25), or control (N = 19) groups for 12 weeks. Body composition and CRF were analyzed before the experimental period and after 4, 8, and 12 weeks. Dual-energy X-ray absorptiometry (DXA) and graded exercise test (GXT) to volitional exhaustion were used for the body composition and CRF assessments, respectively.Results: There were significant between-group differences in the VAT mass and body composition outcome changes. VAT mass decreased after 12 weeks only in the VLCHF and VLCHF+HIIT groups (p &lt; 0.001, median [95% CI]: VLCHF: −142.0 [−187.0; −109.5] g; VLCHF+HIIT: −104.0 [−135.0; −71.0] g). Similarly, changes in body mass, total body fat, trunk fat mass, waist and hip circumferences were distinctly decreased in the VLCHF and VLCHF+HIIT groups, when compared to HIIT and Control groups. Total lean mass significantly decreased in the VLCHF and VLCHF+HIIT groups (−2.1 [−3.0; −1.6] kg and −2.5 [−3.6; −1.8] kg, respectively) after 12 weeks. While the HIIT program significantly increased total time to exhaustion in the GXT, peak oxygen uptake was unchanged.Conclusions: A VLCHF diet, either in isolation or in combination with HIIT, was shown to induce a significant reduction in VAT mass and body composition variables. HIIT alone did not cause such effects on body composition, but improved exercise capacity. Our findings indicate that the VLCHF diet and exercise training provoked different and isolated effects on body composition and CRF.Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT03934476, identifier: NCT03934476.
Impaired Antioxidant Defence Status Is Associated With Metabolic-Inflammatory Risk Factors in Preterm Children With Extrauterine Growth Restriction: The BIORICA Cohort Study
Authors: Ordóñez-Díaz María Dolores , Gil-Campos Mercedes , Flores-Rojas Katherine , Muñoz-Villanueva María Carmen , Mesa María Dolores , de la Torre-Aguilar María José , Gil Ángel , Pérez-Navero Juan Luis 
Published: December 2021

Introduction: An impaired antioxidant status has been described during foetal growth restriction (FGR). Similarly, the antioxidant defence system can be compromised in preterm children with extrauterine growth restriction (EUGR). The aim of this prospective study was to evaluate the antioxidant status in prepubertal children with a history of prematurity without FGR, with and without EUGR, compared to a healthy group.Methods: In total, 211 children were recruited and classified into three groups: 38 with a history of prematurity and EUGR; 50 with a history of prematurity and adequate extrauterine growth (AEUG); and 123 control children born at term. Catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities were assessed in lysed erythrocytes with spectrophotometric methods. Plasma levels of the antioxidants α-tocopherol, retinol and β-carotene were determined through solvent extraction and ultra-high-pressure liquid chromatography coupled to mass spectrometry.Results: Children with the antecedent of EUGR and prematurity had lower CAT activity than the other two groups and lower GPx activity than the control children. Lower SOD, GPx and GR activities were observed in the AEUG group compared to the controls. However, higher concentrations of α-tocopherol and β-carotene were found in the EUGR group compared to the other groups; retinol levels were also higher in EUGR than in AEUG children. In EUGR and AEUG children, enzymatic antioxidant activities and plasma antioxidants were associated with metabolic syndrome components and pro-inflammatory biomarkers.Conclusions: This study reveals, for the first time, that the EUGR condition and prematurity appear to be linked to an impairment of the antioxidant defence status, which might condition an increased risk of adverse metabolic outcomes later in life.
MCM2-7 in Clear Cell Renal Cell Carcinoma: MCM7 Promotes Tumor Cell Proliferation
Authors: Zhang Junneng , Zhang Huanzong , Wang Yinghui , Wang Qingshui 
Published: December 2021

BackgroundClear cell renal cell carcinoma (ccRCC) accounts for 60-70% of renal cell carcinoma (RCC) cases. Finding more therapeutic targets for advanced ccRCC is an urgent mission. The minichromosome maintenance proteins 2-7 (MCM2-7) protein forms a stable heterohexamer and plays an important role in DNA replication in eukaryotic cells. In the study, we provide a comprehensive study of MCM2-7 genes expression and their potential roles in ccRCC.MethodsThe expression and prognosis of the MCM2-7 genes in ccRCC were analyzed using data from TCGA, GEO and ArrayExpress. MCM2-7 related genes were identified by weighted co-expression network analysis (WGCNA) and Metascape. CancerSEA and GSEA were used to analyze the function of MCM2–7 genes in ccRCC. The gene effect scores (CERES) of MCM2-7, which reflects carcinogenic or tumor suppressor, were obtained from DepMap. We used clinical and expression data of MCM2-7 from the TCGA dataset and the LASSO Cox regression analysis to develop a risk score to predict survival of patients with ccRCC. The correlations between risk score and other clinical indicators such as gender, age and stage were also analyzed. Further validation of this risk score was engaged in another cohort, E-MTAB-1980 from the ArrayExpress dataset.ResultsThe mRNA and protein expression of MCM2-7 were increased in ccRCC compared with normal tissues. High MCM2, MCM4, MCM6 and MCM7 expression were associated with a poor prognosis of ccRCC patients. Functional enrichment analysis revealed that MCM2-7 might influence the progress of ccRCC by regulating the cell cycle. Knockdown of MCM7 can inhibit the proliferation of ccRCC cells. A two-gene risk score including MCM4 and MCM6 can predict overall survival (OS) of ccRCC patients. The risk score was successfully verified by further using Arrayexpress cohort.ConclusionWe analyze MCM2-7 mRNA and protein levels in ccRCC. MCM7 is determined to promote tumor proliferation. Meanwhile, our study has determined a risk score model composed of MCM2-7 can predict the prognosis of ccRCC patients, which may help future treatment strategies.