bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Conceptual study on effect of Krauncha Beeja (Mucuna pruriens) Churna on serum prolactin levels and sperm count vis a vis Bromocriptine.
Authors: Dr. Mangesh Patil  
Published: April 2021

Hyperprolactinemia is detected in patients with infertility, impotence and hypogonadism. It is caused by or is associated with variety of pathological conditions such as pituitary adenoma, hypothalamic disorders, hypothyroidism, adrenocortical tumour etc. If hyperprolactinemia is the reason of Oligozoospermia then bromocriptine administration will improve sperm count.[5]
Kraunch beeja has been described to be useful in various diseases of reproductive system in books of Indian medicines (Ayurveda). Clinical research proves its effect on reduction of hyperprolactinemia. As it works on prolactin levels it can be used to treat both Oligozoospermia and Galactorrhoea.
The purpose of this study is to overview the effect of Krauncha beeja churna on Sr. Prolactin levels and Sperm count, like the effect of Bromocriptine. So that we can propose the use Krauncha beeja churna instead of Bromocriptine to control hyperprolactinemia and enhance sperm count.
“Role of Laja Manda in the management of Atisara (diarrhea) from Ayurvedic and modern perspective.”
Authors: Shete-Mapari Poonam 
Published: April 2021

Ayurveda is a holistic life science. It emphasizes more on preventive aspect than curative aspect of the disease. Hence, more importance has been given to appropriate ahara (dietary regimen), vihara (lifestyle regimen) than ausadhi dravya. Ahara is the main pillar of a body so called as mahabhaisajya. The ahara and vihara which are beneficial, nutritious and gives happiness to the mind is known as ‘Pathya’ and the opposite is called as ‘Apathya’. Pathya not only advocates intake of wholesome food but it also directs to follow a certain regimen to fasten the process of recovery from the diseased state. ‘Pathya Kalpana’ is one of the unique concepts in Ayurveda in which food recipes are used as medicines. It helps to maintain proper agni (digestive fire) so as to digest food properly and give needed nutrition to tissues of body. Such recipes are prepared by using aushadhi dravyas and food as base. Since pathya kalpana is the combination of medicines as well as food, it is not only useful in treating the disease but it also becomes palatable and pleasing. Laja Manda (scum of parched paddy) is one of the famous and routinely used pathya kalpana in diseases like atisara (diarrhea), chhardi (vomiting), jvara (fever). The purpose of present study is to understand the role of laja manda in the management of atisara (diarrhea) from both ayurvedic and modern perspective.
“Annam Vruttikaranam Shreshtham: Importance of diet in Brihattrayi.”
Authors: Bhagat Kavita 
Published: April 2021

The diet is one of the most important entity for Vrutti (Sustenance of life). The major treatises of Ayurveda (Brihattrayi), namely Charak Samhita, Sushruta Samhita and Ashtanga Hridaya (sometimes, Ashtanga Sangraha also) give logical and didactic explanation for it. The present review was aimed at compiling available information about importance of Ahara (diet) from these four treatises. The review can be helpful for understanding various concepts related to food in Ayurveda and can be implied in future studies.
The Charaka Samhita with Ayurveda Dipika commentary by Chakrapani, The Sushruta Samhita with Nibandha Sangraha commentary by Dalhana, The Ashtanga Hridaya with Sarvanga Sundara commentary by Arunadattta and Ashtanga Sangraha with Shashilekha commentary by Indu, were mainly reviewed for the present study. Supporting materials from ancient and contemporary sources were also reviewed. The classification of Ahara (diet) as well as Ahara Vidhi Vidhana (dietetic rules) have been reviewed from all four major treatises of Ayurveda. The aim of Ahara (diet) has been described in an all-inclusive approach converging to most important i.e. Vrutti (sustenance of life). This ultimate approach can be utilized in development of various diet plans for healthy as well as diseased people. As Ahara (diet) is the root cause and treatment of almost all diseases, this knowledge can prove to be useful for successful management of various conditions.
Evaluation of Swedopag Mahakashaya of Charak Samhita: A Literary Review
Authors: Pal Sandhya 
Published: April 2021

Acharya charak has mentioned Swedopag mahakashaya (adjuvants in sudation therapy) denotes ten medicines which act on swedan karma. swedopag can be correlate with formentation of modern medicine. Swedopag Mahakashaya is the 22nd gana of the 50 mahakashaya gana described in fourth chapter of Sutra sthan of Charak Samhita and includes shobhanjan, eranda, arka, vrushira(shwet punarnava), rakta punarnava,yava, til, kullatha, masha, badar ten ingredients. These 10 plants are work together and give enhanced effect. They are also effective individually. These plants having Katu, Tikta, Kasaya Rasa, Ushna(hotness) Virya, Katu Vipaka, tikshnam, saram(ability to spread) Guna and sukshma(minute) properties.
Role of Tridosha Siddhanta in the management of Kampavata w.s.r.t Parkinsonism
Authors: Dr. Ansari Huma  , Dr. Pravin Patil  
Published: April 2021

Ayurveda holistic science is based on entities like dosha, dhatu, and mala. Tridosha (i.e.vata, pitta, kapha) maintains health in an equilibrium state, and imbalance in these dosha develops diseased conditions in individuals. Vata is the only dosha that presides over all the other entities. In the present era, vatavyadhi is the most prevalent disease due to stress, improper sleep, improper diet and lifestyle, and old age. In Ayurveda, various nanatmaja vyadhi of vata has been explained, kampavata vyadhi is one of them. By comparing kampavata vyadhi with modern science most of the clinical features of this disease resemble Parkinson's disorder. Parkinson's disease is a group of progressive neurodegenerative disorders characterized by rest tremor, bradykinesia, muscular rigidity, shuffling gait, and flexed posture.
Hence, the endeavor is made to understand the concept of Tridosha Siddhanta in kampavata vyadhi and turn in the perspective of Parkinson's disease with the Ayurvedic approach.
Conceptual review of Amlapitta (Ayurvedic View)
Authors: Sawant Pravin Shamrao 
Published: April 2021

Amlapitta (Hyperacidity) is very common disease encountering in present population with more or less severity.Generally 80% of the top ten life threatening disease in the world are due to wrong in dietary habits.1 Amlapitta (Hyperacidity) is one of the commonest Vyadhi (Disease) of Annavaha strotas (Channel for digestion, absorbtion and transportation), caused by vitiated Agni (Digestive fire). Amlapitta (Hyperacidity) is a condition where Amlaguna (Sour taste) of Pachak Pitta increases due to Samata (toxins). Aacharya Charaka has not mentioned Amlapitta (Hyperacidity) as separate disease but described in Grahani (digestive disorder) as one of its lakshana.2According to Ayurveda, many disorders are due to vitiated Agni (digestive disorder).Various factors and progressive changes such as adaptation of newer and newer food materials, junk foods, fast foods, changes in method of cooking, occupational hazards etc. have precipitated the increasing trend of the disease. Along with those stimulating factors tremendous stress, anxiety had significantly aggravated the digestive disorders including Amlapitta (Hyperacidity). Here in this present study, Amlapitta disease is reviewed in detail according to ayurvedic view.
Pathya Apathya and role of Dinacharya in Nethra Swasthya
Authors: Chougule Nutan 
Published: April 2021

As Ayurveda gives much importance in maintaining health and prevention of diseases along with treatments of diseases. These Dinacharyas can be adopted in our day to day lives to protect the eye from diseases and improve the vision, by implementing improvised tailor-made techniques for day to day activities of present era. The Acharyas have armed us with proper knowledge to prevent and treat life style disorders related to eye diseases through explanation of Pathya Apathya and Dinacharyas which are practices of Kriyakalpas. Most of these practices are not being followed these days which leads to many Nethra Rogas. This can be corrected by re- implementing improvised versions of such practices in our daily life.
The wordChakshumeans which illuminates the objects and enlightens the mind about its details. which is situated in two eyeballs. When we talk about Pathya and Apathya, the importance of the word Chakshushya is came upon. . The Pathyas have been explained by different authors in the heading of Chakshushya Vargas and the Apathyas have been explained asAchakshushya.
TRADUÇÃO E ADAPTAÇÃO DO COGNITIVE RESERVE INDEX QUESTIONNAIRE (CRIq)
Authors: Ribeiro Teixeira Adriane , Domingos dos Santos Nicole , Dann Gamarra Mariana , Desgualdo Pereira Liliane 
Published: April 2021

Introdução: A Reserva Cognitiva (RC) é a capacidade cerebral construída ao longo da vida e que pode minimizar os danos clínicos advindos de um processo degenerativo, tais como as demências. Apresenta relação com a neuroplasticidade cerebral e pode ser avaliada por meio de questionários. Um destes é o Cognitive Reserve Index questionnaire (CRIq). Objetivo: relatar o processo de tradução e adaptação cultural do CRIq. Métodos: o questionário, originalmente em italiano, foi traduzido para o português por dois tradutores independentes. A partir destas duas traduções foi elaborada uma versão em português. Esta versão foi retrotraduzida para o italiano, por outros dois tradutores e comparada ao instrumento original. A versão em português foi aplicada a 30 indivíduos, sendo solicitado que apontassem sugestões. Na sequência, o CRIq em português foi apreciado por especialistas, para que apontassem modificações. Resultados: Foram mantidos o mesmo número de questões do original, para a avaliação de atividades relativas a escolaridade, trabalho e tempo livre. Os indivíduos que responderam ao instrumento inicial eram de ambos os sexos, tinham de 19 a 73 anos (média 39,13±12,97 anos) com níveis sócio-econômicos e de escolaridade variados. Eles não sugeriam modificações. Houve correlação entre a RC e a escolaridade (p=0,00). Os especialistas sugeriram termos para serem usados na seção tempo livre, devido às diferenças nas atividades de lazer na Itália e no Brasil. Conclusão: Foi concluída a tradução e adaptação semântica e de conteúdo do CRIq, sendo que o estudo inicial confirmou a rápida e prática aplicação do mesmo.
Pneumoretinopexy In Unusual Situations : Our Experience
Authors: Nagaraj Kalpana Badami , Devegowda Shilpa Y , Tumbadi Kavitha L , Govindaraj Bhavna , Bhandary Ridhi , Nataraj Spurti , Sushekar Vishrutha 
Published: April 2021

Aim:
To report the anatomical and visual outcome in patients who underwent pneumoretinopexy (PnR) as a primary procedure in unusual situations.

Material Method:
A prospective interventional analysis of 5 patients who underwent PnR as the primary treatment for rhegmatogenous retinal detachment (RRD), where either scleral buckling / vitrectomy was advised. Of the 5 patients with RRD, 1st had left eye subtotal RRD with superotemporal break of more than 1 clock hour size with grade A PVR changes, 2nd had left eye subtotal RRD with superonasal break with grade A PVR changes with torticollis, 3rd had left eye near total RRD with superotemporal break with grade A PVR changes, 4th was one-eyed with right eye total RRD with superior break with grade C PVR changes, and 5th had right eye temporal RRD with 2 retinal breaks which were more than 2 clock hours apart with grade A PVR changes. Trial of PnR with appropriate head positioning was done in all patients. Patients were followed up on postoperative day 1,1 week, 1 month and 6 months. Anatomical and visual outcomes were assessed.

Results:
All patients had good anatomical and visual outcomes.

Conclusion:
PnR can be considered as a primary treatment option in some simple RRDs with early PVR changes, even though they are not the ideal indications. It can also be useful in the management of RRDs, where there is a limitation for scleral buckling / vitrectomy.
Post-Operative Outcomes Of Intraocular Lens Implantation With Both Anterior And Posterior Optic Capture In Paediatric Cataract With Insufficient Lens Capsular Support
Authors: Shah Kalpit , Shah Smit 
Published: April 2021

Objective:
To assess the post-operative outcomes of intraocular lens implantation with both anterior and posterior optic capture in terms of visual axis opacification, ocular hypertension, centration of intraocular lens and iris and angle structure irritation in paediatric cataracts with either primary posterior capsular defect or traumatic rupture of anterior capsule or fibrotic anterior capsule or extended anterior capsulorrhexis.

Methods:
Sixteen (16) eyes of eleven (11) cases of paediatric cataract (5 bilateral and 6 unilateral) of 1 to 4 year of age with either insufficient posterior capsular support or traumatic rupture of anterior capsule or improper anterior capsule to perform anterior continuous curvilinear capsulorrhexis received both anterior and posterior optic capture of posterior chamber intraocular lens (3 piece). Visual axis opacification, intraocular lens centration and intraocular pressure were recorded. The follow up period was 6 to 18 months.

Results:
Implantation of intraocular lens (3 piece) with both anterior and posterior optic capture was performed successfully in sixteen eyes of paediatric cataract of 1 to 4 year of age. All the eyes had a clear visual axis with no visual axis opacification and maintained clinical centration of intraocular lens with normal intraocular pressure.

Conclusion:
Anterior and posterior optic capture of intraocular lens is a safe and effective method of treatment of paediatric cataract of 1 to 4 year of age with insufficient lens capsular support in prevention of visual axis opacification.
A Cross Sectional Study To Assess Knowledge Of Primary Open Angle Glaucoma Among Medical Students
Authors: Kaur Gagandeep , Supritha C N , Gupta NR , Goyal Sumit 
Published: April 2021

Objective:
To assess the knowledge of primary open-angle glaucoma among medical students from tertiary health centre, Punjab.

Methods:
In this cross sectional study, we conducted a survey among medical students. The questionnaire had 11 questions about epidemiology, risk factors, symptoms, diagnosis, treatment and sequelae of primary open angle glaucoma (POAG). The students were also asked if they considered their knowledge about POAG sufficient. Student's characteristics (age, sex and intended area of specialization) were identified.

Results:
Women comprised 60% of the students. 45% of students gave the correct answer that glaucoma is the leading cause of irreversible blindness worldwide. 48% of students identified POAG as having a genetic origin. Only 30% of students knew that POAG is asymptomatic and half of them (48%) knew that glaucoma blindness is irreversible. Many students (79%) correctly identified tonometry as an important tool for diagnosis and the glaucoma can be treated through medications (73%) or surgery (83%). Almost half of them (47%) considered their knowledge is insufficient.

Conclusion:
Almost half of the participants believe that their knowledge of POAG is insufficient. The results of this study showed that the basic knowledge of POAG among medical students is less. This gap can lead to some serious consequences from both individual (blindness) and collective (negative impact in health system and society) perspectives.
A Case of Idiopathic Orbital Inflammation And Third Nerve Palsy: Interesting Case
Authors: Tuli Rajeev , Dhiman Indu 
Published: April 2021

Purpose:
This case is a unique presentation of idiopathic orbital inflammation and 3rd nerve palsy (superior division involvement).

Case report:
A 30 years female patient presented with chief complaints of diplopia for two days and drooping of right upper eyelid for one day. Patient also complained of ocular pain and headache for preceeding ten days. Considering the clinical presentation, a differential diagnosis of thyroid orbitopathy, ocular myasthenia, orbital neoplasm and idiopathic orbital inflammatory syndrome (IOIS) was considered. Laboratory investigations revealed nothing significant. MRI orbit was suggestive of IOIS. The patient was started on oral steroids and had a favorable outcome.

Conclusion:
Understanding of the clinical features of patients with IOIS, differentiating it from other clinical conditions and timely implementation of available treatment may help to prevent visual loss and other associated morbidity from this condition.
Yield Gap Analysis in Major Field Crops of Tamil Nadu
Authors: Divakaran A. , Keerthana V. , Udhayakumar M. 
Published: April 2021

Agriculture plays a vital role in Indian economy, contributes 13% of gross domestic product and provides employment opportunities to more than 50% of work force. In India 60% of land area are arable leads to second largest country in terms of total arable land area. The technology development rate is 2 percent and farm productivity rate only increase by 0.3 percent in major crops. It implied that outreach of technology from lab to land have several constraints. In this study, yields gaps of major field crops are calculated with the data provided by the joint directorate of Tamil Nadu, to find, to which extent the advancement in agriculture is helpful and it is found out that the yield gap II of selected varieties of major crops are high. It shows the deviation from the potential yield of the variety with the actual yield obtained by the farmer.
Plants Used in Gynecology by the Malinke of South-eastern Senegal (Kédougou region)
Authors: Mathieu Gueye , Seydina Diop , Bernard Mingou Paterne Arnaud , Ibra Samb Papa 
Published: April 2021

Background: The collection and promotion of traditional knowledge is an international issue today. Thus, in this study we were interested in the local knowledge held by the Malinke of south-eastern Senegal on the plants used in gynecology. Methodology: The open semi-structured interviews technique, immersion, direct observations were used to collect local knowledge. The data are processed by descriptive statistical techniques for calculating ethnobotanical indices.
Results: The Malinke use 30 plants, belonging to 24 genera, distributed in 15 families, the most representative of which are the Fabaceae with 5 species, the Rubiaceae comprising 4 species, the Apocynaceae, the Combretaceae and the Moraceae with 3 species each. Their traditional mode of use compared to the practice of modern medicine allows the plants used to be classified into 7
Groups: oxytocics, antispasmodics, uterine antispasmodics, antiemetics, diuretics, muscle relaxants and galactogens. The most used species are Erythrina senegalensis, Ficus umbellata, Raphionacme splendens and Indigofera leptoclada. Bark is mostly used (38%), followed by the leaves and roots (22% each), while the most common method of preparation is a decoction (60%).
Conclusion: The study shows the importance of traditional medicine in rural areas of Kédougou region, south-eastern Senegal in the management of pregnancy, breastfeeding and maternal health. This is why a pharmacological characterization is underway to promote this local knowledge.
Method to Develop and Stress Degradation Profile of N-(2,6-dimethylphenyl)-2-{[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}Acetamide Studied by UV Spectroscopy
Authors: Afridi Muhammad Shaharyar Khan , Latif Abida , Fahham Hafiz Hanzalah , Rubab Kaneez , Aslam Itzaz , Ishtiaq Saiqa 
Published: April 2021

Background: Synthetic chemistry has always served as a back bone to the medicinal and pharmaceutical chemistry in terms of drug development and drug optimization. It helped in a great deal in finding new lead compounds and synthesizing new drugs. A new molecule N-(2,6-Dimethylphenyl)-2-{[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl] sulfanyl} acetamide, was synthesized from the fusion of Indole acetic acid with 1,3,4-oxadiazole. This pharmacologically active entity lacks a suitable method for its analysis.
Aim: The present research aimed to develop a UV visible spectroscopic method for the purpose followed by its validation according to ICH guidelines.
Methodology: The method was developed at 225 nm (λmax). Then the accuracy, precision, sensitivity (Limit of detection & Limit of quantification), specificity, robustness and ruggedness were calculated. The analyte was exposed to multiple stress conditions to figure out method’s specificity. Results: The developed method showed the linearity within a range (0.5 – 50 µg/mL) with correlation coefficient (R2) = 0.9997. The accuracy of the developed method was figured out by recovery analysis and it was within 95.556 – 104.321 %. The precision analysis i.e. interday (0.505591 %), intraday (0.231661 %) and repeatability (0.06478 %), were within the acceptance criteria viz. % RSD less than 2 % and LOD & LOQ were found to be 0.523356 and 1.58598 µg/mL. All the validation parameters were within the acceptance limits making the method unique and acceptable. In addition to that it was found to be easy, reliable and analyst friendly (ruggedness, 0.520889 %). The analyte when exposed to stress conditions viz. acidic (0.1N H2SO4) and basic (0.1N NaOH) environment, oxidative stress (3 % H2O2), UV light and altered temperature and humidity (80 ºC+75% RH) for 24 hr, it was found deteriorated. The analyte was 65.56 % degraded in acidic, 39.63 % in basic, 45.18 % under oxidative stress and 61.85 % under altered conditions of temperature and humidity. There was a complete loss of analyte (87.78 %) when exposed to UV light.
Conclusion: The results clearly states that the method is simple, sensitive, specific, precise and accurate, thus can be employed for the quantitative estimations of the analyte.
Clinical Presentation of Mandibular Impacted Teeth and Associated Pathologies in the Unaizah, Al Qaseem; Saudi Arabia
Authors: Shora Khaled Ramzi , Channar Kashif Ali , Shaikh Irfan Ahmed , Memon Abdul Bari , Shaikh Abdul Hayee , Maheshwari Bhavesh , Pershad Ram , Memon Mahnoor 
Published: April 2021

Aim: The aim of this study was to evaluate the clinical presentation of mandibular impacted teeth and associated pathologies in Unaizah, Al Qaseem; Saudi Arabia.
Study Design: Descriptive cross sectional study.
Place and Duration of Study: Department of Oral and Maxillofacial Surgery (OMFS), King Saud Hospital Unaizah Saudi Arabia from March 2019 and December 2020.
Methodology: The record of patients attending dental section was reviewed from hospital record. Demographic data of patients were recorded through medical record Number by Medicapluse software. Orthopantamograms (OPGs) xrays were reviewed by maxillofacial surgeons on Dell LCD using software IMPEX 6.3.1.2794 enterprise unlimited Agfa. The variables like presence of impacted tooth, type of angulations, reason for extraction, caries on distal surface of 2nd molar tooth, and occlusal or mesial surface of 3rd molar were examined on OPGs. Data was analyzed using SPSS version-21.
Results: Males and females were 49% and 51% respectively. The most common type of impaction was vertical 45%, followed by horizontal 27% and mesio angular 22%. The impacted tooth on right side was observed as 51% and on left side as 49%. The relationship of gender with type of impaction was statistically insignificant (p value-0.157). The relationship was reasons and type of impaction was statistically insignificant (p value-0.317)
Conclusion: the both genders were almost equally affected. Vertical Impactions were more frequent and the pericoronitis was common reason for extraction of mandibular third molar. The relationship of gender and type of impaction was not significantly associated with type of impaction.