bluuebunny/crossref_metadata_2025_split huggingface dataset:
Final Overall Survival Analysis of the TOURMALINE-MM1 Phase III Trial of Ixazomib, Lenalidomide, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma
Authors: Richardson Paul G. , Kumar Shaji K. , Masszi Tamás , Grzasko Norbert , Bahlis Nizar J. , Hansson Markus , Pour Luděk , Sandhu Irwindeep , Ganly Peter , Baker Bartrum W. , Jackson Sharon R. , Stoppa Anne-Marie , Gimsing Peter , Garderet Laurent , Touzeau Cyrille , Buadi Francis K. , Laubach Jacob P. , Cavo Michele , Darif Mohamed , Labotka Richard , Berg Deborah , Moreau Philippe 
Published: June 2021

PURPOSE The double-blind, placebo-controlled, phase III TOURMALINE-MM1 study demonstrated a statistically significant improvement in progression-free survival with ixazomib-lenalidomide-dexamethasone (ixazomib-Rd) versus placebo-Rd in patients with relapsed or refractory multiple myeloma. We report the final analyses for overall survival (OS). PATIENTS AND METHODS Patients were randomly assigned to ixazomib-Rd (n = 360) or placebo-Rd (n = 362), stratified by number of prior therapies (1 v 2 or 3), previous proteasome inhibitor (PI) exposure (yes v no), and International Staging System disease stage (I or II v III). OS (intent-to-treat population) was a key secondary end point. RESULTS With a median follow-up of 85 months, median OS with ixazomib-Rd versus placebo-Rd was 53.6 versus 51.6 months (hazard ratio, 0.939; P = .495). Lower hazard ratios, indicating larger magnitude of OS benefit with ixazomib-Rd versus placebo-Rd, were seen in predefined subgroups: refractory to any (0.794) or last (0.742) treatment line; age > 65-75 years (0.757); International Staging System stage III (0.779); 2/3 prior therapies (0.845); high-risk cytogenetics (0.870); and high-risk cytogenetics and/or 1q21 amplification (0.862). Following ixazomib-Rd versus placebo-Rd, 71.7% versus 69.9% of patients received ≥ 1 anticancer therapy, of whom 24.7% versus 33.9% received daratumumab and 71.8% versus 76.9% received PIs (next-line therapy: 47.5% v 55.8%). Rates of new primary malignancies were similar with ixazomib-Rd (10.3%) and placebo-Rd (11.9%). There were no new or additional safety concerns. CONCLUSION Median OS values in both arms were the longest reported in phase III studies of Rd-based triplets in relapsed or refractory multiple myeloma at the time of this analysis; progression-free survival benefit with ixazomib-Rd versus placebo-Rd did not translate into a statistically significant OS benefit on intent-to-treat analysis. OS benefit was greater in subgroups with adverse prognostic factors. OS interpretation was confounded by imbalances in subsequent therapies received, especially PIs and daratumumab.
Reading Ambient Literature: Immersion, Distraction, and the Situated Reading Experience
Authors: Spencer Amy 
Published: June 2021

Abstract
This article considers the experience and process of reading works of ambient literature, a form of situated literary experience delivered by pervasive computing platforms, responding to the presence of a physically situated reader to deliver a story. This form of situated digital work does not need to be bound by a material form, such as a printed book. Without such a framing device, and its position embedded in the physical world, this narrative form has boundaries that are often in flux. It can shift and respond to the presence of the situated reader, and its beginning and ending can become blurred. This article addresses the specifics of this fluid literary form, open to distraction and unpredictability for the reader, and examines the potential of a reading experience informed by pervasive and ubiquitous computing practices. In doing so, it draws on Ulrich Schmidt's notions of distraction and immersion in relation to the position of the reader. In particular, it addresses the idea that attention can dissolve in two opposite directions, toward a lack of concentration or toward an absorbed trance, a time of focused concentration and immersion, and explores how in ambient literature these become literary devices that lead and shape the reader's experience.
Performing the Emperor: Sui Jingchen's “Han Gaozu Returns to His Home Village”
Authors: Myhre Karin 
Published: June 2021

AbstractReading Sui Jingchen's song suite “Gaozu Returns to His Home Village” against early sources, this article explores how Sui's work selects and inverts the elements that ground definitive historical accounts of rulership to refashion a familiar narrative in a theatrical mode. The sanqu's use of performance tropes expands the scope of criticism in this humorous piece past concerns about Yuan rulership, or even the imperial institution, to broader questions of representational instability and uncertainty. These shifts implicate readers in a social and political critique and engage issues often associated with early modern fiction and drama, including authenticity, imposture, and interpolations of author, character, player, reader, and audience.
A Dialectic between Genres and Extension of Poetic Functions: Zhang Kejiu's “Regulated Songs”
Authors: Lee Jaehyuk 
Published: June 2021

Abstract
Zhang Kejiu occupies an important position in the history of sanqu (colloquial song). Not only does the sheer volume of his sanqu songs account for one-fifth of the extant sanqu songs, but his significance also lies in the unique style of his songs. In particular, his sanqu songs hybridize traditional literary elements with the up-and-coming form of sanqu. This article examines how Zhang embodied the aesthetics of classical poetry in the format of sanqu through a detailed examination of meter, parallel lines, and rhyme. Also, to demonstrate that the synthetic style of Zhang's sanqu songs was not merely the result of combining literary and colloquial styles, this article aims to reconstruct Zhang's idea about poetic functions underlying his literary syncretism by exploring his literary activities in the cultural context at his time.
Effects of Acute Dance and Aerobic Exercise on Drug Craving and Food Reward in Women with Methamphetamine Dependence
Authors: ZHOU YU , FINLAYSON GRAHAM , LIU XUDONG , ZHOU QICHEN , LIU TIANZE , ZHOU CHENGLIN 
Published: June 2021

ABSTRACT

Introduction
Drug dependence causes an overestimation of drug-related stimuli and an underestimation of non–drug-related stimuli, such as food. The purpose of this study was to investigate the effects of acute moderate-intensity dance and aerobic exercise on drug craving, appetite, prefrontal neural activation to food cues, and food reward in women with methamphetamine MA dependence.

Methods
Thirty-nine women who met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition MA dependence criteria participated in the experiment and were randomly assigned to either a dance (n = 20) or exercise (n = 19) group. A moderate-intensity (65%–75% maximum heart rate) 35-min dance or treadmill intervention counterbalanced with a reading control session was conducted. After the intervention or control, subjective drug craving was measured before and after exposure to drug-related cues. Visual analog scales were used to measure subjective feelings of appetite. Participants then completed a visual food cue paradigm while using functional near-infrared spectroscopy to monitor prefrontal blood oxygen changes. Finally, the Leeds Food Preference Questionnaire was used to measure reward responses to different categories of food.

Results
The results showed that the dance and exercise interventions reduced subjective craving for drugs after being exposed to drug cues (P = 0.019). Implicit wanting (P < 0.001) and relative preferences (P = 0.001) for high-calorie savory foods were all increased after interventions relative to control. Compared with the control session, the left dorsolateral prefrontal cortex (P = 0.020) was activated when viewing high-calorie foods after moderate-intensity aerobic exercise.

Conclusions
The current results support the use of moderate-intensity exercise as a therapeutic intervention to restore the balance between drug and nondrug rewards by decreasing cue-induced MA craving and increasing food reward.
Quantitative diffusion and perfusion MRI in the evaluation of endometrial cancer: validation with histopathological parameters
Authors: Satta Serena , Dolciami Miriam , Celli Veronica , Di Stadio Francesca , Perniola Giorgia , Palaia Innocenza , Pernazza Angelina , Della Rocca Carlo , Rizzo Stefania , Catalano Carlo , Capuani Silvia , Manganaro Lucia 
Published: June 2021

Objectives:
To investigate the role of quantitative Magnetic Resonance Imaging (MRI) in preoperative assessment of tumour aggressiveness in patients with endometrial cancer, correlating multiple parameters obtained from diffusion and dynamic contrast-enhanced (DCE) MR sequences with conventional histopathological prognostic factors and inflammatory tumour infiltrate.

Methods:
Forty-four patients with biopsy-proven endometrial cancer underwent preoperative MR imaging at 3T scanner, including DCE imaging, diffusion-weighted imaging (DWI) and intravoxel incoherent motion imaging (IVIM). Images were analysed on dedicated post-processing workstations and quantitative parameters were extracted: Ktrans, Kep, Ve and AUC from the DCE; ADC from DWI; diffusion D, pseudo diffusion D*, perfusion fraction f from IVIM and tumour volume from DWI. The following histopathological data were obtained after surgery: histological type, grading (G), lympho-vascular invasion (LVI), lymph node status, FIGO stage and inflammatory infiltrate.

Results:
ADC was significantly higher in endometrioid histology, G1-G2 (low grade), and stage IA. Significantly higher D* were found in endometrioid subptype, negative lymph nodes and stage IA. The absence of LVI is associated with higher f values. Ktrans and Ve values were significantly higher in low grade. Higher D*, f and AUC occur with the presence of chronic inflammatory cells, D * was also able to distinguish chronic from mixed type of inflammation. Larger volume was significantly correlated with the presence of mixed-type inflammation, LVI, positive lymph nodes and stage ≥IB.

Conclusions:
Quantitative biomarkers obtained from pre-operative DWI, IVIM and DCE-MR examination are an in vivo representation of the physiological and microstructural characteristics of endometrial carcinoma allowing to obtain the fundamental parameters for stratification into Risk Classes.

Advances in knowledge:
Quantitative imaging biomarkers obtained from DWI, DCE and IVIM may improve preoperative prognostic stratification in patients with endometrial cancer leading to a more informed therapeutic choice.
A comparison of the fusion model of deep learning neural networks with human observation for lung nodule detection and classification
Authors: Gürsoy Çoruh Ayşegül , Yenigün Bülent , Uzun Çağlar , Kahya Yusuf , Büyükceran Emre Utkan , Elhan Atilla , Orhan Kaan , Kayı Cangır Ayten 
Published: June 2021

Objectives:
To compare the diagnostic performance of a newly developed artificial intelligence (AI) algorithm derived from the fusion of convolution neural networks (CNN) versus human observers in the estimation of malignancy risk in pulmonary nodules.

Methods:
The study population consists of 158 nodules from 158 patients. All nodules (81 benign and 77 malignant) were determined to be malignant or benign by a radiologist based on pathologic assessment and/or follow-up imaging. Two radiologists and an AI platform analyzed the nodules based on the Lung-RADS classification. The two observers also noted the size, location, and morphologic features of the nodules. An intraclass correlation coefficient was calculated for both observers and the AI; ROC curve analysis was performed to determine diagnostic performances.

Results:
Nodule size, presence of spiculation, and presence of fat were significantly different between the malignant and benign nodules (p &lt; 0.001, for all three). Eighteen (11.3%) nodules were not detected and analyzed by the AI. Observer 1, observer 2, and the AI had an AUC of 0.917 ± 0.023, 0.870 ± 0.033, and 0.790 ± 0.037 in the ROC analysis of malignity probability, respectively. The observers were in almost perfect agreement for localization, nodule size, and lung-RADS classification [κ (95% CI)=0.984 (0.961–1.000), 0.978 (0.970–0.984), and 0.924 (0.878–0.970), respectively].

Conclusion:
The performance of the fusion AI algorithm in estimating the risk of malignancy was slightly lower than the performance of the observers. Fusion AI algorithms might be applied in an assisting role, especially for inexperienced radiologists.

Advances in knowledge:
In this study, we proposed a fusion model using four state-of-art object detectors for lung nodule detection and discrimination. The use of fusion of deep learning neural networks might be used in a supportive role for radiologists when interpreting lung nodule discrimination.
Fracture resistance and 3D finite element analysis of machined ceramic crowns bonded to endodontically treated molars with two planes versus flat occlusal preparation designs: an in vitro study
Authors: Nabil Omnia , Halim Carl Hany , Mokhtar Ashraf Hassan 
Published: June 2021

Background: The flat occlusal preparation design (FOD) of posterior teeth offers promising results of fracture resistance and stress distribution, but its application in vital teeth is limited as there may be a danger of pulp injury. Although this danger is omitted in endodontically treated teeth, there is no research work assessing the impact of FOD on the fracture resistance and distribution of stresses among these teeth. The aim of this study was to assess the impact of FOD of endodontically treated molars on the fracture resistance and distribution of stresses among a ceramic crown-molar structure when compared to the two planes occlusal preparation design (TOD). Methods: 20 human mandibular molars were endodontically treated and distributed equally to two groups: Group I (TOD) and Group II (FOD). Ceramic CAD/CAM milled lithium disilicate (IPS e.max CAD) crowns were produced for all preparations and adhered using self-adhesive resin cement. Using a universal testing machine, the fracture resistance test was performed. The fractured samples were examined using a stereomicroscope and scanning electron microscope to determine modes of failure. Stress distribution was evaluated by 3D finite element analysis, which was performed on digital models of endodontically treated mandibular molars (one model for each design). Results: Group II recorded statistically non-significant higher fracture resistance mean values (3107.2± 604.9 N) than Group I mean values (2962.6 ±524.27 N) as indicated by Student’s t-test (t=0.55, p= 0.57). Also, Group II resulted in more favorable failure mode as compared to Group I. Both preparation designs yielded low von-Mises stresses within the factor of safety. However, the stress distribution among different layers of the model differed. Conclusions: FOD having comparable fracture strength to TOD and a more favorable fracture behavior can be used for the preparation of endodontically treated molars.
The Relief of Harput
Authors: Abay Eşref , Demir Bülent , Sevin Veli 
Published: June 2021

AbstractIn the spring of 2016 a unique stone slab carved in relief was accidentally discovered on Kurey Tepesi near Harput/Elazığ in eastern Turkey. The relief depicts the capture of a heavily fortified city in horizontally arranged registers. At first sight it comes to recognition that the Harput Relief stands in the tradition of Mesopotamian victory steles, starting with the Eannatum Stele (Stele of Vultures) in Early Dynastic Sumer (c. 2900–2350 BC) and continuing with the kings of Akkad (c. 2350–2150 BC). From a stylistic and iconographic point of view, the relief seems closer to the victory stele of Daduša of Ešnunna and the Mardin Stele of the early Old Babylonian period (c. 2000–1600 BC). The subsequently excavated archaeological context, a heavily burned architectural layer, contained Middle Bronze Age I pottery typical of the Elazığ-Malatya region, corroborating a date in the early second millennium BC.
Developing interpersonal and intercultural skills in a university language course
Authors: Bavieri Luisa , Beaven Ana 
Published: June 2021

Abstract
Intercultural language learning and teaching is generally endorsed in contemporary foreign and second language classroom contexts. This article reports the use of an intercultural education activity taught in an Italian L2 elementary course at the Language Centre of the University of Bologna attended by exchange and degree-seeking students. The intercultural tasks proposed invite students to reflect on their experiences of studying and living in a different country, and encourage them to reflect on their intercultural learning objectives and on their goals for study abroad in relation to their intercultural encounters. Our aim was to explore students’ willingness to engage with the intercultural tasks, their commitment and the possible influence on their behaviours, attitudes and beliefs, considering their relatively limited level of target language proficiency. The data, collected through audio-recorded interviews, show individual differences among the students. Our report concludes with our reflections as practitioners working in a university language centre, on the importance of intercultural language teaching and learning.
Naturalism, Wittgensteinian Grammar, and Initiation into Interreligious Exploration
Authors: Kiem Youngjin 
Published: June 2021

Abstract
This paper lays out the first step towards a complete methodology of interreligious investigation, emphasizing the issue of how we should treat individual religions while not committing ourselves to religious apologetics in general. From that perspective, I introduce two theoretical requirements that the methodology of interreligious exploration should fulfill, what we call the constraint of consistency and ontology and the constraint of absoluteness and plurality. The article expounds how and on what grounds those two methodological constraints can be fulfilled by the philosophical notions of “naturalism” and “religion as grammar.” In doing so we reach the following methodological canons: When initiating interreligious exploration, (1) adopt an “open-ended minimal naturalism” in which transcendent realities appearing in individual religions are neither affirmed nor denied in advance, and (2) on the basis of that naturalism, take individual religions as different systems of grammar, that is, distinct linguistic-conceptual frameworks upon which one can see and understand various religious worlds in a constitutive way. The paper is the exposition and defense of these ideas.
Evidenzbasierte Gebärumgebung: die Be-Up-Studie
Authors: Ayerle Gertrud M. , Mattern Elke , Oganowski Theresa , Schäfers Rainhild , Striebich Sabine 
Published: June 2021

ZusammenfassungDas 9. Nationale Gesundheitsziel „Gesundheit rund um die Geburt“ und evidenzbasierte Leitlinien fordern die Förderung der physiologischen Geburt. Das RCT „Be-Up: Geburt aktiv“ untersucht die Wirkung eines alternativ gestalteten Gebärraums auf die Rate vaginaler Klinikgeburten. Die Umsetzung des RCT und die Rekrutierung von 3.800 Studienteilnehmerinnen sind nur durch die Teilnahme der 17 Be-Up-Kliniken möglich. Die Ergebnisse werden für Klinikpersonal, Entscheidungsträger und die Hebammenwissenschaft von Interesse sein.
Peripartale Gesundheit asylsuchender Frauen in der Schweiz: who cares?
Authors: Wegelin Milena , Origlia Ikhilor Paola , Mühlheim Raquel , Perrenoud Grand-Guillaume Anthony , Cignacco Müller Eva 
Published: June 2021

ZusammenfassungDie sexuelle und reproduktive Gesundheit von asylsuchenden Frauen findet in der Gesundheitsversorgung wenig Aufmerksamkeit. Für diese vulnerable Population wurden in der Schweiz zentrale Zugangsbarrieren zur peripartalen Gesundheitsversorgung identifiziert, die mit schlechteren neonatalen und mütterlichen Outcomes einhergehen. Eine Studie der Berner Fachhochschule erhebt aktuell Daten zur Perspektive von asylsuchenden Frauen, um die Zugangsbarrieren aus deren Sicht besser zu verstehen.
A City of One’s Own: Heterotopias in Ivana Šojat’s Unterstadt
Authors: Novak Sonja 
Published: June 2021

Summary
The paper analyses the phenomenon of heterotopias as they are described by Michel Foucault and the way they are employed in literature and theatre. The paper argues that each time an author writes or re-writes, a director stages, a member of the audience sees and reader reads a fictional narrative that is set into a non-fictional place (e. g. a city), a heterotopia, “another”, different place is created by means of conceptual integration. This will be exemplified on the contemporary Croatian novel Unterstadt by Ivana Šojat and its stage adaptation.
Effects of Different Velocity Loss Thresholds on Passive Contractile Properties and Muscle Oxygenation in the Squat Exercise Using Free Weights
Authors: Muñoz-López Alejandro , Marín-Galindo Alberto , Corral-Pérez Juan , Costilla Manuel , Sánchez-Sixto Alberto , Sañudo Borja , Casals Cristina , Ponce-González Jesús G. 
Published: June 2021

Abstract
Muñoz-López, A, Marín-Galindo, A, Corral-Pérez, J, Costilla, M, Sánchez-Sixto, A, Sañudo, B, Casals, C, and Ponce-González, JG. Effects of different velocity loss thresholds on passive contractile properties and muscle oxygenation in the squat exercise using free weights. J Strength Cond Res 36(11): 3056–3064, 2022—The current study assessed the impact between different velocity loss thresholds on changes in the muscle contractile properties and muscle oxygenation after a single resistance training (RT) session. Thirty physically active men participated in a crossover study performing 3 sets of the squat exercise at a lifted speed of ≈0.75 m·s −1, with 2 different velocity loss thresholds: 20% (VL20) vs 40% (VL40) in a randomized order. Contractile properties of the knee extensor muscles were tested using tensiomyography. In addition, muscle oxygenation was continuously measured from baseline until the end of the exercise session. The vastus lateralis showed a significant moment by condition interaction in time delay (p = 0.044), muscle displacement (p = 0.001), and contraction velocity (p = 0.007), with greater reductions in VL40. In both trainings, oxygenated hemoglobin and tissue oxygen index decreased, whereas deoxygenated hemoglobin increased (moment as the main effect, p < 0.05), but without a moment by condition interaction. VL40 showed a lower deoxygenation slope in set 1 (−0.468%·s−1, p = 0.001) and set 3 (−0.474%·s−1, p = 0.037) as well as higher losses in set 1 (−41.50%, p = 0.003), set 2 (−41.84%, p = 0.002), and set 3 (−62.51%, p < 0.001), compared with VL20. No differences were found in the recovery period between conditions. In conclusion, during the RT program design, coaches and athletes should consider that VL40 produces higher mechanical and neuromuscular impairments than VL20, which seems to be necessary for hypertrophy to occur; however, VL40 also produces a longer period of lower oxygen supply than VL20, which can induce fast-to-slow muscle fiber transition.