bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA Malat1 regulates iPSC-derived β-cell differentiation by targeting the miR-15b-5p/Ihh axis
Authors: Wang Yao , Lin Xinxing , Lv Jin , Zhu Jiachen , Fan Haowen , Sha Jinqi , Xu Zhen , Zhu Biwen , Guo Qinsong , Wang Zhiwei , Zhu Shajun 
Published: January 2021

Abstract
Background: Differentiation of induced pluripotent stem cell (iPSC)-derived β-like cells is a novel strategy for treatment of type 1 diabetes. Elucidation of the regulatory mechanisms of long noncoding RNAs (lncRNAs) in β-like cells derived from iPSCs is important for understanding the development of the pancreas and pancreatic β-cells and may improve the quality of β-like cells for stem cell therapy.Methods: β-like cells were derived from iPSCs in a three-step protocol. RNA sequencing and bioinformatics analysis were carried out to screen the differentially expressed lncRNAs and identify the putative target genes separately. LncRNA Malat1 was chosen for further research. Series of loss and gain of functions experiments were performed to study the biological function of this lncRNA. Quantitative real-time PCR (qRT-PCR), Western blot analysis and immunofluorescence (IF) staining were carried out to separately detect the functions of pancreatic β-cells at the mRNA and protein levels. Cytoplasmic and nuclear RNA fractionation and fluorescence in situ hybridization (FISH) were used to determine the subcellar location of lncRNA Malat1 in β-like cells. Flow cytometry and enzyme-linked immunosorbent assays (ELISAs) were performed to examine the differentiation and insulin secretion of β-like cells after stimulation with different glucose concentrations. Structural interactions between lncRNA Malat1 and miR-15b-5p and between miR-15b-5p and Ihh were detected by dual luciferase reporter assays (LRAs).Results: We found that the expression of lncRNA Malat1 declined during differentiation, and overexpression of this lncRNA notably impaired the differentiation and maturation of β-like cells derived from iPSCs in vitro and in vivo. Localized to the cytoplasm, lncRNA Malat1 could function as a competing endogenous RNA (ceRNA) of miR-15b-5p to regulate the expression of Ihh according to bioinformatics prediction, mechanistic analysis and downstream experiments.Conclusion: This study established an unreported regulatory network of lncRNA Malat1 and the miR-15b-5p/Ihh axis during the differentiation of iPSCs into β-like cells. In addition to acting as an oncogene promoting tumorigenesis, lncRNA Malat1 may be an effective and novel target for treatment of diabetes in the future.
Covid-19 and Library Public Space Transformations
Authors: ANTONENKO Nadiia , RUMILETS Tetiana 
Published: January 2021

Abstract
The paper discusses the transformation of library spaces that occurred as a result of the spread of the SARS-CoV-2 coronavirus, as well as the directions of further spatial changes in library spaces under new pandemic conditions. The study is based on the integrated use of research methods. As part of the study, the functional-planning organization of library spaces was analyzed before and during the pandemic, and the content of the crisis of the social institution of libraries in the new conditions was formulated. The experience of transformations of other types of buildings – offices, restaurants, hospitals, etc. – was examined and the appropriateness of using these design techniques in library spaces was examined, individual planning techniques were highlighted as fundamental for further space-planning transformations, and considered as basic recommendations for adaptations, reconstruction and construction of new library buildings. Particular attention is paid to updating the focus on maintaining public health, including through the more active implementation of appropriate environmental standards in the construction.
Circular Economy in Wastewater Treatment Plant
Authors: KALEMBA Katarzyna 
Published: January 2021

Abstract
Wastewater treatment plants are becoming an important part of circular economy. In addition to the classic role of wastewater treatment plants, they are gaining a new important mission to fulfil. According to the Nutrients-Energy-Water (N-E-W) paradigm, wastewater treatment plants should also focus on energy production and resource recovery. Intensification of biogas production is an important element in improving the energy efficiency of wastewater treatment plants. This can be achieved by introducing sewage sludge co-digestion with organic substrate, thermal hydrolysis and disintegration of the sludge. Water renewal, which includes a number of processes to restore the water features of the wastewater, is also becoming an important objective. Intensive research is being carried out on the production of bioplastics by bacteria inhabiting municipal and industrial sewage. Technologies for recovery of nutrients (nitrogen and phosphorus) from sewage and sludge are also advanced. The paper presents current trends in the development of sewage treatment plants based on the assumptions of circular economy and current policy of the European Green Deal.
Modeling of Environmental-Energy Efficiency of the Biogas Installation with Heat Supplying of the Biomass Fermentation Process
Authors: RATUSHNIAK Georgiy , BIKS Yuriy , LYALYUK Olena , RATUSHNYAK Olga , LYALYUK Andriy 
Published: January 2021

Abstract
The determinants of profitability and environmental friendliness of bioconversion are noted in the paper. As one of the major factors the reduction of thermal energy costs for the fermentation of organic wastes in their utilization is proposed to take into consideration. The expediency of using renewable energy sources for thermal stabilization of the fermentation process, especially in the thermophilic mode of organic fermentation, is emphasized. The energy efficiency biogas installation with structural and technological scheme is given as an example. It receives thermal energy to increase its efficiency from a solar collector and a heat pump. It is proposed to evaluate the energy efficiency of a biogas plant taking into account the cost of bioconversion products and the costs of providing this process. A mathematical model was proposed to substantiate the environmental-economic efficiency of a biogas installation with the minimum energy costs for the thermal stabilization of the biomass fermentation process. The model is based on fuzzy set theory which uses linguistic variables. Linguistic variables take into account the influence of quantitative and qualitative factors on the objective function.
La alegría de ser nada
Authors: Garrido-Maturano Ángel Enrique 
Published: January 2021

El artículo analiza el discurso de S. Kierkegaard “Todo buen don y toda dádiva perfecta viene de arriba” y lo articula con otros dos Discursos edificantes. La articulación procura, primero, elucidar por qué el sí mismo auténtico es aquel que asume que no puede nada. Segundo, muestra silencio, obediencia y alegría como las actitudes fundamentales sobre cuya base el sí mismo auténtico es en el mundo y caracteriza la fe originaria implícita en ellas como su condición de posibilidad. Finalmente, explicita el mundo en el que es el sí mismo auténtico como sitio justo abierto a la espera del reino.
SOSIO EMOSIONAL DALAM MODEL PEMBELAJARAN BERBASIS MASALAH TERHADAP PRESTASI BELAJAR KIMIA DITINJAU DARI KOGNITIF SISWA MADRASAH ALIYAH
Authors: Hidayah Malikhatul 
Published: January 2021

Penelitian ini bertujuan untuk menganalisis perbedaan prestasi bela- jar kimia dengan kondisi sosio emosional yang mencipkatan suatu kondisi yang belajar yang baik,efektif serta efisien: (1) antara siswa yang mengikuti model pembelajaran berbasis masalah dan pembelajaran eksplorasi, elaborasi, konfirmasi (EEK), (2) terhadap pengaruh interaksi model pembelajaran dengan gaya kognitif, (3) antara siswa yang mengikuti model pembela- jaran berbasis masalah dan pembelajaran EEK pada siswa yang memiliki gaya kognitif field independent, dan (4) antara siswa yang mengikuti model pembelajaran berbasis masalah dan EEK pada siswa yang memiliki gaya kognitif field dependent. Penelitian ini merupakan kuasi eksperimen dengan rancangan faktorial 2x2 posttest only control group design. Subjek penelitian ini adalah siswa kelas X Madrasah Aliyah Walisongo Jepara tahun pela- jaran 2013/2014. Pengambilan kelas penelitian berdasarkan teknik intake kelas. Data yang diperoleh dianalisis dengan statistik deskriptif dan Anova dua jalur. Hasil penelitian menunjukkan (1) perbedaan signifikan terhadap variable prestasi belajar kimia dan kondisi sosio emosional siswa se- cara bersama-sama (F=2,944; p0,05). Artinya, prestasi belajar kimia dan kondisi sosio emosional siswa bersama-sama menunjukkan perbedaan signifikan antara model pembelajaran; (2) interaksi antara model pembela- jaran dan gaya kognitif secara bersama terhadap prestasi belajar kimia dan kondisi sosio emosional siswa (F=47,456; p0,05); (3) perbedaan signifikan variabel model pembelajaran terhadap prestasi belajar kimia dan kondisi sosio emosional siswa untuk siswa yang bergaya kognitif field independent (F=34,337; p0,05); (4) perbedaan signifikan variabel model pembelajaran terhadap prestasi belajar kimia dan kondisi sosio emosional siswa untuk siswa yang memiliki gaya kognitif field dependent (F=17,912; p0,05).
ANALISIS KETERAMPILAN DASAR MENGAJAR MAHASISWA CALON GURU KIMIA (STUDI PADA PRAKTIK PENGALAMAN LAPANGAN MAHASISWA TADRIS KIMIA)
Authors: S Mulyatun 
Published: January 2021

Pembekalan praktis kependidikan bagi mahasiswa calon guru di LPTK mutlak diperlukan untuk meningkatkan kompetensi calon guru ke- tika terjun di dunia pendidikan. Pembekalan ini dapat dilakukan melalui berbagai kegiatan, diantaranya melalui praktik pengajaran secara mikro (microteaching) maupun melalui praktik mengajar secara riil di sekolah (Praktik Pengalaman Lapangan). Penelitian ini bertujuan untuk menge- tahui tingkat penguasaan keterampilan dasar mengajar calon guru Tadris Kimia Fakultas Tarbiyah IAIN Walisongo pada kegiatan Praktik Pengala- man Lapangan (PPL).Penelitian dilaksanakan di Program Studi Tadris Kimia Fakultas Tar- biyah IAIN Walisongo Semarang dengan melibatkan mahasiswa Tadris Kimia yang mengambil mata kuliah Praktik Pengalaman Lapangan. Data diperoleh dengan metode observasi pada kegiatan pembelajaran di kelas oleh mahasiswa calon guru Kimia. Delapan keterampilan dasar mengajar mahasiswa diamati dan dianalisis pada pelaksanaan Praktik Pengalaman Lapangan meliputi (1) Keterampilan bertanya, (2) Keterampilan mem- beri penguatan, (3) Keterampilan mengadakan variasi, (4) Keterampilan menjelaskan, (5) Keterampilan membuka dan menutup pelajaran, (6) Ket- erampilan membimbing diskusi kelompok kecil, (7) Keterampilan menge- lola kelas, (8) Keterampilan mengajar kelompok kecil dan perorangan.Delapan keterampilan dasar mengajar Mahasiswa Tadris Kimia pada pelaksanaan PPL secara keseluruhan adalah baik dangan persentase pe- nilaian mencapai 69,59%. Keterampilan dasar mengajar mahasiswa Tad- ris Kimia yang paling menonjol adalah ketrampilan memberi penguatan (74,14%), sedangkan ketrampilan yang paling rendah adalah keterampilan mengadakan variasi (64,86%).
PENINGKATKAN KETUNTASAN DAN MOTIVASI BELAJAR FISIKA SISWA KELAS XB SEMESTER I SMA NEGERI I GUBUG MENGGUNAKAN MODUL PEMBELAJARAN PADA POKOK BAHASAN GERAK LURUS TAHUN PELAJARAN 2013 / 2014
Authors: Rahmadi Deny 
Published: January 2021

Dari data hasil belajar Fisika Pokok Bahasan Besaran dan Satuan nilai rata-rata siswa kelas XB SMA Negeri I Gubug tahun pelajaran 2013/2014 masih di bawah 6,0. Ini menunjukkan masih rendahnya ketuntasan belajar siswa kelas XB SMA Negeri I Gubug tahun pelajaran 2013/2014 Kabu- paten Grobogan tahun pelajaran 2013/2014 dimana KKM yang ditetapkan oleh Sekolah adalah 75. Proses pembelajaran dalam penelitian ini mengu- nakan modul pembelajaran fisika.Obyek penelitian ini adalah siswa kelas XB SMA Negeri I Gubug Kabupaten Grobogan tahun pelajaran 2013/2014. Data penelitian dianalisis secara teknik diskriptip. Dari analisis data penelitian menunjukkan bahwa motivasi belajar mengalami peningkatan dibanding sebelum menggunakan modul pembelajaran. Begitu juga un- tuk hasil belajar afektif, kognitif dan psikomotor mengalami peningkatan dalam tiap siklusnya.
PAHAM INGKAR SUNAH DI INDONESIA (STUDI TENTANG PEMIKIRANNYA)
Authors: Khon Abdul Majid 
Published: January 2021

Paham Ingkar Sunah Indonesia timbul dari ketidak tahuannya tentang status Sunah dalam beragama dan tentang fungsi Sunah terhadap al-Qur’an. Semangat belajar mereka hanya pada al-Qur’an. Tetapi sayangnya mereka sangat minim penguasaan ilmu-ilmu dasar untuk memahami al-Qur’an seperti bahasa Arab, tata bahasa dan sastranya, ilmu-ilmu Tafsir dan lain-lain. Mayoritas ide-ide penolakan Sunah ditransfer dari orientalis yang sengaja meng­hembuskan di dunia Islam untuk menyesatkan umat. Inti pandangan mereka bahwa dalam beragama hanyalah al-Qur’an karena kesem­pur­­naannya sedangkan Sunah atau hadis dipan­dang sebagai dongeng yang diciptakan oleh se­bagian umat Islam belakangan. Mengikuti Hadis mimicu perpecahan umat yang meneybabkan kelemahan dan kehancuran umat
MENYEMAI NASIONALISME DARI SPIRIT AGAMA: UPAYA MEREDAM RADIKALISME BERAGAMA
Authors: Amin Nasihun 
Published: January 2021

Indonesia adalah negara yang paling majemuk. Harus diakui bahwa pengelolaan terhadapnya merupakan pekerjaan yang tidak mudah. Apalagi meleburkan dalam sebuah pemahaman bahwa dalam kemajemukan tersebut ada kesatuan yang harus dipegang dan diperjuangkan bersama. Oleh kjarena itu, Sumpah Pemuda yang didengungkan pada 28 Oktober 1928 adalah prestasi luar biasa yang patut mendapatkan apresiasi. Demikian pula, kesanggupan para pendiri bangsa, terutama yang berbasis agama Islam, untuk dan demi nasionalisme kemudian mereka menundukkan egoisme karena adanya posisi mayoritasnya juga harus mendapatkan penghargaan. Hanya saja, belakangan ini, di beberapa kalangan semangat nasionalisme sedikit mulai melemah justru karena dipicu oleh semangat keagamaan. Mengingat kondisi demikian, maka perlu ditumbuhkan semangat nasionalisme berbasis spirit agama sehingga menjadi seorang pemeluk agama sejati adalah seorang nasionalis sejati
The Prevalence of Diabetes in Autistic Persons: A Systematic Review
Authors: Tromans Samuel , Yao Guiqing , Alexander Regi , Mukaetova-Ladinska Elizabeta , Kiani Reza , Al-Uzri Mohammed , Chester Verity , Carr Richard , Morgan Zoe , Vounzoulaki Elpida , Brugha Traolach 
Published: January 2021

Background:It has been proposed that autistic individuals are at an increased risk of type 1 and type 2 diabetes. Improved understanding of diabetes prevalence in autistic persons will help inform resource allocation for diabetes-related public health measures for this patient group.Objective:To conduct a systematic review of published literature pertaining to type 1 and type 2 diabetes prevalence in autistic individuals, including comparison with their non-autistic peers.Methods:Eligibility criteria included studies investigating the prevalence of diabetes in autistic individuals, as well as having been published in the English language. A systematic search of online databases (MEDLINE, PsycINFO, CINAHL, EMBASE and PubMed) was conducted on 4thApril 2020. Additional approaches included the ancestry method, grey literature searches and expert consultation. Studies were qualitatively analysed with reporting quality appraised.Results:19 eligible studies were identified, 7 of which provided type-specific diabetes prevalence data. Of 15 studies that included a non-autistic control group, 9 reported a higher diabetes prevalence among autistic persons, with a statistically significant difference in 4 studies. Studies demonstrating a higher diabetes prevalence in autistic groups had higher average study population sizes and reporting quality ratings.Conclusion:It is uncertain whether diabetes is significantly more prevalent in autistic persons relative to their non-autistic peers, though larger studies suggest a trend in this direction. Nevertheless, diabetes is a significant public health issue for the autistic community, which may require a tailored approach for identification and management. Prospero database registration number: CRD42019122176.
Building Information Modeling (BIM) in Enhancing the Applying of Knowledge Areas in the Architecture, Engineering and Construction (AEC) Industry
Authors: Maliha Mohammed N. , Tayeh Bassam A. , Abu Aisheh Yazan I. 
Published: January 2021

Background:
The Architecture, Engineering, and Construction (AEC) industry is one of the sectors that contribute the most to the Palestinian economy. However, it now suffers from many problems, one of which is not adopting new innovations, such as Building Information Modeling (BIM). BIM recently achieved far reaching consideration in the AEC industry.

Aim:
This research aimed to understand the contribution of BIM to the enhancement and application of Knowledge Areas (KAs) in the AEC industry in Palestine.

Methods:
A quantitative survey was utilized in the pilot study. Thirty copies of the questionnaire were dispersed to respondents from the target group. The completed questionnaires were analyzed to test for statistical validity and reliability. After the pilot study, the questionnaire was validated and dispersed to the entire sample, comprising respondents from the target group who were selected by convenience sampling. Eighty copies of the questionnaire were dispersed, and 71 copies of the questionnaire were obtained from the respondents with a response rate of 88.8%.

Results:
To draw meaningful results, the gathered information was analyzed by utilizing quantitative data analysis techniques, including the RII, Pearson correlation analysis, and Factor analysis.

Conclusion:
The results illustrated the extent of enhancing the application of KAs in the AEC industry using BIM technology from the highest to lowest as follows: Cost Management (CM), Time Management (TM), Resource Management (REM), Procurement Management (PROM), Scope Management (SCM), Stakeholder Management (STM), Integration Management (IM), Quality Management (QM), Communication Management (COM), Risk Management (RM), and Safety Management (SM). As an example, BIM is effectively applied to each KA, and high efficiency is achieved when BIM is applied to TM by 4D modeling; to CM by 5D modeling; to REM by collaboration; to PROM by quantity takeoff; to SCM by element-base; to STM and IM by using integrated project delivery; to QM by using clash detection; to COM by centralized, structured data management, and information flow; to RM by constructability; and to SM by automated safety code checking.
The Nurse as an Information Broker for Children with Terminal Illness: A Qualitative Study
Authors: Adistie Fanny , Mediani Henny S. , Lumbantobing Valentina B.M. , Maryam Nenden N.A. , Hendrawati Sri 
Published: January 2021

Background:
Providing care for children with a terminal illness is a great challenge for nurses and might be very complex. Several roles can be performed while providing nursing care.

Objective:
The aim of this study was to identify the roles of nurses in providing nursing care to children with terminal illness and explore the nurse's perspective on how they perform their role in caring for children with terminal illness.

Methods:
This research was conducted qualitatively with a content analysis approach. In-depth interviews with 8 nurses and focus group discussion with 7 nurses were the data collection methods used in this study. The sampling technique in this research is purposive sampling with inclusion criteria for nurses who were willing to participate in this research with a minimum education of diploma degree in nursing, and having at least 3 years of working experience in the pediatric ward.

Results:
Based on the nurses’ perspectives, their role as a communicator, counselor, collaborator, advocator, educator, and also as care provider make them an information broker for children with terminal illnesses and their families.

Conclusion:
In conclusion, while performing the roles, nurses must have good communication skills and knowledge related to the condition of the child as well as the ability to work with other healthcare teams with the purpose of providing holistic and comprehensive care for children with a terminal illness.
Perceptions on Abortion and Long-acting Contraceptive Use among Women of Reproductive Age in Selected Nigerian States: A Cross-sectional Study
Authors: Bolarinwa Obasanjo Afolabi , Victor Chima , Olagunju Olalekan , Saeed Balsam Qubais 
Published: January 2021

Background:
It is estimated that over 210 million pregnancies occur each year, with almost half of these unplanned. The evidence further shows that about 76 million of these unplanned pregnancies occur in the developing world, with 19% ending in induced abortion and 11% of these abortions being unsafe. In sub-Saharan Africa, 2.2 unplanned pregnancies occur each year, with many of these in Nigeria. Reports show that 760,000 abortions occur each year in Nigeria, resulting in about 20,000 deaths. Abortion is greatly stigmatized in Nigeria, and the lack of a legal framework to support access to abortion services necessitates women to seek abortion services in unsafe places. This study, therefore, examines the perception of women regarding abortion (prevalence and stigma) and long-acting contraceptive (LARC) use in Nigeria.

Methods:
We performed secondary data analysis of round 5 of performance monitoring and accountability (PMA) in seven states of Nigeria for women in reproductive age (n = 11,284). Responses with regard to abortion incidence, perceptions on stigmatization and LARC use were examined using chi-square (χ2) analysis and binary logistic regression models.

Results:
Socio-demographic factors examined were found to be significantly associated with the perception that abortion was common; however, women who were educated to any level were twice more likely to report abortion being common in their communities compared to women who agreed that abortion was shameful. Place of residence was a significant factor and women resident in rural areas were more likely to undergo an abortion (OR = 1.34, 95% CI= 1.21 – 1.48). Further, married women (OR = 15.18, 95% CI=7.40 – 31.11) were 15 times more likely to use LARC.

Conclusion:
Perceptions that abortion is common and that it is a shameful practice were found to be underlying contributors to the use of LARC in Nigeria. However, the most significant influence was found to be exerted by respondents’ socio-demographic characteristics. Therefore, government and implementing agencies must develop an intervention to scale-up the use of LARC in Nigeria, and the framework should consider how to tackle socio-demographic barriers to access of contraceptive uptake as this would not only help increase the contraceptive prevalence rate but also reduce mortality from abortions.