bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival
Authors:   CETLAM group, Cabezón M. , Malinverni R. , Bargay J. , Xicoy B. , Marcé S. , Garrido A. , Tormo M. , Arenillas L. , Coll R. , Borras J. , Jiménez M. J. , Hoyos M. , Valcárcel D. , Escoda L. , Vall-Llovera F. , Garcia A. , Font L. L. , Rámila E. , Buschbeck M. , Zamora L. 
Published: January 2021

Abstract
Background
Epigenetic therapy, using hypomethylating agents (HMA), is known to be effective in the treatment of high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) patients who are not suitable for intensive chemotherapy and/or allogeneic stem cell transplantation. However, response rates to HMA are low and there is an unmet need in finding prognostic and predictive biomarkers of treatment response and overall survival. We performed global methylation analysis of 75 patients with high-risk MDS and secondary AML who were included in CETLAM SMD-09 protocol, in which patients received HMA or intensive treatment according to age, comorbidities and cytogenetic.

Results
Unsupervised analysis of global methylation pattern at diagnosis did not allow patients to be differentiated according to the cytological subtype, cytogenetic groups, treatment response or patient outcome. However, after a supervised analysis we found a methylation signature defined by 200 probes, which allowed differentiating between patients responding and non-responding to azacitidine (AZA) treatment and a different methylation pattern also defined by 200 probes that allowed to differentiate patients according to their survival. On studying follow-up samples, we confirmed that AZA decreases global DNA methylation, but in our cohort the degree of methylation decrease did not correlate with the type of response. The methylation signature detected at diagnosis was not useful in treated samples to distinguish patients who were going to relapse or progress.

Conclusions
Our findings suggest that in a subset of specific CpGs, altered DNA methylation patterns at diagnosis may be useful as a biomarker for predicting AZA response and survival.
An Accurate Numerical Model Simulating Hysteretic Behavior of Reinforced Concrete Columns Irrespective of Types of Loading Protocols
Authors: Lee Chang Seok , Han Sang Whan 
Published: January 2021

AbstractIn older reinforced concrete (RC) buildings, columns are fragile elements that can induce collapse of entire buildings during earthquakes. An accurate assessment of the seismic vulnerability of RC buildings using nonlinear response history analyses requires an accurate numerical model. The peak-oriented hysteretic rule is often used in existing numerical models to simulate the hysteretic behavior of RC members, with predefined backbone curves and cyclic deterioration. A monotonic backbone curve is commonly constructed from a cyclic envelope. Because cyclic envelope varies according to loading protocols, particularly in a softening branch, it is difficult to obtain a unique backbone curve irrespective of loading protocols. In addition, cyclic deterioration parameters irrespective of loading protocols cannot be found because these parameters are estimated with respect to the backbone curves. Modeling parameters of existing numerical models can also vary with respect to loading protocol. The objective of this study is to propose a loading protocol-independent numerical model that does not require estimates of modeling parameters specifically tuned for a certain loading protocol. The accuracy of the proposed model is verified by comparing the simulated and measured cyclic curves of different sets of identical RC column specimens under various loading protocols.
Assessing fidelity to family-based treatment: an exploratory examination of expert, therapist, parent, and peer ratings
Authors: Couturier Jennifer , Kimber Melissa , Barwick Melanie , McVey Gail , Findlay Sheri , Webb Cheryl , Niccols Alison , Lock James 
Published: January 2021

Abstract
Introduction
Fidelity is an essential component for evaluating the clinical and implementation outcomes related to delivery of evidence-based practices (EBPs). Effective measurement of fidelity requires clinical buy-in, and as such, requires a process that is not burdensome for clinicians and managers. As part of a larger implementation study, we examined fidelity to Family-Based Treatment (FBT) measured by several different raters including an expert, a peer, therapists themselves, and parents, with a goal of determining a pragmatic, reliable and efficient method to capture treatment fidelity to FBT.

Methods
Each therapist audio-recorded at least one FBT case and submitted recordings from session 1, 2, and 3 from phase 1, plus one additional session from phase 1, two sessions from phase 2, and one session from phase 3. These submitted files were rated by an expert and a peer rater using a validated FBT fidelity measure. As well, therapists and parents rated fidelity immediately following each session and submitted ratings to the research team. Inter-observer reliability was calculated for each item using the intraclass correlation coefficient (ICC), comparing the expert ratings to ratings from each of the other raters (parents, therapists, and peer). Mean scale scores were compared using repeated measures ANOVA.

Results
Intraclass correlation coefficients revealed that agreement was the best between expert and peer, with excellent, good, or fair agreement in 7 of 13 items from session 1, 2 and 3. There were only four such values when comparing expert to parent agreement, and two such values comparing expert to therapist ratings. The rest of the ICC values indicated poor agreement. Scale level analysis indicated that expert fidelity ratings for phase 1 treatment sessions scores were significantly higher than the peer ratings and, that parent fidelity ratings tended to be significantly higher than the other raters across all three treatment phases. There were no significant differences between expert and therapist mean scores.

Conclusions
There may be challenges inherent in parents rating fidelity accurately. Peer rating or therapist self-rating may be considered pragmatic, efficient, and reliable approaches to fidelity assessment for real-world clinical settings.
Epiretinal membrane surgery outcome in eyes with abnormalities of the central bouquet
Authors: Brinkmann Max P. , Michels Stephan , Brinkmann Carolin , Rommel Felix , Ranjbar Mahdy , Graf Johansen Nicole , Becker Matthias 
Published: January 2021

Abstract
Background
Clinical studies have shown that epiretinal membranes (ERM) as well as abnormalities of the central foveal bouquet (CB) can be classified in different stages according to their morphological appearance. Furthermore, visual acuity correlates with the different stages of these features. The present study evaluated how these findings change after the surgical removal of the ERM and their impact on functional outcomes.

Methods
In this retrospective study eyes with ERM were evaluated by SD-OCT scans before and after pars plana vitrectomy (PPV) with macular ERM and internal limiting membrane (ILM) peeling. CB abnormalities were classified according to their morphological appearance from stage 0 (no abnormalities) to stage 3 (acquired vitelliform lesion). ERMs were classified ranging from stage 0 (absence of ERM) to stage 4 (ERM with significant anatomic disruption of macula). Changes in morphology were correlated with visual acuity before and after surgery.

Results
151 eyes were included into the study. Before surgery 27.2% (n = 41) of eyes showed CB abnormalities with stage 1 being the most common (11.9%, n = 18). Before surgery ERM was seen in all patients. The most common form was stage 1 (28.5%, n = 43), followed by stage 3 (27.8%, n = 42) and 2 (25.2%, n = 38). Only 18.5% (n = 28) presented with stage 4 ERM. The mean BCVA was 0.42 (logMAR) before and increased to 0.19 (logMAR) 8 weeks after vitrectomy (95% CI 0.20–0.28; p < 0.001). Patients who suffered from CB abnormalities had less increase in BCVA than patients who had no evidence of CB (0.28 vs. 0.14 logMAR; p < 0.001). Of all the patients with CB abnormalities at baseline, 68% had lower CB grading after the surgery (n = 28; 95% CI; p < 0.001). All patients showed an improvement of their ERM grading, with 98.7% reaching stage 0 (n = 151 vs. n = 149; 95% CI; p < 0.001).

Conclusions
The study indicates that the presence of CB abnormalities correlates with worse visual function. They are furthermore associated with worse visual outcomes after PPV with ERM and ILM peeling. These findings are valuable for deciding on PPV in patients with ERM.
Rethinking success, integrity, and culture in research (part 1) — a multi-actor qualitative study on success in science
Authors: Aubert Bonn Noémie , Pinxten Wim 
Published: January 2021

Abstract
Background
Success shapes the lives and careers of scientists. But success in science is difficult to define, let alone to translate in indicators that can be used for assessment. In the past few years, several groups expressed their dissatisfaction with the indicators currently used for assessing researchers. But given the lack of agreement on what should constitute success in science, most propositions remain unanswered. This paper aims to complement our understanding of success in science and to document areas of tension and conflict in research assessments.

Methods
We conducted semi-structured interviews and focus groups with policy makers, funders, institution leaders, editors or publishers, research integrity office members, research integrity community members, laboratory technicians, researchers, research students, and former-researchers who changed career to inquire on the topics of success, integrity, and responsibilities in science. We used the Flemish biomedical landscape as a baseline to be able to grasp the views of interacting and complementary actors in a system setting.

Results
Given the breadth of our results, we divided our findings in a two-paper series, with the current paper focusing on what defines and determines success in science. Respondents depicted success as a multi-factorial, context-dependent, and mutable construct. Success appeared to be an interaction between characteristics from the researcher (Who), research outputs (What), processes (How), and luck. Interviewees noted that current research assessments overvalued outputs but largely ignored the processes deemed essential for research quality and integrity. Interviewees suggested that science needs a diversity of indicators that are transparent, robust, and valid, and that also allow a balanced and diverse view of success; that assessment of scientists should not blindly depend on metrics but also value human input; and that quality should be valued over quantity.

Conclusions
The objective of research assessments may be to encourage good researchers, to benefit society, or simply to advance science. Yet we show that current assessments fall short on each of these objectives. Open and transparent inter-actor dialogue is needed to understand what research assessments aim for and how they can best achieve their objective.

Study Registration
osf.io/33v3m.
The value of cervical MRI in surgical lumbar canal stenosis patients
Authors: Abdalla Omar Youssef , Al-Shami Hieder , Maghraby Heba Medhat , Enayet Abdelrhman 
Published: January 2021

Abstract
Background
The prevalence of cervical canal stenosis alone is estimated to be present in 4.9% of the adult population. Co-existence of dual pathology may complicate clinical presentation and necessitates a wise and individually based decision process.

Objectives
To estimate the co-existence of cervical canal stenosis in surgical lumbar canal stenosis patients and its reflection on decision-making regarding surgery.

Methods
It is a prospective study that was conducted on 70 cases with symptomatic lumbar canal stenosis by investigating them for cervical canal stenosis clinically and radiologically.

Results
The co-existence of cervical and lumbar canal stenoses was seen in 62 cases (88.57%); cases with relative cervical stenosis were 25 (35.714%) and absolute cervical stenosis was 37 (52.857%). Cases with no cervical stenosis were 8 (11.428%) and cases with relative lumbar stenosis were 22 (31.428%), while cases with absolute lumbar stenosis were 48 (68.571%). Cases with symptomatic cervical canal stenosis were 30 (42.857%). Cases with asymptomtic cervical canal stenosis were 32 (45.71%).

Conclusion
Tandem spinal stenosis (TSS) is not uncommon and MRI cervical spine should be done for every lumbar canal stenosis patient especially if indicated by history or clinical examination.
Ischemia-modified albumin and fibulin-5 as diagnostic and prognostic markers for acute cerebrovascular disease
Authors: Elshony Hosna S. , Okda Mohammed A. , El-Kabany Rasha A. 
Published: January 2021

Abstract
Background
Fibulin-5 and ischemia-modified albumin (IMA) levels increase in acute phase of cerebrovascular diseases, yet data regarding their levels in various stroke subtypes and correlation with severity and prognosis are still insufficient. This work aims to evaluate serum IMA and fibulin-5 as markers for early detection and predicting prognosis in acute cerebrovascular disease.

Method
This case-control study was done on 100 patients with first time stroke, assessed by the National Institute of Health Stroke Scale (NIHSS) and Glasgow Coma Scale (GCS) within the first 24 h after stroke event, lesion volume was calculated, serum fibulin-5 and IMA levels were measured in the first few hours of stroke, and their levels were compared with levels measured in 75 control subjects. Three months later, stroke patients were assessed by the modified Rankin Scale (MRS).

Results
Fibulin-5 and IMA were significantly higher in the patient than in the control group and were positively correlated with lesion volume and NIHSS score but inversely correlated with GCS score. Fibulin-5 was statistically higher in hemorrhage group, whereas IMA was statistically higher in infarction group. MRS score was positively correlated with fibulin-5 levels at onset of stroke but not with IMA.

Conclusion
Fibulin-5 and ischemia-modified albumin are increased during the acute stroke phase and correlated with severity of stroke, but only fibulin-5 shows significant correlation with prognosis.
Randomized Phase II Study of Bevacizumab in Combination With Carboplatin Plus Paclitaxel in Patients With Previously Untreated Advanced Mucosal Melanoma
Authors: Yan Xieqiao , Sheng Xinan , Chi Zhihong , Si Lu , Cui Chuanliang , Kong Yan , Tang Bixia , Mao Lili , Wang Xuan , Lian Bin , Li Siming , Bai Xue , Zhou Li , Dai Jie , Yao Hong , Guo Jun 
Published: January 2021

PURPOSE Mucosal melanoma (MM) is a highly vascularized tumor with an extremely poor prognosis. In this randomized, open-label, phase II study, we characterized the efficacy and safety of bevacizumab in combination with carboplatin plus paclitaxel (CPB) in patients with previously untreated advanced MM. PATIENTS AND METHODS Patients were randomly assigned in a 2:1 ratio to receive carboplatin (area under the curve, 5) plus paclitaxel (175 mg/m2) once every 4 weeks in combination with (CPB arm, 5 mg/kg) or without (CP arm) bevacizumab once every 2 weeks. Progression-free survival (PFS) was the primary end point. Secondary end points included overall survival (OS), objective response rate, and adverse events. RESULTS We recruited 114 patients to our study. The median PFS was significantly longer in the CPB arm (4.8 months; 95% CI, 3.6 to 6.0 months) than in the CP arm (3.0 months; 95% CI, 1.7 to 4.3 months) (hazard ratio, 0.461; 95% CI, 0.306 to 0.695; P < .001). Objective response rates were 19.7% and 13.2%, respectively ( P = .384). The median OS was also significantly longer in the CPB arm than in the CP arm (13.6 v 9.0 months; hazard ratio, 0.611; 95% CI, 0.407 to 0.917; P = .017). No new safety signals were observed. CONCLUSION PFS and OS were significantly better in patients with metastatic MM who received bevacizumab in addition to CPB than in those who received CPB alone. A phase III study should be performed to confirm these benefits (ClinicalTrials.gov identifier: NCT02023710 ).
Phase I/II Study of Capmatinib Plus Erlotinib in Patients With MET-Positive Non–Small-Cell Lung Cancer
Authors: McCoach Caroline E. , Yu Aiming , Gandara David R. , Riess Jonathan W. , Vang Daniel P. , Li Tiahong , Lara Primo N. , Gubens Matthew , Lara Frances , Mack Philip C. , Beckett Laurel A. , Kelly Karen 
Published: January 2021

PURPOSE MET dysregulation is an oncogenic driver in non–small-cell lung cancer (NSCLC), as well as a mechanism of TKI (tyrosine kinase inhibitor) resistance in patients with epidermal growth factor receptor ( EGFR)–mutated disease. This study was conducted to determine safety and preliminary efficacy of the combination EGFR and MET inhibitors as a strategy to overcome and/or delay EGFR-TKI resistance. METHODS A standard 3 + 3 dose-escalation trial of capmatinib in combination with erlotinib in patients with MET-positive NSCLC was used. Eighteen patients in the dose-escalation cohort received 100-600 mg twice daily of capmatinib with 100-150 mg daily of erlotinib. There were two dose-expansion cohorts. Cohort A included 12 patients with EGFR-mutant tumors resistant to TKIs. Cohort B included five patients with EGFR wild-type tumors. The primary outcome was to assess safety and determine the recommended phase II dose (RP2D) of the combination. RESULTS The most common adverse events of any grade were rash (62.9%), fatigue (51%), and nausea (45.7%). Capmatinib exhibited nonlinear pharmacokinetics combined with erlotinib, while showing no significant drug interactions. The RP2D was 400 mg twice daily capmatinib tablets with 150 mg daily erlotinib. The overall response rate (ORR) and DCR in dose-expansion cohort A was 50% and 50%, respectively. In cohort B, the ORR and disease control rate were 75% and 75%. CONCLUSION Capmatinib in combination with erlotinib demonstrated safety profiles consistent with prior studies. We observed efficacy in specific patient populations. Continued evaluation of capmatinib plus EGFR-TKIs is warranted in patients with EGFR activating mutations.
Missing in Action
Authors: Giddings Paula J. 
Published: January 2021

AbstractIn 1930, Ida B. Wells-Barnett was surprised and disappointed to find that, despite her pioneering role as an anti-lynching activist and a founder of the NAACP, her name was not included in a contemporary Black history text by Carter G. Woodson, the “Father of Negro History.” This essay interrogates the social and political forces, beyond conventional racism and sexism, that marginalized Wells-Barnett’s place in history.
Art Comes for the Archbishop
Authors: Calvo Luz 
Published: January 2021

AbstractInspired by the Chicana feminist artist Alma López’s Our Lady (1999), this essay explores Chicana cultural and psychic investments in representations of the Virgin of Guadalupe. As an image of the suffering mother, the Virgin of Guadalupe is omnipresent in Mexican-American visual culture. Her image has been refigured by several generations of Chicana feminist artists, including Alma López. Chicana feminist reclaiming of the Virgin, however, has been fraught with controversy. Chicana feminist cultural work—such as the art of Alma López, performances by Selena Quintanilla, and writings by Sandra Cisneros and John Rechy—expand the queer and Chicana identifications and desires, and contest narrow, patriarchal nationalisms. By deploying critical race psychoanalysis and semiotics, we can unpack the libidinal investments in the brown female body, as seen in both in popular investments in protecting the Catholic version of the Virgin of Guadalupe and Chicana feminist reinterpretations.
Cosmopolitan Whiteness
Authors: Saraswati L. Ayu 
Published: January 2021

AbstractPrevious scholarship on the immense popularity of skin-whitening frames this practice as revealing women’s desire to emulate whiteness and upper class White populations. Others have focused on whitening practices to highlight the working of racialized color hierarchy and European/Euro-American hegemony in local and global contexts. This article breaks away from these established theoretical trajectories by arguing that desire for “whiteness” is not the same as desire for “Caucasian whiteness.” Examining advertisements for skin-whitening products in the Indonesian version of Cosmopolitan and skin-tanning products in the American version of Cosmopolitan, the author points out the construction of “cosmopolitan whiteness.” Whiteness is not simply racialized or nationalized as such, but transnationalized. Whiteness is represented as “cosmopolitanness,” embodying transnational mobility.
Mind the gap: life-threatening retropharyngeal haematoma resulting in acute airway obstruction following blunt trauma by closing train carriage doors
Authors: Patel Shaneil V , Reza Abbas , Rice Scott R 
Published: January 2021

Delayed life-threatening airway obstruction due to venous injury following blunt, non-penetrative trauma to the neck. A rare case of rapid force, blunt trauma by closing train carriage doors, leading to injury to the left internal jugular vein, subsequent retropharyngeal haematoma and airway obstruction. There was a significant delay of a few hours between injury and acute deterioration. Initial dual phase CT (unenhanced and arterial) studies identified the large retropharyngeal haematoma but the assessment of the source was inconclusive likely due to the venous injury becoming compressed by the swelling/haematoma at the time of investigation. Subsequent triple phase (unenhanced, arterial and venous) studies were performed identifying a flap in the left internal jugular vein as the likely site of vascular injury. A venous origin of haemorrhage supported the patients delayed onset of symptoms following the injury. We suggest with blunt force trauma to the neck, in the context of suspicion of haematoma and airway compromise, the radiologist should consider protocolling a triple phase (unenhanced, arterial and venous) angiographic study.