bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Packaged and Reusable Hydrogel Strain Sensor with Conformal Adhesion to Skin for Human Motions Monitoring
Authors: Zhao Meijin , Zhang Wenshuai , Wang Dan , Sun Peipei , Tao Yuanyuan , Xu Lingxiao , Shi Lei 
Published: December 2021

AbstractFlexible strain sensors based on conductive hydrogels show great potential in wearable devices, electronic skins, and bioelectronics. However, hydrogels inevitably exhibit poor durability for long‐term usage due to the water loss by evaporation. Herein, an external packaging strategy is demonstrated for fabricating sandwich‐like packaged hydrogel strain sensors (PHSSs) through the combination of conductive hydrogel injection and subsequent packaging via a photopolymerization procedure. The as‐prepared PHSS consists of two functional parts, internal hydrogel conducting wires exhibiting excellent linear strain sensing performance as sensing element and an external packaging hydrogel layer with good transparency and conformal adhesion to human skin. Thanks to these intriguing merits, the PHSS possesses the capability to detect both the large‐scale and subtle human motions precisely. Particularly, compared to conventional naked hydrogel strain sensors, the lifespan of PHSS is proved to be remarkably enlarged benefiting from the protective effect of external packaging layer towards the embedded hydrogel sensing element. Besides, the swelling property of external packaging layer even after severe dehydration enables the sensor to be reusable. This work provides a new approach for the fabrication of flexible strain sensors with enhanced lifespan and good reusability.
Disorder‐Induced Dispersive Magneto‐Electroluminescence of Blue Emitters in Organic Light Emitting Diodes
Authors: Pan Xin , Kwon Ohyun , Khanal Dipak Raj , Choi Byoungki , Vardeny Zeev Valy 
Published: December 2021

AbstractDisorder‐induced inhomogeneity in blue‐fluorescent‐based organic light‐emitting diodes (OLEDs) based on mixtures of host and guest molecules is studied using magneto‐electroluminescence, MEL(B), response based on the so called “Δg mechanism”, where Δg is the difference in the Landé g‐factor of electrons and holes. The disorder in the organic active layer is manifested by a unique non‐Lorentzian MEL(B) response that is analyzed using a distribution of spin lifetimes for the injected electron–hole pairs that is determined by a dispersive parameter, α (<1). The carriers’ inhomogeneous response also influences the free carrier absorption spectrum, which shows characteristic properties described by a dispersive parameter β (<1). From the measured MEL(B) response at various injection conditions it is found that α is robust at increasing current density showing that the inhomogeneity is governed by intrinsic disorder in the device active layer. Also the obtained increase in α at low temperature indicates that the organic layer becomes more ordered, where longer‐lived electron–hole spin pairs are formed.
Sulfisoxazole Elicits Robust Antitumour Immune Response Along with Immune Checkpoint Therapy by Inhibiting Exosomal PD‐L1
Authors: Shin Jung Min , Lee Chan‐Hyeong , Son Soyoung , Kim Chan Ho , Lee Jae Ah , Ko Hyewon , Shin Sol , Song Seok Ho , Park Seong‐Sik , Bae Ju‐Hyun , Park Ju‐Mi , Choe Eun‐Ji , Baek Moon‐Chang , Park Jae Hyung 
Published: December 2021

AbstractDespite their potent antitumor activity, clinical application of immune checkpoint inhibitors has been significantly limited by their poor response rates (<30%) in cancer patients, primarily due to immunosuppressive tumor microenvironments. As a representative immune escape mechanism, cancer‐derived exosomes have recently been demonstrated to exhaust CD8+ cytotoxic T cells. Here, it is reported that sulfisoxazole, a sulfonamide antibacterial, significantly decreases the exosomal PD‐L1 level in blood when orally administered to the tumor‐bearing mice. Consequently, sulfisoxazole effectively reinvigorates exhausted T cells, thereby eliciting robust antitumor effects in combination with anti‐PD‐1 antibody. Overall, sulfisoxazole regulates immunosuppression through the inhibition of exosomal PD‐L1, implying its potential to improve the response rate of anti‐PD‐1 antibodies.
Precise Molecular Engineering of Type I Photosensitizers with Near‐Infrared Aggregation‐Induced Emission for Image‐Guided Photodynamic Killing of Multidrug‐Resistant Bacteria
Authors: Xiao Peihong , Shen Zipeng , Wang Deliang , Pan Yinzhen , Li Ying , Gong Junyi , Wang Lei , Wang Dong , Tang Ben Zhong 
Published: December 2021

AbstractMultidrug resistance (MDR) bacteria pose a serious threat to human health. The development of alternative treatment modalities and therapeutic agents for treating MDR bacteria‐caused infections remains a global challenge. Herein, a series of near‐infrared (NIR) anion–π+ photosensitizers featuring aggregation‐induced emission (AIE‐PSs) are rationally designed and successfully developed for broad‐spectrum MDR bacteria eradication. Due to the strong intramolecular charge transfer (ICT) and enhanced highly efficient intersystem crossing (ISC), these electron‐rich anion–π+ AIE‐PSs show boosted type I reactive oxygen species (ROS) generation capability involving hydroxyl radicals and superoxide anion radicals, and up to 99% photodynamic killing efficacy is achieved for both Methicillin‐resistant Staphylococcus aureus (MRSA) and multidrug resistant Escherichia coli (MDR E. coli) under a low dose white light irradiation (16 mW cm−2). In vivo experiments confirm that one of these AIE‐PSs exhibit excellent therapeutic performance in curing MRSA or MDR E. coli‐infected wounds with negligible side‐effects. The study would thus provide useful guidance for the rational design of high‐performance type I AIE‐PSs to overcome antibiotic resistance.
Diskussion zum Erfordernis der jährlichen Hauptprüfung geschützter Holzbrücken
Authors: Koch Johannes , Simon Antje , Arndt Ralf W. , Jahreis Markus G. 
Published: December 2021

AbstractBauen mit Holz ist im Hinblick auf die klimapolitischen Zielsetzungen Deutschlands zukunftsweisend und unverzichtbar. Brückenbauwerke werden hierzulande jedoch nur selten in Holzbauweise errichtet, da sie aufgrund einiger schlecht geplanter Beispiele unter dem Generalverdacht stehen, nicht dauerhaft zu sein. Daher fordert der Bund in seinen Regelwerken für nahezu alle Holzbrücken eine jährliche Hauptprüfung. Diese Forderung stellt einen erheblichen Wettbewerbsnachteil gegenüber Brücken aus anderen Baustoffen dar, für die nur im sechsjährigen Turnus eine Hauptprüfung vorgeschrieben ist. Um auf der Grundlage belastbarer Messdaten dem Imageverlust der Holzbauweise im Brückenbau zu begegnen, wurden im Forschungsvorhaben Protected Timber Bridges (ProTimB) Langzeitmessungen der Holzfeuchte an neun geschützten Holzbrücken in Deutschland durchgeführt. Über 2,5–6 Jahre wurde die Holzfeuchteentwicklung an Brücken verschiedener Bauarten mit unterschiedlichen kleinklimatischen Randbedingungen aufgezeichnet. Das Ziel der Monitorings war es, die Wirksamkeit eines fachgerechten konstruktiven Holzschutzes aufzuzeigen und den Einfluss eines nahen Gewässers und einer Sprühnebelbeaufschlagung auf die Entwicklung der Holzfeuchte zu untersuchen. Der vorliegende Beitrag fasst die wesentlichen Ergebnisse der Messungen zusammen. Auf Basis der gewonnenen Erkenntnisse wird das Erfordernis einer jährlichen Hauptprüfung für geschützte Holzbrücken über Gewässern diskutiert.
Alashanoids O–S, seco‐Humulane and Eremophilane Sesquiterpenoids from Syringa pinnatifolia
Authors: Liu Changxin , Jiao Shungang , Li Anni , Xu Jixuan , Zhou Xiaochun , Chen Suyile , Tu Pengfei , Huang Luqi , Chai Xingyun 
Published: December 2021

AbstractFive new sesquiterpenoids, alashanoids O–S (1–5), along with three known analogs (6–8) were isolated from the peeled stems of Syringa pinnatifolia. Their structures were elucidated by analysis of extensive spectroscopic data including ESI‐MS, 1D, 2D NMR. The absolute configurations were determined by comparing its experimental and calculated electronic circular dichroism, calculated OR, calculated NMR, and single crystal X‐ray diffraction data analysis. Compounds 1 and 2 belong to the seco‐humulane type and possess a rare 13‐membered oxygen heterocycle framework, and 3–5 belong to eremophilane‐type. Compounds 1, 2, and 5 showed inhibitory effects against NO production in LPS‐induced RAW264.7 macrophage cells with its IC50 values of 11.86±2.34, 72.08±7.72, and 69.22±15.29 μM, respectively, compared with the positive control indomethacin (IC50=31.52 μM).
Convenient Synthesis of Alternatively Bridged Tryptophan Ketopiperazines and Their Activities against Trypanosomatid Parasites
Authors: Cockram  Peter E. , Turner Callum A. , Slawin Alexandra M. Z. , Smith Terry K. 
Published: December 2021

AbstractThere is an urgent need for the development of new treatments against trypanosomatid parasites; the causative agents of some of the most debilitating diseases in the developing world. This work targets an interesting 6‐5‐6‐6 fused carboline scaffold, accessing a range of substituted derivatives through stereospecific intramolecular Pictet–Spengler condensation. Modification of the cyclisation conditions allowed retention of the carbamate protecting group and gave insight into the reaction mechanism. Compounds’ bioactivities were measured against T. brucei, T. cruzi, L. major and HeLa cells. We have identified promising pan‐trypanocidal lead compounds based on the core scaffold, and highlight key SAR trends which will be useful for the future development of these compounds as potent trypanocidal agents.
Dietary supplement use by individuals living with and beyond breast, prostate, and colorectal cancer: A cross‐sectional survey
Authors: Conway Rana E. , Rigler Freyja V. , Croker Helen A. , Lally Phillippa J. , Beeken Rebecca J. , Fisher Abi 
Published: December 2021

BackgroundDietary supplements (DSs) are not recommended for the prevention of cancer recurrence. Although DS use is common in individuals living with and beyond cancer, its associations with beliefs about reduced cancer recurrence risk and demographic and health behaviors are unclear.MethodsAdults (18 years old or older) who had been diagnosed with breast, prostate, or colorectal cancer were recruited through National Health Service sites in Essex and London. Participants completed a mailed survey and telephone or online 24‐hour dietary recalls (MyFood24). Supplement use was collected during the dietary recalls. Associations between DS use and demographics, health behaviors, and beliefs about DSs and cancer were explored.ResultsNineteen percent of 1049 individuals believed that DSs were important for the reduction of cancer recurrence risk, and 40% of individuals reported DS use. DS use was positively associated with being female (odds ratio [OR], 2.48; confidence interval [CI], 1.72‐3.56), meeting 5‐a‐day fruit and vegetable recommendations (OR, 1.36; CI, 1.02‐1.82), and believing that DSs were important for reducing cancer recurrence risk (OR, 3.13; CI, 2.35‐4.18). DS use was negatively associated with having obesity (OR, 0.58; CI, 0.38‐0.87). The most commonly taken DSs overall were fish oils (taken by 13%). Calcium with or without vitamin D was the most common DS taken by individuals with breast cancer (15%).ConclusionsDS use by individuals living with and beyond cancer is associated with demographic factors and health behaviors. A belief that DSs reduce the risk of cancer recurrence is common and positively associated with DS use. There is a need for health care professionals to provide advice about DS use and cancer recurrence risk.
3D Flower‐Like Zinc Cobaltite for Electrocatalytic Reduction of Nitrate to Ammonia under Ambient Conditions
Authors: Huang Pingping , Fan Tingting , Ma Xintao , Zhang Jiguang , Zhang Yanping , Chen Zhou , Yi Xiaodong 
Published: December 2021

AbstractNitrate (NO3−) as a common pollutant of groundwater causes drinking water safety problems and seriously endangers people‘s health. Electrochemical reduction of nitrate to ammonia under ambient condition is a green and significant route to reduce the concentration of NO3− and produce ammonia (NH3), known as a complement to the Haber–Bosch reaction. Currently, noble‐metal electrocatalysts are often used in electrochemical reduction of NO3−, but high cost and scarcity limited their application. Herein, three‐dimensional (3D) flower‐like zinc cobaltite (ZnCo2O4) electrocatalyst was developed to convert nitrate into ammonia at room temperature. The NH3 yield rate could reach up to around 2100 μg mg−1 h−1 at a potential of −0.6 V vs. reversible hydrogen electrode (RHE), which was around 2.0 times higher than that of pristine Co3O4. In addition, the NH3 faradaic efficiency of ZnCo2O4 electrocatalyst could reach around 95.4 % at potential of −0.4 V vs. RHE with good structural and morphological stability, which surpassed most reported non‐noble metal‐based electrocatalysts. Further studies concluded that the improved activity of electrocatalytic NO3− reduction was ascribed to the existence of abundant active sites and the charge transfer from Co atoms to Zn atoms after Zn doping. Importantly, this work opens a new path for the development of Co‐based materials as electrocatalysts for reducing nitrate to ammonia.
Guanine‐Based G‐Quadruplexes Templated by Various Cations toward Potential Use as Single‐Ion Conductors
Authors: Kang So‐Huei , Lee Kyung Min , Cho Seok‐Kyu , Lee Ji Eun , Won Donghoo , Lee Sang‐Young , Kwak Sang Kyu , Yang Changduk 
Published: December 2021

AbstractInspired by the atomic‐sized, shape‐regulated features of G‐quadruplexes comprising guanine motifs with a monovalent metal cation, the G‐quadruplex‐forming ability, and properties of a guanine‐based π‐conjugated Y2 molecule containing bithiophene and peripheral dodecyl chain units in the presence of various cation salts (Li+, Na+, K+, and Mg2+) were exploited. A series of structural characterization revealed that Y2 yielded desirable G‐quadruplexes with all the tested cations as a consequence of the combination of a hydrogen‐bonded cyclic G‐quartet, π‐stacking, and cation‐dipole interactions. The radius and nature of the coordinating cations crucially affected the structural characteristics of G‐quadruplexes, leading to variations in the ion migration ability inside the cavity of the G‐quadruplex (Li+>Na+>K+>Mg2+), as characterized through theoretical and experimental investigations. These results not only improve the understanding of G‐quadruplex self‐assemblies based on guanine but also provide an impetus for their diverse potential applications, especially in the field of Li batteries.
Nocardiosis diagnosed on bronchoalveolar lavage: Role of cytopathology
Authors: Christensen Bianca B. , Moran Jakob M. T. , Torous Vanda F. 
Published: December 2021

AbstractNocardia are gram‐positive, filamentous bacteria that have the potential to cause serious disease, particularly in immunocompromised patients. Nocardia may cause a complex clinical picture, with radiologic features that can mimic other infectious organisms or malignancy. The organisms are not easily identified on cytologic examination given their weak staining with routine preparations and because they may be obscured by the associated inflammatory exudate. However, recognition of subtle features and a high index of suspicion in the appropriate clinical setting can lead to the appropriate triaging of material for ancillary stains and confirmatory microbiology tests. We herein present three cases of nocardiosis diagnosed on bronchoalveolar lavage in order to discuss the clinical presentation and cytomorphologic features with emphasis on the role of cytopathologists in facilitating timely diagnosis and helping direct appropriate management.
Metastatic mesonephric‐like endometrial adenocarcinoma diagnosed on transbronchial needle aspirate cytology
Authors: Hardy Naomi L. , Staats Paul N. 
Published: December 2021

AbstractMesonephric‐like adenocarcinoma is a relatively rare neoplasm with morphology similar to mesonephric adenocarcinoma but unassociated with mesonephric remnants. Its relatively recent description and rarity make it difficult to diagnose, but it has a high rate of distant metastasis, making distinction from endometrioid carcinoma important. Descriptions of its cytologic features are particularly limited. We describe a case of mesonephric‐like adenocarcinoma diagnosed on transbronchial needle aspiration of the lung, that had been misdiagnosed as endometrioid endometrial adenocarcinoma on a prior hysterectomy. We discuss the characteristic cyto and histomorphology, immunoprofile, molecular alterations, and clinical significance of this uncommon tumor.
A unidirectional certificateless proxy re‐signature scheme based on lattice
Authors: Zhou YiHua , Dong SongShou , Yang YuGuang 
Published: December 2021

AbstractAs a kind of special digital signature, proxy re‐signature is becoming more and more important in transparent certification and management of group signatures. But most existing proxy re‐signature schemes cannot resist collusion attack. So we construct a scheme by using dual modulus technology and lattice structure. Dual modulus technology can ensure that our solution can resist various collusion attacks. Lattice structure can ensure that our scheme is secure in the postquantum era. Compared with the previous scheme, our scheme is unidirectional and certificateless, is secure in the post‐quantum era, does not require key escrow, can prevent man‐in‐the‐middle attacks, and can resist collusion attacks of proxy and delegatee as well as proxy and delegator. Moreover, our scheme is unidirectional and has better privacy. Furthermore, under the random oracle model, we prove that our scheme is strong nonforgeability against external attackers and the internal key generation center.
Prevalence, characterization, and antibiotic susceptibility of Cronobacter spp. in a milk powder processing environment: The first reported case in Serbia
Authors: Csorba Csaba , Pajić Marija , Blagojević Bojan , Forsythe Stephen , Radinović Miodrag , Velebit Branko 
Published: December 2021

AbstractCronobacter spp. are opportunistic foodborne pathogens that most often infect neonates and infants through contaminated powdered infant formula. No reports have been published in Serbia on the prevalence of Cronobacter spp. in powdered milk production environments. Consequently, this study aimed to determine the prevalence, molecular characterization, antimicrobial susceptibility, and biofilm‐forming ability of Cronobacter spp. isolated from a milk powder plant. Hundred samples were collected from the production facility. Fifteen Cronobacter sakazakii strains were isolated and identified, giving a contamination rate of 15%. Using multi‐locus sequence typing, the isolates were divided into five sequence types (STs). Cronobacter sakazakii ST4 (50%), ST1 (16.67%), and ST83 (16.67%) were the dominant STs isolated. A novel sequence type (ST759) was identified and registered in the Cronobacter MLST database. The results of the antibiotic susceptibility testing indicated that C. sakazakii strains were susceptible to piperacillin/tazobactam, ampicillin/sulbactam, and amoxicillin/clavulanate, especially to meropenem and cefotaxime. Most of the ST4 showed moderate‐to‐strong biofilm‐forming ability. The presence of clinically relevant isolates (ST4, ST1, ST83, and ST8) revealed that the production plant is likely a potential concern for public health. Finally, finding new sequence types like the one detected in this study (ST759) underlines evolving genetic changes in C. sakazakii.
Oligometastatic adenoid cystic carcinoma: Correlating tumor burden and time to treatment with outcomes
Authors: Tyan Kevin , Bae Ji Eun , Lorch Jochen H. , Margalit Danielle N. , Tishler Roy B. , Huynh Mai Anh , Jo Vickie Y. , Haddad Robert I. , Chau Nicole G. , Hanna Glenn J. , Schoenfeld Jonathan D. 
Published: December 2021

AbstractBackgroundThere is limited information on the management and outcomes of oligometastases (OM) in adenoid cystic carcinoma (ACC).MethodsRetrospective study of 42 patients with metastatic ACC of the head and neck. Imaging studies were analyzed to identify patients with OM (1–5 lesions) at any point during follow‐up.ResultsThere was radiographic evidence of OM in 33/42 (79%) patients. Eighteen patients had OM when treated for metastases, with median overall survival (OS) of 36.0 versus 9.2 years for patients with polymetastases (6+ lesions, HR 0.38, 95%CI 0.14–0.89). Earlier locally ablative treatment, but not systemic treatment, of patients with OM predicted improved survival 3 years after metastasis (HR 0.15, 95%CI 0.02–0.63) and postponed systemic treatment by 80 more months (HR 0.22, 95%CI 0.07–0.71).ConclusionsThere is a considerable population of ACC patients with detectable oligometastases, and early locally ablative treatment of oligometastases may be associated with improved outcomes.
Loss of bile salt export pump aggravates lipopolysaccharide‐induced liver injury in mice due to impaired hepatic endotoxin clearance
Authors: Remetic Jelena , Ghallab Ahmed , Hobloss Zaynab , Brackhagen Lisa , Hassan Reham , Myllys Maiju , Radun Richard , Mlitz Veronika , Zhu Ci , Baumgartner Maximilian , Schrottmaier Waltraud C. , Mussbacher Marion , Timelthaler Gerald , Scharnagl Hubert , Stojakovic Tatjana , Assinger Alice , Fuchs Claudia D. , Hengstler Jan G. , Trauner Michael 
Published: December 2021

Abstract

Background and Aims
Lipopolysaccharide (LPS) clearance is delayed in cholestatic liver diseases. While compromised clearance by Kupffer cells (KCs) is involved, the role of LPS uptake into hepatocytes and canalicular excretion remains unclear.

Approach and Results
Wild‐type (WT) and bile salt export pump (Bsep) knockout (KO) mice were challenged i.p. with LPS. Liver injury was assessed by serum biochemistry, histology, molecular inflammation markers, and immune cell infiltration. LPS concentrations were determined in liver tissue and bile. Subcellular kinetics of fluorescently labeled LPS was visualized by intravital two‐photon microscopy, and the findings in Bsep KO mice were compared to common bile duct–ligated (BDL) and multidrug resistance protein 2 (Mdr2) KO mice. Changes in gut microbiota composition were evaluated by 16S ribosomal RNA gene amplicon sequencing analysis. Bsep KO mice developed more pronounced LPS‐induced liver injury and inflammatory signaling, with subsequently enhanced production of proinflammatory cytokines and aggravated hepatic immune cell infiltration. After LPS administration, its concentrations were higher in liver but lower in bile of Bsep KO compared to WT mice. Intravital imaging of LPS showed a delayed clearance from sinusoidal blood with a basolateral uptake block into hepatocytes and reduced canalicular secretion. Moreover, LPS uptake into KCs was reduced. Similar findings with respect to hepatic LPS clearance were obtained in BDL and Mdr2 KO mice. Pretreatment with the microtubule inhibitor colchicine inhibited biliary excretion of LPS in WT mice, indicating that LPS clearance is microtubule‐dependent. Microbiota analysis showed no change of the gut microbiome between WT and Bsep KO mice at baseline but major changes upon LPS challenge in WT mice.

Conclusions
Absence of Bsep and cholestasis in general impair LPS clearance by a basolateral uptake block into hepatocytes and consequently less secretion into canaliculi. Impaired LPS removal aggravates hepatic inflammation in cholestasis.