bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PRODUK RUSAK TERHADAP BIAYA PRODUKSI PADA PT INDOFOOD SUKSES MAKMUR TBK
Authors: Juwita Rukmi , Fajaryanti Novi 
Published: August 2021

Pengendalian biaya produksi PT Indofood Sukses Makmur Tbk tidak hanya dikarenakan tingginya biaya bahan produksi. Tetapi, juga diakibatkan oleh produk rusak karena produk rusak baru diketahui setelah selesainya proses produksi. Tujuan dari penelitian ini untuk mengetahui pengaruh produk rusak terhadap kenaikan biaya produksi pada PT Indofood Sukses Makmur Tbk, sehingga tidak boleh dipandang sebagai masalah kecil agar tidak mempengaruhi kemampuan perusahaan dalam menghasilkan laba. Penggunaan metode dalam penelitian ini menggunakan metode kuantitatif dengan metode dua arah (two tailed). Hasil dari penelitian ini menunjukkan bahwa dalam persamaan regresi linier sederhana, setiap adanya kenaikan pada produk rusak sebesar 1 satuan, maka akan menaikkan atau menambah pengeluaran biaya produksi sebesar 33,684. Hal ini mengindikasikan bahwa setiap kenaikan produk rusak akan diikuti oleh kenaikan biaya produksi. “Kesimpulan dari dilakukannya penelitian ini yaitu, berdasarkan hasil uji t menunjukkan terdapat pengaruh yang signifikan antara produk rusak terhadap biaya produksi pada PT Indofood Sukses Makmur Tbk.”
Kata Kunci: Produk Rusak, Biaya Produksi.
Necrolytic migrating erythema as a diagnostic marker of pancreatic cancer
Authors: Тлиш М.М. , Наатыж Ж.Ю. , Кузнецова Т.Г. , Масько Д.И. , Козырь Я.В. 
Published: August 2021

К паранеопластическим синдромам относят заболевания, возникающие вследствие развития злокачественного новообразования и проявляющиеся симптомами, отдаленными от локализации самой опухоли и ее метастазов. Паранеопластические дерматозы – это многочисленная группа различных кожных проявлений, указывающих на возможность наличия опухоли, в том числе на ранней бессимптомной стадии развития. Одним из таких дерматозов является некролитическая мигрирующая эритема – патология кожи, имеющая ассоциацию с глюкагономой – альфа-клеточной опухолью поджелудочной железы, продуцирующей глюкагон. Представленное в статье описание клинического случая поможет улучшить понимание общности патогенетических аспектов между новообразованием и дерматозом, повысить онкологическую настороженность смежных специалистов и организовать эффективное междисциплинарное взаимодействие, улучшив качество жизни больных с опухоль-ассоциированными дерматозами.
Paraneoplastic syndromes include diseases that arise as a result of the development of a malignant neoplasm, manifested by symptoms that are remote from the localization of the tumor itself and its metastases. Paraneoplastic dermatoses are a large group of various skin manifestations that indicate the possibility of the presence of a tumor, including at an early asymptomatic stage of development. One of these dermatoses is necrolytic migrating erythema, a skin pathology associated with glucagonoma, an alpha – cell tumor of the pancreas that produces glucagon. The description of the clinical case presented in the article will help to improve the understanding of the common pathogenetic aspects between neoplasm and dermatosis, increase the oncological alertness of related specialists and organize effective interdisciplinary interaction, as a result, improving the quality of life of patients with tumor-associated dermatoses.
Sexual dysfunction as a consequence of coronavirus infection and quarantine due to the COVID-19 pandemic
Authors: Кибрик Н.Д. , Прокопенко Ю.П. 
Published: August 2021

В статье рассматриваются факторы, связанные с пандемией COVID-19, влияющие на интимную жизнь в постоянных парах. Исследования сексологов, психологов, психотерапевтов, репродуктологов, объединение разносторонних проявлений самооценки и взаимоотношений в интимной сфере демонстрируют довольно стройную картину явлений, связанных с психологическими, психическими и физиологическими запросами и возможностями как отдельных индивидуумов, так и макросоциальных образований. Отмечается зависимость проявлений сексуальности от напряженности инфекционной ситуации и карантинной политики. Предлагаются практические подходы для стабилизации и улучшения интимного поведения в супружеских парах при проживании в ограниченных условиях в присутствии других членов семьи, направленные на снижение риска депрессии и сексуальных расстройств в условиях самоограничения при пандемии COVID-19. В настоящее время, после зимы 2020-2021 гг., сопровождающейся прогрессивным снижением уровня заболеваемости и смертности, растет число людей с рациональным отношением к происходящему, которые активно адаптируются внутри семьи, а также в социуме.
The article examines the factors associated with the COVID-19 pandemic, affecting intimate life in long-term couples. Research by sexologists, psychologists, psychotherapists, reproductologists, combining versatile manifestations of self-esteem and relationships in the intimate sphere demonstrate a fairly harmonious picture of phenomena associated with psychological, mental and physiological needs and capabilities of both individuals and macrosocial formations. The dependence of manifestations of sexuality on the intensity of the infectious situation and quarantine policy is noted. Practical approaches are proposed to stabilize and improve intimate behavior in married couples living in limited conditions in the presence of other family members, aimed at reducing the risk of depression and sexual dysfunction in self-restraint conditions in the COVID-19 pandemic. Currently, after the winter of 2020-2021, accompanied by a progressive decrease in the level of morbidity and mortality, the number of people with a rational attitude to what is happening is growing, who are actively adapting within the family, as well as in society.
Pengaruh Lingkungan Sosial Terhadap Aktivitas Keagamaan Siswa MAS Plus Keterampilan Pondok Pesantren Nurul Fadhilah Deli Serdang
Authors: Nirwan Zulhamri, Salman Alfaris, Samsir Damanik, 
Published: August 2021

Pembinaan keberagamaan siswa pada dasarnya merupakan tanggung jawab dari orangtua dalam keluarga serta peran penting guru disekolah. Namun orangtua dan guru di skolah mempunyai keterbatasan dalam berbagai hal sehingga tanggung jawab pembinaan pendidikan yang dipikulkan kepadanya tidak semuanya dapat dilaksanakan. Orangtua menyerahkan anaknya untuk belajar di sekolah atau menuntut ilmu kepada guru mengaji. Namun demikian tanggung jawab pembinaan keberagamaan siswa ini tidak hanya tanggung jawab orangtua dan guru. Seluruh anggota masyarakat juga bertanggung jawab terhadap pembinaan pendidikan agama anggota masyarakat yang ada di lingkungannya. Selain itu efek pola hidup materialis tersebut merenggangkan ukhwah Islamiyah di antara sesama muslim, di mana masing-masing orang cenderung untuk individualis dan kehidupan manusia semakin gersang karena tidak memiliki pegangan hidup. Di sini pembinaan pendidikan agama semakin penting “karena kondisi masyarakat yang diperlukan sekarang adalah memiliki pola hidup yang sesuai bahkan dapat menguasai segala akibat yang ditimbulkan oleh kemajuan teknologi, agar manusia muslim tidak mengalami bahaya degradasi martabatnya.
Genetic Diversity, Correlations and Path Coefficient Analysis among the F5 Populations of Brassica Species
Authors: Kumar Sujon , Ali Barkat , Khaldun A. B. M. , Islam Shams Shaila , Uddin M. Shalim , Akanda M. A. Latif , Miah M. Shohidullah 
Published: August 2021

The present study was carried out to estimate heritability, genetic variability, correlation and genetic advance among F5 populations of ten genotypes in Brassica species. This study was executed following randomized complete block design (RCBD) with three replications during November 2017 to February 2018 at the experimental field of College of Agricultural Sciences, International University of Business Agriculture and Technology, Dhaka, Bangladesh. Aim of the research was to evaluate and select the best segregating genotypes for the yield and yield contributing traits towards variety development programs. Analysis of variance revealed that the genotypes were significantly different for all the characters studied. The relative phenotypic coefficient of variation (PCV) was higher than the genotypic coefficient of variation (GCV) for all the traits studied. The high GCV value was observed for the days to 50% flowering (FF), plant height (PH), primary branches per plant (PBP), pod per plant (PP) and seed yield per plant (SYP) that indicated a high broad-sense heritability. A significant positive correlation with seed yield per plant was found in days to 50% flowering (0.578**), the plant height, (0.787**), pod length (PL) (0.406*), seeds per plant (SP) (0.369*), pod per plant (0.697**) and hundred seeds weight (HSW) (0.500**), but significantly negative correlation found in primary branches per plant (-0.046*). The results of path coefficient analysis revealed that days to 50% flowering (0.287), plant height (0.407), pod length (0.919), seeds per plant (0.033), pod per plant (0.035) and hundred seeds weight (0.795) had a positive direct impact on seed yield per plant and thus it was indicated that these traits could be exploited for the enhancement of yield performance of Brassica species. This study showed that based on the agronomic performance execution, genotypes G2, G5, G6 and G8 might be proposed for future hybridization programs in Bangladesh followed by variety development activities.
Lipid Nanoparticles for Broad‐Spectrum Nucleic Acid Delivery
Authors: Hejdankova Zuzana , Vanek Vaclav , Sedlak Frantisek , Prochazka Jan , Diederichs Audrey , Kereïche Sami , Novotna Barbora , Budesinsky Milos , Birkus Gabriel , Grantz Saskova Klara , Cigler Petr 
Published: August 2021

AbstractLipid nanoparticles (LNPs) are the most advanced nonviral modality for nucleic acid (NA) delivery, and have recently gained enormous attention in the fields of RNA therapeutics and vaccine development. Here, ionizable adamantane‐based lipidoids named XMaNs, which circumvent the usual need for laborious optimization of LNP components for highly diverse types of NAs, are described. The non‐toxic XMaN6 lipidoid is highly versatile in entrapment and delivery of siRNA, mRNA, plasmid DNA, and a cyclic dinucleotide. XMaN6‐based LNPs efficiently deliver: 1) siRNA into human primary hepatocytes and cell lines that are hard‐to‐transfect; 2) mRNA into mouse liver; 3) plasmid DNA; 4) 2′,3′‐cGAMP into cells and activated the cGAS‐STING pathway three orders of magnitude more efficiently than 2′,3′‐cGAMP alone. To our knowledge, such universality in delivering different NA types has not been previously described and can accelerate translation of LNPs into the clinic.
Artificial Solid‐Electrolyte Interphase and Bamboo‐like N‐doped Carbon Nanotube Enabled Highly Rechargeable K‐CO2 Batteries
Authors: Li Xuelian , Qi Guicai , Zhang Junxiang , Cheng Jianli , Wang Bin 
Published: August 2021

AbstractMetal‐CO2 (Metal = Li, Na, K) batteries demonstrate an attractive strategy for utilizing the excessively released CO2 emissions into electrochemical energy storage devices. Among them, K‐CO2 batteries represent a promising energy storage system owing to high potential (2.48 V), high energy density, and earth‐abundant K resources. The cycle stability and electrochemical mechanism are still far beyond satisfactory because of the active potassium metal, although the first rechargeable K‐CO2 battery has been reported very recently. Herein, a high‐performance K‐CO2 battery is fabricated using passivated K anodes with artificial surface film and N‐doped carbon nanotubes cathodes. The battery shows high specific full discharge capacity (9436 mAh g−1), good rate capability with small overpotential gap (0.81 V at 50 mA g−1), and long cycle life (450 cycles or 3100 h with a curtailing capacity of 500 mAh g−1). The reaction of 3CO2 + 4K ⇋ 2K2CO3 + C reversibly occurs in the charge/discharge processes. Moreover, the assembled fiber‐shaped battery demonstrates a long operation time of 57 h and stable output under different bending conditions. This work provides an option for the possible recycling utilization of the CO2 in future space exploration.
Triangling, Anxiety, and Negative Self‐Image: The Mediating Role of Experiential Avoidance
Authors: Kurşuncu Mustafa Alperen , Baştemur Şule , Murdock Nancy 
Published: August 2021

The purpose of this study was to examine the mediating role of experiential avoidance in relationships between triangling configurations (balanced, mediator, cross‐generational coalition, scapegoating), anxiety, and negative self‐image (NS). The study sample comprised 381 university students. Data were collected from these participants using the Triangular Relationship Inventory (TRI), the Acceptance and Action Questionnaire‐II (AAQ‐II), the Negative Self and Anxiety Subscales of Brief Symptom Inventory (BSI), and a demographic information form. Findings of the structural equation modelling analyses revealed that triangling configurations and experiential avoidance (together) explained 36% of the variance in negative self and 44% of the variance in anxiety. Regarding indirect effects, it was found that experiential avoidance fully mediated the relationships between triangling configurations (except scapegoating), NS, and anxiety. The mediator type of triangling was found to play a protective role against NS and anxiety—the literature delineates the study findings.
Novel strategy for the demulsification of isolated sesame oil bodies by endogenous proteases
Authors: Chen Yeming , Li Huina , Zhang Caimeng , Kong Xiangzhen , Hua Yufei 
Published: August 2021

AbstractThis study aimed to develop a novel method to demulsify the isolated sesame oil bodies (OB) to recover oil by directly using the endogenous proteases in the isolated OB. In this study, it was found that the isolated sesame OB contained OB intrinsic proteins as well as extrinsic proteins. The OB intrinsic proteins at least included one 41 kDa steroleosin, two 39 kDa steroleosins, two 27 kDa caleosins, four 27 kDa oil body‐associated proteins, three 17 kDa oleosins, and four 15 kDa oleosins. As for the OB extrinsic proteins, the predominant ones were 11S globulins, followed by 2S albumins and 7S globulins. In addition, the OB extrinsic proteins contained sesame endogenous proteases, predominantly including aspartic endopeptidases, subtilisin‐like proteases, serine carboxypeptidases, and metalloendopeptidase. The results revealed that the combined activity of these endogenous proteases was optimal at pH 4–5 and 50–60°C. The oleosins were the most easily hydrolyzed by these proteases, followed by 11S and 7S globulins, and the 2S albumins had strong resistance to these proteases. By incubation at pH 5 and 60°C for 2 h, approximately 97% of total lipids in isolated sesame OB (78% of total lipids in sesame seeds) could be recovered as oil by centrifugation, whereas no oil could be obtained when the incubation time was 0 h. These results indicated that the endogenous protease‐induced degradation of oleosins was the key point for the efficient demulsification of isolated sesame OB.
The status of the anomalepidid snake Liotyphlops albirostris and the revalidation of three taxa based on morphology and ecological niche models
Authors: Linares‐Vargas Camilo A. , Bolívar‐García Wilmar , Herrera‐Martínez Alexandra , Osorio‐Domínguez Daniel , Ospina Oscar E. , Thomas Richard , Daza Juan D. 
Published: August 2021

AbstractLiotyphlops is a genus of blindsnakes distributed in Central and South America. We reviewed specimens of Liotyphlops albirostris along its current distribution range and, based on morphological data and ecological niche modeling analyses, we restrict the geographical range of L. albirostris and validate three previously described species. In this revision, we describe the morphological variation in the populations from Panamá, Colombia, Ecuador, and Venezuela, and propose a new taxonomic arrangement. We revalidate three previous synonyms of L. albirostris to full species status, while dividing the populations from Colombia in two subspecies―one attributed to a previously recognized species from the Caribbean region, and a new one from the Andean region. The new species differs from L. albirostris from Panamá in cephalic scale arrangements that effectively reduces the previously reported variability of these scales in L. albirostris. We also explore some osteological differences that are congruent with the variation observed. We hope that the recognition of these new species better represents the diversity within Liotyphlops, helping to bring these new species out of their cryptic status so that they will be considered in future conservation efforts.
Singlet oxygen‐responsive photorelease of tyramine
Authors: Jeong Dong Yeun , Yi Seung Yeon , You Youngmin 
Published: August 2021

AbstractA system capable of photoreleasing tyramine has been developed. The photodonor system consists of an isoindole cage of tyramine and a biscyclometalated Ir(III) complex singlet oxygen (1O2) photosensitizer. Photoirradiation at a wavelength of 365 nm produces tyramine, as evidenced by mass spectrometry and 1H NMR spectroscopy. The photorelease proceeds through two steps involving the formation of a Diels–Alder‐type [2 + 4] cycloadduct of 1O2, followed by the slow and spontaneous decomposition of the adduct into tyramine and 2‐benzoylbenzophenon.
Target‐Dependent Protection of DNA Aptamers against Nucleolytic Digestion Enables Signal‐On Biosensing with Toehold‐Mediated Rolling Circle Amplification
Authors: Bialy Roger M. , Li Yingfu , Brennan John D. 
Published: August 2021

AbstractWe report a generalizable strategy for biosensing that takes advantage of the resistance of DNA aptamers against nuclease digestion when bound with their targets, coupled with toehold mediated strand displacement (TMSD) and rolling circle amplification (RCA). A DNA aptamer containing a toehold extension at its 5′‐end protects it from 3′‐exonuclease digestion by phi29 DNA polymerase (phi29 DP) in a concentration‐dependent manner. The protected aptamer can participate in RCA in the presence of a circular template that is designed to free the aptamer from its target via TMSD. The absence of the target leads to aptamer digestion, and thus no RCA product is produced, resulting in a turn‐on sensor. Using two different DNA aptamers, we demonstrate rapid and quantitative real‐time fluorescence detection of two human proteins: platelet‐derived growth factor (PDGF) and thrombin. Sensitive detection of PDGF was also achieved in human serum and human plasma, demonstrating the selectivity of the assay.
A Dose‐Confirmation Phase 1 Study to Evaluate the Safety and Pharmacology of Glucarpidase in Healthy Volunteers
Authors: Fukaya Yutaka , Kimura Toshimi , Yoshimura Kenichi , Umemura Kazuo , Kawamoto Hiroshi 
Published: August 2021

AbstractGlucarpidase rapidly decomposes methotrexate. A phase 1 study of glucarpidase in an open‐label, randomized parallel group was conducted to evaluate the safety, pharmacokinetics, and other pharmacologic effects in Japanese healthy volunteers without methotrexate treatment. A dose of 50 U/kg (n = 8) or 20 U/kg (n = 8) of glucarpidase was administered as an intravenous injection, with 1 repeated dose at 48 hours after the first dose. No dose‐limiting toxicities, no significant clinical examination findings, and no clinically relevant differences between dose levels were observed. The pharmacokinetic parameters at a first dose of 20 or 50 U/kg were similar to those at a second dose and were as follows: half‐life, 7.45 and 7.25 hours; area under the plasma concentration–time curve from time 0 to infinity, 8.25 and 19.05 μg·h/mL; total clearance, 4.85 and 5.47 mL/min; and volume of distribution during the elimination phase, 3.12 and 3.41 L, respectively. The area under the plasma concentration–time curve increased in a generally linear dose‐proportional manner. An ethnicity specificity in the pharmacokinetic profile was not observed in Japanese volunteers. The serum folate concentration decreased after glucarpidase administration in all the volunteers. The production of anti‐glucarpidase antibody was observed in many cases in both cohorts. Although the long‐term effect of anti‐glucarpidase antibody will need to be investigated in the future, the effects produced by the anti‐glucarpidase antibody were not influenced by the pharmacokinetics of glucarpidase within 96 hours after the first dose. The observed safety and tolerability, pharmacokinetics, and pharmacodynamics support the continued evaluation of glucarpidase in the patients with lethal methotrexate toxicities.
A codesign framework for online data analysis and reduction
Authors: Mehta Kshitij , Allen Bryce , Wolf Matthew , Logan Jeremy , Suchyta Eric , Singhal Swati , Choi Jong Y. , Takahashi Keichi , Huck Kevin , Yakushin Igor , Sussman Alan , Munson Todd , Foster Ian , Klasky Scott 
Published: August 2021

AbstractScience applications preparing for the exascale era are increasingly exploring in situ computations comprising of simulation‐analysis‐reduction pipelines coupled in‐memory. Efficient composition and execution of such complex pipelines for a target platform is a codesign process that evaluates the impact and tradeoffs of various application‐ and system‐specific parameters. In this article, we describe a toolset for automating performance studies of composed HPC applications that perform online data reduction and analysis. We describe Cheetah, a new framework for composing parametric studies on coupled applications, and Savanna, a runtime engine for orchestrating and executing campaigns of codesign experiments. This toolset facilitates understanding the impact of various factors such as process placement, synchronicity of algorithms, and storage versus compute requirements for online analysis of large data. Ultimately, we aim to create a catalog of performance results that can help scientists understand tradeoffs when designing next‐generation simulations that make use of online processing techniques. We illustrate the design of Cheetah and Savanna, and present application examples that use this framework to conduct codesign studies on small clusters as well as leadership class supercomputers.
Regulation of Circularly Polarized Luminescence in Multicomponent Supramolecular Coassemblies
Authors: Zhao Jianjian , Xing Pengyao 
Published: August 2021

AbstractCircularly polarized luminescence (CPL) active materials have received increasing attention due to their promising applications in fields such as photoelectric devices, spintronic devices and information storage systems. In developing CPL‐active materials, the key issue is to amplify the dissymmetry g‐factor (glum) and flexibly regulate the handedness, luminescence color and other properties. Relying on non‐covalent forces, multicomponent assembly provides an effective solution for control over CPL features. This Minireview summarizes recent progress in the regulation and amplification of CPL‐active materials in multicomponent coassembled systems, where the role of solvents, metal ions, quantum dots, achiral luminophores and nematic liquid crystals as well as a series of photophysical approaches including Förster resonance energy transfer (FRET), charge transfer (CT), arene‐perfluoroarene (AP) interactions and photon upconversion between different components are discussed. Furthermore, future challenges and opportunities of CPL‐active materials in multicomponent assembly systems are also reviewed. This Minireview aims to provide inspiration for the rational design and manufacture of CPL‐active materials based on multicomponent assembly.