bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Body Mass Index With Risk of Early-Onset Colorectal Cancer: Systematic Review and Meta-Analysis
Authors: Li Hengjing , Boakye Daniel , Chen Xuechen , Hoffmeister Michael , Brenner Hermann 
Published: July 2021

INTRODUCTION:
Incidence of colorectal cancer (CRC) in young adults has been increasing in recent decades in many countries for still widely unclear reasons. Suspected candidates include increasing prevalence of overweight and obesity, but specific evidence on their role for early-onset CRC (EOCRC) is sparse. We conducted a systematic review and meta-analysis to summarize available evidence on the association of body mass index (BMI) with EOCRC.

METHODS:
We systematically searched PubMed, EMBASE, and Web of Science up to February 2021 for studies that evaluated the association of BMI (before diagnosis but not near diagnosis) with CRC risk and reported specific results for EOCRC. Results from studies with similar BMI groupings were summarized in meta-analyses using random-effects models.

RESULTS:
Twelve studies were eligible and included. Results of 6 studies were pooled in meta-analyses, which yielded a higher risk of EOCRC for overweight and obesity (BMI ≥25 kg/m2) compared with normal weight (odds ratio [OR] 1.42, 95% confidence interval [CI] 1.19–1.68). An increasing risk with increasing BMI was observed, with much higher risk for obesity (OR 1.88, 95% CI 1.40–2.54) than for overweight (OR 1.32, 95% CI 1.19–1.47).

DISCUSSION:
Obesity is a strong risk factor for EOCRC, and its increasing prevalence in younger generations is likely to substantially contribute to the increase in EOCRC. Efforts to limit the obesity epidemic in adolescents and younger adults may be crucial for reducing CRC incidence in future generations of adults.
Maternal Oxycodone Treatment Results in Neurobehavioral Disruptions in Mice Offspring
Authors: Martin Rachel E. , Green Madison T. , Kinkade Jessica A. , Schmidt Robert R. , Willemse Tess E. , Schenk A. Katrin , Mao Jiude , Rosenfeld Cheryl S. 
Published: July 2021

AbstractOpioid drugs are increasingly being prescribed to pregnant women. Such compounds can also bind and activate opioid receptors in the fetal brain, which could lead to long-term brain and behavioral disruptions. We hypothesized that maternal treatment with oxycodone (OXY), the primary opioid at the center of the current crisis, leads to later neurobehavioral disorders and gene expression changes in the hypothalamus and hippocampus of resulting offspring. Female mice were treated daily with 5 mg OXY/kg or saline solution (control; CTL) for two weeks before breeding and then throughout gestation. Male and female offspring from both groups were tested with a battery of behavioral and metabolic tests to measure cognition, exploratory-like, anxiety-like, voluntary physical activity, and socio-communication behaviors. qPCR analyses were performed for candidate gene expression patterns in the hypothalamus and hippocampus of OXY and CTL derived offspring. Developmental exposure to OXY caused socio-communication changes that persisted from weaning through adulthood. Such offspring also showed cognitive impairments, reduced voluntary physical activity, and weighed more than CTL counterparts. In the hippocampus, prenatal exposure to OXY caused sex-dependent differences in expression of genes encoding opioid receptors and those involved in serotonin signaling. OXY exposure induced changes in neuropeptide hormone expression and the epigenetic modulator,Dnmt3a, in the hypothalamus, which could result in epigenetic changes in this brain region. The findings suggest cause for concern that consumption of OXY by pregnant mothers may result in permanent neurobehavioral changes in their offspring. Further work is needed to determine the potential underpinning epigenetic mechanisms.
Heterogeneous Expression of Nuclear Encoded Mitochondrial Genes Distinguishes Inhibitory and Excitatory Neurons
Authors: Wynne Meghan E. , Lane Alicia R. , Singleton Kaela S. , Zlatic Stephanie A. , Gokhale Avanti , Werner Erica , Duong Duc , Kwong Jennifer Q. , Crocker Amanda J. , Faundez Victor 
Published: July 2021

AbstractMitochondrial composition varies by organ and their constituent cell types. This mitochondrial diversity likely determines variations in mitochondrial function. However, the heterogeneity of mitochondria in the brain remains underexplored despite the large diversity of cell types in neuronal tissue. Here, we used molecular systems biology tools to address whether mitochondrial composition varies by brain region and neuronal cell type in mice. We reasoned that proteomics and transcriptomics of microdissected brain regions combined with analysis of single-cell mRNA sequencing (scRNAseq) could reveal the extent of mitochondrial compositional diversity. We selected nuclear encoded gene products forming complexes of fixed stoichiometry, such as the respiratory chain complexes and the mitochondrial ribosome, as well as molecules likely to perform their function as monomers, such as the family of SLC25 transporters. We found that the proteome encompassing these nuclear-encoded mitochondrial genes and obtained from microdissected brain tissue segregated the hippocampus, striatum, and cortex from each other. Nuclear-encoded mitochondrial transcripts could only segregate cell types and brain regions when the analysis was performed at the single-cell level. In fact, single-cell mitochondrial transcriptomes were able to distinguish glutamatergic and distinct types of GABAergic neurons from one another. Within these cell categories, unique SLC25A transporters were able to identify distinct cell subpopulations. Our results demonstrate heterogeneous mitochondrial composition across brain regions and cell types. We postulate that mitochondrial heterogeneity influences regional and cell type-specific mechanisms in health and disease.
Factors Related to Utilization of Maternal Child Health Handbook Data by Midwives
Authors: Dharmawan Yudhy , Pradana Atha Rifqia , Winarni Sri 
Published: July 2021

Midwives are one of the health workers utilizing the MCH (Maternal Child Health) handbook which records the data used to prevent infant, under-five, and maternal mortality. This study aimed to investigate factors related to utilization of the MCH handbook data, namely individual, organizational, and operational techniques. Quantitative approach was used in a cross-sectional survey with a structured questionnaire. Thirty-one midwives were selected as the sample from Active Alert Village in Temanggung district with rural and urban area representative consideration. Besides, descriptive data were tabulated, and inferential analysis was conducted by Pearson product-moment correlation. Result showed the rate of MCH Handbook data utilization was 78.54%. Also, data requirement perception, data filling skill, motivation, attitudes of midwives and facilities availablity (p < 0.05) are significantly related. The MCH handbook data utilization was determined by the individual factor, but with no significant relationship to operational and organizational factors except facilities availability. Therefore, efforts are required to improve data utilization by increasing data requirement perception, data filling skills, motivation and midwives attitudes.
Online Affirmation and Peer Support are Effective for Reducing Medical Personnel Stress in Dealing with Covid-19 Patients
Authors: Saleha Nurmukaromatis , Delfina Rina , Nurlaili Nurlaili , Ardiansyah Fourni , Nafratilova Mercy 
Published: July 2021

The Covid-19 outbreak has psychological impacts on frontline medical personnel at risk of infection. Therefore, this study aimed to evaluate the effect of online affirmations and peer support on medical personnel stress level in dealing with Covid-19 patients, as well as social support and spiritual intelligence's influence. It was a quasi-experiment with pre- and post-test administered to 25 and 30 medical personnel as the intervention and control groups, respectively. The intervention was carried out on WhatsApp group for 4 weeks. The stress level pair T-test results showed p = 0.000 in the intervention group and p = 0.238 in the control, while the independent T-test results showed p = 0.009. Social support did not affect medical personnel’s stress (p=0.978), but the effect of spiritual intelligence was significant (p=0.000). According to the results of multiple regression test conducted using the Enter method, the coefficient value (R2) = 0.584. This intervention was effective in helping medical personnel to manage stress. Hence, hospital managers need to carry out stress management training to maintain medical personnel’s mental health.
Type D Personality and Essential Hypertension in Semarang City, Indonesia: A Primary Healthcare Center-based Case-Control Study
Authors: Fauzi Lukman , Rahayu Sri Ratna , Anggorowati Lindra 
Published: July 2021

Type D personality is defined as the interaction between negative affectivity (NA) and social inhibition (SI). Hypertension has the highest cases in primary healthcare center (PHC) in Semarang City compared to other non-communicable diseases. This study aims to determine type D personality role on essential hypertension. It was a case-control study conducted at the PHC in Semarang City from January 2020 to March 2021 with 139 cases and 139 controls among 18-60 years old patients. Sample collection was performed by stratified random sampling. The instruments used were the DS-14 scale, structured questionnaire IPAQ-SF, food frequency questionnaire, and the Holmes and Rahe Stress Scale, while data were analyzed using logistic regression. The prevalence of type D personality in the case group (64%; 95%CI: 55.9%-72.1%) was higher than in the control (36.7%; 95%CI: 28.7%-44.7%). Type D personality was discovered to be significantly associated with essential hypertension (OR: 3.07; 95%CI: 1.83-5.16). After other covariates adjustment, the association was still statistically significant (AdjOR: 2.41; 95%CI: 1.32-4.41).
Pertenecer, mucho más que habitar un espacio. Tensiones emergentes tras reubicación en viviendas formales de residentes de la consolidación habitacional Juan Bobo en Medellín, Antioquia (2017-2019)
Authors: Herran Coppelia 
Published: July 2021

Esta investigación está relacionada con el modelo de intervención territorial empleado por las administraciones de Medellín 2004-2011, por medio de la cual se buscó conectar los asentamientos informales a la dinámica formal de la ciudad de Medellín. A través de la construcción de grandes obras arquitectónicas en los sectores con los índices más bajos de calidad de vida y de desarrollo humano ubicados en las zonas norte, centro oriental y centro occidental, se dirigió la mirada a la Consolidación Habitacional de la Quebrada Juan Bobo como uno de los proyectos más emblemáticos a nivel arquitectónico de la ciudad, por generar vivienda nueva en cuenca de quebrada beneficiando a 1.240 personas que fueron reubicadas dentro del mismo barrio, incluso sobre el mismo sitio donde estaban antes construidas sus antiguas viviendas.
The assessment of the pituitary volume in normal prepubertal children with three-dimensional MRI
Authors: OKUR AKŞAN İlknur , SARI Ahmet 
Published: July 2021

Purpose: The aim of the present study is to measure the pituitary volume of the children who are under 12 years of age with normal pituitary function and find the reference interval of the normal pituitary volume in the prepubertal period
Materials and Methods: A total 240 healthy children (120 boys- 120 girls) under the age of 12 yr who came our clinic for cranial MRI imaging for various indications within 2 years, were examined. The volume of pituitary gland was measured using a thin-section three dimensional magnetic resonance imaging (MRI) sequences of magnetization-prepared rapid gradient echo imaging with a 1-mm thick reconstructed sagittal images. We also examined the midline sagittal T1-weighted images for the measurement of the pituitary height
Results: The pituitary gland volume and height demonstrated increasing trend with the age for both genders in the prepubertal period. Although the pituitary volume in the neonatal period is higher in boys than in girls, it became opposite with the age of 6 yr. The height of the pituitary gland increases gradually-slowly with age; while it was higher in boys in the neonatal period, it was higher in girls at the age of 4 years. The lowest, highest and average values of the volume and height values of pituitary gland were found for each age and gender. The reference values of the pituitary volume values containing 5-10-25-50-75-90-95th percentiles were formed for each age and gender.
Conclusion: 3D MRI can be used for direct measurement of pituitary volume in prepubertal children. Measuring of pituitary volume using this 3D technique may permit a more precise assessment of the developing pituitary gland in children.
Pengaruh Suhu Awal Media Pendingin Terhadap Kekerasan dan Kekuatan Impact pada Baja Karbon Medium yang Diperlakukan Quenching
Authors: Rendisetyo Rendisetyo 
Published: July 2021

Abstract: The porpose of this study was find out the effect of intial temperatur colling medium on harness and toughness of medium steel carbon with quenching prosess. The steel will be used is S50C and the cooling medium with value viscosity of 20-40. The research methods used is kuantitatif with pre-eksperiment design and one-group spesimen control and spesimen eksperimen category. The variation initial temperature colling medium used is 300C, 350C, 450C dan 550C. The results of this study indicate there is an increase in the value of hardness in line with an increase in oil temperature. At a temperature of 300C has a hardness value of 204.39 HVN and a toughness of 0.0618 Joules / mm, at a temperature of 350C a hardness value of 255.14 HVN and a toughness of 0.0478 joules / mm, 450C has a hardness value of 271.03 HVN and a toughness of 0.048 Joules / mm. And at 550C the value of hardness is 234.11 HVN and the toughness is 0.0525 Joules / mm. Keywords: temperature of oil, hardness, toughness, Steel S50C, Quenching.
Pelaksanaan Teaching Factory pada Bidang Pemesinan ditinjau Sarana Prasarana, Sumber Daya Manusia dan Dukungan Industri (Studi Kasus di SMK PGRI 3 Malang)
Authors: Wira Putra Ryan Eriandra 
Published: July 2021

Abstrak: Badan Pusat Statistik (BPS) mencatat di tahun 2020 pengangguran terbanyak berasal dari SMK sebesar 8,49%. Dalam mengantisipasi hal tersebut, sekolah menyelenggarakan model pembelajaran Teaching Factory (Tefa). Hasil penelitian di SMK PGRI 3 Malang menunjukan dari pemenuhan sarana prasarana pada pelaksanaan Tefa berpatokan pada pengerjaan job order yang diberikan industri. Pada sumber daya manusia, guru sudah memiliki sertifikat kompetensi dan siswa pelaksana Tefa dipilih melalui rekomendasi para guru. Kemudian untuk dukungan industri hanya berupa job order dan training guru. Kata kunci: Teaching Factory, Sarana, Instruktur, Industri
The influence of gingival biotypes on periodontal health: A cross-sectional study in a tertiary care center
Authors: Kurien J Tony , Narayan Vivek , RM Baiju , P Anju , G Thomas Sneha 
Published: July 2021

Dimensional characteristic of gingiva is a predisposing factor for initiation and course of periodontal diseases and conditions. Knowledge about variations of gingival biotype among subjects is a prognostic determinant in Periodontics.The purpose of the study was to determine the prevalence of gingival biotypes and to evaluate its influence on various periodontal health parameters.Among the patients who reported to the out-patient section, a cross-sectional study was done on those who satisfied the inclusion criteria.Gingival thickness was measured on six anterior teeth of maxillary and mandibular arch using no.15 endodontic spreader and digital caliper by a single examiner on 112 subjects. Another examiner recorded the clinical parameters pertaining to periodontal health. Subjects with gingival thickness 1.5mm were categorized to thin and those with 2mm into thick gingival biotype.Difference in mean values of quantitative variables was tested by Mann Whitney U test. Bivariate correlation was assessed by Pearson correlation. Multiple linear regression models were developed for modified gingival index and interproximal attachment loss.Prevalence of thin and thick gingival biotype was 48.21% and 39.28% respectively. Mean gingival thickness observed was 1.49±0.59mm. Mean score of all clinical parameters were significantly higher in thin gingival biotype. Gingival biotype had a negative correlation with modified gingival index and interproximal attachment scores.Thicker gingival biotype can be considered to have a protective effect against the development of periodontal pathology.
<b>Pacientes portadores de necessidades especiais</b>: abordagem odontológica e anestesia geral
Authors: Andrade Ana Paula Paiva de , Eleutéio Adriana Silveira de Lima Eleutéio 
Published: July 2021

Os indivíduos portadores de necessidades especiais são mencionados na história há muitos séculos. Atualmente, no Brasil, existem grupos isolados que prestam atendimento odontológico a estes pacientes. Baseado na literatura, o objetivo deste trabalho é possibilitar ao cirurgião-dentista um maior conhecimento sobre o atendimento odontológico
a pacientes com necessidades especiais - principalmente,
aos portadores de síndrome de Down, paralisia cerebral e deficiências audiovisuais - e a necessidade de anestesia geral. Como conclusão, foi possível constatar que, antes de iniciar o atendimento odontológico a essa população, é essencial ter uma visão ampla e completa do paciente especial, reconhecer a etiologia das deficiências e proporcionar, além de níveis elevados de saúde bucal, dignidade e melhor qualidade de vida.

DOI: 10.18363/rbo.v72i1/2.616
IMPLEMENTASI PENDEKATAN SAINTIFIK DALAM MEMBENTUK KARAKTER SISWA SEKOLAH DASAR DI MARTAPURA KALIMANTAN SELATAN
Authors: Rusdiyana Rusdiyana 
Published: July 2021

Penelitian ini bertujuan untuk mengetahui bagaimana implementasi pendekatan saintifik dalam membentuk karakter siswa sekolah Dasar di Martapura Kalimantan Selatan.Jenis penelitian ini adalah penelitian kuantitatif dengan metode survey. Desain Penelitian adalah deskriptif yaitu deskripsi tentang implementasi pendekatan saintifik dalam membentuk karakter siswa sekolah Dasar di Martapura Kalimantan Selatan. Populasi penelitian adalah semua guru Sekolah Dasar kota Martapura.Sampel penelitian 24 orang guru negeri di 4 Sekolah Dasar yang sudah menerapkan kurikulum 2013 sebagai wakil seluruh guru SD Kota Martapura.Teknik pengumpulan data menggunakan angket dan observasi.Instrumen angket tentang implementasi pendekatan saintifik dalam membentuk karakter siswa sekolah Dasar. Observasi dengan cara visiting Class dilakukan sampling pada beberapa guru SD untuk memvalidasi dan memverifikasi hasil angket. Teknik analisis yang digunakan adalah analisis deskriptif.Hasil penelitian implementasi pendekatan saintifik dalam membentuk karakter siswa Sekolah Dasar di Martapura diperoleh rata-rata 82,53 dengan kategori baik. Hasil observasi pada 4 orang guru diperoleh skor rata-rata pendekatan saintifik sebesar 87,50 dengan kategori baikdan hasil observasi pada 4 kelas diperoleh skor rata-rata karakter siswa sebesar 82,64 dengan kategori baik.Kata kunci :pendekatan saintifik, membentuk karakter, siswa Sekolah Dasar
MENINGKATKAN HASIL BELAJAR SISWA PADA KONSEP SIFAT-SIFAT CAHAYA MELALUI MODEL KOOPERATIF TIPE GROUP INVESTIGATION KELAS VIII C SMPN 24 BANJARMASIN
Authors: Usdekwati Zuraida 
Published: July 2021

Permasalahan dalam pembelajaran IPA pada konsep sifat-sifat cahaya sulit dipahami oleh siswa.Hal ini disebabkan guru monoton hanya menggunakan metode ceramah, sehingga aktivitas siswa hanya mencatat dan mendengarkan. Akibatnya, berpengaruh pada hasil belajar siswa yang mencapai KKM 70 hanya 30% dengan nilai rata-rata 45,5. Oleh karena itu, perlu dilakukan perbaikan melalui model pembelajaran Group Investigation. Penelitian ini bertujuan untuk meningkatkan kinerja guru, aktivitas siswa, dan hasil belajar siswa pada konsep sifat-sifat cahaya melalui model pembelajaran Group Investigation karena model ini dapat melibatkan siswa secara aktif, dan menemukan konsep-konsep IPA secara kelompok.Metode penelitian yang digunakan adalah penelitian tindakan kelas dengan rancangan 2 siklus yang terdiri dari 2 pertemuan pada siklus I dengan sampel 35 orang siswa kelas VIII C Instrumen yang digunakan adalah lembar observasi kegiatan guru, lembar observasi kegiatan siswa, dan tes tertulis.Analisis data dilakukan dengan mereduksi data dan menyimpulkan hasil penelitian.Hasil penelitian menunjukkan bahwa hasil belajar siswa pada siklus I pertemuan 1 mencapai 50% dan pada pertemuan 2 meningkat menjadi 70%, dan pada siklus II pertemuan 1 meningkat menjadi 90%. Aktivitas siswa secara klasikal maupun kelompok dalam proses pembelajaran pada siklus I pertemuan 1 ada 25% siswa yang aktif, pertemuan 2 meningkat menjadi 75% siswa yang aktif, dan pada siklus II pertemuan 1 menjadi 50% siswa yang aktif dan 50% sangat aktif. Aktivitas guru dalam pengelolaan pembelajaran juga mengalami peningkatan dengan kriteria sangat baik.Kata Kunci :Hasil belajar IPA, sifat-sifat cahaya, model group investigation
БАГАТОФУНКЦІОНАЛЬНИЙ СТИМУЛЯТОР БІОЛОГІЧНО АКТИВНИХ ТОЧОК
Authors: Богомолов Микола Федорович , Орець Єлизавета Андріївна 
Published: July 2021

Поєднання трьох окремих методів пунктури , а саме: електричної, лазерної та ультразвукової та пристрою пошуку біологічно активних точок за електропровідністю шкіри допоможе пришвидшити встановлення лікарем більш точного клінічного і пунктурного діагнозу пацієнту неінвазивним способом. Реалізація лікувального ефекту здійснюється за рахунок пунктурного ефекту-точка акупунктури- канал (меридіан)- орган. Можливість комбінування різних методів впливу також може полегшити роботу лікаря та більш ефективніше діяти на БАТ не викликаючи звикання до однотипного подразнення.
СТРОМАЛЬНО-ВАСКУЛЯРНА ФРАКЦІЯ ЖИРОВОЇ ТКАНИНИ: ПЕРСПЕКТИВИ ДЛЯ РЕГЕНЕРАТИВНОЇ БІОІНЖЕНЕРІЇ
Authors: Лисичина Світлана , Мотроненко Валентина 
Published: July 2021

Реферат – Бурхливий розвиток пластичної естетичної хірургії сприяв збільшенню досліджень якостей жирової тканини, яка залишалась після операцій ліпосакції. Це допомогло детально описати її потенціал і з’ясовати, що в стромально-васкулярній фракції (СВФ) жирової тканини містяться стовбурові клітини, які можуть бути потенційним джерелом матеріалів для регенеративної медицини.
Наразі ведуться десятки досліджень, спрямованих на вивчення потенціалу СВФ, зокрема її застосування при проблемах шкіри, шрамах, остеоартрозі, тендинопатії, загоєнні ран, андрогенній алопеції, васкулопатії, мігрені та рубцюванні голосових складок. Та попри значну кількість досліджень і можливих перспектив, поки ще немає офіційно затверджених протоколів і дозволів використання цієї методики для лікування конкретних хвороб. Оскільки проведених експериментів ще недостатньо, а правове регулювання цієї сфери не сформовано.
У цій роботі аналізуються останні систематичні та стислі літературні огляди, що стосуються біологічних властивостей, клінічних застосувань та регуляторних вимог до СВФ з метою формування загального уявлення про поточний статус СВФ жирової тканини, як альтернативного джерела для регенеративної медицини.