bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model of educational personality profile for learning management and development of personal potential
Authors: Kushnir M. E. , Rabinovich P. D. , Zavedenskiy K. E. , Bazarova G. T. , Tsarkov I. S. 
Published: December 2021

The article describes the logic of the development of the model SKQIiSPEC (“Personality diamond”), including basis of its construction and approach to practical implementation.The relevance of the article is based on the problem of reveal and support of the development of educational agency, the formation of system competencies of self-determination, goal setting, productive action and reflection.The purpose of the research described in the article is to develop a model of the educational personality profile for managing educational activity and the development of personal potential, adequate for supporting educational agency.Novelty of the suggested approach is represented by developed structure of educational profile of a student SKQIiSPEC and its specially selected elements. The model is synthesized on the basis of the following key ideas: (1) model of personality competence iSPEC, (2) model of “education” via semiotic systems, (3) distinguishing of competences via types of solved tasks and (4) distinguishing of main activity type. The model integrates selected ideas with qualitative differences opposite to comparing evaluations. Therefore, “Personality dimond” provides sufficient depth and conciseness for monitoring of navigation of a student on its individual/collectively-individual educational track as well as for creation of possibility to be used in various systems for assessing educational results.Practical significance of model SKQIiSPEC is based on potential usage for mapping of educational ambitions and demands of personality, creation of educational strategies for collective-individual and individual tracks, organization of personal educational logistic. The usage of digital technologies enables automatisation of educational profile model for educational activities’ management.
NFATc1 and Tumor Associated Macrophages Affect Progression of Certain Subsets of Diffuse Large B Cell Lymphoma Non-GCB Subtypes
Authors: Murti Krisna , Muslina Muslina , Kartika Ika , Hidayat Rachmat , Amalia Ella 
Published: December 2021

Introduction: Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma among B cell lymphomas. The interaction of tumor cells with their microenvironment (tumor microenvironment, TME) leads to progressivity of malignancy. CD163 + macrophages known as components of TME. Nuclear factor of activated T cell (NFATc1) and MYC are important transcription factors in malignant transformation and progression. Therapeutic strategies were fast developed, nevertheless, efforts to decrease DLBCL morbidity and mortality are unsatisfied, therefore,new markers for prognosis and or therapeutic options of the patients are necessary. This study was aimed to investigate NFATc1 expression in DLBCL and its TME.
Methods: Thirty-two paraffin blocks were selected then immunostained for expression of NFATc1, MYC, and CD163. Clinopathologic data i.e. ages, gender, and proliferation index Ki-67 were obtained. Data was analyzed by statistics
Result: Positive expression of CD163 and NFATc1 was among 55% and 45% of cases respectively. All DLBCL cases in this study were non-GCB subtype and more patients were under 60 years (66%). Positive expression of CD163 was higher in males (69%) and in patients under 60 years (63%). Tissues positive for both NFATc1 and CD163 was observed higher among males and patients under 60 years.
Conclusion: NFATc1 may affect development and or progression of certain subsets of DLBCL non-GCB subtype.
PENINGKATAN PENGETAHUAN, SIKAP, DAN PERILAKU HIDUP BERSIH DAN SEHAT PADA IBU RUMAH TANGGA DIMASA PANDEMI COVID-19
Authors: Mustika Sari Sri , Saputra Nasution Ade 
Published: December 2021

PHBS dimasa pandemi sendiri merupakan salah satu bentuk upaya pencegahan penyebaran virus covid-19, banyak juga masyarakat yang meyakini bahwa fenomena Pandemi ini merupakan suatu konspirasi yang bertujuan untuk menguntungkan beberpa pihak sehigga banyak masyarakat yang acuh terhadap pentingnya PHBS selama pandemi. Kegiatan ini dilakukan dengan menggunakan metode kuantitatif dan mengumpulakn data melalui kuesioner dan observasi. Didalam kuesioner terdapat 30 pertanyaan dengan 3 variabel dimana diketahui bahwa pengetahuan ibu rumah tangga tentang PHBS selama masa pandemi covid masih sangat kurang (47%), kemudian bagaimana sikap atau tanggapan ibu rumah tangga tentang PHBS dan covid-19 dikategorikan cukup (60%), serta perilaku PHBS selama masa pandemi covid-19 dikategorikan kurang (53%). Kemudian pada tahap observasi dapat disimpulkan bahwa terdapat sedikit peningkatan pengetahuan, sikap dan perilaku yang berarti bahwa kegiatan sosialisasi ini kuarng efektif. Maka dari itu besar harapan kepada pemerintah untuk meningkatkan kualitas PHBS dan melaksanakan kegiatan sosialisasi tentang wabah covid-19 pada masyarakat.
IMUNISASI SAAT PANDEMI COVID-19 DI KAMPUNG SUDIMAMPIR DESA CIMANGGIS KEC.BOJONGGEDE KAB.BOGOR TAHUN 2020
Authors: Serliyanti Sindi , Asnifatima Andi 
Published: December 2021

Pandemi covid-19 yang saat ini terjadi di beberapa negara salah satunya adalah Indonesia, membuat masyarakat Indonesia harus terbiasa dengan semua perubahan mulai dari kehidupan sehari-hari, pekerjaan, peribadahan bahkan sampai dengan pelayanan kesehatan misalnya kegiatan posyandu. Kondisi ini juga dihadapi oleh warga Rt 02 Rw 03 Desa Cimanggis Kecamatan Bojonggede Kabupaten Bogor. Oleh karena itu diperlukan program yang dapat meningkatan pengetahuan masyarakat mengenai imunisasi saat pandemi covid-19 program ini bernama Edukasi online. Tujuan umum dari kegiatan pengabdian masyarakat ini adalah untuk meningkatan pengatahuan masyarakat mengenai pandemi covid-19. Sedangkan tujuan khusus yang ingin dicapai dalam kegiatan pengabdian ini adalah ibu tetap membawa anaknya untuk imunisasi, ibu mendapatkan informasi mengenai pentingnya imunisasi bagi kesehatan anak, dan ibu mengetahui cara membawa anak untuk imunisasi saat pandemi covid 19 dan tetap terjaga dari penularan virus covid 19. Metode yang digunakan dalam program ini adalah melalui daring atau online dengan memanfaatkan jajaring komunikasi whatsapp grup. Metode evaluasi dalam kegiatan ini dengan memberikan survey serta melakukan assesmen manual. Hasil yang dicapai menunjukan peningkatan pengetahuan masyarakat mengenai pandemi covid-19 dan pentingnya tetap melakukan imunisasi saat pandemi covid-19. Sehingga dapat disimpulkan kegiatan ini dapat menjadi salah satu cara untuk meningkatkan pengetahuan masyarakat.
Diazoxide Post-conditioning Activates the HIF-1/HRE Pathway to Induce Myocardial Protection in Hypoxic/Reoxygenated Cardiomyocytes
Authors: Chen Xi-Yuan , Wang Jia-Qi , Cheng Si-Jing , Wang Yan , Deng Meng-Yuan , Yu Tian , Wang Hai-Ying , Zhou Wen-Jing 
Published: December 2021

Background: Previous studies have shown that diazoxide can protect against myocardial ischemia-reperfusion injury (MIRI). The intranuclear hypoxia-inducible factor-1 (HIF-1)/hypoxia-response element (HRE) pathway has been shown to withstand cellular damage caused by MIRI. It remains unclear whether diazoxide post-conditioning is correlated with the HIF-1/HRE pathway in protective effect on cardiomyocytes.Methods: An isolated cardiomyocyte model of hypoxia-reoxygenation injury was established. Prior to reoxygenation, cardiomyocytes underwent post-conditioning treatment by diazoxide, and 5-hydroxydecanoate (5-HD), N-(2-mercaptopropionyl)-glycine (MPG), or dimethyloxallyl glycine (DMOG) followed by diazoxide. At the end of reoxygenation, ultrastructural morphology; mitochondrial membrane potential; interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), reactive oxygen species (ROS), and HIF-1α levels; and downstream gene mRNA and protein levels were analyzed to elucidate the protective mechanism of diazoxide post-conditioning.Results: Diazoxide post-conditioning enabled activation of the HIF-1/HRE pathway to induce myocardial protection. When the mitoKATP channel was inhibited and ROS cleared, the diazoxide effect was eliminated. DMOG was able to reverse the effect of ROS absence to restore the diazoxide effect. MitoKATP and ROS in the early reoxygenation phase were key to activation of the HIF-1/HRE pathway.Conclusion: Diazoxide post-conditioning promotes opening of the mitoKATP channel to generate a moderate ROS level that activates the HIF-1/HRE pathway and subsequently induces myocardial protection.
Clinical and Echocardiographic Parameters Predicting 1- and 2-Year Mortality After Transcatheter Aortic Valve Implantation
Authors: Kjønås Didrik , Schirmer Henrik , Aakhus Svend , Eidet Jo , Malm Siri , Aaberge Lars , Busund Rolf , Rösner Assami 
Published: December 2021

Background: Transcatheter aortic valve implantation (TAVI) has become a standard treatment option for patients with symptomatic aortic stenosis. Elderly high-risk patients treated with TAVI have a high residual mortality due to preexisting comorbidities. Knowledge of factors predicting futility after TAVI is sparse and clinical tools to aid the preoperative evaluation are lacking. The aim of this study was to evaluate if echocardiographic measures, including speckle-tracking analysis, in addition to clinical parameters, could aid in the prediction of mortality beyond 30 days after TAVI.Methods: This prospective observational cohort study included 227 patients treated with TAVI at the University Hospital of North Norway, Tromsø and Oslo University Hospital, Rikshospitalet from February 2010 to June 2013. All the patients underwent preoperative echocardiographic evaluation with retrospective speckle-tracking analysis. Primary endpoints were 1- and 2-year mortality beyond 30 days after TAVI.Results: All-cause 1- and 2-year mortality beyond 30 days after TAVI was 12.1 and 19.5%, respectively. Predictors of 1-year mortality beyond 30 days were body mass index [hazard ratio (HR): 0.88, 95% CI: 0.80–0.98, p = 0.018], previous myocardial infarction (HR: 2.69, 95% CI: 1.14–6.32, p = 0.023), and systolic pulmonary artery pressure ≥ 60 mm Hg (HR: 5.93, 95% CI: 1.67–21.1, p = 0.006). Moderate-to-severe mitral regurgitation (HR: 2.93, 95% CI: 1.53–5.63, p = 0.001), estimated glomerular filtration rate (HR: 0.98, 95% CI: 0.96–0.99, p = 0.002), and chronic obstructive pulmonary disease (HR: 1.9, 95% CI: 1.01–3.58, p = 0.046) were predictors of 2-year mortality.Conclusion: Both the clinical and echocardiographic parameters should be considered when evaluating high-risk patients for TAVI, as both are predictive of 1-and 2-year mortality. Our results support the importance of individual risk assessment using a multidisciplinary, multimodal, and individual approach.
Electrocardiogram Characteristics and Prognostic Value in Light-Chain Amyloidosis: A Comparison With Cardiac Magnetic Resonance Imaging
Authors: Guo Xinli , Chen Zhian , Wan Ke , Song Rizhen , Yang Tingjie , Xu Yuanwei , Zhang Qing , Alexander Kevin Michael , Han Yuchi , Chen Yucheng 
Published: December 2021

Background: An electrocardiogram (ECG) is a simple and cheap non-invasive tool that shows various abnormalities and has prognostic value for patients with light-chain amyloidosis (AL). The present study aimed to explore the association between ECG characteristics and cardiac magnetic resonance (CMR)-detected amyloid burden and to investigate the prognostic value of ECG in AL amyloidosis.Methods: We prospectively enrolled 99 patients with AL amyloidosis (56 male patients; median age, 58 y). Detailed clinical information, 12-lead ECG, and CMR data were collected. All patients were followed up longitudinally, and the endpoint was all-cause mortality. ECG characteristics were analyzed and correlated with the degree of late gadolinium enhancement (LGE) and extracellular volume (ECV) by T1 mapping on CMR. The prognostic value of ECG characteristics was analyzed using Kaplan–Meier survival analysis and multivariate Cox regression.Results: During a median follow-up period of 33 months, 69 of the 99 patients died. Fragmented Q wave-R wave-S wave (QRS), pathological Q waves, the Sokolow index, QRS duration, and voltages were significantly associated with the extent of LGE, native T1, and ECV by CMR (p &lt; 0.05). Fragmented QRS and Sokolow index showed independent prognostic value in AL amyloidosis (p = 0.001; p = 0.026, respectively). Fragmented QRS remained independent after adjusting for clinical values (hazard ratio: 2.034; 95% confidence interval: 1.148–3.603; p = 0.015). However, no ECG characteristics were independent predictors for prognosis in AL amyloidosis when LGE and ECV were included in the multivariate analysis.Conclusion: ECG abnormalities showed significant association with CMR indicators of amyloid burden. Fragmented QRS has an independent prognostic value in AL amyloidosis and could be used as an alternative marker when CMR is not available.
Differential Presentations of Arterial Thromboembolic Events Between Venous Thromboembolism and Atrial Fibrillation Patients
Authors: Lin Yu-Sheng , Lin Ming-Shyan , Wu Victor Chien-Chia , Chen Yung-Lung , Chang Jung-Jung , Chu Pao-Hsien , Lip Gregory Y. H. , Chen Mien-Cheng 
Published: December 2021

Objective: Atrial fibrillation (AF) and venous thromboembolism (VTE) share several risk factors related to arterial thromboembolism. No study has reported the differential contribution to arterial thromboembolic events and mortality between these two conditions in the same population. We therefore assessed the differential arterial thromboembolic events between AF and VTE.Methods: We included AF and VTE national cohorts derived from Taiwan National Health Insurance Research Database between 2001 and 2013. The eligible population was 314,861 patients in the AF cohort and 41,102 patients in the VTE cohort. The primary outcome was arterial thromboembolic events, including ischemic stroke, extracranial arterial thromboembolism (ECATE) and myocardial infarction (MI). Secondary outcomes were all-cause mortality and cardiovascular death.Results: After a 1:1 propensity matching, 32,688 patients in either group were analyzed. The risk of arterial thromboembolic events was lower in the VTE cohort than that in the AF cohort (subdistribution hazard ratio [SHR], 0.60; 95% confidence interval [CI], 0.57–0.62). The risk of ischemic stroke (SHR, 0.44; 95% CI, 0.42–0.46) and MI (SHR, 0.80; 95% CI, 0.72–0.89) were lower in the VTE cohort, while the risk of ECATE (SHR, 1.23; 95% CI, 1.14–1.33; particularly lower extremities) was higher in the VTE cohort. All-cause mortality rate was higher in the VTE cohort (HR, 1.18; 95% CI, 1.15–1.21) while the risk of cardiovascular death was lower in the VTE cohort (HR, 0.96; 95% CI, 0.93–0.995).Conclusions: Patients with AF had higher risks of arterial thromboembolic events compared to patients with VTE, despite having risk factors in common. The VTE cohort had higher risks of all-cause mortality and ECATE, particularly lower extremity events, compared to AF patients. The differential manifestations of thromboembolism sequelae and mortality between AF and VTE patients merit further investigation.
Lipocalin-2 Variants and Their Relationship With Cardio-Renal Risk Factors
Authors: Li Dahui , Li Haoyun , Bauer Carlie , Hu Yue , Lewis Joshua R. , Xu Aimin , Levinger Itamar , Wang Yu 
Published: December 2021

ObjectivesTo investigate the serum, plasma and urine levels of lipocalin-2 (LCN2) variants in healthy humans and their associations with risk factors for cardiometabolic (CMD) and chronic kidney (CKD) diseases.MethodsFifty-nine males and 41 females participated in the study. Blood and urine were collected following an overnight fasting. LCN2 variants were analyzed using validated in-house ELISA kits. Heart rate, blood pressure, lipids profile, glucose, adiponectin, high-sensitivity C-reactive protein (hsCRP), creatinine, cystatin C, and biomarkers for kidney function were assessed.ResultsThe levels of hLcn2, C87A and R81E in serum and urine, but not plasma, were significantly higher in men than women. Increased levels of LCN2 variants, as well as their relative ratios, in serum and plasma were positively associated with body mass index, blood pressure, triglyceride and hsCRP (P&lt;0.05). No significant correlations were found between these measures and hLcn2, C87A or R81E in urine. However, LCN2 variants in urine, but not plasma or serum, were correlated with biomarkers of kidney function (P&lt;0.05).ConclusionsBoth the serum and plasma levels of LCN2 variants, as well as their ratios are associated with increased cardiometabolic risk, whereas those in urine are correlated with renal dysfunction. LCN2 variants represent promising biomarkers for CMD and CKD.
Interactions Between Dynamic Softening and Strengthening Mechanisms During Hot Forging of a High-Strength Steel
Authors: Khan Makarim , Shahriari Davood , Jahazi Mohammad , Morin Jean-Benoit 
Published: December 2021

Open-die forging is a critical step in the manufacture of large numbers of components used in the transportation and energy industries. Dynamic recrystallization, dynamic transformation, and dynamic precipitation take place during the hot deformation process and significantly affect microstructure conditioning, which ultimately influences the service properties of the component. In the present work, using a Gleeble 3800 thermomechanical simulator, the open-die forging of a large-size ingot made of a modified AISI 6140 medium carbon high-strength steel is investigated. Deformation temperatures ranging from 950°C to 1,250°C and strain rates ranging from 0.01 to 1 s−1, representative of the actual process, are considered in the analysis. The generated true stress–true strain curves are used as a basis for the development of a constitutive model predicting the occurrence of softening and strengthening phenomena as a function of thermomechanical conditions. The corresponding activation energy is determined to be about 374 kJ mol−1 and is compared against the values reported in the literature for other high-strength steels. Dynamic recrystallization kinetics is studied using the t50 model, and the influence of temperature and strain rate is quantified and discussed. The interaction between dynamic precipitation and dynamic recrystallization is discussed, and the deformation conditions under which such interactions occur are determined. The thermomechanical results are validated by microstructure examination, including laser confocal microscopy, field emission scanning electron microscopy, transmission electron microscopy, and energy-dispersive spectroscopy. The present study focuses on reproducing the deformation cycle applied during the open-die forging process of a vanadium-containing high-strength steel used in the industry with special attention to the interaction between dynamic recrystallization and precipitation processes.
High Expression of BCL11A Predicts Poor Prognosis for Childhood MLL-r ALL
Authors: Wang Lu-Lu , Yan Dehong , Tang Xue , Zhang Mengqi , Liu Shilin , Wang Ying , Zhang Min , Zhou Guichi , Li Tonghui , Jiang Feifei , Chen Xiaowen , Wen Feiqiu , Liu Sixi , Mai Huirong 
Published: December 2021

BackgroundDespite much improvement in the treatment for acute lymphoblastic leukemia (ALL), childhood ALLs with MLL-rearrangement (MLL-r) still have inferior dismal prognosis. Thus, defining mechanisms underlying MLL-r ALL maintenance is critical for developing effective therapy.MethodsGSE13159 and GSE28497 were selected via the Oncomine website. Differentially expressed genes (DEGs) between MLL-r ALLs and normal samples were identified by R software. Next, functional enrichment analysis of these DEGs were carried out by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA), and Search Tool for the Retrieval of Interacting Genes/Proteins (STRING). Then, the key hub genes and modules were identified by Weighted Gene Co-expression Network Analysis (WGCNA). Therapeutically Applicable Research to Generate Effective Treatments (TARGET) ALL (Phase I) of UCSC Xena analysis, qPCR, and Kaplan-Meier analysis were conducted for validating the expression of key hub genes from bone marrow cells of childhood ALL patients or ALL cell lines.ResultsA total of 1,045 DEGs were identified from GSE13159 and GSE28497. Through GO, KEGG, GSEA, and STRING analysis, we demonstrated that MLL-r ALLs were upregulating “nucleosome assembly” and “B cell receptor signal pathway” genes or proteins. WGCNA analysis found 18 gene modules using hierarchical clustering between MLL-r ALLs and normal. The Venn diagram was used to filter the 98 hub genes found in the key module with the 1,045 DEGs. We identified 18 hub genes from this process, 9 of which were found to be correlated with MLL-r status, using the UCSC Xena analysis. By using qPCR, we validated these 9 hub key genes to be upregulated in the MLL-r ALLs (RS4;11 and SEM) compared to the non-MLL-r ALL (RCH-ACV) cell lines. Three of these genes, BCL11A, GLT8D1 and NCBP2, were shown to be increased in MLL-r ALL patient bone marrows compared to the non-MLL-r ALL patient. Finally, Kaplan–Meier analysis indicated that childhood ALL patients with high BCL11A expression had significantly poor overall survival.ConclusionThese findings suggest that upregulated BCL11A gene expression in childhood ALLs may lead to MLL-r ALL development and BCL11A represents a new potential therapeutic target for childhood MLL-r ALL.
Ursodeoxycholic Acid Treatment Restores Gut Microbiota and Alleviates Liver Inflammation in Non-Alcoholic Steatohepatitic Mouse Model
Authors: Li Hu , Wang Qingling , Chen Peizhan , Zhou Chenghua , Zhang Xinxin , Chen Li 
Published: December 2021

Gut microbiota dysbiosis plays an important role in the progression of non-alcoholic fatty liver disease (NAFLD), and no approved drugs are available for NAFLD treatment. In this study, we aimed to explore the dynamic changes of gut microbiota at the different stages of NAFLD and determine whether ursodeoxycholic acid (UDCA) could improve liver histopathological features of non-alcoholic steatohepatitis (NASH) mice induced by a high-fat high-cholesterol (HFHC) diet and its impact on gut microbiota. 6-week-old male C57BL/6 mice were fed with a HFHC or normal diet for 12, 18, and 24 weeks, respectively, to simulate the different stages of NAFLD. 16s ribosomal RNA genes from mice fecal samples at the different time points were sequenced to evaluate the dynamic changes of the gut microbiota. Then, C57BL/6 mice were fed with a HFHC diet for 24 weeks to establish the NASH model. Different doses of UDCA were administered intragastrically for additional 4 weeks. Normal diet–fed mice were taken as control. Serum samples, liver, and intestine tissues were harvested for biochemical tests and histopathological examinations. 16s ribosomal RNA genes from mice fecal samples were sequenced to assess the structural changes of gut microbiota. HFHC diet–fed mice developed simple steatosis, steatohepatitis, and fibrosis at 12, 18, and 24 weeks, respectively. The profile of gut microbiota dynamically changed with the different stages of NAFLD. NASH mice had significantly higher abundance of Fecalibaculum, Coriobacteriaceae_UCG-002, and Enterorhabdus, and lower abundance of norank_f_Muribaculaceae, Bacteroides, and Alistipes, which were partially restored by UDCA treatment. UDCA treatment significantly attenuated hepatic inflammation of NASH mice as indicated by the sum of ballooning and lobular inflammation of the NALFD activity score (3.2 ± 0.8 vs 1.8 ± 0.8, p = 0.029), and partially restored gut microbiota dysbiosis, and increased the expression of Claudin-1 and ZO-1 in the intestine, but did not activate the suppressed Farnesoid X receptor signal pathway. Conclusions: The gut microbiota dynamically changes with the different stages of NAFLD. UDCA treatment (120 mg/kg) could partially restore gut microbiota, repair gut barrier integrity, and attenuate hepatic inflammation in the NASH mouse model.