bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric meningioma with rhabdoid features developed at the site of skull fracture: illustrative case
Authors: Takata Sho , Tamase Akira , Hayashi Yasuhiko , Tachibana Osamu , Sato Katsuaki , Iizuka Hideaki 
Published: October 2021

BACKGROUND
Pediatric meningiomas are rare, and only a few cases attributed to trauma and characterized by development at the site of bone fracture have been reported. Both pediatric and traumatic meningiomas have aggressive characteristics.

OBSERVATIONS
An 11-year-old boy who sustained a head injury resulting from a left frontal skull fracture 8 years previously experienced a convulsive attack. Imaging revealed a meningioma in the left frontal convexity. Total removal of the tumor with a hyperostotic section was successfully achieved. Intraoperative investigation showed tumor invasion into the adjacent frontal cortex. Histologically, the surgical specimen revealed a transitional meningioma with brain invasion and a small cluster of rhabdoid cells. This led to a final pathological diagnosis of an atypical meningioma with rhabdoid features. The postoperative course was uneventful, and no recurrence of the tumor was found after 2 years without adjuvant therapy.

LESSONS
This is the first report of a pediatric meningioma with rhabdoid features occurring at the site of a skull fracture. Meningiomas that contain rhabdoid cells without malignant features are not considered to be as aggressive as rhabdoid meningiomas. However, the clinical course must be carefully observed for possible long-term tumor recurrence.
Symptomatic interdural cerebrospinal fluid collections after surgery for idiopathic spinal cord herniation: illustrative case
Authors: Ohtake Yasufumi , Senoo Makoto , Fukuda Mamoru , Ishida Yuuki , Yoshihara Ryunosuke , Ishikawa Kohei , Fuchizaki Tomoki , Ishizuka Tomoaki , Okamura Naoyasu , Nakamura Hirohiko 
Published: October 2021

BACKGROUND
Idiopathic spinal cord herniation (ISCH) is very rare. Some reports have described postoperative ventral cerebrospinal fluid (CSF) collections in patients with ISCH; however, such collections are asymptomatic in most patients, and there is no consensus regarding whether they are part of the natural history or a complication.

OBSERVATIONS
A 30-year-old man with ISCH underwent direct closure of a duplicated dura mater. Eight months postoperatively, he developed reworsening of right lower limb paresis and new severe right arm pain and paresis. Three-dimensional magnetic resonance imaging revealed ventral CSF collections, which the authors judged as the responsible lesions. The authors initially considered these collections to be present in the epidural space, extradurally compressing the dural sac and resulting in myelopathy. An epidural blood patch failed; however, a CSF drainage test resulted in dramatic improvement. The authors therefore determined that the CSF collections were located in the interdural space, not the epidural space. A lumboperitoneal (LP) shunt was performed to reduce the CSF pressure. The patient’s symptoms improved immediately postoperatively. He had developed no recurrence of symptoms 6 months after surgery.

LESSONS
Ventral interdural CSF collections after ISCH surgery can cause reworsening of myelopathy and may be cured by a LP shunt to control CSF pressure.
Extended tulip cervical reduction screws to restore alignment in traumatic atlantoaxial dislocation after type 3 odontoid fracture: illustrative case
Authors: Dibble Christopher F. , Javeed Saad , Zhang Justin K. , Pennicooke Brenton , Ray Wilson Z. , Molina Camilo 
Published: October 2021

BACKGROUND
Traumatic atlantoaxial rotatory subluxation after type 3 odontoid fracture is an uncommon presentation that may require complex intraoperative reduction maneuvers and presents challenges to successful instrumentation and fusion.

OBSERVATIONS
The authors report a case of a 39-year-old female patient who sustained a type 3 odontoid fracture. She was neurologically intact and managed in a rigid collar. Four months later, she presented again after a second trauma with acute torticollis and type 2 atlantoaxial subluxation, again neurologically intact. Serial cervical traction was placed with minimal radiographic reduction. Ultimately, she underwent intraoperative reduction, instrumentation, and fusion. Freehand C1 lateral mass reduction screws were placed, then C2 translaminar screws, and finally lateral mass screws at C3 and C4. The C2–4 instrumentation was used as bilateral rod anchors to reduce the C1 lateral mass reduction screws engaged onto the subluxated atlantodental complex. As a final step, cortical allograft spacers were inserted at C1–2 under compression to facilitate long-term stability and fusion.

LESSONS
This is the first description of a technique using extended tulip cervical reduction screws to correct traction-irreducible atlantoaxial subluxation. This case is a demonstration of using intraoperative tools available for the spine surgeon managing complex cervical injuries requiring intraoperative reduction that is resistant to traction reduction.
Physical-chemical properties and microstructural characterization of traditional mexican chili (Capsicum annuum L.) powders
Authors: Perea-Flores María de J. , Fabela-Morón Miriam F. , Rayas-Amor Adolfo A. , Pérez-Ruíz Rigoberto V. , Ruíz-Hernández Rafael , Linares-Violante Betzabe , Ortega-Avilés Mayahuel , Barba-Bellettini Marcelo , Pérez-Alonso Cesar 
Published: October 2021

Objective: Evaluate the physical-chemical properties and characterize the microstructure of four varieties of traditional Mexican chili (Capsicum annuum L.) powders: “Arbol”, “Guajillo”, “Piquin” and “Mole ranchero” (Ancho chili).
Design/methodology/approach: Physical-chemical properties of chili powders were evaluated by means of moisture content, particle size, aerated and tapped bulk density, Carr index, Hausner ratio, angle of repose (flow properties), capsaicin, and carotenoids content. Microstructure of samples was characterized by Confocal Laser Scanning Microscopy and Scanning Electron Microscopy. ANOVA analysis and Tukey test were performed to evaluate the significant statistical difference between samples at 95% of confidence level.
Results: “Arbol”, “Guajillo”, “Piquin” and “Mole Ranchero” chili powders presented a cohesive behavior respect to its flow properties related to aerated and tapped bulk density, angle of repose, Carr Index, and Hausner ratio values under moisture content between 6.59-14.48 gH2O/100g d.s. “Arbol” and “Piquin” chili powders presented the higher capsaicin content, while “Guajillo” and “Mole ranchero” showed the higher carotenoids content. FTIR spectra confirmed the presence of secondary amide, phenolic groups, alkanes, and aliphatic chains that belong to capsaicin structure at specific absorption bands. Microstructure of chili powders presented particles with surface imperfections as cracks and dents, and smooth surface that influence physical-chemical and flowability properties.
Limitations on study/implications: Hight moisture content affect the physical-chemical properties, flowability and microstructure of traditional Mexican chili powders.
Findings/conclusions: Moisture content between 6.59 and 14.48 gH2O/100g d.s. influences the physical-chemical properties, flowability and microstructure of traditional Mexican chili powders. To improve physical-chemical properties and flowability behavior of chili powders is required that moisture content be lower than 6.59 H2O/100g d.s.
Model Rekomendasi Penerima Bantuan Sosial Berdasarkan Data Kesejahteraan Rakyat
Authors: Susanto Erliyan Redy , Puspaningrum Ajeng Savitri , Neneng Neneng 
Published: October 2021

Akibat adanya pandemi Covid-19 yang melanda dunia menyebabkan banyak negara mengalami berbagai krisis diantaranya ekonomi, sosial, agama, pendidikan dan sebagainya. Negara miskin, negara berkembang hingga negara maju berupaya untuk mengatasi berbagai dimensi yang dipengaruhi oleh krisis pandemi covid-19 ini. Bahkan negara Indonesia termasuk yang terdampak cukup parah akibat krisis ini. Masalah perekonomian dipandang sebagai masalah utama yang harus segera dicarikan solusi untuk mengatasi krisis ini. Bahkan pemerintah sudah membuat berbagai kebijakan strategis guna memulihkan perekonomian di Indonesia. Sebagai bagian dari tanggung jawab pemerintah dalam memulihkan perekonomian negara serta amanat undang-undang dasar negara 1945 untuk mensejakterakan rakyat maka pemerintah memberikan bantuan sosial dalam penanggulangan ekonomi. Akan tetapi banyak media yang memberitakan bahwa upaya bantuan sosial akibat dampak covid-19 yang dilakukan pemerintah banyak yang tidak tepat sasaran. Apabila hal ini benar-benar terjadi maka sasaran pemerintah untuk memperbaiki ekonomi tidak sesuai yang diharapkan. Masalah seperti ketidaktepatan sasaran penerimaan bantuan ini tentunya harus segera diatasi dan dicari solusinya agar tidak terulang lagi pada program-program bantuan di masa yang akan datang. Menjawab masalah ini maka perlu adanya suatu sistem untuk memberikan informasi yang akurat tentang kesejahteraan rakyat sehingga masalah tersebut segera diatasi. Oleh karena itu maka pemerintah perlu memiliki strategi yang tepat dalam menentukan kriteria untuk mengukur kelayakan dalam menerima bantuan sosial akibat dampak covid-19. Tujuan dari penelitian ini adalah membangun suatu model untuk memberikan rekomendasi penerima bantuan sosial akibat dampak covid-19 dengan studi kasus pada RT.01 LK III Sukajawa, Tanjung Karang Barat, Kota Bandar Lampung. Dalam artikel ini mepaparkan hasil penelitian tentang penggunaan metode Simple Additive Weighting untuk menentukan prioritas penerima bantuan sosial akibat dampak Covid-19 berdasarkan data kesejahteraan rakyat. Bahasa pemrograman berbasis web menggunakan bahasa PHP dan database MySQL digunakan untuk membangun prototype software rekomendasi penerima bantuan sosial akibat dampak covid-19. Sedangkan hasil penelitian adalah prototype dalam bentuk aplikasi komputer berbasis web yang dapat memberi rekomendasi masyarakat penerima bantuan sosial berdasarkan data kesejahteraan rakyat.
Sistem Informasi Monitoring dan Pemeliharaan Penggunaan SCADA (Supervisory Control and Data Acquisition)
Authors: Budiman Arief , Sunariyo Sunariyo , Jupriyadi Jupriyadi 
Published: October 2021

Supervisory Control and Data Acquisition (SCADA) merupakan fasilitas yang digunakan dalam pengawasan, pengontrolan dan pengumpulan data. Pengelolaan pemeliharaan penggunaan alat SCADA di PT PLN (Persero) Unit induk Pelaksana Pengatur Distribusi Lampung dirasa masih belum optimal. Dalam melaksanakan kegiatan pemeliharaan alat SCADA mulai dari pengisian perintah kerja, pengisian form pemeliharaan alat SCADA sampai dengan penyusunan laporan masih menggunakan buku dan google doc. Hal tersebut menyebabkan timbulnya beberapa permasalahan, seperti membutuhkan waktu yang lama untuk melakukan pencatatan dan pencarian data pemeliharaan. Oleh karena itu, penelitian ini dilakukan untuk merancang dan membangun sistem informasi manajemen monitoring pemeliharaan penggunaan alat SCADA berbasis web menggunakan framework codeigniter pada PT PLN (Persero) Unit Induk Pelaksana Pengatur Distribusi Lampung. Perancangan sistem informasi dilakukan menggunakan metode pengembangan sistem Web Engineering. Model tersebut dipilih karena sistem informasi ini berbasis web, sehingga pendekatan penelitian yang digunakan akan lebih tepat. Kerangka kerja yang digunakan web engineering menggunakan kerangka kerja umum rekayasa perangkat lunak yang aktivitasnya meliputi komunikasi, perencanaan, pemodelan, pembangunan dan deployment. Sistem akan dibangun menggunakan framework codeigniter dengan menggunakan bahasa pemrograman PHP dan MySQL sebagai basis datanya. Hasil dari pengujian sistem menunjukkan bahwa sistem informasi manajemen monitoring pemeliharaan penggunaan alat SCADA dapat berfungsi sesuai dengan yang diharapkan, dengan dukungan library yang lengkap pada framework codeigniter dapat mempercepat pembangunan sistem informasi manajemen monitoring dan pemeliharaan penggunaan alat SCADA. Implementasi sistem ini diperuntukan bagi empat aktor yang terlibat. Keempat aktor tersebut adalah admin, Petugas Pelaksana, Supervisi dan Manager Bagian. Pengujian sistem menunjukkan bahwa rancangan secara fungsional menghasilkan nilai sebesar 79,74% dengan kriteria baik, dan dinilai layak untuk diterapkan.
Hubungan Penggunaan Gadget dengan Keluhan Subjektif Computer Vision Syndrom (CVS) pada Mahasiswa Klinik Fakultas Kedokteran Universitas Kristen Indonesia
Authors: Simanungkalit Bona , Siagan Forman E 
Published: October 2021

ABSTRAK
Latar belakang: Computer Vision Syndrome (CVS) merupakan gangguan penglihatan yang disebabkan karena penggunaan komputer. Gejala yang paling umum terjadi terkait CVS adalah mata tegang, sakit kepala, pandangan buram, mata kering, dan sakit pada leher serta bahu. Computer Vision Syndrome (CVS) dapat muncul segera setelah pemakaian gadget dalam jangka waktu lama atau lebih dari 4 jam namun, terdapat beberapa orang yang mengalami CVS beberapa hari kemudian.
Tujuan: Penelitian ini bertujuan untuk mengetahui Hubungan Penggunaan Gadget dengan Keluhan Subjektif Computer Vision Syndrom (CVS).
Metode: Metode penelitian ini merupakan survey analitik dengan desain penelitian cross sectional. Pengambilan data digunakan dengan menggunakan kuesioner dan pengambilan sampel yang digunakan adalah teknik non random sampling, yaitu purposive sampling yang dipilih berdasarkan kriteria ekslusi dan kriteria inklusi.
Hasil: Dari 245 responden didapatkan sebagian besar responden tidak mengalami Computer Vision Syndrome (CVS) sebanyak 209 responden (85,3%) dan sebanyak 36 responden (14,7%) mengalami Computer Vision Syndrome (CVS), didapatkan sebagian besar responden menggunakan hadphone / tablet, komputer/laptop sebanyak 226 responden (92,2%) dan 19 responden (7,8%) hanya menggunakan handphone / tablet terdapat hubungan penggunaan gadget terhadap keluhan subjektif Computer Vision Syndrome.
Kesimpulan: Dari hasil penelitian didapatkan bahwa durasi penggunaan gadget berpengaruh terhadap timbulnya keluhan subjektif Computer Vision Syndome sebesar 17,3%.
Kata kunci: Computer Vision Syndrome (CVS), gadget, durasi.
Higher Urine Exosomal miR-193a Is Associated With a Higher Probability of Primary Focal Segmental Glomerulosclerosis and an Increased Risk of Poor Prognosis Among Children With Nephrotic Syndrome
Authors: Wang Lixia , Wang Jie , Wang Zhimin , Zhou Jianhua , Zhang Yu 
Published: October 2021

Background: In children, focal segmental glomerulosclerosis (FSGS) is one of the most common primary glomerular diseases leading to end-stage renal disease. Exosomes facilitate communication between cells by transporting proteins and microRNAs. We aimed to investigate the utility of urine exosomal miR-193a for diagnosis and prognosis estimation among patients with primary FSGS, and preliminarily explore the regulation mechanism of exosome secretion from podocytes.Methods: Specimens of urine were obtained from patients with primary FSGS, minimal change nephropathy (MCN) and IgA nephropathy (IgAN), followed by exosome isolation. We quantified urine exosomal miR-193a based on quantitative reverse transcription-polymerase chain reaction, and evaluated its applicability using area-under-receiver-operating-characteristics curves (AUROCs). The semiquantitative glomerulosclerosis index (GSI) was used to evaluate the degree of glomerulosclerosis according to the method of Raij et al. We further used FAM-labeled miR-193a-5p to examine exosome shuttling using confocal microscopy for visualization, and explored the regulation mechanism of exosomes release from podocytes using Fluo-3AM dye.Results: Urine exosomal miR-193a levels were significantly higher in patients with primary FSGS than those with MCN and IgAN. The AUROCs for discriminating between primary FSGS and MCN or IgAN were 0.85 and 0.821, respectively. Urine exosomal miR-193a levels positively correlated with GSI in patients with primary FSGS. We further found that kidney tissues from these patients had increased CD63 expression involving podocytes in non-sclerotic tufts. Exosomes from cultured podocytes could transport miR-193a-5p to recipient cells, potentially through a calcium-dependent release mechanism.Conclusion: Urine exosomal miR-193a might be harnessed as a non-invasive marker for diagnosis and outcome assessment among patients with primary FSGS. Exosomes were potential vehicles for miRNAs shuttling between podocytes, and released from podocytes in a calcium-dependent manner.
Identification of an Immune-Related Prognostic Gene CLEC5A Based on Immune Microenvironment and Risk Modeling of Ovarian Cancer
Authors: Shen Jiacheng , Liu Tingwei , Lv Jia , Xu Shaohua 
Published: October 2021

Objective: To understand the immune characteristics of the ovarian cancer (OC) microenvironment and explore the differences of immune-related molecules and cells to establish an effective risk model and identify the molecules that significantly affected the immune response of OC, to help guide the diagnosis.Methods: First, we calculate the TMEscore which reflects the immune microenvironment, and then analyze the molecular differences between patients with different immune characteristics, and determine the prognostic genes. Then, the risk model was established by least absolute shrinkage and selection operator (LASSO) analysis and combined with clinical data into a nomogram for diagnosis and prediction. Subsequently, the potential gene CLEC5A influencing the immune response of OC was identified from the prognostic genes by integrative immune-stromal analysis. The genomic alteration was explored based on copy number variant (CNV) and somatic mutation data.Results: TMEscore was a prognostic indicator of OC. The prognosis of patients with high TMEscore was better. The risk model based on immune characteristics was a reliable index to predict the prognosis of patients, and the nomogram could comprehensively evaluate the prognosis of patients. Besides, CLEC5A was closely related to the abundance of immune cells, immune response, and the expression of immune checkpoints in the OC microenvironment. OC cells with high expression of CLEC5A increased the polarization of M2 macrophages. CLEC5A expression was significantly associated with TTN and CDK12 mutations and affected the copy number of tumor progression and immune-related genes.Conclusion: The study of immune characteristics in the OC microenvironment and the risk model can reveal the factors affecting the prognosis and guide the clinical hierarchical treatment. CLEC5A can be used as a potential key gene affecting the immune microenvironment remodeling of OC, which provides a new perspective for improving the effect of OC immunotherapy.
Co-Addition of Mg2Si and Graphene for Synergistically Improving the Hydrogen Storage Properties of Mg−Li Alloy
Authors: Huang Xiantun , Liu Haizhen , Duan Xingqing , Lan Zhiqiang , Guo Jin 
Published: October 2021

Mg−Li alloy possesses a high hydrogen capacity. However, the hydrogenation and dehydrogenation performances are still far from practical application. In this work, Mg2Si (MS) and graphene (G) were employed together to synergistically improve the hydrogen storage properties of Mg−Li alloy. The structures of the samples were studied by XRD and SEM methods. The hydrogen storage performances of the samples were studied by nonisothermal and isothermal hydrogenation and dehydrogenation, thermal analysis, respectively. It is shown that the onset dehydrogenation temperature of Mg−Li alloy was synergistically reduced from 360°C to 310°C after co-addition of Mg2Si and graphene. At a constant temperature of 325°C, the Mg−Li−MS−G composite can release 2.7 wt.% of hydrogen within 2 h, while only 0.2 wt.% of hydrogen is released for the undoped Mg−Li alloy. The hydrogenation activation energy of the Mg−Li−MS−G composite was calculated to be 86.5 kJ mol−1. Microstructure and hydrogen storage properties studies show that graphene can act as a grinding aid during the ball milling process, which leads to a smaller particle size for the composites. This work demonstrates that coaddition of Mg2Si and graphene can synergistically improve the hydrogen storage properties of Mg−Si alloy and offers an insight into the role of graphene in the Mg−Li−MS−G composite.
New Insights Into Blue Light Phototherapy in Experimental Trypanosoma cruzi Infection
Authors: Ivanova Natália , Leite Ana Luísa Junqueira , Vieira Marcel Barbosa , Silva Otto Henrique Cezar e , Mota Ludmilla Walter Reis , Costa Guilherme de Paula , Azevedo Cristiano Schetini de , Auharek Sarah Alves , Novaes Romulo Dias , Pinto Kelerson Mauro de Castro , Bianchi Rodrigo Fernando , Talvani André 
Published: October 2021

The search for an effective etiologic treatment to eliminate Trypanosoma cruzi, the causative agent of Chagas disease, has continued for decades and yielded controversial results. In the 1970s, nifurtimox and benznidazole were introduced for clinical assessment, but factors such as parasite resistance, high cellular toxicity, and efficacy in acute and chronic phases of the infection have been debated even today. This study proposes an innovative strategy to support the controlling of the T. cruzi using blue light phototherapy or blue light-emitting diode (LED) intervention. In in vitro assays, axenic cultures of Y and CL strains of T. cruzi were exposed to 460 nm and 40 µW/cm2 of blue light for 5 days (6 h/day), and parasite replication was evaluated daily. For in vivo experiments, C57BL6 mice were infected with the Y strain of T. cruzi and exposed to 460 nm and 7 µW/cm2 of blue light for 9 days (12 h/day). Parasite count in the blood and cardiac tissue was determined, and plasma interleukin (IL-6), tumoral necrosis factor (TNF), chemokine ligand 2 (CCL2), and IL-10 levels and the morphometry of the cardiac tissue were evaluated. Blue light induced a 50% reduction in T. cruzi (epimastigote forms) replication in vitro after 5 days of exposure. This blue light-mediated parasite control was also observed by the T. cruzi reduction in the blood (trypomastigote forms) and in the cardiac tissue (parasite DNA and amastigote nests) of infected mice. Phototherapy reduced plasma IL-6, TNF and IL-10, but not CCL2, levels in infected animals. This non-chemical therapy reduced the volume density of the heart stroma in the cardiac connective tissue but did not ameliorate the mouse myocarditis, maintaining a predominance of pericellular and perivascular mononuclear inflammatory infiltration with an increase in polymorphonuclear cells. Together, these data highlight, for the first time, the use of blue light therapy to control circulating and tissue forms of T. cruzi. Further investigation would demonstrate the application of this promising and potential complementary strategy for the treatment of Chagas disease.