bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational and experimental mechanical performance of a new everolimus-eluting stent purpose-built for left main interventions
Authors: Samant Saurabhi , Wu Wei , Zhao Shijia , Khan Behram , Sharzehee Mohammadali , Panagopoulos Anastasios , Makadia Janaki , Mickley Timothy , Bicek Andrew , Boismier Dennis , Murasato Yoshinobu , Chatzizisis Yiannis S. 
Published: April 2021

AbstractLeft main (LM) coronary artery bifurcation stenting is a challenging topic due to the distinct anatomy and wall structure of LM. In this work, we investigated computationally and experimentally the mechanical performance of a novel everolimus-eluting stent (SYNERGY MEGATRON) purpose-built for interventions to large proximal coronary segments, including LM. MEGATRON stent has been purposefully designed to sustain its structural integrity at higher expansion diameters and to provide optimal lumen coverage. Four patient-specific LM geometries were 3D reconstructed and stented computationally with finite element analysis in a well-validated computational stent simulation platform under different homogeneous and heterogeneous plaque conditions. Four different everolimus-eluting stent designs (9-peak prototype MEGATRON, 10-peak prototype MEGATRON, 12-peak MEGATRON, and SYNERGY) were deployed computationally in all bifurcation geometries at three different diameters (i.e., 3.5, 4.5, and 5.0 mm). The stent designs were also expanded experimentally from 3.5 to 5.0 mm (blind analysis). Stent morphometric and biomechanical indices were calculated in the computational and experimental studies. In the computational studies the 12-peak MEGATRON exhibited significantly greater expansion, better scaffolding, smaller vessel prolapse, and greater radial strength (expressed as normalized hoop force) than the 9-peak MEGATRON, 10-peak MEGATRON, or SYNERGY (p < 0.05). Larger stent expansion diameters had significantly better radial strength and worse scaffolding than smaller stent diameters (p < 0.001). Computational stenting showed comparable scaffolding and radial strength with experimental stenting. 12-peak MEGATRON exhibited better mechanical performance than the 9-peak MEGATRON, 10-peak MEGATRON, or SYNERGY. Patient-specific computational LM stenting simulations can accurately reproduce experimental stent testing, providing an attractive framework for cost- and time-effective stent research and development.
Clinical features and disease severity in an Iranian population of inpatients with COVID-19
Authors: Nabavi Shima , Javidarabshahi Zahra , Allahyari Abolghasem , Ramezani Mohammad , Seddigh-Shamsi Mohsen , Ravanshad Sahar , AkbariRad Mina , Ebrahimzadeh Farnoosh , Khatami Shohre , Emadzadeh Maryam , Saeedian Neda , Zarifian Ahmadreza , Miri Maryam , Rezaeetalab Fariba , Hejazi Sepide , Basiri Reza , Mozdourian Mahnaz 
Published: April 2021

AbstractCoronavirus disease 2019 (COVID-19) can present with a variety of symptoms. Severity of the disease may be associated with several factors. Here, we review clinical features of COVID-19 inpatients with different severities. This cross-sectional study was performed in Imam Reza hospital, Mashhad, Iran, during February–April 2020. COVID-19 patients with typical computed tomography (CT) patterns and/or positive reverse-transcriptase polymerase chain reaction (RT-PCR) were included. The patients were classified into three groups of moderate, severe, and critical based on disease severity. Demographic, clinical, laboratory, and radiologic findings were collected and compared. P < 0.05 was considered statistically significant. Overall, 200 patients with mean age of 69.75 ± 6.39 years, of whom 82 (41%) were female were studied. Disease was severe/critical in the majority of patients (167, 83.5%). Disease severity was significantly associated with age, malignant comorbidities, dyspnea, nausea/vomiting, confusion, respiratory rate, pulse rate, O2 saturation, extent of CT involvement, serum C-reactive protein (CRP), pH, pO2, and aspartate transaminase (P < 0.05). Moreover, complications including shock, coagulopathy, acidosis, sepsis, acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admission, and intubation were significantly higher in patients with higher severities (P < 0.05). O2 saturation, nausea/vomiting, and extent of lung CT involvement were independent predictors of severe/critical COVID-19 (OR 0.342, 45.93, and 25.48, respectively; P < 0.05). Our results indicate O2 saturation, nausea/vomiting, and extent of lung CT involvement as independent predictors of severe COVID-19 conditions. Serum CRP levels and pO2 were also considerably higher patients with higher severity and can be used along with other factors to predict severe disease in COVID-19 patients.
Vegfa promoter gene hypermethylation at HIF1α binding site is an early contributor to CKD progression after renal ischemia
Authors: Sánchez-Navarro Andrea , Pérez-Villalva Rosalba , Murillo-de-Ozores Adrián Rafael , Martínez-Rojas Miguel Ángel , Rodríguez‐Aguilera Jesús Rafael , González Norma , Castañeda-Bueno María , Gamba Gerardo , Recillas-Targa Félix , Bobadilla Norma A. 
Published: April 2021

AbstractChronic hypoxia is a major contributor to Chronic Kidney Disease (CKD) after Acute Kidney Injury (AKI). However, the temporal relation between the acute insult and maladaptive renal response to hypoxia remains unclear. In this study, we analyzed the time-course of renal hemodynamics, oxidative stress, inflammation, and fibrosis, as well as epigenetic modifications, with focus on HIF1α/VEGF signaling, in the AKI to CKD transition. Sham-operated, right nephrectomy (UNx), and UNx plus renal ischemia (IR + UNx) groups of rats were included and studied at 1, 2, 3, or 4 months. The IR + UNx group developed CKD characterized by progressive proteinuria, renal dysfunction, tubular proliferation, and fibrosis. At first month post-ischemia, there was a twofold significant increase in oxidative stress and reduction in global DNA methylation that was maintained throughout the study. Hif1α and Vegfa expression were depressed in the first and second-months post-ischemia, and then Hif1α but not Vegfa expression was recovered. Interestingly, hypermethylation of the Vegfa promoter gene at the HIF1α binding site was found, since early stages of the CKD progression. Our findings suggest that renal hypoperfusion, inefficient hypoxic response, increased oxidative stress, DNA hypomethylation, and, Vegfa promoter gene hypermethylation at HIF1α binding site, are early determinants of AKI-to-CKD transition.
Eye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer’s disease
Authors: Pavisic Ivanna M. , Pertzov Yoni , Nicholas Jennifer M. , O’Connor Antoinette , Lu Kirsty , Yong Keir X. X. , Husain Masud , Fox Nick C. , Crutch Sebastian J. 
Published: April 2021

AbstractThe basis of visual short-term memory (VSTM) impairments in preclinical Alzheimer’s disease (AD) remains unclear. Research suggests that eye movements may serve as indirect surrogates to investigate VSTM. Yet, investigations in preclinical populations are lacking. Fifty-two individuals from a familial Alzheimer’s disease (FAD) cohort (9 symptomatic carriers, 17 presymptomatic carriers and 26 controls) completed the “Object-localisation” VSTM task while an eye-tracker recorded eye movements during the stimulus presentation. VSTM function and oculomotor performance were compared between groups and their association during encoding investigated. Compared to controls, symptomatic FAD carriers showed eye movement patterns suggestive of an ineffective encoding and presymptomatic FAD carriers within 6 years of their expected age at symptom onset, were more reliant on the stimuli fixation time to achieve accuracy in the localisation of the target. Consequently, for shorter fixation times on the stimuli, presymptomatic carriers were less accurate at localising the target than controls. By contrast, the only deficits detected on behavioural VSTM function was in symptomatic individuals. Our findings provide novel evidence that encoding processes may be vulnerable and weakened in presymptomatic FAD carriers, most prominently for spatial memory, suggesting a possible explanation for the subtle VSTM impairments observed in the preclinical stages of AD.
Flatness and boundness of photonic drumhead surface state in a metallic lattice
Authors: Wang Yu , Zhou Xiaoxi , Li Shanshan , Zhang Wenya , Hu Chuandeng , Lu Weixin , Hou Bo 
Published: April 2021

AbstractNodal chain (NC) semi-metals have the degeneracy of interlacing rings in their band structure in momentum space. With the projection of degenerate rings towards crystal boundaries, there is a special type of surface dispersion appearing at surface Brillouin zone and termed drumhead surface state (DSS). Previously, experimental investigations on photonic NC and DSS have been done on metallic photonic crystals at microwave frequencies. However, far-field detection of DSS and its coupling to radiative modes in free space have not been studied. In the work, we analyze the photonic DSS in a metallic lattice by angle-resolved far-field reflection measurement and numerical simulation at terahertz (THz) frequencies, and reveal its flatness and boundness in band structure, even in the radiation continuum. Particularly, the DSS band can be tuned being from negatively dispersive via flat to positively dispersive by a single surface parameter, and the DSS at Γ point in surface Brillouin zone is in fact a symmetry-protected bound state in the continuum. Our results might have some potential applications towards THz photonics.
Revisiting traditional SSR based methodologies available for elephant genetic studies
Authors: Marasinghe M. S. L. R. P. , Nilanthi R. M. R. , Hathurusinghe H. A. B. M. , Sooriyabandara M. G. C. , Chandrasekara C. H. W. M. R. B. , Jayawardana K. A. N. C. , Kodagoda M. M. , Rajapakse R. C. , Bandaranayake P. C. G. 
Published: April 2021

AbstractAsian elephant (Elephas maximus) plays a significant role in natural ecosystems and it is considered as an endangered animal. Molecular genetics studies on elephants’ dates back to 1990s. Microsatellite markers have been the preferred choice and have played a major role in ecological, evolutionary and conservation research on elephants over the past 20 years. However, technical constraints especially related to the specificity of traditionally developed microsatellite markers have brought to question their application, specifically when degraded samples are utilized for analysis. Therefore, we analyzed the specificity of 24 sets of microsatellite markers frequently used for elephant molecular work. Comparative wet lab analysis was done with blood and dung DNA in parallel with in silico work. Our data suggest cross-amplification of unspecific products when field-collected dung samples are utilized in assays. The necessity of Asian elephant specific set of microsatellites and or better molecular techniques are highlighted.
Ka-band planar slotted waveguide array based on groove gap waveguide technology with a glide-symmetric holey metasurface
Authors: Herrán Luis Fernando , Algaba Brazalez Astrid , Rajo-Iglesias Eva 
Published: April 2021

AbstractThe design of a planar slot array in groove gap waveguide technology implemented by glide-symmetric holes as Electromagnetic Band Gap structure is here presented. Despite the advantages of using holes instead of pins in terms of manufacturing simplicity and cost,the larger size of the holes compared to pins needs to be considered when designing slot arrays without grating lobes. A 1 to 4 corporate feed network is designed using this technology as well. Corrugations are included to further reduce the grating lobes. Experimental results support the viability of the proposed concept for designing glide-symmetric planar arrays of any size.
Transcriptome analysis identifies differentially expressed genes in the progenies of a cross between two low phytic acid soybean mutants
Authors: Jin Hangxia , Yu Xiaomin , Yang Qinghua , Fu Xujun , Yuan Fengjie 
Published: April 2021

AbstractPhytic acid (PA) is a major antinutrient that cannot be digested by monogastric animals, but it can decrease the bioavailability of micronutrients (e.g., Zn and Fe). Lowering the PA content of crop seeds will lead to enhanced nutritional traits. Low-PA mutant crop lines carrying more than one mutated gene (lpa) have lower PA contents than mutants with a single lpa mutant gene. However, little is known about the link between PA pathway intermediates and downstream regulatory activities following the mutation of these genes in soybean. Consequently, we performed a comparative transcriptome analysis using an advanced generation recombinant inbred line with low PA levels [2mlpa (mips1/ipk1)] and a sibling line with homozygous non-mutant alleles and normal PA contents [2MWT (MIPS1/IPK1)]. An RNA sequencing analysis of five seed developmental stages revealed 7945 differentially expressed genes (DEGs) between the 2mlpa and 2MWT seeds. Moreover, 3316 DEGs were associated with 128 metabolic and signal transduction pathways and 4980 DEGs were annotated with 345 Gene Ontology terms related to biological processes. Genes associated with PA metabolism, photosynthesis, starch and sucrose metabolism, and defense mechanisms were among the DEGs in 2mlpa. Of these genes, 36 contributed to PA metabolism, including 22 genes possibly mediating the low-PA phenotype of 2mlpa. The expression of most of the genes associated with photosynthesis (81 of 117) was down-regulated in 2mlpa at the late seed developmental stage. In contrast, the expression of three genes involved in sucrose metabolism was up-regulated at the late seed developmental stage, which might explain the high sucrose content of 2mlpa soybeans. Furthermore, 604 genes related to defense mechanisms were differentially expressed between 2mlpa and 2MWT. In this study, we detected a low PA content as well as changes to multiple metabolites in the 2mlpa mutant. These results may help elucidate the regulation of metabolic events in 2mlpa. Many genes involved in PA metabolism may contribute to the substantial decrease in the PA content and the moderate accumulation of InsP3–InsP5 in the 2mlpa mutant. The other regulated genes related to photosynthesis, starch and sucrose metabolism, and defense mechanisms may provide additional insights into the nutritional and agronomic performance of 2mlpa seeds.
Postoperative cognitive functions in patients with benign intracranial lesions
Authors: Bette Stefanie , Ruhland Julia M. , Wiestler Benedikt , Barz Melanie , Meyer Bernhard , Zimmer Claus , Ryang Yu-Mi , Ringel Florian , Gempt Jens 
Published: April 2021

AbstractThe aim of this study was to assess pre- and postoperative cognitive functions in patients who underwent surgery for benign intracranial lesions. In total, 58 patients (21 men, 37 women, mean age 51.6 years [range 24–76 years]) with benign intracranial lesions (including benign tumors and vascular lesions) and neuralgia of the trigeminal nerve were included in this prospective study. Extensive cognitive testing was used to categorize attention, memory, and executive functions. Mood and pain were assessed preoperatively (t0, mean 3.7 days before surgery), immediately after surgery/during inpatient stay (t1, mean 7.6 days after surgery), and at first outpatient check-up (t2, mean 99.5 days after surgery). All 58 patients were tested at t0 and t1, but at t2 only 24 patients were available at t2. The data were categorized as improvement/stable condition or deterioration and shown as percentages. The pre- and postoperative values of BDI-II and mood were compared by the Wilcoxon test for paired samples. Binary logistic regression analyses were performed to identify parameters influencing cognition in the subgroup of meningioma patients. Immediately after surgery (t1), the percentage of patients with improvement/stable condition was > 50% in all categories in the majority of subtests (attention: 12/14 subtests, memory: 11/13 subtests, executive functions: 6/9 subtests). Similar results were shown at t2. Mood and pain did not change significantly after surgery. Factors like age, Karnofsky performance status, and tumor volume were not shown as significant influencing factors for cognitive functions in meningioma patients. The results of this study suggest that—in contrast to neuroepithelial tumors—cognitive functions do not deteriorate after surgery of benign intracranial lesions. Further studies are necessary to evaluate the results of this study.
Low loss and high performance interconnection between standard single-mode fiber and antiresonant hollow-core fiber
Authors: Suslov Dmytro , Komanec Matěj , Numkam Fokoua Eric R. , Dousek Daniel , Zhong Ailing , Zvánovec Stanislav , Bradley Thomas D. , Poletti Francesco , Richardson David J. , Slavík Radan 
Published: April 2021

AbstractWe demonstrate halving the record-low loss of interconnection between a nested antiresonant nodeless type hollow-core fiber (NANF) and standard single-mode fiber (SMF). The achieved interconnection loss of 0.15 dB is only 0.07 dB above the theoretically-expected minimum loss. We also optimized the interconnection in terms of unwanted cross-coupling into the higher-order modes of the NANF. We achieved cross-coupling as low as −35 dB into the LP$$_{11}$$

11

mode (the lowest-loss higher-order mode and thus the most important to eliminate). With the help of simulations, we show that the measured LP$$_{11}$$

11

mode coupling is most likely limited by the slightly imperfect symmetry of the manufactured NANF. The coupling cross-talk into the highly-lossy LP$$_{02}$$

02

mode ($$>2000$$

>
2000

dB/km in our fiber) was measured to be below −22 dB. Furthermore, we show experimentally that the anti-reflective coating applied to the interconnect interface reduces the insertion loss by 0.15 dB while simultaneously reducing the back-reflection below −40 dB over a 60 nm bandwidth. Finally, we also demonstrated an alternative mode-field adapter to adapt the mode-field size between SMF and NANF, based on thermally-expanded core fibers. This approach enabled us to achieve an interconnection loss of 0.21 dB and cross-coupling of −35 dB into the LP$$_{11}$$

11

mode.
The effect of control rods on the reactivity and flux distribution of BWR 4 bundle using MCNPX Code
Authors: Mustafa Sayed. Saeed. 
Published: April 2021

AbstractThis paper has three main objectives related to the neutronic and burnup analysis of the BWR (Boiling Water Reactor) Four-Lattice. The first objective is to provide partial validation of the MCNPX code for this lattice by comparing its results with Scale-5.1 results. Validation of the MCNPX to calculate effective multiplication factor and reactivity rod worth for the F-Lattice is provided. This is carried out in case of instantly removing the control blade and replacing it with a graphite moderator. Moreover, spatial neutron flux distributions using F-mesh card over the bundle and the control blade are investigated at inserting and withdrawing the B4C. The second objective is to perform parametric design studies of the F-Lattice. Areas of particular interest are the effect of increased or decreased blade width on the neutron flux throughout the bundle. It is found that the presence of carbon in the control blade at withdrawing the B4C makes the reactor supercritical, (K-eff = 1.22206). On the other hand, the use of B4C blade presents (K-eff = 0.93521). Consequently, the reactivity of 10% B4C thinner case is higher that of 10% B4C thicker. The simulation also showed that the B4C blade had an effective role in decreasing the thermal flux at the periphery of the bundle. This is contrast to the effect of carbon that moderates fast to thermal neutrons. The third part of this work aims at studying the burnup calculations using MCNPX code for 30 days burn with 1 day time step then for 20 months burn with 2 week time steps for the lattice. At the end of the work, it is very important to determine the most proper bundle model that achieves a prolonged fuel burn and flatting thermal flux distribution. For reaching this goal, three cases (B4C, 10% thinner of B4C and 10% thicker) are simulated by MCNPX code till 70 GWd/ton. It is found that the B4C and 10% thicker are the appropriate models that can satisfy the safety considerations of the Compact Modular Boiling Water Reactor.
Keeping an eye on the use of eye-lens weight as a universal indicator of age for European wild rabbits
Authors: Vaquerizas Patricia H. , Santoro Simone , Delibes-Mateos Miguel , Castro Francisca , Villafuerte Rafael 
Published: April 2021

AbstractAccurate methods for age determination are critical to the knowledge of wildlife populations' age structure and, therefore, to their successful management. The reliability of age estimation may have profound economic and ecological consequences on the management of the European wild rabbits, Oryctolagus cuniculus, in its native and introduced range, where it is a keystone species and a major pest, respectively. As in other mammal species, European rabbits' age is often estimated using the Gompertz relationship between age and lens' weight. The growth rate formula has been developed based on data collected from European rabbits introduced in Australia, where a single subspecies (O. cuniculus cuniculus, Occ) is present. However, this curve has never been validated in the species native range, the Iberian Peninsula, where two subspecies (Occ, and O. c. algirus, Oca) coexist naturally. In this study, we tested the relationship between age and lens' weight using 173 Occ and 112 Oca wild rabbits that were surveyed in two experimental facilities in Spain. Our findings show that, in the native range, the published growth curve formula fits well Occ but not Oca data. Therefore, we recommend using the formula reported in this study to estimate the age of Oca (Lens dry weight = 240 × 10(−64.9/(Age+32))). This study supports Oca rabbits' distinctiveness revealed by previous studies, which suggests that management interventions should be applied to protect this subspecies whose distribution range is very narrow and whose populations seem to be declining. More broadly, our findings point to the importance of testing the suitability of growth curves defined for other species with different genetic forms as occurs in the European wild rabbit case.