bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptional response of the calcification and stress response toolkits in an octocoral under heat and pH stress
Authors: Vargas Sergio , Zimmer Thorsten , Conci Nicola , Lehmann Martin , Wörheide Gert 
Published: November 2021

AbstractUp to one‐third of all described marine species inhabit coral reefs, but the future of these hyperdiverse ecosystems is insecure due to local and global threats, such as overfishing, eutrophication, ocean warming and acidification. Although these impacts are expected to have a net detrimental effect on reefs, it has been shown that some organisms such as octocorals may remain unaffected, or benefit from, anthropogenically induced environmental change, and may replace stony corals in future reefs. Despite their potential importance in future shallow‐water coastal environments, the molecular mechanisms leading to the resilience to anthropogenically induced stress observed in octocorals remain unknown. Here, we use manipulative experiments, proteomics and transcriptomics to show that the molecular toolkit used by Pinnigorgia flava, a common Indo‐Pacific gorgonian octocoral, to deposit its calcium carbonate skeleton is resilient to heat and seawater acidification stress. Sublethal heat stress triggered a stress response in P. flava but did not affect the expression of 27 transcripts encoding skeletal organic matrix (SOM) proteins. Exposure to seawater acidification did not cause a stress response but triggered the downregulation of many transcripts, including an osteonidogen homologue present in the SOM. The observed transcriptional decoupling of the skeletogenic and stress‐response toolkits provides insights into the mechanisms of resilience to anthropogenically driven environmental change observed in octocorals.
Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) sensitize melanoma cells to MEK inhibition and inhibit metastasis and relapse by inducing degradation of AXL
Authors: Chen Yingshi , Zhang Yiwen , Chen Siqi , Liu Weiwei , Lin Yingtong , Zhang Hui , Yu Fei 
Published: November 2021

AbstractMelanoma is highly heterogeneous with diverse genomic alterations and partial therapeutic responses. The emergence of drug‐resistant tumor cell clones accompanied by a high AXL expression level is one of the major challenges for anti‐tumor clinical care. Recent studies have demonstrated that high AXL expression in melanoma cells mediated drug resistance, epithelial‐mesenchymal transition (EMT), and elevated survival of cancer stem cells (CSCs). Given that we have identified several non‐steroidal anti‐inflammatory drugs (NSAIDs) including aspirin potently induce the degradation of AXL, we questioned whether NSAIDs could counteract the AXL‐mediated neoplastic phenotypes. In this study, we found that NSAIDs downregulate PKA activity via the PGE2/EP2/cAMP/PKA signaling pathway and interrupt the PKA‐dependent interaction between CDC37 and HSP90, resulting in an incorrect AXL protein folding and finally AXL degradation through the ubiquitination‐proteasome system (UPS) pathway. Furthermore, NSAIDs not only sensitized the MEK inhibitor treatment but also reduced EMT and relapse mediated by AXL in tumor tissue. Our findings suggest that the combination of inhibitors and NSAIDs, especially aspirin, could be a simple but efficient modality to treat melanoma in which AXL is a key factor for drug resistance, metastasis, and relapse.
Clinical outcome of cord blood transplantation for nine children with juvenile myelomonocytic leukemia receiving fludarabine‐busulfan‐cyclophosphamide‐based conditioning
Authors: Li Guifang , Sun Zimin , Geng Liangquan , Wan Xiang , Zhu Xiaoyu , Tang Baolin , Tong Juan , Yao Wen , Song Kaidi , Qiang Ping , Zhang Lei , Zhang Xuhan , Zhang Shiyang , Liu Huilan 
Published: November 2021

AbstractBackgroundJuvenile myelomonocytic leukemia (JMML) is a rare hematological malignancy in young children and can only be cured through the allogeneic stem cell transplantation.ProcedureWe have retrospectively analyzed the outcomes of nine children with JMML after unrelated cord blood transplantation (UCBT).ResultsEight patients who have received a myeloablative conditioning regimen of fludarabine (FLU), busulfan (BU), and cyclophosphamide (CY) have gotten engraftment. None of the nine patients has relapsed following initial UCBT. Six patients are still alive and in complete remission after UCBT with a median observation time of 43 months (range: 10–80 months).ConclusionsThis study shows that UCBT with FLU‐BU‐CY conditioning regimen can represent a suitable option for children with JMML.
The impact of Chinese import competition on Italian manufacturing
Authors: Citino Luca , Linarello Andrea 
Published: November 2021

AbstractThis paper documents the effects of increased import competition from China on the Italian labor market. In line with recent studies, we take two complementary approaches and study both the effects on local labor markets and on manufacturing workers. Our analysis shows that the Italian local labor markets which were more exposed to Chinese trade by means of their industry composition ended up suffering larger manufacturing and overall employment losses. Nevertheless, back‐of‐the‐envelope calculations suggest that the aggregate effect on total manufacturing employment is modest. At the individual level, contrary to what has been documented for many developed countries, workers initially employed in more exposed manufacturing industries did not suffer long‐term losses in terms of lower earnings or more discontinuous careers. While they were indeed less likely than other similar workers to continue working in manufacturing, they were also able to carry out successful transitions toward the non‐tradable sector, in other areas with better job opportunities.
Study of the Hydraulic Performances of Two Inducers in Water—CO2 Mixture—Toward Performance Improvement With Suppression of Prerotation
Authors: Tomov Petar , Pora Loic , Paridaens Richard , Magne Théodore , Kebdani Mohamed , Khelladi Sofiane , Bakir Farid 
Published: November 2021

Abstract
The inducers increase the pressure available at the inlet of the impellers of centrifugal pumps. This technological solution may induce instabilities, such as prerotating flow at partial flow rates. The scientific literature offers studies on the cavitation in the inducers, as well as on the associated instabilities. However, studies describing devices that improve the behavior in these unstable regimes are rare. This is particularly true for fluids like aviation fuels or liquids with dissolved gases. In this work we expose, an experimental study for two axial inducers carried out at low flow rates in cavitating and noncavitating regimes in a closed-loop equipped with a transparent test pipe. The working liquid is water with and without dissolved CO2. We employ a camera and a high-speed camera to take the photographs of the dynamics of the cavitation structures. The experimental campaign provided results of head breakdown comparison. The added dissolved CO2 gas at a concentration of 300 mg L–1 does not change the overall inducers' performance in noncavitating regime. The paper presents also the impact of some of inducers' geometrical parameters on their cavitating performance. The authors observed prerotating flow instability, which they tried to decrease by incorporating a grooved ring into the inlet side of the inducers. It is found that prerotating structures are much less developed in the upstream when a grooved ring is employed.
Stochastic Method to Predict Effects of Roll Grinding Deviations on Sheet Flatness in Cold Rolling
Authors: Zhang Feng , Malik Arif 
Published: November 2021

Abstract
Industrial measurements of the diameter profiles of work-rolls used in cold sheet rolling are applied with a stochastic roll-stack model to better understand how residual error from the roll grinding process affects the rolled sheet flatness quality. Roll diameter measurements taken via a noncontact, optical device on new, warm, and worn work-rolls show that the diameter deviations vary along the roll lengths, across roll samples, and at different operational states, suggesting a multidimensional random field problem. Studies are conducted for a 4-high rolling mill with 301 stainless steel sheet to investigate the reliability in achieving target flatness considering the work-roll diameter random field. Also investigated is the sensitivity of the flatness reliability to roll diameter deviations at different locations along the roll lengths and for the three operational states (newly machined, warm, and worn following several passes). The results lead to several key findings. Foremost, it is shown that an assumption of statistical independence among the residual grinding errors at different roll axis locations is improper. Furthermore, it is demonstrated that, for the measured grinding error correlation patterns, the roll diameter deviations external to the roll/sheet contact region play an important role in contributing to flatness defects within the sheet and that these influences vary according to the roll operational state (new, warm, worn). The presented stochastic model and applied measurement data thus provide for a new understanding into how roll grinding performance influences dimensional quality in the sheet rolling process.
Qualitative assessment of caustic soda injury in Liberia
Authors: Zawolo Jethro , Cohn Keri A , Kawah-Baysah Maima , Weah-Chenoway Salome , Gbozee Lawuobah , Vinograd Alexandra M 
Published: November 2021

ObjectivesThis study explored lye (caustic soda, sodium hydroxide) use in Liberia, knowledge about its risks and injury prevention programmes.DesignA qualitative semistructured interview study.SettingFocus groups occurred in six Liberian counties between April and August 2016.PatientsTwo previously identified stakeholder groups included parents of children under 5 years and adults identifying as soap makers.InterventionsInterview guides were written. Participants were recruited by convenience and snowball sampling. Transcribed audio-recorded discussions were analysed using the constant comparative approach.Main outcome measuresParticipants were enrolled until thematic saturation was reached.ResultsNinety-six adults participated. Participants described how lye entered the home, its use, storage, lye-related injuries and treatments, and injury prevention programmes.ConclusionsLye is commonly used and stored in Liberian homes despite recognition of its danger. A successful injury prevention programme must interrupt this cycle and find programming and legislative change to which the community is receptive.
How can we better integrate the prevention, treatment, control and elimination of neglected tropical diseases with other health interventions? A systematic review
Authors: Banda Gift Treighcy , Deribe Kebede , Davey Gail 
Published: November 2021

BackgroundGlobally, about 1.7 billion people living in poverty are affected by one or more of a group of disabling, disfiguring and poverty-promoting conditions known as neglected tropical diseases (NTDs). Major global health actors, like the WHO, have endorsed a shift from vertical to integrated NTD management.ObjectiveThis systematic review aimed to evaluate how integration is being conducted and how we can improve it.MethodsPubMed, Medline, Cochrane library, Web of Science, Trip, Embase, Global Health and Google Scholar were searched from 1 April to 22 July 2020.We included peer-reviewed articles published between 1 January 2000 and 22 July 2020 in English.ResultsDatabase searches produced 24 565 studies, of which 35 articles met the inclusion criteria. Twenty of these articles were conducted in sub-Saharan Africa. Twenty articles were also published between 2015 and 2020. Literature revealed that NTDs have been integrated—among themselves; with water, sanitation and hygiene programmes; with vector control; with primary healthcare; with immunisation programmes; and with malaria management. Integrated mass drug administration for multiple NTDs was the most common method of integration. The three complex, yet common characteristics of successful integration were good governance, adequate financing and total community engagement.ConclusionThe dataset identified integrated management of NTDs to be cost effective and potentially to increase treatment coverage. However, the identified modes of integration are not exclusive and are limited by the available literature. Nonetheless, integration should urgently be implemented, while considering the programmatic and sociopolitical context.PROSPERO registration numberThe study protocol was registered with PROSPERO number, CRD42020167358.
Study protocol: a multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH)
Authors: Brennan Paul Noel , MacMillan Mark , Manship Thomas , Moroni Francesca , Glover Alison , Graham Catriona , Semple Scott , Morris David M , Fraser Alasdair R , Pass Chloe , McGowan Neil W A , Turner Marc L , Lachlan Neil , Dillon John F , Campbell John D M , Fallowfield Jonathan Andrew , Forbes Stuart J 
Published: November 2021

IntroductionLiver cirrhosis is a growing global healthcare challenge. Cirrhosis is characterised by severe liver fibrosis, organ dysfunction and complications related to portal hypertension. There are no licensed antifibrotic or proregenerative medicines and liver transplantation is a scarce resource. Hepatic macrophages can promote both liver fibrogenesis and fibrosis regression. The safety and feasibility of peripheral infusion of ex vivo matured autologous monocyte-derived macrophages in patients with compensated cirrhosis has been demonstrated.Methods and analysisThe efficacy of autologous macrophage therapy, compared with standard medical care, will be investigated in a cohort of adult patients with compensated cirrhosis in a multicentre, open-label, parallel-group, phase 2, randomised controlled trial. The primary outcome is the change in Model for End-Stage Liver Disease score at 90 days. The trial will provide the first high-quality examination of the efficacy of autologous macrophage therapy in improving liver function, non-invasive fibrosis markers and other clinical outcomes in patients with compensated cirrhosis.Ethics and disseminationThe trial will be conducted according to the ethical principles of the Declaration of Helsinki 2013 and has been approved by Scotland A Research Ethics Committee (reference 15/SS/0121), National Health Service Lothian Research and Development department and the Medicine and Health Care Regulatory Agency-UK. Final results will be presented in peer-reviewed journals and at relevant conferences.Trial registration numbersISRCTN10368050and EudraCT; reference 2015-000963-15
Early prescribing outcomes after exporting the EQUIPPED medication safety improvement programme
Authors: Vaughan Camille P , Hwang Ula , Vandenberg Ann E , Leong Traci , Wu Daniel , Stevens Melissa B , Clevenger Carolyn , Eucker Stephanie , Genes Nick , Huang Wennie , Ikpe-Ekpo Edidiong , Nassisi Denise , Previl Laura , Rodriguez Sandra , Sanon Martine , Schlientz David , Vigliotti Debbie , Hastings S Nicole 
Published: November 2021

Enhancing quality of prescribing practices for older adults discharged from the Emergency Department (EQUIPPED) aims to reduce the monthly proportion of potentially inappropriate medications (PIMs) prescribed to older adults discharged from the ED to 5% or less. We describe prescribing outcomes at three academic health systems adapting and sequentially implementing the EQUIPPED medication safety programme.EQUIPPED was adapted from a model developed in the Veterans Health Administration (VA) and sequentially implemented in one academic health system per year over a 3-year period. The monthly proportion of PIMs, as defined by the 2015 American Geriatrics Beers Criteria, of all medications prescribed to adults aged 65 years and older at discharge was assessed for 6 months preimplementation until 12 months postimplementation using a generalised linear time series model with a Poisson distribution.The EQUIPPED programme was translated from the VA health system and its electronic medical record into three health systems each using a version of the Epic electronic medical record. Adaptation occurred through local modification of order sets and in the generation and delivery of provider prescribing reports by local champions. Baseline monthly PIM proportions 6 months prior to implementation at the three sites were 5.6% (95% CI 5.0% to 6.3%), 5.8% (95% CI 5.0% to 6.6%) and 7.3% (95% CI 6.4% to 9.2%), respectively. Evaluation of monthly prescribing including the twelve months post-EQUIPPED implementation demonstrated significant reduction in PIMs at one of the three sites. In exploratory analyses, the proportion of benzodiazepine prescriptions decreased across all sites from approximately 17% of PIMs at baseline to 9.5%–12% postimplementation, although not all reached statistical significance.EQUIPPED is feasible to implement outside the VA system. While the impact of the EQUIPPED model may vary across different health systems, results from this initial translation suggest significant reduction in specific high-risk drug classes may be an appropriate target for improvement at sites with relatively low baseline PIM prescribing rates.
Time Management Of Teachers And Its Relationship To Teaching Performance
Authors: Olivo Marylin G. 
Published: November 2021

This was a descriptive-correlational applied research which determined and analyzed the time management strategies of public elementary teachers in a district. The time management strategies of the teachers were related to their teaching performance. There were 103 elementary teachers in a district as respondents of the study. Since all teachers in the district were included as respondents of the study, the complete enumeration technique was employed as sampling technique. A time management questionnaire was developed by the researcher based on the activities that teachers need to accomplish and distributed with the help of the principals. The teachers indicated how many hours they spent on a particular task on a 24-hour basis. Weighted mean was used in analyzing the data on time management and Pearson R for the relationship of the time management of teachers and their teaching performance. Findings revealed that teachers were mostly very satisfactory in rendering their work, classroom teaching got the greatest number of time allotment among the teachers, teachers’ time management strategies ranged from using the internet for their needs in teaching to listing important tasks for the day to planning before classes start and working overtime at home to do tasks, work delegation was observed to be the least in their strategies to manage time. Furthermore, findings in this study showed that the teaching performance ratings of the teachers were not influenced by their time management strategies. It could be the tendency because most teachers had very satisfactory ratings. No one got satisfactory rating and only 12 were outstanding. If time management was not a factor, as the relationship test showed acceptance of null hypothesis, then the factor that determined or predicted teaching performance should be explored. The research then recommend that teachers should keep up with their positive teaching performance by giving the same passion and commitment towards work, they must continue giving most of their time in school to classroom instruction in order to produce pupils who are imbued with right values and knowledge and skills competence and they must embrace the challenge of the work responsibilities inherent to being a teacher. Teachers had practiced good time management because they allotted more time to classroom teaching and preparations to their core tasks as teachers. An action plan was developed to strengthen and sustain the time management strategies of teachers
The Graduates Tracer Study: Bachelor of Elementary Education Program
Authors: Abana Adona S. , Ramos Andy B. , Gumarang Jr. Bernardo K. , Tarun Jaine Z. 
Published: November 2021

The study assessed the impact of the Bachelor of Elementary Education program in the life of its graduates in terms of their employability and professional competencies based on the perceptions of graduates and their employers. The survey method was used in the study to determine the graduates' status and performance. There are 250 BEEd graduates involved in the study. Descriptive statistics such as frequency, percent, and arithmetic mean were utilized to determine and describe the profile of graduates and employers, the trend in the employment of graduates for the term being studied, the employers’ assessment of the graduates in terms of their knowledge and understanding of their field of specialization, qualities, general skills and specialized skills generally expected of them in order to succeed in their teaching performance, and the over-all preparation of graduates acquired from the University for the type of work they are currently engaging and other skills needed for their future demands. The data generated from the employers' assessment of the variables mentioned was further analyzed and categorized to generate interrelated thoughts/themes that will emerge from the data. The results of the study showed that graduates of the program are competent because most of the graduates are licensed professionals, employed with regular or permanent status. However, it has been found that graduates need to gain innovative skills such as, research and the use of information communication and technology. The findings can be used as the basis of the program in improving the curriculum and instruction.
The Effect of Golden Sea Cucumber (Stichopus hermanii) Extracts to Serum LDL Cholesterol level as a Result of Insulin Resistence
Authors: Setianingsih Herin , Putri Fatima Sari Suryono , Desi Wahyu Prasasti Mutia , Yatnasari Erlina 
Published: November 2021

ABSTRACT
Diabetes mellitus is a metabolic disease characterized by conditions of hyperglycemia as a result of abnormalities in the secretion of the insulin hormone, the work of the insulin hormone, or both. Metabolic disorders caused by diabetes cause lipolysis to increase, thereby increasing the level of VLDL, which will be converted to LDL. LDL disorders are the effects of insulin resistance. Streptozotocin (STZ) can increase serum LDL cholesterol serum levels due to the mechanism of ROS formation. Golden sea cucumber act as anti-hyperlipidemic because they contain EPA-DHA, saponins, and flavonoids. The purpose of these studies to determine the effect of Golden sea cucumber act as anti-hyperlipidemic. Experimental laboratory research is done using the post-test only control group design method. Using simple random sampling with 25 white male Wistar rats divided into five groups, all rats were given standard feeding. Group 1 without STZ induced, group 2-5 were induced STZ first, and then group 3-5 were given golden sea cucumber extract for 21 days with dose 4,25 mg/kg BW, 8,5 mg/kg BW, 12,75 mg/kg BW, per day respectively. At the end of the study, the LDL serum level was measured. The result of One – Way Anova test showed LDL cholesterol serum levels of group rats with STZ induction and given 12,75 mg/kg BW golden sea cucumber extracts (x=7,4 mg/dl) significantly decreased (p=0,005) compared to LDL cholesterol levels of group rats which were only induced by STZ without given golden sea cucumber extracts (x=12,6 mg/dl). This research showed that the administration 12,75mg/kg BW of golden sea cucumber extracts for 21 days reduced serum LDL cholesterol levels because golden sea cucumber contains compounds that work as antioxidants.