bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors of recurrent abdominal pain in adolescents
Authors: Kadim Muzal , Setiani Anjar , Hendarto Aryono 
Published: July 2021

Background Recurrent abdominal pain is 2-4% of all cases encountered by pediatricians. Risk factors vary among countries. There is no data on prevalence and risk factors of recurrent abdominal pain in adolescents in Indonesia.
Objective To evaluate prevalence and risk factors of recurrent abdominal pain in junior high school students.
Methods A cross-sectional study was performed among junior high school students in South Jakarta who experienced recurrent abdominal pain according to Roma III criteria. Students allowed by their parents to participate to this study were asked to complete a Roma III questionnaire. Data about sociodemographic and history of recurrent abdominal pain among the parents were also collected using a questionnaire.
ResultsThree hundred ninety-six adolescents participated in this study, 17.2% among them experiencing recurrentabdominal pain. Irritable bowel syndrome (IBS) was the most common type (42.6%), followed by functional dyspepsia (30.9%), functional abdominal pain syndrome (11.8%), functional abdominal pain (10.3%), and abdominal migraine (4.4%). The risk factor most responsible was anxious personality (OR 3.86; 95%CI 2.05 to 7.29, P<0.001). Other risk factors that contribute were female, age > 13 years, and middle to lower family income.
Conclusions Prevalence of recurrent abdominal pain in adolescents is 17.2%. Irritable bowel syndrome is the most common type. The risk factors are anxious personality, female, age > 13 years, and middle to lower family income.
Relationship between aspartate aminotransferase to platelet ratio index and liver injury in pediatric sepsis
Authors: Godlief Robby , Hakim Dzulfikar Djalil Lukmanul , Prasetyo Dwi 
Published: July 2021

Background Sepsis-associated liver injury (SALI) is one of the main clinical manifestations of sepsis, as well as an independent risk factor for multiple organ dysfunction syndrome and mortality in pediatric sepsis. The early warning biomarkers for identifying SALI remain poorly defined.
Objective To analyze the relationship between aspartate aminotransferase to platelet ratio index (APRi) and liver injury occurrence in pediatric sepsis, as well as determine the APRi cutoff value for early identification of SALI.
Methods This retrospective study used secondary data derived from January 2019 to August 2020. The study population comprised admitted children aged 1 month to <18 years who met the criteria for sepsis, and had aspartate aminotransferase (AST) and platelet laboratory parameters checked in the first 24 hours of sepsis and before administration of antibiotics. Pearson’s Chi-square test was used to analyze for correlations. Estimation of the APRi cutoff value in the early occurrence of SALI was performed with logistic regression analysis and receiver operating characteristic (ROC) curve.
Results Of the 112 subjects, 94.6% were categorized as having septic shock and 48.2% had SALI. Logistic regression revealed that APRi was a significant predictor of SALI, as indicated by cut-off 4.726 [OR 1.098; 95%CI 1.002 to1.203; P=0.045]. The area under the curve (AUC) was 0.831 or 83.1%, which was classified as strong (80-90%).
Conclusion The APRi is a reliable early predictor of SALI in pediatric sepsis, as indicated by an increase in APRi (> 4.726) within the first 24 hours of sepsis.
3-year survival rate in acute lymphoblastic leukemia: comparison of ALL-2006 and ALL-2013 Protocols
Authors: Meirizkia Avyandita , Ayu Dewi Rosariah , Indra Raden Muhammad , Sari Dian Puspita 
Published: July 2021

Background With advances in supportive and risk-stratified therapy, the 5-year survival rate of acute lymphoblastic leukemia has reached 85.5%. The ALL-2006 treatment protocol was modified and renamed the ALL-2013 protocol, with dose and duration changes.
Objective To compare outcomes of the ALL-2006 and ALL-2013 protocols, with regards to mortality, remission, relapse, and three-year survival rates.
Methods This was retrospective cohort study. Subjects were acute lymphoblastic leukemia (ALL) patients treated from 2011 to 2018 in Mohamad Hoesin Hospital, Palembang, South Sumatera. The three-year survival rates, relapse, remission rates and comparison of ALL-2006 and ALL-2013 protocols were analyzed with Kaplan-Meier method.
Results Mortality was significantly correlated with age at diagnosis <1 year and >10 years, hyperleukocytosis, and high-risk disease status. Patients aged 1 to 10 years, with leukocyte count <50,000/mm3 and standard-risk status had significantly higher likelihood of achieving remission. Mortality was not significantly different between the ALL-2006 protocol group [70.6%; mean survival 1,182.15 (SD 176.89) days] and the ALL-2013 protocol group [72.1%; mean survival 764.23 (SD 63.49) days]; (P=0.209). Remission was achieved in 39.2% of the ALL-2006 group and 33% of the ALL-2013 group (P>0.05). Relapse was also not significantly different between the two groups (ALL-2006: 29.4% vs. ALL-2013: 17.9%; P>0.05). Probability of death in the ALL-2006 group was 0.3 times lower than in the ALL-2013 group (P<0.05), while that of the high-risk group was 3 times higher. Remission was 2.19 times higher in those with leukocyte <50,000/mm3 compared to those with hyperleukocytosis. In addition, relapse was significantly more likely in high-risk patients (HR 2.96; 95%CI 1.22 to 7.19). Overall, the 3-year survival rate was 33%, with 41.7% in the ALL-2006 group and 30.7% in the ALL-2013 group.
Conclusion Three-year survival rate of ALL-2006 protocol is higher than that of ALL-2013 protocol but is not statistically significant. Age at diagnosis <1 year and >10 years, hyperleukocytosis, and high-risk group are significantly correlated with higher mortality and lower remission rates. However, these three factors are not significantly different in terms of relapse.
Presepsin level as risk factor for mortality in premature infants with neonatal sepsis
Authors: Romli Muhammad Ifan , Yuniati Tetty , Hilmanto Dany 
Published: July 2021

Background Prematurity is a risk factor of neonatal sepsis and its associated morbidities and mortality. Most deaths in neonatal sepsis occur within the first seven days. Presepsin has been reported as one of the earliest biomarkers for predicting mortality.
Objective To determine the association between presepsin levels and mortality risk, as well as the optimal presepsin cut-off point for predicting mortality, in premature infants with neonatal sepsis
.Method This was an observational prospective cohort study on 62 preterm infants born at 28 to <37 weeks’ gestation. We recorded clinical and laboratory characteristics, performed blood culture, and measured presepsin levels at initial diagnosis of sepsis. Subjects were followed for seven days and their outcome (death or survival) recorded. We evaluated the association between clinical and laboratory characteristics, including presepsin levels, with sepsis outcome. We also constructed a receiver-operator characteristics curve to determine the optimal cut-off point of presepsin as a predictor of sepsis mortality.
Results Only blood culture results (P=0.006) and presepsin level (P<0.001) were significantly associated with sepsis outcome on the seventh day. The optimal presepsin cut-off value for predicting mortality was 1057 ng/mL, with an area under curve of 80.4%, sensitivity of 60.71%, and specificity of 88.24%. A presepsin level of >1057 ng/mL was associated with increased mortality [RR 3.02; 95%CI 68.3 to 89.4; P<0.001].
Conclusion In preterm infants with neonatal sepsis, an elevated presepsin level at diagnosis is a significant risk factor for mortality within seven days. Presepsin can be used as an early biomarker of sepsis outcome.
Passive Cross-Holding in a Stackelberg Oligopoly
Authors: Ma Hongkun , Zeng Chenhang 
Published: July 2021

Abstract
We show that bilateral cross-holding can be profitable for firms with symmetric technologies in a Stackelberg oligopoly. Furthermore, if firms involved in cross-holding obtain a strategic advantage to be the leaders (i.e. Stackelberg leadership through cross-holding), such cross-holding will improve both consumer surplus and social welfare. We also discuss robustness of our main results with respect to convex costs and product differentiation.
A Rehabilitation of the Law of Diminishing Marginal Utility: An Ordinal Marginal Utility Approach
Authors: Lin Chung-Cheng , Peng Shi-Shu 
Published: July 2021

Abstract
The model in which an individual maximizes his ordinal or cardinal total utility has long been the paradigm of individual choice theory. However, the two mainstream utility theories, the ordinal and cardinal total utility theories, have caused a dilemma, i.e. one has to sacrifice one of the following two: the good property of utility ordinality, or common-sense notions such as the law of diminishing marginal utility. Ordinal theory keeps the former but gives up the latter, while cardinal theory keeps the latter but sacrifices the former. We propose an ordinal marginal utility approach aiming to solve this dilemma by changing the very first assumption regarding individual choice.
Variability and improvement of optical and antimicrobial performances for CQDs/mesoporous SiO2/Ag NPs composites via in situ synthesis
Authors: Cheng Youliang , Wang Mingjie , Fang Changqing , Wei Ying , Chen Jing , Zhang Jin 
Published: July 2021

Abstract
To change the optical properties and improve the antibacterial performances of carbon quantum dots (CQDs) and Ag NPs, mesoporous SiO2 spheres were combined with them to form the composites. In this paper, CQDs with a uniform size of about 3.74 nm were synthesized using glucose as carbon source. Then, CQDs/mesoporous SiO2/Ag NPs composites were obtained in situ under UV light irradiating by using mesoporous SiO2 and Ag NO3 as the carrier and silver resource, respectively. The diameter of CQDs/mesoporous SiO2/Ag NPs particles was in the range of 200–250 nm. With the increase in irradiating time, the red-shift in the UV-Vis spectrum for as-prepared CQDs/mesoporous SiO2/Ag NPs composites was found, and the adsorption peak was widened. In addition, the composites showed a high antibacterial activity against Staphylococcus aureus and Escherichia coli via disc diffusion method. These results indicated that inhibition circles for Ag NPs/mesoporous SiO2/CQDs and mesoporous SiO2/Ag NPs were similar in diameter. Furthermore, the two composites had a better bactericidal performance compared with other particles. Therefore, as-prepared CQDs/mesoporous SiO2/Ag NPs composites in this paper have great potential applications for fluorescent materials and antibacterial materials.
Green synthesis of silver nanoparticles: Characterization and its potential biomedical applications
Authors: Alwhibi Mona S. , Soliman Dina A. , Awad Manal A. , Alangery Asma B. , Al Dehaish Horiah , Alwasel Yasmeen A. 
Published: July 2021

Abstract
In recent times, research on the synthesis of noble metal nanoparticles (NPs) has developed rapidly and attracted considerable attention. The use of plant extracts is the preferred mode for the biological synthesis of NPs due to the presence of biologically active constituents. Aloe vera is a plant endowed with therapeutic benefits especially in skincare due to its unique curative properties. The present study focused on an environmental friendly and rapid method of phytosynthesis of silver nanoparticles (Ag-NPs) using A. vera gel extract as a reductant. The synthesized Ag-NPs were characterized by transmission electron microscopy (TEM), UV-Vis spectroscopy, Fourier transform infrared (FTIR), and dynamic light scattering (DLS). TEM micrographs showed spherical-shaped synthesized Ag-NPs with a diameter of 50–100 nm. The UV-Vis spectrum displayed a broad absorption peak of surface plasmon resonance (SPR) at 450 nm. The mean size and size distribution of the formed Ag-NPs were investigated using the DLS technique. Antibacterial studies revealed zones of inhibition by Ag-NPs of A. vera (9 and 7 mm) against Pseudomonas aeruginosa and Escherichia coli, respectively. Furthermore, the antifungal activity was screened, based on the diameter of the growth inhibition zone using the synthesized Ag-NPs for different fungal strains. Anticancer activity of the synthesized Ag-NPs against the mouse melanoma F10B16 cell line revealed 100% inhibition with Ag-NPs at a concentration of 100 µg mL−1. The phytosynthesized Ag-NPs demonstrated a marked antimicrobial activity and also exhibited a potent cytotoxic effect against mouse melanoma F10B16 cells. The key findings of this study indicate that synthesized Ag-NPs exhibit profound therapeutic activity and could be potentially ideal alternatives in medicinal applications.
Reading Stephen’s Speech as a Counter-Cultural Discourse on Migration and Dislocation
Authors: Hogeterp Albert L. A. 
Published: July 2021

Abstract
The speech of Stephen in Acts 7:2–53 contains a wealth of references to biblical migration narratives, but their significance for understanding the message of Luke–Acts has been understudied. This is partly due to a recurrent focus on either accusations against Stephen (Acts 6:8–15) or the polemical conclusion of the speech (Acts 7:47–50.51–53). It also partly relates to a teleological interest in early Christian mission narrative. This article reads Stephen’s speech as a counter-cultural discourse on migration and dislocation. It provides a close reading of its biblical story-telling in conjunction with its polemical upshot, and further compares Lucan narrative choices with early Jewish and Jewish Hellenistic literary cycles about patriarchal and Mosaic discourse. It applies a critical lens to the use of ancient narratives of migration and dislocation in discussions about identity, ethnicity, and “othering;” this is of further importance for contemporary identity politics around migration. Through comparing the speech with intra-Jewish dimensions and Graeco-Roman contexts, Stephen emerges as a counter-cultural speaker whose discourse appeals to human–divine intersectionality, specifically regarding the cause of justice for the ill-treated stranger; at the same time, it avoids cultural stereotyping through categories of Hebrews vs Hellenists, Jews vs Christians, Graeco-Roman elite standards vs supposedly “non-European” profiles.
Within-Trial Persistence of Learned Behavior as a Dissociable Behavioral Component in Hippocampus-Dependent Memory Tasks: A Potential Postlearning Role of Immature Neurons in the Adult Dentate Gyrus
Authors: Luchetti Alessandro , Yamaguchi (山口拓馬) Takuma , Uemura Masato , Yovianto Glen , Čulig Luka , Yang Ming , Zhou Wei , Oschmann Franziska , Lua MinFeng , Tashiro (田代　歩) Ayumu 
Published: July 2021

AbstractThe term “memory strength” generally refers to how well one remembers something. But more precisely it contains multiple modalities, such as how easily, how accurately, how confidently and how vividly we remember it. In human, these modalities of memory strength are dissociable. In this study, we asked whether we can isolate a behavioral component that is dissociable from others in hippocampus-dependent memory tasks in mice, which potentially reflect a modality of memory strength. Using a virus-mediated inducible method, we ablated immature neurons in the dentate gyrus in mice after we trained the mice with hippocampus-dependent memory tasks normally. In memory retrieval tests, these ablated mice initially showed intact performance. However, the ablated mice ceased learned behavior prematurely within a trial compared with control mice. In addition, the ablated mice showed shorter duration of individual episodes of learned behavior. Both affected behavioral measurements point to persistence of learned behavior. Thus, the effect of the postlearning manipulation showed dissociation between initial performance and persistence of learned behavior. These two behavioral components are likely to reflect different brain functions and be mediated by separate mechanisms, which might represent different modalities of memory strength. These simple dissociable measurements in widely used behavioral paradigms would be useful to understand detailed mechanisms underlying the expression of learned behavior and potentially different modalities of memory strength in mice. We also discuss a potential role that immature neurons in the dentate gyrus may play in persistence of learned behavior.
Action Costs Rapidly and Automatically Interfere with Reward-Based Decision-Making in a Reaching Task
Authors: Pierrieau Emeline , Lepage Jean-François , Bernier Pierre-Michel 
Published: July 2021

AbstractIt is widely assumed that we select actions we value the most. While the influence of rewards on decision-making has been extensively studied, evidence regarding the influence of motor costs is scarce. Specifically, how and when motor costs are integrated in the decision process is unclear. Twenty-two right-handed human participants performed a reward-based target selection task by reaching with their right arm toward one of two visual targets. Targets were positioned in different directions according to biomechanical preference, such that one target was systematically associated with a lower motor cost than the other. Only one of the two targets was rewarded, either in a congruent or incongruent manner with respect to the associated motor cost. A timed-response paradigm was used to manipulate participants’ reaction times (RT). Results showed that when the rewarded target carried the highest motor cost, movements produced at short RT (<350 ms) were deviated toward the other (i.e., non-rewarded, low-cost (LC) target). In this context participants needed an additional 150-ms delay to reach the same percentage of rewarded trials as when the LC target was rewarded. Crucially, motor costs affected the total earnings of participants. These results demonstrate a robust interference of motor costs in a simple reward-based decision-making task. They point to the rapid and automatic integration of motor costs at an early stage of processing, potentially through the direct modulation of competing action representations in parieto-frontal regions. The progressive overcoming of this bias with increasing RT is likely achieved through top-down signaling pertaining to expected rewards.
Over-the-counter protein supplement resulting in impaired thyroxine absorption in a hypothyroid patient
Authors: Kumarathunga P A D M , Kalupahana N S , Antonypillai C N 
Published: July 2021

Summary
Whey protein is a popular dietary supplement that is claimed to provide multiple health benefits. It has been shown to delay gastric emptying and impair ileal nutrient absorption. Additionally, some of the other additives like papain enzyme, soy lecithin in these protein supplements could interfere with L-thyroxine absorption. There is no evidence in the literature for the effects of protein supplements on L-thyroxine absorption. Herein, we describe a case of a 34-year-old lady who was on endocrinology follow up for primary hypothyroidism with stable thyroid-stimulating hormone (TSH) levels within the normal range while on L-thyroxine with a dose of 125 µg daily for the last 3 years, presenting with mild hypothyroid symptoms and elevated TSH level following a recent introduction of a protein supplement by her physical care adviser. Her treatment adherence and ingestion technique were good throughout, she was not on other medications or herbal remedies, there were no other changes in her food pattern or features suggestive of malabsorption, she was not pregnant, was taking the same L-thyroxine brand and TSH test was done from the routine lab. Since the only factor which could have contributed to the deranged TSH levels was the recent introduction of the whey protein supplement, we advised her to stop the protein supplement while continuing the same dose of L-thyroxine. Her TSH level was repeated in 6 weeks and was found to be normal (1.7 mIU/L). Our case report demonstrates that over-the-counter protein supplements could interfere with L-thyroxine absorption. Therefore, patients on L-thyroxine should be cautious when taking them.

Learning points

Over-the-counter protein supplements could interfere with oral L-thyroxine absorption.

The underlying mechanism could be the effect of whey protein by delaying gastric emptying and reduced responsiveness of organic anion transporters in the ileum, and there may be a contribution from other additives like papain and soy lecithin present in these supplements.

When there is an elevation of previously stable thyroid-stimulating hormone (TSH) value in a hypothyroid patient on oral L-thyroxine, the patient's assessment should include inquiring for a recent introduction of protein supplement, in the absence of other well-known risk factors.

Discontinuation of protein supplement results in normalization of thyroid function tests.

Patients on oral L-thyroxine should be cautious when taking over-the-counter protein supplementation.
MAIN TYPES OF AMERICAN SLANG AND ITS TRANSLATION INTO UKRAINIAN
Authors: Hurko Olena 
Published: July 2021

Background. Today, issues related to the study of slangisms are gaining new perspectives as slang is becoming an integral part of modern linguistics. Slangisms gradually become part of the language, function in it, and then disappear, giving opportunity new ones to exist (so new slang expressions can be formed). However, American slang is peculiar and unique, created in different social and age groups as a desire for brevity and expressiveness, sometimes as a protest against long words or as a desire to name an object or its properties in its own way. Therefore, considering the fact that linguistics of the 21st century is characterized by a tendency to analyze live communication, and oral language communication is still the most important aspect of language, we consider the study of American slang and the identification of its major groups to be relevant at the present stage of the development of linguistics and translation.Purpose. In our scientific study we aim to investigate the specifics of using American slangisms.Methods. In the context of studies, a descriptive method was used, which made it possible to theoretically generalize the results, systematize and interpret the functioning of slang units at a particular stage of language development, continuous sampling method was used to distinguish modern American slang units from the total number of lexemes as well as the method of translation transformations to achieve the adequate transmission of the content of these slangisms.Results. Scientists mainly distinguish two types of slang – general and special. However, there is currently no unanimity in distinguishing between special slang. Some researchers believe that special slang encompasses argo, kent, rhyming slang, social jargon and professional speeches, back slang. Others are convinced that special slang is a specific vocabulary and phraseology of social jargon, professional speeches, and the argo of the criminal world. However, in our opinion, special slang is basically a national phenomenon that has no analogues in another culture. Therefore, within our study we distinguish 4 types of slang: 1) rhyming slang; 2) mobile slang; 3) student slang; 4) everyday slang.Discussion. The issue of slang translation is one of the most difficult ones in translation theory. At the same time, it is important for any translator, because it is related to a number of elements, in particular, the translation variety of country studies, the culture of the translator, the availability of equivalents, context, education and knowledge of the translator. In our view, promising areas include the study of gender features in the use of American slang