bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physics-augmented deep learning for high-speed electromagnetic simulation and optimization
Authors: Chen Mingkun , Lupoiu Robert , Mao Chenkai , Huang Der-Han , Jiang Jiaqi , Lalanne Philippe , Fan Jonathan 
Published: August 2021

Abstract
The calculation of electromagnetic field distributions within structured media is central to the optimization and validation of photonic devices. We introduce WaveY-Net, a hybrid data- and physics-augmented convolutional neural network that can predict electromagnetic field distributions with ultra fast speeds and high accuracy for entire classes of dielectric photonic structures. This accuracy is achieved by training the neural network to learn only the magnetic near-field distributions of a system and to use a discrete formalism of Maxwell's equations in two ways: as physical constraints in the loss function and as a means to calculate the electric fields from the magnetic fields. As a model system, we construct a surrogate simulator for periodic silicon nanostructure arrays and show that the high speed simulator can be directly and effectively used in the local and global freeform optimization of metagratings. We anticipate that physics-augmented networks will serve as a viable Maxwell simulator replacement for many classes of photonic systems, transforming the way they are designed.
Incidence and Predictors of Fragility Fracture in Postmenopausal Rheumatoid Arthritis Patients Receiving Oral Bisphosphonates: A Longitudinal Observational Study
Authors: Kishimoto Yuji , Kato Yoshihiro , Uemura Manami , Kuranobu Koji 
Published: August 2021

Abstract
Background: Although many studies have reported the predictors of fractures in patients with rheumatoid arthritis (RA) who are not receiving anti-osteoporotic treatments or who are receiving unspecified treatments, studies focusing on the predictors of fracture in patients with RA who are currently being treated with oral bisphosphonates (BP) are quite scarce. This study aims to investigate the incidence and predictors of fragility fracture in postmenopausal patients with RA receiving oral BP.Methods: This retrospective longitudinal observational study comprised 98 postmenopausal RA patients receiving oral BP for a minimum of 6 months between April 2015 and December 2020. The cumulative incidence of fragility fractures including vertebral and nonvertebral fractures was investigated using the Kaplan–Meier method. Cox proportional hazards analysis was used to analyze baseline predictors of future fragility fractures. To determine a cutoff value of continuous predictors, the receiver-operating characteristic curve was applied.Results: Twenty patients developed fractures during the study period, with a cumulative incidence of 6.1% at 12 months, 10.5% at a median follow-up of 28 months, and 14.4% at 36 months. Multivariable Cox hazards analysis showed a history of prior vertebral fracture (hazard ratio [HR]: 6.26, 95% confidence interval [CI]: 1.99‒19.68, P = 0.001) and dose of methotrexate (HR: 0.87, 95% CI: 0.76‒0.99, P = 0.041) to be independent predictors. The cutoff value for methotrexate dose was 4 mg/week.Conclusions: We found a cumulative incidence of any fractures of 10.5% at 28 months in patients with RA currently being treated with oral BP. A history of prior vertebral fractures and methotrexate dose were positive and negative predictors for fractures, respectively. Practitioners should consider selecting another anti-osteoporotic drug in patients with RA who remain at risk despite receiving oral BP.
Seismic Fragility And Post-Earthquake Reparability of Concrete Frame With Low-Bond High-Strength Rebar Reinforced Concrete Column
Authors: Wang Junhua , Sun Y.P. 
Published: August 2021

Abstract
To further study the global seismic behaviour and post-earthquake reparability of RC building frames with the proposed self-centring columns with low-bond high-strength reinforcements (LBHSRs), incremental dynamic analysis (IDA) of five-floor and ten-floor frame archetypes under excitation by twenty ground motions (GMs) was performed. First, the pushover results indicated that the use of LBHSR could substantially improve the yield and ultimate lateral drift of both the archetypes, although the archetype had a smaller longitudinal reinforcement ratio (LR) of the LBHSR and similar seismic resistance. The dynamic response results indicated that the archetype with LBHSRs exhibited a smaller residual story lateral drift although the effectiveness of the use of LBHSR to reduce seismic response was not apparent for the archetype subjected to a low-intensity earthquake. The seismic fragility results showed that LBHSR was more effective for preventing seismic collapse than for attaining the immediate occupancy (IO), life safety (LS), and collapse prevention (CP) limit states. Furthermore, the higher the LR, the lower was the likelihood of seismic collapse. The fragility curves of the residual story lateral drifts indicate that the use of LBHSR can significantly mitigate the residual deformation in the DS1, DS2, and DS3 damage states. Moreover, the effectiveness increases with the increase in the LR and earthquake intensity. Comparisons of residual story lateral drifts between the predicted results and IDA results indicated that the present calculation models are not suitable for predicting residual deformation. The model needs to be studied further.
Community structure, distribution pattern, and influencing factors of soil Archaea in the construction area of a large-scale photovoltaic power station
Authors: Wu Wei , yuan bo , Yue Shengjuan , Zou Penghui , Yang Ruoting , Zhou Xiaode 
Published: August 2021

Abstract
The photovoltaic power station in Qinghai has been built for 8 years, however, its impact on the regional soil ecological environment has not been studied in depth. To reveal the structure and distribution pattern of archaeal communities in desert soil under the influence of a large photovoltaic power station, a comparative study was carried out between the soil affected by photovoltaic panels and the bare land samples outside the photovoltaic station in Gonghe, Qinghai Province. The abundance, community structure, diversity, and distribution characteristics of archaea were analyzed by quantitative PCR and Illumina-MiSeq high-throughput sequencing, and the main environmental factors affecting the variation of soil archaeal community were identified by RDA. The contribution rate of environmental factors and human factors to microbial community diversity was quantitatively evaluated by VPA. The results showed that there was no significant difference in soil nutrients and other physicochemical factors between the photovoltaic power station and bare land. Thaumarchaeota was the dominant archaeal phylum in the area, accounting for more than 99% of archaeal phylum, while at the level of genus, Nitrososphaera was the dominant archaeal genera. There was no significant difference in archaeal community structure between and under different types of PV panels. The analysis has shown that the construction of a photovoltaic station has little effect on the community structure of soil archaea in a desert area, and it was speculated that the selection of niche played a leading role in the distribution pattern of soil archaeal community. This study provides the basis for a scientific understanding of the characteristics and distribution patterns of soil archaeal communities affected by the construction of a photovoltaic power station.
The Study on the Construction Method of Bolting-Grouting Integrated Operation for Unmanned Arch Erection
Authors: Li Dewu , Lei Xiaotian , Zhang Guowei , Cao Mingxing 
Published: August 2021

Abstract
It is of great significance to improve the mechanization level and construction quality of tunnel construction. At present, large cross-section tunnels are emerging in China. The construction method based on manual work and supplemented by a machinery has long construction period, high labor intensity, and structural quality that cannot be guaranteed. To address those issues, this paper proposes the construction method of bolting-grouting integrated operation for an unmanned arch erection to achieve the rapid and safe construction of large section tunnels and reducing the amount of manual work. This paper mainly introduces the bolting-grouting integrated operation trolley, which can achieve the automatic installation of steel arch, the construction of locking anchor pipe, and shotcrete. Besides, this paper designs a new type of steel arch and an alternative way of longitudinal connecting reinforcement of steel arch. Moreover, with the field test and optimization adjustment of the Xinwushaoling tunnel, it is found that the construction method of bolting-grouting integrated operation for unmanned arch erection can overcome some disadvantages of traditional construction methods.
Interleukin 18, soluble cluster of differentiation 40, platelet factor 4 variant 1, and neutrophil gelatinase-associated lipocalin can be used as biomarkers to aid activity and diagnosis in ocular Behçet’s disease
Authors: Celik Fatih , Coteli Ebru , Gul Fatih Cem , Ozsoy Ercan , Kobat Sabiha Gungor , Akkoc Ramazan Fazil , Yardim Meltem , Sahin İbrahim , Yalcin Mehmet Hanifi , AYDIN SÜLEYMAN 
Published: August 2021

Abstract
Purpose
The molecules human interleukin (IL-18), the soluble cluster of differentiation (sCD40), platelet factor 4 variant 1 (PF4V1), and neutrophil gelatinase-associated lipocalin (NGAL) are all markers of inflammation in biological systems and are linked to prognosis in several inflammatory diseases as well. Since there is no study in which the above-mentioned molecules are studied together in ocular Behçet's disease (OBD), the aim of this study is to reveal whether these molecules are activity markers in active (OABD) and inactive (OIBD) disease.
Methods
30 OABD and 30 OIBD and 30 healthy individuals were included in the study. IL-18, sCD40, PF4V1, and NGAL molecules were studied in blood samples by the ELISA method.
Results
When OABD and OIBD were compared to healthy individuals, the levels of IL-18, sCD40, PF4V1, and NGAL molecules were found to be statistically significant. These values were even more significantly higher in patients with OABD.
Conclusion
When ROC values of IL-18, sCD40, PF4V1, and NGAL are evaluated, it is clear that these four molecules can be used as biomarkers to aid activity and diagnosis in OBD.
Experimental Study on Creep Properties Prediction of Reed Bales Based on SVR and MLP
Authors: Li Jixia , Zhang Lixin , Huang Guangdi , Wang Huan , Jiang Youzhong 
Published: August 2021

Abstract
Background: Reed has high lignin content, wide distribution and low cost. It is an ideal raw material for replacing wood in the paper industry. Reeds are rich in resources, but the density of reeds is low, leading to high transportation and storage costs. This paper aims to study the compression process of reeds and the creep behaviour of compressed reeds, and provide theoretical guidance for the reed compressor management, bundling equipment and the stability of compressed reed bales.Results: We studied the strain-time relationship and strain of the reed bales compressed under constant force and the creep behaviour of the reed bales under different holding forces. Additionally, the creep behaviour of reed bales under various retention forces was investigated. The test curves are fitted by Machine Learning Prediction Algorithms and Support Vector Machine Regression. And use machine learning prediction algorithm model to establish a quaternary model of reed creep. The results show that the creep behaviour of a reed bale was positively correlated with the initial maximum compressive stress. The established Burgers four-element model was capable of simulating the creep process of reed bales. The test curves coincided well with the model-simulated curves. Reed bales were found to exhibit viscoelasticity. During the creep process, the elastic dynamic force and the viscous resistance were mutually constrained. The strain of reeds was composed of elastic, viscoelastic and plastic εs. And elaborated the three stages of the creep process in detail.Conclusions: We studied the relationship between the strain and time of the reed and the strain and creep behaviour of the reed bag under different holding forces under constant force. It is proved that the multi-layer perceptron network is better than the support vector machine regression in predicting the characteristics of reed materials. The three stages of elasticity, viscoelasticity and plasticity in the process of reed creep are analysed in detail. This article opens up a new way for using machine learning methods to predict the mechanical properties of materials. The proposed prediction model provides new ideas for the characterization of material characteristics.
A Qualitative Quasi-experimental Evaluation of Using 3D Computer Visualization to Support User Participation in Architectural Design Process
Authors: Saleh Ahmad , Rafi Ahmad , Woods Peter 
Published: August 2021

Abstract
This article evaluates the use of three-dimensional (3D) computer visualization (CV) media against two-dimensional (2D) traditional visualization (TV) media, to support the participation of users at the early stage of the architectural design process, based on a qualitative quasi-experimental approach. As a strategic qualitative approach, a conversational dialogue between an architect and twelve clients was used to assess the participation behavior of the clients in designing their houses by using two different versions of media in experimental design conditions. Results have revealed that the qualitative quasi-experiment was convenient to distinguish the various kinds of media influencing the interaction and information exchange between architects and clients. 3D CV was more helpful in stimulating more information and ideas through the conversation process.
Different Electrical Properties of Paraspinal Muscle in Young Adults With Non-specific Chronic Low Back Pain and Healthy Individuals by Electrical Impedance Myography: A Cross-sectional Study
Authors: Wang Hongjiang , Yu Qiuhua , Fan Ziyan , Zheng Jiaxuan , Lo Wai Leung Ambrose , Li Le , Wang Chuhuai 
Published: August 2021

Abstract
BackgroundNon-specific chronic low back pain (NSCLBP) is a multifactor disorder with high prevalence rate of people all around the world. Lumbar paraspinal muscle (LPM) plays an important role of spine stabilization. However, the electrical properties of LPM in the patients were unclear. Aim to explore the electrical properties of bilateral LPM between patients with NSCLBP and healthy controls (HC), the study was designed to applied electrical impedance myography (EIM) technique to measure the LPM.MethodsA total of thirty participates (15 in NSCLBP group, 15 in HC group) were instructed to have each side of LPM measured at the rest state and the maximum volunteer contraction (MVC) state. Then measured the EIM parameters of LPM at L4/5 level by a multi-frequency device. Each measurement repeated three times. The EIM parameters at 50 kHz, 100 kHz, 200 kHz current frequencies were enrolled into the statistical analysis.ResultsAt the three current frequencies, parameters in the right side of LPM had not significantly difference from the left (P>0.05, respectively). Resistance (R) of LPM in NSCLBP group was larger than that in HC group (P<0.05, respectively), phase angle (PA) in NSCLBP group was smaller than that in HC group (P<0.05, respectively) and there was no difference of the reactance value between the two groups (P>0.05, respectively). At 50 kHz, relationships between the EIM parameters and geometric parameters of LPM were not significant in NSCLBP group or HC group (P>0.05, respectively).ConclusionThe electrical properties of bilateral LPM in young adults with NSCLBP were different from those of healthy individuals regardless of any current frequency. The ultrasound parameters of LPM, however, showed no significant difference between young patients with NSCLBP and healthy participants. EIM measurement might be more sensitive than rehabilitative ultrasound for NSCLBP in young adults.Trial registrationThe Chinese Clinical trial registration number: ChiCTR2100043113.
Sensitivity of Pipistrellus Nathusii Kidney Diploid Cell Strain to Viruses of Rhabdoviridae, Reoviridae, Bunyaviridae and Paramixoviridae Families
Authors: Povolyaeva Olga , Chadaeva Anna , Sindryakova Irina , Lapteva Oksana , Yurkov Sergey 
Published: August 2021

Abstract
The discovery of a significant number of viral pathogens in bat tissue samples and excrement point to a potential prominent role of chiropters in the maintenance and spread of human and animal diseases. It also indicates the potential sensitivity of bat cells to a broad spectrum of viruses. The migratory pipistrelle bat, Pipistrellus nathusii, inhabits northeastern Europe and typically migrates to the southwest. Our study revealed the sensitivity (susceptibility) of a diploid cell line, derived from the kidney of P. nathusii to several transmissible animal disease causative agents such as Epizootic hemorrhagic disease, Akabane disease, Vesicular stomatitis virus and Peste des petit ruminants. High sensitivity of the P. nathusii kidney diploid cell line to viruses from various taxonomic groups allows them to be recommend for extensive use in virological studies.
High Expression of TRIM24 Predicts Worse Prognosis And Promotes Proliferation And Metastasis of Epithelial Ovarian Cancer
Authors: Zhang Liwei , Chen Hong , Ding Baijuan , Jiang Wei 
Published: August 2021

Abstract
Background: Tripartite Motif-Containing 24 (TRIM24) is a member of the tripartite motif family. TRIM24 is claimed aberrantly activated in a number of cancers, such as breast cancer, prostate cancer and lung cancer. However, the expression of TRIM24 in epithelial ovarian cancer (EOC) and its relationship with prognosis remain unclear. In this study, we investigated the expression pattern and underlying clinical significance of TRIM24 in ovarian cancer.Results: Data from Oncomine and immunohistochemistry of tissue samples demonstrated that TRIM24 expression was obviously elevated in ovarian carcinoma compared with normal ovary tissues. Elevated TRIM24 expression was closely correlated with serum CA-125 (P = 0.0294), metastasis (P = 0.0022), FIGO (International Federation of Gynecology and Obstetrics) stage (P = 0.0068) and Ki-67 level (P = 0.0395). Kaplan-Meier survival analysis found that TRIM24 expression increased inversely with the clinical prognosis of patients with EOC. Moreover, colony formation and CCK-8 assays showed that TRIM24 promoted ovarian cancer cell growth, and tumorigenic experiments in nude mice showed that TRIM24 knockdown inhibited tumor growth in vivo. The Spearman’s correlations revealed that the expression of TRIM24 was significantly correlated with levels of Ki-67 (P = 0.01), at a correlation coefficient of 0.517. Wound-healing and transwell migration assays demonstrated TRIM24 facilitated cell migration. Mechanism studies showed that TRIM24 could promote the phosphorylation level of Akt and the process of EMT.Conclusion: Our results confirmed that TRIM24 could predict poor prognosis of EOC patients and promote tumor progression by regulating Akt pathway and EMT. TRIM24 may be used as a new prognostic marker for EOC and may provide a new strategy for targeted therapy of epithelial ovarian cancer.
Tailoring Nanocomposite Membranes of Cellulose of Acetate/Silica Nanoparticles for Desalination
Authors: Ali Amira S. Mohammed , Soliman Moataz M. , Kandil Sherif H. , Ebrahim Shaker , Khalil Marwa 
Published: August 2021

Abstract
Herein, fabrication of cellulose acetate (CA) silica-based nanocomposite membranes via the dry-wet phase inversion procedure for the water desalination was investigated. The modified and unmodified silica nanoparticles (SNPs and MSNPs) were prepared by the sol-gel technique. The addition effect of the SNPs and MSNPs was investigated on the CA membranes properties and their performance for water separation. The CA nanocomposite membranes were characterized to study their structure, hydrophilicity, and morphology. The fabricated nanocomposite membranes showed hydrophilic surface properties. The performance of reverse osmosis (RO) membranes was measured using a crossflow RO unit. At 10 bar, The membrane with 10 mg of SNPs showed enhanced permeate water flux compared to the pristine CA membrane by 1.6 L/m 2 .hr. Increasing the SNPs in the nanocomposite membrane showed enhancement in the permeate water flux all over the operating pressure. The effect of MSNPs on the nanocomposites’ performance was lower than their counterpart in the case of adding SNPs. The membrane with 30 mg of MSNPs showed the highest permeate water flux among other nanocomposite membranes with a value of 35.7 L/m 2 .hr at 24 bar.
Ovarian Tissue Cryopreservation in a Patient with Breast Cancer During Pregnancy: A Case Report
Authors: Cheng Jiaojiao , Ruan Xiangyan , Du Juan , Jin Fengyu , Li Yanglu , Liu Xiaowei , Wang Husheng , Gu Muqing , Mueck Alfred O. 
Published: August 2021

Abstract
Background: Fertility preservation using ovarian tissue cryopreservation (OTC) in patients with certain diseases especially needing chemo- or radiotherapy is becoming a routine management in various Western countries. Our hospital is the first and until now the only center in China using this method. The question is controversial, if treatment of breast cancer during pregnancy (PrBC) should be similar like for non-pregnant young patients with breast cancer. To our knowledge this worldwide is the first report using OTC as fertility preservation for PrBC. Case presentation: During the 29th week of the pregnancy of a 24-year-old woman needle aspiration cytology of a left breast tumor showed cancer cells. The ultrasound revealed BI-RADS 4a grade. Oncologists recommended the termination of pregnancy. Cesarean section at week 32 was performed, and ovarian tissue samples were collected for OTC to preserve fertility and ovarian endocrine function. Twenty-three ovarian cortex slices were slowly programmed cryopreserved. It is estimated that 13000 follicles have been cryopreserved. Breast nodules and sentinel lymph node biopsy suggested invasive micropapillary carcinoma. Neoadjuvant chemotherapy within 1 week after diagnosis was started. After six courses of neoadjuvant chemotherapy, targeted drug therapy, and Goselin acetate, left mastectomy and left axillary lymph node dissection were performed. In total twenty-three times of radiotherapy, eight trastuzumab targeted therapy, and 17 pertuzumab + trastuzumab double targeted therapy was performed after breast cancer surgery. Until now, more than two years after delivery the ovarian function still is good. We do not see any signs of a negative impact of OTC. The injections of goserelin acetate, every 28 days, are planned to last for the next five years. In addition endocrine therapy with anastrozole, started after the breast cancer surgery, also is scheduled for five years. Conclusion: OTC for fertility preservation in patients with PrBC does not delay breast surgery, radiotherapy, or chemotherapy which is essential for an effective treatment of breast cancer. We assess this method as a promising fertility preservation method, worldwide for the first time now also used in a patient getting breast cancer in pregnancy.