bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Adiposity and Energy Balance After Normotensive and Preeclamptic Pregnancies
Authors: McLennan Sarah L , Henry Amanda , Roberts Lynne M , Siritharan Sai S , Ojurovic Melissa , Yao Amanda , Davis Gregory K , Mangos George , Pettit Franziska , Brown Mark A , O’Sullivan Anthony J 
Published: April 2021

Abstract

Background
Preeclampsia is a major pregnancy complication associated with long-term maternal cardiometabolic disease. Research generally is focused on metabolic and pathophysiological changes during pregnancy; however, there is much less focus on the early postpartum period in subjects who suffered preeclampsia. The aim of this study was to (1) characterize energy intake and expenditure 6 months following normotensive and preeclamptic pregnancies and (2) examine associations between energy balance, body composition, insulin resistance measures (HOMA-IR), and clinical characteristics.

Design
A cross-sectional study 6 months following normotensive (n = 75) and preeclamptic (n = 22) pregnancies was performed. Metabolic measurements included anthropometrics measures, body composition via bioelectrical impedance analysis, 24-h energy expenditure via SenseWear Armbands, energy intake via a 3-day food diary, and serum metabolic parameters.

Results
Six months following preeclampsia, women had a significantly higher weight (77.3 ± 20.9 kg vs 64.5 ± 11.4 kg, P = 0.01), fat mass percentage (FM%; 40.7 ± 7.4% vs 34.9 ± 8.1%, P = 0.004), and insulin resistance (HOMA-IR 2.2 ± 1.5 vs 1.0 ± 0.7, P = 0.003), as well as reduced HDL levels (1.5 ± 0.4 mmol/L vs 1.8 ± 0.4 mmol/L, P = 0.01) compared to normotensive women. Women post-preeclampsia had lower activity-related energy expenditure (P = 0.02) but a decreased total energy intake (P = 0.02), leading to a more negative energy balance compared to their normotensive counterparts (−1942 kJ/24 h vs −480 kJ/24 h, P = 0.02).

Conclusion
Increases in insulin resistance and FM%, reduced high-density lipoprotein, and more sedentary lifestyles characterize the postpartum period following preeclamptic compared with normotensive pregnancies. Early post-preeclampsia interventions, such as lifestyle behavior change, should be implemented and assessed to determine whether they reduce long-term cardiometabolic risk in women who experienced preeclampsia during pregnancy.
Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHB
Authors: Bohaczuk Stephanie C , Cassin Jessica , Slaiwa Theresa I , Thackray Varykina G , Mellon Pamela L 
Published: April 2021

Abstract
FSH is critical for fertility. Transcription of FSHB, the gene encoding the beta subunit, is rate-limiting in FSH production and is regulated by both GnRH and activin. Activin signals through SMAD transcription factors. Although the mechanisms and importance of activin signaling in mouse Fshb transcription are well-established, activin regulation of human FSHB is less well understood. We previously reported a novel enhancer of FSHB that contains a fertility-associated single nucleotide polymorphism (rs10031006) and requires a region resembling a full (8 base-pair) SMAD binding element (SBE). Here, we investigated the role of the putative SBE within the enhancer in activin and GnRH regulation of FSHB. In mouse gonadotrope-derived LβT2 cells, the upstream enhancer potentiated activin induction of both the human and mouse FSHB proximal promoters and conferred activin responsiveness to a minimal promoter. Activin induction of the enhancer required the SBE and was blocked by the inhibitory SMAD7, confirming involvement of the classical SMAD signaling pathway. GnRH induction of FSHB was also potentiated by the enhancer and dependent on the SBE, consistent with known activin/GnRH synergy regulating FSHB transcription. In DNA pull-down, the enhancer SBE bound SMAD4, and chromatin immunoprecipitation demonstrated SMAD4 enrichment at the enhancer in native chromatin. Combined activin/GnRH treatment elevated levels of the active transcriptional histone marker, histone 3 lysine 27 acetylation, at the enhancer. Overall, this study indicates that the enhancer is directly targeted by activin signaling and identifies a novel, evolutionarily conserved mechanism by which activin and GnRH can regulate FSHB transcription.
Regulation of Pancreatic β-Cell Function by the NPY System
Authors: Yang Chieh-Hsin , Onda Danise-Ann , Oakhill Jonathan S , Scott John W , Galic Sandra , Loh Kim 
Published: April 2021

Abstract
The neuropeptide Y (NPY) system has been recognized as one of the most critical molecules in the regulation of energy homeostasis and glucose metabolism. Abnormal levels of NPY have been shown to contribute to the development of metabolic disorders including obesity, cardiovascular diseases, and diabetes. NPY centrally promotes feeding and reduces energy expenditure, while the other family members, peptide YY (PYY) and pancreatic polypeptide (PP), mediate satiety. New evidence has uncovered additional functions for these peptides that go beyond energy expenditure and appetite regulation, indicating a more extensive function in controlling other physiological functions. In this review, we will discuss the role of the NPY system in the regulation of pancreatic β-cell function and its therapeutic implications for diabetes.
OB-MECC: An Efficient Confidentiality and Security Enhancement for Cloud Storage System
Authors: NagaRaju P. , Nagamalleswara Rao N. 
Published: April 2021

Cloud computing (CC) is one amongst the developing technologies, which get more attention from academia as well as industries. It offers diverse benefits like sharing computing resources, service flexibility, reducing costs, etc. The Cloud Services Provider (CSP) is accountable for the data that are delivered to the cloud. The threat of seeing the stored data and using sensitive raw data by strangers is the main barrier in the utilization of cloud services. So, Data Security (DS) along with privacy is the chief issue, which is an obstacle while adopting the CC. Countless techniques are existent for ensuring data confidentiality, but they do not completely give protection to the data. To trounce these drawbacks, this paper introduces the Obfuscation (OB) based Modified Elliptical Curve Cryptography (MECC) algorithm for protecting data as of malicious attacks, which is termed as OB-MECC. Primarily, the proposed method obfuscates the data before they are uploaded to the cloud. For the OB of the data, the proposed work employs methods like substitution cipher (SC), position update, Ceaser cipher, binary conversion, 8-bit binary conversion, decimal(), two complex(), and ASCII(). Then, encryption of the obfuscated data is done with the utilization of the MECC algorithm. After encryption, the data on the cloud is retrieved. The retrieved data is then decrypted by reversing the OB and encryption process to get the actual data. The outcomes corroborate that the confidentiality and security level are maximum for the proposed OB-MECC when contrasted to the existing approaches.
Suspicious Action Detection in Intelligent Surveillance System Using Action Attribute Modelling
Authors: Mudgal Manisha , Punj Deepika , Pillai Anuradha 
Published: April 2021

Research in the field of image processing and computer vision for recognition of suspicious activity is growing actively. Surveillance systems play a key role in monitoring of sensitive places such as airports, railway stations, shopping complexes, roads, parking areas, roads, banks. For a human it is very difficult to monitor surveillance videos continually, therefore a smart and intelligent system is required that can do real time monitoring of all activities and can categories between usual and some abnormal activities. In this paper many different abnormal activities has been discussed. More focuses is given to violence activity like hitting, slapping, punching etc. For this large human action dataset like UCF101, Kaggel is required. This paper proposes a method to model violence actions using Gaussian Mixture Model with Universal Attribute Model. In this action vector is used to remove redundant attributes and get a low dimensional relevant action vectors.
Aspectos éticos y legales de los test de portadores de mutaciones recesivas en tratamientos de reproducción humana asistida con gametos donados
Authors: Reguera Cabezas Marta 
Published: April 2021

La contribución de donantes, necesaria en numerosos tratamientos de reproducción asistida, exige la aplicación de protocolos que garanticen la compatibilidad y seguridad en la selección y aplicación de dichas donaciones. Este trabajo analiza algunos aspectos relacionados con los avances tecnológicos que permiten detectar mutaciones para enfermedades recesivas, abriendo la posibilidad a la comparación genética (matching) entre donantes y receptores, reduciendo los riesgos de enfermedades transmisibles a la descendencia. Observando los límites que plantea esta tecnología, especialmente, el marco jurídico que rige la obligatoriedad o no de su utilización, así como la intervención de la autonomía del paciente receptor de dichos gametos. Poniendo de manifiesto la importancia del abordaje interdisciplinar y normativo ante la expansión de estos avances en reproducción asistida.
Correlation between Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score and Hemophilia Joint Health Score (HJHS) in patients with hemophilic arthropathy
Authors: Prasetyo Marcel , Moniqa Ratna , Tulaar Angela , Prihartono Joedo , Setiawan Stefanus Imanuel 
Published: April 2021

Background
Hemophilic arthropathy, a condition manifested as joint destruction due to spontaneous joint bleeding, is one complication of hemophiliac patients. Early detection and intervention may improve the outcome, in which ultrasonography can be an ideal modality with the introduction of HEAD-US (Hemophilia Early Arthropathy Detection with Ultrasound) protocol. Studies have shown US benefit in hemophiliac patients, including its potential as an alternative for the Hemophiliac Joint Health Score (HJHS) system. However, many of the studies were conducted in countries with better management of hemophilia using prophylaxis treatment. It is unclear whether HEAD-US has a correlation with HJHS in countries using episodic treatment only, like in Indonesia.

Purpose
This study aimed to explore the correlation between HEAD-US and HJHS in hemophiliac patients with joint problems in Indonesia.

Materials and methods
A cross-sectional correlation study between HEAD-US and HJHS was performed with primary data collected from 120 hemophilic patients. US examination was performed on elbow, knee and ankle joints using the HEAD-US scoring method by a musculoskeletal radiologist. HJHS examination was conducted by a trained physiotherapist and a medical rehabilitation specialist. All examiner is member of multidisciplinary Hemophiliac Management Team in Cipto Mangunkusumo General Hospital in Jakarta, Indonesia.

Results
The mean age of the participant was 9.3 (5–14) years old. The median score of HEAD-US was 8 (1–28) with most of the joint abnormalities found on the ankles. The median score of HJHS was 3 (0–35), with most joint abnormalities found on the knees. There was a moderate correlation between HEAD-US and HJHS score (p < 0.05, r = 0.65).

Conclusion
HEAD-US shows a moderate correlation to HJHS in hemophiliac patients who received episodic treatment. HEAD-US can provide additional value in the anatomical evaluation of the joint and could be complementary to HJHS in assessing the joint status in hemophilic patient
Increased Gene Copy Number of DEFA1A3 Is Associated With the Severity of Ulcerative Colitis
Authors: Kanmura Shuji , Morinaga Yuko , Tanaka Akihito , Komaki Yuga , Iwaya Hiromichi , Kumagai Kotaro , Mawatari Seiichi , Sasaki Fumisato , Tanoue Shiroh , Hashimoto Shinichi , Sameshima Yoichi , Ono Yohei , Ohi Hidehisa , Ido Akio 
Published: April 2021

INTRODUCTION:

DEFA1A3 encodes human neutrophil peptides (HNPs) 1–3 and has multiple copy number variations (CNVs). HNPs are associated with innate immunity. Ulcerative colitis (UC), a chronic inflammatory gastrointestinal disorder, is a life-threatening condition, and predictive markers of UC severity are needed. This study investigated the relationship between DEFA1A3 CNV and UC severity.

METHODS:
This study enrolled 165 patients with UC. The relationship between DEFA1A3 CNV and disease severity was analyzed based on Mayo score, patient characteristics, and treatment methods. In addition, serum and stimulated neutrophil-derived HNP concentrations were also measured in patients with high and low DEFA1A3 CNV.

RESULTS:

DEFA1A3 CNV was significantly correlated with Mayo score and white blood cell count (R = 0.46, P < 0.0001; R = 0.29, P = 0.003, respectively), and only high copy numbers of DEFA1A3 were independent factors for severe UC (P < 0.001, odds ratio: 1.88, 95% confidence interval, 1.34–2.61). The number of severe UC patients with high DEFA1A3 CNV was significantly greater than those with low CNV. We confirmed the associations between DEFA1A3 and UC severity using a validation cohort. In addition, the HNP concentration in high-copy number patients was significantly higher after neutrophil stimulation than that in low-copy number patients.

DISCUSSION:
This study demonstrated that there is a correlation between DEFA1A3 copy number and severity in patients with UC. In addition, neutrophils from UC patients with higher DEFA1A3 CNV had high reactivity of secretion of HNPs after stimulation. DEFA1A3 CNV may be a novel severity marker and a potential therapeutic target for UC.
Identification of High-Risk Patients With Nonalcoholic Fatty Liver Disease Using Noninvasive Tests From Primary Care and Endocrinology Real-World Practices
Authors: Younossi Zobair M. , Pham Huong , Felix Sean , Stepanova Maria , Jeffers Thomas , Younossi Elena , Allawi Hussain , Lam Brian , Cable Rebecca , Afendy Mariam , Younoszai Zahra , Afendy Arian , Rafiq Nila , Alzubaidi Nahrain , Ousman Yasser , Bailey Marc , Chris Zik , Castillo-Catoni Maria , Fozdar Pratima , Ramirez Maria , Husain Mehreen , Hudson Evis , Schneider Ingrid , Golabi Pegah , Nader Fatema 
Published: April 2021

INTRODUCTION:
We aimed to identify high-risk nonalcoholic fatty liver disease (NAFLD) patients seen at the primary care and endocrinology practices and link them to gastrohepatology care.

METHODS:
Using the electronic health record, patients who either had the diagnosis of type 2 diabetes or had 2 of 3 other metabolic risk factors met criteria for inclusion in the study. Using noninvasive fibrosis tests (NITs) to identify high risk of fibrosis, patients who met the NIT prespecified criteria were referred to gastrohepatology for clinical assessment and transient elastography.

RESULTS:
From 7,555 patients initially screened, 1707 (22.6%) met the inclusion criteria, 716 (42%) agreed to enroll, and 184 (25.7%) met the prespecified NIT criteria and eligibility for linkage to GE-HEP where 103 patients (68 ± 9 years of age, 50% men, 56% white) agreed to undergo linkage assessments. Their NIT scores were APRI of 0.38 ± 0.24, FIB-4 of 1.98 ± 0.87, and NAFLD Fibrosis Score of 0.36 ± 1.03; 68 (66%) linked patients had controlled attenuation parameter >248 dB/m, 62 (60%) had liver stiffness <6 kPa, and 8 (8%) had liver stiffness >12 kPa. Liver stiffness for the overall group was 6.7 ± 4.2 kPa, controlled attenuation parameter 282 ± 64 dB/m, and FAST score 0.22 ± 0.22. Linked patients with presumed advanced fibrosis had significantly higher body mass index (36.4 ± 6.6 vs 31.2 ± 6.4 kg/m2, P = 0.025) and higher NIT scores (APRI 0.89 ± 0.52 vs 0.33 ± 0.14, FIB-4 3.21 ± 2.06 vs 1.88 ± 0.60, and NAFLD Fibrosis Score 1.58 ± 1.33 vs 0.25 ± 0.94).

DISCUSSION:
By applying a simple prespecified multistep algorithm using electronic health record with clinical risk factors and NITs followed by transient elastography, patients with nonalcoholic fatty liver disease seen in PCP and ENDO practices can be easily identified.
A multimodal approach to intraoperative neuromonitoring of the spinal cord during spinal deformity correction
Authors: Buzunov A. V. , Vasyura A. S. , Dolotin D. N. , Sergunin A. Yu. , Novikov V. V. 
Published: April 2021

Objective. To analyze the results of a multimodal approach in intraoperative neurophysiological monitoring during surgical correction of spinal deformities.Material and Methods. The paper describes a variant of intraoperative neurophysiological monitoring of the spinal cord and nerve root functions which was used in the correction of scoliotic deformity of the spine in 138 patients. Surgery was performed in 83 patients aged 10 to 17 years and in 55 patients older than 17 years. The average age of patients was 20.23 ± 8.3 years. There were 41 male and 97 female patients. The primary scoliotic curve was localized in the thoracic spine in 90 cases, in the thoracolumbar spine in 27 cases, and in the lumbar spine in 21 cases.Results. In the early postoperative period, two patients developed neurological deficit, the electrophysiological predictors of which were recorded during intraoperative neurophysiological monitoring. In one case, the deficit gradually regressed completely due to the measures taken by the operating team during surgery; in the second case, a persistent neurological deficit in the form of lower paraplegia persisted, despite the measures taken during the surgical treatment. In other cases, intraoperative neurophysiological monitoring did not reveal any changes in the spinal cord and nerve roots, which in the early postoperative period would lead to the appearance or aggravation of motor deficit.Conclusion. A multimodal approach to intraoperative neurophysiological monitoring provides an operating surgeon with an objective assessment of the state of the spinal cord and nerve roots at any stage of surgery, which allows timely identification and elimination of the causes of their damage, thereby reducing the likelihood of neurological deficit development or aggravation in the postoperative period.
Cervical intervertebral disc denervation during rotator cuff tendon plasty
Authors: Peleganchuk A. V. , Leonova O. N. , Alekperov A. A. 
Published: April 2021

Objective. To analyze the effect of denervation of intervertebral discs in the cervical spine on the results of surgical treatment of patients with injuries to rotator cuff tendons of the shoulder joint.Material and Methods. Study design: descriptive hypothesis-generating study. The study included patients requiring surgical treatment of rotator cuff tear. Two groups were identified: Group A included 28 patients who underwent plastic repair of rotator cuff tear with additional denervation of intervertebral discs, and Group B – 30 patients who underwent only plastic surgery for rotator cuff tear. The intensity of pain according to the VAS, functional activity due to neck pain (NDI), functionality of the shoulder joint (UCLA), and the degree of intervertebral disc degeneration according to MRI were assessed, and the effectiveness of treatment was determined. Statistical calculations were performed using the RStudio program.Results. In the group of patients with denervation of intervertebral discs, a more pronounced decrease in the intensity of pain syndrome at 3, 6, and 12 months (p < 0.001; p < 0.001; and p = 0.002), a more proportion of effectively treated patients at 3 months (p = 0.003), and significant increase in functional activity according to NDI at 3, 6 and 12 months of follow-up period (p < 0.001; p = 0.010; and p = 0.045) were observed.Conclusions. There is an underestimation of the role of degenerative cervical spine pathology in the occurrence of shoulder joint pain. In the case of rotation cuff plasty the additional denervation reduces the intensity of pain syndrome in the shoulder joint in the postoperative period.
Posterior approach to ventrally and dorsally located spinal meningiomas
Authors: Grygoriev G. B. , Cherebillo V. Yu. , Goranchuk D. V. 
Published: April 2021

Objective. To analyze the outcomes of posterior approach in the surgery of intradural extramedullary meningiomas located ventrally and dorsally in relation to the spinal cord denticulate ligaments.Material and Methods. The study included 29 patients with spinal intradural meningiomas operated on using posterior approach. Patients were divided depending on the tumor location relative to the denticulate ligaments into ventral (n = 13) and dorsal (n = 16) groups. The surgery duration, the degree of tumor resection, clinical outcomes, the presence and nature of complications, and the frequency of recurrence were assessed.Results. The average follow-up period was 29 (6 to 61) months. Total tumor removal was performed in 93.1 % of cases: 11 cases (84.6 %) in ventral group and 16 cases (100.0 %) in dorsal group. The average duration of surgery was 136 minutes for dorsal meningiomas and 181 minutes for ventral meningiomas (p < 0.05). Complications in the form of CSF leakage were registered in two patients (6.9 %). In 11 (84.6 %) patients with ventral meningiomas and 15 (93.7 %) patients with dorsal meningiomas, an improvement or preservation of neurological functions at the pre-surgery level was observed. Recurrences were observed in two patients (6.9 %).Conclusion. Patients with spinal meningiomas have a favorable neurological outcome and a low recurrence rate. Surgery is more complicated in patients with ventral meningiomas. In most cases, unilateral posterior approach is applicable for both ventral and dorsal meningiomas.
Spine surgery in children: past, present and future
Authors: Dubousset J. 
Published: April 2021

In accordance with almost 55 years of experience in pediatric spine surgery, it is easy for me to describe the evolution of surgical technique, as well as indications for surgical interventions that were initially performed without the use of any instrumentation (which now are still occasionally considered as useful) through the anterior and posterior approaches, and with postoperative immobilization with plaster braces. The first types of really effective instrumentations were created sequentially by Harrington and Luque, and in parallel with their development, the pedicle screws (Roy-Camille) were introduced into practice. We had to wait another 20 years before the segmental 3D strategy and CD instrumentation appeared, which remain the basis of modern spinal technologies to this day, regardless of the type of anchoring elements (hooks, screws, universal clamps or hybrid structures). For the present and the future, early interventions remain indicated for local pathological foci, which are usually the result of congenital anomalies with or without spinal cord compression. But for extended deformities, especially of thoracic localization, plaster and removable braces remain a good choice, regardless of the etiology and the presence or absence of pelvic tilt. When such methods did not give the desired result, a lot of efforts were made using various technologies to preserve the growth potentials of the spinal column without impairing respiratory function. At the same time, it was obvious that the incidence of complications was high, and the need for a final fusion was often stated. Hence the emergence of bipolar minimally invasive technologies with very promising results and significant number of patients who developed a spontaneous bone block, made the fusion surgery meaningless. As for older children and adolescents, the race to achieve maximum Cobb angle correction is becoming more controversial. It has been convincingly shown that it is much more important for the future, from the point of view of spinal function, to achieve 3D dynamic balance, which is determined by intervertebral discs located cranial and caudal to the area of surgical fusion.