bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of Initial Developments Between Explosive and Ordinary Mid-latitude Cyclones Off the East Asian Coast in Winter
Authors: Gao Xiaoyu , Lu Ping , Hu Yang , Zhang Shuqin , Sun Xiaoyan , Zhang Qiuyang 
Published: December 2021

Abstract
Explosive cyclones (ECs) off the East Asian coast post challenges in forecasting and significant threats to human life and property. In searching for the key features that distinguish explosive cyclones (ECs) from ordinary extratropical cyclones (OCs), this study presents detailed comparison of winter ECs versus OCs in the perspective of potential vorticity (PV) using 10 years of reanalysis data with high temporal and spatial resolutions. ECs feature greater low-level baroclinity and stronger PV than OCs. The decomposition of local PV tendency shows the important contribution of cold advection (with correlation coefficient of 0.8) in the initial development of ECs. A stronger cold advection for ECs increases upstream static stability, leading to intrusion of higher PV along the steeper isentropic surfaces. The importance of cold advection is further proved by numerical experiments with the Weather Research and Forecast (WRF) model on a typical winter EC. The weakening of cold advection within low-troposphere in sensitivity experiment can significantly decrease PV and stop the cyclone from explosive deepening. In addition to the consensus that diabatic processes play important roles in the intensification of explosive cyclogenesis, this study emphasizes the importance of horizontal cold advection (which is also associated with baroclinic instability) in the preconditioning PV for explosive cyclogenesis.
Spatiotemporal Variability of Weather Extremes Over Eastern India: Evidences of Ascertained Long Term Trend Persistence and Effective Global Climate Controls
Authors: Saha Saurav , Chakraborty Debasish , Hazarika Samarendra , Shakuntala I. , Das Bappa , Chhabra Aakash , Sadhu S , Chakraborty Debashis , Mukherjee J , Singson Lungmuana , Mishra V.K. 
Published: December 2021

Abstract
The present study acknowledged climate variability induced periodic variation in localized extreme weather event occurrences under diverse agro eco-regions of Eastern Himalayas of India during past five decades. The widespread rise in warm nights (TN90p; 0.31-1.67 days year-1), reduced daily rainfall intensity (SDII) and changes in other weather extremes viz. temperature and precipitation extremes signified clear signals on regional atmospheric warming across eastern India. The agro-ecological regions under extended Bramhaputra valley and coastal belts of south Bengal experienced the most persistent shifts in temperature extremes, while the upper Himalayan range extended from North Bengal to Arunachal Pradesh experienced the steepest decline in average daily rainfall intensity and other absolute quantitative estimates of precipitation extremes over past five decades. Together with El Niño and La Niña events, large scale global atmospheric circulations particularly expansion of warmer Pacific Warm Pool (PWP) and changes in Atlantic Meridional Mode (AMM) contributed the periodic dynamics in weather extreme occurrences from monthly to annual time scale over eastern India. Our findings will be useful for better understanding of regional climatology, designing and successful implantation of location-specific suitable agricultural policies towards climate change adaptation in near future.
A Mixed-Methods Study of the Technical Feasibility and Patient Acceptability of a Real-Time Adherence Monitor in Breast Cancer Survivors Taking Adjuvant Endocrine Therapy
Authors: Bright Emma E. , Genung Sarah R. , Stanton Annette L , Arch Joanna J. 
Published: December 2021

Abstract
Purpose: Oral anti-cancer medications are increasingly common and endocrine therapies represent the most common oral anti-cancer medications in breast cancer. Adjuvant endocrine therapies reduce the likelihood of recurrence and mortality in the approximately 80% of women diagnosed with hormone-receptor positive breast cancer, thus rendering adherence essential. Real-time medication adherence monitors, such as the Wisepill electronic pillbox, transmit adherence data remotely, allowing for early intervention for non-adherence. However, their feasibility and acceptability have yet to be examined among breast cancer survivors taking endocrine therapies.Methods: This study presents quantitative patient-report and technical support data and qualitative patient acceptability data on using Wisepill, a common real-time adherence monitor, among 88 breast cancer survivors prescribed adjuvant endocrine therapy.Results: This mixed-methods study of a common real-time adherence monitor, among the first in breast cancer survivors taking adjuvant endocrine therapy, demonstrates its technical feasibility and patient acceptability.Conclusion: The use of wireless medication monitors that transmit real-time adherence data are uniquely promising for maximizing the benefits of adjuvant endocrine therapy by allowing for continuous tracking, ongoing communication with oncologic or research teams, and early intervention. This study demonstrates the feasibility and patient acceptability of one such real-time adherence monitor.
Clinical and immunological efficiency of different therapy regimens in patients with infectious mononucleosis caused by Epstein-Barr virus
Authors: Ksenia Pavlikova , Liadova Tetiana , Volobueva Olga , Gololobova Olesya , Vinnikova Nataliia 
Published: December 2021

The aim of the study was to evaluate the effectiveness of ribonucleic acid in the correction of immune disorders in patients with infectious mononucleosis (IM) caused by EBV.
Materials and methods. We examined 110 patients with a mean age of 23.3±4.2 years with IM, among whom women accounted for 52.7 % (n=58). The material for the study was the serum of patients obtained during the disease course. The set of tests of patients with IM included clinical and biochemical methods, enzyme-linked immunosorbent assay, polymerase chain reaction method, immunogram. Statistical processing of the obtained data was performed with “Statsoft Statistica v. 10.0 for Windows” using the methods of variation and correlation statistics.
Results. The obtained results analysis revealed changes in the system of cellular and humoral parts of the immune system and the diversity of the immune response in patients with IM. The progressive nature of changes in immune parameters indicated the formation of secondary cellular immune imbalance, activation of the humoral link, a change in the balance of immunoregulatory mediators towards Th2 cells. Significant changes in the cellular immune system were observed in the acute period and were characterized by the increase in the number of cells with killer activity, namely mature T-lymphocytes (CD3+), cytotoxic T-suppressor cells (CD8+), cells expressing the activation marker CD25+ (IL-2 receptor), and by the Th1/Th2 ratio increase. The appointment of combination therapy including ribonucleic acid was accompanied by immunomodulatory and antiviral effects, that was reflected in a more pronounced positive dynamics of immunological parameters, namely in strengthening the proliferative response, compared with the group of patients receiving only basic therapy.
Conclusion. The expediency of the combination therapy application: the drug Nuclex (ribonucleic acid) (250 mg) 2 capsules 3 times a day for 14 days and valacyclovir (500 mg) at a dose of 1000 mg (2 tablets) 3 times a day for 14 days, is justified for the correction of immune disorders in patients with IM caused by EBV.
A ABSTRATIVIZAÇÃO DO CONTROLE DIFUSO DE CONSTITUCIONALIDADE NO ÂMBITO DO STF E A (IN)CONSTITUCIONALIDADE DOS ARTS. 525, §12º, 535, §5º, DO NOVO CÓDIGO DE PROCESSO CIVIL DE 2015
Authors: ARAUJO JÚNIOR AMARO BANDEIRA DE 
Published: December 2021

RESUMO
Os novos influxos relativos à abstrativização do controle difuso de constitucionalidade na jurisprudência do Supremo Tribunal Federal aliado aos dispositivos inseridos no novo Código de Processo Civil, em especial a norma insculpida no art. 525, §12º, revelam uma força normativa desproporcional legalmente fixada aos precedentes judiciais oriundos da Corte Constitucional brasileira que podem levar à violação das garantias constitucionais processuais. O presente trabalho intenta analisar a inconstitucionalidade do nóvel dispositivo processual, ao mesmo tempo em que busca realizar uma análise sobre o espectro possível de limitações hermenêuticas, para além daqueles tradicionalmente aplicados, que podem ser utilizadas para um controle racional mínimo dos fundamentos dos precedentes judiciais vinculantes oriundos das decisões tomadas em controle difuso de constitucionalidade pelo STF.
Palavras-Chave: Abstrativização. Controle difuso. Constitucionalidade. Garantias processuais. Execução. Hermenêutica. Coisa julgada.

ABSTRACT
The new influxes related to the abstractivization of the diffuse control of constitutionality in the jurisprudence of the Federal Supreme Court, combined with the provisions inserted in the new Code of Civil Procedure, especially the norm inscribed in art. 525, paragraph 12, reveal a disproportionate normative force legally fixed to judicial precedents from the Brazilian Constitutional Court that may lead to violation of constitutional procedural guarantees. The present work tries to analyze the unconstitutionality of the new procedural device, at the same time as it seeks to perform an analysis on the possible spectrum of hermeneutical limitations, beyond those traditionally applied, that can be used for a minimal rational control of the grounds of the binding legal precedents stemming from the decisions made in diffuse control of constitutionality by the STF.
Keywords: Abstractivization. Diffuse control. Constitutionality. Procedural safeguards. Execution. Hermeneutics. Thing judged.
Prevalence of White Spot Caries Lesions in Primary Teeth in Preschool Children: Systematic Review and Meta-analysis
Authors: Campos Priscila H. , Gimenez Thais , Rocha Rafael S. , Caneppele Taciana M.F. , Guaré Renata O. , Lussi Adrian , Bresciani Eduardo , Diniz Michele B. 
Published: December 2021

Background:
The first clinically detectable stage of caries lesion is a non-cavitated
white spot lesion (WSL). The detection of early stages of caries lesions allows non-invasive management
by fluoride usage, oral hygiene and diet control. There is a lack of information in the literature
regarding the prevalence of these caries lesions in preschool children, which is important especially
for public health strategies.

Objective:
The aim of this study was to conduct a systematic review with meta-analysis to verify
the WSLs prevalence in primary teeth of preschool children.

Methods:
A literature search with MEDLINE/PubMed, Scopus, Web of Science, and Open Gray
databases was conducted. Included studies fulfilled the eligibility criteria. Meta-analyses were performed
using random effects model, for prevalence of pooled WSLs and subgroups analyses.

Results:
The search strategy identified 4922 potentially relevant articles, with final inclusion of 16
studies. The pooled prevalence of WSLs in primary teeth was 14.0% (95% CI: 8.0-24.0), without
publication bias (p=0.2668). For subgroup analyses, an increase in WSLs prevalence for children
of low-income economy (24.0%; 95% CI: 20.0-28.0), for age >31 months (22.0%; 95% CI:
12.0-37.0), for validated visual criteria assessment (20.0%; 95% CI: 11.0-33.0), and for tactile assessment
with ball-ended probe (26.0%; 95% CI: 11-50.0) were detected.

Conclusion:
It is suggested that the prevalence of WSLs in primary teeth of preschool children increases
in countries with low income economy, with age greater than 31 months or texture assessment
with visual validated criteria or ball-ended probe.

PROSPERO Registration:
Protocol number #CDR42017078434.
Distinguishing Intramedullary Spinal Cord Neoplasms from Non-Neoplastic
Conditions by Analyzing the Classic Signs on MRI in the Era of AI
Authors: Lim Ernest Junrui , Leong Natalie Wei Lyn , Ho Chi Long 
Published: December 2021

:
Intramedullary lesions can be challenging to diagnose, given the wide range of possible
pathologies. Each lesion has unique clinical and imaging features, which are best evaluated using
magnetic resonance imaging. Radiological imaging is unique with rich, descriptive patterns and
classic signs-which are often metaphorical. In this review, we present a collection of classic MRI
signs, ranging from neoplastic to non-neoplastic lesions, within the spinal cord. The differential diagnosis
(DD) of intramedullary lesions can be narrowed down by careful analysis of the classic
signs and patterns of involvement in the spinal cord. Furthermore, the signs are illustrated memorably
with emphasis on the pathophysiology, mimics, and pitfalls. Artificial intelligence (AI) algorithms,
particularly deep learning, have made remarkable progress in image recognition tasks. The
classic signs and related illustrations can enhance a pattern recognition approach in diagnostic radiology.
Deep learning can potentially be designed to distinguish neoplastic from non-neoplastic processes
by pattern recognition of the classic MRI signs.
Non-histone Methylation of SET7/9 and its Biological Functions
Authors: Song Peng , Li Qing , Gao Lili , Yu Weiping 
Published: December 2021

Background:
(su(var)-3-9,enhancer-of-zeste,trithorax) domain-containing protein 7/9
(SET7/9) is a member of the protein lysine methyltransferases (PLMTs or PKMTs) family. It contains
a SET domain. Recent studies demonstrate that SET7/9 methylates both lysine 4 of histone 3
(H3-K4) and lysine(s) of non-histone proteins, including transcription factors, tumor suppressors,
and membrane-associated receptors.

Objective:
This article mainly reviews the non-histone methylation effects of SET7/9 and its functions
in tumorigenesis and development.

Methods:
PubMed was screened for this information.

Results:
SET7/9 plays a key regulatory role in various biological processes such as cell proliferation,
transcription regulation, cell cycle, protein stability, cardiac morphogenesis, and development.
In addition, SET7/9 is involved in the pathogenesis of hair loss, breast cancer progression, human
carotid plaque atherosclerosis, chronic kidney disease, diabetes, obesity, ovarian cancer, prostate
cancer, hepatocellular carcinoma, and pulmonary fibrosis.

Conclusion:
SET7/9 is an important methyltransferase, which can catalyze the methylation of a variety
of proteins. Its substrates are closely related to the occurrence and development of tumors.
Effects of Nigella Sativa (Black seeds) Supplementation on Plasma Lipid
Profile in Human Subjects - A Review
Authors: Maideen Naina Mohamed Pakkir 
Published: December 2021

:
Dyslipidemia is the major risk factor for atherosclerotic cardiovascular disease
(ASCVD), cerebrovascular disease, and peripheral artery disease (PAD). It is characterized by higher
plasma concentrations of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c),
apolipoprotein B (apoB), very low-density lipoprotein-cholesterol (VLDL-c), triglycerides (TGs)
and low levels of high-density lipoprotein-cholesterol (HDL-c). Herbal medicines are preferred by
many across the globe particularly to manage chronic conditions such as dyslipidemia, hypertension,
type 2 diabetes, cancer, and plenty of others. Nigella sativa (black seeds or black cumin seeds)
is a miracle herb employed within the management of many sicknesses for centuries. Hence, this
review focuses on the ameliorative effects of N. sativa on the plasma lipid concentrations of human
subjects. Numerous randomized controlled clinical trials (RCTs) and different clinical studies demonstrated
that N. sativa possesses potential anti-dyslipidemic activity. The patients with dyslipidemia
may well be benefited by using N. sativa along with healthy lifestyle changes and statin and
other antihyperlipidemic medications as adjuvant therapy if needed.
Voice and Silence in Jacqueline Woodson’s Brown Girl Dreaming
Authors: Van Lierop-Debrauwer Helma 
Published: December 2021

In 2014, the American writer Jacqueline Woodson published Brown Girl Dreaming, the story of her childhood in free verse, which was classified as young adult literature. Most US reviewers characterized and appreciated the book both as a human rights narrative of a young brown girl’s coming of age against the socio-political background of racism and the Civil Rights Movement in the United States of the 1960s, and as a personal history of her development as a writer.
In this article the major focus will be on how Brown Girl Dreaming as both a political memoir and an autobiographical narrative of identity formation is fleshed out. On the basis of my analysis of these two plot lines, I will further argue that its categorization as young adult literature disguises that the novel addresses a dual audience of adult and young readers. In my argumentation related to the political and personal character of the novel, as well as in my discussion of the crossover potential of Brown Girl Dreaming, I will focus on the presence of voice and silence.
O CONHECIMENTO EM ANÁLISE NA FORMAÇÃO DE PROFESSORES DE CIÊNCIAS BIOLÓGICAS
Authors: Branco Alessandra Batista de Godoi , Silva Susane Closs da , Branco Emerson Pereira , Nagashima Lucila Akiko 
Published: December 2021

O artigo é resultado de pesquisa qualitativa com revisão de literatura e documental. Nesse estudo, objetivou-se analisar a percepção de um grupo de licenciandos em Ciências Biológicas sobre o conhecimento no processo de ensino e de aprendizagem no contexto escolar. A partir disso, buscou-se relacionar a modelos pedagógicos e epistemológicos, de acordo com referencial teórico. Para tanto, os objetos de análise foram atividades realizadas pelos participantes: (1) a resposta à pergunta sobre concepção de conhecimento e (2) desenhos sobre como se dá o conhecimento no processo de ensino e de aprendizagem na escola. Nos encontros foram produzidos escritos e desenhos, os quais foram lidos, observados, estudados e categorizados pelo método de análise de conteúdo. Como resultado, os participantes da pesquisa apresentaram concepções variadas de conhecimento sobressaindo características da tendência empirista, valorizando a exposição, a ideia de transmissão, a reprodução, entre outros. Os desenhos representaram concepções ligadas principalmente ao empirismo e ao construtivismo. Em relação aos indivíduos retratados, foi mais recorrente a figura da professora à frente da turma, distante dos alunos e expondo o conteúdo. Os estudantes foram desenhados por todos os acadêmicos, a maioria sem distinção de gênero, sentados e passivos ou em pé, aparentemente alheios à aula. Foram representadas interações interpessoais e muitos dos estudantes voltados fisicamente em direção ao professor. Sobre o espaço, sobressaiu a sala de aula, com quadro, carteiras enfileiradas e giz. Assim, o modelo pedagógico sugere que características do empirismo foram mais recorrentes nas atividades elaboradas pelo grupo participante.
A Pesquisa em Artes Cênicas pelo Grupo Tercer Abstracto
Authors: Trotta Rosyane 
Published: December 2021

O grupo chileno-brasileiro Tercer Abstracto, que atua desde 2012 e tem nove obras no percurso, vem buscando aproximar o teatro da ciência, como investigação performativa. Segundo sua página virtual (https://tercerabstracto.com/), “a investigação guia a criação” e, nesse contexto, o processo “parte de uma pergunta, um problema”. O grupo investe em duas linhas de projeto: a Série Abstracto se dedica ao estudo de artistas visuais, principalmente da abstração; o Projeto Manifestos se debruça sobre os encenadores da modernidade – nessa linha, a primeira peça foi Convenção, a partir de Meyerhold, e a segunda foi Épico, a partir de Brecht. No dia 11 de maio de 2021, os integrantes Mateus Fávero, ator e dramaturgista, e David Atencio, diretor, apresentaram sua metodologia de criação para os alunos da disciplina Laboratório de Encenação, ministrada na UNIRIO por Rosyane Trotta. Aqui, trazemos uma síntese dessa entrevista. Palavras-chavesPesquisa em Artes. Metodologia Artística. Teatro de Grupo.
Clinical Spectrum and Neuroimaging Changes in Neurodegenerative Disorder-Experiences in Tertiary Care Hospital of Bangladesh
Authors: Kundu Gopen Kumar , Islam Rumana , E-Sabah Noor , Mukib ABM 
Published: December 2021

Neurodegenerative diseases (NDD) are a heterogeneous group of disorders characterized by progressive loss of previously acquired skills that are of varied etiology, clinical manifestations, and natural course. There is a paucity of data on clinical profile of neurodegenerative diseases in our population.
We conducted a retrospective study with 68 diagnosed cases of NDD at a tertiary care hospital in Bangladesh. Among them, more than one-third of children were in 1-5 years age group. The mean age was 10.2±3.1 year and male to female ratio was 2:1. Fifty percent of cases had a history of consanguineous parents. Leukodystrophy was most common (30.88%) among NDDs, followed by Wilson disease (26.47), SSPE (22.1%), and Degenerative Ataxia (20.59%).
Motor skill regression was the most common presentation (97%), followed by speech regression in 91% and Gait disorder in 83% of children. Seizure was presenting features in 24% of children. Neuroimaging abnormalities were found in 80.88% NDD cases. Among them white matter hyper intensity in 29.41%, cerabeller atrophy in 13.25 %, and cerebral atropy in 11.76% of children. Eye changes were found in about two-thirds (69.12%) of cases of NDD. Among them, optic atrophy was found in 29.41%, and KF rings in 25.00% of cases.
Pengembangan Instrumen Penilaian Sikap Mahasiswa PG-PAUD FIP Unimed dalam Pembelajaran Daring
Authors: Sinaga Roni 
Published: December 2021

Penilaian sikap dalam pembelajaran daring akibat dampak dari munculnya virus corona menghadirkan tantangan kepada dosen di lingkungan PG-PAUD Fakultas Ilmu Pendidikan UNIMED, dimana instrumen tersebut belum ada, maka pengembangan diperlukan untuk menciptakan instrumen penilaian sikap mahasiswa dalam menjalankan pembelajaran daring. Penelitian ini bertujuan mengembangkan instrumen penilaian sikap mahasiswa PG-PAUD Fakultas Ilmu Pendidikan UNIMED dalam pembelajaran daring, pengembangan instrumen dilakukan dengan metode penelitian yang dikembangkan Borg & Gall dengan tahapan (1) Research and information collecting, (2) Planning, (3) Develop preliminary form of product, (4) Preliminary field testing, (5) Main product revision, (6) Main field testing, (7) Operational product revision, (8) Operational field testing, (9) Final product revision, (10) Dissemination and implementation. pengembangan instrumen dilakukan berdasakan SNPT yang tertuang dalam Permenristekdikti no 44 tahun 2015, serta mempedomani panduan penyusunan kurikulum Pendidikan tinggi di era industri 4.0. subjek yang terlibat dalam penelitian ini terdiri dari ahli materi dan dosen PG-PAUD. Pengumpulan data dilakukan dengan menggunakan wawancara, instrumen skala penilaian dan daftar ceklis. Teknik analisis data dilakukan dengan analisis deskriptif kuantitatif. Produk akhir yang diperoleh setelah melalui keseluruhan tahap dalam metode penelitian sudah layak digunakan dengan kriteria baik, dimana Hasil uji coba pada kelompok kecil diperoleh nilai rata-rata 4,20 (baik) dan kelompok besar dengan nilai rata-rata 4,4 (baik). produk akhir berupa instrumen penilaian sikap di unggah kedalam google form yang dapat dengan mudah diakses dan diimplementasikan pada pembelajaran daring.