bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rates of early complications and mortality in patients older than 80 years of age after surgical treatment of acute traumatic spinal fractures: ankylosing spondylitis versus osteoporosis
Authors: Ishak Basem , Frieler Sven , Rustagi Tarush , von Glinski Alexander , Blecher Ronen , Norvell Daniel C. , Unterberg Andreas , Strot Sarah , Roh Jeffrey , Hart Robert A. , Oskouian Rod , Chapman Jens R. 
Published: October 2021

OBJECTIVE
The purpose of this retrospective cohort study was to analyze the early complications and mortality associated with multilevel spine surgery for unstable fractures in patients older than 80 years of age with ankylosing spondylitis and to compare the results with an age- and sex-matched cohort of patients with unstable osteoporotic fractures.

METHODS
A retrospective review of the electronic medical records at a single institution was conducted between January 2014 and December 2019. Patient demographics, surgical characteristics, complications, hospital course, and 90-day mortality were collected. Comorbidities were stratified using the age-adjusted Charlson Comorbidity Index (CCI).

RESULTS
Among 11,361 surgically treated patients, 22 patients with ankylosing spondylitis (AS group) and 24 patients with osteoporosis (OS group) were identified. The mean ages were 83.1 ± 3.1 years and 83.2 ± 2.6 years, respectively. A significant difference in the mean CCI score was found (7.6 vs 5.6; p < 0.001). Multilevel posterior fusion procedures were conducted in all patients, with 6.7 ± 1.4 fused levels in the AS group and 7.1 ± 1.1 levels fused in the OS group (p > 0.05). Major complications developed in 10 patients (45%) in the AS group compared with 4 patients (17%) in the OS group (p < 0.05). The 90-day mortality was 36% in the AS group compared with 0% in the OS group (p < 0.001).

CONCLUSIONS
Patients older than 80 years of age with AS bear a high risk of adverse events after multilevel spinal fusion procedures. The high morbidity and 90-day mortality should be clearly discussed and carefully weighed against surgical treatment.
Management of spine fractures in ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis: a challenge
Authors: Schwendner Maximilian , Seule Martin , Meyer Bernhard , Krieg Sandro M. 
Published: October 2021

OBJECTIVE
Ankylosing spinal disorders (ASDs) such as ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH) are complex diseases regarding diagnostics, treatment, and patient outcome, especially in trauma. Originating from rigid biomechanics and low bone quality in considerably comorbid patients, serious spinal injury requires thorough and immediate imaging and is frequently missed. The aim of this study was to evaluate patient characteristics as well as procedures in patients with ASD in order to identify the major particularities of treatment.

METHODS
A total of 60 patients aged 78.5 ± 8.9 years were retrospectively included. Preoperative imaging as well as surgical treatment procedures and postoperative patient outcome were analyzed, including 30-day readmissions.

RESULTS
CT imaging of the entire spine was performed within 24 hours after the initial trauma in 73.3% of patients. A delay in diagnostics (> 24 hours) occurred in 41.7% of patients transferred from primary care centers. At admission, 25.0% of patients had fracture-related neurological deficits (American Spinal Injury Association [ASIA] grades A and B in 4 patients, and ASIA grades C and D in 11 patients). A spinal epidural hematoma was found in 21.2% of patients and was symptomatic in 72.7% of those patients. Of the patients with fracture-related neurological deficits, 93.3% were operated on within 48 hours from symptom onset. One patient (1.7%) developed neurological deficits from diagnosis to surgery. Postoperatively, 18.3% of patients had surgical complications, and 76.7% of patients developed further medical issues, with pneumonia (38.3%), pulmonary decompensation (25.0%), and cardiac decompensation (20.0%) being the leading causes. The 30-day mortality rate was high at 10.0%.

CONCLUSIONS
Treatment of patients with ASDs is complex. While surgical outcome is usually good, the multimorbid nature of these patients results in a high rate of major medical complications. If an ankylosing disease is suspected, MRI of the entire spine is mandatory. Upon diagnosis, treatment should be performed in centers capable of managing all aspects of the regular complications these patients will develop.
Epidural hematoma in patients with ankylosing spondylitis requiring surgical stabilization: a single-institution retrospective review with literature analysis
Authors: Hanna George , Uddin Syed-Abdullah , Trontis Andrew , Ross Lindsey , Drazin Doniel , Kim Terrence T. , Johnson J. Patrick 
Published: October 2021

OBJECTIVE
Ankylosing spondylitis (AS) is a chronic inflammatory disease affecting the sacroiliac joints and axial spine that is closely linked with human leukocyte antigen–B27. There appears to be an increased frequency of associated epidural hematomas in spine fractures in patients with AS. The objective was to review the incidence within the literature and a single-institution experience of the occurrence of epidural hematoma in the context of patients with AS requiring spine surgery.

METHODS
Deep 6 AI software was used to search the entire database of patients at a single level I trauma center (since the advent of the institution’s modern electronic health record system) to look at all patients with AS who underwent spinal surgery and who had a diagnosis of epidural hematoma. Additionally, a systemic literature review was performed of all papers evaluating the incidence of epidural hematoma in patients with spine fractures.

RESULTS
A single-institution, retrospective review of records from 2009 to 2020 yielded a total of 164 patients with AS who underwent spine surgery. Of those patients, 17 (10.4%) had epidural hematomas on imaging, with the majority requiring surgical decompression. These spine fractures occurred close to the cervicothoracic or thoracolumbar junction. The patients ranged in age from 51 to 88 years, and there were 14 males and 3 females in the cohort. Eight patients were administered an antiplatelet and/or anticoagulant agent, and the rest were not. All patients required surgical stabilization, with 64.7% of patients also requiring decompressive laminectomies for evacuation of the hematoma and spinal cord decompression. Only 1 death was reported in the series. There was a tendency toward neurological improvement after surgical intervention.

CONCLUSIONS
AS has been a well-described pathologic process that leads to an increased risk of three-column injury in spine fracture, with an increased incidence of symptomatic epidural hematoma compared with patients without AS. Early recognition of this entity is important to ensure that appropriate surgical management includes addressing compression of the neural elements in addition to surgical stabilization.
Endoscopic resection through a retrosigmoid transmeatal approach of a large-sized vestibular schwannoma: operative video and technical nuances
Authors: Giovannini Sebastián J. M. , Caffaratti Guido , Centeno Tomas Ries , Ruella Mauro , Villamil Facundo , Marengo Ricardo , Cervio Andrés 
Published: October 2021

Surgical management of vestibular schwannomas has improved over the last 30 years. Whereas in the past the primary goal was to preserve the patient’s life, today neurological function safeguarding is the main objective, with numerous strategies involving single resection, staged resections, postoperative radiosurgery, or single radiosurgery.
The retrosigmoid approach remains the primary pathway for surgical access to the cerebellopontine angle (CPA). The use of an endoscope has great advantages. It contributes to the visualization and resection of residual tumor and also reduces the need for cerebellar retraction.
The authors present a fully endoscopic resection of a large-sized vestibular schwannoma with facial nerve preservation.
The video can be found here: https://stream.cadmore.media/r10.3171/2021.7.FOCVID21106
Translabyrinthine resection of NF2 associated vestibular schwannoma with cochlear implant insertion
Authors: Hannan Cathal John , Sharma Priya , Smith Matthew Edward , Glancz Laurence Johann , O’Driscoll Martin , King Andrew Thomas , Hammerbeck-Ward Charlotte , Evans Dafydd Gareth , Rutherford Scott Alexander , Lloyd Simon Kinsella , Freeman Simon Richard Mackenzie , Pathmanaban Omar Nathan 
Published: October 2021

The authors present the case of a 24-year-old female with neurofibromatosis type 2. Growth of the left vestibular schwannoma and progressive hearing loss prompted the decision to proceed to translabyrinthine resection with cochlear nerve preservation and cochlear implant insertion. Complete resection with preservation of the facial and cochlear nerves was achieved. The patient had grade 1 facial function and was discharged on postoperative day 4 following suturing of a minor CSF leak. This case highlights the feasibility of cochlear nerve preservation and cochlear implant insertion in appropriately selected patients, offering a combination of effective tumor control and hearing rehabilitation.
The video can be found here: https://stream.cadmore.media/r10.3171/2021.7.FOCVID21122
Rate of craniometric change following suture release in patients with metopic and sagittal craniosynostosis
Authors: Leclair Nathan K. , Lambert William A. , Knopf Joshua , Stoltz Petronella , Hersh David S. , Martin Jonathan E. , Bookland Markus J. 
Published: October 2021

OBJECTIVE
Craniosynostosis is a congenital disorder resulting from the premature fusion of cranial sutures in the infant skull. This condition results in significant cosmetic deformity and can impede neurodevelopment, if left untreated. Currently, rates of craniometric change following minimally invasive surgery have only been examined for sagittal craniosynostosis. A better understanding of postoperative skull adaptations in other craniosynostosis subtypes is needed to objectively categorize surgical outcomes and guide length of cranial orthosis therapy.

METHODS
Eleven patients with sagittal and 8 with metopic craniosynostosis treated using endoscopic strip craniectomy and postoperative helmet orthoses were retrospectively reviewed. Using semiautomated image analysis of top-down orthogonal 2D photographs, the following craniometrics were recorded before surgery and at postoperative visits: cephalic index (CI), cranial vault asymmetry index (CVAI), anterior arc angle (AAA), posterior arc angle (PAA), anterior-middle width ratio (AMWR), anterior-posterior width ratio (APWR), left-right height ratio (LRHR), sagittal Hu moment (Sag-Hu), and brachycephaly Hu moment (Brachy-Hu). These craniometrics were then normalized to photograph-based measurements of normocephalic patients and the rates of change between metopic and sagittal craniosynostoses were compared.

RESULTS
Patients with sagittal craniosynostosis exhibited significantly lower CI, lower PAA, higher AMWR, higher APWR, lower Sag-Hu, and higher Brachy-Hu preoperatively compared to patients with normocephalic craniosynostosis. Patients with metopic craniosynostosis exhibited lower AAA and AMWR preoperatively compared to normocephalic subjects. Sagittal and metopic patients had a rapid initial change in normalized CI or AAA, respectively. Craniometric rates of change that significantly differed between metopic and sagittal patients were found in AAA (p < 0.001), AMWR (p < 0.001), and APWR (p < 0.0001). Metopic patients had a prolonged AAA change with a significantly different rate of change up to 6 months postoperatively (median at 3 months = 0.027 normalized units/day, median at 6 months = 0.017 normalized units/day, and median at > 6 months = 0.007 normalized units/day), while sagittal CI rate of change at these time points was not significantly different.

CONCLUSIONS
Patients with metopic craniosynostosis have a prolonged rate of change compared to patients with sagittal craniosynostosis and may benefit from longer helmet use and extended postoperative follow-up. Categorizing craniometric changes for other craniosynostosis subtypes will be important for evaluating current treatment guidelines.
Arterial spin labeling as an ancillary assessment to postoperative conventional angiogram in pediatric moyamoya disease
Authors: Lang Shih-Shan , Tucker Alexander M. , Schreiber Craig , Storm Phillip B. , Liu Hongyan , Li Yimei , Ichord Rebecca , Beslow Lauren A. , Sedora-Roman Neda I. , Cox Mougnyan , Nasser Hussein , Vossough Arastoo , Fisher Michael J. , Kilbaugh Todd J. , Huh Jimmy W. 
Published: October 2021

OBJECTIVE
Digital subtraction angiography (DSA) is commonly performed after pial synangiosis surgery for pediatric moyamoya disease to assess the degree of neovascularization. However, angiography is invasive, and the risk of ionizing radiation is a concern in children. In this study, the authors aimed to identify whether arterial spin labeling (ASL) can predict postoperative angiogram grading. In addition, they sought to determine whether patients who underwent ASL imaging without DSA had similar postoperative outcomes when compared with patients who received ASL imaging and postoperative DSA.

METHODS
The medical records of pediatric patients who underwent pial synangiosis for moyamoya disease at a quaternary children’s hospital were reviewed during a 10-year period. ASL-only and ASL+DSA cohorts were analyzed. The frequency of preoperative and postoperative symptoms was analyzed within each cohort. Three neuroradiologists assigned a visual ASL grade for each patient indicating the change from the preoperative to postoperative ASL perfusion sequences. A postoperative neovascularization grade was also assigned for patients who underwent DSA.

RESULTS
Overall, 21 hemispheres of 14 patients with ASL only and 14 hemispheres of 8 patients with ASL+DSA were analyzed. The groups had similar rates of MRI evidence of acute or chronic stroke preoperatively (61.9% in the ASL-only group and 64.3% in the ASL+DSA group). In the entire cohort, transient ischemic attack (TIA) (p = 0.027), TIA composite (TIA or unexplained neurological symptoms; p = 0.0006), chronic headaches (p = 0.035), aphasia (p = 0.019), and weakness (p = 0.001) all had decreased frequency after intervention. The authors found a positive association between revascularization observed on DSA and the visual ASL grading (p = 0.048). The visual ASL grades in patients with an angiogram indicating robust neovascularization demonstrated improved perfusion when compared with the ASL grades of patients with a poor neovascularization.

CONCLUSIONS
Noninvasive ASL perfusion imaging had an association with postoperative DSA neoangiogenesis following pial synangiosis surgery in children. There were no significant postoperative stroke differences between the ASL-only and ASL+DSA cohorts. Both cohorts demonstrated significant improvement in preoperative symptoms after surgery. Further study in larger cohorts is necessary to determine whether the results of this study are validated in order to circumvent the invasive catheter angiogram.
Postępowanie w sprawach o naruszenie posiadania, czyli o konieczności ograniczenia ilości postępowań odrębnych w Kodeksie postępowania cywilnego. Wybrane zagadnienia
Authors: Góra- Błaszczykowska Agnieszka 
Published: October 2021

Podjęcie tematu wynika ze zwiększania liczby postępowań odrębnych w Kodeksie postępowania cywilnego, co powoduje odwrócenie istniejącej uprzednio i naturalnej proporcji między postępowaniem zwykłym, służącym rozpoznawaniu większości spraw, a postępowaniami odrębnymi, mającymi służyć wyłącznie rozpoznawaniu pewnych rodzajów spraw.
Przepisy art. 478 i 479 K.p.c. budzą poważne wątpliwości w praktyce sądów, nie są adekwatne do potrzeb praktyki i nie są w pełni skorelowane z przepisami prawa materialnego. Dlatego postępowanie w sprawach o naruszenie posiadania nie wymaga, zdaniem autorki, odrębnej regulacji i powinno zostać usunięte z Kodeksu.
The Term ἀντίψυχος as an Expiatory Sacrifice of Martyrs in the Light of The Fourth Book of Maccabees and Other Ancient Extra-Biblical Literature
Authors: Chrostowski Marcin Tomasz 
Published: October 2021

The Fourth Book of Maccabees (4 Macc) in the description of Eleazar's prayer, before he suffered a martyr’s death (6:29) as well as the martyrdom of seven brothers and their mother who suffered for the nation (17:21), the term ἀντίψυχος (which means “given in exchange for life”) is used twice. This adjective appears only twice in the Septuagint (LXX), to be precise, in 4 Macc The context of both passages suggests a broader meaning of the term, translated with reference to a sacrifice of life having a propitiatory, expiatory, vicarious and voluntary character, and even atonement for the sins of the Jewish people. In this article, the subject of expiatory martyrdom in 4 Macc will be taken in the context of the biblical, apocryphal and other ancient texts, with reference to the flow of ideas and terminology of Greco-Roman religion, poetry and philosophy. In addition, possible translations of the term ἀντίψυχος will be analyzed, included in the broader context of Greek and other terminologies, so as to show possible connections between the idea of ​​expiatory martyrdom and the ideas described in the New Testament.
The role of aggregate granulation on testing fracture properties of concrete
Authors: Słowik Marta 
Published: October 2021

Concrete is a porous material containing aggregate of different sizes, hardened cement matrix with air pores, microcracks and water. Concrete internal structure is different from that of other engineering materials. Furthermore concrete is described as quazi-brittle material. Fracture processes in it form in a way that does not fit within classical theories. Therefore, to describe failure of concrete structures nonlinear fracture mechanics is often applied with success. Basic concrete parameters, like compressive and tensile strength, and modulus of elasticity, are not enough to analyze fracture processes in concrete structures. Additional fracture properties should be tested, among them fracture energy, complete diagram of stress-deformation under axial tension and the width of fracture process zone. Recognizing and testing fracture parameters is of paramount importance when analysing fracture process in concrete structures. The correct data of material’s properties and the adequate fracture model applied in numerical simulations influence final results. In the paper the findings reported in the professional literature are summarized and obtained results of the own numerical simulation are reported in order to give a deeper knowledge on the role of aggregate on fracture properties of concrete.
ACTIVITY OF ANGIOTENSIN-CONVERSING ENZYME-2 IN ACUTE PULMONARY INFLAMMATION
Authors: Ziablitsev D.S. , Dyadyk O.O. , Ziablitsev S.V. 
Published: October 2021

Relevance. Angiotensin converting enzyme-2 (ACE2), which is the gateway to coronavirus, is also an important component of the tissue renin-angiotensin system with a number of anti-inflammatory effects. It is known that ACE2 is expressed in the lungs of patients with coronavirus pneumonia, but it is not clear how this depends on the stages of development and the severity of inflammation.
Objective: to establish the effect of acute inflammation on pulmonary expression of angiotensin-converting enzyme-2.
Material and methods. In Wistar rats (n=20), in compliance with bioethical standards, a sterile nylon thread 2.5 cm long and 0.2 mm thick to a depth of 2.5 cm was introduced into the trachea. The animals were observed and removed from the experiment at 7, 14, 21 and 28 days, microscopic and immunohistochemical (monoclonal antibodies against ACE2; clone 4G5.1; EMD Millipore Corporation; Temecula, CA US) studies were performed.
Results. The microscopic picture of the lungs indicated the development of acute bronchopulmonary inflammation during the first week, the formation of peribronchial and alveolar abscesses in the second week with the onset of resolution of bronchopneumonia with the organization of abscesses in the third week and the development of diffuse fibrosis of the parenchyma and vascular hyalinosis in the fourth week of observation. The exudative phase of acute inflammation was accompanied by inhibition of ACE2 activity in bronchial epithelial cells, type II alveolocytes and vascular endothelium. With the transition of inflammation to the stage of proliferation and fibrosis, ACE2 activity was restored.
Conclusion. The detected phase change in ACE2 activity can cause a wavy recurrent course of coronavirus infection, since an increase in the amount of ACE2 protein during attenuation of acute inflammation contributes to an increase in target cell infection.
ECOLOGICAL AND HYGIENIC ASSESSMENT OF NEW PESTICIDES FOR GRAIN CEREALS CHEMICAL PROTECTION
Authors: Korshun M.M. , Martіianova Y.V. 
Published: October 2021

Relevance. The use of pesticides in the national economy is to destroy or inhibit the growth of harmful plants and to protect crops from pathogens requires a mandatory assessment of their environmental hygienic hazard.
Objective of our study is to assess the hazards of three new pesticides for cereal grains protection: amicarbazone from the chemical class of triazolinone compounds, bicyclopyrone from the class of tricetones and pydiflumetofen from the class of carboxamides, in terms of ecotoxicity and environmental behavior.
Materials and methods. Hazard assessment of amicarbazone, bicyclopyrone and pydiflumetofen was performed on the basis of data sources on their physico-chemical characteristics, toxicometry parameters for different species of living things and indicators of environmental behavior. For potential hazards integral assess for terrestrial ecosystems an ecotox was calculated taking into account mammalian toxicity, persistence and maximum rate consumption. To identify the limiting section of migration, the mathematical modeling was performed in the systems "soil-water", "soil-plants" and "soil-atmospheric air".
Results. Amicarbazone has been shown to be extremely toxic to algae and highly toxic to higher aquatic plants (HAP) (hazard class I), moderately toxic (class IV) to mammals, mildly toxic (class III) to birds, soil mesofauna and invertebrates, virtually non-toxic to bees and fish; bicyclopyrone - extremely toxic to HAP (class I) and moderately toxic (class II) to the most sensitive algae, mildly toxic (class III) to birds, fish and invertebrates and virtually non-toxic to other terrestrial fauna; pydiflumetofen is highly toxic (class I) to fish and invertebrates, moderately toxic (class II) to algae and HAP, virtually non-toxic to all terrestrial biota. Pydiflumetofen has been shown to be a highly resistant and poorly mobile in soil; amicarbazone is stable and mobile; bicyclopyrone is highly resistant in laboratory experiments and moderately stable in field experiments, its mobility varies in a wide range: from very mobile to less mobile in some soils. The danger for terrestrial biocenoses of all studied pesticides under different soil and climatic conditions is lower by (1–5) orders of magnitude in comparison with DDT; the lowest is the ecotoxicity of bicyclopyrone, the highest – pydiflumetofen. All test substances are highly stable in water. The leading section of their migration in environment is the system "soil – water of ponds" and in case of pydiflumetofen – "soil – plants" as well.