bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systems biology in disease modeling and control, analysis and perspectives
Authors: Yue Rongting , Dutta Abhishek 
Published: June 2021

Abstract
Omics and drug molecules become increasingly influential in identifying disease mechanisms and drug response. Because diseases and drug responses are co-expressed and regulated in the relevant omics interactions, the traditional way that grabbing molecular data from single isolated layers cannot always obtain valuable inference. Also, adverse effects exist in drugs that impair patients, and launching new medicines for diseases is costly. To resolve the above difficulties, systems biology is then applied to predict potential molecular interaction elements by integrating omics data from genomic, proteomic, transcriptional, and metabolic layers. Combined with known drug reactions, the resulting models improve medicines’ therapeutical performance by re-purposing the existing drugs and combining drug molecules without off-target effects. Based on the identified computational models, drug administration control laws are designed to balance toxicity and efficacy. This review introduces biomedical applications and analyses of interactions among omics and drug molecules for modeling disease mechanism and drug response. The therapeutical performance can be improved by combining the predictive and computational models with drug administration designed by control laws. The challenges are discussed for its clinic uses.
Respons Of Islamic Stock Markets To Monetary Policy Empirical Evidence from Indonesia
Authors: Rasyidin Muhammad , Sulong Zunaidah 
Published: June 2021

AbstractPurpose - The impact of stock market and capital formation on economic growth in Indonesia for the period of January 2015 – May 2019. This paper examines a long-run equilibrium relation between stock market, capital formation and economic growth and other control variables.Method - This study uses autoregressive distributed lag (ARDL) model.Result - Findings revealed that none of the models was stationary at level but were all stationary at first difference. There is not a short run significant relationship between stock market, capital formation and economic growth in Indonesia. In the long run, capital formation has a significant positive association on economic growth and a negative non-significant relationship between stock market and economic growth in Indonesia.Implication - This research is useful to know the response of Sharia market to monetary policy instruments in Indonesia so that the Sharia stock market strategy is potentially developing in the future to encourage the achievement of characteristics such as An alternative source of financing and investment for economic actors and able to facilitate risk mitigation needs for market participants and able to drive the efficiency of transactions in the market through the improvement of the quality of stock market infrastructure Sharia. Originality - The update of this research is response of Sharia stock market response to monetary policy instruments in Indonesia that are researched using ARDL models.
Suggestions for improved dependability-related terminology
Authors: Zelentsov В. Р. 
Published: June 2021

Aim. This article aims to eliminate the shortcomings associated with the application of the conventional, yet insufficiently substantiated terms in the GOST 27.002-2015 interstate standard. Correct understanding and use of terms are of great significance for the activities of dependability experts.Methods. Shortcomings in terminology are eliminated by clarifying the definitions of the used terms. Several terms used in this standard were submitted to logical and terminological analysis that is based on statutory requirements and the semantic meanings of such terms. The premises were set forth in [8].Findings and conclusions. Definitions of several new terms, as well as those that do not meet the identified requirements are suggested: “dependability theory”, “dependability estimation”, “dependability calculation”, etc. The expressed considerations could provide the foundation for the adoption of agreed (com[1]promise) solutions.
Effectiveness retention ratio and its standardization
Authors: Netes V. A. 
Published: June 2021

Aim. To promote a better understanding, a wider and more correct application of the effectiveness retention ratio. That is the measure that is best suited for assessing the dependability of complex technical systems, in which partial failures are possible that put a system into intermediate states between complete up and down ones. Methods. The paper uses the methods of the probability theory and comparative analysis of texts of interstate (Euro-Asian), Russian and international dependability-related standards. Results. The principal contribution of Russian researchers to the creation and development of methods for applying effectiveness indicators to estimating the dependability of complex systems is pointed out. Shortcomings were identified in the basic dependability-related standards as regards the effectiveness retention ratio and related concepts. Namely, in terminology standard GOST 27.002–2015, the phrases that require improvement are indicated. They relate to the concepts of partial failure, partial up state and partial down state. A broader and more ac[1]curate definition of partial failure is suggested. It is noted that the relationship between partially up and partially down states are to be discussed and clarified. GOST 27.003–2016 that establishes the content and general rules for specifying dependability requirements contains wording errors in the classification of items according to the number of possible (taken into consideration) states and in the examples of possible variants of the effectiveness retention ratio in various branches of technology that are probabilities of task completion, etc. The paper suggests corrections to the appropriate wordings. It has been established that although the effectiveness retention ratio is not referred to in the international dependability-related terminology standard (IEC 60050-192:2015), it implicitly appears in two IEC standards (IEC 61703:2016 and IEC 62673:2013), in which it is assigned to availability measures. Conclusion. The paper’s findings will be useful to experts involved in the assessment and standardization of complex technical system dependability. Their implementation will help improve interstate, Russian and international dependability-related standards.
Identification of Generalized Peptide Regions for Designing Vaccine
Effective for All Significant Mutated Strains of SARS-CoV-2
Authors: Biswas Subhamoy , Manna Smarajit , Dey Tathagata , Chatterjee Shreyans , Dey Sumanta 
Published: June 2021

Background:
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection has
become a worldwide pandemic and created an utmost crisis across the globe. To mitigate the crisis, the
design of vaccine is the crucial solution. The frequent mutation of the virus demands generalized
vaccine candidates, which would be effective for all mutated strains at present and for the strains that
would evolve due to further new mutations in the virus.

Objective:
The objective of this study is to identify more frequently occurring mutated variants of
SARS-CoV-2 and to suggest peptide vaccine candidates effective against the viral strains considered.

Method:
In this study, we have identified all currently prevailing mutated strains of SARS-CoV-2
through 2D Polar plot and Quotient Radius (!!) characterization descriptor. Then, by considering the
top eight mutation strains, which are significant due to their frequency of occurrence, peptide regions
suitable for vaccine design have been identified with the help of a mathematical model, 2D Polygon
Representation, followed by the evaluation of epitope potential, ensuring that there is no case of any
autoimmune threat. Lastly, in order to verify whether this entire approach is applicable for vaccine
design against any other virus in general, we have made a comparative study between the peptide
vaccine candidates prescribed for the Zika virus using the current approach and a list of potential
vaccine candidates for the same already established in the past.

Results:
We have finally suggested three generalized peptide regions which would be suitable as
sustainable peptide vaccine candidates against SARS-CoV-2 irrespective of its currently prevailing
strains as well any other variant of the same that may appear in the future. We also observed that
during the comparative study using the case of E protein of Zika virus, the peptide regions suggested
using the new approach that matches with the already established results.

Conclusion:
The study, therefore, illustrates an approach that would help in developing peptide
vaccine against SARS-CoV-2 by suggesting those peptide regions which can be targeted irrespective
of any mutated form of this virus. The consistency with which this entire approach was also able to
figure out similar vaccine candidates for Zika virus with utmost accuracy proves that this protocol can
be extended for peptide vaccine design against any other viruses in the future.
Quality of Sleep Among Elderly with Hypertension at Werdha Institusion in West Java Province
Authors: Handayani Wening , Lukman Mamat , Mambang Sari Citra Windani 
Published: June 2021

Elderly are particularly vulnerable groups that is prone to experiencing a decline in health related to a physiological decline. Vulnerability such as changes in structure of blood vessel walls lead to increased incidence of hypertension. Moreover, in uncontrolled conditions, elderly with hypertension can suffer symptoms of sleeping disorder, changes of sleep pattern that triggers the increasing of blood pressure and affect sleep quality. The purpose of this descriptive quantitative research was to describe the sleep quality of elderly with hypertension based on seven components of sleep quality assessment.Â The research design used a descriptive quantitative with a cross-sectional approach. The study was conducted at Ciparay and Garut Elderly Social Rehabilitation Centre, with number of the sample obtained 37 elderlies who were elected by total sampling technique. The result of this study showed that 89,2% of respondents had poor sleep quality. Several conditions that stimulate poor sleep quality in the elderly come from high blood pressure which causes sleep disturbances, thereby changing several sleep components such as short sleep duration less than 6 hours, sleep latency 15-30 minutes, decreased sleep efficiency below 85%, and activity dysfunction in daytime.Â Future research is expected to be able to modify sleep quality measuring instruments that are specifically used to measure the quality of sleep for people with hypertension.
Effect of Woolen Cloth to Maintain Temperature 39Â°C of Crystaloid Fluid Ringer Lactate at Room Temperature 18Â°C
Authors: Fitriana Helna , Wahid Abdurrahman , Nasution Tina Handayani , Negara Gia Eka 
Published: June 2021

Fluid resuscitation with 39áµ’C is one of the main therapies for hypovolemic (hemorrhagic) shock patients to prevent complications. In this time, we already have tools to keep the fluid warm, but not all health services have these tools.Â To find out the effectiveness of using woolen cloth against the temperature of Ringer Lactate 39Â°C crystalloid fluid at room temperature 18Â°C. This study used a pre-experimental method, with a static group comparison approach, with 4 Ringer Lactate liquid samples divided into 2 groups, namely groups using wool cloth and those not using woolen cloth. Data collected through observation sheets. Data analyzed using the Mann Whitney test. With this p value (0.00001) <Î± (0.05), it can be concluded that there is a significant difference between the use of woolen cloth and those that do not use woolen cloth. The woolen cloth is effective to slow down the decrease in temperature of the crystalloid liquid Ringer Lactate 39áµ’C at room temperature 18áµ’C. The difference in temperature changes in the Ringer Lactate crystalloid fluid is influenced by several things including humidity, ambient temperature, and additional material used.
The Impact of Technology-Enabled Care Coordination in a Complex Mental Health System: A Local System Dynamics Model
Authors: Iorfino Frank , Occhipinti Jo-An , Skinner Adam , Davenport Tracey , Rowe Shelley , Prodan Ante , Sturgess Julie , Hickie Ian B 
Published: June 2021

Background
Prior to the COVID-19 pandemic, major shortcomings in the way mental health care systems were organized were impairing the delivery of effective care. The mental health impacts of the pandemic, the recession, and the resulting social dislocation will depend on the extent to which care systems will become overwhelmed and on the strategic investments made across the system to effectively respond.

Objective
This study aimed to explore the impact of strengthening the mental health system through technology-enabled care coordination on mental health and suicide outcomes.

Methods
A system dynamics model for the regional population catchment of North Coast New South Wales, Australia, was developed that incorporated defined pathways from social determinants of mental health to psychological distress, mental health care, and suicidal behavior. The model reproduced historic time series data across a range of outcomes and was used to evaluate the relative impact of a set of scenarios on attempted suicide (ie, self-harm hospitalizations), suicide deaths, mental health–related emergency department (ED) presentations, and psychological distress over the period from 2021 to 2030. These scenarios include (1) business as usual, (2) increase in service capacity growth rate by 20%, (3) standard telehealth, and (4) technology-enabled care coordination. Each scenario was tested using both pre– and post–COVID-19 social and economic conditions.

Results
Technology-enabled care coordination was forecast to deliver a reduction in self-harm hospitalizations and suicide deaths by 6.71% (95% interval 5.63%-7.87%), mental health–related ED presentations by 10.33% (95% interval 8.58%-12.19%), and the prevalence of high psychological distress by 1.76 percentage points (95% interval 1.35-2.32 percentage points). Scenario testing demonstrated that increasing service capacity growth rate by 20% or standard telehealth had substantially lower impacts. This pattern of results was replicated under post–COVID-19 conditions with technology-enabled care coordination being the only tested scenario, which was forecast to reduce the negative impact of the pandemic on mental health and suicide.

Conclusions
The use of technology-enabled care coordination is likely to improve mental health and suicide outcomes. The substantially lower effectiveness of targeting individual components of the mental health system (ie, increasing service capacity growth rate by 20% or standard telehealth) reiterates that strengthening the whole system has the greatest impact on patient outcomes. Investments into more of the same types of programs and services alone will not be enough to improve outcomes; instead, new models of care and the digital infrastructure to support them and their integration are needed.
Acerca del ángulo de influjo y su importancia en el desarrollo de los huracanes
Authors: Serra Castelán Sergio 
Published: June 2021

Los resultados de varios experimentos de un modelo numérico de un huracán, se presentan en este trabajo. El modelo se ha formulado en el sistema σ (p/po), es un modelo balanceado y tiene cuatro capas principales y una capa friccional y la red radial es de distribución no uniforme, tiene mayor resolución cerca del centro. El ángulo de influjo en la capa friccional se determina por la distribución dada por una espiral recíproca en la parte central y el criterio de la existencia de divergencia positiva en el resto de esta capa. La relación entre esta formulación y la "clásica", que usa el coeficiente de arrastre, se discute y se prueba que el uso de un coeficiente de arrastre dado es equivalente a usar un ángulo de influjo determinado. El ángulo de influjo tiene una distribución que da un valor máximo. Varios valores de este máximo se usaron en el modelo y se demuestra que un mínimo de 4°, para el ángulo máximo, es necesario para producir desarrollo en el modelo. En un experimento mediante variación del ángulo máximo de influjo un estado estable fue obtenido. Los distintos campos que se obtuvieron después de 90 horas de integración se presentan y todos ellos indican una distribución que se apega mucho a la realidad.
O reendereçamento de obras literárias por meio do projeto gráfico: 'Fita Verde no Cabelo', de Guimarães Rosa | The readressing of literary works via graphic projects: Fita 'Verde no Cabelo', by Guimarães Rosa
Authors: Luersen Paula , Inoue Gabriela Narumi 
Published: June 2021

ResumoEste artigo analisa o reendereçamento da obra Fita verde no cabelo: nova velha estória ao público infantojuvenil. Em 1992, o conto de Guimarães Rosa foi reeditado pela Nova Fronteira, contando com novo projeto gráfico e com as ilustrações de Roger Mello, em edição dedicada ao público jovem. Além de observar o modo como a obra busca o diálogo com esse público em níveis textuais e imagéticos, o estudo concentra-se na análise das ilustrações. Verifica-se a hipótese de que as imagens, em vez de apenas facilitarem a leitura para um público específico, expandem o sentido da obra original contemplando todos os públicos. Como resultado, demonstra-se a potência das imagens e sua capacidade de enriquecer a experiência de leitura do conto de Rosa.Palavras-chave: João Guimarães Rosa. Reendereçamento. Ilustração. AbstractThis article analyzes the readdressing of the work Fita verde no cabelo: nova velha estória to youth literature. In 1992, Guimarães Rosa's short story was reissued by Nova Fronteira. The book had a new graphic project by Roger Mello. This study focuses not only on how the story is looking for dialogue with the young audience in written-text and visual-image levels, but also in the analysis of illustrations. We verify the hypothesis that the images do not facilitate the reading process for a specific audience, for they are in turn ways to expand the meanings of the original work. The potential of those images is demonstrated along with their capacity to enrich the reading experience of Rosa's short story.Keywords: João Guimarães Rosa. Readdressing. Illustration.
Love and Belonging Needs in John Green’s The Fault in Our Stars
Authors: Dwi Permana Alvin , Tri Wedawati Mamik , Dhika Arif Rizqan Muhammad 
Published: June 2021

The anxiety of being treated differently unlike others is one of the myriad uncomfortable feelings which may be understood by cancer sufferer. The present study aimed to expose the needs of two cancer sufferers who loved each other. They are the main characters of the Fault in Our Stars namely Hazel and Augustus. Therefore, the researchers addressed two questions: How are the love and belonging needs of Hazel and Augustus portrayed in John Green's The Fault in Our Stars? And what are the impacts of fulfilling love and belonging needs toward Hazel and Augustus as it is portrayed in John Green’s novel The Fault in Our Stars? This study applied a qualitative approach namely content analysis. The data were analyzed and interpreted by using the hierarchy of needs which focused on love and belonging needs. The result exposed that Hazel and Augustus yearn for fulfilling their love and belonging needs instead of the other needs such as physiology, safety, self-esteem, and self-actualization. It affected significantly to their life which changed them to be more optimistic.
DESSECAÇÃO DA CULTURA DO FEIJÃO ATRAVÉS DE HERBICIDAS VISANDO A ANTECIPAÇÃO DE COLHEITA
Authors: Da Silva Paulo Vinicius , Carvalho Ronchi Filho Paulo César , Vieira dos Santos Paulo Henrique , Moraes Nagilla , Monquero Patricia Andrea , Dias Roque , TRONQUINE Sergio , Betito Buzzato Alessandro Carlos 
Published: June 2021

A utilização de herbicidas visando a dessecação de culturas agrícolas, especialmente na produção de grãos, trata-se de uma prática recorrente, pois possibilita a antecipação da colheita, o que pode resultar em ganhos financeiros e/ou vantagens em relação a logística de produção. Diante do exposto o presente trabalho teve como objetivo avaliar a eficácia e viabilidade de dois métodos de dessecação da cultura do feijão, através dos seguintes objetivos específicos: (a) Analisar a qualidade dos grãos de feijão após a dessecação e (b) A viabilidade econômica da antecipação da colheita. Para tal realizou-se um experimento em campo em delineamento inteiramente casualizado (DIC), com 6 tratamentos: diquat (450 g i.a./ ha-1), glufosinato de amônio (550 g i.a./ha-1), paraquat (450 g i.a./ha-1), glifosato (960 g i.a./ ha-1), dessecação em terreno e testemunha. Os parâmetros avaliados foram: Qualidade da Dessecação; Velocidade da Dessecação; Viabilidade de Custo da Dessecação, Porcentagem de Germinação, Comprimento do Hipocótilo e Peso de 100 sementes. O herbicida diquat apresentou o melhor desempenho no que tange a antecipação da colheita, 29 dias, sendo que o valor da saca nesse período era de R$ 450,00, em contrapartida o glifosato culminou no menor período de antecipação da colheita, apenas 7 dias. O paraquat foi o tratamento que melhor preservou as características fisiológicas das sementes
Bioherbicidal Potential of Eucalyptus and Clove Oil and their Combinations on Four Weedy Species
Authors: Almarie Ahmed 
Published: June 2021

Essential oils of eucalyptus leaves and clove buds were isolated and tested for their bioherbicidal potential on different annual weed species. Gas Chromatography-Mass Spectrophotometry analysis (GC-MS) identified thirteen compounds representing around 87.11% of the total isolated eucalyptus oil. The main constituent was 1,8-cineole, which accounted for 68.15% of the total identified compounds. As for clove oil, eleven compounds were identified, representing 90.03% of the total compounds. Eugenol was the dominant compound and accounted for 73.89%. The bioherbicidal efficacy of the two oils and their combinations by three concentrations (2.5, 5, and 10%) were tested on four weedy species, namely Chenopodium album, Raphanus raphanistrum, Melilotus indicus, and Sisymbrium irio. The isolated oils significantly affected the dry weight and inhibited the seedling growth of the four weedy species. Using the two essential oils, individually or within their combinations, showed the highest bioherbicidal efficacy against the targeted weeds in comparison with the synthetic herbicide. In addition, utilization of the two essential oils as natural bioherbicides caused an electrolyte leakage as a result of membrane disruption and loss of integrity of weed seedling tissues. The results showed the possibility of using eucalyptus and clove essential oils individually or in combination as a desirable alternative to synthetic herbicides for sustainable weed management.