bluuebunny/crossref_metadata_2025_split huggingface dataset:
Выбор граничных условий при моделировании процесса сортовой прокатки
Authors: Shtoda M. M. 
Published: July 2021

Штода М. Н. Выбор граничных условий при моделировании процесса сортовой прокатки. Обработка материалов давлением. 2020. № 1 (50). С. 77-82.
Целью данной работы является определение адекватного закона трения, описывающего контактные условия в очаге деформации при моделировании в программном продукте QForm 9.0.7 процесса прокатки свинцовых образцов в калибрах простой формы, так как при постановке задач процессов ОМД наибольшие трудности вызывают условия на контакте обрабатываемого металла с инструментом. Для получения практических данных, которые будут основанием определения адекватных контактных условий при моделировании, на лабораторном стане в овальном калибре были прокатаны свинцовые образцы (свинец С1) круглого поперечного сечения со средним диаметром 6,62 мм. Прокатку производили на стане 210 с частотой вращения валков 100 об./мин. Для получения разных значений коэффициента трения на контакте раската с валками образцы перед прокаткой или обезжиривали, или покрывали мылом или мелом. По средним значениям, полученным при реальном процессе прокатки в лабораторных условиях, в программном продукте QForm 9.0.7 производили расчеты при разных контактных условиях. В статье показано необходимость и эффективность проведения инверсного анализа для определения граничных условий при моделировании процессов ОМД. Показано, что все законы трения, предлагаемые в программном продукте QForm, адекватно описывают характер влияния коэффициента трения на распределение течения металла в продольном и поперечном направлениях. Наибольшая точность расчетов получена при использовании закона трения Кулона, который рекомендовано использовать при моделировании процессов прокатки в программном продукте QForm. Законы трения Зибеля и Леванова для моделирования процесса прокатки в калибрах применять нельзя.
Solving a direct problem as a new method of seismic microzonation
Authors: Aleshin Alexander S. , Pogrebchenko Vladimir V. , Nikitin Sergey N. 
Published: July 2021

The article describes a new type of seismic microzonation, called the method of solving a direct problem. The main methodological technique in this case is the formation of models of the soil layer on the basis of complex engineering-geological and geophysical studies. An original computer simulation technique based on the use of a short acceleration pulse as the
initial seismic impact is proposed. In the calculations of the increment of seismic intensity, a new
formula is used that takes into account all the factors of the influence of soil properties on the
parameters of seismic impacts – seismic rigidity, water saturation, resonant effects and the
nonlinearity of the reaction of soils to strong seismic impacts. Based on the obtained data, the
models of ground layers at the construction site are mapped and the parameters of seismic
impacts that correspond to the properties of each model of ground massif are determined. The proposals presented in the article are reflected in the regulatory documents devoted to the SMZ of objects of increased responsibility and territorial planning.
Spiritualitas dan Tipe Kepribadian Berhubungan dengan Psychological Well-Being Remaja di Sekolah Menegah Pertama Yogyakarta
Authors: Hartono Burhanuddin , Saifudin I Made Moh. Yanuar 
Published: July 2021

Remaja merupakan masa penuh dengan emosi yang apabila tidak mampu mengendalikannya dapat terjerumus pada kenakalan remaja. Data menunjukkan terjadi peningkatan kenakalan remaja dari 0.40% di tahun 2014 menjadi 0.65% pada tahun 2018. Kenakalan remaja terjadi karena ketidakmampuan individu mengendalikan diri dan lingkungannya serta kesehatan mental yang terganggu. Oleh karenanya remaja perlu mendapatkan bimbingan agar tercapai psychological well-being yang tinggi. Kesejahteraan psikologis tersebut dipengaruhi oleh tipe kepribadian dan spiritualitas. Tujuan penelitian untuk mengetahui hubungan spiritualitas dan tipe kepribadian dengan psychological well-being remaja di Sekolah Menegah Pertama Yogyakarta. Desain penelitian deskriptif korelasi dengan pendekatan cross sectional. Populasi penelitian adalah remaja Sekolah Menengah Pertama di Banguntapan Bantul Yogyakarta. Teknik pengambilan sampel yang digunakan adalah proporsional random sampling didapatkan sample sebanyak 70 orang. Data dikumpulkan menggunakan kuesioner dan dianalisis menggunakan uji statistik kendal tau dengan tingkat signifikansi 5%. Spiritualitas perawat kategori rendah 36 (51%) responden, tipe kepribadian ekstrovet 39 (56%) responden dan psychological well-being rendah 37 (53%) responden. Terdapat hubungan signifikan antara spiritualitas dan psychological well-being dengan p-Value 0.000 (<0.005). Kemudian hubungan tipe kepribadian dan psychological well-being juga signifakan dengan p-Value 0.015 (<0.005).
IMPLEMENTASI BAHAN AJAR FIQIH IBADAH DALAM PENINGKATAN CAPAIAN HASIL BELAJAR MAHASISWA
Authors: Firdaus Firdaus MH 
Published: July 2021

Pembelajaran fiqh muamalah di perlukan untuk meningkatkan wawasan pengetahuan mahasiswa di bidang Hukum Ekonomi Syari’ah, sebagai landasan pokok untuk menetapkan hukum yang mengatur antara hubungan manusia dengan sesamanya, khususnya dalam masalah perekonomian. Kegiatan aktualisasi nilai-nilai keprofesian dosen berupa pembuatan buku ajar Fiqh Muamalah dapat menjadi memecah masalah peningkatan pemahaman mahasiswa pada bidang Ilmu Hukum Ekonomi Islam agar menjadi lebih praktis dan efektif . Metode penelitian dengan pendekatan Deskriptif Kualitatif yakni membangun peningkatan capaian hasil pembelajaran fiqh muamalah dengan penerapan penggunaan buku ajar fiqh muamalah produk rancangan aktualisasi dalam proses belajar mahasiswa. Hasil dari kajian ini menunjukkan bahwa 72% mampu mencapai nilai (>85); 16 % mampu mencapai nila (81-85); 4 % mampu mencapai nila (76-80); 4 % mampu mencapai nila (66-70); dan 4 % mampu mencapai nila (51-60). Dari hasil tersebut dapat disimpulkan bahwa penerapan buku ajar Fiqh Muamalah hasil kegiatan Aktualisasi dap meningkatkan capaian hasil belajar yang sangat baik pada sebagian besar mahasiswa.

Kata kunci: Buku Ajar, Fiqh Muamalah, Capaian Hasil Belajar
La investigación tecnológica en el Deming
Authors: Cevallos Veintimilla Fabiola 
Published: July 2021

Los países con mayor capacidad de investigar y generar conocimientos logran un mayor desarrollo económico y social en este mundo globalizado. La importancia que se concede al conocimiento científico y tecnológico como un marcador de desarrollo socioeconómico es creciente, el mismo que requiere de una infraestructura científica sólida, apoyo económico y político del Estado. El presente artículo recoge los resultados de la investigación del uso y manejo de la tecnología y la innovación en el Instituto Superior Tecnológico Corporativo Edwards Deming en el período 2019 – 2020, para de esta manera formar profesionales que aporten conocimientos, ideas, inventos e innovaciones. Se utiliza la investigación tecnológica que se define como útil para el apoyo y resolución de problemas, orientada a desarrollar una sociedad mejor, a través de procesos activos o convenciones tecnológicas, comprende la descripción, registro, análisis e interpretación de la naturaleza actual y la composición o procesos de los fenómenos; el enfoque se hace sobre conclusiones dominantes o sobre cómo una persona, grupo o cosa funciona en el presente; El Ecuador requiere serias y profundas transformaciones; por lo que es urgente incrementar la eficiencia en el empleo de la tecnología e innovación importada y desarrolle la propia.
El software educativo como estrategia didáctica en matemática
Authors: Roalcaba Caro Jorge Luis , Soplapuco Montalvo Juan Pedro 
Published: July 2021

La tecnología de información y comunicación constituye un medio esencial en la mejora de las prácticas educativas. El objetivo de este estudio fue realizar un resumen sobre el uso de software GeoGebra como estrategia didáctica en matemática de estudiantes del nivel secundaria. Se emplea las bases de datos de Google Académico y Scopus publicados en los últimos cinco años. Se obtuvo una muestra total de 21 artículos científicos. Para la extracción de la información en la revisión se siguió el siguiente procedimiento: Autorías y año de publicación, diseño metodológico de estudio, variables de estudio y conclusiones. Como principal resultado se ha podido observar la necesidad de implementar el software didáctico para que pueda contribuir a la mejora del rendimiento académico de matemática. Se concluye que la utilización del software Geogebra como recurso didáctico permite la mejora del aprendizaje en matemática de los estudiantes de secundaria. Se recomienda utilizar el software educativo en las sesiones de aprendizaje para que los estudiantes logren aprendizajes significativos en matemática.
MyD88-Dependent Signaling Is Required for HOIP Deficiency–Induced Autoinflammation
Authors: Wu Xin , Tang Yong , Zhang Silin , Zhao Xueqiang , Lin Xin 
Published: July 2021

Abstract
The linear ubiquitin chain assembly complex (LUBAC) plays pivotal roles in regulating lymphocyte activation, inflammation, and cell death. This is highlighted by the fact that patients with mutations in LUBAC catalytic subunit HOIP suffer from autoinflammation combined with immunodeficiency. Although defective development of T and B cells resulting from HOIP deficiency in adaptive immunity can explain immunodeficiency, the pathogenesis of autoinflammation is not clear. In this study, we found that dendritic cell (DC)–specific deletion of HOIP resulted in spontaneous inflammation, indicating the essential role of HOIP in maintaining DC homeostasis. Although HOIP deficiency in DCs did not affect TNF-α–induced NF-κB activation, it enhanced TNF-α–induced apoptosis and necroptosis. However, crossing HoipDC KO mice with TNFR1-knockout mice surprisingly could not rescue the systematic inflammation, suggesting that the autoinflammation is not due to the effect of HOIP on TNF-α signaling. In contrast, treatment of HoipDC KO mice with antibiotics reduced the inflammation, implying that TLR signaling may contribute to the inflammatory phenotype found in HoipDC KO mice. Consistently, we found that LPS induced more cell death and significantly higher levels of IL-1α and IL-1β in HoipDC KO cells. Importantly, MyD88 deficiency rescued the inflammatory phenotype in HoipDC KO mice. Together, these findings reveal the indispensable function of HOIP in maintaining DC homeostasis, and MyD88-dependent proinflammatory signal plays a substantial role in the pathogenesis of human autoinflammation associated with HOIP mutations.
Learning style and achievement in English of secondary school students: the relationship with demographic variables
Authors: Bosman Anne , Schulze Salomé 
Published: July 2021

proficiency is crucial. In South African schools, many students who study through medium of English have underdeveloped linguistic skills. Their English proficiency may improve if they are taught in consideration of their learning styles. Therefore, the main research problem of this study was: How can the teaching of English at school be enhanced in consideration of student learning style and classroom diversity? To address this question, the study investigated academic achievement in English and learning style, and their relationship with demographic variables; the differences in the learning styles of the top and the low achievers in English; and how the top-achieving students learned English in different contexts. The sample comprised 240 students enrolled at an independent school in the North-West Province of South Africa. The study implemented a mixed method research design by means of a structured questionnaire, followed by interviews with ten of the top-achieving students selected to ensure maximum diversity. The results indicated significant differences in the achievements in English and the learning styles of different student groups. The qualitative phase of the research shed light on the learning styles of the top performers in English in different contexts and sub-fields of English. Recommendations were made on how the teachers can take students’ learning styles and classroom diversity into consideration in their classroom teaching in the quest to improve academic achievement in English.
Analgesic use for carbon monoxide poisoning induced headache: A randomized, controlled, double-blind, clinical trial
Authors: Kocak Abdullah Osman , Akbas İlker 
Published: July 2021

Purpose: To compare the effectiveness of three analgesics versus placebo in the relief of carbon monoxide (CO)-induced headache in patients with CO intoxication.
Methods: This study was a prospective, randomized, double-blind and placebo-controlled trial. Patients diagnosed with CO intoxication and who had headaches were included in the study. They were divided into four groups. Patients in group 1 received 50 mg dexketoprofen i.v. in 100 mL of saline, while those in group 2 received 800 mg ibuprofen i.v. Patients in group 3 were given I g paracetamol i.v. Group 4 patients received placebo (100 mL of physiological saline. Visual analogue scale (VAS) values were recorded at onset of treatment, and subsequently at 30th, 60th, 90th and 240th min. Patients who scored 3 and below in VAS 240 were considered to have responded to treatment.
Results: A total of 168 patients completed the study. Two analgesics and placebo significantly reduced VAS 240 score (p < 0.05). However, VAS 30, VAS 60 and VAS 240 values decreased significantly in the ibuprofen group, when compared to other groups (p < 0.05). Evaluation of response to treatment revealed no significant differences amongst the groups (p = 0.313).
Conclusion: These results suggest that analgesics are not superior to oxygen therapy in the treatment of headaches caused by CO poisoning. However, ibuprofen + oxygen treatment may be applied in people who cannot tolerate headaches for a long time.
Phytochemistry and medicinal values of Mahonia bealei: A review
Authors: Kakar Mohib Ullah , Saeed Muhammad , Luo Ke , Suheryani Imran , Shuang Wu , Deng Yulin , Dai Rongji 
Published: July 2021

Purpose: To review the medicinal uses of Mahonia bealei, an important member of the genus Mahonia, with a focus on its various applications in Traditional Chinese Medicine, as well as published scientific evidence on its effectiveness.
Methods: Information in all available literature was retrieved using different search engines including NCBI, ISI Web of Knowledge and Google.
Results: Several compounds have been extracted from M. bealei. These include alkaloids, triterpenes, flavonoids, phytosterols and lignans. Traditionally, the plant is used to treat dysentery, diarrhea and inflammation. Globally, scientists have used in vitro and in vivo techniques to evaluate the usefulness of compounds extracted from M. bealei with respect to their antibacterial, anti-inflammatory, antitumor, antioxidant as well as anti-gastrin properties.
Conclusion: Different parts of this plant still remain underexplored. Moreover, comparison of the properties of the isolated compounds has not been carried out, nor are there reports on the synergistic effects of extracts of the plant. Therefore, future research to address these areas may be useful in the discovery of new therapeutic agents.
Wound-healing effect of Platycodon grandiflorus (Jacq.) extract in rats
Authors: Wang Liang , Yang Li , Yuan Gang , Hu Long-Jiao 
Published: July 2021

Purpose: To evaluate the healing effect of Platycodon grandiflorus (Jacq.). extract (PGE) on experimental burn wounds in rats.
Methods: Rats were randomly divided into four groups of eight rats each: control group, silver sulfadiazine (SSD)-treated group, moist exposed burn ointment (MEBO)-treated group and PGE-treated group. PGE, SSD and MEBO were applied topically twice daily for 7 days. SSD and MEBO were used as reference control. External observation of wound area contraction and histological analysis of wound tissues was performed respectively. The effect of PGE on matrix metalloproteases (MMPs), vascular endothelial growth factor (VEGF) and Type-III Collagen proteins of wound tissue in rats were analysed by Western blot.
Results: After 10 days of topical treatment with PGE, PGE-treated group showed faster reduction in wound area when compared with control groups (p < 0.01). Matrix metalloprotease-2 (MMP-2), matrix metalloprotease-9 (MMP-9), VEGF and type-III collagen expressions in the wound tissue increased significantly (p < 0.05) when compared with the control burn wounds. Histological results showed an overall early recovery and regeneration in PGE-treated group when compared with control group.
Conclusion: PGE possesses a significant wound-healing activity in full-thickness burn wounds in rats. Therefore, it can potentially be developed for the management of burns.
Forsythia suspensa extract has inhibitory effect on proliferation and apoptosis of A549 lung cancer cells
Authors: Zhang Wei-guo , Liu Qin , Lei Cai-peng 
Published: July 2021

Purpose: To investigate the effect of Forsythia suspensa extract (FSE) on apoptosis and proliferation in A549 human lung cancer cells.
Methods: Inverted microscope was employed to observe morphological changes in A549 cells after exposure to FSE. Trypan blue staining of living cells was used to construct the cell growth curve after treatment with varying concentrations of FSE. The influence of FSE on cell proliferation, apoptosis and cell cycle was determined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay, while protein expressions of key apoptosis-related enzymes were evaluated by immunocytochemical method.
Results: FSE inhibited the growth of A549 lung cancer cells at a concentration range of 10 - 150 μg/mL. Flow cytometry results showed that FSE induced apoptosis in A549 cells. The proportion of cells in G0/G1-phase increased significantly (p < 0.01), while the proportion of cells in S- and G2/M-phase decreased correspondingly, indicating that the cells were in G0/G1-phase arrest. Cell cycle arrest and apoptosis-inducing effect gradually rose with increase in FSE concentration. With increasing concentrations of FSE, there was also significant increase in the expressions of caspase-3 (p < 0.05), caspase-8 (p < 0.01) and caspase-9 (p < 0.05), but significant decrease in Ki-67 (p < 0.01) and p21 ras protein (p < 0.01).
Conclusion: FSE exerts significant inhibitory effect on the proliferation of A549 lung cancer cells. Therefore, the plant can potentially be developed for the treatment of lung cancer.
Ginkgetin aglycone exerts anti-osteoporotic effect via regulation of NOX4/Akt/PI3K pathway
Authors: Wu Hongliang , Dai Min , Dai Minghua , Huang Weijie 
Published: July 2021

Purpose: To investigate the protective effect of Ginkgetin aglycone (GA) on ovariectomy-induced osteoporosis in rats, as well as the mechanism of action involved.
Methods: Adult female Wistar rats (n = 40) were separated into four group: normal control, ovariectomy (OVR), 100 mg GA/kg dose, and 200 mg GA/kg dose. The rats were ovariectomized using standard procedures, except for those in normal control group. Rats in the two treatment groups received 100 or 200 mg GA/kg orally for a period of 12 weeks. Biochemical assays were performed on the urine and blood. Markers of bone formation and mediators of inflammation were assessed. Bone microarchitectural changes were examined using micro-CT scanner, while Western blotting was used to determine the expressions of NOX4, NF-κB p65, PI3K, Akt and JNK proteins in rat femurs.
Results: Phosphorus and calcium levels in the serum varied among different groups. Levels of calcium, phosphorus and creatinine decreased (p < 0.01) significantly to a greater extent in the urine of GA group than in that of OVR group (p < 0.05). Interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α) and osteocalcin (OC) levels and the activity of alkaline phosphatase (ALP) decreased more in GA group than in OVR group. In GA-treated group, bone mineral density (BMD) was enhanced in a dose dependent manner than OVR group (p < 0.05). Treatment with GA ameliorated altered bone microarchitecture in OVR rats. Treatment of osteoporotic rats with GA led to significant and dosedependent decrease in the expressions of JNK, NOX4, NF-κB p65 and PI3K, and (p < 0.05) increase in the expression of Akt in femur tissue.
Conclusion: In conclusion, result of study proves the anti-osteoporotic activity of GA is exerted via regulation of NOX4/PI3K/Akt pathway.
Analysis and comparison of optical performance and collectible solar energy between multi-sectioned compound parabolic concentrator (CPC) and restricted exit angle CPC
Authors: Paul Damasen Ikwaba 
Published: July 2021

This study was conducted to analyse and compare the optical performance and collectible solar radiation energy of two different Compound Parabolic Concentrators (CPCs): multi-sectioned CPC (hereafter called M-CPC) and restricted exit angle CPC (hereafter called R-CPC) so as to ascertain the best CPC for photovoltaics applications. For easy comparison between M-CPC and R-CPC, a standard CPC (hereafter called S-CPC) was also designed. A detailed ray trace simulation analysis was undertaken to compare ray trace diagrams, angular acceptance, optical efficiency and energy flux distribution of the three CPCs. Results indicated that the angular acceptance and optical efficiency of the three CPCs were the same (100%) between 0º and 15º incidence angles, but significantly varied above 15º. On the other hand, solar radiation distribution on the solar cell was more uniform for the M-CPC than that of S-CPC and R-CPC. In terms of annual solar radiation collection, results indicated that both S-CPC and M-CPC collected approximately the same amount of energy (49,500 W/m2). Furthermore, the energy collected by S-CPC or M-CPC was higher than that collected by R-CPC by about 23%. Therefore, based on the energy flux distribution and collectible solar radiation energy, M-CPC is the best concentrator for photovoltaics applications.
Keywords: Multi-sectioned CPC, restricted exit angle CPC, optical performance, collectible solar radiation energy
A GATE-based Monte Carlo simulation of a dual-layer pixelized gadolinium oxyorthosilicate (GSO) detector performance and response for micro PET scanner
Authors: Nkuba Leonid L , Lugendo Innocent J , Amour Idrissa S 
Published: July 2021

The purpose of this study was to simulate the GSO detector of a micro PET using GATE simulation platform. The performance and responses of the simulated GSO detector assembly were evaluated by comparing the simulated data to the experimental and XCOM data to validate the simulation platform and procedure. Based on NEMA NU-4 2008 protocols, the performance of GSO detector in terms of sensitivity was simulated and compared to the experimental data. Similarly, the GSO detector response to photons interaction was simulated and compared against the XCOM data for absorbed intensity ratio in the GSO detector and survived intensity ratio in Pb blocks. Results showed that simulated and experimental sensitivities agreed well with R2 of 0.995 and two overlapping bands at 95% confidence. An agreement with R2 of 0.972 and 0.973 as well as with overlapping bands at 95% confidence was obtained in simulated and XCOM data for absorbed and survived intensity ratio in the GSO detector and Pb blocks, respectively. The observed agreements demonstrate the accuracy of the simulation method to mimic the behaviour of the GSO detector. The validated GATE algorithm for micro PET scanner is therefore recommended for simulation and optimisation of collimator design in further studies.
Keywords: GATE simulation, Experimental data, XCOM data, GSO detector, micro PET.