bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cultural heritage adaptation is sustainable!
Authors: Sedova A 
Published: August 2021

Abstract
Sustainable development is a well-known term. Sustainable development includes development of cities and communities, industry and infrastructure, innovation and other areas, where no achievement would be possible without caring about the past – our cultural heritage. This paper explains the four-pillar principle of sustainable development of cultural heritage, where each pillar is an amalgamation of various domains. The need to pursue sustainable development of cultural heritage was pointed out in many reports by United Nations Educational, Scientific and Cultural Organization (UNESCO), International Council on Monuments and Sites (ICOMOS), Council of Europe, and others. These important organisations stress the need to preserve heritage, and adaptation is considered an effective means for it. This paper dwells on how and at which stage of cultural heritage life cycle the decision of adaptation should be taken, and what stages it should be preceded and followed by in order to ensure the said shift to sustainable development. The decision of adaptation is seen as a key milestone in the cyclical life of a heritage building, which needs to be set to guarantee the continuation of the building’s sustainable development.
An Experimental Study on heave and Uplift Behaviour of Granular Pile Anchor Foundation System
Authors: Khan Haroon Ali , Gaddam Kalpana 
Published: August 2021

Abstract
Several innovative ground improvement techniques were presented by various researchers throughout the globe for modification of the existing poor soils. Granular Pile-Anchors (GPA) were found to be more promising in resisting the heave behavior of the expansive soils in recent times. The engineering behavior of the soil can be improved by this technique apart from resting the swell. This technique is a modification on the existing granular pile technique with an anchor plate beneath the granular pile that is connected to the foundation by means of an anchor rod or cable. Numerous scale model tests were discussed in this paper to understand the heave and pull-out behavior of Granular Pile-Anchor Foundation (GPAF) system. The effect of spacing was studied by using two granular piles at varied spacing. It was observed that the swell potential was reduced to about 68.09% for 50mm dia GPA, compared to the virgin expansive soil. The swell potential was found to be further reduced at twice the diameter of the pile spacing. The pull-out capacity was found to be increased by about 393% by providing a 50mm diameter GPA in the expansive soil.
Inhibitory effects of luteolin and its derivatives on osteoclast differentiation and differences in luteolin production by Capsicum annuum varieties
Authors: Onishi Shintaro , Tebayashi Shinichi , Hikichi Yasufumi , Sawada Hiromasa , Ishii Yukiko , Kim Chul-Sa 
Published: August 2021

ABSTRACT
Luteolin, an abundant flavonoid in the leaves of Capsicum annuum, has antioxidant activity and is, thus, a key chemical for promoting plant residue utilization, especially for the development of healthcare products. We assessed the inhibitory effect of luteolin and its glycosides on osteoclastic differentiation in human cells and found that the differentiation was effectively inhibited at noncytotoxic concentrations. We also screened 47 varieties of C. annuum for the accumulation of luteolin and apigenin to determine the prevalence of luteolin in diverse cultivars and identify varieties with high and/or selective luteolin production. The glycosides of luteolin and apigenin were found in all the tested varieties, with luteolin predominant over apigenin in most varieties. The identification and characterization of highly productive varieties of C. annuum is expected to be beneficial for the effective development of useful luteolin-based products from plant residues.
ANMCO POSITION PAPER: cardio-oncology in the COVID era (CO and CO)
Authors: Bisceglia Irma , Gabrielli Domenico , Canale Maria Laura , Gallucci Giuseppina , Parrini Iris , Turazza Fabio Maria , Russo Giulia , Maurea Nicola , Quagliariello Vincenzo , Lestuzzi Chiara , Oliva Stefano , Di Fusco Stefania Angela , Lucà Fabiana , Tarantini Luigi , Trambaiolo Paolo , Gulizia Michele Massimo , Colivicchi Furio 
Published: August 2021

AbstractThe COVID-19 pandemic and its impact on patients with cancer and cardiovascular disease have confirmed the particular vulnerability of these populations. Indeed, not only a higher risk of contracting the infection has been reported but also an increased occurrence of a more severe course and unfavourable outcome. Beyond the direct consequences of COVID-19 infection, the pandemic has an enormous impact on global health systems. Screening programmes and non-urgent tests have been postponed; clinical trials have suffered a setback. Similarly, in the area of cardiology care, a significant decline in STEMI accesses and an increase in cases of late presenting heart attacks with increased mortality and complication rates have been reported. Health care systems must therefore get ready to tackle the ‘rebound effect’ that will likely show a relative increase in the short- and medium-term incidence of diseases such as heart failure, myocardial infarction, arrhythmias, and cardio- and cerebrovascular complications. Scientific societies are taking action to provide general guidance and recommendations aimed at mitigating the unfavourable outcomes of this pandemic emergency. Cardio-oncology, as an emerging discipline, is more flexible in modulating care pathways and represents a beacon of innovation in the development of multi-specialty patient management. In the era of the COVID-19 pandemic, cardio-oncology has rapidly modified its clinical care pathways and implemented flexible monitoring protocols that include targeted use of cardiac imaging, increased use of biomarkers, and telemedicine systems. The goal of these strategic adjustments is to minimize the risk of infection for providers and patients while maintaining standards of care for the treatment of oncologic and cardiovascular diseases. The aim of this document is to evaluate the impact of the pandemic on the management of cardio-oncologic patients with the-state-of-the-art knowledge about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease (COVID-19) in order to optimize medical strategies during and after the pandemic.
ANMCO POSITION PAPER: Timing of coronary angiography in non-ST-segment elevation acute coronary syndromes
Authors: Murrone Adriano , di Uccio Fortunato Scotto , Amodeo Vincenzo , Aspromonte Nadia , Caldarola Pasquale , Casella Gianni , Cipriani Manlio , De Luca Leonardo , Di Lenarda Andrea , Domenicucci Stefano , Francese Giuseppina Maura , Imazio Massimo , Roncon Loris , Urbinati Stefano , Valente Serafina , Di Pasquale Giuseppe , Gulizia Michele Massimo , Colivicchi Furio , Gabrielli Domenico 
Published: August 2021

Abstract
The European Society of Cardiology guidelines on non-ST-elevation acute coronary syndromes suggest different temporal strategies for the angiographic study depending on the risk profile. The scientific evidence underlying the guideline recommendations and the critical issues currently existing in Italy, that often do not allow either an extended strategy of revascularization within 24 h or the application of the principle of the same day transfer from a spoke to a hub centre, are analysed. The position paper focuses, in particular, on the subgroup of patients with a defined diagnosis of non-ST-elevation myocardial infarction by proposing a timing of coronary angiography/revascularization that takes into account the available scientific evidence and the organizational possibilities of a considerable part of national cardiology services.
ANMCO POSITION PAPER: Role of intra-aortic balloon pump in patients with acute advanced heart failure and cardiogenic shock
Authors: Rossini Roberta , Valente Serafina , Colivicchi Furio , Baldi Cesare , Caldarola Pasquale , Chiappetta Daniela , Cipriani Manlio , Ferlini Marco , Gasparetto Nicola , Gilardi Rossella , Giubilato Simona , Imazio Massimo , Marini Marco , Roncon Loris , Scotto di Uccio Fortunato , Somaschini Alberto , Sorini Dini Carlotta , Trambaiolo Paolo , Usmiani Tullio , Gulizia Michele Massimo , Gabrielli Domenico 
Published: August 2021

AbstractThe treatment of patients with advanced acute heart failure is still challenging. Intra-aortic balloon pump (IABP) has widely been used in the management of patients with cardiogenic shock. However, according to international guidelines, its routinary use in patients with cardiogenic shock is not recommended. This recommendation is derived from the results of the IABP-SHOCK II trial, which demonstrated that IABP does not reduce all-cause mortality in patients with acute myocardial infarction and cardiogenic shock. The present position paper, released by the Italian Association of Hospital Cardiologists, reviews the available data derived from clinical studies. It also provides practical recommendations for the optimal use of IABP in the treatment of cardiogenic shock and advanced acute heart failure.
Aging in Place Among Older Adults With Histories of Traumatic Experiences: A Scoping Review
Authors: Danielson Ramona A , Ray-Degges Susan 
Published: August 2021

Abstract

Background and Objectives
Adverse childhood and adult experiences can have far-reaching impacts and, when coupled with typical aging-related changes, may impede the achievement of a suitable person–environment fit for aging adults. The objective of our study was to determine whether extant literature connects older adults with trauma history to successfully aging in place.

Research Design and Methods
We proposed a conceptual model regarding trauma history, adaptive capacity of aging adults, and trauma-informed supports for aging in place. We conducted a scoping review using 6 databases (keywords: older adult(s), aging in place, housing, trauma), with a full review of 32 articles.

Results
Insights included: (a) Aging in place does not have to mean living in the same house over time. (b) The uncertainty of the aging process can be traumatic and can be exacerbated by previous traumatic experiences. (c) Environmental sensitivities can result from previous traumatic experiences and cause further trauma. (d) Housing precarity is a traumatic experience. (e) Permanent supportive housing is an important resource for people in crisis. (f) Community supports are critical to aging in place.

Discussion and Implications
Our review revealed insights about aging in place and trauma, but did not connect the vulnerabilities specific to aging adults with personal trauma histories to aging in place. Research is needed that confirms the relationship between history of traumatic experiences and difficulties with aging in place as well as trauma-informed approaches that can mitigate housing-related stressors and foster community-living environments that provide equitable access to aging in place.
Inhaled Corticosteroids Increase Risk of Nontuberculous Mycobacterial Lung Disease: A Nested Case-Control Study and Meta-analysis
Authors: Shu Chin-Chung , Wei Yu-Feng , Chen Kuang-Hung , Chuang Shulin , Wang Ya-Hui , Wang Cheng-Yi , Wang Hao-Chien 
Published: August 2021

Abstract
Studies on use of inhaled corticosteroids (ICS) and the risk of nontuberculous mycobacterial lung disease (NTM-LD) are limited and have some conflicting results. We recruited 1235 NTM-LD patients and found that ICS use within 1 year was associated with increased NTM-LD, and the risk increased with elevated ICS dose and cumulative duration. Discontinuation of ICS use for more than 120 days could reduce the risk of NTM-LD to an insignificant level. For NTM species, the development of NTM-LD by ICS was highest for Mycobacterium kansasii lung disease. The pooled results of the meta-analysis showed that ICS use might increase the risk of NTM-LD with dose response in medium and high dose of daily ICS. In addition, budesonide had a smaller impact on the risk of NTM-LD than other ICS medications. The present study and meta-analysis provide evidence for ICS adjustment, including dose, discontinuation effect, and medications to possibly reduce the risk of NTM-LD.
Failing Is Not an Option, It Is the Only Option: Critical Politics as a Time of Contradiction and Failure
Authors: Fisher Kathryn M , McIntosh Christopher 
Published: August 2021

AbstractQuestions regarding the political significance of international relations (IR) and how scholarly practice relates to/constitutes a political practice appear newly resonant, but are longstanding concerns. This article utilizes the growing literature on temporality within international politics to analyze the political potential of these intellectual interventions and generate new ways of framing scholarly practice. We observe two trends within the field. First, IR as a discipline remains largely—although not exclusively—imagined as an English-language discipline generated by scholars in the Global North. Each area's political discourse is currently dominated by fears surrounding foundational political and institutional change due to the rise of racialized authoritarianism within these self-imagined democratic societies. Despite these purportedly dramatic developments, there has not been a similarly dramatic shift in the scholarly relationship with politics. Scholars continue to successfully intervene in their collective presents, but scholarship itself remains oriented toward enduring claims that accumulate knowledge and resist the possibility of “failure.” This paper theorizes the temporality of critical intervention to better relate positively to the bodies that co-constitute our political present. Ultimately, this paper concludes by arguing for a reconsideration of contradiction and failure as frames for thinking scholarly practice in time.
Limited lumbopelvic mobility does not influence short-term outcomes after primary hip arthroscopy: a propensity-matched controlled study
Authors: Jimenez Andrew E , Fox James D , Miecznikowski Kara , Maldonado David R , Saks Benjamin R , Ankem Hari K , Sabetian Payam W , Lall Ajay C , Domb Benjamin G 
Published: August 2021

ABSTRACTThere is a paucity of literature investigating the effect of lumbopelvic mobility on patient-reported outcome scores (PROs) after primary hip arthroscopy. The purpose of this study was (i) to report minimum 1-year PROs in patients with limited lumbopelvic mobility (LM) who underwent primary hip arthroscopy for femoroacetabular impingement syndrome (FAIS) and (ii) to compare clinical results with a propensity-matched control group of patients with normal lumbopelvic mobility (NM). Data were reviewed for surgeries performed between November 2019 and March 2020. Patients were considered eligible if they received a primary hip arthroscopy for FAIS in the setting of LM (seated to standing change in sacral slope ≤ 10°). LM patients were propensity-matched to a control group of patients with normal lumbopelvic motion (seated to standing change in sacral slope &gt; 10°) for comparison. A total of 17 LM and 34 propensity-matched NM patients were included in the study. LM patients showed significant improvement in all outcome measures and achieved the minimum clinically important difference (MCID) and patient acceptable symptomatic state (PASS) at high rates for modified Harris Hip Score (MCID: 94% and PASS: 82%) and International Hip Outcome Tool-12 (iHOT-12; MCID: 94% and iHOT-12: 76%). When LM patients were compared to a propensity-matched control group of NM patients, they demonstrated similar postoperative PROs and rates of achieving MCID/PASS. LM patients who undergo primary hip arthroscopy may expect favorable short-term PROs at minimum 1-year follow-up. These results were comparable to a control group of NM patients.
Is there enough evidence to support hip capsular reconstruction? A systematic review of biomechanical studies
Authors: Ankem Hari K , Ouyang Vivian W , Saks Benjamin R , Jimenez Andrew E , Sabetian Payam W , Maldonado David R , Lall Ajay C , Domb Benjamin G 
Published: August 2021

ABSTRACT
The aim of this study was to review and summarize the available biomechanical data on hip capsular reconstruction to guide clinical decision-making. A literature search was completed in December 2020 using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify biomechanical cadaver studies on hip capsular reconstruction, hip capsulectomy or hip capsular defect. The investigated parameters included maximum distraction force, capsular state affecting range of motion (ROM), rotation and translation. Four studies met al. the inclusion–exclusion criteria. The median effective force for resisting maximum distraction for the reconstruction state, capsular defect state and the intact state was 171, 111 and 206 N, respectively. The defect capsule force was significantly lower (P = 0.00438) than the intact capsule force. The reconstruction state had a higher distraction force than that of the capsular defect, but due to heterogeneity, the overall effect size was not statistically significant. The capsular reconstruction state reduced excess motion and the degree of instability compared to the capsular defect state but restored the hip close to its native capsular state in the cadaveric model. When compared to capsulectomy/defect state, hip capsular reconstruction significantly improved the rotational stability and effective force at maximum distraction and minimized translation. However, no conclusions can be made regarding the most effective protocol due to the high heterogeneity between the four studies. Further biomechanical studies are needed to test various types of grafts under the same protocol.
Associations between screen time and cognitive development in preschoolers
Authors: Zhang Zhiguang , Adamo Kristi B , Ogden Nancy , Goldfield Gary S , Okely Anthony D , Kuzik Nicholas , Crozier Mitchell , Hunter Stephen , Predy Madison , Carson Valerie 
Published: August 2021

Abstract

Objectives
To examine the cross-sectional associations between screen time and cognitive development in preschoolers.

Methods
Participants were 97 preschoolers (36 to 60 months) in Alberta and Ontario, Canada in the supporting Healthy physical AcTive Childcare setting (HATCH) study. The time that children spent watching television, videos or DVDs (television time) or playing video or computer games (video game time) on a television, computer, or portable device was assessed using a parental questionnaire. Television time and video game time were summed to calculate total screen time. Adherence to the screen time recommendation (≤1 hour/day) of the Canadian 24-Hour Movement Guidelines was calculated. Expressive vocabulary and working memory were assessed using the Early Years Toolbox. Due to the distribution of working memory, it was categorized as a binary variable based on the median score. The associations between screen time and cognitive development were examined using mixed models (expressive vocabulary) or generalized mixed models (working memory).

Results
Screen time was not associated with expressive vocabulary. Preschoolers who had higher total screen time were less likely to have better working memory (OR=0.52; 95%CI:0.31, 0.88), despite the null associations for television time (P=0.155) and video game time (P=0.079). Preschoolers who met the screen time recommendation were more likely to have higher working memory capacity (OR=3.48; 95%CI:1.06, 11.47), compared to those who did not meet the recommendation.

Conclusion
Limiting total screen time to no more than one hour per day may facilitate working memory development in preschoolers. Screen time may be unrelated to expressive language development in this age group.
The impact of education inequality on rheumatoid arthritis risk is mediated by smoking and body mass index: Mendelian randomization study
Authors: Zhao Sizheng Steven , Holmes Michael V , Zheng Jie , Sanderson Eleanor , Carter Alice R 
Published: August 2021

Abstract

Objective
To estimate the causal relationship between educational attainment—as a proxy for socioeconomic inequality—and risk of RA, and quantify the roles of smoking and BMI as potential mediators.

Methods
Using the largest genome-wide association studies (GWAS), we performed a two-sample Mendelian randomization (MR) study of genetically predicted educational attainment (instrumented using 1265 variants from 766 345 individuals) and RA (14 361 cases, 43 923 controls). We used two-step MR to quantify the proportion of education’s effect on RA mediated by smoking exposure (as a composite index capturing duration, heaviness and cessation, using 124 variants from 462 690 individuals) and BMI (517 variants, 681 275 individuals), and multivariable MR to estimate proportion mediated by both factors combined.

Results
Each s.d. increase in educational attainment (4.2 years of schooling) was protective of RA (odds ratio 0.37; 95% CI: 0.31, 0.44). Higher educational attainment was also protective for smoking exposure (β = −0.25 s.d.; 95% CI: −0.26, −0.23) and BMI [β = −0.27 s.d. (∼1.3 kg/m2); 95% CI: −0.31, −0.24]. Smoking mediated 24% (95% CI: 13%, 35%) and BMI 17% (95% CI: 11%, 23%) of the total effect of education on RA. Combined, the two risk factors explained 47% (95% CI: 11%, 82%) of the total effect.

Conclusion
Higher educational attainment has a protective effect on RA risk. Interventions to reduce smoking and excess adiposity at a population level may reduce this risk, but a large proportion of education’s effect on RA remains unexplained. Further research into other risk factors that act as potentially modifiable mediators are required.
Supporting Frontline Staff During the COVID-19 Pandemic
Authors: Clements Charlotte , Barsamian Jennifer , Burnham Nicolette , Cruz Claire , Darcy Ann Marie Grillo , Duphiney Lindsay , FitzGerald Jacqueline , Holland Susan , Joyce Christine , DeSanto-Madeya Susan 
Published: August 2021

ABSTRACT:
The coronavirus disease 2019 (COVID-19) pandemic that emerged in early 2020 put unprecedented physical, mental, and emotional strain on the staff of health care organizations, who have been caring for a critically ill patient population for more than a year and a half. Amid the ongoing pandemic, health care workers have struggled to keep up with new information about the disease, while also coping with the anxiety associated with caring for affected patients. It has also been a continual challenge for nurse leaders to provide adequate support for staff members and keep them informed about frequently changing practices and protocols. In this article, nursing leaders at an academic medical center in Boston reflect on the initial COVID-19 patient surge, which occurred from March to June 2020, and identify key actions taken to provide clinical and emotional support to frontline staff who cared for these patients. Lessons learned in this period provide insight into the management of redeployed staff, use of emotional support and debriefing, and relationship between access to information and staff morale. The knowledge gained through these initial experiences has been a vital resource as health care workers continue to face challenges associated with the ongoing pandemic.