bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment outcome of oral tofacitinib and ruxolitinib in patients with alopecia areata: A systematic review and meta-analysis
Authors: Yu Da-Ae , Kim Ye Eun , Kwon Ohsang , Park Hyunsun 
Published: July 2021

Background:
Tofacitinib and ruxolitinib have been used off-label to treat alopecia areata. Although a number of case reports and small studies have been published, there are no comprehensive reviews examining the outcomes of using tofacitinib and ruxolitinib for the treatment of alopecia areata.

Aims:
The aim of the study was to examine the outcome of patients with alopecia areata treated with oral tofacitinib or ruxolitinib in previously published studies.

Methods:
A search of MEDLINE, Embase and Cochrane library was conducted. A systematic review and meta-analysis were performed focusing on the Severity of Alopecia Tool 50 achievement rate, the frequency of adverse events and recurrence after discontinuation of treatment.

Results:
A total of 1244 studies were identified of which only 12 studies met the inclusion criteria. Of the 346 patients in these 12 studies, 288 had received oral tofacitinib and 58 had received oral ruxolitinib. The overall Severity of Alopecia Tool50 achievement rate was 66% (95% confidence interval, 54%–76%). Subgroup analysis revealed that drug choice, mean age, sex ratio and alopecia areata subtype ratio did not significantly affect the treatment response. Infections and laboratory abnormalities were the most common adverse events (98 and 65 cases of 319 patients, respectively). Patients treated for more than six months had a greater frequency of laboratory abnormalities as compared to those treated for shorter durations (24% vs. 7%; P = 0.04). Recurrence of alopecia areata was observed within three months after discontinuation of treatment in the majority (74%) of patients.

Limitations:
This analysis was limited by the small number of observational studies available for review, the heterogeneity of patient characteristics and the lack of long-term data.

Conclusion:
Both oral tofacitinib and ruxolitinib are effective and well tolerated in the treatment of alopecia areata. Clinicians should be aware of the expected efficacy, adverse events and high recurrence rate of oral JAK inhibitors for alopecia areata to effectively counsel these patients before starting therapy.
Ativação popular do espaço público na América Latina - pracialidade, monumento e patrimônio-territorial
Authors: Sousa Larissa Alves de 
Published: July 2021

Este artigo tem por objetivo analisar, a partir dos espaços públicos de Camagüey (Cuba) e Goiânia (Brasil), a relação entre os sujeitos e os monumentos. Nesse sentido, a Praça Ignacio Agramonte, em Camagüey, é significativa nos aspectos culturais e arquitetônicos, bem como demanda as experiências cotidianas dos sujeitos com a figura heroica do monumento a Ignacio Agramonte. Da mesma forma, a formação da Praça do Bandeirante, em Goiânia, tem sua essência associada Ã esfera político-cultural que emerge do processo de construção da cidade e implica nas formas de socialização, logo, o monumento ao Bandeirante desperta o interesse em compreender os sentidos políticos e/ou lúdicos representados pela estátua. Metodologicamente, trata-se da ativação popular do espaço público Ã luz do patrimônio-territorial, reforçando essa busca pela compreensão de usos e funções nos/dos espaços públicos das cidades latino-americanas e as possibilidades nas relações destes com os monumentos.
Free-floating thrombus and a fragment of atherosclerotic plaque in the lumen of the internal carotid artery – review of 2 cases
Authors: Konotopchyk S.V. , Rzayeva F.H. , Pastushyn O.A. , Nosenko N.M. , Svyrydiuk O.Ye. , Mamonova M.Yu. , Al-Kashkish I.I. 
Published: July 2021

Free-floating thrombus or a fragment of atherosclerotic plaque (mobile plaque) in the lumen of the carotid artery is extremely rare. Atherosclerosis is the most common cause underlying their occurrence. The optimal treatment strategy has not been developed, at least in part due to the rarity of observations, as well as the lack of comparative studies between conservative and surgical treatment (carotid artery stenting, endovascular thrombectomy, endarterectomy). We present two cases that demonstrate the treatment tactics of these rather rare pathologies. Patient Yu., 62 years old, was hospitalized with focal neurological symptoms, National Institutes of Health Stroke Scale of 12. According to the CT of the brain, signs of an ischemic stroke in the right middle cerebral artery circulation were detected. Selective cerebral angiography diagnosed thrombosis of the arteries of the precentral and central sulcus of the right middle cerebral artery, critical stenosis of the mouth of the right internal carotid artery, and a free-floating thrombus in its lumen with a fixation point at the level of atherosclerotic plaque, which blocked the lumen of the artery by more than 60 %. Endovascular aspiration of a free-floating thrombus was performed, followed by angioplasty and stenting of critical stenosis with a favorable clinical outcome. Patient L., 73 years old, applied for carotid ultrasonography, during which a mobile atherosclerotic plaque was diagnosed at the level of the bifurcation of the right common carotid artery. Digital selective cerebral angiography confirmed a plaque fragment floating in the lumen of the artery. After applying a loading dose of ticagrelor without complications, an emergency implantation of a carotid stent was performed at the level of the bifurcation of the right common carotid artery.Taking into account the modern possibilities of interventional radiology and a wide range of tools, the endovascular approach to the treatment of complicated atherosclerotic plaque with a floating component or a formed blood clot is the best treatment option with a good safety profile.
Pengaruh Rasio Profitabilitas dan Rasio Likuiditas terhadap Peringkat Sukuk Korporasi Perusahaan Periode 2015-2018
Authors: Widyawati Ofi Maulidya , Nurhayati  , Nurcholisah Kania 
Published: July 2021

Abstract. This study aims to determine the effect of profitability ratios and liquidity ratios on sukuk ratings for the 2015-2018 period. The sukuk rating of a company can be seen from the performance performed by the company. To measure the company's performance in this study using profitability ratios and liquidity ratios. Profitability ratio is a ratio to measure the efficiency of a company and the company's ability to generate profits. While the liquidity ratio is a ratio to measure the company's ability to meet its short-term obligations. This research is included in a quantitative descriptive study with companies listed on the Indonesia Stock Exchange (IDX) and sukuk rating agencies in Indonesia (PEFINDO) as populations. The analysis technique used in this study is multiple regression analysis. The results of this study are that profitability ratios and liquidity ratios have a simultaneous effect on sukuk ratings, profitability ratios affect sukuk ratings, and liquidity ratios affect sukuk ratings. This can be seen from the results of the t test which showed a sig value of 0.002 < 0.05 and 0.000 < 0.05.
Abstrak. Penelitian ini bertujuan untuk mengetahui pengaruh rasio profitabilitas dan rasio likuiditas terhadap peringkat sukuk tahun periode 2015-2018. Peringkat sukuk suatu perusahaan dapat dilihat dari kinerja yang dilakukan oleh perusahaan. Untuk mengukur kinerja perusahaan tersebut pada penelitian ini menggunakan rasio profitabilitas dan rasio likuiditas. Rasio profitabilitas adalah rasio untuk mengukur efisiensi perusahaan dan kemampuan perusahaan dalam menghasilkan laba. Sedangkan rasio likuiditas adalaha rasio untuk mengukur kemampuan perusahaan dalam memenuhi kewajiban jangka pendeknya. Penelitian ini termasuk dalam penelitian deskriptif verifikatif dengan pendekatan kuantitatif dengan perusahaan yang terdaftar dalam Bursa Efek Indonesia (BEI) dan lembaga pemeringkat sukuk di Indonesia (PEFINDO) sebagai populasi. Teknik analisis yang digunakan dalam penelitian ini adalah analisis regresi berganda. Hasil dari penelitian ini adalah bahwa rasio profitabilitas dan rasio likuiditas berpengaruh secara simultan terhadap peringkat sukuk, rasio profitabilitas berpengaruh terhadap peringkat sukuk, dan rasio likuiditas berpengaruh terhadap peringkat sukuk. Ini dapat terlihat dari hasil uji t yang memperlihatkan nilai sig sebesar 0,002 < 0,05 dan 0,000 < 0,05.
Analisis Penerapan Just In Time (JIT) dalam Meningkatkan Efesiensi Biaya Produksi
Authors: Purnamasari Meika , Nurleli  , Fitriah Epi 
Published: July 2021

Abstract. Just In Time is a system designed to get good quality, get costs, and achieve time and cost as efficiently as possible by eliminating existing waste. This research was carried out in the Forging, Cast and Railroad Division of PT PINDAD (Persero) Bandung, aimed at understanding the timely application of production activities and analyzing the application of just in time to improve production cost efficiency. The method of data collection is done by observing the collected objects. The data analysis technique used is a qualitative descriptive analysis technique. The results of this study indicate that the purchasing system implemented in 2013 is still ineffective, because it still uses a system that uses traditional methods that cause waste of costs and storage space. The company PT PINDAD (Persero) Bandung after implementing a timely production system on one of the products, entered into an agreement with the supplier regarding the quality, quantity, and time of delivery of raw materials by making an agreement with a supplier of the company to minimize production costs. In conducting production activities, the company gets 93.11% and efficiency levels increase by 5% so that these activities can be said to be efficient.
Abstrak. Just In Time adalah suatu sistem yang dirancang untuk mendapatkan kualitas yang baik, menekan biaya, dan mencapai waktu dan biaya seefisien mungkin dengan menghilangkan pemborosan yang ada. Penelitian ini dilakukan di Divisi Tempa, Cor dan Alat Perkeretaapian PT PINDAD (Persero) Bandung, bertujuan untuk mengetahui penerapan Just In Time dalam aktivitas produksi serta menganalisis penerapan Just In Time dalam meningkatkan efisiensi biaya produksi. Metode pengumpulan data dilakukan dengan melakukan observasi pada objek yang diteliti. Teknik analisis data yang digunakan adalah teknik analisis secara deskriptif kualitatif. Hasil penelitian ini menunjukkan bahwa sistem pembelian secara tradisional yang diterapkan pada tahun 2013 masih belum efektif, karena masih menggunakan sistem secara pendekatan tradisonal yang menyebabkan pemborosan biaya dan ruang penyimpanan. Perusahaan PT PINDAD (Persero) Bandung setelah menerapkan sistem produksi secara Just In Time pada salah satu produk, mengadakan kesepakatan dengan pemasok mengenai kualitas, jumlah, dan waktu pengiriman bahan baku dengan adanya kesepakatan dengan pemasok perusahaan dapat meminimalisir biaya produksi. Dalam melakukan aktivitas produksi, perusahaan mendapatkan aktivitas nilai tamba sebesar 93,11% dan tingkat efisiensi meningkat sebesar 5% sehingga aktifitas tersebut dapat dikatakan efisien.
Analisis Kinerja Keuangan dan Biaya Operasional pada Perusahaan Financial Technology
Authors: Febryanti Syelpia , Fadilah Sri , Nurcholisah Kania 
Published: July 2021

Abstract. The purposes of this study is to analyze financial performance and operating expenses company of fintech is a PT Kioson Komersial Tbk. from 2017 and 2018. The data used secondary data from financial statements and annual report. The research method used is descriptive qualitative. Result of the analysis are generally based on financial ratio of a liquidity ratio is in good shape is a cash turnover and inventory net working capital. Solvency ratio which is in good condition just ratio long term debt to equity ratio, while other ratios are not good is debt ratio, debt to equity ratio, and times interest earned. For activity ratio in a good condition are inventory turnover, total assets turnover, fixed assets turnover, while working capital turnover still below the industry standard. profit margin, roi, roe, except earning per share, because there is no general standard for eps. For the result of operating espenses, costs or operating expenses can affect the decrease of profit.
Abstrak. Penelitian ini ditujukan untuk menganalisis kinerja keuangan dan biaya operasional pada perusahaan Financial technology yaitu PT Kioson Komersial Tbk. pada periode tahun 2017 dan 2018. Data yang digunakan adalah data sekunder yang bersumber dari laporan keuangan dan annual report. Metode penelitian yang digunakan adalah kualitatif deskriptif. Hasil analisis secara umum berdasarkan rasio keuangan yaitu rasio likuiditas dalam keadaan baik rasio perputaran kas dan inventory net working capital. Rasio solvabilitas yang dikatakan baik hanya rasio long term debt to equity ratio, sedangkan sisanya dikatakan tidak baik seperti rasio utang, debt to equity ratio, dan times interest earned. Untuk rasio aktivitas yang baik adalah perputaran persediaan, perputaran total aktiva, dan perputaran aktiva tetap, sedangkan perputaran modal kerja masih berada di bawah standar industri. Selanjutnya rasio profitabilitas semuanya masih berada di bawah standar industri seperti rasio gross profit margin, net profit margin, roi, roe, kecuali earning per share, karena tidak ada standar yang menentukan besaran earning per share. Untuk hasil analisis biaya operasional, biaya-biaya atau beban usaha yang meningkat dapat memengaruhi laba menjadi turun.
Pengaruh Akuntansi Dana Desa dan Partisipasi Masyarakat terhadap Pengelolaan Dana Desa
Authors: Pratiwi Yustin Novia , Fadilah Sri , Nurcholisah Kania 
Published: July 2021

Abstract. Today village funds are one of the topics being discussed hotly, in their implementation of the many deviations of priority development funds carried out because they increase understanding of village funds and increase community participation in village fund management. This research was made with the aim to study the effect of village funds and community participation on village fund management. The test tool in this study is a simple and multiple linear regression analysis using SPSS software. This research uses quantitative methods using surveys. In this study, the technique used in collecting data consisted of 62 questionnaires distributed by 62 people to villages and village communities in the area of West Bandung Regency. The results show that the village financial statements have gone well against the system, community participation has gone well and involves accounting of village funds and community participation in the management of village funds.
Abstrak. Dewasa ini dana desa adalah salah satu topik yang sedang hangat dibicarakan, pada pelaksanaanya seringkali banyak penyimpangan dana maupun prioritas pelaksanaan pembangunan yang terjadi karena kurangnya pemahaman atas akuntansi dana desa dan kurangnya partisipasi masyarkat dalam pengelolaan dana desa. Penelitian ini dibuat dengan tujuan untuk mengetahui pengaruh akuntansi dana desa dan partisipasi masyarakat terhadap pengelolaan dana desa . Alat uji dalam penelitian ini ialah analisis regresi linier sederhana dan berganda dengan menggunakan software SPSS. Penelitian ini menggunakan metode kuantitatif dengan pendekatan survey . Dalam penelitian ini, teknik yang digunakan dalam pengumpulan data berupa kuisioner yang disebarkan sebanyak 62 kepada para aparatur desa dan masyarakat desa di wilayah Kabupaten Bandung Barat . Hasil penelitian menunjukan bahwa pada umumnya akuntansi dana desa sudah berjalan dengan baik disertai dengan sistemnya, partisipasi masyarakat sudah berjalan dengan baik dan terdapat pengaruh akuntansi dana desa dan partisipasi masyarakat terhadap pengelolaan dana desa.
Uji Efektivitas Ekstrak Etanol Daun Angsana (Pterocarpus Indicus Willd) sebagai Biolarvasida terhadap Larva Nyamuk Culex Sp.
Authors: Abdurrozak Mohammad Ihsan , Syafnir Livia , Sadiyah Esti Rachmawati 
Published: July 2021

Abstract. Mosquitoes are often associated with health problems because mosquito bites not only cause itching but some species can also transmit various types of parasites that are harmful to human health. One of them is Culex sp mosquito which is a class of infectious insects (vectors). This study aimed to test the activity of compounds in angsana leaf extract (Pterocarpus indicus Willd) as biolarvasides on Culex sp. mosquitoes and determine the concentration of LC50 value needed. Extraction was carried out by maceration method using 70% ethanol solvent. The extract collected was then tested biolarvaside activity on Culex sp. The study subjects were divided into 8 treatment groups, namely aquades (negative control), 0.05%, 0.1%, 0.2%, 0.5%, 1%, 2% and ABATE 0.1% (positive control). Each group contained 20 mosquito larvae with three replications (triplo). Observations were made for 24 hours at intervals of 1 hour, 4 hours, 8 hours, 12 hours and 24 hours. The biolarvaside activity of angsana leaf extract was analyzed using the probit method. Based on the results of the Probit analysis, the LC50 value was 0.83%. These results indicate that the angsana leaf extract (Pterocarpus indicus Willd) was effective as a biolarvaside.
Abstrak. Nyamuk sering dikaitkan dengan masalah kesehatan karena gigitan nyamuk tidak hanya menimbulkan gatal saja tetapi beberapa spesies nyamuk juga dapat menularkan berbagai jenis parasit yang berbahaya bagi kesehatan manusia. Salah satunya yaitu nyamuk Culex sp yang merupakan golongan serangga penular (vektor). Penelitian ini bertujuan untuk pengujian aktivitas senyawa dalam ekstrak daun angsana (Pterocarpus indicus Willd) sebagai biolarvasida pada nyamuk Culex sp dan penentuan nilai LC50. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 70%, Ekstrak yang diperoleh kemudian diuji aktivitas biolarvasida pada nyamuk Culex sp. Subjek penelitian dibagi menjadi 8 kelompok perlakuan, yaitu akuades (kontrol negatif), 0,05%, 0,1%, 0,2%, 0,5%, 1%, 2% dan ABATE 0,1% (kontrol positif).Setiap kelompok berisi 20 ekor larva nyamuk dengan tiga kali pengulangan (triplo) . Pengamatan dilakukan selama 24 jam dengan interval 1jam, 4jam, 8jam, 12jam dan 24jam. Aktivitas biolarvasida ekstrak daun angsana dianalisis dengan menggunakan metode probit. Berdasarkan hasil analisis Probit didapatkan nilai LC50 berada pada konsentrasi 0,83%.Hasil tersebut menunjukkan bahwa Ekstrak daun angsana (Pterocarpus indicus Willd) efektif sebagai biolarvasida.
Formulasi Sediaan Cuka Buah Kopi Menggunakan Ragi (Saccharomyces cerevisiae) dan Bakteri (Acetobacter aceti)
Authors: R Fathan Said , Darma Gita Cahya Eka , Kodir Reza Abdul 
Published: July 2021

Abstract. Indonesia is the third largest coffee producing country in the world, with a variety of compounds that are beneficial to the body. Vinegar fermentation is one way to add value to the benefits of fruits and vegetables because it can form useful new chemical compounds. Vinegar has a variety of benefits that have been studied such as reducing hyperglycemia, hyperinsulinemia, hyperlipidemia and obesity. Previous research in 2013 had made acetic acid from Arabica coffee pulp waste. This study aims to obtain a coffee fruit vinegar formula that conforms to the quality standards of acetic acid SNI 01-4371-1996. The material used is whole coffee with a two-stage fermentation method, namely alcohol fermentation using S. cerevisiae for 4 days and vinegar fermentation using A. aceti for 3 days. The results showed that the formula with 25% coffee fruit and 20% sugar is the best formula compared to other formulas with organoleptic test results in brown, sour and sweet taste and a little distinctive aroma of coffee, 5.03% acetic acid content, 0% alcohol content, pH 3,242.
Abstrak. Indonesia merupakan negara ketiga penghasil kopi terbesar di dunia, dengan berbagai kandungan senyawa yang bermanfaat bagi tubuh. Fermentasi cuka merupakan salah satu cara untuk menambah nilai manfaat dari buah dan sayur karena dapat membentuk senyawa kimia baru yang bermanfaat. Cuka memiliki berbagai manfaat yang telah diteliti seperti menurunkan hiperglikemia, hiperinsulinemia, hiperlipidemia dan obesitas. Penelitian sebelumnya pada tahun 2013 telah dilakukan pembuatan asam asetat dari limbah cair kulit kopi arabika. Penelitian ini bertujuan untuk mendapatkan formula cuka buah kopi yang sesuai standar mutu asam asetat SNI 01-4371-1996. Bahan yang digunakan adalah buah kopi secara utuh dengan metode fermentasi dua tahap yaitu fermentasi alkohol menggunakan S. cerevisiae selama 4 hari dan fermentasi cuka menggunakan A. aceti selama 3 hari. Hasil penelitian menunjukan bahwa formula dengan 25% buah kopi dan 20% gula merupakan formula terbaik dibandingkan dengan formula lain dengan hasil uji organoleptis berwarna coklat, rasa asam dan manis serta sedikit aroma khas kopi, kadar asam asetat 5,053%, kadar alkohol 0%, pH 3,242.
Permintaan Wisata Kelompok Pemuda ke Kota Bandung
Authors: Ayu Julida Yanti  , Sundaya Yuhka , Haviz Meidy 
Published: July 2021

Abstract. This paper presents the results of research on tourist demands to the city of Bandung. The research objective is to study the demand function of tourists in the city of Bandung. Looking at the qualitative nature of tourism demand, this study examines it through the ordered logit model. Data obtained mainly from tourists visiting the city of Bandung. The estimation model repeatedly shows five factors that explain tourism demand, namely income, travel distance, leisure time owned by tourists, vehicles used to visit the city of Bandung, and the level of congestion in the city of Bandung. The biggest model coefficient is the comfort variable. Increasing leisure time one day will increase the chances of frequent categories of visits to the city of Bandung, 24,278 times greater than other categories. Klasifikasi JEL : Q21, Z23, C19

Abstrak. Makalah ini menyajikan hasil penelitian skripsi tentang permintaan wisatawan ke Kota Bandung. Tujuan penelitiannya adalah untuk mempelajari fungsi permintaan wisatawan di Kota Bandung. Melihat sifat kualitatif dari permintaan pariwisata, penelitian ini mengkajinya melalui model logit yang dipesan. Data diperoleh terutama dari wisatawan yang mengunjungi Kota Bandung. Model hasil estimasi berulang kali menunjukkan lima faktor yang menjelaskan permintaan pariwisata, yaitu pendapatan, jarak perjalanan wisata, waktu luang yang dimiliki oleh wisatawan, kendaraan yang digunakan untuk mengunjungi Kota Bandung, dan tingkat kemacetan di Kota Bandung. Koefisien model terbesar adalah variabel waktu luang. Menambah waktu luang suatu hari, akan memperbesar peluang kategori sering berkunjung ke Kota Bandung, 24.278 kali lebih besar dari kategori lainnya. Klasifikasi JEL : Q21, Z23, C19