bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EFFECT OF LEARNING FACILITIES, LEARNING INTERESTS AND LEARNING DISCIPLINES ON STUDENT LEARNING OUTCOMES IN ACCOUNTING COMPUTER STUDY IN SMK NEGERI KOTA KENDARI
Authors: Junisba Junisba , Turi La Ode 
Published: November 2021

Tujuan penelitian ini adalah untuk menganalisis dan mendeskripsikan pengaruh: (1) fasilitas belajar terhadap hasil belajar siswa kelas XIA program keahlian akuntansi pada mata pelajaran komputer akuntansi di SMK Negeri Kota Kendari; (2) minat belajar terhadap hasil belajar siswa kelas XIA program keahlian akuntansi pada mata pelajaran komputer akuntansi di SMK Negeri Kota Kendari; (3) disiplin belajar terhadap hasil belajar siswa kelas XIA program keahlian akuntansi pada mata pelajaran komputer akuntansi di SMK Negeri Kota Kendari; (4) fasilitas belajar, minat belajar dan disiplin belajar secara simultan terhadap hasil belajar siswa kelas XIA program keahlian akuntansi pada mata pelajaran komputer akuntansi di SMK Negeri Kota Kendari. Penelitian ini merupakan penelitian kuantitatif dengan metode survei. Populasi adalah siswa SMKN Kota Kendari berjumlah 217 siswa, yang terdiri dari siswa SMKN 1 Kendari berjumlah 189 siswa, siswa SMKN 6 Kendari berjumlah 28 siswa dan sampel berjumlah 141 siswa yang terdiri dari siswa SMKN 1 Kendari berjumlah 123 siswa, siswa SMKN 6 Kendari berjumlah 18 siswa. Pengumpulan data menggunakan kuesioner instrumen variabel fasilitas belajar, instrumen variabel minat belajar, instrumen variabel disiplin belajar dan variabel hasil belajar siswa menggunakan nilai ulangan semester genap tahun pelajaran 2019/2020. Teknik analisis data menggunakan analisis deskriptif, uji prasyarat analisis dan uji hipotesis. Penelitian ini menemukan bahwa: (1) terdapat pengaruh positif dan signifikan fasilitas belajar terhadap hasil belajar belajar siswa program keahlian akuntansi kelas XIA pada mata pelajaran komputer akuntansi di SMK Negeri Kota Kendari; (2) terdapat pengaruh positif dan signifikan minat belajar terhadap hasil belajar siswa program keahlian akuntansi kelas XIA pada mata pelajaran komputer akuntansi di SMK Negeri Kota Kendari; (3) terdapat pengaruh positif dan signifikan disiplin belajar terhadap hasil belajar siswa program keahlian akuntansi kelas XIA pada mata pelajaran komputer akuntansi di SMK Negeri Kota Kendari,; (4) terdapat pengaruh positif dan signifikan fasilitas belajar, minat belajar dan disiplin belajar secara simultan terhadap hasil belajar siswa program keahlian akuntansi kelas XIA pada mata pelajaran komputer akuntansi di SMK Negeri Kota Kendari
STRATEGI PENINGKATAN PAJAK REKLAME, PAJAK RESTORAN, DAN PAJAK HOTEL DI KABUPATEN KOLAKA (STUDI KASUS BADAN PENDAPATAN DAERAH KABUPATEN KOLAKA)
Authors: Amir Amir , Amir Muhammad , Basri Muhammad 
Published: November 2021

Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis strategi peningkatan pajak reklame, pajak restoran dan pajak hotel di Badan Pendapatan Daerah Kabupaten Kolaka. Penelitian ini menggunakan pendekatan kualititf dengan informan berjumlah sebanyak 6 orang yang ditentukan secara purposive sampling. Data dalam penelitian ini diperoleh melalui wawancara mendalam dan dokumentasi, Teknik analisis data yang digunakan adalah analisis kualitatif model interaktif yang mencakup pengumpulan data yang terintegrasi dengan reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa strategi peningkatan pajak reklame, pajak restoran, dan pajak hotel di Bapenda Kabupaten Kolaka yakni strategi berbasis demokrasi dan akuntabilitas yang mencakup penemuan, penilaian, pembebanan, sensitisasi, pengumpulan, dan kepatuhan, namun strategi-strategi tersebut seluruhnya belum terimplementasi secara optimal dan komprehensif. Kata Kunci: Strategi, Peningkatan, Pajak Daerah
ANALISIS KINERJA FASILITATOR PROGRAM BANTUAN STIMULAN PERUMAHAN SWADAYA MASYARAKAT DI KECAMATAN TINANGGEA
Authors: Bachri Asbul , Kadir H. Abdul , Rahman Rahman 
Published: November 2021

Penelitian ini bertujuan untuk mengetahui dan menganalisis kinerja fasilitator program Bantuan Stimulant Perumahan Swadaya Masyarakat di Kecamatan Tinanggea Kabupaten Konawe Selatan , Penelitian ini menggunakan pendekatan kualitatif deskriptif, dengan teknik analisis data terdiri dari pengumpulan data, reduksi data, penyajian data , dan penarikan kesimpulan/verivikasi, informan didalam penelitian ini berjumlah 13 orang yang ditentukan secara purposive sampling, Hasil penelitian menunjukan bahwa Fasilitator program bantuan stimulant perumahan Swadaya di Kecamatan Tinanggea, didalam melaksanakan tugas dan fungsinya untuk melaksanakan sosialisasi, menyeleksi calon penerima BSPS, melaksanakan pendampingan dan menyusun laporan kegiatan, setelah ditinjau berdasarkan instrument penelitian menunjukan bahwa kinerja tenaga fasilitator lapangan yang bertugas di Kecamatan Tinanggea belum efektif secara menyeluruh, dari aspek kualitas kerja (Quality of work) masih belum efektif, dari aspek ketepatan waktu (Pomptness) telah cukup efektif , dari aspek inisiatif (Initiative) masih belum efektif, aspek kemampuan (capability) masih belum efektif, dan aspek komunikasi (Communication) masih belum efektifKata Kunci : Kinerja , Fasilitator
PENERAPAN DIGITALISASI DALAM PENGADAAN BARANG DAN JASA PADA SEKRETARIAT DAERAH KOTA KENDARI
Authors: Asprianto Asprianto , Alam Syamsul , Larisu Zulfiah 
Published: November 2021

Tujuan penelitian ini adalah untuk menganalisis faktor-faktor yang mempengaruhi penerapan sistem digitalisasi dalam pengadaan barang dan jasa pada Sekretariat Daerah Kota Kendari. Penelitian ini dilaksanakan di Unit Layanan Pengadaan Sekretariat Daerah Kota Kendari dengan menggunakan pendekatan kualitatif. Teknik penentuan informan secara purposive sampling sebanyak 10 orang dan teknik pengumpulan data melalui wawancara, pengamatan, serta studi dokumentasi. Analisis yang digunakan adalah dengan cara melakukan interpretasi terhadap data, fakta dan informasi yang telah dikumpulkan melalui pemahaman intelaktul dan pengalaman empiris. Hasil penelitian menunjukkan faktor yang mempengaruhi penerapan digitalisasi dalam pengadaaan barang dan jasa di Kota Kendari meliputi aturan, sumberdaya manusia, dan perangkat keras dan infrastruktur jaringan. Faktor sumberdaya dan perangkat keras dan infrastruktur jaringan menjadi penghambat, sedangkan aturan menjadi faktor pendukung.Kata Kunci : Penerapan Digitalisasi, Pengadaan Barang dan Jasa, Unit Layanan Pengadaan
Recurrent Wheeze Exacerbations Following Acute Bronchiolitis—A Machine Learning Approach
Authors: Makrinioti Heidi , Maggina Paraskevi , Lakoumentas John , Xepapadaki Paraskevi , Taka Stella , Megremis Spyridon , Manioudaki Maria , Johnston Sebastian L. , Tsolia Maria , Papaevangelou Vassiliki , Papadopoulos Nikolaos G. 
Published: November 2021

Introduction:Acute bronchiolitis is one of the most common respiratory infections in infancy. Although most infants with bronchiolitis do not get hospitalized, infants with hospitalized bronchiolitis are more likely to develop wheeze exacerbations during the first years of life. The objective of this prospective cohort study was to develop machine learning models to predict incidence and persistence of wheeze exacerbations following the first hospitalized episode of acute bronchiolitis.Methods:One hundred thirty-one otherwise healthy term infants hospitalized with the first episode of bronchiolitis at a tertiary pediatric hospital in Athens, Greece, and 73 age-matched controls were recruited. All patients/controls were followed up for 3 years with 6-monthly telephone reviews. Through principal component analysis (PCA), a cluster model was used to describe main outcomes. Associations between virus type and the clusters and between virus type and other clinical characteristics and demographic data were identified. Through random forest classification, a prediction model with smallest classification error was identified. Primary outcomes included the incidence and the number of caregiver-reported wheeze exacerbations.Results:PCA identified 2 clusters of the outcome measures (Cluster 1 and Cluster 2) that were significantly associated with the number of recurrent wheeze episodes over 3-years of follow-up (Chi-Squared,p&lt; 0.001). Cluster 1 included infants who presented higher number of wheeze exacerbations over follow-up time. Rhinovirus (RV) detection was more common in Cluster 1 and was more strongly associated with clinical severity on admission (p&lt; 0.01). A prediction model based on virus type and clinical severity could predict Cluster 1 with an overall error 0.1145 (sensitivity 75.56% and specificity 91.86%).Conclusion:A prediction model based on virus type and clinical severity of first hospitalized episode of bronchiolitis could predict sensitively the incidence and persistence of wheeze exacerbations during a 3-year follow-up. Virus type (RV) was the strongest predictor.
Sex-Dependent Estimation of Spinal Loads During Static Manual Material Handling Activities—Combined in vivo and in silico Analyses
Authors: Firouzabadi Ali , Arjmand Navid , Pan Fumin , Zander Thomas , Schmidt Hendrik 
Published: November 2021

Manual material handling (MMH) is considered as one of the main contributors to low back pain. While males traditionally perform MMH tasks, recently the number of females who undertake these physically-demanding activities is also increasing. To evaluate the risk of mechanical injuries, the majority of previous studies have estimated spinal forces using different modeling approaches that mostly focus on male individuals. Notable sex-dependent differences have, however, been reported in torso muscle strength and anatomy, segmental mass distribution, as well as lifting strategy during MMH. Therefore, this study aimed to use sex-specific models to estimate lumbar spinal and muscle forces during static MHH tasks in 10 healthy males and 10 females. Motion-capture, surface electromyographic from select trunk muscles, and ground reaction force data were simultaneously collected while subjects performed twelve symmetric and asymmetric static lifting (10 kg) tasks. AnyBody Modeling System was used to develop base-models (subject-specific segmental length, muscle architecture, and kinematics data) for both sexes. For females, female-specific models were also developed by taking into account for the female’s muscle physiological cross-sectional areas, segmental mass distributions, and body fat percentage. Males showed higher absolute L5-S1 compressive and shear loads as compared to both female base-models (25.3% compressive and 14% shear) and female-specific models (41% compressive and 23.6% shear). When the predicted spine loads were normalized to subjects’ body weight, however, female base-models showed larger loads (9% compressive and 16.2% shear on average), and female-specific models showed 2.4% smaller and 9.4% larger loads than males. Females showed larger forces in oblique abdominal muscles during both symmetric and asymmetric lifting tasks, while males had larger back extensor muscle forces during symmetric lifting tasks. A stronger correlation between measured and predicted muscle activities was found in females than males. Results indicate that female-specific characteristics affect the predicted spinal loads and must be considered in musculoskeletal models. Neglecting sex-specific parameters in these models could lead to the overestimation of spinal loads in females.
Effective Search of Triterpenes with Anti-HSV-1 Activity Using a Classification Model by Logistic Regression
Authors: Ogawa Keiko , Nakamura Seikou , Oguri Haruka , Ryu Kaori , Yoneda Taichi , Hosoki Rumiko 
Published: November 2021

Natural products are an excellent source of skeletons for medicinal seeds. Triterpenes and saponins are representative natural products that exhibit anti-herpes simplex virus type 1 (HSV-1) activity. However, there has been a lack of comprehensive information on the anti-HSV-1 activity of triterpenes. Therefore, expanding information on the anti-HSV-1 activity of triterpenes and improving the efficiency of their exploration are urgently required. To improve the efficiency of the development of anti-HSV-1 active compounds, we constructed a predictive model for the anti-HSV-1 activity of triterpenes by using the information obtained from previous studies using machine learning methods. In this study, we constructed a binary classification model (i.e., active or inactive) using a logistic regression algorithm. As a result of the evaluation of predictive model, the accuracy for the test data is 0.79, and the area under the curve (AUC) is 0.86. Additionally, to enrich the information on the anti-HSV-1 activity of triterpenes, a plaque reduction assay was performed on 20 triterpenes. As a result, chikusetsusaponin IVa (11: IC50 = 13.06 μM) was found to have potent anti-HSV-1 with three potentially anti-HSV-1 active triterpenes. The assay result was further used for external validation of predictive model. The prediction of the test compounds in the activity test showed a high accuracy (0.83) and AUC (0.81). We also found that this predictive model was found to be able to successfully narrow down the active compounds. This study provides more information on the anti-HSV-1 activity of triterpenes. Moreover, the predictive model can improve the efficiency of the development of active triterpenes by integrating many previous studies to clarify potential relationships.
Genome-Wide Identification of CBL-CIPK Gene Family in Honeysuckle (Lonicera japonica Thunb.) and Their Regulated Expression Under Salt Stress
Authors: Huang Luyao , Li Zhuangzhuang , Fu Qingxia , Liang Conglian , Liu Zhenhua , Liu Qian , Pu Gaobin , Li Jia 
Published: November 2021

In plants, calcineurin B-like proteins (CBLs) are a unique group of Ca2+ sensors that decode Ca2+ signals by activating a family of plant-specific protein kinases known as CBL-interacting protein kinases (CIPKs). CBL-CIPK gene families and their interacting complexes are involved in regulating plant responses to various environmental stimuli. To gain insight into the functional divergence of CBL-CIPK genes in honeysuckle, a total of six LjCBL and 17 LjCIPK genes were identified. The phylogenetic analysis along with the gene structure analysis divided both CBL and CBL-interacting protein kinase genes into four subgroups and validated by the distribution of conserved protein motifs. The 3-D structure prediction of proteins shown that most LjCBLs shared the same Protein Data Bank hit 1uhnA and most LjCIPKs shared the 6c9Da. Analysis of cis-acting elements and gene ontology implied that both LjCBL and LjCIPK genes could be involved in hormone signal responsiveness and stress adaptation. Protein-protein interaction prediction suggested that LjCBL4 is hypothesized to interact with LjCIPK7/9/15/16 and SOS1/NHX1. Gene expression analysis in response to salinity stress revealed that LjCBL2/4, LjCIPK1/15/17 under all treatments gradually increased over time until peak expression at 72 h. These results demonstrated the conservation of salt overly sensitive pathway genes in honeysuckle and a model of Ca2+-LjCBL4/LjSOS3-LjCIPK16/LjSOS2 module-mediated salt stress signaling in honeysuckle is proposed. This study provides insight into the characteristics of the CBL-CIPK gene families involved in honeysuckle salt stress responses, which could serve as a foundation for gene transformation technology, to obtain highly salt-tolerant medicinal plants in the context of the global reduction of cultivated land.
Herpes DNAemia and TTV Viraemia in Intensive Care Unit Critically Ill Patients: A Single-Centre Prospective Longitudinal Study
Authors: Mallet François , Diouf Léa , Meunier Boris , Perret Magali , Reynier Frédéric , Leissner Philippe , Quemeneur Laurence , Griffiths Andrew D. , Moucadel Virginie , Pachot Alexandre , Venet Fabienne , Monneret Guillaume , Lepape Alain , Rimmelé Thomas , Tan Lionel K. , Brengel-Pesce Karen , Textoris Julien 
Published: November 2021

IntroductionWe analysed blood DNAemia of TTV and four herpesviruses (CMV, EBV, HHV6, and HSV-1) in the REAnimation Low Immune Status Marker (REALISM) cohort of critically ill patients who had presented with either sepsis, burns, severe trauma, or major surgery. The aim was to identify common features related to virus and injury-associated pathologies and specific features linking one or several viruses to a particular pathological context.MethodsOverall and individual viral DNAemia were measured over a month using quantitative PCR assays from the 377 patients in the REALISM cohort. These patients were characterised by clinical outcomes [severity scores, mortality, Intensive Care Unit (ICU)-acquired infection (IAI)] and 48 parameters defining their host response after injury (cell populations, immune functional assays, and biomarkers). Association between viraemic event and clinical outcomes or immune markers was assessed using χ2-test or exact Fisher’s test for qualitative variables and Wilcoxon test for continuous variables.ResultsThe cumulative incidence of viral DNAemia increased from below 4% at ICU admission to 35% for each herpesvirus during the first month. EBV, HSV1, HHV6, and CMV were detected in 18%, 12%, 10%, and 9% of patients, respectively. The incidence of high TTV viraemia (&gt;10,000 copies/ml) increased from 11% to 15% during the same period. Herpesvirus viraemia was associated with severity at admission; CMV and HHV6 viraemia correlated with mortality during the first week and over the month. The presence of individual herpesvirus during the first month was significantly associated (p &lt; 0.001) with the occurrence of IAI, whilst herpesvirus DNAemia coupled with high TTV viraemia during the very first week was associated with IAI. Herpesvirus viraemia was associated with a lasting exacerbated host immune response, with concurrent profound immune suppression and hyper inflammation, and delayed return to immune homeostasis. The percentage of patients presenting with herpesvirus DNAemia was significantly higher in sepsis than in all other groups. Primary infection in the hospital and high IL10 levels might favour EBV and CMV reactivation.ConclusionIn this cohort of ICU patients, phenotypic differences were observed between TTV and herpesviruses DNAemia. The higher prevalence of herpesvirus DNAemia in sepsis hints at further studies that may enable a betterin vivounderstanding of host determinants of herpesvirus viral reactivation. Furthermore, our data suggest that EBV and TTV may be useful as additional markers to predict clinical deterioration in ICU patients.
Rapid Detection of Tomato Spotted Wilt Virus With Cas13a in Tomato and Frankliniella occidentalis
Authors: Zhang Wanhong , Jiao Yubing , Ding Chengying , Shen Lili , Li Ying , Yu Yanbi , Huang Kun , Li Bin , Wang Fenglong , Yang Jinguang 
Published: November 2021

Graphical AbstractSchematic of CRISPR/Cas13-based virus detection.
Anlotinib in Chinese Patients With Recurrent Advanced Cervical Cancer: A Prospective Single-Arm, Open-Label Phase II Trial
Authors: Zhu Jun , Song Chunyan , Zheng Zhong , Xia Lingfang , Chen Yanqiong , Ke Guihao , Wu Xiaohua 
Published: November 2021

ObjectiveThis phase II, single-arm, prospective study aimed to evaluate the efficacy and safety of anlotinib in Chinese patients with recurrent or metastatic cervical cancer (CC).MethodsPatients with histologically proven recurrent or metastatic advanced CC were enrolled at Fudan University Shanghai Cancer Center. Patients received 12 mg of oral anlotinib daily before breakfast for 2 weeks of each 3-week (21 days) cycle separated by a 1-week interval. Anlotinib was administered orally until disease progression, patient withdrawal, intolerant toxicity, or death. The primary endpoint was the objective response rate (ORR) according to the Response Evaluation Criteria in Solid Tumors, and the secondary endpoints included the disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and safety.ResultsBetween September 2018 and November 2019, 41 patients were recruited. The median age was 53 years old. The histological results revealed that 82.9% of the recruited patients had squamous cell carcinoma, 14.6% had adenocarcinoma, and 2.4% had other types. At the data cutoff date, six patients were still being treated, and 35 patients had discontinued treatment. Forty (40/41, 97.5%) patients were evaluated for treatment response. The median PFS and OS was 3.2 and 9.9 months, respectively, in patients who received anlotinib treatment. The ORR was 24.4%. In addition, 34.2% (14/41) of patients were confirmed to have stable disease, and 39.0% (16/41) of patients were confirmed to have progressive disease. The DCR was 58.5%. Ten patients (10/41) had a confirmed response during the follow-up period. Most adverse events (AEs) were grade 1 or 2. High-grade AEs (grade 3) included urinary leukocyte positivity (9.8%), hematuria (4.9%), and hypertension (2.4%).ConclusionThis is the first study to evaluate the efficacy and safety of anlotinib in Chinese patients with recurrent or metastatic CC. Anlotinib produced durable clinical responses with manageable safety in these patients.
Imaging Findings in Neonates With Congenital Pyriform Sinus Fistula: A Retrospective Study of 45 Cases
Authors: Li Li , Zhao Dong-Ji-Hui , Yao Tao-Yue , Xiang Yong-Hua , Liu Hong , Ma Qiu-Hong , Jin Ke , He Si-Ping 
Published: November 2021

Background: Congenital pyriform sinus fistula (CPSF) is a rare branchial cleft deformity. The characteristics and management of CPSF in neonates are different from those in children or adults, and a comprehensive understanding of the imaging features of neonatal CPSF can facilitate its preoperative diagnosis. Thus, the aim of this study was to summarize the ultrasonography (US) and CT imaging findings of CPSF in neonates.Methods: Forty-five full-term neonates with CPSF, confirmed by pathology after surgical resection from January 2012 to October 2020, were included in this retrospective study. All patients underwent preoperative cervical US and contrast-enhanced CT examinations, and the imaging findings were analyzed.Results: Forty-six cervical cystic masses were found in 45 neonates, including one case with bilateral lesions, three cases with lesions on the right side, and 41 cases on the left side. Both US and CT detected neck abnormality among all cases, while the diagnostic accuracy of US (15/46, 32.6%) was lower than that of CT (42/46, 91.3%). Moreover, CT showed significantly higher detection rates of intralesional air bubbles, involvement of the ipsilateral thyroid, deviation of the airway, and expansion into the mediastinal and retropharyngeal space compared with the US. As the age increased, it was more likely to present some features including the absence of air-containing, thick cyst wall, and poorly defined border (ρ &lt;0.05).Conclusion: CPSF in the neonates showed distinctive imaging findings on contrast-enhanced CT scan, which provides important supplementary information for the diagnosis of CPSF after the initial US examination.