bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of a Nomogram of In-hospital Major Adverse Cardiovascular and Cerebrovascular Events in Patients With Acute Coronary Syndrome
Authors: Bo Xiangwei , Liu Yang , Yang Mingming , Lu Zhengri , Zhao Yuanyuan , Chen Lijuan 
Published: August 2021

Background and Objective: This study aims to develop and validate a nomogram for the occurrence of in-hospital major adverse cardiovascular and cerebrovascular events (MACCE) in acute coronary syndrome (ACS) patients.Methods: A total of 1,360 ACS patients admitted between November 2014 and October 2019 from Zhongda Hospital and Yancheng Third People's Hospital were included. Patients admitted in Zhongda Hospital before 2018 were split into the training cohort (n = 793). Those admitted after 2018 in Zhongda Hospital and patients from Yancheng Third People's Hospital were split into the validation cohort (n = 567). Twenty eight clinical features routinely assessed including baseline characteristics, past medical history and auxiliary examinations were used to inform the models to predict in-hospital MACCE (all-cause mortality, reinfarction, stroke, and heart failure) in ACS patients. The best-performing model was tested in the validation cohort. The accuracy and clinical applicability were tested by the area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analyses (DCA).Results: The in-hospital MACCE occurred in 93 (6.83%) patients. The final prediction model consists of four variables: age, Killip grading, fasting blood-glucose (FBG) and whether percutaneous coronary intervention (PCI) was performed at early stage. A nomogram was used to present the final result. Individualized nomogram exhibited comparable discrimination to the Global Registry of Acute Coronary Events (GRACE) score [AUC: 0.807 (95% CI 0.736–0.878) vs. 0.761 (95% CI 0.69–0.878)], P = 0.10) and a better discrimination than the Evaluation of the Methods and Management of Acute Coronary Events (EMMACE) score [AUC: 0.807 (95% CI 0.736–0.878) vs. 0.723(95% CI 0.648–0.798), P = 0.01] in predicting the risk of in-hospital MACCE in ACS patients. A good prediction performance was maintained in the validation cohort (AUC =0.813, 95% CI 0.738–0.889). The prediction model also exhibited decent calibration (P = 0.972) and clinical usefulness.Conclusion: The nomogram may be a simple and effective tool in predicting the occurrence of in-hospital MACCE in ACS patients. Further longitudinal studies are warranted to validate its value in guiding clinical decision-making and optimizing the treatment of high-risk patients.
Interpretable Trials: Is Interpretability a Reason Why Clinical Trials Fail?
Authors: Chao Yi-Sheng , Wu Chao-Jung , Wu Hsing-Chien , McGolrick Danielle , Chen Wei-Chih 
Published: August 2021

Background: There are clinical trials using composite measures, indices, or scales as proxy for independent variables or outcomes. Interpretability of derived measures may not be satisfying. Adopting indices of poor interpretability in clinical trials may lead to trial failure. This study aims to understand the impact of using indices of different interpretability in clinical trials.Methods: The interpretability of indices was categorized as: fair-to-poor, good, and unknown. In the literature, frailty indices were considered fair to poor interpretability. Body mass index (BMI) was highly interpretable. The other indices were of unknown interpretability. The trials were searched at clinicaltrials.gov on October 2, 2018. The use of indices as conditions/diseases or other terms was searched. The trials were grouped as completed, terminated, active, and other status. We tabulated the frequencies of frailty, BMI, and other indices.Results: There were 263,928 clinical trials found and 155,606 were completed or terminated. Among 2,115 trials adopting indices or composite measures as condition or disease, 244 adopted frailty and 487 used BMI without frailty indices. Significantly higher proportions of trials of unknown status used indices as conditions/diseases or other terms, compared to completed and terminated trials. The proportions of active trials using frailty indices were significantly higher than those of completed or terminated trials.Discussion: Clinical trial databases can be used to understand why trials may fail. Based on the findings, we suspect that using indices of poor interpretability may be associated with trial failure. Interpretability has not been conceived as an essential criterion for outcomes or proxy measures in trials. We will continue verifying the findings in other databases or data sources and apply this research method to improve clinical trial design. To prevent patients from experiencing trials likely to fail, we suggest further examining the interpretability of the indices in trials.
BacAnt: A Combination Annotation Server for Bacterial DNA Sequences to Identify Antibiotic Resistance Genes, Integrons, and Transposable Elements
Authors: Hua Xiaoting , Liang Qian , Deng Min , He Jintao , Wang Meixia , Hong Wenjie , Wu Jun , Lu Bian , Leptihn Sebastian , Yu Yunsong , Chen Huan 
Published: August 2021

Graphical AbstractOverall BacAnt’s service workflow. The figure is adapted with permissions from IntegronFinder (Cury et al., 2016).
Establishment of the Radiologic Tumor Invasion Index Based on Radiomics Splenic Features and Clinical Factors to Predict Serous Invasion of Gastric Cancer
Authors: Pan Bujian , Zhang Weiteng , Chen Wenjing , Zheng Jingwei , Yang Xinxin , Sun Jing , Sun Xiangwei , Chen Xiaodong , Shen Xian 
Published: August 2021

BackgroundCurrently, there are shortcomings in diagnosing gastric cancer with or without serous invasion, making it difficult for patients to receive appropriate treatment. Therefore, we aimed to develop a radiomic nomogram for preoperative identification of serosal invasion.MethodsWe selected 315 patients with gastric cancer, confirmed by pathology, and randomly divided them into two groups: the training group (189 patients) and the verification group (126 patients). We obtained patient splenic imaging data for the training group. A p-value of &lt;0.05 was considered significant for features that were selected for lasso regression. Eight features were chosen to construct a serous invasion prediction model. Patients were divided into high- and low-risk groups according to the radiologic tumor invasion risk score. Subsequently, univariate and multivariate regression analyses were performed with other invasion-related factors to establish a visual combined prediction model.ResultsThe diagnostic accuracy of the radiologic tumor invasion score was consistent in the training and verification groups (p&lt;0.001 and p=0.009, respectively). Univariate and multivariate analyses of invasion risk factors revealed that the radiologic tumor invasion index (p=0.002), preoperative hemoglobin &lt;100 (p=0.042), and the platelet and lymphocyte ratio &lt;92.8 (p=0.031) were independent risk factors for serosal invasion in the training cohort. The prediction model based on the three indexes accurately predicted the serosal invasion risk with an area under the curve of 0.884 in the training cohort and 0.837 in the testing cohort.ConclusionsRadiological tumor invasion index based on splenic imaging combined with other factors accurately predicts serosal invasion of gastric cancer, increases diagnostic precision for the most effective treatment, and is time-efficient.
A Differentiable Extended Kalman Filter for Object Tracking Under Sliding Regime
Authors: Piga Nicola A. , Pattacini Ugo , Natale Lorenzo 
Published: August 2021

Tactile sensing represents a valuable source of information in robotics for perception of the state of objects and their properties. Modern soft tactile sensors allow perceiving orthogonal forces and, in some cases, relative motions along the surface of the object. Detecting and measuring this kind of lateral motion is fundamental to react to possibly uncontrolled slipping and sliding of the object being manipulated. Object slip detection and prediction have been extensively studied in the robotic community leading to solutions with good accuracy and suitable for closed-loop grip stabilization. However, algorithms for object perception, such as in-hand object pose estimation and tracking algorithms, often assume no relative motion between the object and the hand and rarely consider the problem of tracking the pose of the object subjected to slipping and sliding motions. In this work, we propose a differentiable Extended Kalman filter that can be trained to track the position and the velocity of an object under translational sliding regime from tactile observations alone. Experiments with several objects, carried out on the iCub humanoid robot platform, show that the proposed approach allows achieving an average position tracking error in the order of 0.6 cm, and that the provided estimate of the object state can be used to take control decisions using tactile feedback alone. A video of the experiments is available as Supplementary Material.
Endoscopic Pilonidal Sinus Treatment: A Tertiary Care Academic Center Experience
Authors: Gallo Gaetano , Carpino Antonio , De Paola Gilda , Fulginiti Serena , Novelli Eugenio , Ferrari Francesco , Sammarco Giuseppe 
Published: August 2021

Background: Pilonidal disease (PD) represents one of the most common proctological diseases in young adults. Although several approaches to treating PD have been described, there is still a lack of agreement on which is the best. The aim of this study was to evaluate the long-term efficacy of endoscopic pilonidal sinus treatment (EPSiT) at a tertiary care academic center.Methods: Between June 2017 and January 2021, a total of 32 patients [12 women (37.5%) and 20 men (62.5%)] with a mean age of 29.22 ± 12.98 years were treated with EPSiT. Pre- and post-operative symptoms were assessed with a score of 0–5. Success was defined as the absence of any subjective symptoms, as well as by complete post-operative wound healing.Results: Most of the patients had a midline external opening (17/32; 53.1%), with a mean number of external openings of 2.41 (1–4) ± 1.04. The median post-operative pain score was 0, and the mean follow-up period was 22 (4–42) ± 11.49 months. The time to wound healing was reduced in patients with one opening (28.14 ± 4.06 days) compared to patients with two or more openings (33.64 ± 7.3 days) (p = 0.067). The mean operative time was longer in patients who subsequently had a recurrence (41.75 ± 6.24 vs. 34.18 ± 6.24 min; p = 0.031). The overall success rate was 87.5% (28/32), and the mean time to recurrence was 3.25 (2–5) ± 1.26 months.Conclusions: EPSiT represents a viable option for the treatment of PD. More evidence and a longer follow-up period are needed to validate the results.
SISTEM UNDI DALAM BUDAYA DEMOKRASI: Mencari Pemimpin Gereja Dengan Perspektif Jabatan Sebagai Pemberian TUHAN.
Authors: Sipayung Gerhard 
Published: August 2021

Abstract:
Penelitian ini dilakukan untuk menjadikan sistem undi sebagai solusi dalam budaya demokrasi dalam pemilihan pemimpin rohani (Ephorus) untuk menghindari konflik kepentingan dan konflik horizontal dalam masa kepemimpinan seorang pemimpin rohani. Fakta di lapangan,budaya demokrasi dalam memilih pemimpin sinode, telah membuat para pendeta dan anggota jemaat terbelah dan terjebak mengikuti pola-pola yang dilakukan seperti dalam pemilihan kepala daerah dan pemilihan presiden. Dampak yang terjadi adalah perpecahan dalam Gereja itu sendiri sehingga terbentuk kelompok-kelompok, perebutan dan tuntutan janji “ladang basah” sebagai balas jasa dari pemimpin yang terpilih kepada tim sukses yang memenangkan pemimpin tersebut, bahkan black campaign yang mungkin saja benar dan bisa saja fitnah seperti (perdukunan dan intervensi penguasa) pra dan pasca pemilihan. Hal ini tentu membuat keresahan diantara jemaat dan hilangnya fungsi jabatan sebagai pelayan, tingkat kepercayaan jemaat kepada para pemimpin/pendeta berkurang. Jika ini dibiarkan, maka tidak ada lagi perbedaan antara Gereja dengan sekularisme dan filosofi Gereja sebagai garam dunia tidak relevan lagi. Penelitian ini menggunakan pendekatan Kualitatif dengan metode literatur/pustaka serta fakta di lapangan. Hasil dari penelitian ini menunjukkan bahwa; Pertama, Pemimpin yang terpilih dengan sistem undi haruslah pemimpin yang terlebih dahulu memenuhi standar etika dan rohani sesuai dengan kompetensi seorang pemimpin rohani. Kedua, sistem Undi dapat menghindarkan seorang pemimpin yang terpilih bertanggungjwawab hanya kepada kelompok tertentu. Ketiga, sistem Undi membentuk seorang pemimpin yang terpilih untuk menegakkan nilai-nilai Alkitab sebagai kontrol sosial baik ke dalam maupun ke luar Gereja.

Kata Kunci: Demokrasi, Jabatan, Pemberian TUHAN, Pemimpin rohani, Undi
Pengaruh Kepemimpinan terhadap Kepuasan Kerja Guru Pada SMPN 1 Banuhampu Kabupaten Agam
Authors: Husna Nikmatul 
Published: August 2021

This research was accomplished by Nikmatul Husna, 2014422030, Department of Magister
Management, 2014.2, with the title THE INFLUENCE OF LEADERSHIP TOWARD WORK
SATISFACTION IN SMPN 1 BANUHAMPU KABUPATEN AGAM.
The purpose of this research is to identify and analyze the influence of leadership toward work
satisfaction in SMPN 1 Banuhampu Kabupaten Agam. The population of the research is the teachers in SMPN
1 Banuhampu Kabupaten Agam. Samples taken are 56 respondents by using random sampling technique, which
determine samples by taking a sample randomly and use the questionnaire as a tool to collect data. Based on
hypothesis in this research, it is assumed that the influence of leadership significantly and positively influence
the teachers’ work satisfaction in SMPN 1 Banuhampu Kabupaten Agam.
The data analysis methods author used in this research are validity tes, reliability test, variable
descriptive analysis test, simple linear regression analysis, T test and F test. From analysis that have been done,
author found that leadership variable (X1) is significantly and positively influence the satisfaction of teachers’
work, this is proven by the significant probability value of leadership is resulted in 0,000 which is smaller than
0,05. From F test, it can be concluded that regression model can be use to predict the leadership which have
significantly and positively influence toward teachers’ work satisfaction by the significant probability value is
resulted in 0,000 which is smaller than 0,05.
Tahapan Implementasi Environmental Accounting Pada Universitas Di Kota Padang
Authors: Agusti Anatia 
Published: August 2021

Penelitian ini bertujuan untuk mengetahui bagaimanakah kepedulian lingkungan, keterlibatan
lingkungan, laporan lingkungan dan audit lingkungan pada universitas di kota Padang terkait tahapan
implementasi environmental accounting. Objek pada penelitian ini adalah Universitas yang ada di kota
Padang, populasi penelitian berjumlah 96 orang, adapun teknik pengambilan sampel menggunakan
purposive sampling dan penentuan jumlah sampel dengan rumus Isaac dan michael sehingga di dapat sampel
sebanyak 75 orang. Data pada penelitian ini diperoleh dengan menggunakan kuesioner dan wawancar.
Metode analisis yang digunakan dalam penelitian ini adalah statistik deskriptif, uji validitas, reliabilitas.
Hasil penelitian menunjukkan bahwa : 1) Kepedulian lingkungan oleh pihak universitas yang ada di Kota
Padang dinilai berada pada kategori kecenderungan rendah, yaitu sebesar 41% dengan responden 13 dari 32
total responden. 2) Keterlibatan lingkungan yang dilakukan oleh pihak universitas yang ada di Kota Padang
dinilai berada pada kategori kecenderungan tinggi, yaitu sebesar 44% dengan responden 14 dari 32 total
responden. 3) Pelaporan lingkungan yang dilakukan oleh pihak universitas yang ada di Kota Padang dinilai
berada pada kategori kecenderungan rendah, yaitu sebesar 56% dengan responden 18 dari 32 total
responden. 4) Audit lingkungan yang dilakukan oleh pihak universitas yang ada di Kota Padang dinilai
berada pada kategori kecenderungan rendah, yaitu sebesar 47% dengan responden 15 dari 32 total
responden. Hasil penelitian ini akan bermanfaat bagi Universitas dalam meningkatkan efektifitas
implementasi Environmental Accounting.
Analysis of Capital Relationships and Financial Statement Disclosures on the Net Profit Margin of Insurance Companies
Authors: Efriyenty Dian 
Published: August 2021

The survey results on disclosure of financial statements, there were managers who did not disclose their
intangible assets. Judging from the development of financial accounting standards No. 19 which states
that not many companies have disclosed it. The phenomenon develops along with these standards. The
research objective is to assess the intellectuals of this standard. The purpose of this study is to analyze
capital relations and disclosure of financial statements on the margin on net income. The objects of this
research are eleven insurance business units. Collecting data from reference books and journals as well
as financial statement. Analysis of the data used with the help of partial tests and concurrent testing.
Based on the processed data, relationship capital has no impact on margins. Meanwhile, disclosure of
financial statements has an impact on net income. And the results together have an effect on the margins
on net income.
Harga Saham (Studi Kausalitas Nilai Tukar Rupiah, Interest Rate, Inflasi, Dan Volume Perdagangan Saham) Pada Perusahaan Pertambangan Yang Terdaftar Di Bursa Efek Indonesia Tahun 2012-2016
Authors: Karlinda Ai Elis , Ramadhan Muhammad Fikri 
Published: August 2021

This study aims to determine the effect rupiah exchange rate, interest rate, inflation,
and trading volume on the stock price mining company partially and simultaneously. The
analytical method used is the method of multiple linear regression analysis and hypothesis
testing with stock price monthly data, the rupiah exchange rate, the interest rate, the inflation,
and the trading volume period in 2012-2016.
The results showed that : 1) the exchange rate of rupiah is partially no significant
positive effect on stock prices. 2) the interest rate is partially no significant positive effect on
stock price. 3) the Inflation is partially no significant positive effect on stock prices. 4) and the
trading volume is partially a significant positive effect on stock prices. 5) While the exchange
rate of Rupiah, interest rate, inflation, and trading volume simultaneously a significant positive
effect on stock prices of mining companies period in 2012-2016.
CCORRELAÇÕES FENOTÍPICAS E GENOTÍPICAS A EXPRESSÃO DE VINCRISTINA E VIMBLASTINA RELATIVAS AO EFEITO DO SOLO EM CARACTERÍSTICAS CONCERNENTES A CATHARANTHUS ROSEUS
Authors: Paula Felipe , Gonçalves Soares Israel Felipe , Dias de Souza Neto José , Moreira Moulin Monique , Candido Gabriel Berilli Ana Paula , De Carvalho Nascimento Larissa , Rodrigues Pretti Irany 
Published: August 2021

O Brasil possui cerca de oito mil produtores de flores e plantas. Juntos, eles cultivam mais de 350 espécies com cerca de três mil variedades. Catharanthus roseus ou popularmente conhecida como vinca é uma planta herbácea perene, nativa da ilha de Madagascar que apresenta grande versatilidade de uso para floricultura quanto para indústria farmacêutica, assim o interesse pela vinca se justifica pelo fato de que sua produção e acúmulo de alcalóides nas folhas (vimblastina e vincristina) são responsáveis pela atividade antileucêmica nos tratamentos quimioterápicos e o uso de seus metabólitos têm sido utilizados, principalmente para a fabricação de medicamentos contra o câncer. Assim, o presente artigo buscou destacar quais fatores são responsáveis pelo aumento do conteúdo de vincristina e vimblastina em C. roseus. Dessa forma, quatro variedades comerciais foram cultivadas em vasos de 5 litros, e analisadas os seus perfis morfológicos, moleculares realizados em RT-qPCR e estatísticas pelo programa GENES. Assim, os resultados permitiram identificar que a variedade Sunstorm Blush apresentou maior expressão em relação ao Latossolo B, porém, não foram detectadas diferenças estatística para os demais tratamentos e quanto maior o tamanho do diâmetro da flor maior será a expressão dos genes DAT e D4H.
La segunda generación de leyes archivísticas en México
Authors: Sánchez Espinoza Ariel , Ramírez Aceves Merizanda María del Carmen , Carreto Bernal Fernando 
Published: August 2021

En un artículo anterior se señalaron los Estados de la República Mexicana que diseñaron lo que denominamos como la primera generación de leyes archivísticas de este país por haberse creado antes de la publicación de la Ley Federal de Transparencia y Acceso a la Información Pública Gubernamental, estos fueron: Nayarit (1957), Puebla (1985), Estado de México (1986), Yucatán (1986), Tabasco (1987), Zacatecas (1987), Guerrero (1988), Veracruz (1990), Aguascalientes (1992), Chiapas (1993), Baja California Sur (1994), Sonora (1996), Jalisco (1998) y Quintana Roo (2001), que representaron tan sólo el 44% del total de entidades federativas en contar con una ley de esta naturaleza.

En contraste con lo anterior, fueron los Estados de Tlaxcala, Michoacán, Coahuila, Colima, Guanajuato, Hidalgo, San Luis Potosí, Distrito Federal (ahora Ciudad de México), Oaxaca, Querétaro y Morelos los que crearían de súbito en los últimos años lo que denominaríamos la segunda generación de leyes archivísticas, que quedarían insertas en el marco de las actuales políticas públicas referidas a la rendición de cuentas, la transparencia y el acceso a la información. Así pues, el objetivo de esta investigación es hacer un recorrido por estas leyes con el fin de observar su impacto en el ámbito de los archivos de este país.
Kemampuan Sintesis Siswa SMP Berdasarkan Self-Esteem Pada Materi Bangun Ruang Sisi Datar
Authors: Viamita Salma , Ramlah Ramlah , Sutirna Sutirna 
Published: August 2021

Tujuan penelitian ini yaitu untuk mendeskripsikan kemampuan sintesis oleh siswa SMP berdasarkan self-esteem pada materi Bangun Ruang Sisi Datar. Penelitian ini menggunakan metode kualitatif deskriptif dengan subjek penelitian diambil sebanyak 3 siswa masing-masing dengan kategori rendah, sedang, dan tinggi dari hasil analisis angket self-esteem yang selanjutnya akan dideskripsikan. Seluruh instrumen yang digunakan sebelum diberikan melalui proses analisis validasi, reliabilitas, daya pembeda dan indeks kesukaran. Seluruh instrumen yang digunakan sebelum diberikan melalui proses analisis validasi, reliabilitas, daya pembeda dan indeks kesukaran. Hasil tersebut kemudian dapat dianalisis menggunakan tahapan reduksi menyajikan, dan mengambil kesimpulan. Hasil penelitian ini menunjukkan bahwa siswa dengan kategori self-esteem tinggi pada kemampuan sintesisnya, yaitu mampu merumuskan masalah, merencanakan masalah dan memproduksikan masalah dengan baik dan benar. Siswa dengan kategori self-esteem sedang pada kemampuan sintesisnya, yaitu hanya mampu merumuskan dan merencanakan masalah, sedangkan pada tahap memproduksi masalah secara matematis siswa belum dapat menguasainya. Siswa dengan kategori self-esteem rendah pada kemampuan sintesinya yaitu mampu merencanakan masalah dengan baik, namun tidak dapat merumuskan dan memproduksikan masalah.