bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized repetitive transcranial magnetic stimulation for primary progressive aphasia
Authors: Pytel Vanesa , Cabrera-Martín María Nieves , Delgado-Álvarez Alfonso , Ayala José Luis , Balugo Paloma , Delgado-Alonso Cristina , Yus Miguel , Carreras María Teresa , Carreras José Luis , Matías-Guiu Jorge , Matias-Guiu JA 
Published: May 2021

Abstract
BackgroundPrimary progressive aphasia (PPA) is a neurodegenerative syndrome for which no effective treatment is available. We aimed to assess the effect of repetitive transcranial magnetic stimulation (rTMS), using personalized targeting.MethodsWe conducted a randomized, double-blind, pilot study of patients with PPA receiving rTMS, with a subgroup of patients receiving active- versus control-site rTMS in a cross-over design. The primary outcome was changes in spontaneous speech (word count). Secondary outcomes included changes in other language tasks, global cognition, global impression of change, neuropsychiatric symptoms, and brain metabolism using FDG-PET.ResultsTwenty patients with PPA were enrolled (14 with nonfluent and 6 with semantic variant PPA). Compared to the control group, the group receiving active-site rTMS showed improvements in spontaneous speech, other language tasks, patient and caregiver global impression of change, apathy, and depression. This group also showed improvement or stabilization of results obtained in the baseline examination. Increased metabolism was observed in several brain regions after the therapy, particularly in the left frontal and parieto-temporal lobes and in the precuneus and posterior cingulate bilaterally.ConclusionsWe found an improvement in language, patient and caregiver perception of change, apathy, and depression using high frequency rTMS. The increase of regional brain metabolism suggests enhancement of synaptic activity with the treatment.Trial registrationNCT03580954 (clinicaltrials.gov). Registered 10 July 2018 (retrospectively registered).URL of the trial registry recordhttps://clinicaltrials.gov/ct2/show/NCT03580954
Bayesian Networks and Causal Inference for the Interpretation of Patients' Symptom Experience
Authors: Papachristou Nikolaos , Barnaghi Payam , Allison Sarah J. , Kober Kord M. , Miaskowski Christine 
Published: May 2021

Abstract
Given that oncology patients experience an average of 14 co-occurring symptoms, the identification of sentinel or core symptoms is a critical need for effective symptom management. However, this task is an extremely challenging one. To address this need, we used Bayesian Network Analysis (BNA) approaches on a comprehensive dataset of 38 distinct and co-occurring cancer symptoms from a sample of 1328 cancer patients receiving chemotherapy. We evaluate three classes of algorithms (constrained-based, score-based, hybrid algorithms) on their structural stability and performance with different sample sizes and demographic characteristics (gender and age). We demonstrate their potential clinical use for casual discovery and inference. The hybrid algorithm identified more dense network structures that were clinically relevant, not only for the entire sample but for our case studies of gender and age. Our work demonstrates how to process a comprehensive set of symptom experience data for interactions and provides valuable information on the use of BNA in clinical practice when different algorithms, sample sizes and comparative sub-groups are evaluated.
Heterogeneous Catalytic Oxidation of 5-hydroxymethylfurfural (5-HMF) To 2,5-Diformoylfuran (DFF) Using Fe3O4@C Catalyst
Authors: Ranganath Kalluri V.S , Jaiswal Rama 
Published: May 2021

Abstract
The selective oxidation of 5-hydroxymethyl furfural (HMF) to 2,5-diformylfuran (DFF) is one of the rapidly growing research area due to having its own importance in the fuel technology. We report a new heterogeneous catalyst for the oxidation of HMF to DFF in aqeous medium using a carbon soot deposited on magnetite (Fe3O4@C). Further, the potentiality of our catalyst has also been realized in direct production of DFF from biomass (using either fructose or glucose) with high conversions via two consecutive steps.
Comparison of 10 emerging SARS-CoV-2 Variants: infectivity, animal tropism, and antibody neutralization
Authors: Zhang Li , Cui Zhimin , Li Qianqian , Yu Yuanling , Wu Jiajing , Nie Jianhui , Ding Ruxia , Wang Haixin , Zhang Yue , Liu Shuo , Chen Zhihai , He Yaqing , Xu Wenbo , Huang Weijin , Wang Youchun 
Published: May 2021

Abstract
Ten emerging SARS-CoV-2 variants—B.1.1.298, B.1.1.7, B.1.351, P.1, P.2, B.1.429, B.1.525, B.1.526-1, B.1.526-2, B.1.1.318—and seven corresponding single amino acid mutations in the receptor-binding domain were examined using SARS-CoV-2 pseudovirus. The results indicate that the current SARS-CoV-2 variants do not increase infectivity among humans. The K417N/T, N501Y, or E484K-carrying variants exhibited increased abilities to infect to mouse ACE2-overexpressing cells. The activities of Furin, TMPRSS2, and cathepsin L were increased against most of the variants. RBD amino acid mutations comprising K417T/N, L452R, Y453F, S477N, E484K, and N501Y caused significant immune escape from 11 of 13 monoclonal antibodies. However, the resistance to neutralization by convalescent serum or vaccines was mainly caused by the E484K mutation, while the neutralization of E484K-carrying variants was decreased by 1.1–6.2-fold. The convalescent serum from B.1.1.7- and B.1.351-infected patients neutralized the variants themselves better than other SARS-CoV-2 variants.
Continuing use of aspirin in total knee arthroplasty: safe or not?
Authors: Li Zeng , Xiang Shuai , Du Yan , Bian Yanyan , Feng Bin , Weng Xisheng 
Published: May 2021

Abstract
Background: There are a growing number of patients who take aspirin routinely before TKA to prevent vascular events. However, it may increase the risk of bleeding and wound complications. It remains controversial regarding the safety of continuing use of aspirin during the perioperative period of TKA. Methods: The present study retrospectively selected TKA cases from the Joint Arthroplasty Database at the Peking Union Medical College Hospital from January 2014 to December 2019. The comparisons between the aspirin group and non-aspirin group on the aspects of bleeding parameters (blood loss, transfusion rate, drainage volume, hemoglobin and hematocrit change) and complications (cardiac events, venous thromboembolism events, cerebrovascular events and wound events) were performed. Results: A total of 560 patients with unilateral TKA and 285 patients with bilateral TKA were extracted. Among those, 280 patients used aspirin preoperatively. No differences were found in demographic and surgical characteristics between the aspirin and non-aspirin group except for the proportion of coronary artery diseases (p<0.05). For the outcomes, there were no significant higher blood loss in the surgery and transfusion rate during or after the surgery in the aspirin group, while the drainage in the aspirin group was higher than control group, especially for bilateral TKAs (p=0.043). And the hemoglobin and hematocrit in POD5 in aspirin group were significant lower in both unilateral and bilateral TKAs. For complications, though there were lower vascular related complication rate in aspirin group after unilateral TKAs (p=0.040), the wound event rate in aspirin group were higher than the control group (p=0.049). Conclusion: Continuing use of aspirin could prevent vascular related complications during the perioperative period of TKA. However, it might also increase the risk of bleeding and wound complications which we should pay attention to.
The Effect of Serum Protein on Enterococcus Faecalis Adhesion to Three types of Root Sealers and Gutta-Percha
Authors: Lin Xinwei , Chi Danlu , Gong Qimei , Tong Zhongchun 
Published: May 2021

Abstract
The aim of this study was to evaluate the effect of serum protein on Enterococcus faecalis adhesion and survival on the surface of Apexit Plus (AP), AH-Plus (AH), a tricalcium silicate–containing sealer (Iroot SP) and gutta-percha (GP). AP, AH or Iroot SP was evenly coated on GP. After root sealers setting, the amount of E. faecalis adhering to the sealers was evaluated in fetal bovine serum (FBS) or TSBG medium by viable cell plate counts. The morphology of the sealers coated on GP and 7-day-old E. faecalis biofilm was observed by scanning electron microscopy (SEM). Furthermore, the ratios of viable and dead cells in biofilm were calculated by a Carl Zeiss confocal laser scanning microscope (CLSM) and ZEN software. In 1 and 7 days of assays, the amount of E. faecalis adhering to the surface of sealers or GP in FBS was significantly less than in TSBG (P < .05). FBS more significantly reduced the bacterial amount on the SP and GP than on the AP and AH. E. faecalis biofilm on the AP and SP were more typical in the TSBG than in the FBS. The ratio of viable cell in the E. faecalis biofilm was the lowest on the SP by CLSM. It can be stated that Apexit Plus, AH-Plus and Iroot SP sealers may provide the substrate for E. faecalis adhesion, and the serum proteins significantly influenced bacterial adhesion to the surface of Apexit Plus, AH-Plus, Iroot SP and gutta-percha.
Macrophages in tumor-associated adipose microenvironment accelerate tumor progression
Authors: Li Bei , Wu Qi , Yang Qian , Li Zhiyu , Li Juanjuan , Wu Juan , Zhu Shan , Wang Lijun , Liao Shichong , Sun Si , Xu Zhiliang , Sun Shengrong 
Published: May 2021

Abstract
Background: Macrophages particularly contribute to the progression of obesity-related tumor. However, the mechanisms that the tumor-adipocyte crosstalk may enable the properties and plasticity of macrophages remain still unclear.Methods: Survival probabilities for recurrence-free survival (RFS) were estimated by the Kaplan–Meier method based on immunohistochemistry and immunofluorescence images. 3T3-L1 cells were co-cultivated with 4T1 and MDA-MB-231 cells. Then the co-cultivated media were used to treat THP-1/RAW264.7 cells. The markers of macrophages were detected by immunofluorescence and Western blot. Transwell migration assay, was conducted to determine the migration capability of macrophages. RT-PCR and ELISA were used to detect the expression and secretion level of chemokines, respectively. Immunofluorescence imaging and Western blot were used to investigate the role of SOCS6/STAT3 signaling pathway in the polarization of macrophages. microRNA mimic and inhibitor, and xenograft models were used to explore the role of miR-155 in the polarization of macrophages.Results: We demonstrate that CD163-positive macrophages aggregated to surround adipocytes in breast cancer tissues, which was associated with tumor relapse. In tumor-adipocyte microenvironment, CD163-positive macrophages are recruited and polarized via the elevated expression of CCL2 and CCL5. Consistently, the eliminated macrophages partially inhibited adipocytes-induced tumor proliferation. Likewise, inhibiting chemokines and their receptors or suppressing the phosphorylation of STAT3 significantly decreased tumor burden in vivo. Finally, the source of CCL2 and CCL5 mainly derived from adipocytes. In coculture of tumor cells and adipocytes, the level of exosomal miRNA-155 was high, then it promoted the generation and release of CCL2 and CCL5 from adipocytes through targeting SOCS6/STAT3 pathway. Inhibition of exosomal miRNA-155 in tumor cells reduced the CCL2 and CCL5 levels in tumor-adipocytes coculture, and further retarded tumor growth.Conclusion: These results suggest a novel target of tumor-adipocyte-macrophage interconnect that could facilitate obesity-induced tumor progression.
Hydration-driven stabilization and volume collapse of grain boundaries in Mg2SiO4 forsterite predicted by first-principles simulations
Authors: Ghosh Dipta B. , Karki Bijaya B. , Wang Jianwei 
Published: May 2021

Abstract
Grain boundaries in mantle minerals are of critical importance to geophysical and geochemical processes of the Earth’s interior. One of the fundamental issues is to understand how the water (H2O) component influences the properties of grain boundaries in silicate materials. Here, we report the results of the structure and stability of several tilt grain boundaries in Mg2SiO4 forsterite over the pressure range 0 to 15 GPa using density functional theory-based first-principles simulations. The results suggest greater energetic stability and hydration-driven volume collapse (negative excess volume) at zero pressure for the majority of hydrous grain boundaries relative to the anhydrous (dry) ones. All the hydrous grain boundaries become increasingly favorable at elevated pressures as the calculated hydration enthalpy systematically decreases with increasing pressure. The hydrous components at the interfacial regions are predominantly in the hydroxyl form and, to a lesser extent, in the molecular H2O form. Their calculated ratio ranges from 1.6 to 8.7 among the different grain boundary configurations. Our structural analysis also reveals that the hydroxyls are bound to either both Mg and Si or to Mg only. In comparison, the molecular species are bound only to Mg sites. Besides direct oxygen-hydrogen bonding, intermolecular hydrogen bonding becomes important with compression. On the basis of our results, we suggest that local atomic rearrangements caused by dissociative adsorption of water facilitate efficient compaction of the boundary interfaces, which, in turn, results in greater relative stability of hydrous grain boundaries. This means that water prefers to be incorporated within the grain boundaries over the bulk of silicate materials.
A high-pressure, clinopyroxene-structured polymorph of albite in highly shocked terrestrial and meteoritic rocks
Authors: Ma Chi , Tschauner Oliver , Kong Mihye , Beckett John R. , Greenberg Eran , Prakapenka Vitali B. , Lee Yongjae 
Published: May 2021

Abstract
Clinopyroxenes with excess Si have been described in run products from high-pressure experiments and inferred to have existed in nature from retrograde transformation phases. Here, we present the discovery of albitic jadeite, (Na,Ca,☐1/4)(Al,Si)Si2O6—the first natural, sodic clinopyroxene with excess Si occupying the octahedral cation site, M1, and a corresponding ¼ vacancy on the M2-site in the Ries impact structure and in a suite of L6 ordinary chondrites, EET 13014, EET 13052, NWA 1662, and TIL 08001. Garnet compositions in these samples indicate shock pressures of 18–22 GPa. Based on our survey, albitic jadeite is likely to be rather common in terrestrial and meteoritic shock-metamorphic environments. Shock-generated jadeite should be reexamined with respect to excess Si.
Sustainability of polymer composites and its critical role in revolutionising wind power for green future
Authors: P. Subadra Sharath , Griskevicius Paulius 
Published: May 2021

Fibre reinforced polymer composites are gaining wide acceptability in different sectors due their high specific mechanical properties. They have effectively replaced conventional material like metals in many applications thus imparting lighter weight with higher efficiency. Wind energy sector has grown tremendously over the last decade and as per “The Global Wind Turbine Market-Forecasts from 2020 to 2025”, global wind turbine market was valued at US$ 90.144 billion in 2019 and is expected to grow at a CAGR of 5.34 % to reach an estimated market size of US$123.154 billion by 2025. Wind turbine blades are fabricated using fibre reinforced composites with ideally a balsa or foam core. The composites used in this case are essentially glass reinforced in epoxy resins, and these highly engineered materials are difficult to recycle as epoxy is a thermoset resin and are not re-mouldable. This poses an environmental problem and a loss in terms of recoverable capital. Thermoplastics as against thermosets could be an alternative resin material for the blades but this has been less explored by the wind sector. The use of thermoplastic could impart cost reductions due to shorter manufacturing cycle times, recovery of raw materials and reduced tooling adjustments in terms of heating. Recovery of composite constituent parts can provide economic benefits because those constituent parts have high embedded energy. In the context of this dilemma of recyclability of wind turbine blades, this review paper intent to explore the current research and future prospect of recycling wind turbine blade materials.
A hospitalidade de Pelotas/RS pela visão de quem não enxerga e aos passos de quem não caminha
Authors: Moraes Rodrigues Igor , Marroni Minasi Sarah , Islabão Lopes Alice , Souza da Silva Luziara 
Published: May 2021

O objetivo proposto desta pesquisa é analisar a hospitalidade da cidade de Pelotas/RS na percepção das pessoas com deficiência visual e física (cadeirantes). Metodologicamente, esta pesquisa caracteriza-se por ser de natureza exploratória e descritiva, realizada por meio de pesquisa bibliográfica com abordagem qualitativa em que foram aplicados questionários com os sujeitos da pesquisa por e-mails e redes sociais Facebook e Whatsapp. Como principais resultados encontrados, identificou-se que o entendimento sobre hospitalidade de todos os sujeitos está relacionado ao bem receber-acolher. Para as pessoas com deficiência visual a questão do respeito com o visitante prevalece enquanto os sujeitos cadeirantes acrescentam a relação com a acessibilidade. No que tange à concepção de hospitalidade urbana e cidade hospitaleira, apesar das dimensões em comum, as falas das pessoas com deficiência visual estão mais relacionadas à identificação e envolvimento ativo do ser humano na cidade, enquanto as pessoas cadeirantes trazem à tona dimensões de acessibilidade física. Já no que diz respeito a Pelotas ser uma cidade hospitaleira, os sujeitos cadeirantes divergem sobre esta concepção apontando a (falta de) acessibilidade física como principal motivo enquanto todos os sujeitos com deficiência visual consideram Pelotas hospitaleira. Com os resultados desta pesquisa foram sistematizadas dimensões da cidade hospitaleira para pessoas com deficiências além de fomentar reflexões sobre hospitalidade e pessoas com distintos tipos de deficiência.
Palavras-chave: Turismo. Hospitalidade Urbana. Deficiência Visual. Cadeirantes. Pelotas/RS.
Personalidade da marca de destinos, fontes de informações e sua relação com o critério de escolha da chapada das mesas por parte dos turistas
Authors: Costa Junior Lindemberg , Christynne De Souza Sampaio Evellyn 
Published: May 2021

Este estudo tem como objetivo identificar o critério de escolha de turistas ao decidir pela Chapada das Mesas, bem como perceber a relação entre o critério de escolha dos turistas e a personalidade da marca de destinos; verificar os traços que constituem a personalidade da marca de destinos na visão de turistas; e identificar o grau de relevância de diferentes fontes de informações utilizadas por turistas na busca por um destino turístico. A Chapada das Mesas está localizada no Estado do Maranhão, havendo a cidade de Carolina como base para explorar as belezas da região. Adotou-se metodologia quantitativa, com caráter descritivo e corte transversal. Neste contexto, optou-se pela coleta primária de dados utilizando o formulário eletrônico Google Forms. Os resultados sugerem que a Chapada das Mesas é um local excitante, muito por conta da beleza do local. Para buscar maiores informações sobre o local de destino, os turistas procuram a opinião de amigos e familiares e também de pessoas confiáveis que já visitaram o local. Revela-se ainda que a internet é um importante canal de informação, pois pode-se ver as fotos e comentários de turistas com experiência previa do local.
Palavras-chave: Marketing Turístico. Personalidade da Marca. Consumidor de Turismo.
PENTINGNYA TES KEMAHIRAN BERBAHASA INDONESIA BAGI PEMELAJAR BIPA BERTUJUAN AKADEMIK
Authors: Kusmiatun, M.Hum. Ari 
Published: May 2021

Penelitian ini bertujuan untuk mendeskripsikan kebutuhan pemelajar asing dalam program BIPA akademik terhadap tes kemahiran berbahasa Indonesia akademik. Penelitian ini merupakan tahap awal dari penelitian pegembangan tes kemahiran berbahasa Indonesia yang diperuntukkan bagi pemelajar BIPA bertujuan akademik. Jenis penelitian dalam tahap awal atau studi pendahuluan ini adalah penelitian kualitatif. Penelitian ini mendeskripsikan beberapa hal terkait kebutuhan tes kemahiran bagi pemelajar asing bertujuan akademik. Pengumpulan data dilakukan dengan menggunakan teknik observasi, dokumentasi, angket, dan wawancara. Subjek penelitiannya adalah pemelajar asing, dosen pengajar yang di kelasnya terdapat mahasiswa asing, dan pengelola program BIPA bertujuan akademik. Teknik analisis data yang digunakan adalah kualitatif. Keabsahan data dalam penelitian ini menggunakan trianggulasi data, berupa tianggulasi sumber dan metode. Hasil penelitian menunjukkan bahwa kebutuhan tes kemahiran berbahasa Indonesia diperlukan oleh para pemelajar asing yang bertujuan akademik. Dengan tes ini, kemampuan berbahasa Indonesia mereka dapat terdeteksi dan disikapi sehingga mereka dapat menjalani perkuliahan dengan baik dan lancar.Kata Kunci: tes kemahiran berbahasa Indonesia, pemelajar asing, bertujuan akademik
PENINGKATAN KOMPETENSI TATA BAHASA PRANCIS MAHASISWA JURUSAN PENDIDIKAN BAHASA PRANCIS FBS UNY DENGAN MODEL PEMBELAJARAN INQUIRY
Authors: Wilujeng Nuning Catur Sri , Sumiyati Siti , T. A. Anggraini Dora , Dwiyuliani Titis 
Published: May 2021

(Title: Improving French Grammar Competence of The Students at French Departement, Faculty of Languages and The Arts, Yogyakarta State Uninersity Through The Inquiry Model). This research aimed to improve the students’ French grammar competence through the Inquiry model with seven steps, ie : developing a question, generating a hypothesis, developing an experimental desain, collecting and recording data, analizing data, reaching conclusions, forming and extending generalizations, communicating results. This research was a class room action reseach study conducted in two cycles from the 2th to 27th May 2016. The research subjects were 21 students atten­ding in Grammaire 4 in classes E and J at the French Departement, Faculty of Languages and the Arts, Yogyakarta State University. The data were collected through observations, field notes, and achievement test. They were analized using qualicative and quantitative descriptive techniques. The results of the study showed that the application of the inquiry model was capable of improving the students’s French grammar learning, both in the process and the product. The success in the process was indicated by student’s activeness in the learning activities for the Grammaire 4 through the inquiry model, and the average attainment in the first cycle was 70.47% and 77.1% in second cycle. The success in product was indicated by improvement of the students’French grammar competence, reflected by the improvement of average score of post-test. The difference between the average score of pre-test and post-test scores was significant because the result of the paired sample t-test both in the first cycle and second one was p (0.001) 0.05. Keywords: inquiry model, French grammar, action research
THE EFFECT OF TELEVISION PROGRAM ON CHILDREN’S FOREIGN LANGUAGE ACQUISITION
Authors: Rajulain Muhammad 
Published: May 2021

(Title: The Effect of Television Program on Children’s Foreign Language Acquisition). Since it was first discovered in the 1920s, television has become an integral part of modern human life. The influence of television programs or programs on children's foreign language acquisition has become an interesting research subject to study. This study aims to determine the effect of television programs on the acquisition of foreign languages in a subject aged two years and three months using a qualitative method where the researcher also acts as an observer. The data obtained is recorded in the form of a diary, and interviews are conducted with parents and the people closest to the subject to obtain accurate data. The results of the study showed that the television programs being watched did not have a significant effect on the acquisition of foreign languages on the subjects studied. Keywords: Television programs, foreign language acquisition, children