bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasal high-frequency oscillatory ventilation versus nasal continuous positive airway pressure as primary respiratory support strategies for respiratory distress syndrome in preterm infants: a systematic review and meta-analysis
Authors: Jie Li , Long Chen , Shi Yuan 
Published: March 2021

Abstract
Nasal high-frequency oscillatory ventilation (NHFOV) has been described to be an advanced version of nasal continuous positive airway pressure (NCPAP). However, its beneficial effects among different studies were inconsistent. The aim of the present study was to assess the effects between NHFOV and NCPAP as the primary respiratory supporting strategies on the intubation rate in preterm infants with respiratory distress syndrome(RDS). Medline, the Cochrane library, the Cochrane Controlled Trials Register, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang data Information Site were searched from inception to Jan 1, 2021(Prospero2019 CRD42019129316, date of registration:Apr-23,2019). Pooled data from clinically randomized controlled trials(RCTs) comparing NHFOV with NCPAP as the primary respiratory supporting strategies in preterm infants with RDS were performed using the fixed-effects models whenever no heterogeneity was shown. The primary outcome was intubation rate. Four randomized controlled trials involving 570 participants were included. Comparing with NCPAP, NHFOV resulted in less intubation rate(relative risk(RR):0.47; 95% confidence interval(CI):0.31–0.70, P = 0.0002), and heterogeneity was not found among the trials in the fixed effects model (P = 0.69, I2 = 0%). Similar result also appeared in sensitivity analysis after excluding one study with significant difference(RR:0.49; 95% CI:0.29–0.81, P = 0.006) (P = 0.52, I2 = 0%). Conclusion NHFOV is superior to NCPAP in decreasing the risk of intubation as a primary respiratory supporting strategies in preterm infants suffering from RDS.
Using Uniform Design Methodology of Turning Parameters Study of Nickel Alloy
Authors: Chen Shao Hsien , Hsu Chih-Hung 
Published: March 2021

Abstract
The nickel alloy has good mechanical strength and corrosion resistance at high temperature, it is extensively used in aerospace, biomedical and energy industries, as well as alloy designs of different chemical compositions to achieve different mechanical properties. However, for high mechanical strength, low thermal conductivity and surface hardening property, the nickel alloy has worse cutting tool life and machining efficiency than general materials. Therefore, how to select the optimum machining parameters will influence the workpiece quality, cost and machining time. For the selection of nickel alloy turning parameters, this paper uses uniform design method to design cutting test to reduce the number of experiments. Three independent variable parameters are set up, including cutting speed, feed motion and cutting depth, and four dependent variable parameters are set up, including cutting tool wear, surface roughness, machining time and cutting force. A nickel alloy turning parameter model is built by using regression analysis to further predict the I/O relationship among various combinations of variables. The errors between actual values and prediction values are validated. When the cutting tool wear (VB) is 2.72~6.18%, the surface roughness (Ra) is 4.10~7.72%, the machining time (T) is 3.75~8.82%, and the cutting force (N) is 1.54~7.42%, the errors of various dependent variables are approximately less than 10%, so a high precision estimation model is obtained through a few experiments of uniform design method.
Modification at A-Ring and Cytotoxic Activity of Betulonic Acid and its N-Methylpyperazinyl Amide
Authors: Giniyatullina Gulnara , Petrova Anastasiya , Mustafin Akhat , Zileeva Zulfia , Kuzmina Ulyana , Vakhitova Yulia , Kazakova Oxana 
Published: March 2021

Abstract
Since cancer remains one of the most prevalent diseases today, there is an urgent need for the development of new agents. Triterpenoids may act in multiple pathways displaying antiproliferative, antiangiogenic, anti-inflammatory, and pro-apoptotic activities that place them as promising multifunctional agents in treating cancer. In this paper a series of betulonic acid and its N-methylpyperazinyl amide derivatives, especially holding C2-nicotinoylidene/furfurylidene/fluorobenzylidene fragments, have been synthesized and evaluated for their cytotoxic activity against the NCI-60 cancer cell line panel. N-Methylpiperazinyl amides of betulinic acid 11 and 4-pyridinoylidene-betulinic acid 9 as well as betulonic acid C2-4-pyridinoylidene- 14 or furfurylidene 16 derivatives were found to be the leading compounds with GI50 values of 0.49 μM for leukemia CCRF-CEM, 1.60 μM and 1.36 μM for colon cancer HCT-116 and 1.66 μM for melanoma LOX IMVI cell lines, respectively. The activity displayed for these compounds was higher than for the standard drug doxorubicin against colon cancer HCT-15 and ovarian cancer NCI/ADR-RES cell lines. Cell cycle analysis indicates that compound 11 promotes cytotoxic activity through the apoptosis induction both in conditionally normal (HEK293) and in cancer (A549, MCF-7) cells, whereas compound 14 exhibits both cytostatic and cytotoxic activity, dependently on cell line evaluated. In particular, in HEK293 cells the compound 14 induces mainly apoptotic cell death, while in A549 and MCF-7 cells cytostatic effect is dependent on cell cycle arrest in G2/M phase.Our results suggest that betulinic acid N-methylpyperazinyl amide 11 is the promising compound for the future drug development antitumor studies.
Research on Single-Machine Scheduling With Past-Sequence-Dependent Setup Times and Effects of Deterioration and Learning
Authors: Yu Gan-hua 
Published: March 2021

Abstract
Some result in a recent paper (Wang et al., Int J Adv Manuf Technol, 41:1221–1226, 2009) are incorrect. In this note, we show by a counterexample that the published results are incorrect.
A stochastic predictive model for Class II rocks post peak modulus
Authors: Akinbinu Victor Abioye 
Published: March 2021

Abstract
The post peak modulus of hard brittle Class II rocks are the least studied geo-mechanical properties of rocks. This is because of the difficulty associated with its determination. The Brazilian tensile strength, pre-failure mechanical properties, ultra-sonic pulse velocity and the mineralogical properties of the rocks were determined. The post peak moduli were determined under brittle uniaxial compression process. Predictive equations were developed for the estimation of the post peak modulus using backward multivariate and stochastic analysis of the determined rocks properties. The result of analysis show that the post peak modulus depends on the Poisson’s ratio and the quartz content of rocks. As the values of duo increases the magnitude of the post peak modulus decreases. Therefore, maximum possible magnitude of post peak modulus will be for mafic rocks with zero quartz content and low value of Poisson’s ratio. While low magnitude of post peak modulus will be for felsic rocks of high proportion of quartz content and high Poisson’s ratio. The backward multivariate analysis has a coefficient of correlation of 0.903 while the correlation coefficient was improved to 0.999 by stochastically modelling the relationship using normal distribution probability function for Poisson’s ratio and exponential distribution function for quartz content. The Mean Absolute Percentage Error (MAPE) was used as performance indicator to assess the predictive performance of the models. The stochastic model shows excellent performance with MAPE of 0.5% while the backward multivariate statistics model has MAPE of 0.9%. Both the backward multivariate and stochastic models are excellent prediction models.
Simulating a High-speed Abrasive Particle Impacting on a Tensile Block Using SPH-FEM
Authors: Liu Yanjie , Zhao Yue , Yoshigoe Kenji , Zhang Shijin , Chen Ming 
Published: March 2021

Abstract
In recent years, more and more researches have been carried out on the erosion mechanism of abrasive particles on target materials in the abrasive waterjet cutting process. However, the effect of material property factors on the target erosion damage is rarely studied systematically. In this work, a 3D smoothed particle hydrodynamics-finite elements model is established for the simulation. The controlled variable method is used to study how each material property factor affects the erosion process of single abrasive particle and to find out the key material property factors of Al6061-T6 and Ti-6Al-4V. The influence of the interaction of the key material property factors on the target erosion damage is further evaluated using the orthogonal test method.
Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation
Authors: Pan Zhenwei , Li Xingda , Zhang Yang , Zhao Yue , Zhou Yang , Han Qilong , Yang Ying , Zhang Lingmin , Shi Ling , Jin Xuexin , Zhang Ruixin , Gao Haiyu , Ma Jiudong , Li Zheng , Xue Gen-Long , Li Desheng , Zhang Zhiren , Lu Yanjie , Yang Baofeng 
Published: March 2021

Abstract
Pathological cardiac hypertrophy is a process characterized by significant disturbance of protein turnover. Cullin-associated and Neddylation-dissociated 1 (CAND1) acts as a coordinator to modulate substrate protein degradation by promoting the formation of specific cullin-based ubiquitin ligase 3 complex in response to the accumulation of specific proteins, which thereby maintains the normal protein homeostasis. However, whether CAND1 titrates the degradation of hypertrophic related proteins and manipulates cardiac hypertrophy remains unknown. In this study, we found that the protein level of CAND1 was increased in the heart tissues from heart failure (HF) patients and TAC mice. CAND1-KO+/- aggravated TAC-induced cardiac hypertrophic phenotypes; in contrast, CAND1-Tg attenuated the maladaptive cardiac remodeling. At the protein level, CAND1 overexpression downregulated, whereas CAND1-KO+/- or knockdown upregulated the expression of calcineurin, a critical pro-hypertrophic protein at both in vivo and in vitro conditions. Mechanistically, CAND1 overexpression favored, whilst CAND1 knockdown blocked the assembly of Cul1/atrogin1/calcineurin complex, an E3 that renders the ubiquitination and degradation of calcineurin. It turned out that calcineurin ubiquitination was suppressed by CAND1 knockdown, but enhanced by CAND1 overexpression. In addition, overexpression of truncated calcineurin that cannot be recognized by atrogin1 abrogated the antihypertrophic effects of CAND1. Notably, CAND1 deficiency-induced hypertrophic phenotypes were partially rescued by knockdown of calcineurin, and application of exogenous CAND1 prevented TAC-induced cardiac hypertrophy and heart failure. In conclusion, CAND1 exerts a protective effect against cardiac hypertrophy and heart failure partially by inducing the degradation of calcineurin. CAND1 represents a novel, promising therapeutic target for cardiac hypertrophy and heart failure.
Keywords: CAND1; heart failure; calcineurin; ubiquitination; cullin1
The Deceleration of Radio/Light Transmission; A Collision Mechanism Dependent Radio Signal Emission, Transmission, and Reception
Authors: Zhang Jing 
Published: March 2021

Abstract
The fast and slow fading of radio signal transmissions or laser beam itself and its spare light confirm the presence of two kinds of collisions --- electron-photon and photon-photon collision. Photon transmissions of radio signals are either in consecutive dense photon groups in slow fading process or widespread group pattern in fast fading form. The photon transmission shapes are irregular and dynamical changes. The radio frequency shift and the wavelength reduction by the calculation demonstrate decelerations of radio/light transmission speeds due to the gradual reduced distance between two consecutive photon groups along the transmission pathway. The simultaneous presence of two radio/light transmission patterns overturns the principle of Special Relativity by Einstein. Photons from radio signals are able to affect electron movements in radio signal receiving process and electrons able to kick photons into space during radio signal emission. The radio signal and light emission and reception are due to the collision between photons and electrons. The local electromagnetic changes between atoms of antenna play the central role. Collision Mechanism explains electron-photon frequency relation of light/radio emission mechanism. Collisions between high- and low-speed photons reduce the speed of high ones. The mathematical equation for the relationship between light/radio transmission speeds before and after photons collisions is established. The equation is confirmed by the calculations of well-known difference of light transmission speeds in different media. The gravities from Earth and Sun play little role during light/radio transmission.
Synthesis, structural and biomedical characterization of hydroxyapatite/borosilicate bioactive glass nanocomposites
Authors: Abulyazied Dalia , Alturki Asma , Youness Rasha , Abomostafa H. 
Published: March 2021

Abstract
In this work, a borosilicate glass sample (5SiO2-45B2O3-20Na2O-25CaO-5Ag2O) was added to nano-sized carbonated hydroxyapatite (CHA) powders with different contents up to 20 wt.% to improve the bioactivity, antibacterial effect, physical and mechanical properties of the resulting nanocomposites. Then, these samples were mixed, milled with a high-energy ball mill, sintered at 700°C and subjected to X-ray diffraction (XRD) technique, Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) to examine their structure, chemical composition and microstructure, respectively. Furthermore, the physical and mechanical properties of the sintered nanocomposites were also measured. Moreover, the in vitro bioactivity of the prepared nanocomposites was examined with XRD and SEM. Additionally, the antibacterial behavior of these samples was tested against E. coli and S. aureus by the disc-diffusion method. The results obtained pointed out that the sample with the highest content of BG possessed the best bioactivity, antibacterial effect, physical and mechanical properties.
miR-29a-5p Alleviates Traumatic Brain Injury (TBI)-Induced Permeability Disruption Via Regulating NLRP3 Pathway
Authors: Zhang Aijun , Lu Youming , Yuan Lei , Zhang Pengqi , Zou Dongdong , Wei Fance , Chen Xin 
Published: March 2021

Abstract
Blood-brain barrier (BBB) dysfunction is presented during traumatic brain injury (TBI) and is dependent upon the activation of the NLRP3/Caspase-1 inflammasome pathway. MicroRNA (miRNA) was proved to inhibit signaling pathway activation by targeting gene expression and we predicated in the database that miR-29a targets to NLRP3. Herein, this study aims to define the regulating role of miR-29a in NLRP3 expression and NLRP3/Caspase-1 inflammasome activation in TBI-induced BBB dysfunction. Our results indicated that miR-29a-5p alleviates TBI-induced the increased permeability of endothelial cell and BBB via suppressing NLRP3 expression and NLRP3/Caspase-1 inflammasome activation, providing a promising strategy for relieving TBI via inhibiting NLRP3/Caspase-1 inflammasome activation.
LncRNA-URHC&nbsp;Functions as a ceRNA to Regulate Danjb9 Expression by Competitively Binding to miR-5007-3p in Hepatocellular Carcinoma
Authors: niu kunwei , Qu Shibin , Zhang Xuan , Dai Jimin , Wang Jianlin , Nie Ye , Zhang Hong , Tao Kaishan , Song Wenjie 
Published: March 2021

Abstract
Background: Hepatocellular carcinoma (HCC) is often diagnosed at a late stage, when the prognosis is poor. The regulation of long non-coding RNAs (lncRNAs) plays a crucial role in HCC. However, the precise regulatory mechanisms of lncRNA signaling in HCC remain largely unknown. We study aim to investigate the underlying mechanisms of lncRNA (upregulated in hepatocellular carcinoma) URHC in HCC. Methods: RT-qPCR, fluorescence in situ hybridization (FISH) staining, EdU, colony formation, and tumor xenografts experiments were used to identify localized and biological effects of URHC on HCC cells in vitro and in vivo. The bioinformatics analysis, Dual-luciferase reporter assay, and rescue experiments revealed the potential mechanism of URHC.Results: URHC silencing may inhibit the HCC cells proliferation in vitro and in vivo. We found that URHC was mainly localized in the cytoplasm. The expression of miR-5007-3p was negatively regulated by URHC. And miR-5007-3p could reverse the effect of URHC in HCC cells. The expression of DNAJB9 was negatively regulated by miR-5007-3p but positively regulated by URHC. These suggesting of lncRNA-URHC positively regulated the level of DNAJB9 by sponging miR-5007-3p.Conclusion: Together, our study elucidated the role of URHC as a miRNA sponge in HCC, and shed new light on lncRNA-directed diagnostics and therapeutics in HCC.
Preparation and Performance Characterization of a new dust suppressant with a cross-linked network structure for use in open-pit coal mines
Authors: Jin Hu , Zhang Yansong , Li Nan , Yang Junjie , Xi Ya , Cai Li , Pan Zhichao 
Published: March 2021

Abstract
In an effort to control dust pollution in open-air environments such as pit coal mines and coal transportation systems, a new dust suppressant with a cross-linked network structure was prepared. Graft copolymerization of soy protein isolate (SPI) and methacrylic acid (MAA), using potassium persulfate (KPS) as the initiator and hexametaphosphoric acid (SHMP) as the cross-linking agent, formed the network structure. The optimal MAA/SPI mass ratio for the dust suppressant was determined through a single factor experiment to be 3:4, with 0.8 and 0.2 g of SHMP and KPS, respectively. The grafting reaction required 30 min at 60 ℃. Scanning electron microscopy, energy-dispersive x-ray spectroscopy, Fourier-transform infrared spectroscopy, and differential scanning calorimetry were used to characterize the structure and application performance of the dust suppressant. The experimental results showed that the graft copolymerization reaction successfully formed the desired cross-linked network, and that when the cross-linked network material was sprayed on coal dust it formed a dense, solidified shell, which effectively resisted wind erosion and served as a dust suppressant. The average reduction of the total suspended particulate matter of an open-air coal pile reached 79.95%, demonstrating effective dust suppression.
Role of heparanase 2 (Hpa2) in gastric cancer
Authors: Liu JingJing , Knani Ibrahim , Gross-Cohen Miriam , Jiaxi Hu , Sumin Wang , Li Tang , Ilan Neta , Yang Shiming , Vlodavsky Israel 
Published: March 2021

Abstract
BackgroundHeparanase is highly implicated in tumor metastasis due to its capacity to cleave heparan sulfate (HS) and, consequently, remodel the extracellular matrix (ECM) underlying epithelial and endothelial cells. In striking contrast, only little attention was given to its close homolog, heparanase 2 (Hpa2), possibly because it lacks HS-degrading activity typical of heparanase. MethodsWe combined clinical, in vivo and in vitro studies to reveal the role of Hpa2 in gastric cancer. ResultsHere, we report that gastric cancer patients exhibiting high levels of Hpa2 survive longer. Similarly, mice administrated with gastric carcinoma cells engineered to over-express Hpa2 produced smaller tumors and survived longer than mice administrated with control cells. This was associated with increased phosphorylation of AMP-activated protein kinase (AMPK), a kinase that is situated at the center of a tumor suppressor network known to attenuate the growth of various types of cancer including gastric cancer. We also found that MG132, an inhibitor of the proteasome that results in proteotoxic stress, prominently enhances Hpa2 expression. Notably, Hpa2 induction by MG132 appeared to be mediated by AMPK, and AMPK was found to induce the expression of Hpa2, thus establishing a loop that feeds itself where Hpa2 enhances AMPK phosphorylation that, in turn, induces Hpa2 expression, leading to attenuation of gastric tumorigenesis. ConclusionsThese results indicate that high levels of Hpa2 in some tumors but not in others are due to stress conditions that tumors often experience due to their high rates of cell proliferating, high metabolic demands, and changes in the tumor microenvironment. This increase in Hpa2 levels by the stressed tumors appears critically important for the patient's outcome.
Feeding the critically ill child in intensive care units: a descriptive qualitative study in two tertiary hospitals in Ghana
Authors: Abukari Alhassan Sibdow , Acheampong Angela Kwartemaa 
Published: March 2021

Abstract
Background: Critically ill children require optimum feeding in the intensive care for speedy recovery. Several factors determine their feeding and the feeding method to adopt to address this phenomenon. The aim of this study was to explore and describe the feeding criteria of critically ill children at the neonatal and paediatric intensive care units.Methods: A descriptive qualitative design was used to conduct the study. Six focus group discussions were conducted, and each group had five members. In addition, twelve one-on-one interviews were conducted in two public tertiary teaching hospitals in Ghana and analyzed by content analysis using MAXQDA Plus version 2020 qualitative software. Participants were selected purposively (N=42).Results: The decision to feed a critically ill child in the ICU was largely determined by the child’s medical condition as well as the experts’ knowledge and skills to feed. It emerged from the data that cup feeding, enteral, parenteral and breastfeeding were the feeding processes employed by the clinicians to feed the critically ill children.Conclusions: Regular in-service training of clinicians on feeding critically ill children, provision of logistics and specialized personnel in the ICU is recommended to reduce possible infant and child mortality resulting from feeding.
The value of a patient global assessment in management of sarcoidosis
Authors: Baughman Robert , Kotzin Jeffrey , Lower Elyse E 
Published: March 2021

Abstract
The patient global assessment (PGA) is a reported outcome instrument used to gauge the patient’s well-being. We performed a prospective study of patients seen at the University of Cincinnati Sarcoidosis Clinic. Two groups were studied: those at first visit during the time period (Initial) and those seen at least one more time by the same physician (Follow-up). A total of 1006, including 677 Initial visits, occurred during the six month period. Patients who initiated or increased their anti-inflammatory therapy had a significantly lower mean PGA score (ANOVA P<0.001, p<0.05 for increased versus all others). There was no significant difference in initial PGA score based on race, sex, or age. The change in PGA was significantly lower for those who increased medication (ANOVA P<0.001, increased different from all others, p<0.05). The PGA was significantly lower for patients who increased anti-inflammatory therapy initially or at follow-up, however there was overlap between groups.