bluuebunny/crossref_metadata_2025_split huggingface dataset:
NILAI NILAI KEARIFAN LOKAL SEBAGAI PEMBENTUK KARAKTER MASYARAKAT
Authors: Mazid Sukron , Prasetyo Danang , Farikah Farikah 
Published: November 2021

Penelitian ini bertujuan untuk mengetahui kandungan nilai-nilai kearifan lokal yang hidup di masyarakat sehingga mampu menjadi pedoman hidup dalam membentuk karakter masyarakat setempat. Tulisan in merupakan penelitian deskriptif kualitatif. Penelitian dilaksanakan di Magelang Raya yang terdiri dari Kota Magelang dan Kabupaten Magelang dari Bulan Mei sampai dengan Bulan Agustus 2020. Subjek penelitian ditentukan dengan cara purposive, yakni tokoh-tokoh yang peham tentang kondisi masyarakat dan lingkungan Magelang. Hasil penelitian ini menemukan adanya nilai-nilai kearifan lokal yang mampu membentuk karakter masyarakat Magelang Raya. Kearifan lokal tersebut terdiri dari: (1) unsur sosial masyarakat dengan adanya pondok atau masyarakat pesantren sehingga memberikan corak masyarakat yang religius dan patuh terhadap pemimpinnya, akademi militer yang mampu memberikan teladan karakter yang tanggung jawab, disiplin, patriotik, semangat kebangsaan; (2) unsur keberadaan situs sejarah Candi Borobudur yang membentuk masyarakat memiliki karakter toleransi untuk tetap menjaga keharmonisan dalam keberagaman; (3) unsur budaya atau kesenian musik Gejog Lesung yang sarat akan pesan moral untuk bersama dalam keberagaman dan berbeda dalam kebersamaan; (4) unsur alam dengan adanya Gunung Tidar yang memiliki banyak prasasti dengan tulisan Aksara Jawa yang mengandung falsafah hidup sarat akan pesan moral untuk membentuk karakter jujur, bertanggung jawab, rendah hati, saling tolong menolong, dan menghindari kekerasan dalam setiap penyelesaian masalah dalam kehidupan.
mHealth Intervention to Improve Treatment Outcomes Among People With HIV Who Use Cocaine: Protocol for a Pilot Randomized Controlled Trial
Authors: Ranjit Yerina S , Krishnan Archana , Ghosh Debarchana , Cravero Claire , Zhou Xin , Altice Frederick L 
Published: November 2021

Background
Antiretroviral therapy is effective in reducing HIV-related morbidity, mortality, and transmission among people with HIV. However, adherence and persistence to antiretroviral therapy are crucial for successful HIV treatment outcomes. People with HIV who use cocaine have poor access to HIV services and lower retention in care.

Objective
The primary goal of this paper is to provide a detailed description of a mobile health intervention. This study is designed to improve medication adherence among people with HIV who use cocaine. A secondary goal is to list the important challenges and adaptations incorporated in the study design.

Methods
This study, titled Project SMART, used a wireless technology–based intervention, including cellular-enabled electronic pillboxes called TowerView Health and smartphones, to provide reminders and feedback on adherence behavior. The intervention design was based on the theoretical frameworks provided by the self-determination theory and the Motivation Technology Model. The 12-week pilot randomized controlled trial with four arms provided three types of feedback: automated feedback, automated+clinician feedback, and automated feedback+social network feedback.

Results
The study was funded by the National Institute of Drug Abuse (R21DA039842) on August 1, 2016. The institutional review board for the study was approved by Yale University on March 21, 2017. Data collection lasted from June 2017 to January 2020. The final enrollment was 71 participants, of whom 57 (80%) completed the study. The data are currently undergoing analysis, and the manuscript is being developed for publication in early 2022.

Conclusions
Implementing complex mobile health interventions for high-risk and marginalized populations with multicomponent interventions poses certain challenges, such as finding companies with adequate technology for clients and financial stability and minimizing the research-related burden for the study population. Conducting feasibility studies is important to recognize these challenges and the opportunity to address these challenges with solutions while keeping the design of a randomized controlled trial as true as possible.

Trial Registration
Clinicaltrials.gov NCT04418076; https://clinicaltrials.gov/ct2/show/NCT04418076

International Registered Report Identifier (IRRID)
DERR1-10.2196/28332
Human-Centered Design of Mobile Health Apps for Older Adults: Systematic Review and Narrative Synthesis
Authors: Nimmanterdwong Zethapong , Boonviriya Suchaya , Tangkijvanich Pisit 
Published: November 2021

Background
The world is aging. The number of older patients is on the rise, and along with it comes the burden of noncommunicable diseases, both clinical and economic. Attempts with mobile health (mHealth) have been made to remedy the situation with promising outcomes. Researchers have adopted human-centered design (HCD) in mHealth creation to ensure those promises become a reality.

Objective
This systematic review aims to explore existing literature on relevant primary research and case studies to (1) illustrate how HCD can be used to create mHealth solutions for older adults and (2) summarize the overall process with recommendations specific to the older population.

Methods
We conducted a systematic review to address the study objectives. IEEE Xplore, Medline via Ovid, PubMed, and Scopus were searched for HCD research of mHealth solutions for older adults. Two independent reviewers then included the papers if they (1) were written in English, (2) included participants equal to or older than 60 years old, (3) were primary research, and (4) reported about mHealth apps and their HCD developments from start to finish. The 2 reviewers continued to assess the included studies’ qualities using the Mixed Methods Appraisal Tool (MMAT). A narrative synthesis was then carried out and completed.

Results
Eight studies passed the eligibility criteria: 5 were mixed methods studies and 3 were case studies. Some studies were about the same mHealth projects with a total of 5 mHealth apps. The included studies differed in HCD goals, target groups, and details of their HCD methodologies. The HCD process was explored through narrative synthesis in 4 steps according to the International Standardization Organization (ISO) standard 9241-210: (1) understand and specify the context of use, (2) specify the user requirements, (3) produce design solutions to meet these requirements, and (4) evaluate the designs against requirements. The overall process and recommendations unique to older adults are summarized logically with structural order and time order based on the Minto pyramid principle and ISO 9241-210.

Conclusions
Findings show that HCD can be used to create mHealth solutions for older adults with positive outcomes. This review has also summarized practical HCD steps and additional suggestions based on existing literature in the subfield. However, evidence-based results are still limited because most included studies lacked details about their sampling methods and did not set objective and quantifiable goals, leading to failure to draw significant conclusions. More studies of HCD application on mHealth for older adults with measurable design goals and rigorous research strategy are warranted.
A Telemedicine-Guided Self-Collection Approach for PCR-Based SARS-CoV-2 Testing: Comparative Study
Authors: Würstle Silvia , Erber Johanna , Hanselmann Michael , Hoffmann Dieter , Werfel Stanislas , Hering Svenja , Weidlich Simon , Schneider Jochen , Franke Ralf , Maier Michael , Henkel Andreas G , Schmid Roland M , Protzer Ulrike , Laxy Michael , Spinner Christoph D 
Published: November 2021

Background
Large-scale, polymerase chain reaction (PCR)-based SARS-CoV-2 testing is expensive, resource intensive, and time consuming. A self-collection approach is a probable alternative; however, its feasibility, cost, and ability to prevent infections need to be evaluated.

Objective
This study aims to compare an innovative self-collection approach with a regular SARS-CoV-2 testing strategy in a large European industrial manufacturing site.

Methods
The feasibility of a telemedicine-guided PCR-based self-collection approach was assessed for 150 employees (intervention group) and compared with a regular SARS-CoV-2 testing approach used for 143 employees (control group). Acceptance, ergonomics, and efficacy were evaluated using a software application. A simulation model was implemented to evaluate the effectiveness. An interactive R shiny app was created to enable customized simulations.

Results
The test results were successfully communicated to and interpreted without uncertainty by 76% (114/150) and 76.9% (110/143) of the participants in the intervention and control groups, respectively (P=.96). The ratings for acceptability, ergonomics, and efficacy among intervention group participants were noninferior when compared to those among control group participants (acceptability: 71.6% vs 37.6%; ergonomics: 88.1% vs 74.5%; efficacy: 86.4% vs 77.5%). The self-collection approach was found to be less time consuming (23 min vs 38 min; P<.001). The simulation model indicated that both testing approaches reduce the risk of infection, and the self-collection approach tends to be slightly less effective owing to its lower sensitivity.

Conclusions
The self-collection approach for SARS-CoV-2 diagnosis was found to be technically feasible and well rated in terms of acceptance, ergonomics, and efficacy. The simulation model facilitates the evaluation of test effectiveness; nonetheless, considering context specificity, appropriate adaptation by companies is required.
PARALLELISM OF DISTRIBUTIONS AND GEODESICS ON F(±a2; ±b2)-STRUCTURE LAGRANGIAN MANIFOLD
Authors: Khan Mohammad Nazrul Islam , Das Lovejoy S. 
Published: November 2021

This paper deals with the Lagrange vertical structure on the vertical space TV (E) endowed with a non null (1,1) tensor field FV satisfying (Fv2-a2)(Fv2+a2)(Fv2 - b2)(Fv2 + b2) = 0. In this paper, the authors have proved that if an almost product structure P on the tangent space of a 2n-dimensional Lagrange manifold E is defined and the F(±a2; ±b2)-structure on the vertical tangent space TV (E) is given, then it is possible to define the similar structure on the horizontal subspace TH(E) and also on T(E). In the next section, we have proved some theorems and have obtained conditions under which the distribution L and M are r-parallel, r¯ anti half parallel when r = r¯ . The last section is devoted to proving theorems on geodesics on the Lagrange manifold
A Novel Drug Delivery of Microspheres
Authors: Walia Smily , Dua J.S. , Prasad D.N. 
Published: November 2021

Microspheres are multiparticulate drug delivery systems that distribute medications at a predetermined rate to a specific region. Microspheres are free-flowing powders manufactured from biodegradable proteins or synthetic polymers, with particle sizes ranging from 1 to 1000 micrometers. Benefits of using microspheres in medication delivery, bone tissue manufacture, and pollutant absorption and desorption by regeneration .The study demonstrates how microsphere parameters are planned and measured. Bioadhesive microspheres, polymeric microspheres, magnetic microspheres, floating microspheres, and radioactive microspheres are only a few examples of complicated microspheres. Cosmetics, oral medication administration, target drug delivery, ocular drug delivery, gene delivery, and other industries covered in the paper could all benefit from microspheres. To ensure best therapeutic effectiveness, the agent must be delivered to target tissue at an optimal amount during the appropriate timeframe, with low toxicity and adverse effects. There are several methods for delivering the therapeutic substance to the target site in a controlled manner. The use of microspheres as medication carriers is one such technique. The value of microspheres as a novel drug delivery carrier to accomplish site-specific drug delivery was discussed in this article.
Keywords: Microspheres, method of preparations, polymer bioadhesion, types of microspheres.
Will Mesenchymal Stem Cell Therapy Be Effective In COVID-19?
Authors: Kalai Srinivas , Senthil M , Sambath Kumar R , Kameshwaran R 
Published: November 2021

Background: The World Health Organization (WHO) reports that the outbreak of the deadly virus had been noted almost in all the countries worldwide. Newly no standard therapies are available to combat the situation and this remains the major challenge for healthcare professionals to provide effective treatment against the life-threatening condition. A potential regenerative medicine method using the infusion of stem cells for the treatment of lung disorders has been reported. This review attempted to explore the immunomodulatory characteristics of Mesenchymal Stem Cells (MSCs) and how these properties make them beneficial for the treatment of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) patients.
Objectives: To study the effect of Mesenchymal Stem Cell therapy in treating COVID-19.
Methodology: A literature search was conducted to identify recent research relating to the review's goal of analyzing the relevance of stem cells in battling SARS-CoV-2.
Results: The MSCs settle in the lungs intravenously to enhance the pulmonary microenvironment, minimize immune system over-activation, and encourage regeneration of damaged lung tissues. Its therapeutic properties like immune response inhibition play a major role in combating viruses. The avoidance of cytokine storm is the most important stage in COVID-19 therapy. Their potent immunomodulatory properties have positive effects in avoiding or attenuating the cytokine storm and assisting in the regeneration of injured lung tissues/other organs.
Conclusion: Intravenous human Umbilical Cord-Mesenchymal Stem Cell therapy (hUC-MSC) transplantation is a safe and effective technique that may be used as a restoration and prioritized therapeutic option for treating severe COVID-19.
Keywords: Covid-19, human Umbilical Cord-Mesenchymal Stem Cell therapy (huc-msc), Immune system.
ANALISIS BISNIS CENDERAMATA DAN JASA PERJALANAN WISATA MENGGUNAKAN BUSINESS MODEL CANVAS (BMC) DAN METODE PIECES
Authors: Singgalen Yerik Afrianto , Sediyono Eko , Sembiring Irwan 
Published: November 2021

The use of information technology in the marketing of souvenirs and travel services based on the e-commerce concept can reach a wider market share via the internet. In the context of Micro, Small, and Medium Enterprises, the dynamics of entrepreneurship are holistic, so they need to be studied contextually. This article aims to analyze the business processes of Souvenirs and Travel Services that are carried out conventionally using the Business Model Canvas to determine the strengths, weaknesses, threats, and opportunities. Then analyze the aspects of Performance, Information, Economic, Control, Efficiency, and Services in Souvenirs and Travel Services businesses. This research uses descriptive qualitative methods. The data collection techniques used were in-depth interviews, observation, and document study. Meanwhile, data processing uses triangulation techniques. This study indicates that the adoption of information technology can support the operations of MSMEs in reducing marketing costs and providing convenience in terms of transactions and communication via digital platforms. Adopt the e-Commerce concept through the WordPress application, especially using the WooCommerce plugin and 3CX Live Chat on the website has made the transaction process and communication easier between sellers and consumers. The convergence between traditional and digital businesses can improve the performance of MSMEs.Pemanfaatan teknologi informasi dalam pemasaran bisnis cenderamata dan jasa perjalanan wisata berdasarkan konsep e-commerce dapat menjangkau pangsa pasar yang lebih luas melalui internet. Dalam konteks Usaha Mikro Kecil Menengah (UMKM), dinamika berwirausaha bersifat holistik sehingga perlu dikaji secara konstekstual. Artikel ini bertujuan menganalisis proses bisnis cenderamata dan jasa perjalanan wisata yang dilakukan secara konvensional menggunakan Business Model Canvas (BMC) untuk mengetahui kelebihan, kelemahan, ancaman dan peluang. Kemudian mengidentifikasi dan menganalisis aspek Performance, Information, Economic, Control, Efficiency, and Services (PIECES) pada usaha cenderamata dan jasa perjalanan wisata yang telah mengadopsi konsep e-commerce. Penelitian ini menggunakan metode kualitatif deskriptif. Hasil penelitian ini menunjukkan bahwa adopsi teknologi informasi dapat mendukung operasional UMKM dalam mereduksi biaya pemasaran serta memberikan kemudahan dalam hal transaksi maupun komunikasi melalui platform digital. Adopsi konsep e-commerce melalui aplikasi WordPress, khususnya penggunaan plugin WooCommerce dan 3CX Live Chat dalam website CV. Xindotour telah memudahkan proses transaksi dan komunikasi antara penjual dan konsumen.
Pengaruh Ekspektasi Pengembalian, Toleransi Risiko, Dan Efikasi Diri Terhadap Minat Investasi Saham
Authors: Frans Frans , Handoyo Sarwo Edy 
Published: November 2021

The purpose of this research is to examine the influence of expected return, risk tolerance, and self-efficacy toward stock investment intention. Sample collection was conducted using the Google Form online questionnaire with a purposive sampling, type of non-probability sampling method, with a total of 100 respondents from the Faculty of Economics and Business, Universitas Tarumanagara, Jakarta. Data processing is done by PLS-SEM method and analyzed with SmartPLS 3.2.8. The results of this study indicate that expected return and risk tolerance have a significant positive effect on stock investment intention. Whereas, self-efficacy does not have a significant effect. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekspektasi pengembalian, toleransi risiko, dan efikasi diri terhadap minat investasi saham. Pengumpulan sampel dilakukan dengan menggunakan kuesioner online Google Form dengan metode non-probability sampling berjenis purposive sampling dengan total 100 responden mahasiswa Fakultas Ekonomi dan Bisnis, Universitas Tarumanagara Jakarta. Pengolahan data dilakukan dengan metode PLS-SEM dan dianalisis dengan SmartPLS 3.2.8. Hasil penelitian ini menunjukan bahwa ekspektasi pengembalian dan toleransi risiko memiliki pengaruh positif signifikan terhadap minat investasi saham. Sedangkan, efikasi diri tidak memiliki pengaruh yang signifikan.
Pengaruh Gaya Kepemimpinan, Disiplin Kerja, Dan Motivasi Kerja Terhadap Kinerja Karyawan PT. LIMAS SURYA MAKMUR
Authors: Agustine Marceline Tania , Edalmen Edalmen 
Published: November 2021

The purpose of this research was to determine the effect of leadership style, work discipline, and work motivation on employee performance at PT. Limas Surya Makmur. The population in this study were all 59 employees of PT. Limas Surya Makmur. The sample research method uses a non-probability design, sampling techniques saturated with quantitative research and using questionnaires to collect data. The results showed that leadership style and work discipline gave a positive and significant influence on the performance of employees of PT Limas Surya Makmur and work motivation gave a positive but not significant effect on the performance of employees at PT. Limas Surya Makmur. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh gaya kepemimpinan, disiplin kerja, dan motivasi kerja terhadap kinerja karyawan di PT. Limas Surya Makmur. Populasi dalam penelitian ini adalah seluruh karyawan PT. Limas Surya Makmur yang berjumlah 59 orang. Metode penelitian sampel menggunakan desain non probabilitas yaitu teknik sampling jenuh dengan penelitian kuantitatif dan menggunakan kuesioner untuk mengumpulkan data. Hasil penelitian menunjukkan bahwa gaya kepemimpinan dan disiplin kerja memberi pengaruh positif dan signifikan terhadap kinerja karyawan PT Limas Surya Makmur serta motivasi kerja memberi pengaruh positif namun tidak signifikan terhadap kinerja karyawan di PT. Limas Surya Makmur.
Implications of Urban Law on Urban Renewal Projects in the Historical Center of Lima
Authors: Isidro Ferrer Liz 
Published: November 2021

The Historic Center of Lima currently shows signs of urban deterioration as a result of the processes of exclusion and spatial segregation that have characterized the intense urban growth of the city of Lima. In the face of this urban deterioration, urban renewal processes are an instrument of transformation that acts as surgery for the recovery and reintegration of deteriorated central areas into the functioning of the current city. As a general, urban law regulates urban problems resulting from the transformation of urban lands, including the deterioration of central areas. In particular, actions in traditional central areas have regulations for the protection of cultural heritage. Therefore, the execution of the urban renewal process requires different regulatory instruments to plan and manage the renewal process, which defines its scope.
In this sense, the present research has been proposed to address the implementation process of three urban renewal projects in collective housing located in the Historic Center of Lima; "Casa de las Columnas", the "Conjunto de Vivienda La Muralla" and the "Proyecto Piloto Martinete", to identify the effectiveness of the scope of the legal framework of urban renewal, as well as the procedures of intervention in historic centers and monumental areas. Focus on the analysis of the public administration's management, execution, and control activities in the land transformation process of deteriorated traditional urban areas. The article consists of the following parts. First, some conceptual considerations on urban renewal and its relationship with urban law are presented. The next section provides an overview of the state of the regulatory framework for urban renewal in Peru, which is key to contextualize the analysis of the case studies. The third part presents the study methodology and the limitations of the study. The fourth part presents the case studies and develops the scope of the legal framework of urban renewal in the case studies. Finally, some final reflections and conclusions are presented that establish the important elements that should be considered in the legal framework of urban renewal.
City Hall v. The World – Seeking New Paradigms for Foreign Missions Municipal Taxation
Authors: Apter Itai 
Published: November 2021

Studies of international law and cities have been attracting the attention of scholars and policy makers alike in attempts to understand the complex nature of the central versus municipal government relationship in respect of international legally binding frameworks. One example of such an intricate relationship is the implementation of treaty and customary international law in respect of taxation of foreign missions. Alongside the importance of the issue to the day to day life and functioning of international relations it can present challenges to policy and decision makers of various layers of government.
The paper offers an analysis of the foreign missions’ taxation case study in the context of the theme of law and international law and the city. Discussion focuses on the basics of the applicable regimes and their history and rationales, as well as on the dilemmas associated with more contemporary forms of municipal taxes. Aiming for developing means to address the challenges presented, a new paradigm is offered, focusing on new methodologies to bring cities to the table to discuss together with state actors how to optimize the balance between the need to facilitate bilateral cross-border relationships and the needs of cities and residents.
In the final stage of the debate, the paper offers potential lessons which can learned from the analysis of the foreign missions’ taxation case study for engagement of cities and states in international policy and law making for central and municipal government. The modality offered can hopefully facilitate the development of processes conducive to enhanced cooperation between cities and states in making and implementing better and more balanced international law.