bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local characteristics of the standing genetic diversity of European beech with high within-region differentiation at the eastern part of the range
Authors: Höhn M. , Major E. , Avdagić A. , Bielak K. , Bosela M. , Coll L. , Dinca L. , Giammarchi F. , Ibrahimspahić A. , Mataruga M. , Pach M. , Uhl E. , Zlatanov T. , Cseke K. , Kovács Zs. , Palla B. , Ladányi M. , Heinze B. 
Published: April 2021

Developing “climate smart forestry” (CSF) indicators in mountain forest regions requires collection and evaluation of local data and their attributes. Genetic resources are listed among the core indicators for forest biological diversity. This study is a report on the evaluation of the standing genetic diversity within and across 12 pure beech stands (Fagus sylvatica L.) established within the CLIMO (CLImate Smart Forestry in MOuntain Regions) project, using nuclear microsatellite markers. The sampling sites were set along the species’ distribution range, including the Balkan region and extending towards the Iberian Peninsula. Cores or leaves from 20 to 23 old, mature trees per plot were sampled for DNA analysis. Genetic diversity indices were high across the range (HE = 0.74−0.81) with the highest in the Bosnian Mountains. Genetic divergence increased significantly with the geographical distance (Mantel test: r = 0.81, p < 0.001). Most of the stands exhibited an excess of heterozygotes, with the highest value at the Hungarian site (HO/HE = 1.177), where beech persists close to the eastern xeric limit of the species’ distribution. STRUCTURE revealed within-region differentiation in the Balkan Peninsula, where the Bulgarian stand was the most outstanding. The genetic parameters of each stand could be assessed as a resource for CSF indicators interpreted especially at the local level.
Hawking evaporation of Einstein–Gauss–Bonnet AdS black holes in $$D\geqslant 4$$ dimensions
Authors: Wu Chen-Hao , Hu Ya-Peng , Xu Hao 
Published: April 2021

AbstractEinstein–Gauss–Bonnet theory is a string-generated gravity theory when approaching the low energy limit. By introducing the higher order curvature terms, this theory is supposed to help to solve the black hole singularity problem. In this work, we investigate the evaporation of the static spherically symmetric neutral AdS black holes in Einstein–Gauss–Bonnet gravity in various spacetime dimensions with both positive and negative coupling constant $$\alpha $$
α
. By summarizing the asymptotic behavior of the evaporation process, we find the lifetime of the black holes is dimensional dependent. For $$\alpha >0$$

α
>
0

, in $$D\geqslant 6$$

D
⩾
6

cases, the black holes will be completely evaporated in a finite time, which resembles the Schwarzschild-AdS case in Einstein gravity. While in $$D=4,5$$

D
=
4
,
5

cases, the black hole lifetime is always infinite, which means the black hole becomes a remnant in the late time. Remarkably, the cases of $$\alpha >0, D=4,5$$

α
>
0
,
D
=
4
,
5

will solve the terminal temperature divergent problem of the Schwarzschild-AdS case. For $$\alpha <0$$

α
<
0

, in all dimensions, the black hole will always spend a finite time to a minimal mass corresponding to the smallest horizon radius $$r_{min}=\sqrt{2|\alpha |}$$

r

min

=

2
|
α
|

which coincide with an additional singularity. This implies that there may exist constraint conditions to the choice of coupling constant.
Scoresbysund Composite Tectono-Sedimentary Element, East Greenland Rifted Margin, Denmark Strait
Authors: Fyhn Michael B. W. 
Published: April 2021

Abstract
The little explored central East Greenland margin contains thick sedimentary accumulations confined within the Scoresbysund Basin. The geological evolution of the area distinguishes it from other parts of East Greenland. Even so, resemblances with the prospective basins onshore and offshore further north probably exist, and the margin may hold real petroleum potential. The Scoresbysund Composite Tectono-Sedimentary Element (CTSE) delineates the oldest part of the Scoresbysund Basin. It formed through multiple phases of rifting, volcanism, uplift and thermal subsidence between Devonian and Miocene times. The development of the CTSE concluded with the latest Oligocene or early Miocene continental break-up of the Jan Mayen microcontinent and East Greenland. The Scoresbysund CTSE contains approximately 4 km of Eocene–lower Miocene fan-delta deposits that accumulated during downfaulting along the East Greenland Escarpment and which further seawards intercalate with basalts. The fan-delta deposits rest on Paleocene basalts that most probably cover Paleozoic–Mesozoic strata. Equivalent to onshore, the deeply buried section probably includes source rock and reservoir intervals of Carboniferous, Permian and Mesozoic age. Together with the major fault structures existing in the western part of the area, this may form the basis for a working petroleum system.
Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism
Authors: Xiao Wusheng , Oldham William M. , Priolo Carmen , Pandey Arvind K. , Loscalzo Joseph 
Published: April 2021

Rationale:
Specific mechanisms linking inflammation and metabolic reprogramming—two hallmarks of many pathobiological processes—remain incompletely defined.

Objective:
To delineate the integrative regulatory actions governing inflammation and metabolism in endothelial cells.

Methods and Results:

Metabolomic profiling, glucose labeling and tracing, and Seahorse extracellular flux analyses revealed that the inflammatory mediators, TNFα (tumor necrosis factor alpha) and lipopolysaccharide, extensively reprogram cellular metabolism and particularly enhance glycolysis, mitochondrial oxidative phosphorylation (OXPHOS), and the pentose phosphate pathway in primary human arterial endothelial cells. Mechanistically, the enhancement in glycolysis and pentose phosphate pathway is mediated by activation of the NF-κB (nuclear factor-kappa B)–PFKFB3 (6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase 3) axis and upregulation of G6PD (glucose 6-phosphate dehydrogenase), respectively, while enhanced OXPHOS was attributed to suppression of the FOXO1 (forkhead box O1)-PDK4 (pyruvate dehydrogenase kinase 4) axis. Restoration of the FOXO1-PDK4 axis attenuated the TNFα- or lipopolysaccharide-induced increase in OXPHOS but worsened inflammation in vitro, whereas enhancement of OXPHOS by pharmacological blockade of PDKs attenuated inflammation in mesenteric vessels of lipopolysaccharide-treated mice. Notably, suppression of
G6PD
expression or its activity potentiated the metabolic shift to glycolysis or endothelial inflammation, while inhibition of the NF-κB–PFKFB3 signaling, conversely, blunted the increased glycolysis or inflammation in in vitro and in vivo sepsis models.

Conclusions:
These results indicate that inflammatory mediators modulate the metabolic fates of glucose and that stimulation of glycolysis promotes inflammation, whereas enhancement of OXPHOS and the pentose phosphate pathway suppresses inflammation in the endothelium. Characterization of these immunometabolic phenotypes may have implications for the pathogenesis and treatment of many cardiovascular diseases.
Some Proposed Connections between the Visions of Amram and the Four Kingdoms in View of the Aramaic Literature from Qumran
Authors: Machiela Daniel A. 
Published: April 2021

Abstract
The Visions of Amram (4Q543–549) and Four Kingdoms (4Q552–553) are two Aramaic compositions from Qumran that have been recognized to contain apocalyptic dream-visions. In this article I propose some special connections between the dream-visions in these two works, centered on similar dialogues that take place between the seers in each text and characters seen in the dreams. These connections suggest that the Visions of Amram and Four Kingdoms emerged from a shared or closely related authorial setting. I also suggest that the connections discussed in this article are indicative of other literary affinities exhibited more generally among the Qumran Aramaic corpus, affinities that point toward a broader literary movement of which the Visions of Amram and Four Kingdoms were part.
Born of Woman, Fashioned from Clay
Authors: Meyer Nicholas A. 
Published: April 2021

Abstract
This essay traces the features of a symbolic construct which seldom garners much attention among scholars of biblical and Second Temple texts, including the Dead Sea Scrolls, namely, the likening of earth and womb. It contends that understanding this symbolism brings clarity to several texts whose interpretation is disputed and illuminates important aspects of sectarian thought, including a perspective on human sexuality which has escaped some current scholarship. The representation of the sexed body in the Thanksgiving Psalms (or “Hodayot”) receives extended attention. These psalms, it is shown, have been influenced by the negative rhetorical application of the phrase “born of woman” as found in the book of Job and by a tradition reflected in Jubilees and 4Q265 which employs the creation of Adam and Eve as a paradigm for the purification of new mothers (as described in Lev 12). The argument will show how a homology of earth and womb lies behind or can be derived from each of these traditions and how it comes to shape a profoundly negative, if highly contextualized, view of sexuality in the Psalms of Thanksgiving.
Ajax behind the skēnē
Authors: Catrambone Marco 
Published: April 2021

Abstract
This paper discusses problems of staging, address and word order in Greek tragedy to shed light on a controversial passage in Sophocles: Aj. 339-343. Ajax’s cry within, ἰὼ παῖ παῖ (339), has been alternatively taken to refer to Eurysaces (as suggested by Tecmessa) or to Teucer (whom Ajax mentions at 342-343). The paper argues for Teucer and responds to three arguments against this view: (1) παῖ is not only acceptable, but also effective to address one’s sibling; (2) the word order of 342, Τεῦκρον καλῶ, strictly implies ‘It’s Teucer I’m calling’ (not just: ‘I call on Teucer’), hence it cannot mark the move to a new addressee; (3) it is hardly possible for Ajax not to hear Tecmessa’s 340-341: short interactions across the skēnē door may occur, and the parallel scene at Euripides, Medea 1270a-1278 suggests that Ajax most likely hears Tecmessa’s words and corrects her wrong guess.
Aesthetic Experience and Creativity in Interactive Art
Authors: Savaş Esma Betül , Verwijmeren Thijs , van Lier Rob 
Published: April 2021

Abstract
Interactive art, which is art that relies on the participation of a spectator and in which the spectators enter the creative process, has changed the way people relate with artworks. An experiment was conducted in a laboratory with an interactive artwork (Temporal Perspectives by Doruk Kumkuoğlu and Sadettin Bilal Savaş, 2016) to investigate whether interactivity is a factor that plays a role in the aesthetic emotions and creativity of the spectator. The results indicated a significant increase in beauty, in response to interactive art. Partial correlational network analyses were conducted to further investigate the emotional experience of the artworks in both conditions. These analyses showed differences between the conditions in the emotional response to interactive art. However, cognitive flexibility of participants did not differ between conditions. The results indicate that interactivity should be taken into account as an element that affects the perception of art.
Plantation as Mission: American Indians, Enslaved Africans, and Jesuit Missionaries in Maryland
Authors: Masur Laura E. 
Published: April 2021

Abstract
Jesuit endeavors in Maryland are difficult to categorize as either missions or plantations. Archaeological sites associated with the Maryland Mission/ Province bear similarities to Jesuit mission sites in New France as well as plantations in Latin America and the Caribbean. It is clear that in Maryland, the Jesuits did not enforce a distinction between missions as places of conversion and plantations as sites of capitalist production. Moreover, people of American Indian, African, and European ancestry have been connected with Maryland’s Jesuit plantations throughout their history. Archaeological evidence of Indian missions in Maryland—however fragmented—contributes to a narrative of the Maryland mission that is at odds with prevailing nineteenth- and twentieth-century histories. Archaeology demonstrates the importance of critically reflecting on available historical evidence, including a historiographic focus on either mission or plantation, on the written history of Jesuits in the Americas. Furthermore, historical archaeologists must reconceptualize missions as both places and practices.
“The Grace of God and Virtue of Obedience”: The Archaeology of Slavery and the Jesuit Hacienda Systems of Nasca, Peru, 1619–1767
Authors: Weaver Brendan J. M. 
Published: April 2021

Abstract
Multi-scalar archaeological exploration offers new insights for understanding Jesuit estate systems and the slavery they depended on for agroindustrial production. Since 2009, ethnohistorical and archaeological research on two haciendas, San Joseph and San Francisco Xavier de la Nasca, in south coastal Peru’s Ingenio Valley, has illuminated the Jesuit institutions of slavery and the hacienda in colonial Peru. Belonging to two distinct Jesuit institutions, the estates supported schools in Cuzco and Lima, respectively. Since acquiring their first properties in Nasca in 1619, both colleges grew their haciendas by absorbing neighboring fields and noncontiguous lands throughout the region, becoming the largest, most profitable vineyards in the viceroyalty by the time of the expulsion of the Society of Jesus from the Spanish empire in 1767. Both hacienda administrations took similar approaches to property management and the large enslaved population that worked them, negotiating the cosmopolitanism of the communities and balancing obligations for evangelization and Christian discipline with the demands for agroindustrial production.
Strengthening influence of El Niño on the following spring precipitation over the Indo-China Peninsula
Authors: Li Gen , Gao Chujie , Xu Bei , Lu Bo , Chen Haishan , Ma Hedi , Li Xing 
Published: April 2021

AbstractEl Niño is a dominant source of interannual climate variability around the world. Based on the observed and reanalyzed datasets for the period of 1958-2019, this study explores the influence of El Niño on the spring precipitation over the Indo-China Peninsula (ICP). The results show that El Niño has a significant negative correlation with the following spring precipitation over the ICP. However, this climatic teleconnection of El Niño was unstable, with an obvious interdecadal strengthening since the early 1990s. During the decaying spring, the El Niño-related sea surface temperature (SST) anomalies would induce an abnormal downward motion along with an anomalous low-level anticyclone over the western North Pacific. Before the early 1990s, such El Niño-induced atmospheric circulation anomalies were located to the east of the ICP, exerting little influence on the spring ICP precipitation. In contrast, since the early 1990s, the abnormal downward motion and anomalous low-level anticyclone extended westwards covering the whole ICP, hampering local spring precipitation. This interdecadal change is owing to a relatively stronger intensity and longer duration of the El Niño-related warm SST anomalies over the tropical central Pacific in the epoch after the early 1990s (1992-2019) than in the previous decades (1958-1991). Our findings highlight a strengthening effect of El Niño on the following spring climate over the ICP since the early 1990s, which has great implications for the regional climate prediction.
Otolaryngologists’ Attitudes toward In-Office Pediatric Tympanostomy Tube Placement without General Anesthesia
Authors: Schild Sam D. , Rosenfeld Richard M. 
Published: April 2021

Objectives: Our objectives were to assess attitudes regarding office-based insertion of tympanostomy tubes without general anesthesia, to identify barriers that would discourage in-office procedures, and to highlight opportunities that would potentially facilitate this approach in the future. Methods: Cross-sectional survey administered to members of the American Society of Pediatric Otolaryngology (ASPO) from March to April 2020 using the Research Electronic Data Capture (Redcap), internet-based data capture platform. The brief, 10-item survey required 3 minutes to complete and used a 5-point Likert scale for primary questions. Results: Respondents included 172 fellowship trained, pediatric otolaryngologists with 14 median years of clinical practice and 25 median tympanostomy tube insertions per month (75% >40 per month). Although tubes, in any setting, were most often inserted in children under age 2 years (95% “often” or “very often”) and in those aged 3 to 5 years (93%), the likelihoods of doing this in-office for these age groups were only 8% and 6% respectively. For children aged 6 to 12 years, likelihood of in-office insertion was only 15%. Frequent barriers noted were safety concerns, emotional trauma, physical pain, and inability to suction. Opportunities to facilitate this approach include improved topical anesthesia, availability of conscious sedation, conclusive research on adverse effects of general anesthesia, and availability of an automated tube insertion device. Conclusion: Office-based insertion of tympanostomy tubes in children without general anesthesia is performed by a small minority of respondents, but there are discernible barriers and opportunities to promote future uptake. Our results should facilitate ongoing discussion and innovation to better accommodate the preferences of families whose children are candidates for tympanostomy tubes.
Predicting Gag, Discomfort, and Laryngeal Visualization in Patients Undergoing Flexible Laryngoscopy with Stroboscopy
Authors: Kiessling Patrick , Bayan Semirra , Lohse Christine , Orbelo Diana 
Published: April 2021

Objective: To investigate potential associations between the Predictive Gagging Survey (PGS) with patient experience of gag and discomfort as well as provider perception of patient gag and level of laryngeal visualization during flexible laryngoscopy with stroboscopy (FL-S). Methods: A total of 53 adult patients undergoing FL-S were recruited for this prospective non-controlled study. PGS was completed before FL-S. Patients rated perceived level of gag and discomfort on a 10-point severity scale after FL-S. Additionally, providers completed a Gagging Severity Index (GSI) reflecting their impression of patient gag and level of laryngeal visualization following FL-S. Spearman rank correlation coefficients were used to assess associations. Results: There was a positive association with PGS score and patient perception of gagging (0.34; P = .013) and patient perception of discomfort (0.38; P = .005). No significant association was found between PGS score and provider GSI (−0.12; P = .39) or level of laryngeal visualization (0.15; P = .29). A negative association was found between level of laryngeal visualization and patient perception of gagging (−0.34; P = .012) and discomfort (−0.44; P = .001). No significant differences were found between current and former smokers compared to never smokers for GSI or patient-perceived gag or discomfort. Conclusions: While not predictive of GSI or level of laryngeal visualization, the PGS was found to be a useful tool in predicting patient experience of gagging and discomfort during FL-S, further reinforcing the subjective experience of this procedure. Use of the PGS may be helpful in identifying specific candidates who may struggle with subjective discomfort or gagging during FL-S for future studies considering interventions to manage and meaningfully decrease discomfort. Having such an instrument is important given the low number of individuals who struggle with discomfort during the exam.
Discursive framing and organizational venues: mechanisms of artificial intelligence policy adoption
Authors: af Malmborg Frans , Trondal Jarle 
Published: April 2021

The purpose of this article is twofold: to theoretically assess ideational and organizational explanatory factors in the adoption of artificial intelligence policies; and to examine the extent to which the European Union has managed to facilitate a coordinated artificial intelligence policy in the Nordic countries. The study utilizes a mixed-methods approach based on systematic web searching, systematic policy document analysis and key informant semi-structured interviews. The study finds that the European Union has utilized framing-based strategies to set an agenda for a coordinated European artificial intelligence policy. Moreover, the strategy has affected member-state artificial intelligence policies to the extent that key tenets of European Union artificial intelligence discourse have penetrated Nordic public documents. However, the extent to which the Nordic countries incorporate European Union artificial intelligence policy discourse diverges at the national level. Differentiated national organizational capacities among Nordic countries make the adoption of artificial intelligence policies divergent. This observation is theoretically accounted for through a conversation between organizational theory of public governance and discursive institutionalism. The study argues that the framing of European Union artificial intelligence policies is filtered through organizational structures among states. Points for practitioners The study illuminates how policymakers in the Nordic countries are affected by the European Union when crafting their own artificial intelligence policies. The European Commission profoundly influences the policymaking of member states and affiliated states through the policy strategy of policy framing. The Commission uses this soft measure to nudge member states to comply with the European Union policy framework. Second, the study shows how ‘organizations matter’: variation in national organizational capacities in the Nordic states contributes to variation in national policy adoption. Even though Nordic countries adopt European Union-level policy frames, their implementation is shaped by varying organizational capacities available at the national level.