bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Incidence of Postoperative Hemorrhage in Vitreoretinal Surgery in Patients on Anti-Coagulants
Authors: Starr Matthew R. , Ammar Michael J. , Patel Luv G. , Boucher Nicholas , Yonekawa Yoshihiro , Garg Sunir J. , Hsu Jason , Ho Allen C. , Regillo Carl D. , Chiang Allen 
Published: July 2021

BACKGROUND AND OBJECTIVE:
Data regarding hemorrhagic complications of direct oral anticoagulants (DOACs) and vitreoretinal surgery are limited.

PATIENTS AND METHODS:
Multicenter analysis of longitudinal, aggregated electronic health records of patients undergoing pars plana vitrectomy (PPV) with no prior history of ocular hemorrhage. Retrospective analysis of patients undergoing PPV between January 1, 2013, and December 31, 2019. The main outcomes were development of postoperative hemorrhagic complications within 1 month following vitreoretinal surgery.

RESULTS:

A total of 58,131 eyes underwent PPV, with 2,956 (5.1%) on anticoagulant medication prior to surgery. Eight hundred twenty-eight eyes (1.4%) developed a postoperative hemorrhage. Of eyes with anticoagulation use, 50 of 2,956 (1.29%) developed a hemorrhage, whereas 778 of 55,175 (1.41%) of the eyes with no prior anticoagulation use developed a postoperative hemorrhage (
P
= .2107).

CONCLUSION:
Use of DOACs prior to vitreoretinal surgery does not appear to be associated with increased rates of postoperative intraocular hemorrhage.

[
Ophthalmic Surg Lasers Imaging Retina
. 2021;52:374–379.]
In-vitro evaluation of bactericidal activity of antiseptics and disinfectants commonly used in healthcare settings
Authors: Perera K. C. , Ekanayaka S. K. , Chandrasiri N. S. , Jayatilleke K. , Kottahachchi J. 
Published: July 2021

Introduction: Healthcare-associated infections are common problems found in healthcare systems in most of the countries. Proper use of antiseptics and disinfectants is useful in reducing the magnitude of such infections. The aim of this study was to evaluate the bactericidal effect of different concentrations of selected antiseptics and disinfectants. Methods: Bactericidal activity of different concentrations of antiseptics and disinfectants; isopropyl alcohol, povidone iodine, chlorhexidine gluconate, sodium hypochlorite, hypertonic saline, peracetic acid and mixture of 2-aminoethanol, dodecyl dimethyl ammonium chloride, potassium carbonate & bis(3-aminopropyl) dodecylamine were evaluated against nine strains of American Type Culture Collections and 11 strains isolated from the hospitals. Bacterial suspensions were prepared equal to 0.5 McFarland turbidity standards and 100 μl of each was mixed with 3 ml of antiseptic/ disinfectant solution. After desired contact time (1 minute, 15 minutes and 24 hours), 20 μl of reaction mixer was transferred into 4 ml of sterile physiological saline, mixed well and 20 μl of solution was evenly spread throughout Muller Hinton agar/ blood agar plates. Growth control was done using 3 ml of distilled water instead of 3 ml of antiseptic/ disinfectant solution. All plates incubated at 35oC ± 2oC for 18 – 24 hours. Colonies were counted and reduction percentage was calculated. Results: All concentrations of isopropyl alcohol, povidone iodine, chorhexidine, sodium hypochlorite, peracetic acid and the mixture of 2-aminoethanol, didecyldimethylammonium chloride, potassium carbonate and bis(3-aminopropyl)dodecylamine showed 100% bactericidal activities against all tested bacterial strains in1-minute contact time. Bactericidal activity of hypertonic saline was varied against tested bacterial strains with higher bactericidal activity against Gram positive organisms than Gram negative organisms. Conclusions: Currently using concentrations of antiseptics and disinfectants evaluated in this study have 100% bactericidal activity other than hypertonic saline.
NR4A3 Mediates Thymic Negative Selection
Authors: Boulet Salix , Odagiu Livia , Dong Mengqi , Lebel Marie-Ève , Daudelin Jean-François , Melichar Heather J , Labrecque Nathalie 
Published: July 2021

Abstract
Central tolerance aims to limit the production of T lymphocytes bearing TCR with high affinity for self-peptide presented by MHC molecules. The accumulation of thymocytes with such receptors is limited by negative selection or by diversion into alternative differentiation, including T regulatory cell commitment. A role for the orphan nuclear receptor NR4A3 in negative selection has been suggested, but its function in this process has never been investigated. We find that Nr4a3 transcription is upregulated in postselection double-positive thymocytes, particularly those that have received a strong selecting signal and are destined for negative selection. Indeed, we found an accumulation of cells bearing a negative selection phenotype in NR4A3-deficient mice as compared with wild-type controls, suggesting that Nr4a3 transcriptional induction is necessary to limit accumulation of self-reactive thymocytes. This is consistent with a decrease of cleaved caspase-3+–signaled thymocytes and more T regulatory and CD4+Foxp3−HELIOS+ cells in the NR4A3-deficient thymus. We further tested the role for NR4A3 in negative selection by reconstituting transgenic mice expressing the OVA Ag under the control of the insulin promoter with bone marrow cells from OT-I Nr4a3+/+ or OT-I Nr4a3−/− mice. Accumulation of autoreactive CD8 thymocytes and autoimmune diabetes developed only in the absence of NR4A3. Overall, our results demonstrate an important role for NR4A3 in T cell development.
Marital Adjustment as a Predictor of Quality of Life in Infertile Couples
Authors: Eghtedar Samereh , Asghari Elnaz , Aparnak Fatemeh-Sara , Asgarloo Zoleikha , Rasti Parinaz 
Published: July 2021

Introduction:
Quality of life of couples may be affected by infertility. Information about their quality of life can be used for developing health promotion programs by the nurses. The purpose of this study was to predict the factors that affect the quality of life of infertile couples based on marital adjustment, factors related to infertility, and background characteristics.

Methods:
In this descriptive correlational study, 131 women and 79 men referred to an infertility center were recruited using a convenience method. Data were collected using the quality of life and Spiner's marital adjustment questionnaires. Regression analysis was used for the data analysis through the SPSS software version 16.

Results:
The means of the females and males' age were 35.74 ± 6.11 years and 32.45 ± 5.72 years, respectively. Of variables with aP< 0.1 that entered the regression analysis, marital adjustment (β = −0.444, P < 0.001), gender (β = 0.138,P< 0.023), and insurance (β = 0.199,P< 0.001) accounted for 78% of the observed variance in the quality of life of the infertile couples.

Conclusion:
The results revealed that fundamental interventions are needed to improve the quality of life of infertile couples. Providing the necessary training when couples go to the infertility clinic and improving insurance coverage for infertility treatment is recommended based on the results.
A multicenter study on problematic pornography consumption
Authors: Kadavala Bhavin Naranbhai , Vasavada Disha Alkeshbhai , Kumar Parveen , Bhatt Renish Bhupenderabhai , Patel Vishal Kanaiyalal , Tiwari Deepak Sachidanand 
Published: July 2021

Introduction:
Internet pornography use is a sexual behavior, and it comprises a variety of online sexual activities, including watching pornography, online pornography exchange, and engaging in sex chats. Due to rise in Internet access and technologies, online pornography and other type of repetitive behaviors have increased. The current study was aimed to estimate the prevalence of problematic pornography consumption among undergraduate medical students.

Methods:
A multicenter, cross-sectional study was carried out at seven different centers of Gujarat from October 2020 to December 2020. Online structured questionnaire in two different parts: (1) Demographic details and usage pattern of pornography among students, (2) Problematic Pornography Consumption Scale was prepared and shared with all undergraduate students through designated faculty. Logistic regression analysis was used for problematic pornography consumption (as dependent variable) and other categorical variables as independent variables.

Results:
A total of 1926 participants completed the study. The prevalence of problematic pornography consumption among participants was 14.6% (95% confidence interval 12.4–16.1). Male participants and participants who are in a romantic relationship have higher problematic pornography consumption. Participants' gender (odds ratio OR = 3.562), relationship status (OR = 1.636), weekly (OR = 1.749), and daily (OR = 1.733) pornography consumption emerged as statistically significant with the problematic pornography consumption from the logistic regression analysis.

Conclusion:
Problematic pornography consumption is more prevalent among male under graduate medical students than females. It is important to educate the students about the potential harmful adverse effects of pornography and to develop a positive attitude toward sex.
Homology versus homotopy in rational fibrations
Authors: Amann Manuel 
Published: July 2021

Motivated by prominent problems like the Hilali conjecture, Yamaguchi– Yokura recently proposed certain estimates on the relations of the dimensions of rational homotopy and rational cohomology groups of fibre, base and total spaces in a fibration of rationally elliptic spaces.
In this article we prove these estimates in the category of formal elliptic spaces and, in general, whenever the total space in addition has positive Euler characteristic or has the rational homotopy type of a homogeneous manifold (respectively of a known example) of positive sectional curvature. Additionally, we provide general estimates approximating the conjectured ones.
Moreover, we suggest to study families of rationally elliptic spaces under certain asymptotics, and we discuss the conjectured estimates from this perspective for twostage spaces.
A importância do exercício físico em tempos de pandemia: uma revisão integrativa da literatura
Authors: Castro Lorena Karen de Morais Moura , Carvalho Mariana de Sousa Meneses , Freire Milena Viana , De Paiva Miguel Henrique Pereira , De Oliveira Aureliano Machado 
Published: July 2021

RESUMO
O estilo de vida ativo é de fundamental importância para manter a saúde, deve ser estimulada durante o período da pandemia devido aos muitos benefícios proporcionados pelo mesmo à saúde, principalmente ao sistema cardiovascular, metabólico e imunológico.

ABSTRACT
The active lifestyle is of fundamental importance to maintain health, and should be encouraged during the pandemic period due to the many benefits it provides to health, especially to the cardiovascular, metabolic, and immune systems.
Development and Validation of a Nutritional Risk Screening Scale for Stroke Patients
Authors: Xu Jihan , Juan Cao , Su Yongjing , Xie Xiaolan , jin Yuanyuan , Feng Jiezhen , Feiwen Huang , Huang Yongqing , Xiaoyan Zhang 
Published: July 2021

IntroductionStroke is a global health problem, and around 62% of stroke patients suffer from malnutrition due to dysphagia, eating speed, or stress response. This study aimed to develop a Nutritional Risk Screening Scale for Stroke Patients (NRSS-SP).Material and methodsIn the current study we construct a theoretical framework by combining stroke characteristics, the risk factors of malnutrition in stroke patients, and clinical experience. Then, using the Delphi method, we formed a pool for entries and combined the opinions and suggestions discussed by experts in a research team. Next, we collected all of the data and information, categorized, merged, and split the pool of entry items' contents. Finally, we formed a pretest scale comprising 11 items after scoring their importance.ResultsThe pretest NRSS-SP comprised 10 items in three fields: physical, psychological, and independence. The score was assigned to each factor according to the evaluation results. (e.g., Disease severity, serum albumin and dysphagia: Score 3, age ≥70 years: Score 1). The cumulative effect of four factors (depression, anxiety, serum level of albumin, and body mass index (BMI)) was 65.512%. The item-level Content Validity Index (CVI) of the NRSS-SP ranged from 0.081 to 1.000, and the scale-level CVI was 0.912. The coefficient of Cronbach’s α ranged from 0.822 to 0.911.ConclusionsAn NRSS-SP (including National Institutes of Health Stroke Scale score, BMI, serum level of albumin, recent weight loss, recent food intake, dysphagia, age, depression, anxiety, and Barthel Index) score ≥6.5 was classified as a malnourishment risk; an NRSS-SP score <6.5 denoted normal nutrition.
Panorama da produção científica sobre a redução de riscos de desastres no estado do Paraná
Authors: Batista Fernanda Enko dos Santos , Fonseca Murilo Noli da , Ferentz Larissa Maria da Silva , Pinheiro Eduardo Gomes , Stringari Danyelle 
Published: July 2021

Esse estudo teve como objetivo a sistematização dos artigos produzidos por instituições de ensino e pesquisa do estado do Paraná, referentes a temática de Redução de Riscos de Desastres. A pesquisa foi desenvolvida por meio de buscas em bancos de dados, como o Portal Capes, por palavras-chave contidas nas classificações COBRADE e CODAR. Foram analisados 581 artigos, pertencentes a 124 periódicos. Como resultado, a cronologia demonstrou que desde a primeira publicação, em 1970, há um aumento significativo de pesquisas nesta área a partir dos anos 2000, com maior pico em 2012. Além disto, os artigos encontrados foram subdivididos por palavras-chave, classificados e disponibilizados no Portal da Redesastre, com o intuito de facilitar o acesso para novos pesquisadores.
Preoperative Albumin Level is not Associated with Acute Kidney Injury After Pediatric Cardiac Surgery: A Retrospective Cohort
Authors: Ukil Isildak Fatma , Yavuz Yasemin , Savluk Omer Faruk , Cine Nihat , Uslu Ufuk 
Published: July 2021

Objectives: This study aimed to evaluate whether the development of acute kidney injury (AKI) was associated with preoperative albumin/prealbumin levels and other clinical features in pediatric patients who underwent open-heart surgery for congenital heart disease.
Patients and Methods: In this retrospective cohort, patients aged between 1 – 60 months who underwent open-heart surgery (complete correction surgery) with a diagnosis of congenital heart disease at the XXXXXX, between January 1, 2018 - December 31, 2020, were retrospectively included (n = 100). Patient demographics, diagnoses, surgical characteristics, and laboratory findings were recorded and analyzed.
Results: Mean age was 13.63 ± 12.05 (range 1.5 - 60) months. eGFR was decreased by more than 50% in 13% of the cases. Compared to the preoperative period, it was found that urea (24th and 48th hour) and creatinine levels increased significantly (p< 0.001, for each), and eGFR decreased significantly in the postoperative period (p< 0.001). Linear regression for eGFR value revealed that longer aortic cross-clamp time (ACCT) was associated with a greater decrease in eGFR (p= 0.046). Other variables included in the model, age (p= 0.128), gender (p= 0.358), RACHS (p= 0.865), body mass index (p= 0.862), prealbumin (p= 0.313), albumin (p= 0.806) and duration of cardiopulmonary bypass (p= 0.921) were found to be non-significant.
Conclusion: While there was no relationship between eGFR and preoperative albumin/prealbumin levels in patients who underwent cardiac surgery due to congenital heart disease, longer ACCT was found to be associated with decreased eGFR.
The relation of SYNTAX score with Carotid Plaque Morphology in Patients who Undergoing Coronary By-pass Surgery
Authors: Aksoy Suleyman Hilmi , Birdal Oğuzhan , Yurdaışık Işıl 
Published: July 2021

Objectives: Although there are many studies assessing the relationship between carotid artery ultrasound findings and coronary artery disease, the relationship between carotid plaque types and the complexity of coronary lesions is not assessed. We aimed to examine the relationship between the SYNTAX score and carotid plaque morphology.
Patients and Methods: We retrospectively screened patients who underwent carotid Ultrasound before the coronary artery bypass graft operation between 2015 and 2020. Syntax score was calculated by two independent interventional cardiologists with online SYNTAX score calculator (www.syntaxscore.com). The lesions of carotid arteries by ultrasound were classified as fibrous, calcific and mixed plaques.
Results: A total of 407 patients were enrolled. Median age was 65 (58-71) years and 81.6% of patients were male. We used multinomial logistic regression to test the association between plaque types and syntax score. The syntax score was associated with calcified plaque both in right (odds ratio 1.04, 95% CI 1.01-1.07, p=0.006) and left internal carotid artery (odds ratio 1.04, 95% CI 1.02-1.06, p=0.004). However, the syntax score was not associated with fibrous (odds ratio 0.97, 95% CI 0.94-1.01, p=0.155 for right and odds ratio 0.99, 95% CI 0.96-1.02, p=0.759 for left carotid artery) and mixed plaque types (odds ratio 1.02, 95% CI 0.98-1.06, p=0.168 for right and odds ratio 1.00, 95% CI 0.96-1.04, p=0.791 for left carotid artery).
Conclusion: Syntax score may provide an idea for carotid plaque morphology prediction. Especially higher SYNTAX score may be a predictor of calcific carotid plaque.
Market Conditions for Impact Investments as a Subsidiary of the Social Finance Model
Authors: Oxana Wieland 
Published: July 2021

In this paper, the author presents an overview of the development of socially oriented impact investing in country-specific markets as a development of the social finance model. This analysis focuses on socially responsible investing (SRI) or impact investing, which has experienced continuous growth in certain countries, including European (UK, particular Scandinavian) and US markets. The equity of social impact mutual fund markets has grown both in the number of funds and in the differentiation of the securities under the social finance model.
Despite the fact that socially responsible investments or impact investments still lack a uniform definition under social finance, it mainly refers to investments that emphasize social/ecological/ethical value over monetary return. In the academic literature, it is not clear whether the behavior of impact investors will be sustainable toward the social finance paradigm, as their investment decision about the monetary return should be motivated by their economic behavior. The author analyzes the economic conditions of the capital market that provide long-term institutional support for socially oriented investments.
FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP PERILAKU MAKAN PADA PENDERITA HIPERTENSI DI WILAYAH KERJA PUSKESMAS BANJARSARI METRO UTARA TAHUN 2013
Authors: Ludiana Ludiana 
Published: July 2021

Hipertensi adalah suatu keadaan di mana terjadi peningkatan tekanan darah di atas ambang batas normal yaitu apabila tekanan darah sistolik > 140 mmHg dan tekanan darah distolik > 90 mmHg. Prevalensi hipertensi di Indonesia mencapai 31,7% dari populasi pada usia 18 tahun ke atas. Penelitian ini bertujuan untuk mengetahui perilaku makan penderita hipertensi dan faktor-faktor yang mempengaruhinya di wilayah kerja Puskesmas Pujokerto Trimurjo Kabupaten Lampung Tengah. Jenis penelitian ini bersifat kuantitatif dengan pendekatan Studi Cross Sectional. Jumlah sampel yang digunakan sebanyak 140 responden. Informasi dari responden diperoleh menggunakan kuesioner. Hasil penelitian menunjukkan bahwa variable umur, jenis kelamin, status pekerjaan, tingkat pendidikan, persepsi dan paparan media secara statistik tidak terbukti berpengaruh terhadap perilaku makan penderita hipertensi. Sedangkan variabel yang terbukti berpengaruh terhadap perilaku makan penderita hipertensi meliputi Dukungan petugas kesehatan (p-value=0,001, OR=5,374 CI;95% 2,044-14,129), dukungan keluarga (p-value= 0,006, OR= 4,484 CI;95% 1,526-13,170), pengetahuan (p-value= 0.028, OR=4,488 CI;95% 1,171-17,195), dan sikap responden (p-value= 0,039, OR=2,997 CI;95% 1,056-8,510). Dukungan petugas kesehatan merupakan salah satu faktor yang paling signifikan dalam mempengaruhi perilaku makan penderita hipertensi. Oleh karena itu, diharapkan petugas kesehatan dapat meningkatkan program-program yang telah ada
HUBUNGAN USIA DAN JARAK KEHAMILAN DENGAN KEJADIAN ABORTUS
Authors: Fitri Nuri Luthfiatil 
Published: July 2021

Abortion as one of the causes of maternal death is a matter of great concern. According to the WHO estimated at 15% -50% of maternal deaths associated with abortion. In Southeast Asia the annual incidence of abortion reaches 4.2 million and in Indonesia it reaches 1.5 million. The purpose of this study is to know the correlations between age and gestational distance with the incidence of abortion in hospitals Jend. Ahmad Yani Metro in 2015. The type of analytic survey research using case control approach. The population in this study were all pregnant women who were treated in RSUD Jend. Ahmad Yani Metro in 2014, amounting to 518 people with samples taken as many as 260 people consisting of 130 people in the case group and 130 people for the control group. The analysis in this study used chi square test. The results of statistical tests showed that there was an association of age with abortus occurrence (p-value 0,000 OR 4.021; CI; 95%: 2,161-7,483), there was a correlation between pregnancy distance and abortus occurrence (p-value: 0,000, OR 3.955; CI; 95 %: 2,354-8,556). Research shows there is a correlations between age and gestational distance with the incidence of abortion.
KEYAKINAN PENGGUNA ALAT KONTRASEPSI DALAM RAHIM DALAM MENCEGAH KEHAMILAN
Authors: M Yusro Hadi , Prasetyowati Prasetyowati 
Published: July 2021

Pengguna Metode Kontrasepsi Jangka Panjang (MKJP) lebih rendah, dibanding pengguna kontrasepsinon MKJP seperti suntik dan pil. Tingginya PUS menggunakan alat kontrasepsi jangka pendek, membuat rentan terjadinya putus pakai (droup out). Peserta KB aktif jenis kontrasepsi suntik di Kota Metro sebanyak 7.784 (38,85%) tahun 2014. Peserta AKDR baru sebesar 31 (1,24%) dari seluruh peserta KB aktif selama tahun 2014. Tujuan penelitian menggali informasi tentang mengapa akseptor AKDR masih rendah. Penggunaan pertanyaan ”why dan how”, untuk memahami pengaruh lingkungan budaya tentang AKDR. Populasi seluruh akseptor KB di Hadimulyo Barat. Pengumpulan data dengan wawancara mendalam, focus group discussion dan observasi. Informan akseptor AKDR berjumlah 6 orang, diambil secara purposif dan Bidan Poskeskel Hadimulyo sebagai provider pelayanan KB. Analisis data dilakukan sesudah penelitian. Uji validitas, reliabilitas menggunakan triangulasi sumber, metode dan data. Hasil menunjukkan akseptor AKDR yakin bahwa AKDR bisa mencegah kehamilan, sedangkan akseptor Non AKDR dari unsur realita sebagian besar tidak yakin, unsur idealisme sebagian tidak yakin, dari unsur fleksibilitas sebagian tidak yakin. Saran agar tenaga kesehatan, baik provider maupun Penyuluh KB lebih banyak menggunakan pendekatan individual dalam mensosialisasikan AKDR, meyakinkan bahwa AKDR sebagai kontrasepsi yang efektif dan aman