The wide spectrum of COVID-19 neuropsychiatric complications within a multidisciplinary centre
Authors: Delorme Cécile , Houot Marion , Rosso Charlotte , Carvalho Stéphanie , Nedelec Thomas , Maatoug Redwan , Pitron Victor , Gassama Salimata , Sambin Sara , Bombois Stéphanie , Herlin Bastien , Ouvrard Gaëlle , Bruneteau Gaëlle , Hesters Adèle , Gales Ana Zenovia , Millet Bruno , Lamari Foudil , Lehericy Stéphane , Navarro Vincent , Rohaut Benjamin , Demeret Sophie , Maisonobe Thierry , Yger Marion , Degos Bertrand , Mariani Louise-Laure , Bouche Christophe , Dzierzynski Nathalie , Oquendo Bruno , Ketz Flora , Nguyen An-Hung , Kas Aurélie , Lubetzki Catherine , Delattre Jean-Yves , Corvol Jean-Christophe ,   CoCo-Neurosciences Study Group, Delorme Cecile , Corvol Jean-Christophe , Delattre Jean-Yves , Carvalho Stephanie , Sagnes Sandrine , Dubois Bruno , Navarro Vincent , Louapre Celine , Stojkovic Tanya , Idbaih Ahmed , Rosso Charlotte , Grabli David , Gales Ana Zenovia , Millet Bruno , Rohaut Benjamin , Bayen Eleonore , Dupont Sophie , Bruneteau Gaelle , Lehericy Stephane , Seilhean Danielle , Durr Alexandra , Lamari Foudil , Brochard Vanessa Batista , Lubetzki Catherine , Pradat-Diehl Pascale , Hoang-Xuan Khe , Fontaine Bertrand , Naccache Lionel , Fossati Philippe , Arnulf Isabelle , Carpentier Alexandre , Edel Yves , Robain Gilberte , Thoumie Philippe , Degos Bertrand , Sharshar Tarek , Alamowitch Sonia , Apartis-Bourdieu Emmanuelle , Peretti Charles-Siegried , Ursu Renata , Dzierzynski Nathalie , Bourron Kiyoka Kinugawa , Belmin Joel , Oquendo Bruno , Pautas Eric , Verny Marc , Samson Yves , Leder Sara , Leger Anne , Deltour Sandrine , Baronnet Flore , Bombois Stephanie , Touat Mehdi , Sanson Marc , Dehais Caroline , Houillier Caroline , Laigle-Donadey Florence , Psimaras Dimitri , Alenton Agusti , Younan Nadia , Villain Nicolas , del Mar Amador Maria , Mariani Louise-Laure , Mezouar Nicolas , Mangone Graziella , Meneret Aurelie , Hartmann Andreas , Tarrano Clement , Bendetowicz David , Pradat Pierre-François , Baulac Michel , Sambin Sara , Pichit Phintip , Chochon Florence , Hesters Adele , Herlin Bastien , Nguyen An Hung , Porcher Valerie , Demoule Alexandre , Morawiec Elise , Mayaux Julien , Faure Morgan , Ewenczyk Claire , Coarelli Giulia , Heinzmann Anna , Masingue Marion , Bassez Guillaume , An Isabelle , Worbe Yulia , Lambrecq Virginie , Debs Rabab , Musat Esteban Munoz , Lenglet Timothee , Lambrecq Virginie , Hanin Aurelie , Chougar Lydia , Shor Nathalia , Pyatigorskaya Nadya , Galanaud Damien , Leclercq Delphine , Demeret Sophie , Cao Albert , Marois Clemence , Weiss Nicolas , Gassama Salimata , Le Guennec Loic , Degos Vincent , Jacquens Alice , Similowski Thomas , Morelot-Panzini Capucine , Rotge Jean-Yves , Saudreau Bertrand , Pitron Victor , Sarni Nassim , Girault Nathalie , Maatoug Redwan , Leu Smaranda , Thivard Lionel , Mokhtari Karima , Plu Isabelle , Gonçalves Bruno , Bottin Laure , Yger Marion , Ouvrard Gaelle , Haddad Rebecca , Ketz Flora , Lafuente Carmelo , Oasi Christel , Megabarne Bruno , Herve Dominique , Salman Haysam , Rametti-Lacroux Armelle , Chalançon Alize , Herve Anais , Royer Hugo , Beauzor Florence , Maheo Valentine , Laganot Christelle , Minelli Camille , Fekete Aurelie , Grine Abel , Biet Marie , Hilab Rania , Besnard Aurore , Bouguerra Meriem , Goudard Gwen , Houairi Saida , Al-Youssef Saba , Pires Christine , Oukhedouma Anissa , Siuda-Krzywicka Katarzyna , Malkinson Tal Seidel , Agguini Hanane , Said Safia , Houot Marion 
Published: June 2021

AbstractA variety of neuropsychiatric complications has been described in association with COVID-19 infection. Large scale studies presenting a wider picture of these complications and their relative frequency are lacking. The objective of our study was to describe the spectrum of neurological and psychiatric complications in patients with COVID-19 seen in a multidisciplinary hospital centre over 6 months. We conducted a retrospective, observational study of all patients showing neurological or psychiatric symptoms in the context of COVID-19 seen in the medical and university neuroscience department of Assistance Publique Hopitaux de Paris—Sorbonne University. We collected demographic data, comorbidities, symptoms and severity of COVID-19 infection, neurological and psychiatric symptoms, neurological and psychiatric examination data and, when available, results from CSF analysis, MRI, EEG and EMG. A total of 249 COVID-19 patients with a de novo neurological or psychiatric manifestation were included in the database and 245 were included in the final analyses. One-hundred fourteen patients (47%) were admitted to the intensive care unit and 10 (4%) died. The most frequent neuropsychiatric complications diagnosed were encephalopathy (43%), critical illness polyneuropathy and myopathy (26%), isolated psychiatric disturbance (18%) and cerebrovascular disorders (16%). No patients showed CSF evidence of SARS-CoV-2. Encephalopathy was associated with older age and higher risk of death. Critical illness neuromyopathy was associated with an extended stay in the intensive care unit. The majority of these neuropsychiatric complications could be imputed to critical illness, intensive care and systemic inflammation, which contrasts with the paucity of more direct SARS-CoV-2-related complications or post-infection disorders.