bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metrics and quantification of power‐line and pipeline resiliency in integrated gas and power systems
Authors: Sang Maosheng , Ding Yi , Ding Ming , Bao Minglei , Wang Peng , Sun Lei 
Published: June 2021

AbstractDue to the increasing interactions between the natural gas system (NGS) and electric power system (EPS), the failures of power‐lines or gas pipelines in one system may influence another system and consequently trigger widespread disruptions. Hence, identifying these critical components and protecting them from malfunctions are essential to prevent the collapse of integrated gas and power systems (IGPSs). Considering the effects of both network topologies and operational features on the resiliency evaluation, a novel assessment framework is proposed in this paper to screen out critical power‐lines and gas pipelines. First, the framework of IGPSs is introduced and an optimal energy flow (OEF) model is constructed to quickly obtain the operation states under various disturbances. Furthermore, the resiliency metrics (RMs) are developed from structural and operational perspectives respectively. Specifically, structural RMs consider the coupling topologies to capture the structure‐related resiliency, while operational RMs analyse the resiliency related to gas and power flow to capture physical operation characteristics. Finally, an assessment algorithm synthesizing all the metrics is proposed to quantify the comprehensive resiliency, based on which critical power‐lines and pipelines (CPPs) can be detected. The effectiveness of the proposed approach is validated by an IGPS test system.
Short-Term Outcomes of the Grammont Reverse Shoulder Arthroplasty: Comparison between First and Second Generation Delta Prosthesis
Authors: Alberio Riccardo Luigi , Landrino Marco , Fornara Paolo , Grassi Federico Alberto 
Published: June 2021

AbstractPurpose This article compares short-term outcomes of two series of patients, who underwent reverse total shoulder arthroplasty (RTSA) with two different implants, both based on Grammont's principles: the Delta III (D-3) and the Delta Xtend (D-XT) prostheses.Methods The D-3 group included a consecutive series of 26 patients (mean age 75 years), that were treated between 2000 and 2006; the D-XT group included a consecutive series of 31 patients (mean age 72.5 years), for a total of 33 implants performed between 2011 and 2015. In both groups the most common diagnoses were cuff tear arthropathy (18 and 22 shoulders, respectively) and malunion of proximal humerus fractures (3 and 5). All procedures were performed by the same surgeon. Constant–Murley score (CMS) was used to assess clinical and functional outcomes. Radiographic evaluation included the true anteroposterior and axillary views.Results Twenty-three patients of the D-3 group and 22 patients (24 shoulders) of the D-XT group were evaluated at a mean follow-up of 42 months (range 26–84) and 44 months (range 26–66), respectively. Four complications occurred in the D-3 group (1 partial deltoid detachment, 1 dislocation, and 2 glenoid component loosening), while one early postoperative infection occurred in the D-XT group. Increases in elevation and CMS between preoperative and postoperative period were observed in both groups; only the D-XT group showed a slight improvement in rotations. The incidence of scapular notching was significantly different between the two groups: 100% for D-3 and 22.2% for D-XT in patients with a minimum follow-up of 5 years.Conclusion Prosthetic design evolution and greater acquaintance with this surgery have undoubtedly led to an improvement in short-term outcomes with second generation implants of RTSA. Future studies will have to ascertain whether newer implants, relying on biomechanical solutions alternative to Grammont's original concept, might provide additional advantages and minimize drawbacks.
Analysis of Pulmonary Surgery in Children and Adolescents in Germany: Who Is doing What?
Authors: Böckle Carla E. , Blaser Jochen , Schukfeh Nagoud , Zeidler Jan , Ure Benno M. , Dingemann Jens 
Published: June 2021

Abstract
Introduction In Germany, pediatric surgery is organized in a decentralized manner. A nationwide clinical registry does not exist. The aim of this research is to analyze the current status of pulmonary surgery in the country in respect of children and adolescents.
Materials and Methods Claims data have been extracted from two health insurance databases representing 34% of the German population. Operative diagnoses and procedures, as well as patients' characteristics, were recorded from 2016 to 2019.
Results The incidence of the four index diagnoses investigated matched the current literature in three of four entities. The main indications <8 years were congenital lung malformations (61%) and spontaneous pneumothorax at age 8 to 17 years (77%). Furthermore, 1,668 pediatric pulmonary procedures (0–17 years) were identified (668 pulmonary resections). Two age peaks were identified: 13% of patients were operated on before 1 year old and 50% of patients were between 15 and 17 years old. Video-assisted-thoracoscopic-surgery (VATS) for pulmonary resections was applied in 62% of cases. 96% of pulmonary resections in patients <1 year and 70% of pulmonary resections in children between 1 and 14 years were performed by pediatric surgeons. Of patients between 15 and 17 years old, only 14% were operated on in pediatric surgery. The estimated average pulmonary resection caseload was 3.2 cases per year and per institution for pediatric surgery and 1.5 for adult surgery.
Conclusion Indications for pulmonary surgery in children arise from rare diagnoses. In total, 66% of lung resections are performed in patients <1 year and >14 years. The majority of lung resections are performed as VATS. Patients ≤14 years are predominantly operated on by pediatric surgeons. The accessibility of pediatric pulmonary surgery is acceptable, but there is a low caseload per center.
Surgical Perspectives for Pediatric Theater Teams during the SARS-CoV-2 Pandemic and Beyond: Narrative Review and Mandatory Tasks Guidelines
Authors: Iacona Roberta , Chima Kiran , Kotecha Ami , Saxena Amulya 
Published: June 2021

AbstractThis is a narrative review during the ongoing coronavirus disease 2019 (COVID-19) pandemic to streamline workflow of pediatric surgical patients in operating theaters and for theater teams involved in their management. Pediatric patient anxiety in theaters, aspects of communication, and optimizing vision during surgery during the pandemic have also been addressed. The COVID-19 pandemic has led to the creation of pathways in the surgical management of patients. As the pandemic progressed, hospitals developed pathways to offer increased protection to staff during procedures. This narrative review provides a clear perspective in the management of pediatric patients in operating theaters. Guidelines received from National Health Authorities and Societies affiliated with surgery, endoscopic surgery, anesthesiology, and endoscopy were carefully reviewed regarding their recommendations and data emerging from reports on COVID-19 were selected to compile the pathways specific for pediatric patients and staff. The workflow pathways have been successfully implemented during the pandemic and include a section on patients for endoscopy as well as approach to endoscopic surgery and open procedures. Theater room ergonomics that were successful during the pandemic have been outlined along with identification of areas specific to the pediatric patient anxiety, interteam communication/identification, and visor-related vision. The guidelines used successfully during the pandemic for pediatric theater teams can be used or adapted for formulating local hospital guidelines in other centers that could be valuable in patient management beyond the pandemic.
Preventing depression in older people with multimorbidity: 24-month follow-up of a trial of internet-delivered cognitive behaviour therapy
Authors: Read Jennifer R , Sharpe Louise , Burton Amy L , Areán Patricia A , Raue Patrick J , McDonald Sarah , Titov Nickolai , Gandy Milena , Dear Blake F 
Published: June 2021

Abstract

Background
older people coping with the impacts of living with multimorbidity are at increased risk of developing a depressive disorder.

Objective
this article reports the 24-month results of a randomised controlled trial of an internet-delivered cognitive behaviour therapy, which aimed to test whether depressive disorders could be prevented in this population.

Participants
community-based participants aged 65 years and over, who had two or more chronic physical health conditions and were assessed as having no current depressive disorder.

Methods
in total, 302 participants were randomised to an 8-week, five-lesson, internet-delivered intervention program (n = 150) or treatment as usual (TAU, n = 152). The primary outcomes were cases of depressive disorder, assessed post-intervention and at 3-month intervals throughout the trial, and depressive symptoms, assessed at pre-intervention, post-intervention, 6, 12 and 24 months following the intervention.

Results
there were significantly fewer cases of depressive disorder in the intervention group (n = 23, 15%) compared with the TAU group (n = 41, 27%) during the 24 months after the intervention (χ2(1, N = 302) = 6.13, P = 0.013, odds ratio = 0.490 [95% confidence interval: 0.277, 0.867]), representing a 44% reduction in cases of depressive disorder. No differences were found on depressive symptoms at 24-month follow-up. Internet-delivered cognitive behaviour therapy had high engagement and acceptability.

Conclusions
the results provide support that depressive disorders can be prevented in older people with multimorbidity through participation in internet-delivered cognitive behaviour therapy. With access to internet-delivered interventions in clinical care settings increasing, this has implications for older patient care where multimorbidity is extremely common.
VII—Aristotle’s Hylomorphism Reconceived
Authors: Gill Mary Louise 
Published: June 2021

AbstractMetaphysics Θ treats potentiality (δύναμις) and actuality (ἐνέργεια), and many scholars think that Aristotle broaches these topics once he has answered his main questions in Ζ and Η. In Ζ he asked, what is primary being? After arguing in Ζ.1 that substance (οὐσία) is primary being—a being existentially, logically, and epistemologically prior to quantities and qualities and other categorial beings—he devotes the rest of the book to οὐσία itself, investigating what it is, to decide what entities count as primary substances. I differ from the leading interpretative consensus that ΖΗ adequately answer the questions about primary substance, and contend instead that Metaphysics Θ continues the same investigation as ΖΗ and, using δύναμις and ἐνέργεια as tools, arrives at a striking new conception of hylomorphism, different from that in ΖΗ, which enables Aristotle to defend the substantial primacy of living organisms consisting of matter and form.
On the inconsistency of matching without replacement
Authors: Sävje F 
Published: June 2021

Summary
The paper shows that matching without replacement on propensity scores produces estimators that generally are inconsistent for the average treatment effect of the treated. To achieve consistency, practitioners must either assume that no units exist with propensity scores greater than 1/2 or assume that there is no confounding among such units. The result is not driven by the use of propensity scores, and similar artifacts arise when matching on other scores as long as it is without replacement.
Action-related eye measures to assess surgical expertise
Authors: Zheng B , Jiang X , Bednarik R , Atkins M S 
Published: June 2021

AbstractBackgroundEye-tracking offers a new list of performance measures for surgeons. Previous studies of eye-tracking have reported that action-related fixation is a good measuring tool for elite task performers. Other measures, including early eye engagement to target and early eye disengagement from the previous subtask, were also reported to distinguish between different expertise levels. These parameters were examined during laparoscopic surgery simulations in the present study, with a goal to identify the most useful measures for distinguishing surgical expertise.MethodsSurgical operators, including experienced surgeons (expert), residents (intermediate), and university students (novice), were required to perform a laparoscopic task involving reaching, grasping, and loading, while their eye movements and performance videos were recorded. Spatiotemporal features of eye–hand coordination and action-related fixation were calculated and compared among the groups.ResultsThe study included five experienced surgeons, seven residents, and 14 novices. Overall, experts performed tasks faster than novices. Examining eye–hand coordination on each subtask, it was found that experts managed to disengage their eyes earlier from the previous subtask, whereas novices disengaged their eyes from previous subtask with a significant delay. Early eye engagement to the current subtask was observed for all operators. There was no difference in action-related fixation between experienced surgeons and novices. Disengage time was strongly associated with the surgical experience score of the operators, better than both early-engage time and action-related fixation.ConclusionThe spatiotemporal features of surgeons’ eye–hand coordination can be used to assess level of surgical experience.
“The Year of the Cheerleader Lawsuits”: Paradoxical Sensemaking and Postfeminism in Reporting on Gender-Based Harassment
Authors: Jarvis Caitlyn M , Welch Jessica R 
Published: June 2021

Abstract
In 2014, former cheerleaders from five separate National Football League (NFL) teams in the United States sought legal reparations for wage theft and gender-based harassment. Within these claims, the women sought to bring to light the culture of fear, mistreatment, and silence that they experienced while working within the NFL. Using reports on these lawsuits as a case study, this study critically examines the sensemaking strategies rooted in postfeminist sensibilities and constructed through Whiteness. In particular, through identifying three paradoxes—victim/accomplice; normalization/sensationalism; objective/subjective—we offer a critique of mediated sensemaking that is organized in and around postfeminist discourses of choice, sexuality, and subjectification. Theoretically, we engage Weick’s theory of sensemaking, while offering new insights into the nuanced ways in which gender-based harassment is discussed.
Requirement of CRMP2 Phosphorylation in Neuronal Migration of Developing Mouse Cerebral Cortex and Hippocampus and Redundant Roles of CRMP1 and CRMP4
Authors: Yamazaki Yuki , Moizumi Maho , Nagai Jun , Hatashita Yoshiki , Cai Tianhong , Kolattukudy Papachan , Inoue Takafumi , Goshima Yoshio , Ohshima Toshio 
Published: June 2021

Abstract
The mammalian cerebral cortex is characterized by a 6-layer structure, and proper neuronal migration is critical for its formation. Cyclin-dependent kinase 5 (Cdk5) has been shown to be a critical kinase for neuronal migration. Several Cdk5 substrates have been suggested to be involved in ordered neuronal migration. However, in vivo loss-of-function studies on the function of Cdk5 phosphorylation substrates in neuronal migration in the developing cerebral cortex have not been reported. In this study, we demonstrated that Cdk5-mediated phosphorylation of collapsing mediator protein (CRMP) 2 is critical for neuronal migration in the developing cerebral cortex with redundant functions of CRMP1 and CRMP4. The cerebral cortices of triple-mutant CRMP1 knock-out (KO); CRMP2 knock-in (KI)/KI; and CRMP4 KO mice showed disturbed positioning of layers II–V neurons in the cerebral cortex. Further experiments using bromodeoxyuridine birthdate-labeling and in utero electroporation implicated radial migration defects in cortical neurons. Ectopic neurons were detected around the CA1 region and dentate gyrus in CRMP1 KO; CRMP2 KI/KI; and CRMP4 KO mice. These results suggest the importance of CRMP2 phosphorylation by Cdk5 and redundancy of CRMP1 and CRMP4 in proper neuronal migration in the developing cerebral cortex and hippocampus.
Accelerating Analytics Using Improved Binary Particle Swarm Optimization for Discrete Feature Selection
Authors: Moorthy Rajalakshmi Shenbaga , Pabitha P 
Published: June 2021

Abstract
Feature selection, a combinatorial optimization problem, remains broadly applied in the area of Computational Learning with the aim to construct a model with reduced features so as to improve the performance of the model. Feature selection algorithm aims to identify admissible subgroup of features without sacrificing the accuracy of the model. This research works uses Improved Binary Particle Swarm Optimization (IBPSO) to optimally identify subset of features. The problem of stagnation, trapping in local optima and premature convergence of Binary Particle Swarm Optimization (BPSO) for solving discrete feature selection dispute has been tackled using IBPSO. IBPSO prevents the model from overfitting and also takes less computational time for constructing the model because of reduced feature subset. The sine function, cosine function, position of the random particle and linear decrement of inertial weight are integrated in IBPSO, which balances between exploration and exploitation to identify optimal subset of features. The linear decrement of inertial weight tends to do good level of exploration at the starting phase, whereas at the end it tends to exploit solution space to find the optimal subset of features that are more informative and thereby discarding redundant and irrelevant features. Experimentation is carried out on seven benchmarking datasets obtained from University of California, Irvine repository, which includes various real-world datasets for processing with machine learning algorithms. The proposed IBPSO is compared with conventional metaheuristic algorithms such as BPSO, Simulated Annealing, Ant Colony Optimization, Genetic Algorithm and other hybrid metaheuristic feature selection algorithms. The result proves that IBPSO maximizes the accuracy of the classifier together with maximum dimensionality reduction ratio. Also, statistical tests such as T-test, Wilcoxon signed-pair test are also carried out to demonstrate IBPSO is better than other algorithms taken for experimentation with confidence level of 0.05.
Profile and early outcomes of surgical reconstruction of coronary artery atresia in children
Authors: Li Hanmei , Wang Hailing , Lin Ye , Rui Lu , Li Shoujun 
Published: June 2021

Abstract

OBJECTIVES
Coronary artery atresia is a rare coronary artery anomaly in children and has a high rate of misdiagnosis. We aimed to summarize the profile and early outcomes after the surgical reconstruction of coronary artery atresia in children.

METHODS
A retrospective analysis was performed in 12 consecutive patients with coronary artery atresia who were admitted to the Department of Paediatric Cardiac Surgery of Fuwai Hospital between October 2016 and September 2020. Ten patients underwent surgical reconstruction of the coronary artery with the pulmonary artery anterior wall, and 8 patients underwent concomitant mitral valvuloplasty.

RESULTS
There were 6 females and 6 males, with an age of 1.75 years [interquartile range (IQR), 1.0–3.5] and weight of 10.0 kg (IQR, 8.9–14.75). There were 10 cases of left coronary artery atresia and 2 cases of right coronary artery atresia. All the patients were initially misdiagnosed in the outpatient clinic, but further nonselective coronary angiography confirmed the diagnosis of coronary artery atresia. In all 10 patients with mitral regurgitation, echocardiogram of the mitral valve chordae and papillary muscle revealed ischaemic changes. The clamp time was 89.0 min (IQR, 75.0–101.0), the pump time was 126.0 min (IQR, 119.0–132.0) and the intensive care unit stay time was 1.5 days (IQR, 1.0–3.0). No perioperative deaths were noted. After 9.5 months (IQR, 5.5–13.5) of follow-up, 2 patients with fractional shortening that significantly decreased to 14.1% and 14.8% died and 1 patient had moderate pericardial effusion that improved after treatment with oral diuretics. Coronary artery ultrasound and enhanced computed tomography showed a patent main coronary artery in all the patients.

CONCLUSIONS
Coronary artery atresia in children is often associated with mitral regurgitation, and mitral valve chordae and papillary muscle exhibit ischaemic changes. Coronary artery reconstruction is safe and effective in children with coronary artery atresia.
Greyzone myocardial fibrosis and ventricular arrhythmias in patients with a left ventricular ejection fraction &gt;35%
Authors: Zegard Abbasin , Okafor Osita , de Bono Joseph , Kalla Manish , Lencioni Mauro , Marshall Howard , Hudsmith Lucy , Qiu Tian , Steeds Richard , Stegemann Berthold , Leyva Francisco 
Published: June 2021

Abstract

Aims
To determine whether myocardial fibrosis and greyzone fibrosis (GZF) on cardiovascular magnetic resonance (CMR) is associated with ventricular arrhythmias in patients with coronary artery disease (CAD) and a left ventricular ejection fraction (LVEF) &gt;35%.

Methods and results
In this retrospective study of CAD patients, GZF mass using the 3SD method (GZF3SD) and total fibrosis mass using the 2SD method (TF2SD) on CMR were assessed in relation to the primary, combined endpoint of sudden cardiac death, ventricular tachycardia, ventricular fibrillation, or resuscitated cardiac arrest. Among 701 patients [age: 65.8 ± 12.3 years (mean ± SD)], 28 (3.99%) patients met the primary endpoint over 5.91 years (median; interquartile range 4.42–7.64). In competing risks analysis, a GZF3SD mass ≥5.0 g was strongly associated with the primary endpoint [subdistribution hazard ratio (sHR): 17.4 (95% confidence interval, CI 6.64–45.5); area under receiver operator characteristic curve (AUC): 0.85, P &lt; 0.001]. A weaker association was observed for TF2SD mass ≥23 g [sHR 10.4 (95% CI 4.22–25.8); AUC: 0.80, P &lt; 0.001]. The range of sHRs for GZF3SD mass (1–527) was wider than for TF2SD mass (1–37.6).

Conclusions
In CAD patients with an LVEF &gt;35%, GZF3SD mass was strongly associated with the arrhythmic endpoint. These findings hold promise for its use in identifying patients with CAD and an LVEF &gt;35% at risk of arrhythmic events.
Gene targeting using pre-assembled Cas9 ribonucleoprotein and split-marker recombination in Pleurotus ostreatus
Authors: Boontawon Tatpong , Nakazawa Takehito , Xu Haibo , Kawauchi Moriyuki , Sakamoto Masahiro , Honda Yoichi 
Published: June 2021

ABSTRACT
Until recently, classical breeding has been used to generate improved commercial mushroom strains; however, classical breeding remains to be laborious and time-consuming. In this study, we performed gene mutagenesis using Cas9 ribonucleoprotein (Cas9 RNP) as a plasmid-free genome editing in Pleurotus ostreatus, which is one of the most economically important cultivated mushrooms. The pre-assembled Cas9/sgRNA targeting pyrG was introduced into protoplasts of a wild-type monokaryotic P. ostreatus strain PC9, which resulted in a generation of strains exhibiting resistance to 5-fluoroorotic acid. Small insertions/deletions at the target site were identified using genomic PCR followed by sequencing. The results showed Cas9 RNP-assisted gene mutagenesis could be applied for the molecular breeding in P. ostreatus and in other edible mushroom strains. Furthermore, gene disruption via split-marker recombination using the Cas9 RNP system was also successfully demonstrated in wild-type P. ostreatus PC9. This method could overcome the disadvantages of NHEJ-deficiency in conventional studies with gene targeting, and also difficulty in gene targeting in various non-model agaricomycetes.