bluuebunny/crossref_metadata_2025_split huggingface dataset:
Team functioning and implementation of innovations in healthcare and human service settings: a systematic review protocol
Authors: McGuier Elizabeth A. , Kolko David J. , Klem Mary Lou , Feldman Jamie , Kinkler Grace , Diabes Matthew A. , Weingart Laurie R. , Wolk Courtney Benjamin 
Published: June 2021

Abstract
Background
Healthcare and human services increasingly rely on teams of individuals to deliver services. Implementation of evidence-based practices and other innovations in these settings requires teams to work together to change processes and behaviors. Accordingly, team functioning may be a key determinant of implementation outcomes. This systematic review will identify and summarize empirical research examining associations between team functioning and implementation outcomes in healthcare and human service settings.

Methods
We will conduct a comprehensive search of bibliographic databases (e.g., MEDLINE, PsycINFO, CINAHL, ERIC) for articles published from January 2000 or later. We will include peer-reviewed empirical articles and conference abstracts using quantitative, qualitative, or mixed methods. We will include experimental or observational studies that report on the implementation of an innovation in a healthcare or human service setting and examine associations between team functioning and implementation outcomes. Implementation outcomes of interest are acceptability, adoption, appropriateness, cost, feasibility, fidelity, penetration, and sustainability. Two reviewers will independently screen all titles/abstracts, review full-text articles, and extract data from included articles. We will use the Mixed Methods Appraisal Tool to assess methodological quality/bias and conduct a narrative synthesis without meta-analysis.

Discussion
Understanding how team functioning influences implementation outcomes will contribute to our understanding of team-level barriers and facilitators of change. The results of this systematic review will inform efforts to implement evidence-based practices in team-based service settings.

Systematic review registration
PROSPERO CRD42020220168
On generalized Ostrowski, Simpson and Trapezoidal type inequalities for co-ordinated convex functions via generalized fractional integrals
Authors: Budak Hüseyin , Hezenci Fatih , Kara Hasan 
Published: June 2021

AbstractIn this study, we prove an identity for twice partially differentiable mappings involving the double generalized fractional integral and some parameters. By using this established identity, we offer some generalized inequalities for differentiable co-ordinated convex functions with a rectangle in the plane$\mathbb{R} ^{2}$R2. Furthermore, by special choice of parameters in our main results, we obtain several well-known inequalities such as the Ostrowski inequality, trapezoidal inequality, and the Simpson inequality for Riemann and Riemann–Liouville fractional integrals.
Safety assessment of subtilisin QK in rats
Authors: Xiao Shuai , Hu Dingbang , Gao Ya , Ai Yang , Luo Sang , Chen Song , Wang Ben , Zhou Li , Dong Yanshan , Wang Yefu 
Published: June 2021

Abstract
Background
Subtilisin QK is a serine protease in the subtilisin family, and is fermented by Bacillus subtilis QK02. The fibrinolytic activity of subtilisin QK was measured by detecting low molecular weight degradation products using a spectrophotometric method developed by Japan Bio Science Laboratory Co., Ltd. Subtilisin QK powder can maintain its fibrinolytic activity for more than 24 months when it is stored at room temperature and protected from light. Our previous results showed that subtlisin QK directly degraded cross-linked fibrins in the fibrin plate assay and effectively inhibited thrombosis in the mouse thrombus model. The aim of this study was to determine the acute toxicity, potential subchronic toxicity, and safety pharmacology of subtilisin QK in Sprague–Dawley (SD) rats.

Methods
In the acute toxicity study, a single oral dose of 100,000 FU/kg was administered to 10 female and 10 male SD rats. In the 28-day subchronic toxicity, 60 female and 60 male SD rats were randomly assigned to four experimental groups (daily oral dose of 0, 2500, 7500 and 25,000 FU/kg). In the safety pharmacology study, 20 female and 20 male SD rats were randomly assigned to four experimental groups (single oral dose of 0, 500, 1500 and 5000 FU/kg).

Results
No death occurred and no adverse effects were observed in the acute toxicity study at a dose of 100,000 FU/kg. In the 28-day subchronic toxicity study, several hematological and blood biochemical parameters showed increases or decreases; however, due to the lack of a dose–response relationship, these differences were considered unrelated to treatment. In the safety pharmacology study, no adverse effects were observed on the central nervous of SD rats post-administration up to a dose of 5000 FU/kg subtilisin QK.

Conclusion
The results showed that oral consumption of subtilisin QK is of low toxicological concern. No adverse effects were observed at doses of 2500, 7500, and 25,000 FU/kg in the 28-day subchronic toxicity, and the no-observed-adverse-effect level (NOAEL) of subtilisin QK was 25,000 FU/kg.
Fast cluster-based computation of exact betweenness centrality in large graphs
Authors: Daniel Cecile , Furno Angelo , Goglia Lorenzo , Zimeo Eugenio 
Published: June 2021

AbstractNowadays a large amount of data is originated by complex systems, such as social networks, transportation systems, computer and service networks. These systems can be modeled by using graphs and studied by exploiting graph metrics, such as betweenness centrality (BC), a popular metric to analyze node centrality of graphs. In spite of its great potential, this metric requires long computation time, especially for large graphs. In this paper, we present a very fast algorithm to compute BC of undirected graphs by exploiting clustering. The algorithm leverages structural properties of graphs to find classes of equivalent nodes: by selecting one representative node for each class, we are able to compute BC by significantly reducing the number of single-source shortest path explorations adopted by Brandes’ algorithm. We formally prove the graph properties that we exploit to define the algorithm and present an implementation based on Scala for both sequential and parallel map-reduce executions. The experimental evaluation of both versions, conducted with synthetic and real graphs, reveals that our solution largely outperforms Brandes’ algorithm and significantly improves known heuristics.
The efficacy of a training program for social skills in reducing addictive Internet behaviors among Palestinian university students
Authors: Affouneh Saida , Mahamid Fayez Azez , Berte Denise Ziya , Shaqour Ali Z. , Shayeb Marouf 
Published: June 2021

Abstract
Background
For youth in geopolitically at-risk environments, such as Palestine, the issues related to Internet overuse and addictions are complex. Youth residing in the occupied territories of Palestine as in other highly militarized zones have high levels of environmental stressors (e.g., militarization, poverty, lack of employment opportunities, cultural pressures, etc.) and few chemical or social outlets such as alcohol, intoxicants, and leisure activities. As such, the easily accessible and unrestricted opportunities for stress-reducing social contact of social media can lead easily to excessive and maladaptive Internet use. Therefore, interventions directly aimed at awareness and education on how to manage Internet use are critical for addressing these issues in high risk populations.

Aims
The purpose of the current study was to test the efficacy of a time-limited group training program aimed at improving social skills and reducing addictive Internet behaviors among university students.

Methods and results
The sample consisted of 30 university students who self-reported high scores on an Internet addiction scale. Participants were randomly assigned to either wait list or treatment group (15 in each condition). Results demonstrated that using a social skills training program over an 8-week period improved the level of social skills and reduced addictive Internet behaviors significantly in those who experienced the intervention when compared with a wait list control group.

Conclusions
These findings support the implementation of time limited training programs targeting social skills and addictive patterns of Internet use with university students identified with high levels of Internet addictive behaviors.
Lidocaine and dexmedetomidine combined infusion as an alternative to propofol for sedation in colonoscopy
Authors: Ibrahim Tamer Hamed 
Published: June 2021

Abstract
Background
Colonoscopy is one of the commonly performed procedures for the diagnosis of colonic disorders. Several sedation regimens are administered during colonoscopy. To date, the propofol-based sedation regimen is commonly used, although it may have some risks. I studied the efficacy of dexmedetomidine–lidocaine combination as a substitution for propofol for sedation in colonoscopy procedures.
It is a prospective randomized controlled study; 62 patients were recruited and divided into two equal groups: group P is the propofol group which included patients who received sedation with IV propofol using a loading dose of 50–100 mg of propofol and were continued on propofol IV infusion 25–75 μg/kg/min and group D-L is the dexmedetomidine–lidocaine group where patients received a loading dose of dexmedetomidine 1 μg/kg infused over 10 min followed by infusion of dexmedetomidine 0.2–0.7 μg/kg/h and lidocaine 1 mg/kg IV followed by an infusion of 1.5 mg/kg/h. The primary outcome was the median patients’ satisfaction scores after recovery assessed by the Likert 5-item scoring system. Other outcomes included postprocedure pain score, mean arterial blood pressure, saturation, heart rate during the procedure, amount of fentanyl and midazolam used during the procedure, and the number of apneic attacks.

Results
Patients in both groups were satisfied by the procedure, and the median and 1st–3rd IQ satisfaction scores were 5 (4.0–5.0) in group P and 4 (4.0–5.0) in group D-L; however, this difference was statistically significant (P value = 0.014), reflecting more satisfaction in patients who received propofol. Patients in group D-L required significantly more doses of midazolam and fentanyl to achieve an adequate sedation score, had a more significant drop in heart rate, and had significantly more postoperative pain scores than those in group P. Patients in group P had significantly more apneic attacks and lower intraprocedural oxygen saturation levels than those in group D-L.

Conclusion
Dexmedetomidine–lidocaine combined IV infusion was found to be effective and safe for sedation in colonoscopy with less side effects in terms of apneic attacks and desaturation, although patient satisfaction was significantly higher in the propofol group, yet as per the sedation scores this was considered to be clinically non-significant.

Trial registration
The study was registered by the Australian New Zealand Clinical Trials Registry (trial ID: 12620000249954).
Co-thermal degradation characteristics of rice straw and sewage sludge
Authors: Ngo Thi Ngoc Lan Thao , Chiang Kung-Yuh 
Published: June 2021

AbstractCo-thermal treatment of binary biomass mixture is an alternative to enhance the refractory decomposition of biomass thermal degradation efficiency resulted in the synergistic reaction. Rice straw (RS) containing a large amount of fixed carbon (FC) is quite difficult to thermally decompose at a lower temperature. Considering the RS and sewage sludge (SS), co-thermal treatment for enhancing energy conversion efficiency was feasible. This study investigates the kinetic behaviors and gas evolution of RS, SS, and their blends under co-thermal decomposition processes using Thermogravimetric analysis combined with Fourier-Transform Infrared Spectroscopy (FTIR). The experimental results indicate that SS could enhance the volatile matter decomposition in RS co-thermal process at lower temperatures. Activation energy decreases from 53 to 49 kJ mol− 1 with an increase in SS addition from 50 to 80% under pyrolysis conditions. The major volatile components were aliphatic chains with double bonds, as well as carbonyl, hydroxyl, and C–H groups in organic compounds by FTIR identification. The tested materials characteristics in terms of volatile matter (VM)-to-FC ratio significantly affected the thermal degradation performance. Activation energy was decreased with increasing the VM/FC ratio. It implied that co-thermal reaction could be accelerated. In summary, the results could provide the important information for co-thermal treatment of SS and RS in application for commercial-scale plant design.
Effects of Tamiflu and Adamine on histology and ultrastructure of the liver of albino mice
Authors: El-Alfy Nagla Zaky Ibrahim , Sakr Samia Mohamed , Mahmoud Mahmoud Fathy , Omar Heba Ahmed 
Published: June 2021

Abstract
Background
Tamiflu (Oseltamivir) and Adamine (Amantadine HCl) are antiviral drugs which are used for prevention and treatment for influenza. The present study was carried out to evaluate the effect of Tamiflu and Adamine on the liver of adult male albino mice from the histological and ultrastructural points of views.

Results
Histological examination of liver sections treated with Tamiflu and Adamine included enlargement and congestion of central and hepatic veins in addition to erosion of their endothelial lining cells, cytoplasmic vacuolation of hepatocytes, pyknosis of their nuclei, and dilatation of hepatic sinusoid. The electron microscopic investigation illustrated mitochondrial swelling, fragmented rough endoplasmic reticulum, cytoplasmic vacuolation, the nuclei with irregular envelope and condensed heterochromatin, dilated microvilli in sinusoid, in addition to active Kupffer cells have many lysosomes and filopodia in its membrane.

Conclusion
The study suggested that both drugs induced histopathological and ultrastructural alterations in hepatic tissue. In conclusion, Tamiflu and Adamine have pathological effects on liver of albino mice (Mus musculus).
Cognitive impairments in Polish children and adolescents with perinatal HIV infection
Authors: Zielińska-Wieniawska Anna , Bielecki Maksymilian , Wolańczyk Tomasz , Coupland Urszula , Kruk Małgorzata , Marczyńska Magdalena , Srebnicki Tomasz , Bryńska Anita 
Published: June 2021

Cel pracyCelem realizowanego projektu była ocena częstości występowania zaburzeń poznawczych oraz ustalenie związków pomiędzy ich występowaniem a zmiennymi klinicznymi i socjodemograficznymi u dzieci i młodzieży z wertykalnym zakażeniem HIV.MetodaW badaniu udział wzięło: 50 dzieci z wrodzonym zakażeniem HIV (PHIV+), w wieku 6-18 lat, 24 zdrowych dzieci urodzonych przez matki zakażone HIV (PHEU) oraz 43 zdrowych dzieci zdrowych rodziców (HIV-nA). Do oceny zaburzeń poznawczych użyto baterii testów CANTAB Research Suite.WynikiU osób z grupy PHIV+ stwierdzono, istotnie gorsze wyniki w porównaniu z grupą HIV-nA w zakresie przełączania uwagi, elastyczności poznawczej, wykorzystywania informacji zwrotnych oraz pamięci roboczej, a w stosunku do grupy PHEU - dłuższy czas planowania podczas wykonania zadania. Analiza wyników dla grupy wiekowej 12-18 lat wskazuje na pogorszenie funkcji wykonawczych w grupie PHIV+ w stosunku do grupy HIV-nA, widoczne dla każdego z testów. Wyższy logarytm wiremii na początku wdrożonego leczenia ARV związany był ze słabszymi wynikami w zakresie korzystania z informacji zwrotnej, przerzutności uwagi i elastyczności poznawczej oraz z wolniejszym przetwarzaniem.WnioskiWyniki badań wskazują na gorsze funkcjonowanie poznawcze młodzieży PHIV+, przy czym deficyty te są związane z zaawansowaniem infekcji przed leczeniem oraz narastają wraz z czasem trwania neuroinfekcji.
Entrepreneurial Bricolage and New Product Development Performance in New Ventures: The Contingent Effects of Founding Team Involvement
Authors: Wang Xinchun , Yu Xiaoyu , Meng Xiaotong 
Published: June 2021

Abstract
New product development (NPD) performance is a key determinant of a new venture’s success. However, compared with established firms, new ventures often suffer from resource constraints when developing new products. Entrepreneurial bricolage is reported in the literature as an alternative strategic option that enables managers to overcome resource constraints when developing new products. However, because new ventures are often founded by an entrepreneurial team, the effectiveness and efficiency of using bricolage to improve NPD performance might be contingent on how the founding team plays its roles in this process. Using data from 323 new ventures in China, we find support for the critical role of entrepreneurial bricolage in improving NPD success under resource constraints. More importantly, our results reveal that the bricolage strategy is more likely to benefit a venture when the founding team is composed of members with diverse functional backgrounds and is not heavily involved in strategic decision-making.
Degradation of trypan blue dye using neutralized red mud in circulating fluidized bed reactor and its kinetics study
Authors: Manekar Sakshi , Mohapatra Titikshya , Thakur Chandrakant , Ghosh Prabir 
Published: June 2021

Abstract
Dye is a common pollutant present in many chemical industrial waste water. Advanced oxidation processes are widely used for dye degradation. In this study, the degradation of trypan blue dye was examined by Fenton process. Neutralized red mud catalyst was used as a source of ferrous ion for Fenton’s process. The dye degradation performance has been analyzed by using circulating fluidized-bed reactor. The influence of some key parameters such as pH, initial dye concentration, catalyst dosage and hydrogen peroxide concentration on the degradation of dye has been investigated. All the experiments were performed for 90 min. The initial dye concentration was taken as 1.56 × 10−5 and 2.60 × 10−5 mol L−1 and the amount of catalyst was varied from 0.5 to 0.7 gm/L. The hydrogen peroxide was taken in the ratio of 1:20 with the catalyst. The effect of pH was studied in the varying range from 3–5. It was found that the more the acidic pH, more will be the rate of degradation. The increase in pH results in the lower degradation rate. As the amount of catalyst was increased, the degradation rate got increased. The optimized results were obtained at pH 3, catalyst dosage of 0.7 gm/L and dye concentration of 1.56 × 10−5 mol L−1. Subsequently, the reaction kinetics of Fluidized-bed reactor was also studied.
Recent advances in nano-opto-electro-mechanical systems
Authors: Xu Nan , Cheng Ze-Di , Tang Jin-Dao , Lv Xiao-Min , Li Tong , Guo Meng-Lin , Wang You , Song Hai-Zhi , Zhou Qiang , Deng Guang-Wei 
Published: June 2021

Abstract
Nano-opto-electro-mechanical systems (NOEMS), considered as new platforms to study electronic and mechanical freedoms in the field of nanophotonics, have gained rapid progress in recent years. NOEMS offer exciting opportunities to manipulate information carriers using optical, electrical, and mechanical degrees of freedom, where the flow of light, dynamics of electrons, and mechanical vibration modes can be explored in both classical and quantum domains. By exploiting NOEMS concepts and technologies, high speed and low-power consumption switches, high-efficiency microwave-optical conversion devices, and multiple quantum information processing functions can be implemented through on-chip integration. This review will introduce the principles of NOEMS, summarize the recent developments, and important achievements, and give a prospect for the further applications and developments in this field.
Heritage Artefacts in the COVID-19 Era: The Aura and Authenticity of 3D Models
Authors: Cardozo Thiago Minete , Papadopoulos Costas 
Published: June 2021

AbstractMuseums have been increasingly investing in their digital presence. This became more pressing during the COVID-19 pandemic since heritage institutions had, on the one hand, to temporarily close their doors to visitors while, on the other, find ways to communicate their collections to the public. Virtual tours, revamped websites, and 3D models of cultural artefacts were only a few of the means that museums devised to create alternative ways of digital engagement and counteract the physical and social distancing measures. Although 3D models and collections provide novel ways to interact, visualise, and comprehend the materiality and sensoriality of physical objects, their mediation in digital forms misses essential elements that contribute to (virtual) visitor/user experience. This article explores three-dimensional digitisations of museum artefacts, particularly problematising their aura and authenticity in comparison to their physical counterparts. Building on several studies that have problematised these two concepts, this article establishes an exploratory framework aimed at evaluating the experience of aura and authenticity in 3D digitisations. This exploration allowed us to conclude that even though some aspects of aura and authenticity are intrinsically related to the physicality and materiality of the original, 3D models can still manifest aura and authenticity, as long as a series of parameters, including multimodal contextualisation, interactivity, and affective experiences are facilitated.
A Theoretical Framework for Informal 3D Rendered Analysis of the RomanLarariumfrom Apollonia-Arsuf
Authors: Schoueri Kelly Gillikin , Teixeira-Bastos Marcio 
Published: June 2021

AbstractDigital reconstruction and visualization of archaeological sites are beneficial not only for public edification and admiration, but they can also significantly contribute to the site interpretation process. By going beyond basic modeling scenarios, one can apply 3D analyses for accurately testing visibility and lighting parameters, among other aspects. Based on the results of these tests, further insights can be extrapolated about the lived experience of culturally specific ancient peoples. The case of a Roman “villa” at Apollonia-Arsuf in Israel presents the opportunity to apply these informal techniques to a household shrine, or niche-stylelararium, found within the building in order to ascertain sightline visibility based on the architectural plan and visual impact as a result of artificial illumination from ceramic lamps. This paper also considers how photorealistic visualizations aid in phenomenological areas of research through sensory archaeology and sense of place, which in turn encourages reflection on the political, social, and religious meanings of the built environment. When we combine the power and diverse applications of 3D visualization technology with decades of research about Roman architecture, culture, religion, and social norms, the result is a step closer to recreating archaeological remnants and, in turn, understanding the ancient experience.