bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Value and Role of miR-129-5p in Non-Alcoholic Fatty Liver
Disease
Authors: Wang Yuan , Feng Yujia , Li Hong , Zhang Han , Niu Qinghui , Liang Kun , Bian Cheng 
Published: September 2021

AbstractThis study was to evaluate the expression of miR-129–5p in non-alcoholic
fatty liver (NAFLD) patients and its clinical value and explore its regulatory
effect on insulin resistance (IR). A total of 117 NAFLD patients and 110 healthy
controls were included. The levels of miR-129-5p were detected by qRT-PCR. To
assess the diagnostic value of miR-129-5p for NAFLD, the receiver operating
characteristic curve (ROC) was established. C57Bl/6 mice were supplied
with high-fat diet to establish NAFLD model. Intraperitoneal insulin tolerance
test (IPITT) was carried out to evaluate the effect of miR-129-5p on IR in NAFLD
animal model. miR-129-5p was highly expressed in the serum of NAFLD patients,
and patients with HOMA-IR ≥2.5 had higher level of miR-129-5p than those
with HOMA-IR <2.5. miR-129-5p had the ability to differentiate NAFLD
patients from healthy individuals and might be associated with the development
of IR. Serum miR-129-5p was positively correlated with the levels of HOMA-IR,
BMI, total cholesterol (TC), and triglyceride (TG) in NAFLD patients.
Downregulation of miR-129-5p regulates lipid metabolism and insulin sensitivity
in NAFLD mice model. MiR-129-5p was upregulated in NAFLD patients and might be a
potential diagnostic biomarker. The regulatory effect of miR-129-5p on NAFLD may
function by regulating lipid accumulation and insulin sensitivity.
A Comprehensive PCOS Research and Guideline Translation Program to Improve Practice
Authors: Ramasamy Vijayanand A. , Garad Rhonda M. , Boyle Jacqueline A. 
Published: September 2021

AbstractPolycystic ovary syndrome (PCOS) is a common and complex endocrinopathy affecting reproductive-age women with a reported prevalence of 8 to 13%. To address the knowledge, practice, consumer satisfaction, and research gaps, an international research collaboration was formed to develop the first “International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome (2018).” This article describes an effective research translation program to disseminate the guideline internationally to women and health providers. To date, this had led to 75,197 views and almost 36,000 downloads of the PCOS guideline, and 43,000 views and 10,600 downloads of a suite of PCOS resources. AskPCOS app, the first freely accessible, evidence-based PCOS app, has 9,910 users (between 400 and 800 users per month), 23,447 sessions, and 87,801 screen viewings. Fifty-four percent of returning users are from across 137 countries, with the most users in Australia, the United States, the United Kingdom, the Netherlands, and India. Extensive global uptake of the PCOS guideline and compendium of resources was augmented by extensive formative consumer and health professional consultation, end-user engagement across the evidence-creation spectrum, co-design, and quality improvement.
Ganglioglioma Arising from the Septum Pellucidum
Authors: Shrestha Bishal , Gurung Pritam , Dhakal Sudan , Rajbhandari Pravesh , Basnet Ranga Bahadur , Pant Basant 
Published: September 2021

AbstractA 24-year-old gentleman presented to us with complaints of occasional headache for 2 years. Magnetic resonance imaging showed enhancing supra sellar mass with nonenhancing cystic components, extending superiorly up to the body of bilateral lateral ventricle, laterally displacing septum pellucidum, and compressing the third ventricle with obstructive hydrocephalus. Hormone profile depicted adrenocorticotropic hormone <5.00 pg/mL, growth hormone 1.32 ng/mL, insulin-like growth factor-1 <3.0 ng/mL. The patient underwent surgical resection. Histological finding was suggestive of ganglioglioma World Health Organization grade I. Customized immunohistochemistry panel was advised and revealed positive CD 56, NSE, and GFAP immunohistochemical stains. Gangliogliomas are less frequent neoplastic lesions confined to only a handful of case reports and studies. Accounting less than 2% of intracranial neoplasms, these lesions primarily affect those in the first 3 decades of their life. As ubiquitous it is in nature, we hereby present a case of ganglioglioma in a young adult male arising from septum pellucidum.
Bigger Bust No Longer on Trend: Malaysians Prefer Moderation in Ideal Female Breast Augmentation
Authors: Hamzan Muhammad Izzuddin , Sulaiman Wan Azman Wan , Ismail Nur Nadia 
Published: September 2021

AbstractBackground It is important to correctly determine the ideal female breast anatomy and aesthetic proportions in order to prepare for surgery and establish its goals. Leaving the preference to the operating surgeons alone might leave unsatisfactory results, which especially leads to reoperation, quite often in the aspect of breast dimension.Methods This study was conducted using an online graphic questionnaire. We attempted to seek male and female perspectives toward their preferred ideal female breast size for breast augmentation, in order to provide up-to-date data to assist breast surgeons in attaining satisfactory surgical results.Results Sixty males and 67 females participated in the study comprising Asian major ethnicities of Malay, Chinese, and Indian. Universally, 46.6% of men and 53.5% of women preferred 30 mm diameter for the most ideal nipple-areola complex (NAC) size. For the perfect bust, they generally favored size C and D cup (37.8% and 38.5%, respectively).Conclusion The majority of women seek natural breast beauty and the longing for an oversized look appears to have infiltrated practice but these assumptions have finally been challenged by these findings.
Prospective, Randomized Clinical Trial Comparing a Novel Motion-Assistive Device to Standard Physical Therapy for Initial Management of Knee Range of Motion after Primary Total Knee Arthroplasty
Authors: Cook James L. , Rucinski Kylee , Crecelius Cory R. , Cunningham Suzin , Guess Trent M. 
Published: September 2021

AbstractThis prospective randomized clinical trial assessed a novel device for initial management of knee range of motion (ROM), pain, and function after total knee arthroplasty (TKA). Primary TKA patients with preoperative ROM of at least 5° to 115° were randomized to initial knee motion management: Mizzou BioJoint Flex—novel motion-assistive device with prescribed physical therapy or standard physical therapy—prescribed physical therapy. ROM, pain score, and knee injury and osteoarthritis score for joint replacement (KOOSjr) were obtained preoperatively and 2 weeks, 6 weeks, and 3 months postoperatively. Patient satisfaction for both cohorts and subjective assessments of the MBF device were assessed at 3 months. Readmissions, reoperations, and complications were assessed through 1 year. Nineteen patients were randomized to each cohort, with no significant preoperative differences in demographics, pain score, KOOSjr score, or ROM. Six SPT (31.6%) and 3 MBF (15.8%) patients failed to regain preoperative ROM (p = 0.044). One SPT (5.3%) and eight MBF (42%) patients exceeded 125° ROM (p = 0.019) by 3 months. Total ROM (p = 0.039), pain (p = 0.0068), and function (p = 0.0027) were significantly better for MBF at 3 months. MBF patients reported significantly higher satisfaction (mean, 9.4 ± 1.1 vs. 8.0 ± 1.8, respectively; p = 0.0084). One patient in each group underwent manipulation under anesthesia. No other readmissions, reoperations, or complications were reported. A novel durable medical equipment device can provide a safe and effective patient-controlled method for initial management of knee ROM, pain, and function after primary TKA with potential clinically meaningful advantages over physical therapy alone. In conjunction with physical therapy, management with this novel knee flexion device more effectively restored knee ROM and early patient function when compared with therapy alone and was associated with higher proportions of patients regaining minimum (115°) and desired (125°) levels of knee ROM and clinically meaningful differences in pain scores, knee function, and patient satisfaction. This is a Level 1, prospective trial study.
Genetic and Epigenetic Alterations in Autism Spectrum Disorder
Authors: Oztenekecioglu Bugsem , Mavis Merdiye , Osum Meryem , Kalkan Rasime 
Published: September 2021

AbstractIt is extremely important to understand the causes of autism spectrum disorder (ASD) which is a neurodevelopmental disease. Treatment and lifelong support of autism are also important to improve the patient's life quality. In this article, several findings were explained to understand the possible causes of ASD. We draw, outline, and describe ASD and its relation with the epigenetic mechanisms. Here, we discuss, several different factors leading to ASD such as environmental, epigenetic, and genetic factors.
A membrane protein display platform for receptor interactome discovery
Authors: Cao Shengya , Peterson Sean M. , Müller Sören , Reichelt Mike , McRoberts Amador Christian , Martinez-Martin Nadia 
Published: September 2021

Significance
Membrane proteins and their interactions are major drug targets because of their central roles in regulating cellular communication and signal transduction. Despite this, membrane receptors remain underrepresented in our knowledge base of protein–protein interactions because of the limitations of most available techniques. Here, we developed a vesicle-based membrane-protein display platform as a fast, reproducible, and broadly applicable method for unbiased receptor–ligand interaction discovery. Using this technology, we elucidated known and new single-pass transmembrane-binding partners for several immune checkpoint molecules as well as an architecturally distinct single-pass transmembrane protein that has resisted deorphanization by existing techniques. This method is well suited for extracellular protein interaction discovery for difficult-to-purify membrane proteins and whole vesicles.
A mechanism for Rad53 to couple leading- and lagging-strand DNA synthesis under replication stress in budding yeast
Authors: Serra-Cardona Albert , Yu Chuanhe , Zhang Xinmin , Hua Xu , Yao Yuan , Zhou Jiaqi , Gan Haiyun , Zhang Zhiguo 
Published: September 2021

Significance
During the S phase of the cell cycle, the DNA replication machinery accurately duplicates the genome in spite of numerous hurdles that cause replication stress. The replication checkpoint pathway deals with the replication stress, which, if left undealt with, can lead to fork collapse and genome instability, a process that remains poorly understood. Here, we show that the DNA checkpoint pathway couples leading- and lagging-strand DNA synthesis to prevent the generation of deleterious single-stranded DNA under replication stress by attenuating the replication function of Mrc1, a protein involved in both DNA replication and replication checkpoint, providing a mechanistic insight into how eukaryotic cells overcome replication stress.
Challenging the triadic dialogue format
Authors: Margutti Piera 
Published: September 2021

Abstract
Building on previous work focusing on teachers’ questions in whole-class activities in an Italian primary school, this study focuses on pupils’ responses in interactions organised according to the ‘triadic dialogue’ format (Lemke 1990), also known as the Initiation-Response-Evaluation (Sinclair and Coulthard 1975; McHoul 1978; Mehan 1979). The results show that the second position is a place where pupils perform many different actions. Using Conversation Analysis, it is argued that pupils follow two main and conflicting principles, associated with the institutional nature of interactions: being first to answer and being respectful of the classroom turn-taking system. By examining the features of turn design and the overlapping onset of answers, an interactional account of answering as a social, public, and conjoined activity is provided.
Facilitating children’s elicitation of interlaced narratives in classroom interactions
Authors: Baraldi Claudio 
Published: September 2021

Abstract
This chapter is based on the analysis of interactions that were video-recorded during 66 meetings in 24 (years 4 to 7) classrooms in five Italian schools. These meetings are part of a project aiming to collect personal photos regarding children’s memories and to use them to facilitate the production of narratives around children’s memories in classroom interactions. This chapter focuses on the facilitation of interlaced narratives, i.e. new narratives elicited through children’s responses to an initial narrative. The analysis concerns the ways in which facilitative actions enhance (or do not enhance) interlaced narratives, and the interactional structures that allow (or do not allow) children to elicit new narratives, that is, to move from a child’s initial narrative to other children’s narratives.
Minimodel of semantic synthesis of Russian sentences
Authors: Iordanskaja Lidija , Mel’čuk Igor 
Published: September 2021

Abstract
A formal linguistitic model is presented, which produces, for a given conceptual representation of an extralinguistic
situation, a corresponding semantic representation [SemR] that, in its turn, underlies the deep-syntactic representations of four
near-synonymous Russian sentences expressing the starting information. Two full-fledged lexical entries are given for the lexemes
besporjadki ‘disturbance’ and stolknovenie ‘clash(N)’, appearing in these sentences. Some principles of
lexicalization – that is, matching the formal lexicographic definitions to the starting semantic representation in order to produce the
deep-syntactic structures of the corresponding sentences – are formulated and illustrated; the problem of approximate matching is dealt with
in sufficient detail.
Hemodynamic response and pulse wave analysis after upper‐ and lower‐body resistance exercise with and without blood flow restriction
Authors: Tai Yu Lun , Marshall Erica M. , Parks Jason C. , Kingsley J. Derek 
Published: September 2021

ABSTRACTResistance exercise (RE) has been shown to elevate hemodynamics and pulse wave reflection. However, the effects of acute RE with blood flow restriction (BFR) on hemodynamics and pulse wave reflection are unclear. The purpose of this study was to evaluate the differences between upper‐ and lower‐body RE with and without BFR on hemodynamics and pulse wave reflection. Twenty‐three young resistance‐trained individuals volunteered for the study. Hemodynamics and pulse wave reflection were assessed at rest, 10, 25, 40, and 55 min after either upper‐ or lower‐body with or without BFR. The upper‐body RE (URE) consisted of the latissimus dorsi pulldown and chest press; the lower‐body RE (LRE) consisted of knee extension and knee flexion. The BFR condition consisted of four sets of 30, 15, 15, and 15 repetitions at 30% 1‐repetition maximum (1RM) while the without BFR condition consisted of four sets of 8 repetitions at 70% 1RM. Heart rate, rate pressure product, and subendocardial viability ratio significantly (p < 0.05) increased after all exercises. Brachial and aortic systolic blood pressure (BP) significantly (p < 0.05) elevated after LRE while brachial and aortic diastolic BP significantly (p < 0.05) reduced after URE. Augmentation pressure, augmentation index (AIx), AIx normalized at 75 bpm, and wasted left ventricular pressure energy significantly (p < 0.05) increased after URE while transit time of reflected wave significantly (p < 0.05) decreased after LRE. URE places greater stress on pulse wave reflection while LRE results in greater responses in BP. Regardless of URE or LRE, the cardiovascular responses between BFR and without BFR are similar.HIGHLIGHTS
High‐load resistance exercise and low‐load resistance exercise with blood flow restriction may produce similar cardiovascular responses.
Upper‐body resistance exercise generates greater changes on pulse wave reflections while lower‐body resistance exercise induces greater elevations in systolic blood pressure.
Inverse problem of reconstruction of degenerate diffusion coefficient in a parabolic equation
Authors: Cannarsa Piermarco , Doubova Anna , Yamamoto Masahiro 
Published: September 2021

Abstract
We consider the inverse problem of identification of degenerate diffusion coefficient of the form x

α

a(x) in a one dimensional parabolic equation by some extra data. We first prove by energy methods the uniqueness and Lipschitz stability results for the identification of a constant coefficient a and the power α by knowing interior data at some time. On the other hand, we obtain the uniqueness result for the identification of a general diffusion coefficients a(x) and also the power α form boundary data on one side of the space interval. The proof is based on global Carleman estimates for a hyperbolic problem and an inversion of the integral transform similar to the Laplace transform. Finally, the theoretical results are satisfactory verified by numerically experiments.
RETRACTED: Measuring blood pressure from Korotkoff sounds as the brachial cuff inflates on average provides higher values than when the cuff deflates
Authors: Celler Branko G , Argha Ahmadreza 
Published: September 2021

Abstract

Objective. In this study, we test the hypothesis that if, as demonstrated in a previous study, brachial arteries exhibit hysteresis as the occluding cuff is deflated and fail to open until cuff pressure (CP) is well below true intra-arterial blood pressure (IABP). Approach Estimating systolic (SBP) and diastolic blood pressure (DBP) from the presence of Korotkoff sounds as CP increases may eliminate these errors and give more accurate estimates of SBP relative to IABP readings. Main Results. In 63 subjects of varying age 45.4 ± 19.9 years (range 21–76 years), including 44 men (45.2 ± 19.5, range 21–76 years) and 19 women (45.6 ± 21.4, range 21–75 years), there was a significant (p < 0.0001) increase in SBP from 124.4 ± 15.7 to 129.2 ± 16.3 mmHg and a significant (p < 0.0001) increase in DBP from 70.2 ± 10.7 to 73.6 ± 11.5 mmHg. Of the 63 subjects, 59 showed a positive increase in SBP (1–19 mmHg) and 5 subjects showed a reduction (−5 to −1 mmHg). The average differences for SBP estimates derived as the cuff inflates and estimates derived as the cuff deflates were 4.9 ± 4.7 mmHg, not dissimilar to the differences observed between IABP and NIBP measurements. Although we could not develop multiparameter linear or nonlinear models to explain this phenomenon we have clearly demonstrated through analysis of variance test that both body mass index (BMI) and pulse wave velocity are implicated, supporting the hypothesis that the phenomenon is associated with age, higher BMI and stiffer arteries. Significance. The implications of this study are potentially profound requiring the implementation of a new paradigm for NIBP measurement and a revision of the international standards for their calibration.
Doped MgAl2O4 semiconductor host nanopowders for tunable primary color emissions for application as white LEDs
Authors: Ain Qurat Ul , Ismail Bushra , Khan Asad Muhammad , Khan Rafaqat Ali , Shah Faheem , Rehman Hafiz-Ur , Shahid Farkhanda 
Published: September 2021

Abstract
The emission of white light from hosts having a single phase and the compromised applicability of a very inert, chemically stable, and structurally diverse MgAl2O4 led to a quest for improving the structural, optical, thermal and electrical properties for more innovative applications. A slight modification in lattice site occupation can lead to antisite defects which alter the physical properties of the materials. The presence of larger alkaline earth Sr2+ cations at the T-sites have been found to improve the behavior of the activator Mn2+ cations which are substituted for Mg2+ at T-sites. In the current study, a series of Mn2+ doped derivatives having a general formula of Mg1−x−0.3Mn
x
Sr0.3Al2O4 (x = 0.1–0.5) were synthesized using the chemical co-precipitation method. Due to the larger radius of Sr2+ cations, the lattice strain was observed in the cubic crystal structure of magnesium aluminate spinel (MAS). A decrease in the bandgaps of the doped samples indicates the formation of defect states within the bandgap of MAS. Apart from the bandgap transitions, the capture of electrons at oxygen vacancies is also observed in the UV/Vis spectra. The strong tetrahedral site preference of Mn2+ is altered by the presence of Sr2+, hence, some octahedral site occupation of Mn2+ in the lattice is achieved. The antisite defects along with the occupation of both T- and O-sites by Mn2+ resulted in novel emission bands centered at 464 nm (blue), 515 nm (green), and 621 nm (red) at λ
ex of 380 nm. The emission of the primary colors in a simple lattice with cost-effective and in-toxic constituents can be a possible alternative to the costly rare-earth ions doped complex materials in use to-date.
Assessing the Distinct Factors Driving Violent, Drug and Disorder-Related Prison Misconduct from Longitudinal Data in Northern Ireland
Authors: Butler Michelle , McNamee Catherine B , Kelly Dominic 
Published: September 2021

Abstract
Studies are increasingly interested in how different categories of prison misconduct may affect reoffending. Yet few studies investigate the distinct factors driving different types of misconduct and those that do are often cross-sectional or retrospective. This study uses a prospective longitudinal design to address this gap by investigating what factors influence future involvement in misconduct and if these factors vary by type. Administrative data drawn from the records of 429 imprisoned men are examined to predict misconduct during a 1-year follow-up period. Findings reveal distinct differences by type and suggestions for targeted support and tailored interventions are made to help prevent future infractions within, and potentially after, incarceration.
Mental well-being and quality of working life in UK social workers before and during the COVID-19 pandemic: A propensity score matching study
Authors: McFadden Paula , Neill Ruth D , Mallett John , Manthorpe Jill , Gillen Patricia , Moriarty John , Currie Denise , Schroder Heike , Ravalier Jermaine , Nicholl Patricia , Ross Jana 
Published: September 2021

Abstract
During the COVID-19 pandemic interest into its potential impact on mental well-being has intensified. Within the social care sector, the pandemic has increased job demands and prolonged stress taking a disproportionate toll on the workforce, particularly social workers. This article compares the mental well-being and quality of working life of social workers in the United Kingdom (UK) before and during the pandemic. Data were collected in 2018 (N = 1,195) and 2020 (N = 1,024) using two cross-sectional surveys. To account for the differences between the datasets, propensity score matching was employed prior to effect estimation, utilising demographic and work-related variables common to both datasets. The differences between the two time-points were estimated using multiple regressions. Both mental well-being and quality of working life were significantly higher during the COVID-19 pandemic in 2020 compared to 2018. This suggests that during the highpoint of the pandemic in the UK, increased support, and changes to working practices, such as reprioritisation of work and other initiatives, may be responsible for increased mental well-being and quality of working life. While acknowledging the known pressures on UK social workers during the COVID-19 pandemic this evidence suggests a mixed picture of the pandemic with lessons for managers and employers.