bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors associated with shortened latency before delivery in outpatients managed for preterm prelabor rupture of membranes
Authors: Point Florian , Ghesquiere Louise , Drumez Elodie , Petit Céline , Subtil Damien , Houfflin‐Debarge Véronique , Garabedian Charles 
Published: November 2021

AbstractIntroductionPreterm prelabor rupture of membranes (PPROM) occurs in 3% of pregnancies and is the main cause (~30%) of premature delivery. Home care seems to be a safe alternative for the management of patients with PPROM, who have a longer latency than those with PPROM managed with conventional hospitalization. We aimed to identify the risk factors associated with a shortened latency before delivery in women with PPROM managed as outpatients.Material and methodsThe design was a retrospective cohort study and the setting was a Monocentric Tertiary centre (Lille University Hospital, France) from 2009 to 2018. All consecutive patients in home care after PPROM at 24–36 weeks were included. For the main outcome measure we calculated the latency ratio for each patient as the ratio of the real latency period to the expected latency period, expressed as a percentage. The risk factors influencing this latency ratio were evaluated.ResultsA total of 234 patients were managed at home after PPROM. Mean latency was 35.5 ± 20.7 days, corresponding to an 80% latency ratio. In 196 (83.8%) patients the length of home care was more than 7 days. A lower latency ratio was significantly associated with oligohydramnios (p < 0.001), gestational age at PPROM (p = 0.006), leukocyte count at PPROM more than 12 × 109/L (p = 0.025), and C‐reactive protein concentration more than 5 mg/L at 7 days after PPROM (p = 0.046). Cervical length was not associated with a lower latency ratio.ConclusionsWomen with PPROM managed with home care are stable. The main risk factor associated with a reduced latency is oligohydramnios. Outpatients with oligohydramnios should be informed of the probability of a shortened latency period.
YouTube videos in Japanese as a source of information on nocturnal enuresis: A content‐quality and reliability analysis
Authors: Nishizaki Naoto , Hirano Daishi , Oishi Kimihiko , Shimizu Toshiaki 
Published: November 2021

AbstractBackgroundThis study aimed to evaluate the quality and reliability of Japanese YouTube videos pertaining to nocturnal enuresis (NE).MethodsIn this cross‐sectional study, we performed a YouTube search using the keyword “Ya‐nyou‐shou” (‘nocturnal enuresis’ in Japanese). We considered the first 200 videos listed based on the YouTube default option. Videos that were irrelevant, concerned personal experiences or adult NE, had non‐Japanese content, were advertisements, were duplicated, and those without audio were excluded. Video features and upload source were recorded. The Modified DISCERN, Journal of the American Medical Association (JAMA), and Global Quality Scale (GQS) scoring systems were used for analysis. Two independent pediatricians, specialists in nephrology and urology, completed the scoring. Correlation analysis was performed between video features and the three quality analysis scores.ResultsIn total, 72 videos were analyzed. The most common upload sources were physicians (40.3%) and non‐physician health personnel (40.3%). The median modified DISCERN, JAMA, and GQS scores for the videos were 1 (lowest: 0; highest: 4), 2 (lowest: 1; highest: 3), and 2 (lowest: 1; highest: 4), respectively. The highest scores for video power index (VPI) were for independent users (6.43 points) and physicians (3.05 points). There were positive correlations between the VPI and video length and modified DISCERN and GQS scores. No video presenter disclosed conflicts of interest.ConclusionsMost Japanese YouTube videos about NE were low quality. Healthcare experts should be encouraged to upload better quality content.
Interventions for Menière’s disease: an umbrella systematic review
Authors: van Esch Babette Fiebke , van der Zaag-Loonen Hester , Bruintjes Tjasse , Kuijpers Ton , van Benthem Peter Paul G 
Published: November 2021

ObjectivesTo systematically review the efficacy of interventions for Menière’s disease (MD) to report clinical implications of the results and to identify areas for future valuable research.MethodsIn line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Abstracts (PRISMA-A) guideline, a systematic online database search was conducted in which MEDLINE (PubMed), Embase (Ovid) and CENTRAL (Cochrane Library) were searched until May 2021 in order to search for the efficacy of treatment was analysed in a systematic review. Systematic reviews (SRs) on treatments for MD were screened for eligible interventions. From these SRs, we included placebo randomised controlled trials (RCTs). A separate search was conducted to identify RCTs on treatment modalities that were systematically reviewed yet published after the conduction of these SRs. The primary outcome was control of vertigo as defined by the American guideline as published in 1995. The PRISMA-A and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to appraise and evaluate the certainty of evidence.ResultsWe found five SRs from which 19 RCTs were extracted. Five RCTs were added by the separate search resulting in a total of 25 RCTs (n=1248) which evaluated the efficacy of betahistine dihydrochloride, intratympanic injections with gentamicin or steroids, endolymphatic sac surgery and pressure pulse therapy. Evidence on the efficacy of interventions for patients with MD is generally of low certainty. Betahistine (48 mg per day and 144 mg per day) and positive pressure therapy probably do not reduce MD symptoms when compared with placebo. Intratympanic injection with gentamicin or steroids, or treatment with endolymphatic surgery may reduce symptoms in MD when compared with placebo.ConclusionsA definite effective and well-tolerated therapy for MD has yet to be discovered and information on the natural course of disease is one of the biggest flaws in current research.PROSPERO registration numberCRD4201502424.
Development of a self-reported reflective tool on advanced access to support primary healthcare providers: study protocol of a mixed-method research design using an e-Delphi survey
Authors: Breton Mylaine , Gaboury Isabelle , Sasseville Maxime , Beaulieu Christine , Abou Malham Sabina , Hudon Catherine , Rodrigues Isabel , Maillet Lara , Duhoux Arnaud , Deville-Stoetzel Nadia , Haggerty Jeannie 
Published: November 2021

IntroductionTimely access is one of the cornerstones of strong primary healthcare (PHC). New models to increase timely access have emerged across the world, including advanced access (AA). Recently in Quebec, Canada, the AA model has spread widely across the province. The model has largely been implemented by PHC professionals with important variations; however, a tool to assess their practice improvement within AA is lacking. The general objective of this study is to develop a self-reported online reflective tool that will guide PHC professionals’ reflection on their individual AA practice and formulation of recommendations for improvement. Specific objectives are: (1) operationalisation of the pillars and subpillars of AA; (2) development of a self-reported questionnaire; and (3) evaluation of the psychometrics.Methods and analysisThe pillars composing Murray’s model of AA will first be reviewed in collaboration with PHC professional and stakeholders, patients and researchers in a face-to-face meeting, with the goal to establish consensus on the pillars and subpillars of AA. Leading from these definitions, items will be identified for evaluation through an e-Delphi consultation. Three rounds are planned in 2020–2021 with a group of 20–25 experts. A repository of recommendations on how to improve one’s AA practice will be populated based on the literature and enriched by our experts throughout the consultation. Median and measures of dispersions will be used to evaluate agreement. The resulting tool will then be evaluated by PHC professionals for psychometrics in 2021–2022.Ethics and disseminationThe Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre Scientific Research Committee approved the protocol, and the Research Ethics Board provided ethics approval (2020-441, CP 980475). Dissemination plan is a mix of community diffusion through and for our partners and to the scientific community including peer-reviewed publications and conference presentations.
Cerebral venous outflow profiles are associated with the first pass effect in endovascular thrombectomy
Authors: van Horn Noel , Heit Jeremy J , Kabiri Reza , Mader Marius M , Christensen Soren , Mlynash Michael , Broocks Gabriel , Meyer Lukas , Nawabi Jawed , Lansberg Maarten G , Albers Gregory W , Wintermark Max , Fiehler Jens , Faizy Tobias D 
Published: November 2021

BackgroundRecent studies found that favorable venous outflow (VO) profiles are associated with higher reperfusion rates after mechanical thrombectomy (MT) in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). Fewer retrieval attempts and first-pass revascularization during MT lead to better functional outcomes.ObjectiveTo examine the hypothesis that favorable VO profiles assessed on baseline CT angiography (CTA) images correlate with successful vessel reperfusion after the first retrieval attempt and fewer retrieval attempts.MethodsA multicenter retrospective cohort study of patients with AIS-LVO treated by MT. Baseline CTA was used to determine the cortical vein opacification score (COVES). Favorable VO was defined as COVES ≥3. Primary outcomes were successful with excellent vessel reperfusion status, defined as Thrombolysis in Cerebral Infarction (TICI) 2b/3 and 2c/3 after first retrieval attempt.Results617 patients were included in this study, of whom 205 (33.2%) had first pass reperfusion. In univariate analysis, ordinal COVES (p=0.011) values were significantly higher in patients with first pass than in those with non-first pass reperfusion, while the number of patients exhibiting favorable pial arterial collaterals using the Maas scale on CTA did not differ (p=0.243). In multivariable logistic regression analysis, higher COVES were independently associated with TICI 2b/3 (OR=1.25, 95% CI 1.1 to 1.42; p=0.001) and TICI 2c/3 (OR=1.2, 95% CI 1.04 to 1.36; p=0.011) reperfusion after one retrieval attempt, controlling for penumbra volume and time from symptom onset to vessel reperfusion.ConclusionsFavorable VO, classified as higher COVES, is independently associated with successful and excellent first pass reperfusion in patients with AIS-LVO treated by endovascular thrombectomy.
Identification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritis: a cluster analysis in the worldwide ASAS-PerSpA study
Authors: López-Medina Clementina , Chevret Sylvie , Molto Anna , Sieper Joachim , Duruöz Tuncay , Kiltz Uta , Elzorkany Bassel , Hajjaj-Hassouni Najia , Burgos-Vargas Ruben , Maldonado-Cocco José , Ziade Nelly , Gavali Meghna , Navarro-Compan Victoria , Luo Shue-Fen , Biglia Alessandro , Tae-Jong Kim , Kishimoto Mitsumasa , Pimentel-Santos Fernando M , Gu Jieruo , Muntean Laura , van Gaalen Floris A , Geher Pál , Magrey Marina , Ibáñez-Vodnizza Sebastián E , Bautista-Molano Wilson , Maksymowych Walter , Machado Pedro M , Landewé Robert , van der Heijde Desirée , Dougados Maxime 
Published: November 2021

ObjectiveTo identify clusters of peripheral involvement according to the specific location of peripheral manifestations (ie, arthritis, enthesitis and dactylitis) in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), and to evaluate whether these clusters correspond with the clinical diagnosis of a rheumatologist.MethodsCross-sectional study with 24 participating countries. Consecutive patients diagnosed by their rheumatologist as PsA, axial SpA or peripheral SpA were enrolled. Four different cluster analyses were conducted: one using information on the specific location from all the peripheral manifestations, and a cluster analysis for each peripheral manifestation, separately. Multiple correspondence analyses and k-means clustering methods were used. Distribution of peripheral manifestations and clinical characteristics were compared across the different clusters.ResultsThe different cluster analyses performed in the 4465 patients clearly distinguished a predominantly axial phenotype (cluster 1) and a predominantly peripheral phenotype (cluster 2). In the predominantly axial phenotype, hip involvement and lower limb large joint arthritis, heel enthesitis and lack of dactylitis were more prevalent. In the predominantly peripheral phenotype, different subgroups were distinguished based on the type and location of peripheral involvement: a predominantly involvement of upper versus lower limbs joints, a predominantly axial enthesitis versus peripheral enthesitis, and predominantly finger versus toe involvement in dactylitis. A poor agreement between the clusters and the rheumatologist‘s diagnosis as well as with the classification criteria was found.ConclusionThese results suggest the presence of two main phenotypes (predominantly axial and predominantly peripheral) based on the presence and location of the peripheral manifestations.
Pengaruh Bauran Pemasaran terhadap Keputusan Pembelian di Waserba Koperasi SESKO TNI Bandung
Authors: Dewi Wiwi Warsiati , Sudrartono Tiris , Sari Fitri Puspita 
Published: November 2021

Penelitian ini dilakukan untuk mengetahui bauran pemasaran di koperasi waserba sesko TNI Bandung. untuk mengetahui Keputusan pembelian, untuk mengetahui seberapa besar pengaruh Bauran Pemasaran terhadap keputusan pembelian, untuk mengetahui kendala yang ada dalam bauran Pemasaran dan untuk mengetahui upaya apa yang dilakukuan perusahaan dalam mengatasi kendala Bauran Pemasaran di Waserba Kopaerasi Sesko TNI Bandung.
Teknik Pengumpulan data yang digunakan adalah dengan memyebarkan Koesioner (angket) dengan 27 buah pertanyaan dan 82 responden dari sampel penelitian. Metode penelitian yang digunakan adalah metode kuantitatifs deskriptif, teknik analisis yang digunakan adalah teknik analisis Person Product Moment dengan pengolahan data menggunakan SPSS V 25.
Hasil peneltian menunjukkan bahwa adanya pengaruh bauran Pemasaran terhadap keputusan Pembelian di waserab Koperasi sesko TNI, Kota Bandung sebesar R 0,967 % yang terlihat pada R Sguare dan sisanya 6,5 % dipengaruhi oleh faktor lain yang tidak diteliti oleh penulis dengan tingkat Korelasi sedang.
Penulis menyimpulkan bahwa perusahan sudah cukup baik dalam melakukan pemasaran sebagai cara untuk dapat mempengaruhi keputusan pembelian terhadap produk perusahaan akan tetapi selama penulis meneliti adanya produk yang kurang variatif karena dibatasi oleh ruangan yang terbatas. Saran penulis diharapkan perusahaan lebih meluaskan tempat agar bisa menambah produk agar lebih variatif lagi.
Intraoperative Methadone Reduces Postoperative Opioid Requirements in Nuss Procedure for Pectus Excavatum
Authors: Froehling Nadia M. , Martin James A. , Miles M. Victoria P. , Wilson Andrew W. , Byers Brynn , LeMaster David , Salazar Óscar , Bhattacharya S. Dave , Smith Lisa A. 
Published: November 2021

Introduction Surgical correction of pectus excavatum by Nuss procedure, commonly referred to as minimally invasive repair of pectus excavatum (MIRPE), often results in significant postoperative pain. This study investigated whether adding intraoperative methadone would reduce the postoperative opioid requirement during admission for patients undergoing MIRPE. Methods A retrospective cohort chart review was conducted for 40 MIRPE patients between 2018 and 2020. Patients were stratified into 2 groups: those who received multimodal anesthesia (MM, n = 20) and those who received multimodal anesthesia with the addition of intraoperative methadone (MM + M, n = 20). Data collected included total opioid consumption during hospital stay (morphine milligram equivalents [MMEs]), hospital length of stay (LOS), pain scores, time to ambulation, and time to tolerating solid food. Results Addition of intraoperative methadone for patients undergoing MIRPE significantly reduced postoperative opioid requirements (MME/kg) during admission ( P = .007). On average, patients in the MM group received 1.61 ± .55 MME/kg while patients in the MM + M group received 1.16 ± .44 MME/kg. Hospital opioid (non-methadone) total was also significantly reduced between the MM (1.87 ± .54) and MM + M group (1.37 ± .46), P = .003. There was no significant difference in hospital opioid total MME/kg administered between the groups. There were no significant differences observed in hospital LOS, pain scores, time to ambulation, or time to toleration of solid food. Discussion Incorporating intraoperative methadone for patients undergoing MIRPE reduced postoperative opioid requirements and hospital opioid (non-methadone) totals without a significant change in pain scores. Patients undergoing the Nuss procedure may benefit from the administration of intraoperative methadone.
Percutaneous Cholecystostomy Tubes versus Medical Management for Acute Cholecystitis
Authors: Cook Madeline D. , Karim Saleema A. , Jensen Hanna K. , Bennett Judy L. , Burdine Lyle J. , Bhavaraju Avi , Sexton Kevin W. , Kalkwarf Kyle J. 
Published: November 2021

Background Cholecystitis is one of the most common infections treated surgically in the United States. Surgical risk is prohibitive in some patients, leading to alternative therapeutic strategies, including medical management (antibiotics) with or without percutaneous cholecystostomy tube (PCT) drainage. Materials and methods Using the Healthcare Cost and Utilization Project (HCUP) National Readmission Database (NRD), we performed a retrospective review to compare medically managed patients with or without PCT placement by evaluating 60-day readmissions rates, health care costs, and hospital length of stay (LOS). Both study groups were matched using the Elixhauser comorbidity index, age, and sex. Univariate and multivariate statistical analyses were performed using STATA. Results 776,766 patients were included in the analysis. The population receiving PCT placement was on average 16 years older (69.9 vs 53.6 years; P < .01), less likely to be female (40.7% vs 59.3%; P < .01), and had almost twice as many comorbidities (3.36 vs 1.81; P < .01) compared to the population receiving medical management. After matching our data to account for these incongruities, PCT patients were still 10.4 times more likely to be readmitted, had a 11.6% increase in the cost of care, and a 37.6% increase in LOS compared to those managed medically. Discussion Percutaneous cholecystostomy tube placement for cholecystitis is associated with a higher readmission rate, increased charges, and increased LOS compared to antibiotic therapy alone, even after correcting for age, sex, and comorbidities.
A Value-of-Information Framework for Personalizing the Timing of Surveillance Testing
Authors: Bansal Aasthaa , Heagerty Patrick J. , Inoue Lurdes Y. T. , Veenstra David L. , Wolock Charles J. , Basu Anirban 
Published: November 2021

Background Patient surveillance using repeated biomarker measurements presents an opportunity to detect and treat disease progression early. Frequent surveillance testing using biomarkers is recommended and routinely conducted in several diseases, including cancer and diabetes. However, frequent testing involves tradeoffs. Although surveillance tests provide information about current disease status, the complications and costs of frequent tests may not be justified for patients who are at low risk of progression. Predictions based on patients’ earlier biomarker values may be used to inform decision making; however, predictions are uncertain, leading to decision uncertainty. Methods We propose the Personalized Risk-Adaptive Surveillance (PRAISE) framework, a novel method for embedding predictions into a value-of-information (VOI) framework to account for the cost of uncertainty over time and determine the time point at which collection of biomarker data would be most valuable. The proposed sequential decision-making framework is innovative in that it leverages the patient’s longitudinal history, considers individual benefits and harms, and allows for dynamic tailoring of surveillance intervals by considering the uncertainty in current information and estimating the probability that new information may change treatment decisions, as well as the impact of this change on patient outcomes. Results When applied to data from cystic fibrosis patients, PRAISE lowers costs by allowing some patients to skip a visit, compared to an “always test” strategy. It does so without compromising expected survival, by recommending less frequent testing among those who are unlikely to be treated at the skipped time point. Conclusions A VOI-based approach to patient monitoring is feasible and could be applied to several diseases to develop more cost-effective and personalized strategies for ongoing patient care. Highlights In many patient-monitoring settings, the complications and costs of frequent tests are not justified for patients who are at low risk of disease progression. Predictions based on patient history may be used to individualize the timing of patient visits based on evolving risk. We propose Personalized Risk-Adaptive Surveillance (PRAISE), a novel method for personalizing the timing of surveillance testing, where prediction modeling projects the disease trajectory and a value-of-information (VOI)–based pragmatic decision-theoretic framework quantifies patient- and time-specific benefit-harm tradeoffs. A VOI-based approach to patient monitoring could be applied to several diseases to develop more personalized and cost-effective strategies for ongoing patient care.
Quality prescribing in early psychosis: key pharmacotherapy principles
Authors: Scott James G , McKeon Gemma , Malacova Eva , Curtis Jackie , Burgher Bjorn , Macmillan Iain , Thompson Andrew , Parker Stephen D 
Published: November 2021

Objective: To present a practical, easy-to-implement clinical framework designed to support evidence-based quality prescribing for people with early psychosis. Method: Identification and explanation of key principles relating to evidence-based pharmacotherapy for people with early psychosis. These were derived from the literature, practice guidelines and clinical experience. Results: Key principles include (1) medication choice informed by adverse effects; (2) metabolic monitoring at baseline and at regular intervals; (3) comprehensive and regular medication risk–benefit assessment and psychoeducation; (4) early consideration of long-acting injectable formulations (preferably driven by informed patient choice); (5) identification and treatment of comorbid mood disorders and (6) early consideration of clozapine when treatment refractory criteria are met. Conclusions: Current prescribing practices do not align with the well-established evidence for quality pharmacotherapy in early psychosis. Adopting evidence-based prescribing practices for people with early psychosis will improve outcomes.