bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors and Clinical Characteristics of Metabolic Bone Disease of Prematurity
Authors: Mutlu Mehmet , Aktürk-Acar Filiz , Kader Şebnem , Aslan Yakup , Karagüzel Gülay 
Published: May 2021

Objective The study aimed to analyze the risk factors and clinical features of metabolic bone disease of prematurity (MBDP) in premature infants compared with infants of similar gestational age and birth weight without MBDP.
Study Design This retrospective case–control study was performed by comparing 81 cases of MBDP with 63 controls to identify potential risk factors. Premature infants with a gestational age ≤33 weeks and birth weight <1,500 g were included. Medical records were examined in terms of maternal conditions, potential risk factors, and clinical characteristics.
Results Bone fractures and invasive ventilator dependence were the most common clinical features of MBDP. Duration of invasive ventilation and total mechanical ventilation days, necrotizing enterocolitis, corticosteroid use, anticonvulsive drug use, duration of dexamethasone and caffeine use, total parenteral nutrition, and length of hospitalization were significantly higher in neonates with MBDP (p < 0.05). Breastfed neonates and those receiving human milk fortifier had a lower incidence of MBDP than those premature formula or mixed feeding (p < 0.05). Anticonvulsive drug use (odds ratio: 2.935; 95% confidence interval: 1.265–6.810) was identified as a risk factor for MBDP at multiple regression analysis.
Conclusion Our results show that anticonvulsive drug use is a significant risk factor for the development of MBDP. If long-term use is not required, anticonvulsive drugs should be stopped as soon as possible. Further studies involving patients with MBDP are required to determine the risk factors and clinical features.
Key Points
Dorsal Spanning Plate for Perilunate Dislocations
Authors: Nguyen Duc M. , Boden Allison L. , Allen Megan K. , John Tamara , Knoll Greg M. , Dodds Seth D. 
Published: May 2021

Abstract
Purpose The purpose of this study was to compare radiographic outcomes in patients treated with the traditional method of open reduction, internal fixation (ORIF) and casting as compared with those treated with ORIF and dorsal spanning plate (DSP) fixation. We hypothesized that the application of a DSP to augment the repair of perilunate dislocations would maintain carpal stability while also allowing early loadbearing through the carpus.
Materials and Methods This is a retrospective radiographic review of patients with a perilunate dislocation, who were treated with ORIF and casting or ORIF with a dorsal spanning plate between 2012–2018. Scapholunate (SL) and lunotriquetral (LT) intervals were measured immediately after the index surgery and after scheduled hardware removal. A total of 28 patients met inclusion criteria, including 13 cases with traditional treatment and 15 cases with dorsal spanning plate fixation.
Results Comparison of the change in SL interval and LT interval between the 13 patients in the traditional treatment group and the 15 patients in the DSP group did not yield any clinically relevant variation after statistical analysis. Both groups demonstrated minimal change in the radiographic markers of carpal stability from postoperative radiographs obtained immediately after the index repair and after the removal of hardware.
Conclusion DSP fixation placed at the index surgery with early loadbearing for the treatment of perilunate dislocation is not inferior to the current mainstay of treatment consisting of cast immobilization without loadbearing and does not confer any increased carpal instability in comparison to ORIF and casting.
Lack of reliable post-fire recovery mechanisms makes the iconic Tasmanian conifer
Authors: Bliss Aimee , Prior Lynda D. , Bowman David M. J. S. 
Published: May 2021

Athrotaxis cupressoides is an iconic Tasmanian palaeoendemic conifer that is vulnerable to fire. A survey of three populations burnt by severe fire in 2016, conducted 1 year post-fire, found 33% of stems were still alive, with many surviving stems suffering some canopy scorch. We re-surveyed these populations to quantify delayed mortality, resprouting, and presence of juveniles, and to determine whether fire impacts can be reliably assessed after 1 year. We applied three measures of fire severity: canopy scorched, canopy consumed, and the minimum burnt twig diameter of neighbouring shrubs. We found overall stem survival in 2020 was 31%, and that 97% of stems that were dead 4 years post-fire had died within the first year. Our best predictor of stem mortality was percentage canopy scorched. Overall, 1.8% of burnt stems resprouted, but severely burnt stems did not resprout. Juveniles were present ~9.9% of burnt trees in 2017, and only 1.8% in 2020. We conclude that A. cupressoides stems are not unusually fire sensitive, but rather, that the species’ vulnerability to severe fire results from its lack of reliable recovery mechanisms. This study shows that fire-caused mortality can be reliably assessed 1 year post-fire, and possibly earlier. Interventions such as sowing seed or transplanting seedlings could be necessary to re-establish fire-killed populations.
A key requirement for synaptic Reelin signaling in ketamine-mediated behavioral and synaptic action
Authors: Kim Ji-Woon , Herz Joachim , Kavalali Ege T. , Monteggia Lisa M. 
Published: May 2021

Significance
Ketamine exerts rapid antidepressant action in some patients with treatment-resistant depression. This study demonstrates that Reelin, its receptor apolipoprotein E receptor 2 (Apoer2), and downstream signaling via Src family kinases are required for ketamine-mediated behavioral changes and associated synaptic plasticity in the CA1 hippocampal region. Our findings suggest that a permissive role of Reelin-dependent synaptic signaling in regulating the basal activity of N-methyl-D-aspartate receptors may be essential for ketamine’s antidepressant efficacy.
Emerging machine learning approaches to phenotyping cellular motility and morphodynamics
Authors: Choi Hee June , Wang Chuangqi , Pan Xiang , Jang Junbong , Cao Mengzhi , Brazzo Joseph A , Bae Yongho , Lee Kwonmoo 
Published: May 2021

Abstract
Cells respond heterogeneously to molecular and environmental perturbations. Phenotypic heterogeneity, wherein multiple phenotypes coexist in the same conditions, presents challenges when interpreting the observed heterogeneity. Advances in live cell microscopy allow researchers to acquire an unprecedented amount of live cell image data at high spatiotemporal resolutions. Phenotyping cellular dynamics, however, is a nontrivial task and requires machine learning (ML) approaches to discern phenotypic heterogeneity from live cell images. In recent years, ML has proven instrumental in biomedical research, allowing scientists to implement sophisticated computation in which computers learn and effectively perform specific analyses with minimal human instruction or intervention. In this review, we discuss how ML has been recently employed in the study of cell motility and morphodynamics to identify phenotypes from computer vision analysis. We focus on new approaches to extract and learn meaningful spatiotemporal features from complex live cell images for cellular and subcellular phenotyping.
On the estimate of music appraisal from surface EEG: a dynamic-network approach based on cross-sensor PAC measurements
Authors: Bakas Stylianos , Adamos Dimitrios A , Laskaris Nikolaos 
Published: May 2021

Abstract

Objective. The aesthetic evaluation of music is strongly dependent on the listener and reflects manifold brain processes that go well beyond the perception of incident sound. Being a high-level cognitive reaction, it is difficult to predict merely from the acoustic features of the audio signal and this poses serious challenges to contemporary music recommendation systems. We attempted to decode music appraisal from brain activity, recorded via wearable EEG, during music listening. Approach. To comply with the dynamic nature of music stimuli, cross-frequency coupling measurements were employed in a time-evolving manner to capture the evolving interactions between distinct brain-rhythms during music listening. Brain response to music was first represented as a continuous flow of functional couplings referring to both regional and inter-regional brain dynamics and then modelled as an ensemble of time-varying (sub)networks. Dynamic graph centrality measures were derived, next, as the final feature-engineering step and, lastly, a support-vector machine was trained to decode the subjective music appraisal. A carefully designed experimental paradigm provided the labeled brain signals. Main results. Using data from 20 subjects, dynamic programming to tailor the decoder to each subject individually and cross-validation, we demonstrated highly satisfactory performance (MAE= 0.948, R
2= 0.63) that can be attributed, mostly, to interactions of left frontal gamma rhythm. In addition, our music-appraisal decoder was also employed in a part of the DEAP dataset with similar success. Finally, even a generic version of the decoder (common for all subjects) was found to perform sufficiently. Significance. A novel brain signal decoding scheme was introduced and validated empirically on suitable experimental data. It requires simple operations and leaves room for real-time implementation. Both the code and the experimental data are publicly available.
First measurements with a NaI(Tl) crystal for the SABRE experiment
Authors: Mariani A. , Antonello M. , Barberio E. , Baroncelli T. , Benziger J. , Bignell L.J. , Bolognino I. , Calaprice F. , Copello S. , D’Angelo D. , D’Imperio G. , Dafinei I. , Di Carlo G. , Diemoz M. , Di Giacinto A. , Di Ludovico A. , Dix W. , Duffy A. R. , Hoppe E. , Ianni A. , Krishnan S. , Lane G.J. , Mahmood I. , McGee P. , Mould J. , Nuti F. , Orlandi D. , Pettinacci V. , Pietrofaccia L. , Rahatlou S. , Stuchbery A.E. , Suerfu B. , Tomei C. , Urquijo P. , Vignoli C. , Wada M. , Wallner A. , Williams A.G. , Zurowski M. 
Published: May 2021

Abstract
SABRE is a dark matter direct detection experiment aiming to measure the annual modulation of the dark matter interaction rate in NaI(Tl) crystals. SABRE focuses on the achievement of an ultra-low background rate operating high-purity NaI(Tl) crystals in a liquid scintillator veto for active background rejection. Moreover, twin experiments will be located in both Northern and Southern hemispheres (Italy and Australia) to disentangle any possible contribution from seasonal or site-related effects.
In this article the results of the first measurements with a NaI(Tl) crystal for the SABRE experiment performed at LNGS are presented.
Constructing a background model for DAMIC CCDs
Authors: Baxter Daniel 
Published: May 2021

Abstract
The DAMIC Collaboration uses fully-depleted silicon charge-coupled devices to search for low mass dark matter particles. We present a new analysis of backgrounds in the DAMIC at SNOLAB detector, which is used to construct a background model for an ongoing WIMP search analysis. The formation of this background model reveals new radioactive background components, the presence of which has since been experimentally confirmed. This background model additionally informs how best to proceed in meeting the lower background constraints of the DAMIC-M detector.
The SABRE Proof of Principle
Authors: Copello Simone , Antonello M. , Barberio E. , Baroncelli T. , Benziger J. , Bignell L.J. , Bolognino I. , Calaprice F. , Copello S. , D’Angelo D. , D’Imperio G. , Dafinei I. , Di Carlo G. , Diemoz M. , Di Giacinto A. , Di Ludovico A. , Dix W. , Duffy A. R. , Hoppe E. , Ianni A. , Krishnan S. , Lane G.J. , Mahmood I. , McGee P. , Mould J. , Nuti F. , Orlandi D. , Pettinacci V. , Pietrofaccia L. , Rahatlou S. , Stuchbery A.E. , Suerfu B. , Tomei C. , Urquijo P. , Vignoli C. , Wada M. , Wallner A. , Williams A.G. , Zurowski M. 
Published: May 2021

Abstract
SABRE is a dark matter direct detection experiment based on NaI(Tl) scintillating crystals. The primary goal of the experiment is to test the dark matter interpretation of the DAMA/LIBRA annual modulation signal. To reach its purpose, SABRE will operate an array of ultra-low background NaI(Tl) crystals within an active veto, based on liquid scintillator. Finally two twin detectors will be used, one in the northern hemisphere at Laboratori Nazionali del Gran Sasso, Italy (LNGS) and the other, first of its kind, in the southern hemisphere, in the Stawell Underground Physic Laboratory (SUPL). The collaboration has successfully developed a NaI(Tl) crystal with the impressive potassium content of about 4 ppb, according to the mass spectroscopy measurements. A value that, if confirmed, would be about 3 times lower than the DAMA/LIBRA crystals one. The first phase of the SABRE experiment, called SABRE Proof of Principle (PoP), aims to prove the achieved radiopurity by direct measurement of crystals at LNGS. This work reports the status of the PoP setup and the recent progresses on the development of low radioactivity NaI(Tl) crystals.
Search for dark matter in the form of axion-like particles and hidden photons in the XMASS detector
Authors: Sato Kazufumi 
Published: May 2021

Abstract
Axion-like Particles (ALPs) and Hidden Photons (HPs) are candidates of cold dark matter. These bosons are experimentally interesting because they are absorbed by materials through an interaction analogous to a photoelectric effect, transferring the energy equivalent to their rest mass to recoil electrons. XMASS is an experiment aiming at direct detection of dark matter, using single-phase liquid-xenon scintillator at the Kamioka Observatory in Japan. With its low background environment, the XMASS detector has a good sensitivity to the electron recoil signals from ALPs and HPs. Analyzing 800 live-days of XMASS data with 327 kg liquid xenon in the fiducial volume, we set the most stringent upper limits on the coupling constant gAe
of ALPs and the parameter for kinetic mixing α′/α of HPs in the mass range from 40 to 120 keV/c2.
Latest results of CRESST-III’s search for sub-GeV/c2 dark matter
Authors: Kluck H. , Abdelhameed A.H. , Angloher G. , Bauer P. , Bento A. , Bertoldo E. , Breier R. , Bucci C. , Canonica L. , D’Addabbo A. , Di Lorenzo S. , Erb A. , Feilitzsch F. v. , Ferreiro Iachellini N. , Fichtinger S. , Fuss A. , Gorla P. , Hauff D. , Ješkovský M. , Jochum J. , Kaizer J. , Kinast A. , Kraus H. , Langenkämper A. , Mancuso M. , Mokina V. , Mondragón E. , Olmi M. , Ortmann T. , Pagliarone C. , Palušová V. , Pattavina L. , Petricca F. , Potzel W. , Povinec P. , Pröbst F. , Reindl F. , Rothe J. , Schäffner K. , Schieck J. , Schipperges V. , Schmiedmayer D. , Schönert S. , Schwertner C. , Stahlberg M. , Stodolsky L. , Strandhagen C. , Strauss R. , Usherov I. , Willers M. , Zema V. , Zeman J. 
Published: May 2021

Abstract
The CRESST-III experiment searches for direct interactions of dark matter with ordinary matter. The main event signature would be a nuclear recoil inside one of the scintillating CaWO4 crystals. Operating the crystals as cryogenic calorimeters provides a phonon signal as measure of the deposited energy. The simultaneous readout of both signals is used to actively discriminate backgrounds. CRESST-III focuses on the sub-GeV/c2 mass region where the sensitivity is driven by the threshold. In the first data taking campaign of CRESST-III from 2016-2018 an unprecedented low threshold of 30.1 eV for nuclear recoils was obtained. In this contribution, we will report the status of the experiment and the latest results.
Directional Dark Matter Search with Nuclear Emulsion
Authors: Sato Osamu 
Published: May 2021

Abstract
Dark matter search by using nuclear emulsion, NEWSdm project is described here. The expected Dark matter signal is the recoiled nucleus track stopping within a few 100 nm in material. The short track length makes it difficult to detect. We have developed a fine grained nuclear emulsion to record the trajectory of the recoiled nucleus as several aligned silver grains by the nuclear emulsion. Track length is shorter than visible light wave length (400nm to 700nm). Therefore, dedicated techniques to overcome this limitation have been developed by the Collaboration. Carbon ion beams of relevant energies have been used to demonstrate the directional sensitivity with these techniques. Moreover, the scanning speed with automated microscopes is continuously increasing. WIMPs detection sensitivity with 10 kg nuclear emulsion target with a year exposure at LNGS will cover a large part of the DAMA signal region.
PICO-60 Results and PICO-40L Status
Authors: Krauss C. B. 
Published: May 2021

Abstract
PICO-60 and PICO-40L are bubble chambers for dark matter searches that are using C3F8 as active liquid. PICO-60 was operated successfully at SNOLAB until 2017 and
PICO-40L is now operating in the same location. PICO-40L follows a new detector concept that holds promise for future increases of sensitivity. We present the projected sensitivity of
PICO-40L for the WIMP-proton cross section.
MADMAX: A Dielectric Haloscope Experiment
Authors: Li Xiaoyue 
Published: May 2021

Abstract
Axions emerge naturally from the Peccei-Quinn mechanism, which addresses the absence of CP violation in the strong interaction, and they can make up the cold dark matter (CDM) in the universe. If PQ symmetry was broken after inflation, the CDM axion mass would likely be in the range of ˜ 26 μeV to ˜ 1 meV, which is yet to be explored experimentally. We present a new dielectric haloscope experiment dedicated to the direct detection of QCD axion dark matter in the mass range of 40 to 400 μeV – the MAgnetized Disc and Mirror Axion eXperiment (MADMAX). Multiple dielectric discs and a mirror are placed in a strong magnetic field to utilize the axion-induced coherent electromagnetic wave emitted from each disc surface and the resonance effect therein, such that the axion-induced signal can be boosted to a level detectable by state-of-the-art low noise amplifiers. We will discuss the motivation, design and sensitivity of MADMAX; ongoing R&D studies and the project roadmap will also be presented.
Results of direct dark matter detection with CDEX experiment at CJPL
Authors: Ma Hao , She Ze , Liu Zhongzhi , Yang Litao , Yue Qian , Zeng Zhi , Xue Tao 
Published: May 2021

Abstract
The China Dark Matter Experiment (CDEX), located at the China Jinping Underground Laboratory (CJPL) whose overburden is about 2400 m rock, aims at direct searches of light Weakly Interacting Massive Particles (WIMPs). A single-element 994-gram p-type point contact (PPC) germanium detector (CDEX-1B) runs inside a solid passive shielding system. To achieve lower background, a prototype 10 kg PPC germanium detector array (CDEX-10), consisting of three detector strings with three germanium crystals each, is directly immersed in the liquid nitrogen. With the energy threshold of 160 eV, the limits on WIMP-nucleus scattering are set by energy spectra and annual modulation analysis, respectively. Incorporating Migdal effect, the data of CDEX-1B are re-analyzed to search sub-GeV WIMPs. Finally, the future plan of CDEX experiment in CJPL-II is introduced.
Telescope Array: Latest Results and Expansion Plans
Authors: Bergman Douglas 
Published: May 2021

Abstract
We present the latest physics results from the Telescope Array Experiment, including an update to the ultra-high energy cosmic ray spectrum, new cosmic ray composition measurements in both hybrid and stereo modes, an update on the TA hotspot, and new measurements at lower energies using the NICHE array. We also give a status update on the TA×4 expansion currently underway.
Post-upgrade performance of GERDA Phase II
Authors: Wiesinger Christoph 
Published: May 2021

Abstract
Excellent spectroscopic performance, event topology information and outstanding radiopurity are unique properties of HPGe detectors that facilitate the search for 0vββ decay of 76Ge. A detection of this process would shed light onto physics beyond the standard model, as it would uncover the Majorana nature of neutrinos. The GERDA experiment employs an array of HPGe detectors, made from isotopically modified material, in an active liquid argon shield at the LNGS underground laboratory. The combination of an ultra-low background environment with active background rejection techniques allows the exploration of 0vββ decay half-lives beyond 1026 yr. No signal has been found in the first 58.9 kg⋅yr of Phase II data, from which the most stringent limit on 0vββ decay of 76Ge has been derived. In the course of an upgrade new HPGe detectors of novel type have been added to the array, increasing the total mass of enriched germanium to 44.2 kg. More than one year of data has been collected in this configuration. The first 24.9 kg⋅yr reveal encouraging performance for the ongoing 0vββ decay search.
LEGEND: The future of neutrinoless double-beta decay search with germanium detectors
Authors: Zsigmond Anna Julia 
Published: May 2021

Abstract
The observation of neutrinoless double beta (0vββ) decay would establish both the violation of lepton number conservation and the Majorana nature of the neutrino. It will also constrain the neutrino mass hierarchy and scale in the light-neutrino exchange mechanism. The current experiments using 76Ge for 0vββ decay search, the MAJORANA DEMONSTRATOR and GERDA, lead the field in both the ultra-low background and the energy resolution achieved. Building on their success, the LEGEND experiment will conduct an improved search with the goal of reaching a half-life sensitivity beyond 1028 years. In order to achieve this goal, the enriched Ge detector mass has to be increased up to tonne-scale and the backgrounds further reduced. LEGEND will pursue a phased approach with the first phase expected to start in 2021 with about 200 kg of 76Ge-enriched detectors operating at LNGS of INFN in Italy.
The CUORE cryostat
Authors: Nutini I. 
Published: May 2021

Abstract
The CUORE experiment (Cryogenic Underground Observatory for Rare Events) is a ton-scale detector, operating at a cryogenic temperature around 10 mK, searching for neutrinoless double-beta decay in 130Te and other rare events. The experiment cryogenic infrastructure, its subsystems and the cool-down procedure that allowed CUORE to obtained the first physics results will be presented.
Study on the contributions to the CUORE energy spectra
Authors: Dompè V 
Published: May 2021

Abstract
CUORE is a cryogenic experiment searching for the neutrinoless double beta decay of 130Te, and it is located at the underground Gran Sasso National Laboratories in the centre of Italy. With its 988 TeO2 crystals, operating at a base temperature of ~10 mK, CUORE is the first ton-scale and ultra-low background bolometric experiment ever realized for this purpose. There are many phenomena that contribute to the CUORE energy spectra, such as 2vββ decay, cosmic rays and materials and environmental radioactivity: disentangle these contributions is of fundamental importance for a correct interpretation of the results. In this poster, some relevant aspect of the CUORE background study is presented.
Study of neutrons associated with neutrino and anti-neutrino interactions on water at T2K
Authors: Akutsu Ryosuke 
Published: May 2021

Abstract
The study of neutron production associated with v interactions on water in an energy region from sub-GeV up to a few GeV is a key ingredient to improve the physics program of neutrino experiments based on water Cherenkov detectors. To this aim, a precise prediction of such neutron production by Monte Carlo (MC) simulation is essential. However, current predictions have large uncertainties related to the modeling of v interactions in the nuclear medium, hadronic final-state interactions (FSI) in nuclei, and secondary interactions (SI) in the detector medium. Therefore, it is worth evaluating the validity of the simulations with v beam. In this work, the status of a measurement of v and

v
¯

interactions on water in Tokai-to-Kamioka (T2K) experiment is described.