bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bullying at school and mental health problems among adolescents: a repeated cross-sectional study
Authors: Källmén Håkan , Hallgren Mats 
Published: December 2021

Abstract
Objective
To examine recent trends in bullying and mental health problems among adolescents and the association between them.

Method
A questionnaire measuring mental health problems, bullying at school, socio-economic status, and the school environment was distributed to all secondary school students aged 15 (school-year 9) and 18 (school-year 11) in Stockholm during 2014, 2018, and 2020 (n = 32,722). Associations between bullying and mental health problems were assessed using logistic regression analyses adjusting for relevant demographic, socio-economic, and school-related factors.

Results
The prevalence of bullying remained stable and was highest among girls in year 9; range = 4.9% to 16.9%. Mental health problems increased; range = + 1.2% (year 9 boys) to + 4.6% (year 11 girls) and were consistently higher among girls (17.2% in year 11, 2020). In adjusted models, having been bullied was detrimentally associated with mental health (OR = 2.57 [2.24–2.96]). Reports of mental health problems were four times higher among boys who had been bullied compared to those not bullied. The corresponding figure for girls was 2.4 times higher.

Conclusions
Exposure to bullying at school was associated with higher odds of mental health problems. Boys appear to be more vulnerable to the deleterious effects of bullying than girls.
Is the clinical pattern of pediatric celiac disease changing? A thirty-years real-life experience of an Italian center
Authors: Pedretti Melissa , Sbravati Francesca , Allegri Davide , Labriola Flavio , Lombardo Virginia , Spisni Enzo , Zarbo Chiara , Alvisi Patrizia 
Published: December 2021

Abstract
Objectives
Clinical presentation of pediatric celiac disease (CD) is heterogeneous and ever-evolving. Our aim is to highlight its changes throughout the years.

Methods
Data about clinical presentation of CD in children diagnosed between 1990 and 2020 at the CD Center of Maggiore Hospital, Bologna, were collected. Patients were stratified into groups based on the date [P1 (1990–2011), P2 (2012–2020)] and age [G1 (< 2 years), G2 (2–5), G3 (6–11), G4 (12–18)] at diagnosis, then investigated by comparing CD clinical presentation in different periods and ages.

Results
1081 children were selected. Mean age at diagnosis increases from 5.9 to 6.6 years from P1 to P2. Gastrointestinal Symptoms (GIs) are predominant, with a decline of diarrhea (47%VS30%) and an increase of constipation (4%VS19%) (p < 0.001). Among Extraintestinal symptoms (EIs) a decrease of anemia (76%VS43%, p = 0,001) is observed. Failure to Thrive (FTT) is stable throughout the years (p = 0.03), while screenings show a trend of increment (19%VS23%). GIs’ frequency decline from G1 to G4 (p = 0,001), with reduction of diarrhea (p < 0.001), and rise of recurrent abdominal pain (p = 0,02). EIs are more frequent at older ages, FTT in younger patients.

Conclusions
Changes in clinical presentation of CD have occurred in the last 30 years. We observe a reduction of severe and classic gastroenterologic symptoms and a rise of atypical ones, together with a growth of serological screenings and higher age at diagnosis. Awareness about CD clinical trends is crucial for a proper approach and early diagnosis.
Diagnostic challenges of an incidental finding: case report of definitely-congenital glioblastoma multiforme in a very preterm infant
Authors: Martini Silvia , Paoletti Vittoria , Maffei Monica , Zucchelli Mino , Locatelli Chiara , Fischer Maximilian , Fabbri Viscardo Paolo , Foschini Maria Pia , Tallini Giovanni , Corvaglia Luigi 
Published: December 2021

Abstract
Background
Congenital brain tumors are extremely rare in the neonatal population, and often associated with a poor prognosis. The diagnostic suspicion is often aroused at antenatal scans or postnatally, if clinical signs and symptoms of increased intracranial pressure become evident. We present a case of definitely congenital glioblastoma multiforme incidentally diagnosed in a preterm infant, aiming to raise clinical awareness on this condition and to highlight the challenges of the related diagnostic work-up.

Case presentation
This female infant was born at 31 weeks’ gestation after an uneventful pregnancy. No abnormalities were detected at antenatal ultrasound scans and genetic tests. Head circumference at birth was on the 25th centile. A routine brain ultrasound scan performed on day 1 revealed a large, inhomogeneous lesion in the right cerebral hemisphere, with contralateral midline shift, which was confirmed by brain magnetic resonance imaging (MRI). Eye fundus and routine blood exams, including platelets count, coagulation screening and C-reactive protein, were normal.
Given the high risk of complications, surgical biopsy of the lesion was temporarily hold and a daily sonographic follow-up was undertaken. Although head circumference growth was steady on the 25th centile, progressive changes of the lesion were detected by cranial ultrasound.
The repeat MRI scans showed a significant enlargement of the mass, with contralateral midline shift and signs of intralesional and intraventricular bleeding. In view of this worsening, surgical resection was performed. The histological examination of the lesion biopsy documented a GFAP+ highly cellular neoplasm, with no mutation on SMARCB1 gene. At the molecular analysis, mutations on IDH and H3F3A genes were absent, whereas MGMT promoter was unmethylated. The diagnosis was grade IV glioblastoma IDH wild-type.

Conclusions
Congenital glioblastoma multiforme is an extremely rare but highly aggressive neoplasm. Since intralesional biopsy is not often feasible in affected neonates, knowledge of the associated clinical and neuroradiological features is particularly important, as they can also add useful information on the neoplasm behavior. Specimens from open surgical resection allow to perform a definite histological analysis and an extended molecular characterization, with relevant prognostic implications.
Prevalence of germline TP53 mutation among early onset middle eastern breast cancer patients
Authors: Siraj Abdul Khalid , Masoodi Tariq , Bu Rong , Parvathareddy Sandeep Kumar , Iqbal Kaleem , Azam Saud , Al-Rasheed Maha , Ajarim Dahish , Tulbah Asma , Al-Dayel Fouad , Al-Kuraya Khawla Sami 
Published: December 2021

Abstract
Background
The data on prevalence and clinical relevance of TP53 germline mutations in early onset Middle-Eastern breast cancer (BC) is limited.

Methods
We determined TP53 germline mutations in a cohort of 464 early onset BC patients from Saudi Arabia using capture sequencing based next generation sequencing.

Results
Germline TP53 pathogenic mutations were found in 1.5% (7/464) of early onset Saudi BC patients. A total of six pathogenic missense mutations, one stop gain mutation and two variants of uncertain significance (VUS) were detected in our cohort. No TP53 pathogenic mutations were detected among 463 healthy controls. TP53 mutations carriers were significantly more likely to have bilateral breast cancer (p = 0.0008). At median follow-up of 41 months, TP53 mutations were an unfavorable factor for overall survival in univariate analysis. All the patients carrying TP53 mutations were negative for BRCA1 and BRCA2 mutations. Majority of patients (85.7%; 6/7) carrying TP53 mutation had no family history suggestive of Li-Fraumeni Syndrome (LFS) or personal history of multiple LFS related tumors. Only one patient had a positive family history suggestive of LFS.

Conclusions
TP53 germline mutation screening detects a clinically meaningful risk of early onset BC from this ethnicity and should be considered in all early onset BC regardless of the family history of cancer, especially in young patients that are negative for BRCA mutations.
Disablement in the Physically Active Scale Short Form-8: psychometric evaluation
Authors: Casanova Madeline P. , Nelson Megan C. , Pickering Michael A. , Larkins Lindsay W. , Appleby Karen M. , Grindley Emma J. , Baker Russell T. 
Published: December 2021

Abstract
Background
Patient-centered care and evidence-based practice (EBP) are core competencies for health care professionals. The importance of EBP has led to an increase in research involving clinical outcomes; current recommendations emphasize collecting patient focused measures, thus increasing the need for psychometrically sound patient reported outcome measures (PROMs) of health. Disablement has been identified as a valuable multi-dimensional construct for patient care. The Disablement in the Physically Active Scale Short Form-8 (DPA SF-8) has been proposed as a tool to be used in the physically active population that assesses a physical summary component of health and a quality of life component however, further analysis is necessary to ensure the instrument is psychometrically sound.

Methods
Confirmatory factor analyses (CFAs) were conducted on the DPA SF-8 at each time point to ensure factor structure. Reliability of the scale and internal consistency of the subscales were assessed, and a minimal detectable change (MDC) calculated. Additionally, a minimal clinically important difference (MCID) was also established, and invariance testing across three time points and groups was conducted.

Results
The CFAs at all three visits exceeded recommended model fit indices. The interclass correlation coefficient value (.924) calculated indicated excellent scale reliability and Cronbach’s alpha for subscales PHY and QOL were within recommend values. The MDC value calculated was 5.83 and the MCID for persistent injuries were 2 points and for acute injuries, 3 points. The DPA SF-8 was invariant across time and across subgroups.

Conclusions
The DPA SF-8 met CFA recommendations and criteria for multi-group and longitudinal invariance testing, which indicates the scale may be used to assess for differences between the groups or across time. Our overall analysis indicates the DPA SF-8 is a valid, reliable, and responsive instrument to assess patient improvement in the physically active population.
Reproducibility and research integrity: the role of scientists and institutions
Authors: Diaba-Nuhoho Patrick , Amponsah-Offeh Michael 
Published: December 2021

AbstractReproducibility and research integrity are essential tenets of every scientific study and discovery. They serve as proof that an established and documented work can be verified, repeated, and reproduced. New knowledge in the biomedical science is built on the shoulders of established and proven principles. Thus, scientists must be able to trust and build on the knowledge of their colleagues. Scientific innovation and research discoveries especially in the field of medicine has contributed to improving the lives of patients and increasing life expectancies. However, the growing concerns of failure to comply with good scientific principles has resulted in issues with research integrity and reproducibility. Poor reproducibility and integrity, therefore, may lead to ineffective interventions and applications. Here we comment on research reproducibility in basic medical and life sciences with regards to issues arising and outline the role of stakeholders such as research institutions and their employees in addressing this crisis.
Evidence of an active Cushing reflex in a preterm neonate with hyaline membrane disease: a case report
Authors: Rothberg Alan D. , Smith Johan , Lubbe Welma 
Published: December 2021

Abstract
Background
The Cushing reflex does not appear to have been described in preterm neonates. This case report shows the presence of an active Cushing reflex in a 32-week preterm neonate with hyaline membrane disease.

Case presentation
The 1.94 kg Caucasian infant was delivered by caesarean section following concerns about possible maternal infection and fetal compromise. Chest X-ray showed mild-to-moderate hyaline membrane disease and treatment was initiated with supplemental oxygen and nasal continuous positive airway pressure. It is probable that a pneumothorax occurred at 5–6 hours of age, with progression during the day. Interstitial air, pneumomediastinum, and tension pneumothorax were diagnosed on subsequent X-ray, and ultrasound of the brain showed a grade IV intraventricular hemorrhage. A review of the nurses’ recordings of heart rate, blood pressure, and respiratory rate showed a progressive increase in blood pressure accompanied by slowing of the heart rate and irregular respiration. These are features of the Cushing reflex that is elicited in response to raised intracranial pressure.

Conclusion
While well-described in older children and adults, in neonates the Cushing reflex has mainly been described in animal experiments and infants who have developed hydrocephalus. It is likely that in this case, the reflex was elicited as a result of a progressive increase in intracranial pressure due to the combination of elevated intrathoracic pressure, obstructed venous return from the brain, and concurrent intraventricular hemorrhage.
Magnetic nanoparticles in theranostics of malignant melanoma
Authors: Shevtsov Maxim , Kaesler Susanne , Posch Christian , Multhoff Gabriele , Biedermann Tilo 
Published: December 2021

AbstractMalignant melanoma is an aggressive tumor with a tendency to metastasize early and with an increasing incidence worldwide. Although in early stage, melanoma is well treatable by excision, the chances of cure and thus the survival rate decrease dramatically after metastatic spread. Conventional treatment options for advanced disease include surgical resection of metastases, chemotherapy, radiation, targeted therapy and immunotherapy. Today, targeted kinase inhibitors and immune checkpoint blockers have for the most part replaced less effective chemotherapies. Magnetic nanoparticles as novel agents for theranostic purposes have great potential in the treatment of metastatic melanoma. In the present review, we provide a brief overview of treatment options for malignant melanoma with different magnetic nanocarriers for theranostics. We also discuss current efforts of designing magnetic particles for combined, multimodal therapies (e.g., chemotherapy, immunotherapy) for malignant melanoma.
The cGAS–STING pathway: more than fighting against viruses and cancer
Authors: Bao Terigen , Liu Jia , Leng Jiyan , Cai Lu 
Published: December 2021

AbstractIn the classic Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can control the production of type I interferon and nuclear factor kappa-light-chain-enhancer of activated B cells to promote the activation of pro-inflammatory molecules, which are mainly induced during antiviral responses. However, with progress in this area of research, studies focused on autoimmune diseases and chronic inflammatory conditions that may be relevant to cGAS–STING pathways have been conducted. This review mainly highlights the functions of the cGAS–STING pathway in chronic inflammatory diseases. Importantly, the cGAS–STING pathway has a major impact on lipid metabolism. Different research groups have confirmed that the cGAS–STING pathway plays an important role in the chronic inflammatory status in various organs. However, this pathway has not been studied in depth in diabetes and diabetes-related complications. Current research on the cGAS–STING pathway has shown that the targeted therapy of diseases that may be caused by inflammation via the cGAS–STING pathway has promising outcomes.
Global solution to the compressible non-isothermal nematic liquid crystal equations with constant heat conductivity and vacuum
Authors: Mahmood Tariq , Sun Mei 
Published: December 2021

AbstractThis paper considers the initial-boundary value problem of the one-dimensional full compressible nematic liquid crystal flow problem. The initial density is allowed to touch vacuum, and the viscous and heat conductivity coefficients are kept to be positive constants. Global existence of strong solutions is established for any$H^{2}$H2initial data in the Lagrangian flow map coordinate, which holds for both vacuum and non-vacuum case. The key difficulty is caused by the lack of the positive lower bound of the density. To overcome such difficulty, it is observed that the ratio of$\frac{\rho _{0(y)}}{\rho (t,y)}$ρ0(y)ρ(t,y)is proportional to the time integral of the upper bound of temperature and vector director field, along the trajectory. Density weighted Sobolev type inequalities are constructed for both temperature and director field in terms of$\frac{\rho _{0(y)}}{\rho (t,y)}$ρ0(y)ρ(t,y)and small dependence on their dissipation estimates. Besides this, to deal with cross terms arising due to liquid crystal flow, higher order priori estimates are established by using effective viscous flux.
Differences between health technology assessment topics in high- and middle-income countries: a scoping review
Authors: Ghazinoory Sepehr , Majidi Basireh , Nasri Shohreh , Zandi Mohammad Ehsan , Farrokhi Hosein , Javedani Majid , Barzanouni Majid 
Published: December 2021

Abstract
Background
The Health Technology Assessment (HTA) has encountered different issues and challenges over the last two decades. The main purpose of this research is to review the issues and challenges in high- and middle-income countries through reviewing studies related to the HTA.

Methods
The HTA area literature of different countries was collected from 2009 to 2020 and analyzed using scoping review, based on Scopus and WoS databases.

Results
Given the fact that the HTA is practically done in high- and middle-income countries, the results of reviewing the studies and articles of countries reveal that high-income countries seek to increase the participation of stakeholders and enhance the transparency of processes, policy-making, and regulation of the HTA, as well as the systematization of various participant institutions in this area. Middle-income countries, on the other hand, are mostly involved in raising awareness, training and skill development of HTA-related staff, institutionalizing the concept of HTA, and allocating appropriate resources for effective and safe decision-making in their health system.

Conclusion
The problem of incoordination between stakeholders (participant institutions) in the HTA, and thereby, problems in decision-making were found in many of the studied reports and articles. Thus, one of the useful efforts to be made by different countries to maintain the integrity of this system would be the process of involving all members of this system and the formation of a healthy ecosystem in the HTA.
Movement and dispersal of a habitat specialist in human-dominated landscapes: a case study of the red panda
Authors: Bista Damber , Baxter Greg S. , Hudson Nicholas J. , Lama Sonam Tashi , Weerman Janno , Murray Peter John 
Published: December 2021

AbstractBackgroundHabitat specialists living in human-dominated landscapes are likely to be affected by habitat fragmentation and human disturbances more than generalists. But there is a paucity of information on their response to such factors. We examined the effect of these factors on movement patterns of red pandasAilurus fulgens, a habitat and diet specialist that inhabits the eastern Himalaya.MethodsWe equipped 10 red pandas (six females, four males) with GPS collars and monitored them from September 2019 to March 2020 in Ilam, eastern Nepal. We collected habitat and disturbance data over four seasons. We considered geophysical covariates, anthropogenic factors and habitat fragmentation metrics, and employed linear -mixed models and logistic regression to evaluate the effect of those variables on movement patterns.ResultsThe median daily distance travelled by red pandas was 756 m. Males travelled nearly 1.5 times further than females (605 m). Males and sub-adults travelled more in the mating season while females showed no seasonal variation for their daily distance coverage. Red pandas were relatively more active during dawn and morning than the rest of the day, and they exhibited seasonal variation in distance coverage on the diel cycle. Both males and females appeared to be more active in the cub-rearing season, yet males were more active in the dawn in the birthing season. Two sub-adult females dispersed an average of 21 km starting their dispersal with the onset of the new moon following the winter solstice. The single subadult male did not disperse. Red pandas avoided roads, small-habitat patches and large unsuitable areas between habitat patches. Where connected habitat with high forest cover was scarce the animals moved more directly than when habitat was abundant.ConclusionsOur study indicates that this habitat specialist is vulnerable to human disturbances and habitat fragmentation. Habitat restoration through improving functional connectivity may be necessary to secure the long-term conservation of specialist species in a human-dominated landscape. Regulation of human activities should go in parallel to minimize disturbances during biologically crucial life phases. We recommend habitat zonation to limit human activities and avoid disturbances, especially livestock herding and road construction in core areas.
Hand and wrist injuries among collegiate athletes vary with athlete division
Authors: Holoyda Kathleen A. , Donato Daniel P. , Magno-Padron David A. , Simpson Andrew M. , Agarwal Jayant P. 
Published: December 2021

Abstract
Background
The rates, severity and consequences of hand and wrist injuries sustained by National Collegiate Athletic Association athletes are not well characterized. This study describes the epidemiology of hand and wrist injuries among collegiate athletes competing in different divisions.

Methods
The National Collegiate Athletic Association Injury Surveillance Program (NCAA-ISP) was accessed from 2004 to 2015 for the following sports: baseball, basketball, football, ice hockey, lacrosse, soccer, wrestling, field hockey, gymnastics, softball and volleyball. The data were used to identify all hand and wrist injuries, the specific injury diagnosis, mean time loss of activity following injury, and need for surgery following injury. These were then stratified by gender. Descriptive statistics were performed to examine the association between sports, event type and division. Student's t test was used to calculate p-values for independent variables. Chi-Square test was used to calculate odds ratio. P < 0.05 was considered significant.

Results
103,098 hand and wrist injuries were reported in in the studied NCAA sports from 2004 to 2015. Male athletes sustained 72,423 injuries (6.01/10,000 athlete exposure) and female athletes sustained 30,675 injuries (4.13/10,000 athlete exposure). Division I athletes sustained significantly more injuries compared to divisions II and III. Overall, 3.78% of hand and wrist injuries required surgical intervention. A significantly higher percentage of division I athletes (both male and female) underwent surgical intervention compared to divisions II and III. The mean time lost due to hand and wrist injury was 7.14 days for all athletes. Division I athletes missed the fewest days due to injury at 6.29 days though this was not significant.

Conclusions
Hand and wrist injuries are common among collegiate athletes. Division I athletes sustain higher rates of injuries and higher surgical intervention rates, while tending to miss fewer days due to injury. Improved characterization of divisional differences in hand and wrist injuries can assist injury management and prevention.