bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Dynamics of Impulse Buying: Exploring the Impact of Price Discounts, Time Pressure, Easy of Transaction, and Price Perception on Shopee Live
Authors: Oning Amasuba Agnes , Apriani Ari 
Published: December 2024

This study investigates the factors influencing impulse buying behavior on Shopee Live, focusing on price discounts, time pressure, ease of transaction, and price perception. The findings reveal that price discounts significantly and positively affect impulse buying. Discounts enhance the perceived value of products, create a sense of urgency with time-limited offers, and utilize social influence by showcasing other buyers taking advantage of the deals. Time pressure also plays a crucial role, as it intensifies urgency, leading consumers to make quick, impulsive decisions. The interaction between sellers and consumers during live streaming further amplifies this effect. Conversely, ease of transaction does not significantly impact impulse buying. Although a smooth transaction process is appreciated, it does not independently drive impulsive purchases without the presence of other motivating factors. Additionally, positive price perception significantly boosts impulse buying, as consumers who view prices favorably are more likely to make spontaneous purchases. This study underscores the effectiveness of price discounts, time pressure, and positive price perception in enhancing impulse buying on Shopee Live, suggesting that sellers can optimize these factors to increase sales.
Perlindungan Hukum Terhadap Istri Atas Suami Yang Berpoligami Tanpa Persetujuan Istri dan Pengadilan
Authors: Raehany Vina Fadila Hasna 
Published: December 2024

Marriage in Indonesia based on the principle of monogamy, as written in Law Number 1 of 1974 concerning Marriage which emphasizes that a man can only have one wife, as well as a woman can only have one husband. However, there is an exception that a husband can have more than one wife on the condition that he has permission from the Court and is indeed desired by the parties concerned, and the act must have a consent from the first wife. There are still irregularities that occur in the practice of polygamy, one of them is a secret polygamous marriage carried out by a man with a woman apart from his wife without the consent of the legal wife and without the permission of the Religious Court, as happened in Decision Number 1106/Pdt.G/2024/PA.Cbn. The research method uses in this article is qualitative normative by referring to applicable regulations and doctrines with case study approach and the data collection is based on document studies. The result is that polygamous marriage carried out without the permission of the first wife and the Religious Court are invalid and null and void, which results in the second marriage being considered unprecedented. The legal protection for the first wife can be various, such as the application for annulment of the second marriage submitted by the first wife and also even if indications of fraud are found in the implementations of marriage to the Office of Religious Affairs, the first wife can report it and the parties involved can be subject to criminal sanctions.
Model Pemberdayaan Kader Lingkungan Adiwiyata dalam Pengelolaan Limbah Organik di SMPN 39 Semarang
Authors: Nadia Nadia , Cahyani Syifa Amalia Geanti , Nugroho Ariq Dwi Yulian , Nathalia Elsha Pipit , Maulana Muhammad Azra Fikri , Khoeriyah Fathul , Alfiana Devia Fitri , Ifada Hanif Syifa 
Published: December 2024

The main problem in the environment today is the large amount of organic waste produced from daily activities that is not managed properly, such as citrus fruit waste and fish waste. This can have a bad impact if not handled properly. This research aims to explain the process of implementing empowerment in organic waste management at SMP Negeri 39 Semarang, with a focus on making aromatherapy candles and organic liquid fertilizer. The Participatory Action Research (PAR) method is used to involve active participation of Adiwiyata Cadre students in research and action, enabling them to not only be research subjects but also actors in implementing community-based solutions. The research results show that the PAR method is able to provide students with an in-depth understanding of the importance of waste management. This process enriches students' knowledge of recycling and has a direct impact on the school environment, enabling them to face future environmental challenges.
Volatile-rich Sub-Neptunes as Hydrothermal Worlds: The Case of K2-18 b
Authors: Luu Cindy N. , Yu 余 Xinting 馨婷 , Glein Christopher R. , Innes Hamish , Aguichine Artyom , Krissansen-Totton Joshua , Moses Julianne I. , Tsai Shang-Min , Zhang Xi , Truong Ngoc , Fortney Jonathan J. 
Published: December 2024

Abstract
Temperate exoplanets between the sizes of Earth and Neptune, known as “sub-Neptunes,” have emerged as intriguing targets for astrobiology. It is unknown whether these planets resemble Earth-like terrestrial worlds with a habitable surface, Neptune-like giant planets with deep atmospheres and no habitable surface, or something exotic in between. Recent JWST transmission spectroscopy observations of the canonical sub-Neptune, K2-18 b, revealed ~1% CH4, ~1% CO2, and a nondetection of CO in the atmosphere. While previous studies proposed that the observed atmospheric composition could help constrain the lower atmosphere's conditions and determine the interior structure of sub-Neptunes like K2-18 b, the possible interactions between the atmosphere and a hot, supercritical water ocean at its base remain unexplored. In this work, we investigate whether a global supercritical water ocean, resembling a planetary-scale hydrothermal system, can explain these observations on K2-18 b–like sub-Neptunes through equilibrium aqueous geochemical calculations. We find that the observed atmospheric CH4/CO2 ratio implies a minimum ocean temperature of ~710 K, whereas the corresponding CO/CO2 ratio allows ocean temperatures up to ~1070 K. These results indicate that a global supercritical water ocean on K2-18 b is plausible. While life cannot survive in such an ocean, this work represents the first step toward understanding how a global supercritical water ocean may influence observable atmospheric characteristics on volatile-rich sub-Neptunes. Future observations with better-constrained CO and NH3 mixing ratios could further help distinguish between possible interior compositions of K2-18 b.
Service Utilization and Value at an Athletic Training Student Run Clinic for University Employees and Students
Authors: Wright Cynthia J. 
Published: December 2024

ABSTRACT

Context
Student-run health clinics (SRHC) are commonly utilized to provide clinical experiences to students in healthcare education programs as well as healthcare services to a target community. Recent reports on athletic training SRHCs (AT-SRHCs) with a client population of university students, employees and/or community members have reported positive patient outcomes and high patient satisfaction, however there is limited data about the treated conditions, services and value provided by AT-SRHC.

Objective
To track utilization of athletic training services at a free AT-SRHC.

Design
Retrospective chart review from September 2022-May 2024.

Setting
University-based AT-SRHC.

Patients
97 patients (52 males, 44 females, 1 not documented; age 32.6±13.7 years, range: 18-65 years old; 50 employees, 47 students).

Main Outcome Measures
Data were extracted from an electronic medical record and scheduling software. Variables extracted included patient demographics, appointment numbers, mechanism of injury, injured body part, days since injury, injury diagnosis, injury severity, and common procedural terminology (CPT) codes. Data were analyzed descriptively.

Results
Sixty-four percent (226/352) of available appointment sessions were reserved. The 3 most commonly injured body areas were the knee (n=26, 23.9%), shoulder (n=23, 21.1%), and thigh (n=13, 11.9%). The 3 most common diagnoses were sprains/strains (n=51, 46.8%), overuse conditions (e.g. epicondylitis, impingement, tendonitis; n=18, 16.5%), and nonspecific joint pain (n=22, 20.2%). The 3 most common CPT codes were for therapeutic exercise (n=136), athletic training evaluation (n=98), and manual therapy (n=78). Estimates for the total value of services range from $6,901 to $13,498 ($39.89-78.03 per session).

Conclusions
Services at an AT-SRHC were utilized by a small portion of the campus population during its first 2 years of operation. Data provides preliminary insight into AT-SRHC service utilization and value. Additional organizations may benefit from developing an AT-SRHC to provide access to affordable care and student clinical experiences.
Profile of patients with lung cancer at a tertiary care hospital in Nepal: A retrospective analysis
Authors: Yadav Birendra K , Thakur Alok , Pradhan Akash , Rizal Kushal , Rai Ujwal , Sharma Umesh K , Devkota Mukti , Gautam Akriti , Lama Manmath , Kumar Abhishek 
Published: December 2024

ABSTRACT

Background:
Cases of lung cancer are increasing in Nepal. Identifying histological types can influence prognosis and survival rates in different types of lung cancer.

Objectives:
The primary objective of this retrospective study was to provide a comprehensive clinical profile of patients with lung cancer. The secondary objective was to analyze the demographic characteristics of these patients.

Materials and Methods:
We analyzed the data for 192 patients diagnosed with lung cancer at Purbanchal Cancer Hospital, Birtamode, Nepal registered between January 2020 and December 2023. We categorized the cases into three categories: non-small-cell lung cancer (NSCLC), small-cell lung cancer, and others/not defined. NSCLC was further classified into squamous cell carcinoma and adenocarcinoma. A univariate analysis outlined patient attributes, histological classifications, stage of cancer, and the treatment received, while bivariate analysis assessed associations using Chi-square tests.

Results:
We included 192 patients in the study. Of them, 145 (75.5%) had NSCLC, with adenocarcinoma and squamous cell carcinoma being the most prevalent subtypes. Around 97% (186 patients) were diagnosed at an advanced stage. Only one-third of patients (62 patients, 32.3%) reported a history of smoking, and 90% (173 patients) were over 50 years old. Additionally, one fourth of the patients (43 patients, 22.4%) had hypertension. Chemotherapy and radiation therapy were the most used treatments.

Conclusion:
NSCLC is the most common histological type, with a higher proportion of patients being non-smokers. This emphasizes the need for further investigations into risk factors. Early detection and tailored interventions are critical for reducing the burden of lung cancer in Nepal.
Prevalence of cognitive impairment in patients receiving 5-fluoro-uracil containing chemotherapy: A systematic review and meta-analysis
Authors: D’souza Anita R , Chaudhari Jyoti , Pawar Akash , Ostwal Vikas , Jagdish Prathepa 
Published: December 2024

ABSTRACT
The burden of cognitive impairment in patients receiving chemotherapy is significant. In this systematic review, we seek to determine the prevalence of cognitive impairment in patients who received 5-fluoro-uracil (5-FU) containing chemotherapy. We searched literature using PubMed, ScienceDirect, Cumulative Index for Nursing and Allied Health Literature (CINAHL), and Wiley with different combinations of following keywords: (cognition OR cognitive function OR cognitive impairment OR cognitive dysfunction) AND (5-FU OR 5 fluorouracil OR chemotherapy). Full-text studies published in English involving humans as participants were included for systematic review. The reference lists of relevant studies were manually searched to identify additional studies by two authors/reviewers (AD and AP). A total of 115 records were identified through database searches, of which 74 remained after duplicates were removed. After title and abstract screening, 18 full-text articles were assessed for eligibility and were included in the final systematic review and 7 studies were included in the meta-analysis. For the purpose of discussion, we reviewed and included another 26 studies focusing on cognitive impairment by chemotherapy in patients with cancer and the methodological tools used in meta-analyses. The overall prevalence of cognitive impairment in patients who received 5-FU containing chemotherapy in studies included in meta-analysis was 32%. The majority of the studies involved breast cancer survivors as participants. Over one-third of the studies used the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) to assess cognitive function and cognitive impairment. The findings of this systematic review and meta-analysis highlight the impact of chemotherapy on cognitive functions in patients with cancer as well as cancer survivors, providing critical guidance for future research.
Clinical profile and outcomes of patients with endometrial cancer from Northwest India: A retrospective study
Authors: Philips Ashwin O , Kaur Tejinder , Garg Shirin , Sharma Ishu , Anand Mridul , Batta Nishant , Singh Harpreet 
Published: December 2024

ABSTRACT

Background:
Endometrial cancer is a significant health concern, but there is a lack of region-specific data on its clinical profile and outcomes in Northwest India. Recognizing the importance of early diagnosis and the evolving landscape of precision oncology, the study incorporated risk stratification based on established guidelines and updated staging.

Objectives:
The primary objective of the study was to determine the clinicopathological profile of patients with endometrial cancer. The secondary objectives were to estimate the survival outcomes, disease-free survival (DFS), and overall survival (OS) based on various staging protocols.

Materials and Methods:
We included patients with biopsy-confirmed carcinoma of the endometrium, managed at Mohan Dai Oswal Hospital, Ludhiana, Punjab from January 1, 2017 to August 31, 2022. Retrospective data were collected from electronic medical records and patient outpatient department files after ethics committee approval. The data were stratified according to the 2014 consensus guidelines of the European Society of Medical Oncology, the European Society of Gynecological Oncology, and the European Society for Radiotherapy and Oncology as well as the 2023 staging guidelines from the international federation of gynecology and obstetrics for analysis. Survival was calculated from histopathology confirmation to progression, death, or last follow-up. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) v22, with Kaplan-Meier for survival estimates, Cox regression for survival associations, and log-rank tests for group comparisons.

Results:
We included a total of 111 patients. The median age of the subjects was 64 years (range 37-88). Surgery was the primary treatment in 109 (98.7%). The 5-year OS and DFS rates were 85.6% and 75.7%, respectively, with high-risk patients showing worse outcomes (3-year OS: 75.2%; 4-year OS: 37.6%) compared to low/intermediate-risk patients (5-year OS: 100%, P < 0.001).

Conclusion:
This study highlights significant survival variations based on risk stratification in endometrial cancer, underscoring the need for tailored management approaches.
Empowering precision medicine in rural India by establishment of a molecular genetics laboratory in Bihar: A prospective observational study
Authors: Basu Moitri , Singh Ravikant , Bharadwaj Himanshu , Ray Shivangi , Choughule Anuradha , Prabhash Kumar , Dutt Amit , Kishore Kaushal , Singh Sanjay K , Sreekanthreddy Peddagangannagari , Gowda Pooja , Javle Vyomesh , Saha Prabir , Priyadharshini Bhumika , Saravanakumar Aarthy , Radhakrishnan Logesh , Rishi Kshitij , Goswami Hitesh , Veldore Vidya H 
Published: December 2024

ABSTRACT

Background:
In the era of precision oncology, molecular profiling and targeted therapies are integral to cancer management. However, accessibility remains a challenge in rural India.

Objectives:
The primary objective was to showcase the lab’s milestones using in-house next-generation sequencing (NGS)/qualitative real-time polymerase chain reaction (qRT-PCR) diagnostic data from patients with cancer. The secondary objective was to highlight the benefits of integrating NGS with precision medicine in rural India despite resource challenges.

Materials and Methods:
This prospective observational study was conducted at Homi Bhabha Cancer Hospital and Research Center, Muzaffarpur, Bihar, between November 2022 and December 2023. A 72-gene panel was validated as per National Accreditation Board for Testing and Calibration Laboratories (ISO15189/CAP/AMP/NABL) recommendations and implemented in routine clinical testing across multiple cancers. qRT-PCR was also established for detecting actionable mutations in epidermal growth factor receptor (EGFR exons 18-21) for lung cancer, NRAS/KRAS/HRAS/BRAF genes, and dihydropyrimidine dehydrogenase (DPYD) polymorphisms (DPYD*2A/*13/D949V/IVS10) for recommended cases.

Results:
In one year (November 2022 to December 2023), we performed 146 tests on Indian patients with cancer: 71% (n = 103) with NGS and the remainder with qRT-PCR. Among NGS cases, 71% (n = 73) involved lung cancer, while the rest covered various cancer types. Alterations in well-known driver genes were identified across the cancer types, and their frequencies were matching with the incidence reported in Indian literature.

Conclusion:
Operating high-end technology in a peripheral center grapple with unique challenges, often demanding resourcefulness and innovation. Nevertheless, our laboratory has made significant strides with every test performed in implementing precision medicine in a seemingly remote setting in rural India.
Impact of low-dose regorafenib on survival outcomes in patients with metastatic colorectal cancer: A retrospective study from a tertiary care center in South India
Authors: Lal Tejas Shivarthi , Kuriachan Sanitha , Kumar D Mahesh , Pavithran Keechilat , Babu Merin , Kartha Niveditha , Bari Abdul 
Published: December 2024

ABSTRACT

Background:
Metastatic colorectal cancer (mCRC) poses a significant health challenge, with limited treatment options and poor survival outcomes. Regorafenib, an oral multikinase inhibitor, is effective for patients with mCRC who have progressed after multiple chemotherapy lines. This study evaluates the impact of low-dose regorafenib on survival outcomes in patients at a tertiary care center in South India.

Objectives:
The primary objective was to determine overall survival outcomes associated with regorafenib in South Indian patients with prior colorectal cancer (CRC) treatment. Secondary objectives included assessing progression-free survival (PFS), safety profiles, and prognostic factors linked to regorafenib use.

Materials and Methods:
We analyzed patients treated with regorafenib from January 2015 to December 2023 in the Department of Medical Oncology at Amrita Institute of Medical Sciences, Kochi. Patient characteristics, including age, sex, primary tumor location, and metastatic sites, were recorded. PFS and overall survival (OS) were assessed, alongside treatment responses as per Response Evaluation Criteria for Solid Tumors (RECIST) version 1.1 criteria and adverse events (AEs) leading to treatment discontinuation.

Results:
We enrolled 81 patients, predominantly males (66.7%), with a mean age of 59.8 years. Distant metastasis at presentation occurred in 84% (n = 68) of patients. The median PFS was 9.2 months (95% CI, 8.05-10.35), while the mean OS was 39.2 months (95% CI, 33.3-45.1). The overall response rate was 13.5%, and AEs leading to discontinuation were noted in 16% (n = 13) of patients.

Conclusion:
Low-dose regorafenib demonstrated effectiveness, with favorable PFS and OS outcomes. Age and gender were identified as significant prognostic factors.
The incidence and outcome of postviral arthritis treated through whole system Ayurveda at a secondary care Ayurveda Arthritis Specialty Centre in North India
Authors: Rastogi Sanjeev , Maurya Kiran , Pandey Preeti , Kumar Sumit , Verma Ankita , Raveendranath Chinmayi 
Published: December 2024

Background:
Postviral arthritis is a common consequence of seasonal viral infections caused by chikungunya and dengue viruses. Presenting in its acute and chronic stages, arthritis often remains a stable complication of such infections in a large population. Despite its regular occurrence in epidemic proportions in India on a yearly basis, any substantial and dependable management is not available in conventional medicine to treat the primary condition and prevent joint-related complications. As a result, many among the affected population visit Ayurveda and other alternative system of medicine Practitioners in search of relief. Despite of finding a large input of such patients in Ayurveda clinics, serious observation has not been done in Ayurveda also to delineate the pattern and outcome of postviral arthritis treated at Ayurveda clinics.

Aims and Objectives:
Since a serious epidemiological and outcome observation is important as a proof of concept to initiate more serious studies in this area in the future, this observational study was done having focused upon these objectives at a secondary care Ayurveda arthritis treatment center in North India.

Materials and Methods:
Patients fulfilling the defined inclusion and exclusion criteria were registered and followed up for defined period of ayurvedic intervention. Subsequently outcomes were reported through gross statistical methods.

Result:
An average 56.8% improvement was reported by the study participants having received Ayurveda treatment for about 8 weeks. A substantial reduction in need of analgesics (needed only by <4% people post treatment) was also observed suggesting the beneficial effects of Ayurveda interventions in postviral arthritis.

Conclusion:
These preliminary observations suggest the conduction of serious clinical trials to see the effectiveness of Ayurveda interventions in postviral arthritis.
In vitro 5α-reductase inhibition by selected Ayurvedic herbs for androgenic disorders
Authors: Chakrabarty Anirban Kr , Banerjee Dipankar , Rai Rajiva Kumar , Katiyar Chandra Kant , Dubey Sunil Kumar 
Published: December 2024

Background:
Androgenic disorders such as androgenic alopecia is driven by elevated Dihydrotestosterone (DHT) levels, which are regulated by the enzyme 5α-reductase. The inhibition of 5α-reductase can thus be a therapeutic strategy for managing such disorders. This study explores the 5α-reductase inhibitory potential of selected Ayurvedic herbs, namely, Prunus dulcis Mill. (PD), Aloe barbadensis Mill. (AB), Bacopa monnieri (Linn.) Wettst. (BM), Glycyrrhiza glabra Linn. (GG), Emblica officinalis Gaertn. (EO), and Eclipta alba (L.) Hassk (EA).

Materials and Methods:
Hydroalcoholic and aqueous extracts of the selected herbs were prepared and tested for their efficacy in inhibiting 5α-reductase activity. Finasteride, a known 5α-reductase inhibitor, was kept as positive control. The enzymatic activity was measured by monitoring the consumption of NADPH, the cofactor required for the conversion of Testosterone (T) to DHT. A decrease in NADPH consumption indicates effective inhibition of 5α-reductase activity. The extracts were evaluated based on this biochemical method.

Results:
EA has shown the highest 5α-reductase inhibitory activity, followed by EO, PD, BM, GG, and AB in decreasing order.

Conclusion:
The study demonstrates that the selected Ayurvedic herbs possess significant 5α-reductase inhibitory properties, with EA showing the highest potential. These findings suggest that these herbs could be incorporated into hair care formulations and other therapeutic applications aimed at managing androgenic alopecia.