bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytotoxic Minor Piericidin Derivatives from the Actinomycete Strain Streptomyces psammoticus SCSIO NS126
Authors: Li Kunlong , Su Ziqi , Gao Yongli , Lin Xiuping , Pang Xiaoyan , Yang Bin , Tao Huaming , Luo Xiaowei , Liu Yonghong , Zhou Xuefeng 
Published: July 2021

The mangrove-sediment-derived actinomycete strain Streptomyces psammoticus SCSIO NS126 was found to have productive piericidin metabolites featuring anti-renal cell carcinoma activities. In this study, in order to explore more diverse piericidin derivatives, and therefore to discover superior anti-tumor lead compounds, the NS126 strain was further fermented at a 300-L scale under optimized fermentation conditions. As a result, eight new minor piericidin derivatives (piericidins L-R (1–7) and 11-demethyl-glucopiericidin A (8)) were obtained, along with glucopiericidin B (9). The new structures including absolute configurations were determined by spectroscopic methods coupled with experimental and calculated electronic circular dichroism. We also proposed plausible biosynthetic pathways for these unusual post-modified piericidins. Compounds 1 and 6 showed selective cytotoxic activities against OS-RC-2 cells, and 2–5 exhibited potent cytotoxicity against HL-60 cells, with IC50 values lower than 0.1 μM. The new piericidin glycoside 8 was cytotoxic against ACHN, HL-60 and K562, with IC50 values of 2.3, 1.3 and 5.5 μM, respectively. The ability to arrest the cell cycle and cell apoptosis effects induced by 1 and 6 in OS-RC-2 cells, 2 in HL-60 cells, and 8 in ACHN cells were then further investigated. This study enriched the structural diversity of piericidin derivatives and confirmed that piericidins deserve further investigations as promising anti-tumor agents.
Genetic Diversity of Leuconostoc mesenteroides Isolates from Traditional Montenegrin Brine Cheese
Authors: Ruppitsch Werner , Nisic Andjela , Hyden Patrick , Cabal Adriana , Sucher Jasmin , Stöger Anna , Allerberger Franz , Martinović Aleksandra 
Published: July 2021

In many dairy products, Leuconostoc spp. is a natural part of non-starter lactic acid bacteria (NSLAB) accounting for flavor development. However, data on the genomic diversity of Leuconostoc spp. isolates obtained from cheese are still scarce. The focus of this study was the genomic characterization of Leuconostoc spp. obtained from different traditional Montenegrin brine cheeses with the aim to explore their diversity and provide genetic information as a basis for the selection of strains for future cheese production. In 2019, sixteen Leuconostoc spp. isolates were obtained from white brine cheeses from nine different producers located in three municipalities in the northern region of Montenegro. All isolates were identified as Ln. mesenteroides. Classical multilocus sequence tying (MLST) and core genome (cg) MLST revealed a high diversity of the Montenegrin Ln. mesenteroides cheese isolates. All isolates carried genes of the bacteriocin biosynthetic gene clusters, eight out of 16 strains carried the citCDEFG operon, 14 carried butA, and all 16 isolates carried alsS and ilv, genes involved in forming important aromas and flavor compounds. Safety evaluation indicated that isolates carried no pathogenic factors and no virulence factors. In conclusion, Ln. mesenteroides isolates from Montenegrin traditional cheeses displayed a high genetic diversity and were unrelated to strains deposited in GenBank.
Anticancer Activity of Propolis and Its Compounds
Authors: Forma Ewa , Bryś Magdalena 
Published: July 2021

Propolis is a natural material that honey bees (Apis mellifera) produce from various botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and anti-inflammatory effects, have been known since antiquity. Cancer is one of the major burdens of disease worldwide, therefore, numerous studies are being conducted to develop new chemotherapeutic agents and treatments for cancer. Propolis is a rich source of biologically active compounds, which affect numerous signaling pathways regulating crucial cellular processes. The results of the latest research show that propolis can inhibit proliferation, angiogenesis, and metastasis of cancer cells and stimulate apoptosis. Moreover, it may influence the tumor microenvironment and multidrug resistance of cancers. This review briefly summarizes the molecular mechanisms of anticancer activity of propolis and its compounds and highlights the potential benefits of propolis to reduce the side effects of chemotherapy and radiotherapy.
Implementasi Strategi Pembelajaran Pendidikan Jasmani Kurikulum 2013 di SMAN 1 Jasinga
Authors: Esa Fitriana Agung , Iqbal Rahmat , Ratri Julianti Rekha 
Published: July 2021

Pendidikan merupakan suatu kebutuhan manusia yang berlangsung seumur hidup. Penelitian ini bertujuan untuk mengetahui kesiapan implementasi strategi pembelajaran Pendidikan jasmani berdasar kurikulum 2013. Penelitian ini menggunakan metode deskriptif kualitatif yang diintepretasikan dengan cara deskripsi, yang menyajikan data hasil penelitian berupa rangkaian kata-kata. Subjek dalam penelitian ini adalah guru penjasorkes dan kepala sekolah. Objek dalam penelitian ini adalah perencanaan, pelaksanaan pembelajaran, dan evaluasi pembelajaran penjas. Pengambilan data dilakukan secara interaktif, analisis pada model ini menggunakan model analisa Miles dan Huberman yang terdiri dari pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan dan verifikasi. Instrumen utama dalam penelitian ini menggunakan pedoman observasi. Dan instrumen pendukungnya adalah wawancara serta dokumentasi. Hasil penelitian menunjukan bahwa Implementasi Satrategi Pembelajaran Penjas Berdasarkan Kurikulum 2013 adalah baik, implementasi tersebut dapat dilihat berdasarkan hasil penelitian dari rencana pembelajaran adalah baik, pelaksanaan pembelajaran baik dan proses penilaianya juga baik. Dengan hasil tersebut dapat disimpulkan Implementasi Strategi Pembelajaran Penjas Berdasarkan Kurikulum 2013 adalah baik.
High-thermal-stability resistor formed from manganese nitride compound that exhibits the saturation state of the mean free path
Authors: Kino Hisashi , Fukushima Takafumi , Tanaka Tetsu 
Published: July 2021

Abstract
Antiperovskite manganese nitride compounds possess the saturation characteristics of the mean free path at an approximate room temperature. Therefore, such compounds show a flat resistance–temperature curve at an approximate room temperature. In this paper, we propose a manganese nitride resistor for high-thermal-stability systems. We fabricated and evaluated the micro/nanoscale manganese nitride compound resistors using the complementary metal-oxide-semiconductor-compatible process. The thermal coefficient of the fabricated manganese nitride compound resistor was as low as that of other near-zero temperature-coefficient of resistivity materials. These results indicate that manganese nitride compounds can achieve higher thermal stability.
Urgensi Manajemen Pendidikan Islamic Boarding School
Authors: Yusuf Maimun Muhammad , Mahdiyah Alifah , Nursafitri Dini 
Published: July 2021

Latar Belakang: Islamic boarding adalah salah satu sekolah Islam modern yang mempunyai asrama dan fasilitas yang lengkap untuk menunjang kemajuan pendidikan Islam, dan didalam sekolah ini sudah mempunyai pengajar yang berkualitas untuk memberikan kontribusi terbaiknya, dan Islamic boarding ini tidak hanya membahas tentang ukhrawi saja, melainkan tentang duniawi.
Tujuan: Memberikan pengetahuan dan memaparkan mengenai segala hal yang berkaitan dengan Islamic boarding school. Islamic boarding school sebagai wadah modern untuk pendidikan Islam.
Metode: Menggunakan metode studi literatur dari berbagai sumber seperti artikel jurnal, dan sebagainya
Hasil: Keberadaan konsep dan praktik manajemen pendidikan dewasa ini dirasakan perlu ada sentuhan baru. Hal demikian karena manajemen pendidikan merupakan ilmu terapan manajemen dalam dunia pendidikan. Sebagai ilmu yang berkembang dari dunia bisnis, norma dan etika keilmuan manajemen tidak dapat dipisahkan dari motif-motif ekonomi, hubungan manusiawi, dan aspek-aspek organisasi. Padahal dirasakan ada hal-hal fundamental pendidikan yang tidak bisa sekedar dengan pendekatan bisnis. Bahkan sebagaimana lazim pada keilmuan barat, persoalan moral dan etika seringkali terlepas dari pengembangan ilmu manajemen itu sendiri.
Kesimpulan: Dalam peningkatan mutu dan kualitas, diperlukan adanya manajemen yang baik guna mencapai tujuan tersebut Namun, tidak mengurangi eksistensi dari lembaga pendidikan itu sendiri. Sekolah Berasrama adalah alternatif terbaik buat para orang tua menyekolahkan anak mereka dalam kondisi apapun Mereka tidak hanya hidup untuk dirinya dan keluarganya tapi juga harus berbuat untuk bangsa dan Negara. Oleh sebab itu dukungan fasilitas terbaik, tenaga pengajar berkualitas, dan lingkungan yang kondusif harus didorong untuk mencapai cita-cita anak bangsa.
Pengaruh Brand Image, Service Quality dan Price terhadap Repurchase Intention pada Greenlight Bandung
Authors: Tamzil Adil Musty , Kuswanti Kuswanti , Urfah Mediana 
Published: July 2021

Keputusan minat beli berulang konsumen merupakan suatu Tindakan mengkonsumsi produk yang sama lebih dari satu kali ditentukan konsumen. Hal ini berdasarkan pada komitmen psikologis konsumen terhadap produk atau jasa yang disebabkan oleh pengalamannya setelah menggunakan produk tersebut, sehingga timbul keinginan untuk konsumsi ulang. Gagasan atau minat melakukan pembelian ulang muncul karena dipengaruhi oleh beberapa faktor tertentu, diantaranya yaitu “citra merek (brand image), kualitas pelayanan (Service Quality) dan Harga (Price)”. Tujuan dari penelitian adalah guna mengukur pengaruh Citra merek, kualitas pelayanan dan harga pada keinginan membeli ulang pada Greenlight Bandung. Metode penelitian yang dipergunakan merupakan metode deskriptif verifikatif. Sampel yang digunakan terdapat 115 responden. ”Pengolahan data mempergunakan analisis regresi linear berganda, koefisien determinasi, koefisien korelasi dan pengujian hipotesis.”Dari hasil analisis (uji t) didaptkan Brand Image, Service quality, dan Price baik secara parsial memiliki pengaruh sigifikan pada Repurchase intention. Berdasarkan hasil uji hipotesis (uji F) dan koefisien determinasi mempertunjukkan secara stimultan diperoleh pengaruh signifikan pada Brand image (X1), Service Quality (X2) dan Price (X3) terhadap Repurchase intention.
Analisis Setsuzokujoshi dalam Kalimat Bahasa Jepang
Authors: Sompotan Amelia G.Y 
Published: July 2021

Penelitian ini bertujuan untuk mencari persamaan dan perbedaan ketiga setsuzokujoshi tersebut dari segi penggunaan, struktur kalimat dan tingkat kesopanan dalam berbahasa Jepang. Metodologi yang digunakan yaitu metode kepustakaan, dimana penulis mengumpulkan berbagai definisi dan penjelasan mengenai fungsi dan struktur kalimat dari setsuzokujoshi te, kara dan node. Dalam penelitian deskriptif ini penulis mengumpulkan data dari buku ajar Minna No Nihongo I dan II Dari ketiga buku tersebut mencoba menggambarkan apa saja fungsi yang didapat dari hasil analisis contoh kalimat yang ditemukan, kemudian membuat kesimpulan atas data yang sudah dianalisis. Penelitian ini mengungkapkan bahwa fungsi kara (50%) sering digunakan dalam alasan yang menunjukan kemauan yang kuat seperti perintah, dasar dalam memberikan saran terhadap hal lain. Berdasarkan hasil analisis data, dapat disimpulkan bahwa setsuzokujoshi memiliki makna dan fungsi yang beragam. Kara bersifat subjektif, oleh karena itu dapat disambungkan dengan kalimat yang mengungkapkan pemikiran pribadi. fungsi kara sering digunakan dalam alasan yang menunjukan kemauan yang kuat seperti perintah, juga dalam memberikan saran terhadap hal lain. Setsuzokujoshi kara banyak dipengaruhi oleh pemikiran atau penilaian pribadi pembicara maka dikatakan kara bersifat subjektif dalam menyampaikan alasan. Sedangkan partikel de dan Setsuzokujoshi Node digunakan untuk mengutarakan sebab dari peristiwa atau situasi yang bersifat objektif tanpa dipengaruhi oleh pendapat atau pandangan pribadi node bersifat objektif, tidak bisa digunakan bersamaan dengan kalimat yang berupa keputusan atau kemauan pribadi.
O ensino de história diante dos discursos negacionistas e revisionistas no contexto da pandemia
Authors: Domiciano Derick Douglas , Krames Ilisabet Pradi , De Souza Marcel Oliveira , Campos Sabrina Silva 
Published: July 2021

O presente artigo reflete sobre a importância do ensino de História diante das proporções que a polarização político-ideológica vem assumindo no Brasil. A passos largos a polarização vem agravando ainda mais o cenário da pandemia causada pelo Coronavírus (SARS-CoV-2). Discursos negacionistas e revisionistas se propagam através de meios cibernéticos ancorados numa linguagem simplista e simplificada que evoca falsos discursos de verdade. Uma expressiva parte dos estudantes da Educação Básica hoje, estão conectados às redes sociais e recebem o conteúdo negacionista, revisionista diariamente. Diante desse cenário, a função do ensino de História precisa estar voltada à construção de espaços de sensibilidade e alteridade, contribuindo para uma sociedade humanizada que valoriza a vida, a ciência e a reflexão sistemática dos fatos.
PENGARUH FOTOAUTOTROFIK TERHADAP PERTUMBUHAN TUNAS KRISAN DALAM PROSES KULTUR IN VITRO SERTA PERBEDAAN STOMATA INVITRO DAN EXVITRO KRISAN
Authors: Saragih Siti Hartati Yusida , Rizal Khairul , Sitanggang Kamsia Dorliana 
Published: July 2021

Chrysanthemum (Chrysanthemum indicum L.) is an ornamental plant that is included in an important contribution in the ornamental plant business. Related to chrysanthemum buds grown in vitro in culture tubes or bottles with a tightly closed to avoid bacterial and fungal contamination and to protect the humidity of the culture environment. However, this tight cap often affects the composition of the gas in a jar or bottle, which inhibits plant growth. The purpose of this study was to study the effect of photoautotrophic on the growth of chrysanthemum buds in the in vitro culture process and the differences in invitro and exvitro chrysanthemum stomata. This research was conducted in March 2016 to May 2016 in the Microtechnical Laboratory, IPB University. Research results obtained from research on the position given to research conducted on the number of roots, the number of books and the number of shoots. The influence of the environment of exvitro also significantly affects the number of stomata, stomata width and stomata density. Keywords :ex vitro, in vitro, photoautotrophic
RELIGIOUS MODERATION CYBER: SEBUAH STRATEGI PENGARUSUTAMAAN MELALUI LITERASI MEDIA BARU
Authors: Futaqi Sauqi , Mashuri Saepudin 
Published: July 2021

This study aims to examine mainstreaming strategies through new media in the cyber world as an effort to find alternative formulation on enriching religious moderation’s life. The methodology used in this study is qualitative through intertextuality techniques. The findings show the results of data collected. All those three stages have emerged religious moderation cyber. As a result, it turns out that media provides convenience for religious people in accessing information and establishing relationships, but on the other hand the media is also often used as a channel to spread radical understanding, hoaxes, and spread hatred. Keywords: Religious Moderation; Mainstreaming Strategy; New Media Literacy
Accretion Flow Properties of GRS 1915+105 During Its θ Class Using AstroSat Data
Authors: Banerjee Anuvab , Bhattacharjee Ayan , Chatterjee Debjit , Debnath Dipak , Chakrabarti Sandip Kumar , Katoch Tilak , Antia H. M. 
Published: July 2021

Abstract
The Galactic microquasar GRS 1915+105 shows rich variability that is categorized into different classes. In this paper, we report the temporal and spectral analysis of GRS 1915+105 to study the properties of the accretion flow when the light curve shows θ class variability. For this purpose, we use the Large Area X-ray Proportional Counter data from the Target of Opportunity observations of India’s first multiwavelength astronomy satellite AstroSat. The θ class is marked by the recurrent appearance of U-shaped regions in the light curve, where the photon count rate first decreases rapidly and then increases slowly. For our analysis, we use U-shaped regions of the first two orbits (02345 and 02346) on 2016 March 4. In both cases, the dynamic power-density spectra (PDS) showed significant power at around 4–5 Hz, suggesting the presence of a low-frequency quasi-periodic oscillation (QPO) around that frequency interval. The QPO frequency is found to increase with time when the energy flux is also enhanced. From the evolution of the spectra, we determine the evolution of the accretion flow parameters in these two observations. Fitting the spectra with the transonic flow solution-based two-component advective flow (TCAF) model in the 4–25 keV energy band shows that the Keplerian disk accretion rate increases with the increase in radiation intensity, while the location of the centrifugal pressure-driven shock front decreases. In both these data, a gradual increment of power-law photon index with intensity is observed, suggesting the progressive softening of the source.
Brightness Fluctuation Spectra of Sun-like Stars. I. The Mid-frequency Continuum
Authors: Brown Timothy M. , García Rafael A. , Mathur Savita , Metcalfe Travis S. , Santos Ângela R. G. 
Published: July 2021

Abstract
We analyze space-based time-series photometry of Sun-like stars, mostly in the Pleiades, but also field stars and the Sun itself. We focus on timescales between roughly 1 hr and 1 day. In the corresponding frequency band these stars display brightness fluctuations with a decreasing power-law continuous spectrum. K2 and Kepler observations show that the rms flicker due to this mid-frequency continuum (MFC) can reach almost 1%, approaching the modulation amplitude from active regions. The MFC amplitude varies by a factor up to 40 among Pleiades members with similar T
eff, depending mainly on the stellar Rossby number Ro. For Ro ≤ 0.04, the mean amplitude is roughly constant at about 0.4%; at larger Ro the amplitude decreases rapidly, shrinking by about two orders of magnitude for Ro ≃ 1. Among stars, the MFC amplitude correlates poorly with that of modulation from rotating active regions. Among field stars observed for 3 yr by Kepler, the quarterly average modulation amplitudes from active regions are much more time variable than the quarterly MFC amplitudes. We argue that the process causing the MFC is largely magnetic in nature and that its power-law spectrum comes from magnetic processes distinct from the star’s global dynamo, with shorter timescales. By analogy with solar phenomena, we hypothesize that the MFC arises from a (sometimes energetic) variant of the solar magnetic network, perhaps combined with rotation-related changes in the morphology of supergranules.
A Simulation of Radius-frequency Mapping for PSR J1848-0123 with an Inverse Compton Scattering Model
Authors: Shang L. H. , Xu X. , Dang S. J. , Zhi Q. J. , Bai J. T. , Zhu R. H. , Lin Q. W. , Yang H. 
Published: July 2021

Abstract
The radio radiation mechanism is one of the open questions for pulsars. Multiband observations are very helpful to constrain pulsar radiation models. We observed PSR J1848-0123 at the 5 GHz band with the Shanghai Tianma 65 m radio telescope (TMRT). The 5 GHz observation together with the European Pulsar Network (EPN) and CSIRO ATNF Data Archives databases provides a broadband evolution property of the pulse profiles for this pulsar. We reprocessed these data sets to obtain the multiband pulse profiles. It was found that the pulse profile of PSR J1848-0123 narrows with increasing emission frequency. We separated the emission components of each pulse profile with a multi-Gaussian fitting method, and then calculated the beaming angle and emission radius of each component with the basic radiation geometry of pulsar. With the calculated beam angles and radiation radii, we simulated the radius-frequency mapping of this pulsar with an inverse Compton scatting model (ICS). It was found that the observed radio radiation could be generated in the core gap region above the polar cap of the pulsar. The beaming angle and emission radius versus frequency for PSR J1848-0123 can be explained well with the ICS model.
Innovative Delegation Application in Thai National Digital Identity Platform
Authors: Arunwatanamongkol Pensri , Nupairoj Natawut , Tanlamai Uthai 
Published: July 2021

<span lang="EN-US">The national digital identity platform is a robust scheme that enables individuals and entities to prove who they are to digitally access critical information or services. However, </span><span lang="EN-US">c</span><span lang="EN-US">urrent digital identity systems do not sufficiently consider delegation between entities from the viewpoint of dynamic authorizers and permissions. This study aims to understand the pain points and expectations of end-users and service providers in the Thai national digital identity platform, to design </span><span lang="EN-US">a dynamic delegation model </span><span lang="EN-US">and develop an innovative delegation application to test user acceptance. The research utilizes semi-structured interviews with 3 digital identity experts, two focus groups, one with 6 service providers, and the other one with 6 end-users. Based on results from the data analysis and conceptual prototype design, validated by experts, the proposed prototype is practical and suitable for developing a digital </span><span lang="EN-US">delegation </span><span lang="EN-US">mobile web application that is convenient, safe, secure, and reliable utilizing blockchain technology under the Thai national digital identity platform. </span><span lang="EN-US">The technology acceptance model</span><span lang="EN-US"> was used to test the application acceptance </span><span lang="EN-US">with </span><span lang="EN-US">42 participants</span><span lang="EN-US">. </span><span lang="EN-US">The result reveals that both person and businesses intend to adopt the digital delegation mobile web application.</span><span lang="EN-US"> </span><span lang="EN-US">Use cases of the application include users give their power to trusted entities and Government Agency to provide services to the citizens via the authorized delegatee.</span>
LOTFI A. ZADEH PHENOMENON IN THE DEVELOPMENT OF THE WORLD ARTIFICIAL INTELLIGENCE (AI) SYSTEM
Authors: GULİYEVA KHATIRA 
Published: July 2021

Lotfi A. Zadeh, whose 100th anniversary is celebrated all over the world in 2021, is a genius bestowed by the Azerbaijani people to the scientific world of thought.

Lotfi A. Zadeh the only phenomenon was chosen as a lifetime professor for great services in the field of artificial intelligence from the AI Institute.

The author's article titled "Lotfi A. Zadeh phenomenon in the development of the world artificial intelligence (Aİ) system" describes the life and rich scientific activity of the world-renowned Azerbaijani scientist Lotfi A. Zadeh.

İt is impossible to understand and imagine the methodology of artificial intelligence, which is currently relevant all over the world, without the philosophy of these sciences, including the theories of Lotfi A. Zade.

According to Google Scholar, as of February 2021, Lotfi A. Zadeh's work has been cited about 270,000 times in scholarly works, with the 1965 Fuzzy sets paper receiving more than 115,000 citations .

The author also sought to evaluate the methodological and practical relationship of Lotfi A.

Zadeh's idea and scientific navigation in an interdisciplinary direction.