bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Qualitative Study of Risk and Resilience in Young Adult Women With a History of Juvenile-onset Fibromyalgia
Authors: Daffin Morgan , Milder Mary Lynch , Gibler Robert C. , Murray Caitlin , Green Carly , Kashikar-Zuck Susmita 
Published: April 2021

Abstract
Background. Juvenile-onset Fibromyalgia (JFM) is a chronic pain condition characterized by widespread musculoskeletal pain, fatigue, sleep difficulties, mood concerns, and other associated symptoms. Although diagnosed in childhood, JFM often persists into adulthood can result in continued physical, social, and psychological impairment. The purpose of this qualitative study was to identify themes of risk and resilience for long-term outcomes among young adults diagnosed with JFM in childhood. Methods. The sample included 13 young adults (ages 26-34) who had been diagnosed with JFM in adolescence. Focus groups were used to elicit qualitative information about living with JFM and perceived challenges and buffering factors impacting their adjustment. Results. The majority of participants (80%, N=12) continued to meet criteria for fibromyalgia (FM). An iterative, thematic analysis revealed themes of resilience (e.g., greater acceptance, re-setting expectations, active coping, addressing mental health) and risk (e.g., lack of information, stigma, isolation, negative healthcare experiences). Conclusion. Results suggest the need for longer follow-up of youth with JFM as they transition to adulthood with multidisciplinary care and more attention to education about JFM and associated symptoms such as fatigue, as well as ongoing support for coping and mental health needs. A holistic approach to care during the transition years could be beneficial to minimize impact of JFM on long-term functioning.
Waste Food not Eat: Food Waste Treatment or Obesity - Selection of Sustainable Strategies for Dealing with Food Waste and Obesity
Authors: Smetana Sergiy , Profeta Adriano , Bhatia Anita , Heinz Volker 
Published: April 2021

Abstract
This theoretical model-based study is aimed to answer an applied but system-related question, relevant to multiple current studies and general audience: Is it better for human health and the environment to consume extra portion of food or throw it in the garbage (for further treatment)? The question has deep conceptual roots and requires a holistic approach to assessing a few complex systems: food production, food waste treatment and medical treatment activities. According to estimations, there are around 3.05-7.2 Mtonnes of avoidable food waste generated by German consumers at the household level. Simultaneously, high levels of food overconsumption are also observed at the household level. Thus, more than half of all Germans are overweight and obese and a high share of them require additional medical treatment resources. The study compared the environmental impact of treating potentially avoidable food waste with current waste management system in Germany to the hypothetical scenario of consuming such amount of food by the existing population. The results indicated that current waste management system is more beneficial for the environment than consuming excessive food by German population and requesting related medical services in categories of global warming potential (0.128 versus 0.6-2.4 Mtonnes CO 2 eq.), energy demand (-21 versus 16-66 PJ) and water footprint (-1607 versus 13.2-53 million m 3).However, land use impact allocated to other healthcare due to food consumed by humans is 13-80% lower than current waste treatment. Another danger of consuming excessive food relates to accumulated risks and further increased demand for health services. Following years would worsen the situation, making a choice for “food waste avoided” diet unfeasible. The results received do not allow for a simple Sergiy Smetana 1 et al. answer on selecting more sustainable strategies of dealing with an excessive amount of food in every specific case. However, they allow to indicate preferable conditions for dealing with excessive food in model conditions, which account for health status of household members or group of people (population), nutrient density and amount of food, and time frame. Time factor is one of the key factors defining preferences for food-wasting or consumption.
Solar Forcing of Early Holocene Droughts on the Yucatán Peninsula
Authors: Warken Sophie , Schorndorf Nils , Stinnesbeck Wolfgang , Hennhoefer Dominik , Stinnesbeck Sarah , Förstel Julius , Steidle Simon , Olguin Jerónimo Avilés , Frank Norbert 
Published: April 2021

Abstract
A speleothem record from the north-eastern Yucatán peninsula (Mexico) provides new insights into the tropical hydro-climate of the Americas between 11,040 and 9,520 a BP on up to sub-decadal scale. Despite the complex atmospheric reorganization during the end of the last deglaciation, the dominant internal leading modes of precipitation variability during the late Holocene were also active during the time of record. While multi-decadal variations were not persistent, decadal- and centennial-scale ENSO activity driven by solar forcing dominated Mesoamerican precipitation variability. Freshwater fluxes from the remnant Laurentide ice sheet into the Gulf of Mexico and the North Atlantic have additionally modulated the regional evaporation/precipitation balance. In particular, this study underlines the importance of solar activity on tropical and subtropical climate variability through forcing of the tropical Pacific, providing a plausible scenario for observed recurrent droughts on the decadal scale throughout the Holocene.
Single Cell Raman Spectroscopy to Identify Different Stages of Proliferating Human Hepatocytes for Cell Therapy
Authors: Ma Chen , Zhang Ludi , He Ting , Cao Huiying , Ma Chenhui , Yang Jiale , Huang Ruimin , Pan Guoyu 
Published: April 2021

Abstract
Background: Cell therapy provides hope for treatment of advanced liver failure. Proliferating human hepatocytes (ProliHHs) were derived from primary human hepatocytes (PHH) and as potential alternative for cell therapy in liver diseases. Due to the continuous decline of mature hepatic genes and increase of progenitor like genes during ProliHHs expanding, it is challenge to monitor the critical changes of the whole process. Raman microspectroscopy is a noninvasive, label free analytical technique with high sensitivity capacity. In this study, we evaluated the potential and feasibility to identify ProliHHs from PHH with Raman spectroscopy.Methods: Raman spectra were collected at least 600 single spectrum for PHH and ProliHHs at different stages (Passage 1 to Passage 4). Linear discriminant analysis and a two-layer machine learning model were used to analyze the Raman spectroscopy data. Significant differences in Raman bands were validated by the associated conventional kits.Results: Linear discriminant analysis successfully classified ProliHHs at different stages and PHH. A two-layer machine learning model was established and the overall accuracy was at 84.6%. Significant differences in Raman bands have been found within different ProliHHs cell groups, especially changes at 1003 cm-1, 1206 cm-1 and 1300 cm-1. These changes were linked with reactive oxygen species, hydroxyproline and triglyceride levels in ProliHHs, and the hypothesis were consistent with the corresponding assay results. Conclusions: In brief, Raman spectroscopy was successfully employed to identify different stages of ProliHHs during dedifferentiation process. The approach can simultaneously trace multiple changes of cellular components from somatic cells to progenitor cells.
Lymph node yield during surgery after neoadjuvant therapy compared to surgery without neoadjuvant therapy in patients with esophageal, gastric, pancreatic, or rectal carcinoma: systematic review and meta-analysis
Authors: Ronellenfitsch Ulrich , Maximov Nika , Friedrichs Juliane , Kleeff Jörg 
Published: April 2021

Abstract
Background: The lymph node yield is an important surrogate parameter for assessing the oncological radicality of the resection of gastrointestinal carcinomas and a prognostic factor in these diseases. It remains unclear if and to what extent neoadjuvant chemotherapy, radiotherapy or chemoradiotherapy, which have become established treatments for carcinoma of the esophagus, stomach, and rectum and are increasingly used in pancreatic carcinoma, affect the lymph node yield. This systematic review and meta-analysis intents to summarize the available evidence on the topic.Methods: Studies comparing oncological resection of esophageal, stomach, pancreatic and rectal carcinoma with and without prior neoadjuvant therapy are eligible for inclusion regardless of study design. Publications will be identified with a defined search strategy in the electronic databases PubMed and Cochrane Library. The primary endpoint of the analysis is the number of lymph nodes identified in the resected specimen. Secondary endpoints include number of harvested metastatic lymph nodes, operation time, postoperative complications, pTNM staging, and overall and recurrence-free survival time. Using suitable statistical methods, the endpoints between patients with and without neoadjuvant therapy as well as in defined subgroups (neoadjuvant chemotherapy, neoadjuvant radiotherapy, neoadjuvant chemoradiotherapy, and esophageal, gastric, pancreatic, and rectal cancer) will be compared Discussion: This systematic review with meta-analysis is conducted with the aim of summarizing the available evidence regarding the oncological surrogate marker lymph node yield in patients with gastrointestinal carcinomas undergoing surgery after neoadjuvant treatment compared to those operated without neoadjuvant therapy.Systematic review registration: This systematic review has been submitted for registration at PROSPERO, ID: 218459.
MicroRNA Profiling of Plasma Extracellular Vesicles in Bicuspid Aortopathy
Authors: Zhu Shichao , Zhao Yun , Abudupataer Mieradilijiang , Zhang Hongqiang , Liu Dingqian , Ma Wenrui , Bu Shuolei , Luo Shaman , Yan Shiqiang , Sun Yongxin , Li Jun , Lai Hao , Wang Chunsheng , Zhu Kai 
Published: April 2021

Abstract
Background: Bicuspid aortic valve (BAV) is the most common congenital cardiovascular disease and highly associated with ascending aortic dilation, i.e., bicuspid aortopathy. When the maximal aortic diameter achieves a critical threshold, prophylactic surgical intervention is recommended to prevent potential aortic dissection or rupture. However, the aortic diameter threshold cannot precisely predict the aortopathy progression and should be supplemented by more non-size parameters to provide more information for surgical decision. There is an urgent need for identification of a stable prognostic biomarker for BAV patients with increased risk of aortopathy progression. Methods and Results: In total, 24 patients with BAV and 6 healthy volunteers with tricuspid aortic valve (TAV) were involved in this study. Quantitative proteomics were employed to identify protein expressions in plasma. Sorted by the ratio of transforming growth factor-β1 (TGF-β1) to soluble endoglin (sENG) (T/E), which has been recognized as a plasma protein biomarker for aortopathy progression, BAV patients were divided into two groups with high (≥ 0.5, n = 6) or low (T/E < 0.5, n = 18) ratio of T/E. The mcroiRNA (miR) profiling of plasma extracellular vesicles (EVs) was performed using small RNA sequencing. The results revealed that low ratio of EV-miR324 to miR145 (≤ 0.1) was closely correlated to high ratio of T/E.Conclusions: The ratio of plasma miR324 to miR145 from EVs may identify the risk of progression of BAV aortopathy.
Calculation method for daily water intake components using doubly labeled water
Authors: Yamada Yosuke , Watanabe Daiki , Sagayama Hiroyuki , Itoi Aya , Yoshida Tsukasa , Watanabe Yuya , Nanri Hinako , Yoshimura Eiichi , Pontzer Herman , Luke Amy , Kimura Misaka , Schoeller Dale , Miyachi Motohiko , Speakman John 
Published: April 2021

Abstract
Daily water intake (DWI) is essential for survival in humans; however, accurate assessment of DWI from drinks and beverages (Wdrinks) or food moisture (Wfoods) is difficult as it depends on self-reported intakes that are prone to inaccuracy. Here, we established an objective method to assess DWI components using doubly labeled water (DLW). Deuterium and H218O were orally administered, and the dilution space and elimination rate of 2H and 18O were measured. DWI was calculated from the deuterium turnover corrected for metabolic water production and insensible water absorption from humidity. Wfoods was estimated using dietary record (Wfoods-DR) or calculated from the total energy expenditure assessed by DLW (Wfoods-DLW). The current results underscore Wfoods-DR underestimation using self-reported dietary assessments, which underestimates food intake. This study proposes novel methods for calculating each DWI component using DLW.
Geosocial Networking Dating App Usage and Risky Sexual Behavior in Young Adults Attending a Music Festival: Cross-sectional Questionnaire Study
Authors: Garga Shirali , Thomas Meryl , Bhatia Ashneet , Sullivan Aidan , John-Leader Franklin , Pit Sabrina 
Published: April 2021

Background
Despite the prevalent use of geosocial networking dating apps (GNDAs), there is limited research on their impact on sexual health outcomes among young music festivals attendees.

Objective
This study aims to explore the use of GNDAs and risky sexual behaviors of young adults attending a music festival.

Methods
The music festival attendees (N=862) completed a cross-sectional questionnaire study encompassing demographics, dating app use, and risky sexual behaviors in the past year. Associations between these variables were estimated using bivariate and multivariate logistic regression analyses.

Results
Of the respondents, 51.9% (448/862) had used GNDAs in the previous year. Compared with people who had 1 partner, people who had 2-5 sexual partners in the previous year had almost 7 times the odds of using dating apps (odds ratio [OR] 6.581, 95% CI 4.643-9.328) and those who had more than 5 partners had 14 times the odds of using dating apps (OR 14.294, 95% CI 8.92-22.906). Condom users were more likely to be app users (P<.001), as were those who relied on emergency Plan B (P=.002), but people using hormonal contraception were less likely to use dating apps (P=.004). After adjusting for sexual orientation and relationship status, those having casual sex had 3.096 (95% CI 2.225-4.307; P<.001) times the odds of using dating apps and those having multiple sexual partners had 3.943 (95% CI 2.782-5.588; P<.001) times the odds of using dating apps. Similarly, after adjusting for sexual orientation, relationship status, and number of sexual partners, people who had no discussions before having sex about sexually transmitted infections (STIs) or boundaries were more likely to use dating apps (OR 1.755, 95% CI 1.232-2.500; P=.002). Those who perceived the risk of having sex without contraception to be very high had 2.486 (95% CI 2.213-5.096; P=.01) times the odds of using dating apps than those who perceived no risk. Compared with those who perceived no risk, people who thought that the risk of having multiple sexual partners was low to high had 1.871 (95% CI 1.024-3.418; P=.04) times the odds of using dating apps. A significant number of app users (389/440, 88.4%) indicated that GNDAs should promote safe sex.

Conclusions
This study identified that festival goers engaging in certain high-risk sexual behaviors, including casual sex, having multiple sexual partners, and having sex without discussion about STI status and boundaries, are more likely to use dating apps. Festival goers who perceived sex without any form of contraception, having sex while drunk, and having multiple sexual partners as risky were more likely to be app users. Policy makers and GNDA developers should acknowledge the vulnerability of their users to adverse sexual health outcomes and use GNDAs as a platform to promote risk-reduction practices.
Public Interest in Immunity and the Justification for Intervention in the Early Stages of the COVID-19 Pandemic: Analysis of Google Trends Data
Authors: Lee Jinhee , Kwan Yunna , Lee Jun Young , Shin Jae Il , Lee Keum Hwa , Hong Sung Hwi , Han Young Joo , Kronbichler Andreas , Smith Lee , Koyanagi Ai , Jacob Louis , Choi SungWon , Ghayda Ramy Abou , Park Myung-Bae 
Published: April 2021

Background
The use of social big data is an important emerging concern in public health. Internet search volumes are useful data that can sensitively detect trends of the public's attention during a pandemic outbreak situation.

Objective
Our study aimed to analyze the public’s interest in COVID-19 proliferation, identify the correlation between the proliferation of COVID-19 and interest in immunity and products that have been reported to confer an enhancement of immunity, and suggest measures for interventions that should be implemented from a health and medical point of view.

Methods
To assess the level of public interest in infectious diseases during the initial days of the COVID-19 outbreak, we extracted Google search data from January 20, 2020, onward and compared them to data from March 15, 2020, which was approximately 2 months after the COVID-19 outbreak began. In order to determine whether the public became interested in the immune system, we selected coronavirus, immune, and vitamin as our final search terms.

Results
The increase in the cumulative number of confirmed COVID-19 cases that occurred after January 20, 2020, had a strong positive correlation with the search volumes for the terms coronavirus (R=0.786; P<.001), immune (R=0.745; P<.001), and vitamin (R=0.778; P<.001), and the correlations between variables were all mutually statistically significant. Moreover, these correlations were confirmed on a country basis when we restricted our analyses to the United States, the United Kingdom, Italy, and Korea. Our findings revealed that increases in search volumes for the terms coronavirus and immune preceded the actual occurrences of confirmed cases.

Conclusions
Our study shows that during the initial phase of the COVID-19 crisis, the public’s desire and actions of strengthening their own immune systems were enhanced. Further, in the early stage of a pandemic, social media platforms have a high potential for informing the public about potentially helpful measures to prevent the spread of an infectious disease and provide relevant information about immunity, thereby increasing the public’s knowledge.
Zoom y la educación en ciencias de la salud: ¿medio o mensaje?
Authors: Sánchez Mendiola Melchor , Fortoul van der Goes Teresa I. 
Published: April 2021

Introducción: La pandemia de 2020 ha sido la fuerza más disruptiva en la historia para la educación en ciencias de la salud. Las medidas sanitarias de confinamiento y distanciamiento social obligaron a trasladar la mayoría de las actividades de enseñanza a la modalidad en línea, por lo que universidades y hospitales tuvieron que interactuar a través de modalidades digitales, incluyendo videoconferencias. La plataforma más usada para este fin es Zoom, por lo que es necesario analizar las bondades y limitaciones de esta aplicación en educación en ciencias de la salud.Objetivo: Proveer una actualización y reflexión crítica sobre el uso de Zoom en educación en profesiones de la salud.Método: Revisión narrativa de la literatura y ensayo crítico sobre el tema. El análisis se estructuró de la siguiente forma: uso de videoconferencias durante la pandemia; qué es Zoom, sus ventajas y desventajas; principios educativos y recomendaciones para su mejor uso; conclusiones.Discusión: Los avances tecnológicos de las últimas décadas generaron un escenario propicio para el uso masivo de videoconferencias en tiempo real durante la pandemia, lo que hubiera sido imposible a principios de siglo. La plataforma de Zoom ha sido una de las más utilizadas por su facilidad de uso e interfaz intuitiva. Como con cualquier tecnología en educación, es fundamental utilizar esta plataforma sustentándose en sólidos principios educativos, en lugar de solamente transferir la conferencia tradicional del aula física a la virtual. Es necesario transitar de la “educación remota de emergencia” a una educación en línea adecuadamente planeada, diseñada e implementada, que incluya múltiples herramientas de comunicación sincrónica y asincrónica como elementos del proceso, así como realizar investigación sobre su eficacia y efectos adversos.Conclusiones: La pandemia ha generado profundos cambios en la enseñanza de las profesiones de la salud, incluyendo el uso masivo de videoconferencias en tiempo real. Es necesario documentar estas experiencias y fundamentarlas con investigación de calidad.
Desenvolvimento sustentável de três comunidades atingidas pela construção de uma usina hidrelétrica
Authors: Ferreira Patricia Aparecida , Lima Marina Aparecida , Lima Andreina Del Carmen Camero de 
Published: April 2021

O caso apresenta uma narrativa sobre os impactos da construção de uma usina hidrelétrica em três comunidades e as estratégias adotadas pelo consórcio empreendedor para mitigar tais impactos. Espera-se com este caso demonstrar que a construção de usina não apresenta somente impactos ambientais, mas também transformações políticas, sociais, culturais e econômicas no território em que será alocada. O caso também elucida alguns elementos para que os empreendedores obtenham o licenciamento para construção e operação de uma usina, no entanto, as questões orientadoras para sua análise não recaem sobre a legislação brasileira, mas, sobretudo, instigam um olhar para as relações entre o meio ambiente, o empreendimento e a sociedade. Propõe-se como referência teórica para estudar o caso, as discussões sobre o desenvolvimento sustentável, como uma proposta de desenvolvimento diferenciada, imbuídas de uma crítica ao reducionismo econômico e que consideram as dimensões sociais, culturais, econômicas, ambientais e políticas.
On Quaternion-Gaussian Fibonacci Numbers and Their Properties
Authors: Halici Serpil , Cerda-Morales Gamaliel 
Published: April 2021

Abstract
We study properties of Gaussian Fibonacci numbers. We start with some basic identities. Thereafter, we focus on properties of the quaternions that accept gaussian Fibonacci numbers as coefficients. Using the Binet form we prove fundamental relations between these numbers. Moreover, we investigate whether the quaternions newly defined provide existing some important identities such as Cassini’s identity for quaternions.
A Mean Ergodic Theorem for Affine Nonexpansive Mappings in Nonpositive Curvature Metric Spaces
Authors: Khatibzadeh Hadi , Pouladi Hadi 
Published: April 2021

Abstract
In this paper, we consider the orbits of an affine nonexpansive mapping in Hadamard (nonpositive curvature metric) spaces and prove an ergodic theorem for the inductive mean, which extends the von Neumann linear ergodic theorem. The main result shows that the sequence given by the inductive means of iterations of an affine nonexpansive mapping with a nonempty fixed point set converges strongly to a fixed point of the mapping. A Tauberian theorem is also proved in order to ensure convergence of the iterations.