bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basal cell adenocarcinoma of the maxillary sinus: A case report
Authors: Kojima Masataka , Ito Shin , Tou Miri , Sonoda Kenji , Yoshikawa Akihisa , Ikeda Katsuhisa , Higo Ryuzaburo 
Published: February 2021

Abstract
Background: A basal cell adenocarcinoma (BCAC) is a low-grade malignancy of the salivary glands. A BCAC of the minor salivary gland is a rare disease, which is extremely rare in the maxillary sinus without invading from the palate and buccal mucosa. The histopathological characteristics of a BCAC are similar to those of a basal cell adenoma (BCA). However, BCAC can be differentiated from BCA based on its tendency to invade surrounding tissues. Surgical resection is the first-line treatment for BCACs. We report a case of a BCAC arising from the maxillary sinus minor salivary glands in an 82-year-old man.Case presentation: In 2016, the patient presented with recurrent epistaxis, and he was referred to our department because a tumor was found in his left nasal cavity. Gross resection using the Denker operation was performed. Histopathological examination revealed no surrounding tissue invasion; therefore, BCA was diagnosed. In 2017, the recurrent lesion was resected using endoscopy as much as possible, and the histopathologic findings again revealed a BCA.In 2019, he developed diplopia, frequent epistaxis, and buccal swelling. The recurrence of maxillary sinus tumor was shown again with invasion of surrounding tissues, and we presumed a clinical diagnosis of a left maxillary carcinoma (suspected BCAC). When we performed partial maxillary resection by the Weber–Ferguson incision, we found that the tumor had partially invaded the bone of the orbital floor; thus, the floor of the orbit and orbital fat were partially resected. Finally, the tumor was diagnosed as a BCAC. Conclusion: We report a BCAC arising from the maxillary sinus. This is an extremely rare sinus tumor, and differentiation of BCAC and BCA is important from a clinical or histopathological examination. A partial maxillectomy with a Weber–Ferguson incision was required for complete resection. When a malignancy is suspected in the recurrent maxillary sinus tumor, it is important to have a wider surgical field than that of the previous surgery to ensure complete resection.
Preliminary study on the construction of animal model for non-puerperal mastitis
Authors: Lina Ma , Hongfeng Chen 
Published: February 2021

Abstract
Objection: This qualitative study explored the key factors affecting the occurrence of non-puerperal mast (NPM） and the construction of an animal model which is closer to the characteristics of the disease.Background: The etiological factors and pathogenesis of NPM are unknown, and the incidence, misdiagnosis rate and recurrence rate are high. Previously reported modeling methods vary, reproducibility is poor, and disease characteristics cannot be well characterized, so new animal models are urgently needed for research.Methods: In this study, using female Wistar rats to construct a non-puerperal mastitis animal model by intraperitoneal injection of metoclopramide to simulate hyperprolactinemia + autologous milk injected into the mammary gland to simulate ductal secretions. Results: Pathological results showed that 2 weeks after injection in group C (intraperitoneal injection of metoclopramide for 2 weeks + breast injection of maternal milk mixture twice) and group D (intraperitoneal injection of metoclopramide for 2 weeks + breast injection of maternal milk mixture three times), lipid stasis, periductal inflammation, and massive plasma cell and lymphocyte infiltration were observed,similar to the lesions in patients with human plasma cell mastitis. Conclusions: We believe that we can can establish a non-puerperal mastitis model by altering prolactin levels and ductal secretion stasis in rats.
Influence of implant cover screw loosening on early peri-implant marginal bone loss: a retrospective evaluation of risk factors
Authors: Wuwei Yin , Yong Yang , Zhenzhen Wu , Pei Chen , Zinan Yang , Zekun Gan , Tengfei Zhou , Mianyan Zeng , Hongxing Chu , Mingdeng Rong 
Published: February 2021

Abstract
Background: This study aimed to evaluate the risk factors of cover screw loosening (CSL) and its influence on peri-implant marginal bone during early bone healing process.Methods: A total of 91 implants in 90 patients (75 normal patients and 15 patients with CSL) were included in this study. Panoramic radiographs were taken for the measurement of peri-implant marginal bone loss (MBL). A piece of soft tissue above the cover screw during the second-stage surgery was taken for pathological examination. The differences between the two groups were evaluated and the possible risk factors associated with CSL were analyzed.Results: Increased frequency of CSL showed significant association with maxillary region (p=0.038). The mean MBL at implants with CSL was 0.82 ± 0.56 mm, and it was 0.22 ± 0.20 mm at normal implants (p<0.001). The inflammatory granulation tissue around the loose cover screws showed infiltration of a large number of inflammatory cells.Conclusions: CSL during healing process is associated with early peri-implant MBL. The location of the maxilla is considered as a significant risk factor for CSL.
Unsteady Hybrid-Nanofluid Flow Comprising Ferrousoxide and CNTs Through Porous Horizontal Channel With Dilating/Squeezing Walls
Authors: Bilal Muhammad , Arshad Hamna , Ramzan Muhammad 
Published: February 2021

Abstract
The key objective of the present research is to examine the hybrid magnetohydrodynamics (MHD) nanofluid (Carbon-nanotubes and ferrous oxide-water) CNT−Fe− 3O−4/H−2O flow into a horizontal parallel channel with thermal radiation through squeezing and dilating porous walls. The parting motion is triggered by the porous walls of the channel. The fluid flow is time-dependent and laminar. The channel is asymmetric and the upper and lower walls are distinct in temperature and porosity. With the combination of nanoparticles of Fe3O4 and single and multi-wall carbon nanotubes, the hybrid nanofluid principle is exploited. By using the similarity transformation, the set of partial differential equations (PDEs) of this mathematical model, governed by momentum and energy equations, is reduced to corresponding ordinary differential equations (ODEs). A very simple numerical approach called the Runge-Kutta system of order four along with the shooting technique is used to achieve the solutions for regulating ODEs. MATLAB computing software is used to create temperature and velocity profile graphs for various emerging parameters. At the end of the manuscript, the main conclusions are summarized.
Autophagy inhibition reduces irradiation-induced subcortical white matter injury not by reducing inflammation, but by increasing mitochondrial fusion and inhibiting mitochondrial fission
Authors: Wang Yafeng , Xu Yiran , Zhou Kai , Wang Yong , Li Tao , Xie Cuicui , Zhang Shan , Zhang Xiaoli , Song Juan , Zhu Changlian 
Published: February 2021

Abstract
Background
Radiotherapy is an effective tool in the treatment of malignant brain tumors, but irradiation-induced late-onset toxicity remains a major problem. The purpose of this study was to investigate if genetic inhibition of autophagy has impact on subcortical white matter development in the juvenile mouse brain after irradiation.
Methods
Ten-day-old selective Atg7 knockout (KO) mice and wild-type (WT) littermates were subjected to a single 6 Gy dose of whole-brain irradiation and evaluated at 5 days after irradiation.
Results
Neural Atg7 deficiency partially prevented myelin disruption compared to the WT mice after irradiation, as indicated by myelin basic protein staining. Irradiation induced oligodendrocyte progenitor cell loss in the subcortical white matter, and Atg7 deficiency partly prevented this. There was no significant change between the KO and WT mice in the number of microglia and astrocytes in the subcortical white matter after irradiation. Transcriptome analysis showed there were numbers of differentially expressed genes (DEGs) in both Atg7 KO and WT group after irradiation, but GSEA analysis showed that the GO mitochondrial gene expression pathway was significantly enriched in the remaining DEGs between the KO and WT group after irradiation. Compared with WT mice, expression of the mitochondrial fusion protein OPA1 and phosphorylation of the mitochondrial fission protein DRP1 were dramatically decreased in KO mice under physiological conditions. The protein levels of phosphorylated DRP1 and OPA1 showed no differences in WT mice between the non-irradiated group and the irradiated group but had remarkably increased level in the KO mice after irradiation.
Conclusions
These results indicate that inhibition of autophagy reduces irradiation-induced subcortical white matter injury not by reducing inflammation, but by increasing mitochondrial fusion and inhibiting mitochondrial fission.
Development of Eye Phantoms for Mimicking the Structural Deformation of the Human Cornea Accompanied With Intraocular Pressure Alteration
Authors: Cho Han Saem , Jeoung Sae Chae 
Published: February 2021

Abstract
We developed a fully continuous eye phantom to better understand structural deformation of the cornea under varying intraocular pressure (IOP). The IOP-induced deformation and tension of the eye phantom were investigated using optical coherence tomography and non-contact tonometer readings, respectively. A fixed-cornea eye phantom, which featured a soft cornea, was also used for comparison. We evaluated the corneal structural changes between the two different types of eye phantoms by estimating the central corneal thickness (CCT) and corneal radius of curvature (CRC). For the eye phantom with an initial CCT of 0.55 mm, which is close to the average human CCT, CRC of the fully continuous eye phantoms showed a positive correlation to true IOP, while the CRC of a fixed-cornea eye phantom had a negative correlation. Non-contact tonometry readings for fixed-cornea eye phantoms were higher than those of full-eye phantoms due to the structural and mechanical characteristics. Considering the results from in vitro studies on enucleated human eyeballs, a fully continuous eye phantom is a more suitable choice for mimicking human IOP than a fixed-cornea eye phantom. Use of a more reliable eye phantom for accurate estimation of IOP using tonometry may eventually improve the accuracy of glaucoma screening.
Development of an adaptive template for fast detection of lithographic patterns of light-emitting diode chips
Authors: Weng Wei-Han , Tsai Chen-Yang , Hung Cheng-Yu , Kuo Chung-Feng Jeffrey 
Published: February 2021

Abstract
With the expansion in light-emitting diode (LED) lighting market and technology, control of product quality has become the focus of LED development. To achieve high online production capacity, automated quality detection with object image has been employed for comparison using mostly the standard templates. However, the resulting poor fitting causes misjudgment of the detection system. This study proposes an adaptive template method to improve the system fitting, reduce the system misjudgment, and enhance the detection efficiency. The severely damaged LED chips were screened out based on their grayscale entropy indices and related coefficient indices, which enhanced the reliability of the adaptive template system and accelerated the overall system detection process. To overcome the displacement and scale changes of the lithographic patterns, the scale-invariant feature transform (SIFT) and Harris–Laplace methods were used for comparison. The scale-invariant feature transform (SIFT) and Harris–Laplace methods were used to search and compare the feature points of the chip patterns, with the aim to overcome the displacement and scale changes of the lithographic patterns and establish the adaptive template in real conditions. The fast correlation coefficient comparison method was compared with the adaptive template comparison method proposed in this study. The results showed that the detection accuracy of the new method was 98.36%, which is 15.79% more accurate than the fast correlation coefficient comparison method. In terms of time performance, the method proposed in this study took 0.08s less to complete the partition defect template. Moreover, the average detection time per chip was reduced by another 1.4s, which improved the efficiency by 30.43%. The adaptive template proposed in this study exclusively establish itself based on different lithographic patterns, thus improving the detection efficiency and accuracy of the LED industry, and raising its market competitiveness in the industry.
Influence of Nano-Fluid Lubrication On Single Porous-Layered Journal Bearing: A Hypothetical Approach
Authors: BHATTACHARJEE BIPLAB , CHAKRABORTI PRASUN , CHOUDHURY KISHAN 
Published: February 2021

Abstract
In this article a mathematical model of single layered nano-fluid lubricated PJB (porous journal bearing) has been formulated. The nano-lubricant's impact on the efficiency of said journal bearing has been studied using modified Darcy's law and boundary conditions. The different nanoparticles often used as an additive in industrial lubricating oils improve their viscosity significantly. The brief description of dimensionless performance characteristics of the investigated bearing was obtained by the use of the nano-lubricant's modified Krieger-Dougherty viscosity model. The observations revealed that the output characteristics are substantially improved by using nano-lubricant. The present study was validated by comparing the findings of recently published data with micropolar fluid and was found to be completely compatible since data with nano-lubricant are still unavailable.
Hierarchical tubular MoP/MoS2 composite with enhanced electrochemical hydrogen evolution activity
Authors: Wang Peiyuan , Wang Xiaoqian , Diao Renyi , Guo Yujie , Wang Yuxiang , Zhou Chao , Xie Ke-Feng , Sun Shumin , Zhang Yong-Hui 
Published: February 2021

Abstract
Electrocatalytic production of hydrogen from water is a promising and sustainable strategy. Herein, hierarchical tubular MoP/MoS2 composites with the wall composed of loosely stacked nanosheets were fabricated through partially phosphating the tubular MoS2. As an electrocatayst for hydrogen evolution reaction (HER), the hierarchical tubular MoP/MoS2 composite displayed a superior HER activity with a low overpotential (101 mV) to obtain a current density of 10 mA/cm2, small Tafel slope (56 mV/dec). Moreover, the MoP/MoS2 composite demonstrate superior long-term durability in acid electrolytes. The excellent catalytic activity of MoP/MoS2 composite may be ascribed to its hierarchical structure: hierarchical porous structure can offer mass diffusion pathways, and the nanosheets with MoP/MoS2 heterojunctions can provide rich active sites for HER. Density functional theory (DFT) calculations reveal that more favorable H* adsorption kinetics on the surface of the MoP/MoS2 composite during the HER process than pristine MoP and MoS2. This work can offer a strategy to design high performance electrocatalysts for HER applications.
LncRNA LINC00520 Aggravates Cell Proliferation and Migration in Lung Adenocarcinoma via a Positive Feedback Loop
Authors: Huang Wen , Wang Xinxing , Wu Fubing , Xu Fanggui 
Published: February 2021

Abstract
Background: Lung adenocarcinoma (LUAD) is the most common histological subtype of primary lung cancer. Thus, to figure out the biomarker of diagnosis for LUAD is of great significance. Long non-coding RNAs (lncRNAs) are previously revealed to exert vital effects in numerous cancers. LncRNA long intergenic non-protein coding RNA 520 (LINC00520) served as an oncogene in certain cancers. Therefore, our report was specially designed to probe role of LINC00520 in LUAD. Results: LINC00520 expression was detected by RT-qPCR. Next, function of LINC00520 in LUAD was verified by in vitro loss-of-function experiments. As for LINC00520 regulatory mechanism in LUAD, we conducted pull down, ChIP, RIP, and luciferase reporter assays. We found that LINC00520 was upregulated in LUAD. Additionally, LINC00520 upregulation suggested the poorer prognosis for patients with LUAD. Furthermore, LINC00520 downregulation suppressed LUAD cell proliferation and migration and induced cell apoptosis. Simultaneously, forkhead box P3 (FOXP3) is identified as the transcription factor (TF) to transcriptionally activate LINC00520. Moreover, LINC00520 positively upregulated FOXP3 via sponging miR-3611 in LUAD. Subsequently, rescue experiments delineated that miR-3611 downregulation or FOXP3 overexpression could reverse the effect of silenced LINC00520 on proliferative and migratory capabilities in LUAD. Conclusion: This study ﬁrst put forward and proved that lncRNA LINC00520 facilitated cell proliferative and migratory abilities in LUAD through interacting with miR-3611 and targeting FOXP3, which may provide a potential novel insight for treatment of LUAD.
AWJM of Mg-based composites with different nanoparticle contents
Authors: Mardi Bimla , Dixit Amit Rai , Pramanik Alokesh , Hloch Sergej , Havizdos Pavol , Mallick Ashis , Nag Akash 
Published: February 2021

Abstract
This paper investigates the influence of jet traverse speed and water jet pressure of abrasive water jet machining (AWJM) on the magnesium-based metal matrix nanocomposites (Mg-MMNC) reinforced with 50 nm (average particle size) 0.66 and 1.11 wt.% Al2O3.The extent of grooving caused by abrasive particle and irregularities in AWJ machined surface with respect to traverse speed and cutting depth was investigated. The nanoindentation results hows softening of the material defended by higher reinforcement content nanocomposite due to presence of sufficient amount of nanoparticles protecting the surface from being damaged. The values of selected amplitude parameters viz. average roughness (Ra), maximum height of peak (Rp), maximum depth of valleys (Rv) presenting the comparatively smooth surface finish in 1.11 wt.% reinforced composite at high (500 mm/min) speed. Moreover, the high water pressure AWJM produces the better surface quality due to sufficient material removal and proper cleaning of debris from the machining zone as compare to the low water pressure, low transverse speed and low abrasive mass flow rate.
Atrial Fibrillation Catheter Ablation Complications in Obese and Diabetic Patients: Insights from the US Nationwide Inpatient Sample 2005-2013.
Authors: D’Souza Shawn , Elshazly Mohamed B. , Dargham Soha R . , Donnellan Eoin , Asaad Nidal , Hayat Sajjad , Kanj Mohamed , Baranowski Brian , Wazni Oussama , Saliba Walid , Khalil Charbel Abi 
Published: February 2021

Abstract
Obesity and diabetes are risk factors for atrial fibrillation (AF) incidence and recurrence after catheter ablation. However, their impact on post-ablation complications in real-world practice is unknown. Using the Nationwide Inpatient Sample (2005–2013), we examine annual trends in AF ablations and outcomes in US patients with obesity and diabetes and perform multivariate analyses to assess whether they are independently associated with adverse outcomes. Our primary outcome included the composite of in-hospital complications or death. Annual trends for primary outcome, length-of-stay (LOS) and total inflation-adjusted hospital charges were examined. An estimated 106,462 AF-ablations were performed in the US from 2005–2013. There was a gradual annual increase in ablations performed in obese and diabetic patients and complication rates. The primary outcome rate was 11.7% in obese vs. 8.2% in non-obese and 10.7% in diabetic vs. 8.2% in non-diabetic patients (p < 0.001). Obesity was independently associated with increased complications (adjusted-OR, 95% CI:1.39, 1.20–1.62), longer LOS (1.36, 1.23–1.49), and higher charges (1.16, 1.12–1.19). Diabetes was only associated with longer LOS (1.27, 1.16–1.38). Hence obesity, but not diabetes, is an independent risk factor for immediate post AF ablation complications and higher costs. Future studies should investigate whether weight loss prior to ablation reduces complications and costs.
Transcriptome Analysis Reveals Potential Function of Long Non-coding RNAs in 20-hydroxyecdysone Regulated Autophagy in Bombyx Mori
Authors: Qiao Huili , Wang Jingya , Wang Yuanzhuo , Yang Juanjuan , Wei Bofan , Li Miaomiao , Wang Bo , Li Xiaozhe , Cao Yang , Tian Ling , Li Dandan , Yao Lunguang , Kan Yunchao 
Published: February 2021

Abstract
Background: 20-hydroxyecdysone (20E) plays important roles in insect molting and metamorphosis. 20E-induced autophagy has been detected during the larval–pupal transition in different insects. In Bombyx mori, autophagy is induced by 20E in the larval fat body. Long non-coding RNAs (lncRNAs) function in various biological processes in many organisms, including insects. Many lncRNAs have been reported to be potential for autophagy occurrence in mammals, but it has not been investigated in insects. Results: RNA libraries from the fat body of B. mori dissected at 2 and 6 h post-injection with 20E were sequenced, and comprehensive analysis of lncRNAs and mRNAs was performed. A total of 1035 lncRNAs were identified, including 905 lincRNAs and 130 antisense lncRNAs. Compared with mRNAs, lncRNAs had longer transcript length and fewer exons. 132 lncRNAs were found differentially expressed at 2 h post injection, compared with 64 lncRNAs at 6 h post injection. Thirty differentially expressed lncRNAs were common at 2 and 6 h post-injection, and were hypothesized to be associated with the 20E response. Target gene analysis predicted 6493 lncRNA-mRNA cis pairs and 42797 lncRNA-mRNA trans pairs. The expression profiles of LNC_000560 were highly consistent with its potential target genes, Atg4B, and RNAi of LNC_000560 significantly decreased the expression of Atg4B. These results indicated that LNC_000560 was potentially involved in the 20E-induced autophagy of the fat body by regulating Atg4B. Conclusions: This study provides the genome-wide identification and functional characterization of lncRNAs associated with 20E-induced autophagy in the fat body of B. mori. LNC_000560 and its potential target gene were identified to be related to 20-regulated autophagy in B. mori. These results will be helpful for further studying the regulatory mechanisms of lncRNAs in autophagy and other biological processes in this insect model.
Mitochondrial protease Lonp1 localizes to the nucleus in response to heat shock
Authors: Gibellini Lara , Borella Rebecca , Gaetano Anna De , Zanini Giada , Tartaro Domenico Lo , Carnevale Gianluca , Beretti Francesca , Losi Lorena , Biasi Sara De , Nasi Milena , Forcato Mattia , Cossarizza Andrea , Pinti Marcello 
Published: February 2021

Abstract
The coordinated communication between the mitochondria and nucleus is essential for cellular activities. Nonetheless, the pathways involved in this crosstalk are scarcely understood. The protease Lonp1 was previously believed to be exclusively located in the mitochondria, with an important role in mitochondrial morphology, mtDNA maintenance, and cellular metabolism, in both normal and neoplastic cells. However, we recently detected Lonp1 in the nuclear, where as much as 22% of all cellular Lonp1 can be found. Nuclear localization is detectable under all conditions, but the amount is dependent on a response to heat shock (HS). Lonp1 in the nucleus interacts with heat shock factor 1 (HSF1) and modulates the HS response. Furthermore, we found three splicing variants of Lonp1 mRNA that coexist in cells and generate three Lonp1 isoforms (ISO1, ISO2 and ISO3) with differential subcellular distributions. All three isoforms move into the nucleus under HS, and ISO2 is most frequently upregulated in neoplastic cells compared to ISO1 and ISO3. These findings reveal a novel extramitochondrial function for Lonp1 in response to stress.