bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deduction and Common Notions in Alexander’s Commentary on Aristotle’s Metaphysics A 1–2
Authors: de Haas Frans A. J. 
Published: October 2021

Abstract
In this paper I explore the ways in which Alexander of Aphrodisias employs and develops so-called ‘common notions’ as reliable starting points of deductive arguments. He combines contemporary developments in the Stoic and Epicurean use of common notions with Aristotelian dialectic, and axioms. This more comprehensive concept of common notions can be extracted from Alexander’s commentary on Metaphysics A 1–2. Alexander puts Aristotle’s claim that ‘all human beings by nature desire to know’ in a larger deductive framework, and adds weight to Aristotle’s use of the common understanding of the notion of ‘wisdom’. Finally I will indicate how these upgraded common notions are meant to play an important role in the general framework of metaphysics as a science.
PENILAIAN KINERJA DOSEN DALAM BIMBINGAN SKRIPSI
Authors: Sari Siska Mayang , Ennimay Ennimay 
Published: October 2021

Tenaga dosen sebagai salah satu komponen penting dalam Pendidikan tinggi memiliki tugas dalam melaksanakan Tridharma Perguruan Tinggi salah satunya adalah membimbing tugas akhir/ skripsi dalam komponen melaksanakan pengajaran dan Pendidikan. Skripsi merupakan tugas akhir yang harus diselesaikan mahasiswa pada program sarjana sebagai syarat memperoleh gelar sarjana keperawatan (S.Kep). Penelitian ini bertujuan untuk mengetahui hubungan penilaian kinerja dosen dalam bimbingan skripsi dengan kualitas skripsi. Metode penelitian yang digunakan adalah jenis penelitian kuantitatif analitik, dengan desain korelasi dan pendekatan cross sectional. Populasi penelitian ini adalah seluruh lulusan S.Kep tahun ajaran 2019/2020 dan 2020/2021 yang masih terdaftar menjadi mahasiswa Ners yang berjumlah 77 orang. Teknik pengambilan sampel menggunakan total Sampling. Cara pengumpulan data pada penelitian ini menggunakan kuisioner dan telusur dokumen Skripsi pada prodi S1 Keperawatan. Analisis data menggunakan bivariat menggunakan Chi-Square. Hasil uji chi-square didapatkan p-value 0.219 (>0.05) yang bermakna tidak terdapat hubungan antara kinerja dosen dalam bimbingan skripsi dengan kualitas skripsi mahasiswa berdasarkan persepsi mahasiswa. Meskipun demikian, diharapkan kepada prodi S1 Keperawatan STIKes Hang Tuah Pekanbaru untuk menerapkan penilaian kinerja dosen dalam bimbingan skripsi sebagai salah satu upaya evaluasi bimbingan skripsi dan kinerja dosen.
Assessment Of Occupational Burnout And Its Correlates Among Medical Doctors in Nepal during COVID-19 pandemic: A cross-sectional study
Authors: Sharma Pawan , Singh Swarndeep , Tiwari Umakanta , Ranjan Rahul , Lekhak Nabin , Acharya Sajan 
Published: October 2021

Introduction: The current COVID-19 pandemic has increased emotional and physical toll on healthcare workers. The burnout among doctors could be another psychological outcome due to this. Considering the dearth of literature we planned this study with an aim to explore burnout and its correlates among medical doctors of Nepal.
Material And Method: An online survey using a cross-sectional design and purposive sampling was conducted during the lock-down due to COVID-19 pandemic in Nepal. The tools used were basic proforma, Copenhagen Burn out Inventory (CBI) and Perceived Stress Scale (PSS). Descriptive and inferential statistical analysis (bivariate analysis followed by multiple linear regression) was performed with an objective to study prevalence of burnout and its correlates among the medical doctors.
Results: The average age of participants was 30.44 years with the majority being male. All the study participants reported moderate to severe level of perceived stress. Around half of them reported moderate to high burnout. The multiple linear regression analyses showed that perceived stress, and working in surgical department were significant correlates for personal and work-related burnout among medical doctors. Additionally, being front-line worker was a significant correlate for client-related burnout.
Conclusion: The burden and severity of burnout and perceived stress reported by the medical doctors during COVID-19 pandemic in the present study, suggests it to be an important mental health issue in Nepal. Suitable interventions for targeting this urgent issue of effectively reducing the burnout are warranted.
Sociodemographic Profiles And Psychiatric Comorbidities Among Patients With Alcohol Dependence In Western Nepal
Authors: Belbase M. , Jalan R.K. , Adhikari J. 
Published: October 2021

Introduction: Alcohol is a potent drug that causes acute and chronic changes in almost all neurochemical systems and heavy drinking can produce serious temporary psychological symptoms including depression, anxiety and psychoses. Alcoholism is clinically heterogenous disorder with variable age of onset, drinking patterns, severity and comorbidity with other mental disorders. There is a gender difference in many aspect of alcohol use. The aim of the study was to study the sociodemographic profile, severity, gender difference and psychiatric comorbidities in patient with alcohol dependence syndrome in Nepalese population.
Material And Method: This is a hospital based study done in patients coming to Nepalgunj Medical College, Kohalpur over a period of one year from June 2019 to May 2020 on consecutive serial basis. Diagnosis of alcohol dependence was made based on International Classification of Disease-10 (ICD-10) criteria. Semi structured proforma and Severity of Alcohol Dependence Questionnaire (SADQ) was applied in those patients and recorded accordingly. The data was analyzed using SPSS.
Results: Out of 40 patients studied (N-40), 37 (92.5 %) were male and 3 (7.5 %) were female. Alcohol dependence is most common in the age bracket of 30-39 (43.1%) followed by 40-49 (33.4 %) with mean age of 40.3 years and the mean age of duration of alcohol use being 13.45 years. The mean amount of alcohol consumed per day is 92.25 grams. The SADQ scores, age of first alcohol use, duration of alcohol use in years and daily amount of alcohol use in grams is significantly different between male and female. Similarly there is severe alcohol dependence in 75 % while moderate level in 25 % of study population. Regarding psychiatric comorbidities, 90 % have comorbid other substance use disorder followed by anxiety disorders in 37.5 %, personality disorders in 35 %, mood disorders in 32.5 %, deliberate self harm in 30 % and psychotic disorders in 12.5 %.
Conclusion: Alcohol dependence is most commonly found in young and adults of various age group. Age of first alcohol use, duration of alcohol use in years and daily amount of alcohol use in grams is significantly different between male and female. Alcohol dependence is comorbid with multiple psychiatric entities.
Patient Satisfaction with Doctor-Patient Interaction using SKIP-11 and Its Associated Factors among Type 2 Diabetics in Primary Care.
Authors: Mohd Yusoff Siti Suhaila , Pah Kiam George Wong , Yaacob Lili Husniati , Draman Nani 
Published: October 2021

ABSTRACT
Introduction: The quality of diabetes care is widely suboptimal, and most of the interventions depend on the active involvement and participation of patients. Understanding and determining patient related factors can help primary care providers pay more attention and give greater care to those patients. This will improve patient satisfaction, which further enhances compliance with or adherence to diabetic treatment. Therefore, this study aims to determine patient satisfaction with doctor-patient interaction and its associated factors among patients with type 2 diabetes mellitus.
Materials and Methods: This cross-sectional study was performed among adults who had had diabetes for at least six months. Participants were selected by systemic random sampling in the outpatient clinic of the University Hospital. Patient satisfaction with doctor-patient interaction was measured using 11- items with a three-domain version of the “Skala Kepuasan Interaksi Perubatan-11” questionnaire. The total scores ranged from 11 to 55, and those who scored 44 and above (> 80%) were considered satisfied.
Results: A total of 417 patients were recruited in the study. 60% were satisfied with their doctor-patient interactions. Among the subtypes in the satisfied group, the domain of rapport had the highest percentage of satisfaction at 77.7%. HbA1c was found to be significant associated with patient satisfaction with doctor-patient interaction (95% CI: 0.81, 0.97; p = 0.008)
Conclusion: 60% of the participants clearly illustrated positive feedback and were more satisfied with their doctor-patient interactions. HbA1c was found to be significantly associated with patient satisfaction concerning doctor-patient interaction
Implementation Corporate Social Responsibility Of Regional Owned Business Agencies To Help Handling Covid-19 In Kendal
Authors: Kuswandriyo Andhang 
Published: October 2021

Abstract
Improve the welfare of the community in the area around the company and corporate responsibility. This can happen because the community feels affected by the environment that comes from the company's operations. The improvement of conditions in the social environment is one way of fulfilling the responsibilities known as corporate social responsibility or CSR. The definition of economic democracy in the national economy is based on the principles of unity, equity, sustainability of function, environmental mobilization, independence, and in maintaining the balance of development and national economic unity, it is important to support the 'main economic institutions; to determine the welfare of the people. CSR activities for the community are a process of migration and are related to the existing resources in the community. Currently, Social Welfare is no longer voluntary in nature but it has become the responsibility of many companies to implement it, although so far there have been no serious sanctions imposed on non-CSR companies.
Keywords: CSR; Corporate social responsibility; Law of the Republic of Indonesia Number 40 of 2007; Community Welfare
BUSINESS MANAGEMENT LITERATION AND LEGALITY E -COMMERCE IN THE PANDEMIC
Authors: Takarini Nurjanti , Mahanani Anajeng Esri Edhi , Wahyudi Eko 
Published: October 2021

This article discusses the community service activities that have been carried out in the PKK RT / RW 005/005 Manukan Kulon group, Surabaya. This community service activity is held with the consideration that the author as an academic feels the need to participate in parsing the economic problems in society caused by the Covid-19 pandemic. The impact of the Covid-19 pandemic, which created many unemployment clusters due to layoffs from closed businesses, as well as macroeconomic impacts that affect the economic conditions of the Indonesian State, require the contribution of solutions from all parties, including academics who have the dharma of community service. Business management literacy andlegality are e-commerce implemented as a means of providing understanding to the community and building PKK groups that are legally aware and smart in managing their business by utilizing information technology media.

Keywords : Community Service, Pandemic Covid 19, Business Management, Legality, E Commerce.
PEMERIKSAAN SENSIBILITAS DAN STIMULASI SOMATOSENSORIK PADA KAKI LANSIA DI UPTS TRESNA WREDHA PANDAAN JAWA TIMUR
Authors: Khabib abdullah  
Published: October 2021

Lansia memiliki risiko jatuh yang cukup besar. Menurut WHO, bahwa lansia usia 65 tahun ke atas memiliki risiko jatuh sebesar 28-35%. Lansia yang tinggal di panti jompo memiliki risiko jatuh yang lebih besar dibandingkan dengan lansia yang tinggal di rumah pribadi. Salah satu penyebab lansia mudah terjatuh adalah penurunan fungsi keseimbangan. Secara konsep, keseimbangan gerak terdiri dari komponen-komponen penglihatan, fungsi vestibular, fungsi muskuloskeletal dan sensibilitas telapak kaki. Kemampuan sensibilitas telapak kaki merupakan kemampuan lansia dalam merasakan sentuhan/taktil pada kaki dan kemampuan merasakan gerakan/proprioseptif pada kaki. Fungsi taktil dan proprioseptif pada kaki inilah yang menjadi pondasi kemampuan berjalan tanpa terjatuh atau kehilangan keseimbangan. Jika komponen sensibilitas telapak kaki tadi mengalami penurunan, maka lansia akan berpotensi mengalami gangguan keseimbangan saat berjalan. Sehingga tujuan dilakukan kegiatan ini adalah untuk memeriksa sensibilitas telapak kaki lansia penghuni panti dan untuk memberikan stimulasi rangsangan pada reseptor taktil dan proprioseptor diatas. Kegiatan ini dilaksanakan pada Sabtu 29 Mei 2021 secara luring dengan sasaran PkM adalah lansia di Panti Tresna Wredha Pandaan. Teknik yang digunakan adalah pemeriksaan dan intervensi fisioterapi secara langsung dengan hasil 22 lansia mengalami gangguan sensibilitas ringan, 3 lansia mengalami gangguan sensibilitas sedang dan 15 mengalami gangguan sensibilitas berat. Setelah diberikan stimulasi, sebagian besar lansia merasakan nyaman dan ringan saat berjalan, dan bahagia karena merasa diperhatikan. Untuk saran kegiatan ini adalah mengajarkan stimulasi pada pengelola panti dan perawat panti, serta lansia di panti, untuk menghafal gerakan stimulasi supaya manfaat stimulasi lebih optimal.
ULTIMATE FRISBEE: NOVA PRÁTICA ESPORTIVA NOS CURRÍCULOS ESCOLARES
Authors: Lettnin Carla da Conceição , Aguilera Carlos Julio González , Dewes Renan Alex Kochhann , De Souza Maurício Abade 
Published: October 2021

Este estudo, descritivo exploratório, apresenta o projeto de extensão que pretende proporcionar inovação de práticas físico-esportivas nos currículos escolares. Neste estudo 31 jogadores responderam questões abertas e fechadas sobre o perfil dos praticantes de Ultimate Frisbee (UF). Os dados quantitativos foram analisados por estatística descritiva e os qualitativos por Análise de Conteúdo. Os resultados apontaram que o UF é acessível a todos os níveis de ensino e faixas-etárias. Entretanto ainda é mais praticado por meninos. Os praticantes de UF buscam lazer, encontrar amigos e divertir-se. Os Aspectos Morais e Sociais diferenciam esta modalidade e, por isso, na opinião dos praticantes, deveriam estar nos currículos escolares. A escola e os amigos são os maiores difusores da modalidade e as escolas e as praças públicas os lugares mais procurados para a prática. Logo, ações e investimentos deveriam ocorrer nesses espaços.
Numerical Investigation of Oil–Water Exchange Behaviors in Shale During Post-Fracturing Soaking Periods
Authors: Wang Fei , Chen Qiaoyun , Zhang Jingchen , Ruan Yingqi , Zhuang Ye , Zhu Jian , Zhang Shicheng 
Published: October 2021

Fracturing fluid imbibition and retention are treated as a main mechanism for oil production from shale reservoirs. However, the oil–water exchange phenomenon during post-fracturing soaking periods has not been thoroughly studied. In this study, a water–oil flow model is built to investigate the water imbibition and oil drainage phenomenon in hydraulically fractured shale. With the developed numerical simulator, the main characteristics of post-fracturing soaking, that is, pressure diffusion, water imbibition, and especially, the oil–water exchange behavior are simulated. Three key time points, that is, oil–water exchange equilibrium, steady exchange efficiency, and oil breakthrough in fracture are found. The oil–water exchange efficiency and exchange volume are also calculated. Moreover, the proposed model is validated by field wellhead pressure dynamics, indicating a relevance of time between the oil–water exchange efficiency and the wellhead pressure falloff derivatives. Finally, the influences of shale permeability, wettability, fracture complexity, and oil viscosity on the oil–water exchange behavior are investigated. Results indicate that the matrix of oil-wet shale almost does not suck water and discharge oil, and only the oil in natural fractures exchanges with the water in hydraulic fractures. The water-wet shale with low permeability, high oil viscosity, and few natural fractures needs extra soaking time to achieve good oil–water exchange performance. The suitable soaking period for the water-wet base case in this study is from 17.25 to 169 days, among which 64 days is the optimal soaking time.
Potential Value of Expiratory CT in Quantitative Assessment of Pulmonary Vessels in COPD
Authors: Cao Xianxian , Gao Xiaoyan , Yu Nan , Shi Meijuan , Wei Xia , Huang Xiaoqi , Xu Shudi , Pu Jiantao , Jin Chenwang , Guo Youmin 
Published: October 2021

Objective: To investigate the associations between intrapulmonary vascular volume (IPVV) depicted on inspiratory and expiratory CT scans and disease severity in COPD patients, and to determine which CT parameters can be used to predict IPVV.Methods: We retrospectively collected 89 CT examinations acquired on COPD patients from an available database. All subjects underwent both inspiratory and expiratory CT scans. We quantified the IPVV, airway wall thickness (WT), the percentage of the airway wall area (WA%), and the extent of emphysema (LAA%−950) using an available pulmonary image analysis tool. The underlying relationship between IPVV and COPD severity, which was defined as mild COPD (GOLD stage I and II) and severe COPD (GOLD stage III and IV), was analyzed using the Student's t-test (or Mann-Whitney U-test). The correlations of IPVV with pulmonary function tests (PFTs), LAA%−950, and airway parameters for the third to sixth generation bronchus were analyzed using the Pearson or Spearman's rank correlation coefficients and multiple stepwise regression.Results: In the subgroup with only inspiratory examinations, the correlation coefficients between IPVV and PFT measures were −0.215 ~ −0.292 (p &lt; 0.05), the correlation coefficients between IPVV and WT3−6 were 0.233 ~ 0.557 (p &lt; 0.05), and the correlation coefficient between IPVV and LAA%−950 were 0.238 ~ 0.409 (p &lt; 0.05). In the subgroup with only expiratory scan, the correlation coefficients between IPVV and PFT measures were −0.238 ~ −0.360 (p &lt; 0.05), the correlation coefficients between IPVV and WT3−6 were 0.260 ~ 0.566 (p &lt; 0.05), and the correlation coefficient between IPVV and LAA%−950 were 0.241 ~ 0.362 (p &lt; 0.05). The multiple stepwise regression analyses demonstrated that WT were independently associated with IPVV (P &lt; 0.05).Conclusion: The expiratory CT scans can provide a more accurate assessment of COPD than the inspiratory CT scans, and the airway wall thickness maybe an independent predictor of pulmonary vascular alteration in patients with COPD.
Resting-State Functional Magnetic Resonance Imaging and Functional Connectivity Density Mapping in Patients With Optic Neuritis
Authors: Song Ke , Wang Yong , Ren Mei-Xia , Li Jiao , Su Ting , Chen Si-Yi , Shao Yi , Lv Ya-Li 
Published: October 2021

Background: Using resting-state functional connectivity (rsFC), we investigated alternations in spontaneous brain activities reflected by functional connectivity density (FCD) in patients with optic neuritis (ON).Methods: We enrolled 28 patients with ON (18 males, 10 females) and 24 healthy controls (HCs; 16 males, 8 females). All subjects underwent functional magnetic resonance imaging (fMRI) in a quiet state to determine the values of rsFC, long-range FCD (longFCD), and short-range FCD (IFCD). Receiver operating characteristic (ROC) curves were generated to distinguish patients from HCs.Results: The ON group exhibited obviously lower longFCD values in the left inferior frontal gyrus triangle, the right precuneus and the right anterior cingulate, and paracingulate gyri/median cingulate and paracingulate gyri. The left median cingulate and paracingulate gyri and supplementary motor area (SMA) were also significantly lower. Obviously reduced IFCD values were observed in the left middle temporal gyrus/angular gyrus/SMA and right cuneus/SMA compared with HCs.Conclusion: Abnormal neural activities were found in specific brain regions in patients with ON. Specifically, they showed significant changes in rsFC, longFCD, and IFCD values. These may be useful to identify the specific mechanism of change in brain function in ON.
Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate
Authors: Chen Wanxin , Sun Xiaoxia , Zhan Libin , Zhou Wen , Bi Tingting 
Published: October 2021

Background and Purpose: Neurodegenerative diseases are associated with metabolic disturbances. Pyruvate dehydrogenase E1 component subunit alpha (PDHA1) is an essential component in the process of glucose metabolism, and its deficiency exists in various diseases such as Alzheimer’s disease (AD), epilepsy, Leigh’s syndrome, and diabetes-associated cognitive decline. However, the exact role of PDHA1 deficiency in neurodegenerative diseases remains to be elucidated. In this study, we explored the effect of PDHA1 deficiency on cognitive function and its molecular mechanism.Methods: A hippocampus-specific Pdha1 knockout (Pdha1–/–) mouse model was established, and behavioral tests were used to evaluate the cognitive function of mice. Transmission electron microscopy (TEM) was performed to observe the morphological changes of the hippocampus. The lactate level in the hippocampus was measured. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting were used to explore the possible mechanism of the effect of PDHA1 on cognition.Results:Pdha1 knockout damaged the spatial memory of mice and led to the ultrastructural disorder of hippocampal neurons. Lactate accumulation and abnormal lactate transport occurred in Pdha1–/– mice, and the cyclic AMP-protein kinase A-cAMP response element-binding protein (cAMP/PKA/CREB) pathway was inhibited.Conclusion: Lactate accumulation caused by PDHA1 deficiency in the hippocampus may impair cognitive function by inhibiting the cAMP/PKA/CREB pathway.
LncRNA GAPLINC Promotes Renal Cell Cancer Tumorigenesis by Targeting the miR-135b-5p/CSF1 Axis
Authors: Wang Siyuan , Yang Xiaorong , Xie Wenjie , Fu Shengqiang , Chen Qiang , Li Zhilong , Zhang Zhicheng , Sun Ting , Gong Binbin , Ma Ming 
Published: October 2021

BackgroundLong noncoding RNAs (lncRNAs) are closely related to the occurrence and development of cancer. Gastric adenocarcinoma-associated, positive CD44 regulator, long intergenic noncoding RNA (GAPLINC) is a recently identified lncRNA that can actively participate in the tumorigenesis of various cancers. Here, we investigated the functional roles and mechanism of GAPLINC in renal cell carcinoma (RCC) development.MethodsDifferentially expressed lncRNAs between RCC tissues and normal kidney tissues were detected by using a microarray technique. RNA sequencing was applied to explore the mRNA expression profile changes after GAPLINC silencing. After gain- and loss-of-function approaches were implemented, the effect of GAPLINC on RCC in vitro and in vivo was assessed by cell proliferation and migration assays. Moreover, rescue experiments and luciferase reporter assays were used to study the interactions between GAPLINC, miR-135b-5p and CSF1.ResultsGAPLINC was significantly upregulated in RCC tissues and cell lines and was associated with a poor prognosis in RCC patients. Knockdown of GAPLINC repressed RCC growth in vitro and in vivo, while overexpression of GAPLINC exhibited the opposite effect. Mechanistically, we found that GAPLINC upregulates oncogene CSF1 expression by acting as a sponge of miR-135b-5p.ConclusionTaken together, our results suggest that GAPLINC is a novel prognostic marker and molecular therapeutic target for RCC.