bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of NT-proBNP as an objective marker of postoperative heart failure after coronary artery bypass surgery: a prospective observational study
Authors: Jiang Huiqi , Holm Jonas , Friberg Örjan , Vanky Farkas , Vidlund Mårten , Tajik Bashir , Yang Yanqi , Svedjeholm Rolf 
Published: July 2021

Abstract
Background
Postoperative heart failure (PHF) is the main cause for mortality after cardiac surgery but unbiased evaluation of PHF is difficult. We investigated the utility of postoperative NT-proBNP as an objective marker of PHF after coronary artery bypass surgery (CABG).

Methods
Prospective study on 382 patients undergoing isolated CABG for acute coronary syndrome. NT-proBNP was measured preoperatively, the first (POD1) and third postoperative morning (POD3). A blinded Endpoints Committee used prespecified criteria for PHF. Use of circulatory support was scrutinized.

Results
After adjusting for confounders PHF was associated with 1.46 times higher NT-proBNP on POD1 (p = 0.002), 1.54 times higher on POD3 (p < 0.0001). In severe PHF, NT-proBNP was 2.18 times higher on POD1 (p = 0.001) and 1.81 times higher on POD3 (p = 0.019). Postoperative change of NT-proBNP was independently associated with PHF (OR 5.12, 95% CI 1.86–14.10, p = 0.002). The use of inotropes and ICU resources increased with incremental quartiles of postoperative NT-proBNP.

Conclusions
Postoperative NT-proBNP can serve as an objective marker of the severity of postoperative myocardial dysfunction. Due to overlap in individuals, NT-proBNP is useful mainly for comparisons at cohort level. As such, it provides a tool for study purposes when an unbiased assessment of prevention or treatment of PHF is desirable.

Trial registration
ClinicalTrials.gov Identifier: NCT00489827https://clinicaltrials.gov/ct2/show/NCT00489827?term=glutamics&draw=2&rank=1.
Embolization with MVP (Micro Vascular Plug®): experience on 104 patients in emergent and elective scenarios
Authors: Giurazza Francesco , Ierardi Anna Maria , Contegiacomo Andrea , Corvino Fabio , Carrafiello Giampaolo , Niola Raffaella 
Published: July 2021

Abstract
Aim
To describe a 3 years experience of peripheral arterial embolization with Micro Vascular Plug (MVP) (Medtronic, USA).

Materials and methods
The following parameters were investigated: type of vascular injury, anticoagulation therapy at time of procedure, anatomical district, caliper of the target artery, course of the landing zone, additional embolics, technical and clinical success, device related clinical complications. Technical success was defined as complete embolization without deployment of additional embolics after MVP release. Primary clinical success was considered as hemodynamic stability in emergency setting and resolution of the underlying vascular pathology in elective cases; secondary clinical success was considered clinical success after a second embolization session.

Results
116 MVP have been released in 104 patients (67 males and 37 females; mean age 61.3 years). The pullback release technique was adopted in each case. 85 patients were treated in emergent settings while in 19 patients the procedure was scheduled. The overall technical success was 75%. Primary clinical success was 96.1%, secondary clinical success 3% and clinical failure 0.9%. No statistical differences in terms of effectiveness were observed among patients assuming anticoagulation (p-value = 0.6). A straight and longer landing zone were statistically associated with higher technical success compared to curved and shorter ones, (p-values < 0.001 and = 0.048 respectively). MVP-3 and MVP-5 were the most frequently adopted models in this sample, in 29.8% and 49% of the patients respectively. No clinically adverse events directly related to MVP occurred; in 3 cases device migration was registered without clinical complications.

Conclusion
MVP is a safe and effective embolic agent. While eventual concomitant anticoagulation therapy did not influence the technical outcome, straight course and length of the landing zone are essential parameters to evaluate before deployment.
AutoShare: Virtual community solar and storage for energy sharing
Authors: Lee Stephen , Shenoy Prashant , Ramamritham Krithi , Irwin David 
Published: July 2021

AbstractResidential solar installations are becoming increasingly popular among homeowners. However, renters and homeowners living in shared buildings cannot go solar as they do not own the shared spaces. Community-owned solar arrays and energy storage have emerged as a solution, which enables ownership even when they do not own the property or roof. However, such community-owned systems do not allow individuals to control their share for optimizing a home’s electricity bill. To overcome this limitation, inspired by the concept of virtualization in operating systems, we propose virtual community-owned solar and storage—a logical abstraction to allow individuals to independently control their share of the system. We argue that such individual control can benefit all owners and reduce their reliance on grid power. We present mechanisms and algorithms to provide a virtual solar and battery abstraction to users and understand their cost benefits. In doing so, our comparison with a traditional community-owned system shows that our AutoShare approach can achieve the same global savings of 43% while providing independent control of the virtual system. Further, we show that independent energy sharing through virtualization provides an additional 8% increase in savings to individual owners.
Financial Toxicity During Breast Cancer Treatment: A Qualitative Analysis to Inform Strategies for Mitigation
Authors: Gharzai Laila A. , Ryan Kerry A. , Szczygiel Lauren , Goold Susan , Smith Grace , Hawley Sarah , Pottow John , Jagsi Reshma 
Published: July 2021

PURPOSE: Financial toxicity from cancer treatment is a growing concern. Its impact on patients requires refining our understanding of this phenomenon. We sought to characterize patients' experiences of financial toxicity in the context of an established framework to identify knowledge gaps and strategies for mitigation. METHODS: Semistructured interviews with patients with breast cancer who received financial aid from a philanthropic organization during treatment were conducted from February to May 2020. Interviews were transcribed and coded until thematic saturation was reached, and findings were contextualized within an existing financial toxicity framework. RESULTS: Thirty-two patients were interviewed, of whom 58% were non-Hispanic White. The mean age was 46 years. Diagnoses ranged from ductal carcinoma in situ to metastatic breast cancer. Concordant with an established framework, we found that direct and indirect costs determined objective financial burden and subjective financial distress stemmed from psychosocial, behavioral, and material impact of diagnosis and treatment. We identified expectations as a novel theme affecting financial toxicity. We identified knowledge gaps in treatment expectations, provider conversations, identification of resources, and support-finding and offer strategies for mitigating financial toxicity on the basis of participant responses, such as leveraging support from decision aids and allied providers. CONCLUSION: This qualitative study confirms an existing framework for understanding financial toxicity and identifies treatment expectations as a novel theme affecting both objective financial burden and subjective financial distress. Four knowledge gaps are identified, and strategies for mitigating financial toxicity are offered. Mitigating patients' financial toxicity is an important unmet need in optimizing cancer treatment.
Fetal Cardiac Lipid Sensing Triggers an Early and Sex-related Metabolic Energy Switch in Intrauterine Growth Restriction
Authors: Maréchal Loïze , Sicotte Benoit , Caron Véronique , Brochu Michèle , Tremblay André 
Published: July 2021

Abstract

Context
Intrauterine growth restriction (IUGR) is an immediate outcome of an adverse womb environment, exposing newborns to developing cardiometabolic disorders later in life.

Objective
This study investigates the cardiac metabolic consequences and underlying mechanism of energy expenditure in developing fetuses under conditions of IUGR.

Methods
Using an animal model of IUGR characterized by uteroplacental vascular insufficiency, mitochondrial function, gene profiling, lipidomic analysis, and transcriptional assay were determined in fetal cardiac tissue and cardiomyocytes.

Results
IUGR fetuses exhibited an upregulation of key genes associated with fatty acid breakdown and β-oxidation (Acadvl, Acadl, Acaa2), and mitochondrial carnitine shuttle (Cpt1a, Cpt2), instigating a metabolic gene reprogramming in the heart. Induction of Ech1, Acox1, Acox3, Acsl1, and Pex11a indicated a coordinated interplay with peroxisomal β-oxidation and biogenesis mainly observed in females, suggesting sexual dimorphism in peroxisomal activation. Concurring with the sex-related changes, mitochondrial respiration rates were stronger in IUGR female fetal cardiomyocytes, accounting for enhanced adenosine 5′-triphosphate production. Mitochondrial biogenesis was induced in fetal hearts with elevated expression of Ppargc1a transcript specifically in IUGR females. Lipidomic analysis identified the accumulation of arachidonic, eicosapentaenoic, and docosapentaenoic polyunsaturated long-chain fatty acids (LCFAs) in IUGR fetal hearts, which leads to nuclear receptor peroxisome proliferator-activated receptor α (PPARα) transcriptional activation in cardiomyocytes. Also, the enrichment of H3K27ac chromatin marks to PPARα-responsive metabolic genes in IUGR fetal hearts outlines an epigenetic control in the early metabolic energy switch.

Conclusion
This study describes a premature and sex-related remodeling of cardiac metabolism in response to an unfavorable intrauterine environment, with specific LCFAs that may serve as predictive effectors leading to IUGR.
Synthesis of Flower-Like Structured Calcium Silicide and Its Application in the Preparation of Palladium-Loaded Catalyst
Authors: Kamegawa Takashi , Kawakami Shoki , Okamoto Misumi , Katsumi Ryoichi 
Published: July 2021

Abstract
A flower like structured CaSi2 (f-CaSi2) was successfully prepared by a simple treatment of bulk CaSi2 powder in aqueous NaOH solution. Small and highly dispersed Pd nanoparticles were formed on f-CaSi2 by using unique properties of CaSi2 and H2 reduction, which also worked as a heterogeneous catalyst.
Improving research impact: lessons from the infrastructure engagement excellence standards
Authors: Jones Kirsty , Bice Sara 
Published: July 2021

Background:The gap between research and practical implementation remains a major challenge for policymakers. Research co-creation, involving researchers co-designing and co-producing research with industry, government and civil society, can support improved end user uptake and better research implementation.
Aims and objectives:This Practice Paper introduces a process of research co-creation based in implementation science and integrated knowledge translation theories. It details the development of the Infrastructure Engagement Excellence Standards (IEE), a framework of 10 Standards defining the qualities of community engagement for optimal infrastructure planning and delivery. The paper details a research co-creation process applicable across a variety of industries and policy settings.
Key conclusions:The Practice Paper introduces a theory-based method for research co-production and discusses strengths and weaknesses of the co-creation approach used to develop the IEE Standards. Implementation science and integrated knowledge translation theory offer important insights to support more successful research co-design and co-production. Research that incorporates these theories is better positioned to achieve implementation. The creation of the IEE Standards offers one helpful example of how researchers, policymakers and practitioners can begin to close the research-implementation gap.
Seasonal bias in global ocean color observations
Authors: Bisson K. M. , Boss E. , Werdell P. J. , Ibrahim A. , Frouin R. , Behrenfeld M. J. 
Published: July 2021

In this study, we identify a seasonal bias in the ocean color
satellite-derived remote sensing reflectances (

R

r
s

(
λ
)
;

s
r

−
1

) at the ocean color validation site,
Marine Optical BuoY. The seasonal bias in

R

r
s

(
λ
)

is present to varying degrees in all
ocean color satellites examined, including the Visible Infrared
Imaging Radiometer Suite, Sea-Viewing Wide Field-of-View Sensor, and
Moderate Resolution Imaging Spectrometer. The relative bias in

R

r
s

has spectral dependence. Products
derived from

R

r
s

(
λ
)

are affected by the bias to varying
degrees, with particulate backscattering varying up to 50% over a
year, chlorophyll varying up to 25% over a year, and absorption from
phytoplankton or dissolved material varying by up to 15%. The
propagation of

R

r
s

(
λ
)

bias into derived products is
broadly confirmed on regional and global scales using Argo floats and
data from the cloud-aerosol lidar with orthogonal polarization
instrument aboard the cloud-aerosol lidar and infrared pathfinder
satellite. The artifactual seasonality in ocean color is prominent in
areas of low biomass (i.e., subtropical gyres) and is not easily
discerned in areas of high biomass. While we have eliminated several
candidates that could cause the biases in

R

r
s

(
λ
)

, there are still outstanding
questions regarding potential contributions from atmospheric
corrections. Specifically, we provide evidence that the aquatic
bidirectional reflectance distribution function may in part cause the
observed seasonal bias, but this does not preclude an additional
effect of the aerosol estimation. Our investigation highlights the
contributions that atmospheric correction schemes can make in
introducing biases in

R

r
s

(
λ
)

, and we recommend more simulations
to discern these influence

R

r
s

(
λ
)

biases. Community efforts are needed
to find the root cause of the seasonal bias because all past, present,
and future data are, or will be, affected until a solution
is implemented.
Evaluation of a community-based HIV test and start program in a conflict affected rural area of Yambio County, South Sudan
Authors: Ferreyra Cecilia , Moretó-Planas Laura , Wagbo Temessadouno Fara , Alonso Beatriz , Tut Buai , Achut Victoria , Eltom Mohamed , Aderie Endashaw M. , Descalzo-Jorro Vicente 
Published: July 2021

Background
Antiretroviral therapy (ART) coverage in South Sudan is around 10%. Access to HIV care in settings with low ART coverage or conflict affected is still low; innovative strategies are needed to increase access and ensure continuation of ART during instability. A pilot HIV test and start project was implemented in a conflict-affected area of South Sudan. In a retrospective analysis, we determined the feasibility and outcomes of this intervention.

Methods
Programme data from July 2015 to June 2018 was analysed. The project involved five mobile teams offering HIV counselling and testing (HCT) and same day ART initiation at community level. Baseline and follow-up information on clinical, immunological and viral load (VL) was routinely recorded, as well as treatment outcomes. A semi-qualitative study was conducted to assess acceptability of the program among beneficiaries and community members.

Results
By June 2018, 14824 people received counselling and testing for HIV and 498 (3.4%) tested positive. Out of those 395 (79.3%) started ART. A total of 72 ART patients were organized in 26 Community ART Groups (CAGs) and contingency plan was activated 9 times for 101 patients. Kaplan-Meier estimated retention in care (RIC) at 12 and 18 months was 80.6% [95% CI: 75.9–84.5%] and 69.9% [95% CI: 64.4–74.8%] respectively. RIC was significantly higher at 18 months in patients under community ART groups (CAGs) (90.9% versus 63.4% p<0.001) when compared to patients on regular follow up. VL suppression at 12 months was 90.3% and overall virological suppression reached 91.2%. A total of 279 persons were interviewed about the MSF program perception and acceptance: 98% had heard about the programme and 84% found it beneficial for the community, 98% accepted to be tested and only 4% found disadvantages to the programme.

Conclusions
Our study shows that HCT and early ART initiation in conflict affected populations can be provided with good program outcomes. RIC and virological suppression are comparable with facility-based HIV programs and to those in stable contexts. This model could be extrapolated to other similar contexts with low access to ART and where security situation is a concern.
Rancang Bangun Aplikasi Tele-Kendali Komputer Via Jaringan PSTN dengan Modul DTMF dan Mikrokontroller Attiny2313
Authors: Erdani Yuliardi , Rudiansyah Hendy 
Published: July 2021

Extremely long distance control, hardly reachable actuator/target and costly network development are some concerns within a distance control system. Such control is computer control for advertisements placed in tricky areas as locations over the bridge, at a junction, etc. The provider usually performs system inactivation in order to save energy. But until now, it is still difficult to find a system that can be turned on and off in remote manner. That is why the distant control using telephone can be the best alternative solution. Not only can the telephone be used in wide range of area, but also easily operated. The developed circuit in this research uses dual tone multiple frequency (DTMF). It is operated by pressing telephone button as control input for microcontroller. The microcontroller processes the input and controls the computer via relay and serial port. The result of experiment shows that the developed application is able to shut down and turn on computer as well as to apply software remotely.
INTENSI KELUAR KERJA DITINJAU DARI THEORY OF PLANNED BEHAVIOR
Authors: Titiani Skolastika Meta Wedika , Rostiana Rostiana 
Published: July 2021

This study aimed to explore the formation process of employees’ intentions to leave viewed by Planned Behavior Theory during the Covid-19 Pandemic and to determine the factors that influence the formation of employees’ intentions to leave. The intention to leave work is how much encouragement an employee has to leave the company. Based on theory of planned behavior, intention was formed by indirect belief factor and direct belief factor. The components of indirect belief were behavioral belief, normative belief, and control belief. The components of direct belief were attitudes toward behavior, subjective norms, and perceived behavioral control. The research method used was mixed method design. This research consisted of 2 stages research. First study (study 1) aimed to determine the subject's understanding toward components of indirect belief that contributed to form intention. Second study (study 2) aimed to test the measurement model through Confirmatory Factor Analysis (CFA) and structural model theory of planned behavior in the form of a Goodness of Fit test. The measurement used was the ‘Lisrel’ program. The results showed that work leave intentions were influenced by attitudes toward behavior, subjective norms and behavior control. The dominant predictor of intention to leave was subjective norms. Penelitian ini bertujuan untuk mengetahui proses terbentuknya intensi keluar kerja ditinjau dari theory of planned behavior di masa pandemi Covid-19 dan mengetahui faktor yang mempengaruhi intensi karyawan keluar kerja. Intensi keluar kerja adalah dorongan yang dimiliki seseorang untuk keluar dari perusahaan. Menurut theory of planned behavior, intensi dipengaruhi oleh faktor keyakinan tidak langsung dan faktor keyakinan langsung. Komponen dalam keyakinan tidak langsung meliputi: keyakinan perilaku, keyakinan normatif, dan keyakinan kontrol. Komponen dalam keyakinan langsung meliputi: sikap terhadap perilaku, norma subjektif, dan kontrol perilaku. Metode penelitian yang digunakan adalah metode campuran. Penelitian ini terdiri dari 2 tahap. Tahap pertama (studi 1) bertujuan untuk menggali komponen-komponen pada keyakinan tidak langsung yang berperan dalam pembentukan intensi. Tahap kedua (studi 2) bertujuan untuk menguji model pengukuran melalui Confirmatory Factor Analysis (CFA) dan uji model struktural theory of planned behavior berupa uji kecocokan model (Goodness of Fit). Pengukuran yang digunakan menggunakan program Lisrel. Hasil penelitian menunjukkan bahwa intensi kerja dipengaruhi oleh sikap terhadap perilaku, norma subjektif dan kontrol perilaku. Faktor yang paling dominan dalam mempengaruhi intensi keluar kerja adalah norma subjektif.
Ética do Slow Cinema: Lentidão e hesitação no cinema contemporâneo
Authors: Brandão Pinto Eduardo 
Published: July 2021

Recentemente, teóricos e críticos cinematográficos observaram o aparecimento, nas últimas três décadas, de um “cinema de lentidão”. O conceito de Slow Cinema é recuperado neste artigo, buscando possíveis conexões históricas e culturais com outras experiências de desaceleração do tempo. Categorias como flâneur (Benjamin), o blasé (Simmel) e o pensamento sobre a hesitação, na filosofia de Bergson, já apontavam para a descompressão da duração do intervalo entre estímulo e resposta. O conceito de imagem-tempo (Deleuze) auxilia-nos a explorar o surgimento de uma ética da lentidão no cinema moderno. Por fim, analisando filmes de Wim Wenders, Abbas Kiarostami e Cristi Puiu, sugerimos que o Slow Cinema investe numa temporalização das passagens de causa e efeito como modo de produção de uma situação favorável à reconexão entre sujeito e mundo.
Die Bewältigung der Corona-Pandemie durch das Team der Hochschulbibliothek Ludwigshafen/Rhein
Authors: Oh Guido , Haß Torsten 
Published: July 2021

Zusammenfassung
Die coronabedingten Erlebnisse und Vorgänge in der Hochschulbibliothek Ludwigshafen waren eine nie dagewesene Ausnahmesituation für alle Beteiligten. Die Herausforderungen für einen reibungslosen und vor allem sicheren Ablauf vor und hinter den Kulissen stellten das Bibliotheksteam vor großen Herausforderungen, die letztlich souverän gemeistert und seitens der Hochschulleitung und der Studierendenschaft anerkennend gewürdigt wurde. Dieser Bericht versucht mit Stand 29.04.2021 Verlauf und Entwicklungen der Corona-Situation chronologisch einzuordnen und einen Einblick zu geben in die Ereignisse und Problemstellungen im Betrieb, im Alltagsgeschäft und im Homeoffice.
Preparation of cypress (Cupressus sempervirens L.) essential oil loaded poly(lactic acid) nanofibers
Authors: Argui Hayfa , Suner Salih Can , Periz Çağdaş Deniz , Ulusoy Seyhan , Türker Gülen , Ben-Attia Mossadok , Büyükkaya Fikret , Oral Ayhan , Coşkun Yalçın , Said Hechmi 
Published: July 2021

Abstract
This study investigated the production of poly(lactic acid) (PLA) nanofibers containing cypress (CUP) essential oil (EO) via electrospinning. The nanofibers were produced from polymer solution prepared with different percentages of cypress EO. Cypress EO-containing PLA nanofibers were characterized and some mechanical and thermal properties were examined using thermogravimetric analysis, scanning electron microscopy, Fourier-transform infrared spectroscopy, and dynamic mechanical analysis. The thermal stability of the nanofibers was reduced depending on the percentage of the cypress EO. As the ratio of the cypress EO to polymer matrices was increased, it was observed that the glassy transition temperatures of the nanofibers decreased and their flexibility increased. The T
g value was determined to be 53.74°C for the neat PLA nanofiber, while 51.83°C for the PLA-CUP nanofiber (containing 15% cypress EO). According to the results of releasing trial, the increased amount of cypress EO resulted in less cypress EO releasing from polymer matrices. The nanofibers were observed to exhibit antibacterial activity against Escherichia coli and Staphylococcus aureus. The inhibition zone diameter of the nanofibers containing 10% cypress EO was 20 mm for S. aureus and 16 mm for E. coli, while 10 mm in the presence of Kanamycin.