bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions of Risk: Perspectives on Crime and Safety in Public Housing for Older Adults
Authors: Sheppard Christine L , Gould Sarah , Austen Andrea , Hitzig Sander L 
Published: October 2021

Abstract

Background and Objectives
An increasing number of older adults are aging in place in public housing. Public housing is perceived to have higher rates of crime that have detrimental impacts on health and well-being. We used a qualitative approach to understand the experiences of safety and unsafety for older adults in public housing.

Research Design and Methods
Participants included older adult tenants (n = 58) as well as service providers (n = 58) who offer supports directly in the buildings. Semistructured qualitative interviews and focus groups were used to explore (a) what makes the buildings feel unsafe, (b) how safety concerns affect access to support services, and (c) strategies used to promote safety.

Results
Participants acknowledged the importance of safety for creating a home-like environment; however, many described feeling unsafe at home or work. Participants described extreme examples of antisocial behaviors that were pervasive and viewed as commonplace. Lack of building security was a key issue, which was compounded by a perceived lack of accountability. While service providers were willing to accept a certain level of risk, many acknowledged that unsafe situations forced them to withdraw in-home services or stop community programs, further contributing to feelings of unsafety. In the absence of effective formal security, participants described several measures taken to mitigate risk.

Discussion and Implications
Our findings point to the need for enhanced physical and environmental safety infrastructure, improved building management, increased on-site security, as well as other proactive measures to reduce risk by creating a greater sense of connection and community within the buildings.
Epidemiology of Inflammatory Bowel Diseases in Israel: A Nationwide Epi-Israeli IBD Research Nucleus Study
Authors: Stulman Mira Y , Asayag Noa , Focht Gili , Brufman Ilan , Cahan Amos , Ledderman Natan , Matz Eran , Chowers Yehuda , Eliakim Rami , Ben-Horin Shomron , Odes Shmuel , Dotan Iris , Balicer Ran D , Benchimol Eric I , Turner Dan 
Published: October 2021

Abstract

Background
There are currently no nationwide data on the epidemiology of inflammatory bowel diseases (IBD) in Israel. We aimed to determine the population-based epidemiological trends of IBD in the diverse Israeli population.

Methods
Health-administrative data were retrieved from all 4 Israeli health maintenance organizations, insuring 98% of the population, using validated identification algorithms. National trends were determined using Joinpoint regression analysis calculating annual percent change and average annual percent change (AAPC).

Results
By 2019, there were 46,074 patients with IBD in Israel, corresponding to a national prevalence of 519/100,000 (0.52%), of whom 54.1% had Crohn disease (CD) and 45.9% had ulcerative colitis (UC). The number of Jewish patients doubled from 18,701 in 2005 (354/100,000) to 38,950 (589/100,000) in 2018 (AAPC, +4.0%; P &lt; 0.05), and the number of Arab patients increased 3-fold from 1096 (102.1/100,000) to 3534 (240.7/100,000; AAPC, +6.8%; P &lt; 0.05) during the same years. However, the increase rate has gradually decelerated over time (annual percent change during 2005-2008, 2009-2014, and 2005-2018 was +6.7%, +4.2%, and +2.3%, respectively; P &lt; 0.05). Pediatric prevalence increased from 37.4 to 52.2/100,000, with CD predominating in both Jews and Arabs. The incidence of CD remained stable (from 15.9/100,000 to 14.9/100,000) and the incidence of UC decreased (15.4/100,000 to 10.5/100,000 (AAPC, –3.2%; P &lt; 0.001)). In contrast, pediatric incidence of CD increased from 7.3/100,000 to 8.3/100,000 (AAPC, +1.9%; P &lt; 0.05) and that of UC increased from 2.6 to 4.4/100,000 (AAPC, +5.8%; P &lt; 0.05).

Conclusions
The IBD prevalence rate in Israel is still increasing but gradually decelerating, probably due to the decreasing overall IBD incidence. Nonetheless, incidence rate in children is still increasing. Ongoing narrowing in the rates between Jews and Arabs over time may indicate shared environmental factors.
Incidence and management of the left ventricular outflow obstruction in patients with atrioventricular septal defects
Authors: Ivanov Yaroslav , Buratto Edward , Naimo Phillip , Lui Adrienne , Hu Thomas , d’Udekem Yves , Brizard Christian P , Konstantinov Igor E 
Published: October 2021

Abstract

OBJECTIVES
Left ventricular outflow tract obstruction (LVOTO) is a recognized complication after complete repair of atrioventricular septal defect (AVSD). This study reviewed the incidence and management of LVOTO following AVSD repair at a single institution.

METHODS
From 1975 to 2019, 24 patients (3.3%, 24/730) underwent reoperation due to LVOTO following partial AVSD (pAVSD) and complete AVSD (cAVSD) repair. The data were retrospectively reviewed.

RESULTS
The incidence of LVOTO following pAVSD and cAVSD repair was 4.4% (12/275) and 2.6% (12/455). Freedom from LVOTO reoperation following pAVSD and cAVSD repair at 25 years was 94.3% [95% confidence interval (CI); 89.7–96.7] and 95% (95% CI; 91.1–97.3). The median time from complete repair of pAVSD and cAVSD to LVOTO reoperation was 4.4 years [interquartile range (IQR): 3.4–6.7] and 2.6 years (IQR: 2.2–4.7). Freedom from second LVOTO reoperation at 5, 10 and 15 years was 83.7% (95% CI; 57.2–98.2), 59.2% (95% CI; 28.7, 80.3) and 39.5% (95% CI; 13.2–65.3). The median time between the first and the second LVOTO reoperation in the groups of pAVSD and cAVSD was 6.1 years (IQR: 3.4–8.9) and 8.6 years (IQR: 5.7–9.8). There was no significant difference regarding the first (P = 0.7406) and subsequent LVOTO (P = 0.7153) following complete repair of pAVSD and cAVSD. Combined access to the left ventricular outflow tract was not protective regarding LVOTO reoccurrence. Survival for both groups after LVOTO reoperation at 15 years was 95.6% (95% CI 99.4–72.9).

CONCLUSIONS
Incidence of LVOTO after AVSD repair is low but the reoccurrence rate is high. Standard subaortic resection does not always provide definitive LVOTO relief. The survival after LVOTO reoperation is excellent.
Cash Transfers, Negative Rainfall Shocks and Child Welfare in Ethiopia
Authors: Haile Kaleab 
Published: October 2021

Abstract
This study examines the role of cash transfers in mitigating the welfare impact of negative rainfall shocks on children in rural households. Household-level panel data, obtained from areas where Ethiopia’s Social Cash Transfer Pilot Programme operated, are merged with available climate data. The results from a two-way fixed effects model reveal that cash transfers significantly reduce the negative effect of drought on food consumption Z-score of children in beneficiary households. As the magnitude of drought increases, however, no difference in children’s FCS Z-score is found between beneficiary and non-beneficiary households. The study provides evidence for household food consumption-based coping strategies as a mechanism. As such, beneficiary households are able to avoid food consumption-destabilising coping strategies as long as the droughts they experience are not of high magnitude. The findings of this study offer policy-relevant insights into the extent to which cash transfers can buffer the adverse welfare impact of drought on children.
Chemical composition, energy content and amino acid digestibility in cyperus esculentus co-products fed to growing pigs
Authors: Wang Lu , Zhou Junyan , Chen Yifan , Wang Li , Pan Hongmei , Hu Qile , Shi Huangwei , Lai Changhua 
Published: October 2021

Abstract
This study was conducted to determine the chemical composition, DE, ME and NE contents, and the apparent and standardized ileal digestibility (AID and SID) of AA in cyperus esculentus co-products fed to growing pigs. The 5 cyperus esculentus co-products included expeller-pressed cyperus esculentus cake (EPCC), cold-pressed cyperus esculentus cake (CPCC), solvent-extracted cyperus esculentus meal (SECM), cyperus esculentus distillers’s dried grains with solubles (CE DDGS) and cyperus esculentus meal (CEM). In Exp. 1, a total of 36 crossbred growing pigs (Duroc × Landrace × Yorkshire; BW: 50.12 ± 2.91 kg) were fed 1 of 6 diets in a completely randomized design. The diets included a corn-soybean meal basal diet and 5 experimental diets containing 24.31% cyperus esculentus co-products. In Exp. 2, 12 same breed of growing pigs (BW: 47.12 ± 3.2 kg), surgically fitted with a T-cannula in the distal ileum, were allotted to 1 of 4 experimental diets in a 2-period Youden Square design. The diets included 1 N-free diet and 3 experimental diets containing 50% cyperus esculentus co-products (including EPCC, SECM and CE DDGS). Results indicated that the SECM and CE DDGS had the greatest contents of starch and CP, respectively. The contents of CF, NDF and ADF were the greatest in CEM and the lowest in SECM. On a DM basis, the DE, ME, predicted NE and apparent total tract digestibility (ATTD) of GE values of the 5 cyperus esculentus co-products ranged from 1,203 to 3,897 kcal/kg, 1,127 to 3,621 kcal/kg, 536 to 2,871 kcal/kg and 28% to 79%, respectively. The EPCC and CPCC had the greatest DE, ME and predicted NE values and CPCC, EPCC and SECM had the greatest ATTD of GE, whereas CEM had the lowest DE, ME, NE and ATTD of GE (P &lt; 0.001). The NDF and ADF were negatively correlated with DE, ME and NE (P &lt; 0.05). The AID and SID of CP varied from 53.57 % to 57.86% and from 69.99% to 87.85%, respectively. The EPCC and SECM had greater SID of CP, Ile, Met, Val, Asp, Cys and Tyr compared to those of CE DDGS (P &lt; 0.05). These results indicated that the chemical composition, DE, ME and NE as well as the most AA digestibility of cyperus esculentus co-products obtained from different processing techniques varied greatly. Based on the energy contents and AA digestibility, the EPCC is a better feedstuff for growing pigs compared with the other 4 cyperus esculentus co-products.
Genetic variability in the feeding behavior of crossbred growing cattle and associations with performance and feed efficiency
Authors: Kelly David N , Sleator Roy D , Murphy Craig P , Conroy Stephen B , Berry Donagh P 
Published: October 2021

Abstract
The objectives of the present study were to estimate genetic parameters for several feeding behavior traits in growing cattle, as well as the genetic associations among and between feeding behavior and both performance and feed efficiency traits. An additional objective was to investigate the use of feeding behavior traits as predictors of genetic merit for feed intake. Feed intake and live-weight data on 6,088 growing cattle were used of which 4,672 had ultrasound data and 1,548 had feeding behavior data. Feeding behavior traits were defined based on individual feed events or meal events (where individual feed events were grouped into meals). Univariate and bivariate animal linear mixed models were used to estimate (co)variance components. Heritability estimates (± SE) for the feeding behavior traits ranged from 0.19 ± 0.08 for meals per day to 0.61 ± 0.10 for feeding time per day. The coefficient of genetic variation per trait varied from 5% for meals per day to 22% for the duration of each feed event. Genetically heavier cattle, those with a higher daily energy intake (MEI), or those that grew faster had a faster feeding rate, as well as a greater energy intake per feed event and per meal. Better daily feed efficiency (i.e., lower residual energy intake) was genetically associated with both a shorter feeding time per day and shorter meal time per day. In a validation population of 321 steers and heifers, the ability of estimated breeding values (EBV) for MEI to predict (adjusted) phenotypic MEI was demonstrated; EBVs for MEI were estimated using multi-trait models with different sets of predictor traits such as liveweight and/or feeding behaviors. The correlation (± SE) between phenotypic MEI and EBV for MEI marginally improved (P &lt; 0.001) from 0.64 ± 0.03 to 0.68 ± 0.03 when feeding behavior phenotypes from the validation population were included in a genetic evaluation that already included phenotypic mid-test metabolic live-weight from the validation population. This is one of the largest studies demonstrating that significant exploitable genetic variation exists in the feeding behavior of young crossbred growing cattle; such feeding behavior traits are also genetically correlated with several performance and feed efficiency metrics. Nonetheless, there was only a marginal benefit to the inclusion of time-related feeding behavior phenotypes in a genetic evaluation for MEI to improve the precision of the EBVs for this trait.
Genome-wide distribution of 5hmC in the dental pulp of mouse molars and incisors
Authors: Joshi Pujan , Vijaykumar Anushree , Enkhmandakh Badam , Mina Mina , Shin Dong-Guk , Bayarsaihan Dashzeveg 
Published: October 2021

Abstract
The dental pulp is critical for the production of odontoblasts to create reparative dentin. In recent years, dental pulp has become a promising source of mesenchymal stem cells that are capable of differentiating into multiple cell types. To elucidate the transcriptional control mechanisms specifying the early phases of odontoblast differentiation, we analysed the DNA demethylation pattern associated with 5-hydroxymethylcytosine (5hmC) in the primary murine dental pulp. 5hmC plays an important role in chromatin accessibility and transcriptional control by modelling a dynamic equilibrium between DNA methylation and demethylation. Our research revealed 5hmC enrichment along genes and non-coding regulatory regions associated with specific developmental pathways in the genome of mouse incisor and molar dental pulp. Although the overall distribution of 5hmC is similar, the intensity and location of the 5hmC peaks significantly differs between the incisor and molar pulp genome, indicating cell type-specific epigenetic variations. Our study suggests that the differential DNA demethylation pattern could account for the distinct regulatory mechanisms underlying the tooth-specific ontogenetic programs.
The Intergenerational Effect of Fundamental Rights: A Contribution of the German Federal Constitutional Court to Climate Protection
Authors: Winter Gerd 
Published: October 2021

Abstract
By a recent judgment, the German Federal Constitutional Court enhanced the concept of fundamental rights to climate protection in three dimensions: their number, content and temporal reach. While previously fundamental rights to health, occupation and property have been trialled in domestic climate litigation, the Court here propounds almost all fundamental rights to being inflicted insofar as their enjoyment hinges upon the availability of fossil energy and thus the emission of greenhouse gases. Developing an intertemporal dimension of those rights, the Court finds an imbalance of permissible greenhouse gas emissions in that most of the emission budget available within a temperature increase of well below 2°C will be spent by 2030, leaving only a minimum use of fossil fuels for subsequent years and generations. This analysis summarises the Court’s legal reasoning, positioning it in the broader spectrum of fundamental rights doctrine, and reflects on the contribution of the case to the growing number of transnational climate jurisprudence.
A Study of Cuticular Hydrocarbons of All Life Stages in Sarcophaga peregrina (Diptera: Sarcophagidae)
Authors: Zhang Xiangyan , Shang Yanjie , Ren Lipin , Qu Hongke , Zhu Guanghui , Guo Yadong 
Published: October 2021

Abstract
Sarcophaga peregrina (Robineau-Desvoidy, 1830), a synanthropic flesh fly species found in different parts of the world, is of medical and forensic importance. Traditional methods of inferring developmental age rely on the life stage of insects and morphological changes. However, once the larvae reach the pupal and adult stage, morphological changes would become barely visible, so that the classic method would be invalid. Here, we studied the cuticular hydrocarbon profile of S. peregrina of the whole life cycle from larval stage to adult stage by GC–MS. Sixty-three compounds with carbon chain length ranging from 8 to 36 were detected, which could be categorized into four classes: n-alkanes, branched alkanes, alkenes, and unknowns. As developmental increased, branched alkanes dominant, and the content of high-molecular-weight hydrocarbons is variable, especially for 2-methyl C19, DiMethyl C21, docosane (C22), and tricosane (C23). This study shows that the composition of CHC could be used to determine the developmental age of S. peregrina and aid in postmortem interval estimations in forensic science.
Accurate line strengths, transition rates and lifetimes of 2s2p2(4P)3s in N II
Authors: Wang Huaying , Wang Chenming , Shen Xiaozhi , Chen Zhanbin , Li Xiangfu , Zhang Xueyang 
Published: October 2021

Abstract
The accurate line strengths, transition rates, oscillator strengths, and lifetimes from the inner-shell 2s2p2(4P)3s states 5P and 3P of N II are reported within the framework of the multiconfiguration Dirac-Hartree-Fock (MCDHF) method. The effects of core-core, core-valence, and valence correlations; the Breit interaction; and QED effect are taken into account. Through investigating the influences of electron correlation effects on the quintet states, it is found that the core correlation effect has certain compensation effect in accurately optimizing the line strengths, transition rates and lifetimes of quintet states; the branching fractions of 2s2p3 5S$^\circ _{2}$–2s2p2(4P)3s 5P1, 2, 3 tend to 1, which is inferred as a peculiar intrinsic property that can be useful for plasma diagnostics; unlike 3P0, 1, 2 and 5P1, 3, the calculations of lifetime of 5P2 show some J-dependence, and the velocity form calculations for this J=2-dependence are much more sensitive to electron correlations of 1s22s2p2(4P)3l (l = p, d) than those in the length gauge, which will be helpful to deal with the calculations of lifetime with J=2-dependence in the carbon like isoelectronic series.
Lower Statistical Support with Larger Data Sets: Insights from the Ochrophyta Radiation
Authors: Di Franco Arnaud , Baurain Denis , Glöckner Gernot , Melkonian Michael , Philippe Hervé 
Published: October 2021

Abstract
It is commonly assumed that increasing the number of characters has the potential to resolve evolutionary radiations. Here, we studied photosynthetic stramenopiles (Ochrophyta) using alignments of heterogeneous origin mitochondrion, plastid, and nucleus. Surprisingly while statistical support for the relationships between the six major Ochrophyta lineages increases when comparing the mitochondrion (6,762 sites) and plastid (21,692 sites) trees, it decreases in the nuclear (209,105 sites) tree. Statistical support is not simply related to the data set size but also to the quantity of phylogenetic signal available at each position and our ability to extract it. Here, we show that this ability for current phylogenetic methods is limited, because conflicting results were obtained when varying taxon sampling. Even though the use of a better fitting model improved signal extraction and reduced the observed conflicts, the plastid data set provided higher statistical support for the ochrophyte radiation than the larger nucleus data set. We propose that the higher support observed in the plastid tree is due to an acceleration of the evolutionary rate in one short deep internal branch, implying that more phylogenetic signal per position is available to resolve the Ochrophyta radiation in the plastid than in the nuclear data set. Our work therefore suggests that, in order to resolve radiations, beyond the obvious use of data sets with more positions, we need to continue developing models of sequence evolution that better extract the phylogenetic signal and design methods to search for genes/characters that contain more signal specifically for short internal branches.
A Mutation–Selection Model of Protein Evolution under Persistent Positive Selection
Authors: Tamuri Asif U , dos Reis Mario 
Published: October 2021

AbstractWe use first principles of population genetics to model the evolution of proteins under persistent positive selection (PPS). PPS may occur when organisms are subjected to persistent environmental change, during adaptive radiations, or in host–pathogen interactions. Our mutation–selection model indicates protein evolution under PPS is an irreversible Markov process, and thus proteins under PPS show a strongly asymmetrical distribution of selection coefficients among amino acid substitutions. Our model shows the criteria ω&gt;1 (where ω is the ratio of nonsynonymous over synonymous codon substitution rates) to detect positive selection is conservative and indeed arbitrary, because in real proteins many mutations are highly deleterious and are removed by selection even at positively selected sites. We use a penalized-likelihood implementation of the PPS model to successfully detect PPS in plant RuBisCO and influenza HA proteins. By directly estimating selection coefficients at protein sites, our inference procedure bypasses the need for using ω as a surrogate measure of selection and improves our ability to detect molecular adaptation in proteins.
exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids
Authors: Lai Hongyan , Li Yuchen , Zhang Hena , Hu Jia , Liao Jiatao , Su Ying , Li Qin , Chen Bing , Li Caiping , Wang Zhen , Li Yan , Wang Jialei , Meng Zhiqiang , Huang Zhaohui , Huang Shenglin 
Published: October 2021

Abstract
Extracellular vesicles (EVs) are small membranous vesicles that contain an abundant cargo of different RNA species with specialized functions and clinical implications. Here, we introduce an updated online database (http://www.exoRBase.org), exoRBase 2.0, which is a repository of EV long RNAs (termed exLRs) derived from RNA-seq data analyses of diverse human body fluids. In exoRBase 2.0, the number of exLRs has increased to 19 643 messenger RNAs (mRNAs), 15 645 long non-coding RNAs (lncRNAs) and 79 084 circular RNAs (circRNAs) obtained from ∼1000 human blood, urine, cerebrospinal fluid (CSF) and bile samples. Importantly, exoRBase 2.0 not only integrates and compares exLR expression profiles but also visualizes the pathway-level functional changes and the heterogeneity of origins of circulating EVs in the context of different physiological and pathological conditions. Our database provides an attractive platform for the identification of novel exLR signatures from human biofluids that will aid in the discovery of new circulating biomarkers to improve disease diagnosis and therapy.