bluuebunny/crossref_metadata_2025_split huggingface dataset:
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Authors: Reynolds Joseph C. , Lai Rochelle W. , Woodhead Jonathan S. T. , Joly James H. , Mitchell Cameron J. , Cameron-Smith David , Lu Ryan , Cohen Pinchas , Graham Nicholas A. , Benayoun Bérénice A. , Merry Troy L. , Lee Changhan 
Published: January 2021

AbstractHealthy aging can be promoted by enhanced metabolic fitness and physical capacity. Mitochondria are chief metabolic organelles with strong implications in aging that also coordinate broad physiological functions, in part, using peptides that are encoded within their independent genome. However, mitochondrial-encoded factors that actively regulate aging are unknown. Here, we report that mitochondrial-encoded MOTS-c can significantly enhance physical performance in young (2 mo.), middle-age (12 mo.), and old (22 mo.) mice. MOTS-c can regulate (i) nuclear genes, including those related to metabolism and proteostasis, (ii) skeletal muscle metabolism, and (iii) myoblast adaptation to metabolic stress. We provide evidence that late-life (23.5 mo.) initiated intermittent MOTS-c treatment (3x/week) can increase physical capacity and healthspan in mice. In humans, exercise induces endogenous MOTS-c expression in skeletal muscle and in circulation. Our data indicate that aging is regulated by genes encoded in both of our co-evolved mitochondrial and nuclear genomes.
The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells
Authors: Sharma Rajiv , Dever Daniel P. , Lee Ciaran M. , Azizi Armon , Pan Yidan , Camarena Joab , Köhnke Thomas , Bao Gang , Porteus Matthew H. , Majeti Ravindra 
Published: January 2021

AbstractTargeted DNA correction of disease-causing mutations in hematopoietic stem and progenitor cells (HSPCs) may enable the treatment of genetic diseases of the blood and immune system. It is now possible to correct mutations at high frequencies in HSPCs by combining CRISPR/Cas9 with homologous DNA donors. Because of the precision of gene correction, these approaches preclude clonal tracking of gene-targeted HSPCs. Here, we describe Tracking Recombination Alleles in Clonal Engraftment using sequencing (TRACE-Seq), a methodology that utilizes barcoded AAV6 donor template libraries, carrying in-frame silent mutations or semi-randomized nucleotides outside the coding region, to track the in vivo lineage contribution of gene-targeted HSPC clones. By targeting the HBB gene with an AAV6 donor template library consisting of ~20,000 possible unique exon 1 in-frame silent mutations, we track the hematopoietic reconstitution of HBB targeted myeloid-skewed, lymphoid-skewed, and balanced multi-lineage repopulating human HSPC clones in mice. We anticipate this methodology could potentially be used for HSPC clonal tracking of Cas9 RNP and AAV6-mediated gene targeting outcomes in translational and basic research settings.
Observation of anti-parity-time-symmetry, phase transitions and exceptional points in an optical fibre
Authors: Bergman Arik , Duggan Robert , Sharma Kavita , Tur Moshe , Zadok Avi , Alù Andrea 
Published: January 2021

AbstractThe exotic physics emerging in non-Hermitian systems with balanced distributions of gain and loss has recently drawn a great deal of attention. These systems exhibit phase transitions and exceptional point singularities in their spectra, at which eigen-values and eigen-modes coalesce and the overall dimensionality is reduced. So far, these principles have been implemented at the expense of precise fabrication and tuning requirements, involving tailored nano-structured devices with controlled optical gain and loss. In this work, anti-parity-time symmetric phase transitions and exceptional point singularities are demonstrated in a single strand of single-mode telecommunication fibre, using a setup consisting of off-the-shelf components. Two propagating signals are amplified and coupled through stimulated Brillouin scattering, enabling exquisite control over the interaction-governing non-Hermitian parameters. Singular response to small-scale variations and topological features arising around the exceptional point are experimentally demonstrated with large precision, enabling robustly enhanced response to changes in Brillouin frequency shift.
Functional traits of the world’s late Quaternary large-bodied avian and mammalian herbivores
Authors: Lundgren Erick J. , Schowanek Simon D. , Rowan John , Middleton Owen , Pedersen Rasmus Ø. , Wallach Arian D. , Ramp Daniel , Davis Matt , Sandom Christopher J. , Svenning Jens-Christian 
Published: January 2021

AbstractPrehistoric and recent extinctions of large-bodied terrestrial herbivores had significant and lasting impacts on Earth’s ecosystems due to the loss of their distinct trait combinations. The world’s surviving large-bodied avian and mammalian herbivores remain among the most threatened taxa. As such, a greater understanding of the ecological impacts of large herbivore losses is increasingly important. However, comprehensive and ecologically-relevant trait datasets for extinct and extant herbivores are lacking. Here, we presentHerbiTraits, a comprehensive functional trait dataset for all late Quaternary terrestrial avian and mammalian herbivores ≥10 kg (545 species).HerbiTraitsincludes key traits that influence how herbivores interact with ecosystems, namely body mass, diet, fermentation type, habitat use, and limb morphology. Trait data were compiled from 557 sources and comprise the best available knowledge on late Quaternary large-bodied herbivores.HerbiTraitsprovides a tool for the analysis of herbivore functional diversity both past and present and its effects on Earth’s ecosystems.
Research on Golay-coded excitation in real-time imaging of high frequency ultrasound biomicroscopy
Authors: Wang Xiaochun , Yang Jun , Ji Jianjun , Zhang Yusheng , Zhou Sheng 
Published: January 2021

AbstractHigh frequency ultrasonic imaging provides clinicians with high-resolution diagnostic images and more accurate measurement results. The technique is now widely used in ophthalmology, dermatology, and small animal imaging. However, since ultrasonic attenuation in tissue increases rapidly with increasing frequency, the depth of detection of high frequency ultrasound in tissue is limited to a few millimeters. In this paper, a novel method of using Golay-coded excitation as a replacement for conventional single-pulse excitation in high frequency ultrasound biomicroscopy was proposed, and real-time imaging was realized. While maintaining the transmission voltage and image resolution unchanged, the detection depth can be effectively improved. The ultrasonic transmission frequency is 30 MHz and the transmission voltage is ± 60 V p-p. In this study, 4-bit, 8-bit, and 16-bit coding sequences and decoding compression were used. To verify the effectiveness of the coding sequence in real-time imaging of ultrasound biomicroscopy, we designed a 10-μm diameter line target echo experiment, an ultrasound phantom experiment, and an in vitro porcine eye experiment. The experimental results show that the code/decode method of signal processing can not only maintain a resolution consistent with that of single-pulse transmission, but can also improve the detection depth and signal-to-noise ratio.
Exceptional ground motion during the shallow Mw 4.9 2019 Le Teil earthquake, France
Authors: Causse Mathieu , Cornou Cécile , Maufroy Emeline , Grasso Jean-Robert , Baillet Laurent , El Haber Elias 
Published: January 2021

AbstractAn unusually damaging Mw 4.9 earthquake occurred on November 11, 2019 in the south east of France within the lower Rhône river valley, an industrial region that hosts several operating nuclear power plants. The hypocentre of this event occurred at an exceptionally shallow depth of about 1 km. Here we use far-field seismological observations to demonstrate that the rupture properties are consistent with those commonly observed for large deeper earthquakes. In the absence of strong motion sensors in the fault vicinity, we perform numerical predictions of the ground acceleration on a virtual array of near-fault stations. These predictions are in agreement with independent quantitative estimations of ground acceleration from in-situ observations of displaced objects. Both numerical and in-situ analyses converge toward estimates of an exceptional level of ground acceleration in the fault vicinity, that locally exceeded gravity, and explain the unexpectedly significant damage.
Orofacial Myofunctional Therapy and Myofunctional Devices Used in Speech Pathology Treatment: A Systematic Quantitative Review of the Literature
Authors: Shortland Hollie-Ann L. , Hewat Sally , Vertigan Anne , Webb Gwendalyn 
Published: January 2021

PurposeA growing number of speech-language pathologists (SLPs) are using orofacial myofunctional therapy (OMT) and/or myofunctional devices (MDs) in the treatment of their clients. However, governing bodies suggest SLPs carefully consider the availability and quality of evidence in the utilization of these therapies in speech-language pathology treatment. The purpose of this study was to review the existing evidence for OMT and MDs used by SLPs.MethodA systematic quantitative review was conducted using key search terms in three electronic platforms housing multiple databases, along with a hand search, to identify additional literature. All studies published in English in full text were included if they reported pre- and posttreatment data of OMT and/or MDs provided by an SLP. Data were extracted and analyzed by the first author and confirmed by the co-authors.ResultsTwenty-eight studies met the criteria for inclusion in the review. Two thirds were published in the last decade and involved the use of OMT/MDs targeting multiple areas of speech pathology intervention within the same study, that is, swallowing, breathing, oral hygiene, and speech production. Majority of studies were rated as low level of evidence. All studies used OMT, with very few using MDs. While the assessment, treatment protocols, and outcome measures were highly variable, all of the studies reported an improvement in the function of the orofacial systems posttreatment. Few studies reported long-term follow-up data. Almost half of the studies recommended the use of OMT/MDs in a multidisciplinary/interdisciplinary team or in conjunction with other therapy.ConclusionsThere has been an increase in literature over the last decade in SLPs' use of OMT; however, there are only a small number of studies to date that explore the use of MDs. There is a growing body of evidence to support the use of OMT and MDs within a multidisciplinary team for people with communication and swallow difficulties. However, development of future research should consider investigating assessment and outcome measures, optimal dosage, and service delivery.
Self-Perceived Handicap Associated With Dysphonia and Health-Related Quality of Life of Asthma and Chronic Obstructive Pulmonary Disease Patients: A Case–Control Study
Authors: Hurtado-Ruzza Rafael , Iglesias Óscar Álvarez-Calderón , Becerro-de-Bengoa-Vallejo Ricardo , Calvo-Lobo César , San-Antolín Marta , Losa-Iglesias Marta Elena , Romero-Morales Carlos , López-López Daniel 
Published: January 2021

PurposeThe association between voice alterations, health-related quality of life (HRQL), and chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), has previously been reported. The aim of this study was to test the hypothesis that HRQL and dysphonia-associated handicap of patients diagnosed with asthma or COPD are worse than healthy controls.MethodA case–control study in which participants were recruited by a consecutive sampling method from a single institution was conducted. Three groups were created: (a) asthma (51 patients), (b) COPD (52 patients), and (c) 50 healthy controls. Self-reported handicap associated with dysphonia was assessed using the 30-item Voice Handicap Index (VHI-30); meanwhile, HRQL was tested via the European Quality of Life (EQ) Questionnaire and the EQ–visual analog scale. Also, aerodynamic assessment applied to phonation was assessed, and maximum phonation time and s/e index were registered.ResultsVHI scores were higher for asthma and COPD (7.19 ± 8.31 and 11.80 ± 15.18, respectively) than in the control group (3.72 ± 6.78). The EQ index was lower in asthma and COPD patients than in controls. The EQ–visual analog scale showed lower scores in asthma and COPD than in the controls.ConclusionsHRQL was worse in COPD patients than in asthma patients. Even though the patient groups showed worse VHI and HRQL scores than the healthy controls, the scores fell within the normal variation range. No significant variations in the maximum phonation time index between groups were noted.
Window‐aware guided image filtering via local entropy
Authors: Liu Chong , Yang Cui , Wang Jun 
Published: January 2021

AbstractGuided image filtering is one of the widely used techniques in computer vision. However, it commonly leads to over‐smoothed edges and a distorted appearance when tackling intricate texture patterns and complex noise. In this paper, a window‐aware image filtering framework based on the bilateral filter guided by the local entropy is presented. The key idea of the authors' proposed approach is to design a novel guidance input and a non‐box filtering window. Specifically, using the Gaussian spatial kernel and the local entropy, a GEF that can maintain image feature details and yield a robust guidance input for BF is constructed. Meanwhile, based on an intensity‐similar strategy, the local non‐box filtering window is designed for the further preservation of edge structures. The authors' approach not only inherits the advantages of bilateral filter i.e. simplicity, parallelisation and easiness of programming, but also is more powerful than bilateral filter and its variants. In addition, the guided entropy filter and the non‐box window can also be transplanted to other local filters and can effectively improve the filtering effects. The qualitative and quantitative experimental results demonstrate that the authors' approach has good performance in image denoising, texture (or background) smoothing, edge extraction and other applications in image processing.
Novel rectangular‐to‐circular waveguide mode converter based on using one‐step double‐cruciform waveguide for millimetre‐wave applications
Authors: Deng Jie , Wu Ke , Li Quxian 
Published: January 2021

AbstractA novel design for a TE10‐mode rectangular waveguide to a TE11‐mode circular waveguide mode converter based on the use of an intermediate one‐step double‐cruciform section is proposed. The converter achieves compactness and broadband by employing the one‐step double‐cruciform transition instead of the conventional multi‐step transitions or smooth transitions. Due to the one‐step structure, the converter achieves an extremely short‐length (around 0.3λ, where λ is the wavelength at the centre frequency), which makes it suitable for highly compact systems. For verification purpose, a back‐to‐back connection rectangular‐to‐circular mode converter was fabricated and measured. The measured results show that the return loss is around 15 dB and the insertion loss is around 0.4 dB in the operating frequency band. Thus, we can infer that the return loss and insertion loss of a single mode converter are around 19 and 0.2 dB, respectively. The experimental results reasonably agree with the simulated results.
Antipsychotische Polypharmazie in der Behandlung von Patientinnen und Patienten mit Schizophrenie am Beispiel von neun psychiatrischen Fachkliniken des Landschaftsverbandes Rheinland
Authors: Schmidt-Kraepelin Christian , Meisenzahl-Lechner Eva , Kujovic Milenko , Cordes Joachim , Engelke Christina , Riesbeck Mathias , Zielasek Jürgen , Engemann Sandra , Vrinssen Jürgen , Lehmann Isabell , Tönnesen-Schlack Anita , Banger Markus , Grümmer Martine , Scherbaum Norbert , Muysers Jutta , Rinckens Stephan , Marggraf Ralph , Gouzoulis-Mayfrank Euphrosyne 
Published: January 2021

ZusammenfassungHintergrund Für die Behandlung von Menschen mit Schizophrenien wird vorrangig antipsychotische Monotherapie empfohlen. Antipsychotische Polypharmazie (APP) wird dennoch oft eingesetzt und dient als Qualitätsindikator.Ziel der Arbeit Das Auftreten von APP an 9 psychiatrischen Kliniken des LVR zu untersuchen und die Nutzbarkeit als Qualitätsindikator zu diskutieren.Material und Methoden Es wurden Behandlungsdaten von stationären und teilstationären Fällen mit der Hauptdiagnose ICD-10 F20.x im Zeitraum 6/2016 bis 6/2017 hinsichtlich der APP-Rate analysiert.Ergebnisse Bei 6788 Behandlungsfällen wurde eine APP-Rate von 55,5 % ermittelt. Männliches Geschlecht, längere Verweildauer, keine Zwangsunterbringung und der Standort der Klinik waren mit APP assoziiert.Diskussion Die APP-Rate ist im Vergleich bisherigen Ergebnissen hoch und weist erhebliche Unterschiede zwischen den Kliniken auf. Die Verwendung des Qualitätsindikators APP wird diskutiert.
Gestational Risk as a Determining Factor for Cesarean Section according to the Robson Classification Groups
Authors: Soares Karina Biaggio , Klein Vanessa Cristina Grolli , Lima José Antônio Reis Ferreira de , Gadenz Lucas , Paulo Larissa Emile , Konopka Cristine Kolling 
Published: January 2021

Abstract
Objective To analyze and compare the frequency of cesarean sections and vaginal deliveries through the Robson Classification in pregnant women attended at a tertiary hospital in two different periods.
Methods Cross-sectional, retrospective study of birth records, comprising 4,010 women, conducted from January 2014 to December 2015 in the only public regional referral hospital for the care of high- risk pregnancies, located in Southern Brazil.
Results The overall cesarean section rate reached 57.5% and the main indication was the existence of a previous uterine cesarean scar. Based on the Robson Classification, groups 5 (26.3%) and 10 (17.4%) were the most frequent ones. In 2015, there was a significant increase in the frequency of groups 1 and 3 (p < 0.001), when compared with the previous year, resulting in an increase in the number of vaginal deliveries (p < 0.0001) and a reduction in cesarean section rates.
Conclusion The Robson Classification proved to be a useful tool to identify the profile of parturients and the groups with the highest risk of cesarean sections in different periods in the same service. Thus, it allows monitoring in a dynamic way the indications and delivery routes and developing actions to reduce cesarean rates according to the characteristics of the pregnant women attended.
Effect of Preoperative Urodynamic Study on Urinary Outcomes after Transobturator Sling
Authors: da Cruz Pedro Rincon Cintra , Dias Filho Aderivaldo Cabral , Furtado Gabriel Nardi , Ferreira Rhaniellen Silva , Resende Ceres Nunes 
Published: January 2021

Abstract
Objective To evaluate whether performing preoperative urodynamic study influences postoperative urinary symptoms of women with stress urinary incontinence that underwent transobturator sling.
Methods Retrospective analysis of patients treated for stress urinary incontinence by transobturator sling from August 2011 to October 2018. Predictor variables included preoperative urodynamic study, age, incontinence severity, body mass index, preoperative storage symptoms and previous anti-urinary incontinence procedure. Outcome variables were postoperative subjective continence status, storage symptoms and complications. Logistic regression after propensity score was employed to compare outcomes between patients who underwent or not pre-operative urodynamic study.
Results The present study included 88 patients with an average follow-up of 269 days. Most patients (n = 52; 59.1%) described storage symptoms other than stress urinary incontinence, and 38 patients (43.2%) underwent preoperative urodynamic studies. Logistic regression after propensity score did not reveal an association between urinary continence outcomes and performance of preoperative urodynamic study (odds ratio 0.57; confidence interval [CI]: 0.11–2.49). Among women that did not undergo urodynamic study, there was a subjective improvement in urinary incontinence in 92% of the cases versus 87% in those that underwent urodynamic study (p = 0.461). Furthermore, postoperative storage symptoms were similar between women who did not undergo urodynamic study and those who underwent urodynamic study, 13.2% versus 18.4%, respectively (p = 0.753).
Conclusion Preoperative urodynamic study had no impact on urinary incontinence cure outcomes as well as on urinary storage symptoms after the transobturator sling in women with stress urinary incontinence.
Pediatric Epilepsy Surgery in Focal and Generalized Epilepsy: Current Trends and Recent Advancements
Authors: Harris William B. , Phillips H. Westley , Fallah Aria , Mathern Gary W. 
Published: January 2021

AbstractFor a subset of children with medically intractable epilepsy, surgery may provide the best chances of seizure freedom. Whereas the indications for epilepsy surgery are commonly thought to be limited to patients with focal epileptogenic foci, modern imaging and surgical interventions frequently permit successful surgical treatment of generalized epilepsy. Resection continues to be the only potentially curative intervention; however, the advent of various neuromodulation interventions provides an effective palliative strategy for generalized or persistent seizures. Although the risks and benefits vary greatly by type and extent of intervention, the seizure outcomes appear to be uniformly favorable. Advances in both resective and nonresective surgical interventions provide promise for improved seizure freedom, function, and quality of life. This review summarizes the current trends and recent advancements in pediatric epilepsy surgery from diagnostic workup and indications through surgical interventions and postoperative outcomes.
Significance and Impact of the Intersphincteric Plane Sepsis in the Management of the Perianal Sepsis: Ultrasound Study
Authors: Youssef Ashraf Talaat 
Published: January 2021

Abstract
Background The intersphincteric plane (ISP) is a potential space between the external and the internal anal sphincters. About 90% of the perianal sepsis is caused by an obstruction of the ducts of anal glands with subsequent secondary bacterial infection. The imaging modalities used to diagnose perianal sepsis are the ultrasound via endoanal and transperineal routes and magnetic resonance imaging.
Objective  The study aimed to identify the various patterns of the ISP sepsis and their incidence among our study group and to clarify the significance of ISP in the pathogenesis of anorectal abscesses and various types of perianal fistula tracts, to optimize the surgical management.
Methods Retrospective descriptive study in which 57 patients with an ISP sepsis were evaluated with full medical history, clinical exam, and ultrasound; the final diagnosis was based on combining the results of ultrasound, digital rectal examination under anesthesia, and the operative results.
Results The current study showed many patterns of the ISP sepsis and estimated the incidence of each pattern among our study group; such patterns could be fistula tracts, sinus tracts, abscesses, intersphincteric abscess with supralevator extension, sinus with abscess formation, fistula with abscess formation, distension of the ISP with free pus, and other complex patterns like horse abscess, abscess with transsphincteric sinus, and ISP fistula/sinus with transsphincteric branches.
Conclusion Understanding the role of the ISP in the pathogenesis of anorectal abscesses and perianal fistula tracts can help in reaching the optimum way of management.