bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture
Authors: Ozan Karakişi Sedat , Hemşinli Doğuş , Tümkaya Levent , Ergene Şaban , Mercantepe Tolga , Yılmaz Adnan 
Published: September 2021

Background: The aim of this study was to examine the effects on the lungs of ischemia/reperfusion injury in a ruptured abdominal aortic aneurysm model in rats and to investigate the potential protective effects of resveratrol.
Methods: Thirty-two male Sprague-Dawley rats were randomly divided into four groups: control, ischemia/reperfusion, sham (ischemia/ reperfusion + solvent/dimethyl sulfoxide), and ischemia/reperfusion + resveratrol. In the groups subjected to ischemia/reperfusion, following 60-min shock to the abdominal aorta, vascular clamps were attached from the levels of the infrarenal and iliac bifurcation. A total of 60-min ischemia was applied, followed by 120-min reperfusion. In the ischemia/ reperfusion + resveratrol group, intraperitoneal 10 mg/kg resveratrol was administered 15 min before ischemia and immediately after reperfusion. Malondialdehyde, glutathione, and catalase levels were analyzed and histopathological examination of the lung tissues was performed.
Results: Malondialdehyde levels increased in the ischemia/reperfusion and ischemia/reperfusion + dimethyl sulfoxide groups, compared to the control group, while catalase levels decreased, and no significant difference was observed in the glutathione levels. Malondialdehyde levels decreased with the administration of resveratrol, while glutathione levels increased, and catalase levels remained unchanged. The increased inflammation in interstitial spaces, thickening in the alveolar septal walls, increased numbers of cleaved caspase-3 apoptotic pneumocytes, and increased histopathological lung damage scores observed in the ischemia/reperfusion and ischemia/reperfusion + dimethyl sulfoxide groups improved with the application of resveratrol.
Conclusion: These findings suggest that resveratrol may exhibit a protective effect in preventing acute lung injury developing due to ischemia/reperfusion in ruptured abdominal aortic aneurysm surgery by reducing oxidative damage.
Isolation and Antibacterial Properties of Phenyl Acrylic Acid Derivatives from Balanophora elongata Blume
Authors: Arbain Dayar , Bakhtiar Amri , Syafni Nova , - Nofrizal , Faroliu Goldha , Putra Nanda 
Published: September 2021

Balanophora elongata (Balanophoraceae) is a tropical parasitic flowering plant 9 cm in height. Four known phenyl acrylic acid derivatives, methyl caffeate (1), caffeic acid (2), 1,6-di-O-caffeoyl-β-D-glucopyranose (3), and coniferin (4), were isolated from this plant. Structural elucidation of the isolated compounds was determined by IR, LC-ESI-MS, 1D and 2D NMR. Extracts and isolated compounds were tested toward some standard human pathogenic bacteria using the agar disk diffusion method. Their inhibition zones were compared to that of chloramphenicol as positive control. Compound 1 showed inhibition toward Streptococcus mutans, while compound 3 and 4 inhibited Staphylococcus aureus.
TECTONIC AND EROSION FEATURES, AND THEIR INFLUENCE ON ZONAL DISTRIBUTION OF THE UPPER TRIASSIC AND THE LOWER CRETACEOUS SEDIMENTS IN THE EUPHRATES GRABEN AREA, SYRIA
Authors: Yousef I. , Morozov V. P. , El Kadi Mohammad , Alaa Abdullah 
Published: September 2021

We have investigated the tectonic and erosion features of the Upper Triassic (Mulussa F Formation) and Lower Cretaceous (Rutbah Formation) sediments in the Euphrates graben area and analysed their influence on changes in the thickness and zonal distribution patterns of these sediments. In this study, the geological modeling software of Petrel Schlumberger is used to model the regional geological structure and stratigraphy from the available geological and geophysical data.The Upper Triassic and Lower Cretaceous sediments (in total, almost 800 m thick) are the major hydrocarbon reservoirs in the Euphrates graben, which contain approximately 80 to 90 % of the total hydrocarbon reserve in this area. These sedimentary zones experienced variable changes in thickness and zonal distribution due to erosion processes caused by the two major regional unconformities, the Base Upper Cretaceous (BKU) and Base Lower Cretaceous (BKL) unconformities. The maximum thickness of the Upper Triassic sediments amounts to 480 m in the central parts of the Euphrates graben and along the NW-SE trend, i.e. in the dip direction of the Upper Triassic Mulussa F Formation. Towards the NE flank of the graben near the Khleissia uplift and the SW flank near to the Rutbah uplift, the thickness of the Upper Triassic sediments is gradually decreased due to their partial or total erosion caused by the BKL unconformity, and also due to a less space for sediment accumulation near the uplifts. The thickness of the Lower Cretaceous sediments increases in the northern, NW and NE flanks of the graben. Their maximum thickness is about 320 m. The BKL unconformity is the major cause of erosion of the Lower Cretaceous sediments along the southern, SE and SW flanks of the graben. In the Jora and Palmyra areas towards the NW flank of the Euphrates graben, the Upper Triassic and Lower Cretaceous sediments show no changes in thickness. In these areas, there was more space for sediment accumulation, and the sediments were less influenced by the BKL and BKU unconformities and thus less eroded.
LITHOLOGICAL AND FACIAL FEATURES, COMPOSITION, AND SEDIMENTATION CONDITIONS OF TERRIGENOUS-CARBONATE ROCKS OF THE MOTY GROUP (SHAMAN CLIFF, IRKUTSK REGION)
Authors: Motova Z. L. , Plyusnin A. V. , Nikulin E. V. 
Published: September 2021

We have studied terrigenous-carbonate rocks in the area near the Sayan mountains in the Irkutsk Region (Russia), specifically at the Shaman Cliff, being the stratotype area of rocks that belong to the Moty group. The cliff’s lower part is composed of sandstones, which fragments gradually decrease in size upward the cross-section. The middle and upper parts are composed of sandy dolomites and dolomites, respectively. In terms of material characteristics, the terrigenous rocks correspond to arkoses. According to the genetic typification, the arkoses are composed of destructed primary igneous rocks. The terrigenous-carbonate rocks contain a carbonate component that gradually increases in the upper part of the cross-section. In the Shaman Cliff cross-section, we distinguish 32 lithological units and eight lithologicalgenetic types of deposits. Paleogeodynamic conditions are reconstructed for the formation of the sedimentation basin. Our study of the Shaman formation reveals specific features of the lithological facies, which suggest that these rocks accumulated in a coastal environment affected by tides. In the study area, clastic materials were mainly removed from an orogen that formed due to the Vendian accretion-collision events in the southern folded frame of the Siberian platform. Dolomites composing the upper part of the cliff are attributed to the Irkutsk formation of the Moty group. Their lithological features give evidence of shallow-marine conditions of their formation, without any supply of clastic material, which contributed to mass dispersal of the Cambrian biota described in [Marusin et al., 2021]. It is our first initiative to draw a boundary between the Shaman and Irkutsk formations of the Moty Group along the base of the carbonate eluvial breccia unit that marks the stratigraphic break. In the cross-section, this boundary represents the border between the Upper Vendian and Lower Cambrian.Our conclusions are generally consistent with the ideas of most researchers about the Late Vendian evolution of the southern margin of the Siberian platform. The results of our study can be used in further investigation of this area and provide a basis for correlating the studied strata with the same-age reference cross-sections of other regions in Siberia.
Internacionalização do ensino superior e a mobilidade acadêmica
Authors: Pessoni Rosemeire Bom , Pessoni Arquimedes 
Published: September 2021

Este estudo retrata e discute a globalização e a internacionalização do ensino superior com ênfase em um dos principais aspectos da internacionalização da educação - a mobilidade acadêmica. Pesquisas nessa área têm crescido substancialmente nos últimos anos e alguns autores têm se destacado no cenário internacional como Altbach e Knight (2007); Gacel-Ávila (2005); Knight (2003, 2005, 2012) e Wilkins e Hubman (2012). No Brasil diversos autores também têm se dedicado à essa temática, a exemplo de Carvalho e Maia (2014); Dias Sobrinho (2010); Lima e Contel (2011); Lima e Maranhão (2009, 2011); Miura (2006); Morosini (2006, 2014); Silva (2018); Stallivieri (2009, 2017) entre outros, e os dados dos relatórios da OCDE e da UNESCO fundamentam esse estudo. Assim, partir da visão de diferentes autores, esse trabalho visa contribuir para a discussão dos aspectos positivos e negativos da internacionalização, as contradições que esse tema suscita e as suas implicações para as universidades.
Numerical Study on Multiple-Blade-Rate Unsteady Propeller Forces for Underwater Vehicles
Authors: Takahashi Kenshiro , Arai Jun , Mori Takayuki 
Published: September 2021

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The unsteady propeller forces of an underwater vehicle were numerically simulated using computational fluid dynamics to investigate the effects of the axial location of the stern planes. A benchmark study was undertaken using a three-bladed propeller; experimental results of the nominal inflow wake profile were analyzed and the unsteady propeller forces were measured. The numerical method was applied to predict the unsteady propeller forces in the SUBOFF model’s wake by varying the axial locations of the stern planes. Several remarks were made on the primary harmonics of the hull’s wakes and blade-rate propeller forces.

Introduction
The hydroacoustic noise, which matches multiples of the number of propeller blades and its rotational speed, known as “blade-rate (BR) noise,” has been increasingly used to manage hydroacoustics for naval vessels. BR noise can be caused by alternating blade loads owing to fluctuations in the angle of attack of the blades because marine propellers are operated in the nonuniform wake of ships’ hulls. The unsteady blade load produces unsteady propeller forces that are transmitted via the propeller shaft and bearing, thus producing undesirable vibration and noise. Although the resultant BR noise is a common issue for marine vessels, in particular, submarines and other underwater vehicles deployed for undersea defense systems and oceanographic survey systems require strict specifications for the acoustic signature. Therefore, the unsteady propeller forces must be improved for reduced detectability, because the vehicles should be able to operate without being discovered while sonar detection technology continues to improve.
Navigating the amino acid sequence space between functional proteins using a deep learning framework
Authors: Bitard-Feildel Tristan 
Published: September 2021

MotivationShedding light on the relationships between protein sequences and functions is a challenging task with many implications in protein evolution, diseases understanding, and protein design. The protein sequence space mapping to specific functions is however hard to comprehend due to its complexity. Generative models help to decipher complex systems thanks to their abilities to learn and recreate data specificity. Applied to proteins, they can capture the sequence patterns associated with functions and point out important relationships between sequence positions. By learning these dependencies between sequences and functions, they can ultimately be used to generate new sequences and navigate through uncharted area of molecular evolution.ResultsThis study presents an Adversarial Auto-Encoder (AAE) approached, an unsupervised generative model, to generate new protein sequences. AAEs are tested on three protein families known for their multiple functions the sulfatase, the HUP and the TPP families. Clustering results on the encoded sequences from the latent space computed by AAEs display high level of homogeneity regarding the protein sequence functions. The study also reports and analyzes for the first time two sampling strategies based on latent space interpolation and latent space arithmetic to generate intermediate protein sequences sharing sequential properties of original sequences linked to known functional properties issued from different families and functions. Generated sequences by interpolation between latent space data points demonstrate the ability of the AAE to generalize and produce meaningful biological sequences from an evolutionary uncharted area of the biological sequence space. Finally, 3D structure models computed by comparative modelling using generated sequences and templates of different sub-families point out to the ability of the latent space arithmetic to successfully transfer protein sequence properties linked to function between different sub-families. All in all this study confirms the ability of deep learning frameworks to model biological complexity and bring new tools to explore amino acid sequence and functional spaces.
Assessment of Aleutian mink disease virus (AMDV) prevalence in feral American mink in Iceland. Case study of a pending epizootiological concern in Europe
Authors: Panicz Remigiusz , Eljasik Piotr , Skorupski Jakub , Śmietana Przemysław , Stefánsson Róbert A. , von Schmalensee Menja , Szenejko Magdalena 
Published: September 2021

Background
Recurring escapes or deliberate releases and subsequent infiltration or establishment of feral populations by individuals from fur farms have been commonly noted since the beginning of fur industry expansion. Once animals have invaded ecosystems adjacent to source farms escapees can change the demography of the feral populations through hybridization, outbreeding depression, competition and spreading of various pathogens which can decimate wild populations. In our study, we aimed to assess spread of Aleutian mink disease virus (AMDV) in the feral population of American mink (Neovison vison) in Iceland. The additional objective was to elucidate whether basic morpho-anatomical parameters (i.e., Fulton’s condition factor or spleen to body weight ratio) might be used as a preliminary indicator of AMDV infection.

Methods
American mink (n = 164) were captured by professional hunters in 8 regions of Iceland. The detection of AMDV in the spleen of male and female individuals was based on PCR amplification of an NS1 gene fragment.

Results
We confirmed AMDV presence in 23.8% (n = 39) of collected samples with no significant difference in infection rate between males and females. Additionally, we revealed that the prevalence of virus in the feral population was higher closer to fur farms. However, the countrywide prevalence and direction of AMDV distribution needs to be further investigated. Comparison of condition indices in non-infected and infected animals showed significant deterioration of body and spleen parameters in the latter group. Therefore, the application of basic measurements of the American mink may be used to evaluate the health status of individuals in terms of pathogen infection.

Conclusions
The study shed a new light on prevalence and distribution of AMDV in the feral population of American mink in Iceland and the results might be successfully applied to develop models to infer dynamics of various pathogens, even those latently transmitted by disease-free animals.
Exosomal hsa-miR-21-5p is a biomarker for breast cancer diagnosis
Authors: Liu Min , Mo Fei , Song Xiaohan , He Yun , Yuan Yan , Yan Jiaoyan , Yang Ye , Huang Jian , Zhang Shu 
Published: September 2021

Purpose
Breast cancer (BC) is characterized by concealed onset, delayed diagnosis, and high fatality rates making it particularly dangerous to patients’ health. The purpose of this study was to use comprehensive bioinformatics analysis and experimental verification to find a new biomarker for BC diagnosis.

Methods
We comprehensively analyzed microRNA (miRNA) and mRNA expression profiles from the Gene Expression Omnibus (GEO) and screened out differentially-expressed (DE) miRNAs and mRNAs. We used the miRNet website to predict potential DE-miRNA target genes. Using the Database for Annotation, Visualization and Integrated Discovery (DAVID), we performed Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses on overlapping potential target genes and DE-mRNAs. The protein-protein interaction (PPI) network was then established. The miRNA-mRNA regulatory network was constructed using Cytoscape and the analysis results were visualized. We verified the expression of the most up-regulated DE-miRNA using reverse transcription and a quantitative polymerase chain reaction in BC tissue. The diagnostic value of the most up-regulated DE-miRNA was further explored across three levels: plasma-derived exosomes, cells, and cell exosomes.

Results
Our comprehensive bioinformatics analysis and experimental results showed that hsa-miR-21-5p was significantly up-regulated in BC tissue, cells, and exosomes. Our results also revealed that tumor-derived hsa-miR-21-5p could be packaged in exosomes and released into peripheral blood. Additionally, when evaluating the diagnostic value of plasma exosomal hsa-miR-21-5p, we found that it was significantly up-regulated in BC patients. Receiver operating characteristic (ROC) analysis also confirmed that hsa-miR-21-5p could effectively distinguish healthy people from BC patients. The sensitivity and specificity were 86.7% and 93.3%, respectively.

Conclusion
This study’s results showed that plasma exosomal hsa-miR-21-5p could be used as a biomarker for BC diagnosis.
The Impact of Conservation Agriculture Practice and Socio-Economic Factors on Yam Production (Dioscorea alata and Dioscorea rotundata) in Kalagoé (Lobaye, Central African Republic)
Authors: Touckia G. I. , Aba-Toumnou L. , Yongo O. D. , Yara M. Ganima , Kokou K. 
Published: September 2021

Few studies have been carried out on Yam (Dioscorea alata and Dioscorea rotundata) in relation with the conservation agriculture in CAR. Yam is cultivated in limited quantities despite its role in improving food security. In order to increase Yam production in the smallholder farms in CAR, the potential effect of crop management practices like nutrient application, mulching and minimum tillage on Yam crop yield and household financial returns, needs to be understood. A questionnaire was prepared and used as a tool for the collection of information from 100 producers of Yam without distinction of ages and sexes. In order to determinate the agronomical performance of Yam, two plots were explored. The first plot with 625m² (12.5m ×50m), known as the improved plot, is a plot on which all conservation agriculture practices were applied. The second plot, known as the traditional plot, is one on which traditional farming techniques were applied. The results of the survey show that 32% of the farmers are in favor for CA practice nevertheless 68% are not favor, which shows that a large proportion of farmers in Kalangoé are not aware of the benefits of this technique. The most widely cultivated variety is D. rotundata, because of its taste qualities. Some producers also grow both varieties at the same time. Some producers (28%) clear their plots by cutting down all the trees to leave the field bare, while a large number (72%) practice partial cutting by removing the shrubs to keep the large trees in order to protect the forest. A large number of producers (62%) also burn their plots for various reasons, including freeing up space and making it easier to move around the field because the plant debris from clearing prevents them from working properly. A small proportion of producers (26%) practice ploughing against 74% who do not practice this technique. The conservation agriculture practice applied to Yam gave interesting agronomic performances (growth and production parameters) than the farmers practices.
Prevalence of Intestinal Parasitic Infection in Relation to Age in the Urban Population from Chandigarh, India
Authors: Mehta Manjula , Bhardwaj Sonia Bhonchal , Sharma Jyoti 
Published: September 2021

Background: Intestinal parasitic infection is a global health problem particularly in the developing countries with different prevalence rates in different regions. The aim of this study was to evaluate the prevalence of intestinal parasitic infection in different age groups in the urban population of Chandigarh, India.
Materials and Methods: The retrospective study included stool samples 504 in number from human subjects from Chandigarh. Unstained wet saline mount preparations of stool sample were done to detect eggs or larvae and iodine wet mount to detect ova/ cysts of tapeworm, Enterobius, Ascaris, Giardia, Trichuris and Hookworm.
Results: A high prevalence rate of intestinal parasitosis (73%) was seen. The age group distribution shows a higher prevalence of intestinal parasitic infection in the young population (age group 21-30 years and 31-40 years). Ascariasis was the most common parasitic infection observed.
Conclusion: The present study reveals a high prevalence of intestinal parasitic infection in the study population and calls for long term control measures to improve their sanitary and living conditions.
HERD BEHAVIOR IN USING MOBILE PAYMENT WITH UNIFIED THEORY OF ACCEPTANCE AND USE OF TECHNOLOGY (UTAUT2)
Authors: Armansyah Rohmad Fuad 
Published: September 2021

The development of information technology, followed by higher bank competition, has encouraged innovation in providing various alternatives for non-cash payments. Mobile payment services are increasingly popular with the increasing use of smartphones in the last five years in Indonesia, so that financial behavior has shifted its function towards digitalization. This study aims to discuss the financial herding behavior of using mobile payments using the Unified Theory of Acceptance and Use of Technology (UTAUT2) approach. The data used is respondent data as many as 355 Indonesian students who use the mobile payment application on a mobile device. The results obtained by the variable performance expectance and price value have a significant effect on the behavioral intention of users of mobile payment applications in Indonesia. Then behavioral intention was proven to significantly influence usage behavior and herd behavior as a form of financial behavior deviation which was proven to affect performance expectations.
Race and the politics of exclusion: The socio‐historical contexts of Black brutality and the emergence of the Black Lives Matter movement
Authors: Alfred Mary V. 
Published: September 2021

AbstractThe fight for racial justice has been an ongoing battle for African Americans for centuries, a battle that is currently championed by the Black Lives Matter (BLM) movement, the latest civil rights movement in a long fight for Black equality and social justice. To understand the historical contexts and backdrop for the fight for Black lives, this article begins with a historical timeline depicting important events in the fight for racial justice, followed by a discussion of the BLM movement and the role racial capitalism plays in the subjugation of Black Americans. Intersectionality is presented as a guiding framework for illuminating the complexities of Black lives within a capitalist system.