bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatigue and cognitive impairment in post-COVID syndrome: possible treatment approaches
Authors: Bogolepova A. N. , Osinovskaya N. A. , Kovalenko E. A. , Makhnovich E. V. 
Published: August 2021

Post-COVID syndrome can develop in all patients who have had COVID-19, regardless of the disease severity. Clinical manifestations postCOVID syndrome vary greatly, but the most common symptoms include fatigue, anxiety and depression disorders (ADDs), and cognitive impairment (CI).Objective: to evaluate the efficacy and safety of Cholytilin (choline alfoscerate) and the combined drug MexiB 6 in patients with post-COVID syndrome and fatigue, ADDs, and CI.Patients and methods. The study included 100 patients aged 22 to 71 years who have had COVID-19 5.4 months ago. Inclusion criterion: cognitive complaints, fatigue, and emotional disturbances. The evaluation included neurological exam, Montreal Cognitive Assessment Scale (MoCA), Frontal Assessment Battery (FAB), 10-words list task, Multidimensional Fatigue Inventory (MFI-20), Hospital Anxiety and Depression Scale (HADS). Study participants were divided into two groups. Patients who had ADDs (anxiety/depression level according to HADS ≥8 points; n=50) were prescribed with MexiB 6 (1 tablet three times per day). Patients with CI (mean MoCA score ≤25 points; n=50) were prescribed with Cholytilin (2 capsules (800 mg) in the morning and 1 capsule (400 mg) at lunchtime). The follow-up period was 60 days.Results and discussion. According to MoCA scores, a decrease in cognition was observed in 58% of participants, while 28% did not notice CI earlier. ADD fere present in 51%, and fatigue — in 100% of patients. We observed a significant reduction in fatigue severity (from 62.42±7.18 to 52.32±16.36 points; p<0.05) in patients prescribed with MexiB 6. The majority of patients noted a significant increase in physical activity, decreased fatigue, improvement of attention and physical well-being, and increased workplace efficiency. We also found a significant decrease in ADDs severity: ADDs either regressed completely (in 42% of participants) or became subclinical (in 48%; р<0.001). CI severity also reduced according to mean МоСА (from 26.60±1.31 to 27.28±1.39 points; p<0.05) and FAB (from 16.98±1.06 to 17.20±0.90 points; p<0.05) scores. In a subgroup of patients with mild CI treated with Cholytilin mean МоСА (from 23.50±0.99 to 26.36±1.34; р<0.001) and FAB (from 16.02±0.91 to 16.96±0.99; р<0.001) scores significantly increased. Complete regression of CI was observed in 74% of participants (р<0.001). We also found a decrease in ADDs (р<0.001) and fatigue (mean MFI-20 scores decreased from 42.28±10.73 to 35.60±8.10; р<0.001) severity in all study participants.Conclusion. Patients who have had COVID-19, regardless of the disease severity, have a high prevalence of fatigue, ADDs and CI, and MexiB 6 and Cholytilin have a potential in their treatment.
IncobotulinumtoxinA in the treatment of sialorrhea in patients with infantile cerebral palsy
Authors: Kurenkov A. L. , Kuzenkova L. M. , Chernikov V. V. , Bursagova B. I. , Nezhelskaya A. A. , Artemenko A. R. 
Published: August 2021

Sialorrhea is a severe medical problem that is difficult to treat, which can lead to serious complications. In almost all cases, chronic sialorrhea is accompanied by a restriction of the child's contacts with peers, socialization difficulties, and a significant decrease in the quality of life. Nowadays, botulinum therapy can be an effective tool that significantly reduces sialorrhea manifestation.Oblective: to evaluate the effectiveness of Xeomin (incobotulinumtoxinA) in the treatment of sialorrhea in patients with spastic infantile cerebral palsy (ICP).Patients and methods. We enrolled 24 children with ICP (14 (58.3%) females, and 10 (41.7%) males) with various disease forms: 4 (16.6%) — with spastic hemiparesis, 6 (25.0%) — with spastic diplegia, and 14 (58.3%) — with spastic quadriparesis. IncobotulinumtoxinA injections were performed bilaterally in the parotid and submandibular salivary glands under ultrasound control at a total dose of 40-100 U (min 1.3, max 4.5 U/kg of body weight). IncobotulinumtoxinA. The Drooling Impact (DIS) and the Global Impression of Change Scale (GICS) were used 1, 3 and 6 months after IncobotulinumtoxinA injections to assess treatment effectiveness.Results and discussion. Botulinum toxin therapy resulted in a significant decrease in saliva discharge from the oral cavity 1 and 3 months after IncobotulinumtoxinA injections, which was demonstrated by a reduction in mean DIS score from 78.6±9.6 (min 62, max 95 points; 95% CI 74.6—82.7) to 48.7±6.7(min 25, max 61 points; 95% CI45.8—51.6) and 52.7±8.5points (min 22, max 65; 95% CI49.1—56.3), respectively, as well as an increase in delta GICSscore up to +1.3+0.8(min 0, max 3points; 95% CI 1.0—1.6) and +1.0+0.7points (min 0, max 3points; 95% CI 0.8—1.3), respectively. Adverse events were observed in 4patients (16.6%), which were classified as mild in 3 patients (did not require special treatment and completely stopped within six days) and moderate in 1 patient (also did not require special treatment and completely stopped within three weeks).Conclusion. In the majority (79.1%) of patients with ICP, it is possible to achieve high efficiency in reducing sialorrhea and this effect persists for at least 3 months.
The Effect of Seven Etching Solutions used for the Differentiated Visualization of Complex Microstructures in Low-Alloyed Cast Iron
Authors: Duwe S. , Tonn B. 
Published: August 2021

Abstract
For numerous steel grades, detailed descriptions of different etching techniques and etching times for microstructural analysis are available. However, there are only few reference works for low-alloyed cast iron. Particularly for complex microstructures with combined fractions of bainite, ferrite, pearlite, retained austenite, carbides and martensite, there are only few detailed collections. In addition, the effects of the etchants are rarely investigated for the same image section. Therefore, this study will exclusively compare identical microstructural regions and the effect of different etchants on them.
Two specific sample areas were selected in a low-alloyed cast iron and the effect of both surface removal etching and tint etching reagents on them was examined under a reflected light optical microscope and a scanning electron microscope.
The results of the study have shown that some etchants for complex microstructures are only suitable in case potentially present phases are already known. However, the combined use of two etching solutions in particular, led to a very detailed and highcontrast image, capable of revealing and resolving microstructures with a variety of phases.
The functions of the verb ‘to say’ in the Jordanian Arabic dialect of Irbid
Authors: Al-Shawashreh Ekab , Jarrah Marwan , Zuraikat Malek J. 
Published: August 2021

AbstractThis research investigates the functions of the verb ‘to say’ in the Jordanian Arabic dialect of Irbid (JADI). Relying on a 250,000-word corpus, we propose that the speech verb ‘to say’ in JADI has one main lexical function (i.e. introducing direct or indirect speech) in addition to three functions which the verb develops, i.e. expressing the speaker’s mental state, signalling indirect evidentiality, and revealing the speaker’s incredulity towards the accompanying utterance. We show that in these three developed functions, the verb lost one or more of its lexical properties, because of an (initial or advanced) grammaticalization process whose effects are clearly manifested by the function of the verb as an incredulity marker, in which case the verb is semantically bleached, phonologically reduced, and de-categorized. Following Traugott (1989), Wang et al. (2003) and Hsieh (2012), among others, we propose that the grammaticalization path of the speech verb in JADI into these three functions are motivated by pragmatic inference and (inter)subjectification. The directionality of the grammaticalization process is also shown to be implemented from propositional (through textual) to expressive functions.
Unrundwalzen – Walzen unrunder Querschnitte
Authors: Peter Roe Christopher , Kriwall Mareile , Stonis Malte , Behrens Bernd-Arno 
Published: August 2021

Abstract
Das Flachbackenwalzen ist der Massivumformung zuzuordnen, in welchem zwei mit Gravuren versehene Werkzeugplatten aneinander vorbeilaufen und dabei ein zylindrisches Halbzeug umformen. Mithilfe des Unrundwalzens als Vorformverfahren soll es ermöglicht werden, lokal unrunde Abschnitte, beispielsweise Ellipsen oder Exzenter in ein Halbzeug zu formen. Der Stofffluss soll ausschließlich in radialer Richtung vorliegen. Erste Simulationen zeigen, dass die genannten Anforderungen erfüllt werden können.
Oberflächenmorphologie gefräster Aluminiumwerkstücke
Authors: Weber Daniel , Kirsch Benjamin , Gutzeit Kevin , Linke Barbara S. , Hill Michael R. , Aurich Jan C. 
Published: August 2021

Abstract
Das Einsatzverhalten dünnwandiger, monolithischer Aluminiumlegierungen, welche in der Luft- und Raumfahrtindustrie eingesetzt werden, wird maßgeblich durch deren Oberflächenmorphologie beeinflusst. Diese setzt sich aus den mechanischen und metallurgischen Randschichteigenschaften sowie der Oberflächentopografie zusammen. In diesem Beitrag wird der Einfluss der Schnittparameter auf die Rauheit, die Mikrostruktur, die Mikrohärte sowie auf prozessinduzierte Eigenspannungen von gefrästem Al 7050 untersucht.
Energieeffizientes Recycling von Titanspänen
Authors: Denkena Berend , Dittrich Marc-André , Kettelmann Simon 
Published: August 2021

Abstract
Eine neue Prozesskette ermöglicht das direkte Recycling von Titanspänen für die additive Fertigung. Die Prozesskette bietet Potenzial zur Verbesserung der ökologischen Nachhaltigkeit in der additiven Herstellung von Titanbauteilen. Im Vergleich zur Verwendung von Primärtitanpulver sind erhebliche Ressourceneinsparungen möglich. Zusätzlich kann das Recycling von Spänen zu Pulver für die additive Fertigung eine ressourcensparende Alternative zum Recycling zu Vollmaterial sein.
Fuzzy-gestützte Messdatenauswertung zur Prozessoptimierung an Werkzeugmaschinen
Authors: Blum Andreas , Diban Raphael al , Rudolph Mathias , Weickhardt Christian 
Published: August 2021

Abstract
Durch die Möglichkeit, Wartungsintervalle dynamisch und zustandsabhängig planen zu können, gewinnen messdatengetriebene Instandhaltungskonzepte in modernen Fertigungslinien zunehmend an Bedeutung. Diese erlauben neben der Gewährleistung einer gleichbleibenden Prozessqualität die Schonung von Ressourcen. Bestehende Zustandsüberwachungen nutzen eine auf Kenn- und Grenzwerten basierende Messdatenauswertung. Alternativ dazu wird hier ein Verfahren der unscharfen Auswertung zur Prozessoptimierung an Werkzeugmaschinen vorgestellt, das keine Definition einzelner Grenzwerte erfordert, sondern basierend auf Methoden des maschinellen Lernens einen robusten Algorithmus zur Verfügung stellt, mit dem sich der Prozesszustand vorgegebenen Klassen zuordnen lässt. So lassen sich Unregelmäßigkeiten im Prozess anhand der Klassenzugehörigkeitswerte identifizieren und Diagnosefehler vermeiden.
Prevalence of Normal Weight Obesity and Health Risk Factors for the Female Collegiate Dancer
Authors: Brown Ann F. , Alfiero Christopher J. , Brooks Samantha J. , Kviatkovsky Shiloah A. , Smith-Ryan Abbie E. , Ormsbee Michael J. 
Published: August 2021

Abstract
Brown, AF, Alfiero, CJ, Brooks, SJ, Kviatkovsky, SA, Smith-Ryan, AE, and Ormsbee, MJ. Prevalence of normal weight obesity and health risk factors for the female collegiate dancer. J Strength Cond Res 35(8): 2321–2326, 2021—The purpose of this study was to investigate the prevalence of normal weight obesity (NWO) and evaluate the relationship between NWO and health risk factors in a collegiate dancer population. Reanalysis of data of female dancers (N = 42) from 2 larger studies was used to assess prevalence and health risk factors of NWO. Dancers completed a dual-energy x-ray absorptiometry scan to assess fat mass (FM), lean mass (LM), and visceral adipose tissue (VAT) and a 3-day food record. Normal weight obesity was defined as a body mass index (BMI) of 18.5–24.9 kg·m−2 and body fat (BF) ≥30%. Twenty-five (60%) dancers were classified as normal weight lean (NWL), and 17 dancers (40%) were classified as NWO. Significant differences were observed for BMI (NWL: 21.1 ± 1.7, NWO: 23.1 ± 1.6, p < 0.001), LM (NWL: 71.0 ± 2.9%, NWO: 62.5 ± 2.7%, p < 0.001), %BF (NWL: 24.8 ± 3.1%, NWO: 33.9 ± 2.6%, p < 0.001), and VAT (NWL: 130.6 ± 43.0 g, NWO: 232.3 ± 70.8 g, p < 0.001) between NWL and NWO. A significant difference was observed for carbohydrate intake (NWL: 4.7 ± 1.8 g·kg−1, NWO: 3.7 ± 1.0 g·kg−1, p = 0.020) between groups. Significant positive correlations with FM were observed between carbohydrate (kcal, p = 0.048), fat (kcal, p = 0.018; g·kg−1, p = 0.040), and total calories (p = 0.019) in NWO. Normal weight obesity in collegiate dancers may be more prevalent than previously perceived and may be significantly related to important health risk factors. The current study demonstrates the need for body composition assessments and emphasizing on promoting overall health in collegiate dancers.
Laser Capture Microdissection of Single Neurons with Morphological Visualization Using Fluorescent Proteins Fused to Transmembrane Proteins
Authors: Chang Ching Ching , Chong Hai Tarng , Tashiro (田代 歩) Ayumu 
Published: August 2021

AbstractGene expression analysis in individual neuronal types helps in understanding brain function. Genetic methods expressing fluorescent proteins are widely used to label specific neuronal populations. However, because cell type specificity of genetic labeling is often limited, it is advantageous to combine genetic labeling with additional methods to select specific cell/neuronal types. Laser capture microdissection is one of such techniques with which one can select a specific cell/neuronal population based on morphological observation. However, a major issue is the disappearance of fluorescence signals during the tissue processing that is required for high-quality sample preparation. Here, we developed a simple, novel method in which fluorescence signals are preserved. We use genetic labeling with fluorescence proteins fused to transmembrane proteins, which shows highly stable fluorescence retention and allows for the selection of fluorescent neurons/cells based on morphology. Using this method in mice, we laser-captured neuronal somata and successfully isolated RNA. We determined that ∼100 cells are sufficient to obtain a sample required for downstream applications such as quantitative PCR. Capability to specifically microdissect targeted neurons was demonstrated by an ∼10-fold increase in mRNA for fluorescent proteins in visually identified neurons expressing the fluorescent proteins compared with neighboring cells not expressing it. We applied this method to validate virus-mediated single-cell knockout, which showed up to 92% reduction in knocked-out gene RNA compared with wild-type neurons. This method using fluorescent proteins fused to transmembrane proteins provides a new, simple solution to perform gene expression analysis in sparsely labeled neuronal/cellular populations, which is especially advantageous when genetic labeling has limited specificity.
Розвиток гнучкості хребта у спортсменів, які займаються пауерліфтингом
Authors: Толубенко Єлизавета 
Published: August 2021

Мета дослідження – визначити вплив амплітуди руху на результати жиму лежачи у спортсменів, які займаються пауерліфтингом. Матеріали і методи. У дослідженні брали участь дві групи по 10 спортсменів, які займаються пауерліфтингом – юнаки віком 19-20 років. У роботі використано такі методи: спостереження, методи теоретичного аналізу та узагальнення, педагогічний експеримент, педагогічне тестування, методи математичної статистики. Дослідження тривали упродовж п’яти місяців (з 02.11.2019 по 28.03.2020) у ДЮСШ ХТЗ. Комплекси вправ були впровадженні в тренувальний процес спортсменів експериментальної групи. Результати. Результати свідчать про статистично достовірні зміни тренувальних ефектів комплексів вправ на гнучкість хребта у спортсменів експериментальної групи (р < 0,001). Спортсмени даної групи в середньому зменшили амплітуду руху штанги на 4,1 см, що дало їм змогу збільшити силові показники жиму лежачи. Висновки. Після виконання комплексів вправ на гнучкість амплітуда руху штанги у спортсменів експериментальної групи статистично достовірно зменшилася, що позитивно вплинуло на показники жиму лежачи.
Prognostic Value of Residual Coronary Artery Lesions on the SYNTAX Scale in Patients with Acute Myocardial Infarction without SТ Segment Elevation in the Mid-Term Period
Authors: Rafaeli I. R. , Kireeva A. Yu. , Rogatova A. N. , Azarov Al. V. , Semitko S. P. 
Published: August 2021

Aim To study the effect of residual coronary injury after a percutaneous coronary intervention (PCI), as evaluated with the SYNTAX scale (residual SYNTAX score, RSS), on the mid-term prognosis for patients with non-ST elevation acute myocardial infarction (NSTEMI) and also to determine threshold RSS values for patients at high and low risk of adverse cardiac events.Material and methods A single-center, retrospective study was performed. From 421 patients with NSTEMI after PCI with stenting, 169 patients were selected who originally had multivessel coronary disease and who had undergone a repeated inpatient examination, including mid-term (11.7±3.0 mos.) coronary angiography. The endpoints were recurrent clinical manifestations of angina, repeat revascularization (RR), unstable angina (UA), recurrent acute myocardial infarction (AMI), cardiac death, and also a composite endpoint (major adverse cardiac events, MACE) that included UA, recurrent AMI, and cardiac death. After revealing a significant direct correlation between RSS and the probability of recurrent AMI, UA, MACE, or RR (p <0.05) using the ROC analysis, we have established threshold RSS values that divided patients into groups with high and low risk of the cardiac events listed above.Results For a significantly high risk of recurrent AMI (area under the curve, AUC 0.79±0.05; 95 % confidence interval, CI 0.68–0.89; р=0.048), the threshold RSS score was 8 (sensitivity 100 %, specificity 70.9 %). For UA and MACE, the RSS scores were both 3 (AUC 0.68±0.5; 95 % CI 0.58–0.79; p=0.005 and AUC 0.71±0.05; 95 % CI 0.61–0.8; p=0.001, respectively). The probability of UA during the observation period with RSS >3 was 4.07 times higher and that of MACE was 5.23 times higher than with RSS<3 (95 % CI 1.44–11.49; р=0.01 and 95 % CI 1.88–14.53; р=0.001, respectively).Conclusion The study demonstrated a significant, direct correlation between the RSS and the risk of adverse cardiac events in patients with NSTEMI during one year of observation. Specific threshold values were obtained, which may help in choosing both the extent of revascularization and the tactics for postoperative management of patients.
Interim Results of the BYHEART Observational Study: Exogenous Phosphocreatine Effect on the Quality of life of Patients with Chronic Heart Failure
Authors: Tereschenko S. N. , Perepech N. B. , Cheremisina I. A. , Belov V. N. , Vollis Y. A. , Ispiriyan A. A. , Gridneva E. A. , Ismailova A. A. , Maltseva M. N. , Melnikova E. H. , Moiseeva Y N , Petrenko M. I. , Takhtamysheva M. M. , Titova T. S. , Khaidarova F. R. , Savenkova A. N. 
Published: August 2021

Aim Improvement of quality of life is one of the most important goals for the treatment of patients with chronic heart failure (CHF). This study searched for ways to increase the efficiency of CHF treatment based on parameters of quality of life in CHF patients during and after the treatment with exogenous phosphocreatine (EP).Material and methods The effect of a single course of EP treatment on quality of life of patients with functional class (FC) II-IV CHF with reduced or mid-range left ventricular ejection fraction was studied as a part of the all-Russia prospective observational study BYHEART. The presence of FC II-IV CHF and a left ventricular ejection fraction <50 % were confirmed by results of 6-min walk test (6MWT) and findings of echocardiography after stabilization of the background therapy.Results An interim data analysis showed that the course of EP treatment was associated with a significant improvement of quality-of-life indexes as determined by the Minnesota Living with Heart Failure Questionnaire (LHFQ) total score. These indexes significantly increased and remained at a satisfactory level for 6 mos. following completion of the treatment course. Also, the treatment significantly beneficially influenced the clinical condition of patients (heart failure severity scale), results of 6MWT, and the increase in left ventricular ejection fraction.Conclusion The conclusions based on results of the interim analysis should be confirmed by results of the completed study. Complete results are planned to be published in 2022.
Odpowiedzialność trajektorią w świat dobra
Authors: Rynio Alina 
Published: August 2021

Publikacja koncentruje uwagę wokół próby odpowiedzi na trzy zasadnicze pytania: 1) Czym jest odpowiedzialność i kiedy staje się trajektorią – prowadzącą w świat dobra? 2) Jakie warunki są niezbędne, aby taka odpowiedzialność zaistniała? 3) Jak jest rozumiane samo dobro i co kryje się w pojęciu szeroko rozumianego „świata dobra”? Odpowiadając na podstawie analizy reprezentatywnej literatury przedmiotowej, autorka przybliża samo pojęcie odpowiedzialności, jak i dobra oraz opisuje warunki niezbędne do ich zaistnienia. Wśród warunków niezbędnych do zaistnienia odpowiedzialności szczególne miejsce przypisuje integralnemu wychowaniu osoby.
THE BODY MASS INDEX (BMI) RELATED TO MENOPAUSE SYMPTOMS
Authors: Zulfi Olvinda Eka , Dwiningsih Sri Ratna , Krisnana Ilya 
Published: August 2021

AbstractBackground : Menopause is a natural period in a woman's life related to hormonal changes and is marked by the cessation of menstruation in the last 12 months and can cause a wide range of sometimes bothersome menopause symptoms. That menopause symptoms associated with several risk factors such as Body Mass Index (BMI) and knowledge. The study aims to identify the relationship of BMI and knowledge with menopause symptoms in the Shafa group Padang Petok Nagari Panti Selatan. Method : This research is analitic observational research with cross sectional approach. The sampling technique was carried out by total sampling consisting of 55 respondents with inclusion criteria menopause women aged 45-65 years who have not experienced dementia, have good awareness and willing to be respondents. Data were obtained by weighing, measuring height and filling out The Menopause Rating Scale to evaluate the severity of menopause-related symptoms by respondents. Afterwards the data was analyzed by the Spearman rho test to see the association between BMI and knowledge with menopause symptoms. Result : The research shows 65,4% respondents with high BMI, 72,7% with lacking of knowledge and 60% with severe menopause symptoms. The results of the Spearman rho test showed a relationship between BMI and menopause symptoms (p value = 0.000), but there is no relationship between knowledge of menopause and menopause symptoms (p= 0,450). Conclusion : BMI related to menopause symptoms. Menopause women must monitor their weight in an effort to prevent these complaints.