bluuebunny/crossref_metadata_2025_split huggingface dataset:
Market entry for wind energy: Strategic approaches for the original equipment manufacturer
Authors: Zwarteveen Jan Willem , Zawwar Imran , Angus Andrew 
Published: October 2021

AbstractWind energy is a valuable resource, but many developing and emerging economies (DEEs) are not utilizing the tremendous wind capacity available to them. This means there is a potential for wind turbine original equipment manufacturers (OEMs) to penetrate new markets to increase profits, and to contribute to Sustainable Development Goals. This article explores the potential triggers for wind energy diffusion and provides the basis for inclusive market entry strategies for wind power OEMs. Indications are that early wind energy path creation is driven by climate adaptation, vested interests in fossil fuels and hydropower, and the business case potential. A negative business case potential in many DEEs formed a substantial barrier. A shift to increased local value creation, collaboration with traditional power producers, and promoting wind for climate adaptation are key novel inclusive market entry strategies to open and develop new markets.
Counselling and reconciliation practices among the Oromo community
Authors: Abeshu Getachew , Urgessa Dinaol 
Published: October 2021

AbstractThe topics of counselling and reconciliation seem controversial in developing countries because of their intrigued relationship. Likewise, the goal and processes are in question across cultures. In this study, qualitative research approach employing a case study method was carried out with deliberately selected elder counsellors in the Oromo community. Data were gathered using interviews and observations in the field. The results indicated that reconciliation is concurrently practised with counselling, which is the most important instrument to manage differences and to calm everyone involved. It serves to maintain peace and stability between conflicting groups and kinship; saves lives and prevents destruction of property; assists in progressing community rules and regulations; and supports family challenges. The research also identified that processes, tools of operation and time to conduct vary between communities. In conclusion, the goal of counselling and reconciliation is to retain peace and stability through thorough discussion, self‐evaluation and redeeming processes. Equally, pre‐ and post‐counselling sessions in reconciliation are useful approaches cohesive with reality and truth‐seeking behaviours to settle disputes in the community.
Evaluation of Pomelo Seed Extracts as Natural Antioxidant, Antibacterial, Herbicidal Agents, and Their Functional Components
Authors: Ling Wei , Dai Tingrui , Zhang Jingyi , Liang Yan , Yin Wenyue , Zhong Balian , Zhang Jun 
Published: October 2021

AbstractPomelo seeds (PS) are important by‐product of pomelo fruits (Citrus grandis Osbeck). The value‐added utilization of PS remains highly challenged. This study aimed to investigate the utilization potential of PS as natural antioxidant, antibacterial, herbicidal agents, and their functional components. The ethanolic extract (EE) of PS and its four fractions as PEE (petroleum ether extract), AcOEtE (ethyl acetate extract), BTE (butanol extract), and WE (water extract), were prepared and biologically evaluated. BTE exhibited the best antioxidant activity among all these extracts, in both ABTS (2,2‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) diammonium salt) and FRAP (ferric reducing antioxidant power) assays. AcOEtE was superior to other extracts in herbicidal assay against both Festuca elata Keng (IC50 of 0.48 mg mL−1) and Amaranthus retroflexus L. (IC50 of 0.94 mg mL−1). Meanwhile, both AcOEtE and BTE demonstrated inhibitory effects against Bacillus subtilis, Escherichia coli, and Xanthomonas citri subsp. citri, with MIC ranging 2.5–5.0 mg mL−1. Furthermore, the primary chemical components involving naringin, deacetylnomilin, limonin, nomilin, and obacunone, were quantified in all these extracts. PCA (principal component analysis) suggested that naringin might highly contribute to the antioxidant activity of PS, and the herbicidal activity should be ascribed to limonoids. This study successfully identified AcOEtE and BTE as naturally occurring antioxidant, antibacterial, and herbicidal agents, showing application potential in food and cosmetics industries, and organic farming agriculture.
Colesevelam‐induced hypoglycaemia in a patient with type 1 diabetes mellitus
Authors: Pavlou Panagiotis , Koutroukas Vaios , Lissett Catherine , Smith Jamie C. 
Published: October 2021

AbstractColesevelam possesses antidiabetic properties, which could potentiate sulphonylurea or insulin‐induced hypoglycemia; clinically significant hypoglycemia, as a side effect to bile acid sequestrants, may be under‐recognized in clinical practice.
Diagnostic significance of fat globules in blood in fulminant‐type fat embolism syndrome
Authors: Asakage Ayu , Fujisawa Michiko , Takei Tetsuhiro , Kumagai Jiro 
Published: October 2021

AbstractFat globule detection in the blood in fat embolism syndrome (FES) diagnosis remains controversial. This case illustrates two life‐threatening, possibly FES‐related, episodes with dramatic increases in blood fat globule level. Future studies should aim at evaluating the significance of the quantitative changes in blood fat levels in diagnosing FES.
Primary leiomyosarcoma of the inferior vena cava: Is vascular reconstruction always necessary?
Authors: Kardoun Nizar , Bouzid Ahmed , Trigui Ayman , Rejab Haithem , Mohamed BenAmar , Rafik Mzali 
Published: October 2021

AbstractBoth MRI and CT scan can determine tumor size and its extension. PLV have a poor prognosis if surgical resection cannot be achieved. We recommend no reconstruction for type II PLV if venous contact is less than 180° or where the implantation base does not exceed one third of the vena cava.
Extraoral exanthem revealing Gianotti‐Crosti syndrome in a young child: A case report
Authors: Besbes Amira , Korbi Mouna , Besbes Faten , Elelmi Yamina 
Published: October 2021

AbstractWe reported a case of a 14‐month‐old girl with erythematous and papulovesicular pink to red lesions on the face, the upper and the lower limbs. The history and the morphological features confirmed the diagnosis of Gianotti‐Crosti syndrome.
Metastatic and locally aggressive BCC: Current treatment options
Authors: Casey Máire‐Caitlín , Pollock Roisín , Enright Rachel H , O'Neill James Paul , Shine Neville , Sullivan Paul , Martin Fiachra T , O'Sullivan Barry 
Published: October 2021

AbstractThe treatment of locally advanced and metastatic BCC presents a significant clinical challenge. Treatment options have evolved recently to include the use of hedgehog inhibitors Vismodigib and Sonidigib and immunotherapy with Cemiplimab.
Vesiculobullous disease with Cutaneous Systemic Lupus Erythematosus Treated by Rituximab: A case report
Authors: Mohammed Niamat Alla Wigdan , Mohamed Ali Ahmed Burhan , Adam Essa Mohammed Elmujtba , Abdalla Babker Atif Elhadi , Mohammed Elagib Elnour 
Published: October 2021

AbstractVesiculobullous lesions in systemic lupus erythematosus (SLE) are a rare cutaneous manifestation of cutaneous and/or systemic LE with variable presentation. The diagnosis of SLE‐associated vesiculobullous diseases remains challenging, due to the poorly defined similarities and nosology in immunohistopathological and clinical and features.
Pediatric intraosseous cranial myxoma: A case report and review of literature
Authors: Howser Lauren A. , Ye Michael J. , Boham Sampson , Fan Rong , Nelson Rick F. 
Published: October 2021

AbstractWhile intraosseous cranial myxoma is a rare pathology, it is important for providers to be aware of it, as early diagnosis and treatment is imperative for prognosis. Long‐term follow‐up is needed as high rates of recurrence have been documented.
Host‐Guest Systems on the Surface of Functionalized Superparamagnetic Iron Oxide Nanoparticles (SPIONs) Utilizing Hamilton Receptors and Cyanurate Derivative Molecules
Authors: Ali Muhammad , Kataev Evgeny , Müller Johannes , Park Hyoungwon , Halik Marcus , Hirsch Andreas 
Published: October 2021

AbstractThe study of hydrogen bonding interactions at the level of functionalized nanoparticles remains highly challenging and poorly explored area. In this work, superparamagnetic iron oxide nanoparticles (SPIONs) were orthogonally functionalized using receptors bearing multiple hydrogen bonding motifs. Pristine SPIONs were modified by wet chemical processes with Hamilton receptors (hosts), or cyanurate‐guest molecules linked to phosphonic acid moieties for monolayer functionalization. The modified surfaces were fully characterized and the number of attached ligands on the surface were determined. The host‐guest interactions on the interface of modified SPIONs were investigated by using UV‐Vis spectroscopic titrations. Functionalized SPIONs demonstrated two to three magnitudes stronger binding affinities as compared to the related molecular interactions in solution due to synergistic effects on complex surface environment. Higher supramolecular binding ratios of host‐guest interactions on the modified surface were emerged. These studies provide fundamental insights into supramolecular complexations on the surface at solid‐liquid interface systems with applications in engineered nanomaterials, nano‐sensing devices, and drug delivery systems.
Efficient preparation of (R)‐2‐(2,5‐difluorophenyl)pyrrolidine via a recycle process of resolution
Authors: Lv Xunlei , Chen Liang , Pan Jing , Meng Xue , Bi Siju , Liu Weiyuan , Zhou Ting , Lin Kuaile , Ye Deyong , Zhou Weicheng 
Published: October 2021

AbstractAn efficient preparation of (R)‐2‐(2,5‐difluorophenyl)pyrrolidine ((R)‐1) from the racemate based on a recycle process of resolution/racemization was described. In the process, the desired (R)‐1 was obtained by resolution with D‐malic acid in 95% EtOH. Meanwhile, the undesired (S)‐1 could be racemized in the presence of potassium hydroxide in DMSO. After three times of recycle process, the desired freebase (R)‐1 was obtained in a yield of 61.7% with excellent ee (98.4%).
Color appearance of color chips under light‐emitting diode lamps
Authors: Chitapanya Phubet , Phuangsuwan Chanprapha , Ikeda Mitsuo 
Published: October 2021

AbstractMany kinds of research have been undertaken on color constancy under various illuminations; however, not many people have studied this domain in the context of vivid colored light. In this article, 23 color chips were assessed using the elementary color‐naming method under 13 RGB‐LED illuminations of six hues as red, yellow, green, cyan, blue, and magenta. A total of 100 subjects participated in the study and reported that color chips of cyan, yellow, and green light were not good as compared to the others. This article also proposes an elementary color‐naming method as an alternative way to study and calculate color constancy index using the two rooms technique as extending experiment booth to get the color appearance of the color chip without adapting to the colored illumination. Our results suggested individual color appearance performance for each colored light which yellow, cyan, and green are not recommended as shown by poor area ratio and color constancy index.
Botnet attack detection in Internet of Things devices over cloud environment via machine learning
Authors: Waqas Muhammad , Kumar Kamlesh , Laghari Asif Ali , Saeed Umair , Rind Muhammad Malook , Shaikh Aftab Ahmed , Hussain Fahad , Rai Athaul , Qazi Abdul Qayoom 
Published: October 2021

SummaryWith the arrival of the Internet of Things (IoT) many devices such as sensors, nowadays can communicate with each other and share data easily. However, the IoT paradigm is prone to security concerns as many attackers try to hit the network and make it vulnerable. In this scenario, security concerns are the most important and to address them various models have been designed to overcome these security issues, but still there exist many emerging variants of botnet attacks such as Mirai, Persirai, and Bashlite that exploits the security breaches. This research article aims to investigate cyber security in the advent of B‐IDS, DDOS, and malware attacks. For this purpose, different machine learning algorithms, namely, support vector machine, naive Bayes, linear regression, artificial neural network, decision tree, random forest, the fuzzy classifier, K‐nearest neighbor, adaptive boosting, gradient boosting, and tree ensemble have been implemented for botnet attack detection. For performance measures, these algorithms have been tested on nine sensor devices over N‐BaIoT datasets to measure the security and accuracy of the intrusion detection system. The results show that the tree‐based algorithm achieved more than 99% accuracy which is quite higher as compared to other tested methods on the same sensor devices.
Effect of the Proton Pump Inhibitor Esomeprazole on the Systemic Exposure of Capecitabine: Results of A Randomized Crossover Trial
Authors: van Doorn Leni , Heersche Niels , de Man Femke M. , de Bruijn Peter , Bijl Ivo , Oomen‐de Hoop Esther , Eskens Ferry A. L. M. , van der Gaast Ate , Mathijssen Ron H. J. , Bins Sander 
Published: October 2021

Retrospective data suggest that gastric acid reduction by proton pump inhibitors (PPIs) impairs the dissolution and subsequent absorption of capecitabine, and thus potentially reduces the capecitabine exposure. Therefore, we examined prospectively the effect of esomeprazole on the pharmacokinetics of capecitabine. In this randomized crossover study, patients with cancer were assigned to 2 sequence groups, each consisting of 3 phases: capecitabine with esomeprazole administration 3 hours before (phase A), capecitabine alone (phase B), and capecitabine concomitant with cola and esomeprazole co‐administration 3 hours before (phase C). The primary end point was the relative difference (RD) in exposure to capecitabine assessed by the area under the plasma concentration‐time curve from zero to infinity (AUC0‐inf) and analyzed by a linear mixed effect model. Twenty‐two evaluable patients were included in the analysis. After esomeprazole, there was a 18.9% increase in AUC0‐inf of capecitabine (95% confidence interval (CI) −10.0% to 57.0%, P = 0.36). In addition, capecitabine half‐life was significantly longer after esomeprazole (median 0.63 hours vs. 0.46 hours, P = 0.005). Concomitant cola did not completely reverse the effects observed after esomeprazole (RD 3.3% (95% CI −16.3 to 27.4%, P = 1.00). Capecitabine exposure is not negatively influenced by esomeprazole cotreatment. Therefore, altered capecitabine pharmacokinetics do not explain the assumed worse clinical outcome of PPI‐cotreated patients with cancer.
Triple‐phase Boundary in Anion‐Exchange Membrane Reactor Enables Selective Electrosynthesis of Aldehyde from Primary Alcohol
Authors: Ido Yuto , Fukazawa Atsushi , Furutani Yuka , Sato Yasushi , Shida Naoki , Atobe Mahito 
Published: October 2021

AbstractOxidation of primary alcohol to the corresponding aldehyde remains a significant challenge, even with the state‐of‐the‐art chemistry. Here, a novel electrochemical system was developed for the exclusive production of aldehyde from primary alcohol using an anion‐exchange membrane (AEM) reactor. Oxidation proceeded on a gold catalyst under basic conditions, which largely enhanced the reaction rate. Despite the basic nature around the reaction sites, the oxidation of primary alcohols exclusively yielded the corresponding aldehyde, which was attributed to the unique three‐phase interfacial reaction sites in the AEM reactor. In addition to benzyl alcohol, the oxidation of allylic and aliphatic alcohols was also demonstrated. Comparison of constant potential electrolysis with the AEM reactor or a conventional batch‐type cell revealed the crucial role of the triple‐phase boundary for the selectivity of the oxidation of alcohol.
Development and analysis of three‐coil wireless charging system for electric vehicles
Authors: Kamalapathi Kuditi , Srinivasa Panugothu , Kumar Tyagi Vipul 
Published: October 2021

SummaryWireless charger has become a potential solution for charging electric vehicles (EVs) due to its intrinsic convenience and further scope of countering range anxiety issue. However, ground clearance of the EVs varies with the vehicle type, manufacturer, and so on, which reduces the power transfer efficiency (PTE) and power delivered to load (PDL) by the wireless charger. To overcome these limitations, this paper focused to revamp the design of a three‐coil wireless charging system through optimized size and position of intermediate coil (InC). Further, the system is tested for different loads at different input voltages, misalignment conditions, and distances for 100‐kHz frequency and compared with a two‐coil system under the same conditions. Angular misalignment of InC near the transmitter coil (TxC) (50‐mm gap) showed increased efficiency compared to other misalignment conditions. Three‐coil system results at different distances of InC from TxC showed that the maximum efficiency region shifted to different loads. Maximum efficiency for designed three‐coil was achieved when the InC was placed in the center between the TxC and RxC. Maximum efficiency for power transfer distance (D) of 150 and 200 mm obtained are 76% and 70% for 25Ω and 35Ω.
Imaging flow cytometry reveals a subset of TdT negative T‐ALL blasts with very low forward scatter on conventional flow cytometry
Authors: Rosenberg Carina A. , Bill Marie , Maguire Orla , Petersen Marianne A. , Kjeldsen Eigil , Hokland Peter , Ludvigsen Maja 
Published: October 2021

AbstractBackgroundStudies in T‐cell acute lymphoblastic leukemia (T‐ALL) have shown that leukemic blast populations may display immunophenotypic heterogeneity. In the clinical setting, evaluation of measurable residual disease during treatment and follow‐up is highly dependent on knowledge of the diversity of blast subsets. Here, we set out to evaluate whether variation in expression of the blast marker, TdT, in T‐ALL blasts could correspond to differences in morphometric features.MethodsWe investigated diagnostic bone marrow samples from six individual T‐ALL patients run in parallel on imaging flow cytometry (IFC) and conventional flow cytometry (CFC).ResultsGuided by the imagery available in IFC, we identified distinct TdTneg and TdTpos subpopulations with apparent differences in internal complexity. As TdTneg blasts predominantly displayed very low forward scatter (FSC) on CFC, these subsets were initially excluded from routine analysis as debris, elements of small diameter, apoptotic, and/or dead cells. However, IFC‐based morphometric analyses demonstrated that cell size and shape of TdTneg blasts were comparable to the TdTpos cells and without morphometric apoptotic hallmarks, supporting that the TdTneg subpopulation corresponded to T‐ALL blasts. Fluorescence in situ hybridization analyses substantiated the clinical relevance of TdTnegFSCvery‐low cells by retrieving known diagnostic cytogenetic abnormalities at comparable frequencies in purified TdTnegFSCvery‐low and TdTposFSCint subsets.ConclusionWe highlight this finding as knowledge of phenotypic heterogeneity is of crucial importance in the clinical setting for delineation and quantification of blast subpopulations of potential biological relevance. We argue that the IFC imagery may allow for visual verification and improvement of applied gating strategies.
In vitro metabolic profile of mexedrone, a mephedrone analog, studied by high‐ and low‐resolution mass spectrometry
Authors: Camuto Cristian , Guglielmelli Angelica , De‐Giorgio Fabio , de la Torre Xavier , Mazzarino Monica , Marti Matteo , Botrè Francesco 
Published: October 2021

AbstractMexedrone is a synthetic cathinone structurally related to mephedrone, which belongs to the class of N‐alkyl cathinone derivatives, whose metabolic profile has not been fully clarified yet. This study considers the in vitro phase I metabolism of mexedrone, to pre‐select the most appropriate marker(s) of intake. Mexedrone was incubated in the presence of either human liver microsomes or single recombinant CYP450 isoforms. The metabolic profile was outlined by ultra‐high‐performance liquid chromatography coupled to both high‐ and low‐resolution mass spectrometry. In detail, the phase I metabolic profile of mexedrone was initially defined by a time‐of‐flight analyzer, while the chemical structures of the detected metabolites and the potential presence of minor metabolites were subsequently studied by tandem mass spectrometry, using a triple quadrupole analyzer. The main phase I metabolic reactions were hydroxylation and N‐ and O‐dealkylation. The CYP450 isoforms most involved were CYP2C19, responsible for the formation of both hydroxylated and dealkylated metabolites, followed by CYP2D6 and CYP1A2, involved in the hydroxylation reactions only. Finally, a significant fraction of mexedrone unchanged was also detected. Based on this evidence, the most appropriate markers of intake are mexedrone unchanged and the hydroxylated metabolites.
Understanding Australian methylamphetamine drug markets through relational, temporal and spatial analyses
Authors: Popovic Ana , Morelato Marie , Baechler Simon , De Grazia Adrian , Tahtouh Mark , Roux Claude , Beavis Alison 
Published: October 2021

AbstractIn the area of illicit drugs, forensic case data have proven effective at detecting links between seizures and providing greater insights into illicit drug markets. This research explored the application of mathematical and statistical techniques to several chemical profiles of Australian methylamphetamine seizures. The main aim was to create and deliver a method that would expand the use of illicit drug profiling for strategic intelligence purposes, contributing to the fight against illicit drug trafficking. The use of comparison metrics and clustering analysis to determine links between existing illicit drug specimens and subsequent new specimens was evaluated and automated. Relational, temporal and spatial analyses were subsequently used to gain an insight into illicit drug markets. Relational analysis identified clusters of seizures central to the network. Temporal analysis then provided insights into the behaviour of distribution markets, specifically the emergence and extinction of certain clusters of seizures over time. Spatial analysis aided the understanding of the inter‐jurisdictional nature of illicit drug markets. These analyses allowed for the generation of strategic intelligence relating to when and where the Australian methylamphetamine illicit drug market was the most active. Additionally, the strategic level trends identified clusters of seizures that were worth investigating further. These clusters were explored through a case study, which exploited additional chemical profiling data to provide drug market knowledge at an operational level. In turn, the intelligence produced at various levels could allow relevant law enforcement agencies to take necessary measures in disrupting markets.