bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic performance of a Recombinant Polymerase Amplification Test—Lateral Flow (RPA-LF) for cutaneous leishmaniasis in an endemic setting of Colombia
Authors: Cossio Alexandra , Jojoa Jimena , Castro María del Mar , Castillo Ruth Mabel , Osorio Lyda , Shelite Thomas R. , Gore Saravia Nancy , Melby Peter C. , Travi Bruno L. 
Published: April 2021

Background
Control of cutaneous leishmaniasis by public health systems in the Americas relies on case identification and treatment. Point-of-care diagnostics that can be performed by health workers within or near affected communities could effectively bring the health system to the resource-limited sites providing early diagnosis and treatment, reducing morbidity and the burden of disease.

Methodology/principal findings
A cross-sectional study was undertaken to evaluate the diagnostic test performance of Isothermal Recombinase Polymerase Amplification (RPA) targeting Leishmania kinetoplast DNA, coupled with a lateral flow (LF) immunochromatographic strip, in a field setting and a laboratory reference center. Minimally invasive swab and FTA filter paper samples were obtained by community health workers and highly trained technicians from ulcerated lesions of > 2 weeks’ evolution from 118 patients’ ≥ 2 years of age in the municipality of Tumaco, Nariño. Extracted DNA was processed by RPA-LF at a reference center or in a primary health facility in the field. Evaluation was based on a composite “gold standard” that included microscopy, culture, biopsy and real-time polymerase chain reaction detection of Leishmania 18S rDNA. Standard of care routine diagnostic tests were explored as comparators.
Sensitivity and specificity of RPA-LF in the reference lab scenario were 87% (95%CI 74–94) and 86% (95%CI 74–97), respectively. In the field scenario, the sensitivity was 75% (95%CI 65–84) and specificity 89% (95%CI 78–99). Positive likelihood ratios in both scenarios were higher than 6 while negative likelihood ratios ranged to 0.2–0.3 supporting the usefulness of RPA-LF to rule-in and potentially to rule-out infection.

Conclusions/significance
The low complexity requirements of RPA-LF combined with non-invasive sampling support the feasibility of its utilization by community health workers with the goal of strengthening the diagnostic capacity for cutaneous leishmaniasis in Colombia.

Trial registration
ClinicalTrials.gov NCT04500873.
The Prognosis in Palliative care Study II (PiPS2): A prospective observational validation study of a prognostic tool with an embedded qualitative evaluation
Authors: Stone P. C. , Kalpakidou A. , Todd C. , Griffiths J. , Keeley V. , Spencer K. , Buckle P. , Finlay D. , Vickerstaff V. , Omar R. Z. ,   on behalf of the PiPS2 investigators’ group
Published: April 2021

Background
Prognosis in Palliative care Study (PiPS) models predict survival probabilities in advanced cancer. PiPS-A (clinical observations only) and PiPS-B (additionally requiring blood results) consist of 14- and 56-day models (PiPS-A14; PiPS-A56; PiPS-B14; PiPS-B56) to create survival risk categories: days, weeks, months. The primary aim was to compare PIPS-B risk categories against agreed multi-professional estimates of survival (AMPES) and to validate PiPS-A and PiPS-B. Secondary aims were to assess acceptability of PiPS to patients, caregivers and health professionals (HPs).

Methods and findings
A national, multi-centre, prospective, observational, cohort study with nested qualitative sub-study using interviews with patients, caregivers and HPs. Validation study participants were adults with incurable cancer; with or without capacity; recently referred to community, hospital and hospice palliative care services across England and Wales. Sub-study participants were patients, caregivers and HPs. 1833 participants were recruited. PiPS-B risk categories were as accurate as AMPES [PiPS-B accuracy (910/1484; 61%); AMPES (914/1484; 61%); p = 0.851]. PiPS-B14 discrimination (C-statistic 0.837) and PiPS-B56 (0.810) were excellent. PiPS-B14 predictions were too high in the 57–74% risk group (Calibration-in-the-large [CiL] -0.202; Calibration slope [CS] 0.840). PiPS-B56 was well-calibrated (CiL 0.152; CS 0.914). PiPS-A risk categories were less accurate than AMPES (p<0.001). PiPS-A14 (C-statistic 0.825; CiL -0.037; CS 0.981) and PiPS-A56 (C-statistic 0.776; CiL 0.109; CS 0.946) had excellent or reasonably good discrimination and calibration. Interviewed patients (n = 29) and caregivers (n = 20) wanted prognostic information and considered that PiPS may aid communication. HPs (n = 32) found PiPS user-friendly and considered risk categories potentially helpful for decision-making. The need for a blood test for PiPS-B was considered a limitation.

Conclusions
PiPS-B risk categories are as accurate as AMPES made by experienced doctors and nurses. PiPS-A categories are less accurate. Patients, carers and HPs regard PiPS as potentially helpful in clinical practice.

Study registration
ISRCTN13688211.
The impact of community led alternative rite of passage on eradication of female genital mutilation/cutting in Kajiado County, Kenya: A quasi-experimental study
Authors: Muhula Samuel , Mveyange Anthony , Oti Samuel Oji , Bande Martha , Kayiaa Hellen , Leshore Charles , Kawai David , Opanga Yvonne , Marita Enock , Karanja Sarah , Smet Eefje , Conradi Hilke 
Published: April 2021

Introduction
In Kenya, Female Genital Mutilation/Cutting (FGM/C) is highly prevalent in specific communities such as the Maasai and Somali. With the intention of curtailing FMG/C prevalence in Maasai community, Amref Health Africa, designed and implemented a novel intervention—community-led alternative rite of passage (CLARP) in Kajiado County in Kenya since 2009. The study: a) determined the impact of the CLARP model on FGM/C, child early and forced marriages (CEFM), teenage pregnancies (TP) and years of schooling among girls and b) explored the attitude, perception and practices of community stakeholders towards FGM/C.

Methods
We utilised a mixed methods approach. A difference-in-difference approach was used to quantify the average impact of the model with Kajiado as the intervention County and Mandera, Marsabit and Wajir as control counties. The approach relied on secondary data analysis of the Kenya Demographic and Health Survey (KDHS) 2003, 2008–2009 and 2014. A qualitative approach involving focus group discussions, in-depth interviews and key informant interviews were conducted with various respondents and community stakeholders to document experiences, attitude and practices towards FGM/C.

Results
The CLARP has contributed to: 1) decline in FGM/C prevalence, CEFM rates and TP rates among girls by 24.2% (p<0.10), 4.9% (p<0.01) and 6.3% (p<0.01) respectively. 2) increase in girls schooling years by 2.5 years (p<0.05). Perceived CLARP benefits to girls included: reduction in teenage marriages and childbirth; increased school retention and completion; teenage pregnancies reduction and decline in FGM/C prevalence. Community stakeholders in Kajiado believe that CLARP has been embraced in the community because of its impacts in the lives of its beneficiaries and their families.

Conclusion
This study demonstrated that CLARP has been positively received by the Maasai community and has played a significant role in attenuating FGM/C, CEFM and TP in Kajiado, while contributing to increasing girls’ schooling years. CLARP is replicable as it is currently being implemented in Tanzania. We recommend scaling it up for adoption by stakeholders implementing in other counties that practice FGM/C as a rite of passage in Kenya and across other sub Saharan Africa countries.
Prognostic tools or clinical predictions: Which are better in palliative care?
Authors: Stone P. , Vickerstaff V. , Kalpakidou A. , Todd C. , Griffiths J. , Keeley V. , Spencer K. , Buckle P. , Finlay D. , Omar R. Z. 
Published: April 2021

Purpose
The Palliative Prognostic (PaP) score; Palliative Prognostic Index (PPI); Feliu Prognostic Nomogram (FPN) and Palliative Performance Scale (PPS) have all been proposed as prognostic tools for palliative cancer care. However, clinical judgement remains the principal way by which palliative care professionals determine prognoses and it is important that the performance of prognostic tools is compared against clinical predictions of survival (CPS).

Methods
This was a multi-centre, cohort validation study of prognostic tools. Study participants were adults with advanced cancer receiving palliative care, with or without capacity to consent. Key prognostic data were collected at baseline, shortly after referral to palliative care services. CPS were obtained independently from a doctor and a nurse.

Results
Prognostic data were collected on 1833 participants. All prognostic tools showed acceptable discrimination and calibration, but none showed superiority to CPS. Both PaP and CPS were equally able to accurately categorise patients according to their risk of dying within 30 days. There was no difference in performance between CPS and FPN at stratifying patients according to their risk of dying at 15, 30 or 60 days. PPI was significantly (p<0.001) worse than CPS at predicting which patients would survive for 3 or 6 weeks. PPS and CPS were both able to discriminate palliative care patients into multiple iso-prognostic groups.

Conclusions
Although four commonly used prognostic algorithms for palliative care generally showed good discrimination and calibration, none of them demonstrated superiority to CPS. Prognostic tools which are less accurate than CPS are of no clinical use. However, prognostic tools which perform similarly to CPS may have other advantages to recommend them for use in clinical practice (e.g. being more objective, more reproducible, acting as a second opinion or as an educational tool). Future studies should therefore assess the impact of prognostic tools on clinical practice and decision-making.
Modelling knowledge, health beliefs, and health-promoting behaviours related to cardiovascular disease prevention among Malaysian university students
Authors: Lim Bee Chiu , Kueh Yee Cheng , Arifin Wan Nor , Ng Kok Huan 
Published: April 2021

BackgroundHealthy lifestyle habits formed during young adulthood may have a sustaining impact on health across later life. The current study aimed to test the theoretical model of factors (selected demographic variables, knowledge of heart disease, health belief related to cardiovascular disease (CVD), self-efficacy, cues to action, and screening intention) influencing health-promoting behaviours among Malaysian university students.MethodsIn a cross-sectional survey, the undergraduate students in Universiti Sains Malaysia were invited to complete the self-administered questionnaires. Participants were selected using a purposive sampling method. The proposed hypothesised model was analysed using a structural equation modelling with Mplus 7.3 program. A total of 788 (70.7% female) undergraduate students with a mean age of 20.2 (SD = 1.02) participated in the study. The primary outcome of knowledge, health beliefs, and health-promoting behaviours related to CVD were measured by questionnaires namely: Knowledge of Heart Disease, Health Beliefs Related to CVD, and Health Promoting Lifestyle Profiles-II.ResultsThe final hypothetical structural model showed a good fit to the data based on several fit indices: with comparative fit index (CFI) at .921, standardised root mean square residual (SRMR) at .037, and root mean square error of approximation (RMSEA) at .044 (90% CI: .032, .054). The final structural model supported 13 significant path estimates. These variables explained 12% of the total variance in health-promoting behaviours. Through perceived benefits, total knowledge had an indirect effect on health-promoting behaviours.ConclusionThe results suggest that perceived barriers, perceived benefits, family history of CVD, and screening intention enable young adults to engage in health-promoting behaviours.
«Potencia, no poder». De la fotografía como gesto de resistencia y migración
Authors: Cardona Elena 
Published: April 2021

Resumen
Hay imágenes poderosas y hay imágenes potentes. Todavía más, hay imágenes potentes que hacen resistencia al poder, que son acto y gesto de resistencia en sí mismas. Entre marzo y agosto del año 2017 la sociedad venezolana vivió uno de los períodos más sensibles de la ya prolongada crisis institucional del país, caracterizada visiblemente por cotidianas protestas de calle duramente reprimidas por las fuerzas de seguridad del Estado, fenómeno que fue nombrado por los medios de comunicación internacionales como la Primavera venezolana o la Rebelión de Abril. En un contexto hipermediatizado por las imágenes recirculadas por las redes sociales digitales y la prensa internacional, principalmente, destacan para mí los trabajos realizados por tres fotógrafos venezolanos: Gabriel Osorio, Vladimir Marcano Sifontes y Gabriel Méndez, cuyas fotografías testimonian experiencias traumáticas colectivas de resistencia al poder político en su propio «aquí y ahora» contingente, y articulan sus reflexiones desde el diálogo con ese otro sin nombre (el venezolano común, anónimo) en imágenes potentes que se tornan gestos de resistencia y migración.
Clarice Lispector y la desistencia de ser
Authors: Villalobos-Ruminott Sergio 
Published: April 2021

Resumen
A partir de una de las últimas novelas de la escritora brasileña, Clarice Lispector, A hora da estrela (1977), y de la problematización de la relación entre literatura, representación y pobreza, este trabajo intenta dos cosas: (1) mostrar el complejo mecanismo utilizado por Lispector en la elaboración de su novela, como un trabajo de des-narrativización que interrumpe el proceso representacional desde una elaboración minimalista de la trama y del personaje; y (2) mostrar cómo, a partir de dicha presentación de la vida precaria de su protagonista, Macabea, también refe-rida como la nordestina, se hace posible una nueva relación entre literatura, crítica e historia.
Pemantauan Kualitas Udara Kota Tegal (Studi Kasus : Kecamatan Tegal Selatan, Kecamatan Tegal Barat, Kecamatan Tegal Timur)
Authors: Pradifan Andika , Widayat Widayat , Suprihanto Agus 
Published: April 2021

Pengelolaan kualitas udara dan pengendalian pencemaran udara harus dilakukan untuk menjaga kelestarian dan keberlangsungan kehidupan. Pengelolaan dan pengendalian pencemaran udara dapat dilaksanakan dengan melakukan pemantauan kualitas udara. Hasil dari pemantauan kualitas udara ambien selanjutnya digunakan untuk perhitungan IKU. Indeks Kualitas Udara/IKU merupakan salah satu instrumen yang dapat digunakan untuk melakukan penilaian kualitas udara secara sederhana dengan menggunakan beberapa parameter terpilih. Indeks Standar Pencemar Udara/ISPU, Parameter yang digunakan untuk menentukan ISPU yaitu Sulfur Dioksida (SO2), Nitrogen Dioksida (NO2), Oksidan (O3), Total Partikel (TSP), Karbon Monoksida (CO), Amoniak (NH3), Hidrogen Sulfida (H2S), Weather Station (Suhu Udara, Tekanan Udara, Kelembaban Udara), Arah dan Kecepatan Angin, GPS (Koordinat Lokasi), Tingkat Kebisingan, dan PM10. Sedangkan untuk perhitungan Indeks Kualitas Udara menggunakan 2 parameter utama yaitu Nitrogen Oksida (NOx) dan Sulfur Oksida (SOx). Pengambilan sampel udara di Kota Tegal menggunakan alat High Volume Air Sampler (HVAS) dengan lama pengambilan selama 24 jam. Lokasi yang digunakan untuk pengambilan contoh kualitas udara ambien terletak di Jl. Dr. Cipto Mangunkusumo untuk pemantauan transportasi. Sedangkan untuk pemantauan kualitas udara dengan metode passive sampler memerlukan waktu selama 14 hari. Lokasi yang dipilih mewakili transportasi, kawasan permukiman, kawasan industri, kawasan perkantoran dan kawasan perdagangan. Pengambilan sampel kualitas udara ambien selama 24 jam digunakan untuk menghitung Nilai Indeks Standar Pencemar Udara (ISPU). Nilai ISPU pada lokasi pemantauan di Jl. Dr. Cipto Mangunkusumo (Terminal Kota Tegal) masing masing yaitu : SO2 sebesar 21,25, CO sebesar 10, NO2 sebesar 48, O3 sebesar 22,92 dan PM10 sebesar 40. Seluruh parameter termasuk dalam rentang 0 – 50 dengan kategori baik.
Board Level Employee Representation and Tax Avoidance in Europe
Authors: Vitols Sigurt 
Published: April 2021

AbstractIn part due to recent disclosures of large-scale tax evasion (e.g. Panama Papers), corporate tax avoidance has become a prominent public policy issue around the world. An increasing amount of research on this topic has focused on identifying the determinants of tax avoidance at the company and country level. Many newer studies examine differences in corporate governance as one of these determinants. However, this literature almost entirely neglects the role of board level employee representation (BLER), despite the fact that this form of ‘stakeholder governance’ is widespread in Europe. This paper addresses this gap in the literature by examining the relationship between BLER and tax avoidance at the company level. Two mechanisms are identified through which BLER might influence corporate tax behavior: 1) reduction in agency costs through monitoring and 2) the voting power of workers as board members to enter into coalitions with management and/or shareholders. Based on a sample of 2343 European listed companies between 2012 and 2017, this paper shows that companies with BLER have a higher effective tax rate (ETR) than companies without workers on the board. The analysis suggests that the ability to form coalitions through voting power is a more significant channel for influencing tax behavior than the monitoring mechanism. The policy implications are that governments should consider ‘stakeholder governance’ such as BLER as one measure supporting their efforts to combat tax avoidance.
Home Production and Leisure during the COVID-19 Recession
Authors: Leukhina Oksana , Yu Zhixiu 
Published: April 2021

Abstract
Between the months of February and April of 2020, average weekly market hours in the U.S. dropped by 6.25, meanwhile 36% of workers reported switching to remote work arrangements. In this paper, we examine implications of these changes for the time allocation of different households, and on aggregate. We estimate that home production activity increased by 2.65 h a week, or 42.4% of lost market hours, due to the drop in market work and rise in remote work. The monthly value of home production increased by $39.65 billion – that is 13.55% of the concurrent $292.61 billion drop in monthly GDP. Although market hours declined the most for single, less educated individuals, the lost market hours were absorbed into home production the most by married individuals with children. Adding on the impact of school closures, our estimate of weekly home production hours increases by as much as 4.92 h. The increase in the value of monthly home production between February and April updates to $73.57 billion. We also report the estimated impact of labor markets and telecommuting on home production for each month in 2020.
Role of vasodilation in liver regeneration and health
Authors: Große-Segerath Linda , Lammert Eckhard 
Published: April 2021

Abstract
Recently, we have shown that an enhanced blood flow through the liver triggers hepatocyte proliferation and thereby liver growth. In this review, we first explain the literature on hepatic blood flow and its changes after partial hepatectomy (PHx), before we present the different steps of liver regeneration that take place right after the initial hemodynamic changes induced by PHx. Those parts of the molecular mechanisms governing liver regeneration, which are directly associated with the hepatic vascular system, are subsequently reviewed. These include β1 integrin-dependent mechanotransduction in liver sinusoidal endothelial cells (LSECs), triggering mechanically-induced activation of the vascular endothelial growth factor receptor-3 (VEGFR3) and matrix metalloproteinase-9 (MMP9) as well as release of growth-promoting angiocrine signals. Finally, we speculate how advanced age and obesity negatively affect the hepatic vasculature and thus liver regeneration and health, and we conclude our review with some recent technical progress in the clinic that employs liver perfusion. In sum, the mechano-elastic properties and alterations of the hepatic vasculature are key to better understand and influence liver health, regeneration, and disease.
Comparative study of thermoplastic liner materials with regard to mechanical and permeation barrier properties before and after cyclic thermal aging
Authors: Backens Simon , Siering Jan , Schmidt Stefan , Glück Nikolai , Flügge Wilko 
Published: April 2021

Abstract
Lightweight pressure vessels of type IV for hydrogen storage consist of a thermoplastic inner liner, commonly from polyethylene or polyamide. The liner is the permeation barrier against the compressed gas and must prevent the formation of cracks, also after temperature changes, for example after refueling processes. In the present work high-density polyethylene, cross-linked polyethylene, polyamide 6 and polyamide 12 were characterized by tensile tests, single notch impact tests and permeations measurements before and after a cyclic thermal aging process. The aging only lead to slight changes of mechanical properties due to post-crystallization, but to a significant decrease of permeation properties. This decrease was contributed to weakened, amorphous regions where chain splitting occurred. Considerable differences in properties resulted from different peroxide cross-linking times of polyethylene at the same temperature. A longer holding time at 200 °C led to an improvement in impact strength by a factor of more than three. However, the permeation properties decreased by about 50 %, indicating that peroxide cross-linking in the melt inhibited the formation of crystalline regions.
Structure, electronic and optical properties of chalcopyrite-type nano-clusters XFeY2 (X=Cu, Ag, Au; Y=S, Se, Te): a density functional theory study
Authors: Ranjan Prabhat , Surolia Praveen K. , Chakraborty Tanmoy 
Published: April 2021

Abstract
Iron-based chalcopyrite materials have diverse applications in solar cells, spintronic, thermoelectric devices, LEDs and medical sciences. In this report we have studied structure, electronic and optical properties of chalcopyrite-type nano-cluster XFeY2 (X=Cu, Ag, Au; Y=S, Se, Te) systematically by using Density Functional Theory (DFT). Our computed HOMO-LUMO energy gap of XFeY2 is in the range of 1.568–3.982 eV, which endorses its potential application in optoelectronic devices and solar cells. The result shows that chalcopyrite-type material AuFeS2 having a star-type structure with point group C2v and sextet spin multiplicity, is the most stable cluster with HOMO-LUMO energy gap of 3.982 eV. The optical properties viz. optical electronegativity, refractive index, dielectric constant, IR and Raman activity of these nano-clusters are also investigated. The result exhibits that HOMO-LUMO energy gap of XFeY2 along with optical electronegativity and vibrational frequency decreases from S to Se to Te, whereas refractive index and dielectric constant increases in the reverse order.