bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological evaluation of anal canal wound healing after combined operations for combined anorectal pathology
Authors: Balytskyy V.V. 
Published: December 2021

The urgency of the problem of postoperative wound healing after combined operations for combined pathology of the anal canal and rectum is quite high and contributes to the introduction into the practice of coloproctologists of new modern surgical technologies for the treatment of this pathology. The aim of the study was to conduct a comparative morphological assessment of postoperative wound healing in patients with combined pathology of the anal canal and rectum after combined operations using modern high-frequency electrosurgical and radiosurgical technologies. The results of surgical treatment of 689 patients with combined pathology of the anal canal and rectum using high-frequency electrosurgery and radiowave surgery with morphological assessment of wound healing on 3, 5, 7, 14, 21 days of the postoperative period, which were divided into 4 study groups. Using of “Surgitron” and “KLS Martin” devices for the treatment of patients with combined pathology of the anal canal and rectum was accompanied by the formation of the thinnest layers of coagulation necrosis in tissues with a depth of 0.189±0.085 mm and 0.194±0.090 mm respectively and as result patients of the first and fourth study groups had the shortest duration of inpatient treatment, which was 3-5 days and the average time of wound healing, which was 14-15 days. Patients in these study groups had the lowest inflammatory neutrophil reaction in postoperative wounds on day 3, which rapidly disappeared by day 5, on days 7-14 they had active reparative processes with the appearance of fibroblasts and connective tissue fibers, and on 21 day squamous epithelial cells, which indicated the processes of active epithelialization of wounds. The effect on the tissues of the devices “EFA” and “ERBE ICC 200” was deeper than in the above groups, forming a layer of coagulation tissue necrosis with a depth of 0.208±0.097 mm and 0.302±0.107 mm respectively, which was accompanied by patients of the third and second study groups with longer terms of inpatient treatment, which amounted to 5-7 days and increase the duration of wound healing, which amounted to 16-19 days. Patients in the 2nd and 3rd study groups showed a more pronounced inflammatory neutrophilic reaction in postoperative wounds on the 3rd day, which did not disappear until the 5th day and in half of the cases the presence of a significant number of segmental neutrophils and bacterial accumulations persisted. On days 7-14 they had weak reparative processes with the appearance of single fibroblasts and a small number of connective tissue fibers and on the 21st day single squamous epithelial cells, which indicated slow processes of wound epithelization. Using of radio-wave surgery and high-frequency electrosurgery devices promotes active epithelialization of tissues preventing scar strictures of the anal canal and improves the rehabilitation of patients in the postoperative period.
Anatomy of the L5 nerve root in the pelvis for safe sacral screw placement: a cadaveric study
Authors: Tamagawa Shota , Okuda Takatoshi , Nojiri Hidetoshi , Sato Tatsuya , Momomura Rei , Ohara Yukoh , Hara Takeshi , Ishijima Muneaki 
Published: December 2021

OBJECTIVE
Previous reports have focused on the complications of L5 nerve root injury caused by anterolateral misplacement of the S1 pedicle screws. Anatomical knowledge of the L5 nerve root in the pelvis is essential for safe and effective placement of the sacral screw. This cadaveric study aimed to investigate the course of the L5 nerve root in the pelvis and to clarify a safe zone for inserting the sacral screw.

METHODS
Fifty-four L5 nerve roots located bilaterally in 27 formalin-fixed cadavers were studied. The ventral rami of the L5 nerve roots were dissected along their courses from the intervertebral foramina to the lesser pelvis. The running angles of the L5 nerve roots from the centerline were measured in the coronal plane. In addition, the distances from the ala of the sacrum to the L5 nerve roots were measured in the sagittal plane.

RESULTS
The authors found that the running angles of the L5 nerve roots changed at the most anterior surface of the ala of the sacrum. The angles of the bilateral L5 nerve roots from the right and left L5 intervertebral foramina to their inflection points were 13.77° ± 5.01° and 14.65° ± 4.71°, respectively. The angles of the bilateral L5 nerve roots from the right and left inflection points to the lesser pelvis were 19.66° ± 6.40° and 20.58° ± 5.78°, respectively. There were no significant differences between the angles measured in the right and left nerve roots. The majority of the L5 nerves coursed outward after changing their angles at the inflection point. The distances from the ala of the sacrum to the L5 nerve roots in the sagittal plane were less than 1 mm in all cases, which indicated that the L5 nerve roots were positioned close to the ala of the sacrum and had poor mobility.

CONCLUSIONS
All of the L5 nerve roots coursed outward after exiting the intervertebral foramina and never inward. To prevent iatrogenic L5 nerve root injury, surgeons should insert the S1 pedicle screw medially with an angle > 0° toward the inside of the S1 anterior foramina and the sacral alar screw laterally with an angle > 30°.
The value aspect of human development in Russia
Authors: Sobolev Eduard 
Published: December 2021

The article examines how the moral values inherent to human-oriented economy are being shaped in actual Russian society.
For this purpose, the author analyzes the peculiarities and contradictions of the value aspect that were characteristic of the national human potential during the Soviet period as compared to the values of modern Russians.
An assessment is made of feasibility and prospects for partial regeneration of the Soviet value system including non-acquisitiveness, disapproval of social inequality, respect for education, and striving for challenging job.
Research of Ancient Ukrainian Sculpture in the Works of Kyiv Circles of the Early XX Century
Authors: Udris Iryna 
Published: December 2021

Purpose of research. The need for a thorough scientific and theoretical consideration and generalization of the formation of systematic knowledge about the national forms of our art at the leading stages of historical development, is gaining relevance in modern domestic science of art. Among other things, it requires the study of the achievements of scientists in the study of national creative heritage in the field of sculpture of Kievan Rus and the Cossack times during the formation of scientific art history. The article is devoted to the process of formation of the concept of evolution of forms of sculpture of the old princely years and the Cossack era in the works of specialists of the early twentieth century.
The research methodology is based on a comprehensive historical and cultural approach, a systematic method, synchronous analysis of publications of one time period, structural analysis. This methodology allows us to consider the gradual formation of scientific views on the characteristic national differences and the direction of evolution of Ukrainian art of this period in the broader international context of artistic development.
The scientific novelty of the results is to determine the process of formation of objective ideas about the formal and semantic features, distinctive features and high artistic level of monuments of Ukrainian sculpture from ancient times to the end of the Cossack era based on analysis of publications of various trends of leading experts of the late XIX – XX centuries .: D. Ainalova, E. Redina, E. Kuzmina, F. Ernst, M. Makarenko, K. Shirotsky, S. Yaremich, V. Modzalevsky, F. Schmidt, devoted to the study of this branch of ancient Ukrainian art and in the context of the characteristics of the general development of fine arts, and as an independent subject of research. Conclusions. Ukrainian science of art of the early twentieth century. has achieved undeniable success in the study of national forms of domestic sculpture of ancient Slavic times, Kievan Rus and the seventeenth – eighteenth centuries. as the period of the highest prosperity. The considered material testifies to the high professional level of formation of the substantiated scientific concept of national self-sufficiency of ancient Ukrainian sculpture as an important component of the general art process at various stages of its development.
The effects of non-Newtonian blood modeling and pulsatility on hemodynamics in the food and drug administration’s benchmark nozzle model
Authors: Good Bryan C. 
Published: December 2021

BACKGROUND: Computational fluid dynamics (CFD) is an important tool for predicting cardiovascular device performance. The FDA developed a benchmark nozzle model in which experimental and CFD data were compared, however, the studies were limited by steady flows and Newtonian models. OBJECTIVE: Newtonian and non-Newtonian blood models will be compared under steady and pulsatile flows to evaluate their influence on hemodynamics in the FDA nozzle. METHODS: CFD simulations were validated against the FDA data for steady flow with a Newtonian model. Further simulations were performed using Newtonian and non-Newtonian models under both steady and pulsatile flows. RESULTS: CFD results were within the experimental standard deviations at nearly all locations and Reynolds numbers. The model differences were most evident at Re = 500, in the recirculation regions, and during diastole. The non-Newtonian model predicted blunter upstream velocity profiles, higher velocities in the throat, and differences in the recirculation flow patterns. The non-Newtonian model also predicted a greater pressure drop at Re = 500 with minimal differences observed at higher Reynolds numbers. CONCLUSIONS: An improved modeling framework and validation procedure were used to further investigate hemodynamics in geometries relevant to cardiovascular devices and found that accounting for blood’s non-Newtonian and pulsatile behavior can lead to large differences in predictions in hemodynamic parameters.
PERSPEKTIF FETHULLAH GÜLEN TENTANG DIALOG DAN TOLERANSI SEBAGAI RESOLUSI KONFLIK
Authors: Setiadi Ozi 
Published: December 2021

Konflik menjadi sesuatu yang tidak dapat dihindari bila tidak ada kesepahaman dan saling pengertian terhadap sebuah permasalahan. Ini kemudian memunculkan berbagai teori yang dicetuskn oleh para cendekiawan berkaitan dengan upaya yang harus dilakukan oleh masyarakat guna menyelesaikan konflik tersebut. Tulisan ini menjelaskan tentang bagaimana perspektif Fethullah Gulen sebagai sosok yang cinta damai dalam mengembangkan dialog dan toleransi sebagai resolusi konflik. Gulen berpendapat bahwa dialog dan toleransi bagaikan dua sisi mata uang yang tidak dapat dipisahkan. Dialog menjadi media yang menjembatani kerjasama peradaban, persaudaraan dan saling kesepahaman antara satu dengan lainnya, serta menghargai atas nilai-nilai yang diyakini bersama. Dialog menjadi sebuah bentuk yang menunjukkan kemoderatan yang tidak eksklusif dan terbuka terhadap pendapat berbagai kalangan. Sedangkan toleransi menjadi media yang sangat penting, bila sebuah dialog tidak menghasilkan kesepakatan atau kesepahaman, maka toleransi adalah jalan yang terbaik. Ini disebabkan toleransi menjadi sebuah cara untuk menahan diri dari terjadinya sebuah konflik. Dialog dan toleransi, meski kehadirannya sangat penting guna menciptakan perdamaian, namun hal ini juga memiliki hambatan khususnya bagi umat Muslim. Hambatan tersebut menurut Gṻlen diantaranya adalah ketidakpahaman umat Muslim itu sendiri dengan Islam saat ini, selain ingatan kolektif historis umat non Muslim, Kristen, tentang tragedi berdarah yang menimpa mereka atas perlakuan umat Muslim.
A Novel LysR Family Factor STM0859 is Associated with The Responses of Salmonella Typhimurium to Environmental Stress and Biofilm Formation
Authors: MA ZHONGMEI , LI NA , NING CHENGCHENG , LIU YUCHENG , GUO YUN , JI CHUNHUI , ZHU XIAOZHEN , MENG QINGLING , XIA XIANZHU , ZHANG XINGXING , CAI XUEPENG , CAI KUOJUN , JUN QIAO 
Published: December 2021

Abstract

Salmonella enterica subsp. enterica serovar Typhimurium (ST) is an intracellularly parasitic bacterium. This zoonotic pathogen causes food poisoning and thus imposes a severe threat to food safety. Here, to understand the regulatory roles of the novel transcription factor STM0859 on the response of ST to environmental stress and biofilm formation, the STM0859 gene-deficient strain and the complementation strain ΔSTM0859/STM0859 were generated, respectively. Then, its capacity of responding to environmental stresses and biofilm (BF) formation ability under different stresses, including acid, alkali, high salt, cholate, and oxidative stresses was tested. We further analyzed the interaction between the STM0859 protein and the promoter of the acid stress response-related gene rcsB by performing an electrophoresis mobility shift assay (EMSA). The results showed that acid resistance and BF formation capacities of ST-ΔSTM0859 strain were significantly weaker, as compared with those of Salmonella Typhimurium SL1344 (ST-SL1344) wild strain (p < 0.01). Quantitative qRT-PCR analysis showed that the expression levels of acid stress and BF formation-related genes, rcsB and rpoS, of ST-ΔSTM0859 strain were significantly reduced at the transcription levels, while the transcription levels of these genes were fully restored in complementation strain ST-ΔSTM0859/STM0859. The results of EMSA showed that STM0859 was capable of binding the promoter DNA fragments of the rcsB gene, suggesting that STM0859 can promote the transcription of the rcsB gene through interaction with its promoter, thereby exerting an indirectly regulatory role on the adaptive responses to acid stress and BF formation of ST. This study provided new insights into the regulatory mechanisms of the LysR family factors on the tolerances of ST under adverse environmental stresses.
Використання можливостей засобів імітаційного моделювання бойових дій у ході практичної підготовки органів військового управління
Authors: Заїка Людмила , Лавринчук Олександр , Крайнов Валерій 
Published: December 2021

Сучасні тенденції розвитку інформаційно-комунікаційних технологій, зокрема в середовищі засобів імітаційного моделювання військового призначення, світовий досвід їх використання в оперативній і бойовій підготовці військ створюють сприятливі умови для розвитку різних аспектів їх використання. У статті авторами розглянуто класифікацію таких засобів, обґрунтовано використання можливостей засобів імітаційного моделювання бойових дій щодо розвитку інтелектуальних, емоційно-вольових якостей військовослужбовців в умовах навчально-бойової обстановки для підвищення рівня їх навченості.
Ґрунтуючись на результатах проведених досліджень, досвіді використання сучасного засобу імітаційного моделювання бойових дій JCATS (Joint Conflict and Tactical Simulation) у ЗС України протягом останніх років, авторами досліджено шляхи використання результатів моделювання для оцінювання практичної складової навченості органів військового управління вже на одному із етапів підготовки органів управління бригад під час командно-штабних навчань базового етапу бойової підготовки Сухопутних військ ЗС України. Керуючись зазначеними методиками проведення оцінювання та отриманими у ході імітаційного моделювання на JCATS результатами (кількісними, результатами спостереження посередників, експертів тощо) автори розглядають можливість отримання кількісної оцінки рівня навченості органу військового управління.
Potensi Geologi Daerah Banten dan Sekitarnya Berdasarkan Analisis Data Anomali Gayaberat
Authors: Ervan M , Subagio Subagio 
Published: December 2021

Potensi geologi daerah Banten dan sekitarnya dianalisis berdasarkan interpretasi anomali gayaberat, baik potensi positif (sumberdaya mineral) maupun potensi negatif (kebencanaan geologi). Data anomali gayaberat yang digunakan untuk analisis potensi tersebut berupa anomali Bouguer dan anomali sisa. Kedua pola anomali ini di beberapa lokasi mempunyai hubungan langsung yang dapat dianalisis keterikatannya, sehingga memberikan pemahaman tentang hubungan struktur geologinya. Beberapa contoh, seperti Cekungan Jakarta dan Cekungan Ujung Kulon (merupakan bagian dari potensi geologi yang positif) dapat dianalisis dari kedua anomali di atas. Contoh lainnya adalah struktur geologi sesar geser (merupakan bagian dari potensi geologi negatif) berarah hampir baratlaut-tenggara. Sesar ini dapat diamati dari pola anomali Bouguer dan pola anomali sisa. Oleh sebab itu, dapat disimpulkan bahwa struktur geologi yang membentuk fenomena tersebut merupakan struktur dalam yang menerus hingga ke permukaanKatakunci: Anomali gayaberat, Cekungan Jakarta, Cekungan Ujung Kulon,Â potensi negatif, potensi positif,Â Â sesar geser.
Influence of combined use of gas-liquid peeling and PDT on quality of life of patients with visible signs of involutive skin changes
Authors: Surkichin S. I. , Kholupova L. S. 
Published: December 2021

Objective of the study. To develop a questionnaire to determine the quality of life of a patient with visible signs of involutive skin changes. To determine the effect of the combined use of gas-liquid peeling and PDT on the quality of life of patients with visible signs of involutive skin changes.Materials and methods. The study involved 50 patients aged 35 to 45 years. The state of the emotional sphere was assessed before and after the course of treatment using the following methods: a scale for assessing discomfort; ‘The Scale of States’ methodology by А. B. Leonova, Hospital Anxiety and Depression Scale (HADS), Dermatological Life Quality Index (DLQI). The condition was assessed before and after treatment (gas-liquid peeling and photodynamic therapy).Results. The use of the questionnaire developed by us made it possible to determine the index for assessing the quality of life in persons with agerelated skin changes and to reveal the influence of the latter on the emotional sphere and behavior of the respondents. A clear positive trend was observed when comparing indicators of discomfort, anxiety, depression, quality of life. The data obtained make it possible to recommend an assessment of the dermatological index of the quality of life in patients with age-related skin changes as a criterion for the effectiveness of the therapy, and also focus on the need for further study and correction of factors that cause deterioration in life in this category of women.
Balanoposthitis: issues of classification, diagnosis and approaches to therapy
Authors: Ignatovsky A. V. 
Published: December 2021

Objective. To present a variant of the modern classification of the processes occurring with lesions of the genitals, to draw specialists’ attention to the peculiarities and variety of causes leading to inflammation of the glans and foreskin, as well as to discuss topical issues of external therapy of balanopostitis.Material and methods. Data from modern studies and clinical guidelines were used in the preparation of the publication.Results. The variety of variants of lesions of the glans and foreskin can be due to a number of reasons and can be either an independent local process or a fragment of dermatosis, where it is possible to be affected in the form of balanoposthitis. Also, when examining and selecting therapy options, it is important to consider the possible role of microorganisms, whose spectrum as a cause of balanoposthitis varies from aerobic and anaerobic, to viral and fungal microflora. Treatment approaches are determined by the etiological factors.Conclusions. Balanoposthitis is a heterogeneous group of nosologies. The choice of treatment is based on the identified cause or empirically when possible. External therapy and hygiene constitute an essential part of treatment. When choosing drugs for topical glucocorticosteroids, preferenceshould be given to drugs with a high therapeutic index and low atrophogenic potential. Dysplastic processes of the penis are associated with human papillomavirus infection, the treatment of which can be both conservative and destructive.
Finding at dermatologist’s appointment: linear porokeratosis
Authors: Manturova N. E. , Rodina A. L. 
Published: December 2021

The article deals with the epidemiology, pathomorphological picture, trigger factors of development, clinical manifestations and forms, diagnosis, and peculiarities of treatment of linear porokeratosis. A clinical case is presented.Purpose of the article. To consider the clinical manifestations and peculiarities of the course of porokeratosis, paying special attention to linear porokeratosis and its management tactics.Material and methods. The article presents a clinical case of linear porokeratosis. The analysis of medical records was carried out. The forms of porokeratosis, clinical manifestations, peculiarities of diagnosis and approaches to the treatment of porokeratosis in modern conditions are considered.Results. This clinical case demonstrates the difficulty of making a diagnosis of linear porokeratosis. The diagnosis was made based on the results of histological examination of biopsy material. A tactic for the management of the patient was developed.Conclusions. Porokeratosis is a rare skin disease with a wide range of clinical variants, which is important for clinicians to know in order to make a correct diagnosis and avoid errors in diagnosis. The clinical manifestations of the disease are varied, with localized, disseminated, and rash forms.
IL-18-Mediated SLC7A5 Overexpression Enhances Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells via the c-MYC Pathway
Authors: Ni Feifei , Zhang Tao , Xiao Wanan , Dong Hong , Gao Jian , Liu YaFeng , Li Jianjun 
Published: December 2021

Objective: To investigate the role of IL-18 in the regulation of osteogenic differentiation in human bone marrow mesenchymal stem cells (hBMSCs).Methods: To assess whether IL-18 affects the osteogenic differentiation of hBMSCs through the c-MYC/SLC7A5 axis, IL-18 dose-response and time-course experiments were performed to evaluate its impact on osteogenic differentiation. To confirm osteogenic differentiation, alizarin red staining calcium measurement were performed. RT-qPCR and western blotting were used to determine the expression levels of bone-specific markers ALP, RUNX2, and BMP2, as well as those of SLC7A5 and c-MYC. Furthermore, SLC7A5 and c-MYC expression was evaluated via immunofluorescence. To elucidate the roles of SLC7A5 and c-MYC in osteoblast differentiation, cells were transfected with SLC7A5 or c-MYC siRNAs, or treated with the SLC7A5-specific inhibitor JPH203 and c-MYC-specific inhibitor 10058-F4, and the expression of SLC7A5, c-MYC, and bone-specific markers ALP, RUNX2, and BMP2 was assessed.Results: Our results demonstrated that IL-18 increased calcium deposition in hBMSCs, and upregulated the expression of SLC7A5, c-MYC, ALP, RUNX2, and BMP2. Silencing of SLC7A5 or c-MYC using siRNA reduced the expression of ALP, RUNX2, and BMP2, while IL-18 treatment partially reversed the inhibitory effect of siRNA. Similar results were obtained by treating hBMSCs with SLC7A5 and c-MYC specific inhibitors, leading to significant reduction of the osteogenesis effect of IL-18 on hBMSCs.Conclusion: In conclusion, our results indicate that IL-18 promotes the osteogenic differentiation of hBMSCs via the SLC7A5/c-MYC pathway and, therefore, may play an important role in fracture healing. These findings will provide new treatment strategies for delayed fracture healing after splenectomy.