bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventing Posttraumatic Stress Disorder Following Childbirth: A Systematic Review and Meta-Analysis
Authors: Dekel S , Papadakis JE , Quagliarini B , Pham CT , Pacheco-Barrios K , Hughes F , Jagodnik KM , Nandru R 
Published: February 2025

(Am J Obstet Gynecol. 2024; 230:6p610–641.e14. doi:10.1016/j.ajog.2023.12.013)
Posttraumatic stress disorder (PTSD) is a psychiatric condition triggered by exposure to death, threatened death, or serious injury, whether experienced personally or witnessed. PTSD from childbirth involves situations where a woman feels her life or her infant’s life are at risk. A more inclusive definition of birth trauma includes any childbirth-related event or interaction that leads to intense distress and negatively affect a woman’s well-being. This review aimed to address the gap in effective treatments for PTSD related to childbirth, a significant issue given that approximately one-third of delivering women in the United States likely experience highly stressful and potentially traumatic childbirth. Currently, there are no established routine treatments to prevent or alleviate PTSD resulting from childbirth. The research involved a systematic review and meta-analysis of clinical trials [both randomized controlled trials (RCTs) and nonrandomized trials] assessing various therapies intended to prevent or treat PTSD associated with childbirth.
Labour Agentry and Subsequent Adverse Mental Health Outcomes: A Follow-Up Study of the ARRIVE Trial
Authors: Canfield DR , Allshouse AA , Smith J , Metz TD , Grobman WA , Silver RM 
Published: February 2025

(BJOG. 2024;131(7):970–976. doi:10.1111/1471-0528.17703)
Over 20% of women experience maternal mental health disorders like postpartum depression, anxiety, and PTSD before and after childbirth. These factors may coexist and play a causative role in pregnancy health concerns and maternal death in both the short and long term. In a report from 2022, it was discovered that mental health disorders were the primary reason for deaths related to pregnancy, making up 22.7% of instances. Furthermore, traumatic birthing experiences and a sense of lack of control during delivery are identified as risk factors for PTSD. The impact of control during labor on future mental health outcomes is not well understood. The Labor Agentry Scale (LAS), a validated scoring tool, can gauge labor agentry which is defined as the perceived control level during childbirth. A decrease in LAS scores signifies a lower level of perceived control. While labor advocacy has been associated with increased patient satisfaction, its impact on postpartum mental well-being is not yet understood.
Labor Induction at 41+0 Gestational Weeks or Expectant Management for the Nulliparous Woman: The Finnish Randomized Controlled Multicenter Trial
Authors: Place K , Rahkonen L , Tekay A , Väyrynen K , Orden M-R , Vääräsmäki M , Uotila J , Tihtonen K , Rinne K , Mäkikallio K , Heinonen S , Kruit H 
Published: February 2025

(Acta Obstet Gynecol Scand. 2024;103:505–511. doi:10.1111/aogs14755)
Post-term deliveries increase risks to both mothers and neonates, increasing further with greater gestational age. Recent studies show that labor induction (IOL) at 41 weeks’ gestation or earlier would decrease complication rates without increasing cesarean deliveries (CD) or other costs associated with delivery. In Finland, current guidelines recommend IOL between 41 weeks and 5 days and 42 weeks and 1 day of gestation for healthy pregnancies. Reasons for this include the negative effects of induced labor and allowing the maximum amount of time for spontaneous labor to occur. This study was designed to assess the most beneficial timing of IOL in nulliparous late-term and post-term gestations with a closed cervix, comparing IOL at 41 weeks and 0 days with expectant management and induction at the recommended gestational age. It was hypothesized that earlier IOL would reduce adverse labor outcomes and decrease CD rates.
Predictive Performance of Shock Index for Postpartum Hemorrhage During Cesarean Delivery
Authors: Mizutani H , Ushida T , Ozeki K , Tano S , Iitani Y , Imai K , Nishiwaki K , Kajiyama H , Kotani T 
Published: February 2025

(Int J Obstet Anesth. 58;2024:103957. https://doi.org/10.1016/j.ijoa.2023.103957)
Postpartum hemorrhage (PPH) is a significant obstetric emergency that accounts for ∼20% of maternal deaths globally. In cesarean deliveries (CD), PPH is often described as blood loss >1000 mL, with reported rates ranging from 4.8% to 30%. High-risk pregnancies, like those with advanced maternal age, assisted reproductive technology, multiple pregnancies, or placenta accreta spectrum disorders, are major contributors to the rising rates of PPH. Although there are risk assessment tools available for PPH, they are not universally proven, and around 60% of cases of PPH happen in women who lack risk factors.
Preeclampsia at Term: Evidence of Disease Heterogeneity Based on the Profile of Circulating Cytokines and Angiogenic Factors
Authors: Chaiworapongsa T , Romero R , Gomez-Lopez N , Suksai M , Gallo DM , Jung E , Berry SM , Awonuga A , Tarca AL , Bryant DR 
Published: February 2025

(Am J Obstet Gynecol. 2024;230:450.e1–450.e18. doi:10.1016/j.ajog.2023.10.002)
Preeclampsia (PEC) is one of the leading causes of perinatal and maternal morbidity and mortality in the world. PEC, characterized by high blood pressure and organ damage in pregnancy, occurs in 3% to 7% of pregnancies, and has been linked to intravascular inflammation and an antiangiogenic state. Recent findings suggest that low performance of angiogenic biomarkers in women with PEC at term might be due to only about half of these women having an abnormal angiogenic profile, unlike 90% to 98% of those with early PEC. Early PEC is marked by severe intravascular inflammation, while the role of inflammation in late PEC is still being explored.
Improving Motor Function in Fetal Surgery for Open Spina Bifida
Authors: David AL 
Published: February 2025

(BJOG. 2024;131:768. doi: 10.1111/1471-0528.17730)
The mini commentary describes progress in fetal surgery for open spina bifida (or myelomeningocele, known as MMC), with a primary emphasis on enhancing motor function results. Prenatal surgery for MMC has been widely embraced as the preferred treatment option following the 2011 Management of Myelomeningocele Study (MOMS) clinical trial, leading to enhanced brain and motor function outcomes compared to postnatal surgery. Nevertheless, numerous children encounter obstacles, including mobility limitations and the requirement for daily urinary catheterization, which impacts their quality of life. Spinal cord tethering often occurs after surgery due to fibrosis and inflammation near the repair site of the MMC, which has prompted researchers to investigate ways to enhance surgical outcomes through neuroprotective and immunomodulatory strategies.
Late-Preterm Corticosteroids Exposure and Neurodevelopmental Outcomes
Authors: Vidaeff AC , Asztalos E 
Published: February 2025

(JAMA. 2024; 331(19):1626–1627. doi:10.1001/jama.2024.2228. Epub 2024 April.)
Recent research has prompted a reevaluation of the recommended gestational age limit for administering antenatal corticosteroids. Traditionally, corticosteroids were recommended up to 34 weeks of gestation to improve outcomes for preterm infants. However, studies over the past decade have investigated extending this limit to 37 weeks, potentially benefiting infants born late preterm (34- to 37 wk).
Effective and Simple Interventions to Improve Outcomes for Preterm Infants Worldwide: The FIGO PremPrep-5 Initiative
Authors: Hall M , Valencia CM , Soma-Pillay P , Luyt K , Jacobsson B , Shennan A ,   FIGO Preterm Birth Committee
Published: February 2025

(Int J Gynecol Obstet. 2024;165:929–935. doi:10.1002/ijgo.15269. Epub 2024 January.)
The 2023 WHO Born Too Soon report details the significant impact of preterm birth on global health, emphasizing its role as the leading cause of neonatal and infant mortality worldwide. Preterm birth is defined as delivery before 37 weeks of gestation, and it affected ∼10% of infants globally in 2020, translating to 13.4 million children born preterm. The consequences of preterm birth extend beyond immediate health risks, such as intraventricular hemorrhage and necrotizing enterocolitis, to long-term complications including cerebral palsy, developmental delays, and chronic lung disease.
Reframing Cerebral Palsy as a Lifelong Physical Disability
Authors: Peterson MD 
Published: February 2025

(N Engl J Med. 2024;391(18):1668–1670. doi:10.1056/NEJMp2403366)
Mark D. Peterson, PhD, promotes a change in perspective regarding cerebral palsy (CP), shifting from viewing it as a childhood condition to recognizing it as a permanent physical disability. This shift mirrors the increasing number of grown-ups with CP, which results from improved pediatric health care and boosted lifespan. Despite this change, medical and research facilities still mainly cater to children, resulting in a need for more support and clinical guidance for adults with CP.
A Retrospective Cohort Study of the Anesthetic Management of Postpartum Tubal Ligation
Authors: Ansari J , Sheikh M , Riley E , Guo N , Traynor A , Carvalho B 
Published: February 2025

(Int J Obstet Anesth. 58;2024:103974. https://doi.org/10.1016/j.ijoa.2023.103974)
Tubal ligation after childbirth is a popular birth control option in the United States. ACOG views postpartum tubal ligation (PPTL) as a time-sensitive procedure that must be done promptly to avoid unintended pregnancies. Recent limitations on abortion may lead to an additional rise in the utilization of PPTL. As a large number of women opt for neuraxial labor analgesia, it is common practice to reactivate a current epidural for PPTL, with failure rates ranging from 8% to 26%. Research, such as the one conducted at Lucille Packard Children’s Hospital, discovered decreased failure rates when surgery is done soon after the epidural is placed. As a result, the organization suggested transitioning to de novo spinal anesthesia (SA) after 24 hours postpartum, citing a 2002 study that demonstrated the effectiveness of de novo SA.
Are We Closer to Determining a Gold Standard for Sensory Block Testing During Labor Epidural Analgesia?
Authors: Munro A , Uppal V 
Published: February 2025

(Can J Anesth. 2024;71(6):720–726. doi:10.1007/s12630-023-02686-x)
The use of an epidural during birth is a decision many women make to adequately reduce their pain. Clinicians use sensory block testing to ensure the anesthesia is appropriately delivered to the body in a manner that will adequately alleviate pain and not inhibit critical processes. Munro and Uppal comment on the recent publication by Casellato and colleagues, to review their protocol and findings while also reviewing the field generally.
An Innovative Approach to Determine Programmed Intermittent Epidural Bolus Pump Settings for Labor Analgesia: A Randomized Controlled Trial
Authors: Munro A , George RB , Andreou P 
Published: February 2025

(Anesth Analg. 2024;139(3):545–554. doi:10.1213/ANE.0000000000006813)
Programmed intermittent epidural bolus (PIEB) analgesia has many benefits in the labor and delivery setting. This article had the goal of using response surface methodology (RSM) to determine optimal PIEB settings while also evaluating maternal satisfaction, clinician-administered manual bolus requirements, and the delivered amount of patient-controlled epidural analgesia (PCEA) doses.
Brief Assessment of Patient Phenotype to Explain Variability in Postsurgical Pain and Opioid Consumption After Cesarean Delivery: Performance of a Novel Brief Questionnaire Compared To Long Questionnaires
Authors: He J , Wilson JM , Fields KG , Zachos KMF , Franqueiro AR , Reale SC , Farber MK , Bateman BT , Edwards RR , Rathmell JP , Soens M , Schreiber KL 
Published: February 2025

(Anesthesiology. 2024;140:701–714. doi:10.1097/ALN.0000000000004900)
Moderate or severe postsurgical pain is reported by a high number of patients following cesarean delivery (CD). Globally, it is the most common surgery performed, and higher pain levels after surgery are associated with persistent postsurgical pain and chronic opioid use. In addition, pain that is present before surgery is associated with worse postoperative pain and thus greater consumption of medications to manage pain. Current tools used to assess psychosocial factors associated with use of pain medication and postoperative pain levels include mainly dichotomous measures or extremely long comprehensive assessments. This study was designed to compare 3 sets of questionnaires that differ in length and detail to explain postoperative pain and opioid consumption variability after CD; first, a 3-item questionnaire (3-IQ); second, a 58-item long questionnaire with the 3-IQ; and third, a novel 19-item brief questionnaire in addition to the 3-IQ.
Long-Term Clarity of Tectonic Lamellar Keratoplasty for Limbal Dermoids
Authors: Tomioka Yasufumi , Bato Kotomi , Suzuki Tomo , Wakimasu Koichi , Fukuoka Hideki , Okumura Naoki , Inatomi Tsutomu , Sotozono Chie , Kinoshita Shigeru 
Published: February 2025

Purpose:
To investigate the long-term outcome of surgical intervention for limbal dermoids and to evaluate the safety and efficacy of tectonic lamellar keratoplasty.

Methods:
This retrospective cohort study included 86 eyes that underwent tectonic lamellar keratoplasty by 5 corneal surgeons at Kyoto Prefectural University of Medicine and Baptist Eye Institute, Kyoto, Japan, from 1992 through 2024. The study subjects were categorized into 2 groups: group A, consisting of 35 eyes that underwent amblyopia treatment, and group B, consisting of 51 eyes that did not.

Results:
Kaplan–Meier survival analysis revealed 95.3% (82 of 86 eyes) maintained clear tectonic corneal grafts with healthy ocular surfaces postoperatively. Three eyes developed psudopterygium formation, and 1 eye developed a corneal infection. Improvement of 0.2 logarithm of the minimum angle of resolution units or more because of preoperative amblyopia treatment was observed in 48.6% (17 of 35 eyes) in group A. Surgical intervention resulted in an improvement of 0.2 logarithm of the minimum angle of resolution units or more in 25.7% (9 of 35 eyes) in group A, and 15.7% (8 of 51 eyes) in group B. One case of corneal infection resulted in decreased best-corrected visual acuity. No other cases exhibited best-corrected visual acuity deterioration.

Conclusions:
Tectonic lamellar keratoplasty can be performed safely with very few postoperative complications, maintaining long-term corneal clarity, reasonable visual acuity, and satisfactory cosmetic results.
Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters
Authors: Floyd Brendan M. , Schmidt Elizabeth L. , Till Nicholas A. , Yang Jonathan L. , Liao Pinyu , George Benson M. , Flynn Ryan A. , Bertozzi Carolyn R. 
Published: February 2025

AbstractThe cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven by aberrant cell surface phenotypes. The spatial organization of cell surface proteins is central to these processes. High-resolution fluorescence microscopy and proximity labeling have advanced studies of surface protein associations, but the spatial organization of the complete surface proteome remains uncharted. In this study, we systematically mapped the surface proteome of human T-lymphocytes and B-lymphoblasts using proximity labeling of 85 antigens, identified from over 100 antibodies tested for binding to surface-exposed proteins. These experiments were coupled with an optimized data-independent acquisition mass spectrometry workflow to generate a robust dataset. Unsupervised clustering of the resulting interactome revealed functional modules, including well-characterized complexes such as the T-cell receptor and HLA class I/II, alongside novel clusters. Notably, we identified mitochondrial proteins localized to the surface, including the transcription factor TFAM, suggesting previously unappreciated roles for mitochondrial proteins at the plasma membrane. A high-accuracy machine learning classifier predicted over 6,000 surface protein associations, highlighting functional associations such as IL10RB’s role as a negative regulator of type I interferon signaling. Spatial modeling of the surface proteome provided insights into protein dispersion patterns, distinguishing widely distributed proteins, such as CD45, from localized antigens, such as CD226 pointing to active mechanisms of regulating surface organization. This work provides a comprehensive map of the human surfaceome and a resource for exploring the spatial and functional dynamics of the cell membrane proteome.
Selective State Space Models Outperform Transformers at Predicting RNA-Seq Read Coverage
Authors: Holmes Ian , Linder Johannes , Kelley David 
Published: February 2025

AbstractTransformers are the basis for many state-of-the-art machine learning tools, including those for predicting gene expression data from DNA sequence. The considerable time and cost of training transformer models has motivated development of alternative approaches inspired by ideas from the signal-processing literature, such as state-space models (Mamba), Fourier transforms (Hyena), and wavelet transforms (MultiResNet). To evaluate these methods as potential replacements (or complements) for attention, we developed a software library bilby, implemented using Python and Jax/Flax, providing convolutional, attention, bidirectional Hyena, bidirectional Mamba, and striped-architecture models for supervised multi-task learning in functional genomics. We report a comparison of these architectures, testing several hyperparameters and variations, and reporting performance statistics for the withheld test set as well as downstream SNP classifiers. Relative to models comprising convolution and attention layers (implemented in Python and TensorFlow via the Baskerville library used by the Borzoi software), models comprising convolutional, bidirectional Mamba, and (optionally) attention layers achieve small but consistent improvements in prediction accuracy, for roughly comparable training times and parameter counts, when averaged across all output tracks and data splits (a proportional increase of 3-4% in Pearson R, and 1-2% in r2, with the highest gains achieved when Mamba and attention layers were combined in a striped architecture). In contrast, Hyena (when reimplemented as described in the literature) was not competitive with attention-based models at these tasks, while MultiResNet proved too slow to be practical. The gains in prediction accuracy of the Mamba-based models do not yet translate to significantly improved performance on downstream SNP classification tasks: benchmarks using a GTEx eQTL dataset yield roughly similar results for Mamba- and attention-based classifiers, with attention marginally outperforming Mamba in one metric (a difference of +0.007 in area under ROC) and slightly underperforming by another metric (a difference of −0.006 in Spearman rank correlation). We argue that these results suggest selective state-space models (such as Mamba and Striped Mamba) warrant further exploration for functional genomics tasks. Our code and trained models are publicly available athttps://github.com/ihh/bilby.
The molecular basis for DNA-binding by competence T4P is distinct in Gram-positive and Gram-negative species
Authors: Christman Nicholas D. , Dalia Ankur B. 
Published: February 2025

ABSTRACTCompetence type IV pili (T4P) are bacterial surface appendages that facilitate DNA uptake during horizontal gene transfer by natural transformation. These dynamic structures actively extend from the cell surface, bind to DNA in the environment, and then retract to import bound DNA into the cell. Competence T4P are found in diverse Gram-negative (diderm) and Gram-positive (monoderm) bacterial species. While the mechanism of DNA-binding by diderm competence T4P has been the recent focus of intensive study, relatively little is known about DNA-binding by monoderm competence T4P. Here, we useStreptococcus pneumoniaeas a model system to address this question. Competence T4P likely bind to DNA via a tip-associated complex of proteins called minor pilins, and recent work highlights a high degree of structural conservation between the minor pilin tip complexes of monoderm and diderm competence T4P. In diderms, positively charged residues in one minor pilin, FimT, are critical for DNA-binding. We show that while these residues are conserved in ComGD, the FimT homolog of monoderms, they only play a minor role in DNA uptake for natural transformation. Instead, we find that two-positively charged residues in the neighboring minor pilin, ComGF (the PilW homolog of monoderms), play the dominant role in DNA uptake for natural transformation. Furthermore, we find that these residues are conserved in other monoderms, but not diderms. Together, these results suggest that the molecular basis for DNA-binding has either diverged or evolved independently in monoderm and diderm competence T4P.AUTHOR SUMMARYDiverse bacteria use extracellular structures called competence type IV pili (T4P) to take up DNA from their environment. The uptake of DNA by T4P is the first step of natural transformation, a mode of horizontal gene transfer that contributes to the spread of antibiotic resistance and virulence traits in diverse clinically relevant Gram-negative (diderm) and Gram-positive (monoderm) bacterial species. While the mechanism of DNA binding by competence T4P in diderms has been an area of recent study, relatively little is known about how monoderm competence T4P bind DNA. Here, we explore how monoderm competence T4P bind DNA usingStreptococcus pneumoniaeas a model system. Our results indicate that while monoderm T4P and diderm T4P likely have conserved structural features, the DNA-binding mechanism of each system is distinct.
Theoretical framework for enhancing or enabling cooling of a mechanical resonator via the anti-Stokes or Stokes interaction and zero-photon detection
Authors: Clarke Jack , Cryer-Jenkins Evan A. , Gupta Arjun , Major Kyle D. , Zhang Jinglei , Enzian Georg , Szczykulska Magdalena , Leung Anthony C. , Rathee Harsh , Svela Andreas Ø. , Tan Anthony K. C. , Beige Almut , Mølmer Klaus , Vanner Michael R. 
Published: February 2025

We develop a theoretical framework to describe how zero-photon detection may be utilized to enhance optomechanical laser cooling via the anti-Stokes interaction and, somewhat surprisingly, enable cooling via the Stokes interaction commonly associated with heating. Our description includes both pulsed and continuous measurements as well as optical detection efficiency and open-system dynamics. For both cases, we discuss how the cooling depends on the system parameters such as detection efficiency and optomechanical cooperativity, and we study the continuous-measurement-induced dynamics, contrasting with single-photon-detection events. For the Stokes case, we explore the interplay between cooling and heating via optomechanical parametric amplification, and we find the minimum efficiency required to cool a mechanical oscillator via zero-photon detection. This work serves as a companion article to our recent experiment [E. A. Cryer-Jenkins , ], which demonstrated enhanced laser cooling of a mechanical oscillator via zero-photon detection on the anti-Stokes signal. The cooling techniques developed here can be applied to a wide range of areas including nonclassical state preparation, quantum thermodynamics, and avoiding the often unwanted heating effects of parametric amplification.

Published by the American Physical Society
2025