bluuebunny/crossref_metadata_2025_split huggingface dataset:
General rules for clinical and pathological studies on oral cancer (2nd edition): a synopsis
Authors:   Scientific Committee on General Rules for Clinical and Pathological Studies of Oral Cancer, Japanese Society of Oral Oncology, Ota Yoshihide , Noguchi Tadahide , Ariji Eiichiro , Fushimi Chihiro , Fuwa Nobukazu , Harada Hiroyuki , Hayashi Takafumi , Hayashi Ryuichi , Honma Yoshitaka , Miura Masahiko , Mori Taisuke , Nagatsuka Hitoshi , Okura Masaya , Ueda Michihiro , Uzawa Narikazu , Yagihara Kazuhiro , Yagishita Hisao , Yamashiro Masashi , Yanamoto Souichi , Kirita Tadaaki 
Published: March 2021

AbstractFor doctors and other medical staff treating oral cancer, it is necessary to standardize the basic concepts and rules for oral cancer to achieve progress in its treatment, research, and diagnosis. Oral cancer is an integral part of head and neck cancer and is treated in accordance with the general rules for head and neck cancer. However, detailed rules based on the specific characteristics of oral cancer are essential. The objective of this article was to contribute to the development of the diagnosis, treatment, and research of oral cancer, based on the correct and useful medical information of clinical, surgical, pathological, and imaging findings accumulated from individual patients at various institutions. Our general rules were revised as the UICC was revised for the 8th edition and were published as the Japanese second edition in 2019. In this paper, the English edition of the “Rules” section is primarily presented.
Trade in Carbon and Carbon Tariffs
Authors: Böhringer Christoph , Schneider Jan , Asane-Otoo Emmanuel 
Published: March 2021

AbstractCarbon-based import tariffs are proposed as a policy measure to reduce carbon leakage and increase the global cost-effectiveness of unilateral CO2emission pricing. We investigate the case for carbon tariffs. For our assessment, we combine multi-region input–output and computable general equilibrium analyses based on data from the World Input–Output Database for the period 2000–2014. The multi-region input–output analysis confirms that carbon embodied in trade has increased during this period, but trade flows from Non-OECD to OECD countries became less important in relative terms since the 2007–2008 financial crisis. The computable general equilibrium analysis suggests that carbon tariffs’ efficacy in combating leakage increases in periods when trade in carbon increases. However, its potential to improve the global-cost effectiveness of unilateral emission pricing remains modest. On the other hand, we find that the potential of carbon tariffs to shift the economic burden of CO2emission reduction from abating developed regions to non-abating developing regions increases sharply between 2000 and 2007, but declines after the financial crisis.
Did Cyclic Metaphosphates Have a Role in the Origin of Life?
Authors: Glonek Thomas 
Published: March 2021

AbstractHow life began still eludes science life, the initial progenote in the context presented herein, being a chemical aggregate of primordial inorganic and organic molecules capable of self-replication and evolution into ever increasingly complex forms and functions.Presented is a hypothesis that a mineral scaffold generated by geological processes and containing polymerized phosphate units was present in primordial seas that provided the initiating factor responsible for the sequestration and organization of primordial life’s constituents. Unlike previous hypotheses proposing phosphates as the essential initiating factor, the key phosphate described here is not a polynucleotide or just any condensed phosphate but a large (in the range of at least 1 kilo-phosphate subunits), water soluble, cyclic metaphosphate, which is a closed loop chain of polymerized inorganic phosphate residues containing only phosphate middle groups. The chain forms an intrinsic 4-phosphate helix analogous to its structure in Na Kurrol’s salt, and as with DNA, very large metaphosphates may fold into hairpin structures. Using a Holliday-junction-like scrambling mechanism, also analogous to DNA, rings may be manipulated (increased, decreased, exchanged) easily with little to no need for additional energy, the reaction being essentially an isomerization.A literature review is presented describing findings that support the above hypothesis. Reviewed is condensed phosphate inorganic chemistry including its geological origins, biological occurrence, enzymes and their genetics through eukaryotes, polyphosphate functions, circular polynucleotides and the role of the Holliday junction, previous biogenesis hypotheses, and an Eoarchean Era timeline.
A Parametrizable High-Level Synthesis Library for Accelerating Neural Networks on FPGAs
Authors: Kalms Lester , Rad Pedram Amini , Ali Muhammad , Iskander Arsany , Göhringer Diana 
Published: March 2021

AbstractIn recent years, Convolutional Neural Network CNN have been incorporated in a large number of applications, including multimedia retrieval and image classification. However, CNN based algorithms are computationally and resource intensive and therefore difficult to be used in embedded systems. FPGA based accelerators are becoming more and more popular in research and industry due to their flexibility and energy efficiency. However, the available resources and the size of the on-chip memory can limit the performance of the FPGA accelerator for CNN. This work proposes an High-Level Synthesis HLS library for CNN algorithms. It contains seven different streaming-capable CNN (plus two conversion) functions for creating large neural networks with deep pipelines. The different functions have many parameter settings (e.g. for resolution, feature maps, data types, kernel size, parallelilization, accuracy, etc.), which also enable compile-time optimizations. Our functions are integrated into the HiFlipVX library, which is an open source HLS FPGA library for image processing and object detection. This offers the possibility to implement different types of computer vision applications with one library. Due to the various configuration and parallelization possibilities of the library functions, it is possible to implement a high-performance, scalable and resource-efficient system, as our evaluation of the MobileNets algorithm shows.
Investigation on the potential of poplar bark from short-rotation coppices as bio-based fungicidal additives
Authors: Bremer Martina , Oktaee Javane , Einer Daniela , Fischer Steffen , Wagenführ André 
Published: March 2021

AbstractBark on trees protects the plant against environmentally adverse conditions as well as fungi and insect attacks. There are different chemical substances, mostly in the outer bark of trees, which can stop fungi from developing. Bark as a by-product of wood plantations is available in high quantity and can serve as an excellent source for the production of eco-fungicides. In the presented article, bark of various poplar clones from two short-rotation coppices (SRC) in Poland and Germany was examined to determine the chemical composition, the possible extraction of potential fungicides (terpenes, aromatic and phenolic substances), and influence of their extracts on slowing the growth of mold fungi. It was proved that the content of the fungicidal substances depends strongly on the clone type. Two methods of extraction—Soxhlet and batch—were compared to obtain fungicidal extracts. Fungicidal substances were found in extracts gained with both approaches. Triterpenes, fatty acids, aldehydes, and alcohols were primarily the active fungicides in the Soxhlet extracts, whereas phenolic substances act as fungicides in the batch extracts.
Strengthening the Innovation Resilience of Polish Manufacturing Firms in Unstable Environments
Authors: Wziątek-Kubiak Anna , Pęczkowski Marek 
Published: March 2021

AbstractThis study examines factors that increase resilience in innovation of Polish manufacturing firms in an unstable environment. Organizational resilience in innovation is the ability to continuously perform innovation in a turbulent environment and increase knowledge accumulation. In 2008–2012, Poland did not have crisis itself. Short-term slowdown of the economy was accompanied by a breakdown of innovation activities, with a medium-term effect. Based on the Polish Community Innovation Survey panel data for two periods: the innovation crisis (2008–2010), and the innovation pessimism period (2010–2012), this study shows which innovative resources change the probability of innovation continuity in the second period. In our probit model, we explore 42 factors of innovations. We found that financing, R&D and marketing increased the probability of continuity of innovation, but the influence of financing was the strongest. Persistence in innovation in turbulent times hence requires a change in the structure of innovation resources used. Due to the fact that public support on innovation did not increase the likelihood of the continuity of the innovation, a policy change is required. Reliability of our estimation is confirmed by accuracy of prediction of firms, which was 78.2%.
Toward Reverse Engineering to Economic Analysis: An Overview of Tools and Methodology
Authors: Faggini Marisa , Bruno Bruna , Parziale Anna 
Published: March 2021

AbstractFollowing the reverse engineering (RE) approach to analyse an economic complex system is to infer how its underlying mechanism works. The main factors that condition the difficulty of RE are the number of variable components in the system and, most importantly, the interdependence of components on one another and nonlinear dynamics. All those aspects characterize the economic complex systems within which economic agents make their choices. Economic complex systems are adopted in RE science, and they could be used to understand, predict and model the dynamics of the complex systems that enable to define and to control the economic environment. With the RE approach, economic data could be used to peek into the internal workings of the economic complex system, providing information about its underling nonlinear dynamics. The idea of this paper arises from the aim to deepen the comprehension of this approach and to highlight the potential implementation of tools and methodologies based on it to treat economic complex systems. An overview of the literature about the RE is presented, by focusing on the definition and on the state of the art of the research, and then we consider two potential tools that could translate the methodological issues of RE by evidencing advantages and disadvantages for economic analysis: the recurrence analysis and the agent-based model (ABM).
Heavy metals concentration and pollution index (HPI) in drinking water along the southwest coast of Ghana
Authors: Appiah-Opong Regina , Ofori Amoako , Ofosuhene Mark , Ofori-Attah Ebenezer , Nunoo Francis K. E. , Tuffour Isaac , Gordon Christopher , Arhinful Daniel K. , Nyarko Alexander K. , Fosu-Mensah Benedicta Y. 
Published: March 2021

AbstractThe concentration of seven heavy metals in water samples was analyzed along the southwest coast of Ghana in the wet and dry seasons using atomic absorption spectrophotometer. Some physicochemical properties of the water samples were also determined to assess the quality of the water. The ranges of metal concentration in water in the wet season were; As (1.23–7.84 µg/L), Cu (4.10–24.09 µg/L), Pb (4.08–57.98 µg/L), Se (BDL-0.38 µg/L), Zn (2.86–17.75 µg/L) and Hg (0.023–0.068 µg/L), whereas the ranges of metal concentration in the dry season were; As (2.30–5.78 µg/L), Pb (25.47–70.73 µg/L), Se (0.081–0.158 µg/L), Zn (0.79–22.80 µg/L) and Hg (0.004–0.047 µg/L). The results of physicochemical properties of water in the wet season were pH (6.83 to 7.52), EC (291.15–780.64 µS/cm), TDS (195.07–523.02 mg/L), DO (2.98–4.39 mg/L), BOD (3.33 to 6.84 mg/L), salinity (0.01 to 0.30 ppt) and temperature (27.06–30.94 °C), whereas the dry season recorded the ranges of pH (6.84–6.95), EC (516.83 to 660.67 µS/cm), TDS (307.07–442.65 mg/L), DO (1.71–3.04 mg/L), BOD (4.25–13.38 mg/L), salinity (0.22–0.28ppt) and temperature (28.46–30.44 °C). The results showed that the concentration of heavy metals in water was below the WHO standard except Pb which exceeded the limit. The mean heavy metal pollution index (HPI) were 130 and 143 for wet and dry seasons, respectively, indicating that the water HPI was above the critical limit (HPI > 100), hence unfit for drinking. All the physicochemical properties analyzed were within the WHO permissible limits except BOD.
Reflecting on the Anthropocene: The Call for Deeper Transformations
Authors: O’Brien Karen 
Published: March 2021

AbstractResearch on global environmental change has transformed the way that we think about human-environment relationships and Earth system processes. The four Ambio articles highlighted in this 50th Anniversary Issue have influenced the cultural narrative on environmental change, highlighting concepts such as “resilience,” “coupled human and natural systems”, and the “Anthropocene.” In this peer response, I argue that global change research is still paying insufficient attention to how to deliberately transform systems and cultures to avoid the risks that science itself has warned us about. In particular, global change research has failed to adequately integrate the subjective realm of meaning making into both understanding and action. Although this has been an implicit subtext in global change research, it is time to fully integrate research from the social sciences and environmental humanities.
You are what you eat: relative importance of diet, gut microbiota and nestmates for honey bee, Apis mellifera, worker health
Authors: Retschnig Gina , Rich Johannes , Crailsheim Karl , Pfister Judith , Perreten Vincent , Neumann Peter 
Published: March 2021

AbstractIn eusocial honey bees, Apis mellifera, diet, gut microbiota and nestmates can all contribute to the health of freshly emerged individual workers, but their relative importance for longevity and body weight is currently unknown. Here, we show that diet is most relevant, followed by gut microbiota and the presence of nestmates. Freshly emerged workers were randomly assigned to eight treatments (with or without honey/pollen, protein-substitute lactalbumin, antibiotic tetracycline and nestmates for 24 h) and maintained under standardised laboratory conditions. Longevity and food consumption were measured daily and fresh body weight was assessed at day 7. The data show a significantly better survival and a higher body weight in workers supplied with honey/pollen. Survival was higher in the lactalbumin treatments compared to the ones restricted to sucrose only, but lower compared to those with honey/pollen, highlighting the importance of micronutrients. In contrast, antibiotic treatment had a significant negative effect on longevity and body weight, which may be explained by inactivated gut microbiota and/or toxicity of the antibiotics. There was no positive effect of nestmates, probably due to the short exposure period. In contrast, nestmates showed a negative effect on survival in antibiotic-treated workers, possibly by transmitting pathogens and antibiotic-induced gut dysbiosis. In conclusion, a macro- and micronutrient-rich diet appears to be the key to individual honey bee worker health. Providing an optimal diet and possibly gut microbiota appears to be a promising way to promote managed A. mellifera health.
Querying Optimal Routes for Group Meetup
Authors: Chen Bo , Zhu Huaijie , Liu Wei , Yin Jian , Lee Wang-Chien , Xu Jianliang 
Published: March 2021

AbstractMotivated by location-based social networks which allow people to access location-based services as a group, we study a novel variant of optimal sequenced route (OSR) queries, optimal sequenced route for group meetup (OSR-G) queries. OSR-G query aims to find the optimal meeting POI (point of interest) such that the maximum users’ route distance to the meeting POI is minimized after each user visits a number of POIs of specific categories (e.g., gas stations, restaurants, and shopping malls) in a particular order. To process OSR-G queries, we first propose an OSR-Based (OSRB) algorithm as our baseline, which examines every POI in the meeting category and utilizes existing OSR (called E-OSR) algorithm to compute the optimal route for each user to the meeting POI. To address the shortcomings (i.e., requiring to examine every POI in the meeting category) of OSRB, we propose an upper bound based filtering algorithm, called circle filtering (CF) algorithm, which exploits the circle property to filter the unpromising meeting POIs. In addition, we propose a lower bound based pruning (LBP) algorithm, namely LBP-SP which exploits a shortest path lower bound to prune the unqualified meeting POIs to reduce the search space. Furthermore, we develop an approximate algorithm, namely APS, to accelerate OSR-G queries with a good approximation ratio. Finally the experimental results show that both CF and LBP-SP outperform the OSRB algorithm and have high pruning rates. Moreover, the proposed approximate algorithm runs faster than the exact OSR-G algorithms and has a good approximation ratio.
Discrimination of ablation, shielding, and interface layer effects on the steady-state formation of persistent bubbles under liquid flow conditions during laser synthesis of colloids
Authors: Kalus Mark-Robert , Lanyumba Riskyanti , Barcikowski Stephan , Gökce Bilal 
Published: March 2021

AbstractOver the past decade, laser ablation in liquids (LAL) was established as an innovative nanoparticle synthesis method obeying the principles of green chemistry. While one of the main advantages of this method is the absence of stabilizers leading to nanoparticles with “clean” ligand-free surfaces, its main disadvantage is the comparably low nanoparticle production efficiency dampening the sustainability of the method and preventing the use of laser-synthesized nanoparticles in applications that require high amounts of material. In this study, the effects of productivity-dampening entities that become particularly relevant for LAL with high repetition rate lasers, i.e., persistent bubbles or colloidal nanoparticles (NPs), on the synthesis of colloidal gold nanoparticles in different solvents are studied. Especially under batch ablation conditions in highly viscous liquids with prolonged ablation times both shielding entities are closely interconnected and need to be disentangled. By performing liquid flow-assisted nanosecond laser ablation of gold in liquids with different viscosity and nanoparticle or bubble diffusivity, it is shown that a steady-state is reached after a few seconds with fixed individual contributions of bubble- and colloid-induced shielding effects. By analyzing dimensionless numbers (i.e., Axial Peclet, Reynolds, and Schmidt) it is demonstrated how these shielding effects strongly depend on the liquid’s transport properties and the flow-induced formation of an interface layer along the target surface. In highly viscous liquids, the transport of NPs and persistent bubbles within this interface layer is strongly diffusion-controlled. This diffusion-limitation not only affects the agglomeration of the NPs but also leads to high local densities of NPs and bubbles near the target surface, shielding up to 80% of the laser power. Hence, the ablation rate does not only depend on the total amount of shielding matter in the flow channel, but also on the location of the persistent bubbles and NPs. By comparing LAL in different liquids, it is demonstrated that 30 times more gas is produced per ablated amount of substance in acetone and ethylene glycol compared to ablation in water. This finding confirms that chemical effects contribute to the liquid’s decomposition and the ablation yield as well. Furthermore, it is shown that the highest ablation efficiencies and monodisperse qualities are achieved in liquids with the lowest viscosities and gas formation rates at the highest volumetric flow rates.
Myopericarditis Associated With Smallpox Vaccination Among US Army Personnel – Fort Hood, Texas, 2018
Authors: Mandra Anna M. , Superior Michael J. , Guagliardo Sarah Anne J. , Hesse Elisabeth , Pacha Laura A. , Stidham Ralph A. , Colbeck Debra C. , Hrncir David E. , Hall Noemi , Petersen Brett W. , Rao Agam K. 
Published: March 2021

AbstractObjective:In March 2018, the US Department of Defense (DOD) added the smallpox vaccination, using ACAM2000, to its routine immunizations, increasing the number of persons receiving the vaccine. The following month, Fort Hood reported a cluster of 5 myopericarditis cases. The Centers for Disease Control and Prevention and the DOD launched an investigation.Methods:The investigation consisted of a review of medical records, establishment of case definitions, causality assessment, patient interviews, and active surveillance. A 2-sided exact rate ratio test was used to compare myopericarditis incidence rates.Results:This investigation identified 4 cases of probable myopericarditis and 1 case of suspected myopericarditis. No alternative etiology was identified as a cause. No additional cases were identified. There was no statistically significant difference in incidence rates between the observed cluster (5.23 per 1000 vaccinated individuals, 95% CI: 1.7–12.2) and the ACAM2000 clinical trial outcomes for symptomatic persons, which was 2.29 per 1000 vaccinated individuals (95% CI: 0.3–8.3).Conclusions:Vaccination with ACAM2000 is the presumptive cause of this cluster. Caution should be exercised before considering vaccination campaigns for smallpox given the clinical morbidity and costs incurred by a case of myopericarditis. Risk of myopericarditis should be carefully weighed with risk of exposure to smallpox.
Conceptual Problems of the Right to Breathe Clean Air
Authors: Jankovic Sava 
Published: March 2021

AbstractThis Article undertakes the conceptual analysis of the right to breathe clean air, concentrating predominantly on the perplexities of this highly important environmental right. In its first part, this Article brings forward a few aspects illustrating general ambiguity and imprecision of the right. As will be shown, it is quite troublesome to firmly indicate which foundations (legal v. moral) or character (individual v. collective) the right to breathe clean air has, as well as to which category (generations of human rights) it belongs to. Similarly, its temporal determination (present-day v. future) is uncertain, and it is easy to confuse or conflate the substantive right with procedural rights. In the second part, this Article identifies and describes more serious and specific difficulties surrounding the right, which negatively influence conceiving the right to breathe clean air as a legal right. In the beginning, the reference is made to its nonautonomous character. Subsequently, this Article explores the issues of the content of the right, outlining problems with the meaning, the indeterminacy of the subjects of the said right, and its absence at the international level. Finally, this Article highlights hurdles concerning the enforceability of the right. This Article concludes that, at present, it is troublesome to conceptualize the right to breathe clean air as hard law, however, the situation may change in the future.