bluuebunny/crossref_metadata_2025_split huggingface dataset:
ADCY2, ADCY5, and GRIA1 are the key genes of cAMP signaling pathway to participate in osteoporotic spinal fracture after the manipulation of Wnt signaling
Authors: Zuo Xiaohua , Zhou Changdong , Zhu Xuepiao , Liu Dan , Wang Yan , Bao Hongguang , Zhang Kai , Zhang Yong 
Published: April 2021

IntroductionOsteoporotic spinal fracture, characterized by high morbidity and mortality, has become a health burden for the aging population. The inactivation of the Wnt signaling has been proved to promote osteoporotic fractures. Our study is to identify the key genes, miRNAs, and pathways that possibly lead to osteoporosis and osteoporotic spinal fracture after the aberrant activation or mutation of Wnt signaling pathway.Material and methodsImpute R package was used to screen out the differently expressed genes (DEGs) and differently expressed miRNAs in GEO datasets. STRING and Metascape were used to construct protein-protein interactions (PPI) network, gene ontology (GO) enrichment and pathway enrichment. The relative expression of ADCY2, ADCY5, and GRIA1 in bone tissues was measured by RT-qPCR.Results562 DEGs were screened out using Impute R package, and a PPI network involving the 562 DEGs was constructed using STRING and Metascape. GO enrichment and pathway enrichment showed that the 562 DEGs were associated with membrane protein-related signaling pathways. Then, 75 genes between the target genes of miR-18a-3p and 562 DEGs were overlapped using Venny 2.1.0. Finally, the cAMP signaling pathway was identified as the key pathway, whilst ADCY2, ADCY5, and GRIA1 were identified the key genes that possibly participate in osteoporotic spinal fracture after the manipulation of Wnt signaling pathway, which was further proved by their excessive downregulation in osteoporotic patients with spinal fracture.ConclusionsThe results demonstrated that ADCY2, ADCY5, and GRIA1 were the key genes to regulate the cAMP signaling pathway in osteoporotic spinal fracture after abnormal Wnt signaling.
Robust Food Supply Chain Traceability System based on HACCP using Federated Blockchain
Authors: Danish Muhammad , Hasan Muhammad Shahwaiz 
Published: April 2021

In this fast growing world, everything needs to change and upgrade with the technology to survive in this rapidly changing environment. The Food Supply Chain system is one of them. In traditional supply chain management functions, it is hard to manage the flow of traceability information of products timely and effectively among upstream to downstream stakeholders.This gap in the flow of information and untrusted traceability of product causes to generate food contamination hazards and also increasing the network of modern FSC systems is still challenging to provide quality, privacy, and integrity of traceability mechanism. HACCP and Blockchain-based FSC provide various functions to enhance the FSC process such as traceability,transparency, security among all stakeholders. In these functions, some most important functions of the Food Supply Chain system are traceability, amount of data sharing, and privacy of data of products among stakeholders.
In this paper, we are going to provide an Enhanced Food Supply Chain Traceability system based on Federated Blockchain with HACCP using smart contracts. This model will manage by pre- selected leaders’ nodes. These leaders’ nodes have the right to control the action of middle nodes and lower nodes. The amount of data sharing can also be controlled by the leaders’ nodes.So, any particular transaction is restricted to perform by middle and lower nodes because the Federated Blockchain is partially decentralized. This model overcomes the issue of privacy concern which remains unsolved by blockchain-based FSC and makes a better and enhanced Federated Blockchain-based FSC traceability system.
ADULT PRESENTATION OF HIRSCHSPRUNG’S DISEASE; A CASE REPORT
Authors: Malik Zainab , Gul Salma , Khaliq Bhinder Khurram 
Published: April 2021

Abstract
Young patients presenting with chronic constipation and failure to thrive, should be promptly investigated and looked upon for late presentation of congenital diseases like Hirschsprung disease (HD). This case is reported to highlight rare case of adult presentation of HD who presented to emergency department with complaints of lower abdominal pain, flatulence and lethargy. Considering the findings of CT scan suspicion of Adult presentation of HD was given and lateral biopsy confirmed the diagnosis.
Experimental studies of the capillary desaturation curve in polymer-surfactant flooding
Authors: Skripkin A. G. , Koltsov I. N. , Milchakov S. V. 
Published: April 2021

The paper presents the results of laboratory studies of polymer-surfactant flooding on core samples of different permeability. The obtained data are used in hydrodynamic modeling.
Experimental studies included:
• study of the dynamics of oil displacement, plotting the dependence of the residual oil saturation on the surfactant concentration – interfacial tension at the interface of the surfactant-oil solution;
• comparative experimental studies of residual oil saturation when oil is displaced by surfactant compositions of various manufacturers;
• comparative studies of phase permeability in flood experiments for the filtration of oil and water, oil and polymer-surfactant solution at different ratios in the flow.
The effect of dry demineralized whey (DDW) and coconut oil on the rheological characteristics of the legume butter
Authors: Stadnyk Igor , Piddubnyi Volodymyr , Kravchenko Mykhail , Rybchuk Larysa , Balaban Stepan , Veselovska Taisia 
Published: April 2021

This article reveals the possibility of using legume butter to obtain a new combined product of increased quality. The technology of model compositions of finishing semi-finished products, in particular, confectionery legume butter with DDW, has been developed. The results of a study on optimizing the recipe composition of finishing semi-finished products made it possible to develop this technology of multifunctional confectionery butter with the desired (specified) organoleptic and structural and mechanical properties. The analysis of the formation of the structure of legume butter of oppositely directed processes in the enzymatic destruction of the residual cellular structure and spontaneous aggregation of protein particles into the spatial structure due to gradual dehydration of the system was carried out. It is noted that sugar plays the role of a plasticizer, reducing the rate of gelatinization of starch while reducing the viscosity peak. The use of dry demineralized whey (DDW) in legume butter technologies contributes to the formation of a stronger structure of the protein component and the development of a spatial structure, which gives it certain structural and mechanical properties. Three main directions of technological use of confectionery butter were established, which are based on structural characteristics of consistency: 1 – confectionery butter used to cover confectionery products and as a layer for them (CP – Confectionery Products), where the main indicator of consistency is extensibility; 2 – confectionery butter used for making flowers, as a decorative element for flour confectionery (SC – Sugar Confectionery)), where the main indicator of consistency is an equivalent ratio of extensibility and forming ability; 3 – confectionery butter used for modeling shaped products, as a decorative element for flour confectionery products, where the main indicator of consistency is the forming ability. The results of studies of the rheological characteristics of legume butter with dry demineralized whey (DDW) and coconut oil are presented. It was ascertained that DDW and coconut oil lead to changes in the state of legume butter, changing the values of rheological characteristics. The rational content of DDW and coconut oil in the composition of legume butter while ensuring high functional and technological properties was proved. The optimal ratios of components of the developed legume butter were mathematically grounded.
The diversity of fungal population from grape harvest to young wine in Small Carpathian wine region
Authors: Felšöciová Soňa , Sabo Jozef , Galovičová Lucia , Kačániová Miroslava 
Published: April 2021

The study aimed to identify the filamentous fungi and yeast mycobiota found on the surface and in grapes, grape must, and wine obtained from four red grape varieties: Alibernet, Dornfelder, Blue Frankish, Cabernet Sauvignon, and four white grape varieties: Green Veltliner, Rheinriesling, Pinot Blanc, Sauvignon. Grapes from vineyard Vrbové located in southwestern Slovakia were used for the research in 2020. The identification of filamentous fungi was performed using the macroscopic and microscopic observations and yeasts were identified by MALDI-TOF Mass Spectrometer. A total of 642 isolates were obtained. Grapes were rich in diversity of filamentous fungi (13 genera) and must on yeasts (8 genera). Penicillium, Botrytis, and Hanseniaspora uvarum were identified in both grapes and must. Three of the fungal genera identified by conventional or molecular techniques from the surface of red grape varieties were predominant: Alternaria (26%), Botrytis (21%), and Issatchenkia terricola (13%), two from endogenous mycobiota: Hanseniaspora uvarum (45%) and Botrytis (17%), four from the surface of white grape varieties: Penicillium (25%), Botrytis (21%), Alternaria (16%) and Hanseniaspora uvarum (15%), and three from endogenous mycobiota: Botrytis (44%), Hanseniaspora uvarum (23%) and Alternaria (20%). Saccharomyces cerevisiae, Candida krusei, C. utilis, and Cryptococcus neoformans were identified only in wine.
ANALISIS PROSEDUR PEMBIAYAAN DAN MANAJEMEN RISIKO PADA PERUSAHAAN PEER TO PEER (P2P) LENDING SYARIAH DI INDONESIA
Authors: Iskandar Evy , Ayumiati Ayumiati , Katrin Novita 
Published: April 2021

This study to examines the procedures for financing and risk management in Peer to Peer (P2P) lending company in Indonesia with a case study at PT. Ammana Fintek Syariah as a Sharia P2P lending company that was the first registered in Financial Services Authorization (OJK), which was established to free access to Micro, Small and Medium Enterprises (MSMEs) finance from loan sharks and usury interest. This study uses qualitative methods, primary data in research is based the direct information from company management as a stake holder. The results of this study indicate that the application of company financing procedures is carried out with two patterns, in the direct pattern that involving partners (BMT) and in the non-direct pattern carried out directly by the team of PT. AFS. While the application of risk management is mitigation by partners and internal management of PT.AFS to conduct early prevention of the risks to be faced, and in handling the problem of financing jams, the company opens a deliberation room for consensus on the actions of the settlement of both parties.

Keywords: Financing Procedure, Risk Management, peer to peer

Abstrak
Penelitian ini mengkaji tentang prosedur pembiayaan dan manajemen risiko pada perusahaan Peer to Peer (P2P) lending di Indonesia dengan studi kasus pada PT.Ammana Fintek Syariahsebagai perusahaan P2P lending syariah pertama kali terdaftar di Otorisasi Jasa Keuanga (OJK), yang didirikan untuk membebaskan akses untuk keuangan UMKM dari pola rentenir dan bunga riba. Penelitian ini menggunakan metode kualitatif, data primer dalam penelitian adalah informasi langsung dari manajemen perusahaan sebagai stake holder. Hasil penelitian ini menunjukkan bahwa penerapan prosedur pembiayan perusahaan dilakukan dengan dua bentuk yaitu pola directyang melibatkan mitra (BMT) dan non direct dilakukan langsung oleh tim PT. AFS. Sedangkan penerapan manajemen risikonya adalah dengan model mitigasi oleh mitra dan pengelolaan internal PT.AFS untuk melakukan pencegahan awal terhadap risiko yang akan dihadapi, dan penanganan masalah pembiayaan yang macet perusahaan membuka ruang musyawarah untuk mufakat terhadap tindakan penyelesaian kedua belah pihak.

Kata Kunci:Prosedur Pembiayan, Manajemen Risiko, Peer To Peer.
PENGUKURAN KUALITAS JASA PELAYANAN KB MANDIRI DI PROVINSI ACEH
Authors: Zulkifli Zulkifli , Amri Amri , Munawar Eddy , Anwar Anwar 
Published: April 2021

This study aims to measure the quality of family planning services in the province of Aceh which can later be useful for BKKBN policy in the context of determining the policy of providing unpaid contraception. The location of the study is Bireuen district and North Aceh district as regency areas with the highest number of active family planning participants according to the contraceptive method in the Private Service Line in March 2018. The number of samples used were 75 fertile age couples (PUS) obtained through the Multistage purposive sampling method followed by the snowball sampling method. Data were analyzed using Importance Performance Analysis (IPA) and Cartesian Diagrams. The results obtained are that all indicators measured show a high level of satisfaction on Mandiri (paid) KB services so it is recommended that the BKKBN can improve free KB services or otherwise prepare alternatives to stop free KB services.
La lavada de ropa de las imágenes religiosas en Cacaopera: bendición a las venas de la tierra
Authors: Osegueda Carlos Felipe , Rojas de Boscaino Delmy Rossana , Ramírez José Rafael 
Published: April 2021

El presente artículo forma parte de la investigación de en el aula, de la asignatura de antropología de la religión, en la Universidad Tecnológica de El Salvador (UTEC), se estudió el ritual de la lavada de la ropa de las imágenes del pueblo de Cacaopera, Departamento de Morazán, lo expuesto pretende poner en evidencia la necesidad de proteger el patrimonio tangible e intangible del pueblo de Cacaopera, contribuyendo a su divulgación por medio de la descripción de la lavada y un análisis de sus significados, visto desde la perspectiva Emic (desde los actores) y Etic (desde el investigador), como expresión vivencial que contribuyen al rostro identitario salvadoreño.
Aportes de los equipos de salud en la prevención de las violencias y promoción de la salud de los varones adolescentes de la Ciudad Autónoma de Buenos Aires
Authors: Tajer Débora , Reid Graciela , Gaba Mariana , Fernández-Romeral Juliana , Saavedra Lucía , Cuadra María Eugenia , Solís Mónica , Lo Russo Alejandra 
Published: April 2021

El proyecto de investigación “Barreras de género en la prevención y atención de la salud de los varones adolescentes: significados y prácticas de usuarios y profesionales de la salud” tiene el objetivo de actualizar el estado del arte sobre la salud de los varones adolescentes desde una perspectiva de género, salud colectiva y subjetividad y producir insumos para establecer acciones preventivas en este campo desde una perspectiva del derecho a la salud. Una de las hipótesis de la investigación es que existe una falta de identificación y de promoción de la detección precoz de las conductas de riesgo ligadas a la construcción de la masculinidad que se pueden ir consolidando en la adolescencia y expone a los varones (y a las mujeres y varones de su entorno) a riesgos y vulnerabilidades específicas. Como parte de sus resultados esta investigación aporta insumos específicos para pensar el espacio de las consultas en salud como una oportunidad para generar estrategias de promoción de conductas alternativas y de prevención de las violencias de género, específicamente la sexual. Algunos hallazgos son que la falta de preparación de los/as profesionales de salud para atender a los usuarios varones y la escasez y ausencia de modelos, programas y materiales específicos dirigidos, desde una perspectiva de género, hacia el cuidado y la prevención de la salud en varones adolescentes son un obstáculo. Por otro lado, la posibilidad que los adolescentes abandonen un comportamiento riesgoso está relacionada estrechamente con la posibilidad de que se le ofrezcan alternativas de satisfacción valiosas para ellos.
Imigração senegalesa para a França e para o Brasil: uma comparação de discursos midiáticos
Authors: Almeida Letícia Núñez , Dutra Fernández Thais , Oviedo Pérez José 
Published: April 2021

O presente artigo analisa como os meios de comunicação abordam a imigração da população senegalesa em direção ao Brasil e à França. Propõe-se estudar o discurso adotado pela mídia local, sobretudo a impressa, no processo de caracterizar e apresentar a imigração contemporânea nessas duas sociedades de acolhida. Tem-se como hipótese de investigação que os meios de comunicação brasileiros e franceses rotulam a imigração senegalesa através de discurso discriminatório, baseado em preconceitos raciais, religiosos e/ou sexuais. Para tanto, utilizou-se como método a análise de discurso em aproximadamente 100 reportagens de jornais brasileiros e franceses entre 2010-2018, para assim examinar como os discursos midiáticos se aproximam e/ou se distanciam. Conclui-se que a imigração continua sendo um processo contestado nesses dois países, sujeito ao efeito de legados históricos como a escravidão e o colonialismo. Palavras-chave: imigração senegalesa; discursos midiáticos; Brasil; França.
Unraveling the genetic diversity and structure ofQuercus liaotungensispopulation through analysis of microsatellite markers
Authors: Guo Bin , Hao Xiangchun , Han Lijun , Zhai Yu , Zhou Shuai , Chen Si , Ren Da , An Xinmin 
Published: April 2021

BackgroundQuercus liaotungensisKoidz. is an ecologically and economically important tree species widely distributed in Northern China. However, the effective assessment, utilization, and protection ofQ. liaotungensisresources remain unexplored.MethodsIn total, 120 samples obtained from 12Q. liaotungensispopulations of Northern China were investigated for genetic diversity and structure using 19 simple sequence repeat (SSR) primer pairs.ResultsThe total number of alleles detected was 293, the average number of effective allele (Ne) was 6.084, the genetic differentiation coefficient (Fst) was 0.033, and the mean observed heterozygosity (Ho) and expected heterozygosity (He) were 0.690 and 0.801, respectively. Moreover, analysis of molecular variance (AMOVA) showed a 5.5% genetic variation among 12Q. liaotungensispopulations, indicating that a high level of genetic diversity and a low degree of genetic differentiation amongQ. liaotungensispopulations. STRUCTURE and cluster analysis divided the 12Q. liaotungensispopulations into the following three subpopulations: Bashang Plateau subpopulation (SH), Liaodong Peninsula subpopulation (NC), and Loess Plateau subpopulation (other 10 populations). The cluster analysis based on 19 climatic factors was consistent with the genetic structure. A positive correlation was found between genetic distance and geographical distance (r = 0.638,p = 0.028) by the Mantel test, and two boundaries were found among the 12Q. liaotungensispopulations by the Barrier analysis, indicating thatQ. liaotungensispopulations existed isolated by geographical distance and physical barrier.ConclusionThis study suggests that geographical isolation, physical barrier, climatic types, and natural hybridization promote the formation of genetic structures, which can contribute to future protection and genetic improvement ofQ. liaotungensis.
Transient postprandial increase in intact circulating fibroblast growth factor-21 levels after Roux-en-Y gastric bypass: a randomized controlled clinical trial
Authors: Nielsen Mette S. , Søberg Susanna , Schmidt Julie B. , Chenchar Anne , Sjödin Anders , Gillum Matthew P. 
Published: April 2021

Background
Despite a consistent link between obesity and increased circulating levels of fibroblast growth factor-21 (FGF21), the effect of weight-loss interventions on FGF21 is not clear. We aimed to determine the short- and long-term effects of Roux-en-Y gastric bypass (RYGB) on intact plasma FGF21 levels and to test the hypothesis that RYGB, but not diet-induced weight loss, increases fasting and postprandial responses of FGF21.

Method
Twenty-eight participants with obesity followed a low-calorie diet for 11 weeks. The 28 participants were randomized to undergo RYGB surgery at week 8 (RYGB group, n = 14), or to a control group scheduled for surgery at week 12 (n = 14). Fasting levels of intact, biologically active FGF21 (amino acids 1-181) and its postprandial responses to a mixed meal were assessed at week 7 and 11, and 78 weeks (18 months) after RYGB.

Results
At week 11 (3 weeks after RYGB), postprandial responses of intact FGF21 were enhanced in participants undergoing surgery at week 8 (change from week 7 to 11: P = 0.02), whereas no change was found in non-operated control participants in similar negative energy balance (change from week 7 to 11: P = 0.81). However, no between-group difference was found (P = 0.27 for the group-week-time interaction). Fasting, as well as postprandial responses in intact FGF21, were unchanged 18 months after RYGB when both the RYGB and control group were collapsed together (change from week 7 to 78 weeks after RYGB: P = 0.17).

Conclusion
Postprandial intact FGF21 levels were enhanced acutely after RYGB whereas no signs of sustained changes were found 18 months after surgery. When comparing the acute effect of RYGB with controls in similar negative energy balance, we failed to detect any significant differences between groups, probably due to the small sample size and large inter-individual variations, especially in response to surgery.
Comparison of Operative Outcomes Among Laparoscopic, 3D-Laparoscopic, and Robotic Gastrectomy for Distal Gastric Cancer
Authors: Wu Tung-Yen , Liu Yen-Ling , Huang Kuo-Hung , Fang Wen-Liang , Lo Su-Shun , Li Anna Fen-Yau , Wu Chew-Wun , Shyr Yi-Ming 
Published: April 2021

Objective
Minimally invasive surgery has become popular in the treatment of gastric cancer.

Background
Few reports have compared operative outcomes among laparoscopic, 3-dimensional (3D)-laparoscopic, and robotic gastrectomy for distal gastric cancer.

Methods
Between August 2011 and June 2020, a total of 245 patients underwent laparoscopic (n = 129), 3D-laparoscopic (n = 55), or robotic (n = 61) gastrectomy for distal gastric cancer; the clinicopathologic characteristics and operative outcomes were compared among groups.

Results
Compared with the laparoscopic group, the 3D-laparoscopic and robotic groups were associated with more D2 lymphadenectomy, higher medical costs, and a longer operative time, whereas the number of retrieved lymph nodes and surgical complications were similar among the 3 groups. For patients receiving D2 lymphadenectomy, the robotic group was associated with higher medical costs and longer operative time than the other 2 groups; patients with high body mass index (high BMI) had a longer operative time than patients with low BMI in the laparoscopic group, which was not significantly different between patients with low or high BMI in both the 3D-laparoscopic and robotic groups. For patients with low BMI, the medical costs were higher and the operative time was longer in the robotic group than the other 2 groups. For patients with high BMI, the robotic group was associated with higher medical costs, and longer operative time and postoperative hospital stay than the other 2 groups.

Conclusions
3D-laparoscopic gastrectomy was associated with affordable medical costs, comparable lymphadenectomy, and similar surgical outcomes compared with robotic gastrectomy.
Electrooxidative Metal‐Free Cyclization of 4‐Arylaminocoumarins with DMF as C1‐Source
Authors: Weng Yiyi , Chen Hantao , Li Nanhui , Yang Long , Ackermann Lutz 
Published: April 2021

AbstractAn environmentally‐benign electrochemical approach for the construction of quinoline derivatives employing N,N‐dimethylformamide (DMF) as the methine source has been devised by cyclization of 4‐(phenylamino)‐2H‐chromen‐2‐ones. In a user‐friendly undivided cell, 6H‐chromeno[4,3‐b]quinolin‐6‐ones were obtained under chemical oxidant‐free and transition‐metal‐free conditions in 43–92% yields with high functional tolerance.magnified image