bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influencia de la arquitectura vernácula en las bodegas de vino mexicanas
Authors: Fernandez Barberena Maria Jose 
Published: December 2021

Al vivir el ser humano en un lugar fijo, construyó ciertos espacios para cubrir sus necesidades, por lo que buscó emplear recursos naturales a su alcance, como adobe, madera, piedras, tierra y variados elementos vegetales y aún animales con técnicas sencillas. Este tipo de construcción es primigenia de la humanidad y en su composición y forma manifiesta las necesidades de supervivencia básicas del ser humano, se acopla a su entorno y a la cultura a la que pertenece. Sus técnicas de construcción se fueron ajustando a los materiales disponibles, a la adaptación de la mano de obra y a las herramientas a su alcance y, por otro lado, a los desastres naturales como inundaciones, incendios o sismos que los forzaron a adecuarse.
En la actualidad se le está dando importancia a las edificaciones vernáculas y son objeto de estudio; de tal manera que muchos arquitectos contemporáneos están retomando el concepto con el fin de recuperar los valores arquitectónicos de una región y construir aprovechando los recursos disponibles, adaptándose al medio físico. En este trabajo se pretende profundizar en el concepto de arquitectura vernácula y los elementos que la conforman, de forma que se pueda identificar las características vernáculas que han influido en la arquitectura contemporánea de algunos viñedos en México.
A Proposed Method for Residual Citation Allocation Based on Citation Contexts’ Similarity
Authors: Asubiaro Toluwase Victor , Ajiferuke Isola 
Published: December 2021

Abstract
This article proposes an approach for allocating residual citations to scientific publications and demonstrating this proposed approach with a sample of biomedical publications. Residue citations (i.e., citations that are lost due to citation practices termed “Obliteration by Incorporation” and the “Palimpsestic Syndrome”) in consequent citations in the second, third or nth generations are then reconstituted. The proposed approach takes into account citation contexts (i.e., the contribution of a cited publication) for allocating residual citation. The proposed method for allocating residual citation is based on the similarity between the citation contexts of a publication and those of its nth generation citations in their n+1th generation citations. The proposed method was demonstrated using a sample with ten base articles and their five generations of citations, from which 5,272 citation context pairs were obtained. The proposed indirect citation weighting was compared with the existing cascading citation weighting method using one T-test. Statistical tests were also performed to understand the differences in the residual citations from one generation to the other. Like the cascading citation system, residual citations from articles to their generations of citations decreased as the number of generations increased. However, residue citations accrued to publications at all the generations were statistically different between the proposed residual citation and the cascading citation system. This study proposes a method for assessing scientific communication based on the contribution of scientific publications beyond the conventional direct citation.
Early Onset of Intrahepatic Cholestasis of Pregnancy: a Case Report
Authors: Stavinskaia Liudmila , Cemortan Maria , Cernetchi Olga 
Published: December 2021

Abstract
Intrahepatic cholestasis of pregnancy is a disorder, characterized by pruritus and elevated liver function tests. Associated with a high incidence of adverse perinatal outcomes, intrahepatic cholestasis of pregnancy (ICP) requires thorough attention in clinical practice. In addition, there is a high rate of stillbirth in cases of ICP. Women with ICP should be informed of the inability to predict stillbirth. Multi-disciplinary cooperation is critical for managing the condition and ensuring better pregnancy outcomes.
Nonlinear Error Compensation Based on the Optimization of Swing Cutter Trajectory for Five-Axis Machining
Authors: Chen Liangji , Tang Jinmeng , Wu Wenyi , Wei Zisen 
Published: December 2021

Abstract
In order to solve the problem of deviation between actual and theoretical machining paths due to the presence of rotation axis in five-axis machining, an interpolation algorithm based on the optimization of swing cutter trajectory and the method of corresponding nonlinear error compensation are proposed. Taking A-C dual rotary table five-axis machine tool as an example, the forward and reverse kinematic model of the machine tool is established according to the kinematic chain of the machine tool. Based on the linear interpolation of rotary axis, the generation mechanism of nonlinear error is analyzed, the modeling methods of cutter center point and cutter axis vector trajectory are proposed respectively, and the parameterized model of swing cutter trajectory is formed. The formula for the nonlinear error is obtained from the two-dimensional cutter center point trajectory. According to the established model of swing cutter trajectory, the synchronous optimization method of cutter center point trajectory and cutter axis vector trajectory is proposed, and the nonlinear error compensation mechanism is established. First, pre-interpolation is performed on the given cutter location data to obtain a model of the swing cutter trajectory for each interpolated segment. Then the magnitude of the nonlinear error is calculated based on the parameters of the actual interpolation points during formal interpolation, and the interpolation points with large errors are compensated for the nonlinear error. The simulation results show that the proposed method can effectively reduce the impact of nonlinear errors on machining, and is of high practical value for improving the accuracy of cutter position and the quality of complex free-form machining in five-axis machining.
Ligand-specific conformational change drives interdomain allostery in Pin1
Authors: Vogeli Beat , Born Alexandra , Soetbeer Janne , Henen Morkos , Breitgoff Frauke , Polyhach Yevhen , Jeschke Gunnar 
Published: December 2021

Abstract
Pin1 is a two-domain cell regulator that isomerizes peptidyl-prolines. The catalytic domain (PPIase) and the other ligand-binding domain (WW) sample extended and compact conformations. Ligand binding changes the equilibrium of the interdomain conformations, but the conformational changes that lead to the altered domain sampling were unknown. Prior evidence has supported an interdomain allosteric mechanism. We recently introduced a magnetic resonance-based protocol that allowed us to determine the coupling of intra- and interdomain structural sampling in apo Pin1. Here, we describe ligand-specific conformational changes that occur upon binding of pCDC25c and FFpSPR. pCDC25c binding doubles the population of the extended states compared to the virtually identical populations of the apo and FFpSPR-bound forms. pCDC25c binding to the WW domain triggers conformational changes to propagate via the interdomain interface to the catalytic site, while FFpSPR binding displaces a helix in the PPIase that leads to repositioning of the PPIase catalytic loop.
P. Falciparum Community Prevalence and Health Seeking Behaviors in Rural Sussundenga District, Mozambique
Authors: Earland Dominique E , Bibe Albino Francisco , Novela Anísio , Ferrão João , Searle Kelly M 
Published: December 2021

Abstract
Background: The large-scale effectiveness of malaria control interventions is differential at international border settings with varying policies, such as that between Mozambique and Zimbabwe. Impacts of nationally directed malaria control interventions hinge on understanding malaria transmission and prevention at the community level along international borders. Thus far, few studies have focused on central Mozambique. Our aim was to describe community level P. falciparum transmission dynamics and health seeking behaviors among residents of Sussundenga, Mozambique, a rural village bordering Zimbabwe in Manica Province with high malaria incidence reported at the Sussundenga-Sede health center (RHC). Methods: We conducted a cross-sectional community-based survey from December 2019 – February 2020. We used a random household sampling method, based on enumerated households from satellite imagery. All consenting participants completed a survey about malaria risk, prevention, and health seeking-behaviors, and received a P. falciparum malaria rapid diagnostic test (RDT). Results: We enrolled 96 households with 358 individuals. The P. falciparum prevalence was 31.6% (95% CI [26.6-36.5]). Ninety-three percent of participants reported using the Sussundenga-Sede RHC for healthcare. Sixty-six percent of participants (N=233) experienced at least one malaria symptom in the past month, with self-reported fever most frequently reported (19.3%). Of these, 176 (76.5%) sought care in a health facility and 174 (79%) received an RDT with 130 (63%) positive results. Of those with a positive RDT, 127 (97%) received Coartem®. Following treatment, 123 (97%) participants' symptoms resolved within a median of 3 days (IQR: 3-5) ranging from 2-14 days. In this high transmission setting, a high proportion of participants recognized malaria related symptoms then received a proper diagnostic test and treatment in a health facility. Conclusions: Future interventions that leverage this health seeking behavior and strengthen health systems for community interventions will improve malaria control and inform the efficacy of potential interventions at this particular international border.
Understanding Drivers of Vaccine Hesitancy among Pregnant Women in Nigeria: A Longitudinal Study
Authors: Adeyanju Gbadebo , Betsch Cornelia , Sprengholz Philipp 
Published: December 2021

Abstract
Background: Vaccine-preventable diseases are major contributors to the disease burden in Sub-Saharan Africa, accounting for many childhood illnesses, disabilities, and mortality. There is dearth of knowledge on the drivers of vaccine hesitancy in Nigeria and the extent of its impact on coverage. Pregnant women are a particularly important vulnerable and at-risk group and, additionally, very relevant for childhood vaccination decisions. However, this group is understudied in Nigeria. This study’s aims are to adapt Confidence, Complacency, Constraints, Calculation, and Collective Responsibility, also known as the 5C psychological antecedence scale for the Nigerian context and to measure vaccine hesitancy to predict the intention to vaccinate among pregnant women (prenatal) and subsequent vaccination behavior (postnatal). Method: It is a longitudinal study that used multi-stage sampling procedure. One healthcare facility was selected from each district in five regional clusters, from which 255 pregnant women were randomly drawn. A standardized questionnaire was used to collect data on demographic characteristics, sources of vaccination information, and the 5C psychological antecedents of vaccination. Additional variables tested included the importance of religion, masculinity, and rumor/conspiracy theory. The scale’s reliability was explored, and a backward elimination regression analysis was performed to identify the major determinants of childhood vaccination intention among pregnant women (T1) and their postnatal behavior (T2). Results: The prenatal (T1) findings revealed low reliability of the 5C subscales in Nigeria’s setting. Pregnant women’s intention to vaccinate unborn children was lower if they were Muslims, had lower confidence in public authorities or the health system, if husband approval was important for vaccination, and if they believed in rumor. Postnatal (T2) findings revealed that vaccination was more likely to follow mothers’ religious beliefs, when confidence in vaccine effectiveness was high and when mothers felt responsible for the collective. However, higher levels of everyday stress (constraints) were related to less vaccination behavior, and intention did not predict actual vaccination behavior. Conclusion: The 5C scale is incompletely adaptable in Nigeria but is a better tool for measuring vaccination behavior than intention. Overall, the vaccination intention did not predict behavior among pregnant women. The additional variables are good instruments that need further exploration.
Homogeneous Surrogate Virus Neutralization Assay to Rapidly Assess Neutralization Activity of Anti-SARS-CoV-2 Antibodies
Authors: Kim Sun Jin , Yao Zhong , Marsh Morgan , Eckert Debra , Kay Michael , Lyakisheva Anna , Pasic Maria , Bansal Aiyush , Birnboim Hyman , Jha Prabhat , Delgado Julio , Elgort Marc , Campbell Robert , Middleton Elizabeth , Stagljar Igor , Owen Shawn 
Published: December 2021

Abstract
The COVID-19 pandemic triggered the development of numerous diagnostic tools to monitor infection and to determine immune response. Although assays to measure binding antibodies against SARS-CoV-2 are widely available, more specific tests measuring neutralization activities of antibodies are immediately needed to quantify the extent and duration of protection that results from infection or vaccination. We previously developed a ‘Serological Assay based on a Tri-part split-NanoLuc® (SATiN)’ to detect antibodies that bind to the spike (S) protein of SARS-CoV-2. Herein, we expand on our previous work and describe a reconfigured version of the SATiN assay that can measure neutralization activity of antibodies directly from convalescent or vaccinated sera. The sensitivity is comparable to cell-based pseudovirus neutralization assays but with significantly shorter preparation and assay run time. As the assay is modular, we further demonstrate that Neutralization SATiN (Neu-SATiN) enables rapid assessment of the effectiveness of vaccines and level of protection against existing SARS-CoV-2 variants of concern and can therefore be readily adapted for emerging variants.
Automatic Air Volume Control System for Ventilation of Two Patients Using a Single Ventilator: A Large Animal Model Study
Authors: Zielinski Krzysztof , Lisowska Barbara , Siewruk Katarzyna , Sady Maria , Ferenc Karolina , Barwijuk Maciej , Olszewski Jaroslaw , Anusz Krzysztof , Jablonski Artur , Gajewska Magdalena , Okrzeja Piotr , Michnikowski Marcin , Pijanowska Dorota , Pluta Krzysztof , Remiszewska Elzbieta , Darowski Marek , Zabielski Romuald , Liebert Adam , Kramek-Romanowska Katarzyna , Stecka Anna , Kozarski Maciej , Pasledni Raman , Gajewski Zdzislaw , Ladyzynski Piotr 
Published: December 2021

Abstract
The COVID-19 pandemic outbreak led to a global ventilator shortage. Hence, different strategies to use a single ventilator to support multiple patients are considered. A mechatronic system Ventil divides and automatically controls gas volume pumped through two channels and was successfully validated in independent lung ventilation. We used Ventil in a series of experiments on a large animal model to verify its usability for ventilation in two patients using a single ventilator. The results of investigations on 12 pigs showed that the physiological level of respiratory parameters was maintained for 24 hours. Application of Ventil did not lead to injuries in the lungs, as indicated by CT scan analysis. We conclude that ventilation using Ventil can be considered safe in patients subjected to deep sedation without spontaneous breathing efforts.
Initial Succession After Wildfire in Dry Boreal Forests of Northwestern North America
Authors: Dawe Denyse , Parisien Marc-André , Dongen Angeline Van , Whitman Ellen 
Published: December 2021

Abstract
Wildfires in the boreal forest of North America are generally stand renewing, with the initial phase of vegetation recovery often governing the vegetation trajectory for decades. Here, we investigate post-fire vegetation changes in dry boreal forests of the Northwest Territories, Canada, during the first five years following the unusually severe 2014 wildfire season. We sampled post-fire tree regeneration and the overall plant community at one, three, and five years post-fire across different fire severities and stand types within fires that burned in 2014. Post-fire trajectories of tree recruitment, cover by plant functional types, and plant diversity varied widely among sampled stands, as well as among years post-fire. Tree seedling density reaches relative equilibrium by three years post-fire, whereas trends in understory plant cover and understory species assemblages suggest an ongoing change that will extend beyond five years of observation. In almost half of sampled stands, the composition of recruited trees differs from that of the pre-fire stand, suggesting a change in tree-species dominance. An analysis of regional climate reveals a significant, albeit spatially variable, warming and drying trend that will further accelerate forest-stand transformation through both climate drivers of plant community composition and indirectly through increasing fire activity. While the 2014 wildfires enhanced the structural and compositional heterogeneity of the region, they also triggered vegetation changes that are likely to be persistent. As such, this study exemplifies the speed and variability that characterizes post-fire stand development in a strongly moisture-limited part of North America.
Treatment Outcome of Tardy Ulnar Nerve Palsy Associated with Traumatic Cubitus Valgus by Supracondylar Shortening Wedge Rotary Osteotomy and Ulnar Nerve in Situ Tension Release
Authors: Fan Chenchen , Yushan Maimaiaili , Liu Yanshi , Bahesutihan Yemenlehan , Liu Kai , Yusufu Aihemaitijiang 
Published: December 2021

Abstract
Background
Tardy ulnar nerve palsy is a common late complication of traumatic cubitus valgus. At present, the treatment of tardy ulnar nerve palsy associated with traumatic cubitus valgus is still controversial, whether these two problems can be corrected safely and effectively in one operation is still unclear. To investigate the supracondylar shortening wedge rotary osteotomy combined with in situ tension release of the ulnar nerve in the treatment of tardy ulnar nerve palsy associated with traumatic cubitus valgus.
Methods
Between 2012 and 2019, 16 patients who had traumatic cubitus valgus deformities with tardy ulnar nerve palsy were treated with simultaneous supracondylar shortening wedge rotary osteotomy and ulnar nerve in situ tension release. we compared a series of indicators of preoperative and postoperative follow-up for at least 24 months, (1) elbow range of motion; (2) the radiographic correction of the preoperative and postoperative humerus-elbow-wrist angles; (3) the static two-point discrimination and grip strength; and (4) the preoperative and postoperative DASH scores of upper limb function. The minimum follow-up was 24 months postoperative (mean, 33 months; range, 24ཞ44 months).
Results
The mean ROM was improved from 107 ° preoperatively to 122 ° postoperatively (P = 0.001). The mean preoperative elbow wrist angle was 24.6 °, and the mean postoperative humerus-elbow wrist angle was 12.1 ° (P < 0.001). The average grip strength and static two-point discrimination improved from 28 kg force and 8 mm to 21 kg force and 4.0 mm (P < 0.001 and P < 0.001, respectively). The ulnar nerve symptoms were improved in all patients except one. The mean HASH score improved from 29 to 16 (P < 0.001).
Conclusion
Supracondylar shortening wedge rotary osteotomy combined with in situ tension release of ulnar nerve is an effective method for the treatment of traumatic cubitus valgus with tardy ulnar nerve palsy, which restored the normal biomechanical characteristics of the affected limb and improved the elbow joint function.
N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA
Authors: Zhang Xiang , Yin Huilong , Zhang Xiaofang , Jiang Xunliang , Liu Yongkang , Peng Yingran , Li Da , Yu Yanping , Zhang Jinbao , Cheng Shuli , Yang Angang , Zhang Rui 
Published: December 2021

Abstract
Hepatic glycogen is the main source of blood glucose and controls the intervals between meals in mammals. Hepatic glycogen storage in mammalian pups is insufficient compared to their adult counterparts; however, the detailed molecular mechanism is poorly understood. Here, we showed that, similar to glycogen storage pattern, N6-methyladenosine (m6A) modification in mRNAs gradually increases during the growth of mice in liver. Strikingly, in the liver-specific Mettl3 knockout mice, loss of m6A modification disrupts liver glycogen storage. On the mechanism, we screened and identified that glycogen synthase 2 (Gys2) plays a critical role in m6A-mediated regulation of liver glycogen storage. Furthermore, IGF2BP2, as a “reader” of m6A, stabilizes the mRNA of Gys2. More importantly, reconstitution of GYS2 rescues liver glycogenesis in Mettl3-cKO mice. Collectively, a METTL3-IGF2BP2-GYS2 axis, in which METTL3 and IGF2BP2 regulate glycogenesis as “writer” and “reader” respectively, plays a critical role on maintenance of liver glycogenesis in mammals.
Carbon and Energy Intensity of the USA and Germany. A LMDI Decomposition Approach and Decoupling Analysis.
Authors: Koilakou Eleni , Hatzigeorgiou Emmanouil , Bithas Kostas 
Published: December 2021

Abstract
The present study investigates the driving factors of energy and carbon intensity of the great economies of the USA and Germany, being two economies with different structures and dependencies on energy while they are among the world’s economic and geopolitical leading players. Both Decoupling and Decomposition Analysis are applied to identify and rank factors defining Carbon and Energy Intensity during the period from 2000 to 2017, with the so-called financial crisis being within this period. The decoupling analysis denotes that these advanced economies should enhance their decoupling efforts, while decomposition analysis confirms the leading role of energy intensity in CO2 emissions, next the income and the energy mix emerge as important factors with population trend to be an additional factor only in the USA. Finally, conclusions and relevant policy suggestions are presented.
Rituximab/Bendamustine or Rituximab/Ifosfamide/Carboplatin/Etoposide as Second-Line Therapy for Relapsed/Refractory Diffuse Large B-Cell Lymphoma: A Real-World Analysis
Authors: Wang Yu-Hung , Su Ching-Yen , Chen Li-Chin , Yao Ming , Ko Bor-Sheng 
Published: December 2021

Abstract
Rituximab/bendamustine (RB) and rituximab/ifosfamide/carboplatin/etoposide (R-ICE) are commonly used to treat relapsed/refractory diffuse large B-cell lymphoma (DLBCL), although their effectiveness has not been compared in real-world practice. This study evaluated data from DLBCL patients who relapsed after or were refractory to first-line therapy in an electronic health record (EHR)-derived database between 2011 and 2018. One hundred thirty-seven patients using RB and 270 patients using R-ICE were included for analysis. Transplantation after second-line therapy was considered a censored event in the time-to-event analyses. Patients in the RB group were older and had poorer performance status while there were no significant differences in stage, cell of origin, and double-/triple-hit subtypes. Relative to the R-ICE group, the RB group had significantly longer time-to-next-treatment (TTNT) and overall survival (OS). Subgroup analyses revealed that patients who were <70 years or had better performance status consistently had better TTNT and OS if they had received RB. Patients who had disease progression within 12 months after induction chemotherapy had a significantly inferior prognosis, regardless of the salvage treatments. Multivariable analysis revealed that RB treatment independently predicted better TTNT and OS. These data indicate that RB may be an alternative to R-ICE as second-line therapy for selected DLBCL patients.