bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green Hydrotropes-Assisted Route: An Alternative Approach for Extracting Phytoconstituents and Associated Drug Delivery Systems
Authors: Tripathi Devika , Chaudhary Nandini , Wal Pranay , Rai Awani K. , Sahoo Jagannath 
Published: July 2021

:
Critically challenging tasks for the researchers are isolating and extracting chief active
medicinal phytoconstituents from existing herbal plants. The intricate extraction process usually involves
active plant and animal portions separated by selective solvents through various standard
procedures. Therefore, most of the products contained the complex metabolites mixtures, making
the extraction process involved in separating these products increasingly tricky, thus resulting in
lesser yield. Therefore, an alternative strategy suitable for green extraction routes has recently succeeded
as a sustainable resource with many advantages like high solvency, low toxicity, and low
impact in the environment, biodegradable, and helps recycle consumed solvents without showing
any detrimental effects on the environment.

:
The process of green hydrotrope-assisted extraction process persists a novel and promising methodology
that maximizes the yield of phytoconstituents in comparison to the conventional extraction
process by the commissioning of a variety of hydrotropes like sodium cumene sulfonate, sodium
alkyl-benzene sulfonates, and sodium butyl mono-glycol sulfate, involved in selective extraction of
water-insoluble phytoconstituents by the disorganization of the phospholipid bilayers by the hydrotrope,
through cell permeabilization, disruption of the cellulosic cell wall and, then possibly the
dissolution of the cellular contents.

:
The central point of this audit is the increase of the surrender of phytoconstituents from herbal
plants accomplished by considering green hydrotropic-assisted extraction process, an assignment
of carrying out the extraction of herbal plants sanctioning hydrotropes and its component. Using hydrotropes
for extracting the phytoconstituents has imperatively highlighted the conveyance frameworks
of separated extricated phytoconstituents from herbal plants and encourages the forwarding
of their bioavailability at distinctive target destinations.
3D Visual Motion Amplitude Tracking Simulation Method for Sports
Authors: Zhuo Ni , Sharma Anil 
Published: July 2021

Background:
The character motion of 3D animation production is difficult, and to solve
this problem, motion-pose capture technology is very effective. The workload of character motion
control is reduced by this technique and the animation development is improved. It is used in virtual
training grounds and real-time tracking of the motion. The complete contour features cannot be efficiently
acquired by the 3D visual motion technique. The 3D visual motion amplitude tracking method
in sports is studied in order to improve the training quality of athletes effectively. However,
when the current method is used for motion amplitude tracking, the markers in the adjacent monocular
sequence motion amplitude images cannot be calculated.

Methodology:
At this point, there is a problem of a large tracking error of 3D visual motion amplitude.
To this end, a 3D amplitude tracking method in sports based on inverse kinematics is proposed.
This method locates the marker points that appear in the adjacent monocular sequence motion
range and merges it with the rotation angle method to predict the position of the motion range
in the image.

Results:
The motion amplitude is obtained, and 3D visual motion amplitude is outside the optimization
area; this has been used as a basis to complete the tracking of the 3D visual motion amplitude in sports.

Conclusion:
Experimental simulation performed in MATLAB proves the high tracking accuracy of
the proposed method.
Graphic Design Method Based on 3D Virtual Vision Technology
Authors: Chen Yanlin , Zou Wei , Sharma Amit 
Published: July 2021

Background:
Computer vision studies and three-dimensional (3D) models are used to
restore two-dimensional (2D) images. Computer vision studies have been conducted in the computer
graphic field, and due to its broad applications, numerous related explorations have been performed.

Methodology:
To directly and effectively convey the design concept of the virtual vision technology,
the graphic design was changed from 2D to 3D, which broadened the graphic design development space.
Based on the 3D virtual vision and interactive design, this study constructed an interior design platform.
After the detailed introduction of the function design of the 3D virtual visual effect displays of the interior
design platform, the 3D virtual rendering functions of the interior design platform were designed.

Results:
When the traditional interior design platform was improved, panoramic information combined
with 3D virtual vision technology can be used to record and analyze the results and to generate
the corresponding image workflow for establishing a completely functional interior design platform.
Based on this, ordinary and interior design platforms were comparatively analyzed.

Conclusion:
The interior design platform can accurately determine the interior landscape position
and draw good 3D images.
Blood Glucose Lowering Effect by an Extract from Aronia (Aronia melanocarpa) - A Pilot Intervention Study
Authors: Berger Kirsten , Ostberg Potthoff Johanna Josefine , Bakuradze Tamara , Winterhalter Peter , Richling Elke 
Published: July 2021

Background:
The polyphenols from red fruits exhibit protective effects against degenerative
diseases, such as diabetes mellitus type 2, cardiovascular disease and others.

Objective:
In this small pilot intervention study with only ten volunteers, we investigated the influence
of phenolic extracts prepared from an aronia juice, and a red grape juice concentrate on peripheral
glucose, blood glucose, and insulin after the intake of a drink containing these extracts
plus maltodextrin and water.

Method:
Maltodextrin in water served as control; additionally, phenolic extracts from aronia or
grape juice were added. Blood samples were taken before ingestion of the bolus drink, and 30, 60,
90, 120, 180, 240, and 360 min after. Additionally, the peripheral glucose was measured continuously
using a commercially available sensor system.

Results:
In all ten volunteers, the intake of aronia extract (100 mg) reduced both, the peripheral glucose
and the blood glucose levels significantly (p≤0.05) in comparison to the control. Blood insulin
levels were not affected. Whereas the intake of red grape extract (120 mg) did not reduce the glucose
levels, but increased the insulin levels significantly.

Conclusion:
Our pilot study showed that even low amounts of a phenolic aronia extract could lower
the glucose absorption. Thus, due to the blood glucose lowering effects of aronia phenolics in
healthy volunteers, these preliminary results warrant further investigation in the frame of a follow-
up study with larger number of volunteers.
A Concise Overview of Biosensing Technologies for the Detection of
Alzheimer's Disease Biomarkers
Authors: Talebi Marjan , Esmaeeli Hadi , Talebi Mohsen , Farkhondeh Tahereh , Samarghandian Saeed 
Published: July 2021

Abstract:
Alzheimer's disease (AD) is a brain-linked pathophysiological condition with neuronal degeneration
and cognition dysfunctions and other debilitations. Due to the growing prevalence of AD,
there is a highly commended trend to accelerate and develop analytical technologies for easy, costeffective,
and sensitive detection of AD biomarkers. Biosensors are commanding analytical devices that
can conduct biological responses on transducers into measurable signals. This review focuses on up-todate
developmets, contests, and tendencies regarding AD biosensing principally, with the emphasis on
the exclusive possessions of nanomaterials. In the last decade, remarkable advancements have been
achieved to the progression of biosensors, predominantly optical and electrochemical, for the detection
of AD biomarkers. These analytical devices can assist the case finding and management of AD.
PE2LGP: tradutor de português europeu para língua gestual portuguesa em glosas
Authors: Gonçalves Matilde , Coheur Luisa , Nicolau Hugo , Mineiro Ana 
Published: July 2021

A língua gestual portuguesa, tal como a língua portuguesa, evoluiu de forma natural, adquirindo características gramaticais distintas do português. Assim, o desenvolvimento de um tradutor entre as duas não consiste somente no mapeamento de uma palavra num gesto (português gestuado), mas em garantir que os gestos resultantes satisfazem a gramática da língua gestual portuguesa e que as traduções estejam semanticamente corretas. Trabalhos desenvolvidos anteriormente utilizam exclusivamente regras de tradução manuais, sendo muito limitados na quantidade de fenómenos gramaticais abrangidos, produzindo pouco mais que português gestuado.
Neste artigo, apresenta-se o primeiro sistema de tradução de português para a língua gestual portuguesa, o PE2LGP, que, para além de regras manuais, se baseia em regras de tradução construídas automaticamente a partir de um corpus de referência. Dada uma frase em português, o sistema devolve uma sequência de glosas com marcadores que identificam expressões faciais, palavras soletradas, entre outras. Uma avaliação automática e uma avaliação manual são apresentadas, indicando os resultados melhorias na qualidade da tradução de frases simples e pequenas em comparação ao sistema baseline (português gestuado).
Este é, também, o primeiro trabalho que lida com as expressões faciais gramaticais que marcam as frases interrogativas e negativas.
The one-stage balloon dilatation with stone extraction for a combination of short urethral stricture and urethral stone in men
Authors: Alibekov M. M. , Katibov M. I. , Skorovarov A. S. , Gazimagomedov G. A. , Arbuliev K. M. , Savzikhanov R. T. , Kamalov K. G. 
Published: July 2021

Introduction. The literature highlights isolated studies examining approaches to the treatment of patients with a combination of stones and urethral stricture. In this regard, the problem of creating optimal tactics for managing such patients remains relevant.Purpose of the study. To analyze of own experience in treating patients with a combination of stricture and urethral stone using balloon dilation with urethral stone extraction.Materials and methods. The study included 7 men with short urethral stricture and stone, who underwent balloon dilation with urethral stone extraction. The age of patients ranged from 47 to 65 years (median - 52 years). The length of the urethral stricture ranged from 3 to 10 mm (median - 7 mm). The stricture in 2 (28.6%) cases was localized in the penile part of the urethra and 5 (71.4%) in the bulbous part. An etiology of urethral strictures: traumatic - in 2 (42.9%) patients, inflammatory - in 1 (14.3%) of cases, idiopathic - in 4 (57.1%) of cases. All patients had 1 urethral stone. The sizes of the stone ranged from 4 to 9 mm (median - 6 mm).Results. The operation time ranged from 11 to 19 min (median - 13 min). No patient had any intraoperative complications. UTIs was observed in the early postoperative period in 1 patient. The duration of postoperative hospital stay ranged from 1 to 5 days (median - 3 days). Postoperative follow-up ranged from 3 to 24 months (median - 14 months). Only 1 (14.3%) patient had a recurrence of urethral stricture 18 months after treatment. Thus, the overall treatment success in this group of patients was 85.7% (6/7).Conclusion. We used this conjunction approach when combined stricture and urethral stone in men for the first time in the world. It seems quite promising given the results.
Predicting the outcomes of a single endoscopic correction of vesicoureteral reflux using a dextranomer/hyaluronic acid copolymer: selection of the optimal predictive model
Authors: Dubrov V. I. , Sizonov V. V. , Kagantsov I. M. , Negmatova K. N. , Bondarenko S. G. 
Published: July 2021

Introduction. Endoscopic dextranomer/hyaluronic acid copolymer (DxHA) injection is the most commonly used minimally invasive method of surgical treatment of vesicoureteral reflux (VUR) in children.Purpose of the study. To estimate the accuracy of logistic prognostic models and artificial neural network for prediction a single endoscopic injection DxHA in VUR.Materials and methods. We used endoscopic DxHA in 582 patients (783 ureteric units) of all grades reflux (I - 20, II - 133, III - 443, IV - 187), 53 ureters had complete duplication. A total effectiveness of surgery was 53.2%. A binary logistic regression model and an artificial neural network (multilayer perceptron) were created, taking the following as independent variables: grade of reflux, the patient's age and sex, the ureteral duplication and ureteral dilatation index.Results. The univariate logistic regression showed that the selected predictors were strongly related to the outcome of the treatment. Binary logistic regression and neural network developed high accuracy of the predictions, area under ROC-curve was 0,7 for logistic regression model (a sensitivity of 70.7%, and a specificity of 66.3%) and 0.74 for artificial neural network (a sensitivity of 85.5%, a specificity of 65.3%). Synaptic neural network weights and logistic regression parameters were used in a scoring model to predict the outcome of a single endoscopic injection of DxHA in 2 independent hospitals. An outcomes analysis using predictive models in independent clinics showed a good quality of prediction both with the use of logistic regression (75% and 90% of the correct prognosis) and using a neural network (89.7% and 77% of the correct prediction).Conclusion. An artificial neural network and a binary logistic regression model are an effective tool to assist urologists in identifying and applying endoscopic treatments for VUR in children.
Percutaneous antegrade ureterolithotripsy for proximal ureteral stones: overview own experience use
Authors: Popov S. V. , Guseinov R. G. , Gadjiev N. K. , Davydov A. V. , Obidnyak V. M. , Barhitdinov R. S. , Perepelitsa V. V. 
Published: July 2021

Introduction. Currently, a large number of techniques are used in the treatment of patients with ureteral stones: extracorporeal shock-wave lithotripsy (ESWL), retrograde ureterolithotripsy (RULT), laparoscopic and retro-peritoneoscopic ureterolithotomy.Purpose of the study. To evaluate the possibilities and effectiveness of percutaneous antegrade ureterolithotripsy in the treatment of patients with proximal ureteral stones in comparison with transurethral contact ureterolithotripsy.Materials and methods. Twenty-eight patients with urolithiasis were treated, who underwent percutaneous antegrade ureterolithotripsy (PAULT) and 27 patients of the control group, who underwent RULT. All patients included in the study underwent a standard preoperative examination: complete blood count and urine analysis, bacteriological urine culture, biochemical tests, and X-ray research methods. Plain urography, renal ultrasound, computed tomography were used as imaging methods. The OLYMPUS URF-V3 8.4 Ch (Olympus Europa SE & Co. KG., Germany) video uretero-renoscope was used for PAULT in patients of the main group; lithotripsy was performed using thulium laser. The results of the study were subjected to statistical processing in order to determine the statistical significance of the differences between the data obtained. Quantitative variables were described using the arithmetic mean (M) and standard deviation (5). Qualitative variables were estimated by absolute and relative frequencies (percentages). The data were considered reliable at p values < 0.05.Results. The average time of surgical intervention in patients of the main group from the moment of placement of the ureteral catheter was 47 ± 12 min, with access without preliminary renal catheterization: 28 ± 4 min. Average time of surgical intervention in patients of the control group: 42.0 ± 10.7 minutes. The presented data indicate a significant (p < 0.05) greater cases' number of complete stone removal among patients of the main group compared with patients in the control group (74.0%).Conclusion. PAULT is preferred among choice treatment methods for patients with proximal ureteral large stones, for whom RULT and ESWL cannot be performed with a high level of “stone-free” rate and a minimum number of complications.
Clinically Applicable Segmentation of Head and Neck Anatomy for Radiotherapy: Deep Learning Algorithm Development and Validation Study
Authors: Nikolov Stanislav , Blackwell Sam , Zverovitch Alexei , Mendes Ruheena , Livne Michelle , De Fauw Jeffrey , Patel Yojan , Meyer Clemens , Askham Harry , Romera-Paredes Bernadino , Kelly Christopher , Karthikesalingam Alan , Chu Carlton , Carnell Dawn , Boon Cheng , D'Souza Derek , Moinuddin Syed Ali , Garie Bethany , McQuinlan Yasmin , Ireland Sarah , Hampton Kiarna , Fuller Krystle , Montgomery Hugh , Rees Geraint , Suleyman Mustafa , Back Trevor , Hughes Cían Owen , Ledsam Joseph R , Ronneberger Olaf 
Published: July 2021

Background
Over half a million individuals are diagnosed with head and neck cancer each year globally. Radiotherapy is an important curative treatment for this disease, but it requires manual time to delineate radiosensitive organs at risk. This planning process can delay treatment while also introducing interoperator variability, resulting in downstream radiation dose differences. Although auto-segmentation algorithms offer a potentially time-saving solution, the challenges in defining, quantifying, and achieving expert performance remain.

Objective
Adopting a deep learning approach, we aim to demonstrate a 3D U-Net architecture that achieves expert-level performance in delineating 21 distinct head and neck organs at risk commonly segmented in clinical practice.

Methods
The model was trained on a data set of 663 deidentified computed tomography scans acquired in routine clinical practice and with both segmentations taken from clinical practice and segmentations created by experienced radiographers as part of this research, all in accordance with consensus organ at risk definitions.

Results
We demonstrated the model’s clinical applicability by assessing its performance on a test set of 21 computed tomography scans from clinical practice, each with 21 organs at risk segmented by 2 independent experts. We also introduced surface Dice similarity coefficient, a new metric for the comparison of organ delineation, to quantify the deviation between organ at risk surface contours rather than volumes, better reflecting the clinical task of correcting errors in automated organ segmentations. The model’s generalizability was then demonstrated on 2 distinct open-source data sets, reflecting different centers and countries to model training.

Conclusions
Deep learning is an effective and clinically applicable technique for the segmentation of the head and neck anatomy for radiotherapy. With appropriate validation studies and regulatory approvals, this system could improve the efficiency, consistency, and safety of radiotherapy pathways.
Patient-Reported Experiences with Dialysis Care and Provider Visit Frequency
Authors: Brady Brian M. , Zhao Bo , Dang Bich N. , Winkelmayer Wolfgang C. , Chertow Glenn M. , Erickson Kevin F. 
Published: July 2021

Background and objectives
New payment models resulting from the Advancing American Kidney Health initiative may create incentives for nephrologists to focus less on face-to-face in-center hemodialysis visits. This study aimed to understand whether more frequent nephrology practitioner dialysis visits improved patient experience and could help inform future policy.

Design, setting, participants, & measurements
In a cross-sectional study of patients receiving dialysis from April 1, 2015 through January 31, 2016, we linked patient records from a national kidney failure registry to patient experience data from the In-Center Hemodialysis Consumer Assessment of Healthcare Providers and Systems survey. We used a multivariable mixed effects linear regression model to examine the association between nephrology practitioner visit frequency and patient-reported experiences with nephrologist care.

Results
Among 5125 US dialysis facilities, 2981 (58%) had ≥30 In-Center Hemodialysis Consumer Assessment of Healthcare Providers and Systems surveys completed between April 2015 and January 2016, and 243,324 patients receiving care within these facilities had Medicare Parts A/B coverage. Face-to-face practitioner visits per month were 71% with four or more visits, 17% with two to three visits, 4% with one visit, and 8% with no visits. Each 10% absolute greater proportion of patients seen by their nephrology practitioner(s) four or more times per month was associated with a modestly but statistically significant lower score of patient experience with nephrologist care by −0.3 points (95% confidence interval, −0.5 to −0.1) and no effect on experience with other domains of dialysis care.

Conclusions
In an analysis of patient experiences at the dialysis facility level, frequent nephrology practitioner visits to facilities where patients undergo outpatient hemodialysis were not associated with better patient experiences.
La participación de profesores en la resignificación del currículo de matemáticas: un desafío sociopolítico de la educación matemática crítica
Authors: García-Quintero Mónica María , Rendón-Mesa Paula Andrea , Villa-Ochoa Jhony Alexander 
Published: July 2021

El diseño del currículo de matemáticas, de una institución educativa de Medellín, está construido por orientaciones del macrocontexto, evidenciándose así una invisibilización de las prácticas socioculturales de la comunidad y dejando ver poco la participación de los profesores en la construcción de dicho currículo. Por ello, nos trazamos como objetivo identificar las motivaciones y los significados que tienen los profesores cuando participan en la resignificación del currículo de matemáticas. Para esto nos apoyamos de la perspectiva de la educación matemática crítica como una manera de investigar el currículo con un enfoque sociopolítico.
Este estudio lo realizamos bajo un paradigma cualitativo de la investigación crítica, ya que buscamos alternativas de transformación o posibilidades de “lo que podría ser”. Utilizamos las técnicas observación participante y grupos de discusión para coflexionar con los profesores temáticas construidas colectivamente de acuerdo con sus intereses, necesidades y prácticas socioculturales. Presentaremos un análisis parcial del trabajo de campo encaminados a responder la pregunta: ¿cuáles son las motivaciones y los significados que tienen los profesores cuando participan en la resignificación del currículo de matemáticas?
El estudio mostró que las motivaciones y los significados que tienen los profesores para participar en la resignificación del currículo de matemáticas se fundamentan en las intersubjetividades; es decir, en aspectos subjetivos que se constituyen en un colectivo con intereses comunes, configurados en una necesidad de formación continuada, en el reconocimiento de aspectos como la empatía y confianza por quienes gestionan la participación, y la autonomía para tomar decisiones. En los significados expresados por los maestros se evidenciaron tensiones, necesidades y concepciones que constituyeron una aproximación a la situación actual e imaginada del currículo de matemáticas de la institución. Con ello, esperamos seguir investigando las maneras de construir una situación dispuesta con la vinculación de estudiantes y familias.