bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment and Prophylaxis of Post-pericardiotomy Syndrome in Cardiac Surgery Patients: A Meta-analysis of Main Trials
Authors: Giacinto Omar , Minati Alessandro , Lusini Mario , Cardetta Francesco , Saltarocchi Sara , D'Abramo Mizar , Miraldi Fabio , Chello Massimo 
Published: June 2021

Abstract
Purpose: Post-pericardiotomy syndrome (PPS) is a common complication of cardiac surgery. This study represents a meta-analysis of trials on treatment and prophylaxis of PPS with colchicine, indomethacin and dexamethasone. The primary endpoint was to investigate the efficacy of these drugs, while the secondary endpoints were the efficacy in reducing hospital readmission, cardiac tamponade, symptom persistence, atrial fibrillation as well as their safety and adverse effects. Methods: Literature research was carried out using PubMed. Inclusion criteria were: studies investigating ≥10 patients with clinically PPS in which colchicine, dexamethasone and indomethacin were compared with placebo. We excluded publications referring only to animal experiments or in vitro experiments, studies on < 10 patients, case reports, congress reports, review articles, editorial letters. Results: Among studies with post-operative colchicine treatment, two of them demonstrated a significant reduction of PPS [95% CI -0,86 (-1,96, 0,25)], [95% CI 0,24 (0,03,0,44)]. In the single pre-surgery colchicine administration study, a reduction of PPS was obtained [95% CI -0,55 (-1,04, -0,06)]. In the indomethacin study, pre-surgery administration was linked to a reduction of PPS [95% CI -2,18 (-4,31, -0,06)]. This result was not reported with pre-operative dexamethasone intake [95% CI 0,50 (0,12, 0,88)]. Conclusion: The overall results show a better outcome when colchicine and indomethacin were administered as primary prophylactic agents in order to prevent PPS and PE. Further studies are needed to confirm these results.
Preoperative Prediction of Lymphovascular Invasion of Colorectal Cancer by Artificial Neural Network
Authors: Wu Dejun , Yang Zhou , Wang Shuyu , Han Hao , Quan Yingjun , Min Zhijun 
Published: June 2021

Abstract
Background: Lymphovascular invasion (LVI) is considered to be important for metastasis of colorectal cancer (CRC). However, there is still no effective method to predict LVI before operation. Our research aimed to construct an artificial neural network (ANN) for the pre-operative prediction of LVI.Methods: We obtained blood indexes and conditions of LVI (confirmed by pathological examination) of 288 cases of CRC patients from a tertiary hospital in China. ANN and logistic regression model were constructed based on randomly chosen 185 cases CRC patients (training group). The remaining 103 cases of CRC patients received tests of ANN and logistic model (validation group). Receiver operating characteristics curve (ROC) and decision curve analysis (DCA) was performed to assess the accuracy of constructed model respectively.Results: In the training group, the area under curve (AUC) of ANN was higher than that of logistic model (0.832 vs 0.692). The ANN correctly predicted 92% cases of LVI, whereas logistic model only predicted 56% cases. Similar results were also tested in the validation model.Conclusions: Our constructed ANN showed higher accuracy compared with a conventional linear model. The ANN based on blood indexes may provide value for pre-operative prediction of LVI.
“Environmental Opportunities for Active Play and Physical Activity Level in Preschoolers: a Multicriteria Analysis.”
Authors: Nobre Juliana Nogueira Pontes , Morais Rosane Luzia Souza , Prat Bernat Viñola , Fernandes Amanda Cristina , Viegas Ângela Alves , Figueiredo Pedro Henrique Scheidt , Costa Henrique Silveira , Camargos Ana Cristina Resende , Alcantara Marcus Alessandro , Mendonça Vanessa Amaral , Lacerda Ana Cristina Rodrigues 
Published: June 2021

Abstract
Background: Active seem to influence the level of physical activity during childhood. However, a gap remains about which environmental opportunities could have a positive impact on the level of physical activity in preschoolers.Objectives: (1) To develop an index to measure the environmental opportunities of free active play for preschoolers of middle-income countries; (2) to check the relationship and contribution of the index to explain objectively the level of physical activity. Methods: A quantitative, cross-sectional, exploratory study with 51 preschool children. The established criteria for the index according to the literature were: (1) Outdoor time on typical days of the week. (2) Outdoor time on a typical weekend day. (3) The presence of internal space and external environment in the child's home that allows playing. (4) Presence of patio with space for games at the school. (5) Presence of a playground with a toy at the school. We applied multi-attribute utility theory for the determination of the multicriteria index. Pearson's correlation analysis and simple linear regression were used to verify the association between the index and the physical activity level. The significance level was set at 5%. Results: The index showed a positive correlation with the level of physical activity, e.g., the average time of moderate to vigorous physical activity (r = 0.408, p <0.003). The univariate linear regression demonstrated that the quality of environmental opportunities for physical activity explained 20% of the preschooler’s classification as active and 16% of the time in moderate to vigorous physical activity (p <0.001). Conclusion: Environmental opportunities for active play have a positive impact on physical activity in preschoolers and should be encouraged in different social segments.
Characteristics and Prognostic Value of Pleural Effusion in Secondary Hemophagocytic Lymphohistiocytosis
Authors: Cheng Wanying , Gao Xin , Yin Guangli , Huang Jiayu , Man Changfeng , Xu Ji , Duan Limin , Tian Tian , Wang Jujuan , Qiu Hongxia 
Published: June 2021

Abstract
Background: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a pathologic immune activation syndrome characterized by immune-mediated multiple organ system damage. Pleural effusion can occur as a specific manifestation of sHLH, however, has rarely been evaluated. This study aimed to describe the clinical characteristics of pleural effusion in sHLH and assesse whether it affects prognosis.Methods: We retrospectively analysed 203 newly diagnosed sHLH patients from July 2015 to July 2019 according to the HLH-2004 protocol. Baseline characteristics, laboratory results, and imaging materials were reviewedResults: Pleural effusion was found in 58.6% of the studied sHLH population, and imaging findings were characterized by minimal amounts and bilaterality. Multivariate analyses showed that sCD25 level and PLT ≤65×109/L were significant risk factors for developing pleural effusion in sHLH. Regarding prognostic value, survival analysis showed a lower survival probability for patients with pleural effusion than for those without pleural effusion (median OS, 90 vs. 164 days, p = 0.028). In the multivariate analysis, pleural effusion was an independent prognostic factor for OS (HR = 2.68; 95% CI 1.18–6.11, p = 0.019). Conclusions: Pleural effusion is frequently found in patients with sHLH and is associated with a higher inflammatory state and worse outcomes.
Wrist Actigraphic Approach in Primary, Secondary and Tertiary Care Based on the Principles of Predictive, Preventive and Personalised (3P) Medicine
Authors: Acker Jens , Golubnitschaja Olga , Büttner-Teleaga Antje , Richter Kneginja 
Published: June 2021

Abstract
Sleep quality and duration as well as activity-rest-cycles at individual level are crucial for maintaining physical and mental health. Although several approaches do exist to monitor these parameters, optimal approaches are still under consideration and technological development.Wrist actigraphy is a non-invasive electro-physical method validated in the field of chronobiology to record movements and to allow for monitoring human activity-rest-cycles. Based on the continuous recording of motor activity and light exposure, actigraphy provides valuable information about the quality and quantity of the sleep-wake rhythm and about the amount of motor activity at day and night that is highly relevant for disease prediction, targeted prevention and personalisation of medical services. Being generally used in the field of sleep medicine, actigraphy demonstrates a great potential to be successfully implemented in primary, secondary and tertiary care, psychiatry, oncology, and intensive care, military and sports medicines as well as epidemiological monitoring of behavioural habits as well as well-being medical support, amongst others. Prediction of disease development and individual outcomesActivity-rest-cycles have been demonstrated to be an important predictor for many diseases including but not restricted to the development of metabolic, psychiatric and malignant pathologies. Moreover, activity-rest-cycles directly impact individual outcomes in corresponding patient cohorts. Targeted preventionData acquired by actigraphy are instrumental for the evidence-based targeted prevention by analysing individualised patient profiles including light exposure, sleep duration and quality, activity-rest-cycles, intensity and structure of motion pattern. Personalised TherapyWrist actigraphic approach is increasingly used in clinical care. Personalised measurements of sedation/agitation rhythms are useful for ICU-patients, for evaluation of motor fatigue in oncologic patients, for an individual enhancement of performance in military and sport medicine. In the framework of personalised therapy intervention, patients can be encouraged to optimise their behavioural habits improving recovery and activity patterns. This opens excellent perspectives for the sleep-inducing medication and stimulants replacement as well as for increasing the role of participatory medicine by visualisation and encouraging favourable behavioural patterns of the individual.
Knee Extensor Rate of Torque Development After Anterior Cruciate Ligament Reconstruction With Hamstring Tendon Autografts in Young Female Athletes
Authors: Suzuki Makoto , Ishida Tomoya , Samukawa Mina , Matsumoto Hisashi , Ito Yu , Aoki Yoshimitsu , Tohyama Harukazu 
Published: June 2021

Abstract
Background: For the measurement of functional deficits after anterior cruciate ligament reconstruction (ACLR) with bone-patellar-tendon bone (BTB) grafts, the knee extensor rate of torque development (RTD) is known as a relevant outcome. However, it remains unclear if the RTD is also a relevant outcome after ACLR with semitendinosus and gracilis tendon (STG) autografts. The purpose of the present study was to compare the limb symmetry index (LSI) of the RTD of the quadriceps with that of the peak torque after ACLR using STG autografts and to investigate the relationship between the self-reported functional outcome and the LSI of the torque parameters.Methods: Eighteen young female athletes after ACLR with STG grafts (age: 16.8 ± 1.3 years; time after surgery: 8.6 ± 0.8 months). The participants had undergone three maximal voluntary isometric quadriceps tests using an isokinetic dynamometer. Using the torque-time curves, the peak torque, RTD100 (0 to 100 ms) and RTD200 (100 to 200 ms) were determined. The International Knee Documentation Committee subjective knee evaluation form (IKDC-SKF) was used to assess self-reported knee function. Comparisons of the LSI of the peak torque and RTD were performed by analysis of variance (ANOVA) with Bonferroni’s correction as a post-hoc test. The Pearson correlation coefficient was used to examine the associations of the IKDC-SKF score with the LSI of the RTD and peak torque.Results: The LSI of the peak torque and RTD200 was significantly lower than that of the RTD100 (peak torque vs RTD100: P = 0.017; RTD200 vs RTD100: P = 0.015). The LSI of the peak torque was positively correlated with the IKDC-SKF score (R = 0.621; P = 0.006).Conclusions: The peak torque and RTD200 were more sensitive for detecting inter-limb differences in quadriceps function than RTD100. The IKDC-SKF score was correlated with the LSI of the quadriceps peak torque but not with that of the RTD. The peak torque of the quadriceps was considered an appropriate screening for functional recovery after ACLR with STG grafts.
Subjective Well-being in Non-obese Individuals Depends Strongly on Body Composition
Authors: Chlabicz Małgorzata , Paniczko Marlena , Jamiołkowski Jacek , Sowa Paweł , Łapińska Magda , Raczkowski Andrzej , Łaguna Wojciech , Moniuszko-Malinowska Anna M. , Waszkiewicz Napoleon , Kowalska Irina , Kamiński Karol Adam 
Published: June 2021

Abstract
While obesity has been correlated with welfare in the general population, there is not much data on the influence of body composition on welfare among the non-obese adult individuals. A total of 726 non-obese individuals from general population were analyzed. The mean age was 46.8±15.4 years and 42.1% of participants were male. The mean value for Satisfaction with Life Scale (SWLS) was 23.09±5.43, for Euro Quality of Life Visual Analogue Scale (EQ-VAS) was 78.0±14.5, and for Beck Depression Inventory (BDI) was 6.7±6.6. On SWLS the waist-hip ratio had a negative impact even after adjustment for age, gender and concomitant diseases. EQ-VAS was inversely associated with android fat distribution and directly associated with muscle mass. BDI value was inversely associated with lower muscle mass, especially of the lower limbs. The well-being of women was mainly associated with the distribution of adipose tissue and less with the distribution of muscle tissue - abdominal fat distribution has a particularly negative impact on well-being among women. In contrast, men's well-being depends more on muscle mass and to a lesser extent on the distribution of fat tissue - a positive significant effect has lean mass and a circumference of thigh below gluteal fold.
Complete Genome Sequence of GII.9 Norovirus
Authors: Zhang Zilong , Liu Danlei , Zhang Zilei , Tian Peng , Wu Qingping , Wang Dapeng , Tian Zhengan 
Published: June 2021

Abstract
Norovirus is recognized as one of the leading causes of acute gastroenteritis outbreaks. Genotype GII.9 was first detected in Norfolk, USA in 1997. However, the complete genome sequence of this genotype was not established yet. In this study, a complete genome sequence of a GII.9[P7] norovirus, marked as SCD1878, from a patient was established using a high-throughput sequencing and rapid amplification of cDNA ends (RACE) technology. The complete genome sequence of SCD1878_GII.9P7 was 7544 nucleotides (nts) in length with a 3’ poly (A) tail, including three open reading frames. Homology analysis indicated that SCD1878_GII.9P7 shares 92.1%-92.3% identity with GII.P7 (AB258331 and AB039777) and 96.7%-97.4% identity with GII.9 (AY038599 and DQ379715) sequences. The results suggested that SCD1878 is a member of GII.P7 for P genotypes and GII.9 for genotypes. The viral sequence filled the gap in the whole genome level of the GII.9 genotype.
Carbon Dioxide Snow Cleaning of Paper
Authors: Maskova Ludmila , Smolik Jiri , Vavrova Petra , Neoralova Jitka , Souckova Magda , Novotna Dana , Jandova Vera , Ondracek Jakub , Ondrackova Lucie , Krizova Tereza , Kocova Katerina , Stanovsky Petr 
Published: June 2021

Abstract
Cleaning of particles from smooth and rough paper surfaces was investigated using a high-speed CO2 snow jet. The measurements included characterization of the jet properties, determination of the cleaning efficiency, and evaluation of the possible adverse effects. The method was compared with the nitrogen jet cleaning and the dry cleaning by commercial materials. The results showed that the CO2 snow jet is able to effectively remove particles from the paper surface and did not cause any observable degradation. The CO2 snow jet cleaning compared with the mechanical dry cleaning showed similar effectiveness without any adverse effects on the paper surface. It was proved that the CO2 snow technique is a suitable method for cleaning of common types of paper materials.
Phytate and Microbial Suspension Amendments Increased Soybean Growth and Shifted Microbial Community Structure
Authors: Ahmed Bulbul , Floc'h Jean-Baptiste , Lahrache Zakaria , Hijri Mohamed 
Published: June 2021

Abstract

Phytate represents an organic pool of phosphorus in soil that require hydrolysis by phytase enzymes produced by microorganisms prior to its bioavailability by plants. We hypothesize that in a greenhouse trail on soybean plants inoculated or non-inoculated with a microbial suspension made from an age-old maple forest’s undisturbed soil mineralize phytate. MiSeq Amplicon sequencing targeting bacterial 16S rRNA gene and fungal ITS was performed to assess microbial community changes following treatments. Our results showed that soybean nodulation and shoot dry weight biomass increased when phytate was applied to the nutrient-poor substrate mixture. Bacterial and fungal diversities of the root and rhizosphere biotopes were relatively resilient following inoculation by microbial suspension; however, bacterial community structure was significantly influenced. Interestingly, four arbuscular mycorrhizal fungi (AMF) were identified as indicator species, including Glomus sp., Claroideoglomus etunicatum, Funneliformis mosseae and an unidentified AMF taxon. We also observed that an ericoid mycorrhizal taxon Sebacina sp. and three Trichoderma spp. were among indicator species. Non-pathogenic Planctobacteria members highly dominated the bacterial community as core and hub taxa for over 80% of all bacterial datasets in root and rhizosphere biotopes. Overall, our study documented that inoculation with a microbial suspension and phytate amendment improved soybean plant growth.
Biopolymeric superabsorbent hydrogels: impact on soil moisture release pattern, crop and water productivity of soybean–wheat under different irrigation regimes in Indo-Gangetic plains of India
Authors: GA Rajanna , Manna Suman , Singh Anupama , Babu Subhash , Singh VK , Dass Anchal , Chakraborty Debashis , Patanjali Neeraj , Chopra Indu , Banerjee Tirthankar , Kumar Anil , Khandelwal Ashish , Parmar Balraj S 
Published: June 2021

Abstract
Environmental crises, declining factor productivity, and shrinking natural resource threatened global agricultural sustainability. The task is much more daunting in the Indo-Gangetic northern plains of India, where depletion of the underground water table and erratic rains due to the changing climate pose a major challenge to agriculture. To address these challenges a field investigation was carried out during 2016–18 to test the efficacy of biopolymeric superabsorbent hydrogels namely Pusa Hydrogel (P-hydrogel: a semi-synthetic cellulose derivative-based product) and kaolin derivative of Pusa Hydrogel (K-hydrogel: semi-synthetic cellulose derivative) to assess their effect on crop and water productivity, soil moisture, root dynamics, and economics of soybean (Glycine max L.)–wheat (Triticum aestivum L.) system under three irrigation regimes namely full irrigation, limited irrigation and rainfed. The results revealed that the full irrigation along with P-hydrogel led to enhanced grain yield, biomass yield, and water productivity (WP) of soybean (1.61–10.5%, 2.2–9.5%, and 2.15–21.8%, respectively) and wheat (11.1–18.3%, 12–54% and 11.1–13.1%, respectively) over control plots. The best performance of P-hydrogel was observed under full irrigation compared to K-hydrogel (both at 2.5 and 5.0 kg− 1) and control. Plots treated with P-hydrogel retained 3.0–5.0% higher soil moisture compared to no-hydrogel plots, while K-hydrogel treated plots held the lower moisture (4.0–6.0%) than the control. In terms of profitability, full irrigation along with P-hydrogel plots registered 12.97% higher economic returns over control. The results suggested that full irrigation along with P hydrogels (2.5 kg ha− 1) is a viable option for sustainable production of soybean-wheat systems in the Indo-Gangetic plains of India and other similar eco-regions of the world.
Enhancing Osseointegration and Mitigating Bacterial Biofilms on Medical-Grade Titanium with Chitosan-Conjugated Liquid-Infused Coatings
Authors: Zhang Yuxi , Villegas Martin , Badv Maryam , Alonso-Cantu Claudia , Wilson David , Hosseinidoust Zeinab , Didar Tohid F. 
Published: June 2021

Abstract
Titanium alloys, in particular, medical-grade Ti-6Al-4V is heavily used in orthopaedic applications due to its high moduli, strength, and biocompatibility. Implant infection can result in biofilm formation and failure of prosthetics. The formation of a biofilm on implants protect bacteria from antibiotics and the immune response, resulting in the propagation of the infection and ultimately result in device failure. Recently, slippery liquid-infused surfaces (LIS) have been investigated for their stable liquid interface, which provide excellent repellent properties to suppress biofilm formation. One of the current limitations of LIS coatings lies in the indistinctive repellency of bone cells in orthopaedic applications, therefore causing poor integration between tissue and implant. Here, we report a chitosan impregnated LIS coating that facilitates cell adhesion and osseointegration while preventing biofilm formation. Our results indicate that chitosan-conjugated LIS increased cell adhesion of osteoblast-like SaOS-2 cells and significantly promoted proliferation compared to conventional titanium liquid-infused surfaces. Furthermore, the chitosan conjugated LIS significantly reduced biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA) when compared to untreated and chitosan-coated titanium. Our engineered coating can be easily modified with other biopolymers or capture molecules to be applied to other biomaterials where both tissue integration and biofilm prevention is needed.
A Chinese Survey of Current Practice Patterns of Preoperative Bowel Preparation in Colorectal Surgery
Authors: Yu Hong , Xu Li , Liu Shuhao , Yin Songcheng , Hong Chunhong , Yang Shaohua , Chen Jingyao , Li Jianfeng , Zhang Changhua 
Published: June 2021

Abstract
Background

Bowel preparation has long been considered as the standard preoperative management for colorectal surgery. However, there are still controversies about bowel preparation and the importance of bowel preparation gradually declined. The purpose of this study is to describe the current attitudes and practice patterns of preoperative bowel preparation among Chinese surgeons.
Methods

An online 11-question anonymous survey was randomly assigned to Chinese surgeons. The questionnaire sought information on each surgeon’s current practice of preoperative bowel preparation.
Results

384 Chinese surgeons from 26 provincial administrative regions took part in this survey. The most common reason for choosing bowel preparation was preventing surgical site infection (SSI). Meanwhile, 74% Chinese surgeons believed bowel preparation could avoid anastomotic leakage. Only 34% thought that bowel preparation was considered to reduce risk of postoperative bleeding. In terms of bowel preparation methods, 57% Chinese surgeons preferred to choose laxatives alone. Regarding the choices of agents, Chinese surgeons were more likely to choose polyethylene glycol-electrolyte lavage solution (PEG-ELS).
Conclusions

Surgeons choose bowel preparation mostly to avoid SSI and anastomotic leakage, and they prefer using laxatives alone. Our study shows that surgeons do not have clear guidelines that can govern their clinical practice and there are still controversies about bowel preparation. Further study is required to provide strong evidences to inform clinical and policy decisions.