bluuebunny/crossref_metadata_2025_split huggingface dataset:
Premature ageing of lung alveoli and bone marrow cells from Terc deficient mice with different telomere lengths
Authors: Guerrero-López Rosa , Manguán-García Cristina , Carrascoso-Rubio Carlos , Lozano M. Luz , Toldos-Torres Marta , García-Castro Laura , Sánchez-Dominguez Rebeca , Alberquilla Omaira , Sánchez-Pérez Isabel , Molina-Molina Maria , Bueren Juan A. , Guenechea Guillermo , Perona Rosario , Sastre Leandro 
Published: February 2025

Abstract
Telomeres are terminal protective chromosome structures. Genetic variants in genes coding for proteins required for telomere maintenance cause rare, life-threatening Telomere Biology Disorders (TBDs) such as dyskeratosis congenita, aplastic anemia or pulmonary fibrosis. The more frequently used mice strains have telomeres much longer than the human ones which question their use as in vivo models for TBDs. One mice model with shorter telomeres based on the CAST/EiJ mouse strain carrying a mutation in the Terc gene, coding for the telomerase RNA component, has been studied in comparison with C57BL/6J mice, carrying the same mutation and long telomeres. The possible alterations produced in lungs and the haematopoietic system, frequently affected in TBD patients, were determined at different ages of the mice. Homozygous mutant mice presented a very shortened life span, more notorious in the short-telomeres CAST/EiJ strain. The lungs of mutant mice presented a transitory increase in fibrosis and a significant decrease in the relative amount of the alveolar epithelial type 2 cells from six months of age. This decrease was larger in mutant homozygous animals but was also observed in heterozygous animals. On the contrary the expression of the senescence-related protein P21 increased from six months of age in mutant mice of both strains. The analysis of the haematopoietic system indicated a decrease in the number of megakaryocyte-erythroid progenitors in homozygous mutants and an increase in the clonogenic potential of bone marrow and LSK cells. Bone marrow cells from homozygous mutant animals presented decreasing in vitro expansion capacity. The alterations observed are compatible with precocious ageing of lung alveolar cells and the bone marrow cells that correlate with the alterations observed in TBD patients. The alterations seem to be more related to the genotype of the animals that to the basal telomere length of the strains although they are more pronounced in the short-telomere CAST/EiJ-derived strain than in C57BL/6J animals. Therefore, both animal models, at ages over 6–8 months, could represent valuable and convenient models for the study of TBDs and for the assay of new therapeutic products.
Identification and validation of PANoptosis-related LncRNAs prognosis system in hepatocellular carcinoma
Authors: Shu Qi , Zhu Junfeng , Mo Jiaping , Wei Xiaoyan , Zhu Zhenjie , Chen Xiaojuan , He Fugen , Zhong Like 
Published: February 2025

Abstract
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies in the world. Due to the limited effectiveness of current drug treatments, further research on HCC is necessary. PANoptosis is defined as an inflammatory RCD whose main features combine pyroptosis, apoptosis and necroptosis which cannot be explained by any of these three RCDs alone. In HCC, risk stratification based on PANoptosis-associated lncRNAs has clinical application potential. In this study, we explored HCC related PANoptosis-related lncRNAs (PRLs) by analyzing significantly differentially expressed genes in HCC. HCC-associated PRL scores were established by WGCNA, LASSO analysis and multivariate Cox assessment. Subsequently, we verified the prognostic analysis ability of PRL score for HCC patients, and on this basis established a prognostic risk assessment model for HCC and verified its reliability. The relationship between PRL score and immune infiltration as well as drug sensitivity was further analyzed to evaluate the clinical reference value of this model. Western blot analysis and PCR further verified the reliability of bioinformatics results. The observed suppression of HCC progression and invasiveness following selected PRL knockdown further validated the reliability of our bioinformatics analysis results. Our results provide new evidence for the role of PANoptosis-associated lncRNAs in HCC.
An evaluation of speech therapy care in the surrounding area of an interdisciplinary cleft lip and palate tertiary care center
Authors: Schaffrath Katharina , Ooms Mark , Seidel Simone , Hölzle Frank , Modabber Ali 
Published: February 2025

Abstract
The anatomical deformation in cleft patients requires speech therapy to support cleft patients as best as possible. The aim of this study was to evaluate the standard of knowledge of therapists concerning clefts. Furthermore, the study aimed to determine whether there was a difference between therapists with and without treatment experience in cleft patients as well as among therapists with more or less years of general professional experience. We developed a questionnaire about different areas of speech therapy: “General,” “Speech therapy,” “Development opportunities and influences,” and “Interdisciplinary collaboration.” For a total of 50 questions, we used single-, multiple-choice questions and the visual analog scale (VAS). Speech therapists with experience in treating cleft patients (n = 43) felt more confident regarding their knowledge and abilities than therapists without experience (n = 61), especially concerning nonspecialist disciplines and cleft specifications. No difference was found in therapy duration, indications, influences, and potential for development. Professional experience (years) and cleft experience correlate; with more knowledge in the group with more than 8 years of experience. Cleft centers remain first choice for patients’ care thanks to the higher number of patients, daily treatment routine, the direct contact among examiners, and a common treatment concept.
Short internal open reading frames repress the translation of N-terminally truncated proteoforms
Authors: Fettig Raphael , Gonda Zita , Walter Niklas , Sallmann Paul , Thanisch Christiane , Winter Markus , Bauer Susanne , Zhang Lei , Linden Greta , Litfin Margarethe , Khamanaeva Marina , Storm Sarah , Münzing Christina , Etard Christelle , Armant Olivier , Vázquez Olalla , Kassel Olivier 
Published: February 2025

Abstract
Internal translation initiation sites, as revealed by ribosome profiling experiments can potentially drive the translation of many N-terminally truncated proteoforms. We report that internal short open reading frame (sORF) within coding sequences regulate their translation. nTRIP6 represents a short nuclear proteoform of the cytoplasmic protein TRIP6. We have previously reported that nTRIP6 regulates the dynamics of skeletal muscle progenitor differentiation. Here we show that nTRIP6 is generated by translation initiation at an internal AUG after leaky scanning at the canonical TRIP6 AUG. The translation of nTRIP6 is repressed by an internal sORF immediately upstream of the nTRIP6 AUG. Consistent with this representing a more general regulatory feature, we have identified other internal sORFs which repress the translation of N-terminally truncated proteoforms. In an in vitro model of myogenic differentiation, the expression of nTRIP6 is transiently upregulated through a mechanistic Target of Rapamycin Complex 1-dependent increase in translation initiation at the internal AUG. Thus, the translation of N-terminally truncated proteoforms can be regulated independently of the canonical ORF.
N-doped graphdiyne derivative for highly selective and ultrasensitive NH3 sensing at room temperature
Authors: Ma Dong-Feng , Liu Hai-Qi , Zhang Xi-Yu , Jia Ya-Nan , Zhang Xue , Niu Fang , Zhang Kai-Feng , Zhao Yong-Qing 
Published: February 2025

N-doped graphdiyne derivative (N-GDYD) showed excellent sensing ability to ppb level NH3 and alkyne bond and N atoms in triazine ring synergistically enhanced its sensing ability.
Unmanned aerial vehicles versus smart grids
Authors: Pengfei Zhao Alexis , Li Shuangqi , Huo Da , Alhazmi Mohannad 
Published: February 2025

AbstractThe increasing threat of unmanned aerial vehicles (UAVs) to smart grid infrastructures poses critical challenges to energy systems security. This study examines smart grid vulnerabilities to UAV‐based attacks and proposes a novel optimisation framework to enhance grid resilience. Employing a multi‐objective optimisation approach using the Non‐dominated Sorting Genetic Algorithm III (NSGA‐III) and a game‐theoretic Stackelberg model, the research captures the strategic interplay between UAV operators and grid defenders. Key contributions include the development of a multi‐objective optimisation framework, integration of adversarial game theory, incorporation of dynamic environmental conditions, and generation of Pareto‐optimal solutions for strategic defence planning. This research makes four pivotal contributions: (a) the design of a comprehensive multi‐objective optimisation framework tailored for UAV strike optimisation, (b) the integration of game‐theoretic principles to model adversarial behaviours, (c) the inclusion of dynamic environmental factors to improve solution robustness, and (d) the application of NSGA‐III to generate trade‐off solutions, equipping decision‐makers with diverse strategies to enhance grid resilience. By addressing an urgent and timely challenge, this work offers practical guidance for fortifying smart grid infrastructures against emerging UAV threats in increasingly complex operational environments.
Loncastuximab-Tesirin plus Rituximab als neue Option?
Authors: Kretzschmar Alexander 
Published: February 2025

ZusammenfassungDie Ergebnisse einer pivotalen Phase-II-Studie zeigen, dass das Antikörper-Wirkstoff-Konjugat Loncastuximab-Tesirin plus Rituximab das progressionsfreie-(PFS) bzw. Gesamtüberleben (OS) auch bei schwer behandelbaren Patient*innen mit rezidivierten bzw. refraktären follikulären Lymphomen (FL) und hoher Krankheitslast verbessert.
HYBRID – Vorhersagewert der F-18-FDG-PET/CT für Programmed-deathligand-1-Expression in NSCLC
Authors: Zippel Sarah C. 
Published: February 2025

ZusammenfassungMit gegen Programmed-cell-deathProtein (PD-1) und Programmeddeath-ligand-1 (PD-L1) gerichteten monoklonalen Antikörpern steht für nicht kleinzellige Lungenkarzinome (NSCLC) mit Ausprägung einer entsprechenden Expression eine äußerst wirkungsvolle Therapie zur Verfügung. Die Selektion der Patienten, die von einer solchen Therapie profitieren und gegebenenfalls keine zusätzliche Chemotherapie benötigen, ist aber eine Herausforderung.
A solid-state high voltage pulse power supply with three output voltages
Authors: Pan Zilong , Cheng Xinbing , Chen Rong , Zhang Hanwen , Zhang Renjie , Yang Jianhua , Qian Baoliang 
Published: February 2025

A solid-state high voltage pulse power supply with three synchronous output voltages is designed and constructed in this paper. The pulse power supply consists of a fractional-turn ratio saturable pulse transformer and three six-stage Marx generators. The FRSPT not only works as step-up pulse transformers but also as magnetic switches of the Marx generators. All magnetic switches are developed based on two communal cores to achieve a perfect multiple-pulse synchronization effect. The experimental results show that the three output voltages have an amplitude of about 168 kV and a rising time of about 102.6 ns with a 2 MΩ dummy load. The pulse power supply can operate stably at frequencies of 1, 5, 10, and 15 Hz with the synchronization jitters less than 1.5 ns.
Conformational fluxionality of long-chain alkene clusters in the gas phase evidenced from a combined experimental and theoretical approach
Authors: Lewin C. Smith , Herbinet O. , Arnoux P. , Battin-Leclerc F. , Garcia G. A. , Nahon L. , Tran L. S. , Vanhove G. , Al Mogren M. Mogren , Hochlaf M. , Calvo F. , Bourgalais J. 
Published: February 2025

Clusters bound by weak, non-covalent forces, such as van der Waals interactions and hydrogen bonds, are ubiquitous in dilute media ranging from aerosols to molecular fluids and biological structures, their interest being not only fundamental as in astrochemistry but also more applied as in organic electronics. Neutral clusters of up to six 1-hexene molecules produced by supersonic expansion of a gas mixture were ionized, mass selected, and spectroscopically characterized using synchrotron-based VUV photoelectron photoion coincidence technique. Ionization energies inferred from these measurements show decreasing trends as the cluster size increases, by about 0.5 eV over the range of 1–6 molecules. Dedicated theoretical DFT-based calculations were performed to unravel the possible structures of these clusters and determine their vertical and adiabatic ionization energies. Our computational search for stable structures considered the possible chirality effects associated with most conformers of the monomer having enantiomers, in an approach with a broad structural sampling employing classical force fields followed by systematic re-optimization using an efficient quantum chemical method. Vertical and adiabatic ionization energies obtained using wavefunction-based methods exhibit significant dispersion due to conformational flexibility already in the monomer, but these effects are magnified in clusters due to their fluxionality at the experimental temperature of about 130 K. Overall, the trends obtained for the calculated vertical ionization energies agree well with the measured data and suggest that possible chiral recognition effects that could stabilize specific structures are likely to be hampered under the present experimental conditions.
Emotional language within influencer marketing on YouTube
Authors: Pelttari Sanna 
Published: February 2025

Abstract
This case study of twelve videos of Spanish YouTubers explores emotional language within influencer marketing.
Special consideration is given to whether hedonic values were prevalent in the emotionally charged evaluations without neglecting
the utilitarian values involved. The analysis of this interdisciplinary study reveals that most of the evaluations, the majority
of which were directed toward feeling products, were generally positive. Expressions were categorized into different overlapping
reasons, reflecting the co-occurrence of both hedonic and utilitarian rational values. Nonetheless, a general correlation can be
established between hedonic values and feeling products, and between utilitarian values and thinking products. Furthermore, the
YouTubers consistently employed the same linguistic and lexical patterns throughout the observed data, giving the impression of a
rather spontaneous way of speaking in these videos. The videos were characterized by a certain amateurism on a discursive level,
but with some features of professionalization particularly in the case of thinking products.
3D-printed microneedle arrays for real-time interstitial fluid glucose monitoring
Authors: Zhou Qingdi , Wang Yangjun , Pan Mingqiang , Wang Chunju , Chen Liguo 
Published: February 2025

Abstract
Efficient, accurate, and real-time blood glucose monitoring is crucial for diabetes management. Using interstitial fluid (ISF) instead of blood for monitoring is a key focus. However, microneedle-based in-situ methods face challenges in comfort and miniaturization. This study presents a novel wearable patch for ISF glucose monitoring. The patch features a miniature square microneedle array (MNA) connected to the substrate via microstructure, ensuring strong fixation and easy replacement. The MNA is 3D-printed, offering personalization, efficiency, low cost and biocompatibility. Through the design of the microneedle arrangement on the array, an innovative circular array microneedle configuration is utilized to reduce insertion difficulty and enhance long-term wear comfort by reducing issues related to skin elasticity. Its surface is modified with a bonding, conductive, and functionalized layer for accurate glucose monitoring after insertion. Experimental results show the sensor’s high sensitivity and selectivity for real-time ISF glucose monitoring, suitable for both healthy individuals and diabetics. The device is painless, compact, flexible, low-cost, and comfortable, with replaceable electrodes, making it promising for practical diabetes management.
Monocular Visual Odometry in Dynamic Environments by utilizing Motion Segmentation and Attention Mechanism
Authors: Chen Shuo , Lu Lixin , Chen Dongxing , Chen Dongdong , Kong Dongdong 
Published: February 2025

Abstract
Learning-based visual odometry (VO), that estimates frame-to-frame (F2F) translation and rotation in end-to-end network, has attracted much attention in recent years. However, existing methods perform poorly in complex environments, especially when there are moving objects in the scene. To solve the above issues, a novel monocular visual odometry is proposed based on motion segmentation and attention mechanism under dynamic environments. Firstly, semantic information and optical flow residuals are adopted for motion segmentation through iterative optimization, so as to eliminate the influence of dynamic objects. Secondly, a parallel attention mechanism module is used for extracting the most relevant features for pose estimation. Two types of experiment (Odometry dataset and Tracking dataset) based on Karlsruhe Institute of technology and Toyota Technological Institute (KITTI) are carried out to show the effectiveness of the proposed method. Experimental results show that the accuracy of pose estimation is greatly improved by adding motion segmentation and attention mechanism. Moreover, the comparison results show that the proposed method performs comparably to geometry-based techniques and outperforms other learning-based approaches. This paper lays the foundation for accurate pose estimation in dynamic environments.&#xD;
Study on diaphragm pump fault diagnosis and data correction techniques in online oil chromatography based on multilayer perceptrons
Authors: Yajun Jia , Jicheng Zhang , Junjie Jiang , Zhijian Jin 
Published: February 2025

Abstract
The diaphragm pump is a vital component in the online oil chromatography device for oil–gas separation, and its performance plays a crucial role in determining the accuracy and reliability of gas detection. However, over time, due to continuous use and external environmental factors, the performance of the diaphragm pump gradually declines. This degradation results in an insufficient vacuum during the degassing process, which adversely affects the accuracy of gas detection. To tackle this issue, this paper combines simulation and experimental approaches to thoroughly investigate the causes of diaphragm pump performance degradation and its theoretical lifespan. It also examines the impact of insufficient vacuum on the detection accuracy of various gases. In addition, by analyzing the current variation patterns of the diaphragm pump during operation, a multilayer perceptron (MLP) algorithm is applied to create a fault diagnosis and data error correction model for the diaphragm pump. Experimental results demonstrate that when the vacuum level surpasses 70%, the MLP model is capable of keeping the correction error for seven types of fault gases below 10%, significantly enhancing detection accuracy. This study offers valuable insights for the reliability assessment and performance optimization of online oil chromatography devices, helping to reduce maintenance costs and improve the safe operation of power transformers.
Including the vacuum energy in stellarator coil design
Authors: Guinchard S , Hudson S R , Paul E J 
Published: February 2025

Abstract
Being three-dimensional, stellarators have the advantage that plasma currents are not essential for creating rotational-transform; however, the external current-carrying coils in stellarators can have strong geometrical shaping, which can complicate the construction. Reducing the inter-coil electromagnetic forces acting on strongly shaped 3D coils and the stress on the support structure while preserving the favorable properties of the magnetic field is a design challenge. In this work, we recognize that the inter-coil forces are the gradient of the vacuum magnetic energy. We introduce an objective functional built on the usual quadratic flux on a prescribed target surface together with a weighed penalty on the vacuum energy. The Euler–Lagrange equation for stationary states is derived, and numerical illustrations are computed using a modern stellarator optimization framework. A study of the effect of the energy functional on the inter-coil forces is conducted and the energy is shown to be a promising quantity in producing coils with low forces.
Two-dimensional particle-in-cell simulation to investigate electron heating mechanism in intermediate-pressure RF hollow cathode discharges
Authors: Park Heesung , Lee Hae June 
Published: February 2025

Abstract
While electron heating in a low-pressure DC hollow discharge occurs by the electron pendulum effect in the hole, the heating mechanism of RF hollow discharges at high collisionality is not fully elucidated yet. Phase-resolved analysis with a two-dimensional particle-in-cell simulation enables the investigation of how the electron heating and density distribution changes by the electrode shape, bias voltage, secondary electron emission (SEE), and gas pressure in the RF hollow cathode discharge. Multiple density peak occurs depending on the energy relaxation mean free path of electrons, and anomalous electron heating occurs between the density peaks. Spatio-temporal analysis of electron heating at various locations is provided for DC bias and SEE variations.
Boosting critical current density in Bi-2212/Ag round wires by precise tuning 14:24AEC phase
Authors: Jin L H , Li C S , Liu G Q , Xu X Y , Jiao G F , Zhi L , Hao Q B , Feng J Q , Li J F , Zhang S N , Zhang P X 
Published: February 2025

Abstract
Bi2Sr2CaCu2O
x
(Bi-2212)/Ag round wires prepared by the powder-in-tube method is a promising high-temperature superconductor for ultra-high field applications. The current capacity of Bi-2212/Ag wires is negatively affected by the impurity phase of Bi2Sr2CuO
x
(Bi-2201). In this work, a novel precursor powder fabrication technique was developed to eliminate the presence of large residual Bi-2201 grains and to enhance the critical current density (J
c) of Bi-2212/Ag wires. Bi-2212 incorporating (Sr, Ca)14Cu24O
y
(14:24AEC) precursor powders was prepared using a combination of ultrasonic spray pyrolysis and calcination processes. The influence of the 14:24AEC phase on the phase, microstructure, melting behavior and superconducting properties of Bi-2212/Ag wires was systematically investigated. During the overpressure heat treatment, the addition of 14:24AEC into the wire promoted melting, effectively reducing the formation of large Bi-2201 grains. Moreover, the formation of narrow Bi-2201/Bi-2212 intergrowth and stacking faults were introduced into the Bi-2212 matrix. The Bi-2212/Ag wire with added 2 wt% 14:24AEC exhibited a maximum J
c of 4670 A mm−2 at 4.2 K and 12 T. Therefore, precise tuning of the alkaline earth cuprate composition in precursor powders could be a valid approach for improving the current capacity of Bi-2212/Ag multi-filamentary wires.