bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiallodynic effect of propoxazepam at monoiodoacetate-induced osteoarthritis in rats
Authors: Golovenko M.Ya. , Valivodz I.P. , Reder A.S. , Larionov V.B. 
Published: January 2025

Background. Osteoarthritis (OA) is a chronic degenerative joint disease that affects around 654 million persons aged ≥ 40 years worldwide; it most commonly affects joints of knees, hips, hands, and feet in people and is considered to be one of the most expensive chronic conditions to treat. The purpose of this study was to assess the antiallodynic effects of orally administered propoxazepam in the monoiodoacetate-induced knee osteoarthritis (MIA) model in rats. Materials and methods. Unilateral OA was induced by an intra-articular injection of MIA (2 mg/50 μl) into the tibio-femoral joint cavity of the right hindpaw of the rat at the beginning of the experiment (on D0) under gas anesthesia (3.5% isoflurane/3 L/min). Tactile allodynia was assessed using the electronic Von Frey test 2 hours after propoxazepam administration. To determine the statistical effect of the test substance and the reference substance, data were analyzed by a parametrical t-Student test for dependent sets. The significance was estimated at levels p ≤ 0.05 and p ≤ 0.01. Results. Our findings demonstrated that at 10 and 20 mg/kg, propoxazepam induced a significant increase in the paw withdrawal threshold as compared to the vehicle-treated group (+32 and +46 %), highlighting an antiallodynic efficacy. The mean effective dose (ED50) of propoxazepam in this model using the probit-method conditions was estimated as 33.8 mg/kg on rats. Conclusions. Propoxazepam demonstrates significant antiallodynic effects in a rat model of OA (p ≤ 0.05 for doses 2 and 4 mg/kg, p ≤ 0.01 for doses 10 and 20 mg/kg), suggesting its potential as a therapeutic option for managing pain associated with this condition. However, further studies are required to explore the long-term efficacy and safety profile of propoxazepam in chronic pain management related to OA.
PROFESSIONALISM COMPETENCY OF PUBLIC ISLAMIC SENIOR HIGH SCHOOL (MAN) TEACHERS IN WELCOMING THE ERA OF THE INDUSTRIAL REVOLUTION 4.0 IN ACEH
Authors: Fithriani Fithriani , Darmiah Darmiah , Walidin AK Warul , Syabuddin Syabuddin , Sulaiman Sulaiman 
Published: January 2025

This study aimed to determine the professional competence of teachers of the Public Islamic Senior High School ((known as Madrasah Aliyah Negeri or MAN) in welcoming the industrial revolution 4.0 era in Aceh. This qualitative research involve three principals and 60 teachers from three schools in Aceh who were selected purposively. Data analysis was carried out using a descriptive approach. The results showed that the professionalism of MAN teachers in Aceh in welcoming the industrial 4.0 era was good. It was indicated by teachers' skills in planning learning implementation plans, utilizing web-based media, using various teaching methods, using a student-centered approach, using cooperative learning models, and developing learning interactions. The professionalism of MAN teachers in Aceh has implications for improving the quality of learning, indicated by an increase in learning motivation and an increase in student participation in learning. Teachers' strategy in developing teacher professionalism in welcoming the industrial 4.0 era was carried out by pursuing a master's degree and a teacher professional development training program.
Prescribing Trends of Glucose-Lowering Medications Near End of Life Among Adults With Type 2 Diabetes: A Cohort Study
Authors: Kutz Alexander , Kim Dae Hyun , Liu Jun , Munshi Medha N. , Patorno Elisabetta 
Published: January 2025

OBJECTIVE
To assess prescribing trends of glucose-lowering medications in the last year of life among older adults with type 2 diabetes (T2D) and explore whether frailty is associated with differential prescribing.

RESEARCH DESIGN AND METHODS
In this observational cohort study of Medicare beneficiaries aged ≥67 years (2015–2019) with T2D, we assessed temporal trends in prescribing a glucose-lowering medication, stratified by frailty. The main outcome included glucose-lowering medication fills within 1 year of death.

RESULTS
Among 975,407 community-dwelling Medicare beneficiaries with T2D, the use of glucose-lowering medications within 1 year of death slightly increased from 71.4% during the first 6-month period in 2015 to 72.9% (standardized mean difference [SMD] −0.03) during the second 6-month period in 2019. The most pronounced increase in use was observed for metformin (40.7% to 46.5%, SMD −0.12), whereas the largest decrease was observed for sulfonylureas (37.0% to 31.8%, SMD 0.11). Overall glucose-lowering medication use decreased from 66.1% in the 9 to 12 months before death to 60.8% in the last 4 months of life (SMD 0.11; P &lt; 0.01), driven by reduced noninsulin medication use. The use of short-acting and long-acting insulin both increased near death, with frailer individuals more likely to receive insulin. Sodium–glucose cotransporter-2 inhibitors and glucagon-like peptide 1 receptor agonists, although less common, became more frequent in more recent years.

CONCLUSIONS
The use of glucose-lowering medications declined in the last year of life, mainly due to reduced noninsulin use. Insulin use increased near death, particularly among frailer individuals, highlighting the need for careful end-of-life management.
Numerical Model of Formation of Ejecta Faculae on Ceres
Authors: Czechowski Leszek 
Published: January 2025

Abstract
On the dwarf planet Ceres, there are bright spots known as faculae. Four types of faculae are distinguished: (a) floor faculae, (b) faculae on Ahuna Mons, (c) rim/wall faculae found on craters' rims or walls, and (d) ejecta faculae in the form of bright ejecta blankets. Our investigation on the interaction of the hypothesized subsurface originated jet of gas and the granular material indicated that floor faculae (a) could be a result of separation of fine bright component of regolith. Here, we consider the hypothesis that the ejecta faculae (d) may be the result of separation of grains due to explosive gas expansion during the formation of the impact crater. We consider the axisymmetric gas motion above the surface of Ceres. We transform our system of equations into a dimensionless form. Our numerical model indicates that the separation effect is strong enough to separate the grains (according to size, density, and other aerodynamics properties). In some cases, separation gives a monotonic, systematic effect: smaller particles are ejected farther than heavier particles. Generally, however, the distance over which the particles will be thrown depends in a rather complicated way on the parameters of the particles and the parameters of motion of the gas. This property fits the faculae of type (d). Because we used the dimensionless form of the equations, our results can be also applied to other celestial bodies where the regolith contains volatile substances. This paper is an extension of our investigations on the origin of faculae (a).
Emotional Intelligence and E-training Readiness: A Survey Research at the Independent Authority for Public Revenue, Greece
Authors: Konstantinidou Evmorfia , Mavroidis Ilias 
Published: January 2025

Abstract
This study investigates the readiness for online education of the active employees of the Independent Authority for Public Revenue (IAPR) of the Hellenic Republic and its relationship with their level of emotional intelligence. The aim of the present work is to provide usable data to the designers of online programmes as well as to the trainers, and contribute to the planning and organisation of effective online training programmes. The Online Learning Readiness Scale (OLRS) and the Trait Emotional Intelligence Questionnaire—Short Form (TEIQue-SF) were adapted and used in this study. The statistical analysis of the results revealed that the largest percentage of the IAPR’s employees are ready for distance learning with the use of online learning tools. Furthermore, the employees’ level of emotional intelligence is an important factor that influences their readiness and should be considered in the design of the distance learning programmes.
Phénomènomorphoses Transformations du phénomène chez Gabellieri, Falque et Marion
Authors: Carreras Piero 
Published: January 2025

Abstract
Three of the most recent developments of the “theological turn” in French phenomenology deal explicitly with the question of the form of phenomena. Dealing with the works of Emmanuel Gabellieri, Emmanuel Falque and Jean-Luc Marion, this essay engages into a dialogue with and through French phenomenologists while discussing their philosophical stances – while also incorporating some ideas from authors of the Italian tradition (Sofia Vanni Rovighi, Virgilio Melchiorre and Enzo Melandri). The first part discusses the question of “barriers” and “limits” of phenomenology, followed by a closer examination of how this change in the conception of phenomena (“phenomenomorphosis”) is enacted by the three authors. Considering how the three of them exhibit the signs of what Gabellieri calls a “Christological turn,” the final part before the conclusions addresses the theoretical problem of a theological legitimation of phenomenology.
Influence of SiO2 nanoparticles on gametic cells of lime trees from urban area detected by flow cytometry
Authors: Grauda Dace , Kataševs Aleksejs , Belogrudova Inta , Čekstere-Muižniece Gunta , Butkauskas Dalius , Krasņevska Nikole , Leshenko Inga , Žagata Kārlis , Rashal Isaak 
Published: January 2025

Abstract
Silica or silicon dioxide nanoparticles (SiNPs) are one of the most widely spread nanoparticles in the environment, particularly, in urban areas in the form of dust. Influence of SiNPs on plant cells is unclear. This research was conducted to test a hypothesis that plant cell relative fluorescence and SiNP toxicity differ depending on the genetic properties and environmental conditions. Young pollen cells of lime trees in the mid to late one-nucleate developmental stage were found to be more sensitive to detect the influence of SiNPs and UV irradiation. Alteration of cell relative fluorescence depending on tree growth conditions was observed. Cells from trees grown in the urban area of Rīga had much lower reaction to SiNPs in comparison with cells from trees grown in the greenhouse. Lime trees growing for a long time in urban areas have complex adaptive features to a variable environment and can used as source-material to propagate lime trees for growing in such conditions. Flow cytometry can be applied for evaluation of plant reaction to factors that affect plants in the urban environment.
The Dynamics of Labor Income Share in an Era of Robotic Automation: A Panel Data Analysis in High-Level Automation Countries
Authors: Erkişi Kemal , Çetin Melike 
Published: January 2025

Abstract
This study examines the impact of robotic capital, physical capital, technological change, human capital, and trade globalization on labor income share dynamics in the era of robotic automation. Focusing on China, Germany, Japan, South Korea, and the United States – countries responsible for 79.2% of global industrial robotic installations from 2010 to 2023 – our analysis employs key variables such as labor income share, annual industrial robot installations, gross fixed capital formation, researchers in research and development, human capital index, and trade of goods and services. Estimations using Arellano-Bond, Generalized Estimating Equations, Driscoll-Kraay, and Arellano-Froot-Rogers methods reveal a consistent negative association between labor income share and robotic capital. Conversely, a positive relationship is observed with research and development. Notably, the study underscores the consistent negative impact of physical capital accumulation on labor income share across the Arellano-Bond, Driscoll-Kraay, and Arellano-Froot-Rogers methods. Furthermore, globalization, as assessed by the Arellano-Bond, Generalized Estimating Equations, and Driscoll-Kraay methods, is identified as a factor adversely affecting labor income share.
Strategi Komunikasi Pemerintah Provinsi di Indonesia Dalam Program Vaksinasi Booster Melalui X
Authors: Budiarsa Yohanes Thianika , Setiawan Wildan Namora Ichsan , Manalu S. Rouli , Ramadhanti Naura Iftika 
Published: January 2025

Jika dibandingkan dengan provinsi lain di Indonesia, akun X Pemerintah Provinsi (Pemprov) DKI Jakarta (@DKIJakarta) paling banyak membuat cuitan terkait program vaksinasi booster. Penelitian ini bertujuan untuk mengetahui strategi komunikasi dalam promosi kesehatan program vaksinasi booster oleh pemerintah provinsi melalui X. Metode campuran yaitu kombinasi antara analisis tematik dan analisis isi kuantitatif digunakan untuk menganalisis 74 tweets yang diunggah oleh akun X Pemerintah Provinsi DKI Jakarta, Jawa Barat, DI Yogyakarta, dan Bali pada periode Januari hingga Juni 2022. Data cuitan akun X provinsi-provinsi tersebut dianalisis menggunakan kerangka pemikiran fungsi microblogging yaitu information, community, dan action. Hasil penelitian menunjukkan bahwa dari tiga fungsi microblogging, tidak ada pemerintah provinsi yang menerapkan tiga fungsi sekaligus dalam produksi pesan promosi kesehatan mereka dan tidak ada satu pun dari keempat pemprov tersebut yang menerapkan fungsi komunitas. Pemprov DKI Jakarta dan Jawab Barat menerapkan fungsi informasi dan action, sedangkan pemprov Bali dan Yogyakarta hanya menerapkan fungsi informasi.Compared to other provinces in Indonesia, the X account of the DKI Jakarta Provincial Government (@DKIJakarta) posted the most tweets related to the booster vaccination program. This study aims to identify communication strategies for health promotion of the booster vaccination program by provincial governments through X. A mixed-method approach, combining thematic analysis and quantitative content analysis, was used to analyze 74 tweets uploaded by the X accounts of the provincial governments of DKI Jakarta, West Java, Yogyakarta Special Region, and Bali between January and June 2022. The tweets were analyzed using the microblogging function framework: information, community, and action. The findings reveal that none of the provincial governments applied all three microblogging functions simultaneously in their health promotion messages and none of the four provincial governments employed the community function. DKI Jakarta and West Java utilized the information and action functions, while Bali and Yogyakarta only applied the information function.
Identitas Komunikasi Penggemar K-Pop di Media Sosial X
Authors: Sutardi Alsa Aisiyah , Pradana Yoka , Nugrahani Rah Utami 
Published: January 2025

Penggemar K-pop merupakan komunitas yang aktif berinteraksi di media sosial, khususnya media sosial X. Mereka cenderung menggunakan identitas yang menggabungkan identitas asli dengan identitas sebagai penggemar K-pop (pseudonymity). Penelitian ini bertujuan menganalisis proses pembentukan identitas pseudonymity penggemar K-pop di media sosial X dengan menggunakan teori identitas komunikasi. Metode yang digunakan adalah kualitatif dengan desain studi kasus. Data dikumpulkan melalui wawancara semi-terstruktur terhadap tujuh informan yang dipilih secara purposive sampling, dengan kriteria penggemar K-pop, menggunakan akun pseudonymity, dan aktif di media sosial X. Studi dokumentasi terhadap aktivitas komunikasi di media sosial X juga dilakukan. Hasil penelitian menunjukkan bahwa identitas komunikasi penggemar K-pop dibentuk melalui empat lapisan yang saling berinteraksi. Pada lapisan personal, mereka melabeli diri sebagai penggemar normal atau “halu” yang berimajinasi memiliki hubungan sosial dengan idolanya. Di lapisan peningkatan, identitas terlihat dari nama akun, foto profil, dan aktivitas terkait idola. Pada lapisan relasi sosial, identitas dipengaruhi oleh lingkungan terdekat, seperti keluarga dan teman. Di lapisan komunal, penggemar menghadapi stigma negatif sebagai penggemar fanatik, meskipun sebagian tetap dianggap sebagai penggemar normal. K-pop fans are a community actively interacting on social media, particularly on platform X.They tend to use identities that combine their real identity with their identity as K-pop fans(pseudonymity). This study aims to analyze the process of forming pseudonymous identitiesamong K-pop fans on social media X using communication identity theory. The research employsa qualitative method with a case study design. Data were collected through semi-structuredinterviews with seven informants selected via purposive sampling, based on criteria includingbeing K-pop fans, using pseudonymous accounts, and actively engaging on social media X.Documentation of communication activities on social media X was also conducted. The findings reveal that K-pop fans' communication identity is constructed through four interrelated layers.In the personal layer, they label themselves as either "normal" fans or "halu" fans who fantasizeabout having social relationships with their idols. In the enacted layer, their identity is expressed through account names, profile pictures, and activities related to their idols. In the relational layer, their identity is shaped by close social circles such as family and friends. Finally, in the communal layer, fans face negative stigma as being fanatical, although some are still regarded as normal fans
Analisis Representasi dan Stereotip Gender dalam Film Animasi Anak
Authors: Rabani Hilmi Dafa , Wibowo Kunto Adi , Rahmawan Detta 
Published: January 2025

Film animasi anak sering kali menjadi media yang kuat dalam membentuk persepsi awal pada anak tentang peran dan stereotip gender. Penelitian ini mengkaji representasi gender dalam film animasi anak, dengan fokus pada atribut fisik, kepribadian, dan sosial karakter-karakter yang ditampilkan. Menggunakan metode analisis isi kuantitatif, penelitian ini menganalisis 100 karakter berbentuk manusia dari tujuh film animasi teratas yang dirilis antara tahun 2021-2023. Temuan menunjukkan representasi gender yang hampir seimbang, dengan karakter perempuan sering memainkan peran protagonis, yang bertentangan dengan stereotip gender tradisional. Meskipun ada kemajuan ini, stereotip fisik masih ada, dengan karakter perempuan digambarkan kurus dan tidak berotot, sementara karakter laki-laki digambarkan tinggi dan berotot. Penggambaran ini sesuai dengan standar kecantikan konvensional, mengaitkan daya tarik fisik dengan popularitas dan sifat positif, sementara karakter yang tidak sesuai dengan norma-norma ini kurang disukai. Penelitian ini menyoroti tantangan yang terus berlanjut dalam penggambaran media dan menyarankan bahwa meskipun peran karakter berkembang, representasi fisik stereotip tetap ada, yang berpotensi mempengaruhi persepsi anak-anak tentang standar tubuh ideal. Children's animated films often serve as a powerful medium in shaping children's early perceptions of gender roles and stereotypes. This study examines gender representation in children's animated films, focusing on the characters' physical, personality, and social attributes. This research analyzed 100 human-like characters from seven top-rated animated films released between 2021-2023 using a quantitative content analysis method. The findings reveal a nearly balanced gender representation, with female characters frequently playing protagonist roles against traditional gender stereotypes. Despite this progress, physical stereotypes persist, with female characters depicted as thin and not muscular, while male characters are portrayed as tall and muscular. These portrayals align with conventional beauty standards, associating physical attractiveness with popularity and positive traits, while characters that do not fit these norms are less favored. This study highlights the ongoing challenges in media portrayals and suggests that while character roles are evolving, stereotypical physical representations remain, potentially influencing children's perceptions of ideal body standards.
МІСЬКІ ТРАНСФОРМАЦІЇ В ТРАНСІЛЬВАНІЇ XVIII ст: ПРИКЛАД ДВОХ ПРОВІНЦІЙНИХ МІСТ, АЛЬБА-ЮЛІЇ ТА СЕБЕША
Authors: АНГЕЛ Келін 
Published: January 2025

Міста в Трансільванії з’явилися у перші десятиліття XIV ст. і пройшли через вражаючу еволюцію в середні віки. Проте протягом XVI – XVII ст. їх розвиток поступово зменшується. На початку Нового часу, незабаром після включення Князівства Трансільванія до імперії Габсбургів (бл. 1690 р.), новопридбана провінція мала лише три вільні королівські міста та 65 містечок. Міських поселень було мало, вони відзначалися невеликими розмірами, а їхня економіка відставала від інших міст імперії. Багато малих міст перебували в скрутному становищі, оскільки частково втратили населення та нагромадили значні борги перед державою. Після входження Трансільванії до імперії Габсбургів її міста продовжили розвиватися. Більшість із них за цей період зазнали морфологічних змін, вийшовши на новий етап укрупнення території. Водночас внутрішня тканина міської структури більшості старих міст не була порушена, за винятком кількох поселень місцевостей, які змінилися незначно. Проте периферійні території зазнали численних трансформацій, зокрема динамічно розширювалися передмістя. Одночасно зі значним територіальним розширенням зросла щільність забудови. Деякі населені пункти, такі як Альба-Юлія, зазнали масштабної реструктуризації, оскільки з’явилися нові райони та передмістя, сплановані відповідно до сучасних міських правил. У цій статті детально проаналізовано міський розвиток двох трансільванських міст: Себеша, вільного королівського міста в середньовіччі, столиці однойменного Саксонського села, важливого торгового й комерційного центру, а також Альба-Юлії – єпископської резиденції в середньовічний період і столиці Князівства Трансільванія після 1542 р. Після 1690 р. Альба-Юлія стала важливим військовим центром армії Габсбургів. У Себеші нові передмістя за сприяння місцевої влади були побудовані поза стінами середньовічного міста через внутрішній розвиток. Тоді ж Альба-Юлія зазнала радикальної трансформації, викликаної будівництвом нового укріплення з бастіонами, що оточували колишню середньовічну фортецю. Міське поселення, що існувало в околицях середньовічної фортеці, було перенесене на нові терени.
Ключові слова: Вільне королівське місто; oppidum; Князівство Трансільванія; Імперія Габсбургів; intra muros місто; передмістя.