bluuebunny/crossref_metadata_2025_split huggingface dataset:
F-circEA1 regulates cell proliferation and apoptosis through ALK downstream signaling pathway in non-small cell lung cancer
Authors: Huo Yinping , Lv Tangfeng , Ye Mingxiang , Zhu Suhua , Liu Jiaxin , Liu Hongbing , Song Yong 
Published: October 2021

AbstractStudies have confirmed that circular RNA (circRNA) has a stable closed structure, which plays an important role in the progression of tumors. Cancers with positive fusion genes can produce associated fusion circRNA (F-cirRNA). However, there are no reports concerning a role for F-circRNA of the echinoderm microtubule associated-protein like 4-anaplastic lymphoma kinase variant 1 (EML4-ALK1) in non-small cell lung cancer (NSCLC). Our study confirmed the existence of fusion circEA1 (F-circEA1) in NCI-H3122 cells (carrying the EML4-ALK1 gene), F-circEA1 was expressed both in the cytoplasm and nucleus as determined by fluorescence in situ hybridization (FISH) and Sanger sequencing. CCK8 and transwell assays showed that F-circEA1 was beneficial to cell proliferation, metastasis, and invasion. Overexpression of F-circEA1 can also promote cell proliferation, migration and invasion in A549 and SPCA1 cells (non-small cell lung cancer cell line not carrying the EML4-ALK1 gene). Interference with F-circEA1, induced cell cycle arrest and promoted apoptosis as determined by flow cytometry, and increased drug sensitivity to crizotinib in H3122 cells. F-circEA1 directly affected the expression of parental gene EML4-ALK1. Further research found that F-circEA1 can affect the downstream signaling pathway of ALK. In vivo, the growth rate of xenogeneic tumors was reduced and the protein expression level of EML4-ALK1 was significantly decreased in transplanted tumors measured by immunohistochemistry (IHC) after interference with F-circEA1. In conclusion, F-circEA1 can be considered as a proto-oncogene that regulates cell proliferation and apoptosis by affecting the expression of the parental gene EML4-ALK1 and its ALK downstream signaling pathway in non-small cell lung cancer.
Efficient Indexing of Top-k Entities in Systems of Engagement with Extensions for Geo-tagged Entities
Authors: Mondal Anirban , Kakkar Ayaan , Padhariya Nilesh , Mohania Mukesh 
Published: October 2021

AbstractNext-generation enterprise management systems are beginning to be developed based on the Systems of Engagement (SOE) model. We visualize an SOE as a set of entities. Each entity is modeled by a single parent document with dynamic embedded links (i.e., child documents) that contain multi-modal information about the entity from various networks. Since entities in an SOE are generally queried using keywords, our goal is to efficiently retrieve the top-k entities related to a given keyword-based query by considering the relevance scores of both their parent and child documents. Furthermore, we extend the afore-mentioned problem to incorporate the case where the entities are geo-tagged. The main contributions of this work are three-fold. First, it proposes an efficient bitmap-based approach for quickly identifying the candidate set of entities, whose parent documents contain all queried keywords. A variant of this approach is also proposed to reduce memory consumption by exploiting skews in keyword popularity. Second, it proposes the two-tier HI-tree index, which uses both hashing and inverted indexes, for efficient document relevance score lookups. Third, it proposes an R-tree-based approach to extend the afore-mentioned approaches for the case where the entities are geo-tagged. Fourth, it performs comprehensive experiments with both real and synthetic datasets to demonstrate that our proposed schemes are indeed effective in providing good top-k result recall performance within acceptable query response times.
Study the optical properties of drinking water supply by KUKL and KVWSIP in Kathmandu Valley
Authors: Karki Bhishma , Dhobi Saddam Husain , Dhobi Indra , Pandey Digvijay , Pandey Binay Kumar 
Published: October 2021

AbstractThe optical properties of two water supply samples Kathmandu Upatyaka Khanepani Limited (KUKL) and Kathmandu Valley Water Supply Improvement Project (KVWSIP) in the Kupondole Area, Lalitpur, Nepal show that the transmittance of light is higher for KVWSIP sample water than for KUKL. A large amount of work has been done to test the purities of KUKL and KVWSIP water supplies (chemically), but even their optical properties have not been studied. This method has no hazardous side effects or requires chemical method testing. In comparing the optical properties, the authors recommended that the public take KVWSIP water for good health and wealth rather than KUKL if they have an option.This is because KUKL is more contaminated and has more total dissolved solids (TDS) particles, while KVWSIP has fewer TDS particles. Therefore, if people take KVWSIP water in their daily life, they obtain relief from different types of water-related diseases.
Pictures and a thousand words: the experiences of significant others whose loved ones have a severe brain injury who are being discharged home
Authors: Checklin Martin , Stephens Delwyne 
Published: October 2021

AbstractPurpose:To investigate the experiences of significant others when their loved one with a severe acquired brain injury (ABI) is being discharged from an ABI-specific rehabilitation unit.Participants:Significant others of loved ones with an ABI participated in interviews close to their loved ones being discharged from inpatient ABI rehabilitation.Methods:Semi-structured interviews were conducted, and thematic analysis applied. Additionally, the drawing method was also used which involved participants drawing what it was like for them as their loved one was going home. Image analysis was then combined with the interview data.Results:Eight significant others participated in interviews on discharge and completed a drawing describing their experience. Five themes were identified (Change, Mixed feelings, Support of family and friends, Journey and Staff interactions).Conclusion:The experience of having a loved one with a severe ABI in rehabilitation is an emotional event. Compassionate communication, consistency of information and thorough discharge planning practices were cornerstones to enhancing the experience of significant others, empowering them to undertake their new role.
Effects of otosclerosis and stapedotomy on vestibular-evoked myogenic potentials
Authors: Satar B , Karaçaylı C , Çoban V K , Özdemir S 
Published: October 2021

AbstractObjectiveLimited data are available on the effects of otosclerosis and otosclerosis surgery on the utricle and saccule. This study aimed to determine the effect of otosclerosis and stapedotomy on vestibular-evoked myogenic potentials.MethodsThis retrospective study included 16 otosclerosis patients and 18 controls. Thirty-two ears of 16 patients with otosclerosis were divided into 2 groups based on whether the ear had been operated on or not. All patients and subjects underwent 500 Hz air- and bone-conducted ocular and cervical vestibular-evoked myogenic potentials testing.ResultsOverall comparison of response rates showed a significant difference among the groups. Further statistical tests showed that this difference arose from differences between both operated and unoperated groups and the control group, for air-conducted cervical and ocular vestibular-evoked myogenic potentials.ConclusionOtosclerosis and stapedotomy may affect the elicitability of vestibular-evoked myogenic potentials. Otosclerosis is associated with lower response rates for air-conducted ocular and cervical vestibular-evoked myogenic potentials, regardless of whether operated on. Having been operated on does not significantly increase the response rate of air-conducted vestibular-evoked myogenic potentials.
“ADMINISTRATIVE CONSTITUTIONALISM”: CONSIDERING THE ROLE OF AGENCY DECISION-MAKING IN AMERICAN CONSTITUTIONAL DEVELOPMENT
Authors: Bernstein David E. 
Published: October 2021

AbstractThe last decade or so has seen an explosion of scholarship by American law professors on what has become known as administrative constitutionalism. Administrative constitutionalism is a catchphrase for the role of administrative agencies in influencing, creating, and establishing constitutional rules and norms, and governing based on those rules and norms. Though courts traditionally get far more attention in the scholarly literature and the popular imagination, administrative constitutionalism scholars show that administrative agencies have been extremely important participants in American constitutional development. Section I of this essay identifies three different versions of administrative constitutionalism—(1) Engagement with Existing Constitutional Doctrine; (2) Resolving Questions of Statutory Meaning that Implicate Constitutional Questions; and (3) Shadow Administrative Constitutionalism—and provides examples from the scholarly literature to illustrate these distinct manifestations of administrative constitutionalism. Section II of this essay discusses the normative turn in administrative constitutionalism scholarship. Much of this normative literature is implicitly or explicitly premised on the notion that agencies are more likely to pursue progressive goals than are other government actors. Section III of this essay disputes the notion that agency constitutional decision-making is “democratic” and that agencies are naturally inclined to serve progressive goals. Finally, Section IV of this essay notes that scholars who support broad agency autonomy to work out and enforce their own constitutional visions have failed to consider how their work fits in with the economic and political science literature on agency behavior. One can predict, based on that literature, that agencies given broad autonomy under the guise of administrative constitutionalism will primarily be inclined to expand their scope and authority at the expense of countervailing considerations.
ECONOMISTS ON PRIVATE INCENTIVES, ECONOMIC MODELS, AND THE ADMINISTRATIVE STATE: THE CLASH BETWEEN HAPPINESS AND THE SO-CALLED PUBLIC GOOD
Authors: Peart Sandra J. 
Published: October 2021

AbstractThis essay examines the administrative state as a ubiquitous phenomenon that results in part from the mismatch of incentives. Using two dramatic episodes in the history of economics, the essay considers two types of mismatch. It then examines how economists increasingly endorsed the “general good” as a unitary goal for society, even at the expense of private hopes and desires. More than this, their procedures and models gave them warrant to design mechanisms and advocate for legislation and regulations to “fix” the supposedly suboptimal choices of individuals in service to the overarching goal. The rise of New Welfare Economics dealt an additional blow to the sovereignty of individual motivations, notwithstanding that Hayek and Buchanan warned that this engineering approach allowed social goals to override individual preferences. Throughout, the argument is that it is important to recognize that people within or advising the administrative state are influenced by the same sorts of (private) motivations as actors throughout the economy.
Non-pharmaceutical interventions and inoculation rate shape SARS-CoV-2 vaccination campaign success
Authors: Galanti Marta , Pei Sen , Yamana Teresa K. , Angulo Frederick J. , Charos Apostolos , Khan Farid , Shea Kimberly M. , Swerdlow David L. , Shaman Jeffrey 
Published: October 2021

Abstract
Nearly 1 year into the coronavirus disease 2019 pandemic, the first severe acute respiratory syndrome coronavirus 2 vaccines received emergency use authorisation and vaccination campaigns began. A number of factors can reduce the averted burden of cases and deaths due to vaccination. Here, we use a dynamic model, parametrised with Bayesian inference methods, to assess the effects of non-pharmaceutical interventions (NPIs) (such as social distancing, mask mandates, school and workplace closure), and vaccine administration and uptake rates on infections and deaths averted in the United States. We show that scenarios depicting higher compliance with NPIs avert more than 60% of infections and 70% of deaths during the period of vaccine administration, and that increasing the vaccination rate from 5 to 11 million people per week could increase the averted burden by more than one-third. These findings underscore the importance of maintaining NPIs and increasing vaccine administration rates.
Trajectories of depression and anxiety symptoms over time in the transition to university: Their co-occurrence and the role of self-critical perfectionism
Authors: Levine Shelby L. , Tabri Nassim , Milyavskaya Marina 
Published: October 2021

AbstractLittle is known about how mental health symptoms develop during the transition to university. Most anxiety and depression research fails to consider how symptom development differs over time across different individuals, and how symptom co-occurrence influences the severity of mental health problems. Students (N = 658) completed online surveys on mental health prior to starting university and every 2 months until April. To better understand mental health problems during this transitional period, latent class growth curve analyses were run to determine how anxiety and depressive symptoms co-develop over time, as well, if self-critical perfectionism was a transdiagnostic risk factor for more severe symptom trajectories in this transition. About 40% of students experienced depression and anxiety symptoms prior to entering/during the transition to university. There is substantial variation between students in terms of how they experience depression and anxiety symptoms, and research needs to take this heterogeneity into account to properly identify which students might benefit most from resources. Self-critical perfectionism was a transdiagnostic risk factor, such that students higher in this trait experienced more severe anxiety and depressive symptom trajectories during this transition. This research further implicates the importance of understanding and studying individual differences in symptom development.
Neighbourhood food typologies, fast food outlet visitation and snack food purchasing among adolescents in Melbourne, Australia
Authors: Loh Venurs HY , Poelman Maartje , Veitch Jenny , McNaughton Sarah A , Leech Rebecca , Timperio Anna 
Published: October 2021

AbstractObjective:Despite the increased attention on neighbourhood food environments and dietary behaviours, studies focusing on adolescents are limited. This study aims to characterise typologies of food environments surrounding adolescents and their associations with fast food outlet visitation and snack food purchasing to/from school.Design:The number of food outlets (supermarket; green grocers; butcher/seafood/deli; bakeries; convenience stores; fast food/takeaways; café and restaurants) within a 1 km buffer from home was determined using a Geographic Information System. Adolescents’ self-reported frequency of fast food outlet visitation and snack food purchasing to/from school. Latent Profile Analysis was conducted to identify typologies of the food environment. Cross-sectional multilevel logistic regression analyses were conducted to examine the relationships between food typologies, fast food outlet visitations and snack food purchasing to/from school.Setting:Melbourne, Australia.Participants:Totally, 410 adolescents (mean age= 15·5 (sd = 1·5) years).Results:Four distinct typologies of food outlets were identified: (1) limited variety/low number; (2) some variety/low number; (3) high variety/medium number and (4) high variety/high number. Adolescents living in Typologies 1 and 2 had three times higher odds of visiting fast food outlets ≥1 per week (Typology 1: OR = 3·71, 95 % CI 1·23, 11·19; Typology 2: OR = 3·65, 95 % CI 1·21, 10·99) than those living in Typology 4. No evidence of association was found between typologies of the food environments and snack food purchasing behaviour to/from school among adolescents.Conclusion:Local government could emphasise an overall balance of food outlets when designing neighbourhoods to reduce propensity for fast food outlet visitation among adolescents.
Subverting the prison: the incarceration of stigmatised older Japanese
Authors: Lawson Carol 
Published: October 2021

AbstractThis paper examines the presence of lonely, isolated and impoverished older citizens in Japan's prison population, many of whom have turned to petty crime only recently and arguably lack a genuine need for corrective services. The paper offers empirical evidence drawn from a mixed-methods study that appears to confirm their compliant, ‘law-abiding’ attributes. It argues that their influx into prisons can be seen, at least in part, as citizens who are already socially excluded and stigmatised leveraging law to assert an additional risk-laden and stigmatised identity, which provides protection. The outcome is the subversion of prisons as de facto aged-care communities. This analysis resonates with an emerging body of literature that Chua and Engel (2018; 2019) have described as the ‘Identity’ school of legal-consciousness scholarship. This literature centres on empirical studies of marginalised cohorts who leverage legal structures to embrace an identity that complicates their stigma while providing desired protections.
External Validation and Test-Retest Reliability of Postpartum Bonding Questionnaire in Spanish Mothers
Authors: Torres-Giménez Anna , Roca-Lecumberri Alba , Sureda Bàrbara , Andrés-Perpiña Susana , Palacios-Hernández Bruma , Gelabert Estel , Farré-Sender Borja , Subirà-Álvarez Susana , García-Esteve Lluïsa 
Published: October 2021

Abstract
The aim of the present study was to validate the Spanish Postpartum Bonding Questionnaire (PBQ) against external criteria of bonding disorder, as well as to establish its test-retest reliability. One hundred fifty-six postpartum women consecutively recruited from a perinatal mental health outpatient unit completed the PBQ at 4–6 weeks postpartum. Four weeks later, all mothers completed again the PBQ and were interviewed using the Birmingham Interview for Maternal Mental Health to establish the presence of a bonding disorder. Receiver operating characteristic curve analysis revealed an area under the curve (AUC) value for the PBQ total score of 0.93, 95% CI [0.88, 0.98], with the optimal cut-off of 13 for detecting bonding disorders (sensitivity: 92%, specificity: 87%). Optimal cut-off scores for each scale were also obtained. The test-retest reliability coefficients were moderate to good. Our data confirm the validity of PBQ for detecting bonding disorders in Spanish population.
Neotectonic Subsidence Along the Cenozoic Kunlun Fault (Tibetan Plateau)
Authors: Yan Dada , Wünnemann Bernd , Zhang Yongzhan , Hartmann Kai , Diekmann Bernhard , Andersen Nils 
Published: October 2021

AbstractMany lake basins on the Tibetan Plateau are affected by tectonic activity. It is therefore important to consider seismotectonic influence on lake evolution when discussing climate impact on hydrology and sediment budgets. Lake Donggi Cona serves as an example to demonstrate the influence of the Kunlun left‐lateral strike‐slip fault on lake formation with subsidence in the pull‐apart basin. The results show that comparable fluvial sandy sediments generated at low lake levels during the Late Glacial and early Holocene occur at different water depths within a double lake‐internal pull‐apart structure, suggesting mean subsidence rates of 2.6–4.3 mm/a since 13.5 cal. ka BP. Such pulses prevailed throughout the Holocene, pointing to repeated seismic events and ongoing neotectonic activity. Sediment distribution and changing morphological shape by subsidence are important factors that affected other lakes on the Tibetan Plateau and enable us to distinguish between neotectonic and paleoclimatic impacts.
The Diurnal Cycle of Winter Season Temperature Errors in the Operational Global Forecast System (GFS)
Authors: Patel Ronak N. , Yuter Sandra E. , Miller Matthew A. , Rhodes Spencer R. , Bain Lily , Peele Toby W. 
Published: October 2021

AbstractForecasts from NOAA's Global Forecast System (GFS) and the High‐Resolution Rapid Refresh (HRRR) weather models are matched to surface observations for the winter season of November 2019 to March 2020 at 210 airports across the United States. The 2‐m temperature errors, conditioned on observed weather conditions such as cloud cover amount and wind speed, are used to determine the nature of systematic model biases. We observe a strong diurnal cycle in 2‐m temperature errors in the GFS in conditions with 50% and 25% sky cover, with a 1°C warm bias at night and a 2°C cold bias during the day. The HRRR, which uses a different set of physical parameterizations, does not have a clear diurnal cycle in errors under the same conditions. These results highlight the utility of weather‐conditional comparisons across the diurnal cycle to diagnose sources of model weaknesses and to target model improvements.
A 3D MHD‐Particle Tracing Model of Na+ Energization on Mercury's Dayside
Authors: Glass Austin N. , Raines Jim M. , Jia Xianzhe , Tenishev Valeriy , Shou Yinsi , Aizawa Sae , Slavin James A. 
Published: October 2021

AbstractData collected by the Fast Imaging Plasma Spectrometer (FIPS) aboard the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft showed singly charged Na+‐group ions at energies of between 1 and 13 keV in Mercury's northern planetary cusp. Most of these ions are likely formed by either photoionization or charge exchange of exospheric Na atoms, with initial energies of approximately 1 eV or less. FIPS observations did not establish which acceleration mechanism most reasonably accounts for this energy gain. Using the Adaptive Mesh Particle Simulator (AMPS) model, we undertake kinetic simulations of 1 eV Na+ test particles through the electric and magnetic fields output from the Block Adaptive Tree Solar wind Roe‐type Upwind Scheme (BATSRUS) global magnetohydrodynamic (MHD) model of Mercury's magnetosphere, in search of plausible explanations for the source of this energization. We find that Na+ with initial energy of 1 eV are readily picked up by the Dungey cycle return flow in the dayside magnetosphere. In some cases, this flow provides the energy for the ions to escape into the magnetosheath, and in other cases it energizes the ions to hundreds of eV before they pass immediately into the cusp. Those that escape can be rapidly picked up into the magnetosheath flow, where they are accelerated by pickup again up to tens of keV. These one‐ and two‐stage pickup processes on Mercury's dayside can account for the energies of many of the Na+ ions observed in Mercury's northern magnetospheric cusp by MESSENGER.