bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-haul COVID: Healthcare Utilization and Medical Expenditures 6 Months Post-diagnosis
Authors: Koumpias Antonios Marios , Schwartzman David , Fleming Owen 
Published: December 2021

Abstract
Background

Despite evidence that long-term COVID-19 symptoms may persist for up to a year, their implications for healthcare utilization and costs 6 months post-diagnosis remain unexplored.
Methods

Our objective is to determine for how many months post-diagnosis healthcare utilization and costs of COVID-19 patients persist above pre-diagnosis levels and explore response heterogeneity across age groups. This population-based retrospective cohort study followed COVID-19 patients’ healthcare utilization and costs from January 2019 through March 2021 using claims data provided by the COVID-19 Research Database. The patient population includes 328,777 individuals infected with COVID-19 during March-September 2020 and whose last recorded claim was not hospitalization with severe symptoms. We measure the monthly number and costs of total visits and by telemedicine, preventive, urgent care, emergency, immunization, cardiology, inpatient or surgical services and established patient or new patient visits.
Results

The mean (SD) total number of monthly visits and costs pre-diagnosis were .4805 (4.2035) and 130.67 (1,216.66) dollars compared with 1.1998 (8.5184) visits and 341.7576 (2,439.5581) dollars post-diagnosis. COVID-19 diagnosis associated with .7338 (95% CI, 0.7175 to 0.7500 visits; P < .001) more total healthcare visits and an additional $215.40 (95% CI, 210.76 to 220.00; P<.001) in monthly costs. Excess monthly utilization and costs for individuals under 19 years old subside after 5 months to .021 visits and $3.7, persist at substantial levels for all other groups and most pronounced among individuals 50-59 (.236 visits and $78.60) and 60-69 (.196 visits and $73.10) years old.
Conclusions

This study found that COVID-19 diagnosis was associated with increased healthcare utilization and costs 6 months post-diagnosis. These findings imply a prolonged burden to the US healthcare system from medical encounters of COVID-19 patients and increased spending.
A Comprehensive In Silico Perspective For Discovery of Novel Inhibitory Candidates Targeting Versatile Transcriptional Repressor MBD2
Authors: Çalışkaner Zihni Onur 
Published: December 2021

Abstract
Genome methylation is a key epigenetic mechanism in various biological events such as development, cellular differentiation, cancer progression, aging, and iPSC reprogramming. Crosstalk between DNA methylation and regulation in gene expression is employed through MBD2, known as reader of DNA methylation and suggested as a drug target. Despite its magnitude of significance and rationale of nomination, a scarcely limited number of druggable ligands has been detected so far. Hence, we screened a comprehensive compound library, and then certain of them were subjected to computational docking analysis by targeting the methylated DNA-binding domain of human MBD2. We could detect reasonable binding energies and docking residues presumably located in druggable pockets. Docking results were also validated via MD simulation and per-residue energy decomposition calculation. Drug-likeness of tested ligands was assessed through ADMET prediction in order to foresee off-target side effects for future studies. Herein, on the basis of collaborating approaches such as molecular docking, MD simulation, energy decomposition, and ADMET prediction, notably two compounds named CID3100583 and 8,8-Ethylenebistheophylline, have become prominent as novel candidates, possibly disrupting MBD2MBD–DNA interaction. Hereby, these compounds exhibit a promising usage potential in a wide range of implementations from cancer treatment to somatic cell reprogramming protocols.
Hemoglobin, albumin, lymphocytes and platelets (HALP) score is a useful predictor of survival in patients with recurrent glioblastoma multiforme treated with bevacizumab plus irinotecan
Authors: Korkmaz Mustafa , Eryılmaz Melek Karakurt , koçak Mehmet zahid , Demirkıran Aykut , Karaağaç mustafa , araz murat , Artaç Mehmet 
Published: December 2021

Abstract
Backgrounds: We aimed to investigate whether the HALP score is a predictive marker in patients with recurrent GBM who were given bevacizumab plus irinotecan.Methods: We compared the survival of patients followed up in our clinic with the diagnosis of recurrent GBM and treated with bevacizumab plus irinotecan, according to HALP score.Results: Median PFS and OS were 4.5 (0.9-14.9) and 8 (0.9-21.3) months, respectively. The median PFS of the low HALP score group was 1.85 (1.3-3.37) months, and of the high HALP score group was 4.96 (0.9-14.9) months (p=0.03). The OS of the high HALP score group (9.63 [7.28-11.9]) was statistically higher compared with low HALP score group (2.26 [0.88-3.65]) (p<0.001). In univariate analysis HALP score was a significant prognostic factor; patients with low HALP score had a poorer prognosis than high HALP score (HR: 0.063, p<0.001). The multivariate analysis showed that HALP score (p=0.003), and residual tumor (p=0.029) were significant prognostic factors. In multivariate Cox regression analysis, low HALP score was a significant poor prognostic factor for OS compared with high HALP score (HR: 0.063, p<0.001). Conclusion: We showed that the HALP score at the start of treatment is an independent prognostic factor for PFS and OS in patients with recurrent GBM treated with bevacizumab plus irinotecan. The HALP score, which can be easily calculated by routine tests before chemotherapy, can be used as a predictive marker for bevacizumab treatment decision.
Ansiedade entre estudantes do ensino médio, gênero e escolaridade
Authors: Cordeiro da Graça de Oliveira Guilherme , Boruchovitch Evely 
Published: December 2021

A ansiedade é uma sensação associada à preocupação, à angústia ou ao medo que acarreta consequências negativas para aprendizagem. O presente artigo tem por objetivo caracterizar a ansiedade de estudantes do Ensino Médio e examinar se existem diferenças em relação ao gênero e ao ano escolar dos alunos. Participaram da pesquisa 957 estudantes do Ensino Médio de escolas públicas e particulares de duas cidades brasileiras. Os dados foram coletados pela escala de ansiedade do Inventário de Estratégias de Estudo e Aprendizagem - Learning and Study Strategies Inventory (LASSI). Diferenças significativas nos escores da escala de ansiedade em relação ao gênero e à escolaridade foram encontradas. As alunas reportaram significativamente mais ansiedade do que os alunos. Os estudantes do terceiro ano apresentaram menores índices de ansiedade do que os demais. Espera-se contribuir para o avanço das pesquisas sobre o tema e nortear ações que reduzam a ansiedade no contexto educativo.
Typologie et fonctions morphosyntaxiques des préfixes verbaux ha- et -ha- en kirundi (JD62)
Authors: NSHEMEZIMANA Ernest , Mberamihigo Ferdinand 
Published: December 2021

Cet article étudie la typologie et le fonctionnement morphosyntaxique des préfixes verbaux ha-/-ha- attestés en kirundi. Empruntant une démarche du corpus, nos résultats d’analyse font état de deux types de ha : un préfixe locatif référant à la classe locative 16 et un préfixe non-référentiel à caractère explétif. Ces derniers ont des usages et une fréquence d’emploi assez différents. Le plus dominant dans les emplois est le préfixe ha explétif, surtout lorsqu’il est sujet du verbe. Celui-ci est essentiellement utilisé comme marqueur du sujet sur le verbe dans certaines structures à sujet inversé, après que ce dernier ait perdu la capacité d’assurer l’accord du verbe suite à sa délocalisation de sa position canonique. Parfois, il se présente comme objet pronominal explétif en conférant une valeur existentielle au verbe. Pour le préfixe locatif, ses fonctions varient entre marqueur d’accord verbal et marqueur pronominal des arguments sur le verbe donné.
ETNOGRAFIA MULTIESPÉCIES DE UM PROJETO DE REINTRODUÇÃO DE ARARAJUBAS (GUARUBA GUAROUBA) NA METRÓPOLE AMAZÔNICA (BELÉM/PA)
Authors: Silva Matheus Henrique Pereira da , Pedrosa Neto Cícero , Silveira Flávio Leonel Abreu da 
Published: December 2021

Este artigo apresenta dados referentes a uma pesquisa etnográfica multiespecífica em andamento realizada no Parque Estadual do Utinga (PEUt), localizado na região metropolitana de Belém (PA), na Amazônia oriental brasileira. O Parque em questão é uma Unidade de Conservação Estadual criada com o objetivo de contribuir para a conservação dos ecossistemas naturais amazônicos de grande relevância ecológica e beleza cênica, além de estimular a pesquisa científica e atividades relacionadas à Educação Ambiental e turismo ecológico. Dessa maneira, buscamos descrever os emaranhamentos aviários relacionados ao projeto “Reintrodução e Monitoramento de Ararajubas (Guarouba guarouba) em Unidades de Conservação da Região Metropolitana de Belém”, a partir das relações entre a avifauna e o biólogo responsável pelo seu manejo técnico, alimentação, asselvajamento e outros cuidados diários, além de repensarmos as agências da vida humana, neste caso, simultaneamente, à causa central dessas extinções e agentes de conservação das espécies situados no contexto de co-extinções em níveis globais e locais. As estratégias e práticas de conservação e reintrodução da espécie no PEUt se relacionam a co-criação de mundos multiespécies, bem como permitem repensar as relações e os sentidos entre natureza e cultura (o sentido da extinção e da vida das aves junto aos humanos) em suas dimensões éticas e o futuro da vida das espécies na Amazônia.
Uso do ácido hialurônico para a reconstrução da papila interdental
Authors: Souza Thaís Teixeira de Abreu , Pimentel Rafael Meira , Barbosa Carla Cristina Neves , Barbosa Oswaldo Luiz Cecilio 
Published: December 2021

Aponta-se, que a escassez da papila, o acréscimo gengival, a pouca densidade do rebordo e a recessão gengival, tem causado grande perda da harmonia da gengiva com os dentes, resultando assim falta do equilíbrio estético e alterações fonéticas, o que acaba acarretando impactações alimentares, prejudicando os tecidos periodontais. O ácido hialurônico (AH) pela sua função anti-inflamátória desempenha um papel de fundamental importância no equilíbrio tecidual, além de ser um método bastante seguro e pouco invasivo. Diante disso, o trabalho em questão terá como base metodológica, a pesquisa bibliográfica, optando pela busca de obras que também discutam sobre o tema proposto e que englobem um número significativo de informações que contribuam com a construção da redação do trabalho, sendo elas: revistas online, periódicos, artigos e trabalhos acadêmicos, nas bases de dado, LILACS, Scielo, PubMed e Google Acadêmico. Sendo o objetivo central deste trabalho, se posicionar diante da análise da utilização do ácido hialurônico para fins de reconstrução da papila interdental, apresentando procedimentos que possam demonstrar a eficácia do uso do ácido hialurônico nesse quadro.
Palavras-chave: Ácido Hialurónico; Papila Dental; Recessão Gengival.
Ultrasonographic Applications in the Thorax
Authors: Gunluoglu Mehmet Zeki , Ormeci Tugrul , Sen Selva 
Published: December 2021

Abstract:
Rapid developments and increasing technological knowledge have changed perspectives
on ultrasonography. Previously, ultrasonography was used to evaluate chest wall pathologies, to
distinguish between pleural effusion and consolidation, to evacuate pleural effusion, or to evaluate
diaphragm movement. Today, it is also used in a wide range of pleural and parenchymal diseases.
Ultrasonography is not just used in the emergency department and the intensive care units, it is also
utilized in many clinical branches dealing with the respiratory system-due to its ease of use, fast access,
price advantage, non-radiation exposure, higher diagnostic sensitivity, and specificity in
many clinical situations-and has become a part of the examination. In this review, we have assessed
not just transthoracic ultrasonography but also more focal and targeted sonographic applications,
such as the endobronchial ultrasound and esophageal ultrasound.
Support for Texting-Based Condom Negotiation Among Forcibly Displaced Adolescents in the Slums of Kampala, Uganda: Cross-sectional Validation of the Condom Use Negotiated Experiences Through Technology Scale
Authors: Okumu Moses , Logie Carmen H , Ansong David , Mwima Simon , Hakiza Robert , Newman Peter A 
Published: December 2021

Background
Promoting sexual health among forcibly displaced adolescents is a global public health priority. Digital sexual communication strategies (eg, sexting) may increase adolescents’ confidence in discussing sexual health issues and negotiating condom use. However, limited evidence exists describing validated measures for text-based condom negotiation in the literature.

Objective
This study helps fill this gap by adapting and examining the psychometric properties of a condom use experience through technology (condom use negotiated experiences through technology [CuNET]) scale.

Methods
Using peer network sampling, 242 forcibly displaced adolescents (aged 16-19 years) living in Kampala’s slums were recruited for participation between January and March 2018. A subscale (embarrassment to negotiate condom use) of the Multidimensional Condom Attitudes Scale was adapted to incorporate sexting, yielding CuNET. Participants were randomly assigned to calibration and validation subsamples to conduct exploratory and confirmatory factor analyses to establish and validate the scale. CuNET measured participants’ support levels for texting-based condom negotiation via sexting based on gender, and multivariable logistic regression was used to explore its associations with sexual health outcomes (recent consistent condom use, access to sexual and reproductive health services, and lifetime sexually transmitted infection testing).

Results
The one-factor CuNET with the validation sample was valid (χ24=5.3; P=.26; root mean square error of approximation=0.05, 90% CI 0.00-0.16; comparative fit index=0.99; Tucker-Lewis index=0.99; standardized root mean square residual=0.006), and reliability (Cronbach α=.98). Adolescent girls showed significantly lower levels of support for using sexting to negotiate condom use (mean 13.60, SE 0.70 vs mean 21.48, SE 1.23; P=.001). In multivariable analyses, a 1-point increase in the CuNET score was associated with increased odds of recent consistent condom use (adjusted odds ratio [aOR] 1.73, 95% CI 1.24-2.41) but not with access to sexual and reproductive health services (aOR 1.51, 95% CI 0.99-2.30) or lifetime sexually transmitted infection testing (aOR 0.90, 95% CI 0.64-1.26).

Conclusions
The unidimensional CuNET scale is valid and reliable for forcibly displaced adolescents living in slums in Kampala, gender-sensitive, and relevant for predicting consistent condom use among urban displaced and refugee adolescents. Further development of this scale will enable a better understanding of how adolescents use digital tools for condom negotiation.
Web-Based Lifestyle Interventions for Survivors of Cancer: Usability Study
Authors: Williams Victoria , Brown Nashira , Moore Justin Xavier , Farrell David , Perumean-Chaney Suzanne , Schleicher Erica , Fontaine Kevin , Demark-Wahnefried Wendy , Pekmezi Dori 
Published: December 2021

Background
Internet-based lifestyle programs are increasingly being used to deliver health behavior change interventions to survivors of cancer. However, little is known about website use in this population or its association with healthy lifestyle changes.

Objective
The aim of this study is to describe lifestyle intervention website use (log-ins, time on website, and page views) among survivors of cancer and patterns of use by participant characteristics. In addition, associations were explored between website use and changes in healthy lifestyle knowledge and practice.

Methods
A total of 35 survivors of cancer were recruited between August 2017 and 2018 to participate in a 2-week, single-arm pilot test of the SurvivorSHINE lifestyle intervention website. Knowledge and practices related to healthy diet and physical activity behaviors were measured at baseline and follow-up. Website use (eg, time spent on the website, frequency of log-ins, and page views) were collected from the SurvivorSHINE administrative site during the intervention period. Patterns of use were examined by participants’ gender and race. Correlations between website use and changes in healthy lifestyle knowledge, physical activity, diet, and weight were explored. Mann–Whitney U tests were used to compare demographic factors on website use.

Results
Participants logged into the SurvivorSHINE intervention website an average of 3.2 (SD 2) times over the 2-week period and spent a total average of 94 (SD 56) minutes viewing the website during the intervention. Examining website activity, 1905 page views were logged. The User Profile (344 page views) and Home sections (301 page views) were the most frequently visited components. No associations were observed between the frequency of log-ins or the total time on the website, improvements in knowledge related to healthy lifestyles, or changes in body weight or dietary intake. However, the total time on the website was positively correlated with improvements in accelerometer-measured physical activity (r=0.74; P=.02) and self-reported physical activity (r=0.35; P=.04).

Conclusions
Survivors of cancer demonstrated clear interest in a diet and exercise intervention website, as evidenced by their frequency of log-ins, page views on numerous features, and total viewing time. Moreover, increased website use was correlated with improvements in physical activity.
Identification of Potential Vaccine Candidates Against SARS-CoV-2 to Fight COVID-19: Reverse Vaccinology Approach
Authors: Gupta Ekta , Mishra Rupesh Kumar , Kumar Niraj Ravi Ranjan 
Published: December 2021

Background
The recent emergence of COVID-19 has caused an immense global public health crisis. The etiological agent of COVID-19 is the novel coronavirus SARS-CoV-2. More research in the field of developing effective vaccines against this emergent viral disease is indeed a need of the hour.

Objective
The aim of this study was to identify effective vaccine candidates that can offer a new milestone in the battle against COVID-19.

Methods
We used a reverse vaccinology approach to explore the SARS-CoV-2 genome among strains prominent in India. Epitopes were predicted and then molecular docking and simulation were used to verify the molecular interaction of the candidate antigenic peptide with corresponding amino acid residues of the host protein.

Results
A promising antigenic peptide, GVYFASTEK, from the surface glycoprotein of SARS-CoV-2 (protein accession number QIA98583.1) was predicted to interact with the human major histocompatibility complex (MHC) class I human leukocyte antigen (HLA)-A*11-01 allele, showing up to 90% conservancy and a high antigenicity value. After vigorous analysis, this peptide was predicted to be a suitable epitope capable of inducing a strong cell-mediated immune response against SARS-CoV-2.

Conclusions
These results could facilitate selecting SARS-CoV-2 epitopes for vaccine production pipelines in the immediate future. This novel research will certainly pave the way for a fast, reliable, and effective platform to provide a timely countermeasure against this dangerous virus responsible for the COVID-19 pandemic.
Family social capital on public respond to COVID-19 in Indonesia
Authors: Supriyati Supriyati , Habibah Kun , Wahyuni Ade , Wahab Rafif Adianto Abdul , Halim Kenji Sebastian , Nugroho Erdananda Aditya , Soddiq Mohamad Sofyan 
Published: December 2021

Background: The Coronavirus Disease 2019 (COVID-19) gave impact on the various sectors, not limited to the health sector. In the other hand, social capital was help Indonesian community from the 1998 crisis. This study was aimed to describe the family social capital on COVID-19 prevention and examine factors contribute to family social capital among Indonesia citizen.Method: Cross-sectional data was derived from community survey conducted in Indonesia (February, 2021). A number of 581 Indonesian citizen aged 18 – 59 years old had participated in this study. Data was collected by using online questionnaire that distributed through social media. Furthermore, univariate, bivariate, and multivariate analysis were carried out in this study.Result: Most of respondent (55%) had high family social capital. The family social capital include (1) education function, (2) protective function, and (3) reinforcement function. They were discussed with their family member about the hazard of COVID-19, health protocol as strategy for COVID-19 prevention, and tried to remind each other to apply health protocol in the daily activities. Furthermore, their family were provide face mask and hand sanitizer for family member as a tool of COVID-19 prevention. Family was the second highest information source (65%) regarding Covid-19 and prevention among family member. In addition, there was a significant association between perception toward health protocol (p = 0.000), vulnerable status (p = 0.044), and economic status (p = 0.000), and family social capital. Community empowerment in the COVID-19 prevention through family social capital was challenging. Conclusion: This study demonstrated that Indonesian community had high family social capital. Moreover, public health expert need to empower family social capital in the COVID-19 prevention.
Edukacja nieformalna jako komponent twórczej resocjalizacji w MOW
Authors: Kromolicka Barbara 
Published: December 2021

Edukacja nieszkolna zwana nieformalną, to edukacyjne oddziaływanie na dzieci i młodzież wybiegające poza program nauczania w tradycyjnym trybie pracy szkoły czy placówki opiekuńczej, resocjalizacyjnej. Szczególnie w pracy resocjalizacyjnej poszukuje się twórczych rozwiązań, które sprostałyby wyzwaniom jakie stawia przez wychowawcami praca z osobami niedostosowanymi społecznie. W artykule przedstawiono efekty twórczej resocjalizacji wychowanków w Młodzieżowym Ośrodku Wychowawczym w Trzebieży wykorzystującym walory projektu międzynarodowego ERASMUS+. Wykorzystanie tego projektu jest innowacyjnym podejściem w resocjalizacji na skalę całej Polski. Ośrodek ten jest bowiem jedynym w Polsce, który realizował międzynarodową wymianę młodzieży do czasu przed pandemią Covid -19, która ograniczyła wyjazdy, średnio aż trzy projekty rocznie.
Reintegracja społeczna młodzieży w warunkach współczesnego państwa a prawa człowieka. Wybrane przykłady i wnioski
Authors: Solarz Piotr 
Published: December 2021

W artykule przedstawione zostały nowe podejścia do reintegracji społecznej młodzieży które cechuje bardziej przyjazne dla młodzieży rozwiązanie jakim jest propozycja sformułowana w dokumencie pt:” Manuel d’introduction pour la prévention de la récidive et la réinsertion sociale des délinquants”, którego polski odpowiednik to „Zapobieganie recydywie a reintegracja społeczna”, odnosząca się do przykładów młodzieży i nieletnich we współczesnej Francji i powiązania jej z prawami człowieka. Innowacyjne podejście zapobiegania recydywie a reintegracja społeczna jest ukierunkowane na po pierwsze zapewnieniu pomocy skazanej młodzieży oraz objęcie ich specjalnym nadzorem aby nauczyć skazanego życia bez agresji i przemocy i uniemożliwić uniknięcia ewentualnego powrotu do zachowań o charakterze przestępczym.