bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychobiotic Supplementation of PS128TM Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study
Authors: Wu Shu-I , Wu Chien-Chen , Tsai Pei-Joung , Cheng Li-Hao , Hsu Chih-Chieh , Shan Ian-Kai , Chan Po-Ying , Lin Ting-Wei , Ko Chih-Jung , Chen Wan-Lin , Tsai Ying-Chieh 
Published: March 2021

Background: Information technology (IT) is an industry related to the production of computers, information processing, and telecommunications. Such industries heavily rely on the knowledge and solutions provided by IT specialists. Previous reports found that the subjective stress scores were higher in IT specialists who developed diabetes, hypertension, and depression. Specific probiotics, known as psychobiotics, may alleviate stress and mood symptoms. This study aimed to examine whether an 8-week intervention of a novel psychobiotic, Lactobacillus plantarum PS128TM (PS128TM), improved self-perceived stress and mood symptoms among high-stress IT specialists.Methods: This open-label, single-arm, baseline-controlled study included IT specialists from a large IT company in Northern Taiwan. Participants with a Perceived Stress Scale (PSS) 10-item version score of 27 or higher were included. Participants were asked to take two capsules containing PS128TM powder, equivalent to 20 billion colony-forming units, daily. Self-report measures, such as the Job Stress Scale, Visual Analog Scale of Stress, the Insomnia Severity Index, the State and Trait Anxiety Index, the Questionnaire for Emotional Trait and State, the Patient Health Questionnaire, the Quality of Life Enjoyment and Satisfaction Questionnaire, and Gastrointestinal Severity Index were compared at baseline and at the end of the trial period. The primary outcome was a 20% reduction in the PSS score at endpoint. Objective measures included salivary levels of stress biomarkers, including cortisol, α-amylase, immunoglobulin A, lactoferrin, and lysozymes, as well as results of the Test of Attentional Performance.Results: Of the 90 eligible IT specialists, 36 met the inclusion criteria. After the 8-week trial period, significant improvements in self-perceived stress, overall job stress, job burden, cortisol level, general or psychological health, anxiety, depression, sleep disturbances, quality of life, and both positive and negative emotions were found.Conclusion: Our results suggest that PS128TM has the distinct advantage of providing stress relief and can improve mental health for people with a high-stress job. Future placebo-controlled studies are warranted to explore the effect and underlying mechanisms of action of PS128TM.Clinical Trial Registration:https://clinicaltrials.gov/ (identifier: NCT04452253-sub-project 2).
The Role of CD276 in Cancers
Authors: Liu Shengzhuo , Liang Jiayu , Liu Zhihong , Zhang Chi , Wang Yang , Watson Alice Helen , Zhou Chuan , Zhang Fan , Wu Kan , Zhang Fuxun , Lu Yiping , Wang Xianding 
Published: March 2021

ObjectiveAberrant expression of the immune checkpoint molecule, CD276, also known as B7-H3, is associated with tumorigenesis. In this review, we aim to comprehensively describe the role of CD276 in malignancies and its potential therapeutic effect.Data SourcesDatabase including PubMed, EMbase, Cochrane Library, CNKI, and Clinical Trails.gov were searched for eligible studies and reviews. Study selection: Original studies and review articles on the topic of CD276 in tumors were retrieved.ResultsCD276 is an immune checkpoint molecule in the epithelial mesenchymal transition (EMT) pathway. In this review, we evaluated the available evidence on the expression and regulation of CD276. We also assessed the role of CD276 within the immune micro-environment, effect on tumor progression, and the potential therapeutic effect of CD276 targeted therapy for malignancies.ConclusionCD276 plays an essential role in cell proliferation, invasion, and migration in malignancies. Results from most recent studies indicate CD276 could be a promising therapeutic target for malignant tumors.
Monte Carlo Comparison of Proton and Helium-ion Minibeam Generation Techniques
Authors: Schneider Tim , De Marzi Ludovic , Patriarca Annalisa , Prezado Yolanda 
Published: March 2021

Proton minibeam radiation therapy (pMBRT) is a novel therapeutic strategy that combines the normal tissue sparing of submillimetric, spatially fractionated beams with the improved dose deposition of protons. In contrast to conventional approaches which work with comparatively large beam diameters (5 mm to several centimetres) producing laterally homogeneous fields, pMBRT uses submillimetric minibeams to create a distinct spatial modulation of the dose featuring alternating regions of high dose (peaks) and low dose (valleys). This spatial fractionation can increase the tolerance of normal tissue and may allow a safe dose escalation in the tumour. Important quantities in this context are the valley dose as well as the peak-to-valley dose ratio (PVDR). Creating submillimetric proton beams for clinical applications is a challenging task that until now has been realized with mechanical collimators (metal blocks with thin slits or holes). However, this method is inherently inefficient, inflexible and creates undesirable secondary neutrons. We therefore recently proposed a method for obtaining clinical minibeams using only magnetic focusing. In this study, we performed Monte Carlo simulations in order to compare minibeams generated using the new method of magnetic focusing with two techniques involving mechanical collimators (collimator and broad beam irradiation, collimator and pencil beam scanning). The dose deposition in water was simulated and dosimetric aspects [beam broadening, depth-dose profiles, PVDR and Bragg-peak-to-entrance dose ratio (BEDR)] as well as irradiation efficiencies were evaluated. Apart from protons, we also considered helium ions which, due to their reduced lateral scattering and sharper Bragg peak, may present a promising alternative for minibeam radiation therapy. Magnetically focused minibeams exhibited a 20–60 times higher PVDR than mechanically collimated minibeams and yielded an increase in irradiation efficiency of up to two orders of magnitude. Compared to proton minibeams, helium ion minibeams were found to broaden at a slower rate and yield an even higher PVDR (at the same minibeam spacing) as well as a more favourable BEDR. Moreover, the simulations showed that methods developed for proton minibeams are suitable for the generation of helium ion minibeams.
Workers' Decisions to Disclose a Mental Health Issue to Managers and the Consequences
Authors: Dewa Carolyn S. , van Weeghel Jaap , Joosen Margot C. W. , Gronholm Petra C. , Brouwers Evelien P. M. 
Published: March 2021

Background: Stigma can be a barrier to accessing effective interventions and work accommodations for mental illnesses. Fear of stigma's concomitant prejudice and discrimination can inhibit workers from asking for help. Thus, it may be important to develop effective interventions addressing workplace stigma. To identify important targets for these interventions, this study addresses three questions: (1) what proportion of workers experiencing mental health issues disclosed their mental health issue to their managers, (2) what factors did they identify as contributing to their disclosure decisions, and (3) what were the consequences of their decisions?Methods: The dataset is comprised of responses from respondents who were randomly drawn from a nationally representative sample of working Dutch adults who completed a web-based survey in February 2018. Respondents indicating they either had or have mental health issues were asked three sets of questions focusing on: (1) Did you disclose your mental health issue to you manager? (2) For what reasons did you disclose/not disclose the issue? (3) What were the consequences of your disclosure decision?Results: About 73% of respondents with lived experience with mental health issues told their managers about their mental health issue. The structure of the survey questions identified four groups of workers who either: (1) disclosed and had a positive experience (64.2%), (2) disclosed and had a negative experience (9.0%), (3) did not disclose and had a positive experience (22.6%), or (4) did not disclose and had a negative experience (4.2%).Conclusion: Our results reflect workers' diverse preferences for disclosing their mental health issues to their managers. Understanding both the factors that contributed to the decision to disclose and the consequences of disclosure decisions could help to better target workplace educational programs and interventions to address workplace stigma. Our findings suggest that addressing workplace stigma may not be as straightforward as requiring all employees to receive anti-stigma education. Rather, education should support workers to make the appropriate disclosure decision based on their workplace contexts. Future research is needed to understand the optimal ways for workers struggling with mental health issues to ask and receive help if they need it.
Probiotics, Pre-biotics and Synbiotics in the Treatment of Pre-diabetes: A Systematic Review of Randomized Controlled Trials
Authors: Wang Xian , Yang Jiao , Qiu Xianliang , Wen Qing , Liu Min , Zhou Dongqi , Chen Qiu 
Published: March 2021

Objectives: This study aimed to review the data from randomized controlled trials (RCTs) and identify evidence for microbiota's role and use of probiotics, pre-biotics, or synbiotics in pre-diabetes.Methods: RCTs of pro-, pre-, synbiotics for the treatment of pre-diabetes population will be summarized. We searched for EMBASE, MEDLINE, Web of Science, Cochrane Central, Clinical Trials (ClinicalTrials.gov) from inception to February 2021.Results: The gut microbiota influences host metabolic disorders via the modulation of metabolites, including short-chain fatty acids (SCFAs), the endotoxin lipopolysaccharides (LPS), bile acids (BA) and trimethylamine N-oxide (TMAO), as well as mediating the interaction between the gastrointestinal system and other organs. Due to the limited sources of studies, inconsistent outcomes between included studies. Probiotics can decrease glycated hemoglobin (HbA1c) and have the potential to improve post-load glucose levels. The supplementation of probiotics can suppress the rise of blood cholesterol, but the improvement cannot be verified. Pre-biotics are failed to show an evident improvement in glycemic control, but their use caused the changes in the composition of gut microbiota. A combination of probiotics and pre-biotics in the synbiotics supplementation is more effective than probiotics alone in glycemic control.Conclusion: In the current studies using probiotics, pre-biotics or synbiotics for the treatment of pre-diabetes, the benefits of modulating the abundance of gut microbiota were partially demonstrated. However, there is insufficient evidence to show significant benefits on glucose metabolism, lipid metabolism and body composition.
Duration of Static and Dynamic Periods of the Upper Arm During Daily Life of Manual Wheelchair Users and Matched Able-Bodied Participants: A Preliminary Report
Authors: Goodwin Brianna M. , Jahanian Omid , Cain Stephen M. , Van Straaten Meegan G. , Fortune Emma , Morrow Melissa M. 
Published: March 2021

Background: Manual wheelchair (MWC) users with spinal cord injuries (SCI) are at a significantly higher risk of experiencing rotator cuff pathology than able-bodied individuals. A deeper understanding of where the arm is used dynamically within the humeral workspace during daily life may help explain why MWC users have higher shoulder pathology rates than able-bodied individuals. The purpose of this study was to report the daily percentage and consecutive durations MWC users and matched able-bodied individuals (controls) spent static and dynamic across the humeral elevation workspace.Methods: MWC users with SCI and controls wore three inertial measurement units on their bilateral arms and torso for 1 or 2 days. The percentages of time and average consecutive duration individuals were static or dynamic while in five humeral elevation ranges (0–30°, 30–60°, 60–90°, 90–120°, and &gt;120°) were calculated and compared between cohorts.Results: Forty-four MWC users (10 females, age: 42.8 ± 12.0, time since injury: 12.3 ± 11.5) and 44 age- and sex-matched controls were enrolled. The MWC cohort spent significantly more time dynamic in 60–90° (p = 0.039) and 90–120° (p = 0.029) and had longer consecutive dynamic periods in 30–60° (p = 0.001), 60–90° (p = 0.027), and 90–120° (p = 0.043) on the dominant arm. The controls spent significantly more time dynamic in 0–30° of humeral elevation (p &lt; 0.001) on both arms. Although the average consecutive static durations were comparable between cohorts across all humeral elevation ranges, the MWC cohort spent a significantly higher percentage of their day static in 30–60° of humeral elevation than controls (dominant: p = 0.001, non-dominant: p = 0.01). The MWC cohort had a moderate association of increased age with decreased time dynamic in 30–60° for both arms.Discussion: Remote data capture of arm use during daily life can aid in understanding how arm function relates to shoulder pathology that follows SCI and subsequent MWC use. MWC users spent more time dynamic in higher elevations than controls, and with age, dynamic arm use decreased in the 30–60° humeral elevation range. These results may exemplify effects of performing activities from a seated position and of age on mobility.
Sisplatinin Neden Olduğu Nefrotoksisite Ve Ultrastrüktürel Hasar Üzerine Kurkuminin Koruyucu Etkisi
Authors: BİRİNCİ Hülya , ŞEN HALICIOĞLU Büşra , ÖZTATLICI Mustafa , YÜNCÜ Mehmet 
Published: March 2021

Giriş ve Amaç: Antineoplastik bir ajan olan sisplatinin önemli yan etkilerinden biri de nefrotoksisitedir. Sisplatin böbrek genel yapısının bozulmasına ve fonksiyon kaybına sebep olur. Böbrekte glomerüler filtrasyonun düşmesine, serum kreatininin yükselmesine, serum potasyum ve magnezyum seviyelerinin düşmesine ve iskemik-nekrotik hasara yol açmaktadır. Kurkuminin, antioksidan, antifibrojenik, antikanserojenik ve antiinflamatuvar özellikleri vardır. Bu çalışmada, sıçanlarda, sisplatinin böbreklerde yaptığı hasara karşı kurkuminin koruyucu etkisinin araştırılması amaçlandı.
Gereç ve Yöntemler: Wistar albino cinsi 26 erişkin sıçan 4 gruba ayrıldı. Kontrol grubuna 6 gün boyunca DMSO intraperitoneal (i.p.) olarak verildi. Sisplatin grubuna 3. gün 20 mg/kg sisplatin i.p. olarak tek doz uygulandı. Kurkumin grubuna 6 gün boyunca günde 200 mg/kg kurkumin i.p. olarak verildi. Sisplatin +kurkumin grubuna 6 gün boyunca günde 200 mg/kg kurkumin ve 3. gün tek doz 20 mg/kg sisplatin i.p. olarak verildi. Sıçanlar 7. gün sakrifiye edildi. Alınan böbrek dokularında ışık ve elektron mikroskopik değerlendirmelerin yanı sıra biyokimyasal analizler yapıldı.
Bulgular: Yalnızca kurkumin verdiğimiz grupta herhangi bir hasar yoktu ve kontrol grubundakilere benzerdi. Sisplatin verilen grupta ise renal kortekste konjesyon, intraselüler kastlar ve tübüler nekroz izlendi. Ancak kurkumin+sisplatin grubunda bu hasarlar azaldı ve dokudaki genel hücre organizasyonunun normale yakın olduğu gözlendi.
Sonuç: Sisplatinin neden olduğu nefrotoksisiteye karşı kurkuminin koruyucu bir ajan olabileceği önerilmektedir.
FAKTOR RISIKO YANG BERHUBUNGAN DENGAN KEJADIAN ASMA BRONKIALE PADA ANAK USIA 5-12 TAHUN
Authors: Hamdan Hamdan , Musniati Nia 
Published: March 2021

Asma merupakan golongan penyakit yang sulit disembuhkan. Penyakit yang mengenai saluran pernafasan ini sangat mengganggu kualitas para penderitanya. Penderita asma akan merasakan keterbatasan aktifitas baik ringan, sedang maupun berat tergantung pada derajat asma yang dideritanya. Prevalensi asma di Indonesia untuk daerah pedesaan 4,3% dan perkotaan 6,5% dan prevalensi penyakit asma di Provinsi Jawa Tengah tahun 2007 adalah 3%. Tujuan penelitian ini mengetahui beberapa faktor risiko yang berhubungan dengan kejadian asma bronkial pada anak usia 5-12 tahun di Balai Kesehatan Paru Masyarakat (BKPM) Wilayah Salatiga. Jenis penelitian ini menggunakan desain kasus kontrol. Populasi dalam penelitian ini adalah 15 penderita asma bronkial pada anak usia 5-12 tahun sebagai (kasus) dan 15 yang tidak menderita asma bronkial pada anak usia 5-12 tahun sebagai (kontrol) di BKPM Salatiga.yang datang berobat pada bulan November tahun 2012 sampai Bulan Januari tahun 2013 sehingga jumlah 30 populasi. Analisis data yang digunakan adalah analisis Univariat dan Bivariat. Hasil penelitian menunjukkan terdapat hubungan bermakna antara kejadian asma bronkiale pada anak usia 5-12 tahun di BKPM Kota Salatiga dengan kepemilikan binatang peliharaan (p value =0,043), paparan asap rokok (p value =0,001) dan riwayat asma bronkiale (p value=0,000).
Pemerolehan Fonologi Bahasa Indonesia Anak Laki-Laki Usia 4 (Empat) Tahun
Authors: Fitriana Riri Amanda 
Published: March 2021

Penelitian ini bertujuan untuk mendeskripsikan pemerolehan fonologi berupa pemerolehan vokal, konsonan, dan diftong. Metode dalam penelitian ini adalah metode kualitatif dengan pendekatan studi kasus yang diperoleh seorang laki-laki berusia 4 tahun. Pada penelitian ini ditemukan bahwa IHA (kepanjangannya) telah memperoleh fonem vokal lengkap di usia 4 (empat) tahun dan sebagian besar bunyi konsonan juga telah diperoleh. Bunyi vokal rangkap atau diftong juga telah ia kuasai. Sementara bunyi frikatif [f], bunyi getar [r] belum dikuasainya sampai usia 4 (empat) tahun. Uniknya, IHA memiliki pola tersendiri jika menemukan konsonan /l/ dan konsonan /r/ yang terletak pada akhir kata. IHA akan menggantinya dengan fonem //ŋ//. Ini terjadi karena speech motor yang IHA miliki belum lengkap atau belum berkembang dengan sempurna
Upaya Meningkatkan Hasil Belajar Gerak Dasar Lompat Jauh Gaya Menggantung dengan Menggunakan Alat Bantu Kotak Kardus
Authors: Prastowo Martinus Handoko 
Published: March 2021

Tujuan penelitian ini adalah untuk meningkatkan prestasi cabang olahraga lompat jauh gaya menggantung melalui penggunaan alat bantu kotak kardus, pembelajaran pada siswa kelas VI SDN Kanung 02 kecamatan Sawahan kabupaten Madiun tahun pelajaran 2019/2020. Penelitian ini menggunakan metode Penelitian Tindakan Kelas (PTK). Teknik analisis data yang digunakan adalah deskriptif kuantitatif. Prosedur penelitian adalah dengan menentukan langkah-langkah dalam melaksanakan penelitian. Adapun langkah-langkah pelaksanaan PTK secara prosedurnya adalah dilaksanakan secara partisipatif atau kolaborasi (guru, PJOK lainnya) bekerjasama, mulai dari tahap orientasi dilanjutkan penyusunan rencana tindakan dilanjutkan pelaksanaan tindakan dalam siklus I, diskusi yang bersifat analitik yang kemudian dilanjutkan kepada langkah refleksi-evaluatif atas kegiatan yang dilakukan pada siklus I, untuk kemudian mempersiapkan rencana modifikasi, koreksi, atau pembetulan, atau penyempurnaan pada siklus II dan seterusnya. Hasil penelitian menunjukkan bahwa dengan menggunakan alat bantu pembelajaran dapat meningkatkan hasil belajar gerak dasar lompat jauh gaya menggantung dari pra siklus ke siklus I dan dari siklus I ke siklus II. Hasil belajar lompat jauh gaya menggantung pada pra siklus dalam kategori tuntas adalah 33,3% atau 6 siswa, pada akhir siklus I setelah diberikan pembelajaran teknik gerak dasar lompat jauh gaya menggantung menggunakan alat bantu kardus meningkat menjadi 55,55% atau 10 siswa, kemudian kembali terjadi peningkatan setelah diberikan tindakan pada siklus II menjadi 88,88% atau 16 siswa dengan lebih menekankan memperbanyak kesempatan siswa dalam melakukan gerakan lompat jauh secara keseluruhan. Simpulan penelitian ini adalah penggunakan alat bantu pembelajaran dapat meningkatkan hasil belajar gerak dasar lompat jauh gaya menggantung pada siswa kelas VI SDN Kanung 02 tahun pelajaran 2019/2020.
Interpolated Hadith (Rules and regulations)
Authors: Najim Dr.Fariz Abdallah Hasan , As'ad Abdelhadi Dr. Mohammed Kamel 
Published: March 2021

This research tackled and important subject, and that is the interpolated Hadith. This importance appears from the fact that the interpolated Hadith is one of the weak (daif) or defective hadith (moutal) .The interpolated is considered one of the reasons of defectiveness. The science of defectiveness as it is known is considered one of the must exact and difficult science of hadith. It is the top of the exact critical approach among the scholars of hadith. Therefore this research came to disclose to us all what is related to the interpolated Hadith. It also came with exact and pure scientific benefits. It shall - if god’s will - not be necessary to refer to its various resources, to reap its fruits and to harvest its flowers
The role of quantitative models in geography
Authors: Aziz Assist.prof .Huda Abdel Kader , Kader Aziz S.A Haifaa Abdel 
Published: March 2021

The aim of this research is to highlight the importance of quantitative trends and statistical methods in geographies because of Based on the data of the General Company for the manufacture of grain for the quantity of rice production and the years of production and for the years (2009-2015), it was used to find the estimated and predictive value until 2020.Using two methods of analysis of comparative costs and assessing the qualitative factors determining the optimal location of the company's silates have been determined The best location is the Karbala silo in the first way, and the best location according to the method of assessing the factors was to Silo Hilla
The Role Of The Teacher In Enhancing Social Responsibility At High School Stage
Authors: Riwan Dr. Saud Abbas 
Published: March 2021

The current research aimed at identifying The role of the teacher in enhancing social responsibility at the students according to following fields ( concern , understanding and participation ) in accordance with all sample , gender ( male , female ) , besides difference indication regarding the role of the teacher in enhancing social responsibility at the students according to following fields (concern, understanding and participation) basing of gender variable .The researcher adopted a scale to measure the role of the teacher in enhancing social responsibility at the students of high school stage , consisted of ( 34) paragraphs , distributed into three fields (concern - with 10 paragraphs for measurement , understanding- 12 paragraphs for measurement and participation – with 12 paragraphs for measurement .This scale was applied to a sample of the teachers , amount of (100) teachers from both genders in halves .After statistic processing of obtained data from the sample , we reached to the following results:

Weak teacher role in enhancing social responsibility at the students of high school stage in fields of ( concern , understanding and participation ) .

There is differences with statistic indication in enhancing social responsibility at the students of high school stage according to gender variable as the difference was for the favor of females teachers