bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Inguinal Hernia
Authors: Aiolfi Alberto , Cavalli Marta , Ferraro Simona Del , Manfredini Livia , Bonitta Gianluca , Bruni Piero Giovanni , Bona Davide , Campanelli Giampiero 
Published: January 2021

Background:
Despite the advent of innovative surgical platforms and operative techniques, a definitive indication of the best surgical option for the treatment of unilateral primary inguinal hernia remains unsettled. Purpose was to perform an updated and comprehensive evaluation within the major approaches to inguinal hernia.

Methods:
Systematic review and network meta-analyses of randomized controlled trials (RCTs) compare Lichtenstein tension-free repair, laparoscopic transabdominal preperitoneal (TAPP) repair, and totally extraperitoneal repair (TEP). Risk ratio (RR) and weighted mean difference (WMD) were used as pooled effect size measures, whereas 95% credible intervals (CrI) were used to assess relative inference.

Results:
Thirty-five RCTs (7777 patients) were included. Overall, 3496 (44.9%) underwent Lichtenstein, 1269 (16.3%) TAPP, and 3012 (38.8%) TEP repair. The Visual Analogue Scale (VAS) was significantly lower for minimally invasive repair at <12 hours, 24 hours, and 48 hours. Postoperative chronic pain [TAPP vs Lichtenstein (RR = 0.36; 95% CrI 0.15–0.81) and TEP vs Lichtenstein (RR = 0.36; 95% CrI 0.21–0.54)] and return to work/activities [TAPP vs Lichtenstein (WMD = −3.3; 95% CrI −4.9 to −1.8) and TEP vs Lichtenstein (WMD = −3.6; 95% CrI −4.9 to −2.4)] were significantly reduced for minimally invasive approaches. Wound hematoma and infection were significantly reduced for minimally invasive approaches, whereas no differences were found for seroma, hernia recurrence, and hospital length of stay.

Conclusions:
Minimally invasive TAPP and TEP repair seem associated with significantly reduced early postoperative pain, return to work/activities, chronic pain, hematoma, and wound infection compared to the Lichtenstein tension-free repair. Hernia recurrence, seroma, and hospital length of stay seem similar across treatments.
Helping individuals with firearm injuries: A cluster randomized trial
Authors: Lyons Vivian H. , Floyd Anthony S. , Griffin Elizabeth , Wang Jin , Hajat Anjum , Carone Marco , Benkeser David , Whiteside Lauren K. , Haggerty Kevin P. , Rivara Frederick P. , Rowhani-Rahbar Ali 
Published: January 2021

BACKGROUND
Patients with firearm injuries are at high risk of subsequent arrest and injury following hospital discharge. We sought to evaluate the effect of a 6-month joint hospital- and community-based low-intensity intervention on risk of arrest and injury among patients with firearm injuries.

METHODS
We conducted a cluster randomized controlled trial, enrolling patients with firearm injuries who received treatment at Harborview Medical Center, the level 1 trauma center in Seattle, Washington, were 18 years or older at the time of injury, spoke English, were able to provide consent and a method of contact, and lived in one of the five study counties. The intervention consisted of hospital-based motivational interviewing, followed by a 6-month community-based intervention, and multiagency support. The primary outcome was the risk of subsequent arrest. The main secondary outcome was the risk of death or subsequent injury requiring treatment in the emergency department or hospitalization.

RESULTS
Neither assignment to or engagement with the intervention, defined as having at least 1 contact point with the support specialist, was associated with risk of arrest at 2 years post–hospital discharge (relative risk for intervention assignment, 1.15; 95% confidence interval, 0.90–1.48; relative risk for intervention engagement, 1.07; 95% confidence interval, 0.74–2.19). There was similarly no association observed for subsequent injury.

CONCLUSIONS
This study represents one of the first randomized controlled trials of a joint hospital- and community-based intervention delivered exclusively among patients with firearm injuries. The intervention was not associated with changes in risk of arrest or injury, a finding most likely due to the low intensity of the program.

LEVEL OF EVIDENCE
Care management, level II.
Outcomes of same admission cholecystectomy and endoscopic retrograde cholangiopancreatography for common bile duct stones: A post hoc analysis of an Eastern Association for the Surgery of Trauma multicenter study
Authors: Tracy Brett M. , Paterson Cameron W. , Kwon Eugenia , Mlaver Eli , Mendoza April , Gaitanidis Apostolos , Rattan Rishi , Mulder Michelle B. , Yeh D. Dante , Gelbard Rondi B. ,   on behalf of the EAST Retained Common Bile Duct Stones Study Group
Published: January 2021

BACKGROUND
The optimal timing for cholecystectomy after endoscopic retrograde cholangiopancreatography (ERCP) for common bile duct (CBD) stones is unknown. We hypothesized that a delay between procedures would correlate with more biliary complications and longer hospitalizations.

METHODS
We prospectively identified patients who underwent same admission cholecystectomy after ERCP for CBD stones from 2016 to 2019 at 12 US medical centers. The cohort was stratified by time between ERCP and cholecystectomy: ≤24 hours (immediate), >24 to ≤72 hours (early), and >72 hours (late). Primary outcomes included operative duration, postoperative length of stay, (LOS), and hospital LOS. Secondary outcomes included rates of open conversion, CBD explorations, biliary complications, and in-hospital complications.

RESULTS
For the 349 patients comprising the study cohort, 33.8% (n = 118) were categorized as immediate, 50.4% (n = 176) as early, and 15.8% (n = 55) as late. Rates of CBD explorations were lower in the immediate group compared with the late group (0.9% vs. 9.1%, p = 0.01). Rates of open conversion were lower in the immediate group compared with the early group (0.9% vs. 10.8%, p < 0.01) and in the immediate group compared with the late group (0.9% vs. 10.9%, p < 0.001). On a mixed-model regression analysis, an immediate cholecystectomy was associated with a significant reduction in postoperative LOS (β = 0.79; 95% confidence interval, 0.65–0.96; p = 0.02) and hospital LOS (β = 0.68; 95% confidence interval, 0.62–0.75; p < 0.0001).

CONCLUSION
An immediate cholecystectomy following ERCP correlates with a shorter postoperative LOS and hospital LOS. Rates of CBD explorations and conversion to open appear more common after 24 hours.

LEVEL OF EVIDENCE
Therapeutic, level III.
Real-time bedside management and titration of partial resuscitative endovascular balloon occlusion of the aorta without an arterial line: Good for pressure, not for flow!
Authors: Carr Matthew J. , Benham Derek A. , Lee Joseph J. , Calvo Richard Y. , Wessels Lyndsey E. , Schrader Andrew J. , Krzyzaniak Michael J. , Martin Matthew J. 
Published: January 2021

BACKGROUND
Partial resuscitative endovascular balloon occlusion of the aorta (pREBOA) attempts to minimize ischemia/reperfusion injury while controlling hemorrhage. There are little data on optimal methods to evaluate and titrate partial flow, which typically requires invasive arterial line monitoring. We sought to examine the use of a miniaturized handheld digital pressure device (COMPASS; Mirador Biomedical, Seattle, WA) for pREBOA placement and titration of flow.

METHODS
Ten swine underwent standardized hemorrhagic shock. Carotid and iliac pressures were monitored with both arterial line and COMPASS devices, and flow was monitored by aortic and superior mesenteric artery flow probes. Partial resuscitative endovascular balloon occlusion of the aorta was inflated to control hemorrhage for 15 minutes before being deflated to try targeting aortic flow of 0.7 L/min (using only the COMPASS device) by an operator blinded to the arterial line pressures and aortic flow. Correlations between COMPASS and proximal/distal arterial line were evaluated, as well as actual aortic flow.

RESULTS
There was strong correlation between the distal mean arterial pressure (MAP) and the distal COMPASS MAP (r = 0.979, p < 0.01), as well as between the proximal arterial line and the proximal COMPASS on the pREBOA (r = 0.989, p < 0.01). There was a significant but weaker correlation between the distal compass MAP reading and aortic flow (r = 0.47, p < 0.0001), although it was not clinically significant and predicted flow was not achieved in a majority of the procedures. Of 10 pigs, survival times ranged from 10 to 120 minutes, with a mean survival of 50 minutes, and 1 pig surviving to 120 minutes.

CONCLUSION
Highly reliable pressure monitoring is achieved proximally and distally without arterial lines using the COMPASS device on the pREBOA. Despite accurate readings, distal MAPs were a poor indicator of aortic flow, and titration based upon distal MAPs did not provide reliable results. Further investigation will be required to find a suitable proxy for targeting specific aortic flow levels using pREBOA.
Teprotumumab in Clinical Practice: Recommendations and Considerations From the OPTIC Trial Investigators
Authors: Douglas Raymond S. , Wang Yao , Dailey Roger A. , Harris Gerald J. , Wester Sara T. , Schiffman Jade S. , Tang Rosa A. , Fowler Brian , Fleming James , Smith Terry J. 
Published: January 2021

Background:
Thyroid eye disease (TED) is a vision-threatening and debilitating condition that until very recently had no Food and Drug Administration (FDA)-approved medical therapies. Teprotumumab has recently been approved to treat TED. We aim to provide guidance for its use, based on the input of the US investigators who participated in Phase 2 and Phase 3 clinical trials.

Methods:
An expert panel was convened on October 11th and November 16th of 2019. All panel members had extensive experience as investigators in the Phase 2 and/or Phase 3 clinical trials of teprotumumab. Consensus among those investigators was reached to determine patient characteristics most appropriate for teprotumumab treatment. Safety guidelines were also reviewed and agreed on.

Results:
The authors recommend that teprotumumab be considered first-line therapy for patients with clinically significant ophthalmopathy, including those with disease duration exceeding 9 months. The clinical activity score (CAS) may be useful for longitudinal monitoring but should not be used to determine treatment eligibility. Criteria will likely be expanded after more experience with the drug. Using teprotumumab for patients with TED with substantial signs, symptoms, or morbidity without a CAS score of >4 (e.g., progressive proptosis, diplopia, and early compressive optic neuropathy) or more, could be considered. Diabetes mellitus and inflammatory bowel disease comorbidities should not be exclusionary, but stringent monitoring in these patients is recommended. Drug dosing, administration interval, and duration should adhere to the study protocol: 8 infusions, separated by 3 weeks. Patients with more severe disease may benefit from additional doses. Corticosteroids can be used before or during teprotumumab therapy. Clinical and laboratory monitoring should be consistent with good clinical practice for patients receiving teprotumumab.

Conclusions:
Confirming the efficacy of teprotumumab usage outside the narrow parameters of the completed clinical trials will require rigorous scientific validation. As a step in that direction, we believe its on-label usage is appropriately applied to all patients with TED with substantial symptoms or morbidity, as judged by their physician.
Neuro-Ophthalmic Manifestations of Mollaret Meningitis
Authors: Park Benjamin , Harish Bindiganavile Shruthi , Nakawah Mohammad O. , Bhat Nita , Lee Andrew G. 
Published: January 2021

Abstract:
Mollaret meningitis (MM) refers to benign recurrent aseptic meningitis usually following herpes simplex virus 2 (HSV-2) infection. Neuro-ophthalmic manifestations associated with MM are rarely reported. We present a case of recurrent HSV-2 meningitis with the neuro-ophthalmic presentation of papilledema and sixth nerve palsy. To our knowledge, this is the first such description in the English language ophthalmic literature.
Introducing the 24-2C Visual Field Test in Neuro-Ophthalmology
Authors: Yamane Maya L. M. , Odel Jeffrey G. 
Published: January 2021

Purpose:
The Humphrey 24-2C visual field test is a modified 24-2 visual field test that incorporates 10 additional test points in the central 10° of vision. This study compares the new 24-2C test to the standard Humphrey 10-2 visual field test in patients presenting for neuro-ophthalmology evaluation to evaluate its ability to detect central visual field defects.

Methods:
Twenty-five neuro-ophthalmology patients (42 eyes) underwent both 24-2C and 10-2 visual field testing using the Humphrey perimeter. The number of flagged total deviation (TD) and pattern deviation (PD) points of the 10 added test points of the 24-2C were compared with the corresponding 10-2 fields at the P < 5%, P < 2%, and P < 1% significance levels. The total number of flagged TD points were further analyzed by diagnosis. An experienced neuro-ophthalmologist evaluated all visual fields, commenting on the added value for clinical practice.

Results:
There was no significant difference between the number of flagged TD and PD points of the 10 extra 24-2C points and corresponding 10-2 points at all significance levels. When analyzed by diagnosis, there was no significant difference in the number of flagged TD points in patients with optic neuritis, ischemic optic neuropathy, optic atrophy, and no neuro-ophthalmic disease. The added 24-2C points aided in identifying visual field defects and areas of spared central vision and had similar diagnostic value as the 10-2.

Conclusions:
The 24-2C is able to detect visual field loss in the central 10° that corroborates with loss detected in the 10-2 pattern. The 24-2C exhibits potential to be used as a hybrid between the 24-2 and 10-2 to better evaluate visual field defects.
Management of a Complex Peristomal Fistula
Authors: Zhu Li-Bo , Sun Jia-nan , Cong Yue , Wang Ting , Hu Jieman , Hu Hai-yan 
Published: January 2021

BACKGROUND:
We describe our experiences caring for a patient with a peristomal fistula (PF), characterized by suppuration from a peristomal abscess. The challenges associated with this case included management of a complex fistula and prevention of abdominal necrotizing fasciitis and peritonitis.

CASE:
A 63-year-old man presented with severe peristomal swelling and pain resulting from an abscess adjacent to his ileostomy. He was malnourished and depressed. He underwent a low anterior resection (Dixon procedure) for rectal cancer 2 years ago and an abdominoperineal resection (Miles procedure) for the recurrence of rectal carcinoma 1 year later. In addition, he underwent bowel resection with the creation of an ileostomy due to intestinal obstruction caused by a second recurrence approximately 1 month prior to this admission. Following evaluation of the fistula anatomy, incision and drainage of the abscess was performed. Diversion of the effluent was used to control infection and promote fistula closure. A registered dietitian and a psychologist were consulted to optimize nutrition and treat his depression. After 20 days of treatment, the patient recovered and was safely discharged.

CONCLUSION:
Peristomal fistula management should include anatomical assessment, incision and drainage of the abscess, diversion to control effluent, and skin protection. For complex cases, the coordinated efforts of the interdisciplinary team are imperative.
A robot chamfering system for special-shaped and thin-walled workpieces
Authors: Li Mingyang , Du Zhijiang , Ma Xiaoxing , Dong Wei , Wang Yongzhi , Gao Yongzhuo , Chen Wei 
Published: January 2021

Purpose
This paper aims to propose a robotic automation system for processing special-shaped thin-walled workpieces, which includes a measurement part and a processing part.

Design/methodology/approach
In the measurement part, to efficiently and accurately realize the three-dimensional camera hand-eye calibration based on a large amount of measurement data, this paper improves the traditional probabilistic method. To solve the problem of time-consuming in the extraction of point cloud features, this paper proposes a point cloud feature extraction method based on seed points. In the processing part, the authors design a new type of chamfering tool. During the process, the robot adopts admittance control to perform compensation according to the feedback of four sensors mounted on the tool.

Findings
Experiments show that the proposed system can make the tool smoothly fit the chamfered edge during processing and the machined chamfer meets the processing requirements of 0.5 × 0.5 to 0.9 × 0.9 mm2.

Practical implications
The proposed design and approach can be applied on many types of special-shaped thin-walled parts. This will give a new solution for the automation integration problem in aerospace manufacturing.

Originality/value
A novel robotic automation system for processing special-shaped thin-walled workpieces is proposed and a new type of chamfering tool is designed. Furthermore, a more accurate probabilistic hand-eye calibration method and a more efficient point cloud extraction method are proposed, which are suitable for this system when comparing with the traditional methods.
Synthesis analysis for multi-UAVs formation anomaly detection
Authors: Jianhong Wang , Yanxiang Wang 
Published: January 2021

Purpose
The purpose of this paper is to deal with the anomaly detection problem in multi-unmanned aerial vehicles (UAVs) formation that can be transformed to identify some unknown parameters; a more general nonlinear dynamical model for each UAV is considered to include two terms. Due to an unknown parameter corresponding to the normal or abnormal state for each UAV, the bias-compensated approach is proposed to obtain the unbiased parameter estimation. Meanwhile, the biased error and accuracy analysis are also given in case of strict statistical description of the uncertainty or white noise. To relax this strict statistical description on external noise, an analytic center approach is proposed to identify the unknown parameters in presence of bounded noise, such that two inner and outer ellipsoidal approximations are constructed to include the membership set. To be precise, this paper is regarded as one extension and summary for the author’s previous research on the anomaly detection in multi-UAV formation. Finally, one simulation example is given to confirm the theoretical results.

Design/methodology/approach
Firstly, one extended nonlinear relation is constructed to embody the mutual relationship of UAVs. Secondly, to obtain the unbiased parameter estimations, the bias-compensated approach is applied to achieve it under the condition of white noise. Thirdly, in case of unknown but bounded noise, an analytic center approach is proposed to deal with this special case. Without loss of generality, the author thinks this paper can be used as one extension and summary for research on multi-UAVs formation anomaly detection.

Findings
An anomaly detection problem in multi-UAVs formation can be transformed into a problem of nonlinear system identification, and in modeling the nonlinear dynamical model for each UAV, two terms are considered simultaneously to embody the mutual relationships with other nearest UAV.

Originality/value
To the best knowledge of the authors, this problem of the anomaly detection problem in multi-UAVs formation is proposed by the authors’ previous work, and the problem of multi-UAVs formation anomaly detection can be transferred into one problem of parameter identification. In case of unknown but bounded noise, an analytic center approach is proposed to identify the unknown parameters, which correspond to achieve the goal of the anomaly detection.
“If more people cut out gluten, the zombies would wake up”: the construction of health-related concerns by gluten-free food consumers
Authors: Wei ML 
Published: January 2021

PurposeMarkets for free from foods have undergone extensive growth as consumers attempt to manage their health in increasingly novel ways. This research explores the making of consumer perceptions about the health of gluten-free foods.Design/methodology/approachThis research employs qualitative methods including in-depth interviews with consumers of gluten-free foods and content analysis of online consumer comments.FindingsFindings illustrate how consumers leverage personal responsibility, social commentary and political criticism in ways that forge essential connections with traditional medical authority. In particular, consumers blend diverse views together by expressing reverence, positioning complementarity and framing temporality.Research limitations/implicationsThis research highlights the productive role of consumers in shaping what constitutes health-related concerns and widens the scope of explanatory factors beyond product- and individual-level differences. This research is set in the context of gluten-free foods and draws on interview data from a single set of consumers. Future research could consider other free from markets including, for example, soy-free foods and corn-free foods, both of which implicate some of the most common ingredients in food products and potential regional differences both within and outside of North America.Practical implicationsThis research offers insights into the marketing of gluten-free foods and free from foods in general, specifically the participation of consumers in legitimising the need for these foods on the basis of health.Originality/valueI weave together multiple streams of work across disciplines including food marketing, contested illnesses and institutional logics to further our understanding of the dynamic nature of contemporary markets for free from foods.
Curvilinear relationship between experienced incivility and nontask behavior in Korean companies
Authors: Song Gi Ryung , Kim Kyoung Seok 
Published: January 2021

PurposeMost existing studies treat the relationship between experienced incivility and behavioral responses as linear. However, the current study examines the curvilinear relationships between experienced incivility and organizational citizenship behavior (OCB) and instigated incivility using conservation of resources (COR) theory and by referring to related studies that have identified typical positive and negative employee nontask behaviors. Furthermore, this study identifies turnover intention as a moderator of these curvilinear relationships.Design/methodology/approachAll samples were obtained from respondents working for Korean companies listed on the Korean Securities Dealers Automated Quotations (KOSDAQ); 228 samples were used for the analysis. A quadratic regression function was established to analyze the curved relationships according to hierarchical stages.FindingsOur analysis determined that aU-shaped curvilinear relationship exists between experienced incivility and OCB, and an invertedU-shaped curvilinear relationship exists between experienced and instigated incivility. However, the moderating effect of turnover intention is significant only in the relationship between experienced and instigated incivility.Originality/valueThis study exhibits three points of originality—first, by simultaneously considering two dependent variables as responses to experienced incivility and examining their response patterns; second, by using a curvilinear relationship model to investigate the relationship between experienced incivility and its dependent variables; and finally, by finding a moderator to the curved relationship.