bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Metabolites in Chinese Autistic Children: A Multi-Center Study Based on Urinary 1H-NMR Metabolomics Analysis
Authors: Ma Yu , Zhou Hao , Li Chunpei , Zou Xiaobing , Luo Xuerong , Wu Lijie , Li Tingyu , Chen Xiang , Mao Meng , Huang Yi , Li Erzhen , An Yanpeng , Zhang Lili , Wang Tianqi , Xu Xiu , Yan Weili , Jiang Yonghui , Wang Yi 
Published: May 2021

Background: Autism spectrum disorder (ASD) is a group of early-onset neurodevelopmental disorders. However, there is no valuable biomarker for the early diagnosis of ASD. Our large-scale and multi-center study aims to identify metabolic variations between ASD and healthy children and to investigate differential metabolites and associated pathogenic mechanisms.Methods: One hundred and seventeen autistic children and 119 healthy children were recruited from research centers of 7 cities. Urine samples were assayed by 1H-NMR metabolomics analysis to detect metabolic variations. Multivariate statistical analysis, including principal component analysis (PCA), and orthogonal projection to latent structure discriminant analysis (OPLS-DA), as well as univariate analysis were used to assess differential metabolites between the ASD and control groups. The differential metabolites were further analyzed by receiver operating characteristics (ROC) curve analysis and metabolic pathways analysis.Results: Compared with the control group, the ASD group showed higher levels of glycine, guanidinoacetic acid, creatine, hydroxyphenylacetylglycine, phenylacetylglycine, and formate and lower levels of 3-aminoisobutanoic acid, alanine, taurine, creatinine, hypoxanthine, and N-methylnicotinamide. ROC curve showed relatively significant diagnostic values for hypoxanthine [area under the curve (AUC) = 0.657, 95% CI 0.588 to 0.726], creatinine (AUC = 0.639, 95% CI 0.569 to 0.709), creatine (AUC = 0.623, 95% CI 0.552 to 0.694), N-methylnicotinamide (AUC = 0.595, 95% CI 0.523 to 0.668), and guanidinoacetic acid (AUC = 0.574, 95% CI 0.501 to 0.647) in the ASD group. Combining the metabolites creatine, creatinine and hypoxanthine, the AUC of the ROC curve reached 0.720 (95% CI 0.659 to 0.777). Significantly altered metabolite pathways associated with differential metabolites were glycine, serine and threonine metabolism, arginine and proline metabolism, and taurine and hypotaurine metabolism.Conclusions: Urinary amino acid metabolites were significantly altered in children with ASD. Amino acid metabolic pathways might play important roles in the pathogenic mechanisms of ASD.
Galectin-3 Binding Protein, Depression, and Younger Age Were Independently Associated With Alexithymia in Adult Patients With Type 1 Diabetes
Authors: Melin Eva O. , Svensson Ralph , Dereke Jonatan , Hillman Magnus 
Published: May 2021

Aims:Alexithymia has been linked to cardiovascular disease. The aim was to explore whether the immuno-inflammatory variables galectin-3 binding protein (Gal3BP), soluble (s)CD163 and galectin-3 were independently associated with alexithymia, while controlling for known risk factors for cardiovascular disease, such as depression, anxiety, impaired glycemic control, obesity, smoking, and physical inactivity in patients with type 1 diabetes (T1D).Methods:Cross-sectional design. The participants were consecutively recruited from one diabetes out-patient clinic. Alexithymia, depression and anxiety were assessed by self-report instruments. Blood samples, anthropometrics, and blood pressure were collected, supplemented with data from electronic health records. High Gal3BP was defined as ≥3.3 μg/ml, high sCD163 as ≥0.6 μg/ml, high galectin-3 as ≥2.6 ng/ml, impaired glycemic control as HbA1c &gt;70 mmol/mol (&gt;8.6%) and abdominal obesity as waist circumference ≥ 1.02 m for men and ≥ 0.88 m for women.Results:Two hundred and ninety two patients participated (men 56%, aged 18–59 years, alexithymia prevalence 15%). Patients with alexithymia had higher prevalence of depression (34 vs. 6%,p&lt; 0.001), anxiety (61 vs. 30%,p&lt; 0.001), high Gal3BP levels (39 vs. 17%,p= 0.004), high HbA1c levels (46 vs. 24%,p= 0.006), and abdominal obesity (29 vs. 15%,p= 0.045). Depression [adjusted odds ratio (AOR) 6.5, p&lt; 0.001], high Gal3BP levels (AOR 2.4,p= 0.035), and age (AOR 0.96,p= 0.027) were independently associated with alexithymia. Abdominal obesity (AOR 4.0,p&lt; 0.001), high Gal3BP levels (AOR 2.8,p= 0.002), and depression (AOR 2.9,p= 0.014) were associated with high HbA1c. Abdominal obesity and anxiety were associated [Crude odds ratio (COR) 2.4,p= 0.006].Conclusions:T1D patients with alexithymia had higher prevalence of high Gal3BP levels, depression, impaired glycemic control, anxiety, and abdominal obesity, which are known risk factors for cardiovascular disease. Only high Gal3BP levels, depression, and younger age were independently associated with alexithymia in adult patients with T1D.
Mental Health Help-Seeking and Associated Factors Among Public Health Workers During the COVID-19 Outbreak in China
Authors: She Rui , Wang Xiaohui , Zhang Zhoubin , Li Jinghua , Xu Jingdong , You Hua , Li Yan , Liang Yuan , Li Shan , Ma Lina , Wang Xinran , Chen Xiuyuan , Zhou Peien , Lau Joseph , Hao Yuantao , Zhou Huan , Gu Jing 
Published: May 2021

Background: The COVID-19 outbreak in China has created multiple stressors that threaten individuals' mental health, especially among public health workers (PHW) who are devoted to COVID-19 control and prevention work. This study aimed to investigate the prevalence of mental help-seeking and associated factors among PHW using Andersen's Behavioral Model of Health Services Use (BMHSU).Methods: A cross-sectional survey was conducted among 9,475 PHW in five provinces across China between February 18 and March 1, 2020. The subsample data of those who reported probable mental health problems were analyzed for this report (n = 3,417). Logistic and hierarchical regression analyses were conducted to examine the associations of predisposing, enabling, need, and COVID-19 contextual factors with mental health help-seeking.Results: Only 12.7% of PHW reported professional mental help-seeking during the COVID-19 outbreak. PHW who were older, had more days of overnight work, received psychological training, perceived a higher level of support from the society, had depression and anxiety were more likely to report mental help-seeking (ORm range: 1.02–1.73, all p &lt; 0.05) while those worked in Centers for Disease Control and Prevention were less likely to seek help (ORm = 0.57, p &lt; 0.01). The belief that mental health issues were not the priority (64.4%), lack of time (56.4%), and shortage of psychologists (32.7%) were the most frequently endorsed reasons for not seeking help.Conclusions: The application of BMHSU confirmed associations between some factors and PHW's mental health help-seeking. Effective interventions are warranted to promote mental health help-seeking of PHW to ameliorate the negative impact of mental illness and facilitate personal recovery and routine work.
The Micro Hand S vs. da Vinci Surgical Robot-Assisted Surgery on Total Mesorectal Excision: Short-Term Outcomes Using Propensity Score Matching Analysis
Authors: Zeng Yijia , Wang Guohui , Li Zheng , Lin Hao , Zhu Shaihong , Yi Bo 
Published: May 2021

Objective: To compare the operation mode and clinical short-term outcomes of the Micro Hand S and the da Vinci surgical robot, we chose total mesorectal excision (TME) as the standard procedure for its good reflection of robot-assisted surgery advantages.Methods: We collected a total of 54 consecutive patients who underwent robot-assisted TME by two surgical robots from January 2016 to October 2020. We used propensity score matching (PSM) to create balanced cohorts of Micro Hand S group (n = 14) and da Vinci group (n = 14). Robotic installation and operation time, hospital and surgery costs, and intraoperative and postoperative clinical outcomes were compared.Results: In terms of robotic installation time, the Micro Hand S robot took longer than the da Vinci robot (24.2 ± 9.4 min vs. 17.1 ± 5.1 min, P &lt; 0.05). As for the costs, the Micro Hand S group had lower total hospital costs (87,040.1 ± 24,676.9 yuan vs. 125,292.3 ± 17,706.7 yuan, P &lt; 0.05) and surgery costs (25,772.3 ± 4,117.0 yuan vs. 46,940.9 ± 10,199.7 yuan, P &lt; 0.05) than the da Vinci group. There were no statistically significant differences (P &gt; 0.05) in other indicators, including total operation time, robotic operation time, blood loss, time to first liquid diet, time of getting out of bed, and hospital stay.Conclusion: The Micro Hand S enables patients with rectal cancer to enjoy lower medical costs of robotic surgery.Clinical Trial Registration:ClinicalTrials.gov [NCT02752698]
Análisis de los intereses moratorios en una empresa constructora
Authors: Gardi Melgarejo Victoria , Arroyo Osorio Gerardo , Moreno Rodríguez Rosa Ysabel 
Published: May 2021

El estudio se realizó con el objetivo de estudiar los elementos que inciden en el pago de los intereses moratorios, por lo cual es transcendental que las áreas implicadas en la práctica administrativa y financiera, posean el conocimiento contable y tributario. La investigación se desarrolla bajo el enfoque cualitativo, se hizo la recopilación de datos a través de las entrevistas a 5 trabajadores, con la respectiva guía de entrevista compuesta por seis preguntas alineadas a las sub categorías, permitiendo obtener una idea más amplia y más objetiva referente a los diferentes procesos que desarrolla la entidad, y mejorando factores claves que permiten que los efectos sean más precisos y concisos, luego se realizó la triangulación de los datos con el apoyo del software Atlas ti 8, en los resultados se pudo considerar que tanto los tributos, contraprestaciones con el estado y las sanciones administrativas inciden de forma directa en el pago de los intereses moratorios, en el sentido de que, cada impuesto que no era abonado genera intereses moratorios por día, así como había impuestos con multas por no ser abonadas, esto sucedía a menudo en la empresa constructora por la falta de preparación del colaborador del área de administración y finanzas, y la inadecuada comunicación entre las áreas implicadas, la importancia de no considerar el pago de estos impuestos en sus flujos.
Capacidades Organizacionales en las Empresas de Manufacturas de Cuenca – Ecuador
Authors: Mejía Matute Silvia Raquel , Pinos Luzuriaga Luis Gabriel , Proaño Rivera Wazhington Bladimir , García Galarza Erika Belén 
Published: May 2021

La industria de manufacturas en el Ecuador debe enfrentar el reto de ser más competitiva incrementando su productividad, lo cual requiere una organización empresarial capaz de gestionar eficazmente los recursos, los procesos, y obtener resultados que le permitan aprender y evolucionar. Para ello, se requiere conocer la organización empresarial interna que permita proponer estrategias. Entonces, la pregunta es: ¿cuáles son las principales características de las capacidades organizacionales de las empresas manufactureras de Cuenca? Para responder a esta pregunta se aplicó una encuesta utilizando el método probabilístico para determinar la muestra. Se analizaron los datos utilizando estadísticas descriptivas como el método de diferencias y el método de componentes principales para establecer categorías de las capacidades organizativas. Se obtuvo que las empresas manufactureras de Cuenca en promedio le dan un valor de 86.5 % a sus capacidades organizativas y son las grandes las que presentan mayores fortalezas. Los recursos humanos y tecnológicos son importantes en las empresas, pero no suficientes para construir capacidades en las organizaciones, se requiere de coordinación, gestión y control para mantener operativa una tecnología, ampliar los mercados, responder a estrategias para mejorar la producción y disminuir los costos.
Reconstruction of a Genome-Scale Metabolic Model of Streptomyces albus J1074: Improved Engineering Strategies in Natural Product Synthesis
Authors: Kittikunapong Cheewin , Ye Suhui , Magadán-Corpas Patricia , Pérez-Valero Álvaro , Villar Claudio J. , Lombó Felipe , Kerkhoven Eduard J. 
Published: May 2021

Streptomyces albus J1074 is recognized as an effective host for heterologous production of natural products. Its fast growth and efficient genetic toolbox due to a naturally minimized genome have contributed towards its advantage in expressing biosynthetic pathways for a diverse repertoire of products such as antibiotics and flavonoids. In order to develop precise model-driven engineering strategies for de novo production of natural products, a genome-scale metabolic model (GEM) was reconstructed for the microorganism based on protein homology to model species Streptomyces coelicolor while drawing annotated data from databases and literature for further curation. To demonstrate its capabilities, the Salb-GEM was used to predict overexpression targets for desirable compounds using flux scanning with enforced objective function (FSEOF). Salb-GEM was also utilized to investigate the effect of a minimized genome on metabolic gene essentialities in comparison to another Streptomyces species, S. coelicolor.
Plasmonic resonant modes in highly symmetric multi-branches sea-urchin like nanostructures
Authors: Chen Yu-Yu , Lin Chia-Yi , Su Yu-Lun , Chang Shih-hui Gilbert 
Published: May 2021

Abstract
The electrostatic charge distribution model and the finite-difference time-domain method were used to provide a physically intuitive interpretation of how the shape and the number of branches affect the localized surface plasmon resonances of 3D sea-urchin like nanoparticles. We consider both planner and spherical structures with pins of cylindrical, triangular and hexagonal shape. Better alignment between surface charges of opposite sign leads to higher resonant energy states. More pin numbers provide more surface distribution area to spread dipole charges which leads to worse charges alignment and redshift of dipole mode. However, as the pin number increases, the quadrupole surface charge was pushed toward the pin tip due to Coulomb repulsion. Better charge alignment caused the quadrupole blueshift. Other effects such as convex and concave shape and dielectric materials are also discussed. Our finding may provide a designing rule to synthesize multi-branch nanoparticles for bio-chemical sensing applications.
Rapid and accurate identification of colon cancer by Raman spectroscopy coupled with convolutional neural networks
Authors: Wu Xingda , Li Shaoxin , Xu Qiuyan , Yan Xinliang , Fu Qiuyue , Fu Xinxin , Fang Xianglin , Zhang Yanjiao 
Published: May 2021

Abstract
Colonoscopy is regarded as the gold standard in colorectal tumor diagnosis, but it is costly and time-consuming. Raman spectroscopy has shown promise for differentiating cancerous from non-cancerous tissue and is expected to be a new tool for oncological diagnosis. However, traditional Raman spectroscopy analysis requires tedious preprocessing, and the classification accuracy needs to be improved. In this work, a novel Raman spectral qualitative classification method based on convolutional neural network (CNN) is proposed for the identification of three different colon tissue samples, including adenomatous polyp, adenocarcinoma and normal tissues. Experimental results show that this CNN model has superior feature extraction ability. For the spectral data of new individuals, the trained CNN model presents much better classification performance than traditional machine learning methods, such as the k-nearest neighbor, random forest, and support vector machine. Raman spectroscopy combined with CNN can be used as an effective auxiliary tool for the early diagnosis of colon cancer.
Sztuka gry na instrumentach klawiszowych początku XV wieku a średniowieczna mnemotechnika
Authors: Lubieniecki Ryszard 
Published: May 2021

Sztuka gry na instrumentach klawiszowych stanowi dziedzinę muzyczną, w której szczególnie wyraźne wydaje się „zawieszenie” pomiędzy tradycją ustną a piśmienną. Autor umieszcza ars organica początku XV w. w kontekście kultury opartej na pamięci oraz nakreśla wynikające z tej perspektywy konsekwencje dla badania i postrzegania zachowanego repertuaru muzycznego. Podstawowy materiał źródłowy stanowią dwa anonimowe traktaty organowe: Octo principalia de arte organisandi i Opusculum de arte organica, pochodzące z rękopisu M.CIII, przechowywanego w Bibliotece Kapituły Metropolitalnej w Pradze.
W pierwszej części artykułu autor analizuje konstrukcję praskich traktatów organowych z perspektywy funkcjonowania średniowiecznej memorii. Wskazuje na zabiegi mnemotechniczne, takie jak stosowanie porządków numerycznych, informacji wydzielonych słowem nota (łac. „zanotuj”, „zapamiętaj”) oraz zabiegów perswazyjnych.
Druga część poświęcona została kwestiom dotyczących bezpośrednio praktyki gry na instrumentach klawiszowych. Najpierw przedstawione zostają podstawowe modele melodyczno-rytmiczne (tactus) z odniesieniem do zachowanego repertuaru muzycznego (Kodeksu z Faenzy oraz źródeł fragmentarycznych, m.in. praskich fragmentów organowych). Analizy (dokonane już wcześniej przez wielu innych autorów) wykazują zbieżność figur tactus zawartych w traktatach z zachowanymi tabulaturami organowymi. Następnie konstrukcja traktatu Opusculum de arte organica skojarzona zostaje z teorią improwizacji Jeffa Pressinga oraz z perspektywy kształtowania muzycznego procesu w improwizacji porównane zostają ze sobą dwie kompozycje: Kyrie Magne Deus z praskich fragmentów organowych (CZ-Pnm 1D a 3/52, recto) oraz Kyrie Cunctipotens genitor Deus z Kodeksu z Faenzy (I-Fz MS 117, fol. 79r–79v). Na podstawie tego zestawienia autor podkreśla znaczenie niezbędnego w improwizacji „przyswojenia” podstawowych modeli melodycznych, a tym samym zwraca uwagę na fizjologiczny aspekt gry na instrumencie, obecny w znaczeniu słowa tactus (łac. „dotyk”, „zmysł dotyku). Artykuł zamykają uwagi dotyczące mnemotechniki oraz związanym z nią problemem indywidualizmu średniowiecznego twórcy.
A Structure Hierarchy for the Aluminofluoride Minerals
Authors: Hawthorne Frank C. , Herwig Sasha 
Published: May 2021

ABSTRACTThe structure hierarchy hypothesis states that structures may be ordered hierarchically according to the polymerization of coordination polyhedra of higher bond-valence, and such hierarchies are useful in understanding the general compositional, structural, and paragenetic variations within the structural group of interest. Here we develop a structure hierarchy for the aluminofluoride minerals based on the polymerization of the dominant (AlΦ6) octahedra and their linkage with other strongly bonded complex anionic groups. The minerals are divided first into the following categories: (1) simple aluminofluorides and (2) compound aluminofluorides containing other oxyanions. The minerals are then ordered according to the polymerization of the constituent polyhedra into a coherent structural hierarchy. The chemical composition and crystal-chemical details of the ions of the interstitial complex are a collective function of the Lewis acidity of the interstitial cations; the presence of interstitial anions, both simple [F–, (OH)–] and complex [(SO4)2–]; self-polymerization of the (AlF6)3– octahedra; and polymerization with both Mg(F,OH)6 octahedra and other complex anions: (SO4)2–, (PO4)3–, (CO3)2–.
Minimal interplay between explicit knowledge, dynamics of learning and temporal expectations in different, complex uni- and multisensory contexts
Authors: Ball Felix , Spuerck Inga , Noesselt Toemme 
Published: May 2021

AbstractWhile temporal expectations (TE) generally improve reactions to temporally predictable events, it remains unknown how the learning of temporal regularities (one time point more likely than another time point) and explicit knowledge about temporal regularities contribute to performance improvements; and whether any contributions generalise across modalities. Here, participants discriminated the frequency of diverging auditory, visual or audio-visual targets embedded in auditory, visual or audio-visual distractor sequences. Temporal regularities were manipulated run-wise (early vs. late target within sequence). Behavioural performance (accuracy, RT) plus measures from a computational learning model all suggest that learning of temporal regularities occurred but did not generalise across modalities, and that dynamics of learning (size of TE effect across runs) and explicit knowledge have little to no effect on the strength of TE. Remarkably, explicit knowledge affects performance—if at all—in a context-dependent manner: Only under complex task regimes (here, unknown target modality) might it partially help to resolve response conflict while it is lowering performance in less complex environments.
Discovery of an Edge-on Circumstellar Debris Disk around BD+45° 598: A Newly Identified Member of the β Pictoris Moving Group
Authors: Hinkley Sasha , Matthews Elisabeth C. , Lefevre Charlène , Lestrade Jean-Francois , Kennedy Grant , Mawet Dimitri , Stapelfeldt Karl R. , Ray Shrishmoy , Mamajek Eric , Bowler Brendan P. , Wilner David , Williams Jonathan , Ansdell Megan , Wyatt Mark , Lau Alexis , Phillips Mark W. , Fernandez Jorge , Gagné Jonathan , Bubb Emma , Sutlieff Ben J. , Wilson Thomas J. G. , Matthews Brenda , Ngo Henry , Piskorz Danielle , Crepp Justin R. , Gonzalez Erica , Mann Andrew W. , Mace Gregory 
Published: May 2021

Abstract
We report the discovery of a circumstellar debris disk viewed nearly edge-on and associated with the young, K1 star BD+45° 598 using high-contrast imaging at 2.2 μm obtained at the W.M. Keck Observatory. We detect the disk in scattered light with a peak significance of ∼5σ over three epochs, and our best-fit model of the disk is an almost edge-on ∼70 au ring, with inclination angle ∼87°. Using the NOEMA interferometer at the Plateau de Bure Observatory operating at 1.3 mm, we find resolved continuum emission aligned with the ring structure seen in the 2.2 μm images. We estimate a fractional infrared luminosity of L
IR/L
tot

× 10−4, higher than that of the debris disk around AU Mic. Several characteristics of BD+45° 598, such as its galactic space motion, placement in a color–magnitude diagram, and strong presence of lithium, are all consistent with its membership in the β Pictoris Moving Group with an age of 23 ± 3 Myr. However, the galactic position for BD+45° 598 is slightly discrepant from previously known members of the β Pictoris Moving Group, possibly indicating an extension of members of this moving group to distances of at least 70 pc. BD+45° 598 appears to be an example from a population of young circumstellar debris systems associated with newly identified members of young moving groups that can be imaged in scattered light, key objects for mapping out the early evolution of planetary systems from ∼10–100 Myr. This target will also be ideal for northern-hemisphere, high-contrast imaging platforms to search for self-luminous, planetary mass companions residing in this system.