bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAM162A is Crucial for Mitochondrial Structure, Dynamics, and Bioenergetics, Driving Cellular Protection and Longevity
Authors: Matamoros Andrea , Soffia Juan Pablo , Muñoz Marcelo , Maturana Michael , Gonzalez-Ibañez Alvaro , Gomez-Lillo Gabriela , Astorga Cesar , Ruiz Lina M. , Jorquera Ramón , Elorza Alvaro A. 
Published: December 2024

AbstractIntroductionFAM162A is a mitochondrial protein evolutionarily conserved across taxa and ubiquitously expressed in various tissues. It is known for its role in hypoxia-induced apoptosis. However, paradoxically, FAM162A is overexpressed in cancer, where its pro-apoptotic function seems overridden, suggesting an alternative role associated with mitochondrial function and cell survival. Additionally, its precise localization and topology remain controversial.ObjectivesTo assess the role of FAM162A in mitochondrial structure, dynamics, and bioenergetics and its impact on cell viability, while establishing its precise localization, orientation, and topology. Additionally, to generate a transgenic Drosophila model overexpressing human FAM162A to evaluate its effects on organismal survival under normal and stress conditions.MethodsLocalization, orientation, and topology were determined by protease protection assays in COS7 cells. Loss-and gain-of-function experiments were performed to assess mitochondrial function and turnover by confocal microscopy, immunoblots and Seahorse technology. A transgenic Drosophila model overexpressing human FAM162A was generated to evaluate organismal survival under normal and stress conditions.ResultsFAM162A is essential for maintaining mitochondrial ultrastructure and bioenergetics, thereby influencing cell viability and stress resistance. Localization studies revealed that FAM162A resides predominantly in the inner mitochondrial membrane, particularly within the cristae, where it modulates the fusion protein OPA1. Transgenic Drosophila overexpressing human FAM162A exhibited increased lifespan and locomotor activity under both normal and heat stress conditions.ConclusionFAM162A emerges as a crucial player in maintaining mitochondrial integrity and bioenergetics. Its functional role, potentially mediated through interaction with OPA1, impacts mitochondrial health, stress resistance, cellular viability, and organismal longevity.
Sub-second characterization of locomotor activities of mouse models of Parkinsonism
Authors: Berezhnoi Daniil , Chehade Hiba Douja , Simms Gabriel , Chen Liqiang , Chu Hong-Yuan 
Published: December 2024

SummaryThe degeneration of midbrain dopamine (DA) neurons disrupts the neural control of natural behavior, such as walking, posture, and gait in Parkinson’s disease. While some aspects of motor symptoms can be managed by dopamine replacement therapies, others respond poorly. Recent advancements in machine learning-based technologies offer opportunities for unbiased segmentation and quantification of natural behavior in both healthy and diseased states. In the present study, we applied the motion sequencing (MoSeq) platform to study the spontaneous locomotor activities of neurotoxin and genetic mouse models of Parkinsonism as the midbrain DA neurons progressively degenerate. We also evaluated the treatment efficacy of levodopa (L-DOPA) on behavioral modules at fine time scales. We revealed robust changes in the kinematics and usage of the behavioral modules that encode spontaneous locomotor activity. Further analysis demonstrates that fast behavioral modules with higher velocities were more vulnerable to loss of DA and preferentially affected at early stages of Parkinsonism. Last, L-DOPA effectively improved the velocity, but not the usage and transition probability, of behavioral modules of Parkinsonian animals. In conclusion, the hypokinetic phenotypes in Parkinsonism are mediated by the decreased velocities of behavioral modules and the disrupted temporal organization of sub-second modules into actions. Moreover, we showed that the therapeutic effect of L-DOPA is mainly mediated by its effect on the velocities of behavior modules at fine time scales. This work documents robust changes in the velocity, usage, and temporal organization of behavioral modules and their responsiveness to dopaminergic treatment under the Parkinsonian state.
Relationship Between Circulating FGF21 and Physiological and Lifestyle Characteristics, an Exploratory Study
Authors: Peterson Matthew , Adair Kathleen , Funderburk LesLee 
Published: December 2024

Fibroblast growth factor 21 (FGF21) is a biomarker that has been linked to metabolic health. This study was conducted to examine the relationship between FGF21 and its purported upstream regulators and downstream targets in healthy humans. Male and female participants completed three study visits. During visit 1 anthropometrics were measured and a VO2peaktest was conducted on a stationary bike. During visits 2 and 3 resting metabolic rate, heart rate, and blood pressure were recorded and a blood sample was taken. Results from visits 2 and 3 were averaged before statistical analysis. Additionally, participants completed a food frequency questionnaire to detail typical diet over the previous month and had three days of measured physical activity and sleep. Moderate correlations between FGF21 and measured sleep (r= 0.34,p= 0.05), saturated fat intake (r= −0.37,p= 0.04), and blood urea nitrogen levels (r= −0.47,p= 0.01) were observed. Additionally, greater intensities of daily physical activity were associated with lower FGF21 levels. Serum FGF21 levels may be influenced by lifestyle variables such as sleep and physical activity, diet, and other circulating biomarkers.Highlights-FGF21 is positively correlated with sleep in healthy humans.-Sugar intake is positively correlated with FGF21 concentrations in humans.-Blood urea nitrogen concentrations are negatively correlated with FGF21 in humans.
BIM framework to minimize embodied energy in heritage buildings: old downtown Amman case studies
Authors: Al-Zrigat Zaid.M. 
Published: December 2024

Purpose
This paper aims to develop an integrated Building Information Modeling (BIM) framework to minimize embodied energy (EE) in heritage buildings. Focusing on Darat al Funun and the Chief British Representative’s Building (CBR) in Old Downtown Amman, the study addresses the critical need for a comprehensive lifecycle energy evaluation of building materials in heritage structures. Recognizing EE’s significant role in the sustainability of heritage buildings, the framework systematically incorporates the principles of ISO 14040 to assess and reduce EE, ensuring methodological accuracy and enhancing the preservation and energy efficiency of these culturally significant structures.

Design/methodology/approach
The research employs a multi-step approach grounded in ISO 14040 principles to ensure methodological rigor in lifecycle analysis. It integrates BIM with Life Cycle Assessment (LCA), utilizing Extraction, Transformation, and Loading (ETL) technologies for data interoperability. Detailed models of Darat al Funun and the CBR buildings are developed using Autodesk Revit. Spatial ETL via the Feature Manipulation Engine (FME) integrates diverse data sources. The Google Maps API facilitates mapping and visualization, while Power Pivot conducts advanced data analysis, evaluating EE across building materials’ lifecycles in alignment with ISO 14040 standards.

Findings
Applying the prototype to Darat al Funun and CBR buildings assesses EE parameters. Results demonstrate that using local materials effectively reduces EE. The study underscores the impacts of transportation, capacity utilization and material lifespan in EE assessment. The framework integrates BIM for comprehensive energy evaluations, advocates eco-efficient materials and supports sustainable supply chain practices.

Originality/value
This study innovates by applying BIM to minimize EE in heritage buildings, an often-neglected area in prior research. Unlike earlier works that integrated BIM with LCA, this research uniquely tailors the integration to address heritage buildings’ specific challenges – preservation, energy conservation and structural integrity. Incorporating criteria such as historical value, material conservation and site-specific energy patterns, the study adapts modern tools for sustainable heritage conservation. This nuanced approach contributes novel insights to BIM and enhances sustainability in heritage building practices, emphasizing EE’s crucial role in preserving cultural heritage.
Metaverse and education: identifying key themes and future research trajectories
Authors: Virani Shreya , Rautela Sonica 
Published: December 2024

PurposeThe present study aims to undertake an extensive review of scholarly literature by exploring the intersection of the metaverse and education.Design/methodology/approachThe researchers used the relevant documents from the Scopus database to conduct bibliometric analysis. The data were retrieved from 2010 to February 2024. Citation, co-citation and author’s keyword analysis were conducted for bibliometric analysis. The study was performed using VOSviewer and the Biblioshiny app software packages.FindingsThe extant literature related to the metaverse and education is presented in the paper. The paper identified four key themes in the literature, i.e. Metaverse and education, Contemporary application of metaverse: a multisectoral perspective, Metaverse: spatial dimensions and concerns and Metaverse: shaping the future of digital interaction. Other information related to the most influential authors, journals and countries concerning metaverse and education is also presented.Originality/valueThe paper studies the gradual evolution of the present research domain over time. The study outlines key areas that have emerged from the literature review, suggesting directions for future research.
Formal versus casual: examining the influence of doctors’ profile pictures on patients’ choice in the online health market
Authors: Yang Hualong , Cheng Zhiying , Zhou Junjie 
Published: December 2024

PurposeThe online profile picture of a doctor serves as a pivotal source of visual information, playing a key role in shaping the doctor’s professionalism in the online health market. Doctors can strategically curate the elements of their online profile pictures, such as attire and background, to either reinforce a formal image or craft a casual image, thereby influencing patients’ doctor choices. Despite this, the relative effectiveness of formal or casual images in swaying patient choices remains unclear. This study endeavors to bridge this knowledge gap.Design/methodology/approachThis study tested the influence of a doctor’s attire and background in their profile picture on patient decision-making, with a focus on discerning variations in impact among patient groups differentiated by the severity of their illnesses (i.e. high-severity versus low-severity conditions). We formulated four hypotheses and tested them through an econometric analysis and a controlled laboratory experiment.FindingsThe empirical findings reveal that doctors’ formal profile pictures, characterized by formal attire and backgrounds, exert a more pronounced influence on patient choices than casual images. The severity of a patient’s illness positively moderated the relationship between formal images and patient choices.Originality/valueThese insights make a significant contribution to the understanding of patient behavior in selecting doctors within the online health market. Furthermore, they offer valuable guidance for doctors in optimizing their online profile presentation to better align with patient preferences and expectations.
Using accounting measures and data envelopment analysis to measure firm performance: the effect of variability in prices
Authors: Cui Claire Murong , Harrison Julie A. , Ng Frederick , Rouse Paul 
Published: December 2024

Purpose
Recent accounting research using data envelopment analysis (DEA) measures firm performance using accounting measures from annual reports, which are readily available from electronic databases (e.g. Demerjian et al., 2013; Schwab, 2022). This approach differs from conventional DEA studies that analyse productivity and use internal data about physical quantities of production inputs and outputs. Using accounting measures instead of physical measures presents challenges as accounting measures aggregate physical quantities using unknown but fluctuating prices. This raises the issue of what these DEA models measure. This study aims to examine how price variability influences DEA results when measuring firm performance and identifies implications for future accounting research.

Design/methodology/approach
This study uses a Cobb–Douglas function to simulate physical data for input and output quantities, which are then priced to form accounting measures that incorporate different levels of price variability. These simulated accounting data are used to estimate DEA results. The results using physical data and accounting data are compared to identify the impact of increasing levels of price variation and sample size on the comparability of DEA results.

Findings
The study confirms the theoretical argument that accounting measures can be used in DEA to measure productivity when prices are identical across a sample of firms. Moreover, where price variability is low, large samples can also reliably estimate productivity when using accounting measures. This measure of productivity fundamentally underpins financial performance and provides a new dimension of firm performance that can be measured by accounting measures. However, where price variability is high, DEA using accounting measures cannot estimate productivity and can only be used for benchmarking financial performance. In this case, DEA provides an alternative measure for financial performance, which incorporates multiple dimensions and can extend traditional financial analysis approaches by providing a more comprehensive measure.

Originality/value
Despite calls for investigation (Camanho et al., 2024; Färe et al., 2017; Zelenyuk, 2020), evidence has been scarce regarding the impact of price variability when using accounting measures in DEA. Understanding this impact is key to understanding the nature of DEA results produced using accounting measures, as this can affect the interpretation and use of those results. This study is the first to focus on the impact of price variability on accounting measures within DEA and suggests new avenues for accounting research using this performance measurement method.
Finite element analysis and experimental study on the sealing performance of low-phenyl silicone rubber sealing rings
Authors: Gao Ming , Li Dongkai , Liu Kun , Xu Shuliang , Zhao Feng , Guo Ben , Pan Anhui , Xie Xiao , Han Huanre 
Published: December 2024

PurposeThe brake pipe system was an essential braking component of the railway freight trains, but the existing E-type sealing rings had problems such as insufficient low-temperature resistance, poor heat stability and short service life. To address these issues, low-phenyl silicone rubber was prepared and tested, and the finite element analysis and experimental studies on the sealing performance of its sealing rings were carried out.Design/methodology/approachThe low-temperature resistance and thermal stability of the prepared low-phenyl silicone rubber were studied using low-temperature tensile testing, differential scanning calorimetry, dynamic thermomechanical analysis and thermogravimetric analysis. The sealing performance of the low-phenyl silicone rubber sealing ring was studied by using finite element analysis software abaqus and experiments.FindingsThe prepared low-phenyl silicone rubber sealing ring possessed excellent low-temperature resistance and thermal stability. According to the finite element analysis results, the finish of the flange sealing surface and groove outer edge should be ensured, and extrusion damage should be avoided. The sealing rings were more susceptible to damage in high compression ratio and/or low-temperature environments. When the sealing effect was ensured, a small compression ratio should be selected, and rubbers with hardness and elasticity less affected by temperature should be selected. The prepared low-phenyl silicone rubber sealing ring had zero leakage at both room temperature (RT) and −50 °C.Originality/valueThe innovation of this study is that it provides valuable data and experience for the future development of the sealing rings used in the brake pipe flange joints of the railway freight cars in China.
Team collective efficacy as a mediator of coaching leadership effects on exhaustion: a multilevel investigation
Authors: Mastrorilli Andrea , Santarpia Ferdinando Paolo , Borgogni Laura 
Published: December 2024

Purpose
Team-based work is increasing within organizations nowadays. Despite calls for differentiation between individual and team levels of analysis, research on leadership effects at multiple levels is still limited. By integrating the Conservation of Resources and Social Cognitive theories, this paper aims to analyze the relationships between coaching leadership, team collective efficacy and individual exhaustion via multilevel modeling.

Design/methodology/approach
This paper opted for an exploratory study testing a 2-2-1 multilevel mediational model, positing team collective efficacy as a key factor in mediating the relationship between coaching leadership at the team level and exhaustion at the individual level. The hypotheses were tested on a sample of 311 employees, nested in 72 teams (Msize = 5.70, SDsize = 2.82 team members) of a large Italian company that provides financial services.

Findings
Results supported the positive association between coaching leadership and team collective efficacy, which, in turn, was negatively associated with team members’ average score in exhaustion and fully mediated the effect of coaching leadership on exhaustion, even controlling for team design features (i.e. task interdependence and team virtuality). The association between coaching leadership and exhaustion was only indirect, explained by team collective efficacy.

Research limitations/implications
Because of the self-report nature of the measures and the cross-sectional nature of the data, this research results might raise problems of variance in common methods and not allow causal conclusions to be drawn. Therefore, researchers are encouraged to test the proposed propositions further.

Practical implications
This paper includes several practical implications for enhancing group efficacy beliefs, which have an impact on individual well-being within the team.

Originality/value
This paper addresses the lack of empirical findings on the multilevel nature of the relationship between coaching-based leadership, collective team effectiveness and individual exhaustion.
Wound, Pressure Ulcer, and Burn Guidelines‐5: Guidelines for the management of lower leg ulcers and varicose veins, second edition
Authors: Ito Takaaki , Kukino Ryuichi , Sarayama Yasuko , Tanioka Miki , Maekawa Takeo , Yatsushiro Hiroshi , Asai Jun , Asano Yoshihide , Abe Masatoshi , Amano Masahiro , Ikegami Ryuta , Ishii Takayuki , Isei Taiki , Isogai Zenzo , Inoue Yuji , Irisawa Ryokichi , Iwata Yohei , Otsuka Masaki , Omoto Yoichi , Kato Hiroshi , Tanizaki Hideaki , Kadono Takafumi , Kaneko Sakae , Kanoh Hiroyuki , Kawakami Tamihiro , Kawaguchi Masakazu , Kono Takeshi , Koga Monji , Kodera Masanari , Sakai Keisuke , Sakurai Eiichi , Shintani Yoichi , Tsujita Jun , Doi Naotaka , Nakanishi Takeshi , Hashimoto Akira , Hasegawa Minoru , Hayashi Masahiro , Hirosaki Kuninori , Fujita Hideki , Fujimoto Manabu , Fujiwara Hiroshi , Matsuo Koma , Madokoro Naoki , Motegi Sei‐Ichiro , Yamasaki Osamu , Yoshino Yuichiro , Le Pavoux Andres , Tachibana Takao , Ihn Hironobu 
Published: December 2024

Abstract“Wound, Pressure Ulcer, and Burn Guidelines‐5: Guidelines for the management of lower leg ulcers and varicose veins, second edition” is revised from the first edition, which was published in the Japanese Journal of Dermatology in 2011. The guidelines were drafted by the Wound, Pressure Ulcer, and Burn Guidelines Drafting Committee delegated by the Japanese Dermatological Association and intend to facilitate physicians' clinical decisions in preventing, diagnosing and management of lower leg ulcers and varicose veins. We updated all sections by collecting documents published since the publication of the first edition. In particular, we added clinical question 8 (CQ8), which addresses endovenous laser ablation for varicose veins, a procedure that became covered by the Japanese national health insurance after the writing of the first edition, and endovenous radiofrequency ablation, which became covered by national health insurance in 2014. We also rearranged the subsequent clinical question (CQs) for easier reading. While the addition of these new techniques has increased the number of options available within the treatment algorithm, differences have arisen in the indication for surgery depending on the facility performing the treatment. Therefore, these have been abbreviated.
Barriers and facilitators to caregiver comfort with health‐related social needs data collection in the pediatric clinical setting
Authors: Brown Rachel , Barouk Nadia , McPeak Katie , Fein Joel , Cullen Danielle 
Published: December 2024

AbstractObjectiveTo identify barriers and facilitators to family‐level comfort with health‐related social needs (HRSN) data collection and documentation in the pediatric clinical setting.Study Setting and DesignThis qualitative study was nested within a pragmatic randomized controlled trial on social care integration in the pediatric clinical setting. We used a hybrid random‐purposive strategy to sample 60 caregivers of pediatric patients ages 0–25 presenting at two primary care clinics and one emergency department affiliated with a large pediatric healthcare system between September 2022 and 2023. We developed an interview guide and codebook to explore caregiver experiences with and perceptions of HRSN data collection and documentation.Data Sources and Analytic SampleWe conducted semi‐structured telephone interviews in English and Spanish with 60 caregivers. Interviews were conducted until thematic saturation was achieved and were transcribed verbatim. We used thematic analysis with constant comparison to code interviews and identify emerging themes.Principal FindingsOur analysis yielded several barriers to caregiver comfort with HRSN data collection and documentation: (1) stigmatization by providers and medical staff and risk of child protective services involvement, (2) providers presuming connections between documented HRSN and medical complaints, (3) permanency of documented HRSN, (4) visibility of HRSN data by pediatric patients and caregiver proxies, and (5) fear that documented HRSN could negatively impact future insurance cost and coverage. We identified four facilitators to caregiver comfort: (1) clear communication regarding the purpose of HRSN data collection and use, (2) respect for caregiver autonomy, for example, by providing the option to decline participation, (3) training of data collection personnel to ensure privacy and compassionate care, and (4) consideration of timing within the medical visit, delaying assessment until medical concerns are addressed.ConclusionsCaregiver‐identified barriers and facilitators should be considered in clinically based HRSN data collection efforts to ensure that these programs are equitable and family‐centered.