bluuebunny/crossref_metadata_2025_split huggingface dataset:
EVALUASI KEBIJAKAN PROGRAM DANA DESA DI KECAMATAN TAEBENU KABUPATEN KUPANG PROVINSI NUSA TENGGARA TIMUR (Studi pada Desa Baumata dan Desa Bokong Kecamatan Taebenu Kabupaten Kupang)
Authors: Meirgin Yektris Killa  , Hyronimus Rowa  , Ani Martini  
Published: December 2021

Penelitian ini berjudul Evaluasi Kebijakan Program Dana Desa di Kecamatan Taebenu Kabupaten Kupang (Studi Pada Desa Baumata dan Desa Kecamatan Taebenu Kabupaten Kupang). Permasalahan terkait sumber daya yang kurang kompeten, anggaran yang ada belum terkelola dengan baik, jumlah perangkat desa terbatas, laporan pertanggungjawaban terlambat, namun sarana dan prasarana masih terbatas. Penelitian ini menggunakan teori yang dikemukakan oleh William N. Dunn tentang Evaluasi Kebijakan yang dilihat dari 6 indikator, yaitu efektivitas, efisiensi, kecukupan, pemerataan, daya tanggap dan akurasi.
Hasil penelitian menunjukkan bahwa implementasi kebijakan dana desa di Desa Baumata belum terlaksana seperti yang diharapkan, perlunya peningkatan sumber daya manusia, bertambahnya jumlah aparatur di desa dan pelaksanaan kegiatan yang terfokus pada bidang pembangunan desa dan pemberdayaan masyarakat.
TIPE-TIPE KEPENGIKUTAN PEGAWAI DINAS KESEHATAN KABUPATEN MALUKU TENGGARA PROVINSI MALUKU
Authors: Fransina Jeane Matmey  , Sadu Wasistiono  , Rossy Lambelanova  
Published: December 2021

Pegawai pada organisasi pemerintah daerah cenderung memiliki kekuasaan yang rendah dan berusaha mempertanggungjawabkan tugas-tugasnya sesuai dengan aturan dan harapan pimpinan untuk pencapaian tujuan organisasi. seperti halnya para pegawai pada Dinas Kesehatan Kabupaten Maluku Tenggara, yang bekerja tanpa menyadari mereka punya kekuatan sebagai pengikut yang dapat memiliki peran cukup besar dalam memengaruhi keputusan pemimpin, sedangkan pemimpin tidak menyadari bahwa pegawai memiliki tipe dan karakter yang berbeda-beda.
Tujuan penelitian ini adalah untuk menganalisis dan mengetahui bagaimana tipe-tipe kepengikutan pegawai pada Dinas Kesehatan Kabupaten Maluku Tenggara, faktor yang memengaruhi, serta model kepengikutan pegawai. Desain penelitian adalah kualitatif dengan tipe penelitian deskriptif.
Hasil penelitian menunjukkan bahwa pegawai pada Dinas Kesehatan Kabupaten Maluku Tenggara memiliki perbedaan tipe pengikut, berupa tipe Isolates, bystanders, participants, dan activists, yang dipengaruhi oleh konsep diri berupa persepsi positif dan negatif terhadap pemimpin maupun kondisi lingkungan, dan motivasi pegawai itu sendiri. Ketika pegawai memiliki konsep diri dengan persepsi positif dan motivasi tinggi, maka pegawai tersebut termasuk dalam tipe pengikut activists, sebaliknya, jika konsep diri dengan persepsi negatif dan kurangnya motivasi pribadi, maka pegawai tersebut termasuk tipe isolates. Konsep diri dan motivasi ini dipengaruhi oleh faktor eksternal berupa gaya kepemimpinan Kepala Dinas, sarana prasarana kantor, dan kualitas sumber daya di Dinas Kesehatan Kabupaten Maluku Tenggara.
STRATEGI PENGEMBANGAN PARIWISATA DALAM PENINGKATAN PENDAPATAN ASLI DAERAH (PAD) KOTA TERNATE PROVINSI MALUKU UTARA
Authors: Aswir Pratama  , Kusworo  , Bayi Priyono  
Published: December 2021

Fokus dari penelitian ini adalah untuk mengetahui pengembangan pariwisata yang dilaksanakan oleh Dinas Pariwisata Kota Ternate, faktor-faktor yang memengaruhi serta menentukan strategi yang sebaiknya dilakukan untuk pengembangan pariwisata di Kota Ternate. Penelitian ini menggunakan teori dari Oka A. Yoeti terkait pengembangan pariwisata serta melakukan analisis SWOT dan litmus test untuk menentukan strategi yang tepat. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Dalam mengumpulkan data, peneliti melakukan observasi, wawancara dan mengumpulkan dokumen tentang pengembangan pariwisata yang dilakukan oleh Dinas Pariwisata, serta kontribusinya terhadap Pendapatan Asli Daerah (PAD) Kota Ternate.
Hasil penelitian menunjukkan bahwa pengembangan pariwisata dalam rangka peningkatan Pendapatan Asli Daerah (PAD) belum terlaksana secara optimal. Adanya pengembangan pariwisata serta kontribusinya terkait Pendapatan Asli Daerah (PAD), akan tetapi belum mampu mencapai target. Selain itu minimnya atraksi, sarana dan prasarana, yang menyebabkan kurangnya daya tarik pada objek wisata yang dikelola oleh pemerintah. Faktor-faktor yang memengaruhi terdiri dari faktor internal dan faktor eksternal yang kemudian dilanjutkan dengan menentukan strategi yang sebaiknya dilakukan untuk keberhasilan berdasarkan analisis SWOT dan litmus test didapatkan isu sangat strategis antara lain: Mengoptimalkan fungsi dan program Dinas Pariwisata dalam pengembangan pariwisata, mengoptimalkan fungsi dan program Dinas Pariwisata dalam pengembangan pariwisata, meningkatkan sarana dan prasarana pendukung pada objek wisata yang dikelola pemerintah, mengupayakan legalitas area publik atau objek wisata baru untuk dikelola oleh pemerintah daerah.
The use of animation video on tenth-grade students’ vocabulary achievement
Authors: Dzebeq Stefany Arbella , Gunawan Agus 
Published: December 2021

Vocabulary is something that very important in learning English. Relating to vocabulary, students find that it is difficult to recognize the meaning and written form. Further, there are difficulties in reading English texts. The animation video is an interested medium which expected to help and develop students’ vocabulary achievement. The research methodology in this research is quantitative, true experimental. Further, the research design is post-test only control group design. The sampling technique applied is Cluster Random Sampling, where the samples are randomly taken from the population. There are 60 samples of students and the sample classes are divided into two classes, Experimental and Control classes. Each class with 30 students. The instrument used to collect the vocabulary achievement in form of an objective test, consisting of 30 questions. The result of data are analyzed using t–test, the researcher found that Tobserved = 13,355 is higher than Ttable = 2.000 and significant (2-tailed) 0.00 than < (lower) than Alpha 0.05 that means Ho is rejected and Ha is accepted. Based on the result, it can be concluded that there is a significant effect of using Animation Video on Ten-Grade Students’ Vocabulary Achievement at MAN 18 JAKARTA.
Evaluation of the teaching and learning in listening subject
Authors: Husain Nurlaila 
Published: December 2021

This research aims to benchmark the practice of teaching listening subject being conducted in the English Department at State University of Gorontalo against the best practices which have been based on research and sound knowledge in the world of English language. The teaching of listening is now influenced by the rise of communicative language teaching which views language teaching as giving communicative competence to learners, not only grammatical competence as the earlier view held. The participant of the research is the third-semester of the English Department in the academic year of 2019.
This present study is conducted to evaluate the teaching of listening skills in the English Department at Gorontalo State University. Evaluation in this study is to benchmark the current practice of teaching listening in the English Department of State University of Gorontaloto the research-based practice. Research finding suggests that the teaching of listening to the English Department students partly has followed methodologies proposed by Richards and Goh (2008). This study shows that in general the practice of the teaching of listening at the English Department of State University of Gorontalois based on research-based methodologies. However, there are some points that need to be improved. Since the result of the study has addressed only some of the issues in the teaching of listening, therefore, future research on other issues of listening teaching needs to be done.
Students Perceptions of the Use of English as Medium of Instruction
Authors: Ika Afiyanti Nur Rahma , Miolo Sartin T. , Badu Helena 
Published: December 2021

This study aims to explore the students’ perception of the use of English as Medium of Instruction (EMI) in teaching and learning at SMA Negeri 1 Kota Gorontalo. This explorative qualitative study employed a purposive sampling method. This study involved 112 twelve-grade students from IPA, IPS, and BAHASA majors of SMA Negeri 1 Kota Gorontalo as the subjects. This study utilized questionnaires for data collection, while the Likert Scale and Percentage Formula were performed in data analysis. The result showed that the students had positive perceptions of the three EMI types of perception: visual, auditory, and speech perception. The average results in visual, auditory, and speech perceptions were 70.96% (‘strongly agree’ category), 70.49% (‘strongly agree’ category), and 57.90% (‘agree’ category). Further study with bigger samples and different subjects is recommended since this research only focuses on students perception of the Use of EMI in Teaching and Learning at SMA Negeri 1 Kota Gorontalo.
RP-HPLC Method Development and Validation for the Estimation of Lumefantrine in Bulk Drug
Authors: Sethiya Ashish , Rathore R. P. S. 
Published: December 2021

Lumefantrine is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas. A reversed-phase high performance liquid chromatography (RP-HPLC) method was developed and validated for the estimation of lumefantrine in bulk drug. The separation was achieved on Thermo C18 analytical column (250 mm × 4.6 mm i.d., 5.0 μm) using 10mM KH2PO4: acetonitrile (pH adjust 3.0 with OPA) in the ratio 20:80 v/v as mobile phase and at a flow rate of 1.0 ml/min. Detection was carried out using a UV detector at 240nm. The total chromatographic analysis time per sample was about 6.0 min with lumefantrine eluting at retention time of about 3.225 ± 0.001min. The method was validated for accuracy, precision, specificity, linearity and sensitivity. Validation studies demonstrated that this HPLC method is simple, specific, rapid, reliable and reproducible. The standard curve was linear over the concentration range of 5-25 μg/ml with r2 close to one (0.999). The limit of detection (LOD) and limit of quantitation (LOQ) obtained for lumefantrine were 0.25 μg/ml and 0.75μg/ml respectively. The high recovery and low relative standard deviation confirm the suitability of the proposed method for the determination of lumefantrine in bulk drugs.
Analysis of Pain Manifestation and Its Management in Adults
Authors: Shoaib Muhammad , Zahoor Rehan , Latif Waqas 
Published: December 2021

Introduction: Pain is link with significant disable due mobility, avoidance of activity, falls, depression and anxiety, sleep impairment, and isolation.
Objectives: The main objective of the study is to clinically analyse the pain manifestation and its management in adults.
Methods: This cross sectional clinical audit was done in Services hospital Lahore during January 2020 till June 2020. The data was collected from a large number of patients undergoing intermediate to major surgery and thus have high analgesic requirements. Medical folders that were not available or had missing notes were excluded. The folders were requested from the Medical Records Department and reviewed by four investigators.
Results: The data was collected from 169 patients. The mean age of the patients was 38 years. Pain was assessed in 85 of the 168 patients (51%) (62 of the 110 urogynaecology patients; 23 of the 58 orthopaedic patients) and reassessed in 55 of the 85 patients (65%) who had received an initial pain assessment. The ward doctor (intern, registrar or specialist) assessed pain in 67% of the 85 patients evaluated.
Conclusion: It is concluded that a significant proportion of the pain interventions appeared to be based on the professional knowledge of the practitioner and not supported by evidence-based guidelines of pain management.
Performance of a knowledge‐based planning model for optimizing intensity‐modulated radiotherapy plans for partial breast irradiation
Authors: Frederick Amy , Roumeliotis Michael , Grendarova Petra , Quirk Sarah 
Published: December 2021

AbstractPurposeTo evaluate a knowledge‐based (KB) planning model for RapidPlan, generated using a five‐field intensity‐modulated radiotherapy (IMRT) class solution beam strategy and rigorous dosimetric constraints for accelerated partial breast irradiation (APBI).Materials and methodsThe RapidPlan model was configured using 64 APBI treatment plans and validated for 120 APBI patients who were not included in the training dataset. KB plan dosimetry was compared to clinical plan dosimetry, the clinical planning constraints, and the constraints used in phase III APBI trials. Dosimetric differences between clinical and KB plans were evaluated using paired two‐tailed Wilcoxon signed‐rank tests.ResultsKB planning was able to produce IMRT‐based APBI plans in a single optimization without manual intervention that are comparable or better than the conventionally optimized, clinical plans. Comparing KB plans to clinical plans, differences in PTV, heart, contralateral breast, and ipsilateral lung dose–volume metrics were not clinically significant. The ipsilateral breast volume receiving at least 50% of the prescription dose was statistically and clinically significantly lower in the KB plans.ConclusionKB planning for IMRT‐based APBI provides equivalent or better dosimetry compared to conventional inverse planning. This model may be reliably applied in clinical practice and could be used to transfer planning expertise to ensure consistency in APBI plan quality.
Organic Light‐Emitting Physically Unclonable Functions
Authors: Kayaci Nilgun , Ozdemir Resul , Kalay Mustafa , Kiremitler N. Burak , Usta Hakan , Onses M. Serdar 
Published: December 2021

AbstractThe development of novel physically unclonable functions (PUFs) is of growing interest and fluorescent organic semiconductors (f‐OSCs) offer unique advantages of structural versatility, solution‐processability, ease of processing, and great tuning ability of their physicochemical/optoelectronic/spectroscopic properties. The design and ambient atmosphere facile fabrication of a unique organic light‐emitting physically unclonable function (OLE‐PUF) based on a green‐emissive fluorescent oligo(p‐phenyleneethynylene) molecule is reported. The OLE‐PUFs have been prepared by one‐step, brief (5 min) thermal annealing of spin‐coated nanoscopic films (≈40 nm) at a modest temperature (170 °C), which results in efficient surface dewetting to form randomly positioned/sized hemispherical features with bright fluorescence. The random positioning of molecular domains generated the unclonable surface with excellent uniformity (0.50), uniqueness (0.49), and randomness (p > 0.01); whereas the distinctive photophysical and structural properties of the molecule created the additional security layers (fluorescence profile, excited‐state decay dynamics, Raman mapping/spectrum, and infrared spectrum) for multiplex encoding. The OLE‐PUFs on substrates of varying chemical structures, surface energies and flexibility, and direct deposition on goods via drop‐casting are demonstrated. The OLE‐PUFs immersed in water, exposed to mechanical abrasion, and read‐out repeatedly via fluorescence imaging showed great stability. These findings clearly demonstrate that rationally engineered solution‐processable f‐OSCs have a great potential to become a key player in the development of new‐generation PUFs.
Rational Design of Hydrogel Networks with Dynamic Mechanical Properties to Mimic Matrix Remodeling
Authors: Wiley Katherine L. , Sutherland Bryan P. , Ogunnaike Babatunde A. , Kloxin April M. 
Published: December 2021

AbstractEngineered hydrogels are increasingly used as extracellular matrix (ECM) surrogates for probing cell function in response to ECM remodeling events related to injury or disease (e.g., degradation followed by deposition/crosslinking). Inspired by these events, this work establishes an approach for pseudo‐reversible mechanical property modulation in synthetic hydrogels by integrating orthogonal, enzymatically triggered crosslink degradation, and light‐triggered photopolymerization stiffening. Hydrogels are formed by a photo‐initiated thiol–ene reaction between multiarm polyethylene glycol and a dually enzymatically degradable peptide linker, which incorporates a thrombin‐degradable sequence for triggered softening and a matrix metalloproteinase (MMP)‐degradable sequence for cell‐driven remodeling. Hydrogels are stiffened by photopolymerization using a flexible, MMP‐degradable polymer‐peptide conjugate and multiarm macromers, increasing the synthetic matrix crosslink density while retaining degradability. Integration of these tools enables sequential softening and stiffening inspired by matrix remodeling events within loose connective tissues (Young's modulus (E) ≈5 to 1.5 to 6 kPa with >3x ΔE). The cytocompatibility and utility of this approach is examined with breast cancer cells, where cell proliferation shows a dependence on the timing of triggered softening. This work provides innovative tools for 3D dynamic property modulation that are synthetically accessible and cell compatible.
Photothermal Conjugated Polymer Nanoparticles for Suppressing Breast Tumor Growth by Regulating TRPA1 Ion Channels
Authors: Li Boying , Ren Shuxi , Gao Dong , Li Ning , Wu Manman , Yuan Hongbo , Zhou Mei , Xing Chengfen 
Published: December 2021

AbstractCancer cells survive by relying on oxidative stress defense against the accumulation of reactive oxygen species (ROS) during tumor formation. ROS‐sensitive TRPA1 ion channels are overexpressed in breast cancer cells and induce a large influx of Ca2+which upregulates the anti‐apoptotic pathway to lead breast cancer cells to produce oxidative stress defense and enhance the resistance to ROS related chemotherapy. Targeting and inhibiting the TRPA1 ion channels are critical for breaking down the oxidative stress defense system and overcoming cellular resistance. Here, near‐infrared (NIR) light‐responsive conjugated polymer nanoparticles are designed and prepared to promote apoptosis of breast cancer cells, reduce cell drug resistance and suppress tumor growth through the remote and precise regulation of TRPA1 ion channels. Upon 808 nm laser irradiation, the nanoparticles block the formation of Ca2+/CaM complex and regulate the content of MCL‐1 protein. Especially, the nanoparticles overcome drug resistance of cancer cells, therefore accelerating apoptosis of cancer cells and suppressing tumor growth in mice. Compared with carboplatin, the volume of tumor induced by NPs‐H decreases by 54.1%. This work provides a strategy to disrupt the oxidative stress defense system and downregulate the antiapoptotic signaling pathway in cancer cells.
Multiferroic‐Enabled Magnetic‐Excitons in 2D Quantum‐Entangled Van der Waals Antiferromagnet NiI2
Authors: Son Suhan , Lee Youjin , Kim Jae Ha , Kim Beom Hyun , Kim Chaebin , Na Woongki , Ju Hwiin , Park Sudong , Nag Abhishek , Zhou Ke‐Jin , Son Young‐Woo , Kim Hyeongdo , Noh Woo‐Suk , Park Jae‐Hoon , Lee Jong Seok , Cheong Hyeonsik , Kim Jae Hoon , Park Je‐Geun 
Published: December 2021

AbstractMatter–light interaction is at the center of diverse research fields from quantum optics to condensed matter physics, opening new fields like laser physics. A magnetic exciton is one such rare example found in magnetic insulators. However, it is relatively rare to observe that external variables control matter‐light interaction. Here, it is reported that the broken inversion symmetry of multiferroicity can act as an external knob enabling magnetic excitons in the van der Waals antiferromagnet NiI2. It is further discovered that this magnetic exciton arises from a transition between Zhang–Rice‐triplet and Zhang–Rice‐singlet fundamentally quantum‐entangled states. This quantum entanglement produces an ultrasharp optical exciton peak at 1.384 eV with a 5 meV linewidth. The work demonstrates that NiI2 is 2D magnetically ordered with an intrinsically quantum‐entangled ground state.
Severity of early diagnosed organ/space surgical site infection in elective gastrointestinal and hepatopancreatobiliary surgery
Authors: Okui Jun , Obara Hideaki , Shimane Gaku , Sato Yasunori , Kawakubo Hirofumi , Kitago Minoru , Okabayashi Koji , Kitagawa Yuko 
Published: December 2021

AbstractBackgroundOrgan/space surgical site infection (SSI) is a significant clinical problem. The postdiagnosis course of organ/space SSIs and the impact of its early diagnosis on clinical outcomes are yet to be clarified. Thus, we aimed to investigate the association between the timing of diagnosis and the clinical outcome of organ/space SSI.MethodsThis retrospective, single‐center cohort study evaluated patients who underwent elective gastrointestinal or hepatopancreatobiliary surgery between 2016 and 2020. Clinical outcomes were compared between the early group (ie, SSI diagnosed until postoperative day [POD] 4) and normal‐late group (ie, SSI diagnosed after POD 5). The primary outcome was the final C‐reactive protein (CRP) level within 14 d after organ/space SSI diagnosis.ResultsIn total, 110 patients were evaluated. The median time of diagnosis was 7 d postoperatively (interquartile range, 5–9 d postoperatively). Compared with the normal‐late group, the early group included a higher proportion of patients with Clavien–Dindo grade ≥IIIb (8/21 vs 11/89, P = .01), higher final CRP value within 14 d after SSI diagnosis (mean, 4.49 mg/dL vs 2.27 mg/dL, P = .01), longer postoperative length of hospitalization (median, 45.0 d vs 33.0 d; P = .028), and worse 1‐y overall survival rate (74.8% vs 89.3%, P = .08).ConclusionEarly diagnosed organ/space SSI are originally severe and may therefore be detected earlier. Importantly, early diagnosed organ/space SSI is likely to be severe and refractory.
Inorganic Chiral Hybrid Nanostructures for Tailored Chiroptics and Chirality‐Dependent Photocatalysis
Authors: Tan Lili , Yu Shang‐Jie , Jin Yiran , Li Jiaming , Wang Peng‐peng 
Published: December 2021

AbstractInorganic chiral hybrid nanostructures that embed chirality within distinct material compositions can create novel chiral properties and functionalities absent from achiral nanostructures; however, they remain largely unexplored. We report, for the first time, a class of chiral plasmonic metal‐semiconductor core‐shell nanostructures that employ structurally chiral nanoparticles as chirality inducing templates to grow functional shell materials, which allowed us to independently control material parameters such as core geometry and shell thickness, as well as handedness of the system. We experimentally and theoretically achieved enhanced and tunable chiroptical activity of the heterostructures as a result of the core‐shell strong coupling effect. As a proof‐of‐concept demonstration, we demonstrate that the chiral hybrid nanostructures can drive chirality‐dependent photocatalytic hydrogen generation under circularly polarized light. This study enables rational design and functionalization of chiral hybrid nanomaterials towards enhanced chiral light–matter interactions and chiral device applications.