bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sports nutrition supplements and adverse events – a meta-epidemiological study of case reports specifically addressing causality assessment
Authors: Zeijlon Rickard , Hantelius Victor , Wallerstedt Susanna M. , Holmqvist Lina 
Published: October 2021

AbstractPurposeThis meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs), specifically addressing the issue of causality assessments.MethodsThrough a systematic literature search we identified all published case reports of AEs associated with sports nutrition supplements between 1 January 2008 and 1 March 2019. Data regarding AEs, suspected supplements, relevant causality assessment factors and the reporting of clinical reasoning and/or systematic causality assessment methods were extracted.ResultsIn all, 72 publications were included, reporting 134 supplements and 37 different AEs in 97 patients (85% males; median age: 30 years [range: 14–60]). Information regarding previous health and regular prescription drugs was not presented in 30% (29/97) and 46% (45/97) of cases, respectively. In 23% (22/97) of the cases, no alternative cause was mentioned. Clinical reasoning was identified in 63% (61/97), and in 13% (8/61) of these, a systematic causality assessment method was applied. In cases with clinical reasoning, a theoretic rationale (92% vs 78%, P = 0.05), a description of previous cases (90% vs 72%, P = 0.021) and body fluid analysis (18% vs 3%, P = 0.027) were reported to a greater extent. Among cases with clinical reasoning, the application of a systematic causality assessment method captured additional important aspects: use of medication (100% vs 55%, P = 0.015), alcohol use (88% vs 43%, P = 0.020) and illicit drug use (88% vs 40%, P = 0.011).ConclusionsIn published case reports where sports nutrition supplements were suspected to have caused AEs, essential factors for causality assessment were left out in a non-negligible proportion. Clinical reasoning was identified in most cases whereas a systematic causality assessment method was applied in a minority. Factors of importance for causality assessment were reported to a greater extent in cases including clinical reasoning, and the application of a systematic causality assessment method captured additional aspects of importance.
Dual energy CT arthrography in shoulder instability: successful iodine removal with virtual non-contrast images and accurate 3D reformats of the glenoid for assessment of bone loss
Authors: Stern Christoph , Marcon Magda , Bouaicha Samy , Wieser Karl , Rosskopf Andrea B. , Sutter Reto 
Published: October 2021

Abstract

Objective
To evaluate the image quality of dual energy CT (DECT) of the shoulder after arthrography and of virtual non-contrast (VNC) 3D reformats of the glenoid and to compare glenoid measurements on VNC 3D reformats and on 2D CTs.

Materials and methods
DECT arthrography (80 kV/140 kV) was performed in 42 shoulders of 41 patients with instability using diluted iodinated contrast media (80 mg/ml). VNC images and VNC 3D reformats of the glenoid were calculated using image postprocessing. Dose parameters, CT values of intraarticular iodine and muscle, image contrast (iodine/muscle), and image quality (5-point scale: 1 = worst, 5 = best) were evaluated. Two independent readers assessed glenoid morphology and performed glenoid measurements on 2D and 3D images.

Results
Calculation of VNC images and VNC 3D reformats was successful in 42/42 shoulders (100%). The effective dose was mean 1.95 mSv (± 0.9 mSv). CT values of iodine and muscle were mean 1014.6 HU (± 235.8 HU) and 64.5 HU(± 8.6 HU), respectively, and image contrast was mean 950.2 HU (± 235.5 HU). Quality of cross-sectional images, VNC images, and VNC 3D reformats was rated good (median 4 (4–5), 4 (3–4), 4 (3–5), respectively). Detection of an osseous defect was equal on 2D and 3D images (13/42, P > 0.99) with no difference for measurement of the glenoid diameter with mean 28.3 mm (± 2.8 mm) vs. 28.4 mm (± 2.9 mm) (P = 0.5), width of the glenoid defect with 3.2 mm (± 2.1 mm) vs. 3.1 mm (± 2.3 mm) (P = 0.84), surface area with 638.5 mm2 (± 127 mm2) vs. 640.8 mm2 (± 129.5 mm2) (P = 0.47), and surface area of the defect with 46.6 mm2 (± 44.3 mm2) vs. 47.2 mm2 (± 48.0 mm2) (P = 0.73), respectively.

Conclusion
DECT shoulder arthrography is feasible and allows successful iodine removal with generation of VNC images and accurate VNC 3D reformats of the glenoid for assessment of bone loss.
Feasibility of intraoperative motor evoked potential monitoring during tethered cord surgery in infants younger than 12 months
Authors: Herta Johannes , Yildiz Erdem , Marhofer Daniela , Czech Thomas , Reinprecht Andrea , Rössler Karl , Novak Klaus 
Published: October 2021

Abstract
Purpose
Feasibility, reliability, and safety assessment of transcranial motor evoked potentials (MEPs) in infants less than 12 months of age.

Methods
A total of 22 patients with a mean age of 33 (range 13–49) weeks that underwent neurosurgery for tethered cord were investigated. Data from intraoperative MEPs, anesthesia protocols, and clinical records were reviewed. Anesthesia during surgery was maintained by total intravenous anesthesia (TIVA).

Results
MEPs were present in all patients for the upper extremities and in 21 out of 22 infants for the lower extremities. Mean baseline stimulation intensity was 101 ± 20 mA. If MEPs were present at the end of surgery, no new motor deficit occurred. In the only case of MEP loss, preoperative paresis was present, and high baseline intensity thresholds were needed. MEP monitoring did not lead to any complications. TIVA was maintained with an average propofol infusion rate of 123.5 ± 38.2 µg/kg/min and 0.46 ± 0.17 µg/kg/min for remifentanil.

Conclusion
In spinal cord release surgery, the use of intraoperative MEP monitoring is indicated regardless of the patient’s age. We could demonstrate the feasibility and safety of MEP monitoring in infants if an adequate anesthetic regimen is applied. More data is needed to verify whether an irreversible loss of robust MEPs leads to motor deficits in this young age group.
Quantifying the rarity of extreme multi-decadal trends: how unusual was the late twentieth century trend in the North Atlantic Oscillation?
Authors: Eade R. , Stephenson D. B. , Scaife A. A. , Smith D. M. 
Published: October 2021

AbstractClimate trends over multiple decades are important drivers of regional climate change that need to be considered for climate resilience. Of particular importance are extreme trends that society may not be expecting and is not well adapted to. This study investigates approaches to assess the likelihood of maximum moving window trends in historical records of climate indices by making use of simulations from climate models and stochastic time series models with short- and long-range dependence. These approaches are applied to assess the unusualness of the large positive trend that occurred in the North Atlantic Oscillation (NAO) index between the 1960s to 1990s. By considering stochastic models, we show that the chance of extreme trends is determined by the variance of the trend process, which generally increases when there is more serial correlation in the index series. We find that the Coupled Model Intercomparison Project (CMIP5 + 6) historical simulations have very rarely (around 1 in 200 chance) simulated maximum trends greater than the observed maximum. Consistent with this, the NAO indices simulated by CMIP models were found to resemble white noise, with almost no serial correlation, in contrast to the observed NAO which exhibits year-to-year correlation. Stochastic model best fits to the observed NAO suggest an unlikely chance (around 1 in 20) for there to be maximum 31-year NAO trends as large as the maximum observed since 1860. This suggests that current climate models do not fully represent important aspects of the mechanism for low frequency variability of the NAO.
Influenza and RSV incidence during COVID-19 pandemic—an observational study from in-hospital point-of-care testing
Authors: Stamm Paul , Sagoschen Ingo , Weise Kerstin , Plachter Bodo , Münzel Thomas , Gori Tommaso , Vosseler Markus 
Published: October 2021

AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has forced the implementation of unprecedented public health measures strategies which might also have a significant impact on the spreading of other viral pathogens such as influenza and Respiratory Syncytial Virus (RSV) . The present study compares the incidences of the most relevant respiratory viruses before and during the SARS-CoV-2 pandemic in emergency room patients. We analyzed the results of in total 14,946 polymerase chain reaction point-of-care tests (POCT-PCR) for Influenza A, Influenza B, RSV and SARS-CoV-2 in an adult and a pediatric emergency room between December 1, 2018 and March 31, 2021. Despite a fivefold increase in the number of tests performed, the positivity rate for Influenza A dropped from 19.32% (165 positives of 854 tests in 2018/19), 14.57% (149 positives of 1023 in 2019–20) to 0% (0 positives of 4915 tests) in 2020/21. In analogy, the positivity rate for Influenza B and RSV dropped from 0.35 to 1.47%, respectively, 10.65–21.08% to 0% for both in 2020/21. The positivity rate for SARS-CoV2 reached 9.74% (110 of 1129 tests performed) during the so-called second wave in December 2020. Compared to the two previous years, seasonal influenza and RSV incidence was eliminated during the COVID-19 pandemic. Corona-related measures and human behavior patterns could lead to a significant decline or even complete suppression of other respiratory viruses such as influenza and RSV.
A frameshift insertion in FA2H causes a recessively inherited form of ichthyosis congenita in Chianina cattle
Authors: Jacinto Joana G. P. , Häfliger Irene M. , Veiga Inês M. B. , Letko Anna , Gentile Arcangelo , Drögemüller Cord 
Published: October 2021

AbstractThe aim of this study was to characterize the phenotype and to identify the genetic etiology of a syndromic form of ichthyosis congenita (IC) observed in Italian Chianina cattle and to estimate the prevalence of the deleterious allele in the population. Sporadic occurrence of different forms of ichthyosis including IC have been previously reported in cattle. However, so far, no causative genetic variant has been found for bovine IC. Nine affected cattle presenting congenital xerosis, hyperkeratosis and scaling of the skin as well as urolithiasis and cystitis associated with retarded growth were examined. Skin histopathology revealed a severe, diffuse orthokeratotic hyperkeratosis with mild to moderate epidermal hyperplasia. The pedigree records indicated a monogenic recessive trait. Homozygosity mapping and whole-genome sequencing allowed the identification of a homozygous frameshift 1 bp insertion in the FA2H gene (c.9dupC; p.Ala4ArgfsTer142) located in a 1.92 Mb shared identical-by-descent region on chromosome 18 present in all cases, while the parents were heterozygous as expected for obligate carriers. These findings enable the selection against this sub-lethal allele showing an estimated frequency of ~ 7.5% in Chianina top sires. A sporadic incidence of mild clinical signs in the skin of heterozygous carriers was observed. So far, pathogenic variants affecting the encoded fatty acid 2-hydroxylase catalyzing the synthesis of 2-hydroxysphingolipids have been associated with myelin disorders. In conclusion, this study represents the first report of an FA2H-related autosomal recessive inherited skin disorder in a mammalian species and adds FA2H to the list of candidate genes for ichthyosis in humans and animals. Furthermore, this study provides a DNA-based diagnostic test that enables selection against the identified pathogenic variant in the Chianina cattle population. However, functional studies are needed to better understand the expression of FA2H in IC-affected Chianina cattle.
Virtual pruning of 3D trees as a tool for managing shading effects in agroforestry systems
Authors: Bohn Reckziegel Rafael , Sheppard Jonathan P. , Kahle Hans-Peter , Larysch Elena , Spiecker Heinrich , Seifert Thomas , Morhart Christopher 
Published: October 2021

AbstractLight is a limiting resource for crops within integrated land use systems especially those including woody perennials. The amount of available light at ground level can be modified by artificially pruning the overstory. Aiming to increase the understanding of light management strategies, we simulated the pruning of wild cherry trees and compared the shading effects of the resulting tree structures over a complete growing season, with fine spatiotemporal resolution. Original 3D-tree structures were retrieved employing terrestrial laser scanning and quantitative structure models, and subjected to two pruning treatments at low and high intensities. By using the ‘shadow model’, the analogous tree structures created diverse shaded scenarios varying in size and intensity of insolation reduction. Conventional pruning treatments reduced the crown structure to the uppermost portion of the tree bole, reducing the shading effects, and thus, shrinking the shaded area on the ground by up to 38%, together with the shading intensity. As an alternative, the selective removal of branches reduced the shading effects, while keeping a more similar spatial distribution compared to the unpruned tree. Hence, the virtual pruning of tree structures can support designing and selecting adequate tending operations for the management of light distribution in agroforestry systems. The evidence assembled in this study is highly relevant for agroecosystems and can be strategically used for maintaining, planning and designing integrated tree-crop agricultural systems.
Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway
Authors: Sánchez-Botet Abril , Quandt Eva , Masip Núria , Escribá Rubén , Novellasdemunt Laura , Gasa Laura , Li Vivian S. W. , Raya Ángel , Clotet Josep , Ribeiro Mariana P. C. 
Published: October 2021

Abstract
Purpose
Cancer stem cells represent a cancer cell subpopulation that has been found to be associated with metastasis and chemoresistance. Therefore, it is vital to identify mechanisms regulating cancer stemness. Previously, we have shown that the atypical cyclin P (CCNP), also known as CNTD2, is upregulated in lung and colorectal cancers and is associated with a worse clinical prognosis. Given that other cyclins have been implicated in pluripotency regulation, we hypothesized that CCNP may also play a role in cancer stemness.

Methods
Cell line-derived spheroids, ex vivo intestinal organoid cultures and induced-pluripotent stem cells (iPSCs) were used to investigate the role of CCNP in stemness. The effects of CCNP on cancer cell stemness and the expression of pluripotency markers and ATP-binding cassette (ABC) transporters were evaluated using Western blotting and RT-qPCR assays. Cell viability was assessed using a MTT assay. The effects of CCNP on WNT targets were monitored by RNA-seq analysis. Data from publicly available web-based resources were also analyzed.

Results
We found that CCNP increases spheroid formation in breast, lung and colorectal cancers, and upregulates the expression of stemness (CD44, CD133) and pluripotency (SOX2, OCT4, NANOG) markers. In addition, we found that CCNP promotes resistance to anticancer drugs and induces the expression of multidrug resistance ABC transporters. Our RNA-seq data indicate that CCNP activates the WNT pathway, and that inhibition of this pathway abrogates the increase in spheroid formation promoted by CCNP. Finally, we found that CCNP knockout decreases OCT4 expression in iPSCs, further supporting the notion that CCNP is involved in stemness regulation.

Conclusion
Our results reveal CCNP as a novel player in stemness and as a potential therapeutic target in cancer.
The utility of PET imaging in the diagnosis and management of psychosis: a brief review
Authors: Rigney Grant , Ayubcha Cyrus , Werner Thomas J. , Alavi Abass , Revheim Mona-Elisabeth 
Published: October 2021

Abstract
Purpose
Advances in the pathophysiological characterization of psychosis has led to a newfound role of biomarkers in diagnostic and prognostic contexts. Further, advances in the accuracy and sensitivity of nuclear medicine imaging techniques, and specifically positron emission tomography (PET), have improved the ability to diagnose and manage individuals experiencing first-episode psychosis or those at greater risk for developing psychosis.

Methods
Literature searches were performed in PubMed, Google Scholar, and Web of Science to identify papers related to the use of PET imaging in the diagnosis or management of psychosis. Search terms used included “positron emission tomography”, “PET imaging”, “psychosis”, “disorders of psychosis”, “schizophrenia”, “biomarkers”, “diagnostic biomarkers”, “prognostic biomarker”, “monitoring biomarker”, “outcome biomarker”, and “predictive biomarker.”

Results
Studies included fell into three categories: those examining microglia, those studying dopamine synthesis capacity, and those examining acetylcholine receptor activity. Microglial imaging has been shown to be ineffective in all patients with psychosis, but some believe it shows promise in a subset of patients with psychosis, although no defining characteristics of said subset have been postulated. Studies of dopamine synthesis capacity suggest that presynaptic dopamine is reliably elevated in patients with psychosis, but levels of dopamine active transporter are not. Further, positron emission tomography (PET) with [18F]fluoro-l-dihydroxyphenylalanine ([18F]FDOPA)-PET has been recently used successfully as a predictive biomarker of dopaminergic treatment response, although more work is needed to validate such findings. Finally, existing studies have also documented lower levels of binding to the α7 nicotinic cholinergic receptor (α7-nAChR) via [18F]-ASEM PET in patients with psychosis, however there is a dearth of prospective, randomized studies evaluating the efficacy of [18F]-ASEM as a diagnostic or monitoring biomarker of any kind.

Conclusion
Molecular imaging has become a useful tool in the diagnosis and management of psychosis. Further work must be done to improve the comparative prognostic value and diagnostic accuracy of different radiotracers.
A confirmatory composite analysis for the Italian validation of the interactions anxiousness scale: a higher-order version
Authors: Ciavolino Enrico , Ferrante Lucrezia , Sternativo Giovanna Alessia , Cheah Jun-Hwa , Rollo Simone , Marinaci Tiziana , Venuleo Claudia 
Published: October 2021

AbstractThis study examined the factor structure and model specifications of the Interaction Anxiousness Scale (IAS) with confirmatory composite analysis (CCA) using partial least squares-structural equation modeling (PLS-SEM) with a sample of Italian adolescents ($$n = 764$$

n
=
764

). The CCA and PLS-SEM results identified the reflective nature of the IAS sub-scale scores, supporting an alternative measurement model of the IAS scores as a second-order reflective–reflective model.
Artificial Neural Networks on FPGAs for Real-Time Energy Reconstruction of the ATLAS LAr Calorimeters
Authors: Aad Georges , Berthold Anne-Sophie , Calvet Thomas , Chiedde Nemer , Fortin Etienne Marie , Fritzsche Nick , Hentges Rainer , Laatu Lauri Antti Olavi , Monnier Emmanuel , Straessner Arno , Voigt Johann Christoph 
Published: October 2021

AbstractThe ATLAS experiment at the Large Hadron Collider (LHC) is operated at CERN and measures proton–proton collisions at multi-TeV energies with a repetition frequency of 40 MHz. Within the phase-II upgrade of the LHC, the readout electronics of the liquid-argon (LAr) calorimeters of ATLAS are being prepared for high luminosity operation expecting a pileup of up to 200 simultaneous proton–proton interactions. Moreover, the calorimeter signals of up to 25 subsequent collisions are overlapping, which increases the difficulty of energy reconstruction by the calorimeter detector. Real-time processing of digitized pulses sampled at 40 MHz is performed using field-programmable gate arrays (FPGAs). To cope with the signal pileup, new machine learning approaches are explored: convolutional and recurrent neural networks outperform the optimal signal filter currently used, both in assignment of the reconstructed energy to the correct proton bunch crossing and in energy resolution. The improvements concern in particular energies derived from overlapping pulses. Since the implementation of the neural networks targets an FPGA, the number of parameters and the mathematical operations need to be well controlled. The trained neural network structures are converted into FPGA firmware using automated implementations in hardware description language and high-level synthesis tools. Very good agreement between neural network implementations in FPGA and software based calculations is observed. The prototype implementations on an Intel Stratix-10 FPGA reach maximum operation frequencies of 344–640 MHz. Applying time-division multiplexing allows the processing of 390–576 calorimeter channels by one FPGA for the most resource-efficient networks. Moreover, the latency achieved is about 200 ns. These performance parameters show that a neural-network based energy reconstruction can be considered for the processing of the ATLAS LAr calorimeter signals during the high-luminosity phase of the LHC.
Moving beyond (id)entities, toward emergent becomingsofthe world and its mattering
Authors: Davies Bronwyn 
Published: October 2021

AbstractIn the last 30 years we have increasingly, as humans, been individualised and set in competition with each other in the quest for ever increasing productivity. Neoliberalism has exacerbated those very liberal humanist features that feminist poststructuralist theory set out to dismantle with its critique of binary thought and the ascendance of white, male, elite, western consciousness. While transferring the responsibility for individual survival to the individual, away from the social, it weakened our responsibility, our response-ability, to each other and to the earth and our earth others. In this paper I tease my way, through stories, and through new materialist concepts, to a sense of self as emergent, as process rather than (id)entity, as response-able and responsible in the mattering of the world.
Transformative Choices and the Specter of Regret
Authors: HOWARD DANA 
Published: October 2021

AbstractWhen people are making certain medical decisions—especially potentially transformative ones—the specter of regret may color their choices. In this essay, I ask whether predicting that we will regret a decision in the future serve any justificatory role in our present decision making. And if so, what role? While there are many pitfalls to such reasoning, I ultimately conclude that considering future retrospective emotions like regret in our decision making can be both rational and authentic. Rather than indicating that one is about to make a mistake or that there is some underlying value that one already cares about but is overlooking, the prediction that one will regret a decision in the future makes one confront how her present values and priorities may change as a result of her choice in ways she cannot at present anticipate.
Corporate Repertoires of Control and Performances of Power in a Contested Land Deal in Senegal
Authors: Gagné Marie 
Published: October 2021

AbstractFarmland investments have attracted numerous entrepreneurs and companies to Africa in the past two decades. However, acquiring, retaining, and exploiting large-scale landholdings is more complicated than it seems. Investors need to persuade governments and populations of their anticipated benefits and limit dissenting voices when they emerge. Focusing on a contested land project in Senegal, Gagné develops the concept of “repertoires of control” to analyze the different performances of power that companies deploy to assert and legitimize their land claims. She argues that to survive, companies must continually adapt these performances to changes in the political environment of their host countries.