bluuebunny/crossref_metadata_2025_split huggingface dataset:
Callispheres® Drug-Eluting Beads Transarterial Chemoembolization Might be an Efficient and Safety Down-Staging Therapy in Unresectable Liver Cancer Patients
Authors: Peng Ning , Mao Linfeng , Tao Yiwen , Xiao Kaiyin , Yuan Guandou , He Songqing 
Published: November 2021

Abstract
Purpose: The purpose was to explore the effect of drug-eluting beads transarterial chemoembolization (DEB-TACE) on down-staging in unresectable liver cancer patients.Methods: 15 unresectable liver cancer patients received DEB-TACE as a down-staging treatment before hepatectomy were enrolled. Data (including demographics, histories, clinical features at diagnosis and cycles of DEB-TACE before hepatectomy) were collected. Treatment response was evaluated at one month after DEB-TACE. Tumor diameter was evaluated by abdominal computed tomography scan. The residual liver volume was evaluated by IQQA liver system, Relapse-free survival (RFS) and overall survival (OS) were calculated by Kaplan-Meier curves.Results: After DEB-TACE, 3 (20.0%) patients achieved complete response (CR) and 10 (66.7%) patients achieved objective response rate (ORR), meanwhile, 5 (27.8%) tumors achieved CR and 12 (66.7%) tumors achieved ORR. Tumor diameter was decreased after DEB-TACE compared to before DEB-TACE (9.4±3.3 vs. 5.4±3.5 cm) (P<0.01). As to residual liver volume, it was increased after DEB-TACE compared to before DEB-TACE (1066.2 cm3 vs. 1172.5 cm3) (P=0.007). More importantly, 15 (100%) patients could receive resection after DEB-TACE, (including 14 (93.3%) patients with curative resection and 1 (6.7%) patient with palliative resection). For survival, the median RFS was 26.0 months, and the percentage of 5-year accumulating RFS was 20%. As to OS, the median OS was 54.5 months, and the percentage of 5-year accumulating OS was 40%. For safety profiles, 5 patients had postoperative pain, 7 patients had fever, and 1 had nausea and vomiting.Conclusion: DEB-TACE might be an efficient and safety down-staging treatment in unresectable liver cancer patients.
Building evidence into youth health policy: a case study of the access 3 knowledge translation forum
Authors: Waller Daniel , Robards Fiona , Schneider Carmen Huckel , Sanci Lena , Steinbeck Katharine , Gibson Sally , Usherwood Tim , Hawke Catherine , Jan Stephen , Kong Marlene , Kang Melissa 
Published: November 2021

Abstract
Background

Effective integration of research evidence and youth perspectives into policy is crucial for supporting the future health and wellbeing of young people. The aim of this project was to translate findings from the Access 3 research studies to support development of a new state policy on youth health and wellbeing within New South Wales, Australia. Ensuring the active contribution of young people within policy development was a key objective of the knowledge translation process.
Methods

The knowledge translation activity consisted of a one-day facilitated workshop with 64 purposively sampled stakeholders. Participants included eight young people, fourteen policymakers, fifteen academics, twenty-two clinicians or managers from New South Wales (NSW) health services, four general practitioners and one mental health service worker. The design of the workshop was guided by the knowledge translation frameworks of Lavis et al [1] and Grimshaw et al [2]. Research findings to be translated came from the NSW Access 3 studies. Participant satisfaction with the workshop was evaluated using a brief self-report survey. Policy uptake was examined through exploratory document analysis of the subsequent NSW Youth Health Framework 2017-2024.
Results

A total of twenty-five policy recommendations were established through the workshop and these were grouped into six themes. The six policy themes were: 1) Technology solutions, 2) Integrated care and investment to build capacity, 3) Adolescent health checks, 4) Workforce, 5) Youth participation, and 6) Youth health indicators. Forum members were asked to vote on the importance of individual recommendations. These policy recommendations were subsequently presented to the NSW Ministry of Health with some evidence of policy uptake identified. The majority of participants rated the forum positively.
Conclusions

The utilisation of knowledge translation theories and active youth engagement led to the successful transfer of research evidence and youth perspectives into NSW youth health policy. Future research should examine the implementation of policy arising from these knowledge translation efforts.
Mechanical Properties And Joining Mechanism of Magnetic Pulse Welded Aluminum To Titanium
Authors: Chen Shujun , Han Yang , Gong Wentao , Yuan Tao , Jiang Xiaoqing 
Published: November 2021

Abstract
Magnetic pulse welding of dissimilar aluminum and titanium was investigated to optimize process parameters in terms of discharge voltage, radial gap and overlapping length. Moreover, impacting modes at different overlapping lengths were discussed. The joining mechanism was analyzed from aspects of microstructure, composition and hardness distribution. The shear strength increased with increasing discharge voltages, whereas shear strength decreased at first and then increased with the increasing radial gap, which has a more significant influence on shear strength than discharge voltage. Three impacting modes were proposed as bidirectional impacting, overall impacting and single-orientation impacting. However, the single-orientation impacting mode has the highest effective joining ratio. The welded joints were divided into four transition layer interfaces: continuous transition zone, transition zone with cracks, intermittent transition zone, and non-transition zone. Waves and intermetallic compounds are the two characteristics of the Al-Ti joint welded by magnetic pulse welding. The metal's hardness near the joint surface is higher than that of the base metal. In addition, Al3Ti and aluminum base metal were found in the transition layer of the joint.
Novel and Real-Time GPU Accelerated Speed Violation Detection and License Plate Identification System
Authors: Dampage Udaya , Hasantha KKN , Gimhana HADS , Bandara HMTYN , Maddumage SV 
Published: November 2021

Abstract
Commuters lose a lot of time and effort due to the inefficiency of traffic management. Although nowadays most of the processes are automated, it seems a speed violation detection is the least focused area apart from using speed guns which the RADAR may make mistakes and yet, doing such will benefit people by saving their time and let them escape from the troublesome situations. To address this issue, a real-time solution by fully automating the process of detecting the speed violation and the license plates of the offenders is proposed in this paper. A vehicle approaching a specific area will be automatically identified and tracked from a reference starting point. Within the covered range of the camera according to the traffic density present at that instance, the maximum speed for a vehicle is estimated and the vehicles that exceed the stipulated limit are identified as a violation. The core part of the proposed system is license plate recognition. To properly extract the license plate with the best view to proceed with the identification process is another problem that needs to be focused on. We utilized deep neural networks in a novel way for the aforesaid purpose. As these neural networks consist of numerous parameters, we utilized GPU for processing to gain smoothness in real-time. Using our novel segmentation free license plate identification method which utilizes object detection principle to fully capture the speed violation along with its offender. Numerous field trials proved that the proposed methodology provides far superior performance levels compared to the conventional systems and the other existing methodologies, which will certainly cater to the demanding requirements of Transportation 4.0.
Scaling-up filariasis lymphoedema management into the Primary Health Care System in Kerala State, Southern India - an example of equity in healthcare.
Authors: Krishnasastry Suma , Mackenzie Charles D. , Sadanandan Rajeev 
Published: November 2021

Abstract
Background: Lymphatic filariasis remains one the world’s most debilitating parasitic infections and is a major contributor to poor health in many endemic countries. The provision of continuing care for all those affected by this infection and its consequences is an important component of the United Nations’ Sustainable Development Goals. The World Health Organization’s recommendation for achieving this goal is for countries to integration their lymphedema care into the primary health care system. Methods:To fulfil the WHO recommendation for providing care for all those affected with lymphoedema caused by lymphatic filariasis, selected health care providers from each of the endemic districts in Kerala participated in intensive training sessions endorsed by the State’s medical administration. The six training sessions included appropriate self-care information and the development of individual plans for each participating institution to provide instruction and care for their lymphoedema patients. The learning achieved by attendees was assessed during the training sessions by pre- and post-training testing. The number of lymphoedema patients receiving care and instruction from the post-training activities of each participating institution was assessed from local records, six months after the conclusion of the training sessions.Results:One hundred and eighty-four medical personnel (91 doctors and 93 staff nurses) from 82 medical institutions were trained which quickly led to the establishment of active lymphoedema clinics providing the essential package of care (EPC) for lymphoedema patients at all the participating institutions. Six months after the training sessions the number of previously unidentified lymphoedema patients registered and receiving care at these clinics ranged from 296 to almost 400 per clinic, with a total of 3477 new patients receiving training in the EPC during this period.Conclusions:Generalist health personnel, when appropriately trained, can provide quality lymphoedema care in public health settings, and that patients, when provided services close to their home, are willing to access these services. This approach is a feasible strategy for integrating long term care for LF patients into a national health system, and is a clear example of moving towards equity in health care for the medically underserved, and thus successfully addresses a major goal of the global program to eliminate lymphatic filariasis (GPELF).
In-vitro seed germination Trial for the population Terminalia ivorensis Collected from Benchi-Maji zone, south western Ethiopia
Authors: Adefa Mohammed , Mengesha Yigardu , Ayalew Semaigzer , Nigatu Marshet , Kebede Wondu 
Published: November 2021

Abstract
Tree seeds exhibit some degree of dormancy. Similarly, the seeds of Terminalia ivorensis germinate with great difficulties. To break the dormancy and improve the germination capability of seeds, different types of mechanical and physiological approaches can be followed. Accordingly, the seeds of T. ivorensis were subjected to two pre-sowing treatments (one is with seeds soaked in water for 24 hours and the other is with seeds soaked for 10 minutes in 80% concentrated H2SO4 then abundantly rinsed in running water for 20 minutes) in addition to the control one. So, a total of 100 seeds divided into 4 replications (25 seeds per tray) were tested for each treatment. Then, treated seeds were sown in sand tray to seed the germination characteristic of the different treatments. The sown seeds were followed up for 5 months with proper watering, and the germination record was taken accordingly. Analysis of the germination of the different treatments shows that seeds that were not treated exhibits better mean germination percentages (62%) followed by the one with seeds soaked for 24 hours (47%). However, seeds treated with 80% [H2SO4] for 10 minutes then abundantly rinsed in running water for 20 minutes showed no germination. So, both the 62% and 47% germination recorded are fairly accepted results considering the low germination capacity of T. ivorensis in laboratory and natural conditions. However, other possible pre-sowing treatment techniques can be studied and incorporated for increasing the seed germination of T. ivorensis in-vitro in addition to the records obtained in this trial.
Acidic Skin Care Promotes Cutaneous Microbiome Recovery And Skin Physiology in An Acute Stratum Corneum Stress Model
Authors: Fluhr Joachim W. , Menzel Peter , Schwarzer Rolf , Kaestle Benjamin , Arens-Corell Michaela , Praefke Lina , Tsankov Nikolai , Nikolaeva Dessislava G. , Miséry Laurent , Darlenski Razvigor 
Published: November 2021

Abstract
Background: The skin microbiome and skin physiology are important indicators of the epidermal homeostasis status. Stress models are used to reveal pathological conditions and modulating effects. The recovery phase served to investigate the cutaneous microbiome in relation to skin physiology after mild tape stripping without treatment compared to two cosmetic leave-on lotions (pH 5.5 vs. pH 9.3). Material and MethodsThe prospective, randomized, controlled study was performed in 25 healthy volunteers: The microbiome was assessed via swabs and subsequent 16S-rRNA-gene amplicon sequencing. Skin physiology was analyzed in terms of barrier function, stratum corneum hydration, surface-pH, skin color non-invasively. All parameters were assessed before and immediately after 2hrs., 2 days and 7 days after tape stripping. Lotion A (pH 5.5) and the identical lotion B (pH 9.3) were applied 2-times per day for 7 days on the volar forearm.ResultsTape stripping reduced the alpha diversity with a recovery over 7 days without treatment. Both lotions significantly accelerated the recovery of the alphadiversity already after 2 days with a slightly higher rate for lotion A (pH 5.5). After tape stripping, the relative abundance of Proteobacteria was increased, whereas Actinobacteria were reduced. Further, mean relative abundances of typical skin-associated genera were reduced after tape stripping. Taxa compositions returned to normal levels after 7 days in all treatment groups, and an accelerated normalization could be observerd with treatment by both lotions already after tow days. A significant difference in skin-pH was observed at day2 and day7 with an increased pH in lotion B treatment. Both lotions induced an increase in stratum corneum hydration. Barrier function was only changed by tape stripping. DiscussionThe study proved the suitability of an experimental stress model in the assessment of skin surface microbiome in relation to skin physiology. Stratum corneum hydration increased significantly with both lotions already at day 2. Microbiome parameters (alpha-diversity, mean relative taxa, abundance of selected genera) normalized over 2-7 days. Three potential mechanisms could be responsible for the accelerated normalization: a) optimized hydration during the recovery phase b) the composition of the lotion, c) acidic pH of the lotion.
TNF-α activates WNT5A, which recruits osteoclast precursors by MCP-1 production, but not directly activates osteoclastogenesis, in psoriatic arthritis
Authors: Lin Shang-Hung , Ho Ji-Chen , Hsu Chung-Yuan , Li Sung-Chou , Chou Wen-Yi , Hsiao Chang Chun , Lee Chih-Hung 
Published: November 2021

Abstract
Background:

Psoriatic arthritis (PsA) results from joint destruction by osteoclasts. Promising efficacy of TNF-α blockage indicates its important role in osteoclastogenesis of PsA. WNT ligands actively regulate osteoclastogenesis. We investigated how WNT ligands activate osteoclasts amid the TNF-α milieu in PsA.
Methods:

We first profiled the expression of WNT ligands in CD14+ monocyte-derived osteoclasts (MDOC) from 3 PsA patients and 3 healthy controls (HC) and then validated the candidate WNT ligands in 32 PsA patients and 16 HC. Through RNA interference against WNT ligands in MDOC, we determined the mechanisms by which TNF-α exerts its effects on osteclastogenesis or chemotaxis.
Results:

The results showed numbers of CD68+WNT5A+ osteoclasts are increased in PsA joints. WNT5A was selectively upregulated by TNF-α in MDOC from PsA patients. However, direct osteoclastogenesis effect (RANK expression) by TNF-αwas not inhibited by WNT5A siRNA. Instead, CXCL1, CXCL16, and MCP-1 was selectively increased in supernatants of MDOC from PsA patients. RNA interference against WNT5A abolished the increased MCP-1 from MDOC and THP-1-cell-derived osteoclasts. The increased migration of osteoclast precursors (OCP) induced by supernatant from PsA MDOC was abolished by MCP-1 neutralizing antibody. WNT5A and MCP-1 expressions were decreased in MDOC from PsA patients treated by biologics against TNF-a but not IL-17.
Conclusion:

We conclude TNF-α recruits OCP by WNT5A-mediated MCP-1 production but not directly activates osteoclastogenesis in PsA.
Feedback Control Based Active Cooling With Pre-estimated Reliability For Stabilizing The Thermal Error of a Precision Mechanical Spindle
Authors: Lei Mohan , Gao Feng , Li Yan , Xia Ping , Wang Mengchao , Yang Jun 
Published: November 2021

Abstract
Thermal error stability (STE) of the spindle determines the machining accuracy of a precision machine tool. Here we propose a thermal error feedback control based active cooling strategy for stabilizing the spindle thermal error in long-term. The strategy employs a cooling system as actuator and a thermal error regression model to output feedback. Structural temperature measurements are considerably interfered by the active cooling, so the regression models trained with experimental data might output inaccurate feedbacks in unseen work conditions. Such inaccurate feedbacks are the major cause for excessive fluctuations and failures of the thermal error control processes. Independence of the thermal data is analyzed, and a V-C (Vapnik-Chervonenkis) dimension based approach is presented to estimate the generalization error bound of the regression models. Then, the model which is most likely to give acceptable performance can be selected, the reliability of the feedbacks can be pre-estimated, and the risk of unsatisfactory control effect will be largely reduced. Experiments under different work conditions are conducted to verify the proposed strategy, the thermal error is stabilized to be within a range smaller than 1.637μm, and thermal equilibrium time is advanced by more than 78.3%.
Angiotensin-converting enzyme 2 SNPs as the common genetic loci and optimal early identification genetic markers for COVID-19
Authors: Zou Heng , Li Qiuyue , Chen Jun , Liu Songmei , Liu Shanshan , Ma Yan , He Xiaomeng , Ling Yun , Zheng Jianghua , Corpe Christopher , Lu Hongzhou , Wang Jin 
Published: November 2021

Abstract
Background

Angiotensin-converting enzyme 2 (ACE2) is implicated as a host cell receptor that causes infection in the pathogenesis of Coronavirus disease 2019 (COVID-19), and its genetic polymorphisms in the ACE2 gene may promote cardiovascular disease and systemic inflammatory injury in COVID-19. Hence, genetic background may potentially explain the broad inter-individual variation of disease susceptibility and/or severity.
Methods

The genetic susceptibility to COVID-19 by examining single-nucleotide polymorphisms (SNPs) of ACE2 was analyzed in 196 patients with COVID-19 and 210 normal controls using TaqMan genotyping assay.
Results

We demonstrated that ACE2 SNP rs4646142, rs6632677, and rs2074192 were associated with COVID-19 (all P < 0.05), and the differences of ACE2 SNPs rs4646142 and rs6632677 were correlated with COVID-19 related systemic inflammatory injury and cardiovascular risk. Specially, rs4646142 was associated with high-sensitive C-reactive protein (hs-CRP), prealbumin (PAB), apolipoprotein A (APOA), high-density lipoprotein (HDL), and acid glycoprotein (AGP). Rs6632677 was also associated with elevated CRP and haptoglobin (HPT).
Conclusions

Our results suggest that early identification of these individuals can provide a possible strategy for preventing the spread of the COVID-19, and ACE2 SNPs rs4646142 and rs6632677 may be a common genetic loci and optimal early identification genetic marker for COVID-19 with cardiovascular risks.
Quercetin inhibits the tumorigenesis of colorectal cancer cells through downregulation of hsa_circ_0006990
Authors: Chen Bin , Xiao Haijuan , Wu Linguangjin , Wang Ting , Wang Shuyun , Yu Hongjie , Wan Guangsheng , Xie Manli , He Xinhong , Xu Wen , Zhang Ruijuan , Deng Wanli 
Published: November 2021

Abstract
Background

This study was intended to investigate the function of Quercetin in chemoresistant colorectal cancer (CRC) cells. In addition, this research aimed to explore the mechanism by which Quercetin regulates the malignant behavior of CRC cells.
Methods

To induce THP-1 cells into M2 tumor-associated macrophages (M2-TAMs), THP-1 cells were stimulated by PMA and IL-4. MDC staining was used to investigate the autophagy in M2-TAMs. Meanwhile, cell proliferation was tested by colony formation assay. In addition, wound healing and transwell assay were performed to detect the cell migration and invasion, respectively. Dual luciferase assay was used to investigate the correlation between hsa_circ_0006990 and miR-132-3p/miR-532-3p. Furthermore, mRNA and protein levels were detected by RT-qPCR and western blot, respectively.
Results

Quercetin suppressed autophagy of M2-TAMs. In addition, M2-TAMs significantly inhibited the apoptosis and promoted the proliferation of CRC cells, while this phenomenon was reversed by Quercetin. Meanwhile, the expression of hsa_circ_0006990 in CRC cells was decreased by M2-TAMs, while Quercetin reversed this phenomenon. Furthermore, overexpression of hsa_circ_0006990 significantly reversed the anti-tumor effect of Quercetin on CRC.
Conclusion

Quercetin inhibited the tumorigenesis of colorectal cancer cells through downregulation of hsa_circ_0006990. Thus, our study might shed new lights on exploring the new strategies against CRC.
The Association between Season and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis
Authors: Liao Lingyun , Wei Xiaohong , Liu Min , Gao Yijie , Yin Yangxue , Zhou Rong 
Published: November 2021

Abstract
Background: There is increasing and inconsistent evidence of a relationship between hypertensive disorders of pregnancy (HDP) and season of delivery or conception.Methods: Four databases, the Cochrane Library, PubMed, EMBASE and Web of Science, were searched until September 29th, 2021. Two authors extracted data independently. A random effects model and the Mantel-Haenszel method were used to calculate pooled ORs and 95% CIs.Results: Twenty articles were included in the systematic review, and 11 articles were included in the meta-analysis. The quantitative analysis of the association between delivery season and HDP showed that the odds of HDP was higher in women who deliver in winter than in those who delivered in summer (OR=1.18, 95% CI 1.02-1.38, p < 0.001) and all other seasons (OR = 1.17, 95% CI 1.03-1.34, p <0.001). In the qualitative analysis of the association between conception season and HDP, 4 of 7 studies suggested that women who conceived in summer had a higher risk of HDP than those who conceived in other seasons.Conclusions: Based on the evidence to date, we found weakly positive relationships between HDP and summer conception and winter delivery.