bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coma morphology and dust emission pattern of comet C/2020 F3 (NEOWISE)
Authors: Manzini F , Oldani V , Ochner P , Barbotin E , Bedin L R , Behrend R , Fardelli G 
Published: June 2021

ABSTRACT
The recent close approach of comet C/2020 F3 (NEOWISE) allowed us to study the morphology of its inner coma. From the measurement of the dust ejection velocity on spiral structures expanding around the nucleus, we estimated a mean deprojected expansion velocity Vd = 1.11 ± 0.08 km s−1. Assuming that a new shell formed after every rotation of the comet, a period of 7.8 ± 0.2 h was derived. The spin axis orientation was estimated at RA 210° ± 10°, Dec. +35° ± 10°. The coma morphology appears related to two strong, diametrically opposite emissions located at mid-latitudes on the nucleus. A qualitative modelling of the coma produced consistent results with a wide range of dust sizes (0.80–800 μm), with inversely correlated densities (0.003–3.0 g cm−3). Images taken with Vj and r-Sloan filters showed a greater concentration of dust in the first two shells, and an increasing density of radicals emitting in the B and V band passes from the third shell outwards. Striae-like structures in the tail suggest that dust particles have different sizes.
RBFOX2 alters splicing outcome in distinct binding modes with multiple protein partners
Authors: Zhou Delong , Couture Sonia , Scott Michelle S , Abou Elela Sherif 
Published: June 2021

Abstract
RBFOX2 controls the splicing of a large number of transcripts implicated in cell differentiation and development. Parsing RNA-binding protein datasets, we uncover that RBFOX2 can interact with hnRNPC, hnRNPM and SRSF1 to regulate splicing of a broad range of splicing events using different sequence motifs and binding modes. Using immunoprecipitation, specific RBP knockdown, RNA-seq and splice-sensitive PCR, we show that RBFOX2 can target splice sites using three binding configurations: single, multiple or secondary modes. In the single binding mode RBFOX2 is recruited to its target splice sites through a single canonical binding motif, while in the multiple binding mode RBFOX2 binding sites include the adjacent binding of at least one other RNA binding protein partner. Finally, in the secondary binding mode RBFOX2 likely does not bind the RNA directly but is recruited to splice sites lacking its canonical binding motif through the binding of one of its protein partners. These dynamic modes bind distinct sets of transcripts at different positions and distances relative to alternative splice sites explaining the heterogeneity of RBFOX2 targets and splicing outcomes.
EANO guideline on the diagnosis and management of meningiomas
Authors: Goldbrunner Roland , Stavrinou Pantelis , Jenkinson Michael D , Sahm Felix , Mawrin Christian , Weber Damien C , Preusser Matthias , Minniti Giuseppe , Lund-Johansen Morten , Lefranc Florence , Houdart Emanuel , Sallabanda Kita , Le Rhun Emilie , Nieuwenhuizen David , Tabatabai Ghazaleh , Soffietti Riccardo , Weller Michael 
Published: June 2021

Abstract
Meningiomas are the most common intracranial tumors. Yet, only few controlled clinical trials have been conducted to guide clinical decision making, resulting in variations of management approaches across countries and centers. However, recent advances in molecular genetics and clinical trial results help to refine the diagnostic and therapeutic approach to meningioma. Accordingly, the European Association of Neuro-Oncology (EANO) updated its recommendations for the diagnosis and treatment of meningiomas. A provisional diagnosis of meningioma is typically made by neuroimaging, mostly magnetic resonance imaging. Such provisional diagnoses may be made incidentally. Accordingly, a significant proportion of meningiomas, notably in patients that are asymptomatic or elderly or both, may be managed by a watch-and-scan strategy. A surgical intervention with tissue, commonly with the goal of gross total resection, is required for the definitive diagnosis according to the WHO classification. A role for molecular profiling including gene panel sequencing and genomic methylation profiling is emerging. A gross total surgical resection including the involved dura is often curative. Inoperable or recurrent tumors requiring treatment can be treated with radiosurgery, if the size or the vicinity of critical structures allows that, or with fractionated radiotherapy (RT). Treatment concepts combining surgery and radiosurgery or fractionated RT are increasingly used, although there remain controversies regard timing, type, and dosing of the various RT approaches. Radionuclide therapy targeting somatostatin receptors is an experimental approach, as are all approaches of systemic pharmacotherapy. The best albeit modest results with pharmacotherapy have been obtained with bevacizumab or multikinase inhibitors targeting vascular endothelial growth factor receptor, but no standard of care systemic treatment has been yet defined.
‘Alms! Alms! Give us some support!’: an inquiry on the homeless
Authors: Pacaol Niñoval F 
Published: June 2021

Abstract
COVID-19 is an infectious disease caused by a new coronavirus named SARS-CoV-2. The prevalence of the virus on a global scale led to a global health crisis which prompted countries like the Philippines to address the issue through the implementation of various health-related protocols, legislative laws, and COVID-19 mass vaccination programs for the establishment of herd immunity. Such government actions are undeniably significant in resolving the booming positive cases but the subjects (or who should receive the services) are, to some extent, unclear and overlooked the situation of ‘Others’ – the homeless. The author argues that the Philippine government, other social institutions, and organizations must consider the well-being of this group as one of the hidden disadvantaged individuals amid the crisis.
Managing to climatology: Improving semi-arid agricultural risk management using crop models and a dense meteorological network
Authors: Mauget Steven A , Mitchell-McCallister Donna 
Published: June 2021

AbstractWithout reliable seasonal climate forecasts, farmers and managers in other weather-sensitive sectors might adopt practices that are optimal for recent climate conditions. To demonstrate this principle, crop simulation models driven by a dense meteorological network were used to identify climate-optimal planting dates for US Southern High Plains (SHP) unirrigated agriculture. This method converted large samples of SHP growing season weather outcomes into climate-representative cotton and sorghum yield distributions over a range of planting dates. Best planting dates were defined as those that maximized median cotton lint (April 24) and sorghum grain (July 1) yields. Those optimal yield distributions were then converted into corresponding profit distributions reflecting 2005–19 commodity prices and fixed production costs. Both crops’ profitability under variable price conditions and current SHP climate conditions were then compared based on median profit and loss probability, and through stochastic dominance analyses that assumed a slightly risk-averse producer.
Conditional Superior Predictive Ability
Authors: Li Jia , Liao Zhipeng , Quaedvlieg Rogier 
Published: June 2021

AbstractThis article proposes a test for the conditional superior predictive ability (CSPA) of a family of forecasting methods with respect to a benchmark. The test is functional in nature: under the null hypothesis, the benchmark’s conditional expected loss is no more than those of the competitors, uniformly across all conditioning states. By inverting the CSPA tests for a set of benchmarks, we obtain confidence sets for the uniformly most superior method. The econometric inference pertains to testing conditional moment inequalities for time series data with general serial dependence, and we justify its asymptotic validity using a uniform non-parametric inference method based on a new strong approximation theory for mixingales. The usefulness of the method is demonstrated in empirical applications on volatility and inflation forecasting.
Relationships between cortical, cardiac, and arousal-motor activities in the genesis of rhythmic masticatory muscle activity across sleep cycles in primary sleep bruxism children
Authors: Shiraishi Yuki , Tachibana Masaya , Shirota Ai , Mohri Ikuko , Taniike Masako , Yamashiro Takashi , Kato Takafumi 
Published: June 2021

Abstract

Study Objectives
The present study aimed to clarify the physiological relationships between rhythmic masticatory muscle activity (RMMA) and cyclic changes in cortical, autonomic, and arousal-motor activities during sleep in sleep bruxism (SB) children.

Methods
Polysomnographic recordings were performed on 15 SB children (9 boys, 6 girls, 10.3 ± 2.5 years) and 18 control children (5 boys, 13 girls, 10.7 ± 3.1 years) free from sleep and developmental disorders. Sleep and RMMA were scored by the standard rules. Sleep cycle was divided into NREM and REM sleep segments and the frequency of RMMA, transient arousal and movement, and cortical and cardiac activities were then quantitatively analyzed in relation to sleep cycles.

Results
Neither sleep architecture nor sleep stage distribution of RMMA significantly differed between the two groups. In sleep cycles, SB children showed more frequent RMMA in all segments than controls, while cyclic changes in cortical and autonomic activities did not significantly differ between the two groups. In SB children, RMMA was the most frequent in the last NREM segment before REM sleep and was associated with increases in cortical beta activity and arousal; more than 70% of RMMA time-dependently occurred with cortical and motor arousals.

Conclusions
This is the first study to suggest that the potentiation of RMMA occurrence was associated with transient arousal under cyclic sleep processes in primary SB children.
Bee-Vectored Aureobasidium pullulans for Biological Control of Gray Mold in Strawberry
Authors: Iqbal Mudassir , Jützeler Matilda , França Soraya C. , Wäckers Felix , Andreasson Erik , Stenberg Johan A. 
Published: June 2021

Gray mold caused by Botrytis cinerea is a common postharvest disease in strawberries, reducing shelf life considerably. We investigated the potential of the yeast-like biocontrol fungus Aureobasidium pullulans (AP-SLU6) vectored by bumblebees (Bombus terrestris) in the Flying Doctors® system to inhibit the pathogen and increase the shelf life of harvested strawberries (cultivar Sonata). Using bumblebees as vectors of various biocontrol agents is becoming increasingly popular, but any potentially negative effects on bee performance have been understudied. Our results show that, over the 4-week period of the trial, the performance and activity of the bees were not negatively affected by A. pullulans. The bees successfully picked up the powder formulation; then, they carried and deposited it on the flowers. The vectoring of the biocontrol agent significantly reduced gray mold development on the harvested fruits by 45% and increased shelf life by 100% in comparison with control treatments. This suggests that the biocontrol fungus applied during flowering successfully reduced Botrytis infection and thus, effectively protected the fruits from gray mold. In addition, the bee-vectored application of the biocontrol agent was found to be significantly more effective than spray application because the latter may temporarily increase humidity around the flower, thereby creating a suitable environment for the pathogen to thrive. In summary, our study demonstrates that A. pullulans vectored by bumblebees can decrease gray mold infection and improve the shelf life of strawberries without adversely affecting the bees, thus providing a basis for the sustainable and efficient control of gray mold on strawberry. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
Turning Back the Clock: Artificial Intelligence Recognition of Age Reduction after Face-Lift Surgery Correlates with Patient Satisfaction
Authors: Zhang Ben H. , Chen Kevin , Lu Stephen M. , Nakfoor Bruce , Cheng Roger , Gibstein Alexander , Tanna Neil , Thorne Charles H. , Bradley James P. 
Published: June 2021

Background:
Patients desire face-lifting procedures primarily to appear younger, more refreshed, and attractive. Because there are few objective studies assessing the success of face-lift surgery, the authors used artificial intelligence, in the form of convolutional neural network algorithms alongside FACE-Q patient-reported outcomes, to evaluate perceived age reduction and patient satisfaction following face-lift surgery.

Methods:
Standardized preoperative and postoperative (1 year) images of 50 consecutive patients who underwent face-lift procedures (platysmaplasty, superficial musculoaponeurotic system–ectomy, cheek minimal access cranial suspension malar lift, or fat grafting) were used by four neural networks (trained to identify age based on facial features) to estimate age reduction after surgery. In addition, FACE-Q surveys were used to measure patient-reported facial aesthetic outcome. Patient satisfaction was compared to age reduction.

Results:
The neural network preoperative age accuracy score demonstrated that all four neural networks were accurate in identifying ages (mean score, 100.8). Patient self-appraisal age reduction reported a greater age reduction than neural network age reduction after a face lift (−6.7 years versus −4.3 years). FACE-Q scores demonstrated a high level of patient satisfaction for facial appearance (75.1 ± 8.1), quality of life (82.4 ± 8.3), and satisfaction with outcome (79.0 ± 6.3). Finally, there was a positive correlation between neural network age reduction and patient satisfaction.

Conclusion:
Artificial intelligence algorithms can reliably estimate the reduction in apparent age after face-lift surgery; this estimated age reduction correlates with patient satisfaction.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Diagnostic, IV.
Toward Competency-Based Training: To What Extent Are We Competency-Based?
Authors: Al-halabi Becher , Bilgic Elif , Vassiliou Melina , Gilardino Mirko 
Published: June 2021

Background:
Time-based training models in plastic surgery vary in exposure, resulting in low confidence levels among graduates. The evolution of postgraduate medical education into a competency-based model to address these issues requires an understanding of interventions described in the plastic surgery literature to identify gaps and guide creation of assessments to demonstrate competence.

Methods:
A systematic search of the MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, PubMed, and Cochrane databases from inception until December of 2017 was conducted using search terms and synonyms of educational interventions reported in plastic surgery. Full texts were retrieved following filtering and data extracted were related to intervention design and execution, involvement of competency assessment, and educational objectives and alignment to Accreditation Council for Graduate Medical Education competencies and Royal College of Physicians and Surgeons of Canada Canadian Medical Education Directives for Specialists roles. Study quality was assessed using Kirkpatrick’s levels of learning evaluation, validity evidence, and the Medical Education Research Study Quality Instrument score.

Results:
Of the initial 4307 results, only 36 interventions met the inclusion criteria. Almost all interventions aligned to medical knowledge and patient care Accreditation Council for Graduate Medical Education competencies. One-fifth of the interventions involved no assessment of competency, whereas most displayed assessment at the level of design as opposed to outcomes. Quality assessment revealed low levels of learning evaluation and evidence of validity; the average Medical Education Research Study Quality Instrument score was 10.9 of 18.

Conclusion:
A systematic review of educational literature in plastic surgery was conducted to assess the quality of reported educational interventions, and to help guide creating tools that ensure competency acquirement among trainees.
Pisa Tower Concept: A New Paradigm in Crooked Nose Treatment
Authors: Finocchi Valerio , Vellone Valentino , Ramieri Valerio , de Angelis Francesca , Marianetti Tito M. 
Published: June 2021

Background:
The primary element of a crooked nose is a midline deviation of the nasal pyramid. To date, no surgical strategies have been described as compatible with the philosophy of dorsal preservation. The dorsal preservation technique differs from the Joseph structured rhinoplasty because it preserves both the keystone area and the continuity of the cartilaginous vault. The authors focused on the versatility of the dorsal preservation technique even for the deviated nose, introducing the “Pisa Tower concept.”

Methods:
From January of 2015 to June of 2019, 280 patients diagnosed as having a crooked nose underwent primary septorhinoplasty with dorsal preservation through an asymmetric bony wedge resection and lowering of the bony pyramid onto the frontal process of the maxilla (the let-down osteotomy), in accordance with the Pisa Tower concept. Inclusion criteria were a preoperative computed tomography examination, nasal axis deviation, a complete photographic examination preoperatively, and at least a 1-year follow-up.

Results:
The mean nasal axis deviation was 7.62 degrees preoperatively and 1.15 degrees postoperatively (p < 0.05). Of the 84 patients, 47 (55.95 percent) were very satisfied, 33 (39.28 percent) were satisfied, and four (4.76 percent) were unsatisfied with surgical results and required revision surgery.

Conclusions:
The authors’ opinion is that the association of “swinging door” septoplasty with the Pisa Tower concept can be a valid alterative to other techniques when working with the structured rhinoplasty philosophy in patients with a crooked nose. Although this is only a preliminary study, the decreased use of spreaders graft and less aggressive reconstructive methods look very promising.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.
Is Nipple-Sparing Mastectomy Indicated after Previous Breast Surgery? A Series of 387 Institutional Cases
Authors: Vicini Elisa , De Lorenzi Francesca , Invento Alessandra , Corso Giovanni , Radice Davide , Bozzo Samantha , Kahler Ribeiro Fontana Sabrina , Caldarella Pietro , Veronesi Paolo , Galimberti Viviana 
Published: June 2021

Background:
Previous breast surgery does not represent an absolute contraindication for nipple-sparing mastectomy, although it may negatively interfere with surgical outcomes. The aim of the authors’ study was to confirm the feasibility of nipple-sparing mastectomy after previous breast surgery, focusing on skin incisions and risk factors, complications, and oncologic outcomes.

Methods:
The authors retrospectively identified 368 patients who underwent 387 nipple-sparing mastectomies and reconstruction after previous surgery (quadrantectomy, breast resection, augmentation and reduction mammaplasty, mastopexy) at the European Institute of Oncology from January of 2003 to November of 2017. Patterns of skin incisions (i.e., radial, hemiperiareolar, periareolar, vertical pattern, inframammary fold, Wise-pattern, and round-block) for primary surgery and for mastectomy, type of reconstruction, and radiotherapy have been recorded. The authors collected data regarding early and late complications and further operations (implant change, fat grafting) performed within 2 years to improve cosmetic outcomes. Oncologic follow-up has been reported for in-breast recurrences.

Results:
Complete and partial nipple-areola complex necrosis occurred, respectively, in 2.8 percent and in 5.4 percent of cases. The authors recorded 5.4 percent failures resulting in implant removal. The analysis of risk factors for complications or for the need for further operations showed no significant association with skin incision for first surgery and mastectomy, use of the same skin incision, previous radiotherapy, or type of primary surgery. Five-year overall survival and disease-free survival were 99.1 and 93.8 percent, respectively. No nipple recurrence was recorded.

Conclusions:
The authors’ results confirm that nipple-sparing mastectomy can be a safe surgical procedure after previous breast surgery. Surgical planning should be tailored to each patient.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.
Reduction Mammaplasty for Macromastia in Adolescents: A Systematic Review and Pooled Analysis
Authors: Hudson Alexandra S. , Morzycki Alexander D. , Guilfoyle Regan 
Published: June 2021

Background:
Reduction mammaplasty for macromastia is one of the most common operations performed by plastic surgeons. There remains hesitancy in operating on adolescents, as there is ongoing debate about breast regrowth and potential impact on breastfeeding. The goal of this study was to analyze these concerns by reviewing the current literature.

Methods:
A systematic review of MEDLINE, Scopus, and Google Scholar was conducted using the following terms: “breast reduction” or “mammaplasty” or “breast reconstruction” and “adolescent” or “youth” or “pediatric” or “child” or “teen.” Primary outcomes were success of breastfeeding after the procedure and procedure-related complications.

Results:
Twenty-three studies (87 percent retrospective), consisting of 2926 patients with preoperative cup sizes of C to KK (mean, DDD), met inclusion criteria. Mean age at the time of surgery ranged from 16 to 21 years, with the youngest patient being 12 years old. The overall complication rate was 27.3 percent (95 percent CI, 14.4 to 42.5 percent). Minor complications (22.8 percent; 95 percent CI, 10.2 to 38.5 percent) were more common than major (4.2 percent; 95 percent CI, 1.6 to 7.9 percent). Eighteen percent of patients (95 percent CI, 2.2 to 43.8 percent) reported regrowth of their breast tissue postoperatively, with 2.7 percent (95 percent CI, 0.9 to 5.5 percent) undergoing a second revision mammaplasty. Fifty-three percent of patients (95 percent CI, 36.0 to 69.3 percent) did not attempt breastfeeding. Of those who attempted, 55.1 percent (95 percent CI, 34.4 to 74.9 percent) were successful.

Conclusions:
Prospective data are lacking. Patient counseling should focus on encouraging a trial of breastfeeding, despite surgical history. One-fifth of adolescent patients may notice breast regrowth postoperatively; however, the amount of regrowth is likely small and unlikely to reexacerbate symptoms, as the rate of revision surgery is small.
Detection of Perfusion Deficits in Multiphase Computed Tomography Angiography—A Stroke Imaging Technique Based on Iodine Mapping on Spectral Computed Tomography: Initial Findings
Authors: Fransson Veronica , Mellander Helena , Wasselius Johan , Ydström Kristina 
Published: June 2021

Objective
The purpose of this study was to explore a novel method for brain tissue differentiation using quantitative analysis of multiphase computed tomography (CT) angiography (MP-CTA) on spectral CT, to assess whether it can distinguish underperfused from normal tissue, using CT perfusion (CTP) as reference.

Methods
Noncontrast CT and MP-CTA images from 10 patients were analyzed in vascular regions through measurements of Hounsfield unit (HU) at 120 kV, HU at 40 keV, and iodine density. Regions were categorized as normal or ischemic according to CTP. Hounsfield unit and iodine density were compared regarding ability to separate normal and ischemic tissue, the difference in maximum time derivative of the right over left hemisphere ratio.

Results
Iodine density had the highest maximum time derivatives and generated the largest mean separation between normal and ischemic tissue.

Conclusions
The method can be used to categorize tissue as normal or underperfused. Using iodine quantification seems to give a more distinct differentiation of perfusion defects compared with conventional HU.