bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excellent Ultracold Molecular Candidates From Group VA Hydrides: Whether Do Nearby Electronic States Interfere?
Authors: Li Donghui , Bian Wensheng 
Published: December 2021

By means of highly accurate ab initio calculations, we identify two excellent ultracold molecular candidates from group VA hydrides. We find that NH and PH are suitable for the production of ultracold molecules, and the feasibility and advantage of two laser cooling schemes are demonstrated, which involve different spin-orbit states (A3Π2 and X3Σ1− ). The internally contracted multireference configuration interaction method is applied in calculations of the six low-lying Λ-S states of NH and PH with the spin-orbit coupling effects included, and excellent agreement is achieved between the computed and experimental spectroscopic data. We find that the locations of crossing point between the A3Π and Σ−5 states of NH and PH are higher than the corresponding v′ = 2 vibrational levels of the A3Π state indicating that the crossings with higher electronic states would not affect laser cooling. Meanwhile, the extremely small vibrational branching loss ratios of the A3Π2 → a1Δ2 transition for NH and PH (NH: 1.81 × 10–8; PH: 1.08 × 10–6) indicate that the a1Δ2 intermediate electronic state will not interfere with the laser cooling. Consequently, we construct feasible laser-cooling schemes for NH and PH using three lasers based on the A3Π2 → X3Σ1− transition, which feature highly diagonal vibrational branching ratio R00 (NH: 0.9952; PH: 0.9977), the large number of scattered photons (NH: 1.04×105; PH: 8.32×106) and very short radiative lifetimes (NH: 474 ns; PH: 526 ns). Our work suggests that feasible laser-cooling schemes could be established for a molecular system with extra electronic states close to those chosen for laser-cooling.
Machine Learning for the Prediction of Complications in Patients After Mitral Valve Surgery
Authors: Jiang Haiye , Liu Leping , Wang Yongjun , Ji Hongwen , Ma Xianjun , Wu Jingyi , Huang Yuanshuai , Wang Xinhua , Gui Rong , Zhao Qinyu , Chen Bingyu 
Published: December 2021

Background: This study intended to use a machine learning model to identify critical preoperative and intraoperative variables and predict the risk of several severe complications (myocardial infarction, stroke, renal failure, and hospital mortality) after cardiac valvular surgery.Study Design and Methods: A total of 1,488 patients undergoing cardiac valvular surgery in eight large tertiary hospitals in China were examined. Fifty-four perioperative variables, such as essential demographic characteristics, concomitant disease, preoperative laboratory indicators, operation type, and intraoperative information, were collected. Machine learning models were developed and validated by 10-fold cross-validation. In each fold, Recursive Feature Elimination was used to select key variables. Ten machine learning models and logistic regression were developed. The area under the receiver operating characteristic (AUROC), accuracy (ACC), Youden index, sensitivity, specificity, F1-score, positive predictive value (PPV), and negative predictive value (NPV) were used to compare the prediction performance of different models. The SHapley Additive ex Planations package was applied to interpret the best machine learning model. Finally, a model was trained on the whole dataset with the merged key variables, and a web tool was created for clinicians to use.Results: In this study, 14 vital variables, namely, intraoperative total input, intraoperative blood loss, intraoperative colloid bolus, Classification of New York Heart Association (NYHA) heart function, preoperative hemoglobin (Hb), preoperative platelet (PLT), age, preoperative fibrinogen (FIB), intraoperative minimum red blood cell volume (Hct), body mass index (BMI), creatinine, preoperative Hct, intraoperative minimum Hb, and intraoperative autologous blood, were finally selected. The eXtreme Gradient Boosting algorithms (XGBOOST) algorithm model presented a significantly better predictive performance (AUROC: 0.90) than the other models (ACC: 81%, Youden index: 70%, sensitivity: 89%, specificity: 81%, F1-score:0.26, PPV: 15%, and NPV: 99%).Conclusion: A model for predicting several severe complications after cardiac valvular surgery was successfully developed using a machine learning algorithm based on 14 perioperative variables, which could guide clinical physicians to take appropriate preventive measures and diminish the complications for patients at high risk.
Elevated Levels of Circulating Biomarkers Related to Leaky Gut Syndrome and Bacterial Translocation Are Associated With Graves’ Disease
Authors: Zheng Dekai , Liao Huimin , Chen Shuze , Liu Xiuying , Mao Chuyin , Zhang Cangui , Meng Min , Wang Zhi , Wang Ying , Jiang Qinrui , Xue Yaoming , Zhou Lin , Chen Ye 
Published: December 2021

BackgroundA growing number of studies have found dysbiosis of the intestinal microbiota in patients with Graves’ disease (GD). The intestinal epithelial barrier serves as the first line of defense, protecting the immune system from excessive stimulation of microbiota and toxins. Most autoimmune diseases are associated with a gut barrier dysfunction (leaky gut) which allows bacterial translocation. However, to date, potential correlations between intestinal barrier dysfunction and GD have not been explored.MethodsSerum lipopolysaccharide (LPS), intestinal fatty acid-binding protein (I-FABP), zonulin, D-lactate, and diamine oxidase (DAO) were measured to assess barrier integrity in 91 patients with GD (61 initial GD and 30 euthyroid GD) and 44 healthy controls. The quality of life (QOL) of patients with GD was assessed using the thyroid-specific patient-reported outcome (ThyPRO-39) questionnaire.ResultsThe serum levels of LPS, I-FABP, zonulin, and D-lactate were significantly higher in patients with initial GD than in healthy controls. Logistic regression analysis revealed that zonulin and D-lactate were independently associated with risk for GD and circulating zonulin could effectively distinguish patients with initial GD from healthy controls. Correlation analyses showed that I-FABP, LPS, and D-lactate were positively associated with FT4 and negatively associated with TSH. In addition, circulating LPS, zonulin, and D-lactate levels were all independent predictors of TRAb levels. Moreover, higher circulating LPS levels in patients with GD were associated with more severe hyperthyroidism (higher concentrations of FT3, FT4, and TRAb and lower TSH concentrations) and worse scores of hyperthyroid and eye symptoms.ConclusionPatients with initial GD show a disrupted intestinal barrier, characterized by elevated levels of leaky gut biomarkers. Increased intestinal permeability and bacterial translocation were associated with TRAb levels and hyperthyroidism in GD. Further research is required to elucidate the underlying mechanisms.
Designing a Scoring System for Differential Diagnosis From Reactive Thrombocytosis and Essential Thrombocytosis
Authors: Shen Chih-Lung , Hsieh Tsung-Cheng , Wang Tso-Fu , Huang Wei-Han , Chu Sung-Chao , Wu Yi-Feng 
Published: December 2021

Background: Thrombocytosis is a common finding in hospitalized patients and is of two main types, essential thrombocytosis (ET) and reactive thrombocytosis (RT). It is important to distinguish the two due to increased risk of developing marrow fibrosis, acute leukemia, and thrombosis in the former. Molecular studies are the main tools to differentiate the two but are not available in all hospitals. We aimed to design a highly sensitive scoring system using routine lab data to classify thrombocytosis as essential or reactive.Methods: A total of 145 patients were enrolled in this study. Potential predictors included patient demographics and clinical laboratory parameters. Receiver operating characteristic curve analysis was used to decide the optimal cutoff level. Multivariate logistic regression with forward model selection method was performed to decide the predictors.Results: The risk scores by multivariate analysis were as follows: 1 point for WBC &gt; 13,500/μL; 2.5 points for Hb &gt; 10.9 g/dL; 3 points for platelet count &gt; 659,000/μL; and 2 points for MPV &gt; 9.3 fL. The cut off value was set as 4.5 points, and sensitivity of 91.1% and specificity of 75.8% were noted.Conclusion: In this study, we investigated lab data and developed a high-sensitivity convenient-to-use scoring system to differentiate ET from RT. The scoring system was assigned to the resulting model to make it more economical, simple, and convenient for clinical practice.
The Global, Regional, and National Burden of Psoriasis: Results and Insights From the Global Burden of Disease 2019 Study
Authors: Damiani Giovanni , Bragazzi Nicola Luigi , Karimkhani Aksut Chante , Wu Dongze , Alicandro Gianfranco , McGonagle Dennis , Guo Cui , Dellavalle Robert , Grada Ayman , Wong Priscilla , La Vecchia Carlo , Tam Lai-Shan , Cooper Kevin D. , Naghavi Mohsen 
Published: December 2021

Background: Psoriasis is a common, chronic, inflammatory, debilitating, systemic disease with a great impact on healthcare systems worldwide. As targeted therapies have transformed the therapeutic landscape, updated estimates of the Global Burden of Disease (GBD) imposed by psoriasis are necessary in order to evaluate the effects of past health care policies and to orient and inform new national and international healthcare strategies.Methods: Data were extracted from the GBD 2019 study, which collates a systematic review of relevant scientific literature, national surveys, claims data, and primary care sources on the prevalence of psoriasis. Prevalence data were combined with disability weight (DW) to yield years lived with disability (YLDs). Measures of burden at global, regional, and national levels were generated for incidence, prevalence, and YLDs, due to psoriatic disease. All measures were reported as absolute numbers, percentages, and crude and age-adjusted rates per 100,000 persons. In addition, psoriasis burden was assessed by socio-demographic index (SDI).Findings: According to the GBD 2019 methodology, there were 4,622,594 (95% uncertainty interval or UI 4,458,904–4,780,771) incident cases of psoriasis worldwide in 2019. The age-standardized incidence rate in 2019 was 57.8 (95% UI 55.8–59.7) per 100,000 people. With respect to 1990, this corresponded to a decrease of 20.0% (95% UI −20.2 to −19.8). By sex, the age-standardized incidence rate was similar between men [57.8 (95% UI 55.8–59.8) per 100,000 people] and women [(57.8 (95% UI 55.8–59.7) per 100,000 people]. With respect to 1990, this corresponded to a decrease by 19.5% (95% UI −19.8 to −19.2) and by 20.4% (95% UI −20.7 to −20.2) for men and women, respectively. The age-standardized incidence rate per 100,000 persons was found to vary widely across geographic locations. Regionally, high-income countries and territories had the highest age-standardized incidence rate of psoriasis [112.6 (95% UI 108.9–116.1)], followed by high-middle SDI countries [69.4 (95% UI 67.1–71.9)], while low SDI countries reported the lowest rate [38.1 (95% UI 36.8–39.5)]. Similar trends were detected for prevalence and YLDs.Conclusion: In general, psoriasis burden is greatest in the age group of 60–69 years, with a relatively similar burden among men and women. The burden is disproportionately greater in high-income and high SDI index countries of North America and Europe. With advances in psoriasis therapeutics, objective evaluation of psoriasis disease burden is critical to track the progress at the population level.
Proximity to Heavy Traffic Roads and Patient Characteristics of Late of Onset Asthma in an Urban Asthma Center
Authors: Lin Ting-Yu , Lin Horng-Chyuan , Liu Yun-Sheng , Lo Yu-Lun , Wang Chun-Hua , Chang Po-Jui , Lo Chun-Yu , Lin Shu-Min 
Published: December 2021

Background: Traffic-related pollution is associated with the onset of asthma and the development of different phenotypes of asthma. Few studies have investigated the association between traffic proximity and late-onset of asthma (LOA) and early-onset asthma (EOA). This study was conducted to investigate the associations of LOA phenotypes with a function of the distance between residence and heavy traffic roads (HTRs).Methods: The study group consisted of 280 patients who were (LOA: 78.4%) recruited consecutively from a pay-for-performance asthma program to clarify the patient characteristics and proximity to HTRs within 1,000 m from their residences between EOA and LOA in three urban centers in Taiwan. The subsequent analysis focused on patients with LOA (n = 210) linking phenotypes and distance to HTRs.Results: Subjects with LOA tended to be older than those with EOA and had shorter asthma duration, poorer lung function, lower atopy, and less exposure to fumes or dust at home. Patients with LOA were more likely than those with EOA to live within 900 m of two or more HTRs (14.3 vs. 3.4%, p = 0.02). Among patients with LOA, minimum distance to an HTR was negatively associated with numbers of specific IgE as well as positively associated with the age of onset and body weight significantly. A higher proportion of patients with atopy (26.3 vs. 20.6%, p = 0.001. odds ratio [OR]: 2.82) and anxiety/depression (21.0 vs. 18.1%, p = 0.047. OR: 1.81) and a trend of lower proportion of patients with obese (5.7 vs. 12.4%, p = 0.075) were found to be living within 900 m from HTRs.Conclusions: Late-onset of asthma (LOA) tended to live in areas of higher HTR density compared to EOAs. Among patients with LOA living close to HTRs, the interaction between traffic-related pollution, allergy sensitization, and mood status were the factors associated with asthma onset early. Obesity may be the factor for later onset who live far from HTRs.
Cerebral Revascularization for the Management of Symptomatic Pure Arterial Malformations
Authors: Lu Xiaocheng , Fang Xinggen , Huang Yabo , Zhou Peng , Wang Zhong , Brinjikji Waleed , Chen Gang 
Published: December 2021

Background: Pure arterial malformations (PAMs) are extremely rare abnormalities defined as dilated, overlapping, and tortuous arteries with a coil-like appearance in the absence of venous components. Over the last half century, only seven published reports have described cases of patients with PAMs who received treatment.Methods: Here, we report two cases of women with PAMs who received surgical treatment, and we present a systematic review of the literature. We searched the PubMed, Embase, Web of Science, and Medline databases (up until October 1, 2021) for relevant publications. We performed independent-sample t-tests and Fisher's exact tests to compare continuous and categorical characteristics among the available cases.Results: Our first patient was a 43-year-old woman with PAM of the left internal carotid artery (ICA), who received an ICA-radial artery (RA)-M2 bypass. Post-operative digital subtraction angiography (DSA) revealed the disappearance of the left ICA PAM without ischemic events during follow-up. The second patient was a 53-year-old woman with PAMs of the right ICA and posterior cerebral artery. The P1 lesion was treated by proximal occlusion combined with a superficial temporal artery-P2 bypass. During the 12-month follow-up period, the size of the PAMs decreased significantly as indicated by the post-operative DSA showing the absence of hemorrhages. Our systematic review, which includes 56 PAMs, shows that the reported PAMs were more common in the anterior circulation (33/56, 58.9%) than in the posterior circulation (11/56, 19.7%). Bilateral PAMs were more likely to affect bilateral anterior cerebral arteries (ACA) (ACAbilateral vs. ACAunilateral: 63.6 vs. 26.2%, p = 0.02). In addition, PAMs involving the anterior circulation were likely to affect multiple arteries (anteriormulti vs. posteriormulti: 30.3 vs. 0%, p = 0.038).Conclusion: We found very few reports on treated PAMs; further studies with large sample sizes and long follow-up periods are required to explore the appropriate treatment strategy for PAMs.
Phase I Clinical Trial of an Autologous Dendritic Cell Vaccine Against HER2 Shows Safety and Preliminary Clinical Efficacy
Authors: Maeng Hoyoung M. , Moore Brittni N. , Bagheri Hadi , Steinberg Seth M. , Inglefield Jon , Dunham Kim , Wei Wei-Zen , Morris John C. , Terabe Masaki , England Lee C. , Roberson Brenda , Rosing Douglas , Sachdev Vandana , Pack Svetlana D. , Miettinen Markku M. , Barr Frederic G. , Weiner Louis M. , Panch Sandhya , Stroncek David F. , Wood Lauren V. , Berzofsky Jay A. 
Published: December 2021

BackgroundDespite recent advances, there is an urgent need for agents targeting HER2-expressing cancers other than breast cancer. We report a phase I study (NCT01730118) of a dendritic cell (DC) vaccine targeting HER2 in patients with metastatic cancer or bladder cancer at high risk of relapse.Patients and MethodsPart 1 of the study enrolled patients with HER2-expressing metastatic cancer that had progressed after at least standard treatment and patients who underwent definitive treatment for invasive bladder cancer with no evidence of disease at the time of enrollment. Part 2 enrolled patients with HER2-expressing metastatic cancer who had progressed after anti-HER2 therapy. The DC vaccines were prepared from autologous monocytes and transduced with an adenoviral vector expressing the extracellular and transmembrane domains of HER2 (AdHER2). A total of five doses were planned, and adverse events were recorded in patients who received at least one dose. Objective response was evaluated by unidimensional immune-related response criteria every 8 weeks in patients who received at least two doses. Humoral and cellular immunogenicity were assessed in patients who received more than three doses.ResultsA total of 33 patients were enrolled at four dose levels (5 × 106, 10 × 106, 20 × 106, and 40 × 106DCs). Median follow-up duration was 36 weeks (4–124); 10 patients completed five doses. The main reason for going off-study was disease progression. The main adverse events attributable to the vaccine were injection-site reactions. No cardiac toxicity was noted. Seven of 21 evaluable patients (33.3%) demonstrated clinical benefit (1 complete response, 1 partial response, and 5 stable disease). After ≥3 doses, an antibody response was detected in 3 of 13 patients (23.1%), including patients with complete and partial responses. Lymphocytes from 10 of 11 patients (90.9%) showed induction of anti-HER2 responses measured by the production of at least one of interferon-gamma, granzyme B, or tumor necrosis factor-alpha, and there were multifunctional responses in 8 of 11 patients (72.7%).ConclusionsThe AdHER2 DC vaccine showed evidence of immunogenicity and preliminary clinical benefit in patients with HER2-expressing cancers, along with an excellent safety profile. It shows promise for further clinical applications, especially in combination regimens.
Assessment of Counseling Self-Efficacy: Validation of the German Counselor Activity Self-Efficacy Scales-Revised
Authors: Hahn Daniela , Weck Florian , Witthöft Michael , Kühne Franziska 
Published: December 2021

Background: Many authors regard counseling self-efficacy (CSE) as important in therapist development and training. The purpose of this study was to examine the factor structure, reliability, and validity of the German version of the Counselor Activity Self-Efficacy Scales-Revised (CASES-R).Method: The sample consisted of 670 German psychotherapy trainees, who completed an online survey. We examined the factor structure by applying exploratory and confirmatory factor analysis to the instrument as a whole.Results: A bifactor-exploratory structural equation modeling model with one general and five specific factors provided the best fit to the data. Omega hierarchical coefficients indicated optimal reliability for the general factor, acceptable reliability for the Action Skills-Revised (AS-R) factor, and insufficient estimates for the remaining factors. The CASES-R scales yielded significant correlations with related measures, but also with therapeutic orientations.Conclusion: We found support for the reliability and validity of the German CASES-R. However, the subdomains (except AS-R) should be interpreted with caution, and we do not recommend the CASES-R for comparisons between psychotherapeutic orientations.
RUSSIAN DRAMA DURING THE CRIMEAN WAR OF 1853–1856
Authors: Patrikeeva Mariya V. 
Published: December 2021

The Crimean War of 1853–1856 became a real challenge for Russian society and was reflected in the culture and art of
that time, including drama. Already during the war, plays dedicated to this historical event were being created and staged in
theatres. This article analyses four plays – “For the Faith, the Tsar and the Fatherland” by Pyotr Grigor’yev, “The Veteran and
the Recruit” by Aleksey Pisemsky, “The Feat of the Mother” by Orest Miller, “The Russians in 1854” by Adelaida Tal’tseva.
The general ideological message of those dramatic works included patriotism, glorification of the greatness of the Fatherland
and the strength of the Russian people, the Orthodox faith, in connection with which the plays created the image of a
Russian soldier for whom participation in the war is a matter of honour and faith. The study establishes the correspondence
of dramatic works of the period of the Crimean War of 1853–1856 to the requirements of the time, their close connection
with the historical context of the era, as well as an orientation towards ease of perception by the audience. The author of
the article defines the general features of patriotic plays of the Crimean War period at the plot and ideological level.
ƯỚC LƯỢNG TRONG MÔ HÌNH HỒI QUI POISSON GIÃN NỞ SỐ KHÔNG KIỂM DUYỆT BÊN PHẢI
Authors: Trịnh Nguyễn Văn , Minh Phạm Văn 
Published: December 2021

Dữ liệu đếm thường xuất hiện trong nhiều lĩnh vực thực tế như y tế, kinh tế, dịch tễ học... Để xử lý loại dữ liện này, nhiều mô hình hồi quy đã phát triển như hồi quy Poisson, hồi quy Nhị thức hay tổng quát hơn là mô hình hồi quy tổng quát hóa (GLMs). Khi dữ liệu đếm chứa nhiều số không, các mô hình giãn nở số không (ZI) ra đời. Tuy nhiên nếu dữ liệu cần kiểm duyệt thì các mô hình trên không còn phù hợp. Vì vậy, Saffar i and Adnan (2001) đã đề cập đến mô hình này bằng nghiên cứu mô phỏng đơn giản. Tuy nhiên, tác giả chưa chứng minh cho sự tồn tại, tính vững và tính tiệm cận chuẩn của đại lượng hợp lí cực đại (MLE). Với nhận định đó, bài báo này phát tr iển lý thuyết đưa ra chứng minh chặt chẽ cho các vấn đề trên dựa vào lý thuyết tiệm cận chuẩn.
TRACKING CONTROL OF WHEELED MOBILE ROBOT WITH MODEL UNCERTAINTIES AND INPUT DISTURBANCE: A NOVEL APPROACH WITH DISTURBANCE ESTIMATION AND ARBITRARY CONVERGENCE TIME CONTROLLER
Authors: Nam Nguyễn Hoài , Quỳnh Lê Ngọc , Minh Phạm Tuấn Nhật 
Published: December 2021

Xe tự hành đã được sử dụng rộng rãi trong thực tế và chúng thu hút được nhiều sự quan tâm từ những nhà nghiên cứu do tính ràng buộc không tích phân được, tính phi tuyến và tải bất định của chúng. Trong bài báo này một phương pháp điều khiển bám mới được đề xuất cho xe tự hành với mô hình bất định và có nhiễu đầu vào. Phương pháp mới này dựa trên một bộ quan sát nhiễu đầu vào và bộ điều khiển có thời gian đáp ứng tùy ý. Bất định của mô hình và nhiễu đầu vào sẽ được bù bằng bộ quan sát nhiễu trong khi đó sai lệch tốc độ sẽ tiến đến không trong một khoảng thời gian xác lập cho trước bởi bộ điều khiển thời gian hữu hạn tùy ý, bộ điều khiển này sẽ cải thiện chất lượng điều khiển của hệ kín. Tính hiệu quả của phương pháp được kiểm chứng thông qua mô phỏng số.