bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Amniotic Mesenchymal Stem Cells Inhibit aGVHD in Humanized Mice by Regulating the Balance of Treg and T Effector Cells
Authors: Gao Ya , Li Wei-Ru , Bu Xiao-Yin , Xu Ying , Cai Sheng-Chun , Zhong Jin-Man , Du Mei-Xue , Sun Hai-Tao , Huang Li-Ping , He Yong-Jian , Hu Xiu-Mei , Liu Qi-Fa , Jin Hua , Wang Qian , Ping Bao-hong 
Published: June 2021

Abstract
Background: Acute graft versus host disease (aGVHD) remains a leading cause of transplant-related mortality following allogeneic haematopoietic cell transplantation(allo-HCT). Although previous studies indicated that mesenchymal stem cells (MSCs) may be a salvage therapeutic agent for aGVHD, the mechanism is not yet fully clear. Human amniotic mesenchymal stem cells (hAMSCs) is a novel MSCs, compared with bone marrow mesenchymal stem cells, it has the advantage of being non-invasive, and also has stronger proliferation ability than that of BM-MSCs and equivalent immune regulation ability as BM-MSCs. The aim of this study was to explore the therapeutic efficacy and underlying mechanisms of human amniotic mesenchymal stem cells transplantation for the humanized aGVHD mouse model.Methods: We established a humanized aGVHD mouse model by transplanting human peripheral blood mononuclear cells (PBMCs) into NOD-PrkdcscidIL2rγnull (NPG) mice, hAMSCs collected from discarded placenta of healthy pregnant women after delivery. Mice were divided into control group (untreated), aGVHD group, and hAMSCs treatment group, the hAMSCs labeled with GFP were administered to aGVHD mice to explore the homing ability of hAMSCs. T effector and Treg cell levels and cytokines of each group in target organs were detected by flow cytometry and cytometric bead array (CBA) respectively.Results: We successfully established a humanized aGVHD mouse model using NPG mice. The hAMSCs have the ability to inhibit aGVHD in this mouse model through reduced villous blunting and lymphocyte infiltration into the lamina propria of the gut while reducing vascular endothelialitis and lymphocyte infiltration into the parenchyma of the liver and lung. hAMSCs suppressed xenogenesis CD3+CD4+ T and CD3+CD8+ T cell expression and increased the proportion of Treg cells, and besides, hAMSCs can reduce the levels of IL-17A, INF-γ, TNF, and IL-2 in aGVHD target organs.Conclusions: The NPG murine environment was capable of activating human T cells to produce aGVHD pathology to mimic aGVHD as in humans. The hAMSCs controlled aGVHD by decreasing inflammatory cytokine secretion within target organs by modulating the balance of Treg and T effector cells in humanized mice.
Construction of a Competitive Endogenous RNA Network Associated with Angiogenesis in Ischemic Stroke Using a Bioinformatics Approach
Authors: Wang Jia , Zhang Xuxiang , Xie Yibo , Li Jiachen , Wang Xiaokun , yang chunxiao 
Published: June 2021

Abstract
Ischemic stroke (IS) is one of the leading causes of death and disability worldwide, and angiogenesis is an important target for its treatment. However, the mechanism of angiogenesis of endogenous RNA (ceRNA) in IS remains poorly understood. This study aims to explore the role of ceRNA in the angiogenesis of IS, to provide a possible target for the treatment of IS. First, GSE22255 (mRNA), GSE55937 (miRNA) and GSE102541 (lncRNA) were downloaded from the Gene Expression Omnibus (GEO) database. Then, a total of 21 mRNA modules were identified by WGCNA analysis, among which NR4A1, PTGS2, ERG3, and VEGFA in cyan module were identified as key genes for angiogenesis. Subsequently, 1454 differentially expressed lncRNAs (DELs) were screened and a lncRNA-mRNA co-expression network consisting of 40 lncRNAs and 4 mRNAs was constructed by correlation analysis. Then, 16 differentially expressed miRNAs (DEMs) were screened and the online database was used to predict the interaction information between miRNAs, lncRNAs and mRNAs. The angiogenesis-related ceRNA network was finally constructed based on ceRNA theory, in which 1 DEL was predicted as a ceRNA for 2 DEMs to regulate 4 hub genes, specifically, HCG18-has-let-7i-5p-NR4A1/PTGS2/ERG3, HCG18-miR-148a-3p-PTGS2/ERG3/VEGFA interaction axis. The results of gene set enrichment analysis (GSEA) suggest that HCG18 may regulate angiogenesis through NF-kB-TNFA signaling pathway, hypoxia and other pathways. In conclusion, the above genes may be new biomarkers and potential targets for the treatment of IS.
Joint Analysis as an Important Tool for an Optimizing Block Extraction of Natural Stones
Authors: Schneider-Löbens Christiane , Siegesmund Siegfried , Stein Karl-Jochen , Lebens Stefan 
Published: June 2021

Abstract
The steadily increasing demand on the natural stone market is accompanied by a predominantly poor economic balance in the extraction of the raw material "ornamental stone". Thus, the net production of raw blocks is far too low in relation to the resulting overburden, which is often the result of insufficient geoscientific input and evaluation of the deposit itself and the deposit-controlling factors.Under these conditions, the investigation pursued the goal of capturing an essential part of the geological conditions with the analytical observation of the fractures systems, in order to contribute to an optimized stone extraction. Only by critically derived constraints on the quarrying process based on the geological situation can the economic viability of natural stone deposits be maintained or increased in the long term, and this from an environmentally friendly point of view.Profitable dimensional stone production mainly depends on the number of extracted blocks. Compared to statistical approaches the application of the 3D-BlockExpert computer code is based on modelling the block sizes on the discontinuity system such as fracture spacing and fracture orientation. The assessment of all joint and fracture systems provides a forwards-looking approach for sustainable quarry management. It is essential to make the best possible use of high-quality material and to minimize the impact of quarrying activities to nature. Investigations were carried out in quarry areas of different lithologies in Germany and Spain like sandstones, limestones, slate and granites. The block sizes, the irregularity of acute-angled blocks and the waste to block ratio controls the economic success by avoiding time- and cost-consuming procedures based on geoscientific considerations.
Response of Lupinus bracteolaris seeds to pre-germinative treatments and experimental conditions
Authors: Pinto Paim Luciana , Demari Avrella Eduarda , Carolina Alves Horlle Juliana , Sidnei Fior Claudimar , Lazarotto Marília , Pich Brunes André 
Published: June 2021

Contextualization: Lupinus bracteolaris is a heliophite species that vegetates low lands, open slopes and sandstone hills.
Knowledge gap: Despite the high rusticity and potential for covering poor soils, there is still no information to assist in the analysis of its seeds.
Purpose: To determine pre-germinative treatments, substrate, temperature, luminosity and water intake in the vigor of Lupinus bracteolaris seeds.
Methodology: Fruits were collected from 20 matrix plants, then the seeds were processed and submitted to the following tests: pre-germinative methods (six treatments at 25°C); substrates and temperatures (sand and paper at 20, 25 and 30°C); photoblast test (white light, diffuse-green light and continuous dark under 20°C) and the imbibition curve (control and scarification between sandpaper under 20°C). Evaluations: percentage of germination and formed seedlings, germination speed index, average germination time and seedling formation, using a completely randomized design.
Results and conclusions: According to the analyzed variables, the results showed superiority for the pre-germinative treatment between sandpapers for 20 seconds. In addition, the substrate paper germibox and the temperature of 20°C were the most suitable during seed germination. The seeds of Lupinus bracteolaris were classified as neutral-photoblastic and without dormancy.
Pendugaan umur simpan coklat instan kemasan plastik polipropilen menggunakan pendekatan model Arrhenius [Shelf life prediction of instant chocolate in poly propylene (PP) plastic packaging using Arrhenius model approach]
Authors: Hidayati Sri , Sartika Dewi , Suharyono Suharyono , Sutoyo Sutoyo 
Published: June 2021

The research aimed to predict instant chocolate's shelf life using the Accelerated Shelf Life Test (ASLT) method with the Arrhenius equation. Instant chocolate was stored at 30oC, 40oC, and 50oC in polypropylene plastic packaging for 42 days and observed changes in water content, free fatty acids, and aroma. The results showed an increase in temperature and storage time resulted in an increase in moisture and FFA content but decreased the aroma score of instant chocolate stored using polypropylene packaging. Shelf life estimates were based on free fatty acids and first-order reactions. The shelf life of instant chocolate stored at 30oC was 214 days, at 40oC was 140.79 days, and at 50oC condition was 113 days.
Therapeutic efficacy of Albendazole and Mefloquine alone or in combination against early and late stages of Trichinella spiralis infection in mice
Authors: Fahmy A. M. , Diab T. M. 
Published: June 2021

Summary
This study aimed to determine the effectiveness of mefl oquine alone or combined with albendazole in reduced doses against T. spiralis infection. One hundred and twenty albino mice were orally infected with 200 T. spiralis larvae/mouse. Drugs were administered during the enteral phase on days 1 to 3 and on the chronic phase on days 35 to 37 post-infection, and mice were sacrificed, respectively, at days 7 or 48 post-infection to count mature intestinal worms or encysted muscle larvae. The effect of the treatment on the histology of the target organs of each phase, intestine and diaphragm, was also evaluated. A signifi cant decrease in intestinal worms was found in all treated groups relative to the untreated control group at a peak of 93.7% in the combination albendazole-mefl oquine group. Results in all treated groups demonstrated a signifi cant decrease in muscle larvae relative to untreated control groups, achieving 86.2 % in the combined albendazole-mefl oquine group. There was a marked improvement in the intestinal and muscular architecture in all treated groups compared to the non-treated control group. Notably, the albendazole-mefl oquine group showed an almost complete recovery. The combined albendazole-mefl oquine low dose regimen had the highest effect on reducing parasite burden and restoring normal histological architecture.
Personal Hygiene and Knowledge as a Typhoid Fever Risk Factor in Muna City Hospital
Authors: Fitriani Fitriani , Sukmana Mayusef 
Published: June 2021

Data from WHO, the incidence thypoid fever in the world at 16- 33 millions with 500-600 thousand mortalities every year. Data from the Hospital District Muna year in 2013 amounted to 98 cases, while in 2014, the incidence of typhoid fever from january-april of 39 cases with 78 patients with fever. This study aims to determine the effect of knowledge and personal on the incidence of typhoid fever in hospitals Kab.Muna. This type of research is an analytic study with case-control design.. Number of samples in this study were as many as 78 people with the criteria of the sample is 39 cases and 39 controls were drawn from 78 population. The data were processed using univariate, bivariate, and odds ratio test. From the results of the study showed no significant effect between the knowledge of the value of OR = 2.671, the lower limit and upper limit = 0.830 = 8.603. With the value of personal hygiene OR = 2.170, the lower limit and upper limit = 0.786 = 5.993. Increased knowledge and awareness through counseling patients and healthy hygienic behavior is needed for prevention and control of typhoid fever occurrence in Muna District Hospital. Keywords: Knowledge , Personal Hygiene and typhoid fever.
The Effectiveness of the Water Tepid Sponge to Decrease the Body Temperature in Children With Febrile Seizure
Authors: Faradilla Fera , Abdullah Rusli 
Published: June 2021

Abstract Background: Fever belongs to one of the triggers that resulted in febrile seizures. One of the actions of the non-pharmacological can be given to lower the body temperature in children with febrile seizure is the act of water tepid sponge. Purpose: this literature Review aims to analyze the effect of the adoption of the act water tepid sponge to decrease the body temperature in children who experienced febrile seizures. Methods: this Study explores quantitative evidence, published in electronic database such as Pubmed, Google Scholar, and Science Direct. With the use of search strategies, the researcher identified 39 articles that are potentially relevant to the purpose of the research, and 1 article included in the final analysis. Results: We can see a significant effect of decrease in body temperature in the group given the intervention water tepid sponge than a group of warm compresses. Conclusion: this Study shows that the actions of the water tepid sponge effective in lowering body temperature in children with febrile seizure. Keyword : Body temperature; Febrile seizures; Water tepid sponge.
The production risk of broiler farm management at plasma breeders: Evidence from Indonesia
Authors: Suwarta Suwarta , Hanafie Rita 
Published: June 2021

The broiler chicken business is essential to providing national meat consumption in Indonesia. However, the business also faces a very significant management risk. The purpose of this research is to study broiler farm management and the effect of its business management on the production and production risk. This research was conducted in Lamongan regency of East Java by interviewing broiler chicken farmers and using descriptive and multiple linear regression analysis. The results of the research show that the implementation of broiler farm management reached 73.48% of ideal situation, with planning reaching 67.64% ideal situation, 65.58% for ideal organizing, 84.18% for optimal direction, 74.43% for ideal coordination, and 77.58% for ideal control. Also, the management had a positive influence on the production of the broiler livestock business, with an elasticity of 0.700. The management had a negative effect on the risk of production of broiler livestock business with the elasticity of 0.237. Production risk was negatively affected by the number of chicks and the amount of feed. To provide support for breeders in their business, it is necessary to have a policy of low cost of broiler cultivation, especially the cost of chicks and feed, by setting DOC prices and cheap or cheaper feed. Besides, it is required to develop cooperation with companies using broiler primary products, as well as certain policies so that there will be businesses that use broiler primary products as their main ingredient.JEL Classification D13; Q02; Q12
Household finances and social comparison: Determinants of financial well-being in Indonesia
Authors: Ghina Aisyah Amatul , Sukarno Subiakto 
Published: June 2021

To achieve a vision of sustainable financial well-being (FWB) in Indonesia, generating more knowledge in household behavior and FWB is pivotal. This study assesses the impact of household financial position and social comparison on individual FWB in Indonesia. Using the latest wave of Indonesia Family Life Survey (IFLS) dataset, subjective FWB assessed by questions on subjective prosperity, perceived current standard of living adequacy and perceived future standard of living. The empirical analysis shows that net wealth and total assets are also essential determinants and positively related to FWB along with income. On the contrary, though it is only found significant on the perceived current standard of living adequacy, the total debt level has a negative effect on FWB. The findings also confirm that socioeconomic and demographic factors also significantly affect FWB (e.g., being female and more educated has a positive effect on FWB). Furthermore, it also found that relative financial position (i.e., social comparison) has important roles in determining individuals' FWB level. Being above the reference group's average for a particular financial measure (i.e., income and total assets) has a positive effect on an individual's FWB. The findings of this study suggest for promoting financial education in the national school system starting senior high school to increase the level of financial well-being among young adult and people with lower educational attainment.JEL Classification C31; D14; I31
KONTRARADIKALISME: PERSPEKTIF KURIKULUM PAI
Authors: Azami Tomi 
Published: June 2021

Beragam kekerasan baik fisik maupun verbal mengatasnamakan agama masih marak di Indonesia. Masyarakat minoritas kerap menjadi korban. Melihat hal tersebut, tidak hanya represif yang dilakukan, namun perlu upaya preventif untuk mengatasi permasalahan ini. Kurikulum Pendidikan Agama Islam (PAI) di sekolah dapat menjadi corong dalam mengambil peran ini. Kurikulum sebaiknya dikembangkan ke arah kontraradikalisme. Artikel ini merupakan hasil penelitian kepustakaan atau riset literatur, Pengumpulan data berupa data-data kepustakaan baik berupa buku, manuskrip, jurnal, maupun sumber-sumber berbentuk dokumentasi lainnya.
Hasil penelitian menunjukkan upaya preventif dalam melakukan kontraradikalisme melalui jalur pendidikan. Pendidikan dapat menjadi senjata dalam mengonter radikalisme. Tataran praktisnya tercermin pada kurikulum PAI yang dikembangkan. Hal yang perlu digarisbawahi adalah definisi kurikulum memiliki jangkauan yang luas (tujuan, materi, strategi, media, dan evaluasi), kegiatan intrakulikuler dan ekstrakulikuler.
I cinquant'anni della Pac e il suo futuro
Authors: Bianchi Daniele 
Published: June 2021

- It has been qualified as a quiet or silent revolution, a revolution that European farmers have lived from the post-war period, the revolution that the CAP has brought into the agriculture world at European and International level. Since then, the role of agriculture in national economies has changed substantially and with it the very foundations of agriculture and agricultural policy. Since the end of 2007, how many front pages were devoted to agriculture? The significant increase in prices of agri-food products, the food versus fuel, the use of biotechnology, food fraud, speculation all these issues refocus attention on agriculture. But regardless of the breaking news, this is also the sign of the new role that agriculture plays since a long time. The farmer no longer produces food. The job of a farmer has become more complex. After having quickly recalled the evolution and achievements of fifty years of agricultural policy, attention will be particularly dedicated to the health check of PAC done in 2008, in the context (rectius different contexts) in which CAP will be called to operate in view of 2013 - end of the budget period - and, mainly, in view of the post 2013. After having analysed the procedural innovations that the Lisbon Treaty introduces into the 2003 CAP reform, we will tackle the long-lasting issue of CAP funding in the persistent global economic crisis and in a context of multilateral negotiations stalling. And in particular, we will wonder how the current single payment scheme in close cooperation with the second pillar (rural development) and with the flexibility tools introduced in the health check can provide an answer to the perennial question of justification for Community support to farmers.Parole chiave: Politica agricola comune (Pac), Health check, Trattato di Lisbona, futuro della Pac.Key words: Common Agricolture Policy (CAP), Health Check, Lisbon Treaty, Future of CAP.
Rischio ambientale e rischio alimentare: il ruolo della ricerca biotecnologica nella costruzione della sicurezza sociale
Authors: Buccioni Rossano 
Published: June 2021

- An instrument for the control of the complexity that is now regaining favour is the redefinition of "rules". The purpose of this redefinition contains a second one in itself: to establish in general if a public Ethic is necessary. The typically polemic expectation, that request of rules emerges on, pertains to the field of both private and public ethic. At the general request of ethically connoted rules, to be meant as an indicative strategy of the action in a horizon of foreseeable risks, corresponds a much widespread awareness that a complex society must rest on the thesis of the Normal Accident, that is, of a normalization of the loss, both human and material. In fact: the normal loss, above all, means a normalization of human loss. The reappearance of the questions that have always followed mankind, now surprise the ethic spring of rules in a phase of disconcerting improbability. The great seasons of moral control of the rapidly increasing social complexity today (for instance Jesuitical casuistry), reintroducing the "moral" fluid medium, show a great weakness. The socio-structural insubstantiality of Ethic shows both the strength and the topicality of the anthropological change we are living, as well as the need to be furnished of instruments of analysis of the human that set aside the scantiness of old mechanical analogies. If the complex society applied only the 40% of the biblical motto "Don't do onto others what you wouldn't like to be done to you", this society (ours) couldn't exist the way it is. Man is no longer the criterion of reference of human actions.Parole Chiave: autoreferenza, complessitĂ , concetto di societĂ , norma sociale, teoria dei sistemi sociali, rapporto tra sociologia ed etica, Codice della Morale.Key Words: Self-reference, Complexity, The Concept of Society, Social Norm, Social System Theory, Evolution of Complexity, Relationship of Sociology and Ethics, The Code of the Moral.
QualitĂ e competitivitĂ nelle produzioni agroalimentari. Le indicazioni geografiche tra esigenze di coerenza e di efficacia
Authors: TrapĂ¨ Ilaria 
Published: June 2021

Il saggio - dopo aver descritto come nel percorso storico dell'alimentazione mondiale si stia configurando sempre di piĂą la ricerca di cibi di qualitĂ e, all'interno di questi, un "ritorno agli apprezzamenti antichi" - analizza la disciplina comunitaria delle indicazioni geografiche, valutandone, in particolare, la coerenza e l'efficacia. Le indicazioni geografiche devono perseguire anche fini di trasparenza del mercato, dovendo consentire ai consumatori di effettuare scelte consapevoli ma, nella prospettiva di un approccio piĂą flessibile all'origine, tale obiettivo risulta realizzato in via eventuale ed indiretta, non potendosi escludere il rischio di confusione o di errore del consumatore. Questo potrĂ essere evitato solo attraverso una lettura congiunta e coordinata delle discipline di settore. Il legislatore deve agire con regole coerenti ed efficaci che, qualificando l'intera filiera, realizzino non solo una compiuta e corretta comunicazione sul mercato, ma tutelino l'affidamento del consumatore in ordine alle qualitĂ del prodotto.
La valutazione di incidenza come ulteriore possibile fattore di sviluppo ed occupazione nella tutela della biodiversitĂ
Authors: Benozzo Matteo 
Published: June 2021

La valutazione di incidenza come ulteriore possibile fattore di sviluppo ed occupazione nella tutela della biodiversitĂ , Matteo Benozzo Nell'Unione Europea, la biodiversitĂ ha acquistato dignitĂ di occupazione lavorativa e fattore di sviluppo, cosĂ¬ come la sua tutela implementa l'economia. Un potenziale ulteriore fattore di crescita si ritiene possa essere rappresentato dall'attuazione a livello locale della procedura di valutazione di incidenza per le aree "Natura 2000". Questo lavoro esaminerĂ la disciplina relativa a siffatta procedura, valutandone le possibili ricadute sul tessuto produttivo territoriale in termini di sviluppo ed occupazione.