bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large1 Gene Transfer in Older myd Mice with Severe Muscular Dystrophy Restores Muscle Function and Greatly Improves Survival
Authors: Yonekawa Takahiro , Rauckhorst Adam J. , El-Hattab Sara , Cuellar Marco A. , Venzke David , Anderson Mary E. , Okuma Hidehiko , Pewa Alvin D. , Taylor Eric B. , Campbell Kevin P. 
Published: October 2021

ABSTRACTMuscular dystrophy is a progressive and ultimately lethal neuromuscular disease due to lack of therapeutic options that restore muscle function. Gene editing and gene transfer hold great promise as therapies for various neuromuscular diseases when administered prior to the onset of severe clinical symptoms. However, the efficacy of these strategies for restoring neuromuscular function and improving survival in the late stages of muscular dystrophy with severe muscle pathophysiology is unknown. Dystroglycanopathies are muscular dystrophies characterized by extensive skeletal muscle degeneration and, in many cases, are accompanied by eye and brain abnormalities. Thus far, mutations in at least eighteen human genes are known to cause dystroglycanopathies, including those in the like-acetylglucosaminyltransferase-1 (LARGE1) gene. LARGE1 encodes a xylosyl- and glucuronosyltransferase that modifies α-dystroglycan (α-DG) with matriglycan, a linear repeating disaccharide of alternating xylose and glucuronic acid that binds to the laminin G-like domains of extracellular matrix proteins with high affinity. Largemyd/Largemyd (myd) mice lack expression of Large1, and exhibit severe skeletal muscle pathophysiology, impaired mobility, and a drastically reduced lifespan (50% survivorship at 35 weeks of age). Here, we show that systemic delivery of AAV2/9 CMV Large1 (AAVLarge1) in >34-week-old myd mice with advanced disease restores matriglycan expression, attenuates skeletal muscle pathophysiology, improves motor and respiratory function, and normalizes systemic metabolism, which collectively and dramatically extends survival. Our results demonstrate that in a mouse model of muscular dystrophy, skeletal muscle function can be restored, illustrating its remarkable plasticity, and that survival can be greatly improved even after the onset of severe skeletal muscle pathophysiology.
Pandemic, risk-adaptation and household saving: evidence from China
Authors: Zhang Yixing , Lu Xiaomeng , Yin Haitao , Zhao Rui 
Published: October 2021

PurposeScholars have not agreed with each other on how people would behave after experiencing a catastrophic event. They could save more as a precautionary action for future difficulties or save less with a carpe diem attitude. This study aims to attempt to shed light on this debate with empirical observations on how the Covid-19 pandemic has affected household saving decisions.Design/methodology/approachThe two waves of the survey data allowed us to investigate both instantaneous and ongoing effects of Covid-19 on household saving decisions. The instantaneous effect refers to the immediate impact of the crisis, while the ongoing effect refers to the lasting impact of the pandemic when economic recovery had started. The variation in the number of confirmed cases across cities during the two waves provides the source of power for identification. The authors extend their analyses of the impact of Covid-19 on the household saving decision by using ordinary least squares models. Due to the ordered nature of survey responses, the authors also rerun all baseline models using the ordered probit regression method.FindingsThis paper studied the impact of the Covid-19 pandemic on household saving decisions in China. This study found that households in the most affected cities would save more during the Covid-19 but tend to save less when the disaster started fading away. Combining findings in Kun et al. (2013) and Filipski et al. (2015), people do become more pessimistic during and after the Covid-19, possibly driving their observed precautionary and cape diem behaviors during the two points of time. Heterogeneity analysis shows that specific households would dramatically change their saving behavior. These observations might be useful for policymakers who concern the economic recovery after this pandemic disaster.Originality/valueUnderstanding how the Covid-19 pandemic would affect household consumption vs saving decisions is important for the economic recovery after this disaster comes to an end. The analyses presented in this research could be useful for policymakers who concern appropriate policies aiming to boost consumption and economic activities after Covid.
Disaster conversations: intersecting perspectives on cross-cultural disaster research
Authors: Goodall Susie , Khalid Zainab , Del Pinto Monia 
Published: October 2021

PurposeThis paper aims to demonstrate the importance of conversation among disaster studies researchers who may be positioned at times and to varying degrees as both insiders and outsiders in relation to the contexts in which they work. Three key questions are explored: how we identify with and relate to people in our study areas, who we do research for and what this means for knowledge creation and research practice.Design/methodology/approachPrompted by the Power Prestige and Forgotten Values manifesto (2019), the authors conversed with one another by email and video call, asking questions that triggered reflection. The emerging themes informed the key questions and the structure of the paper. The authors write with three individual voices to highlight the element of dialogue and our different experiences.FindingsSharing in depth with other researchers from different cultural and disciplinary backgrounds created space to both listen and find a voice. Emerging themes were positionality, how knowledge is used and implications for research practice. Researchers are part of a living system with the potential to serve, exploit or damage. Knowledge is generated at multiple scales, and we can act as a bridge between people and policymakers, using networks.Practical implicationsThe authors remain open and unbiased to “new” local/contextual knowledge, adopting the attitude of a learner. Knowledge creation should focus on pragmatic outcomes such as informing emergency planning.Originality/valueA novel dialogical approach is used to demonstrate the value of conversation among researchers from different backgrounds that enables them to question and challenge each other in a supportive environment. This leads to deeper understanding of our role as cross-cultural researchers and reveals unifying questions and implications for research practice.
Communitarian norms and employee performance management in Africa
Authors: Natukunda Loice 
Published: October 2021

PurposeThe paper aims to critically evaluate the day-to-day processes of employee performance management and control (EPMC) in an African-based organization and sheds light on formal and informal management controls, social relations and worker responses.Design/methodology/approachThe paper draws on research undertaken within an Ugandan-based agricultural research organization. A case study approach was used to facilitate an understanding of everyday organizational practices and context. The paper uses ethnographic research and grounded theory, with methods including interviews and observation of work practices.FindingsThe findings provide a nuanced understanding of how performance management and control plays out in practice and show that the unquestioning imposition of Western practices that ignore traditional norms is unlikely to result in desired outcomes.Research limitations/implicationsSince the paper took on a cross-sectional study, a longitudinal study might reveal whether and how the values of managers and employees in Africa-based organizations change over time.Practical implicationsThe study's findings indicate the need for a more critical examination of EPMC that takes account of employee attitudes, behaviors and social relations at the intersection of both the formal and informal organization.Originality/valueAlthough cultural and institutional approaches have been used to evaluate human resource management (HRM) practices in Africa, organizational behavior approaches to performance and control at the micro-level had been underexplored.
Components of psychosocial health
Authors: Husain Waqar 
Published: October 2021

Purpose“Psychosocial health” is a new term to comprehend the already established factors involved in mental health and psychological well-being. The term has not been specifically defined and explained within the framework of psychology.Design/methodology/approachThe study proposed and validated a new model of psychosocial health. Principal component analysis, exploratory factor analysis and confirmatory factor analysis were conducted by involving a total of 4,086 participants.FindingsPsychosocial health was interpreted as the “sexual, emotional, social, environmental, cognitive, religious, moral and spiritual satisfaction” of a person. The proposed model of psychosocial health was statistically validated. The additional findings revealed significantly higher levels of psychosocial health in women and significant inverse correlations between psychosocial health and age.Originality/valueThe current paper provided a comprehensive picture of psychosocial health from a psychological perspective and presented a statistically reliable tool for measuring psychosocial health.
Improving service brand personality with augmented reality marketing
Authors: Plotkina Daria , Dinsmore John , Racat Margot 
Published: October 2021

PurposeAugmented reality (AR) apps offer a great opportunity for brands to provide better service to customers by creating augmented customer service. However, not every AR app is equally effective in improving customer experience. Investigation of underlying processes and brand-related outcomes of AR marketing remains scarce and it is unclear how different types of AR apps influence brand perceptions, such as brand personality. This paper aims to fill in this knowledge gap and provide practical insights on how different AR apps can improve service brand personality.Design/methodology/approachUsing an experimental plan, the authors investigate how attitudes towards AR apps contribute to customer perceptions of brand personality (i.e. excitement, sincerity, competence and sophistication) according to two different variables, namely, the location of the AR app (location-specific vs non-location-specific) and its orientation (augmenting the product, brand or store experience). The authors also examine the effect of expected customer experience with the AR app (i.e. playfulness and pleasure) and customer technological innovativeness and shopping orientation as predictors of attitudes towards the AR app.FindingsThe findings show that non-location-specific and product-oriented AR apps (i.e. virtual try-on apps) receive more positive evaluations and lead consumers to perceive the brand as more exciting, sincere, competent and sophisticated. Moreover, the playfulness and pleasure experienced with the AR app determine consumers’ attitudes towards the app. Additionally, AR apps improve brand personality perceptions amongst more innovative and adventure-focussed shoppers.Originality/valueThe authors show that brand announcements on high-technology, customer-oriented service offerings are an effective branding tool. Thus, AR apps perceived as pleasant and playful can signal and improve brand personality.
Transportation connectivity strategies and regional tourism economy - empirical analysis of 153 cities in China
Authors: Chen Juan , Li Mingwei , Xie Chen 
Published: October 2021

Purpose
A transportation connectivity strategy is a crucial part of an adaptive, congruent and sustainable tourism transportation system and is of concern to countries focusing on growing their tourism economy. This study aims to gain a better understanding of the relationship between transportation connectivity and the tourism economy through a configuration analysis.

Design/methodology/approach
This study uses fuzzy-set qualitative comparative analysis on a sample of 153 cities in China to provide an understanding of the impacts of transportation connectivity strategies, with the co-effecting factors of socio-economic status, tourism resource endowment and hospitality capacity, on the development of regional tourism economies.

Findings
There are multiple paths that lead to regional tourism economic development (a high level of tourist arrivals or a high level of tourism revenue). High-speed rail can play a supportive role, while air travel or traditional rail remains central to the tourism economy. Socio-economic status (i.e. city size and city gross domestic product) and hospitality capacity are identified as crucial influencers for the development of the tourism economy.

Research limitations/implications
This study confirms the validity of deploying configuration analysis (based on the equifinality theory) to establish the relationship between transportation and the tourism economy. The finding of more than one configuration led to a new consensus on how multiple factors influence the tourism economy.

Practical implications
Suggestions on transportation connectivity strategies for different regions are provided.

Originality/value
This study demonstrates the need to place greater emphasis on configurations that lead to tourism economy development instead of the effect of a single transportation mode.
CEO's age and acquisition behaviors of REITs
Authors: Zhang Fan , Ooi Joseph T. L. 
Published: October 2021

AbstractThis paper examines how the investment activities of REITs are affected by the age of their CEOs. Tracking the property acquisition activities of 150 REIT CEOs between 1974 and 2017, we find robust evidence of younger CEOs engaging more frequently and spending more monies on property acquisitions. Our results are consistent with younger CEOs being motivated to acquire aggressively to signal their ability to the market. However, due to reputation and career concerns, younger CEOs tend to hedge their acquisition decisions by preferring local assets and following the herd mentality. Older CEOs may engage less frequently in property acquisitions, but this is not attributed to them slowing down. On the contrary, older CEOs appear to be more confident to venture into new and out‐of‐state markets and to engage in out‐of‐wave acquisitions.
Potential usefulness of otoscopy in the evaluation of hanging deaths: A report of two cases
Authors: Wankhede Ashesh Gunwantrao 
Published: October 2021

AbstractThe significance of examination of the tympanic membrane (TM) has been previously reported in cases of strangulation, traumatic asphyxia, and drowning. We report otoscopic findings in two victims of suicidal hanging, including hemotympanum, bleeding from superficial vessels of the TM, perforation of the TM, and gross bulging of the pars‐tensa with a bluish hue. These two cases also show petechial hemorrhages in the TM, which is a previously reported finding in cases of hanging. Postmortem otoscopic examination of victims of hanging may provide information useful in the determination of vitality of hanging.
Multi‐Scale Hydrologic Evaluation of the National Water Model Streamflow Data Assimilation
Authors: Seo Bong‐Chul , Krajewski Witold F. , Quintero Felipe 
Published: October 2021

AbstractStreamflow predictions derived from a hydrologic model are subjected to many sources of errors, including uncertainties in meteorological inputs, representation of physical processes, and model parameters. To reduce the effects of these uncertainties and thus improve the accuracy of model prediction, the United States (U.S.) National Water Model (NWM) incorporates streamflow observations in the modeling framework and updates model‐simulated values using the observed ones. This updating procedure is called streamflow data assimilation (DA). This study evaluates the prediction performance of streamflow DA realized in the NWM. We implemented the model using WRF‐Hydro® with the NWM modeling elements and assimilated 15‐min streamflow data into the model, observed during 2016–2018 at 140 U.S. Geological Survey stream gauge stations in Iowa. In its current DA scheme, known as “nudging,” the assimilation effect is propagated downstream only, which allows us to assess the performance of streamflow predictions generated at 70 downstream stations in the study domain. These 70 locations cover basins of a range of scales, thus enabling a multi‐scale hydrologic evaluation by inspecting annual total volume, peak discharge magnitude and timing, and an overall performance indicator represented by the Kling–Gupta efficiency. The evaluation results show that DA improves the prediction skill significantly, compared to open‐loop simulation, and the improvements increase with areal coverage of upstream assimilation points.
Dissecting the salt tolerance potential of cowpea genotypes based on morpho‐physiology and yield‐related attributes
Authors: Akter Mafuza , Mahmud Apple , Akter Munny , Siddiqui Md. Nurealam , Khan Md. Arifur Rahman 
Published: October 2021

AbstractHigh salinity is a critical environmental menace hampering crop growth and productivity worldwide. Therefore, dissecting the salt tolerance potentials and identifying resilient genotypes are crucial to secure sustainable crop production. In this study, we explored the salt resistance potentials of three advanced cowpea lines including one check variety exposed to different salinity levels (0, 50 and 100 mM of natural saline water) by quantifying their growth, physiology and yield‐related attributes. Our results implied that salt‐stress resulted in a significant reduction in the morphological, physiological and yield attributes at both 40 and 60 days after sowing when compared to non‐stress plants. Interestingly, we noticed that one of the latest cowpea genotypes (BU‐C‐Acc‐3) sustained better performances in terms of growth, physiology and yield‐related characters at both 50 and 100 mM salt treatments, while other genotypes exhibited varying levels of salt responses. Further, a multivariate analysis showcased that genotype ‘BU‐C‐Acc‐3’ acquired a combination of physiological and yield contributing responses that ultimately induced a higher level of resistance and grain yield. Collectively, our study offers some contrasting genotypes which could be incorporated in current cowpea breeding programmes to improve grain yield and salt tolerance using conventional as well as molecular breeding tools.
A leader in need is a leader indeed? The influence of leaders' stress mindset on their perception of employee well‐being and their intended leadership behavior
Authors: Kaluza Antonia J. , Junker Nina M. , Schuh Sebastian C. , Raesch Pauline , von Rooy Nathalie K. , van Dick Rolf 
Published: October 2021

AbstractThe ability to respond appropriately to employees' work‐related well‐being requires leaders to pay attention to their employees' well‐being in the first place. We propose that leaders' stress mindset, that is, the belief that stress is enhancing versus debilitating, may bias their perception of employees' well‐being. We further propose that this judgment then influences leaders' intention to engage in or refrain from health‐oriented leadership behavior, to express higher performance expectations, or to promote their employees. We expect this process to be stronger if leaders strongly identify with their team, increasing their perceived similarity with their employees. In three experiments (N1 = 198, N2 = 292, N3 = 250), we tested the effect of participants' stress mindset on their intention to show certain leadership behaviors, mediated by their perception of employee well‐being (emotional exhaustion, somatic symptoms, work engagement) and moderated by their team identification. Our findings largely support the association between stress mindset and the perception of well‐being. The results for the proposed mediation and the moderating function of identification were mixed. Overall, the results emphasize the critical role of leaders' stress mindset and may, thus, improve health promotion in organizations by helping leaders to adequately recognize employees' well‐being and respond appropriately.
Review article: insights into the bile acid‐gut microbiota axis in intestinal failure‐associated liver disease—redefining the treatment approach
Authors: Wang Yaoxuan , Zheng Lei , Zhou Zhiyuan , Yao Danhua , Huang Yuhua , Liu Bin , Duan Yantao , Li Yousheng 
Published: October 2021

SummaryBackgroundIntestinal failure‐associated liver disease (IFALD) increases mortality of patients with intestinal failure (IF), but lacks effective prevention or treatment approaches. Bile acids, gut microbiota and the host have close and complex interactions, which play a central role in modulating host immune and metabolic homeostasis. Increasing evidence suggests that derangement of the bile acid‐gut microbiota (BA‐GM) axis contributes to the development of IFALD.AimsTo review the BA‐GM axis in the pathogenesis and clinical applications of IFALD, and to explore future directions for effective disease management.MethodsWe conducted a literature search on bile acid and gut microbiota in IF and liver diseases.ResultsThe BA‐GM axis demonstrates a unique IF signature manifesting as an increase in primary‐to‐secondary bile acids ratio, disturbed enterohepatic circulation, blunted bile acid signalling pathways, gut microbial dysbiosis, and altered microbial metabolic outputs. Bile acids and gut microbiota shape the compositional and functional alterations of each other in IF; collaboratively, they promote immune dysfunction and metabolic aberration in the liver. Diagnostic markers and treatments targeting the BA‐GM axis showed promising potential in the management of IFALD.ConclusionsBile acids and gut microbiota play a central role in the development of IFALD and make attractive biomarkers as well as therapeutic targets. A multitarget, individualised therapy aiming at different parts of the BA‐GM axis may provide optimal clinical benefits and requires future investigation.
Surgery, cancer and mortality among patients with ulcerative colitis diagnosed 1962‐1987 and followed until 2017 in a Danish population‐based inception cohort
Authors: Burisch Johan , Lophaven Søren , Munkholm Pia , Langholz Ebbe 
Published: October 2021

SummaryBackgroundLong‐term data on the natural disease course of unselected patients with ulcerative colitis (UC) are limited.AimsTo determine the long‐term course and prognosis of UC, including patients’ risks of surgery, cancer and mortality, in a population‐based cohort followed for over 50 yearsMethodsAll incident patients with UC diagnosed between 1962 and 1987 in Copenhagen County, Denmark were included in a population‐based cohort. We extracted information about IBD‐related surgeries, cancers and mortality from patient files from 1962 to 1987, and from the Danish National Patient Registry, Cancer Registry, and Register of Causes of Death during 1988‐2017. Patients were matched with up to 50 individuals from the general population.ResultsWe followed 1161 patients for a median of 34 years (range: 0.1‐56.0). Median age at diagnosis was 33 years (range: 2‐88). The cumulative probability of colectomy 10, 20, 30, 40 and 50 years after diagnosis was 22% (95% CI: 20%‐25%), 27% (95% CI: 25%‐30%), 31% (95% CI: 28%‐34%), 34% (95% CI: 31%‐37%), and 40% (95% CI: 36%‐44%), respectively. The risk of small intestinal, colon, rectal and anal cancer was higher than among controls, as was cancer of the skin, pancreas and thyroid. All‐cause mortality was lower than controls (adjusted RR: 0.90, 95% CI: 0.82‐0.99).ConclusionIn this population‐based cohort of UC patients diagnosed between 1962 and 1987, 40% underwent colectomy within 50 years of diagnosis. Physicians need to be aware that UC patients are at increased risk of intestinal and extra‐intestinal cancers. However, UC patients’ risk of mortality is comparable to that of the background population.