bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nocardioides dongkuii sp. nov. and Nocardioides lijunqiniae sp. nov., isolated from faeces of Tibetan antelope (Pantholops hodgsonii) and leaves of dandelion (Taraxacum officinale), respectively, on the Qinghai–Tibet Plateau
Authors: Cheng Yanpeng , Jiao Yifan , Zhang Sihui , Yang Jing , Lu Shan , Jin Dong , Lai Xin-He , Pu Ji , Huang Ying , Zheng Han , Bai Yibo , Wang Suping , Xu Jianguo 
Published: November 2021

In the present study, four bacterial strains, two (S-713
T
and 406) isolated from faecal samples of Tibetan antelopes and the other two (S-531
T
and 1598) from leaves of dandelion collected on the Qinghai–Tibet Plateau of PR China, were analysed using a polyphasic approach. All four isolates were aerobic, rod-shaped, non-motile, oxidase-negative, Gram-stain-positive and catalase-positive. According to four phylogenetic trees, strain pairs S-713
T
/406 and S-531
T
/1598 form two independent branches belonging to the genus

Nocardioides

, and are closest to

Nocardioides lianchengensis

,

Nocardioides dokdonensis

,

Nocardioides salarius

,

Nocardioides marinisabuli

,

Nocardioides psychrotolerans

and

Nocardioides szechwanensis

. Although sharing MK8-(H
4
) as their major isoprenoid quinone, strains S-713
T
and S-531
T
contained C
18 : 1
ω
9
c
(24.64 and 16.34 %) and iso-C
16 : 0
(9.74 and 29.38 %), respectively, as their main fatty acids, with remarkable differences in their biochemical profiles but only slight ones in their optimal growth conditions. The chromosomes of strains S-713
T
and S-531
T
were 4 207 844 bp (G+C content, 73.0 mol%) and 4 809 817 bp (G+C content, 72.5 mol%), respectively. Collectively, the two strain pairs represent two separate novel species of the genus

Nocardioides

, for which the names
Nocardioides dongkuii
sp. nov. and
Nocardioides lijunqiniae
sp. nov. are proposed, with S-713
T
(=JCM 33698
T
=CGMCC 4.7660
T
) and S-531
T
(=JCM 33468
T
=CGMCC 4.7659
T
) as the respective type strains.
A Yeast-Based Screening System for Differential Identification of Poison Inhibitors and Catalytic Inhibitors of Human Topoisomerase I
Authors: Seddek Ahmed , Madeira Christian , Annamalai Thirunavukkarasu , Mederos Christopher , Tiwari Purushottam B , Welch Aaron Z. , Tse-Dinh Yuk-Ching 
Published: November 2021

1.ABSTRACTInhibition of human topoisomerase I (TOP1) by camptothecin and topotecan has been shown to reduce excessive transcription of PAMP (Pathogen-Associated Molecular Pattern) - induced genes in prior studies, preventing death from sepsis in animal models of bacterial and SARS-CoV-2 infections. The TOP1 catalytic activity likely resolves the topological constraints on DNA that encodes these genes to facilitate the transcription induction that leads to excess inflammation. The increased accumulation of TOP1 covalent complex (TOP1cc) following DNA cleavage is the basis for the anticancer efficacy of the TOP1 poison inhibitors developed for anticancer treatment. The potential cytotoxicity and mutagenicity of TOP1 targeting cancer drugs pose serious concerns for employing them as therapies in sepsis prevention. The aim of this study is to develop a novel yeast-based screening system that employs yeast strains expressing wild-type or a dominant lethal mutant recombinant human TOP1. This yeast-based screening system can identify human TOP1 poison inhibitors for anticancer efficacy as well as catalytic inhibitors that can inhibit TOP1 DNA binding or cleavage activity in steps prior to the formation of the TOP1cc. In addition to distinguishing between such TOP1 catalytic inhibitors and TOP1 poison inhibitors, results from this yeast-based screening system will also allow elimination of compounds that are likely to be cytotoxic based on their effect on yeast cell growth that is independent of recombinant human TOP1 overexpression.
Estimating COVID-19-induced Excess Mortality in Lombardy
Authors: Maruotti Antonello , Jona-Lasinio Giovanna , Divino Fabio , Lovison Gianfranco , Ciccozzi Massimo , Farcomeni Alessio 
Published: November 2021

AbstractWe compare the expected all-cause mortality with the observed one for different age classes during the pandemic in Lombardy, which was the epicenter of the epidemic in Italy and still is the region most affected by the pandemic. A generalized linear mixed model is introduced to model weekly mortality from 2011 to 2019, taking into account seasonal patterns and year-specific trends. Based on the 2019 year-specific conditional best linear unbiased predictions, a significant excess of mortality is estimated in 2020, leading to approximately 35000 more deaths than expected, mainly arising during the first wave. In 2021, instead, the excess mortality is not significantly different from zero, for the 85+ and 15-64 age classes, and significant reductions with respect to the 2020 estimated excess mortality are estimated for other age classes.
Real-time tuning of PID controller based on optimization algorithms for a quadrotor
Authors: Can Muharrem Selim , Ercan Hamdi 
Published: November 2021

Purpose
This study aims to develop a quadrotor with a robust control system against weight variations. A Proportional-Integral-Derivative (PID) controller based on Particle Swarm Optimization and Differential Evaluation to tune the parameters of PID has been implemented with real-time simulations of the quadrotor.

Design/methodology/approach
The optimization algorithms are combined with the PID control mechanism of the quadrotor to increase the performance of the trajectory tracking for a quadrotor. The dynamical model of the quadrotor is derived by using Newton-Euler equations.

Findings
In this study, the most efficient control parameters of the quadrotor are selected using evolutionary optimization algorithms in real-time simulations. The control parameters of PID directly affect the controller’s performance that position error and stability improved by tuning the parameters. Therefore, the optimization algorithms can be used to improve the trajectory tracking performance of the quadrotor.

Practical implications
The online optimization result showed that evolutionary algorithms improve the performance of the trajectory tracking of the quadrotor.

Originality/value
This study states the design of an optimized controller compared with manually tuned controller methods. Fitness functions are defined as a custom fitness function (overshoot, rise-time, settling-time and steady-state error), mean-square-error, root-mean-square-error and sum-square-error. In addition, all the simulations are performed based on a realistic simulation environment. Furthermore, the optimization process of the parameters is implemented in real-time that the proposed controller searches better parameters with real-time simulations and finds the optimal parameter online.
Innovation capability and SME performance in times of economic crisis: does government support moderate?
Authors: Otache Innocent , Usang Obal Usang Edet 
Published: November 2021

PurposeDrawing on the dynamic capabilities theory, the purpose of this study is to empirically explore the moderating role of government support (GS) in the relationship between innovation capability (IC) and small and medium-sized enterprise (SME) performance in times of economic crisis.Design/methodology/approachThe study adopted a descriptive research design and collected data from 234 SMEs drawn from the six geopolitical zones of Nigeria using a self-reported questionnaire. PLS-SEM was performed to test the hypotheses.FindingsThe results showed that IC was positively associated with SME performance. Further analysis indicated that GS had a strong positive impact on SME performance and positively moderated the relationship between IC and SME performance.Originality/valueThere is a paucity of studies that specifically explore the moderating role of GS in the relationship between IC and SME performance. This study contributes to the literature on SMEs by demonstrating the moderating effect of GS on the relationship between IC and SME performance in times of economic crisis. The study offers valuable insights into the vital role played by IC and GS in times of economic crisis.
Backfires on firms' intangible assets of the casino industry in Macau and Las Vegas: investigating advertising expenditure
Authors: Huang Li , Liu Matthew Tingchi 
Published: November 2021

PurposeThis study quantifies the casino-industry-specific intangible assets and brand equity models from a different perspective (relative to Interbrand approach, or EquiTrend approach) to investigate the relationship between advertising expenditure and firms' intangible assets in the casino industry.Design/methodology/approachThis study collected the casino's data from the financial reports during the period of 2007–2018. The proposed model incorporates a brand structure moderator, and the peculiar characteristics (e.g. ΔS, HHI) of the casino industry based on previous research. We constructed three models for dependent variables using Tobin's Q−1. Model (1, 2, 3) as the primary regressions to firms' intangible assets (and thus serving as tests of hypotheses), as depicted in the diagrams of the firm's brand equity in different scenarios.FindingsThe results suggest that: (1) advertising expenditure has an adverse effect on firms' intangible assets; (2) the coefficients associated with brand structure dummy variables are both positive and significant; and the adverse effect is stronger for firms with house-of-brand's (HOB) and brand of house (BH) structure than for those with mixed branding structure (BH-HOB hybrid); (3) global brands have higher brand equity than local brands, with higher variance over time.Originality/valueThis study gives new evidence of the negative effect of advertising on the casino industry, which primarily reports the adverse effect of advertising in a sinful industry. Meanwhile, the proposed FBBE models can be an efficient tool to monitor a firm's annual brand equity performance with respect to their major competitors in the market.
What drives the healthcare sector's economic impact? Evidence from European countries
Authors: Jagric Timotej , Grbenic Stefan Otto , Jagric Vita 
Published: November 2021

PurposeWith high public debts and suffering economies after the COVID-19 pandemic, governments will look for ways to promote recovery. Literature substantially reports on the favorable macroeconomic impact of the healthcare sector.Design/methodology/approachThe authors use data on 19 European countries. Over 30 variables are analyzed to find factors that foster or suppress the economic impact of the healthcare sector. The economic impact is thereby expressed through five types of total multipliers, acting as dependent variables. The authors estimate multiple econometric models.FindingsThe results indicate factors that intensify or reduce the economic impact of the healthcare sector as they cause the value of one or more economic multipliers to augment or to diminish. Positive effects are expected from the growth of public funds' share in total healthcare expenditure leading to a higher output, income and value-added multipliers. The import multiplier diminishes when expenditure on healthcare as percent of GDP rises. On the other hand, rising expenditure on pharmaceuticals in the share of healthcare expenditure lowers the output multiplier. Rising GDP per capita and higher healthcare systems' technical efficiency cause the employment multiplier to lower.Originality/valuePolicymakers can strengthen the economic impact of the healthcare sector on the national economy. This could be achieved by stimulating factors, being identified in our study. Strengthening the economic impact of the healthcare sector is especially welcomed when fostering economic recovery is needed.
Reporting on COVID-19 – or not? Annual report disclosure of the pandemic as a subsequent event
Authors: Donatella Pierre , Haraldsson Mattias , Tagesson Torbjörn 
Published: November 2021

PurposeThis paper focuses on the extent to which Swedish municipalities identified and communicated risks due to the COVID-19 outbreak early on. The purpose of this paper is to explore to what extent the situational factors of the COVID-19 pandemic influenced the likelihood of municipalities disclosing COVID-19 information as a subsequent event in the annual reports of 2019.Design/methodology/approachLogistic regression models were used to estimate COVID-19 disclosure as a subsequent event. Data were handpicked from annual reports, audit reports and meeting minutes, or were retrieved from publicly available sources.FindingsRegression results indicate that municipalities issuing their annual report in a later stage of the pandemic, in regions with a higher number of confirmed COVID-19 cases, were more likely to disclose COVID-19 information as a subsequent event. However, the municipal factors used to capture the risk of a severe impact of the COVID-19 outbreak were not of major importance. In line with previous research, this study shows that political and institutional factors have explanatory power in predicting and explaining accounting disclosure choices.Originality/valueThis paper contributes to research on accounting disclosures in urgent crises and on the specific topic of subsequent events in the public sector. Few studies address subsequent events in a corporate setting and, to the best of the authors’ knowledge, none do so in the context of the public sector. This paper also offers insight into how explanatory factors, previously tested under normal conditions and circumstances, influence disclosure choices in an early stage of a health crisis characterized by uncertainty regarding both occurrence and consequences.
Does ethical leadership and psychological capital promote knowledge creation? An empirical study of research organizations
Authors: Goswami Anil Kumar , Agrawal Rakesh Kumar 
Published: November 2021

Purpose
This study aims to empirically examine the relationship of ethical leadership and psychological capital with knowledge creation. It also investigates the effect of psychological capital as a mediator in the relationship between ethical leadership and knowledge creation.

Design/methodology/approach
This study is based on quantitative research methodology. The data was gathered using a survey questionnaire from 286 members of public-sector research organizations (PSROs) in India. Structural equation modelling (SEM) was used for hypotheses testing.

Findings
The findings of this study show that ethical leadership and psychological capital have a positive influence on knowledge creation. Further, psychological capital mediated the relationship between ethical leadership and knowledge creation.

Research limitations/implications
This study is a quantitative cross-sectional study. However, future researchers may use qualitative research methodology and longitudinal data collection to supplement this study.

Practical implications
This study provides new understanding into the creation of knowledge by emphasizing on the critical role played by ethical leadership and psychological capital and, thus, makes significant theoretical contribution. It emphasizes that managers should not only be ethical but also use interventions to strengthen psychological capital of employees to strengthen knowledge creation.

Originality/value
To the best of authors’ knowledge, this is the first study to examine the underlying mechanism of psychological capital in explaining the links of ethical leadership with knowledge creation.
A bird's eye view of farm size and biodiversity: The ecological legacy of the iron curtain
Authors: Noack Frederik , Larsen Ashley , Kamp Johannes , Levers Christian 
Published: November 2021

AbstractAgriculture is a major threat to global biodiversity. A common claim is that large‐scale agro‐industrial farming is mainly responsible for the biodiversity decline, while smaller family farms are more wildlife friendly. Here we leverage a natural experiment along the former inner German border to estimate the causal impact of farm size on biodiversity. We combine land cover data with bird diversity data to establish the mechanisms through which farm size affects bird diversity. Our main results show that the increase in farm size at the former inner German border reduces bird diversity by 15%. The results suggest further that the decline is the result of land cover simplification rather than land use intensification.
Can you teach me not to be angry? Relations between temperament and the emotion regulation strategy distraction in 2‐year‐olds
Authors: Schoppmann Johanna , Schneider Silvia , Seehagen Sabine 
Published: November 2021

AbstractLittle is known about toddlers’ acquisition of specific emotion regulation (ER) strategies, and how early ER is shaped by temperament. This study investigated if 24‐month‐old German toddlers, predominantly from families with high levels of parental education (N = 96, n = 49 male), learned the ER strategy distraction through observational learning, and its interaction with temperament. Increased use of distraction correlated with reduced negative affect. Use of distraction increased through observational learning. Highly active toddlers tended to use active playing activities to distract themselves in a frustrating situation, whereas toddlers with a less active temperament used calmer activities. Toddlers’ learning to apply distraction through observational learning was independent of a match between their own temperament and the model's actions.
Long‐term outcomes of aminolevulinic acid photodynamic therapy for treatment of recalcitrant laryngeal premalignant lesions
Authors: Santeerapharp Alena , Song Sungjin A. , Woo Peak , Franco Ramon A. 
Published: November 2021

AbstractObjectiveTo assess long‐term outcomes of ALA‐PDT in treating recalcitrant laryngeal leukoplakia.Study designRetrospective Case‐Control.MethodsWe reviewed all laryngeal leukoplakia patients treated with ALA‐PDT compared with angiolytic laser treatment alone (585 nm PDL or 532 nm KTP laser) from 2000 to 2019. Patients with laryngeal cancer (or a history of laryngeal cancer), leukoplakia previously treated with radiation and no pathologic report were excluded. Patient demographics, procedure details and outcomes were examined including histopathologic diagnosis, procedures performed, ALA usage, recurrence of leukoplakia and the development of cancer.ResultsWe identified 132 patients with laryngeal leukoplakia: 42 were treated with ALA‐PDT and 90 were treated with an angiolytic laser alone (Laser group). The proportion of cases of high‐grade dysplasia was 57.1% in the ALA‐PDT group compared to 32.2% in the Laser group. In high‐grade dysplasia cases, there was a statistically significant better recurrence‐free survival (RFS) at 12 months and 60 months in those who underwent ALA‐PDT 71.4% and 7.1% vs Laser 25% and 0% (p = .01). However, for overall groups, there was no difference in RFS (p = .25). Voice outcomes (patient subjective report) improved or were stable in 75% of subjects with no serious side effects reported.ConclusionALA‐PDT for recalcitrant and high‐grade dysplasia is highly effective with improved recurrence‐free survival compared to laser alone. ALA‐PDT may be an appropriate therapy in patients who have failed prior angiolytic laser alone.
Allergic contact dermatitis from (“hypoallergenic”) adhesives containing D‐limonene
Authors: Dendooven Ella , Foubert Kenn , Naessens Tania , Pieters Luc , Lambert Julien , Goossens An , Aerts Olivier 
Published: November 2021

AbstractBackgroundBesides being a potential component of (some species of) colophonium, D‐limonene is also used as a tackifier in the production of adhesives. Hydroperoxides of limonene are well‐known skin sensitizers.ObjectivesTo show that D‐limonene may be present in colophonium‐containing but also colophonium‐free (“hypoallergenic”) adhesives, and that patients suffering from allergic contact dermatitis (ACD) from both types of adhesives might display positive patch test reactions to limonene hydroperoxides in this regard.MethodsFive patients with suspected ACD from adhesives were patch tested to the baseline series (containing limonene hydroperoxides 0.3 and 0.2% pet.), additional series and, if available, to the culprit adhesives. The adhesives labelled as containing colophonium (n = 3) or free from it (n = 2) were analysed with gas chromatography ‐ mass spectrometry (GC‐MS) for the presence of D‐limonene.ResultsAll five patients sensitised to adhesives had (strong) positive patch test reactions to limonene hydroperoxides. The presence of D‐limonene, and/or related components, could be demonstrated in all three colophonium‐containing and, surprisingly, also in two colophonium‐free (“hypoallergenic”) tapes.ConclusionsD‐limonene may be present in both regular and “hypoallergenic” adhesives, with limonene hydroperoxides potentially contributing to ACD from such medical devices. The use of fragrance chemicals in adhesives deserves further research.
Effects of nurse‐led home‐based telephone support or home visits on cognitive function
Authors: Mao Nanqi , Xue Fangyuan , Cai Wanyu , Li Jiahong 
Published: November 2021

AbstractPatients who have undergone carotid revascularization surgery have a high risk of postoperative cognitive decline, and home‐based care is the major form of postoperative management. Here, we aimed to compare the nurse‐led home‐based telephone support (NLHBTS) and home visits as additional postoperative care for patients who have undergone carotid revascularization surgery. The study recruited 172 patients, and 131 patients were randomly assigned to receive combined telephone support and home visits (intervention group) or home visits alone (control group) during the study period of 12 weeks. At baseline, 1 month, and 3 months, cognitive function was assessed using the Trail Making Test, Processing Speed Index, Boston Naming Test, Working Memory Index, Controlled Oral Word Association Test, and Hopkins Verbal Test. Sixty‐five patients in the intervention group and 66 in the control group completed the 1‐month treatment, and 49 in the intervention group and 48 in the control group completed the 3‐month treatment. The intervention group showed significant improvement in four of the six cognitive tests after the 3‐month treatment, whereas the control group only showed significant improvement in the Controlled Oral Word Association Test. Compared to the control group, significantly higher scores were achieved by the intervention group at 3 months in the Trail Making Tests (113 ± 23 vs. 128 ± 18, p = 0.001), Processing Speed Index (115 ± 15 vs. 108 ± 14, p = 0.020), Controlled Oral Word Association Test (51 ± 11 vs. 45 ± 9, p = 0.004), and Hopkins Verbal Learning Test (9.0 ± 1.6 vs. 8.3 ± 1.8, p = 0.046). NLHBTS, in combination with home visits, could facilitate the improvement of cognitive function in patients with carotid artery stenosis after surgery.