bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into the Multilevel Structural Characterization and Adsorption Mechanism of Sinogastromyzon szechuanensis Sucker on the Rough Surface
Authors: Cong Qian , Xu Jin , Fan Jiaxiang , Chen Tingkun , Ru Shaofeng 
Published: September 2021

The present study investigates the adsorption performance and adsorption mechanism of Sinogastromyzon szechuanensis on different rough surfaces. The different positions of the sucker surface of Sinogastromyzon szechuanensis were observed by adopting the stereomicroscope and SEM. The observed results showed that the sucker of Sinogastromyzonszechuanensis had a multilevel structure of villi and groove. The anterior and posterior of Sinogastromyzonszechuanensis had different microscopic morphologies. The surface roughness of the adsorption substrate ranged from 7 μm to 188 μm. Adsorption strength of Sinogastromyzonszechuanensis and the conventional sucker on different rough surfaces were measured by a purposely designed device. The results showed that the back of Sinogastromyzonszechuanensis mainly provided the adsorption strength. The adsorption strength of the conventional sucker gradually decreased with surface roughness increasing, but the adsorption strength of Sinogastromyzon szechuanensis had not changed significantly. Based on the experimental results, the adsorption mechanism of Sinogastromyzonszechuanensis on the surface with different roughness was analyzed by the spectral function. The Sinogastromyzonszechuanensis sucker with a multilevel structure worked well on the rough surface, which led to Sinogastromyzonszechuanensis with a good sealing on the rough surface. The present work could help to develop a new type of sucker with effective adsorption performance on a rough surface to meet the needs of the engineering field.
GRAPHIC DESIGN IN FUTURE LABOR EDUCATION TEACHER’S COMPUTER CULTURE FORMATION
Authors: Tytarenko V. , Cherniavsky T. 
Published: September 2021

The article considers the issues of modern graphic design of Ukraine from the perspectives of national orientation. The development of graphic design in Ukraine and the influence of regional factors on the peculiarities of its formation are highlighted. The absence of a general model of Ukrainian graphic design and the possibility of its development prospects is proved. The experience of introduction of graphic design in the process of future teachers’ computer culture formation is described. The role of graphic design tools in the formation of future labor education teacher’s computer culture is clarified. The basic principles of graphic design and its features as a tool of future labor education teacher’s professional activity are outlined. The peculiarities of computer culture formation using graphic design are substantiated. The means of graphic design, which form the future labor education teacher’s computer culture, are analyzed.
The concept of graphic activity is considered as a component of design and emphasis is placed on the importance of such activity while making design. The current stage of future labor education teacher’s computer culture formation using graphic design is characterized. The role of computer training and knowledge of the relevant software packages is considered. The place of computer competence within future labor education teacher’s general professional competence is determined. The means of graphic design which are used in the process of future labor education teacher’s computer competence formation are allocated, their features are revealed, their efficiency and advantages of application at various stages of training are defined. Basic knowledge, skills, and abilities in the field of future labor education teacher’s computer culture formation are systematized.
Discovery of Novel Proteomic Biomarkers for the Prediction of Kidney Recovery from Dialysis-Dependent AKI Patients
Authors: Daniels Jaclyn R. , Ma Jennie Z. , Cao Zhijun , Beger Richard D. , Sun Jinchun , Schnackenberg Laura , Pence Lisa , Choudhury Devasmita , Palevsky Paul M. , Portilla Didier , Yu Li-Rong 
Published: September 2021

Key Points

High throughput proteomics detected serum protein levels in patients with AKI-D who recovered kidney function.Novel predictive biomarkers of kidney recovery from patients with AKI-D were discovered.Potential biologic pathways associated with kidney remodeling, repair, and regeneration were suggested.

Background
AKI requiring dialysis (AKI-D) is associated with prolonged hospitalization, mortality, and progressive CKD among survivors. Previous studies have examined only select urine or serum biomarkers for predicting kidney recovery from AKI.

Methods
Serum samples collected on day 8 of randomized RRT from 72 patients enrolled in the Veteran's Affairs/National Institutes of Health Acute Renal Failure Trial Network study were analyzed by the SOMAscan proteomic platform to profile 1305 proteins in each sample. Of these patients, 38 recovered kidney function and dialysis was discontinued, whereas another 34 patients remained on dialysis by day 28.

Results
Differential serum levels of 119 proteins, with 53 higher and 66 lower, were detected in samples from patients who discontinued dialysis, compared with patients who remained on dialysis by day 28. Patients were classified into tertiles on the basis of SOMAscan protein measurements for the 25 proteins most differentially expressed. The association of serum levels of each protein with kidney recovery was further evaluated using logistic regression analysis. Higher serum levels of CXCL11, CXCL2/CXCL3, CD86, Wnt-7a, BTK, c-Myc, TIMP-3, CCL5, ghrelin, PDGF-C, survivin, CA2, IL-9, EGF, and neuregulin-1, and lower levels of soluble CXCL16, IL1RL1, stanniocalcin-1, IL-6, and FGF23 when classified in tertiles were significantly associated with better kidney recovery. This significant association persisted for each of these proteins after adjusting for potential confounding risk factors including age, sex, cardiovascular SOFA score, congestive heart failure, diabetes, modality of intensive dialysis treatment, cause of AKI, baseline serum creatinine, day 8 urine volume, and estimated 60-day mortality risk.

Conclusions
These results suggest concerted changes between survival-related proteins and immune-regulatory chemokines in regulating angiogenesis, endothelial and epithelial remodeling, and kidney cell regeneration, illustrating potential mechanisms of kidney recovery. Thus, this study identifies potential novel predictive biomarkers of kidney recovery in patients with AKI-D.
Elucidation of electron and hole transfer at high temperature in Ag-doped Na and Al phosphate glasses
Authors: Kawamoto Hiroki , Kawamura Ichiro , Komiya Hajime , Koshimizu Masanori , Fujimoto Yutaka , Asai Keisuke 
Published: September 2021

Abstract
Ag-doped phosphate glasses are used in radiophotoluminescence (RPL) dosimeters. Ag0, Ag2+ and Ag2
+ act as luminescence centers of RPL in the glass, whereas they disappear when annealed. To understand the reason for the RPL disappearance phenomenon, thermoluminescence (TL) glow curves, RPL temperature dependence electron spin resonance spectra were measured for the self-made Na and Al phosphate glass (Na–Al) and Ag-doped Na–Al made by Chiyoda Technol (FD-7). It is shown conclusively that in FD-7, electrons trapped at Ag2
+ recombine with a part of holes trapped at hole trapping sites other than PO4
3− tetrahedra at 350–400 K, while electrons trapped at Ag2
+ recombine with holes trapped at Ag2+ at 400–500 K. Subsequently, holes trapped at Ag2+ recombine with electrons trapped at electron trapping sites other than Ag2
+ to induce TL at 520–650 K.
PRACTICE OF PROPER HANDWASHING AND ITS ASSOCIATED FACTORS AMONG STAFF IN A MALAYSIAN UNIVERSITY
Authors: Oo San San , Ibrahim Mohd Salami , Thwe Aung Myat Moe , Mohd Yusop Yuzana , Hassan Azmi , Naing Nyi Nyi , Mohd Amin Rahmah , Abd Aziz Aniza , Nik Mahdi Nik Nor Ronaidi 
Published: September 2021

In higher education setting throughout the world, the practise of handwashing among staff is essential, particularly in the period of COVID-19 pandemic. Despite the overwhelming evidence on the effectiveness of proper handwashing, the knowledge, attitude and practice of handwashing among the staff of higher education have not been well investigated. Consequently, a cross-sectional study among staff in a university in Malaysia was conducted to identify the prevalence of proper handwashing and its associated factors. The data was collected using questionnaires in Google form from 18th June to 21st June 2020. Statistical analyses involved simple and multiple logistic regression with backward likelihood ratio method. Out of 349 participants, 31.8% (95% CI: 26.9,36.7) had proper handwashing practice. The results of the multivariable analysis revealed that the total knowledge scores (OR: 1.04, 95% CI: 1.001, 1.071) and the total attitude scores (OR: 1.23, 95% CI: 1.152, 1.321) were found to be significantly associated with proper handwashing practice among staff. Our study suggests that having the right knowledge and favourable attitudes are crucial towards achieving the proper handwashing practise. Additional supports for promoting a conducive ecosystem may also likely be needed to sustain a long-term practice of proper handwashing.
Search for Long-duration Gravitational-wave Signals Associated with Magnetar Giant Flares
Authors: Macquet A. , Bizouard M. A. , Burns E. , Christensen N. , Coughlin M. , Wadiasingh Z. , Younes G. 
Published: September 2021

Abstract
Magnetar giant flares are rare and highly energetic phenomena observed in the transient sky whose emission mechanisms are still not fully understood. Depending on the nature of the excited modes of the magnetar, they are also expected to emit gravitational waves (GWs), which may bring unique information about the dynamics of the excitation. A few magnetar giant flares have been proposed to be associated with short gamma-ray bursts. In this paper we use a new gravitational-wave search algorithm to revisit the possible emission of GWs from four magnetar giant flares within 5 Mpc. While no gravitational-wave signals were observed, we discuss the future prospects of detecting signals with more sensitive gravitational-wave detectors. In particular, we show that galactic magnetar giant flares that emit at least 1% of their electromagnetic energy as GWs could be detected during the planned observing run of the LIGO and Virgo detectors at design sensitivity, with even better prospects for third-generation detectors.
Numerical Models of Externally Irradiated Herbig–Haro Objects
Authors: Estrella-Trujillo D. , Velázquez P. F. , Raga A. C. , Esquivel A. 
Published: September 2021

Abstract
We use 3D radiation–hydrodynamic simulations to study the effects of an external photoionization source on the structure of a Herbig–Haro (HH) jet launched from a young stellar object. Different ionizing photon rates are considered as well as a time-dependent ejection velocity and density. From our numerical results, synthetic Hα emission maps are computed in order to study how the external ionizing source affects the observed morphology of the jet and counterjet. We find that, as expected, the outflow has jet/counterjet and side-to-side asymmetries (with brighter Hα emission toward the external photoionizing source). We find that, for a variable ejection velocity, jet morphologies similar to different observed externally irradiated jets can be straightforwardly obtained. Models of jets with a variable ejection density (and constant outflow velocity) produce morphologies that are not seen in observed HH jets and are, therefore, not justified by the presently available observations.
Isolation, identification and virulence determinants of Streptococcus agalactiae from bovine subclinical mastitis in Egypt
Authors: Abd El-Razik Khaled Abd EL-Hamid , Arafa Amany A , Fouad Ehab A , Younes Abdelgayed M , Almuzaini Abdulaziz M , Abdou Amr M 
Published: September 2021

Introduction: This study aimed to investigate the prevalence of contagious mastitis caused by Streptococcus agalctiae (S. agalactiae) in cattle from households and small-scale dairy farms in Egypt. Molecular characterization of S.agalactiae isolates was described including the genetic determinants of virulence to assess the genetic variation in isolated strains of S. agalactiae.
Methodology: Three hundred and sixty milk samples were collected from 90 apparently healthy dairy cows randomly selected from household and small-scale dairy farms were examined by Somatic Cell Count (SCC) as an indicator for subclinical mastitis. S.agalactiae isolates were bacteriologically and molecularly identified followed by identification of virulence genes using PCR.
Results: A total of 172 milk samples (47.77%) were positive with SCC > 200×103/ml. Bacteriological examination of the positive SCC milk samples revealed that 28 (16.28%) of the isolates were S.agalactiae. Molecular examination using PCR confirmed only 22 isolates of S. agalactiae (12.8%). Moreover, we used the pattern of virulence genes to address the genetic variation of S. agalactiae strains isolated from cases of contagious mastitis in cattle in Egypt. Virulence genes hylB, cylE, iagA, and bac were determined in 100%, 68.2%, 13.6% and 100% of isolates respectively.
Conclusions: The use of molecular methods for the identification of the causative agent in mastitis confirmed that, in Egypt, Streptococcus agalactiae is considered as one of the predominant infectious agents among contagious mastitis causing pathogens. The pattern of virulence genes presented the genetic diversity of highly virulent S. agalactiae strains isolated from cases of contagious mastitis in cattle in Egypt.
Frequency of CCR5-Δ32, CCR2-64I and SDF1-3'A alleles in HIV-infected and uninfected patients in Istanbul, Turkey
Authors: Köksal Muammer Osman , Akgül Baki , Beka Hayati , Çiftçi Sevgi , Keskin Fahriye , Eraksoy Haluk , Ağaçfidan Ali 
Published: September 2021

Introduction: Co-receptors involved in cell entry of the human immunodeficiency virus (HIV) and mutations in genes encoding their ligands may play a role in the susceptibility to infection and resistance to the progression of the infection. The best studied mutations that can exist in these genes are the CCR5-Δ32, CCR2-64I and SDF1-3'A mutations. The frequency of these mutations vary from continent to continent and even from region to region. However, there is limited information on their distribution throughout the Turkish population. Istanbul is the city with the highest number of documented HIV-infected patients in Turkey, which can be attributed to the population size. The aim of this study was to determine the distribution of three AIDS-related gene variants among HIV-infected and uninfected population in Istanbul, Turkey and to estimate the contribution of these variants to susceptibility or resistance to HIV.
Methodology: A total of 242 healthy individuals and 200 HIV-positive patients were included in the study. CCR5 polymorphisms were genotyped by polymerase chain reaction. CCR2 and SDF1 polymorphisms were genotyped using PCR restriction fragment length polymorphism (PCR-RFLP).
Results: The allelic frequencies for CCR5-Δ32, CCR2-64I and SDF1-3’A were 4.07%, 19.8% and 28.7%, respectively. No individual was found to carry the homozygous CCR5-Δ32 mutation in either cohort. No polymorphism was found to be significantly elevated in the HIV-infected cohort compared to the healthy group.
Conclusions: The distribution of CCR5-Δ32, CCR2-64I, and SDF1-3'A variants does not differ between HIV-infected and uninfected patients. CCR2-64I and SDF1-3'A frequencies are relatively high where as the frequency of CCR5-Δ32 is low.
The Relationship between Pregnancy-related Anxiety and Maternal-fetal Attachment among Primigravida
Authors: Anjarwati Anjarwati , Koni Suryaningsih Endang 
Published: September 2021

BACKGROUND: Many studies support the hypothesis that pregnancy-related anxiety (PRA) is strongly linked to postpartum depression, preterm births, low birth weight, fetal growth restriction, pregnancy complications, and negative infant outcomes. PRA has also been associated with mother-fetal bond during pregnancy that a special relationship between the mother and infant and growth beyond before the infant is born. Although extensive studies on PRA and maternal-fetal attachment (MFA) have been carried out, little attention on these issues is done in the Indonesian context. AIM: To fill such a gap, the present study aimed to investigate the relationship between maternal PRA and MFA. METHODS: Expectant mothers who visit their antenatal care in the primary health community services at Yogyakarta participated in this study. They were recruited using a purposive sampling technique based on the criteria: (a) The 1st time pregnancy, (b) in the late stage of pregnancy, (c) have no complication, (d) mother at any age range, and (e) mother at any education level. G-power 3.1.9.2 with effect size 0.15 has used to determine the number of samples, 84 people. Statistical analysis Pearson correlation has been applied and calculates the t relationship between two variables. General linier model analysis conducted the contribution of demographic variables to PRA and MFA. RESULTS: There is a significant relationship between maternal anxiety during pregnancy and MFA (p < 0.001) and a significant correlation between PRA and maternal age. However, there were no correlation between MFA and demographic variables. IMPLICATION FOR PRACTICE: Findings study provides the crucial information as the new approach to enhance the quality of care of mother’s and infant’s health during pregnancy as well as to promote maternal mental health.
Ado ou addict : il faut choisir !
Authors: Haza Marion , Bernaud Joan 
Published: September 2021

Dans cet article, à partir du cas clinique de Mark, 15 ans, adolescent aux prises du pubertaire et de stupéfiants, nous proposons une réflexion autour de la difficulté à appréhender les conduites addictives extrêmes à l’adolescence et à offrir une possibilité de soin réellement adapté. L’article montre comment Mark est dans une problématique d’agirs typiquement adolescente, impliquant des consommations massives, des violences envers lui-même et des conduites suicidaires. Il indique également les difficultés de continuité de soin à apporter à ces adolescents ne rentrant pas dans les cases prédéfinies de la psychiatrie. L’objectif de ce texte est d’illustrer avec Mark cette réalité bien repérée de cloisonnement entre pédopsychiatrie et addictologie, nuisant aux prises en charge et nécessitant de lier processus pubertaire et enjeux des addictions. Il nous semble que l’analyse de la clinique des addictions en termes de sensorialité et symbolisation (à savoir selon une appréhension du monde au plus près des sensations et du corporel) ouvre la voie vers de nouveaux regards à porter sur ces actes symptomatologiques, afin d’apprécier une prise en charge englobant tant les enjeux du pubertaire que de la psychiatrie des conduites addictives.
The Effectiveness and Safety of Dextenza 0.4 mg for the Treatment of Postoperative Inflammation and Pain in Patients After Photorefractive Keratectomy: The RESTORE Trial
Authors: Ibach Mitchel J. , Shafer Brian M. , Wallin Doug D. , Puls-Boever Keeley R. , Thompson Vance M. , Berdahl John P. 
Published: September 2021

PURPOSE:
To determine patient preference and treatment outcomes with an intracanalicular dexamethasone 0.4 mg insert compared to a standard steroid drop regimen in the contralateral eye following bilateral photorefractive keratectomy (PRK).

METHODS:
In this randomized, prospective, self-controlled, open-label interventional study, one eye received the dexamethasone insert and the second eye received prednisolone acetate 1% taper following bilateral PRK surgery. Postoperative evaluations were performed on day 3, day 4, month 1, and month 3. Phone call surveys were performed on week 2. The Comparison of Ophthalmic Medications for Tolerability questionnaire was used to determine patient preference between postoperative regimens and postoperative pain. Corneal endpoints included time to epithelialization, presence of corneal haze, sodium fluorescein staining, and modified Standardized Patient Evaluation of Eye Dryness (SPEED) scores. Both corrected distance visual acuity (CDVA) and uncorrected distance visual acuity (UDVA) were assessed.

RESULTS:
Twenty patients participated in the study. At month 3, 70% of patients preferred the dexamethasone insert, 20% preferred prednisolone acetate, and 10% expressed no preference. Patient surveys did not show a difference in postoperative pain between the study group and control group. No statistical difference was shown in time to epithelialization, 90-day CDVA or UDVA, postoperative corneal haze, corneal staining, or modified SPEED scores.

CONCLUSIONS:
In patients undergoing PRK, there was preference toward a dexamethasone insert in place of topical prednisolone acetate for the postoperative steroid treatment. There were no statistically or clinically significant differences between the two cohorts in regard to healing time or visual outcomes.

[
J Refract Surg
. 2021;37(9):590–594.]
Development and validation of a predictive model for feeding intolerance in intensive care unit patients with sepsis
Authors: Hu Kunlin , Deng Xin lei , Han Lin , Xiang Shulin , Xiong Bin , Pinhu Liao 
Published: September 2021

Background:
Feeding intolerance in patients with sepsis is associated with a lower enteral nutrition (EN) intake and worse clinical outcomes. The aim of this study was to develop and validate a predictive model for enteral feeding intolerance in the intensive care unit patients with sepsis.

Methods:
In this dual-center, retrospective, case-control study, a total of 195 intensive care unit patients with sepsis were enrolled from June 2018 to June 2020. Data of 124 patients for 27 clinical indicators from one hospital were used to train the model, and data from 71 patients from another hospital were used to assess the external predictive performance. The predictive models included logistic regression, naive Bayesian, random forest, gradient boosting tree, and deep learning (multilayer artificial neural network) models.

Results:
Eighty-six (44.1%) patients were diagnosed with enteral feeding intolerance. The deep learning model achieved the best performance, with areas under the receiver operating characteristic curve of 0.82 (95% confidence interval = 0.74–0.90) and 0.79 (95% confidence interval = 0.68–0.89) in the training and external sets, respectively. The deep learning model showed good calibration; based on the decision curve analysis, the model's clinical benefit was considered useful. Lower respiratory tract infection was the most important contributing factor, followed by peptide EN and shock.

Conclusions:
The new prediction model based on deep learning can effectively predict enteral feeding intolerance in intensive care unit patients with sepsis. Simple clinical information such as infection site, nutrient type, and septic shock can be useful in stratifying a septic patient's risk of EN intolerance.
Classical and Quantum Mechanical Models of Many-Particle Systems
Authors: Carlen Eric A. , Fellner Klemens , Gallagher Isabelle , Jabin Pierre Emmanuel 
Published: September 2021

The collective behaviour of many-particle systems is a common denominator in the challenges of a highly diverse range of applications: from classical problems in Physics (gas dynamics e.g. Boltzmann’s equation, plasma dynamics e.g. various Vlasov equations, semiconductors, quantum mechanics) to current models in biology (kinetic models for collective interaction e.g. swarming, evolution of trait-structured species) to rising topics in social sciences (opinion formation, crowding phenomena) and economics (wealth distribution, mean-field games).
Key mathematical questions concern the analysis (global-in-time wellposedness, regularity), rigorous scaling resp. macroscospic limits (model reduction from many-particle models to mean-field/mesoscopic descriptions to macroscopic evolutions), efficient and asymptotic preserving numerical methods and qualitative results (e.g. large-time equilibration).