bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Stokes system with solution-dependent subdifferential boundary conditions
Authors: Zhao Jing , Migórski Stanisław , Dudek Sylwia 
Published: November 2021

AbstractWe study the Stokes problem for the incompressible fluid with mixed nonlinear boundary conditions of subdifferential type. The latter involve a unilateral boundary condition, the Navier slip condition, a nonmonotone version of the nonlinear Navier–Fujita slip condition, and the threshold slip and leak condition of frictional type. The weak form of the problem leads to a new class of variational–hemivariational inequalities on convex sets for the velocity field. Solution existence and the weak compactness of the solution set to the inequality problem are established based on the Schauder fixed point theorem.
Allometric equations for estimating on-farm fuel production of Gliricidia sepium (Gliricidia) shrubs and Cajanus cajan (pigeon pea) plants in semi-arid Tanzania
Authors: Hafner J. M. , Steinke J. , Uckert G. , Sieber S. , Kimaro A. A. 
Published: November 2021

Abstract
Background
Fuelwood is considered to be the primary source of cooking energy in Tanzania and, due to ongoing deforestation, access to fuelwood is becoming more cumbersome. On-farm agroforestry systems can reduce dependency on off-farm fuel; however, the output of on-farm produced fuel is typically uncertain as production potentials are often not known. In this paper, we have developed allometric equations to model the above-ground woody biomass (AGWB) production from intercropped Gliricidia sepium (Jacq.) Kunth ex Walp (Gliricidia) shrubs and Cajanus cajan (L.) Millsp. (pigeon pea) plants.

Methods
We used a destructive sampling approach, for measuring the dendrometric characteristics, such as the root collar diameter at a 20 cm stem height (RCD20) and the stem height to estimate the AGWB production. The models are based on 112 Gliricidia and 80 pigeon pea observations from annually pruned plants. Seven allometric equations were fitted to derive the best-fit models for the AGWB production.

Results
We found that using a natural log-transformed linear model with RCD20 as a single predictor variable provides the highest explanatory value to estimate the AGWB production (Gliricidia: R2 = 95.7%, pigeon pea: R2 = 91.4%) while meeting Ordinary Least Square (OLS) estimator requirements. Adding stem height as an additional variable to predict the AGWB production does not improve model accuracy enough to justify the extra work for including it.

Conclusions
While on-farm pigeon pea plants produced a stable amount of woody biomass per annum, annual fuelwood production from Gliricidia shrubs increased over the years. Compared to the annual fuelwood consumption data from the literature, our results show that on-farm produced fuelwood can substantially offset the demand for off-farm fuel, potentially resulting in household fuelwood autarky.
The determinants of survival among adults with cystic fibrosis—a cohort study
Authors: Durda-Masny Magdalena , Goździk-Spychalska Joanna , John Aleksandra , Czaiński Wojciech , Stróżewska Weronika , Pawłowska Natalia , Wlizło Jolanta , Batura-Gabryel Halina , Szwed Anita 
Published: November 2021

Abstract
Background
Cystic fibrosis (CF) is one of the most common autosomal recessive diseases. Factors contributing to disease exacerbations and survival rate of CF patients are type of mutation in the CFTR gene, poor nutritional status, lung failure, and infection development by Pseudomonas aeruginosa. The study aimed to evaluate the relationship between the severity of mutation, nutritional status, lung function, and Pseudomonas aeruginosa prevalence and survival rate in adult patients with cystic fibrosis.

Methods
A study of 124 (68 ♀ and 56 ♂) adults with CF aged 18–51 years were evaluated for (a) type of mutation in the CFTR gene, (b) nutritional status (BMI), (c) lung function (FEV1%), and (d) Pseudomonas aeruginosa prevalence. For statistical calculations, Kaplan-Meier analysis of survival, chi-squared test for multiple samples, and logistic regression were used.

Results
The type of mutation (χ2 = 12.73, df = 3, p = 0.005), FEV1% (χ2 = 15.20, df = 2, p = 0.0005), Pseudomonas aeruginosa prevalence (χ2 = 11.48, df = 3, p = 0.009), and BMI (χ2 = 31.08, df = 4, p < 0.000) significantly differentiated the probability of survival of patients with CF. The shortest life expectancy was observed in patients with a severe type of mutation on both alleles, FEV1% < 40, subjects in whom Pseudomonas culture was extensively drug-resistant or pandrug-resistant, and patients whose BMI was lower than 18.5 kg/m2. The period from 30 to 40 years of age was the most critical in CF adults’ lifespan. The risk of adults with CF death doubled with Pseudomonas aeruginosa prevalence (OR = 2.06, 95% CI 1.29; 2.28) and eightfold when the bacteria acquired antibiotic resistance (OR = 8.11, 95% CI 1.67; 38.15).

Conclusions
All factors included in the study were significantly related to the survival rate of patients with cystic fibrosis.
The power of feeling seen: perspectives of individuals with eating disorders on receiving validation
Authors: Geller Josie , Fernandes A. , Srikameswaran S. , Pullmer R. , Marshall S. 
Published: November 2021

Abstract
Background
A common complaint of individuals suffering from mental health conditions is feeling invalidated or misunderstood by care providers. This is notable, given that non-collaborative care has been linked to poor engagement, low motivation and treatment non-adherence. This study examined how receiving validation from care providers is experienced by individuals who have an eating disorder (ED) and the impact of receiving validation on the recovery journey.

Methods
Eighteen individuals who had an eating disorder for an average duration of 19.1 years (two identifying as male, 16 identifying as female), participated in semi-structured interviews on barriers and facilitators to self-compassion. Seven were fully recovered, and 11 were currently participating in recovery-focused residential treatment. Thematic analysis focused on the meaning and impact of receiving validation to participants.

Results
Five care provider actions were identified: (i) making time and space for me, (ii) offering a compassionate perspective, (iii) understanding and recognizing my treatment needs, (iv) showing me I can do this, and (v) walking the runway. These were associated with four key experiences (feeling trust, cared for, empowered, and inspired), that participants described as supportive of their recovery.

Conclusions
This research provides insight into patient perspectives of validation and strategies care providers can use, such as compassionate reframing of difficult life experiences, matching interventions to patient readiness, and modeling vulnerability.
Techno-economic analysis of a new downstream process for the production of astaxanthin from the microalgae Haematococcus pluvialis
Authors: Bauer Andreas , Minceva Mirjana 
Published: November 2021

AbstractThe biotechnological production of the carotenoid astaxanthin is done with the microalgae Haematococcus pluvialis (H. pluvialis). Under nutrient deficiency and light stress, H. pluvialis accumulates astaxanthin intracellularly and forms a resistant cyst cell wall that impedes direct astaxanthin extraction. Therefore, a complex downstream process is required, including centrifugation, mechanical cell wall disruption, drying, and supercritical extraction of astaxanthin with CO2. In this work, an alternative downstream process based on the direct extraction of astaxanthin from the algal broth into ethyl acetate using a centrifugal partition extractor (CPE) was developed. A mechanical cell wall disruption or germination of the cysts was carried out to make astaxanthin accessible to the solvent. Zoospores containing astaxanthin are released when growth conditions are applied to cyst cells, from which astaxanthin can directly be extracted into ethyl acetate. Energy-intensive unit operations such as spray-drying and extraction with supercritical CO2 can be replaced by directly extracting astaxanthin into ethyl acetate. Extraction yields of 85% were reached, and 3.5 g of oleoresin could be extracted from 7.85 g homogenised H. pluvialis biomass using a CPE unit with 244 mL column volume. A techno-economic analysis was done for a hypothetical H. pluvialis production facility with an annual biomass output of 8910 kg. Four downstream scenarios were examined, comparing the novel process of astaxanthin extraction from homogenised cyst cells and germinated zoospores via CPE extraction with the conventional industrial process using in-house or supercritical CO2 extraction via an external service provider. After 10 years of operation, the highest net present value (NPV) was determined for the CPE extraction from germinated zoospores.
Is an individually tailored programme of intense leg resistance and dynamic exercise acceptable to adults with an acute lateral patellar dislocation? A feasibility study
Authors: Forde Colin , Haddad Mark , Hirani Shashivadan P. , Keene David J. 
Published: November 2021

Abstract
Background
Lateral patellar dislocations mainly affect active teenagers and young adults. To help people recover, non-surgical exercise-based treatment is often recommended but the optimal exercise-based treatment is unknown. Currently, treatment outcomes after this injury are variable. Common problems include recurrent dislocation, reduced activity levels, and later surgery. A programme of intense leg resistance exercises, and dynamic exercises related to participants’ activity-related goals, has rationale, but has not been previously reported. In line with the Medical Research Council guidance, this study aimed to assess the acceptability of a novel evidence-based exercise programme for adults after acute lateral patellar dislocation and the feasibility of future research evaluating this treatment.

Methods
A single-group prospective study was conducted at the John Radcliffe Hospital, Oxford, UK. Participants were 16 years or older with an acute first-time or recurrent lateral patellar dislocation. Participants received up to six face-to-face, one-to-one, physiotherapy sessions, over a maximum of 3 months, and performed intensive home exercises independently at least three times per week. Strategies to increase exercise adherence were used. Primary objectives were to determine the number of eligible patients, the recruitment rate (proportion of eligible patients that provided written informed consent), participant adherence to scheduled physiotherapy sessions and self-reported adherence to prescribed exercise, and intervention acceptability to participants measured by attrition and a study-specific questionnaire. Data were analysed using descriptive statistics.

Results
Fifteen of 22 (68%) patients with a lateral patellar dislocation were eligible. All eligible (100%) were recruited. Two of 15 (13%) participants provided no outcome data, 2/15 (13%) provided partial outcome data, and 11/15 (73%) provided all outcome data. Questionnaire responses demonstrated high intervention acceptability to participants. Participants attended 56/66 (85%) physiotherapy sessions and 10/11 (91%) participants reported they ‘always’ or ‘often’ completed the prescribed exercise. One participant redislocated their patella; another experienced knee pain or swelling lasting more than one week after home exercise on three occasions.

Conclusion
The intervention appeared acceptable to adults after acute lateral patellar dislocation, and a future randomised pilot trial is feasible. This future pilot trial should estimate attrition with increased precision over a longer duration and assess participants’ willingness to be randomised to different treatments across multiple centres.

Trial registration
ClinicalTrials.govNCT03798483, registered on January 10, 2019
Quality of life, burden of treatment, safety, and avoidance of future events (QBSAfe) protocol: a pilot study testing an intervention to shift the paradigm of diabetes care
Authors: Clark Jennifer E. , Boehmer Kasey R. , Breslin Maggie , Haider Shanzay , Pasciak Weronika , Gravholt Derek , Sanchez Brianna B. , Hartasanchez Sandra A. , El Kawkgi Omar M. , Montori Victor , Lipska Kasia J. 
Published: November 2021

Abstract
Background
Diabetes care has been traditionally focused on targeting certain levels of glycemic control. This narrow emphasis may impose burdens on patients, including high treatment costs, illness-related work, or side effects from medications, while leaving other patient needs and goals under-addressed. The authors aim to shift the paradigm of care for people with diabetes, to focus on quality of life, burden of treatment, safety, and avoidance of future events: the QBSAfe domains.

Methods
We describe a single-arm pilot study to assess the feasibility and acceptability of using the QBSAfe agenda setting kit (ASK) during routine clinical visits. The set of 14 conversation aid cards was co-developed with patients, family caregivers, and clinicians. The ASK will be used in the context of a clinic visit, which will be recorded by members of the study team to identify patterns of clinician-patient conversations. Feasibility will be measured by the number of participants recruited, time to goal accrual, and completeness of data collection; acceptability will be assessed using post-visit surveys of patients and clinicians. A subgroup of patients will be invited to participate in post-visit qualitative semi-structured interviews for additional feedback. This study will be conducted across three medical centers in the Midwest and East Coast of the USA.

Discussion
Current healthcare infrastructure and associated demands and pressures on clinicians make changes in care difficult. However, this intervention has the potential to shift conversations during clinical encounters so they can address and directly respond to patient needs, symptoms, and capacity. As part of the QBSAfe ASK, the authors are also actively collaborating with a variety of stakeholders to create tools to help clinicians respond more effectively to patient concerns as they are raised during the clinical encounters. Additional insights about the use of the QBSAfe approach in the virtual space will be gathered during the process of our study due to restrictions imposed upon face to face visit during the COVID-19 pandemic.

Trial registration
ClinicalTrials.gov, NCT04514523. Registered 17 August 2020—retrospectively registered.
Safety and feasibility study of using polyphosphate (PolyP) in alveolar cleft repair: a pilot study
Authors: Alkaabi Salem A. , Kalla Diandra Sabrina Natsir , Alsabri Ghamdan A. , Fauzi Abul , Jansen Nova , Tajrin Andi , Nurrahma Rifaat , Müller Werner , Schröder Heinz C. , Xiaohong Wang , Forouzanfar Tymour , Helder Marco N. , Ruslin Muhammad 
Published: November 2021

Abstract
Background
Bone grafting is an important surgical procedure to reconstruct alveolar bone defects in patients with cleft lip and palate. Polyphosphate (PolyP) is a physiological polymer present in the blood, primarily in platelets. PolyP plays a role as a phosphate source in bone calcium phosphate deposition. Moreover, the cleavage of high-energy bonds to release phosphates provides local energy necessary for regenerative processes. In this study, polyP is complexed with calcium to form Calcium polyP microparticles (Ca-polyP MPs), which were shown to have osteoinductive properties in preclinical studies. The aim of this study was to evaluate the feasibility, safety, and osteoinductivity of Ca-polyP MPs, alone or in combination with BCP, in a first-in-human clinical trial.

Methods
This single-blinded, parallel, prospective clinical pilot study enrolled eight adolescent patients (mean age 18.1: range 13–34 years) with residual alveolar bone cleft. Randomization in two groups (four receiving Ca-polyP MPs only, four a combination of Ca-polyP MPs and biphasic calcium phosphate (BCP)) was performed. Patient follow-up was 6 months. Outcome parameters included safety parameters and close monitoring of possible adverse effects using radiographic imaging, regular blood tests, and physical examinations. Osteoinductivity evaluation using histomorphometric analysis of biopsies was not possible due to COVID restrictions.

Results
Due to surgical and feasibility reasons, eventually, only 2 patients received Ca-polyP MPs, and the others the combination graft. All patients were assessed up to day 90. Four out of eight were able to continue with the final assessment day (day 180). Three out of eight were unable to reach the hospital due to COVID-19 restrictions. One patient decided not to continue with the study.
None of the patients showed any allergic reactions or any remarkable local or systematic side effects. Radiographically, patients receiving Ca-polyP MPs only were scored grade IV Bergland scale, while patients who got the BCP/Ca-polyP MPs combination had scores ranging from I to III.

Conclusions
Our results indicate that Ca-polyP MPs and the BCP/Ca-polyP MPs combination appear to be safe graft materials; however, in the current setting, Ca-polyP MPs alone may not be a sufficiently stable defect-filling scaffold to be used in alveolar cleft repair.

Trial registration
Indonesian Trial Registry under number INA-EW74C1N by the ethical committee of Faculty of Medicine, Hasanuddin University, Makassar, Indonesia with code number 1063/UN4.6.4.5.31/PP36/2019.
Posterior and postero-lateral incidental durotomy during lumbar spine surgery: primary repair versus augmented primary repair
Authors: Makia Mansour A. , Alawamry Ahmed , Elsharkawy Ahmad M. 
Published: November 2021

Abstract
Background
Incidental durotomy (ID) during lumbar spine surgery is a frequent complication of lumbar spine surgical procedures. Many surgical techniques were described in literature for repair of durotomy, however it is a matter of debate if one technique is a gold standard method of repair. Our study described two groups with posterior and postero-lateral ID that occurred during lumbar spine surgery: group A with 34 cases with a mean age of 49.85 years repaired by primary water tight closure using prolene or silk sutures, and group B with 34 cases with a mean age of 47.18 years treated with augmented primary repair (sutures augmented with a graft from lumbar fascia and tissue sealant "Fibrin glue"). Patients were evaluated for risk factors for durotomy, post-operative clinical outcome, and need for revision surgery.

Results
Eleven cases of group A and nine cases of group B had previous spine surgery. The dural tear was < 2 cm in 41.7% of group A and 83.3% of group B. Better outcome was achieved in 32 patients of group A and 30 patients of group B. Among our study cases 2 patients from group A and 4 patients from group B needed revision surgery due to CSF leak which failed to stop with conservative management and percutaneous blood patch.

Conclusions
Dural closure technique after ID does not seem to influence revision surgery rates due to cerebrospinal fluid (CSF) leakage and its complications. Durotomies that were immediately recognized and treated did not lead to any significant consequences.
The impact of education through nurse-led telephone follow-up (telenursing) on the quality of life of COVID-19 patients
Authors: Raesi Rasoul , Shaye Zahra Abbasi , Saghari Sam , Sheikh Beig Goharrizi Mohammad Ali , Raei Mehdi , Hushmandi Kiavash 
Published: November 2021

Abstracts
Background
The widespread prevalence of COVID-19 has disrupted the social life, physical function, and daily activities of patients, leading to reduced quality of their lives. Because of the nature of this disease and its comprehensive impact on patients’ lives, a follow-up based on the conditions of these patients is necessary. This study was conducted to determine the impact of nurse education and telephone follow-up (telenursing) on the quality of life of COVID-19 patients.

Methods
This quasi-experimental study included 120 COVID-19 patients discharged from 22nd-Bahman Hospital in Khaf city and was conducted over 6 months from July 20, 2020, to December 20, 2020. The participants were selected by convenience sampling method and were assigned into two matching groups. The training was delivered through telenursing based on the quality of life criteria for 1 month in the intervention group. The controls did not receive any intervention. Both groups completed the 36-item SF health survey before and 1 month after the intervention.

Results
The two groups were not significantly different regarding the quality of life mean scores at baseline (p = 0.61). However, after the intervention, the mean and standard deviation of the total life quality score was significantly different between the control and intervention groups (63.62 ± 3.93 versus 72.62 ± 3.51, p <0.001).

Conclusions
Telenursing improves the life quality of COVID-19 patients. Through appropriate policies, health managers may put on the agenda the implementation of telenursing for COVID-19 patients.
Centering social-technical relations in studying platform urbanism: intersectionality for just futures in European cities
Authors: Webster Natasha A. , Zhang Qian 
Published: November 2021

AbstractPlatform-based services are rapidly transforming urban work, lives and spaces around the world. The rise of platforms dependent on largely expendable labour relations, with significant migrant involvement, must be seen as connected, and as replicating larger social processes rather than merely technological changes. This perspective paper urgently calls for an intersectional perspective to better understand social-technical relations crossing the digital-urban interface of platform urbanism in contemporary European cities. Critics of platforms and gig work, to date, have mainly focused on algorithms-based social control, degraded working conditions, problematic employment relations and precariousness of gig work. The ongoing Covid-19 pandemic has both disrupted and amplified these issues, intensifying the vulnerability of gig workers. For example, in Sweden, migrant groups and gig workers were separately identified as being hardest hit by Covid, but with little attention to the interconnectivity between these categories, nor to how these groups are co-positioned vis-a-vis larger socio-economic inequalities. Thus, we argue for a deeper understanding of the social processes underlying platforms and for active investigation of how inequalities are being produced and/or maintained in/by these processes. Urban planners, designers and policy makers will need to actively address the hybrid (digital and physical) urban spaces produced in platform urbanism in order to prevent spatial and economic inequalities. We argue for a stronger recognition of interrelated and overlapping social categories such as gender and migrant status as central to the construction of mutually constitutive systems of oppression and discrimination produced in and through the platform urbanism.