bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is the 3D exoscope better than the surgical microscope in parotid surgery: a prospective, randomized single-center study
Authors: Bartkowiak Ewelina , Łuczewski Łukasz , Chou Jadzia Tin-Tsen , Wierzbicka Małgorzata 
Published: May 2021

Abstract
Background
High-definition, three-dimensional (3D) exoscopes are being used to perform a growing number of head and neck surgeries. However, the use of the 3D exoscope in parotid gland surgery has not been previously described. Our initial experience with the VITOM 3D exoscope in the surgical treatment of parotid gland tumors is detailed here.

Methods
We made a prospective study of patients with benign parotid gland tumors indicated for surgical resection. Between January and December 2018, patients were randomly assigned to undergo surgery assisted with the VITOM 3D system (n = 31) or an operating microscope (n = 40). Visualization quality (greater auricular nerve, digastric muscle, tragal pointer), operating time, conversion rates, and surgical outcomes were compared.

Results
A total of 71 patients underwent superficial (n = 18) or total parotidectomy (n = 53). No exoscope-related complications were observed. Five patients undergoing exoscope-guided deep lobe surgery required intraoperative conversion to a microscope. No differences were observed in the subjective quality of intraoperative visualization of key anatomical structures. However, a significantly higher percentage of patients in the exoscope group developed transient facial nerve paralysis (n = 9; 29% vs. n = 4, 10%).

Conclusions
These findings suggest that the VITOM 3D is a valid visualization tool for parotid gland surgery, comparable to the operating microscope but with higher resolution 3D visualization, an increased degree of freedom of movement, and better ergonomics. However, the high rate of transient nerve palsy, possibly related to decreased depth perception and the brief learning curve, merits further investigation.
Effects of the short-stitch technique for midline abdominal closure: short-term results from the randomised-controlled ESTOIH trial
Authors: Albertsmeier M. , Hofmann A. , Baumann P. , Riedl S. , Reisensohn C. , Kewer J. L. , Hoelderle J. , Shamiyeh A. , Klugsberger B. , Maier T. D. , Schumacher G. , Köckerling F. , Pession U. , Weniger M. , Fortelny R. H. 
Published: May 2021

Abstract
Purpose
The short-stitch technique for midline laparotomy closure has been shown to reduce hernia rates, but long stitches remain the standard of care and the effect of the short-stitch technique on short-term results is not well known. The aim of this study was to compare the two techniques, using an ultra-long-term absorbable elastic suture material.

Methods
Following elective midline laparotomy, 425 patients in 9 centres were randomised to receive wound closure using the short-stitch (USP 2-0 single thread, n = 215) or long-stitch (USP 1 double loop, n = 210) technique with a poly-4-hydroxybutyrate-based suture material (Monomax®). Here, we report short-term surgical outcomes.

Results
At 30 (+10) days postoperatively, 3 (1.40%) of 215 patients in the short-stitch group and 10 (4.76%) of 210 patients in the long-stitch group had developed burst abdomen [OR 0.2830 (0.0768–1.0433), p = 0.0513]. Ruptured suture, seroma and hematoma and other wound healing disorders occurred in small numbers without differences between groups. In a planned Cox proportional hazard model for burst abdomen, the short-stitch group had a significantly lower risk [HR 0.1783 (0.0379–0.6617), p = 0.0115].

Conclusions
Although this trial revealed no significant difference in short-term results between the short-stitch and long-stitch techniques for closure of midline laparotomy, a trend towards a lower rate of burst abdomen in the short-stitch group suggests a possible advantage of the short-stitch technique.

Trial registry
NCT01965249, registered October 18, 2013.
Spatial and temporal dynamics of suspended particles and E. coli in a complex surface-water and karst groundwater system as a basis for an adapted water protection scheme, northern Vietnam
Authors: Richter Dominik , Goeppert Nadine , Zindler Björn , Goldscheider Nico 
Published: May 2021

AbstractKarst aquifers in subtropical regions are characterized by high variability of water availability and quality due to changes associated with rainy and dry seasons. An additional challenge for water management is the combination of surface-water and karst groundwater systems since high spatiotemporal dynamics cause high variability of water quality. In these cases, adapted protection strategies are required. In this study, a protection approach for the catchment of a river-water diversion point in a rural area in northern Vietnam is developed. The variability of water quality was evaluated by rainy and dry season synoptic surveys of suspended particles and microbial contamination at 49 sites and time series at three sets of paired sites under constant hydraulic conditions. The anthropogenic land-use activities in the catchment were mapped to identify potential contamination sources and to highlight the challenging combination of surface-water and karst groundwater management. The analyzed data indicate differences in water quality between the dry and rainy seasons and a higher influence on water quality from land use than from hydrologic conditions. Furthermore, the results suggest a high risk of contamination resulting from residential areas, agriculture, and livestock farming, and reveal the necessity of implementation of appropriate measures such as restricted farming and the hook-up of buildings to municipal sewage disposal. Finally, the data show that water quality can be improved by adjusting water withdrawals by the time of day. The applied methods can be transferred to other surface-water and karst groundwater systems in similar subtropical environments.
Decision-making, cognitive functions, impulsivity, and media multitasking expectancies in high versus low media multitaskers
Authors: Müller Silke M. , Schiebener Johannes , Brand Matthias , Liebherr Magnus 
Published: May 2021

AbstractIn several studies, individuals who reported to frequently multitask with different media displayed reduced cognitive performance, for example in fluid intelligence and executive functioning. These cognitive functions are relevant for making advantageous decisions under both objective risk (requiring reflection and strategical planning) and ambiguous risk (requiring learning from feedback). Thus, compared to low media multitaskers (LMMs), high media multitaskers (HMMs) may perform worse in both types of decision situations. The current study investigated HMMs and LMMs in a laboratory setting with the Game of Dice Task (GDT; objective risk), the Iowa Gambling Task (IGT; ambiguous risk), various tests quantifying cognitive functions (logical reasoning, working memory, information processing, general executive functions), and self-report measures of impulsivity, media multitasking expectancies, and problematic Internet use. From 182 participants, 25 HMMs and 19 LMMs were identified using the Media Multitasking Index. Results show that HMMs compared to LMMs performed weaker on the IGT but not on the GDT. Furthermore, HMMs had slightly decreased performance in tests of logical reasoning and working memory capacity. HMMs tended to increased information processing speed but this difference was not significant. Furthermore, HMMs have more positive expectancies regarding media multitasking and reported higher tendencies toward problematic Internet use. HMMs and LMMs did not differ significantly with respect to impulsivity and executive functions. The results give a first hint that HMMs may have difficulties in decision-making under ambiguous but not under objective risk. HMMs may be more prone to errors in tasks that require feedback processing. However, HMMs appear not to be impaired in aspects of long-term strategic decision-making.
An empirically sound telemedicine taxonomy – applying the CAFE methodology
Authors: Harst Lorenz , Otto Lena , Timpel Patrick , Richter Peggy , Lantzsch Hendrikje , Wollschlaeger Bastian , Winkler Katja , Schlieter Hannes 
Published: May 2021

AbstractAimBecause the field of information systems (IS) research is vast and diverse, structuring it is a necessary precondition for any further analysis of artefacts. To structure research fields, taxonomies are a useful tool. Approaches aiming to develop sound taxonomies exist, but they do not focus on empirical development. We aimed to close this gap by providing the CAFE methodology, which is based on quantitative content analysis.Subject and methodsExisting taxonomies are used to build a coding scheme, which is then validated on an IS project database. After describing the methodology, it is applied to develop a telemedicine taxonomy.ResultsThe CAFE methodology consists of four steps, including applicable methods. It helps in producing quantitative data for statistical analysis to empirically ground any newly developed taxonomy. By applying the methodology, a taxonomy for telemedicine is presented, including, e.g. application types, settings or the technology involved in telemedicine initiatives.ConclusionTaxonomies can serve in identifying both components and outcomes to analyse. As such, our empirically sound methodology for deriving those is a contribution not only to evaluation research but also to the development of future successful telemedicine or other digital applications.
A discrete-cracking numerical model for the in-plane behavior of FRCM strengthened masonry panels
Authors: Murgo Francesco Saverio , Ferretti Francesca , Mazzotti Claudio 
Published: May 2021

AbstractIn this paper, the structural behavior of masonry panels strengthened with a system made up of composite fiber grids embedded in a cementitious matrix (FRCM) is presented. The non-linear behavior of the unreinforced and reinforced panels is numerically simulated by means of a simplified micro-modelling approach. This approach concentrates all the non-linearities and failures in the joints and in potential crack surfaces within the bricks, placed vertically in the middle of each brick. The FRCM strengthening system is discretized by a continuous bi-directional fiber grid constituted by trusses embedded into a cementitious matrix. A calibrated bond-slip relationship is applied between the fibers and the mortar matrix assuming an idealized bilinear law. The typical experimental load–displacement curve for a FRCM strengthened panel shows three principal phases that correspond to different failure mechanisms: masonry cracking, mortar matrix cracking and ultimate failure of the panel. The non-linear numerical analyses show a good agreement with experimental results and the modeling approach is found to be adequate to reproduce the described experimental behavior. The results of a parametric study on both the material and the geometrical properties of the FRCM system are also presented.
Fast and quantitative compositional analysis of hybrid cellulose-based regenerated fibers using thermogravimetric analysis and chemometrics
Authors: Guizani Chamseddine , Trogen Mikaela , Zahra Hilda , Pitkänen Leena , Moriam Kaniz , Rissanen Marja , Mäkelä Mikko , Sixta Herbert , Hummel Michael 
Published: May 2021

AbstractCellulose can be dissolved with another biopolymer in a protic ionic liquid and spun into a bicomponent hybrid cellulose fiber using the Ioncell® technology. Inside the hybrid fibers, the biopolymers are mixed at the nanoscale, and the second biopolymer provides the produced hybrid fiber new functional properties that can be fine-tuned by controlling its share in the fiber. In the present work, we present a fast and quantitative thermoanalytical method for the compositional analysis of man-made hybrid cellulose fibers by using thermogravimetric analysis (TGA) in combination with chemometrics. First, we incorporated 0–46 wt.% of lignin or chitosan in the hybrid fibers. Then, we analyzed their thermal decomposition behavior in a TGA device following a simple, one-hour thermal treatment protocol. With an analogy to spectroscopy, we show that the derivative thermogram can be used as a predictor in a multivariate regression model for determining the share of lignin or chitosan in the cellulose hybrid fibers. The method generated cross validation errors in the range 1.5–2.1 wt.% for lignin and chitosan. In addition, we discuss how the multivariate regression outperforms more common modeling methods such as those based on thermogram deconvolution or on linear superposition of reference thermograms. Moreover, we highlight the versatility of this thermoanalytical method—which could be applied to a wide range of composite materials, provided that their components can be thermally resolved—and illustrate it with an additional example on the measurement of polyester content in cellulose and polyester fiber blends. The method could predict the polyester content in the cellulose-polyester fiber blends with a cross validation error of 1.94 wt.% in the range of 0–100 wt.%. Finally, we give a list of recommendations on good experimental and modeling practices for the readers who want to extend the application of this thermoanalytical method to other composite materials.
Focus variation technology as a tool for tissue surface characterization
Authors: Reitbauer Jürgen , Harrer Franz , Eckhart Rene , Bauer Wolfgang 
Published: May 2021

Abstract
The surface of tissue paper is relatively complex compared to other paper grades and consists of several overlapping structures like protruding fibres, crepe and fabric-based patterns at different spatial frequencies. The knowledge of tissue surface characteristics is crucial when it comes to improvement with respect to surface softness and the perceptual handfeel of tissue products. In this work we used the optical based, non-contact measurement principle of focus variation for surface characterization of dry-creped, textured and through air dried (TAD) tissue. Based on the three tissue grades, a procedure which includes the characterization of the whole tissue surface throughout different scales within one setup, was developed. Surprisingly, focus variation was rarely used in tissue-related research, as it provides robust and reliable 3D surface information which can be used for further areal surface analysis. Special attention was given to the preparation and discussion of the raw data up to the final analysis including several spatial filtering steps. Enhanced surface parameters like the developed interfacial area ratio (Sdr) and the power spectral density (PSD) were used to describe the surface adequately. The surface roughness of the three tissue grades was compared, with the textured tissue showing the highest roughness in Sdr and PSD analysis. Although both methods are based on different principles, a high correlation in terms of evaluated roughness is evident. Regular structures like crepe and patterns are obtainable as peaks at the respective frequency with a certain intensity in the PSD evaluation. Apart from topography in terms of structures and roughness, the wide field of view of the focus variation measurement also allows assessment of effects related to flocculation and sheet formation. The developed procedure could also be appropriate for other fibre based materials and/or fabrics, which are similar to tissue with respect to optical properties such as for example nonwovens.

Graphic abstract
Comparison of clinical features between immune-related sclerosing cholangitis and hepatitis
Authors: Takinami Masaki , Ono Akira , Kawabata Takanori , Mamesaya Nobuaki , Kobayashi Haruki , Omori Shota , Wakuda Kazushige , Kenmotsu Hirotsugu , Naito Tateaki , Murakami Haruyasu , Endo Masahiro , Kiyohara Yoshio , Yasui Hirofumi , Niwakawa Masashi , Takahashi Toshiaki 
Published: May 2021

SummaryBackground Immune-related hepatotoxicity is often regarded as immune-related hepatitis (irHepatitis) despite including immune-related sclerosing cholangitis (irSC). This study examined the clinical differences between irSC and irHepatitis. Methods A single-center retrospective study of 530 consecutive patients who received immunotherapy between August 2014 and April 2020 was performed. IrSC and irHepatitis were respectively defined as the radiological presence and absence of bile duct dilation and wall thickness. Results Forty-one patients (7.7%) developed immune-related hepatotoxicity. A CT scan was performed on 12 patients, including 11 of 12 with ≥ grade 3 aminotransferase elevations. IrSC and irHepatitis were diagnosed in 4 (0.8%) and 8 (1.5%) patients, respectively. All the irSC patients had been treated with anti-PD-1. IrHepatitis was more common among patients receiving anti-CTLA-4 than among those receiving anti-PD-1/PD-L1 inhibitors (14%, 7/50 vs. 0.2%, 1/480, P < 0.001). A ≥ grade 2 alkaline phosphatase (ALP) elevation resulting in a cholestatic pattern was seen in all 4 irSC patients. Among the irSC patients, 3 (3/4, 75%) developed ≥ grade 3 aminotransferases elevation. The median duration from the start of immunotherapy until ≥ grade 2 liver enzymes elevation was 257 and 55.5 days in irSC and irHepatitis patients. The median times for progression from grade 2 to 3 liver enzyme elevation were 17.5 and 0 days, respectively. Conclusions IrSC and irHepatitis have different characteristics in the class of immune checkpoint inhibitor and onset pattern. Radiological examination for the diagnosis of irSC should be considered for patients with ≥ grade 2 ALP elevation resulting in a cholestatic pattern. (Registration number J2020-36, Date of registration June 3, 2020)
Modelling Stakeholder Dynamics for Supporting Group Decision and Negotiation: Theory to Practice
Authors: Eden Colin , Ackermann Fran 
Published: May 2021

AbstractGroup Decision and Negotiation methods can help identify optimal, or efficient, solutions to complex problems and so aid decision-makers. However, recommendations depend for their success, in part, on their political feasibility within, usually, complex organisational settings. A part of the complexity of effective implementation derives from understanding the responses of stakeholders to the proposed decisions. The responses of stakeholders can be complex because stakeholders respond not just to the decision but also to the responses of other stakeholders. When the recommendations are very important, and when the possible stakeholder responses are likely to be complex, then the use of some form of modelling ofstakeholder dynamicsis likely to be helpful. This paper proposes such a modelling process designed to aid the thinking of a decision-making team as they seek to ensure their decision is politically feasible. The modelling process is designed to facilitate effective negotiation in groups about the potential impact of stakeholder responses. The modelling process is illustrated through a real case.
Up-regulation of DNA2 results in cell proliferation and migration in endometriosis
Authors: Wang Xinyan , Zeng Wenjie , Xu Sheng , Nie Jingya , Huang Lu , Lai Yucheng , Yu Yan 
Published: May 2021

AbstractAccumulating evidence has suggests that women with advanced endometriosis exhibit alterations in the expression of genes in the endometrium compared to healthy controls. Furthermore, replication stress is a characteristic feature of cancer cells, which results from sustained proliferative signaling induced by either the activation of oncogenes or the loss of tumor suppressors. In the present study, we propose that DNA replication ATP-dependent helicase/nuclease 2 (DNA2) might be upregulated in endometriosis. Immunohistochemical staining results confirmed the hypothesis that DNA2 is overexpressed in the eutopic/ectopic endometrium compared to that in a control endometrium from a healthy donor. Subsequently, ectopic endometrium-derived endometrial mesenchymal stem cells (EMSCs) showed the highest level of DNA2 and checkpoint kinase 1 (CHK1), as well as the strongest proliferation and migration capabilities, followed by eutopic endometrium-derived EMSCs, and then control EMSCs. To further analyze the function of DNA2, we knocked-down DNA2 expression in KLE cells. As expected, proliferation and migration declined when cells were transfected with DNA2 small interfering RNA. Taken together, our study demonstrated the overexpression of DNA2 in human endometriosis, which might be responsible for the upregulated cell proliferation and migration. This study provides insights into the mechanisms underlying human endometriosis.
Interpretive structural modelling of inter-agency collaboration risk in public safety networks
Authors: Sienkiewicz-Małyjurek Katarzyna 
Published: May 2021

AbstractInter-agency collaboration is a well-established, yet very difficult process in public governance. Despite the fact that it is often unsuccessful, collaboration risk research is still undeveloped and the impact of this risk on the effectiveness of joint activities is still underestimated. This issue is of particular significance in public safety networks, where inter-agency collaboration processes are conducted under the conditions of the complexity and uncertainty. For this reason, the article is intended to: (1) identify factors of collaboration risk in public safety networks, (2) determine the impact of individual risk factors on inter-agency collaboration outcomes, (3) identify the relationship between risk factors of inter-agency collaboration in public safety networks, and (4) analyse the growth of this risk in public safety networks. These purposes were achieved using the Systematic Literature Review based on PRISMA Group methodology and Interpretive Structural Modelling together with MICMAC analysis. The applied research approach also has some limitations resulting from the number of experts. However, the results obtained allow us to better understand issues of inter-agency collaboration risk in public safety networks. They identify key collaboration risk factors, such as inappropriate collaboration rules and inadequate allocation of tasks and resources. In consequence, they indicate risk symptoms that are worth keeping track of in order to prevent collaboration ineffectiveness.
BAC transgenic mice to study the expression of P2X2 and P2Y1 receptors
Authors: Grohmann Marcus , Schumacher Michaela , Günther Janka , Singheiser Stefan M. , Nußbaum Tanja , Wildner Florian , Gerevich Zoltan , Jabs Ronald , Hirnet Daniela , Lohr Christian , Illes Peter , Schmalzing Günther , Franke Heike , Hausmann Ralf 
Published: May 2021

AbstractExtracellular purines are important signaling molecules involved in numerous physiological and pathological processes via the activation of P2 receptors. Information about the spatial and temporal P2 receptor (P2R) expression and its regulation remains crucial for the understanding of the role of P2Rs in health and disease. To identify cells carrying P2X2Rs in situ, we have generated BAC transgenic mice that express the P2X2R subunits as fluorescent fusion protein (P2X2-TagRFP). In addition, we generated a BAC P2Y1R TagRFP reporter mouse expressing a TagRFP reporter for the P2RY1 gene expression. We demonstrate expression of the P2X2R in a subset of DRG neurons, the brain stem, the hippocampus, as well as on Purkinje neurons of the cerebellum. However, the weak fluorescence intensity in our P2X2R-TagRFP mouse precluded tracking of living cells. Our P2Y1R reporter mice confirmed the widespread expression of the P2RY1 gene in the CNS and indicate for the first time P2RY1 gene expression in mouse Purkinje cells, which so far has only been described in rats and humans. Our P2R transgenic models have advanced the understanding of purinergic transmission, but BAC transgenic models appeared not always to be straightforward and permanent reliable. We noticed a loss of fluorescence intensity, which depended on the number of progeny generations. These problems are discussed and may help to provide more successful animal models, even if in future more versatile and adaptable nuclease-mediated genome-editing techniques will be the methods of choice.