bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of urinary glutathione S-transferase with serum creatinine in sepsis-induced acute kidney injury: A prospective and observational study
Authors: Kumari Nidhi , Parashar Samiksha , Giri Manoj , Tripathi Manoj , Kumar Virendra , Kumar Suraj 
Published: December 2024

ABSTRACT

Background:
Sepsis-induced acute kidney injury (AKI) is difficult to prevent because most patients are diagnosed after they develop it. Standard serum and urine creatinine levels are insensitive and nonspecific for detecting kidney injury in its early stages. Glutathione S-transferase (GST) has received little attention as a biomarker in AKI.

Methods:
This study included 65 adult patients with sepsis who developed oliguria within 72 h of admission. Baseline serum creatinine values were recorded at least 1 month before or after intensive care unit (ICU) admission. The clinical endpoints were defined as the occurrence of advanced AKI stages 2 or 3 according to the KDIGO classification. Serum creatinine and urinary GST levels were measured every 6 h from admission until 72 h postoliguria development. The primary objective was to assess the correlation between urinary GST and serum creatinine levels in patients with sepsis-induced AKI.

Results:
Among the 65 patients, 13 (20%) progressed to AKI Grade I, while 52 (80%) progressed to AKI Grade II or III. Both groups exhibited an increasing trend in serum creatinine and urinary GST levels up to 72 h. Significant mean differences between the two AKI groups were observed at 48 and 72 h for serum creatinine (P = 0.021 and P = 0.007, respectively) and at 18 h for urinary GST levels (P = 0.044).

Conclusion:
Urinary GST levels demonstrated an earlier elevation than serum creatinine levels in critically ill sepsis patients, underscoring their utility as a valuable tool for the early diagnosis and predicting AKI following admission to the ICU.
A Study on Quantification of the Effects of Heartfulness Meditation Intervention in Healthcare Professionals by Anchor-Based Method in Occupational Health Psychology
Authors: Sharma Deepak B. , Sharma Himanshu 
Published: December 2024

Background:
It’s more important to measure the subjective perception of change after undergoing any behavioral or psychological intervention. Global rating of change method—anchor item-based is a method by which the change can be quantified and “minimum subjective perceived effect” (MSPE) can be calculated.

Aim:
The current study was planned to quantify the effects of heartfulness meditation intervention in healthcare professionals by anchor-based method and compare the result with the pre-post-difference.

Methods and Material:
The current study was done using multimethod study design among the healthcare professionals. These were 1. Cross-sectional study design. 2. Quasi-experimental—Solomon four-nonequivalent control group study design for intervention.

Results:
Cohens’ d for perceived stress scale (PSS) in “Much less negative” category was -.96.

Conclusion:
The study highlights the use of anchor-based method to estimate the minimal subjective perceived difference, and it can also be compared with the groups pre-post-difference for academic purposes.
Prevalence and Risk Factors of Medication Errors in Enteral Tube Feeding Among ICU Patients: A Comprehensive Cross-Sectional Analysis
Authors: Asghari-Varzaneh Mansooreh , Badri Shirinsadat , Farsaei Shadi 
Published: December 2024

ABSTRACT

Objective:
Most of the patients who are admitted to the intensive care unit (ICU) are forced to feed and use nutrition and medicine through an implanted tube. When administering medication through enteral feeding tubes, it is essential to be cautious, as some drugs may not be suitable due to interactions with feeding formulas or adverse effects when crushed. Some errors during drug gavage can lead to feeding tube blockage, reduced drug effectiveness, or drug toxicity. This study aimed to assess medication errors (MEs) in ICU patients using enteral feeding tubes and identify factors that affect ME incidents.

Methods:
This descriptive and analytical study was conducted for 9 months in the special care department of hospitals affiliated with Isfahan University of Medical Sciences. It involved 257 patients in the ICU receiving oral medication through an implanted gastric tube. The study assessed the method of oral drug administration, verified the correctness of drug prescriptions, investigated errors in drug provision and administration, and monitored patients for possible side effects of these errors. Demographic information and details about the prescribing physician and relevant nurses were also recorded.

Findings:
Our findings show that not washing the tube before gavage was the most frequent error (99.6%). However, different factors, whether the patient or the nurse, did not affect them. The other most common errors included mixing drugs simultaneously (75.6%) and not cleaning the tube after administering medication (78.6%). These errors were influenced by factors such as the number of drugs received by the patient, the hospital, and specific shifts.

Conclusion:
In this study, we found that polypharmacy, the multiplicity of underlying diseases, and nurses’ gender are the most critical factors that increase the number of MEs during the gavage of drugs in patients hospitalized in ICUs.
A rare case of Kearns–Sayre syndrome in a 19-year-old North Indian male
Authors: Kaur Rajwinder , Kour Mandeep , Sandhu Ravi Kaur 
Published: December 2024

Abstract
Kearns–Sayre syndrome (KSS) is a rare neuromuscular condition characterized by a combination of chronic progressive external ophthalmoplegia (CPEO), pigmentary retinopathy, atrioventricular block, and cerebellar ataxia. We report a rare case of a 19-year-old young male of north Indian origin with KSS. He has a history of bilateral ptosis, progressive restricted ocular movements, decreased vision in both eyes, and difficulty walking. He was diagnosed with CPEO, a form of KSS, along with retinal pigmentary abnormalities. Early detection of these cases is critical for saving the patient’s life as they may lead to atrioventricular block.
Review on the etiopathogenesis, clinical features, and management of pseudo-tumor cerebri
Authors: Periyandavan Jayasri , Stephen Mary , Kasturi Nirupama , Sahi Arun 
Published: December 2024

Abstract
Pseudotumor cerebri is an idiopathic disease characterized by elevated intracranial pressure with associated symptoms and signs. Headache is often the initial presentation, and other associated findings include papilledema, vision loss, and sixth nerve palsy. Numerous risk factors have been proposed to be causative, including obesity, use of oral contraceptive pills, and vitamin A toxicity. Neuroimaging, especially magnetic resonance imaging (MRI) with venography, is crucial for diagnosing and ruling out any other organic pathology that could lead to papilledema. The cerebrospinal fluid opening pressure will be high. Treatment involves lifestyle modification with weight reduction, use of oral acetazolamide, and symptomatic treatment for headache. Patients with vision-threatening presentations may need surgical intervention with optic nerve sheath fenestration surgery. In this brief review, the authors describe the basics of disease etiopathogenesis, clinical features, and management of benign intracranial hypertension.
Spontaneous absorbed cataract: A rare presentation
Authors: Stephen Mary , Temkar Shreyas , Agarwal Disha , Periyandavan Jayasri 
Published: December 2024

Abstract
Spontaneous absorption of the clear or cataractous crystalline lens is a rare phenomenon associated with a history of trauma, uveitis, maternal rubella, and other hereditary conditions. We describe a case of spontaneous aphakia in a lady in her 80s, likely due to blunt trauma. Capsular bag and zonules were intact. With aphakic correction, the vision improved to 20/40. The patient was planned for a sulcus intraocular lens (IOL) placement. At 1-month post-surgery, she had a vision of 20/20 with well-centered IOL.
Evolving dynamics of E-learning in dental education in the post-COVID-19 era: Insights from the Mumbai Metropolitan Region
Authors: Patil Mithileshwari Bajirao , Ahire Manisha Sardar , Tupkari Jagdish , Maraimalai Nivedhitha 
Published: December 2024

ABSTRACT

Background:
Over the past decade, technological advancements, particularly in information and communication technology, have significantly impacted education. Due to this change, modern e-learning techniques must be used in dental education, albeit adoption is still uneven, particularly in India.

Aim:
In the urban districts of Mumbai and Navi Mumbai, this study sought to evaluate dentistry students’ opinions of online education. In particular, it aimed to determine the most popular resources, useful applications, and difficult problems encountered in virtual lectures. It also investigated the influence of video lectures, the inclination toward clinical posts, and the perceived level of interaction between virtual learning and conventional class settings.

Methodology:
Ethical approval was obtained, and a structured questionnaire comprising 19 questions was developed. Undergraduate dental students from seven colleges in Mumbai and Navi Mumbai participated. The digital questionnaire was distributed via E-mail and WhatsApp, with informed consent obtained for voluntary participation. Descriptive statistics were utilized for data analysis.

Results:
The study gathered 500 responses from dental students aged 18–24 years. Key findings revealed the prevalence of mobile devices, particularly those equipped with earphones, as the primary resource for e-learning. Zoom emerged as the favored online class platform. Challenges identified included background disturbances and content comprehension issues. Furthermore, there was a preference for visual case presentations and a strong inclination toward offline clinical postings, indicating pedagogical preferences.

Conclusion:
This study offers valuable insights into the dynamics of e-learning among dental students in metropolitan areas. It highlights the adaptability of students to digital platforms, with mobile phones being the predominant device for online lectures. Identified challenges call for potential solutions, while the observed pedagogical shifts emphasize the importance of balancing online and offline components in dental education.
Comparative evaluation of the effect of blue M active oxygen gel and Coe-Pack dressing on postoperative surgical depigmentation healing: A clinical study
Authors: Sharma Tusharika , Deshpande Neeraj , Shah Monali , Jha Rashmi 
Published: December 2024

ABSTRACT

Background:
The substantial saturation of the gingiva poses a significant esthetic issue for multiple individuals. Melanin saturation arises from melanin located within the gingival epithelium. Even though surgical depigmentation using a scalpel remains the favored system for managing gingiva pigmentation, it affects open wounds requiring specific dressing and management.

Aim:
The purpose of the study was to evaluate and compare the efficacy of Coe-Pack dressing and BlueM active oxygen gel in reducing pain after surgical depigmentation and evaluating gingival healing.

Materials and Methods:
Thirty-four nonsmoking individuals aged 20–38 years with physiologic gingival pigmentation index III and IV according to the Dummett–Gupta Oral Pigmentation index were enrolled in this split-mouth randomized clinical trial. These individuals were selected for an esthetic treatment for gingival hyperpigmentation of the gingiva. After depigmentation with a scalpel, the maxilla and mandible were separated to admit either BlueM gel or Coe-Pack as a dressing. A 1-week, 2 weeks, 3 weeks, and 4 weeks long follow-up period was observed, and indices, including the Dummet–Gupta Oral Pigmentation Index and re-epithelization index using toluidine blue dye, were evaluated and the Visual Analog Scale Pain index was also evaluated at 2 h, 24 h, 2 days, 3 days, 4 days, 5 days, 6 days, and 7 days follow-up period.

Results:
In total, 34 surgical sites were covered in this investigation. The pain indicator showed statistically significant variations from 1 day to 5 days later. After 3 weeks, the reepithelization index showed an advanced meaningful difference in the BlueM gel group.

Conclusion:
BlueM gel’s pain reduction, wound healing acceleration, and postoperative reepithelization make it a viable choice for the Coe-Pack dressing following gingival depigmentation.
The effect of acute toxicity test of red dragon Fruit (Hylocereus polyrhizus) peel extract on body weight and organ index of Wistar rats
Authors: Rizkifani Shoma , Wahdaningsih Sri , Untari Eka Kartika 
Published: December 2024

Background: Indonesian plant-based products are potential natural resources that can be developed as raw medicine materials, including dragon fruit peel extract. The peel of dragon fruit contains such high levels of antioxidants. The safety of dragon fruit plant-based products must be ensured by an acute toxicity test.
Objective: This study aimed to determine the relationship between dose and toxicity in acute oral administration of dragon fruit plant-based products on the heart, lungs, liver, spleen, and kidney organ index.
Method: Each six male and six female with a total of 24 rats were divided into four test groups, i.e., control group, 1250 mg/kgBW; 2500 mg/kgBW; and 5000 mg/kgBW. A single-dose test was given, and effect observation continued for 14 days. Body weight and organ index between male and female rats were compared statistically by the Independent T-test at a 95% confidence level.
Result: There were no animal deaths during the test, thus the LD50 value of dragon fruit peel extract was > 5000 mg/kgBW. In general, there was an increase in the body weight of animals. There was no significant difference in body weight among test groups in male (p 0.429 > 0.05) and female rats (p 0.721 < 0.05). There was also no statistical difference in organ index between the test and control groups (p > 0.05). The animals’ behaviours were also still normal manner.
Conclusion: The extract was practically non-toxic in acute treatment. The organs and the behaviour were not altered by the extract.
Factors affecting self-care behaviours of ulcer prevention and glycemic control among diabetes mellitus patients at type A hospital in Yogyakarta
Authors: Untari Eka Kartika , Andayani Tri Murti , Yasin Nanang Munif , Asdie Rizka Humardewayanti 
Published: December 2024

Background: One of the most detrimental complications of diabetic foot ulcers is largely influenced by glucose levels. To prevent diabetes-related complications and injuries, diabetic patients have to possess all the knowledge and behaviours required to perform regular self-care.
Objective: This study aimed to identify factors that influence the behaviour of diabetic patients to prevent diabetic foot ulcers.
Method: The study design was a cross-sectional survey of 57 outpatients with all criteria. The self-care knowledge and behaviour were measured by filling out questionnaires. A chi-square statistical test and multiple logistic regression were used to assess the magnitude of the predictor variables in behaviour and glycemic control. Moreover, difference tests were performed to assess differences between groups according to the level of behaviour.
Result: Out of 57 participants, 29 patients were having poor self-care behaviour. Of the 28 patients with uncontrolled glycemic, 12 had poor behaviour. The knowledge scores between poor and moderate behaviour showed a statistically significant difference (p = 0.046). Knowledge had a 2-fold impact on behaviour (p = 0.025). Additionally, the type (p = 0.011) and the number (p = 0.040) of anti-diabetic medications in prescriptions affected glycemic control.
Conclusion: Knowledge and behaviour of foot self-care and glycemic control are the key preventive factors.
AKTIVITAS HUMAS DALAM UPAYA PENYEBARLUASAN INFORMASI KEPADA MASYARAKAT PADA DPRD KOTA GORONTALO
Authors: Tolapa Minarni 
Published: December 2024

Penelitian ini bertujuan untuk mengetahui aktivitas Humas dalam upaya penyebaran informasi kepada masyarakat pada DPRD Kota Gorontalo. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif. dengan teknik analisis data menggunakan model interaktif Miles dan Huberman. Hasil kajian menunjukkan bahwa Aktivitas Humas DPRD Kota Gorontalo dalam menyebarluaskan informasi kepada masyarakat dilakukan dengan beberapa cara yaitu memberikan penerangan kepada masyarakat melalui penyebaran informasi dengan mempublikasikan setiap kegiatan-kegiatan dan kebijakan-kebijakan DPRD Kota melalui media sosial dan website dari DPRD Kota Gorontalo. Memberikan bantuan kepada media khususnya media massa dengan meberikan informasi-informasi seputar kegiatan yang akan dilakukan serta informasi terkait kebijakan-kebijakan yang diambil oleh DPRD Kota Gorontalo. Menyebarluaskan informasi terkait semua kegiatan yang ada dan terjadi di DPRD Kota Gorontalo kepada khalayak termasuk informasi mengenai pencapaian dan kinerja yang dihasilkan oleh DPRD Kota Gorontalo. Melakukan proses monitoring pendapat masyarakat dengan mengumpulkan informasi-informasi seputar pendapat masyarakat terhadap setiap informasi kegiatan-kegiatan yang dilakukan oleh DPRD Kota Gorntalo serta menjaring aspirasi masyarakat lewat informasi-informasi yang diberikan oleh wartawan.
Use of lactulose in the composition of blood cell cryopreservatives
Authors: Vlasov A. A. , Andrusenko S. F. , Anfinogenova O. I. , Elkanova A. B. , Kadanova A. A. , Sorokina U. E. , Rybchinskaya E. E. , Domenyuk D. A. 
Published: December 2024

Introduction. Cryopreservation allows for long-term conservation of biomaterials. The insufficient efficacy of available cryopreservatives and the toxicity of a number of cryocomponents renders the search for low-toxic biocompatible cryoagents highly relevant.Objective. Assessment of morphological and functional features of blood cells in a lactulose-based cryopreservative for storing whole blood at moderately low temperatures (minus 20 °C) using leukocyte, platelet, and erythrocytes parameters.Materials and methods. The study was conducted using peripheral venous blood of 30 female donor volunteers aged 18–23 years. Samples of peripheral venous blood were stabilized by 3-substituted potassium salt of ethylenediaminetetraacetic acid. The cryopreservative was prepared using a 0.9 % sodium chloride solution to maintain the isotonic concentration. Glycerin and dimethyl sulfoxide were used as cell-penetrating cryoprotectors; lactulose disaccharide was used as a non-penetrating cryoprotector. The composition of the obtained cryopreservative was optimized by varying the mass fractions of the components. Clinical blood tests were performed using a Gemalite 1270 automatic hematology analyzer. A computer cytomorphometric study was performed in the MEKOS-C2 hardware and software environment.Results. The conservation of blood samples using the developed cryopreservative for 24 h at a temperature of minus 20 °C increased the percentage of preserved leukocytes, erythrocytes, and platelets to 88.6±0.41 %, 92.1±0.31 %, and 91.4±0.52 %, respectively. The blood cells retained their physiological activity after thawing compared to blood samples stored at room temperature.Conclusions. The morphological and functional safety of blood cells in samples stored with the developed cryopreservative was revealed after 24 h of storage at minus 20°C. The advantages of this cryopreservative include the possibility of its long-term storage without loss of cryoprotective properties, stabilizing blood cells to the effects of sub-moderate low temperatures of minus 20 °C, the use of non-toxic lactulose disaccharide that does not penetrate into the cell. The developed cryopreservative proves effective in freezing conditions at minus 20 °C, being affordable in terms of cost (all components are manufactured in the Russian Federation). Further research in this direction will contribute to the development of safer blood donation approaches and reducing complications during transfusion of blood components.
Effect of combinations of antibiotics, phages, and depolymerase on biofilms of the drug-resistant Klebsiella pneumoniae strain
Authors: Krivulia A. O. , Gorodnichev R. B. , Kornienko M. A. , Abdraimova N. K. , Malakhova M. V. , Zaychikova M. V. , Shitikov E. A. 
Published: December 2024

Introduction. Klebsiella pneumoniae poses a serious threat to global healthcare due to the high proportion of multidrug-resistant isolates. Moreover, the formation of biofilms by bacteria significantly complicates the treatment of infections.Objective. To evaluate the effectiveness of the individual and combined action of antibiotics and bacteriophages or polysaccharide depolymerase on biofilms of a clinically significant strain K. pneumoniae.Materials and methods. The work used the K. pneumoniae strain with multidrug resistance (9faiz), 4 antibiotics of various classes (gentamicin, levofloxacin, meropenem and chloramphenicol), 3 bacteriophages of various genera (Dlv622, Seu621 and FRZ284), and 1 polysaccharide depolymerase (Dep622). Experiments were carried out on the formed biofilms by treating 24-hour K. pneumoniae films with antimicrobial agents individually or in combinations. The ability of the strain to form biofilms was evaluated by staining with crystalline violet. The comparison between the average optical density values was carried out using a t-test and was considered significant at p ≤ 0.05.Results. The individual use of antibiotics peak concentrations (Cmax) or depolymerase concentration of 100 MED (minimum effective dose — MED) did not lead to a significant decrease in biofilm biomass, whereas bacteriophages in a titer of 5×109 PFU/mL (plaque-forming unit per mL) statistically significantly reduced its biomass by 27–31% (p < 0.05) Most combinations of phages and antibiotics did not lead to a significant increase in the efficiency of biofilm destruction. Only the combination of phage FRZ284 with gentamicin statistically significantly showed an additional decrease in biofilm biomass by 27% (p < 0.05).Conclusions. The results show the need for individual selection of antimicrobial combinations to combat K. pneumoniae biofilms due to the possible effect of synergy and antagonism effects on the outcome of therapy.
Caracterización de los sistemas horto-frutícolas de la parroquia Colon del cantón Portoviejo
Authors: Fuentes Figueroa Tomas Robert , Narváez Campana Washington , Prado Moreira Melissa Nicole 
Published: December 2024

La presente investigación se planteó el objetivo de caracterizar los aspectos socioeconómicos y productivos de los sistemas horto-frutícolas en las comunidades de Pachinché, Sasay y Estancia Vieja, pertenecientes a la parroquia Colón del cantón Portoviejo. Para ello se realizó una encuesta a través del formulario a 80 productores horto-frutícolas de las comunidades de Estancia Vieja (26), Pachinche (26) y Sasay (28), Se aplicó la prueba no paramétrica utilizando el método estadístico chi cuadrado para identificar diferencias entre variables. Los resultados demuestra que 30 productores (38%) tienen un nivel de educación primaria, 48 (60%) tienen educación secundaria y 2 (3%) tienen educación superior, el valor p asociado a esta distribución es 0.804, lo que indica que no hay diferencia estadísticamente significativa en el nivel de instrucción entre las diferentes localidades. En la preferencia de siembra, el plátano es la hortaliza más sembrada, representando el 25% del total de respuestas. Le sigue la yuca con el 20%, el pimiento con el 18%, y el ají con el 19%. Esto sugiere una clara preferencia por estas hortalizas en las tres comunidades. La caracterización productiva de los cultivos horto-frutícolas del cantón Colón muestra que los productores, en su mayoría, trabajan en pequeñas parcelas de 0.5 a 1 hectáreas.