bluuebunny/crossref_metadata_2025_split huggingface dataset:
Participación de las familias de alumnado con apoyos y atenciones diferentes: un estudio en un contexto multicultural
Authors: Carmona Sáez Patricia , Martínez Joaquín Parra , Gomariz Vicente María Ángeles 
Published: January 2021

Familia y escuela colaborando en la educación del alumnado es un deseo y un derecho reconocido por la comunidad educativa. Se aborda, en un contexto multicultural en el sureste español, centrando la mirada de las familias cuyos hijos de Educación Infantil, Primaria y Secundaria Obligatoria reciben apoyo o atención diferentes. Busca conocer su implicación en la educación de los hijos y si existen diferencias respecto a la implicación de familias cuando sus hijos reciben, o no, apoyo o atención diferentes y en función de variables sociodemográficas. Han participado 3639 familias, se aplicó un cuestionario de elevada fiabilidad, con siete dimensiones de la participación. Las familias cuyos descendientes reciben apoyo o atención diferentes, atendiendo al modelo teórico que se defiende, se comunican más frecuentemente con los centros, muestran un elevado sentimiento de pertenencia, y valoran su participación formal en la escuela a través de órganos colegiados de manera más intensa.
What family and school have to collaborate in the education of our children and youth is a desire and a recognized right to families. It is the obligation of schools to promote family involvement in schools. It is approached, in a multicultural context in the south-east of Spain and focusing, the look of the families whose children of Preschool, Primary and Secondary Education have some specific need for educational support (NEAE). We pretend to know their involvement in the education of children and if there are differences regarding the involvement of families whose children do not have NEAE. 3639 families participated, a highly reliable questionnaire was applied, with seven dimensions of participation. The families whose descendants present NEAE communicate more frequently with the schools, show a high feeling of belonging, and value their formal participation in the school through collegiate ways more intensively.
Effectiveness of modifications to preadjusted appliance prescriptions based on racial dental characteristics assessed by the ABO Cast-Radiograph Evaluation: A propensity score matching study
Authors: Chu Yanhao , Zhang Lingling , Zhao Yatao , Yi Fang , Lu Yanqin 
Published: January 2021

Background
Because racial discrepancies in dental characteristics are known to exist, designing preadjusted appliances according to racial normal occlusion data would be expected to improve treatment results. However, whether modifications based on racial characteristics can improve treatment outcomes in the clinic remains to be investigated.

Methods
To study the influence of prescription type on treatment outcomes, 91 patients treated with Chinese or Roth prescription appliances were selected as an initial sample. Two groups of patients were selected by propensity score matching (1:1) to limit the effects of confounding factors, including age, sex, case complexity, and extraction plan. Discrepancy Index and cervical vertebral maturation values were used to quantify case complexity and patient age, respectively. After matching, the final sample of 60 patients consisted of two groups of 30 patients each: group 1 had been treated with a Chinese prescription appliance and group 2 had been treated with a Roth prescription appliance. ABO casts and radiograph evaluation (CR-Eval) and lateral cephalograms were utilized to compare the treatment outcomes of the two groups.

Results
The total ABO scores of groups 1 and 2 were 22.03 and 23.87, respectively. There were no significant differences between the two groups in total ABO score or in seven other sub-scores; however, there was a significant difference between the two groups in mandibular canine alignment score.

Conclusions
There are no significant differences in overall treatment outcomes between the Chinese and Roth prescription appliances. The Chinese prescription yielded better alignment results in the mandibular canine for Chinese patients.
RNA sequencing analysis of FGF2-responsive transcriptome in skin fibroblasts
Authors: Wu Baojin , Tang Xinjie , Zhou Zhaoping , Ke Honglin , Tang Shao , Ke Ronghu 
Published: January 2021

Background
Fibroblast growth factor 2 (FGF2) is a highly pleiotropic cytokine with antifibrotic activity in wound healing. During the process of wound healing and fibrosis, fibroblasts are the key players. Although accumulating evidence has suggested the antagonistic effects of FGF2 in the activation process of fibroblasts, the mechanisms by which FGF2 hinders the fibroblast activation remains incompletely understood. This study aimed to identify the key genes and their regulatory networks in skin fibroblasts treated with FGF2.

Methods
RNA-seq was performed to identify the differentially expressed mRNA (DEGs) and lncRNA between FGF2-treated fibroblasts and control. DEGs were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Furthermore, the networks between mRNAs and lncRNAs were constructed by Pearson correlation analysis and the networkanalyst website. Finally, hub genes were validated by real time-PCR.

Results
Between FGF2-treated fibroblasts and control fibroblasts, a total of 1475 DEGs was obtained. These DEGs were mainly enriched in functions such as the ECM organization, cell adhesion, and cell migration. They were mainly involved in ECM-receptor interaction, PI3K-Akt signaling, and the Hippo pathway. The hub DEGs included COL3A1, COL4A1, LOX, PDGFA, TGFBI, and ITGA10. Subsequent real-time PCR, as well as bioinformatics analysis, consistently demonstrated that the expression of ITGA10 was significantly upregulated while the other five DEGs (COL3A1, COL4A1, LOX, PDGFA, TGFBI) were downregulated in FGF2-treated fibroblasts. Meanwhile, 213 differentially expressed lncRNAs were identified and three key lncRNAs (HOXA-AS2, H19, and SNHG8) were highlighted in FGF2-treated fibroblasts.

Conclusion
The current study comprehensively analyzed the FGF2-responsive transcriptional profile and provided candidate mechanisms that may account for FGF2-mediated wound healing.
Hyperlipidic Diet-induced Obesity Increased Proliferative Signals- AR, ERK1/2- on Mice Prostate, Which can be Restored through Physical Training
Authors: Leite João Vitor Pereira , Calaça Daniela Cristina de Cario , Nogueira Pedro Augusto Silva , Zanon Renata Graciele , Ribeiro Daniele Lisboa 
Published: January 2021

Aims: To evaluate the effects of hyperlipidic diet on the mouse prostate and also investigate if physical exercise is able to restore such effects.
Methodology: Adult male Swiss mice were fed with a balanced (ND) or hyperlipidic diet (45% saturated fat, HD) for 16 weeks. Half were submitted to a sedentary (NDS and HDS) or exercise routine (swimming- NDE and HDE) for 8 weeks. Then, the prostate was analyzed by immunoreactions (proliferating cell nuclear antigen- PCNA, androgen receptor- AR, and estrogen receptor-ERβ), western blotting (ERK 1/2), and caspase-3 activity.
Results: We found that saturated fat uptake promoted 16% weight gain, increased fat-mass and hyperglycaemia, as well as reduced testosterone levels. In addition, HD atrophied prostate secretory epithelium and stimulated cell proliferation through higher expression of AR and activation of ERK signaling. Additionally, saturated fat reduced prostatic ERβ content. Physical exercise per se promoted an anabolic effect by increasing testosterone and stimulating cell proliferation in the prostate of sedentary animals. Finally, exercise was able to restore the proliferative signals caused by the hyperlipidic diet on prostate.
Conclusion: We suggest that the combination of hyperlipidic diet and sedentary lifestyle could negatively affected some prostate stimulating pathways that could trigger proliferative diseases in mice and physical exercise may be an interesting strategy to reverse such effects.
Simultaneous Effects of the Climate Change and the Recent Hydromorphological Modification of Vridi Channel (Côte d'Ivoire) on Some Its Hydrochemical Characteristics
Authors: Samuel N'da , Konan Yao Marcel , Albert Trokourey 
Published: January 2021

This work aims to assess the simultaneous effects of the climate change and the hydromorphological modification of Vridi channel on its hydrochemistry. To best estimate, this fact, the seasonal dynamic of the particle size distribution, pH, redox potential, salinity, conductivity, moisture and organic matter contents of Vridi channel sediments have been followed and compared during two different annual periods, where the climate and the hydromorphology of this estuary have been different. The first annual period, covering the period from April 2014 to March 2015, has been characterized by a climatic regime close to the climatic normal of the study area and, this channel had its former hydromorphology. The second period annual, covering the period from October 2018 to September 2019, has been marked by a disruption of the climatic regime throughout Côte d'Ivoire, and this channel presented its modified hydromorphology.
A monthly sampling has been done in this channel during each annual period. All These physical and chemical parameters have been determined by the corresponding AFNOR standards.
Results have shown that these superficial sediments, with a predominantly sandy texture over the period from April 2014 to March 2015, have presented a texture predominantly of silt and clays over the period from October 2018 to September 2019. The climate change and the recent hydromorphological modification of this ecosystem had simultaneous very few effects on their pH and redox potential over the study period. On the other hand, they have caused an important increase in their salinity, moisture and organic matter contents and, a decrease in their electrical conductivity over the period from October 2018 to September 2019 relative to those determined in these substrates over the period of April 2014 to March 2015. This fact has certainly affected its biodiversity, especially that of its benthic fauna.
Nitrogen-phosphate Fertilizers Based on Activation of Phosphorite Powder with Partially Ammoniated Mix of Phosphoric and Sulphuric Acids
Authors: Rasulov A. A. , Namazov Sh. S. , Sultonov B. E. 
Published: January 2021

In this article obtaining complex nitrogen-phosphate fertilizers based on activation of phosphorite powder with partially ammoniated mix of phosphoric and sulphuric acids have been studied. In order to reduce the foaming of the process, for the first time a partially ammoniated mix of acids was used. The optimal technological parameters for activation phosphorite powder with partially neutralized mixes of sulphuric and phosphoric acids are the followings: the mix of sulphuric and phosphoric acids with a ratio of SО3:Р2О5 = 1.2; рН of acids – 2.5; weight ratio of ammonium sulphate-phosphate slurry towards phosphorite powder is 100 : 20; temperature is 60°С; duration is 30 min. The composition nitrogen-phosphate fertilizers obtained in optimal condition contains (wt., %): N – 11.55; Р2О5total -24.61; Р2О5acceptable by citric acid -21.66; Р2О5 acceptable by EDTA -20.24; Р2О5water-soluble -13.02; CaOtotal -13.59; СаОacceptable by citric acid -11.43. In that condition, granulated products of nitrogen-phosphate can be produced with high strength. The advantage of offered promising technology concludes in reduction two times expenditure of the most expensive ammonia in comparison with ammonium sulphate production and an increase in gross domestic product.
Optimization of Extraction and Dyeing Conditions of Natural Dye from Ratanjot Roots Using Ultrasonic Waves
Authors: Devi Oinam Roselyn , Bains Sandeep , Grewal Sumeet 
Published: January 2021

The present work involves the optimization of extraction and dyeing recipes to standardize the procedure for natural dye obtained from the roots of Ratanjot (Onosma echiodes) using ultrasonic waves. The resultant dye obtained at optimized extraction conditions was applied on wool fabric to study the effect of temperature, dye concentration, time and dyeing pH. Optical density and colour strength (K/S value) were studied for evaluation of optimum extraction and dyeing conditions. It was observed that extraction and dyeing parameters have significant effect on colour characteristics of dyed wool fabric. The optimized extraction conditions were; dye extraction pH 7, extraction time 60 min and temperature 60ºC while optimized dyeing parameters were; dyeing temperature 60°C, dye concentration 2 g/g, dyeing time 75 min and dyeing pH 5. It was also observed that the optimum dye extraction time and pH is same with the conventional heating method but there is reduction in the temperature (60°C), dyeing time and dye concentration consumption in ultrasonic extraction and dyeing method, thus saves the energy, time and amount of dye requirement. Therefore, ultrasound wave represents a promising method for increasing diffusion of dye by the effect of cavitation, as well as for improving the effectiveness of processes as compare to conventional heating method.
Automatic couch position calculation using eclipse scripting for external beam radiotherapy
Authors: Wang Hesheng , Rea Anthony , Rudek Benedikt , Chen Ting , McCarthy Allison , Barbee David 
Published: January 2021

AbstractPurposeThe treatment couch position of a patient in external beam radiation therapy (EBRT) is usually acquired during initial treatment setup. This procedure has shown potential failure modes leading to near misses and adverse events in radiation treatment. This study aims to develop a method to automatically determine the couch position before setting up a patient for initial treatment.MethodsThe Qfix couch‐tops (kVue and DoseMax) have embedded reference marks (BBs) indicating its index levels and couch centerline. With the ESAPI, a C# script was programmed to automatically find the couch‐top and embedded BBs in the planning CT and derive the treatment couch position according to treatment isocenter of a plan. Couch positions of EBRT plans with the kVue couch‐top and SBRT plans using the DoseMax were calculated using the script. The calculation was evaluated by comparing calculated positions with couch coordinates captured during the initial treatment setup after image guidance. The calculations were further compared with daily treatment couch positions post image‐guided adjustment for each treatment fraction.ResultsFor plans using the kVue couch‐top for various treatment sites, the median (5–95 percentiles) differences between calculated and captured couch positions were 0.1 (−0.2 – 0.9), 0.5 (−1.1–2.0), 0.10 (−1.3–1.3) cm in the vertical, longitudinal, and lateral direction respectively. For the DoseMax couch‐top, the median differences were 0.1 (−0.2–0.7), 0.2 (−0.3–1.1), and 0.2 (−0.7–0.9) cm in respective direction. The calculated positions were within 1 and 2 cm from the mean fraction positions for 95% patients on DoseMax and kVue couch‐top respectively.ConclusionsA method that automatically and accurately calculates treatment couch position from simulation CT was implemented in Varian Eclipse for Qfix couch‐tops. This technique increases the efficiency of patient setup and enhances patient safety by reducing the risks of positioning errors.
Association of Renal Arteriosclerosis With Atherosclerotic Cardiovascular Disease Risk in Lupus Nephritis
Authors: Garg Shivani , Raval Amish N. , Hansen Karen E. , Zhong Weixiong , Huang Yabing , Smith Maureen , Panzer Sarah E. , Bartels Christie M. 
Published: January 2021

ObjectiveLupus nephritis (LN) predicts a 9‐fold higher atherosclerosis cardiovascular disease (ASCVD) risk, highlighting the urgent need to target ASCVD prevention. Studies in IgA nephropathy reported that severe renal arteriosclerosis (r‐ASCL) in diagnostic biopsies strongly predicted ASCVD risk. We recently found that 50% of LN pathology reports overlooked r‐ASCL reporting, which could explain prior negative LN ASCVD risk studies. The present study was undertaken to examine associations between a composite of reported and overread r‐ASCL and ASCVD events in LN.MethodsData were abstracted from all LN patients who underwent diagnostic biopsy between 1994 and 2017, including demographic information, ASCVD risk factors, and pathology reports at the time of LN diagnosis. We manually validated all incident ASCVD events. We overread 25% of the biopsies to grade r‐ASCL using the Banff criteria. We supplemented the overread r‐ASCL grade, when available, to determine the composite of reported and overread r‐ASCL grade.ResultsAmong 189 incident LN patients, 78% were female, 73% White, and the median age was 25 years. Overall, 31% had any reported r‐ASCL, and 7% had moderate‐to‐severe r‐ASCL. After incorporating systematically re‐examined r‐ASCL grade, the prevalence of any and moderate‐to‐severe r‐ASCL increased to 39% and 12%, respectively. We found 22 incident ASCVD events over 11 years of follow‐up. Using a composite of reported and overread r‐ASCL grade, we found that severe r‐ASCL in diagnostic LN biopsies was associated with 9‐fold higher odds of ASCVD.ConclusionSevere r‐ASCL can predict ASCVD in LN; therefore, larger studies are required to systematically report r‐ASCL and examine ASCVD associations.
Noninvasive Evaluation of HepaRG Aggregates during Drug‐Induced Intrahepatic Cholestasis Using Optical Coherence Tomography
Authors: Sonoi Rie , Yamakawa Takeshi , Nakatani Noriyuki , Kokubo Masahiko , Hagihara Yoshihisa 
Published: January 2021

AbstractIntrahepatic cholestasis represents a typical manifestation of drug‐induced liver injury. Many researches have been made to understand the drug‐induced cholestasis using human cell based in vitro 3D model. Although noninvasive observation of 3D model will help unveil the hidden mechanism of this phenomenon, there have been few studies using the noninvasive methods. This study has attempted to evaluate the potential of noninvasive optical coherence tomography (OCT) combined with confocal laser scanning microscopy using the aggregates of a differentiated human hepatic cell line. From immunofluorescence staining images, the aggregates during drug‐induced cholestasis are divided into three groups: aggregates of mature phase (type I), immature phase (type II), and death phase (type III). OCT data reveal that different distributions of gray levels of OCT images are observed between heterogeneous (type I and II) and homogeneous cell populations (type III). A threshold based on gray levels of OCT data in each phenotype is determined, and the data can distinguish type III aggregates from the others. The results suggest that OCT data provide valuable information for noninvasively and quantitatively determining the transition of different types of cell population, i.e., from type I and II to type III, in drug‐induced intrahepatic cholestasis processes.
Thylakoid Membranes with Unique Photosystems Used to Simultaneously Produce Self‐Supplying Oxygen and Singlet Oxygen for Hypoxic Tumor Therapy
Authors: Cheng Yan , Zheng Runxiao , Wu Xiaqing , Xu Keqiang , Song Panpan , Wang Yanjing , Yan Jiao , Chen Rui , Li Xi , Zhang Haiyuan 
Published: January 2021

AbstractPhotodynamic therapy (PDT) efficacy has been dramatically limited by the insufficient oxygen (O2) level in hypoxic tumors. Although various PDT nanosystems have been designed to deliver or produce O2 in support of reactive oxygen species (ROS) formation, the feature of asynchronous O2 generation and ROS formation still results in the low PDT efficacy. Herein, thylakoid membranes (TM) of chloroplasts is decorated on upconversion nanoparticles (UCNPs) to form UCTM NPs, aiming at realizing spatiotemporally synchronous O2 self‐supply and ROS production. Upon 980 nm laser irradiation, UC NPs can emit the red light to activate both photosystem‐I and photosystem‐II of TM, the Z‐scheme electronic structure of which facilitates water to produce O2 and further to singlet oxygen (1O2). UCTM NPs showed excellent biocompatibility, and can effectively remove the hypoxic tumor of mice upon 980 nm laser irradiation. This study develops a new PDT strategy for hypoxic tumor therapy based on photosynthesis.
A Graded, Porous Composite of Natural Biopolymers and Octacalcium Phosphate Guides Osteochondral Differentiation of Stem Cells
Authors: Amann Elisabeth , Amirall Amisel , Franco Albina R. , Poh Patrina S. P. , Sola Dueñas Francisco J. , Fuentes Estévez Gastón , Leonor Isabel B. , Reis Rui L. , van Griensven Martijn , Balmayor Elizabeth R. 
Published: January 2021

AbstractLesions involving the osteochondral unit are difficult to treat. Biomimetic scaffolds are previously shown as promising alternative. Such devices often lack multiple functional layers that mimic bone, cartilage, and the interface. In this study, multilayered scaffolds are developed based on the use of natural extracellular matrix (ECM)‐like biopolymers. Particular attention is paid to obtain a complex matrix that mimics the native osteochondral transition. Porous, sponge‐like chitosan‐collagen‐octacalcium phosphate (OCP) scaffolds are obtained. Collagen content increases while the amount of OCP particles decreases toward the cartilage layer. The scaffolds are bioactive as a mineral layer is deposited containing hydroxyapatite at the bony side. The scaffolds stimulate proliferation of human adipose‐derived mesenchymal stem cells, but the degree of proliferation depends on the cell seeding density. The scaffolds give rise to a zone‐specific gene expression. RUNX2, COL1A1, BGLAP, and SPP1 are upregulated in the bony layer of the scaffold. SOX9 is upregulated concomitant with COL2A1 expression in the cartilage zone. Mineralization in presence of the cells is prominent in the bone area with Ca and P steadily increasing over time. These results are encouraging for the fabrication of biomimetic scaffolds using ECM‐like materials and featuring gradients that mimic native tissues and their interface.
A Patternable and In Situ Formed Polymeric Zinc Blanket for a Reversible Zinc Anode in a Skin‐Mountable Microbattery
Authors: Zhu Minshen , Hu Junping , Lu Qiongqiong , Dong Haiyun , Karnaushenko Dmitriy D. , Becker Christian , Karnaushenko Daniil , Li Yang , Tang Hongmei , Qu Zhe , Ge Jin , Schmidt Oliver G. 
Published: January 2021

AbstractOwing to their high safety and reversibility, aqueous microbatteries using zinc anodes and an acid electrolyte have emerged as promising candidates for wearable electronics. However, a critical limitation that prevents implementing zinc chemistry at the microscale lies in its spontaneous corrosion in an acidic electrolyte that causes a capacity loss of 40% after a ten‐hour rest. Widespread anti‐corrosion techniques, such as polymer coating, often retard the kinetics of zinc plating/stripping and lack spatial control at the microscale. Here, a polyimide coating that resolves this dilemma is reported. The coating prevents corrosion and hence reduces the capacity loss of a standby microbattery to 10%. The coordination of carbonyl oxygen in the polyimide with zinc ions builds up over cycling, creating a zinc blanket that minimizes the concentration gradient through the electrode/electrolyte interface and thus allows for fast kinetics and low plating/stripping overpotential. The polyimide's patternable feature energizes microbatteries in both aqueous and hydrogel electrolytes, delivering a supercapacitor‐level rate performance and 400 stable cycles in the hydrogel electrolyte. Moreover, the microbattery is able to be attached to human skin and offers strong resistance to deformations, splashing, and external shock. The skin‐mountable microbattery demonstrates an excellent combination of anti‐corrosion, reversibility, and durability in wearables.