bluuebunny/crossref_metadata_2025_split huggingface dataset:
Private and rateless adaptive coded matrix-vector multiplication
Authors: Bitar Rawad , Xing Yuxuan , Keshtkarjahromi Yasaman , Dasari Venkat , El Rouayheb Salim , Seferoglu Hulya 
Published: January 2021

AbstractEdge computing is emerging as a new paradigm to allow processing data near the edge of the network, where the data is typically generated and collected. This enables critical computations at the edge in applications such as Internet of Things (IoT), in which an increasing number of devices (sensors, cameras, health monitoring devices, etc.) collect data that needs to be processed through computationally intensive algorithms with stringent reliability, security and latency constraints. Our key tool is the theory of coded computation, which advocates mixing data in computationally intensive tasks by employing erasure codes and offloading these tasks to other devices for computation. Coded computation is recently gaining interest, thanks to its higher reliability, smaller delay, and lower communication costs. In this paper, we develop a private and rateless adaptive coded computation (PRAC) algorithm for distributed matrix-vector multiplication by taking into account (1) the privacy requirements of IoT applications and devices, and (2) the heterogeneous and time-varying resources of edge devices. We show that PRAC outperforms known secure coded computing methods when resources are heterogeneous. We provide theoretical guarantees on the performance of PRAC and its comparison to baselines. Moreover, we confirm our theoretical results through simulations and implementations on Android-based smartphones.
Orthogonality in smooth countably normed spaces
Authors: Tawfeek Sarah , Faried Nashat , El-Sharkawy H. A. 
Published: January 2021

AbstractWe generalize the concepts of normalized duality mapping, J-orthogonality and Birkhoff orthogonality from normed spaces to smooth countably normed spaces. We give some basic properties of J-orthogonality in smooth countably normed spaces and show a relation between J-orthogonality and metric projection on smooth uniformly convex complete countably normed spaces. Moreover, we define the J-dual cone and J-orthogonal complement on a nonempty subset S of a smooth countably normed space and prove some basic results about the J-dual cone and the J-orthogonal complement of S.
The base of warped product submanifolds of Sasakian space forms characterized by differential equations
Authors: Ali Akram , Agrawal Ravi P. , Mofarreh Fatemah , Alluhaibi Nadia 
Published: January 2021

AbstractIn the present paper, we find some characterization theorems. Under certain pinching conditions on the warping function satisfying some differential equation, we show that the base of warped product submanifolds of a Sasakian space form $\widetilde{M}^{2m+1}(\epsilon )$

M
˜

2
m
+
1

(
ϵ
)
is isometric either to a Euclidean space $\mathbb{R}^{n}$

R
n

or a warped product of a complete manifold N and the Euclidean line $\mathbb{R}$
R
.
Identification of microbial signatures linked to oilseed rape yield decline at the landscape scale
Authors: Hilton Sally , Picot Emma , Schreiter Susanne , Bass David , Norman Keith , Oliver Anna E. , Moore Jonathan D. , Mauchline Tim H. , Mills Peter R. , Teakle Graham R. , Clark Ian M. , Hirsch Penny R. , van der Gast Christopher J. , Bending Gary D. 
Published: January 2021

Abstract
Background
The plant microbiome plays a vital role in determining host health and productivity. However, we lack real-world comparative understanding of the factors which shape assembly of its diverse biota, and crucially relationships between microbiota composition and plant health. Here we investigated landscape scale rhizosphere microbial assembly processes in oilseed rape (OSR), the UK’s third most cultivated crop by area and the world's third largest source of vegetable oil, which suffers from yield decline associated with the frequency it is grown in rotations. By including 37 conventional farmers’ fields with varying OSR rotation frequencies, we present an innovative approach to identify microbial signatures characteristic of microbiomes which are beneficial and harmful to the host.

Results
We show that OSR yield decline is linked to rotation frequency in real-world agricultural systems. We demonstrate fundamental differences in the environmental and agronomic drivers of protist, bacterial and fungal communities between root, rhizosphere soil and bulk soil compartments. We further discovered that the assembly of fungi, but neither bacteria nor protists, was influenced by OSR rotation frequency. However, there were individual abundant bacterial OTUs that correlated with either yield or rotation frequency. A variety of fungal and protist pathogens were detected in roots and rhizosphere soil of OSR, and several increased relative abundance in root or rhizosphere compartments as OSR rotation frequency increased. Importantly, the relative abundance of the fungal pathogen Olpidium brassicae both increased with short rotations and was significantly associated with low yield. In contrast, the root endophyte Tetracladium spp. showed the reverse associations with both rotation frequency and yield to O. brassicae, suggesting that they are signatures of a microbiome which benefits the host. We also identified a variety of novel protist and fungal clades which are highly connected within the microbiome and could play a role in determining microbiome composition.

Conclusions
We show that at the landscape scale, OSR crop yield is governed by interplay between complex communities of both pathogens and beneficial biota which is modulated by rotation frequency. Our comprehensive study has identified signatures of dysbiosis within the OSR microbiome, grown in real-world agricultural systems, which could be used in strategies to promote crop yield.
Quantifying fluorescent glycan uptake to elucidate strain-level variability in foraging behaviors of rumen bacteria
Authors: Klassen Leeann , Reintjes Greta , Tingley Jeffrey P. , Jones Darryl R. , Hehemann Jan-Hendrik , Smith Adam D. , Schwinghamer Timothy D. , Arnosti Carol , Jin Long , Alexander Trevor W. , Amundsen Carolyn , Thomas Dallas , Amann Rudolf , McAllister Tim A. , Abbott D. Wade 
Published: January 2021

AbstractGut microbiomes, such as the microbial community that colonizes the rumen, have vast catabolic potential and play a vital role in host health and nutrition. By expanding our understanding of metabolic pathways in these ecosystems, we will garner foundational information for manipulating microbiome structure and function to influence host physiology. Currently, our knowledge of metabolic pathways relies heavily on inferences derived from metagenomics or culturing bacteria in vitro. However, novel approaches targeting specific cell physiologies can illuminate the functional potential encoded within microbial (meta)genomes to provide accurate assessments of metabolic abilities. Using fluorescently labeled polysaccharides, we visualized carbohydrate metabolism performed by single bacterial cells in a complex rumen sample, enabling a rapid assessment of their metabolic phenotype. Specifically, we identified bovine-adapted strains ofBacteroides thetaiotaomicronthat metabolized yeast mannan in the rumen microbiome ex vivo and discerned the mechanistic differences between two distinct carbohydrate foraging behaviors, referred to as “medium grower” and “high grower.” Using comparative whole-genome sequencing, RNA-seq, and carbohydrate-active enzyme fingerprinting, we could elucidate the strain-level variability in carbohydrate utilization systems of the two foraging behaviors to help predict individual strategies of nutrient acquisition. Here, we present a multi-faceted study using complimentary next-generation physiology and “omics” approaches to characterize microbial adaptation to a prebiotic in the rumen ecosystem.
Coexistence patterns of soil methanogens are closely tied to methane generation and community assembly in rice paddies
Authors: Li Dong , Ni Haowei , Jiao Shuo , Lu Yahai , Zhou Jizhong , Sun Bo , Liang Yuting 
Published: January 2021

Abstract
Background
Soil methanogens participate in complex interactions, which determine the community structures and functions. Studies continue to seek the coexistence patterns of soil methanogens, influencing factors and the contribution to methane (CH4) production, which are regulated primarily by species interactions, and the functional significance of these interactions. Here, methane emissions were measured in rice paddies across the Asian continent, and the complex interactions involved in coexistence patterns of methanogenic archaeal communities were represented as pairwise links in co-occurrence networks.

Results
The network topological properties, which were positively correlated with mean annual temperature, were the most important predictor of CH4 emissions among all the biotic and abiotic factors. The methanogenic groups involved in commonly co-occurring links among the 39 local networks contributed most to CH4 emission (53.3%), much higher than the contribution of methanogenic groups with endemic links (36.8%). The potential keystone taxa, belonging to Methanobacterium, Methanocella, Methanothrix, and Methanosarcina, possessed high linkages with the methane generation functional genes mcrA, fwdB, mtbA, and mtbC. Moreover, the commonly coexisting taxa showed a very different assembly pattern, with ~ 30% determinism and ~ 70% stochasticity. In contrast, a higher proportion of stochasticity (93~99%) characterized the assembly of endemically coexisting taxa.

Conclusions
These results suggest that the coexistence patterns of microbes are closely tied to their functional significance, and the potential importance of common coexistence further imply that complex networks of interactions may contribute more than species diversity to soil functions.
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
Authors: Becherini Pamela , Caffa Irene , Piacente Francesco , Damonte Patrizia , Vellone Valerio G. , Passalacqua Mario , Benzi Andrea , Bonfiglio Tommaso , Reverberi Daniele , Khalifa Amr , Ghanem Moustafa , Guijarro Ana , Tagliafico Luca , Sucameli Marzia , Persia Angelica , Monacelli Fiammetta , Cea Michele , Bruzzone Santina , Ravera Silvia , Nencioni Alessio 
Published: January 2021

Abstract
Background
Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through which SIRT6 exerts its pro-oncogenic effects in BC remain unclear. Here, we sought to define the role of SIRT6 in BC cell metabolism and in mouse polyoma middle T antigen (PyMT)-driven mammary tumors.

Methods
We evaluated the effect of a heterozygous deletion of Sirt6 on tumor latency and survival of mouse mammary tumor virus (MMTV)-PyMT mice. The effect of SIRT6 silencing on human BC cell growth was assessed in MDA-MB-231 xenografts. We also analyzed the effect of Sirt6 heterozygous deletion, of SIRT6 silencing, and of the overexpression of either wild-type (WT) or catalytically inactive (H133Y) SIRT6 on BC cell pyruvate dehydrogenase (PDH) expression and activity and oxidative phosphorylation (OXPHOS), including respiratory complex activity, ATP/AMP ratio, AMPK activation, and intracellular calcium concentration.

Results
The heterozygous Sirt6 deletion extended tumor latency and mouse survival in the MMTV-PyMT mouse BC model, while SIRT6 silencing slowed the growth of MDA-MB-231 BC cell xenografts. WT, but not catalytically inactive, SIRT6 enhanced PDH expression and activity, OXPHOS, and ATP/AMP ratio in MDA-MB-231 and MCF7 BC cells. Opposite effects were obtained by SIRT6 silencing, which also blunted the expression of genes encoding for respiratory chain proteins, such as UQCRFS1, COX5B, NDUFB8, and UQCRC2, and increased AMPK activation in BC cells. In addition, SIRT6 overexpression increased, while SIRT6 silencing reduced, intracellular calcium concentration in MDA-MB-231 cells. Consistent with these findings, the heterozygous Sirt6 deletion reduced the expression of OXPHOS-related genes, the activity of respiratory complexes, and the ATP/AMP ratio in tumors isolated from MMTV-PyMT mice.

Conclusions
Via its enzymatic activity, SIRT6 enhances PDH expression and activity, OXPHOS, ATP/AMP ratio, and intracellular calcium concentration, while reducing AMPK activation, in BC cells. Thus, overall, SIRT6 inhibition appears as a viable strategy for preventing or treating BC.
Dispositional individual differences in cognitive effort investment: establishing the core construct
Authors: Kührt Corinna , Pannasch Sebastian , Kiebel Stefan J. , Strobel Alexander 
Published: January 2021

AbstractBackgroundIndividuals tend to avoid effortful tasks, regardless of whether they are physical or mental in nature. Recent experimental evidence is suggestive of individual differences in the dispositional willingness to invest cognitive effort in goal-directed behavior. The traits need for cognition (NFC) and self-control are related to behavioral measures of cognitive effort discounting and demand avoidance, respectively. Given that these traits are only moderately related, the question arises whether they reflect a common core factor underlying cognitive effort investment. If so, the common core of both traits might be related to behavioral measures of effort discounting in a more systematic fashion. To address this question, we aimed at specifying a core construct of cognitive effort investment that reflects dispositional differences in the willingness and tendency to exert effortful control.MethodsWe conducted two studies (N = 613 andN = 244) with questionnaires related to cognitive motivation and effort investment including assessment of NFC, intellect, self-control and effortful control. We first calculated Pearson correlations followed by two mediation models regarding intellect and its separate aspects,seekandconquer, as mediators. Next, we performed a confirmatory factor analysis of a hierarchical model of cognitive effort investment as second-order latent variable. First-order latent variables were cognitive motivation reflecting NFC and intellect, and effortful self-control reflecting self-control and effortful control. Finally, we calculated Pearson correlations between factor scores of the latent variables and general self-efficacy as well as traits of the Five Factor Model of Personality for validation purposes.ResultsOur findings support the hypothesized correlations between the assessed traits, where the relationship of NFC and self-control is specifically mediated via goal-directedness. We established and replicated a hierarchical factor model of cognitive motivation and effortful self-control that explains the shared variance of the first-order factors by a second-order factor of cognitive effort investment.ConclusionsTaken together, our results integrate disparate literatures on cognitive motivation and self-control and provide a basis for further experimental research on the role of dispositional individual differences in goal-directed behavior and cost–benefit-models.
First insights into the archaeometric analysis of the Los Amores Mosaic in Cástulo (Linares, Spain): the Judgement of Paris
Authors: Sánchez Alberto , Tuñón José , Montejo Manuel , Amate Pilar , Ceprián Bautista , Rousaki Anastasia , Costa Mafalda , Saelens Delphine , Lycke Sylvia , Vandenabeele Peter 
Published: January 2021

Abstract
This paper discusses results obtained from in situ analysis of the tesserae of the Roman mosaic of Los Amores (Cástulo site, Linares, Spain) dating back to the turn of the 1st to the 2nd century AD. Specifically, it focuses on the scene The Judgment of Paris. In view of the exceptional state of preservation of the mosaic, from which very few tesserae had fallen off, non-invasive methods with portable Micro Raman Spectroscopy (MRS) and hand-held X-ray fluorescence (hXRF) and data assessment by use of principal component analysis and binary representations were selected. The results obtained allow to evaluate both the analytical method and the portable equipment used, as well as to classify the raw materials, the colouring agents and the opacifiers used. MRS analysis proved crucial for the identification of stone tesserae (ironstones, carbonate and siliciclastic rocks) and for the identification of the type of glasses used (soda-lime-silicate and lead type glasses) based on the analysis of two detached tesserae. hXRF analysis of the glass tesserae identified both colouring agents (Co, Cu, Pb, Zn) and opacifiers (calcium antimonate). The data obtained lend themselves to an assessment of the degradation process that threaten the integrity of the mosaic. The identification of tessera made of specific stone materials (especially ironstone) and of lead glass tesserae suggest the existence of a mosaic workshop in the Upper Guadalquivir (Eastern Andalusia, Spain).
Evaluation of the contribution of tropical cyclone seeds to changes in tropical cyclone frequency due to global warming in high-resolution multi-model ensemble simulations
Authors: Yamada Yohei , Kodama Chihiro , Satoh Masaki , Sugi Masato , Roberts Malcolm J. , Mizuta Ryo , Noda Akira T. , Nasuno Tomoe , Nakano Masuo , Vidale Pier Luigi 
Published: January 2021

AbstractPrevious projections of the frequency of tropical cyclone genesis due to global warming, even in terms of sign of the change, depends on the chosen model simulation. Here, we systematically examine projected changes in tropical cyclones using six global atmospheric models with medium-to-high horizontal resolutions included in the sixth phase of the Coupled Model Intercomparison Project/High-Resolution Model Intercomparison Project. Changes in the frequency of tropical cyclone genesis could be broken down into the contributions from (i) the tropical cyclone seed, a depression having a closed contour of sea level pressure with a warm core and (ii) the survival rate, the ratio of the frequency of tropical cyclone genesis to that of tropical cyclone seeds. The multi-model ensemble mean indicates that tropical cyclone genesis frequencies are significantly decreased during the period 1990–2049, which is attributable to changes in tropical cyclone seeds. Analysis of the individual models shows that although most models project a more or less decreasing trend in tropical cyclone genesis frequencies and seeds, the survival rate also contributes to the result in some models. The present study indicates the usefulness of decomposition into the frequency of the tropical cyclone seeds and the survival rate to understand the cause of uncertainty in projected frequencies of tropical cyclone genesis.
A hybrid metaheuristic for solving asymmetric distance-constrained vehicle routing problem
Authors: Ban Ha-Bang , Nguyen Phuong Khanh 
Published: January 2021

AbstractThe Asymmetric Distance-Constrained Vehicle Routing Problem (ADVRP) is NP-hard as it is a natural extension of the NP-hard Vehicle Routing Problem. In ADVRP problem, each customer is visited exactly once by a vehicle; every tour starts and ends at a depot; and the traveled distance by each vehicle is not allowed to exceed a predetermined limit. We propose a hybrid metaheuristic algorithm combining the Randomized Variable Neighborhood Search (RVNS) and the Tabu Search (TS) to solve the problem. The combination of multiple neighborhoods and tabu mechanism is used for their capacity to escape local optima while exploring the solution space. Furthermore, the intensification and diversification phases are also included to deliver optimized and diversified solutions. Extensive numerical experiments and comparisons with all the state-of-the-art algorithms show that the proposed method is highly competitive in terms of solution quality and computation time, providing new best solutions for a number of instances.
The aporia of refugee rights in a time of crises: the role of brokers in accessing refugee protection in transit and at the border
Authors: Riva Sara , Hoffstaedter Gerhard 
Published: January 2021

AbstractMany refugees fleeing from persecution across borders, find navigating the refugee registration system extremely complicated. In many border spaces, destination or transit countries, the difficult registration processes and the lack of support services requires the intervention and support of many non-state actors. Over the past decades, neoliberal policies have increasingly relegated public responsibilities to the private sphere. In this vein, a range of organisations have been working with refugees to assist them access to their legal status. This paper seeks to critically examine on-the-ground practices of these individuals, international and local non-profit organisations—or brokers—in Malaysia and the United States of America. Using ethnographic fieldwork data from these two very disparate fieldsites—one a signatory of the Protocol to the Convention, the other a non-signatory country—we document shared difficulties, frustrations, opportunities and specific obstacles, strategies and tactics refugees and organisations deploy. Building on Hannah Arendt’s insights of an internal contradiction in the human rights framework, we point to a new aporia: Whilst there now exist international instruments to protect refugees, access to this framework and its protections is becoming ever more challenging. This means that those seeking asylum need the assistance and mediation of third-party organisations in order to access their rights. The struggle for recognition and protection thus is no longer about achieving universal rights, but rather on how vulnerable populations can access them.
Dynamics of dormancy regulation in ‘Sonata’ strawberry and its relation to flowering and runnering
Authors: Sønsteby Anita , Heide Ola M. 
Published: January 2021

Abstract
Background
Dormancy regulation in strawberry is a dynamic process that is causally interrelated with regulation of flowering. Interference between the two processes is therefore possible.

Methods
We studied dormancy control and its relation to flowering and runner formation in ‘Sonata’ strawberry under daylight phytotron conditions. Growth and flowering were observed in plants pretreated for 5 or 10 weeks at 10-h SD and 18-h LD at 6 and 18 ℃ and subsequently forced in a greenhouse in LD at 20 ℃ with and without previous chilling for 6 weeks at 2 ℃ in darkness.

Results
SD induced constrained leaf and inflorescence growth at both 6 and 18 ℃, while the typical strawberry semi-dormant condition was attained only by exposure to SD at 18 ℃ for 10 weeks, which also completely blocked runner formation. The constrained leaf and inflorescence growth observed in plants grown in SD at 18 ℃ were partially reversed by 6 weeks of chilling and gradually overcome in successively emerging leaves. While plants grown in LD at 18 ℃ for 10 weeks remained vegetative under subsequent forcing, they unexpectedly initiated flowers when subjected to chilling in darkness for 6 weeks before the forcing.

Conclusions
SD exposure at 18 ℃ constrained leaf and inflorescence growth in ‘Sonata’ strawberry, and when applied for 10 weeks, it induced the persistent semi-dormant state that is typical for strawberry. Transient growth constraints were also induced at 6 ℃ in both SD and LD, while the semi-dormant state was only attained by SD at the higher temperature. Flowering in complete darkness, which is known in both SD and LD plants, did also take place in ‘Sonata’ strawberry in response to chilling in the dark at 2 ℃ for 6 weeks. While the potential impact of the phenomenon seems limited for regulation of flowering in strawberry, we conclude that chilling in the dark at near-freezing temperature may substantially enhance flowering in marginally induced strawberry plants.