bluuebunny/crossref_metadata_2025_split huggingface dataset:
6-lncRNA Assessment Model for Monitoring and Prognosis of HER2-Positive Breast Cancer: Based on Transcriptome Data
Authors: Zhang Xiaoming , Zhang Haiyan , Li Jie , Ma Xiaoran , He Zhengguo , Liu Cun , Gao Chundi , Li Huayao , Wang Xue , Wu Jibiao 
Published: April 2021

Background: In view of the high malignancy and poor prognosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer, we analyzed the RNA expression profiles of HER2-positive breast cancer samples to identify the new prognostic biomarkers.Methods: The linear fitting method was used to identify the differentially expressed RNAs from the HER2-positive breast cancer RNA expression profiles in the Cancer Genome Atlas (TCGA). Then, a series of methods including univariate Cox, Kaplan-Meier, and random forests, were used to identify the core long non-coding RNAs (lncRNAs) with stable prognostic value for HER2-positive breast cancer. A clinical feature analysis was performed, and a competing endogenous RNA network was constructed to explore the role of these core lncRNAs in HER2-positive breast cancer. In addition, a functional analysis of differentially expressed messenger RNAs in HER-2 positive breast cancer also provided us with some enlightening insights.Results: The high expression of four core lncRNAs (AC010595.1, AC046168.1, AC069277.1, and AP000904.1) was associated with worse overall survival, while the low expression of LINC00528 and MIR762HG was associated with worse overall survival. The 6-lncRNA model has an especially good predictive power for overall survival (p &lt; 0.0001) and 3-year survival (the area under the curve = 0.980) in HER2-positive breast cancer patients.Conclusion: This study provides a new efficient prognostic model and biomarkers of HER2-positive breast cancer. Meanwhile, it also provides a new perspective for elucidating the molecular mechanisms underlying HER2-positive breast cancer.
MASTER CLASS APPLICATION OF A COMPLEX OF APPROPRIATE PHARMACEUTICAL PRACTICES IN THE PROFESSIONAL TRAINING OF FUTURE MASTERS OF PHARMACY
Authors: VOSKOBOYNIKOVA G. , DOVZHUK V. , KONOVALOVA L. 
Published: April 2021

The article reveals the theoretical justification and methodological principles of designing a master class on the application of a set of good pharmaceutical practices in the training of future masters of pharmacy in higher education. It is determined that the practical implementation of the theoretically grounded principles of promoting the development of higher pharmaceutical education and the formation of professional competence of future masters of pharmacy in Ukraine based on the results of systematic analysis in the context of European integration of educational processes. the process of training future masters of pharmacy at universities in Central and Eastern Europe and in Ukraine. The design of integrated implementation in the educational process of professional training of future masters in the specialty 226 - Pharmacy, the use of interactive method and case-studi technology to assess the quality of the master class.
To provide pharmaceutical care based on evidence-based medicine and pharmacy on the basis of GPP implementation, it is necessary to comprehensively apply the methods of pharmacoeconomic analysis. An algorithm for the phased implementation of pharmacoeconomic analysis based on the integrated application of methods has been developed.
It is established that the Guidelines on Good Practices in Pharmacy in Regulated Markets are used at all stages of the circulation of medicines. At the stage of drug development, their safety and dose-dependence of efficacy on the basis of integrated implementation of GMP and GLP are studied.
At the stage of substantiation of the design of research in the process of clinical trials of therapeutic efficacy and safety, the regulatory document is a guideline with GLP.
To assess the quality of the proposed solution of situational problems using the interactive method and case-study technology, the software package "Case of professional readiness of masters of pharmacy to implement professional competencies of pharmacoeconomic justification of rational pharmacotherapy and support of pharmaceutical care."
PROCEDURAL COMPONENT OF READYNESS OF FUTURE TEACHERS OF MUSIC ART FOR CULTURAL AND EDUCATIONAL WORK IN EXTRACURRICULAR INSTITUTIONS
Authors: SOKOLOV D. 
Published: April 2021

The article, based on the analysis of theoretical literature, characterizes the procedural component of the readiness of future music teachers for cultural and educational work in out-of-school education institutions. It was found that the procedural component of the readiness of future music teachers for cultural and educational work in out-of-school education reflects the system of professional performing, artistic and creative skills that students need to carry out effective professional activities, as well as the ability to organize and implement future professional activity of cultural and educational work in the cultural and educational environment of the out-of-school education institution.
This system contains the following skills and abilities: didactic-methodical, organizational-managerial, musical-performing, research-design and information-educational.
PROJECT ACTIVITIES OF STUDENTS AND CRITERIA FOR EVALUATING RESULTS
Authors: TIMCHENKO G. , NEUSTROIEVA G. , PONOMARENKO N. 
Published: April 2021

The article discusses the issues of organizing students' project work as some modern approach that allows integrating theoretical knowledge and practical skills required for working in modern conditions. Being one of the forms of organizing the educational process, the project activity contributes to improving the quality of education, democratization of the communication style between teachers and students. The purpose of the project activity is to create conditions for the formation of research skills of the students, the development of their creativity and logical thinking. In the presented work practical recommendations for the teachers who want to use projects in their courses are provided.
A system of criteria according to which the student project will be evaluated has been developed. Criteria can be used as instructions that show what needs to be done to achieve the best results. The project evaluation is carried out not only at the stage of presentation and defense of the project, but also at the intermediate stages of its implementation.
SYSTEMIC PROCESSING OF COMPLEX SENTENCES IN MIDDLE SCHOOL (EXPERIMENTAL METHODOLOGY)
Authors: SHCHUPKO S. 
Published: April 2021

The article is devoted to the experimental method of studying various types of complex sentences. An integrative role of the syntax of complex sentences is noted. The article clarifies that the tasks faced by the teacher and the students during the systematic elaboration of complex sentences are complex and therefore there are considerable difficulties in their study. For example, when working out general information on complex sentences, we use various types of work on the development of coherent speech: the selection of conjunctions or connecting words, the replacement of certain means of communication by other, synonymous, the formation of a complex sentence of two simple, the division of complex sentences into simple, change the location of parts, etc.
However, all these types of exercises are conducted, in the majority of cases, orally, entirely subject to systematic study of theoretical material, since the main task of the first lessons is the formation of concepts that students will operate by analyzing individual types of complex sentences with one or more subcontractors.
Estimating pesticides in public drinking water at the household level in Denmark
Authors: Voutchkova Denitza D. , Schullehner Jörg , Skaarup Carina , Wodschow Kirstine , Ersbøll Annette Kjær , Hansen Birgitte 
Published: April 2021

Pesticide pollution has raised public concern in Denmark due to potential negative health impacts and frequent findings of new substances after a recent expansion of the groundwater monitoring programme. Danish drinking water comes entirely from groundwater. Both the raw groundwater and the treated drinking water are regularly monitored, and the chemical analyses are reported to a publicly available national database (Jupiter). Based on these data, in this study we (1) provide a status of pesticide content in drinking water supplied by public waterworks in Denmark and (2) assess the proportion of Danish households exposed to pesticides from drinking water. ‘Pesticides’ here refers also to their metabolites, degradation and reaction products. The cleaned dataset represents 3004 public waterworks distributed throughout the country and includes 39 798 samples of treated drinking water analysed for 449 pesticides (971 723 analyses total) for the period 2002–2019. Of all these chemical analyses, 0.5% (n = 4925) contained a quantified pesticide (>0.03 μg/l). Pesticides were found at least once in the treated drinking water at 29% of all sampled public waterworks for the period 2002–2019 and at 21% of the waterworks for the recent period 2015–2019. We estimate that 56% of all Danish households were potentially exposed at least once to pesticides in drinking water at concentrations of 0.03–4.00 μg/l between 2002 and 2019. However, in 2015–2019, the proportion of the Danish households exposed to pesticides (0.03–4.00 μg/l) was 41%. The proportion of Danish households potentially exposed at least once to pesticides above the maximum allowed concentration (0.1 μg/l) according to the EU Drinking Water Directive (and the Danish drinking water standard) was 19% for 2002–2019 and 11% for 2015–2019. However, the maximum concentrations were lower than the World Health Organization’s compound-specific guidelines. Lastly, we explore data complexity and discuss the limitations imposed by data heterogeneity to facilitate future epidemiological studies.
Passion to Profession: A review of Passion fruit Processing
Authors: Biswas Sristhi , Mishra Ritesh , Bist Ankur Singh 
Published: April 2021

Passion fruit (Passiflora edulis) is a nutritious tropical fruit belongs to the family Passifloraceae. The purple passion fruit is local from southern Brazil through Paraguay to northern Argentina. India, for a long time, has appreciated a moderate collect of purple passion fruit in the Nilgiris in the south and in various parts of northern India. The Passion fruit has good amount of antioxidants, flavanoids, anti- inflammatory, anti- bacterial, anti- fungal and anti- ageing properties. This fruit has huge economical importance as all the parts of this fruit (seed, peel, flower, pulp) are rich in medicinal and therapeutic properties. The fruit is a fantastic wellspring of dietary fiber, nutrient, Vitamin C and Vitamin A. Being a decent laxative, it likewise secures the colon mucosa by diminishing openness time to harmful substances in the colon and clearing off the malignant growth causing poisonous substances from the colon. Passion fruit has several medical advantages and hence require diverse processing and preservation methods. Here we are going to review portion of these methods.
PENGETAHUAN SERTA PERILAKU KESEHATAN GIGI DAN MULUT DENGAN PERIODONTITIS
Authors: Susanti Elita , Anang Anang , Rismayani Lina 
Published: April 2021

Latar belakang: Periodontitis merupakan peradangan yang mengenai jaringan pendukung gigi, disebabkan oleh mikroorganisme dan dapat menyebabkan kerusakan yang progresif pada ligamen periodontal, tulang alveolar dan disertai dengan pembentukan poket. Pengetahuan dan perilaku merupakan salah satu faktor yang mempengaruhi kesehatan gigi dan mulut. Tujuan penelitian: untuk mengetahui hubungan pengetahuan serta perilaku kesehatan gigi dan mulut dengan periodontitis pada pasien pengunjung poli gigi Puskesmas Kasomalang Kabupaten Subang. Metode: merupakan penelitian observasional analitik dengan rancangan cross sectional, menggunakan data sekunder melalui observasi rekam medik. Subjek penelitian berjumlah 57 orang dengan kriteria meliputi pasien baru dan pasien lama yang terdiagnosis periodontitis, berjenis kelamin laki-laki dan perempuan, usia 18 â€“ 65 tahun, serta mempunyai nomor telpon yang bisa dihubungi. Pengambilan sampel menggunakan teknik purposive sampling. Penelitian dilakukan dengan memberikan kuesioner tertutup menggunakan skala guttman dengan jenis soal dis-kontinum. Kuesioner telah diuji validitas (koefisien korelasi â‰¥ 0,361) dan uji reliabilitas (cronbachâ€™s alpha >0,940). Hasil penelitian: Responden memiliki tingkat pengetahuan baik (14,1%), cukup (59,6%), dan kurang (26,3%). Responden memiliki perilaku baik (31,6%) dan kurang baik (68,4%). Hasil analisis korelasi gamma antara pengetahuan kesehatan gigi dan mulut dengan periodontitis menunjukkan nilai p=0.021 (p<0.05) dan nilai r=0,632 positif dan searah. Hasil analisis korelasi gamma antara perilaku kesehatan gigi dan mulut dengan periodontitis menunjukkan nilai p=0.001 (p<0.05) dan nilai r=0,846 positif dan searah. Kesimpulan: terdapat hubungan yang bermakna dan signifikan antara pengetahuan kesehatan gigi dan mulut dengan periodontitis (kekuatan hubungan tergolong kuat). Terdapat hubungan yang bermakna dan signifikan antara perilaku kesehatan gigi dan mulut dengan periodontitis (kekuatan hubungan tergolong sangat kuat).
Kata kunci : Pengetahuan, Perilaku, Kesehatan Gigi dan Mulut, Periodontitis
Diagnostic Accuracy of Pleural Fluid Adenosine Deaminase Level Test in Tuberculous Pleural Effusion
Authors: Rosfadilla Puspa , Widirahardjo Widirahardjo , Syarani Fajrinur , Mutiara Erna 
Published: April 2021

Background: Tuberculous pleural effusion is a paucibacillary manifestation of tuberculosis, so isolation of Mycobacterium tuberculosis is difficult, biomarkers being an alternative for diagnosis. Adenosine deaminase has the potential to optimize the diagnostic approach of tuberculous pleural effusion.
Methods: This study is a diagnostic test observational (cross-sectional), which included 35 inpatient samples that meet inclusion and exclusion criteria from H. Adam Malik Medan General Hospital. Research began on February 1st until July 31st 2016 to examine 10 cc of pleural fluid specimens for the levels of Adenosine deaminase.
Results: There are significant differences in the levels of adenosine deaminase from tuberculous and non-tuberculous pleural effusion (P=0.001). In the cut-off point 36.55 IU/L, level of sensitivity 95.8%, specificity 90.99%, positive predictive value 95.8%, negative predictive value 90.99%, and accuracy 94.2% of pleural fluid adenosine deaminase level test in tuberculous pleural effusion.
Conclusion: Adenosine deaminase pleural fluid can be a diagnostic modality that is easy, fast, relatively affordable and applicable in the diagnosis of tuberculous pleural effusion. (J Respir Indo. 2017; 37(4): 278-82)
Clinical and Demographic Characteristics Differences between M. tuberculosis and M. bovis Infection in Bronchoalveolar Lavage Pulmonary TB Patients, Indonesia
Authors: Yanti Budi , Soetjipto Soetjipto , Mertaniasih Ni Made , Amin Muhammad 
Published: April 2021

Background: Some species of the Mycobacterium tuberculosis complex (MTBC) which can cause tuberculosis, particularly M. tuberculosis and M. bovis, may have different virulence property and therefore associated with various clinical severity in tuberculosis (TB) patients. The aim of this study was to determine the differences in clinical and demographic characteristics between M. tuberculosis and M. bovis infection among Indonesian TB patients.
Methods: Thirty-one new and active TB patients were confirmed to have acid fast bacilli (AFB) sputum positive and/or Xpert MTB/RIF positive for M. tuberculosis from Dr. Soewandhie Hospital, Surabaya, Indonesia. Interviews were conducted to record the clinical and demographics required. The MTBC were isolated from bronchoalveolar lavage fluid (BALF) and determined by primer-specific PCR targeting TbD1 and RD9 region gene. The degree of lung tissue damage was classified using NICE Scoring System.
Results: The MTBC were detected in all patients on whom 19 and 12 isolates were classified as M. tuberculosis and M. bovis respectively. There was a different on 74.2% of productive age subjects (21-50 years) with M. tuberculosis infection (P
The Relationship Between Level of Transforming Growth Factor - β with Pulmonary Fibrosis in Post Pulmonary Tuberculosis in Medan
Authors: Christine Tamara , Tarigan Amira Permatasari , Nainggolan Nuryunita , Zaluchu Fotarisman 
Published: April 2021

Background: Untreated or undertreated, pulmonary tuberculosis could cause severe complications until death. After treatment, residual lesions might occur. The presence of residual lesions is varied, including: fibrosis, cavity, bronchiectasis and calcification. Transforming growth factor-β (TGF-β) is a cytokine associated with lung inflammation, which plays a role in lung fibrosis. However, only a few studies have assessed the serum level of TGF-β in post-treatment tuberculosis patients. The main objective of this study was to determine the relationship between TGF-β levels and pulmonary fibrosis in patients with pulmonary tuberculosis.
Methods: Among 51 patients that had undergone anti-tuberculosis treatment were observed, consisting of 31 men, 20 women. Of all patients, there were 26 people with a smoking history, including 25 men and 1 woman. All patients had been recovered, confirmed by clinical state, laboratory and radiology examination. The ELISA test was performed to measure TGF-β level, while chest X-ray was used to evaluate for the occurence of pulmonary fibrosis.
Results: The mean level of TGF-β in patients with lesion (+) was 7628.02 pg/mL (SD: ±4928.38) while the mean level of TGF-β in patients with lesion (-) was 2315.11 pg/mL (SD: ±505.83). Statistical test showed a significant relationship between TGF-β level and fibrosis lesion (P
The Effect of Quercetin on Plasma Interleukin-5, Blood Eosinophil Absolute, %FEV1, and Clinical Improvement of Asthma Alergy Patient
Authors: Mayasari Hesti Nila , Suradi Suradi , Setijadi Ana Rima 
Published: April 2021

Backgrounds: Asthma is a chronic airway inflammation which is a manifestation of complex interactions between cells and moleculer mediators. The aims asthma management is to reach asthma in controlled state. Providing an additional therapy in these circumstances is necessary to control asthma. Quercetin as an adjunctive therapy in asthma therapy may improve clinical symptoms and lung function.
Methods: Experimental clinical trials of pretest of and postest design were conducted on 34 patient’s asthma at Dr. Moewardi Hospital Surakarta in 6 October–10 December 2018. Subject of treatment group (n= 17) was given quercetin 500 mg per day within 28 days, the control group (n=17) received only standar therapy asthma. Decreased airway inflammation was assessed based on the percentage of blood eosinophil and IL-5. Clinical improvement was assessed by ACT score while lung function used FEV1.
Results: Quercetin decreased the inflammatory airways in patients with asthma evidenced by significant decrease in plasma IL-5 of treatment groups but no significant differences between treatment and control group, the mean decrease of blood eosinophil in the treatment group was significant. Querectin improved lung function with decrease FEV1 of treatment groups but no significant differences between treatment and control group and there was a clinical improvement with significant ACT score enhancement in the treatment group.
Conclusion: The administration of quercetin significantly reduced inflammation based on decreased levels of eosinophils. There are improvement of lung function and clinical symptoms after quercetin. (J Respir Indo. 2020; 40(1): 16-23)
The Effect of Two-Mile Jogging Training on Lung Function Values in TNI Soldier Kodam I/Bukit Barisan
Authors: Hayati Rifda , Nainggolan Nuryunita , Tarigan Amira Permatasari , Eyanoer Putri Chairani 
Published: April 2021

Background: Military soldiers are army personnel who are required to have good physical endurance and optimal fitness, include. So, it's needed physical exercise, include to be able to improve lung function. One parameter that can reflect physical fitness are lung function and m VO2max. This study aims to determine whether there is a relationship between physical exercise in the form of 2-mile jogging with increased lung function and VO2max of military soldiers Kodam 1 Bukit Barisan
Methods: This research is an experimental study carried out in February-April 2019 against the TNI soldiers of the Bukit Barisan Military District 1. The research subjects were divided into two groups, group 1 who underwent regular 2-mile jogging exercises 3-5 times a week with a duration of 25 minutes for 2 months, and group 2 who underwent non-routine jogging exercises (less than 3 times a week). Lung function was assessed by spirometry.
Results: As many as 68 military soldiers were involved in this study which were divided into two groups, 38 people in the group 1 who routinely trained and 30 people in group 2 that did not routinely practice. Group 1 VEP1 values were higher than group 2 (p=0.03). No significant differences in terms of KVP, MVV and VO2max in both groups. Lung function of smokers were lower than non-smokers, but not statistically significant.
Conclusion: There were significant differences in VEP1 values between military soldiers who routinely and did not routinely undergo 2-mile jogging exercises.
Entre la vara y los indios: la sociedad de Charcas frente a parejas imposibles (1560-1580)
Authors: Presta Ana María 
Published: April 2021

Entre los primeros oidores de la Real Audiencia de Charcas, el faccionalismo, los regionalismos peninsulares y el nepotismo se revelaron tras el romance entre una viuda encomendera y un miembro del tribunal, quienes renunciaron a casarse para no perder sus más preciados bienes: los indios y la vara. Diez años más tarde, otro episodio similar reunió a otros protagonistas que optaron por un matrimonio que generó sanción y venganza por parte de las autoridades. Dos instituciones en las que descansaban el disciplinamiento sexual y la reproducción estamental, por un lado, y la administración de la justicia y el gobierno local y regional, por el otro, colisionaron con las ambiciones personales y del funcionariado. En ambas ocasiones, el supuesto respeto a la ley expresaba las más abyectas iniquidades y miserias humanas, amparadas en la norma y el temor a la transgresión.
El Cabildo de los Veinticuatro Electores del Alférez Real Inca de las ocho parroquias cusqueñas
Authors: Amado Gonzales Donato 
Published: April 2021

El presente artículo ofrece una visión general del Cabildo de los Veinticuatro Electores, entidad virreinal encargada de elegir al alférez real inca que debía participar en la fiesta anual en honra del Apóstol Santiago en la ciudad del Cusco. Esta institución estaba integrada por los descendientes de las panacas incaicas, vinculadas a parroquias de indios de la ciudad. El presente estudio nos informa sobre los orígenes de esta institución, la importancia que adquirió para determinar quién debía ser considerado digno del linaje incaico y el uso de sus símbolos, prerrogativas y privilegios. La investigación muestra también los mecanismos con los que la nobleza incaica otorgaba y recibía legitimación del sistema monárquico hispánico.
El discurso del indigenismo en Manuel González Prada y Luis E. Valcárcel
Authors: Gonzales Alvarado Osmar 
Published: April 2021

Este artículo presenta una perspectiva comparada de los discursos indigenistas en dos pensadores peruanos que tuvieron mucha influencia en el ambiente cultural peruano de fines del siglo XIX e inicios del XX: Manuel Manuel González Prada y Luis E. Valcárcel. El primero es representativo de un indigenismo desde una visión anarquista y el segundo representa un indigenismo de corte marxista. Ambas visiones con importantes para entender el fenómeno del indigenismo en el Perú.