bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification, documentation and utilization of wild green leafy vegetables from tribal region of Nashik District
Authors: SP Chavan , AS Jondhale 
Published: October 2021

Abstract
From many years ago the tribal peoples commonly used numbers of wild leafy vegetables all over the world. Peth and Surgana are well known tribal region from Nashik district. The tribal community from that region was partially or fully dependent on the wild green leafy vegetables to complete their nutritional need. In present study from selected tribal region of Nashik district, a total 61 traditionally used wild green leafy vegetables was identified. Among 61 species, with respect to families Amaranthaceae, Fabaceae and Asteraceae were found to be largest family of wild leafy vegetables with 22 species. Presently because of modernization in agricultural practices, negligence of uncultivated plants, less awareness, illiteracy and sudden environmental changes the naturally grown wild leafy vegetables source was limited. So present study was focused on the identification and conservation of these species for future need.
Urban Seismic Risk Analysis Using Empirical Fragility Curves for Kerend-e-Gharb After Mw 7.3, 2017 Iran Earthquake
Authors: Biglari Mahnoosh , Formisano Antonio 
Published: October 2021

Abstract
This study provides the seismic risk map of the small mountain city of Kerend-e-gharb. This innovative study evaluates the existing methods and formulations with the effects of a devastating earthquake using empirical fragility curves. A seismic vulnerability map is developed at the urban block-scale at a Geographic Information System for a variety of steel, reinforced concrete, confined masonry, unreinforced masonry, and adobe residential buildings. The estimated seismic damages are validated by comparing them with the surveyed building damages in the Sarpol-e-zahab earthquake. Moreover, the damages to the population, including the probability of homelessness, death, severe injuries that need immediate hospital treatment, moderate injuries that require hospital treatment, and light injuries without hospitalization, are assessed. This research also investigated the economic losses and estimation of debris. Finally, the mean damage index map is presented. The mean damage index map is modified due to renovation and retrofitting at higher damage levels, and it is increased at moderate damage levels that have not been structurally improved. The results of this study can be used in seismic crisis management planning in natural hazards to achieve a sustainable city.
A simulation to identify the optimal area to survey in the early stage of invasion by Solenopsis invicta
Authors: Hisamoto Shumpei , Goka Koichi , Sakamoto Yoshiko 
Published: October 2021

Abstract
Efforts to eradicate invasive alien species commonly use simulations to calculate the cost-effectiveness of surveys. Although eradication of Solenopsis invicta in the early stages of an invasion is important, few simulations are available to calculate the cost-effectiveness of surveys when a single colony has been detected. In the case of S. invicta, it is difficult to determine from the status of the detected colony whether new queens have dispersed, so it is necessary to consider dispersal as a probabilistic event and calculate its probability. We therefore first constructed a mathematical model in which we used Bayesian statistics to estimate the probability of dispersal as a function of the results of the survey. This mathematical model revealed that the efficacy of the survey and the associated cost differed greatly between cases depending on whether dispersal was or was not confirmed. Next, we developed a simulation that incorporated this mathematical model to inform the determination of the survey area when a single colony had been detected. The simulation showed how ecological parameters and geographical information could be used to identify an efficacious survey area, even in heterogeneous landscapes such as international ports where invasions occur sporadically. Finally, we used this simulation to assess the efficacy of a survey in the case of an S. invicta outbreak at the Port of Tokyo, Japan. The results suggested that the survey covered a sufficiently wide area but that it could have been designed in a more efficacious manner.
Oral Versus Intravenous Antibiotics for Pediatric Osteoarticular Infection: When and to Whom?
Authors: Alcobendas Rosa , Nuñez Esmeralda , Martin Laura , Hernández María Belén , Saavedra-Lozano Jesús , Udaondo Clara , Murias Sara , Remesal Agustin , Calvo Cristina 
Published: October 2021

Abstract
Background

Osteoarticular infections are typically treated initially with intravenous antibiotics. The objective of this study was to evaluate whether an exclusive oral treatment in selected children may be appropriate.
Methods

The Spanish Network of Osteoarticular Infections is a nationwide multicenter registry comprising 37 hospitals in Spain. The registry prospectively includes clinical characteristics and outcome of children with OAI. One of the hospitals from RioPed offers oral treatment to children meeting certain criteria. Patients were classified into two groups. Group 1: management with initial intravenous antibiotic therapy. Group 2: patients exclusively treated with oral antibiotics. A comparison between the two groups was performed.
Results

We compared 893 children who initially received intravenous antibiotics (Group 1) with 64 children who received exclusively oral therapy (Group 2). Patients from Group 2 were younger (33.9 vs 20.3 months; p=0.001), had a lower percentage of Staphylococcus aureus (23.3% vs 3.1%, p <0.001), a higher proportion of Kingella kingae (12.1% vs 28.1%; p = 0.001), higher ESR/CRP ratio (1.4 IQR 0.6-3.6 vs 3.3 IQR 1.7-5.7, p <0.001) and showed lower rate of fever (63% vs 48.8%; p=0.024). Complications were not found in Group 2.
Conclusion

An exclusively oral administration could be a safe option in selected patients with OAI. Low-risk criteria are proposed: good general condition, no underlying disease, 6 months-3 years of age, appropriate oral tolerance, CRP ≤80 mg/L, ESR/CRP ratio ≥ 0.67, no skin injury, no recent surgery, no cervical spondylodiscitis and no local complications at onset.
A Review on Potentials of Artificial Intelligence Approaches to Forecasting COVID-19 Spreading
Authors: Jamshidi Mohammad (Behdad) , Roshani Sobhan , Talla Jakub , Lalbakhsh Ali , Peroutka Zdeněk , Roshani Saeed , Sabet Asal , Dehghani Mojgan , Lotfi Saeedeh , Hadjilooei Farimah , Lalbakhsh Pedram 
Published: October 2021

Abstract

COVID-19 is by now one of the deadliest public health issues that as per the last announcement of the World Health Organization up to January 21, 2021, has infected more than 108,904,983 people and claimed more than 2,398,339 lives worldwide. Although different vaccines have proved and distributed one after another, several new mutated viruses have been detected, such as the new COVID-19 variant detected in the UK. Since new variants can spread so faster than the previous one and many other strains may come, it is necessary to focus on the effective methods that are able to predict the spreading trends quickly. Regarding the considerable progress in Artificial Intelligence (AI), utilizing AI-based techniques with a concentration on Deep Learning (DL) and Machine Learning (ML), which can forecast complex trends like epidemiological issues, are proposed to conquer the problems existing in statistical or conventional techniques. In this respect, the present paper reviews the recent peer-reviewed published articles and preprint reports about solutions that could efficiently address COVID-19 spread with a focus on the state-of-the-art and AI-based methods. The results revealed that methods under discussion in this paper have had significant potentials to predict epidemic diseases like COVID-19 as well as its mutations; however, there are still weaknesses and drawbacks that fall in the domain of future research and scientific endeavors.
Baited video, but not diver video, detects a greater contrast in the abundance of legal-size target species between no-take and fished zones
Authors: Haberstroh Anna Julia , McLean Dianne , Holmes Thomas H. , Langlois Tim 
Published: October 2021

Abstract
Inherent differences between baited remote video versus diver-operated video survey methodologies may influence their ability to detect effects of fishing. Here the ability of no-take zones (NTZs) to provide protection for legal-sized fish from targeted species within the Ningaloo Marine Park (NMP) was assessed using both baited remote underwater stereo-video (stereo-BRUV) and diver operated stereo-video (stereo-DOV). The relative abundance of legal-sized individuals of three recreationally targeted fish species, spangled emperor Lethrinus nebulosus, chinaman cod Epinephelus rivulatus and goldspotted trevally Carangoides fulvoguttatus, were examined using both methodologies inside and outside six NTZs across the NMP. Stereo-BRUVs found positive effects of protection on the relative abundance of legal-size C. fulvoguttatus and L. nebulosus in NTZs. Stereo-DOVs, however, did not detect any differences in relative abundances and sizes of these species between areas opened and closed to fishing. These contrasting results suggest that choice of sampling methodology can influence interpretations of the ability of NTZs to provide adequate levels of protection for target species. Thus it is suggested to further investigate the ability of stereo-BRUVs and stereo-DOVs to observe differences in the abundance of targeted species inside and outside of NTZs for the long-term monitoring of the NMP.
Reliability and validity of digital health metrics for assessing arm and hand sensorimotor impairments in persons with autosomal recessive spastic ataxia of Charlevoix-Saguenay
Authors: Kanzler Christoph M. , Lessard Isabelle , Gassert Roger , Brais Bernard , Gagnon Cynthia , Lambercy Olivier 
Published: October 2021

Abstract
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is the second most frequent recessive ataxia and commonly features reduced upper limb coordination. Sensitive outcome measures of upper limb coordination are essential to track disease progression and the effect of interventions. However, available clinical assessments are insufficient to capture behavioral variability and detailed aspects of motor control. While digital health metrics extracted from technology-aided assessments promise more fine-grained outcome measures, these have not been validated in ARSACS. Thus, the aim was to document the metrological properties of metrics from a technology-aided assessment of arm and hand function in ARSACS, and ensure that those can be used as insightful endpoints. We relied on the Virtual Peg Insertion Test (VPIT) and used a previously established core set of 10 digital health metrics describing upper limb movement and grip force patterns during a pick-and-place task. We evaluated reliability, measurement error, and learning effects in 23 participants with ARSACS performing three repeated assessment sessions. In addition, we documented concurrent validity in 57 participants with ARSACS performing one session. Eight metrics had excellent test-retest reliability (intra-class-correlation-coefficient 0.89±0.08), five low measurement error (smallest real difference 25.4±5.7), and none strong learning effects (systematic change η -0.11±2.5). Significant correlations (ρ 0.39±0.13) with clinical scales describing gross and fine dexterity and lower limb coordination were observed. This establishes eight digital health metrics as valid and robust endpoints for cross-sectional studies and five metrics as potentially sensitive endpoints for longitudinal studies in ARSACS, thereby promising novel insights into upper limb sensorimotor control.
Effect of Ellagic Acid, Cilostazol and Their Combination on Amikacin Induced Nephrotoxicity in Rats
Authors: Saeed Zeinab Mahmoud , Khattab Monira Ismail , Khorshid Nadia Esmat , Salem Amal Elsayed 
Published: October 2021

Abstract
Amikacin(AK) has the largest spectrum of aminoglycosides. However, its use is limited due to nephrotoxicity and ototoxicity. Ellagic acid (EA) is a plant phenolic structure. it has antioxidant, anticarcinogenic and antimutagenic properities. Cilostazol (CTZ) is a PDE Ш inhibitor, it is a potent vasodilator and antiplatelet drug. This study aimed to determine if EA and cilostazol have a protective effect against nephrotoxicity caused AK. Forty nine rats were divided into seven equal groups: control normal; AK 400mg/kg; EA 10 mg/kg; CTZ 10mg/kg; AK 400mg/kg plus EA 10mg/kg; AK 400mg/kg plus CTZ 10mg/kg; AK 400mg/kg plus EA 10mg/kg and CTZ 10mg/kg. For seven days, Drugs were given orally one hour before intramuscular injection of AK. After twenty-four hours from the last dosage, samples of blood were obtained to determine blood urea nitrogen (BUN) and creatinine levels in serum, kidneys were extracted and longitudinally divided into two parts, part for measuring the following parameters: malondialdehyde (MDA), catalase (CAT), reduced glutathione (GSH), interleukin 6 (IL6), superoxide dismutase (SOD), tumor necrosis factor-alpha (TNFα), nuclear factor kappa B (NFκB) and Bcl-2 associated x protein (Bax), the other part was placed in formaldehyde solution and examined under light microscopy for routine histopathologic examination. The results of the present study proved that EA, CTZ and their combination protected rats against AK - induced nephrotoxicity; This effect might be a result of the antioxidant, anti-inflammatory and anti-apoptotic properties of these compounds.
Groundwater Quality Assessment Using Water Quality Index and Multivariate Statistical Analysis Case Study: East Matrouh, Northwestern Coast, Egypt.
Authors: ali rasha , Zaghlool Ehab , Isawi Heba , Soliman Elsayed , Khalil Mostafa , El-Aassar Abdelhameed , Said Moustafa 
Published: October 2021

Abstract
The groundwater quality deterioration is a global phenomenon due to the effect of contaminated surface water. This study covers the investigation of groundwater quality using the contamination indices, statistical analysis, and hydrochemical facies. Thirty-one water samples that representing the water resources in the study area were collected and analyzed for chemical compositions. There are two aquifers; Pleistocene and Miocene. From the obtained data, the electric conductivity (EC) values ranged from 8520 to 19410 μS/cm in Pleistocene aquifer. While in Miocene aquifer, it ranged from 4290 to 7920 μS/cm. The wide variation is due to interaction with aquifer rocks. The hydrochemical facies evolution diagram (HFE-D) indicated that the majority of samples belong to an intrusion phase; the Na-Cl facies represents the state of the aquifer and the remaining sample is scattered in the field of freshening. The dominance of average cations is about Na+ > Mg2+ > Ca2+ > K+, where the anion dominance average is in the imperative of Cl− > SO42− > HCO3-. Multivariate statistical techniques, such as cluster analysis (CA) and factor analysis (FA) showed contamination with heavy metal and fecal due to the influence of the sewage treatment plant. The spatial distribution of heavy metal pollution index (HPI), Ecological risk index (ERI) and pollution index of groundwater (PIG), in the southeastern portion of the research, revealed high values near the center and particularly in the northwest portion of the study region. It demonstrated that water in the northeast of the study area is likely to be influenced by heavy metal leaching from the water treatment plant.
miR-500a-3p/CDK6 Axis Suppresses Aerobic Glycolysis in Colorectal Cancer
Authors: Liu Yu , Tang wentao , Ren Li , Liu Tianyu , Meng Yang , Wei Ye , Chen Yijiao , Ji Meiling , Chen Guosong , Chang Wenju , Xu Jianmin 
Published: October 2021

Abstract
Backgrounds

Colorectal cancer (CRC) is one of the cancers with the highest mortality rate and understanding the mechanism behind its progression is the key to improve patients’ prognosis. The role of miR-500a-3p has been demonstrated to be involved in the progression of several human cancers but its role in CRC is unclear. The aim of this study was to disclose the function of miR-500a-3p in CRC progression.
Methods

The expression of miR-500a-3p and Cyclin-dependent kinases 6 (CDK6) in 134 CRC tissues were tested respectively. The effects on cell proliferation by miR-500a-3p were explored in vitro and in vivo. The glycolysis of CRC cells was determined by Mass Spectrometry and Seahorse XF 96 Extracellular Flux Analyzer. Dual-luciferase reporter assay were performed to validate the relationship between miR-500a-3p and CDK6.
Results

miR-500a-3p was abnormally down-regulated in CRC tissues and cell lines and was negatively associated with malignancies and worse prognosis. miR-500a-3p mimics impeded CRC cells proliferation in vitro and in vivo. miR-500a-3p inhibited glucose consumption, lactate and ATP production, down-regulated the expression of hexokinase2 (HK2). Bioinformatics database prediction combined with western blot and luciferase assay confirmed that CDK6 is the direct target of miR-500a-3p. CDK6 overexpression was able to rescue the inhibitory function of miR-500a-3p on the proliferation and glycolysis in CRC cells.
Conclusions

The results of this study reveal a potential tumor suppressor role of miR-500a-3p by inhibiting proliferation and aerobic glycolysis through targeting CDK6 in CRC, which may provide new insights into novel prognostic biomarker and therapeutic targets for CRC.
Analyzing asymmetric effects of cryptocurrency demand on environmental sustainability
Authors: Erdogan Sinan , Ahmed Maruf Yakubu , Sarkodie Samuel Asumadu 
Published: October 2021

Abstract
When Bitcoin (BTC), the first pioneering cryptocurrency was released in 2009, it was considered as an apolitical currency. Besides, the possible effect of BTC and other cryptocurrencies on either financial markets or transactions has been widely discussed. However, the environmental effects of cryptocurrency demand have been ignored. Here, this study examines the nexus between cryptocurrencies and environmental degradation by employing standard and asymmetric causality methods. The Toda-Yamamoto and bootstrap-augmented Toda-Yamamoto test results reveal Bitcoin and Ethereum (ETH) excluding Ripple (XRP) have causal effects on environmental degradation. The Fourier-augmented Toda-Yamamoto test results show causal effects running from Bitcoin and Ripple to environmental degradation, whereas no causal effect runs from Ethereum to environmental degradation. The asymmetric causality shows causal effects from the positive shock of Bitcoin demand, negative shocks of Ripple and Ethereum demands to positive shocks of environmental degradation. Further discussions and policy implications are provided in the relevant sections of this study.
MiR-155-5p modulates inflammatory phenotype of activated oral lichen-planus-associated-fibroblasts by targeting SOCS1
Authors: Cheng Juehua , Zhang Yuyao , Liu Kefan , Wang Yanting , Xu Juanyong , Fan Yuan 
Published: October 2021

Abstract
Micro (MiR)-155-5p plays a vital role in inflammation and immune responses, but the function in oral lichen planus (OLP) remains unclear. Recent research has revealed that OLP associated-fibroblasts (OLP AFs) contribute to the inflammatory process with activated phenotype. This study was carried out to assess the role of miR-155-5p in the pro-inflammatory process of activated OLP AFs. Normal mucosal fibroblasts (NFs) and OLP AFs were isolated from oral mucosa of healthy controls and OLP patients respectively. We detected the expression of miR-155-5p and FAP-α in NFs and OLP AFs by real-time RT-PCR and calculated their correlation. Enzyme-linked immunosorbent assay was used to detect cytokine production. Immunohistochemistry and western blotting assay were used to detect suppressor of cytokine signaling 1 (SOCS1) expression. Dual-luciferase reporter assay was conducted to explore the interaction between miR-155-5p and SOCS1. MiR-155-5p and FAP-α were significantly increased in OLP AFs, and positively correlated. The expression of SOCS1 is decreased in the epithelial layer of OLP tissues and OLP AFs. Overexpression of miR-155-5p augmented interleukin-6 (IL-6) and interleukin-8 (IL-8) release. The knockdown of miR-155-5p in OLP AFs decreased IL-6 and IL-8 release. Furthermore, miR-155-5p inhibits SOCS1 expression by directly targeting its 3′-UTR in NFs and OLP AFs. SOCS1 silencing augmented IL-6 and IL-8 production in NFs. Here, we suggest that miR-155-5p regulates the secretion of IL-6 and IL-8 by downregulating the expression of SOCS1 in activated OLP AFs. Our results provide novel insights into the pathogenesis of OLP and a new target for OLP future therapy.
Hepatobiliary continuum: non-alcoholic fatty liver disease, cholelithiasis ... what else?
Authors: Bueverov A. O. 
Published: October 2021

The relationship between metabolic non-alcoholic fatty liver disease (NAFLD) and gallstone disease (GSD) is complex and seemingly interrelated. There is no doubt that there is an increased risk of cholelithiasis in patients with NAFLD, which is primarily associated with general pathogenetic mechanisms. These include central and peripheral insulin resistance, changes in the expression of transcription factors (hepatic X-receptor, farnesoid X-receptor (FXR) and membrane bile acid receptors (TGR5)). At the same time, the effect of gallstone disease on the course of NAFLD is assumed, although the pathogenetic factors of this association are still insufficient. There are accumulating data on an increased risk of other pathologies of the biliary tract in patients with NAFLD, in particular, of gallbladder polyps and tumors of the biliary tract. Recently there have been convincing data on the role of cholecystectomy in the progression of NAFLD, which may be due to disruption of endocrine balance and signaling function of bile acids, as well as the development of bacterial overgrowth in the small intestine. General therapeutic approaches to the treatment of interrelated hepatobiliary pathology may include new generation insulinsensitizers, FXR agonists, and ursodeoxycholic acid. The link between NAFLD and the pathology of the biliary tract is complex and multifaceted, and its further study opens up prospects for the development of new methods of treatment.