bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk assessment of sepsis through measurement of proAVP (copeptin): a secondary analysis of the TRIAGE study
Authors: Kloter Milena , Gregoriano Claudia , Haag Ellen , Kutz Alexander , Mueller Beat , Schuetz Philipp 
Published: July 2021

Objective
Systemic infections and sepsis lead to strong activation of the vasopressin system, which is pivotal for stimulation of the endocrine stress response and, in addition, has vasoconstrictive and immunomodulatory effects. Our aim was to assess the significance of the vasopressor system through measurement of C-terminal proAVP (copeptin) regarding mortality prediction in a large prospective cohort of patients with systemic infection.

Design and methods
This secondary analysis of the observational cohort TRIAGE study included consecutive, adult, medical patients with an initial diagnosis of infection seeking emergency department care. We used multivariable regression analysis to assess associations of copeptin levels in addition to the Sequential Organ Failure Assessment (SOFA) score with 30-day mortality. Discrimination was assessed by calculation of the area under the curve (AUC).

Results
Overall, 45 of 609 (7.4%) patients with infection died within 30 days. Non-survivors had a marked upregulation of the vasopressin system with a more than four-fold increase in admission copeptin levels compared to non-survivors (199.9 ± 204.7 vs 46.6 ± 77.2 pmol/L). In a statistical model, copeptin was significantly associated with mortality (adjusted odds ratio of 1.04, 95% CI 1.01 to 1.07, P = 0.002). Regarding discrimination, copeptin alone showed an AUC of 0.82, while adding copeptin to the SOFA score significantly improved its prognostic ability (AUC 0.83 vs 0.86, P = 0.027).

Conclusion
Activation of the vasopressin system mirrored by an increase in copeptin levels provided significant information regarding mortality risk and improved the SOFA score for prediction of sepsis mortality.
Práticas avaliativas nos cursos de pedagogia: concepções, modelos e planejamento
Authors: Da Silva Neta Maria de Lourdes , Junior Antonio Germano Magalhães , Carneiro dos Santos Maria Terla Silva 
Published: July 2021

As práticas avaliativas estão inseridas no trabalho docente em todos os níveis e modalidades da educação podendo auxiliar no direcionamento dos processos de formação, na emissão do juízo de valor e na tomada de decisão por gestores e professores. O objeto da pesquisa aportou-se nas práticas de avaliação disseminadas nos cursos de licenciatura em Pedagogia de uma IES pública cearense. Objetivamos compreender as práticas avaliativas dos docentes. A metodologia de cunho qualitativo recorreu à postura cartográfica utilizando técnicas de coleta de dados bibliográfica, documental e entrevistas por pautas com professores. As práticas se constituíram pelas concepções de medida, instrumento e controle. Evidenciamos que as práticas avaliativas no ensino-aprendizagem pautadas no planejamento e nos modelos avaliativos no âmbito da educação superior nos levaram a constatar a relevância e necessidade de aquisição do conhecimento em avaliação pelos docentes, requerendo articulações com as concepções de currículo, uma vez que nelas se expressam, sobretudo as escolhas dos conteúdos, as definições emanadas do planejamento, a adoção dos modelos, a sistematização dos instrumentos e critérios com escopo no trabalho do professor e na aprendizagem dos discentes.
Changes in gambling behaviour and related problems in clients seeking help in outpatient addiction care: Results from a 36-month follow-up study in Bavaria
Authors: Bickl Andreas M. , Schwarzkopf Larissa , Loy Johanna K. , Grüne Bettina , Braun-Michl Barbara , Sleczka Pawel , Örnberg Jenny Cisneros , Kraus Ludwig 
Published: July 2021

AbstractBackground and aimEvidence on the course of gambling disorder (GD) in clients seeking help from outpatient addiction care facilities is sparse. To close this knowledge gap, this longitudinal one-armed cohort study portrays the development of GD in help-seeking clients over a 3-year timeframe.MethodsWe investigated changes in severity of GD as well as in gambling frequency and intensity in 145 gamblers in outpatient treatment in Bavaria using generalized estimation equations (GEEs). To investigate potentially different trajectories between study participants with and without migration background (MB), additional analyses were applied with time*migration interaction. All analyses were adjusted for age, gender, education, electronic gambling machine (EGM) gambling, MB, GD, related help sought before and treatment status.ResultsWithin the entire study population, improvements in severity of GD (reduction of 39.2%), gambling intensity (reduction of 75.6%) and gambling frequency (reduction of 77.0%) were observed between baseline and 36 months of follow-up. The declines were most pronounced between baseline and follow-up 1 and stabilized thereafter. Participants with MB improved consistently less than participants without MB.Discussion and conclusionOur study suggests that severity of GD and gambling patterns improve in the context of outpatient treatment. The beneficial results furthermore persist for 36 months after treatment termination. As clients with MB seem to profit less than clients without MB, improvements in outpatient gambling services to the specific needs of this clientele are required.
Creatividad y Enfoques de Aprendizaje en Estudiantes Universitarios
Authors: Freiberg Hoffmann Agustín , S Vigh Carlos , Fernández-Liporace Mercedes 
Published: July 2021

Introducción: Mejorar el aprendizaje de los estudiantes y adaptarlo a las demandas del mercado laboral actual es un tema de gran interés planteado por distintos organismos internacionales. Se busca así que los alumnos alcancen un aprendizaje profundo de los contenidos académicos y que a su vez desarrollen su capacidad creativa para la resolución de problemas.
Objetivo: Analizar los enfoques de aprendizaje –Profundo y Superficial– y la creatividad –proceso creativo y personalidad creativa– en estudiantes universitarios según variables sociodemográficas y académicas.
Método: Se empleó un diseño no experimental y transversal. Se respondió a un objetivo de diferencias entre grupos y a otro explicativo. Participaron 301 estudiantes universitarios de Psicología (51%) e Ingeniería (49%).
Resultados: Se registraron diferencias significativas en los enfoques profundo y superficial: el primero a favor de las mujeres, y el segundo favorable a los varones. En relación con la creatividad, se observó una diferencia significativa en la personalidad creativa a favor de los varones, y del proceso creativo a favor de los estudiantes de Psicología. Por otra parte, el rendimiento académico fue explicado negativamente por el enfoque superficial (β=-.276) y positivamente por el proceso creativo (β=.185).
Conclusiones: Para mejorar el rendimiento académico se necesita aplicar estrategias de enseñanza y evaluación que desestimulen el aprendizaje superficial y promuevan el proceso creativo en los estudiantes. Los cambios en las prácticas educativas deberán, además, enfocarse en mejorar el aprendizaje profundo y la creatividad para ajustar el perfil profesional de habilidades de los egresados al requerido actualmente por el ámbito laboral
Complications of robot-assisted and laparoscopic partial nephrectomy
Authors: Rakul S. A. , Pozdnyakov K. V. , Eloev R. A. 
Published: July 2021

Objective: to analyze complications after laparoscopic and robotic-assisted partial nephrectomy.Materials and methods. In our study was included 246 cases. Intra- and postoperative complications were studied after nephron-sparring surgery. The laparoscopic approach was used in 68 (27.3 %) cases, the robot-assisted - in 178 (71.5 %) cases. Intraoperative complications were assessed according to the Rosenthal classification, postoperative complications - according to the Clavien-Dindo classification.Results. The overall incidence of intraoperative complications was 12.6 %. The most frequent intraoperative complication was bleeding that did not require blood transfusion (grade I) - 5.69 % (laparoscopic approach - in 3 (4.41 %) cases, robot-assisted approach - in 11 (6,18 %) cases). Bleeding requiring blood transfusion and injuries of internal organs, which were restored intraoperatively (grade II), were recorded in laparoscopic and robot-assisted approaches in 4.41 % and 2.25 % of cases, respectively. Complications leading to the loss of organ (nephrectomy, splenectomy) were observed in 2.94 % and 4.49 % of cases, respectively. Intraoperative deaths (grade IV) were not registered.The incidence of postoperative complications was 18.29 %. Minor complications (Clavien-Dindo ≤II) were detected in 16 (6.5 %) patients (laparoscopic approach - 7.35 %, robot-assisted approach - 6.18 %). Serious complications (Clavien-Dindo ≥III) were detected in 29 (11.79 %) cases (with laparoscopic approach - 14.71 %, robot-assisted - 10.67 %). In the group of tumors with the RENAL index 4-6, the incidence of postoperative complications was 14.7 % with the laparoscopic approach, and 7.1 % with the robot-assisted approach; in the RENAL 7-9 group - 21.9 % and 13.0 %, respectively. In the group of tumors of high complexity (RENAL 10-12), only the robot-assisted approach was used, the incidence of postoperative complications was 22.0 %.Conclusion. Partial nephrectomy for kidney tumors is an effective and safe surgical technique. The incidence of complications when using the laparoscopic approach is higher than when using the robot-assisted technique in groups of tumors of simple and medium complexity. For tumors of high complexity, robot-assisted approach is a priority. The largest number of serious complications is observed with partial nephrectomy with complex tumors.
Pharmacoeconomic aspects of the therapy for moderate and severe psoriatic arthritis
Authors: Rudakova A. V. , Tolkacheva D. G. , Sokolova V. D. 
Published: July 2021

Objective: to perform cost-effectiveness analysis of the treatment for adult patients with psoriatic arthritis (PsA) with a Russian interleukin- 17А inhibitor netakimab in comparison with other biologic disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs) and to evaluate the influence of the inclusion of netakimab in the therapy for PsA on the budget of the Russian healthcare system.Material and methods. The evaluation of cost-effectiveness was performed from the position of the Russian healthcare system for patients with moderate and severe PsA. The evaluation was performed based on the results of the network meta-analysis of the randomized clinical studies. The criterion of clinical effectiveness included the changes in the condition of the joints by the criteria of the American College of Rheumatology (ACR20, ACR50, and ACR70) and changes in skin symptoms by the index of the prevalence and severity of psoriasis (PASI 75 and PASI 90) with a recalculation into quality-adjusted life-year (QALY). The time horizon of the cost-effectiveness analysis was 2 years. The calculation was based on the registered prices and VAT. If there was an original drug and a biosimilar registered on the pharmaceutical market, the calculation was based on the median of the registered prices. The budget impact analysis of the influence of netakimab inclusion in the therapy for patients with PsA was performed considering the structure of the prescription of bDMARDs and tsDMARDs that was determined in the pharmaco-epidemiological study conducted in the Russian Federation in 2020. The analysis was performed for patients that received medication by the scheme of reimbursement. The time horizon of the study was 3 years old.Results. In the base-case analysis, the cost-effectiveness ratio for netakimab was 1.210 mln rub/QALY (by 66.2–88.5% lower than in cases when comparison drugs were used). The budget impact analysis showed that the inclusion of netakimab in the therapy for PsA could reduce the costs by 376.60 mln rub (21.1%). Considering budget saving, the number of additional patients that can be treated will increase by 26.7% within 3 years.Conclusion. Netakimab is characterized by higher cost-effectiveness in comparison with other bDMARDs (adalimumab, golimumab, guselkumab, ixekizumab, infliximab, secukinumab, ustekinumab, certolizumab pegol, etanercept) and tsDMARDs (apremilast, tofacitinib) prescribed in the Russian Federation for patients with PsA. The inclusion of netakimab in the therapy for PsA will reduce the financial burden on the healthcare system.
Why Do My Squiggles Look Funny? A Gallery of Compromised Seismic Signals
Authors: Ringler Adam T. , Mason David B. , Laske Gabi , Storm Tyler , Templeton Mary 
Published: July 2021

Abstract
Seismic instruments are highly sensitive and capable of recording a large range of different Earth signals. The high sensitivity of these instruments also makes them prone to various failures. Although many failures are very obvious, such as a dead channel, there are other more subtle failures that easily go unnoticed by both network operators and data users. This work documents several different types of failure modes in which the instrument is no longer faithfully recording ground-motion data. Although some of these failure modes make the data completely unusable, there are also a number of failures in which the data can still be used for certain applications. Of course, the ideal situation is to identify as soon as possible when data become compromised and to have the network operator fix the station. However, knowing how the data became compromised can also help data users to identify if the data can still be used for their particular application. This work in no way attempts to exhaustively document recording failures but rather to communicate examples and equip the reader with ways of identifying failure modes.
Osteoporosis: A silent disease fraught with fragility fractures in geriatric population
Authors: Vashisht Arun 
Published: July 2021

As per the Population Census2011, the elderly (aged 60 years or above) population in India was about 104 million (53 million females and 51 million males). As per United Nation Population Fund and Help Age India report speculated this number to rise to 173 million by 2026. The purpose of this article is to review the available literature regarding the different ways at hand for osteoporosis evaluation and diagnosis, various therapeutic modalities available for treatment and how they can be utilized for prevention of fractures due to insufficiency of bones in consequence of osteoporosis.The recommendations and conclusions have been evolved after the thorough review of various literatures on osteoporosis. The evidence based recommendations are based on systemic reviews, meta-analysis and randomized controlled trials (RCTs), wherever available.The evidences and recommendations extracted after extensive review of literature has been provided for diagnosis, assessment of risks for fractures, pharmacological therapies with life style modifications, treatment duration of bisphosphonate therapy.The evidences and recommendations extracted after extensive review of literature helped in formulating guidelines to provide a concised but complete overview of all aspects of osteoporosis that will definitely help all healthcare professionals.
Analisis Elastisitas Pendapatan Rumah Tangga di Indonesia
Authors: Hafizah Dian , Hakim Dedi Budiman , Harianto Harianto , Nurmalina Rita 
Published: July 2021

Demand for food products is inevitable, this condition is related to food products as a staple food for the sustainability of human life. In Indonesia, the demand for food depends very much on the needs of the people. The purpose of this study is to analyze food demand in Indonesia which is divided into 4 categories of regions: rich cities, poor cities, rich villages, and poor villages need through research that can be obtained about getting assistance in accordance with the consumption demand of people in Indonesia. The research method used secondary data with panel data types obtained from SUSENAS data. The analytical method used to estimate the demand system was through econometrics demand, namely the QUAIDS model and then the data were processed using the SAS program. The results showed a comparison of the total number of households allocated specifically for food if sorted out, namely poor villages were higher then followed by poor cities, rich cities, and rich villages. When there is a change in income, poor rural households and poor cities when the public still responds by allocating a large part of their budgets to very basic trade such as other food and tobacco, rice, other oils, and household fats in rich villages and rich cities provide more responses to allocating their incomes to the trade in meat, fruits, vegetables, fish, eggs, milk, and processed foods.

Keywords: Quadaric Almost Ideal System, income elasticity, consumption, demand food
MOLECULAR PROPERTIES, BIOACTIVITY SCORES, AND TOXICITY PREDICTIONS OF THE PHYTOCONSTITUENTS PRESENT IN BAUHINIA ACUMINATA
Authors: Kudumula Neelima , Divya Noota , Sravika Nagamalla , Priya Saketha , Anusha Pachava , Sai Jyotsna Mudavath 
Published: July 2021

ABSTRACT:
To develop the herbal drug with the least side effects, there are superior opportunities to discover the medicinal and other biological properties. Natural products serve as sources of beneficial chemical molecules. For this study, Bauhinia acuminata an important medicinal plant of the Indian subcontinent that belongs to the family Fabaceae was chosen. The plant is well known for its precautionary action in tuberculosis. It has been established to possess some pharmacological activities such as membranes Stabilizing activity1, antibacterial2, anti-nociceptive3, thrombolytic activity4, antioxidant5, anthelmintic6, anti-diarrheal7, Hepato-protective 8.
Phytoconstituents present in Bauhinia acuminata obey Lipinski's rule (MiLog P <5) except Kaempferol-3-glucoside indicated their drug-likeness property. Rhoeagenine, 9, 12, 15-octadecatrienoic acid, and 9, 12-octadecadienoic acid are the phytoconstituents showing all types of binding with all types of receptors binding except Kinase inhibitor activity.
Rhoeagenine, Alpha humulene, 9, 12, 15-octadecatrienoic acid, 9, 12-octadecadienoic acid, Alpha muurolol, Beta-sitosterol, Kaempferol-3-glucoside are the phytoconstituents that are free from any type of toxicity. The accurate prediction scores can be used as monographs by researchers and scientists for the development of potential Semisynthetic and synthetic drugs for multifarious usage.
Local Stability Dynamics of Equilibrium Points in Predator-Prey Models with Anti-Predator Behavior
Authors: Harianto Joko , Suparwati Titik , Dewi Alfonsina Lisda Puspa 
Published: July 2021

This article describes the dynamics of local stability equilibrium point models of interaction between prey populations and their predators. The model involves response functions in the form of Holling type III and anti-predator behavior. The existence and stability of the equilibrium point of the model can be obtained by reviewing several cases. One of the factors that affect the existence and local stability of the model equilibrium point is the carrying capacity (k) parameter. If x3∗, y3∗ > 0 is a constant solution of the model and ∈ (0,x3∗), then there is a unique boundary equilibrium point Ek (k , 0). Whereas, if k ∈ (x4∗, y4∗], then Ek (k, 0) is unstable and E3 (x3∗, y3∗) is stable. Furthermore, if k ∈ ( x4∗, ∞), then Ek ( k, 0) remains stable and E4 (x4∗, y4∗) is unstable, but the stability of the equilibrium point E3 (x3∗, y3∗) is branching. The equilibrium point E3 (x3∗, y3∗) can be stable or unstable depending on all parameters involved in the model. Variations of k parameter values are given in numerical simulation to verify the results of the analysis. Numerical simulation indicates that if k = 0,92 then nontrivial equilibrium point Ek (0,92 ; 0) stable. If k = 0,93 then Ek (0,93 ; 0) unstable and E3∗(0,929; 0,00003) stable. If k = 23,94, then Ek (23,94 ; 0) and E3∗(0,929; 0,143) stable, but E4∗(23,93 ; 0,0005) unstable. If k = 38 then Ek(38,0) stable, but E3∗(0,929; 0,145) and E4∗(23,93 ; 0,739) unstable.Keywords: anti-predator behavior, carrying capacity, and holling type III.
PENGARUH PEMBIAYAAN BANK SYARIAH TERHADAP NILAI OUTPUT UMKM: ANALISIS DATA PANEL
Authors: Alghifary Muhammad Syauqy , Kadji Dzuliyati , Kornitasari Yenny 
Published: July 2021

ABSTRAKPenelitian ini bertujuan untuk menganalisis pengaruh perbankan syariah terhadap nilai output UMKM di Indonesia melalui pengujian terhadap pengaruh pembiayaan modal kerja dan investasi bank syariah terhadap nilai output UMKM. Penelitian ini menggunakan pendekatan kuantitatif dengan mengolah data sekunder yang bersifat data panel. Sampel dari data cross section mencakup 33 provinsi di Indonesia dan sampel dari data time series yang bersifat tahunan mengambil rentang waktu tahun 2017-2019. Penelitian ini melibatkan dua variabel kontrol berupa Dana Pihak Ketiga (DPK) dan jumlah tenaga kerja Industri Mikro Kecil di Indonesia. Hasil pengujian menunjukkan bahwa secara simultan variabel pembiayaan modal kerja bank syariah, pembiayaan investasi bank syariah, DPK dan jumlah tenaga kerja berpengaruh signifikan terhadap nilai output UMKM di Indonesia tahun 2017-2019. Maka produk pembiayaan bank syariah dinilai efektif dalam meningkatkan nilai output UMKM.Kata kunci: Pembiayaan Modal Kerja, Pembiayaan Investasi, Bank Syariah, Nilai Output, UMKM. ABSTRACTThis study aims to analyze the effect of Islamic banking on the output value of MSMEs in Indonesia through testing the effect of working capital financing and Islamic bank investment on the output value of MSMEs. This study uses a quantitative approach by processing secondary data that is panel data. The sample of the cross section data covers 33 provinces in Indonesia and the sample of time series data which is annual takes the time span 2017-2019. This study involved two control variables in the form of Third Party Funds (DPK) and the number of workers in the Micro and Small Industry in Indonesia. The test results show that simultaneously the variables of Islamic bank working capital financing, Islamic bank investment financing, DPK and the number of workers have a significant effect on the output value of MSMEs in Indonesia in 2017-2019. So Islamic bank financing products are considered effective in increasing the output value of MSMEs.Keywords: Working Capital Financing, Investment Financing, Islamic Bank, Output Value, MSMEs.