bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conducting Cytocompatible Scaffolds: Composite of Sodium Hyaluronate and Colloidal Particles of Conducting Polymers
Authors: Truong Thanh Huong , Musilová Lenka , Kašpárková Věra , Jasenská Daniela , Ponížil Petr , Minařík Antonín , Korábková Eva , Mráček Aleš , Rejmontová Petra , Humpolíček Petr 
Published: December 2021

Abstract
Novel bio-inspired conductive scaffolds composed of sodium hyaluronate containing water soluble polyaniline or polypyrrole colloidal particles (concentrations 0.108, 0.054 and 0.036 % w/w) were manufactured. For this purpose, either crosslinking with N-(3-dimethylaminopropyl-N-ethylcarbodiimide hydrochloride and N-hydroxysuccinimid or a freeze-thawing process in the presence of poly(vinylalcohol) were used. The scaffolds comprised interconnected pores with prevailing porosity values of ~30 % and pore sizes enabling the accommodation of cells. Good swelling capacity (92 – 97 %) without any sign of disintegration was typical for all samples. The elasticity modulus depended on the composition of the scaffolds, with the highest value of ~50 000 Pa obtained for the sample containing the highest content of polypyrrole particles. The scaffolds did not possess cytotoxicity and allowed cell adhesion and growth on the surface. Using the in vivo-mimicking conditions in a bioreactor, cells were also able to grow into the structure of the scaffolds. The technique of scaffold preparation used here thus overcomes the limitations of conducting polymers (e.g. poor solubility in an aqueous environment, and limited miscibility with other hydrophilic polymer matrices) and moreover leads to the preparation of cytocompatible scaffolds with potentially cell-instructive properties, which may be of advantage in the healing of damaged electro-sensitive tissues.
Geohydraulic and vulnerability assessment of tropically weathered and fractured gneissic aquifers using combined electrical resistivity and geostatistical methods
Authors: AKINGBOYE Adedibu Sunny 
Published: December 2021

Abstract
Sustainable potable groundwater supplied by aquifers depends on the protective capacity of the strata overlying the aquifer zones and their thicknesses, as well as the nature of the aquifers and the conduit systems. The poor overburden development of the Araromi area of Akungba-Akoko, in the crystalline basement of southwestern Nigeria, restricts most aquifers to shallow depths. Hence, there is a need to investigate the groundwater quality of the tropically weathered and fractured gneissic aquifers in the area. A combined electrical resistivity tomography (ERT) and Schlumberger vertical electrical sounding (VES) technique were employed to assess the groundwater-yielding potential and vulnerability of the aquifer units. The measured geoelectric parameters (i.e., resistivity and thickness values) at the respective VES surveyed stations were used to compute the geohydraulic parameters, such as aquifer resistivity (\({\rho }_{o}\)), hydraulic conductivity (K), transmissivity (T), porosity (\(\phi\)), permeability (\({\Psi }\)), hydraulic resistance (\({\text{K}}_{R}\)), and longitudinal conductance (S). In addition, regression analysis was employed to establish the correlations between the K and other geohydraulic parameters to achieve the objectives of this study. The subsurface lithostratigraphic units of the studied site were delineated as the motley topsoil, weathered layers, partially weathered/fractured bedrock units, and the fresh bedrock, based on the ERT and the A, H, AK, HA, and KQ curve models. The K model regression-assisted analysis showed that the \({\rho }_{o}\), T, \(\phi\), \({\Psi }\), and S contributed about 81.7%, 3.31%. 96.6%, 100%, and 11.63%, respectively, of the determined K values for the study area. The results, except T and S, have strong high positive correlations with the K of the aquifer units; hence, accounted for the recorded high percentages. The aquifer units in the area were classified as low to moderate groundwater-yielding potential due to the thin overburden, with an average depth of <4 m. However, the deep-weathered and fractured aquifer zones with depths ranging from about 39–55 m could supply high groundwater yield for sustainable exploitation. The estimated S values, i.e., 0.0226–0.1926 mho, for aquifer protective capacity ratings rated the aquifer units in the area as poor/weak to moderately high with extremely high to high aquifer vulnerability index, based on the estimated low Log \({\text{K}}_{R}\) of about 0.01–1.77 years. Hence, intended wells/boreholes in the study area and its environs, as well as any environments with similar geohydraulic and vulnerability characteristics, should be properly constructed to adequately prevent surface and subsurface infiltrating contaminants.
Global Analysis of a Time Fractional Order Spatio-Temporal SIR Model
Authors: Ammi Moulay Rchid Sidi , Tahiri Mostafa , Tilioua Mouhcine , Zeb Anwar , Khan Ilyas 
Published: December 2021

Abstract
We deal in this paper with a diffusive SIR epidemic model described by reaction-diffusion equations involving a fractional derivative. The existence and uniqueness of the solution are shown, next to the boundedness of the solution. Further, it has been shown that the global behavior of the solution is governed by the value of R0 , which is known in epidemiology by the basic reproduction number. Indeed, using the Lyapunov direct method it has been proved that the disease will extinct for R0 < 1 for any value of the diffusion constants. For R0 > 1, the disease will persist and the unique positive equilibrium is globally stable. Some numerical illustrations have been used to confirm our theoretical results.Subject classification: 26A33; 34A08; 92D30; 35K57.
Stress Analysis of Full-length Bond Bolt Under Shear Deformation of Anchor Interface
Authors: Zhengde ZHU , Xiaoyun SHU , Yun TIAN 
Published: December 2021

Abstract
Bolt anchoring force is closely related to the shear properties of the anchor interface. Considering the shear properties of anchoring agent and contact interface bonding behavior, the shear stress distribution of full-length bond bolt is analyzed based on the stress-strain relationship among bolt, anchoring agent, surrounding rock and bond interface. In this case, both the interface shear stress of the anchoring agent, surrounding rock and the bolt axial force is obtained respectively under drawing and actual working conditions. The results show that the peak shear stress of the interface, including the shear deformation of the contact interface, is significantly lower than that without it when the drawing force is applied. When designing the bolt parameters under the actual working conditions of grade IV and V surrounding rock, the relative deformation between surrounding rock and anchor should be considered, and the distribution of shear stress changes from “unimodal” to “bimodal ”. In the case of a lower elastic modulus of surrounding rock, both the shear stress concentration and distribution range are obvious, and the position of the neutral point is near the orifice. With the increase of elastic modulus, both the shear stress concentration and distribution range are reduced, and the position of the neutral point moves towards the depth of bolt. As a result, the optimum bolt length of full-length bond bolt can be determined by field test and decreases with the increase of elastic modulus of surrounding rock.
Voltammetric Approach for Pharmaceutical Samples Analysis; Simultaneous Quantitative Determination of Resorcinol and Hydroquinone
Authors: Nabatian Ebrahim , Mousavi Mahdi , Pournamdari Mostafa , Ahmadzadeh Saeid 
Published: December 2021

Abstract
A simple and precise analytical approach developed for single and simultaneous determination of resorcinol (RC) and hydroquinone (HQ) in pharmaceutical samples using carbon paste electrode (CPE) modified with 1-Ethyl-3-methylimidazolium tetrafluoroborate as ionic liquid and ZnFe2O4 nanoparticle. A significant enhancement in the peak current and sensitivity of the proposed sensor observed by using modifiers in the composition of working electrode compared to bare CPE which is in accordance with the results obtained from electrochemical impedance spectroscopy investigations. Electrochemical investigations revealed a well-defined irreversible oxidation peak for RC over a wide concentration range from 3.0 µM to 500 µM in 0.1 M phosphate buffer solution (pH 6.0) with the linear regression equations of Ip (µA) = 0.0276 CRC (µM) + 0.5508 (R2 = 0.997). The limit of detection and quantification for RC analysis were found to be 1.46 µM and 4.88 µM, respectively. However, the obtained SW voltammograms for simultaneous determination of RC and HQ exhibited a desirable peak separation of about 360 mV potential difference and a satisfactory linear response over the range of 50-700 µM and 5-350 µM with the favorable correlation coefficient of 0.991 and 0.995, respectively. The diffusion coefficient (D) of RC and the electron transfer coefficient (α) at the surface of ZnFe2O4/NPs/IL/CPE estimated to be 2.83×10−4 cm s−1 and 0.76. The proposed sensor as a promising and low-cost method successfully applied for determination of RC in commercial pharmaceutical formulations such as the resorcinol cream of 2% O/W emulsion available on the market with the recovery of 98.47±0.04.
Construction and Evaluation of a Virtual Reality Laparoscopic Surgery Collaborative Training Platform: Taking Laparoscopic Cholecystectomy as an Example
Authors: Li Weimin , Huang Hui , Li Qin , Zhang Tao , Gao Wenzhe , Zhu Hongwei , Zhang Xianlin , Yu Xiao 
Published: December 2021

Abstract
Backgroud: Virtual reality (VR) technology represents the future of medical education due to its unique advantages, especially with the Covid-19 pandemic lasting. We developed a laparoscopic VR surgery collaborative training platform hoping to shed light on future medical education in China.Methods: We constructed a VR surgery training platform and designed surgery curriculum on laparoscopic cholecystectomy (LC). 36 first-year postgraduate students in China standardized training program for resident doctor (C-STRD) from the Third Xiangya Hospital of Central South University were enrolled for validation trials. In the Phase I trial, 12 students performed LC in the exploration mode. After training in the surgery learning mode, they performed LC again. The LC scores before and after training were compared. In the Phase II trial, another 12 students were randomly assigned to either the collaborative group or the control group. The former trained with a senior surgeon collaboratively in the surgery learning mode and then performed LC alone in the exploration mode. The latter trained in the surgery learning mode by themselves and performed LC in the exploration mode. The LC scores between groups were compared. The user experience (intention to use, skills improvement, usability, degree of enjoyment) were analyzed through questionnaires from the above 24 students. Interest in surgery learning of Phase I students was compared with 12 students who didn’t experience the VR platform.Results: In Phase I trial, the mean LC scores of the students were elevated from 56.83 to 61.17 (p=0.042) after learning in surgery learning mode. In Phase II trial, collaborative group students had higher scores than their rivals (67.17 vs 61.33, p=0.014). Most students have a positive users’ experience regarding the intention to use and skills improvement. Collaborative group students had higher evaluation regarding usability. Students who experienced the VR platform were significantly more interested in future surgery learning (3.60 vs 2.58, p <0.05).Conclusion: Our study constructed a VR platform for collaborative surgery training, which showed an excellent training effect. Medical students rated the platform highly, and their interest in learning increased.
Hypo- and hyper- sensory processing heterogeneity in Autism Spectrum Disorder
Authors: Lefebvre Aline , Tillmann Julian , Cliquet Freddy , Amsellem Frederique , Maruani Anna , Leblond Claire , Beggiato Anita , Germanaud David , Amestoy Anouck , Moal Myriam Ly-Le , Umbricht Daniel , Chattam Christopher , Murtagh Lorraine , Bouvard Manuel , Leboyer Marion , Charman Tony , Bourgeron Thomas , Delorme Richard , Dumas Guillaume 
Published: December 2021

Abstract
Background. Sensory processing atypicalities are part of the core symptoms of autism spectrum disorder (ASD) and could result from an excitation/inhibition imbalance. Yet, the convergence level of phenotypic sensory processing atypicalities with genetic alterations in GABA-ergic and glutamatergic pathways remains poorly understood. This study aimed to characterize the distribution of hypo/hyper-sensory profile among individuals with ASD and investigate the role of deleterious mutations in GABAergic and glutamatergic pathways related genes in sensory processing atypicalities. Method. From the Short Sensory Profile (SSP) questionnaire, we defined and explored a score – the differential Short Sensory Profile (dSSP) - as a normalized and centralized hypo/hypersensitivity ratio for 1136 participants (533 with ASD, 210 first-degree relatives, and 267 controls) from two independent study samples (PARIS and LEAP). We also performed an unsupervised item-based clustering analysis on SSP items scores to validate this new categorization in terms of hypo and hyper sensitivity. We then explored the link between the dSSP score and the burden of deleterious mutations in a subset of individuals for which whole-genome sequencing data were available. Results. We observed a mean dSSP score difference between ASD and controls, driven mostly by a high dSSP score variability among groups (PARIS: p<0.0001, η2 = 0.0001, LEAP: p<0.0001, Cohen’s d=3.67). First-degree relatives were with an intermediate distribution variability profile (p<0.0001). We also reported a positive developmental trajectory of the dSSP score (PARIS: p=0.0006, η2 = 0.02; LEAP: p=0.01, η2 = 0.01). Clusters were similarly characterized by hypo- and hyper-sensitivity items in both study samples (Cramer's V from 0.64 to 0.69, p<0.05). Our genetic analysis showed a trend only for an association with mutations of the GABAergic pathway.Limitations. The major limitation was the dSSP score difficulty to discriminate subjects with a similar quantum of hypo- and hyper- sensory symptoms to those with no such symptoms, resulting both in a similar ratio score of 0.Conclusion. The dSSP score could be a relevant clinical score of the hypo/hyper-sensory individual profile in subjects with ASD. Combined with additional sensory domain characteristics, genetics and endophenotypic substrates, the dSSP score will offer new avenues to explore the underlying neurobiological mechanisms of sensory processing atypicalities in ASD.
Pyrolysis kinetic analysis of sequential extract residues from Hefeng sub-bituminous coal based on Coats-Redfern method
Authors: Huang Xian-Jin , Mo Wen-Long , Ma Ya-Ya , He Xiao-Qiang , Syls Yelixiati , Wei Xian-Yong , Fan Xing , Yang Xiao-Qin , Zhang Shu-Pei 
Published: December 2021

Abstract
Sequential extract residues (Ri, i=1, 2, 3, 4, 5) were obtained from Hefeng acid-washing coal (HFAC) by petroleum ether, carbon disulfide, methanol, acetone and isometric carbon disulfide/acetone mixture, sequentially. Pyrolysis behavior of the samples was carried out using thermogravimetry analysis. Coats-Redfern method with different reaction order was used to analyze the pyrolysis kinetic of each sample, and the kinetic parameters, including correlation coefficient (R2), activation energy (E), pre-exponential factor (A), were calculated. Results showed that the weight loss of extract residues was higher than HFAC, and pyrolysis behavior varies greatly for residues, which may be due to unstable structure after extraction. From conversion-temperature (α-T) curves, pyrolysis process was divided into three stages: low-temperature stage (150-350 oC), medium temperature stage (350-550 oC) and high temperature stage (550-950 oC). And the medium temperature stage made great contribution to the process of pyrolysis, which was dominated by depolymerization and decomposition reaction, and the effect of kinetic fitting to this stage is better, with R2 higher than 0.95. Relationship between kinetic parameters and reaction order showed that swelling effect might be an important reason for the discrepancy of E for each sample in the process of pyrolysis. And Ln(A)-E relationship has a great significance to predict E and the A under higher reaction order.
The Quality of Life of Long Term Survivors of Patients with Biliary Atresia
Authors: Le Melanie , Reinshagen Konrad , Tomuschat Christian 
Published: December 2021

Abstract
Purpose: Advances in surgical techniques and perioperative care have improved patients' short-and mid-term postoperative outcomes with Biliary Atresia (BA). However, the long-term results of these patients have not been thoroughly investigated. This systematic review aims to determine the long-term outcomes and the patients' health-related Quality of life (HrQoL) with their native livers or liver transplantation. Methods: A systematic literature-based search for relevant cohorts was performed using Pubmed/Medline, Cochrane Library from its inception to August 2021. Original studies reporting on BA, Hepatoportoenterostomie, portoenterostomy, Kasai, Liver transplantation, Quality of life, or HrQoL were included. Pooled prevalence has been calculated for cholangitis, secondary liver transplantation, or associated malformations using MetaXL (version 5.3). Subgroup analysis on HrQoL followed surgical treatment after BA was calculated by using RevMan (version 5.4).Results: 12 articles were considered for data synthesis. Nine studies compared biliary atresia patients to an age-matched healthy reference group. 4/9 (n = 338) of these studies indicated lower scores for biliary atresia patients; 5/9 (n = 127) stated similar health status. A Forest plot analysis including all studies with total HrQoL showed a tendency of higher scores towards healthy controls (MD -0.79, 95% CI: -6.00-4.41). Comparing patients after Kasai Hepatoportoenterostomy with healthy controls demonstrated favorable outcomes for the control group (MD -3.22, 95% CI: -7.20-0.75) with no statistical significance (p = 0.11). The pooled estimation of the prevalence of cholangitis, secondary liver transplantation and associated malformations are 0.33 (95% CI: 0.06–0.66), 0.59 (95% CI: 0,42–0.75) and 0.13 (95% CI: 0,01–0.33).Conclusion: Biliary atresia patients have an overall high prevalence of progressive liver-related complications and risk of lower HrQoL compared to their healthy peers. Furthermore, those patients who received liver transplantation appear to have the same Quality of life as those living with their native livers. Targeted and evidence-based follow-up procedures and transitional care are essential to meet these patients' long-term care needs. Prospective and multicenter research das focuses on the attributes and predictors of the long-term prognosis of patients with biliary atresia are necessary.
In Situ Synthesis of Polyaniline Based Ceramic Wastes Composites: Dielectric and Electrical Properties
Authors: Sohail M. , Shahzad Adnan , Sayed Mian Gul , Ullah Ihsan , Omer M. , Adnan Adnan , Mabood Fazal , Ahmad Aziz 
Published: December 2021

Abstract
In the present study, ceramic wastes collected from the premises of industrial zone in Peshawar, KP Pakistan were investigated. An effort has been made to recycle and use the ceramic wastes as fillers in polymeric composites. The negative cost ceramic wastes were purified and activated thermally. The elemental composition and pellets of the wastes were investigated through SEM/EDX analysis. Waste/Polyaniline (PANI) composite was synthesized via in-situ free radical polymerization technique. SEM of the composites showed the uniform distribution of fillers particles in the PANI matrix. XRD studies confirmed that the prepared composite material had a face- centered cubic geometry with distinct preferential orientations. Dielectric analysis showed that the materials exhibit active performance at high frequency regions (3MHz to 3GHz) at room temperature. The results show decrease in dielectric losses and capacitance (1.6 pF) at high frequency regions. AC conductivity of the composite has been increased up to 37.95 Scm-1. This revealed the effect of PANI on the ceramic wastes while increasing its conductance performance. This suggests that the composite material can be investigated for use in photovoltaic detectors, electro-responsive capacitors and power applications.
An Innovative Curriculum Development Experience: Emergency Medical Dispatch Role in the Healthcare Transformation Vision of Saudi Arabia
Authors: Alsofayan Yousef , Almakhalas Kharsan , Alabdali Abdullah , Arafat Mohammed , Aljerian Nawfal , Cluntun Ameera , Alshammari Waad , Alharthi Salman , Alhajjaj Fahad , Alowais Jalal , Alsolamy Sami , Mzahim Bandr , Sabbagh Abdulrahman 
Published: December 2021

Abstract

BackgroundHealthcare medical dispatch systems play a fundamental role in the daily operations of prehospital services. This includes facilitating the interpretation of various dispatch-related systems, receiving incident calls, categorizing cases, guiding proper resources deployment, and providing proper instructions before the arrival of healthcare providers. Considering the Kingdom of Saudi Arabia’s (KSA’s) health sector transformation plan as part of Vision 2030, developing an Emergency Medical Dispatch (EMD) Program as part of essential prehospital services will allow rapid and competent healthcare delivery. In this study, our purpose is to describe the curriculum development of the EMD Program to improve the training of dispatchers and to share the experience in the interest of better prehospital dispatch systems.MethodsA selected group of education experts and academics in emergency medical services dispatch were assigned to develop an EMD curriculum over six months. This study aims to describe the approach followed in developing an innovative EMD Program to share the experience and ultimately standardize dispatch-related training programs. The data of this study was collected by reviewing approved documents of the EMD Program including program curriculum, syllabus, logbook, and exam blueprint after approval letters received from the Health Academy, Saudi Commission for Health Specialties.ResultsThe development of the EMD program utilized a consecutive mixed approach staring with a competency-based with backward design method to ensure the achievement of targeted outcomes followed by the Kern Six-step curriculum development model, namely: (1) problem identification and general need assessment; (2) targeted need assessment; (3) goals and objectives; (4) educational strategies; (5) implementation; and (6) evaluation and feedback. This resulted in four comprehensive modules and seventeen competencies throughout the fourteen-week EMD Program. Conclusion As part of the health sector transformation plan in KSA, EMD services play a fundamental role in the daily operations of prehospital healthcare services. Developing an EMD Program with a consecutive mixed approach including a competency-based with backward design method followed by the Kern Six-step curriculum development model led to a set of learning outcomes in the EMD Program including interpreting various dispatch systems, prioritizing incidents, deploying proper resources, and providing pre-arrival instructions to improve the current operations of EMD services, allow rapid access to healthcare facilities, and ultimately save more lives.