bluuebunny/crossref_metadata_2025_split huggingface dataset:
34. BLOOD PRESSURE CONTROL AMONG HYPERTENSIVE PATIENTS IN SANGLAH GENERAL HOSPITAL DURING COVID-19 PANDEMIC
Authors: Kamardi Stanly , Jagannatha Gusti Ngurah Prana , Pradnyana I Wayan Agus Surya , Yasmin AA Ayu Dwi Adelia 
Published: May 2021

Background:
The COVID-19 pandemic presents a challenge to control patients with chronic disease and conditions, because many people have postponed regular visit for chronic health condition such as hypertension. To make things worse, hypertension is the most important comorbidities and predictor of poor outcomes from COVID-19. Blood pressure control become more crucial to be top priority during this pandemic and beyond.

Objective:
The aim of this study is to determine the blood pressure control status among hypertensive patient in outpatient settings during the pandemic, as compared to before the pandemic of COVID-19.

Methods:
This retrospective, comparative cross-sectional study included 108 medical records of patients with hypertension diagnosis in outpatient cardiology clinic, at Sanglah General Hospital in January 2021. The data obtained were blood pressure during pandemic in January 2021, compared to blood pressure in the same patient before the pandemic (before March 2020).

Result:
The proportion of controlled hypertension before pandemic era was 49.1%, and has decreased during the pandemic to 39.8% (p value = 0.123). Wilcoxon signed rank test showed that there was increased systolic blood pressure level between before pandemic compared to during pandemic of COVID-19 (p value = 0.041).

Conclusion:
The optimal management of hypertension become a very important issue during pandemic of COVID-19, since patients with this pre-existing condition could experience severe complications when infected with SARS-CoV-2. The alternatives to hospital and community-based care, such as mobile phone consultation or telemedicine can be developed by the multidiscipline collaboration to increase control status of hypertension.
39. PROGNOSTIC VALUE OF SYSTOLIC BLOOD PRESSURE IN HOSPITALIZED CHRONIC HEART FAILURE PATIENTS IN DR. SARDJITO HOSPITAL
Authors: Adhyatma Amri , Kusumastuti Dyah Adhi , Bagaswoto Hendry Purnasidha , Mumpuni Hasanah 
Published: May 2021

Background:
Heart failure (HF) is a clinical syndrome due to various underlying diseases with high morbidity and mortality. Hypertension is one of the major risk factor leading to heart failure. Intriguingly, some studies showed that higher systolic blood pressure (SBP) in HF patient is associated with better outcome in survival.

Objective:
We aimed to investigate the association of SBP and in-hospital mortality of chronic heart failure (CHF) patients.

Method:
Hospitalized CHF patients were retrospectively collected from Dr. Sardjito Hospital CHF Registry between March 2019 and October 2020. Shock diagnosis at admission was excluded. Blood pressure at admission, demographic characteristic and echocardiography were analyzed. Systolic blood pressure was grouped into SBP < 110 mmHg and SBP ≥ 110 mmHg. In-hospital mortality was the primary endpoint in this study. Bivariate and multivariate analyses were performed.

Result:
A total of 345 patients were included where 10 patients experienced in-hospital mortality. The mean SBP was 121 ± 25 mmHg and diastolic blood pressure was 71 ± 14 mmHg. Hypertension was found in 137 (39.8%) patients whereas ischemic heart disease (IHD) 161 (46.8%) was the leading cause of HF. We found that the SBP < 110 mmHg group was associated with increased in-hospital mortality compared to the SBP ≥ 110 mmHg group (6.7% versus 0.9%) P = 0.004; non-adjusted RR 7.36 (95% CI 1.59–34.13). Logistic regression analyzing age (≥70 y.o.), obesity, diabetes mellitus, sex, LVEF < 50% and IHD resulted in adjusted OR 6.42 (95% CI 1.29–31.85) with P = 0.023.

Conclusion:
Low blood pressure (SBP < 110 mmHg) was associated with poor outcome in CHF patients.
41. INTRADIALYTIC HYPERTENSION PROFILE IN ROUTINE HEMODIALYSIS PATIENTS: A SINGLE CENTRE EXPERIENCE
Authors: Hustrini Ni Made 
Published: May 2021

Background:
Intradialytic hypertension is a common complication occuring during hemodialysis with the prevalence of 5–15%. It is a paradoxical rise in blood pressure (BP) during or immediately after dialysis, an opposite phenomenon of hemodynamic response to ultrafiltration. Intradialytic hypertension is associated with adverse cardiovascular outcome and can predict cardiovascular mortality.

Aim of the study:
The purpose of this study was to evaluate the intradialytic hypertension profile among maintenance hemodialysis patients.

Methods:
We conducted an observational study on our routine hemodialysis patients in Dr. Cipto Mangunkusumo General Hospital, Jakarta, from 1 February to 31 May 2019. We recruited 133 patients, undergone twice weekly hemodialysis at five hours per session. Intradialytic hypertension was defined as a rise in systolic blood pressure >10 mmHg from pre to immediately post dialysis.

Results:
Among 133 subjects, the median age is 51 years old, with predominantly male (n = 68, 51.1%). Median of the dialysis vintage is 5 years and 28.6% of our patients had diabetes (n = 38). Most of our dialysis patients taking antihypertensive medications (n = 108, 81.2%) with ACE-i/ARB and CCB are the majority agents used (41.4% and 56.4%, respectively). More than half of the subjects achieved less than 5% interdialytic weight gain (IDWG) (n = 69, 51.9%) with median of IDWG is 4.91 liter.
Intradialytic hypertension was found in 33.1% (44/133) subject. We identified no significant different from those experienced intradialytic hypertensions and those who did not, in terms of age and interdialytic weight gain (IDWG) although there is a trend in younger (<60 years old) subject and those achieving IDWG less than 5% to have a lower chance from developing intradialytic hypertension (p = 0.09, 95% CI = 0.230–1.118, OR 0.507 and p = 0.158, 95% CI = 0.286–1.229, OR = 0.593, respectively). There is a higher risk experiencing intradialytic hypertension in those dialysis with higher dialysate calcium concentration (p = 0.075, 95% CI = 0.931–4.036, OR = 1.939), shorter dialysis vintage (p = 0.06, 95% CI = 0.964–4.394, OR = 2.058) and those with higher number of antihypertensive medication used (p = 0.158, 95% CI 1.454–33.696, OR = 7.0 [three agents compared to single agents]), although it is not statistically significant. There is a slightly lower mean ultrafiltration (UF) volume in those developing intradialytic hypertension compare to subject who did not (mean UF 3668 ml vs 3700 ml, p = 0.893). We found a significant different in hemoglobin concentration with a 2.5 times chance of developing intradialytic hypertension in subject who have lower hemoglobin concentration (p = 0.018, 95% CI 1.158–5.334, OR 2.486).

Conclusion:
Intradialytic hypertension is a major hemodialysis complication observed in our unit with a higher risk found in subject with lower hemoglobin concentration. Any attempt to achieving better dialysis adequacy including optimal hemoglobin level are required to lower this complication.
48. BLOOD PRESSURE ON ADMISSION CHARACTERISTIC IN PATIENT WITH ACUTE CORONARY SYNDROME
Authors: Adam Mochamad Faisal , Harlyjoy Bambang Widyantoro Beta Canina , Juzar Dafsah A 
Published: May 2021

Background:
Blood pressure had been a valuable diagnostic tool in cardiovascular disease, such as acute coronary syndrome (ACS). Nevertheless, ample studies have shown that blood pressure in ACS patients had a J-curve prognosis and known as a predictor of myocardial damage. High blood pressure is believed as a sign of larger size of viable myocytes that could still compensate the extent of injury happening during ACS.

Objective:
To compare the blood pressure on admission characteristic in patients presenting with acute coronary syndrome at National Cardiovascular Center Harapan Kita (NCCHK).

Methods:
We collected medical record data of acute coronary syndrome patients in NCCHK from January to December 2020.

Results:
This study included 1383 patients, with median age of 59: 27–94, 78.1% male patients, and 70.4% had history of hypertension. ST-segment elevation myocardial infarction (STEMI) happened in 34.3% of the patient. From our analysis, it showed that patients presenting with STEMI had lower systolic blood pressure (SBP) compared to those with the diagnosis of Non-ST segment elevation myocardial infarction (NSTEMI) or unstable angina pectoris (UAP) (124: 60–255 vs 131: 63–255 vs 136: 71–236, p = 0.000). In the subset of patients with prior hypertension, SBP in STEMI patients remained lowest compared to NSTEMI and UAP patients (132: 60–255 vs 137: 63–255 vs 142: 71: 236, p = 0.000).

Conclusion:
Subjects with STEMI, considered as those with the most extensive myocardial damage, have lowest SBP on admission compared to ACS patients without ST segment elevation even in the subset population with prior hypertension.
54. COMPARATION OF D-DIMER LEVELS IN HYPERTENSIVE AND NON-HYPERTENSIVE ADULT COVID-19 PATIENTS
Authors: Andina Tantika , Tampubolon Daulat JPM 
Published: May 2021

Background:
Coagulopathy is an important clinical feature of Coronavirus Disease 2019 (COVID-2019) associated with severe conditions, making D-dimer useful as a prognostic tool to predict severity and mortality of COVID-19. Hypertension also caused elevated D-dimer levels.

Objective:
This study aims to compare D-dimer levels in hypertensive and non-hypertensive COVID-19 patients.

Methods:
Cross-sectional study was conducted on 96 adult COVID-19 patients admitted between October 2020 and January 2021. Patients with diabetes mellitus, pregnancy/postpartum and malignancy were excluded. D-dimer levels were compared using independent T-test or Mann-Whitney test. Age, sex and severity of COVID-19 were adjusted using subgroup analysis.

Result:
96 COVID-19 patients who were mostly (56.8%) males with 57 subjects (71.25%) younger than 60 years old were included in the analysis. 48 (50%) subjects were hypertensive. Median D-dimer levels of hypertensive and non-hypertensive COVID-19 patients were 1,021.0 (154.0–10,000) and 503.5 (204.0–2,798.0) respectively. The difference between median D-dimer levels of hypertensive and non-hypertensive was significant (p = 0.004). The difference, however, was only found in subjects younger than 60 years old and those with mild symptoms, indicating that age and severity may contribute to D-dimer level.

Conclusion:
D-dimer level was significantly higher in hypertensive COVID-19 patients compared to non-hypertensive patients. Age and disease severity also affect D-dimer levels in COVID-19 patients
59. DIFFERENCES IN EJECTION FRACTION BASED ON LEFT VENTRICULAR GEOMETRIC PATTERN IN HYPERTENSIVE PATIENTS
Authors: Azzuhdi Muhammad Zakiy , Fernando Harben , Maulana Giovanno R , Yanni Mefri 
Published: May 2021

Background:
Left ventricular (LV) geometric patterns and LV ejection fraction (LVEF) have a strong prognostic value in hypertensive patients. However, the differences in EF among various abnormal LV geometric pattern types, including Concentric Remodelling (CR), Concentric Hypertrophy (CH), and Eccentric Hypertrophy (EH), in hypertensive patients is still less studied.

Objective:
To evaluate the differences in LVEF among various types of abnormal LV geometric patterns in hypertensive patients with reduced EF (<50%).

Methods:
We collected data from clinical echocardiographic database of patients at DR. M. Djamil Hospital, Padang, in 2019. The inclusion criteria included hypertension, LVH, and LVEF < 50%. Subjects were divided into three groups based on LV geometric patterns, i.e. CR, CH, and EH groups. Statistical analysis was performed by STATA.

Results:
In this study, 54 hypertensive patients (41 males, 13 females) with mean age of 61.33 ± 13.43 years were included. We found that in hypertensive patients with reduced EF, CH was the most common abnormal LV geometric pattern (50%), followed by EH (44.4%), and CR (5.56%). There was a significant difference in EF among the three groups (p = 0.03), with EH had the lowest EF (35.63 ± 8.79%), followed by CH (41.30 ± 5.44%) and CR (44.67 ± 6.66%).

Conclusions:
Our study demonstrated that LV eccentric hypertrophy has the lowest ejection fraction compared to the other two of abnormal LV geometric pattern in hypertensive patients with reduced ejection fraction. Thus, we suggested that the prognosis of hypertensive patients is potentially worsened by LV eccentric hypertrophy condition.
61. LEFT VENTRICULAR GEOMETRY PATTERN OF HYPERTENSION PATIENTS WHO UNDERTAKING ECHOCARDIOGRAPHY AT AL-IHSAN HOSPITAL BANDUNG ON 2018-2019
Authors: Wulandari Putri , Tiksnadi Badai Bhatara , Djajakusumah Tony S. , Akbar Mohammad Rizki 
Published: May 2021

Background:
Hypertension can induce changes in structures and functions of the heart as the Hypertension Mediated Organ Damage (HMOD). The most common subclinical symptoms of HMOD are Left Ventricular Hypertrophy (LVH), which is one of the Left Ventricular (LV) geometry. LV Geometry has prognostic significance.

Objective:
To describe LV geometry pattern of hypertension patients who undertaking echocardiography at Al-Ihsan Hospital Bandung.

Method:
This is a descriptive, cross-sectional study using medical record and the echocardiography result from January 2008–December 2019. Hypertension was defined as patient diagnosed with a code I10 (essential hypertension), I11 (hypertensive heart disease) based on ICD X, and/or patients with a history of hypertension. The exclusion criteria were samples with incomplete data of medical records and echocardiography results. The LV geometry was determined by re-calculation of relative wall thickness (RWT) and left ventricular mass index (LVMI).

Result:
There were 123 of 6247 hypertension patients, female (66.7%), age 60 ± 12 years, obesity (49.6%), CAD (24.4%), DM II (27.6%), rEF (23.6%), VHD (30.1%). LV geometry patterns were concentric LVH (49 pts/40%), eccentric LVH (41 pts/33%), normal geometry (22 pts/18%), and concentric remodeling (11 pts/9%). Concentric LVH tends to occur in women, age >65 years, and obese patients. Eccentric LVH tends to occur in patients with comorbid CAD, VHD, rEF, and DM II. Concentric remodeling and normal geometry are never dominant as the most pattern of geometry in hypertension patients.

Conclusion:
The LV geometry of hypertension patients majority have experienced LVH with the most pattern is concentric LVH.
62. RESISTIVE INDEX OF INTERNAL CAROTID ARTERY AND COMMON CAROTID ARTERY IN PATIENTS WITH CEREBRAL SMALL VASCULAR DISEASE
Authors: Rinjani Ansi , Mesiano Taufik , Andini Putri Widya , Yugo Mohammad Reynalzi , Yunus Reyhan Eddy , Kurniawan Mohammad , Hidayat Rakhmad , Rasyid Al , Harris Salim 
Published: May 2021

Background/Objective:
Cerebroarterial pulsatility has been reported to be significantly increased in patients with cerebral small vessel disease (CSVD). Resistive index (RI) is a parameter of pulsatility and describes resistance of the vascular wall. This study aims to describe RI of internal carotid artery (ICA) and common carotid artery (CCA) in CSVD.

Methods:
This retrospective study evaluated the registry in Neurosonology Lab, between January and June of 2020. Patients were categorized into CSVD and non CSVD diagnosed using brain scan or MRI. CSVD markers such as lacune, microbleeds, perivascular space, and fazekas class are evaluated from MRI. RI of ICA and CCA were measured using Carotid Doppler Ultrasound. Uni- and bivariate analysis were done to evaluate the mean difference.

Result:
There were 79 subjects with a median age of 60 (49–66) years, comprising 54.4% with CSVD. RI in CSVD was not significantly higher than non CSVD and tended to be lower. RI of patients with CSVD markers such as lacune (ICA 0.69 ± 0.9, CCA 0.77 ± 0.08), microbleeds (ICA 0.68 ± 0.06, CCA 0.72 ± 0.08), perivascular space > 11 (ICA 0.80 ± 0.17, CCA 0.77 ± 0.05) and fazekas ≥2 (ICA 0.69 (0.09), CCA 0.76 (0.08)) tended to be higher than normal population.

Conclusions:
This study did not find a significantly higher RI in CSVD compared to non-CSVD, but RI of ICA and CCA in CSVD patient has a tendency to be higher than normal population. Further studies with larger sample sizes are needed to determine role of RI.
63. AMELIORATION OF CARDIAC HYPERTROPHY BIOMARKERS BY DECAFFEINATED LIGHT ROASTED GREEN COFFEE EXTRACT IN METABOLIC SYNDROME RAT MODEL
Authors: Nugroho Dwi Adi , Lukitasari Mifetika , Kholis Mukhammad Nur , Wahyuni Nila Aisyah , Rohman Mohammad Saifur 
Published: May 2021

Background:
Metabolic syndrome is associated with increased prevalence of cardiac hypertrophy. The effect of coffee consumption on cardiovascular outcome is still controversial due to its caffeine content.

Objective:
This study aimed to investigate the effect of light roasted decaffeinated green coffee extract (GCE) on amelioration of cardiac hypertrophy biomarkers in metabolic syndrome rat model

Methods:
Twenty five metabolic syndrome rat model were divided into GCE 100, 200, 250 group, normal control (NC) and metabolic syndrome (MS) group. Rats in the GCE groups were treated once daily with green coffee extract at a dose of 100, 200, and 250 mg/bw.t respectively. The extract was given for 9 weeks through oral gavage. The metabolic syndrome parameters were measured every two weeks by colorimetric method. Blood pressure was determined by tail cuff blood pressure recorder. Angiotensin 2 level was analysed by ELISA method. Cardiac TNFα, IL6, NFKβ, RAC1 and BNP gene expression was analysed by RT-PCR methods.

Results:
The metabolic syndrome parameters were significantly in all GCE groups after administration of green coffee extract for 9 weeks. The lowest angiotensin 2 level were observed in GCE 250 group compared to that of MS and GCE 100 and 200 group. The cardiac TNFα, IL6, NFKβ, RAC1 and BNP gene expression were significantly lower in all GCE group (p < 0.000) compared to that of MS group. However, in GCE 100 group the expression of those genes was the lowest among all GCE groups.

Conclusion:
This study suggested that the administration of GCE 100 mg/bw.t ameliorated angiotensin 2 level and cardiac hypertrophy biomarker in metabolic syndrome rat model.
72. MYOCARDIAL FIBROSIS IN HYPERTENSIVE PATIENTS: A NOVEL TARGET IMAGING BIOMARKER
Authors: Damaiati NE , Atmadikoesoemah CA , Elen  , Kasim M 
Published: May 2021

Background:
Myocardial fibrosis is essential in pathological basis of many cardiovascular diseases. Cardiac magnetic resonance (CMR) using T1 mapping serves to identify interstitial fibrosis in many cases, one of which is hypertension. It is suggested that T1 mapping in hypertensive patients compared to other cardiovascular risk factors share similar values that is strongly linked to cardiovascular morbidity including increased ischemic burden, decreased systolic function, and cardiovascular death.

Objective:
To identify the extend of myocardial fibrosis in hypertensive patients compared to other cardiovascular risk factors.

Methods:
The study was conducted in Department of Cardiology and Vascular Medicine Universitas Indonesia/National Cardiovascular Center Harapan Kita. Analysis was performed on data extracted from cardiac magnetic resonance examinations on all hypertensive patients consulted to the imaging division in January-December 2018. A total of 120 subjects underwent scanning on a 1.5-Tesla Philips Achieva scanner. At rest, mid LV native T1 map was acquired using the Look-Locker methods.

Results:
Overall, the majority of participants were male (73%) with mean age of 57.22 ± 10.01 years and mean body mass index of 25.75 ± 4.40. The number of subjects with diabetes mellitus, dyslipidemia, and smokers were 40%, 50%, and 22% respectively. There is no difference between T1 value of patients who were hypertensive with no other cardiovascular risk factors (n = 19, mean T1 1253.63 ± 347.48) and hypertensive patients carrying other risk factors (n = 34, mean T1 1250.66 ± 365.42), p = 0.75. In addition, both groups showed no difference in terms of left ventricular systolic function with mean ejection fraction (EF) of 48.6% in those with hypertension alone and EF of 45.4% in hypertensive patients with other additional risk factors (p = 0.48).

Conclusion:
Hypertension alone had similar extent of myocardial fibrosis to those with any other additional cardiovascular risk factors. Since extent of myocardial fibrosis is strongly linked to cardiovascular death, this finding should be brought into more careful investigation in the future.
75. MORE FREQUENT REHOSPITALIZATION IN HEART FAILURE PATIENTS WITH HYPERTENSION
Authors: Widasmara Seprian , Aziz Indra Jabbar , Rohman Mohammad Saifur 
Published: May 2021

Introduction:
Heart Failure (HF) is the most common heart disease in the world and is increasing in prevalence. Despite the significant advances in therapies and prevention, mortality and morbidity are still high, poor quality of life and recurrent rehospitalization. Therefore, HF health expenditures are also considerable. Hypertension was the most common risk factor for CHF. However, no obvious data regarding recurrent rehospitalization in heart failure patients with hypertension in Indonesia

Objective:
The study aimed to compare recurrent rehospitalization of patients with heart failure with hypertension and without hypertension

Method:
We completed a descriptive analytic from heart failure registry of Dr Saiful Anwar Hospital. Baseline characteristic, hypertension treatment, length of stay, hospital mortality, recurrent rehospitalization and others data also analyze to compare between hypertension and non-hypertension patients.

Result:
A total of 1163 patients were included in this study. 28.5% of admitted HF patients suffered from hypertension. Interestingly, 27.9% of sample has been recorded as history of recurrent re-hospitalization. There was no significant difference in length of stay between heart failure patients with hypertension and without hypertension (mean = 6.68 ± 4.51; p = 0.453). However, the proportion of patient with hypertension experienced more frequent rehospitalization as compare non hypertension HF patient.

Conclusion:
HF patients with hypertension experienced more frequent hospitalization in this study