bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Perspectives on Telemedicine During the COVID-19 Pandemic
Authors: Ahmad Farhan , Wysocki Robert W. , Fernandez John J. , Cohen Mark S. , Simcock Xavier C. 
Published: September 2021

Background Patients received care over telemedicine during the COVID-19 pandemic, and their perspective is useful for hand surgeons. Methods Online surveys were sent October-November 2020 to 497 patients who received telemedicine care. Questions were free-response and multi-item Likert scales asking about telehealth in general, limitations, benefits, comparisons to in-person visits, and opinions on future use. Results The response rate was 26% (n = 130). Prior to the pandemic, 55% had not used telemedicine for hand surgery consultation. Patients liked their telemedicine visit and felt their provider spent enough time with them (means = 9/10). In all, 48% would have preferred in-person visits despite the pandemic, and 69% would prefer in-person visits once the pandemic concludes. While 43% had no concerns with telemedicine, 36% had difficulties explaining their symptoms. Telemedicine was easy to access and navigate (M = 9/10). However, 23% saw telemedicine of limited value due to the need for an in-person visit soon afterward. Of these patients, 46% needed an in-person visit due to inadequate physical examination. Factors that make telemedicine more favorable to patients included convenience, lack of travel, scheduling ease, and time saved. Factors making telemedicine less favorable included need for in-person examination or procedure, pain assessment, and poor connectivity. There was no specific appointment time the cohort preferred. Patient recommendations to improve telemedicine included decreasing wait times and showing patient queue, wait time, or physician status online. Conclusions Telemedicine was strongly liked by patients during the COVID-19 pandemic. However, nearly 70% of patients still preferred in-person visits for the future.
Women in neurointervention, a gender gap? Results of a prospective online survey
Authors: Power Sarah , Biondi Alessandra , Saatci Isil , Bennett Kathleen , Mahadevan Jeyaledchumy , Januel Anne Christine , Singhara Na Ayudhaya Sirintara (Pongpech) , Agid Ronit 
Published: September 2021

Background and Purpose Women's representation in medicine has increased over time yet the proportion of women practicing neurointervention remains low. We conducted an anonymous online survey through which we could explore the gender gap in neurointervention, identify potential issues, difficulties, or obstacles women might face, and evaluate if men encounter similar issues. Methods An online questionnaire was designed in SurveyMonkey®. Invitation to participate was emailed through national and international neurointerventional societies as well as directly through private mailing lists to men and women working in neurointervention. Responses were collected from 10 May 2019 to 10 September 2019. Results There were 295 complete responses, 173 (59%) male and 122 (41%) female. Most respondents (83%) fell within age categories 35–60 years, with representation from 40 countries across five continents. In all 95% were working full time, 73% had worked as a neurointerventionalist for >6 years, 77% worked in University-affiliated teaching institutions. Almost half of the respondents indicated no female neurointerventionalist worked in their center. Female respondents were younger and age-adjusted analysis was undertaken. Significantly fewer females than males were married and had children. Significantly fewer females held supervisory roles, held academic titles, and significantly less had a mentor. Females were less satisfied in their careers. More females felt they receive less recognition than colleagues of the opposite sex. Males had a greater proportion of work time dedicated to neurointervention. Similar proportions of both genders experienced bullying in work (40%–47%); however, sexual harassment was more common for females. There were no differences between genders in how they dealt with complications or their effects on mental well-being. Conclusion There are many potential reasons why women are underrepresented in neurointervention, however, the literature suggests this is not unique to our specialty. Multiple long-term strategies will be necessary to address these issues, some of which are discussed in the article.
Thrombectomy for distal medium vessel occlusion with a new generation of Stentretriever (Tigertriever 13)
Authors: Guenego Adrien , Mine Benjamin , Bonnet Thomas , Elens Stephanie , Vazquez Suarez Juan , Jodaitis Lise , Ligot Noémie , Naeije Gilles , Lubicz Boris 
Published: September 2021

Purpose To evaluate the safety and efficacy of the Tigertriever 13 (Rapid Medical, Yoqneam, Israel) stent retriever in acute ischemic stroke (AIS) patients with primary or secondary distal, medium vessel occlusions (DMVO). Methods We performed a retrospective analysis of all consecutive AIS patients who underwent thrombectomy with the Tigertriever13 for DMVO. Patients’ characteristics were reviewed, procedural complications, angiographic (modified thrombolysis in cerebral infarction score [mTICI]) and clinical (modified Rankin Scale [mRS]) outcomes were documented. Results Between November 2019 and November 2020, 16 patients with 17 DMVO were included (40% female, median age 60 [50–65] years). The Tigertriever13 was used in 11/17 (65%, median NIHSS of 8 [6–15]) primary DMVO and in 6/17 (35%, median NIHSS of 20 [13–24]) cases of secondary DMVO after a proximal thrombectomy. The successful reperfusion rate (mTICI 2b, 2c, 3) was 94% (16/17) for the dedicated vessel. At day 1, CT imaging showed a subarachnoid hemorrhage in 29% of the cases and a parenchymal hematoma in 12%. At 3 months, 65% of the patients (11/17) had a favorable outcome (mRS 0–2). Conclusion Mechanical thrombectomy using the Tigertriever13 appears to be safe and effective for DMVO. Clinical and anatomical results are in line with those of patients with proximal occlusions.
‘Recommended for you’: A distant reading of BBC iPlayer
Authors: Kelly JP 
Published: September 2021

Video-on-demand (VOD) interfaces have become a ubiquitous feature of contemporary screen culture. But despite their prevalence and the significant amount of time we spend in these liminal spaces, these interfaces are – within the field of TV studies at least – relatively under-theorised and rarely the subject of focused critical interrogation. Indeed, it has been noted that there are simply ‘no established methodologies in TV studies for studying interfaces’ (Johnson, 2017: 124). In addressing this methodological gap, this article develops and demonstrates an empirical and quantitative approach to the analysis of television VOD interfaces, taking its cue from ‘distant reading’ ( Moretti, 2013 ).
A detailed analysis of long-term outcomes following reconstruction for congenital thumb hypoplasia
Authors: Mende Konrad , Suurmeijer José Annelie , Mason Will T.M. , Smith Belinda J. , Tonkin Michael A. 
Published: September 2021

This retrospective study analyses long-term outcomes of reconstruction for congenital thumb hypoplasia Grades 2 and 3 A. In 22 thumbs (mean follow-up 9 years), instability of the metacarpophalangeal joint was found in 20 thumbs regardless of the method of reconstruction, double breasting of local tissue with or without adductor pollicis advancement or use of a slip of flexor digitorum superficialis to supplement local tissue. There was a trend towards a greater global strength, higher Kapandji score and better subjective function score when the abductor digiti minimi was used as an opposition transfer as compared with the flexor digitorum superficialis. Results for motion and subjective parameters were consistent with comparable studies though these comparisons are compromised by different methods of classification and assessment. Consistent application of an expanded Blauth grading system and a formal hypoplastic thumb score will improve the ability to compare pre- and postoperative status, different techniques and results from different centres. Level of evidence: IV
Characteristics of chronic thromboembolic pulmonary hypertension in Ireland
Authors: Cullivan Sarah , McCormack Ciara , O’Callaghan Marissa , Kevane Barry , NiAinle Fionnuala , McCullagh Brian , Gaine Sean P. 
Published: September 2021

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and under‐recognised complication of acute pulmonary embolism. Information regarding the characteristics of CTEPH in Ireland is limited, and the aim of this retrospective cohort study was to address this knowledge gap. Seventy‐two cases of CTEPH were diagnosed in the National Pulmonary Hypertension Unit (NPHU) in Ireland between 2010 and 2020. This accounted for 6% of all referrals to the unit and translates to an estimated annual incidence of 1.39 per million population (95% confidence interval, 0.33–2.46). The prevalence of diagnosed CTEPH in Ireland in 2020 was estimated at 12.05 per million population (95% CI 9.00–15.10). The average duration of symptoms prior to CTEPH diagnosis was 23 (±22) months. Patients with CTEPH were more likely to be male (n = 40, 56%), older (60 ± 17 years) and have identifiable risk factors for CTEPH (n = 61, 85%) at diagnosis. Regarding treatment, pulmonary hypertension (PH) vasodilator therapy was prescribed in 75% (n = 54) within 12 months of diagnosis, inferior vena cava filters were placed in 24% (n = 17) and 97% (n = 70) of cases were anticoagulated. Pulmonary endarterectomy was performed in 35% (n = 25), balloon pulmonary angioplasty in 6% (n = 4). One‐, three‐ and five‐year survival was 93%, 80% and 65% from the time of diagnosis, and this was significantly better in patients who underwent pulmonary endarterectomy (p = 0.01). This is the first study describing the characteristics of CTEPH in Ireland and highlights suboptimal disease recognition and referral for the assessment for pulmonary endarterectomy.
Clinical experience of extreme lateral interbody fusion in the treatment of lumbar spondylodiscitis
Authors: Li Jiaqi , Zhang Peng , Dou Chenghao , Zhang Wei 
Published: September 2021

Introduction Up to now, there were few studies on extreme lateral interbody fusion (XLIF) surgery for lumbar spondylodiscitis. This study was aimed to evaluate clinical effectiveness and provide more information for XLIF in the treatment of lumbar spondylodiscitis. Methods We retrospectively collected cases of XLIF for the treatment of lumbar spondylodiscitis from September 2017 to February 2020. There were 8 cases of non-specific infection of lumbar spine, 4 cases of lumbar tuberculosis, and 1 case of lumbar brucellosis. Basic information, antibiotic application, and inflammatory index were collected before and after surgery. Clinical effectiveness was evaluated at baseline and in 3, 6, and 12 months after the surgery with visual analog scale (VAS) and Oswestry disability index (ODI). The comparison of the indicators before and after the operation was performed by repeated measures analysis of variance. Results The average intraoperative blood loss and operation time was 70mL and 99.23 min, respectively. The study consisted of 13 cases with single segment operation. The average follow-up time was 16.54 months. No sign of recurrence of spondylodiscitis occurred at last follow-up. Postoperative VAS and ODI were significantly decreased after the operation. No major blood vessels, nerves, or organ damage occurred during the perioperative period. Conclusion XLIF has shown good clinical effectiveness in the treatment of lumbar spondylodiscitis with advantages of less bleeding and less tissue damage in the present study. More multi-center prospective comparative studies are needed to further verify the clinical effectiveness of this procedure in lumbar spondylodiscitis.
Clinical Outcomes of Anterolateral Ligament Reconstruction or Lateral Extra-articular Tenodesis Combined With Primary ACL Reconstruction: A Systematic Review With Meta-analysis
Authors: Na Bo-Ram , Kwak Woo-Kyoung , Seo Hyoung-Yeon , Seon Jong-Keun 
Published: September 2021

Background: Residual rotational instability after isolated anterior cruciate ligament reconstruction (ACLR) has been a challenge for many years. Anterolateral extra-articular procedures (AEAPs), including anterolateral ligament reconstruction (ALLR) or lateral extra-articular tenodesis (LET), are performed as a surgical option for additional rotational stability, but clear evidence for their usefulness is lacking. Purpose: To conduct a systematic review and meta-analysis of the literature regarding the efficacy of AEAP in primary ACLR. Study Design: Systematic review; Level of evidence, 3. Methods: A literature search, data extraction, and quality assessment were conducted by 2 independent reviewers. MEDLINE, EMBASE, and the Cochrane Library were searched in April 2020, following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A total of 3444 studies were screened, and 20 studies (11 randomized controlled trials and 9 nonrandomized studies) were evaluated. Functional outcomes, stability, and complications were compared between patients who underwent primary ACLR with AEAP and those who underwent isolated primary ACLR. For subgroup analysis, outcomes were compared according to AEAP technique (ALLR vs LET) and time from injury to surgery (≤12 vs >12 months). The methodological quality of the included studies was assessed using the Cochrane risk-of-bias tool, Jadad scale, and Newcastle-Ottawa Scale. Results: Compared with isolated ACLR, combined ACLR with AEAP led to improved pivot-shift grades and graft failure rates, regardless of the AEAP technique or of time from injury to surgery. A limited, marginal improvement in subjective function score was observed in patients who underwent AEAP combined with ACLR. In contrast to ALLR, patients who underwent LET combined with ACLR had an increased risk of knee stiffness and adverse events. Conclusion: Our review suggests that when there is a need to improve rotational stability and subjective function, AEAP combined with primary ACLR can be considered regardless of time from injury. ALLR appeared to be a better option for improving rotational stability compared with LET.
Sins of Omission: Are junior doctors failing to report clinical incidents, and if so, how can we better support them to do so?
Authors: Bertram Ian , Cantelo Jack , Hutton William , Kirkham Henry , Scallan Nicholas 
Published: September 2021

Objectives University Hospitals Birmingham's (UHB) Foundation Doctors should log clinical incidents via the Trust's incident reporting system. Anecdotal reports suggest under-reporting is commonplace. It is therefore important to identify the proportion of Foundation Year 1 (FY1s) who witnessed but did not report incidents and identify and weigh perceived barriers to reporting. We can then suggest strategies to address these barriers and repeat our data collection. Methodology We performed an analysis of anonymised data from the Trust's Datix Incident Reporting system alongside an anonymised survey to determine the proportion of FY1s witnessing reportable clinical incidents, and the proportion successfully reporting an incident in the 2017/18 academic year. The survey also gathered data on FY1 perceptions of barriers to reporting. We went on to discuss our results with UHB management and suggested several strategies to improve reporting, prior to repeating data collection for the 2019–20 academic year. Results 36.4% FY1 doctors surveyed in 2017–18 reported witnessing at least one clinical incident that they did not report. 37.0% FY1 doctors surveyed in 2019–20 reported the same. Respondents felt time taken to complete forms and system complexity were the key barriers to reporting. Conclusion Results show that over a third of FY1s at UHB had witnessed but not reported at least one clinical incident each year. The evidence-based strategies suggested to the trust in 2018 and 2020 included FY1 education on incident reporting, early senior clinician involvement in the reporting pathway, and a streamlined reporting system integrated with existing infrastructure. These have not been implemented.
How I manage autoimmune cytopenias in patients with lymphoid cancer
Authors: Porpaczy Edit , Jäger Ulrich 
Published: September 2021

Abstract
Autoimmune conditions can occur in a temporary relationship with any malignant lymphoma. In many instances, treatment at diagnosis is not required, but symptomatic autoimmune conditions represent an indication for treatment, particularly in chronic lymphoproliferative diseases. Treatment is selected depending on the predominant condition: autoimmune disease (immunosuppression) or lymphoma (antilymphoma therapy). Steroids and anti-CD20 antibodies are effective against both conditions and may suppress the autoimmune complication for a prolonged period. The efficacy of B-cell receptor inhibitors has provided us with novel insights into the pathophysiology of antibody-producing B cells. Screening for underlying autoimmune conditions is part of the lymphoma workup, because other drugs, such as immunomodulators and checkpoint inhibitors, should be avoided or used with caution. In this article, we discuss diagnostic challenges and treatment approaches for different situations involving lymphomas and autoimmune cytopenias.
GIS-based analysis of spatial–temporal correlations of urban traffic accidents
Authors: Ma Qinglu , Huang Guanghao , Tang Xiaoyao 
Published: September 2021

Abstract
Background
Understanding the spatial–temporal distribution characteristics of urban road traffic accidents is important for urban road traffic safety management. Based on the road traffic data of Wales in 2017, the spatial–temporal distribution of accidents is formed.

Methods
The density analysis method is used to identify the areas with high accident incidence and the areas with high accident severity. Then, two types of spatial clustering analysis models, outlier analysis and hot spot analysis are used to further identify the regions with high accident severity.

Results
The results of density analysis and cluster analysis are compared. The results of density analysis show that, in terms of accident frequency and accident severity, Swansea, Neath Port Talbot, Bridgend, Merthyr Tydfil, Cardiff, Caerphilly, Newport, Denbighshire, Vale of Glamorgan, Rhondda Cynon Taff, Flintshire and Wrexham have high accident frequency and accident severity per unit area. Cluster analysis results are similar to the density analysis. Finally, the temporal distribution characteristics of traffic accidents are analyzed according to month, week, day and hour. Accidents are concentrated in July and August, frequently in the morning rush hour and at dusk, with the most accidents occurring on Saturday.

Conclusions
By comparing the two methods, it can be concluded that the density analysis is simple and easy to understand, which is conducive to understanding the spatial distribution characteristics of urban traffic accidents directly. Cluster analysis can be accurate to the accident point and obtain the clustering characteristics of road accidents.
The significance of biomass allocation to population growth of the invasive species Ambrosia artemisiifolia and Ambrosia trifida with different densities
Authors: Zhao Wenxuan , Liu Tong , Liu Yan , Wang Hanyue , Wang Ruili , Ma Qianqian , Dong Hegan , Bi Xuyi 
Published: September 2021

AbstractBackgroundAmbrosia artemisiifoliaandAmbrosia trifidaare globally distributed harmful and invasive weeds. High density clusters play an important role in their invasion. For these two species, the early settled populations are distributed at low densities, but they can rapidly achieve high population densities in a short period of time. However, their response to intraspecific competition to improve the fitness for rapid growth and maintenance of high population densities remains unclear. Therefore, to determine how these species form and maintain high population densities, individual biomass allocations patterns between different population densities (low and high), and plasticity during seedling, vegetative, breeding and mature stages were compared. In 2019, we harvested seeds at different population densities and compared them, and in 2020, we compared the number of regenerated plants across the two population densities.ResultsMost biomass was invested in the stems of both species.Ambrosia trifidahad the highest stem biomass distribution, of up to 78%, and the phenotypic plasticity of the stem was the highest. Path analysis demonstrated that at low-density, total biomass was the biggest contributor to seed production, but stem and leaf biomass was the biggest contributors to high-density populations. The number of seeds produced per plant was high in low-density populations, while the seed number per unit area was huge in high-density populations. In the second year, the number of low-density populations increased significantly.A. artemisiifoliaandA. trifidaaccounted for 75.6% and 68.4% of the mature populations, respectively.ConclusionsHigh input to the stem is an important means to regulate the growth of the two species to cope with different densities. These two species can ensure reproductive success and produce appropriate seed numbers. Therefore, they can maintain a stable population over time and quickly form cluster advantages. In the management, early detection of both species and prevention of successful reproduction by chemical and mechanical means are necessary to stop cluster formation and spread.
Identification of genetic loci associated with major agronomic traits of wheat (Triticum aestivum L.) based on genome-wide association analysis
Authors: Jung Woo Joo , Lee Yong Jin , Kang Chon-Sik , Seo Yong Weon 
Published: September 2021

Abstract
Background
Bread wheat (Triticum aestivum L.) is one of the most widely consumed cereal crops, but its complex genome makes it difficult to investigate the genetic effect on important agronomic traits. Genome-wide association (GWA) analysis is a useful method to identify genetic loci controlling complex phenotypic traits. With the RNA-sequencing based gene expression analysis, putative candidate genes governing important agronomic trait can be suggested and also molecular markers can be developed.

Results
We observed major quantitative agronomic traits of wheat; the winter survival rate (WSR), days to heading (DTH), days to maturity (DTM), stem length (SL), spike length (SPL), awn length (AL), liter weight (LW), thousand kernel weight (TKW), and the number of seeds per spike (SPS), of 287 wheat accessions from diverse country origins. A significant correlation was observed between the observed traits, and the wheat genotypes were divided into three subpopulations according to the population structure analysis. The best linear unbiased prediction (BLUP) values of the genotypic effect for each trait under different environments were predicted, and these were used for GWA analysis based on a mixed linear model (MLM). A total of 254 highly significant marker-trait associations (MTAs) were identified, and 28 candidate genes closely located to the significant markers were predicted by searching the wheat reference genome and RNAseq data. Further, it was shown that the phenotypic traits were significantly affected by the accumulation of favorable or unfavorable alleles.

Conclusions
From this study, newly identified MTA and putative agronomically useful genes will help to study molecular mechanism of each phenotypic trait. Further, the agronomically favorable alleles found in this study can be used to develop wheats with superior agronomic traits.