bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza
Authors: Bao Linlin , Deng Wei , Qi Feifei , Lv Qi , Song Zhiqi , Liu Jiangning , Gao Hong , Wei Qiang , Yu Pin , Xu Yanfeng , Qu Yajin , Li Fengdi , Xue Jing , Gong Shuran , Liu Mingya , Wang Guanpeng , Wang Shunyi , Zhao Binbin , Cong Bin , Qin Chuan 
Published: May 2021

AbstractInfluenza A virus may circulate simultaneously with the SARS-CoV-2 virus, leading to more serious respiratory diseases during this winter. However, the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the host remains unclear. Using a mammalian model, sequential infection was performed in ferrets and in K18-hACE2 mice, with SARS-CoV-2 infection following H1N1. We found that co-infection with H1N1 and SARS-CoV-2 extended the duration of clinical manifestation of COVID-19, and enhanced pulmonary damage, but reduced viral shedding of throat swabs and viral loads in the lungs of ferrets. Moreover, mortality was increased in sequentially infected mice compared with single-infection mice. Compared with single-vaccine inoculation, co-inoculation of PiCoVacc (a SARS-CoV-2 vaccine) and the flu vaccine showed no significant differences in neutralizing antibody titers or virus-specific immune responses. Combined immunization effectively protected K18-hACE2 mice against both H1N1 and SARS-CoV-2 infection. Our findings indicated the development of systematic models of co-infection of H1N1 and SARS-CoV-2, which together notably enhanced pneumonia in ferrets and mice, as well as demonstrated that simultaneous vaccination against H1N1 and SARS-CoV-2 may be an effective prevention strategy for the coming winter.
The efficacy of an extraoral scavenging device on reducing aerosol particles ≤ 5 µm during dental aerosol-generating procedures: an exploratory pilot study in a university setting
Authors: Graetz Christian , Düffert Paulina , Heidenreich Ralf , Seidel Miriam , Dörfer Christof E. 
Published: May 2021

AbstractObjective/aimTo identify small particle concentrations (eight categories: ≤0.1 µm × ≤5.0 µm) induced by aerosol-generating procedures (AGPs; high-speed tooth preparation, ultrasonic scaling; air polishing) under high-flow suction with a 16-mm intraoral cannula with and without an additional mobile extraoral scavenger (EOS) device during student training.Materials and methodsTwenty tests were performed (16.94 m2room without ventilation with constant temperature (26.7 (1.1) °C and humidity (56.53 (4.20)%)). Data were collected 2 min before, 2 min during, and 6 min after AGPs. The EOS device and the air sampler for particle counting were placed 0.35 m from the open mouth of a manikin head. The particle number concentration (PN, counts/m3) was measured to calculate ΔPN (ΔPN = [post-PN] − [pre-PN]).ResultsMean ΔPN (SD) ranged between −8.65E+06 (2.86E+07) counts/m3for 0.15 µm and 6.41E+04 (2.77E+05) counts/m3for 1.0 µm particles. No significant differences were found among the AGP groups (p > 0.05) or between the AGP and control groups (p > 0.05). With an EOS device, lower ΔPN was detected for smaller particles by high-speed tooth preparation (0.1–0.3 µm;p < 0.001).DiscussionA greater reduction in the number of smaller particles generated by the EOS device was found for high-speed tooth preparation. Low ΔPN by all AGPs demonstrated the efficacy of high-flow suction.ConclusionsThe additional use of an EOS device should be carefully considered when performing treatments, such as high-speed tooth preparation, that generate particularly small particles when more people are present and all other protective options have been exhausted.
Deciphering the spectral collapse in two-photon Rabi model
Authors: Lo C. F. 
Published: May 2021

AbstractIn this communication, based upon a squeezed-state trial wave function, we have performed a simple variational study of the spectral collapse of the two-photon Rabi model. Our analysis indicates that the light-matter interaction and the spin-flipping effectively constitute two competing impacts upon the radiation mode. Whilst the former tries to decrease the radiation mode frequency, the latter may counteract or reinforce it, contingent upon the state of the atomic system. The light–matter interaction appears to dominate the frequency modulation as its coupling strength goes beyond the critical value, leading to the emergence of the spectral collapse. However, at the critical coupling the dominance of the light–matter interaction is not complete, and incomplete spectral collapse appears. The extent of incomplete spectral collapse is found to depend upon the energy difference between the two atomic levels as well.
Whole transcriptome RNA-seq reveals key regulatory factors involved in type 2 diabetes pathology in peripheral fat of Asian Indians
Authors: Saxena Aditya , Mathur Nitish , Tiwari Pradeep , Mathur Sandeep Kumar 
Published: May 2021

AbstractThe prevalence of Type 2 Diabetes has reached an epidemic proportion particularly in south Asian countries. We have earlier shown that the anatomical fat distribution, termed ‘thin fat phenotype’ in this population indeed plays a major role for their T2D-predisposition it is indeed the sick fat or adiposopathy, which is the root cause of metabolic syndrome and diabetes and affects both—peripheral, as well as visceral adipose tissue compartments. In present study, we have attempted to unravel the altered regulatory mechanisms at the level of transcription factors, and miRNAs those may likely accounts to T2D pathophysiology in femoral subcutaneous adipose tissue. We prioritized transcription factors and protein kinases as likely upstream regulators of obtained differentially expressed genes in this RNA-seq study. An inferred network of these upstream regulators was then derived and the role of TFs and miRNAs in T2D pathophysiology was explored. In conclusions, this RNS-Seq study finds that peripheral subcutaneous adipose tissue among Asian Indians show pathology characterized by altered lipid, glucose and protein metabolism, adipogenesis defect and inflammation. A network of regulatory transcription factors, protein kinases and microRNAs have been imputed which converge on the process of adipogenesis. As the majority of these genes also showed altered expression in diabetics and some of them are also circulatory, therefore they deserve further investigation for potential clinical diagnostic and therapeutic applications.
Esmolol during cardiopulmonary resuscitation reduces neurological injury in a porcine model of cardiac arrest
Authors: Ruggeri Laura , Nespoli Francesca , Ristagno Giuseppe , Fumagalli Francesca , Boccardo Antonio , Olivari Davide , Affatato Roberta , Novelli Deborah , De Giorgio Daria , Romanelli Pierpaolo , Minoli Lucia , Cucino Alberto , Babini Giovanni , Staszewsky Lidia , Zani Davide , Pravettoni Davide , Belloli Angelo , Scanziani Eugenio , Latini Roberto , Magliocca Aurora 
Published: May 2021

AbstractPrimary vasopressor efficacy of epinephrine during cardiopulmonary resuscitation (CPR) is due to its α-adrenergic effects. However, epinephrine plays β1-adrenergic actions, which increasing myocardial oxygen consumption may lead to refractory ventricular fibrillation (VF) and poor outcome. Effects of a single dose of esmolol in addition to epinephrine during CPR were investigated in a porcine model of VF with an underlying acute myocardial infarction. VF was ischemically induced in 16 pigs and left untreated for 12 min. During CPR, animals were randomized to receive epinephrine (30 µg/kg) with either esmolol (0.5 mg/kg) or saline (control). Pigs were then observed up to 96 h. Coronary perfusion pressure increased during CPR in the esmolol group compared to control (47 ± 21 vs. 24 ± 10 mmHg at min 5, p < 0.05). In both groups, 7 animals were successfully resuscitated and 4 survived up to 96 h. No significant differences were observed between groups in the total number of defibrillations delivered prior to final resuscitation. Brain histology demonstrated reductions in cortical neuronal degeneration/necrosis (score 0.3 ± 0.5 vs. 1.3 ± 0.5, p < 0.05) and hippocampal microglial activation (6 ± 3 vs. 22 ± 4%, p < 0.01) in the esmolol group compared to control. Lower circulating levels of neuron specific enolase were measured in esmolol animals compared to controls (2[1–3] vs. 21[16–52] ng/mL, p < 0.01). In this preclinical model, β1-blockade during CPR did not facilitate VF termination but provided neuroprotection.
Basal ganglia and cerebellum contributions to vocal emotion processing as revealed by high-resolution fMRI
Authors: Ceravolo Leonardo , Frühholz Sascha , Pierce Jordan , Grandjean Didier , Péron Julie 
Published: May 2021

AbstractUntil recently, brain networks underlying emotional voice prosody decoding and processing were focused on modulations in primary and secondary auditory, ventral frontal and prefrontal cortices, and the amygdala. Growing interest for a specific role of the basal ganglia and cerebellum was recently brought into the spotlight. In the present study, we aimed at characterizing the role of such subcortical brain regions in vocal emotion processing, at the level of both brain activation and functional and effective connectivity, using high resolution functional magnetic resonance imaging. Variance explained by low-level acoustic parameters (fundamental frequency, voice energy) was also modelled. Wholebrain data revealed expected contributions of the temporal and frontal cortices, basal ganglia and cerebellum to vocal emotion processing, while functional connectivity analyses highlighted correlations between basal ganglia and cerebellum, especially for angry voices. Seed-to-seed and seed-to-voxel effective connectivity revealed direct connections within the basal ganglia—especially between the putamen and external globus pallidus—and between the subthalamic nucleus and the cerebellum. Our results speak in favour of crucial contributions of the basal ganglia, especially the putamen, external globus pallidus and subthalamic nucleus, and several cerebellar lobules and nuclei for an efficient decoding of and response to vocal emotions.
Development the concept of using XML-schemas and requirements for them for the transfer and storage of information, documents and materials included in the information model of capital construction objects
Authors: Chelyshkov Pavel , Volkov Sergey , Babushkin Evgeny , Zueva Diana 
Published: May 2021

The lack of a unified structure of the information model at different stages of the life cycle for different types of capital construction objects and the lack of requirements for the composition and content of the information model causes the problem of transferring the information model of the capital construction object from one stage to another in order to exchange and analyze data on objects throughout the entire life cycle. cycle, which will allow to simultaneously take into account technological, financial, technical parameters and the time factor, maintaining the data in an up-to-date and complete state at any time for all participants in the investment and construction process, including management companies, operating, repair, construction, subcontracting, design and research organizations, supervisory and control bodies.
The goal of this article is to develop a concept for using XML schemas for transferring from one stage of the life cycle to another and storing information, documents and materials included in the information model of capital construction objects.
Status of Sentinel Lymph Node Biopsy in Endometrial Cancer
Authors: Taran Florin Andrei , Jung Lisa , Waldschmidt Julia , Huwer Sarah Isabelle , Juhasz-Böss Ingolf 
Published: May 2021

AbstractThe role of lymphadenectomy in surgical staging remains one of the biggest controversies in the management of endometrial cancer. The concept of sentinel lymph node biopsy in endometrial cancer has been evaluated for a number of years, with promising sensitivity rates and negative predictive values. The possibility of adequate staging while avoiding systematic lymphadenectomy leads to a significant reduction in the rate of peri- and postoperative morbidity. Nevertheless, the status of sentinel lymph node biopsy in endometrial cancer has not yet been fully elucidated and is variously assessed internationally. According to current European guidelines and recommendations, sentinel lymph node biopsy in endometrial cancer should be performed only in the context of clinical studies. In this review article, the developments of the past decade are explored concisely. In addition, current data regarding the technical aspects, accuracy and prognostic relevance of sentinel lymph
node biopsy are explained and evaluated critically.
Akzeptanz von digitalen Gesundheitstechnologien bei leichter bis mittelgradiger Depression – Eine qualitative Analyse aus der Perspektive von Betroffenen, Angehörigen und Leistungserbringern
Authors: Hafner Jessica , Schönfeld Simone , Tokgöz Pinar , Hrynyschyn Robert , Schlubach Arndt , Dockweiler Christoph 
Published: May 2021

Zusammenfassung
Ziel der Studie Die Nutzer*innenakzeptanz von digitalen Gesundheitstechnologien bei leicht- bis mittelgradiger Depression ist bislang rudimentär erforscht und wird in vorliegender Studie untersucht.
Methodik Es wurden problemzentrierte Einzelinterviews mit 3 Betroffenen, 3 Angehörigen und 13 Leistungserbringern (v. a. Medizin, Psychologie, Pflege) durchgeführt und qualitativ ausgewertet.
Ergebnisse Entlang der Unified Theory of Acceptance and Use of Technology wurden Haltungen von Betroffenen, Angehörigen und Leistungserbringern dargestellt. Die Leistungserwartung und unterstützenden Rahmenbedingungen stellen bedeutsame Prädiktoren für die Nutzungsintention dar.
Schlussfolgerung Die Ergebnisse bieten eine Basis, um im Folgeschritt die Kernbedürfnisse und Haltungen zu priorisieren. Im Sinne eines ethischen, nachhaltigen und ökonomischen Einsatzes ist weitere Forschung zur Nutzer*innenakzeptanz notwendig.
Calibration of the energy response matrix for X-ray detector CCD236
Authors: Zhu Y.X. , Lu J.B. , Li X.B. , Liu X.Y. , Cui W.W. , Han D.W. , Wang J. , Wang Y.S. , Zhao X.F. , Zhang S. , Wang G.F. , Chen Y.P. , Yu N. , Chen Y. 
Published: May 2021

Abstract
CCD236 is a new generation swept charge device (SCD) developed by e2v. It is designed for the Low Energy Telescope (LE) onboard the Hard X-ray Modulation Telescope (HXMT). The spectrum of the detector is a convolution result of the incident spectrum and the energy response of the detector. One can obtain accurate quantities of incident spectrum by fitting the model spectrum with the energy response. According to the two-dimensional interpolation method, an energy response matrix of CCD236 is generated using the calibration data obtained by the low X-ray calibration facility located at Institute of High Energy Physics. The accuracy of interpolation is better than 0.2 eV, and the full width at half maximum (FWHM) variation trend with energy of the RSP agrees well with that of the calibration data. After that, a double-gaussian model of Fe-55 source was convoluted with the energy response matrix. The result shows that the fitting residual is controlled within 3σ after considering a systematic error of 0.1%. The deviation of full-energy peak is less than 10 eV. The RSP can well characterize the response of CCD236 detector in the observable energy region.
Modeling and Simulation of Voltage Sag Assessment for Distribution Network Based on Total Coverage of Nodes
Authors: Lu Xiaoli , Yang Dongjunming , Wang Qunfei , Yin Zhongdong 
Published: May 2021

Abstract
The evaluation of voltage sag of power grid is to analyze the situation of voltage sag, to guide the planning, construction and transformation of power grid, and further improve the power quality. It is an important content in the current power quality research. In this paper, the fault point is regarded as a new virtual node, and the fault location is described by fault location parameters λ. The system node impedance matrix is expanded by calculating the self impedance and mutual impedance between the virtual node and the concerned node. Through the modeling and simulation of distribution network, short-circuit faults are set to analyze the voltage sag. According to the three-phase voltage sag waveform recorded by power quality monitoring system (PQMS), the fault type can be identified, and the fault line can be determined according to the PDR of SCADA system. Without considering the fault resistance, the fault type and fault line are known, so the fault location can be found only by solving the fault location parameters λ. Because of its parallel processing and good robustness, particle swarm optimization algorithm can find the optimal solution of the problem with large probability and fast convergence speed, so this paper chooses to use particle swarm optimization algorithm to solve the fault location parameters λ.
Design and test of a 10 kV HV brushing for triaxial HTS cable termination
Authors: Wu Xiaochen , Hu Ziheng , Zhang Bin , Wang Zhenzi , Wang Wei , Wang Zhe , Wang Bangzhu 
Published: May 2021

Abstract
The high voltage (HV) bushing design of insulation core, umbrella skirt, lead type, and production process were proposed according to the technical requirements of the 10 kV high temperature superconducting (HTS) cable system of Shenzhen Power Supply Bureau. The design took full consideration of the withstanding voltage, impulse voltage, partial discharge, thermal shock, and anti-condensation level. According to the proposed design, a verification prototype was built and tested. It subjected to five slow 77 K-300 K thermal shock cycles and five severe 77 K-300 K thermal shock cycles to verify its performance. The sensitive electrical quantities were tested after each cycle. After the 10 cycles, no degradation of performance and no breakdown or flashover occurred were found in the prototype. The results show that the design is qualified for the expected purpose.
Process Simulation of the Influence of Phosphate Rock Impurities on the Production Index of Superphosphate
Authors: Tan Yanxia 
Published: May 2021

Abstract
Through process simulation, the feasibility of the process and the influence of parameter changes on process indicators can be discussed, and guiding and optimizing the production process can be used. The impurities in phosphate rock mainly include components such as calcium carbonate, magnesium carbonate, iron trioxide, aluminum oxide and calcium fluoride, which presence can lead to changes in the production indicators of superphosphate. In this paper, the process simulation method is used to discuss the influence of the main impurity components in the phosphate rock on the production index of superphosphate. The results show that there is a linear relationship between the production index of superphosphate and the impurity coefficient. As the content of each impurity component increases, the effective P2O5 content and free acid P2O5 content of superphosphate products decrease, the free water content increases, the phosphate rock consumption quota decreases, and the sulfuric acid consumption quota increases. Among them, Al2O3 has the greatest impact on the product’s effective P2O5 content and free water content, CaF2 has the greatest impact on the product’s free acid P2O5 content and phosphate rock consumption quota, and MgCO3 has the greatest impact on the sulfuric acid consumption quota. The cumulative effect of various impurities on production indicators has a superimposing effect.
Application of Environment-perception Intelligent Control Technology in the Inspection Robot of Coal Conveyance Corridor in Thermal Power Plant
Authors: Jia Xiaoping , Yuan Wenjie , Li Haichao , Jiang Shanqiu , Zhang Yude 
Published: May 2021

Abstract
In thermal power generation, coal transport is an important link in the production process, and corridor is the key space of a relatively closed environment. It is fatal to ensure the accurate transmission of coal, no coal leakage and scattering, timely maintenance of the belt with crack, keep the temperature, humidity, and dust concentration within the threshold. Traditionally, manual inspection is mostly used, which is difficult to meet the requirements of modern thermal coal transportation inspection due to large amount of labor and high intensity of labor. According to the performance requirements, operating mode, and function in space orbit, an inspection robot is proposed, replacing the manual labor, by use of machine vision, sensor technology, logic judgment algorithm, and combined with kinematics and dynamics analysis. The modular design of hanging rail type mobile robot system is carried out in layout with closed “O” type suspension orbit in the inspection area, realizing the robot’s inspection and monitoring, warning and prompting, for the safety and smoothness of the coal supply.
The role of artificial intelligence recognition in metallogenic prediction
Authors: Pei Yao 
Published: May 2021

Abstract
Artificial intelligence algorithm has developed rapidly in recent years, and deep learning has become the research hotspot of many scholars. Artificial intelligence algorithm is just developing in geology, especially in metallogenic prediction. In this work, the 1:250000 aeromagnetic data image of a certain area is used to predict the gold deposit, and good research results are obtained.
Phytoplankton dynamics at a reservoir in northeast China
Authors: Ashour Mohammed F. Y. , Guan Di , Zheng Guochen 
Published: May 2021

Abstract
This study assessed the impact of water quality parameters on phytoplankton in the various spatial and seasonal scales of the Nierji reservoir. The research data covered three sites along the mainstream of the Nierji reservoir which is located in the northeast China. The seasonal and spatial variations were the essential factors regulating phytoplankton dynamics. Dominant influencing factors of the chlorophyll-a (Chl-a) content of phytoplankton were different according to the spatial and seasonal scales. Although total phosphorus was the limiting factor influencing the phytoplankton in the various spatial and seasonal scales, Chl-a was weakly correlated to total phosphorus in the upstream, midstream, and downstream during the flood season. A weak correlation between Chl-a and total nitrogen was found when ammonia nitrogen or nitrate displayed a stronger correlation with Chl-a. Ammonia nitrogen or nitrate was significantly correlated to total nitrogen when the correlation between Chl-a and total nitrogen was not significant. The Chl-a increased with decreasing the Secchi depth in the reservoir.