bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mid-Term Outcome of Mitral Valve Replacement During Septal Myectomy for Hypertrophic Obstructive Cardiomyopathy
Authors: Chun Hon , Mei Bo , Chen Guang-xian , Feng Kang-ni , Liang Meng-ya , Wu Zhong-kai 
Published: May 2021

Abstract
Background

The mitral valve shows significant involvement in hypertrophic obstructive cardiomyopathy (HOCM). The mid-term outcomes of management of HOCM by prosthetic valve replacement with septal myectomy remain unclear. This study compared the prognosis of patients with and without prosthetic valve replacement.
Methods

From 01/2009 until 10/2015, 24 patients with HOCM underwent septal myectomy with or without valve repair/replacement were recruited. A total of 23 patients underwent echocardiographic evaluation before and after the operation. The follow-up duration ranged from 0.4 to 7 years (median 2.5 years). The Kaplan-Meier test was used to explore the association between prosthetic valve replacement and overall/disease-free survival among HOCM patients.
Results

A total of 9 patients underwent septal myectomy with/without mitral valve repair (MVr), and the other 15 patients underwent septal myectomy with mitral valve replacement (MVR). Six patients treated with MVR had unfavorable outcomes, including one peri-operative and three late deaths; one patient suffered from aborted sudden death, and one patient was treated for prosthetic valve endocarditis. Prosthetic valve replacement was associated with poor disease-free survival (p = 0.025).
Conclusions

Septal myectomy with or without-MVr was associated with a better outcome than septal myectomy with MVR in HOCM patients. The differences in prognosis were caused by more complicated left ventricular outflow tract structures and more prosthetic valve complications among patients undergoing MVR.
Vaginal Microbiota Characteristics of Pregnancy of Unknown Location Women in China(VMCPULW): Study Protocol for a Prospective Cohort
Authors: Huang Xuge , Zhang Yingxuan , Wang Dongying , Zhang Huimin , Chen Si , Chen Xiaofeng , Guo Yinan , Li Sijin , Huang Yanxi , Luo Songping , Gao Jie 
Published: May 2021

Abstract
Background: Pregnancy of unknown location (PUL) is a kind of pregnancy that has a positive beta-human chorionic gonadotropin (β-hCG) test result but the location of pregnancy cannot be determined by ultrasound. Early determination of the location of the pregnancy is important for subsequent treatment. However, there is no study on the characteristics of vaginal microbiota in pregnant women with unknown locations and a model for judging it by vaginal microbiota combined with clinical indicators. Therefore, we designed this study to compare the characteristics of vaginal microbiota in intrauterine and ectopic pregnancy populations during pregnancy with unknown locations and to establish a prediction model for pregnancy locations in PUL populations with clinical indicators.Methods: This is a prospective, multicenter cohort study. 576 eligible participants will be included in this study. Vaginal microbiota was collected from all participants at inclusion, and color Doppler ultrasound was performed weekly. After the locations of pregnancy were determined, participants of intrauterine pregnancy were followed up to their early pregnancy outcome, and participants of ectopic pregnancy were followed up until a none-pregnancy level of β-hCG was confirmed. Discussion: The regular method of judging the location of pregnancy is by color Doppler ultrasound and β-hCG test. We hope to provide earlier clinical methods of prediction for women with unknown locations of pregnancy through this study.Trial registration: Chinese Clinical Trial Registry: ChiCTR2000035378, registration date: 9 August 2020. http://www.chictr.org.cn/index.aspx
Impact of treatment dose on patient outcomes after Interdisciplinary Multimodal Pain Therapy
Authors: Baumbach Philipp , Richter Maria , Schneider Johannes , Smolenski Ulrich Christian , Weiss Thomas , Meissner Winfried 
Published: May 2021

Abstract
Objectives The impact of duration and intensity on outcomes after Interdisciplinary Multimodal Pain Therapy (IMPT) is poorly researched. The aim of this study was to compare the effects of low dose (LD, avg. 25 hours) and high dose IMPT (HD, avg. 110 hours).Methods Patients completed pain-related questionnaires at the beginning (T1), at the end of therapy (T2) and at 3-month follow-up (T3) and were matched according to age, sex, presence of back-pain and pain-related disability at T1, resulting in 32 patients per group. Primary endpoint was the difference in pain-related disability and average pain intensity at T3 between both groups. In addition, early treatment effects and group differences at T2 were analyzed.Results Both groups showed significant improvements in pain-related disability and average pain intensity between T1 and T2. These positive effects persisted in the HD group until the 3-month follow-up, whereas outcomes in the LD group patients deteriorated and were significantly poorer compared to HD at T3.Discussion Within a widely comparable therapeutic setting, high-dose IMPT was associated with longer lasting improvements compared to low-dose IMPT in chronic pain patients, indicating that the “dose” of therapy is a relevant factor for clinical outcomes and should be further investigated.
Clinical Comparison Between Thoracoscopic and Thoracotomy Repair of Gross Type C Esophageal Atresia
Authors: Yang Shen , Wang Peize , Yang Zhi , Li Siqi , Liao Junmin , Hua Kaiyun , Zhang Yanan , Zhao Yong , Gu Yichao , Li Shuangshuang , Chen Yongwei , Huang Jinshi 
Published: May 2021

Abstract
Background
To compare the clinical outcomes between thoracoscopic approach and thoracotomy surgery in patients with Gross type C Esophageal atresia (EA) and tracheoesophageal fistula (TEF).
Methods
Patients with Gross type C EA/TEF who underwent surgery from January 2007 to January 2020 at Beijing Children’s Hospital were retrospectively analyzed. The patients were divided into 2 groups according to surgical approaches. The perioperative factors and postoperative complications were compared among the 2 groups.
Results
One hundred and ninety patients (132 boys and 58 girls) with a median birth weight of 2975 (2600, 3200) g were included. The primary operations were performed via thoracoscopic (n = 62) and thoracotomy (n = 128) approach. After comparison of clinical characteristics between the 2 groups, we found that there were statistically significant differences in associated anomalies, method of fistula closure, duration of mechanical ventilation after surgery, feeding option before discharge, management of pneumothorax, and prognosis (all P < 0.05). To a certain extent, thoracoscopic surgery reduced the incidence of anastomotic leakage and increased the incidence of anastomotic stricture in this study. However, there were no statistically significant differences between the 2 groups in terms of operative time, postoperative pneumothorax, anastomotic leakage, anastomotic stricture, and recurrent tracheoesophageal fistula (all P > 0.05).
Conclusions
Thoracoscopy surgery for Gross type C EA/TEF is a safe and effective, minimally invasive technique with comparable operative time and incidence of postoperative complications.
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes
Authors: Verba Kliment , Gupta Meghna , Azumaya Caleigh , Moritz Michelle , Pourmal Sergei , Diallo Amy , Merz Gregory , Jang Gwendolyn , Bouhaddou Mehdi , Fossati Andrea , Brilot Axel , Diwanji Devan , Hernandez Evelyn , Herrera Nadia , Kratochvil Huong , Lam Victor , Li Fei , Li Yang , Nguyen Henry , Nowotny Carlos , Owens Tristan , Peters Jessica , Rizo Alexandrea , Schulze-Gahmen Ursula , Smith Amber , Young Iris , Yu Zanlin , Asarnow Daniel , Billesbølle Christian , Campbell Melody , Chen Jen , Chen Kuei-Ho , Chio Un Seng , Dickinson Miles , Doan Loan , Jin Mingliang , Kim Kate , Li Junrui , Li Yen-Li , Linossi Edmond , Liu Yanxin , Lo Megan , Lopez Jocelyne , Lopez Kyle , Mancino Adamo , III Frank Moss , Paul Michael , Pawar Komal , Pelin Adrian , Pospiech Thomas , Puchades Cristina , Remesh Soumya , Safari Maliheh , Schaefer Kaitlin , Sun Ming , Tabios Mariano , Thwin Aye , Titus Erron , Trenker Raphael , Tse Eric , Tsui Tsz Kin Martin , Feng Feng , Zhang Kaihua , Zhang Yang , Zhao Jianhua , Zhou Fengbo , Zhou Yuan , Zuliani-Alvarez Lorena , Agard David , Cheng Yifan , Fraser James , Jura Natalia , Kortemme Tanja , Manglik Aashish , Southworth Daniel , Stroud Robert , Swaney Danielle , Krogan Nevan , Frost Adam , Rosenberg Oren 
Published: May 2021

Abstract
The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but its exact functions, and the structural basis of those functions, remain unknown. Here, we report an atomic model for full-length Nsp2 obtained by combining cryo-electron microscopy with deep learning-based structure prediction from AlphaFold2. The resulting structure reveals a highly-conserved zinc ion-binding site, suggesting a role for Nsp2 in RNA binding. Mapping emerging mutations from variants of SARS-CoV-2 on the resulting structure shows potential host-Nsp2 interaction regions. Using structural analysis together with affinity tagged purification mass spectrometry experiments, we identify Nsp2 mutants that are unable to interact with the actin-nucleation-promoting WASH protein complex or with GIGYF2, an inhibitor of translation initiation and modulator of ribosome-associated quality control. Our work suggests a potential role of Nsp2 in linking viral transcription within the viral replication-transcription complexes (RTC) to the translation initiation of the viral message. Collectively, the structure reported here, combined with mutant interaction mapping, provides a foundation for functional studies of this evolutionary conserved coronavirus protein and may assist future drug design.
Prevalence of Relapse of Alcohol Use Disorder and the Association With Self-Efficacy and Perceived Social Support in Butabika Hospital
Authors: Kalani Kenneth , Nakigudde Janet , Birungi Caroline , Onoria Joy Gumikiriza- , Mukiza Nelson , Arinda Anita , Luwedde Betijuma , Irimaso Hillary 
Published: May 2021

Abstract
Background

Alcohol use disorder (AUD) is a problem globally and Uganda has one of the highest per capita alcohol consumption rates in sub-Saharan Africa. Relapse is a distressing aspect in the treatment of AUD and it is mediated by self-efficacy and perceived social support besides other psychosocial factors. In Uganda, there is paucity of data regarding relapse of AUD and the association with self-efficacy and perceived social support hence the need to carry out this study.
Objective

To determine the prevalence of relapse of AUD and the association with self-efficacy and perceived social support at Butabika hospital.
Methods

A cross-sectional study design was used and 269 participants that received treatment for AUD at hospital in the period between 1st /01/2016 and 31st /12/2017 were consecutively recruited. Participants were assessed for relapse of AUD using the SCID-5 substance use disorder section. Data was collected using a socio-demographic questionnaire, the general self-efficacy scale and the multidimensional scale for perceived social support. Data was entered in Epidata 3.0 and imported into STATA version 14 for analysis. Chi square test and logistic regression were used at bi-variable and multivariable analysis respectively to determine associations.
Results

The prevalence of relapse of AUD among the 269 participants was 63.3% (170). Of those who relapsed, 98% (167) had severe AUD. Participants with a marital status of single were less likely to relapse into alcohol use than those with a marital status of; separated or divorced (OR = 6.81; 95% CI = 1.53–30.32; p-value = 0.012) and married (OR = 2.86; 95% CI = 1.07–7.65; p-value = 0.037). Male participants were more likely to relapse into AUD than the females (OR = 0.19; 95%CI = 0.04–0.86; p-value = 0.03). Participants with higher perceived social support (OR = 0.85; 95% CI = 0.81–0.9; p-value = < 0.001) were less likely to relapse into AUD. Self-efficacy (OR = 0.93; 95% CI = 0.85-1; p-value = 0.061) was not significantly associated with relapse of AUD.
Conclusion

The prevalence of relapse of AUD is high and is associated with perceived social support, marital status of; separated, divorced or married, and female gender. Relapse prevention programs should emphasize the importance of social support in the management of patients with AUD. Further research to assess the relationship between relapse of AUD among married people is recommended.
Effects of Continuous Cropping of Lilium Lancifolium on Rhizosphere Soil Physical and Chemical Properties and Fungal Community Structure
Authors: Huang Shixia , Lin Lihao , Zhao Tianyu , Yuan Yi , Tai Yuling , Ye Aihua 
Published: May 2021

Abstract
Lilium lancifolium is an important economic crop in Huoshan county of Anhui province, China. Continuous cropping obstacles serious affect the yield and quality of L. lancifolium. At present, the effect of the continuous cropping of L. lancifolium on soil fungal community structure is not clear. In this study, Illumina MiSeq was used to study the fungi of the rhizosphere soil associated with L. lancifolium subjected to three treatments: no continuous cropping, continuous cropping for 3 years, and continuous cropping for 5 years. The results showed that continuous cropping of L. lancifolium could increase the fungal richness and diversity in the rhizosphere to different degrees. Ascomycota was the dominant phylum, and its abundance increased after continuous cropping. In addition, the abundance of beneficial fungi, such as Chaetomium, decreased, and the abundance of harmful fungi, such as Fusarium and Colletotrichum, greatly increased with the duration of continuous cropping. Overall, continuous cropping changed the composition of soil fungal communities, reduced the abundance of beneficial fungi, and increased the abundance of harmful fungi. Thus, continuous cropping increased the potential for soil-borne diseases and endangered the bulb growth of L. lancifolium.
Quality of Family Planning Care as Enabling Factor for Modern Contraceptive Use in Indonesia: Evidence from PMA2020 Survey
Authors: Nurjaeni Nurjaeni , Sawangdee Yothin , Pattaravanich Umaporn , Holumyong Charamporn , Chamratrithirong Aphichat 
Published: May 2021

Abstract
BackgroundThe utilization of modern family planning methods is a key pointer that mirrors universal access to reproductive health cares. Fulfilling unmet needs for modern contraceptives may decrease the level of maternal mortality by almost a third. This research employed the 2016 PMA2020 survey to assess multilevel variables related to modern family planning method use among women of reproductive age in Indonesia. MethodData from interviews of female and Service Delivery Point (SDP) of the 2016 Performance Monitoring and Accountability 2020 (PMA2020) survey were linked to generate a merged dataset comprising women’s individual, cluster and SDP factors (N=10,210). Multilevel analysis was done to assess the influence of contextual factors including a summary index of SDP quality FP care on woman’s modern family planning practice. Adjusted odds ratios and 95% CIs were analysed and interpreted.ResultsModern contraceptive prevalence among women of childbearing age was 42.3% in 2016. There was a considerable variation in the likelihood of modern method use across the 372 clusters/EAs. Age, education, marital status, parity, residency, region, woman’s FP decision autonomy, cluster’s average ideal number of children, percentage of females dissatisfied with FP, and percent of females visited by CHVs were significant factors for modern FP use after adjusting for multilevel characteristics. Quality of FP care was revealed to be a significant enabling factor for modern contraceptive use in Indonesia. ConclusionsModern contraceptive prevalence among females aged 15-49 years was relatively low in 2016. The findings indicate that an advancement in modern method use can be gained by improving quality of family planning care. Likewise, an enhancement in women’s FP decision autonomy and their level of education, decline in women’s ideal number of children and diminution of the dissatisfaction with family planning are all major concerns to be addressed. Family planning policies must tackle adverse cultural norms and inequities in quality of family planning care and women’s education that would produce welfares to women, children, and communities.
Flat-floor Bubbles, Dark Solitons, and Vortices Stabilized by Inhomogeneous Nonlinear Media
Authors: Zeng Liangwei , Malomed Boris A. , Mihalache Dumitru , Cai Yi , Lu Xiaowei , Zhu Qifan , Li Jingzhen 
Published: May 2021

Abstract
We consider one- and two-dimensional (1D and 2D) optical or matter-wave media with a maximum of the local self-repulsion strength at the center, and a minimum at periphery. If the central area is broad enough, it supports ground states in the form of flat-floor “bubbles”, and topological excitations, in the form of dark solitons in 1D and vortices with winding number m in 2D. The ground and excited states are accurately approximated by the Thomas-Fermi expressions. The 1D and 2D bubbles, as well as vortices with m=1, are completely stable, while the dark solitons and vortices with m=2 have nontrivial stability boundaries in their existence areas. Unstable dark solitons are expelled to the periphery, while unstable double vortices split in rotating pairs of unitary ones. Displaced stable vortices precess around the central point.
Capacity-Building and Continuing Professional Development in Healthcare and Rehabilitation in Low- and Middle-Income Countries - A Scoping Review Protocol
Authors: Deprez Dalton , Busch Angela J , Ramirez Paola Andrea , Araque Eliany Eliany Pedrozo , Bidonde Julia 
Published: May 2021

Abstract
Background: A recent world health report suggests that there is a growing rehabilitation human resource crisis. This review focuses on capacity-building needed to meet present and future rehabilitation challenges in low- and middle-income countries (LMICs). Capacity building is the process by which individuals and organizations obtain, improve, and retain the skills, knowledge, tools, equipment, and other resources needed to do their jobs competently. The objectives of this review are; 1) to determine how capacity-building has been defined, implemented, and evaluated in LMICs; and 2) to provide an overview of the effectiveness of capacity-building initiatives.Methods: In the first of seven stages, we will refine and delimit the research. Then, we will identify relevant studies by searching five biomedical databases, two rehabilitation databases, three regional databases, and three databases of grey literature. Two independent reviewers will then select the studies using a priori selection criteria. We will exclude incomplete records, records published prior to 2000 for databases and 2010 for grey literature, and records written in languages other than English or Spanish. We will also exclude records focusing on entry-to-practice programs in academic settings. For Objective 1, using qualitative analysis software we will extract and analyze text from included records which defines or explains capacity building. For Objective 2, using an online file sharing platform, one reviewer will extract data describing the effectiveness of capacity building interventions and a second reviewer will verify accuracy, with disagreements resolved by consensus. The results will be collated using tables and charts. After synthesizing the results, we will discuss the practicality and applicability of findings with partners from Honduras and Colombia. We will use several formats and venues including presentations and publications in English and Spanish to present our results.Discussion: To our knowledge, this will be the first attempt to systematically identify knowledge of capacity-building and rehabilitation in LMICs. This scoping review results will offer unique insights concerning the breadth and depth of literature in the area. It is anticipated that results from this scoping review will guide efforts in future capacity-building efforts in rehabilitation in LMICsReview Registration: Busch AJ, Deprez D, Bidonde J, Ramírez PA, Araque EP. Capacity building and continuing professional development in healthcare and rehabilitation in low and middle income countries - A scoping review. 2021. doi:10.17605/OSF.IO/7VGXU.
Exposure to the COVID-19 News on Social Media: Psychological and Self-reported Behavioural Responses Among Iranian Adults
Authors: Mokhtari-Hesari Parisa , Yarmohammadi Hossein , Bahabadi Mehdi Rafiei ,   Fatemeh Naghizadeh Moghari1 Fatemeh Naghizadeh Moghari1, Maftoon Farzaneh , Tavousi Mahmoud , Riazi Hedyeh , Montazeri Ali 
Published: May 2021

Abstract

Background: Exposure to news on coronavirus disease 2019 (COVID-19) pandemic is inevitable. This study aimed to explore associations between exposure to COVID-19 news on social media and psychological and behavioral consequences among Iranians.Methods: This was a telephone-based survey carried out in April 2020 in Iran. Iranian adults aged 18 and over were randomly selected from the postal codes and using their mobile phones. A self-designed questionnaire was administered to collect data on participants’ characteristics and questions to address their psychological and behavioral responses regarding the COVID-19 pandemic. A multivariate logistic regression model was performed to assess the relationship between anxiety, fear, and behavioral responses and independent variables including exposure to news.Results: In all 1563 adults participated in the study. The mean age of respondents was 39.17±13.5 years. Moderate to high-level anxiety was reported by 55.4% of participants, while fear of being affected by coronavirus was reported by 54.1%. Overall 88% reported that they changed their behaviors to some extent. Exposure to the COVID-19 news on social media was by far the most influencing variable on anxiety (OR= 2.21, 95% CI: 1.62-3.04; P < 0.0001), fear (OR = 1.95, 95% CI: 1.49-2.56; P < 0.0001), and change in health behaviors (OR = 2.02, 95% CI: 1.28-3.19; P = 0.003) in the regression model. While independent variables did not show significant associations with anxiety and behavior change, the fear of being infected by the COVID19 was associated with the female gender and some socio-economic characteristics of the participants.Conclusion: Although exposure to the COVID-19 news on social media seemed to be associated with excessive anxiety and fear among people, it also, to some extent, positively has changed people’s health behaviors towards preventive measures.