bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of exercise on pain perception in women with endometriosis: A systematic review
Authors: Hansen Sara , Sverrisdóttir Una Á. , Rudnicki Martin 
Published: May 2021

AbstractIntroductionEndometriosis is challenging to treat. It is a painful and chronic inflammatory disorder that impacts up to 10% of women of reproductive age. Despite available surgical and medical treatment options, recurrence of symptoms is common. Available studies suggest that exercise may have a therapeutic effect on chronic inflammation and thereby on pain perception. This review evaluates whether exercise can decrease pain perception in women with symptomatic endometriosis.Material and methodsThis systematic review was conducted according to PRISMA by searching databases Medline and Embase to locate randomized controlled trials and observational studies. Risk of bias was investigated using the Cochrane Collaboration Tool for the Evaluation of Randomized Controlled Trials and the ROBINS‐I quality assessment scale. Inclusion criteria were women of reproductive age, laparoscopically confirmed diagnosis of endometriosis, and intervention of any type of exercise. All manuscripts were evaluated by two of the authors and when in doubt a third author was consulted. This review was registered in PROSPERO on November 14, 2020 (CRD42020212309).ResultsSix articles fulfilled the inclusion criteria and were included in this systematic review. Concerning exercise, two studies showed significant decrease in pain relief but the remaining studies showed either negative or no impact on pain relief. A meta‐analysis could not be conducted because of the considerable heterogeneity among the included studies.ConclusionsThe present review does not indicate any beneficial effect of exercise on pain in women with endometriosis. There is a need for randomized controlled trials with correct power calculation, well‐defined study groups and training programs to be able to answer the question of whether exercise can improve the pain experience in patients with endometriosis.
Clinical value of early viscoelastometric point‐of‐care testing during postpartum hemorrhage for the prediction of severity of bleeding: A multicenter prospective cohort study in the Netherlands
Authors: Ramler Paul I. , Gillissen Ada , Henriquez Dacia D. C. A. , Caram‐Deelder Camila , Markovski Alexander A. , de Maat Moniek P. M. , Duvekot Johannes J. , Eikenboom Jeroen C. J. , Bloemenkamp Kitty W. M. , van Lith Jan M. M. , van den Akker Thomas , van der Bom Johanna G 
Published: May 2021

AbstractIntroductionTo evaluate rotational fibrin‐based thromboelastometry (ROTEM® FIBTEM) with amplitude of clot firmness at 5 min (A5) as an early point‐of‐care parameter for predicting progression to severe postpartum hemorrhage, and compare its predictive value with that of fibrinogen.Material and methodsProspective cohort study in the Netherlands including women with 800–1500 ml of blood loss within 24 h following birth. Blood loss was quantitatively measured by weighing blood‐soaked items and using a fluid collector bag in the operating room. Both FIBTEM A5 values and fibrinogen concentrations (Clauss method) were measured between 800 and 1500 ml of blood loss. Predictive accuracy of both biomarkers for the progression to severe postpartum hemorrhage was measured by area under the receiver operating curves (AUC). Severe postpartum hemorrhage was defined as a composite endpoint of (1) total blood loss >2000 ml, (2) transfusion of ≥4 packed cells, and/or (3) need for an invasive intervention to cease bleeding.ResultsOf the 391 women included, 72 (18%) developed severe postpartum hemorrhage. Median (IQR) volume of blood loss at blood sampling was 1100 ml (1000–1300) with a median (interquartile range [IQR]) fibrinogen concentration of 3.9 g/L (3.4–4.6) and FIBTEM A5 value of 17 mm (13–20). The AUC for progression to severe postpartum hemorrhage was 0.53 (95% confidence interval [CI] 0.46–0.61) for FIBTEM A5 and 0.58 (95% CI 0.50–0.65) for fibrinogen. Positive predictive values for progression to severe postpartum hemorrhage for FIBTEM A5 ≤12 mm was 22.5% (95% CI 14–33) and 50% (95% CI 25–75) for fibrinogen ≤2 g/L.ConclusionsThe predictive value of FIBTEM A5 compared to fibrinogen concentrations measured between 800 and 1500 ml of blood loss following childbirth was poor to discriminate between women with and without progression towards severe postpartum hemorrhage.
Epiretinal large disc of blue‐stained lyophilized amniotic membrane to treat complex macular holes: a 1‐year follow‐up
Authors: Garcin Thibaud , Gain Philippe , Thuret Gilles 
Published: May 2021

AbstractPurposeTo report the long‐term outcomes of large diameter epiretinal lyophilized amniotic membranes (lAMs) in recurrent or persistent macular holes (MHs) with or without rhegmatogenous retinal detachment (RRD), in a prospective interventional case series.MethodsTen eyes of 10 patients underwent pars plana vitrectomy for MH‐associated RRD (n = 5) or persistent MH without RRD (n = 5), in a university Hospital. A 3 or 4 mm diameter disc of lAM, stained with 0.06% trypan blue, was inserted with a catheter through a sclerotomy and positioned over the MH. Gas or silicone‐oil tamponade was used. At 1 year, the main outcome was anatomic success defined as complete MH closure. Secondary outcomes were best corrected visual acuity (BCVA) recovery, changes in ellipsoid zone (EZ) and external limiting membrane (ELM) defects, complications. Mean follow‐up was 13.8 ± 2.9 months (range, 12–18).ResultsMean baseline data were minimum and maximum diameters, respectively, 945 ± 330 and 1507 ± 717 μm; axial length 26.58 ± 3.38 mm; and number of prior surgeries 1.4 ± 0.96. At 1 year, anatomic success was achieved in eight eyes (80%), and two had reduced diameter of MH. All RRDs were reattached without recurrence. Mean logMAR BCVA improved from 1.92 ± 0.58 to 1.17 ± 0.57 (p < 0.001), with nine eyes (90%) achieving ≥0.3 logMAR improvement. Mean EZ and ELM defects decreased (p = 0.004, p = 0.003, respectively). Postoperative complications were RRD (n = 1) reattached by subsequent surgery, lAM slightly retracted under silicone (n = 1), foveal atrophy after early lAM displacement (n = 1).ConclusionA 1‐year follow‐up highlighted that epiretinal large discs of blue‐stained lAM can help safely close refractory MHs, and provide satisfactory visual recovery.
Inertia of negative emotions at work: Correlates of inflexible emotion dynamics in the workplace*
Authors: De Longis Evelina , Alessandri Guido , Sonnentag Sabine , Kuppens Peter 
Published: May 2021

AbstractEmotional inertia is a central feature of emotion dynamics and it refers to the degree to which emotional states are self‐predictive and linger over time, describing their resistance to change. It is related to several indicators of maladjustment, yet there is limited research on its correlates in the workplace, where it may be particularly relevant as emotional experiences deeply influence organizational life. In two experience‐sampling studies, we studied temporal dependency of negative emotional states at work in terms of emotional inertia. In a first study (n = 128), we investigated the association between exhaustion, the core dimension of burnout, with inertia of negative emotions. In a second study (n = 116), we aimed to replicate findings from the first study and additionally examined the moderating role of inertia of negative emotions in the relationship between negative emotions at work and counterproductive work behaviour. The findings show that exhaustion is consistently associated with inertia of negative emotions, and that inertia of negative emotions aggravates the relation between negative emotions and workers' counterproductive work behaviour.
GATA zinc finger domain‐containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β‐thalassaemia through impaired formation of methyl‐binding domain protein 2 (MBD2)‐containing nucleosome remodelling and deacetylation (NuRD) complex
Authors: Liang Yunhao , Zhang Xinhua , Liu Yongqiong , Wang Liren , Ye Yuhua , Tan Xuemei , Pu Jiajie , Zhang Qianqian , Bao Xiuqin , Wei Xiaofeng , Li Dongzhi , Kurita Ryo , Nakamura Yukio , Li Dali , Xu Xiangmin 
Published: May 2021

SummaryReactivation of fetal haemoglobin (HbF) expression is an effective way to treat β‐thalassaemia and sickle cell anaemia. In the present study, we identified a novel GATA zinc finger domain‐containing protein 2A (GATAD2A) mutation, which contributed to the elevation of HbF and ameliorated clinical severity in a patient with β‐thalassaemia, by targeted next‐generation sequencing. Knockout of GATAD2A led to a significant induction of HbF in both human umbilical cord blood‐derived erythroid progenitor‐2 (HUDEP‐2) and human cluster of differentiation (CD)34+ cells with a detectable impact on erythroid differentiation. Furthermore, heterozygous knockout of GATAD2A impaired recruitment of chromodomain helicase DNA‐binding protein 4 (CHD4) to the methyl‐binding domain protein 2 (MBD2)‐containing nucleosome remodelling and deacetylation (NuRD) complex. Our present data suggest that mutations causing the haploinsufficiency of GATAD2A might contribute to amelioration of clinical severity in patients with β‐thalassaemia.
Um Compasso Para Aprender: A Randomized Trial of a Social‐Emotional Learning Program in Homicide‐Affected Communities in Brazil
Authors: McCoy Dana C. , Hanno Emily C. , Ponczek Vladimir , Pinto Cristine , Fonseca Gabriela , Marchi Natália 
Published: May 2021

Despite global demand, the large‐scale effects of social‐emotional learning (SEL) programming in developing countries remain underexplored. Using a randomized control trial, this study examined the effectiveness of a school‐wide SEL intervention—Programa Compasso (PC)—among 3,018 sociodemographically diverse, Portuguese‐speaking children (Mage = 9.85 years) attending 90 public primary schools across Rio de Janeiro, Brazil in 2017. Average impacts of PC on children’s executive function, emotion knowledge, and behavior problems after one school year were null. Moderation analyses did, however, reveal evidence for positive impacts of PC on children’s labeling of emotional expressions and inhibitory control within low‐homicide communities (d = 0.15 SDs), and null effects on these same outcomes in high‐violence areas. Implementation and cultural considerations are discussed.
Sexual dysfunction and activity avoidance in female kidney transplant patients
Authors: Xiao Panpan , Liu Min , Cui Lina , Ding Siqing , Xie Jianfei , Cheng Andy SK 
Published: May 2021

AbstractSexual dysfunction is common after kidney transplantation and has an adverse effect on patients’ quality of life. This paper aims to evaluate the female sexual function, activity avoidance, and kidney function among a convenience sample of patients who had a kidney transplant. A cross‐sectional study was conducted that included 250 patients had undergone a kidney transplant procedure >3 months ago, from multiple transplant centers and answered a self‐reported sociodemographic questionnaire, the female version of the Arizona Sexual Experience Scale, and the Tampa Scale for Kinesiophobia‐13. A correlation was found between sexual function and activity avoidance (r = .361, p < .001, n = 250) as well as between activity avoidance and kidney function (r = .198, p = .012, n = 250). Less education, having no child, post‐transplant time for <36 months, and smoking (active and passive) were risk factors for female sexual dysfunction after kidney transplantation. The results suggest that physicians that the importance of recognize the relationship between fear of sexual activity and sexual function and that they should provide patients with more education and guidance on post‐transplant sexual behaviors.
Reproductive justice: Non‐interference or non‐domination?
Authors: Bhakuni Himani 
Published: May 2021

AbstractThe reproductive justice movement started by black women’s rights activists made its way into the academic literature as an intersectional approach to women’s reproductive autonomy. While there are many scholars who now employ the term ‘reproductive justice’ in their research, few have taken up the task of explaining what ‘justice’ entails in reproductive justice. In this paper I take up part of this work and attempt to clarify the relevant kind of freedom an adequate theory of reproductive justice would postulate. To do so, I compare two approaches to reproductive freedom: an approach based on freedom as non‐interference and an approach based on freedom as non‐domination. I then argue that the non‐domination approach better fits the ideals of the reproductive justice movement as set forth by its founders and should be treated as one of the necessary conditions in any non‐ideal account of reproductive justice. Towards the end, I single out epistemic non‐domination as crucial in shaping the narrative around reproductive justice.
Surgery versus botulinum neurotoxin A to reduce drooling and improve daily life for children with neurodevelopmental disabilities: a randomized controlled trial
Authors: Bekkers Stijn , Pruijn Ineke M J , van der Burg Jan J W , van Hulst Karen , Kok Saskia E , Delsing Corinne P , Scheffer Arthur R T , van den Hoogen Frank J A 
Published: May 2021

AimTo compare the effect of bilateral submandibular duct ligation and botulinum neurotoxin A (BoNT‐A) on drooling severity and its impact on daily life and care in children and adolescents with moderate‐to‐severe drooling.MethodThis was a randomized, interventional, controlled trial in which 53 children and adolescents (31 males, 22 females, mean age 11y, range 8–22y, SD 2y 10mo) with cerebral palsy (58.5%) or other non‐progressive developmental disorders (41.5%) were randomized to BoNT‐A (n=26) or bilateral submandibular duct ligation (n=27). A parent questionnaire on the severity of drooling in specific positions and daily activities and the impact of drooling on daily life and care was filled out at baseline and 8 and 32 weeks posttreatment.ResultsBoth BoNT‐A and bilateral submandibular duct ligation had a positive effect on daily care, damage to electronic equipment and/or furniture, social interactions, and self‐esteem. However, bilateral submandibular duct ligation had a significant greater and longer‐lasting short‐ (8wks) and medium‐term (32wks) effect on daily care, reducing damage to electronic devices, and improving social interactions and satisfaction with life in general.InterpretationThis randomized controlled trial confirms reduced drooling by both BoNT‐A and bilateral submandibular duct ligation, but provides new evidence on improved well‐being through a reduction in drooling. Even though there is a greater risk of complications and morbidity after bilateral submandibular duct ligation, compared to BoNT‐A there was a significantly greater and longer‐lasting positive effect on most outcomes.
What this paper adds

Bilateral botulinum neurotoxin A (BoNT‐A) and submandibular duct ligation had a positive effect on the well‐being of individuals with moderate‐to‐severe drooling.

Bilateral submandibular duct ligation had a greater effect on the impact of drooling during daily care than BoNT‐A.

Bilateral submandibular duct ligation reduced damage to electronic devices and improved social interactions and satisfaction with life.
Diastolic function assessed with speckle tracking over a decade and its prognostic value: The Copenhagen City Heart Study
Authors: Skaarup Kristoffer Grundtvig , Lassen Mats Christian Højbjerg , Marott Jacob Louis , Biering‐Sørensen Sofie R. , Johansen Niklas Dyrby , Modin Daniel , Jørgensen Peter Godsk , Jensen Gorm Boje , Schnohr Peter , Prescott Eva , Søgaard Peter , Møgelvang Rasmus , Biering‐Sørensen Tor 
Published: May 2021

AbstractBackgroundThe ratio of transmitral early filling velocity to early diastolic strain rate (E/e'sr) may be a more accurate measure of LV filling pressure then ratio of early filling pressure to early tissue velocity. The aim of the study was to investigate the impact of age, sex, obesity, smoking, hypertension, hypercholesterolemia, diabetes, physical activity level, socioeconomic, and psychosocial status on E/e'sr over a decade. Additionally, the predictive value of ΔE/e'sr on future major adverse cardiovascular events (MACE) has never been explored.MethodThe study included 623 participants from the general population, who participated in the 4th and 5th Copenhagen City Heart Study (CCHS4 and CCHS5). Examinations were median 10 years apart. MACE was the composite endpoint of heart failure, myocardial infarction, and all‐cause death.ResultsFollow‐up time was median 5.7 years, and 43 (7%) experienced MACE. Mean age was 51 ± 14 years, and 43% were male. Mean ΔE/e'sr was 2.1 ± 23.0 cm. After multivariable adjustment for demographic, clinical, and biochemistry variables, high age (stand. β‐coef. = .24, P < .001) and mean arterial blood pressure (MAP) (stand. β‐coef. = .17, P < .001) were significantly associated with an accelerated increase in E/e'sr In multivariable Cox regression, E/e'sr at CCHS5 and ΔE/e'sr were independent predictors of MACE (HR = 1.20, 95% CI [1.01; 1.42] per 10 cm increase for both). ΔE/e'sr did only provide incremental prognostic value to change in left atrial volume index of the conventional diastolic measurements.ConclusionIn the general population, age and MAP were predictors of an accelerated increase in E/e'sr over a decade. E/e'sr at CCHS5 and ΔE/e'sr were independent predictors of future MACE.
State anxiety modulates the effect of emotion cues on visual temporal sensitivity in autism spectrum disorder
Authors: Chakrabarty Mrinmoy , Atsumi Takeshi , Kaneko Ayako , Fukatsu Reiko , Ide Masakazu 
Published: May 2021

AbstractAtypical processing of stimulus inputs across a range of sensory modalities in autism spectrum disorder (ASD) is widely reported. Sensory processing is known to be influenced by bodily internal states such as physiological arousal and anxiety. As a sizeable proportion of ASD reportedly have co‐morbid anxiety disorders that are linked with dysregulated arousal, we investigated if face emotion arousal cues influenced visual sensory sensitivity (indexed by temporal resolution) in ASD (n = 20) compared to a matched group of typically developed individuals (TD, n = 21). We asked further if emotion‐cued changes in visual sensitivity were associated with individual differences in state and trait anxiety. Participants reported the laterality of the second of two consecutive Gaussian‐blob flashes in a visual temporal order judgment task (v‐TOJ), demanding higher‐level visual processing. The key manipulation was presenting a task‐irrelevant face emotion cue briefly at unexpected time points preceding the task‐relevant flashes. Disgust vs. Neutral emotion signals significantly enhanced the visual temporal resolution in ASD. Individual state‐anxiety scores showed a fair correlative trend with the emotion‐cued changes in temporal resolution (Disgust versus Neutral) in ASD but missed statistical significance. Both these effects were absent in TD. The results show that individual state‐anxiety levels likely modulate the effect of emotions on visual temporal sensitivity in ASD. The findings support a nuanced approach to understand the disparate sensory features in ASD, by factoring in the interplay of the individual reactivity to environmental affective information and the severity of anxiety.
Light stimulation during postnatal development is not determinant for glutamatergic neurotransmission from the retinohypothalamic tract to the suprachiasmatic nucleus in rats
Authors: Reyes‐Mendez Miriam E. , Herrera‐Zamora J. Manuel , Osuna‐López Fernando , Navarro‐Polanco Ricardo A. , Mendoza‐Muñoz Néstor , Góngora‐Alfaro José L. , Moreno‐Galindo Eloy G. , Alamilla Javier 
Published: May 2021

AbstractThe hypothalamic suprachiasmatic nucleus (SCN) is the leading circadian pacemaker in mammals, which synchronizes with environmental light through the retinohypothalamic tract (RHT). Although the SCN regulates circadian rhythms before birth, postnatal synaptic changes are needed for the RHT‐SCN pathway to achieve total functional development. However, it is unknown whether visual experience affects developmental maturation. Here, we studied the effects of constant darkness (DD) rearing on the physiology (at pre‐ and postsynaptic levels) of glutamatergic neurotransmission between RHT and SCN during postnatal development in rats. Upon recording spontaneous and evoked excitatory postsynaptic currents (EPSCs) by electrical stimulation of RHT fibers, we found that DD animals at early postnatal ages (P3–19) exhibited different frequencies of spontaneous EPSCs and lower synaptic performance (short‐term depression, release sites, and recruitment of RHT fibers) when compared with their normal light/dark (LD) counterparts. At the oldest age evaluated (P30–35), there was a synaptic response strengthening (probability of release, vesicular re‐filling rate, and reduced synaptic depression) in DD rats, which functionally equaled (or surmounted) that of LD animals. Control experiments evaluating EPSCs in ventral SCN neurons of LD rats during day and night revealed no significant differences in spontaneous or evoked EPSCs by high‐frequency trains in the RHT at any postnatal age. Our results suggest that DD conditions induce a compensatory mechanism in the glutamatergic signaling of the circadian system to increase the chances of synchronization to light at adult ages, and that the synaptic properties of RHT terminals during postnatal development are not critically influenced by environmental light.
Habitat determines the relationships among bacteria, resistance genes and mobile genetic elements in the soil–plant system
Authors: Huang Ruilin , Ding Jixian , Guo Yuwei , Sun Bo , Liang Yuting 
Published: May 2021

AbstractThe soil antibiotic resistome is considered to be primarily determined by bacterial community composition. However, the antibiotic resistance of plant microbiota and its association with the soil microbiome in soil–plant systems remain largely unknown. Here, we studied the connections between bacteria and resistance genes (RGs) (mainly antibiotic resistance genes, ARGs) and mobile genetic elements (MGEs) in different cropping systems (rice monoculture, and ryegrass–rice and vetch–rice rotation), growth periods (early, tillering and harvesting stages) and habitats (the soil, rhizoplane and phyllosphere) through high‐throughput qPCR and 16S rRNA sequencing. The results showed that habitat was the major factor affecting the distribution of bacteria, RGs and MGEs, whereas the cropping system had less of an effect. The relative abundances of ARGs, multidrug resistance genes, metal resistance genes and integrons were highest in the soil and lowest in the phyllosphere, as was the α‐diversity of the soil and plant microbiota. Most importantly, we found that bacteria had the strongest associations with RGs and MGEs in the rhizoplane rather than in the soil and phyllosphere, which might be due to the high network interactions among rhizoplane bacteria. These results suggest that the rhizoplane could be a hotspot for exchange of ARGs in the soil–plant system.Highlights
The distributions of bacteria, RGs and MGEs were primarily controlled by habitat.
The strongest associations were found between rhizoplane bacteria and RGs and MGEs.
Rhizoplane bacteria had the strongest network associations.