bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 variants resist antibody neutralization and broaden host ACE2 usage
Authors: Wang Ruoke , Zhang Qi , Ge Jiwan , Ren Wenlin , Zhang Rui , Lan Jun , Ju Bin , Su Bin , Yu Fengting , Chen Peng , Liao Huiyu , Feng Yingmei , Li Xuemei , Shi Xuanling , Zhang Zheng , Zhang Fujie , Ding Qiang , Zhang Tong , Wang Xinquan , Zhang Linqi 
Published: March 2021

AbstractNew SARS-CoV-2 variants continue to emerge from the current global pandemic, some of which can replicate faster and with greater transmissibility and pathogenicity. In particular, UK501Y.V1 identified in UK, SA501Y.V2 in South Africa, and BR501Y.V3 in Brazil are raising serious concerns as they spread quickly and contain spike protein mutations that may facilitate escape from current antibody therapies and vaccine protection. Here, we constructed a panel of 28 SARS-CoV-2 pseudoviruses bearing single or combined mutations found in the spike protein of these three variants, as well as additional nine mutations that within or close by the major antigenic sites in the spike protein identified in the GISAID database. These pseudoviruses were tested against a panel of monoclonal antibodies (mAbs), including some approved for emergency use to treat SARS-CoV-2 infection, and convalescent patient plasma collected early in the pandemic. SA501Y.V2 pseudovirus was the most resistant, in magnitude and breadth, against mAbs and convalescent plasma, followed by BR501Y.V3, and then UK501Y.V1. This resistance hierarchy corresponds with Y144del and 242-244del mutations in the N-terminal domain as well as K417N/T, E484K and N501Y mutations in the receptor binding domain (RBD). Crystal structural analysis of RBD carrying triple K417N-E484K-N501Y mutations found in SA501Y.V2 bound with mAb P2C-1F11 revealed a molecular basis for antibody neutralization and escape. SA501Y.V2 and BR501Y.V3 also acquired substantial ability to use mouse and mink ACE2 for entry. Taken together, our results clearly demonstrate major antigenic shifts and potentially broadening the host range of SA501Y.V2 and BR501Y.V3, which pose serious challenges to our current antibody therapies and vaccine protection.
A comprehensive computational investigation into the conserved virulent proteins ofShigellasp unveils potential siRNA candidates as a new therapeutic strategy against shigellosis
Authors: Palit Parag , Chowdhury Farhana Tasnim , Baruah Namrata , Sarkar Bonoshree , Mou Sadia Noor , Kamal Mehnaz , Siddiqua Towfida Jahan , Noor Zannatun , Ahmed Tahmeed 
Published: March 2021

AbstractShigellasp account for the second-leading cause of deaths due to diarrheal diseases among children of less than 5 years of age. Emergence of multi-drug resistantShigellaisolates and the lack of availability ofShigellavaccines have made the efforts in the development of new therapeutic strategies against shigellosis very pertinent. In our study we have analyzed a total of 241 conserved sequences from a 15 different conserved virulence genes ofShigellasp and through extensive rational validation using a plethora of computational algorithms; we primarily obtained fifty eight small-interfering RNA (siRNA) candidates. Further extensive computational validation showed only three siRNA candidates that were found to exhibit substantial functional efficacy, be non-immunogenic and have a thermodynamically stable and sterically feasible and thereby acceptable tertiary structure. These siRNA candidates are intended to suppress the expression of the virulence genes, namely: IpgD (siRNA 9) and OspB (siRNA 15 and siRNA 17) and thus act as a prospective tool in the RNA interference (RNAi) pathway. However, the findings of our study require further wet lab validation and optimization for regular therapeutic use in the treatment of shigellosis.
Electrophysiological signatures of hierarchical learning
Authors: Liu Meng , Dong Wenshan , Qin Shaozheng , Verguts Tom , Chen Qi 
Published: March 2021

AbstractHuman perception and learning is thought to rely on a hierarchical generative model that is continuously updated via precision-weighted prediction errors (pwPEs). However, the neural basis of such cognitive process and how it unfolds during decision making, remain poorly understood. To investigate this question, we combined a hierarchical Bayesian model (i.e., Hierarchical Gaussian Filter, HGF) with electrophysiological (EEG) recording, while participants performed a probabilistic reversal learning task in alternatingly stable and volatile environments. Behaviorally, the HGF fitted significantly better than two control, non-hierarchical, models. Neurally, low-level and high-level pwPEs were independently encoded by the P300 component. Low-level pwPEs were reflected in the theta (4-8 Hz) frequency band, but high-level pwPEs were not. Furthermore, the expressions of high-level pwPEs were stronger for participants with better HGF fit. These results indicate that the brain employs hierarchical learning, and encodes both low- and high-level learning signals separately and adaptively.
Genome features of common vetch (Vicia sativa) in natural habitats
Authors: Shirasawa Kenta , Kosugi Shunichi , Sasaki Kazuhiro , Ghelfi Andrea , Okazaki Koei , Toyoda Atsushi , Hirakawa Hideki , Isobe Sachiko 
Published: March 2021

AbstractWild plants are often tolerant to biotic and abiotic stresses in their natural environments, whereas domesticated plants such as crops frequently lack such resilience. This difference is thought to be due to the high levels of genome heterozygosity in wild plant populations and the low levels of heterozygosity in domesticated crop species. In this study, common vetch (Vicia sativa) was used as a model to examine this hypothesis. The common vetch genome (2n = 14) was estimated as 1.8 Gb in size. Genome sequencing produced a reference assembly that spanned 1.5 Gb, from which 31,146 genes were predicted. Using this sequence as a reference, 24,118 single nucleotide polymorphisms were discovered in 1,243 plants from 12 natural common vetch populations in Japan. Common vetch genomes exhibited high heterozygosity at the population level, with lower levels of heterozygosity observed at specific genome regions. Such patterns of heterozygosity are thought to be essential for adaptation to different environments. These findings suggest that high heterozygosity at the population level would be required for wild plants to survive under natural conditions while allowing important gene loci to be fixed to adapt the conditions. The resources generated in this study will provide insights intode novodomestication of wild plants and agricultural enhancement.HighlightSequence analysis of the common vetch(Vicia sativa)genome and SNP genotyping across natural populations revealed nucleotide diversity levels associated with native population environments.
A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology
Authors: Lacoste Jérôme , Soula Hédi , Burg Angélique , Audibert Agnès , Darnat Pénélope , Gho Michel , Louvet-Vallée Sophie 
Published: March 2021

SUMMARYSpatiotemporal mechanisms generating neural diversity are fundamental for understanding neural processes. Here, we investigated how neural diversity arises from neurons coming from identical progenitors. In the dorsal thorax ofDrosophila, rows of mechanosensory organs originate from the division of sensory organ progenitor (SOPs). We show that in each row of the notum, a central SOP divides first, then neighboring SOPs divide, and so on. This centrifugal wave of mitoses depends on cell-cell inhibitory interactions mediated by SOP cytoplasmic protrusions and Scabrous, a secreted protein interacting with the Delta/Notch complex. Furthermore, when the mitotic wave was abolished, axonal growth was more synchronous, axonal terminals had a complex branching pattern and fly behavior was impaired. We show that the temporal order of progenitor divisions influences the birth order of sensory neurons, axon branching and impact on grooming behavior. These data support the idea that developmental timing controls axon wiring neural diversity.
Self-efficacy and continuance intention of Web 2.0 platforms: a meta-analysis
Authors: Bao Zheshi , Shang Bo 
Published: March 2021

PurposeAlthough many studies show that self-efficacy and continuance intention of Web 2.0 platforms are positively and significant correlated, others reveal some different findings. To clarify this line of research, this study further investigates the effect of self-efficacy on continuance intention and meanwhile examines some moderating variables in this process.Design/methodology/approachA meta-analysis method was employed to examine the literature containing quantitative measurements of both self-efficacy and continuance intention of Web 2.0 platforms. A total of 31 effects sizes (N = 9,084) were reviewed.FindingsThe results indicate medium-sized positive correlation between self-efficacy and continuance intention of Web 2.0 platforms. Further moderation analysis shows that such medium-sized link differed across measures of Web 2.0 platform types, target respondent differences and gender of participants. Specifically, this correlation is largest for transaction-socialization platforms and smallest for experience-socialization platforms. For university-student respondents, the role of self-efficacy in affecting continuance intention is less important than general members of Web 2.0 platforms. Finally, as the percentage of female participants increases, a weaker effect size will be observed.Originality/valueThis study clarifies empirical research regarding users' self-efficacy and their continuance intention. Meanwhile, sources of inter-study variability have been identified by addressing moderator variables in the relationship between self-efficacy and continuance intention of Web 2.0 platforms, which provides directions for future explorations in this area.
Gender equality and the business case in horse racing
Authors: Manfredi Simonetta , Clayton-Hathway Kate 
Published: March 2021

PurposeThe purpose of this paper is to discuss the findings and outcomes from research undertaken in 2016 on diversity in British horse racing. The last decade has seen increasing focus on improving gender balance in senior roles in most sectors. Motivation for change within horse racing came from women at a senior level, who identified that the industry was behind in this respect. This work offers a case study to consider, with a business case context, whether an initiative, driven from the top, can open up a conversation about inequality and precipitate change that benefits women across a whole sector.Design/methodology/approachThis research took an action research approach using a survey alongside key stakeholder interviews.FindingsThe findings showed a diverse industry with complex career paths. Growing numbers of women have entered the sector, though this was often not reflected in women's seniority or in perceptions about their capabilities. Issues identified included the importance of mentoring, networking and career advice for women's progression, which are needed to navigate myriad career paths and male-dominated structures. The paper argues that investigating equality issues from a perspective of those in leadership roles can lead to pragmatic initiatives supporting women at all levels.Originality/valueThe originality of this paper is that it focuses on work which, for the first time, explored women's career participation in the horse racing industry. It challenges existing critiques of using a business case to promote gender equality.
Systematic literature review of food waste in educational institutions: setting the research agenda
Authors: Kaur Puneet , Dhir Amandeep , Talwar Shalini , Alrasheedy Melfi 
Published: March 2021

PurposeIn the recent past, academic researchers have noted the quantity of food wasted in food service establishments in educational institutions. However, more granular inputs are required to counter the challenge posed. The purpose of this study is to undertake a review of the prior literature in the area to provide a platform for future research.Design/methodology/approachTowards this end, the authors used a robust search protocol to identify 88 congruent studies to review and critically synthesize. The research profiling of the selected studies revealed limited studies conducted on food service establishments in universities. The research is also less dispersed geographically, remaining largely focused on the USA. Thereafter, the authors performed content analysis to identify seven themes around which the findings of prior studies were organized.FindingsThe key themes of the reviewed studies are the drivers of food waste, quantitative assessment of food waste, assessment of the behavioural aspects of food waste, operational strategies for reducing food waste, interventions for inducing behavioural changes to mitigate food waste, food diversion and food waste disposal processes and barriers to the implementation of food waste reduction strategies.Research limitations/implicationsThis study has key theoretical and practical implications. From the perspective of research, the study revealed various gaps in the extant findings and suggested potential areas that can be examined by academic researchers from the perspective of the hospitality sector. From the perspective of practice, the study recommended actionable strategies to help managers mitigate food waste.Originality/valueThe authors have made a novel contribution to the research on food waste reduction by identifying theme-based research gaps, suggesting potential research questions and proposing a framework based on the open-systems approach to set the future research agenda.
Performance measurement in smart city governance: a case study of an Egyptian city council
Authors: Alsaid Loai Ali Zeenalabden Ali 
Published: March 2021

PurposeThis study seeks to explore the powerful role(s) of institutionalised performance measurement systems or metrics in smart city governance in a politically and militarily sensitive developing country.Design/methodology/approachThis study extends the application and contribution of a multi-level institutional framework to previous management accounting literature on the potential relationship between performance measurement and smart city governance. The value of utilising a multi-level framework is to broaden and deepen theoretical analyses about this relationship to include the effect of political pressure from the military regime at the macro level on the institutionalisation of a performance measurement system at the micro-organisational level. Taking the New Cairo city council smart electricity networks project (Egypt) as an interpretive qualitative single-case study, data collection methods included semi-structured interviews, direct observations and documentary readings.FindingsPerformance measurement systems or metrics, especially in politically and militarily sensitive smart cities, constitutes a process of cascading (macro-micro) institutionalisation that is closely linked to sustainable developments taking place in the wider arena of urban policies. Going a step further, accounting-based performance metrics, arising from political and military pressures towards public-private collaborations, contribute to smart city management and accountability (governance). Institutionalised measurement systems or performance metrics play a powerful accounting role(s) in shaping and reshaping political decisions and military actions in the city council.Originality/valueTheoretically, this study goes beyond the cascading institutionalisation process by arguing for the powerful role(s) of institutionalised accounting and performance measurement systems in smart city decision-making and governance. Empirically, it enriches previous literature with a case study of a developing Arab Spring country, characterised by an emerging economy, political sensitivity and military engagement, rather than developed and more stable countries that have been thoroughly investigated. It is also among the first politically engaged accounting case studies to highlight public-private collaborations as a recent reform in public sector governance and accountability.
ViewpointRuminations on peer review in the time of social change
Authors: Dali Keren 
Published: March 2021

PurposeThis viewpoint article looks at several approaches to peer review that become detrimental to the scholarly process and disadvantage diverse voices in the scholarly conversation.Design/methodology/approachAs a viewpoint article, the piece relies on published research and the author's personal experience as an author and a journal editor.FindingsThe article focuses on the manuscript structure; manuscript length expectations; and several immediately obvious effects of the COVID-19 pandemic on the scholarly communication process.Originality/valueThe article addresses the aforementioned aspects of peer review with a goal of contemplating their cumulative impact on the state of diversity in scholarly communication and suggests possible ways of rethinking the situation.
Institutional reforms, control of corruption, and diaspora entrepreneurship: insights and perspectives on America's poorest economy
Authors: Mombeuil Claudel , Fotiadis Anestis K. , Aimable Withz 
Published: March 2021

PurposeWhile diaspora entrepreneurs remain important sources of capital and innovation, many developing countries are facing serious challenges to tap into these sources because of their weak institutional settings and the endemic and systemic corruption. To this end, this study explores how institutional reforms and control of corruption can influence diaspora entrepreneurship. This study also seeks to provide perspectives on how diaspora entrepreneurs can influence institutional reforms and market policies.Design/methodology/approachTo meet these objectives, qualitative and interpretive research approaches were employed.FindingsUsing responses collected from Haitian diaspora entrepreneurs living in the USA, this paper highlights different attributes of institutional reforms and control of corruption that can influence diaspora entrepreneurship.Practical implicationsBased on these insights, this paper argues that Haitian diaspora entrepreneurs need to play a proactive role as policy entrepreneurs by supporting competent and well-intention political leaders to gain office and by joining forces with local actors to advocate for institutional reforms, market reforms and control of corruption in order to be able to exploit market opportunities. In this respect, further perspectives for diaspora entrepreneurship, limitations and consideration for future research are highlighted.Originality/valueBy collecting insights on institutional reform and diaspora entrepreneurship from diaspora entrepreneurs, this paper makes important contribution to the entrepreneurship literature.
Antecedents of online word-of-mouth reviews on hotels
Authors: Moliner-Velázquez Beatriz , Fuentes-Blasco Maria , Gil-Saura Irene 
Published: March 2021

PurposeThe word-of-mouth comments considered as the evaluation of a purchase experience have been widely discussed in the literature. Nevertheless, the study of online reviews pre-purchase stage remains limited. The purpose of this study is to analyze the variables that support word-of-mouth adoption in the choice of the hotel, from the receiver perspective.Design/methodology/approachThe information was collected by face-to-face survey to 393 guests from 32 hotels in two Spanish cities. Structural equation modeling was applied to test the hypotheses.FindingsThe results confirm the significant and indirect effects of the motivations for conducting reviews on online word-of-mouth adoption. Specifically, the significant relationship chain of convenience and risk reduction motivations, intention to consult online comments, volume of comments exert a significant influence on acceptance the suggestions in online reviews and recommendations about the hotels.Research limitations/implicationsThe study of these variables advances the literature on online word-of-mouth by analyzing in-depth the antecedents of the purchase decision using technologies. From the practical point of view, the results help hotels managers to improve the way to share information by facilitating access to the accommodation experiences of other consumers.Originality/valueThe novelty of this research is mainly found in the study of how consumers modify their behavior using online word-of-mouth reviews. From the receiver perspective, consumer motivations, word-of-mouth volume and intention to consult serve as antecedents of purchase decision.
Ecosystems in support of social entrepreneurs: a literature review
Authors: Diaz Gonzalez Abel , Dentchev Nikolay A. 
Published: March 2021

Purpose
Social entrepreneurs (SEs) often face various challenges whereby they rely on the support of others to realize their objectives. In this context, ecosystem thinking is very helpful to understand how various stakeholders can assist SEs. The purpose of this paper is to develop a classification of the different types of support that third parties can provide to SEs.

Design/methodology/approach
The authors have developed the arguments in this paper based on a literature review of 258 articles on ecosystem thinking and social entrepreneurship. Articles have been retrieved from the Web of Science database, using as search parameters on the one hand publications in top journals, and on the other articles with more than 60 citations. In addition, the authors have received recommendations for relevant good-quality articles following a snowball procedure.

Findings
This paper contributes by distinguishing three support categories for SEs – fuel, hardware and DNA – based on what we know from ecosystem thinking. This paper elaborates on the building blocks of each support category, points at the relevant actors and discusses the interrelatedness across support categories.

Research limitations/implications
The three support categories are developed by building on predominantly ecosystem literature. This study implies that the scalability of SEs’ social impact does not only depend on their strengths but also on how well they are supported.

Practical implications
The three support categories are complementary to the strengths of individual SEs. SEs can therefore start with what they have, and then gradually expand their support structure by surrounding themselves with stakeholders that can assist them with fuel, infrastructure and DNA.

Originality/value
Social enterprise theories have elaborated on the various challenges that SEs face. Lack of resources, lack of staff, lack of professional management, underdeveloped networks and mission drift are seen as the most pressing. Although the relevant literature does rightly point out the indispensable support of others, it does so without differentiating between the kinds of support that can help SEs increase their social impact. This paper offers to remedy this by creating three separate support categories: fuel, hardware and DNA.