bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symposium on Barry Eidlin’s Labor and the Class Idea in the United States and Canada
Authors: Lichtenstein Nelson , de Leon Cedric , Stepan-Norris Judith , Eidlin Barry 
Published: August 2021

AbstractBarry Eidlin’s book, Labor and the Class Idea in the United States and Canada (Cambridge University Press, 2018) explains why unions are weaker in the United States than they are in Canada, but have not always been that way. Indeed, unionization rates were virtually identical for much of the twentieth century, then diverged in the 1960s. Against dominant accounts focused on long-standing differences in political cultures and institutions, Eidlin argues that the divergence resulted from different ruling party responses to working class upsurge in both countries during the Great Depression and World War II. In Canada, an initially more hostile state response ended up embedding “the class idea”—the idea of class as a salient, legitimate political category—more deeply in policies, policies, and practices than in the United States, where class interests were reduced to “special interests.” In this symposium, three noted labor scholars engage critically with the book. Cedric de Leon interrogates Eidlin’s account of the role of racial divisions in explaining divergence, noting “more persistence and convergence than there is rupture and divergence” between these two countries on this issue. Nelson Lichtenstein’s critique focuses on the exceptionally vociferous character of US employer hostility, which he argues that Eidlin downplays. And Judith Stepan-Norris notes the surprising lack of actual class actors in a book about class organization, while raising interpretive questions about the relation between labor and the Communist Party in both countries. Eidlin concludes the symposium with a response to the critics.
Where Does Moisture Come From Over the Congo Basin?
Authors: Worden Sarah , Fu Rong , Chakraborty Sudip , Liu Junjie , Worden John 
Published: August 2021

AbstractThe Congo Basin hosts the world's second largest rainforest and is a major rainfall center. However, the primary sources of moisture needed to maintain this forest, either from evapotranspiration (ET) or advection from the ocean, remain unclear. We use satellite observations of the deuterium content of water vapor (), solar induced fluorescence (SIF), precipitation, and atmospheric reanalysis to examine the relative contribution of ET to moisture in the free troposphere. We find that SIF, an indicator of photosynthesis, covaries with in early rainy seasons, suggesting that ET is an important contributor to atmospheric moisture in both the spring and fall rainy seasons. However, the relative contribution of ET to the free tropospheric moisture varies between the two rainy seasons. Observed relative to a range of observationally constrained, isotopic mixing models representative of water vapor coming from land suggests that of the free tropospheric moisture come from ET in February, and in April, versus in August and in October. Reanalysis indicate that this difference between seasons is due to increased advection of ocean air during the fall season, thus reducing the relative contribution of ET to the Congo Basin in the fall. In addition, ET is the primary atmospheric moisture source in the winter and summer dry seasons, consistent with estimates reported in literature. Our results highlight the importance of ET from the Congo rainforest as an important source of moisture for initiating the rainy seasons.
The Abuse of Popular Performance Metrics in Hydrologic Modeling
Authors: Clark Martyn P. , Vogel Richard M. , Lamontagne Jonathan R. , Mizukami Naoki , Knoben Wouter J. M. , Tang Guoqiang , Gharari Shervan , Freer Jim E. , Whitfield Paul H. , Shook Kevin R. , Papalexiou Simon Michael 
Published: August 2021

AbstractThe goal of this commentary is to critically evaluate the use of popular performance metrics in hydrologic modeling. We focus on the Nash‐Sutcliffe Efficiency (NSE) and the Kling‐Gupta Efficiency (KGE) metrics, which are both widely used in hydrologic research and practice around the world. Our specific objectives are: (a) to provide tools that quantify the sampling uncertainty in popular performance metrics; (b) to quantify sampling uncertainty in popular performance metrics across a large sample of catchments; and (c) to prescribe the further research that is, needed to improve the estimation, interpretation, and use of popular performance metrics in hydrologic modeling. Our large‐sample analysis demonstrates that there is substantial sampling uncertainty in the NSE and KGE estimators. This occurs because the probability distribution of squared errors between model simulations and observations has heavy tails, meaning that performance metrics can be heavily influenced by just a few data points. Our results highlight obvious (yet ignored) abuses of performance metrics that contaminate the conclusions of many hydrologic modeling studies: It is essential to quantify the sampling uncertainty in performance metrics when justifying the use of a model for a specific purpose and when comparing the performance of competing models.
Agricultural Drought Prediction Based on Conditional Distributions of Vine Copulas
Authors: Wu Haijiang , Su Xiaoling , Singh Vijay P. , Feng Kai , Niu Jiping 
Published: August 2021

AbstractMonitoring and prediction of agricultural drought are paramount to food security at the global and regional scales, particularly under the influence of climate change and anthropogenic activities. Soil moisture is an effective indicator for monitoring and characterizing agricultural drought. Soil moisture (agricultural drought) is mainly affected by precipitation (meteorological drought) and temperature (hot conditions). Owing to the flexibility of vine copulas in handling multidimensional variables by decomposing them into pair copula constructions (PCCs), we propose a novel drought prediction method using three predictors, namely antecedent meteorological drought, previous hot conditions, and persistent agricultural drought, based on the conditional distributions of C‐vine copulas in a four‐dimensional scenario. The proposed model was applied to agricultural drought (characterized by the standardized soil moisture index (SSI)) prediction with 1–2‐months lead time for the summer season (i.e., August at a 6‐months timescale) in China. Taking two severe agricultural drought events that occurred in many regions across China in August of 2006 and 2014 as validation cases, the SSI predictions with 1–2‐months lead time using the conditional C‐vine copulas model were found to be generally consistent with the corresponding historical SSI observations in most parts of China. Performance evaluation using the Nash‐Sutcliffe efficiency (NSE), coefficient of determination (R2), and F1 score (F1S) for different climate regions also indicated that this model provided a reliable prediction of agricultural drought for most areas of China. The outcome of this study can serve as a guidance for drought prediction, early warning, and drought mitigation.
Calibration‐Free Complementary Relationship Estimates Terrestrial Evapotranspiration Globally
Authors: Ma Ning , Szilagyi Jozsef , Zhang Yongqiang 
Published: August 2021

AbstractWhile large‐scale terrestrial evapotranspiration (ET) information is essential for our understanding of the Earth's water and energy cycles, substantial differences exist in current global ET products due partly to uncertainties in soil‐ and vegetation‐related parameters and/or precipitation forcing. Here a calibration‐free complementary relationship (CR) model, driven purely by routine meteorological forcing (air and dew‐point temperature, wind speed, and net radiation), mainly from ERA5, was employed to estimate global ET rates during 1982–2016. Modeled ET agrees favorably with (a) monthly eddy‐covariance measurements of 129 global FLUXNET sites, and; (b) water‐balance‐derived ET of 52 basins at the multiyear mean and annual scales. Additional evaluations demonstrate that the CR is very competitive, in comparison with other 12 widely used global ET products. The 35‐years mean global land ET rate from the CR is 500 ± 6 mm yr−1 (72.3 ± 0.9 × 103 km3 yr−1) with more than 70% of the land area exhibiting increasing annual ET rates over the study period. Globally, CR ET significantly increased at a rate of 0.31 mm yr−1 during 1982–2016, suggesting a 2.2% increase in global land ET over last 35 years. Model inter‐comparisons indicate that global annual CR ET values and their trend are close to the median of not only the 12 ET products chosen but also that of 20 CMIP6 models. Since this calibration‐free CR model requires no precipitation (except in sea‐shore deserts for a subsequent ET correction), vegetation or soil data, it could be incorporated into complex hydrological and/or climate models, thereby facilitating large‐scale hydrological and climate simulations.
Neural network modelling reveals changes in directional connectivity between cortical and hypothalamic regions with increased BMI
Authors: Voigt Katharina , Razi Adeel , Harding Ian H. , Andrews Zane B. , Verdejo-Garcia Antonio 
Published: August 2021

AbstractBackground/ObjectivesObesity has been ascribed to corticostriatal regions taking control over homeostatic areas. To test this assumption, we applied an effective connectivity approach to reveal the direction of information flow between brain regions and the valence of connections (excitatory versus inhibitory) as a function of increased BMI and homeostatic state.Subjects/MethodsForty-one participants (21 overweight/obese) underwent two resting-state fMRI scans: after overnight fasting (hunger) and following a standardised meal (satiety). We used spectral dynamic causal modelling to unravel hunger and increased BMI-related changes in directed connectivity between cortical, insular, striatal and hypothalamic regions.ResultsDuring hunger, as compared to satiety, we found increased excitation of the ventromedial prefrontal cortex over the ventral striatum and hypothalamus, suggesting enhanced top-down modulation compensating energy depletion. Increased BMI was associated with increased excitation of the anterior insula over the hypothalamus across the hunger and satiety conditions. The interaction of hunger and increased BMI yielded decreased intra-cortical excitation from the dorso-lateral to the ventromedial prefrontal cortex.ConclusionsOur findings suggest that excess weight and obesity is associated with persistent top-down excitation of the hypothalamus, regardless of homeostatic state, and hunger-related reductions of dorso-lateral to ventromedial prefrontal inputs. These findings are compatible with eating without hunger and reduced self-regulation views of obesity.
Diurnal variations of brown fat thermogenesis and fat oxidation in humans
Authors: Matsushita Mami , Nirengi Shinsuke , Hibi Masanobu , Wakabayashi Hitoshi , Lee Sang-il , Domichi Masayuki , Sakane Naoki , Saito Masayuki 
Published: August 2021

Abstract
Background/objectives
Disturbed circadian rhythm is associated with an increased risk of obesity and metabolic disorders. Brown adipose tissue (BAT) is a site of nonshivering thermogenesis (NST) and plays a role in regulating whole-body energy expenditure (EE), substrate metabolism, and body fatness. In this study, we examined diurnal variations of NST in healthy humans by focusing on their relation to BAT activity.

Methods
Forty-four healthy men underwent 18F-fluoro-2-deoxy-D-glucose positron emission tomography and were divided into Low-BAT and High-BAT groups. In STUDY 1, EE, diet-induced thermogenesis (DIT), and fat oxidation (FO) were measured using a whole-room indirect calorimeter at 27 °C. In STUDY 2, EE, FO, and skin temperature in the region close to BAT depots (Tscv) and in the control region (Tc) were measured at 27 °C and after 90 min cold exposure at 19 °C in the morning and in the evening.

Results
In STUDY 1, DIT and FO after breakfast was higher in the High-BAT group than in the Low-BAT group (P < 0.05), whereas those after dinner were comparable in the two groups. FO in the High-BAT group was higher after breakfast than after dinner (P < 0.01). In STUDY 2, cold-induced increases in EE (CIT), FO, and Tscv relative to Tc in the morning were higher in the High-BAT group than in the Low-BAT group (P < 0.05), whereas those after dinner were comparable in the two groups. CIT in the High-BAT group tended to be higher in the morning than in the evening (P = 0.056).

Conclusion
BAT-associated NST and FO were evident in the morning, but not in the evening, suggesting that the activity of human BAT is higher in the morning than in the evening, and thus may be involved in the association of an eating habit of breakfast skipping with obesity and related metabolic disorders.
Optimization of the fused deposition modeling-based fabrication process for polylactic acid microneedles
Authors: Wu Libo , Park Jongho , Kamaki Yuto , Kim Beomjoon 
Published: August 2021

AbstractA microneedle (MN) array is a novel biomedical device adopted in medical applications to pierce through the stratum corneum while targeting the viable epidermis and dermis layers of the skin. Owing to their micron-scale dimensions, MNs can minimize stimulations of the sensory nerve fibers in the dermis layer. For medical applications, such as wound healing, biosensing, and drug delivery, the structure of MNs significantly influences their mechanical properties. Among the various microfabrication methods for MNs, fused deposition modeling (FDM), a commercial 3D printing method, shows potential in terms of the biocompatibility of the printed material (polylactic acid (PLA)) and preprogrammable arbitrary shapes. Owing to the current limitations of FDM printer resolution, conventional micron-scale MN structures cannot be fabricated without a post-fabrication process. Hydrolysis in an alkaline solution is a feasible approach for reducing the size of PLA needles printed via FDM. Moreover, weak bonding between PLA layers during additive manufacturing triggers the detachment of PLA needles before etching to the expected sizes. Furthermore, various parameters for the fabrication of PLA MNs with FDM have yet to be sufficiently optimized. In this study, the thermal parameters of the FDM printing process, including the nozzle and printing stage temperatures, were investigated to bolster the interfacial bonding between PLA layers. Reinforced bonding was demonstrated to address the detachment challenges faced by PLA MNs during the chemical etching process. Furthermore, chemical etching parameters, including the etchant concentration, environmental temperature, and stirring speed of the etchant, were studied to determine the optimal etching ratio. To develop a universal methodology for the batch fabrication of biodegradable MNs, this study is expected to optimize the conditions of the FDM-based fabrication process. Additive manufacturing was employed to produce MNs with preprogrammed structures. Inclined MNs were successfully fabricated by FDM printing with chemical etching. This geometrical structure can be adopted to enhance adhesion to the skin layer. Our study provides a useful method for fabricating MN structures for various biomedical applications.
Petrobactin, a siderophore produced by Alteromonas, mediates community iron acquisition in the global ocean
Authors: Manck Lauren E , Park Jiwoon , Tully Benjamin J , Poire Alfonso M , Bundy Randelle M , Dupont Christopher L , Barbeau Katherine A 
Published: August 2021

Abstract
It is now widely accepted that siderophores play a role in marine iron biogeochemical cycling. However, the mechanisms by which siderophores affect the availability of iron from specific sources and the resulting significance of these processes on iron biogeochemical cycling as a whole have remained largely untested. In this study, we develop a model system for testing the effects of siderophore production on iron bioavailability using the marine copiotroph Alteromonas macleodii ATCC 27126. Through the generation of the knockout cell line ΔasbB::kmr, which lacks siderophore biosynthetic capabilities, we demonstrate that the production of the siderophore petrobactin enables the acquisition of iron from mineral sources and weaker iron-ligand complexes. Notably, the utilization of lithogenic iron, such as that from atmospheric dust, indicates a significant role for siderophores in the incorporation of new iron into marine systems. We have also detected petrobactin, a photoreactive siderophore, directly from seawater in the mid-latitudes of the North Pacific and have identified the biosynthetic pathway for petrobactin in bacterial metagenome-assembled genomes widely distributed across the global ocean. Together, these results improve our mechanistic understanding of the role of siderophore production in iron biogeochemical cycling in the marine environment wherein iron speciation, bioavailability, and residence time can be directly influenced by microbial activities.
Bacterial controlled mitigation of dysbiosis in a seaweed disease
Authors: Li Jiasui , Majzoub Marwan E , Marzinelli Ezequiel M , Dai Zhicong , Thomas Torsten , Egan Suhelen 
Published: August 2021

Abstract
Disease in the marine environment is predicted to increase with anthropogenic stressors and already affects major habitat-formers, such as corals and seaweeds. Solutions to address this issue are urgently needed. The seaweed Delisea pulchra is prone to a bleaching disease, which is caused by opportunistic pathogens and involves bacterial dysbiosis. Bacteria that can inhibit these pathogens and/or counteract dysbiosis are therefore hypothesised to reduce disease. This study aimed to identify such disease-protective bacteria and investigate their protective action. One strain, Phaeobacter sp. BS52, isolated from healthy D. pulchra, was antagonistic towards bleaching pathogens and significantly increased the proportion of healthy individuals when applied before the pathogen challenge (pathogen-only vs. BS52 + pathogen: 41–80%), and to a level similar to the control. However, no significant negative correlations between the relative abundances of pathogens and BS52 on D. pulchra were detected. Instead, inoculation of BS52 mitigated pathogen-induced changes in the epibacterial community. These observations suggest that the protective activity of BS52 was due to its ability to prevent dysbiosis, rather than direct pathogen inhibition. This study demonstrates the feasibility of manipulating bacterial communities in seaweeds to reduce disease and that mitigation of dysbiosis can have positive health outcomes.
A general approach to explore prokaryotic protein glycosylation reveals the unique surface layer modulation of an anammox bacterium
Authors: Pabst Martin , Grouzdev Denis S , Lawson Christopher E , Kleikamp Hugo B C , de Ram Carol , Louwen Rogier , Lin Yue Mei , Lücker Sebastian , van Loosdrecht Mark C M , Laureni Michele 
Published: August 2021

Abstract
The enormous chemical diversity and strain variability of prokaryotic protein glycosylation makes their large-scale exploration exceptionally challenging. Therefore, despite the universal relevance of protein glycosylation across all domains of life, the understanding of their biological significance and the evolutionary forces shaping oligosaccharide structures remains highly limited. Here, we report on a newly established mass binning glycoproteomics approach that establishes the chemical identity of the carbohydrate components and performs untargeted exploration of prokaryotic oligosaccharides from large-scale proteomics data directly. We demonstrate our approach by exploring an enrichment culture of the globally relevant anaerobic ammonium-oxidizing bacterium Ca. Kuenenia stuttgartiensis. By doing so we resolve a remarkable array of oligosaccharides, which are produced by two seemingly unrelated biosynthetic routes, and which modify the same surface-layer protein simultaneously. More intriguingly, the investigated strain also accomplished modulation of highly specialized sugars, supposedly in response to its energy metabolism—the anaerobic oxidation of ammonium—which depends on the acquisition of substrates of opposite charges. Ultimately, we provide a systematic approach for the compositional exploration of prokaryotic protein glycosylation, and reveal a remarkable example for the evolution of complex oligosaccharides in bacteria.
PGE2/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib
Authors: Xue Peng , Wang Shenyu , Lyu Xiao , Wan Mei , Li Xialin , Ma Lei , Ford Neil C. , Li Yukun , Guan Yun , Ding Wenyuan , Cao Xu 
Published: August 2021

AbstractSkeletal interoception regulates bone homeostasis through the prostaglandin E2 (PGE2) concentration in bone. Vertebral endplates undergo ossification and become highly porous during intervertebral disc degeneration and aging. We found that the PGE2 concentration was elevated in porous endplates to generate spinal pain. Importantly, treatment with a high-dose cyclooxygenase 2 inhibitor (celecoxib, 80 mg·kg−1 per day) decreased the prostaglandin E2 concentration and attenuated spinal pain in mice with lumbar spine instability. However, this treatment impaired bone formation in porous endplates, and spinal pain recurred after discontinuing the treatment. Interestingly, low-dose celecoxib (20 mg·kg−1 per day, which is equivalent to one-quarter of the clinical maximum dosage) induced a latent inhibition of spinal pain at 3 weeks post-treatment, which persisted even after discontinuing treatment. Furthermore, when the prostaglandin E2 concentration was maintained at the physiological level with low-dose celecoxib, endplate porosity was reduced significantly, which was associated with decreased sensory nerve innervation and spinal pain. These findings suggest that low-dose celecoxib may help to maintain skeletal interoception and decrease vertebral endplate porosity, thereby reducing sensory innervation and spinal pain in mice.
Central and peripheral arterial stiffness responses to uninterrupted prolonged sitting combined with a high-fat meal: a randomized controlled crossover trial
Authors: Fryer Simon , Stone Keeron , Paterson Craig , Brown Meghan , Faulkner James , Lambrick Danielle , Credeur Daniel , Zieff Gabriel , Martínez Aguirre-Betolaza Aitor , Stoner Lee 
Published: August 2021

AbstractIndependently, prolonged uninterrupted sitting and the consumption of a meal high in saturated fats acutely disrupt normal cardiovascular function. Currently, the acute effects of these behaviors performed in combination on arterial stiffness, a marker of cardiovascular health, are unknown. This study sought to determine the effect of consuming a high-fat meal (Δ = 51 g fat) in conjunction with prolonged uninterrupted sitting (180 min) on measures of central and peripheral arterial stiffness. Using a randomized crossover design, 13 young healthy males consumed a high-fat (61 g) or low-fat (10 g) meal before 180 min of uninterrupted sitting. Carotid-femoral (cf) and femoral-ankle (fa) pulse wave velocity (PWV), aortic-femoral stiffness gradient (af-SG), superficial femoral PWV beta (β), and oscillometric pulse wave analysis outcomes were assessed pre and post sitting. cfPWV increased significantly more following the high-fat (mean difference [MD] = 0.59 m·s−1) meal than following the low-fat (MD = 0.2 m·s−1) meal, with no change in faPWV in either condition. The af-SG significantly decreased (worsened) (ηp2 = 0.569) over time in the high- and low-fat conditions (ratio = 0.1 and 0.1, respectively). Superficial femoral PWVβ significantly increased over time in the high- and low-fat conditions (ηp2 = 0.321; 0.8 and 0.4 m·s−1, respectively). Triglycerides increased over time in the high-fat trial only (ηp2 = 0.761). There were no significant changes in blood pressure. Consuming a high-fat meal prior to 180 min of uninterrupted sitting augments markers of cardiovascular disease risk more than consuming a low-fat meal prior to sitting.