bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Mannitol Addition on Hydration in Acute Kidney Injury Event After High Dose Cisplatin Chemotherapy: An Ambispective Cohort Study
Authors: Rachman Andhika , Wafa Syahidatul , Nugroho Pringgodigdo , Koesnoe Sukamto 
Published: June 2021

Abstract
Background: Saline hydration with addition of mannitol have commonly being strategy to avoid cisplatin induced acute kidney injury. While the initial reports demonstrated that mannitol diuresis decreased cisplatin induced renal injury, others have shown renal injury to be worsened.Objective: To compare the risk of acute kidney injury in cancer patients receiving high dose cisplatin with addition and without addition of mannitol.Method: This was an ambispective cohort study based on consecutive sampling at Cipto Mangunkusumo General Hospital and Mochtar Riady Comprehensive Cancer Centre (MRCCC) Siloam Hospitals. The data was obtained from September 2017 to February 2018. The choice of mannitol administration based on responsible physician clinical judgement. The outcome was any increment more than 0,3 mg/dl or 1,5 times from baseline of serum creatinine. Analysis was done by using SPSS statistic for univariate, bivariate and multivariate logistic regression to obtain crude risk ratio and adjusted risk ratio of cisplatin induced acute kidney injury probability of mannitol addition on hydration.Result: Data from 110 patients (57,3% male) with a median age of 44,5 years (range 19 to 60 years) were collected; 47 received saline alone and 63 received saline with addition of mannitol. Acute kidney injury were higher in mannitol vs non mannitol group. Bivariate analysis showed higher probability of post chemotherapy AKI in mannitol group (RR 2,168; 95% CI 0,839-5,6). On multivariate analysis the adjusted RR was 3,52 (95% CI 1,11-11,162; p value = 0,033) by controlling age.Conclusion: The addition of mannitol on hydration had higher risk of AKI after high dose cisplatin chemotherapy.
A Multi-omics Study of Circulating Phospholipid Markers of Blood Pressure
Authors: Liu Jun , de Vries Paul S. , M. Fabiola Del Greco , Johansson Åsa , Schraut Katharina E. , Hayward Caroline , Dijk Ko Willems van , Franco Oscar. H. , Hicks Andrew A. , Vitart Veronique , Rudan Igor , Campbell Harry , Polašek Ozren , Pramstaller Peter P. , Wilson James F. , Gyllensten Ulf , Duijn Cornelia M. van , Dehghan Abbas , Demirkan Ayşe 
Published: June 2021

Abstract
Background High-throughput techniques allow us to measure a wide-range of phospholipids which can provide insight into the mechanisms of hypertension. We aimed to conduct an in depth multi-omics study of various phospholipids with systolic blood pressure (SBP) and diastolic blood pressure (DBP).Methods The associations of blood pressure and 151 plasma phospholipids measured by electrospray ionization tandem mass spectrometry were performed by linear regression in five European cohorts (n = 2,786 in discovery and n = 1,185 in replication). We further explored the blood pressure-related phospholipids in Erasmus Rucphen Family (ERF) study by associating them with multiple cardiometabolic traits (linear regression) and predicting incident hypertension (Cox regression). Mendelian Randomization (MR) and phenome-wide association study (pheWAS) were also explored to further investigate these association results.Results We identified six phosphatidylethanolamines (PE 38:3, PE 38:4, PE 38:6, PE 40:4, PE 40:5 and PE 40:6) and two phosphatidylcholines (PC 32:1 and PC 40:5) which together predicted incident hypertension with an area under the curve (AUC) of 0.61. The identified eight phospholipids are strongly associated with triglycerides, obesity related traits (e.g. waist, waist hip ratio, total fat percentage, body mass index, lipid-lowering medication, and leptin), diabetes related traits (e.g. glucose, insulin resistance and insulin) and prevalent type 2 diabetes. The genetic determinants of these phospholipids also associated with many lipoproteins, heart rate, pulse rate and blood cell counts. No significant association was identified by bi-directional MR approach.Conclusion We identified eight blood pressure-related circulating phospholipids that have a predictive value for incident hypertension. Our cross-omics analyses show that phospholipid metabolites in the circulation may yield insight into blood pressure regulation and raise a number of testable hypothesis for future research.
MIR17HG Polymorphisms Contribute to High Altitude Pulmonary Edema Susceptibility in Chinese Population
Authors: Si Lining , Wang Haiyuan , Wang Rong , Long Qifu , Zhao Yanli 
Published: June 2021

Abstract
Background: High-altitude pulmonary edema (HAPE) is a common acute altitude sickness. The results from existing studies have shown that the occurrence of HAPE is related to genetic factors. Therefore, six locis of MIR17HG were selected to study its effect on HAPE of Chinese population.Methods: All subjects were genotyped by the Agena MassARRAY, and the relationship between polymorphisms on MIR17HG and HAPE risk was evaluated using a χ2 test with an odds ratio (OR) and 95% confidence intervals (CIs) in multiple genetic models.Results: In the allele model, we observed that lower risk (OR = 0.74, p = 0.036) of the A allele for rs7318578 on the MIR17HG compared to the people with the C allele. Logistic regression analysis of four models for all selected MIR17HG SNPs between cases and controls showed significant differences for rs7318578 (OR = 0.74, p = 0.037) and rs17735387 (OR = 1.51, p = 0.036) in the HAPE population. Conclusion: Rs7318578 and rs17735387 on MIR17HG were associated with the genetic susceptibility of HAPE in Chinese population.
The Cost of Inappropriate Referral Pathways in Inpatient Care for Three Major Noncommunicable Diseases in Mongolia: A Registry-Based Analysis
Authors: Tuvdendorj Ariuntuya , Dechinkhorloo Otgonjargal , Dorjsuren Bayarsaikhan , Buskens Erik , Feenstra Talitha 
Published: June 2021

Abstract
Background: Non-communicable diseases (NCDs) consistently pose a huge economic burden to health systems and countries in general. The aim of this study was to quantify inpatient costs associated with chronic obstructive pulmonary disease, stroke and ischemic heart disease stratified by type of referral pathway, and to investigate key factors that drive these costs. Methods: A registry-based data analysis was performed using national public hospital inpatient records from 2016 to 2018 for 117,600 unique patients and linking patient-level inpatient health care use with hospital-specific unit cost per bed-day. These were combined to calculate the annual inpatient costs for each of the three disorders per person and per year. Generalized linear modeling was used to assess the association of inpatient costs with age, gender, location, comorbidity, treatment referral pathways and years.Results: Across three diagnoses, the majority of patients were female. Most were over 50-60 years old, with more than half being a pensioner, typically with at least one comorbidity. About 25% of patients followed what might be considered inappropriate (unofficial) inpatient referral pathways. Mean annual inpatient costs were int$ 721. These costs rose to int$ 849 for unofficial pathways and dropped to int$677 for official pathways. Further covariates significantly associated with high inpatient costs were location, age, gender, and comorbidity. Conclusion: Our findings provide background information essential to develop evidence-based and cost-effective interventions aimed at health promotion, prevention and service delivery. Reducing the unofficial use of inpatient care can improve efficient resource allocation in health care and prevent further escalation of inpatient costs in the future.
Synthesis of PANI@ZnO Hybrid Material and Evaluations in Adsorption of Congo Red and Methylene Blue Dyes: Structural Characterization and Adsorption Performance
Authors: Toumi Imane , Djelad Halima , Chouli Faiza , Abdelghani Benyoucef 
Published: June 2021

Abstract
In this research, a simple oxidation chemical process was applied for the synthesis of novel PANI@ZnO nanocomposite. The prepared nanocomposites were characterized by XPS, XRD, FTIR, SEM, TGA and N2 adsorption-desorption isotherms. Thereby, PANI@ZnO highest SBET values (about 40.84 m2.g− 1), total mesoporous volume (about 3.214 cm3.g− 1) and average pore size (about 46.12 nm). Afterwards, the prepared nanomaterial was applied as novel nanoadsorbent for the adsorption of Congo Red (CR) and Methylene Blue (MB) dyes from aqueous solutions at 298 K and pH 5.0. Besides, the pseudo-second-order model was obtained the best for the adsorption of both dyes. In the case of isotherm models, the Freundlich model showed the best fit. After removal, the spent adsorbent was regenerated. With the regeneration repeated five cycles, the PANI@ZnO regeneration efficiency remained at a very adequate level.
Cancer Treatments Using Low-Temperature Plasma
Authors: Tanaka Hiromasa , Mizuno Masaaki , Ishikawa Kenji , Toyokuni Shinya , Kajiyama Hiroaki , Kikkawa Fumitaka , Hori Masaru 
Published: June 2021

:
Low-temperature plasma (LTP) is a partially ionized gas that contains electrons,
ions, radicals, light, etc. Recently, the bio-medical application of LTP has become
a hot topic in plasma science and biological science. Cancer treatment with plasma is the
most challenging topic in plasma bio-medical applications. Many in vitro and in vivo experiments
have been conducted to investigate the anti-tumor effects of LTP. Extracellular
reactive oxygen and nitrogen species (RONS) in plasma-activated solutions are key factors
for the anti-tumor effects, and amino acid modifications by LTP may affect cellular
responses. Intracellular RONS are also key factors for the anti-tumor effects. Various signaling
pathways, such as p53 signaling pathways, survival and proliferation signaling
pathways, and oxidative stress-dependent signaling pathways are activated by LTP.
Oxypeucedanin is a Mechanism-based Inactivator of CYP2B6 and CYP2D6
Authors: Zhang Kehan , Li Yilin , Fu Yao , Cui Tiantian , Wang Qian , Mao Xu , Peng Ying , Zheng Jiang 
Published: June 2021

Background:
Herbal medicine Angelica dahurica is widely employed for the treatment of rheumatism and
pain relief in China. Oxypeucedanin is a major component in the herb.

Objectives :
The objectives of this study are aimed at the investigation of mechanism-based inactivation of CYP2B6
and CYP2D6 by oxypeucedanin, characterization of the reactive metabolites associated with the enzyme inactivation,
and identification of the P450s participating in the bioactivation of oxypeucedanin.

Methods :
Oxypeucedanin was incubated with liver microsomes or recombinant CYPs2B6 and 2D6 under designed
conditions, and the enzyme activities were measured by monitoring the generation of the corresponding products.
The resulting reactive intermediates were trapped with GSH and analyzed by LC-MS/MS.

Results :
Microsomal incubation with oxypeucedanin induced a time-, concentration-, and NADPH-dependent inhibition
of CYPs2B6 and 2D6 with kinetic values of KI/kinact 1.82 μM/0.07 min-1 (CYP2B6) and 8.47 μM/0.044 min-1
(CYP2D6), respectively. Ticlopidine and quinidine attenuated the observed time-dependent enzyme inhibitions. An
epoxide and/or γ-ketoenal intermediate(s) derived from oxypeucedanin was/were trapped in microsomal incubations.
CYP3A4 was the primary enzyme involved in the bioactivation of oxypeucedanin.

Conclusion :
Oxypeucedanin was a mechanism-based inactivator of CYP2B6 and CYP2D6. An epoxide and/or γ-
ketoenal intermediate(s) may be responsible for the inactivation of the two enzymes.
Cuantificación de bacterias nitrificantes en un suelo Typic melanudands en tres condiciones de uso de suelo en Pasto, Nariño, Colombia
Authors: Culchac Cuaran Lubi Yomaira , Estrada Marcillo Jhon Sebastián , Ordóñez Jurado Héctor Ramiro 
Published: June 2021

El presente estudio se realizó en el municipio de Pasto (Nariño, Colombia), con el fin de estimar la cantidad de bacterias oxidadoras de amonio (BOA) y bacterias oxidadoras de nitrito (BON), en tres usos del suelo (bosque secundario, pastura tradicional y sistema silvopastoril) a dos profundidades (0-10 y 10-20 cm). Para ello, se utilizó un diseño experimental completamente al azar (DCA), con seis tratamientos y tres repeticiones, para un total de 18 unidades experimentales; para su estimación, se utilizó la técnica del número más probable (NMP). El análisis de varianza mostró diferencias estadísticas altamente significativas para usos y profundidades del suelo en BOA. La pastura tradicional presentó la mayor densidad de BOA a una profundidad de 0-10 cm: 8,8 × 104 UFC/g, y el bosque presentó menor densidad: 1,3 × 103 UFC/g. En BON, la mayor densidad poblacional se encontró en pastura: 9,4 × 103 UFC/g, y el bosque presentó menor densidad: 3,8 × 103 UFC/g. La mayor densidad de bacterias se presentó de 0 a 10 cm en BOA: 3,7 × 103 UFC/g, mientras que para BON fue de 7,3 × 103 UFC/g, debido posiblemente a que en los primeros 5 cm del suelo se encuentra la capa biológicamente más activa. Las mayores densidades de bacterias nitrificantes encontradas en los usos de suelo: pastura tradicional y sistema silvopastoril, pudieron estar relacionadas con las fertilizaciones orgánicas, reincorporación del estiércol y orina de los animales, que son un sustrato ureico promotor de crecimiento de microorganismos.
Alignment of Key Stakeholders’ Priorities for Patient-Facing Tools in Digital Health: Mixed Methods Study
Authors: Lyles Courtney Rees , Adler-Milstein Julia , Thao Crishyashi , Lisker Sarah , Nouri Sarah , Sarkar Urmimala 
Published: June 2021

Background
There is widespread agreement on the promise of patient-facing digital health tools to transform health care. Yet, few tools are in widespread use or have documented clinical effectiveness.

Objective
The aim of this study was to gain insight into the gap between the potential of patient-facing digital health tools and real-world uptake.

Methods
We interviewed and surveyed experts (in total, n=24) across key digital health stakeholder groups—venture capitalists, digital health companies, payers, and health care system providers or leaders—guided by the Consolidated Framework for Implementation Research.

Results
Our findings revealed that external policy, regulatory demands, internal organizational workflow, and integration needs often take priority over patient needs and patient preferences for digital health tools, which lowers patient acceptance rates. We discovered alignment, across all 4 stakeholder groups, in the desire to engage both patients and frontline health care providers in broader dissemination and evaluation of digital health tools. However, major areas of misalignment between stakeholder groups have stymied the progress of digital health tool uptake—venture capitalists and companies focused on external policy and regulatory demands, while payers and providers focused on internal organizational workflow and integration needs.

Conclusions
Misalignment of the priorities of digital health companies and their funders with those of providers and payers requires direct attention to improve uptake of patient-facing digital health tools and platforms.
Mobile Technology Access and Use Among Adolescent Mothers in Lima, Peru: Mixed Methods Study
Authors: Levey Elizabeth J , Onyeaka Henry , Bartles Sophia M , Sanchez Calderon Elena , Sanchez Sixto E , Prom Maria C , Fesseha Eden M , Gelaye Bizu 
Published: June 2021

Background
Research shows promise for the use of mobile health interventions to improve access to care for mothers and infants. Although adolescent mothers in particular are comfortable with technology and often face barriers to accessing care, data on the use of digital interventions with young mothers are limited.

Objective
This study aims to examine technology access and use behavior among adolescent mothers in Lima, Peru, to inform the development of technology-mediated perinatal interventions for high-risk mothers and infants in low- and middle-income countries and other areas with limited access to care.

Methods
This mixed methods study consisted of a phone survey about technology access (N=29), focus group discussions with clinicians (N=25), and semistructured in-depth interviews with adolescent mothers (N=10) and their family members (N=8) in Lima.

Results
All adolescent mothers surveyed had access to a smartphone, and nearly half had access to a computer or tablet. However, participants reported a number of obstacles to consistent smartphone access related to the financial precarity of their situations. Examples of this included difficulty affording phone services, using shared plans, and losing smartphones because of theft.

Conclusions
These findings indicate that adolescent mothers are connected to technology, highlighting the potential scalability of technology-based health interventions for adolescent mothers in low- and middle-income countries while identifying barriers that need to be addressed.
Evaluation of patient/caregiver and healthcare provider knowledge, attitudes and behavior for safety and use of pexidartinib
Authors: Salas Maribel , Julian Michele , Choi Youngsook , Islam Zahid , Henderson Mackenzie , Stemhagen Annette , O'Donnell Natalie , Tu Nora 
Published: June 2021

Aim:
Pexidartinib was approved for the treatment of tenosynovial giant cell tumors with a required Risk Evaluation and Mitigation Strategy (REMS) to ensure its safe use. As required by the REMS, a survey was conducted to document the knowledge, attitudes and behavior (KAB) of patients/caregivers and healthcare providers (HCPs) regarding the risk of serious and potentially fatal liver injury due to pexidartinib, the need for liver testing prior to and during treatment and the need for patient counseling about this risk.
Patients & methods:
The KAB survey was conducted among 40 patients and 18 HCPs enrolled in the pexidartinib REMS.
Results:
Among patients, 87.5% demonstrated understanding of key risk message (KRM) 1 (risk of serious liver injury), 87.5% demonstrated understanding of KRM2 (liver testing requirement) and 77.5% demonstrated understanding of both KRMs. Among HCPs, 83.3% demonstrated understanding of KRM1, 88.9% demonstrated understanding of KRM2, 100% demonstrated understanding of KRM3 (patient counseling) and 83.3% demonstrated understanding of all three KRMs.
Conclusion:
The KAB surveys demonstrated that the educational goals of the pexidartinib REMS were being achieved.
Konvencijas par uzņēmējdarbību un cilvēktiesībām nepieciešamība
Authors:   Latvijas Universitātes Juridiskā fakultāte, Birģelis Mārtiņš 
Published: June 2021

The current legal framework does not properly address the impact that transna­tional corporations have on human rights. In 2014, the UN Human Rights Council established an open-ended intergovernmental working group with a mandate to elaborate an international legally binding instrument to regulate the activities of transnational corporations and other business enter­prises. Yet this decision was strongly contested. This article outlines the main arguments for desirability of an international treaty on business and human rights and provides a response to some of the most common objections raised against the development of such legally binding instrument.
Tiesas jurisdikcija saskaņā ar Konvenciju par kravu starptautisko autopārvadājumu līgumu (CMR)
Authors:   Rīgas Juridiskā Augstskola, Fillers Aleksandrs ,   Latvijas Universitāte
Published: June 2021

Convention on the Contract for the International Carriage of Goods by Road (CMR) is one of the leading conventions containing uniform private law rules. Most of its rules are substantive and regulate different aspects of the international contract of carriage. However, the CMR also contains jurisdictional rules. The article is intended as a short commentary on Article 31(1) CMR that establishes a rather specific jurisdictional regime for disputes arising from international contracts of carriage. Every time when a court faces a dispute related to a contract of carriage covered by the CMR, it must establish its jurisdiction. Thus, it is particularly important to clarify the most important issues concerning the application of Article 31(1) CMR.
Noilguma regulējums Latvijas civiltiesībās
Authors:   Rīgas Juridiskā Augstskola, Fillers Aleksandrs ,   Latvijas Universitāte
Published: June 2021

Extinctive prescription is a universally recognized mechanism to terminate obligations. However, every legal system must determine whether the extinctive prescription functions automatically (ipso iure) or does it grant a debtor a right to refuse the performance of prescribed obligations. The author argues that in Latvia the extinctive prescription must be functioning as an objection that the debtor may make to refuse the performance of an obligation. This necessarily implies that a court cannot raise the extinctive prescription unless it is invoked by the debtor.
Aizdevuma līguma priekšlīguma regulējuma mijiedarbība ar apstākļu izmaiņu klauzulu
Authors: Pavlovskis Germans 
Published: June 2021

The article provides a scientific insight into the sources of Article 1935 of the Civil Law of the Republic of Latvia and their role in the development of the preliminary loan contract regulation, paying particular attention to the influence of pandectism. It compares the differences between legal consequences of concluding a preliminary loan contract and a preliminary contract regulated in Article 1541 of the Civil Law of the Republic of Latvia. The article concludes that the binding force of the preliminary loan contract shall be linked to the reservation of the changed circumstances clause.
Gribas izpauduma nozīme tiesiska darījuma noslēgšanā
Authors:   Latvijas Universitātes Juridiskā fakultāte, Kadile Laura 
Published: June 2021

The expression of will is a crucial aspect of lawful transaction in civil law. The will of the individual and its expression is significant in ensuring for the ability of an individual to enjoy and exercise his or her right to self-determination, as well as for the legal transaction to be recognized as valid. Only the transactions made by a person capable of expressing their free will and being able to be aware of the content and consequences of the legal transaction are in force. Therefore, the observation and assessment of such capacity is particularly important in view of the fact that, in circumstances where a person is unable to express his will freely, he may be denied the right to enter into a legal transaction, or, if the legal transaction has been concluded in circumstances where the individual has not been able to express free will, such transaction may be declared invalid.
Valsts nodevas regulējuma atsevišķie aspekti un prakses īpatnības civilprocesā
Authors:   Latvijas Universitātes Juridiskā fakultāte, Ose Daina 
Published: June 2021

This work reviews the questions related to state fee and court cost reim­bursement. One of the analysed issues is an obligation to review state fee in a defined period of time in order to ensure the basis for state fee regulation and its adequacy to the economic situation in the state. The second question is related to the exhaustive list of cases in the legal norm when person in the status of defendant has been made exempt from court cost reimbursement. In practice, identifying the need to define new cases, an application of those is allowed by introducing relevant changes into the legal norm.
Sporta preču zīmes
Authors:   Zvērinātu advokātu birojs “BDO Law”, Kaprāne Stella 
Published: June 2021

The aim of the current article is to define sports trademarks concept, various types of sports trademarks, their Nice classification classes, preconditions for the imple­mentation of sports trade mark protection, as well as to bring to attention other relevant questions connected with trademark protection, such as the domain name protection. In preparation of the article, the author has studied court rulings, legal literature, various normative acts regarding trade marks and their protection. The applied methods include comparative method, analytical method, deduction and induction methods.