bluuebunny/crossref_metadata_2025_split huggingface dataset:
EDUKASI PENGGUNAAN PROBIOTIK YANG TEPAT SEBAGAI IMUNOSTIMULAN DI ERA PANDEMI COVID-19
Authors: Mawardika Herlinda , Oktavia Ira 
Published: May 2021

ABSTRAKPandemi COVID-19 adalah salah satu masalah utama yang sedang dihadapi masyarakat karena memberikan dampak yang besar di bidang kesehatan maupun perekonomian. Dalam mengatasi infeksi COVID-19, masyarakat dianjurkan untuk menerapkan protokol kesehatan seperti memakai masker, menjaga jarak, cuci tangan dengan sabun, serta menjaga imunitas tubuh melalui olahraga dan konsumsi makanan atau minuman yang baik untuk kesehatan. Selain jamu, probiotik dapat menjadi pilihan yang tepat untuk dikonsumsi selama pandemi COVID-19. Probiotik adalah kultur mikroba hidup yang baik untuk sistem pencernaan dan diketahui berperan dalam mempengaruhi sistem imun tubuh. Probiotik dapat diperoleh dari produk-produk fermentasi. Kegiatan pengabdian masyarakat ini bertujuan memberikan informasi kepaa masyarakat tentang penggunaan probiotik yang tepat untuk peningkatan imunitas tubuh di era pandemi COVID-19. Kegiatan ini dilakukan melalui sosialisasi di Desa Duwet Kabupaten Malang. Keberhasilan pengabdian masyarakat ditentukan dari penilaian kuesioner yang diberikan ke peserta. Hasil evaluasi kegiatan menunjukkan bahwa pengabdian kepada masyarakat ini berlangsung dengan baik dan dapat mencapai tujuan yang diharapkan, yaitu sosialisasi dapat meningkatan pemahaman dan kesadaran peserta untuk mengkonsumsi probiotik.Kata Kunci: Probiotik, Imune system, COVID-19 ABSTRACTPandemic COVID-19 is one of the main problems faced by society because it causes a huge impact in the field of health and economy. In overcoming the infection of COVID-19, people are encouraged to apply health protocols such as wearing mask, keeping a distance, washing hands with soap, as well as maintaining the immunity of the body through exercise and the consumption of foods or drinks that are good for health. In addition to herbs, probiotics can be the right choice to be consumed during the pandemic COVID-19. Probiotics are cultures of live microbes that are good for digestive system and have been found to influence the immune system. Probiotics can be obtained from the fermentation products. The objective of this community service was to provide information for the public about the proper use of probiotic to increase the body's immunity in the era of pandemic COVID-19. This activity was carried out by socialization in Duwet Village Malang Regency. The success of the community is determined based on the assessment of participants’questionnaire. The results showed that this community service was going well and achieved the expected goal, socialization increased participants’ awareness and understanding of probiotic consumption. Keywords: Probiotics, Immune system, COVID-19
Pengaruh Fungsi Kepemimpinan Kompensasi dan Kepuasan Kerja Terhadap Kinerja Pegawai Dinas Lingkungan Hidup Kota Cimahi
Authors: Indrawanto Setya 
Published: May 2021

Penelitian Ini Berjudul “Pengaruh Fungsi Kepemimpinan Kompensasi Dan Kepuasan Kerja Terhadap Kinerja Pegawai Dinas Lingkungan Hidup Kota Cimahi. Tujuan Penelitian Ini Untuk Menganalisis Pengaruh Fungsi kepemimpinan, kopensasi terhadap Kepuasan Kerja, Pengaruh Fungsi Kepemimpinan Konpensasi Dan Kepuasam Terhadap Pegawai. Penelitian Menggunakan Analisis Jalur, {Path Analisis|}. Populasi Penelitian Ini Adalah 50 ASN Kota Cimahi Tahun 2018 Dengan Jumlah Sample Sebanyak 50 Orang Yang Dengan System Probalitiy Sampel, Setiap Populasi Bisa Dijadikan Sampel. Hasil Penelitian Menunjukkan Fungsi Kepemimpinan, Kompensasi Dan Kepuasan Kerja Mempengaruhi Kinerja Pegawai Secara Positif Dan Signifikan Dengan Nilai T Hitung Masing-Masing Untuk Fungsi Kepemimpinan = 0.577, Kompensasi= 0.303, Dan Kepuasan= 0,293 Dimana Nilai T Hitung > T Tabel Dan Nilai Nilai Signifikansi Kurang Dari 0,05. Nilai R2 Sebesar 0,807 Artinya Nilai Koefisien Determinasi = 80,7 %.Maknanya Fungsi Kepemimpinan, Kompensasi, Kepuasan Memberikan Kontribusi Untuk Mempengaruhi Kinerja Pegawai Sebesar 80,7 %.Persamaan Analisis Jalur Y= Ρyx1x1 + Ρyx2x2 + Ρyx3x3 + Ε.Y= 0,577 X1 + 0,303 X2 + 0, 293 X3 + 0,193 Ε. Berdasarkan hasil temuan ini maka perlu dilakukan upaya-upaya untuk meningkatkan kinerja pegawai yang dapat dilakukan dengan melakukan usaha yang terarah dan terpadu serta dilaksanakan dengan konsisten dan berkesinambungan agar dapat mencapai kepuasan kerja sehingga dapat mempengaruhi kinerja karyawan.
The intervention of artificial intelligence in the recruitment function in UAE’s hospitality industry
Authors: Pandya Bharti , Al Janahi Maryam Mohammed 
Published: May 2021

Artificial Intelligence (AI) is not a new concept for Hospitality Industry and Recruitment functions. AI has displaced the human intervention in routine tasks. In few years, AI will take over several jobs (Kubler, 2018). Recently AI technologies support application screening, data analysis, and preliminary interviews, saving time of recruiters. Chatbots are now designated recruitment officers supporting candidates. Researchers have studied the influence of AI on Recruitment, but only a few focused on the AI displacing human in the recruitment function performed in UAE’s hospitality industry.
This research aims to understand the transformation in the recruitment function of UAE’s hospitality industry due to AI intervention. Using concurrent mixed-methods, data was collected by interviewing 10 UAE HR leaders and surveying 135 HR professionals. The inductive-deductive thematic analysis was conducted for subjective measures and descriptive analysis was performed for scaled measures.
This study found that UAE’s hospitality sector deployed AI technologies in recruitment areas such as job advertisements, collecting applications, maintaining profiles, and storing the applications. The routine, repetitive, and heavy-volume tasks in the recruitment are delegated to AI while strategic roles are retained for human professionals including development of strategies, and creation of job descriptions and specifications. While the literature review suggested a wider application of AI in recruitment function, UAE’s hospitality sector seems to be lagging. The recommendations will benefit industry leaders, HR professionals, recruitment consultants, and AI developers to rethink on the recruitment strategies, operations, and administration and to embrace the intervention of AI in recruiting the best talent proficiently.
Capacitación Pedagógica en Herramientas Digitales y su Impacto en la Calidad Educativa de las Instituciones Educativas Fiscales en época de Pandemia
Authors: Campoverde-Luque Rosa , Ponce-Ardila Jenifer , Rivera-Macías Gina 
Published: May 2021

La Capacitación Pedagógica en herramientas digitales en época de pandemia, debe ser una actividad constante y permanente, que comprometa tanto al docente como al estudiante, en su rol de mejorar y efectivizar el proceso de enseñanza y aprendizaje, ya que se busca reforzar y actualizar los conocimientos adquiridos en su carrera profesional, con el fin de construir nuevas estrategias de enseñanza en el salón de clases, ahora virtuales. La falta de capacitación dentro de los procesos educativos, principalmente en el área didáctica – pedagógica, provoca en los estudiantes desmotivación, poco deseo de aprender, debido a lo rutinario de las clases, por ello es relevante que todos los docentes que conforman el sistema educativo nacional cumplan con la responsabilidad de abordar nuevos temas en el marco educativo, para mejorar sus competencias, enmarcadas en posibilitar la llamada calidad educativa. El Objetivo del análisis es proponer un proceso de aula virtual que permita fortalecer los conocimientos previos a través del aprendizaje compartido y uso de herramientas digitales, y que logren generar conocimientos significados y habilidades competitivas. La metodología aplicada es de corte teórico, se analizaron aproximadamente 30 artículos publicados desde el 2012 hasta la presente fecha, tanto empíricos , como teóricos, y la revisión literaria está enfocada en temas como: la capacitación pedagógica, herramientas digitales, calidad educativa, formación docente y aprendizaje, en base de datos de google academics, revista Elsevier, Redalyc, Scielo, Dialnet y otras. Los hallazgos encontrados dan relevancia a la capacitación pedagógica en metodologías innovadoras y herramientas digitales como You Tube, Educreations, Quizziz, Kahoot, Google Meet; además de pizarras y murales virtuales, tales como Padlet, Visual Thinking etc, ya que estos recursos son herramientas imprescindibles en los procesos de mejoramiento de métodos y estrategias de enseñanza y aprendizaje, y que tienen gran impacto en la calidad educativa.
Representações dos profissionais da saúde pública sobre as práticas integrativas e complementares na Cidade de Viçosa-MG, Brasil
Authors: Andrade Marco Paulo , Doula Sheila Maria , Vieira João Paulo Louzada , Ribeiro Isadora Moreira 
Published: May 2021

O artigo tem como objetivo analisar as representações de profissionais de saúde pública do município de Viçosa - MG acerca das Práticas Integrativas e Complementares (PICs). A metodologia é de natureza qualitativa. Partindo-se do histórico de institucionalização política dessas práticas, utiliza-se a Teoria das Representações Sociais para análise das entrevistas. Os resultados se organizam em dois eixos temáticos, os quais tratam do conhecimento e aceitação das práticas integrativas e da inserção das benzedeiras no SUS. Observa-se que os profissionais desconhecem a Política Nacional de Práticas Integrativas e Complementares, mas reconhecem as práticas por ela abrangidas. Conclui-se que a ineficiência na divulgação da política influencia as percepções sobre sua eficácia e possibilidade de serem executadas.
Ansiedade dos familiares de crianças cardiopatas na fase pré-operatória: Reflexões a respeito da atuação do enfermeiro
Authors: Melo Laércio Deleon de , Souza Aline Aparecida Goulart de , Magalhães Diego Monteiro , Coelho Gabriela Bittencourt , Oliveira Sarah Quezia Lopes de , Pereira Rosiane de Jesus , Taroco Felipe Eduardo , Marques Roberta Lopes 
Published: May 2021

Objetivou-se refletir sobre as estratégias utilizadas pelo enfermeiro no controle da ansiedade dos familiares no período pré-operatório de cirurgias cardíacas pediátricas. O delineamento adotado foi uma revisão integrativa, cujo período de busca ocorreu entre os meses de agosto-outubro/2020 de artigos indexados a partir de 2010 em bases de dados. Foram selecionados para esta investigação e inclusos 16 artigos, sendo a síntese do conhecimento apresentada em duas categorias: 1) Assistência multiprofissional e interdisciplinar na abordagem das cardiopatias congênitas - retratou a assistência de abordagem multidimensional e em equipe às cardiopatias e 2) Ações de prevenção e controle da ansiedade dos familiares executadas na fase pré-operatória das cardiopatias congênitas como estratégia no cuidar em enfermagem – abordou as ações de enfermagem voltadas ao controle da ansiedade. As estratégias comunicacionais e de acolhimento com a escuta sensível, humanizada e qualificada devem ser permeadas por ações educativas em saúde em prol da promoção do bem-estar e do controle da ansiedade a partir da aceitação da doença, das limitações da criança, bem como das formas de tratamento adotadas. São peças fundamentais na relação terapêutica da tríade enfermeiro/criança/familiares e configuram-se como importantes eixos estruturantes do planejamento do cuidado de enfermagem.
Case Report: Phloroglucinol-Induced Kounis Syndrome
Authors: Wu Hao-Yu , Gao Tian-Jiao , Cao Yi-Wei , You Peng-Hua 
Published: May 2021

Background: Kounis syndrome is an allergy-related acute coronary syndrome that is induced by various pharmacological and environmental factors. Given that many clinicians are not aware of this condition, many cases may be underdiagnosed. We report a case of type II Kounis syndrome induced by phloroglucinol.Case Summary: A 52-year-old man with pre-existing coronary artery stenosis presented with a 30-min history of chest pain and erythematous rash after intramuscular administration of phloroglucinol. An electrocardiogram demonstrated ST-segment elevation in leads II, III and aVF. Emergency coronary angiography revealed severe stenosis in the distal right coronary artery. Intravascular ultrasound showed plaque rupture and thrombosis, and the minimum lumen area was 3.0 mm2. A 3.5 × 38 mm stent was implanted in the distal right coronary artery. Troponin I levels were elevated. A diagnosis of type II Kounis syndrome induced by phloroglucinol was made, and the condition manifested as acute ST-segment elevation myocardial infarction.Conclusions: Clinicians should be aware of Kounis syndrome as a possible diagnosis in a patient who presents with chest pain and allergic manifestations given that an increasing number of triggers are being reported.
Persistent Symptoms and Health Needs of Women and Men With Non-Obstructed Coronary Arteries in the Years Following Coronary Angiography
Authors: Groepenhoff Floor , Eikendal Anouk L. M. , Rittersma Z. H. Saskia , Gijsberts Crystel M. , Asselbergs Folkert W. , Hoefer Imo E. , Pasterkamp Gerard , Rutten Frans H. , Onland-Moret N. Charlotte , Den Ruijter Hester M. 
Published: May 2021

Background: The prognosis of women and men with persistent anginal complaints and non-obstructed coronary arteries is impaired as compared with asymptomatic women and men. The increased healthcare burden in the hospital due to repeated coronary angiography in these women and men has been documented, yet little is known about the percentage of women and men who remain symptomatic and under care of the general practitioner in the years following a coronary angiographic outcome of non-obstructed coronary arteries.Methods: From the Utrecht Coronary Biobank study, including individuals who underwent a coronary angiography from 2011 to 2015 (N = 2,546, 27% women), we selected women and men with non-obstructed coronary arteries (N = 687, 39% women). This population was linked to the Julius General Practitioners Network (JGPN); a database with routine care data of general practitioners. For every individual with non-obstructed coronary arteries, we selected an asymptomatic non-referred age-, sex-, and general practitioner-matched individual from the JGPN. We compared the healthcare consumption of men and women with non-obstructed coronary arteries to these matched individuals. The McNemar's test was used for pairwise comparison, and sex differences were assessed using stratified analyses.Results: The prevalence of non-obstructed coronary arteries was higher in women as compared with men (39 vs. 23%). During a median follow-up of 7 years [IQR 6.4–8.0], 89% of the individuals with non-obstructed coronary arteries (91% women and 87% men) visited their general practitioner for one or more cardiovascular consultations. This was compared to 34% of the matched individuals (89 vs. 34%, p &lt; 0.001). The consultations were most often for angina (equivalents) (57 vs. 11%, p &lt; 0.001) and heart failure (10 vs. 2%, p = 0.015). In addition, they more often consulted the general practitioner for psychosocial complaints (31 vs. 15%, p = 0.005). Findings were similar for women and men.Conclusions: A coronary angiographic outcome of non-obstructed coronary arteries is more common in women than in men. In the years following the coronary angiography, the majority of the population remains symptomatic. Both women and men with non-obstructed coronary arteries had higher health needs for angina, heart failure, and psychosocial complaints than matched asymptomatic individuals.
Increased Dysfunctional and Plastic Regulatory T Cells in Idiopathic Orbital Inflammation
Authors: Chen Jingqiao , Ye Huijing , Xiao Wei , Mao Yuxiang , Ai Siming , Chen Rongxin , Lian Xiufen , Shi Lu , Wang Xing , Bi Shaowei , Yang Shenglan , Ji Xian , Zhang Te , Yang Huasheng 
Published: May 2021

BackgroundIdiopathic orbital inflammation (IOI) is a disfiguring and vision-threatening fibroinflammatory disorder. The pathogenesis of IOI has not been elucidated. We sought to clarify the regulatory T cell (Treg) distribution and function in patients with IOI.MethodsThe frequency, phenotype and function of Tregs were identified by multicolor flow cytometry andin vitrocell functional assays. Plasma and tissue samples were obtained to investigate cytokines, chemokines and their receptors of interest by relative real-time polymerase chain reaction (PCR) and Luminex assays.ResultsCompared with healthy subjects, patients with IOI exhibited obvious increases of Tregs in peripheral blood and affected orbital tissues. Circulating Tregs from patients with IOI were significantly more polarized to a Th17-like phenotype with defective regulatory function, whereas orbit-derived Tregs were polarized to a Th2-like phenotype. Furthermore, ST2 expression levels in circulating Tregs and interleukin (IL)-33 mRNA levels in orbital tissues were decreased in IOI. IL-33 restored the suppressive function of Tregs, reduced interferon (IFN)-γ production by Tregs and decreased the activation of orbital fibroblasts (OFs) cocultured with Tregs in IOI.ConclusionIncreased Tregs with proinflammatory and profibrotic polarization were first identified in IOI, suggesting that Treg plasticity and heterogeneity plays an essential role in IOI pathogenesis. Additionally, our study identified a regulatory effect of IL-33 on inflammation and fibrosis in IOI. Reversing the plastic TregsviaIL-33 might be a potential option for IOI patients.
Clozapine Regulates Microglia and Is Effective in Chronic Experimental Autoimmune Encephalomyelitis
Authors: Ceylan Ulaş , Haupeltshofer Steffen , Kämper Laura , Dann Justus , Ambrosius Björn , Gold Ralf , Faissner Simon 
Published: May 2021

ObjectiveProgressive multiple sclerosis is characterized by chronic inflammation with microglial activation, oxidative stress, accumulation of iron and continuous neurodegeneration with inadequate effectiveness of medications used so far. We now investigated effects of iron on microglia and used the previously identified neuroprotective antipsychotic clozapine in vitro and in chronic experimental autoimmune encephalomyelitis (EAE).MethodsMicroglia were treated with iron and clozapine followed by analysis of cell death and response to oxidative stress, cytokine release and neuronal phagocytosis. Clozapine was investigated in chronic EAE regarding optimal dosing and therapeutic effectiveness in different treatment paradigms. Animals were scored clinically by blinded raters. Spinal cords were analyzed histologically for inflammation, demyelination, microglial activation and iron accumulation and for transcription changes of regulators of iron metabolism and inflammation. Effects on immune cells were analyzed using flow cytometry.ResultsIron impaired microglial function in vitro regarding phagocytosis and markers of inflammation; this was regulated by clozapine, reflected in reduced release of IL-6 and normalization of neuronal phagocytosis. In chronic EAE, clozapine dose-dependently attenuated clinical signs and still had an effect if applied in a therapeutic setting. Early mild sedative effects habituated over time. Histologically, demyelination was reduced by clozapine and positive effects on inflammation strongly correlated with reduced iron deposition. This was accompanied by reduced expression of DMT-1, an iron transport protein.ConclusionsClozapine regulates microglial function and attenuates chronic EAE, even in a therapeutic treatment paradigm. This well-defined generic medication might therefore be considered as promising add-on therapeutic for further development in progressive MS.
The Impact of Intraoperative Frozen Section on Resection Margin Status and Survival of Patients Underwent Pancreatoduodenectomy for Distal Cholangiocarcinoma
Authors: Chen Zhiqiang , Yu Bingran , Bai Jiaping , Li Qiong , Xu Bowen , Dong Zhaoru , Zhi Xuting , Li Tao 
Published: May 2021

BackgroundIntraoperative frozen section (FS) is broadly used during pancreaticoduodenectomy (PD) to ensure a negative margin status, but its survival benefits on obtaining a secondary R0 resection for distal cholangiocarcinoma (dCCA) is controversial and unclear.MethodsClinical data of 107 patients who underwent PD for dCCA was retrospectively collected and divided into different groups based on use of FS (FS and non-FS groups) and status of resection margin (pR0, sR0 and R1 groups), and clinical parameters and survival of patients were compared and analyzed accordingly.ResultsThere were 50 patients in FS group with a median survival of 28 months, 57 patients in non-FS group with a median survival of 27 months. There was no statistical difference between the two groups with Kaplan-Meier survival analysis (P = 0.347). There were 98 patients in R0 group (88 in pR0 and 10 in sR0) and nine patients in R1 group, with a median survival of 29 months and 22 months respectively, which showed a better survival in R0 group than in R1 group (P = 0.006). Survival analyses between subgroups revealed difference between pR0 and R1 group (P = 0.005), while no statistical difference concerning pR0 vs. sR0 (P = 0.211) and sR0 vs. R1 groups (P = 0.262). Multivariate Cox regression analysis revealed resection margin status, pre-operative biliary drainage and lymph node invasion to be independent prognostic factors for dCCA patients.ConclusionsIntraoperative FS should be recommended as it significantly increased the rate of R0 resection, which was positively related to a better survival. A primary R0 resection should also be encouraged and if not, a secondary R0 could be considered at the discretion of surgeons as it showed similar survival with primary R0 resection.
Hypoxia-Induced MALAT1 Promotes the Proliferation and Migration of Breast Cancer Cells by Sponging MiR-3064-5p
Authors: Shih Chung-Hsien , Chuang Li-Ling , Tsai Mong-Hsun , Chen Li-Han , Chuang Eric Y. , Lu Tzu-Pin , Lai Liang-Chuan 
Published: May 2021

Hypoxia, a common process during tumor growth, can lead to tumor aggressiveness and is tightly associated with poor prognosis. Long noncoding RNAs (lncRNAs) are long ribonucleotides (&gt;200 bases) with limited ability to translate proteins, and are known to affect many aspects of cellular function. One of their regulatory mechanisms is to function as a sponge for microRNA (miRNA) to modulate its biological functions. Previously, MALAT1 was identified as a hypoxia-induced lncRNA. However, the regulatory mechanism and functions of MALAT1 in breast cancer are still unclear. Therefore, we explored whether MALAT1 can regulate the functions of breast cancer cells through miRNAs. Our results showed the expression levels of MALAT1 were significantly up-regulated under hypoxia and regulated by HIF-1α and HIF-2α. Next, in contrast to previous reports, nuclear and cytoplasmic fractionation assays and fluorescence in situ hybridization indicated that MALAT1 was mainly located in the cytoplasm. Therefore, the labeling of MALAT1 as a nuclear marker should be done with the caveat. Furthermore, expression levels of miRNAs and RNA immunoprecipitation using antibody against AGO2 showed that MALAT1 functioned as a sponge of miRNA miR-3064-5p. Lastly, functional assays revealed that MALAT1 could promote cellular migration and proliferation of breast cancer cells. Our findings provide evidence that hypoxia-responsive long non-coding MALAT1 could be transcriptionally activated by HIF-1α and HIF-2α, act as a miRNA sponge of miR-3064-5p, and promote tumor growth and migration in breast cancer cells. These data suggest that MALAT1 may be a candidate for therapeutic targeting of breast cancer progression.