bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring treatment effect on psoriatic arthritis-related domains: insights from the SPIRIT-H2H study at weeks 24 and 52
Authors: Behrens Frank , Leage Soyi Liu , Sapin Christophe , Baou Celine El , De La Torre Inmaculada , Meszaros Gabriella , Schett Georg , Combe Bernard , van den Bosch Filip , Gossec Laure 
Published: September 2021

Abstract
Introduction
Improvements in both musculoskeletal and non-musculoskeletal manifestations are important treatment goals in psoriatic arthritis (PsA).

Objective
These post hoc analyses determined whether additional benefits related to various PsA domains are observed in patients simultaneously achieving 50% improvement in American College of Rheumatology criteria (ACR50) and 100% improvement in Psoriasis Area Severity Index (PASI100), the primary endpoint of the SPIRIT-H2H study.

Methods
Patients with active PsA and psoriasis in SPIRIT-H2H (N = 566) were categorised into two sets of four response groups irrespective of treatment allocation (approved dosages of ixekizumab or adalimumab): patients who simultaneously achieved ACR50 and PASI100 response, achieved ACR50 response only, achieved PASI100 response only, or did not achieve ACR50 or PASI100 response after 24 and 52 weeks of treatment. Patients achieving simultaneous ACR50 and PASI100 response were compared with the other patient response groups at the corresponding time point for efficacy and health-related quality of life (HRQoL) outcomes.

Results
Patients simultaneously achieving ACR50 and PASI100 responses at week 24 or 52 showed higher rates of ACR70 response, minimal disease activity, Disease Activity in Psoriatic Arthritis ≤ 4, resolution of enthesitis and dactylitis, and HRQoL improvement at weeks 24 and 52, respectively, than the other corresponding response groups at both time points.

Conclusion
High levels of disease control, such as those obtained with simultaneous achievement of ACR50 and PASI100 response, were linked to better outcomes across a wide range of endpoints that are important for patients with PsA. Patients meeting this combined endpoint showed more comprehensive and thus greater control of disease activity.
Trial registration
NCT03151551

Key Points• Treatment goals for patients with psoriatic arthritis emphasise the importance of improving both musculoskeletal and non-musculoskeletal manifestations of the disease.• A combined endpoint considering both these manifestations, achievement of at least 50% improvement in American College of Rheumatology criteria and 100% improvement in Psoriasis Area Severity Index, was linked with achievement of a number of other endpoints relevant to psoriatic arthritis, including health-related quality of life that are important to patients with psoriatic arthritis.• Patients meeting the combined endpoint were more likely to achieve a disease state of remission, which is the stated aim of treatment for psoriasis.
Examining the role of emotional intelligence as a moderator for virtual communication and decision making effectiveness during the COVID-19 crisis: revisiting task technology fit theory
Authors: Warrier Uma , Shankar Anand , Belal H. M. 
Published: September 2021

AbstractThe COVID 19 has brought unprecedented changes in the way we communicate. There is a greater accent on Virtual communication. This paper aims to establish a relationship between Emotional intelligence and the effectiveness of Virtual communication on Decision making. This empirical study is based on a sample drawn from 296 working professionals at five different levels of organizational hierarchy. A standardized questionnaire (ɑ = 0.824) was used to collect the responses of Emotional intelligence, Virtual communication, and Decision-making effectiveness. Hierarchical regression using PROCESS Macro model 1 was used to identify the moderating effect of Emotional intelligence on Virtual communication and Decision making effectiveness. Since thep-value (p ≤ .007) is found significant, Emotional intelligence acts as a moderator that affects the strength of the relationship between Virtual communication effectiveness and Decision making. Validation of Task Technology fit theory is the theoretical implication of the study. Manipulation of individual dimensions in the model can reduce the dependence on technology for task completion with enhanced performance effectiveness. The findings are relevant to educators, consultants, and any professional who need to adapt Virtual communication platforms on an ongoing basis. Since work-life balance is projected as a constraint in this study, policymakers can consider policy amendments to reduce the stress caused due to Virtual communication which intrudes into their personal space. This empirical study is the first of its kind to benchmark the organizational practice of Emotional intelligence training to enhance Virtual communication and Decision making effectiveness during unprecedented times of pandemic.
Reversal and Inversion of Capillary Jet Breakup at Large Excitation Amplitudes
Authors: Denner Fabian , Evrard Fabien , Castrejón-Pita Alfonso Arturo , Castrejón-Pita José Rafael , van Wachem Berend 
Published: September 2021

AbstractThe evolution of the capillary breakup of a liquid jet under large excitation amplitudes in a parameter regime relevant to inkjet printing is analysed using three-dimensional numerical simulations. The results exhibit a reversal of the breakup length of the jet occurring when the velocity scales associated with the excitation of the jet and surface tension are comparable, and an inversion of the breakup from front-pinching to back-pinching at sufficiently large excitation amplitudes. Both phenomena are shown to be associated with the formation of vortex rings and a local flow obstruction inside the jet, which modify the evolution of the jet by locally reducing or even reversing the growth of the capillary instability. Hence, this study provides a mechanism for the well-known breakup reversal and breakup inversion, which are both prominent phenomena in inkjet printing. An empirical similarity model for the reversal breakup length is proposed, which is shown to be valid throughout the considered range of characteristic parameters. Hence, even though the fluid dynamics observed in capillary jet breakup with large excitation amplitudes are complex, the presented findings allow an accurate prediction of the behaviour of jets in many practically relevant situations, especially continuous inkjet printing.
Gene-by-Crisis Interaction for Optimism and Meaning in Life: The Effects of the COVID-19 Pandemic
Authors: de Vries Lianne P. , van de Weijer Margot P. , Pelt Dirk H. M. , Ligthart Lannie , Willemsen Gonneke , Boomsma Dorret I. , de Geus Eco J. C. , Bartels Meike 
Published: September 2021

AbstractThe corona virus disease 2019 (COVID-19) pandemic and the restrictions to reduce the spread of the virus has had a large impact on daily life. We investigated the individual differences in the effect of the COVID-19 pandemic and first lockdown on optimism and meaning in life in a sample from the Netherlands Twin Register. Participants completed surveys before (N = 9964, Mean age: 48.2, SD = 14.4) and during the first months of the pandemic (i.e. April–May 2020, N = 17,464, Mean age: 44.6 SD = 14.8), with a subsample completing both surveys (N = 6461, Mean age T1: 48.8, SD = 14.5). We applied genetic covariance structure models to twin data to investigate changes in the genetic architecture of the outcome traits due to the pandemic and the interaction of genes with the environmental exposure. Although 56% and 35% of the sample was negatively affected by the pandemic in their optimism and meaning in life, many participants were stable (32% and 43%) or even showed increased optimism and meaning in life (11% and 22%). Subgroups, specifically women, higher educated people, and people with poorer health, experienced larger negative effects. During the first months of the pandemic, slightly lower heritability estimates for optimism and meaning in life (respectively 20% and 25%) were obtained compared to pre-pandemic (respectively 26% and 32%), although confidence intervals overlap. The lower than unity genetic correlations across time (.75 and .63) suggest gene-environment interactions, where the expression of genes that influence optimism and meaning in life differs before and during the pandemic. The COVID-19 pandemic is a strong exposure that leads to imbalanced effects on the well-being of individuals. Some people decrease in well-being, while others get more optimistic and consider their lives as more meaningful during the pandemic. These differences are partly explained by individual differences in genetic sensitivity to extreme environmental change. More knowledge on the person-specific response to specific environmental variables underlying these individual differences is urgently needed to prevent further inequality.
The management effectiveness of protected areas in Kenya
Authors: Onditi Kenneth Otieno , Li Xueyou , Song Wenyu , Li Quan , Musila Simon , Mathenge James , Kioko Esther , Jiang Xuelong 
Published: September 2021

AbstractMerely designating new and/or expanding existing protected areas (PAs) does not guarantee the protection of critical ecosystems and species. The management of PAs must be effective to sustain meaningful conservational outcomes. We inferred the management effectiveness of PAs in Kenya based on the representation of ranges and distribution of multiple diversity dimensions of terrestrial mammals and their association with governance and designation types. We hypothesized that different governance types underlie variable management efficacies, such that stricter-managed PAs have better habitats that attract more wildlife, translating to higher species diversity compared to less strictly-managed PAs, especially for focal species groups (large carnivores, large herbivores, and endangered species). The results showed nearly all terrestrial mammals in Kenya represented in at least one PA. However, the relative proportion of represented ranges were low, and analysis of spatial conservation prioritization showed significant expansion beyond current PAs needed to achieve a one third coverage of focal species’ ranges in a best-solution reserve system. Differences in PA governance and designation types were not systematically associated with diversity variances, and while there were more unique species in state-managed PAs than in privately-managed ones, averaged diversity coefficients were comparable between categories. Diversity variances explained by PA size and status year were low in a combined species pool but increased in focal species groups. These findings suggest that success in terrestrial mammal conservation in PAs in Kenya require clearly and formally streamlined definition, performance feedback, and collaboration terms between state-managed and privately-managed PAs.
Isolation and endemism in subterranean aquatic snails: unexpected case of Montenegrospeum bogici (Pešić et Glöer, 2012) (Gastropoda: Truncatelloidea: Hydrobiidae)
Authors: Falniowski Andrzej , Pešić Vladimir , Lewarne Brian , Grego Jozef , Rysiewska Aleksandra , Osikowski Artur , Hofman Sebastian 
Published: September 2021

AbstractThe subterranean aquatic snails may serve as a model of endemism and isolationvs.migration in subterranean habitats. The aim of the present paper is to verify the hypothesis that subterranean aquatic snails can migrate through diverse subterranean habitats, applying four molecular markers as well as a RAPD technique and shell morphometry. They were used to estimate the differences and gene flow between populations of the hydrobiid subterranean aquatic species Montenegrospeum bogici, collected in the Dinaric karst region. Three molecularly distinct taxonomic units were distinguished. The mOTU B was found at single locality, mOTU C at two, but the mOTU A at ten localities, scattered along 236 km distance, at two of them in sympatry with either mOTU B or C. Within mOTU A, the estimated levels of the gene flow were high. The pairwise measures of genetic differentiation were statistically significantly associated with geographic distances between the populations. In general, neither the infinite-island model of interpopulation differentiation, expected for isolated populations, nor the stepping-stone one, but rather the isolation-by-distance model explained the observed pattern. Our results suggest that interstitial habitats provide ways of migration for the stygobiontM. bogici, as has been already suggested for other subterranean gastropods.
Higher Education Institution–Community Partnerships: Measuring the Performance of Sustainability Science Initiatives
Authors: Plummer Ryan , Witkowski Samantha , Smits Amanda , Dale Gillian 
Published: September 2021

AbstractThe enterprise of sustainability science extends beyond the academy to address pressing environmental issues through collaboration. It coincides with trends in higher education institutions (HEIs) towards an expanded mission for addressing societal challenges as well as greater accountability. In this paper, we aim to establish an instrument for assessing the performance of sustainability science initiatives in HEIs. The performance of three HEI–community partnerships for sustainability science in Ontario, Canada (the Brock-Lincoln Living Lab, the Excellence in Environmental Stewardship Initiative, and Niagara Adapts) were examined using the HEI–Community Partnership Performance Index (HCPPI). Our preliminary results suggest that the HCPPI is a reliable, valid, and easy-to-administer tool for accurately assessing the performance of HEI–community partnerships for sustainability science. Incorporating systemic performance assessments into HEI–community partnerships promotes accountability, transparency, and continuous improvement. It also serves as a vital feedback mechanism by fostering reflection, adaptation, and learning—critical components to sustainability science.
The Application of the Principles of Responsible AI on Social Media Marketing for Digital Health
Authors: Liu Rui , Gupta Suraksha , Patel Parth 
Published: September 2021

AbstractSocial media enables medical professionals and authorities to share, disseminate, monitor, and manage health-related information digitally through online communities such as Twitter and Facebook. Simultaneously, artificial intelligence (AI) powered social media offers digital capabilities for organizations to select, screen, detect and predict problems with possible solutions through digital health data. Both the patients and healthcare professionals have benefited from such improvements. However, arising ethical concerns related to the use of AI raised by stakeholders need scrutiny which could help organizations obtain trust, minimize privacy invasion, and eventually facilitate the responsible success of AI-enabled social media operations. This paper examines the impact of responsible AI on businesses using insights from analysis of 25 in-depth interviews of health care professionals. The exploratory analysis conducted revealed that abiding by the responsible AI principles can allow healthcare businesses to better take advantage of the improved effectiveness of their social media marketing initiatives with their users. The analysis is further used to offer research propositions and conclusions, and the contributions and limitations of the study have been discussed.
The Crystal Structures of Two Hydro-closo-Borates with Divalent Tin in Comparison: Sn(H2O)3[B10H10] · 3 H2O and Sn(H2O)3[B12H12] · 4 H2O
Authors: Kleeberg Fabian M. , Zimmermann Lucas W. , Schleid Thomas 
Published: September 2021

AbstractSingle crystals of Sn(H2O)3[B10H10] · 3 H2O and Sn(H2O)3[B12H12] · 4 H2O are easily accessible by reactions of aqueous solutions of the acids (H3O)2[B10H10] and (H3O)2[B12H12] with an excess of tin metal powder after isothermal evaporation of the clear brines. Both compounds crystallize with similar structures in the triclinic system with space group P$$\bar{1 }$$

1

¯

and Z = 2. The crystallographic main features are electroneutral $${}_{\infty }^{1} \{$$

∞

1

{

Sn(H2O)3/1[B10H10]3/3} and $${}_{\infty }^{1} \{$$

∞

1

{

Sn(H2O)3/1[B12H12]3/3} double chains running along the a-axes. Each Sn2+ cation is coordinated by three water molecules of hydration (d(Sn–O) = 221–225 pm for the B10 and d(Sn–O) = 222–227 pm for the B12 compound) and additionally by hydridic hydrogen atoms of the three nearest boron clusters (d(Sn–H) = 281–322 pm for the B10 and d(Sn–H) = 278–291 pm for the B12 compound), which complete the coordination sphere. Between these tin(II)-bonded water and the three or four interstitial crystal water molecules, classical bridging hydrogen bonds are found, connecting the double chains to each other. Furthermore, there is also non-classical hydrogen bonding between the anionic [BnHn]2− (n = 10 and 12) clusters and the crystal water molecules pursuant to B–Hδ−$$\cdots$$
⋯
δ+H–O interactions often called dihydrogen bonds.
Obstacles and opportunities for reducing dwelling size to shrink the environmental footprint of housing: tenants’ residential preferences and housing choice
Authors: Karlen Claudine , Pagani Anna , Binder Claudia R. 
Published: September 2021

AbstractThe environmental footprint of housing is greatly influenced by the size of a dwelling. Housing size is the result of households’ dwelling selections; accordingly, it is critical to consider residential preferences and choices to inform efforts towards housing sustainability. This study aimed to understand tenants’ preferences for and choices of housing size as one amongst several dwelling characteristics and identify obstacles and opportunities for reducing size in the light of promoting sustainable housing. We employed logistic regression models to analyse a survey with 878 Swiss tenants, and our results identify preference for large dwellings as a major obstacle for reducing dwelling size among affluent tenants. Conversely, tenants with lower income might be forced to move to a smaller dwelling due to financial constraints or attribute higher importance to the financial benefit of lower rents. However, financial disincentives along with substantial non-monetary costs of moving, such as the disruption of local bonds and the difficulty of finding a satisfactory dwelling, can outweigh the benefits of moving to a smaller dwelling. To overcome such obstacles, we suggest offering incentives and other facilitating measures for downsizing moves as well as ensuring an adequate supply of smaller dwellings capable of providing high living quality. We highlight the potential of studying housing functions to conceptualize dwellings fulfilling these requirements.
Relationships Among Belief in God, Well-Being, and Social Capital in the 2020 European and World Values Surveys: Distinguishing Interpersonal and Ideological Prosociality
Authors: Nezlek John B. 
Published: September 2021

AbstractAnalyses of the 2020 combined European and World Values Surveys (124,958 respondents from 77 countries) found that people who believed in God tended to be happier, more satisfied with lives, and healthier than non-believers. Believers trusted people close to them (e.g., neighbors) more than non-believers, although non-believers tended to trust people in general and trust people from other countries more than believers. Non-believers tended to be more ideologically prosocial than non-believers (e.g., belonging to an environmental organization, advocating freedom of speech vs. control). Such differences were stronger in countries in which there were more vs fewer believers. Moreover, these differences remained after controlling for individual differences in sex, age, education, income, and left–right political orientation.
Developmental Trajectories of Science Identity Beliefs: Within-Group Differences among Black, Latinx, Asian, and White Students
Authors: Puente Kayla , Starr Christine R. , Eccles Jacquelynne S. , Simpkins Sandra D. 
Published: September 2021

AbstractThough adolescents’ science identity beliefs predict positive STEM outcomes, researchers have yet to examine developmental differences within racial/ethnic groups despite theoretical arguments for such studies. The current study examined science identity trajectories for Black (14%), Latinx (22%), Asian (4%), and White (52%) students (N = 21,170; 50% girls) from 9thgrade to three years post-high school and the variability within each racial/ethnic group based on gender and college generational status. Contrary to the literature, students’ science identities increased over time, and the increases were larger for potential first- versus continuing-generation White students. Potential continuing-generation boys had stronger 9thgrade science identities than potential first-generation girls in all groups except Asians. The findings suggest who might benefit from additional supports within each racial/ethnic group.
Flexural strength of silica fume, fly ash, and metakaolin of hardened cement paste after exposure to elevated temperatures
Authors: Abdelmelek Nabil , Lubloy Eva 
Published: September 2021

AbstractThe mechanical properties of concrete based mainly on flexural and compressive bearing capacity. Generally, researchers have an interest in the evaluation of compression property through the importance of the flexural performance of the material in the constructions, namely the significance of each mechanical property based upon the position of the structural element. The present experimentally work is directed toward improving the flexural strengths performance of ordinary hardened cement paste (HCP) at ambient and after elevated temperatures exposure. The used parameters were different pozzolanic materials with different replacements ratios to cement mass and different levels of temperature. Results proved the significant contribution of pozzolanic material to enhance the flexural properties of HCP after being exposed to elevated temperatures. The low content of CaO, the high grinding fineness, and the physical morphology of the used pozzolanic materials, made their adoption effective to HCP after exposure to elevated temperatures. Using 3%, 12%, and 15% of silica fume (SF), metakaolin (MK), and fly ash (FA), respectively, showed the highest heat endurance among the other replacements. However, the optimum replacement of MK has shown a better heat endurance than the optimum replacements of SF and FA. On the other hand, the spalling has occurred at high replacements of SF. Finally, the results are supported by means of thermo-gravimetric, SEM, and computed tomography investigations.
A unified framework for closed-form nonparametric regression, classification, preference and mixed problems with Skew Gaussian Processes
Authors: Benavoli Alessio , Azzimonti Dario , Piga Dario 
Published: September 2021

AbstractSkew-Gaussian Processes (SkewGPs) extend the multivariate Unified Skew-Normal distributions over finite dimensional vectors to distribution over functions. SkewGPs are more general and flexible than Gaussian processes, as SkewGPs may also represent asymmetric distributions. In a recent contribution, we showed that SkewGP and probit likelihood are conjugate, which allows us to compute the exact posterior for non-parametric binary classification and preference learning. In this paper, we generalize previous results and we prove that SkewGP is conjugate with both the normal and affine probit likelihood, and more in general, with their product. This allows us to (i) handle classification, preference, numeric and ordinal regression, and mixed problems in a unified framework; (ii) derive closed-form expression for the corresponding posterior distributions. We show empirically that the proposed framework based on SkewGP provides better performance than Gaussian processes in active learning and Bayesian (constrained) optimization. These two tasks are fundamental for design of experiments and in Data Science.