bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volumetric differences in gray and white matter of cerebellar Crus I/IIacross the different clinical stages of schizophrenia
Authors: Morimoto Chie , Uematsu Akiko , Nakatani Hironori , Takano Yosuke , Iwashiro Norichika , Abe Osamu , Yamasue Hidenori , Kasai Kiyoto , Koike Shinsuke 
Published: June 2021

AimSchizophrenia is considered to be a disorder of progressive structural brain abnormalities. Previous studies have indicated that the cerebellar Crus I/II plays a critical role in schizophrenia. We aimed to investigate how specific morphological features in the Crus I/II at different critical stages of the schizophrenia spectrum contribute to the disease.MethodsThe study involved 73 participants on the schizophrenia spectrum (28 with ultra‐high risk for psychosis [UHR], 17 with first‐episode schizophrenia [FES], and 28 with chronic schizophrenia) and 79 healthy controls. We undertook a detailed investigation into differences in Crus I/II volume using a semiautomated segmentation method optimized for the cerebellum. We analyzed the effects of group and sex, as well as their interaction, on Crus I/II volume in gray matter (GM) and white matter (WM).ResultsSignificant group × sex interactions were found in WM volumes of the bilateral Crus I/II; the males with UHR demonstrated significantly larger WM volumes compared with the other male groups, whereas no significant group differences were found in the female groups. Additionally, WM and GM volumes of the Crus I/II had positive associations with symptom severity in the UHR group, whereas, in contrast, GM volumes in the FES group were negatively associated with symptom severity.ConclusionsThe present findings provide evidence that the morphology of Crus I/II is involved in schizophrenia in a sex‐ and disease stage–dependent manner. Additionally, alterations of WM volumes of Crus I/II may have potential as a biological marker of early detection and treatment for individuals with UHR.
Induction of reproductive activity and egg production by gonadotropin‐releasing hormone in non‐laying hens
Authors: Hanafy Ahmed M. , Elnesr Shaaban Saad 
Published: June 2021

AbstractThe current study was conducted to evaluate the effects of gonadotropin‐releasing hormone (GnRH) analogue (Receptal) injection on reproductive traits of fully mature layers hens (32 weeks) suffered from inactive ovaries. Ninety‐six non‐laying hens (TETRA‐SL brown egg layers), selected from a commercial flock, with similar body weight, were randomly assigned to four groups (n = 24). Hens in the 1st group served as a control. Hens of the 2nd, 3rd and 4th groups were individually intramuscularly injected every 4 days with 50, 100 and 150 µl of Receptal solution, respectively, for two times. The results stated that the injection of Receptal induced the non‐laying hens to produce eggs, but control birds did not produce eggs during the experimental period. The distance between pelvic bones and between the pelvic bone and keel bone of hens was significantly improved (p < .001) in groups received different GnRH levels compared with the control group. The best results were observed in the group injected with 100 µl Receptal. Levels of LH, FSH, oestrogen and progesterone hormones were significantly (p < .05) higher in Receptal‐treated groups than in the control group. Hens injected with Receptal had an increase in ovary%, yellow follicles number, oviduct% and oviduct length (p < .001) compared with the control. It was concluded that treating inactive ovaries in non‐laying hens with GnRH injections for two times, 4‐day intervals, is an effective procedure for inducing egg production and useful in cost reduction in layer farms, and the group treated with 100 µl Receptal had the best results.
Computational Fluid Dynamics—Machine Learning Prediction of Machinery Coupling Windage Heating and Power Loss
Authors: Dawahdeh Ahmad , Oh Joseph , Zhai Tianbo , Palazzolo Alan 
Published: June 2021

AbstractCouplings connect the spinning shafts of driving and driven machines in the industry. A coupling guard encloses the coupling to protect personnel from the high-speed rotating coupling. The American Petroleum Institute API publishes standards that restrict the overheating of the coupling guards due to windage caused by the spinning shaft. Based on the most recent version of API 671, the peak temperature for the coupling guard should not exceed 60 °C. This paper proposes a machine learning (ML) model and an empirical formula to predict the maximum guard temperature and power loss. The ML models use a database obtained from simulated computational fluid dynamics (CFD) cases for different coupling guards under various conditions. Also, the paper provides validation for the CFD models with experimental tests for different cases. The proposed ML model uses eight different input parameters to predict temperature and power loss. The model shows an accurate prediction for a varied number of CFD cases. The performance of the generated model has been verified with the experimental results. Also, an empirical formula has been created using the same database from CFD results. The results show that the ML model has better prediction accuracy than the empirical formula for predicting peak temperature and power loss for all cases.
Dynamic Modeling of Spent Fuel Rack Pool Subjected to Seismic Excitation Considering Fluid–Structure Interaction
Authors: Ricciardi Guillaume , Kang Heung Seok , Oh Dong Seok , Lee Kang Hee 
Published: June 2021

Abstract
The spent fuel of a nuclear power plant is generally stored in a wet storage pool. In case of a seismic event, one has to ensure the integrity of the spent fuel and structures holding them called spent fuel racks. In this study, a simple model accounting for 12 racks is proposed and compared with experimental results involving reduced scale racks. Fluid–structure interactions are modeled in terms of added coupling mass and damping, and free surface effects are accounted for. Comparison between simulations and experimental results showed good agreement. In spite of the simplicity of the model, simulations succeed to give a reasonable estimation of racks accelerations and were able to reproduce the effect of excitation amplitude and water level.
A Burst Capacity Model for Corroded Pipelines Subjected to Combined Internal Pressure and Longitudinal Compression
Authors: Zhang Shulong , Zhou Wenxing 
Published: June 2021

Abstract
The present study proposes a new semi-empirical burst capacity model for corroded oil and gas pipelines under combined internal pressure and longitudinal compression. The proposed model evaluates the burst capacity of a corroded pipeline under combined loads as the burst capacity of the pipeline under internal pressure only, which is developed in a recently completed study, multiplied by a correction factor to account for the effect of the longitudinal compression. Extensive parametric elastoplastic finite element analyses (FEA) are carried out, the results of which are used as the basis to develop the correction factor as a function of the corrosion defect sizes and magnitude of the longitudinal compressive stress. The proposed model is validated by a large set of parametric FEA and full-scale burst tests reported in the literature and is shown to provide marked improvements over two existing models, the DNV and RPA-PLLC models, for corroded pipelines under combined loads.
Magnetic resonance/ultrasound fusion targeted biopsy of the prostate can be improved by adding systematic biopsy
Authors: Cauni Victor Mihail , Stanescu Dan , Tanase Florin , Mihai Bogdan , Persu Cristian 
Published: June 2021

Aim: Magnetic resonance/ ultrasound fusion targeted biopsy (Tbs) is widely used for diagnosing prostate cancer (PCa). The aim of our study was to compare the cancer detection rate (CDR) and the clinically significant prostate cancer detection rate (csPCa) of the magnetic resonance/ultrasound fusion targeted biopsy with those of the standard systematic biopsy (Sbs) and of the combination of both techniques.Material and methods: A total of 182 patients underwent magnetic resonance/ultrasound fusion Tbs on the prostate for PCa suspicion based on multiparametric magnetic resonance imaging (mMRI) detection of lesions with PI-RADSv2 score ≥3. A total of 78 patients had prior negative biopsies. Tb was performed by taking 2-4 cores from each suspected lesion, followed by Sb with 12 cores. We evaluated the overall detection rate of PCa and clinically significant prostate cancer, defined as any PCa with Gleason score ≥3+4.Results: Median prostate specific antigen (PSA) level pre-biopsy was 7.4 ng/ml and median free-PSA/PSA ratio was 10.2%. Patient median age was 62 years old. PIRADSv2 score was 3 in 54 cases, 4 in 96 cases and 5 in 32 cases. PI-RADS-dependent detection rate of Tbs for scores 3, 4 and 5 was 25.9%, 65.6% and 84.4%, respectively, with csPCa detection rates of 24.1%, 54.2%, and 71.9%. Overall detection rate was 57.1% for Tbs, which increased to 60.4% by adding Sbs results. Detection rate for clinically significant prostate cancer (csPCa) was 48.4% and increased to 51.1% by adding Sbs. Overall detection rate for repeated biopsy was 50% and 68.3% for biopsy in naïve patients. Sbs detection rate was 55.5%, 8 patients having a negative biopsy on Tbs.Conclusions: When Tbs is considered due to a PI-RADS ≥3 lesion on mMRI, combined Tbs + Sbs increases the overall CDR and csPCa detection rates.
Labyrinth patterns in Magadi (Kenya) cherts: Evidence for early formation from siliceous gels
Authors: Leet Kennie , Lowenstein Tim K. , Renaut Robin W. , Owen R. Bernhart , Cohen Andrew 
Published: June 2021

Abstract
Sedimentary cherts, with well-preserved microfossils, are known from the Archean to the present, yet their origins remain poorly understood. Lake Magadi, Kenya, has been used as a modern analog system for understanding the origins of nonbiogenic chert. We present evidence for synsedimentary formation of Magadi cherts directly from siliceous gels. Petrographic thin-section analysis and field-emission scanning electron microscopy of cherts from cores drilled in Lake Magadi during the Hominin Sites and Paleolakes Drilling Project in 2014 led to the discovery of two-dimensional branching “labyrinth patterns” in chert, which are a type of fractal “squeeze” pattern formed at air-liquid interfaces. Labyrinth patterns preserved in chert from Lake Magadi cores indicate invasion of air along planes in dewatering gels. These patterns support the precipitation of silica gels in the saline-alkaline Lake Magadi system and syndepositional drying of gels in contact with air as part of chert formation. Recognizing cherts as syndepositional has been critical for our use of them for U-Th dating. Identification of labyrinth patterns in ancient cherts can provide a better understanding of paleoenvironmental and geochemical conditions in the past.
Morphological selectivity of the Permian-Triassic ammonoid mass extinction
Authors: Dai Xu , Korn Dieter , Song Haijun 
Published: June 2021

Abstract
Ammonoids suffered a diversity bottleneck during the Permian-Triassic mass extinction (PTME) and experienced a rapid diversification in the Early Triassic. However, the kinds of ammonoids that were more likely to survive the PTME and that fueled subsequent diversification are still poorly known. We compiled a comprehensive morphological data set and used the nonmetric multidimensional scaling method to reveal the impact of the PTME on the morphological selectivity of ammonoids. Our results show that postextinction taxa occupied a quite different morphospace when compared with the pre-extinction assemblages. The survivors were mainly smooth and weakly ornamented forms, while the late Permian species were dominated by coarsely ornamented forms. Contrary to previously recognized nonselective patterns, these results suggest a morphological selectivity of the Permian-Triassic crisis. Newcomers in the Griesbachian were mainly compressed and smooth forms. This morphological shift from the coarsely ornamented ammonoids dominating the Changhsingian to the smooth ammonoids dominating the Griesbachian possibly suggests an ecological turnover of ammonoids during the PTME.
Anisotropy-revealed change in hydration along the Alaska subduction zone
Authors: Lynner Colton 
Published: June 2021

AbstractMegathrust earthquake behavior in subduction zones is controlled by a variety of factors including the hydration state of the subducting slab. Increased hydration reduces the occur-rence of great, damaging earthquakes by diminishing the strength of the material along the interface between tectonic plates. Understanding variations in hydration in subductions zones is necessary for properly assessing the overall hazard posed by each region. Fortunately, seismic anisotropy is strongly dependent upon hydration of the subducting crust and litho-sphere. I present shear-wave splitting measurements that illuminate changes in anisotropy, and therefore hydration, of the subducting Pacific plate beneath the Alaska subduction zone (northern Pacific Ocean). Variations in shear-wave splitting directly correlate to changes in the behavior of great, megathrust earthquakes. My measurements show that the Shumagin seismic gap is characterized by a hydrated subducting slab, explaining the long-term lack of great earthquakes. Observations in the immediately adjacent Semidi segment, which experiences great events regularly, indicate a far less hydrated slab. These results are driven by the preferential alignment of paleo-spreading fabrics of the Pacific plate. Where fabrics are more closely aligned with the orientation of the trench, outer-rise faulting and plate hydration is enhanced. These results highlight the importance of changes in preexisting slab structures and subsequent hydration in the production of great, damaging earthquakes.
Fluorescence Quenching of 3,5-Diphenyl-8-CF3-BODIPY Luminophores Bearing Aminophenyl Substituents by Aromatic Molecules
Authors: Gadomska A. V. , Nevidimov A. V. , Tovstun S. A. , Petrova O. V. , Sobenina L. N. , Trofimov B. A. , Razumov V. F. 
Published: June 2021

Abstract
It has been found that the fluorescence quantum yield of 3,5-diphenyl-8-CF3-BODIPY luminophores with aminophenyl substituents in aromatic solvents strongly depends on the position of the aniline amino group with respect to the position of attachment to the core of the BODIPY molecule. It has been suggested and substantiated that the reason for quenching of BODIPY meta-isomers is the specific interaction of luminophore molecules with aromatic molecules.
Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury
Authors: Tettero Jesse Marc , van Eeghen Elmer , Kooter Albertus Jozef 
Published: June 2021

Hypercalcaemia due to immobilisation is an uncommon diagnosis and requires extensive evaluation to rule out common causes of hypercalcaemia such as primary hyperparathyroidism and malignancy.We report an unusual case of profound hypercalcaemia due to immobilisation in a young man due to acute spinal cord ischaemia, leading to paraplegia. Other causes of hypercalcaemia were ruled out and elevated bone turnover markers supported our hypothesis. Conventional treatment with intravenous fluids, bisphosphonates and diuretics was insufficient. Subcutaneous calcitonin lowered the plasma calcium acutely and was continued for 8 weeks. Subsequent normocalcaemia was sustained for 2 years.
Peer-led HIV care and the UNAIDS 90-90-90 treatment targets in Tigrai, Ethiopia: a cluster randomised trial and economic evaluation ofteach-test-link-tracemodel (TTLT) trial protocol
Authors: Gesesew Hailay , Ward Paul , Karnon Jonathan , Woodman Richard , Mwanri Lillian 
Published: June 2021

IntroductionThis study will evaluate the acceptability and effectiveness of a new intervention programme calledteach-test-link-trace(TTLT) model in Tigrai, Ethiopia, where peer educators counsel about HIV (teach), perform house-to-house HIV testing (test) through pinprick HIV testing (H2H) or OraQuick HIV self-testing (HIVST), link HIV-positive patients to HIV care (link) and trace lost patients house-to-house (trace).Methods and analysisThe four-arm cluster randomised trial will be conducted in five phases:Phase 1will assess the acceptability of the TTLT model using a cross-sectional survey among adults aged 18 years irrespective of HIV status in 6909 households from 40 villages (kebeles).Phase 2will assess effectiveness of the TTLT model through comparing intervention and control groups among HIV negative or unknown HIV status. The intervention groups will receive one of the three home-based interventions provided by peer educators: (1) demonstrate and distribute OraQuick HIV self-testing kits (HIVST), (2) perform pinprick HIV testing (H2H) and (3) offer a choice to either receive HIVST or H2H. The control group will receive the standard care in which nurses counsel and refer eligible household members to nearby health facilities to access existing HIV testing services. The primary outcomes of the interventions are proportion of individuals who know of their HIV status (first 90), link to HIV care and treatment (second 90) and meet virological suppression (third 90). We will perform process evaluation through qualitative interviews inphase 3, economic evaluation for cost-effectiveness analysis inphase 4and a sustainability exit strategy using nominal group technique inphase 5. We will apply descriptive and inferential statistics for quantitative studies, and thematic framework analysis for qualitative studies.Ethics and disseminationEthics approval was obtained from the Southern Adelaide Clinical Health Research Ethics Committee (SAC HREC), South Australia, and findings will be disseminated through publications, conference presentations, media release and policy briefs.Trial registration numberACTRN12620000570987p.
Soft-shell headgear, concussion and injury prevention in youth team collision sports: a systematic review
Authors: Makovec Knight Jennifer , Nguyen Jack V. K. , Mitra Biswadev , Willmott Catherine 
Published: June 2021

ObjectivesTo assess the association between soft-shell headgear (HG) use and sports-related concussion (SRC). Secondary objectives were to assess the association between HG and superficial head injury and investigate potential increase in injury risk among HG users.DesignA systematic search in Ovid MEDLINE, Cochrane Library, Scopus, PsycINFO and SPORTDiscus was conducted in April 2020. Inclusion criteria were youth <18, English language, in vivo studies published after 1980 that evaluated SRC and other injury incidence in HG users compared with non-users.Outcome measuresIncidence rates of SRC, superficial head injury or other injuries.ResultsEight studies were eligible. The majority (n=5) reported no difference in the rate of SRC among HG users versus non-users. One rugby study identified significantly lower risk of SRC for non-HG users (risk ratio (RR) 0.63; 95% CI 0.41 to 0.98) compared with HG users, whereas a cross-sectional survey of soccer players indicated higher risk of SRC for non-HG users (RR 2.65; 95% CI 1.23 to 3.12) compared with HG users. Three of the four studies investigating superficial head injury found no significant differences with HG use, though the soccer survey reported reduced risk among HG users (RR 1.86; 95% CI 0.09 to 0.11). Increased incidence of injuries to all body regions for rugby HG users was reported in two studies with adjusted RRs of 1.16 (95% CI 1.04 to 1.29) and 1.23 (95% CI 1.00 to 1.50).ConclusionsHG use was not associated with reduced rates of SRC or superficial head injury in youth soccer and rugby. The possibility of increased injury risk to all body regions for rugby HG users was raised. The need for research specific to youth and female athletes was highlighted.PROSPERO registration numberCRD42018115310.
Community social support and onset of dementia in older Japanese individuals: a multilevel analysis using the JAGES cohort data
Authors: Miyaguni Yasuhiro , Tabuchi Takahiro , Aida Jun , Saito Masashige , Tsuji Taishi , Sasaki Yuri , Kondo Katsunori 
Published: June 2021

ObjectiveRecently, there has been an increase in the number of people with dementia. However, no study has examined the association between community-level social support and the onset of incident dementia using multilevel survival analysis.DesignA prospective cohort study.Participants and settingWe analysed data pertaining to 15 313 (7381 men and 7932 women) community-dwelling adults aged 65 years or older who had not accessed long-term care insurance and were living in Aichi Prefecture (seven municipalities) in Japan.Primary and secondary outcome measuresThe association between community-level social support and onset of incident dementia was examined using the Japan Gerontological Evaluation Study, a prospective cohort study introduced in Japan in 2003. Incident dementia was assessed using Long-term Care Insurance records spanning 3436 days from the baseline survey.ResultsDuring the 10-year follow-up, the onset of incident dementia occurred in 1776 adults. Among older people, a 1% increase in community-level social support (in the form of receiving emotional support) was associated with an approximately 4% reduction in the risk of developing dementia, regardless of socio-demographic variables and health conditions (HR=0.96; 95% CI=0.94 to 0.99).ConclusionsReceiving community-level social support in the form of emotional support is associated with a lower risk of developing incident dementia.
Trends of injury mortality during the COVID-19 period in Guangdong, China: a population-based retrospective analysis
Authors: Zheng Xue-Yan , Tang Si-Li , Ma Shu-Li , Guan Wei-Jie , Xu Xiaojun , Xu Haofeng , Xu Ying-Shan , Xu Yan-Jun , Lin Li-Feng 
Published: June 2021

ObjectiveWe aimed to ascertain the trends of injury mortality during the COVID-19 period in southern China.MethodsWe conducted a population-based retrospective analysis to compare the mortality changes of all-cause injury and transport injuries, poisoning, falls, fire/heat/hot substances, drowning, self-harm and interpersonal violence, which were further stratified by sex and age. Comparisons were made between the COVID-19 period (between January 2020 and June 2020) and control period (between January 2019 and June 2019) in Guangdong province. We used the negative binomial models to explore the associations of deaths during the COVID-19 period, according to the different sex and age strata.ResultsThe all-cause injury mortality in Guangdong province decreased significantly from 28.65 per 100 000 population during the control period to 23.24 per 100 000 population during COVID-19 pandemic period. Similar results were found in specific injury categories. Mortality of self-harm increased by 139.26% in the 10–14 year group during the COVID-19 period as compared with the control period. Although mortality changes in some groups were not statistically significant, some increases were noteworthy during the COVID-19 period (ie, self-harm, transport injury and falls) in the 70–79 year group. The corresponding increase in mortality rate was 16.83%, 3.32% and 4.92%, respectively.ConclusionThe mortality of all-cause injury, transport injury and drowning during the COVID-19 pandemic was consistently decreased. However, the increase in mortality associated with falls, fire/heat/hot substance injury and self-harm in specific age populations warrant the targeted control and prevention measures for the population at risk.