bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary gastrointestinal stromal tumor of the left hepatic lobe: a case report and a review of the literature
Authors: Piachas Athanasios , Tooulias Andreas , Tsoulfas Georgios 
Published: November 2021

Abstract
Gastrointestinal stromal tumors (GISTs) can arise from any site of the gastrointestinal tract. These tumors are known to originate from the interstitial cells of Cajal, located in the gastrointestinal mesenchyme. In the case presented, a 37-year-old Caucasian male was admitted to our Surgery department with 2-month history of mild abdominal pain, early satiety and flatulence. The computed tomography revealed a huge mass in the left hepatic lobe consisting of both spindle and epithelial cells. Immunohistochemistry revealed strong CD117 positivity expression. Only a few other cases of liver GIST have been reported in the literature.
Three dimensional Doppler tomography
Authors: Marsh T R 
Published: November 2021

ABSTRACT
Doppler tomography is a method to compute the emissivity distribution within the co-rotating frames of binary stars from observations of their emission line profiles at multiple orbital phases. A key assumption of the method as it is usually applied is that all gas flow is parallel to the orbital plane of the binary. In this paper, I examine the possibility of lifting this assumption to allow for motion parallel to the orbital ‘z’ axis of the binary as well. I show that the problem is best considered in Fourier space, and that line profiles directly constrain the 3D Fourier transform of the 3D Doppler image in velocity space, but only over the 2D surface of a double-cone centred upon the origin, and aligned with the axis reciprocal to the vz velocity axis. Hence the full information needed for the recovery of the 3D emissivity distribution is simply not available. Despite this, an inversion method is presented and tested on a number of simulated images. While artefacts resulting from the missing information do appear, the tests suggest that there could be some value in applying 3D Doppler tomography to data from real systems, although considerable care is needed when doing so.
Spatial differences in stoichiometry of EGR phosphatase and Microtubule-associated Stress Protein 1 control root meristem activity during drought stress
Authors: Longkumer Toshisangba , Chen Chih-Yun , Biancucci Marco , Bhaskara Govinal Badiger , Verslues Paul E 
Published: November 2021

Abstract
During moderate severity drought and low water potential (ψw) stress, poorly understood signaling mechanisms restrict both meristem cell division and subsequent cell expansion. We found that the Arabidopsis thaliana Clade E Growth-Regulating 2 (EGR2) protein phosphatase and Microtubule-Associated Stress Protein 1 (MASP1) differed in their stoichiometry of protein accumulation across the root meristem and had opposing effects on root meristem activity at low ψw. Ectopic MASP1 or EGR expression increased or decreased, respectively, root meristem size and root elongation during low ψw stress. This, along with the ability of phosphomimic MASP1 to overcome the EGR-mediated suppression of root meristem size and the observation that ectopic EGR expression had no effect on unstressed plants, indicated that during low ψw EGR activation and attenuation of MASP1 phosphorylation in their overlapping zone of expression determines root meristem size and activity. Ectopic EGR expression also decreased root cell size at low ψw. Conversely, both the egr1-1 egr2-1 and egr1-1 egr2-1 masp1-1 mutants had similarly increased root cell size but only egr1-1egr2-1 had increased cell division. These observations demonstrated that EGRs affect meristem activity via MASP1 but affect cell expansion via other mechanisms. Interestingly, EGR2 was highly expressed in the root cortex, a cell type important for growth regulation and environmental response.
Gödel-type solutions in Einstein–Maxwell–scalar field theories
Authors: Ishihara Hideki , Matsuno Satsuki 
Published: November 2021

Abstract
We show that the one-parameter family of Gödel-type metrics are exact solutions in a wide class of Einstein–Maxwell–scalar field theories. In these solutions, the gauge field has a one-form expectation value parallel to the timelike contact form that represents the rotation of the Gödel universe.
TISSUE-EQUIVALENCE OF H2 GAS FOR MICRODOSIMETRY IN NEUTRON FIELDS: A GEANT4 MONTE CARLO STUDY
Authors: Chattaraj Arghya , Selvam T Palani 
Published: November 2021

Abstract
Hydrogen (H2) as filling gas in Tissue-equivalent proportional counter (TEPC) for measurements of microdosimetric distributions in neutron fields is investigated using the Monte Carlo-based Geant4 toolkit. The neutron fields considered are monoenergetic neutrons (1 keV–14 MeV) and ISO reference neutron sources 241Am-Be, 241Am-B, 252Cf and 252Cf + D2O. Based on the energy deposited in the gas cavities (tissue-equivalent (TE) propane and H2) of the TEPC, density scaling correction, ${f}_{\rho }$, to be applied on H2 gas to achieve tissue-equivalence is calculated for the above sources at 1μm site size. The calculated value of ${f}_{\rho }$ for the ISO-neutron sources is 0.40, which suggests that energy deposition in the gas cavities is predominantly due to crossers. In the case of monoenergetic neutrons, depending upon the energy, ${f}_{\rho }$ is in the range of 0.11–0.45. The study shows that the TE propane and H2-based microdosimetric distributions are comparable when the density of H2 is scaled appropriately. Mean quality factor $\overline{Q}$ calculated based on microdosimetric distribution increases initially with neutron energy up to 100 keV and thereafter decreases with energy. Depending upon the neutron energy, TE propane and H2-based $\overline{Q}$ values are comparable to within 3–15%, and for the ISO sources, the comparison is within 5–8%. For the ISO neutron sources, $\overline{Q}$ values are in the range of ~10–15.
Enabling disruptive innovations: a comparative case study of Uber in New York City, Chicago and San Francisco
Authors: Occhiuto Nicholas 
Published: November 2021

Abstract
Much research on disruptive innovations has focused on firms that disrupt existing industries. Yet, regulators and lawmakers are instrumental in containing or enabling market disruption, in ways that are less understood. This article examines taxi industries in New York City, Chicago and San Francisco between 2010 and 2014 to better understand the role of regulators and lawmakers in enabling Uber to disrupt these industries. Relying on 142 interviews, ethnographic observations and primary source documents, I show that regulators and lawmakers used two strategies in responding to Uber: blocking and incorporating. Blocking refers to measures that stop a firm from entering the industry. Incorporating refers to adding, subtracting or modifying regulations to align with an innovative firm’s practices. I identify three incorporating strategies: horizontal venue shifting, vertical venue shifting and reinterpreting existing regulations. Analyzing these strategies more clearly illuminates regulatory change mechanisms and lawmakers’ and regulators’ role in enabling disruptive innovations.
Work Primacy and the Social Incorporation of Unaccompanied, Undocumented Latinx Youth in the United States
Authors: Canizales Stephanie L 
Published: November 2021

Abstract
This study investigates the social incorporation of unaccompanied, undocumented Latinx youth workers as they come of age in the United States. Based on research with undocumented Central American and Mexican young adults who grew up as unaccompanied minors in Los Angeles, California, the data reveal that the pressures of financial obligations to families in the sending country and their own sobrevivencia (survival) in the United States, along with limited financial and social resource and mobility, produce a social incorporation trajectory shaped by the primacy of work. Work primacy conditions youth’s educational opportunities, community embeddedness, and family relationships and limits unaccompanied, undocumented youth’s ability to establish and maintain social networks with consequences for their social incorporation. The precarious occupations within the secondary labor market that are characterized by long hours, low wages, labor market restrictions, and unsafe and unsanitary work conditions limit opportunities for socioeconomic mobility for all youth. Women and Indigenous youth are distinctly affected by work primacy. This research advances our understanding of immigrant youth’s lives by examining how institutional context, familial obligations across borders, and limited ethnic networks play a role in shaping the incorporation experiences of unaccompanied, undocumented Latinx immigrants as they come of age in the United States.
Simple Hematological Markers in Predicting the Severity of Transient Tachypnea of Newborn: New Wine in Old Bottles
Authors: Bolat Fatih , Haspolat Necla Yuce , Bolat Guher , Şahin Murat 
Published: November 2021

Abstract

Objectives
To evaluate the validity of red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet mass index (PMI) of patients with transient tachypnea of the newborn (TTN), and to find out their roles in predicting severity of TTN.

Patients and Methods
In this prospective study, hematological parameters (RDW, PMI) and ratios (NLR, PLR) of 147 patients with TTN and 147 full-term healthy controls were evaluated and compared at birth and at 72nd h of life.

patient
s with TTN and 147 full-term healthy controls were evaluated and compared at birth and at 72nd hours of life.

Results
RDW and NLR were not only significantly higher in patients with TTN at birth (p = 0.001) and at 72nd hours of life (p: 0.001), but also were correlated with days of nasal continuous positive airway pressure therapy, duration of O2 therapy, TTN clinical scores, hospitalization and TTN duration. At a cut-off value of 2.40, NLR had a sensitivity of 82.5% and specificity of 77.5% to predict TTN, the most striking parameter at 72nd hours of life. RDW of 17.75 was also determined as the predictive cutoff value of TTN (sensitivity 72.5%; specificity 67.5%; area under the receiver–operating characteristic curve 0.80; p = 0.001). Multivariate analysis model adjusted for delivery, gestational age, male gender revealed that RDW and NLR were significantly and independently associated with TTN.

Conclusion
RDW and NLR both at birth and at 72nd hours of life can be used as biomarkers to distinguish TTN patients from healthy newborns and to predict the severity of TTN.
The Role of Income Inequality for Poverty Reduction
Authors: Bergstrom Katy 
Published: November 2021

AbstractThis paper approximates the identity that links growth in mean incomes and changes in the distribution of relative incomes to reductions in absolute poverty and examines the role of income inequality for poverty reduction. Under the assumption that income is log-normally distributed, we show that we can approximate this identity well. We find that the inequality elasticity of poverty reduction is larger, on average, compared to the growth elasticity of poverty reduction and that the growth elasticity declines steeply with a country’s initial level of inequality. However, we find that prior changes in poverty were, in large part, explained by changes in mean incomes. This is a consequence of changes in income inequality being an order of magnitude smaller than changes in mean incomes. Overall, our results highlight the important role income inequality can play in reducing poverty despite prior poverty changes being, in large part, a consequence of economic growth.
Development of Dolutegravir Single-entity and Fixed-dose Combination Formulations for Children
Authors: Singh Rajendra P. , Adkison Kimberly K. , Baker Mark , Parasrampuria Ridhi , Wolstenholme Allen , Davies Mark , Sewell Nicola , Brothers Cindy , Buchanan Ann M. 
Published: November 2021

Background:
The World Health Organization (WHO) 2019 antiretroviral treatment guidelines recommend use of optimal treatment regimens in all populations. Dolutegravir-based regimens are the preferred first-line and second-line treatment in infants and children with HIV 4 weeks of age and above. There is an urgent need for optimal pediatric formulations of dolutegravir as single-entity (SE) and fixed-dose combination (FDC) to ensure correct dosing and adherence for swallowing and palatability. This article outlines the chronology of dolutegravir pediatric formulation development as granules and conventional and dispersible tablets in a total of 5 pharmacokinetic studies evaluating the relative bioavailability of dolutegravir SE and FDC formulations in healthy adults.

Methods:
The relative bioavailability studies were 2-part, Phase I, open-label, randomized studies in healthy adults. Dolutegravir SE study compared conventional dolutegravir 50 and 25 mg with equivalent conventional 10-mg and dispersible 5-mg tablets, respectively. Subsequently, dolutegravir FDC study compared adult FDC of abacavir/dolutegravir/lamivudine and adult FDC of dolutegravir/lamivudine with their respective pediatric FDC formulations, taken as dispersion immediately or swallowed whole.

Results:
As observed in previous studies, dolutegravir administered as dispersion (granules/dispersible tablets) showed relatively higher bioavailability compared with conventional tablets. The bioavailability of dolutegravir dispersible tablets (both SE and FDC) was approximately 1.6-fold higher when compared with conventional tablets. In addition, the bioavailability of abacavir/lamivudine was not impacted by dispersible formulation.

Conclusions:
These studies demonstrate the successful development of pediatric dolutegravir-containing formulations as SE and FDC that permit pediatric dosing in line with WHO recommendations.
Molds and More: Rare Fungal Infections in Preterm Infants <24 Weeks of Gestation
Authors: Mehler Katrin , Cornely Oliver , Seifert Harald , Zweigner Janine , Janssen Saskia , Oberthuer André 
Published: November 2021

Background:
Extreme immature infants are at an increased risk of fungal infection due to immaturity of the skin barrier and the immune system. Besides Candida infections, in particular, Aspergillus may cause life-threatening diseases in preterm infants. Frequently, Aspergillus primarily affects the skin and may cause extensive damage.

Methods:
We searched our hospital database for fungal infections other than Candida in preterm infants treated between 2015 and 2020 at our level III neonatal intensive care unit of the University Hospital of Cologne.

Results:
In total, 13 preterm infants were identified. Of these, 11 had cutaneous Aspergillosis, one infant had severe enterocolitis caused by Aspergillus and Rhizopus and one had invasive intraabdominal Trichosporon mucoides infection. All infants were born <24 weeks of gestation, were delivered due to premature labor or chorioamnionitis, and had received prenatal steroids and/or hydrocortisone. Voriconazole and liposomal Amphotericin B were first-line treatments and the length of treatment varied between 3 and 148 days. Two infants died associated with severe infection. Liver toxicity was observed in six infants treated with Voriconazole. Therapeutic drug management for Voriconazole was performed in four infants. Target levels were not achieved by the doses that are recommended.

Conclusions:
Rare fungal infections, predominantly cutaneous Aspergillosis affects the most immature preterm infants and may cause severe disease. Treatment with Voriconazole has a high rate of liver toxicity and target levels are difficult to achieve in extremely immature infants.
Components of Stress and Their Associations With Sleep Problems
Authors: Virtanen Marianna , Myllyntausta Saana , Karkkola Petri , Pentti Jaana , Ropponen Annina , Vahtera Jussi , Stenholm Sari 
Published: November 2021

Objective:To identify latent components from among 13 work and nonwork stressors and to examine whether the accumulation of stress factors within these components was associated with sleep problems.Methods:A cohort of older employees(n= 2771 individuals,n= 3921 person-observations) responded to at least two surveys. Principal Component Analysis (PCA) was used to identify latent components. Analysis of variance was used to examine their associations with sleep.Results:The components were: “Physical workload and shift work,” “Psychosocial workload,” “Social and environmental nonwork adversity,” and “Life event- and health-related nonwork adversity.” They were consistently associated with sleep problems, except for “Physical workload and shift work.” “Social and environmental nonwork adversity” was associated with sleep problems at follow-up.Conclusions:Clusters of work- and nonwork-related stressors were identified, and their accumulation was associated with sleep problems among older employees.
Cost of Lost Productivity Due to Erectile Dysfunction and Impact of Employer Benefit Exclusion of Penile Prosthesis Implantation Treatment
Authors: Rojanasarot Sirikan , Bhattacharyya Samir K. , Burnett Arthur L. 
Published: November 2021

Objective:
We examined the cost of lost productivity due to erectile dysfunction (ED) and employer benefit exclusion of penile prosthesis implantation (PPI) among men with employer-sponsored health insurance.

Methods:
A decision-analytic model was developed using administrative claims data, US Bureau of Labor Statistics, and published literature. The economic impact of ED productivity loss and PPi benefit exclusion was reported in2019USD.

Results:
Men with ED had an additional 282.7 hours/ year of work impairment compared to men without ED, resulting in annual incremental costs of $7270. US employers excluding PPi benefits could lose $9.3billion/year of work due to additional work impairment from ED.

Conclusions:
Productivity loss due to ED and PPI benefit exclusion have considerable economic impacts on men with ED and their employers. continuous advocacy for benefit exclusion removal is needed to ensure appropriate patient access.
Sirolimus Leads to Rapid Improvement in Fibroadipose Vascular Anomalies
Authors: Al-Huniti Ahmad , Fantauzzi Michelle , Willis Laura , Sadlier Muriel , Amaral Joao G. , Carcao Manuel D. 
Published: November 2021

Purpose:
Fibroadipose vascular anomaly (FAVA) is a complex vascular anomaly associated with postzygotic somatic PIK3CA mutations. FAVAs can cause significant pain, swelling, and musculoskeletal dysfunction. Treatment options are limited. Sirolimus is a well-tolerated and effective treatment for patients with FAVA. We report our experience of using sirolimus to treat 11 children with FAVAs.

Methods:
We conducted a retrospective review of all patients with FAVA treated with sirolimus in our institution.

Results:
Fourteen patients (10 females) were referred for sirolimus therapy for FAVA. Eleven patients were initiated on sirolimus at a mean age of 14 years (range: 9–17.9 years) and were then treated for a mean of 19 months (range: 1–46 months). Five had previously undergone sclerotherapy without benefit. Sirolimus was initiated at a dose of either 2.5 mg/m2 once daily or 0.8 mg/m2 twice daily. Doses were titrated to maintain sirolimus trough levels of 5–15 ng/L. Goals of treatment were improvement in pain and musculoskeletal dysfunction. All 11 patients reported reduced pain; 7 reporting this within 3 weeks of starting sirolimus. This allowed for discontinuation of analgesia. Function improved significantly in 9 of 11, leading to resumption of sports or work participation. Sirolimus side effects were similar to prior reports, most commonly mouth sores, mildly elevated lipids and acne. There was no grade III/IV toxicity.

Conclusion:
Sirolimus is a well-tolerated and effective treatment for patients with FAVA. Initial symptom improvement is rapid, with significantly reduced pain and improved function. We believe that sirolimus should be considered for all patients with FAVA as a first-line therapy before surgical/interventional approaches.
The Effects of a Pass-Fail Curriculum on a Physician Assistant Program
Authors: Garbas Breann , Fromm Jason 
Published: November 2021

Purpose
The grading scale for students in a physician assistant program of study is not standardized. Students may be evaluated on a traditional 5-tiered A to F scale or a pass-fail system. The decision to change from ordered grading to pass-fail at an established program in the southeast was done following a change in the affiliated School of Medicine. The purpose of this study was to review effects on student scores following such a change.

Methods
The Physician Assistant National Certifying Exam (PANCE) and PACKRAT 2 exam scores for the last 2 cohorts of students scored in the 5-tiered system (2016, N = 60 and 2017, N = 59) were compared against the same for the first 2 cohorts (2018, N = 59 and 2019, N = 58) of the pass-fail system. Nonrandom sampling of all students in each cohort year was evaluated using 2-tailed t-testing.

Results
A total of 236 student scores were evaluated using a 95% confidence interval. The traditionally scored classes outperformed all pass-fail cohorts (means 460.67/491.86 versus 503.34/493.92). P values were found to be significant at all values between the 5-tier scored classes and the pass-fail cohorts in PANCE scoring, resulting in failure to reject the null hypothesis. This was also true for the PACKRAT 2 with the exception of the 2019 cohort, which was significant only for outperformance of the other pass-fail cohort. For the purpose of this study, the only analysis performed was scoring.

Conclusion
For cohorts undergoing curricular change, unforeseen impacts on initial standardized exam scores may occur. In this study, PANCE scores for the first year of the 2 pass-fail cohorts decreased while the overall program scores remained at or above the national average. The pass-fail cohort did show an upward trend in the second year of the curriculum, suggesting that as programs become more familiar with the pass-fail system, steady improvements occur. This suggests that while an anticipated drop in initial scores may be expected, further studies are needed to evaluate the impact on stress reduction, long retention, and intraclass competition.