bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is It Time to Consider the Androgen Receptor as a Therapeutic Target in Breast
Cancer?
Authors: Forooshani Melika Kooshki , Scarpitta Rosa , Fanelli Giuseppe Nicolò , Miccoli Mario , Naccarato Antonio Giuseppe , Scatena Cristian 
Published: December 2021

:
Breast cancer (BC) is a heterogeneous disease and the most prevalent malignant tumor in women worldwide.
The majority of BC cases are positive for estrogen receptor (ER) and progesterone receptor (PgR), both known
to be involved in cancer pathogenesis, progression, and invasion. In line with this, hormonal deprivation therapy appears
to be a useful tool and an effective treatment for these BC subtypes. Unfortunately, prognosis among patients
with hormone-negative tumors or therapy-refractory and metastatic patients remains poor. Novel biomarkers are urgently
needed in order to predict the course of the disease, make better therapy decisions and improve the overall survival
of patients. In this respect, the androgen receptor (AR), a member of the hormonal nuclear receptor superfamily
and ER and PgR, emerges as an interesting feature widely expressed in human BCs. Despite the advances, the precise
tumorigenic mechanism of AR and the role of its endogenous ligands are yet not well-understood. In this review, we
aim to elaborate on the prognostic impact of AR expression and current AR-targeting approaches based on previous
studies investigating AR's role in different BC subtypes.
Using Mobile Phone Apps to Deliver Rural General Practitioner Services: Critical Review Using the Walkthrough Method
Authors: O'Sullivan Belinda , Couch Danielle , Naik Ishani 
Published: December 2021

Background
The widespread use of mobile phones represents new frontiers for improving access to health care. This includes using mobile apps to deliver general practitioner (GP) services in rural areas. However, the wider adoption of apps for increasing access to rural GP services relies on understanding how they might intersect with the rural health system context.

Objective
This research aims to critically review mobile apps for delivering GP services in a rural health service context using the walkthrough method.

Methods
The sample comprised 3 GP service apps under the top 100 list in the medical category in the Apple App Store (also available via the Google Play Store) in Australia as of June 2020. The walkthrough method was applied to extract data and critique the explicit factors, such as the app interface elements, and implicit factors, such as the embedded cultural features related to use for people in rural settings. Data analysis was undertaken between 3 researchers over 6 months applying the walkthrough method and using critical reflection.

Results
There were 3 main themes: improving rural access, addressing rural health care needs, and providing quality of care. App-based GP services may improve rural GP service availability. However, this may be at a relatively superficial level that does not encompass the scope and intensity of the services needed in rural areas (including relevant chronic and emergency care) at a cost that rural patients can afford. The apps showed signs of limited tailoring to the cultural dimensions of rural health care as a barrier to rural use. Patients generally self-selected to use GP service apps with limited support, potentially leading to inappropriate uptake especially by disadvantaged groups with lower health literacy. Although the apps claimed to avail most GP services (70%-80% in some cases), it emerged after enrollment that emergency, complex, and serious conditions might be excluded, potentially imposing more complex caseloads on in-person rural GPs. Apps provided limited information about continuity and coordination of care and sharing information with rural GPs, potentially leading to fragmented and low-quality care. There was commonly no assurance of rural skills and experience of physicians staffing apps despite the wider scope of skills needed to be effective in rural general practice.

Conclusions
GP apps may increase the availability of GP services, but they may require clearer exclusions, appropriate use through decision-making tools, more rural-tailored interfaces, and capacity to align appointment times and costs with patients with complex needs to engage and be useful in a rural context. It is also important to consider how these app-based services could share information with local health care staff for safety and continuity of rural primary care. Finally, information about the physicians’ rural training and experience is critical for quality.
In memoriam Roberts Freimuts (1951–2020)
Authors: Liepiņa Anita , Liepiņš Guntis 
Published: December 2021

Toronto Zinātņu centrā 1974. gadā ir beigusies filmas Nāves ēnā izrāde. Pirmā filma no Latvijas. Izpārdota! Finansiāli privāti riskēta un izkārtota. Ārā ejot, Guntim un Anitai Liepiņiem piesteidzas jauns cilvēks, pateicas par izrādi un piesolās labprāt palīdzēt kārtot nākamos sarīkojumus.Tā sākās draudzība un sadarbība 40 gadus, kopēja darbība Dardedzē un Ave Sol Kanādā valdēs, uzturot sakarus ar Latviju. Par to viņš 2003. gadā saņēma Triju Zvaigžņu ordeņa Zelta goda zīmi. Dzimis Kanādā 1951. gada 30. jūnijā, Roberts apmeklēja Toronto Latviešu biedrības skolu un latviešu ģimnāziju, piedalījās arī skautu kustībā. Bērnībā vasaras pavadīja gan Sidrabenes vasaras nometnē, gan ģimenes vasarnīcā.Latviju Roberts pirmo reizi apciemoja 1977. gadā. Pēc tam gandrīz katru otro gadu. Par sakariem ar Latviju Robertu izmeta no korporācijas Talavija. Bet viņš Talaviju vai kādu no talaviešiem ar ļaunu nepieminēja. Vēlāk viņš pievienojās Austrumam. Ilgus gadus bija atbildīgs par e-pasta saziņu. Kanādas kopas vecākais divas reizes, vecākā vietnieks vienu reizi, sekretārs četras reizes un vēstkopas redaktors divas reizes. Izpalīdzīgs ar savām zināšanām latviešu sabiedrībā, viņš gadiem izkārtoja savienojumu Latvijas Valsts prezidenta uzrunai Latviešu centrā 18. novembrī, Latviešu centra dienā Latvijai.Robertam bija plašas intereses. Pilota licence no agriem 70. gadiem līdz vēliem 80. gadiem. Viņam patika fotografēt, abi ar Marutu dejoja tautas dejas ar Diždanci, Hamiltonas Vainadziņu un Dižo danci, viņi apmeklēja gan beisbola spēles, gan operu. Viņš bija ieguvis lietišķo zinātņu bakalaura grādu fotogrāfijā (Bachelor of Applied Arts – Photographic Arts) akadēmisko grādu Raiersona Politehniskajā institūtā (Ryerson Polytechnic Institute), tagad Raiersona Universitāte (Ryerson University) Toronto, kur viņš turpināja strādāt vizuālo mākslu (Image Arts) nodaļā 35 gadus, aizejot pensijā 2010. gadā. Divdesmit gadus Robertu mocīja Parkinsona slimība. Liktenis bija lēmis, ka viņš zaudēja samaņu, ciemojoties Latvijā 2015. gadā, un tika pārvests atpakaļ uz Kanādu. Viņš kļuva par gultas pacientu ar ļoti ierobežotām spējām sazināties. Robertu apciemojot, bija jāvalkā speciāls tērps, lai viņu pasargātu no slimībām. Bet mūžībā viņu aizsauca 2020. gada 21. novembrī.Ar savu sieviņu Marutu Roberts iepazinās 1976. gada dziesmu svētkos Toronto un apprecējās 1985. gadā, mijot gredzenus pēc dievturības tradīcijas, kājas uz akmens turēdami. No mātes puses viņā ritēja lībiešu asinis. 2013. gadā Freimutu ģimenes svētku sveiciens bija arī lībiešu valodā: Rīemliži Taļšpivḑi ja pǟgiņ vonnõ ūdõs āigastõs! (Priecīgus Ziemassvētkus un daudz laimes nākamā gadā!).Robertam vissvarīgākais dzīvē bija viņa ģimene, Maruta, meitas – Audra un Tija – un viņa tauta.
Culture transformation in Targowisko microregion. Trends of changes inside Danubian farmers
Authors: Kadrow Sławomir , Posselt Martin , Saile Thomas , Wąs Marcin , Abramów Joanna , Golański Adam 
Published: December 2021

The aim of this article is to deepen the discussion on the nature and mechanisms of culture change based on the analysis of newly acquired materials from the Targowisko settlement region. Three groups of materials were acquired (from narrow time horizons) related to the single-phase relics of Linienbandkeramik (Brzezie, site 40 and Targowisko, site 16) and Malice culture houses (Targowisko, site 14-15). The absolute chronology of the beginning of the late phase (III) LBK was established to be 5100-5000 BC, and the classic phase (Ib) of MC was dated to 4650-4550 BC. Selected threads of the cultural tradition (in the field of ceramic-making technology and ornamentation and flint-blade production technology) were passed on among families living in individual houses. Settlement analysis showed the relative instability of microregions, the increased mobility of small groups of people, and risky colonization attempts in Targowisko region. No evidence of direct, contemporaneous contact between the LBK and MC populations was found.
Key words: LBK, Malice culture, early Neolithic, culture change, Targowisko region
Клинический случай: эффективность биорегуляционной терапии рецидивирующего обструктивного бронхита.
Authors: Санталова Галина 
Published: December 2021

Болезни органов дыхания занимают лидирующее положение среди детского населения. Важную роль играют острые респираторные инфекции (ОРВИ). Нередко ОРВИ сопровождаются симптоматикой обструктивного бронхита.
Значимым звеном в патогенезе бронхообструкции является нарушение состояния и важных функций слизистой оболочки бронхов: снижение их резистентности к воздействию патогенных микроорганизмов, нарушение метаболизма, противовирусного и регуляторного действия [1]. В представленном клиническом случае рассматривается альтернативный подход к терапии рецидивирующего обструктивного бронхита у пациента 14 лет. В схему лечения входили препараты, относящиеся к биорегуляционной терапии (Мукоза компзитум, Эуфрбиум композитум, Энгистол), которые в значительной степени способствовали улучшению адаптационных механизмов, восстановлению бронхиальной проходимости и легочной вентиляции.
Study on Citizen Participation in Local Governance in Vietnam
Authors: Binh Nguyen Trong , Giai Nguyen Quang 
Published: December 2021

Abstract
Reform to establish a democratic, citizen-centered government is an important orientation in the world and in Vietnam today. For Vietnam, how to promote and strengthen democratic governance must be one of the most crucial issues in order to achieve sustainable development goals. Based on the theoretical framework and survey results, this study evaluates citizen participation in local governance in Vietnam on seven main dimensions, including: (i) Transparency aims to ensure citizens’ right to know; (ii) Participation in elections; (iii) Outlining of policy initiatives; (iv) Policy discussion, social criticism and referendums; (v) Voluntary contributions and cooperation with the government in public-service delivery; (vi) Social self-governance; (vii) Supervision of the social realm. Research shows that the dominance of local government is very evident in the process of citizen participation. The policy implications for countries in transition like Vietnam are that, in order to increase citizen participation in local governance, the openness of local government should be enhanced. Of course, doing this well needs a certain social basis.
Epochê e Época no pensamento logotectónico
Authors: Brainard Marcus 
Published: December 2021

Abstract
This article deals with “epoch” and “epoché”, each of which plays a central role in Heribert Boeder’s thought. Because it understands itself as the building of rational wholes, or logoi, his thought - but also that which it builds - is termed the “logotectonic”. The first part of the article situates the logotectonic epoché in the phenomenological tradition, particularly with respect to its key manifestations in Husserl and Heidegger, while also setting it off from that tradition. It is shown to be not a method of access to consciousness, to say nothing of a withholding of Being, but rather a fundamental reticence on the part of the inquirer with respect to what has been thought. It is an exclusion of one’s idiosyncrasies in order to approach what has been thought in and on its own terms. It is this new epoché, and it atone, that gives access to the epoch in Boeder’s sense. Each of three epochs of philosophy is governed by a unique principle, which is given voice in the wisdom proper to that epoch atone and to which philosophy responds (either negatively or positively). The character of this response is the basis of Boeder’s claim that the history of philosophy is the “crisis of principles.” The principle of a given epoch determines the tasks to be accomplished by the philosophy of that epoch. Once the full range of tasks is completed, the epoch is concluded, making way for a new principle and thus a new epoch. The succession of epochs comes to an end, however - in Hegel. In view of this end, the article then takes up the subsequent “periods” of thought: modernity and submodernity; it seeks to show briefly how neither constitutes an epoch, but also how the end of submodernity coincides with the opening up of the possibility of rescuing wisdom from its oblivion and granting it a present that makes dwelling possible once again. This is precisely task that moves the logotect and, by extension, the logotectonic.
Heribert Boeder, Parménides e a consolidação da filosofia
Authors: Costa Alexandre 
Published: December 2021

Abstract
The aim of this essay is to demonstrate, by means of an analysis of Parmenides’ poem, that one of the great strength’s of Heribert Boeder’s thought is his historical conception of the development of philosophical ideas. In each phase or epoch of this development, three kinds of reason arise (natural, mundane, conceptual), each of which in its own way contributes to the accomplishment of the central tasks of that epoch and thereby to the conclusion of that epoch; furthermore, each kind of reason arises as a figure composed of three rational positions that work together to complete a given task; lastly, each kind of reason has its own tradition within the history of philosophy, a tradition that extends from epoch to epoch and helps to unify that history. To grasp the historical movement of philosophy in this way is, in Boeder’s terms, “to think logotectonically”. The analysis Parmenides’ thought here shows how it inheres in the history of philosophy and what is to be gained by thinking his thought logotectonically.
Mathematical model and algorithm for calculating the cycles of the cells of the graph map
Authors: Иванов Б.Н. 
Published: December 2021

Выделенные свойства циклов DFS-базиса блока карты простого графа позволили составить математическую модель вычисления циклов ячеек карты графа. По данной модели предложен практический алгоритм вычисления циклов ячеек карты графа. Алгоритм имеет квадратическую сложность относительно числа вершин в графе.
The selected properties of the cycles of the DFS-basis block of a simple graph map allowed us to create a mathematical model for calculating the cycles of the cells of the graph map. According to this model, a practical algorithm for calculating the cycles of the graph map cells is proposed. The algorithm has a quadratic complexity relative to the number of vertices in the graph.
Cumulative Effects of a Week’s Training Loads on Shoulder Physical Qualities and Wellness in Competitive Swimmers
Authors: Yoma Matias , Herrington Lee , Mackenzie Tanya Anne 
Published: December 2021

Background Competitive swimmers are exposed to high training loads, which can contribute to the development of shoulder pain. There is a lack of research investigating the interactions between the accumulation of training loads and factors associated to shoulder pain in swimmers. Purpose The primary objective was to analyze the changes in shoulder physical qualities and wellness factors over a week of training in competitive swimmers. A secondary objective was to compare the changes in these variables between different swim-training volumes performed during the week. Design Cross-sectional. Methods Thirty-one national and regional-level swimmers were included (18 females, 13 males; age= 15.5 ± 2.2 years). Active shoulder external rotation (ER) range of motion (ROM), shoulder-rotation isometric torque, and wellness factors using the Hooper questionnaire were measured twice over the week: a baseline measurement (before Monday´s training session) and a follow-up during the week. Participants were divided into a high-volume group (HVG) and low-volume group (LVG) based on the day follow-up was performed. HVL (n= 15) was tested at the end of the training week (after Saturday´s session) and LVG (n= 16) during the week (after Thursday or Friday´s session). Rating of perceived exertion (RPE) of the whole week was recorded after the follow-up session. Results At follow-up, the LVG averaged a volume of 26.2 ± 2.2 km, whereas the HVG averaged a volume of 37.5 ± 3.7 km. LVG and HVG participants decreased active shoulder ER ROM on dominant (p= 0.002; p= 0.006) and nondominant sides (p= 0.001; p= 0.004), displayed increased muscular soreness (p= 0.001; p= 0.007) and worsened overall wellness (p< 0.001; p= 0.010). Fatigue (p= 0.008) and poor sleep quality were increased (p= 0.023) in HVG, but not in LVG. There were no changes in shoulder-rotation torque and stress in any group. Regarding between-groups differences, only weekly RPE was higher (p= 0.004) in HVG. Conclusions The accumulation of training loads over the week negatively affect physical and wellness factors. Greater swim-volumes were associated with an increase perception of training loads. The regular monitoring of multiple factors to assess swimmers’ response to training might be necessary. Level of evidence 3
PEMULANGAN “WARGA NEGARA INDONESIA EKS ISLAMIC STATE OF IRAQ AND SYRIA (ISIS)” DALAM PERSPEKTIF HAM
Authors: Maryani Lina , Sulistyo Tabah 
Published: December 2021

<p>Penelitian ini bertujuan untuk menganalisis fenomena ISIS dan pemulangan “Warga Negara Indonesia Eks ISIS” dari sudut pandang ketatanegaraan secara umum dan HAM guna memberikan pertimbangan dalam pengambilan keputusan tentang nasib Warga Negara Indonesia Eks ISIS. Berangkat dari permasalahan berakhirnya ISIS membawa Warga Negara Indonesia Eks ISIS menjadi terlantar. Radikalisme sebagai bentuk ideologi ekstrim yang disematkan pada organisasi ISIS dan kental dengan kekerasan serta anti terhadap negara membuat pemerintah enggan untuk memulangkan Warga Negara Indonesia Eks ISIS. Pemerintah Indonesia sampai sekarang belum memutuskan nasib “Warga Negara Indonesia Eks ISIS yang masih berada Suriah dan sekitarnya”. Metode penelitian menggunakan pendekatan yuridis normatif. Penelitian ini menyimpulkan bahwa dari segi pemenuhan atas syarat deklarasi Montevideo ISIS bukan negara. Dalam perspektif HAM, ISIS lebih tepat disebut dijuluki terorisme yang melakukan pelanggaran HAM berat dan dapat dikategorikan sebagai penjahat perang sebagaimana Hukum Humaniter Internasional. Langkah pemulangan Warga Negara Indonesia Eks ISIS adalah bentuk tanggungjawab Indonesia dalam menjaga ketertiban dunia dengan menindak warga negaranya yang melakukan kejahatan transnasional.</p>
KEDUDUKAN KOMISI PEMBERANTASAN KORUPSI DALAM SISTEM KETATANEGARAAN DI INDONESIA
Authors: Sadono Bambang , Lubab Ali , Arifin Zaenal , Sukarna Kadi 
Published: December 2021

<p>Penelitian ini bertujuan untuk mengkaji bagaimana kedudukan Komisi Pemberantasan Korupsi dalam sistem ketatatnegaraan di Indonesia. Salah satu hasil dari Perubahan Undang-undang Dasar Negara Republik Indonesia Tahun 1945 UUD Negara RI Tahun 1945 adalah beralihnya supremasi Majelis Permusyawaratan Rakyat (MPR) menjadi supremasi konstitusi. Sementara itu, konstitusi diposisikan sebagai hukum tertinggi yang mengatur dan membatasi kekuasaan lembaga-lembaga negara. Penelitian ini menggunakan menggunakan metode penelitian yuridis normatif. Perkembangan konsep <em>trias politica </em>juga turut memengaruhi perubahan struktur kelembagaan di Indonesia. Untuk menjawab tuntutan tersebut, negara membentuk jenis lembaga negara baru yang diharapkan dapat lebih responsif dalam mengatasi persoalan aktual negara. Maka, berdirilah berbagai lembaga negara salah satunya adalah Komisi Pemberantasan Korupsi (KPK) keberadaan yang keberadaannya dalam struktur ketatanegaraaan di negeri ini sering menjadi perdebatkan oleh berbagai pihak karena Komisi Pemberantasan Korupsi Sifat yang independen dan bebas dari pengaruh kekuasaan. Permasalahan yang ingin dijawab dalam penelitian ini adalah Kedudukan Komisi Pemberantasan Korupsi dalam Sistem Ketatanegaraan di Indonesia saat ini dan Kedudukan Komisi Pemberantasan Korupsi yang seharusnya dalam Sistem Ketatanegaraan di Indonesia,teori yang di gunakan dalam penelitian ini adalah <em>trias politica dan kepastian h</em><em>u</em><em>kum, </em> penelitian ini adalah penelitian<em> </em>hukum normatif. Kesimpulan penelitian ini adalah keberadaan lembaga Komisi Pemberantasan Korupsi secara yuridis adalah sah berdasarkan konstitusi dan secara sosiologis telah menjadi kebutuhan bangsa dan Negara Republik Indonesia. Untuk mewujudkan Komisi Pemberantasan Kosupsi bebas dari pengaruh kekuasaan manapun dan Kedududukan Komisi Pemberantasan Korupsi dalam sistem ketatanegaran di Indonesia akan menjadi lebih kuat maka kedudukannya menjadi organ konstitusi (<em>constitusional organs</em>) atau masuk kedalam konstitusi maka di perlukan Amandemen Undang-undang Dasar Negara Republik Indonesia Tahun 1945.</p>
KEBIJAKAN HUKUM PERUBAHAN BATASAN MINIMAL UMUR PERNIKAHAN PERSPEKTIF HUKUM ISLAM
Authors: Aristoni Aristoni 
Published: December 2021

<p> </p><p>Tulisan artikel ini bertujuan menjelaskan tentang konsep umur pernikahan dalam hukum Islam dan hukum nasional, kebijakan hukum“Undang-Undang Nomor 1 Tahun 1974” dalam lintasan sejarah, pengaturan batasan minimal umur pernikahan dalam Undang-Undang Perkawinan, dan kebijakan hukum perubahan batasan umur pernikahan dalam pandangan hukum Islam. Tulisan artikel ini dapat dikategorikan sebagai jenis riset kepustakaan dengan menggunakan metode penelitian kualitatif sebagai basisnya. Hasil kajian penelitian menunjukkan bahwa ketentuan umur perkawinan baik dalam hukum Islam maupun hukum nasional masing-masing terjadi perbedaan utamanya dalam penentuan batas ukuran kedewasaan. Perbedaan batas ukuran kedewasaan dalam hukum Islam terjadi karena secara eksplisit Al-Qur’an tidak menjelaskannya, sedangkan perbedaan ketentuan umur kedewasaan seseorang dalam hukum nasional disebabkan salah satu adalah lemahnya koordinasi dan pelibatan berbagai pihak dalam pembentukan peraturan perundang-undangan. Kebijakan hukum mengenai“Undang-Undang Nomor 1 Tahun 1974” sejak awal hakikatnya diarahkan untuk mengadakan unifikasi hukum dalam permasalahan hukum perkawinan yang beragam dan berlaku bagi masyarakat Indonesia tanpa menghilangkan kebhinekaan yang didasarkan pada falsafah Pancasila dan “Undang-Undang Dasar NRI Tahun 1945.”Pengaturan perubahan batasan minimal umur perkawinan dengan segala tujuan yang positif hakikatnya memberikan jaminan keadilan, kepastian, dan kemanfaatan dari tujuan hukum diciptakan. Kebijakan hukum perubahan batasan minimal umur pernikahan dengan menyamakan umur pernikahan antara laki-laki dan perempuan 19 Tahun dalam pandangan hukum Islam dapat dikatakan bernilai kemaslahatan yaitu menjaga keberadaan jiwa, keturunan, dan akal (<em>maqashid syariah)</em> dan menghindarkan perempuan dari bahaya kerusakaan <em>(mazharat)</em> yang lebih besar akibat perkawinaan usia anak sebagaimana tertuang dalam konsideran“Undang-Undang Nomor 16 Tahun 2019 tentang Perkawinan.</p>