bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extracellular Vesicles as an Emerging Treatment Option for Intervertebral Disc Degeneration: Therapeutic Potential, Translational Pathways, and Regulatory Considerations
Authors: DiStefano Tyler J. , Vaso Keti , Danias George , Chionuma Henry N. , Weiser Jennifer R. , Iatridis James C. 
Published: July 2021

AbstractEmergent approaches in regenerative medicine look toward the use of extracellular vesicles (EVs) as a next‐generation treatment strategy for intervertebral disc (IVD) degeneration (IVDD) because of their ability to attenuate chronic inflammation, reduce apoptosis, and stimulate proliferation in a number of tissue systems. Yet, there are no Food and Drug Administration (FDA)‐approved EV therapeutics in the market with an indication for IVDD, which motivates this article to review the current state of the field and provide an IVD‐specific framework to assess its efficacy. In this systematic review, 29 preclinical studies that investigate EVs in relation to the IVD are identified, and additionally, the regulatory approval process is reviewed in an effort to accelerate emerging EV‐based therapeutics toward FDA submission and timeline‐to‐market. The majority of studies focus on nucleus pulposus responses to EV treatment, where the main findings show that stem cell‐derived EVs can decelerate the progression of IVDD on the molecular, cellular, and organ level. The findings also highlight the importance of the EV parent cell's pathophysiological and differentiation state, which affects downstream treatment responses and therapeutic outcomes. This systematic review substantiates the use of EVs as a promising cell‐free strategy to treat IVDD and enhance endogenous repair.
Second Near‐Infrared Light‐Activatable Polymeric Nanoantagonist for Photothermal Immunometabolic Cancer Therapy
Authors: Xu Cheng , Jiang Yuyan , Huang Jingsheng , Huang Jiaguo , Pu Kanyi 
Published: July 2021

AbstractImmunometabolic modulation offers new opportunities to treat cancers as it is highly associated with cancer progression and immunosuppressive microenvironment. However, traditional regimens using nonselective small‐molecule immunomodulators lead to the off‐target adverse effects and insufficient therapeutic outcomes. Herein a second near‐infrared (NIR‐II) photothermally activatable semiconducting polymeric nanoantagonist (ASPA) for synergistic photothermal immunometabolic therapy of cancer is reported. ASPA backbone is obtained by conjugating vipadenant, an antagonist to adenosine A2A receptor, onto NIR‐II light‐absorbing semiconducting polymer via an azo‐based thermolabile linker. Under deep‐penetrating NIR‐II photoirradiation, ASPA induces tumor thermal ablation and subsequently immunogenic cell death, triggers the cleavage of thermolabile linker, and releases the antagonist to block the immunosuppressive adenosinergic pathway. Such a remotely controlled immunometabolic regulation potentiates cytotoxic T cell functions while suppresses regulatory T cell activities, leading to efficient primary tumor inhibition, pulmonary metastasis prevention, and long‐term immunological memory. Thereby, this work provides a generic polymeric approach for precise spatiotemporal regulation of cancer immunometabolism.
Sulfoxide‐Controlled Stereoselective Aza‐Piancatelli Reaction
Authors: Marin Lucile , Jerhaoui Soufyan , Kolodziej Emilie , Guillot Régis , Gandon Vincent , Colobert Françoise , Schulz Emmanuelle , Wencel‐Delord Joanna , Lebœuf David 
Published: July 2021

AbstractThe development of a stereoselective aza‐Piancatelli reaction to access 4‐aminocyclopentenones is reported. This transformation relies on the use of chiral o‐sulfinyl anilines as chiral inductors to afford the targeted products in good to excellent yields. Remarkably, the high value‐added cyclopentenones could be obtained in drs up to >95:5, depending upon the furan substitution pattern.magnified image
Visible‐Light‐Mediated Nitrogen‐Centered Radical Strategy: Preparation of 3‐Acylated Spiro[4,5]trienones
Authors: Chen Pu , Xie Jun , Chen Zan , Xiong Bi‐Quan , Liu Yu , Yang Chang‐An , Tang Ke‐Wen 
Published: July 2021

AbstractA nitrogen‐centered radical strategy for the preparation of 3‐acylated spiro[4,5]trienones via visible‐light‐mediated acylation/ipso‐cyclization of alkynes with acyl oxime esters is reported. The alkyl‐ and aryl‐substituted acyl radicals, which generate from the cleavage of carbon‐carbon σ‐bonds in acyl oxime esters via nitrogen‐centered radical pathway, attack the carbon‐carbon triple bonds in propiolamides and then undergo ipso‐cyclization. This method provides a way for the construction of 3‐acyl‐substituted spiro[4,5]trienones, which can introduce aryl‐ or alkyl‐substituted acyl into spiro[4,5]trienone skeletons.magnified image
Photothermal Therapy Combined with Neoantigen Cancer Vaccination for Effective Immunotherapy against Large Established Tumors and Distant Metastasis
Authors: Nam Jutaek , Son Sejin , Park Kyung Soo , Moon James J. 
Published: July 2021

AbstractPhotothermal therapy (PTT) and neoantigen cancer vaccine each offer minimally invasive and highly specific cancer therapy; however, they are not effective against large established tumors due to physical and biological barriers that attenuate thermal ablation and abolish antitumor immunity. Here, comparative study is designed and performed using small (≈50 mm3) and large (>100 mm3) tumors to examine how tumor size affects the therapeutic efficiency of PTT and neoantigen cancer vaccine. It is shown that spiky gold nanoparticle (SGNP)‐based PTT and synergistic dual adjuvant‐based neoantigen cancer vaccine can efficiently regress small tumors as a single agent, but not large tumors due to limited internal heating and immunosuppressive tumor microenvironment (TME). It is reported that PTT sensitizes tumors to neoantigen cancer vaccination by destroying and compromising the TME via thermally induced cellular and molecular damage, while neoantigen cancer vaccine reverts local immune suppression induced by PTT and shapes residual TME in favor of antitumor immunity. The combination therapy efficiently eradicates large local tumors and also exerts strong abscopal effect against pre‐established distant tumors with robust systemic antitumor immunity. Thus, PTT combined with neoantigen cancer vaccine is a promising nano‐immunotherapy for personalized therapy of advanced cancer.
Concentrated Electrolytes Widen the Operating Temperature Range of Lithium‐Ion Batteries
Authors: Wang Jianhui , Zheng Qifeng , Fang Mingming , Ko Seongjae , Yamada Yuki , Yamada Atsuo 
Published: July 2021

AbstractThe operating temperatures of commercial lithium‐ion batteries (LIBs) are generally restricted to a narrow range of −20 to 55 °C because the electrolyte is composed of highly volatile and flammable organic solvents and thermally unstable salts. Herein, the use of concentrated electrolytes is proposed to widen the operating temperature to −20 to 100 °C. It is demonstrated that a 4.0 mol L−1 LiN(SO2F)2/dimethyl carbonate electrolyte enables the stable charge–discharge cycling of a graphite anode and a high‐capacity LiNi0.6Co0.2Mn0.2O2 cathode and the corresponding full cell in a wide temperature range from −20 to 100 °C owing to the highly thermal stable solvation structure of the concentrated electrolyte together with the robust and Li+‐conductive passivation interphase it offered that alleviate various challenges at high temperatures. This work demonstrates the potential for the development of safe LIBs without the need for bulky and heavy thermal management systems, thus significantly increasing the overall energy density.
Inkjet Printing of Perovskite Nanosheets for Microcapacitors
Authors: Fu Yushui , Zhang Pengxiang , Li Bao‐Wen , Zhang Binbin , Yu Yimeng , Shen Zhonghui , Zhang Xin , Wu Jinsong , Nan Ce‐Wen , Zhang Shujun 
Published: July 2021

AbstractDielectric capacitors are an essential passive component widely used in integrated circuits. Recently, inkjet printing of 2D nanosheets into highly insulating layers has been developed for capacitor applications. However, the relatively low dielectric constant inherently associated with 2D nanosheets will hinder the rational design of high‐performance capacitor devices. In this work, the inks of high‐k Ca2NaNb4O13 perovskite nanosheets are formulated, and all‐printed dielectric capacitor consisting of Ca2NaNb4O13 films with commercial Ag electrodes is demonstrated. An average areal capacitance of ≈21 nF cm−2, together with low current density (<10−7 A cm−2) and low dielectric loss (≈2%), is achieved for the dielectric layer with thickness of ≈2 µm. The research shows that high‐k perovskite nanosheets have a great potential for applications in ink‐based additive manufacturing of flexible electronic devices.
A nuclear phylogenomic study of the angiosperm order Myrtales, exploring the potential and limitations of the universal Angiosperms353 probe set
Authors: Maurin Olivier , Anest Artemis , Bellot Sidonie , Biffin Edward , Brewer Grace , Charles‐Dominique Tristan , Cowan Robyn S. , Dodsworth Steven , Epitawalage Niroshini , Gallego Berta , Giaretta Augusto , Goldenberg Renato , Gonçalves Deise J.P. , Graham Shirley , Hoch Peter , Mazine Fiorella , Low Yee Wen , McGinnie Catherine , Michelangeli Fabián A. , Morris Sarah , Penneys Darin S. , Pérez Escobar Oscar Alejandro , Pillon Yohan , Pokorny Lisa , Shimizu Gustavo , Staggemeier Vanessa G. , Thornhill Andrew H. , Tomlinson Kyle W. , Turner Ian M. , Vasconcelos Thais , Wilson Peter G. , Zuntini Alexandre R. , Baker William J. , Forest Félix , Lucas Eve 
Published: July 2021

PremiseTo further advance the understanding of the species‐rich, economically and ecologically important angiosperm order Myrtales in the rosid clade, comprising nine families, approximately 400 genera and almost 14,000 species occurring on all continents (except Antarctica), we tested the Angiosperms353 probe kit.MethodsWe combined high‐throughput sequencing and target enrichment with the Angiosperms353 probe kit to evaluate a sample of 485 species across 305 genera (76% of all genera in the order).ResultsResults provide the most comprehensive phylogenetic hypothesis for the order to date. Relationships at all ranks, such as the relationship of the early‐diverging families, often reflect previous studies, but gene conflict is evident, and relationships previously found to be uncertain often remain so. Technical considerations for processing HTS data are also discussed.ConclusionsHigh‐throughput sequencing and the Angiosperms353 probe kit are powerful tools for phylogenomic analysis, but better understanding of the genetic data available is required to identify genes and gene trees that account for likely incomplete lineage sorting and/or hybridization events.
Cutaneous T‐cell lymphomas: 2021 update on diagnosis, risk‐stratification, and management
Authors: Hristov Alexandra C. , Tejasvi Trilokraj , A. Wilcox Ryan 
Published: July 2021

AbstractDisease overviewCutaneous T‐cell lymphomas are a heterogenous group of T‐cell neoplasms involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS).DiagnosisThe diagnosis of MF or SS requires the integration of clinical and histopathologic data.Risk‐adapted therapyTNMB (tumor, node, metastasis, blood) staging remains the most important prognostic factor in MF/SS and forms the basis for a “risk‐adapted,” multi‐disciplinary approach to treatment. For patients with disease limited to the skin, expectant management or skin‐directed therapies is preferred, as both disease‐specific and overall survival for these patients is favorable. In contrast, patients with advanced‐stage disease with significant nodal, visceral or blood involvement are generally approached with systemic therapies, including biologic‐response modifiers, histone deacetylase inhibitors, or antibody‐based strategies, in an escalating fashion. In highly‐selected patients, allogeneic stem‐cell transplantation may be considered, as this may be curative in some patients.
Molecularly Imprinted Polymer Nanogels for Protein Recognition: Direct Proof of Specific Binding Sites by Solution STD and WaterLOGSY NMR Spectroscopies
Authors: Mier Alejandra , Maffucci Irene , Merlier Franck , Prost Elise , Montagna Valentina , Ruiz‐Esparza Guillermo U. , Bonventre Joseph V. , Dhal Pradeep K. , Tse Sum Bui Bernadette , Sakhaii Peyman , Haupt Karsten 
Published: July 2021

AbstractMolecularly imprinted polymers (MIPs) are tailor‐made synthetic antibodies possessing specific binding cavities designed for a target molecule. Currently, MIPs for protein targets are synthesized by imprinting a short surface‐exposed fragment of the protein, called epitope or antigenic determinant. However, finding the epitope par excellence that will yield a peptide “synthetic antibody” cross‐reacting exclusively with the protein from which it is derived, is not easy. We propose a computer‐based rational approach to unambiguously identify the “best” epitope candidate. Then, using Saturation Transfer Difference (STD) and WaterLOGSY NMR spectroscopies, we prove the existence of specific binding sites created by the imprinting of this peptide epitope in the MIP nanogel. The optimized MIP nanogel could bind the epitope and cognate protein with a high affinity and selectivity. The study was performed on Hepatitis A Virus Cell Receptor‐1 protein, also known as KIM‐1 and TIM‐1, for its ubiquitous implication in numerous pathologies.
Conductive and antibacterial cellulose nanofibers decorated with copper nanoparticles for potential application in wearable devices
Authors: Hussain Nadir , Mehdi Mujahid , Siyal Sajid Hussain , Wassan Rano Khan , Hashemikia Samaneh , Sarwar Muhammad Nauman , Yamaguchi Takumi , Kim Ick Soo 
Published: July 2021

AbstractOne of the contributions of nanotechnology to our daily life is the preparation of a large variety of polymer‐based nanofibers, which could be the basis of future wearable devices. Wearable electronics are a great part of smart textiles research. Herein, we have reported an easy method to fabricate electrically conductive cellulose nanofibers (CNFs). To fabricate CNFs, we first prepared cellulose acetate (CA) nanofibers by using the electrospinning technique and later, the deacetylation process was done to obtain the CNFs. The electroless deposition (ELD) technique was then used to create the conductive nanofibers. Copper (Cu) was used to coat the CNFs because of their high conductivity and low cost. The ELD process parameters including time, temperature, volume, and pH were optimized to obtain a nanofiber with higher conductivity. The optimized condition was temperature: 40 °C, time: 10 min, volume: 600 ml, and pH: 13 to obtain a nanofiber web with 983.5 S/cm conductivity. Cu‐coated CNFs were characterized by scanning electron microscope, energy‐dispersive X‐ray spectroscopy, Fourier‐transform infrared spectroscopy, water contact angle, antibacterial activity, tensile, and electrical conductivity. The bending cycle test was performed to quantitatively demonstrate the durability and flexibility of the Cu‐coated nanofibers. Cu‐coated CNFs exhibited great performance to be used as a conductive layer with antibacterial activity.
Petroglyphs and place: complex histories at four sites in New Britain
Authors: SPECHT JIM , TORRENCE ROBIN , MULVANEY KEN 
Published: July 2021

ABSTRACTThe analysis of cultural practices at four sites near Cape Gloucester and on Uneapa and Garua Islands in West New Britain, Papua New Guinea shows how rock markings and boulder arrangements create special places within physical and social landscapes. Four kinds of rock markings are documented: cupules, abraded surfaces, geometric curvilinear and rectilinear (i.e., composed of straight lines) petroglyphs, and figurative forms including anthropomorphic heads and introduced animals. The placement of the art, together with the arrangement of boulders, implies that both restricted and open forms of ceremony were conducted. The similarities between these sites suggest the existence of a precursor to the well‐documented recent interaction zone in this part of West New Britain. We speculate that these cultural practices have a much longer history than previously proposed for Island Melanesia.
Acceptorless Photocatalytic Dehydrogenation of Furfuryl Alcohol (FOL) to Furfural (FAL) and Furoic Acid (FA) over Ti3C2Tx/CdS under Visible Light
Authors: Wang Jiaqi , Liu Xinyu , Li Zhaohui 
Published: July 2021

AbstractAcceptorless photocatalytic dehydrogenation is not only a promising alternative to photocatalytic water splitting for hydrogen generation but also provides a green and sustainable strategy for the synthesis of value‐added organic compounds. In this work, Ti3C2Tx/CdS nanocomposites were obtained by self‐assembly of hexagonal CdS in the presence of preformed Ti3C2Tx nanosheets, which serves as a photocatalyst for acceptorless dehydrogenation of biomass‐derived furfuryl alcohol (FOL) to furfural (FAL) and furoic acid (FA) in neutral and alkaline medium respectively, with simultaneous generation of stoichiometric hydrogen under visible light. Ti3C2Tx MXene acts as an efficient cocatalyst for the photocatalytic dehydrogenation of FOL over CdS, with an optimum performance achieved over 0.50 wt% Ti3C2Tx/CdS nanocomposite. This study provides an economic and sustainable strategy for the simultaneous valorization of biomass‐derived FOL to produce FAL and FA as well as the production of clean energy hydrogen under mild condition based on noble metal‐free semiconductor‐based photocatalysts.
Examining the role of risk in waiting preference and dynamic preference reversal: An experience intertemporal choice study
Authors: Xu Ping , Vincent Benjamin T. , Sang Hui , Li Xiaodong 
Published: July 2021

AbstractShort waits are pervasive in modern life. This study addressed how risk impacts intertemporal decisions that involve short waits (of 72 s or less) and how those decisions change while waiting. We used an experience time‐discounting task sensitive to the impact of risk and which can measure intratrial preference reversals. Three experiments showed that (1) adding uncertainty to outcomes does not change participants' preferences in waiting for a reward, but it reduces their willingness in waiting for a reduction of losses; (2) adding uncertainty to outcomes increases participants' tendency to switch their decisions during the course of waiting; and (3) participants showed no gain–loss asymmetry for risky intertemporal choices.
Maternal exposure to hydroxychloroquine and birth defects
Authors: Howley Meredith M. , Werler Martha M , Fisher Sarah C , Van Zutphen Alissa R , Carmichael Suzan L , Broussard Cheryl S , Heinke Dominique , Ailes Elizabeth C , Pruitt Shannon M , Reefhuis Jennita , Mitchell Allen A. , Browne Marilyn L. ,   the National Birth Defects Prevention Study
Published: July 2021

AbstractBackgroundHydroxychloroquine is a treatment for rheumatic disease and considered safe during pregnancy. Interest in hydroxychloroquine has increased as it is being examined as a potential treatment and prophylaxis for coronavirus disease 2019. Data on the risks of specific birth defects associated with hydroxychloroquine use are sparse.MethodsUsing data from two case–control studies (National Birth Defects Prevention Study and Slone Epidemiology Center Birth Defects Study), we described women who reported hydroxychloroquine use in pregnancy and the presence of specific major birth defects in their offspring. Cases had at least one major birth defect and controls were live‐born healthy infants. Women self‐reported medication use information in the few months before pregnancy through delivery.ResultsIn total, 0.06% (19/31,468) of case and 0.04% (5/11,614) of control mothers in National Birth Defects Prevention Study, and 0.04% (11/29,838) of case and 0.05% (7/12,868) of control mothers in Birth Defects Study reported hydroxychloroquine use. Hydroxychloroquine users had complicated medical histories and frequent medication use for a variety of conditions. The observed birth defects among women taking hydroxychloroquine were varied and included nine oral cleft cases; the elevated observed:expected ratios for specific oral cleft phenotypes and for oral clefts overall had 95% confidence intervals that included 1.0.ConclusionWhile teratogens typically produce a specific pattern of birth defects, the observed birth defects among the hydroxychloroquine‐exposed women did not present a clear pattern, suggesting no meaningful evidence for the risk of specific birth defects. The number of exposed cases is small; results should be interpreted cautiously.
Full‐length G glycoprotein directly extracted from rabies virus with detergent and then stabilized by amphipols in liquid and freeze‐dried forms
Authors: Clénet Didier , Clavier Léna , Strobbe Benoît , Le Bon Christel , Zoonens Manuela , Saulnier Aure 
Published: July 2021

AbstractPathogen surface antigens are at the forefront of the viral strategy when invading host organisms. These antigens, including membrane proteins (MPs), are broadly targeted by the host immune response. Obtaining these MPs in a soluble and stable form constitutes a real challenge, regardless of the application purposes (e.g. quantification/characterization assays, diagnosis, and preventive and curative strategies). A rapid process to obtain a native‐like antigen by solubilization of a full‐length MP directly from a pathogen is reported herein. Rabies virus (RABV) was used as a model for this demonstration and its full‐length G glycoprotein (RABV‐G) was stabilized with amphipathic polymers, named amphipols (APols). The stability of RABV‐G trapped in APol A8‐35 (RABV‐G/A8‐35) was evaluated under different stress conditions (temperature, agitation, and light exposure). RABV‐G/A8‐35 in liquid form exhibited higher unfolding temperature (+6°C) than in detergent and was demonstrated to be antigenically stable over 1 month at 5°C and 25°C. Kinetic modeling of antigenicity data predicted antigenic stability of RABV‐G/A8‐35 in a solution of up to 1 year at 5°C. The RABV‐G/A8‐35 complex formulated in an optimized buffer composition and subsequently freeze‐dried displayed long‐term stability for 2‐years at 5, 25, and 37°C. This study reports for the first time that a natural full‐length MP extracted from a virus, complexed to APols and subsequently freeze‐dried, displayed long‐term antigenic stability, without requiring storage under refrigerated conditions.
Circular economy in corporate sustainability reporting: A review of organisational approaches
Authors: Opferkuch Katelin , Caeiro Sandra , Salomone Roberta , Ramos Tomás B. 
Published: July 2021

AbstractA growing commitment from companies to implement circular economy (CE) strategies demands the development of guidelines for consistent related external communication. The fields of non‐financial reporting and sustainability are well established with numerous available international reporting frameworks and approaches; however, there is still an absence of standardised reporting principles and procedures for publishing progress on circularity. In this context, this article aims to explore how companies could include CE within their corporate sustainability reports, through an academic literature review and content analysis of existent reporting approaches. Results showed a clear disconnection between CE and sustainability reporting literature. Overall, only a few of the revised reporting approaches explicitly mention CE, and the guidance given to companies is very general, inconsistent and places the responsibility of selecting performance assessment approaches on the companies. The analysis contributes to identifying opportunities for transparent external communication of CE issues, as well as exploring the challenges and limitations.