bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kecanduan Gadget di Masa Pandemi covid-19 pada Siswa Kelas XII MIPA SMAN 1 Sutojayan Kabupaten Blitar
Authors: Bintari Ramadhanti Husnah 
Published: October 2021

Adanya pandemi Covid-19 menuntut adanya pembelajaran secara daring dengan menggunakan gadget ternyata menimbulkan dampak negatif yaitu siswa terstimulasi mengakses aplikasi lain sehingga meningkatkan kenyamanan dan kemampuan eksplorasi siswa pada penggunaan internet. Hal ini meningkatkan resiko kecanduan pada siswa. Tujuan penelitian ini adalah mengetahui tingkat kecanduan gadget di masa pandemi Covid-19 pada siswa kelas XII MIPA SMAN 1 Sutojayan Kabupaten Blitar.
Penelitian ini merupakan penelitian deskriptif. Populasinya seluruh siswa kelas XII MIPA SMAN 1 Sutojayan Kabupaten Blitar dengan total 176 orang. Jumlah sampel 122 responden, dengan teknik sampling proportional random sampling. Variabel yang diteliti adalah tingkat kecanduan gadget di masa pandemi Covid-19. Instrumen penelitian yang digunakan adalah kuesioner SAS (Smartphone Addiction Scale). Analisa data menggunakan analisis univariat.
Hasil penelitian menunjukkan sebagian besar responden berada pada tingkat kecanduan sedang yaitu 93 responden (75%), sebagian kecil berada pada kategori kecanduan berat dan ringan yaitu 23 responden (20%) dan 6 responden (5%). Hasil penelitian itu dimungkinkan karena adanya sarana dan prasana yang disediakan orang tua di rumah, untuk mencari informasi,mengerjakan tugas, bermain game dan menonton vidio/film/vlog.
Oleh karena itu, pemberian konseling kepada orang tua dan siswa tentang cara bijak penggunaan gadget serta kontrol diri dan selektivitas dalam penggunaan teknologi informasi dan komunikasi. Pembinaan dan pengawasan orang tua sangat dibutuhkan untuk menurunkan resiko kecanduan pada siswa.
UJI EFEKTIVITAS ANALGESIK EKSTRAK KOMBINASI JAHE (Zingiberaceae Officinale) DAN JARAK PAGAR (Jatropha curcas) PADA MENCIT(Mus Musculus
Authors: Septiawati Dwi 
Published: October 2021

Nyeri pada dasarnya merupakan suatu reaksi fisiologis berupa reaksi protektif tubuh sebagai mekanisme untuk menghindari stimulus yang membahayakan bagi tubuh. Masyarakat saat ini menggunakan herbal sebagai pelengkap pengobatan primer yang diterima. Jahe merupakan tanaman rimpang yang memiliki banyak khasiat, salah satunya adalah sebagai analgetik dan antiinflamasi. Jarak pagar memiliki aktivitas farmakologi diantaranya melancarkan peredaran darah, menghilangkan bengkak, menghentikan pendarahan, dan menghilangkan gatal. Penelitian ini bertujuan untuk melihat perbandingan efek analgesik ekstrak kombinasi jahe dan jarak pagar dengan paracetamol. Penelitian ini merupakan penelitian eksperimental dengan kelompok perlakuan paracetamol dan kombinasi jahe dan jarak pagar. Pada penilitian ini menggunakan lima kelompokkontrol positif, control negative, dan kelompok perlakuan yaitu kelompok diberi ekstrak kombinasi jahe dan jarak pagar dengan 3 dosis berbeda yaitu 16 mg/ 20gr BB, 32 mg/20gr BB, 48 mg/20gr BB. Efek analgesik dilihat dengan menghitung jingkatan mencit dalam 5 menit, berupa mengangkat kedua kaki depannya atau meloncat ke atas setelah diberi induksi asam asetat 1%.Hasil pengamatan menunjukkan kandungan senyawa kimia pada ekstrak kombinasi jahe dan jarak pagar terbukti memiliki efek analgesik dibanding dengan kelompok kontrol.
Kata kunci: Analgesik, Paracetamol, Jahe, Jarak pagar
PERBEDAAN PENURUNAN SKALA NYERI PUNGGUNG PADA IBU HAMIL TRIMESTER III DENGAN SENAM HAMIL DAN TANPA SENAM HAMIL DI KECAMATAN MOJOSARI MOJOKERTO
Authors: Mardiana Heppy 
Published: October 2021

Pendahuluan Pada kehamilan sering muncul keluhan salah satunya nyeri punggung yang banyak dialami oleh Ibu hamil di trimester tiga. Selama pandemi covid-19 terkait dengan kebijakan pemerintah bahwa pasien hamil yang tidak urgent, tidak perlu konsultasi serta senam hamil ditiadakan. Tujuan penelitian ini adalah mengetahui perbedaan penurunan skala nyeri punggung pada ibu hamil trimester III dengan senam hamil online dan tanpa senam hamil di Desa Seduri Kecamatan Mojosari-Mojokerto.
Metode Desain yang digunakan adalah Quasy Eksperiment dengan menggunakan pendekatan two group pre-post test design.Populasi dalam penelitian ini adalah semua Ibu hamil di Desa Seduri sebanyak 40 orang. Teknik pengambilan sampel menggunakan Total sampling, terdiri dari 20 kelompok kontrol dan 20 kelompok perlakuan. Penelitian dilakukan selama 3 minggu. Senam hamil online menggunakan Google meet selama 2x/minggu dan pengumpulan data menggunakan lembar observasi.
Hasil Uji komparasi menggunakan Independent t-test, dan didapatkan hasil t hitung 0.085(sig>0.05) berarti ada perbedaan penurunan skala nyeri punggung bawah pada Ibu hamil yang melakukan senam hamil dan yang tidak melakukan senam hamil.
Kesimpulan Senam hamil perlu dilakukan oleh Ibu di rumah selama pandemi Covid 19 karena memberikan efek rileks pada tubuh, sehingga membantu mengeluarkan hormone endorphin yang membuat Ibu bahagia.

Kata kunci: Kehamilan, Senam hamil, Nyeri punggung.
Tissue Engineering Heart Valves – a Review of More than Two Decades into Preclinical and Clinical Testing for Obtaining the Next Generation of Heart Valve Substitutes
Authors: Simionescu Dan , Harpa Marius Mihai , Simionescu Agneta , Oprita Codrut , Movileanu Ionela 
Published: October 2021

Abstract
Well documented shortcomings of current heart valve substitutes – biological and mechanical prostheses make them imperfect choices for patients diagnosed with heart valve disease, in need for a cardiac valve replacement. Regenerative Medicine and Tissue Engineering represent the research grounds of the next generation of valvular prostheses – Tissue Engineering Heart Valves (TEHV). Mimicking the structure and function of the native valves, TEHVs are three dimensional structures obtained in laboratories encompassing scaffolds (natural and synthetic), cells (stem cells and differentiated cells) and bioreactors. The literature stipulates two major heart valve regeneration paradigms, differing in the manner of autologous cells repopulation of the scaffolds; in vitro, or in vivo, respectively. During the past two decades, multidisciplinary both in vitro and in vitro research work was performed and published. In vivo experience comprises preclinical tests in experimental animal model and cautious limited clinical translation in patients. Despite initial encouraging results, translation of their usage in large clinical scenarios represents the most important challenge that needs to be overcome. This review purpose is to outline the most remarkable preclinical and clinical results of TEHV evaluation along with the lessons learnt from all this experience.
The Investigation of Combined Na+/Ca2+ Exchanger and the L-type Ca2+- Channel Inhibition in Langendorff-Perfused Isolated Guinea Pig Hearts
Authors: Prorok János , Veisbart Annamária , Lipka Dóra , Jost Norbert 
Published: October 2021

Abstract

Objective
The sodium/calcium exchanger (NCX) and the L-type Ca2+-channel (LTCC) are nowadays considered the major transmembrane transport mechanisms that control Ca2+ homeostasis. In pathophysiological conditions the altered function of these currents may influence the Ca2+ homeostasis and cardiac contractility and thereby, may enhance the development of severe tachyarrhythmias. The blockade of NCX current has been proposed as possible approach in the prevention and/or suppression of arrhythmias; however, this mechanism is not always favourable because the inhibition of both modes of NCX may induce Ca2+-overload. The decrease of the Ca2+ level by partial LTCC inhibition may be beneficial in increasing the antiarrhythmic efficacy. Therefore, the aim of our study was to investigate the antiarrhythmic effects of combined NCX and LTCC blockade in the ex vivo guinea pig arrhythmia model.

Methods
We have performed Langendorff experiments in isolated guinea pig hearts. We have recorded electrocardiograms (ECG) and left ventricle pressure. We have applied 1 μM ORM-10962 (ORM), a compound that block NCX current and 30 nM nisoldipine for the inhibition of LTCC. Arrhythmias have been provoked by decreasing the activity of the sodium/potassium pump with 5 μM ouabain.

Results
We found that neither LTCC nor NCX blockade alone increased, while the combined inhibition of the two currents significantly delayed (p<0.05) the mean time of appearance of ouabain-induced ventricular fibrillation. The heart frequency was affected by none of the drugs, only the left ventricular pressure (end-systolic and diastolic difference) was significantly elevated by ORM (p<0.001).

Conclusion
In the Langendorff-perfused guinea pig heart, specific, combined NCX and LTCC blockade may be favourable than the inhibition of NCX or LTCC alone. However, further investigations are necessary to identify the pathological settings in which this combined cardiac drug therapy may be a potential new approach.
In Silico Analysis of Novel Titin Non-Synonymous Missense Variants Detected by Targeted Next-Generation Sequencing in a Cohort of Romanian Index Patients with Hypertrophic Cardiomyopathy
Authors: Micheu Miruna Mihaela , Oprescu Nicoleta , Popa-Fotea Nicoleta-Monica 
Published: October 2021

Abstract

Background and aim
Most of detected variants in cardiogenetic panels are still classified as variants of unknown significance, requiring supplementary analyses for a definite classification. Performing further in-depth studies on such vast number of candidates is unfeasible. We sought to prioritise the novel nonsynonymous missense variants identified in titin gene (TTN) in a cohort of Romanian index cases with hypertrophic cardiomyopathy (HCM).

Methods
45 unrelated probands with HCM were screened by targeted next generation sequencing (NGS) covering all TTN exons. A stepwise strategy was used to select and prioritize the candidate variants for subsequent investigation.

Results
Using rigorous bioinformatic filtering, 7 novel TTN nonsynonymous missense variants were identified and were the subject of in silico sequential analysis. 4 of the 7 variants were predicted to be possibly pathogenic by the Mendelian Clinically Applicable Pathogenicity (M-CAP) algorithm. Of these, three sequence variants (c.30392G>T, c.2518G>T, and c.49G>T) were also predicted to be destabilizing according to the second computational tool (TITINdb) and were designated as likely function-impacting.

Conclusions
Herein we presented our strategy to hand-pick the novel TTN missense variants to be considered for further experimental studies. By applying various in silico tools, we restricted the list of sequence variants to be investigated to those most likely to be disease-associated, and thus reducing the need to perform expensive and time-consuming additional studies.
BENEFÍCIOS DO SEGUIMENTO FARMACOTERAPÊUTICO PARA O TRATAMENTO DE PACIENTES COM DIABETES MELLITUS: UMA REVISÃO INTEGRATIVA
Authors: Silva Gonçalves Samantha Aparecida , Silva Simone , Bitencourt Santos Barros Gérsika 
Published: October 2021

Objetivo: Analisar o benefício do acompanhamento farmacoterapêutico durante a terapia medicamentosa e não medicamentosa de pacientes com diabetes mellitus. Métodos: Trata-se de uma revisão integrativa da literatura sobre o acompanhamento de pacientes com terapia antidiabética e que possuem ou não comorbidades secundárias. Os artigos foram analisados por meio das bases de dados, Pubmed, Scielo, Lilacs publicados entre os anos de 2016 a 2021. Resultados: Foram selecionados 20 artigos para comporem esse artigo de revisão. Os artigos correlacionam a prática do seguimento farmacoterapêutico dos pacientes de diabetes mellitus e os benefícios trazidos para a resposta terapêutica. Há também estudos sobre o benefício da atividade física associada a fármacos diabéticos que melhoraram sua glicemia de jejum, pós prandial e hemoglobina glicada. Quanto à idade observou que há um predomínio de pessoas com uma idade acima de 41 anos, 50% de 41 a 60 e 23% de 61 a 80 anos. Este fato deve se por se relacionar ao aumento de doenças crônicas, cujo o avanço da idade é proporcional ao aumento da incidência de diabetes mellitus. Considerações finais: Houve uma percepção de que é importante o acompanhamento farmacoterapêutico dos pacientes com diabetes mellitus, pois muitos desenvolvem outras doenças relacionadas ao mal-uso do fármaco por falta de resposta farmacológica ou apresentam reações adversas relacionadas aos medicamentos administrados.
Caracterização da altura de plantas e índice de clorofila de genótipos de amendoim nas condições de Campo Verde-MT
Authors: Xavier Maxuel Fellipe Nunes , Perozini Alexandre Caetano , Heuert Jair , Rodrigues Maxsuel Antonio , Flores Paulo Ricardo Lima , De Souza Junior Vicente Batista 
Published: October 2021

O presente trabalho teve como objetivo caracterizar as alturas de plantas e o índice de clorofila de genótipos de amendoim nas condições de Campo Verde-MT. O experimento foi realizado no ano agrícola 2019/20 na área experimental do Instituto Federal de Educação, Ciência e Tecnologia de Mato Grosso – Campus São Vicente, Centro de Referência de Campo Verde, localizado no município de Campo Verde – MT. O delineamento experimental utilizado foi em blocos casualizados, com quatro repetições. Os tratamentos foram nove genótipos de amendoim, sendo seis linhagens (1253 OL, 1952 OL, 1900 OL, 1965 OL, 1973 OL e 2133 OL) e três cultivares (BRS 421 OL, BRS 423 OL e BRS 425 OL), ambos desenvolvidos pelo Programa de Melhoramento do Amendoim (PMA) da Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). As parcelas foram constituídas por duas linhas com três metros de comprimento, com intervalo de dois metros entre parcelas. A área útil considerada nas avaliações foram dois metros centrais, totalizando 3,6 m2. O estande médio estabelecido foi 16 plantas.m-1. O experimento foi colhido no dia 20/03/2020 e as características avaliadas foram nove alturas de plantas aos 32, 42, 49, 60, 70, 84, 98, 110 e 122 dias após o plantio (DAP) e o índice de clorofila SPAD aos 40, 70 e 98 DAP. Conclui-se que as médias obtidas nas nove alturas de plantas e nas três avaliações de índice de clorofila, podem servir para caracterizar estes genótipos estudados e agregar em posteriores estudos.
Lateritic Plateaus in the Northern Western Ghats, India; a Review of Bauxite Mining Restoration Practices
Authors: Thorpe C. J. , Watve Aparna 
Published: October 2021

The northern Western Ghats are characterised by plateaus and hilltop carapaces formed from ferricretes rich in aluminium ore. Ferricretes in Western Ghats are home to a high number of endemic species, many with extremely limited distribution. The heterogeneity of microhabitats on ferricretes supports a great diversity of plant and animal communities. With little overburden and a high percentage of recoverable metals they are targeted for mining which leads to removal of all soil, vegetation and microhabitats. Vegetation and faunal diversity of unmined sites from Kolhapur district were studied providing reference data used to discuss restoration efforts on two mined sites in the region. Restoration efforts have faced ecological and legal hurdles. The international literature for the restoration of bauxite mines fails to demonstrate any successful model to return the species assemblage to a pre-mining profile.
Restoration practices fail to adequately replicate microhabitat heterogeneity; often restoring sites to a different ecosystem from the original. The present mining policies do not take cognizance of the special nature of plateau habitats, ecology or the ecosystem functions they provide. We suggest a moratorium on mining of the high level lateritic plateaus in Western Maharashtra is justified until the biodiversity value and ecosystem services of the sites are fully understood and can be weighed against the economic gains from mining.
constructive and metacognitive teaching path at university level on the Principle of Mathematical Induction
Authors: Telloni Agnese Ilaria , Malara Nicolina Antonia 
Published: October 2021

We present the main results about a teaching/learning path for engineering university students devoted to the Principle of Mathematical Induction (PMI). The path, of constructive and metacognitive type, is aimed at fostering an aware and meaningful learning of PMI and it is based on providing students with a range of explorations and conjecturing activities, after which the formulation of the statement of the PMI is devolved to the students themselves, organized in working groups. A specific focus is put on the quantification in the statement of PMI to bring students to a deep understanding and a mature view of PMI as a convincing method of proof. The results show the effectiveness of the metacognitive reflections on each phase of the path for what concerns a) students' handling of structural complexity of the PMI, b) students' conceptualization of quantification as a key element for the reification of the proving process by PMI; c) students' perception of the PMI as a convincing method of proof.
Subject Classification: 97B40, 97C70
Use of space, active and resting behaviour in fattening rabbits (Oryctolagus cuniculus) housed in a combi park system: A case study
Authors: Kimm S , Rauterberg SL , Bill J , Stracke J , Kemper N , Fels M 
Published: October 2021

AbstractIn this case study, a housing system for rabbits (Oryctolagus cuniculus) was developed, complying with the new German Welfare Regulation, and evaluated on-farm with regard to the rabbits’ behaviour during four fattening periods. The housing system was characterised by the large group size of fatteners (maximum 65 animals per group, 12 animals per m2) due to the merging of six former single units for does and their litters, post-weaning. A large elevated platform, a box with a roof (small elevated platform), a tube and gnawing materials were made available per unit. The aim being to assess the suitability of the housing system for rabbits with regard to animal welfare, based on behavioural analyses. Therefore, the use of space by the rabbits (n = 247) was investigated by video analysis (instantaneous scan sampling) during daytime. Additionally, the individual behaviour of 20 focal rabbits in different locations was assessed by continuous sampling. Results showed that rabbits preferred to huddle together in the outer units in the first weeks post-weaning. The highest animal densities were found under and in front of the large and on the small platforms. The large platforms were visited increasingly from the 10th fattening day onwards. Elevated platforms supported resting and comfort behaviours. Non-elevated open-top areas enabled upright positions and locomotor behaviours. Aggression and stereotypic behaviours rarely occurred. We conclude that the housing system supported species-specific behaviour and seemed to cater for the needs of rabbits in terms of welfare. Nevertheless, further investigation is needed to ascertain the effects on animal health and performance.
Dentigerous Cyst Associated with a Misaligned Maxillary First Premolar: A Case Report
Authors: Dib Hassan , Farhat Sarah , Berberi Antoine 
Published: October 2021

Aims: The main goal of the following case report was to shed the light on the importance of thorough clinical, radiological and histological examinations in order to elaborate a final diagnosis of asymptomatic dentigerous cysts detected in unusual locations.
Presentation of Case: A case of dentigerous cyst was identified accidentally in the maxillary left premolar region of an asymptomatic 14-year-old female post an orthodontic consultation. Histological examination of the tissue specimens following enucleation confirmed the diagnosis of a dentigerous cyst.
Discussion: Dentigerous cysts are the second most common odontogenic cysts after radicular cysts. They involve impacted, un-erupted, permanent, supernumerary, odontomas and rarely deciduous teeth. Dentigerous cysts are usually painless but may cause facial swelling and delayed tooth eruption. Extensive maxillary involvement and childhood presentation are rare. Radio-graphic and histological examinations should be done to confirm the diagnosis of a dentigerous cyst.
Conclusion: In our case, we showed the presence of a maxillary premolar dentigerous cyst that was removed by enucleation. The presence of dentigerous cyst is not always associated with a syndrome and its removal is very important to avoid future complications.
A Research Protocol: Comparison of Ultrasound Therapy with Zingiber Cassumunar Roxb based Phonophoresis and Conventional Gel in Patients with Knee Osteoarthritis-Randomized Control Trial
Authors: Joshi Medhavi V. , Phansopkar Pratik A. 
Published: October 2021

Background: Knee Osteoarthritis is considered as the leading cause of the disability in almost all over the world after age of 40. Almost about 54 percent people will end up in knee osteoarthritis in old age. Awareness of non-pharmacological treatment for knee osteoarthritis is more in practice in European as well as in Asian countries. Physical therapy, Ultrasound therapy, Otago exercises etc. are the treatments that are available for conservative management as well as preventive measure of knee Osteoarthritis.
Methodology: Subjects with knee osteoarthritis with grade II to III on Kallgren and Lawrence classification will be included in the study N = 52. Two groups each of 26 will be allocated randomly as group A who will receive ultrasound treatment with Otago exercises control group and group B who will receive ultrasound treatment with zingiber Cassumunar based gel and Otago exercises as experimental group. The Western Ontario and McMaster University Osteoarthritis Index (WOMAC), VAS, star excursion balance test will be performed before and after the treatment after 2 weeks with single blind procedure.
Objective: This research will examine the effect of treatment with Zingiber Cassumunar based gel applied by means of phonophoresis with ultrasound therapy in knee osteoarthritis patients with Randomized control trial.
Nickel‐Catalyzed Selective Synthesis of α‐Alkylated Ketones via Dehydrogenative Cross‐Coupling of Primary and Secondary Alcohols
Authors: Bains Amreen K , Biswas Ayanangshu , Adhikari Debashis 
Published: October 2021

AbstractHerein, we describe an isolable, air‐stable, homogeneous, nickel catalyst that performs dehydrogenative cross‐coupling reaction between secondary and primary alcohols to result α‐alkylated ketone products selectively. The sequence of steps involve in this one‐pot reaction is dehydrogenation of both alcohols, condensation between the ketone and the aldehyde, and hydrogenation of the in situ‐generated α,β‐unsaturated ketone. Preliminary mechanistic investigation hints a radical mechanism following borrowing hydrogen reaction.magnified image
Spatial Structure Regulation: A Rod‐Shaped Viologen Enables Long Lifetime in Aqueous Redox Flow Batteries
Authors: Li Hongbin , Fan Hao , Hu Bo , Hu Linlin , Chang Gang , Song Jiangxuan 
Published: October 2021

AbstractA stable rod‐like sulfonated viologen (R‐Vi) derivative is developed through a spatial‐structure‐adjustment strategy for neutral aqueous organic redox flow batteries (AORFBs). The obtained R‐Vi features four individual methyl groups on the 2,2′,6,6′‐positions of the 4,4′‐bipyridine core ring. The tethered methyls confine the movement of the alkyl chain as well as the sulfonic anion, thus driving the spatial structure from sigmoid to rod shape. The R‐Vi with weak charge attraction and large molecular dimension displays an ultralow membrane permeability that is only 14.7 % of that of typical sigmoid viologen. Moreover, the electron‐donating effect of methyls endows R‐Vi with the lowest redox potential of −0.55 V vs. SHE among one‐electron‐storage viologen‐based AORFBs. The AORFB with the R‐Vi anolyte and a K4Fe(CN)6 catholyte exhibits an energy efficiency up to 87 % and extremely low capacity‐fade rate of 0.007 % per cycle in 3200 continuous cycles.