bluuebunny/crossref_metadata_2025_split huggingface dataset:
De novo variants in thePSMC3proteasome AAA-ATPase subunit gene cause neurodevelopmental disorders associated with type I interferonopathies
Authors: Ebstein Frédéric , Küry Sébastien , Most Victoria , Rosenfelt Cory , Boyer Marie-Pier Scott- , van Woerden Geeske M. , Besnard Thomas , Papendorf Jonas Johannes , Studencka-Turski Maja , Wang Tianyun , Hsieh Tzung-Chien , Golnik Richard , Baldridge Dustin , Forster Cara , de Konink Charlotte , Teurlings Selina M.W. , Vignard Virginie , van Jaarsveld Richard H. , Ades Lesley , Cogné Benjamin , Mignot Cyril , Deb Wallid , Jongmans Marjolijn C.J. , Sessions Cole F. , van den Boogaard Marie-José H. , Wambach Jennifer A. , Wegner Daniel J. , Yang Sandra , Hannig Vickie , Brault Jennifer Ann , Zadeh Neda , Bennetts Bruce , Keren Boris , Gélineau Anne-Claire , Powis Zöe , Towne Meghan , Bachman Kristine , Seeley Andrea , Beck Anita E. , Morrison Jennifer , Westman Rachel , Averill Kelly , Brunet Theresa , Haasters Judith , Carter Melissa T. , Osmond Matthew , Wheeler Patricia G. , Forzano Francesca , Mohammed Shehla , Trakadis Yannis , Accogli Andrea , Harrison Rachel ,   Deciphering Developmental Disorders Study,   Care4Rare Canada Consortium, Rondeau Sophie , Baujat Geneviève , Barcia Giulia , Feichtinger René Günther , Mayr Johannes Adalbert , Preisel Martin , Laumonnier Frédéric , Knaus Alexej , Isidor Bertrand , Krawitz Peter , Völker Uwe , Hammer Elke , Droit Arnaud , Eichler Evan E. , Elgersma Ype , Hildebrand Peter W. , Bolduc François , Krüger Elke , Bézieau Stéphane 
Published: December 2021

AbstractA critical step in preserving protein homeostasis by the ubiquitin-proteasome system (UPS) is the recognition, binding, unfolding, and translocation of protein substrates by AAA-ATPase proteasome subunits for degradation by 26S proteasomes. Here, we identified fourteen differentde novomissense variants in thePSMC3gene encoding the AAA-ATPase proteasome subunit Rpt5 in twenty-two unrelated heterozygous subjects with an autosomal dominant form of neurodevelopmental delay and intellectual disability. Indeed, depletion ofPSMC3impaired reversal learning capabilities in aDrosophilamodel. ThePSMC3variants cause proteasome dysfunction in patient-derived cells by disruption of substrate translocation, proteotoxic stress and proteostatic imbalances, as well as alterations in proteins controlling developmental and innate immune programs. Molecular analysis confirmed the induction of cellular stress responses and dysregulated mitophagy along with an elevated type I interferon (IFN) signature. Our data definePSMC3variants as the genetic cause of proteotoxic stress alerting the innate immune system to mount a type I IFN response and link neurodevelopmental syndromes to interferonopathies.
Moving towards agile: managing Loxon solutions’ hiring strategy, organizational development and agile transformation
Authors: Tóth Adrienn 
Published: December 2021

Subject area
This case focuses on organizational development, leadership and HR management questions.

Study level/applicability
This case is mainly aimed at students specialized in leadership, organizational development and HR, or in MBA and executive education. However, undergraduate students can benefit from it as well and learn about key terms related to organizational development and HR.

Case overview
Loxon Solutions is a Hungarian technology startup founded in 2000 that develops various software solutions for the banking industry to improve processes such as retail and corporate landing, collateral management and monitoring, among others. The company grew significantly since being founded, and from a small IT company it became a significant player in the banking software industry all around the world. However, with rapid extension comes a drastic internal transformation as well: Loxon now employs 252 people, has 5 physical offices in 2 different countries and is trying to balance an effective organizational structure and a friendly startup environment. It is clear that the company needs to adapt its previously informal structure to fit the now middle-sized organization while maintaining the current benefits of their culture. Also, they require stability and maturity which the current team consisting of mostly junior employees and the significant fluctuation cannot provide. Tamas Erni, the CEO and Kristof Farkas, the founder of Loxon are now working on these pressing issues with the company’s HR department to rethink the companyâ€™s organizational structure and policies as well as their hiring and employer branding strategies.

Expected learning outcomes
Students should get familiar with typical organizational structure models, the meaning of Employee Value Proposition and main KPIs related to hiring and employee retention.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 6: HR Management.
Green HRM promotes higher education sustainability: a mediated-moderated analysis
Authors: Abbas Zuhair , Sarwar Shagufta , Rehman Mohsin Abdur , Zámečník Roman , Shoaib Muhammad 
Published: December 2021

PurposeIn the contemporary world, where sustainability at higher education is at the forefront, the ever-changing business ecosystem nurtures a new drift towards economic, environmental and social performance. This study aims to measure the impact of green human resource management (GHRM) practices on sustainability in the higher education of a developing country context through a theoretical aspect of Resource-Based View (RBV).Design/methodology/approachThis study adopted a quantitative approach to propose and test a model based on predictors of sustainability. The survey approach received 190 responses from employees (faculty and non-faculty members) working as a full-time in the 40 higher education institutions (HEIs) of Pakistan. The structural and measurement model was calculated using SmartPLS.FindingsThe results show that “green training and development” (GTD) and “top management commitment towards greening workforce (TMCGW)” have a positive relationship with sustainability while green recruitment and selection (GRS) was not supported by sustainability. The mediating effect of TMCGW plays a crucial role between GTD and sustainability. Also, this study contributes through the moderating interaction effect of Gender between GTD and sustainability. Overall the GHRM practices promote employee green behavior and sustainability.Originality/valueThe proposed research model in the current study is a substantial gap in the literature and exploring this connection requires new theoretical frameworks. To bridge this literature gap, this study examined the role of GHRM on sustainability at micro-level (employee perspective) through a theoretical aspect of RBV in the developing country higher education context of Pakistan. Importantly, this study enhances the understanding of the emerging global wave of green mobility and highlights the impact of GHRM practices on sustainability through perception of academic professionals.
The master narrative of older employees in changing workplaces
Authors: Niemi Tuukka , Komp-Leukkunen Kathrin 
Published: December 2021

PurposeInterest in older employees increases in times of population ageing. Previous research exploring the situation has underlined older employees' struggle with workplace changes. However, it has not explored their master narrative – the socially shared narrative about older employees that steers behaviour. This study explores this narrative and its differences across changing workplaces. It draws on Lyotard's suggestion that master narratives disintegrate in post-modern societies.Design/methodology/approachThis study conducts focus groups among older Finnish employees of an airline, postal service and social care. These groups experienced different kinds of workplace changes, namely mass layoffs, digitalisation and restructuring. The focus groups highlight the individuals' shared narratives, thereby pinpointing the master narrative.FindingsThe master narrative describes how simultaneous changes at the workplace and in their health lead older employees to look for ways to exit their jobs. This narrative is largely stable across workplaces, showing no disintegration but some variation.Originality/valueThis is the first study on the master narrative of older employees and its disintegration. To the authors’ knowledge, it is also the first study to use focus groups to explore a master narrative.
Environmental efficiency of Xiangjiang River in China: a data envelopment analysis cross-efficiency approach
Authors: An Qingxian , Cheng Zhaokun , Shi Shasha , Li Fenfen 
Published: December 2021

PurposeEnvironmental performance becomes a key issue for the sustainable development. Recently, incremental information technology is adopted to collect environmental data and improve environmental performance. Previous environmental efficiency measures mainly focus on individual decision-making units (DMUs). Benefited from the information technology, this paper develops a new environmental efficiency measure to explore the implicit alliances among DMUs and applies it to Xiangjiang River.Design/methodology/approachThis study formulates a new data envelopment analysis (DEA) environmental cross-efficiency measure that considers DMUs' alliances. Each DMUs' alliance is formulated by the DMUs who are supervised by the same manager. In cross-efficiency evaluation context, this paper adopts DMUs' alliances rather than individual DMUs to derive the environmental cross-efficiency measure considering undesirable outputs. Furthermore, the Tobit regression is conducted to analyze the influence of exogenous factors about the environmental cross-efficiency.FindingsThe findings show that (1) Chenzhou performs the best while Xiangtan performed the worst along Xiangjiang River. (2) The environmental efficiency of cities in Xiangjiang River is generally low. Increasing public budgetary expenditure can improve environmental efficiency of cities. (3) The larger the alliance size, the higher environmental efficiency. (4) The income level is negatively correlated with environmental efficiency, indicating that the economy is at the expense of the environment in Xiangjiang River.Originality/valueThis paper contributes to developing a new environmental DEA cross-efficiency measure considering DMUs' alliance, and combining DEA cross-efficiency and Tobit regression in environmental performance measurement of Xiangjiang River. This paper examines the exogenous factors that have influences on environmental efficiency of Xiangjiang River and derive policy implications to improve the sustainable operation.
Investor sentiment and liquidity in emerging stock markets
Authors: Messaoud Dorra , Ben Amar Anis , Boujelbene Younes 
Published: December 2021

PurposeBehavioral finance and market microstructure studies suggest that the investor sentiment and liquidity are related. This paper aims to examine the aggregate sentiment–liquidity relationship in emerging markets (EMs) for both the sample period and crisis period. Then, it verifies this relationship, using the asymmetric sentiment.Design/methodology/approachThis study uses a sample consisting of stocks listed on the SSE Shanghai composite index (348 stocks), the JKSE (118 stocks), the IPC (14 stocks), the RTS (12 stocks), the WSE (106 stocks) and FTSE/JSE Africa (76 stocks). This is for the period ranging from February, 2002 until March, 2021 (230 monthly observations). We use the panel data and apply generalized method-of-moments (GMM) of dynamic panel estimators.FindingsThe empirical analysis shows the following results: first, it demonstrates a significant relationship between the aggregate investor sentiment and the stock market liquidity for the sample period and crisis one. Second, referring to the asymmetric sentiment, we have empirically given proof that the market is significantly more liquid in times of the optimistic sentiment than it is in times of the pessimistic sentiment. Third, using panel causality tests, we document a unidirectional causality between the investor sentiment and liquidity in a direct manner through the noise traders and the irrational market makers and also a bidirectional causality in an indirect channel.Practical implicationsThe results reported in this paper have implications for regulators and investors in EMs. Firstly, the study informs the regulators that the increases and decreases in the stock market liquidity are related to the investor sentiment, not financial shocks. We empirically evince that the traded value is higher in the crisis. Secondly, we inform insider traders and rational market makers that the persistence of increases in the trading activity in both quiet and turbulent times is associated with investor participants such as noise traders and irrational market makers.Originality/valueThe originality of this work lies in employing the asymmetric sentiment (optimistic/pessimistic) in order to denote the sentiment–liquidity relationship in EMs for the sample period and the 2007–2008 subprime crisis.
The mechanisms linking the finance-growth relationship in view of the financial crisis: an empirical investigation of the EU countries
Authors: Asteriou Dimitrios , Spanos Konstantinos 
Published: December 2021

PurposeThe paper aims to explore the mechanisms linking the impact of financial development on economic growth and focuses on the long-term post-global financial crisis.Design/methodology/approachThe study employs panel data for twenty-five European Union countries over the period 1995–2017. Principal Component Analysis is employed to produce two aggregate indices, namely financial banking sector development and stock market sector development. The empirical analysis is based on estimates through the autoregressive distributed lag (ARDL) method.FindingsThe results suggest that the outbreak of the crisis has led to a disruption of the positive finance-growth relationship, and the banking sector dominates in this adverse effect. The foreknowledge of the current study is that the linking mechanisms of the negative impact of financial development on economic growth, ten years after the global financial crisis, are household debt, private debt, and non-performing loans for the banking sector, while for the equity market this is the case through savings. Interestingly, the results reveal that unemployment increase excessively the borrowers' debt level and then the non-performing loans.Research limitations/implicationsAn implication is that the increase of credit supply and any monetary expansion along with lack of regulatory control and monitoring can lead banks to a higher risk exposure through household and private debt as well as non-performing loans. Besides, the higher levels of unemployment rates call attention for the trade-off between prudential regulation on the supply of loans and economic activity, since higher unemployment affect the non-performing loans and, as a consequence discourage the demand, increase precautionary savings, and cancel or postpone investment decisions, thus, affecting the equity market.Originality/valueThe paper provides useful insights to economists and policymakers who are interested in understanding the weakness of banking and stock market sectors to promote economic growth for a long time after the global financial crisis.
COVID-19 and self-initiated expatriate health workers: Spanish nurses in Germany
Authors: Rosa González Juan Miguel , Barker Michelle , Shah Dhara 
Published: December 2021

PurposeGiven that the incidence of coronavirus disease 2019 (COVID-19) varies greatly between countries, it becomes relevant to explore self-initiated expatriate (SIE) health workers' perceptions of home vs host country safety during a global pandemic. Thus, the paper aims to study the effects of COVID-19 on the expatriation experience of Spanish SIE nurses in Germany, focussing on perceptions of home and host country safety as push/pull forces on their intentions to repatriate or stay.Design/methodology/approachSemi-structured interviews (n = 10) were conducted with Spanish SIE nurses in Germany between April/June 2020 followed by instant messaging interactions with the same participants in October/November 2020. Data analysis was assisted by NVivo software.FindingsOverloaded by information from social networks about the impact of COVID-19 in Spain compared with the situation in Germany, Spanish SIE nurses had exacerbated feelings of stress, and some reported having experienced guilt for not being in their home country. Nevertheless, the contrasting impact and management of the crisis and its relative effect on health workers and the larger society in Spain and Germany reinforced the nurses' intention to stay in Germany.Research limitations/implicationsThe research offers insights to organisations and public authorities involved with providing support to SIEs during crises, highlighting the implications of SIEs' social networks and dual allegiance to home and host countries during a global health emergency.Originality/valueThe study contributes to the growing literature on SIEs, whilst adding to the research on expatriates' well-being and safety during crises.
Appropriating integrated performance management tools in healthcare: a sociomaterial work story
Authors: Côté-Boileau Élizabeth , Breton Mylaine , Rouleau Linda , Denis Jean-Louis 
Published: December 2021

PurposeThe purpose of this paper is to explore the appropriation of control rooms based on value-based integrated performance management tools implemented in all publicly funded health organizations in Quebec (Canada) as a form of legitimate sociomaterial work.Design/methodology/approachMulti-site organizational ethnographic case studies in two Integrated health and social services centers, with narrative process analysis of triangulated qualitative data collected through non-participant observation (163 h), individual semi-structured interviews (N = 34), and document review (N = 143).FindingsThree types of legitimate sociomaterial work are accomplished when actors appropriate control rooms: 1) reformulating performance management work; 2) disrupting accountability work and; 3) effecting value-based integrated performance management. Each actor (tools, institutions and people) follows recurrent institutional work-paths: tools consistently engage in disruptive work; institutions consistently engage in maintaining work, and people consistently engage in creation work. The study reveals the potential of performance management tools as “effective integrators” of the technological, managerial, policy and delivery levels of data-driven health system performance and improvement.Practical implicationsThis paper draws on theoretically informed empirical insights to develop actionable knowledge around how to better design, implement and adapt tool-driven health system change: 1) Packaging the three agents of data-driven system change in health care: tools, institutions, people; 2) Redefining the search for performance in health care in the context of value creation, and; 3) Strengthening clinical and managerial relevance in health performance management practice.Originality/valueThe authors aim to stimulate new and original scholarship around the under-theorized concept of sociomaterial work, challenging theoretical, ontological and practical conceptions of work in healthcare organizations and beyond.
Transdisciplinarity and epistemic communities: Knowledge decolonisation through university extension programmes
Authors: Rodríguez Denisse 
Published: December 2021

AbstractIn Latin America, a legacy of colonisation is the pervasiveness of a Eurocentric approach to knowledge. This geopolitics of knowledge entails the prioritisation of “rational” scientific knowledge over the mosaic epistemology that characterises a population born from high mestizaje (cultural and ethnic heterogeneity). Alternatively, universities could advance global cognitive justice by means of knowledge decolonisation. This article explores one way to advance that project. Based on contributions from Luso‐Hispanic scholars, I propose university extension programmes be reformulated to include epistemic communities as ecologies of knowledges. Theoretical insights are contrasted with an Ecuadorian experience, where a centre originally created to disseminate georeferenced socioeconomic and ecological indicators has evolved into a knowledge community with potential to promote plural dialogue of knowledges and influence decision making.
Protective role of ergothioneine isolated from Pleurotus ostreatus against dextran sulfate sodium‐induced ulcerative colitis in rat model
Authors: Pang Lan , Wang Ting , Liao Qian , Cheng Yanfen , Wang Di , Li Jingjing , Fu Chaomei , Zhang Chen , Zhang Jinming 
Published: December 2021

AbstractThe well‐acknowledged sulfur‐containing amino acid ergothioneine (EGT), which is usually perceived to be produced from fungi, cyanobacteria, and mushrooms, has been increasingly demonstrated as a diet‐derived antioxidant with therapeutic potential. However, little is known regarding the therapeutic benefit against ulcerative colitis of EGT. Meanwhile, few studies have reported whether EGT could be produced by Pleurotus ostreatus, which is the second most cultivated edible mushroom worldwide, with ideal economic and ecological values and medicinal properties. In the current study, EGT was primarily extracted and isolated from P. ostreatus by water extraction and alcohol precipitation. Then, the Sephadex G‐10 gel permeation chromatography and preparative high‐performance liquid chromatography were employed in order to purify and collect EGT. Based on nuclear magnetic resonance spectrum characterization, the content of EGT extracted from P. ostreatus is 1.916 mg/g (the weight of EGT is the same as that of dry P. ostreatus). Finally, both the antioxidant activity in vitro and potential effects of EGT on dextran sulfate sodium‐induced ulcerative colitis in rats were investigated. The results showed that the collected EGT exhibited strong antioxidant activity with a concentration‐dependent manner in 1,1‐diphenyl‐2‐picrylhydrazyl and 2,2′‐azinobis (3‐ethylbenzoline‐6‐sulphonic acid) assays. The oral administration of EGT can significantly alleviate colon length shortening and colonic pathological damage, mediated by downregulating the expression of pro‐inflammatory factors and inhibiting TLR4/MyD88/NF‐κB signaling pathway. Therefore, this study demonstrated that EGT from P. ostreatus would be an excellent dietary compound to ameliorate ulcerative colitis.Practical ApplicationIn order to develop Pleurotus ostreatus as a functional food and related products for the prevention and treatment of ulcerative colitis, the separation and purification technology of ergothioneine (EGT) from P. ostreatus was studied, which not only provided a new and broader source for the acquisition and development of EGT, but also provided a basis for the development of EGT as a drug against UC.