bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation Between Circulating Tumor Cell DNA Genomic Alterations and Mesenchymal CTCs or CTC-Associated White Blood Cell Clusters in Hepatocellular Carcinoma
Authors: Wang Chunming , Luo Qiong , Huang Wenbin , Zhang Cheng , Liao Hangyu , Chen Kunling , Pan MingXin 
Published: June 2021

PurposeLiquid biopsy is attracting attention as a method of real-time monitoring of patients with tumors. It can be used to understand the temporal and spatial heterogeneity of tumors and has good clinical application prospects. We explored a new type of circulating tumor cell (CTC) enrichment technology combined with next-generation sequencing (NGS) to analyze the correlation between genomic alterations in circulating tumor cells of hepatocellular carcinoma and the counts of mesenchymal CTCs and CTC-associated white blood cell (CTC-WBC) clusters.MethodsWe collected peripheral blood samples from 29 patients with hepatocellular carcinoma from January 2016 to December 2019. We then used the CanPatrol™ system to capture and analyze mesenchymal CTCs and CTC-WBC clusters for all the patients. A customized Illumina panel was used for DNA sequencing and the Mann–Whitney U test was used to test the correlation between mesenchymal CTCs, CTC-WBC cluster counts, and specific genomic changes.ResultsAt least one somatic hotspot mutation was detected in each of the 29 sequenced patients. A total of 42 somatic hot spot mutations were detected in tumor tissue DNA, and 39 mutations were detected in CTC-DNA, all of which included common changes in PTEN, MET, EGFR, RET, and FGFR3. The number of mesenchymal CTCs was positively correlated with the somatic genomic alterations in the PTEN and MET genes (PTEN, P = 0.021; MET, P  = 0.008, Mann–Whitney U test) and negatively correlated with the somatic genomic alterations in the EGFR gene (P = 0.006, Mann–Whitney U test). The number of CTC-WBC clusters was positively correlated with the somatic genomic alterations in RET genes (P  = 0.01, Mann–Whitney U test) and negatively correlated with the somatic genomic alterations in FGFR3 (P = 0.039, Mann–Whitney U test).ConclusionsWe report a novel method of a CTC enrichment platform combined with NGS technology to analyze genetic variation, which further demonstrates the potential clinical application of this method for spatiotemporal heterogeneity monitoring of hepatocellular carcinoma. We found that the number of peripheral blood mesenchymal CTCs and CTC-WBC clusters in patients with hepatocellular carcinoma was related to a specific genome profile.
Risks and Protective Factors Associated With Mental Health Symptoms During COVID-19 Home Confinement in Italian Children and Adolescents: The #Understandingkids Study
Authors: Oliva Salvatore , Russo Giusy , Gili Renata , Russo Luigi , Di Mauro Antonio , Spagnoli Alessandra , Alunni Fegatelli Danilo , Romani Maria , Costa Anna , Veraldi Silvio , Manti Filippo 
Published: June 2021

Objective: To identify risk and protective factors for mental health symptoms associated with lifestyle changes caused by home confinement in pediatric subjects and in children and adolescents with a neuropsychiatric disorder.Study design: This was a prospective, cross-sectional study conducted from May 10 to May 31, 2020. Two online anonymous surveys were developed: population-based and clinical-based (children with neuropsychiatric disorders). Outcomes included emotional and behavioral symptoms, as assessed by psychometric scales (BPSC, PPSC, PSC, CES-DC and SCARED, respectively), and lifestyle changes during home confinement (i.e., physical activity, screen time, home schooling, reading).Results: The sample included 9,688 pediatric subjects, and 289 children and adolescents with a neuropsychiatric disorder. The presence of siblings was a protective factor in all ages. In pre- and school children: male sex, a diagnosis of autism, residency in highly affected areas, high parental educational level or job loss, and screen time (&gt;2 h/day) were risk factors. Physical activity, home-schooling, reading, talking with other people were protective factors. Residency in highly affected areas, a diagnosis of mood disorder, parental job loss, and screen time, were associated with a worsening of the depressive symptoms, whereas physical activity, talking with other people, playing with parents were protective activities. Screen time was also a risk factor for anxiety symptoms, while physical activity, reading and talking with other people were protective factors.Conclusions: This study identified risk and protective factors for mental health symptoms associated with lifestyle changes caused by COVID-19 home confinement to promote mental well-being in pediatrics during pandemic times.
Abnormal Orientation of the Superior Mesenteric Vessels Detected in Asymptomatic Infants: What Is Its Destiny?
Authors: Son Joonhyuk , Lee Sanghoon , Kim Wontae , Jung Soo-Min , Jeon Tae Yeon , Yoo So-Young , Kim Ji Hye , Seo Jeong-Meen 
Published: June 2021

Background: Ultrasonography (USG) has been described as an alternative diagnostic tool for malrotation that evaluates the orientation of the superior mesenteric vessels. However, literature concerning the management of patients who do not have abdominal symptoms is limited. We aimed to review the clinical course of infants showing abnormal orientation of the superior mesenteric vessels on USG who were asymptomatic at the time of diagnosis.Methods: Seventy asymptomatic infants with abnormal orientation of the superior mesenteric vessels in a single center between 2014 and 2018 were retrospectively analyzed.Results: The 70 patients, 21 underwent upper gastrointestinal series (UGIS) and 11 underwent abdominal surgery for other surgical conditions. Among the 32 (45.7%) patients who underwent UGIS or abdominal surgery, 11 were proven to have malrotation. Of the 38 (54.3%) patients who did not undergo UGIS or abdominal surgery, six patients were too unstable to undergo UGIS, five died due to cardiac complications, and the remaining patient developed midgut volvulus and died 3 days after emergency surgery. The remaining 32 patients who did not undergo UGIS or abdominal surgery were discharged without additional tests, and all were asymptomatic until their last follow-up. In the multivariate analysis, history of heart surgery and the presence of more than three anomalies were significantly associated with malrotation.Conclusion: A significant number of malrotation were diagnosed in asymptomatic infants with abnormal orientation of the superior mesenteric vessels on USG. Infants with major cardiac or multiple anomalies need special attention and should undergo UGIS in a promptly manner to confirm malrotation.
Efficacy of CytoSorb in a Pediatric Case of Severe Multisystem Infammatory Syndrome (MIS-C): A Clinical Case Report
Authors: Bottari Gabriella , Confalone Valerio , Cotugno Nicola , Guzzo Isabella , Perdichizzi Salvatore , Manno Emma C. , Stoppa Francesca , Cecchetti Corrado 
Published: June 2021

Background:Multisystem inflammatory syndrome in children (MIS-C) has emerged during the COVID-19 pandemic as a new SARS-CoV-2-related entity, potentially responsible for a life-threatening clinical condition associated with myocardial dysfunction and refractory shock.Case:We describe for the first time in a 14-year-old girl with severe MIS-C the potential benefit of an adjuvant therapy based on CytoSorb hemoperfusion and continuous renal replacement therapy with immunomodulatory drugs.Conclusions:We show in our case that, from the start of extracorporeal blood purification, there was a rapid and progressive restoration in cardiac function and hemodynamic parameters in association with a reduction in the most important inflammatory biomarkers (interleukin 6, interleukin 10, C-reactive protein, ferritin, and D-dimers). Additionally, for the first time, we were able to show with analysis of the sublingual microcirculation a delayed improvement in most of the important microcirculation parameters in this clinical case of MIS-C.
A Cross-Sectional Study on Mental Health Problems of Medical and Nonmedical Students in Shandong During the COVID-19 Epidemic Recovery Period
Authors: Zheng Xiaolei , Guo Yuji , Yang Hui , Luo Liyan , Ya Bailiu , Xu Hong , Xue Zhiwei , Li Qing , Shi Jiale , Bi Jianzhong , Ma Wen , Wang Ping 
Published: June 2021

Background: The coronavirus disease 2019 (COVID-19) pandemic has resulted in a plethora of psychological problems worldwide since its onset in December 2019. In the upheaval period, compared with medical college students, nonmedical students' psychological state deserves additional concern due to their lack of medical knowledge. Although the epidemic in China has been largely controlled for several months, the mental health problems resulting from the COVID-19 epidemic persist to this day. In this study, we assessed the mental health problems and associated risk factors experienced by nonmedical vs. medical college students in universities of Shandong Province during the COVID-19 epidemic recovery period.Methods: An online survey was conducted over the period from 17 to 19 December 2020. A total of 954 Chinese college students (486 nonmedical and 468 medical students) from three universities of Shandong Province participated in the survey. Mental health variables were assessed with use of Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Insomnia Severity Index (ISI).Results: Compared with medical students, nonmedical college students had higher prevalence rates of depression (53.9 vs. 46.4%; p = 0.020) and insomnia (28.0 vs. 22.4%, p = 0.049), as well as higher total scores on the PHQ-9 (p = 0.03) and ISI (p &lt; 0.01). Among nonmedical college students, being female and native of non-Shandong were risk factors for anxiety and depression (p &lt; 0.01), while only native of non-Shandong for insomnia (p &lt; 0.01). Among medical students, age (p &lt; 0.01) and living in rural areas (p = 0.04) were risk factors for depression, while only age (p &lt; 0.05) was a risk factor for anxiety and insomnia.Conclusion: Nonmedical college students in the universities of Shandong Province had more mental health problems and more risk factors for developing them during the COVID-19 epidemic recovery period than medical students. These nonmedical students require additional attention and recovery programs to alleviate the increased incidence of psychological problems related to COVID-19.
Rota dos Nativos sob a perspectiva do turismo sustentável: estudo em comunidades de Nísia Floresta (RN)
Authors: Moreira Sueli Aparecida , Silva Ingrid Rosalina da , Dutra Camila Kayssa Targino , Cunha Silvânia , Santos Gilberto Correia dos , Sobrinho Bruno Ferreira Nunes , Bridi Guilherme 
Published: June 2021

Rota dos Nativos é um roteiro turístico localizado no Município de Nísia Floresta, litoral sul do Rio Grande do Norte, que abrange sete lagoas. Portanto, o objetivo do estudo envolveu caracterizar a rota das lagoas em Nísia Floresta para analisar o impacto das práticas excursionistas sobre os recursos hídricos. A pesquisa é de abordagem qualitativa através de observação participante no contexto das lagoas. Adicionalmente, empregou-se roteiro temático em entrevistas com representantes locais. Constatou-se que o turismo sustentável pode ser adotado, considerando que as lagoas precisam ser conservadas, priorizando as comunidades. O turismo sustentável combinado às ações de Educação Ambiental poderá trazer benefícios para o desenvolvimento regional.
Penerapan Laporan Keuangan Masjid Jami’ Al-Hidayah Pondok Bambu sesuai PSAK 45
Authors: Purwanti Ari , Riyanto Adi 
Published: June 2021

Abstrak
Pengabdian masyarakat ini diselenggarakan pada Masjid Jami’ Al-Hidayah yang berlokasi di Jl. Pondok Bambu Asri Raya No.10 RW.09 Kelurahan Pondok Bambu, Kecamatan Duren Sawit, Jakarta Timur. Penentuan masjid ini berasal dari permintaan dari pengawas masjid untuk membantu mencarikan cara bagaimana pelaporan keuangan yang efektif dan memiliki standar. Metode pelaksanaan pengabdian masyarakat ini diselenggarakan dengan serangkaian metode dalam 3 tahap, yaitu tahap pengumpulan data, tahap penyusunan dan implementasi teknis, dan tahap evaluasi. Pada tahap 1 dilakukan beberapa metode pengumpulan data, di antaranya: wawancara, observasi, dan pendokumentasian. Tahap 2 merupakan tahap penyusunan langkah-langkah pelaporan dan implementasi. Setelah memperoleh data, mulailah disusun langkah-langkah pelaporan keuangan berdasarkan PSAK 45 dan kemudian dibuat format excel link-nya sesuai dengan bagan alir kegiatan keuangan masjid. Setelah itu dicobakan dan dilakukan pendampingan terhadap pengurus yang akan menggunakan sistem akuntansi. Tahap 3 adalah tahap evaluasi yang bertujuan untuk mengetahui tingkat keberhasilan penerapan dan kenyamanan pemakai sistem akuntansi.
Kata Kunci: Masjid; Pelaporan Keuangan; Excel Accounting.

Abstract
This community service was held at the Jami 'Al-Hidayah Mosque, located on Jl. Pondok Bambu Asri Raya No.10 RW.09 Pondok Bambu Village, Duren Sawit District, East Jakarta. The determination of this mosque came from a request from the mosque supervisor to help find a way of how to provide effective and standardized financial reporting. This method of implementing community service is carried out by a series of methods in 3 stages, namely the data collection stage, the technical preparation and implementation stage, and the evaluation stage. In stage 1, several data collection methods were carried out, including: interviews, observation, and documentation. Stage 2 is the stage of preparing the reporting and implementation steps. After obtaining the data, begin to compile the steps for financial reporting based on PSAK 45 and then create an excel link format according to the flow chart of mosque financial activities. After that, it is tested and provided assistance to the management who will use the accounting system. Stage 3 is the evaluation stage which aims to determine the level of success of the application and the comfort of the accounting system users.
Keywords: Mosque; Finance report; Excel Accounting.
Biologia e pesca do camarão sete-barbas (Xiphopenaeus kroyeri, Heller 1862) no Balneário Barra do Sul, SC
Authors: Rodrigues Luiz Fernando , Boos Harry , Branco Joaquim Olinto 
Published: June 2021

A produção desembarcada do camarão sete-barbas no Brasil mostrou uma redução considerável nos últimos anos quando comparada a produção anteriormente descrita. Na avaliação do risco de extinção, a espécie foi categorizada com “Dados Insuficientes - DD”, neste sentido, este trabalho preenche algumas das lacunas no conhecimento do camarão sete-barbas em uma tradicional área de pesca do Estado de Santa Catarina. Foram realizadas, entre fevereiro de 1993 a novembro de 1994, 41 amostragens sendo observados 14.873 indivíduos. As fêmeas predominaram na maioria dos meses, com diferença significativa na proporção de machos e fêmeas. Nos machos o comprimento do cefalotórax variou entre 6 e 28 mm. Já as fêmeas, independente do estádio de maturação gonadal, apresentaram comprimento do cefalotórax entre 6 e 35 mm. O crescimento do camarão sete-barbas, foi descrito pelas equações para os machos Lc = 26,9(1-e-0,7797t) e para as fêmeas Lc= 37,6(1-e-0,6328t). Já o crescimento em peso foi descrito pelas seguintes expressões: para machos Wt=11,7(1-e-0,7797t)2,7905 e para as fêmeas Wt=25,0(1-e-0,6328t)2,5621. Durante o período do estudo observou-se a ocorrência de fêmeas em todos os estádios gonadais. Os picos de desova ficaram evidenciados no período primavera/verão, enquanto que no outono/inverno observaram-se as maiores concentrações de fêmeas imaturas. O tamanho da primeira maturação das fêmeas foi estimado em 19,5 mm de comprimento do cefalotórax. Foi verificado que a atividade pesqueira está capturando na maior parte do ano fêmeas que não atingiram a maturidade sexual, situação que compromete a sustentabilidade da atividade.
The High-energy Spectrum of the Nearby Planet-hosting Inactive Mid-M Dwarf LHS 3844
Authors: Diamond-Lowe Hannah , Youngblood Allison , Charbonneau David , King George , Teal D. J. , Bastelberger Sandra , Corrales Lia , Kempton Eliza M.-R. 
Published: June 2021

Abstract
To fully characterize the atmospheres, or lack thereof, of terrestrial exoplanets, we must include the high-energy environments provided by their host stars. The nearby mid-M dwarf LHS 3844 hosts a terrestrial world that lacks a substantial atmosphere. We present a time-series UV spectrum of LHS 3844 from 1131 to 3215 Å captured by HST/COS. We detect one flare in the FUV that has an absolute energy of 8.96 ± 0.77 × 1028 erg and an equivalent duration of 355 ± 31 s. We extract the flare and quiescent UV spectra separately. For each spectrum, we estimate the Lyα flux using correlations between UV line strengths. We use Swift-XRT to place an upper limit on the soft X-ray flux and construct a differential emission model to estimate flux that is obscured by the interstellar medium. We compare the differential emission model flux estimates in the XUV to other methods that rely on scaling from the Lyα, Si iv, and N v lines in the UV. The XUV, FUV, and NUV flux of LHS 3844 relative to its bolometric luminosity is log10(L
band/L
Bol) =−3.65, −4.16, and −4.48, respectively, for the quiescent state. These values agree with trends in high-energy flux as a function of stellar effective temperature found by the MUSCLES survey for a sample of early-M dwarfs. Many of the most spectroscopically accessible terrestrial exoplanets orbit inactive mid-to-late M dwarfs like LHS 3844. Measurements of M dwarf high-energy spectra are preferable for exoplanet characterization but are not always possible. The spectrum of LHS 3844 is a useful proxy for the current radiation environment for these worlds.
The Influence of the Secular Perturbation of an Intermediate-mass Companion. II. Ejection of Hypervelocity Stars from the Galactic Center
Authors: Zheng 郑 Xiaochen 晓晨 , Lin 林 Douglas N. C. 潮 , Mao 毛 Shude 淑德 
Published: June 2021

Abstract
There is a population of stars with velocities in excess of 500 km s−1 relative to the Galactic center. Many, perhaps most, of these hypervelocity stars (HVSs) are B stars similar to the disk and S stars in a nuclear cluster around a supermassive black hole (SMBH) near Sgr A⋆. In Paper I of this series, we showed that the eccentricity of the stars emerged from a hypothetical disk around the SMBH that can be rapidly excited by the secular perturbation of its intermediate-mass companion (IMC), and we suggested IRS 13E as a potential candidate for the IMC. Here we show that this process leads to an influx of stars on parabolic orbits to the proximity of Sgr A⋆ on a secular timescale of a few megayears. This timescale is much shorter than the diffusion timescale into the lost cone through either the classical or the resonant relaxation. Precession of the highly eccentric stars’ longitude of periastron, relative to that of the IMC, brings them to its proximity within a few megayears. The IMC’s gravitational perturbation scatters a fraction of the stars from nearly parabolic to hyperbolic orbits with respect to the SMBH. Their follow-up close encounters with the SMBH induce them to escape with hypervelocity. This scenario is a variant of the hypothesis proposed by Hills based on the anticipated breakup of some progenitor binary stars in the proximity of the SMBH, and its main objective is to account for the limited life span of the known HVSs. We generalize our previous numerical simulations of this process with a much wider range of orbital configurations. We demonstrate the robustness and evaluate the efficiency of this channel of HVS formation. From these numerical simulations, we infer observable kinematic properties for the HVSs.
Parameterizing the Outflow from a Central Black Hole in Dwarf Spheroidal Galaxies: A 3D Hydrodynamic Simulation
Authors: Lanfranchi Gustavo A. , Hazenfratz Roberto , Caproni Anderson , Silk Joseph 
Published: June 2021

Abstract
Large galaxies harbor massive central black holes and their feedback exerts a substantial impact on their evolution. Recently, observations have suggested that dwarf galaxies might host black holes in their centers, but with lower masses (intermediate-mass black holes—IMBHs). The impact of IMBHs on the evolution of dwarf spheroidal galaxies (dSphs), however, has so far not been properly analyzed. In this work, we investigate the effects of an outflow from an IMBH on gas dynamics in dSphs by means of noncosmological, three-dimensional hydrodynamic simulations, letting the galactic gas distribution evolve over 3 Gyr under the influence of the IMBH’s outflow and supernova feedback. All simulations have a numerical resolution of 20.0 pc cell−1. Two scenarios are considered to infer differences in the propagation of the outflow, one with a homogeneous interstellar medium (ISM) and another one with inhomogeneities caused by supernova feedback. A minimal initial speed and a minimal initial density are required for the outflow to propagate, with the values depending on the conditions of the medium. In an unperturbed medium, the outflow propagates freely in both directions with the same velocity (lower than the initial one), removing a small fraction of gas from the galaxy (the exact fraction depends on the initial physical conditions of the outflow). However, in an inhomogeneous ISM, the impact of the outflow is substantially reduced, and its contribution to the removal of gas from the galaxy is almost negligible.
L’Homme qui plantait des arbres , de Jean Giono : une adaptation et des usages scolaires singuliers
Authors: Richard-Principalli Patricia 
Published: June 2021

L’Homme qui plantait des arbres , de Jean Giono, figure continument dans la liste ministérielle de référence en littérature pour le cycle 3, depuis 2002 jusqu’à aujourd’hui, sous la forme d’une édition jeunesse recommandée, la collection « Folio Cadet », illustrée par Willi Glasauer. L’étude décrit ainsi un processus « juvénilisation » en deux étapes : d’abord par la publication en édition jeunesse, ensuite par l’introduction à l’école de cette édition via la préconisation ministérielle. Elle interroge cette adaptation et ses effets, en envisageant les caractéristiques du texte originel liées au contexte de son écriture. Elle montre également que l’adaptation, pour la collection de Gallimard, d’un texte initialement destiné à un lectorat adulte n’est ni réécrite, ni abrégée, ni traduite, révélant ainsi le rôle de cette adaptation dans l’usage que l’école fait du texte. Les zones d’ambigüité dont jouent l’auteur comme le texte, mais aussi l’édition jeunesse, expliquent à nos yeux le succès de cette œuvre, régulièrement étudiée à l’école primaire, dans un contexte d’urgence environnementale qui l’actualise.
Géographie d’une surproduction. Tribulations d’invendus textiles dans le corridor Abidjan-Lagos
Authors: Le Borgne Nicolas 
Published: June 2021

En Afrique de l’Ouest, des stocks de textiles neufs invendus sont quotidiennement écoulés. Provenant d’Asie et d’Europe, ces marchandises trouvent une place toute particulière sur des marchés : contrefaçons, fripes et vêtements dits « traditionnels » y sont commercialisés. Cet article étudie le développement d’une filière de (re)commercialisation des rebuts industriels textiles. Cet objet qu’est l’invendu invite à explorer les liens entre Nord et Sud mais aussi entre les différents pays du Sud, entre les périphéries de la mondialisation qui révèlent des logiques de surproduction et de leur gestion. Ce texte propose de suivre certaines marchandises et, avec elles, des personnes, des modes de production, des idées qui circulent le long du corridor urbain ouest-africain entre Abidjan et Lagos. Appréhender la circulation des invendus permet d’illustrer la mondialisation par le bas.