bluuebunny/crossref_metadata_2025_split huggingface dataset:
International study to develop the WOUND‐Q patient‐reported outcome measure for all types of chronic wounds
Authors: Klassen Anne F. , van Haren Emiel L. W. G. , van Alphen Tert C. , Cano Stefan , Cross Karen M. , van Dishoeck Anne‐Margreet , Fan Kenneth L. , Michael Hoogbergen Maarten , Orgill Dennis , Poulsen Lotte , Ahm Sørensen Jens , Squitieri Lee , Tsangaris Elena , Vasilic Dalibor , Pusic Andrea L. 
Published: March 2021

AbstractPatient‐reported outcome measures (PROMs) for chronic wounds mainly focus on specific types of wounds. Our team developed the WOUND‐Q for use with all types of wounds in any anatomic location. We conducted 60 concept elicitation interviews with patients in Canada, Denmark, the Netherlands, and the United States. Analysis identified concepts of interest to patients and scales were formed and refined through cognitive interviews with 20 patients and input from 26 wound care experts. Scales were translated into Danish and Dutch. An international field‐test study collected data from 881 patients (1020 assessments) with chronic wounds. Rasch measurement theory (RMT) analysis was used to refine the scales and examine psychometric properties. RMT analysis supported the reliability and validity of 13 WOUND‐Q scales that measure wound characteristics (assessment, discharge, and smell), health‐related quality of life (life impact, psychological, sleep impact, and social), experience of care (information, home care nurses, medical team, and office staff), and wound treatment (dressing and suction device). The WOUND‐Q can be used to measure outcomes in research and clinical practice from the perspective of patients with any type of wound.
Cryoballoon ablation for paroxysmal atrial fibrillation: mid‐term outcome evaluated by ECG monitoring with an implantable loop recorder
Authors: Maj Riccardo , De Ceglia Sergio , Piazzi Elena , Pozzi Mattia , Montemerlo Elisabetta , Casiraghi Mirko , Fienga Marianna , Gressoni Sara , Rovaris Giovanni 
Published: March 2021

AbstractBackgroundThe success rate after cryoballoon ablation (CB‐A) performed for paroxysmal atrial fibrillation (PAF) might be overestimated by traditional noninvasive monitoring techniques. The purpose of this study was to evaluate the mid‐term outcome of CB‐A in patients with PAF implanted with an implantable loop recorder (ILR) after the procedure.MethodsBetween January 2017 and March 2019, all patients who underwent CB‐A for PAF and who were subsequently implanted with an ILR were retrospectively included. All devices were equipped with remote monitoring. All ILR‐documented atrial tachycardia (AT) or AF episodes ≥ 6 min were considered as recurrence; both true and false episodes were collected. A 3‐month post‐procedural blanking period (BP) was applied.ResultsA total of 102 patients (77 men, mean age 60.6 ± 9.6 years) who underwent pulmonary vein isolation (PVI) by CB‐A were included; mean time from first diagnosis of AF to PVI was 51.5 ± 46.9 months. Mean follow‐up was 29.3 ± 8.1 months; at 12‐month follow‐up, the success rate was 65.7%, while at 2‐year follow‐up, freedom from AT/AF recurrences was achieved in 59.3% of the patients. In the follow‐up, a total of 4987 ECG strips were analyzed; true‐positive episodes were confirmed in 2026 cases (40.6%), whereas 2961 episodes (59.4%) were considered false‐positive.ConclusionIn patients with PAF implanted with an ILR, CB‐A results in freedom from any AT/AF recurrence in 65.7% of patients at 12‐month follow‐up and in 59.3% of patients when evaluated at 2‐year. Careful adjudication of all ILR‐documented AF episodes is required to avoid misdiagnosis.
Unipolar electrogram‐based voltage mapping with far‐field cancellation to improve detection of abnormal atrial substrate during atrial fibrillation
Authors: Ragot Don , Nayyar Sachin , Massin Sophia Z. , Ha Andrew C. T. , Singh Sheldon M. , Labos Christopher , Suszko Adrian , Dalvi Rupin , Chauhan Vijay S. 
Published: March 2021

AbstractIntroductionAn important substrate for atrial fibrillation (AF) is fibrotic atrial myopathy. Identifying low voltage, myopathic regions during AF using traditional bipolar voltage mapping is limited by the directional dependency of wave propagation. Our objective was to evaluate directionally independent unipolar voltage mapping, but with far‐field cancellation, to identify low‐voltage regions during AF.MethodsIn 12 patients undergoing pulmonary vein isolation for AF, high‐resolution voltage mapping was performed in the left atrium during sinus rhythm and AF using a roving 20‐pole circular catheter. Bipolar electrograms (EGMs) (Bi) < 0.5 mV in sinus rhythm identified low‐voltage regions. During AF, bipolar voltage and unipolar voltage maps were created, the latter with (uni‐res) and without (uni‐orig) far‐field cancellation using a novel, validated least‐squares algorithm.ResultsUni‐res voltage was ~25% lower than uni‐orig for both low voltage and normal atrial regions. Far‐field EGM had a dominant frequency (DF) of 4.5–6.0 Hz, and its removal resulted in a lower DF for uni‐orig compared with uni‐res (5.1 ± 1.5 vs. 4.8 ± 1.5 Hz; p < .001). Compared with Bi, uni‐res had a significantly greater area under the receiver operator curve (0.80 vs. 0.77; p < .05), specificity (86% vs. 76%; p < .001), and positive predictive value (43% vs. 30%; p < .001) for detecting low‐voltage during AF. Similar improvements in specificity and positive predictive value were evident for uni‐res versus uni‐orig.ConclusionFar‐field EGM can be reliably removed from uni‐orig using our novel, least‐squares algorithm. Compared with Bi and uni‐orig, uni‐res is more accurate in detecting low‐voltage regions during AF. This approach may improve substrate mapping and ablation during AF, and merits further study.
Wall thickness‐based adjustment of ablation index improves efficacy of pulmonary vein isolation in atrial fibrillation: Real‐time assessment by intracardiac echocardiography
Authors: Motoike Yuji , Harada Masahide , Ito Takehiro , Nomura Yoshihiro , Nishimura Asuka , Koshikawa Masayuki , Watanabe Eiichi , Ozaki Yukio , Izawa Hideo 
Published: March 2021

AbstractBackgroundAblation index (AI) linearly correlates with lesion depth and may yield better therapeutic performance in pulmonary vein isolation (PVI) when tailored to a patient's wall thickness (WT) in the left atrium (LA).Methods and resultsFirst study: In paroxysmal atrial fibrillation patients (PAF; n = 20), the average LA WT (mm) in each anatomical segment for PVI was measured by intracardiac echocardiography (ICE) placed in the LA; the optimal AI for creating 1‐mm transmural lesion (AI/mm) was calculated. Second study: PAF (n = 80) patients were randomly assigned either to a force‐time integral protocol (FTI; 400 g·s, n = 40) or a tailored‐AI protocol (TAI; n = 40). In TAI, the LA WT in each segment was individually measured by ICE before starting ablation; a target AI was adjusted according to the individual WT in each segment (AI/mm × WT). The acute procedure outcomes and the 1‐year AF‐recurrence rate were compared between FTI and TAI. TAI had higher success rate of first‐pass isolation (88% vs. 65%) and had lower incidence of residual PV‐potentials/conduction‐gaps after a circular ablation than FTI (15% vs. 45%). The procedure time to complete PVI decreased in TAI compared to FTI (52 vs. 83 min), being attributed to the increased radiofrequency power and the decreased radiofrequency application time in each point in TAI. TAI had a lower 1‐year AF‐recurrence rate than FTI.ConclusionTAI increased acute procedure success, decreased time for PVI, and reduced the 1‐year AF‐recurrence rate, compared to FTI. Understanding the precise ablation target and tailoring AI would improve the efficacy of PVI.
Interpreting Legitimation Through Participation: The ASEAN Civil Society Conference
Authors: Gerard Kelly 
Published: March 2021

AbstractThe dynamics of the relationship between political participation and legitimacy have received limited attention, despite the widely held view that the former contributes to the latter. This article advances conceptualizations of this relationship by demonstrating how participatory innovations can be analysed as processes of legitimation. Studies of participation highlight how institutional actors define the terms of participation, but do not attend to how these terms function in constructing legitimacy. Studies of legitimation, conversely, emphasize participation but pay limited attention to how participatory innovations form. Building on these linkages, the article describes how the modes of participation framework can be used to evaluate the legitimating potential of participatory innovations and demonstrates this in the case of the Association of Southeast Asian Nations Civil Society Conference. The article demonstrates that more participation does not necessarily increase legitimacy, and calls for greater attention to what is being legitimated and to whom through participatory innovations.
Transcriptomic, peptidomic, and mass spectrometry imaging analysis of the brain in the ant Cataglyphis nodus
Authors: Habenstein Jens , Schmitt Franziska , Liessem Sander , Ly Alice , Trede Dennis , Wegener Christian , Predel Reinhard , Rössler Wolfgang , Neupert Susanne 
Published: March 2021

AbstractBehavioral flexibility is an important cornerstone for the ecological success of animals. Social Cataglyphis nodus ants with their age‐related polyethism characterized by age‐related behavioral phenotypes represent a prime example for behavioral flexibility. We propose neuropeptides as powerful candidates for the flexible modulation of age‐related behavioral transitions in individual ants. As the neuropeptidome of C. nodus was unknown, we collected a comprehensive peptidomic data set obtained by transcriptome analysis of the ants’ central nervous system combined with brain extract analysis by Q‐Exactive Orbitrap mass spectrometry (MS) and direct tissue profiling of different regions of the brain by matrix‐assisted laser desorption/ionization time‐of‐flight (MALDI‐TOF) MS. In total, we identified 71 peptides with likely bioactive function, encoded on 49 neuropeptide‐, neuropeptide‐like, and protein hormone prepropeptide genes, including a novel neuropeptide‐like gene (fliktin). We next characterized the spatial distribution of a subset of peptides encoded on 16 precursor proteins with high resolution by MALDI MS imaging (MALDI MSI) on 14 µm brain sections. The accuracy of our MSI data were confirmed by matching the immunostaining patterns for tachykinins with MSI ion images from consecutive brain sections. Our data provide a solid framework for future research into spatially resolved qualitative and quantitative peptidomic changes associated with stage‐specific behavioral transitions and the functional role of neuropeptides in Cataglyphis ants.
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Eavesdropping: The craft of social inquiry
Authors: Russi Luigi 
Published: March 2021

AbstractThis article is an exploration of John Shotter's suggestion to approach social inquiry as a ‘craft’. To take this suggestion seriously calls for making visible the specific ‘skills’ that conjure social inquiry into being, as craft. For this reason, the article presents small vignettes—drawn from the author's practice of supervision of researcher‐practitioners—that elucidate some of the turbulent passages that social researchers learn to negotiate, as they ‘acrobatically’ stretch themselves to eavesdrop on the messy trails of world‐making activity they are thrown into, as they participate in a social milieu. From waiting at awkward thresholds that do not announce an agenda; to approaching mis‐takes as occasions for bringing experience to articulation; to registering the pregnancy of silences that meet language at its edge. Just like Joyce's masterpiece Finnegans Wake brings into visibility the work that readers must perform to engage with its messy text, so this article argues that social inquiry as craft involves becoming skilled in various heuristic moves, through which social worlds can be listened into articulation.
Anaerobic bacterial response to nitric oxide stress: Widespread misconceptions and physiologically relevant responses
Authors: Cole J. A. 
Published: March 2021

AbstractHow anaerobic bacteria protect themselves against nitric oxide‐induced stress is controversial, not least because far higher levels of stress were used in the experiments on which most of the literature is based than bacteria experience in their natural environments. This results in chemical damage to enzymes that inactivates their physiological function. This review illustrates how transcription control mechanisms reveal physiological roles of the encoded gene products. Evidence that the hybrid cluster protein, Hcp, is a major high affinity NO reductase in anaerobic bacteria is reviewed: if so, its trans‐nitrosation activity is a nonspecific secondary consequence of chemical inactivation. Whether the flavorubredoxin, NorV, is equally effective at such low [NO] is unknown. YtfE is proposed to be an enzyme rather than a source of iron for the repair of iron‐sulfur proteins damaged by nitrosative stress. Any reaction catalyzed by YtfE needs to be revealed. The concentration of NO that accumulates in the cytoplasm of anaerobic bacteria is unknown, but indirect evidence indicates that it is in the pM to low nM range. Also unknown are the functions of the NO‐inducible cytoplasmic proteins YgbA, YeaR, or YoaG. Experiments to resolve some of these questions are proposed.
Rewilding Language Education: Emergent Assemblages and Entangled Actions
Authors: THORNE STEVEN L. , HELLERMANN JOHN , JAKONEN TEPPO 
Published: March 2021

AbstractIntegrating concepts and techniques from ethnomethodology and sociomaterialism, this article investigates the observable material processes involving human action and place‐based contexts of language use enabled by locative media. The focal pedagogical intervention utilized mobile augmented reality (AR) activities, the development of which was inspired by research on learning ‘in the wild.’ Applying the principle of reverse engineering, we introduce a pedagogical approach termed ‘rewilding’ for its emphasis on designing supportive conditions for goal‐directed interaction outside of classrooms. Three instances of AR materials use are presented from an out‐of‐class activity associated with university‐level language courses involving a quest‐type AR game calledChronoOps. Video data of 3‐player groups were transcribed using conventions from multimodal conversation analysis. The empirical investigation illustrates meaning making through visible embodied displays, the performance of new actions through incorporation of public semiotic resources, and the contributions of the material surround as actants in the flow of interaction. Analysis illustrates that mobile AR activities enable languaging events among assemblages of environments, mobile devices, and embodied experience. We conclude by outlining the affordances of mobile AR activities as one example of rewilding approaches to creating material conditions for language use and learning.
Student Self‐Initiated Use of Smartphones in Multilingual Writing Classrooms: Making Learner Agency and Multiple Involvements Visible
Authors: MATSUMOTO YUMI 
Published: March 2021

AbstractThis study examines students’ self‐initiated use of smartphones in multilingual writing classrooms in English‐language programs at a U.S. university. Responding to calls for empirical research on materials use in second‐language (L2) classrooms, researchers have focused on the roles of language learning and teaching materials in various L2 classroom contexts. Despite widespread access to smartphones among university students, how these students self‐initiate use of smartphones for learning in L2 classrooms in noninterventional settings (cf. mobile‐assisted language learning, which is often implemented for pedagogical purposes) has been under‐researched. Employing linguistic ethnography along with a multimodal approach, this study examines moments (a) when L2 learners select smartphones as a relevant resource for learning and (b) when learner agency (e.g., Larsen–Freeman, 2019) and multiple involvements (i.e., simultaneously engaging in multiple activities and responsibilities as interlocutors; see Greer, 2016) become visible while students self‐initiate smartphone use. It highlights how smartphones enable L2 learners to access diverse semiotic resources, maintain long turns by gazing at the devices, gain epistemic authority or primacy with those resources, resolve communicative problems, and change interactional dynamics.
Empirically Defining Language Learning and Teaching Materials in Use Through Sociomaterial Perspectives
Authors: GUERRETTAZ ANNE MARIE , ENGMAN MEL M. , MATSUMOTO YUMI 
Published: March 2021

AbstractLanguage learning and teaching (LLT) materials—like teacher‐created handouts, textbooks, and overhead transparencies—are central elements of language classrooms worldwide. Nonetheless, how language students and teachers actually engage with and deploy LLT materials has rarely been the focus of research. In response, this issue offers the first compilation of classroom‐based studies of ‘materials use’ in language education and includes research on Ojibwe, Japanese, French, and English language pedagogy. In this introductory article to the special issue, we set the stage for the 7 empirical articles by offering much‐needed definitions for the concepts of ‘LLT materials’ and ‘materials use.’ These definitions are based on a metasynthesis (i.e., an integrative qualitative analysis) of all of the materials used throughout the 7 empirical articles. Additionally, we explore sociomaterialism as a compelling and well‐suited framework for the study of materials in use. Sociomaterialism is not a unified theory but rather a research orientation that seeks to examine connections between the social and the material world. In addition to substantively and theoretically advancing the field, all the articles of this special issue also have practical implications for language pedagogy.
Movement‐induced hypoalgesia: behavioral characteristics and neural mechanisms
Authors: Lu Xuejing , Yao Xinru , Thompson William Forde , Hu Li 
Published: March 2021

AbstractPain is essential for our survival because it helps to protect us from severe injuries. Nociceptive signals may be exacerbated by continued physical activities but can also be interrupted or overridden by physical movements, a process called movement‐induced hypoalgesia. Several neural mechanisms have been proposed to account for this effect, including the reafference principle, non‐nociceptive interference, and top‐down descending modulation. Given that the hypoalgesic effects of these mechanisms temporally overlap during movement execution, it is unclear whether movement‐induced hypoalgesia results from a single neural mechanism or from the joint action of multiple neural mechanisms. To address this question, we conducted five experiments on 129 healthy humans by assessing the hypoalgesic effect after movement execution. Combining psychophysics and electroencephalographic recordings, we quantified the relationship between the strength of voluntary movement and the hypoalgesic effect, as well as the temporal and spatial characteristics of the hypoalgesic effect. Our findings demonstrated that movement‐induced hypoalgesia results from the joint action of multiple neural mechanisms. This investigation is the first to disentangle the distinct contributions of different neural mechanisms to the hypoalgesic effect of voluntary movement, which extends our understanding of sensory attenuation arising from voluntary movement and may prove instrumental in developing new strategies for pain management.
Selective IgM deficiency: Follow‐up and outcome
Authors: Caka Canan , Cimen Ozlem , Kahyaoğlu Pinar , Tezcan İlhan , Cagdas Deniz 
Published: March 2021

AbstractBackgroundSelective IgM deficiency (sIgMD) is classified under primary immunodeficiencies (PID). This study aimed to define the clinical and immunologic features of sIgMD.Patient and MethodsWe assessed a retrospective medical record of patients who fulfilled the diagnostic criteria for sIgMD in a pediatric immunology department.ResultsThere were 55 patients with sIgMD. Out of 55 patients, 13 (23.6%) patients, diagnosed with a well‐defined PID disease, and nine, evaluated as transient hypogammaglobulinemia, were excluded in the follow‐up. The ratio of the sIgMD was %0.12 in the outpatient clinic of pediatric immunology (33/27,000). Out of 33 patients, eight (24,2%) were asymptomatic during the follow‐up period. Fifteen (45.4%) patients presented with upper/lower respiratory and skin infections. Six patients (18%) had chromosomal anomaly, or syndrome (trisomy 21, 22q11.2 deletion 1p deletion, CHARGE syndrome, and Cohen syndrome). Six (18%) had autoimmune/inflammatory diseases, such as Behcet's disease, immune thrombocytopenic purpura, Crohn's disease, Guillain‐Barre syndrome, and diabetes mellitus. Five (15%) had allergic disorders. Three patients (9%) developed malignancy. The PID diagnoses were combined immunodeficiency, common variable immunodeficiency, chronic granulomatous disease, adenosine deaminase deficiency, and congenital neutropenia.ConclusionGenetic disorders, autoimmune/inflammatory, and allergic diseases may accompany sIgMD. Approximately 25% of the patients were asymptomatic in our series. Patients had increased malignancy risk. We diagnosed about 25% of the patients having low IgM with a specific PID in the follow‐up period. Thus, patients with sIgMD should be followed up regularly in immunology clinics.
Antithymocyte globulin induction therapy and myocardial complement deposition in pediatric heart transplantation
Authors: Ghaleb Stephanie , Wittekind Samuel G. , Martinez Hugo , Kasten Jennifer , Gao Zhiqian , Hengehold Tricia , Chin Clifford 
Published: March 2021

AbstractBackgroundAntithymocyte globulin (ATG) consists of polyclonal antibodies directed primarily against human T lymphocytes but may contain antibodies with affinity for other tissues in the transplanted organ, resulting in complement (C4d) deposition. This phenomenon has been demonstrated in endomyocardial biopsies (EMBs) of adult cardiac transplants. We examined the relationship of induction immunosuppression with ATG and C4d deposition in EMB of pediatric cardiac transplants.MethodsResults of C4d immunohistochemistry were available from all EMB of patients transplanted at our center between June 2012 and April 2018 (n = 48) who received induction immunosuppression with either ATG (n = 20) or basiliximab (n = 28) as the standard of care.ResultsC4d deposition in the first year post–heart transplant was more commonly seen among patients who received ATG induction (20% of EMBs in ATG group vs 1% of EMBs in basiliximab group; p < .0001). C4d deposition related to ATG was observed early post‐transplant (50% ATG vs 0% basiliximab on first EMB; p < .0001 and 35% ATG vs 0% basiliximab on the second EMB; p = .0012). While this difference waned by the third EMB (5% ATG vs 0% basiliximab; p = .41), positive C4d staining persisted to the sixth EMB in the ATG group only (6%).ConclusionC4d deposition is common on EMB up to 1 year post–pediatric cardiac transplant following ATG induction. This high rate of positive C4d staining in the absence of histologic AMR after ATG induction therapy must be accounted for in making clinical decisions regarding cardiac allograft rejection diagnosis and treatment.