bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why so few Nobel Prizes for cancer researchers? An analysis of Nobel Prize nominations for German physicians with a focus on Ernst von Leyden and Karl Heinrich Bauer
Authors: Hansson Nils , Padrini Giacomo , Moll Friedrich H. , Halling Thorsten , Timmermann Carsten 
Published: May 2021

AbstractPurposeTo date, 11 scientists have received the Nobel Prize for discoveries directly related to cancer research. This article provides an overview of cancer researchers nominated for the Nobel Prize from 1901 to 1960 with a focus on Ernst von Leyden (1832–1910), the founder of this journal, and Karl Heinrich Bauer (1890–1978).MethodsWe collected nominations and evaluations in the archive of the Nobel committee of physiology or medicine in Sweden to identify research trends and to analyse oncology in a Nobel Prize context.ResultsWe found a total of 54 nominations citing work on cancer as motivation for 11 candidates based in Germany from 1901 to 1953. In the 1930s, the US became the leading nation of cancer research in a Nobel context with nominees like Harvey Cushing (1869–1939) and George N. Papanicolaou (1883–1962).DiscussionThe will of Alfred Nobel stipulates that Nobel laureates should have “conferred the greatest benefit to mankind”. Why were then so few cancer researchers recognized with the Nobel medal from 1901 to 1960? Our analysis of the Nobel dossiers points at multiple reasons: (1) Many of the proposed cancer researchers were surgeons, and surgery has a weak track record in a Nobel context; (2) several scholars were put forward for clinical work and not for basic research (historically, the Nobel committee has favoured basic researchers); (3) the scientists were usually not nominated for a single discovery, but rather for a wide range of different achievements.
Native trees provide more benefits than exotic trees when ecosystem services are weighted in Santiago, Chile
Authors: Arcos-LeBert Gabriela , Aravena-Hidalgo Tamara , Figueroa Javier A. , Jaksic Fabián M. , Castro Sergio A. 
Published: May 2021

AbstractUrban forests are conformed by a variable representation of native and exotic species. Because these species differ in the morpho-functional traits that possess, they may have a differential participation in the provision of ecosystem services in cities. Here, we compare ecosystem services inferred from morpho-functional traits of native and exotic tree species present in Santiago, Chile. Five traits associated with ecosystem services valuation (Vi) were scored (1 versus 0), and compared between native and exotic tree species, weighting those ecosystem services according to multi-criteria decision analysis procedure (MCDA). We found that native and exotic species did not have significant differences in the ecosystem services provided to urban dwellers (F = 1.2; P > 0.05); but these results were obtained when ecosystem services were not weighted according to their demand in Santiago. When weights were pondered, native species provided more ecosystem services than did exotic trees (F = 7.1; P < 0.008). Complementarily, we also found that the ecosystem services ranked for native and exotic species did not correlate with their spatial distribution (occupancy, Oi). These results highlight the need to use criteria based on ecosystem services to tree planting in Santiago, prioritizing native species because, in comparison to exotic ones, they provide more ecosystem services demanded city dwellers.
Assessment of sleep problems with the Insomnia Severity Index (ISI) and the sleep item of the Patient Health Questionnaire (PHQ-9) in cancer patients
Authors: Schulte Thomas , Hofmeister Dirk , Mehnert-Theuerkauf Anja , Hartung Tim , Hinz Andreas 
Published: May 2021

Abstract
Objective
The objectives of this study were to examine sleep problems in cancer patients, to test the psychometric properties of the Insomnia Sleep Index (ISI) in comparison with the sleep item of the Patient Health Questionnaire-9 (PHQ-9), and to analyze disrupting factors which might cause the sleep problems.

Methods
A sample of 1026 mixed-site cancer patients in treatment at a German oncological rehabilitation clinic was examined.

Results
The reliability of the ISI was very good (Cronbach’s alpha = 0.92), and the results of the confirmatory factor analysis were acceptable. Females reported worse sleep quality (ISI mean: 13.7 ± 6.6) than males (10.7 ± 6.4). Sleep problems as measured with the PHQ-9 sleep item were markedly higher than those in the general population (effect size d = 1.15).
Patients reported that, of the factors that disrupted their sleep, psychological factors (brooding, worries) were more relevant than symptom factors (pain, nocturnal urination, or restless legs).

Conclusions
The ISI is effective in detecting sleep problems in cancer patients. Normative studies with the ISI would be helpful for assessing ISI mean scores. Sex differences should be taken into account when groups of patients are compared. The sleep item of the PHQ-9 can be used in epidemiological studies.
Transcultural differences in suicide attempts among children and adolescents with and without migration background, a multicentre study: in Vienna, Berlin, Istanbul
Authors: Özlü-Erkilic Zeliha , Diehm Robert , Wenzel Thomas , Bingöl Ҫağlayan R. Hülya , Güneş Hatice , Üneri Özden Şükran , Winter Sibylle , Akkaya-Kalayci Türkan 
Published: May 2021

AbstractWhile suicide can occur throughout the lifespan, worldwide suicide is the second leading cause of death among young people aged between 15 and 29 years. The aim of this multicentre study, conducted in Austria, Germany and Turkey, is to investigate the transcultural differences of suicide attempts among children and adolescents with and without migration background. The present study is a retrospective analyses of the records of 247 young people, who were admitted after a suicide attempt to Emergency Outpatient Clinics of Departments of Child and Adolescent Psychiatry of the collaborating Universities including Medical University of Vienna, Charité University Medicine Berlin and Cerrahpaşa School of Medicine and Bakirkoy Training and Research Hospital for Mental Health in Istanbul over a 3-year period. The results of the present study show significant transcultural differences between minors with and without migration background in regard to triggering reasons, method of suicide attempts and psychiatric diagnosis. The trigger event “intra-familial conflicts” and the use of “low-risk methods” for their suicide attempt were more frequent among patients with migration background. Moreover among native parents living in Vienna and Berlin divorce of parents were more frequent compared to parents living in Istanbul and migrants in Vienna. These results can be partly explained by cultural differences between migrants and host society. Also disadvantages in socio-economic situations of migrants and their poorer access to the healthcare system can mostly lead to acute and delayed treatments. Larger longitudinal studies are needed to understand better the impact of migration on the suicidal behaviour of young people.
Characterization of the DdrD protein from the extremely radioresistant bacterium Deinococcus radiodurans
Authors: de la Tour Claire Bouthier , Mathieu Martine , Servant Pascale , Coste Geneviève , Norais Cédric , Confalonieri Fabrice 
Published: May 2021

AbstractHere, we report the in vitro and in vivo characterization of the DdrD protein from the extraordinary stress-resistant bacterium, D. radiodurans. DdrD is one of the most highly induced proteins following cellular irradiation or desiccation. We confirm that DdrD belongs to the Radiation Desiccation Response (RDR) regulon protein family whose expression is regulated by the IrrE/DdrO proteins after DNA damage. We show that DdrD is a DNA binding protein that binds to single-stranded DNA In vitro, but not to duplex DNA unless it has a 5′ single-stranded extension. In vivo, we observed no significant effect of the absence of DdrD on the survival of D. radiodurans cells after exposure to γ-rays or UV irradiation in different genetic contexts. However, genome reassembly is affected in a ∆ddrD mutant when cells recover from irradiation in the absence of nutrients. Thus, DdrD likely contributes to genome reconstitution after irradiation, but only under starvation conditions. Lastly, we show that the absence of the DdrD protein partially restores the frequency of plasmid transformation of a ∆ddrB mutant, suggesting that DdrD could also be involved in biological processes other than the response to DNA damage.
Inducing a desired value of correlation between two point-scale variables: a two-step procedure using copulas
Authors: Barbiero Alessandro 
Published: May 2021

AbstractFocusing on point-scale random variables, i.e. variables whose support consists of the first m positive integers, we discuss how to build a joint distribution with pre-specified marginal distributions and Pearson’s correlation $$\rho $$
ρ
. After recalling how the desired value $$\rho $$
ρ
is not free to vary between $$-1$$

-
1

and $$+1$$

+
1

, but generally ranges a narrower interval, whose bounds depend on the two marginal distributions, we devise a procedure that first identifies a class of joint distributions, based on a parametric family of copulas, having the desired margins, and then adjusts the copula parameter in order to match the desired correlation. The proposed methodology addresses a need which often arises when assessing the performance and robustness of some new statistical technique, i.e. trying to build a huge number of replicates of a given dataset, which satisfy—on average—some of its features (for example, the empirical marginal distributions and the pairwise linear correlations). The proposal shows several advantages, such as—among others—allowing for dependence structures other than the Gaussian and being able to accommodate the copula parameter up to an assigned level of precision for $$\rho $$
ρ
with a very small computational cost. Based on this procedure, we also suggest a two-step estimation technique for copula-based bivariate discrete distributions, which can be used as an alternative to full and two-step maximum likelihood estimation. Numerical illustration and empirical evidence are provided through some examples and a Monte Carlo simulation study, involving the CUB distribution and three different copulas; an application to real data is also discussed.
Gulls of a feather do not sleep whenever—circadian rhythm of activity of black-headed gulls Chroicocephalus ridibundus during the incubation period
Authors: Indykiewicz Piotr , Jakubas Dariusz , Gerke Julita 
Published: May 2021

AbstractMany vertebrates exhibit a diel activity, steered by light–dark cycle. However, some colonial waterbirds, in that several species of gulls, are active not only in day hours but also at night. In this study, we aimed to investigate 24 h cycle of black-headed gulls (BHG)Chroicocephalus ridibundusactivity with focus on sleep behaviour. We expected that 24 h patterns of activity differ between colonies located in various habitats, and within a colony between nests located in the centre vs at the edge. We studied behaviour based on 9600 of 30 s videos from camera-traps taken in six colonies and data from 10 GPS-tracked individuals from one colony recorded during incubation. BHGs stayed active on average during 48.1% of a night, mainly spent on passive and active nest defence, and on nest maintenance. BHGs spent similar time on these activities in day hours. Individuals breeding in the colony centre slept at night longer than those at its edge. BHGs stayed active during on average 76.5% of daytime. In two urban colonies with the highest nest densities and highest level of light pollution birds slept less during the day than in other studied colonies (three rural and one urban) characterized by lower densities and light intensity after sunset near the colony. Knowledge of nocturnal behaviour is crucial to comprehend 24 h activity patterns of an organism, especially to understand flexibility of behaviour crucial for restoration, like sleep.
Unveiling endogeneity between competition and efficiency in Chinese banks: a two-stage network DEA and regression analysis
Authors: Tan Yong , Wanke Peter , Antunes Jorge , Emrouznejad Ali 
Published: May 2021

AbstractAlthough there is a growing number of research articles investigating the performance in the banking industry, research on Chinese banking efficiency is rather focused on discussing rankings to the detriment of unveiling its productive structure in light of banking competition. This issue is of utmost importance considering the relevant transformations in the Chinese economy over the last decades. This is a development of a two-stage network production process (production and intermediation approaches in banking, respectively) to evaluate the efficiency level of Chinese commercial banks. In the second stage regression analysis, an integrated Multi-Layer Perceptron/Hidden Markov model is used for the first time to unveil endogeneity among banking competition, contextual variables, and efficiency levels of the production and intermediation approaches in banking. The competitive condition in the Chinese banking industry is measured by Panar–Rosse H-statistic and Lerner index under the Ordinary Least Square regression. Findings reveal that productive efficiency appears to be positively impacted by competition and market power. Second, credit risk analysis in older local banks, which focus the province level, would possibly be the fact that jeopardizes the productive efficiency levels of the entire banking industry in China. Thirdly, it is found that a perfect banking competition structure at the province level and a reduced market power of local banks are drivers of a sound banking system. Finally, our findings suggest that concentration of credit in a few banks leads to an increase in bank productivity.
Using ontology to guide reinforcement learning agents in unseen situations
Authors: Ghanadbashi Saeedeh , Golpayegani Fatemeh 
Published: May 2021

AbstractIn multi-agent systems, goal achievement is challenging when agents operate in ever-changing environments and face unseen situations, where not all the goals are known or predefined. In such cases, agents need to identify the changes and adapt their behaviour, by evolving their goals or even generating new goals to address the emerging requirements. Learning and practical reasoning techniques have been used to enable agents with limited knowledge to adapt to new circumstances. However, they depend on the availability of large amounts of data, require long exploration periods, and cannot help agents to set new goals. Furthermore, the accuracy of agents’ actions is improved by introducing added intelligence through integrating conceptual features extracted from ontologies. However, the concerns related to taking suitable actions when unseen situations occur are not addressed. This paper proposes a new Automatic Goal Generation Model (AGGM) that enables agents to create new goals to handle unseen situations and to adapt to their ever-changing environment on a real-time basis. AGGM is compared to Q-learning, SARSA, and Deep Q Network in a Traffic Signal Control System case study. The results show that AGGM outperforms the baseline algorithms in unseen situations while handling the seen situations as well as the baseline algorithms.
Are the “100 of the world’s worst” invasive species also the costliest?
Authors: Cuthbert Ross N. , Diagne Christophe , Haubrock Phillip J. , Turbelin Anna J. , Courchamp Franck 
Published: May 2021

AbstractBiological invasions are increasing worldwide, damaging ecosystems and socioeconomic sectors. Two decades ago, the “100 of the world’s worst” invasive alien species list was established by the IUCN to improve communications , identifying particularly damaging ‘flagship’ invaders globally (hereafter, worst). Whilst this list has bolstered invader awareness, whether worst species are especially economically damaging and how they compare to other invaders (hereafter, other) remain unknown. Here, we quantify invasion costs using the most comprehensive global database compiling them (InvaCost). We compare these costs between worst and other species against sectorial, taxonomic and regional descriptors, and examine temporal cost trends. Only 60 of the 100 worst species had invasion costs considered as highly reliable and actually observed estimates (median: US$ 43 million). On average, these costs were significantly higher than the 463 other invasive species recorded in InvaCost (median: US$ 0.53 million), although some other species had higher costs than most worst species. Damages to the environment from the worst species dominated, whereas other species largely impacted agriculture. Disproportionately highest worst species costs were incurred in North America, whilst costs were more evenly distributed for other species; animal invasions were always costliest. Proportional management expenditures were low for the other species, and surprisingly, over twice as low for the worst species. Temporally, costs increased more for the worst than other taxa; however, management spending has remained very low for both groups. Nonetheless, since 40 species had no robust and/or reported costs, the “true” cost of “some of the world’s worst” 100 invasive species still remains unknown.
Tracking the outbreak: an optimized sequential adaptive strategy for Xylella fastidiosa delimiting surveys
Authors: Lázaro E. , Sesé M. , López-Quílez A. , Conesa D. , Dalmau V. , Ferrer A. , Vicent A. 
Published: May 2021

AbstractThe EU plant health legislation enforces the implementation of intensive surveillance programs for quarantine pests. After an outbreak, surveys are implemented to delimit the extent of the infested zone and to manage disease control. Surveillance in agricultural and natural environments can be enhanced by increasing the survey efforts. Budget constraints often limit inspection and sampling intensities, thus making it necessary to adapt and optimize surveillance strategies. A sequential adaptive delimiting survey involving a three-phase and a two-phase design with increasing spatial resolution was developed and implemented for theXylella fastidiosademarcated area in Alicante, Spain. Inspection and sampling intensities were optimized using simulation-based methods. Sampling intensity thresholds were evaluated by quantifying their effect on the estimation ofX. fastidiosaincidence. This strategy made it possible to sequence inspection and sampling taking into account increasing spatial resolutions, and to adapt the inspection and sampling intensities according to the information obtained in the previous, coarser, spatial resolution. The proposed strategy was able to efficiently delimit the extent ofXylella fastidiosa, while improving on the efficiency and maintaining the efficacy of the official survey campaign. From a methodological perspective, our approach provides new insights into alternative delimiting designs and new reference sampling intensity values.
Integrating dark diversity and functional traits to enhance nature conservation of epiphytic lichens: a case study from Northern Italy
Authors: Trindade Diego Pires Ferraz , Pärtel Meelis , Carmona Carlos Pérez , Randlane Tiina , Nascimbene Juri 
Published: May 2021

AbstractMountains provide a timely opportunity to examine the potential effects of climate change on biodiversity. However, nature conservation in mountain areas have mostly focused on the observed part of biodiversity, not revealing the suitable but absent species—dark diversity. Dark diversity allows calculating the community completeness, indicating whether sites should be restored (low completeness) or conserved (high completeness). Functional traits can be added, showing what groups should be focused on. Here we assessed changes in taxonomic and functional observed and dark diversity of epiphytic lichens along elevational transects in Northern Italy spruce forests. Eight transects (900–1900 m) were selected, resulting in 48 plots and 240 trees, in which lichens were sampled using four quadrats per tree (10 × 50 cm). Dark diversity was estimated based on species co-occurrence (Beals index). We considered functional traits related to growth form, photobiont type and reproductive strategy. Linear and Dirichlet regressions were used to examine changes in taxonomic metrics and functional traits along gradient. Our results showed that all taxonomic metrics increased with elevation and functional traits of lichens differed between observed and dark diversity. At low elevations, due to low completeness and harsh conditions, both restoration and conservation activities are needed, focusing on crustose species. Towards high elevations, conservation is more important to prevent species pool losses, focusing on macrolichens, lichens withTrentepohliaand sexual reproduction. Finally, dark diversity and functional traits provide a novel tool to enhance nature conservation, indicating particular threatened groups, creating windows of opportunities to protect species from both local and regional extinctions.
Seeing the Quiet Politics in Unquiet Woods: A Different Vantage Point for a Future Forest Agenda
Authors: Arora-Jonsson Seema , Pierce Colfer Carol J. , González-Hidalgo Marien 
Published: May 2021

AbstractWe address two aspects of forest lives—violence and care—that are central to forest outcomes but often invisible in mainstream discussions on forests. We argue that questions of violence and care work in forests open up debates about what forests are, who defines them, and how. We draw primarily on feminist work on forestry, violence, and care to examine the gendered nature of forest conflicts and the ‘quiet politics’ of resistance to violence grounded in the everyday work of care that are crucial to understanding forests and their governance. We show how varied practices of resistance to violence and injustice are grounded in cooperative action of care and are an intrinsic part of shaping and regenerating forests. We highlight the importance of close attention to seemingly mundane actions rooted in people’s daily lives and experiences that shape forests.
Empathic Accuracy and Cognitive and Affective Empathy in Young Adults With and Without Autism Spectrum Disorder
Authors: McKenzie K. , Russell A. , Golm D. , Fairchild G. 
Published: May 2021

AbstractThis study investigated whether young adults with ASD (n = 29) had impairments in Cognitive Empathy (CE), Affective Empathy (AE) or Empathic Accuracy (EA; the ability to track changes in others’ thoughts and feelings) compared to typically-developing individuals (n = 31) using the Empathic Accuracy Task (EAT), which involves watching narrators recollecting emotionally-charged autobiographical events. Participants provided continuous ratings of the narrators’ emotional intensity (indexing EA), labelled the emotions displayed (CE) and reported whether they shared the depicted emotions (AE). The ASD group showed deficits in EA for anger but did not differ from typically-developing participants in CE or AE on the EAT. The ASD group also reported lower CE (Perspective Taking) and AE (Empathic Concern) on the Interpersonal Reactivity Index, a self-report questionnaire.