bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENINGKATAN MOTIVASI BELAJAR SISWA MELALUI LAYANAN BIMBINGAN KELOMPOK SMP NEGERI 2 SIMPANG HILIR
Authors: Wahyudin Wahyudin 
Published: August 2021

Penelitian ini dilaksanakan berdasarkan fenomena yang ada di SMP Negeri 2 Simpang Hilir yang menunjukkan terdapat siswa yang tingkat motivasi belajarnya rendah. Melalui layanan bimbingan kelompok diharapkan motivasi belajar siswa ini dapat ditingkatkan. Tujuan dari penelitian ini adalah untuk mengetahui gambaran motivasi belajar siswa sebelum mendapatkan layanan bimbingan kelompok, untuk mengetahui gambaran motivasi belajar siswa setelah mendapat layanan bimbingan kelompok, dan untuk mengetahui apakah motivasi belajar dapat ditingkatkan melalui layanan bimbingan kelompok.
Jenis penelitian yang digunakan dalam penelitian ini adalah Penelitian Tindakan Bimbingan dan Konseling dengan melaksanakan dua siklus. Subyek penelitian ini yaitu 10 siswa yang terdiri atas 8 siswa bermotivasi belajar rendah dan 2 siswa yang memiliki motivasi belajar tinggi, agar terjadi dinamika kelompok. Metode pengumpulan data yang digunakan yaitu wawancara, skala motivasi belajar dan observasi. Sedangkan teknik analisis datanya menggunakan analisis deskriptif persentase dan kualitatif.
Hasil penelitian menunjukkan bahwa motivasi belajar siswa sebelum memperoleh perlakuan berupa bimbingan kelompok, sebesar 44,4% kategori rendah. Setelah diberi layanan bimbingan kelompok pada sikus I, motivasi belajar siswa meningkat menjadi kategori sedang sebesar 65%. Sedangkan pada siklus II motivasi belajar siswa terus meningkat menjadi kategori tinggi dengan perolehan sebesar 74%. Hal ini menunjukkan layanan bimbingan kelompok dapat meningkatkan motivasi belajar pada siswa.
An efficient glomerular object locator for renal whole slide images using proposal-free network and dynamic scale evaluation method
Authors: Liu Xueyu , Li Ming , Wu Yongfei , Chen Yilin , Hao Fang , Zhou Daoxiang , Wang Chen , Ma Chuanfeng , Shi Guangze , Zhou Xiaoshuang 
Published: August 2021

In the diagnosis of chronic kidney disease, glomerulus as the blood filter provides important information for an accurate disease diagnosis. Thus automatic localization of the glomeruli is the necessary groundwork for future auxiliary kidney disease diagnosis, such as glomerular classification and area measurement. In this paper, we propose an efficient glomerular object locator in kidney whole slide image(WSI) based on proposal-free network and dynamic scale evaluation method. In the training phase, we construct an intensive proposal-free network which can learn efficiently the fine-grained features of the glomerulus. In the evaluation phase, a dynamic scale evaluation method is utilized to help the well-trained model find the most appropriate evaluation scale for each high-resolution WSI. We collect and digitalize 1204 renal biopsy microscope slides containing more than 41000 annotated glomeruli, which is the largest number of dataset to our best knowledge. We validate the each component of the proposed locator via the ablation study. Experimental results confirm that the proposed locator outperforms recently proposed approaches and pathologists by comparing F 1 and run time in localizing glomeruli from WSIs at a resolution of 0.25 μm/pixel and thus achieves state-of-the-art performance. Particularly, the proposed locator can be embedded into the renal intelligent auxiliary diagnosis system for renal clinical diagnosis by localizing glomeruli in high-resolution WSIs effectively.
Am I worthy to my leader? Role of leader-based self-esteem and social comparison in the LMX-performance relationship
Authors: Afshan Gul , Serrano-Archimi Carolina , Landry Guylaine , Javed Uzma 
Published: August 2021

BACKGROUND: Most leadership theories, such as transformational, ethical, and servant leadership, emphasize the notion that leaders influence their followers’ in-role and extra-role work performance by treating them collectively and similarly. On the other hand, leader-member exchange (LMX) theory challenges this idea and argues that leaders treat followers differently and have high-quality exchange relationships with some followers and low-quality ones with others. However, few studies have examined LMX differentiated relationships in social contexts. OBJECTIVE: This study aims to investigate the role of employee leader-based self-esteem (LBSE) (i.e., employees’ self-evaluation of their worth derived from the quality of the relationship with their supervisor) in the relationship between LMX and two types of performance: task performance and organizational citizenship behaviour at individual level (OCB-I). Using an integrated theoretical framework of social comparison and self-consistency theories, we develop a moderated mediation model in which the mediating role of LBSE in the LMX-task performance and OCB-I relationships is conditional on the values of LMX social comparison (LMXSC). METHODS: Using a research sample of 298 manager-employee matching dyads working in 43 branches of a leading bank in Pakistan, results of hierarchical multiple regression analyses provided support for our developed model. RESULTS: We found that LMX positively led to LBSE which, in turn, served as a mediator between LMX and both performance types, with a stronger effect on OCB-I. We also found that by moderating the relationship between LMX and LBSE, LMXSC moderated the mediating role of LBSE, which had stronger effect on performance at high values of LMXSC than at low values. CONCLUSIONS: Following these findings, we discuss the contributions that this study offers to LMX and self-esteem literature and its managerial implications.
First-Line Immuno-Oncology Combinations for Metastatic Clear Cell Renal Cell Carcinoma (mRCC): A Systematic Review of Phase III Clinical Trials
Authors: Hahn Andrew W. , Shah Amishi Y. , Campbell Matthew T. 
Published: August 2021

BACKGROUND: The introduction of immune checkpoint inhibitors rapidly changed treatment for patients with metastatic clear cell renal cell carcinoma (mRCC). First-line treatment now includes multiple immuno-oncology (IO) combinations that were approved over a short time period and were not directly compared in randomized clinical trials. Thus, clinicians face a challenge in individualizing first-line treatment to optimize clinical outcomes. OBJECTIVE: We sought to systematically review clinical outcomes for first-line IO combinations for patients with mRCC. METHODS: Literature reporting outcomes from phase III clinical trials that evaluated first-line IO combination therapies was identified through a search of the PubMed electronic database following PRISMA guidelines. Abstracts were screened to identify manuscripts that fit the search criteria, and then, a descriptive review was performed. RESULTS: Our literature search identified 2,229 abstracts that met the initial search criteria, and then, it was narrowed to 431 abstracts using filters for “clinical trial” and a “ten year” time window. After review of the abstracts, six manuscripts were selected for data extraction and subsequent review. CONCLUSION: When compared to sunitinib, four IO combinations improved overall survival as first-line treatment, and five improved progression free survival for patients with mRCC. These IO combination therapies have unique characteristics, so clinicians should take into account patient and cancer factors to individualize treatment recommendations.
Analisis Aerodinamika Bodi Mobil Hemat Energi Kelas Urban Menggunakan Simulasi Computational Fluid Dynamics
Authors: Vajra Glaudius Alexander , Tobing Sheila , Iskandar Isdaryanto 
Published: August 2021

Kontes Mobil Hemat Energi (KMHE) merupakan kompetisi nasional yang diselenggarakan setiap tahun untuk menguji kemampuan merancang dan mengompetisikan kendaraan yang ramah lingkungan. Sejak tahun 2017, Universitas Katolik Indonesia Atma Jaya secara rutin mengikuti kompetisi ini melalui Workshop Mesin UNIKA Atma Jaya (WSM) pada kategori Urban. Penelitian ini bertujuan untuk menghasilkan desain bodi yang aerodinamis dengan target nilai koefisien gaya hambat lebih rendah dari 0,35 (<em>C<sub>D</sub></em> <sub> </sub>0,35). Penelitian dilakukan menggunakan simulasi CFD pada software ANSYS v17.2. Perancangan bodi dimulai dengan membuat desain base model untuk menyesuaikan dengan regulasi KMHE 2019 serta sasis dan komponen kelistrikan yang baru. Modifikasi desain base model dilakukan untuk mencapai target nilai <em>C<sub>D</sub></em>. Modifikasi yang dilakukan berupa penambahan <em>spoiler</em>, membuat coakan pada bagian bawah di sisi belakang kendaraan dan memperhalus sudut tajam pada desain bodi. Modifikasi tersebut menghasilkan desain bodi dengan nilai <em>C<sub>D</sub></em> rata-rata sebesar 0,295183 yang akan digunakan oleh tim WSM untuk menghadapi KMHE 2021.
Henoch Schönlein Purpura / Ig A Vasculitis in Children and Risk Factors for Renal Involvement
Authors: Demir Selcan , Candan Cengiz , Turhan Pınar , Ergüven Müferet 
Published: August 2021

Objective: Henoch Schönlein Purpura also known as IgA vasculitis is the most common form of pediatric vasculitis and renal involvement is responsible for the mortality and long-term morbidity. We aimed to describe the epidemiological, clinical, and laboratory characteristics of patients with IgAV and analyze the predicting factors associated with renal involvement.
Materials and Methods: This study included188 children diagnosed with IgA vasculitis. Demographical, and clinical data were retrospectively reviewed from the patient files.
Results: Of the 188 IgA vasculitis patients, 51.6% were female. The mean±SD age at diagnosis was 8.49±3.35 years, and 66% of them were diagnosed before 10 years of age. All the patients had palpable purpura, 35.6% had arthritis, 34.6% had gastrointestinal system involvement, 12.2% had renal disorders, at the time of diagnosis. Besides 23(12.2%) patients presented with renal involvement, 42(22%) patients developed renal involvement at follow-up. Patients under 10 years of age had significantly more arthritis, patients over 10 years of age had significantly more renal involvement. Among laboratory work-up, erythrocyte sedimentation rate levels were found significantly higher in patients with renal involvement. In multivariate analysis, the occurrence of renal involvement was not associated with any of the defined demographic and clinical characteristics of the disease. Although erythrocyte sedimentation rate levels showed a higher risk ratio, it has only borderline significance.
Conclusion: Although IgA vasculitis is a self-limiting disease, renal involvement can cause serious complications. In the presented study, being older than 10 years of age and having high levels of erythrocyte sedimentation rate at the time of diagnosis could serve as a possible predictor of renal involvement.
Формування областей основних параметрів модифікацій транспортного літака за умовами його базування
Authors: Двейрін Олександр Захарович , Рябков Віктор Іванович , Капітанова Людмила Валеріївна , Кириленко Марина Володимирівна 
Published: August 2021

Along with the unique flight performance indicators and economic indicators that characterize heavy transport aircraft, the priority is also to ensure the basing for their heavier modifications at the airfields declared for the base aircraft. This problem arises at the very early stage of the modification creation, when its main parameters such as the gross mass at takeoff and thrust-to-weight ratio are formed. This is due to the very essence of creating a modification ‑ increasing its carrying capacity (which leads to increase in the gross mass at takeoff and flight range ) with an increased payload by increasing the mass of fuel on board. Ensuring growth of flight and hour , performance underlies the creation of all modifications of transport category aircraft. For heavier modifications than their base aircraft, it is further complicated by the fact that the base models are based on the runways of the second and first class airfields, which creates an insurmountable limitation on the available runway length. The second limitation is the value of the decision-making speed during takeoff, in case of failure of the critical engine during the takeoff run, which predetermines the required length of the runway. Since the takeoff masses of aircraft modifications of this type continue to increase, the problem of their basing on the runways of existing airfields arises by forming the takeoff weight relationship – decision-making speed in case of a critical engine failure ‑ thrust-to-weight ratio, providing the basing of a heavier modification at the airfield declared for the base aircraft . To implement this condition, a model for determining the speed , in which a safe termination of the takeoff run is possible in the event of a critical engine failure. The resulting model allows to take into account a number of restrictions due to the properties of heavy aircraft, such as the minimum and maximum thrust of the cruise engines, which makes it possible to make reasonable recommendations in the operating rules for aircraft of this type. Taking into account the expressions obtained to determine , a model has been formed to determine and assess the required thrust-to-weight ratio of a heavier modification by condition for modifications with a takeoff weight of more than 300 tons. It has been established that the required relative thrust-to-weight ratio should be within . Defining parameters such as , and is the basis for the implementation of other modification changes in the heavy transport aircraft.
PENGOLAHAN AIR GAMBUT MENGGUNAKAN KOAGULAN ASAM JAWA DENGAN VARIABEL KONSENTRASI AIR GAMBUT DAN UKURAN KOAGULAN ASAM JAWA
Authors: Landang Yessika Kristina 
Published: August 2021

Air gambut di Kalimantan Tengah berwarna kecoklatan karena kandungan bahan organik yang tinggi sehingga menyebabkan air menjadi bau, warnanya keruh dan rasanya asam, sehingga tidak layak dipakai sebagai air bersih. Mengolah air gambut jadi air bersih dapat dilakukan dengan metode koagulasi-flokulasi menggunakan biji asam jawa sebagai koagulan. Tujuan penelitian ini yaitu menghitung efisiensi removal parameter warna, TDS, TSS, dan besi (Fe) pada air gambut memakai ukuran koagulan dan konsentrasi air gambut yang berbeda serta mengevaluasi hasil penelitian dikaitkan dengan baku mutu air bersih PERMENKES No.492 Tahun 2010. Pengolahan air dalam penelitian ini menggunakan sistem batch. Variabel konsentrasi air gambut dibagi menjadi 2 yaitu 100 % dan 50 %. Untuk optimasi proses ditambahkan kapur sebanyak 30 gram untuk sampel air 100 % dan 15 gram untuk sampel air 50 %. Pemakaian koagulan biji Asam Jawa berbentuk bubuk dengan variabel ukuran koagulan 100 mesh, 150 mesh dan 200 mesh. Hasil penelitian ini menunjukkan koagulan Asam Jawa dapat menurunkan kadar warna dari 2285 Pt-Co menjadi 11 Pt-Co dengan efisiensi removal sebesar 99 %. Sudah memenuhi baku mutu air bersih yaitu sebesar 15 Pt-Co. Menurunkan kadar TDS dari 370 mg/L menjadi 129 mg/L dengan efisiensi removal sebesar 52 %. Nilai TDS telah memenuhi baku mutu yaitu sebesar 500 mg/L. Menurunkan kadar TSS air gambut dari 1200 mg/L menjadi 400 mg/L dengan efisiensi removal sebesar 66 %, dan menurunkan kandungan besi (Fe) dari 1,8 mg/L menjadi 0,0026 mg/L dengan efisiensi removal sebesar 99 %. Nilai besi (Fe) telah memenuhi baku mutu yaitu sebesar 0,3 mg/L.
KOMBINASI CASCADE AERATOR DAN ADSORBSI ZEOLITE DALAM MENURUNKAN KADAR FE TERLARUT DI AIR SUMUR
Authors: Wibisono Farhan Septiari , Rahmanto Tuhu Agung 
Published: August 2021

Masalah yang sering dijumpai pada air sumur adalah tingginya kandungan zat besi (Fe). Penelitian ini bertujuan untuk mereduksi kandungan Fe terlarut pada air sumur dengan aerasi dan sistem adsorbsi. Aerasi yang digunakan adalah cascade aerator dengan menggunakan dua cascade aerator dengan dua variasi luas yang diberi tinggi 20 cm antar anak tangga. Media adsorbsi adalah zeolit dengan tinggi masing-masing 8 mesh. Pengambilan sampel dilakukan di salah satu sumur masyarakat di Kecamatan Sukodono di Sidoarjo. Penelitian dilakukan selama tiga hari dengan proses pengambilan sampel dilakukan pada bak penampung hasil aerator dan kedua adsorbsi. Hasil penelitian menunjukkan bahwa proses aerasi dengan cascade aerator mampu menurunkan kadar Fe hingga 74,58% dan 61,93%. Sedangkan proses adsorbsi dengan media zeolit mampu menurunkan kadar Fe sebesar 86,12% dan Mn sebesar 96,81%.
PENGELOLAAN DAUR ULANG SAMPAH PLASTIK DI KAWASAN WISATA PANTAI PANYURAN KABUPATEN TUBAN UNTUK MENINGKATKAN NILAI JUAL SAMPAH DENGAN PERAN SERTA MASYARAKAT
Authors: Kusumawati Maulita Mega , R. Naniek Ratni J.A. 
Published: August 2021

Pantai Panyuran adalah suatu tempat tujuan pariwisata yang sangat terkenal di daerah Tuban dengan rata-rata jumlah pengunjung 3 bulan terakhir yakni dari bulan Agustus - Oktober 2020 adalah 25.199 orang. Waktu penelitian dilakukan selama 14 hari di kawasan wisata pantai Panyuran dengan menggunakan metode pengambilan data yaitu metode Simple Random Sampling. Hasil penelitian yang didapatkan adalah dari 400 kg total timbulan sampah dan terpilah menjadi sampah kertas 25 kg, sampah organik 66 kg, non organik 10 kg, dan sampah plastic 101 kg. Untuk sampah plastik yang layak didaur ulang yakni sebesar 101 kg, dan sisanya 198 kg adalah sampah plastik yang tidak bisa lagi didaur ulang dan juga sampah selain sampah plastik akan diteruskan ke TPA.
PERENCANAAN JALUR PENGANGKUTAN SAMPAH KOTA BANGKALAN DENGAN MODEL DINAMIS
Authors: Ghefurulloh Abdul , Mirwan Mohammad 
Published: August 2021

Beberapa kota di Indonesia masih banyak mengalami permasalahan mengenai persampahan, khusunya Kota Bangkalan yang merupakan salah satu kabupaten di Pulau Madura. Dalam pengelolaan persampahannya, Kota Bangkalan memiliki 1 TPA dan 12 armada pengangkut sampah dengan timbulan sampah sebesar 270,58 m3/hari pada tahun 2019. Dinas terkait Kota Bangkalan berencana melakukan pembangunan TPA baru guna mengatasi permasalahan sampah yang terus meningkat tiap tahun. Penelitian ini bertujuan untuk merencanakan rute pengangkutan sampah menuju TPA baru dan memproyeksi kebutuhan ritasi serta jumlah armada pengangkutan untuk 10 tahun mendatang menggunakan model dinamis dengan bantuan software stella. Hasil penelitian menunjukkan bahwa pada tahun 2029 memiliki kebutuhan armada sebanyak 40 unit dan kebutuhan ritasi sebanyak 18 dengan total timbulan sampah sebesar 302,76 m3 perhari. Rute alternatif 2 mampu menghemat jarak tempuh 42,4 km/hari serta penghematan biaya sebesar Rp. 76.320,-/hari atau Rp. 2.289.600,-/bulan dan Rp. 27.475.200,-/tahun.
A Prognostic Signature Constructed by CTHRC1 and LRFN4 in Stomach Adenocarcinoma
Authors: Han Songling , Zhu Wei , Yang Weili , Guan Qijie , Chen Chao , He Qiang , Zhong Zhuoheng , Zhao Ruoke , Xiong Hangming , Han Haote , Li Yaohan , Sun Zijian , Hu Xingjiang , Tian Jingkui 
Published: August 2021

BackgroundStomach adenocarcinoma (STAD) is the most common histological type of stomach cancer, which causes a considerable number of deaths worldwide. This study aimed to identify its potential biomarkers with the notion of revealing the underlying molecular mechanisms.MethodsGene expression profile microarray data were downloaded from the Gene Expression Omnibus (GEO) database. The “limma” R package was used to screen the differentially expressed genes (DEGs) between STAD and matched normal tissues. The Database for Annotation, Visualization, and Integrated Discovery (DAVID) was used for function enrichment analyses of DEGs. The STAD dataset from The Cancer Genome Atlas (TCGA) database was used to identify a prognostic gene signature, which was verified in another STAD dataset from the GEO database. CIBERSORT algorithm was used to characterize the 22 human immune cell compositions. The expression of LRFN4 and CTHRC1 in tissues was determined by quantitative real-time PCR from the patients recruited to the present study.ResultsThree public datasets including 90 STAD patients and 43 healthy controls were analyzed, from which 44 genes were differentially expressed in all three datasets. These genes were implicated in biological processes including cell adhesion, wound healing, and extracellular matrix organization. Five out of 44 genes showed significant survival differences. Among them, CTHRC1 and LRFN4 were selected for construction of prognostic signature by univariate Cox regression and stepwise multivariate Cox regression in the TCGA-STAD dataset. The fidelity of the signature was evaluated in another independent dataset and showed a good classification effect. The infiltration levels of multiple immune cells between high-risk and low-risk groups had significant differences, as well as two immune checkpoints. TIM-3 and PD-L2 were highly correlated with the risk score. Multiple signaling pathways differed between the two groups of patients. At the same time, the expression level of LRFN4 and CTHRC1 in tissues analyzed by quantitative real-time PCR were consistent with the in silico findings.ConclusionThe present study constructed the prognostic signature by expression of CTHRC1 and LRFN4 for the first time via comprehensive bioinformatics analysis, which provided the potential therapeutic targets of STAD for clinical treatment.
Altered Fecal Microbiome and Metabolome in a Mouse Model of Choroidal Neovascularization
Authors: Li Yun , Cai Yuting , Huang Qian , Tan Wei , Li Bingyan , Zhou Haixiang , Wang Zicong , Zou Jingling , Ding Chun , Jiang Bing , Yoshida Shigeo , Zhou Yedi 
Published: August 2021

PurposeChoroidal neovascularization (CNV) is the defining feature of neovascular age-related macular degeneration (nAMD). Gut microbiota might be deeply involved in the pathogenesis of nAMD. This study aimed to reveal the roles of the gut microbiome and fecal metabolome in a mouse model of laser-induced CNV.MethodsThe feces of C57BL/6J mice with or without laser-induced CNV were collected. Multi-omics analyses, including 16S rRNA gene sequencing and untargeted metabolomics, were conducted to analyze the changes in the gut microbial composition and the fecal metabolomic profiles in CNV mice.ResultsThe gut microbiota was significantly altered in CNV mice. The abundance of Candidatus_Saccharimonas was significantly upregulated in the feces of CNV mice, while 16 genera, including Prevotellaceae_NK3B31_group, Candidatus_Soleaferrea, and Truepera, were significantly more abundant in the controls than in the CNV group. Fecal metabolomics identified 73 altered metabolites (including 52 strongly significantly altered metabolites) in CNV mice compared to control mice. Correlation analysis indicated significant correlations between the altered fecal metabolites and gut microbiota genera, such as Lachnospiraceae_UCG-001 and Candidatus_Saccharimonas. Moreover, KEGG analysis revealed six pathways associated with these altered metabolites, such as the ABC transporter, primary bile acid biosynthesis and steroid hormone biosynthesis pathways.ConclusionThe study identified an altered fecal microbiome and metabolome in a CNV mouse model. The altered microbes, metabolites and the involved pathways might be associated with the pathogenesis of nAMD.