bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Characteristics and Treatment Outcomes of Primary Malignant Melanoma of Esophagus: A Single Center Experience Running head: Outcomes of primary esophageal melanoma
Authors: Kim Tae-Se , Min Byung-Hoon , Min Yang Won , Lee Hyuk , Rhee Poong-Lyul , Kim Jae J. , Lee Jun Haeng 
Published: November 2021

Abstract
BackgroundPrimary malignant melanoma of esophagus (PMME) is an extremely rare disease with poor prognosis. The aim of this study was to determine the clinical characteristics and treatment outcomes of patients with PMME. MethodsWe retrospectively reviewed 17 patients diagnosed with PMME in Samsung Medical Center between 2000 and 2020. Clinical characteristics and survival outcomes were analyzed. Results15 patients (88.2%) were male and the most common presenting symptom was dysphagia (9/17, 52.9%). On endoscopy, tumors were mass-forming in 15 patients (88.2%) and diffusely infiltrative in two patients (11.8%). Lesions were melanotic in 13 patients (76.5%) and amelanotic in four patients (23.5%). The most common anatomic location of tumor was lower esophagus (11/17, 64.7%). The disease was metastatic at the time of diagnosis in four patients (23.5%). As for treatment, 10 patients (58.8%) underwent surgery. In all 17 patients, the median overall survival was 10 months. In surgically treated patients, all patients experienced recurrence and the median disease-free survival was 4 months. There was no statistical difference in overall survival between patients with or without surgery. Patients with diffusely infiltrative tumor morphology had better overall survival compared to those with mass-forming tumor morphology (P = 0.048). Two patients who received immunotherapy as the first-line treatment without surgery showed overall survival of 34 and 18 months, respectively. ConclusionsAs radical resection for patients with PMME does not guarantee favorable treatment outcomes, novel treatment strategy is required. Further large-scale studies are warranted to determine the efficacy of immunotherapy for patients with PMME.
Optimization of CNC CO2 Laser Cutting Process Parameters on Acrylic Cutting Using Taguchi Grey Relational Analysis and Response Surface Methodology
Authors: Oktatian Eldinar , Rosyidi Cucuk Nur , Pujiyanto Eko 
Published: November 2021

Abstract
Polymethylmethacrylate (acrylic) has some important characteristics such as light weight, impact-resistant, and high durability. In a manufacturing industry, acrylic has been widely used as the basic material for billboard products, decorative lights, canopies, and room decorations. This research aims at determining the optimal process parameters of the laser cutting process. The experiment was conducted using multi-response Taguchi method involving four responses, namely processing time, dimensional accuracy, surface roughness, and carbon emissions. The Taguchi method is used to determine the Signal to Noise (SNR) for each response. The Grey Relational Analysis (GRA) method is performed by calculating the normalized weight of SNR for each response to determine the optimal setting level of each factor applied in the experiment. The Response Surface Methodology (RSM) was applied to determine the mathematical model based on the results of the experiment to allow the multi-objective optimization and determine the exact value of optimal process parameters which simultaneously compromise all the responses. Based on the results of the experiment, the optimal process parameters are 65% of the laser power, 4 mm/s of the cutting speed, and 4 mm of nozzle distance. Whereas from the results multi-objective optimization, the optimal process parameters are 75% of laser power, 5.9 mm/s of cutting speed, and 3mm of nozzle distance.
Host--Parasitoid Dynamics and Climate-Driven Range Shifts
Authors: Marcinko Kelsey 
Published: November 2021

Abstract
Climate change has created new and evolving environmental conditions, impacting all species, including hosts and parasitoids. I therefore present integrodifference equation (IDE) models of host--parasitoid systems to model population dynamics in the context of climate-driven shifts in habitats. I describe and analyze two IDE models of host--parasitoid systems to determine criteria for coexistence of the host and parasitoid. Specifically, I determine the critical habitat speed, beyond which the parasitoid cannot survive. By comparing the results from two IDE models, I investigate the impacts of assumptions that reduce the system to a single-species model. I also compare critical speeds predicted by a spatially-implicit difference-equation model with critical speeds determined from numerical simulations of the IDE system. The spatially-implicit model uses approximations for the dominant eigenvalue of an integral operator. The classic methods to approximate the dominant eigenvalue for IDE systems do not perform well for asymmetric kernels, including those that are present in shifting-habitat IDE models. Therefore, I compare several methods for approximating dominant eigenvalues and ultimately conclude that geometric symmetrization and iterated geometric symmetrization give the best estimates of the parasitoid critical speed.
Diabetic Ketoacidosis (DKA) Induced Cerebral Edema Complicating Small Chronic Subdural Hematoma/Hygroma/ at Zewuditu Memorial Hospital: A Case Report
Authors: Shiferaw Mestet Yibeltal , T/Mariam Tsegazeab Laeke , Aklilu Abenezer Tirsit , Akililu Yemisirach Bizuneh , Worku Bethelhem Yishak 
Published: November 2021

Abstract
BackgroundWhile both DKA & CSDH/subdural hygroma/ are known to cause significant morbidity and mortality, there is no a study that shows the role & effect of DKA on CSDH/subdural hygroma/ & vice versa to authors’ best knowledge; hence this work will show how important relation does exist between DKA & CSDH/ hygroma.Case summaryThis study highlights the diagnostic & management challenges seen for a case of a 44 years old female black Ethiopian woman admitted with a diagnosis of newly diagnosed type 1 DM with DKA + small CSDH/subdural hygroma/ after she presented with sever global headache and a 3 month history of lost to her work. She needed burrhole & evacuation for complete clinical improvement besides DKA’s medical treatment.ConclusionDKA induced cerebral edema on the CSDH/subdural hematoma/ can have a role in altering any of the parameters (except the thickness of CSDH) for surgical indication of patients with a diagnosis of both CSDH +DM with DKA. Hence, the treating physicians should be vigilant of different parameters that suggests tight brain &/ cerebral edema (including midline shift, the status of cisterns, fissures & sulci) and should not be deceived of the thickness of the CSDH/subdural hygroma/alone; especially when there is a disproportionately tight brain for the degree of collection. Whether DKA induced cerebral edema causes a subdural hygroma is unknown and needs further study.
The Fire Resistance Performance of Concrete Columns with Different Compressive Strength
Authors: Atea Rafid Saeed 
Published: November 2021

Abstract
Four full concrete columns have been created Tested below high temperature for The fire resistance of concrete elements in concrete with particular compressive strengths. The standard concrete with compressive strength values of C25 were made of one of the four specimens, while the rest were made of C35, C60 and C75 respectively, respectively. During simulation of Within the laboratory furnace, the same For the specimens, axial forces were applied. Many experimental outcomes parameters were evaluated in contrast, including temperature changes, Vertical moving, side deflection, fire resistance and Failed properties of the specimen. The results have shown a rise in the compressive strength of the concrete for the concrete columns from the outside up to the inside of the column. Of columns of the the same cross section of the lower compressive forces of concrete display better fire resistance efficiency with the same initial axial strength ratio. The C35, C60 and C75 columns' fire resistance is higher than standard concrete columns. The initial and secant rigidity of the columns of Reinforced concrete ( RC) has also The percentage decreased dramatically after fire exposure and the temperature increased from 25 to 750 ° C.
Integrated Interpretation of pXRF Data on Ancient Nephrite Artifacts Excavated from Tomb No.1 in Yuehe Town, Henan Province, China
Authors: Chen Dian , Yang Yimin , Qiao Baotong , Li Jingpu , Luo Wugan 
Published: November 2021

Abstract
Previous studies of ancient jade using portable X-ray fluorescence (pXRF) have mostly focused on mineral identification, alteration status and provenance determination. It is usually used as an auxiliary instrument for spectroscopic detection with finer resolution. However, there is no substitute for the efficiency and stability of pXRF in-situ non-destructive analysis, which is less affected by the test environment. The scale of the data from the pXRF analysis did not allow for a more in-depth interpretation of ancient jade in the past. In this study, pXRF has been carried out for a total of 112 pieces of nephrite artifacts unearthed from the Yuehe tomb No.1 in Nanyang City, Henan Province, Central China. Certain patterns become clearer as the size of the data increases. The coefficient of variation, cluster analysis and correlation analysis can be used to separate elements into different assemblages, revealing whether the elements are from the primary and impurity minerals of nephrite itself, from the burial microenvironment in the soil, or even from other specific sources. In addition, most of the secondary whitening occurring in the batch of nephrite are accompanied by an increase in Ca content, confirming the previously refuted theory of calcification. More importantly, the principal component analysis of the twin nephrite artifacts suggests visually indistinguishable elemental changes caused by secondary changes, which may lead to misjudgment of ancient nephrite provenance using elemental data.
Health Care Providers’ Perspectives on Providing End-Of-Life Psychiatric Care Between Cardiovascular and Oncological Hospitals: A Cross-Sectional Questionnaire Survey
Authors: Ichikura Kanako , Matsuoka Shiho , Chiba Hiroki , Ishida Hina , Fukase Yuko , Murase Hanako , Tagaya Hirokuni , Takeuchi Takashi , Matsushima Eisuke 
Published: November 2021

Abstract
Purpose
Psychological distress is a serious problem for patients with heart disease or cancer at the end of life. The aim of this study was to compare the barriers to providing end-of-life psychiatric care in cardiovascular compared to oncological settings.
Methods
In this cross-sectional questionnaire survey conducted in Japan, we mailed questionnaires to physicians and nurses in 347 oncological and 427 cardiovascular hospitals in March 2018 to assess health care providers’ perspectives. First, we applied the Palliative Care Difficulties Scale and assessed end-of-life psychiatric care difficulties. Second, we asked about barriers to providing end-of-life psychiatric care in free description.
Results
A total of 224 oncological and 213 cardiovascular hospitals responded to the questionnaires. The mean scores of palliative and end-of-life psychiatric care difficulties showed no significant differences between oncological and cardiovascular hospitals. Eight barriers to providing end-of-life psychiatric care were identified and were based on patients’ personal, interfamilial, clinicians’ personal, clinician-patient communication, end-of-life care, psychiatric care, systematic or environmental, and disease-specific problems. In addition, health care providers in cardiovascular hospitals were found to have a significantly higher rate of disease-specific issues compared with oncological hospitals.
Conclusion
Both oncological and cardiovascular physicians and nurses have similar difficulties in providing end-of-life psychiatric care. However, health care providers of cardiovascular hospitals particularly experience heart disease-specific problems, such as unpredictability of prognosis or insufficiency of guideline development.
Hippocampal Activated Microglia May Contribute to Blood-brain Barrier Impairment and Cognitive Dysfunction in Post-traumatic Stress Disorder-like Rats
Authors: Ni Kun , Zhu Jixiang , Xu Xuan , Liu Yue , Yang Shuai , Huang Yulin , Xu Rui , Jiang Li , Zhang Juan , Zhang Wei , Ma Zhengliang 
Published: November 2021

Abstract
Post-traumatic stress disorder (PTSD) associated cognitive dysfunction significantly disturbs patients’ quality of life and will-to-live. However, its underlying mechanism is as yet unknown. Recent researches indicate blood-brain barrier (BBB) breakdown is responsible for early cognitive dysfunction. Microglia might participate in remodeling of BBB-associated tight junction and regulating BBB integrity. Nevertheless, it is unclear whether microglia activation and BBB injury involve in PTSD-associated cognitive dysfunction. Hence, we established an animal model of PTSD, single prolonged stress (SPS) and investigated permeability changes in the hippocampus, and further explored the effects of microglia on BBB remodeling. The Y maze was used to assess the changes of cognitive function. The sodium fluorescein (NaFlu) assay and western blotting analysis were employed to detect BBB integrity changes. Minocycline was administrated to inhibit microglial activation. Immunofluorescence stains were used to assess the activation states in microglia. The results showed that SPS exposed rats exhibited poorer cognitive performance, higher passage of NaFlu, and lower expression of tight junction proteins (occludin and claudin 5) in the hippocampus on the day after SPS, but no difference on the 7th day. Inhibition of microglial activation by minocycline attenuated poor cognitive performance and BBB impairment including the extravasation of NaFlu and protein levels of the tight junction. Taken together, the present study indicates that BBB impairment may underlie the shared pathological basis of PTSD and cognitive dysfunction. Microglial activation may involve in BBB remodeling at the early stage of SPS.
Left Ventricular Systolic Motion Pattern Differs Among Patients With Left Bundle Branch Block Patterns
Authors: Chen Yan , Zhang Yanjuan , Xu Di , Chen Chun , Miao Changqing , Tang Huan , Ge Beibei , Shen Yan , Yao Jing 
Published: November 2021

Abstract
Purpose:The study aimed to investigate left ventricular (LV) motion pattern in patients with LBBB patterns including patients with pacemaker rhythm (PM), type B Wolff-Parkinson-White syndrome (B-WPW), premature ventricular complexes originating from the right ventricular outflow tract (RVOT-PVC), and complete left bundle branch block (CLBBB).Methods: Two-dimensional speckle tracking was used to evaluate peak value and time to peak value of the LV twist, LV apex rotation, and LV base rotation in patients with PM, B-WPW, RVOT-PVC, and CLBBB with normal LV ejection fraction, and in age-matched control subjects.Results: The LV motion patterns were altered in all patients compared to the control groups. Patients with PM and CLBBB had a similar LV motion pattern with a reduced peak value of LV apex rotation and LV twist. Patients with B-WPW demonstrated the opposite trend in the reduction of LV rotation peak value, which was more dominant in the basal layer. The most impairment in the LV twist/rotation peak value was identified in patients with RVOT-PVC. Compared to the control group, the apical-basal rotation delay was prolonged in patients with CLBBB, followed by those with B-WPW, RVAP, and RVOT-PVC.Conclusion: The LV motion patterns were different among patients with different patterns of LBBB. CLBBB and PM demonstrated a reduction in LV twist/rotation that was pronounced in the apical layer, B-WPW showed a reduction in the basal layer, and RVOT-PVC in both layers. CLBBB had the most pronounced LV apical-basal rotation dyssynchrony.
Early vascular healing of ultra-thin strut polymer-free sirolimus-eluting stents in acute coronary syndrome: USUI-ACS study
Authors: Matsuhiro Yutaka , Egami Yasuyuki , Okamoto Naotaka , Kusuda Masaya , Sakio Takashige , Nohara Hiroaki , Sugae Hiroki , Kawanami Shodai , Kawamura Akito , Ukita Kohei , Nakamura Hitoshi , Yasumoto Koji , Tsuda Masaki , Matsunaga Yasuharu Lee , Yano Masamichi , Nishino Masami , Tanouchi Jun 
Published: November 2021

Abstract
Purpose:Ultra-thin strut polymer-free sirolimus eluting stent (UPF-SES) have two novel characteristics, ultra-thin strut and polymer-free coating, which have the potential to achieve early re-endotherialization. However, a little is known whether early vascular healing of UPF-SES can be achieved in patients with acute coronary syndrome (ACS).The aim of this study was to evaluate the vascular healing after an implantation of UPF-SES in patients with ACS using optical coherence tomography (OCT) at 3 months after the stent implantation. Methods:From September 2020 and January 2021, a total of 31 consecutive patients presenting with ACS who underwent OCT examinations at the initial percutaneous coronary intervention (PCI) and 3-month follow-up were enrolled in the USUI-ACS study. The endpoints of this study were neointimal strut coverage, malapposition, and mean neointimal hyperplasia (NIH) thickness at 3-month follow-up.Results:Over a mean follow-up of 91 days after the initial PCI, the follow-up OCT was examined. The median percentage of covered struts was 98.4% and malapposed struts 0%, and the mean NIH thickness was 60μm.Conclusions:UPF-SES exhibited an excellent early vascular healing at 3-months in patients with ACS.
Metastatic Signet-Ring-Cell Carcinoma of Bladder From Breast Invasive Lobular Carcinoma Found By CT: A Case Report And Literature Review
Authors: Jin Xiaoxiang , Tang Haibin , Chen Hualin , Chen Gang 
Published: November 2021

Abstract
Background: Secondary bladder tumors are relatively rare in all bladder tumors, while bladder metastases from breast cancer were rarely reported. And interestingly, signet-ring differentiation may appear in metastases from a breast invasive lobular carcinoma regardless of whether or not the primary breast tumor had signet-ring cells, which may cause diagnostic uncertainty.Case presentation: We report a case of a 55-year-old female patient with diffuse bladder thickening as the chief complaint. There was no special clinical manifestation, while cystoscopy showed multiple scattered red protuberances and the biopsy suggested signet-ring-cell carcinoma. Result of gastroscopy suggested poorly differentiated adenocarcinoma with signed-ring cells. Considering the patient's previous history of invasive lobular carcinoma of the breast, chronic myeloid leukemia and metastatic endometrial carcinoma from the breast, we performed the immunohistochemistry and the results indicated that signet-ring-cell carcinomas of the stomach and bladder originated from the breast invasive lobular carcinoma. we performed Positron Emission Tomography/Computed Tomography (PET/CT) and the results showed that there were multiple bone metastases already.Conclusion: This is the first English case report of invasive lobular carcinoma of breast metastasizing to uterus, stomach, bladder and bones with multiple signet-ring-cell variations. We also focus on the Computed Tomography (CT), immunohistochemistry (IHC) and cystoscopy findings and share the clinical diagnosis ideas summarized by this case.
Elimination of Interionic Hydrogen Bonding in The Imidazolium-Based Ionic Liquids
Authors: Chaban Vitaly 
Published: November 2021

Abstract
Hydrogen bonding is a phenomenon of paramount importance in room-temperature ionic liquids. The presence or absence of the hydrogen bond drastically alternates self-diffusion, shear viscosity, phase transition points, and other key properties of a pure substance. For certain applications, the presence of cation-anion hydrogen bonding is undesirable. In the present paper, we investigate perspectives of removing the hydrogen...fluorine interionic attraction in the imidazolium borates, the strongest non-covalent interaction in this type of system. Chemical modification of the tetrafluoroborate anion not only eliminates hydrogen bonding but also changes the most thermodynamically preferable orientation of the cation in the vicinity of the anion. Although the most acidic hydrogen atom of the imidazole ring remains the paramount electrophilic center of the cation, it does not engender a strong electrostatically driven coordination pattern with the properly modified anions. The reported new physical insights help compose more robust ionic liquids and tune solvation properties of the imidazolium-based RTILs.
14-3-3 Gene of Zostera Japonica ZjGRF1 Participates in Gibberellin Signaling Pathway
Authors: Chen Siting , Qiu Guanglong 
Published: November 2021

Abstract
Background Zostera japonica (Z. japonica) is a unique seagrass species in Asia, which has important ecological value. Gibberellin is an important plant hormone, which plays an important role in the regulation of plant growth and development, including seed longevity, seed germination, anti-aging, hypocotyl elongation, leaf development, reproductive organ development and abiotic stress. However, the role of 14-3-3 gene of Z. japonica in GA signaling pathway is still unclear. Methods and results Here, we found that the gibberellin content of Arabidopsis overexpressing ZjGRF1, 14-3-3 gene of Z. japonica, is lower than that of wild type (WT), and the expression of gibberellin synthesis genes is lower than that of WT. The expression level of gibberellin receptors in transgenic ZjGRF1 Arabidopsis was lower than that in WT. The expression level of GA response genes EXP8 in transgenic ZjGRF1 Arabidopsis was lower than that in WT, and the expression levels of PRE1, PRE5 and SCL3 were higher than that in WT. Transgenic ZjGRF1 Arabidopsis is insensitive to paclobutrazol, an inhibitor of gibberellin synthesis. The expression level of flowering regulatory genes in transgenic ZjGRF1 Arabidopsis was lower than that in WT. Conclusion This is the first report on the function of 14-3-3 gene family in seagrass. Our findings can be further utilized in future studies on regulation of 14-3-3 gene on plant development.