bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repurposing the atypical antidepressant trazodone for atherosclerotic cardiovascular disease
Authors: Johnson Kipp , Narula Jagat , Glicksberg Benjamin , Shameer Khader , Chaudhry Farhan , Yahi Alexandre , Khan Nayaab , Amadori Letizia , Krittanawong Chayakrit , Readhead Ben , Hagan Ross , Becker Christine , Chaudhry Fayzan , Divaraniya Aparna , Smith Milo , Baber Usman , Li Li , McCauley Benjamin , Nadkarni Girish , Pak Koon Yan , Gray Brian , Kaji Deepak , Percha Bethany , Vengrenyuk Yuliya , Suleman Javed , Tatonetti Nicholas , Butte Atul , Petrov Artiom , Arbustini Eloisa , Giannarelli Chiara , Narula Navneet , Strauss William , Dudley Joel , Kini Annapoorna 
Published: June 2021

Abstract
Background. Current lipid-lowering drugs often leave significant residual risk for adverse outcomes. Identification of previously approved drugs for new indications, drug repurposing, may provide a cost effective alternative to de novo drug developing.Objectives. We combined clinical, transcriptomic, computational, and experimental strategies to explore lipid-lowering and plaque-stabilizing effects of atypical antidepressant trazodone.Methods. First, a connectivity mapping strategy was used to match rosuvastatin gene expression signature derived from a clinical trial of 85 patients with to the expression patterns of 1,309 different small molecules to discover a similarity between the rosuvastatin and trazodone gene expression signatures. Then, we assessed the lipid-lowering ability of trazodone in vitro using HepG2 cells and in vivo using molecular imaging of rabbit atherosclerotic lesions. In addition, we analyzed electronic medical records of patients from three large medical centers who had a prescription for trazodone and lipid laboratory measurements available.Results. Trazodone significantly reduced cholesterol levels in the HepG2 human hepatocyte model, decreased atherosclerotic plaque burden in a rabbit model and lowered low-density lipoprotein (LDL) cholesterol levels in patients.Conclusion. Our results indicate that trazodone may be a promising candidate for adjunctive lipid lowering therapy. It may provide significant benefits to patients with hyperlipidemia, including lipid level reduction and formation of a more favorable atherosclerotic plaque morphology. Patients diagnosed with major depressive disorder requiring better lipid control would benefit the most from the for adjunctive lipid lowering therapy.
Design and Analysis of Patch Antenna for C, X, Ku Band Applications
Authors: R Shantha Selvakumari , P Vishnoo Priyaa 
Published: June 2021

Abstract
This paper presents the design and simulation of patch antenna loaded with metamaterial called Complementary Split Ring Resonator (CSRR) with increased gain and bandwidth suitable for wireless applications such as satellite, TV and radar applications. FR4 substrate with dielectric constant (εr ) of 4.4 is used. The radiating patch consists of CSRR structure fed by microstrip line to achieve triple(C, X, Ku ) band characteristics. The proposed antenna is designed and simulated using Ansys High Frequency Structural Simulator (HFSS). The proposed antenna with 4 rings having a resonant frequency of 7.662, 9.8510, 10.9455, 11.8410, 12.7365 and 13.7315GHz and the bandwidth of 230, 1090, 640, 580, 620 and 2000MHz respectively. The proposed antenna with 6 rings also having a resonant frequency of 7.7615, 9.9525, 11.0450, 11.9405 and13.7315GHz and bandwidth of 160, 1130, 490, 1360 and 1480MHz are achieved. The proposed antenna is analyzed in terms of return loss, VSWR, gain and bandwidth. The electric field and surface current distribution were observed for the proposed antenna having 6 rings.
A Lossless Distributed Data Compression and Aggregation Approach for Low Resources Wireless Sensors Networks
Authors: FUTE Elie TAGNE , KAMDJOU Hugues Marie , AMRAOUI Adnen EL , NZEUKOU Armand 
Published: June 2021

Abstract
Wireless Sensor Networks (WSN) have been as useful and beneficial as resource-constrained distributed event-based system for several scenarios.Yet, in WSN, optimization oflimited resources (energy, computing memory, bandwidth and storage) during data collection and communication process is a major challenge. Most of energy consumption (as much as 80%) for standard WSN applications lies in the radio module where receiving and sending packets are necessary to communicate between stations.This paper proposes an approach to achieve optimal sensor resources by data compression and aggregation regarding integrity of raw data.Data aggregation discarded a certain sensing data packet, which leads to low data-rate communication and low likelihood of packet collisions on the wireless medium. Data compression reduces a redundancy in aggregated data, which leads to save storage and sending only one small data stream in the bandwidthof communication.The performance of the proposed approach is qualified using experimental simulation on OMNeT++/Castalia. Theperformance metricswere evaluated in terms of Compression Ratio (CR), data Aggregation Rate (AR), Peak Signal-to-Noise Ratio (PSNR) and Mean Square Error (MSE) and Energy Consumption (EC).The obtained resultshave significantly increased the network lifetime.Moreover, the integrity (quality) of the raw data is guaranteed.
New Electronically/Resistively Tunable Floating Emulators to Realize Memristor and Inverse Memristor
Authors: Bhardwaj Kapil , Srivast Mayank 
Published: June 2021

Abstract
This article presents the architectures of two emulator circuits, which realize the behaviour of a floating memristor and inverse memristor respectively. Both the presented emulator circuits are based on modified Voltage Differencing Current Conveyor (MVDCC) and grounded passive elements only. The feature of Electronic/Resistance tunability is found in both the emulator circuits. Furthermore, no employment of any external multiplier circuitry can be viewed as an important advantage of the proposed emulators. Also, the utility of the inverse memristor has also been discussed in theoretical discussions. The simulations have been performed to verify the working of all the presented emulator circuits, under PSPICE environment. Moreover, these MVDCC based emulators are also designed using commercially available ICs, LM13700 and AD844.
Guiding Effect of Soft Tectonic Coal on Coal and Gas Outburst and its Experimental Study
Authors: Tu Qingyi , Xue Sheng , Cheng Yuanping , Zhang Wei , Shi Gaofeng , Zhang Guisheng 
Published: June 2021

Abstract
Soft tectonic coal commonly exists in coal and gas outburst zones. The physical simulation experiment was carried out to reproduce the influences of soft coal area on the outburst, and the guiding action mechanism of soft tectonic coal on the outburst was investigated. This study concludes that the amount of outburst coal in the experiments of group with local existence of soft coal area are relatively lower. The outburst coal amount (3.8035 kg) and relative outburst intensity (21.02%) in the GR5# experiment were both lower than that in the GN6# experiment of control group. However, the outburst coal in the experiments of group with local existence of soft coal area could be commonly migrated to a long distance, the maximum throwing distances in the three experiments were all over 16.73 m, reaching as high as 20.10 m. Under the gas pressure of 0.30 MPa in the group with local existence of soft coal area, the outburst coal amount (2.7355 kg) was smaller than the amount (2.803 kg) of pulverized coal filled, and the 2.0 cm coal pillar experiences failure only nearby the outburst mouth. As the gas pressure increases, the failure degree of the coal pillar becomes higher and higher until complete failure. The outburst development sequence is changed due to the existence of the soft tectonic soft area. Once the sealing conditions are destructed, the outburst firstly develops in the soft tectonic coal area. Nevertheless, sufficient energy is supplied to transport the coal mass in the soft tectonic coal area to a farther distance, while the residual outburst energy can just result in the outburst of a small quantity of coal masses in the normal area. This research will be of great scientific significance for explaining the soft tectonic coal-induced change of outburst starting and development sequence.
A Trade-Off Analysis of Adaptive and Non-Adaptive Future Optimized Rule Curves Based on Simulation Algorithm
Authors: Moghaddasi Mahnoosh , Anvari Sedigheh , Akhondi Najmeh 
Published: June 2021

Abstract
This study aims to investigate the performance of Zarrineh Rud reservoir by implementing strategies for adaptation to climate change. Using sequent peak algorithm (SPA), the rule curve were simulated. Then, the optimal rule curve was procured through GA-SPA, aiming to minimize the water shortage. The future data were downscaled using SDSM based on CanEsm2 model and under RCP2.6 and RCP8.5. Finally, in view of environmental demand, reservoir performance indices were calculated for both non-adaptive and adaptive policies during all future periods (2020–2076). Results showed simulation with the static hedging rules managed to significantly reduce the average vulnerability index (by 60%) compared to no hedging, while the dynamic hedging rules outperformed static hedging rules only by 9%. Therefore, considering the insignificant improvement in reservoir performance using dynamic rules and their complexity, static hedging rules are recommended as the better option for adaptation during climate change.
FERMT3 Mediates Cigarette Smoke-induced Epithelial-mesenchymal Transition Through Wnt/β-Catenin Signaling
Authors: Su Xiaoshan , Chen Junjie , Lin Xiaoping , Chen Xiaoyang , Zhu Zhixing , Wu Weijing , Lin Hai , Wang Jianming , Ye Xiangjia , Zeng Yiming 
Published: June 2021

Abstract
Background: Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD) and lung cancer. Epithelial-mesenchymal transition (EMT) is an essential pathophysiological process in COPD and plays an important role in airway remodeling, fibrosis, and malignant transformation of COPD. Previous studies have indicated FERMT3 is downregulated and plays a tumor suppressive role in lung cancer. However, the role of FERMT3 in COPD, including EMT, has not yet been investigated. Methods: The present study aimed to explore the potential role of FERMT3 in COPD and its underlying molecular mechanisms. Two GEO datasets were combined to identify FERMT3 involved in COPD. The expression of FERMT3 was identified in COPD from two GEO datasets. We then established EMT animal models and cell models through cigarette smoke (CS) or cigarette smoke extract (CSE) exposure to detect the expression of FERMT3 and EMT markers. RT-PCR, western blot, immunohistochemical, cell migration, and cell cycle were employed to investigate the potential regulatory effect of FERMT3 in CSE-induced EMT. Results: Based on the GEO dataset analysis, the expression of FERMT3 was downregulated in COPD-smoker bronchoalveolar lavage fluid than that in Non-smoker. Cigarette smoke exposure reduced the FERMT3 expression and induces EMT both in vivo and in vitro. The results showed that overexpression of FERMT3 could inhibit EMT induced by CSE in A549 cells. Furthermore, the CSE-induced cell migration and cell cycle progression were reversed by FERMT3 overexpression. Mechanistically, our study showed that overexpression of FERMT3 inhibited CSE-induced EMT through the Wnt/β-catenin signaling. Conclusions: In summary, these data suggest FERMT3 regulates cigarette smoke-induced epithelial-mesenchymal transition through Wnt/β-Catenin signaling. These findings indicated that FERMT3 was correlated with the development of COPD and may serve as a potential target for both COPD and lung cancer.
Analysis of Risk Factors for Changes in The Doppler Echocardiographic Indexes of Patients With Gout
Authors: Dang Wantai , Luo Danling , Luo Hui , Hu Jing , Xu Xiaohui , Zhou Jingguo , Liu Jian 
Published: June 2021

Abstract
Objective: The analysis of risk factors for changes in the Doppler echocardiographic indexes of patients with gout with different serum uric acid (SUA) levels were explored to provide clinical evidence for the early diagnosis and treatment of abnormal heart function in this patients.Methods: We obtained information of 227 patients with primary gout (intermittent period), the left ventricular structure and functional index were measured using echocardiography and multivariate logistics regression was used to analyze the risk factors related to changes in heart function in patients with gout.Results: Logistic regression analysis showed that the course of disease and cystatin C (Cys-C) were risk factors for the increase of left atrial volume index (LAVI) (OR=1.14, 105.47; 95% CI, 1.01-1.28, 1.18-9468.03). Age, body mass index (BMI), course of disease, and diabetes were risk factors for the increase of the ratio of diastolic peak early transmission flow velocity to peak early diastolic mitral annulus velocity (E/Em) (OR=1.04, 1.17, 1.14, 4.82; 95% CI, 1.01-1.08, 1.03-1.33, 1.02-1.27, 1.07-21.71). However, the percentage of neutrophils percentage (NE%) and lymphocytes percentage (LY%) might reduce the risk of left ventricular wall thickening, whereas HGB might reduce the risk of increasing E/Em (OR=0.80, 0.75, 0.94; 95% CI, 0.66-0.96, 0.60-0.93, 0.89-1.00).Conclusion: Our findings suggest that BMI, course of disease, diabetes, and Cys-C are risk factors for decreased left ventricular function. Furthermore, HGB, NE%, and LY% appear to have a weak protective effect for the remodeling of left ventricular structure and function.
Downregulation of GJB2 and SLC26A4 Genes Induced by Noise Exposure is Associated with Cochlear Damage
Authors: Garmaroudi Amir Abbasi , Khadem Monireh , Hotkani Maryam Mirzaei , Mozaffari Sajjad , Esmaeilpoor MohammadReza Monazzam , Kazemirad Elham 
Published: June 2021

Abstract
Noise can change the pattern of gene expression inducing sensorineural hearing impairment. There is no investigation on effects of noise frequency on the expression of GJB2 and SLC26A4 genes involved in congenital hearing impairment in cochlear tissue. This study investigated impacts of white and purple noise on gene expression and pathologic changes of cochlear tissue. In this study, 32 adult male Westar rats were selected and divided into experimental groups WN (animals exposed to white noise with a frequency range of 100-20000 Hz), PN (animals exposed to purple noise with a frequency range of 4-20 kHz) and control groups. All experimental groups were exposed to a sound pressure level of 118-120 dB for 8 hours per day. Cochlear tissue sampling was performed for tissue pathology studies, also RNA was extracted at 1 hour & 1 week after cessation of noise exposure. The results showed that Both white and purple noises caused permanent damage to the cortical, estrosilica systems of hair cells and ganglion of the hearing nerve. GJB2 and SLC26A4 were downregulated in both groups exposed with white and purple noise. However, differences are notably more significant in 1 weak post-exposure than 1 hour. Our Findings suggest GJB2 and SLC26A4 can be considered as biomarkers of response to noise frequency which is associated with the pathological response of cochlear tissue, leading to sensorineural hearing impairment. It would be suggested the demand for a more conventional approach to assessment of noise-induced hearing loss and subsequently the practice of hearing protection programs.
Fine Mapping and Identification of the Lobed-Leaf Gene in Radish (Raphanus Sativus L.)
Authors: li xuewei , Guo Chaocheng , Song Yao , Zhang Xiaokang , Xiong Qiufang , Liu Kede 
Published: June 2021

Abstract
Leaf shape is one of the important factors affecting the yield and quality of radish (Raphanus sativus L.). In this study, an F2 population obtained from the cross of the lobed-leaf cultivar J4 with the serrated-leaf cultivar WA was used for genetic analysis and gene mapping of the lobed-leaf trait. The lobed-leaf trait is controlled by a single dominant nuclear gene, and dominant over the serrated-leaf trait. Through bulked segregant analysis (BSA) and genotyping by sequencing (GBS), the lobed-leaf gene was initially mapped to the genomic region from 0.66 Mb to 8.19 Mb on chromosome R7. By using nine insertion/deletion (INDEL) markers, the gene was further narrowed down to a 1.53 Mb region. The comparative analysis of the collinear region between Raphanus sativus and Brassica napus identified Rs390250, an HD-Zip I transcription factor as the most probable candidate gene. Phylogenetic analysis supported that Rs390250 is an RCO (REDUCED COMPLEXITY) orthologous gene, and the single nucleotide variation (C425T) of Rs390250 which caused an amino acid substitution from serine (S) to lysine (L) in conserved leucine zipper domain, may destroy its DNA-binding function and be supposed to response for the morphological variation.
Strengthening the Construction of Pathology Department of Chinese Primary Hospitals is an Urgent Task
Authors: Chen Ke , meng xiangling , Wang Zhengguang 
Published: June 2021

Abstract
Background: pseudomyxoma peritonei(PMP) is a rare disease, the incidence of occult, mainly occurs in the appendix, ovary, etc., generally speaking, the progress is slow, through imaging diagnosis is more difficult, and the symptoms are not typical, often found in abdominal exploration, the treatment effect is relatively poor. Because PMP is often secondary to appendectomy, it is particularly important to make a careful pathological examination of the specimen after appendectomy. Case presentation: This case is a middle-aged and elderly man. Seven years after appendectomy, the specimen was confirmed as PMP by pathology after laparoscopic exploration. Later, the specimen 7 years ago was reexamined and pathological examination showed that the tumor was composed of mucinous cells. Conclusions: This puts forward higher requirements for the construction of pathology department in China's primary hospitals.
C-Kit+ Cells Can Modulate Asthmatic Condition via Differentiation Into Pneumocyte-Like Cells and Alteration of Inflammatory Responses via ERK/NF-κB Pathway
Authors: Mirershadi Fatemeh , Ahmadi Mahdi , Rahbarghazi Reza , Heiran Hossein , Keyhanmanesh Rana 
Published: June 2021

Abstract
Background

The exact role of the progenitor cell types in the dynamic healing of asthmatic lungs is lacking. This investigation was proposed to evaluate the effect of intra-tracheally administered rat bone marrow-derived c-kit⁺ cells on ovalbumin-induced sensitized male rats.
Methods

Forty rats were randomly divided into 4 groups; healthy rats received phosphate-buffered saline (PBS) (C); sensitized rats received PBS (S); PBS containing C-kitˉ cells (S + C-kit−); and PBS containing C-kit⁺ cells (S + C-kit⁺). After two weeks, circulatory CD4⁺/CD8⁺ T-cell counts and pulmonary ERK/NF-κB signaling pathway as well as the probability of cellular differentiation were assessed.
Results

The results showed that transplanted C-Kit+ cells were engrafted into pulmonary tissue and differentiated into epithelial cells. C-Kit+ cells could increase the number of CD4+ cells in comparison with S group (p < 0.001); however, diminished the level of CD8+ cells (p < 0.01). Moreover, data showed increased p-ERK/ERK ratio (p < 0.001) and NF-ƙB level (p < 0.05) in sensitized rats compared to C group. The administration of C-kit+, but not C-Kit−, decreased p-ERK/ERK ratio and NF-ƙB level than those of S group (p < 0.05).
Conclusions

The study showed that C-Kit+ cells engrafted into pulmonary tissue reduced NF-ƙB protein level and diminished p-ERK/ERK ratio, leading to suppression of inflammatory response in asthmatic lungs.
Climatic Risk Zoning for Potential Occurrence of Cacao Moniliasis Disease in Northeastern Brazil Under The Influence of ENSO Phases
Authors: Galvão Ícaro Monteiro , Pereira Gislaine Silva , Sentelhas Paulo 
Published: June 2021

Abstract
Air temperature and relative humidity are the main drivers of many fungal diseases, such as moniliasis (Moniliophthora roreri), which affects cocoa production worldwide. This disease occurs in some Latin American countries; however, it has not yet occurred in Brazil. Moniliasis could cause serious damage to the Brazilian cocoa production if present in the country. Therefore, to know the risks of moniliasis to cocoa production in the largest Brazilian producing region, in the state of Bahia, this study investigated the climatic favorability for the occurrence of this disease in this state, by defining and mapping the climatic risks and by assessing the influence of El Niño Southern Oscillation (ENSO) phases on it. Daily air temperature and relative humidity data from 28 weather stations of the national weather network in the state of Bahia, between 1988 and 2018, were employed to determine the risk index for cocoa moniliasis occurrence (RICM), based on the number of days favorable to the disease, which was categorized in five levels of favorability, ranging from “unfavorable” to “very favorable”. Seasonal and annual RICM maps were generated by a multiple linear regression procedure, considering raster layers of latitude, longitude, and altitude. The maps showed a high spatial and temporal RICM variability in the state of Bahia, with the highest risk for moniliasis occurrence in the eastern part of the state, where most producing areas are located. The ENSO phase showed to influence cocoa moniliasis occurrence, with the years with a transition between El Niño and Neutral phases being the most critical for this disease in majority of assessed locations. These results show that cocoa producers in the state of Bahia, Brazil, should be concerned with moniliasis occurrence as a potential disease for their crops, mainly in the traditional producing regions and when ENOS is in a transition from El Niño to Neutral.