bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Sphere of Influence: Table Tennis Diplomacy and the National Committee on U.S.-China Relations
Authors: Crean Jeffrey 
Published: June 2021

Abstract
Prominent China studies academics who, with the assistance of members of the business and religious communities, founded the National Committee on United States-China Relations (ncuscr) in 1966 did not build it to last. Its leaders foresaw the organization’s work as “catalytic” and envisioned that it would be “going out of business as soon as possible.” By March 1971, with a new era of U.S. relations with China on the horizon, its leaders saw little reason to continue operations, and seriously contemplated closing up shop. Yet that April, the government of the People’s Republic of China hosted the U.S. Table Tennis team, and pledged to have its team make a reciprocal visit to the United States the following year, which the ncuscr funded and organized. This visit’s controversies mirrored the previous ideological divides the group had weathered. Conservative anti-Communist protesters and pro-Taiwan activists disrupted the earliest public events, but antiwar demonstrators, who appeared at later exhibition matches to protest President Richard M. Nixon’s bombing of Haiphong in North Vietnam, soon superseded them. Despite these pitfalls, the visit proved to be a great success for the nsuscr, which received a new lease on life and gained a renewed sense of purpose.
Coupled Air Quality and Boundary-Layer Meteorology in Western U.S. Basins during Winter: Design and Rationale for a Comprehensive Study
Authors: Hallar A. Gannet , Brown Steven S. , Crosman Erik , Barsanti Kelley C. , Cappa Christopher D. , Faloona Ian , Fast Jerome , Holmes Heather A. , Horel John , Lin John , Middlebrook Ann , Mitchell Logan , Murphy Jennifer , Womack Caroline C. , Aneja Viney , Baasandorj Munkhbayar , Bahreini Roya , Banta Robert , Bray Casey , Brewer Alan , Caulton Dana , de Gouw Joost , De Wekker Stephan F.J. , Farmer Delphine K. , Gaston Cassandra J. , Hoch Sebastian , Hopkins Francesca , Karle Nakul N. , Kelly James T. , Kelly Kerry , Lareau Neil , Lu Keding , Mauldin Roy L. , Mallia Derek V. , Martin Randal , Mendoza Daniel L. , Oldroyd Holly J. , Pichugina Yelena , Pratt Kerri A. , Saide Pablo E. , Silva Philip J. , Simpson William , Stephens Britton B. , Stutz Jochen , Sullivan Amy 
Published: June 2021

AbstractWintertime episodes of high aerosol concentrations occur frequently in urban and agricultural basins and valleys worldwide. These episodes often arise following development of persistent cold-air pools (PCAPs) that limit mixing and modify chemistry. While field campaigns targeting either basin meteorology or wintertime pollution chemistry have been conducted, coupling between interconnected chemical and meteorological processes remains an insufficiently studied research area. Gaps in understanding the coupled chemical–meteorological interactions that drive high-pollution events make identification of the most effective air-basin specific emission control strategies challenging. To address this, a September 2019 workshop occurred with the goal of planning a future research campaign to investigate air quality in western U.S. basins. Approximately 120 people participated, representing 50 institutions and five countries. Workshop participants outlined the rationale and design for a comprehensive wintertime study that would couple atmospheric chemistry and boundary layer and complex-terrain meteorology within western U.S. basins. Participants concluded the study should focus on two regions with contrasting aerosol chemistry: three populated valleys within Utah (Salt Lake, Utah, and Cache Valleys) and the San Joaquin Valley in California. This paper describes the scientific rationale for a campaign that will acquire chemical and meteorological datasets using airborne platforms with extensive range, coupled to surface-based measurements focusing on sampling within the near-surface boundary layer, and transport and mixing processes within this layer, with high vertical resolution at a number of representative sites. No prior wintertime basin-focused campaign has provided the breadth of observations necessary to characterize the meteorological–chemical linkages outlined here, nor to validate complex processes within coupled atmosphere–chemistry models.
Tropical Cyclone Footprints in Long-Term Mean State and Multiscale Climate Variability in the Western North Pacific as Seen in the JRA-55 Reanalysis
Authors: Arakane Sho , Hsu Huang-Hsiung 
Published: June 2021

AbstractThe monsoon trough and subtropical high have long been acknowledged to exert a substantial modulating effect on the genesis and development of tropical cyclones (TCs) in the western North Pacific (WNP). However, the potential upscaling effect of TCs on large-scale circulation remains poorly understood. This study revealed the considerable contributions of TCs to the climate mean state and variability in the WNP between 1958 and 2019, characterized by a strengthened monsoon trough and weakened subtropical anticyclonic circulation in the lower troposphere, enhanced anticyclonic circulation in the upper troposphere, and warming throughout the troposphere. TCs constituted distinct footprints in the long-term mean states of the WNP summer monsoon, and their contributions increased intraseasonal and interannual variance by 50%–70%. The interdecadal variations and long-term trends in intraseasonal variance were mainly due to the year-to-year fluctuations in TC activity. The size of TC footprints was positively correlated with the magnitude of TC activity. Our findings suggest that the full understanding of climate variability and changes cannot be achieved simply on the basis of low-frequency, large-scale circulations. Rather, TCs must be regarded as a crucial component in the climate system, and their interactions with large-scale circulations require thorough exploration. The long-term dataset created in this study provides an opportunity to study the interaction between TCs and TC-free large-scale circulations to advance our understanding of climate variability in the WNP. Our findings also indicate that realistic climate projections must involve the accurate simulations of TCs.
Nelfinavir restricts A549 cell growth by inhibiting STAT3 signaling
Authors: He Fangli , Wang Gang , Xu ZhengQing , Huang Zhihui 
Published: June 2021

Objective To investigate the anticancer effect of nelfinavir (NFV) on human A549 cells. Methods The inhibitory effects of NFV on the proliferation of human A549 cells were assessed using a MTT assay. Apoptotic cells were observed by fluorescence microscopy following Hoechst 33342 staining. Apoptosis of A549 cells was assessed using Annexin-V/propidium iodide staining and flow cytometry. Expression levels of signal transducer and activator of transcription 3 (STAT3) and p-STAT3 were measured by western blotting. STAT3 RNA silencing was used to investigate the pro-apoptotic mechanism of NFV in A549 cells. Results NFV dose-dependently suppressed proliferation of human A549 cells and induced significant apoptosis. Western blotting showed that the antitumor function of NFV might be mediated by STAT3 inhibition. A549 cell apoptosis in response to 20 µM NFV was significantly increased following STAT3 silencing. NFV significantly impeded the expression of the anti-apoptotic proteins Bcl-xL and Bcl-2, by increased the expression of the pro-apoptotic protein Cle-PARP. Conclusions Our findings highlight STAT3 as a promising therapeutic target. NFV is a novel anti-cancer drug for the treatment of non-small-cell lung cancer.
Prevalence and clinical characteristics of septicemia in children with Mycoplasma pneumoniae pneumonia
Authors: Liu Li , Maharjan Shobha , Sun Jia-Liang , Li Yan-Chun , Cheng Huan-Ji 
Published: June 2021

Background Mycoplasma pneumoniae (MP) pneumonia in children can be challenging to treat, and the impact of MP blood infection is unclear. The present study aims to determine the prevalence and clinical characteristics of MP septicemia among pediatric patients. Methods Children hospitalized at our center for MP pneumonia between October 2017 and June 2018 were included. Healthy controls visiting our outpatient clinic for regular physical examinations were also enrolled. MP was detected by real-time polymerase chain reaction (qPCR) analysis of plasma and peripheral blood mononuclear cell (PBMC) samples. Results Sixty-one children with MP pneumonia and 30 healthy children were included. Among children with MP infection, 31 (50.8%) were positive for MP by qPCR (19 in plasma samples, 8 in PBMC samples, and 4 in both). All healthy controls were negative for MP by qPCR. Conclusions The prevalence of MP septicemia in children with MP pneumonia is moderate. However, detection of MP in blood samples may have limited clinical value for guiding treatment.
Perceived Discrimination, Retention, and Diabetes Risk Among American Indians and Alaska Natives in a Diabetes Lifestyle Intervention
Authors: Gonzales Kelly L. , Jiang Luohua , Garcia-Alexander Ginny , Jacob Michelle M. , Chang Jenny , Williams David R. , Bullock Ann , Manson Spero M. 
Published: June 2021

Objectives: To examine the association of perceived discrimination with participant retention and diabetes risk among American Indians and Alaska Natives. Methods: Data were drawn from the Special Diabetes Program for Indians–Diabetes Prevention Demonstration Project ( N = 2553). Results: Perceived discrimination was significantly and negatively associated with short-term and long-term retention and diabetes risk without adjusting. After controlling for socioeconomic characteristics and clinical outcomes, perceived discrimination was not associated with retention but was significantly associated with less improvement in body mass index (BMI) and high-density lipoprotein (HDL) cholesterol. Every unit increase in the perceived discrimination score was associated with 0.14 kg/m2 less BMI reduction (95% CI: [0.02, 0.26], p = 0.0183) and 1.06 mg/dl lower HDL at baseline (95% CI: [0.36, 1.76], p = 0.0028). Discussion: Among racialized groups, improving retention and health in lifestyle interventions may require investigating perceived discrimination and the broader context of structural racism and colonialism.
Older and Wiser? Age Moderates the Association Between Discrimination and Depressive Symptoms in American Indians and Alaska Natives
Authors: Danyluck Chad , Blair Irene V. , Manson Spero M. , Laudenslager Mark L. , Daugherty Stacie L. , Jiang Luohua , Brondolo Elizabeth 
Published: June 2021

Objectives: To examine age differences in the association between discrimination and depressive symptoms among urban American Indians and Alaska Natives (AI/AN). Methods: A sample of 303 urban AI/AN (18–78 years old) reported on lifetime and past-week experiences of racial discrimination and depressive symptoms. Depressive symptoms were regressed on racial discrimination, age, and their interaction, adjusting for demographic factors and other life stressors. Results: Lifetime and past-week discrimination were significantly associated with depressive symptoms, and these associations were stronger among younger than older adult AI/AN. Discussion: The results are consistent with prior reports in other populations, but this is the first such study to focus on AI/AN, and it highlights the importance of considering life course perspectives. Conclusions are limited by the cross-sectional nature of the data. Longitudinal and qualitative work is needed to understand why discrimination may have a stronger effect on mental health for younger than older AI/AN.
Video-assisted cardiopulmonary resuscitation: Does the camera perspective matter? A randomized, controlled simulation trial
Authors: Wetsch Wolfgang A. , Ecker Hannes M. , Scheu Alexander , Roth Rebecca , Böttiger Bernd W. , Plata Christopher 
Published: June 2021

Background Dispatcher assistance can help to save lives during layperson cardiopulmonary resuscitation during cardiac arrest. The aim of this study was to investigate the influence of different camera positions on the evaluation of cardiopulmonary resuscitation performance during video-assisted cardiopulmonary resuscitation. Methods For this randomized, controlled simulation trial, seven video sequences of cardiopulmonary resuscitation performance were recorded from three different camera positions: side, foot and head position. Video sequences showed either correct cardiopulmonary resuscitation performance or one of the six typical errors: low and high compression rate, superficial and increased compression depth, wrong hand position or incomplete release. Video sequences with different cardiopulmonary resuscitation performances and camera positions were randomly combined such that each evaluator was presented seven individual combinations of cardiopulmonary resuscitation and camera position and evaluated each cardiopulmonary resuscitation performance once. A total of 46 paramedics and 47 emergency physicians evaluated seven video sequences of cardiopulmonary resuscitation performance from different camera positions. The primary hypothesis was that there are differences in accuracy of correct assessment/error recognition depending on camera perspective. Generalized linear multi-level analyses assuming a binomial distribution and a logit link were employed to account for the dependency between each evaluator's seven ratings. Results Of 651 video sequences, cardiopulmonary resuscitation performance was evaluable in 96.8% and correctly evaluated in 74.5% over all camera positions. Cardiopulmonary resuscitation performance was classified correctly from a side perspective in 81.3%, from a foot perspective in 68.8% and from a head perspective in 73.6%, revealing a significant difference in error recognition depending on the camera perspective ( p = .01). Correct cardiopulmonary resuscitation was mistakenly evaluated to be false in 46.2% over all perspectives. Conclusions Participants were able to recognize significantly more mistakes when the camera was located on the opposite side of the cardiopulmonary resuscitation provider. Foot position should be avoided in order to enable the dispatcher the best possible view to evaluating cardiopulmonary resuscitation quality.
Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function
Authors: Demetriou Eleni A , Pepper Karen L , Park Shin Ho , Pellicano Liz , Song Yun Ju C , Naismith Sharon L , Hickie Ian B , Thomas Emma E , Guastella Adam J 
Published: June 2021

Sex differences in autism may in part be understood by an atypical sex profile of executive function and non-executive function. In this study, we compared females and males with autism against non-autistic individuals on neuropsychological and self-report measures to examine whether any sex differences in executive function and non-executive function might be unique to autism. Our study showed a significant overall female advantage for measures of psychomotor speed, cognitive flexibility, verbal learning and memory and semantic fluency. There was no significant interaction effect between diagnosis and sex. No sex differences were observed on the self-report measure of executive function. Our results suggest that while females show different cognitive performance to males, these sex differences were not specific to the autistic cohort. Lay abstract Research comparing females and males with a diagnosis of autism suggests that there are sex differences in some characteristics such as behaviour regulation. One area not studied in detail is whether females and males with autism perform differently in tests of cognitive ability. The results of previous research are quite mixed. One explanation may be that some research comparing females and males with autism did not include a neurotypical control group for comparison. As a result, it is not clear whether the sex differences in cognitive ability observed in people with autism are similar to differences between neurotypical males and females. To better understand whether there are unique differences between males and females with autism, it is important to also compare them with neurotypical males and females. In our research, we included a neurotypical group and compared males and females with and without a diagnosis of autism. We found that the sex differences in autism are similar to what we observe in males and females without autism. Our study showed that compared with males, females (with and without autism) do better in assessments of processing speed, cognitive flexibility, verbal learning and memory and semantic fluency. Our results suggest that although females show different cognitive performance to males, these sex differences were not specific to the group with a diagnosis of autism.
Nonlinear Relationship Between Age and Likelihood of Undergoing Prostate-Specific Antigen Testing, and the Predictive Factors of Testing at Different Ages
Authors: He Hairong , Liu Tianjie , Zhao Fanfan , Feng Xiaojie , Lyu Jun , Gao Ye 
Published: June 2021

Objective: To investigate the nonlinear relationship between age and the likelihood of undergoing prostate-specific antigen (PSA) testing, and the difference of factors influencing the test likelihood among subjects aged 40–54, 55–69, and ≥70 years. Methods: Data were extracted from the 2018 Behavioral Risk Factor Surveillance System, with the primary outcome defined as receipt of a PSA test within the previous 12 months. Restricted cubic splines were used to assess the relationship between age and the likelihood of undergoing PSA testing. Backward conditional logistic regression analyses were used to identify the predictors of undergoing PSA testing among subjects aged 40–54, 55–69, and ≥70 years. Results: Finally, 92,177 people were identified. The likelihood of PSA testing increased up to around 71 years old and then decreased rapidly for higher ages, showing a clear nonlinear inverted U-shaped relationship with age ( p < .001). Insurance status, shared decision-making, whether a recommendation for PSA testing had been accepted, income level, smoking status, and age were the common predictors of testing in the three age groups. However, the predictors differed somewhat among the three groups: being overweight or obese was only positively associated with increased testing among people aged 40–54 and ≥70 years, being retired only greatly impacted the test likelihood among those aged 40–54 years, and the general health status, marital status, and race affected people aged ≥55 years. Conclusion: The factors influencing PSA screening differ with age, which should be fully considered when screening different target age groups.
Screening of Work-Related Musculoskeletal Upper Limb Disorders Using the SALTSA Protocol: A Work-Site Study in Belgium
Authors: Van Dyck Lieve , Baecke Monique , Grosjean Marie , Isaie Habyalimana , Gregoire Yannick , Barbieux Christine , Tock Ryan , Verbrugghe Mathieu 
Published: June 2021

Background: Long-term absenteeism continues to rise in Belgium and musculoskeletal disorders (MSDs) have been considered a primary cause. However, there is still uncertainty about the prevalence of MSDs, and about the contribution of work-related factors in the etiology of MSDs. SALTSA, which was developed in 2001, is a European diagnostic criterion document that aims to standardize the reporting of work-related upper limb MSDs (ULMSDs). The purpose of this work-site study was to implement SALTSA in daily occupational health practice and to determine the prevalence of ULMSDs in a Belgian company. Methods: During health examinations, occupational health nurses and an occupational health physician screened employees in a company with ergonomically high-risk activities for the occurrence of ULMSDs using the SALTSA protocol. In order to explore associations between ULMSDs and lifestyle and work-related factors, bivariate and logistic regression analyses were performed. Findings: Three hundred and eight (94.0%, 308/328) employees were screened resulting in an ULMSD prevalence of 20.5% (95% CI = [16.0–25.3]). Rotator cuff syndrome was the most common condition. Prevalence varied significantly between men (9.6%, 95% CI = [5.6–14.9]) and women (35.0%, 95% CI = [26.9–43.9]). Being female ( p < .001) and working in the cabling assembly unit ( p = .002) were found to be significant predictors of ULMSDs. Conclusion/Application to Practice: By using the SALTSA protocol in occupational health practices, ULMSDs can be screened unequivocally, enabling comparisons between different occupational sectors and countries. Occupational health nurses can play an important role in detecting and screening MSDs among workers.
Biomechanical Effects of Combined Anterior Cruciate Ligament Reconstruction and Anterolateral Ligament Reconstruction: A Systematic Review and Meta-analysis
Authors: Kelly Shayne R. , Cutter Brendan M. , Huish Eric G. 
Published: June 2021

Background: Combined anterior cruciate ligament (ACL) reconstruction (ACLR) and anterolateral ligament reconstruction (ALLR) are performed with the intention to restore native knee kinematics after ACL tears. There continue to be varying results as to the difference in kinematics between combined and isolated procedures, including anterior tibial translation (ATT) and internal tibial rotation (IR). Purpose: To perform a systematic review and meta-analysis to evaluate the kinematic changes of a combined ACLR/ALLR versus isolated ACLR and to assess the effects of different fixation techniques. Study Design: Systematic review. Methods: We conducted a systematic review and meta-analysis of 15 human cadaveric biomechanical studies evaluating combined ACLR/ALLR versus isolated ACLR and their effects on ATT and IR in 149 specimens. The primary outcomes were ATT and IR. Secondary outcomes included graft type and size as well as fixation methods such as type, angle, tension, and position of fixation. Meta-regression was used to examine the effect of various cofactors on the resulting measures. Results: Compared with isolated ACLR, combined ACLR/ALLR decreased ATT and IR by 0.01 mm (95% CI, –0.059 to 0.079 mm; P = .777) and 1.64° (95% CI, 1.30°-1.98°; P < .001), respectively. Regarding ACLR/ALLR, increasing the knee flexion angle and applied IR force led to a significant reduction in IR ( P < .001 and P = .044, respectively). There was also a significant reduction in IR in combined procedures with semitendinosus ALL graft, higher flexion fixation angles, and tension but no change in IR with differing femoral fixation points ( P < .001, P < .001, and P = .268, respectively). Multivariate meta-regression showed that the use of tibial-sided suture anchor fixation significantly reduced IR ( P < .001). Conclusion: These results suggest that a combined ACLR/ALLR procedure significantly decreases IR compared with isolated ACLR, especially at higher knee flexion angles. Semitendinosus ALL graft, fixation at higher knee flexion, increased tensioning, and tibial-sided interference screw fixation in ALLR may help to further reduce IR.