bluuebunny/crossref_metadata_2025_split huggingface dataset:
TaintBench: Automatic real-world malware benchmarking of Android taint analyses
Authors: Luo Linghui , Pauck Felix , Piskachev Goran , Benz Manuel , Pashchenko Ivan , Mory Martin , Bodden Eric , Hermann Ben , Massacci Fabio 
Published: October 2021

AbstractDue to the lack of established real-world benchmark suites for static taint analyses of Android applications, evaluations of these analyses are often restricted and hard to compare. Even in evaluations that do use real-world apps, details about the ground truth in those apps are rarely documented, which makes it difficult to compare and reproduce the results. To push Android taint analysis research forward, this paper thus recommends criteria for constructing real-world benchmark suites for this specific domain, and presents TaintBench, the first real-world malware benchmark suite with documented taint flows. TaintBench benchmark apps include taint flows with complex structures, and addresses static challenges that are commonly agreed on by the community. Together with the TaintBench suite, we introduce the TaintBench framework, whose goal is to simplify real-world benchmarking of Android taint analyses. First, a usability test shows that the framework improves experts’ performance and perceived usability when documenting and inspecting taint flows. Second, experiments using TaintBench reveal new insights for the taint analysis tools Amandroid and FlowDroid: (i) They are less effective on real-world malware apps than on synthetic benchmark apps. (ii) Predefined lists of sources and sinks heavily impact the tools’ accuracy. (iii) Surprisingly, up-to-date versions of both tools are less accurate than their predecessors.
Evaluating the influence of environmental variables on fish assemblages along Tropical Andes: considerations from ecology to conservation
Authors: Miranda Rafael , Rios-Touma Blanca , Falconí-López Ana , Pino-del-Carpio Andrea , Gaspar Sergio , Ortega Hernán , Peláez-Rodríguez Marlon , Araujo-Flores Julio Manuel , Tobes Ibon 
Published: October 2021

AbstractThe lack of knowledge about freshwater biodiversity in remote areas like montane Andean rivers is noticeable and hinder the development of efficient conservation plans for aquatic ecosystems. Habitat requirements of tropical Andean fishes have been poorly analysed, despite the relevance of these ecological features on the fish conservation strategies. The present study aimed to examine fish assemblages along the altitudinal gradient in tropical Andean rivers and their relationship to habitat features to detect the most relevant abiotic factors and their implication on conservation. This study was conducted on a regional scale, along six basins located in tropical Andes (500 to 2,692 m a.s.l.). We studied fish diversity and distribution and their habitats along these elevation gradients. We found 6,320 specimens from 53 genera. Our analysis for the six most common and widely distributed genera (Astroblepus,Brycon,Bryconamericus,Chaetostoma,PimelodellaandTrichomycterus) underlines the relevance of hydromorphological variables on fish community structure in the Andean montane rivers, whereas human alterations seem to be less significant. These findings could be useful for current management and conservation strategies considering present threats over tropical montane rivers.
Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling
Authors: Chen Yirong , Que Renye , Zhang Na , Lin Liubing , Zhou Mengen , Li Yong 
Published: October 2021

Abstract
Background
Hepatic fibrosis is the final pathway of chronic liver disease characterized by excessive accumulation of extracellular matrix (ECM), which eventually develop into cirrhosis and liver cancer. Emerging studies demonstrated that Saikosaponin-d (SSd) exhibits a protective role in liver fibrosis. However, the mechanism underlying anti-liver fibrosis of SSd in vivo and in vitro remains unclear.

Methods and results
Transforming growth factor (TGF)-β and carbon tetrachloride (CCl4) were used for creating liver fibrosis model in vitro and in vivo, respectively. The role of SSd in regulating liver fibrosis was assessed through Sirius red and Masson staining, and IHC assay. We found that SSd attenuated remarkably CCl4-induced liver fibrosis as evidenced by decreased collagen level, and decreased expression of fibrotic markers Col 1 and α-SMA. Meanwhile, SSd repressed autophagy activation as suggested by decreased BECN1 expression and increased p62 expression. Compared with HSCs from CCl4-treated group, the primary HSCs from SSd-treated mice exhibited a marked inactivation of autophagy. Mechanistically, SSd treatment enhanced the expression of GPER1 in primary HSCs and in TGF-β-treated LX-2 cells. GPER1 agonist G1 repressed autophagy activation, whereas GPER1 antagonist G15 activated autophagy and G15 also damaged the function of SSd on suppressing autophagy, leading to subsequent increased levels of fibrotic marker level in LX-2 cells.

Conclusions
Our findings highlight that SSd alleviates hepatic fibrosis by regulating GPER1/autophagy pathway.
How human capital, universities of excellence, third party funding, mobility and gender explain productivity in German political science
Authors: Habicht Isabel M. , Lutter Mark , Schröder Martin 
Published: October 2021

AbstractUsing a unique panel dataset of virtually all German academic political scientists, we show that researchers become much more productive due to the accumulation of human capital and third party funding. We also show however, that while universities of excellence have more productive researchers, individuals who go there do not become more productive. Finally, we show how women publish only 9 percent less than men with the same level of prior publication experience, but are about 26 percent less productive over their entire career, as early productivity leads to later productivity, so that women increasingly fall behind. These results cannot be explained through the influence of childbearing. Rather, they support the ‘theory of limited differences’, which argues that small differences in early productivity accumulate to large differences over entire careers, as early success encourages later success. Apart from generally showing why political scientists publish more or less, we specifically identify accumulative advantage as the principal reason why women increasingly fall behind men over the course of their careers.
Characterization of Flow Induced Anisotropy in Sheet Metal at Large Strain
Authors: Gutknecht F. , Traphöner H. , Clausmeyer T. , Tekkaya A. E. 
Published: October 2021

Abstract
Background
Many metals exhibit a stress overshoot, the so-called cross-hardening when subjected to a specific strain-path change. Existing tests for sheet metals are limited to an equivalent prestrain of 0.2 and show varying levels of cross-hardening for identical grades.

Objective
The aim is to determine cross-hardening at large strains, relevant for forming processes. Mild steel grades (DC04, DC06, DX56) and high strength steel grades (BS600, DP600, ZE800) are investigated to quantify the level of cross-hardening between different grades and reveal which grades exhibit cross-hardening at all.

Method
A novel test setup for large prestrain using hydraulic bulge test and torsion of curved sheets is developed to achieve an orthogonal strain-path change, i.e. the strain rate tensors for two subsequent loadings are orthogonal. The influence of strain rate differences between the tests and clamping of curved sheets on the determined cross-hardening are evaluated. The results are compared to experiments in literature.

Results
Cross-hardening for sheet metal at prestrains up to 0.6 true plastic strain are obtained for the first time. For DX56 grade the maximum cross-hardening for all prestrains have a constant level of approximately 6%, while the maximum cross-hardening for DC04 and DC06 grades increases, with levels between 7 and 11%. The high strength grades BS600 and ZE800 do not show cross-hardening behavior, while, differencing from previous publications, cross-hardening is observed for dual phase steel DP600.

Conclusion
Depending on the microstructure of the steel grade the cross-hardening increases with large prestrain or remains constant.
Mechanistic study of nanoparticles-assisted xanthan gum polymer flooding for enhanced oil recovery: a comparative study
Authors: Gbadamosi Afeez , Yusuff Adeyinka , Agi Augustine , Muruga Prem , Junin Radzuan , Jeffrey Oseh 
Published: October 2021

AbstractRecently, nanoparticle additives have been used to improve stability and hence efficiency of chemicals during enhanced oil recovery. Herein, a comparative analysis of the application of nanoparticle-stabilized xanthan gum for oil recovery applications was investigated. The nanoparticles used as additives are silicon oxide (SiO2), metallic aluminium oxide (Al2O3), and titanium oxide (TiO2). Rheological measurements were carried out to examine the shear viscosity of the polymeric nanofluids under a range of salinity typical of reservoir conditions. Interfacial tension (IFT) experiment was conducted using Kruss tensiometer. Oil displacement studies were carried out to examine the incremental recovery factor of the polymeric nanofluids. The polymeric nanofluids exhibited better rheological behaviour compared to bare xanthan gum (XG) polymer. At 0.5 wt.% nanoparticle concentration, 0.5 wt.% polymer concentration, shearing rate of 10 s−1, and 3 wt.% NaCl concentration, rheology result shows that the shear viscosity of SiO2-XG, Al2O3-XG, and TiO2-XG is 423 mPa.s, 299 mPa.s, and 293 mPa.s, respectively. Moreover, the polymeric nanofluids lowered the IFT of the oil/brine interface due to adsorption at the nanoparticles at the interface. Finally, oil displacement result confirms that the incremental oil recovery after water flooding by Al2O3-XG, TiO2-XG, and SiO2-XG is 28.4%, 27.6%, and 25.2%, respectively.
Neurological Presentations in Patients with COVID-19 in Cytokine Storm
Authors: Tutal Gursoy Gorkem , Yuksel Hatice , Mulkem Simsek Inci , Oral Saniye , Erdogan Kucukdagli Fadime , Karaman Ayberk , Akinci Esragul , Bastug Aliye , Guner Hatice Rahmet , Bektas Hesna 
Published: October 2021

Abstract:Background:Coronavirus disease 2019 (COVID-19) infection causes a wide variety of neurological disorders by affecting both central and peripheral nervous systems. The cytokine storm (CS) has been blamed for the development of severe neurological disorders in COVID-19. However, the relationship between COVID-19 CS and neurological manifestations has not been adequately studied. Thus, we aimed to investigate the neurological presentations in patients with COVID-19 CS.Methods:The study population consisted of hospitalized moderate-to-severe COVID-19 patients. It was divided into two groups CS (36 patients, 29.3%) and non-CS (87 patients, 70.7%) based on significant clinical symptoms, elevated inflammatory marker levels, radiological findings, and interleukin-6 levels (IL-6).Results:The three most common neurological symptoms in the CS group were altered level of consciousness, headache, and unsteadiness. Altered level of consciousness was higher in the CS group (69.4%) than the non-CS group (25.3%) (p:0.001). The frequency of headache was comparable in both groups (p:0.186). The number of patients requiring intensive care unit and intubation was higher in the CS group (p:0.005 and p:0.001). The mortality rate in the CS group (38.9%) was higher than the non-CS group (8.0%) (p:0.001). IL-6, CRP, ferritin, neutrophil-lymphocyte ratio, procalcitonin, and D-dimer levels were higher in the CS group (for all p:0.001) while lymphocyte count was lower (p:0.003).Conclusion:The most common neurological presentation in patients with CS was altered level of consciousness. The presence of CS was an independent risk factor for high mortality.
The Risk of Obsolescence: Reframing the Contemporary Use of Force Model to Achieve a More Holistic Application of the UN Charter Jus Ad Bellum Construct
Authors: COX BRIAN L. 
Published: October 2021

AbstractThis article challenges the effectiveness of the prevailing interpretation of the contemporary use of force model that is centred on a decidedly narrow selection of relevant provisions of the Charter of the United Nations (UN Charter). In the now seventy-five years of the UN Charter era, predominant modes of armed conflict have evolved so as to be largely unrecognizable when compared to the model of war that was contemplated when negotiating and ratifying the Charter. Nonetheless, modes of engaging with an actual or contemplated use of force remain rooted in a model developed more than seven decades ago. This article suggests that a new frame of analysis is needed. The “Reframer” approach and “Purposes and Principles” model developed herein remain just as firmly grounded in the UN Charter as the prevailing interpretation. However, this novel approach and model incorporate a degree of nuance and adaptiveness that is not feasible when applying the prevailing interpretation of the contemporary use of force model.
Preparedness for Mass Casualty Incidents: The Effectiveness of Current Training Model
Authors: Biswas Seema , Bahouth Hany , Solomonov Evgeny , Waksman Igor , Halberthal Michael , Bala Miklosh 
Published: October 2021

AbstractThe importance of MCI organization and training was highlighted by the events of September 11, 2001. Training focuses on the management of physical injuries caused by a single traumatic event over a well-defined, relatively short timeframe. MCI management is integrated into surgical and trauma training, with disaster management training involving the emergency services, law enforcement, and state infrastructure agencies. The COVID-19 pandemic revealed gaps in the preparedness of nation states and global partners in disaster management. The questions that arose include ‘has training really prepared us for an actual emergency,’ ‘what changes need to be made to training to make it more effective,’ and ‘who else should training be extended to?’ This article focuses on the importance of involving multiple sectors in mass casualty training and asks whether greater involvement of non-medical agencies and the public, in operational drills might improve preparedness for global events such as the COVID-19 pandemic.
COPYING ONE OF A PAIR OF STRUCTURES
Authors: ALVIR RACHAEL , BURCHFIELD HANNAH , KNIGHT JULIA F. 
Published: October 2021

AbstractWe ask when, for a pair of structures
$\mathcal {A}_1,\mathcal {A}_2$
, there is a uniform effective procedure that, given copies of the two structures, unlabeled, always produces a copy of
$\mathcal {A}_1$
. We give some conditions guaranteeing that there is such a procedure. The conditions might suggest that for the pair of orderings
$\mathcal {A}_1$
of type
$\omega _1^{CK}$
and
$\mathcal {A}_2$
of Harrison type, there should not be any such procedure, but, in fact, there is one. We construct an example for which there is no such procedure. The construction involves forcing. On the way to constructing our example, we prove a general result on modifying Cohen generics.
Rapid Assembly and Eruption of a Shallow Silicic Magma Reservoir, Reyðarártindur Pluton, Southeast Iceland
Authors: Rhodes E. L. , Barker A. K. , Burchardt S. , Hieronymus C. F. , Rousku S. N. , McGarvie D. W. , Mattsson T. , Schmiedel T. , Ronchin E. , Witcher T. 
Published: October 2021

AbstractAlthough it is widely accepted that shallow silicic magma reservoirs exist, and can feed eruptions, their dynamics and longevity are a topic of debate. Here, we use field mapping, geochemistry, 3D pluton reconstruction and a thermal model to investigate the assembly and eruptive history of the shallow Reyðarártindur Pluton, southeast Iceland. Primarily, the exposed pluton is constructed of a single rock unit, the Main Granite (69.9–77.7 wt.% SiO2). Two further units are locally exposed as enclaves at the base of the exposure, the Granite Enclaves (67.4–70.2 wt.% SiO2), and the Quartz Monzonite Enclaves (61.8–67.3 wt.% SiO2). Geochemically, the units are related and were likely derived from the same source reservoir. In 3D, the pluton has a shape characterized by flat roof segments that are vertically offset and a volume of >2.5 km3. The pluton roof is intruded by dikes from the pluton, and in two locations displays depressions associated with large dikes. Within these particular dikes the rock is partially to wholly tuffisitic, and rock compositions range from quartz monzonite to granite. We interpret these zones as eruption‐feeding conduits from the pluton. A lack of cooling contacts throughout the pluton indicates rapid magma emplacement and a thermal model calculates the top 75 m would have rheologically locked up within 1,000 years. Hence, we argue that the Reyðarártindur Pluton was an ephemeral part of the wider plumbing system that feeds a volcano, and that timeframes from emplacement to eruption were rapid.
From Seismic Quiescence to Surged Activity After Decades of Wastewater Disposal: A Case Study in Central‐West Alberta, Canada
Authors: Yu Hongyu , Kao Honn , Visser Ryan , Wang Bei 
Published: October 2021

AbstractInjection‐induced earthquakes associated with wastewater disposal (WD) in the Western Canadian Sedimentary Basin are much fewer than those linked to hydraulic fracturing. Recently, 43 WD‐related earthquakes (M1.3–3.9) occurred in a historically seismically quiet area where long‐term injections became intensive since 2018, foreshadowing a critical stress state accumulated from long‐term injections. Our improved earthquake locations show that the injection well targeting the deeper middle‐upper Devonian aquifer system causes more vigorous seismicity with a wide range of stress drop values (0.8–230 MPa) compared to other shallower wells. Three physical mechanisms may collectively lead to the observed seismic pattern: (a) the underlying Devonian reef system makes it easier for injected fluids to migrate horizontally, (b) fluids can be channeled into the widespread critical faults and migrate vertically to cause earthquakes along it, and (c) aseismic slip probably triggered within the Duvernay formation by fluid migrating can further facilitate seismicity at shallower depths.
Long‐Distance/Time Surf‐Zone Tracer Evolution Affected by Inner‐Shelf Tracer Retention and Recirculation
Authors: Grimes D. J. , Feddersen F. , Giddings S. N. 
Published: October 2021

AbstractThe evolution of a surf‐zone released tracer ( Liter over 4 hr) was observed for h. Surf‐zone tracer was transported alongshore (y) with relatively steady mean speed vSZ ≈ 0.18 m s−1, consistent with obliquely incident wave forcing. Maximum in situ surf‐zone tracer concentration decayed exponentially with 1.6 km alongshore e‐folding length scale, that is, 2.5 hr advective time scale. Surf‐zone tracer time‐series evolved downstream of the release from a top‐hat structure for y ≤ 1 km to increasingly skewed farther downstream. Within km of the northward propagating tracer front, inner‐shelf tracer was confined to onshore of (surf‐zone width LSZ ≈ 100 m) and was alongshore patchy. A coupled surf‐zone/inner‐shelf tracer advection‐diffusion‐exchange box model reproduces the observed surf‐zone downstream max concentration decay and temporal skewness, with surf‐zone flushing time h. A weaker inner‐shelf unidirectional‐exchange rate kIS ≈ kSZ/2 indicates reduced horizontal mixing outside the surf‐zone. Surf‐zone temporal skewness is linked to inner‐shelf tracer storage, differential surf‐zone/inner‐shelf advection, and recirculation, that is, non‐asymptotic shear dispersion. On the inner‐shelf (), tracer vertical structure differed in the morning versus afternoon suggesting internal tide and solar forced thermal modulation. Model parameters representing surf‐zone processes are well constrained by existing observations and scales. However, the many overlapping inner‐shelf processes make a single process based generalization of inner‐shelf cross‐shore exchange rate (i.e., kIS) and alongshore transport difficult.
Characterizing the Effect of Capillary Heterogeneity on Multiphase Flow Pulsation in an Intermediate‐Scale Beadpack Experiment Using Time Series Clustering and Frequency Analysis
Authors: Ni Hailun , Meckel T. A. 
Published: October 2021

AbstractAn intermediate‐scale beadpack drainage experiment was conducted to investigate how simple layered lamination heterogeneity affects CO2 flow. Two simple layers of capillary barriers are manually packed in the tank and slow drainage was carried out using analog fluids to mimic the capillary‐ and gravity‐dominated CO2 upward migration process in deep saline aquifers. Nonwetting phase saturation time series clustering analysis and frequency analysis have been conducted on the experimental data. Additionally, modified invasion percolation numerical simulations were done on a digital model of the beadpack to compare to experimental results. Results show that capillary barriers can lead to strong pulsation behavior, which in turn can cause unexpected early breaching through other barriers. The inlet pressure is found to be able to respond to saturation changes in far regions of the domain, indicating that the wetting phase can transmit pressure changes from the other phase. Although static simulations were not able to capture all the dynamic behavior observed in the experiment, Monte Carlo composite simulation results combining many different realizations can better illustrate how the nonwetting phase will behave in the heterogeneous domain. Our results suggest the need for CO2 storage site selection with preference given to aquifers with more capillary barriers with finer grain sizes to avoid flow pulsation and to retard plume upward migration.
Effects of placebo administration on immune mechanisms and relationships with central endogenous opioid neurotransmission
Authors: Prossin Alan , Koch Alisa , Campbell Phillip , Laumet Geoffroy , Stohler Christian S. , Dantzer Robert , Zubieta Jon-Kar 
Published: October 2021

AbstractBehavioral conditioning and expectation can have profound impact on animal and human physiology. Placebo, administered under positive expectation in clinical trials, can have potent effects on disease pathology, obscuring active medications. Emerging evidence suggests placebo-responsive neurotransmitter systems (e.g., endogenous opioid) regulate immune function by manipulating inflammatory proteins including IL-18, a potent pro-inflammatory, nociceptive cytokine implicated in pathophysiology of various diseases. Validation that neuroimmune interactions involving brain μ-opioid receptor (MOR) activity and plasma IL-18 underlie placebo analgesic expectation could have widespread clinical applications. Unfortunately, current lack of mechanistic clarity obfuscates clinical translation. To elucidate neuroimmune interactions underlying placebo analgesia, we exposed 37 healthy human volunteers to a standardized pain challenge on each of 2 days within a Positron Emission Tomography (PET) neuroimaging paradigm using the MOR selective radiotracer, 11C-Carfentanil (CFN). Each day volunteers received an intervention (placebo under analgesic expectation or no treatment), completed PET scanning, and rated their pain experience. MOR BPND parametric maps were generated from PET scans using standard methods. Results showed placebo reduced plasma IL-18 during pain (W74 = −3.7, p < 0.001), the extent correlating with reduction in pain scores. Placebo reduction in IL-18 covaried with placebo-induced endogenous opioid release in the left nucleus accumbens (T148 = 3.33; puncorr < 0.001) and left amygdala (T148 = 3.30; puncorr < 0.001). These findings are consistent with a modulating effect of placebo (under analgesic expectation in humans) on a potent nociceptive, pro-inflammatory cytokine (IL-18) and underlying relationships with endogenous opioid activity, a neurotransmitter system critically involved in pain, stress, and mood regulation.