bluuebunny/crossref_metadata_2025_split huggingface dataset:
Signatures of High‐Latitude Waves in Observations of Geomagnetic Acceleration
Authors: Chi‐Durán Rodrigo , Avery Margaret S. , Buffett Bruce A. 
Published: October 2021

AbstractModels for the second time‐derivative of the geomagnetic field reveal prominent activity at high latitudes. Alternating patches of positive and negative geomagnetic acceleration propagate to the west at speeds that exceed nominal fluid velocities in the core. We show that waves are a viable interpretation of these observations. Magnetic Rossby waves produce a high‐latitude response with suitable phase velocities. However, the spatial complexity of the prediction is not compatible with the observations. Our preferred interpretation involves zonal MAC waves. These waves can account for the observed geomagnetic field when a stratified layer exists at the top of the core. The required layer has a thickness in excess of 100 km and a buoyancy frequency comparable to the rotation frequency. We anticipate a gradual reduction in the phase velocity over time, leading to a future change in the propagation direction.
Field‐Aligned and Ionospheric Currents by AMPERE and SuperMAG During HSS/SIR‐Driven Storms
Authors: Pedersen M. N. , Vanhamäki H. , Aikio A. T. , Käki S. , Workayehu A. B. , Waters C. L. , Gjerloev J. W. 
Published: October 2021

AbstractThis study considers 28 geomagnetic storms with Dst nT driven by high‐speed streams (HSSs) and associated stream interaction regions (SIRs) during 2010–2017. Their impact on ionospheric horizontal and field‐aligned currents (FACs) have been investigated using superposed epoch analysis of SuperMAG and AMPERE data, respectively. The zero epoch () was set to the onset of the storm main phase. Storms begin in the SIR with enhanced solar wind density and compressed southward oriented magnetic field. The integrated FAC and equivalent currents maximize 40 and 58 min after , respectively, followed by a small peak in the middle of the main phase ( + 4 hr), and a slightly larger peak just before the Dst minimum ( + 5.3 hr). The currents are strongly driven by the solar wind, and the correlation between the Akasofu and integrated FAC is 0.90. The number of substorm onsets maximizes near . The storms were also separated into two groups based on the solar wind dynamic pressure pdyn in the vicinity of the SIR. High pdyn storms reach solar wind velocity maxima earlier and have shorter lead times from the HSS arrival to storm onset compared with low pdyn events. The high pdyn events also have sudden storm commencements, stronger solar wind driving and ionospheric response at , and are primarily responsible for the first peak in the currents after . After days, the currents and number of substorm onsets become higher for low compared with high pdyn events, which may be related to higher solar wind speed.
Synoptic Mesoscale to Basin Scale Variability in Biological Productivity and Chlorophyll in the Kuroshio Extension Region
Authors: Clayton Sophie , Palevsky Hilary I. , Thompson LuAnne , Quay Paul D. 
Published: October 2021

AbstractThe Kuroshio current separates from the Japanese coast to become the eastward flowing Kuroshio Extension (KE) characterized by a strong latitudinal density front, high levels of mesoscale (eddy) energy, and high chlorophyll a (Chl). While satellite measurements of Chl show evidence of the impact of mesoscale eddies on the standing stock of phytoplankton, there have been very limited synoptic, spatially resolved in situ estimates of productivity in this region. Here, we present underway measurements of oxygen/argon supersaturation (ΔO2/Ar), a tracer of net biological productivity, for the KE made in spring, summer, and early autumn. We find large seasonal differences in the relationships between ΔO2/Ar, Chl, and sea level anomaly (SLA), a proxy for local thermocline depth deviations driven by mesoscale eddies derived from satellite observations. We show that the KE is a pronounced hotspot of high ΔO2/Ar in spring, but corresponding surface Chl values are low and have no correlation with ΔO2/Ar. In summer, there is a hotspot of productivity associated with the Oyashio front, where ΔO2/Ar and Chl are strongly positively correlated. In autumn, ΔO2/Ar and Chl are consistently low throughout the region and also positively correlated. By combining our analysis of the in situ ΔO2/Ar data with complementary Argo, BGC‐Argo, repeat hydrography, and SLA observations, we infer the combination of physical and biological controls that drive the observed distributions of ΔO2/Ar and Chl. We find that the KE and Oyashio currents both act to supply nutrients laterally, fueling regions of high productivity in spring and summer, respectively.
Response of the Upper‐Level Monsoon Anticyclones and Ozone to Abrupt CO2 Changes
Authors: Tweedy Olga V. , Oman Luke D. , Waugh Darryn W. , Schoeberl Mark R. , Douglass Anne R. , Li Feng 
Published: October 2021

AbstractThe summer monsoon anticyclones are the dominant climatological features of the Northern Hemispheric (NH) summertime circulation in the upper troposphere and lower stratosphere (UTLS). However, the response of these anticyclones to the increased levels of remains highly uncertain, as does the impact on the distribution of UTLS ozone and other tracers. This study examines the response of the NH summertime monsoon anticyclones and UTLS ozone to the abrupt increase in forcing using output from a suite of coupled ocean–atmosphere general circulation model simulations. These models show an equatorward shift of the Asian summer monsoon anticyclone, a weakening of the North American summer monsoon anticyclone, and a stronger westerly flow penetrating deep into the tropics above the Pacific Ocean and North America. We use additional idealized experiments from atmosphere‐only general circulation models with prescribed SSTs and sea ice concentration to isolate the direct atmospheric radiative effects from the indirect effect of SST warming on the UTLS monsoon anticyclones. Comparison between atmosphere‐only and coupled ocean–atmosphere experiments shows that SST warming is the principal mechanism producing UTLS monsoonal circulation changes. The experiments result in a significant reduction up to 40%–50% of the UTLS ozone in the northern tropics, which could have an impact on radiative balance near the surface.
Optimizing Carbon Cycle Parameters Drastically Improves Terrestrial Biosphere Model Underestimates of Dryland Mean Net CO2 Flux and its Inter‐Annual Variability
Authors: Mahmud Kashif , Scott Russell L. , Biederman Joel A. , Litvak Marcy E. , Kolb Thomas , Meyers Tilden P. , Krishnan Praveena , Bastrikov Vladislav , MacBean Natasha 
Published: October 2021

AbstractDrylands occupy ∼40% of the land surface and are thought to dominate global carbon (C) cycle inter‐annual variability (IAV). Therefore, it is imperative that global terrestrial biosphere models (TBMs), which form the land component of IPCC earth system models, are able to accurately simulate dryland vegetation and biogeochemical processes. However, compared to more mesic ecosystems, TBMs have not been widely tested or optimized using in situ dryland CO2 fluxes. Here, we address this gap using a Bayesian data assimilation system and 89 site‐years of daily net ecosystem exchange (NEE) data from 12 southwest US Ameriflux sites to optimize the C cycle parameters of the ORCHIDEE TBM. The sites span high elevation forest ecosystems, which are a mean sink of C, and low elevation shrub and grass ecosystems that are either a mean C sink or “pivot” between an annual C sink and source. We find that using the default (prior) model parameters drastically underestimates both the mean annual NEE at the forested mean C sink sites and the NEE IAV across all sites. Our analysis demonstrated that optimizing phenology parameters are particularly useful in improving the model's ability to capture both the magnitude and sign of the NEE IAV. At the forest sites, optimizing C allocation, respiration, and biomass and soil C turnover parameters reduces the underestimate in simulated mean annual NEE. Our study demonstrates that all TBMs need to be calibrated for dryland ecosystems before they are used to determine dryland contributions to global C cycle variability and long‐term carbon‐climate feedbacks.
Effects of River Partial Penetration on the Occurrence of Riparian Freshwater Lenses: Experimental Investigation
Authors: Jazayeri Amir , Werner Adrian D. , Wu Huiqiang , Lu Chunhui 
Published: October 2021

AbstractThis study examines the occurrence of riparian lenses adjacent to partially penetrating, gaining rivers under the controlled conditions of a laboratory sand tank. Laboratory experiments and numerical modeling of the freshwater lens extent are used to provide physical verification (in light of limited examples of well‐characterized field cases) of the analytical methodology, thereby evaluating the underlying assumptions. Parameter calibration and uncertainty analysis are applied to assess both the experimental conditions and the benefit of lens observations in applying the analytical approach. The experimental freshwater lens was reproduced by both analytical and numerical models, with the exception of small mismatches (between analytical results and measured data) in the lens thickness in the near‐river region. These are most likely due to vertical flow effects that arise from the partial river penetration and saltwater inflows to the river bottom, and that are only partly accounted for in the analytical approach. Uncertainty analysis highlighted that accurate lens predictions based on the analytical method requires calibration to direct lens measurements; a similar finding from earlier studies of fully penetrating river conditions. Sensitivity analysis highlighted that the saltwater head boundary, freshwater and saltwater densities, and the aquifer depth below the riverbed (in descending order of sensitivity) are the most important factors in controlling freshwater lens occurrence and saltwater discharge. The results provide the first physical verification of the occurrence of stable riparian lenses adjacent to partially penetrating, gaining rivers, and verify a recent analytical solution for lens extent and saltwater discharge.
The biological applications of DNA nanomaterials: current challenges and future directions
Authors: Ma Wenjuan , Zhan Yuxi , Zhang Yuxin , Mao Chenchen , Xie Xueping , Lin Yunfeng 
Published: October 2021

AbstractDNA, a genetic material, has been employed in different scientific directions for various biological applications as driven by DNA nanotechnology in the past decades, including tissue regeneration, disease prevention, inflammation inhibition, bioimaging, biosensing, diagnosis, antitumor drug delivery, and therapeutics. With the rapid progress in DNA nanotechnology, multitudinous DNA nanomaterials have been designed with different shape and size based on the classic Watson–Crick base-pairing for molecular self-assembly. Some DNA materials could functionally change cell biological behaviors, such as cell migration, cell proliferation, cell differentiation, autophagy, and anti-inflammatory effects. Some single-stranded DNAs (ssDNAs) or RNAs with secondary structures via self-pairing, named aptamer, possess the ability of targeting, which are selected by systematic evolution of ligands by exponential enrichment (SELEX) and applied for tumor targeted diagnosis and treatment. Some DNA nanomaterials with three-dimensional (3D) nanostructures and stable structures are investigated as drug carrier systems to delivery multiple antitumor medicine or gene therapeutic agents. While the functional DNA nanostructures have promoted the development of the DNA nanotechnology with innovative designs and preparation strategies, and also proved with great potential in the biological and medical use, there is still a long way to go for the eventual application of DNA materials in real life. Here in this review, we conducted a comprehensive survey of the structural development history of various DNA nanomaterials, introduced the principles of different DNA nanomaterials, summarized their biological applications in different fields, and discussed the current challenges and further directions that could help to achieve their applications in the future.
Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer
Authors: Zhu Huifang , Su Zijie , Ning Jiong , Zhou Liang , Tan Lifeng , Sayed Sapna , Song Jiaxing , Wang Zhongyuan , Li Huan , Sun Qi , Liu Shanshan , Sha Ou , Leng Feng , Chen Xianxiong , Lu Desheng 
Published: October 2021

AbstractUpregulation of transmembrane protein 97 (TMEM97) has been associated with progression and poor outcome in multiple human cancers, including breast cancer. Recent studies suggest that TMEM97 may be involved in the activation of the Wnt/β-catenin pathway. However, the molecular mechanism of TMEM97 action on Wnt/β-catenin signaling is completely unclear. In the current study, TMEM97 was identified as an LRP6-interacting protein. TMEM97 could interact with LRP6 intracellular domain and enhance LRP6-mediated Wnt signaling in a CK1δ/ε-dependent manner. The binding of TMEM97 to LRP6 facilitated the recruitment of CK1δ/ε to LRP6 complex, resulting in LRP6 phosphorylation at Ser 1490 and the stabilization of β-catenin. In breast cancer cells, knockout of TMEM97 attenuated the Wnt/β-catenin signaling cascade via regulating LRP6 phosphorylation, leading to a decrease in the expression of Wnt target genes AXIN2, LEF1, and survivin. TMEM97 deficiency also suppressed cell viability, proliferation, colony formation, migration, invasion, and stemness properties in breast cancer cells. Importantly, TMEM97 knockout suppressed tumor growth through downregulating the Wnt/β-catenin signaling pathway in a breast cancer xenograft model. Taken together, our results revealed that TMEM97 is a positive modulator of canonical Wnt signaling. TMEM97-mediated Wnt signaling is implicated in the tumorigenesis of breast cancer, and its targeted inhibition may be a promising therapeutic strategy for breast cancer.
A sub-150-nanometre-thick and ultraconformable solution-processed all-organic transistor
Authors: Viola Fabrizio Antonio , Barsotti Jonathan , Melloni Filippo , Lanzani Guglielmo , Kim Yun-Hi , Mattoli Virgilio , Caironi Mario 
Published: October 2021

AbstractRecent advancements in the field of electronics have paved the way to the development of new applications, such as tattoo electronics, where the employment of ultraconformable devices is required, typically achievable with a significant reduction in their total thickness. Organic materials can be considered enablers, owing to the possibility of depositing films with thicknesses at the nanometric scale, even from solution. However, available processes do not allow obtaining devices with thicknesses below hundreds of nanometres, thus setting a limit. Here, we show an all-organic field effect transistor that is less than 150 nm thick and that is fabricated through a fully solution-based approach. Such unprecedented thickness permits the device to conformally adhere onto nonplanar surfaces, such as human skin, and to be bent to a radius lower than 1 μm, thereby overcoming another limitation for field-effect transistors and representing a fundamental advancement in the field of ultrathin and tattoo electronics.
Recycling lead and transparent conductors from perovskite solar modules
Authors: Chen Bo , Fei Chengbin , Chen Shangshang , Gu Hangyu , Xiao Xun , Huang Jinsong 
Published: October 2021

AbstractPerovskite photovoltaics are gaining increasing common ground to partner with or compete with silicon photovoltaics to reduce cost of solar energy. However, a cost-effective waste management for toxic lead (Pb), which might determine the fate of this technology, has not been developed yet. Here, we report an end-of-life material management for perovskite solar modules to recycle toxic lead and valuable transparent conductors to protect the environment and create dramatic economic benefits from recycled materials. Lead is separated from decommissioned modules by weakly acidic cation exchange resin, which could be released as soluble Pb(NO3)2 followed by precipitation as PbI2 for reuse, with a recycling efficiency of 99.2%. Thermal delamination disassembles the encapsulated modules with intact transparent conductors and cover glasses. The refabricated devices based on recycled lead iodide and recycled transparent conductors show comparable performance as devices based on fresh raw materials. Cost analysis shows this recycling technology is economically attractive.
The GPR171 pathway suppresses T cell activation and limits antitumor immunity
Authors: Fujiwara Yuki , Torphy Robert J. , Sun Yi , Miller Emily N. , Ho Felix , Borcherding Nicholas , Wu Tuoqi , Torres Raul M. , Zhang Weizhou , Schulick Richard D. , Zhu Yuwen 
Published: October 2021

AbstractThe recently identified G-protein-coupled receptor GPR171 and its ligand BigLEN are thought to regulate food uptake and anxiety. Though GPR171 is commonly used as a T cell signature gene in transcriptomic studies, its potential role in T cell immunity has not been explored. Here we show that GPR171 is transcribed in T cells and its protein expression is induced upon antigen stimulation. The neuropeptide ligand BigLEN interacts with GPR171 to suppress T cell receptor-mediated signalling pathways and to inhibit T cell proliferation. Loss of GPR171 in T cells leads to hyperactivity to antigen stimulation and GPR171 knockout mice exhibit enhanced antitumor immunity. Blockade of GPR171 signalling by an antagonist promotes antitumor T cell immunity and improves immune checkpoint blockade therapies. Together, our study identifies the GPR171/BigLEN axis as a T cell checkpoint pathway that can be modulated for cancer immunotherapy.
Autoencoder-based detection of the residues involved in G protein-coupled receptor signaling
Authors: Tsuchiya Yuko , Taneishi Kei , Yonezawa Yasushige 
Published: October 2021

AbstractRegulator binding and mutations alter protein dynamics. The transmission of the signal of these alterations to distant sites through protein motion results in changes in protein expression and cell function. The detection of residues involved in signal transmission contributes to an elucidation of the mechanisms underlying processes as vast as cellular function and disease pathogenesis. We developed an autoencoder (AE) based method that detects residues essential for signaling by comparing the fluctuation data, particularly the time fluctuation of the side-chain distances between residues, during molecular dynamics simulations between the ligand-bound and -unbound forms or wild-type and mutant forms of proteins. Here, the AE-based method was applied to the G protein-coupled receptor (GPCR) system, particularly a class A-type GPCR, CXCR4, to detect the essential residues involved in signaling. Among the residues involved in the signaling of the homolog CXCR2, which were extracted from the literature based on the complex structures of the ligand and G protein, our method could detect more than half of the essential residues involved in G protein signaling, including those spanning the fifth and sixth transmembrane helices in the intracellular region, despite the lack of information regarding the interaction with G protein in our CXCR4 models.
Eye-tracking analyses of physician face gaze patterns in consultations
Authors: Jongerius C. , van den Boorn H. G. , Callemein T. , Boeske N. T. , Romijn J. A. , Smets E. M. A. , Hillen M. A. 
Published: October 2021

AbstractFace gaze is a fundamental non-verbal behaviour and can be assessed using eye-tracking glasses. Methodological guidelines are lacking on which measure to use to determine face gaze. To evaluate face gaze patterns we compared three measures: duration, frequency and dwell time. Furthermore, state of the art face gaze analysis requires time and manual effort. We tested if face gaze patterns in the first 30, 60 and 120 s predict face gaze patterns in the remaining interaction. We performed secondary analyses of mobile eye-tracking data of 16 internal medicine physicians in consultation with 100 of their patients. Duration and frequency of face gaze were unrelated. The lack of association between duration and frequency suggests that research may yield different results depending on which measure of face gaze is used. Dwell time correlates both duration and frequency. Face gaze during the first seconds of the consultations predicted face gaze patterns of the remaining consultation time (R2 0.26 to 0.73). Therefore, face gaze during the first minutes of the consultations can be used to predict face gaze patterns over the complete interaction. Researchers interested to study face gaze may use these findings to make optimal methodological choices.
Comprehensive device simulation of 23.36% efficient two-terminal perovskite-PbS CQD tandem solar cell for low-cost applications
Authors: Madan Jaya , Singh Karanveer , Pandey Rahul 
Published: October 2021

AbstractThe major losses that limit the efficiency of a single-junction solar cell are thermalization loss and transmission loss. Thus, to efficiently utilize the full solar spectrum and to mitigate these losses, tandem solar cells (TSC) have significantly impacted the photovoltaic (PV) landscape. In this context, the research on perovskite/silicon tandems is currently dominating the research community. The stability improvements of perovskite materials and mature fabrication techniques of silicon have underpinned the rapid progress of perovskite/silicon TSC. However, the low absorption coefficient and high module cost of the silicon are the tailbacks for the mass production of perovskite/silicon TSCs. Therefore, PV technology demands to explore some new materials other than Si to be used as absorber layer in the bottom cell. Thus, here in this work, to mitigate the aforementioned losses and to reduce cost, a 23.36% efficient two-terminal perovskite-PbS CQD monolithic tandem solar cell has been designed through comprehensive device simulations. Before analyzing the performance of the proposed TSC, the performance of perovskite top cells has been optimized in terms of variation in optical properties, thickness, and interface defect density under standalone conditions. Thereafter, filtered spectrum and associated integrated filtered power by the top cell at different perovskite thickness from 50 to 500 nm is obtained to conceive the presence of the top cell above the bottom cell with different perovskite thickness. The current matching by concurrently varying the thickness of both the top and bottom subcell has also been done to obtain the maximum deliverable tandem JSC for the device under consideration. The top/bottom subcell with current matched JSC of 16.68 mA cm−2/16.62 mA cm−2 showed the conversion efficiency of 14.60%/9.07% under tandem configuration with an optimized thickness of 143 nm/470 nm, where the top cell is simulated under AM1.5G spectrum, and bottom cell is exposed to the spectrum filtered by 143 nm thick top cell. Further, the voltages at equal current points are added together to generate tandem J–V characteristics. This work concludes a 23.36% efficient perovskite-PbS CQD tandem design with 1.79 V (VOC), 16.67 mA cm−2 (JSC) and 78.3% (FF). The perovskite-PbS CQD tandem device proposed in this work may pave the way for the development of high-efficiency tandem solar cells for low-cost applications.