bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Effects of Pterocarpus Soyauxii Against Menopause‐Related NAFLD Based on Network Pharmacology, Molecular Docking, and Experimental Validation
Authors: Emmanuel Owona Pascal , Mengue Yolande , Claude Bilanda Danielle , Ronald Bidingha A Goufani , Vicky Ama Moor , Paul Désiré Dzeufiet Djomeni , Pierre Kamtchouing , Aziz Tariq , S Alamri Abdulhakeem , Alsanie Walaa F , Alhomrani Majid 
Published: February 2025

Pterocarpus soyauxii (P. soyauxii) is a Fabaceae family traditionally used to treat menopausal disorders. This study aims to investigate the effect of P. soyauxii on menopause‐related NAFLD and to determine its mechanisms of action and signaling pathways. In vitro experiments evaluated the antioxidant properties of P. soyauxii. In vivo studies using ovariectomized rat models underlined pathways and effects of P. soyauxii on biochemical and histological features linked with NAFLD. Findings suggest that P. soyauxii compounds are readily absorbed through the intestine and exhibit a relatively low level of toxicity. Protein‐protein interaction, compounds target networks, and KEGG pathway analysis revealed several pathways and target proteins of P. soyauxii compounds. Indeed, they target specific proteins such as ERα/β, NADPH‐O, EGFR, MAPK1, PPARα/G, and HMG‐Co A reductase. Molecular docking revealed that P. soyauxii compounds demonstrate high binding affinity to various proteins. In vitro, P. soyauxii inhibits the oxidative power of OH, H2O2, and NO. In vivo, P. soyauxii significantly (p<0.01, p<0.001, and p<0.01, respectively) reduces ALAT (25.14%), hepatic cholesterol (15.27%), and MDA (26.78%) levels at 200 mg/kg and prevents steatosis in the liver. These findings suggest that P. soyauxii may have a protective role against menopause‐related NAFLD.
First Application of Combined Cutting Balloon and Rotational Atherectomy and Intravascular Lithotripsy in Old Degenerated Saphenous Venous Graft
Authors: Helal Ayman , Cader Aaysha , Hetherington Simon , Hogrefe Kai 
Published: February 2025

ABSTRACTSaphenous venous grafts (SVGs) are prone to progressive degeneration, leading to complex calcified lesions, which present a therapeutic challenge during percutaneous coronary interventions (PCI). Calcium modification techniques such as cutting balloons, intravascular lithotripsy (IVL), and rotational atherectomy have been employed in native coronary arteries; however, the use of rotational atherectomy in SVGs is controversial. This case report presents a novel approach where calcium modification techniques were successfully used to treat calcified stenosis in 30 years old SVG. The case demonstrates safe and effective use of rotational atherectomy in an SVG, possibly making it the first documented application of this technique in such a context. The report explores the rationale, procedural details, and potential risks of this approach, supported by a review of the existing literature.
Determination of Halitosis by Exhaled Breath Analysis Using Semiconductor Metal Oxide Sensors and Chemometric Methods
Authors: Saveliev Mikhail , Volchek Andrey , Lavrenova Galina , Malay Ol'ga , Grevtsev Mikhail , Jahatspanian Igor 
Published: February 2025

ABSTRACTHalitosis is a condition associated with bad breath. Although halitosis is a disease in its own right, it is often a symptom of more serious diseases (diabetes mellitus, renal failure, azotemia, etc.). The currently used method for diagnosing halitosis is the organoleptic method, which relies on a trained specialist evaluating the patient's breath odor. This approach to diagnosing halitosis is subjective, uncomfortable for both patient and doctor, and necessitates the involvement of a specially trained professional. As an alternative, instrumental diagnostics employing metal oxide semiconductor (MOS) sensor arrays offer a promising avenue by enabling patient classification through predeveloped models. This paper considers the application of seven MOS sensors of different compositions at three different temperatures. Different methods of chemometric data analysis were applied: k‐nearest neighbors (kNN), decision trees (DT), support vector machine (SVM), logistic regression (LR), and projection on latent structures discrimination analysis (PLSDA). All applied methods demonstrated their effectiveness and achieved selectivity, sensitivity, and accuracy values exceeding 85%. Additionally, a combined classifier leveraging responses from all previously studied classifiers was explored, achieving near‐perfect classification accuracy.
Energy‐Efficient Fuzzy Logic With Barnacle Mating Optimization‐Based Clustering and Hybrid Optimized Cross‐Layer Routing in Wireless Sensor Network
Authors: Renaldo Maximus A. , Balaji S. 
Published: February 2025

ABSTRACTRecent advancements in information technology have led to the widespread adoption of the Internet of Things (IoT) across various applications. Wireless sensor networks (WSNs), consisting of low‐cost, compact sensors, are crucial for IoT systems, enabling data collection for tasks like surveillance and tracking. A major challenge in WSNs is achieving energy efficiency while extending network lifetime (NLT), necessitating effective clustering and routing strategies. Numerous existing methodologies for energy‐efficient clustering and routing exhibit potential; however, they are hindered by constraints including inadequate adaptability to fluctuating network conditions, suboptimal selection of s cluster heads (CHs), and uneven energy consumption, resulting in diminished network longevity and efficacy. These issues require novel strategies to improve overall performance. To tackle this issues, this research presents a novel hybrid technique combining fuzzy logic with barnacles mating optimization (FL‐BMO) to identify the most optimal CHs by evaluating critical criteria like average sink distance, average intracluster distance, residual energy, and CH balance factor. The FL‐BMO methodology utilizes fuzzy logic to address uncertainties in sensor data, and the BMO algorithm, modeled after barnacle mating patterns, offers a resilient and adaptable optimization process, markedly enhancing energy efficiency and network longevity. In addition, an innovative natural‐inspired hybrid cross‐layer sunflower optimization routing (NiHCLR‐SFO) technique has been introduced that entails optimal routing path selection. This approach balances exploration and exploitation during a route selection process, integrating multiple layers of the network functionality which eventually results in improved routing efficiency and network throughput. Such a hybrid approach has been implemented in MATLAB. The proposed method is compared with fuzzy reinforcement learning based data gathering (FRLDG), neuro‐fuzzy‐emperor penguin optimization (NF‐EPO), bio‐inspired cross‐layer routing (BiHCLR), and fuzzy rule‐based energy‐efficient clustering and immune‐inspired routing (FEEC‐IIR) protocols. From these comparisons, it was observed that the method propagates definite NLT gains reaching 39.74%, 32.92%, 15.95%, and 4.8076%, respectively. The proposed method outperforms the existing approaches (FRLDG, NF‐EPO, FEEC‐IIR, and BiHCLR) across several performance parameters: 99% packet delivery ratio (PDR), 2.8 ms of end‐to‐end delay time (E2ED), 1 Mbps of throughput, 30 mJ of energy consumption, 6000 rounds NLT, 2% bit error rate (BER), 1.25 buffer occupancy ratio, and 0.5% of packet loss ratio (PLR).
Enhanced Particle Trap: Design and Simulation of Pillar‐Based Contactless Dielectrophoresis Microfluidic Devices
Authors: Torky Harchegani Peyman , Mashhadi Keshtiban Mohsen , Moghimi Zand Mahdi , Azizi Zahra 
Published: February 2025

ABSTRACTContactless and conventional dielectrophoresis (DEP) microfluidic devices are extensively utilized in lab‐on‐a‐chip applications, particularly for cell isolation and analysis. Nonetheless, these devices typically operate at low throughput and require high applied voltages, posing limitations for microfluidic cell isolation and separation. Addressing these challenges, this study explores the utilization of diverse micro‐pillar geometries within the microfluidic device to augment THP‐1 cell trapping efficiency numerically using FEM modeling. Furthermore, the simulations examine the influence of pillar gap and quantity on cell trapping efficiency in a contactless DEP device. Notably, elliptical pillars demonstrate superior cell trapping efficiency at elevated flow rates compared to alternative configurations, making the microchip more amenable for high‐throughput cell separation, trapping, and isolation applications. Remarkably, employing elliptical pillars in a contactless DEP microfluidic chip yields nearly 100% cell trapping efficiency at higher flow rates. Ellipse configuration showed 122% higher cell trap efficiency at the maximum flowrate compare to the previous study with circular configuration. Additionally, it is observed that reducing the gap between pillars correlates with enhanced cell trapping efficiency. Simulation outcomes indicate that employing two rows of elliptical pillars with a 40‐µm gap achieves optimal performance. The findings of this investigation underscore the importance of pillars in contactless DEP devices and provide valuable insights for future designs of such microfluidic devices.
Sensory Lexicon Construction and Quantitative Descriptive Analysis of Jiang‐Flavor Baijiu
Authors: Niu Junjie , Yang Yubo , Zhao Lei , Cao Nian , Xiong Xiaolin , Yun Zhenyu , Yang Fan , Xu Yang , Tu Huabin , Zhong Kui , Wang Houyin , Gao Haiyan , Zhang Yao , Qin Zhen , Wang Li , Shi Bolin 
Published: February 2025

ABSTRACTJiang‐flavor Baijiu (JFB) is one of the most complex and representative types of traditional Chinese liquor, known for its unique flavor, which is popular among Chinese consumers. Previous studies primarily focused on detecting and identifying volatile compounds but lacked comprehensive descriptions and precise differentiation of their sensory qualities. To explore the sensory characteristics of JFB, this study collected widely recognized sensory descriptors from literature, standards, free descriptive questionnaires, and Pivot Profile experiments, which were then textually analyzed and merged to yield 88 sensory descriptors. M‐value and multivariate statistical methods were then used to narrow these down to 35 sensory descriptors, for which corresponding definitions and physical references were established, forming a sensory lexicon for JFB. A quantitative descriptive analysis (QDA) was performed on JFB samples using the sensory lexicon. To ensure the reliability of the analysis, the panel's performance was also evaluated. Hierarchical cluster analysis (HCA), radar plots, and one‐way analysis of variance (ANOVA) demonstrated that the established sensory lexicon accurately reflects the sensory profile of JFB and can be used to differentiate the sensory characteristics of samples from different price ranges or regions. This study opens new avenues for the standardization of quantitative descriptive analysis for JFB and provides a case study for constructing sensory lexicons for other types of Baijiu in China.
Study of the Chemical Characteristics of Salt in Soil and Drainage Water Under Subsurface Drainage and Leaching Conditions
Authors: Qian Yingzhi , Han Xudong , Zhu Yan , He Shuai , Huang Jiesheng 
Published: February 2025

ABSTRACTIn arid regions, intensive phreatic evaporation plays a significant role in promoting soil salinisation. Subsurface drainage is widely used to mitigate this issue. However, most previous studies focused on total salt and neglected the varying transport capacities of individual components. Studying salt in soil and drainage water from the perspective of salt components and their chemical species is essential. In this study, field experiments under subsurface drainage were conducted, and the contents of major salt components were monitored. The PHREEQC 3.0 model was used to calculate the chemical species contents. Leaching efficiency was quantified via the leaching ratio and critical leaching depth. The results showed that Cl and Na presented the highest leaching efficiencies, which are low for Ca, as 90% of Ca existed in the form of a CaSO4·2H2O precipitate. The leaching efficiencies of SO4 and Mg were sensitive to the irrigation quota, resulting from the high sensitivities of their main species, MgSO40 and SO42−, to the irrigation quota. The constitutions of the salt in the drainage water were closer to those in the groundwater because the drainage water mainly originates from the groundwater. This study provides guidance for determining appropriate design parameters for subsurface pipes and leaching quotas.
Utilization of Bulk RNA Sequencing for the Evaluation of Keratin Nanomaterials as a Coating for Percutaneous Devices
Authors: Miller Andrew , Beck James Peter , White Alexis , Agarwal Jayant , Bachus Kent N. , Jeyapalina Sujee , Van Dyke Mark 
Published: February 2025

ABSTRACTDespite advances in the design and protocols for maintaining the skin/device interface around percutaneous devices (PDs), no current strategy ensures the permanent attachment of peri‐implant epithelial tissue to the device surface. Based on preliminary data, we hypothesized that PDs coated with keratin nanomaterials, resembling the fingernail‐nailbed interface, could provide a biochemically mediated surface that enhances epidermal cell adhesion and differentiation. To test this hypothesis, 15 Yucatan miniature pigs were each implanted with six percutaneous titanium devices, comprising three porous and three smooth devices, both with and without keratin coatings (Kerateine [iKNT] and Keratose [gKOS]). The pigs were sacrificed at 4, 8, and 16 weeks post‐implantation. The devices and surrounding tissues were harvested and analyzed using histological and RNA sequencing techniques. Compared to smooth peri‐implant tissue, porous peri‐implant tissue showed a significant decrease in epithelial downgrowth, fibrous capsule thickness, and infection rates, alongside a significant upregulation of multiple immune marker genes, including IL12B. At the 16‐week period, gKOS‐coated surfaces demonstrated a more favorable wound healing response than iKTN‐coated devices, with a reduction in granulation tissue area and a significant upregulation of several keratin genes related to differentiation. Among the combinations of surface types and coatings studied, the porous gKOS‐coated device produced the most favorable wound healing response.
Therapeutic Plasma Exchange in Tandem With Other Types of Extracorporeal Circuits: The Experience of a Pediatric Center and a Review of Other Pediatric Center Reports
Authors: Aplenc Lejla Music , Wood Nicole , Iqbal Nazia Tabassum , George Cindy , Burroughsscanlon Cherie 
Published: February 2025

ABSTRACTTherapeutic plasma exchange (TPE) concurrently performed in critically ill pediatric patients with other extracorporeal circuits is a complex process. We sought to characterize tandem procedures, including patient demographics, primary diagnosis, American Society for Apheresis (ASFA) category indications, survival at 24 h and 30 days after completion, blood product utilization, and complications. A retrospective analysis of medical records was performed. Data were collected from July 2014 to January 2021 with institutional review board approval. Patients' demographics, blood product utilization, and adverse events data were collected. In addition, we performed a literature review to identify studies in the pediatric population that were similar in design to our study. Fifty patients underwent 262 procedures. The median age was 9 years, and median weight was 21 kg (42% of patients weighed less than 10 kg). The most frequent indications for plasma exchange included sepsis with multiorgan failure (11 patients) and multiorgan failure (9 patients). ASFA indication category III was the most common (42 patients), followed by uncategorized indications (6 patients). The most common adverse events were hypocalcemia, occurring in 120 (45%) procedures, hypotension in 25 (9.5%) procedures, and circuit clotting in 12 (4.5%) procedures. Citrate, heparin, and bivalirudin were used as anticoagulants. Thirty‐nine (78%) patients survived 24 h, and 26 (52%) patients were alive 30 days after completion of tandem procedures. Despite the high level of complexity, tandem procedures can be performed efficiently and safely in critically ill children.
Evaluation and Remediation Strategies for Struggling Residents Within Oral & Maxillofacial Surgery Residency Programs
Authors: Daley Samuel J , DMD Syed Raza , Martin Hunter J , Segal Joshua D , Salama Andrew R 
Published: February 2025

ABSTRACTPurpose/ObjectivesSeveral studies have evaluated resident and trainee remediation strategies across various surgical subspecialties. However, limited research exists on this topic within the Oral and Maxillofacial Surgery (OMS) literature. The purpose of this study was to identify cross‐sectional patterns of evaluation and remediation strategies for underperforming OMS residents in the United States.MethodsA cross‐sectional cohort study was conducted using a 22‐question survey administered to OMS residency Program Directors of all programs approved by the Commission on Dental Accreditation (CODA) within the United States. The predictor variables included the demographics and resident assessment methods of responding programs. The outcome variables included the results of remediation strategies and corrective action plans for residents identified as struggling over the preceding 10 years. Responses were anonymized, and descriptive statistics were used to analyze the collected data.ResultsCompleted surveys were obtained from 29 (29%) CODA‐approved programs. Twenty‐five of 29 (86%) programs reported placing 64 residents on corrective action plans. Nine of 29 (31%) programs reported that 14 residents were dismissed during that period. The most common deficiencies in residents requiring corrective action plans were cognitive skills (37.9%), clinical skills (20.7%), and interpersonal skills (20.7%). Residents were almost always given a warning prior to initiating remediation or probation (96.6%), with verbal (46.4%) and written (53.4%) warnings being used with nearly equivalent frequency. Remedial action most often included general counseling (15.9%), more frequent feedback sessions (15.9%), assignment of a mentor (15.2%), didactic remediation (13.3%), psychiatric/psychologic counseling (11.26%), and lengthened training time (6.6%). Most programs reported utilization of a formal remediation protocol (75.9%) and 85.7% of programs subjectively felt their process was effective. Almost one‐quarter of respondents (24.1%) stated that no formal remediation protocol exists at their institution.ConclusionsMost OMS programs utilized some form of remediation protocols, but their usage was inconsistent and infrequent. The evaluation and remediation processes among OMS residency programs have significant variability, relying heavily on program or institution‐specific protocols.
Paternal Split‐Liver Transplantation Followed by Haploidentical Hematopoietic Cell Transplantation in an Adult Patient With Protoporphyria‐Induced Liver Failure
Authors: Stölzel Ulrich , Jost Lasse , Seehofer Daniel , Egger‐Heidrich Katharina , Scheuermann Uwe , Hölig Kristina , Stauch Thomas , Kunadt Desiree , Schuppan Detlef , Schetelig Johannes , Wohmann Nils , Bornhäuser Martin , Stölzel Friedrich 
Published: February 2025

ABSTRACTIntroductionErythropoietic Protoporphyria (EPP) caused skin light sensitivity and liver cirrhosis in a 35‐year‐old patient who subsequently developed liver‐failure.MethodsIn absence of a human leukocyte antigens (HLA)‐matched‐unrelated donor, the father consented in donating for split liver transplantation (SLT) and allogeneic hematopoietic cell transplantation (HCT).ResultsAfter bridging therapy and successful SLT a first paternal HCT resulted in graft failure. For a second haploidentical HCT a different regimen was applied leading to engraftment while protoporphyrin (PP) blood‐levels decreased to normal and skin light sensitivity skin disappeared, leading to complete remission in an immunosuppressive‐free patient.ConclusionHaploidentical transplantation is a feasible treatment approach in EPP‐patients.Trial RegistrationThe authors have confirmed clinical trial registration is not needed for this submission
Characteristics of Human Papillomavirus Prevalence and Infection Patterns Among Women Aged 35–65 in Fujian Province, China: A Nine‐Year Retrospective Observational Study
Authors: Lu Zhen , Dong Binhua , Yao Peng , Huang Ying , Fu Leiwen , Wang Bingyi , Huang Xinxin , Mao Xiaodan , Xu Shuxia , Liu Siyang , Sun Pengming , Zou Huachun 
Published: February 2025

ABSTRACTThe assessment of human papillomavirus (HPV) genotype distribution could inform targeted cervical cancer prevention strategies. The epidemiology of HPV genotypes in terms of age and cervical lesions in Fujian Province, China has not been well described. This 9‐year retrospective study aimed to delineate the prevalence pattern and trend of HPV genotypes among a large‐scale community‐based population. Deidentified data were retrieved from the national cervical cancer screening program in China. We included eligible women aged 35–65 years who underwent cervical cancer screening between 2014 and 2022 in Fujian Province. The HPV prevalence within distinct subpopulations was calculated, and trends in HPV prevalence over the years and across age groups were examined using the Cochran‐Armitage trend test. A total of 551 604 women (median age 49 years [42, 54]; 0.10% with cervical cancer) were included in this study. The overall HPV prevalence was 11.72% (95% CI: 11.63%–11.80%), with HR‐HPV (high‐risk HPV) and HPV 16/18 prevalence at 10.02% (9.94%–10.10%) and 1.74% (1.71%–1.78%), respectively. HPV‐52, 58, 16, 39, 51, and 68 were the most predominant genotypes in the general population. Nearly all genotypes, except for HPV‐39 and 66, showed a decreasing trend in prevalence over the years, while a relatively high prevalence of HR‐HPV was observed across all age groups. As lesion severity increased, HR‐HPV and 9v‐HPV prevalence also increased. Our study underscores the importance of ongoing surveillance of HPV prevalence in China. While the overall decline in HPV infections over the years is encouraging, the relatively high prevalence of HR‐HPV warrants continued attention. Strengthening public health strategies—including prioritizing and promoting the current 9‐valent vaccination, extending HPV testing and cervical cancer screening to older women where feasible, and developing future vaccines targeting more HR‐HPV genotypes—will be crucial in eliminating cervical cancer and HPV‐related disease in China and beyond.