bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of lesion characteristics between conventional and high-power short-duration ablation using contact force-sensing catheter in patients with paroxysmal atrial fibrillation
Authors: Chen Chun-Chao , Lee Po-Tseng , Van Ba Vu , Chuang Chieh-Mao , Lin Yenn-Jiang , Lo Li-Wei , Hu Yu-Feng , Chung Fa-Po , Lin Chin-Yu , Chang Ting-Yung , Vicera Jennifer Jeanne , Huang Ting-Chun , Liu Chih-Min , Wu Cheng-I , Lugtu Isaiah C. , Jain Ankit , Chang Shih-Lin , Chen Shih-Ann 
Published: August 2021

Abstract
Background
Transmural lesion creation is essential for effective atrial fibrillation (AF) ablation. Lesion characteristics between conventional energy and high-power short-duration (HPSD) setting in contact force-guided (CF) ablation for AF remained unclear.

Methods
Eighty consecutive AF patients who received CF with conventional energy setting (power control: 25–30 W, force–time integral = 400 g s, n = 40) or with HPSD (power control: 40–50 W, 10 s, n = 40) ablation were analyzed. Of them, 15 patients in each conventional and HPSD group were matched by age and gender respectively for ablation lesions analysis. Type A and B lesions were defined as a lesion with and without significant voltage reduction after ablation, respectively. The anatomical distribution of these lesions and ablation outcomes among the 2 groups were analyzed.

Results
1615 and 1724 ablation lesions were analyzed in the conventional and HPSD groups, respectively. HPSD group had a higher proportion of type A lesion compared to conventional group (P < 0.01). In the conventional group, most type A lesions were at the right pulmonary vein (RPV) posterior wall (50.2%) whereas in the HPSD group, most type A lesions were at the RPV anterior wall (44.0%) (P = 0.04). The procedure time and ablation time were significantly shorter in the HPSD group than that in the conventional group (91.0 ± 12.1 vs. 124 ± 14.2 min, P = 0.03; 30.7 ± 19.2 vs. 57.8 ± 21 min, P = 0.02, respectively). At a mean follow-up period of 11 ± 1.4 months, there were 13 and 7 patients with recurrence in conventional and HPSD group respectively (P = 0.03).

Conclusion
Optimal ablation lesion characteristics and distribution after conventional and HPSD ablation differed significantly. HPSD ablation had shorter ablation time and lower recurrence rate than did conventional ablation.
“OPTIONS-DC”, a feasible discharge planning conference to expand infection treatment options for people with substance use disorder
Authors: Sikka Monica K. , Gore Sara , Vega Taylor , Strnad Luke , Gregg Jessica , Englander Honora 
Published: August 2021

Abstract
Background
Serious bacterial infections associated with substance use often result in long hospitalizations, premature discharges, and high costs. Out-of-hospital treatment options in people with substance use disorder (SUD) are often limited.

Methods
We describe a novel multidisciplinary and interprofessional care conference, “OPTIONS-DC,” to identify treatment options agreeable to both patients and providers using the frameworks of harm reduction and patient-centered care. We retrospectively reviewed charts of patients who had an OPTIONS-DC between February 2018 and July 2019 and used content analysis to understand the conferences’ effects on antibiotic treatment options.

Results
Fifty patients had an OPTIONS-DC during the study window. Forty-two (84%) had some intravenous (IV) substance use and 44 (88%) had an active substance use disorder. Participants’ primary substances included opioids (65%) or methamphetamines (28%). On average, conferences lasted 28 min. OPTIONS-DC providers recommended out-of-hospital antibiotic treatment options for 34 (68%) of patients. OPTIONS-DC recommended first line therapy of IV antibiotics for 35 (70%) patients, long-acting injectable antibiotics for 14 (28%), and oral therapy for 1 (2%). 35 (70%) patients that had an OPTIONS-DC completed an antibiotic course and 6 (12%) left the hospital prematurely. OPTIONS-DC expanded treatment options by exposing and contextualizing SUD, psychosocial risk and protective factors; incorporating patient preferences; and allowing providers to tailor antibiotic and SUD recommendations.

Conclusions
OPTIONS-DC is a feasible intervention that allows providers to integrate principles of harm reduction and offer patient-centered choices among patients needing prolonged antibiotic treatment.
Human immune deficiency virus among cervical cancer patients at Tikur Anbessa Specialized Hospital, Ethiopia: a cross sectional study
Authors: Wassie Mulugeta , Fentie Beletech , Asefa Tseganesh 
Published: August 2021

AbstractBackgroundThe discrepancy in cervical cancer incidence between women with HIV and women without HIV is highest in low and middle-income countries. In Africa, cervical cancer is the most common cause of cancer death. As a result, HIV-infected women are 6 times more likely to develop cervical cancer than uninfected women. In addition, HIV is associated with several triggering factors for cervical cancer, including multiple sexual partners, early sexual debut, economic status and substance use.ObjectiveTo assess the prevalence and associated factors of HIV among cervical cancer patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.MethodsA cross sectional study was conducted among 1057 cervical cancer patients registered from January 1, 2014 to December 31, 2018 at Oncology Center of Tikur Anbessa Specialized Hospital. A structured English version checklist was used to collect the data from patient charts. The pre coded data were entered in to EPI-data version 3.1 then exported to STATA version 14.0 for analysis. Both bivariable and multivariable regression analysis were carried out. Variables withpvalue < 0.05 in multivariable logistic regression were consider as significant predictors of the outcome variable.ResultThe prevalence of HIV among cervical cancer patients was 18.35%. HIV among cervical cancer patients was significantly associated with age group 30–39 [AOR = 2.83; 95%CI (1.27, 6.22)] and 40–49 [AOR = 2.39; 95%CI (1.07, 5.32)], employed [AOR = 2.23; 95%CI (1.46, 3.41)] and substance users [AOR = 3.92; 95%CI (2.04, 6.28)].ConclusionThis study revealed that about 18% of cervical cancer patients were HIV seropositive. HIV seropositivity was significantly increased with 30–49 age group, employed and substance users. Authors recommended that it is better to screen all HIV seropositive patients for cervical cancer and give greater attention for women with cervical cancer in the age groups of 30–49 years, employed and substance users.
ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis
Authors: Zheng Lei , Xu Hongmei , Di Ya , Chen Lanlan , Liu Jiao , Kang Liying , Gao Liming 
Published: August 2021

Abstract
Background
We tried to elaborate the molecular mechanism of ETS-like transcription factor 4 (ELK4) affecting gastric cancer (GC) progression through M2 polarization of macrophages mediated by lysine-specific demethylase 5A (KDM5A)-Praja2 (PJA2)-kinase suppressor of ras 1 (KSR1) axis.

Methods
GC expression dataset was obtained from GEO database, and the downstream regulatory mechanism of ELK4 was predicted. Tumor-associated macrophages (TAMs) were isolated from GC tissues. The interaction among ELK4, KDM5A, PJA2 and KSR1 was analyzed by dual luciferase reporter gene, ChIP and Co-IP assays. The stability of KSR1 protein was detected by cycloheximide (CHX) treatment. After TAMs were co-cultured with HGC-27 cells, HGC-27 cell biological processes were assessed through gain- and loss-of function assays. Tumorigenicity was detected by tumorigenicity test in nude mice.

Results
In GC and TAMs, ELK4, KDM5A and KSR1 were highly expressed, while PJA2 was lowly expressed. M2 polarization of macrophages promoted the development of GC. ELK4 activated KDM5A by transcription and promoted macrophage M2 polarization. KDM5A inhibited the expression of PJA2 by removing H3K4me3 of PJA2 promoter, which promoted M2 polarization of macrophages. PJA2 reduced KSR1 by ubiquitination. ELK4 promoted the proliferative, migrative and invasive potentials of GC cells as well as the growth of GC xenografts by regulating KSR1.

Conclusion
ELK4 may reduce the PJA2-dependent inhibition of KSR1 by transcriptional activation of KDM5A to promote M2 polarization of macrophages, thus promoting the development of GC.
Percepções sobre a importância da educação interprofissional na formação dos profissionais de saúde: relato de experiência de um grupo do PET–Saúde/Interprofissionalidade
Authors: Lima Witória Lúcia dos Santos , Torreão Priscila Alves , Santos Joice Silva , Cunha Karina Maia , Nascimento Rita de Cássia de Sousa , Anunciação Leilane Lacerda , Coutinho Naluse Anne Silva 
Published: August 2021

O processo de educação interprofissional em saúde acontece quando duas ou mais profissões trabalham em conjunto, aprendendo entre si, com a outra e sobre a outra. Com o intuito de desenvolver o trabalho colaborativo e almejando melhorias na qualidade da assistência em saúde, especialmente no que tange ao contexto do Sistema Único de Saúde (SUS), o Programa de Educação para o Trabalho em Saúde (PET-Saúde), articulado com instituições de ensino superior e instituições públicas de saúde, prepara e forma profissionais com a atenção voltada para o trabalho coletivo em serviços do SUS. Para que isso de fato aconteça, leva-se em consideração a realidade e necessidade de saúde de uma dada regiãoonde esses profissionais vão atuar diretamente, bem como, uma sólida formação metodológica prévia sobre o assunto. Este relato de experiência demonstra a contribuição do PET-Saúde na formação de estudantes de diversas áreas da saúde daUniversidade Estadual de Feira de Santana e no desenvolvimento de ações práticas frente a uma dada comunidade, ações essas fundamentadas nos princípios da interprofissionalidade e do trabalho em equipe. AbstractThe process of interprofessional health education happens when two or more professions work together, learning among themselves, with the other and about the other. In order to develop collaborative work and aiming for improvements in the quality of health care, especially with regard to context of Unified Health System, the Education Program for Health Work (EPHW), articulated with health institutions, prepares and trains professionals with a focus on collective work in these services. For this actually happen, the reality and the health needs of a given region, where these professionals will work directly, are taken into account, as well as a solid prior methodological training on the subject. This experience report demonstrates the contribution of EPHW/Interprofessionality in the training of students from different areas of health by the State University of Feira de Santana and in the development of practical actions before a given community. These actions are based on the principles of interprofessionality and team work.
Separating disease and health for indirect reference intervals
Authors: Sikaris Kenneth A. 
Published: August 2021

Abstract
The indirect approach to defining reference intervals operates ‘a posteriori’, on stored laboratory data. It relies on being able to separate healthy and diseased populations using one or both of clinical techniques or statistical techniques. These techniques are also fundamental in a priori, direct reference interval approaches. The clinical techniques rely on using clinical data that is stored either in the electronic health record or within the laboratory database, to exclude patients with possible disease. It depends on the investigators understanding of the data and the pathological impacts on tests. The statistical technique relies on identifying a dominant, apparently healthy, typically Gaussian distribution, which is unaffected by the overlapping populations with higher (or lower) results. It depends on having large databases to give confidence in the extrapolation of the narrow portion of overall distribution representing unaffected individuals. The statistical issues involved can be complex, and can result in unintended bias, particularly when the impacts of disease and the physiological variations in the data are under appreciated.
Anthropomorphic Symbols on Neolithic Vessels from Puglia
Authors: Aprile Giorgia , Tiberi Ida 
Published: August 2021

Abstract
In Puglia, human representations on vessels were widespread from the Early Neolithic. Some of these have been interpreted as faces, but they could also be representations of the entire body complete with torso, arms and legs: these include some recently studied symbols from Grotta dei Cervi, which have been compared with others from Grotta delle Veneri, whose published descriptions are open to revision. From this starting point, the scope of the research was expanded to include all documented anthropomorphic symbols on Neolithic vessels from south-east Italy, taking account of their chronology, origin and context. It was possible to establish that in the sixth millennium BC, there were three different categories of human representation in Puglia: vessels decorated with human faces (face vessels), vessels decorated with whole-body human figures and vessels in the shape of human beings (anthropomorphic vessels). Some faces include all elements, while others have just some of them (e.g. the nose). In addition, some faces have extra elements such as bands or bundles of lines that can be interpreted as tattoos, beards, ornaments or clothes. The symbols may be representations of praying figures, dancers, high status or powerful members of the community, ancestors and even gods, who were tasked with either protecting the community or acting as an intermediary between the community offering the vessel and the deity of the underworld. This study examines the presence of these artefacts in settlements, caves and other cult sites, with the aim of describing this distinctive phenomenon that was particularly characteristic of Puglia during the Early Neolithic.
Формирование кроны кедра сибирского за 12-летний период после декапитации (пригородная зона г. Красноярска)
Authors: Grishlov Dmitriy , Bratilova Natalia , Matveeva Rimma , Butorova Olga 
Published: August 2021

Показаны особенности формирования кроны кедра сибирского (Pinus sibirica Du Tour) после декапитации, произрастающего на плантации «Метеостанция» в Учебно-опытном лесхозе Караульного лесничества в условиях юга Средней Сибири. Объектом исследований являлась 54-летняя плантация кедра сибирского, выращенная из семян, заготовленных в 1964 г. в Лениногорском лесхозе (Республика Казахстан). Декапитация проведена у деревьев 42-летнего возраста в 2005 г. с оставлением ствола высотой 1,4-1,7 м. Верхняя часть кроны удалена на 50,0-66,7%. В 2017 г. деревья достигли высоты 5,6-9,1 м. Количество лидирующих побегов, заменивших центральный, составило 3-7 шт., длина которых за 12-летний период достигла 4,0-7,6 м. Деревья с диаметром ствола 12-18 см имели по 3-4, с диаметром 20-26 см – по 6-7 шт. лидирующих побега. Установлено, что уровень изменчивости высоты деревьев низкий; прироста побегов, диаметра ствола – средний, количества лидирующих побегов – высокий. Наибольшей высотой (9,1 м) отличалось дерево № 4-98, превосходя другие особи на 8,3-62,5%. Сопоставлено количество боковых ветвей, образовавшихся на лидирующих побегах за 5 лет (2013-2017 гг.). Отмечено, что их средний прирост за исследуемый период находился в пределах 23,6-45,5 см. Между диаметром ствола и числом лидирующих побегов коэффициент корреляции (r) равен 0,619; числом лидирующих побегов и количеством сформированных боковых ветвей спустя 7-12 лет после декапитации – 0,770, диаметром ствола при обрезке и высотой деревьев после 12 лет декапитации – 0,738.
Стиглі букові деревостани у різних категоріях лісів рівнинної частини України
Authors: Myklush Stepan , Myklush Yuriy , Havryliuk Serhii , Debryniuk Iurii , Savchyn Volodymyr 
Published: August 2021

За матеріалами обліку лісового фонду визначено площі стиглих букових насаджень у виділених лісовпорядкуванням 21 категорії лісів та лісових ділянок. Встановлено, що понад 57% стиглих деревостанів за площею зосереджено в експлуатаційних лісах та 15,7% – у лісогосподарській частині зелених зон. Стиглі букові насадження ростуть у букових, дубових, ялицевих та соснових типах лісу, але переважають в умовах свіжої грабової бучини займаючи понад 10 тис. га та вологої грабової бучини – 8,5 тис га. Насадження формуються за частки бука лісового у складі від 2 до 10 одиниць. В окремих регіонах поряд з буком у складі беруть участь дуб звичайний, ялиця біла, сосна звичайна, а супутниками найчастіше є граб звичайний, клени явір та гостролистий, береза повисла, осика. В експлуатаційних лісах зосереджено понад 52% чистих за складом деревостанів як за площею так і за кількістю ділянок. Найпоширенішими є насадження з відносною повнотою 0,5, що охоплюють площу майже 7,4 тис. га (1762 ділянки) та з повнотою 0,7, площа яких 7,3 тис. га, і які ростуть на 1150 ділянках. Найвищою продуктивністю стиглі букові лісостани характеризуються в лісогосподарській частині лісів зелених зон, де їхні запаси в окремих насадженнях сягають 590-661 м3∙га-1.
Виконання буковими насадженнями різнопланових функцій потребує застосування лісогосподарських заходів, які найповніше відповідають меті господарювання, постійному збереженню лісового середовища, посиленню виконання насадженнями визначених функцій, вчасному та якісному природному відновленню лісових ділянок. У більшості категорій лісів і лісових ділянок, зокрема, у рекреаційно-оздоровчих лісах і лісах, що виконують екологічні та охоронні функції, вимагається здійснення заходів для поступового переформування одновікових букових лісостанів у різновікові складної структури.
Relationship between Information Skills and Antiretroviral Adherence in People Living With HIV/AIDS
Authors: Lailiah Novianti , Nursalam Nursalam , Kurniawati Ninuk Dian 
Published: August 2021

Introduction: Adherence in ARV therapy is an important mechanism in preventing drug resistance. The level of adherence is influenced by several factors, one of which is the information skills factor. This study aims to analyze the relationship between information skills and ARV adherence in People Living With HIV/AIDS (PLWHA).Method: This was a cross-sectional approach with a sample size of 100 respondents who were selected through simple random sampling technique. The inclusion criteria for respondents were PLWHA who were undergoing ARV therapy, cooperative, aged 20-60 years. The instrument used was information skills questionnaire and Medical Adherence Rating Scale (MARS). The data were analyzed using descriptive analysis and logistic regression test with p value ≤ 0.05.Results: Information skills were associated with ARV adherence (p = 0.01). Information skills consisting of knowledge about HIV/AIDS and ARV therapy can increase ARV adherence in PLWHA with indicators taking drugs regularly and have medical control on schedule.Conclusions: The information skills factor has an effect on ARV adherence. Increasing information skills can be done through educational activities or peer-group support aimed at gaining insight into disease and treatment, especially for newly diagnosed PLWHA.
Alleviating oxidative damage-induced telomere attrition: a potential mechanism for inhibition by folic acid of apoptosis in neural stem cells
Authors: Li Zhenshu , Li Wen , Zhou Dezheng , Zhao Jing , Ma Yue , Huang Ling , Dong Cuixia , Wilson John X. , Huang Guowei 
Published: August 2021

Abstract
DNA oxidative damage can cause telomere attrition or dysfunction that triggers cell senescence and apoptosis. The hypothesis of this study is that folic acid decreases apoptosis in neural stem cells (NSCs) by preventing oxidative stress-induced telomere attrition. Primary cultures of NSCs were incubated for 9 days with various concentrations of folic acid (0 - 40 µM ) and then incubated for 24 h with a combination of folic acid and an oxidant (100 µM hydrogen peroxide, H 2 O 2 ), antioxidant (10 mM N-acetyl-L-cysteine, NAC) or vehicle. Intracellular folate concentration, apoptosis rate, cell proliferative capacity, telomere length, telomeric DNA oxidative damage, telomerase activity, intracellular reactive oxygen species (ROS) levels, cellular oxidative damage, and intracellular antioxidant enzyme activities were determined. The results showed that folic acid deficiency in NSCs decreased intracellular folate concentration, cell proliferation, telomere length and telomerase activity, but increased apoptosis, telomeric DNA oxidative damage and intracellular ROS levels. In contrast, folic acid supplementation dose-dependently increased intracellular folate concentration, cell proliferative capacity, telomere length and telomerase activity but decreased apoptosis, telomeric DNA oxidative damage and intracellular ROS levels. Exposure to H 2 O 2 aggravated telomere attrition and oxidative damage whereas NAC alleviated the latter. High doses of folic acid prevented telomere attrition and telomeric DNA oxidative damage by H 2 O 2 . In conclusion, inhibition of telomeric DNA oxidative damage and telomere attrition in NSCs maybe potential mechanisms of inhibiting NSCs apoptosis by folic acid.
A Game Theoretic Model For Cellular Network Operators’ Cooperation Under Government Intervention
Authors: Fander Atieh , Yaghoubi Saeed , Tajik Javad 
Published: August 2021

Abstract
In the digital world today, cellular networks and their operators play a competitive and important role in communications. The basis of the competition of operators, the quality of provided services, and the coverage level of their antennas, thereby attract customers. This paper studies cellular networks with two old and new operators and under the influence of government intervention in one area. Due to the high cost of building an antenna, the new operator participates in the cost of the infrastructure of the old operator to use the services of these antennas for their customers. On the other hand, the government considers incentive schemes to support mobile operators. The government plan is that he takes part in the infrastructure cost of the old operator and will receive it an income tax; to support the new operator declare it exempt from tax. The government subsidy contract with the old operator is based on the coverage level of the antenna and supports the operator to increase the coverage level. Some numerical examples for Iranian telecommunication companies are applied to examine the applicability of the proposed models. Finally, sensitivity analysis on the main parameters is analyzed in-depth to extract some managerial implications.