bluuebunny/crossref_metadata_2025_split huggingface dataset:
Putting the cart (antecedents) before the horse (absorptive capacity): the role of competitive antecedents to the absorptive capacity innovation process
Authors: Ng Desmond , Sanchez-Aragon Leonardo F. 
Published: December 2021

Purpose
The purpose of this study is to theoretically and empirically advance a concept of competitive antecedents to absorptive capacity (AC) research and to explain their relationship to a firm’s innovative performance. A firm’s competitive antecedents involve a relative advantage in a firm’s ability to access external knowledge – (i.e. relative advantage in external knowledge flows) – and a relative advantage in appropriating these external knowledge flows (i.e. relative advantage in appropriability regime).

Design/methodology/approach
By drawing on network and market share explanations, hypotheses were developed in which a firm’s AC is argued to mediate the influence of these competitive antecedents on a firm’s innovations. In using linear and negative binomial estimation methods, a mediation analysis of the US biotechnology industry was conducted.

Findings
A firm’s competitive antecedents have a positive influence on a firm’s AC and that these influences indirectly impact a biotechnology firm’s product innovations.

Originality/value
While a firm’s innovation is widely attributed to its AC, this study’s concept of competitive antecedents shows that a firm’s competitive advantage lies upstream from its AC.
Enhancing delivery: algorithms supporting performance management in the logistics sector
Authors: Al-Htaybat Khaldoon , von Alberti-Alhtaybat Larissa 
Published: December 2021

Purpose
The purpose of this study is to contribute an actor-network-theory (ANT) perspective of how algorithms are used and whether this reflects positively on organisational practices and related perceptions of organisation performance, by both customers and employees. Furthermore, the organisation’s view of adopting algorithms to manage their performance is explored.

Design/methodology/approach
The current study is a study set in this virtual space, as it seeks to use data available online from different stakeholders of the case organisation. Online “virtual space” studies have become more common over the past few years. Primary and secondary data are shared online, for instance on relevant rating websites for customers (such as TrustPilot) and employees (such as Indeed), which serve as a reflection of the organisational performance and the communication of their values. This type of study has become more prevalent, either as a study undertaken online fully (Hine, 2007) or partially (for instance Baxter et al., 2019), which provides a different perspective to traditionally carried out face-to-face interactions.

Findings
The current study has contributed insights from a global case organisation in the logistics sector originating in the Middle East (ME). The case organisation clearly indicates that its algorithm, in line with particular presentations and discussions on online platforms, is focussed on analysing limited factors, which are prediction of accurate delivery timeslot, preferred and precise location for delivery and speed of delivery overall. This reflects an inherent bias of the delivery industry, which the case organisation operates in, and may focus attention on delivering on those objectives, with a detrimental effect on the organisation’s broader organisational mindset. This refers to long-term values and sustainability-related objectives.

Originality/value
Findings will reflect on whether algorithms can be used to align a multi-national organisation to achieve its desired performance and related desirable results. This will be one of the main contributions of the current study, which engages with a multi-national organisation in the logistics sector that is based in the ME region.
Towards green product consumption: Effect of green marketing stimuli and perceived environmental knowledge in Indian consumer market
Authors: Jaiswal Deepak , Singh Bhagwan , Kant Rishi , Biswas Abhijeet 
Published: December 2021

Purpose
Consumers are becoming increasingly concerned about ecological degradation and are getting conscious of the potential advantages that environmental sustainability can offer, which is also driving them towards the consumption of green products. In view of this, the purpose of this study is to operationalize and test the conceptual model of green purchasing behaviour by incorporating consumers’ perception towards green marketing stimuli including eco-label, eco-brand and environmental advertisements with perceived environmental knowledge in an emerging sustainable market.

Design/methodology/approach
The proposed model is based on an integrative and cognitive approach to consumers’ environmental beliefs-behaviour relationship. The 549 valid responses were received from selected metropolitan regions of India and analysed by direct path coefficients along with a bootstrapping method for testing indirect effects.

Findings
The results revealed that perception of eco-label and environmental advertisements had a positive influence on green purchasing behaviour, however, the direct relationships of eco-brand and environmental knowledge were not supported in the model. While environmental advertisements and environmental knowledge posed an indirect influence on green purchasing to some extent.

Research limitations/implications
The generalizability of the findings needs to augment an extensive approach of a cross-sectional survey. Theoretical, managerial and policy implications were recommended to promote green products towards sustainable consumption.

Originality/value
The operationalization of green purchasing behaviour using marketing stimuli has remained scant in the Indian setting. The insights gained from this study contributes to the knowledge domain of green consumer psychology in the backdrop of an emerging market.
CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR‐433‐3p in non‐small cell lung cancer
Authors: Yu Jia , Zhang Haining , Zhao Chunsheng , Li Guanghui , Zhang Yingying , Sun Yang 
Published: December 2021

AbstractBackgroundCircular RNAs (circRNAs) participate in the genesis and progression of tumors, including non‐small cell lung cancer (NSCLC). At present, the role and regulatory mechanisms of circRNAs in NSCLC have not been fully elucidated. The aim of this study was to explore the role and regulatory mechanism of circRNA hsa_circ_0008037 (circ_0008037) in NSCLC.MethodsExpression of circ_0008037 in NSCLC tissues and cells was detected by quantitative real‐time polymerase chain reaction (RT‐qPCR). Loss‐of‐function experiments were performed to analyze the influence of circ_0008037 knockdown on proliferation, migration, invasion, and the Warburg effect of NSCLC cells. Western blotting was utilized for protein analysis. The regulatory mechanism of circ_0008037 was surveyed by bioinformatics analysis, RNA pulldown assay, and dual‐luciferase reporter assay. Xenograft assay was used to validate the oncogenicity of circ_0008037 in NSCLC in vivo.ResultsCirc_0008037 was upregulated in NSCLC tissues and cells. Circ_0008037 downregulation reduced tumor growth in vivo and repressed proliferation, migration, invasion, and decreased the Warburg effect of NSCLC cells in vitro. Mechanically, circ_0008037 regulated nuclear ubiquitous casein kinase and cyclin‐dependent kinase substrate 1 (NUCKS1) expression via sponging miR‐433‐3p. Furthermore, MiR‐433‐3p inhibitor reversed the inhibiting influence of circ_0008037 silencing on proliferation, migration, invasion, and the Warburg effect of NSCLC cells. Also, NUCKS1 elevation overturned the repressive influence of miR‐433‐3p mimic on proliferation, migration, invasion, and the Warburg effect of NSCLC cells.ConclusionCirc_0008037 accelerated tumor growth and elevated the Warburg effect via regulating NUCKS1 expression by adsorbing miR‐433‐3p, providing an underlying target for NSCLC treatment.
Videolaryngoscopy vs. direct Macintosh laryngoscopy in tracheal intubation in adults: a ranking systematic review and network meta‐analysis
Authors: de Carvalho C. C. , da Silva D. M. , Lemos V. M. , dos Santos T. G. B. , Agra I. C. , Pinto G. M. , Ramos I. B. , Costa Y. S. C. , Santos Neto J. M. 
Published: December 2021

SummaryVideolaryngoscopes are thought to improve glottic view and facilitate tracheal intubation compared with the Macintosh direct laryngoscope. However, we currently do not know which one would be the best choice in most patients undergoing anaesthesia. We designed this systematic review with network meta‐analyses to rank the different videolaryngoscopes and the Macintosh direct laryngoscope. We conducted searches in PubMed and a further five databases on 11 January 2021. We included randomised clinical trials with patients aged ≥16 years, comparing different videolaryngoscopes, or videolaryngoscopes with the Macintosh direct laryngoscope for the outcomes: failed intubation; failed first intubation attempt; failed intubation within two attempts; difficult intubation; percentage of glottic opening seen; difficult laryngoscopy; and time needed for intubation. We assessed the quality of evidence according to GRADE recommendations and included 179 studies in the meta‐analyses. The C‐MAC and C‐MAC D‐Blade were top ranked for avoiding failed intubation, but we did not find statistically significant differences between any two distinct videolaryngoscopes for this outcome. Further, the C‐MAC D‐Blade performed significantly better than the C‐MAC Macintosh blade for difficult laryngoscopy. We found statistically significant differences between the laryngoscopes for time to intubation, but these differences were not considered clinically relevant. The evidence was judged as of low or very low quality overall. In conclusion, different videolaryngoscopes have differential intubation performance and some may be currently preferred among the available devices. Furthermore, videolaryngoscopes and the Macintosh direct laryngoscope may be considered clinically equivalent for the time taken for tracheal intubation. However, despite the rankings from our analyses, the current available evidence is not sufficient to ensure significant superiority of one device or a small set of them over the others for our intubation‐related outcomes.
Oxcarbazepine was associated with risks of newly developed hypothyroxinaemia and impaired central set point of thyroid homeostasis in schizophrenia patients
Authors: Zhai Desheng , Chen Jinni , Guo Baoqiang , Retnakaran Ravi , Gao Songyin , Zhang Xiangyang , Hao Wei , Zhang Ruiling , Zhao Ying , Wen Shi Wu 
Published: December 2021

AimsHypothyroxinaemia might be easily ignored, because attention is typically paid to individuals with elevated thyroid stimulating hormone (TSH). In this study, we aimed to evaluate the association of oxcarbazepine use as adjuvant for treatment of schizophrenia with hypothyroxinaemia and central set point of thyroid homeostasis.MethodsThis retrospective cohort study was conducted in the Second Affiliated Hospital of Xinxiang Medical University. Inpatients with a diagnosis of schizophrenia admitted between January 2016 and October 2019 with normal thyroid function at admission were included. Oxcarbazepine use was the exposure measure. Newly developed hypothyroxinaemia was the primary outcome measure and parameters of thyroid homeostasis central set point as measured by TSH index and thyroid feedback quantile‐based index (TFQI) were the secondary outcome measures.ResultsIn total, 1207 eligible patients were included. The occurrence of hypothyroxinaemia in patients who received oxcarbazepine was higher (35/107, 32.7%) than in those patients who did not (152/1099, 13.8%), with adjusted relative risk of 2.24 and 95% confidence interval of 1.57 and 3.17. Oxcarbazepine use was associated with greater reduction in TSH index (adjusted β −0.33 and 95% confidence interval −0.48, −0.19) and TFQI (adjusted β −0.24 and 95% confidence interval −0.31, −0.16).ConclusionOxcarbazepine use was independently associated with increased risk of developing hypothyroxinaemia, and greater reduction in TSH index and TFQI, suggesting that impaired central set point of thyroid homeostasis might be involved in the mechanism of oxcarbazepine‐induced hypothyroxinaemia.
The prevalence of health problems and their association with physical activity in caregivers of children with disabilities: 2018 National Health Interview Survey
Authors: Ghim Seungbeen , Ku Byungmo 
Published: December 2021

AbstractBackgroundCaregivers of children with disabilities often experience poor health. One way for caregivers to promote their own health may be to participate in physical activity (PA).AimsThe purpose of this study was to examine the association between PA and psychological and physical health problems in caregivers of children with disabilities.MethodsThe 2018 National Health Interview Survey (NHIS) data were used, and 890 household representatives were identified as caregivers of children with disabilities. Based on the national PA guidelines, caregivers were classified into three groups: inactive (IA), aerobically active (AA), and aerobically and muscularly active (AMA).ResultsMultivariable logistic regression indicated that the AMA group had a lower likelihood of reporting depression compared to the IA group (OR: 0.73 [95% confidence interval: 0.54, 0.98]). The AMA group also had a lower likelihood of reporting back pain and obesity compared to the IA group (OR:0.69 [95% confidence interval: 0.56, 0.84] and OR:0.63 [95% confidence interval: 0.52, 0.76], respectively).ConclusionsThe results of the current study suggest that caregivers of children with disabilities may benefit from PA, especially from the combination of aerobic and muscle‐strengthening PA.
Visual habilitation in young children with visual impairment
Authors: Sahli Esra , Bingol Kiziltunc Pinar , Idil Aysun 
Published: December 2021

AbstractPurposeTo evaluate the effectiveness of the visual habilitation programme in improving the visual functions of visually impaired children under 3 years old.MethodsCase records of children with visual impairment (VI) who had at least 1 follow‐up visit were reviewed. Children's visual functions were scored between 0 and 15 based on mainly fixation and following skills. Differences in patients' visual function score (VFS) between the time of the presentation and the last follow‐up visit were recorded.ResultsOne hundred thirty children with VI (63 male and 67 female) were identified. The mean age at the presentation was 13.94 ± 9.23 months, and the mean follow‐up was 12.79 ± 9.4 months. Forty of the patients had ocular, 70 of them had cerebral, and 20 of them had combined VI. Correlations were found between the age of the patients at the presentation and the initial VFS; and gestational age and the initial VFS (p ˂ 0.001, r = 0.332; p ˂ 0.05, r = 0.262, respectively). Vision improvement was noted in ocular, cerebral and combined VI groups. No significant difference among the groups was found (p = 0.430). There was a significant difference between the change in the VFSs of those who attended the special education and rehabilitation centre regularly for 2 h a week and had regular visual stimulation for 8–10 sessions every day at home and those who did not go to the centre and did not receive any visual stimulation by their parents at home (p ˂ 0.001).ConclusionsThe visual functions of visually impaired children can be improved by habilitation, which includes visual stimulation programmes.
Segmental undergrowth is associated with pathogenic variants in vascular malformation genes: A retrospective case‐series study
Authors: Martinez‐Glez Victor , Rodriguez‐Laguna Lara , Viana‐Huete Vanesa , García Torrijos Carolina , Hurtado Begoña , Lapunzina Pablo , Triana Paloma , López‐Gutiérrez Juan Carlos 
Published: December 2021

AbstractSegmental overgrowth has been widely described in patients with congenital vascular anomalies. However, segmental undergrowth has been poorly characterized, and no large series of patients have been published. We present the clinical and molecular characteristics a cohort of 37 patients with vascular malformations and segmental undergrowth. True undergrowth was only considered when the musculoskeletal system was involved to avoid confusion with other causes of segmental reduction, as in lipodystrophy or the long‐term osteopenia seen in patients with Servelle–Martorell syndrome. Deep high‐throughput sequencing was performed in tissue samples from 20 patients using a custom panel. We identified three groups: undergrowth associated with (1) venous, (2) capillary‐venous, and (3) lymphatic‐capillary‐venous malformations. Congenital or early childhood onset undergrowth can occur with or without associated overgrowth. Different likely pathogenic or pathogenic variants were detected in 13 of 20 (65%) tissue samples in the PIK3CA, TEK, GNAQ, or GNA11 genes. In conclusion, the eponymous Servelle–Martorell syndrome should not be used as a synonym for undergrowth. Segmental undergrowth should be considered a characteristic associated with vascular malformations. Patients with PIK3CA variants show all different combinations of overgrowth and undergrowth. Thus, the term PROS (PIK3CA‐related overgrowth spectrum) does not cover the entire spectrum.
Can a large‐landscapeconservation vision contribute to achieving biodiversity targets?
Authors: Hebblewhite Mark , Hilty Jodi A. , Williams Sara , Locke Harvey , Chester Charles , Johns David , Kehm Gregory , Francis Wendy L. 
Published: December 2021

AbstractFounded in 1993, the Yellowstone to Yukon (Y2Y) vision was one of the earliest large‐landscape conservation visions. Despite growing recognition of large‐landscape conservation strategies, there have been few tests to date of conservation gains achieved through such approaches. We tested for conservation gains in the Y2Y region of North America following initiation of the Y2Y conservation vision in 1993 using a counterfactual spatiotemporal comparison and tracking change in five different conservation metrics. First, we enumerated the area of land within Y2Y in designated protected areas. We then compared the rate of change of protected area growth before‐ and after‐initiation of Y2Y in 1993 and to two adjacent counterfactual regions. Protected areas in the Y2Y grew by 7.8%, increasing by 107,289 km2, exceeding the Aichi target of 17% of the area under protection by 2018. More importantly, the rate of protected area growth increased 90% following initiation of the Y2Y large‐landscape conservation vision in 1993, whereas protected area growth declined in adjacent regions, or remained constant throughout North America. Sustained growth in protected areas and private land conservation was complemented by expansion of endangered grizzly bears in the U.S. portion of Y2Y, the greatest global expansion from zero to at least 117 wildlife road‐crossing structures and growing mainstreaming coverage of the Y2Y vision. Our counterfactual comparison provides valuable evidence that large‐landscape conservation strategies such as Y2Y can enhance protected area growth and other conservation metrics. We conclude that large‐landscape conservation strategies may be a useful model for achieving global large‐landscape conservation and biodiversity conservation targets.
“Indian” strains of Trichophyton mentagrophytes with reduced itraconazole susceptibility in Germany
Authors: Brasch Jochen , Gräser Yvonne , Beck‐Jendroscheck Vera , Voss Karen , Torz Kaspar , Walther Grit , Schwarz Thomas 
Published: December 2021

SummaryWe use published reports and three of our own tinea cases as an opportunity to report on “Indian” strains of Trichophyton (T.) mentagrophytes with ITS genotype VIII and reduced susceptibility to itraconazole due to the mutation c.1342G>A in the SQLE gene in Germany. In vitro measurements of resistance revealed normal susceptibility to terbinafine, but markedly reduced susceptibility to itraconazole – although no valid breakpoints are currently defined and minimum inhibitory concentrations (MICs) depend on the methods used. Problems related to the determination and interpretation of MICs are outlined. Our cases show that azole‐resistant “Indian” strains of T. mentagrophytes with ITS genotype VIII occurred in Germany as early as 2011, which is earlier than was previously assumed. This variant of the pathogen cannot be phenotypically distinguished from customary strains of T. mentagrophytes; its identification is based on genetics. The taxonomic classification is still under debate. This variant is anthropophilic and causes only mildly inflammatory tinea lesions with many fungal elements. Its further dissemination must therefore be expected. Prerequisites for rapid and valid antimycotic testing against dermatophytes need to be developed.
Identifying pathways to early‐onset metabolic dysfunction, insulin resistance and inflammation in young adult inpatients with emerging affective and major mood disorders
Authors: Tickell Ashleigh M. , Rohleder Cathrin , Ho Nicholas , McHugh Catherine , Jones Graham , Song Yun Ju Christine , Hickie Ian B. , Scott Elizabeth M. 
Published: December 2021

AbstractAimYoung people with common mood disorders face the prospect of shortened life expectancy largely due to premature cardiovascular disease. Metabolic dysfunction is a risk factor for premature cardiovascular disease. There is an ongoing debate whether metabolic dysfunction can be simply explained by weight gain secondary to psychotropic medications or whether shared genetic vulnerability, intrinsic immune‐metabolic disturbances or other system perturbations (e.g. dysregulated sympathetic nervous system, circadian dysfunction) are more relevant determinants of premature cardiovascular disease. Thus, we aimed to investigate underlying drivers of metabolic dysfunction and premature cardiovascular disease in young people in the early phases of common mood disorders.MethodsWe evaluated the relationships between insulin resistance (assessed by HOMA2‐IR) and body mass index (BMI), sex, diagnosis, medication, inflammatory markers and hormonal factors in 327 inpatients with emerging affective and major mood disorders admitted to the Young Adult Mental Health Unit, St Vincent's Private Hospital, Sydney.ResultsWhile HOMA2‐IR scores were positively associated with BMI (rs = 0.465, p < .001), they were also higher in those prescribed mood stabilizers (p = .044) but were not associated with specific diagnoses, other medication types or the number of prescribed medications. Further, high‐sensitivity C‐reactive protein levels (but not thyroid‐stimulating hormone and ferritin levels) were positively associated with HOMA2‐IR (rs = 0. 272, p < .001) and BMI (rs = . 409, p < .001).ConclusionsIn addition to BMI, other non‐specific markers of inflammation are associated with early metabolic dysfunction in young people with emerging affective and major mood disorders.