bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Profile and Outcome of Acute Kidney Injury: A Prospective Cross-sectional Study at a Tertiary Hospital in Addis Ababa, Ethiopia
Authors: Kefyalew Merahi , Azazh Aklilu , Siraw Bekure Bewket , Teklu Amanuel , Seid Abdulkerim , Admasu Tesfaye Nigussie 
Published: June 2021

Abstract
BackgroundAcute kidney injury (AKI) is a major health problem, causing morbidity in 13 million people annually, among which, 85% occur in developing countries. It is, therefore, one of the important issues in Africa where there is resource limitation at large, and appreciation of its pattern can help understand its causes, complications, and outcome better which are determinants for its early prevention and management. The objective of the study was to evaluate Patterns and outcomes of AKI patients who are admitted to the Tikur Anbessa specialized hospital (TASH) Adult Emergency Unit, Addis Ababa, Ethiopia. MethodsA prospective Cross-sectional study was done from August 1, 2018, to May 1, 2019. . A total of 144 cases of AKI were included in the study. Binary logistic regression was done for the identification of mortality predictors. Patients’ laboratory results on admission and discharge were compared by paired samples T-test. Survival time was estimated by Kapan- Meier and Log Rank Test with a 95% CI. ResultsThe mean age of presentation at a younger age of 46.16 ± 16.6, the most common causes of AKI were Sepsis (43.2%), volume depletion (25%), cardiorenal syndrome (16%), and obstructive uropathy (16%). Uremic encephalopathy, sepsis, and hyperkalemia were factors that were identified as mortality predictors in overall AKI patients.ConclusionAKI patients with sepsis were found to have lower hospital survival than those without sepsis. From the laboratory findings, there was a significant difference between creatinine values on admission and discharge.
Stabilizing Nanolasers via Polarization Lifetime Tuning
Authors: Lüdge Kathy , Meinecke Stefan , Roos Aycke 
Published: June 2021

Abstract
We investigate the emission dynamics of mutually coupled nanolasers and predict ways to optimize their stability i.e. maximize their locking range. We find that tuning the cavity lifetime to the same order of magnitude as the dephasing time of the microscopic polarization yields optimal operation conditions which allow for wider tuning ranges than usually observed in conventional semiconductor lasers. The lasers are modeled by a Maxwell-Bloch type class-C laser model. For our analysis we analytically determine the steady state solutions, analyze the symmetries of the system and numerically characterize the emission dynamics via the underlying bifurcation structure. The polarization lifetime is found to be a crucial parameter which impacts the observed dynamics in the parameter space spanned by frequency detuning, coupling strength and coupling phase.
WITHDRAWN: Mapping the FACT-G to EQ-5D-3L utility index in cancer: data from a cross-sectional study in in Guangxi, China
Authors: He ZhiKui , Liang WenJie , Xu WenJia , Huang WenXiu , Wang XiaoMin , Huang KaiYong , Yang Li 
Published: June 2021

Abstract
ObjectiveThis study aimed to develop a function for mapping the cancer-specific instrument (FACT–G) to a preference-based measure (EQ-5D-3L) utility index for HRQoL, in which the utility scores were generated using the Chinese value set.MethodThe data are based on a cross-sectional survey of 243 patients in China with different cancer types. Cancer patients who completed the EQ-5D-3L and the FACT-G questionnaire, and patient demographics and clinical characteristics were included in this study. Regression models were used to predict the EQ-5D-3L utility index values based on four subscale scores of the FACT-G using the ordinary least squares (OLS) model, generalized linear models (GLM), censored least absolute deviations (CLAD), Tobit model, and two-part model (TPM) regression approaches. The performance and predictive power of each model were also evaluated using r2 and adj- r2, mean absolute error (MAE) and root mean squared error (RMSE). Linear equating is a mapping technique that avoids regression to the mean.ResultsThe introduction of the square term and the interaction term improves the accuracy of the model. The social well-being subscale of the FACT-G was not associated with the EQ-5D-3L utility index, whereas, the physical, emotional, functional well-being, and FACT-G total scores were derived when mapping the FACT-G to the EQ-5D-3L utility index. For the FACT-G, the OLS model was the best at predicting mean EQ-5D-3L values among all the regression models and has 70% explanatory power for the observed EQ-5D-3L variation. Nevertheless, the OLS model overpredicted utilities for poorer health states and underestimated utilities for those with better health. The result of the OLS model, GLM, and CLAD models were similar to the MAE, MSE, and RMSE. The results showed that the mean prediction accuracy of the OLS models was higher than that of the other models, and the OLS model's linear equating predicted values were much closer to the observed values.ConclusionThe algorithm based on Chinese population development for mapping the FACT-G into the EQ-5D-3L utility index can be realized. We also recommend that OLS models be used to assess the economic evaluation of patients' health-related quality of life when the population is in moderate to good health for further cost-utility analysis in China.
Effect of antimicrobial therapy on progression free survival of patients with non-small-cell lung cancer receiving checkpoint-inhibitor- and chemotherapy
Authors: Uhlenbruch Mark , Krüger Stefan 
Published: June 2021

Abstract
BackgroundCheckpoint-inhibitor therapy (CPI) has significantly changed therapy in non-small cell lung cancer (NSCLC) in recent years. There is some data that the effect of CPI-therapy is influenced by the microbiome. Little is known about the influence and timing of antimicrobial therapy (AMT) on the microbiome mediated effect on CPI therapy.Patients and methodsWe retrospectively analysed 70 patients (age 68 ± 9,2y) with NSCLC stage IV. Patients were treated according to the guidelines with either CPI alone (pembrolizumab, nivolumab, atezolizumab) or chemotherapy (platin doublet or docetaxel / nintedanib or pemetrexed). We registered patients’ characteristics including presence and timing of AMT. Group 1 consisted of 27 patients with AMT in the month before CPI- or chemotherapy, group 2 were 30 patients with AMT during CPI- or chemotherapy, and group 3 were 43 patients without AMT.ResultsGroup 1–3 showed comparable patients characteristics. Using cox-regression analysis, we found that AMT in the month before CPI resulted in a decreased progression free survival (PFS) compared to patients with CPI and no AMT (14 ± 1.56 vs. 5 ± 0.99, p = 0.005, 95% CI: 0.13–0.67). In patients, who were treated with chemotherapy alone, there was no difference in PFS in those with or without AMT in the month before therapy (5+/- 0,99 vs. 6 ± 0.81 months, p = 0.3). Interestingly, AMT during chemotherapy or CPI therapy showed no effect on PFS.ConclusionsIn a real-life setting, we found that AMT reduces PFS when given in the month before CPI therapy. AMT before chemotherapy and during CPI and chemotherapy seems not to influence PFS. The best PFS was seen in patients without AMT before CPI therapy. This implies the need for an even more restrictive use of AMT in the context of patients with NSCLC stage IV disease.
Malignant Gastrointestinal Neuroectodermal Tumor in the Right Atrium: The First Case Report Presenting with an Extra-Gastrointestinal Mass
Authors: Li Zhiwen , Pu Xiaohong , Fu Yao , Li Lin , Xu Yuemei , Fan Xiangshan 
Published: June 2021

Abstract
Background: Malignant gastrointestinal neuroectodermal tumor is an extremely rare soft tissue sarcoma which was firstly described in 2003 but until recently it had been designated as a definite new entity. According to the previous literatures, Malignant gastrointestinal neuroectodermal tumor was almost exclusively occurred in gastrointestinal tract.Case presentation: A 62-year-old male showed a mass in right atrium and the occupying mass was founded on the right ventricular diaphragm and involved the right atrium along the coronary sinus during the operation. Microscopically, the tumor characterized by the solid sheet and pseudopapillary focally architectures, and was composed of small to medium cells with round or oval nuclei, variable amount of eosinophilic or clear, and frequent mitotic figures. Immunohistochemically, the neoplastic cells were positive for S100 and SOX-10 but negative for HMB-45, A103 and CD99. EWSR1-AFTF1 rearrangement was detected by fluorescence in situ hybridization and further confirmed involving fusion of EWSR1 exon 8 with ATF1 exon 4 by whole transcriptome sequence analysis.Conclusions: This is the first case report of extra-gastrointestinal Malignant gastrointestinal neuroectodermal tumor that occurring in the right atrium，which remind of the new prospect of the tumor location.
Measuring agency in children: the development and validation of the War Child Agency Assessment Scale - Palestinian version (WCAAS-Pal).
Authors: Veronese Guido , Pepe Alessandro , Cavazzoni Federica , Obaid Hania , Yaghi Shaher 
Published: June 2021

Abstract
In the present article, we aimed at construing a new quantitative measure of children's agency in Palestine. Within a socio-ecological and culturally and contextually informed perspective, the study introduces the development of a new instrument to investigate and evaluate children's agentic practices within their living contexts and their daily lives. First, we evaluated the model of measurement of WCAAS-Pal using a sequential exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Following the principles of testing a quantitative measure in the context of the dual-frame sampling method, the process of validating the quantitative measure was conducted on a group of 1,166 Palestinian children aged 9 to 14 years (m = 11.58, sd = 1.54). Second, a sample of 251 Palestinian children aged between 9 and 14 years (m = 11.82, sd = 1.53) was used to compute the reliability of the instrument along with both convergent and divergent validity using the Children Hope Scale and the Children Revised Impact of Event Scale-Arabic Version measures, respectively. The results of the EFA suggested a baseline seven-factor structure to be further assessed via CFA. A complex web of agency domains that might contribute to the child psychological functioning when forced to leave in conditions of ongoing threat and military violence emerged from the analysis.
Microcomputer software simulating problems in Rh immune globulin prophylaxis and hemolytic disease of the newborn
Authors: Hardman P.K. , Hardman J.T. , Brown P.J. , Borek D.A. , Beck M.L. 
Published: June 2021

Abstract
Our purpose was to develop educational software that would simulate laboratory investigation of problems in Rh immune globulin prophylaxis and hemolytic disease of the newborn. An interactive, blanching style program was developed using a 256K Personal Computer (International Business Machines, Boca Raton, FL). The software has been used in over 125 institutions for preprofessional and continuing professional education.
Immunohematology
1991;1:12–15.
Procedural errors in antibody identification
Authors: Strohm P.L. , Smith P.J. , Fraser J.M. , Smith J.W. , Rudmann S.V. , Svirbely J.R. , Miller T.E. , Blazina J.F. , Kennedy M.S. 
Published: June 2021

Abstract
In experimental studies of students and line technologists performing antibody identification procedures, both groups made errors. These errors included, at times, either failing to identify an antibody or misidentifying the specificity(ies). A prospective study was undertaken to identify errors made in a laboratory setting. Errors were classified as 1) failing to follow protocol (procedural error) or 2) arriving at the wrong answer (misidentification error). Over a 1-year period, 1,057 workups were reviewed. There were 41 (3.88%) procedural errors and no misidentification errors. In 25 workups (61% of errors), the selection of cells to rule out underlying alioantibody(ies) was in error. The remaining 16 involved various “slips” (minor mistakes or memory lapses) and clerical errors. Based on an analysis of the probable causes of these errors, potential solutions include 1) developing computer aids to detect “rule-out” errors or missing tests results; 2) providing timely, carefill review of workups before transfusion; and 3) designing better panel layout and cell selection.
Immunohematology
1991;1:20–22.
Indicators of clinically significant red cell antibodies produced by sensitized lymphocytes in liver transplant patients
Authors: Calhoun B. , Pothiawala M. , Musa G. , Baron B. 
Published: June 2021

Abstract
It has been documented that transplanted livers can carry sensitized lymphocytes that subsequently produce red cell antibodies. We evaluated immunohematological variables in liver donors and recipients for indicators that might be predictive of serological red blood cell (RBC) destruction mediated by the passenger lymphocytes. Organ donor sera with antibody scores greater than (>) 60 correlated with a positive direct antiglobulin test (DAT) and need for increased RBC transfusion in liver transplant recipients. We therefore propose an antibody screen on all potential liver donors and titration of unexpected alloantibodies; titration of ABO antibodies of liver donors who demonstrate minor ABO-incompatibilities with their recipients; and, when needed, transfusion of group O RBCs to recipients of livers from donors with minor ABO-incompatibility who have antibody scores > 60.
Immunobematology
1991;2:37–39.
Use of a modified acid/EDTA elution technique
Authors: Byrne P.C. 
Published: June 2021

Abstract
A modification of the acid/EDTA elution technique was recently developed at the International Blood Group Reference Laboratory, Bristol, UK. By altering the volumes of reagents used, maximization of elution of antibody could be achieved without loss of red cel] integrity.
Immunobematology
1991;2:46–47.
The incidence of WESa in 3,072 donors in the United States
Authors: Copeland T.R. , Smith J.H. , Wheeling R.M. , Rudolph M.G. 
Published: June 2021

Abstract
The rare red cell antigen, WESa, which is controlled by an autosomal dominant gene, was reported by Sistonen et al.1 to have an incidence in the Finnish population of 0.56 percent. A study was undertaken to determine the incidence of the WESa antigen within the United Stales. A total of 3,072 donor samples were obtained for testing from eight different geographical locations. It was determined that the incidence of the WESa antigen in the white donor population tested was 2 per 1,610 or 0.12 percent and in the black donor population tested, 7 per 1,460 or 0.48 percent. In the random population the incidence would be 0.29 percent.
Immunohematology
1991;7:76–77.
Human leukocyte antigens (HLA) class I (Bg) on red cells studied with monoclonal antibodies
Authors: Giles C.M. 
Published: June 2021

Abstract
Monoclonal antibodies, capable of detecting monomorphic epitopes on HLA class I polypeptides and beta-microglobulin (β2-M), have been used by a variety of techniques to ascertain the type of structure detected on red blood cells (RBCs). Hemagglutination with class I monoclonal antibodies confirmed the reported relationship between Bg blood groups and HLA. It also established that the expression of HLA on RBCs which do not have nuclei is not normally strong, but may be enhanced in patients, notably those with systemic lupus erythematosus (SLE). Estimates of the number of class I molecules on mature RBCs by a radioligand-binding assay have confirmed that all HLA-B7 (Bga) individuals have higher numbers but that SLE patients usually have the most (1240/RBC). Class I polypeptides were not elevated in the plasma of SLE patients and all RBCs lost molecules on aging in the circulation. These two facts suggest that HLA on RBCs is not acquired from plasma. When RBCs from SLE patients were immunoblotted with monoclonal antibodies, a complete 45 kDa intrinsic transmembrane heavy chain of HLA class I and a light chain of 11 kDa (β
2-M) were detected. Chloroquine treatment and acid elution of RBCs did not remove HLA class I but only β
2-M. As most antibodies recognize epitopes that depend on close association of class I with β
2-M, the lost reactivity of treated RBCs may be understood.
Two cases of autoantibodies that demonstrate mimicking specificity in the Duffy blood group system
Authors: Harris T. 
Published: June 2021

Abstract
Two transfused Caucasian patients presented with possible delayed transfusion reactions. Both patients demonstrated an anti-Fya (Fy1) plus anti-Fyb (Fy2) pattern of reactivity in their sera. The patients’ red blood cells (RBCs) were Fy:1,–2,3. Both had positive direct antiglobulin tests (DAT) with anti-IgG and -C3d. The serum antibodies reacted with the patients’ RBCs drawn when the DATs were negative Both patients’ serum samples showed reactivity with Fy:1,–2 (1 +), Fy:–1,2 (3+), Fy:1,2 (3+) RBCs at the antiglobulin phase (ACT) but were nonreactive with Fy: –1, –2 RBCs. The anti-bodies in both cases were nonreactive with papain- or ficin-treated RBCs -and reacted with Rhnull RBCs, which ruled out anti-Fy3 and anti-Fy5, respectively. These cases suggest mimicking autoantibody specificities in the Duffy system. One case may indicate that the degree of reactivity is dependent on the Duffy phenotype of the RBCs tested (Fy: –1,2 > Fy:1,2 > Fy: –1, – 2). An unusual characteristic seen in both of these cases was hemolysis in the EDTA cell samples but none in the clotted samples.
The P1H antigen and antibody
Authors: Moores P.P. 
Published: June 2021

Abstract
P1H, a newly discovered compound antigen associated with both the ABO and P systems, occurs in approximately 7 percent of Natal (South African) blacks. The compound antigen is evident only when the red cells have exceptionally strong expression of both P1 and H antigens, and it is apparently a dominant character. The antigen is thought to originate by steric rearrangement in the molecule, or to be the product of competition between P
1 and H gene transferases for the available paragloboside. The corresponding antibody, anti-P1H, has been made by both P2 and P2 people and is a weak cold agglutinin. It is not adsorbed by red cells carrying either strongly expressed P1 or H antigens, but is adsorbed by and eluted from P1H+ red cells sensitized by anti-P1H. The antibody is inhibited by P1 but not by H, Lewis, or Sda substances.
Immunohematology
1993;9:7.
En(a–) phenotype in a Japanese blood donor
Authors: Okubo Y. , Seno T. , Yamaguchi H. , Miyata Y. , Green C.A. , Daniels G.L. 
Published: June 2021

Abstract
The first Japanese En(a–) individual (T.N.) was found by screening red cells from 250,000 Japanese blood donors with monoclonal anti-Ena. His serum contained no atypical antibodies and his partial red cell phenotype was M–N–S+s–, although a trypsinresistant N antigen was detected. His red cells were En(a–) and Wr(b–), as determined by various human and mouse monoclonal antibodies. The absence of glycophorin A (GPA) and the presence of apparently normal glycophorin B (GPB) were demonstrated by immunoblotting with antibodies to the extracellular and cytoplasmic domain of GPA and to epitopes common to GPA and GPB. Sialic acid levels of T.N.’s intact red cells were substantially lower than those of control MN cells. Serologic tests suggested that both of T.N.’s parents were heterozygous for a recessive GPA deficiency gene.
Immunohematology
1993;9:105.
Red cell antigen stability in K3EDTA
Authors: Westhoff C.M. , Sipherd B.D. , Toalson L.D. 
Published: June 2021

Abstract
Commercial blood grouping reagents are not approved for testing EDTA anticoagulated blood specimens that are more than 48 hours old. Many studies on the stability of blood group antigens in other anticoagulants have been reported, but none are available for EDTA. This study was undertaken to assess whether current commercially available blood grouping reagents give acceptable reactions with red cell antigens when the cells are stored for extended periods in EDTA We defined acceptable reaction strength to be 2 + (score 8). As expected, the A, B, and D reactions were very stable with red cells stored for 60 days. All antigens except Lea exhibited 2+ (score 8) or greater reactions at day 14, and at day 21 only the Lea, Fyb, and e antigens were less than 2+. On day 60, twelve of twenty-one antigens tested still exhibited 2+ or greater reactions. This study shows that antigen reactivity for red cells collected and stored in EDTA is at least equal to that for clotted specimens. These red cells can be used for reliable antigen typing for at least 14 days, and even longer for most antigens.
Immunohematology
1993;9:109.
Failure to detect a prozoning anti-Fya in the serum of a chronically transfused patient
Authors: Sizemore J.C. , Sammons T.D. , Clanton J.N. 
Published: June 2021

Abstract
A 78-year-old white male presented to our facility with vascular occlusion. He was Group A, D-positive, with a negative indirect antiglobulin test (antibody screen). Records at our facility, 4 years prior to this admission, indicated a history of anti-Fya, and Fy(a−) units were provided. A referring hospital had transfused the patient for “chronic anemia” (1-3 units weekly for 2 years), and he had received eight units (untested for Fya) immediately prior to his transfer to our facility for acute hemorrhage. Only the presence of anti-IH in the serum was documented. To detect possible immune red cell destruction, the patient was monitored by our facility at 24-hour intervals with a direct antiglobulin test and antibody screen. On day 4, a 4+ anti-Fya was identified in the serum and the DAT was negative. Three days later anti-K was also identified. The serologic picture remained unchanged for 10 days, when the DAT became positive. Concurrently, a mixed-field Fya typing (on the patient’s chloroquinediphosphate-treated cells) was detected. Repeat Fya typing of all units transfused at our facility confirmed their Fy(a-) status. From the day of admission, eluates on every sample, using a low pH technique, showed anti-Fya specificity. Titration of the anti-Fya but not in neat serum. Although a prozoning phenomenon is uncommon, thi in the sample drawn on admission reacted from a dilution of 4 through 2,048 s case study suggests that a prozoning anti-Fya present in the patient’s serum may have been a contributing factor to his “chronic anemia.”
Intmunobenurtology
1992;8:44–46.
Case report: mixed-field agglutination in a patient with a weak D antigen presenting as a possible fetal-maternal hemorrhage
Authors: Unger P.J. , Rapini J. , DelMores F. , Howard C. , Znavor J. , Behzad O. , Rossi E.C. 
Published: June 2021

Abstract
A gravida 1, para 0, 17-year-old black female was found on pre-natal testing to he group O, Duu, the latter test showing many unagglutinated cells. Because of the mixed-field appearance, the patient was thought initially to have bad a fetal-maternal hemorrhage. Additional red cell typings were performed, but no other apparent mixed-field reactions were observed. The Kleihauer-Betke test and hemoglobin electrophoresis indicated that the mixed-field agglutination was not due to a fetal-maternal hemorrhage. Thus, the finding of a mixed-field D typing could he explained best by a weak D antigen.
Immunohematology
1992;8:77-78.