bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Clinical Psychopharmacology in Borderline Personality Disorder
Authors: Del Casale Antonio , Bonanni Luca , Bargagna Paride , Novelli Francesco , Fiaschè Federica , Paolini Marco , Forcina Francesca , Anibaldi Gaia , Cortese Francesca Natalia , Iannuccelli Alessia , Adriani Barbara , Brugnoli Roberto , Girardi Paolo , Paris Joel , Pompili Maurizio 
Published: June 2021

Background:
Patients with Borderline Personality Disorder (BPD) manifest affective and
behavioral symptoms causing personal distress, relationship difficulties, and reduced quality of life
with global functioning impairment, mainly when the disease takes an unfavorable course. A substantial
amount of healthcare costs is dedicated to addressing these issues. Many BPD patients receive
medications, mostly those who do not respond to psychological interventions.

Objective:
Our aim was to assess the efficacy of the most used strategies of pharmacological interventions
in BPD with a comprehensive overview of the field.

Methods:
We searched the PubMed database for papers focused on the most used psychotropic
drugs for BPD. We included randomized controlled trials and open studies in adult patients with
BPD, focusing on the efficacy and tolerability of single classes of drugs with respect to specific
clinical presentations that may occur during the course of BPD.

Results:
Specific second-generation antipsychotics (SGAs) or serotonergic antidepressants can be
effective for different core symptoms of BPD, mainly including mood symptoms, anxiety, and impulse
dyscontrol. Some atypical antipsychotics can also be effective for psychotic and dissociative
symptoms. Specific antiepileptics can be useful in some cases in treating different BPD symptoms,
mainly including mood instability, impulsiveness, and anger.

Conclusions:
No medication is currently approved for BPD, and clinicians should carefully assess
the benefits and risks of drug treatment. Further studies are needed to identify specific personalized
treatment strategies, also considering the clinical heterogeneity and possible comorbidities of BPD.
Recent Advancements and Patents on Buccal Drug Delivery Systems: A Comprehensive Review
Authors: Srivastava Nimisha , Aslam Sahifa 
Published: June 2021

:The major requirement for a dosage form to be successful is its ability to penetrate the site of application and the bioavailability of the drug released from the dosage form. The buccal drug delivery is an influential route to deliver the drug into the body. Here, in this context, various novel approaches that include lipoidal carriers like ethosomes, transferosomes, niosomes etc and electrospun nanofibers are discussed, with respect to buccal drug delivery. These carriers can be easily incorporated into buccal dosage forms like patches and gels that are responsible for increased permeation across the buccal epithelium. The in vivo methods of evaluation on animal models are conscribed here. The novel biocarriers of lipoidal and non-lipoidal nature can be utilized by loading the drug into them, which are helpful in preventing drug degradation and other drawbacks as compared to conventional formulations. The globally patented buccal formulations give us a wide context in literature about the patents filed and granted in the recent years. When it comes to patient compliance, age is an issue, which is also solved by the buccal route. The pediatric buccal formulations are researched for the customization to be delivered to children. Diseases like mouth ulcers, oral cancer, Parkinson’s disease, aphthous stomatitis etc. have been successfully treated through the buccal route, which infers that the buccal drug delivery system is an effective and emerging area for formulation and development in the field of pharmaceutics.
Formulation and Evaluation of Cassia tora Phytosomal Gel Using Central Composite Design
Authors: Corrie Leander , Gundaram Raghunandan , Kukatil Latha 
Published: June 2021

Background::
Cassia tora has been classified as an antifungal agent, but no
optimized formulation for improved drug penetration has been developed.

Objective::
The present work aimed to formulate Cassia tora extract (CTE) phytosomal
gel that could be used for its antifungal effects and improved therapeutic activity.

Materials and Methods:
The CTE phytosomes were formulated by varying the concentration
of lecithin (0.15-0.25% w/v) and speed of rotation (100-160 rpm). A 22 factorial
design was applied by taking the above two parameters as independent variables and vesicular
size and entrapment efficiency as dependent variables. The phytosomes were also
evaluated for polydispersity index, zeta potential and in vitro drug release. The optimized
phytosomes of CTE were further developed into a gel, the optimized gel was also
evaluated, and the stability studies were conducted.

Results and Discussion:
The optimized CTE phytosome showed a vesicular size of ~
124 nm and entrapment efficiency of 95%. The CTE phytosomes showed a drug release
of 58.79% in 24 hours following the Higuchi order of release. The CTE phytosomes
were formulated into a gel by using 1% Carbopol 934 and were evaluated for pH, viscosity
and homogeneity. The formulated gel showed better penetration than conventional
gel, and stability changes indicated no major changes to the CTE phytosomal gel.

Conclusion:
The optimized gel had better penetration and drug release than the conventional
gel. Its therapeutic activity, therefore, can be enhanced.
Phylogenetic tree analysis based on the 16S sequence alignment for Klebsiella spp. isolated from different sources
Authors: Ibrahim Israa AJ. , Kareem Tuqa A. , Azeez Yaseen M. , Falhi Hawraa K. 
Published: June 2021

16S ribosomal RNA (16S rRNA) gene sequences used to study bacterial phylogeny and taxonomy have been by far the most common housekeeping genetic marker utilized for identification and ancestor determination. This study aimed to investigate, for the first time, the relationship between Klebsiella spp. isolated from clinical and environmental samples in Iraq.
Fifty Klebsiella spp. isolates were isolated from clinical and environmental sources. Twenty-five isolates were collected from a fresh vegetable (Apium graveolens) and 25 from clinical samples (sputum, wound swab, urine). Enteric bacteria were isolated on selective and differential media and identified by an automatic identification system, vitek-2. The total DNA was extracted and PCR amplified for selected isolates. The 16S rRNA gene was amplified by using the universal primer 27F (5'- AGAGTTTGATCCTGGCTCAG- 3') and 1492R (5'- GGTTACCTTGTTACGACTT- 3â€™). The 16SrRNA gene sequence was analysed among some local isolates, and the results were compared with the standard data of similar registered strains in NCBI. The most common species of Klebsiella was Klebsiella pneumoniae pneumoniae (Kpp), followed by Klebsiella pneumoniae ozaenae (Kpo) and Klebsiella oxytoca (Ko). The results of the identification of species and sub species by using the biochemical test (vitek-2) were more precise than those obtained by the use of the universal primer.Phylogenetic tree strategies have clearly indicated a relatively close similarity amongst all analysed Klebsiella isolates and revealed the intra-species genetic distance between the individual isolates of the Klebsiella spp. In conclusion, our results revealed the main advantage of using universal primers for the identification of Klebsiella spp. and their root from nature.
“Hot Chicks on Board” – Gender, Meat, and Violence in Food Marketing in, and from, South Africa
Authors: Tsampiras Carla 
Published: June 2021

From local wholesale delivery trucks that transport the flesh of chickens, to sexist adverts by South African-owned fast-food chains with national and international reach, the gendered nature of the marketing and consumption of meat in South Africa is evident in multiple media. This article analyses vehicle livery and television and printed adverts devised to sell meat to consumers, and argues that the representations of bodies – those of womxn and the bodies of other species – as being available for consumption (visual or otherwise), is an expression of the gendered social processes associated with food “production” and consumption (visual and physical) and the patriarchal capitalocene. The representations and production of food are innately linked to multiple forms of violence, including the repetitive visual aggressions associated with the female form being constantly under scrutiny and available for consumption. In the visual representations of convenience foods, the food and the absent referents they rely on deploy stereotypes of heteromasculinities and (hyper)femininities and are used to reinforce hierarchies of gender, species, and economic systems (and the violence associated with them). These images and food items thus act as “ordinary” indexes of patriarchal, capitalocene power relations.
Intravenous versus inhalational anesthesia trial for outcome following intracranial aneurysm surgery: A prospective randomized controlled study
Authors: Bhagat Hemant , Sharma Tanavi , Mahajan Shalvi , Kumar Munish , Saharan Poonam , Bhardwaj Avanish , Sachdeva Naresh , Gandhi Komal , Jangra Kiran , Panda Nidhi Bidyut , Singla Navneet , Kishore Kamal , Singh Nidhi 
Published: June 2021

Background:
For maintenance of anesthesia for intracranial aneurysmal neck clipping, both intravenous and inhalational anesthetics are in vogue. We aimed to evaluate the superiority of one agent over the other for long-term neurological outcomes in these patients.

Methods:
This prospective assessor-blind randomized study was conducted in 106 patients of 18–65 years of age with World Federation of Neurosurgeons Grade I-II of subarachnoid hemorrhage. After written informed consent, the patients were randomized into – intravenous group (Propofol) and inhalational group (Desflurane). The primary outcome was to study neurological outcome using Glasgow outcome scale (GOS) at 3 months following discharge while secondary outcomes included intraoperative brain condition, intraoperative hemodynamics, duration of hospital stay, Modified Rankin Score (MRS) at discharge, MRS, and Barthel’s index at 3 months following discharge and estimation of perioperative biomarkers of brain injury.

Results:
The GOS at 3 months was 5 (5.00–5.00) in the propofol group and 5 (4.00–5.00) in the desflurane group (P = 0.24). Both the anesthetics were similar in terms of intraoperative hemodynamics, brain relaxation, duration of hospital stay, MRS at discharge and 3 months, and Barthel Index at 3 months (P > 0.05). The perioperative serum interleukin-6 and S100B were comparable among the groups (P > 0.05).

Conclusion:
The long-term neurological outcome of good grade aneurysm patients undergoing craniotomy and clipping remains comparable with the use of either propofol or desflurane. The effect of the two anesthetic agents on the various clinical parameters and the biomarkers of brain injury is also similar.
LEGAL ISSUES FOR ELECTRONIC DOCUMENTS WORKFLOW REGULATION
Authors: K. Kussainova Ainur , O. Kussainov Duman , S. Zhumagulov Bolat , K. Simtikov Zhomart , O. Zhangutin Baurzhan 
Published: June 2021

Purpose ”“ The main purpose of the paper is to analyze the problems of legal regulation of relations in the field of electronic document management.
Methodology/approach/design ”“ The paper employs methods of comparative law and analytical, which determine the possibility of integrating international standards for the regulation of electronic document flow.
Findings ”“ Electronic document flow is becoming an integral part of the most diverse areas of economic activity of any enterprise. The document flow contains elements of the general law of regulation and reaffirms the necessity of following specific instructions. Its electronic form allows the information interchange between subjects of economical and legal activity. This defines the possibility of the formation of a separate branch of legal regulation in the document flow. The possibility of the structuring and correlation of an informational and another branch of the law for the aim of complex usage of an electronic document flow is viewed as a separate aspect.
Practical implications ”“ Material of the article may be useful in matters of regulation of the legislative system of document management.
Originality/value ”“ The novelty of the study is that the article examined in detail the mechanism of electronic document management in different countries.
THEORETICAL AND METHODOLOGICAL FOUNDATIONS OF MODERN BANKING SUPERVISION
Authors: Shvets N. R. 
Published: June 2021

The necessity of new, modern, adapted to the requirements of the economic realities theoretical and methodological bases of banking supervision implementation formation in Ukraine is justified by the author. The global and national trends in the functioning of the banking supervision system are investigated in the article. Some flaws and shortcomings in the action of international and national supervisory authorities are selected. The constructive proposals of the theoretical and methodological foundations of modern banking supervision in Ukraine are proposed.Key words: bank, banking, banking supervision, the National Bank of Ukraine, the Basel Committee of Banking Supervision.
Evaluación de desempeño y el desarrollo de actitudes y competencias del personal
Authors: Mora Aristega Julio Ernesto , Montiel Díaz Práxedes América , Huilcapi Masacón Magdalena Rosario , Escobar Mayorga Diana Carolina 
Published: June 2021

La evaluación de desempeño es un mecanismo muy importante que se realiza en todo tipo de empresas, cuyos resultados son indicadores sobre la situación del personal y de los niveles de eficiencia alcanzados, esta investigación se realiza para determinar el uso que se le da a los resultados y establecer la importancia de un proceso de evaluación transparente y confiable para los directivos y el personal; para el desarrollo de la investigación se aplica una encuesta al personal involucrado tomando como base treinta y cinco personas del área administrativa de las Unidades Médicas del Instituto Ecuatoriano de Seguridad Social, Provincia de Los Ríos, de los cuales se obtuvo información relevante que permitió concluir respecto a que Los resultados de la evaluación de desempeño son la fuente primaria para tomar acciones correctivas en los procesos administrativos de las entidades.
Role-play para la atención farmacéutica en la pandemia COVID-19 como método de enseñanza para los estudiantes de Farmacia y Bioquímica
Authors: Vilchez Cáceda Héctor Alexander , Cervantes Ganoza Luis Adolfo , Rojas Berastein Ketty , Inocente Camones Miguel Angel 
Published: June 2021

Introducción: La pandemia por COVID-19 ha obligado la educación universitaria bajo una modalidad de aprendizaje a distancia en línea. La Atención Farmacéutica en la pandemia COVID-19, implica la intervención del Químico Farmacéutico para el apoyo al usuario en la entrega del medicamento y acompañamiento de la terapéutica desde la Oficina Farmacéutica; por ello el juego de roles es parte de una serie de estrategias de tipo participativa a eventos concretos y es positivo para fomentar competencias de trabajo cooperativo en estudiantes.
Método: El diseño es experimental al azar controlado, dos equipos como control y un equipo experimental. Los datos cuantitativos (calificación) y cualitativos (sondeo de satisfacción) estuvieron agrupados para determinar el efecto del role-play en los estudiantes.
Resultados: La calificación fue mayor en el equipo experimental comparado con los controles. El estudio cualitativo del equipo experimental señala a los estudiantes como satisfechos en el proceso realizado, el rol del docente, el desempeño en equipo y el periodo fijado.
Conclusiones: El uso de role-play demostró ser una herramienta importante para la enseñanza de atención farmacéutica en plataformas virtuales durante la pandemia de COVID-19 favoreciendo el feed-back de los conocimientos y facilita la valoración de la respuesta de los estudiantes y sus reacciones en el entorno de eventos de acuerdo con la realidad social.
El consumo cultural como medio de diferenciación y diversidad en los procesos de formación docente
Authors: Muñoz Mancilla Martín 
Published: June 2021

El propósito de este trabajo es conocer la importancia que tiene el consumo cultural en los procesos de formación docente para dar cuenta que en la era neoliberal se evalúa de igual manera a instituciones y alumnos diferentes. Se analizan los conceptos de consumo cultural, posteriormente el contexto social, cultural y económico donde se ubican tres Escuelas Normales en México a las que se les evalúa de igual manera pese a que sean totalmente diferentes. En esa dinámica se favorece a quienes poseen mejores condiciones estructurales y una vida urbana.
PERLINDUNGAN HUKUM PASAR TRADISIONAL TERHADAP PERKEMBANGAN TOKO MODERN DI KABUPATEN BOGOR
Authors: Suryani Danu , Roestamy Martin 
Published: June 2021

This study aims to determine the direction, obstacles and the best models in the legal protection of Traditional Markets in Bogor. The local government has implemented several programs such as modernization and markets building systems of Modern Stores also published Regulation No. 11 Year 2012 about structuring and development of Traditional Markets. The program wasn’t appropriate in the view of modernization market bulding as well as local regulations put Traditional Market in hard position as well as the rent price isn’t affordable for small traders and it can erode the local wisdom, it seems like suspending the failure of traditional market. The study concluded that the legal protection for both traditional market today is a model of traditional market-based that not only develops Traditional Market physically, but also can protect the local wisdom, values or cultural norms in Traditional Markets and lead Traditional Market as a place for the Farmers and local SMEs to display agricultural products, so that the traditional market can be a venue for sightseeing and socializing as well as supporting the development of Farmers and local SMEs and do not intersect with Modern Store.
IMPLEMENTASI HUKUM PERUMAHAN SEBAGAI USAHA PERCEPATAN PENGADAAN RUMAH BAGI MASYARAKAT YANG BERPENGHASILAN RENDAH (MBR)
Authors: Sihotang Sudiman 
Published: June 2021

In the preamble of the two basic considerations Act No. 1 of 2011 on Housing and Region Settlements (Act PKP "That the state is responsible for protecting all Indonesian citizens through the implementation of housing and residential areas so that people can live and occupy decent housing and affordable in the housing healthy, safe, harmonious, and sustainable in all regions of Indonesia. "Although the regulations with regard to the procurement of low-income housing has been a lot made, but the fact still occur backlog (number gap between the need and availability of home) as contained in the Strategic Plan of the Ministry of Public Works and public housing in 2015-2019 which states that until 2014, the remaining backlog of as many as 11.4 million homes. this reflects the need to optimize housing law to accelerate the supply of homes for low income people (MBR). by using the methodology and theories from the academic side, the present study was designed to find out why the housing law has not been effective in an effort to facilitate access to home ownership for MBR and also to know how to optimize housing law to facilitate access to home ownership for MBR. Therefore the targeted outcomes of this study apart from a Dissertation (draft dissertation) approved supervisor, scientific publications in journals of international repute and enrichment of teaching materials on the subject property law in Indonesia that is taught at the Faculty of the University of Djuanda Bogor. This study also we target to become an academic paper for the improvement of relevant legislation Property in Indonesia
IDENTIFICATION OF RACIAL AND ETHNIC DISCRIMINATION ACCORDING TO LAW NUMBER 40 OF 2008 AND DISCRIMINATION WOMEN ACCORDING TO LAW NO. 7 OF 1984 IN CIVIL CODE
Authors: Hasyim Dardiri 
Published: June 2021

This research attempts to find forms of discrimination in the Act No. 40 of 2008, Act No. 13 of 2003, as well as Act No. 7 of 1984, and compare with Civil Code. Research using the method of librarianship. The results showed there are 19 articles in the Civil Code which is discriminatory. In the meantime there are 6 forms of discrimination in the Act No. 40 of 2008; and 17 form in Act No. 7 of 1984.
APPOINTMENTS OFARBITERS IN INDONESIAN NATIONAL BOARD OF ARBITRATION IN CIVIL CASEBASED ON LAW OF THE REPUBLIC OF INDONESIA NUMBER 30 OF 1999 CONCERNING ARBITRATION AND ALTERNATIVE DISPUTE RESOLUTION
Authors: Nurjanah Ayi 
Published: June 2021

This study aims to find out application and effectiveness of Law no. 30 of 1999 on the Indonesian National Board of Arbitration (BANI) of South Jakarta, especially regarding the mechanism of its implementation of arbitral tribunal elections and their impact on settlement of arbitration dispute on the institution, and to know the obstacles that hinder the success of arbitration. This research is normative juridicial with the approach of legislation and analytical approach. Data collection techniques are field studies through interviews with related parties. Research data consist of primary and secondary data. Primary data were obtained by direct interviews using structured interview guidelines. Meanwhile,, the secondary data obtained by reviewing documents and literature related to the object of research. Then such data is obtained and is analyzed qualitatively by explaining the problems as discussed in the thesis. From the results of the study, what can be concludedthat: (1) measures the election and appointment of arbitrators is proven effective due to its large impact on the settlement of the dispute so that it can be done more quickly than the general courts. (2) Based on the authority of the arbitrators, an effortto implement Law No. 30 of 1999 has been well implemented as stipulated in the regulation, but there are still factors that hinder the success of arbitration to BANI which come from the parties, arbitrator's inability, high cost of arbitration and public knowledge about unpopular arbitration institution.
Anticancer Potency of Copper(I) Complexes Against a Range Cancer Cell Lines: A Review
Authors: Singh Narendra Kumar , Yadav Paras Nath 
Published: June 2021

The copper(I) complexes of N,N-diimine, N,O- and/or N, S-bidentate systems perform significant dose-dependent anticancer activity toward various cell lines viz. MCF-7, LNCap, PSN-1, A431, BxPC3, H157, A2780, HeLa, MDA-MB231, MGC-803 etc. The copper(I) complexes can cross the cellular plasmalemma that results in the accumulation of copper ion in the cancer cells, exhibit significant anticancer effect and overcome the multidrug resistance because these can slightly induce the DNA cleavage as a result of limited generation of reactive oxygen species (ROS). Copper(I) complexes exhibit significantly higher broad-spectrum antiproliferation and cell apoptosis via mitochondrial pathway than that of their corresponding Cu(II), Co(II), Pd(II), and Ni(II) complexes. The copper(I) complexes inhibit the cancer cells not only via ROS generation but also via DNA interactions possibly by attacking the sugar-phosphate backbone of DNA due to their oxidative and partial dissociation behavior. Copper(II/I) complexes are also able to cleave DNA by hydrolytic pathway and induce caspase-dependent-mitochondrial-mediated cell apoptosis by ROS production or blocking the progression of cell cycles. In many cases, the modification in organic moiety and the placement of electronegative substituent near the metallic center of complexes have been found to enhance their anticancer potency in a significant manner. Thus copper(I) complexes may be used as the better anticancer drugs with multiple modes of action compared to the copper(II) complexes due to having oxidative behavior and generation of empty site on copper(I) ion during partial dissociation.