dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project
Authors: Ogishima Soichi , Nagaie Satoshi , Mizuno Satoshi , Ishiwata Ryosuke , Iida Keita , Shimokawa Kazuro , Takai-Igarashi Takako , Nakamura Naoki , Nagase Sachiko , Nakamura Tomohiro , Tsuchiya Naho , Nakaya Naoki , Murakami Keiko , Ueno Fumihiko , Onuma Tomomi , Ishikuro Mami , Obara Taku , Mugikura Shunji , Tomita Hiroaki , Uruno Akira , Kobayashi Tomoko , Tsuboi Akito , Tadaka Shu , Katsuoka Fumiki , Narita Akira , Sakurai Mika , Makino Satoshi , Tamiya Gen , Aoki Yuichi , Shimizu Ritsuko , Motoike Ikuko N. , Koshiba Seizo , Minegishi Naoko , Kumada Kazuki , Nobukuni Takahiro , Suzuki Kichiya , Danjoh Inaho , Nagami Fuji , Tanno Kozo , Ohmomo Hideki , Asahi Koichi , Shimizu Atsushi , Hozawa Atsushi , Kuriyama Shinichi ,   the Tohoku Medical Megabank Project Study Group, Yamamoto Masayuki , Abe Michiaki , Aizawa Yayoi , Aoki Yuichi , Chida Koichi , Danjoh Inaho , Egawa Shinichi , Eto Ai , Funayama Takamitsu , Fuse Nobuo , Hamanaka Yohei , Harada Yuki , Hashizume Hiroaki , Higuchi Shinichi , Hirano Sachiko , Hirata Takumi , Hiratsuka Masahiro , Hozawa Atsushi , Igarashi Kazuhiko , Inoue Jin , Ishida Noriko , Ishii Naoto , Ishii Tadashi , Ishikuro Mami , Ito Kiyoshi , Ito Sadayoshi , Kageyama Maiko , Katsuoka Fumiki , Kawame Hiroshi , Kawashima Junko , Kikuya Masahiro , Kinoshita Kengo , Kitatani Kazuyuki , Kiyama Tomomi , Kiyomoto Hideyasu , Kobayashi Tomoko , Kodama Eiichi , Kogure Mana , Kojima Kaname , Koreeda Sachie , Koshiba Seizo , Koyama Shihoko , Kudo Hisaaki , Kumada Kazuki , Kure Shigeo , Kuriki Miho , Kuriyama Shinichi , Kuroki Yoko , Maikusa Norihide , Makino Satoshi , Matsubara Hiroko , Matsui Hiroyuki , Metoki Hirohito , Mimori Takahiro , Minegishi Naoko , Misawa Kazuharu , Miyashita Masako , Mizuno Satoshi , Motohashi Hozumi , Motoike Ikuko N. , Nagaie Satoshi , Nagai Masato , Nagami Fuji , Nagasaki Masao , Nagase Sachiko , Nakamura Naoki , Nakamura Tomohiro , Nakaya Naoki , Nakayama Keiko , Narita Akira , Nishijima Ichiko , Nobukuni Takahiro , Nochioka Kotaro , Obara Taku , Ogishima Soichi , Ohuchi Noriaki , Olivier Gervais , Osumi Noriko , Otsu Hiroshi , Otsuki Akihito , Saigusa Daisuke , Saito Sakae , Saito Tomo , Sakaida Masaki , Sakurai-Yageta Mika , Sato Yuki , Sato Yukuto , Sekiguchi Atsushi , Shen Chen-Yang , Shibata Tomoko F. , Shimizu Ritsuko , Shimokawa Kazuro , Shirota Matsuyuki , Sugawara Junichi , Suzuki Kichiya , Suzuki Yoichi , Tadaka Shu , Taira Makiko , Takai-Igarashi Takako , Takano Yuji , Taki Yasuyuki , Tamiya Gen , Tanabe Osamu , Tanaka Hiroshi , Tanaka Yukari , Teraguchi Shunsuke , Terakawa Takahiro , Tominaga Teiji , Tomita Hiroaki , Tsuboi Akito , Tsuchiya Naho , Tsuji Ichiro , Ueki Masao , Uruno Akira , Yaegashi Nobuo , Yamagishi Junya , Yamaguchi-Kabata Yumi , Yamanaka Chizuru , Yamashita Riu , Yasuda Jun , Yokozawa Junji , Waki Kazunori , Sasaki Makoto , Akai Junko , Endo Ryujin , Fukushima Akimune , Furukawa Ryohei , Hachiya Tsuyoshi , Hashizume Kouhei , Hitomi Jiro , Ishigaki Yasushi , Komaki Shohei , Kotozaki Yuka , Mikami Takahiro , Nakamura Motoyuki , Nishiya Naoyuki , Nishizuka Satoshi , Nomura Yoko , Ogasawara Kuniaki , Ohmomo Hideki , Omama Shinichi , Otomo Ryo , Otsuka Kotaro , Oyama Kotaro , Sakata Kiyomi , Sasaki Ryohei , Satoh Mamoru , Sato Namie , Shimizu Atsushi , Shiwa Yu , Sutoh Yoichi , Takanashi Nobuyuki , Takebe Noriko , Tanaka Fumitaka , Tanaka Ryoichi , Tanno Kozo , Tokutomi Tomoharu , Yamamoto Kayono , Yamashita Fumio , Fuse Nobuo , Tominaga Teiji , Kure Shigeo , Yaegashi Nobuo , Kinoshita Kengo , Sasaki Makoto , Tanaka Hiroshi , Yamamoto Masayuki 
Published: December 2021

AbstractTo reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called “dbTMM” that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.