bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traffic analysis for 5G network slice based on machine learning
Authors: Xie Feng , Wei Dongxue , Wang Zhencheng 
Published: April 2021

AbstractWith the rise of 5G and Internet of things, especially the key technology of 5G, network slice cuts a physical network into multiple virtual end-to-end networks, each of them can obtain logically independent network resources to support richer services. 5G mobile data and sensor data converge to form a growing network traffic. Traffic explosion evolved into a mixed network type, and network viruses, worms, network theft and malicious attacks are also involved. How to distinguish traffic types, block malicious traffic and make effective use of sensor data under the background of 5G network slice, and also the significance of this study.
Matrix iteration algorithms for solving the generalized Lyapunov matrix equation
Authors: Zhang Juan , Kang Huihui , Li Shifeng 
Published: April 2021

AbstractIn this paper, we first recall some well-known results on the solvability of the generalized Lyapunov equation and rewrite this equation into the generalized Stein equation by using Cayley transformation. Then we introduce the matrix versions of biconjugate residual (BICR), biconjugate gradients stabilized (Bi-CGSTAB), and conjugate residual squared (CRS) algorithms. This study’s primary motivation is to avoid the increase of computational complexity by using the Kronecker product and vectorization operation. Finally, we offer several numerical examples to show the effectiveness of the derived algorithms.
The validity and reliability of a digital Ruff Figural Fluency Test (RFFT)
Authors: Vrijsen J. , van Erpecum C. L. , de Rooij S. E. , Niebuur J. , Smidt N. 
Published: April 2021

Abstract
Background
The Ruff Figural Fluency Test (RFFT) is a valid but time-consuming and labour-intensive cognitive paper-and-pencil test. A digital RFFT was developed that can be conducted independently using an iPad and Apple Pencil and RFFT scores are computed automatically. We investigated the validity and reliability of this digital RFFT.

Methods
We randomly allocated participants to the digital or paper-and-pencil RFFT. After the first test, the other test was performed immediately (cross-over). Participants were invited for a second digital RFFT 1 week later. For the digital RFFT, an (automatic) algorithm and two independent raters (criterion standard) assessed the number of unique designs (UD) and perseverative errors (PE). These raters also assessed the paper-and-pencil RFFT. We used Intraclass correlation coefficients (ICC), sensitivity, specificity, %-agreement, Kappa, and Bland–Altman plots.

Results
We included 94 participants (mean (SD) age 39.9 (14.8), 73.4% follow-up). Mean (SD) UD and median (IQR) PE of the digital RFFT were 84.2 (26.0) and 4 (2–7.3), respectively. Agreement between manual and automatic scoring of the digital RFFT was high for UD (ICC = 0.99, 95% CI 0.98, 0.99, sensitivity = 0.98; specificity = 0.96) and PE (ICC = 0.99, 95% CI 0.98, 0.99; sensitivity = 0.90, specificity = 1.00), indicating excellent criterion validity. Small but significant differences in UD were found between the automatic and manual scoring (mean difference: − 1.12, 95% CI − 1.92, − 0.33). Digital and paper-and-pencil RFFT had moderate agreement for UD (ICC = 0.73, 95% CI 0.34, 0.87) and poor agreement for PE (ICC = 0.47, 95% CI 0.30, 0.62). Participants had fewer UD on the digital than paper-and-pencil RFFT (mean difference: − 7.09, 95% CI − 11.80, − 2.38). The number of UD on the digital RFFT was associated with higher education (Spearman’s r = 0.43, p < 0.001), and younger age (Pearson’s r = − 0.36, p < 0.001), showing its ability to discriminate between different age categories and levels of education. Test–retest reliability was moderate (ICC = 0.74, 95% CI 0.61, 0.83).

Conclusions
The automatic scoring of the digital RFFT has good criterion and convergent validity. There was low agreement between the digital RFFT and paper-and-pencil RFFT and moderate test–retest reliability, which can be explained by learning effects. The digital RFFT is a valid and reliable instrument to measure executive cognitive function among the general population and is a feasible alternative to the paper-and-pencil RFFT in large-scale studies. However, its scores cannot be used interchangeably with the paper-and-pencil RFFT scores.
Impact of structured physical therapy intervention on functional recovery in a patient with CAPOS syndrome: a case report
Authors: Gardas Shailesh , Mahajan Aishwarya 
Published: April 2021

Abstract
Background
CAPOS syndrome (cerebellar ataxia, areflexia, pescavus, optic atrophy, and sensorineural hearing loss) is a rare congenital autosomal dominant disorder. The resulting neurological sequelae of impairments are progressive in nature and may interfere with functional independence, performing activities of daily living (ADL’s), and subsequently, affecting the quality of life (QOL). Since it is an extremely rare disorder, there is a severe dearth in the literature about how specific physiotherapy interventions may affect their functional status. Therefore, our objective was to investigate the effects of proprioceptive neuromuscular facilitation (PNF) and Frenkel’s coordination exercises on functional recovery in a patient with CAPOS syndrome.

Case presentation
We herein present a case of a 25-year-old Indian male with complaints of generalized body weakness, difficulty visualizing distant objects, nystagmus, progressive sensorineural deafness, and ataxia. He was rehabilitated with a structured/customized physiotherapy protocol consisting of PNF approach and coordination exercises for 4 weeks, 6 days/week, 60 min daily. An improvement in overall functional performance of patient as per post-intervention scores of manual muscle testing, trunk control measurement scale, functional independence measure (components of self-care, transfers, and locomotion), and decline in severity of ataxia on scale for assessment and rating of ataxia scale was observed.

Conclusion
PNF and Frenkel’s exercises resulted in an improvement in overall functional performance of the patient. Improvement was observed in post-test scores of Manual Muscle Testing (MMT), Trunk Control Measurement Scale (TCMS), and Functional Independence Measure (FIM) for the components of self-care, transfers, and locomotion. Additionally, results also showed a decline in severity of ataxia on post-test scores of scale for the assessment and rating of ataxia (SARA) scale (i.e., from severe to moderate).
Contributions to the American Society of Hematology Meeting From Low- and Middle-Income Countries: An In-Depth Analysis and Call to Action
Authors: Gómez-De León Andrés , Colunga-Pedraza Perla R. , Tarín-Arzaga Luz , Bugarín-Estrada Emmanuel , Sung Lilian , Cantú-Martínez Omar , Jaime-Pérez José C. , Gómez-Almaguer David 
Published: April 2021

PURPOSE: Establishing research capacity in low- and middle-income countries (LMICs) is key for improving the outcomes of patients with hematologic diseases globally. Few studies have analyzed the contributions of LMICs to global hematology. The American Society of Hematology Meeting (ASH) is the largest international academic event where peer-reviewed contributions in our field are presented. METHODS: In this cross-sectional analysis, all abstracts accepted to ASH 2018 selected for a poster or oral presentation were reviewed. Those that had a contributing author from an LMIC were identified. The proportion of LMIC abstracts across categories was analyzed. Country of origin, high-income country participation, the presence of a conflict of interest (COI), and sponsorship were determined. RESULTS: From 4,871 abstracts reviewed, 506 had a contributing author from an LMIC (10.4%), with 277 (54.7%) contributions in partnership with a high-income country. LMIC-independent contributions corresponded to 19 of 1,026 oral abstracts (1.9%) and 209 of 3,845 posters (5.4%). Most abstracts from LMICs were clinical (n = 311; 61.5%) and multicentric in nature (n = 353; 69.8%). COI statements with the pharmaceutical industry were common (n = 214; 42.3%). Collaboration between LMICs was infrequent (n = 33; 6.5%). Upper-middle–income countries had 466 participations (81.5%), in comparison with 96 (16.8%) in low-middle–income and 10 (1.7%) in low-income countries. CONCLUSION: LMICs were responsible for a small fraction of abstracts at ASH18; low-income countries were practically absent. Almost half of accepted works represented a form of international collaboration, with clinical, multicenter studies predominating and COI disclosures a frequent and unexpected feature, reflecting the instrumental nature of LMIC participation and a lack of independent, robust, locally developed hematology research.
Testicular germ cell tumors arise in the absence of sex-specific differentiation
Authors: Webster Nicholas J. , Maywald Rebecca L. , Benton Susan M. , Dawson Emily P. , Murillo Oscar D. , LaPlante Emily L. , Milosavljevic Aleksandar , Lanza Denise G. , Heaney Jason D. 
Published: April 2021

ABSTRACT
In response to signals from the embryonic testis, the germ cell intrinsic factor NANOS2 coordinates a transcriptional program necessary for the differentiation of pluripotent-like primordial germ cells toward a unipotent spermatogonial stem cell fate. Emerging evidence indicates that genetic risk factors contribute to testicular germ cell tumor initiation by disrupting sex-specific differentiation. Here, using the 129.MOLF-Chr19 mouse model of testicular teratomas and a NANOS2 reporter allele, we report that the developmental phenotypes required for tumorigenesis, including failure to enter mitotic arrest, retention of pluripotency and delayed sex-specific differentiation, were exclusive to a subpopulation of germ cells failing to express NANOS2. Single-cell RNA sequencing revealed that embryonic day 15.5 NANOS2-deficient germ cells and embryonal carcinoma cells developed a transcriptional profile enriched for MYC signaling, NODAL signaling and primed pluripotency. Moreover, lineage-tracing experiments demonstrated that embryonal carcinoma cells arose exclusively from germ cells failing to express NANOS2. Our results indicate that NANOS2 is the nexus through which several genetic risk factors influence tumor susceptibility. We propose that, in the absence of sex specification, signals native to the developing testis drive germ cell transformation.
An Update on Simple Elbow Dislocations: A Protocol for Early Return to Sport in High School Wrestlers
Authors: Barton Dane , DeSilva Gregory 
Published: April 2021

Abstract
The principles and management of simple elbow dislocations have evolved over time. In the past, a conservative approach of immobilization and slow rehabilitation were used. More modern treatments emphasize an understanding of the soft tissues about the elbow joint and prescribe an aggressive approach to regaining motion. Elbow stiffness is a common effect of the injury. We outline our treatment principles in a series of high school wrestlers with simple elbow dislocation. The ultimate goal is to return to sport in a safe but early timeframe. We recommend a brief period of immobilization with close follow-up and no motion restrictions after immobilization is removed. This review and case series emphasize the importance of aggressive but safe return to sport in high school wrestlers with an elbow dislocation.
Measuring the Feasibility and Effectiveness of an Individualized Exercise Program Delivered Virtually to Cancer Survivors
Authors: Wonders Karen Y. , Gnau Kara , Schmitz Kathryn H. 
Published: April 2021

Abstract
In the spring of 2020, we faced a global pandemic that resulted in social distancing limitations not previously experienced, forcing practitioners to adapt exercise programming to a virtual model. The purpose of this investigation was to measure the effectiveness of a virtual exercise oncology program in 491 participants undergoing antineoplastic therapy between March and June 2020. Each session was completed virtually with a certified exercise oncology trainer. Fitness and psychological parameters were measured preexercise and postexercise intervention. Overall, participants completed 4949 of 5892 prescribed exercise sessions. Patients saw increases in cardiovascular endurance (15.2%, P < 0.05), muscular endurance (18.2%, P < 0.05), flexibility (31.9%, P < 0.05), feelings of support (58.7%, P < 0.05), and quality of life (32.2%, P < 0.05), as well as decreases in loneliness (54%, P < 0.05) and fatigue (48.7%, P < 0.05). In light of our findings, we assert that virtual exercise training is a viable option in circumstances where in-person, individualized exercise training is not possible.
How to visualise the unvisible – new video-based eyetracking paradigm "PILK!" for children aged 3 to 4
Authors: Saareoja Helen , Kaldoja Mari-Liis 
Published: April 2021

Sotsiaalselt pädev laps märkab ja tõlgendab eri suhtlusstiimuleid ning suudab nende järgi arvestada oma suhtluspartneriga ja valida sobivad suhtluseesmärgid. Raskused stiimulite märkamisel ja tõlgendamisel võib olla aga üks põhjustest, miks laps käitub mõnes suhtlussituatsioonis ebasobivalt. Sotsiaalset pädevust hindavad hindamisvahendid üldiselt kinnitavad probleemi sotsiaalsetes suhtlusolukordades toimetulemisel, kuid ei anna teavet selle kohta, mis on nimetatud raskuste põhjus, ega ka selle kohta, kuhu suunata teraapia fookus. Selle tühimiku täitmiseks koostati 2017–2018. aastal 12 originaalvideost koosnev sotsiaalse taju hindamise vahend "PILK!", millega saab hinnata, kuidas laps sõltuvalt kontekstist fikseerib pilgu olulistele mitteverbaalsetele suhtlussignaalidele (pilgu suund, žestid, emotsioonid, vooruvahetus). Siinne esmauuring näitas, et koostatud hindamisvahendi videotes määratud huvipiirkonnad on suuresti sobilikud hindamaks, kuidas 3–4aastased lapsed pööravad tähelepanu sotsiaalselt olulistele stiimulitele. Uuringu tulemustest selgus, et parema probleemilahenduse oskustega lapsed fikseerisid enam pilku sotsiaalselt olulistele stiimulitele. Pilgu fikseerimise muster sõltus video kontekstist – enam tähelepanu sai inimese nägu, emotsiooni ja reaktsiooni väljendav nägu, tegevus ja sellega kaasnev objekt ning sümboolsed žestid.
Summary
The Pre-clinical Test’s Results of the Efficiency of the Radiopharmaceutical Preperation "DTPA-Microspheres of Albumin, 90Y"
Authors: Vlasova O , Stepchenkova E , Petriev V , Klement'eva O. , Stepchenkov D , Krasnoperova A , Kuznetsov Aleksey , Nerozin N , Ivanov S , Kaprin A. 
Published: April 2021

Purpose: Development of technology for producing a radiopharmaceutical based on 90Y labeled modified human blood albumin microspheres, and the study of the functional suitability of this drug in experimental animals.
Material and methods: The research team studied the following characteristics of the drug: the distribution and excretion of the drug after its intra-arterial administration; the mechanism of action of the drug in animals with model pathology; therapeutic efficacy of the drug in animals with a liver tumor model.
The following physicochemical characteristics of the developed radiopharmaceutical were announced: modified with DTPA and labeled 90Y human blood albumin microspheres, particle size 25-40 microns, radiochemical impurities less than 5.0%, 90Sr radionuclide impurities less than 0.002%, the amount of chemical impurities (Na, Al, Ca, Fe, Cu, Zn, Cd, Pb) not more than 10 μg / GBq, volumetric activity up to 150 mCi / ml at the date of preparation.
Sprague Dawley female rats were taken as experimental animals (body weight 220-260 g). Studies were conducted on a model pathology - hepatocellular carcinoma, which occurs in 85% of all malignant tumors of the human liver.
Results: in 2018-2019, nine pilot batches of the radiopharmaceutical product satisfying the declared characteristics were developed. Stable inhibition of the growth of tumor lesions by 7.62% was noted. The quality of life in animals with orthotopic tumor foci of hepatocarcinoma treated was better than in animals not treated. Life expectancy in the group of animals treated with the drug was higher than in the group of animals that did not receive treatment by 7.1%. The distribution of the drug was characterized by pulmonary bypass, not exceeding 9% of the injected activity and minimal forwarding into the circulating blood. The radiopharmaceutical was firmly held at the injection site and remained almost unchanged throughout the study. Binding to the tumor site of the drug was characterized by retention of at least 78% of the introduced activity.
Conclusion: Conducted preclinical studies of the pharmacokinetics of the drug show its potential suitability for the treatment of liver cancer by radionuclide embolization. According to the results of preclinical studies of the therapeutic effectiveness of the radiopharmaceutical, it should be considered effective for use.
PERSEPSI KONSUMEN DI KALANGAN MAHASISWA DAN MASYARAKAT UMUM TERHADAP PONSEL PINTAR MEREK BLACKBERRY DI YOGYAKARTA
Authors: Adabi Azhar , Setyono Hendro 
Published: April 2021

This study titled consumer perceptions among students and the general public against the Blackberry smart phone brand in the Jogjakarta. This study aims to determine whether there are difference among students in the consumer and the general public on smart phones. The research was conducted in Yogyakarta in particular by using a questionnaire, each of 50 respondents who were sampled. By using the technique of sampling, snowball sampling. Analysis of test data used in the arithmetic mean statistic. From the survey results revealed that consumer perceptions of brand smart phone blackberry is positive, where the perception among students is better than the consumer’s perception among the general public. From the analysis of hypothesis testing concluded that the probability of > significance () means there is no difference among students in the consumer and the general public on blackberry smart phone brand. The price of smart phone based on the attribute probability value 0.540. While the quality attributes of a smart phone probability value of 0.149. And attribute value of the probability models of smart phones 0.638
PENGARUH KUALITAS PRODUK TERHADAP KEPUASAN KONSUMEN DAN KESETIAAN MEREK PADA PRODUK TOLAK ANGIN CAIR SIDOMUNCUL
Authors: Darnawati Dhewi Andria , Sutanto Aftoni 
Published: April 2021

This study aims to determine how the effect of product quality to customer satisfaction and customer loyalty on the product Tolak Angin Cair Sidomuncul and to find out what is the most dominant variable affecting consumer satisfaction and brand loyalty to the product of Tolak Angin Cair Sidomuncul. The population in this study is that people in the District of Umbulharjo, the city of Yogyakarta. Sampling techniques used is incidental sampling. Sources of data from this study using primary data obtained from the deployment questionnaire. This study used data analysis techniques are qualitative and quantitative analysis (multiple regression analysis, t test and F test). T test results on customer satisfaction (Y1) show that for each of the performance variables (X1), Reliability (X2), Endurance (X3), Aesthetics (X4), and perceived quality (X5) obtained the calculated value of t-count> t-table. It can be concluded that the performance variables (X1), aesthetics (X4), the perceived quality (X5), the partial effect is not significant and, while the variables Reliability (X2), Endurance (X3) and significant effect on customer satisfaction and t test results on brand loyalty disimpilkan that performance (X1), Reliability (X2), Endurance (X3), Aesthetics (X4), partial and no significant effect, whereas the perceived quality variables (X5) of consumer loyalty to the product Tolak Angin Sidomuncul. The results of the F test, F-table obtained = 5% F-count on the consumer satisfaction of 7.420. While the F-count on brand loyalty of 16.728. Because the F-count value. F-table, then the performance of independent variables (X1), Reliability (X2), Endurance (X3), Aesthetics (X4), and perceived quality (X5) simultaneously affect consumer satisfaction and brand loyalty to the product of Tolak Angin Cair Sidomuncul.
PENGARUH KURS RUPIAH, TINGKAT SUKU BUNGA, DAN TINGKAT PENGANGGURAN TERHADAP HARGA SAHAM PADA PERUSAHAAN SUB SEKTOR PERTAMBANGAN MINYAK DAN GAS BUMI YANG TERCATAT DI BURSA EFEK INDONESIA PERIODE 2012-2017
Authors: Dewi Atika Puspita , Asakdiyah Salamatun 
Published: April 2021

The monetary situation and the movement of macroeconomic variables are things that must be considered an investor in the stock trading activity in a country. The economic situation and fluctuations in macro variables in one country can affect the stock price, including the oil and gas mining sub-sector. This study aimed to examine the effect of macroeconomic variables, namely exchange rate, interest rate, and unemployment rate to stock prices. This study uses quantitative methods. The population in this study are all oil and gas mining sub-sector companies listed in Indonesia Stock Exchange in the period 2012-2017. Sample selection technique is by using purposive sampling method. Based on predetermined criteria, acquired 7 oil and gas mining sub-sector companies sampled in this study. Data analysis techniques in this study using multiple linear regression analysis. The results showed that the variables simultaneously exchange rate, interest rate, and unemployment rate significant effect on stock price of oil and gas mining sub-sector companies. Partially, variable Exchange Rate and Interest Rate was a significant influence on stock price, while the variable Unemployment Rates no significant influence on stock price.
PENGARUH EARNING PER SHARE, DEBT TO EQUITY RATIO, RETURN ON EQUITY, DAN CURRENT RATIO TERHADAP PRICE TO BOOK VALUE PERUSAHAAN SUB SEKTOR ADVERTISING PRINTING MEDIA YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2014-2017
Authors: Maudy Mutiara Via , Ismanto Deny 
Published: April 2021

This study aims to examine the effect of Earning Per Share, Debt To Equity Ratio, Return On Equity and Current Ratio to Price to Book Value on advertising printing media companies listed on the Indonesia Stock Exchange for the period 2014-2017. This research is descriptive quantitative research. The research population is all advertising printing media companies listed on the Indonesia Stock Exchange for the period 2014-2017 with a total of 15 companies. The sample selection was determined by purposive sampling technique with the criteria of the stock being sampled were the companies that published theirfinancial statements during the consecutive research year, so that samples are 12 companies were obtained. This study uses a statistical panel data regression analysis tool. The results of the study using Earning Per Share, Debt To Equity Ratio, Return On Equity and Current Ratio to Price to Book Value have results, the Debt To Equity Ratio variable affects the dependent variable Price to Book Value, while the other independent variables have no effect, that is; Earning Per Share, Return On Equity and Current Ratio. With the value of R Squared of 66.5% which explains the large influence on Price to Book Value.