bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Protocol for Treatment of Avabahuk (Frozen Shoulder) with Agnikarma and Topical Diclofenac Sodium Gel
Authors: Kumar Mahesh , Shinde R. K. , Jaiswal Reena 
Published: June 2021

Background: The Avabahuk is a disease described in ancient Ayurveda and is correlated with frozen shoulder of modern science. It is mainly due to vatadosha prakopa and the treatment adopted for this are for snayu-sandhi-asthi-gata-vata. Many treatment modalities mentioned in Ayurveda for treatment of Avabahuka. The treatment modality Agnikarma, the intentional therapeutic heat burn therapy is one among them.
Aim and objectives: The aim of the study is to compare efficacy of Agnikarma and topical Diclofenac sodium gel in Avabahuk (Frozen shoulder) treatment.
Methodology: The sample size will decide in pilot study and the patients will randomly divided equally into 2 groups. In Group A (Interventional) the Agnikarma will be done at weekly interval for 4 weeks along with physiotherapy. In Group B (comparator group) the topical diclofenac sodium gel application for 4 weeks with physiotherapy.
Results: The changes will observed and record in objective outcomes.
Conclusion: Agnikarma will be effective in lowering the pain and stiffness of frozen shoulder.
Development and Validation of a New RP-HPLC Analytical Method for the Simultaneous Determination of Luliconazole and Clobetasol Propionate in Synthetic Mixture
Authors: Solanki Binal , Joshi Hirak 
Published: June 2021

Aim: To develop new selective and sensitive reverse-phase high-performance liquid chromatography (RP-HPLC) approach for the quantification of antifungal drug Luliconazole integrate with corticosteroid drug Clobetasol Propionate in a synthetic mixture.
Methods: The method was validated to achieve International Conference Harmonization (ICH) requirements. Chromatographic separation was carried out by isocratic technique on a reversed-phase Inertsil C18 column (5 µm, 250mm x 4.6mm i.d with the mixture of Acetonitrile: Water pH adjusted with H3PO4 (60: 40) and UV detection at 264 nm. The compounds were eluted at a flow rate of 1.0 mL/min with an injection volume of 20μL.
Results: The calibration curves were linear (r2 > 0.999) over the concentration range 10-200 μg/mLfor Luliconazole and 5-100 μg/mL for Clobetasol Propionate. The average retention times for Luliconazole and Clobetasol Propionate were 3.16 and 6.94 min, respectively. The % RSD for the proposed method was found to be less than %2. The % recovery was found to between 99.22-99.48% for the developed method.
Conclusion: The developed method is simple, rapid, precise, and accurate and hence was successfully applied for the determination of Luliconazole and Clobetasol Propionate in a synthetic mixture.
Assessment of the Association between Hypertention & Body Mass Index in Patients Visiting at Department of Medicine Pmch Nawabshah
Authors: Sial Sikander Ali , Kumar Jagdesh , Ayoob Attia , Jamali Anwar Ali , Dahri Amir Hamzo , Ali Sanum , Ahmer Arslan 
Published: June 2021

Background: Hypertension is a common health issue all over the world; increased Body Mass Index (BMI) is alone one strong risk factor for the HTN.
Objective: To assess the relationship between HTN & BMI in patients visited at department of Medicine PMCH Nawabshah.
Methodology: This cross sectional study was conducted at PMC Hospital Nawabshah during March 2019 to February 2020. Sample size was 385. This study was conducted after ethical approval of institutional committee and willing male and female subjects with hypertension were included in present study after consent. Age ranges from 15 years and above. Those having other co morbidities like, DM, IHD, stroke and other metabolic and endocrine disorders were excluded from the study. Patients with history of drugs causing weight gain were also excluded.
Results: there were total 385 subjects included, 130 were females and 245 were males1:2 ratio of female and male. Mean age of patients was 46.50 sd ± 8.65 years, mean BMI was 26.18 sd ± 4.73, mean systolic HTN was158.35sd ± 30.40 and mean diastolic blood pressure was 95.75 sd ± 12.91 mmHg.
Conclusion: There is strong association between hypertension and BMI, as the BMI will increase the risk of HTN will increase.
A Prospective Study on Clinico-Radiological Correlation and Conservative Management of Non-Traumatic Acute Abdomen at a Tertiary Care Centre
Authors: Mahawar Rajat , Chandak Suresh , Yeola Meenakshi 
Published: June 2021

Background: Acute abdomen is a condition in which the patient complains of a sudden or gradual attack of abdominal pain over a duration of several hours and presents with a set of symptoms which indicatea life threateningillness that needs an urgent or quick diagnosis for early treatment. Delay in diagnosis will worsen the condition of the patient and can even have a fatal outcome. It is crucial to recognize situations where laparotomy can be avoided in order to bring down morbidity and financial costs. Hence this study is being conducted to evaluate various clinical presentations, accuracy of clinical diagnosis, causes, better imaging studies and effectiveness of conservative management of non-traumatic acute abdomen.
Objectives:

To study various clinical presentation of non-traumatic acute abdomen.
To study the accuracy of clinical diagnosis of non-traumatic acute abdomen
To study different causes of acute abdomen.
Compare different imaging studies in cases of acute abdomen and to evaluate their accuracy in diagnosing the condition.
To study the effectiveness of conservative management (OchsnerScherren regimen) in cases of acute abdomen.

Methods: The study will be doneat Dept. of General Surgery, J.N.M.C and AVBRH, Wardha. The duration of the study will be 2 years from September 2020 to August 2022. In this study, 80-100 Patients of acute abdomen attending the routine OPD and Emergency room at AVBR Hospital will be studied. Thorough clinical examination will be done and Patients with Abdominal pain will be categorized according to inclusion and exclusion criteria. Clinical findings with Radiological findings will be correlated and the sensitivity of imaging studies in diagnosing acute abdomen will be evaluated. The outcome of conservative management of non-traumatic acute abdomen will be observed.
Results: We expectto study various clinical presentations of acute abdomen, causes, evaluate the accuracy of imaging studies and to study the effectiveness of conservative management all of which in turn would lead to early and better management of acute abdomen.
Conclusion: Better understanding about presentation, causes, the accuracy of radiological studies and effectiveness of conservative management would help in identification of cases in which laparotomy can be avoided to prevent unnecessary surgery with its associated morbidity and financial burden.
MRI Evaluation of Seizures in Pediatric Age Group Patients in a Rural Hospital of Central India
Authors: Raj Nishant , Dhande Rajasbala Pradeep 
Published: June 2021

Background: Seizures are a common presenting complaint in pediatric patients. There are many underlying causes which may present as seizures in pediatric population, for example: febrile seizures, hypoxic ischemic encephalopathy, congenital malformations, certain neoplasms etc. Magnetic resonance imaging(MRI) plays a fundamental role in evaluation of these causes and is especially of use in identifying the structural lesions presenting as seizures.
Objectives: To assess the role of MRI(1.5 Tesla) in evaluation pediatric seizures and to study spectrum of MRI findings associated with various causes.
Methodology: A prospective study will be conducted at “Acharya Vinoba Bhave Rural Hospital, Sawangi”, involving 138 pediatric patients coming to Radiology department.
Results: After statistical analysis, we expect to find effectiveness of MRI in evaluation of pediatric seizures.
Conclusion: In this study we expect to find usefulness of MRI as a diagnostic tool in assessment of pediatric seizures especially in those with structural lesions.
Comparative Study between Open Surgical Drainage and Closed Technique of Percutaneous Aspiration under Image Guidance for Management of Breast Abscess
Authors: Rathi Chetna Dilip , Yeola (Pate) Meenakshi 
Published: June 2021

Background: The conventional surgical management of breast abscesses consists of an incision taken over the point at which there is maximum fluctuation (or pain) and breaking of the abscess septa by digits. Now antibiotics and repeated abscess aspiration under USG guidance is new minimally invasive method which is on rise
Objectives:

To study the outcome of open technique of breast abscess management.
To study the outcome of closed technique of breast abscess management.
To compare the outcome of open v/s closed technique of surgical management of breast abscess.

Methodology: Sample will be divided into two groups and type of treatment i.e open incision and drainage or percutaneous aspiration under guidance will be decided randomly by chit system.
Expected Results: Feasibility and outcome of Percutaneous drainage is better than incision and drainage
Conclusion: First line management of Breast abscess will soon be percutaneous drainage under USG guidance.
Development of a physical geometric phantom for deformable image registration credentialing of radiotherapy centers for a clinical trial
Authors: Kadoya Noriyuki , Sakulsingharoj Siwaporn , Kron Tomas , Yao Adam , Hardcastle Nicholas , Bergman Alanah , Okamoto Hiroyuki , Mukumoto Nobutaka , Nakajima Yujiro , Jingu Keiichi , Nakamura Mitsuhiro 
Published: June 2021

AbstractPurposeThis study aimed to develop a physical geometric phantom for the deformable image registration (DIR) credentialing of radiotherapy centers for a clinical trial and tested the feasibility of the proposed phantom at multiple domestic and international institutions.Methods and materialsThe phantom reproduced tumor shrinkage, rectum shape change, and body shrinkage using several physical phantoms with custom inserts. We tested the feasibility of the proposed phantom using 5 DIR patterns at 17 domestic and 2 international institutions (21 datasets). Eight institutions used the MIM software (MIM Software Inc, Cleveland, OH); seven used Velocity (Varian Medical Systems, Palo Alto, CA), and six used RayStation (RaySearch Laboratories, Stockholm, Sweden). The DIR accuracy was evaluated using the Dice similarity coefficient (DSC) and Hausdorff distance (HD).ResultsThe mean and one standard deviation (SD) values (range) of DSC were 0.909 ± 0.088 (0.434–0.984) and 0.909 ± 0.048 (0.726–0.972) for tumor and rectum proxies, respectively. The mean and one SD values (range) of the HD value were 5.02 ± 3.32 (1.53–20.35) and 5.79 ± 3.47 (1.22–21.48) (mm) for the tumor and rectum proxies, respectively. In three patterns evaluating the DIR accuracy within the entire phantom, 61.9% of the data had more than a DSC of 0.8 in both tumor and rectum proxies. In two patterns evaluating the DIR accuracy by focusing on tumor and rectum proxies, all data had more than a DSC of 0.8 in both tumor and rectum proxies.ConclusionsThe wide range of DIR performance highlights the importance of optimizing the DIR process. Thus, the proposed method has considerable potential as an evaluation tool for DIR credentialing and quality assurance.
New hemodynamic criteria to separate classical orthostatic hypotension from vasovagal syncope
Authors: Ghariq Maryam , Kerkhof Fabian I. , Reijntjes Robert H. , Thijs Roland D. , van Dijk J. Gert 
Published: June 2021

AbstractObjectiveTo define and evaluate hemodynamic criteria to distinguish between classical orthostatic hypotension (cOH) and vasovagal syncope (VVS) in tilt table testing (TTT).MethodsInclusion criteria for VVS were a history of VVS and tilt‐induced syncope defined as a blood pressure (BP) decrease and electroencephalographic changes during syncope with complaint recognition. Criteria for cOH were a history of cOH and a BP decrease meeting published criteria. Clinical diagnoses were established prior to TTT. We assessed (1) whether the decrease of systolic BP accelerated, “convex,” or decelerated, “concave”; (2) the time from head‐up tilt to when BP reached one‐half its maximal decrease; (3) the difference between baseline heart rate (HR) and HR at BP nadir. We calculated the diagnostic yield of optimized thresholds of these features and their combinations.ResultsWe included 82 VVS cases (40% men, median age 44 years) and 65 cOH cases (66% men, median age 70 years). BP decrease was concave in cOH in 79% and convex in VVS in 94% (p < 0.001). The time to reach half the BP decrease was shorter in cOH (median 34 sec, interquartile range (IQR) 19–98 sec) than in VVS (median 1571 sec, IQR 1381–1775 sec, p < 0.001). Mean HR increased by 11 ± 11 bpm in cOH and decreased by 20 ± 19 bpm in VVS (p < 0.001). When all three features pointed to VVS, sensitivity for VVS was 82% and specificity was 100%. When all three pointed to cOH, sensitivity for cOH was 71% and specificity was 100%.InterpretationThese new hemodynamic criteria reliably differentiate cOH from VVS.
Detrapping Current Measurement System Driven by Triboelectric Nanogenerators for Mapping Electron Trap States in Dielectrics
Authors: Wang Hanqing , Wang Jiyu , Liao Ruijin , Yang Lijun , Wu Han , Wang Zhong Lin 
Published: June 2021

AbstractElectron trap states characterization plays a vital role in mesoscale measurement. Previous destructive methods have been applicable only in qualitative comparison. Nonetheless, the imaging of trap states distribution in space and energy level remains challenging. Herein, a triboelectric nanogenerator driven detrapping current (TENGd‐DTC) measurement system is reported. The triboelectric nanogenerator (TENG) is designed as a high voltage generator, with an output voltage of ≈3 kV for driving the dielectric barrier discharge (DBD). The discharge model with dynamic carriers’ evolution is proposed, thus the detrapping currents can be extracted from DBD currents, based on which energy levels and densities of trap states are quantitatively calculated. The chamber design parameters as the platform for TENGd‐DTC measurement under DBD are optimized. With the optimized chamber, the energy level range within 0.6–0.8 eV can be clearly characterized, and the difference between results of the proposed and the current methods is less than 12%. More importantly, the improved measurement electrode array is applied for multi‐point scanning, and imaging of trap parameters is demonstrated vividly at a spatial resolution of ≈50 μm. This work paves an effective and non‐destructive imaging approach for trap states characterization, and potential applications in mesoscale modification of functional materials.
Intrinsically Stretchable Organic Solar Cells beyond 10% Power Conversion Efficiency Enabled by Transfer Printing Method
Authors: Wang Zhenye , Xu Meichen , Li Zhilin , Gao Yerun , Yang Lvpeng , Zhang Di , Shao Ming 
Published: June 2021

AbstractStretchable organic solar cells (OSCs) simultaneously possessing high‐efficiency and robust mechanical properties are ideal power generators for the emerging wearable and portable electronics. Herein, after incorporating a low amount of trimethylsiloxy terminated polydimethylsiloxane (PDMS) additive, the intrinsic stretchability of PTB7‐Th:IEICO‐4F bulk heterojunction (BHJ) film is greatly improved from 5% to 20% strain without sacrificing the photovoltaic performance. The intimate multi‐layers stacking of OSCs is also realized with the transfer printing method assisted by electrical adhesive “glue” D‐Sorbitol. The resultant devices with 84% electrode transmittance exhibit a remarkable power conversion efficiency (PCE) of 10.1%, which is among the highest efficiency for intrinsically stretchable OSCs to date. The stretchable OSCs also demonstrate the ultra‐flexibility, stretchability, and mechanical robustness, which keep the PCE almost unchanged at small bending radium of 2 mm for 300 times bending cycles and retain 86.7% PCE under tensile strain as large as 20% for the devices with 70% electrode transmittance. The results provide a universal method to fabricate highly efficient intrinsically stretchable OSCs.
3D‐Printed Underwater Super‐Oleophobic Shark Skin toward the Electricity Generation through Low‐Adhesion Sliding of Magnetic Nanofluid Droplets
Authors: Huang Jianyu , Wang Qi , Wu Zhenhua , Ma Zheng , Yan Chunze , Shi Yusheng , Su Bin 
Published: June 2021

AbstractSustainable energy supply by converting mechanical to electric energy is critical for flexible electronic technologies, soft robots, and biomedical applications. The development of magnetoelectric conversion approaches requires new strategies with lightweight, small, and portable features. To address this need, an underwater magnetic nanofluid droplet‐based generator (UMNDG) is designed to convert the mechanical energy of sliding droplets to electricity. The UMNDG consists of four parts: 3D‐printed underwater superoleophobic surface bioinspired by shark skin, oily magnetic nanofluid droplets, bottom coil, and magnetic part. By improving the manufacturing parameters of 3D‐printed shark skin, underwater superoleophobic and low‐adhesion surfaces can be fabricated, allowing for the magnetic nanofluid droplets to slide upon the surfaces freely. When the magnetic nanofluid droplets slide/leave the bottom coil/magnet region, the magnetic flux passes through the coil changes, yielding the generation of electricity. Maxwell simulation is used to study related working mechanism. Finally, a ladder‐type setup consisting of four UMNDGs is assembled in series, enabling to trigger the lighting of a LED bulb by continuous sliding of magnetic nanofluid droplets. Such a setup design may find use in a wide range of applications, from flexible electronic technologies to bio‐inspired materials that interface with magnetic nanofluid systems.
Wavelength‐Selective Organic Photodetectors
Authors: Vanderspikken Jochen , Maes Wouter , Vandewal Koen 
Published: June 2021

AbstractSpectroscopic sensing combined with optical imaging is crucial with respect to today's ever‐growing demand for instant analytical techniques to be incorporated in various handheld and wearable devices. Further miniaturization and integration of such types of sensors is critical and wavelength‐selective organic photodetectors (OPDs) may provide the required technology. In this progress report, some early OPD applications and their potential are presented. Crucial device parameters such as the specific detectivity, external quantum efficiency, and dark current density of visible and near‐infrared wavelength‐selective photodetectors are compared and assayed to theoretical and semi‐empirical limits. The different organic detector approaches include the use of inherently narrow‐band absorbers as well as internally filtered and microcavity devices. Each of these strategies comes with its own specific material and device design criteria, around which material development and selection should be centered to move beyond the current state of the art. As OPD technology matures, device stability becomes important and is hence also briefly discussed. Via this perspective, it is aimed to provide the reader with critical insights into the device physics and chemistry of wavelength‐selective OPDs, hereby providing leverage for new ideas to bring this technology to the market.
Regulating Ag Wettability via Modulating Surface Stoichiometry of ZnO Substrates for Flexible Electronics
Authors: Lee Taehyeong , Kim Daekyun , Suk Myung Eun , Bang Geumhyuck , Choi Jiyun , Bae Jong‐Seong , Yoon Jang‐Hee , Moon Won Jin , Choi Dooho 
Published: June 2021

AbstractA novel and highly efficient methodology to regulate (enhance or suppress) the Volmer–Weber 3D growth mode of ultra‐thin (<10 nm) Ag layers by modulating the surface stoichiometry of ZnO substrates prior to Ag deposition is presented. Relative to pristine ZnO layers, oxygen‐deficient surface states formed by preferential removal of surface oxygen atoms remarkably improve Ag layer wettability, whereas oxygen‐excessive surface states formed by oxygen atom incorporation strongly facilitate Ag agglomeration. The dissimilar nucleation and coalescence dynamics are elucidated via combined molecular dynamics and force‐bias Monte Carlo simulations. The improved wettability results in significantly lower sheet resistance in the ultra‐thin (6–10 nm) Ag layers, for example, 6.03 Ωsq−1 at 8 nm, than the previously reported values from numerous other approaches in the equal thickness range. When this unique methodology is applied to ZnO/Ag/ZnO transparent electrodes, simultaneous improvement in electrical conductivity and visible transparency is realized, with a resultant Haacke figure of merit value of 0.139 Ω−1 that is >50% higher than the best reported value for an identically structured electrode. We select transparent heating devices as a model system to confirm that the superior optoelectronic properties are highly sustainable under simultaneous and severe electrical, mechanical, and thermal stresses.
Spying on the Polarity Dynamics during Wound Healing of Zebrafish by Using Rationally Designed Carbon Dots
Authors: Hu Jingyu , Yang Ran , Qin Haoyue , Sun Yuanqiang , Qu Lingbo , Li Zhaohui 
Published: June 2021

AbstractWound healing is an essential and complex biological process. Research into its mechanism and factors that influence its effectiveness has led to better treatments. Changes in the microenvironment are demonstrated to affect wound healing. Cell polarity is a significant microenvironment‐related parameter that is associated with many physiological and pathological activities. However, dynamic changes in polarity during wound healing have not been investigated. Monitoring cell polarity during wound healing may open up a new avenue for developing better treatments. Here, a method is developed to monitor cell polarity that involved taking advantage of the fascinating optical properties and biocompatibility of carbon dots (CDs). Specifically, near‐infrared (NIR) polarity‐sensitive N‐phenyl‐p‐phenylenediamine (PPh‐CDs) are successfully prepared, which exhibit high sensitivity to polarity, with 509‐fold stronger fluorescence in dioxane than in water. The PPh‐CDs are successfully applied to monitor the changes of lysosomal polarity during starvation conditions. Using this method, dynamic changes of polarity during wound healing of zebrafish are monitored for the first time. Upon an amputation performed at the zebrafish tail, stronger PPh‐CDs fluorescence appeared at the wound sites, and the intensity increased for 25 min and then gradually decreased. This report provides an important experimental basis for investigating wound healing by employing polarity‐sensitive CDs.
A Concise Route to Cyclic Amines from Nitroarenes and Ketoacids under Iron‐Catalyzed Hydrosilylation Conditions
Authors: Wu Jiajun , Tongdee Satawat , Ammaiyappan Yuvaraj , Darcel Christophe 
Published: June 2021

AbstractStarting from nitroarenes, under hydrosilylation conditions, using a well‐defined N‐heterocyclic carbene iron(0) catalyst, (IMes)Fe(CO)4, the corresponding aniline derivatives were produced in 61–92% isolated yields. More impressively, a selective synthesis of cyclic amines such as pyrrolidines, piperidines and azepanes were conducted from levulinic acid, 1,5‐ and 1,6‐keto acids, respectively. The sequential procedure proceeded under both visible light irradiation and thermal conditions with 20 examples in isolated yields up to 69%.magnified image