bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbial Interventions to Control and Reduce Blood Pressure in Australia (MICRoBIA): rationale and design of a double-blinded randomised cross-over placebo controlled trial
Authors: Rhys-Jones Dakota , Climie Rachel E. , Gill Paul A. , Jama Hamdi A. , Head Geoffrey A. , Gibson Peter R. , Kaye David M. , Muir Jane G. , Marques Francine Z. 
Published: July 2021

Abstract
Background
Hypertension is a prevalent chronic disease worldwide that remains poorly controlled. Recent studies support the concept that the gut microbiota is involved in the development of hypertension and that dietary fibre intake may act through the gut microbiota to lower blood pressure (BP). Resistant starch is a type of prebiotic fibre which is metabolised by commensal bacteria in the colon to produce short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate. Previous work in pre-clinical models provides strong evidence that both prebiotic fibre as well as SCFAs (i.e. postbiotics) can prevent the development of hypertension. The aim of this clinical trial is to determine if acetylated and butyrylated modified resistant starch can decrease BP of hypertensive individuals via the modulation of the gut microbiota and release of high levels of SCFAs.

Methods
This is a phase IIa double-blinded, randomised, cross-over, placebo controlled trial. Participants are randomly allocated to receive either a diet containing 40 g/day of the modified resistant starch or placebo (corn starch or regular flour) for 3 weeks on each diet, with a 3-week washout period between the two diets. BP is measured in the office, at home, and using a 24-h ambulatory device. Arterial stiffness is measured using carotid-to-femoral pulse wave velocity. Our primary endpoint is a reduction in ambulatory daytime systolic BP. Secondary endpoints include changes to circulating cytokines, immune markers, and modulation to the gut microbiome.

Discussion
The findings of this study will provide the first evidence for the use of a combination of pre- and postbiotics to lower BP in humans. The results are expected at the end of 2021.

Trial registration
Australia and New Zealand Clinical Trial Registry ACTRN12619000916145. Registered on 1 July 2019.
Higher levels of anti-phosphorylcholine autoantibodies in early rheumatoid arthritis indicate lower risk of incident cardiovascular events
Authors: Ajeganova Sofia , Andersson Maria L. E. , Frostegård Johan , Hafström Ingiäld 
Published: July 2021

Abstract
Background
The increased risk of cardiovascular events (CVE) in rheumatoid arthritis (RA) is not fully explained by traditional risk factors. Immuno-inflammatory mechanisms and autoantibodies could be involved in the pathogenesis of atherosclerotic disease. It has been suggested that anti-phosphorylcholine antibodies (anti-PC) of the IgM subclass may have atheroprotective effects. Here, we aimed to investigate the association between levels of IgM anti-PC antibodies with CVE in patients with early RA.

Methods
The study population was derived from the BARFOT early RA cohort, recruited in 1994–1999. The outcome of incident CVE (AMI, angina pectoris, coronary intervention, ischemic stroke, TIA) was tracked through the Swedish Hospital Discharge and the National Cause of Death Registries. Sera collected at inclusion and the 2-year visit were analyzed with ELISA to determine levels of anti-PC IgM. The Kaplan-Meier estimates and Cox proportional hazards regression models were used to compare CV outcome in the groups categorized by baseline median level of IgM anti-PC.

Results
In all, 653 patients with early RA, 68% women, mean (SD) age 54.8 (14.7) years, DAS28 5.2 (1.3), 68% seropositive, and without prevalent CVD, were included. During the follow-up of mean 11.7 years, 141 incident CVE were recorded.
Baseline IgM anti-PC above median was associated with a reduction in risk of incident CVE in patients aged below 55 years at inclusion, HR 0.360 (95% CI, 0.142–0.916); in males, HR 0.558 (0.325–0.958); in patients with BMI above 30 kg/m2, HR 0.235 (0.065–0.842); and in those who did not achieve DAS28 remission at 1 year, HR 0.592 (0.379–0.924). The pattern of associations was confirmed in the models with AUC IgM anti-PC over 2 years.

Conclusion
Protective effects of higher levels of innate IgM anti-PC autoantibodies on CVE were detected in younger patients with RA and those at high risk of CVE: males, presence of obesity, and non-remission at 1 year.
Heterogeneity amongst GLP-1 RA cardiovascular outcome trials results: can definition of established cardiovascular disease be the missing link?
Authors: Melo Miguel , Gavina Cristina , Silva-Nunes José , Andrade Luís , Carvalho Davide 
Published: July 2021

AbstractAtherosclerotic cardiovascular diseases are the leading cause of adverse outcomes in patients with type 2 diabetes, and all new anti-diabetic agents are mandated to undergo cardiovascular outcome trials (CVOTs). Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are incretin mimetics that reduce blood glucose levels with a low associated risk of hypoglycaemia. CVOTs with different GLP-1 RAs yielded different results in terms of major cardiovascular composite outcome (MACE), with some trials showing superiority in the treatment arm, whereas other simply displayed non-inferiority. More importantly, the significance of each component of MACE varied between drugs. This begs the question of whether these differences are due to dissimilarities between drugs or other factors, namely trial design, are at the root of these differences. We analyse the trial designs for all CVOTs with GLP-1 RAs and highlight important differences between them, namely in terms of definition of established cardiovascular disease, and discuss how these differences might explain the disparate results of the trials and preclude direct comparisons between them. We conclude that a fair comparison between GLP-1 RA CVOTs would involve post-hoc analysis re-grouping the patients into different cardiovascular risk categories based upon their baseline clinical parameters, in order to even out the criteria used to classify patients.
Hemosiderin deposition evaluation in hemophilic ankle joints: association between US finding and gradient-recalled echo MR imaging sequence
Authors: Prasetyo Marcel , Mongan Ariel Elisa , Chozie Novie Amelia , Prihartono Joedo , Setiawan Stefanus Imanuel 
Published: July 2021

Abstract
Background
Repeated bleeding in hemophilic arthropathy (HA) may result in severe degenerative changes and joint destruction. The gradient-recalled echo (GRE) sequence MR is proved to be the best method to detect hemosiderin deposition. However, MR is not widely available in developing countries, including Indonesia. Some studies have proposed ultrasonography (US) as an alternative tool in evaluating hemophilic joint. However, there is still some disagreement on the ability of US to detect hemosiderin deposition.

Objective
To evaluate the association between US and GRE-sequence MR imaging in detecting hemosiderin deposition in hemophilic ankle joint.

Material and methods
A total of 102 sites from 17 ankle joints of 11 boys with severe hemophilia A underwent US examination using a high-frequency linear array transducer. GRE-sequence MR examination was performed in sagittal view consistent with the sites scanned by US. Both examinations were performed on the same day, but MR interpretation was performed blindly at different times. The association between US and GRE-sequences in detecting hemosiderin deposition was analyzed using McNemar’s test.

Results
Statistical analysis showed a significant association (p value < 0.001) between US and GRE MR in detecting hemosiderin deposition, but the association is weak (R = 0.26). Sensitivity and specificity of US for detecting hemosiderin deposition were 46.84% (95%CI: 35.51–58.40) and 95.65% (95%CI: 78.05–99.89), respectively, with positive predictive value 97.37% (95%CI: 84.29–99.61), negative predictive value 34.38% (95%CI: 29.50–39.60) and accuracy 57.84% (95%CI: 47.66–67.56).

Conclusion
There was a weak association between US and GRE-sequences in detecting hemosiderin deposition of hemophilic ankle joint. ​​
Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19?
Authors: da Silva Kátia Nunes , Gobatto André Luiz Nunes , Costa-Ferro Zaquer Suzana Munhoz , Cavalcante Bruno Raphael Ribeiro , Caria Alex Cleber Improta , de Aragão França Luciana Souza , Nonaka Carolina Kymie Vasques , de Macêdo Lima Fernanda , Lopes-Pacheco Miquéias , Rocco Patricia Rieken Macêdo , de Freitas Souza Bruno Solano 
Published: July 2021

AbstractThe COVID-19 pandemic, caused by the rapid global spread of the novel coronavirus (SARS-CoV-2), has caused healthcare systems to collapse and led to hundreds of thousands of deaths. The clinical spectrum of COVID-19 is not only limited to local pneumonia but also represents multiple organ involvement, with potential for systemic complications. One year after the pandemic, pathophysiological knowledge has evolved, and many therapeutic advances have occurred, but mortality rates are still elevated in severe/critical COVID-19 cases. Mesenchymal stromal cells (MSCs) can exert immunomodulatory, antiviral, and pro-regenerative paracrine/endocrine actions and are therefore promising candidates for MSC-based therapies. In this review, we discuss the rationale for MSC-based therapies based on currently available preclinical and clinical evidence of safety, potential efficacy, and mechanisms of action. Finally, we present a critical analysis of the risks, limitations, challenges, and opportunities that place MSC-based products as a therapeutic strategy that may complement the current arsenal against COVID-19 and reduce the pandemic’s unmet medical needs.
Implant-prosthetic rehabilitation of patients with severe horizontal bone deficit on mini-implants with two-piece design—retrospective analysis after a mean follow-up of 5 years
Authors: Wimmer Lukas , Petrakakis Pantelis , El-Mahdy Karim , Herrmann Surian , Nolte Dirk 
Published: July 2021

Abstract
Background
As a consequence of tooth loss due to trauma or extraction, a reduced alveolar crest volume limits the deployment of standard implants in certain patient cases. For this reason, minimal-invasive treatment with mini-dental implants (MDI) might be an option to allow implant treatment even in cases with severe horizontal bone loss without augmentation measures. The aim of this retrospective cohort study was to investigate clinical and radiological implant, as well as patient-related parameters after treatment with MDI.

Results
Clinical and radiological records of 19 female (82.6%) and 4 male patients (17.4%) (N = 23), who received 52 mini-dental implants with a two-piece design in a single surgical center between November 2011 and October 2018, were retrospectively analyzed. Implants were submitted to conventional loading on different types of screwed superstructures. Crestal bone loss was measured on standardized periapical radiographs. Patient-related outcome parameters (PROMs) were recorded during follow-up period. Mean clinical and radiological follow-up was 69.6 months (5.8 years) and 51.6 months (4.3 years), respectively. Three implants were lost in two patients, leading to an implant survival rate of 94.2%. Mean radiological crestal bone loss was 1.6 mm. Both amount of peri-implant recession and crestal bone loss were significantly correlated (r = 0.65; p < 0.001). Likewise, a significant correlation was observed between deeper probing depths and increased peri-implant bone loss (r = 0.41; p = 0.012). Alveolar ridges with a reduced alveolar crest width were significantly correlated with higher peri-implant bone loss as well (r = − 0.33; p = 0.011). No prosthetic complications were reported during follow-up. Extent of midfacial recession and papilla height loss had a significant negative impact on most of the PROMs.

Conclusions
Treatment with MDI seems to be a successful alternative treatment option, especially for elderly patients with reduced crest width at implant sites. Due to the good clinical results and high survival and success rates, this treatment option was associated with high patient satisfaction. Despite the promising results, particular consideration should be given to appropriate treatment planning in these patients due to the strong correlation between peri-implant soft-tissue parameters, crestal bone loss, and reduced alveolar crest width.
Hybrid inner-outer algorithm for solving real-world mechanical optimization problems
Authors: Abouhabaga Omnia Osman Fadel , Gadallah Mohamed Hassan , Kouta Hanan Kamel , Zaghloul Mohamed Abass 
Published: July 2021

AbstractIn the real world, the problems mostly are complex; more precisely, the problems generally are nonlinear or large scale other than if it was mandatory to resolve it under certain constraints, and that is common in engineering design problems. Therefore, the complexity of problem plays a critical role in determining the computational time and cost. Accordingly, a novel algorithm called inner-outer array is proposed in this paper. It depends on the design of parameters and then tolerance design as one of design of experiment stages. In this work, the inner-outer algorithm is used to solve real-world optimization problems to choose the preferable feasible regions of the entire search domain. Numerical results are documented and compared based on four well-known constrained mechanical engineering issues. It can be concluded that the performance of inner-outer algorithm is good to optimize constrained engineering problems, but it still needs some enhancements in the future work.
Incidence and outcomes of eating disorders during the COVID-19 pandemic
Authors: Taquet Maxime , Geddes John R. , Luciano Sierra , Harrison Paul J. 
Published: July 2021

SummaryThere are concerns that eating disorders have become commoner during the coronavirus disease 2019 (COVID-19) pandemic. Using the electronic health records of 5.2 million people aged under 30, mostly in the USA, we show that the diagnostic incidence was 15.3% higher in 2020 overall compared with previous years (relative risk 1.15, 95% CI 1.12−1.19). The relative risk increased steadily from March 2020 onwards, exceeding 1.5 by the end of the year. The increase occurred solely in females, and primarily related to teenagers and anorexia nervosa. A higher proportion of patients with eating disorders in 2020 had suicidal ideation (hazard ratio HR = 1.30, 1.16−1.47) or attempted suicide (HR = 1.69, 1.21−2.35).
Energetic cost of Hamiltonian quantum gates
Authors: Deffner Sebastian 
Published: July 2021

Abstract
Landauer's principle laid the main foundation for the development of modern thermodynamics of information. However, in its original inception the principle relies on semiformal arguments and dissipative dynamics. Hence, if and how Landauer's principle applies to unitary quantum computing is less than obvious. Here, we prove an inequality bounding the change of Shannon information encoded in the logical quantum states by quantifying the energetic cost of Hamiltonian gate operations. The utility of this bound is demonstrated by outlining how it can be applied to identify energetically optimal quantum gates in theory and experiment. The analysis is concluded by discussing the energetic cost of quantum error correcting codes with non-interacting qubits, such as Shor's code.
Regional femoral bone blood flow rates in laying and non-laying chickens estimated with fluorescent microspheres
Authors: Hu Qiaohui , Nelson Thomas J. , Seymour Roger S. 
Published: July 2021

ABSTRACT
The metabolic rate of vertebrate bone tissue is related to bone growth, repair and homeostasis, which are all dependent on life stage. Bone metabolic rate is difficult to measure directly, but absolute blood flow rate () should reflect local tissue oxygen requirements. A recent ‘foramen technique’ has derived an index of blood flow rate () by measuring nutrient foramen sizes of long bones. is assumed to be proportional to ; however, the assumption has never been tested. This study used fluorescent microsphere infusion to measure femoral bone in anaesthetized non-laying hens, laying hens and roosters. Mean mass-specific cardiac output was 338±38 ml min−1 kg−1, and the two femora received 0.63±0.10% of this. Laying hens had higher wet bone mass-specific to femora (0.23±0.09 ml min−1 g−1) than the non-laying hens (0.12±0.06 ml min−1 g−1) and roosters (0.14±0.04 ml min−1 g−1), presumably associated with higher bone calcium mobilization during eggshell production. Estimated metabolic rate of femoral bone was 0.019 ml O2 min−1 g−1. Femoral increased significantly with body mass, but was not correlated with nutrient foramen radius (r), probably because of a narrow range in foramen radius. Over all 18 chickens, femoral shaft was 1.07±0.30 ml min−1 mm−1. Mean in chickens was significantly higher than predicted by an allometric relationship for adult cursorial bird species, possibly because the birds were still growing.
Surfactant-Free Aqueous Fabrication of Macroporous Silicone Monoliths for Flexible Thermal Insulation
Authors: Hayase Gen 
Published: July 2021

Abstract
Hydrophobic silicone macroporous materials prepared in an aqueous solution by the sol–gel method have been considered for various applications such as separation media, heat insulators, and liquid nitrogen adsorbents. In the conventional preparation process, surfactants are used to suppress phase separation to obtain a uniform bulk material. However, a large amount of solvent and time is required to remove them before drying, which hinders industrial-scale synthesis. By copolymerizing tetra-, tri-, and bifunctional organosilicon alkoxides in an aqueous acetic acid–urea solution, flexible macroporous silicone monoliths were successfully obtained. The marshmallow-like monoliths recovered their original shape even after 80% uniaxial compression and significant bending and water repellency. The thermal conductivity of those materials was ∼0.035 W m−1 K−1 and did not increase even under 60% uniaxial compression. This characteristic property can be used for thermal insulation on surfaces with various shapes and in confined spaces under harsh conditions.
Robust Gels Composed of Self-Assembled Cello-oligosaccharide Networks
Authors: Hata Yuuki , Serizawa Takeshi 
Published: July 2021

Abstract
Assembled molecular gels exhibit dynamic properties and have been developed as functional soft materials with self-healing ability, stimuli responsiveness, and other such properties. Nevertheless, dynamicity is not essential to molecular assemblies. We created static and robust hydrogels composed of self-assembled cello-oligosaccharide networks. In fact, the novel gels are solvent-exchangeable from water even to nonpolar organic solvents, reflecting extremely low stimuli responsiveness. This Account summarizes our recent research progress on cello-oligosaccharide gels, from their production to applications that exploit the unique properties of these crystalline oligosaccharide assemblies. Our findings suggest that statically assembled molecular gels have unconventional applications.
The $^{135}$Cs(n,$\gamma$) cross section at 30 and 500 keV
Authors: Patronis N. , Assimakopoulos P. A. , Dababneh S. , Heil M. , Kaeppeler F. , Karamanis D. , Koehler P. E. , Plag R. 
Published: July 2021

The neutron capture cross section of the unstable isotope $^{135}$Cs was measured relative to that of gold by means of the activation method. The sample was produced by ion implantation in a high resolution mass separator and irradiated with quasi-monoenergetic neutrons at 30 keV and 500 keV, using the $^{7}$Li(p,n)$^{7}$Be reaction. After the irradiations at the above energies, one more irradiation with thermal neutrons was used for defining the sample mass and for measuring the half-life of $^{136}$Cs. The neutron capture cross section was determined as 164 $\pm$ 10 mbarn and 34.8 $\pm$ 3.0 mbarn at 30 keV and 500 keV, respectively, and were used to normalize the theoretically derived cross section shape.
A pilot study of risk-stratified cervical cancer screening
Authors: Wang Jiangrong , Elfström K. Miriam , Borgfeldt Christer , Dillner Joakim 
Published: July 2021

Background: Cervical screening programs target entire populations, although it is well established that cervical cancer risks can vary >100-fold based, in particular, on the woman’s screening history. Since cervical screening switched to Human Papillomavirus (HPV) testing as the primary screening method, the risk differences are even larger as different HPV types may vary in associated cancer risk by 100 times. Furthermore, HPV infections with the most oncogenic types are declining dramatically because of HPV vaccination programs. Tailoring screening intensity based on the known cancer risk of the individual (risk-stratified screening) therefore has great potential to increase both the sensitivity and specificity. Within Horizon 2020 a major project for RIsk-stratified Screening for Cervical Cancer (RISCC) has therefore been launched. We performed a pilot study of risk-stratified screening to evaluate feasibility and acceptability of offering vaginal HPV self-sampling tests to women with a higher risk of cervical cancer. Methods: We identified resident women who had had either i) atypical glandular cells in screening tests during the past six years (risk >150/100,000 woman-years) or ii) abnormal screening findings above the age of 50, but without sufficient follow-up (risk >65/100,000). The women were invited, either by short message service (SMS) or physical letters, to order an HPV self-sampling kit via the study web-platform. The returned self-collected samples were tested for HPV. If positive, women were invited for clinical follow-up. Results: Among 920 targeted women, 191 (21%) placed an order and 163 (18%) returned a self-collected sample. Among all tested samples, 19 (12%) were positive for hrHPV and 18 of these women attended clinical follow-up. Conclusions: We found that SMS invitations to high-risk women are feasible and result in substantial requests for kits and submission of samples. Future work will focus on improving the efficiency of the procedure and further increasing attendance.