bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface Passivation Treatment to Improve Performance and Stability of Solution‐Processed Metal Oxide Transistors for Hybrid Complementary Circuits on Polymer Substrates
Authors: Kang Moon Hyo , Armitage John , Andaji‐Garmaroudi Zahra , Sirringhaus Henning 
Published: October 2021

AbstractHybrid integration of n‐type oxide with p‐type polymer transistors is an attractive approach for realizing high performance complementary circuits on flexible substrates. However, the stability of solution‐processed oxide transistors is limiting the lifetime and reliability of such circuits. Oxygen vacancies are the main defect degrading metal oxide transistor performance when ambient oxygen adsorbs onto metal oxide films. Here, an effective surface passivation treatment based on negative oxygen ion exposure combined with UV light is demonstrated, that is able to significantly reduce surface oxygen vacancy concentration and improve the field effect mobility to values up to 41 cm2 V−1 s−1 with high on–off current ratio of 108. The treatment also reduces the threshold voltage shift after 2 days in air from 5 to 0.07 V. The improved stability of the oxide transistors also improves the lifetime of hybrid complementary circuits and stable operation of complementary, analog amplifiers is confirmed for 60 days in air. The suggested approach is facile and can be widely applicable for flexible electronics using low‐temperature solution‐processed metal oxide semiconductors.
Tunable Proton Conductivity and Color in a Nonporous Coordination Polymer via Lattice Accommodation to Small Molecules
Authors: Develioglu Aysegul , Resines‐Urien Esther , Poloni Roberta , Martín‐Pérez Lucía , Costa Jose Sanchez , Burzurí Enrique 
Published: October 2021

AbstractNonporous coordination polymers (npCPs) able to accommodate molecules through internal lattice reorganization are uncommon materials with applications in sensing and selective gas adsorption. Proton conduction, extensively studied in the analogue metal‐organic frameworks under high‐humidity conditions, is however largely unexplored in spite of the opportunities provided by the particular sensitivity of npCPs to lattice perturbations. Here, AC admittance spectroscopy is used to unveil the mechanism behind charge transport in the nonporous 1·2CH3CN. The conductance in the crystals is found to be of protonic origin. A vehicle mechanism is triggered by the dynamics of the weakly coupled acetonitrile molecules in the lattice that can be maintained by a combination of thermal cycles, even at low humidity levels. An analogue 1·pyrrole npCP is formed by in situ exchange of these weakly bound acetonitrile molecules by pyrrole. The color and conduction properties are determined by the molecules weakly bonded in the lattice. This is the first example of acetonitrile‐mediated proton transport in an npCP showing distinct optical response to different molecules. These findings open the door to the design of switchable protonic conductors and capacitive sensors working at low humidity levels and with selectivity to different molecules.
The hypoxia adaptation of small mammals to plateau and underground burrow conditions
Authors: Li Mengke , Pan Dan , Sun Hong , Zhang Lei , Cheng Han , Shao Tian , Wang Zhenlong 
Published: October 2021

AbstractOxygen is one of the important substances for the survival of most life systems on the earth, and plateau and underground burrow systems are two typical hypoxic environments. Small mammals living in hypoxic environments have evolved different adaptation strategies, which include increased oxygen delivery, metabolic regulation of physiological responses and other physiological responses that change tissue oxygen utilization. Multi‐omics predictions have also shown that these animals have evolved different adaptations to extreme environments. In particular, vascular endothelial growth factor (VEGF) and erythropoietin (EPO), which have specific functions in the control of O2delivery, have evolved adaptively in small mammals in hypoxic environments. Naked mole‐rats and blind mole‐rats are typical hypoxic model animals as they have some resistance to cancer. This review primarily summarizes the main living environment of hypoxia tolerant small mammals, as well as the changes of phenotype, physiochemical characteristics and gene expression mode of their long‐term living in hypoxia environment.
Synthesis and wound healing performance of new water‐soluble chitosan derivatives
Authors: Shahzadi Lubna , Jamal Arshad , Hajivand Pegah , Mahmood Nasir , Anwar Chaudhry Aqif , ur Rehman Ihtesham , Yar Muhammad 
Published: October 2021

AbstractIn present work, an efficient method for the preparation of water‐soluble chitosan (CS) is reported. It is based on simple synthetic method, which is easy to handle and delivered good water solubility. This article describes the effect of various factors such as the concentration of reactants and the amount of solvents on the reactions' outcome as well as cytocompatibility of the resulting water‐soluble CS derivatives. CS derivatives with different ratios of polyethyleneimine (PEI) (80:20 (CP1), 90:20 (CP2), 95:5 (CP3), 99:1 (CP4), and 99.6:0.4 [CP5]), at optimized conditions (50 g of CS, 1 L of 0.5 M acetic acid solution at 80°C for 24 h) were synthesized. It was noted that the amount of PEI was critical for the cytocompatibility, decreasing the amount of PEI led to increasing the cytocompatibility of the obtained water soluble CS derivatives. To show the biomedical and drug delivery applications of the newly synthesized CS derivative, this was used to prepare membranes by freeze‐drying and was loaded with thyroxine, respectively. The angiogenic potential of the thyroxine loaded membranes was tested in chorio allantoic membrane assay, which showed good level of neovascularization. For wound healing studies full thickness wounds rat model was used and thyroxine loaded hydrogels showed complete wound healing at day 23.
Synthesis and properties of neat, hybrid, and copolymeric polyamide 12 microparticles and composites on their basis
Authors: Vasileva Dencheva Nadya , Braz Joana Filipa Barros , Denchev Zlatan Zlatev 
Published: October 2021

AbstractNeat and hybrid polyamide 12 (PA12) based powders are important raw materials for additive manufacturing. This study describes a facile method for the synthesis of pure, hybrid and copolymeric microparticulate materials based on one‐pot activated anionic ring‐opening polymerization (AAROP) of laurolactam in solution. The results reveal the possibility to obtain in good yields, for reaction times of 2 h and temperatures of up to 110°C neat and hybrid PA12 microparticles (MP) carrying metal or carbon fillers. Copolymeric PA12/PA6 MP can also be successfully prepared. All MP materials are analyzed by spectral, microscopy, thermal, and synchrotron X‐ray scattering methods in order to clarify their morphology, chemical and crystalline structure, melting and degradation behavior. The melting temperature of the PA12 MP is lower than of the commercial PA12, the presence of metal particles or copolymerization with PA6 additionally decrease it well below 170°C. The composites prepared by compression molding of PA12 MP display elastic modulus of up to 1.49 GPa, the stresses at yield and break reaching 50 and 69 MPa, respectively. It is concluded that the neat, hybrid, and copolymeric pulverulent materials obtained via microencapsulation by AAROP in solution may be useful in additive manufacturing processing.
Cellulose nanocrystals supported—PolyHIPE foams for low‐temperature latent heat storage applications
Authors: Türkoğlu Zehra , Mert Hatice Hande , Mert Emine Hilal , Ocak Hale , Mert Mehmet Selçuk 
Published: October 2021

AbstractParaffin‐based shape‐stabilized composite phase change materials (PCM) containing surface modified cellulose nanocrystals (CNCs) for thermal energy storage applications were prepared. In this respect, a three‐step experimental procedure consisting nanoparticle modification, macroporous foam synthesis, and composite PCM preparation was implemented. While CNCs were modified via freeze‐templating, high internal phase emulsion (HIPE) templating was used for the synthesis of polymeric foams ‐ known as polyHIPEs. Meanwhile a simple method was applied to impregnate n‐hexadecane (HD), which is a paraffin‐based PCM within the polyHIPE foam matrix. It was demonstrated that surface modified CNCs can be efficiently used to prepare polyHIPE foams with improved properties. It was also shown that the impregnation of HD into the ‐polyHIPE foam matrix supported by CTAB‐CNCs can be achieved with an incorporation rate of up to 55.7%. Moreover, the phase transition temperature and thermal energy storage capacity of the obtained composite PCM was determined as 22.7°C and 117 J/g, respectively.
First Description of Late‐Onset Autoinflammatory Disease Due to Somatic NLRC4 Mosaicism
Authors: Ionescu Daniela , Peñín‐Franch Alejandro , Mensa‐Vilaró Anna , Castillo Paola , Hurtado‐Navarro Laura , Molina‐López Cristina , Romero‐Chala Silvia , Plaza Susana , Fabregat Virginia , Buján Segundo , Marques Joana , Casals Ferran , Yagüe Jordi , Oliva Baldomero , Fernández‐Pereira Luis Miguel , Pelegrín Pablo , Aróstegui Juan I. 
Published: October 2021

ObjectiveAutoinflammatory diseases are inherited disorders of innate immunity that usually start during childhood. However, several recent reports have described an increasing number of patients with autoinflammatory disease starting in adulthood. This study was undertaken to investigate the underlying cause of a case of late‐onset uncharacterized autoinflammatory disease.MethodsGenetics studies were performed using Sanger sequencing and next‐generation sequencing (NGS) methods. In silico, in vitro, and ex vivo analyses were performed to determine the functional consequences of the detected variant.ResultsWe studied a 57‐year‐old woman who at the age of 47 years began to have recurrent episodes of fever, myalgias, arthralgias, diffuse abdominal pain, diarrhea, adenopathies, and systemic inflammation, which were relatively well controlled with anti–interleukin‐1 (anti‐IL‐1) drugs. NGS analyses did not detect germline variants in any of the known autoinflammatory disease–associated genes, but they identified the p.Ser171Phe NLRC4 variant in unfractionated blood, with an allele fraction (2–4%) compatible with gene mosaicism. Structural modeling analyses suggested that this missense variant might favor the open, active conformation of the NLRC4 protein, and in vitro and ex vivo analyses confirmed its propensity to oligomerize and activate the NLRC4 inflammasome, with subsequent overproduction of IL‐18.ConclusionOur findings indicate that the postzygotic p.Ser171Phe NLRC4 variant is a plausible cause of the disease in the enrolled patient. Functional and structural studies clearly support, for the first time, its gain‐of‐function behavior, consistent with previously reported NLRC4 pathogenic variants. These novel findings should be considered in the diagnostic evaluation of patients with adult‐onset uncharacterized autoinflammatory disease.
Fairness in digital sharing legal professional attitudes toward digital piracy and digital commons
Authors: Ciesielska Malgorzata , Jemielniak Dariusz 
Published: October 2021

AbstractContrary to a popular belief of lawyers having the most strict perception of law, law professionals actually strongly skew toward more favorable views of digital sharing. According to our qualitative study, relying on in‐depth interviews with 50 Harvard lawyers, digital piracy is quite acceptable. It is considered fair, especially among friends and for noncommercial purposes. We argue that this not only can indicate that the existing law is becoming outdated because of its inability to be enforced, but also that ethically it is not corresponding to what is considered fair, good service, or being societally beneficial. The common perception of relying on a fixed price for digital content is eroding. We show that on the verges of business, society, and law, there is a potential for the new paradigm of digital commons to emerge.
Methods for a feminist technoscience of information practice: Design justice and speculative futurities
Authors: Floegel Diana , Costello Kaitlin L. 
Published: October 2021

AbstractThis article builds on the argument that feminist technoscience will advance information practice scholarship beyond its current limitations. These limitations reflect neoliberalism in the field of information science and include a reliance on extractive logics in theories and models, monological individualism, binaries constructed between people and technologies, and techno‐solutionism. Here, we address the question: what does it look like to apply technofeminism to the study of information practice at methodological and methods levels? We first outline our metatheoretical conception of feminist technoscience, which embraces intersectionality and assemblage theory in order to move past white and colonialist logics embedded in cyborg theory. We next offer design justice as a methodological framework and movement that provides a necessary overhaul of the neoliberal ways that information science approaches scholarship, particularly in terms of participatory research. We suggest that speculative futurities provide a promising method for advancing technofeminism in information practice research because they explicitly reject neoliberalism and its techno‐solutionist bent. Overall, a feminist technoscience of information practice offers directions for our field that are rooted in liberatory epistemologies. We emphasize that in order to achieve liberation, a major overhaul in how our discipline approaches arrangements of information, people, and technologies is sorely needed.
Self‐Assembly Methods for Recently Reported Discrete Supramolecular Structures Based on Terpyridine
Authors: Shi Junjuan , Wang Ming 
Published: October 2021

AbstractIn this Review, self‐assembly methods of discrete metallo‐supramolecules based on 2,2′ : 6′,2′′‐terpyridine (tpy) are comprehensively summarized. With the development of self‐assembly, strategies for discrete 2D and 3D supramolecular architectures have boomed, including the geometry‐directed method, template‐driven method, and stepwise method. Ligand geometry‐directed method mainly depends on the geometry of ligands (i. e., angle, geometric strain, and rigidity), and it is suitable for dual‐component systems, while the template‐driven method can guide the self‐assembly of predesigned supramolecules by the introduction of specific templates. Meanwhile, stepwise method, breaking the inherent self‐sorting of ligands and reducing the probability of mismatch, is suitable for multicomponent systems to yield predesigned supramolecules. This review focuses on self‐assembly methods and aims to provide a guideline for constructing supramolecular architectures using a suitable approach.
Protective mechanism of FoxO1 against early brain injury after subarachnoid hemorrhage by regulating autophagy
Authors: Hao Haitao , Bai Yahui , Liu Yu , Liang Junxin , Guo Shichao 
Published: October 2021

AbstractIntroductionEarly brain injury (EBI) plays a key role in the devastating outcomes after subarachnoid hemorrhage (SAH). Autophagy and apoptosis may share a common molecular inducer that regulates the process of cell death. FoxO1, as a key regulator of neuronal autophagy which is involved in apoptosis, has not been reported in SAH rats. This work was to investigate the protective and anti‐inflammatory effects of FoxO1 on EBI after SAH by regulating autophagy.MethodsIn this study, we constructed the SAH model. In experiment I, low dose (50 μl of 1 × 108 IU/ml) or high dose (50 μl of 1 × 1010 IU/ml) of FoxO1 gene overexpressed adenovirus vector was injected into the lateral ventricle of rats before SAH. In experiment II, we reported the effect of FoxO1 overexpress on nerve function recovery, oedema, BBB leakage, neuronal death in rats after SAH through autophagy regulation. Post‐SAH evaluation included neurological function score, brain water content, evans blue exosmosis, pathological changes, inflammatory response and apoptosis.ResultsThe experiment I showed that either low or high dose of ad‐FoxO1 could significantly improve nerve function, reduce cerebral water content and reduce blood‐brain barrier (BBB) destruction in rats, indicating that ad‐FoxO1 had a protective effect on brain injury in rats EBI after SAH. In addition, ad‐FoxO1 promoted autophagy in rat hippocampal tissue, as evidenced by accumulation of LC3II/I and Beclin‐1 and degradation of p62. Furthermore, ad‐FoxO1 inhibited the inflammatory response and apoptosis of rat hippocampal neurons after SAH. The experiment II showed that both ad‐FoxO1 and rapamycin attenuated the injury of nerve function in rats after SAH, and this synergistic effect further reduced cerebral edema and evansblue extravasation, decreased hippocampus neuronal cell apoptosis, and declined inflammatory response. However, this was contrary to the results of chloroquine. These findings suggested that FoxO1 regulated the neural function of EBI after SAH through the autophagy pathway.ConclusionsThe findings in this study was beneficial for identifying the novel therapeutic target for the treatment of SAH.
Unravelling the design process of business models from linear to circular: An empirical investigation
Authors: Franzò Simone , Urbinati Andrea , Chiaroni Davide , Chiesa Vittorio 
Published: October 2021

AbstractIn the last years, circular economy has represented one of the most‐debated topics in management research. Although the understanding of this industrial paradigm has significantly improved over the last decade, a number of important research questions still remain unanswered. Among them, the design process of business model through which established firms evolve from being linear to circular deserves further investigation. Existing research still falls short to investigate how companies design the dimensions of value creation, value transfer, and value capture of their business models to launch circular products into the market. By leveraging a multiple case study analysis of four companies in the paper and beverage industries that have launched six circular products, the paper examines the process that these companies have followed to face the transition toward a circular business model. The paper contributes to the research field in the intersection between new product development and circular business models, by showing that the process toward a circular business model occurs along three major phases, that is, idea generation, product development, and commercialization. In each phase, companies implement peculiar managerial practices for launching circular products into the market, which typically address all the dimensions of the business model and follows a recurrent path over time.
Rational, emotional, or both? Subcomponents of psychopathy predict opposing moral decisions
Authors: Hauser Nicole Claire , Neumann Craig S. , Marshall Julia , Mokros Andreas 
Published: October 2021

AbstractRecent research has documented a small but significant correlation between psychopathic capacities and utilitarian moral judgment, although the findings are generally inconsistent and unclear. We propose that one way to make sense of mixed findings is to consider variation in perspective‐taking capacities of psychopathic individuals. With this in mind, we had criminal offenders (n = 60), who varied in their psychopathy levels according to the Psychopathy Checklist‐Revised (PCL‐R), respond to common sacrificial moral dilemmas (e.g., trolley dilemmas) under different conditions. In a baseline condition, participants simply responded to the sacrificial moral dilemmas as is typically done in previous research. In an “emotion‐salient” condition, participants had to reason about the emotions of another person after solving moral dilemmas (deliberative processing). In the “emotion‐ambiguous” condition, participants saw images of people in distress, after solving moral dilemmas, but did not have to explicitly reason about such emotions (spontaneous processing). The four PCL‐R facets predicted distinct interference effects depending on spontaneous versus deliberative processing of hypothetical victim's emotions. The findings suggest that the use of a multi‐faceted approach to account for cognitive and moral correlates of psychopathy may help address previously mixed results. Implications and future directions for theory and research are discussed.
Copy number variation analysis of m6A regulators identified METTL3 as a prognostic and immune‐related biomarker in bladder cancer
Authors: Wang Xiaoshuai , Yu Jingwei , Chen Jinbao , Hou Yingdong , Du Zefeng , Huang Haoyang , Tang Siqi , Han Yueyin , Ding Changhai , Xue Zhicheng 
Published: October 2021

AbstractPurposeGrowing evidence has demonstrated an indispensable role for N6‐methyladenosine (m6A) in human diseases, but the copy number variations (CNVs) of m6A regulatory genes in bladder cancer (BLCA) remains largely unknown.MethodsWe investigated the CNVs on all known m6A regulatory genes using the Cancer Genome Atlas (TCGA) database. The association between CNV events and clinicopathological as well as molecular characteristics of BLCA patients were explored. Gene set enrichment analysis (GSEA) was implemented to reveal relative cellular processes. Association between m6A regulatory genes and immune infiltrates was analyzed by The Tumor Immune Estimation Resource (TIMER) database.ResultsCNV events of m6A regulatory genes were frequently observed in BLCA. CNVs of METTL3, METTL14, and METTL16 correlated with molecular characteristics of BLCA patients including TP53 mutation. CNVs of METTL3 associated with the overall survival (OS) of BLCA patients. METTL3 was also associated with several cancer‐related cellular processes, including mitotic spindle assembly, G2/M checkpoint, and E2F targets signaling pathway. Besides, the CNVs of m6A regulatory genes were correlated with specific kinds of immune infiltrates.ConclusionsThere are significant correlations between m6A regulatory genes with CNVs and clinicopathological characteristics. METTL3 with CNVs were associated with the immune infiltrates and performed as a prognostic marker in BLCA.