bluuebunny/crossref_metadata_2025_split huggingface dataset:
A state-space approach to understand responses of organisms, populations and communities to multiple environmental drivers
Authors: Giménez Luis , Chatterjee Adreeja , Torres Gabriela 
Published: September 2021

AbstractUnderstanding the response of biotic systems to multiple environmental drivers is one of the major concerns in ecology. The most common approach in multiple driver research includes the classification of interactive responses into categories (antagonistic, synergistic). However, there are situations where the use of classification schemes limits our understanding or cannot be applied. Here, we introduce and explore an approach that allows us to better appreciate variability in responses to multiple drivers. We then apply it to a case, comparing effects of heatwaves on performance of a cold-adapted species and a warm-adapted competitor. The heatwaves had a negative effect on the native (but not on the exotic) species and the approach highlighted that the exotic species was less responsive to multivariate environmental variation than the native species. Overall, we show how the proposed approach can enhance our understanding of variation in responses due to different driver intensities, species, genotypes, ontogeny, life-phases or among spatial scales at any level of biological organization.
Multi-angle pulse shape detection of scattered light in flow cytometry for label-free cell cycle classification
Authors: Kage Daniel , Heinrich Kerstin , Volkmann Konrad v. , Kirsch Jenny , Feher Kristen , Giesecke-Thiel Claudia , Kaiser Toralf 
Published: September 2021

AbstractFlow cytometers are robust and ubiquitous tools of biomedical research, as they enable high-throughput fluorescence-based multi-parametric analysis and sorting of single cells. However, analysis is often constrained by the availability of detection reagents or functional changes of cells caused by fluorescent staining. Here, we introduce MAPS-FC (multi-angle pulse shape flow cytometry), an approach that measures angle- and time-resolved scattered light for high-throughput cell characterization to circumvent the constraints of conventional flow cytometry. In order to derive cell-specific properties from the acquired pulse shapes, we developed a data analysis procedure based on wavelet transform and k-means clustering. We analyzed cell cycle stages of Jurkat and HEK293 cells by MAPS-FC and were able to assign cells to the G1, S, and G2/M phases without the need for fluorescent labeling. The results were validated by DNA staining and by sorting and re-analysis of isolated G1, S, and G2/M populations. Our results demonstrate that MAPS-FC can be used to determine cell properties that are otherwise only accessible by invasive labeling. This approach is technically compatible with conventional flow cytometers and paves the way for label-free cell sorting.
Deep-coverage spatiotemporal proteome of the picoeukaryote Ostreococcus tauri reveals differential effects of environmental and endogenous 24-hour rhythms
Authors: Kay Holly , Grünewald Ellen , Feord Helen K. , Gil Sergio , Peak-Chew Sew Y. , Stangherlin Alessandra , O’Neill John S. , van Ooijen Gerben 
Published: September 2021

AbstractThe cellular landscape changes dramatically over the course of a 24 h day. The proteome responds directly to daily environmental cycles and is additionally regulated by the circadian clock. To quantify the relative contribution of diurnal versus circadian regulation, we mapped proteome dynamics under light:dark cycles compared with constant light. Using Ostreococcus tauri, a prototypical eukaryotic cell, we achieved 85% coverage, which allowed an unprecedented insight into the identity of proteins that facilitate rhythmic cellular functions. The overlap between diurnally- and circadian-regulated proteins was modest and these proteins exhibited different phases of oscillation between the two conditions. Transcript oscillations were generally poorly predictive of protein oscillations, in which a far lower relative amplitude was observed. We observed coordination between the rhythmic regulation of organelle-encoded proteins with the nuclear-encoded proteins that are targeted to organelles. Rhythmic transmembrane proteins showed a different phase distribution compared with rhythmic soluble proteins, indicating the existence of a circadian regulatory process specific to the biogenesis and/or degradation of membrane proteins. Our observations argue that the cellular spatiotemporal proteome is shaped by a complex interaction between intrinsic and extrinsic regulatory factors through rhythmic regulation at the transcriptional as well as post-transcriptional, translational, and post-translational levels.
Non-classical photonic spin texture of quantum structured light
Authors: Yang Li-Ping , Jacob Zubin 
Published: September 2021

AbstractClassical structured light with controlled polarization and orbital angular momentum (OAM) of electromagnetic waves has varied applications in optical trapping, bio-sensing, optical communications and quantum simulations. However, quantum noise and photon statistics of three-dimensional photonic angular momentum are relatively less explored. Here, we develop a quantum framework and put forth the concept of quantum structured light for space-time wavepackets at the single-photon level. Our work deals with three-dimensional angular momentum observables for twisted quantum pulses beyond scalar-field theory as well as the paraxial approximation. We show that the spin density generates modulated helical texture and exhibits distinct photon statistics for Fock-state vs. coherent-state twisted pulses. We introduce the quantum correlator of photon spin density to characterize nonlocal spin noise providing a rigorous parallel with electronic spin noise. Our work can lead to quantum spin-OAM physics in twisted single-photon pulses and opens explorations for phases of light with long-range spin order.
An EKF based overlapping coalition formation game for cooperative wireless network navigation
Authors: Ke Mingxing , Tian Shiwei , Tong Kaixiang , Zhang Haiyan 
Published: September 2021

AbstractThe problem of efficient link selections for cooperative navigation is investigated in dynamic wireless networks, using an extended Kalman filter based overlapping coalition formation (OCF) game approach. Due to the densely deployment of nodes without proper link selections, the conventional cooperative navigation approaches usually yield high time‐frequency resources as the existing resource management methods only work properly in static localisation systems. A new link selection mechanism which is reliable with limited resources in dynamic positioning scenarios is proposed. The varying topological structure and states of every node will be taken into consideration while each node abandons a considerable number of unnecessary links. Firstly, the state of every mobile node will be estimated in real‐time. Then a selection criterion is applied to determine whether nodes are well navigated. If the criterion is satisfied, an OCF game will be employed to construct the effective link selection. Otherwise, a re‐link mechanism will be used to obtain precise state information of each node. Numerical results show that the cooperative navigation algorithm can significantly improve the positioning accuracy and the proposed OCF game approach can build a cooperative network with limited number of links at the cost of appropriate performance degradation.
Funnel function‐based asymptotic output feedback control of hydraulic systems with prescribed performance
Authors: Xu Zhangbao , Wang Yudong , Shen Hao , Liu Qingyun , Yao Jianyong 
Published: September 2021

AbstractAn asymptotic output feedback controller for the hydraulic systems with model uncertainty compensation and prescribed performance is proposed here, where state observers, funnel function and nonlinear adaptive controller are integrated via backstepping technology. Only position signal is available in the process of controller design, the velocity and load pressure are estimated by observers. And, the adaptive control law is carried out to approximate disturbance. Then, a funnel function is introduced to guarantee the prescribed tracking error performance and the potential singularity problem in prescribed performance control is avoided. Furthermore, the whole closed system is proved to be asymptotically stable using Lyapunov method. Comparative experimental results performed on hydraulic systems are studied to illustrate the effectiveness of the proposed controller.
Recursive fusion estimation for mobile robot localization under multiple energy harvesting sensors
Authors: Lu Yanyang , Karimi Hamid Reza 
Published: September 2021

AbstractThis paper is concerned with the recursive fusion estimation‐based mobile robot localization (RL) problem by employing multiple energy harvesting sensors (EHSs). In the addressed RL problem, multiple sensors with energy harvesting capacity are deployed to produce measurements used for RL. When the sensors own sufficient energy, the sensors can output measurements and then send them to the corresponding local filter. Otherwise, the sensor energy‐induced missing measurement phenomenon will occur. In order to obtain the missing measurement rate, at each time instant, the relationship between the totality of the sensor energy and its probability distribution is derived recursively. This paper aims at seeking out a practicable solution to the addressed mobile RL problem. First, in the presence of the sensor energy‐induced measurement missing phenomenon, an upper bound (UB) of the local localization error covariance is recursively acquired. Then, such a derived UB is minimized by suitably devising the desired local filter parameter. Subsequently, the covariance intersection fusion method is adopted to achieve the addressed RL problem. In the end, a simulation is conducted to verify the practicability of the developed RL scheme.
Real‐time predictive coordination based on vehicle‐triggered platoon dispersion in a low penetration connected vehicle environment
Authors: Li Jiangchen , Peng Liqun , Qiu Tony Z. 
Published: September 2021

AbstractThe connected vehicle (CV) technology can benefit signal coordination with fine‐grained spatial and temporal vehicle and infrastructure data via real‐time communication. Although CV‐based signal coordination systems have been investigated from offline and online strategic perspectives, existing works have yet to address certain coordination performance issues, including the dynamic platoon dispersion effect and low penetration impact. Targeting at resolving these issues, this work proposes a real‐time predictive coordination method consisting of a probabilistic single‐vehicle‐based dynamic platoon dispersion model, an extended link performance function, and a real‐time model predictive control (MPC)‐based coordination framework. The proposed coordination method was comprehensively investigated by a software‐in‐loop simulation platform with different practical corridor scenarios in the ACTIVE CV testbed in Canada. Results show the proposed coordination control continuously outperformed existing signal control with lower delays for major streets with different demand profiles and different CV penetration rates, even in low penetration conditions. In conclusion, the proposed CV MPC‐based coordination can offer significant potential to further improve the system performance of signal coordination in a low penetration environment; therefore, it has the potential to enhance other CV‐based signal control applications in the initial deployment stage of CV technology.
Urban development with dynamic digital twins in Helsinki city
Authors: Hämäläinen Mervi 
Published: September 2021

AbstractA dynamic digital twin is a feasible solution that can be employed to build real‐time connectivity between virtual and physical objects. Industries like manufacturing, aerospace and healthcare utilise dynamic digital twins for simulation, monitoring and control purposes, but recently, this nascent technology has also attracted the interest of urban designers. Due to the novelty of the dynamic digital twin in urban design, this research study addresses the concept of digital twin technology and investigates its applicability in so‐called smart city settings. Drawing on results from research interviews and examples from the Digital Twin project in Helsinki city, the research illustrates that solid data infrastructure forms the foundation for urban digital twins and the development of future smart city applications and services. Furthermore, data‐enriched digital twins evidently accelerate smart city experimentations and strengthen both learning and knowledge‐based decision‐making. Digital twins have also proved that they offer an environment in which smart city practitioners can bridge multi‐stakeholder urban design teams through one digital platform.
CHEOPS precision phase curve of the Super-Earth 55 Cancri e
Authors: Morris B. M. , Delrez L. , Brandeker A. , Cameron A. C. , Simon A. E. , Futyan D. , Olofsson G. , Hoyer S. , Fortier A. , Demory B.-O. , Lendl M. , Wilson T. G. , Oshagh M. , Heng K. , Ehrenreich D. , Sulis S. , Alibert Y. , Alonso R. , Anglada Escudé G. , Barrado D. , Barros S. C. C. , Baumjohann W. , Beck M. , Beck T. , Bekkelien A. , Benz W. , Bergomi M. , Billot N. , Bonfils X. , Bourrier V. , Broeg C. , Bárczy T. , Cabrera J. , Charnoz S. , Davies M. B. , De Miguel Ferreras D. , Deleuil M. , Deline A. , Demangeon O. D. S. , Erikson A. , Floren H. G. , Fossati L. , Fridlund M. , Gandolfi D. , García Muñoz A. , Gillon M. , Guedel M. , Guterman P. , Isaak K. , Kiss L. , Laskar J. , Lecavelier des Etangs A. , Lieder M. , Lovis C. , Magrin D. , Maxted P. F. L. , Nascimbeni V. , Ottensamer R. , Pagano I. , Pallé E. , Peter G. , Piotto G. , Pizarro Rubio A. , Pollacco D. , Pozuelos F. J. , Queloz D. , Ragazzoni R. , Rando N. , Rauer H. , Ribas I. , Santos N. C. , Scandariato G. , Smith A. M. S. , Sousa S. G. , Steller M. , Szabó Gy. M. , Ségransan D. , Thomas N. , Udry S. , Ulmer B. , Van Grootel V. , Walton N. A. 
Published: September 2021

Context. 55 Cnc e is a transiting super-Earth (radius 1.88 R⊕ and mass 8 M⊕) orbiting a G8V host star on a 17-h orbit. Spitzer observations of the planet’s phase curve at 4.5 μm revealed a time-varying occultation depth, and MOST optical observations are consistent with a time-varying phase curve amplitude and phase offset of maximum light. Both broadband and high-resolution spectroscopic analyses are consistent with either a high mean molecular weight atmosphere or no atmosphere for planet e. A long-term photometric monitoring campaign on an independent optical telescope is needed to probe the variability in this system.
Aims. We seek to measure the phase variations of 55 Cnc e with a broadband optical filter with the 30 cm effective aperture space telescope CHEOPS and explore how the precision photometry narrows down the range of possible scenarios.
Methods. We observed 55 Cnc for 1.6 orbital phases in March of 2020. We designed a phase curve detrending toolkit for CHEOPS photometry which allowed us to study the underlying flux variations in the 55 Cnc system.
Results. We detected a phase variation with a full-amplitude of 72 ± 7 ppm, but did not detect a significant secondary eclipse of the planet. The shape of the phase variation resembles that of a piecewise-Lambertian; however, the non-detection of the planetary secondary eclipse, and the large amplitude of the variations exclude reflection from the planetary surface as a possible origin of the observed phase variations. They are also likely incompatible with magnetospheric interactions between the star and planet, but may imply that circumplanetary or circumstellar material modulate the flux of the system.
Conclusions. This year, further precision photometry of 55 Cnc from CHEOPS will measure variations in the phase curve amplitude and shape over time.
Magnetic reconnection and the Kelvin-Helmholtz instability in the solar corona
Authors: Howson T. A. , De Moortel I. , Pontin D. I. 
Published: September 2021

Context. The magnetic Kelvin-Helmholtz instability (KHI) has been proposed as a means of generating magnetohydrodynamic turbulence and encouraging wave energy dissipation in the solar corona, particularly within transversely oscillating loops.
Aims. Our goal is to determine whether the KHI encourages magnetic reconnection in oscillating flux tubes in the solar corona. This will establish whether the instability enhances the dissipation rate of energy stored in the magnetic field.
Methods. We conducted a series of three-dimensional magnetohydrodynamic simulations of the KHI excited by an oscillating velocity shear. We investigated the effects of numerical resolution, field line length, and background currents on the growth rate of the KHI and on the subsequent rate of magnetic reconnection.
Results. The KHI is able to trigger magnetic reconnection in all cases, with the highest rates occurring during the initial growth phase. Reconnection is found to occur preferentially along the boundaries of Kelvin-Helmholtz vortices, where the shear in the velocity and magnetic fields is greatest. The estimated rate of reconnection is found to be lowest in simulations where the KHI growth rate is reduced. For example, this is the case for shorter field lines or due to shear in the background field.
Conclusions. In non-ideal regimes, the onset of the instability causes the local reconnection of magnetic field lines and enhances the rate of coronal wave heating. However, we found that if the equilibrium magnetic field is sheared across the Kelvin-Helmholtz mixing layer, the instability does not significantly enhance the rate of reconnection of the background field, despite the free energy associated with the non-potential field.
Residuale axilläre Metastasenlast nach neoadjuvanter Chemotherapie (NACT) bei Patientinnen mit Mammakarzinom im Frühstadium und a priori klinisch okkulten Lymphknotenmetastasen – eine transSENTINA-Analyse
Authors: Kolberg Hans-Christian , Kühn Thorsten , Krajewska Maja , Bauerfeind Ingo , Fehm Tanja N. , Fleige Barbara , Helms Gisela , Lebeau Annette , Stäbler Annette , Schmatloch Sabine , Hauschild Maik , Schwentner Lukas , Schrenk Peter , Loibl Sibylle , Untch Michael , Kolberg-Liedtke Cornelia 
Published: September 2021

Zusammenfassung
Hintergrund Der Zusammenhang zwischen pathologischer Komplettremission (pCR) der Brust und klinischen/pathologischen Parametern ist bei Brustkrebspatientinnen, die sich einer neoadjuvanten Chemotherapie (NACT) unterziehen, bekannt. Noch nicht geklärt ist aber der Zusammenhang zwischen diesen Parametern und der residualen axillären Lymphknotenlast nach NACT.
Methoden In dieser Studie wurden Patientinnen mit klinisch okkulten Lymphknotenmetastasen (d. h. klinisch negativ, aber SLN-positiv vor NACT; d. h. aus dem Arm B der SENTINA-Studie) aufgenommen. Bei allen Patientinnen wurden eine zweite Sentinel-Lymphknoten-Biopsie (SLNB) sowie eine axilläre Lymphknotendissektion nach NACT durchgeführt. Es wurden univariate und multivariate Analysen durchgeführt, um den Zusammenhang zwischen klinischen/pathologischen Parametern und axillärem Lymphknotenbefall nach NACT zu bestimmen.
Ergebnisse Es wurden 360 Patientinnen aus dem Arm B der SENTINA-Studie in diese Studie aufgenommen; die Daten von 318 dieser Patientinnen wurden analysiert. Nach der NACT wurde bei 71/318 (22,3 %) Patientinnen ein Befall der SLN oder Non-SLN festgestellt. Bei insgesamt 71/318 (22,3 %) Patientinnen konnte eine pCR der Brust erreicht werden. Der Zusammenhang zwischen extranodaler Ausbreitung, fehlender Multifokalität sowie pCR der Brust und der residualen axillären Lymphknotenlast war statistisch signifikant. Bei der deskriptiven Analyse aller Patientinnen mit klinisch negativen axillären Lymphknoten vor NACT in der SENTINA-Studie hatten 1,2 % der triplenegativen (TN) Patientinnen und 0,5 % der HER/2-positiven Patientinnen eine residuale axilläre Tumorlast trotz pCR der Brust.
Schlussfolgerung Patientinnen der SENTINA-Studie mit klinisch negativen axillären Lymphknoten und Sentinel-Lymphknoten-Befall haben ein signifikantes Risiko für nodale Metastasen nach NACT. Allerdings ist das Risiko einer residualen axillären Tumorlast besonders gering bei Frauen mit pathologischer Komplettremission der Brust und triplenegativen oder HER/2-positiven Tumoren.
Extending treatment criteria for Barrett’s neoplasia: results of a nationwide cohort of 138 endoscopic submucosal dissection procedures
Authors: van Munster Sanne N. , Verheij Eva P. D. , Nieuwenhuis Esther A. , Offerhaus Johan G. J. A. , Meijer Sybren L. , Brosens Lodewijk A. A. , Weusten Bas L. A. M. , Alkhalaf Alaa , Schenk Ed B. E. , Schoon Erik J. , Curvers Wouter L. , van Tilburg Laurelle , van de Ven Steffi E. M. , Tang Thjon J. , Nagengast Wouter B. , Houben Martin H. M. G. , Seldenrijk Kees C. A. , Bergman Jacques J. G. H. M. , Koch Arjun D. , Pouw Roos E. ,   on behalf of the Dutch Barrett Expert Centers
Published: September 2021

Background The use of endoscopic submucosal dissection (ESD) is gradually expanding for treatment of neoplasia in Barrett’s esophagus (BE). We aimed to report outcomes of all ESDs for BE neoplasia performed in the Netherlands.
Methods Retrospective assessment of outcomes, using treatment and follow-up data from a joint database.
Results 130/138 patients had complete ESDs, with 126/130 (97 %) en bloc resections. Median (interquartile range (IQR)) procedure time was 121 minutes (90–180). Pathology findings were high grade dysplasia (HGD) (5 %) or esophageal adenocarcinoma (EAC) T1a (43 %) or T1b (52 %; 19 % sm1, 33 % ≥ sm2). Among resections of HGD or T1a EAC lesions, 87 % (95 %CI 75 %–92 %) were both en bloc and R0; the corresponding value for T1b EAC lesions was 49 % (36 %–60 %). Among R1 resections, 10/34 (29 %) showed residual cancer, all detected at first endoscopic follow-up. The remaining 24 patients (71 %) showed no residual neoplasia. Six of these patients underwent surgery with no residual tumor; the remaining 18 underwent endoscopic follow-up during median 31 months with 1 local recurrence (annual recurrence rate 2 %). Among R0 resections, annual local recurrence rate during median 27 months was 0.5 %.
Conclusion In expert hands, ESD allows safe removal of bulky intraluminal neoplasia and submucosal cancer. ESD of the latter showed R1 resection margins in 50 %, yet only one third had persisting neoplasia at follow-up. To better stratify R1 patients with an indication for additional surgery, repeat endoscopy after healing of the ESD might be a helpful possible prognostic factor for residual cancer.
Stepwise Treatment for Abnormally Invasive Placenta with Placenta Previa
Authors: Sumigama Seiji , Kotani Tomomi , Hayakawa Hiromi 
Published: September 2021

AbstractPlacenta accreta spectrum (PAS) disorder often causes a large amount of intraoperative bleeding in a short period which makes maternal circulation unstable and threatens life. As a countermeasure, two-stage surgery combined with selective uterine arterial embolization (UAE), named “stepwise treatment” was introduced in 2003. At a cesarean section (CS), only the baby is delivered and the placenta is left in situ. The transcatheter angiographic UAE is performed on the operation day, followed by the total hysterectomy on 5 to 7 days after CS. The difficulty in the operative procedures for hysterectomy and the amount of bleeding can be reduced by the added effect of the blood flow interruption by UAE and the uterine involution. Although there are not many indication cases, this is the prudent operation that should be considered for the most severe PAS case such as total placenta increta/percreta with placenta previa.In this article, the practical procedures and tips of stepwise treatment are described.