bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Are the Mealtime Experiences of People in Residential Aged Care Facilities Informed by Policy and Best Practice Guidelines? A Scoping Review
Authors: Koh Grace , Thirumanickam Abirami , Attrill Stacie 
Published: December 2021

Abstract
Background. Mealtimes are embedded routines of residents living in residential aged care facilities (RACFs) that directly impacts their health and quality of life. Little is known about how mealtime experiences are informed and affected by structures such as government and organisational policies and processes. This scoping review used Gidden’s (1984) Structuration Theory to investigate how governance structures related to mealtime practices inform residents’ mealtime experiences. Methods. Using Arksey and O’Malley’s (2005) scoping review framework, a systematic database, grey literature and policy search was completed in May 2020 and updated in July 2021. From 2725 identified articles, 137 articles were included for in data charting and deductive analysis, and 76 additional Australian government policy papers were used interpretatively. Results. Data charting identified that the included studies were prominently situated in Western countries, with a progressive increase in publication rate over the past two decades. Qualitative findings captured structures that guide RACF mealtimes, how these relate to person-centred mealtime practices, and how these facilitate residents to enact choice and control. Conclusions. Current policies lack specificity to inform the specific structures and practices of RACF mealtimes. Staff, residents, organisational and governance representatives possess different signification, legitimation and domination structures, and lack a shared understanding of policy, and how this influences processes and practices that comprise mealtimes.
Study on the Distribution of Frictional Forces on Z-Yarn Continuous Implanted Preforms and Its Application
Authors: Guo Zitong , Shan Zhongde , Huang JiHua , Xue Debo 
Published: December 2021

Abstract
In order to improve the quality and efficiency of the Z-directional 3D preform forming, the Z-yarn friction force distribution model of the preform and its wear mechanism were investigated. Designed the tensile force measuring device of the replacement guide sleeves,the measured tensile force is equivalent to the Z-yarn friction force. Found that the frictional force was proportional to the number of preform layers, the frictional force applied to the one preform decreased from the corner, edge, sub-edge and middle in order. Established BP neural network model to predict the friction at different positions of preform with different layers, the error is within1.9%. The wear of Z-yarn was studied at different frictional positions and after different times of successive implantation into the preform, showed that with the increase of the number of Z-yarn implantation and the friction force, the amount of carbon fiber bundle hairiness gradually increase, and the tensile fracture strength damage of the fiber is increasingly affected by the friction force,and in the corner position of the preform, when the number of implantation is 25 times, the fiber fracture strength will occur non-linearly and substantially decreased, in order to avoid fiber fracture in the implantation process, the Z-yarn needs to be replaced in time after 20~25 times of continuous
Transcriptome Analysis of Umbilical Cord Mesenchymal Stem Cells Revealed Fetal Programming Due to Chorioamnionitis
Authors: Noguchi Yusuke , Taki Atsuko , Honda Izumi , Sugie Manabu , Shidei Tsunanori , Ito Kazuyuki , Iwata Haruka , Koyama Akira , Okazaki Kaoru , Kondo Masatoshi , Morioka Chikako , Kashimada Kenichi , Morio Tomohiro 
Published: December 2021

Abstract
Although chorioamnionitis (CAM) has been demonstrated to be associated with numerous short- and long-term morbidities, the precise mechanisms remain unclear. One of the reasons for this is the lack of appropriate models for analyzing the relationship between the fetal environment and chorioamnionitis and fetal programming in humans. In this study, we aimed to clarify the fetal programming caused by CAM using the gene expression profiles of UCMSCs.. From nine preterm neonates with CAM (n=4) or without CAM (n=5), we established UCMSCs.The gene expression profiles obtained by RNA-seq analysis revealed distinctive changes in the CAM group USMSCs. The UCMSCs in the CAM group had a myofibroblast-like phenotype with significantly increased expression levels of myofibroblast-related genes, including α-smooth muscle actin (p<0.05). In the pathway analysis, the genes involved in DNA replication and G1 to S cell cycle control were remarkably decreased, suggesting that cellular proliferation was impaired, as confirmed by the cellular proliferation assay (p<0.01 ~ 0.05). Pathway analysis revealed that genes related to white fat cell differentiation were significantly increased. Our results could explain the long-term outcomes of patients who were exposed to CAM and revealed that UCMSCs could be an in vitro model of fetal programming affected by CAM.
The hip radiographic magnification correlates with patient’s BMI
Authors: Hornová Jana , Hrubina Maroš , Šťastný Eduard , Košková Andrea , Fulín Petr , Gallo Jiří , Pokorný David , Daniel Matej 
Published: December 2021

Abstract
Objective.

Obese patients have a higher prevalence of total hip arthroplasty (THA) and they are likely to experience a higher rate of pre-operative and post-operative complications. Pre-operative templating is a standard method of THA planning aiming to minimize the risk of complications. The accuracy of pre-operative templating depends on the knowledge of radiographic magnification factor. Whether and to what extent obesity affects radiographic magnification is not well described in literature. The purpose of this study was to determine whether obesity type affects hip radiographic magnification and quantify the relationship between the obesity measured and change in radiographic magnification.
Materials and Methods.

Digital radiographs of 303 patients who underwent THA were taken from clinical archives. The size of implanted femoral head was taken as an internal calibration marker to estimate hip radiographic magnification. Patients were stratified into obesity categories by body mass index (BMI). Patients’ mass, BMI, and body surface area (BSA) were studied as predictors of hip magnification.
Results.

There is a significant effect of obesity type on hip radiographic magnification (one-way ANOVA, p<0.001). The radiographic magnification correlates with patients’ mass (r=0.443, p<0.001), BMI (r=0.450, p<0.001) and BSA (r=0.443, p<0.001). For every 17 kg increase in patients’ mass, 5 kg/m2 increase in the BMI and for every 0.27 m2 in the BSA there is a 1 percent increase in the hip radiographic magnification. The increase in hip radiographic magnification with mass, BMI, and BSA is higher in females than in males.
Conclusion.

BMI could be used to estimate the increase in hip radiographic magnification due to obesity by adding 1% of magnification on average for each subsequent BMI category.
Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APP Swe Alzheimer’s Disease Mouse Model
Authors: Zamarbide Marta , Martinez-Pinilla Eva , Gil-Bea Francisco J , Yanagisawa Masashi , Franco Rafael , Pérez-Mediavilla Alberto 
Published: December 2021

Abstract
The free fatty acid FFA3 receptor (FFA3R) belongs to the superfamily of G-protein-coupled receptors (GPCRs). In the intestine and adipose tissue, it is involved in the regulation of energy metabolism but its function in the brain is unknown. We aimed, first, to investigate the expression of the receptor in the hippocampus of Alzheimer disease (AD) patients at different stages of the disease and, second, to assess whether genetic inactivation of the Ffar3 gene could affect the phenotypic features of the APPswe mouse model. The expression of transcripts for FFA receptors in post mortem human hippocampal samples and in the hippocampus of wild-type and transgenic mice was analyzed by RT-qPCR. We generated a double transgenic mouse, FFA3R-/-/APPswe, to perform cognition studies and to assess, by immunoblotting, Aβ and tau pathologies and the differential expression of synaptic plasticity-related proteins.For the first time, the occurrence of the FFA3R in the human hippocampus and its overexpression, even in the first stages of AD, was demonstrated. Remarkably, FFA3R-/-/APPswe mice do not have the characteristic memory impairment of 12-month-old APPswe mice. Also, this newly generated transgenic line does not develop the most important Alzheimer’s disease (AD)-related features, such as amyloid beta (Aβ) brain accumulations and tau hyperphosphorylation. These findings are accompanied by increased levels of the insulin-degrading enzyme (IDE) and lower activity of the tau kinases GSK3β and Cdk5. We conclude that the brain FFA3R is involved in cognitive processes and its inactivation prevents AD-like cognitive decline and pathological hallmarks.
N-Myc Downstream-Regulated Gene 2 (Ndrg2): A Critical Mediator of Estrogen-Induced Neuroprotection Against Cerebral Ischemic Injury
Authors: Zhang Lixia , Ma Yulong , Liu Min , Sun Miao , Wang Jin , Liu Siyuan , Guo Hang , Zhang Xiaoying , Hou Wugang , Liu Yanhong 
Published: December 2021

Abstract
Growing evidence indicates that estrogen plays a pivotal role in neuroprotection against cerebral ischemia, but the molecular mechanism of this protection is still elusive. N-myc downstream‐regulated gene 2 (Ndrg2), an estrogen-targeted gene, has been shown to exert neuroprotective effects against cerebral ischemia in male mice. However, the role of Ndrg2 in the neuroprotective effect of estrogen remains unknown. In this study, we first detected NDRG2 expression levels in the cortex and striatum in both female and male mice with western blot analyses. We then detected cerebral ischemic injury by constructing middle cerebral artery occlusion and reperfusion (MCAO-R) models in Ndrg2 knockout or conditional knockdown female mice. We further implemented estrogen, ERα or ERβ agonist replacement in the ovariectomized (OVX) Ndrg2 knockouts or conditional knockdowns female mice, then tested for NDRG2 expression, glial fibrillary acidic protein (GFAP) expression, and extent of cerebral ischemic injury. We found that NDRG2 expression was significantly higher in female than in male mice in both the cortex and striatum. Ndrg2 knockouts and conditional knockdowns showed significantly aggravated cerebral ischemic injury in female mice. Estrogen and ERβ replacement treatment (DPN) led to NDRG2 upregulation in both the cortex and striatum of OVX mice. Estrogen and DPN also led to GFAP upregulation in OVX mice. However, the effect of estrogen and DPN in activating astrocytes was lost in Ndrg2 knockouts OVX mice and primary cultured astrocytes, but partially retained in conditional knockdowns OVX mice. Most importantly, we found that the neuroprotective effects of E2 and DPN against cerebral ischemic injury were lost in Ndrg2 knockouts OVX mice but partially retained in conditional knockdowns OVX mice. These findings demonstrate that estrogen alleviated cerebral ischemic injury via ERβ upregulation of Ndrg2, which could activate astrocytes, indicating that Ndrg2 is a critical mediator of E2-induced neuroprotection against cerebral ischemic injury.
QTL Analysis Based on A Rice Short-Wide Grain CSSL-Z414 and Substitution Mapping of qGL11 and qGW5
Authors: Li Juan , Yang Hongxia , Xu Guangyi , Deng Keli , Yu Jinjin , Xiang Siqian , Zhou Kai , Zhang Qiuli , Li Ruxiang , Li Miaomiao , Ling Yinghua , Yang Zhenglin , He Guanghua , Zhao Fangming 
Published: December 2021

Abstract
Background: Most of rice agronomic traits as grain length etc. are complex traits controlled by multiple genes. Chromosome segment substitution lines (CSSLs) are ideal materials for dissecting and studying of these complex traits. Results: We developed a novel rice short-wide grain CSSL, Z414, deriving from progeny of the recipient parent Xihui 18 (an indica restorer line) and the donor parent Huhan 3 (a japonica cultivar). Z414 contained 4 substitution segments (average length was 3.04 Mb). Compared with Xihui 18, Z414 displayed seven significantly different traits as grain length, width and weight, chalkiness degree, brown rice rate etc. Then, 8 quantitative trait loci (QTLs) were found responding these difference traits by F2 population from Xihui 18/Z414. Among them, 6 QTLs (qPL3, qGW5, qGL11, qRLW5, qRLW11, qGWT5) could be verified by novel developed single segment substitution lines (SSSLs, S1-S6). In addition, 4 QTLs (qGL3, qGL5, qCD3 and qCD5) were novel detected by S1 and S5. Thus, the short–wide grain of Z414 was responded by qGL11, qGL3, qGL5, and qGW5. Then, qGL11 and qGW5 were delimited within intervals of 0.405 and 1.14 Mb on chromosomes 11 and 5, respectively, by substitution mapping. Again by sequencing, qRT-PCR and cell morphology analysis, qGW5 should be a novel allele of GS5 and qGL11 is novel QTL encoding CycT1;3, whose specific function of regulating grain length was still unknown. Finally, pyramid of qGL3 (a=0.22) and qGL11 (a=-0.19) displayed qGL11 epistatic to qGL3. In addition, novel S1 and D2 exhibited different grain sizes and lower chalkiness degree. They are potential to be directly used in breeding hybrid rice varieties.Conclusions: We constructed a novel rice short–wide grain CSSL-Z414 with 4 substitution segments based on the genetic backgrounds of Xihui 18. The broad grain of Z414 was controlled by qGW5, which should be a novel allele of GS5. The short grain of Z414 was controlled by qGL11, qGL3, and qGL5, and qGL11 is a novel QTL encoding CycT1;3, whose specific function of regulating grain length was still unknown, and qGL11 is epistatic to qGL3. Novel S1 and D2 are potential in hybrid rice varieties.
Microstructure and Nanomechanical Property of Plasma-Sprayed Nanostructured Yb2SiO5 Environmental Barrier Coatings
Authors: Zheng Tao , Xu Baosheng , Wang Shun , Guo Donghui , Zhou Feifei , Yang Yazheng , Fang Daining 
Published: December 2021

Abstract
In this study, nanostructured Yb2SiO5 coatings were prepared by atmospheric plasma spraying (APS) using nanostructured Yb2SiO5 feedstocks. Conventional Yb2SiO5 coatings were selected for comparison. The microstructure and nanomechanical property of the nanostructured and conventional Yb2SiO5 coatings were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and nano-indentation. Results indicate that the surface of the nanostructured Yb2SiO5 coatings is uniform and denser than the conventional Yb2SiO5 coatings. In addition, Weibull distribution analysis shows that the molten state of the nanostructured Yb2SiO5 coatings present a mono-modal distribution, whereas the conventional Yb2SiO5 coatings show a bi-modal distribution, i.e. molten and unmelted zones. The nanostructured Yb2SiO5 coatings have a higher elastic modulus than the conventional Yb2SiO5 coatings (167.37077 ± 16.88070 GPa versus 153.72856 ± 19.69907 GPa), reflecting their high density.
The Low Expression of MEOX2 is Associated With Poorer Survival in Breast Cancer
Authors: Wang Huxia , Tang Yanan , Wang Meixia , Ding Caixia , Yang Xiaomin , Han Pihua , Zhao Jing , Liu Peijun 
Published: December 2021

Abstract
The regulation of vertebrate limb myogenesis gene, Mesenchyme Homeobox 2 (MEOX2), has been reported to be associated with most cancer progression closely. However, its role and function in breast cancer are unidentified. Here, we aim to investigate the association of MEOX2 expression with clinicopathological features and the survival probability of breast cancer. The MEOX2 expression in breast cancer was first analyzed from The Cancer Genome Atlas (TCGA) database. Then, the association of MEOX2 with patients’ clinicopathological variables and prognostic probability were detected by bioinformatics analysis. Moreover, a high-throughput tissue microarray containing 135 cases of breast cancer was used to further clarify the expression of MEOX2 in breast cancer patients. The expression of MEOX2 is inhibited in breast cancer than in normal tissues, and the lower MEOX2 expression indicates the poorer prognosis of breast cancer patients. In addition, the histological grade of MEOX2 expression is negatively correlated with the Ki67 level. Multivariate COX regression also verified that MEOX2 was an independent prognostic factor in breast cancer patients. Based on our results, we can conclude that lower MEOX2 expression was related to tumor proliferation and could be a new diagnostic and prognostic biomarker of breast cancer.
Metabarcoding of Soil Fungal Communities from Perturbed Areas Reveal Drive Role of Environmental Factors in Microbial Diversity of Colombian Andosols
Authors: AROCA RAUL ALEXANDER ARANGUREN , Voyron Samuele , Ungaro Fabrizio , Cañón Julio , Lumini Erica 
Published: December 2021

Abstract
Changes in soil fungal community caused by land use have not been sufficiently studied in South-American Andosols, considered globally as important food production areas. This study analyzed 26 soil samples of Andosols collected from locations devoted to conservation, agriculture and mining activities in the southeastern region of Antioquia, Colombia, to establish differences between fungal communities as indicators of the degree of soil perturbation. The study developed a novel heminested PCR with primers SSUmCf Mix, ITS4 and fITS7 to assess Arbuscular Mycorrhizal Fungi detection in a Illumina MiSeq metabarcoding on nuclear ribosomal ITS2 region. A non-metric multidimensional scaling allowed exploring driver factors of fungal community changes, while fitted Dirichlet-multinomial models and PERMANOVA tests allowed identifying the correlations between alpha diversity indexes and community dissimilarities, as well as the significance of land use effects on fungal community composition. Furthermore, response ratios were determined to assess effect size by land use over relevant taxa. Results suggest a good coverage of fungal diversity with a detection of 10,529 high-quality ITS2 sequences belonged to phylum Glomeromycota. The analysis shows strong correlations of Shannon and Fisher indexes with dissimilarities on fungal communities among land uses (r=0.94), related to variations in temperature, air humidity and organic matter contents that lead to significant responses in abundances of relevant orders (such as Wallemiales and Trichosporonales). The study highlights the rich fungal biodiversity of the tropical Andosols, their specific sensitivities to environmental perturbation factors, and the useful range of a metabarcoding approach to characterize soil fungal communities.
Clinical Outcomes of Single Excision Versus Kidner Procedure for Type II Accessory Navicular Associated with Flatfoot in Adults: Does accessory navicular induce flexible flatfoot?
Authors: Tao Xu , Yang Qian dong , Wang Zhenyu , Wang Wei , Tang Kang Lai 
Published: December 2021

Abstract
Background
Patients with type II accessory navicular (AN) originally complain of the medial pain of foot. With increasing frequency, some of them has been recognized flexible flatfoot (FFF) at the first weightbearing radiographic examination. Posterior tibial tendon (PTT) dysfunction is widely accepted as a significant contributor to FFF. However, the PTT was not affected in these patients. The relationship between AN and FFF remains controversial. The contribution of AN to FFF was designed in this study.
Methods
Adult patients who complained of medial pain and bone eminence between January 2014 and January 2020 were included. 61 patients were confirmed to have the AN with flatfoot and randomly divided into two operative groups. The AN was excised in Group A, and the PTT was reconstructed to the navicular region with an anchor in Group B. Preoperative and postoperative evaluations were performed, including clinical evaluations, the American Orthopedic Foot and Ankle Society (AOFAS) mid-foot scale, a visual analog scale (VAS) and radiographic assessments of Meary’s angle, Pitch angle, talonavicular coverage, Kite’s angle and naviculocuboid overlap. PTT decline angle (PDA) and AN-Navicular joint inclination angle (ANJCA) in the lateral view were designed to evaluate the effect of AN on FFF.
Results
Fifty-six patients (56 feet) were included in this study because 5 patients were excluded. The mean follow-up period was 22.29 months with single excision (Group A) and 20.86 months with Kidner procedure (Group B). The AOFAS mid-foot score improved from 70.39±7.78 pre-operationally to 89.46±7.06 at the last follow-up in Group A and from 67.14±8.14 pre-operationally to 89.64±6.88 at the last follow-up in Group B. The VAS score decreased from 2.82±0.39 and 2.86±0.36 to 0.89±0.31 and 0.79±0.42, respectively. The radiographic results representing flatfoot significantly increased in the two groups. In the lateral view, PDA significantly increased after the operation, and the effect of PTT on the arch upward was induced by pull angulations and shorter distances.
Conclusion
The FFF with AN may be induced by AN and its synchondrosis. The weakened plantar ligament of synchondrosis was impaired under chronic tension and shear forces may be implicated as the etiologic biomechanical mechanism. AN excision or it with PTT reconstruction could release the pain and benefit the PTT pulling sufficiency.
Quantum Correlated Heat Engine In XY Chainwith Dzyaloshinskii-Moriya Interactions
Authors: Asadian M. , Ahadpour S. , Mirmasoudi F. 
Published: December 2021

Abstract
In this paper, we consider a heat engines composed of two interactionalqubits with spin-orbit interaction (Dzyaloshinskii–Moriya (DM)) subjectto an external magnetic field, so that each qubit is considered as a cold orhot source. One intention of this work is to investigate the following question: is it possible the effects of DM lead to improve basic thermodynamicquantities in this heat engine are coupled to local environments that arenot necessarily at equilibrium? For this end, we investigate the effects ofthe temperature and the interaction rate of each qubit with its surrounding environment on quantum correlations such as quantum coherence andquantum discord and quantum entanglements, as well as the generatedwork. Finally we compare three quantum correlations (entanglement, discord, and coherence) with thermodynamic parameters and show that theoutput work is positive for what values of the magnetic field so that thiscycle can be considered as a thermal machine.
A Facile Colorimetric Method For Ultra-Rapid And Sensitive Detection of Copper Ions In Water
Authors: Chen Lei , Li Yan , Sun Ping , Chen Hualin , Li He , Liu Jun , Chen Ziyue , Wang Bin 
Published: December 2021

Abstract
It is of great meaning to develop a facile, reliable and sensitive method to detect copper ions in water. In the study, a facile method has been developed for rapid and sensitive detection of Cu2+. An interesting phenomenon has been observed that 3,3',5,5'-tetramethylbenzidine (TMB) ethanol solution can be extremely fast passed from colorless to yellow once Cu2+ ions are added. It easily occurs to us that Cu2+ can be quantitatively determined via the absorbance at 904 nm of the color changed TMB solution. More importantly, some specific anions (Cl- , Br- ) can significantly enhance the absorption intensity. Under the optimized experimental conditions, this method exhibits a good linear response range for Cu2+ from 0.5 to 100 μM, with the detection limit of 93 nM. Moreover, the possible detection principle has been explored. It is worth mentioning that the color change can be clearly observed by naked eyes for the detection of 1 μM Cu2+, which is far below the threshold limit of Cu2+ in drinking water suggested by World Health Organization. It means that this method possess great promise for on-site Cu2+ detection.