bluuebunny/crossref_metadata_2025_split huggingface dataset:
RV reducer Design Using Resnet-based model and integration of Discretized OPtimization
Authors: Miao Jiacheng , Li Chaoyang , Chen Bingkui 
Published: July 2021

Abstract
A new type of mechanical system structure design model is proposed, which uses a small number of system feature samples to generate a new structure model. In this model, (1) the theory of limited sample recommendation algorithm is used to study the external dimensions recommendation of the reducer, an SG-Resnet network suitable for the generation of reducer structure parameters is established, the main factors affecting the promotion ability and learning rate of the SG-Resnet network structure are analyzed through hyperparameters, and in-depth study of the mechanism of each influencing factor. (2) Establish an optimization design method for the internal dimensions of the reducer, and initially calculate the structural parameters according to the basic performance parameters of the reducer, combine the objective function and constraint conditions to establish the corresponding multi-objective optimization model, and establish the Kriging proxy model. The mixed population NSGA-II algorithm is proposed, the MP-NSGA-II algorithm is used to obtain multiple sets of Pareto optimal solutions, and the multi-objective evaluation method is used to select the optimal solution from the non-dominated solution set. Experiments were carried out to verify the positive enhancement effect of the structural design model on the stiffness of the reducer. The experiment showed the reliability and generalizability of the model. This research provides a new solution for reducer design and lays a solid foundation for the development of integrated RV reducer forward design software.
Hydroxytyrosol Effectively Improves The Quality of Pig Sperm at 17 ℃
Authors: Li Dong , Zhang Wenyu , Tian Xuekai , He Yulin , Xiao Zitong , Zhao Xin , Du Renrang , Yang Gongshe , Yu Taiyong 
Published: July 2021

Abstract
Background: Artificial insemination technology is the production technology used in more than 99% of the world's pig farms. As the frozen sperm damage is very serious, the preservation of pig sperm is mainly carried out at 17°C. However, the accumulation of a large amount of reactive oxygen species (ROS) during the preservation process is the main reason for the deterioration of sperm quality. In our research, by adding different concentrations of hydroxytyrosol to the diluent during the storage of pig sperm at 17°C, we compared them with the traditional diluent to study the cumulative amount of ROS, the extent of membrane damage, the sperm acrosome integrity, the activity of antioxidant enzymes, and other indicators to evaluate the effect of hydroxytyrosol on the changes of active oxygen species and sperm quality during storage. After we determined the optimal amount of hydroxytyrosol in the diluent, proteomics was used to monitor difference in sperm protein expression between the control group and the addition of 120 μmol/L hydroxytyrosol group (optimum concentration). Ultimately, we selected the control group and the 120 μmol/L hydroxytyrosol group to test the effect of artificial insemination.Results: The results of our research showed that during storage of pig sperm at 17 ℃, the sperm quality and antioxidant capacity of the hydroxytyrosol-treated group was significantly improved (P < 0.05). Proteomics sequencing analysis proved that the addition of hydroxytyrosol treatment group has potential value in improving sperm quality. Besides, the significant increase in sow pregnancy rate and piglet birth weight also confirmed that sperm quality during storage can be of vital importance in actual production (P < 0.05).Conclusions: Based on our results, we demonstrate that the addition of hydroxytyrosol to the diluent could improve the quality of pig sperm and the efficiency of artificial insemination.
Esophageal Carcinosarcoma Comprising of Undifferentiated Pleomorphic Sarcoma and Squamous Cell Carcinoma: A Case Report
Authors: Fang Ziyao , Pan Shu , Xu Chun , Ju Sheng , Shen Ziqing , Zhao Jun 
Published: July 2021

Abstract
Introduction: Esophageal carcinosarcoma (ECS) is a rare malignant tumor that often presents as an intraluminal polypoid lesion in the esophageal lumen. Herein we present a case diagnosed as esophageal carcinosarcoma and treated with esophagectomy.Case presentation: A 68-year-old male patient was presented to the thoracic surgery department complaining of dysphagia for about three months. He was diagnosed with ECS and underwent uniport video-assisted thoracic surgery (VATS). Based on the histopathological reports, the patient was finally diagnosed as ECS, clinical T1bN0M0, pathological stage I. 11 days after the surgery, the patient was discharged from the hospital without experiencing any complications.Conclusion: Carcinosarcoma was first described by Virchow in 1865 as a rare malignant neoplasm. The clinical manifestations of ECS includes dysphagia, chest pain and weight loss. IHC analysis indicates carcinoma and the sarcoma occurred independently. Complete resection of the esophagus with lymphadenectomy of locoregional nodes is still recommended as the best potentially curative treatment. For the prognosis of ECS compared to (ESCC), there is a controversy. Here, we reported a case of ECS comprising of squamous cell carcinoma in situ and undifferentiated pleomorphic sarcoma underwent uniport VATS esophagectomy with no serious complications, which indicate that VATS esophagectomy could be applied to ECS patients.
Fabrication of Easy Separable and Reusable Adsorbent Composite based on MIL-125/MIL-53 Binary MOF/CNT/Alginate Microbeads for Aremoval of Tetracycline from Water Bodies
Authors: Omer Ahmed M. , El-Monaem Eman M. Abd , El-Subruiti Gehan M. , El-Latif Mona M. Abd , Eltaweil Abdelazeem S. 
Published: July 2021

Abstract
During the turbulent period of COVID-19, the medical staff is exerting great efforts to preserve humanity. However, the tons of pharmaceutical residues especially antibiotics that is being disposing daily into water bodies may be the seed to an even more ferocious pandemic. Thence, it is inevitable to find out effective strategies for removing these noxious pharmaceutical residues from water. We aimed in this investigation to fabricate easy separable composite microbeads for efficient adsorption of tetracycline (TC) drug. Herein, MIL-125/MIL-53 binary metal organic framework (MOF) was synthetized and incorporated with carbon nanotube (CNT) into alginate (Alg) microbeads to form MIL-125/MIL-53/CNT@Alg composite microbeads. Various tools including FTIR, XRD, SEM, BET, Zeta potential and XPS were applied to characterize the composite microbeads. The results revealed that the adsorption of TC was augmented with rising TC proportion up to 15 wt% in the microbeads matrix. In addition, the adsorption process followed the pseudo-second-order and well-fitted to Freundlich and Langmuir models with a maximum adsorption capacity of 294.12 mg/g at 25 ◦C, while the adsorption process was endothermic, randomness and spontaneous. Besides, reusability test signified that MIL-125/MIL-53/CNT@Alg composite microbeads retained admirable adsorption properties for six consecutive cycles, emphasizing its potentiality for removing of pharmaceutical residues.
N-Fuzzy Sets and Their Applications
Authors: Ibrahim Hariwan Z. 
Published: July 2021

Abstract
The purpose of this paper is to define n-Fuzzy sets and study their relationship with intuitionistic
fuzzy sets, Pythagorean fuzzy sets and Fermatean fuzzy sets. The n-Fuzzy sets can deal with more uncertain situations than intuitionistic fuzzy sets, Pythagorean fuzzy sets and Fermatean fuzzy sets because of its larger range of describing the membership grades. The set operations, score function, accuracy function and Euclidean distance of n-Fuzzy sets will study. Finally, we study the Sanchez$^{,}$s approach for medical diagnosis and extend this concept with the notion of n-Fuzzy set.
Differing Dietary Nutrients and Diet-associated Bacteria has Limited Impact on Spider Gut Microbiota Composition
Authors: Zhang Wang , Liu Fengjie , Zhu Yang , Han Runhua , Xu Letian , Liu Jie 
Published: July 2021

Abstract
Spiders are a key predator of insects across ecosystems and possess great potential as pest control agents. Unfortunately, it is difficult to artificially cultivate multiple generations of most spider species. Since gut bacterial flora has been shown to significantly alter nutrient availability, it is plausible that the spiders’ microbial community play a key role in their unsuccessful breeding. However, both the gut microbial composition and its influencing factors in many spiders remain a mystery. In this study, the gut microbiota of Campanicola campanulata, specialist prey on ants and are widely distributed across China, was characterized. After, the impact of diet and diet-associated bacteria on gut bacterial composition was evaluated. First, two species of prey ants (Lasius niger and Tetramorium caespitum) were collected from different locations and fed to C. campanulata. For each diet, we then profiled the nutritional content of the ants, as well as the bacterial communities of both the ants and spiders. Results showed that the protein and carbohydrate content varied between the two prey ant species, and that the bacterial communities of the ants were clearly delineated by collection site. However, no significant differences were found in the gut microbiota of spiders that were fed the differing ants. Together, these results indicate that nutritional variation and diet-associated bacterial differences have a limited impact on the microbial composition of spider guts, suggesting that spiders have a mechanism keeping their gut bacterial community stable to ensure normal physiological function and development.
Effects of carbidopa premedication on 18F-FDOPA PET imaging of brain tumors: a static, dynamic and radiomics analysis
Authors: Bros Marie , ZARAGORI Timothée , Rech Fabien , Blonski Marie , Hossu Gabriella , Taillandier Luc , Marie Pierre-Yves , VERGER Antoine 
Published: July 2021

Abstract
Purpose

This study aims to determine the impact of carbidopa premedication on static, dynamic and radiomics parameters of 18F-FDOPA PET imaging in brain tumors.
Material and Methods

The study included 54 patients that underwent 18F-FDOPA PET imaging for newly diagnosed gliomas. Among these, 18 patients received 100 mg of carbidopa. SUV parameters and 105 radiomics features were extracted from the static images. Dynamic data were available for 41 patients. Time to Peak (TTP) values were extracted from dynamic acquisitions. These parameters were obtained from volumes of interest in healthy brain as well as tumors. Simulation of the effects of carbidopa premedication on TTP values were also generated.
Results

All static and TTP dynamic parameters were significantly increased in healthy brain regions of premedicated patients (ΔSUVmean = + 53%, ΔTTP = + 48%, p < 0.001). Furthermore, carbidopa impacted 81% of radiomics features, of which 92% correlated with SUVmean (absolute correlation coefficient ≥ 0.4). In tumors, premedication with carbidopa was an independent predictor of SUVmean (ΔSUVmean = + 52%, p < 0.001) and TTP (ΔTTP = + 24%, p = 0.025). Interestingly, all parameters were no longer significantly modified by carbidopa premedication when using tumor-to-healthy-brain image and TAC ratios. Simulated data confirmed that carbidopa leads to an increase in tumor TTP values which is corrected by using these ratios.
Conclusion

In 18F-FDOPA PET brain imaging, carbidopa induces an increase of similar magnitude in SUV, SUV-dependent radiomics and TTP dynamic parameters in healthy brain and tumor regions which are compensated for after using the tumor-to-healthy-brain image and TAC ratios which is an important point for multicentric studies harmonization.
Sarcoidosis following Hematopoietic Stem Cell Transplantation: clinical characteristics and HLA associations
Authors: Wurm-Kuczera Rebecca Isabell , Büntzel Judith , König Julia Felicitas Leni , Legler Tobias , Valk Jan-Jakob , Hasenkamp Justin , Jung Wolfram , Rademacher Jan-Gerd , Korsten Peter , Wulf Gerald Georg 
Published: July 2021

Abstract
Purpose:

Extrinsic factors and genetic predisposition contribute to the etiology of sarcoidosis, converging in a phenotype of altered immune response associated with multisystemic inflammatory granulomatous tissue infiltration. Immunological reconstitution after hematopoietic stem cell transplantation (HSCT) may represent a unique window for the pathogenesis of the disease. We describe the incidence, clinicopathological features, and HLA associations of sarcoidosis after HSCT in a single-center cohort of patients, together with data from previously published cases.
Methods:

We retrospectively analyzed clinical characteristics and HLA haplotypes from allogeneic (allo) or autologous (auto) HSCT patients from January 2001 through May 2021 at the University Medicine Goettingen (UMG), and data from 15 previously published cases.
Results:

13 patients had received an allo HSCT, and six patients an auto HSCT, including four at our center (three allo HSCT, one auto HSCT). Sarcoidosis occurred after a median interval of 20 and 7 months, respectively. The predominant HLA allele associated with sarcoidosis was HLA DRB1*03:01. Sarcoidosis involved the respiratory tract in 15 patients (three unknown, one without pulmonary involvement), and it was associated with graft-versus-host disease in seven of 13 patients receiving allo HSCT. None of the donors or patients had a history of sarcoidosis before transplantation. Disease manifestations resolved by standard glucocorticoid treatment without long-term sequelae.
Conclusion:

Sarcoidosis may occur at low frequency during reconstitution of the immune system after HSCT. HLA allele associations reflect the associations observed in the general population, particularly with DRB1*03:01. Further insights into the interplay between T cell reconstitution and the development of sarcoidosis could also provide novel approaches to an improved understanding of the pathogenesis in sarcoidosis.
Discovery of BRCA1/BRCA2 Founder Variants by Haplotype Analysis
Authors: Kwon Won Kyung , Jang Hyeok-Jae , Lee Jeong Eon , Park Yeon Hee , Ryu Jai Min , Yu Jonghan , Jang Ja-Hyun , Kim Jong-Won 
Published: July 2021

Abstract
A significant number of hereditary breast or ovarian cancers are caused by germline variants, mostly BRCA1/BRCA2 genes. Because genetic predispositions vary by ethnicity, several studies have reported founder variants of BRCA1/BRCA2 genes. Such founder variants were reported primarily based on their relevant population frequencies. We reviewed the variant data relating to BRCA1 and BRCA2 genes from January, 2012 to March 2019 at Samsung Medical Center, Seoul, Korea. Among the cases with pathogenic variants (PVs) or likely pathogenic variants (LPVs), we defined recurrent variants as those found in more than five unrelated patients. Using single nucleotide polymorphisms, we analyzed patient haplotypes. There were 14 recurrent variants in the BRCA1 gene and seven variants in the BRCA2 gene. Of note, three variants in each gene were primarily detected in Korean populations. Among them, the c.5339T > C BRCA1 variant had a long block sized 74.5 kb. In BRCA2, the c.1399A > T variant had a long block sized 35.5 kb. We suggest that BRCA1 c.5339T > C and BRCA2 c.1399A > T are founder variants of the Korean population. These two recurrent variants were ethnicity-prevalent, primarily found in Korean populations, and the sizes of the linkage disequilibrium blocks are longer than others.
Integrated PET/MR for Resting State Functional and Metabolic Imaging in Human Brain: What is Correlated and What is Impacted
Authors: Shan Yi , Wang Zhe , Song Shuangshuang , Xue Qiaoyi , Yang Hongwei , Cui Bixiao , Zhang Miao , Zhou Yun , Lu Jie 
Published: July 2021

Abstract
Purpose

We aimed to, for the first time, investigate the interplay of simultaneous functional MRI (fMRI) and FDG PET using a randomized self-control protocol on an integrated PET/MR.
Materials and methods

24 healthy volunteers underwent PET/MR scan 30 to 40 minutes after the injection of FDG. A 22-minute brain scan was separated into MRI-off (without fMRI pulsing) and MRI-on modes (with fMRI pulsing) with each one lasting for 11 minutes. We calculated the voxel-wise fMRI metric (ReHo, ALFF, fALFF and DC), resting networks, relative standardized uptake value ratios (SUVr), Patlak Ki and regional cerebral metabolic rate of glucose (rCMRGlu) maps. Paired two-sample t-tests were applied to assess the statistical differences between SUVr, Ki, correlation coefficients of fMRI metrics and rCMRGlu between MRI-off and MRI-on mode, respectively.
Results

Voxel-wise whole brain SUVr in MRI-off mode and MRI-on mode revealed no statistical difference, while Ki was significantly elevated in the whole brain (P༜0.05) during fMRI scan. Task-based group ICA revealed that the most active network components derived from combined MRI-off and MRI-on static PET images were frontal pole, superior frontal gyrus, middle temporal gyrus and occipital pole. High correlation coefficients were found among the four-fMRI metrics with rCMRGlu in MRI-off and MRI-on mode (P༜0.05). The highest correlation coefficients between rCMRGlu and all fMRI metrics were found in the visual network (R, 0.523 ± 0.057) and default network (R, 0.461 ± 0.099).
Conclusions

Static PET quantitation SUVr as an indicator of the accumulative effect of FDG update post-injection does not exhibit immediate change between MRI-on and MRI-off modes. Dynamic PET quantitation Ki is instantly elevated during MRI-on mode due to the additional impact of MRI sequence on imaging subjects. Network connectivity analysis also demonstrated intermediate modulation of brain function in MRI-on mode as compared to MRI-off mode.
Differential Cardiovascular and Renal Benefits of SGLT2 Inhibitors and GLP1 Receptor Agonists in Patients With Type 2 Diabetes Mellitus
Authors: Kim Chee Hae , Hwang In-Chang , Ahn Chang Ho , Yoon Yeonyee E. , Cho Goo-Yeong 
Published: July 2021

Abstract
Background: The differential benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1RA) in cardiovascular or renal outcomes have not been fully investigated. This study sought to compare the real-world cardiovascular and renal outcomes between SGLT2i and GLP1RA in patients with type 2 diabetes.Methods: Patients with diabetes prescribed SGLT2i or GLP1RA were retrospectively identified. Patients treated with antihyperglycemic medications other than SGLT2i or GLP1RA were used as a control group. After 2:1:3 propensity score matching among 24,752 eligible patients, 614 patients treated with SGLT2i, 307 patients treated with GLP1RA, and 921 control patients were analyzed. Primary outcomes were composite ischemic events (acute coronary syndrome, coronary revascularization, and stroke) and a composite of heart failure and renal events (hospitalization for heart failure, renal death, initiation of renal replacement therapy, and renal admission). Serial changes in laboratory findings according to medication use were compared.Results: During a median 38.7 months of follow-up, the incidence of composite ischemic events tended to be lower in the GLP1RA group (annualized rate 0.82% per person-year) than in the other groups (1.68% per person-year in the SGLT2i group and 1.36% per person-year in the control group). The risk of a composite of heart failure and renal outcomes was significantly lower in the SGLT2i group than in the GLP1RA and control groups (0.86% per person-year, 2.33% per person-year, and 1.48% per person-year, respectively; SGLT2i vs. GLP1RA, hazard ratio [HR] 0.384, 95% confidence interval [CI] 0.194-0.763, p=0.006; SGLT2i vs. control, HR 0.426, 95% CI 0.242-0.751, p=0.003). The SGLT2i group had a slower decline in renal function over time compared to that in other groups.Conclusions: SGLT2i showed more benefits in heart failure and renal outcomes, whereas GLP1RA tended to have more favorable ischemic outcomes. The observed differential benefit profiles of SGLT2i and GLP1RA may be applied to the selection of antidiabetic medication in clinical practice.
Association Between Serum miR-221-3p and Intravenous Immunoglobulin Resistance in Children With Kawasaki Disease
Authors: Jing Fengchuan , Weng Haobo , Zhang Jing , Pei Qiongfei , Liu Ruixi , Yi Qijian 
Published: July 2021

Abstract
ObjectivesIntravenous immunoglobulin (IVIG) resistance was a major cause of coronary artery lesions in children with Kawasaki disease (KD). However, the cause of IVIG resistance in KD remains unknown. miR-221-3p has been confirmed involved in cardiovascular diseases and rheumatoid arthritis. The purpose of this study was to investigate the association between miR-221-3p and IVIG resistance in children with KD.Methods55 KD patients and 29 healthy controls (HCs) were enrolled in this study. KD patients were divided into group of sensitive to IVIG (IVIG-response, n=42) and group of resistant to IVIG (IVIG-resistance, n=13). Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were used to detect the levels of miR-221-3p.ResultsCompared with the HCs group, miR-221-3p were significantly increased in the KD group (p < 0.05), and the IVIG-resistance group had higher levels of miR-221-3p than those in the IVIG-response group (p < 0.05). CRP (C-reactive protein), PCT (procalcitonin), NLR (neutrophil-lymphocyte ratio) were positively correlated with miR-221-3p in KD patients. In addition, the group of IVIG resistance had a higher level of Kobayashi Score (p <0.001). The receiver operating characteristic (ROC) curve showed that miR-221-3p had a better value for diagnosis IVIG resistance in children with KD than Kobayashi Score and the combination of both with the AUC of 0.811 (95% CI, 0.672-0.951), 0.793 (95% CI, 0.618-0.968) and 0.797 (95% CI, 0.619-0.974), respectively.ConclusionsmiR-221-3p might be involved in the pathogenesis of KD and IVIG resistance and miR-221-3p can be used as a new potential biomarker to predict of IVIG resistance in children with KD.