bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative analysis of hillshed geomorphology and critical zone function: Raising the hillshed to watershed status
Authors: Brecheisen Zachary S. , Richter Daniel D. , Moon Seulgi , Halpin Patrick N. 
Published: December 2021

Abstract
Landscapes are frequently delineated by nested watersheds and river networks ranked via stream orders. Landscapes have only recently been delineated by their interfluves and ridge networks, and ordered based on their ridge connectivity. There are, however, few studies that have quantitatively investigated the connections between interfluve networks and landscape morphology and environmental processes. Here, we ordered hillsheds using methods complementary to traditional watersheds, via a hierarchical ordering of interfluves, and we defined hillsheds to be landscape surfaces from which soil is shed by soil creep or any type of hillslope transport. With this approach, we demonstrated that hillsheds are most useful for analyses of landscape structure and processes. We ordered interfluve networks at the Calhoun Critical Zone Observatory (CZO), a North American Piedmont landscape, and demonstrated how interfluve networks and associated hillsheds are related to landscape geomorphology and processes of land management and land-use history, accelerated agricultural gully erosion, and bedrock weathering depth (i.e., regolith depth). Interfluve networks were ordered with an approach directly analogous to that first proposed for ordering streams and rivers by Robert Horton in the GSA Bulletin in 1945. At the Calhoun CZO, low-order hillsheds are numerous and dominate most of the observatory's ~190 km2 area. Low-order hillsheds are relatively narrow with small individual areas, they have relatively steep slopes with high curvature, and they are relatively low in elevation. In contrast, high-order hillsheds are few, large in individual area, and relatively level at high elevation. Cultivation was historically abandoned by farmers on severely eroding low-order hillsheds, and in fact agriculture continues today only on high-order hillsheds. Low-order hillsheds have an order of magnitude greater intensity of gullying across the Calhoun CZO landscape than high-order hillsheds. In addition, although modeled regolith depth appears to be similar across hillshed orders on average, both maximum modeled regolith depth and spatial depth variability decrease as hillshed order increases. Land management, geomorphology, pedology, and studies of land-use change can benefit from this new approach pairing landscape structure and analyses.
Distribution of Microfossils in the Vendian Deposits of the Orsha Depression of the East European Platform, Belarus
Authors: Golubkova E. Yu. , Kuzmenkova O. F. , Kushim E. A. , Laptsevich A. G. , Mankievič S. S. , Plotkina Yu. V. 
Published: December 2021

Abstract—The complete sections of the Lower and Upper Vendian of the East European Platform were opened in the boreholes of Belarus. This allows us to consider this region as a stratotype area. In order to update the paleontological characteristics of the Vendian, organic-walled microfossils from the Bogushevsk-1, Bogushevsk-2 (Liozno), and Lepel-1 reference boreholes drilled in the north of the Orsha Depression were studied. The transitive assemblage I with Leiosphaeridia minutissima–Leiosphaeridia tenuissima was recognized in the Lower Vendian Liozno Formation of the Volyn Series and the Upper Vendian Kotlin Formation. The Redkino microfossil assemblages were identified at three stratigraphic levels in the Nizy, Selyava, and Chernitsa formations: assemblage II with Morania zinkovi, assemblage III with Morania zinkovi–Tynnia precambrica, and assemblage IV withMoraniazinkovi–Tynnia precambrica–Striatella coriacea, respectively. The Kotlin assemblage V with Vendotaenia antiqua–Primoflagella speciosa was distinguished in the upper part of the Kotlin Formation (Bogushevsk-1 borehole). On the basis of the taxonomic composition, assemblages III and IV are correlated with the first Redkino biota of the Starorusskaya Formation; assemblage V is correlated with the third Kotlin biota of the Vasileostrovskaya Formation of the northwestern part of Russia. Our data show a high biostratigraphic potential of organic-walled microfossils, which should be used to substantiate regional stratigraphic units of the Upper Vendian in the updated stratigraphic scheme of the East European Platform.
Ustekinumab is effective for perianal fistulising Crohn's disease: a real-world experience and systematic review with meta-analysis
Authors: Godoy Brewer Gala M , Salem George , Afzal Muhammad A , Limketkai Berkeley N , Haq Zadid , Tajamal Maryam , Melia Joanna , Lazarev Mark , Selaru Florin M , Parian Alyssa M. 
Published: December 2021

BackgroundPerianal Crohn’s disease (pCD) is a debilitating complication affecting up to 30% of Crohn’s disease (CD) population, leading to increased morbidity, mortality and decreased quality of life. Despite the growing armamentarium of medications for luminal CD, their efficacy in pCD remains poorly studied.AimTo determine the efficacy of ustekinumab, a biologic approved for luminal CD, in pCD through a retrospective cohort study and systematic review.MethodsA retrospective cohort study on patients with CD with active perianal fistulae treated with ustekinumab from September 2013 to August 2019 was performed to determine perianal fistula response and remission at 6 and 12 months after ustekinumab induction. A systematic review was performed to further establish rates of fistula response and remission with ustekinumab.ResultsAt 6 months, 48.1% (13/27) patients achieved fistula response with none achieving fistula remission on provider exam, and 59.3% (16/27) achieved patient-reported symptomatic improvement with 3.7% (1/27) achieving symptomatic remission. At 1 year, on provider exam, 55.6% (5/9) had fistula response with none achieving fistula remission, and 100% (9/9) had symptomatic improvement with 22.2% (2/9) achieving symptomatic remission. There were no major safety signals during 1-year follow-up. The systematic review of 25 studies found 44% (92/209) of patients with active perianal fistulas had a clinical response within 6 months of follow-up, and 53.9% (85/152) of patients with 12 months of follow-up achieved clinical response.ConclusionUstekinumab presents a safe and effective therapy for treatment of pCD. Prospective, randomised trials are needed to further elucidate long-term efficacy of ustekinumab for pCD.
Incidence rates of systemic lupus erythematosus in the USA: estimates from a meta-analysis of the Centers for Disease Control and Prevention national lupus registries
Authors: Izmirly Peter M , Ferucci Elizabeth D , Somers Emily C , Wang Lu , Lim S Sam , Drenkard Cristina , Dall'Era Maria , McCune W Joseph , Gordon Caroline , Helmick Charles , Parton Hilary 
Published: December 2021

ObjectiveTo estimate the annual incidence rate of SLE in the USA.MethodsA meta-analysis used sex/race/ethnicity-specific data spanning 2002–2009 from the Centers for Disease Control and Prevention network of four population-based state registries to estimate the incidence rates. SLE was defined as fulfilling the 1997 revised American College of Rheumatology classification criteria. Given heterogeneity across sites, a random effects model was employed. Applying sex/race/ethnicity-stratified rates, including data from the Indian Health Service registry, to the 2018 US Census population generated estimates of newly diagnosed SLE cases.ResultsThe pooled incidence rate per 100 000 person-years was 5.1 (95% CI 4.6 to 5.6), higher in females than in males (8.7 vs 1.2), and highest among black females (15.9), followed by Asian/Pacific Islander (7.6), Hispanic (6.8) and white (5.7) females. Male incidence was highest in black males (2.4), followed by Hispanic (0.9), white (0.8) and Asian/Pacific Islander (0.4) males. The American Indian/Alaska Native population had the second highest race-specific SLE estimates for females (10.4 per 100 000) and highest for males (3.8 per 100 000). In 2018, an estimated 14 263 persons (95% CI 11 563 to 17 735) were newly diagnosed with SLE in the USA.ConclusionsA network of population-based SLE registries provided estimates of SLE incidence rates and numbers diagnosed in the USA.
British doctors’ work–life balance and home-life satisfaction: a cross-sectional study
Authors: Parida Swati , Aamir Abdullah , Alom Jahangir , Rufai Tania A , Rufai Sohaib R 
Published: December 2021

Abstract

Purpose
To assess British doctors’ work–life balance, home-life satisfaction and associated barriers.

Study design
We designed an online survey using Google Forms and distributed this via a closed social media group with 7031 members, exclusively run for British doctors. No identifiable data were collected and all respondents provided consent for their responses to be used anonymously. The questions covered demographic data followed by exploration of work–life balance and home-life satisfaction across a broad range of domains, including barriers thereto. Thematic analysis was performed for free-text responses.

Results
417 doctors completed the survey (response rate: 6%, typical for online surveys). Only 26% reported a satisfactory work–life balance; 70% of all respondents reported their work negatively affected their relationships and 87% reported their work negatively affected their hobbies. A significant proportion of respondents reported delaying major life events due to their working patterns: 52% delaying buying a home, 40% delaying marriage and 64% delaying having children. Female doctors were most likely to enter less-than-full-time working or leave their specialty. Thematic analysis revealed seven key themes from free-text responses: unsocial working, rota issues, training issues, less-than-full-time working, location, leave and childcare.

Conclusions
This study highlights the barriers to work–life balance and home-life satisfaction among British doctors, including strains on relationships and hobbies, leading to many doctors delaying certain milestones or opting to leave their training position altogether. It is imperative to address these issues to improve the well-being of British doctors and improve retention of the current workforce.
Impacts of COVID-19 on sexual behaviour in Britain: findings from a large, quasi-representative survey (Natsal-COVID)
Authors: Mercer Catherine H , Clifton Soazig , Riddell Julie , Tanton Clare , Freeman Lily , Copas Andrew J , Dema Emily , Bosó Pérez Raquel , Gibbs Jo , Macdowall Wendy , Menezes Dee , Ridge Mary-Clare , Bonell Chris , Sonnenberg Pam , Field Nigel , Mitchell Kirstin R 
Published: December 2021

ObjectivesPhysical restrictions imposed to combat COVID-19 dramatically altered sexual lifestyles but the specific impacts on sexual behaviour are still emerging. We investigated physical and virtual sexual activities, sexual frequency and satisfaction in the 4 months following lockdown in Britain in March 2020 and compared with pre-lockdown.MethodsWeighted analyses of web panel survey data collected July/August 2020 from a quota-based sample of 6654 people aged 18–59 years in Britain. Multivariable regression took account of participants’ opportunity for partnered sex, gender and age, to examine their independent associations with perceived changes in sexual frequency and satisfaction.ResultsMost participants (86.7%) reported some form of sex following lockdown with physical activities more commonly reported than virtual activities (83.7% vs 52.6%). Altogether, 63.2% reported sex with someone (‘partnered sex’) since lockdown, three-quarters of whom were in steady cohabiting relationships. With decreasing relationship formality, partnered sex was less frequently reported, while masturbation, sex toy use and virtual activities were more frequently reported. Around half of all participants perceived no change in partnered sex frequency compared with the 3 months pre-lockdown, but this was only one-third among those not cohabiting, who were more likely to report increases in non-partnered activities than those cohabiting. Two-thirds of participants perceived no change in sexual satisfaction; declines were more common among those not cohabiting. Relationship informality and younger age were independently associated with perceiving change, often declines, in sexual frequency and satisfaction.ConclusionsOur quasi-representative study of the British population found a substantial minority reported significant shifts in sexual repertoires, frequency and satisfaction following the introduction of COVID-19 restrictions. However, these negative changes were perceived by some more than others; predominantly those not cohabiting and the young. As these groups are most likely to experience adverse sexual health, it is important to monitor behaviour as restrictions ease to understand the longer term consequences, including for health services.
Classifying the comprehensiveness of flavoured tobacco sales restrictions: development and application of a tool to examine US state and local tobacco policies
Authors: Donovan Emily , Folger Shanell , Akbar Maham , Schillo Barbara 
Published: December 2021

ObjectivesComprehensive tobacco control policies with minimal exemptions can reduce tobacco use and sales. Many states and localities have adopted flavoured tobacco product (FTP) sales restrictions. This study describes the development and application of a schema to characterise the comprehensiveness of these FTP sales restrictions.DesignWe coded state and local FTP sales restrictions enacted June 2007–March 2021 for retailer, tobacco product, and flavour inclusions and exemptions. Guided by FTP literature, legal resources and meetings with FTP policy experts, we developed a six-level classification scheme to characterise coded FTP policies from least to most comprehensive. We present descriptive statistics of FTP policy features and comprehensiveness.ResultsAs of 31 March 2021, 7 state-level and 327 local-level FTP sales restrictions were enacted in the USA. Most state-level policies (71.4%) were categorised in the second lowest comprehensiveness category; local policies most commonly fell within the lowest (48.9%) or highest (26.0%) comprehensiveness categories. Across jurisdictions, adult-only retailers were most frequently exempted from the FTP sales restrictions (state: n=1, 14.3%; local: n=184, 56.3%); and most jurisdictions included electronic cigarettes (e-cigarettes) as a banned product (state: n=6, 87.5%; local: n=327, 100%). While just over half of state (n=4, 57.1%) and local (n=169, 51.7%) sales restrictions included menthol e-cigarettes, most excluded menthol cigarettes and/or menthol smokeless tobacco.ConclusionsComprehensiveness of FTP sales restrictions in the USA varies widely. Current and future FTP policies would be strengthened by including all flavours and all tobacco products—particularly menthol cigarettes—and by avoiding exemptions for certain retailers, particularly adult-only retailers.
The new “MUON G-2” result and supersymmetry
Authors: Chakraborti Manimala , Heinemeyer Sven , Saha Ipsita 
Published: December 2021

AbstractThe electroweak (EW) sector of the Minimal Supersymmetric Standard Model (MSSM), with the lightest neutralino as Dark Matter (DM) candidate, can account for a variety of experimental data. This includes the DM content of the universe, DM direct detection limits, EW SUSY searches at the LHC and in particular the so far persistent $$3-4\,\sigma $$

3
-
4

σ

discrepancy between the experimental result for the anomalous magnetic moment of the muon, $$(g-2)_\mu $$

(
g
-
2
)

μ

, and its Standard Model (SM) prediction. The recently published “MUON G-2” result is within $${0.8}\,\sigma $$

0.8

σ

in agreement with the older BNL result on $$(g-2)_\mu $$

(
g
-
2
)

μ

. The combination of the two results was given as $$a_\mu ^{\mathrm{exp}} = (11 659 {206.1}\pm {4.1}) \times 10^{-10}$$

a
μ
exp

=

(
11659

206.1

±

4.1

)

×

10

-
10

, yielding a new deviation from the SM prediction of $$\Delta a_\mu = ({25.1}\pm {5.9}) \times 10^{-10}$$

Δ

a
μ

=

(

25.1

±

5.9

)

×

10

-
10

, corresponding to $${4.2}\,\sigma $$

4.2

σ

. Using this improved bound we update the results presented in Chakraborti et al. (Eur Phys J C 80(10):984, 2020) and set new upper limits on the allowed parameters space of the EW sector of the MSSM. We find that with the new $$(g-2)_\mu $$

(
g
-
2
)

μ

result the upper limits on the (next-to-) lightest SUSY particle are in the same ballpark as previously, yielding updated upper limits on these masses of $$\sim 750 \,\, \mathrm {GeV}$$

∼
750

GeV

. In this way, a clear target is confirmed for future (HL-)LHC EW searches, as well as for future high-energy $$e^+e^-$$

e
+

e
-

colliders, such as the ILC or CLIC.
Development of Refractive Parameters in 3- to 6-Year-Old Children and Its Application in Myopia Prediction and Intervention Guidance
Authors: Zhang Ya , Su Ming , Liu Hua , Song Yanxia , Liu Jing , Sun Huihui , Wu Xueya , Yang Xiaoge , Qi Liqin , Du Feifan , Liu Lili , Chen Lu , Huang Jing , Guo Xiting , Yang Zhongnan , Yang Xueping 
Published: December 2021

Objective. To investigate refractive development and prevalence of myopia in children aged 3-6 years in Hebei Province, China, and to explore the developmental law of refraction, so as to clinically guide the prediction and intervention of myopia. Methods. In May 2019, a total of 6120 people were inspected in 68 kindergartens in 11 cities in Hebei Province. Child refractive refraction was checked under noncycloplegia using a handheld binocular vision screener (SW-800, SUOER, Tianjin, China). Axial length (AL) and corneal radius of curvature (CR) were measured using an ocular biometry (IOLMaster 500, Carl Zeiss, Germany). Myopia was defined as spherical equivalent

SE

≤
−
0.75

D

. Results. A total of 5506 children aged 3-6 years met the criteria and were included in the statistical analysis. The prevalence of myopia was 3.49% (1.93% at age 3, 2.90% at age 4, 3.78% at age 5, and 3.88% at age 6). Overall, the mean SE was

+
0.67
±
1.05

D

(

+
0.81
±
1.00

D

at age 3,

+
0.79
±
1.05

D

at age 4,

+
0.67
±
1.08

D

at age 5, and

+
0.13
±
1.01

D

at age 6); the mean CR was

7.76
±
0.26

mm

(

7.78
±
0.26

mm

at age3,

7.75
±
0.25

mm

at age 4,

7.77
±
0.26

mm

at age 5, and

7.76
±
0.25

mm

at age 6); the mean AL was

22.31
±
0.73

mm

(

21.98
±
0.63

mm

at age 3,

22.12
±
0.69

mm

at age 4,

22.34
±
0.73

mm

at age 5, and

22.49
±
0.73

mm

at age 6). Conclusions. Prevalence of myopia increases with age in children aged 3-6 years in Hebei, China. With the increase of age, CR is basically stable, and AL increases gradually. AL/CR, which is closely related to SE, can be used as an indicator to predict myopia and guide clinical work.
BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes
Authors: Schaefer Eva J. , Wang Helen C. , Karp Hannah Q. , Meyer Clifford A. , Cejas Paloma , Gearhart Micah D. , Adelman Emmalee R. , Fares Iman , Apffel Annie , Lim Klothilda , Xie Yingtian , Gibson Christopher J. , Schenone Monica , Murdock H. Moses , Wang Eunice S. , Gondek Lukasz P. , Carroll Martin P. , Vedula Rahul S. , Winer Eric S. , Garcia Jacqueline S. , Stone Richard M. , Luskin Marlise R. , Carr Steven A. , Long Henry W. , Bardwell Vivian J. , Figueroa Maria E. , Lindsley R. Coleman 
Published: December 2021

Abstract

Polycomb repressive epigenetic complexes are recurrently dysregulated in cancer. Unlike polycomb repressive complex 2 (PRC2), the role of PRC1 in oncogenesis and therapy resistance is not well-defined. Here, we demonstrate that highly recurrent mutations of the PRC1 subunits BCOR and BCORL1 in leukemia disrupt assembly of a noncanonical PRC1.1 complex, thereby selectively unlinking the RING-PCGF enzymatic core from the chromatin-targeting auxiliary subcomplex. As a result, BCOR-mutated PRC1.1 is localized to chromatin but lacks repressive activity, leading to epigenetic reprogramming and transcriptional activation at target loci. We define a set of functional targets that drive aberrant oncogenic signaling programs in PRC1.1-mutated cells and primary patient samples. Activation of these PRC1.1 targets in BCOR-mutated cells confers acquired resistance to treatment while sensitizing to targeted kinase inhibition. Our study thus reveals a novel epigenetic mechanism that explains PRC1.1 tumor-suppressive activity and identifies a therapeutic strategy in PRC1.1-mutated cancer.

Significance:
We demonstrate that BCOR and BCORL1 mutations in leukemia unlink PRC1.1 repressive function from target genes, resulting in epigenetic reprogramming and activation of aberrant cell signaling programs that mediate treatment resistance. Our study provides mechanistic insights into the pathogenesis of PRC1.1-mutated leukemia that inform novel therapeutic approaches.
This article is highlighted in the In This Issue feature, p. 85
Metal Quivers from Western Asia
Authors: Castelluccia Manuel 
Published: December 2021

Abstract
This paper presents a review of metal quivers, which belong to a category of metal objects found in Iron Age archaeological contexts in the Ancient Near East, especially in the variegate cultures living in the mountainous highlands bordering Mesopotamia. Each cultural sphere is considered separately, focusing on material brought to light during archaeological excavations. An analysis of different traditions allows comparison of these artifacts in order to detect evidence of contacts and reciprocal influences between different cultural regions, which strongly interacted during the first half of the Iron Age.
Inquisitor as Physician: Friars, Inquisitors, Women, and Medical Knowledge in Early Colonial New Spain (1530–1650)
Authors: Holler Jacqueline 
Published: December 2021

Abstract
New Spain was the site not only of one of the largest-scale missionary enterprises in Christian history, but also of a prolonged encounter among diverse medical traditions of Mesoamerican, African, and European origin in which male missionaries were central. Given the paucity of licensed physicians in the colony, religious involvement in medical practice remained significant throughout the colonial period. This paper considers the confluence of religion and medicine in the encounters that friars and inquisitors had with women, arguing that in these encounters, missionaries and inquisitors participated in the translation, circulation, and creation of medical knowledge and positioned themselves as both theological and medical authorities, as proponents and translators of Galenic medical theory, and as “confessor-physicians” rather than “confessor-judges.” Women thus played a crucial interlocutory role in the articulation of a colonial religio-medical regime whose primary framers were not physicians, but clergymen.
The New Religious Political Right in Neo-Apartheid South Africa
Authors: Dube Siphiwe Ignatius 
Published: December 2021

Abstract
This article argues that, in similar ways that scholars such as Kaye (1987) and Apple (1990) have respectively demonstrated how post 1970s America and Britain fused the neo-liberal discourse of free markets with the neo-conservative Christian discourse of moral rightness to found a New Right, we can apply this analytical model in post-apartheid/neo-apartheid South Africa. The aim of this analytical comparison is to support the broad claim that the article makes about the rise of the New Right in contemporary South Africa as directly related to the fusion of neo-Pentecostal Christianity with neoliberal economics in very salient ways. Using discourse analysis, the article demonstrates how the New Right in South Africa also draws from the language of crisis to justify a response that brings together the interlocking of race, religion, and neoliberalism. The paper’s main argument is that, a different type of New Right is emerging in current day South Africa, one that is not simply the purview of whitenationalism, but has main appeal also within the black middle-class.