bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Ulinastatin on Postoperative Renal Function in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass: a Prospective Cohort Study
Authors: Lv Hong , Lv Huanran , Fei Yuda , Li Qian , zhang Peng , Cao Liang , Li LiHuan , Shi Jia 
Published: November 2021

Abstract
Background: Ulinastatin is a serine protease inhibitor with anti-inflammatory effects. Evidence for the effects of ulinastatin on renal outcomes remains sparse in patients receiving cardiac surgery with cardiopulmonary bypass (CPB).Methods: This prospective cohort study evaluated 413 patients aged 18–70 years who underwent cardiac surgery with CPB, from Aug 2008 to Jul 2019 in Fuwai Hospital, Beijing ,China. The ulinastatin group included 135 patients who received intravenous ulinastatin (1×106 U) after induction of anesthesia. The remaining 278 patients without ulinastatin served as the control group. The primary outcome was the rate of new-onset postoperative acute kidney injury (AKI). The secondary outcome was renal replacement therapy(RRT). Serum creatinine, plasma NGAL, and serum IL-6 levels were evaluated and the CSANGAL Score was calculated. In addition, in-hospital mortality, morbidity, adverse outcomes and 10-year follow-up the survival rate was analyzed.Results: Rate of new-onset AKI was significantly lower in the ulinastatin group than in the control group (20.00% vs. 32.40%, p=0.009). There was no significant difference of RRT between the two groups (0.00% vs. 2.16%, p=0.09). In-hospital mortality, morbidity, and adverse outcomes were comparable between the two groups except for a significantly lower incidence of respiratory failure in the ulinastatin group compared with the control group (0.76% vs. 5.40%, p=0.02). The 10-year follow-up survival rates did not differ significantly between the two groups.Conclusions: Ulinastatin significantly reduced postope rative AKI and respiratory failure in patients receiving cardiac surgery with CPB. But ulinastatin did not reduce ICU and hospital stay and mortality.Clinical trial registration: NCT01060189
Analysis of Chromosome 3P Genes Associated With Clinical Staging of Small Cell Lung Cancer and Prediction of Targeted Drugs
Authors: Ma Chun-Xu , Zhao Ji-Hua , Wu Ying , Wang Jun , Wang Hao 
Published: November 2021

Abstract
BackgroundNowadays, the diagnosis of small-cell lung cancer (SCLC) remains a great challenge. Changes in the chromosome 3p (chr3) gene are usually observed in the pathogenesis of lung cancer, which seems to imply that these chr3 genes may be a diagnostic marker in the early stage of SCLC. MethodsBased on Differentially expressed genes (DEGs) screening analysis, Weighted gene co-expression network analysis, and Receiver operating characteristic (ROC) curves, this study explored the diagnostic value of the chr3 gene obtained from the University of California Santa Cruz Genome Browser Database in SCLC. Meanwhile, quantitative real-time Polymerase Chain Reaction (qRT-PCR) was used to reveal the expression patterns of diagnostic biomarkers in Human pulmonary alveolar epithelial cells and the SCLC cell line NCI-H146. The potential pathways involved in the diagnostic biomarkers were investigated by a single-gene Gene Set Enrichment Analysis (GSEA). Furthermore, drugs regulating the expression levels of diagnostic biomarkers were predicted by the Comparative Toxicogenomics Database (CTD).ResultsWe identified a total of 33 differentially expressed chr3 (DE-chr3) genes and 1156 hub genes associated with clinical features of SCLC, and functional enrichment analysis showed that all of these genes were significantly enriched in the cell cycle terms. Ultimately, the area under curve of the ROC curve demonstrated that the overlapping genes of the DE-chr3 genes and the hub genes, CDC25A, FYCO1, and RFTN1, were relatively accurate in distinguishing normal from SCLC samples, which were considered to be diagnostic biomarkers. CDC25A was overexpressed in SCLC samples, while FYCO1 and RFTN1 were highly expressed in normal samples, as evidenced by qRT-PCR results. Single-gene GSEA showed that diagnostic biomarkers were significantly associated with cell cycle, ABC transporter, immune cell differentiation, immune response, and multiple respiratory disease pathways. Further, a total of 141 drugs were predicted by the CTD to modulate the expression of diagnostic biomarkers, of which 8 drugs were the shared drugs for 3 diagnostic biomarkers.ConclusionsThis project provided 3 novel and powerful diagnostic biomarkers for SCLC based on the chr3 genes. Meanwhile, a guideline for the development and selection of drugs for clinical treatment based on diagnostic biomarkers was also included.
Hypothetical Failure of the Khassa Chai Dam and Flood Risk Analysis for Kirkuk, Iraq
Authors: Abdulrahman Kawa Zaidan , Faris Mariwan Redha , Ibrahim Hekmat , Yousif Omed , Ghafoor Alan , Othman Luqman , Karakouzian Moses 
Published: November 2021

Abstract
Many of Iraqi's high-hazard dams lack an Emergency Action Plan, which should include a flood inundation map to show which downstream areas would be flooded if the dams were to fail. This article presents the results of the simulation of a hypothetical 2D dam break for the 58 m high Khassa Chai dam in Kirkuk, Iraq, using HEC-RAS 2D 5.0.7 software. The Khassa Chai dam is situated 7.4 kilometers north of Kirkuk. The simulations revealed that the dam-break flood will affect eight major bridges and the majority of Kirkuk city's metropolitan neighborhoods. Within an hour, the floodwaters will reach the city's center. The flood hazard map revealed that if the Khassa Chai dam fails, many people, vehicles, and structures will be at danger. The findings of this paper can be used to identify evacuation routes and refuge sites as well as build suitable warning systems in order to limit the risk for fatalities if the Khassa Chai dam fails. Moreover, as the effect of modelling bridges downstream of failed dams has not been explored yet, to the knowledge of the authors, eight bridges have been modeled. It was concluded that ignoring bridges in such a large dam break model will not affect the results significantly, which saves the time of data collection and model development.
Experimental Study on Sdccag3 Regulating Osteogenesis and Adipogenic Differentiation of Rats Bone Marrow Mesenchymal Stem Cells
Authors: Yuan Mengqi , Huo Fenglei , Ren Huiping , Guo Qiushuang , Lan Jing 
Published: November 2021

Abstract
Background

Bone marrow mesenchymal stem cells have a metabolic balance between osteogenic and adipogenic differentiation. Sdccag3 is differentially expressed in hyperlipidemia rats, and it can be beneficial to the osteogenesis disorder caused by dyslipidemia, but the pathway mechanism and its influence on the differentiation have not been studied.
Methods

Here, we designed RT-PCR and Western Blot to determine the expression of Osteogenic and lipid gene, including ALP, Runx2, PPARγ FABP4 and so on, and then we performed microarray to evaluate the bone formation, calculate BV/TV. Simultaneously, we detected mRNA from the hyperlipidemia rat model we established to find the specific pathway mechanism.
Results

In this experiment, we found that high fat environment influences BMSCs differentiation. Sdccag3 overexpression upregulates the osteogenic differentiation of BMSCs and increased new bone formation.
Conclusion

Therefore, our findings show that Sdccag3 regulates osteogenesis and adipogenic differentiation of BMSCs.
Is The Healthy Eating Index-2015 Associated With Rheumatoid Arthritis?
Authors: Nayebi Atiyeh , Soleimani Davood , Mostafaei Shayan , Elahi Negin , Elahi Homayoun , Mahmoudi Mahdi , Nachvak Seyed Mostafa , Bagheri Amir 
Published: November 2021

Abstract
Objective: Healthy Eating Index-2015 (HEI-2015) is a multidimensional criterion of diet quality utilized to evaluate how well people’s dietary behaviors align with major recommendations of the 2015–2020 Dietary Guidelines for Americans. We aim to investigate the association between the diet quality and Rheumatoid arthritis (RA) activity.Design: Cross-sectional studySetting: This study was done on 184 patients with RA in rheumatology clinic in Kermanshah city, Iran, in 2020. RA was diagnosed according to the criteria of the 2010 American College of Rheumatology/ European League against Rheumatism. The overall quality diet was extracted from a validated 168-item food frequency questioner (FFQ) to calculate the HEI-2015 score. RA disease activity was assessed using Disease Activity Score 28 (DAS28) scores. One-way ANOVA and ANCOVA were done to find the associations.Participants: RA patientsResults: Individuals in the highest HEI-2015 quartile had a lower mean Erythrocyte Sedimentation Rate (ESR) than those in the lowest quartiles of the HEI scores (P-value: 0.014). A linear trend towards decreasing waist circumference in patients was observed with increasing quartiles of the HEI-2015 scores (P-value= 0.005). After controlling for all potential confounders, patients in the highest HEI-2015 quartile had the lowest DAS28 scores than those in the lowest quartile of the HEI-2015 scores (Q1= 3.65; 95% CI= 3.29 – 4.02 vs. Q4= 2.35; 95% CI= 1.94 - 2.67; P-value<0.001).Conclusion: Our results indicated that following a high diet quality might be one of the therapeutic strategies to control or reduce the disease activity in RA patients.
Distinct Acute Unilateral Fibrinous Anterior Uveitis After Zoledronic Acid Infusion: A Case Report
Authors: Kaiser Klemens Paul , Turgut Ferhat , Becker Matthias Dieter , Dingerkus Vita Louisa Sophie 
Published: November 2021

Abstract
Purpose: To report a case of a distinct acute unilateral fibrinous anterior uveitis after zoledronic acid infusion.Methods: Case Report.Results: A 68-year-old woman presented with a burning, itching and reddened right eye with visual deterioration for about five days. She had received her first intravenous infusion of zoledronic acid the day before the onset of the symptoms. Her best-corrected visual acuity was 6/24. She was mainly treated with topical corticosteroids (prednisolone 1% eye drops and subconjunctival dexamethasone) and scopolamine 0.25 %. This treatment resulted in a significant improvement of the findings and symptoms within a few days.Conclusions: It is crucial that patients receiving bisphosphonates are accurately informed about the possibility of ocular inflammation, other inflammatory side effects and their symptoms to ensure early treatment.
Chained Multimediator Model of Sexual Orientation Disclosure, Sexual Minority Stigma, Sexual Minority Identity, Social Support, and Resilience among YMSMs
Authors: Tan Sumin , Cen Ping , Fang Ting , Yang Xing , Zhang Yun , Zhu Jiawen , Huang Haimei , Wang Min , Jiang Li , Mo Jieling , Ning Chuanyi 
Published: November 2021

Abstract
Introduction: This study aimed to investigate sexual orientation disclosure and mental health among young men who have sex with men (YMSMs). To this end, we constructed a chained multimediator model of sexual minority stigma, sexual minority identity, social support, and resilience, with the moderator of sexual orientation disclosure. Methods: We conducted a cross-sectional survey of 345 YMSMs in Nanning, China. Univariate analysis was used to evaluate factors associated with sexual orientation disclosure. Sexual minority stigma was used to predict identity, with social support as the step 1 mediator and resilience as the step 2 mediator. Sexual minority identity was analyzed using a chained moderated mediation model; sexual orientation disclosure was included as a moderator in all models to control its confounding effect. Results: The average age of YMSMs was 20.0 ± 1.3 years. Univariate analysis indicated that YMSMs who disclosed sexual orientation may have experienced less stigma (15.49 ± 3.02 vs 16.21 ± 2.74), obtained more social support (65.98 ± 11.18 vs 63.19 ± 11.13), had strong psychological resilience (37.40 ± 8.57 vs 35.39 ± 7.73), and had a more positive self-identity (104.12 ± 21.10 vs 95.35 ± 16.67); differences between subgroups were statistically significant (p < 0.05). Sexual minority stigma, perceived stigma, and enacted stigma were significantly associated with social support and resilience. The association between sexual minority stigma and sexual minority identity was significantly mediated by social support (indirect effect [95% CI] = −3.307 [−4.782, −1.907]). Resilience significantly mediated the same association for identity (−2.544 [−4.052, −1.114]). The chained relationship from sexual minority stigma to social support, resilience, and identity was also significant, with an indirect effect of −0.404 [−0.621, −0.249]. Conclusion: Among YMSMs in China, sexual minority stigma affects sexual minority identity through social support and resilience. Given the psychological effects of stigma, social support and resilience must be considered to better promote positive self-identity and mental health among YMSMs.
Ultrasonographic Assessment of Entheseal Sites of Upper and Lower Extremities in Hemodialysis Patients using Madrid Sonography Enthesitis Index
Authors: Sabry Reham , Tharwat Samar , Nassar Mohammed Kamal , Eltoraby Ehab E 
Published: November 2021

Abstract
Background Musculoskeletal (MSK) complications are one of the most common health concerns that impact individuals on maintenance hemodialysis (HD). However, little is known about the entheseal involvement in HD patients. The aim of this study was to assess the prevalence and distribution of entheseal ultrasonographic (US) alterations in HD patients and to evaluate the association between US findings and both clinical and laboratory data.Methods: This study was conducted on 41 HD and 23 sex- and age- matched controls. All HD patients and healthy controls were evaluated clinically to detect any clinical evidence of enthesopathy. Six entheses sites were scanned bilaterally using grey scale (GS) and power Doppler (PD) ultrasonography (US) and were scored using Madrid Sonography Enthesitis Index (MASEI) scoring system. Results:Clinical examination revealed at least one sign suggestive of enthesopathy in 69 (14.02) of 492 entheses in 41 HD patients. HD patients had statistically significant higher scores of stuctural tendon abnormalities (p<0.001), enthesis thickening (p<0.001), bone erosions (p<0.001) and calcification (p=0.037) than healthy controls. Total MASEI score was higher in HD patients than healthy controls (median ;18 vs 8, p<0.001), also, MASEI-inflammatory (median ;11 vs 3, p<0.001) and damage scores (median ;6 vs 0, p<0.001). There was a statistically significant positive association between total MASEI score and both age (p=0.032) and duration of HD (p=0.037). Duration of HD was predictive for both MASEI-damage component (p=0.004) and total MASEI score (p=0.014).Conclusions: There is a high prevalence of asymptomatic enthesopathy in HD patients. The burden of entheseal US alterations is much higher in HD patients than in healthy subjects. US can be helpful in the early detection of entheseal abnormalities. The duration of HD is the most significant predictor of enthesopathy in HD patients.
Characterisation of the Function of a SINE-VNTR-Alu Retrotransposon to Modulate Isoform Expression at the MAPT Locus
Authors: Fröhlich Alexander , Pfaff Abigail L. , Bubb Vivien J. , Koks Sulev , Quinn John P. 
Published: November 2021

Abstract
Background: SINE-VNTR-Alu retrotransposons represent one class of transposable elements which contribute to the regulation and evolution of the primate genome and have the potential to be involved in genetic instability and disease progression. However, these polymorphic elements have not been extensively analysed when addressing the missing heritability of neurodegenerative diseases, including Parkinson´s disease (PD) and amyotrophic lateral sclerosis (ALS). SVA_67, a retrotransposon insertion polymorphism, is located in a 1.8 Mb region of high linkage disequilibrium, called the MAPT locus, which is known to contribute to increased risk of developing PD, frontotemporal dementia and other tauopathies. This study was conducted to investigate the role of SVA_67 in directing differential gene expression at this locus by characterising the impact of SVA_67 allele dosage on isoform expression of several genes in the MAPT locus.Methods:In this study, transcriptomic data from both the Parkinson’s Progression Markers Initiative and New York Genome Center Consortium Target ALS cohort were used. The Parkinson’s data was from gene expression in the blood and the ALS data from a variety of central nervous system (CNS) regions. The association of three different genotypes (AA, PA, PP) based on the presence (P) or absence (A) of SVA_67 was analysed. The unpaired Wilcoxon test was used to compare two independent groups of samples and to demonstrate statistical significance.Results: Using two different datasets for analysis, we could demonstrate that SVA_67 presence or absence was significantly associated with 1) changes in expression of multiple genes at this locus and 2) both differential isoform and tissue specific expression of these genes.Conclusions:This study highlights the importance of addressing SVA polymorphism in disease genetics to gain insight into a better understanding of the role of these regulatory domains to a variety of neurodegenerative diseases. Therefore, this study underlines an additional type of variation to be considered at the MAPT locus and an added layer of complexity when analysing the missing heritability of neurodegenerative diseases.
Design And Numerical Analysis of Morphing Airfoil With Corrugated Geometry In The Application MAV’s
Authors: Kumar Kishore , Nithisha Kanneti , Vivek Manvi , Simran Mohammad Saniya , Ra Ravi Sri 
Published: November 2021

Abstract
The main objective of the work is to enhance the aerodynamic performance during takeoff and cruise by using newly corrugated airfoil of MAV’s by Morphing it at the trailing edge. In this study, the transient nature of corrugated airfoils at low Reynolds number were assumed to be the flow is laminar, incompressible and two dimensional. The newly corrugated geometry which is parameterized from the camber line using a Radial basis function (RBF) based on interpolation method positioned at the lower surface of the airfoil i.e., NACA0015. Five morphed geometries are designed using ANSYS Space claimer. The computational domain is meshed using cartesian grid, the surface meshes with quadrilateral. Numerical simulations are performed with turbulent models i.e., k-omega, k-epsilon and Spalart allmaras. In the analysis, there is an increment of coefficient of lift and decrease in coefficient of drag by varying Reynolds number. Compared to NACA0015, corrugated NACA0015 shows good results.
Seasonal Analysis of Groundwater Samples from Borewells to Identify the Water Quality Index and its Comparative Statistical Analysis of Hunsur Taluk, Mysuru District, Karnataka, India.
Authors: Afshan Noushin , D Nagaraju , H.M Bhanuprakash , P Gagan Deep 
Published: November 2021

Abstract
Management and identification of groundwater quality are vital for the maintenance of freshwater sources in semi-arid and arid areas, which is important for sustainable development. Depending on the quality of the groundwater in various areas, the water quality control authorities can regulate the usage of water for either agriculture or drinking implementations since nearly 85% of India’s population is dependent on groundwater for their domestic and irrigation demand, particularly as a source of drinking in rural areas. This study is to explore and identify suitable areas for pumping groundwater for drinking and agricultural harvest from Hunsur taluk, Mysore district, Karnataka, India. A study of groundwater quality was conducted by analyzing the Water Quality Index (WQI) determined from 30 wells during two seasons of the year 2019 namely Pre-Monsoon and Post-Monsoon. The identification of the quality of water resources for irrigation and drinking purposes can be determined with the help of the Water Quality (WQI) index. The WQI index can be useful for the classification of the quality of drinking water as excellent, good, poor, very poor, or unsuitable for drinking. By using the Weighted Arithmetic Index methodwas calculated using the collected data, the analysis concludes that most of the groundwater samples harvested from the study area are ‘excellent water’, ‘good water’, and ‘poor water’. The IWQ index average for the study area is reported to be in the range of 17.35 to 65.64.
Delay-Induced Self-Organization Dynamics in a Prey-Predator Network with Diffusion
Authors: Hu Qing , Shen Jianwei 
Published: November 2021

Abstract
Time delays can induce the loss of stability and degradation of performance. In this paper, the pattern dynamics of a prey-predator network with diffusion and delay are investigated, where the inhomogeneous distribution of species in space can be viewed as a random network, and delay can affect the stability of the network system. Our results show that time delay can induce the emergence of Hopf and Turing bifurcations, which are independent of the network, and the conditions of bifurcation are derived by linear stability analysis. Moreover, we find that the Turing pattern can be related to the network connection probability. The Turing instability region involving delay and network connection probability is obtained. Finally, the numerical simulation verifies our results.
Mechanism Of Leptin On Impaired Ovarian Reserve Function After Cold Exposure In Female Rats
Authors: Wu Shuai , zhang li , Zhang Guanyu , Wei Wanting , Zhang Yongqiang , Li Xi , Yang Danfeng 
Published: November 2021

Abstract
Previous studies have shown that cold exposure can cause disturbance of estrus cycle in female rats. However, whether cold exposure can cause organic pathological damage to the reproductive system of female rats was undefined. Meanwhile there are few reports on the mechanism of decompensation in rat reproductive function after cold exposure. This study aims to further discuss how cold exposure impact female ovarian reserve function in rats. Female rats were randomly divided into control group and cold exposure group. Ovarian reserve function, differential genes in hypothalamus reproductive regulation center or peripheral were evaluated. After cold exposure, ovarian reserve function was impaired, follicle development was abnormal, the number of mature follicles decreased significantly, the key hypothalamic reproductive regulation molecule GnRH decreased significantly, the response of its regulatory receptor NPY-5R was down-regulated, and the peripheral hormone serum leptin, which is closely related to it, decreased significantly. Our results indicate that cold exposure can lead to impaired ovarian function in female rats, resulting from decrease in serum leptin cause by WAT leptin depletion, which can release the inhibitory of NPY in the hypothalamus, and further lead to the down-regulation of GnRH expression, resulting in the whole HPO axis.