bluuebunny/crossref_metadata_2025_split huggingface dataset:
Newly diagnosed cardiovascular disease in patients treated with immune checkpoint inhibitors: a retrospective analysis of patients at an academic tertiary care center
Authors: Waheed Nida , Fradley Michael G. , DeRemer David L. , Mahmoud Ahmad , Shah Chintan P. , Langaee Taimour Y. , Lipori Gloria P. , March Keith , Pepine Carl J. , Cooper-DeHoff Rhonda M. , Wu Yonghui , Gong Yan 
Published: March 2021

Abstract
Background
Immune checkpoint inhibitors (ICIs) are a novel class of anticancer agents that have demonstrated clinical response for both solid and hematological malignancies. ICIs are associated with development of immune-related adverse events including cardiotoxicity. We estimated the incidence of newly diagnosed cardiovascular disease in patients treated with ICIs at a large, tertiary care center.

Methods
All patients with a cancer diagnosis who received any ICI treatment in the University of Florida’s Integrated Data Repository from 2011 to 2017 were included. Cardiovascular disease was defined as a new ICD diagnosis code for cardiomyopathy, heart failure, arrhythmia, heart block, pericardial disease, or myocarditis after initiation of ICI treatment.

Results
Of 102,701 patients with a diagnosis of malignancy, 424 patients received at least one ICI. Sixty-two (14.6%) patients were diagnosed with at least one new cardiovascular disease after initiation of ICI therapy. Of the 374 patients receiving one ICI, 21 (5.6%) developed heart failure. Of the 49 patients who received two ICIs sequentially, three (6.1%) developed heart failure and/or cardiomyopathy. Incident cardiovascular disease was diagnosed at a median of 63 days after initial ICI exposure. One patient developed myocarditis 28 days after receiving nivolumab. Mortality in ICI treated patients with a concomitant diagnosis of incident cardiovascular disease was higher compared to those who did not (66.1% vs. 41.4%, odds ratio = 2.77, 1.55–4.95, p = 0.0006).

Conclusions
This study suggests a high incidence of newly diagnosed cardiovascular disease after the initiation of ICI therapy in a real-world clinical setting.
Role of some inflammatory biomarkers in prediction of short-term outcome in acute ischemic stroke
Authors: AlTaweel Yosria Abd Al Hameed , Nageeb Rania Sanad , Metwally Pakinam Mahmoud , Badawy Ahmed Elsayed 
Published: March 2021

Abstract
Background
Several factors affect acute ischemic stroke (AIS) outcomes.

Objective
This study aimed to assess the role of the leukocyte count, neutrophil/lymphocyte ratio (NLR), and c reactive protein (CRP) as early predictors of outcome in AIS patients.

Methods
This study was conducted on 60 AIS patients. They were subjected to detailed history taking, clinical examination, brain imaging, and laboratory assessment including the CRP, white blood cell (WBC) count, absolute neutrophil count (ANC), absolute lymphocyte count (ALC), and NLR which is calculated by dividing ANC by ALC. Neurological scales were used to assess the level of consciousness by the Glasgow Coma Scale (GCS) and stroke severity by the National Institute of Health Stroke Scale (NIHSS) at the first 48 h of stroke onset as well as 1 week and 2 weeks later for the assessment of short-term functional neurological outcome.

Results
Sixty percent of the patients had unfavorable outcomes assessed by the Modified Rankin Scale (mRS). Patients with unfavorable outcomes had higher NIHSS scores. NLR was positively correlated with WBC count, ANC, and CRP. The higher WBC, NLR, and NIHSS, the unfavorable the outcome was.

Conclusion
The higher WBC, the NLR, and the level of CRP at the onset of AIS, the more severe stroke and the poorer the short-term outcome are expected.
Physiological pacing to improve cardiac resynchronization therapy non-responder and a tryst with calcified septum—a case report
Authors: Arora Vanita , Zanon Francesco , Kumar Viveka , Kumar Vivek , Suri Pawan 
Published: March 2021

Abstract
Background
As per the literature, patients with intraventricular conduction delay (IVCD) do not respond well to cardiac resynchronization therapy (CRT) alone. They need advanced technological approach and out of the box thinking for a good response.

Case
Ours is a case of ischemic cardiomyopathy with wide QRS-IVCD, a non-responder to CRT. While planning for replacement of the device for early replacement indicator (ERI), we decided to do His-optimized CRT/left bundle optimized CRT (HOT-CRT/LOT-CRT) for the patient.

Conclusion
The challenges we faced with the present available hardware paved a way for insisting on the limitation of the available lumenless lead to penetrate calcified the septum and importance of the pre-procedure evaluation of intraventricular septum (IVS) for calcification by more than just echocardiography.
Imaging modalities in differential diagnosis of Parkinson’s disease: opportunities and challenges
Authors: Mortezazadeh Tohid , Seyedarabi Hadi , Mahmoudian Babak , Islamian Jalil Pirayesh 
Published: March 2021

Abstract
Background
Parkinson’s disease (PD) diagnosis is yet largely based on the related clinical aspects. However, genetics, biomarkers, and neuroimaging studies have demonstrated a confirming role in the diagnosis, and future developments might be used in a pre-symptomatic phase of the disease.

Main text
This review provides an update on the current applications of neuroimaging modalities for PD diagnosis. A literature search was performed to find published studies that were involved on the application of different imaging modalities for PD diagnosis. An organized search of PubMed/MEDLINE, Embase, ProQuest, Scopus, Cochrane, and Google Scholar was performed based on MeSH keywords and suitable synonyms. Two researchers (TM and JPI) independently and separately performed the literature search. Our search strategy in each database was done by the following terms: ((Parkinson [Title/Abstract]) AND ((“Parkinsonian syndromes ”[Mesh]) OR Parkinsonism [Title/Abstract])) AND ((PET [Title/Abstract]) OR “SPECT”[Mesh]) OR ((Functional imaging, Transcranial sonography [Title/Abstract]) OR “Magnetic resonance spectroscopy ”[Mesh]). Database search had no limitation in time, and our last update of search was in February 2021. To have a comprehensive search and to find possible relevant articles, a manual search was conducted on the reference list of the articles and limited to those published in English.

Conclusion
Early diagnosis of PD could be vital for early management and adequate neuroprotection. Recent neuroimaging modalities such as SPECT and PET imaging using radiolabeled tracers, MRI, and CT are used to discover the disease. By the modalities, it is possible to early diagnose dopaminergic degeneration and also to differentiate PD from others parkinsonian syndromes, to monitor the natural progression of the disease and the effect of neuroprotective treatments on the progression. In this regard, functional imaging techniques have provided critical insights and roles on PD.
Zinc and ascorbic acid treatment alleviates systemic inflammation and gastrointestinal and renal oxidative stress induced by sodium azide in rats
Authors: Akinrinde Akinleye Stephen , Fapuro Joseph , Soetan Kehinde Olugboyega 
Published: March 2021

Abstract
Background
Sodium azide (NaN3) is a chemical of rapidly increasing economic importance but with high toxic attributes. In this study, the effects of zinc (Zn) and ascorbic acid (AsA) supplementation on sodium azide (NaN3)-induced toxicity in the stomach, colon and kidneys were evaluated in Wistar rats. Twenty-eight rats were randomly allocated to four experimental groups as follows: group A (control) given distilled water only; group B (NaN3 only, 20 mg/kg); group C (NaN3 + zinc sulphate, ZnSO4 80 mg/kg); and group D (NaN3 + AsA 200 mg/kg).

Results
NaN3 was found to significantly (p < 0.05) induce increases in serum nitric oxide (NO), advanced oxidation protein products (AOPP), myeloperoxidase (MPO) and total protein levels, along with significant (p < 0.05) increase in gastric, colonic and renal malondialdehyde (MDA) and protein carbonyl (PCO) levels. In addition, NaN3 induced significant (p < 0.05) reduction in superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione S-transferase (GST) activities in the colon and kidneys. Treatment with Zn or AsA caused significant (p < 0.05) reduction in serum levels of oxidative and inflammatory markers, as well as tissue PCO and MDA levels. Moreover, co-treatment with Zn or AsA significantly (p < 0.05) restored colonic and renal levels of antioxidant enzymes, reduced glutathione and protein thiols.

Conclusions
This study shows that Zn or AsA supplementation alleviated NaN3 toxicity by suppressing systemic inflammation and preventing oxidative damage in the stomach, colon and kidneys of rats.
Phytochemical investigation and potential pharmacologically active compounds of Rumex nepalensis: an appraisal
Authors: Gonfa Yilma Hunde , Beshah Fekade , Tadesse Mesfin Getachew , Bachheti Archana , Bachheti Rakesh Kumar 
Published: March 2021

AbstractBackgroundRumex nepalensis, a widely known traditional medicinal plant and is used as the source of medicines and human diet in various communities. Currently, the phytochemical investigation and pharmacological studies ofR. nepalensisare of significant research interest. Therefore, the current review is mainly focused on the phytochemical investigation and pharmacological applications ofR. nepalensisMain bodyVarious secondary metabolites like emodin, endocrocin, chrysophanol, neopodin, physcion, torachrysone, aloesin, catechin, quercetin, resveratrol, and their derivatives were isolated from root and aerial parts of the plant. Both isolated compounds and extracts fromR. nepalensisare reported to have pharmacological activities such as anti-inflammatory, antioxidant, antimicrobial, wound healing, and anti-plasmodial activitiesConclusionsDifferent parts ofR. nepalensishave ethnomedicinal importance.R. nepalensisis one of the potential sources of pharmacologically active extracts and isolated compounds. In futureR. nepalensiscan play a vital role for the preparation of modern drugs.Graphical abstract
Leveraging Antiprogestins in the Treatment of Metastatic Breast Cancer
Authors: Kamaraju Sailaja , Fowler Amy M , Weil Elizabeth , Wisinski Kari B , Truong Thu H , Lehr Martin , Chaudhary Lubna N , Cheng Yee Chung , Chitambar Christopher R , Rui Hallgeir , Yee Douglas , Lange Carol 
Published: March 2021

Abstract
Although incurable, the prognosis for patients with metastatic breast cancer (MBC) has considerably improved with the approvals of multiple targeted and cytotoxic therapies. For hormone receptor-positive (HR+), ie, estrogen receptor and progesterone receptor positive (ER+/PgR+) and human epidermal growth factor receptor-2 negative (ie, ERBB2 gene nonamplified or HER2-) MBC, current approved treatment options include palliative endocrine therapy (ET), cyclin-dependent kinase (CDK 4/6) inhibitors, mTOR inhibitors, and PI3 kinase inhibitors. Most treatments target ER+ disease regardless of PgR status. Although the presence of PgR is crucial for ER+ cell proliferation in both normal and malignant mammary tissue, currently, there are no approved treatments that specifically target PgR. Recent literature has demonstrated the potential of antiprogestins in the treatment of MBC both in preclinical and clinical studies. Antiprogestins, including selective PgR modulators (SPRMs) that act as PgR antagonists, are a promising class of therapeutics for overcoming endocrine resistance in patients who develop activating estrogen receptor 1 (ESR1) and phosphatidylinositol 3-kinase (PI3K) gene mutations after prior endocrine therapy. Herein, we summarize the role of PgR and antiprogestins in the treatment of MBC. Other aspects on the use of functional imaging, clinical trials incorporating novel antiprogestins, and potential treatment combinations to overcome endocrine resistance will be briefly discussed.
Oviductal fluid counterbalances the negative effect of high temperature on sperm in an ectotherm model
Authors: Rossi N. , Lopez Juri G. , Chiaraviglio M. , Cardozo G. 
Published: March 2021

ABSTRACTGlobal warming is affecting biodiversity; however, the extent to which animal reproductive processes respond to predicted temperature increments remains largely unexplored. The thermal environment has a pronounced impact on metabolic rates of ectotherms; therefore, an interesting question to assess is whether temperature increase might affect specific reproductive mechanisms like sperm performance in ectotherms. Moreover, in many species, oviductal fluid (OF) is known to regulate and maintain sperm quality; however, the role of OF in relation to the effects of high temperature on sperm remains unclear. Our aim was to experimentally test the effect of increased temperature on sperm velocity, swimming path and percentage of motility in neutral conditions at ejaculation (without OF) and in female's reproductive tract fluid (with OF), in a social ectotherm lizard model, Tropidurus spinulosus, which has specific thermal requirements for reproduction. Our results suggest that a rising temperature associated with global warming (+4°C) affects negatively sperm dynamics and survival. However, OF ameliorated the harmful effects of high temperature. This is an important point, as this study is the first to have tested the role of OF in preserving sperm from a warmer pre-fertilization environment. These results contribute to our understanding of how thermal environment changes might affect post-copulatory reproductive mechanisms.This article has an associated First Person interview with the first author of the paper.
Genome size influences adaptive plasticity of water loss, but not metabolic rates, in lungless salamanders
Authors: Johnson Benjamin B. , Searle Jeremy B. , Sparks Jed P. 
Published: March 2021

ABSTRACT
Many expressions of phenotype, such as physiological performance, integrate multiple underlying traits to function. Linking component traits to adaptive physiology thus gives insight into mechanisms of selection acting on performance. Genome size (C-value) is a trait that influences physiology in multiple taxa by exerting a nucleotypic effect, constraining cell size and cellular physiology such that whole-organism mass-specific metabolism is reduced with increasing C-value. We tested for this mechanism of C-value function acting in lungless salamanders, plus an unexplored potential mechanism of C-value effects constraining water transport across the body surface to influence cutaneous water loss rates. We found no evidence for a nucleotypic effect on metabolic rates, but we demonstrate a relationship between C-value and water loss physiology. Under warmer experimental conditions, C-value was inversely correlated with water loss and positively correlated with resistance to water loss, which demonstrated adaptive plasticity at higher temperatures. We hypothesize that this pattern results from differences in cell size constraining diffusion and evaporation of water from the skin under warm conditions when cutaneous perfusion is reduced. Testing this hypothesis may confirm a previously unappreciated adaptive role for C-value variation in this group, and reveals the possibility that genome size influences physiological exchange across transport barriers more broadly.
High resolution ultrasonography of peripheral nerves in diabetic patients to evaluate nerve cross sectional area with clinical profile
Authors: Narayan Shamrendra , Goel Amit , Singh Ajai Kumar , Thacker Anup Kumar , Singh Neha , Gutch Manish 
Published: March 2021

Objectives:
The aim of this observational study was ultrasound evaluation of peripheral nerves cross-sectional area (CSA) in subjects with probable diabetic peripheral sensorimotor neuropathy (DPN). CSA was analyzed with reference to clinical and nerve conduction study’s (NCS) parameters for early diagnosis and pattern of involvement.

Methods:
A total of 50 patients with probable DPN due to Type 2 diabetes and 50 age-matched healthy controls underwent sonographic examinations of ulnar nerve at the lower arm, median nerve proximal to carpal tunnel, the common peroneal nerve proximal to fibular head, tibial nerve proximal to the tarsal tunnel, and sural nerve at lower third leg.

Results:
CSA was increased in cases of DPN as compared to healthy controls. Area changes were more marked with demyelinating pattern. Probable DPN cases with normal NCS had significantly higher number of peripheral nerves showing increased CSA as compared to healthy control. A cut-off of &gt;4 nerve thickening showed a sensitivity of 86 %, and specificity of 56%. The neuropathy pattern in the lower limb was axonal, whereas in the upper limb, it was demyelinating with the majority showing sonographic feature of associated compressive neuropathy.

Conclusion:
There is an increase in CSA of peripheral nerve in diabetic patients. It can be used as a morphological marker for classifying DPN with changes being picked up earlier to NCS abnormality. Clinical neurological presentation in probable DPN can also be due to compressive neuropathy in early phases, and ultrasound can be a useful tool.

Advances in knowledge:
Early pick up of DPN cases shall be useful for early therapy and motivating the patients to actively participate in the treatment. Morphological changes on ultrasonography precedes the electrodiagnostic change in DPN. Symptoms of DPN is not only due to metabolic changes but also compressive neuropathy.
right under our noses: the postponement of children's political equality and the NOW
Authors: Haynes Joanna , Murris Karin 
Published: March 2021

Responding to the invitation of this special issue of Childhood and Philosophy this paper considers the ethos of facilitation in philosophical enquiry with children, and the spatial-temporal order of the community of enquiry. Within the Philosophy with Children movement, there are differences of thinking and practice on ‘facilitation’ in communities of philosophical enquiry, and we suggest that these have profound implications for the political agency of children. Facilitation can be enacted as a chronological practice of progress and development that works against child, in terms of political agency. This paper theorises practices of facilitation grounded in philosophies of childhood that assume listening to child/ren as equals, as already able to philosophise, and against sameness. We explore the political and ethical implications of the radical posthumanist reconfiguration of the ‘zipped’ body in the light of including the disciplinary, imaginative and enabling energies of chronological time through the concept now/ness. We shift from ethics to ethos, and from ‘zipped’ to ‘unzipped’ bodies, through the notion of affect to explore the temporal and spatial dimensions of facilitation in Philosophy with Children and children’s political agency. We re-turn to David McKee’s Not Now Bernard (1980), getting ‘inside the text’, and attending to the postponement of equality in Philosophy with Children.
Zoom lens with high zoom ratio design based on Gaussian bracket and particle swarm optimization
Authors: Fan Chengxiang , Yang Bo , Liu Yunpeng , Gu Pengxiang , Wang Xingqi , Zong Hui 
Published: March 2021

In this paper, we use Gaussian brackets and a particle swarm optimization (PSO) algorithm to design a

20
×

four-group zoom lens with a focus tunable lens and two moving groups. This method uses Gaussian brackets to derive the paraxial design equations of the zoom lens and determine the lens parameters. In the optimization stage, we define an objective function as a performance indicator to optimize its first-order design and implement the PSO algorithm in MATLAB to find its global optimal first-order design. The optimized

20
×

zoom lens has a focal length of 4.5–90 mm and a total length of 145 mm. This method solves the difficulty of solving the initial structure of the zoom. Compared with traditional trial and error, the calculation speed is faster, the accuracy is higher, and it does not rely on the initial value. The results show that this method is suitable for the first-order design of complex optical systems.
Photo-assisted self-interference cancellation for in-band full-duplex radio-over-fiber system
Authors: Wang Jiaojiao , Yu Haiyang , Zhao Zeping , Zhang Zhike , Liu Jianguo 
Published: March 2021

An optical approach to cancel the radio frequency self-interference for an in-band full-duplex radio-over-fiber system is proposed and experimentally demonstrated based on two Mach–Zehnder modulators and a balanced photodetector (BPD). The cancellation depth is larger than 50 dB and 24 dB for the single frequency and for a wideband signal, respectively. The application of the BPD eliminates the common mode noise and reduces no system flexibility because signal transmission is in one optical fiber by polarization multiplexing technology, instead of two fibers in the traditional self-interference cancellation system with a BPD. In addition, with no electrical delay and attenuation applied, the operational frequency band and cancellation depth are not confined by electronic devices.
Chirality parameter sensing based on surface plasmon resonance D-type photonic crystal fiber sensors
Authors: Fan Bo , Zhang Tongmengxue , He Simin , Wang Maoyan , Li Hailong , Yu Mengxia , Li Guiping , Xu Jun 
Published: March 2021

We report a method to sense a surrounding chiral drug based on D-type single-mode photonic crystal fiber (PCF) sensors in this paper. The electromagnetic theory of surface plasmon resonance on metal-chiral drug structure is derived. The wave equation containing constitutive relations of a chiral drug is given and integrated into the finite element method to compute the effective refractive index, confinement loss, and plasmon resonance wavelength for a D-type PCF sensor immersed in the chiral drug. The effects of the chirality parameter on resonance behaviors are displayed. The wavelength sensitivities of the chirality parameter for the sensor changing with different kinds of metal film layers, side-polished depth, and thickness of metal film layer are calculated. The wavelength sensitivity can reach a maximum of 17,580 nm/chirality as the refractive index and chirality parameter of the drug are 1.36 and 0.08, respectively. Furthermore, simultaneous dual-parameter detection of the chirality parameter and refractive index is realized by using two different D-type PCF sensors with gold and silver metal film layers, respectively. This study may provide sufficient guidelines to the field of biochemical sensing.
Characterization of a chromatic confocal displacement sensor integrated with an optical laser head
Authors: Zakrzewski A. , Jurewicz P. , Koruba P. , Ćwikła M. , Reiner J. 
Published: March 2021

In this paper, the results of experimental characterization of an optical system consisting of a chromatic confocal displacement sensor integrated with an optical laser head are presented. As a result of integration, the part of the optical path of the displacement sensor was combined with the optical path of the laser beam. Consequently, a working distance of 250 mm for the optical system was achieved. The main aim of the characterization was to determine the calibration curve, as well as the application parameters of the system. The methodology for spectral data processing with particular emphasis on the effectiveness of various extraction algorithms is presented. The Lorentzian fitting was considered as the optimal algorithm for the optical system. Consequently, a large measuring range of 10 mm was obtained with perfect linear tendency of the calibration curve. The optical system was characterized by high accuracy equal to

±

0.11

%

of the measuring range, as well as 1 µm resolution. Moreover, the functionality of the system was verified on materials commonly used in laser processing and additive manufacturing. Finally, the system was validated through a comparative measurement with a laser profiler.