bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential biomarkers of major depression diagnosis and chronicity
Authors: Galvão Ana Cecília de Menezes , Almeida Raíssa Nobrega , de Sousa Júnior Geovan Menezes , Leocadio-Miguel Mário André , Palhano-Fontes Fernanda , de Araujo Dráulio Barros , Lobão-Soares Bruno , Maia-de-Oliveira João Paulo , Nunes Emerson Arcoverde , Hallak Jaime Eduardo Cecilio , Sarris Jerome , Galvão-Coelho Nicole Leite 
Published: September 2021

Background
Molecular biomarkers are promising tools to be routinely used in clinical psychiatry. Among psychiatric diseases, major depression disorder (MDD) has gotten attention due to its growing prevalence and morbidity.

Methods
We tested some peripheral molecular parameters such as serum mature Brain-Derived Neurotrophic Factor (mBDNF), plasma C-Reactive Protein (CRP), serum cortisol (SC), and the salivary Cortisol Awakening Response (CAR), as well as the Pittsburgh sleep quality inventory (PSQI), as part of a multibiomarker panel for potential use in MDD diagnosis and evaluation of disease’s chronicity using regression models, and ROC curve.

Results
For diagnosis model, two groups were analyzed: patients in the first episode of major depression (MD: n = 30) and a healthy control (CG: n = 32). None of those diagnosis models tested had greater power than Hamilton Depression Rating Scale-6. For MDD chronicity, a group of patients with treatment-resistant major depression (TRD: n = 28) was tested across the MD group. The best chronicity model (p < 0.05) that discriminated between MD and TRD included four parameters, namely PSQI, CAR, SC, and mBDNF (AUC ROC = 0.99), with 96% of sensitivity and 93% of specificity.

Conclusion
These results indicate that changes in specific biomarkers (CAR, SC, mBDNF and PSQI) have potential on the evaluation of MDD chronicity, but not for its diagnosis. Therefore, these findings can contribute for further studies aiming the development of a stronger model to be commercially available and used in psychiatry clinical practice.
Trends in urinary tract infection hospitalization in older adults in Spain from 2000-2015
Authors: Redondo-Sánchez Jesús , del Cura-González Isabel , Díez-Izquierdo Laura , Rodríguez-Barrientos Ricardo , Rodríguez-Cabrera Francisco , Polentinos-Castro Elena , López-Miguel Miguel , Marina-Ono Lucas , Llamosas-Falcón Laura , Gil-de Miguel Ángel 
Published: September 2021

Objective
To analyze trends in urinary tract infection hospitalization (cystitis, pyelonephritis, prostatitis and non-specified UTI) among patients over 65 years in Spain from 2000–2015.

Methods
We conducted a retrospective observational study using the Spanish Hospitalization Minimum Data Set (CMBD), with codifications by the International Classification of Diseases (ICD-9). We collected data on sex, age, type of discharge, main diagnosis, comorbid diagnosis, length of stay, and global cost. All the hospitalizations were grouped by age into three categories: 65–74 years old, 75–84 years old, and 85 years old and above. In the descriptive statistical analysis, crude rates were defined as hospitalizations per 1,000 inhabitants aged ≥65. To identify trends over time, we performed a Joinpoint regression.

Results
From 2000–2015, we found 387,010 hospitalizations coded as UTIs (54,427 pyelonephritis, 15,869 prostatitis, 2643 cystitis and 314,071 non-specified UTI). The crude rate of hospitalization for UTIs between 2000 and 2015 ranged from 2.09 in 2000 to 4.33 in 2015 Rates of hospitalization were higher in men than in women, except with pyelonephritis. By age group, higher rates were observed in patients aged 85 years or older, barring prostatitis-related hospitalizations. Joinpoint analyses showed an average annual percentage increase (AAPC) in incidence rates of 4.9% (95% CI 3.2;6.1) in UTI hospitalizations. We observed two joinpoints, in 2010 and 2013, that found trends of 5.5% between 2000 and 2010 (95% CI 4.7;6.4), 1.5% between 2010 and 2013 (95% CI -6.0;9.6) and 6.8% between 2013 and 2015 (95% CI -0.3;14.4).

Conclusions
The urinary infection-related hospitalization rate in Spain doubled during the period 2000–2015. The highest hospitalization rates occurred in men, in the ≥85 years old age group, and in non-specified UTIs. There were increases in all types of urinary tract infection, with non-specified UTIs having the greatest growth. Understanding these changing trends can be useful for health planning.
Barriers and facilitators for optimizing oral anticoagulant management: Perspectives of patients, caregivers, and providers
Authors: Holbrook Anne , Wang Mei , Swinton Marilyn , Troyan Sue , Ho Joanne M. W. , Siegal Deborah M. 
Published: September 2021

Background
Oral anticoagulants (OACs) are very commonly prescribed for prevention of serious vascular events, but are also associated with serious medication-related bleeding. Mitigation of harm is believed to require high-quality OAC management. This study aimed to identify barriers and facilitators for optimal OAC management from the perspective of patients, caregivers and healthcare providers.

Methods
Using a qualitative descriptive study design, we conducted five focus groups, three with patients and caregivers and two with health care providers, in two health regions in Southwestern Ontario. An expert facilitator led the discussions using a semi-structured interview guide. Each session was digitally recorded, transcribed verbatim and anonymized. Transcripts were analyzed in duplicate using conventional content analysis.

Results
Forty-two (19 patients, 7 caregivers, and 16 providers including physicians, nurses and pharmacists) participated. More than half of the patients received OAC for the treatment of venous thromboembolism (57.9%) and the majority (94.7%) were on chronic therapy (defined as >3 years). Data analysis organized codes describing barriers and facilitators into 4 main themes—medication-related, patient-related, provider-related, and system-related. Barriers highlighted were problems with medication access due to cost, patient difficulties with adherence, knowledge and adjusting their lifestyles to OAC therapy, provider expertise, time for adequate communication amongst providers and their patients, and health care system inadequacies in supporting communications and monitoring. Facilitators identified generally addressed these barriers.

Conclusions
Many barriers to optimal OAC management exist even in the era of DOACs, many of which are amenable to facilitators of improved care coordination, patient education, and adherence monitoring.
Immunological investigations of the cerebrospinal fluid in patients with recent onset psychotic disorders: A study protocol
Authors: Jeppesen Rose , Orlovska-Waast Sonja , Vindegaard Sørensen Nina , Christensen Rune Haubo Bojesen , Benros Michael Eriksen 
Published: September 2021

BackgroundThough many previous studies have indicated immunological alterations in psychotic disorders, the role and prevalence of neuroinflammation is still unknown. Studies previously investigating immune related biomarkers in the cerebrospinal fluid (CSF) of these patients are mainly small studies on few markers, and many have not compared patients to healthy controls.MethodsWe will conduct a large case-control study including at least 100 patients with recent onset psychotic disorders and 100 sex- and age matched healthy controls. The cases will include patients diagnosed with a psychotic disorder according to ICD-10 (F20/F22-29) within a year prior to inclusion. We will collect both CSF, blood and fecal samples, to gain insight into possible immunological alterations. The psychopathology of all participants will thoroughly be evaluated using the SCAN interview, and multiple rating scales covering different symptom groups. All participants will partake in a detailed neurological examination, including the Neurological Evaluation Scale assessing neurological soft signs. Additionally, we will assess cognitive functioning, evaluate quality of life and level of functioning, and collect data on a broad array of possible confounders. Our primary outcomes will include CSF leucocytes, CSF/serum albumin ratio, CSF total protein, IgG index, CSF levels of IL-6 and IL-8, and presence of antineuronal autoantibodies in CSF and blood. For our secondary outcomes, exploratory analyses will be performed on a broader panel of neuroimmunological markers. All participants will be invited for a follow-up visit to assess longitudinal changes. The current study is part of a larger CSF biobank build-up for severe mental disorders (PSYCH-FLAME).DiscussionThis study will represent the largest investigation of CSF in patients with psychotic disorders compared to healthy controls to date. We expect the study to contribute with new, important knowledge on pathophysiological mechanisms, and to help pave the way for future investigations of individualized treatment options.Trial registrationThe study is approved by The Regional Committee on Health Research Ethics (Capital Region, j.no: H-16030985) and The Danish Data Protection Agency (j.no: RHP-2016-020, I-Suite no.: 04945).
Telehealth at scale can improve chronic disease management in the community during a pandemic: An experience at the time of COVID-19
Authors: Omboni Stefano , Ballatore Tommaso , Rizzi Franco , Tomassini Fernanda , Panzeri Edoardo , Campolo Luca 
Published: September 2021

BackgroundDuring the COVID-19 pandemic, telehealth became a vital resource to contain the virus’s spread and ensure continuity of care of patients with a chronic condition, notably arterial hypertension and heart disease. This paper reports the experience based on a telehealth platform used at scale to manage chronic disease patients in the Italian community.Methods and findingsPatients’ health status was remotely monitored through ambulatory blood pressure monitoring (ABPM), resting or ambulatory electrocardiogram (ECG), spirometry, sleep oximetry, and cardiorespiratory polysomnography performed in community pharmacies or general practitioners’ offices. Patients also monitored their blood pressure (BP), heart rate (HR), blood oxygen saturation (SpO2), body temperature, body weight, waist circumference, blood glucose, and lipids at home through a dedicated smartphone app. All data conveyed to the web-based telehealth platform were used to manage critical patients by doctors promptly. Data were analyzed and compared across three consecutive periods of 2 months each: i) before the national lockdown, ii) during the lockdown (from March 9 to May 17, 2020), and iii) after the end of the containment measures. Overall, 13,613 patients visited community pharmacies or doctors’ offices. The number of overall tests dropped during and rose after the lockdown. The overall proportion of abnormal tests was larger during the outbreak. A significant increase in the prevalence of abnormal ECGs due to myocardial ischemia, contrasted by a significantly improved BP control, was observed. The number of home users and readings exchanged increased during the pandemic. In 226 patients, a significant increase in the proportion of SpO2readings and a significant reduction in the entries for all other parameters, except BP, was observed. The proportion of abnormal SpO2and BP values was significantly lower during the lockdown. Following the lockdown, the proportion of abnormal body weight or waist circumference values increased.ConclusionsOur study results support the usefulness of a telehealth solution to detect deterioration of the health status during the COVID-19 pandemic.Trial registrationThe study is registered with ClinicalTrials.gov at numberNCT03781401.
Surrogacy and the Reproduction of Normative Family on TV, Lulu La Vey (2019)
Authors: Fryett Sarah E. 
Published: September 2021

Review of: Surrogacy and the Reproduction of Normative Family on TV, Lulu La Vey (2019)
Cham: Palgrave Macmillan, 258 pp.,
ISBN 978-3-030-17569-6, eBook, £35.99
ISBN 978-3-030-17569-6, h/bk, £64.99
ISBN 978-3-030-17572-6, p/bk, £44.99
Detecting concealed language knowledge via response times
Authors: Lukács Gáspár , Kawai Claudia , Ansorge Ulrich , Fekete Anna 
Published: September 2021

AbstractIn the present study, we introduce a response-time-based test that can be used to detect concealed language knowledge, for various potential applications (e.g., espionage, border control, counter-terrorism). In this test, the examinees are asked to respond to repeatedly presented items, including a real word in the language tested (suspected to be known by the examinee) and several pseudowords. A person who understands the tested language recognizes the real word and tends to have slower responses to it as compared to the pseudowords, and, thereby, can be distinguished from those who do not understand the language. This was demonstrated in a series of experiments including diverse participants tested for their native language (German, Hungarian, Polish, Russian;n = 312), for second language (English, German;n = 66), and several control groups (n = 192).
Primed progressives? Predicting aspectual choice in World Englishes
Authors: Rautionaho Paula , Hundt Marianne 
Published: September 2021

AbstractThis corpus-based study focuses on the progressive:non-progressive alternation from a novel perspective, i.e. the effect of syntactic priming. We annotated a dataset of 5,000 progressive and non-progressive occurrences in ten different varieties of English from theInternational Corpus of Englishfor variables such as Aktionsart categories and elements related to priming and subjected the data to a generalized linear mixed methods tree analysis. The results indicate that the progressive is most likely to occur in situations that are durative in nature and when they are preceded by another progressive; overall, we find some evidence of probabilistic indigenization with regard to the use of progressives in different varieties. However, while syntactic priming seems to play a role overall in the choice of the progressive over the non-progressive, we do not find evidence supporting the idea that priming may explain the use of non-standard stative progressives.
Probabilistic and deterministic analysis of single diode model of a solar cell: a case study
Authors: Samadhiya Akshit , Namrata Kumari 
Published: September 2021

Abstract
The paper presents a probabilistic and deterministic analysis for parameterization of solar cells to study the electrical behavior based on single diode model. Estimation of electrical parameters is important in design, control, and delivery of solar power through a solar cell. Due to non-linearity and non-convexity of the parameterization problem, the single objective function is transformed into set of sub-problems through Pascoletti–Serafini Scalarization using ε -constraint method. Thus, each sub-problem is minimized to obtain a unique set of points on Pareto front. The results are compared with multi-variable Newton Raphson (NR), Particle Swarm Optimization (PSO), and Black Widow Optimization (BWO) based on convergence accuracy, precision and ability to trace non-convex region. Solarex MSX83 (36 cells) is considered as the test case for the validation of deterministic optimization models under Standard test Conditions (STCs). Electrical characteristics are plotted under STC (1000 W/m2, 1.5 A.M. spectrum, 25 °C) which shows fair agreement with the actual experimental curves present in the datasheet. The results obtained from the proposed bi-objective minimization algorithm shows a better convergence response with an additional benefit of tracing the convexity of the problem. Moreover, the proposed technique also ensures a good fit as suggested by the statistical means. Finally, a probabilistic model is proposed for single diode model of a solar cell in the presence of parametric uncertainty. Random samples of uncertain electrical parameters are obtained using Latin hypercube and Monte Carlo sampling methods to estimate the probability of the output response. It can be concluded that the objective function shows a bi-modal distribution under parametric variations which may arise due to measurement error, shading losses, surface defects, and manufacturing issues.
Experimental synthesis of partially coherent beam with controllable twist phase and measuring its orbital angular momentum
Authors: Wang Haiyun , Peng Xiaofeng , Zhang Hao , Liu Lin , Chen Yahong , Wang Fei , Cai Yangjian 
Published: September 2021

Abstract
Twist phase is a nontrivial second-order phase that only exists in a partially coherent beam. Such twist phase endows the partially coherent beam with orbital angular momentum (OAM) and has unique applications such as in super-resolution imaging. However, the manipulation and the detection of the twist phase are still far from easy tasks in experiment. In this work, we present a flexible approach to generate a famous class of twisted Gaussian Schell-model (TGSM) beam with controllable twist phase by the superposition of the complex field realizations using a single phase-only spatial light modulator. The precise control of the amplitude and phase of the field realizations allows one to manipulate the strength of the twist phase easily. In addition, we show that the twist factor, a key factor that determines the strength of twist phase and the amount of OAM, can be measured by extracting the real part of the complex degree of coherence of the TGSM beam. The experiment is carried out with the help of the generalized Hanbury Brown and Twiss experiment as the generated TGSM beam obeys Gaussian statistics. The flexible control and detection of the twist phase are expected to find applications in coherence and OAM-based ghost imaging.
Formability Characterization of Fiber Reinforced Polymer Composites Using a Novel Test Method
Authors: Janicki Joseph C. , Egloff Matthew C. , Amendola Roberta , Ryan Cecily A. , Bajwa Dilpreet S. , Dynkin Alexey , Cairns Douglas S. 
Published: September 2021

Abstract
Fiber reinforced polymer composites are often used as a replacement for metal alloys because of the superior strength to weight ratio. However, a major drawback of these materials is the lack of formability caused by the low strain to failure ratio that does not allow the material to follow tooling contours into deep drawn shapes or tight radii. Composite materials have a multiscale hierarchical structure where micro and meso scale effects (fiber and tow scales) contribute to the macro structural response (laminate scale). In particular, during forming, different deformation occurs simultaneously at every scale. Currently, the amount of quantifiable and comparable forming data for both continuous and discontinuous fiber reinforced polymer composites, including a multi-scale understanding of the deformation response, is limited because of the lack of a testing system. This article proposes a novel test method and an apparatus called “the forming fixture” for testing the tow formability of fiber reinforced polymer composites by determining the required load to form an uncured resin impregnated fiber tow sample into a stretch drawn profile. Test results from forming of Hexcel (Stamford, CT) IM7-G continuous carbon fiber impregnated with Huntsman (The Woodlands, TX) RDM 2019-053 resin system, in the temperature range of 21°C–121°C, are discussed to demonstrate the use of the proposed apparatus including representative data. Results showed consistency and repeatability, validating the reliability of the novel method. The test aided in defining the forming behavior of the material in real time both visually (e.g. sample failure location) and as forming load versus displacement curves. A novel forming metrics, relating the maximum drawing depth with no failure and the maximum forming load, is defined to compare and select different fiber and resin formulations. Widespread adoption of the forming fixture will reduce reliance on a “trial and error” approach during the the forming process.
Acromegaly in remission: a view from the partner
Authors: Fourneaux Rachel , Vermalle Marie , Albarel Frederique , Morange Isabelle , Graillon Thomas , Amodru Vincent , Cuny Thomas , Dufour Henry , Brue Thierry , Castinetti Frederic 
Published: September 2021

Objective
A relative can be an asset in dealing with chronic illnesses, such as acromegaly, where quality of life (QoL) is altered even after remission. However, it has been shown that quality of life of caregivers can also be impacted. Our main objective was to compare the perception of acromegaly in remission in the patient–relative dyad.

Methods
In this observational study, 27 patients in remission and relatives were first asked to complete QoL, anxiety/depression and coping strategy questionnaires. Then, the patient’s body image and self-esteem were evaluated from both the patient’s and the relative’s point of view using the same questionnaires with modified instructions.

Results
Relatives had overall an accurate estimation of patient body image using the Figure Rating Scale by Stunkard. However, there were wide variations between the patient’s and the relative’s responses regarding self-esteem and body perception. The QoL of relatives was not altered and was significantly higher in the social domain than for the patient.

Conclusions
Our results show that relatives require education concerning all the steps involved in the management of acromegaly, as they likely do not fully understand the sequelae of acromegaly.
Nature and Children’s Health: A Systematic Review
Authors: Fyfe-Johnson Amber L. , Hazlehurst Marnie F. , Perrins Sara P. , Bratman Gregory N. , Thomas Rick , Garrett Kimberly A. , Hafferty Kiana R. , Cullaz Tess M. , Marcuse Edgar K. , Tandon Pooja S. 
Published: September 2021

CONTEXTDaily outdoor play is encouraged by the American Academy of Pediatrics. Existing evidence is unclear on the independent effect of nature exposures on child health.OBJECTIVEWe systematically evaluated evidence regarding the relationship between nature contact and children’s health.DATA SOURCESThe database search was conducted by using PubMed, Cumulative Index to Nursing and Allied Health Literature, PsychInfo, ERIC, Scopus, and Web of Science in February 2021.STUDY SELECTIONWe followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. In all searches, the first element included nature terms; the second included child health outcome terms.DATA EXTRACTIONOf the 10 940 studies identified, 296 were included. Study quality and risk of bias were assessed.RESULTSThe strongest evidence for type of nature exposure was residential green space studies (n = 147, 50%). The strongest evidence for the beneficial health effects of nature was for physical activity (n = 108, 32%) and cognitive, behavioral, or mental health (n = 85, 25%). Physical activity was objectively measured in 55% of studies, and 41% of the cognitive, behavioral, or mental health studies were experimental in design.LIMITATIONSTypes of nature exposures and health outcomes and behaviors were heterogenous. Risk of selection bias was moderate to high for all studies. Most studies were cross-sectional (n = 204, 69%), limiting our ability to assess causality.CONCLUSIONSCurrent literature supports a positive relationship between nature contact and children’s health, especially for physical activity and mental health, both public health priorities. The evidence supports pediatricians in advocating for equitable nature contact for children in places where they live, play, and learn.