bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model Evaluasi CIPP dalam Mengevaluasi Program Tahfiz Selama Daring di SMP Islam Al-Ishlah Bukittinggi
Authors: Doyok Ris 
Published: August 2021

Program tahfihz di SMP Islam Al-Ishlah Bukittinggi selama daring (online) mengalami perubahan yang sangat signifikan, mulai dari kesiapan lembaga, guru, siswa, fasilitas, terutama pada saat pelaksanaan proses pembelajaran daring (online) berbagai kendala dihadapi. Tujuan penelitian ini untuk mengetahui implementasi program tahfiz selama proses pembelajaran daring (online). Metode penelitian menggunakan pendekatan kualitatif dengan model evaluasi CIPP (context, input, process, dan product). Hasil dari penelitian ini menunjukkan bahwa evaluasi konteks sudah baik, evaluasi masukan bisa dikatakan baik, evaluasi proses mengalami hambatan yang cukup mengkhawatirkan proses kelangsungan program tahfiz diakibatkan pandemi Covid-19 ini sehingga sangat berdampak pada proses pembelajaran tahfiz, dan evaluasi produk menunjukkan tingkat keberhasilan jauh dari apa yang telah direncanakan. Maka bisa dikatakan bahwa keberhasilan program tahfiz di masa pandemi Covid-19 mengalami kemunduran atau target yang diharapkan tidak tercapai.
The tahfihz program at Al-Ishlah Islamic Junior High School Bukittinggi while online underwent very significant changes starting from the readiness of institutions, teachers, students, facilities, especially during the implementation of the online learning process, various obstacles were encountered. The aim is to find out how the tahfiz program is implemented during the online learning process. This research method uses a qualitative approach with the CIPP evaluation model (context, input, process, and product). The results of this study indicate that the context evaluation is good, the evaluation of the input can be said to be good, the evaluation of the process experienced obstacles that were quite worrying for the continuity of the tahfiz program due to the Covid-19 pandemic so that it greatly affected the tahfiz learning process, and the product evaluation showed a success rate far from what had been planned. So, it can be said that the success of the tahfiz program during the Covid-19 pandemic experienced a setback or the expected target was not achieved.
PENDAMPINGAN PROSES PRODUKSI MAKANAN RINGAN DI PD. NESIF DESA DAYEUH MANGGUNG KABUPATEN GARUT
Authors: Nurwathi Nurwathi , Azwar Ade Geovania , Mardiana Novi , Munandar Ahmad , Pitoyo Djoko , Nasrudin Inayati , Nurbani Sofiani Nalwin , Nurhayati Lina 
Published: August 2021

Kebijakan pemerintah dalam integrase dan menaikkan kelas UMKM harus didukung oleh masyarakat. Prodi Teknik Industri mendukung kebijkan tersebut dengan melakukan pendampingan proses produksi pada PD NESIF. Proses Produksi PD NESIF masih sangat tradisional. Hal ini ditandai dengan belum adanya standar proses produksi yang dimiliki oleh PD NESIF. Semua proses produksi dilakukan dengan Estimasi Analogous yang berdasarkan data proses produksi yang pernah dilakukan. Proses produksi yang baik tentu diharapkan dapat meningkatkan kualitas produk. Tujuan pengabdian pada masyarakat ini adalah melakukkan pendampingan UMKM PD NESIF sebagai bidang Teknik Industri. Tahap awal pendampingan merupakan proses survey dan observasi permasalahan yang kemudian didiskusikan dalam implementasinya. . Hasil Pendampingan didapatkan bahwa PD NESIF memiliki keinginan untuk memperbaiki proses produksi namun masih terkendala Motivasi dan komitmen jangka panjang.
Dubens dugno raumenų stiprinimo pratimų poveikis šlapimo nelaikymo sutrikimui moterims po gimdos pašalinimo operacijos
Authors: Jankūnas Deividas , Sipavičienė Saulė , Stakauskienė Simona , Milinavičienė Eglė 
Published: August 2021

Tyrimo pagrindimas. Histerektomija – tai procedūra, kurios metu chirurginiu būdu pašalinama gimda. Histerektomijos apimtis ir būdas gali skirtis, tačiau pati chirurginė intervencija yra pooperacinio šlapimo nelaikymo rizikos veiksnys nepriklausomai nuo operacijos apimties ir būdo (Skorupska, Miotla, Kubik–Komar, Rechberger, Adamiak–Godlewska, Rechberger, 2016). Šlapimo nelaikymo prevencijos metodai: tinkamo kūno svorio palaikymas, gimdymų ribojimas, gyvenimo būdo korekcija, mokymas taisyklingai atlikti dubens dugno raumenų (DDR) treniravimo pratimus (Habib, Chaudhary, 2016). Tačiau vis dar stinga tyrimų duomenų, kaip DDR treniravimą būtų galima derinti su kitomis intervencijomis (Silantyeva, ir kt., 2019), skirtingi autoriai pateikia prieštaringus rezultatus.
Tikslas – įvertinti DDR stiprinimo pratimų programų poveikį šlapimo nelaikymo sutrikimui moterims po gimdos pašalinimo operacijos.
Metodai. Pirmai tiriamųjų grupei taikytas grįžtamasis ryšys ir įprasta kineziterapija (GR + IK), antrai – tik įprasta kineziterapija (IK). Visoms tiriamosioms įvertintas jaučiamas skausmas, DDR jėga, gyvenimo kokybė, susijusi su šlapimo nelaikymo problema, bendroji gyvenimo kokybė prieš poveikio taikymą ir po jo. Skausmo intensyvumas ir DDR jėga papildomai įvertinti po 5 ir 10 dienų.
Rezultatai. Po poveikio taikymo pastebėtas reikšmingas rezultatų pagerėjimas GR + IK grupėje: padidėjo DDR jėga, pagerėjo gyvenimo kokybė, susijusi su šlapimo nelaikymo problema, palyginus su IK grupe (p < 0,05). Jaučiamas skausmas ir bendrosios gyvenimo kokybės rezultatai tarp grupių reikšmingai nesiskyrė (p > 0,05).
Išvados. Įprasta kineziterapija, derinama su grįžtamuoju ryšiu, elgsenos požiūriu yra veiksmingesnė dubens dugno raumenų jėgai didinti, gyvenimo kokybei, susijusiai su šlapimo nelaikymu, gerinti nei vien tik įprasta kineziterapija.
Raktažodžiai: histerektomija, dubens dugno raumenys, dubens dugno raumenų treniravimas, šlapimo nelaikymas, kineziterapija.
β-Hydroxybutyric Inhibits Vascular Calcification via Autophagy Enhancement in Models Induced by High Phosphate
Authors: Liang Jianwen , Huang Jieping , He Wanbing , Shi Guangzi , Chen Jie , Huang Hui 
Published: August 2021

Background: Vascular calcification (VC) is a landmark of aging, while β-hydroxybutyric acid (BHB) induced by calorie restriction has been identified as a promising factor to extend the lifespan. However, the effect of BHB on VC and the potential mechanism remain unknown.Methods: A total of 160 subjects with or without metabolic abnormalities (MAs) were assigned to four groups according to different calcification severities. The association between BHB, MAs, and VC was investigated via mediation analysis. Then, with high phosphate-induced calcification models, the effect of BHB on arterial ring calcification and osteogenic phenotypic differentiation of vascular smooth muscle cells (VSMCs) was investigated. Hereafter the expressions of autophagy biomarkers, autophagy flux, and effects of autophagy inhibitors on VC were detected.Results: Severe VC was observed in the elderly, accompanied with a higher proportion of hypertension, chronic kidney disease, and lower estimated glomerular filtration rate. The serum BHB level was an independent influencing factor of VC severities. With mediation analysis, BHB was determined as a significant mediator in the effects of MAs on VC, and the indirect effect of BHB accounted for 23% of the total effect. Furthermore, BHB directly inhibited arterial ring calcification and osteogenic phenotypic differentiation in VSMCs, accompanied with autophagy enhancement in VSMCs. In accordance, the inhibition of autophagy counteracted the protective effect of BHB on VC.Conclusion: The present study demonstrated that BHB mediated the effects of MAs on VC; then, it further elucidated that BHB could inhibit arterial and VSMC calcification via autophagy enhancement.
Improvement of LV Reverse Remodeling Using Dynamic Programming of Fusion-Optimized Atrioventricular Intervals in Cardiac Resynchronization Therapy
Authors: Wang Zhongkai , Li Pan , Zhang Bili , Huang Jingjuan , Chen Shaoping , Cai Zhuhong , Qin Yingyi , Fan Jihai , Tang Wendong , Qin Yongwen , Li Ruogu , Zhao Xianxian 
Published: August 2021

Background: The patient-tailored SyncAV algorithm shortens the QRS duration (QRSd) beyond what conventional biventricular (BiV) pacing can. However, evidence of the ability of SyncAV to improve the cardiac resynchronization therapy (CRT) response is lacking. The aim of this study was to evaluate the impact of CRT enhanced by SyncAV on echocardiographic and clinical responses.Methods and Results: Consecutive heart failure (HF) patients from three centers treated with a quadripolar CRT system (Abbott) were enrolled. The total of 122 patients were divided into BiV+SyncAV (n = 68) and BiV groups (n = 54) according to whether they underwent CRT with or without SyncAV. Electrocardiographic, echocardiographic, and clinical data were assessed at baseline and during follow-up. Echocardiographic response to CRT was defined as a ≥15% decrease in left ventricular end-systolic volume (LVESV), and clinical response was defined as a NYHA class reduction of ≥1. At the 6-month follow-up, the baseline QRSd and LVESV decreased more significantly in the BiV+SyncAV than in the BiV group (QRSd −36.25 ± 16.33 vs. −22.72 ± 18.75 ms, P &lt; 0.001; LVESV −54.19 ± 38.87 vs. −25.37 ± 36.48 ml, P &lt; 0.001). Compared to the BiV group, more patients in the BiV+SyncAV group were classified as echocardiographic (82.35 vs. 64.81%; P = 0.036) and clinical responders (83.82 vs. 66.67%; P = 0.033). During follow-up, no deaths due to HF deterioration or severe procedure related complications occurred.Conclusion: Compared to BiV pacing, BiV combined with SyncAV leads to a more significant reduction in QRSd and improves LV remodeling and long-term outcomes in HF patients treated with CRT.
Social Cognition in Patients With Cerebellar Neurodegenerative Disorders
Authors: Tamaš Olivera , Kostić Milutin , Kačar Aleksandra , Stefanova Elka , Ðokić Biljana Salak , Stanisavljević Dejana , Milovanović Andona , Ðorđević Mirjana , Glumbić Nenad , Dragašević-Mišković Nataša 
Published: August 2021

ObjectiveCerebellar neurodegenerative disorders (CDs) are a heterogeneous group of disorders. It is known that the cerebellum plays a role not only in motor, but also in cognitive and social cognitive functions. The aim of this study was to investigate social cognition in patients with different CDs.Materials and MethodsSocial cognition was examined in 34 patients, 12 with spinocerebellar ataxia type 1 (SCA1), 6 with spinocerebellar ataxia type 2 (SCA2), and 16 with idiopathic late onset cerebellar ataxia (ILOCA). All patients were clinically evaluated using the Scale for the Rating and Assessment of Ataxia. In addition, 34 age, sex, and education-matched healthy control (HC) subjects were similarly analyzed. Social cognition was studied using two tests: the Faux Pas Recognition Test and the Reading the Mind in the Eyes Test (RMET). An appropriate array of neuropsychological tests was used to assess the global cognitive status as well as the frontal functions and mood.ResultsCD patients achieved significantly worse results on both tests of social cognition compared to the HCs. The SCA1 + 2 group achieved the poorest results on the Faux Pas Recognition Test and exhibited poor performance on all cognitive tests, but was only significantly worse compared to the ILOCA group on the Free and Cued Selective Reminding Test (FCSRT) – recognition. The patients in the SCA1 + 2 and ILOCA groups obtained similar scores on RMET. In the SCA1 + 2 group the findings significantly correlated with clinical parameters of disease severity and duration and executive functions (EFs), and with mood and executive functions in the ILOCA group. In the SCA group EFs appeared as the only significant predictor of RMET achievement. The Boston Naming Test (BTN) was a significant predictor of the CD patients’ achievement on RMET, while the BTN, the Trail Making Test Part A and FCSRT – Delayed free recall predicted their performance on the Faux Pas Recognition Test.ConclusionPatients with CD have social cognitive impairments as demonstrated by the Faux Pas Test and the RMET test results. The SCA1 and 2 patients exhibited a more pronounced impairment compared with the ILOCA patients. The independent cognitive predictors of social cognition impairment were EFs and language.
Anti-Thymocyte Globulin Prophylaxis in Patients With Hematological Malignancies Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: An Updated Meta-Analysis
Authors: Yang Xue , Li Dongjun , Xie Yao 
Published: August 2021

BackgroundAnti-thymocyte globulin (ATG) prophylaxis reduces graft-versus-host disease (GVHD) incidence. This meta-analysis aimed to explore the long-term efficacy of ATG and the influencing factors in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).MethodsPubMed, Embase, and Cochrane databases were searched for the relevant studies published up to August 2020. Data from randomized controlled trials (RCTs) on ATG prophylaxis for GVHD prevention in allo-HSCT patients were extracted.ResultsA total of eight relevant RCTs (1,348 patients) were included. ATG significantly reduced the incidence of grade III–IV aGVHD (P = 0.001) and cGVHD (P &lt; 0.001). ATG significantly improved the GVHD relapse-free survival (GRFS) (P &lt; 0.001). The immunosuppressive regimen (number and dose of immunosuppressants) was significantly reduced when using ATG (P = 0.005). Epstein-Barr virus (EBV) reactivation was high in patients receiving ATG (P = 0.003). No significant differences were detected in relapses, overall survival (OS), relapse-free survival (RFS), and non-relapse mortality (NRM) between the ATG and no ATG groups. Subgroup analyses revealed that the donor type and ATG formulation might be the possible sources of heterogeneity among the included studies. Meta-regression analysis showed that the cumulative dose of ATG did not affect GVHD, OS, relapse, RFS, and NRM.ConclusionAlthough ATG had no significant effect on relapse, RFS, and NRM, it significantly reduced the occurrence and severity of GVHD, improved the GRFS, and reduced the number and dose of immunosuppressants in patients undergoing allo-HSCT.
An Analysis Based on Molecular Docking and Molecular Dynamics Simulation Study of Bromelain as Anti-SARS-CoV-2 Variants
Authors: Tallei Trina Ekawati , Fatimawali  , Yelnetty Afriza , Idroes Rinaldi , Kusumawaty Diah , Emran Talha Bin , Yesiloglu Talha Zahid , Sippl Wolfgang , Mahmud Shafi , Alqahtani Taha , Alqahtani Ali M. , Asiri Saeed , Rahmatullah Mohammed , Jahan Rownak , Khan Md. Arif , Celik Ismail 
Published: August 2021

The rapid spread of a novel coronavirus known as SARS-CoV-2 has compelled the entire world to seek ways to weaken this virus, prevent its spread and also eliminate it. However, no drug has been approved to treat COVID-19. Furthermore, the receptor-binding domain (RBD) on this viral spike protein, as well as several other important parts of this virus, have recently undergone mutations, resulting in new virus variants. While no treatment is currently available, a naturally derived molecule with known antiviral properties could be used as a potential treatment. Bromelain is an enzyme found in the fruit and stem of pineapples. This substance has been shown to have a broad antiviral activity. In this article, we analyse the ability of bromelain to counteract various variants of the SARS-CoV-2 by targeting bromelain binding on the side of this viral interaction with human angiotensin-converting enzyme 2 (hACE2) using molecular docking and molecular dynamics simulation approaches. We have succeeded in making three-dimensional configurations of various RBD variants using protein modelling. Bromelain exhibited good binding affinity toward various variants of RBDs and binds right at the binding site between RBDs and hACE2. This result is also presented in the modelling between Bromelain, RBD, and hACE2. The molecular dynamics (MD) simulations study revealed significant stability of the bromelain and RBD proteins separately up to 100 ns with an RMSD value of 2 Å. Furthermore, despite increases in RMSD and changes in Rog values of complexes, which are likely due to some destabilized interactions between bromelain and RBD proteins, two proteins in each complex remained bonded, and the site where the two proteins bind remained unchanged. This finding indicated that bromelain could have an inhibitory effect on different SARS-CoV-2 variants, paving the way for a new SARS-CoV-2 inhibitor drug. However, morein vitroandin vivoresearch on this potential mechanism of action is required.
Case Report: Rehabilitation After Platelet-Rich Growth Factors’ Intra-Articular Injections for Knee Osteoarthritis: Two Case Reports of a Home-Based Protocol
Authors: Negrini Francesco , De Lucia Francesco , Negrini Stefano , Tornese Davide , Facchini Francesca , Vecchio Michele , de Girolamo Laura 
Published: August 2021

Knee osteoarthritis (KOA) is a chronic progressive disease that can cause pain, functional impairment, and ultimately disability. A novel and promising therapeutic approach to KOA is the so-called regenerative medicine, a set of procedures designed to harness tissue regenerative capacity and optimize functional recovery. Increasing evidence points out that platelet-rich plasma (PRP) intra-articular injections can decrease pain and improve functional abilities in KOA patients. In the present case reports, we analyze two patients who were treated with PRP injections coupled with a posttreatment home-based rehabilitation program. The two patients were selected to represent two different populations: patient 1 was an 85-year-old with severe impairment of functional abilities, while patient 2 was a younger (59 years old) and more active patient. The protocol consisted in a series of exercise to be performed at home, during the five days following PRP injection for two consecutive weeks (10 days in total). The exercises were designed to reduce the inflammation after the injection, enhance the proprioceptive control of the treated lower limb, and strengthen hip and knee flexors and extensors, mainly by isometric work. Results were evaluated at two time points: before and 2 months after the first PRP injection. The outcomes considered were as follows: visual analog scale for pain, EuroQol 5 dimensions questionnaire, Tegner Activity Scale for functioning, and Knee Injury and Osteoarthritis Outcome Score (KOOS). Both patients did not report any side effects from the treatment. Improvement in patient 1 was drastic at the two months follow-up as far as pain and functional abilities are concerned. Patient 2’s improvement was less evident, probably due to the higher starting point in both pain and functionality. Overall, the developed program seemed safe and was tolerated by the patients analyzed in the study, who performed it with good compliance.
Reference Values and Related Factors for Peak Expiratory Flow in Middle-Aged and Elderly Chinese
Authors: Ji Chao , Xia Yang , Dai Huixu , Zhao Zhiying , Liu Tiancong , Tong Shuhui , Zhang Xiaohang , Zhao Yuhong 
Published: August 2021

Background: Peak expiratory flow (PEF), as an essential index used for screening and monitoring asthma, chronic obstructive pulmonary disease, and respiratory mortality especially in the elderly, is recommended for low-resource settings in low- and middle-income countries. However, few studies have focused on the reference of PEF in China, especially in middle-aged and elderly people. Thus, this study aimed to determine age- and sex-specific reference values of PEF in the middle-aged and elderly Chinese population.Methods: There were 8,914 participants who were included for risk factor analysis and 5,498 participants included for reference value analysis. The PEF was measured using a peak flow meter in liters per minute. The distributions of standardized PEF terciles stratified by sex and age were reported. Multiple linear regression analysis was used to determine the associations between risk factors and PEF.Results: The PEF was higher in men than women across all age subgroups. The value of PEF decreased with age in both men and women. Height, weight, handgrip strength, and residence in rural were positively associated with PEF. Age and smoking status were negatively associated with PEF significantly in both men and women (P &lt; 0.05). The mean PEF values were 367.10 and 253.00 L/min for men and women, respectively. Meanwhile, the prevalence of low PEF was 3.94 and 3.32% for men and women, respectively.Conclusions: Age- and sex-specific centiles of standardized PEF for the middle-aged and elderly Chinese population were estimated. The reference values for low PEF could provide reference standards for epidemiological studies and clinical practices in the future. Interventions to improve lung functions or to prevent respiratory disease should be paid more attention to factors associated with PEF.
Lessons Learned From COVID-19 Contact Tracing During a Public Health Emergency: A Prospective Implementation Study
Authors: Shelby Tyler , Schenck Christopher , Weeks Brian , Goodwin Justin , Hennein Rachel , Zhou Xin , Spiegelman Donna , Grau Lauretta E. , Niccolai Linda , Bond Maritza , Davis J. Lucian 
Published: August 2021

Background: Contact tracing is a core element of the public health response to emerging infectious diseases including COVID-19. Better understanding the implementation context of contact tracing for pandemics, including individual- and systems-level predictors of success, is critical to preparing for future epidemics.Methods: We carried out a prospective implementation study of an emergency volunteer contact tracing program established in New Haven, Connecticut between April 4 and May 19, 2020. We assessed the yield and timeliness of case and contact outreach in reference to CDC benchmarks, and identified individual and programmatic predictors of successful implementation using multivariable regression models. We synthesized our findings using the RE-AIM implementation framework.Results: Case investigators interviewed only 826 (48%) of 1,705 cases and were unable to reach 545 (32%) because of incomplete information and 334 (20%) who missed or declined repeated outreach calls. Contact notifiers reached just 687 (28%) of 2,437 reported contacts, and were unable to reach 1,597 (66%) with incomplete information and 153 (6%) who missed or declined repeated outreach calls. The median time-to-case-interview was 5 days and time-to-contact-notification 8 days. However, among notified contacts with complete time data, 457 (71%) were reached within 6 days of exposure. The least likely groups to be interviewed were elderly (adjusted relative risk, aRR 0.74, 95% CI 0.61–0.89, p = 0.012, vs. young adult) and Black/African-American cases (aRR 0.88, 95% CI 0.80–0.97, pairwise p = 0.01, vs. Hispanic/Latinx). However, ties between cases and their contacts strongly influenced contact notification success (Intraclass Correlation Coefficient (ICC) 0.60). Surging caseloads and high volunteer turnover (case investigator n = 144, median time from sign-up to retirement from program was 4 weeks) required the program to supplement the volunteer workforce with paid public health nurses.Conclusions: An emergency volunteer-run contact tracing program fell short of CDC benchmarks for time and yield, largely due to difficulty collecting the information required for outreach to cases and contacts. To improve uptake, contact tracing programs must professionalize the workforce; better integrate testing and tracing services; capitalize on positive social influences between cases and contacts; and address racial and age-related disparities through enhanced community engagement.