bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accumulation of HIV-1 Drug Resistance Mutations and Methamphetamine Use
Authors: Truong Hong-Ha M. , Fatch Robin , Deeks Steven G. , Krone Melissa , Martin Jeffrey N. , Hunt Peter W. , Lum Paula J. 
Published: June 2021

Background:
Antiretroviral therapy (ART) non-adherence and methamphetamine use
are associated with higher HIV drug resistance prevalence. How they affect drug resistance mutations
accumulation is less studied.

Objective:
We assessed factors associated with drug resistance mutations accumulation.

Methods:
We evaluated HIV chronically-infected patients from a clinic-based research cohort on
first-line ART regimens with genotype results within 30 days of baseline. Methamphetamine use
and ART adherence were self-reported at each study visit. High ART adherence was defined as
0-5% missed doses in the last 30 days.

Results:
One-hundred twenty-five patients contributed 496 study visits. At baseline, 81% of patients
reported high ART adherence; 90% reported no methamphetamine use in the prior 4 months,
8% used monthly or less and 2% used daily or weekly. Methamphetamine users and non-users had
similarly high ART adherence (p=0.93). Adjusted incidence rate ratio (aIRR) of drug resistance mutations
accumulation was 2.04 (95% CI 0.64, 6.46) for daily/weekly users and 1.71 (95% CI 0.66,
4.42) for patients with monthly or less users, compared to non-users. aIRR was 0.71 (95% CI 0.44,
1.15) with >5-10% missed ART doses and 1.21 (95% CI 0.80, 1.83) with >10% missed doses compared
to 0-5% missed doses.

Conclusions:
We found no strong evidence for the effect of methamphetamine use and ART adherence
on drug resistance mutations accumulation. Research cohort patients may have been more engaged
in care and treatment adherent than non-cohort patients. Our findings suggest methamphetamine
use might not lead to treatment failure among HIV patients who are otherwise engaged in
care.
DEVELOPMENT AND VALIDATION OF ULTRAVIOLET–VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF GLYCYRRHIZIN IN METHANOLIC EXTRACT OF GLYCYRRHIZA GLABRA L
Authors: HYDER IMRAN , NASEER ARIF , AHMAD ADIL 
Published: June 2021

Objective: The pure form of glycyrrhizin was bought from Yucca Enterprises, Mumbai-37, India. The pure form of drug used in treatment of acne vulgaris disease. Pharmacognostical studies of Glycyrrhiza glabra L. indicated surprising antibacterial action against Propionibacterium acnes.
Methods: A simple, rapid, accurate, precise, and economic spectrophotometric technique for estimation of glycyrrhizin in methanolic extract of G. glabra L. have been developed. Glycyrrhizin exhibit absorbance most at 254 nm when phosphate buffer (pH-6.8) methanol is used as solvent in 70:30 proportion, so absorbance was once measured at the identical wave lengths for the determination of glycyrrhizin. Glycyrrhizin obeys the Beer Lambert’s law in the concentration range of 4–24 μg/ml.
Results: This method was validated according to International Council for Harmonization guidelines and can be adopted for the general analysis of glycyrrhizin in hydroalcoholic extract of G. glabra. The approach is simple, rapid, safe, accurate, affordable, and beneficial for standardization of the licorice products.
Conclusion: The results applied in the routine analysis and quality control of pharmaceutical dosage forms containing glycyrrhizin.
A RANDOMISED CONTROL TRIAL ON CEREBRO VASCULAR ACCIDENT PATIENTS WITH REFERENCE TO AETIOLOGY AND MANAGEMENT: 24 WEEKS, SINGLE-CENTER, PROSPECTIVE OBSERVATIONAL PILOT STUDY
Authors: K LEELA PRASAD , KAREEMULLA SHAIK , K ALIYA FIRDOSE , S YASMEEN 
Published: June 2021

Objectives: Stroke is one of the leading causes of death and long-term disability in world. Stroke is an important cause of premature death and disability in low-income and middle-income countries like India, largely driven by demographic changes and enhanced by the increasing prevalence of key modifiable risk factors. The main aim of our study was to assess the clinical profile with special reference to the etiology of the condition, the management, and drug utilization review.
Methods: This is a hospital-based prospective observational randomized control trial which was conducted for a period of 6 months at Government General Hospital, Rajiv Gandhi Institute of Medical Sciences, Kadapa. Seventy-five patients were recruited based on study criteria. The data were analyzed and summarized as frequency and percentage by GraphPad Prism software using Microsoft Excel.
Results: In a total of 75 patients, it was found that 45 and 30 patients were female. Maximum number of patients (i.e. 36 patients) belonged to 51–60 years age group. We observed that 52 patients were suffering from ischemic stroke, 21 patients were suffering from transient ischemic stroke, and only 2 patients were suffering from ischemic stroke and transient ischemic stroke. Among 75 patients studied, hypertension (62%), diabetes mellitus (28%), smoking (33%), and alcohol (33%) were the risk factors.
Conclusion: In this study, ischemic stroke was most prevalent. Hypertension, that is, increase of blood pressure considered as one of the important and major risk factors for stroke occurrence and recurrence. Proper management includes non-pharmacological (physiotherapy) along with pharmacological treatment that included cardiovascular system drugs such as hypolipidemics, cognition enhancers, anticoagulants, and antihypertensive therapy.
DRUG UTILIZATION AND PRESCRIBING PATTERN ANALYSIS IN ORTHOPAEDIC OUTPATIENT DEPARTMENT OF TERTIARY CARE HOSPITAL
Authors: K DHIVYA , SHANKARI R SHIVA , ZULKARNANE A MOHAMMED , R GAUTAM 
Published: June 2021

Objective: The objective of conducting prescribing pattern study is to monitor, evaluate, and if necessary, recommend modifications in the prescribing behavior of medical practitioners. Hence, this study was conducted to analyze the drug utilization and prescribing pattern of drugs in orthopedic outpatient department (OPD).
Methods: This prospective observational study was conducted in the orthopedic OPD of tertiary care hospital for a period of 3 months. Data were obtained from the prescriptions through one-to-one interviews and recorded in a separately designed case report form.
Results: Out of the 260 patients enrolled in the study, 181 were female and 79 were male. The patients between the ages of 50 and 60 years constituted the higher number with a mean age of 52.2 years. The total number of drugs prescribed in the analyzed prescriptions was 1012 which includes orthopedic drugs as well as drugs prescribed to treat various comorbidities. The World Health organization drug prescribing indicators were used to assess the appropriate use of drugs.
Conclusion: Our study concludes that drug utilization and prescribing quality should be improved by promoting medical education on current updates. The periodic audit should be conducted by a clinical pharmacist to reduce an error in the prescription as well as to check the compliance of prescription with standard treatment guidelines for rationalizing the therapy.
A STUDY OF THE POTENTIATING EFFECT OF TOPICAL PROPARACAINE 0.5% ON TROPICAMIDE 0.8% AND PHENYLEPHRENE 5% INDUCED MYDRIASIS IN A SOUTHINDIAN POPULATION
Authors: CHELLAKUMAR VIKRAM , RAVINDRAN DHARSHINI 
Published: June 2021

Objectives: Pupillary dilatation is an integral part of comprehensive ophthalmic examination. It is also essential for cataract surgery and outpatient laser procedures. Rapid and sustained dilatation is often required. It has been proposed that prior instillation of proparacaine 0.5% can potentiate the effect of the routinely used tropicamide 0.8% phenylephrine 5% combination mydriatic agent. However, certain studies have shown that it is not effective in dark colored iris as compared to light colored iris; hence, this study was done on a predominantly South Indian population with dark iris.
Methods: Hundred eyes of 50 patients requiring pupillary dilatation as part of routine ophthalmic evaluation were included in the study. The patients were divided into two groups. The study group was given 0.5% proparacaine before instillation of mydriatic agent and the control group was given only tropicamide 0.8% and phenylephrine 5% eye drops. Pupillary dilatation was measured after 15 min and 30 min in both eyes. The end point was taken as 6 mm pupillary dilatation.
Results: There was a statistically significant difference in the rate of pupillary dilatation between the control and the study group at 15 min and 30 min after instillation of eye drops.
Conclusion: The study concluded that prior instillation produced faster dilatation even in patients with dark colored iris; hence, we suggest the use of topical anesthetic proparacaine 0.5% in situations where rapid mydriasis is required.
Reflexiones sobre la enseñanza universitaria en el Area de la salud en tiempos de pandemia
Authors: Casnati Ana María 
Published: June 2021

La pandemia de COVID 19 que desde el 13 de marzo de 2020 se ha instalado en Uruguay ha generado un cambio sustancial en todos los niveles de enseñanza. Particularmente en la Universidad de la República se debieron adaptar todos los cursos a la modalidad virtual o remota, logrando así la implementación y el desarrollo de la mayoría de los mismos...
Circulating Thrombospondin-2 as a Novel Fibrosis Biomarker of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes
Authors: Lee Chi-Ho , Seto Wai-Kay , Lui David Tak-Wai , Fong Carol Ho-Yi , Wan Helen Yilin , Cheung Chloe Yu-Yan , Chow Wing-Sun , Woo Yu-Cho , Yuen Man-Fung , Xu Aimin , Lam Karen Siu-Ling 
Published: June 2021

OBJECTIVE
Preclinical studies have suggested that thrombospondin-2 (TSP2) is implicated in liver fibrosis. However, the clinical relevance of TSP2 in nonalcoholic fatty liver disease (NAFLD) remains undefined. Here, we investigated the cross-sectional and longitudinal associations of circulating TSP2 levels with advanced fibrosis (F3 or greater [≥FE] fibrosis) in NAFLD.

RESEARCH DESIGN AND METHODS
Serum TSP2 levels were measured in 820 patients with type 2 diabetes and NAFLD. All participants received vibration-controlled transient elastography (VCTE) at baseline to evaluate their hepatic steatosis and fibrosis using controlled attenuation parameter (CAP) and liver stiffness (LS) measurements, respectively. Among those without advanced fibrosis at baseline, reassessment VCTE was performed to determine whether ≥F3 fibrosis had developed over time. Multivariable logistic regression analysis was used to evaluate the cross-sectional and longitudinal associations of serum TSP2 level with ≥F3 fibrosis.

RESULTS
Baseline serum TSP2 level was independently associated with the presence of ≥F3 fibrosis (odds ratio [OR] 5.13, P &lt; 0.001). The inclusion of serum TSP2 level significantly improved the identification of ≥F3 fibrosis by clinical risk factors. Over a median follow-up of 1.5 years, 8.8% developed ≥F3 fibrosis. Baseline serum TSP2 level was significantly associated with incident ≥F3 fibrosis (OR 2.82, P = 0.005), independent of other significant clinical risk factors of fibrosis progression, including BMI, platelet count, and CAP at baseline.

CONCLUSIONS
Circulating TSP2 level was associated with both the presence and the development of advanced fibrosis and might be a potentially useful prognostic biomarker for the development and progression of liver fibrosis in patients with type 2 diabetes and NAFLD.
Dashboard Visualisation for Healthcare Performance Management: Balanced scorecard method
Authors: Victor Stephen , Farooq Ayesha 
Published: June 2021

Objective: The increase in demand for hospitalisation in an environment of financial stress has hastened the quest for more efficient healthcare delivery systems. In the past performance management methodologies in the healthcare sector have been predominantly static resulting in a lack of consistency, comparability and timeliness. To mitigate these shortcomings this research work has attempted to create a conceptual framework in the digital dashboard format.
Setting: Of the frameworks presently used, the Balanced Scorecard(BSC) is very popular, primarily because the BSC is a management system (not just a measurement system) that helps an organization highlight its vision and translate them into action.
Design: The design adopted in this research work is primarily qualitative and exploratory. The methodology includes collating KPIs from published literature, crystallising them using the Delphi Method and applying the Likert-scale to prioritise them. To facilitate visualisation of the prioritised KPIs in the BSC format, the construction of a digital dashboard was envisaged.
Results: A dynamic dashboard was created in the BSC format with three Key Performance Indicators(KPI) for each of the four perspectives.

Financial: Return on assets, average daily collections and working capital ratio
Customer Perspective: Patient satisfaction, lost business – number of appointments not attended and percentage of patients Leaving Against Medical Advice(LAMA)
Internal Processes: Billing and collections/posting time, emergency patients triaged within 15 minutes of arrival and patient waiting time
Learning And Growth: Empowerment (decision-making & participation), employee satisfaction and strategic alliances/partnerships
A Focussed Literature Review of Power and Influence Leadership Theories
Authors: Olley Richard 
Published: June 2021

This Narrative Theoretical Literature Review relates to the evolution and translation of two contemporary leadership theories and anchors these to a leadership theory framework that demonstrates where they fit within the leadership theory body of knowledge.
This literature review was an integral part of the preparation for a mixed-methods study related to leadership in the aged care sector which has successfully concluded and one of the major findings of that yet unpublished study is that the followership is positively influenced in their work performance with a reduced turnover intention if they considered that their leader was authentic and ethical. Authentic and ethical leadership appear to be escalating in importance and translatability to the health and social care environments struggling with unmet workforce demands and high consumer expectations.
The review contains a description and timeline of the development of each of the theories included. This literature review is useful for investigating either or both leadership theories or their application to health and social care or designing leadership training programs or leader performance assessment tools.
“HOW DO YOU GRIEVE A NUMBER?” – UNSUCCESSFUL GRIEVING IN JESS WALTER’S “THE ZERO”
Authors: PRECUP Amelia 
Published: June 2021

“How do you grieve a number?” – Unsuccessful Grieving in Jess Walter’s The Zero. Accountability and grief, assuming different forms and accommodating a variety of (sometimes antithetical) approaches, seem to be the dominants shaping 9/11 fiction and, consequently, the attendant criticism. Grief is a central theme to Jess Walter’s The Zero, examined in various manifestations, ranging from public to private, from counterfeit to genuine. The claim of this paper is that The Zero explores alternatives of grief only to invite the thought that the work of mourning, in a traditionally ‘successful’ sense, is no longer possible post-9/11.
REZUMAT. “Cum deplângem un număr?” – Eșuarea travaliului de doliu în romanul The Zero de Jess Walter. Luând diverse forme și permițând o plajă largă de abordări, uneori chiar antitetice, identificarea responsabililor și gestionarea suferinței par a fi dominantele care modelează proza despre atacurile teroriste de la 11 septembrie și, implicit, critica aferentă. Raportarea la suferință și doliu este tema centrală a romanului The Zero de Jess Walter, examinată în multiplele-i manifestări, traversând spațiul public și spațiul privat, teritorii ale superficialității, dar și zone restrânse de autenticitate. În acest context, lucrarea de față susține că romanul The Zero explorează alternative de raportare la suferință și doliu pentru a lansa ideea că travaliul de doliu, în accepțiunea tradițională a succesului acestui proces, nu mai este posibil în lumea de după 11 septembrie.
Cuvinte-cheie: literatură 9/11, deplângere și suferință, travaliul de doliu, narațiune a traumei, Jess Walter
ANALISIS KEMITRAAN ANTAR PEMANGKU KEPENTINGAN DALAM MENINGKATKAN KEUNGGULAN BERSAING INDUSTRI KERAMIK: STUDI PADA SENTRA INDUSTRI KERAMIK PLERED PURWAKARTA, INDONESIA
Authors: Raharja Sam'un Jaja , Arifianti Ria , - Rivani 
Published: June 2021

Strategic partnerships amongst stakeholders need to be done to improve competitive advantage for the Purwakarta Plered ceramics industry. The purpose of this study was to analyze perceptions about the partnership of industry players with other partners in the Purwakarta Plered Ceramic Industry in Indonesia. The research method used was a quantitative method with survey research type. The population in this study were 229 industry players of Plered ceramics industry. Data collection techniques were carried out through the distribution of questionnaires to 75 people as respondents taken by simple random sampling. The results showed that the perception of the actors in the partnership relationship with partners in the development of the ceramic industry in Plered Purwakartta was going well. This indicates that so far the partnership that has been built so far has been going well. To maintain and enhance closer partnerships between industry players and other partners, effective communication and information sharing need to be improvedKemitraan strategis antar pemangku kepentingan perlu dilakukan untuk meningkatkan keunggulan bersaing bagi industri keramik Plered Purwakarta. Tujuan penelitian ini adalah untuk menganalisis persepsi tentang kemitraan para pelaku industri terhadap mitra lainnya pada industri Keramik Plered Purwakarta Indonesia. Metode penelitian yang digunakan adalah metode kuantitatif dengan jenis penelitian survai. Populasi dalam penelitian ini adalah para pelaku industri keramik Plered sebanyak 229 pelaku industri. Teknik pengumpulan data dilakukan melalui penyebaran kuesioner kepada 75 orang sebagai responden yang diambil secara acak sederhana (simple random). Hasil penelitian menunjukkan persepsi para pelaku dalam hubungan kemitraan dengan mitra dalam pengembangan industri keramik di Plered Purwakartta sudah berjalan dengan baik. Hal ini menandakan bahwa selama ini kemitraan yang sudah terbangun selama ini berjalan dengan baik. Untuk mempertahankan dan meningkatkan kemitraan yang lebih erat antar pelaku industri dan juga mitra lainnya perlu peningkatan komunikasi secara efektif dan saling berbagi informasi.
IDENTIFIKASI AKTOR DAN FAKTOR DALAM EKOSISTEM KEWIRAUSAHAAN : KASUS PADA INDUSTRI KREATIF DI WILAYAH PRIANGAN TIMUR, JAWA BARAT
Authors: Purbasari Ratih , Wijaya Chandra , Rahayu Ning 
Published: June 2021

This study aims to identify actors and factors involved in the process of knowledge transfer through various networks in the entrepreneurial ecosystem, by taking the case of the creative industry in the East Priangan region which is recognized as having competitive advantages. This identification is important to determine the actors and factors involved in the creative industry entrepreneurial ecosystem in the East Priangan region as an effort to improve the quality of entrepreneurship. The research method used is a qualitative approach and contextual techniques regarding knowledge transfer with the stages (1) Collecting secondary data through literature review (2) Understanding the concept of entrepreneurial ecosystems and creative industries (3) Identifying actors and factors that play a role in the entrepreneurial ecosystem and their analysis. Data collection was carried out by in-depth interview observation. From the research results identified social community actors (surrounding communities) as the most important actors in the entrepreneurial ecosystem and supporting service factors are factors that are incompatible with the entrepreneurial ecosystem model that is the reference in this study. Penelitian ini bertujuan untuk mengidentifikasikan aktor dan faktor yang terlibat dalam proses transfer pengetahuan melalui berbagai jaringan yang ada di dalam ekosistem kewirausahaan, dengan mengambil kasus pada industri kreatif di wilayah priangan timur yang diakui telah memiliki keunggulan daya saing. Identifikasi ini penting dilakukan untuk mengetahui aktor dan faktor yan terlibat dalam ekosistem kewirausahaan industri kreatif di wilayah Priangan Timur sebagai upaya peningkatan kualitas kewirausahaan. Metode penelitian yang digunakan adalah pendekatan kualitatif dan teknik kontekstual mengenai transfer pengetahuan dengan tahapan (1) Mengumpulkan data sekunder melalui tinjauan pustaka, (2) Pemahaman konsep ekosistem kewirausahaan dan industri kreatif, dan (3) Identifikasi aktor dan faktor yang berperan dalam ekosistem kewirausahaan dan analisisnya. Pengumpulan data dilakukan dengan observasi dan wawancara mendalam. Dari hasil penelitian diidentifikasikan aktor masyarakat sosial (masyarakat sekitar) sebagai aktor yang paling berperan di dalam ekosistem kewirausahaan, serta faktor layanan pendukung merupakan faktor yang tidak sesuai dengan model ekosistem kewirausahaan yang menjadi acuan pada penelitian ini.
PENGARUH MODAL SOSIAL TERHADAP KEMAMPUAN INOVASI SERTA HUBUNGANNYA DENGAN KAPABILITAS INOVASI RADIKAL DAN LOKAL (STUDI PENDAHULUAN PADA PERUSAHAAN TERBUKA DI INDONESIA)
Authors: Budiarti Isniar 
Published: June 2021

Organizational knowledge as social capital emphasizes that knowledge is utilized through various approaches within the company. Intellectual capital is a collection of knowledge that a company uses to gain a competitive advantage. The purpose of this study was to test the hypothesis on the influence of the human capital and organizational variables on radical and local innovation capabilities. Data collection in this longitudinal study was carried out at two different times with a questionnaire return rate of 43% in the first stage and 51% in the second stage. The research sample is a group of top managers and groups of middle and lower managers of public companies in Indonesia. This research is a quantitative study using confirmatory factor analysis (CFA) method with Lisrel 8.8 software. The brief results of this study provide a fundamental foundation as well as explain the relationship between various aspects of intellectual capital both humans and organizations and their relationship with various types of ability to innovate. Pengetahuan organisasi sebagai modal sosial menekankan bahwa pengetahuan dimanfaatkan lewat beragam pendekatan dalam perusahaan. Modal intelektual juga sebagai kumpulan pengetahuan yang dimanfaatkan perusahaan guna memperoleh keunggulan bersaing. Tujuan penelitian ini adalah untuk menguji hipotesis atas pengaruh pada variabel modal manusia dan organisasi tehadap kapabilitas inovasi radikal dan lokal. Pengumpulan data pada penelitian longitudinal ini dilakukan pada dua waktu yang berbeda dengan tingkat pengembalian kuisioner 43% pada tahap pertama dan 51 % pada tahap kedua. Sampel penelitian adalah kelompok manajer puncak dan kelompok manajer menengah dan manajer bawah perusahaan terbuka di Indonesia. Penelitian ini merupakan penelitian kuantitatif menggunakan metode Confirmatory Factor Analysis (CFA) dengan perangkat lunak Lisrel 8.8. Hasil singkat dari penelitian ini memberikan pondasi mendasar sekaligus menjelaskan hubungan berbagai aspek modal intelektual baik manusia dan organisasi serta hubungannya dengan berbagai jenis kemampuan untuk melakukan inovasi.