bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing Research Engagement among Medical students in the United Kingdom (REMED-UK): protocol for a prospective, observational, national, multi-centre questionnaire - study
Authors: Osunronbi Temidayo , Adeboye William , Faluyi David , George Jasmine , Sofela Agbolahan 
Published: April 2021

Abstract
Introduction: There has been a decline in the number of academic clinicians in the UK. Also, there are gender and ethnic inequalities in research opportunities amongst UK clinicians. The decision to get involved in research as a clinician is usually made as a medical student. Hence, this study aims to investigate the factors affecting UK medical students’ involvement in research, and to understand their perceptions of research, motivation for and the barriers to their engagement in research. Methods: This study is a prospective, observational, national, multi-centre study that will utilise an online questionnaire using the QualtricsTM survey tool. Medical students that are at least 18 years old and enrolled in a UK medical school in the 2020/21 academic year are eligible to partake in this study. The following data will be collected: demographic, research experience, research perception, research self-efficacy, motivation, and barriers to engaging in research. The outcome measures are: number of research projects, publications, presentations, and successful grant applications.Conclusion: This study will produce evidence-based reports that will guide UK medical schools and relevant organisations in developing resources and programmes that will increase the number of future academic clinicians and resolve inequalities in research opportunities and engagement amongst future clinicians.
SINE jumping contributes to large-scale polymorphisms in the pig genomes
Authors: Chen Cai , D'Alessandro Enrico , Murani Eduard , Zheng Yao , Giosa Domenico , Yang Naisu , Wang Xiaoyan , Gao Bo , Li Kui , Wimmers Klaus , Song Chengyi 
Published: April 2021

Abstract
Background: Molecular markers based on retrotransposon insertion polymorphisms (RIPs) have been developed and are widely used in plants and animals. Short interspersed nuclear elements (SINEs) exert wide impacts on gene activity and even on phenotypes. However, SINE RIP profiles in livestock remain largely unknown, and not be revealed in pigs. Results: Our data revealed that SINEA1 displayed the most polymorphic insertions (22.5% intragenic and 26.5% intergenic), followed by SINEA2 (10.5% intragenic and 9% intergenic) and SINEA3 (12.5% intragenic and 5.0% intergenic). We developed a genome-wide SINE RIP mining protocol and obtained a large number of SINE RIPs (36,284), with over 80% accuracy and an even distribution in chromosomes (14.5/Mb), and 74.34% of SINE RIPs generated by SINEA1 element. Over 65% of pig SINE RIPs overlap with genes, with significant enrichment in the first and second introns of protein-coding and long non-coding RNA genes. Nearly half of the RIPs are common in these pig breeds. Sixteen SINE RIPs were applied for population genetic analysis in 23 pig breeds, the phylogeny tree and cluster analysis were generally consistent with the geographical distributions of native pig breeds in China. Conclusions: Our analysis revealed that SINEA1–3 elements, particularly SINEA1, are high polymorphic across different pig breeds, and generate large-scale structural variations in the pig genomes. And over 35, 000 SINE RIP markers were obtained. These data indicate that young SINE elements play important roles in creating new genetic variations and shaping the evolution of pig genome, and also provide strong evidences to support the great potential of SINE RIPs as genetic markers, which can be used for population genetic analysis and quantitative trait locus (QTL) mapping in pig.
Comparing the Experiences of Parturient Women With Remifentanil Analgesia and Elective Cesarean Section and Providing Improver Strategies: A Sequential Explanatory Mixed Method Study
Authors: dousti rana , Hakimi Sevil , Pourfathi Hojjat , Nourizadeh Roghayeh , jahdi Niloufar sattarzadeh 
Published: April 2021

Abstract
Background Identifying methods that can effectively and safely improve the childbirth experience and are tailored to mothers' needs are of crucial importance. The current study aimed to compare experiences of parturient women with remifentanil analgesia and elective cesarean section and providing improver strategies for women living in the city of Tabriz, Iran.MethodsThis is a mixed-method study with an explanatory sequential approach. The first stage is quantitative and longitudinal. The study population is all parturient women who will give birth by elective C-section or vaginal painless delivery using remifentanil in private hospitals of the city of Tabriz in 2020-2021. All mothers are free to choose either method. Participants will be selected from all private hospitals using the convenience sampling technique proportioned to the number of eligible women in each hospital. Participants will be followed up to 30 days after delivery to complete the Edinburgh Postpartum Depression questionnaire. The second stage is a qualitative study aimed at exploring the perceptions of parturient women who had either elective C-section or painless delivery (using remifentanil), including factors related to labor experiences. Data will be collected by semi structured interviews with new mothers and important others (if needed).In the third stage, a mixed study will be performed to provide strategies for improving labor experiences. we will use an explanatory Sequential approach in order to increase the accuracy and quality of data and to use the findings to evaluate different methods of delivery.DiscussionBy comparing the experience of parturient women receiving Remifentanil analgesia and elective C-section, evidence-based improving strategies using a culturally sensitive approach can be provided. Presentation of the results obtained from this study using the mixed method may help in better understanding the issue. Also, the obtained results can be used to enhance the quality of midwifery care to be examined by health policymakers and planners.Trial registrationThis study is approved by the ethics committee of the Tabriz University of Medical Sciences (code: IR.TBZMED.REC.1399. 521). Besides, it's evaluated by relevant refers.
Analysis of Multimodal Imaging Characteristics of Transient Central Retinal Artery Occlusion
Authors: An Weiting , Zhao Qi , Han Jindong 
Published: April 2021

Abstract
Background To observe and analyze the multimodal imaging characteristics of transient central retinal artery occlusion (T-CRAO). Methods Retrospective observational study. Eight patients (8 eyes) diagnosed as T-CRAO in Tianjin Medical University Eye Hospital were included in this study. There were 6 males (6 eyes) and 2 females (2 eyes) with an average age of 63.8 years (38-78years). The clinical manifestation was acute vision loss. All patients underwent best corrected visual acuity (BCVA), slit lamp microscope, color fundus photography (CFP), fundus fluorescein angiography (FFA), optical coherence tomography (OCT) and OCT angiography (OCTA). The clinical data and multimodal imaging characteristics of patients were analyzed. Results There were 4 eyes with BCVA from 0.05 to 0.1 and 4 eyes from 0.1 to 0.3. CFP demonstrated multiple patchy “cotton-wool spot”-like lesions in posterior pole, without typical cherry-red spot. FFA manifested as sluggish filling of arteries, filling front, and delayed filling of vein. The filling was completed within 5 to 10 seconds. The “cotton-wool spot”-like lesions showed low fluorescence in early stage. Some lesions filled gradually; others still showed low fluorescence in late stage. OCT showed inner layer and local nerve fiber layer of retina was thickened. The reflexes of lesions were enhanced intermittently, especially the “hump-like” change of inner nuclear layer (INL). OCTA revealed the vascular density (VD) of superficial capillary plexus (SCP) and deep capillary plexus (DCP) of retina was decreased, the shape of the arcade was damaged, and the foveal avascular zone (FAZ) area was enlarged. En-face image showed isolated patchy hyperreflective lesions at SCP and fused patchy hyperreflective lesions at DCP.Conclusions CFP demonstrated multiple patchy “cotton-wool spot”-like lesions in posterior pole; OCTA revealed decreased VD of SCP and DCP. After treatment, the “cotton-wool spot”-like lesions gradually vanished, and the VD partially recovered.
Suitability of Pedigree Method for Improving Seed Cotton Yield and Fiber Quality Traits
Authors: Younas Abia , Illahi Farrukh , Sarwar Ghulam , Sharif Iram , Chohan Shahid Munir 
Published: April 2021

Abstract
Background: Cotton is grown around the globe for its fiber, which consists of unicellular seed trichome. Converging decent fiber quality and good fiber yield in cotton varieties is crucial for textile industry of any country. Pedigree method is mostly used for developing cotton varieties in Pakistan. Suitability of pedigree method for developing cotton variety is accessed in an experiment. Genotypic variance, phenotypic variance, heritability, co-heritability, genetic advance, mean comparison and correlation analysis was carried out of nine breeding lines of in fifth filial generation. Gene action was thus determined to target the traits for further yield and quality improvement of cotton fiber. Results: Substantial genetic variability existed in F5 lines. Genotypic and phenotypic variances had less differences and phenotypic variances were higher than genotypic variance indicating influence of environment on the final expression of the traits. All traits had medium to high heritability. Seed cotton yield per plant came up with high genetic advance and high heritability indicating additive gene action and can be improved by selection. Mean comparison indicated more variation for GOT% compared to other traits. Correlation analysis indicated selecting more sympodial branches for improving seed cotton yield per plant and selecting more monopodial branches for improving fiber fineness and fiber length. However, co-heritability had high value indicating that all the traits are in balance for improvement. Conclusion: Pedigree method is suitable for improving seed cotton yields and fiber quality. However, statistical check points are recommended with each proceeding generation to apply suitable selection pressure and monitor the gene action for each trait in each generation.
Efficacy of Physical Therapy Interventions on Quality of Life and Upper Quadrant Pain Severity in Women With Post-Mastectomy Pain Syndrome: A Systematic Review and Meta-Analysis
Authors: Kannan Priya , Ying Lam Hiu , Kiu Ma Tsz , Ngai Lo Chiu , Yan Mui Ting , Yan Tang Wing 
Published: April 2021

Abstract
Purpose: To determine the efficacy of physical therapy interventions on quality of life (QoL) and pain severity in women with post-mastectomy pain syndrome (PMPS).Methods: Multiple databases were searched from database inception-October 2020. Randomized controlled trials comparing physical therapy interventions to control were included. Results: Eighteen trials were included in the review. The pooled analysis of the four exercise trials revealed a statistically significant effect of the intervention on general (p=0.001), physical (p=0.044) and mental health components (p=0.027) of QoL, when compared to the control condition. Pooled analysis of data from six exercise trials revealed a significant effect of exercise interventions compared to control on pain severity (p<0.001). Meta-analysis of data from two myofascial release trials showed a significantly greater reduction in pain severity in the intervention group compared to the control group (p=0.04). The pooled analysis of data from two acupuncture trials revealed a significant reduction in pain severity in the intervention group compared to the control group (p=0.003). Pooled analysis of data from two trials revealed a non-significant effect of compression therapy compared to control on pain severity (p>0.05) Conclusion: This review found that exercise is beneficial for improving QoL and alleviating upper quadrant pain severity in women with PMPS. Myofascial release and acupuncture were more effective than the control condition in reducing the pain severity in PMPS. The effect of compression therapy, complex decongestive therapy and neuromuscular taping on PMPS remains inconclusive, and future research is required to validate the effect of these interventions on PMPS.
Perspectives and ethical considerations for return of genetics and genomics research results: a qualitative study of genomics researchers in Uganda
Authors: Ochieng Joseph , Kwagala Betty , Barugahare John , Mwaka Erisa , Ekusai-Sebatta Deborah , Ali Joseph , Sewankambo Nelson K 
Published: April 2021

Abstract
Background: Return of genetics and genomics research results has been a subject of ongoing global debate on what constitutes socially acceptable and ethical approaches for sharing individual and aggregate genomic results with participants. Such feedback to research participants is an ethical requirement to update participants on results related to the study particularly those that are deemed significant. Although there is limited literature, debate continues in the African setting on what constitutes appropriate practice regarding return of results for genetics and genomics research.The study explored the perspectives and ethical considerations of genomics researchers for return of genetics and genomics research results in a Ugandan setting.Methods: This was a qualitative study of researchers in Uganda using semi-structured interview schedules for In-depth interviews. The researchers were purposively selected based on their active involvement in conducting genetics and genomics research in the country. A total of 30 researchers participated in the study and were interviewed on their perspectives and ethical considerations for the return of genetics and genomics research results. Data were analysed through content analysis along the main themes of the study. Content analysis was conducted using a comprehensive thematic matrix, to identify common patterns arising from the narratives. QSR International NVivo software was used to support data analysis. Findings: Return of genetics and genomics research results was generally acceptable to genomics researchers and some researchers had either returned individual or aggregate results. The main reasons for sharing results included actionability, benefits and the clinical utility of the results to the participants. Ethical considerations for appropriate return of results included a need for effective community engagement, genetic counselling prior to disclosure of the results, adequate informed consent and proper assessment of the implications of, or consequences of returning of results. However, the approaches to return of results is not standardised due to lack of ethics and regulatory guidelines to govern the practice in the country.Conclusion: Return of genetics and genomics research results to participants is generally acceptable to genomics researchers and several researchers have returned either individual or aggregate results. Ethical considerations for return of genetics and genomics research results are numerous though their application is not regulated due to lack of appropriate local ethical guidelines.
Walnut Meal Extracts Rich in Polyphenols Mitigate Insulin Resistance and Modulate the Gut Microbiota of High Fat Diet-fed Rats
Authors: He Xingping , Chen Dan , Yang Dingfa , Zhang Xi , Ma Yage , Yang Jingjuan , Chen Chaoyin , Zhao Shenglan 
Published: April 2021

Abstract
Background: This paper aims to investigate the metabolic impact of walnut meal extracts rich in polyphenols (WMP) on high fat diet (HFD)-fed rats and to determine whether the lipid-lowering effects are related to modulations of the gut microbiota. SD rats were fed a standard chow diet or an HFD for 18 weeks. After 6 weeks, the HFD rats were supplemented with 750mg WMP/kg body weight and the vehicle for 12 weeks. The structure of gut microbiota was assessed by analyzing 16S rDNA sequences.Results: WMP suppressed the weight gain and visceral obesity. WMP treatment also improved lipid profiles and increased antioxidative activities. WMP fully reversed hepatic steatosis with upregulation of adipocytokines involved in lipid catabolism (e.g. adiponectin, PPAR-γ, visfatin, CEBPα), and increased the activity of lipoprotein lipase, hormone-sensitive lipase, in which were associated with glucose tolerance improved and insulin resistance mitigated. As revealed by 16S rDNA sequencing, WMP restored the diversity of intestinal flora reduced by HFD, dramatically reduced the abundance of Fusobacterium varium and Enterobacteriaceae, reversed and sharply raised the abundance of Lachnospiraceae UCG005 and Akkermansia decreased by HFD.Conclusion: Our findings demonstrated that WMP suppressed the weight gain and adiposity in HFD-fed rats, and fully reversed HFD diet-induced insulin resistance and hepatic steatosis while dramatically reduced the abundance of Fusobacteriaceae and Enterobacteriaceae, underscoring the gut-liver axis as a primary target of walnut polyphenols.
Energy Mix, Financial Development and Carbon Emissions in China: A Directed Technical Change Perspective
Authors: yao shujie , Zhang Shuai 
Published: April 2021

Abstract
Based on a two-sector (clean energy and dirty energy) model of directed technical change, we examine the relationship between carbon emissions, clean energy consumption and financial development in China using the ARDL method. Clean energy consumption reduces carbon emissions effectively but the effect of financial development is opposite, suggesting that financial development increases carbon emissions, contradicting the findings of many existing studies. Then, we decompose financial sector development on carbon emissions into two different effects: the substitution and income effects. The substitution effect reflects more dirty energy consumption as a result of directed technical change promoted by financial development, leading to more carbon emissions. In contrast, the income effect results in a decline of carbon emissions because financial development enables firms to use more clean energy. The empirical results indicate that the net effect of financial development has caused more carbon emissions. The policy implication is also discussed.JEL: Q01, Q42, Q56
A Qualitative Study of Physicians’ Perceptions and Preferences for Implementing Venous Thromboembolism (VTE) Clinical Practice Guidelines Informed by the Theoretical Domains Framework (TDF)
Authors: Abboud Juliana , Rahman Abir Abdel , Shaikh Niaz , Dempster Martin , Adair Pauline 
Published: April 2021

Abstract
BackgroundThis study used the Theoretical Domains Framework to explore the beliefs and perceptions of physicians to influence the uptake of Venous Thromboembolism prevention guidelines.Methods Semi-structured interviews were conducted with a stratified purposive sample of internal medicine physicians in an acute hospital. The interview topic guide was developed using the Theoretical Domains Framework to identify the factors perceived to influence practice. Two researchers coded the interview transcripts using thematic content analysis. Emerging relevant themes were mapped to TDF domains.Results A total of sixteen medical physicians were interviewed over a six-month period. Nine theoretical domains derived from thirty-three belief statements were identified as relevant to the target behaviour; knowledge (education about the importance of VTE guidelines); beliefs about capabilities (with practice VTE tool easier to implement); beliefs about consequences ( positive consequences in reducing the development of VTE, length of stay, financial burden and support physician decision) and (negative consequence risk of bleeding); reinforcement (recognition and continuous reminders); goals (patient safety goal); environmental context and resources (workload and availability of medications were barriers, VTE coordinator and electronic medical record were enablers); social influences (senior physicians and patient/family influence the VTE practice); behavioural regulation (monitoring and mandatory hospital policy); and nature of the behaviour.Conclusions Using the Theoretical Domains Framework, factors thought to influence the implementation of VTE clinical practice guidelines in the internal medicine department were identified. These factors present theoretically based targets for future interventions.
Detection of Choroidalneovascularization (Cnv) in Retina Oct Images Using Vgg16 and Densenet Cnn
Authors: M.S Abirami , B Vennila , K Suganthi , Kawatra Sarthak , Vaishnava Anuja 
Published: April 2021

Abstract
In this study, we intend to diagnose Choroidal Neovascularization in retinal Optical Coherence Tomography (OCT) images using Deep Learning Architectures. Optical Coherence Tomography (OCT) images can be used to differentiate between a healthy eye and an eye with CNV disease. DenseNet and Vgg16 Architectures of Deep Learning were used in the study and the hyper parameters of both of the architectures were changed to diagnose the disease properly. After the detection of the disease, the diseased OCT images are segmented from the background for the Region of Interest detection using Python OpenCV library that is used for the processing of images. The results of implementation of the Architectures showed that Vgg16 showed better results in detecting the images rather than Dense Net Architecture with an accuracy percentage of 97.53% approximately a percent greater than Dense Net.
WITHDRAWN: Synthesis of Hydrophobic and Hydrophilic Loaded Mesoporous Silica Nanoparticles for Controlled Co-Delivery of Drugs
Authors: K PRIYADHARSINI , M ANBUCHEZHIYAN , K SANGEETHA , N SENGUTTUVAN , SRIBA RAJENDRAN 
Published: April 2021

Abstract
Herein, a biocompatible and nontoxicity novel type of hydrophobic and hydrophilic co-delivery systems based on co-polymer chitosan-graft-PMMA (ch-g-PMMA) modified Mesoporous silica nanoparticles (MSNPs) for cancer therapy was prepared. The pores of MSNPs were loaded with curcumin (CUR) and doxorubicin (DOX) with co-polymer ch-g-PMMA were gated the pores of MSNPs to prevent the release of drugs. These synthesized ch-g-PMMA/MSNPs dual drug-loaded are effectively allowed for co-delivery of drug combinations with improved efficacy. The dual drug loaded MSNPS were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), UV-Visible spectroscopy (UV-Vis), Transmission electron microscope (TEM) and Brunauer–Emmett–Teller (BET) analysis. The TEM and XRD results proved the successful loading of drugs into the pores of hexagonal structure MSNPs with size ~180nm, CUR and DOX were released from the MSNPs only in acid –triggered manner. The cytotoxicity studied were carried out for ch-g-PMMA/MSNPs dual drug-loaded against adenocarcinoma gastric cell line (AGS) shows that MSNPs was highly biocompatible and well suitable for drug carrier.