bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Liberal Prehospital and In‐Hospital Tranexamic Acid Influence Outcome in Severely Injured Patients? A Prospective Cohort Study
Authors: van Wessem Karlijn J. P. , Leenen Luke P. H. 
Published: April 2021

AbstractBackgroundEarly hemorrhage control is important in trauma‐related death prevention. Tranexamic acid (TXA) has shown to be beneficial in patients in hemorrhagic shock, although widespread adoption might result in incorrect TXA administration leading to increased morbidity and mortality.MethodsA 7‐year prospective cohort study with consecutive trauma patients admitted to a Level‐1 Trauma Center ICU was performed to investigate administration of both pre‐ and in‐hospital TXA and its relation to morbidity and mortality. Indication for prehospital and in‐hospital TXA administration was (suspicion of) hemorrhagic shock, and/or systolic blood pressure (SBP) ≤ 90 mmHg. Demographics, data on physiology, resuscitation and outcomes were prospectively collected.ResultsFour hundred and twenty‐two patients (71% males, median ISS 29, 95% blunt injuries) were included. Even though TXA patients were more severely injured with more deranged physiology, no differences in outcome were noted. Overall, thrombo‐embolic complication rate was 8%. In half the patients, hemorrhagic shock was the indication for prehospital TXA, whereas 79% of in‐hospital TXA was given based on suspicion of hemorrhagic shock. Thirteen percent of patients with SBP ≤ 90 mmHg in ED received no TXA at all. Based on SBP alone, 22% of prehospital TXA and 25% of in‐hospital TXA were justified.ConclusionsDespite being more severely injured, TXA patients had similar outcome compared to patients without TXA. Thrombo‐embolic complication rate was low despite liberal use of both prehospital and in‐hospital TXA. Caution should be exercised in selecting patients for TXA, although this might be challenging based on SBP alone in patients who do not yet show signs of deranged physiology on arrival in ED.
Arctic sea ice melt onset favored by an atmospheric pressure pattern reminiscent of the North American-Eurasian Arctic pattern
Authors: Horvath Sean , Stroeve Julienne , Rajagopalan Balaji , Jahn Alexandra 
Published: April 2021

AbstractThe timing of melt onset in the Arctic plays a key role in the evolution of sea ice throughout Spring, Summer and Autumn. A major catalyst of early melt onset is increased downwelling longwave radiation, associated with increased levels of moisture in the atmosphere. Determining the atmospheric moisture pathways that are tied to increased downwelling longwave radiation and melt onset is therefore of keen interest. We employed Self Organizing Maps (SOM) on the daily sea level pressure for the period 1979–2018 over the Arctic during the melt season (April–July) and identified distinct circulation patterns. Melt onset dates were mapped on to these SOM patterns. The dominant moisture transport to much of the Arctic is enabled by a broad low pressure region stretching over Siberia and a high pressure over northern North America and Greenland. This configuration, which is reminiscent of the North American-Eurasian Arctic dipole pattern, funnels moisture from lower latitudes and through the Bering and Chukchi Seas. Other leading patterns are variations of this which transport moisture from North America and the Atlantic to the Central Arctic and Canadian Arctic Archipelago. Our analysis further indicates that most of the early and late melt onset timings in the Arctic are strongly related to the strong and weak emergence of these preferred circulation patterns, respectively.
Predictors of adenoma size and location in primary hyperparathyroidism
Authors: Filser Barbara , Uslar Verena , Weyhe Dirk , Tabriz Navid 
Published: April 2021

Abstract
Purpose
In primary hyperparathyroidism (PHPT), intraoperative localization of the parathyroid adenoma can be challenging, especially in cases of negative preoperative imaging. Since a focused unilateral parathyroidectomy has benefits compared to a conventional bilateral neck exploration, the question arises whether adenoma size prediction can facilitate a targeted approach. We investigated whether single parathyroid adenoma size can be estimated using preoperative parathyroid hormone (PTH), calcium, and phosphate in patients with PHPT. Preoperative imaging accuracy was evaluated.

Methods
The data of 156 patients who underwent curative parathyroidectomy for single adenoma PHPT were analyzed retrospectively. Information obtained included laboratory data, imaging results, intraoperative data, and final pathology. Imaging accuracy was analyzed descriptively. The association between preoperative biochemical markers and adenoma dimensions was investigated using Spearman’s correlation coefficient and multivariable regression modeling.

Results
Cervical ultrasound correctly predicted adenoma laterality in 95.5%, sestamibi scintigraphy in 80.6%, both had lower true-positive rates for quadrant prediction. Patients with negative imaging results showed higher thyroid volumes than those with positive results. Adenoma volume was positively correlated with preoperative PTH (p < 0.001) and calcium (p < 0.001) and negatively correlated with preoperative phosphate (p = 0.001). Using these preoperative biochemical markers and patient age and BMI, adenoma volume can be significantly predicted using the multivariable regression algorithm.

Conclusion
Cervical ultrasound is superior to scintigraphy for predicting adenoma location and should be the first-choice imaging method, but both methods may be limited by increased thyroid volume. Large adenomas are more likely with higher PTH, higher calcium, and lower phosphate levels. In cases of undetermined adenoma location, an estimation of adenoma volume via our algorithm could corroborate sonographic volume measurements of the suspected adenoma.
Effect of Specimen Placement on Model Rock Blasting
Authors: Zhang Zong-Xian , Chi Li Yuan , Zhang Qingbin 
Published: April 2021

AbstractSmall-scale model blasting plays an important role in understanding mechanism of rock fragmentation by blasting and improving blast technology in rock and mining engineering. Because a specimen (or model) often needs to be placed on either a ground or another material in model blasting, an additional interface appears between the specimen and the ground (or material), compared with an engineering blast that does not have such an interface. In this paper, four model blasts with high-speed photography were presented. The results showed that: (1) as the impedance of a rock specimen was smaller than that of the ground material, the specimen was thrown up and a certain amount of kinetic energy was brought with such a bounce. Thus, this placement should be avoided in model blasts. (2) As a rock specimen was placed on three blocks of the same type of rock as the specimen the specimen was not bounced up during blasting. Correspondingly, no kinetic energy was induced by specimen bounce. Therefore, this placement is recommended for model blasting. If very high specific charge must be used in model blasting, the above-recommended method will not work well due to possible breakage of the base material during blasting. In this case, the rock specimen can be placed on a material with smaller impedance than that of the rock specimen so that specimen bounce can be reduced. Accordingly, such a possible specimen bounce should be estimated by stress wave analysis.
Electrochemical deposition of nickel targets from aqueous electrolytes for medical radioisotope production in accelerators: a review
Authors: Mieszkowska M. , Grdeń M. 
Published: April 2021

AbstractThis paper reviews reported methods of the electrochemical deposition of nickel layers which are used as target materials for accelerator production of medical radioisotopes. The review focuses on the electrodeposition carried out from aqueous electrolytes. It describes the main challenges related to the preparation of suitable Ni target layers, such as work with limited amounts of expensive isotopically enriched nickel; electrodeposition of sufficiently thick, smooth and free of cracks layers; and recovery of unreacted Ni isotopes from the irradiated targets and from used electrolytic baths.
Clinical features and risk factors of Raynaud’s phenomenon in primary Sjögren’s syndrome
Authors: Lin Wei , Xin Zhifei , Ning Xiaoran , Li Yang , Ren Xiuying , Su Yashuang , Liu Meilu , Guo Shaoying , Yang Liu , Liu Yixuan , Zhang Fengxiao , Zhang Wen 
Published: April 2021

Abstract
Objective
The aim at the current study was to investigate the clinical characteristics and risk factors of Raynaud’s phenomenon (RP) in patients with primary Sjögren’s syndrome (pSS).

Methods
Retrospective analysis of the medical records of 333 new-onset pSS patients was performed. Demographic, clinical, and serological data were compared between individuals with and without RP. Logistic regression analysis was used to identify risk factors.

Results
RP was present in 11.41% of the pSS patients. pSS-RP patients were younger (49.74±14.56 years vs. 54.46±13.20 years, p=0.04) and exhibited higher disease activity (11 [5.75–15] vs. 7 [4–12], p=0.03) than those without. The prevalence of lung involvement was significantly higher in pSS patients with RP (60.53% vs. 17.29%; p<0.001). A significantly higher proportion of patients with pSS-RP tested positive about antinuclear (ANA), anti-RNP, and anti-centromere antibodies (ACA) compared to those without (p=0.003, <0.001, and 0.01, respectively). Multivariate analysis identified lung involvement (odds ratio [OR]=8.81, 95% confidence interval [CI] 2.02–38.47; p=0.04), anti-RNP positive status (OR=79.41, 95% CI 12.57–501.78; p<0.0001), as well as ACA (OR=13.17, 95% CI 2.60–66.72; p=0.002) as prognostic factors for pSS-RP.

Conclusion
The presence of RP defined a subset of pSS with a unique phenotype, manifesting as increased lung involvement and a higher frequency of anti-RNP antibodies and ACA, as well as greater disease activity. These results suggest that RP has clinical and prognostic value of pSS patients. Further prospective studies with a larger number of subjects are warranted to confirm our findings and assess the prognostic and treatment implications of RP in pSS patients.

Key Points• Raynaud’s phenomenon (RP) was present in 38 (11.41%) of 333 patients with primary Sjögren’s syndrome (pSS), with patients with RP exhibiting a younger age and higher disease activity.• The presence of RP indicates a subset of pSS with a unique phenotype, with manifestations including increased lung involvement and a higher frequency of anti-RNP antibodies and anti-centromere antibodies.• Patients with pSS and RP need close follow-up and long-term observation (including assessment of microangiopathy), with specific attention paid to the possible development of clinical features of systemic sclerosis.
Safe from what? Understanding environmental non-migration in Chilean Patagonia through ontological security and risk perceptions
Authors: Wiegel Hanne , Warner Jeroen , Boas Ingrid , Lamers Machiel 
Published: April 2021

AbstractWhy do communities prefer to stay in place despite potentially dangerous changes in their environment, even when governmental support for outmigration or resettlement is provided? That is the key question this paper seeks to answer. Voluntary immobility is a burgeoning research topic in environmental change-related migration studies, although the role of local sense-making of perceived risks and migration pressures has received only little attention. In order to examine decisions for non-migration, we argue that we need to consider people’s ontological security, or subjective sense of existential safety, which shapes risk perceptions. We apply this to the case of Villa Santa Lucía in Chilean Patagonia, where the local population has rejected relocation policies after the village was severely damaged by a mudslide in December 2017. We show how this rejection is not based on the lack of abilities to move, but on a fundamentally different risk assessment grounded in locally specific social representations of nature and human-nature relations. This alternative understanding of environmental risks allows the local population to uphold their sense of ontological security while remaining in Villa Santa Lucía, and renders relocation to avoid exposure to natural hazards futile or even inconsistent with local identities. We conclude that local sense-making of environmental risks is an important component of a more fine-grained understanding of environmental non-migration decisions.
How to Draw the Line Between Health and Disease? Start with Suffering
Authors: Hofmann Bjørn 
Published: April 2021

AbstractHow can we draw the line between health and disease? This crucial question of demarcation has immense practical implications and has troubled scholars for ages. The question will be addressed in three steps. First, I will present an important contribution by Rogers and Walker who argue forcefully that no line can be drawn between health and disease. However, a closer analysis of their argument reveals that a line-drawing problem for disease-related features does not necessarily imply a line-drawing problem for disease as such. The second step analyzes some alternative approaches to drawing the line between health and disease. While these approaches do not provide full answers to the question, they indicate that the line-drawing question should not be dismissed too hastily. The third step investigates whether the line-drawing problem can find its solution in the concept of suffering. In particular, I investigate whether returning to the origin of medicine, with the primary and ultimate goal of reducing suffering, may provide sources of demarcation between health and disease. In fact, the reason why we pay attention to particular phenomena as characteristics of disease, consider certain processes to be relevant, and specific functions are classified as dys-functions, is that they are related to suffering. Accordingly, using suffering as a criterion of demarcation between health and disease may hinder a wide range of challenges with modern medicine, such as unwarranted expansion of disease, overdiagnosis, overtreatment, and medicalization.
Arithmetic properties of polynomial solutions of the Diophantine equation $$P(x)x^{n+1}+Q(x)(x+1)^{n+1}=1$$
Authors: Dilcher Karl , Ulas Maciej 
Published: April 2021

AbstractFor each integer$$n\ge 1$$n≥1we consider the unique polynomials$$P, Q\in {\mathbb {Q}}[x]$$P,Q∈Q[x]of smallest degreenthat are solutions of the equation$$P(x)x^{n+1}+Q(x)(x+1)^{n+1}=1$$P(x)xn+1+Q(x)(x+1)n+1=1. We derive numerous properties of these polynomials and their derivatives, including explicit expansions, differential equations, recurrence relations, generating functions, resultants, discriminants, and irreducibility results. We also consider some related polynomials and their properties.
Investigation of the uptake of molybdenum by plants from Argentinean groundwater
Authors: Lawson-Wood Kathryn , Jaafar Maisarah , Felipe-Sotelo Mónica , Ward Neil I. 
Published: April 2021

AbstractSome regions of Argentina are affected by high concentrations of molybdenum, arsenic and vanadium from natural sources in their groundwater. In particular, Mo levels in groundwater from Eduardo Castex (La Pampa, Argentina) typically exceed the guidelines for drinking water formerly established by WHO at 70 μg/L. Therefore, this study investigated the uptake of Mo in plants, using cress (Lepidium sativum L.) as a model using hydroponic experiments with synthetic solutions and groundwater from La Pampa. Cress grown from control experiments (150 μg/L Mo, pH 7) presented an average Mo concentration of 35.2 mg/kg (dry weight, d.w.), higher than the typical total plant range (0.7–2.5 mg/kg d.w.) in the literature. Using pooled groundwater samples (65.0–92.5 μg/L Mo) from wells of La Pampa (Argentina) as growth solutions resulted in significantly lower cress Mo levels (1.89–4.59 mg/kg d.w.) than were obtained for synthetic solutions of equivalent Mo concentration. This may be due to the high levels in these groundwater samples of As, V, Fe and Mn which are known to be associated with volcanic deposits. This research addressed the hitherto scarcity of data about the effect of various physicochemical parameters on the uptake of Mo in plants.
Dynamically complete markets under Brownian motion
Authors: Diasakos Theodoros M. 
Published: April 2021

AbstractThis paper investigates how continuous-time trading renders complete a financial market in which the underlying risk process is a Brownian motion. A sufficient condition, that the instantaneous dispersion matrix of the relative dividends is non-degenerate, has been established in the literature for single-commodity, pure-exchange economies with many heterogenous agents where the securities’ dividends as well as the agents’ utilities and endowments include flows during the trading horizon which are analytic functions. In sharp contrast, the present analysis is based upon a different mathematical argument that assumes neither analyticity nor a particular underlying economic environment. The novelty of our approach lies in deriving closed-form expressions for the dispersion coefficients of the securities’ prices. To this end, we assume only that the pricing kernels and dividends satisfy standard growth and smoothness restrictions (mild enough to allow even for options). In this sense, our sufficiency conditions apply irrespectively of preferences, endowments or other structural elements (for instance, whether or not the budget constraints include only pure exchange).
Continuous size fractionation of magnetic nanoparticles by using simulated moving bed chromatography
Authors: Arlt Carsten-Rene , Brekel Dominik , Neumann Stefan , Rafaja David , Franzreb Matthias 
Published: April 2021

AbstractThe size fractionation of magnetic nanoparticles is a technical problem, which until today can only be solved with great effort. Nevertheless, there is an important demand for nanoparticles with sharp size distributions, for example for medical technology or sensor technology. Using magnetic chromatography, we show a promising method for fractionation of magnetic nanoparticles with respect to their size and/or magnetic properties. This was achieved by passing magnetic nanoparticles through a packed bed of fine steel spheres with which they interact magnetically because single domain ferro-/ferrimagnetic nanoparticles show a spontaneous magnetization. Since the strength of this interaction is related to particle size, the principle is suitable for size fractionation. This concept was transferred into a continuous process in this work using a so-called simulated moving bed chromatography. Applying a suspension of magnetic nanoparticles within a size range from 20 to 120 nm, the process showed a separation sharpness of up to 0.52 with recovery rates of 100%. The continuous feed stream of magnetic nanoparticles could be fractionated with a space-time-yield of up to 5 mg/(L∙min). Due to the easy scalability of continuous chromatography, the process is a promising approach for the efficient fractionation of industrially relevant amounts of magnetic nanoparticles.
Load Forecasting Based on LSTM Neural Network and Applicable to Loads of “Replacement of Coal with Electricity”
Authors: Chen Zexi , Zhang Delong , Jiang Haoran , Wang Longze , Chen Yongcong , Xiao Yang , Liu Jinxin , Zhang Yan , Li Meicheng 
Published: April 2021

AbstractWith the complete implementation of the “Replacement of Coal with Electricity” policy, electric loads borne by urban power systems have achieved explosive growth. The traditional load forecasting method based on “similar days” only applies to the power systems with stable load levels and fails to show adequate accuracy. Therefore, a novel load forecasting approach based on long short-term memory (LSTM) was proposed in this paper. The structure of LSTM and the procedure are introduced firstly. The following factors have been fully considered in this model: time-series characteristics of electric loads; weather, temperature, and wind force. In addition, an experimental verification was performed for “Replacement of Coal with Electricity” data. The accuracy of load forecasting was elevated from 83.2 to 95%. The results indicate that the model promptly and accurately reveals the load capacity of grid power systems in the real application, which has proved instrumental to early warning and emergency management of power system faults.
Integrated Commonsense Reasoning and Deep Learning for Transparent Decision Making in Robotics
Authors: Mota Tiago , Sridharan Mohan , Leonardis Aleš 
Published: April 2021

AbstractA robot’s ability to provide explanatory descriptions of its decisions and beliefs promotes effective collaboration with humans. Providing the desired transparency in decision making is challenging in integrated robot systems that include knowledge-based reasoning methods and data-driven learning methods. As a step towards addressing this challenge, our architecture combines the complementary strengths of non-monotonic logical reasoning with incomplete commonsense domain knowledge, deep learning, and inductive learning. During reasoning and learning, the architecture enables a robot to provide on-demand explanations of its decisions, the evolution of associated beliefs, and the outcomes of hypothetical actions, in the form of relational descriptions of relevant domain objects, attributes, and actions. The architecture’s capabilities are illustrated and evaluated in the context of scene understanding tasks and planning tasks performed using simulated images and images from a physical robot manipulating tabletop objects. Experimental results indicate the ability to reliably acquire and merge new information about the domain in the form of constraints, preconditions, and effects of actions, and to provide accurate explanations in the presence of noisy sensing and actuation.
Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem
Authors: Pałasz Artur , Żarczyński Piotr , Bogus Katarzyna , Mordecka-Chamera Kinga , Della Vecchia Alessandra , Skałbania Jakub , Worthington John J. , Krzystanek Marek , Żarczyńska Małgorzata 
Published: April 2021

Abstract
Background
Phoenixin, spexin and nesfatin-1 belong to a family of newly discovered multifunctional neuropeptides that play regulatory roles in several brain structures and modulate the activity of important neural networks. However, little is known about their expression and action at the level of brainstem. The present work was, therefore, focused on gene expression of the aforementioned peptides in the brainstem of rats chronically treated with olanzapine, a second generation antipsychotic drug.

Methods
Studies were carried out on adult, male Sprague–Dawley rats that were divided into 2 groups: control and experimental animals treated with olanzapine (28-day-long intraperitoneal injection, at dose 5 mg/kg daily). All individuals were killed under anesthesia and the brainstem excised. Total mRNA was isolated from homogenized samples of both structures and the RT-PCR method was used for estimation of related SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expression.

Results
Long-term treatment with olanzapine is reflected in qualitatively different changes in expression of examined neuropeptides mRNA in the rat brainstem. Olanzapine significantly decreased NPQ/spexin mRNA expression, but increased SMIM20/phoenixin mRNA level in the rat brainstem; while NUCB2/nesfatin-1 mRNA expression remained unchanged.

Conclusions
Olanzapine can affect novel peptidergic signaling in the rat brainstem. This may cautiously suggest the presence of an alternative mode of its action.