bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Conservative Right to Privacy: Legal, Ideological, and Coalitional Transformations in US Social Conservatism
Authors: Wuest Joanna 
Published: April 2021

AbstractThe right to privacy has long been regarded as a liberal progressive principle, one that guarantees gender-based equality and liberty in the domain of reproductive rights. Since the US Supreme Court’s renowned articulation of privacy inRoe v. Wade, privacy’s opponents have condemned the right as an illegitimate judicial invention with no basis in the Constitution. This article addresses the puzzle of why a coalition of Christian conservative legal organizations, conservative foundations, Trump administration officials, Republican party lawmakers, and trans-exclusionary radical feminists has assembled to redefine the right to privacy in service of anti-transgender politics. While much attention has been paid to the proliferation of religious liberty-based challenges to the rights of sexual and gender minorities, these accounts miss how central the fight to reassociate privacy has become in conflicts waged in state and federal courts, city and state legislatures, and ballot referendum campaigns. Although this coalition eschews any mention ofRoeor reproductive rights, it does adopt a substantive due process-based interpretation of privacy’s mandate despite the typical conservative disdain for that doctrine. Additionally, the coalition frames its project as one that balances competing rights claims by defending (cis) women’s rights against allegedly lopsided trans-inclusive reforms.
Did shell-crushing predators drive the evolution of ammonoid septal shape?
Authors: Johnson Erynn H. , DiMarco Briana M. , Peterman David J. , Carter Aja M. , Allmon Warren D. 
Published: April 2021

AbstractFor centuries, paleontologists have sought functional explanations for the uniquely complex internal walls (septa) of ammonoids, extinct shelled cephalopods. Ammonoid septa developed increasingly complex fractal margins, unlike any modern shell morphologies, throughout more than 300 million years of evolution. Some have suggested these morphologies provided increased resistance to shell-crushing predators. We perform the first physical compression experiments on model ammonoid septa using controlled, theoretical morphologies generated by computer-aided design and 3D printing. These biomechanical experiments reveal that increasing complexity of septal margins does not increase compression resistance. Our results raise the question of whether the evolution of septal shape may be tied closely to the placement of the siphuncle foramen (anatomic septal hole). Our tests demonstrate weakness in the centers of uniformly thick septa, supporting work suggesting reinforcement by shell thickening at the center of septa. These experiments highlight the importance of 3D reconstruction using idealized theoretical morphologies that permit the testing of long-held hypotheses of functional evolutionary drivers by recreating extinct morphologies once rendered physically untestable by the fossil record.
Fossil bivalves and the sclerochronological reawakening
Authors: Moss David K. , Ivany Linda C. , Jones Douglas S. 
Published: April 2021

AbstractThe field of sclerochronology has long been known to paleobiologists. Yet, despite the central role of growth rate, age, and body size in questions related to macroevolution and evolutionary ecology, these types of studies and the data they produce have received only episodic attention from paleobiologists since the field's inception in the 1960s. It is time to reconsider their potential. Not only can sclerochronological data help to address long-standing questions in paleobiology, but they can also bring to light new questions that would otherwise have been impossible to address. For example, growth rate and life-span data, the very data afforded by chronological growth increments, are essential to answer questions related not only to heterochrony and hence evolutionary mechanisms, but also to body size and organism energetics across the Phanerozoic. While numerous fossil organisms have accretionary skeletons, bivalves offer perhaps one of the most tangible and intriguing pathways forward, because they exhibit clear, typically annual, growth increments and they include some of the longest-lived, non-colonial animals on the planet. In addition to their longevity, modern bivalves also show a latitudinal gradient of increasing life span and decreasing growth rate with latitude that might be related to the latitudinal diversity gradient. Is this a recently developed phenomenon or has it characterized much of the group's history? When and how did extreme longevity evolve in the Bivalvia? What insights can the growth increments of fossil bivalves provide about hypotheses for energetics through time? In spite of the relative ease with which the tools of sclerochronology can be applied to these questions, paleobiologists have been slow to adopt sclerochronological approaches. Here, we lay out an argument and the methods for a path forward in paleobiology that uses sclerochronology to answer some of our most pressing questions.
THE HISTORIA AVGVSTA BEFORE MS PAL. LAT. 899: LOST MANUSCRIPTS AND SCRIBAL MEDIATION
Authors: Shedd Martin 
Published: April 2021

AbstractThis article re-evaluates the role of the manuscript tradition of the Historia Augusta in debates over the original contents and authorship of the text. Evidence for physical disruptions to the text before our oldest surviving manuscripts points to an earlier manuscript distributed across multiple codices. A multi-volume archetype eliminates critical arguments against the author's claims about lives missing before the Life of Hadrian as well as in the lacuna for the years a.d. 244–260. Other multi-volume codices of the eighth and ninth centuries show that loss of an initial volume would have disrupted the textual tradition for the index, titles and authorial attributions. Comparison of our most complete early witness, Pal. lat. 899, to the independent branches of the textual tradition shows discrepancies between these paratextual elements as expected in a disrupted tradition. Ultimately, this article concludes that the current debates on authorship and the original scope of the Historia Augusta rest on paratextual elements from a single branch of the manuscript tradition, raising doubts about the centrality of these controversies to understanding the work.
RURAL WORKERS AND THE ROLE OF THE RURAL IN EIGHTEENTH-CENTURY ENGLISH FOOD RIOTING
Authors: GRIFFIN CARL J. 
Published: April 2021

AbstractNo form of English popular protest has been subject to such close scholarly analysis as the eighteenth-century food riot, a response not just to the understanding that food riots comprised two out of every three crowd actions but also to the influence of E. P. Thompson's seminal paper ‘The moral economy of the English crowd’. If the food riot is now understood as an event of considerable complexity, one assertion remains unchallenged: that riots remained a tradition of the towns, with agrarian society all but unaffected by food rioting. This article offers a new interpretation in which the rural is not just the backdrop to food protests but instead a locus and focus of collective actions over the marketing of provisions, with agricultural workers taking centre stage. It is shown that agricultural workers often took the lead in market town riots as well as well as in instigating riots in the countryside. Further, such episodes of collective protest were neither rare nor unusual but instead formed an integral part of the food rioting repertoire. It is also shown that rural industrial workers – notoriously active in market town riots – were often joined or even led by agricultural workers in their protests.
Grand challenges for the 21st century: what crop models can and can't (yet) do
Authors: Silva João Vasco , Giller Ken E. 
Published: April 2021

AbstractCrop production is at the core of a ‘perfect storm’ encompassing the grand challenges of achieving food and nutrition security for all, in the face of climate change, while avoiding further conversion of natural habitats for agriculture and loss of biodiversity. Here, we explore current trends in crop modelling related to these grand challenges by reflecting on research presented at the Second International Crop Modelling Symposium (iCropM2020). A keyword search in the book of abstracts of the symposium revealed a strong focus on ‘climate change’, ‘adaptation’ and ‘impact assessment’ and much less on ‘food security’ or ‘policy’. Most research focused on field-level investigations and far fewer on farm(ing) systems levels – the levels at which management decisions are made by farmers. Experimentation is key to development and testing of crop models, yet the term ‘simulation’ outweighed by far the terms ‘experiments’ and ‘trials’, and few contributions dealt with model improvement. Cereals are intensively researched, whereas roots, tubers and tropical perennials are under-researched. Little attention is paid to nutrient limitations apart from nitrogen or to pests and diseases. The aforementioned aspects represent opportunities for future research where crop models can help in devising hypotheses and driving new experimentation. We must also ensure that crop models are fit for their intended purposes, especially if they are to provide advice to policymakers. The latter, together with cross-scale and interdisciplinary efforts with direct engagement of stakeholders are needed to address the grand challenges faced by food and agricultural systems in the next century.
When simple self-reference is too simple: Managing the categorical relevance of speaker self-presentation
Authors: Whitehead Kevin A. , Lerner Gene H. 
Published: April 2021

AbstractMembership categories such as ‘doctor’, ‘customer’, and ‘girl’ can form a set of alternative ways of referring to the same person. Moreover, speakers can select from this array of correct alternatives that term best fitted to what is getting done in their talk. In contrast, self-references alone ordinarily do not convey category membership, unless the speaker specifically employs some sort of category-conveying formulation. This report investigates how speakers manage the categorical relevance of these simplest self-references (e.g. ‘I’, ‘me’, ‘my’) as a practical means of self-presentation. We first describe how speakers forestall recipient attribution of membership categories. We then consider cases where simple self-references are subjected to subsequent elaboration—via self-categorization—in the face of possible recipient misreading of the speaker's category membership. Thereafter, we introduce the practice of contrastive entanglement, and describe how speakers employ it to fashion tacitly categorized self-references that serve the formation of action. (Person reference, conversation analysis, membership categorization devices, race, gender)*
The End of the Ninth Legion, War in Britain and the Building of Hadrian's Wall
Authors: Hodgson Nick 
Published: April 2021

ABSTRACTIt is often stated that the Ninth Legion was transferred from Britain and continued to exist until the 130s or beyond. The evidence is reviewed, and it is concluded that: (1) no more than a detachment of the legion went abroad, and that only for the period c. 105 to c. 120; (2) there is no prosopographical or other evidence which proves that the legion existed after the early 120s. Given that war, heavy Roman losses and an interruption in the building of Hadrian's Wall are directly attested in Britain, probably occurring in 122 or shortly after, it is argued that it is most likely that the legion was defeated and disbanded in connection with those events.
What Should We Agree on about the Repugnant Conclusion?
Authors: Zuber Stéphane , Venkatesh Nikhil , Tännsjö Torbjörn , Tarsney Christian , Stefánsson H. Orri , Steele Katie , Spears Dean , Sebo Jeff , Pivato Marcus , Ord Toby , Ng Yew-Kwang , Masny Michal , MacAskill William , Lawson Nicholas , Kuruc Kevin , Hutchinson Michelle , Gustafsson Johan E. , Greaves Hilary , Forsberg Lisa , Fleurbaey Marc , Coffey Diane , Cato Susumu , Castro Clinton , Campbell Tim , Budolfson Mark , Broome John , Berger Alexander , Beckstead Nick , Asheim Geir B. 
Published: April 2021

The Repugnant Conclusion is an implication of some approaches to population ethics. It states, in Derek Parfit's original formulation,
For any possible population of at least ten billion people, all with a very high quality of life, there must be some much larger imaginable population whose existence, if other things are equal, would be better, even though its members have lives that are barely worth living. (Parfit 1984: 388)
The risk to child nutrition during and after COVID-19 pandemic: what to expect and how to respond
Authors: Ntambara James , Chu Minjie 
Published: April 2021

AbstractObjective:The current study aimed to address the key areas of concern for child nutrition, both during and after the COVID-19 pandemic, and proposes strategic responses to reduce child undernutrition in the short and long term.Design:A descriptive literature review was performed. The search of the literature was conducted through using electronic databases including PubMed, Web of Science, Google Scholar and Cochrane library.Setting:A wide range of published articles focused on child malnutrition were reviewed.Participants:The study was focused on children especially those under 5 years.Results:The current study proposes strategic responses to reduce child undernutrition. These responses include strengthening access to community-based nutrition services that support the early detection and treatment of undernourished children and emergency food distribution, including fortified foods with vitamins and minerals, to vulnerable households, particularly those with children under 5 years. Moreover, counseling and promotion programmes should be reinforced to revitalise community nutrition education in areas such as gestation, exclusive breast-feeding and complementary feeding, and hygienic practices involving handwashing, proper sanitation and other basic behavioural changes.Conclusions:The COVID-19 pandemic has affected many countries especially those in the regions of South Asia and sub-Saharan Africa in which there has been an ongoing burden of child undernutrition. However, malnutrition is preventable and can be eliminated through a multisectoral strategic approach. The effective execution of a multisectoral approach towards preventing childhood malnutrition will require not only a financial investment but also the collective efforts from different ministries of the governments, UN-affiliated agencies and non-governmental organisations.
INVARIANT SETS AND NORMAL SUBGROUPOIDS OF UNIVERSAL ÉTALE GROUPOIDS INDUCED BY CONGRUENCES OF INVERSE SEMIGROUPS
Authors: KOMURA FUYUTA 
Published: April 2021

AbstractFor a given inverse semigroup, one can associate an étale groupoid which is called the universal groupoid. Our motivation is studying the relation between inverse semigroups and associated étale groupoids. In this paper, we focus on congruences of inverse semigroups, which is a fundamental concept for considering quotients of inverse semigroups. We prove that a congruence of an inverse semigroup induces a closed invariant set and a normal subgroupoid of the universal groupoid. Then we show that the universal groupoid associated to a quotient inverse semigroup is described by the restriction and quotient of the original universal groupoid. Finally we compute invariant sets and normal subgroupoids induced by special congruences including abelianization.
Study on the ULF Magnetic Field Generated by Earth Currents Relating to Large EQs
Authors: Zhou H. , Yan F. , Wang J. , Luo Q. , Jin T. 
Published: April 2021

AbstractULF magnetic anomalies (f < 1 Hz) have been observed prior to multiple large earthquakes (EQs) during the last three decades. A polarization analysis method was produced and applied in many EQ cases in order to discriminate the weak ULF crustal signals from other signals. Although many publications considered the parameter of polarization ratio (amplitude or power ratio of vertical magnetic field component to horizontal components), a key parameter in the polarization analysis method, useful to detect the possible magnetic signals associated with EQs, there were also many doubts on its reliability. The aim of this work is to evaluate the possibilities of the polarization ratio increases prior to large EQs based on the prevail assumption of Earth currents as the source of ULF emissions during the early stage of EQ preparation independent of the mechanism involved in producing the currents, and the parallel 3‐D finite‐difference time‐domain technique is applied to calculate the electromagnetic responses in the whole inhomogeneous Earth‐ionosphere waveguide. The contributions of the lightning discharges on ULF power are also evaluated based on the gridded flash counts included in the Lightning Imaging Sensor climatology data. The results reveal that the surface vertical magnetic field and polarization ratio are possible to increase locally around the epicenters as long as the intensity of the surface seismic magnetic fields are large enough compared with those produced by other sources. Unfortunately, the actual increases are usually difficult to be distinguished obviously mostly due to the weak seismic increases.
Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice
Authors: Nakamura Takashi , Nampei Mai , Murase Takayo , Satoh Etsuko , Akari Seigo , Katoh Noriaki , Mizukami Hiroki 
Published: April 2021

AbstractPlasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight. Male db/db mice were fed standard diets with or without topiroxostat for 4 weeks. Body weight and food intake were constantly monitored, along with monitoring plasma biochemical markers, including insulin and XOR activity. Additionally, hepatic hypoxanthine and XOR activity were also documented. Single regression analysis was performed to determine the mechanism. Topiroxostat treatment suppressed weight gain relative to the vehicle without any impact on food intake. However, the weight of fat pads and hepatic and muscle triglyceride content did not change. Topiroxostat decreased the plasma uric acid and increased hepatic hypoxanthine in response to the inhibition of XOR activity. Plasma ketone body and free fatty acid were also increased. Moreover, fat weight was weakly associated with plasma XOR activity in the diabetic state and was negatively associated with ketone body by topiroxostat. These results suggested that topiroxostat amplified the burning of lipids and the salvage pathway, resulting in predisposing the body toward catabolism. The inhibition of plasma XOR activity may contribute to weight loss.
The glycolytic process in endothelial cells and its implications
Authors: Leung Susan, Wai Sum , Shi Yi 
Published: April 2021

AbstractEndothelial cells play an obligatory role in regulating local vascular tone and maintaining homeostasis in vascular biology. Cell metabolism, converting food to energy in organisms, is the primary self-sustaining mechanism for cell proliferation and reproduction, structure maintenance, and fight-or-flight responses to stimuli. Four major metabolic processes take place in the energy-producing process, including glycolysis, oxidative phosphorylation, glutamine metabolism, and fatty acid oxidation. Among them, glycolysis is the primary energy-producing mechanism in endothelial cells. The present review focused on glycolysis in endothelial cells under both physiological and pathological conditions. Since the switches among metabolic processes precede the functional changes and disease developments, some prophylactic and/or therapeutic strategies concerning the role of glycolysis in cardiovascular disease are discussed.
NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15
Authors: Guo Feng , Zhou Yingke , Guo Hui , Ren Dianyun , Jin Xin , Wu Heshui 
Published: April 2021

AbstractNR5A2 is a transcription factor regulating the expression of various oncogenes. However, the role of NR5A2 and the specific regulatory mechanism of NR5A2 in pancreatic ductal adenocarcinoma (PDAC) are not thoroughly studied. In our study, Western blotting, real-time PCR, and immunohistochemistry were conducted to assess the expression levels of different molecules. Wound-healing, MTS, colony formation, and transwell assays were employed to evaluate the malignant potential of pancreatic cancer cells. We demonstrated that NR5A2 acted as a negative prognostic biomarker in PDAC. NR5A2 silencing inhibited the proliferation and migration abilities of pancreatic cancer cells in vitro and in vivo. While NR5A2 overexpression markedly promoted both events in vitro. We further identified that NR5A2 was transcriptionally upregulated by BRD4 in pancreatic cancer cells and this was confirmed by Chromatin immunoprecipitation (ChIP) and ChIP-qPCR. Besides, transcriptome RNA sequencing (RNA-Seq) was performed to explore the cancer-promoting effects of NR5A2, we found that GDF15 is a component of multiple down-regulated tumor-promoting gene sets after NR5A2 was silenced. Next, we showed that NR5A2 enhanced the malignancy of pancreatic cancer cells by inducing the transcription of GDF15. Collectively, our findings suggest that NR5A2 expression is induced by BRD4. In turn, NR5A2 activates the transcription of GDF15, promoting pancreatic cancer progression. Therefore, NR5A2 and GDF15 could be promising therapeutic targets in pancreatic cancer.
Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism
Authors: Park Bo-yong , Hong Seok-Jun , Valk Sofie L. , Paquola Casey , Benkarim Oualid , Bethlehem Richard A. I. , Di Martino Adriana , Milham Michael P. , Gozzi Alessandro , Yeo B. T. Thomas , Smallwood Jonathan , Bernhardt Boris C. 
Published: April 2021

AbstractThe pathophysiology of autism has been suggested to involve a combination of both macroscale connectome miswiring and microcircuit anomalies. Here, we combine connectome-wide manifold learning with biophysical simulation models to understand associations between global network perturbations and microcircuit dysfunctions in autism. We studied neuroimaging and phenotypic data in 47 individuals with autism and 37 typically developing controls obtained from the Autism Brain Imaging Data Exchange initiative. Our analysis establishes significant differences in structural connectome organization in individuals with autism relative to controls, with strong between-group effects in low-level somatosensory regions and moderate effects in high-level association cortices. Computational models reveal that the degree of macroscale anomalies is related to atypical increases of recurrent excitation/inhibition, as well as subcortical inputs into cortical microcircuits, especially in sensory and motor areas. Transcriptomic association analysis based on postmortem datasets identifies genes expressed in cortical and thalamic areas from childhood to young adulthood. Finally, supervised machine learning finds that the macroscale perturbations are associated with symptom severity scores on the Autism Diagnostic Observation Schedule. Together, our analyses suggest that atypical subcortico-cortical interactions are associated with both microcircuit and macroscale connectome differences in autism.