bluuebunny/crossref_metadata_2025_split huggingface dataset:
Less is More: Biomimetic Hybrid Membrane Nanocarriers for Highly Efficient Tumor Targeted Drug Delivery
Authors: Chen Siwen , Lan Haibo , Liu Minyi , He Chenxi , Li Qiuyu , Zheng Shuting , Zheng Yinfei , Wu Zede , Liu Tiancai , Zhao Bingxia 
Published: December 2024

AbstractBiomimetic camouflaged nanocarriers coated with cancer cell membranes (CCMs) have attracted considerable research attention for drug delivery application. CCM‐camouflaged nanocarriers have inherent tumor‐homologous targeting ability. However, they enter cancer cells via endocytosis, which is not efficient for drug delivery. Switching the internalization mechanism to membrane fusion may enhance their delivery efficiency. In this study, an innovative biomimetic‐targeting nanocarrier is designed by hybridizing CCMs with pH‐sensitive liposomes (1,2‐dioleoyl‐sn‐glycero‐3‐phosphoethanolamine liposomes, DOPE‐Lipo), named as CCMpHD. The presence of CCMs makes the nanocarriers capable of homologous targeting, and the DOPE‐Lipo hybrid allows the nanocarriers to achieve efficient internalization via membrane fusion. Notably, the cellular uptake of CCMpHD is significantly higher than that of the CCMs. The most efficient delivery is achieved with 1/10 CCMs, which requires remarkably less cell membranes. Doxorubicin (DOX) is used as a model drug to characterize the homologous targeting drug delivery properties of the hybrid nanocarriers. Both in vitro and in vivo experiments demonstrated that the nanocarriers exhibited satisfactory biosafety and enhanced tumor‐targeted delivery. With enhanced delivery efficiency whilst requiring fewer CCMs, these hybrid membrane nanocarriers provides a new strategy for CCM‐based drug delivery in cancer treatment.
Analytical Photoresponses of Schottky‐Contact MoS2 Phototransistors
Authors: Wei Jianyong , Liu Yumeng , Wang Yizhuo , Li Kai , Lian Zhentao , Xie Maosong , Yang Xinhan , Khaleghi Seyed Saleh Mousavi , Dai Fuxing , Hu Weida , Gao Xuejiao , Yang Rui , Dan Yaping 
Published: December 2024

AbstractHigh‐gain photodetectors based on 2D semiconductors have been extensively investigated in the past decades. However, the underlying mechanism remains in dispute without a proper analytical theory. On one side, the classical photogain theory is not applicable, as it was derived on two misplaced assumptions. On the other side, unexpected potential barriers usually present in 2D semi‐conductors but their effect on the ultrahigh gain has been largely ignored. In this work, we first established a universal I‐V equation for Schottky‐contact MoS2 phototransistors, modeled with two anti‐symmetric Schottky diodes and a channel resistor in series. It has been proved to be valid under varying conditions of gate voltage, temperature, light illumination and bias voltage. Moreover, we established analytical equations for photocurrent and gain, which clearly shows that ultrahigh gain is created by light‐induced modulation of potential barrier in exponential form. Finally, the theory was validated on 40 samples by verifying the I–V characteristics and minority carrier lifetime. Our results not only shed light on the working mechanism of 2D phototransistors, but also present important advance for device modeling and design in 2D integrated circuits.
Ion Intercalation‐Enabled Reconfigurable Photodetector with Low Programming Voltage and Broadband Response Based on Van Der Waals Tin Disulfide
Authors: Leng Kangmin , Wan Yu , Wang Xin , Wang Li , Fu Yao , Wang Qisheng 
Published: December 2024

AbstractArtificial neural networks with integrated sensing and computing capabilities, leveraging reconfigurable optoelectronics, can effectively emulate biological neural networks, thereby enabling rapid and efficient information processing. However, realizing reconfigurable photoresponsivity is often blocked by the requirement for high programming voltages and the limits of the detection spectrum range. This greatly restricts the progress of energy‐efficient and precise neuromorphic vision sensing. Herein, a reconfigurable photodetector with low programming voltage and broadband response is presented via in situ intercalation of Cu+ ions into the van der Waals (vdW) gaps of thermoelectric 2D material SnS2. Interestingly, the vdW gaps provide an ionic transport channel with lower energy barriers compared to oxide‐based memristors, resulting in a low programming voltage (0.5 V). Furthermore, reversible conversion of photo‐detection is achieved from photovoltaic to photo‐thermoelectric (PTE) mode via voltage‐controlled ion distribution, which modulates the phonon scattering rate in the neighboring SnS2 layer. As a result, the response spectrum switches from visible (532 nm) to long‐wave infrared (10 µm) with an on/off ratio as high as 104. Thus, dual‐mode conversion and broadband detection functionality in reconfigurable imaging are realized, suggesting a potential pathway for the development of highly energy‐efficient reconfigurable optoelectronics with a spectrum far beyond human vision.
Surface‐Engineered 2D Bimetallic FeNi‐MOFs Derived from Layered Double Hydroxides for Photocatalytic Membranes with Enhanced Dye Fixation in Wastewater Treatment
Authors: Karthikeyan Gayathri , Mohan Sakar , Austeria P. Muthu , Balakrishna R. Geetha 
Published: December 2024

AbstractFeNi‐based layered double hydroxides (LDHs) are used as precursors to derive bimetallic FeNi‐metal organic frameworks (D‐FeNi MOFs) with terephthalic acid ligands, offering enhanced properties compared to conventionally prepared FeNi‐MOFs (C‐FeNi MOFs). D‐FeNi MOFs exhibited superior structural, surface, and electrochemical features, confirmed by density functional theory (DFT) studies, which also predicted their catalytic mechanism. Band edge potential calculations through Mott–Schottky analysis revealed their favorable redox potential, enhanced charge transfer, and reduced recombination resistance, explaining their superior photocatalytic efficiency. D‐FeNi MOFs degraded 91% of rhodamine B (RhB) and 89% of Congo red (CR), outperforming C‐FeNi MOFs, which degraded 84% and 77%, respectively. These MOFs are incorporated (3, 5, and 7 wt%) into polysulfone (PSU) membranes to develop photocatalytic membranes. The 7 wt% membranes (FNM7) exhibited high water flux (54.4 L m−2h−1) and dye flux (≈51.1 and 41.6 L m−2h−1) with rejection rates of ≈88% and 90% for RhB and CR, significantly surpassing bare membranes. FNM7 demonstrated superior anti‐fouling and photocatalytic regeneration (12.9% RhB, 9.6% CR degradation under sunlight) across three cycles. DFT studies showed FeNi centers weaken dye molecule bonds, aiding degradation, while carboxyl groups in MOFs formed robust hydrogen bonds with PSU, ensuring no particle leaching. This highlights D‐FeNi MOF‐membranes as an efficient system for wastewater treatment.
Consecutive Complex Aggregation Pathway in Covalent Helical Polymer‐Metal Complexes: Nanospheres with Controlled P/M Macroscopic Chirality
Authors: Tarrío Juan José , Hermida Borja , Rodríguez Rafael , Crassous Jeanne , Quiñoá Emilio , Freire Félix 
Published: December 2024

AbstractKinetically trapped and thermodynamic nanospheres with opposite macroscopic P/M chirality and opposite circularly polarized luminescence (CPL) can be obtained from a single helical polymer‐metal complex under the same environmental conditions. To prepare these nanospheres, a chiral poly(diphenylacetylene) (PDPA) [poly‐(L)‐1] with a large energy barrier between the P and M helical senses is chosen as source of chirality, while Ba2+ metal ions are selected as crosslinking agents. As a result, the poly‐(L)‐1/Ba2+ complex can generate both kinetically trapped (Agg1, M nanospheres) and thermodynamic (Agg2, P nanospheres) aggregates, which can be dispersed in the same solvent. Due to the high energy barrier of the helix inversion process for poly‐(L)‐1, the complete evolution from the kinetically trapped aggregate (Agg1, M nanospheres) to the thermodynamic one (Agg2, P nanospheres) takes more than 75 days at room temperature, which can be accelerated at higher temperatures. These nanospheres are stable and remain dispersed in solution for up to 8 months without further aggregation.
Heart‐on‐a‐Miniscope: A Miniaturized Solution for Electrophysiological Drug Screening in Cardiac Organoids
Authors: Tirgar Pouria , Vikstrom Abigail , Sepúlveda José Miguel Romero , Srivastava Luv Kishore , Amini Ali , Tabata Tomoka , Higo Shuichiro , Bub Gil , Ehrlicher Allen 
Published: December 2024

AbstractCardiovascular toxicity remains a primary concern in drug development, accounting for a significant portion of post‐market drug withdrawals due to adverse reactions such as arrhythmias. Traditional preclinical models, predominantly based on animal cells, often fail to replicate human cardiac physiology accurately, complicating the prediction of drug‐induced effects. Although human‐induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) provide a more genetically relevant system, their use in 2D, static cultures does not sufficiently mimic the dynamic, 3D environment of the human heart. 3D cardiac organoids made from human iPSC‐CMs can potentially bridge this gap. However, most traditional electrophysiology assays, developed for single cells or 2D monolayers, are not readily adaptable to 3D organoids. This study uses optical calcium analysis of human organoids combined with miniaturized fluorescence microscopy (miniscope) and heart‐on‐a‐chip technology. This simple, inexpensive, and efficient platform provides robust on‐chip calcium imaging of human cardiac organoids. The versatility of the system is demonstrated through cardiotoxicity assay of drugs known to impact cardiac electrophysiology, including dofetilide, quinidine, and thapsigargin. The platform promises to advance drug testing by providing a more reliable and physiologically relevant assessment of cardiovascular toxicity, potentially reducing drug‐related adverse effects in clinical settings.
Balancing Competitive Adsorption on Co3O4@P, N‐Doped Porous Carbon to Enhance the Electrocatalytic Upgrading of Biomass Derivatives
Authors: Li Ming , Sun Haixin , Wang Chen , Liu Yongzhuang , Xia Qinqin , Meng Juan , Yu Haipeng , Dou Shuo 
Published: December 2024

AbstractThe electrocatalytic oxidation of 5‐hydroxymethylfurfural (HMF) represents an environmentally friendly approach to generate high‐value‐added chemicals from biomass. The successful electrochemical transformation of HMF during the oxidation reaction (HMFOR) necessitates an ideal adsorption interaction between HMF and OH− on the electrode surface. Yet, catalysts with a singular active site offer limited flexibility in managing the competitive adsorption of HMF and OH−. To this end, different active sites are customized in this work to construct a P and N co‐doped porous carbon that wrapped Co3O4 (Co3O4@PNC). Co‐doping with these two heteroatoms generates C3P = O and pyrrolic N as adsorption sites to better balance the adsorption of HMF and OH−, respectively, rather than promoting competition between the HMF and OH− on a single active site. With this design strategy, Co3O4@PNC demonstrates significant HMFOR activity, the conversion rate of HMF surpassed 99% with a 2,5‐furandicarboxylic acid (FDCA) yield exceeding 95% after 2 h of electrolysis. Furthermore, it shows universal applicability in the electrooxidation of other alcohol/aldehyde substrates, yielding efficiencies of 90–99%. This work not only provides guidance for advanced electrocatalysts design toward alcohol/aldehyde oxidation but also offers insights into the utilization of biomass‐derived platform chemicals.
Substitutional Platinum‐Phosphorus Solid Solution by Phosphidation of Worm‐Like Pt Nanoparticles Using Tri‐n‐octylphosphine
Authors: Liu Hui , Yang Niuwa , Ma Mengyuan , Chen Dong , Tian Shaonan , Xu Lin , Huang Wenlai , Yang Jun 
Published: December 2024

AbstractHerein, the investigations into the phosphidation of platinum (Pt) nanoparticles are reported using tri‐n‐octylphosphine (TOP) at elevated temperature in an organic solvent, and identify a unique phenomenon not addressed before: The phosphorus (P) atoms can replace partial Pt atoms from their lattice points to form a substitutional Pt‐P solid solution. The rationality is authenticated for forming substitutional Pt–P solid solution via P doping by various characterizations and density functional theory (DFT) calculations, both of which suggests that the maximum P content in the Pt–P solid solution is approximately ≈10% for maintaining the stability of the face‐centered cubic crystal structure.
Phase Transition Driven Zn‐Ion Battery With Laser‐Processed V2C/V2O5 Electrodes for Wearable Temperature Monitoring
Authors: Deshmukh Sujit , Vaghasiya Jayraj V. , Michalička Jan , Langer Rostislav , Otyepka Michal , Pumera Martin 
Published: December 2024

AbstractFlexible power supply devices present significant potential for wearable bioelectronics within the Internet of Things. Aqueous zinc‐ion batteries have emerged as a viable and safe alternative for power supply in flexible electronics. Nevertheless, typical battery behaviors are generally detrimental with unfavorable phase transition of electrodes, which invariably lead to rapid performance degradation. Here, extraordinary capacity enhancement of 150% is presented, sustained over 60 000 cycles, attained using vanadium carbide MXene (V2C)/vanadium pentoxide (V2O5) heterostructure as cathode. The unique cathode material is created through the rational engineering of MAX (V2AlC), employing a single‐step laser writing process. The ultrastable Zn ion battery stands in stark contrast to all previously reported counterparts, which typically exhibit capacity degradation within a few hundred/thousand cycles. The primary mechanisms driving this enhancement include the delamination of V2C MXene and an unexpected favorable phase transition during cycling. Additionally, a wearable power supply is constructed using a series configuration and is integrated with a commercial temperature sensor for wireless, real‐time body temperature monitoring. This study highlights the critical role of electrode design for advanced wearable bioelectronics.
Gliding Arc Plasma Induced One‐Step Millisecond Synthesis of Highly Crystalline Mesoporous TiO2 Homojunctions for Robust Photocatalytic H2 Production
Authors: Zhang Siyuan , Li Xiaosong , Zhu Aimin , Hou Jungang 
Published: December 2024

AbstractOne of the major challenges in photocatalytic hydrogen production lies in the charge separation and transfer. Herein, a one‐step millisecond synthesis of highly crystalline mesoporous TiO2 homojunction nanostructures through the gliding arc plasma is developed toward efficient photocatalytic hydrogen production. The unique non‐thermal plasma environment uniquely enables the concurrent attainment of high crystallinity, well‐defined mesoporosity, and homojunction formation within millisecond. The synthesized TiO2 predominantly comprises an anatase phase (≈80%), with the remainder being a rutile phase. By varying the gas flow rate, there is a noticeable transition in particle morphology from spherical to non‐spherical, accompanied by a gradual reduction in particle size. The mechanism underlying the one‐step synthesis of mesoporous TiO2 homojunctions through gliding arc plasma has been elucidated using in situ emission spectroscopy and band‐pass filter imaging. The optimized TiO2 homojunctions exhibited exceptional photocatalytic hydrogen production rate, 4.32 mmol g−1 h−1 under simulated solar light irradiation, corresponding excellent stability, and reusability. This work not only demonstrates the potential of gliding arc plasma technology for advanced material synthesis but also opens new avenues for the scalable production of high‐performance photocatalysts for sustainable hydrogen production.
Strain‐Modulated Dominant Response Band of Self‐Powered Photodetector Based on WSe2 Lateral PN Homojunction
Authors: Pei Yongfeng , Kang Yufan , Zhou Xinyi , Ma Mingjun , Yang Mingyu , He Dong , Li Wenqing , Xiao Xiangheng 
Published: December 2024

AbstractFlexible devices based on 2D materials have shown promising application capacity in next‐generation optoelectronics. The lack of inversion centrosymmetry renders odd‐layered 2D transition metal dichalcogenides (TMDs) to be piezoelectric, which means the properties modulation of them gets rid of the limit to the gate voltage and they can be directly gated by external strain. Here, a self‐powered photodetector based on WSe2 lateral PN homojunction is constructed, which exhibits excellent current rectification behavior with a rectification ratio of 1.8 × 103. Further, under the modulation of uniaxial tensile strain, a novel phenomenon that the dominant response waveband can be tuned from 550 to 800 nm by 1.04% tensile strain is observed. The maximum photoresponsivity to 800 nm incident laser reach 216.7 mA W−1 with 455% improvement has been demonstrated when a 1.04% tensile strain is applied. This work provides an example of multi‐band response light detection with strain manipulation on a single photodetector device, which shows significant prospect in adaptable artificial vision application.
Construction of Anthracene‐based Metal–Organic Framework Exhibiting Enhanced Singlet Oxygen Storage and Release Capabilities for Efficient Photodegradation of Phenolic Pollutants
Authors: Wei Wanyu , Yang Liujun , Zhang Long , Wang Shaoshuo , Pan Yicheng , Li Hua , Lu Jianmei 
Published: December 2024

AbstractControlling the generation and release of singlet oxygen (1O2) with high oxidation activity and long lifetime properties holds significant potential for efficient oxidation of permanent organic pollutants, tumor eradication, and targeted molecular oxidation. However, the conditions for controlled generation and release of 1O2 remain unclear. Hence, the novel anthracene‐ligands based Zr‐MOFs which use acetic acid (HAc) are constructed to optimize the surface defects and specific surface area exhibit ultrafast saturation adsorption capacity (362.60 mg g−1 in 60 s) and deep photodegradation performance toward bisphenol A (BPA) in water (50 ppm in 20 min) via Zr‐DPA MOF‐1HAc. Mechanistic studies have shown that MOFs are capable of generating high concentrations of 1O2, while anthracene ligands can rapidly store 1O2 and form endoperoxides (EPOs), which can be rapidly released under external light, heat, or chemical triggering conditions. Thus, high concentration of 1O2 is always involved in the oxidation reaction throughout the whole photodegradation process and ultimately achieves the complete mineralization of target phenolic pollutant molecules. This innovative strategy has important implications for generating, storing and controlling the release of 1O2 in the field of environmental engineering and chemical synthesis.
Highly Flexible and Ultralight PVA‐co‐PE‐AgNW/MXene Composite Film with Low Filling for Multistage Electromagnetic Interference Shielding
Authors: Tao Dechang , Yang Chenguang , Chen Can , Yan Kun , You Haining , Wang Wenwen , Wang Dong 
Published: December 2024

AbstractA composite film with multistage mechanisms for effective electromagnetic interference (EMI) shielding in the ultra‐wide frequency of 8–20 GHz was designed. Poly(vinyl alcohol‐co‐ethylene) (PVA‐co‐PE) nanofibers and twill‐structured nylon 6 fabric are used as substrate and filter film, respectively. Subsequently, a PVA‐co‐PE/silver nanowire (AgNW)/MXene (PVA/Ag/M) composite film is prepared by vacuum filtration, templating, and hot‐pressing. A 2.5 wt.% AgNW/MXene content, the EMI shielding efficiency (SE), normalized SE (SE/t), and absolute SE (SSE/t) are 101.6 dB, 7008.3 dB cm−1, and 36501.5 dB cm2 g−1, respectively. These results are attributed to the synergistic EMI shielding mechanisms enabled by the twill gradient structure and highly conductive. The surface twill structure promotes 95% wave adsorption, directing the wave along the film interior, significantly increasing the EM wave collision probability and internal reflection times. The rich number of hydrogen bonds increase the interfacial adhesion between the layers and enhance the tensile stress by up to 26.8 MPa. The PVA/Ag/M exhibits excellent Joule heating, rapid heat dissipation, non‐flammability, hydrophobicity, super‐flexibility, and stability. This paper presents an effective fabrication strategy for ultralight and highly conformable low‐filling films with high strength, excellent EMI SE, and outstanding thermal performance.
Aqueous Synthesis of Membrane Lipids via Amide Formation between Amphiphilic Amines and Thioacids
Authors: Chen Jiyue , Tanwar Lalita , Ji Peng , Brea Roberto J. , Devaraj Neal K. 
Published: December 2024

AbstractProtocell membranes were likely formed through primitive metabolic reactions that synthesized more complex membrane lipid species from simpler precursors. Thioacids have been shown to be prebiotically plausible and chemoselective N‐acylating reagents. They have been successfully employed for the acylation of peptides and RNA. However, the ability of thioacids to acylate lipid species has not yet been explored. Here, we demonstrate N‐acylation of natural amine‐containing amphiphiles using fatty thioacids. This reaction occurs spontaneously in aqueous conditions and is chemoselective,and traceless. The synthesis of several natural sphingolipids via direct N‐acylation is possible and their subsequent de novo formation into vesicular membranes is shown. Aqueous thioacid coupling provides a route for generating membrane‐forming lipids in the context of protocells and for the in situ synthesis of relevant sphingolipid species.