bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Tool to Monitor Adherence to Oral Oncolytics: A Pilot Study
Authors: Sun Wendy , Reeve Rebecca , Ouellette Timothy , Stutsky Martha , De Jesus Rachel , Huffer Michael J. , Mougalian Sarah S. 
Published: June 2021

PURPOSE Nonadherence is a significant issue in cancer care, especially as more oral therapies become available. Measuring and optimizing adherence to such therapies is challenging. In this study, we tested a novel technology that records real-time medication-taking behavior from a smart prescription bottle and can communicate with patients via text message to intervene in cases of nonadherence. METHODS We conducted a 28-patient pilot study to assess the feasibility of this technology in measuring and improving adherence in patients taking capecitabine, an oral chemotherapy agent with a complex, cyclical regimen. The study had a preintervention stage, during which patients were monitored, and an intervention stage, during which the text messaging intervention was enabled. RESULTS During preintervention, patients had an average self-adherence of 89%, and during post intervention, they had an average adherence of 90%. We defined three categories of patients by change in adherence: category 1 (> 8%), category 2 (−8% to 8%), and category 3 (< −8%). Patients in category 1 tended to live in regions with lower average household income (mean = $58,937 in US dollars [USD]) than those in category 2 (mean = $77,482 USD) and category 3 (mean = $90,972 USD). Of poststudy survey respondents, most indicated that they would want to continue using this technology and that they would recommend it to others. CONCLUSION This novel technology is able to monitor, measure, and intervene for patients taking capecitabine in real time. Adherence overall was high, and some patients appeared to benefit more from text-message interventions. Future work should focus on patients deemed high risk for nonadherence.
Respiratory dysfunction in a mouse model of spinocerebellar ataxia type 7
Authors: Fusco Anna F. , Pucci Logan A. , Switonski Pawel M. , Biswas Debolina D. , McCall Angela L. , Kahn Amanda F. , Dhindsa Justin S. , Strickland Laura M. , La Spada Albert R. , ElMallah Mai K. 
Published: June 2021

ABSTRACT
Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder caused by a CAG repeat expansion in the coding region of the ataxin-7 gene. Infantile-onset SCA7 patients display extremely large repeat expansions (&gt;200 CAGs) and exhibit progressive ataxia, dysarthria, dysphagia and retinal degeneration. Severe hypotonia, aspiration pneumonia and respiratory failure often contribute to death in affected infants. To better understand the features of respiratory and upper airway dysfunction in SCA7, we examined breathing and putative phrenic and hypoglossal neuropathology in a knock-in mouse model of early-onset SCA7 carrying an expanded allele with 266 CAG repeats. Whole-body plethysmography was used to measure awake spontaneously breathing SCA7-266Q knock-in mice at baseline in normoxia and during a hypercapnic/hypoxic respiratory challenge at 4 and 8 weeks, before and after the onset of disease. Postmortem studies included quantification of putative phrenic and hypoglossal motor neurons and microglia, and analysis of ataxin-7 aggregation at end stage. SCA7-266Q mice had profound breathing deficits during a respiratory challenge, exhibiting reduced respiratory output and a greater percentage of time in apnea. Histologically, putative phrenic and hypoglossal motor neurons of SCA7 mice exhibited a reduction in number accompanied by increased microglial activation, indicating neurodegeneration and neuroinflammation. Furthermore, intranuclear ataxin-7 accumulation was observed in cells neighboring putative phrenic and hypoglossal motor neurons in SCA7 mice. These findings reveal the importance of phrenic and hypoglossal motor neuron pathology associated with respiratory failure and upper airway dysfunction, which are observed in infantile-onset SCA7 patients and likely contribute to their early death.
Three-dimensional geometry controls division symmetry in stem cell colonies
Authors: Chaigne Agathe , Smith Matthew B. , Lopez Cavestany Rocio , Hannezo Edouard , Chalut Kevin J. , Paluch Ewa K. 
Published: June 2021

ABSTRACT
Proper control of division orientation and symmetry, largely determined by spindle positioning, is essential to development and homeostasis. Spindle positioning has been extensively studied in cells dividing in two-dimensional (2D) environments and in epithelial tissues, where proteins such as NuMA (also known as NUMA1) orient division along the interphase long axis of the cell. However, little is known about how cells control spindle positioning in three-dimensional (3D) environments, such as early mammalian embryos and a variety of adult tissues. Here, we use mouse embryonic stem cells (ESCs), which grow in 3D colonies, as a model to investigate division in 3D. We observe that, at the periphery of 3D colonies, ESCs display high spindle mobility and divide asymmetrically. Our data suggest that enhanced spindle movements are due to unequal distribution of the cell–cell junction protein E-cadherin between future daughter cells. Interestingly, when cells progress towards differentiation, division becomes more symmetric, with more elongated shapes in metaphase and enhanced cortical NuMA recruitment in anaphase. Altogether, this study suggests that in 3D contexts, the geometry of the cell and its contacts with neighbors control division orientation and symmetry.
This article has an associated First Person interview with the first author of the paper.
Determinants of climbing energetic costs in humans
Authors: Kozma Elaine E. , Pontzer Herman 
Published: June 2021

ABSTRACT
Previous studies in primates and other animals have shown that mass-specific cost of transport (J kg−1 m−1) for climbing is independent of body size across species, but little is known about within-species allometry of climbing costs or the effects of difficulty and velocity. Here, we assessed the effects of velocity, route difficulty and anatomical variation on the energetic cost of climbing within humans. Twelve experienced rock climbers climbed on an indoor wall over a range of difficulty levels and velocities, with energy expenditure measured via respirometry. We found no effect of body mass or limb proportions on mass-specific cost of transport among subjects. Mass-specific cost of transport was negatively correlated with climbing velocity. Increased route difficulty was associated with slower climbing velocities and thus higher costs, but there was no statistically significant effect of route difficulty on energy expenditure independent of velocity. Finally, human climbing costs measured in this study were similar to published values for other primates, suggesting arboreal adaptations have a negligible effect on climbing efficiency.
Temperature alone is insufficient to understand hibernation energetics
Authors: McGuire Liam P. , Johnson Emily M. , Frick Winifred F. , Boyles Justin G. 
Published: June 2021

ABSTRACT
Energy conservation has long been a focal point in hibernation research. A long-standing assumption is that ambient temperature (Ta) largely defines the rate of energy expenditure because of well-known relationships between Ta, metabolic rate and frequency of arousal from torpor. Body condition and humidity also affect energy expenditure but are usually considered secondary factors. We held tricolored bats (Perimyotis subflavus) in captivity under multiple environmental conditions to directly compare the importance of Ta, fat mass and humidity for hibernation energy expenditure. Fat mass was the best predictor of female mass loss, followed by Ta and humidity. However, males had less fat and adopted a more energetically conservative hibernation strategy. Our results demonstrate that understanding the evolution of behavior, physiology and ecology of hibernation requires disentangling the relative contributions of multiple drivers of hibernation energetics, and that Ta is not always the most important factor driving energy expenditure.
The effect of triple antibiotic paste as an intracanal medication with an anti-inflammatory drug on post-operative pain of asymptomatic uniradicular necrotic teeth: a double blind randomized clinical trial
Authors: Omaia Mohamed , Negm Maged , Nashaat Yousra , Nabil Nehal , Othman Amal 
Published: June 2021

Background:Flare-ups may occur after root canal treatment which consist of acute exacerbation of asymptomatic pulpal and/or periradicular pathologic condition. The causative factors of interappointment pain include mechanical, chemical or microbial irritation to the pulp or periradicular tissues. The potential role of microorganisms in interappointment pain is why the success of endodontic treatment depends on complete eradication of microorganisms capable of causing an intraradicular or extraradicular infection. This can be achieved by mechanical cleaning and shaping, in conjunction with irrigation and antibacterial agents. The aim of this study was to assess the ability of triple antibiotic paste with the anti-inflammatory drug diclofenac potassium versus calcium hydroxide used as an intra-canal medication in reducing post-operative pain.Methods:84 patients with asymptomatic uniradicular necrotic teeth were randomly assigned into two groups according to the intra-canal medication used: calcium hydroxide group (CH) and triple antibiotic paste with diclofenac potassium group (TAPC). In the first treatment session, intracoronal cavity preparation was performed after rubber dam isolation followed by chemo-mechanical preparation using rotary Protaper Universal files with saline irrigation followed by intra-canal medication placement then postoperative pain was assessed at 24, 48 and 72 hours postoperatively using Visual Analogue Scale (VAS). In the second treatment session, intracanal medications were removed by irrigation using saline followed by obturation.Results:Both intracanal medicaments resulted in a statistically significant decrease in mean pain value from 24 to 48 and 72 hours postoperatively. While when comparing both groups, TAPC intracanal medication showed less post-operative pain compared to that of the CH group at 24, 48 and 72 hours with a statistically significant difference at 48 hours only.Conclusion:Both intracanal medicaments were efficient in reducing post-operative pain in asymptomatic uniradicular necrotic teeth.Trial registration:Clinicaltrial.govNCT02907489, 20/09/2016.
Comparative cross-sectional assessment of knowledge, attitude and practice among university students and employees towards the use of the microbiology laboratory equipment
Authors: Muzaheed Muzaheed , El-Masry Omar S. , Rabaan Ali A. , Alzahrani Faisal , Alomar Amer , Farooqi Faraz Ahmed 
Published: June 2021

Background: Continuous evaluation of students and employee’s knowledge and attitude in clinical laboratories is mandatory to ensure a high level of competency, proper practice and to assess the need for training, which shall be reflected on the quality of laboratory results. The aim of the present study was to evaluate the knowledge, attitude, and practice in microbiology laboratories among employees (at King Fahd Hospital of the University) and clinical laboratory students (at Imam Abdulrahman Bin Faisal University) Methods: This was a cross-sectional survey of 30 2nd year students, 26 3rd year students, 24 4th year students in the Clinical Laboratory Sciences department, and 30 employees. Participants completed a survey comprising 30 questions to assess their knowledge and attitude towards the use of equipment and practice in the microbiology laboratory. Results: The results indicated that there was no significant difference between the average scores of all levels of students regarding their knowledge (p = 0.85, 0.999, and 0.869), attitude (p = 0.883, 0.996, 0.853), and practice (p=0.633, 0.325, 0.858) in the microbiology laboratory. Employees scores (knowledge;5.03±2.646, attitude; 12.03±4.89, and practice; 7.7±6.11) were quite poor, as indicated by the lower average results than that of students (knowledge; 5.65±3.08, attitude; 13.25±5.33, and practice; 13.46±5.7). Conclusions: It is concluded that the knowledge, attitude, and practice of students and employees in the microbiology laboratory needs to be meticulously monitored and improved to ensure high achievement of learning outcomes and better overall performance in the laboratory. This may be achieved through using frequent quizzes and continuous education programs.
Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): A Phase II Randomised Controlled trial: Trial Protocol
Authors: Olupot-Olupot Peter , Aloroker Florence , Mpoya Ayub , Mnjalla Hellen , Passi George , Nakuya Margaret , Houston Kirsty , Obonyo Nchafatso , Hamaluba Mainga , Evans Jennifer A , Connon Roisin , George Elizabeth C , Gibb Diana M , Maitland Kathryn 
Published: June 2021

Background: Children hospitalised with severe acute malnutrition (SAM) are frequently complicated (>50%) by diarrhoea (≥3 watery stools/day) which is accompanied by poor outcomes. Rehydration guidelines for SAM are exceptionally conservative and controversial, based upon expert opinion. The guidelines only permit use of intravenous fluids for cases with advanced shock and exclusive use of low sodium intravenous and oral rehydration solutions (ORS) for fear of fluid and/or sodium overload. Children managed in accordance to these guidelines have a very high mortality. The proposed GASTROSAM trial is the first step in reappraising current recommendations. We hypothesize that liberal rehydration strategies for both intravenous and oral rehydration in SAM children with diarrhoea may reduce adverse outcomes. Methods An open Phase II trial, with a partial factorial design, enrolling Ugandan and Kenyan children aged 6 months to 12 years with SAM hospitalised with gastroenteritis (>3 loose stools/day) and signs of moderate and severe dehydration. In Stratum A (severe dehydration) children will be randomised (1:1:2) to WHO plan C (100mls/kg Ringers Lactate (RL) with intravenous rehydration given over 3-6 hours according to age including boluses for shock), slow rehydration (100 mls/kg RL over 8 hours (no boluses)) or WHO SAM rehydration regime (ORS only (boluses for shock (standard of care)). Stratum B incorporates all children with moderate dehydration and severe dehydration post-intravenous rehydration and compares (1:1 ratio) standard WHO ORS given for non-SAM (experimental) versus WHO SAM-recommended low-sodium ReSoMal. The primary outcome for intravenous rehydration is urine output (mls/kg/hour at 8 hours post-randomisation), and for oral rehydration a change in sodium levels at 24 hours post-randomisation. This trial will also generate feasibility, safety and preliminary data on survival to 28 days. Discussion. If current rehydration strategies for non-malnourished children are safe in SAM this could prompt future evaluation in Phase III trials.
Radiation Risk Assessment in Patients for Chest CT Diagnostics of COVID-19
Authors: Matkevich E. 
Published: June 2021

Purpose: To assess effective radiation doses for chest CT for the diagnosis of COVID-19 and calculate the radiation risk of the effects of this exposure.
Material and methods: We analyzed the results of 1003 CT examinations of the chest performed in patients (6.2 %‒children 12–14 years, 15.3 %‒adolescents 15–19 years, 60.1 %‒adults 20–64 years, 18.4 %‒older persons 65 years and older) with suspected COVID-19 during one week in October 2020 in the city diagnostic center. In each group, the average effective dose (ED, mSv) was calculated.
Results: The average ED values and confidence intervals (P=0.05) for patients with a single CT scan were: in children 2.59±0.19 mSv, in adolescents 3.23±0.17 mSv, in adults 3.43±0.08 mSv, in older persons 3.28±0.19 mSv. The maximum radiation risk indicators were observed in groups of children (24.1×10-5) and adolescents (23.3×10-5). For adult patients the means risk was 14.4×10-5. In groups of women radiation risk was 1.3–2.3 twice as high, as in male patients. The risk values in children, adolescents and adults are in the range 10×10-5 – 100×10-5 (low), for the older patients were 2.6×10-5 (very low).
Conclusion: Because of the study established effective radiation doses for chest CT of patients with the diagnosis of COVID-19 and the radiation risk for 1-3 times chest CT by age and sex of patients was calculated. It was found that the radiation risk for single, double and triple chest CT for patients under 65 is low, 65 and older is very low. Taking into account the radiation risk during CT is necessary to reduce the long-term consequences of radiation exposure on the population.
To the Question of Maintaining the Professional Health of Staff in Educational Organizations
Authors: Perederiy V. , Skripnichenko L. 
Published: June 2021

The article highlights the health issues, the problem of improving its parameters, which are directly related to the stable development of modern society. This topic is especially significant in the context of socio-economic instability, high inflation, rising prices for various goods and services, and the problems of implementing health policies. The physical potential and health status of the individual have a significant impact on the main areas of society, types of social and personal communications, are a source of using the appropriate channels for self-realization, preserving environmental safety. The health of employees is deteriorating under the influence of a number of factors: environmental pollution, poverty, quality of food, smoking, alcoholism, drug addiction, etc. Changes in society draw the attention of government bodies to public health problems and contribute to more productive and thorough work with labor resources.
By "professional health" the authors of the article mean a complex of psychophysiological and psychosocial individual qualities of workers that meet working conditions and ensure high efficiency of professional activity. The state of professional health of the personnel is associated with the absence of any deformations, representing the absolute psychophysical and social well-being of a person in working conditions. Simultaneously with professional health, modern researchers pay special attention to the psychological component of workers' health. Aspects such as constant overstrain, nervous and psychophysical overloads are of great interest to specialists in this field. Among the main causes of industrial accidents, overworking of workers is in the first place. The energy expenditure of workers in carrying out production tasks must be compatible with well-being. The health of the personnel is an economic value, since the efficiency and quality of labor activity of the entire enterprise depend on the efficiency, labor potential, involvement of employees in the labor process as a whole.
Single LED positioning scheme based on angle sensors in robotics
Authors: Huang Linyi , Wen Shangsheng , Yan Zihong , Song Hongzhan , Su Shuomiao , Guan Weipeng 
Published: June 2021

Indoor robotic localization is one of the most active areas in robotics research nowadays. Visible light positioning (VLP) is a promising indoor localization method, as it provides high positioning accuracy and allows for leveraging the existing lighting infrastructure. Apparently, accurate positioning performance is mostly shown by the VLP system with multiple LEDs, while such strict requirement of LED numbers is more likely to lead to VLP system failure in actual environments. In this paper, we propose a single-LED VLP system based on image sensor with the help of angle sensor estimation, which efficiently relaxes the assumption on the minimum number of simultaneously captured LEDs from several to one. Aiming at improving the robustness and accuracy of positioning in the process of continuous change of robot pose, two methods of visual-inertial message synchronization are proposed and used to obtain the well-matched positioning data packets. Various schemes of single-LED VLP system based on different sensor selections and message synchronization methods have been listed and compared in an actual environment. The effectiveness of the proposed single-LED VLP system based on odometer and image sensor as well as the robustness under LED shortage, handover situation and background non-signal light interference, are verified by real-world experiments. The experimental results show that our proposed system can provide an average accuracy of 2.47 cm and the average computational time in low-cost embedded platforms is around 0.184 s.
All-fiber probes for endoscopic optical coherence tomography of the large airways
Authors: Balakrishnan Santosh , Oldenburg Amy L. 
Published: June 2021

Endoscopic optical coherence tomography of large airways poses unique challenges. A hybrid lens is described that consists of a section of coreless fiber and graded index fiber (GIF), followed by a ball lens section. This design produces low numerical aperture beams better suited for large airway imaging. The performance of this lens is compared against conventional GIF and ball lens designs. Forward- and side-viewing probes were modeled, fabricated, and tested. The impact of a sheath on the beam profile was also investigated. Probes with working distances larger than 10 mm and depth-of-focus exceeding 12 mm are demonstrated with the proposed design.
3.25  kW all-fiberized and polarization-maintained Yb-doped amplifier with a 20  GHz linewidth and near-diffraction-limited beam quality
Authors: Wang Yanshan , Sun Yinhong , Peng Wanjing , Feng Yujun , Wang Jue , Ma Yi , Gao Qingsong , Zhu Rihong , Tang Chun 
Published: June 2021

In this paper, we demonstrate a high-power, narrow-linewidth, polarization-maintaining fiber amplifier with near-diffraction-limited beam quality. By optimizing the phase modulation signal, a nearly top-hat-shaped spectrum was generated for self-pulsing suppressing. That results in doubling the self-pulsing threshold we got from conventional white noise signal phase modulation with the same optical linewidth. Based on an optimized signal and a high power, polarization-maintaining, counter-pumped fiber amplifier, we obtain a 3.25 kW narrow-linewidth linearly polarized laser output with a linewidth of

∼

20

G
H
z

, the polarization extinction ratio is about 15 dB, and the

M
2

is less than 1.22 at the maximum output power. To the best of our knowledge, this is the first demonstration of a narrow-linewidth, linear polarization, all-fiber amplifier with 3.25 kW laser output.
High-resolution range profile reconstruction method for terahertz FMCW radar
Authors: Hu Weidong , Li Yade , Han Zhongde , Xu Zhihao , Zhao Yunzhang , Ni Jiaqi 
Published: June 2021

Terahertz (THz) testing, by the frequency modulated continuous wave (FMCW) system, is often hampered by the limited range resolution. Thus, in this paper, a software method is proposed to reconstruct the range profile, yielding significant improvements in range resolution and in signal parameter extraction. Specifically, the multiple signal characterization algorithm is first introduced to indicate a higher-resolution range profile qualitatively and to acquire the echoes’ initial values. Then, multiple Gaussian functions are applied to fit those echoes in the whole original range profile and to accurately extract the parameters, including the amplitude, range, and width, of each echo. Finally, with these parameters, the range profile can be more precisely and flexibly reconstructed, facilitating the following detection procedure to a great extent. Both the simulated and the real THz data, acquired by a 150–220 GHz FMCW imager, have been used to demonstrate the superiority and effectiveness of our method, qualitatively and quantitatively.