bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of Hypertensive Disorders of Pregnancy
Authors: Zahan Akhter , Islam Md Nazrul , Sharma Netay Kumer , Begum Khadiza , Bhowmik Kinkon Rani 
Published: May 2021

Hypertension is the most common medical problem encountered in pregnancy and are leading causes of maternal, fetal and neonatal morbidity and mortality worldwide. Definitions, classifications, assessment and management of hypertensive disorders vary considerably in the literature and from country to country. In light of this, we aimed to evaluate different types of hypertensive disorders of pregnancy and to determine the impact of hypertensive disorders of pregnancy (HDP) on maternal, fetal and neonatal outcomes. This Cross Sectional descriptive study was conducted in the Department of Gynaecology and Obstetrics of Community Based Medical College, Mymensingh, Bangladesh from April 2012 to March 2013. All the patients who were diagnosed with HDP and gestational age of 20-40 weeks during the study period were included in the study. Patients with preexisting renal disease, diabetes mellitus, active urinary tract infection or who refused to cooperate with the study were excluded. The data regarding demographic variables, clinical features, pregnancy characteristics, maternal complications, fetal and neonatal outcomes were gathered from available data on medical record files. Edema was the most common clinical symptom. Primipara mothers were predominant in the both mild and severe preeclampsia group. Majority (88%) of mothers in mild preeclampsia group had a history of spontaneous vaginal birth, however 82.9% in severe preeclampsia group by Lower Segment Caesarean Section (LSCS). A higher proportion of mother in mild preeclampsia group delivered at term, whereas 65.7% in severe preeclampsia group delivered preterm. The proportion of maternal complications such as were significantly higher in severe preeclampsia group than those in mild preeclampsia group. Most babies (92%) were born with a birth weight 2500 grams in mild preeclampsia group, while 70% born with birth weight between 1500 - 2499 grams in severe preeclampsia group. All the babies were born with apgar score less than 7 between mild and severe preeclampsia groups. About three quarter (74.3%) of neonates born to women the severe preeclampsia group required resuscitation compared to 40% in mild preeclampsia group. The maternal death, still birth and neonatal death were found higher in severe preeclampsia group than those in mild preeclampsia group. Pregnancies affected by hypertensive disorders require careful monitoring due to the increased risks of adverse pregnancy outcomes. Frequency of severe hypertensive disorders is high in our set up. It is associated with high maternal, fetal and neonatal mortality
CBMJ 2014 January: Vol. 03 No. 01 P: 46-52
Studi Kasus Asuhan Kebidanan pada Ibu Bersalin dengan Preeklampsi Berat di RSUD Ciamis
Authors: Heryani Heni 
Published: May 2021

One of the main causes of maternal mortality is severe preeclampsia. Severe absorption is an increase in blood pressure and proteinuria that occurs after 20 weeks of gestation. If severe preeclampsia is not treated quickly and precisely, it can turn into eclampsia. The purpose of this study was to provide an overview of the midwifery care of maternity women with severe preeclampsia at Ciamis Regional Hospital. The research method used was descriptive qualitative with a case study approach. The subjects in this study were Mrs. E, 32 years old with severe preeclampsia. This research was conducted from 5 to 6 March 2020 at Ciamis Hospital. The results of research on Mrs. E age 32 years G2P1A0 37 weeks of active phase 1 labor with severe preeclampsia of live single fetus. Handling carried out on Mrs. E has been carried out in accordance with the care plan that has been made. Midwives carry out midwifery care in accordance with midwifery care standards starting from assessment, formulation of midwifery diagnoses or problems, planning, implementation and evaluation.
Keywords: maternity; severe preeclampsia

ABSTRAK

Salah satu penyebab utama dari angka kematian ibu adalah preeklamsia berat. Preeklampsia berat adalah peningkatan tekanan darah dan proteinuria yang terjadi setelah usia kehamilan 20 minggu. Jika preeklampsi berat tidak segera ditangani dengan cepat dan tepat maka hal ini dapat berubah menjadi eklampsia. Tujuan Penelitian ini adalah untuk memberikan gambaran tentang Asuhan Kebidanan pada Ibu Bersalin dengan Preeklampsia Berat di RSUD Ciamis. Metode penelitian yang digunakan adalah deskriptif kualitatif dengan pendekatan studi kasus. Subjek dalam penelitian ini adalah Ny. E umur 32 tahun dengan Preeklampsia Berat (PEB). Penelitian ini dilakukan mulai tanggal 5 sampai dengan 6 maret 2020 yang bertempat di RSUD Ciamis. Hasil penelitian pada Ny. E umur 32 tahun G2P1A0 37 minggu persalinan kala 1 fase aktif dengan Preeklampsia Berat (PEB) janin tunggal hidup, Penanganan yang dilakukan pada Ny. E telah dilakukan sesuai dengan rencana asuhan yang telah dibuat. Bidan melakukan asuhan kebidanan sesuai dengan standar asuhan kebidanan mulai dari pengkajian, perumusan diagnosa atau masalah kebidanan, perencanaan, implementasi dan evaluasi.
Kata kunci: ibu bersalin; preeklamsia berat
Diabetes Mellitus dengan Status Gizi (Underweight) dalam Meningkatkan Resiko Kasus Tuberkulosis : Studi Kasus Kontrol di Puskesmas Mulyorejo
Authors: Marbun Romaden , Widi Wisoedhanie , Dea Vincensia 
Published: May 2021

The incidence and prevalence of tuberculosis (TB) and Diabetes Mellitus (DM) now is increasing rapidly in the world. The International Diabetes Federation reports that people with Diabetes Mellitus have a higher risk of developing tuberculosis. There are several risk factors that are thought to increase the incidence of tuberculosis, one of which is Diabetes Mellitus (DM). This study aims to determine the relations between DM and the incidence of TB at Puskesmas Mulyorejo Malang. The research design was case control. The sample consisted of 114 respondents covering 57 for the control group and 57 for the case group. Data analysis using logistic regression. In the tuberculosis group, the percentage of respondents with DM was 64.9%, while in the group who did not suffer from tuberculosis, the percentage of respondents with DM was 24.6%. In this study, DM interacted with nutritional status (underweight). Means, at the same smoking habit, the relationship between DM and TB incidence is different according to the nutritional status of the respondent. For the underweight respondents, DM has a 20.0 times higher chance of developing TB than respondents who do not have diabetes. For the future, the researchers who will conduct similar research can discusse more and also improve this research with broader research variables in form of correlation. Diabetes mellitus is a disease that can cause a decrease in the cellular immune system.
Keywords: diabetes mellitus; tuberculosis

ABSTRAK

Insidensi dan prevalensi penyakit tuberkulosis (TB) dan Diabetes Mellitus (DM) meningkat cepat di dunia. International Diabetes Federation melaporkan penderita Diabetes Mellitus berisiko lebih tinggi untuk berkembang menjadi tuberkulosis. Terdapat beberapa faktor resiko yang diduga dapat meningkatkan kejadian Tuberkulosis, salah satunya adalah Diabetes Mellitus (DM) Penelitian ini bertujuan untuk mengetahui Hubungan antara DM dengan kejadian TB di Puskesmas Mulyorejo Malang. Desain penelitian adalah case control. Sampel berjumlah 114 responden yang meliputi 57 untuk kelompok kontrol dan 57 untuk kelompok kasus. Analisis Data menggunakan regresi logistik. Pada kelompok tuberkulsosis, presentase responden dengan DM sebesar 64,9%, sedangkan pada kelompok yang tidak menderita tuberkulosis, persentase responden dengan DM sebesar 24,6%. Pada penelitian ini, DM berinteraksi dengan status gizi (underweight). Artinya, pada kebiasaan merokok yang sama, hubungan DM dengan kejadian TB berbeda menurut status gizi responden. Pada responden yang underweight, DM memiliki peluang 20,0 kali lebih tinggi untuk terjadi TB dibandingkan responden yang tidak DM. Diabetes mellitus merupakan suatu penyakit yang dapat menyebabkan penurunan sistem imunitas selular.
Kata kunci: diabetes melitus; tuberkulosis
Studi Kasus : Manajemen Asuhan Kebidanan Pada Ibu Bersalin Dengan Persalinan Prematur di RSUD Ciamis
Authors: Lestari Lusi 
Published: May 2021

Premature labor or premature contractions are the main causes of perinatal death and one of the most common causes of disability in children due to poor neurodevelopment. Preterm labor is a dangerous thing because it has the potential to increase perinatal mortality by 65% -75%. The purpose of this study was to provide an overview of the midwifery care of maternity women with premature contractions at Ciamis Regional Hospital. The research method used in this research was a descriptive qualitative method with an individual case study approach. The subjects in this study were Mrs. Y Age 26 Years G2P1A0 with Premature Contractions. The research was conducted in a day on March 5, 2020, at Ciamis Hospital. The results showed an intervention was made in accordance with the midwifery care plan is based on the theory and client needs. Midwives in providing care in accordance with the authority of the midwife. The evaluation results obtained that Mrs. Y had no complaints, TTV was within normal limits.
Keywords: midwifery care; premature contractions

ABSTRAK

Persalinan prematur atau prematur kontraksi adalah penyebab utama kematian perinatal dan merupakan salah satu penyebab terbanyak kecacatan pada anak akibat perkembangan saraf yang tidak baik. Persalinan prematur merupakan hal yang berbahaya karena potensial meningkatkan kematian perinatal sebesar 65%-75%. Tujuan penelitian ini adalah untuk memberikan gambaran tentang Asuhan Kebidanan pada Ibu Bersalin dengan Prematur Kontraksi di RSUD Ciamis. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan pendekatan studi kasus pada individu. Subjek dalam penelitian ini adalah Ny. Y umur 26 Tahun G2P1A0 dengan Prematur Kontraksi. Waktu pelaksanaan penelitian selama 1 hari pada tanggal 5 Maret 2020 di RSUD Ciamis. Hasil penelitian menunjukkan penanganan dilakukan sesuai dengan rencana asuhan kebidanan yang dibuat berdasarkan teori dan kebutuhan klien. Bidan dalam memberikan asuhan sesuai dengan kewenangan bidan. Hasil evaluasi diperoleh Ny.Y sudah tidak ada keluhan, TTV dalam batas normal.
Kata kunci: asuhan kebidanan; prematur kontraksi
Literature Review : Evaluasi Peer Group Support dan Family Support Terhadap Kepatuhan Pengobatan Pada Pasien Tuberkulosis Paru
Authors: Suarnianti Suarnianti , Selan Chairul Hasan , Sumi Susi Sastika 
Published: May 2021

Tuberculosis (TB) is an infectious disease which is the leading cause of ill health, one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent (ranking above HIV / AIDS). WHO estimates that there are 23,000 cases of MDR / RR in Indonesia. In 2017 there were 442,000 TB cases recorded in the program, of which an estimated 8,600-15,000 MDR / RR TB, (estimated 2.4% of new cases and 13% of previously treated TB patients), but only 27.36% treated. The aim of this literature is to evaluate peer group support and family support on treatment adherence to pulmonary tuberculosis patients. This study used a systematic literature review design. Articles were collected through the PubMed and Google Scholar databases published from 2016-2020 using the keywords peer group support, family support, medication adherence, pulmonary tuberculosis. The results of the literature review showed that providing peer group support or family support can have an impact positive for pulmonary tuberculosis patients. The conclusion in this study is that patients who get support from either peer group support or family support can significantly improve compliance with pulmonary tuberculosis treatment so that it can increase the success rate of pulmonary tuberculosis treatment.
Keywords: peer group support; family support; treatment compliance; pulmonary tuberculosis

ABSTRAK

Tuberkulosis (TB) adalah penyakit menular yang merupakan penyebab utama masalah kesehatan yang buruk, salah satu dari 10 penyebab utama kematian di seluruh dunia dan penyebab utama kematian dari satu agen infeksi tunggal (peringkat di atas HIV / AIDS). WHO memperkirakan ada 23.000 kasus MDR/RR di Indonesia. Pada tahun 2017 kasus TB yang tercatat di program ada sejumlah 442.000 kasus yang mana dari kasus tersebut diperkirakan ada 8.600-15.000 MDR/RR TB, (perkiraan 2,4% dari kasus baru dan 13% dari pasien TB yang diobati sebelumnya), tetapi cakupan yang diobati baru sekitar 27,36%. Tujuan Literatur ini untuk mengevaluasi peer group support dan family support terhadap kepatuhan pengobatan pasien tuberkulosis paru. Penelitian ini menggunakan desain systematic literature review. Artikel dikumpulkan melalui database PubMed dan Google Scholar yang dipublikasikan dari tahun 2016-2020 dengan menggunakan kata kunci peer group support, family support, kepatuhan pengobatan, tuberkulosis paru. Hasil literature review menunjukkan bahwa pemberian peer group support atau family support dapat memberikan dampak yang positif kepada pasien tuberkulosis paru. Kesimpulan dalam penelitian ini bahwa pasien yang mendapatkan dukungan baik peer group support atau family support secara signifikan dapat meningkatkan kepatuhan pengobatan tuberkulosis paru sehingga dapat meningkatkan tingkat keberhasilan pengobatan tuberkulosis paru
Kata kunci: peer group support; family support; kepatuhan pengobatan; tuberkulosis paru
Perbedaan Sonopattern Ultrasonografi Kandung Empedu pada Kasus Cholelithiasis & Galbladder Polyp
Authors: Fiddinillah Fiddinillah , Sriyatun Sriyatun , Nurbaiti Nurbaiti , Apriantoro Nursama Heru 
Published: May 2021

On ultrasound examination of the gallbladder Cholelithiasis and Gallbladder Polyp usually have similar results but have their own characteristics that can differentiate. In the image results Cholelithiasis, which is usually called gallstones, has a characteristic Sonopattern Hyperechoic with an Acousstic Shadow behind it, where when using the technique the patient's position changes the stone according to the direction of Earth's gravity. While the results of the Gallbladder Polyp image, which is a tumor protrusion attached to the gallbladder wall, has the characteristic Sonopattern Hyperecoic without an acoustic shadow behind it, where when using the technique the patient's position changes not according to the direction of Earth's gravity. In both cases, the presence or absence of an acoustic shadow behind it is based on the density of the tissue that the sound waves pass through from the ultrasound device, so that when passing through the stone, the acoustic shadow is more visible than when passing through the tumor tissue..
Keywords: sonopattern ultrasound; cholelithiasis; gallbladder polyp

ABSTRAK

Pada pemeriksaan USG kandung empedu Cholelithiasis dan Gallbladder Polyp biasanya memiliki hasil gambaran yang serupa tetapi memiliki ciri khasnya masing-masing yang dapat membedakan. Pada hasil gambaran Cholelithiasis yang biasa disebut batu empedu memiliki ciri khas Sonopattern Hyperechoic dengan Acousstic Shadow di belakangnya, ketika menggunakan teknik dengan posisi pasien yang berubah batu mengikuti arah gravitasi bumi. Sementara pada hasil gambaran Gallbladder Polyp yang merupakan tonjolan tumor yang menempel pada dinding kandung empedu memiliki ciri khas Sonopattern Hyperecoic tanpa Accoustic Shadow dibelakangnya, dimana ketika menggunakan teknik dengan posisi pasien yang berubah tidak mengikuti arah gravitasi bumi. Pada kedua kasus ini ada tidaknya Accoustic Shadow di belakangnya didasari oleh kepadatan jaringan yang dilalui oleh gelombang suara dari alat USG, sehingga saat melewati batu lebih tampak Accoustic Shadow dibandingkan saat melewati jaringan tumor.
Kata kunci: sonopattern ultrasound; cholelithiasis; gallbladder polyp
Small Intestinal Bacterial Overgrowth in Subclinical Hypothyroidism of Pregnant Women
Authors: Wang Biao , Xu Yajuan , Hou Xiaofeng , Li Jingjing , Cai Yanjun , Hao Yingqi , Ouyang Qian , Wu Bo , Sun Zongzong , Zhang Miao , Ban Yanjie 
Published: May 2021

ObjectiveTo evaluate the small intestinal bacterial overgrowth (SIBO) of subclinical hypothyroidism of pregnant women, and explore their possible relevance.MethodsIn total, 224 pregnant women with subclinical hypothyroidism during pregnancy (study group) and 196 pregnant women whose thyroid function was normal (control group) were enrolled in this study. Lactulose-based hydrogen and methane breath test was performed to evaluate the growth of intestinal bacteria. The serum-free thyroid hormone (FT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), body mass index (BMI) and gastrointestinal symptoms were detected and recorded.ResultsThe positive rates of SIBO were 56.7% and 31.6% in study group and control group, respectively. The levels of C response protein (CRP), abdominal distension and constipation in study group were higher than those in the control group. The risk of abdominal distension and constipation in SIBO-positive pregnant women were higher than that in SIBO-negative pregnant women, and the BMI of SIBO-positive patients in the two groups was lower than that of SIBO-negative patients in each group. In addition, the TPOAb-positive rate and TSH levels were higher but the FT4 level was lower in SIBO-positive patients compared to SIBO-negative patients in study group.ConclusionThe occurrence of subclinical hypothyroidism is related to SIBO, and the excessive growth of small intestinal bacteria may affect gastrointestinal symptoms.Clinical Trialhttp://www.chictr.org.cn/index.aspx, identifier ChiCTR1900026326.
Adults’ Adherence to Growth Hormone Replacement in Relation to Medication-Related Beliefs, Coping and Quality of Life - An Exploratory Analysis
Authors: Siegel Sonja , Unger Nicole , Streetz-van der Werf Christine , Karges Wolfram , Schilbach Katharina , Schröder Bernadette , Szybowicz Janine , Sauerwald Janina , Zopf Kathrin , Grzywotz Agnieszka , Bidlingmaier Martin , Kirstein Cedric , Sommer Heide , Strasburger Christian J. , Kreitschmann-Andermahr Ilonka 
Published: May 2021

IntroductionLittle is known about psychological reasons associated with adherence to growth hormone (GH) replacement therapy (GHRx) in adults. As in other chronic diseases, medication-related beliefs, coping strategies and disease impact on quality of life (QoL) might play an important role. We thus explored these psychological factors in relation to adherence in patients with GH deficiency (GHD) in order to find leverage points for the improvement of adherence.Patients and MethodsCross-sectional analysis including 107 adult GHD patients on GHRx who completed self-assessment inventories on health-related QoL (Short-Form SF-36), coping style (Freiburg questionnaire on coping with illness, FKV-LIS) and medication beliefs (Beliefs about Medicine questionnaire, BMQ). Results were correlated to general and GH-specific adherence to medication.ResultsIn the BMQ, 92.5% of the patients (n=99) reported a strong belief in the need for their medication, which correlated significantly with general adherence (rs = 0.325). Active coping was significantly related to general (rs = 0.307) and GH-specific adherence (rs = 0.226). Better mental QoL (rs = 0.210) but worse physical QoL (rs = -0.198; all p &lt; 0.05) were related to higher GH-specific adherence. Older age was associated with a higher degree of active coping, a higher belief in the necessity of medication and worse physical QoL.ConclusionWe provide preliminary data that most GHD patients on GHRx are strongly convinced of their need for medication and that adherence to GHRx is influenced by coping strategies and QoL. Patients with impaired psychological QoL are less able to translate their convictions into good adherence, a phenomenon to be addressed in future research.
Functional Polymorphism in the NFE2L2 Gene Associated With Tuberculosis Susceptibility
Authors: Ji Guiyi , Zhang Miaomiao , Liu Qianqian , Wu Shouquan , Wang Yu , Chen Guo , Sandford Andrew J. , He Jian-Qing 
Published: May 2021

BackgroundNuclear transcription factor erythroid 2 p45-related factor 2 (Nrf2), encoded by NFE2L2, functions as a key transcription factor and regulates expression of antioxidant genes. Our study aimed to investigate the association of single nucleotide polymorphisms of NFE2L2 with tuberculosis (TB) and latent tuberculosis infection (LTBI) and the underlying causal mechanisms.Methods1950 unrelated Chinese Han participants were included in our two independent study groups. Five tag polymorphisms were selected and genotyped. The functional effects of the rs13005431 polymorphism were confirmed by dual-luciferase reporter assays and mRNA level comparisons.ResultsRs13005431_C and rs2364723_G were associated with increased TB susceptibility (P = 0.010 and P = 0.041) after adjustment for confounding factors. rs6726395_A was associated with increased risk of active TB (P=0.035) in a comparison with the LTBI group. The frequency of haplotype rs1049751- rs13005431 AC was higher in the TB group (P =0.013), while frequency of haplotype AT was higher in the healthy control group (P =0.025). The luciferase activity of a plasmid with the rs13005431C-promoter was significantly lower than that of the rs13005431T-promoter. In addition, neutrophils with the CC/TC genotypes which were activated by GM-CSF showed a decreased level of NFE2L2 mRNA when compared with the rs13005431 TT genotype.ConclusionsOur study suggests that allele C of rs13005431 might increase the susceptibility to TB by down-regulating the transcriptional activity of NFE2L2.
Integration of Immunome With Disease-Gene Network Reveals Common Cellular Mechanisms Between IMIDs and Drug Repurposing Strategies
Authors: Devaprasad Abhinandan , Radstake Timothy R. D. J. , Pandit Aridaman 
Published: May 2021

ObjectiveDevelopment and progression of immune-mediated inflammatory diseases (IMIDs) involve intricate dysregulation of the disease-associated genes (DAGs) and their expressing immune cells. Identifying the crucial disease-associated cells (DACs) in IMIDs has been challenging due to the underlying complex molecular mechanism.MethodsUsing transcriptome profiles of 40 different immune cells, unsupervised machine learning, and disease-gene networks, we constructed the Disease-gene IMmune cell Expression (DIME) network and identified top DACs and DAGs of 12 phenotypically different IMIDs. We compared the DIME networks of IMIDs to identify common pathways between them. We used the common pathways and publicly available drug-gene network to identify promising drug repurposing targets.ResultsWe found CD4+Treg, CD4+Th1, and NK cells as top DACs in inflammatory arthritis such as ankylosing spondylitis (AS), psoriatic arthritis, and rheumatoid arthritis (RA); neutrophils, granulocytes, and BDCA1+CD14+ cells in systemic lupus erythematosus and systemic scleroderma; ILC2, CD4+Th1, CD4+Treg, and NK cells in the inflammatory bowel diseases (IBDs). We identified lymphoid cells (CD4+Th1, CD4+Treg, and NK) and their associated pathways to be important in HLA-B27 type diseases (psoriasis, AS, and IBDs) and in primary-joint-inflammation-based inflammatory arthritis (AS and RA). Based on the common cellular mechanisms, we identified lifitegrast as a potential drug repurposing candidate for Crohn’s disease and other IMIDs.ConclusionsExisting methods are inadequate in capturing the intricate involvement of the crucial genes and cell types essential to IMIDs. Our approach identified the key DACs, DAGs, common mechanisms between IMIDs, and proposed potential drug repurposing targets using the DIME network. To extend our method to other diseases, we built the DIME tool (https://bitbucket.org/systemsimmunology/dime/) to help scientists uncover the etiology of complex and rare diseases to further drug development by better-determining drug targets, thereby mitigating the risk of failure in late clinical development.