bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aortic Stiffness Hysteresis in Isolated Mouse Aortic Segments Is Intensified by Contractile Stimuli, Attenuated by Age, and Reversed by Elastin Degradation
Authors: De Moudt Sofie , Leloup Arthur , Fransen Paul 
Published: September 2021

Aim: Cyclic stretch of vascular tissue at any given pressure reveals greater dimensions during unloading than during loading, which determines the cardiac beat-by-beat hysteresis loop on the pressure-diameter/volume relationship. The present study did not focus on hysteresis during a single stretch cycle but investigated whether aortic stiffness determined during continuous stretch at different pressures also displayed hysteresis phenomena.Methods: Aortic segments from C57Bl6 mice were mounted in the Rodent Oscillatory Set-up for Arterial Compliance (ROTSAC), where they were subjected to high frequency (10 Hz) cyclic stretch at alternating loads equivalent to a constant theoretical pulse pressure of 40 mm Hg. Diastolic and systolic diameter, compliance, and the Peterson elastic modulus (Ep), as a measure of aortic stiffness, was determined starting at cyclic stretch between alternating loads corresponding to 40 and 80 mm Hg, at each gradual load increase equivalent to 20 mm Hg, up to loads equivalent to pressures of 220 and 260 mm Hg (loading direction) and then repeated in the downward direction (unloading direction). This was performed in baseline conditions and following contraction by α1 adrenergic stimulation with phenylephrine or by depolarization with high extracellular K+ in aortas of young (5 months), aged (26 months) mice, and in segments treated with elastase.Results: In baseline conditions, diastolic/systolic diameters and compliance for a pulse pressure of 40 mm Hg were larger at any given pressure upon unloading (decreasing pressure) than loading (increasing pressure) of the aortic segments. The pressure-aortic stiffness (Ep) relationship was similar in the loading and unloading directions, and aortic hysteresis was absent. On the other hand, hysteresis was evident after activation of the VSMCs with the α1 adrenergic agonist phenylephrine and with depolarization by high extracellular K+, especially after inhibition of basal NO release with L-NAME. Aortic stiffness was significantly smaller in the unloading than in the loading direction. In comparison with young mice, old-mouse aortic segments also displayed contraction-dependent aortic hysteresis, but hysteresis was shifted to a lower pressure range. Elastase-treated segments showed higher stiffness upon unloading over nearly the whole pressure range.Conclusions: Mouse aortic segments display pressure- and contraction-dependent diameter, compliance, and stiffness hysteresis phenomena, which are modulated by age and VSMC-extracellular matrix interactions. This may have implications for aortic biomechanics in pathophysiological conditions and aging.
Human Physiological Responses to a Single Deep Helium-Oxygen Diving
Authors: Bao Xiao-Chen , Shen Quan , Fang Yi-Qun , Wu Jian-guo 
Published: September 2021

Objective: The objective of this study was to explore whether a single deep helium-oxygen (heliox) dive affects physiological function.Methods: A total of 40 male divers performed an open-water heliox dive to 80 m of seawater (msw). The total diving time was 280 min, and the breathing helium-oxygen time was 20 min. Before and after the dive, blood and saliva samples were collected, and blood cell counts, cardiac damage, oxidative stress, vascular endothelial activation, and hormonal biomarkers were assayed.Results: An 80 msw heliox dive induced a significant increase in the percentage of granulocytes (GR %), whereas the percentage of lymphocytes (LYM %), percentage of intermediate cells (MID %), red blood cell number (RBC), hematocrit (hCT), and platelets (PLT) decreased. During the dive, concentrations of creatine kinase (CK), a myocardial-specific isoenzyme of creatine kinase (CK-MB) in serum and amylase alpha 1 (AMY1), and testosterone levels in saliva increased, in contrast, IgA levels in saliva decreased. Diving caused a significant increase in serum glutathione (GSH) levels and reduced vascular cell adhesion molecule-1 (VCAM-1) levels but had no effect on malondialdehyde (MDA) and endothelin-1 (ET-1) levels.Conclusion: A single 80 msw heliox dive activates the endothelium, causes skeletal-muscle damage, and induces oxidative stress and physiological stress responses, as reflected in changes in biomarker concentrations.
COVID-19: Pulmonary and Extra Pulmonary Manifestations
Authors: Elrobaa Islam H. , New Karl J. 
Published: September 2021

Introduction: The coronavirus disease-2019 (COVID-19) pandemic has been the most significant event in 2020, with ~86.8 million cases and 1.88 million deaths worldwide. It is a highly infectious disease, wherein the virus (severe acute respiratory syndrome coronavirus 2) rapidly multiplies and spreads to all parts of the body. Therefore, COVID-19 is not only respiratory disease but also a multisystem disease. Many people, including physicians, incorrectly believe that the disease affects only the respiratory tract. In this study, we aimed to describe COVID-19 manifestations and the underlying pathophysiology to provide the readers with a better understanding of this disease to achieve good management and to control the spread of this disease.Methods: Secondary data were obtained from PubMed, Google Scholar, and Scopus databases. The keywords used for the search were as follows: COVID-19, COVID-19 pulmonary manifestations, COVID-19 extra pulmonary manifestations, and pathophysiology of COVID-19. We collected secondary data from systemic reviews, metaanalyses, case series, and case reports in the form of public data that was published on websites of the government, medical corporations, medical peer-reviewed journals, and medical academies, all of which were indexed in PubMed, Google Scholar, or Scopus. Our questions were as follows: Is COVID-19 a respiratory disease only? and What are the extrapulmonary manifestations of COVID-19?Results: From our data, we found that a patient with COVID-19 may be either asymptomatic or symptomatic. Symptomatic cases may have either pulmonary or extrapulmonary manifestations. Pulmonary manifestations occur as mild, moderate, or severe cases. In mild and moderate cases, extrapulmonary manifestations such as gastroenteritis, fever, or vomiting may present alone. Some of these cases may be missed for diagnosis, and the patient may receive symptomatic treatment without a COVID-19 diagnosis, leading to increased spread of the infection. Extrapulmonary manifestations may occur in severe and critical cases as complications of severe infections (high viral overload) or the cytokine storm, such as in acute kidney injury (AKI), heart failure (HF), and venous thromboembolic (VTE) manifestation.Conclusion: COVID-19 is not a respiratory disease alone; rather, it is a multisystem disease. Pulmonary and extrapulmonary manifestations should be considered for early diagnosis and to control the spread of the infection.
Late Radiation–Related Toxicities in Patients Treated for Early-Stage Cervical Carcinoma by Surgery and Adjuvant Radiotherapy: A Retrospective Imaging Study
Authors: Nadova Katarina , Burghardtova Miroslava , Fejfarova Klara , Reginacova Klaudia , Malikova Hana 
Published: September 2021

Surgical treatment is preferred therapy of early-stage cervical carcinoma. In the risk of cancer recurrence surgery is often followed by adjuvant radiotherapy. In our retrospective study we aimed at identifying late (≥6 months) and very late (≥5 years) radiation adverse effects on imaging scans as CT, PET/CT and MRI in patients who underwent successful treatment for cervical carcinoma by radical surgery combined with radiotherapy ± chemotherapy. We correlated imaging results with clinical manifestations. We selected young and middle-aged patients with long life expectancy, as late radiation-related toxicities may significantly affect their quality of life. Patients were selected from those who were primary diagnosed and treated between the years 1987–2011 and regularly visited our Oncology department in years 2011–2012. Following inclusion criteria were applied: age ≤55 years at diagnosis, clinical follow-up ≥5 years and at least one tomography scan ≥3 years after finished treatment. One hundred and three subjects were reviewed: 73 patients met all inclusion criteria, while 30 patients fulfilled the inclusion criteria except for available tomography scan ≥3 years after therapy. The mean imaging follow-up was 11.2 ± 7.6 years and the mean clinical follow-up was 15.0 ± 6.9 years. In 20 (27%) subjects 27 cases grade I radiation-related toxicities were found; 9 (33%) of those 27 cases were clinically silent. In 14 (19%) females only grade I toxicities were observed. Grade III-IV toxicities were found in 5 (6.8%) subjects. No grade V toxicities were observed. We concluded that severe late side effects caused by radiotherapy were exceedingly rare in females successfully treated for early-stage cervical carcinoma, only 1 bilateral osteonecrosis, 2 cases of ileus, and 2 potentially radiation-induced tumors were found. The majority of radiation-related comorbidities found on imaging scans were clinically silent.
SOME ASPECTS OF IMPORT SUBSTITUTION IN THE DOMESTIC SOFTWARE DEVELOPMENT FOR THE DESIGN OF ANTENNA-FEEDER DEVICES
Authors: НИКОЛАЕВА В.Я. , ЛУЧИН Д.В. , ТРОФИМОВ А.П. , ФИЛИППОВ Д.В. , ЮДИН В.В. 
Published: September 2021

Рассматриваются вопросы импортозамещения при создании отечественного программного обеспечения для проектирования антенно-фидерных устройств. Обозначены основные аспекты проблемы: импортозамещение при создании вычислительных ядер (решение электродинамических задач,задач анализа цепей СВЧ,расчет антенных характеристик и т.д.)и импортозамещение при создании пользовательских интерфейсов и средств электродинамического моделирования. Дается оценка состояния вопроса в отечественной теории и практике в указанных областях. С общих позиций анализируется круг задач, требующих решения для обеспечения процессов импортозамещения. Оцениваются возможности и перспективы реализации данных процессов на практике.
The problems of import substitution in the domestic software development for the design of antenna-feeder devices are considered. The main aspects of the import substitution problem are outlined: calculation kernel design (electrodynamic simulation problem, RF-circuit analysis problem, antenna performance definition problem, etc.), user interface design, and electrodynamic modeling tools. The assessment of the state in the domestic theory and practice in these areas is given. From a general point of view, the authors analyze the range of tasks that need to be solved to ensure import substitution processes. The possibilities and prospects for the implementation of these processes in practice are evaluated.
APPLICATION OF THE HILBERT TRANSFORMER FOR SHAPING POLARIZATION-SEPARATED RADIO WAVES OF THE HIGH-FREQUENCY RANGE
Authors: БАРАБОШИН А.Ю. , ЛУЧИН Д.В. , МАСЛОВ Е.Н. 
Published: September 2021

Рассматривается способ формирования поляризационно-разнесенных радиоволн ДКМВ-диапазона при организации системы MIMO2^2 с использованием компактных турникетных антенн. Приведены результаты оценки эффективности применения поляризационного разнесения, а также сравнительной производительности и помехоустойчивости предложенного и иных способов организации подобных систем. Показаны преимущества использования разработанного технического решения.
A method for the formation of polarization-separated HF radio waves in the MIMO2x2 system using compact turnstile antennas is considered. The results of evaluating the effectiveness of the use of polarization diversity, as well as the comparative performance and noise immunity of the proposed and other methods of organizing such systems are presented. The advantages of applying the developed technical solution are shown.
Sistem Pendukung Keputusan Penerima Bantuan Pandemi Menggunakan Metode AHP (Analytical Hierarchy Process)
Authors: Lumbantoruan Sister P 
Published: September 2021

Pandemi Covid-19 telah ditetapkan sebagai pandemi global oleh Organisasi Kesehatan Dunia (WHO). Dampak pandemi yang terjadi terhadap perekonomian Indonesia mendorong pemerintah untuk memberikan perhatian besar terhadap masyarakat di lapisan bawah dengan mengadakan program bantuan. Adanya simpang siur mengenai ketidak tepat sasaran bantuan tersebut sehingga peneliti memikirkan untuk menggangkat judul Sistem Pendukung Keputusan Penentuan Penerima Bantuan Pandemi Menggunakan Metode AHP (Analytical Hierarchy Process) sehingga penerima bantuan dapat ditentukan berdasarkan kriteria- kriteria yang ditetapkan menggunakan sistem yang diterapkan dengan metode AHP (Analytical Hierarchy Process). Hasil yang diperoleh dalam penelitian ini adalah penerapan metode AHP dimana setiap kriteria dan alternatif dinilai berdasarkan tingkat kepentingan masing- masing dan dilakukan perbandingan berpasangan setiap kriteria dan alternatif sehingga diperoleh bobot masing- masing kriteria dan alternatif. Berdasarkan bobot tersebut dari 5 alternatif kepala keluarga calon penerima bantuan 3 kepala keluarga dinyatakan layak menerima bantuan.
Kata Kunci: Bantuan, Pandemi, AHP.
Pandemi Covid-19 telah ditetapkan sebagai pandemi global oleh Organisasi Kesehatan Dunia (WHO). Dampak pandemi yang terjadi terhadap perekonomian Indonesia mendorong pemerintah untuk memberikan perhatian besar terhadap masyarakat di lapisan bawah dengan mengadakan program bantuan. Adanya simpang siur mengenai ketidak tepat sasaran bantuan tersebut sehingga peneliti memikirkan untuk menggangkat judul Sistem Pendukung Keputusan Penentuan Penerima Bantuan Pandemi Menggunakan Metode AHP (Analytical Hierarchy Process) sehingga penerima bantuan dapat ditentukan berdasarkan kriteria- kriteria yang ditetapkan menggunakan sistem yang diterapkan dengan metode AHP (Analytical Hierarchy Process). Hasil yang diperoleh dalam penelitian ini adalah penerapan metode AHP dimana setiap kriteria dan alternatif dinilai berdasarkan tingkat kepentingan masing- masing dan dilakukan perbandingan berpasangan setiap kriteria dan alternatif sehingga diperoleh bobot masing- masing kriteria dan alternatif. Berdasarkan bobot tersebut dari 5 alternatif kepala keluarga calon penerima bantuan 3 kepala keluarga dinyatakan layak menerima bantuan.
The Role of Binary Settings in John Updike’s Short Stories: A Structuralist Approach
Authors: Al-Jamani Muayad Enwiya Jajo 
Published: September 2021

John Updike’s use of setting in his fiction has elicited different and even conflicting reactions from critics, varying from symbolic interpretations of setting to a sense of confusion at his use of time and place in his stories. The present study is an attempt at examining John Updike’s treatment of binary settings in Pigeon Feathers and Other Stories (1962) to reveal theme, characters’ motives and conflicts. Analyzing Updike’s stories from a structuralist’s perspective reveals his employment of two different places and times in the individual stories as a means of reflecting the psychological state of the characters, as in “The Persistence of Desire”, or expressing conflicting views on social and political issues, as in “A&P” and “Home”, or commenting on religious issues as in “Pigeon Feathers.” The study also examines Updike’s use of setting as a structural device to provide unity to the diverse stories in the collection. The study concludes that binary settings provide structural unity to the stories in the collection and add a psychological dimension and depth to the characters.
ASPECTOS CULTURAIS E METODOLÓGICOS NO PROCESSO DE APRENDIZAGEM DOS ESTUDANTES INDÍGENAS MACUXI: EXPERIÊNCIAS DO INSTITUTO FEDERAL DE RORAIMA CAMPUS AMAJARI
Authors: Silva Maria Aparecida Xavier , Felzke Lediane Fani 
Published: September 2021

O presente artigo tem como objetivo compreender aspectos sobre como os indígenas constroem o conhecimento e dialogam os saberes indígenas e não indígenas no processo de ensino-aprendizagem na Educação Profissional e Tecnológica. Para isso, foi desenvolvida uma pesquisa participante que contou com o envolvimento de 21 estudantes indígenas da etnia Macuxi que estavam cursando o terceiro ano do curso Técnico em Agropecuária Integrado ao Ensino Médio em Regime de Alternância do Instituto Federal de Roraima/Campus Amajari. O estudo revelou que o processo de ensino e aprendizagem torna-se mais significativo quando os docentes buscam aproximar as disciplinas, ofertadas pelo curso, dos saberes tradicionais dos estudantes indígenas. Contudo os estudantes argumentam que são poucos os professores que têm essa preocupação de contextualizar os conteúdos ensinados com a vivência do dia a dia. Com isso, conclui-se, que o Campus precisa possibilitar estratégias que valorizem os saberes prévios dos estudantes no ensino de novos conteúdos ofertados durante o curso.
Pemberdayaan Ibu Pasca Bersalin, Keluarga, tentang PHBS, Perawatan Ibu dan Bayi serta Pencegahan Penularan COVID-19
Authors: Wahyuni Islah , Hasanah Ulfa , Yanti Novi , Putra Ifon Driposwana 
Published: September 2021

Covid-19 pandemic is determined as non-natural disaster, because its rapid transmission and endanger humans, especially pregnant women, childbirth, post-partum, newborns. The increase ofincidence number that befall the community from day to day, there are still families and postpartum mothers who do not understand in postnatal maternal and infant health care and prevention of covid transmission 19. to increase family participation and knowledge of postpartum mothers about maternal and infant health care in the prevention of Covid-19 transmission and its application during the first week of her baby's birth at home. This coaching was implementating from April to June 2020 on 20 post partum mothers while being treated at the midwife clinic and during homecare services in the first week, by providing education, fill post-test questionnaire, observing the implementation of maternal and infants careand Covid 19 prevention at home. Family participation increased by 16 people (80%), Post-Test Knowledge was good for 17 people (85%), Good Mother and Baby Care Techniques for 13 people (65%). It is hoped that postpartum motherswill continue to carry out maternal and infant care and prevention of Covid 19 during the pandemic period as suggested by the midwife.
CARL’S SURVIVAL MOTIVATION IN UP MOVIE
Authors: Owa Maxima , Separ Fransiskus Maria , Wanggai Febe F. Irawati 
Published: September 2021

Penelitian ini bertujuan untuk menemukan jenis-jenis motivasi dan cara untuk bertahan hidup dalam film Up. Dalam penelitian ini, metode deskriptif kualitatif digunakan untuk menggambarkan ucapan dan tindakan dari tokoh. Pendekatan psikologis diterapkan untuk menganalisis jenis-jenis motivasi dan cara untuk bertahan hidup. Teori yang digunakan untuk menganalisis jenis-jenis motivasi adalah teori yang diusulkan oleh Runyon (1984), sedangkan untuk menganalisis cara untuk bertahan hidup, teori yang diusulkan oleh McClleand (1987) yang dipakai. Hasil penelitian menunjukkan bahwa ada empat jenis motivasi yaitu motivasi intrinsik, motivasi ekstrinsik, motivasi kontributif, dan motivasi relasional. Sedangkan cara untuk bertahan hidup di film Up, yaitu kebutuhan akan prestasi, kebutuhan akan afilisasi, dan kebutuhan akan kekuatan
LIVE-streaming 3D images: A neuroscience approach to full-body illusions
Authors: de Boer D. M. L. , Namdar F. , Lambers M. , Cleeremans A. 
Published: September 2021

AbstractInspired by recent technological advances in the gaming industry, we used capture cards to create and LIVE-stream high quality 3D-images. With this novel technique, we developed a real-life stereoscopic 3D full-body illusion paradigm (3D projection). Unlike previous versions of the full-body illusion that rely upon unwieldy head-mounted displays, this paradigm enables the unobstructed investigation of such illusions with neuroscience methods (e.g., transcranial direct current stimulation, transcranial magnetic stimulation, electroencephalography, and near-infrared spectroscopy) and examination of their neural underpinnings. This paper has three aims: (i) to provide a step-by-step guide on how to implement 3D LIVE-streaming, (ii) to explain how this can be used to create a full-body illusion paradigm; and (iii) to present evidence that documents the effectiveness of our methods (de Boer et al., 2020), including suggestions for potential applications. Particularly significant is the fact that 3D LIVE-streaming is not GPU-intensive and can easily be applied to any device or screen that can display 3D images (e.g., TV, tablet, mobile phone). Therefore, these methods also have potential future clinical and commercial benefits. 3D LIVE-streaming could be used to enhance future clinical observations or educational tools, or potentially guide medical interventions with real-time high-quality 3D images. Alternatively, our methods can be used in future rehabilitation programs to aid recovery from nervous system injury (e.g., spinal cord injury, brain damage, limb loss) or in therapies aimed at alleviating psychosis symptoms. Finally, 3D LIVE-streaming could set a new standard for immersive online gaming as well as augmenting online and mobile experiences (e.g., video chat, social sharing/events).
Enchantment and non-human voices in the Sámi yoik
Authors: Aubinet Stéphane 
Published: September 2021

The yoik is a vocal technique used by the Sámi people in the northernmost part of Europe. It consists in short circular melodies chanted a cappella and intended to make a person, an animal, or a place present. In the view of many “yoikers,” it is a gift received from the environment that you learn through participation and experimentation. This paper uses the concept “enchantment” as a conceptual bias to comment on two encounters: an anecdote about a yoiker who managed to frighten a couple of elk by chanting the bear’s melody and a Sámi poem about the yoiking wind. These encounters address, in turn, the way humans can yoik to animals and the way non‑humans can yoik to humans, displaying in both cases how chants may affect the perception of a place.
Clinical Characteristics and Risk Factors of Liver Dysfunction in COVID-19 Patients
Authors: Jiang Xiaofang , Zhang Jiahao , Yang Cheng , Xie Qin , Xiao Guanfa , Wang Fengqin , Shen Sanying , Su Lianjiu , Peng Zhiyong 
Published: September 2021

Abstract

Background:
COVID-19 outbreak has spread around the world. Liver dysfunction (LD) was related with high mortality in COVID-19.

Methods:
Retrospective, single-center study case series of 425 consecutive hospitalized COVID-19 patients were enrolled. Demographic, clinical, laboratory, and treatment data were collected.

Results:
A total of 425 patients were included in this study, 145 of whom had LD. The overall mortality rate was 8.9%, while 17.9% in the LD group and 4.3% in the nonliver dysfunction (NLD) group. Age, sex, and hypertension were the independent risk factors of LD. LD was an independent risk factor for incidence of severe illness, acute respiratory distress syndrome, and death. The survival rate of patients in LD group was lower than that in NLD group (P < 0.001). A similar trend was observed by the multivariate regression analysis (adjusted hazard ratio, 3.52; 95% confidence interval [CI], 1.69-7.33; P = 0.001). Angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers had effect to reduce LD (odds ratio of 0.48 [95% CI, 0.232-0.989; P = 0.045]).

Conclusions:
LD is one of the main features of hospitalized patients of COVID-19, with a worse prognosis. Patients of COVID-19 with LD on admission should be more cautions.