bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro‐Angiogenic Macrophage Polarization via Activation of the PI3K‐Akt Signaling Pathway
Authors: Cui Qun , Zheng Xiaona , Bai Yunyang , Guo Yaru , Liu Shuo , Lu Yanhui , Liu Lulu , Song Jia , Liu Yang , Heng Boon Chin , You Fuping , Xu Mingming , Deng Xuliang , Zhang Xuehui 
Published: December 2024

AbstractRegulation of the immune response is key to promoting bone regeneration by electroactive biomaterials. However, how electrical signals at the micro‐ and nanoscale regulate the immune response and subsequent angiogenesis during bone regeneration remains to be elucidated. Here, the distinctly different surface potential distributions on charged poly(vinylidene fluoridetrifluoroethylene) (P(VDF‐TrFE)) matrix surfaces are established by altering the dimensions of ferroelectric nanofillers from 0D BaTiO3 nanoparticles (homogeneous surface potential distribution, HOPD) to 1D BaTiO3 nanofibers (heterogeneous surface potential distribution, HEPD). Compared to HOPD, HEPD is significantly better at inducing the M2 polarization of macrophages and promoting neovascularization, which results in accelerated bone regeneration in vivo. The transcriptomic analysis reveals that macrophages modulated by HEPD display high expression levels of pro‐angiogenic genes, which is corroborated by tube‐formation assays, RT‐qPCR, and western blot analyses in vitro. Mechanistic explorations elucidate activation of the PI3K‐Akt signaling pathway, which in turn induces the polarization of macrophages toward a pro‐angiogenic phenotype. This study elucidates the cascade of biological processes by which heterogeneous electrical signals at the micro‐ and nanoscale modulate macrophage functions to promote vascularization and bone regeneration. Hence, this study provides new insights into how the micro‐ and nanoscale distribution characteristics of electrical signals facilitate bone regeneration.
Interfacial Engineering of Metal Chalcogenides‐based Heterostructures for Advanced Sodium‐Ion Batteries
Authors: Zhang Yuxiang , Han Bo , Tan Shuangshuang , Gao Qiang , Cai Zhao , Zhou Chenggang , Li Jiantao , Sun Ruimin , Amine Khalil 
Published: December 2024

AbstractSodium‐ion batteries (SIBs) have become one of the most promising candidates for large‐scale energy storage applications. Metal chalcogenides anode materials based on alloying or conversion reactions are widely studied because of their high theoretical capacities and rich redox reactions. However, their intrinsic limitations such as high voltage hysteresis and large volume expansion hinder their further applications. The construction of heterostructures has become an attractive strategy to alleviate the above issues. The formation of built in electric fields (BIEFs) at the heterointerfaces will accelerate the migration of Na+ and electrons. Moreover, heterostructures can also enhance the structural stability, generate more active sites and provide additional capacity. It is worth noting that heterointerfacial properties play a significant role in promoting the overall electrochemical performance of the heterostructures. However, a systematic understanding of their interfacial engineering is currently lacking. This article reviews the research progress of metal chalcogenides‐based heterostructure anode materials in the near term. First, the definition, classification and the roles of heterostructures are introduced. Second, the detailed research progress of the metal chalcogenide‐based heterostructures anodes in SIBs is discussed. Finally, the future prospects and potential research directions of the heterostructures for batteries are discussed.
Laligurans (Rhododendron arboreum) Enhances Growth, Enzyme Profiles, and Immune Response of Grass Carp Ctenopharyngodon idella (Val. 1844)
Authors: Jha Anil Kumar , Khalid Monowar Alam , Labh Shyam Narayan 
Published: December 2024

ABSTRACTThis study evaluates the effects of Laligurans (Rhododendron arboreum) flowers on the growth performance and health parameters of grass carp (Ctenopharyngodon idella). Known for their anti‐inflammatory properties and medicinal uses, Laligurans flowers were incorporated into diets as an ethanol extract (LGE) and fine powder (LGP) to test their efficacy. A total of 630 grass carp fingerlings (3.07 ± 0.76 g to 3.95 ± 0.85 g) were randomly distributed into 21 nylon cages (1.5 m × 1 m × 2 m) placed in an earthen pond. Seven dietary treatments were administered: a control diet (T1) with standard commercial feed, LGE‐supplemented diets (T2, T3, T4, and T5) at 0.20%, 0.40%, 0.80%, and 1.60% inclusion levels, respectively, and LGP‐supplemented diets (T6 and T7) at 0.20% and 0.40%, respectively. Results demonstrated significant improvements (p < 0.05) in liver, kidney, and blood serum protein levels (total protein, albumin, globulin, and AG ratios) in treated groups compared to the control. Reductions in SGOT, SGPT, and ALP levels were observed in the liver and blood serum of treated groups, while control fish exhibited elevated blood urea nitrogen and creatinine. Fish fed LGE diets showed superior blood profiles compared to those receiving LGP. The T4 group (0.80% LGE) achieved the highest final weight gain, specific growth rate, and survival rate (p < 0.05), highlighting the potential of Laligurans flower extract as a natural immunological and growth‐enhancing supplement in aquaculture diets.
Evaluation of oxygenated and ozonated nanobubble water treatments for dollar spot suppression in seashore paspalum
Authors: Spratling Willis T. , Jespersen David , Waltz Clint , Martinez‐Espinoza Alfredo D. , Bahri Bochra A. 
Published: December 2024

AbstractDollar spot (caused by Clarireedia spp.) is the most commonly occurring turfgrass disease on golf courses in North America, and current disease control programs rely on frequent fungicide applications. The escalating occurrence of fungicide resistance in Clarireedia spp. populations, coupled with the reduction of the annual kilograms active ingredient applied per hectare for some fungicides, emphasizes the need for alternative management strategies. The use of oxygenated or ozonated water treatments has been effective as a component of an overall plant disease management strategy. In field and growth chamber‐controlled environment trials, the impacts of oxygenated and ozonated nanobubble water treatments were evaluated for turf quality and dollar spot control in seashore paspalum (Paspalum vaginatum Swartz). Despite generating relatively high levels of dissolved oxygen (40 mg L−1) or ozone (ca. 8 mg L−1) in water treatments through nanobubble aeration in all trials, these treatments did not cause damage to seashore paspalum tissues, but were unsuccessful in controlling dollar spot. Additionally, tests comparing two different application methods (soil drench versus foliar spray) for all treatments suggested that the application method had no effect on treatment efficacy. Overall, oxygenated and ozonated nanobubble water treatments did not adversely affect seashore paspalum turf quality and were ineffective in suppressing dollar spot in field and growth chamber trials.
Cotton stalk management and a cover crop produce minimal effects on cotton leafroll dwarf virus
Authors: Frazier Samuel , Brown Steven M. , Read Quentin D. , Jacobson Alana L. , Conner Kassie , Escalante Cesar , Balkcom Kipling S. 
Published: December 2024

AbstractIn 2017, cotton (Gossypium hirsutum L.) leafroll dwarf virus (CLRDV) was first reported in the United States. One CLRDV inoculum source includes the previous year's cotton stalks; hence, destroying cotton stalks could be effective for CLRDV management. However, tillage‐intensive stalk destruction methods (SDMs) can degrade southeastern soils, but a cover crop may provide short‐term benefits and reduce CLRDV incidence. Therefore, we examined three SDMs (Tillage, Pull, Mow) across two cover crop levels (no cover and rye [Secale cereale L.]/clover [Trifolium incarnatum L.] mixture) and two cotton varieties to determine how cotton growth, soil penetration resistance (PR), and two CLRDV incidence sample times (pre‐harvest and post‐harvest) were affected across six environments during the 2021 and 2022 growing seasons. None of the SDMs affected any factors examined in this experiment, except soil PR and cotton yield. The Pull and Mow SDMs both increased soil PR compared to the Tillage SDM. An 8% yield increase (Pull > Mow) was observed, but the Tillage SDM yield did not differ from Pull or Mow SDMs. The rye/clover mixture also increased soil PR. Although cotton stands were 15% greater with no cover crop, subsequent cotton yield and fiber quality were minimally affected by cover crops. The rye/clover mixture increased post‐harvest CLRDV incidence, and cotton yields were equal between cover crops. Pre‐harvest CLRDV incidence probability was 0.23, but post‐harvest CLRDV incidence probability was 0.71. Continuing to identify and evaluate cultural practices that reduce CLRDV incidence is imperative to prevent negative impacts.
Type 2 biomarkers in olfactory cleft mucus correlate with SNOT‐22 in chronic rhinosinusitis independent of nasal polyp status
Authors: Chapurin Nikita , Soler Zachary M. , Khan Sofia , Mulligan Jennifer K. , Ramakrishnan Vijay R. , Mace Jess C. , Smith Timothy L. , Alt Jeremiah A. , Mattos Jose L. , Rathi Vinay K. , Schlosser Rodney J. 
Published: December 2024

AbstractBackgroundQuantitative mucus cytokine analysis to examine the sinonasal microenvironment may bridge the gap between patient‐reported outcome measures (PROMs) and empirical measures of inflammation in patients with chronic rhinosinusitis (CRS).ObjectiveInvestigate the correlation between mucus cytokine levels and Sino‐Nasal Outcome Test (SNOT‐22) scores, including individual subdomains.MethodsPatients with CRS were prospectively recruited between 2016 and 2021 into a multi‐institutional observational study. Mucus was collected from the olfactory cleft and evaluated for mucus cytokine biomarkers. Spearman correlations (ρ) between cytokine levels and SNOT‐22 scores, including individual subdomains, Lund–Mackay (LM) CT and Lund–Kennedy (LK) endoscopy scores were assessed. Subgroup analysis based on nasal polyp status (CRSsNP—without nasal polyps; CRSwNP—with nasal polyps) was also performed. Linear regression was employed to identify multivariate associations between cytokine expression levels, clinical covariates, and SNOT‐22 total and domain scores.ResultsA total of 127 patients were included in the study (CRSsNP = 53, CRSwNP = 74). IL‐9 (ρ = 0.196, p < 0.05) was the only biomarker that correlated with the SNOT‐22 total score. CRSwNP patients had a higher absolute expression level of Type 2 biomarkers (IgE, IL‐5, and IL‐13), compared to CRSsNP patients. IgE, IL‐5, IL‐9, and IL‐13 significantly correlated with the SNOT‐22 rhinologic subdomain scores (p < 0.001), LM scores, and patient reported sense of smell (Question 21). Notably, subgroup analysis showed that CRSsNP patients also demonstrated significant correlations between Type 2 markers (IL‐4, IL‐5, IL‐9, and IL‐13) and SNOT‐22 rhinologic subdomain scores.ConclusionType 2 mucus cytokine levels, especially IL‐9, correlate with SNOT‐22, and the rhinologic SNOT‐22 subdomain scores for both CRSsNP and CRSwNP patients.
Applying recommendations for diagnostic disclosure of mild cognitive impairment and dementia: Practical guidance for clinicians
Authors: O'Brien Kyra , Largent Emily A. , Karlawish Jason 
Published: December 2024

AbstractA comprehensive evaluation for cognitive impairment should culminate with the communication of the diagnosis to patients and their care partners. This diagnostic disclosure sets the stage for subsequent care. Diagnostic disclosure for individuals with cognitive impairment due to Alzheimer's disease (AD) or AD‐related dementias (ADRD) is particularly nuanced and requires a conscientious approach. Clinicians must assess patients’ understanding and appreciation of symptoms, goals for the evaluation, and desire for information. Because AD/ADRD can impact patients’ perceptions of their symptoms, it is recommended to include an informant or care partner for this assessment and for future care. Here, we provide guidance for addressing the complexities of AD/ADRD diagnostic disclosure to build clinicians’ confidence in communicating diagnostic findings and a plan of care.Highlights
Diagnostic disclosure is a key part of the evaluation of cognitive impairment.
The disclosure process begins at the moment a cognitive evaluation is initiated.
Care partners must be included in the cognitive evaluation and diagnostic disclosure.
Clinicians should use patient‐centered communication for evaluation and disclosure.
Rapid Na+ Transport Pathway and Stable Interface Design Enabling Ultralong Life Solid‐State Sodium Metal Batteries
Authors: Su Chang , Qu Yunpeng , Hu Naiwen , Wang Lin , Song Zihui , Pei Mengfan , Mao Runyue , Jin Xin , Liu Dongming , Jian Xigao , Hu Fangyuan 
Published: December 2024

AbstractSodium‐metal batteries (SMBs) using solid‐state polymer electrolytes (SPEs) show impressive superiority in energy density and safety. As promising candidates for SPEs, solid‐state plastic crystal electrolytes (SPCE) based on succinonitrile (SN) plastic crystal could achieve high ion conductivity and wide voltage window. Nonetheless, the notorious SN decomposition reaction on the electrode/electrolyte interface seriously challenges the stable operation of the battery. To address this drawback, we commence with the structural engineering of the polymer chain segments in SPCE and employ intermolecular interactions to optimize the composition of solid electrolyte interface (SEI). Moreover, this study emphasizes the importance of polymer network design in optimizing the migration behavior of sodium ions in SPCE. The assembled sodium symmetric cells display a high critical current density of up to 2.7 mA cm−2 and stable cycling performance for 700 hours at 0.5 mA cm−2. Furthermore, the Na/SPCE‐9/Na3V2(PO4)3 maintains a discharge specific capacity of up to 76.8 mAh g−1 at 10 C and shows impressive long‐cycle stability, retaining 86.2 % of initial capacity over 5000 cycles with an average coulombic efficiency of 99.9 %. Our work presents a high‐performance SPCE with intrinsic safety, providing valuable insights for the future design of solid‐state SMBs.
Phänomik‐basierte Entdeckung neuer orthosterischer Cholinkinase Inhibitoren
Authors: Bauer Ludwig G. , Ward Jennifer A. , Díaz‐Sáez Laura , Sundström Yvonne , Tolvanen Tuomas , Alarcón Barrera Juan Carlos , Kostidis Sarantos , Rogers Catherine M. , Panagakou Ioanna , Singh Usha , Rothweiler Elisabeth M. , Gonzalez Orta Alejandro , Kaniskan H. Ümit , Hu Jianping , Jin Jian , Sievers Sonja , Waldmann Herbert , Giera Martin , Sundström Michael , Berg Louise , Huber Kilian V. M. 
Published: December 2024

AbstractCholinkinase alpha (CHKA) ist ein zentraler Signalgeber innerhalb des Zellstoffwechsels, der mit Krebs und der Immunregulation in Verbindung gebracht wird. Die zelluläre und klinische Bewertung von CHKA als Zielstruktur für Wirkstoffe wurde bisher durch Herausforderungen bei der Entwicklung von arzneimittelähnlichen Cholinkinasehemmstoffen behindert. In der vorliegenden Studie zeigen wir mihilfe eines integrierten phänomischen Ansatzes, dass CHKA ein unerwartetes Off‐Target von Histonmethyltransferasehemmstoffen ist. Wir identifizieren CHKA als direkte Proteinzielstruktur der Aminochinazoline UNC0638 und UNC0737 durch eine Kombination von chemoproteomischen, biochemischen, zellulären und metabolischen Analysen. Diese Entdeckung erklärt möglicherweise die zuvor berichteten Diskrepanzen, die für unterschiedliche G9a/GLP‐Hemmstoffgerüste in zellulären Versuchen beobachtet wurden. Unter Verwendung von primären menschlichen Zellmodellsystemen weisen wir nach, dass die pharmakologische Beeinflussung von CHKA die IgG‐Freisetzung und die B‐Zell‐Reifung beeinträchtigt, im Einklang mit der These, dass der Cholin‐Stoffwechsel eine wichtige Rolle bei der Signalgebung des Immunsystems spielt. Die Kristallstrukturen von UNC0638 und UNC0737 im Komplex mit CHKA offenbaren einen unerwarteten Bindungsmodus und deuten darauf hin, dass diese Hemmstoffe als attraktive Ausgangspunkte für die Entwicklung selektiver chemischer Sonden zur weiteren Erforschung der biologischen Rolle von CHKA im Krebs‐ und Immunstoffwechsel genutzt werden können.
La3+ Doped Nickel‐Manganese Oxide as High‐Capacity Cathode for Sodium‐Ion Batteries Guided by Bayesian Optimization
Authors: Feng Jie , Liu Dapeng , Sun Jin , Gong Xiangrui , You Tingting , Jiang Ying , Zhang Yu 
Published: December 2024

AbstractIn sodium‐ion batteries, the layered transition metal oxides used as cathode often experience interlayer sliding of interlayer spacing and lattice variations during charge/discharge, leading to structural damage and capacity degradation. To address this challenge, a La3+ doping strategy guided by Bayesian optimization has been employed to prepare the high‐performance O3‐NaNi0.39Mn0.50Cu0.06La0.05O2 (NMCL) cathode material. Density functional theory calculations reveal that the O 2p orbital overlaps with the t2g orbital of transition metals in NMCL, facilitating the formation of Na−O−La bonds and promoting the oxygen redox reaction kinetics. During the Na+ (de)intercalation process, NMCL exhibits significant negative lattice expansion, characterized by an increase in the c lattice parameter and exceptionally low volume expansion of 1.8 % and 3.1 %, respectively. Consequently, it delivers an excellent specific capacity of 243.3 mAh g−1 over a wide voltage range of 2.0 V to 4.5 V, which can be attributed to La3+ doping that promotes oxidation of O2− to peroxide O2n− (n<2) during charge.
Cascade Selenization Regulated the Electronic Structure and Interface Effect of Transition Metal Sulfides for Enhanced Sodium Storage
Authors: Feng Ting , Wang Fang , Sun Zixu , Guo Fangya , Xiong Yi , Ren Fengzhang , Tang Chunjuan , Li Jili , Kun Liu Hua , Xue Dou Shi 
Published: December 2024

AbstractThe utilization of cobalt‐based sulfides is constrained by their inherently low conductivity and slow sodium ion diffusion kinetics. Modifying the electronic configuration and constructing heterostructures are promising strategies to enhance intrinsic conductivity and expedite the sodium ion diffusion process. In this study, heterogeneous nanoparticles of Se‐substituted CoS2/CoSe2, embedded within heteroatom‐modified carbon nanosheet, were synthesized using metal molten salt‐assisted dimensionality reduction alongside concurrent sulfurization and selenization techniques. The incorporation of Se into CoS2 markedly enhances its intrinsic conductivity, thereby significantly improving its rate performance. The elongated Co−S bonds and the formation of CoSe2 species contribute to the acceleration of dynamics and facilitate the construction of the CoS2/CoSe2 heterointerface. In situ Raman spectroscopy, in conjunction with theoretical calculations, has elucidated the sodium storage mechanism of the Se−CoS2/CoSe2 and the underlying factors contributing to its enhanced performance. The synergistic effects of interface engineering and electronic structure engineering, have resulted in the optimized Se−CoS2/CoSe2 demonstrating exceptional rate performance, achieving 442 mAh g−1 at 10 A g−1, and a prolonged cycle lifespan, maintaining 409.3 mAh g−1 at 5 A g−1 over 2100 cycles and 262.5 mAh g−1 after 7000 cycles at 10 A g−1. This study presents a viable strategy for integrating electronic structure engineering with interface engineering.
In‐Situ Cross‐Linked Polymers for Enhanced Thermal Cycling Stability in Flexible Perovskite Solar Cells
Authors: Li Zhihao , Jia Chunmei , Wu Hongzhuo , Tang Ying , Zhao Jinbo , Su Zhenhuang , Gao Xingyu , Qiu Shuai , Yuan Hongxing , Li Meng 
Published: December 2024

AbstractFlexible perovskite solar cells (FPSCs) are a promising emerging photovoltaic technology, with certified power conversion efficiencies reaching 24.9 %. However, the frequent occurrence of grain fractures and interface delamination raises concerns about their ability to endure the mechanical stresses caused by temperature fluctuations. In this study, we employ an in situ polymerization molecule with extended functional end groups to preserve mechanical integrity during thermal cycling. The AMPS‐DEA molecule chemically anchors to grain boundaries and cross‐links neighboring grains, protecting the structure from stress accumulation. Additionally, its hydroxyl groups form bidentate chelation with SnO2, enhancing interfacial adhesion and preventing delamination. More importantly, the relaxed residual stress provided by AMPS‐DEA allows the perovskite layer to adapt to temperature changes, effectively matching adjacent layers and preventing mechanical failure. Our findings demonstrate that AMPS‐DEA modification not only boosts PCE to 25.78 % in rigid PSCs and 24.54 % in flexible PSCs but also improves stability, maintaining over 95 % efficiency after 10,000 bending cycles and 200 thermal cycles.
A Bifunctional Imidazolyl Iodide Mediator of Electrolyte Boosts Cathode Kinetics and Anode Stability Towards Low Overpotential and Long‐Life Li‐O2 Batteries
Authors: Liu Jing , Li Yuejiao , Ding Yajun , Wu Lisha , Qin Jieqiong , Chen Tongle , Meng Caixia , Zhou Feng , Ma Xiangkun , Wu Zhong‐Shuai 
Published: December 2024

AbstractThe addition of a redox mediator as soluble catalyst into electrolyte can effectively overcome the bottlenecks of poor energy efficiency and limited cyclability for Li‐O2 batteries caused by passivation of insulating discharge products and unfavorable byproducts. Herein we report a novel soluble catalyst of bifunctional imidazolyl iodide salt additive, 1,3‐dimethylimidazolium iodide (DMII), to successfully construct highly efficient and durable Li‐O2 batteries. The anion I− can effectively promote the charge transport of Li2O2 and accelerate the redox kinetics of oxygen reduction/oxygen evolution reactions on the cathode side, thereby significantly decreasing the charge/discharge overpotential. Simultaneously, the cation DMI+ forms an ultrathin stably solid‐electrolyte interphase film on Li metal, greatly inhibiting the shuttle effect of I− and improving the stability of anode. Using this DMII additive, our Li‐O2 batteries achieve an extremely low voltage of 0.52 V and ultra‐long cycling stability over 960 h. Notably, up to 95.8 % of the Li2O2 yield further proves the reversible generation/decomposition of Li2O2 without the occurrence of side reactions. Both experimental and theoretical results disclose that DMII enables Li+ easily solvated, testifying the dominance of the solution‐induced reaction mechanism. This work provides the possibility to design the soluble catalysts towards high‐performance Li‐O2 batteries.