bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for emerging intraocular inflammation after intravitreal brolucizumab injection for age-related macular degeneration
Authors: Mukai Ryo , Matsumoto Hidetaka , Akiyama Hideo 
Published: December 2021

Purpose
To analyze the risk factors associated with emerging intraocular inflammation (IOI) after intravitreal brolucizumab injection (IVBr) to treat age-related macular degeneration (AMD).

Methods
This study included 93 eyes of 90 patients. The incidence of emerging IOI was analyzed. The patients were classified into IOI or non-IOI groups, and background clinical characteristics in each group were compared.

Results
IOI occurred in 14 eyes of 14 cases (16%; five women, nine men [5:9]; IOI group) after IVBr; contrastingly, no IOI occurred in 76 patients (10 women, 66 men [10:66]; non-IOI group). The mean ages in IOI and non-IOI groups were 79.4 ± 8.1 and 73.8 ± 8.9 years old, respectively, and the average age in the IOI group was significantly higher than that in the non-IOI group (P = 0.0425). In addition, the percentages of females in the IOI and non-IOI groups were 43% and 13%, respectively, and IOI occurred predominantly in females (odds ratio: 4.95, P = 0.0076). Moreover, the prevalence of diabetes in the IOI and non-IOI groups was 64% and 32%, respectively, with a significant difference (odds ratio: 3.90, P = 0.0196). In contrast, the prevalence of hypertension in the IOI and non-IOI groups was 36% and 57%, respectively, with no significant difference (P = 0.15).

Conclusion
The comparison of clinical profiles of IOI or non-IOI cases in IVBr treatment for AMD suggests that the risk factors for IOI are old age, female sex, and history of diabetes; however, IOI with vasculitis or vascular occlusion in this cohort does not seem to cause severe visual impairment. Further studies are required to investigate potential risk factors for IOI.
Analisis Karakteristik dan Potensi Tingkat Erosi Daerah Aliran Sungai Blorong Kabupaten Kendal Tahun 2013 dan 2018 Menggunakan Sistem Informasi Geografis dan Pendekatan Universal Soil Lost Equation (USLE)
Authors: Robbany Achmad Zakky , Setyorini Dhea Sarah , Riski Aldino Maulana , Widyastuti Santhi 
Published: December 2021

Peningkatan penduduk yang pesat mengakibatkan suatu daerah terus berkembang, salah satunya yaitu berada di Daerah Aliran Sungai (DAS) Blorong. DAS Blorong dengan luas area 208,20 km2 merupakan salah satu sub DAS bagian timur dari DAS Bodri-Kuto yang berada di kabupaten Semarang dan kabupaten Kendal. Penelitian memiliki tujuan untuk mengetahui karakteristik dan tingkat erosi di DAS Blorong. Metode yang digunakan untuk menghitung tingkat erosi di DAS Blorong yaitu menggunakan USLE (Universal Soil Loss Equation). Metode USLE yang dilakukan dengan Sistem Informasi Geografis (SIG) dengan mencari faktor-faktor untuk mendapatkan nilai USLE tersebut, beserta menganalisa karakteristik DAS dari data digital elevation model (DEM), peta tata guna lahan, peta geologi, dan curah hujan (tahun 2013 dan 2018). Pada DAS Blorong ditentukan karaktersitiknya berdasarkan hulu dan hilir dari DAS tersebut. Tingkat erosi yang terdapat pada DAS Blorong ditinjau dari tata guna lahan di DAS tersebut. Tingkat erosi di DAS Blorong pada tahun 2013 hingga 2018 terjadi peningkatan sebesar 10,78%, dari 852,236,26 ton/Ha/tahun menjadi 944.037,79 ton/Ha/tahun. Berdasarkan identifikasi dan perhitungan, menunjukkan bahwa curah hujan dan perubahan lahan pemukiman, agrikultur, dan ladang merupakan penyumbang terbesar erosi. Rekomendasi yang dapat dilakukan untuk meminimalisir potensi erosi adalah berupa upaya konservasi pada wilayah ini.
Analisis Ground Motion di Selatan Gunung Api Ungaran Berdasarkan Mikrozonasi Metode Horizontal to Vertical Spectral Ratio (HVSR)
Authors: Amrullah Muhammad Khemal , Aditama Maulana Rizki , Laksono Fx Anjar Tri , Widagdo Asmoro 
Published: December 2021

Salah satu mitigasi bencana yang dapat dilakukan untuk mengidentifikasi daerah yang berpotensi mengalami pergerakan tanah adalah analisis mikrotremor dengan metode Horizontal to Vertical Spectral Ratio (HVSR) yang menghasilkan parameter frekuensi dominan dan amplifikasi. Kedua data tersebut digunakan untuk mencari nilai indeks kerentanan seismik, ketebalan lapisan sedimen, dan peak ground acceleration yang dijadikan sebagai parameter untuk dianalisis dalam mengidentifikasi daerah yang berpotensi mengalami pergerakan tanah. Pada daerah penelitian nilai indeks kerentanan seismik terendah 0,15 s2/cm dan tertinggi 33,74 s2/cm, ketebalan sedimen paling tipis pada Vs 175 m/s adalah 3,24 m dan ketebalan lapisan sedimen paling tebal adalah 33,71 m, sedangkan pada Vs 350 m/s ketebalan paling tipis adalah 6,48 m dan ketebalan sedimen paling tebal adalah 67,43 m, serta nilai peak ground acceleration paling tinggi adalah 48,48 gal dan paling rendah adalah adalah 14,91 gal. Berdasarkan analisis data microtremor, nilai indeks kerentanan seismik, lapisan sedimen, depth of boundary, dan peak ground acceleration, daerah yang memiliki potensi pergerakan tanah yang relatif tinggi berada di titik MS12, MS14, MS15, MS20, MS21, dan MS23.
Complete consistency for the estimator of nonparametric regression model based on m-END errors
Authors: Zhang Shui-Li , Hou Tiantian , Qu Cong 
Published: December 2021

Abstract
In this paper, we study the complete consistency for the estimator of nonparametric regression model based on m-END errors and obtain the convergence rates of the complete consistency under more general conditions. Finally, some simulations are illustrated to verify the validity of our results.
Underinsurance Among Children in the United States
Authors: Yu Justin , Perrin James M. , Hagerman Thomas , Houtrow Amy J. 
Published: December 2021

OBJECTIVES
We describe the change in the percentage of children lacking continuous and adequate health insurance (underinsurance) from 2016 to 2019. We also examine the relationships between child health complexity and insurance type with underinsurance.

METHODS
Secondary analysis of US children in the National Survey of Children’s Health combined 2016–2019 dataset who had continuous and adequate health insurance. We calculated differences in point estimates, with 95% confidence intervals (CIs), to describe changes in our outcomes over the study period. We used multivariable logistic regression adjusted for sociodemographic characteristics and examined relationships between child health complexity and insurance type with underinsurance.

RESULTS
From 2016 to 2019, the proportion of US children experiencing underinsurance rose from 30.6% to 34.0% (+3.4%; 95% CI, +1.9% to +4.9%), an additional 2.4 million children. This trend was driven by rising insurance inadequacy (24.8% to 27.9% [+3.1%; 95% CI, +1.7% to +4.5%]), which was mainly experienced as unreasonable out-of-pocket medical expenses. Although the estimate of children lacking continuous insurance coverage rose from 8.1% to 8.7% (+0.6%), it was not significant at the 95% CI (−0.5% to +1.7%). We observed significant growth in underinsurance among White and multiracial children, children living in households with income ≥200% of the federal poverty limit, and those with private health insurance. Increased child health complexity and private insurance were significantly associated with experiencing underinsurance (adjusted odds ratio, 1.9 and 3.5, respectively).

CONCLUSIONS
Underinsurance is increasing among US children because of rising inadequacy. Reforms to the child health insurance system are necessary to curb this problem.
Active learning as enabler of sustainability learning outcomes: Capturing the perceptions of learners during a materials education workshop
Authors: Kioupi Vasiliki , Vakhitova Tatiana V. , Whalen Katherine A. 
Published: December 2021

AbstractActive learning is a promising teaching approach that can develop sustainability competences in learners. In this paper, we investigate the potential of active-learning pedagogies such as serious games and active-learning toolkits to deliver sustainability knowledge and skills in materials education. We organised a workshop for 20 participants from UK Universities where they played the serious game In the Loop around critical materials and circular economy and engaged in the Active-Learning ToolKit Sustainable Development (Granta Design/now Ansys UK Ltd.) to assess the sustainability of a proposed policy intervention around the use of electric cars. We used a self-assessment questionnaire and reflection sessions to deduce the level of sustainability skill developed by the participants as well as importance and performance analysis (IPA) to help the educators understand crucial components they should concentrate their teaching and learning efforts on in the future. Finally, we provide recommendations for educators on how to implement active learning in materials education in order to empower students with skills for sustainability.
Graphical abstract
Effect of Genetic / Environmental Influence on Growth of Newborn in Himachal Pradesh
Authors:   Department of Anatomy SLBS Govt. Medical College, Mandi at Nerchowk Himachal Pradesh, India., Rana Susheela , Mahajan Hemender ,   Department of Gynaecology SLBS Govt. Medical College, Mandi at Nerchowk Himachal Pradesh, India., Sharma Nalneesh ,   Department of Gynaecology SLBS Govt. Medical College, Mandi at Nerchowk Himachal Pradesh, India., Soni Pankaj ,   Department of Anatomy SLBS Govt. Medical College, Mandi at Nerchowk Himachal Pradesh, India.
Published: December 2021

Introduction: The effects of altitudinal variation on child growth and development have long been a center of attention for researcher. We believe that hereditary factor primarily affects on child growth and development however environment has secondary effect on it. The available literature on newborns in Himachal Pradesh establishes the fact that as altitude increases the crown heel length decreases. A comprehensive significant finding was also available in both the regions of Himachal Pradesh in terms of head length, foot length, nasal height etc. the comparison between the neonates of the two zones of Himachal Pradesh explains the difference in physical appearance of people of both zones. These features may be biological or behavioral in nature, genetic or developmental in origin. Most instances, a combination of factors are involved. Methods: The present study included 185 parents and their newborns from two zones (Lower zone and Middle zone) of Himachal Pradesh and separated as per the criteria. Measurement of newborn parameters was taken in 12-24 hours after birth by using digital vernier caliper. Ethical clearance from university and permission from Himachal Pradesh government was taken. All the newborns were separated as per criteria 1.	Mother / Father from Lower Zone. (Zone category 1) 2.	Mother / Father from Middle Zone. (Zone category 2) 3.	Mother from Lower Zone / Father from Middle Zone. (Zone category 3) 4.	Mother from Middle Zone / Father from Lower Zone. (Zone category 4) Results: Statistically significant difference was obtained in all the four categories. Different parameters were compared across different parent- zone categories by one way ANOVA. The results showed that four parameters shows significantly across groups, viz, Weight, Facial Length, Nasal Height and Philtrum width in all the Zone categories. Conclusions: The early historical studies mention that people living in Himachal Pradesh have migrated from different geographical locations hence their genetics, as well as culture is different from each other. This study clearly demonstrates the effects of environmental factors on child growth and development in Himachal Pradesh. KEY WORD: Anthropometry, Newborn, Himachal, Environment, Genetics.
Intézményi környezet és helyi fejlesztések: elköteleződések szabta lehetőségek a telepprogramok megvalósításában
Authors: Keller Judit , Virág Tünde 
Published: December 2021

A helyi tudásra és adottságokra építő fejlesztési megközelítés (place-based approach) több mint egy évtizede az Európai Unió (EU) kohéziós politikájának egyik meghatározó módszertani megközelítése. Célja a társadalmi kirekesztés és a térbeli-társadalmi egyenlőtlenségek enyhítése egy olyan többszintű kormányzási intézményrendszeren keresztül, amelyben a helyi kapacitásokat és tudásokat a fejlesztéspolitikai mező magasabb területi szintjeiről érkező, külső források bevonásával mobilizálják. A helyi adottságokból kiinduló fejlesztési paradigma kritikusai szerint az EU tagállamok közigazgatási és fejlesztéspolitikai intézményrendszere erősen heterogén, s ebből adódóan a helyi adottságokból kiinduló fejlesztési beavatkozások eltérően, különböző eredményességgel működhetnek az egyes országokban. Azaz, a helyi adottságokra építő fejlesztések mindig a nemzeti közigazgatási és fejlesztéspolitikai intézményrendszerben értelmezhetők, annak keretei, működési mechanizmusai, a különböző területi szintek közötti együttműködés, az információk és források áramlása, a kompetenciák és kapacitások megosztása meghatározza a helyi fejlesztések mozgásterét a fejlesztési koalíciók kialakítására és működtetésére, a helyi fejlesztési elképzelések és célok megvalósítására. A helyi adottságokra építő fejlesztések vizsgálatakor ezért egyszerre kell figyelembe venni a vertikális - különböző területi szintek intézményei - és a horizontális - helyi szinten kialakuló fejlesztési koalíciók és együttműködések – kapcsolatok, kompetencia és kapacitás megosztások jellemzőit, működési mechanizmusait. Tanulmányunkban bemutatjuk, hogy az állam által kialakított fejlesztéspolitika intézményi és szabályozási keretei milyen lehetőségeket kínálnak a helyi szintnek a „telepfelszámolás”, azaz a szegregációs folyamatok megállítása és a lakóhelyi szegregáció oldásának kezelésére, és egy jó gyakorlatként megjelenő esettanulmány alapján bemutatjuk, hogy ez mennyiben találkozik a helyi adottságokkal és tudással, valamint a helyi szinten megfogalmazódó igényekkel és lehetőségekkel, a fejlesztési elképzelések megvalósításához helyi szinten milyen erőforrásokat lehet és kell mozgósítani.
Mediation as a Negotiation Technology and Prospects for its Application in the Banking Sector
Authors: Arzumanova L. L. , Shevchuk P. P. 
Published: December 2021

The paper is devoted to the use of a negotiation technology and its variety—mediation—in the banking sector. It is emphasized that in recent years we have been talking about applied competencies that practicing lawyers are expected to possess in a certain area of their activity. In this regard, soft skills have become more important that need to be learned in the process of building relationships in a professional environment. Soft skills are universal socio-psychological qualities that do not depend on the professional suitability of an individual, but directly influence our success in the business environment. Mediation procedures can also be classified as soft skills. The case stydy of credit relations shows the positive aspects of the use of mediation in the banking sector. It should be noted that abroad such a procedure as mediation is used in a wide range of relations. Moreover, mediation is mandatory, i.e. it is considered as a mandatory pre-trial stage of dispute settlement.
A Blockchain in Concluding and Administering a Syndicated Loan Agreement
Authors: Chub D. V. 
Published: December 2021

A traditional banking market has undergone significant changes caused by rapid development of digital technologies, which has been largely facilitated by the coronavirus pandemic. At the same time, it seems that a blockchain technology has gained great importance in the issuance of syndicated loans. This circumstance is explained by the fact that a syndicated loan agreement, similar to the blockchain technology, traditionally brings together a large number of participants, including, in particular, borrowers, lenders, a loan manager, a mortgage manager. The paper substantiates the advantage of using the blockchain technology in structuring relations related to the provision of a syndicated loan to a borrower. Particular attention is paid to the legal status of a loan manager using blockchain technology to carry out his functions of organizing and administering a syndicated loan agreement. The paper explains the peculiarity of interaction between a credit manager and other parties to the syndicated loan agreement when using blockchain technology. Legislative changes are proposed aimed at providing syndicated lending participants with the opportunity to use blockchain to organize interaction between them.
The experience of laparoscopic-assisted vaginal hysterectomy
Authors: Plekhanov A. N. , Zhemchuzhina T. Y. 
Published: December 2021

In our clinic we have been using laparoscopic- assisted vaginal hysterectomy since 1996. Our experience of LAVH amounts to 103 operations. The investigations we carried out confirmed undoubted advantages of laparoscopic-assisted vaginal hysterectomy over other methods in question. The technique used by us resulted in decreasing of complications and extended the number of indications.
Summarizing everything mentioned above we can draw the conclusion that laparoscopic-assisted vaginal hysterectomy has the following advantages: minimal traumatization, favorable cosmetic effect, shot postoperative and rehabilitation period, absence of complications in the late postoperative period, decrease of the risk of intraoperative complications and absence of absolute contraindications. The experience accumulated proves the LAVH technique to be reasonable and efficient.
The role of erythropoietin in the pathogenesis and treatment of iron deficiency anemia during pregnancy and in the postpartum period
Authors: Ailamazyan Eduard K. , Tarasova М. A. , Zaitsev А. А. , Samarina А. V. 
Published: December 2021

Iron deficiency anemia (IDA) is a very common pathological condition during pregnancy and the postpartum period. In the structure of hematological diseases in pregnant women, anemias account for about 90% and in most cases are iron deficient [3, 17, 19]. In the third trimester of pregnancy and in the early postpartum period, almost every woman has a latent iron deficiency, and 3040% develop IDA [4, 15, 16, 20, 26]. According to the Ministry of Health of the Russian Federation, the frequency of IDA in Russia has increased 6.3 times over the past ten years, and in St. Petersburg - almost 2 times.
The development of anemia during pregnancy is due to an imbalance of iron in the body and is associated with its increased costs for creating a fetoplacental complex, an increase in iron metabolism and a redistribution of this trace element in favor of the fetus. Iron deficiency in the body of pregnant women and women in childbirth is associated with inadequate replacement of losses due to alimentary and mobilized iron.
The Readability Level of Arabic Textbook “Silsilah Fī Ta’līm al-Lughah al-‘Arabiyyah”
Authors: Zulharby Puti , Marzuq Ahmad , Ritonga Aziz 
Published: December 2021

The purpose of this study was to know the readability level of textbook "Silsilah Fī Ta’līm al-Lughah al-‘Arabiyyah: Al-Mustawā Ats-Tsāniy, Al-Qirā`ah", and factors affecting readability level in terms of word class tendencies and linguistic findings. This study also analyzed the level of reading ability of first-semester Arabic students at Universitas Negeri Jakarta and the types of texts recommended for use or further development by other researchers. This research was carried out using descriptive qualitative methods, and data were collected from 83 students who enrolled in the Qirā`ah course. Readability analysis techniques using the Cloze Procedure Test. The research showed that the readability of textbooks was 46% at the frustration level and 29% at the moderate level. The tendency of the word class to make errors generally occur in 1) 27% of perfect verbs, 2) 24% of nouns, 3) 16% of imperfect verbs. Other factors are 1) Reader Factor: about 43% of students in the Arabic Language Education Department come from general/vocational high schools, 35% from Islamic high school, and only 22% from Islamic boarding schools; 2) Reading Factor: the textbooks writers from native Arabic speakers generally rely on their experience and culture in presenting the text regardless of readers ability as foreign speakers. 3) Book Factor: this book lacks vocabulary and illustrations in the form of pictures, so that it was less helpful in independent understanding.
A prebreeding study of introgression spring bread wheat lines carrying combinations of stem rust resistance genes, Sr22+Sr25 and Sr35+Sr25
Authors: Sibikeev S. N. , Baranova O. A. , Druzhin A. E. 
Published: December 2021

The Sr22, Sr35, and Sr25 genes attract the attention of bread wheat breeders with their effectiveness against Puccinia graminis f. sp. tritici race Ug99 and its biotypes. The effectiveness and impact of Sr22+Sr25 and Sr35+Sr25 gene combinations on agronomic traits have not yet been studied. In the present article, these traits were studied using the spring bread wheat lines L503/W3534//L503, L503/Sr35//L503/3/L503 carrying the Sr22+Sr25 and Sr35+Sr25 genes during 2016–2020. These lines were assessed for resistance to P. graminis f. sp. tritici under natural epiphytotics and to the Saratov, Lysogorsk and Omsk populations of the pathogen and to the PgtZ1 (TKSTF) and PgtF18.6 fungus isolates in laboratory conditions (TKSTF + Sr33). The presence of the studied Sr-genes was confirmed by using molecular markers. Prebreeding studies were conducted during 2018–2020 vegetation periods. Under the natural epiphytotics of the pathogen and in the laboratory conditions, the Sr22+Sr25 combination was highly effective, while Sr35+Sr25 was ineffective. For grain yield, the lines with the Sr22+Sr25 and Sr35+Sr25 genes were superior to the recipient cultivar L503 in one year (Sr22+Sr25 in 2019; Sr35+Sr25 in 2018), with a decrease in 2020, but in general there were no differences. For the period 2018–2020, both combinations showed a decrease in 1000 grains weight and an increase in the germination-earing period. The line with Sr22+Sr25 genes showed insignificant effects on gluten and dough tenacity, but the ratio of dough tenacity to extensibility was higher, and flour strength, porosity and bread volume were lower; in the line with Sr35+Sr25 genes, the gluten content was lower, but the strength, tenacity of the dough and the ratio of dough tenacity to extensibility were higher, flour strength and the porosity of the bread were at the recipient level, but the volume of bread was lower.
An Efficient Spatial-Temporal Convolution Recurrent Neural Network Surrogate Model for History Matching
Authors: Ma Xiaopeng , Zhang Kai , Wang Jian , Yao Chuanjin , Yang Yongfei , Sun Hai , Yao Jun 
Published: December 2021

Summary
Surrogate modeling has shown to be effective in improving the solving efficiency for history matching in the development of oil and gas, but the traditional surrogate models are difficult to directly deal with the high-dimensional spatial uncertain parameters, such as the permeability field. In this paper, we introduce a new deep-learning-based surrogate modeling framework, image-to-sequence regression, which can directly predict the production data from the high-dimensional spatial parameters. Specifically, a spatial-temporal convolution recurrent neural network surrogate model is proposed based on a densely connected convolutional neural network (CNN) model and a stacked multilayer long short-term memory (LSTM) model. And a surrogate-based history-matching workflow is then developed by combining the proposed surrogate model with an improved ensemble smoother data assimilation algorithm. Two case studies on a 2D and a 3D reservoir model demonstrate that the proposed surrogate model can effectively predict production data and improve the efficiency of history matching.