bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-scale and multi-parametric radiomics of gadoxetate disodium–enhanced MRI predicts microvascular invasion and outcome in patients with solitary hepatocellular carcinoma ≤ 5 cm
Authors: Chong Huan-Huan , Yang Li , Sheng Ruo-Fan , Yu Yang-Li , Wu Di-Jia , Rao Sheng-Xiang , Yang Chun , Zeng Meng-Su 
Published: January 2021

Abstract
Objectives
To develop radiomics-based nomograms for preoperative microvascular invasion (MVI) and recurrence-free survival (RFS) prediction in patients with solitary hepatocellular carcinoma (HCC) ≤ 5 cm.

Methods
Between March 2012 and September 2019, 356 patients with pathologically confirmed solitary HCC ≤ 5 cm who underwent preoperative gadoxetate disodium–enhanced MRI were retrospectively enrolled. MVI was graded as M0, M1, or M2 according to the number and distribution of invaded vessels. Radiomics features were extracted from DWI, arterial, portal venous, and hepatobiliary phase images in regions of the entire tumor, peritumoral area ≤ 10 mm, and randomly selected liver tissue. Multivariate analysis identified the independent predictors for MVI and RFS, with nomogram visualized the ultimately predictive models.

Results
Elevated alpha-fetoprotein, total bilirubin and radiomics values, peritumoral enhancement, and incomplete or absent capsule enhancement were independent risk factors for MVI. The AUCs of MVI nomogram reached 0.920 (95% CI: 0.861–0.979) using random forest and 0.879 (95% CI: 0.820–0.938) using logistic regression analysis in validation cohort (n = 106). With the 5-year RFS rate of 68.4%, the median RFS of MVI-positive (M2 and M1) and MVI-negative (M0) patients were 30.5 (11.9 and 40.9) and > 96.9 months (p < 0.001), respectively. Age, histologic MVI, alkaline phosphatase, and alanine aminotransferase independently predicted recurrence, yielding AUC of 0.654 (95% CI: 0.538–0.769, n = 99) in RFS validation cohort. Instead of histologic MVI, the preoperatively predicted MVI by MVI nomogram using random forest achieved comparable accuracy in MVI stratification and RFS prediction.

Conclusions
Preoperative radiomics-based nomogram using random forest is a potential biomarker of MVI and RFS prediction for solitary HCC ≤ 5 cm.

Key Points
• The radiomics score was the predominant independent predictor of MVI which was the primary independent risk factor for postoperative recurrence.
• The radiomics-based nomogram using either random forest or logistic regression analysis has obtained the best preoperative prediction of MVI in HCC patients so far.
• As an excellent substitute for the invasive histologic MVI, the preoperatively predicted MVI by MVI nomogram using random forest (MVI-RF) achieved comparable accuracy in MVI stratification and outcome, reinforcing the radiologic understanding of HCC angioinvasion and progression.
Vascular and haemodynamic issues of brain ageing
Authors: Beishon Lucy , Clough Rebecca H. , Kadicheeni Meeriam , Chithiramohan Tamara , Panerai Ronney B. , Haunton Victoria J. , Minhas Jatinder S. , Robinson Thompson G. 
Published: January 2021

AbstractThe population is ageing worldwide, thus increasing the burden of common age-related disorders to the individual, society and economy. Cerebrovascular diseases (stroke, dementia) contribute a significant proportion of this burden and are associated with high morbidity and mortality. Thus, understanding and promoting healthy vascular brain ageing are becoming an increasing priority for healthcare systems. In this review, we consider the effects of normal ageing on two major physiological processes responsible for vascular brain function: Cerebral autoregulation (CA) and neurovascular coupling (NVC). CA is the process by which the brain regulates cerebral blood flow (CBF) and protects against falls and surges in cerebral perfusion pressure, which risk hypoxic brain injury and pressure damage, respectively. In contrast, NVC is the process by which CBF is matched to cerebral metabolic activity, ensuring adequate local oxygenation and nutrient delivery for increased neuronal activity. Healthy ageing is associated with a number of key physiological adaptations in these processes to mitigate age-related functional and structural declines. Through multiple different paradigms assessing CA in healthy younger and older humans, generating conflicting findings, carbon dioxide studies in CA have provided the greatest understanding of intrinsic vascular anatomical factors that may mediate healthy ageing responses. In NVC, studies have found mixed results, with reduced, equivalent and increased activation of vascular responses to cognitive stimulation. In summary, vascular and haemodynamic changes occur in response to ageing and are important in distinguishing “normal” ageing from disease states and may help to develop effective therapeutic strategies to promote healthy brain ageing.
From scenario-based seismic hazard to scenario-based landslide hazard: rewinding to the past via statistical simulations
Authors: Luo Luguang , Lombardo Luigi , van Westen Cees , Pei Xiangjun , Huang Runqiu 
Published: January 2021

AbstractThe vast majority of statistically-based landslide susceptibility studies assumes the slope instability process to be time-invariant under the definition that “the past and present are keys to the future”. This assumption may generally be valid. However, the trigger, be it a rainfall or an earthquake event, clearly varies over time. And yet, the temporal component of the trigger is rarely included in landslide susceptibility studies and only confined to hazard assessment. In this work, we investigate a population of landslides triggered in response to the 2017 Jiuzhaigou earthquake ($$M_w = 6.5$$

M
w

=
6.5

) including the associated ground motion in the analyses, these being carried out at the Slope Unit (SU) level. We do this by implementing a Bayesian version of a Generalized Additive Model and assuming that the slope instability across the SUs in the study area behaves according to a Bernoulli probability distribution. This procedure would generally produce a susceptibility map reflecting the spatial pattern of the specific trigger and therefore of limited use for land use planning. However, we implement this first analytical step to reliably estimate the ground motion effect, and its distribution, on unstable SUs. We then assume the effect of the ground motion to be time-invariant, enabling statistical simulations for any ground motion scenario that occurred in the area from 1933 to 2017. As a result, we obtain the full spectrum of potential coseismic susceptibility patterns over the last century and compress this information into a hazard model/map representative of all the possible ground motion patterns since 1933. This backward statistical simulations can also be further exploited in the opposite direction where, by accounting for scenario-based ground motion, one can also use it in a forward direction to estimate future unstable slopes.
H2020 – ROBOMINERS
Authors: Berner Michael , Sifferlinger Nikolaus August 
Published: January 2021

ZusammenfassungDer folgende Artikel beschäftigt sich mit dem EU-H2020 Projekt ROBOMINERS mit Schwerpunkt auf den Aufgaben der Montanuniversität Leoben, die die Entwicklung der Abbaueinheit eines kleinen Bergbauroboters umfassen. Die einzelnen Technologien werden hinsichtlich ihrer Effizienz und Machbarkeit bewertet, indem vorhandene Technologien untersucht und analytische Studien, Simulationen bis hin zu Konzeptentwicklungen durchgeführt werden. Dies beinhaltet konventionelle, alternative und kombinierte Abbaumethoden. Der Beitrag dieser Arbeit soll weiters eine Richtlinie zur Anwendbarkeit potenzieller Abbaumethoden für Bergbau-Roboter in unterschiedlichen Klassen liefern.
The hamster wheel: a case study on embodied narrative identity and overcoming severe obesity
Authors: Natvik Eli , Råheim Målfrid , Sviland Randi 
Published: January 2021

AbstractBased in narrative phenomenology, this article describes an example of how lived time, self and bodily engagement with the social world intertwine, and how our sense of self develops. We explore this through the life story of a woman who lost weight through surgery in the 1970 s and has fought against her own body, food and eating ever since. Our narrative analysis of interviews, reflective notes and email correspondence disentangled two storylines illuminating paradoxes within this long-term weight loss process.Thea’s Medical Weight Narrative: From Severely Obese Child to Healthy Adultis her story in context of medicine and obesity treatment and expresses success and control.Thea’s Story: The Narrative of Fighting Weightis the experiential story, including concrete examples and quotes, highlighting bodily struggles and the inescapable ambiguity of being and having one’s body. The two storylines coexist and illuminate paradoxes within the weight loss surgery narrative, connected to meaningful life events and experiences, eating practices and relationships with important others. Surgery was experienced as lifesaving, yet the surgical transformation did not suffice, because it did not influence appetite or, desire for food in the long run. In the medical narrative of transforming the body by repair, a problematic relationship with food did not fit into the plot.
Assessing Microbial Communities Related to Mercury Transformations in Contaminated Streambank Soils
Authors: Abdelmageed Yazeed , Miller Carrie , Sanders Carrie , Egbo Timothy , Johs Alexander , Robertson Boakai 
Published: January 2021

AbstractIn nature, the bioaccumulative potent neurotoxin methylmercury (MeHg) is produced from inorganic mercury (Hg) predominantly by anaerobic microorganisms. Hg-contaminated soils are a potential source of MeHg due to microbial activity. We examine streambank soils collected from the contaminated East Fork Poplar Creek (EFPC) in Tennessee, USA, where seasonal variations in MeHg levels have been observed throughout the year, suggesting active microbial Hg methylation. In this study, we characterized the microbial community in contaminated bank soil samples collected from two locations over a period of one year and compared the results to soil samples from an uncontaminated reference site with similar geochemistry (n = 12). Microbial community composition and diversity were assessed by 16S rRNA gene amplicon sequencing. Furthermore, to isolate potential methylators from soils, enrichment cultures were prepared using selective media. A set of three clade-specific primers targeting the genehgcAwere used to detect Hg methylators among the δ-Proteobacteria in EFPC bank soils across all seasons. Two families among the δ-Proteobacteria that have been previously associated with Hg methylation, Geobacteraceae and Syntrophobacteraceae, were found to be predominant with relative abundances of 0.13% and 4.0%, respectively. However, in soil enrichment cultures, Firmicutes were predominant among families associated with Hg methylation. Specifically, Clostridiaceae and Peptococcaceae and their generaClostridiumandDesulfosporosinuswere among the ten most abundant genera with relative abundances of 2.6% and 1.7%, respectively. These results offer insights into the role of microbial communities on Hg transformation processes in contaminated bank soils in EFPC. Identifying the biogeochemical drivers of MeHg production is critical for future remediation efforts.
Präsentismus in der Hochschule
Authors: Komp Rebecca , Ianiro-Dahm Patrizia , Kauffeld Simone 
Published: January 2021

Zusammenfassung
Hintergrund
Empirische Studien zeigen, dass mehr als zwei Drittel der Beschäftigten trotz Krankheit zur Arbeit gehen. Dieser sog. Präsentismus bringt sowohl gesundheitliche und motivationale Risiken für die Mitarbeiter als auch wirtschaftliche Risiken für die Organisation mit sich.

Ziel der Arbeit
Die durchgeführten Studien fokussieren Möglichkeiten zur Verringerung der negativen gesundheitlichen Effekte und entwickeln Maßnahmen zur generellen Vermeidung von Präsentismus am spezifischen Setting Hochschule.

Methode
An einer deutschen Hochschule erfolgte eine quantitative Befragung (n = 308) zur Prävalenz von Präsentismus, dessen Zusammenhang mit körperlichen Beschwerden untersucht wurde. Weiterhin wurden potenziell moderierende Effekte der Ressourcen Erholung, Achtsamkeit und Work-Life-Balance (WLB) betrachtet. Eine qualitative Studie explorierte auf Grundlage von Interviews (n = 11, qualitative Inhaltsanalyse) Gründe für Präsentismus und potenzielle Maßnahmen, um diesem entgegenzuwirken.

Ergebnisse
Die quantitativen Ergebnisse zeigen, dass Präsentismus im Hochschulkontext vertreten ist und körperliche Beschwerden begünstigt. Die Ressourcen Erholung, Achtsamkeit und WLB können bei hoher Ausprägung die negativen gesundheitlichen Effekte von Präsentismus abschwächen. Bei niedriger Ausprägung verstärken sie die Effekte. Die qualitative Analyse machte deutlich, dass quantitative Arbeitsbelastung, Pflichtgefühl sowie das Gefühl, noch leistungsfähig zu sein, zentrale Gründe für Präsentismus sind und zum Beispiel die Unterstützung eines gesundheitsförderlichen Organisationsklimas oder Vertretungsregelungen geeignete Gegenmaßnahmen darstellen.

Diskussion
Die Ergebnisse werden vor dem Hintergrund verhaltens- und verhältnispräventiver Maßnahmen diskutiert und praktische Implikationen abgeleitet.
Molecular breeding of sporeless strains of Pleurotus ostreatus using a non-homologous DNA end-joining defective strain
Authors: Yamasaki Fuga , Nakazawa Takehito , Sakamoto Masahiro , Honda Yoichi 
Published: January 2021

AbstractGene targeting is useful to isolate strains with mutations in a gene of interest for efficient breeding. In this study, we generated msh4 or mer3 single-gene disruptant monokaryons using a Pleurotus ostreatus Δku80 strain for efficient gene targeting. Dikaryons of P. ostreatus Δmsh4×Δmsh4 or Δmer3×Δmer3 were isolated via backcrosses, and the number of basidiospores produced was measured. The number of basidiospores fell by an average 1/13.7 in the P. ostreatus Δmsh4×Δmsh4 dikaryons versus the P. ostreatus msh4+×Δmsh4 dikaryons, and 1/82.6 in the P. ostreatus Δmer3×Δmer3 dikaryons versus the P. ostreatus mer3+×Δmer3 dikaryons. To demonstrate the effects of ku80 disruption, P. ostreatus Δku80×Δku80 dikaryon strains were isolated and no significant effects on basidiospore production were observed. Fluorescence microscopy showed meiotic progression was arrested during prophase I in the msh4 or mer3 disruptants. To our knowledge, this is the first report on molecular breeding of sporeless strains in cultivated mushrooms using an efficient method for targeted gene disruption.
Stereotactic Body Radiation Therapy (SBRT) in Hepatocellular Carcinoma
Authors: Thomas Horatio R. , Feng Mary 
Published: January 2021

Abstract
Purpose of Review
Hepatocellular carcinoma (HCC) is a rising cause of mortality and morbidity, and although surgical resection is the preferred curative local therapy, < 30% of patients are candidates at diagnosis. This review discusses SBRT as an option in a variety of clinical scenarios.

Recent Findings
Multiple retrospective and prospective studies demonstrate that stereotactic body radiation therapy (SBRT) is an effective bridge for transplant candidates and local therapy for patients with inoperable early-, intermediate-, or advanced-stage disease. SBRT is associated with excellent local control, and it is well-tolerated despite study cohorts enriched with patients who failed prior therapies and had poor baseline liver function.

Summary
Additional randomized control trials are needed to determine the ideal treatment regimen and patient selection for SBRT.
Focus on radioiodine-131 biokinetics: the influence of methylprednisolone on intratherapeutic effective half-life of 131I during radioiodine therapy of Graves’ disease
Authors: Happel C. , Kranert W. T. , Gröner D. , Baumgarten J. , Halstenberg J. , Bockisch B. , Sabet A. , Grünwald F. 
Published: January 2021

Abstract
Aim
Radioiodine therapy (RIT) may trigger the development of Graves’ ophthalmopathy (GO) or exacerbate pre-existing subclinical GO. Therefore, glucocorticoid administration is recommended for patients with pre-existing GO. Aim of this study was to analyze the influence of glucocorticoid therapy with methylprednisolone on intratherapeutic effective half-life (EHL) of radioiodine-131 in patients with Graves’ disease (GD) as recent studies showed an effect for prednisolone.

Methods
In a retrospective study, 264 patients with GD who underwent RIT without any additional antithyroid medication were evaluated. Intrathyroidal EHL was determined pre- and intratherapeutically. Patients with co-existing GO (n = 43) received methylprednisolone according to a fixed scheme starting 1 day prior to RIT, patients without GO (n = 221) did not receive any protective glucocorticoid medication. The ratios of EHL during RIT and during radioiodine uptake test (RIUT) were compared.

Results
Patients receiving methylprednisolone showed a slight decrease of the mean EHL from 5.63 d (RIUT) to 5.39 d (RIT) (p > 0.05). A comparable result was obtained in patients without glucocorticoids (5.71 d (RIUT) to 5.47 d (RIT); p > 0.05). The ratios of the EHL between RIT and RIUT failed to show a significant difference between the two groups. EHL is therefore not significantly influenced by an additional protective treatment with methylprednisolone.

Conclusions
In the present study a decreased intrathyroidal EHL under glucocorticoid medication with methylprednisolone could not be detected. Therefore, co-medication with methylprednisolone in patients with GO may be preferred to avoid an intratherapeutic decrease of EHL by accompanying protective glucocorticoides.
Modelling of total dissolved solids in water supply systems using regression and supervised machine learning approaches
Authors: Ewusi Anthony , Ahenkorah Isaac , Aikins Derrick 
Published: January 2021

AbstractMonitoring of water quality through accurate predictions provides adequate information about water management. In the present study, three different modelling approaches: Gaussian process regression (GPR), backpropagation neural network (BPNN) and principal component regression (PCR) models were used to predict the total dissolved solids (TDS) as water quality indicator for the water quality management. The performance of each model was evaluated based on three different sets of inputs from groundwater (GW), surface water (SW) and drinking water (DW). The GPR, BPNN and PCR models used in this study gave an accurate prediction of the observed data (TDS) in GW, SW and DW, with the R2 consistently greater than 0.850. The GPR model gave a better prediction of TDS concentration, with an average R2, MAE and RMSE of 0.987, 4.090 and 7.910, respectively. For the BPNN, an average R2, MAE and RMSE of 0.913, 9.720 and 19.137, respectively, were achieved, while the PCR gave an average R2, MAE and RMSE of 0.888, 11.327 and 25.032, respectively. The performance of each model was assessed using efficiency based indicators such as the Nash and Sutcliffe coefficient of efficiency (ENS) and the index of agreement (d). The GPR, BPNN and PCR models, respectively, gave an ENS of (0.967, 0.915, 0.874) and d of (0.992, 0.977, 0.965). It is understood from this study that advanced machine learning approaches (e.g. GPR and BPNN) are appropriate for the prediction of water quality indices and would be useful for future prediction and management of water quality parameters of various water supply systems in mining communities where artificial intelligence technology is yet to be fully explored.
Hyperuricaemia, gout and allopurinol in the CKD Queensland registry
Authors: Jeyaruban A. , Hoy W. , Cameron A. , Healy H. , Wang Z. , Zhang J. , Mallett A. 
Published: January 2021

Abstract
Introduction
There is scant data on the role of hyperuricaemia, gout and allopurinol treatment in chronic kidney disease (CKD). Therefore, our aim is to investigate the possible associations between hyperuricaemia, gout, prescription of allopurinol and renal outcomes in patients with CKD.

Methods
The retrospective cohort study involved 1123 Royal Brisbane and Women’s Hospital (RBWH) patients, enrolled in the CKD.QLD registry from May 2011 to August 2017. Patients were divided into two uric acid categories, with uric acid ≤ 0.36 mmol/L and > 0.36 mmol/L. Association of delta estimated glomerular filtration rate (eGFR) with gout, allopurinol treatment and hyperuricaemia were analysed.

Results
Patients with an entry urate > 0.36 mmol/L were older, had higher body mass index (BMI) and worse baseline kidney function. Proportion of patients with gout, hyperuricaemia and allopurinol treatment increased with advanced CKD stages. Age-adjusted analysis revealed a significant association between serum urate level and delta eGFR, with no significant association between gout, treatment with allopurinol and delta eGFR. Furthermore, neither gout nor the prescription of allopurinol had a significant effect on the time to renal death (composite end point of kidney replacement therapy or death).

Conclusion
Hyperuricaemia seemed to be independently associated with faster CKD progression or renal death. This was not observed with gout or prescription of allopurinol. Furthermore, allopurinol was not associated with decreased incidence of cardiovascular events. These data suggest that hyperuricaemia is likely the effect and not the cause of CKD or CKD progression.

Graphic abstract
Dwell Time Algorithm Based on Bounded Constrained Least Squares Under Dynamic Performance Constraints of Machine Tool in Deterministic Optical Finishing
Authors: Zhang Yunfei , Fang Fengzhou , Huang Wen , Fan Wei 
Published: January 2021

AbstractThe dwell time algorithm is one of the most important techniques within the deterministic optical surfacing technologies. The existing dwell time algorithms are generally based on non-negative least squares (NNLS) without considering the dynamic performance constraints of machine tools. This is a circumstance that leads to poor convergence accuracy. In this paper, a dwell time algorithm, based on bounded constrained least-squares (BCLS) under dynamic performance constraints of the machine tool, has been developed. The upper and lower constraints of the dwell time model could be derived through the acceleration and deceleration mechanism of the CNC (Computer Numerical Control) machine tools. A two-metric projection Newton iteration algorithm was used to solve the large-scale dwell time model, which greatly improved the computation efficiency. The results of the experiments and simulations showed that the proposed algorithm will give a very high convergence accuracy for optical finishing with machine tools with different dynamic performances. When the machine acceleration was set to a value as low as 0.1 g, the accuracies of the surface figures PV (Peak-to-Valley) and RMS (Root Mean Square) till improved by 40.8% and 55.2%, respectively, when using the BCLS algorithm. The influences of different dynamic performances of the machine tools on the dwell time solutions have also been investigated, which will provide a good guidance in the design of deterministic polishing machine tools.