bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERENCANAAN SUMUR RESAPAN DAN SALURAN DRAINASE PADA PERUMAHAN CHANDRA KIRANA REGENCY KECAMATAN SINGOSARI, KABUPATEN MALANG
Authors: Adi Zulfikar, Moch. Suaib Reiza, Suhartono Ryan Wahyu 
Published: April 2021

Six hectares Chandra Kirana Regency comprises 223 units. It needs a proper 1854 m drainage system completed with run-off water tanks to avoid it from floods.The objective of the study is to design the drainage system and run-off water tanks able to control the rainwater completed with the implementation cost and time.Site plan, topographic map, and rainfall data were needed to design. Rainfall data from 3 nearby stations: Singosari, Jabung, and Blimbing from 1991-2010 were analyzed to find out the maximum rainfall data and average rainfall regions using Mean Algebra. Log Pearson III was employed to obtain the rainfall, Mononobe method was for the rainfall intensity.The addition of rain water to waste water results in 0,00004 m/sec. cumulative discharge. Based on the result, and 0,5 m diameter culvert rings are designed. 1 m diameter and 2 m deep run-off water tank is of precast concrete. 93 work days implementation time at IDR 1.061.479.450,00.Keywords: design, drainage system, proper, rainwater, water tank
STUDI REKAYASA NILAI (VALUE ENGINEERING) PERENCANAAN PEMBANGUNAN GEDUNG PERPUSTAKAAN DAN AUDITORIUM UNIVERSITAS YUDHARTA PASURUAN
Authors: Khamim, Winda Harsanti Moch. 
Published: April 2021

Dalam Rencana Anggaran Biaya Pembangunan Gedung Perpustakaan dan Auditorium Universitas Yudharta Pasuruan, diperkirakan memerlukan biaya milyaran rupiah. Disamping karena volume pekerjaan yang besar, spesifikasi item pekerjaannya yang tinggi, dan munculnya berbagai jenis material untuk jenis pekerjaan yang sama.Sehubungan dengan hal tersebut diatas, perlu diusahakan suatu metode untuk mengurangi biaya tanpa mengurangi fungsi bangunan. Salah satu metode untuk meminimalkan biaya adalah Studi Rekayasa Nilai (Value Engineering), yaitu usaha yang terorganisir yang diarahkan untuk menganalisa fungsi yang diperlukan dengan biaya seminimal mungkin dengan tahapan spekulasi, tahapan perhitungan life cycle cost, dan tahapan pengembangan dan rekomendasi.Hasil studi yaitu penghematan biaya sebesar 1.533.129.685,81 atau 19.13 % dari biaya total proyek.Kata-kata kunci: rencana anggaran biaya, value enginering, prosentase penghematan
Development of Sustainable Alkali-Activated Mortars Using Fe-Rich Fayalitic Slag as the Sole Solid Precursor
Authors: Adediran Adeolu , Yliniemi Juho , Illikainen Mirja 
Published: April 2021

Graphical AbstractDevelopment of sustainable alkali-activated mortars using Fe-rich fayalitic slag as the sole solid precursor.
A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth
Authors: Solano-Collado Virtu , Colamarino Rosa Angela , Calderwood David A. , Baldassarre Massimiliano , Spanò Stefania 
Published: April 2021

SalmonellaTyphi is a human-restricted bacterial pathogen that causes typhoid fever, a life-threatening systemic infection. A fundamental aspect ofS. Typhi pathogenesis is its ability to survive in human macrophages but not in macrophages from other animals (i.e. mice). Despite the importance of macrophages in establishing systemicS. Typhi infection, the mechanisms that macrophages use to control the growth ofS. Typhi and the role of these mechanisms in the bacterium’s adaptation to the human host are mostly unknown. To facilitate unbiased identification of genes involved in controlling the growth ofS. Typhi in macrophages, we report optimized experimental conditions required to perform loss-of function pooled shRNA screens in primary mouse bone-marrow derived macrophages. Following infection with a fluorescent-labeledS. Typhi, infected cells are sorted based on the intensity of fluorescence (i.e. number of intracellular fluorescent bacteria). shRNAs enriched in the fluorescent population are identified by next-generation sequencing. A proof-of-concept screen targeting the mouse Rab GTPases confirmed Rab32 as important to restrictS. Typhi in mouse macrophages. Interestingly and rather unexpectedly, this screen also revealed that Rab1b controlsS. Typhi growth in mouse macrophages. This constitutes the first report of a Rab GTPase other than Rab32 involved inS. Typhi host-restriction. The methodology described here should allow genome-wide screening to identify mechanisms controlling the growth ofS. Typhi and other intracellular pathogens in primary immune cells.
Clinical Utility of Fluid Volume Assessment in Heart Failure Patients Using Bioimpedance Spectroscopy
Authors: Accardi Andrew J. , Matsubara Bradley S. , Gaw Richelle L. , Daleiden-Burns Anne , Heywood James Thomas 
Published: April 2021

Background:Bioimpedance spectroscopy (BIS) is a non-invasive method used to measure fluid volumes. In this report, we compare BIS measurements from patients with heart failure (HF) to those from healthy adults, and describe how these point-of-care fluid volume assessments may be applied to HF management.Methods and results:Fluid volumes were measured in 64 patients with NYHA class II or III HF and 69 healthy control subjects. BIS parameters including extracellular fluid (ECF), intracellular fluid (ICF), total body water (TBW), and ECF as a percentage of TBW (ECF%TBW) were analyzed. ECF%TBW values for the HF and control populations differed significantly (49.2 ± 3.2% vs. 45.2 ± 2.1%, respectively;p&lt; 0.001); both distributions satisfied criteria for normality. Interquartile ranges did not overlap (46.7–51.0% vs. 43.8–46.4%, respectively;p&lt; 0.001). Subgroup analyses of HF patients who underwent transthoracic echocardiography showed that impedance measurements correlated with inferior vena cava size (Pearson correlation −0.73,p&lt; 0.0001). A case study is presented for illustrative purposes.Conclusions:BIS-measured ECF%TBW values were significantly higher in HF patients as compared to adults without HF. We describe three strata of ECF%TBW (normal, elevated, fluid overload) that may aid in clinical risk stratification and fluid volume monitoring of HF patients.Clinical Trial Registration:COMPARE –www.ClinicalTrials.gov; IMPEL –www.ClinicalTrials.gov; Heart Failure at Home –www.ClinicalTrials.gov, identifier: NCT02939053; NCT02857231; NCT04013373.
Programmed Death-1/Programmed Death-Ligand 1-Axis Blockade in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Stratified by Human Papillomavirus Status: A Systematic Review and Meta-Analysis
Authors: Xu Yimin , Zhu Gangcai , Maroun Christopher A. , Wu Irene X. Y. , Huang Donghai , Seiwert Tanguy Y. , Liu Yong , Mandal Rajarsi , Zhang Xin 
Published: April 2021

BackgroundProgrammed death-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors have provided clinical benefit to head and neck squamous cell carcinoma (HNSCC) patients in recent clinical trials. However, it remains unclear as to whether human papillomavirus (HPV) status is associated with improved clinical outcome of anti-PD-1 or anti-PD-L1 immunotherapy in HNSCC.MethodsPubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched up to February 28, 2021. Published clinical trials of HNSCC patients treated with only PD-1 or PD-L1 inhibitors were selected. The primary or secondary outcome of these studies included objective response rate (ORR) stratified by HPV status. The pooled odds ratio (OR) and hazard ratio (HR) were estimated using a fixed-effect model.ResultsA total of seven eligible studies comprising 814 patients were included. The ORR of HPV positive HNSCC patients was significantly higher than that of HPV negative HNSCC patients (OR = 1.77; 95%CI = 1.14-2.74; P = 0.01), and this favorable effect occurred in pooled anti-PD-L1 trials (OR = 2.66; 95%CI = 1.16-6.11; P = 0.02). In comparison, the pooled OR was 1.51 in anti-PD-1 trials (95%CI = 0.90-2.54; P = 0.12). Survival analysis indicated that HPV positive HNSCC patients had a lower risk of overall death as compared to HPV negative HNSCC patients (HR = 0.77; 95%CI = 0.60–0.99; P = 0.04).ConclusionsHPV positive HNSCC patients display improved outcomes with PD-1/PD-L1 axis blockade as compared to HPV negative HNSCC patients. These improved outcomes are likely driven to a greater extent by anti-PD-L1 inhibitors. However, randomized controlled trials with greater numbers of patients are needed for validation of these early findings.
Microfluidic Rapid Prototype Enzymatic Biofuel Cell Based on a Nanocomposite
Authors: Mashayekhi Mazar Fariba , Alijanianzadeh Mahdi , Molaei Rad Ahmad , Heydari Payam 
Published: April 2021

Here, a low-cost glucose/O2 Y-shaped microfluidic biofuel cell was developed using a printed circuit board for microelectrode construction. A double-side tape based on the pressure-sensitive adhesive was used for microchannel fabrication. A nanocomposite that consisted of reduced graphene oxide gold nanoparticles (AuNPs), and poly neutral red connected to enzymes was applied on the copper electrode surface. The Aspergillus niger glucose oxidase enzyme and Mytheliophthora thermophile laccase were used to prepare the modified anodic and cathodic electrodes. Different procedures such as cyclic voltammetry scanning electron microscope coupled with energy-dispersive x-ray spectroscopy (EDX), and atomic force microscopy were used to scan the modified electrodes. SEM/EDX microanalysis displayed the structural and morphological properties of the proposed nanocomposite. The biofuel cell performance demonstrated a maximum power density of 36 μW cm−2, an open-circuit voltage of 0.5 V, and a flow rate of 50 μl min−1. The proposed rapid technique with RGO/AuNPs/PNR bioelectrodes is a good approach for finding low-cost microfluidic biofuel cells.
In vivo Confocal Microscopic Evaluation of Corneal Dendritic Cell Density and Subbasal Nerve Parameters in Dry Eye Patients: A Systematic Review and Meta-analysis
Authors: Xu Jing , Chen Peng , Yu Chaoqun , Liu Yaning , Hu Shaohua , Di Guohu 
Published: April 2021

Purpose: To conduct a systematic review and meta-analysis of the available research on evaluating changes in corneal dendritic cell density (CDCD) and the main subbasal nerve parameters (SNPs) on the ocular surface and assessing the diagnostic performance of in vivo confocal microscopy in patients with dry eye disease.Methods: A computerized systematic review of literature published in PUBMED, EMBASE, Web of Science, Scopus, and the Cochrane Central Register of Controlled Trials until May 8, 2020 was performed. All statistical analyses were conducted in RevMan V.5.3 software. The weighted mean differences (WMDs) and standardized mean differences (SMDs) with 95% confidence intervals (CI) between dry eye patients and healthy subjects were presented as results.Results: A total of 11 studies with 755 participants were recruited, and 931 eyes were included in this meta-analysis. However, not all studies reported both CDCD and SNPs. CDCD in the central cornea was higher (WMD = 51.06, 95% CI = 39.42–62.71), while corneal nerve fiber density (CNFD) and corneal nerve fiber length (CNFL) were lower (WMD = −7.96, 95% CI = −12.12 to −3.81; SMD = −2.30, 95%CI = −3.26 to −1.35) in dry eye patients in comparison with the corresponding values in healthy controls (all p &lt; 0.00001).Conclusion: Taken together, while CNFD and CNFL were lower in dry eye patients, central CDCD showed a significant increase in these patients in comparison with the corresponding values in healthy controls.
Weak Handgrip at Index Admission for Acute Exacerbation of COPD Predicts All-Cause 30-Day Readmission
Authors: Witt Leah J. , Spacht W. Alexandra , Carey Kyle A. , Arora Vineet M. , White Steven R. , Huisingh-Scheetz Megan , Press Valerie G. 
Published: April 2021

Rationale: Identifying patients hospitalized for acute exacerbations of COPD (AECOPD) who are at high risk for readmission is challenging. Traditional markers of disease severity such as pulmonary function have limited utility in predicting readmission. Handgrip strength, a component of the physical frailty phenotype, may be a simple tool to help predict readmission.Objective(s): To investigate if handgrip strength, a component of the physical frailty phenotype and surrogate for weakness, is a predictive biomarker of COPD readmission.Methods: This was a prospective, observational study of patients admitted to the inpatient general medicine unit at the University of Chicago Medicine, US. This study evaluated age, sex, ethnicity, degree of obstructive lung disease by spirometry (FEV1 percent predicted), and physical frailty phenotype (components include handgrip strength and walk speed). The primary outcome was all-cause hospital readmission within 30 days of discharge.Results: Of 381 eligible patients with AECOPD, 70 participants agreed to consent to participate in this study. Twelve participants (17%) were readmitted within 30 days of discharge. Weak grip at index hospitalization, defined as grip strength lower than previously established cut-points for sex and body mass index (BMI), was predictive of readmission (OR 11.2, 95% CI 1.3, 93.2, p = 0.03). Degree of airway obstruction (FEV1 percent predicted) did not predict readmission (OR 1.0, 95% CI 0.95, 1.1, p = 0.7). No non-frail patients were readmitted.Conclusions: At a single academic center weak grip strength was associated with increased 30-day readmission. Future studies should investigate whether geriatric measures can help risk-stratify patients for likelihood of readmission after admission for AECOPD.
Neuroskeletal Effects of Chronic Bioelectric Nerve Stimulation in Health and Diabetes
Authors: Beeve Alec T. , Shen Ivana , Zhang Xiao , Magee Kristann , Yan Ying , MacEwan Matthew R. , Scheller Erica L. 
Published: April 2021

Background/AimsBioelectric nerve stimulation (eStim) is an emerging clinical paradigm that can promote nerve regeneration after trauma, including within the context of diabetes. However, its ability to prevent the onset of diabetic peripheral neuropathy (DPN) has not yet been evaluated. Beyond the nerve itself, DPN has emerged as a potential contributor to sarcopenia and bone disease; thus, we hypothesized that eStim could serve as a strategy to simultaneously promote neural and musculoskeletal health in diabetes.MethodsTo address this question, an eStim paradigm pre-optimized to promote nerve regeneration was applied to the sciatic nerve, which directly innervates the tibia and lower limb, for 8 weeks in control and streptozotocin-induced type 1 diabetic (T1D) rats. Metabolic, gait, nerve and bone assessments were used to evaluate the progression of diabetes and the effect of sciatic nerve eStim on neuropathy and musculoskeletal disease, while also considering the effects of cuff placement and chronic eStim in otherwise healthy animals.ResultsRats with T1D exhibited increased mechanical allodynia in the hindpaw, reduced muscle mass, decreased cortical and cancellous bone volume fraction (BVF), reduced cortical bone tissue mineral density (TMD), and decreased bone marrow adiposity. Type 1 diabetes also had an independent effect on gait. Placement of the cuff electrode alone resulted in altered gait patterns and unilateral reductions in tibia length, cortical BVF, and bone marrow adiposity. Alterations in gait patterns were restored by eStim and tibial lengthening was favored unilaterally; however, eStim did not prevent T1D-induced changes in muscle, bone, marrow adiposity or mechanical sensitivity. Beyond this, chronic eStim resulted in an independent, bilateral reduction in cortical TMD.ConclusionOverall, these results provide new insight into the pathogenesis of diabetic neuroskeletal disease and its regulation by eStim. Though eStim did not prevent neural or musculoskeletal complications in T1D, our results demonstrate that clinical applications of peripheral neuromodulation ought to consider the impact of device placement and eStim on long-term skeletal health in both healthy individuals and those with metabolic disease. This includes monitoring for compounded bone loss to prevent unintended consequences including decreased bone mineral density and increased fracture risk.
Attitudes and Perceptions of Telemedicine in Response to the COVID-19 Pandemic: A Survey of Naïve Healthcare Providers
Authors: Schinasi Dana A. , Foster Carolyn C. , Bohling M. Katie , Barrera Leonardo , Macy Michelle L. 
Published: April 2021

Introduction: Expansion of telemedicine enabled healthcare access during the COVID-19 pandemic. In response to in-person visit restrictions, our institution trained &gt;1,000 clinicians in telemedicine. Little is known about telemedicine-naïve pediatric healthcare provider's perceptions as they adopted telemedicine practice.Methods: We conducted a cross-sectional survey of clinicians after expanding telemedicine practice at an independent children's hospital. The survey assessed experience with, concerns about, and intentions to continue telemedicine. Outpatient providers were included if they were first trained for telemedicine in response to COVID-19 and conducted at least one video visit, 3/21/2020–6/30/2020. Descriptive statistics were calculated; perceptions were compared across telemedicine activity level quartiles (based on proportions of visits delivered by video in June 2020) using Fisher's exact tests.Results: Of 609 survey responses, 305 (50.1%) met inclusion criteria, representing various roles and disciplines. Over half (54.1%) conducted &gt;20 video visits 3/21/2020–6/30/2020. More than 75% of providers found telemedicine easy to learn. Providers with greater proportions of video visits in a typical week in June reported greater ease of incorporating telemedicine into clinical practice and greater intention to continue telemedicine practice in 6 months. Nearly all providers endorsed concerns. Patient care experiences reinforced technology-related concerns and alleviated liability and privacy concerns. Payer reimbursement was the leading influencer of anticipated future use of telemedicine.Discussion: Providers who conducted more telemedicine encounters reported greater ease of incorporating telemedicine into practice. Provider concerns were influenced by patient care experiences. Targeted training and quality improvement strategies are needed to sustain a robust post-pandemic telemedicine program.
Interdisciplinary Approaches Suggested for Children With Multiple Hospital Referrals Presenting With Non-specific Conditions
Authors: Elgen Irene , Lygre Ragnhild , Greve Gottfried , Griffiths Silja , Heggestad Torhild 
Published: April 2021

Aims: To describe the care patterns of patients with repeated referrals to both mental and somatic specialist healthcare, and to study their diagnostic processes.Methods: In a previous register study patients aged 6–12 years referred to Haukeland University Hospital from 2013 to 2015, we found 922 children with at least three referrals including both somatic and mental health services. Of these, more than one in four (250) were randomly selected and observed from their first hospital episode ever and further after inclusion followed during their next three referrals or until July 2017. Data on referral patterns and diagnostics were collected from patient hospital records.Results: Mean number of referrals was 6.5 prior to inclusion and 4.2 in the follow-up period. At the end of the study period 15% of patients still had a non-specific diagnosis. During the follow-up period, more than half of the children were again referred across the border between somatic and mental healthcare.Conclusion: Very complex care patterns were found for these patients, who were repeatedly being referred and “crossing over” between mental and somatic healthcare. This indicates a need for more interdisciplinary-based approaches both within specialist care and between different care levels to broaden the perspective and achieve shorter time lag before reaching a diagnostic conclusion.Trial Registration: Data was obtained from Haukeland university hospital the patient registry system No. 2017/12470. Start of registration was April 1th 2017 and patients included was from 2013 to 15.
Serum Creatinine-to-Cystatin C Ratio in the Progression Monitoring of Non-alcoholic Fatty Liver Disease
Authors: Li Shaobo , Lu Jing , Gu Geng , Bai Wenkun , Ye Yafen , Bao Yuqian , Yu Haoyong , Han Junfeng 
Published: April 2021

BackgroundThe simultaneous assessment of visceral adiposity and muscle mass might be useful to monitor the risk of non-alcoholic fatty liver disease (NAFLD) progression in large population. We aimed to investigate the value of serum creatinine-to-cystatin C ratio (CCR) in evaluating these two parameters and predicting liver steatosis and fibrosis.Methods154 overweight/obese inpatients (49 males, 105 females) scheduled for bariatric surgery and 49 non-overweight/obese volunteers (18 males, 31 females) responded to the hospital advertisement were involved in the cross-sectional study. Liver steatosis and fibrosis were diagnosed with transient elastography (TE). The psoas muscle area (PMA) and visceral fat area (VFA) were measured using magnetic resonance imaging.ResultsThe body mass index, insulin resistance, and lipid profiles showed significant differences between the CCR tertiles. Multiple regression analyses revealed that the CCR was significantly associated with the controlled attenuation parameter (β = −0.30, P = 0.006 in males; β = −0.19, P = 0.017 in females) and liver stiffness measurements in males (β = −0.246, P = 0.044). A low CCR was associated with moderate-to-severe steatosis (P &lt; 0.001), significant liver fibrosis (P &lt; 0.01), and excellent predictive power for these two conditions (P &lt; 0.01). The CCR had a negative correlation with the VFA/PMA ratio (r = −0.584, P &lt; 0.001 in males; r = −0.569, P &lt; 0.001 in females).ConclusionsThe CCR is a serum marker for muscle-adjusted visceral fat mass, and a low CCR is associated with an increased risk of progressive NAFLD.
Adding Life to Their Years: The Current State of Pediatric Palliative Care in CKD
Authors: House Taylor R. , Wightman Aaron 
Published: April 2021

Abstract
Despite continued advances in medical treatment, pediatric CKD remains an unremitting, burdensome condition characterized by decreased quality of life and earlier death. These burdens underscore the need for integration of pediatric palliative care (PPC) into nephrology practice. PPC is an evolving field that strives to (1) relieve physical, psychologic, social, practical, and existential suffering; (2) improve quality of life; (3) facilitate decision making; and (4) assist with care coordination in children with life-threatening or life-shortening conditions. Integration of palliative care into routine care has already begun for adults with kidney disease and children with other chronic diseases; however, similar integration has not occurred in pediatric nephrology. This review serves to provide a comprehensive definition of PPC, highlight the unmet need in pediatric nephrology and current integration efforts, discuss the state of palliative care in adult nephrology and analogous chronic pediatric disease states, and introduce future opportunities for study.