bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrahigh‐Gain Organic Electrochemical Transistor Chemosensors Based on Self‐Curled Nanomembranes
Authors: Ferro Letícia M. M. , Merces Leandro , de Camargo Davi H. S. , Bof Bufon Carlos C. 
Published: June 2021

AbstractOrganic electrochemical transistors (OECTs) are technologically relevant devices presenting high susceptibility to physical stimulus, chemical functionalization, and shape changes—jointly to versatility and low production costs. The OECT capability of liquid‐gating addresses both electrochemical sensing and signal amplification within a single integrated device unit. However, given the organic semiconductor time‐consuming doping process and their usual low field‐effect mobility, OECTs are frequently considered low‐end category devices. Toward high‐performance OECTs, microtubular electrochemical devices based on strain‐engineering are presented here by taking advantage of the exclusive shape features of self‐curled nanomembranes. Such novel OECTs outperform the state‐of‐the‐art organic liquid‐gated transistors, reaching lower operating voltage, improved ion doping, and a signal amplification with a >104 intrinsic gain. The multipurpose OECT concept is validated with different electrolytes and distinct nanometer‐thick molecular films, namely, phthalocyanine and thiophene derivatives. The OECTs are also applied as transducers to detect a biomarker related to neurological diseases, the neurotransmitter dopamine. The self‐curled OECTs update the premises of electrochemical energy conversion in liquid‐gated transistors, yielding a substantial performance improvement and new chemical sensing capabilities within picoliter sampling volumes.
An Environmental Perception Self‐Adaptive Discolorable Hydrogel Film toward Sensing and Display
Authors: Xue Jingze , Yao Mengnan , Wang Guoyong , Wang Zuankai , Shen Liang , Liu Qingping , Liu Yan 
Published: June 2021

AbstractVision perception, especially color change, is the most direct and convenient way of feedback among numerous information recognition modes. Because of unique discoloration property upon stimulation, photonic crystals have attracted wide attention. Herein, with a facile UV polymerization process under the magnetic field, a sensitive photonic hydrogel film with vivid structural color is made. The structural color comes from the 1D chain‐like structures assembled by the carbon‐encapsulated Fe3O4 colloidal nanocrystal clusters (Fe3O4@CNCs), which are embedded in the flexible hydrogel matrix. The hydrogel can adapt its size to the environment, resulting in the regulation of intergranular distance and apparent color variation. Thus, a hydrogel film with humidity, ion concentration, and stress responsivity can be obtained, showing high sensitivity, stability, and full reversibility in a wide range of visible spectrum. It can be designed as a reusable display board or applied to colorimetric measurements similar to pH test paper. Innovatively, the hydrogel film is integrated as back reflectors to improve the efficiency of semitransparent polymer solar cells while protecting devices. This structural color hydrogel film makes it easier to recognize environmental dynamic changes and provide a wider application prospect in optics devices, sensing, display, and diagnostics.
A general framework and optimization models for the scheduling of continuous chemical processes
Authors: Wu Yaqing , Maravelias Christos T. 
Published: June 2021

AbstractWe present a framework for the formulation and solution of continuous process scheduling problems. We focus on modeling transient operations such as startups, shutdowns, and transitions between steady states. First, we show how the concept of processing tasks can be generalized to represent continuous processes, including their transient operations. Second, we discuss how to systematically calculate the parameters describing material consumption/production and utility consumption during transient operations. Finally, we present new mixed‐integer linear programming formulations for the scheduling of continuous chemical production.
Central compartment atopic disease: outcomes compared with other subtypes of chronic rhinosinusitis with nasal polyps
Authors: Steehler Andrew J. , Vuncannon Jackson R. , Wise Sarah K. , DelGaudio John M. 
Published: June 2021

AbstractBackgroundCentral compartment atopic disease (CCAD) is a variant of chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) characterized by polypoid changes of the superior nasal septum, middle (MT), and/or superior turbinates (ST). This study evaluates surgical outcomes in patients with CCAD compared with other CRSwNP subtypes.MethodsRetrospective analysis was performed at Emory University from May 2012 to November 2019. Patients undergoing primary endoscopic sinus surgery (ESS) for CCAD, aspirin‐exacerbated respiratory disease (AERD), allergic fungal rhinosinusitis (AFRS), and CRSwNP not otherwise specified (CRSwNP NOS) were included consecutively, beginning with the earliest date of CCAD patient. Outcome measures included polyp recurrence, revision ESS, oral steroid use, and oral antibiotic use. Pearson chi‐square and univariate analysis of variance (ANOVA) were performed for group comparisons.ResultsData was collected for 132 patients (CCAD = 38, AERD = 20, AFRS = 37, CRSwNP NOS = 37; 58 females, mean age 42.9 years [range, 13–85 years]). CCAD patients demonstrated polyp recurrence less frequently than expected, whereas AFRS patients had polyp recurrence more frequently than expected (p = 0.003; phi 0.32). CCAD patients underwent revision ESS less frequently than expected; AFRS and CRSwNP NOS underwent revision ESS more frequently than expected (p = 0.03; phi 0.26). CRSwNP NOS patients received more total antibiotic courses than those with CCAD (p = 0.01; eta‐squared 0.09) and more courses of antibiotics per month than those with AFRS (p = 0.03; eta‐squared 0.07). There was no significant difference in follow‐up measures across groups (number of visits, total months, or visits per month).ConclusionRates of polyp recurrence and revision ESS were significantly lower in CCAD patients compared with patients with other CRSwNP subtypes, suggesting durable benefit of ESS and postoperative medical therapy in CCAD patients.
The GSDMB rs7216389 SNP is associated with chronic rhinosinusitis in a multi‐institutional cohort
Authors: Zack Dana E. , Stern Debra A. , Willis Amanda L. , Kim Alexander S. , Mansfield Corinne J. , Reed Danielle R. , Brooks Steven G. , Adappa Nithin D. , Palmer James N. , Cohen Noam A. , Chiu Alexander G. , Song Brian H. , Le Chris H. , Chang Eugene H. 
Published: June 2021

AbstractBackgroundChronic rhinosinusitis (CRS) is a multifactorial disease with a high co‐occurrence with asthma. In this multicohort study, we tested whether single nucleotide polymorphisms (SNPs) associated with childhood asthma and rhinovirus (RV)‐associated disease are related to an increased susceptibility to adult CRS in a multicohort retrospective case‐control study.MethodsParticipants at two tertiary academic rhinology centers, University of Arizona (UofA) and University of Pennsylvania (UPenn) were recruited. Cases were defined as those with physician diagnosed CRS (UofA, n = 149; UPenn, n = 250), and healthy controls were those without CRS (UofA, n = 66; UPenn, n = 275). Genomic DNA was screened for the GSDMB rs7216389 SNP and CDHR3 rs6967330 SNP. Gene dosage, or the number of combined risk alleles in a single subject was calculated. Meta‐analysis of the association between GSDMB or CDHR3 genotypes and CRS was performed and additive gene dosage effect for each population calculated using p for trend.ResultsA meta‐analysis revealed a combined increased risk for CRS in subjects with the GSDMB rs7216389 SNP (odds ratio [OR] 1.40; 95% confidence interval [CI], 1.16–1.76; p = 0.004). Both the UofA (OR 1.73; 95% CI, 1.23–2.43; p = 0.002) and UPenn (OR 1.27; 95% CI, 1.02–1.58; p = 0.035) populations showed a significant positive association between the number of combined risk alleles of GSDMB rs7216389 SNP and CDHR3 rs6967330 SNP and risk for CRS.ConclusionCarriers of the GSDMB rs7216389 SNP and CDHR3 rs6967330 SNP are at increased susceptibility for CRS. These data suggest that therapeutic approaches to target aberrant responses to RV infection may play a role in the treatment of unified airway disease.
Fabrication of an antifoulingGO‐TiO2/PESultrafiltration membrane
Authors: Wang Wei , Shi Ya Ping , Zhang Peng , Zhang Zhi Chao , Xu Xin 
Published: June 2021

AbstractPES ultrafiltration membrane is widely used in various fields due to its high‐filtration efficiency. However, due to its hydrophobicity, PES ultrafiltration membrane has poor antifouling performance, this reduced service life and increased industrial cost. Blending is a common method in ultrafiltration membrane hydrophilic modification. Adding a small amount of inorganic nanoparticles into the polymer membrane can improve the properties of the polymer membrane. However, nanoparticles are not uniformly dispersed in polymer membrane, which hindering the modification ability of nanoparticles to ultrafiltration membrane. In this paper, GO‐TiO2materials were prepared by hydrothermal method, and GO‐TiO2/PES blended ultrafiltration membranes were fabricated by nonsolvent induced phase separation (NIPs). The experimental results show that GO‐TiO2disperse uniformly in GO‐TiO2/PES ultrafiltration membrane, which greatly improved the antifouling performance of the membrane. When the addition amount of GO‐TiO2is 0.6%, the water flux of membrane reaches 194.5 (L m−2 h−1), and the rejection rate of BSA reaches 89.4%. After three pollutions‐cycles, the flux recovery rate of the membrane is 90.2%.
Combined effect of transglutaminase and phenolic extract of Spirulina platensis in films based on starch and gelatin recovered from chrome III tanned leather waste
Authors: Rosseto Marieli , Rigueto Cesar Vinicius Toniciolli , Krein Daniela Dal Castel , Massuda Lillian Avila , Balbé Naiana Pereira , Colla Luciane Maria , Dettmer Aline 
Published: June 2021

AbstractThis study aimed to enhance the properties of films produced from corn starch and gelatin recovered from chrome (III) tanned leather waste (CTLW) through the addition of transglutaminase enzyme (TGase) and phenolic extracts from Spirulina platensis (PESP). Mechanical, chemical, physical, and biological properties were analyzed and compared with control films elaborated in the same conditions but with commercial gelatin (COM). The possibility of applying the film as soil cover was analyzed through its degradation when exposed to the surface of a garden soil for a period of 60 days. The TGase caused a reduction of 50% in solubility in water, and 2% in the water vapor permeability (PWV), and PESP caused a reduction of 17% in solubility and 15% in PWV. The combined effect of TGase and PESP was a 60% reduction in solubility, 75% reduction in PWV, inhibition of contamination by Aspergillus niger, and reduction of film degradation on soil covering, evidenced by stability analysis using Fourier transform infrared (FTIR) spectrometry. The combined effect of TGase with PESP led to an improvement in the characteristics of the film produced with CTLW gelatin, rendering its application possible due to a higher lifespan, contributing to environmental sustainability and diminishing leather waste disposal at landfills. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd
Scale‐up of an intensified bioprocess for the expansion of bovine adipose‐derived stem cells (bASCs) in stirred tank bioreactors
Authors: Hanga Mariana Petronela , de la Raga Fritz Anthony , Moutsatsou Panagiota , Hewitt Christopher J. , Nienow Alvin W. , Wall Ivan 
Published: June 2021

AbstractCultivated meat is an emerging field, aiming to establish the production of animal tissue for human consumption in an in vitro environment, eliminating the need to raise and slaughter animals for their meat. To realise this, the expansion of primary cells in a bioreactor is needed to achieve the high cell numbers required. The aim of this study was to develop a scalable, microcarrier based, intensified bioprocess for the expansion of bovine adipose‐derived stem cells as precursors of fat and muscle tissue. The intensified bioprocess development was carried out initially in spinner flasks of different sizes and then translated to fully controlled litre scale benchtop bioreactors. Bioprocess intensification was achieved by utilising the previously demonstrated bead‐to‐bead transfer phenomenon and through the combined addition of microcarrier and medium to double the existing surface area and working volume in the bioreactor. Choosing the optimal time point for the additions was critical in enhancing the cell expansion. A significant fold increase of 114.19 ± 1.07 was obtained at the litre scale in the intensified bioprocess compared to the baseline (**p < .005). The quality of the cells was evaluated pre‐ and post‐expansion and the cells were found to maintain their phenotype and differentiation capacity.
Computed tomography derived predictors of permanent pacemaker implantation after transcatheter aortic valve replacement: A meta‐analysis
Authors: Maier Oliver , Piayda Kerstin , Afzal Shazia , Polzin Amin , Westenfeld Ralf , Jung Christian , Zeus Tobias , Antoch Gerald , Kelm Malte , Veulemans Verena 
Published: June 2021

AbstractObjectivesThis meta‐analysis sought to assess predictors of permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement (TAVR) with focus on preprocedural multi‐slice computed tomography (MSCT) derived data.BackgroundTranscatheter aortic valve replacement (TAVR) has expanded to a well‐established treatment for severe symptomatic aortic stenosis at high and intermediate surgical risk. PPI after TAVR remains one of the most frequent procedure‐related complications and appears to be influenced by several factors.MethodsThe authors conducted a literature search in PubMed/MEDLINE and EMBASE databases to identify studies that investigated preprocedural MSCT data and the rate of PPI following TAVR with new‐generation devices.ResultsTen observational studies (n = 2707) met inclusion criteria for the final analysis. PPI was performed in 387 patients (14.3%) after TAVR. Patients requiring PPI had a larger annulus perimeter (MD: 1.66 mm; p < .001) and a shorter membranous septum length (MD: −1.1 mm; p < .05). Concerning calcification distribution, patients with requirement for new pacemaker implantation showed increased calcification of the left coronary cusp (MD: 47.6 mm3; p < .001), and the total left ventricular outflow tract (MD: 24.42 mm3; p < .01). Lower implantation depth (MD: 0.95 mm; p < .05) and oversizing (MD: 1.52%; p < .05) were procedural predictors of PPI following TAVR.ConclusionsBesides the well‐known impact of electrocardiographic and procedure‐related factors on conduction disturbances, MSCT derived distribution of the aortic valve and left ventricular outflow tract calcification, as well as membranous septum length, are associated with an increased risk of PPI following TAVR.
Copper‐Photocatalyzed Hydrosilylation of Alkynes and Alkenes under Continuous Flow
Authors: Zhong Mingbing , Pannecoucke Xavier , Jubault Philippe , Poisson Thomas 
Published: June 2021

AbstractHerein, the photocatalytic hydrosilylation of alkynes and alkenes under continuous flow conditions is described. By using 0.2 mol % of the developed [Cu(dmp)(XantphosTEPD)]PF6 under blue LEDs irradiation, a large panel of alkenes and alkynes was hydrosilylated in good to excellent yields with a large functional group tolerance. The mechanism of the reaction was studied, and a plausible scenario was suggested.
A cost‐utility analysis comparing CT surveillance, PET‐CT surveillance, and planned postradiation neck dissection for advanced nodal HPV‐positive oropharyngeal cancer
Authors: Fu Terence S. , Scheffler Patrick , Forner David , Noel Christopher W. , Huang Shao Hui , Gilbert Ralph W. , Goldstein David P. , O’Sullivan Brian , Mehanna Hisham M. , Waldron John , de Almeida John R. 
Published: June 2021

BackgroundThe cost utility of image‐guided surveillance using computed tomography (CT) and positron emission tomography (PET)‐CT to planned postradiation neck dissection (PRND) was compared for the management of advanced nodal human papillomavirus‐positive oropharyngeal cancer following chemoradiation.MethodsA universal payer perspective was adopted. A Markov model was designed to simulate four treatment approaches with 3‐month cycles over a lifetime horizon: 1) CT surveillance, 2) standard PET‐CT surveillance, 3) a novel PET‐CT approach with repeat PET at 6 months postchemoradiation for equivocal responders, and 4) PRND. Parameters including probabilities of CT nodal progression/resolution, PET avidity, recurrence, and survival were obtained from the literature. Costs were reported in 2019 Canadian dollars and utilities were expressed in quality‐adjusted life years (QALYs). Deterministic and probabilistic sensitivity analyses were performed to evaluate model uncertainty.ResultsPET‐CT surveillance dominated CT surveillance and PRND in the base case scenario, and the novel PET‐CT approach was the most cost‐effective strategy across a wide range of variables tested in one‐way sensitivity analysis. On probabilistic sensitivity analysis, novel PET‐CT surveillance was the most cost‐effective strategy in 78.1% of model iterations at a willingness‐to‐pay of $50,000/QALYs. Novel PET‐CT surveillance resulted in a 49% lower rate of neck dissection compared with traditional PET‐CT, and yielded an incremental benefit of 0.14 QALYs with average cost savings of $1309.ConclusionsImage‐guided surveillance including PET‐CT and CT are more cost effective than PRND. The novel PET‐CT approach with repeat PET for equivocal responders was the dominant strategy and yielded both higher benefit and lower costs compared with standard PET‐CT surveillance.
Is Milan for kids?: The Milan System for Reporting Salivary Gland Cytology in pediatric patients at an academic children's hospital with cytologic‐histologic correlation
Authors: Satturwar Swati P. , Fuller Maren Y. , Monaco Sara E. 
Published: June 2021

BackgroundThe Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) provides a useful framework for the diagnosis of salivary gland fine‐needle aspiration (FNA) biopsies. In this study, the MSRSGC was applied to salivary gland FNAs in pediatric patients to assess its usefulness and look at pitfalls.MethodsThe laboratory information system was queried over a 15‐year period for all salivary gland FNAs in patients 18 years old or younger. Patient demographics, FNA diagnosis categorized according to the MSRSGC, and follow‐up surgical pathology diagnoses were examined and correlated.ResultsThirty‐two cases were identified, with an average age of 12 years (range, 0.6‐18 years). A majority of the cases (84.4%) were from the parotid region. Twenty of 32 cases (62.5%) had follow‐up resection. MSRSGC recategorization diagnoses of the 32 FNA cases were 34% benign neoplasm, 31% nonneoplastic, 16% nondiagnostic, 9% atypia of undetermined significance, 3% salivary neoplasm of uncertain malignant potential, 3% suspicious for malignancy, and 3% malignant. Overall, the sensitivity and specificity were 100% and 80%, respectively. On follow‐up resection, 55% were neoplastic: pleomorphic adenomas (n = 6; 55%), pilomatricoma (n = 3; 28%), mucoepidermoid carcinoma (n = 1; 9%), schwannoma (n = 1; 9%), and myofibroma (n = 1; 9%).ConclusionsThe MSRSGC performed fairly well in the pediatric population with a low overall risk of malignancy (6%) and high sensitivity. Although the majority of pediatric salivary gland FNAs were benign, 55% of resected cases were positive for a neoplasm, with benign neoplasms outnumbering malignancy. Challenging entities included inflammatory conditions, like immunoglobulin G4‐related sialadenitis, and skin and soft tissue lesions near the salivary gland.
Effects of pre‐analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and neurodegeneration
Authors: Ashton Nicholas J. , Suárez‐Calvet Marc , Karikari Thomas K. , Lantero‐Rodriguez Juan , Snellman Anniina , Sauer Mathias , Simrén Joel , Minguillon Carolina , Fauria Karine , Blennow Kaj , Zetterberg Henrik 
Published: June 2021

AbstractIntroductionWe tested how tube types (ethylenediaminetetraacetic acid [EDTA], serum, lithium heparin [LiHep], and citrate) and freeze–thaw cycles affect levels of blood biomarkers for Alzheimer's disease (AD) pathophysiology, glial activation, and neuronal injury.MethodsAmyloid beta (Aβ)42, Aβ40, phosphorylated tau181 (p‐tau181), glial fibrillary acidic protein, total tau (t‐tau), neurofilament light, and phosphorylated neurofilament heavy protein were measured using single molecule arrays.ResultsLiHep demonstrated the highest mean value for all biomarkers. Tube types were highly correlated for most biomarkers (r > 0.95) but gave significantly different absolute concentrations. Weaker correlations between tube types were found for Aβ42/40 (r = 0.63–0.86) and serum t‐tau (r = 0.46–0.64). Freeze–thaw cycles highly influenced levels of serum Aβ and t‐tau (P < .0001), and minor decreases in EDTA Aβ40 and EDTA p‐tau181 were found after freeze–thaw cycle 4 (P < .05).DiscussionThe same tube type should be used in research studies on blood biomarkers. Individual concentration cut‐offs are needed for each tube type in all tested biomarkers despite being highly correlated. Serum should be avoided for Aβ42, Aβ40, and t‐tau. Freeze–thaw cycles > 3 should be avoided for p‐tau181.
Rhodium Encapsulated within Silicalite‐1 Zeolite as Highly Efficient Catalyst for Nitrous Oxide Decomposition: From Single Atoms to Nanoclusters and Nanoparticles
Authors: Wang Shiwei , Yan Bo , Chai Juan , Li Tianhao , Yu Hongbo , Li Tong , Cao Peng , Yang Fan , Yuan Xuemin , Yin Hongfeng 
Published: June 2021

AbstractThe size of metal species plays a pivotal role in governing catalytic performance of supported metal catalysts. In this work, a series of Rh encapsulated within silicalite‐1 catalysts with different sizes were prepared by one‐pot hydrothermal method and employed to catalyze the decomposition of N2O. Detailed structure determinations by HAADF‐STEM, XPS and CO‐DRIFTS demonstrate that subtle modulation of the encapsulated Rh species were achieved easily from single‐atom to nanoclusters and nanoparticles by controlling the loading and reduction conditions of Rh. The turnover frequency (TOF) of N2O decomposition showed a typical volcano‐type dependence on Rh size. Kinetic studies revealed that this structure‐sensitive catalysis was related to the difference in N2O and O2 adsorption/desorption for various Rh species. Furthermore, a Rh@S‐1 catalyst with a proper Rh size (ca. 1.6 nm) was identified as the best‐performing catalyst with a maximum TOF (ca. 95 h−1), showing much superior activity than other reported Rh‐based catalysts.