bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence of hybridization between Yaqui catfish Ictalurus pricei (Rutter, 1896) and channel catfish Ictalurus punctatus (Rafinesque, 1818) in north‐west México revealed by analysis of mitochondrial and nuclear genes
Authors: Gutiérrez‐Barragán Alexsandre , García‐De León Francisco Javier , Varela‐Romero Alejandro , Ballesteros‐Córdova Carlos Alonso , Grijalva‐Chon José Manuel , De la Re‐Vega Enrique 
Published: September 2021

Abstract

The Yaqui catfish, Ictalurus pricei, is the only native ictalurid species described from north‐west México and south‐west USA. It is an endangered species owing to the decline and loss of most of its historical populations, mainly because of competition and hybridization with the non‐native channel catfish, Ictalurus punctatus. The Arroyo Cajón Bonito is one of the few remnant populations of Yaqui catfish in the Yaqui River basin, and it is threatened by the presence of channel catfish that escaped from private culture facilities.
Phylogenetic analysis of two mitochondrial and two nuclear genes was used to detect evidence of hybridization with channel catfish in a collection of 20 catfish from Arroyo Cajón Bonito. Fourteen putatively pure Yaqui catfishes, five hybrids and one channel catfish were detected.
This study further highlights hybridization between channel and Yaqui catfish as the main threat to the remaining Yaqui catfish populations. We recommend urgent evaluation of the remnant populations of native catfish elsewhere and their current conservation status.
Anuran development: A reinvestigation of the conus arteriosus and gill formation in Bufo bufo throughout metamorphosis using micro‐CT
Authors: Kraus Nina , Metscher Brian 
Published: September 2021

AbstractUsing high‐resolution X‐ray micro‐CT imaging of whole Bufo bufo specimens, we acquired detailed 3D descriptions of the changing morphology of the cardiac outflow structures, in particular the conus arteriosus through larval development and the transition. Previous findings regarding anuran conal structures were contradictory, depending on the specifics of the 2D imaging methods used by different authors. Our descriptions of conal morphology at different developmental stages show that early tadpoles initially only have one opening at the ventricular‐conal junction and only one cavum within their conus; however, the forming septum coni soon divides the conus into two chambers, the cavum pulmocutaneum and the cavum aorticum. This is accompanied by the development of a second small opening at the ventricular‐conal junction. The separated chambers continue into the aortic arches. Following the aortic arches into the area where gills will form, we describe how blood vessels associated with the external gills develop from vessels arising from the truncus arteriosus. The external gills soon undergo partial absorption. During the transition from external to internal gills, the gill filaments retreat asymmetrically into a gill chamber formed by a hyoidal cover contacting the animal's ventral side, leaving only a single opening on the animal's left side, the opercular spout. B. bufo retains its internal gills up to metamorphic climax, with the aortic arches arising from the conus arteriosus still leading into the gills. Our 3D image data are publicly available and will provide a sound morphological basis for future studies.
Suppressing Charge Disproportionation of MnO2 Cathodes in Rechargeable Zinc Ion Batteries via Cooperative Jahn‐Teller Distortion
Authors: Heo Jiyun , Chong Sanggyu , Kim Soohyun , Kim Riyul , Shin Kyungjae , Kim Jihan , Kim Hee‐Tak 
Published: September 2021

AbstractMnO2 is a promising candidate material as intercalative cathodes in rechargeable aqueous zinc ion batteries (ZIBs). It is renowned for its low cost, minimal toxicity, and high energy density; however, severe capacity fading from the dissolution of MnO2 remains a critical challenge that must be overcome to achieve improved cycling performance. In this study, surface coating of MnO2 with dicyandiamide is proposed as a method to significantly reduce the dissolution of MnO2 by addressing the fundamental cause of MnO2 dissolution, which is the charge disproportionation (CD) reaction of Mn3+. Experimental and computational methods are used to demonstrate that the surface coating triggers cooperative Jahn‐Teller distortion of Mn4+ to alleviate lattice distortion and impede the CD reaction. Thus, the cycling stability of MnO2 is significantly improved, exhibiting 170 % higher capacity in comparison with pristine MnO2 and 99.9 % coulombic efficiency under a 1C rate condition. Resolving the orbital degeneracy with surface modification will open a new and prospective path for superior cycling performance of MnO2‐based ZIBs.
Golgi stress response: A regulatory mechanism of Golgi function
Authors: Gao Jiayin , Gao Anbo , Liu Wei , Chen Linxi 
Published: September 2021

AbstractThe organelle of eukaryotes is a finely regulated system. Once disturbed, it activates the specific autoregulatory systems, namely, organelle autoregulation. Among which, the Golgi stress response accounts for one. When the abundance and capacity of the Golgi apparatus are insufficient compared with cellular demand, the Golgi stress response is activated to enhance the function of the Golgi apparatus. Although the molecular mechanism of the Golgi stress response has not been well characterized yet, it seems to be an important part of the mammalian stress response. In this review, we discuss the current status of research on the six pathways of the mammalian Golgi stress response (the TFE3, heat shock protein 47, CREB3, E26 transformation specific, proteoglycan, and mucin pathways), which regulate the general function of the Golgi apparatus, anti‐apoptosis, pro‐apoptosis, proteoglycan glycosylation, and mucin glycosylation, respectively.
Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect
Authors: Bagheri Mitra , Validi Majid , Gholipour Abolfazl , Makvandi Pooyan , Sharifi Esmaeel 
Published: September 2021

AbstractBacterial wound infection is one of the most common nosocomial infections. The unnecessary employment of antibiotics led to raising the growth of antibiotic‐resistant bacteria. Accordingly, alternative armaments capable of accelerating wound healing along with bactericidal effects are urgently needed. Considering this, we fabricated chitosan (CS)/polyethylene oxide (PEO) nanofibers armed with antibacterial silver and zinc oxide nanoparticles. The nanocomposites exhibited a high antioxidant effect and antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Besides, based on the results of the cell viability assays, the optimum concentration of ZnONPs and AgNPs in the nanofibrous mats is 0.2% w/v and 0.08% w/v respectively and had no cytotoxicity on fibroblast cells. The scaffold also showed good blood compatibility according to the effects of coagulation time. As well as significant fibroblast migration and proliferation on the wound margin, according to wound‐healing assay. All in all, the developed biocompatible, antioxidant, and antibacterial Ag‐ZnO NPs incorporated CS/PEO nanofibrous mats showed their potential as an effective wound dressing.
New NF‐κB Inhibitory Steroids from the Marine Sponge Dysidea avara Collected from the South China Sea
Authors: Zhao Lu , Zhang Li‐Ling , Miao Xian‐Xian , Li Jia‐Xin , Lin Hou‐Wen , Jiao Wei‐Hua 
Published: September 2021

AbstractChemical investigation of the marine sponge Dysidea avara, collected from the South China Sea, yielded 13 steroids, including nine new (1–9) and four known (10–13) ones. The new structures were elucidated as (3S,14R)‐3,14‐dihydroxycholesta‐5,8‐dien‐7‐one (1), (22E,24R)‐7α‐ethoxy‐5α,6α‐epoxyergosta‐8(14),22‐dien‐3β‐ol (2), 3β‐hydroxy‐7α‐ethoxy‐5α,6α‐epoxy‐8(14)‐cholestene (3), 3β,5α‐dihydroxy‐6α‐ethoxychofesta‐7,9(11)‐diene (4), 3β,5α‐dihydroxy‐6β‐ethoxycholest‐7‐ene (5), (22E,24R)‐24‐ethoxy‐3β,5α‐dihydroxy‐6β‐ethoxyergosta‐7,22‐diene (6), (22E)‐3β,5α‐dihydroxy‐6β‐ethoxycholesta‐7,22‐diene (7), 24‐ethoxy‐3β,5α‐dihydroxy‐6β‐ethoxycholest‐7‐ene (8 and 9), by extensive spectroscopic analyses, such as HR‐ESI‐MS, 1D and 2D NMR data. The absolute configuration of 1 was assigned by comparison the experimental ECD spectra with the calculated ones. Among the 13 metabolites, compounds 1, 4, 11, 12, and 13 showed NF‐κB inhibitory activities in human HER‐293 cells with IC50 values of 6.4, 18.7, 8.1, 9.6, and 7.5 μM, respectively. Preliminary structure−activity relationship analysis unveiled that the conjugated ketones or unsaturated double bonds might be the functional groups for the five active steroids.
Below the knee percutaneous transluminal angioplasty for claudicants: One vessel is enough to relieve symptoms
Authors: Stabile Eugenio , Esposito Giovanni 
Published: September 2021

Key Points
Among patients with lower extremities arterial disease (LEAD), treatment of below the arteries has been historically limited to the treatment of chronic limb‐threatening ischemia (CLTI), as recommended by available guidelines.
In this study, the authors provided new data on the role of different endovascular revascularization anatomical strategies of the below the knee (BTK) arteries adopted in claudicant LEAD patients.
The revascularization of the anterior tibial artery seems more effective for symptoms relieves than of the posterior territories and most of the adverse events occurred in the follow up period were target vessel revascularization, suggesting that revascularization of single vessel is enough to achieve clinical success.
Sn Doping on Ta2O5 Facilitates Glucose Isomerization for Enriched 5‐Hydroxymethylfurfural Production and its True Response Prediction using a Neural Network Model
Authors: Mahala Sangeeta , Arumugam Senthil M. , Kumar Sandeep , Singh Dalwinder , Sharma Shelja , Devi Bhawana , Yadav Sudesh K. , Elumalai Sasikumar 
Published: September 2021

AbstractHere, we describe the maximum production of 5‐HMF using glucose over Sn doped Ta2O5 in a binary solvent system. The analytical characterizations established that Sn4+ in the catalyst interacts with Ta2O5 and offers the Lewis acid sites favorable for glucose isomerization to fructose. Similarly, the Ta2O5 support offers both the Lewis and Brønsted acid sites to promote fructose dehydration to 5‐HMF. The catalyst provided favorable conditions for the sequential sugar(s) transformation, i. e., glucose isomerization followed by fructose dehydration, which resulted in a 5‐HMF yield as high as 57 % wt. and 80 % selectivity under modest reaction conditions in a water‐DMSO system using ST1 (1 % Sn on Ta2O5). The separate fructose to 5‐HMF conversion study verified the negligible influence of Sn on the dehydration reaction. Moreover, the catalyst's systematic sugar conversion enabled a >65 % fructose formation, which accounts for the enriched 5‐HMF synthesis. The neural network model best represented the 5‐HMF data (<4 % MAE for glucose and fructose conversions).
Alkane Production from Unsaturated Fatty Acids over Transition Metal‐Doped Pd Catalysts
Authors: Schipanskaya Elena O. , Stepacheva Antonina A. , Markova Mariia E. , Rud Daria V. , Nikoshvili Linda Zh. , Sidorov Alexander I. , Matveeva Valentina G. , Sulman Mikhail G. 
Published: September 2021

AbstractAlkane production from fatty acids and their derivatives can be considered one of the most‐studied processes. Such reactions as hydrogenation, hydrodeoxygenation, decarboxylation, and decarbonylation are the main routes for this process. The reaction pathway depends on the nature of the catalyst, the presence of hydrogen, and the hydrogen source. In this work, a mixture of unsaturated fatty acids (oleic and linoleic acids) was converted to alkanes (mainly heptadecane) in a hydrogen‐free atmosphere by using 2‐propanol as hydrogen donor. Transition metal doped Pd catalysts embedded on a porous organic support (hypercrosslinked polystyrene) were used as catalysts. A Pd‐Cu catalyst showed the highest effectiveness, allowing up to 99.9 mol % selectivity to heptadecane to be obtained. The process proceeds through fatty acid esterification, further hydrogenation of double bonds, and decarboxylation to form n‐heptadecane as main product.
Saturated Boronic Acids, Boronates, and Trifluoroborates: An Update on Their Synthetic and Medicinal Chemistry
Authors: Volochnyuk Dmitriy M. , Gorlova Alina O. , Grygorenko Oleksandr O. 
Published: September 2021

AbstractThis review discusses recent advances in the chemistry of saturated boronic acids, boronates, and trifluoroborates. Applications of the title compounds in the design of boron‐containing drugs are surveyed, with special emphasis on α‐amino boronic derivatives. A general overview of saturated boronic compounds as modern tools to construct C(sp3)−C and C(sp3)‐heteroatom bonds is given, including recent developments in the Suzuki‐Miyaura and Chan‐Lam cross‐couplings, single‐electron‐transfer processes including metallo‐ and organocatalytic photoredox reactions, and transformations of boron “ate” complexes. Finally, an attempt to summarize the current state of the art in the synthesis of saturated boronic acids, boronates, and trifluoroborates is made, with a brief mention of the “classical” methods (transmetallation of organolithium/magnesium reagents with boron species, anti‐Markovnikov hydroboration of alkenes, and the modification of alkenyl boron compounds) and a special focus on recent methodologies (boronation of alkyl (pseudo)halides, derivatives of carboxylic acids, alcohols, and primary amines, boronative C−H activation, novel approaches to alkene hydroboration, and 1,2‐metallate‐type rearrangements).
Visible‐Light Mediated Tryptophan Modification in Oligopeptides Employing Acylsilanes
Authors: Reimler Jannik , Studer Armido 
Published: September 2021

AbstractA method for the selective tryptophan modification and labelling of tryptophan‐containing peptides is described. Photoirradiation of acylsilanes generates reactive siloxycarbenes which undergo H−N‐insertion into the indole moiety of tryptophan to give stable silyl protected hemiaminals. This method is successfully applied to chemically modify various tryptophan containing oligopeptides. The method enables the selective introduction of alkynes to peptides that are eligible for further alkyne‐azide click chemistry. In addition, the dansyl fluorophore can be conjugated to a peptide using this approach.
Substance use and mental health burden in head and neck and other cancer survivors: A National Health Interview Survey analysis
Authors: Balachandra Sanjana , Eary Rebecca L. , Lee Rebecca , Wynings Erin M. , Sher David J. , Sura Teena , Liu Yulun , Tillman Brittny N. , Sumer Baran D. , Arnold Elizabeth Mayfield , Tiro Jasmin A. , Lee Simon C. , Day Andrew T. 
Published: September 2021

BackgroundTobacco dependence, alcohol abuse, depression, distress, and other adverse patient‐level influences are common in head and neck cancer (HNC) survivors. Their interrelatedness and precise burden in comparison with survivors of other cancers are poorly understood.MethodsNational Health Interview Survey data from 1997 to 2016 were pooled. The prevalence of adverse patient‐level influences among HNC survivors and matched survivors of other cancers were compared using descriptive statistics. Multivariable logistic regressions evaluating covariate associations with the primary study outcomes were performed. These included 1) current cigarette smoking and/or heavy alcohol use (>14 drinks per week) and 2) high mental health burden (severe psychological distress [Kessler Index ≥ 13] and/or frequent depressive/anxiety symptoms).ResultsIn all, 918 HNC survivors and 3672 matched survivors of other cancers were identified. Compared with other cancer survivors, more HNC survivors were current smokers and/or heavy drinkers (24.6% [95% CI, 21.5%‐27.7%] vs 18.0% [95% CI, 16.6%‐19.4%]) and exhibited a high mental health burden (18.6% [95% CI, 15.7%‐21.5%] vs 13.0% [95% CI, 11.7%‐14.3%]). In multivariable analyses, 1) a high mental health burden predicted for smoking and/or heavy drinking (odds ratio [OR], 1.4; 95% CI, 1.0‐1.9), and 2) current cigarette smoking predicted for a high mental health burden (OR, 1.7; 95% CI, 1.2‐2.3). Furthermore, nonpartnered marital status and uninsured/Medicaid insurance status were significantly associated with both cigarette smoking and/or heavy alcohol use (ORs, 1.9 [95% CI, 1.4‐2.5] and 1.5 [95% CI, 1.0‐2.1], respectively) and a high mental health burden (ORs, 1.4 [95% CI, 1.1 ‐1.8] and 3.0 [95% CI, 2.2‐4.2], respectively).ConclusionsStakeholders should allocate greater supportive care resources to HNC survivors. The interdependence of substance abuse, adverse mental health symptoms, and other adverse patient‐level influences requires development of novel, multimodal survivorship care interventions.
Caution! Fragile relationship: Effective responses to conflicts with in‐laws
Authors: Cheraghi Mona , Malekianjabali Mona 
Published: September 2021

AbstractExperiencing difficulties with in‐laws is a significant predictor of divorce in Iran. This research investigates the differences between how satisfied and dissatisfied spouses get along with their in‐laws, and how each group responds to in‐law conflicts. For this purpose, we conducted two studies. In a quantitative study, we compared the responses of two groups of people who were either satisfied (n = 167) or dissatisfied (n = 166) with their in‐law relationship, and how they responded to conflict situations. In the qualitative study, we interviewed 22 participants and asked them about conflicts with their in‐laws and responses to those conflicts. Results revealed significant differences between the methods used by satisfied and dissatisfied participants. Both studies showed that direct expression of annoyance is not an effective option in responding to in‐law conflicts. Findings led to an optimal model for responding to differences with in‐laws. The model has three stages: (a) the personal stage, (b) the inter‐couple stage, and (c) the response to the in‐law stage. It seems that when spouses are satisfied with in‐law relationships, they take a conservative approach when conflict arises. The model can be used in educational, preventive, and therapeutic interventions.
Proximal to distal grain‐size distribution of basin‐floor lobes: A study from the Battfjellet Formation, Central Tertiary Basin, Svalbard
Authors: Spychala Yvonne T. , Ramaaker Thymen A. B. , Eggenhuisen Joris T. , Grundvåg Sten‐Andreas , Pohl Florian , Wróblewska Sara 
Published: September 2021

AbstractThe grain‐size distribution of sediment particles is an important aspect of the architecture of submarine fans and lobes. It governs depositional sand quality and reflects distribution of particulate organic carbon and pollutants. Documenting the grain‐size distribution of these deep‐marine sedimentary bodies can also offer us an insight into the flows that deposited them. Submarine lobes are commonly assumed to linearly fine from an apex, meaning there should be a proportional relationship between grain size and distance from the lobe apex. However, not much detailed quantitative work has been done to test this hypothesis. Exposure of a 5 km long dip‐section of basin‐floor lobes in Clinoform 12, Battfjellet Formation, Spitsbergen, enable the study of basinward grain‐size evolution in lobe deposits. Furthermore, the dataset allows testing if there are any documentable grain‐size differences between lobe sub‐environments. For this purpose, the palaeogeography of Clinoform 12 was reconstructed and the youngest lobe, which was exposed in all collected logs, chosen to be evaluated for its grain‐size trends. Photographed thin sections of 66 rock samples were analysed to obtain quantitative grain‐size distributions. The results show that fining of lobe deposits occurs predominantly in the most proximal and most distal parts of the lobe, while the intermediate lobe, which is dominated by lobe off‐axis deposits, is characterised by a relatively consistent grain‐size range. Lobe sub‐environments show statistically distinct grain‐size distributions from lobe axis to lobe fringe. An explanation for these trends is the interplay of capacity and competence‐driven deposition with the grain‐size stratification of the flows. The outcomes of this study help to better understand the proximal to distal evolution of turbidity currents and their depositional patterns. They also provide important insights in reservoir potential of basin‐floor fans at lobe scale.
Psoriatic arthritis—What we know now?
Authors: Shah Rohan , Koschitzky Merav , Khattri Saakshi 
Published: September 2021

AbstractIntroductionOver the past decade, our understanding of psoriatic arthritis (PsA) as a chronic inflammatory condition with a heterogenous manifestation has vastly improved. A better understanding of pathophysiology, susceptibility, clinical features, and treatment have all warranted a comprehensive and organized review of this musculoskeletal disorder which continues to affect a growing population of the western world along with psoriasis patients.MethodsRelevant articles on PsA were retrieved through a selective search on PubMed.DiscussionBy acknowledging the present state of diagnostic methods and subsequent treatment strategies, clinicians will be more equipped to identify and treat this condition while also encouraging the importance of screening those who may be susceptible based on immune, environmental, and genetic factors. This article reviews the current knowledge of PsA and addresses the areas for future research.
Percutaneous edge‐to‐edge mitral valve repair for mitral regurgitation improves heart failure symptoms in heart failure with preserved ejection fraction patients
Authors: Gröger Matthias , Scheffler Jinny Karin , Schösser Florian , Schneider Leonhard Moritz , Rottbauer Wolfgang , Markovic Sinisa , Keßler Mirjam 
Published: September 2021

AbstractAimsTherapeutic options for patients with heart failure with preserved ejection fraction (HFpEF) are sparse. Mitral regurgitation (MR) is a common feature of HFpEF and worsens heart failure symptoms and prognosis. Our study examines the outcome of patients with preserved left ventricular ejection fraction (LVEF) and elevated left atrial (LAP) or left ventricular filling pressures (LVEDP), indicative of HFpEF, after undergoing percutaneous edge‐to‐edge mitral valve repair (pMVR) for moderate–severe MR.Methods and resultsTwo hundred eleven patients with preserved LVEF (>50%), who underwent pMVR, were dichotomized by LAP (< / ≥15 mmHg) and LVEDP (< / ≥16 mmHg). Forty‐nine per cent of patients showed elevated LAP, and LVEDP was elevated in 55%, both indicating HFpEF. Patients with elevated filling pressures featured typical clinical characteristics of HFpEF, higher N‐terminal pro‐brain natriuretic peptide levels (5544.9 pg/mL in high LAP group vs. 3071.7 pg/mL in normal LAP group, P = 0.06; 5061.0 pg/mL in high LVEDP group vs. 3230.3 pg/mL in normal LVEDP group, P = 0.08), and higher prevalence of pulmonary hypertension (mean pulmonary artery pressure 36.4 mmHg in high LAP group vs. 26.3 mmHg in normal LAP group, P < 0.001; 35.2 mmHg in high LVEDP group vs. 29.7 mmHg in normal LVEDP group, P = 0.004) and atrial fibrillation (78.8% in normal LAP group vs. 61.0% in high LAP group, P = 0.04; 75.3% in high LVEDP group vs. 67.5% in normal LVEDP group, P = 0.25). Pre‐treatment MR grade and New York Heart Association (NYHA) class were similar in both normal filling pressure and HFpEF groups. pMVR in HFpEF patients achieved effective heart failure symptom relief comparable with patients with normal filling pressures: significant decrease of MR grade and NYHA class, as well as significant reduction of heart failure hospitalizations 12 months after compared with 12 months before MitraClip.ConclusionPercutaneous edge‐to‐edge mitral valve repair for moderate–severe MR is an effective treatment option for symptom relief in HFpEF patients.