bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technology foresight for sustainable road freight transportation: Insights from a global real‐time Delphi study
Authors: Meyer Tobias , von der Gracht Heiko A. , Hartmann Evi 
Published: September 2021

AbstractOrganizations increasingly adopt technologies and logistics measures to improve their social sustainability, reduce transportation‐related carbon emissions, or even design their supply chains carbon negative. However, the speed at which this adoption is progressing is not fast enough to address the sustainability challenges of the world today. To gain deeper knowledge about the adoption process of sustainability‐related measures in road freight transportation, this paper examines barriers currently hindering a broader market penetration and derives expected timeframes when mass adoption of 14 relevant technologies will occur. Furthermore, the technologies' impacts on the economic, environmental, and social dimensions of sustainability are discussed providing recommendations, on which technologies the respective stakeholders might focus on in the future. Since we want to examines a long‐term technology perspective of the next 25 years, we rely on systematic foresight methodology. More specifically, we collect empirical data by use of a real‐time Delphi survey, which particularly suits complex and uncertain environments. Our global panel includes 116 experts from 25 different countries. The assessments are grouped into short‐term, midterm, midterm to long‐term, and long‐term developments. The categories shed light on potential drivers and barriers to the implementation of the surveyed technologies. The findings emphasize the need to systematically select suitable measures and promote those that are expected to deliver short‐term sustainability improvements to address current deficits in a timely manner. The article further outlines the crucial role of politics in developing necessary regulative frameworks to drive sustainability in road freight transportation.
The antimuscarinic agent biperiden selectively impairs recognition of abstract figures without affecting the processing of non‐words
Authors: Toth Monika , Sambeth Anke , Blokland Arjan 
Published: September 2021

AbstractObjectivesThe present study investigated the effects of biperiden, a muscarinic type 1 antagonist, on the recognition performance of pre‐experimentally unfamiliar abstract figures and non‐words in healthy young volunteers. The aim was to examine whether 4 mg biperiden could model the recognition memory impairment seen in healthy aging.MethodsA double‐blind, placebo‐controlled, two‐way crossover study was conducted. We used a three‐phase (deep memorization, shallow memorization, and recognition) old/new discrimination paradigm in which memory strength was manipulated. Strong memories were induced by deep encoding and repetition. Deep encoding was encouraged by redrawing the abstract figures and mentioning existing rhyme words for the non‐words (semantic processing). Weak memories were created by merely instructing the participants to study the stimuli (shallow memorization).ResultsBiperiden impaired recognition accuracy and prolonged reaction times of the drawn and the studied abstract figures. However, participants were biased towards “old” responses in the placebo condition. The recognition of the new abstract figures was unaffected by the drug. Biperiden did not affect the recognition of the non‐words.ConclusionsAlthough biperiden may model age‐related deficits in episodic memory, the current findings indicate that biperiden does not mimic age‐related deficits in recognition performance.
Efficacy of the depot gonadotropin‐releasing hormone agonist protocol on in vitro fertilization outcomes in young poor ovarian responders from POSEIDON group 3
Authors: Li Wenshu , Zhang Wei , Zhao Huishan , Chu Yongli , Liu Xuemei 
Published: September 2021

AbstractObjectiveTo investigate whether the depot gonadotropin‐releasing hormone (GnRH) agonist protocol could improve in vitro fertilization (IVF) outcomes for young poor responders from POSEIDON group 3.MethodsThis retrospective cohort study was carried out from June 2017 to June 2020. A total of 451 patients were assigned to three groups depending on the ovarian stimulation protocols. The outcome parameters of IVF were compared in each group.ResultsPatients who received the depot GnRH agonist had significantly higher cumulative clinical pregnancy rates (50.88%, 32.02%, and 31.88%, respectively; P = 0.009 and P = 0.007) and cumulative live birth rate (48.25%, 26.97%, and 28.99%, respectively; P = 0.004 and P = 0.009) compared with mild ovarian stimulation protocol and GnRH antagonist protocol. They also had higher live birth rate per fresh embryo transfer cycle (47.78%, 32.35%, and 36.62%, respectively), but these differences were not statistically significant. Moreover, duration of stimulation, total dose of gonadotropins and endometrial thickness were significantly higher among women who received the depot GnRH agonist (P < 0.001). However, they had lower embryo transfer cancellation rate, and abnormal endometrium rate (P < 0.001).ConclusionThe depot GnRH agonist protocol may improve cumulative clinical pregnancy rate and cumulative live birth rate for young women with poor ovarian response from POSEIDON group 3.
A pair of chiral Cu(II)‐Tb(III)‐Fe(III) heterotrimetallic enantiomers: Structural, luminescent, and magnetic studies
Authors: Wang Zi‐Xuan , Yuan Ya‐Nan , Wang Qing‐Lun , Wang Qi , Meng Xiang‐Jian , Yang Chun 
Published: September 2021

AbstractOne chiral heterotrimetallic compound, [Cu(H2O){(R,R)‐valcy}Tb(CH3OH)2(H2O)(μ‐CN)Fe(CN)5]·[Cu(H2O){(R,R)‐valcy}Tb(CH3OH)1.5(H2O)1.5(μ‐CN)Fe(CN)5]·7.85H2O·2CH3OH (1) (H2(R,R)‐valcy = N,N′‐bis(3‐methoxysalicylidene)‐1R,2R‐1,2‐diaminocyclohexane), has been prepared and structurally characterized by X‐ray single‐crystal diffraction. In 1, the asymmetric trinuclear {CuIITbIIIFeIII} units are assembled into 1‐D supramolecular single chain by hydrogen‐bonds and the supramolecular chains are further connected into 2D sheets. Magnetic studies show overall weak ferromagnetic interaction and magnetic anisotropy. The enantiomer of 1, denoted as complex 2, derived from N,N′‐bis(3‐methoxysalicylidene)‐1S,2S‐1,2‐diaminocyclohexane was also synthesized and characterized by PXRD, Infrared spectra, CD spectra, and fluorescence spectra. The results indicated that complexes 1 and 2 are isomorphous exhibiting similar fluorescence properties.
Clinico‐radiographic comparative evaluation of 1% metformin gel plus platelet‐rich fibrin over platelet‐rich fibrin alone in the treatment of Grade II furcation defects: A randomized controlled double‐blind clinical trial
Authors: Swami Renuka K. , Kolte Abhay P. , Kolte Rajashri A. 
Published: September 2021

AbstractBackgroundThe present study was aimed to evaluate and compare the effects of 1% MF plus PRF over PRF alone in treatment of Grade II furcation defects, clinically and radiographically by using cone‐beam computed tomography.MethodsThis split‐mouth clinical trial randomly allotted 21 patients with 42 bilateral Grade II furcation defects into two groups. Group I was treated with PRF alone while Group II with 1% MF gel and PRF. The primary outcome parameters were clinical attachment level (CAL) and horizontal probing depth (HPD) while the secondary outcome parameters were probing depth (PD) and defect volume (DV). The clinical parameters were evaluated at 3, 6, and 12 months and the radiographic parameters at 12 months.ResultsBoth the study groups yielded improvements in assessed parameters; however, significantly greater mean reduction of PD, HPD, and CAL gain was observed in Group II (3.90 ± 0.78 mm, 2.94 ± 0.80 mm, and 3.42 ± 0.93 mm) in comparison with Group I (3.23 ± 0.90 mm, 1.96 ± 0.80 mm, and 2.67 ± 0.88 mm) at 12 months, respectively. A significant reduction of DV was exhibited radiographically in Group II (12.61 ± 4.01 mm3) as compared with Group I (9.14 ± 4.31 mm3) at the end of 12 months.ConclusionsBetter clinical and radiographic findings in terms of reduction in PD, HPD, CAL gain, and significant reduction in DV in Group II patients indicated that the combination therapy of 1% MF + PRF promotes regenerative ability within the periodontal tissues in Grade II furcation defects to a greater extent.
Connective tissue growth factor promotes cell‐to‐cell communication in human periodontal ligament stem cells via MAPK and PI3K pathway
Authors: Wu Zuping , Chen Sirui , He Yuying , Zhang Demao , Zou Shujuan , Xie Jing , Zhou Chenchen 
Published: September 2021

AbstractBackgroundCell–cell communication is an essential process to respond to biological stimuli and sustain the micro environmental homeostasis of human periodontal ligament stem cells (hPDLSCs). Connective tissue growth factor (CTGF), a critical secreted matrix protein, exhibits significant tasks in regulating the cell‐cell and cell‐matrix interactions. This study aimed to explore the relationship between CTGF and cell communication and the underlying mechanism.MethodsqRT‐PCR was used to detect CCN family, connexin, and pannexin family expression in hPDLSCs. Stimulation with CTGF, cell migration assay was performed to examine the wound repair. The scrape loading/dye transfer assay was employed to access lucifer Yellow molecules transfer efficiency mediated by cell‐cell communication. Connexin43 (Cx43), Pannexin1 (Panx1), MAPK, and the PI3K/Akt signaling pathway proteins were examined via Western blotting. Immunofluorescence was applied to visualize the localization of specific proteins within cells. Corresponding pathway inhibitors were applied to hPDLSCs to detect Cx43, Panx1 expression, and intercellular communication induced by CTGF.ResultsOur result showed that CTGF was the second most expressed CCN family member in hPDLSCs. Cx43, and Panx1 were the most widely expressed gap junction hemichannels in hPDLSCs. CTGF enhanced hPDLSCs migration in a dose‐dependent manner. CTGF promoted cell‐cell communication by up‐regulating Cx43 and Panx1. CTGF induced Akt, JNK, and p38 phosphorylation and subcellular relocation. Inhibiting corresponding pathways reduced Cx43 expression, thereby weakening CTGF‐induced cell‐cell communication. However, the Panx1 expression in CTGF‐treated hPDLSCs mainly depended on PI3K/Akt signaling.ConclusionWe provided novel evidence that CTGF promoted cell‐cell communication in hPDLSCs through MAPK and PI3K pathway.
Improved High‐Temperature Energy Storage Performance of PEI Dielectric Films by Introducing an SiO2 Insulating Layer
Authors: Zhang Tiandong , Yang Lianyin , Ruan Jinyu , Zhang Changhai , Chi Qingguo 
Published: September 2021

AbstractPolymer dielectrics have the advantages of flexibility, good insulation, high power density, etc., which are widely used in the fields of pulsed power and power electronics. However, the conduction loss increases sharply at elevated temperature, which leads to the severely degraded energy storage performances and limits the polymer dielectric films to be used at elevated temperature. To address this issue, the SiO2 layer is grown on both side of polyetherimide (PEI) films by magnetron sputtering technology, the SiO2/PEI/SiO2 composite films with a sandwiched structure are successfully constructed. The results show that by growing a wide band gap SiO2 layer between the PEI film and the metal electrode can improve the height of the potential barrier at the electrode/dielectric interface, thus effectively reducing the conduction loss. The maximum discharge energy density is 2.96 J cm−3 when the charge–discharge efficiency is above 90%, which outperforms the reported dielectric polymers and composites. In addition, combining with the cycling charging/discharging results, SiO2/PEI/SiO2 composite films are demonstrated to have significant long‐term reliability and excellent discharging capability at elevated temperature.
A Fast Self‐Healing Magnetic Nanocomposite for Magnetic Actuators
Authors: Tao Han‐Qing , Yue De‐Wei , Li Cheng‐Hui 
Published: September 2021

AbstractMagnetic actuators, which use magnetic effects for actuation, are very useful in many areas, such as electrical equipment, soft robots, and medical instruments. However, they inevitably suffer damage during long‐term use, leading to mechanical failure. Introduction of the self‐healing concept can solve this problem to a certain extent and extend their service life. Herein, a room‐temperature self‐healing magnetic nanocomposite is obtained using a simple, efficient, and environmental‐friendly strategy. In the authors' design, soft poly(dimethylsiloxane) (PDMS) polymeric materials are chosen as the matrix, and Fe3O4 nanoparticles are utilized as a functional magnetic nanofiller to obtain a new magnetic nanocomposite. By balancing the self‐healing property and mechanical performance, the optimal content of magnetic filler is determined to be 15 wt%. The optimized sample exhibits an ultimate tensile strength (0.44 MPa), a high tensile strain (400%), and an excellent self‐healing efficiency (62.2% mechanical recovery of fracture strength) at 25 °C for 30 min. Furthermore, this composite material shows an excellent and healable magnetic actuation performance. This new nanocomposite provides great potential for the magnetic actuation application.
RAS induced senescence of skin keratinocytes is mediated through Rho‐associated protein kinase (ROCK)
Authors: Lee Alex J. , Fraser Elise , Flowers Brittany , Kim Jee , Wong Kenneth , Cataisson Christophe , Liu Huaitian , Yang Howard , Lee Maxwell P. , Yuspa Stuart H. , Li Luowei 
Published: September 2021

AbstractCellular senescence is a well‐documented response to oncogene activation in many tissues. Multiple pathways are invoked to achieve senescence indicating its importance to counteract the transforming activities of oncogenic stimulation. We now report that the Rho‐associated protein kinase (ROCK) signaling pathway is a critical regulator of oncogene‐induced senescence in skin carcinogenesis. Transformation of mouse keratinocytes with oncogenic RAS upregulates ROCK activity and initiates a senescence response characterized by cell enlargement, growth inhibition, upregulation of senescence associated β‐galactosidase (SAβgal) expression, and release of multiple pro‐inflammatory factors comprising the senescence‐associated secretory phenotype (SASP). The addition of the ROCK inhibitor Y‐27632 and others prevents these senescence responses and maintains proliferating confluent RAS transformed keratinocyte cultures indefinitely. Mechanistically, oncogenic RAS transformation is associated with upregulation of cell cycle inhibitors p15Ink4b, p16Ink4a, and p19Arf and downregulation of p‐AKT, all of which are reversed by Y‐27632. RNA‐seq analysis of Y‐27632 treated RAS‐transformed keratinocytes indicated that the inhibitor reduced growth‐inhibitory gene expression profiles and maintained expression of proliferative pathways. Y‐27632 also reduced the expression of NF‐κB effector genes and the expression of IκBζ downstream mediators. The senescence inhibition from Y‐27632 was reversible, and upon its removal, senescence reoccurred in vitro with rapid upregulation of cell cycle inhibitors, SASP expression, and cell detachment. Y‐27632 treated cultured RAS‐keratinocytes formed tumors in the absence of the inhibitor when placed in skin orthografts suggesting that factors in the tumor microenvironment can overcome the drive to senescence imparted by overactive ROCK activity.
Anti‐disturbance inverse optimal control for systems with disturbances
Authors: Fan Zhong‐Xin , Chandra Adhikary Avizit , Li Shihua , Liu Rongjie 
Published: September 2021

AbstractInverse optimal control is a widely used technique for solving various optimal problems arising in the controlled system. However, this method becomes inapplicable to optimal problems when the system has disturbances. In this article, we propose a novel anti‐disturbance inverse optimal controller design for a class of high‐dimensional chain structure systems with any disturbances, matched, or mismatched. First, a disturbance observer is employed to get the estimates of the disturbances in the system. Then using backstepping approach, the disturbance estimation is incorporated in the virtual control laws, and consequently a control Lyapunov function (CLF) is obtained. Finally, a composite controller is designed by developing an inverse optimal control method using the obtained CLF function. We show the stability analysis of the anti‐disturbance controller with rigorous proofs, which minimizes an optimal index while the output converges. Moreover, simulation study and analysis for real application to DC–DC buck converters reveal that the proposed composite controller achieves good performance and stabilizes the system with disturbances.
Advances in polymer‐based matte coatings: A review
Authors: Yong Qiwen , Xu Dan , Liu Qi , Xiao Yao , Wei Daidong 
Published: September 2021

AbstractIn modern society, polymer‐based matte coatings have gained widespread attention for its low gloss and exquisite texture characteristics, which are capable of providing soft‐light environmental atmosphere and pleasant tactile feeling. This paper reports the definition of gloss, the measuring method, and classification of gloss, the mechanism, and method of extinction, as well as the factors that affect the gloss of films. The most significant work of this paper focuses on the research advancements in synthesis methods and matting mechanisms of ultraviolet light‐curing matte coatings, powder matte coatings and water‐based matte coatings. In general, compared with traditional polymer‐based matte coatings, a new‐developed chemical matte coating can avoid film defects caused by the addition of matting agents. Meanwhile, it can lower the raw material costs and streamline the production procedures, which are supposed to be the future development trend of matting resin industry.
SPOP andCHD1alterations in prostate cancer: Relationship with PTEN loss, tumor grade, perineural infiltration, and PSA recurrence
Authors: Hernández‐Llodrà Silvia , Segalés Laura , Juanpere Nuria , Marta Lorenzo Tech , Salido Marta , Nonell Lara , David López Tech , Rodríguez‐Vida Alejo , Bellmunt Joaquim , Fumadó Lluís , Cecchini Lluís , Lloreta‐Trull Josep 
Published: September 2021

AbstractBackgroundIn the non‐ETSfusion of prostate cancer (PCa) pathway,SPOPmutations emerge as a distinct oncogenic driver subclass. BothSPOPdownregulation and mutation can lead toSPOPtarget stabilization promoting dysregulation of key regulatory pathways.CHD1gene is commonly deleted in PCa.CHD1loss significantly co‐occurs withSPOPmutations, resulting in a PCa subclass with increased AR transcriptional activity and with a specific epigenetic pattern.MethodsIn this study, SPOP alterations at mutational and protein levels andCHD1copy number alterations have been analyzed and correlated with ERG and PTEN protein expression and with the clinical pathological features of the patients.ResultsSPOP protein loss has been detected in 42.9% of the cases, and it has been strongly associated with PTEN protein loss (p < .001).CHD1gene loss has been detected in 24.5% andSPOPmutations in 5.9% of the cases. Loss ofCHD1has been strongly associated withSPOPmutations (p = .003) and has shown a trend to be associated with ERGwtcancers (p = .08).The loss of SPOP protein (p = .01) and the combination of PTEN and SPOP protein loss (p = .002) were both statistically more common in grade group 5 cancers, with a prevalence of 60% and 37.5%, respectively. Furthermore, SPOP loss/PTEN loss and SPOPwt/PTEN loss phenotypes were strongly associated with extraprostatic perineural infiltration (p = .007). StrongCHD1loss was associated with a shorter time to PSA recurrence in the univariate (p = .04), and showed a trend to be associated with the PSA recurrence risk in the multivariate analysis (p = .058).ConclusionsThe results of the present study suggest that the loss of SPOP protein expression, either alone or in combination with loss of PTEN and, on the other hand, a marked loss of theCHD1gene are very promising prognostic biomarkers in PCa.
Paediatric haemoptysis from multiple pulmonary artery aneurysms
Authors: Tovichien Prakarn , Kaeotawee Phatthareeda 
Published: September 2021

AbstractThe case of multiple peripheral pulmonary artery aneurysms in children presenting with haemoptysis following an episode of bacterial endocarditis is presented. They are extremely rare and clinically non‐specific but critical because early diagnosis is crucial for preventing sudden death from their rupture. Computed tomography pulmonary angiography remains the investigation of choice. Despite no consensus recommendation on the management, a multidisciplinary team should plan the beneficial approach with minimal procedure‐related morbidity and mortality to improve survival. This case report aimed to emphasize the recognition of this rare cause of haemoptysis in children.
Synthesis of L‐Malic Acid Based Poly(ester‐thioether)s via Thiol‐Ene Click Polymerization and Their Biodegradability
Authors: Sato Yuka , Takasu Akinori 
Published: September 2021

AbstractMany bio‐based polymers made from natural resources do not show satisfactory biodegradability, leading to micro‐plastic pollution. Here, thiol‐ene click polymerization of di‐3‐butenyl l‐malate (BMA) and diallyl l‐malate (AMA) with several dithiols including 1,8‐octanedithiol (OD) proceeded at 80 °C to give poly(ester‐thioether)s in excellent yields (70 %–90 %). Using an azo‐type radical trigger, polymerization proceeded more rapidly to give the expected poly(ester‐thioether)s with Mn ranging from 1.9×103 to 9.4×103 and a molecular dispersity index (Mw/Mn) of 2.19–3.66. Click polymerization using 1,2‐ethanedithiol (ED), ethylene bis(thioglycolate), and 2,3‐butanedithiol proceeded to give similar poly(ester‐thioether)s. In differential scanning calorimetry, all samples except for poly(BMA‐alt‐OD) had single Tg values between −37 and −47 °C. In biodegradation tests using activated sludge, poly(BMA‐alt‐OD) and poly(AMA‐alt‐ED) hardly showed biodegradability, but the other poly(ester‐thioether)s showed 13 %–22 % biodegradation after 28 days. Our results open up new avenues in the design of bio‐based polymers to reduce micro‐plastic pollution.
Towards cloud‐based unobtrusive monitoring in remote multi‐vendor environments
Authors: Moeyersons Jerico , Kerkhove Sarah , Wauters Tim , De Turck Filip , Volckaert Bruno 
Published: September 2021

AbstractNowadays, many complex multi‐vendor production environments, such as telecom infrastructures in smart cities or on‐board passenger information systems in trains, are based on micro‐services and deployed in the cloud. From a service integrator viewpoint, building new solutions for these environments, which can host a large number of externally designed and developed micro‐services, is often complex and error‐prone. This is in part due to undocumented behaviour or undocumented architectural specifications of such systems. Advanced service monitoring can offer a solution to quickly detect anomalies or unexpected service interaction behaviour during on‐site integration. However, the monitoring service should not have an impact on the production environment itself. Therefore, this article proposes an agent‐based unobtrusive monitoring platform, capable of monitoring both internally developed and externally developed services through the use of sidecar containers. It monitors state, metrics and network traffic at micro‐service level and the research was conducted as part of the DynAMo research project, a collaboration with various industry partners. Prototype evaluation proves that our solution has a negligible impact (below 0.02% CPU usage on average) on an existing micro‐service environment just as other monitoring systems like Prometheus while offering additional functionality focused on multi‐vendor service integration. This makes it suitable to be deployed in complex production domains to further aid on‐site integration and quickly find potential new anomalies.