bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating meaningful impact of Patient and Public Involvement: A Q methodology study among researchers and young people with a chronic condition
Authors: van Schelven Femke , Boeije Hennie , Rademakers Jany 
Published: December 2021

AbstractIntroductionAlthough Patient and Public Involvement (PPI) of young people with a chronic condition (YPCC) is receiving increasing attention, evidence of impact is lacking. This is partly due to inadequate understanding of what meaningful impact entails. This study aimed to gain an in‐depth understanding of researchers’ and YPCC's perspectives on meaningful impact.MethodsWe conducted a Q methodology study in a group of 26 researchers and a group of 20 YPCC with experience in PPI. Participants ranked statements about impact (e.g., ‘YPCC acquire new knowledge and skills’) based on their agreement with them. During interviews, they reflected on their rankings (Q sorts). Factor analysis was conducted to identify similar patterns in the individual Q sorts. The interviews were used to determine and interpret the final factor solution. The resulting factors represented distinct perspectives on meaningful impact.ResultsFour distinct perspectives on meaningful impact of PPI were identified. Two were predominantly based on the Q sorts of researchers, for example improving research quality and facilitating dialogue and understanding, and two on the Q sorts of YPCC, for example achieving equality and inclusivity and doing justice to YPCC's rights. The factors were defined by 37 Q sorts (80%); 9 Q sorts did not load significantly on any of the factors.ConclusionThe results indicate that researchers and YPCC can have different views about the meaningful impact of PPI. The perspectives identified here can serve as an aid when discussing these different views and formulating operational indicators of impact.Patient or Public ContributionAn adolescent with a chronic condition was involved in the early phases of this study. She helped in formulating the statements and recruiting YPCC.
Eosinophil plays a crucial role in intestinal mucositis induced by antineoplastic chemotherapy
Authors: Arifa Raquel D. N. , Brito Camila B. , de Paula Talles P. , Lima Renata L. , Menezes‐Garcia Zélia , Cassini‐Vieira Puebla , Vilas Boas Fabrício A. , Queiroz‐Junior Celso M. , da Silva Janine M. , da Silva Tarcília A. , Barcelos Lucíola S. , Fagundes Caio T. , Teixeira Mauro M. , Souza Daniele G. 
Published: December 2021

AbstractMucositis is a major clinical complication associated with cancer treatment and may limit the benefit of chemotherapy. Leukocytes and inflammatory mediators have been extensively associated with mucositis severity. However, the role of eosinophils in the pathophysiology of chemotherapy‐induced mucositis remains to be elucidated. Here, using GATA‐1‐deficient mice, we investigated the role of eosinophils in intestinal mucositis. There was marked accumulation of eosinophils in mice given irinotecan and eosinophil ablation inhibited intestinal mucositis. Treatment with Evasin‐4, a chemokine receptor antagonist, reduced the recruitment of eosinophils and decreased irinotecan‐induced mucositis. Importantly, Evasin‐4 did not interfere negatively with the antitumour effects of irinotecan. Evasin‐4 was of benefit for mice given high doses of irinotecan once Evasin‐4‐treated mice presented delayed mortality. Altogether, our findings suggest that Evasin‐4 may have significant mucosal‐protective effects in the context of antineoplastic chemotherapy and may, therefore, be useful in combination with anticancer treatment in cancer patients.
Injection techniques for midface volumization using soft tissue hyaluronic acid fillers designed for dynamic facial movement
Authors: Galadari Hassan , Weinkle Susan H. 
Published: December 2021

AbstractVolume loss of the face occurs over time; thus, volume enhancement of the midface can counteract the effects of aging. Hyaluronic acid (HA) fillers are often used for facial revolumization for a more youthful appearance due to their favorable outcomes and safety profiles. A patient‐centric approach, in which dynamic facial expressions are considered, is needed for optimal aesthetic results. In addition, injectors must be familiar with midface anatomy, how it is affected by the aging process, and must also consider the rheological and physical properties of fillers, including their stretch and dynamic strength.In this article, optimal injection techniques are described for a new range of HA‐based fillers for midface revolumization using a needle, cannula, or both. The layering technique involves product placement in both the deep and superficial fat compartments to achieve natural‐looking outcomes at rest and during motion.The Resilient Hyaluronic Acid (RHA®) line of fillers was designed to maintain their durability and integrity while adapting to the dynamic movements of the face. RHA 2 is applicable for superficial placement, whereas the balanced stretch and dynamic strength of RHA 3 render it more versatile. The novel rheological properties of RHA 4, with the highest dynamic strength and sufficient stretch, allow it to be injected superficially and into deep facial compartments.Depending on patient characteristics, the appropriate RHA filler can be chosen to reach the goal of a natural, younger appearance and avoid overfilling.
Platelet‐Rich Plasma Treatment for Accelerated Androgenetic Alopecia Pattern Hair Loss After COVID‐19 Infection: A Case Series
Authors: İşlek Akif , Karaaslan Engin , Şimşek Sadullah , Merve Çetin Funda 
Published: December 2021

AbstractBackgroundHair‐related manifestations such as alopecia areata or telogen effluvium were reported during COVID‐19 disease. Accelerated hair loss with androgenetic alopecia (AGA) pattern or management has not been discussed before.AimsThis study aimed to examine the accelerated AGA pattern hair loss and management with PRP treatment.Materials and MethodsThis study was designed prospectively and nine patients included to study confirmed PCR test for COVID‐19 infection. Patients underwent platelet‐rich plasma (PRP) injections for 4 sessions. Results were accessed with the hair pull test (HPT) and self‐administered hair growth questionnaire (HGQ).ResultsNine patients were admitted with complaints of hair loss after an average of 220 ± 24.2 (min: 182 max: 264) day after recovery of COVID‐19. Mean age of the patients was 33.8 ±8.4 years old (min: 26, max: 52). Six (66.7%) patients were male, and three (33.3%) of them were female. HPT score decreased to 6.0 ± 1.6 after the first PRP application (p = 0.007, CI 95%:2.7–5.2) and decreased to 1.2 ± 0.8 after the last PRP session (p = 0.008, CI 95%: 6.4–11.1). Five (55.5%) of the patients described the treatment as “very effective” after treatment with HGQ.ConclusionsAccelerated hair loss associated with COVID‐19 continues in long term and PRP treatment provides a satisfactory solution.
Validity of the Morse Fall Scale and the Johns Hopkins Fall Risk Assessment Tool for fall risk assessment in an acute care setting
Authors: Kim Young Ju , Choi Kyoung‐Ok , Cho Suk Hyun , Kim Seok Jung 
Published: December 2021

AbstractAims and ObjectivesTo evaluate the measured fall risk score that more accurately reflects the changeable conditions in acute care settings, and to efficiently evaluate the association between falls and fall risk score.BackgroundThe Morse Fall Scale (MFS) is a well‐known easy‐to‐use tool, while the Johns Hopkins Fall Risk Assessment Tool (JHFRAT) consists of items with high specificity. Evaluating suitable fall‐risk assessment tools to measure these changeable conditions may contribute to preventing falls in acute care settings.DesignRetrospective case–control study using the STROBE checklist.MethodsIn an acute care setting (708‐bedded university hospital with a regional emergency medical centre), the non‐fall group was adjusted to fall group using propensity score matching. According to the fall rate of 3–5%, non‐fall groups for each tool were selected (1386 and 1947) from the before adjusted data, and the fall groups included 42 and 59. The applied covariates were individual characteristics that ordinarily changed such as age, gender, diagnostic department and hospitalisation period. The adjusted data were analysed using generalised estimating equations and mixed effect model.ResultsAfter adjustment, the fall group measured using the JHFRAT had a significantly higher difference between the initial and re‐measured total score than the non‐fall group. The JHFRAT, especially with the re‐measured score, had a higher AUC value for predicting falls than the MFS. MFS's sensitivity was 85.7%, and specificity was 58.8% at 50 points; for JHFRAT, these were 67.8% and 80.2% at 14 points, respectively. These cut‐off points were used to evaluate validity during tool development and are commonly used as reference scores.ConclusionsJHFRAT more accurately reflects acute changeable conditions related to fall risk measurements after admission.Relevance to clinical practiceJHFRAT may be useful for effective fall prevention activities in acute care settings.
Vagus nerve ultrasound in transthyretin familial amyloid polyneuropathy: A pilot study
Authors: Du Kang , Xu Ke , Chu Xujun , Tang Yuwei , Lv He , Zhang Wei , Wang Zhaoxia , Yuan Yun , Meng Lingchao 
Published: December 2021

AbstractBackground and PurposeAutonomic dysfunction is common in transthyretin familial amyloid polyneuropathy (TTR‐FAP). Because ultrasonography is a powerful tool to study peripheral neuropathy, vagus nerve (VN) ultrasonography was used in our study to investigate the possible changes of the dimension of VN in TTR‐FAP.MethodsEighteen patients with TTR‐FAP and 17 age‐ and gender‐matched individuals without any neuropathies were enrolled in a pilot study. The cross‐sectional areas (CSAs) were measured bilaterally on transverse scans of vagus, median, and ulnar nerves. Clinical data were collected to explore the correlations with CSAs of VN.ResultsThe median CSAs of VN in TTR‐FAP were 3.5 (2.0‐6.0) mm2 on the right side and 2.5 (1.0‐6.0) mm2 on the left side, compared with 2.0 (1.0‐3.0) mm2 and 1.0 (1.0‐2.0) mm2 for healthy controls (HCs). There was a significant difference between the two groups on both sides (p < .001). The mean VN CSAs were correlated positively with the course of disease (r = .7203, p = .0016)（not including the patient with the longest disease course), the Composite Autonomic Symptom Score 31 (r = .5252, p = .0252), the left ventricular posterior wall thickness (r = .5426, p = .0200), and the interventricular septum thickness (r = .5103, p = .0305). The cutoff values of right and left VN CSAs to identify TTR‐FAP from HCs were 2.5 and 1.5 mm2 and the areas under the curve were .9395 and .8856, with a high sensitivity (.889 and .889) and specificity (.941 and .765), respectively.ConclusionVN enlargement is prevalent among TTR‐FAP patients. VN ultrasonography may be an important clinical tool for assessing the severity of autonomic dysfunction in TTR‐FAP.
Family‐supportive supervisor behaviors (FSSB) and work‐family conflict: The role of stereotype content, supervisor gender, and gender role beliefs
Authors: Yu Andrew , Pichler Shaun , Russo Marcello , Hammer Leslie 
Published: December 2021

Existing research consistently shows that informal workplace support, such as family‐supportive supervisor behaviors (FSSB), are more effective at reducing work–family conflict than formal organizational supports. The purpose of this study is to integrate propositions from the stereotype content model and social role theory to understand how family‐supportive supervision is related to social evaluations of supervisors (i.e., perceptions of supervisor warmth and competence) and identify boundary conditions (i.e., supervisor gender and employee gender role beliefs) to help researchers and practitioners understand how these relationships affect work–family conflict. We test our hypotheses using two studies, one an experimental vignette study and the other a two‐wave survey study of working individuals with family or caregiving responsibilities. Our results suggest that FSSB are importantly related to how employees socially evaluate their supervisors along the dimensions of warmth and competence; supervisor gender moderates the relationship between FSSB and perceived competence (but not warmth); employee gender role beliefs moderates both these relationship (but in a counterintuitive way for supervisor competence); and we find evidence that warmth and competence mediate the effects that FSSB have on work–family conflict. Implications for theory, future research, and practice are discussed.Practitioner points

Supervisors and organizations should consider how employee perceptions of supervisor competence and warmth impact employee perceptions of family supportiveness.

When enacting family supportive behavior, it is important for supervisors to demonstrate warmth, such as through nonverbal communication and body language.

Family‐supportive supervisor behavior (FSSB) interventions should consider manipulating not only dimensions of FSSB, but also behaviors tied to perceptions of competence and warmth.
The effect of labor‐market differentials on interregional migration in Spain: A meta‐regression analysis
Authors: Alvarez Maximiliano , Royuela Vicente 
Published: December 2021

AbstractThis paper performs a meta‐regression analysis to derive the role of techniques, data and variable's definition on the effect of the labor‐market determinants on interregional migration. We use Spain as a case of study, a country with heterogeneous and even counterintuitive behavior of internal migration flows to its labor‐market drivers. We use data from studies released over the last 40 years. The results show that migration flows respond to labor‐market differentials in a theoretically consistent way. We find that the vast diversity in the studies’ attributes is behind the significant heterogeneity of their estimated effects. Differences in aggregation level, variables measures, model specification, and the national economic context influence the identification of the push and pull effects.
Amino acid pattern of rumen microorganisms in cattle fed mixed diets—An update
Authors: Gresner Nina , Rodehutscord Markus , Südekum Karl‐Heinz 
Published: December 2021

AbstractRumen microorganisms turn small N‐containing compounds into amino acids (AA) and contribute considerably to the supply of AA absorbed from the small intestine. Previous studies summarized the literature on microbial AA patterns, most recently in 2017 (Sok et al. Journal of Dairy Science, 100, 5241–5249). The present study intended to identify the microbial AA pattern typical when feeding Central European diets and a maximum proportion of concentrate (PCO; dry matter (DM) basis) of 0.60. Data sets were created from the literature for liquid (LAB)‐ and particle (PAB)‐associated bacteria, total bacteria and protozoa, including 16, 9, 27 and 8 studies and 36, 21, 60 and 18 diets respectively. Because the only differences detected between LAB and PAB were slightly higher Phe and lower Thr percentages in PAB (p < 0.05), results for bacteria were pooled. A further data set evaluated AA‐N (AAN) as a proportion of total N in microbial fractions and a final data set estimated protozoal contributions to total microbial N (TMN) flow to the duodenum, which were used to calculate weighted TMN AA patterns. Protozoa showed higher Lys, Asp, Glu, Ile and Phe and lower Ala, Arg, Gly, Met, Ser, Thr and Val proportions than bacteria (p < 0.05). The AAN percentage of total N in bacteria and protozoa showed large, unexplained variations, averaging 79.0% and 70.6% (p > 0.05) respectively. Estimation of protozoal contribution to TMN resulted in a cattle‐specific mixed model including PCO and DM intake (DMI) per unit of metabolic body size (kg0.75) as fixed effects (RMSE = 3.77). With moderate PCO and DMI between 80 and 180 g/kg0.75, which corresponds to a DMI of approximately 10 to 25 kg in a cow with 650 kg body weight, protozoal contribution ranged between 9% and 26% of TMN. Within this range, the estimated protozoal contribution to TMN resulted in minor effects on the total microbial AA pattern.
Avian skulls represent a diverse ornithuromorph fauna from the Lower Cretaceous Xiagou Formation, Gansu Province, China
Authors: O'Connor Jingmai K. , Stidham Thomas A. , Harris Jerald D. , Lamanna Matthew C. , Bailleul Alida M. , Hu Han , Wang Min , You Hai‐Lu 
Published: December 2021

AbstractWe describe six specimens consisting of cranial remains and associated partial presacral axial series belonging to ornithuromorph birds from the Changma locality of the Lower Cretacous Xiagou Formation of northwestern Gansu Province, China. Comparison among specimens is limited by the paucity of overlapping elements, their differing exposed views, and, in some specimens, poor preservation. Despite this, three separate taxa are represented, evidenced by differences in their dentary dentitions: one specimen is edentulous, another has sharp, closely spaced, relatively high‐crowned and peg‐like teeth, and a third preserves blunt, relatively low‐crowned teeth placed in a communal groove, a morphology previously reported among adult birds only in Hesperornithiformes. We propose that the high‐crowned specimen may be referred to Gansus yumenensis based on shared similarities with the closely related Iteravis huchzermeyeri, including a very similar dentition and an edentulous premaxilla with elongate, unfused frontal processes and no palatal processes. The two other specimens are considered new taxa, for which we erect the names Meemannavis ductrix gen. et sp. nov. and Brevidentavis zhangi gen. et sp. nov. These new specimens confirm that the Changma locality is dominated by ornithuromorph birds and contribute to a better understanding of this important avifauna. The observed variation in dental morphology hints at trophic diversity like that observed in ornithuromorphs from the penecontemporaneous Jehol Group of northeastern China.
Let's talk about the negative experiences of Black mental health service users in England: Now is the moment to consider watchful waiting to support their recovery
Authors: Tuffour Isaac 
Published: December 2021

AbstractWatchful waiting is a concept that is traditionally not associated with severe and enduring mental illness. This paper, however, boldly argues that the concept could be used as a ground‐breaking and accessible antidote to the perceived inequality experienced by black service users experiencing both mild and severe mental illnesses in England. The novel concepts proposed in this paper are not intended to be consensual, but rather uncompromising to provoke critical thinking in mental health practice. A conceptual framework for watchful waiting in mental health is suggested.
Identity in Martin‐Löf type theory
Authors: Klev Ansten 
Published: December 2021

AbstractThe logic of identity contains riches not seen through the coarse lens of predicate logic. This is one of several lessons to draw from the subtle treatment of identity in Martin‐Löf type theory, to which the reader will be introduced in this article. After a brief general introduction we shall mainly be concerned with the distinction between identity propositions and identity judgements. These differ from each other both in logical form and in logical strength. Along the way, connections to philosophical debates concerning identity are noted. Some use of logical symbolism is inevitable in any serious discussion of type theory, but the emphasis here is on basic ideas rather than technicalities.
Outcome-Guided Sparse K-Means for Disease Subtype Discovery via Integrating Phenotypic Data with High-Dimensional Transcriptomic Data
Authors: Meng Lingsong , Avram Dorina , Tseng George , Huo Zhiguang 
Published: December 2021

AbstractThe discovery of disease subtypes is an essential step for developing precision medicine, and disease subtyping via omics data has become a popular approach. While promising, subtypes obtained from existing approaches are not necessarily associated with clinical outcomes. With the rich clinical data along with the omics data in modern epidemiology cohorts, it is urgent to develop an outcome-guided clustering algorithm to fully integrate the phenotypic data with the high-dimensional omics data. Hence, we extended a sparse K-means method to an outcome-guided sparse K-means (GuidedSparseKmeans) method. An unified objective function was proposed, which was comprised of (i) weighted K-means to perform sample clusterings; (ii) lasso regularizations to perform gene selection from the high-dimensional omics data; and (iii) incorporation of a phenotypic variable from the clinical dataset to facilitate biologically meaningful clustering results. By iteratively optimizing the objective function, we will simultaneously obtain a phenotype-related sample clustering results and gene selection results. We demonstrated the superior performance of the GuidedSparseKmeans by comparing with existing clustering methods in simulations and applications of high-dimensional transcriptomic data of breast cancer and Alzheimer's disease. Our algorithm has been implemented into an R package, which is publicly available on GitHub ( https://github.com/LingsongMeng/GuidedSparseKmeans).
Affective judgment in spatial context: Orienting within physical spaces containing people and things
Authors: Blaison Christophe 
Published: December 2021

AbstractThis article reviews our experimental work about affective judgment in spatial context. This type of judgment serves to regulate one's distance toward people and things in physical space. The main idea is that orienting within physical space requires not only knowing where places are but also how places feel. This, in turn, depends on the influence of people and things contained in space on one's affective appraisal of the surroundings. Based on fundamental principles of social cognition, affective judgment in spatial context combines people's beliefs about how influence unfolds into the surroundings with comparison, categorization and information integration processes. Out comes a subjective affective representation of physical space that is cognitively coherent within a given spatial frame of reference. I review our work according to main topics and discuss four possible directions for future research.