bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of targeted therapy for kidney damage with tuberous sclerosis in a child (clinical case)
Authors: Morozov S. L. , Piruzieva O. R. , Dlin V. V. 
Published: July 2021

Tuberous sclerosis is a polysystemic, genetically determined, autosomal dominant orphan disease that affects approximately 1 in 10,000 people worldwide. Kidney damage in tuberous sclerosis is the leading cause of death due to serious complications, the most common of which is angiomyolipoma bleeding. A feature of renal angiomyolipomas is that they begin to progress and increase in volume from an early age, leading to the progression of chronic kidney disease, while angiomyolipomas more than 30 mm in diameter are at risk of bleeding. Currently, pharmacotherapy of tuberous sclerosis with mTOR inhibitors is the most effective worldwide. In this article, a clinical case of targeted therapy of tuberous sclerosis is presented, the effectiveness is demonstrated, and the features of the course of tuberous sclerosis are also given on a specific example.
ALTERAÇÕES COMPORTAMENTAIS NO ETILISMO CRÔNICO: UMA VISÃO DO NEUROFUNCIONAMENTO E MOLECULAR
Authors: Moreira da Silveira Francis 
Published: July 2021

O estudo em tela tem como objetivo geral realizar um levantamento bibliográfico sobre a questão do etilismo crônico e suas onsequências. Tratou-se de uma revisão da literatura, com a abordagem qualitativa, com materiais disponibilizados nos portais cadêmicos Scientific Electronic Library Online (SCIELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), a oleta dos dados ocorreu no decorrer do primeiro bimestre de 2021. Os resultados alcançados apontam que o etanol é uma das rogas mais utilizadas. Embora os fatores ambientais e genéticos contribuam para a etiologia dos transtornos por uso de álcool, são s ações do etanol no cérebro que explicam as mudanças comportamentais agudas relacionadas ao etanol, como estimulante eguido de efeitos depressivos e mudanças crônicas no comportamento incluindo uso escalonado, tolerância, busca compulsiva e dependência. Conclui-se que para compreender os efeitos do etilismo crônico, é importante considerar a influência de uma ampla ama de variáveis em um determinado comportamento ou conjunto de comportamentos. Os fundamentos dos defeitos cerebrais nduzidos pelo álcool são multivariados; até o momento, a literatura disponível não apoia a afirmação de que qualquer variável pode er consistente e completamente responsável por essas deficiências.
Politiques de la littérature
Authors: Dujin Anne , Gefen Alexandre 
Published: July 2021

Autant qu’une expérience esthétique, nous cherchons aujourd’hui dans la littérature des ressources pour comprendre le monde contemporain, voire le transformer. En témoigne l’importance prise par les enjeux d’écologie, de féminisme ou de dénonciation des inégalités dans la littérature de ce début du xxi e siècle, qui prend des formes renouvelées : le témoignage ou l’enquête, qui réinventent la littérature comme forme politique.
Littérature et démocratie
Authors: Gefen Alexandre 
Published: July 2021

L’œuvre littéraire est réinvestie d’une portée politique : interpellation située et pragmatique de la démocratie, fonction critique de l’écriture littéraire face aux discours médiatiques et demande de relation, comme en témoignent certains récits intimes récents qui favorisent le sens de l’égalité.
La fabrique de l’universel
Authors: Sarr Felwine , Gefen Alexandre , Régnier Quentin 
Published: July 2021

Dans ses romans comme dans ses essais, Felwine Sarr place les notions de relation et d’altérité au cœur de sa réflexion. Il évoque dans cet entretien le rôle propre de la littérature – fiction ou poésie – dans la production de ces liens, et l’émergence d’espaces politiques communs.
Contre le retour du droit de prélèvement en droit français : une vue de la pratique du droit international
Authors: Le Grand de Belleroche Diane 
Published: July 2021

« Réintroduire le mécanisme du droit de prélèvement, dans une rédaction ouverte à tous les héritiers quelle que soit leur nationalité, conduirait ainsi à poser une nouvelle dérogation aux règles de conflit posées par le règlement, en contradiction avec l’esprit de celui-ci. En outre, il est délicat de considérer que la dérogation qui pourrait être ouverte par le droit français par le rétablissement du droit de prélèvement entrerait nécessairement dans le champ de l’exception d’ordre public visé à l’article 35 du règlement […] En effet, […] l’objectif du règlement visant à garantir une plus grande visibilité en matière successorale […], pourrait conduire la Cour de justice de l’Union européenne à considérer qu’un État membre ne peut pas permettre l’éviction systématique des lois étrangères ne prévoyant pas de réserve. La réintroduction du droit de prélèvement ferait donc courir un risque sérieux de censure du dispositif par la Cour de justice de l’Union européenne dans le cadre d’un recours en manquement ou par la voie d’une question préjudicielle. » 1
Lafarge : de l’internationalisation à la firme mondiale, une résistible ascension ? (1947-2014)
Authors: Barjot Dominique 
Published: July 2021

Jusqu’à sa fusion en 2014, avec Holcim, son principal concurrent européen, Lafarge a offert un bon exemple d’entreprise française devenue mondiale. Numéro deux français des matériaux de construction derrière Saint-Gobain, Lafarge s’est imposée avec un succès comparable. Elle le doit à une internationalisation précoce. Fondée en 1833, la maison Lafarge est demeurée longtemps familiale, avant de se transformer, à partir de 1947, en firme managériale. Depuis cette date, deux périodes se sont succédées. De 1947 à 1992, l’entreprise s’est progressivement multinationalisée. Les années 1947 à 1973 ont été marquées par une croissance forte financée par autofinancement, élargissement limité de l’actionnariat et endettement à long et moyen terme. Trois facteurs ont alors cumulé leurs effets positifs : un management rationnel (passage au staff and line , en privilégiant une logique multidivisionnelle), une stratégie réussie de redéploiement international de l’Afrique francophone vers l’Amérique du Nord et un effort de recherche-développement très supérieur à celui de la concurrence. Ces choix ont permis, dans un environnement économique plus difficile, de consolider les positions internationales du groupe par la conquête du marché américain, où le groupe s’est imposé, de 1974 à 1992, comme le numéro 1, tout en se renforçant en Europe. Dans les années 1993 à 2007, le groupe Lafarge s’est imposé comme une firme de dimension mondiale en privilégiant le renforcement de ses positions nord-américaines et la conquête des pays émergents. Toutefois, pour financer une croissance rapide, tant organique qu’externe, il a fallu satisfaire un actionnariat de plus en plus éclaté et flottant. Ce n’est qu’à partir de 2008 que l’actionnariat s’est stabilisé, mais au prix d’une perte d’indépendance stratégique. Celle-ci a conduit à la fusion. Certes, elle a donné naissance à un leader mondial, mais au sein duquel la technostructure managériale a perdu le pouvoir au profit de la famille Schmidheiny et de ses alliés belges et égyptiens, d’où la nationalité suisse de l’actuel LafargeHolcim.
La stratégie de Renault en Russie des années 1960 à nos jours
Authors: Vinogradov Boris 
Published: July 2021

L’industrie automobile française demeure aujourd’hui l’une des plus importantes du monde : en 2018, son industrie automobile nationale plaçait la France à la dixième place des producteurs mondiaux et au troisième rang en Europe. Les positions de Renault apparaissent particulièrement fortes en Russie. Le constructeur automobile français maintient sa présence sur le marché russe, malgré les nombreux bouleversements que connaît le pays au XX e siècle. À l’époque soviétique, la marque au losange réussit de nombreux projets industriels sur le territoire de l’URSS et réalise un transfert d’importance des technologies. Après la chute de l’Union soviétique, Renault investit dans la construction d’une usine automobile à Moscou. L’usine « Renault Russie » devient en 2014, la quatrième usine du Groupe Renault en volume de production. Il s’agira ici d’observer et d’expliquer la stratégie de la marque sur le marché russe.
Virgin France, coup d’essai de l’internationalisation d’un groupe entre opportunisme et décentralisation
Authors: Champroux Nathalie Anna 
Published: July 2021

La France fut le pays tremplin de l’internationalisation du groupe britannique Virgin. Au début des années 1980, Virgin parvint à y implanter avec succès Virgin France SA, la première filiale étrangère de son label britannique d’édition phonographique, Virgin Records. En 1988, la France s’enrichit d’une autre activité de la maison mère britannique : la vente de produits culturels. Virgin Stores SA, société bien française malgré son nom anglophone, inaugura la série de filiales étrangères de la britannique Virgin Retail ; elle fut à l’origine du premier Virgin Megastore ouvert hors du Royaume-Uni, sur l’avenue des Champs-Élysées de Paris. Le cas de la création et de l’évolution de ces deux filiales françaises de Virgin présente l’intérêt d’alimenter les théories privilégiant l’opportunisme, l’influence des réseaux et la décentralisation comme moteurs de l’internationalisation des entreprises de service. Virgin France SA n’est pas née d’une stratégie d’internationalisation mûrement planifiée en réponse au besoin désespéré de fuir un marché intérieur saturé ou de satisfaire des partenaires financiers exigeants. Plutôt, la filiale fut le fruit du hasard d’une rencontre entre le français Patrick Zelnik et le britannique Richard Branson. L’enthousiasme du premier, alors directeur du marketing chez Polydor, a nourri chez le second, fondateur et patron de Virgin, l’idée d’une filiale française. Le lien social qui se tissa entre les deux hommes incita ensuite Branson à laisser carte-blanche à Zelnik. Bien ancré dans le marché de l’industrie créative en plein essor dans les années 1980, ce fut ce dernier qui eut l’idée de concurrencer la FNAC, chaîne de distribution de produits culturels déjà bien implantée dans l’Hexagone, avec un Virgin Megastore parisien. Ce sont ces deux incursions particulières de Virgin sur le marché français qu’il s’agit d’étudier ici, dans ce qu’elles révèlent du processus d’internationalisation du groupe.
Appraisal Survey of the Knowledge, Attitudes, and Behaviors of Jordanian Society toward Diet and Nutrition during Covid-19 Era
Authors: Alhaj Omar A. , Al-Sayyed Hiba F. , AlRasheed Maha M. , Jahrami Haitham 
Published: July 2021

Background This study aimed to evaluate the knowledge, attitudes, and behavior (KAB) of the Jordanian society toward nutrition and diet during the COVID-19 era. Design and methods This study is an observational, crosssectional study using a structured, validated, reproducible, selfadministered online Arabic questionnaire. KAB of the study participants was assessed via a web-based, structured, validated, reproducible Arabic questionnaire. The tool for the assessment of the KAB was composed of 33-closed-ended multi-answer questions. Results A total of 672 people were surveyed, 70.2% were between 18 and 34, and 69.5% were females. Participants have paid little attention to the healthfulness of their diet in the last year. The majority of participant's attitudes towards using different approaches to manage weight in the next year were: eating smaller portions for weight management, tracking to maximize the amount of time of physical activity, and substituting lowercalorie foods for full-calorie alternatives. Only tenth of participants utilize the time to perform physical activity. The majority made changes to their diet and exercise, and strictly follow commitment in connection with planning for the following year. Conclusions Educators, legislatives, food manufacturers, household heads, and policymakers are called upon to improve Jordanians’ KAB on nutrition and diet. Furthermore, Jordanian nutrition and diet behavior can be invested to improve the dietary interventions designed by nutrition and dietetics professionals.
Validation of surgical APGAR score in abdominal surgeries at a tertiary care teaching hospital in South India
Authors: Bhushanam K. Yadhu , Samantaray Aloka , Thottikat Kaarthika , Pasupuleti Hemalatha , Devi R. Sri , Rao Mangu Hanumantha , Chukkaluru Sumadhu 
Published: July 2021

Background:
A ten-point surgical APGAR score (SAS) has been previously developed and validated that provides surgeons with a simple, objective and direct rating of operative performance and risk. This score has been evaluated in different types of surgeries till date. We validated SAS in both elective and emergency abdominal surgeries separately which was not done previously.

Methods:
In this prospective, observational and longitudinal study, 105 surgical cases undergoing open abdominal surgeries were studied. The SAS was calculated for all patients, patients were followed up for the occurrence of any major complications or mortality during hospital stay after surgery. All the patients were divided into three groups based on their SAS score (high risk: SAS 0–4, moderate risk: SAS 5–7 and low risk: SAS 8–10) using a threshold that has been previously established.

Results:
The occurrence of major complications was significantly higher in high-risk SAS group (12%) than in the moderate risk group (5%). In the low-risk SAS group, the occurrence of major complications was low (1%). The mortality rate in high-risk SAS was more than that in low-risk SAS group with statistical significance both in elective and emergency cases.

Conclusions:
In our study, we found that patients who belong to high-risk SAS group were significantly associated with post-operative major complications and mortality in both elective and emergency surgeries. A patient with low intraoperative SAS should be considered at risk and monitored meticulously.

Trial Registration:
Clinical Trials Registry-India (CTRI) identifier No. CTRI/2019/02/017567.
Circulating serum micro-ribonucleic acids 155 and 205 before and after surgery in patients with breast cancer
Authors: Rama K. , Bitla Aparna R. , Hulikal Narendra , Yootla Mutheeswaraiah , Yadagiri Lakshmi Amancharla , Asha T. , Manickavasagam M. , Srinivasa Rao P. V. L. N. 
Published: July 2021

Background:
Micro-ribonucleic acids (miRNAs) are small non-coding RNAs that regulate gene expression. Expression of miRNAs has been shown to be dysregulated in patients with breast cancer. These markers have been shown to be potential markers of diagnostic significance. We intended to study the usefulness of miRNA-155 and miRNA-205 in monitoring response to surgery by monitoring their pre- and post-operative expression.

Methods:
Twenty patients newly diagnosed with malignant breast disease along with 20 age-matched females not having any breast lesion were included in the study. Reverse transcription–polymerase chain reaction was used to assess the expression of circulating miRNAs.

Results:
MiRNA-155 was found to be significantly upregulated and miRNA-205 was significantly downregulated in patients with breast cancer compared to controls. There was no change in expression of miRNA-155 and miRNA-205 following surgery.

Conclusions:
The findings of the present study do not support the role of miRNA-155 and miRNA-205 as markers suitable for follow-up. However, the findings of the present study need to be confirmed in a larger sample size and samples collected over a defined post-operative period.
Study of association of age at presentation with outcome in patients with head-and-neck cancer
Authors: Kesarwani Radha , Singh Astha , Singh Virendra , Prakash Gyan 
Published: July 2021

Background:
Elderly patients with head-and-neck cancer (HNC) are increasing in number. Outcome of HNC with relation to age is controversial.

Methods:
In this hospital-based retrospective study, medical records of 76 patients of HNC who were treated with surgery followed by radiotherapy or radiotherapy with or without chemotherapy were analysed. The patients were divided into two age groups: Group I patients ≥55 years and Group II patients <55 years. Patient characteristics, treatment and toxicities were evaluated. They were followed-up clinically and radiologically up to a median time of 16 months.

Results:
Complete response was 94.4% and 80.05% in Group I and II, respectively. Disease-free survival (DFS) was 53.67% and 47.8% in Group I and II, respectively (P = 0.332), whereas overall survival (OS) was 67.34% and 49.42% in two groups, respectively (P = 0.234); hence, DFS and OS are not statistically significant.

Conclusion:
Complete response was more frequently among patients older than 55 years in comparison to patients younger than 55 years, even though the dose delivered to them is lower. There was no statistically significant difference in both groups with respect to DFS and OS. Haematological toxicities were found more in older patients in comparison to patients younger than 55 years.
Clinical and laboratory profile of tuberculosis in HIV-positive patients and occurrence of tuberculosis-associated immune reconstitution inflammatory syndrome
Authors: Subbalaxmi M. V. S. , Guduru Sravanthi , Kapoor Anu , Chandra Naval 
Published: July 2021

Background:
Tuberculosis (TB) is the most common opportunistic disease in human immunodeficiency virus (HIV)-positive persons.

Methods:
We prospectively studied the clinical, radiological, cytological, histopathological and microbiological presentation of TB in HIV-positive patients and occurrence of immune reconstitution inflammatory syndrome (IRIS) in HIV TB co-infected patients.

Results:
Out of 70 patients studied, 47 were male. Fever was the most common symptom (n = 61, 87.1%). The most common laboratory finding was anaemia (n = 67, 95.7%). In 32 (45.7%) patients presenting with TB, HIV infection was diagnosed. A CD4+ count <200/mm3 was seen in 57 (81.4%) patients. Extra-pulmonary TB (44.3%) was more common than pulmonary TB. All patients were started on anti-TB treatment; 6 had developed IRIS.

Conclusions:
Our observations suggest that screening all HIV-seropositive patients for TB and careful monitoring for the occurrence of IRIS while on anti-TB treatment are helpful in managing HIV HIV-TB co-infected patients.
Membranous nephropathy and malignancy
Authors: Khelgi Vinod , Stack Paul , Venuthurupalli Sree Krishna 
Published: July 2021

Background:
There is variable association of membranous nephropathy (MN) with malignancy predominantly of solid organ tumours. There is debate as to how to screen and or investigate for evidence of malignancy in this group.

Methods:
Retrospective analysis of kidney biopsies performed between 2006 and 2016. Patients with MN were identified and clinical course including age, degree of proteinuria, histology details, treatment and rates of remission documented. Evidence of malignancy and its temporal association with MN noted.

Results:
Over ten-year period 216 biopsies were performed of which 20 patients (10.8%) had MN [mean age 48.5 years (range 20-82 years); there were to males]. Of these, eight patients (40%) had evidence of malignancy. Four patients were diagnosed with malignancy prior to the biopsy (mean duration 39.7 months) whereas, 4 patients were diagnosed after the biopsy (mean duration 6.7 months). Patients with MN and malignancy were older compared to those without malignancy (63.0 Vs 38.2 years) (P = 0.0054). There was no statistical difference in degree of proteinuria, focal segmental glomerulosclerosis lesions, and number of inflammatory cells in the study population.

Conclusions:
Higher prevalence (40%) of malignancy was associated with biopsy proven MN from Darling Downs which was statistically significant. Although age appropriate investigations are indicated in these patients, it may be prudent to actively look for evidence of underlying malignancy especially in elderly population given the concerns associated with immunosuppressive therapies.
Peculiarities of communication of managing civil servants and the control area institutions in case of emergency at NPP
Authors: Prylypko V. A. , Petrychenko O. O. , Morozova M. M. , Bondarenko I. V. 
Published: July 2021

Background. Implementing the measures to protect the control area (CA) population is ensured by Emergency Planning and Response System of “NNEGC” Energoatom” in case of accidents and emergencies at NPPs of Ukraine (EPR) as a part of the Unified State Civil Protection System (USCPS).
Purpose. Specifying the features of interaction between different management structures in the domain of radiation protection of the control area population in case of emergencies at nuclear power plants.
Materials and methods. The expert evaluation method was utilized in the research process. Five main groups of experts, responsible for the state of radiation protection of various population groups of South-Ukrainian NPP (SUNPP) control area and qualified according to the key criteria, have been formed. Semi-closed-ended and open-ended questions were used in the expert evaluations, a 5-point scale was used in closed-ended ones, and nominal ones were used for others. When processing, statistical methods designed to analyze non-numerical information were applied.
Results and discussion. In case of emergency at SUNPP, the system of alerting municipal authority executives of cities and rural settlements of the control area is “more or less” effective and can be achieved within 30 minutes. The control area population is provided with stable iodine agents, the population of Yuzhnoukrainsk is provided with individual protective gear in the best way; Voznesensk and rural settlements have a little lower levels of supply. The rural areas are characterized by the lowest level of first aid kits, protective clothing and respirators supplies. Implementing the measures to limit the consumption of food contaminated with radionuclides and to provide “clean” one, as well as to restrict the consumption of drinking water contaminated with radionuclides, and to provide “clean” one is about 3.0 points (“approximately 50% of what is needed”).
Conclusion. The analysis of expert evaluation data shows that the NPP and the State Emergency Service conduct regular training in case of emergency at NPP forming stereotypes of behavior of managing civil servants. The level of readiness to put protective measures in action in case of emergency at SUNPP varies, depending on the state service and institution as well the location of those ones in the control area. The level of readiness in the edge city is the highest; it is lower in cities and the lowest in the rural areas. The level of being equipped with key facilities is extremely low in civil protection services and primary healthcare units.