bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of Lijianmin-Chengkun Complexes and Their Oncological Application in Osseous and Intraarticular Lesions Around the Knee
Authors: Shao Xianhao , Li Jianmin , Zhang Ailin , Yao Yuan , Sun Feifei , Li Zhenzhong , Liu Tao , Hou Haiqing , Li Qiuyao , Li Zhenfeng , Gao Xiaofei , Yang Qiang , Li Yuchun , Li Ka , Cheng Kun 
Published: December 2021

Objective: This research aims to refresh the limited understanding about the canal and vascular structures within the epiphysis and metaphysis of the tibia and femur and their oncological significance.Methods: This study was started with characterization of a novel structure using radiographs and anatomic dissections, followed by a descriptive clinical study with 55 participants to investigate the effects of tumors on this novel discovery and a retrospective cohort study with 82 participants to investigate whether the structure would be a risk factor for tumor recurrence after the curettage of giant cell tumor of bone.Results: A new anatomical knee structure, the Lijianmin-Chengkun (LC) complex, was discovered in healthy adults, and its clinical implications were examined in this study. This new-found anatomical structure is composed of an epiphyseal and metaphyseal canal which surrounds a blood vessel, foramen, and foramen-covered synovium. All LC complexes showed similar radiographical, anatomical, and histological characteristics and were located within specific tibial and femoral intercondylar regions. These LC complexes seem to facilitate tumor residue and extension and may be a risk factor for tumor recurrence after curettage of femoral and tibial giant cell tumors (P = 0.031).Conclusion: The LC complexes are related to local tumor recurrence and bidirectional tumor dissemination between intraosseous and intraarticular regions. These findings have opened up a new perspective and may provide new targets for intervention in malignant and aggressive tumors around the knee joint.
A Nomogram Based on Clinicopathological and Ultrasound Imaging Characteristics for Predicting Cervical Lymph Node Metastasis in cN0 Unilateral Papillary Thyroid Microcarcinoma
Authors: Zhang Lina , Ling Yuwei , Zhao Ye , Li Kaifu , Zhao Jing , Kang Hua 
Published: December 2021

Objective: The aim of this study was to establish a practical nomogram for preoperatively predicting the possibility of cervical lymph node metastasis (CLNM) based on clinicopathological and ultrasound (US) imaging characteristics in patients with clinically node-negative (cN0) unilateral papillary thyroid microcarcinoma (PTMC) in order to determine a personal surgical volume and therapeutic strategy.Methods: A total of 269 consecutive patients diagnosed with cN0 unilateral PTMC by postoperative pathological examination from January 2018 to December 2020 were retrospectively analyzed. All the patients underwent lobectomy or thyroidectomy with routine prophylactic central lymph node dissection (CLND) and were divided into a CLNM group and a non-CLNM group. Using logistic regression, the least absolute shrinkage and selection operator (LASSO) regression analysis was applied to determine the risk factors for CLNM in patients with unilateral cN0 PTMC. A nomogram including risk-factor screening using LASSO regression for predicting the CLNM in patients with cN0 unilateral PTMC was further developed and validated.Results: Risk factors identified by LASSO regression, including age, sex, tumor size, presence of extrathyroidal extension (ETE), tumor diameter/lobe thickness (D/T), tumor location, and coexistent benign lesions, were potential predictors for CLNM in patients with cN0 unilateral PTMC. Meanwhile, age (odds ratio [OR] = 0.261, 95% CI.104–0.605; P = 0.003), sex (men: OR = 3.866; 95% CI 1.758–8.880; P &lt; 0.001), ETE (OR = 3.821; 95% CI 1.168–13.861; P = 0.032), D/T (OR = 72.411; 95% CI 5.483–1212.497; P &lt; 0.001), and coexistent benign lesions (OR = 3.112 95% CI 1.407–7.303; P = 0.007) were shown to be significantly related to CLNM by multivariant logistic regression. A nomogram for predicting CLNM in patients with cN0 unilateral PTMC was established based on the risk factors identified by the LASSO regression analysis. The receiver operating characteristic (ROC) curve for predicting CLNM by nomogram showed that the area under the curve (AUC) was 0.777 and exhibited an excellent consistency.Conclusions: A nomogram based on clinical and US imaging characteristics for predicting the probability of CLNM in patients with cN0 unilateral PTMC was developed, which showed a favorable predictive value and consistency. Further prospective research to observe the oncological outcomes is necessary to determine whether the nomogram could potentially guide a personalized surgical volume and surgical approach.
Implication of ARID1A Undercurrents and PDL1, TP53 Overexpression in Advanced Gastric Cancer
Authors: Qadir Jasiya , Majid Sabhiya , Khan Mosin Saleem , Rashid Fouzia , Wani Mumtaz Din , Bhat Showkat Ahmad 
Published: December 2021

AT-rich interactive domain-containing protein 1A (ARID1A), TP53 and programmed cell death-ligand 1 (PDL1) are involved in several protein interactions that regulate the expression of various cancer-related genes involved in the progression of the cell cycle, cell proliferation, DNA repair, and apoptosis. In addition, gene expression analysis identified some common downstream targets of ARID1A and TP53. It has been established that tumors formed by ARID1A-deficient cancer cells exhibited elevated PDL1 expression. However, the aberrations in these molecules have not been studied in this population especially in Gastric Cancer (GC). In this backdrop we aimed to investigate the role of the ARID1A mutation and expression of ARID1A, TP53 and PDL1 genes in the etiopathogenesis of Gastric Cancer (GC) in the ethnic Kashmiri population (North India). The study included 103 histologically confirmed GC cases. The mutations, if any, in exon-9 of ARID1A gene was analysed by Polymerase Chain Reaction (PCR) followed by Sanger sequencing. The mRNA expression of the ARID1A, TP53 and PDL1 genes was analysed by Quantitative real time-PCR (qRT-PCR). We identified a nonsense mutation (c.3219; C &gt; T) in exon-9 among two GC patients (∼2.0%), which introduces a premature stop codon at protein position 1073. The mRNA expression of the ARID1A, TP53 and PDL1 gene was significantly reduced in 25.3% and elevated in 47.6 and 39.8% of GC cases respectively with a mean fold change of 0.63, 2.93 and 2.43. The data revealed that reduced mRNA expression of ARID1A and elevated mRNA expression of TP53 and PDL1 was significantly associated with the high-grade and advanced stage of cancer. Our study proposes that ARAD1A under-expression and overexpression of TP53 and PDL1 might be crucial for tumor progression with TP53 and PDL1 acting synergistically.
EFEKTIVITAS PERIZINAN BERUSAHA MELALUI SISTEM ELEKTRONIK TERINTEGRASI ONLINE SINGLE SUBMISSION (OSS) PADA DINAS PENANAMAN MODAL DAN PELAYANAN TERPADU SATU PINTU KABUPATEN ROKAN HULU
Authors: Manik Rian Andrianus , Mayarni Mayarni 
Published: December 2021

AbstractOnline Single Submission is an information technology-based licensing system innovation that integrates regional and central licensing in accordance with the mandate of Government Regulation Number 24 of 2018 concerning Electronically Integrated Business Licensing Services. The purpose of this study was to determine whether the OSS program was running. The use of this OSS program is to shorten the licensing bureaucracy. This research is descriptive with a case study approach and the data needed are primary and secondary data derived from observations, interviews, and documentation which are analyzed by researchers so as to obtain accurate and clear data. The results of this study indicate that the OSS program at the Office of Investment and One Stop Services in Rokan Hulu Regency has been running effectively. The accuracy of the program targets was in accordance with the expectations set before the program was launched. The socialization of the program has not yet been effectively carried out. The achievement of program objectives is in accordance with the initial purpose of this program, the community has felt the convenience offered by OSS. Program monitoring is still not fully effective but has started to lead to improvements.Keywords: Effectiveness; Online Single Submission; Program AbstrakOnline Single Submission merupakan inovasi sistem perizinan berbasis teknologi informasi yang mengintegrasikan perizinan di daerah dan pusat sesuai amanat Peraturan Pemerintah Nomor 24 Tahun 2018 tentang Pelayanan Perizinan Berusaha Terintegrasi Secara Elektronik. Tujuan penelitian ini adalah untuk mengetahui apakah program OSS berjalan efektif atau tidak. Penggunaan program OSS ini untuk mempersingkat birokrasi perizinan. Penelitian ini bersifat deskriptif dengan pendekatan studi kasus serta data yang diperlukan ialah data primer dan sekunder yang berasal dari observasi, wawancara, dokumentasi yang dianalisis oleh peneliti sehingga mendapatkan data yang akurat dan jelas. Hasil penelitian ini menunjukan bahwa program OSS di Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kabupaten Rokan Hulu sudah berjalan efektif. Ketepan sasaran program sudah sesuai dengan harapan yang ditetapkan sebelum program ini diluncurkan. Untuk sosialisasi program masih belum efektif dilakukan. Pencapaian tujuan program sudah sesuai dengan tujuan awal program ini dibuat, masyarakat sudah merasakan kemudahan yang ditawarkan OSS. Untuk pemantauan program masih belum sepenuhnya efektif tetapi sudah mulai mengarah kepada perbaikan. Kata Kunci: Efektivitas; Online Single Submission; Program
Práticas de atenção ao parto realizadas em uma maternidade de um município paraibano
Authors: Marinho de Almeida Franco Claudia Maria , Melo Bomfim Isabela , Mônica Borges Studart Rita , Elisângela Teixeira Lima Francisca , Resende Sousa Gleison , Silvino Serra Kalyni 
Published: December 2021

Objetivo: Descrever as práticas de atenção ao parto realizadas em uma maternidade de um município paraibano. Método: Trata-se de um estudo exploratório e descritivo, com abordagem quantitativa realizado no município de Cabedelo, Paraíba. A amostra foi não probabilística por conveniência constituída por 12 puérperas, em março e abril de 2018. Para a coleta dos dados foi utilizado um formulário específico e a análise estatística ocorreu utilizando-se o programa Microsoft Excel. Posteriormente, os dados foram apresentados em tabelas e interpretados a partir da literatura. O presente estudo foi aprovado sob nº CAAE 83170617.8.0000.5176. Resultados: Constatou-se que as práticas prejudiciais ao parto como manobra de Kristeller, episiotomia, utilização de ocitocina de rotina, posição de litotomia e clampeamento precoce do cordão umbilical ainda costumam ser realizadas com frequência. Conclusão: Percebe-se que é de extrema relevância promover cursos de atualização e capacitação baseados em evidências científicas para os profissionais de saúde.
OPTIMALISASI TAMAN BACA GAMPONG BUKU PAGA DALAM UPAYA MENGGALAKKAN GERAKAN LITERASI MASYARAKAT DI DESA PAYA GABOH
Authors: Nuraina Nuraina , Marhami Marhami , Alvina Sirry , Imanda Riska , Faradhillah Faradhillah 
Published: December 2021

Sebelum Covid-19 Warga Desa Paya Gaboh memiliki kegiatan harian seperti pengajian bagi anak-anak, pemuda-pemudi dan ibu/bapak, kegiatan olahraga seperti sepakbola, bolavolly dan lain-lain. Pada masa pandemi seperti sekarang ini kegiatan-kegiatan tersebut sedikit dibatasi, sehingga disela-sela aktivitas, masih terdapat beberapa warga yang kurang memanfaatkan waktu, hal ini terlihat banyaknya anak-anak yang hanya duduk-duduk di balai dan di warung-warung dengan bermain HP. Selain itu di Desa Paya Gaboh belum memiliki sebuah pustaka atau ruang yang berisi kumpulan buku-buku yang dapat dimanfaatkan masyarakat untuk membaca sebagai upaya membentuk wawasan yang luas dan memanfaatkan waktu luang dengan hal yang bermanfaat, untuk itu diperlukan taman/ruang baca gampong dalam upaya menggalakkan gerakan literasi msyarakat di desa tersebut. Adapun metode yang digunakan dalam pengabdian ini terdiri dari 5 tahap, yaitu: Tahapan pertama, melakukan pendekatan masyarakat; Tahap kedua, malakukan pengambilan data awal; Tahap tiga, melakukan identifikasi masalah; Tahap keempat, melakukan analisa dari setiap masalah; Tahap terakhir, menentukan solusi. Solusinya adalah membentuk sebuah taman baca gampong. Luaran yang dihasilkan dalam pengabdian ini yaitu Taman Baca Gampong Buku Paga. Adapun hasil evaluasi diperoleh presentase rata-rata diatas 85% peritemnya, menunjukkan bahwa program taman baca dapat digunakan dengan baik. Kemudian tentang minat baca diperoleh presentase diatas 86% peritemnya, itu menunjukkan bahwa minat baca masyarakat bagus. Dan yang terakhir mengenai parstisipasi masyarakat mendapat presentase rata-rata diatas 92% peritemnya, hal ini menunjukkan bahwa masyarakat senang dan antusias sehingga banyak yang ikut berpartisipasi dalam taman baca tersebut. Dengan demikian taman baca yang telah dibuat dalam kegiatan pengabdian ini sangat bermanfaat bagi masyarakat gampong Payah Gaboh
Moroccan Social Media Platforms and COVID-19 Misinformation
Authors: Aboulghazi Hanane 
Published: December 2021

COVID-19 pandemic has been accompanied by a massive ‘infodemic’ and an over-abundance of disinformation that makes it hard for people to find trustworthy sources and reliable guidance when they need it. Young Moroccan internet users resort to social media for their news, and easily fall prey to the misinformation and fake news they encounter online. When it concerns public health, disinformation can turn into a lethal weapon. This is further exacerbated at the time of COVID-19 pandemic. To tackle this, the present research paper answers the research questions using a qualitative method, particularly semi-structured interviews preferable in exploratory research where the purpose is to gain an understanding of spreading online misinformation in the age of COVID-19. Semi-structured Interviews are conducted via “Google Meet” and “Zoom” using video-conferencing among 12 young Moroccan social media activists and professionals. The main research findings have shown that young Moroccan social media users have been consuming fake news about the Coronavirus, which has been especially prevalent on the most popular platforms, Facebook, Whats App and YouTube. Other results have shown that the mainstream media failed to debunk misinformation by subjecting them to rigorous fact checking experiments, lack of Media Information Literacy research in the form of crisis audits and crisis planning, Moroccan social media are ill prepared for crisis manual and conducting crisis training. These ensure that media regulators are not better equipped to handle any misinformation in health crisis situations. Therefore, media literacy is not only about how to use the computer and do an internet search, it also involves helping young Moroccan people to deal with disinformation in crisis situations, and realize that anyone anywhere can put up a very official-looking websites. These websites masquerade as high-credibility sources that have been spreading misinformation about COVID-19. Therefore, the government needs.
Pengaruh Penggunaan Aplikasi “Si Pesek” (Stop Tindakan Pelecehan Seksual) Terhadap Pengetahuan Tentang Personal Safety Skill Pada Anak Usia Prasekolah di TK Manba’ul Huda Bekasi
Authors: Beri Edo Septa , Sutini Titin , Haryanto Rohadi 
Published: December 2021

Sexual child abuse is involving, persuading, or forcing a child to take part in sexual activities or encouraging the child to behave inappropriate sexual contact, and this is a frequent phenomenon. The purpose of this study was to identify the effect of using the application “si pesek” on personal safety skill knowledge in preschool children at Manba’ul Huda, Bekasi, West Java. The research design used was the equations experimental non equivalent control grop design with 30 respondents divided into two groups, intervention dan control. The result showed that the ads were the effect of giving the application “si pesek” on personal knowledge of safety skill with a p value 0.000 (0.05). There is an effect of confounding factors on children knowledge, namely age with p value 0.04 (0.05), environment with p value 0.04 (0.05), socio cultural with p value 0.04 (0.05) and information is the most significant with p value 0.02 (0.05). Based on the research results the application “si pesek” can be recommended as an educational tool in child nursing services to prevent sexual violence in preschoolersKeywords: Preschool children, sexual education, sexual abuse
PENERAPAN PARTICLE SWARM OPTIMIZATION PADA ALGORITMA C 4.5 UNTUK SELEKSI PENERIMAAN KARYAWAN
Authors: Wiyatno Agus 
Published: December 2021

The Employees are the most vital element of the company as they had a big contribution and involved almost for all section on how the company will go up and down. Employees and the company affect the efficiency, effectiveness,designing, producing goods and services, oversee the quality, market products, allocating financial resources, and determines the overall goals and strategies of the organization. Therefore, organizations need accurate information and sustainable in order to get suitable candidates with the qualifications of the organization. Model algorithms are widely used in research related to the employee is C4.5 decision tree classification model. Advantages of using adecision tree classification models are the result of the decision tree is simple and easy to understand. Many studies using the method of decision tree and classification tree in predicting the employees selection but results theaccuracy of the resulting value is less accurate. In this study created a C 4.5 Algorithm model and C 4.5 Algorithm model based on particle swarm optimization to get the rule in employees selection and provide a more accuratevalue of accuracy. After testing C 4.5 algorithm model based on particle swarm optimization, Implementation of particle swarm optimization can produce accuracy value of C 4.5 algorithm model from 80.80 % to 85.20 % and theAUC value from 0.878 to 0.891. By the formation the model selection of employees, the company can be helped for employee selection.
Efektivitas Vco (Virgin Coconut Oil) Untuk Menurunkan Gula Darah Puasa Pada Orang Dengan Obesitas
Authors: Muriyati  , Nadia Alfira  
Published: December 2021

latar belakang dari penelitian ini adalah Obesitas merupakan faktor resiko penyebab kematian ke-5 didunia. Sekitar 2,8 juta penduduk didunia meninggal akibat komplikasi obesitas, 23% menderita penyakit jantung iskemik, dan 7% sampai 41% memiliki resiko terkena kanker pada organ tertentu. Tujuan dari penelitian ini Untuk mengetahui efektivitas VCO (Virgin Coconut Oil) untuk menurunkan Gula Darah Puasa pada orang dengan Obesitas,.metode penelitian yang digunakan adalah quasi eksperiment dan hanya menggunakan satu kelompok dengan menggunakan total sampel sebanyak 30 orang. Hasilnya adalah Berdasarkan hasil penelitian di dapatkan perbedaan gula darah puasa pada kelompok kontrol dengan kelompok intervensi setelah diberikan VCO dengan nilai median selisih 29,5, secara klinis terdapat perbedaan bermakna namun secara statistik nilai p = 0,058. Yang berarti nilai p>0,05 secara statistik tidak ada perbedaan bermakna antara gula darah puasa kelompok intervensi dan kelompok kontrol setelah diberikan VCO, kesimpulan dan saran yaitu pada masyarakat agar berperilaku hidup yang sehat dengan menjaga pola makan yang baik dan mengatur aktivitas dengan baik khususnya bagi yang mengalami obesitas agar terhindar dari berbagai penyakit degeneratif akibat komplikasi dari obesitas dan menggunakan VCO sebagai upaya preventif.
Pengaruh Pemberian Pendamping Makanan Tambahan (PMT) Kepada Ibu Hamil Terhadap Kejadian Kekurangan Energi Kronik Di Wilayah Kerja Puskesmas Salasssae
Authors: Asmirati  , Mitra Asriani  , Andi Muhammad Haerul  , Asnidar  
Published: December 2021

Gizi pada masa kehamilan adalah salah satu faktor penting yang mempengaruhi perkembangan embrio dan janin serta status kesehatan ibu hamil. Kehamilan merupakan tahapan yang berkesinambungan, sehingga defesiensi pada suatu periode akan memberikan dampak secara berbeda pada outcome kehamilan. Periode perikonsepsional terdiri dari prekonsepsi, konsepsi, implantasi, plasentasi, serta masa embryogenesis. Kualitas bayi yang dilahirkan tergantung pada keadaan gizi ibu sebelum dan selama kehamilan. Tujuan penelitian ini untuk mengetahui pengaruh pemberian biskuit makanan tambahan (PMT) terhadap kenaikan status gizi pada ibu hamil trimester II yang mengalami kekurangan energi kronis. Penelitian ini dilaksanakan di puskesmas Tanete, dan Puskesmas Salassae Kabupaten Bulukumba sulawesi selatan. Rancangan dalam penelitian ini menggunakan Quasi Eksperimen. Variabel independen dalam penelitian ini adalah Pemberian Makanan Tambahan (PMT) kemudian variabel dependen ialah Lingkar Lengan Atas (LILA), variabel kontrolnya ialah Usia,Pendidikan dan paritas. Populasi dalam penelitian ini adalah 165 orang. Analisis Univariat digunakan untuk melihak karakteristik dari masing – masing responden. Analisis bivariat denagn menggunakan uji Wilcoxon sum rank test atau yang lebih dikenal dengan uji mann withney untuk menilai hasil analisis nilai LILA sebelum dan setelah pendampingan pemberian Biskuit PMT. Hasil penelitian: Rerata LILA pada kelompok yang diberikan pendampingan makanan tambahan (PMT) sebelum intervensi adalah 6,33±0,32 dan setelah intervensi meningkat menjadi 8,06±0,17 hasil uji statistik secara signifikan (p<0,05) yang berarti ada perbedaan LILA sebelum dan sesudah pemberian makanan tambahan (PMT). Rerata LILA pada kelompok yang tidak diberikan pendampingan makanan tambahan (PMT) sebelum intervensi adalah sebesar 6,39±0,28 dan setelah intervensi meningkat menjadi 8,73±0,20 hasil uji statistik secara signifikan (p<0,05) yang berarti ada perbedaan LILA sebelum dan setelah kelompok yang tidak diberikan pendampingan.
Perbandingan Tingkat Kecemasan Dalam Menghadapi Persalinan Pada Ibu Hamil Primigravida Dengan Multigravida Dimasa Pandemi Covid-19
Authors: Risnawati  , Andi Nurlaily  , Irmawati  , Mayasari Ira , Rusnawati  
Published: December 2021

Kehamilan merupakan peristiwa penting dan hal yang membahagiakan sekaligus menggelisahkan bagi seorang wanita. Kecemasan ini lazim terjadi pada ibu primigravida dikarenakan belum pernah melahirkan namun diera pandemic covid-19 dampak psikologis dan kekhawatiran terjadi pada ibu hamil yang akan pemicu terjadinya kecemasan.
Penelitian ini bertujuan untuk mengetahui perbandingan tingkat kecemasan dalam menghadapi persalinan pada ibu primigravida dengan multigravida trimester III kehamilan dan memberikan strategi dalam mengurangi kecemasan yakni Teknik pernafasan diafragma dimasa pandemic Covid-19. Metode yang digunakan dalam penelitian ini adalah analitik dengan jenis desain penelitian eksperimental quasi. Populasi dalam penelitian ini adalah ibu hamil trimester III di Puskesmas Bontobangun. Sampel dalam penelitian ini adalah ibu hamil trimester III(primigravida dan multigravida) berjumlah 25 orang. Hasil penelitian terdapat perbedaan rerata score derajat kecemasan bermakna pada kelompok intervensi dibandingkan kelompok control.