bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Treatment Together: a protocol for a multi-phase, community-based participatory, and co-design project to improve youth opioid treatment service experiences in British Columbia
Authors: Marchand Kirsten , Tallon Corinne , Katan Christina , Fairbank Jill , Fogarty Oonagh , Pellatt Katrina Marie , Turuba Roxanne , Mathias Steve , Barbic Skye 
Published: August 2021

Abstract
Background
Opioid use is one of the most critical public health issues as highly potent opioids contribute to rising rates of accidental opioid-related toxicity deaths. This crisis has affected people from all age groups, including youth (ages 15–24) who are in a critical developmental period where the stakes of opioid use are especially high. Efforts to reduce the significant harms of opioid use have focused on the expansion of evidence-based treatments, including medications for opioid use disorder (e.g. buprenorphine). While these treatments are unequivocally life saving, recent evidence suggests that they may not align with youths’ needs. Accordingly, the ‘Improving Treatment Together’ (ITT) project has been designed with the aim to improve youths’ opioid treatment service experiences and outcomes by co-developing, implementing, and measuring youth-centred opioid use treatment service innovations. This manuscript describes the protocol for this multi-phase project.

Methods
The ITT project follows community-based participatory research (CBPR) and strategically integrates co-design processes throughout its four phases. Upon establishing a project partnership between national, provincial and community-based organizations, Phase 1 follows four core elements of human-centred co-design (empathy, needs identification, ideation, prototyping) in nine separate workshops. These workshops will be held in four diverse communities with youth, caregivers and service providers who have accessed or delivered opioid treatment services. Phase 1 will culminate in the co-production of opioid treatment service innovations to be considered by the project’s partners for further co-development, pilot testing, and wider implementation during the remaining phases of the project. Throughout each phase, the project will collect and analyse both qualitative and quantitative research and evaluation data to determine the project’s impact.

Discussion
This protocol provides a detailed description of the ITT project, with an emphasis on the project’s application of co-design and CBPR processes, the planned research and implementation procedures, and the establishment of a unique partnership. To our knowledge, this is one of the first projects to integrate these participatory processes to the design, implementation and measurement of youth-centred opioid treatment services. Embedding these processes throughout each phase of the project will strengthen the relevance and feasibility of the project’s service delivery innovations.
Synthesis, characterization, and antioxidant activity in vitro of selenium-Euryale ferox Salisb. polysaccharide
Authors: Dong Fang , Zheng Hu-Zhe , Jeong Woo-Sik , Chung Shin-Kyo , Qu Zhong-Yuan , Zou Xiang , Liu Chen , Xiang Qiong , Feng Feng 
Published: August 2021

AbstractIn order to obtain and explore selenide composed of selenium and polysaccharide, three parameters were selected to optimize the synthesis process of selenium-Euryale ferox Salisb. polysaccharide (Se-ESPS) by Box-Behnken design. Furthermore, ESPS-B1 separated from ESPS was selenitized to Se-ESPS-B1 by the optimal synthesis process, then the characterization, and antioxidant activity in vitro of Se-ESPS-B1 were explored. The result manifested that the Se content of Se-ESPS was (2.915  ±  0.03) mg/g according to the optimal synthesis process of Se-ESPS (reaction time at 5 h, reaction temperature at 81 ℃, weight ratio of Na2SeO3 to ESPS at 0.9 g/g). A series of detection results indicated that the characterizations of Se-ESPS-B1 were apparently distinguished from that of ESPS-B1. Moreover, the antioxidant experiments in vitro demonstrated that Se-ESPS-B1 could exert antioxidant activity by scavenging DPPH, ABTS,·OH, and increasing reduction ability. In conclusion, the synthesis process is an effective approach to harvest selenium-polysaccharide, and Se-ESPS-B1 may be utilized as a potential antioxidant or selenium nutritional supplement.
Animal-borne acoustic data alone can provide high accuracy classification of activity budgets
Authors: Thiebault Andréa , Huetz Chloé , Pistorius Pierre , Aubin Thierry , Charrier Isabelle 
Published: August 2021

AbstractBackgroundStudies on animal behaviour often involve the quantification of the occurrence and duration of various activities. When direct observations are challenging (e.g., at night, in a burrow, at sea), animal-borne devices can be used to remotely record the movement and behaviour of an animal (e.g., changing body posture and movement, geographical position) and/or its immediate surrounding environment (e.g., wet or dry, pressure, temperature, light). Changes in these recorded variables are related to different activities undertaken by the animal. Here we explored the use of animal-borne acoustic recorders to automatically infer activities in seabirds.ResultsWe deployed acoustic recorders on Cape gannets and analysed sound data from 10 foraging trips. The different activities (flying, floating on water and diving) were associated with clearly distinguishable acoustic features. We developed a method to automatically identify the activities of equipped individuals, exclusively from animal-borne acoustic data. A random subset of four foraging trips was manually labelled and used to train a classification algorithm (k-nearest neighbour model). The algorithm correctly classified activities with a global accuracy of 98.46%. The model was then used to automatically assess the activity budgets on the remaining non-labelled data, as an illustrative example. In addition, we conducted a systematic review of studies that have previously used data from animal-borne devices to automatically classify animal behaviour (n = 61 classifications from 54 articles). The majority of studies (82%) used accelerometers (alone or in combination with other sensors, such as gyroscopes or magnetometers) for classifying activities, and to a lesser extent GPS, acoustic recorders or pressure sensors, all potentially providing a good accuracy of classification (> 90%).ConclusionThis article demonstrates that acoustic data alone can be used to reconstruct activity budgets with very good accuracy. In addition to the animal’s activity, acoustic devices record the environment of equipped animals (biophony, geophony, anthropophony) that can be essential to contextualise the behaviour of animals. They hence provide a valuable alternative to the set of tools available to assess animals’ behaviours and activities in the wild.
The relation of orthorexia with lifestyle habits: Arabic versions of the Eating Habits Questionnaire and the Dusseldorf Orthorexia Scale
Authors: Hallit Souheil , Barrada Juan Ramón , Salameh Pascale , Sacre Hala , Roncero María , Obeid Sahar 
Published: August 2021

Abstract
Background
Some of the commonly used tools to assess orthorexia nervosa (OrNe) do not allow a meaningful interpretation of the scores or yield mixed results about the dimensions needed to represent orthorexia. Since no advancement in the theoretical knowledge can be made without a thorough examination of the measurement aspects, this study aimed to evaluate the correlation between orthorexia nervosa (OrNe) and lifestyle habits, notably alcohol drinking, cigarette and waterpipe smoking, and physical exercise, and to validate and assess the psychometric properties of the Arabic versions of the Eating Habits Questionnaire (EHQ) and Düsseldorf Orthorexia Scale (DOS).

Methods
A total of 456 adult participants completed a self-administered questionnaire. Exploratory structural equation models were used to test the internal structure of the instruments. Shorter and more explicit versions were proposed for instruments. Pearson and partial correlations were computed between orthorexia scores and healthy behaviors scores.

Results
Regarding the internal structure of both EHQ and DOS, evidence favored the bi-dimensional construct of orthorexia. Both tools presented two theoretically clearly interpretable factors (OrNe and Healthy Orthorexia—HeOr—). The two questionnaires presented a high convergent validity, as dimensions with the same interpretation were correlated around 0.80. While OrNe was positively correlated with the use of unhealthy substances (higher alcohol use disorder, cigarette, and waterpipe dependence), HeOr was negatively associated with these behaviors.

Conclusion
Our results emphasize the idea that further attention should be paid to the multidimensional structure of orthorexia, as OrNe and HeOr present an opposite pattern of associations with healthy behaviors. An OrNe etiopathogenesis common to eating disorders can explain these differences.
A parallelization model for performance characterization of Spark Big Data jobs on Hadoop clusters
Authors: Ahmed N. , Barczak Andre L. C. , Rashid Mohammad A. , Susnjak Teo 
Published: August 2021

AbstractThis article proposes a new parallel performance model for different workloads of Spark Big Data applications running on Hadoop clusters. The proposed model can predict the runtime for generic workloads as a function of the number of executors, without necessarily knowing how the algorithms were implemented. For a certain problem size, it is shown that a model based on serial boundaries for a 2D arrangement of executors can fit the empirical data for various workloads. The empirical data was obtained from a real Hadoop cluster, using Spark and HiBench. The workloads used in this work were included WordCount, SVM, Kmeans, PageRank and Graph (Nweight). A particular runtime pattern emerged when adding more executors to run a job. For some workloads, the runtime was longer with more executors added. This phenomenon is predicted with the new model of parallelisation. The resulting equation from the model explains certain performance patterns that do not fit Amdahl’s law predictions, nor Gustafson’s equation. The results show that the proposed model achieved the best fit with all workloads and most of the data sizes, using the R-squared metric for the accuracy of the fitting of empirical data. The proposed model has advantages over machine learning models due to its simplicity, requiring a smaller number of experiments to fit the data. This is very useful to practitioners in the area of Big Data because they can predict runtime of specific applications by analysing the logs. In this work, the model is limited to changes in the number of executors for a fixed problem size.
Densification of agro-residues for sustainable energy generation: an overview
Authors: Ibitoye Segun E. , Jen Tien-Chien , Mahamood Rasheedat M. , Akinlabi Esther T. 
Published: August 2021

AbstractThe global demand for sustainable energy is increasing due to urbanization, industrialization, population, and developmental growth. Transforming the large quantities of biomass resources such as agro-residues/wastes could raise the energy supply and promote energy mix. Residues of biomass instituted in the rural and industrial centers are enormous, and poor management of these residues results in several indescribable environmental threats. The energy potential of these residues can provide job opportunities and income for nations. The generation and utilization of dissimilar biomass as feedstock for energy production via densification could advance the diversity of energy crops. An increase in renewable and clean energy demand will likely increase the request for biomass residues for renewable energy generation via densification. This will reduce the environmental challenges associated with burning and dumping of these residues in an open field. Densification is the process of compacting particles together through the application of pressure to form solid fuels. Marketable densification is usually carried out using conventional pressure-driven processes such as extrusion, screw press, piston type, hydraulic piston press, roller press, and pallet press (ring and flat die). Based on compaction, densification methods can be categorized into high-pressure, medium-pressure, and low-pressure compactions. The common densification processes are briquetting, pelletizing, bailing, and cubing. They manufacture solid fuel with desirable fuel characteristics—physical, mechanical, chemical, thermal, and combustion characteristics. Fuel briquettes and pellets have numerous advantages and applications both in domestic and industrial settings. However, for biomass to be rationally and efficiently utilized as solid fuel, it must be characterized to determine its fuel properties. Herein, an overview of the densification of biomass residues as a source of sustainable energy is presented.
Performance evaluation of water-repellent combat uniforms using a static manikin and human subjects under a rainfall tower system
Authors: Kwon Juyoun , Kim Kijoon , Ju Jeongkyun , Lee Joo-Young 
Published: August 2021

AbstractThe purpose of the present study was to evaluate the water-repellent properties of newly-developed combat uniforms using a rainfall tower system. Two types of water-repellent- combat uniforms with an identical level of water repellency through textile tests (WR_M and WR_T) were compared with an untreated-combat uniform (Control). A static manikin was used to evaluate water-repellent properties in a standing position and eight male subjects participated to test walking effects under artificial rainfall. The results showed that it took to saturate the upper body was longer for WR_T than WR_M and Control in the standing position for both normal and heavy rain conditions (P < 0.05). The lower body in WR_T was rarely wet in the standing position after 60 min, whereas the lower body was partially wet while walking within 30 min. Changes in clothing weight after the rainfall test were 729 ± 21, 256 ± 36 and 137 ± 25 g per trial for Control, WR_M, and WR_T, respectively (P < 0.001). Subjects expressed better tactile, less colder, less heavier, and less humid sensations and less uncomfortable feeling for WR_T than Control or WR_M (P < 0.05), while WR_M was better only for tactile sensation and heaviness than Control (P < 0.05). Ten-time-washes had not impaired the water-repellent properties of WR_M or WR_T. These results indicated that the rainfall tower test is valid to verify water-repellent property of clothing ensemble and suggest a possibility of classifying the water repellency of clothing ensemble into sub-levels of an excellent and a fair class. Further studies on wider range of experimental conditions to validate the current results are required.
Estimating potential range shift of some wild bees in response to climate change scenarios in northwestern regions of Iran
Authors: Rahimi Ehsan , Barghjelveh Shahindokht , Dong Pinliang 
Published: August 2021

AbstractBackgroundClimate change is occurring rapidly around the world, and is predicted to have a large impact on biodiversity. Various studies have shown that climate change can alter the geographical distribution of wild bees. As climate change affects the species distribution and causes range shift, the degree of range shift and the quality of the habitats are becoming more important for securing the species diversity. In addition, those pollinator insects are contributing not only to shaping the natural ecosystem but also to increased crop production. The distributional and habitat quality changes of wild bees are of utmost importance in the climate change era. This study aims to investigate the impact of climate change on distributional and habitat quality changes of five wild bees in northwestern regions of Iran under two representative concentration pathway scenarios (RCP 4.5 and RCP 8.5). We used species distribution models to predict the potential range shift of these species in the year 2070.ResultThe effects of climate change on different species are different, and the increase in temperature mainly expands the distribution ranges of wild bees, except for one species that is estimated to have a reduced potential range. Therefore, the increase in temperature would force wild bees to shift to higher latitudes. There was also significant uncertainty in the use of different models and the number of environmental layers employed in the modeling of habitat suitability.ConclusionThe increase in temperature caused the expansion of species distribution and wider areas would be available to the studied species in the future. However, not all of this possible range may include high-quality habitats, and wild bees may limit their niche to suitable habitats. On the other hand, the movement of species to higher latitudes will cause a mismatch between farms and suitable areas for wild bees, and as a result, farmers will face a shortage of pollination from wild bees. We suggest that farmers in these areas be aware of the effects of climate change on agricultural production and consider the use of managed bees in the future.
Metabolomics affirms traditional alcoholic beverage raksi as a remedy for high-altitude sickness
Authors: Majumder Soumya , Ghosh Arindam , Chakraborty Sourav , Saha Sumedha , Bhattacharya Malay 
Published: August 2021

AbstractRaksi, a fermented distilled alcoholic beverage, is an ethnic drink consumed in high altitude regions of Singalila Ridge of the Himalayas and in adjoining high altitude places in Nepal, northern and north eastern part of India and Tibetan plateau. Likejaanr,tongba,nigar,chhyang, and other fermented ethnic beverages,raksiis considered as an element of ethnopharmacology of high altitude with claims of medicinal properties. An ethnobiological survey was done in the study area prior to collection and identification ofraksisamples. In this research, tworaksisamples (khokim raksiandchimphing raksi) of Singalila Ridge of the Himalayas were investigated by metabolite profiling using gas chromatography-mass spectrometry analysis. Results of the experiment showed presence of several respiratory protective, cardioprotective, neuroprotective, anti-inflammatory, and antioxidant components which have properties to prevent various high altitude illnesses. Moreover, large quantities of bioactive terpenoids, fatty acid derivatives, coumarins, and peptides were detected whose chemotaxonomy and biosynthesis pathways were further studied. This metabolomics investigation not only affirmedRaksias a remedy for high-altitude sickness but also helped in understanding the importance of this type of ethnic foods in high altitude ethnoecology. This research onraksiin the fields of ethnobiology and metabolomics is a cumulative approach which has opened the door for in-depth investigations on similar ethnic foods. However, further experiments onraksiare surely needed in ethnobiology, microbiology, biochemistry, and food technology.
Fruit size control by a zinc finger protein regulating pericarp cell size in tomato
Authors: Zhao Fangfang , Zhang Jiajing , Weng Lin , Li Meng , Wang Quanhua , Xiao Han 
Published: August 2021

AbstractFruit size is largely defined by the number and size of cells in the fruit. Endoreduplication – a specialized cell cycle – is highly associated with cell expansion during tomato fruit growth. However, how endoreduplication coupled with cell size is regulated remains poorly understood. In this study, we identified a zinc finger geneSlPZF1(SolanumlycopersicumPERICARP-ASSOCIATEDZINCFINGER PROTEIN1) that was highly expressed in the pericarp of developing fruits. Plants with alteredSlPZF1expression produced smaller fruits due to the reduction in cell size associated with weakened endoreduplication. OverexpressingSlPZF1delayed cell division phase by enhancing early expression of several key cell cycle regulators includingSlCYCD3;1and two plant specific mitotic cyclin-dependent protein kinase (SlCDKB1andSlCDKB2) in the pericarp tissue. Furthermore, we identified 14 putative SlPZF1 interacting proteins (PZFIs) via yeast two hybrid screening. Several PZFIs, including Pre-mRNA-splicing factor (SlSMP1/PZFI4), PAPA-1-like conserved region family protein (PZFI6), Fanconi anemia complex components (PZFI3 and PZFI10) and bHLH transcription factor LONESOME HIGHWAY (SlLHW/PZFI14), are putatively involved in cell cycle regulation. Our results demonstrate that fruit growth in tomato requires balanced expression of the novel cell size regulatorSlPZF1.
Determinants and Outcomes Associated With Urinary Calcium Excretion in Chronic Kidney Disease
Authors: Liu Jing , Tio Maria Clarissa , Verma Ashish , Schmidt Insa M , Ilori Titilayo O , Knauf Felix , Mc Causland Finnian R , Waikar Sushrut S 
Published: August 2021

Abstract

Context
Abnormalities in calcium metabolism are common in chronic kidney disease (CKD). Diminished urinary calcium excretion may promote vascular calcification and increased urinary calcium excretion may lead to nephrolithiasis and nephrocalcinosis, conditions associated with CKD.

Objective
To study predictors of urinary calcium excretion and its association with adverse clinical outcomes in CKD.

Design, Setting and Patients
This study assessed 3768 nondialysis participants in the Chronic Renal Insufficiency Cohort study from April 2003 to September 2008. Participants were followed up to October 2018.

Exposure
Clinically plausible predictors of urinary calcium excretion and 24-h urinary calcium excretion at baseline.

Main Outcome Measures
Urinary calcium excretion; incident end stage kidney disease (ESKD), CKD progression [50% estimated glomerular filtration rate (eGFR) decline or incident ESKD], all-cause mortality, and atherosclerotic cardiovascular disease events.

Results
eGFR was positive correlated with 24-h urinary calcium excretion. The variables most strongly associated with 24-h urinary calcium excretion in males and females were 24-h urinary sodium (β = 0.19 and 0.28, respectively), serum parathyroid hormone (β = −0.22 and −0.20, respectively), loop diuretics (β = 0.36 and 0.26, respectively), thiazide diuretics (β = −0.49 and −0.53, respectively), and self-identified black race (β = −0.23 and −0.27, respectively). Lower urinary calcium excretion was associated with greater risks of adverse outcomes, but these associations were greatly attenuated or nullified after adjustment for baseline eGFR.

Conclusion
Urinary calcium excretion is markedly lower in individuals with CKD compared to the general population. Determinants of urinary calcium excretion differed between sexes and levels of CKD. Associations between urinary calcium excretion and adverse clinical events were substantially confounded by eGFR.