bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combinations of antibiotics and vonoprazan for the treatment of Helicobacter pylori infections—Exploratory study
Authors: Gunaratne Anoja W , Hamblin Harrison , Clancy Annabel , Magat Aleja Jane Marie C , Dawson Marie Vic M , Tu Jeffrey , Borody Thomas J 
Published: July 2021

AbstractBackgroundVonoprazan fumarate is a novel potassium‐competitive acid blocker more effective in suppressing acid production than proton pump inhibitors (PPIs) and when combined with antibiotics has been used to eradicate Helicobacter pylori (H. pylori) infection. However, it has not yet been examined in an Australian setting. This study aimed to report on the efficacy and safety of vonoprazan‐containing antibiotic combination therapies in the eradication of H. pylori.MethodsA single‐center, exploratory, clinical review of patients 18 years or over, positive for H. pylori on Urea Breath Test (UBT), and/or histopathology who underwent a 10‐day treatment of combination antibiotics plus vonoprazan between January 2017 and September 2019 was conducted. Eleven different combinations of antibiotics that included 2–5 different antibiotics predominantly amoxicillin, rifabutin, levofloxacin, furazolidone, nitazoxanide, and tetracycline were included. The eradication success was based on negative UBT results and/or histopathology results after the treatment. Descriptive statistics were summarized.ResultsOne hundred and fifty‐three patients (Female n = 74, 48%) with a positive for H. pylori were treated with vonoprazan‐containing antibiotic combination therapy during the study period. Of the 153 patients, 48 (31%) had previously failed a PPI‐based H. pylori treatment. Follow‐up was available for 66/153 (43%) patients. In those who completed follow‐up, overall eradication was achieved in 97% (64/66) of patients. In the subgroup of patients treated for the first time, eradication was achieved in 100% (44/44). In those who had failed prior, non‐vonoprazan‐containing treatment, eradication was achieved in 91% (20/22) of patients.ConclusionsVonoprazan‐containing antibiotic therapy is an effective H. pylori eradication treatment. It is capable of achieving 100% efficacy in patients treated for the first time and even 91% efficacy in patients with previous eradication failure. Subsequent studies utilizing a factorial design will be needed to optimize each regimen as most regimens contained more than two antibiotics.
Patient participation during primary health‐care encounters among adult patients with multimorbidity: A cross‐sectional study
Authors: Paukkonen Leila , Oikarinen Anne , Kähkönen Outi , Kyngäs Helvi 
Published: July 2021

AbstractBackgroundPatient participation is essential for achieving high‐quality care and positive outcomes, especially among patients with multimorbidity, which is a major challenge for health care due to high prevalence, care complexity and impact on patients' lives.ObjectiveTo explore the patient participation related to their own care among patients with multimorbidity in primary health‐care settings.MethodsA cross‐sectional survey was conducted among adult multimorbid patients who visited primary health‐care facilities. The key instrument used was the Participation in Rehabilitation Questionnaire. Data representing 125 patients were analysed using various statistical methods.ResultsThe respondents generally felt patient participation to be important, yet provided highly varying accounts regarding the extent to which it was realized by professionals. Information and knowledge and Respect and encouragement were considered the most important and best implemented subcategories of participation. Several patient‐related factors had a statistically significant effect on patient perceptions of participation for all subcategories and as explanatory factors for perceptions of total participation in univariate models. Most patients reported active participation in health‐care communication, positively associated with patient activation and adherence. Gender, perceived health, patient activation and active participation were explanatory factors for total importance of participation in multivariate models, while patient activation was retained for realization of participation.ConclusionsMultimorbid patients require individualized care that promotes participation and active communication; this approach may further improve patient activation and adherence. Poor perceived health and functional ability seemed to be related to worse perceptions of participation.Patient and public involvementThe study topic importance was based on the patients' experiences in author's previous research and the need to develop patient‐centred care.
Arc‐parallel extension in preparation of the rotation of southwest Japan: Tectonostratigraphy and structures of the Lower Miocene Ichishi Group
Authors: Kinoshita Hideki , Yamaji Atsushi 
Published: July 2021

AbstractOpening of the Japan Sea back arc basin was accompanied by extensional tectonics in the drifting southwest Japan arc. Various trends of Early Miocene grabens in the arc suggest multi‐directional rifting, which necessarily involved strike‐slip components of some of basin‐margin faults. However, such components are not well understood. In this work we conducted a field survey in the Early Miocene Ichishi basin on the northern side of the Median Tectonic Line, central southwest Japan. We found that the basin was a compound of grabens that were formed along normal and sinistral strike‐slip faults, the latter of which had northeast–southwest trends. The block faulting in this phase produced basement highs between sub‐basins, which were filled with the lower part of the Ichishi Group. We found a low‐angle angular unconformity at a middle horizon in the group, with which we define the upper and lower part of the group. The upper part onlapped both the basement highs and the lower part. It means that the transtensional basin formation ceased sometime between 18 and 17.5 Ma in the Ichishi area. The Ichishi basin turned subsequently into a sag basin subsided due to normal faulting probably along the Nunobiki‐sanchi‐toen fault zone. The transtension and the basin sag were driven by ENE–WSW extensional stress. This arc‐parallel extension produced grabens various areas including Ichishi in the Early Miocene. The extensional deformation was eventually localized to the deep rift along the Fossa Magna to make the lithosphere under southwest Japan decoupled from that under northeast Japan. The decoupling allowed the rapid rotation of southwest Japan from ~17.5 Ma. The cluster of those grabens around the Ise bay probably determined the southeastern margin of the Kinki triangle.
THE IMPLICATIONS OF HOUSING FOR THE DESIGN OF WEALTH TAXES
Authors: Rotberg Shahar 
Published: July 2021

AbstractHow does housing—an important asset for many households—affect the design of optimal wealth taxes? I analyze the macroeconomic and distributional consequences of wealth taxation using a model with two forms of wealth: capital used by entrepreneurs to produce goods, and housing that provides shelter services. Without housing, taxing wealth instead of capital income would improve the capital allocation and raise welfare. With housing, taxing capital and housing equally would worsen the capital allocation and lower welfare. Instead, wealth should be taxed progressively, exempting most housing, resulting in a worse capital allocation but high welfare gains.
Green banana starch enhances physicochemical and sensory quality of baru almond‐based fermented product with probiotic bacteria
Authors: Coutinho Gabriela Silva Mendes , Ribeiro Alline Emannuele Chaves , Prado Priscylla Martins Carrijo , Oliveira Érica Resende , Careli‐Gondim Ítalo , Oliveira Aryane Ribeiro , Soares Júnior Manoel Soares , Caliari Márcio , Vilas Boas Eduardo Valério de Barros 
Published: July 2021

SummaryThis study aimed to isolate and characterise green banana starch (GBS) and to investigate the effect of adding 0%, 1.5%, 3.0%, 4.5% and 6.0% GBS on physicochemical and sensory properties of a fermented product based on baru almond (Dipteryx alata Vogel) water extract with probiotic bacteria. GBS showed high gelatinisation temperature (73.37 °C), enthalpy (16.61 J g−1) and final viscosity (239.6 RVU). On the contrary, it showed a low tendency to retrograde (67.53 RVU), water solubility (0.02%), water absorption (1.85 g g−1) and gel hardness (6.7 N). Higher addition levels of GBS increased firmness, reduced syneresis and positively affected pH, titratable acid, soluble solids and colour of baru almond‐based fermented products. The incorporation of 4.5% GBS was well accepted and preferred over the control sample (no GBS addition). GBS can be used as a natural thickener. The baru almond‐based fermented product with 4.5% GBS stands out for having potential probiotic properties and for being a promising dairy alternative.
Effect of salt ions on an ultrasonically modified soybean lipophilic protein nanoemulsion
Authors: Wang Diqiong , Qi Baokun , Xu Qingqing , Zhang Shuang , Xie Fengying , Li Yang 
Published: July 2021

SummarySoybean lipophilic proteins (LP) are promising emulsifiers for nanoemulsion delivery systems. We analysed the effect of common salt ions on the stability of nanoemulsion delivery systems that contained ultrasonically modified soybean LP. Moreover, explored the mechanism of influence. The LP nanoemulsions presented large absolute zeta (ζ) potentials at low salt ion concentrations, and their particle size distribution was relatively uniform. The emulsification, encapsulation efficiency and oxidation stability were superior to those of other nanoemulsions. The ultrasonically modified samples presented higher absolute ζ potentials and smaller droplet sizes than the pristine ones and formed uniform protein films at different salt ion concentrations. Therefore, ultrasonication improved the emulsification, encapsulation efficiency and oxidation stability of the emulsions, effectively improve the stability of nano‐delivery systems in different salt ion environments and maximise delivery efficiency at low salt ion concentrations. These results are helpful for the development of LP nanoemulsion systems that are stable at different salt ion concentrations.
Between liberal legislation and preventive political practice: Ecuador’s political reactions to Venezuelan forced migration
Authors: Malo Gabriela 
Published: July 2021

AbstractThe political handling of Venezuelan forced migration in Ecuador has evolved since 2017. This article distinguishes three stages in this evolution. First, from 2017 to mid‐2018, Ecuadorian authorities treated Venezuelan entries as those of other South American citizens. Second, from mid‐2018 to mid‐2019, the Venezuelan exodus was managed as a humanitarian crisis. In the third phase, since mid‐2019, authorities imposed restrictive measures, including a mandatory entry visa. The article further identifies the drivers that have motivated these changes in the reception of Venezuelan migrants, that is the political, social and economic factors that directly or indirectly effected migration management. These factors include both changing foreign policy interests and adjustments in domestic policy. The latter was influenced by strained state capacities and negative trends in public opinion against the backdrop of increasing numbers of Venezuelan migrants and highly mediatized crimes. The article also discusses related literature and provides policy recommendations.
The signaling role of trade credit in bank lending decisions: Evidence from small and medium‐sized enterprises
Authors: Del Gaudio Belinda L. , Sampagnaro Gabriele , Porzio Claudio , Verdoliva Vincenzo 
Published: July 2021

AbstractUsing confidential data at the bank–firm loan‐level, we provide direct evidence of the signaling role of trade credit in bank lending decisions. Especially for firms that are opaque in their relationship with banks, the findings reveal that trade credit ameliorates information asymmetries. We address the questions of whether and, if so, how the presence of trade credit affects banks’ decisions to grant commercial loans. We base the analysis on a sample of small and medium‐sized enterprises to examine suppliers’ informational advantage in screening activities in relation to relationship lending arguments. We provide evidence that supports the role of trade credit as a signaling instrument in lending decisions. More precisely, the analysis suggests that trade credit plays a signaling role, increasing the probability of obtaining a loan. Suppliers bearing credit risk lead banks to lend to firms. Thus, a bank receiving this signal is more likely to grant a loan even though abnormal payment delays are perceived as negative and function as friction during the lending process. This paper has two implications: Banks should use suppliers to signal a “good” type of borrower and for firms, sharing credit information could ameliorate the rationing problems arising in the context of credit asymmetries.
Home‐based primary care: A systematic review of the literature, 2010–2020
Authors: Zimbroff Robert M. , Ornstein Katherine A. , Sheehan Orla C. 
Published: July 2021

AbstractBackgroundAlthough more than seven million older adults struggle or are unable to leave their homes independently, only a small minority access home‐based primary care (HBPC). Despite substantial growth of HBPC, fueled by growing evidence supporting positive patient outcomes and cost savings, the population remains dramatically underserved and many evidence gaps still exist around scope of practice and key issues in care delivery and quality. Understanding the current state of the field is critical to the delivery of high‐quality home‐based care.MethodsWe conducted a systematic search of the peer‐reviewed literature on HBPC, published between January 2010 and January 2020, using Medline, CINAHL, Embase, Web of Science, and Scopus online libraries. All studies were evaluated by two members of the research team, and key findings were extracted.ResultsThe initial search yielded 1730 unique studies for screening. Of these initial results, 1322 were deemed not relevant to this review. Of the 408 studies deemed potentially relevant, 79 were included in the study. Researchers identified five overarching themes: the provision of HBPC, the composition of care teams, HBPC outcomes, the role of telehealth, and emergency preparedness efforts.ConclusionThe need and desire for growth of HBPC has been highlighted by the recent COVID‐19 pandemic. Current research on HBPC finds a diverse scope of practice, successful use of interdisciplinary teams, positive outcomes, and increasing interest in telehealth with many areas ripe for further research.
Post‐injection syringe bacterial contamination of hyaluronic acid fillers
Authors: Dairi Motaz , Sawan Sami , Aref Alaa , Helmi Noof , Abdulmajed Hind , Aldigs Eman 
Published: July 2021

AbstractAimsHyaluronic acid (HA) gel fillers are the most commonly used filler materials for dermal purposes to augment soft tissue due to their superior properties and advantages over other alternative filling materials. One of the key drawbacks associated with the use of fillers is contamination and possible subsequent infection.MethodsA prospective cross‐sectional study conducted in Renew Cosmetic Clinics and King Abdulaziz University, Faculty of Medicine, female section from November 2019 to March 2020.ResultsA total of 50 samples with different concentrations (from five different brands) of hyaluronic acid gel fillers were collected. Samples were taken at four different time points: before injection, immediately after injection, 1 month after injection, and 3 months after injection. The 50 samples were injected into nine different sites and collected from 27 females, aged between 18–55 years. No bacteria were detected in the culture media from any samples from the aerobic and anaerobic culture plates.ConclusionOur study did not find any evidence of contamination associated with the reuse of HA gel fillers regardless of the concentration and the injection site. Applying appropriate sterilization procedure for HA gel fillers extends its usability. There was no correlation between the length of storage time and the risk of contamination.
Psychological distress among the family members of Intensive Care Unit (ICU) patients: A scoping review
Authors: Abdul Halain Azura , Tang Li Yoong , Chong Mei Chan , Ibrahim Noor Airini , Abdullah Khatijah Lim 
Published: July 2021

AbstractAims and objectivesTo map research‐based psychological distress among the family members with patients in the intensive care unit (ICU).BackgroundHaving a loved one in the ICU is a stressful experience, which may cause psychological distress for family members. Depression, anxiety and stress are the common forms of psychological distress associated with ICU patient's family members. Directly or indirectly, psychological distress may have behavioural or physiological impacts on the family members and ICU patient's recovery.DesignThe study was based on the five‐stage methodological framework by Arksey and O'Malley (International Journal of Social Research Methodology, 2005, 8, 19) and were guided by the PRISMA‐ScR Checklist.MethodsA comprehensive and systematic search was performed in five electronic databases, namely the Scopus, Web of Sciences, CINAHL® Complete @EBSCOhost, ScienceDirect and MEDLINE. Reference lists from the screened full‐text articles were reviewed.ResultsFrom a total of 1252 literature screened, 22 studies published between 2010–2019 were included in the review. From those articles, four key themes were identified: (a) Prevalence of psychological distress; (b) Factors affecting family members; (c) Symptoms of psychological distress; and (d) Impact of psychological distress.ConclusionsFamily members with a critically ill patient in ICU show high levels of anxiety, depression and stress. They had moderate to major symptoms of psychological distress that negatively impacted both the patient and family members.Relevance to clinical practiceThe review contributed further insights on psychological distress among ICU patient's family members and proposed psychological interventions that could positively impact the family well‐being and improve the patients' recovery.
Emergency healthcare workers’ preparedness for disaster management: An integrative review
Authors: Almukhlifi Yasir , Crowfoot Gary , Wilson Amanda , Hutton Alison 
Published: July 2021

AbstractBackgroundAround 2 billion people globally were affected by natural disasters between 2008–2018. The World Health Organization requires countries and governments to have disaster plans and emergency health workers ready and prepared at all times.ObjectivesTo conduct an integrative review of literature of emergency healthcare workers’ perceived preparedness for disaster management.MethodologyAn integrative literature review using the PRISMA checklist guidelines was conducted to explore physicians, nurses, emergency medical services and allied medical professionals’ preparedness for disasters. Literature was searched from 2005, published in the English language and from MEDLINE (PubMed), Google Scholar, EMBASE, PsycINFO, SCOPUS, ProQuest and CINAHL databases. Reviews, case reports, clinical audits, editorials and short communications were excluded. Studies were critically appraised using the Mixed Methods Appraisal Tool.ResultsThe initial search yielded 9589 articles. Twenty‐seven articles were included following application of the eligibility criteria. Included studies were geographically diverse including North America, the Middle East and the Asia Pacific. Most studies (n = 24) assessed the knowledge of healthcare workers in general disasters. Studies using the Disaster Preparedness Evaluation Tool reported moderate disaster preparedness and knowledge, while studies using other instruments largely reported inadequate disaster preparedness and knowledge. Regional variations were recorded, with high‐income countries’ reporting a higher perceived preparedness for disasters than low‐income countries.ConclusionThe majority of the emergency healthcare workers appear to have inadequate disaster preparedness. Previous disaster experience and training improved disaster preparedness. Future research should focus on interventions to improve emergency healthcare workers preparedness for disasters.
Real Estate Shocks and Financial Advisor Misconduct
Authors: DIMMOCK STEPHEN G. , GERKEN WILLIAM C. , VAN ALFEN TYSON 
Published: July 2021

ABSTRACTWe test whether personal real estate shocks affect professional misconduct by financial advisors. We use a panel of advisors' home addresses and examine within‐advisor variation relative to other advisors who work at the same firm and live in the same ZIP code. We find a negative relation between housing returns and misconduct. We show that advisors' housing returns explain misconduct against out‐of‐state customers, breaking the link between customer and advisor housing shocks. Furthermore, the results are stronger for advisors with lower career risk from committing misconduct, and for advisors with greater borrowing constraints.
Excessive gestational weight gain during the week prior to delivery as a predictor of maternal life‐threatening complications in preeclamptic women
Authors: Morikawa Mamoru , Saito Yoshihiro , Mayama Michinori , Noshiro Kiwamu , Nakagawa‐Akabane Kinuko , Umazume Takeshi , Chiba Kentaro , Watari Hidemichi 
Published: July 2021

AbstractAimTo investigate the relationship between excessive gestational weight gain during the week prior to delivery (GWG) and severe morbidity and pregnancy termination among pregnant women with preeclampsia (hypertension with proteinuria).MethodsWe compared GWG, laboratory data, and complication(s) between 94 preeclamptic women (preeclampsia group) with singleton pregnancies who delivered at ≥22 gestational weeks and 188 healthy women (control group) with singleton pregnancies undergoing elective cesarean deliveries. The gestational weeks at delivery were matched in the preeclampsia and control groups.ResultsAmong 282 total participants, median of GWG was significantly higher in the preeclampsia group than in the control group (1.6 kg vs. 0.5 kg, p < 0.0001). Furthermore, the GWG cutoff value for the preeclampsia group was 1.6 kg. The odds ratio for morbidity of preeclampsia among the women with GWG ≥1.6 kg at delivery was 12.5 (95% confidence interval, 6.31–24.5). In the preeclampsia group, 47 women with GWG ≥1.6 kg had significantly higher risks of hypoproteinemia, proteinuria, and renal dysfunction than those of 47 women with GWG < 1.6 kg. While, multivariate analysis showed 1.5 kg was a GWG cutoff value for predicting maternal morbidity (p < 0.0001); preeclamptic women with GWG ≥1.5 kg had a significantly higher risk of pulmonary edema than preeclamptic women with GWG < 1.5 kg (odds ratio, 7.77; 95% confidence interval, 1.64–36.7).ConclusionExcessive GWG in women with preeclampsia might be a predictor for severe maternal life‐threatening complications requiring pregnancy termination.