bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA Origami Frameworks Enabled Self‐Protective siRNA Delivery for Dual Enhancement of Chemo‐Photothermal Combination Therapy
Authors: Xu Tingting , Yu Sha , Sun Yao , Wu Shaojun , Gao Di , Wang Mingyang , Wang Zhenzhen , Tian Ye , Min Qianhao , Zhu Jun‐Jie 
Published: October 2021

AbstractAlthough chemotherapy and photothermal therapy are widely used to combat cancer, their efficacy is often limited by multidrug resistance. Small interfering RNAs (siRNAs) have ability to suppress the expression of target genes, which has been extensively employed for combating the multidrug resistance to chemodrugs and hyperthermia in cancer therapy. However, efficient delivery of siRNAs along with chemo‐photothermal agents in vivo is still an enormous challenge. Herein, octahedral DNA origami frameworks (OctDOFs) are constructed as a nanovehicle for precise organization and orchestrated delivery of siRNAs, chemodrugs (doxorubicin, Dox), and photothermal agents (gold nanorods, AuNRs) in combinatorial treatment of cancer. The inner cavity of the rigid OctDOFs structure is able to shield the encapsulated siRNAs during transportation by sterically hindering RNase degradation and protein binding, thus achieving effective downregulation of connective tissue growth factor (CTGF) and heat shock protein 72 (HSP72) for dual sensitization of cancer cells to chemodrugs and hyperthermia. By amplifying chemo‐photothermal therapeutic potency with siRNAs, the proposed OctDOFs exhibited superior cytotoxicity and tumor inhibition efficacy in vitro and in vivo. This nanovehicle creates a promising siRNA delivery platform for precise medication and combination therapy.
Nanospatial Charge Modulation of Monodispersed Polymeric Microsphere Photocatalysts for Exceptional Hydrogen Peroxide Production
Authors: Tian Qiang , Jing Lingyan , Ye Sheng , Liu Junxue , Chen Ruotian , Price Cameron‐Alexander Hurd , Fan Fengtao , Liu Jian 
Published: October 2021

AbstractPhotocatalysis offers a sustainable strategy for hydrogen peroxide (H2O2) production, which is an essential oxidant and emerging energy carrier in modern chemical industry. The development of polymer‐based photocatalysts to produce H2O2 has great potential but is limited by lower efficiency due to the limitation of light utilization and the low charge separation efficiency. Herein, a series of monodispersed mesoporous resorcinol‐formaldehyde resin spheres (MRFS) are reported with a rational designed spatial charge distribution, exhibiting wide light absorption with a solar‐to‐chemical conversion (SCC) efficiency of 1.1%. Surface photovoltage microscopy (SPVM) measurements unraveled the charge separation in nanospace with uneven distribution of donor (D) and acceptor (A) sites. A density functional theory (DFT) calculation elucidated the origin of photogenerated electrons and holes. Moreover, MRFS demonstrates photocatalytic water oxidation ability. The findings in this work open a new avenue for the development of porous polymeric photocatalysts toward highly efficient solar energy conversion.
Confidence‐driven weighted retraining for predicting safety‐critical failures in autonomous driving systems
Authors: Stocco Andrea , Tonella Paolo 
Published: October 2021

AbstractSafe handling of hazardous driving situations is a task of high practical relevance for building reliable and trustworthy cyber‐physical systems such as autonomous driving systems. This task necessitates an accurate prediction system of the vehicle's confidence to prevent potentially harmful system failures on the occurrence of unpredictable conditions that make it less safe to drive. In this paper, we discuss the challenges of adapting a misbehavior predictor with knowledge mined during the execution of the main system. Then, we present a framework for the continual learning of misbehavior predictors, which records in‐field behavioral data to determine what data are appropriate for adaptation. Our framework guides adaptive retraining using a novel combination of in‐field confidence metric selection and reconstruction error‐based weighing. We evaluate our framework to improve a misbehavior predictor from the literature on the Udacity simulator for self‐driving cars. Our results show that our framework can reduce the false positive rate by a large margin and can adapt to nominal behavior drifts while maintaining the original capability to predict failures up to several seconds in advance.
Project Recuerdo: Honoring Latinx Families’ Knowledge Within the School
Authors: Lopez Michelle , Butvilofsky Sandra A. , Le Khanh , Gumina Deena 
Published: October 2021

AbstractThe authors describe a culturally sustaining bilingual family engagement project that draws upon Latinx families’ experiential and cultural wealth and integrates that knowledge within the literacy curriculum of a bilingual fourth grade classroom. Through the use of monthly writing prompts, Project Recuerdo, engages families in sharing stories that demonstrate cultural, linguistic, and historical knowledge with the child, teacher, and wider community. This form of family engagement counters deficit orientations towards diverse families, especially Mexican American families, as problems to fix, and instead honors the wealth of knowledge families have and integrates it within the curriculum. Through the analysis of the bilingual journal entries, related classroom artifacts, and family focal groups, the authors validate the importance of learning with and from diverse families; and detail the process for planning the implementation of the family project. Authors provide suggestions for teacher self‐reflection and possible writing prompts to engage families.
Management of intertarsal septic arthritis in an ostrich (Struthio camelus)
Authors: Peel Melanie J. , Torres Rodrigo S. Garcés , Ivančić Marina , Hernández Benjamín E. Alcántar 
Published: October 2021

AbstractA 7‐year‐old female ostrich (Struthio camelus) presented with lameness, left intertarsal joint swelling and a healing wound on the caudomedial aspect of the joint. Synovial culture revealed Corynebacterium species and radiographs were consistent with progressive septic arthritis. Multiple treatments were attempted including through‐and‐through joint lavage, intra‐articular antibiotics, caudomedial arthrotomy, and regional limb perfusion in conjunction with systemic antibiotics and analgesia. Euthanasia was ultimately performed due to prolonged recumbency and poor prognosis. This report describes novel therapies and a surgical approach utilized for treatment of intertarsal septic arthritis in an ostrich and exemplifies the poor prognosis described in other species presenting with non‐responsive septic arthritis of critical joints.
Clinical features, imaging characteristics, genetic investigation and histopathologic findings in a Chihuahua dog with Lafora disease
Authors: Menchetti Marika , Antinori Lucia , Serra Giulia Dalla , Bertolini Giovanna , Rosati Marco 
Published: October 2021

AbstractA nine‐year‐old female spayed Chihuahua dog had developed hypnic jerks and progressive myoclonic seizures three months before presentation. Neurological examination showed mental depression and spontaneous or reflex myoclonus. Magnetic resonance imaging findings were consistent with cerebral cortical atrophy and mild cranio‐cervical junction abnormalities. Genetic testing revealed a homozygous NHCLR1 gene mutation, consistent with Lafora disease. Antiepileptic treatment was unsuccessful. Postmortem brain histopathological examination showed a diffuse combination of perikaryal, axonal and/or dendritic accumulation of periodic acid Schiff‐positive cytoplasmic polyglucosan bodies (Lafora bodies), in particular, in the cerebellar cortex. Lafora disease should be considered in the differential diagnosis of late‐onset myoclonus seizures in Chihuahua dogs. Genetic testing of relatives of affected cases is recommended in order to identify carriers and dogs at the preclinical disease stage, to establish the frequency of the mutation in the Chihuahua population, and ultimately to decrease the frequency of this fatal disease.
How to strike a conformational balance in protein force fields for molecular dynamics simulations?
Authors: Kang Wei , Jiang Fan , Wu Yun‐Dong 
Published: October 2021

AbstractMolecular dynamics (MD) simulation is a powerful tool for exploring the conformational energy landscape of proteins, and the reliability of MD results is crucially dependent on the underlying force field (FF). An accurate FF capable of producing balanced distributions of diverse conformations at multiple levels has been a long‐sought goal. Towards this, several decades of joint efforts have been made to address FF deficiencies, manifested by conformational biases at different levels (local conformations, secondary structures, and global extendedness of polypeptide chain). We first present the major FF biases, then review the strategies to address them separately. Specifically, both nonresidue‐specific and residue‐specific strategies for torsional parameter optimization have been applied to achieve local conformation and secondary structure balances. Significant improvements can be gained with residue‐specific torsional parameters especially when explicit dihedral couplings are considered. Further, the additional balance between protein–protein and protein–water interactions has been optimized via multiple ways to reproduce the global extendedness of polypeptide chains, especially for unfolded or disordered proteins. This review aims to summarize the most valuable experience and lessons gained from the past, which, we hope, can facilitate further improvements of both classical FFs and more sophisticated models such as polarizable FFs.This article is categorized under:
Molecular and Statistical Mechanics > Molecular Dynamics and Monte‐Carlo Methods
Molecular and Statistical Mechanics > Molecular Mechanics
2d TQFTs and baby universes
Authors: Gardiner John , Megas Stathis 
Published: October 2021

Abstract
In this work, we extend the 2d topological gravity model of [1] to have as its bulk action any open/closed TQFT obeying Atiyah’s axioms. The holographic duals of these topological gravity models are ensembles of 1d topological theories with random dimension. Specifically, we find that the TQFT Hilbert space splits into sectors, between which correlators of boundary observables factorize, and that the corresponding sectors of the boundary theory have dimensions independently chosen from different Poisson distributions. As a special case, we study in detail the gravity model built from the bulk action of 2d Dijkgraaf-Witten theory, with or without end-of-the-world branes, and for arbitrary finite group G. The dual of this Dijkgraaf-Witten gravity model can be interpreted as a 1d topological theory whose Hilbert space is a random representation of G and whose aforementioned sectors are labeled by the irreducible representations of G.These holographic interpretations of our gravity models require projecting out negative-norm states from the baby universe Hilbert space, which in [1] was achieved by the (only seemingly) ad hoc solution of adding a nonlocal boundary term to the bulk action. In order to place their solution in the completely local framework of a TQFT with defects, we couple the boundaries of the gravity model to an auxiliary 2d TQFT in a non-gravitational (i.e. fixed topology) region. In this framework, the difficulty of negative-norm states can be remedied in a local way by the introduction of a defect line between the gravitational and non-gravitational regions. The gravity model is then holographically dual to an ensemble of boundary conditions in an open/closed TQFT without gravity.
Einsatz von Albumin
Authors: Mayerhöfer Timo , Wiedermann Christian J. , Joannidis Michael 
Published: October 2021

ZusammenfassungDie Saline vs. Albumin Fluid Evaluation (SAFE) Studie hat gezeigt, dass der Einsatz von Albumin als Infusionslösung im Bereich der Volumentherapie fast überall sicher ist. Eine Ausnahme stellt hypoonkotisches Albumin beim Schädel-Hirn-Trauma dar. Während für Patientinnen und Patienten mit Leberzirrhose klare Indikationen existieren, fehlen für andere Einsatzgebiete noch große Studien, die einen klinisch relevanten Vorteil jenseits der hämodynamischen Wirksamkeit zweifelsfrei zeigen konnten und damit einen breiteren Einsatz rechtfertigen würden. Bei der „Large-volume“-Parazentese, der spontanen bakteriellen Peritonitis, aber auch beim hepatorenalen Syndrom ist der Einsatz von Albumin aufgrund eines klinischen Benefits in randomisierten kontrollierten Studien klar empfohlen und etabliert. Beim septischen Schock kann ein Einsatz von Albumin in Erwägung gezogen werden, wobei sich zwei große Studien zu dieser Fragestellung in Deutschland und Italien noch in der Rekrutierungsphase befinden. Für viele Einsatzgebiete in der Volumentherapie gilt, dass Albumin vor allem dann eingesetzt werden kann, wenn andere Maßnahmen zur hämodynamischen Stabilisierung bereits ausgeschöpft sind. Das gilt sowohl für die Volumengabe bei Hypovolämie als auch für das konservative Volumenmanagement einschließlich der sog. Deresuscitation-Phase. Inwieweit die Korrektur einer ausgeprägten Hypoalbuminämie durch Gabe von exogenem Albumin auch das schlechtere Outcome solcher Patientinnen und Patienten verbessert, ist ebenfalls Teil laufender Studien. Auf dem Weg zu einem Mehr an individualisierter Therapie kann in Zukunft die Hypoalbuminämie bei Entscheidungen für oder gegen einen Einsatz von intravenösen Albuminlösungen in der Volumentherapie eine wichtige Rolle einnehmen.
The consequences of out-of-hours hip fracture surgery: insights from a retrospective nationwide study
Authors: Forssten Maximilian Peter , Mohammad Ismail Ahmad , Borg Tomas , Cao Yang , Wretenberg Per , Bass Gary Alan , Mohseni Shahin 
Published: October 2021

Abstract
Purpose
The study aimed to investigate the association between out-of-hours surgery and postoperative mortality in hip fracture patients. Furthermore, internal fixation and arthroplasty were compared to determine if a difference could be observed in patients operated with these techniques at different times during the day.

Methods
All patients above 18 of age years in Sweden who underwent hip fracture surgery between 2008 and 2017 were eligible for inclusion. Pathological fractures, non-operatively managed fractures, or cases whose time of surgery was missing were excluded. The cohort was subdivided into on-hour (08:00–17:00) and out-of-hours surgery (17:00–08:00). Poisson regression with adjustments for confounders was used to evaluate the association between out-of-hours surgery and both 30-day and 90-day postoperative mortality.

Results
Out-of-hours surgery was associated with a 5% increase in the risk of both 30-day [adj. IRR (95% CI) 1.05 (1.00–1.10), p = 0.040] and 90-day [adj. IRR (95% CI) 1.05 (1.01–1.09), p = 0.005] mortality after hip fracture surgery compared to on-hour surgery. There was no statistically significant association between out-of-hours surgery and postoperative mortality among patients who received an internal fixation. Arthroplasties performed out-of-hours were associated with a 13% increase in 30-day postoperative mortality [adj. IRR (95% CI) 1.13 (1.04–1.23), p = 0.005] and an 8% increase in 90-day postoperative mortality [adj. IRR (95% CI) 1.08 (1.01–1.15), p = 0.022] compared to on-hour surgery.

Conclusion
Out-of-hours surgical intervention is associated with an increase in both 30- and 90-day postoperative mortality among hip fracture patients who received an arthroplasty, but not among patients who underwent internal fixation.
3D tumor angiogenesis models: recent advances and challenges
Authors: Bhat Sharath M. , Badiger Vaishnavi A. , Vasishta Sampara , Chakraborty Juhi , Prasad Seetharam , Ghosh Sourabh , Joshi Manjunath B. 
Published: October 2021

AbstractThe development of blood vessels, referred to as angiogenesis, is an intricate process regulated spatially and temporally through a delicate balance between the qualitative and quantitative expression of pro and anti-angiogenic molecules. As angiogenesis is a prerequisite for solid tumors to grow and metastasize, a variety of tumor angiogenesis models have been formulated to better understand the underlying mechanisms and associated clinical applications. Studies have demonstrated independent mechanisms inducing angiogenesis in tumors such as (a) HIF-1/VEGF mediated paracrine interactions between a cancer cell and endothelial cells, (b) recruitment of progenitor endothelial cells, and (c) vasculogenic mimicry. Moreover, single-cell sequencing technologies have indicated endothelial cell heterogeneity among organ systems including tumor tissues. However, existing angiogenesis models often rely upon normal endothelial cells which significantly differ from tumor endothelial cells exhibiting distinct (epi)genetic and metabolic signatures. Besides, the existence of intra-individual variations necessitates the development of improved tumor vascular model systems for personalized medicine. In the present review, we summarize recent advancements of 3D tumor vascular model systems which include (a) tissue engineering-based tumor models; (b) vascular organoid models, and (c) organ-on-chips and their importance in replicating the tumor angiogenesis along with the associated challenges to design improved models.
Seasonal variations in the synoptic climatology of air pollution in Birmingham, UK
Authors: Hodgson Edward C. , Phillips Ian D. 
Published: October 2021

AbstractA synoptic typing approach was undertaken to examine the seasonal relationship (winter versus summer) between air mass types and pollutant concentrations of O3, PM10, NOx, NO2 and CO in Birmingham, UK, from 2000 to 2015. Daily means of seven surface meteorological variables were entered into a P-mode principal component analysis. Three principal components explained 72.2% (72.9%) of the variance in winter (summer). Cluster analysis was used to group together days with similar PC scores and thus similar meteorological conditions. Six clusters provided the best air mass classification in both seasons. High pollutant concentrations were associated with anticyclonic types. In particular, tropical (polar) continental air mass type was most likely to produce extremely high concentrations in summer (winter). In winter, a sequence of Polar Continental (cool and humid) and Binary Mid-latitude Anticyclonic Maritime—Sub-Polar Cyclonic Maritime (cold and dry) induced severe pollution episodes in all pollutants. Whilst the mean duration of severe pollution episodes varied little between winter and summer (O3 was an exception, with severe episodes lasting 20% longer in summer), high pollutant extremes were more common in winter. This was due to more favourable meteorological conditions (e.g. temperature inversions) and increased anthropogenic emissions during the cold season.
Geophysical methods help to assess potential groundwater extraction sites
Authors: Wiederhold Helga , Kallesøe Anders Juhl , Kirsch Reinhard , Mecking Rebekka , Pechnig Renate , Skowronek Frank 
Published: October 2021

AbstractComplex geology in glacial terrain makes groundwater exploration challenging for water supply companies. Abrupt lateral changes of geological conditions, for example, raise the risk of unsuccessful exploration drilling. At some locations, local water supply companies experience a large number of dry wells, raising the need for better exploration approaches. The use of geophysical techniques enables the detection and characterization of subsurface structures in terms of aquifers and aquitards.We present two examples in which seismic and resistivity methods are combined for subsurface characterization. A thrust structure is detected in the Varde study area in Denmark and a channel structure is mapped in the Hamburg-Sülldorf study area in Germany. The different imaging characteristics of seismic P‑ and S‑waves are demonstrated. The combination of seismic and resistivity methods enables delineating groundwater-bearing and groundwater-barrier layers down to a depth of 150 m.
The impact of the COVID-19 pandemic on global neurosurgical education: a systematic review
Authors: Jain Raunak , Carneiro Raquel Alencastro Veiga Domingues , Vasilica Anca-Mihaela , Chia Wen Li , de Souza Abner Lucas Balduino , Wellington Jack , Kumar Niraj S. 
Published: October 2021

Abstract
The COVID-19 pandemic has disrupted neurosurgical training worldwide, with the shutdown of academic institutions and the reduction of elective surgical procedures. This impact has disproportionately affected LMICs (lower- and/or middle-income countries), already burdened by a lack of neurosurgical resources. Thus, a systematic review was conducted to examine these challenges and innovations developed to adapt effective teaching and learning for medical students and neurosurgical trainees. A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P) and The Cochrane Handbook of Systematic Reviews of Interventions. MEDLINE, PubMed, Embase and Cochrane databases were accessed, searching and screening literature from December 2019 to 5th December 2020 with set inclusion and exclusion criteria. Screening identified 1254 articles of which 26 were included, providing data from 96 countries. Twenty-three studies reported transition to online learning, with 8 studies also mentioned redeployment into COVID wards with 2 studies mentioning missed surgical exposure as a consequence. Of 7 studies conducted in LMICs, 3 reported residents suffering financial insecurities from reduced surgical caseload and recession. Significant global disruption in neurosurgical teaching and training has arisen from the COVID-19 pandemic. Decreased surgical exposure has negatively impacted educational provision. However, advancements in virtual technology have allowed for more affordable, accessible training especially in LMICs. Using this, initiatives to reduce physical and mental stress experienced by trainees should be paramount.
Macroinvertebrate species occupancy frequency distribution patterns in eutrophic lakes
Authors: Suhonen Jukka , Paasivirta Lauri , Rantala Markus J. , Jukka Salmela , Suutari Erna 
Published: October 2021

AbstractMetacommunity models describe species occupancy frequency distribution (hereinafter ‘SOFD’). Our goal is to present how the differences in eight macroinvertebrate orders dispersal ability affect SOFD patterns. A total of 293 species from eight macroinvertebrate orders were observed in 14 eutrophic lakes in southern Finland. Species occupancy ranged from 1 to 14. About 30% (89 out of 293) of the species were found in only one lake, yielding a surprisingly high number of rare species. So, there were few widely distributed common species and numerous rare species with a restricted distribution. Combined data from eight macroinvertebrate orders supported the bimodal truncated SOFD pattern. Similarly, the low dispersal ability orders, watermites and mayflies, fitted the bimodal truncated SOFD pattern. However, bimodal symmetric SOFD pattern also fitted relatively well to the dragonflies and damselflies with high dispersal ability. It seems that differences in dispersal ability among different macroinvertebrate orders may partly explain observed differences. Moreover, our results supported slightly more a niche-based model rather than a metapopulation dynamics model in eutrophic lakes littoral macroinvertebrate metacommunities. Our results highlight that the dispersal ability is important trait for species conservation in patchily distributed habitat.