bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS PENGGUNAAN LAYANAN VESSEL TRAFFIC SYSTEM TERHADAP KESELAMATAN PELAYARAN DI ALUR PELAYARAN BARAT SURABAYA PELINDO 3
Authors: Mudiyanto Mudiyanto , Febriana Elva 
Published: March 2021

<p><em>Vessel Traffic System</em> (VTS) merupakan sistem komunikasi yang dapat memberikan informasi dan pesan bagi kapal. fasilitas yang terdapat dalam VTS yaitu menyediakan layanan <em>traffic organization service</em> yaitu layanan yang memberikan pengaturan pergerakan lalu lintas kapal didalam wilayah Alur Pelayaran Barat Surabaya (APBS) Tujuan dari penelitian ini adalah untuk mengetahui Implementasi aturan penggunaan layanan VTS terhadap keselamatan pelayaran di alur pelayaran Surabaya. Manfaat penelitian Penelitian yang akan menghasilkan analisis penggunaaan layanan VTS terhadap keselamatan pelayaran. Metodologi penelitian ini adalah dengan metode kuantitatif jumlah responden 109 dengan hasil penelitian nilai R berganda 0.944 bahwa layanan INS dan alat penunjang navigasi berpengaruh sangat kuat terhadap keselamatan pelayaran. <strong></strong></p><strong>Kata Kunci:</strong> Vessel Traffic System, Keselamatan Pelayaran
Topological superconductivity and Majorana states in low-dimensional systems
Authors: Val’kov V V , Shustin M S , Aksenov S V , Zlotnikov A O , Fedoseev A D , Mitskan V A , Kagan M Yu 
Published: March 2021

Abstract
We discuss the properties of topologically nontrivial superconducting phases and the conditions for their realization in condensed matter, the criteria for the appearance of elementary Majorana-type excitations in solids, and the corresponding principles and experimental methods for identifying Majorana bound states (MBSs). Along with the well-known Kitaev chain and superconducting nanowire (SW) models with spin–orbit coupling in an external magnetic field, we discuss models of quasi-two-dimensional materials in which MBSs are realized in the presence of noncollinear spin ordering. For finite-length SWs, we demonstrate a cascade of quantum transitions occurring with a change in the magnetic field, accompanied by a change in the fermion parity of the ground state. The corresponding anomalous behavior of the magnetocaloric effect can be used as a tool for identifying MBSs. We devote considerable attention to the analysis of the transport characteristics of devices that contain topologically nontrivial materials. The results of studying the conductance of an Aharonov–Bohm ring whose arms are connected by an SW are discussed in detail. An important feature of this device is the appearance of Fano resonances in the dependence of conductance on the magnetic field when the SW is in a topologically nontrivial phase. We establish a relation between the characteristics of such resonances and the spatial structure of the lowest-energy SW state. The conditions for the occurrence of an MBS in the phase of the coexistence of chiral d + id superconductivity and 120-degree spin ordering are determined in the framework of the
t – J – V
model on a triangular lattice. We take electron–electron interactions into account in discussing the topological invariants of low-dimensional superconducting materials with noncollinear spin ordering. The formation of Majorana modes in regions with an odd value of a topological ℤ invariant is demonstrated. The spatial structure of these excitations in the Hubbard fermion ensemble is determined.
Simple-Structured OLEDs Incorporating Undoped Phosphorescent Emitters Within Non-Exciplex Forming Interfaces: Towards Ultraslow Efficiency Roll-Off and Low Driving Voltage for Indoor R/G/B Illumination
Authors: Xu Ting , Yi Ruichen , Zhu Chunqin , Lin Mingquan 
Published: March 2021

To meet the requirement of indoor R/G/B monochrome illumination a simplified OLEDs structure and fabrication process must occur. Herein, a design philosophy of low efficiency roll-off and simple-structure OLEDs incorporating R/G/B phosphorescent ultrathin non-doped emissive layers (EMLs) within non-exciplex forming interfaces a luminescent system by a direct charge trapping mechanism has been reported, which uses bis(2-methyldibenzo[f,h]-quinoxaline)(acetylacetonate)iridium(III) (MDQ)2Ir(acac), bis(3-phenylpyridin-e)iridium(III) (Ir(ppy)3), and bis(3,5-difluoro-2 -(2-pyridyl)phenyl-(2-carboxypyridyl) iridiumII) (Firpic) as R/G/B luminescent dyes, respectively. Although the recombination zone is narrow in the designed OLEDs, the efficiency roll-off of the designed OLEDs are unexpectedly slow, due to stable charge trapping of the emitters and are refrained from concentration quenching in relatively low current density, but the luminance meets the requirement of indoor lighting. With a low threshold voltage of 2.9/2.9/3.5 V, the designed R/G/B phosphorescent OLEDs show an efficiency roll-off as low as 7.6/3.2/4.3% for indoor luminance from 10 cd/m2 to 1,000 cd/m2, respectively. The perspective of R/G/B luminescent dyes on luminous efficiency, chromaticity coordinate drifts, efficiency roll-off, and direct charge trapping has been thoroughly studied. Therefore, our research may help to further develop ideal indoor lighting using a simplified undoped R/G/B OLEDs structure with simultaneous ultraslow efficiency roll-off, low threshold voltage, simplified fabrication process, low reagent consumption, and cost.
Aptamer Turn-On SERS/RRS/Fluorescence Tri-mode Platform for Ultra-trace Urea Determination Using Fe/N-Doped Carbon Dots
Authors: Li Chongning , Li Jiao , Liang Aihui , Wen Guiqing , Jiang Zhiliang 
Published: March 2021

Sensitive and selective methods for the determination of urea in samples such as dairy products are important for quality control and health applications. Using ammonium ferric citrate as a precursor, Fe/N-codoped carbon dots (CDFeN) were prepared by a hydrothermal procedure and characterized in detail. CDFeN strongly catalyzes the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H2O2 to turn on an indicator molecular reaction, forming an oxidized tetramethylbenzidine (TMBox) probe with surface-enhanced Raman scattering, resonance Rayleigh scattering, and fluorescence (SERS, RRS, and FL) signals at 1,598 cm−1, 370 nm, and 405 nm, respectively. The urea aptamer (Apt) can turn off the indicator reaction to reduce the tri-signals, and the addition of urea turns on the indicator reaction to linearly enhance the SERS/RRS/FL intensity. Thus, a novel Apt turn-on tri-mode method was developed for the assay determination of ultra-trace urea with high sensitivity, good selectivity, and accuracy. Trace adenosine triphosphate and estradiol can also be determined by the Apt-CDFeN catalytic analytical platform.
Disseminated Talaromyces marneffei Infection in a Non-HIV Infant With a Homozygous Private Variant of RELB
Authors: Ding Xiaofang , Huang Han , Zhong Lili , Chen Min , Peng Fang , Zhang Bing , Cui Xinyu , Yang Xiu-An 
Published: March 2021

ObjectiveThis study presents a relatively rare case of disseminated Talaromyces marneffei (T. marneffei) infection in an HIV-negative patient.MethodsAn 8-month-old girl was hospitalized because of uncontrollable fever and cough for 6 days. Routine laboratory tests, biochemical detection, immunological tests, pathogenic examination, and imaging inspection were performed. Genetic tests of trio whole genome sequencing (Trio-WES), trio copy number sequencing (Trio-CNVseq), and Sanger sequencing were conducted to identify pathogenic variants. In silico analysis of the sequence alignment and structural modeling results was carried out to study the possible pathogenicity of the identified variant. Western blotting was performed to investigate the expression of the identified gene at the protein level.ResultsEnhanced CT and MRI scanning demonstrated thymic dysplasia, diffuse pulmonary and liver nodules, and many balloon-like air sacs in both lungs. The white blood cell count, neutrophil count, and neutrophil ratio were normal or elevated. The patient was HIV-negative and bone marrow and blood culture showed T. marneffei infection. Total lymphocyte count, CD3+ T lymphocyte count, CD3+CD4+ T lymphocyte count, CD3+CD8+ T lymphocyte count, and NK cell count decreased, while the number of CD19 positive B cells increased. However, the ratio of CD3+CD4+:CD3+CD8+ T cells increased. Trio-WES identified a homozygous private variant of NM_006509: c.400_c.401insAGC/p.Lys134 delinsLysGln in RELB and Sanger sequencing validated the result. Structural modeling indicated that the variant may be pathogenic. Reverse transcription-polymerase chain reaction and Western blot analysis showed that the expression of RelB in the patient was lower than that in the healthy controls at mRNA and protein levels.ConclusionThis is the first report on disseminated T. marneffei infection in a patient with a homozygous private variant of RELB.
Prevented Sudden Cardiac Death and Neurologic Recovery in Inherited Heart Diseases
Authors: Hernández del Rincón Juan P. , Olmo Conesa Mari C. , Rodríguez Serrano Ana , García Pulgar Helena , López Cuenca David , Muñoz Esparza Carmen , Navarro Peñalver Marina , Santos Mateo Juan José , Nicolás Rocamora Elisa , Gil Ortuño Cristina , Sabater-Molina María , Gimeno Blanes Juan Ramón , Pastor Quirante Francisco 
Published: March 2021

Introduction: Inherited cardiovascular diseases are an important cause of sudden cardiac death (SD). The use of risk scores identify high risk patients who would benefit from an implantable cardioverter-defibrillators (ICDs). The development of automated devices for out-of-hospital cardiac arrest improves early resuscitation. The objective of the study is to quantify prevented SD and the neurological recovery of patients with inherited cardiovascular diseases.Methods: Two hundred fifty-seven cases of SD (age 42 ± 18 years, 79.4% men) of non-ischemic cardiac cause were prospectively collected during the study period (2009–17). Fifty three (20.6%) had a resuscitated cardiac arrest (RCA) (age 40 ± 18 years, 64.2% male). Epidemiological, clinical and autopsy aspects were analyzed. Prevented SD was defined as a combination of RCA and appropriate ICD therapy cases.Results: An autopsy was performed in 157/204 (77.0%) cases who died. There were 19 (12.1%) cases with a negative autopsy. The diagnosis of cardiomyopathy and channelopathy was 58.0 and 18.7%, respectively. Female sex and confirmed or suspected channelopathy were associated with successful resuscitation. The percentage of prevented SD remained low during the study period (mean 35.6%). 60.4% of RCA cases presented good neurological outcome. There was no association between neurological recovery and therapeutic hypothermia, but there was association with time of resuscitation (min).Conclusion: A fifth part of non-ischemic cardiac arrests were resuscitated. Female sex and channelopathies were more prevalent among RCA. Two thirds of RCA had a good neurological recovery.
Donepezil Ameliorates Pulmonary Arterial Hypertension by Inhibiting M2-Macrophage Activation
Authors: Qiu Haihua , Zhang Yibo , Li Zhongyu , Jiang Ping , Guo Shuhong , He Yi , Guo Yuan 
Published: March 2021

Background: The beneficial effects of parasympathetic stimulation in pulmonary arterial hypertension (PAH) have been reported. However, the specific mechanism has not been completely clarified. Donepezil, an oral cholinesterase inhibitor, enhances parasympathetic activity by inhibiting acetylcholinesterase, whose therapeutic effects in PAH and its mechanism deserve to be investigated.Methods: The PAH model was established by a single intraperitoneal injection of monocrotaline (MCT, 50 mg/kg) in adult male Sprague-Dawley rats. Donepezil was administered via intraperitoneal injection daily after 1 week of MCT administration. At the end of the study, PAH status was confirmed by echocardiography and hemodynamic measurement. Testing for acetylcholinesterase activity and cholinergic receptor expression was used to evaluate parasympathetic activity. Indicators of pulmonary arterial remodeling and right ventricular (RV) dysfunction were assayed. The proliferative and apoptotic ability of pulmonary arterial smooth muscle cells (PASMCs), inflammatory reaction, macrophage infiltration in the lung, and activation of bone marrow-derived macrophages (BMDMs) were also tested. PASMCs from the MCT-treated rats were co-cultured with the supernatant of BMDMs treated with donepezil, and then, the proliferation and apoptosis of PASMCs were evaluated.Results: Donepezil treatment effectively enhanced parasympathetic activity. Furthermore, it markedly reduced mean pulmonary arterial pressure and RV systolic pressure in the MCT-treated rats, as well as reversed pulmonary arterial remodeling and RV dysfunction. Donepezil also reduced the proliferation and promoted the apoptosis of PASMCs in the MCT-treated rats. In addition, it suppressed the inflammatory response and macrophage activation in both lung tissue and BMDMs in the model rats. More importantly, donepezil reduced the proliferation and promoted the apoptosis of PASMCs by suppressing M2-macrophage activation.Conclusion: Donepezil could prevent pulmonary vascular and RV remodeling, thereby reversing PAH progression. Moreover, enhancement of the parasympathetic activity could reduce the proliferation and promote the apoptosis of PASMCs in PAH by suppressing M2-macrophage activation.
Associations of Circulating Osteoglycin With Bone Parameters and Metabolic Markers in Patients With Diabetes
Authors: Starup-Linde Jakob Kau , Viggers Rikke , Langdahl Bente , Gregersen Soeren , Lykkeboe Simon , Handberg Aase , Vestergaard Peter 
Published: March 2021

ObjectiveCirculating osteoglycin may facilitate the crosstalk between bone and pancreas to empower adaptation of bone mass to whole body energy balance. We aimed to examine whether osteoglycin is associated with bone and metabolic parameters and if osteoglycin levels differ between patients with type 1 and 2 diabetes (T1D and T2D).Design and methodsA cross-sectional study of 190 patients with diabetes mellitus and stable hemoglobin A1c (HbA1c) (97 T1D and 93 T2D) was conducted. S-osteoglycin was analyzed by ELISA. Unpaired t-tests were performed to test differences between patients with T1D and T2D and linear regression analyses were performed to investigate associations between osteoglycin, glycemic markers, bone turnover markers and characteristics.ResultsS-osteoglycin did not differ between patients with T1D and T2D (p=0.10). No associations were present between osteoglycin and age, gender, microvascular complications, HbA1c, or plasma glucose in T1D or T2D patients (p&gt;0.05 for all). S-osteoglycin was not associated with levels of bone turnover markers (C-terminal cross-linked telopeptide of type-I collagen (CTX), P-procollagen type 1 amino terminal propeptide (P1NP), P-osteocalcin (OC), P-sclerostin, S-osteoprotegerin (OPG) or S-Receptor Activator of Nuclear factor Kappa beta Ligand (RANKL)) in neither T1D or T2D patients (p&gt;0.05 for all).ConclusionOsteoglycin levels were similar in T1D and T2D patients. Osteoglycin did not correlate with glucose, HbA1c or any other biochemical marker of bone turnover. Thus, we did not find evidence supporting the existence of an osteoglycin-bone-pancreas axis.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT01870557.
Homozygous of MRP4 Gene rs1751034 C Allele Is Related to Increased Risk of Intravenous Immunoglobulin Resistance in Kawasaki Disease
Authors: Wang Yanfei , Xu Yufen , Huang Ping , Che Di , Wang Zhouping , Huang Xijing , Xie Xiaofei , Li Wei , Zhang Li , Gu Xiaoqiong 
Published: March 2021

Background: Kawasaki disease (KD) is a systemic vasculitis in childhood, which mainly causes damage to coronary arteries, and intravenous immunoglobulin (IVIG) is the initial therapy. IVIG resistance increased risk of coronary complication in KD. And genetic background is involved in the occurrence of IVIG resistance. Our previous study indicated the susceptibility of Multi-drug resistance protein 4 (MRP4) SNPs to KD. This study was to clarify the relationship between MRP4 polymorphisms and IVIG resistance.Methods: We genotyped the six polymorphisms of MRP4 gene in 760 cases of KD using Taqman methods.Results: Among the six polymorphisms, only the rs1751034 polymorphism was significantly associated with IVIG resistance in KD [CC vs. TT: adjusted odds ratio (OR) = 2.54, 95% confidence interval (CI) = 1.21–5.34; CC vs. TT/TC: adjusted OR = 2.33, 95% CI = 1.12–4.83, p = 0.023]. Combined analysis of three polymorphisms indicated that patients with 3–6 risk genotypes exhibited significantly elevated risk of IVIG resistance, when compared with those with 0–2 risk genotypes (adjusted OR = 1.52, 95% CI = 1.04–2.22, p = 0.0295). Stratified analysis revealed that in term of age and gender, rs1751034 CC carriers were associated with increased risk of IVIG resistance in those aged ≤ 60 months (adjusted OR = 2.65, 95% CI = 1.23–5.71, p = 0.0133). The presence of three or more risk genotypes was significantly associated with risk of IVIG resistance in children younger than 5 years of age and males.Conclusion: Our results suggest that MRP4 rs1751034 CC is associated with increased risk of IVIG resistance in KD.
Investigations of Kidney Dysfunction-Related Gene Variants in Sickle Cell Disease Patients in Cameroon (Sub-Saharan Africa)
Authors: Ngo-Bitoungui Valentina J. , Belinga Suzanne , Mnika Khuthala , Masekoameng Tshepiso , Nembaware Victoria , Essomba René G. , Ngo-Sack Francoise , Awandare Gordon , Mazandu Gaston K. , Wonkam Ambroise 
Published: March 2021

BackgroundRenal dysfunctions are associated with increased morbidity and mortality in sickle cell disease (SCD). Early detection and subsequent management of SCD patients at risk for renal failure and dysfunctions are essential, however, predictors that can identify patients at risk of developing renal dysfunction are not fully understood.MethodsIn this study, we have investigated the association of 31 known kidney dysfunctions-related variants detected in African Americans from multi-ethnic genome wide studies (GWAS) meta-analysis, to kidney-dysfunctions in a group of 413 Cameroonian patients with SCD. Systems level bioinformatics analyses were performed, employing protein-protein interaction networks to further interrogate the putative associations.ResultsUp to 61% of these patients had micro-albuminuria, 2.4% proteinuria, 71% glomerular hyperfiltration, and 5.9% had renal failure. Six variants are significantly associated with the two quantifiable phenotypes of kidney dysfunction (eGFR and crude-albuminuria): A1CF-rs10994860 (P = 0.02020), SYPL2-rs12136063 (P = 0.04208), and APOL1 (G1)-rs73885319 (P = 0.04610) are associated with eGFR; and WNT7A-rs6795744 (P = 0.03730), TMEM60-rs6465825 (P = 0.02340), and APOL1 (G2)-rs71785313 (P = 0.03803) observed to be protective against micro-albuminuria. We identified a protein-protein interaction sub-network containing three of these gene variants: APOL1, SYPL2, and WNT7A, connected to the Nuclear factor NF-kappa-B p105 subunit (NFKB1), revealed to be essential and might indirectly influence extreme phenotypes. Interestingly, clinical variables, including body mass index (BMI), systolic blood pressure, vaso-occlusive crisis (VOC), and haemoglobin (Hb), explain better the kidney phenotypic variations in this SCD population.ConclusionThis study highlights a strong contribution of haematological indices (Hb level), anthropometric variables (BMI, blood pressure), and clinical events (i.e., vaso-occlusive crisis) to kidney dysfunctions in SCD, rather than known genetic factors. Only 6/31 characterised gene-variants are associated with kidney dysfunction phenotypes in SCD samples from Cameroon. The data reveal and emphasise the urgent need to extend GWAS studies in populations of African ancestries living in Africa, and particularly for kidney dysfunctions in SCD.
Group 3 Innate Lymphoid Cells Protect Steatohepatitis From High-Fat Diet Induced Toxicity
Authors: Hamaguchi Masahide , Okamura Takuro , Fukuda Takuya , Nishida Kensuke , Yoshimura Yuta , Hashimoto Yoshitaka , Ushigome Emi , Nakanishi Naoko , Majima Saori , Asano Mai , Yamazaki Masahiro , Takakuwa Hiroshi , Kita Masakazu , Fukui Michiaki 
Published: March 2021

Background and Aims: Emerging evidence has revealed that innate lymphoid cells (ILCs) play a key role in regulating metabolic disorders. Here, we investigated the role of group 3 ILCs (ILC3s) in the modulation of Non-alcoholic fatty liver disease (NAFLD).Methods: RORγ gfp/gfp (RORgt KI/KI) and Rag2−/− mice with the administration of A213, RORgt antagonist, fed with a high-fat-diet (HFD) for 12 weeks, were used. We performed flow cytometry, real time PCR, and lipidomics analysis of serum and liver, and used RAW264.7 cells and murine primary hepatocytes in vitro.Results: HFD increased ILC3s and M1 macrophages in the liver, and RORgt KI/KI mice deficient in ILC3 showed significant fatty liver, liver fibrosis and significantly increased palmitic acid levels in serum and liver. In addition, administration of A213 to Rag2−/− mice caused significant fatty liver, liver fibrosis, and a significant increase in serum and liver palmitate concentrations, as in RORgt KI/KI mice. Addition of palmitc acid stimulated IL-23 production in cell experiments using RAW264.7. IL-22 produced by ILC3s inhibited the palmitate-induced apoptosis of primary hepatocytes.Conclusions: HFD stimulates IL-23 production by M1 macrophages, thus promoting ILC3 proliferation, whereas IL-22 secreted by ILC3s contributes to the upregulation of hepatic lipid metabolism and has anti-apoptosis activity.
Current Evidence and Future Perspective of Accuracy of Artificial Intelligence Application for Early Gastric Cancer Diagnosis With Endoscopy: A Systematic and Meta-Analysis
Authors: Jiang Kailin , Jiang Xiaotao , Pan Jinglin , Wen Yi , Huang Yuanchen , Weng Senhui , Lan Shaoyang , Nie Kechao , Zheng Zhihua , Ji Shuling , Liu Peng , Li Peiwu , Liu Fengbin 
Published: March 2021

Background &amp; Aims: Gastric cancer is the common malignancies from cancer worldwide. Endoscopy is currently the most effective method to detect early gastric cancer (EGC). However, endoscopy is not infallible and EGC can be missed during endoscopy. Artificial intelligence (AI)-assisted endoscopic diagnosis is a recent hot spot of research. We aimed to quantify the diagnostic value of AI-assisted endoscopy in diagnosing EGC.Method: The PubMed, MEDLINE, Embase and the Cochrane Library Databases were searched for articles on AI-assisted endoscopy application in EGC diagnosis. The pooled sensitivity, specificity, and area under the curve (AUC) were calculated, and the endoscopists' diagnostic value was evaluated for comparison. The subgroup was set according to endoscopy modality, and number of training images. A funnel plot was delineated to estimate the publication bias.Result: 16 studies were included in this study. We indicated that the application of AI in endoscopic detection of EGC achieved an AUC of 0.96 (95% CI, 0.94–0.97), a sensitivity of 86% (95% CI, 77–92%), and a specificity of 93% (95% CI, 89–96%). In AI-assisted EGC depth diagnosis, the AUC was 0.82(95% CI, 0.78–0.85), and the pooled sensitivity and specificity was 0.72(95% CI, 0.58–0.82) and 0.79(95% CI, 0.56–0.92). The funnel plot showed no publication bias.Conclusion: The AI applications for EGC diagnosis seemed to be more accurate than the endoscopists. AI assisted EGC diagnosis was more accurate than experts. More prospective studies are needed to make AI-aided EGC diagnosis universal in clinical practice.