bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effectiveness of the Transaction Systems on the Dax Index
Authors: Trembiński Marek , Stawska Joanna 
Published: September 2021

The purpose of the article/hypothesis: The aim of this article is to examine the effectiveness of trading systems built on the basis of technical analysis tools in 2015–2020 on the DAX stock exchange index. Efficiency is understood as generating positive rates of return, taking into account the risk incurred by the investor, as well as achieving better results than passive strategies. Presenting empirical evidence implying the value of technical analysis is a difficult task not only because of a huge number of instruments used on a daily basis, but also due to their almost unlimited possibility to modify parameters and often subjective evaluation.
Methodology: The effectiveness of technical analysis tools was tested using selected investment strategies based on oscillators and indicators following the trend. All transactions were carried out on the Meta Trader 4 platform. The analyzed strategies were comprehensively assessed using the portfolio management quality measures, such as the Sharpe measure or the MAR ratio (Managed Account Ratio).
Results of the research: The test results confirmed that the application of described investment strategies contributes to the achievement of effective results and, above all, protects the portfolio against a significant loss in the period of strong turmoil on the stock exchange. During the research period, only two strategies (Ichimoku and ETF- Exchange traded fund) would produce negative returns at the worst possible end of the investment. At the best moment, however, the „passive” investment achieved the lowest result. Looking at the final balance at the end of 2019, as many as four systems based on technical analysis were more effective than the „buy and hold” strategy, and at the end of the first quarter of 2020 – all of them. When analyzing the management quality measures, it turned out that taking into account the 21 quarters, the passive strategy had the lowest MAR index. The Sharpe’s measure is also relatively weak compared to the four leading strategies.
Health Capital and its Relationship to Economic Growth
Authors: Zarzycki Daniel , Malaczewski Maciej 
Published: September 2021

The purpose of the article/hypothesis: The purpose of this paper is to attempt to justify the thesis that the health potential of human and society has an impact on economic well-being, contributing to the economic growth of countries, and thus their enrichment.
Methodology: In order to examine the significance and strength of the impact of health capital on productivity on a macroeconomic scale, an econometric model of economic growth was used and six estimations were made in which the impact of subsequent components of this capital was examined.
Results of the research: It turned out that 4 out of 6 introduced variables of health capital significantly influenced economic growth, and their direction is consistent with the economic theory. This implies necessity for further studies.
The Impact of Financial Leverage on a Company’s Market Valuation
Authors: Zimny Artur 
Published: September 2021

The purpose of the article is to examine the impact of leverage on the market valuation of companies. The article verifies two hypotheses: 1. the degree of leverage is an important factor that impacts the market valuation of companies; 2. for companies with a high level of leverage, the impact of this leverage on their valuation is negative, and for companies with a low level of leverage, the impact is positive.
The methodology of the study includes a critical literature review and empirical research based on correlation and regression analysis, including univariate and multivariate regression. The analysis covered quarterly data of ten energy companies listed on the Warsaw Stock Exchange. An important component of the research was classifying those companies into several groups, depending on their level of debt ratio in relation to the industry median debt ratio.
The results of the research: The literature review did not provide an unequivocal conclusion to the problem. The empirical analysis did not give grounds to reject the first hypothesis; however, the second one was rejected. The research showed positive correlation and regression coefficients between the debt ratio and the price to book value ratio for highly leveraged companies and negative ones for companies with a low level of debt. The results are surprisingly contrary to the expectations based on theoretical premises.
Social impact assessment process for industry 4.0 to achieve sustainable artificial intelligence systems
Authors: Gurumurthy Iyer Vijayan 
Published: September 2021

The strategic environmental assessment (SEA) process can be broadly defined as a study of the social impacts of a proposed project, plan, policy or legislative action of intelligence systems on the society, environment and sustainability. The SEA process for sustainable intelligent systems has been aimed to incorporate society, environment and sustainability factors into the project planning and decision-making process for sustainable intelligent systems. Artificial intelligence systems (AIS) should consider the titled ‘environmental impact assessment (EIA)’ process that can be defined as the systematic identification and evaluation of the potential impacts (effects) of proposed projects, plans, programmes, policies or legislative actions relative to the biological physical, physico-chemical, biological, cultural, socio-economic and anthropological components of the total environment. The SEA process protocol is important as it has been proposed for studying and checking the productivity and quality of AIS. This treaty and official government procedures of SEA were helpful in the decision-making process much earlier than the EIA process.

Keywords: Artificial intelligence, business, economics, environment, industry.
A new strategy for curriculum learning using model distillation
Authors: Karakose Kaan , Bilgin Metin 
Published: September 2021

In recent years, deep neural networks have been successful in both industry and academia, especially for computer vision tasks. Humans and animals learn much better when gradually presented in a meaningful order showing more concepts and complex samples rather than randomly presenting the information. The use of such training strategies in the context of artificial neural networks is called curriculum learning. In this study, a strategy was developed for curriculum learning. Using the CIFAR-10 and CIFAR-100 training sets, the last few layers of the pre-trained on ImageNet Xception model were trained to keep the training set knowledge in the model’s weight. Finally, a much smaller model was trained with the sample sorting methods presented using these difficulty levels. The findings obtained in this study show that the accuracy value generated when trained by the method we provided with the accuracy value trained with randomly mixed data was more than 1% for each epoch.

Keywords: Curriculum learning, model distillation, deep learning, academia, neural networks.
Open-door servikal laminoplasti tekniğine bağlı hinge fraktürü (menteşe kırığı) komplikasyonu gelişmesini etkileyen risk faktörlerinin değerlendirilmesi
Authors: GÜRKAN Gökhan , KAYA İsmail , ATAR Murat , UZUNOGLU İnan , CİNGOZ İlker Deniz , SAYIN Murat , YÜCEER Nurullah 
Published: September 2021

Amaç: Open-door servikal laminoplasti multipl seviye servikal myelopatisi olan hastalar için standart
cerrahi seçenektir. Cerrahide laminanın bir tarafına lineer laminektomi yapılırken, karşı tarafa menteşe
halini alacak şekilde kemik drillemesi yapılır. Lineer laminektomi yapılan taraf kaldırılırken diğer tarafta
menteşe kırıkları meydana gelebilir. Bu kırıkların oluşmaması için olası risk faktörlerini incelemeyi
amaçladık.
Gereç ve Yöntemler: 2013-2018 yılları arasında open-door servikal laminoplasti operasyonu geçiren
olguların dosyaları, radyolojik görüntüleri, laboratuvar sonuçları retrospektif olarak incelendi.
Bulgular: Çalışmaya opere edilen 54 erkek, 24 kadın olmak üzere 78 hasta dahil edildi. Hastaların
yaş ortalaması 57,8 ± 11,6 idi. Operasyon öncesi hastaların Modifiye JOA (Japanese Orthopedic
Association) servikal miyelopati skorları 16,2 ± 2,1 olarak geldi. Operasyon öncesi kan Ca++
değerlerine bakıldığında 9,3 ± 0,5 mg/dl idi. Hastaların Pavlov oranı ortalaması 0,7 ± 0,2 idi. Laminalar
26 olguda sağ taraftan, 52 olguda sol taraftan açıldı. Toplam 304 lamina açıldı. Operasyon sonrası
çekilen kontrol servikal BT’lerde 42 hastada lamina menteşe kırığı vardı. Menteşe kırığı olmayan hasta
sayısı 36 idi. Toplamda 89 lamina seviyesinde kırık vardı. Cerrahi sonrası çekilen servikal BT’ler
incelendiğinde laminaların açılma açısı (OA) ortalaması 30,6 ± 8,9 derece olarak ölçüldü. Lamina
açılma açısının menteşe kırığına anlamlı ölçüde etki ettiği gözlendi. Lamina menteşe kırığı olan
hastalarda OA 32,3 ± 9 (p
Medium-term Effects of Enhanced External Counterpulsation in the Structural and Functional Parameters of Blood Vessels in Patients with Coronary Artery Disease
Authors: Karaganov K. S. , Slepova O. A. , Lishuta A. S. , Solomakhina N. I. , Belenkov Yu. N. 
Published: September 2021

Aim. To study the mid-term effects of enhanced external counterpulsation (EECP) in the structural and functional parameters of blood vessels, exercise tolerance and quality of life indicators in patients with verified coronary artery disease (CAD).Material and methods. Patients (n=70) with verified stable CAD (angina pectoris class II-III) complicated by chronic heart faillure class II-III (NYHA) were included in the study. Data from 65 patients (48 to 74 years old; 45 men and 20 women) are included in the final analysis. All patients had a course of EECP (35 hours procedures with a compression pressure of 220-280 mm Hg). All patients at baseline, 3 and 6 months later had a 6 walk minute test (6WMT), an assessment of the clinical status, quality of life of patients (Minnesota Living with Heart Failure Questionnaire, SF-36). Computer nailfold video capillaroscopy, photoplethysmography with pulse wave recording and contour analysis, applanation tonometry to assess central aortic systolic pressure and radial augmentation index were performed to assess the structural and functional state of large and microcirculatory vessels.Results. Significant improvement in exercise tolerance both after 3 and after 6 months (increase in distance in 6WMT by 44.6% after 3 months and 34.3% after 6 months, p <0.05), improved quality of life (increased overall score on the SF-36 questionnaire from 50.3±8.1 to 59.8±8.8, p<0.05), an increase in the left ventricular ejection fraction were found. Significant improvement in indicators showing the function of the endothelium of both large vessels (phase shift: from 5.6 [2.45; 7.3] to 6.8 [3.1; 8.1] m / s) and microcirculatory vessels (occlusion index: from 1.51 [1.21; 1.7] to 1.66 [1.2; 1.9]), as well as a decrease in functional disorders of the capillary bed of the skin (% of perfused capillaries, density of the capillary network in the test with reactive hyperemia) were found after 3 months. However, after 6 months, there were no significant changes in these parameters compared to the baseline value. No significant change in indicators showing structural remodeling of both large vessels and microcirculatory vessels was found.Conclusion. The positive effect of the EECP course on the functional status (exercise tolerance) and quality of life in patients with stable coronary artery disease complicated by chronic heart faillure was found both after 3 and 6 months. Positive dynamics of the functional state of large vessels and microvasculature was found only after 3 months.
E-cigarette Smoking (Vaping) and Markers of Vascular Wall Damage in Young Subjects without Cardiovascular Disease
Authors: Podzolkov V. I. , Bragina A. E. , Druzhinina N. A. , Mohammadi L. N. 
Published: September 2021

Aim: to investigate the effect of nicotine-containing vapes in comparison with traditional tobacco smoking on markers of vascular wall damage: high sensitivity C-reactive protein (hsCRP), albuminuria (AU), and ankle-brachial index (ABI).Material and Methods: We examined 369 young subjects without cardiovascular diseases (age median 21 [20;21] years) (159 men and 210 women). The hsCRP levels in the serum were assessed by immunochromatographic express method. AU was investigated in daily urine by a quantitative reflex photometry. ABI was determined by plethysmography.Results: All subjects were divided into groups: non-smokers (n=196, 53.1%), smokers of traditional cigarettes (n=83, 22.5%) and smokers of nicotine-containing vapes (n=90, 24.4%). The groups did not differ in main anthropometric data. Median hsCRP levels in smokers (14.30 [11; 16.5] mg/l in tobacco-smokers and 13.15 [9.65; 17.5] mg/l in vapers) were significantly higher vs nonsmokers (3.0 [2; 5.6] mg/l). In tobacco-smokers (33.0 [21.5; 60] mg) and vape smokers (45.0 [20; 115] mg), the median AU was statistically significantly higher than in non-smokers (12.0 [10; 20] mg). ABI levels were significantly lower in the groups of tobacco smokers (0.98 [0.91; 0.99]) and vapers (0.85 [0.79; 0.93]) when compared with nonsmokers (1.125 [1.01; 1.18]), and the median ABI in vapers was lower than in tobacco smokers (p<0.001). In the group of tobacco smokers, the hsCRP level correlated with the smoker's index (rs=0.31, p<0.05), and AU (rs=0.54, p<0.05) and ABI (rs=-0.28, p<0.05) with a daily inhaled nicotine dose. In the group of vapers, CRP was associated with smoking experience (rs=0.338, p<0.05), AU with a daily inhaled nicotine dose (rs=0.79, p<0.05), and ABI with BMI (rs=-0.33, p<0.05), heart rate (rs=-0.24, p<0.05) and smoking experience (rs=-0.235, p<0.05). According to the results of multivariate regression analysis the hsCRP level was related with only the smoking experience (B=0.91±0.19, p=0.000005), AU level with the daily inhaled nicotine dose (B=1.59±0.7, p=0.0121) and smoking experience (B=3.07±1.23, p=0.0179), and ABI level with only smoking experience (B=-0.09±0.004, p=0.0419).Conclusion: In smokers, both traditional and vapers, the levels of hsCRP, AU are significantly higher, and the ABI is lower than in healthy young nonsmokers. The most significant influence on the level of hsCRP is exerted by the experience of tobacco and vape smoking; to the AU level – the experience of tobacco and vaping and the daily inhaled nicotine dose, and by the value of the ABI – the experience of vaping.
Changes in anticoagulant prescription in a general hospital in 2008-2018
Authors: Kleymenova E. B. , Otdelenov V. A. , Nigmatkulova M. D. , Payushchik S. A. , Chernov A. A. , Konova O. D. , Yashina L. P. , Cherkashov A. M. , Sychev D. A. 
Published: September 2021

Aim. To study the structure of anticoagulant prescription in a general hospital to identify trends and contributing factors.Materials and methods. The study was conducted in an urban general hospital. According to retrospective retrieval from electronic health records, total 17,129 patients received anticoagulants from 2008 to 2018. Formal appropriateness of oral anticoagulants (OАС) prescriptions for 6,638 patients with atrial fibrillation (AF) was analyzed with CHA2-DS2-VASc score.Results. Appearance of recommendations for the direct oral anticoagulants (DOAC) prescription in clinical guidelines for venous thromboembolism (VTE) and AF management contributed to steady increase in the DOAC taking and decrease in the proportion of warfarin prescription. From 2011 to 2018, the proportion of patients with DOACs prescription increased from 1.7% to 81.5%. The most common indications for anticoagulant were ischemic stroke prevention in AF and VTE with mean rate 75.3% and 23.2%, respectively for the 2011-2018 period. Steady increase in low-molecular-weight heparin (LMWH) prophylactic prescriptions was also shown (Chi-square for linear trend=1340, df=1, p<0.0001). Since 2014, the prescription of LMWH in prophylactic doses increased dramatically, probably related to implementation of computerized decision support system (CDSS) for VTE prevention in the hospital.Conclusion. The study showed that in a general hospital anticoagulants were prescribed in 19% of hospitalized patient. Not only the new clinical recommendations based on the results of the recent studies on anticoagulants efficacy and safety (external factors), but also implementation standard operating protocols and CDSS, providing physicians current information about the relevant clinical recommendations (internal changes), could influence the appropriateness of anticoagulants prescription.
Epidemiological Observational Study on the Assessment of the Comorbidity and the Efficacy of the Treatment of Hypertensive Patients with Single Pill Combination of Lysinopril, Amlodipine and Rosuvastatin "PHENOTYPE-AG"
Authors: Savenkov M. P. , Ivanov S. N. , Borschevskaya M. V. , Okuneva I. N. , Ivanova S. V. , Savenkova A. M. , Dushkin R. V. 
Published: September 2021

Aim. To study the prevalence of comorbidity affecting the choice of antihypertensive treatment, as well as the efficacy and safety of the application of a single pill combination of lysinopril, amlodipine and rosuvastatin (SPC LAR) in hypertensive patients.Material and methods. Observational epidemiological study with the participation of 626 doctors and 13037 hypertensive patients with high cardiovascular risk and dyslipidemia treated with SPC LAR were held in 24 cities of Russia from November 2020 to March 2021. Prevalence and types of comorbidity, changes of blood pressure (BP), of total cholesterol (TC) and blood glucose levels and adverse events were studied during observation. Patients had 3 visits – initially, after 4 and 12 weeks. The obtained data was recorded by doctors through a web portal.Results. Concominant cardiovascular diseases found in all patients (in 38.7% of cases – from 2 to 5 diseases). The most commonly diseases were coronary artery disease (43.1%), metabolic syndrome (36.6%), diabetes (25.2%), chronic heart failure (24.9%), cerebrovascular diseases (12.3%) and chronic obstructive pulmonary disease (0.5%). SPC LAR with minimal doses of components (in 41.1% of patients) or with reinforced antihypertensive or hypocholesterolemic effects, based on the experience of treatment, the patient was prescribed as starting treatment with doctors. Reducing the level of systolic and diastolic BP, as well as the level Tc, respectively, by 20.9%, 16.9% and 29.7% found during the study. Target levels of systolic BP were achieved in 97.6% of patients, diastolic BP – in 99.6%, and target levels TC ≤5 mmol/l, ≤4 mmol/l and ≤3 mmol/l were achieved, respectively, in 94.5%, 68.6% and 23.5% patients. No significant dynamics of the level of glycemia were not found. The treatment was well tolerated by patients. Side effects found in 0.53% of patients (more often there was a dry cough, feet edema and headache). Commitment to treatment was 92.7%.Conclusion. The modern hypertension phenotype has cardiovascular atherosclerosis-associated diseases, which justifies the need to combine antihypertensive and hypolipidemic therapy. Triple SPC LAR, which effectively controlled the blood pressure and improved the violation of lipid metabolism was prescribed to patients in this observational study. The low frequency of side effects and good tolerance of treatment was accompanied by a high adherence of patients to treatment.
Monitoring of Aspirin Therapy in Patients with Cerebrovascular Pathology
Authors: Tanashyan M. M. , Raskurazhev A. A. , Kornilova A. A. , Shabalina A. A. , Abaimov D. A. , Naminov A. V. 
Published: September 2021

Aim. Evaluation of various methods for determining the effectiveness of aspirin therapy and aspirin resistance in patients with cerebrovascular disease (CVD) depending on the presence of type 2 diabetes mellitus (T2DM).Materials and methods. The prospective study included 78 patients with various manifestations of CVD. All patients received acetylsalicylic acid (ASA) 75 mg daily. Along with a comprehensive clinical examination, a laboratory assessment of platelet function with the usage of Born method with aggregometer, a detailed biochemical blood test (including the determination of the small subunit of low density lipoprotein [s-LDL]), as well as therapeutic drug monitoring of salicylates were performed on a gas chromatograph-mass spectrometer.Results. In 53% of cases, the absence or insufficiency of the effect of ASA on platelet aggregation was noted. Two subgroups were separately identified: with T2DM; (n=40) and without T2DM (n=38). Insufficient effect of the drug on platelet aggregation characteristics were observed in 65% of patients with T2DM and in 38% without T2DM. The differences were revealed between the groups in triglycerides, s-LDL, glycemic and glycated hemoglobin (p <0.05). In the group of patients with T2DM, the median ASA concentration was 0.01 [0; 0.32] μg/ml, and salicylic acid (SA)– 0.20 [0; 0.39] μg/ml, while in patients without T2DM higher values were noted: ASA 0.29 [0.15; 0.55] μg/ml, SA – 0.33 [0.05; 0.73] μg/ml. A decrease in the concentration of ASA was associated with an increase in the level of ADP-induced platelet aggregation. There was an increase in the levels of ADPand adrenaline-induced platelet aggregation with a decrease in the concentration of ASA (p=0.004) and SA (p=0.006). Therapeutic drug monitoring revealed a more significant decrease in ASA level in T2DM than in the comparison group (p=0.025).Conclusion. It is advisable to monitor aspirin therapy both with the assessment of platelet aggregation and with therapeutic drug monitoring. The relationship between the level of ASA and SA in the blood plasma and the functional activity of platelets was confirmed. The presence of T2DM is associated with a decrease in the concentration of ASA and aspirin resistance detected in therapeutic drug monitoring.
MATHEMATICAL MODELLING OF ONE-GROUP GAS-HYDRAULIC CIRCUIT OF THERMAL POWER PLANT STEAM BOILER AUXILIARIES
Authors: Vanin Viktor , Kruhol Mykola , Lasurenko Oleksandr 
Published: September 2021

The paper presents algebraic mathematical models of centrifugal mechanisms that operate in the power boiler gas-hydraulic circuit. The models have been built by means of head-flow curve approximation. The head-flow curve depends on the centrifugal mechanism blade rotating speed and guide vane angle. The least squares method has been applied for centrifugal mechanism head-curve approximation on the basis of experimental or numerical data. Different configurations for the connections of centrifugal mechanisms in the power boiler gas-hydraulic circuit have been considered, relationships for their performance assessment obtained, and efficiency factors for various methods of their capacity control introduced. The state equation for a complex gas-hydraulic network in the problem of its efficiency analysis has been obtained with application of Kirchhoff laws. Numerical algorithms have been developed to solve group control parameter optimization problems for the considered connections of centrifugal mechanisms. Features of mathematical models for groups of series-, parallel- and complex-connected centrifugal mechanisms with different head curves in the power boiler maintenance system have been specified. An optimal group control problem for a group of centrifugal mechanisms has been formulated and solved under various power boiler modes. For the feed pumps, individual frequency control proves to be the most effective method, while for the boiler draft mechanisms group frequency regulation turns out to be the most efficient. In a typical summer month, implementation of energy-efficient centrifugal mechanism capacity regulation method in a Thermal Power Plant is shown to result in auxiliary electricity consumption reduction by 10.96 % as compared with available actual data.