bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reinforcement learning control of robot manipulator
Authors: Cotrim Lucas Pereira , José Marcos Menon , Cabral Eduardo Lobo Lustosa 
Published: December 2021

Since the establishment of robotics in industrial applications, industrial robot programming involves therepetitive and time-consuming process of manually specifying a fixed trajectory, which results in machineidle time in terms of production and the necessity of completely reprogramming the robot for different tasks.The increasing number of robotics applications in unstructured environments requires not only intelligent butalso reactive controllers, due to the unpredictability of the environment and safety measures respectively. This paper presents a comparative analysis of two classes of Reinforcement Learning algorithms, value iteration (Q-Learning/DQN) and policy iteration (REINFORCE), applied to the discretized task of positioning a robotic manipulator in an obstacle-filled simulated environment, with no previous knowledge of the obstacles’ positions or of the robot arm dynamics. The agent’s performance and algorithm convergence are analyzed under different reward functions and on four increasingly complex test projects: 1-Degree of Freedom (DOF) robot, 2-DOF robot, Kuka KR16 Industrial robot, Kuka KR16 Industrial robot with random setpoint/obstacle placement. The DQN algorithm presented significantly better performance and reduced training time across all test projects and the third reward function generated better agents for both algorithms.
Cidades inteligentes assistivas apoiando nos cuidados das pessoas com deficiência: um mapeamento sistemático
Authors: Azevedo Neto Eduardo Gonçalves de , Tavares João Elison da Rosa , Barbosa Jorge Luis Victória 
Published: December 2021

Com o avanço das tecnologias móveis e melhorias nos dispositivos sem fio tornou-se possível solucionar problemas no âmbito social das cidades e proporcionar uma gama de alternativas para melhorar e implementar cada vez mais ambientes inteligentes, facilitando a vida cotidiana. Isso também se aplica às cidades inteligentes assistivas, que tem como objetivo proporcionar maior acessibilidade às pessoas com deficiência (PCDs), com necessidades especiais ou idosos, por meio de recursos computacionais que possibilitam diminuir ou sanar uma necessidade encontrada proporcionando mais conforto, acessibilidade e oportunidades. Este artigo apresenta um mapeamento sistemático que relaciona artigos que visam ampliar a acessibilidade e melhorar a qualidade de vida das pessoas com deficiência em cidades inteligentes assistivas. Esta pesquisa baseou-se em seis fontes de dados gerando um total de 93.998 artigos. Destes, após cinco etapas de filtragem e classificação resultaram em 21 artigos selecionados de acordo com o propósito desta pesquisa. Constatou-se que 47,6% destes trabalhos visam a segurança via monitoramento para facilitar a locomoção e acessibilidade diária dos PCDs. Verificou-se que 9,5% dos artigos abordam a comunicação e 28,6% visam tanto a comunicação do usuário quanto sua segurança. O entretenimento foi o tema central de 14,3% dos artigos selecionados.
Caracterización de las organizaciones colombianas en la era de las nuevas tecnologías y sus controles. Un análisis documental
Authors: López Carvajal Óscar 
Published: December 2021

La investigación pretende conocer el avance de las nuevas tecnologías en las organizaciones tanto públicas como privadas en Colombia, suscorrespondientes controles y conocer la realidad en el mundo iberoamericano a partir de un análisis documental, para lo cual se formuló la siguiente pregunta de investigación: ¿Cuál es la caracterización de las organizaciones colombianas en la era de las nuevas tecnologías y sus controles? Tal pregunta define los siguientes objetivos: Principal: Analizar la caracterización de las organizaciones colombianas en la era de las nuevas tecnologías y sus controles; Específicos: 1. Entender el posicionamiento de Colombia frente a otros países en relación con las tendencias de la era digital; 2. Interpretar las nuevas tendencias, tecnologías y estrategias surgidas en la era digital en Iberoamérica.
Pengaruh E-Wom, Lifestyle, Kepercayaan Terhadap Keputusan Pembelian Ticket Online Booking Pada Situs Traveloka.Com Di Ponorogo (Studi Kasus Pembelian Tiket Pesawat Dan Kereta Api)
Authors: Sari Vivi Endah 
Published: December 2021

This research is made in order to identify the effect of Electronic Word Of Mouth, Lifestyle, and Trust towards online ticket Buying Decision on Traveloka.com site. Traveloka.com is one of the most famous online ticket buying site in Indonesia. The subject of this research refers to Ponorogo citizens whom have done online ticket buying on Traveloka.com site. The research use analysis double linear regression, the research took in total 97 samples with probability sampling method. Result of this research shown that Electronic Word Of Mouth, Lifestyle, and Trust has positive and significant influence towards Buying Decision both simultaneously and partially. Meanwhile, the determination coefficient shown 66,1% value for the contribution of Electronic Word Of Mouth, Lifestyle, and Trust and the rest is 33,9% value which is affected by other variable not explained in this research.
Preliminary Evaluation of Standing Full-Length Plain Radiographs Utility in an Adult Degenerative Spine Practice
Authors: Parrish James M. , Jenkins Nathaniel W. , Haws Brittany E. , Cha Elliot D. K. , Lynch Conor P. , Patel Madhav R. , Jacob Kevin C. , Jadczak Caroline N. , Mohan Shruthi , Geoghegan Cara E. , Louie Philip K. , Hirsch Brandon P. , Colman Matthew W. , Singh Kern 
Published: December 2021

Introduction:
The role of weight-bearing full-length standing radiographs (FLSRs) of the spine in the preoperative workup of adult degenerative disease of the lumbar spine is a subject of increasing research. This investigation aims to determine whether FLSR influences preoperative planning decisions.

Methods:
In this prospective study, eight spine surgeons reviewed two 30-patient case series. The first set (set A) contained a patient history, physical examination data, and preoperative images. The second set (set B) contained all information in set A in addition to preoperative FLSR AP and lateral radiographs. Within 2 weeks of evaluating set A, reviewers assessed set B. Case sets were randomized. After reviewing each set, reviewers gave surgical plans and whether they believed an FLSR was important in planning. Decisions were evaluated by subspecialty, years of practice, and postfellowship years. A McNemar test assessed differences between set viewings. A chi-square test assessed differences of preoperative decision changes between different specialties and levels of experience. A Poisson regression assessed characteristics associated with changing preoperative plans. We analyzed patients by the number of unique reviewer procedures, surgical levels, and associated pathology.

Results:
After viewing an FLSR, 44.7% of reviewers changed procedure. Reviewer opinion of FLSR importance differed between sets (27.1% versus 35.7%, P = 0.047). Among all reviewers, FLSR presentation was associated with aligning the number of proposed procedures in 15 patients. Scoliosis and sacral dysplasia were associated with negative deltas. FLSR viewing reduced the span of operational levels considered. Along the most divided patients, those with a high magnitude (≥6 choices) of initial procedures had more negative deltas than did those with a high number (≥5 choices) of surgical level choices.

Conclusion
FLSR remains a critical aspect of presurgical planning. Even when reviewers initially believed patients would not benefit from FLSR, we observed changes in preoperative planning after FLSR viewing.
HUBUNGAN DERAJAT KEPARAHAN STROKE DENGAN PERUBAHAN STATUS GIZI PASIEN DI UNIT STROKE
Authors: Camelia Bomaztika Sari  , Hertanto Wahyu Subagio  , Etisa Adi Murbawani  
Published: December 2021

Latar belakang : Defisit neurologis akibat stroke akut menyebabkan perburukan malnutrisi selama perawatan di rumah sakit dan dikaitkan dengan outcome klinis lebih buruk, masa rawat lebih lama dan biaya lebih besar.
Tujuan: Menganalisis hubungan derajat keparahan stroke dengan perubahan status gizi pasien selama pelayanan di Unit Stroke dan faktor-faktor yang mempengaruhinya.
Metode : Penelitian cross-sectional dilakukan di Unit Stroke RSUP dr. Kariadi Semarang pada bulan Maret - Mei 2019 terhadap 60 subyek pasien stroke yang dipilih secara consecutive sampling serta memenuhi kriteria inklusi dan eksklusi. Penilaian NIHSS dilakukan pada awal dan akhir pengamatan; pengukuran dan perubahan LLA pada hari ke-1, ke-3, ke-7, ke-14; status diare serta status disfagia. Uji Chi-square dilakukan untuk melihat hubungan antara derajat keparahan stroke dengan faktor-faktor yang berhubungan dengan perubahan status gizi pasien.
Hasil: Derajat keparahan stroke sedang dan berat lebih banyak dijumpai. Target pemenuhan energi hari ke-5 dapat dicapai 80% subyek, penurunan LLA 35%, diare 11,7% dan disfagia 46,7%. Terdapat hubungan signifikan antara derajat keparahan stroke dengan perubahan LLA (p < 0,05).
Simpulan : Derajat keparahan stroke berhubungan dengan perubahan status gizi selama perawatan yang dinilai dari penurunan LLA.
HUBUNGAN KONTROL GLIKEMIK PREOPERATIF DAN GANGGUAN GINJAL AKUT PASCA CORONARY ARTERIAL BYPASS GRAFTING PADA PASIEN DIABETES MELLITUS
Authors: Rayhan Muhammad , Joe Juweni 
Published: December 2021

Latar Belakang: Diabetes mellitus (DM) dan kontrol glikemik telah diajukan sebagai salah satu faktor risiko gangguan ginjal akut (GGA) pasca coronary arterial bypass grafting (CABG) walaupun dengan bukti yang terbatas, sehingga hubungan kedua penyakit perlu diteliti lebih lanjutTujuan: Tujuan penelitian ini adalah memberikan bukti lebih lanjut terkait pengaruh DM dan kontrol glikemik terhadap insidensi GGA pasca CABG.
Metodologi: Suatu penelitian dengan desain cross sectional dilaksanakan di unit perawatan intensif bedah dewasa National Cardiovascular Center Harapan Kita, Jakarta, Indonesia. Populasi penelitian ini mencakup 84 subjek dengan metode sampling konsekutif. Kontrol glikemik pasien DM diklasifikasikan berdasarkan target nilai HbA1c pada panduan American Diabetes Association 2018. Analisis secara bivariat dilakukan untuk melihat hubungan antara berbagai faktor dan insidensi GGA. Berbagai faktor disesuaikan dengan analisis multivariat untuk menilai peran DM dan kontrol glikemik sebagai faktor independen.
Hasil: Rerata usia dan tekanan darah sistolik berbeda secara signifikan antar kelompok dengan rerata usia tertinggi pada kelompok DM terkontrol dan tekanan darah tertinggi pada kelompok DM tidak terkontrol. Karakteristik demografis dan berbagai faktor selain DM tidak menunjukan hubungan yang signifikan dengan insidensi GGA. Analisis multivariat menunjukan bahwa pada kelompok DM dengan HbA1c terkontrol, insidensi GGA lebih rendah secara signifikan (OR 0.13, IK 95%, 0.13 - 0.24) dibandingkan dengan kelompok lainnya. Rasio odd GGA lebih tinggi pada kelompok DM tidak terkontrol, tetapi tidak terbukti signifikan secara statistik (OR 1.03, IK 95%, 0.158 - 6.69).
Simpulan: Penelitian ini memberikan bukti pentingnya kontrol glikemik pra-operasi dalam mencegah terjadinya GGA pasca CABG pada pasien diabetes.
EFFECT OF MATERNAL VITAMIN D SUPPLEMENTATION DURING LACTATION EFFECT ON INFANTS' PROPENSITY TO INFECTION : AN EVIDENCE-BASED CASE REPORT
Authors: Kosasih Raphael , Sunardi Diana 
Published: December 2021

Abstract
Introduction: Vitamin D deficiency has become more prevalent around the world along with a sedentary lifestyle and limited exposure to sunlight. Deficiencies of vitamin D in lactating mothers could cause deficiencies in their infants and vitamin D deficient infants are at higher risk of having infectious diseases. Supplementation of Vitamin D to lactating mothers may benefit both mothers and infants to reduce infection morbidity.
Methods: Relevant literature research was conducted in PubMed, Cochrane, and SciELO using relevant keywords and advanced search methods. Relevant literature was then screened for duplication, relevance, and eligibility.
Results: A randomized-controlled trial was selected. The study showed that supplementation of 3000µg oral vitamin D3 to lactating mothers significantly raise their infants' serum vitamin D (p<0.01) and reduce infection morbidity (p<0.01)
Conclusions: Oral supplementation of vitamin D3 could be given to lactating mothers to improve their infants' serum vitamin D and reduce infection morbidity.
Keywords: vitamin D, lactation, infants' infection
Summary on the application of the gravitational method to eliminate intercasing pressure
Authors: Yershiev K. T. , Akhmetov D. А. , Aitkulov Y. K. , Koldey M. , Naukenov A. Zh. , Takinbayev M. Zh. , Kusherbayev R. B. , Tyulegenov I. A. , Bek A. Е. , Islamberdiyev Zh. A. 
Published: December 2021

This article provides an analysis and summary of the experience of using the gravity method for eliminating annular pressure in the wells of the subsidiaries and dependent companies of JSC NC KazMunayGas.
The analysis used the actual data obtained immediately after the elimination of annular pressure in wells using a compositional composition on a hydrocarbon basis by gravity replacement of annular fluid.
Biodiversité végétale précoce de cinq affluents de la Sélune dans la vallée renaturée de Vezin (Normandie)
Authors: RAVOT Charlotte , LE CŒUR Didier , DUFOUR Simon , BERNEZ Ivan 
Published: December 2021

La restauration de la continuité écologique du fleuve Sélune se traduit par un aménagement actif correspondant à l’arasement de deux grands barrages hydroélectriques (hauteurs de 36 m et 16 m) sans précédent en Europe. Le programme scientifique comprend une analyse de la recolonisation spontanée de l’ancien lac de Vezin (une longueur de 19 km pour une superficie de 160 ha). Des baisses de niveaux successives ont dénoyé progressivement les plages de sédiments de la néo-vallée (2015-2018). Un creusement du lit mineur, un stockage des sédiments par reprofilage localisé des berges (travaux de génie civil) ont permis la prévention du risque érosif (emportement potentiel de 700 000 m3 de sédiments mobilisables). Ces vases exondées, que l’on veut bloquer dans la néo-vallée, constituent des milieux pionniers ouverts à la recolonisation végétale. Les deux années de suivi (2017-2018) visent à observer le patron spatial et la trajectoire des communautés végétales spontanées des points de vue structurel, écologique et taxonomique. Les communautés végétales spontanées des néo-rives du cours principal de la Sélune dans l’ancien lac de barrage (19 km × 2 berges, Ordre de Strahler [OD] de 5) sont différentes de celles des cinq principaux ruisseaux affluents de la néo-vallée (de quelques centaines de mètres chacun au sein de la nouvelle vallée, OD de 1 à 3). Ces petits ruisseaux contribuent au recrutement d’une flore riparienne spontanée différent de celui des 38 km de rives du cours principal de la Sélune. Ces résultats de génie écologique renforcent la possibilité d’une restauration écologique passive des berges de la néo-vallée, avec l’assurance de l’obtention d’une mosaïque d’habitats ripariens.
The Mediterranean Spearfish in Ancient Greek and Latin
Authors: Tadajczyk Konrad , Witczak Krzysztof 
Published: December 2021

The article discusses the problem of identifying a Mediterranean fish called γλαῦκος in Ancient Greek and glaucus in Latin. It was a big and well-known fish living in the Mediterranean Sea. It appears in numerous literary sources of the classical (Greek and Roman) world. After analyzing all preserved attestations of the Greco-Latin ichthyonym, the authors of the present article suggest that this fish should be identified with the Mediterranean spearfish (Tetrapturus belone Rafinesque, 1810). It is possible that the fish name γλαῦκος/glaucus referred to the roundscale spearfish (Tetrapturus georgii R.T. Lowe, 1841) and also to the Atlantic white marlin (Kajikia albida Poey, 1860, syn. Tetrapturus albidus Poey, 1860).
Overexpression of SKA3 correlates with poor prognosis in female early breast cancer
Authors: Zhong Yue , Zhuang Zhenjie , Mo Peiju , Lin Mandi , Gong Jiaqian , Huang Jiarong , Mo Haiyan , Lu Yuyun , Huang Mei 
Published: December 2021

Background
Spindle and kinetochore associated complex subunit 3 (SKA3) plays an important role in tumorigenesis and the progression of various tumors. But the relationship between SKA3 and early breast cancer remains unclear. The study aimed to explore the prognostic significance of SKA3 in breast cancer.

Methods
In the study, SKA3 expression was initially assessed using the Oncomine database and The Cancer Genome Atlas database (TCGA). Then, we presented validation results for RT-qPCR (quantitative reverse transcription PCR) and ELISA (enzyme-linked immunosorbent assay). The relationship between clinical characteristics and SKA3 expression was assessed by Chi-square test and Fisher’s exact test. Kaplan–Meier method and Cox regression analysis were conducted to evaluate the prognostic value of SKA3. Gene set enrichment analysis (GSEA) was performed to screen biological pathways using the TCGA dataset. Besides, single sample gene set enrichment analysis (ssGSEA) was utilized to identify immune infiltration cells about SKA3.

Results
SKA3 mRNA was expressed at high levels in breast cancer tissues compared with normal tissues. Chi-square test and Fisher’s exact test showed SKA3 expression was related to age, tumor (T) classification, node (N) classification, tumor-node-metastasis (TNM) stage, estrogen receptor (ER), progesterone receptor (PR), molecular subtype, and race. RT-qPCR results showed that SKA3 expression was overexpressed in ER, PR status, and molecular subtype in Chinese people. Kaplan–Meier curves implicated that high SKA3 expression was related to a poor prognosis in female early breast cancer patients. Cox regression models showed that high SKA3 expression could be used as an independent risk factor for female early breast cancer. Four signaling pathways were enriched in the high SKA3 expression group, including mTORC1 signaling pathway, MYC targets v1, mitotic spindle, estrogen response early. Besides, the SKA3 expression level was associate with infiltrating levels of activated CD4 T cells and eosinophils in breast cancer.

Conclusion
High SKA3 expression correlates with poor prognosis and immune infiltrates in breast cancer. SKA3 may become a biomarker for the prognosis of breast cancer.
3D Series Metal Complexes Containing Schiff Base Ligand with 2,2'-Bipyridine: Synthesis, Characterization and Assessment of Antifungal Activity
Authors: Kpomah B. , Ugbune U. , Idu T. E. 
Published: December 2021

The rapid increase in the number of multidrug-resistant of most pathogenic organisms is fast becoming a global concern, thus, the discovery of novel active pharmacological compounds against new targets is a matter of urgency. The incorporation of metal ions into organic ligands has introduced metal-organic drugs framework with synergistic effects for novel applications in the biological system. In this research work, metal(II) chloride complexes of copper, nickel and zinc containing methylphenylketone thiosemicarbazone (MPK-TSC) with 2,2’-bipyridine (bipy) were synthesized; they were further characterized by satisfactory microelemental analysis, Fourier Transform InfraRed (FTIR) spectra as well as electronic spectra study. The complexes are proposed to have the formulae [L1ML2(Cl2)] where M=metal ion, L1=methylphenylketone thiosemicarbazone L2=2,2’-bipyridine. The complexes are of 1:2 (metal:ligand) stoichiometry and non-electrolytes in solution, the bidentate nature of the two ligands was evident from the FTIR spectra. The compounds were screened for their antifungal activity against four pathogenic fungi: Aspergillus niger, Penicillium Species, Rizopus and Candida albicans using disc diffusion method. The activities of the complexes have been found to be greater than those of the metal salts and the uncoordinated ligands.
Determination of Anti-Pseudomonal Activities of Cocoa (Theobroma cacao) Pod Husk using Time-Kill-Test and Agar-Well Diffusion Techniques
Authors: Azeez I. A. , Deji- Agboola A.M. , Owolabi S. L. , Boyejo A. O. , Issah A. O. , Buhari O. A. , Ikeola M. F. 
Published: December 2021

Aim: To determine the antimicrobial effectiveness of cocoa pod husk against P. aeruginosa.
Study Design: An experimental research
Place and Duration of Study: Department of Medical Microbiology, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria, between June 2015 and Sept. 2016.
Materials and Methods: Seventy-seven (77) isolates of P. aeruginosa obtained from three (3) teaching hospitals were involved in this study. Cocoa pod husk was processed into crude extract and its effectiveness against the isolates of P. aeruginosa were examined using agar well diffusion, time-kill test techniques and Anova.
Results: The percentage susceptibility of P. aeruginosa to Cocoa pod husk at 500 mg/mL and 250 mg/mL inhibited all the P. aeruginosa but only 14.29% were sensitive at a lower concentration of 31.25 mg/mL. Moreover, the comparison between the broth micro and macro dilution method of determining the MIC of cocoa pod husk against P. aeruginosa highlighted a significant decrease in the mean MIC value of the broth micro dilution method when compared with the broth macro dilution technique (T=13.519, P<0.05). The time kill test emphasized that P. aeruginosa was killed at a lower concentration of 62.5mg/ml at 150mins of introduction in to the Cocoa pod husk suspension.
Conclusion: This study revealed that the Cocoa pod husk possesses antibacterial properties. An increase in the concentration of cocoa pod husk increased its antibacterial activity against Pseudomonas aeruginosa. Moreover, the broth micro dilution technique is sensitive for determining the anti-pseudomonal activity.
Determination of Terpenoid Profile in Dry Cannabis Flowers and Extracts Obtained from Different Cannabis Varietes
Authors: Serafimovska Tijana , Serafimovska Marija Darkovska , Mitevska Marija , Stefanovski Sasho , Keskovski Zlatko , Stefkov Gjoshe , Balkanov Trajan , Ribarska Jasmina Tonic 
Published: December 2021

Aim: The aim of this study was to determine the terpenoid profile in dried cannabis flowers obtained from different varieties of cannabis plant and in cannabis extracts in order to investigate quantity of terpenes lost during extraction and purification process.
Methods: GC/MS method for determination of terpenes was verified. The concentration of terpenes was determined in dry flowers as raw material and in decarboxylated and distillated cannabis extracts, using the same GC/MS analytical method. The extraction was performed using 96% ethanol as a solvent.
Results: The obtained results indicate that dry cannabis flowers from different cannabis plant can be distinguished only by their terpenoid profile. The use of standardized cannabis-based extracts can be confirmed by determination of terpenoid profile. The purification process of the cannabis extracts removes terpenes. The percentage of major terpen beta-Myrcene decreased from 68% in dry flower to 15% in decarboxylated and, 1.9% in distillated cannabis oil after purification. The percentage of second major terpene alpha-Pinene decreased from 15% in dry flower to 5% in decarboxylated and, 0.7% in distillated cannabis oil after purification.
Conclusion: Terpenes act synergistically with cannabinoids. Following the monograph for quality testing of cannabis extracts in the German Pharmacopoeia, the purification process is necessary to achieve a final concentration of cannabinoids (Tetrahydrocannabinol) of more than 95% in the final active pharmaceutical ingredient. The purification process removes terpenes that have proven synergistically pharmacological effects with cannabinoids.