bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular complications with a plug‐based vascular closure device after transcatheter aortic valve replacement: Predictors and bail‐outs
Authors: van Wiechen Maarten P. , Kroon Herbert , Hokken Thijmen W. , Ooms Joris F. , de Ronde‐Tillmans Marjo J. , Daemen Joost , de Jaegere Peter P. , Van Mieghem Nicolas M. 
Published: February 2021

AbstractBackgroundThe MANTA vascular closure device (VCD) is dedicated to large bore access closure and associated with favorable results in selected study populations. Anatomical predictors for access site complications are lacking.AimTo evaluate MANTA in a real‐world population and identify predictors for vascular complications.MethodsAll patients undergoing transfemoral transcatheter aortic valve replacement (TAVR) between January 2016 and May 2020 with MANTA closure were included. Baseline characteristics were collected, pre‐procedural computed tomography and post‐deployment femoral angiograms were analyzed for anatomical differences. The primary endpoint was a composite of access site related major and minor vascular complications at 30 days follow‐up according to the VARC‐2 definitions. Secondary endpoints included bleeding, time to hemostasis, procedural length and incomplete arteriotomy closure or arterial occlusion by angiography. A Cox proportional hazards model was used to compare all‐cause mortality for patients with and without an access site complication.ResultsThe 512 patients underwent TAVR with MANTA access closure. Median age was 80 (IQR 75–85), 53% was male, median BMI was 26.4 kg/m2 (IQR 23.4–29.7). Access site related major‐ or minor vascular complication occurred in 20 (4%) and 23 (4%) of patients respectively. Median time to hemostasis was 42 s (IQR 28–98). Post deployment angiogram showed an occlusion in 24 patients (5%), incomplete closure in 60 patients (12%) or both in three patients (1%). Of these 87 patients, 36 (41%) had a vascular complication. Femoral artery diameter (OR 0.70 [0.53–0.93]), low‐ (OR 3.47 [1.21–10.00]) and high (OR 2.43 [1.16–5.10]) arteriotomies were independent predictors for vascular complications.ConclusionIn this contemporary TAVR population, access‐site related complications occurred in 8% of patients and were mainly due to percutaneous closure device failure. Small artery diameter and off‐target punctures were independent predictors.
Subcutaneous C1‐Inhibitor Concentrate for prophylaxis during pregnancy and lactation in a patient with C1‐INH‐HAE
Authors: Andarawewa Shimalee , Aygören‐Pürsün Emel 
Published: February 2021

AbstractSubcutaneous plasma‐derived human C1‐Inhibitor concentrate (pdC1INH) may be safe and effective for long‐term prophylaxis during pregnancy and lactation in hereditary angioedema patients.
Acquired thrombotic thrombocytopenic Purpura diagnosed during first trimester of pregnancy with excellent outcome after plasma exchange and rituximab, a case report
Authors: Arzuaga‐Mendez Javier , Moreno Maite , Mateos‐Mazón Juan J. , Vara Miriam , Dueñas Marta , Del Orbe Rafael A. , Amutio Elena , Arrizabalaga Beatriz , García‐Ruiz Juan C. 
Published: February 2021

Key Clinical MessageAcquired thrombotic thrombocytopenic purpura is a life‐threatening condition that rarely presents during pregnancy. Early diagnosis and treatment with plasma exchange is needed to achieve a good pregnancy outcome.
Prenatal detection of a giant isolated coronary fistula
Authors: Walter Adeline , Calite Elina , Engels Alexander C. , Herberg Ulrike , Breuer Johannes , Willruth Arne , Berg Christoph , Geipel Annegret , Gembruch Ulrich 
Published: February 2021

AbstractPrenatal detection of an isolated congenital coronary artery fistula (ICCAF) requires an examination of the affected fetal hemodynamic situation by the fistula. Early pediatric cardiological presentation is needed, since prenatal changes may have relevant postpartal consequences.
Clinical cases of amyotrophic lateral sclerosis concurrent with hydromyelia
Authors: Bogdanov Enver I. , Mendelevich Elena G. , Khabibrakhmanov Aydar N. , Bogdanov Shamil E. , Mukhamedzhanova Gyulnara R. , Mukhamedyarov Marat M. 
Published: February 2021

AbstractA comprehensive work‐up, clinical correlation, and differential diagnosis are needed to determine if abnormal findings such us hydromyelia in ALS patients are causative or incidental in order to rule out other, more curable conditions that resemble ALS.
Primary biliary cholangitis‐autoimmune hepatitis overlap syndrome: Case report and literature review
Authors: Razafindrazoto Chantelli Iamblaudiot , Rakotozafindrabe Andry Lalaina Rinà , Randriamifidy Nitah Harivony , Rasolonjatovo Anjaramalala Sitraka , Rabenjanahary Tovo Harimanana , Razafimahefa Soloniaina Helio , Ramanampamonjy Rado Manitrala 
Published: February 2021

AbstractParis criteria remain practical for retaining the diagnosis of overlap syndrome. While liver histology is mandatory, its absence should not be an obstacle to the diagnosis and delay the initiation of treatment in countries where biopsy not available.
Disseminated cryptococcosis in a deceased with HIV‐1 diagnosed by minimally invasive tissue sampling technique
Authors: Subedi Nuwadatta , Bhattarai Suraj , Ranabhat Sunita , Sharma Binita K. , Baral Madan P. , Upadhyaya Tirtha L. 
Published: February 2021

AbstractMinimal invasive tissue sampling (MITS) technique detected HIV infection and disseminated cryptococcosis in an adult female with sudden death. A proper autopsy is essential to diagnose the exact cause of death and MITS can suffice in natural deaths.
Chronic vertebrobasilar insufficiency in subclavian steal syndrome
Authors: Phillips Stephanie , Memon Anza B. 
Published: February 2021

AbstractSubclavian steal syndrome is a vascular disorder that consists of significant blood supply restriction with resultant insufficiency of the vertebrobasilar artery and the subclavian artery causing symptomatic insufficiency to the brain and upper extremity. It is important to recognize this condition in patients with subacute to chronic posterior circulation vascular insufficiency as early diagnosis and treatment can have good clinical outcomes (J Clin Neurosci. 2010;17:1339). CT angiogram of the head and neck should be considered in patients with chronic vertebrobasilar insufficiency to evaluate subclavian steal syndrome.
Biphasic Titania Derivatives of Titanium Metal‐Organic Framework Nanoplates for High‐Efficiency Photoreduction of Diluted CO2 to Methane
Authors: Zheng Ya‐Li , Ren Jia‐Tong , Zhou Liang , Yuan Kun , Sun Xiao‐Chen , Yin Hai‐Jing , Zhang Ya‐Wen 
Published: February 2021

AbstractExploring earth‐abundant materials for low concentration CO2 photoreduction is the key in the energy related field. Here, we demonstrated biphasic titania (anatase and rutile) derived from Ti‐based metal‐organic framework (MOF) nanoplates exhibited excellent performance in CO2 photoreduction without any co‐catalysts and sacrificial agents under ambient condition, the maximum CH4 production rate was up to 65.39 μmol g−1 h−1 with near 100 % electron selectivity as well as great stability. The activity of the optimal derivative was maintained well even in 1 % CO2 (CH4: 45.59 μmol g−1 h−1) and much better than that of commercial P25. The upgraded performance originated from the synergism between local anatase/rutile interface and numerous defective sites (Ti3+ and Ov), by promoting the separation and migration of photogenerated carriers, CO2 adsorption and activation, and H2O dissociation. Besides, a possible fast hydrodeoxygenation mechanism for methane formation was proposed according to in situ DRIFTS characterization.
Harnessing the Synergistic Interplay of Fischer‐Tropsch Synthesis (Fe‐Co) Bimetallic Oxides in Na‐FeMnCo/HZSM‐5 Composite Catalyst for Syngas Conversion to Aromatic Hydrocarbons
Authors: Nawaz Muhammad Asif , Li Minzhe , Saif Maria , Song Guiyao , Wang Zihao , Liu Dianhua 
Published: February 2021

AbstractThe efficient conversion of syngas to aromatic hydrocarbons (STA) has attracted attention in recent years for its extensive utilization in the energy and defense sectors. In current study, the alloying of two active FT synthesis metal components (Fe−Co) was employed in Na‐FeMnCo/HZSM‐5 composite catalyst for STA process. Different calcination temperatures and Fe/Mn/Co molar ratios were modulated for harnessing the different Fe2O3/CoFe2O4/MnCo2O4 structures that possessed divergent structural, reduction, carburization and catalytic behaviors to give Fe3O4/FexC/CoxC reactive species. Herein, the effective inclusion of Co and Mn into Fe brought about the expedient geometric and electronic modulations for providing the homogenously distributed CoFe2O4 nanocrystals. This particular substitution of Fe played a vital role for tuning the density of oxygen vacancies, tailoring the reduction behavior of Fe‐Ox, giving the Fe−Co alloy structure, and adjusting the adsorption capabilities of catalytic surface that mainly dictate the concentration of active Fe5C2 phase. An escalated selectivity to olefinic intermediates and subsequent higher aromatics fractions (∼55 %) thus was imparted with an inhibited CO2 (21 %) generation by meliorating the different Fischer‐Tropsch/Aromatization reactions in stable CO conversion of ∼98 %.
Polymorphs of the Gadolinite‐Type Borates ZrB2O5 and HfB2O5 Under Extreme Pressure
Authors: Pakhomova Anna , Fuchs Birgit , Dubrovinsky Leonid S. , Dubrovinskaia Natalia , Huppertz Hubert 
Published: February 2021

AbstractBased on the results from previous high‐pressure experiments on the gadolinite‐type mineral datolite, CaBSiO4(OH), the behavior of the isostructural borates β‐HfB2O5 and β‐ZrB2O5 have been studied by synchrotron‐based in situ high‐pressure single‐crystal X‐ray diffraction experiments. On compression to 120 GPa, both borate layer‐structures are preserved. Additionally, at ≈114 GPa, the formation of a second phase can be observed in both compounds. The new high‐pressure modification γ‐ZrB2O5 features a rearrangement of the corner‐sharing BO4 tetrahedra, while still maintaining the four‐ and eight‐membered rings. The new phase γ‐HfB2O5 contains ten‐membered rings including the rare structural motif of edge‐sharing BO4 tetrahedra with exceptionally short B−O and B⋅⋅⋅B distances. For both structures, unusually high coordination numbers are found for the transition metal cations, with ninefold coordinated Hf4+, and tenfold coordinated Zr4+, respectively. These findings remarkably show the potential of cold compression as a low‐energy pathway to discover metastable structures that exhibit new coordinations and structural motifs.
Overview of N‐Rich Antennae Investigated in Lanthanide‐Based Temperature Sensing
Authors: Vanden Bussche Flore , Kaczmarek Anna M. , Van Speybroeck Veronique , Van Der Voort Pascal , Stevens Christian V. 
Published: February 2021

AbstractThe market share of noncontact temperature sensors is expending due to fast technological and medical evolutions. In the wide variety of noncontact sensors, lanthanide‐based temperature sensors stand out. They benefit from high photostability, relatively long decay times and high quantum yields. To circumvent their low molar light absorption, the incorporation of a light‐harvesting antenna is required. This Review provides an overview of the nitrogen‐rich antennae in lanthanide‐based temperature sensors, emitting in the visible light spectrum, and discusses their temperature sensor ability. The N‐rich ligands are incorporated in many different platforms. The investigation of different antennae is required to develop temperature sensors with diverse optical properties and to create a diverse offer for the multiple application fields. Molecular probes, consisting of small molecules, are first discussed. Furthermore, the thermometer properties of ratiometric temperature sensors, based on di‐ and polynuclear complexes, metal–organic frameworks, periodic mesoporous organosilicas and porous organic polymers, are summarized. The antenna mainly determines the application potential of the ratiometric thermometer. It can be observed that molecular probes are operational in the broad physiological range, metal–organic frameworks are generally very useful in the cryogenic region, periodic mesoporous organosilica show temperature dependency in the physiological range, and porous organic polymers are operative in the cryogenic‐to‐medium temperature range.
The Supramolecular Structural Chemistry of Pentafluorosulfanyl and Tetrafluorosulfanylene Compounds
Authors: Liebing Phil , Pitts Cody Ross , Reimann Marc , Trapp Nils , Rombach David , Bornemann Dustin , Kaupp Martin , Togni Antonio 
Published: February 2021

AbstractThe analysis of crystal structures of SF5‐ or SF4‐containing molecules revealed that these groups are often surrounded by hydrogen or other fluorine atoms. Even though fluorine prefers F⋅⋅⋅H over F⋅⋅⋅F contacts, the latter appeared to be important in many compounds. In a significant number of datasets, the closest F⋅⋅⋅F contacts are below 95 % of the van der Waals distance of two F atoms. Moreover, a number of repeating structural motifs formed by contacts between SF5 groups was identified, including different supramolecular dimers and infinite chains. Among SF4‐containing molecules, the study focused on SF4Cl compounds, including the first solid‐state structure analyses of these reactive species. Additionally, electrostatic potential surfaces of a series of Ph‐SF5 derivatives were calculated, pointing out the substituent influence on the ability of F⋅⋅⋅X contact formation (X=F or other electronegative atom). Interaction energies were calculated for different dimeric arrangements of Ph‐SF5, which were extracted from experimental crystal structure determinations.
Clinical and pathological differences between skin‐limited IgM/IgG vasculitis and skin‐limited IgA vasculitis
Authors: Kawamura Miho , Mizutani Yuki , Mizutani Yoko , Matsuyama Kanako , Shu En , Miyazaki Tatsuhiko , Seishima Mariko 
Published: February 2021

AbstractObjectivesCutaneous IgM/IgG vasculitis (IgM/IgG V) is characterized by leukocytoclastic vasculitis histologically and by IgM‐ or IgG‐ perivascular deposition. However, clinical differences between IgM/IgG V and skin‐limited IgA vasculitis (IgA V) have not been fully clarified. In the present study, we assessed the clinical and histopathological differences between IgM/IgG V and IgA V.MethodsWe examined 14 patients with IgM/IgG V and 24 patients with skin‐limited IgA V. The cases associated with systemic diseases were excluded. Clinical findings, laboratory data, and histological findings were compared between IgM/IgG V and IgA V groups.ResultsLivedo lesions appeared more often, and palpable purpura less often in IgM/IgG V. Localization of the lesions was more limited to the lower legs in IgM/IgG V. In laboratory data, there were no statistical differences in peripheral blood cell counts, IgG, IgA, and IgM levels between the two groups. Histopathological findings showed less infiltration of neutrophils, CD8+ T cells, and CD3+ T cells, and nuclear dusts in IgM/IgG V. Systemic steroids were administered significantly less frequently in IgM/IgG V cases, but the recurrence rate did not differ.ConclusionsBased on these results, IgM/IgG V may be a clinically and histologically different entity from IgA V. However, further studies are necessary to define the differences between them more clearly.
Numerical investigation of liquid‐liquid two‐phase separation and pressure drop characteristics in T‐junctions
Authors: Zhi Changshuang , Liu Liu , Chen Pengfan , Liu Yingwen 
Published: February 2021

AbstractBased on the Eulerian and k − ε viscous models, a numerical model of liquid‐liquid two‐phase flow in a T‐junction was established. The simulation results were in reasonable agreement with the experimental data. The effects of the mass fraction taken off through branch and mixture velocity on the separation efficiency and pressure drop characteristics were investigated using the validated model. The results illustrate that the separation efficiency first increases and then decreases with an increase in the mass fraction taken off through branch. When the mass fraction taken off through branch is close to the inlet mass quality, the separation efficiency reaches its maximum. The maximum separation efficiency decreases with the increase of the mixture velocity. In addition, the pressure drop from the inlet to the outlet is primarily due to the local resistance at the intersection and frictional resistance in the pipe, and the pressure drop from the inlet to the branch is majorly caused by the gravity in the branch. It was observed that there is a vortex region at the inlet of the outlet pipe, causing pressure losses.
Teaching process design in a multidisciplinary capstone design course
Authors: Couturier Michel F. , Bendrich Guida 
Published: February 2021

AbstractTo increase the percentage of our graduates trained in a multidisciplinary setting, we have pooled resources from several departmental capstone design courses to create a common multidisciplinary course with a novel structure. The new course consists of multiple sections, one for each of the project types previously offered in the departmental courses. The new teaching platform has increased the choice of capstone design projects available to students and provides the flexibility to form multidisciplinary as well as mono‐disciplinary teams of students depending on the needs of the projects. In the process design section of the course, teams of four or five students work on design projects sponsored by industry and are co‐mentored by a practicing engineer and a faculty member. Seven evenly spaced milestones are used to pace students, guide mentors, and facilitate the progressive assembly of a high‐quality final report. Peer evaluations are also used to improve team dynamics and are combined with mentor ratings to derive individual grades from the assessment of team deliverables. The normalized peer ratings of effective team members follow a normal distribution with a mean of unity and a SD of 0.04, whereas the ratings of ineffective members fall below the distribution. Our collaborative approach for teaching process design provides a motivating educational experience to students and each of the course learning outcomes was achieved by over 95% of the students during the first two offerings of the course.
Particle image velocimetry (PIV) experimental investigation of flow structures and dynamics produced by a centripetal turbine
Authors: Jin Jie , Fan Ying 
Published: February 2021

AbstractTurbines are capable of producing powerful radial discharge flow, which is why they are widely applied in such fields as chemical, petroleum, pharmaceutical, and so on. The centripetal turbine (CT) represents a new type of optimized turbine structure based on the Rushton turbine (RT). In order to reveal the characteristics of turbulence, centripetal and Rushton turbines were designed. The flow fields of impellers were measured by two‐dimensional particle image velocimetry (PIV), in combination with the time‐averaged method, phase‐resolved method, and proper orthogonal decomposition (POD) method for comparative analysis. Within the measured area, the time‐averaged velocity and phase‐resolved velocity of the CT is smaller compared to the RT. The numeric range of fluctuation velocity for the two types of impeller is basically the same, but the high‐value area of CT is more widely distributed. The swirling strength of the CT is significantly smaller than that of the RT. Besides, the wake structure is significantly weakened, which is conducive to reducing power consumption. The POD triple decomposition method proves effective in decoupling the instantaneous flow field into mean part, coherent part, and turbulence part. In each phase of blade passage, the turbulence part energy of the CT is considerably higher. For different blade passages, the cyclic variation of the CT is more significant. The flow field generated by the CT exhibits stronger eddy diffusion, which is conducive to mixing or reaction. It provides a basis for understanding the turbulent flow characteristics of CTs and impeller optimization.
Gelatin – an efficient separator for electrochemical experiments in school
Authors: Lüke Dennis , Oetken Marco 
Published: February 2021

AbstractDurch das Gießen eines leitfähigen Gelatine‐Lyogels im Micro‐Scale‐Aufbau kann eine kostengünstige Zelle für elektrochemische Schulversuche hergestellt werden, die mit wenigen Millilitern Elektrolyt betrieben werden kann, Lernenden einen einfachen visuellen Zugang zur Phänomenebene der Halbzellreaktionen bietet, keine Bruchgefahr im Schüler*innen‐Experiment darstellt und zudem deutlich leistungsfähiger ist als ein vergleichbarer Aufbau im klassischen U‐Rohr.
Summit: Benchmarking Machine Learning Methods for Reaction Optimisation
Authors: Felton Kobi C. , Rittig Jan G. , Lapkin Alexei A. 
Published: February 2021

AbstractIn the fine chemicals industry, reaction screening and optimisation are essential to development of new products. However, this screening can be extremely time and labor intensive, especially when intuition is used. Machine learning offers a solution through iterative suggestions of new experiments based on past experimental data, but knowing which machine learning strategy to apply in a particular case is still difficult. Here, we develop chemically‐motivated virtual benchmarks for reaction optimisation and compare several strategies on these benchmarks. The benchmarks and strategies are encompassed in an open‐source framework named Summit. The results of our tests show that Bayesian optimisation strategies perform very well across the types of problems faced in chemical reaction optimisation, while many strategies commonly used in reaction optimisation fail to find optimal solutions.
Helical Nanofibers Formed by Palladium‐Mediated Assembly of Organic Homochiral Macrocycles Containing Binaphthyl and Pyridyl Units
Authors: Agnes Marco , Arabi Ameneh , Caricato Marco , Nitti Andrea , Dondi Daniele , Yannakopoulou Konstantina , Patrini Maddalena , Pasini Dario 
Published: February 2021

AbstractHerein, we report the synthesis and characterization of homochiral macrocycles, in which molecular rigidity, combined with the presence of multiple functional groups, allow for the assembly of helical nanostructures. 1,1’‐bi‐2‐naphthol (Binol) units are used as robust chirality inducers, and pyridyl units embedded within the molecular frameworks allow the assembly, upon coordination with Pd(II) metal ions, of the macrocyclic building blocks. CD and NMR spectroscopies show the formation of ordered 1D assembly in solution. AFM studies indicate that the molecular systems are capable of forming nanoscale structures. The effective transfer of chiral information results in helical nanofibers, with lengths ranging from a few hundreds of nanometers to some micrometers. AFM line profiles reveal a helical longitudinal period of about 50 nm and a transverse width of 25 to 45 nm after deconvolution.