bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the influence of lean manufacturing practices on employee social sustainability
Authors: Ciannella Stéfano , Santos Luciano Costa 
Published: November 2021

Purpose
The benefits of adopting lean manufacturing for leveraging corporate sustainability have been highlighted in the literature. However, these studies have neglected the social side of sustainability compared with the attention given to the environmental aspects. Addressing this gap, this paper aims to investigate the influence of lean practices on the dimensions of employee social sustainability (ESS), which enabled the identification of the most critical practices.

Design/methodology/approach
This paper conducted an exploratory study in two phases: first, seeking evidence in the literature, and second, applying the analytic hierarchy process (AHP) to connect ESS to lean practices based on expert opinion.

Findings
From the literature review, this paper found linkages between eight lean manufacturing practices and four dimensions of ESS. Based on evidence from the literature, the authors designed and applied an AHP model to set priorities among lean practices and social dimensions. Therefore, “health and safety” was evaluated as the most critical social dimension, and 5S was considered the most influential lean practice on ESS.

Originality/value
This study contributed to introducing the perspective of lean manufacturing practices as enablers of ESS. Notably, it pointed out which specific practices should be prioritized in the lean implementation process with social sustainability purposes. In addition, it identified relationships not reported in the literature, raising questions for further investigation.
Identification of patients at high risk of secondary extramedullary multiple myeloma development
Authors: Stork Martin , Sevcikova Sabina , Minarik Jiri , Krhovska Petra , Radocha Jakub , Pospisilova Lenka , Brozova Lucie , Jarkovsky Jiri , Spicka Ivan , Straub Jan , Pavlicek Petr , Jungova Alexandra , Jelinek Tomas , Sandecka Viera , Maisnar Vladimir , Hajek Roman , Pour Ludek 
Published: November 2021

SummaryMultiple myeloma (MM) is characterized by malignant plasma cell infiltration of the bone marrow. In extramedullary multiple myeloma (EMD), a subclone of these cells migrates out of the bone marrow. Out of 4 985 MM patients diagnosed between 2005 and 2017 in the Czech Republic, we analyzed 234 secondary EMD patients to clarify risk factors of secondary EMD development. We found younger age [<65 years; odds ratio (OR) 4·38, 95% confidence interval (CI): 2·46–7·80, P < 0·0001], high lactate dehydrogenase (LDH) levels (>5 μkat/l; OR 2·07, 95% CI: 1·51–2·84, P < 0·0001), extensive osteolytic activity (OR 2·21, 95% CI: 1·54–3·15, P < 0·001), and immunoglobulin A (IgA; OR 1·53, 95% CI: 1·11–2·11, P = 0·009) or the non‐secretory type of MM (OR 2·83; 95% CI: 1·32–6·04, P = 0·007) at the time of MM diagnosis to be the main risk factors for secondary EMD development. Newly diagnosed MM (NDMM) patients with subsequent EMD had inferior median progression‐free (PFS) and overall (OS) survival when compared to NDMM patients without future EMD [mPFS: 13·8 months (95% CI: 11·4–16·3) vs 18·8 months (95% CI: 17·7–19·9), P = 0·006; mOS: 26·7 months (95% CI: 18·1–35·4) vs 58·7 months (95% CI: 54·8–62·6), P < 0·001]. We found that NDMM patients with specific risk factors associated with secondary EMD development have a more aggressive disease course before secondary EMD develops.
Parenthood in the shadow of COVID‐19: The contribution of gender, personal resources and anxiety to first time parents' perceptions of the infant
Authors: Chasson Miriam , Ben‐Yaakov Ofir , Taubman – Ben‐Ari Orit 
Published: November 2021

AbstractWe sought to examine new parents' perceptions of their infant during the worldwide spread of COVID‐19, exploring the contribution of gender, personal resources (attachment orientation, presence of meaning in life and intolerance of uncertainty) and COVID‐19‐related anxieties. A convenience sample of 606 Israeli first‐time parents (137 fathers and 469 mothers), whose child was 3–12 months old, was recruited through social media during April 2020. Findings indicate that being a woman, younger age, lower education, better physical health, older infant's age, lower attachment anxiety, higher presence of meaning in life and greater COVID‐19‐related anxiety over the infant's health contributed significantly to a greater perception of infant's warmth; being a father, higher education and economic status, poorer physical health, higher attachment anxiety and intolerance of uncertainty and less presence of meaning in life contributed significantly to a greater perception of infant's invasiveness. Gender moderated the associations between the personal resources and infant's perception, and both the presence of meaning in life and intolerance of uncertainty mediated the associations between COVID‐19‐related anxieties and parent's perception of the infant. The findings reveal the crucial contribution of gender, and both risk and resilience factors, to the parent's perception of the infant in the shadow of COVID‐19.
Distant metastasis and prognostic factors in patients with invasive ductal carcinoma of the breast
Authors: Chen Xiaofei , Zhang Chenyang , Guo Dingjie , Wang Yashan , Hu Junjun , Hu Jiayi , Wang Song , Liu Xin 
Published: November 2021

AbstractObjectiveTo explore the risk factors and prognostic factors of invasive ductal carcinoma (IDC) and to predict the survival of IDC patients with metastasis.MethodWe used multivariate logistic regression to identify independent risk factors affecting metastasis in IDC patients and used Cox regression to identify independent prognostic factors affecting the overall survival of patients with metastasis. Nomogram was used to predict survival, while C‐index and calibration curves were used to measure the performance of nomogram. Kaplan‐Meier method was used to calculate the survival curves of patients with different independent prognostics factors and different metastatic sites, and the differences were compared by log‐rank test. The data of our study were obtained from the Surveillance, Epidemiology and End Results cancer registry.ResultOur study included 226,094 patients with IDC. In multivariate analysis, independent risk factors of metastasis included age, race, marital status, income, geographic region, grade, T stage, N stage, subtype, surgery and radiotherapy. Independent prognostic factors included age, race, marital status, income, geographic region, grade, T stage, N stage, subtype, surgery and chemotherapy. We established a nomogram, of which the C‐index was 0.701 (0.693, 0.709), with the calibration curves showing that the disease‐specific survival between actual observation and prediction had a good consistency. The survival curves of different metastatic patterns were significantly different (log‐rank test: χ2 = 18784, p < 0.001; χ2 = 47.1, p < 0.001; χ2 = 20, p < 0.001).ConclusionThe nomogram we established may provide risk assessment and survival prediction for IDC patients with metastasis, which can be used for clinical decision‐making and reference.
Early warning signs of population irruptions in Eastern Grey Kangaroo (Macropus giganteus)
Authors: Wilson Michelle , Coulson Graeme 
Published: November 2021

SummaryLeft unchecked, macropods (kangaroos and wallabies) can exhibit irruptive population dynamics, rising rapidly to a peak, then crashing when overwhelmed by inadequate resources. This predictable population trajectory frequently leads to overabundance issues, particularly in peri‐urban parks and nature reserves. Management decisions are usually guided by estimates of population density, which can be difficult to obtain, sometimes inaccurate and often inadequate because long‐term data are needed to estimate population growth. Alternatively, density‐dependent vital rates could be used to predict the growth trajectory of a population before management issues become evident. We applied a framework of sequential changes in vital rates to examine potential indicators of population growth trajectory. We sampled 16 populations of Eastern Grey Kangaroo (Macropus giganteus) in south‐eastern Australia. Using a range of methods, we measured one vital rate (female reproductive rate) and one surrogate rate (adult sex ratio). As population density increased before irruptive peaks, female reproductive rate (90% breeding) was higher than during post‐peak declines (66% breeding). Similarly, sex ratios in increasing populations were at parity and then became more female‐biased (65% females) after peaks. These variables are readily measured in small parks and reserves, and therefore offer promising indicators of population growth trajectory, which can be used to forecast management issues and initiate timely management actions.
Hyaluronan: A key player or just a bystander in skin photoaging?
Authors: Šínová Romana , Pavlík Vojtěch , Ondrej Martin , Velebný Vladimír , Nešporová Kristina 
Published: November 2021

AbstractPhotoaged skin exhibits signs of inflammation, DNA damage and changes in morphology that are visible at the macroscopic and microscopic levels. Photoaging also affects the extracellular matrix (ECM) including hyaluronan (HA), the main polysaccharide component thereof. HA is a structurally simple but biologically complex molecule that serves as a water‐retaining component and provides both a scaffold for a number of the proteins of the ECM and the ligand for cellular receptors. The study provides an overview of the literature concerning the changes in HA amount, size and metabolism, and the potential role of HA in photoaging. We also suggest novel HA contributions to photoaging based on our knowledge of the role of HA in other pathological processes, including the senescence and inflammation‐triggered ECM reorganization. Moreover, we discuss potential direct or indirect intervention to mitigate photoaging that targets the hyaluronan metabolism, as well as supplementation.
Insight into the fracture evolution behavior of pre‐flawed hollow‐cylinder granite under multi‐stage increasing‐amplitude cyclic loads: A lab‐scale testing
Authors: Wang Yu , Yang Haonan , Han Jianqiang , Zhu Chun 
Published: November 2021

AbstractThe structural deterioration and associated fracture evolution behavior of pre‐flawed hollow‐cylinder granite subjected to multi‐stage increasing‐amplitude (MSIA) cyclic loads are studied herein. The influences of rock structure on volumetric deformation, damage accumulation, energy dissipation, and failure pattern were investigated. It is shown that the volumetric deformation is relatively large for rock having high flaw angle, and it is the minimum and maximum for rock having a 10° and 70° flaw angle. A damage evolution model that can describe a first fast and then steady damage propagation was proposed based on the irreversible axial strain. Much energy needs to be consumed to drive crack propagation and hole collapse for rock having high angle flaws. A series of 2D computed tomography (CT) images reveal the different crack network pattern and how it is affected by the rock structure. A more complicated crack network is found for rock having a high flaw angle.
Mechanisms of soil organic carbon stability and its response to no‐till: A global synthesis and perspective
Authors: Kan Zheng‐Rong , Liu Wen‐Xuan , Liu Wen‐Sheng , Lal Rattan , Dang Yash Pal , Zhao Xin , Zhang Hai‐Lin 
Published: November 2021

AbstractMechanisms of soil organic carbon (SOC) stabilization have been widely studied due to their relevance in the global carbon cycle. No‐till (NT) has been frequently adopted to sequester SOC; however, limited information is available regarding whether sequestered SOC will be stabilized for long term. Thus, we reviewed the mechanisms affecting SOC stability in NT systems, including the priming effects (PE), molecular structure of SOC, aggregate protection, association with soil minerals, microbial properties, and environmental effects. Although a more steady‐state molecular structure of SOC is observed in NT compared with conventional tillage (CT), SOC stability may depend more on physical and chemical protection. On average, NT improves macro‐aggregation by 32.7%, and lowers SOC mineralization in macro‐aggregates compared with CT. Chemical protection is also important due to the direct adsorption of organic molecules and the enhancement of aggregation by soil minerals. Higher microbial activity in NT could also produce binding agents to promote aggregation and the formation of metal‐oxidant organic complexes. Thus, microbial residues could be stabilized in soils over the long term through their attachment to mineral surfaces and entrapment of aggregates under NT. On average, NT reduces SOC mineralization by 18.8% and PE intensities after fresh carbon inputs by 21.0% compared with CT (p < .05). Although higher temperature sensitivity (Q10) is observed in NT due to greater Q10 in macro‐aggregates, an increase of soil moisture regime in NT could potentially constrain the improvement of Q10. This review improves process‐based understanding of the physical and chemical mechanism of protection that can act, independently or interactively, to enhance SOC preservation. It is concluded that SOC sequestered in NT systems is likely to be stabilized over the long term.
Depth‐dependent drivers of soil microbial necromass carbon across Tibetan alpine grasslands
Authors: He Mei , Fang Kai , Chen Leiyi , Feng Xuehui , Qin Shuqi , Kou Dan , He Hongbo , Liang Chao , Yang Yuanhe 
Published: November 2021

AbstractMicrobial necromass carbon (C) has been considered an important contributor to persistent soil C pool. However, there still lacks large‐scale systematic observations on microbial necromass C in different soil layers, particularly for alpine ecosystems. Besides, it is still unclear whether the relative importance of biotic and abiotic variables such as plant C input and mineral properties in regulating microbial necromass C would change with soil depth. Based on the combination of large‐scale sampling along a ~2200 km transect across Tibetan alpine grasslands and biomarker analysis, together with a global data synthesis across grassland ecosystems, we observed a relatively low proportion of microbial‐derived C in Tibetan alpine grasslands compared to global grasslands (topsoil: 45.4% vs. 58.1%; subsoil: 41.7% vs. 53.7%). We also found that major determinants of microbial necromass C depended on soil depth. In topsoil, both plant C input and mineral protection exerted dominant effects on microbial necromass C. However, in subsoil, the physico‐chemical protection provided by soil clay particles, iron‐aluminum oxides, and exchangeable calcium dominantly facilitated the preservation of microbial necromass C. The differential drivers over microbial necromass C between soil depths should be considered in Earth system models for accurately forecasting soil C dynamics and its potential feedback to global warming.
Dominant outflow vein occlusion in the management of naturally occurring peripheral arteriovenous anomalies in cats and dogs
Authors: Hyndman Philip S. , Weisse Chick , Schwartz Pamela , Rosen Robert J. 
Published: November 2021

AbstractTwo dogs and 1 cat were referred to a tertiary veterinary center for the consultation and treatment of limb edema, variable dermal sanguineous crusting lesions, and intermittent lameness. A peripheral arteriovenous anomaly (PAA) was diagnosed via computed tomographic angiography (CTA) in each case. Arteriography enabled further evaluation of the PAA with confirmation of a dominant outflow vein. Dominant outflow vein occlusion was achieved by direct ligation in 1 dog and retrograde transvenous glue embolization in the cat and other dog. Repeat arteriography demonstrated resolution of arteriovenous shunting. Presenting clinical signs resolved in all animals. The previously identified aberrant vessels in 1 dog were not identified after CTA 40 days postoperatively. No postoperative complications or recurrence was identified in any case during the 6‐ to 55‐month follow‐up period.
Multilocus sequence typing of strains from the Cryptococcus gattii species complex from different continents
Authors: Bellet Virginie , Roger Frédéric , Krasteva Donika , Gouveia Tiphany , Drakulovski Pascal , Pottier Cyril , Bertout Sébastien 
Published: November 2021

AbstractBackgroundCryptococcus neoformans and Cryptococcus gattii species complexes are pathogens causing cryptococcal meningitis, a fungal infection that leads to death unless treated. Worldwide, it is estimated to kill over 180,000 individuals annually.ObjectivesWe aim to investigate the molecular diversity of C. gattii isolates from strains isolated from 1995 to the present day from different continents.MethodIn this study, we analysed the molecular diversity by MLST and antifungal susceptibility by using the broth microdilution method according to the CLSI M27‐A4 protocol of a total of 26 strains from Cryptococcus gattii species complex from both clinical and environmental sources.ResultsGenotyping showed that most of the strains (17/26; 65.4%) belonged to serotype B and were distributed between three genotypes: VGI (13/17; 76.5%), VGII (3/17; 17.6%) and VGVI (1/17; 5.9%). The serotype C strains (9/26; 34.6%) were distributed between the VGIII (1/9; 11.1%) and VGIV (8/9; 88.9%) genotypes. The 26 strains belonged to 17 different MLST subtypes, and we highlight four new MLST genotypes (ST553, 554, 555 and 556). The two environmental strains were identified as serotype B and genotype VGI, but were of ST 51 and 154. All isolates have wild‐type MIC of fluconazole and flucytosine. Regarding amphotericin B, five VGI strains showed MICs to AMB equal to 1 µg/ml, and according to the ECV for these genotypes, they were considered non‐wild‐type strains.ConclusionsThe current study reveals the genetic diversity and new sequence types among strains from the C. gattii complex species.
Non‐surgical management of oro‐antral communication using platelet‐rich fibrin: A review of the literature
Authors: Sabri Hamoun , Sarkarat Farzin , Mortezagholi Bardia , Aghajani Dorsa 
Published: November 2021

AbstractOro‐antral communication (OAC) is an opening between the maxillary sinus and the oral cavity, which can provide a pathway to cause an infection of the maxillary sinus. Although surgical techniques propose many advantages, several drawbacks have been reported in the previous studies. Bioactive modifiers such as platelet‐rich fibrin (PRF) are widely being used in oral surgery. Various studies have been conducted for closure of OACs using PRF. Due to the heterogeneity of the techniques found, we opted for a literature review to highlight the variety of techniques discussed in the literature. A comprehensive search of the PubMed, Google Scholar and Cochrane databases was performed for published articles between 2014 and 2021. Keywords for OAC management and repair and inclusion criteria were used to screen articles for final review. Out of 195 articles found, 12 articles were included to the study. Eight studies performed simple direct application of PRF clots, 2 studies used PRF in combination with collagen membrane and in 2 studies the treatment plan was to use buccal advancement flap reinforced by PRF. There were several variations among approaches to the closure of OAC using PRF in terms of treatment planning, pre‐ and post‐operative medication and preparation of PRF. Despite the mentioned variations, review of recent studies showed that all of the cases experienced full epithelialisation of OAC. This technique, without manipulation of any additional flaps and auto‐grafts, has several advantages. However, further research, both experimental and clinical, is necessary to unravel the success rate of using PRF in the management of OACs.
Ichthyosiform changes in a patient with RAC1 mutation
Authors: Haugh Isabel Mary , Pineider Juliana L , Agim Nnenna Gebechi 
Published: November 2021

AbstractRAS‐related C3 Botulinum Toxin Substrate 1 (RAC1) is a Rho GTPase that modulates numerous cellular functions including transcriptional regulation and actin‐based structure turnover. Reported de novo RAC1 mutations are rare but generally manifest in developmental delay and brain malformations. In Rac1 knockout mice, a hairless phenotype has been observed, but little is known of other cutaneous phenotypes of RAC1 mutations. In this report, we describe the first known case of a RAC1 mutation with ichthyosiform changes.
Expanding the palette of pediatric playthings: A call to action for pediatric dermatologists
Authors: Lee Michelle S. , Linggonegoro Danny W. , Huang Jennifer T. , Nambudiri Vinod E. 
Published: November 2021

AbstractChildren recognize race and skin color from a young age. Given the important role of play in the development of children's understanding of social norms and cultural values, it is essential to incorporate toys and other educational materials with diverse skin tones to teach children about race and skin color. Analyses of children's books and toys have shown a lack of diversity in representation of races and skin types. Pediatric dermatologists are uniquely positioned to foster conversations about skin tone and advocating for more diverse materials in classrooms and clinics. In this manuscript, we discuss best practices and resources for facilitating discussions on skin tone with children in the dermatology clinic.
Examining the Influence of Impairment Type on the Development of Paralympic Sport Athletes
Authors: Dehghansai Nima , Allan Veronica , Pinder Ross A. , Baker Joe 
Published: November 2021

Research has recently examined the role of impairment onset on athlete development in Paralympic sport; however, less is known on how impairment type can impact athlete sporting pathways. In this study, 187 Australian and Canadian Paralympic sport athletes completed a survey. Participants were divided into the following four groups: impaired muscle power (n = 79); ataxia, athetosis, and hypertonia (n = 44); limb deficiencies (n = 42); and other physical impairments (n = 22). Mechanisms of initiation into Paralympic sport varied between groups with some drawn to sport through friends and/or family (i.e., limb deficiencies and other physical impairments groups) while others through talent search programs (i.e., ataxia, athetosis, and hypertonia group) or health care professionals/rehabilitation centers (i.e., impaired muscle power group). Results revealed no significant differences between groups in the chronological age or absolute years for achieving milestones. However, considering the high variability within the sample, more research is necessary to better understand how athletes with different physical impairments navigate through their sporting careers.