bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of convective characteristics during tropical cyclogenesis
Authors: Kilroy Gerard 
Published: February 2021

AbstractFour idealized, high‐resolution (500 m horizontal grid spacing), numerical simulations are used to investigate the evolution of convective structures during tropical cyclogenesis. The simulations all begin with a weak initial axisymmetric cloud‐free vortex in a quiescent environment, but differ in the moisture level of the initial sounding and whether or not ice microphysical processes are considered. Irrespective of experimental setup, there is only a short period where shallow or congestus clouds dominate. The shallow cloud phase is slightly extended with the drier initial environmental sounding. The composite structure of the convective elements sampled changes markedly throughout the genesis period. For much of the genesis phase, vertical profiles of the mean convective cell show significant amounts of anticyclonic vorticity produced in cells in the inner core. Towards the end of the genesis phase, there is a large increase in the production of cyclonic vertical vorticity in inner‐core convection, and cyclonic vorticity becomes dominant at low‐mid levels. The evolution from roughly equal strength vertical profiles of cyclonic/anticyclonic vorticity at low‐mid levels to profiles where cyclonic vorticity dominates occurs at relatively low system wind speeds (Vmax less than 10 m·s−1). This finding indicates a change in the structure of vortical convection prior to rapid intensification. In outer‐core convection, there are roughly equal strength vertical vorticity dipoles produced throughout the genesis period.
Wood screw design: influence of thread parameters on the withdrawal capacity
Authors: Hoelz Kevin , Kleinhans Lukas , Matthiesen Sven 
Published: February 2021

AbstractSelf-tapping wood screws are important fasteners in timber construction. A characteristic of these screws is their high axial load-bearing capacity, which also depends on their withdrawal capacity. This is used for structural design and is thus an important optimization parameter for wood screws. To increase the withdrawal capacity, knowledge of the influence of the thread parameters, such as outer diameter, pitch or flank angle, is required. The influences of pitch and flank angle on the withdrawal capacity have not yet been sufficiently subjected to research and are therefore investigated in this study. A total of ten specially developed screw prototypes with pitches in the range of 3.04 mm and 5.9 mm and flank angles in the range of 35° and 45° are used. The screw prototypes are flat ribbed bars with uncoiled screw thread. The effect on the withdrawal capacity is measured using an experimental setup based on test standard EN 1382:2016. The pitch showed a significant influence (p = 0.000, f = 0.37) whereas the influence of flank angle was not significant (p = 0.283). A smaller pitch leads to a higher withdrawal capacity, irrespective of the flank angle. The experimental results are explained based on the theoretical models of bonding mechanisms and conical stress distribution. To optimize the withdrawal capacity of a ø 8 mm screw, a smaller pitch is preferable. The determined influence of the pitch can also be used to improve the accuracies of calculation models for the withdrawal capacity.
Social media in surgery: evolving role in research communication and beyond
Authors: Grossman Rebecca , Sgarbura Olivia , Hallet Julie , Søreide Kjetil 
Published: February 2021

AbstractPurposeTo present social media (SoMe) platforms for surgeons, how these are used, with what impact, and their roles for research communication.MethodsA narrative review based on a literature search regarding social media use, of studies and findings pertaining to surgical disciplines, and the authors’ own experience.ResultsSeveral social networking platforms for surgeons are presented to the reader. The more frequently used, i.e., Twitter, is presented with details of opportunities, specific fora for communication, presenting tips for effective use, and also some caveats to use. Details of how the surgical community evolved through the use of the hashtag #SoMe4Surgery are presented. The impact on gender diversity in surgery through important hashtags (from #ILookLikeASurgeon to #MedBikini) is discussed. Practical tips on generating tweets and use of visual abstracts are presented, with influence on post-production distribution of journal articles through “tweetorials” and “tweetchats.” Findings from seminal studies on SoMe and the impact on traditional metrics (regular citations) and alternative metrics (Altmetrics, including tweets, retweets, news outlet mentions) are presented. Some concerns on misuse and SoMe caveats are discussed.ConclusionOver the last two decades, social media has had a huge impact on science dissemination, journal article discussions, and presentation of conference news. Immediate and real-time presentation of studies, articles, or presentations has flattened hierarchy for participation, debate, and engagement. Surgeons should learn how to use novel communication technology to advance the field and further professional and public interaction.
The role of ego integrity and despair in older adults’ well-being during the COVID-19 crisis: the mediating role of need-based experiences
Authors: van der Kaap-Deeder Jolene , Vermote Branko , Waterschoot Joachim , Soenens Bart , Morbée Sofie , Vansteenkiste Maarten 
Published: February 2021

AbstractThe COVID-19 pandemic has affected people across the world, with important heterogeneity among older adults in how they respond to the challenges associated with this crisis. Relying on a cross-fertilization between Erikson’s personality theory and self-determination theory, this study aimed to examine possible sources of resilience (i.e., ego integrity and need satisfaction) and vulnerability (i.e., despair) in older adults’ (mal) adjustment, thereby additionally considering the role of multiple risk and protective factors (e.g., gender and marital status). During the second month of the lockdown period in Belgium, 693 older adults (Mage = 70.06, SD = 4.48, range: 65–89 years, 62.1% female) filled out online questionnaires concerning the study variables, while also completing assessments of several important sociodemographic factors. Structural equation modeling suggested that both ego integrity and despair related to indicators of well-being and psychological distress through experienced need satisfaction. Additionally, we found several factors to protect (e.g., higher perceived income) or diminish (e.g., being widowed) older adults’ well-being during these challenging times, with little evidence for a moderating role of these factors in associations between the psychological variables. Theoretical and practical implications of these results are discussed.
The role of disturbance in invasive plant establishment in a changing climate: insights from a drought experiment
Authors: Orbán Ildikó , Szitár Katalin , Kalapos Tibor , Körel-Dulay György 
Published: February 2021

AbstractClimate change and disturbance are two major factors affecting the establishment of invasive species, yet few studies to date have assessed the individual and interactive effects of these two factors in a common setting. Disturbance has often been found to facilitate the establishment of invading species, while climate change may affect them positively or negatively through altering abiotic conditions, or indirectly by modifying species interactions. In a full-factorial field experiment in a semiarid temperate grassland in Central Hungary, we studied the effects of drought (40% rain exclusion throughout the year) and soil disturbance on the emergence, survival and aboveground biomass of four invasive plant species that represent different life forms and that are of concern in the region and at a broader scale. We added seeds of Ambrosia artemisiifolia (annual forb), Cenchrus incertus (annual grass), Asclepias syriaca (perennial forb) and Ailanthus altissima (deciduous tree) in drought and non-drought plots with and without soil disturbance. Ailanthus germinated poorly irrespective of treatments. Disturbance facilitated while drought suppressed seedling emergence in the other three species. Ambrosia was more sensitive to disturbance, while Cenchrus was more responsive to drought. Asclepias achieved substantial emergence in disturbed non-drought plots only, as drought strongly suppressed its emergence even in the presence of disturbance. Seedling survival and late-season aboveground biomass of Ambrosia and Cenchrus were positively affected by disturbance but were unaffected by drought, while no Asclepias seedling survived until late summer. Our results highlight that both drought and disturbance may considerably impact the establishment of invasive plants, with potential interactive effects, but responses may greatly differ among species and life stages. Overall, our findings in this study suggest that although drought may negatively affect seedling establishment, a drier climate may not suppress or eliminate invasive species if soil disturbance is present. They also highlight the importance of including disturbance in studies assessing the potential effects of climate change on plant invasions.
Engaging and Supporting Young Children and their Families in Early Childhood Mental Health Services: The Role of the Family Partner
Authors: Nayak Sameera S. , Tobias Carol , Wolfe Jessica , Roper Kate , Méndez-Peñate Larisa , Moulin Christy , Arty Malika , Scoglio Arielle A. J. , Kelleher Amy , Rue Jacqueline , Brigham Molly , Bradshaw Tarsha , Byars Natasha , Camacho Angelina , Douglas Sade , Molnar Beth E. 
Published: February 2021

AbstractThis study explores the role of family partners, peer professionals with lived experiences of raising a child with behavioral health needs, and their value in primary and community-care based mental health services for young children aged 0–8 years. Interviews and focus groups were conducted with staff, leadership, and caregiver participants (n = 38) from two early childhood mental health programs and analyzed using thematic analysis. Five interdependent themes emerged: (1) the centrality of lived experience to the family partner role; (2) the importance of the family partner in family engagement and relationship building; (3) the value added by the family partner in navigating systems; (4) the ability of the family partner to build skills and empower caregivers; (5) the role of the family partner in alleviating caregiver stress and other mental health concerns. Adapting and expanding the role of family partners will improve effective mental health care for children and their caregivers.
Do transportation network companies increase or decrease transit ridership? Empirical evidence from San Francisco
Authors: Erhardt Gregory D. , Mucci Richard Alexander , Cooper Drew , Sana Bhargava , Chen Mei , Castiglione Joe 
Published: February 2021

AbstractTransportation network companies (TNCs), such as Uber and Lyft, have been hypothesized to both complement and compete with public transit. Existing research on the topic is limited by a lack of detailed data on the timing and location of TNC trips. This study overcomes that limitation by using data scraped from the Application Programming Interfaces of two TNCs, combined with Automated Passenger Count data on transit use and other supporting data. Using a panel data model of the change in bus ridership in San Francisco between 2010 and 2015, and confirming the result with a separate time-series model, we find that TNCs are responsible for a net ridership decline of about 10%, offsetting net gains from other factors such as service increases and population growth. We do not find a statistically significant effect on light rail ridership. Cities and transit agencies should recognize the transit-competitive nature of TNCs as they plan, regulate and operate their transportation systems.
Does Social Capital Affect Voter Turnout? Evidence from Italy
Authors: Fiorino Nadia , Galli Emma , Pontarollo Nicola 
Published: February 2021

AbstractIn this paper we develop a new composite indicator, named Social Catalyst, able to account for the complex and multifaceted nature of the social capital in a unitary measure. We use our indicator, as well as its components, to explore the relation between social capital and electoral participation in the parliamentary elections in Italy from 1994 to 2008, addressing the potential endogeneity bias. Our findings show that (i) the Social Catalyst positively and significantly affects voter turnout in both Chambers; (ii) among the different dimensions of social capital, social norms and associational networks play a prominent role in the Italian regional context.
Dexmedetomidine alleviates pulmonary edema through the epithelial sodium channel (ENaC) via the PI3K/Akt/Nedd4-2 pathway in LPS-induced acute lung injury
Authors: Jiang Yuanxu , Xia Mingzhu , Xu Jing , Huang Qiang , Dai Zhongliang , Zhang Xueping 
Published: February 2021

AbstractDexmedetomidine (Dex), a highly selective α2-adrenergic receptor (α2AR) agonist, has an anti-inflammatory property and can alleviate pulmonary edema in lipopolysaccharide (LPS)-induced acute lung injury (ALI), but the mechanism is still unclear. In this study, we attempted to investigate the effect of Dex on alveolar epithelial sodium channel (ENaC) in the modulation of alveolar fluid clearance (AFC) and the underlying mechanism. Lipopolysaccharide (LPS) was used to induce acute lung injury (ALI) in rats and alveolar epithelial cell injury in A549 cells. In vivo, Dex markedly reduced pulmonary edema induced by LPS through promoting AFC, prevented LPS-induced downregulation of α-, β-, and γ-ENaC expression, attenuated inflammatory cell infiltration in lung tissue, reduced the concentrations of TNF-α, IL-1β, and IL-6, and increased concentrations of IL-10 in bronchoalveolar lavage fluid (BALF). In A549 cells stimulated with LPS, Dex attenuated LPS-mediated cell injury and the downregulation of α-, β-, and γ-ENaC expression. However, all of these effects were blocked by the PI3K inhibitor LY294002, suggesting that the protective role of Dex is PI3K-dependent. Additionally, Dex increased the expression of phosphorylated Akt and reduced the expression of Nedd4-2, while LY294002 reversed the effect of Dex in vivo and in vitro. Furthermore, insulin-like growth factor (IGF)-1, a PI3K agonists, promoted the expression of phosphorylated Akt and reduced the expression of Nedd4-2 in LPS-stimulated A549 cells, indicating that Dex worked through PI3K, and Akt and Nedd4-2 are downstream of PI3K. In conclusion, Dex alleviates pulmonary edema by suppressing inflammatory response in LPS-induced ALI, and the mechanism is partly related to the upregulation of ENaC expression via the PI3K/Akt/Nedd4-2 signaling pathway.
Eosinophil-derived chemokine (hCCL15/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation
Authors: Du Xufei , Li Fei , Zhang Chao , Li Na , Huang Huaqiong , Shao Zhehua , Zhang Min , Zhan Xueqin , He Yicheng , Ju Zhenyu , Li Wen , Chen Zhihua , Ying Songmin , Shen Huahao 
Published: February 2021

AbstractEosinophils are terminally differentiated cells derived from hematopoietic stem cells (HSCs) in the bone marrow. Several studies have confirmed the effective roles of eosinophils in asthmatic airway pathogenesis. However, their regulatory functions have not been well elucidated. Here, increased C-C chemokine ligand 6 (CCL6) in asthmatic mice and the human orthologs CCL15 and CCL23 that are highly expressed in asthma patients are described, which are mainly derived from eosinophils. UsingCcl6knockout mice, further studies revealed CCL6-dependent allergic airway inflammation and committed eosinophilia in the bone marrow following ovalbumin (OVA) challenge and identified a CCL6-CCR1 regulatory axis in hematopoietic stem cells (HSCs). Eosinophil differentiation and airway inflammation were remarkably decreased by the specific CCR1 antagonist BX471. Thus, the study identifies that the CCL6-CCR1 axis is involved in the crosstalk between eosinophils and HSCs during the development of allergic airway inflammation, which also reveals a potential therapeutic strategy for targeting G protein-coupled receptors (GPCRs) for future clinical treatment of asthma.
Strategies for Optic Pathways Decompression for Extra-Axial Tumors or Intracranial Aneurysms: A Technical Note
Authors: Mattogno Pier Paolo , Sturiale Carmelo Lucio , Rapisarda Alessandro , Olivi Alessandro , Albanese Alessio 
Published: February 2021

Abstract
Background Different types of skull base tumors and intracranial aneurysms may lead to compression of the optic pathways. Since most of them are biologically benign conditions, the first aim of surgery is preservation of optic nerves rather than the oncologic radicality.
Materials and methods Based on the progressive technical refinements coming from our institutional experience of optic nerve compression from aneurysms and extra-axial tumors, we analyzed the surgical steps to release nerves and chiasm during tumor debulking and aneurysm clipping.
Results We distinguished vascular and tumor lesions according to the main direction of optic nerve compression: lateral to medial, medial to lateral, inferior to superior, and anterior to posterior. We also identified four fundamental sequential maneuvers to release the optic nerve, which are (1) falciform ligament (FL) section, (2) optic canal unroofing, (3) anterior clinoid process drilling, and (4) optic strut removal. The FL section is always recommended when a gentle manipulation of the optic nerve is required. Optic canal unroofing is suggested in case of lateral-to-medial compression (i.e., clinoid meningiomas), medial-to-lateral compression (i.e., tuberculum sellae meningiomas), and inferior-to-superior compression (i.e., suprasellar lesions). Anterior clinoidectomy and optic strut removal may be necessary in case of lateral-to-medial compression from paraclinoid aneurysms or meningiomas.
Conclusions Preservation of the visual function is the main goal of surgery for tumors and aneurysms causing optic nerve compression. This mandatory principle guides the approach, the timing, and the technical strategy to release the optic nerve, and is principally based on the direction of the compression vector.
Ex Vivo Prediction of Comprehensive Coagulation Potential Using Simulated Blood Concentrations of Emicizumab in Patients with Acquired Hemophilia A
Authors: Takeyama Masahiro , Furukawa Shoko , Yada Koji , Ogiwara Kenichi , Shimonishi Naruto , Nakajima Yuto , Mizumachi Kuniyoshi , Noguchi-Sasaki Mariko , Shima Midori , Nogami Keiji 
Published: February 2021

Abstract
Introduction Emicizumab prophylaxis improves coagulation function in congenital hemophilia A, regardless of inhibitor presence. We recently reported that emicizumab enhanced the coagulant potentials, ex vivo, in plasmas from patients with acquired hemophilia A (PwAHAs) at diagnosis. However, coagulant effects of emicizumab in PwAHAs during the clinical course remain unclear.
Aim To assess ex vivo coagulant effects of emicizumab in PwAHAs during the clinical course.
Methods/Results Blood samples were obtained from 14 PwAHAs on (median) days 0 and 6 during a severe-bleeding phase, and days 27 and 59 during a reduced-bleeding phase with elevated endogenous factor VIII (FVIII) and decreased inhibitor titers. If administered a single dose of 3 or 6 mg/kg, or two doses at 6 mg/kg followed by 3 mg/kg, estimated plasma emicizumab concentrations (10/5/2.5, 20/10/5, and 30/15/7.5 µg/mL on days 0–7/30/60, respectively) could be used to represent potential changes, based on the half-life (T
1/2: ∼30 days). Emicizumab concentrations that covered maximum plasma concentrations of each dosage were used for spiking on day 0. Ex vivo addition of estimated emicizumab to PwAHA's plasma containing endogenous FVIII and/or inhibitor, without and with recombinant (r)FVIIa administration during immunosuppressive therapy, increased the calculated Ad|min1| values, assessed by clot waveform analysis, and their coagulant potentials were below normal levels. Rotational thromboelastometry revealed that ex vivo emicizumab addition resulted in the further improvement of coagulant potentials in whole bloods when combined with rFVIIa administration.
Conclusion Based on ex vivo and in vitro data, emicizumab has the potential to be effective in clinical situations for PwAHAs.
Trends in Acute Pulmonary Embolism Admission Rates and Mortality Outcomes in Australia, 2002–2003 to 2017–2018: A Retrospective Cohort Study
Authors: Hoskin Scott , Brieger David , Chow Vincent , Kritharides Leonard , Ng Austin Chin Chwan 
Published: February 2021

Abstract
Background Contemporary Australian epidemiological data on acute pulmonary embolism (PE) are lacking.
Objectives To determine the admission rates of acute PE in Australia, and to assess the temporal trends in short- and medium-term mortality following acute PE.
Methods Retrospective population-linkage study of all New South Wales residents admitted with a primary diagnosis of PE between January 1, 2002 and December 31, 2018 using data from the Centre for Health Record Linkage databases. Main outcome measures included temporal trends in total PE admissions and all-cause mortality at prespecified time points up to 1 year, stratified by gender.
Results There were 61,607 total PE admissions between 2002 and 2018 (mean ± standard deviation: 3,624 ± 429 admissions per annum; 50.42 ± 3.70 admissions per 100,000 persons per annum). The mean admission rate per annum was higher for females than for males (54.85 ± 3.65 vs. 44.91 ± 4.34 admissions per 100,000 persons per annum, respectively) and remained relatively stable for both genders throughout the study period. The main study cohort, limited to index PE admission only, comprised 46,382 persons (mean age: 64.6 ± 17.3 years; 44.4% males). The cumulative in-hospital, 30-day, 3-month, and 1-year mortality rates were 3.7, 5.6, 9.6, and 16.8%, respectively. When compared with 2002 as the reference year, there was a significant reduction in in-hospital (odds ratio [OR] = 0.34; 95% confidence interval [CI] = 0.25–0.46), 30-day (OR = 0.58, 95% CI = 0.46–0.73), and 1-year (hazard ratio = 0.74, 95% CI = 0.66–0.84) (all p < 0.001) mortality risk by 2017 after adjusting for age, gender, and relevant confounders. The survival improvements were seen in both genders and were greater for females than for males.
Conclusion Mortality following PE has improved with reductions observed in both short- and medium-term follow-ups between 2002 and 2018 with greater reductions in females despite their higher admission rates over time.
Archiving the Chilean Revolution
Authors: Ragas José 
Published: February 2021

Abstract
In October 2019, Santiago de Chile became the epicenter of a violent and massive protest against social inequality. Known as the Estallido Social (the Social Unrest), Chileans took to the streets seeking to dismantle the pervasive social and economic system inherited from Augusto Pinochet’s regime established half a century ago. Drawing from participant observations and interviews conducted during the protest, this essay examines the multiple efforts developed by scholars to document the vast repertoire of material generated during Santiago’s demonstrations (e.g., graffiti, signs, flags, testimonies, and merchandise). In doing so, I aim to situate the Estallido Social within the recent efforts deployed by museums, archives, and libraries to capture the changing nature and manifestations of global protests in the past few years.