bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Globalization on Entrepreneurial Revitalization of Main Urban Areas - Case of Croatia
Authors: Hruška Domagoj , Luković Tihomir , Piplica Damir 
Published: January 2021

Research background:The paper argues how the sustainable development of entrepreneurship in urban areas is based on four cornerstones: corruption, size of urban areas, industrial structure and cultural biases. Corruption is a significant social and economic issue that has crippling effect for entrepreneurship. Further on, the superiority of larger cities in generating advanced economies has been recognized since the time of the ancient Greek and medieval Italian city-states, however it is not clear if the same is applicable today as well. Third cornerstone of entrepreneurial development in main urban areas is the industrial structure of these areas. Lastly, the values that drive entrepreneurial action and form entrepreneurial environments are embedded in wider national culture.Purpose of the article:The aim of the paper is to investigate and describe pivotal influences on entrepreneurial activity as an impetus of sustainable economic development in globalized environment of transition economy urban areas.Methods:The four factors that influence the level of sustainable development of entrepreneurship in urban areas: level of perceived corruption, size of urban areas, industrial structure and cultural biases are described as well as the correlation between level of entrepreneurial activity and each of these crucial elements of urban revitalization.Findings & Value added:By examining antecedents and consequences of economic and social circumstances that define environment for fostering entrepreneurial activity in main urban areas in Croatia the paper provides comprehensive tool for strategy development that can be used by policy makers and entrepreneurs alike.
Progress in Sustainable Consumption and Production in Slovakia in Comparison with other EU Countries – Energy Intensity of the Sector
Authors: Rybárová Daniela 
Published: January 2021

Research background: Problematic of sustainable consumption and production is a broad conception that is integrating application of advanced methods and techniques of business management, in all areas, including eco-design and innovation, sustainable marketing, risk management and strategic management with a focus on sustainable development for the environment. The European Union has established numerous strategies to support it, the success of which depends on building a sufficient awareness and above all the involvement of all countries in the process of improving the environmental performance of products throughout their life cycle. Building of sustainable consumption and production on the widest scale is influenced by the social and economic dimension, which awareness and understanding makes it possible to encourage and motivate to socially responsible behaviour. In order to face the current challenges, it is essential to change the way we produce and consume.
Purpose of the article: Analyse the financial and economic parameters of selected sectors in dependence on the fulfilment of selected indicators that are measuring progress in sustainable consumption and production in Slovakia in comparison with other EU countries
Methods: Time series analysis, spatial analysis.
Findings & Value added: Systematizing the ways to measure progress in achieving sustainable consumption and production with regards to defined indicators in strategies, policies and action plans of EU following the structure of national economies.
Comparison of The Possibilities of Application of Spectrum and Gaming Theories in Modelling Market Economy Negotiations
Authors: Peleckis Kęstutis , Peleckiene Valentina , Peleckis Kęstutis 
Published: January 2021

Research background: In negotiations, in modelling decision-making at both the individual and market levels, it is important to understand and be able to assess important aspects of economic behaviour. The theory of spectrum is proposed to be applied in modelling decision making. The object of the research is the possibilities of application of spectrum and game theories. Classical economic theory does not define subjective parameters of economic behaviour, therefore, when modelling market negotiation strategies, it is difficult to identify and evaluate appropriate parameters of economic behaviour required for decision-making in market negotiations. The spectrum theory approach can be used to model the economy, both at the individual and market levels, which is especially relevant in international business negotiations, where the modelling of solutions and various operations presents opportunities to assess subjective parameters.
Purpose of the article: The aim of the paper is to investigate and compare the application of spectral decay and gambling theories in modelling market economy negotiations.
Research methods: Scientific literature analysis, comparative, logical analysis and synthesis, comparative and generalization methods, game theory, quantum cognition methods.
Findings & Value added: The article examines the basic principles of behavioural economics: the functions of assessing the psychological value and uncertainty of monetary gain or loss, how both theories take these principles into account: game and spectrum.
Determining the dependence of supplementary charges in the ZSSK CARGO tariff in the context of the customer approach, competitiveness, and globalization
Authors: Šperka Adrián , Čamaj Juraj , Zmeškal Ekaterina , Majerčák Jozef 
Published: January 2021

Research background: The article deals with the study of the dependencies of selected supplementary charges in rail freight transport. In the environment of a globalized society, it is very important that railway undertakings maintain their competitiveness in an open market. The article is part of a case study that deals with the development of pricing. The research was primarily focused on the structure and development of the price of supplementary charges in the years 2004 – 2020 at Železničná Spoločnosť Cargo Slovakia, j. s. c.
Purpose of the article: Based on two selected supplementary charges, and the hypothesis of whether or not the development of their price is dependent will be verified by means of regression analysis. The aim of the research is to point out of the disproportionate increase in the prices of supplementary charge, which form a significant part of the calculation of the price for transportation. And for most customers it is a priority for the price of transport.
Methods: The article will use a simple regression analysis according to the relationships depending on the type of dependence used (linear, polynomial, ...)
Findings & Value added: The results of the research can help to better set the structure of supplementary charges. The goal of the company should be a satisfied customer and a dominant market share.
Primäre Feldwespengiftallergie im Rheingau: selten oder vielleicht doch nicht so selten?
Authors: Adib-Tezer H. , Bayerl C. 
Published: January 2021

ZusammenfassungDie Hymenopterengiftallergie ist der häufigste Auslöser anaphylaktischer Reaktionen bei Erwachsenen und der zweithäufigste Auslöser bei Kindern nach den Nahrungsmitteln. In West- und Mitteleuropa sind Stiche der Faltenwespenarten Vespula vulgaris und Vespula germanica sowie der Honigbiene Apis mellifera die Hauptauslöser von Anaphylaxien. In Südeuropa, den USA sowie in tropischen und subtropischen Gebieten (v. a. Südamerika) sind Feldwespenarten (Polistes spp.) weit verbreitet und spielen dort als Auslöser von Stichanaphylaxien eine bedeutende Rolle.Dargestellt wird der außergewöhnliche Fall einer primären Feldwespengiftallergie bei einem 65-jährigen Patienten aus dem Rheingau. Da die Feldwespengift-Immuntherapie in Deutschland keine Zulassung hat, konnte diese unserem Patienten als kausale Therapie nicht angeboten werden. Durch die klimatischen Veränderungen könnte die Feldwespengiftallergie sowohl aktuell als auch zukünftig in Nord- und Westeuropa eine wichtige Rolle einnehmen.
Segmental Neurofibromatosis
Authors: Raju Dimble , Ghosh Nabanita , Das Sayan , Krishnan Prasad 
Published: January 2021

Abstract
Segmental neurofibromas are the rarest variant of neurofibromatosis. We describe one such case in a 34-year-old man with multiple subcutaneous swellings in the posterior aspect of the left lower limb.
Primary Headache Associated with Sexual Activity in Adolescents: Illustrative Cases
Authors: Patel Jinal , Rothner David A. 
Published: January 2021

AbstractPrimary headache associated with sexual activity (PHASA) is well described in adults, but reports in adolescents are lacking. PHASA is likely underreported in adolescents. A delay in or an absence of timely and adequate treatment has the potential to negatively impact normal adolescent psychosexual development. Physicians should consider this disorder in adolescents presenting with headaches, and understand the characteristics, diagnosis, and treatment. We reported two cases of PHASA in adolescents and review the epidemiology, presentation, and management.
Niemann-Pick Disease Type C with Isolated Splenomegaly: A Case Report in a Child
Authors: Torres Bruna Ribeiro , Russo Daniela Otoni , Vuolo Vinícius Andrade Gomes , Borborema Tarcísio Silva , Barbosa André Vinícius Soares , Diniz Lílian Martins Oliveira 
Published: January 2021

AbstractNiemann-Pick disease type C is an innate error of lysosomal storage metabolism with an autosomal recessive inheritance pattern. The disease causes intracellular cholesterol accumulation and changes in sphingolipid metabolism. If cholesterol accumulates, the signs and symptoms of visceral involvement predominate. Neurological involvement results from sphingolipid accumulation. A 7-year-old male patient was referred to a tertiary service for the investigation of asymptomatic splenomegaly. Following an extensive examination, he was diagnosed with Niemann-Pick disease type C. Interestingly, this case's only symptom was splenomegaly.
Acute Arterial Ischemic Stroke in a Treated Child with Hunter's Syndrome: A Case Report and Review of the Literature
Authors: Sharma Kamal , Cummock Joshua , Maertens Paul 
Published: January 2021

AbstractEnzyme replacement therapy (ERT) has limited therapeutic effects on neurologic, skeletal, and cardiovascular pathophysiology. We report an acute right-sided flaccid hemiparesis in an 11-year-old boy with the severe neuronopathic phenotype of Hunter's syndrome who was receiving weekly idursulfase ERT. Due to his psychomotor regression and epilepsy, his presentation to the hospital was delayed. Computed tomography scan of brain showed no acute changes or hemorrhage. Stroke code was not called as patient was already outside of the time window for tissue plasminogen activator (tPA) therapy. Brain magnetic resonance imaging (MRI) showed diffuse cortical and deep atrophy consistent with his baseline neurological status and restricted diffusion in the territory of the left-middle cerebral artery (MCA) consistent with recent infarction. T1-weighted MRI revealed low signal intensity of the left insular cortex, as well as volume loss, consistent with previous undiagnosed stroke in the same vascular territory. In addition, MR angiogram (MRA) demonstrated left terminal M1 segment MCA occlusion. Echocardiogram showed aortic root dilation and moderate aortic valve insufficiency. Patient was also noted to have bacteremia related to port infection. ERT is limited by blood–brain barrier and the underlying glycosaminoglycans (GAGs) extracellular tissue accumulation which produces a proinflammatory state. GAG and bacterial lipopolysaccharide (LPS) are known to activate toll-like receptor 4 (TLR-4). GAGs released in the extracellular space of intracranial vessels induce inflammation by activating the TLR-4 pathway which is exacerbated by bacterial LPS contributing to focal arteritis. Our case suggests the importance of GAGs in the activation of the TLR-4 pathway as a cause of stroke in Hunter's syndrome.
Cerebral Infarction in Immune Thrombotic Thrombocytopenic Purpura Is Associated with Old Age, Hypertension, Smoking, and Anti-ADAMTS13 Ig, But Not with Mortality
Authors: Memon Raima , Sui Jingrui , Lin Chen , Zheng X. Long 
Published: January 2021

Abstract
Background Neurological involvement is common in patients with immune thrombotic thrombocytopenic purpura (iTTP), but the frequency, risk factors, and outcomes of these with imaging-confirmed stroke in iTTP are not known.
Methods We selected 66 out of 109 iTTP patients with neurological signs and symptoms and reviewed their CT/MRI (computed tomography/magnetic resonance imaging) findings for the evidence of stroke and other clinical information in Alabama TTP Registry.
Results Of these, 52 (78.8%) had their CT/MRI done on admission in whom 22 (42.3%) were positive for multiple acute or chronic infarcts. The patients with image-confirmed ischemic stroke were older, and appeared to be associated with a history of hypertension and smoking. Additionally, patients with imaging-confirmed stroke showed higher plasma concentrations of anti-ADAMTS13 IgG than those without stroke. More interestingly, there was no statistically significant difference in the rate of exacerbation and 60-day mortality between those with and without stroke.
Conclusion Ischemic cerebral infarcts are common findings in brain imaging studies of patients with acute iTTP; old age, chronic hypertension, and smoking, as well as high plasma concentrations of anti-ADAMTS13 IgG may be the potential risk factors for cerebral infarction in these patients. The presence of image-confirmed ischemic stroke, however, does not predict exacerbation and 60-day mortality, although the long-term effect of such ischemic brain damage on cognitive function and quality of life remains to be determined.
Organic horticulture.
Authors: Dorais Martine 
Published: January 2021

Abstract

Organic agriculture, also called biological or ecological agriculture, is defined by the International Federation of Organic Agricultural Movements (IFOAM) as a "production system that sustains the health of soils, ecosystems and people" (http://www.ifoam.org). It is known as an environmental-friendly production system that integrates traditional, modern and innovative techniques in order to promote biodiversity, biological cycles and soil biological activity, with minimal use of off-farm inputs. Consequently, organic agriculture is aiming at cultural practices that will maintain or improve soil health, have a sustainable water and waste management, limit the use of fossil energy, adopt nutrient-balanced approaches to limit nutrient leaching into ground water and soil salinization and endorse mechanical and biological control of pests. Organic horticulture ranges from strict in farm-closed systems limiting external inputs to its minimum level, to systems that only follow the organic certification standards. From a broader perspective, organic horticulture should contribute to the global challenges via the nutrition security and the well-being of the populations (Alsanius et al., 2016). It should also be economically viable, socially fair, culturally diverse, transparently accountable and inclusive (Arbenz et al., 2016). Organic agriculture usually provides higher ecosystem services and social benefits as compared to conventional farming (Reganold and Wachter, 2016).
Key comparison BIPM.RI(I)-K1 of the air-kerma standards of the BEV, Austria and the BIPM in 60Co gamma radiation
Authors: Kessler C , Burns D , Steurer A , Tiefenboeck W , Merza V 
Published: January 2021

Main text
A new key comparison of the standards for air kerma of the Bundesamt f¨r Eich- und Vermessungswesen (BEV), Austria and of the Bureau International des Poids et Mesures (BIPM) was carried out in the 60Co radiation beam of the BIPM in July 2020. The comparison result, evaluated as a ratio of the BEV and the BIPM standards for air kerma, is 1.0030 with a combined standard uncertainty of 2.5 parts in 103. The result agrees within the uncertainties with the direct comparison carried out in 2009. The results are analysed and presented in terms of degrees of equivalence, suitable for entry in the BIPM key comparison database.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Tunable co-doped dye laser of coumarin 440 and coumarin 460
Authors: Wang Can , Feng Ce , Lu Zhenzhong 
Published: January 2021

Abstract
The laser performance of coumarin 440 (C440) and coumarin 460 (C460) mixture is studied. The mixture dyes demonstrated broader and more efficient tuning curves compared with those of coumarin 440 and coumarin 460. A wide tuning range from 421 nm to 482 nm is achieved. The highest conversion efficiency of 12.2% is obtained at 453 nm. Comparing with the efficiencies of individual dye C440 and C460, which are ∼5%, the tuning range and the conversion efficiency of the coumarin 440 (C440) and coumarin 460 (C460) mixture are the best under the same condition so far. All our results indicate that high laser performance can be achieved using the co-doped laser dyes of coumarin 440 and coumarin 460.
Getting the Most From Surveys: How Method Selection and Method Modification Impact Butterfly Survey Data
Authors: Kral-O’Brien Katherine C , Antonsen Adrienne K , Hovick Torre J , Limb Ryan F , Harmon Jason P 
Published: January 2021

AbstractMany methods are used to survey butterfly populations, with line transect and area surveys being prominent. Observers are typically limited to search within 5 or 10 m from the line, while observers are unrestricted in larger specified search regions in area surveys. Although methods differ slightly, the selection is often based on producing defendable data for conservation, maximizing data quality, and minimizing effort. To guide method selection, we compared butterfly surveys using 1) line versus area methods and 2) varying width transects (5 m, 10 m, or unrestricted) using count data from surveys in North Dakota from 2015 to 2018. Between line and area surveys, we detected more individuals with area surveys, even when accounting for effort. However, both methods accumulated new species at similar rates. When comparing transect methodology, we detected nearly 60% more individuals and nine more species when transect width increased from 5 m to unrestricted, despite similar effort across methodology. Overall, we found line surveys slightly less efficient at detecting individuals, but they collected similar species richness to area surveys when accounting for effort. Additionally, line surveys allow the use of unrestricted-width transects with distance sampling procedures, which were more effective at detecting species and individuals while providing a means to correct count data over the same transect length. Methods that reduce effort and accurately depict communities are especially important for conservation when long-term datasets are unavailable.
Semisynthesis of prunetin, a bioactive O-methylated isoflavone from naringenin, by the sequential deacetylation of chalcone intermediates and oxidative rearrangement
Authors: Sugai Takeshi , Hanaya Kengo , Higashibayashi Shuhei 
Published: January 2021

Abstract
Prunetin (4′,5-dihydroxy-7-methoxyisoflavone) was semisynthesized in 8 steps from readily available naringenin in 26% total yield. The key reaction was chemoenzymatic sequential deacetylation to 6′-acetoxy-2′,4″-dihydroxy-4′-methoxychalcone, the in situ-formed precursor for thallium(III) nitrate-mediated oxidative rearrangement.
One-pot enzymatic synthesis of 2-deoxy-scyllo-inosose from d-glucose and polyphosphate
Authors: Kudo Fumitaka , Mori Ayaka , Koide Mai , Yajima Ryo , Takeishi Ryohei , Miyanaga Akimasa , Eguchi Tadashi 
Published: January 2021

Abstract
2-Deoxy-scyllo-inosose (2DOI, [2S,3R,4S,5R]-2,3,4,5-tetrahydroxycyclohexan-1-one) is a biosynthetic intermediate of 2-deoxystreptamine-containing aminoglycoside antibiotics, including butirosin, kanamycin, and neomycin. In producer microorganisms, 2DOI is constructed from d-glucose 6-phosphate (G6P) by 2-deoxy-scyllo-inosose synthase (DOIS) with the oxidized form of nicotinamide adenine dinucleotide (NAD+). 2DOI is also known as a sustainable biomaterial for production of aromatic compounds and a chiral cyclohexane synthon. In this study, a one-pot enzymatic synthesis of 2DOI from d-glucose and polyphosphate was investigated. First, 3 polyphosphate glucokinases (PPGKs) were examined to produce G6P from d-glucose and polyphosphate. A PPGK derived from Corynebacterium glutamicum (cgPPGK) was found to be suitable for G6P production under ordinary enzymatic conditions. Next, 7 DOISs were examined for the one-pot enzymatic reaction. As a result, cgPPGK and BtrC, the latter of which is a DOIS derived from the butirosin producer Bacillus circulans, achieved nearly full conversion of d-glucose to 2DOI in the presence of polyphosphate.
Recent applications of N-acyl imidazole chemistry in chemical biology
Authors: Mino Takeharu , Sakamoto Seiji , Hamachi Itaru 
Published: January 2021

Abstract
N-Acyl imidazoles are unique electrophiles that exhibit moderate reactivity, relatively long-half life, and high solubility in water. Thanks to their tunable reactivity and chemical selectivity, the application of N-acyl imidazole derivatives has launched to a number of chemical biology researches, which include chemical synthesis of peptide/protein, chemical labeling of native proteins of interest (POIs), and structural analysis and functional manipulation of RNAs. Since proteins and RNAs play pivotal roles in numerous biological events in all living organisms, the methods that enable the chemical modification of endogenously existing POIs and RNAs in live cells may offer a variety of opportunities not only for fundamental scientific study but also for biotechnology and drug development. In this review, we discuss the recent progress of N-acyl imidazole chemistry that contributes to the chemical labeling and functional control of endogenous proteins and RNAs under multimolecularly crowded biological conditions of live cells.
Recent advances in the total syntheses of indole diterpenoids
Authors: Enomoto Masaru 
Published: January 2021

Abstract
Indole diterpenoids constitute a large family of natural products that are characterized by a hybrid molecular architecture consisting of an indole nucleus and diterpenoid moiety. Their pharmacologically and agriculturally important biological properties as well as intriguing molecular architectures have attracted much attention from many synthetic organic chemists. In 2012, we succeeded in the concise total synthesis of a paspalane-type indole diterpenoid, namely paspalinine, by developing a highly efficient indole ring formation protocol. After the report of this total synthesis, 4 research groups achieved the total syntheses of other paspalane- and nodulisporane-type indole diterpenoids using current state-of-the-art methods. This review summarizes the total syntheses of the paspalane- and nodulisporane-type indole diterpenoids that were described in the last 10 years.