bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of Novel Methylation-Driven Gene Model and Investigation of PARVB Function in Glioblastoma
Authors: Yu Wanli , Wu Pengfei , Wang Fang , Miao Li , Han Bo , Jiang Zhiqun 
Published: September 2021

BackgroundGlioblastoma multiforme (GBM) is characterized by widespread genetic and transcriptional heterogeneity. Aberrant DNA methylation plays a vital role in GBM progression by regulating gene expression. However, little is known about the role of methylation and its association with prognosis in GBM. Our aim was to explore DNA methylation-driven genes (DMDGs) and provide evidence for survival prediction and individualized treatment of GBM patients.MethodsUse of the MethylMix R package identified DMDGs in GBM. The prognostic signature of DMDGs based on the risk score was constructed by multivariate Cox regression analysis. Receiver operating characteristics (ROC) curve and C-index were applied to assess the predictive performance of the DMDG prognostic signature. The predictive ability of the multigene signature model was validated in TCGA and CGGA cohorts. Finally, the role of DMDG β-Parvin (PARVB) was explored in vitro.ResultsThe prognostic signature of DMDGs was constructed based on six genes (MDK, NMNAT3, PDPN, PARVB, SERPINB1, and UPP1). The low-risk cohort had significantly better survival than the high-risk cohort (p &lt; 0.001). The area under the curve of the ROC of the six-gene signature was 0.832, 0.927, and 0.980 within 1, 2, and 3 years, respectively. The C-index of 0.704 indicated superior specificity and sensitivity. The six-gene model has been demonstrated to be an independent prognostic factor for GBM. In addition, joint survival analysis indicated that the MDK, NMNAT3, PARVB, SERPINB1, and UPP1 genes were significantly associated with prognosis and therapeutic targets for GBM. Importantly, our DMDG prognostic model was more suitable and accurate for low-grade gliomas. Finally, we verified that PARVB induced epithelial-mesenchymal transition partially through the JAK2/STAT3 pathway, which in turn promoted GBM cell proliferation, migration, and invasion.ConclusionThis study demonstrated the potential value of the prognostic signature of DMDGs and provided important bioinformatic and potential therapeutic target data to facilitate individualized treatment for GBM, and to elucidate the specific mechanism by which PARVB promotes GBM progression.
A Multicentric Randomized Trial to Evaluate the ROle of Uterine MANipulator on Laparoscopic/Robotic HYsterectomy for the Treatment of Early-Stage Endometrial Cancer: The ROMANHY Trial
Authors: Gueli Alletti Salvatore , Perrone Emanuele , Fedele Camilla , Cianci Stefano , Pasciuto Tina , Chiantera Vito , Uccella Stefano , Ercoli Alfredo , Vizzielli Giuseppe , Fagotti Anna , Gallotta Valerio , Cosentino Francesco , Costantini Barbara , Restaino Stefano , Monterossi Giorgia , Rosati Andrea , Turco Luigi Carlo , Capozzi Vito Andrea , Fanfani Francesco , Scambia Giovanni 
Published: September 2021

ObjectiveThis prospective randomized trial aimed to assess the impact of the uterine manipulator in terms of lymph vascular space invasion (LVSI) in patients undergoing minimally invasive staging for early-stage endometrial cancer.MethodsIn this multicentric randomized trial, enrolled patients were randomly allocated in two groups according to the no use (arm A) or the use (arm B) of the uterine manipulator. Inclusion criteria were G1-G2 early-stage endometrial cancer at preoperative evaluation. The variables collected included baseline demographic characteristics, perioperative data, final pathology report, adjuvant treatment, and follow-up.ResultsIn the study, 154 patients (76 in arm A and 78 in arm B) were finally included. No significant differences were recorded regarding the baseline characteristics. A statistically significant difference was found in operative time for the laparoscopic staging (p=0.005), while no differences were reported for the robotic procedures (p=0.419). The estimated blood loss was significantly lower in arm A (p=0.030). No statistically significant differences were recorded between the two study groups in terms of peritoneal cytology, LVSI (p=0.501), and pattern of LVSI (p=0.790). No differences were detected in terms of overall survival and disease-free survival (p=0.996 and p=0.480, respectively). Similarly, no differences were recorded in the number of recurrences, 6 (7.9%) in arm A and 4 (5.2%) in arm B (p=0.486). The use of the uterine manipulator had no impact on DFS both at univariable and multivariable analyses.ConclusionsThe intrauterine manipulator does not affect the LVSI in early-stage endometrial cancer patients undergoing laparoscopic/robotic staging.Clinical Trial Registrationhttps://clinicaltrials.gov, identifier (NCT: 02762214)
Urinary Exosomes Diagnosis of Urological Tumors: A Systematic Review and Meta-Analysis
Authors: Xu Yipeng , Lou Jianmin , Yu Mingke , Jiang Yingjun , Xu Han , Huang Yueyu , Gao Yun , Wang Hua , Li Guorong , Wang Zongping , Zhao An 
Published: September 2021

PurposeExosomes could be released directly into the urine by the urological tumoral cells, so testing urinary exosomes has great potential for non-invasive diagnosis and monitor of urological tumors. The objective of this study is to systematically review and meta-analysis of urinary exosome for urological tumors diagnosis.Materials and MethodsA systematic review of the recent English-language literature was conducted according to the PRISMA statement recommendations (CRD42021250613) using PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases up to April 30, 2021. Risk-of-bias assessment was performed according to the QUADAS 2 tool. The true diagnostic value of urinary exosomes by calculating the number of true positive, false positive, true negative, and false negative, diagnoses by extracting specificity and sensitivity data from the selected literature.ResultsSixteen eligible studies enrolling 3224 patients were identified. The pooled sensitivity and specificity of urinary exosomes as a diagnostic tool in urological tumors were 83% and 88%, respectively. The area under the summary receiver operating characteristic curve was 0.92 (95% CI: 0.89–0.94). Further subgroup analyses showed that our results were stable irrespective of the urinary exosome content type and tumor type.ConclusionUrinary exosomes may serve as novel non-invasive biomarkers for urological cancer detection. Future clinical trial designs must validate and explore their utility in treatment decision-making.Systematic Review Registration[
https://www.crd.york.ac.uk/prospero/], identifier [CRD42021250613].
Predictors of Prenatal Depression: A Cross-Sectional Study in Rural Pakistan
Authors: Khan Rukhsana , Waqas Ahmed , Mustehsan Zille Huma , Khan Amna Saeed , Sikander Siham , Ahmad Ikhlaq , Jamil Anam , Sharif Maria , Bilal Samina , Zulfiqar Shafaq , Bibi Amina , Rahman Atif 
Published: September 2021

Objective: To determine the prevalence and association of prenatal depression with socioeconomic, demographic and personal factors among pregnant women living in Kallar Syedan, Rawalpindi, Pakistan.Methods: Five hundred women in the second and third trimester of pregnancy, living in Kallar Syedan, a rural area of district Rawalpindi Pakistan, were included in the study. Depression was assessed using “Patient health questionnaire” (PHQ9) in Urdu, with a cut-off score of 10. Multi-dimensional scale of perceived social support (MSPSS) was used to assess perceived social support. Life Events and Difficulties Schedule (LEDS) were used to measure stressful life events in past 1 year. Tool to assess intimate partner violence (IPV) was based on WHO Multi Country Study on “Women's Health and Domestic Violence against Women.”Results: Prevalence of prenatal depression was found to be 27%. Number of pregnancies was significantly associated with prenatal depression (p &lt; 0.01). Women living in a joint family and those who perceived themselves as moderately satisfied or not satisfied with their life in the next 4 years were found to be depressed (p &lt; 0.01, OR 6.9, CI 1.77–26.73). Depressive symptomatology in women who experienced more than five stressful life events in last 1 year was three times higher (p &lt; 0.001, OR 3.2, CI 1.68–5.98) than in women with 1–2 stressful events. Women who were supported by their significant others or their family members had 0.9 times (p &lt; 0.01, OR 0.9, CI 0.85–0.96) less chance of getting depressed. Pregnant women who were psychologically abused by their partners were 1.5 times more depressed (p &lt; 0.05 CI 1.12–2.51). Odds of having depression was also high in women who had less mean score of MSSI (p &lt; 0.05, OR 1.1, CI 1.01–1.09). Women who had suitable accommodation had 0.5 times less chance of having depression than others (p &lt; 0.05, OR 0.5, CI 0.27–0.92).Conclusion: Over a quarter of the women in the study population reported prenatal depression, which were predicted predominantly by psychosocial variables.
Case Report: 21 Cases of Umbilical Hernia Repair Using a Laparoscopic Cephalic Approach Plus a Posterior Sheath and Extraperitoneal Approach
Authors: Zhang Kunjie , Qin Mingfang , Ding Guoqian 
Published: September 2021

Purpose: In this study, a novel surgical technique was developed for umbilical hernias, in which a laparoscopic cephalic approach plus a posterior sheath and an extraperitoneal approach was employed. The aim of this study was to determine the results of this new technique.Methods: From 2019 to 2020, 21 patients (81.8% men) with an umbilical hernia underwent a laparoscopic cephalic approach plus a posterior sheath and extraperitoneal approach, performed by two surgeons specializing in abdominal wall surgery, in two academic hospitals. Intraoperative and postoperative complications, operation time, blood loss, and hernia recurrence were assessed.Results: Twenty-one cases of umbilical hernia were successfully completed. The size of the hernia ring was 1.5–3 cm2, with an average of 2.39 ± 0.47 cm2. The operation time was 120–240 min (average, 177.3 ± 42.15 min), and the blood loss volume was 30–40 ml (average, 33.73 ± 3.55 ml). The mean follow-up period was 6 months, and there were no short-term complications and no cases of recurrence.Conclusion: A laparoscopic cephalic approach plus a posterior sheath and extraperitoneal approach is a safe alternative for the repair of an umbilical hernia. The intraoperative complication rate was low.
The Value of Magnetic Resonance Imaging Histograms in the Preoperative Differential Diagnosis of Endometrial Stromal Sarcoma and Degenerative Hysteromyoma
Authors: Zhang Xiao-Nan , Bai Man , Ma Ke-Ran , Zhang Yong , Song Cheng-Ru , Zhang Zan-Xia , Cheng Jing-Liang 
Published: September 2021

Objective: The present study aimed to explore the application value of magnetic resonance imaging (MRI) histograms with multiple sequences in the preoperative differential diagnosis of endometrial stromal sarcoma (ESS) and degenerative hysteromyoma (DH).Methods: The clinical and preoperative MRI data of 20 patients with pathologically confirmed ESS and 24 patients with pathologically confirmed DH were retrospectively analyzed, forming the two study groups. Mazda software was used to select the MRI layer with the largest tumor diameter in T2WI, the apparent diffusion coefficient (ADC), and enhanced T1WI (T1CE) images. The region of interest (ROI) was outlined for gray-scale histogram analysis. Nine parameters—the mean, variance, kurtosis, skewness, 1st percentile, 10th percentile, 50th percentile, 90th percentile, and 99th percentile—were obtained for intergroup analysis, and the receiver operating curves (ROCs) were plotted to analyze the differential diagnostic efficacy for each parameter.Results: In the T2WI histogram, the differences between the two groups in seven of the parameters (mean, skewness, 1st percentile, 10th percentile, 50th percentile, 90th percentile, and 99th percentile) were statistically significant (P &lt; 0.05). In the ADC histogram, the differences between the two groups in three of the parameters (skewness, 10th percentile, and 50th percentile) were statistically significant (P &lt; 0.05). In the T1CE histogram, no significant differences were found between the two groups in any of the parameters (all P &gt; 0.05). Of the nine parameters, the 50th percentile was found to have the best diagnostic efficacy. In the T2WI histogram, ROC curve analysis of the 50th percentile yielded the best area under the ROC curve (AUC; 0.742), sensitivity of 70%, and specificity of 83.3%. In the ADC histogram, ROC curve analysis of the 50th percentile yielded the best area under the ROC curve (AUC; 0.783), sensitivity of 81%, and specificity of 76.9%.Conclusion: The parameters of the mean, 10th percentile and 50th percentile in the T2WI histogram have good diagnostic efficacy, providing new methods and ideas for clinical diagnosis.
Evaluación de la autoeficacia de emprendimiento y las capacidades de innovación en emprendedores del servicio turístico
Authors: Carranza Quimi Wendy Diana , Carranza Quimi Evelyn Janina , Manosalvas Vaca Luis Oswaldo 
Published: September 2021

La investigación analiza el comportamiento emprendedor e innovador de los prestadores de servicios del sector turístico, utilizando como estudio de caso el Cantón Baños de Agua Santa, ubicado en la Provincia de Tungurahua. Se plantearon objetivos que van direccionados a diagnosticar, caracterizar y determinar la situación actual de los emprendedores y su influencia en el entorno que se desempeñan, de la misma manera, identificar si existe una relación entre la autoeficacia emprendedora y las capacidades de innovación. La metodología utilizada tiene un enfoque cuantitativo mediante el uso de instrumentos de medición validados y confiables para evaluar la autoeficacia emprendedora y las capacidades de innovación; el diseño de la investigación fue no experimental, con un horizonte transversal, de campo y documental con un análisis descriptivo y correlacional. Los resultados indicaron un perfil demográfico masculino predominante, con una edad joven adulta, y educación máxima alcanzada de bachillerato, la mayoría de estos emprendimientos pertenecen a servicios de alimentos y bebidas, seguido de alojamiento turístico, en donde no se identifica influencia recibida por familiares, también se demostró que los emprendedores no tienen un nivel adecuado de autoeficacia emprendedora y capacidad innovadora lo que limita el desarrollo de la actividad de emprendimiento, sin embargo, las relaciones desarrolladas por las redes con los miembros de la comunidad y la intención de innovar es fuerte al igual que el afrontar cambios inesperados del entorno. Existe una correlación positiva y significativa entre la autoeficacia emprendedora y las capacidades de innovación.
La universidad cubana del siglo XXI: la Sede Universitaria Municipal
Authors: Martín Blanco José Arsenio 
Published: September 2021

La educación cubana ha sostenido un importante desarrollo a raíz de la campaña de alfabetización desarrollada en el año 1961, en que la luz del saber llegó hasta los más apartados rincones de la isla, comienza así un proceso de desarrollo en espiral que tiene su parangón actual en las Sedes Universitarias Municipales.
En el presente trabajo abordamos el surgimiento de las Sedes Universitarias Municipales (SUM). Su implantación y desarrollo a lo largo y ancho de la geografía nacional. El rol que desempeñan en el contexto municipal como prolongación de la universidad, y como gestores del conocimiento local.
A importância da parceria entre família e escola no desenvolvimento educacional
Authors: De Sousa Ana Paula 
Published: September 2021

A família é o primeiro contexto na qual a criança desenvolve padrões de socialização, deste modo, ela se relaciona com todo o conhecimento adquirido durante sua experiência de vida primária que vai refletir na sua vida escolar. Sendo assim, o sucesso da tarefa da escola depende da colaboração familiar ativa.
É impossível colocar à parte escola, família e sociedade, pois, se o indivíduo é aluno, filho e cidadão, ao mesmo tempo, a tarefa de ensinar não compete apenas à escola, porque o aluno aprende também através da família, dos amigos, das pessoas que ele considera significativas, dos meios de comunicação, do cotidiano. Sendo assim, é preciso que professores, família e comunidade tenham claro que a escola precisa contar com o envolvimento de todos.
É necessário que família e escola se encarem responsavelmente como parceiras de caminhada, pois, ambas são responsáveis pelo que produz, podendo reforçar ou contrariar a influência uma da outra. Família e escola precisam criar, através da educação, uma força para superar as suas dificuldades, construindo uma identidade própria e coletiva, atuando juntas como agentes facilitadores do desenvolvimento pleno do educando.
ASCITIS PANCREÁTICA TRAUMÁTICA. MANEJO CONSERVADOR: REPORTE DE UN CASO
Authors: GUERRERO MACIAS SILVIA INES , BUSTOS GUERRERO ADA MERCEDES , CASTANEDA ALFONSO SERGIO ANDRES , JAIMES SANABRIA MAYRA ZULAY 
Published: September 2021

Objetivo: presentar el caso de un paciente masculino adulto joven, con ascitis pancreática secundaria a lesión del conducto pancreático por trauma abdominal cerrado, tratado con éxito con terapia conservadoraMaterial y método: datos e imágenes recopilados de la historia clínica del Hospital Universitario de Santander, previo consentimiento informadoResultado: masculino de 21 años con antecedente de trauma abdominal cerrado, quien consulta por distensión, dolor abdominal progresivo y pérdida de peso no cuantificada. Ante sospecha de lesión de conducto pancreático se solicitó pancreatografía por resonancia magnética que evidencia una alteración del segmento proximal del conducto pancreático principal asociado a lesión quística en el borde anterior de la unión de la cabeza con el cuerpo pancreático. Se decidió manejo conservador por 4 semanas con colocación de dren abdominal, reposo intestinal, asociado a nutrición parenteral total y análogos de somatostatina.Discusión: un 5% del trauma abdominal cerrado puede provocar pancreatitis y fugas en el conducto pancreático. Conclusión: la lesión del conducto pancreático principal debe sospecharse en todos los pacientes con trauma abdominal cerrado. El manejo debe realizarse con una planificación cuidadosa y exhaustiva.
LIPOINYECCION MAMARIA CON FINES ESTETICOS: RESULTADOS A LARGO PLAZO CON UNA SESION (BREAST LIPOINJECTION FOR AESTHETIC PURPOSES: LONG-TERM RESULTS WITH ONE SESSION)
Authors: Andrades Cvitanic Patricio , Maripangui Maritza Pilar , Navia Torelli Alfonso 
Published: September 2021

Antecedentes: Aumento mamario con lipoinjerto ha aumentado debido a que evita usar protesis. Es utilizado para aumentos moderados con fines estéticos, no retarda el diagnóstico de cancer ni aumenta el riesgo de sufrirlo. Objetivo: Revisar nuestra experiencia en aumento mamario estético con lipoinjerto, en una sesión y con seguimiento superior a un año. Metodos: Se diseñó una cohorte prospectiva de mujeres. Se excluyeron aquellas con alteraciones congénitas, mesenquimopatías y fumadoras. La lipoinyección se efectuó con principios de Coleman. Para la medición del volumen mamario preoperatorio se utilizó la aplicación Breast-V. Volumen de aumento, tasa de retención y tasa de aumento fueron calculados. Resultados: 73 pacientes fueron lipoinjertadas. Volumen mamario inicial fue 219,5 ± 44,1 cc. Volumen de aumento fue 99,9 ± 29,8 cc, tasa de retención grasa injertada 41.4% y tasa de aumento del volumen mamario 48.1%. 41 pacientes presentaron imágenes postoperatorias: quistes 15 pacientes (36,6%);necrosis grasa 2 pacientes (4,9%); macrocalcifiaciones 8 pacientes (19,5%) y microcalcifiaciones 1 paciente (2,5%), cuya biopsia por punción fue negativa para malignidad. Discusión: El lipoinjerto mamario es un procedimiento seguro, con resultados adecuados cuando se realiza en una sesión y por el mismo cirujano, siguiendo principios de Coleman. El aumento porcentual es el índice más significativo para evaluar su éxito. Conclusiones: Lipoinyección mamaria en una sesión es una técnica segura. Es útil para pequeños y moderados aumentos o corrección de asimetrías leves. No hay evidencia de que interfiera con el diagnóstico precoz del cancer de mama.
ECONOMIC STUDY TO MEASURE THE EFFICIENCY AND ITEMS OF MARKETING MARGINS OF TOMATO CROP YEAR 2015 AL-TAJI DISTRICT
Authors: Jassam Q. T. 
Published: September 2021

The aim of this study is to calculate the marketing efficiency to measures range of efficiency of the marketing processes of crop and their satisfaction of consumer demand, and calculate the marketing margin in marketing process for stage producer – whole sale and whole sale- retailer stage, and to fulfillment the requirements the research it is aims . The data was collected from 32 farms of tomato from AL-Taji District_Baghdad province Agricultural season 2015 non covered agriculture. The marketing efficiency of sample low 32. 5, and the absolute marketing margin in stage of wholesaler-retailer was 230 I.d/kg, and retailers importance it was 39.36%, although that relative importance of the retailer profits from the marketing margin about 67.59%,the study recommended to increasing the efficiency the marketing processes to increase the marketing efficiency ad reducing the waste during the marketing processes, and to cultured the farmers about necessity of the marketing processes in side the farm.
INFLUENC OF IRRIGATION PERIODS AND ORGANIC FERTILIZER ON TOW RICE VSRIETIES GROWN UNDER THE RSYSTEM OF RICE INTENSIFICATION (SRI)
Authors: & Al-Maadhedi Al-Hasanie , & Al-Maadhedi Al-Hasanie 
Published: September 2021

A field trial was conducted at Al-Mishkhab Rice Research Station at Najaf Governorate during 2015 season to assess the effects of irrigation periods and organic manure on yield and its components of two local rice varieties (Anber 33, Jasmine) under System of Rice Intensification (SRI). The experiment was conducted using split split plot arrangement with RCBD design with three replicates. The main plots were irrigation methods where practiced: continuous submerge and intermittent water application where irrigation water was scheduled at two different intervals 3, 5 days. The sub plots were varieties (anber33,jasmin) and three amount of organic manures 0, 5, 10 ton.haˉ¹, planted under System of Rice Intensification (SRI) compared with conventional method (farmer practice). Transplanted method was done when (SRI) implemented and seedlings were transplanted by pattern square 25×25cm between other with one seedlings per hill and early transplanted 15 days seedling old. The conventional method were closed randomize space (10- 15)cm with more than one (3-5) seedlings, and late transplanted (30 days) seedling old. The results indicated that can be save amount of water and obtain of high yield by 29.5% with less water consumption by 57.6 % was used irrigation intervals of 3 days compared with continuance submerge, and then the amount of water consumption with 3 days interval was 3.67 mm equal 36.762 m³.haˉ¹, with 5 days interval 3.18 mm equal 31.869 m³.haˉ¹, with continuance submerge 8.66 mm equal 86.678 m³.haˉ¹. Also the results indicated that the water use efficiency (WUE) with irrigation interval 5 days was 31869 kg m-³ , with 3 days interval was 36762kg m-³ , with continuous submerge was 86678 kg m-³. The WUE Increase was with 3 days interval 70 %, and then the water consumption was reduced 2.2 compared with continuous submerge. The results indicated that there were significant differences with growth parameters (plant hight, and dry matter weight) and significant differences with yield and its components (Panicle number per m², grain number per panicle, 1000 grain weight, sterile percent, grain yield, and harvest index) when used 3 days intervals and 10 ton.haˉ¹ organic manure.