bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Cr(VI) adsorption on glutaraldehyde crosslinked chitosan beads using cyclic voltammetry employing gold electrode
Authors: Watwe Varuna , Kulkarni Preeti 
Published: August 2021

AbstractHexavalent chromium is one of the toxic heavy metals found in wastewaters from industries like electroplating, leather tanning, and steel manufacturing. The Cr(VI) removal and quantitative detection are among the major concerns from an environmental toxicity point of view. In the present work, we report an effective electrochemical technique for Cr(VI) monitoring based on the utilization of gold electrode. The technique developed is user-friendly, non-destructive, and provides real-time monitoring of Cr(VI) from wastewaters in contrast to other spectroscopic and optical techniques. The technique developed was applied in monitoring Cr(VI) removal from synthetic Cr(VI) samples using chitosan cross-linked glutaraldehyde (C + G) beads. The parameter optimization for Cr(VI) removal using C + G beads was done. The experimental data of Cr(VI) adsorption on C + G beads obtained using cyclic voltammetry were further used for kinetic and thermodynamic studies. Kinetic and thermodynamic studies found that Cr(VI) adsorption follows pseudo-second-order kinetics and Modified Langmuir isotherm. The maximum adsorption capacity of C + G beads for Cr(VI) was found to be 28.65 mg g−1. These results obtained indicate that the cyclic voltammetric technique using gold electrode can be effectively applied for Cr(VI) analysis from wastewaters.
Progression of pelvic retroversion is a critical factor for clinical outcome after Opening-wedge high tibial osteotomy among elderly patients
Authors: Otsuki Shuhei , Wakama Hitoshi , Ikeda Kuniaki , Okuno Nobuhiro , Okamoto Yoshinori , Okayoshi Tomohiro , Matsuyama Junya , Neo Masashi 
Published: August 2021

AbstractPurposeTo evaluate the clinical outcome after opening-wedge high tibial osteotomy (OWHTO) and to determine the critical factors for a poor clinical outcome after OWHTO in patients aged over 65 years.MethodsOur retrospective analysis was based on the data from 233 patients who underwent OWHTO for medial compartment knee OA at our institution between January 2013 and December 2018, and 88 patients (36 men and 52 women) over 65 years of age were included in this study. Radiographic parameters of weight-bearing line ratio (WBLR) and pelvic inclination (PI); the knee function, range of motion (ROM) and extension; and clinical outcome with Lysholm score were obtained preoperatively and postoperatively at the final follow-up visit. To evaluate the critical factors for the clinical outcome, univariate regression analysis was used to identify the relationship between postoperative and improved Lysholm score and pre-and post-operative essential factors. To reveal the factor having a greater impact on the clinical outcome, ap < 0.05 in univariate factors was entered into a multivariate regression analysis.ResultsThe preoperative WBLR was significantly changed, and Lysholm score improved from 59.5 to 81.5 (p < 0.0001), whereas the PI, knee extension and ROM were not changed after OWHTO. Regarding the essential factors affecting clinical outcome after OWHTO, age and delta PI were negative, whereas preoperative WBLR, postoperative ROM, especially extension, had a positive effect (p < 0.05). Furthermore, only delta PI had affected the improvement of clinical outcome with OWHTO (p < 0.01), and postoperative knee extension was negatively correlated with the progression of pelvic retroversion (p < 0.01).ConclusionAge at surgery and progression of pelvic retroversion were the critical factors for poor postoperative clinical outcomes after OWHTO. Care should be taken for the progression of pelvic retroversion after OWHTO because it deteriorates the clinical outcome by inducing the knee flexion contracture as the compensatory mechanism for the balance of sagittal alignment.
Cutaneous metastasis of cecum cancer with MSI-high and BRAFV600E mutation: a case report
Authors: Yunoki Kosuke , Yano Takuya , Yoshimitsu Masanori , Oshita Ko , Kubota Tetsushi , Ishida Michihiro , Satoh Daisuke , Choda Yasuhiro , Nakano Kanyu , Shirakawa Yasuhiro , Matsukawa Hiroyoshi , Idani Hitoshi , Shiozaki Shigehiro , Okajima Masazumi 
Published: August 2021

Abstract
Background
Cutaneous metastases of colorectal cancer (CRC) are rare, occurring in 0.7% to 5% of cancer patients. Furthermore, the molecular subtypes of cutaneous metastasis of CRC are unclear. Here, we present a rare case of cutaneous metastasis of high-frequency microsatellite instability (MSI-high)/BRAFV600E-mutant cecum cancer.

Case presentation
A 77-year-old woman presented at the outpatient clinic with a subcutaneous mass on her left back. An excisional biopsy was performed and metastatic cutaneous adenocarcinoma was diagnosed. A computed tomography scan of the thorax and abdomen showed thickening of the cecum wall, the presence of pericolic lymph nodes, multiple masses in the liver, and a single nodule in the right lung. Right colectomy with D2 lymphadenectomy and functional end-to-end anastomosis was performed because of the almost-complete intestinal obstruction. The expression of KRAS wild type, BRAFV600E mutation, and MSI-high was detected in the cecum cancer using molecular pathological examination. She received chemotherapy with XELOX + BEV regimen (capecitabine + oxaliplatin + bevacizumab). After four administrations, a computed tomography scan showed reduction of distant metastases, which suggested partial response.

Conclusions
We encountered a rare case of cutaneous metastasis of MSI-high and BRAFV600E-mutant cecum cancer. In the future, it will be necessary to accumulate more cases to identify clinical features and more effective treatments for CRCs with cutaneous metastasis.
Intraocular lens power calculation formulas accuracy in combined phacovitrectomy: an 8-formulas comparison study
Authors: Hipólito-Fernandes Diogo , Elisa Luís Maria , Maleita Diogo , Gil Pedro , Maduro Vitor , Costa Lívio , Marques Nuno , Branco João , Alves Nuno 
Published: August 2021

Abstract
Background
Our study aimed to assess and compare the accuracy of 8 intraocular lens (IOL) power calculation formulas (Barrett Universal II, EVO 2.0, Haigis, Hoffer Q, Holladay 1, Kane and PEARL-DGS) in patients submitted to combined phacovitrectomy for vitreomacular (VM) interface disorders.

Methods
Retrospective chart review study including axial-length matched patients submitted to phacoemulsification alone (Group 1) and combined phacovitrectomy (Group 2). Using optimized constants in both groups, refraction prediction error of each formula was calculated for each eye. The optimised constants from Group 1 were also applied to patients of Group 2 – Group 3. Outcome measures included the mean prediction error (ME) and its standard deviation (SD), mean (MAE) and median (MedAE) absolute errors, in diopters (D), and the percentage of eyes within ± 0.25D, ± 0.50D and ± 1.00D.

Results
A total of 220 eyes were included (Group 1: 100; Group 2: 120). In Group 1, the difference in formulas absolute error was significative (p = 0.005). The Kane Formula had the lowest MAE (0.306) and MedAE (0.264). In Group 2, Kane had the overall best performance, followed by PEARL-DGS, EVO 2.0 and Barrett Universal II. The ME of all formulas in both Groups 1 and 2 were 0.000 (p = 0.934; p = 0.971, respectively). In Group 3, a statistically significant myopic shift was observed for each formula (p < 0.001).

Conclusion
Surgeons must be careful regarding IOL power selection in phacovitrectomy considering the systematic myopic shift evidenced—constant optimization may help eliminating such error. Moreover, newly introduced formulas and calculation methods may help us achieving increasingly better refractive outcomes both in cataract surgery alone and phacovitrectomy.
High dose letrozole in infertile women with unilateral tubal block: a preliminary report
Authors: Al-Hussaini Tarek K. 
Published: August 2021

Abstract
Background
Till now, there is no universal agreement on the best management of women with unilateral blocked tube. The aim of this study was to evaluate the use of high dose letrozole in infertile women with one blocked tube. This prospective non-randomized study was conducted at a university-affiliated infertility unit. It included 15 women with one blocked tube (proximal or mid segmental block) with a period of 1–6 years of infertility. Letrozole (10 mg/day for 5 days) was prescribed for all of them for a maximum of three cycles. The primary outcome was Live birth rate.

Results
Nine out of the 15 women conceived (60%). Live birth rate was 53% (8/15). All women had a good response to this regimen. None complained of side effects of this dose. No multiple pregnancies and/or congenital anomalies were reported.

Conclusions
This preliminary report showed that treatment of infertile women, with unilateral tubal block, with high dose letrozole is effective. To our knowledge, this is the first report in the English literature on the use of high dose of letrozole in such cases.
Patient-Reported Outcomes Integrated Within an Electronic Medical Record in Patients With Head and Neck Cancer
Authors: Ossowski Stephanie , Kammerer Amy , Stram Douglas , Piazza-DeLap Lisa , Basch Ethan , Katzel Jed A. 
Published: August 2021

PURPOSE Patient-reported outcome (PRO) tools lead to clinical benefits, including improved overall survival for patients with cancer. However, routine implementation of PROs in clinical practice within the electronic medical record (EMR) by integrated health care delivery systems remains limited. We studied the use of a PRO tool for patients with head and neck cancer (HNC) integrated in an EMR at Kaiser Permanente in Northern California. METHODS Between August 2017 and December 2019, patients with newly diagnosed HNC were surveyed at baseline, then every 3 months using the Functional Assessment of Cancer Therapy–General 7 and Functional Assessment of Cancer Therapy–Head and Neck (version 4). A medical assistant performed a baseline survey on diagnosis and then notified patients electronically per surveillance protocol. Patients who did not respond to online PRO surveys could complete them via telephone or in-person appointments with medical assistants. Abnormal findings on PRO surveys were referred to appropriate members of the care team or the treating Otolaryngology-Head and Neck Surgery physicians. RESULTS Two hundred ninety patients received baseline surveys. Patients received up to a maximum of eight subsequent surveys. Of a total of 597 electronic surveys, 585 (97.9%) were completed. The percentage of patients completing each interval survey ranged from 92% to 100%. Multivariate Poisson regression analysis showed patients with English as their primary language and an online secure account were the most likely to complete surveys compared with those patients with non-English as a primary language and without an online account. CONCLUSION PRO tools can be effectively used within the EMR for patients with HNC with a high response rate provided there is strong engagement from a dedicated member of the care team. This has important implications for designing clinical trials and symptom monitoring in clinical practices that incorporate EMRs.
Teleoncology for Veterans: High Patient Satisfaction Coupled With Positive Financial and Environmental Impacts
Authors: Jiang Cindy Y. , Strohbehn Garth W. , Dedinsky Rachel M. , Raupp Shelby M. , Pannecouk Brittany M. , Yentz Sarah E. , Ramnath Nithya 
Published: August 2021

PURPOSE: There was rapid adoption of teleoncology care in the Veterans Health Administration during the COVID-19 pandemic. One third of 9 million Veterans Health Administration enrolled Veterans live in rural areas. Although digital solutions can expand capacity, enhance care access, and reduce financial burden, they may also exacerbate rural-urban health disparities. Careful evaluation of patients' perceptions and policy tradeoffs are necessary to optimize teleoncology postpandemic. METHODS: Patients with ≥ 1 teleoncology visit with medical, surgical, or radiation oncology between March 2020 and June 2020 were identified retrospectively. Validated, Likert-type survey assessing patient satisfaction was developed. Follow-up survey was conducted on patients with ≥ 1 teleoncology visit from August 2020 to January 2021. Travel distance, time, cost, and carbon dioxide emissions were calculated based on zip codes. RESULTS: A hundred surveys were completed (response rate, 62%). Patients overall were satisfied with teleoncology (83% Agree or Strongly Agree) but felt less satisfied than in-person visits (47% Agree or Strongly Agree). Audiovisual component improved patient perception of involvement in care, ability to self-manage health or medical needs, and comparability to in-person visits. Follow-up survey demonstrated similar satisfaction. Total travel-related savings are as follows: 86,470 miles, 84,374 minutes, $49,720 US dollars, and 35.5 metric tons of carbon dioxide. CONCLUSION: Veterans are broadly satisfied with teleoncology. Audiovisual capabilities are critical to satisfaction. This is challenging for rural populations with lack of technology access. Patients experienced financial and time savings, and society benefitted from reduced carbon emissions. Continued optimization is needed to enhance patient experience and address secondary effects.
Effect of 6% Hydroxyethyl Starch 130/0.4 on Inflammatory Response and Pulmonary Function in Patients Having Cardiac Surgery: A Randomized Clinical Trial
Authors: Lee Mee Jee , Tannenbaum Charles , Mao Guangmei , Jia Yuan , Leung Steve , Yilmaz Hüseyin Oğuz , Ince Ilker , Soltesz Edward , Duncan Andra E. 
Published: August 2021

BACKGROUND:
Cardiac surgery with cardiopulmonary bypass induces a profound inflammatory response that, when severe, can lead to multiorgan system dysfunction. Preliminary data suggest that administration of hydroxyethyl starch (HES) solutions may mitigate an inflammatory response and improve pulmonary function. Our goal was to examine the effect of 6% HES 130/0.4 versus 5% human albumin given for intravascular plasma volume replacement on the perioperative inflammatory response and pulmonary function in patients undergoing cardiac surgery.

METHODS:
This was a subinvestigation of a blinded, parallel-group, randomized clinical trial of patients undergoing elective aortic valve replacement surgery at the Cleveland Clinic main campus, titled “Effect of 6% Hydroxyethyl Starch 130/0.4 on Kidney and Haemostatic Function in Cardiac Surgical Patients.” Of 141 patients who were randomized to receive either 6% HES 130/0.4 or 5% human albumin for intraoperative plasma volume replacement, 135 patients were included in the data analysis (HES n = 66, albumin n = 69). We assessed the cardiopulmonary bypass–induced inflammatory response end points by comparing the 2 groups’ serum concentrations of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and macrophage migration inhibitory factor (MIF), measured at baseline and at 1 and 24 hours after surgery. We also compared the 2 groups’ postoperative pulmonary function end points, including the ratio of partial pressure of arterial oxygen to fraction of inspired oxygen (Pao
2:Fio
2 ratio), dynamic lung compliance, oxygenation index (OI), and ventilation index (VI) at baseline, within 1 hour of arrival to the intensive care unit, and before tracheal extubation. The differences in the postoperative levels of inflammatory response and pulmonary function between the HES and albumin groups were assessed individually in linear mixed models.

RESULTS:
Serum concentrations of the inflammatory markers (TNF-α, IL-6, MIF) were not significantly different (P ≥ .05) between patients who received 6% HES 130/0.4 or 5% albumin, and there was no significant heterogeneity of the estimated treatment effect over time (P ≥ .15). The results of pulmonary function parameters (Pao
2:Fio
2 ratio, dynamic compliance, OI, VI) were not significantly different (P ≥ .05) between groups, and there was no significant heterogeneity of the estimated treatment effect over time (P ≥ .15).

CONCLUSIONS:
Our investigation found no significant difference in the concentrations of inflammatory markers and measures of pulmonary function between cardiac surgical patients who received 6% HES 130/0.4 versus 5% albumin.
The National Heart, Lung, and Blood Institute data: analyzing published articles that used BioLINCC open access data
Authors: AlRyalat Saif Aldeen , El Khatib Osama , Al-qawasmi Ola , Alkasrawi Hadeel , al Zu’bi Raneem , Abu-Halaweh Maram , alkanash Yara , Habash Ibrahim 
Published: August 2021

Background: Data sharing is now a mandatory prerequisite for several major funders and journals, where researchers are obligated to deposit the data resulting from their studies in an openly accessible repository. Biomedical open data are now widely available in almost all disciplines, where researchers can freely access and reuse these data in new studies. We aim to study the BioLINCC datasets, number of publications that used BioLINCC open access data, and the citations received by these publications. Methods: As of July 2019, there was a total of 194 datasets stored in BioLINCC repository and accessible through their portal. We requested the full list of publications that used these datasets from BioLINCC, and we also performed a supplementary PubMed search for other publications. We used Web of Science (WoS) to analyze the characteristics of publications and the citations they received, where WoS database index high quality articles. Results: 1,086 published articles used data from BioLINCC repository for 79 (40.72%) datasets, where 115 (59.28%) datasets did not have any publications associated with it. Of the total publications, 987 (90.88%) articles were WoS indexed. The number of publications has steadily increased since 2002 and peaked in 2018 with a total number of 138 publications on that year. The 987 open data publications (i.e., secondary publications) received a total of 34,181 citations up to 1 st October 2019. The average citation per item for the open data publications was 34.63. The total number of citations received by open data publications per year has increased from only 2 citations in 2002, peaking in 2018 with 2361 citations. Conclusion: Majority of BioLINCC datasets were not used in secondary publications. Despite that, the datasets used for secondary publications yielded publications in WoS indexed journals and are receiving an increasing number of citations.
Studi Perencanaan Usaha Keripik Kaca Menggunakan Business Model Canvas
Authors: Maulida Ayuni Rizma , Haryanto Andre Geza 
Published: August 2021

The business world needs a business plan that can help entrepreneurs prepare everything needed for the smooth running of their business. This business plan can be made in the form of a business plan. One business plan model that has many advantages is the Business Model Canvas. The purpose of writing this article is to find out what needs to be considered in making a business plan using the Business Model Canvas. The results of the literature review show that using the Business Model Canvas business planning becomes clearer and more focused. The glass chip business, which is an example in the application of the canvas business model, is becoming more focused and clear. Therefore, in making a business model, the canvas has 9 important components, including Customer Segment, Value Propositions, Channels, Customer Relationships, Revenue Streams, Key Activities, Key Partnerships, Key Resources and Cost Structures that need to be considered and structured clearly to help run the business.Keywords: business, Business Model Canvas, business plan, glass chips, planningABSTRAK Dunia usaha memerlukan suatu perencanaan usaha yang dapat membantu wirausahawan menyiapkan segala sesuatu yang dibutuhkan untuk kelancaran usahanya. Perencanaan usaha ini dapat dibuat dalam bentuk business plan. Salah satu model business plan yang banyak memiliki keuntungan yaitu Business Model Canvas. Tujuan dari penulisan artikel ini adalah untuk mengetahui apa saja yang perlu diperhatikan untuk membuat perencanaan usaha menggunakan Business Model Canvas. Hasil dari penelaahan pustaka menunjukkan dengan menggunakan Business Model Canvas perencanaan usaha menjadi lebih jelas dan terarah. Usaha keripik kaca yang menjadi contoh dalam penerapan Business Model Canvas ini menjadi lebih terarah dan jelas. Oleh karena itu dalam pembuatan Business Model Canvas memiliki 9 komponen penting diantaranya Customer Segment, Value Propositions, Channel, Customer Relationship, Revenue Streams, Key Activities, Key Partnership, Key Resources dan Cost Structure yang perlu diperhatikan dan disusun dengan jelas agar membantu kelancaran usaha. Kata Kunci: Business Model Canvas, business plan, keripik kaca, perencanaan, usaha
Efficient four-wave mixing based on multiple plasmonic resonance
Authors: Wang Junying , Lv Bokun , Liu Dahe , Gong Wenping , Shi Jinwei 
Published: August 2021

Plasmonic nanostructures provide a new way to improve nonlinear optical effects. As a mode of surface plasmons (SP), localized SPs can highly localize and enhance electromagnetic fields within a subwavelength volume. In this work, we developed a one-dimensional V-groove Ag nanograting. Through simulation, we realized triple-resonance enhanced four-wave mixing (FWM), in which both the excitation and signal waves are in resonance with LSPRs modified by propagating SPs, and can perfectly overlap with each other in each single nanogroove. Compared with that from a flat Ag plate, the FWM enhancement factor can be over six orders of magnitude. Next, we filled the Ag V-groove with nonlinear polymer 2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene and further improved the enhancement factor to eight orders of magnitude, together with a conversion efficiency of

1.02

×

10

−
2

. Finally, by changing the water filling ratio, the FWM signal is tuned over 180 nm, while keeping the enhancement factor over seven orders of magnitude.