bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Chest Radiographic Thoracic Area Can Serve as a Prediction Marker for Morbidity and Mortality in Infants With Congenital Diaphragmatic Hernia
Authors: Weis Meike , Burhany Sosan , Perez Ortiz Alba , Nowak Oliver , Hetjens Svetlana , Zahn Katrin , Schoenberg Stefan , Schaible Thomas , Rafat Neysan 
Published: December 2021

Objective: Valid postnatal prediction parameters for neonates with congenital diaphragmatic hernia (CDH) are lacking, but recently, the chest radiographic thoracic area (CRTA) was proposed to predict survival with high sensitivity. Here, we evaluated whether the CRTA correlated with morbidity and mortality in neonates with CDH and was able to predict these with higher sensitivity and specificity than prenatal observed-to-expected (O/E) lung-to-head ratio (LHR).Methods: In this retrospective cohort study, all neonates with CDH admitted to our institution between 2013 and 2019 were included. The CRTA was measured using the software Horos (V. 3.3.5) and compared with O/E LHR diagnosed by fetal ultrasonography in relation to outcome parameters including survival, extracorporeal membrane oxygenation (ECMO) support, and chronic lung disease (CLD).Results: In this study 255 neonates were included with a survival to discharge of 84%, ECMO support in 46%, and 56% developing a CLD. Multiple regression analysis demonstrated that the CRTA correlates significantly with survival (p = 0.001), ECMO support (p &lt; 0.0001), and development of CLD (p = 0.0193). The CRTA displayed a higher prognostic validity for survival [area under the curve (AUC) = 0.822], ECMO support (AUC = 0.802), and developing a CLD (AUC = 0.855) compared with the O/E LHR.Conclusions: Our data suggest that the postnatal CRTA might be a better prognostic parameter for morbidity and mortality than the prenatal O/E LHR.
Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19
Authors: Zheng Wenjiang , Wang Ting , Wu Peng , Yan Qian , Liu Chengxin , Wu Hui , Zhan Shaofeng , Liu Xiaohong , Jiang Yong , Zhuang Hongfa 
Published: December 2021

Background: The COVID-19 pandemic poses an imminent threat to humanity, especially for those who have comorbidities. Evidence of COVID-19 and COPD comorbidities is accumulating. However, data revealing the molecular mechanism of COVID-19 and COPD comorbid diseases is limited.Methods: We got COVID-19/COPD -related genes from different databases by restricted screening conditions (top500), respectively, and then supplemented with COVID-19/COPD-associated genes (FDR&lt;0.05, |LogFC|≥1) from clinical sample data sets. By taking the intersection, 42 co-morbid host factors for COVID-19 and COPD were finally obtained. On the basis of shared host factors, we conducted a series of bioinformatics analysis, including protein-protein interaction analysis, gene ontology and pathway enrichment analysis, transcription factor-gene interaction network analysis, gene-microRNA co-regulatory network analysis, tissue-specific enrichment analysis and candidate drug prediction.Results: We revealed the comorbidity mechanism of COVID-19 and COPD from the perspective of host factor interaction, obtained the top ten gene and 3 modules with different biological functions. Furthermore, we have obtained the signaling pathways and concluded that dexamethasone, estradiol, progesterone, and nitric oxide shows effective interventions.Conclusion: This study revealed host factor interaction networks for COVID-19 and COPD, which could confirm the potential drugs for treating the comorbidity, ultimately, enhancing the management of the respiratory disease.
Prospective Study of Serum Uric Acid Levels and First Stroke Events in Chinese Adults With Hypertension
Authors: Hu Feng , Hu Longlong , Yu Rihua , Han Fengyu , Zhou Wei , Wang Tao , Zhu Linjuan , Huang Xiao , Bao Huihui , Cheng Xiaoshu 
Published: December 2021

Objectives: We investigated the association between serum uric acid (SUA) levels and the risk of the first stroke in Chinese adults with hypertension.Methods: A total of 11, 841 hypertensive patients were selected from the Chinese Hypertension Registry for analysis. The relationship between SUA levels and first stroke was determined using multivariable Cox proportional hazards regression, smoothing curve fitting, and Kaplan–Meier survival curve analysis.Results: During a median follow-up of 614 days, 99 cases of the first stroke were occurred. Cox proportional hazards models indicated that SUA levels were not significantly associated with the first stroke event [adjusted-hazard ratio (HR) per SD increase: 0.98, 95% CI 0.76–1.26, P = 0.889]. In comparison to the group without hyperuricemia (HUA), there were no significantly higher risks of first stroke events (adjusted-HR: 1.22, 95% CI 0.79–1.90, P = 0.373) in the population with HUA. However, in the population less than 60 years old, subjects with HUA had a significantly higher risk of the first stroke than the population without HUA (adjusted-HR: 4.89, 95% CI 1.36–17.63, P = 0.015). In subjects older than 60 years, we did not find a significant relationship between HUA and first stroke (adjusted-HR: 0.97, 95% CI 0.60–1.56, P = 0.886). Survival analysis further confirmed this discrepancy (log-rank P = 0.013 or 0.899 for non-aging or aging group).Conclusion: No significant evidence in the present study indicated that increased SUA levels were associated with the risk of first stroke in the Chinese adults with hypertension. Age played an interactive role in the relationship between HUA and the first stroke event.
The Impact of COVID-19 on Sleep Quality in People Living With Disabilities
Authors: Heinze Nikki , Hussain Syeda F. , Castle Claire L. , Godier-McBard Lauren R. , Kempapidis Theofilos , Ftouni Suzanne , Espie Colin A. , Gomes Renata S. M. 
Published: December 2021

Background: Research exploring the impact of the COVID-19 pandemic on sleep in people with disabilities has been scarce. This study provides a preliminary assessment of sleep in people with disabilities, across two timepoints during the pandemic, with a focus on those with visual impairment (VI).Methods: Two online surveys were conducted between April 2020 and March 2021 to explore sleep quality using the Pittsburgh Sleep Quality Index (PSQI). A convenience sample of 602 participants completed the first survey and 160 completed the follow-up survey.Results: Across both timepoints, participants with disabilities reported significantly poorer global sleep quality and higher levels of sleep disturbance, use of sleep medication and daytime dysfunction than those with no disabilities. Participants with VI reported significantly higher levels of sleep disturbance and use of sleep medication at both timepoints, poorer global sleep quality, sleep duration and latency at time 1, and daytime dysfunction at time 2, than those with no disabilities. Global sleep quality, sleep duration, sleep efficiency, and self-rated sleep quality deteriorated significantly in participants with no disabilities, but daytime dysfunction increased in all three groups. Disability and state anxiety were significant predictors of sleep quality across both surveys.Conclusion: While sleep was consistently poorer in people with disabilities such as VI, it appears that the COVID-19 pandemic has had a greater impact on sleep in people with no disabilities. State anxiety and, to a lesser extent, disability, were significant predictors of sleep across both surveys, suggesting the need to address anxiety in interventions targeted toward improving sleep.
Negative Emotions in Chinese Frontline Medical Staff During the Early Stage of the COVID-19 Epidemic: Status, Trend, and Influential Pathways Based on a National Investigation
Authors: Sun Xiaoxiao , Xie Fei , Chen Beijing , Shi Peixia , Shen Sitong , Chen Zhaohua , Yuan Yuan , Zhang Mengjia , Qin Xuemei , Liu Yingzhe , Wang Yuan , Dai Qin 
Published: December 2021

Objective: The outbreak of coronavirus disease 2019 (COVID-19), declared as a major public health emergency, has had profound effects on public mental health especially emotional status. Due to professional requirements, medical staff are at a higher risk of infection, which might induce stronger negative emotions. This study aims to reveal the emotional status of Chinese frontline medical staff in the early epidemic period to better maintain their mental health, and provide adequate psychological support for them.Methods: A national online survey was carried out in China at the early stage of the COVID-19 epidemic. In total, 3025 Chinese frontline medical staff took part in this investigation which utilized a general information questionnaire, the Emotion Regulation Questionnaire (ERQ), and the Berkeley Expressivity Questionnaire (BEQ).Results: At the early stage of COVID-19, anxiety was the most common negative emotion of Chinese medical staff, followed by sadness, fear, and anger, mainly at a mild degree, which declined gradually over time. Nurses had the highest level of negative emotions compared with doctors and other healthcare workers. Women experienced more fear than men, younger and unmarried medical staff had more anxiety and fear compared with elders and married ones. Risk perception and emotional expressivity increased negative emotions, cognitive reappraisal reduced negative emotions, while negative emotions led to more avoidant behavior and more physical health disturbances, in which negative emotions mediated the effect of risk perception on avoidant behavior tendency in the model test.Conclusion: Chinese frontline medical staff experienced a mild level of negative emotions at the early stage of COVID-19, which decreased gradually over time. The findings suggest that during the epidemic, nurses' mental health should be extensively attended to, as well as women, younger, and unmarried medical staff. To better ensure their mental health, reducing risk perception and improving cognitive reappraisal might be important, which are potentially valuable to form targeted psychological interventions and emotional guidance under crisis in the future.
Application of Combined Superficial Femoral Artery Stenting and Deep Femoral Artery Profundoplasty in Chinese Patients With Lower Extremity Artery Disease
Authors: Chi Guoqing , Ding Mingchao 
Published: December 2021

Objective: Lower extremity artery disease (LEAD) increases sharply with age and results in severe burden in individuals and in society. This study aimed to compare the efficiency of simple superficial femoral artery stenting (SFAS) and the hybrid operation, such as combined SFAS and deep femoral artery profundoplasty (DFAP), in the treatment of Chinese patients with LEAD, classified as Rutherford grades 3–5.Methods: There were 200 patients with LEAD classified as Rutherford grades 3–5 included in the simple SFAS group (n = 100) and the combined SFAS and DFAP group (n = 100).Results: All the patients had median age of 71 years, and there were 143 males (71.5%). Not only the increase rate of ankle brachial index (ABI), but also reduction rate of Rutherford grade, were significantly higher after surgery in the combined SFAS and DFAP group than in the simple SFAS group (P &lt; 0.05 for all). The patency rate of patients in the combined SFAS and DFAP group was significantly higher than that of patients in the simple SFAS group during the follow-up (P &lt; 0.05). Proportion of amputation and claudication distance &lt;200 m had no significant difference between the two groups during the 2-year follow-up (P &gt; 0.05 for all).Conclusion: This study demonstrated that, compared with SFAS, combined SFAS and DFAP improved not only the ABI and the Rutherford grade after surgery but also the patency rate during the follow-up in Chinese patients with LEAD. Hybrid operation has significant value in alleviating clinical symptoms after surgery, and, thereby, improving vascular prognosis in Chinese patients.
Delayed Leukoencephalopathy and Foreign Body Reaction After Endovascular Treatment in Patients With Intracranial Aneurysms and Aneurysmal Subarachnoid Hemorrhage—A Systematic Review of the Literature
Authors: Ridwan Sami , Kandyba Jörg Andreas , Schug Anita , Malsagov Elina , Karageorgos Nikolaos , Hans Franz-Josef 
Published: December 2021

Background: Delayed leukoencephalopathy and foreign body reaction are rare complications after endovascular treatment of intracranial aneurysms. However, cases are increasingly being described, given the rising case numbers and complexity.Methods: Clinical presentation, differentials, diagnostics, treatment, and formerly published data were reviewed in light of available cases. A systematic search of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.Results: This article provides an extensive literature review of previously described cases, and discusses the causes and management of this rare and delayed complication by referring to 17 articles on this topic, with a total of 50 cases with sufficient data in the literature. Furthermore, we present the case of a 53-year-old female patient with subarachnoid hemorrhage from a large anterior communicating artery aneurysm with tortuous cervical vessels who was treated with endovascular coiling and has suffered delayed leukoencephalopathy 6 weeks after discharge. Diagnostics, treatment, and clinical course of this rare complication are presented on this case and based on formerly published literature. The patient timely recovered under high dose corticosteroid treatment and follow up MRI showed almost complete remission of the described lesions within 10 days in accordance with previously published data.Conclusion: Foreign body reaction might result in delayed leukoencephalopathy, especially following complex endovascular aneurysm treatment. Early high dose followed by low dose ongoing corticosteroid treatment might result in timely remission.
PSYCHO-EMOTIONAL SAFETY OF A TEACHER IN PROFESSIONAL ACTIVITY
Authors: VAZHENINA I. , KRAVCHENKO I. 
Published: December 2021

On the basis of the environmental approach, important factors of violation of psycho-emotional safety of ZSSO teacher at his workplace are revealed, the reasons for its destruction in the educational environment are considered and ways to adjust these conditions are outlined to protect educators from professional destruction of psycho-emotional sphere.
The authors believe that one of the factors of psycho-emotional deformations of the teacher, his early burnout is incorrectly chosen or interpreted professional role, which becomes an unbearable burden for him. Therefore, in institutions of higher pedagogical education it is necessary to pay attention to this problem in advance, forming a set of ideas about the content and typical manifestations of a professional role, its compliance with individual biopsychological type of teacher and outlining ways of constructive adaptation of future teachers his source of psychological violence.
It is envisaged that further consideration of the problem should be related to the study of opportunities to prevent professional psycho-emotional destruction of future teachers through innovative forms of higher education, which have become widespread in the pandemic.
AESTHETIC EDUCATION IN THE CONTEXT OF PEDAGOGICAL CONGRESSES OF 1862 - 1919
Authors: DIDENKO I. , FILATOVA O. 
Published: December 2021

Current research is a historic and pedagogical study. It uncovers the problem of aesthetic education in the context of such a meaningful phenomenon of the education of the late 19th century and the early 20th century as pedagogical congresses. The study has proved that the issues of the aesthetic education were considered during almost every pedagogical congress from 1862 till 1919. This type of education was recognized as the necessary part of comprehensive and harmonious development of the child’s personality. Under different political conditions aesthetic education was discussed during the pedagogical congresses either as a separate issue or as an element of other types of education: labor, ethical, national and even physical ones. The main methods and means of the aesthetic education considered by the participants of the pedagogical congresses were the following ones: familiarizing with the works of the prominent foreign and national authors, excursions, getting to know the native land, national traditions, creative labor, different forms of recreation and entertainment, art and musical events, taking care of your appearance. For supporting pedagogical councils, the delegates of the congresses suggested to create aesthetic committees and professional councils. To cut the long story short, the participants of the pedagogical congresses were very attentive to the issues of the aesthetic education and considered it as one of the necessary elements of harmonious development of the personality What remained uncovered was the degree of implementation of the solutions and recommendations of the participants of the pedagogical congresses in the educational process of the schools, namely, what ideas were introduced and what left just on the paper.
PRECONDITIONS OF DEVELOPMENT OF LEISURE ACTIVITIES FOR CHILDREN WITH SPECIAL EDUCATION NEEDS IN OUT-OF-SCHOOL EDUCATIONAL INSTITUTIONS (END OF XX – EARLY XXI CENTURIES)
Authors: KOBOBEL A. 
Published: December 2021

The article considers the preconditions that contributed to the development of leisure activities for children with special educational needs in out-of-school educational institutions. The preconditions include: the formation in the public consciousness of the view on the importance of leisure as a sphere of self-realization of the individual; availability of a global international educational policy on positive and constructive approaches to the education of children with special educational needs; availability of historical experience in the development of models for providing education to such children in out-of-school education institutions; the presence of a community of democracies formed in the public consciousness regarding the humanistic paradigm of inclusive education; the influence of the national pedagogical heritage and the existence of an extensive network of out-of-school educational institutions at the time of Ukraine's independence.
The inclusive model is defined as bringing together all participants in the educational process, including the gifted, the disabled, the socially maladapted, children from vulnerable places, children from poverty and destitution, children from national minorities and children from immigrants. It is proved that the inclusive paradigm is not aimed at adapting the individual to social, social, economic relations, but on the contrary to the restructuring of the entire system of mass education to meet the educational needs of children with special educational needs. This innovative approach promotes the development of leisure activities for children with special educational needs in out-of-school education institutions. The author's definition of the term "inclusive extracurricular education" is considered as an innovative paradigm of educational relations, which focuses on humane treatment of children with special educational needs, excludes any discrimination aimed at social inclusion of children in extracurricular educational space and their social communication.
FORMING OF SKILLS OF SAFE PROFESSIONAL ACTIVITY OF FUTURE SPECIALISTS IN THE TOURISM SECTOR
Authors: KONDEL V. 
Published: December 2021

The article analyzes the research of domestic and foreign scientists on the training of highly qualified specialists in the field of tourism. It is proved that the modern development of tourism directly depends on ensuring the safety of tourists and workers in the tourism industry, the level of protection of their lives, health and property. Examples of teaching the discipline "Safety and Security of Tourism" show the process of developing skills of safe professional activities of future professionals in the field of tourism, the ability to properly assess harmful and dangerous factors and take appropriate measures to prevent hazards or reduce their impact on tourists and tourism industry.
The discipline "Safety and Security of Tourism" is aimed at acquiring knowledge and skills of security in the field of tourism for the successful implementation of professional activities in enterprises and institutions of the tourism industry, in public organizations of tourism, to open and run their own business in recreation and tourism.
The purpose of the discipline is to form students' abilities necessary to create and maintain healthy and safe living and working conditions for tourists and workers in the tourism industry, skills to protect against the negative factors of emergencies during tourist trips, the ability to act confidently in various unusual situations.
To solve the set tasks, the discipline "Safety and Security of Tourism" considers various topics on security in the field of tourism, namely, the theoretical foundations of security, legislation, risk factors, safety of tourists in emergencies, occupational safety at tourism enterprises, sanitary and epidemiological safety, insurance and control over the observance of safety rules, safety of tourists on transport, in various types of tourism, in particular, extreme tourism, rules of conduct in foreign travel and survival of tourists in extreme conditions, accidents and diseases, fire safety in the tourism industry.
For high-quality mastering of the discipline the author of the article has developed methodical recommendations for 12 practical classes on the course "Safety and Security of Tourism", the quality of which allows future professionals to gain not only knowledge necessary for mastering disciplines in senior courses, but also to develop skills for safe professional activity in tourism, hotel and restaurant business.
ON THE QUESTION OF ECOLOGIZATION OF THE EDUCATIONAL ENVIRONMENT IN INCLUSIVE INSTITUTIONS
Authors: KONONOVA M. 
Published: December 2021

The article defines the role of pedagogical ecology in the system of educational practice in the conditions of inclusion. The term "inclusion", the concept of "greening", the definition of universal design in education and reasonable adaptation of school space are revealed. Problems and prospects of greening of the educational environment in the context of inclusive education are considered. Comparing the inclusive culture of our country and the Scandinavian countries, it is noted that the approach of Scandinavian cultures is more to ensure inclusiveness, inclusion in society. The conditions for the implementation of the principles of pedagogical ecology in inclusive education are determined.
It is proved that the success of inclusive education largely depends on the professional competence of teachers, the reorganization of the system of professional training of future professionals. The features and level of readiness (according to the results of self-assessment in the interview) of future teachers for professional activity with children with special educational needs in the conditions of inclusion are studied. The positive attitude of students to the need for purposefully organized process of their professional preparation for work in inclusive educational institutions is recorded.