bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficaciousness of dexmedetomidine in children undergoing cleft lip and palate repair: a systematic review and meta-analysis
Authors: Liu Dengfeng , Pan Li , Gao Yin , Liu Jiefan , Li Feng , Li Xiangwei , Quan Jiale , Huang Congcong , Lian Chunwei 
Published: August 2021

ObjectiveTo systematically assess the efficacy and safety of dexmedetomidine as an anaesthesia adjuvant for cleft lip and palate (CLP) repair in children.DesignSystematic review and meta-analysis.Data sourcesPubMed, Embase, Cochrane, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP) and Wanfang (up to October 2020). Studies in languages other than English and Chinese were excluded.Eligibility criteria for selecting studiesRandomised controlled trials (RCTs) evaluating the impact of dexmedetomidine on emergence agitation (EA), the need for postoperative rescue analgesics, postoperative nausea and vomiting (PONV), and other adverse events in paediatric patients during CLP repair.Data extraction and synthesisThe quality of evidence was assessed by using the Cochrane Review Methods and the Grading of Recommendations Assessment, Development and Evaluation approach. Data were screened, extracted and assessed by two independent authors. Outcomes were reported as a risk ratio (RR) with a 95% CI. A random-effect model was used when heterogeneity was detected.ResultsThirteen studies including 1040 children met the inclusion criteria. The incidence of EA was significantly decreased in the dexmedetomidine group (RR, 0.19; 95% CI 0.10 to 0.36; p<0.00001; I2=56%) as compared with the control group. Paediatric patients receiving dexmedetomidine had lower postoperative analgesic requirements (RR, 0.27; 95% CI 0.10 to 0.73; p=0.01; I2=84%) and a lower incidence of respiratory adverse events (RR, 0.49; 95% CI 0.31 to 0.78; p=0.003; I2=0%). There were no significant differences in the risk of PONV and cardiovascular adverse events.ConclusionsThere was a lack of high-quality studies in this field. Perioperative administration of dexmedetomidine reduced the need for postoperative rescue analgesics and the incidence of EA in children without side effects undergoing CLP repair. However, further verification with larger samples and higher-quality RCTs is needed.
E-cigarette advertising exposure among South African adults in 2017: findings from a nationally representative cross-sectional survey
Authors: Agaku Israel Terungwa , Egbe Catherine O , Ayo-Yusuf Olalekan A 
Published: August 2021

ObjectivesIn South Africa, the Control of Tobacco and Electronic Delivery Systems Bill seeks to regulate e-cigarettes as tobacco products, including their advertising, promotion and sponsorship. Population data on e-cigarette advertising in South Africa are needed to inform public health programs, practice and policy. We examined self-reported e-cigarette advertising exposure during 2017.DesignCross-sectional.SettingHousehold-based survey.Participants3063 individuals who participated in the 2017 South African Social Attitudes survey, a nationally representative, in-person survey of the non-institutionalised civilian adult population aged ≥16 yearsExposure‘In the past 12 months, have you seen advertisements or promotions for e-cigarettes (including e-shisha, e-pipe) on any of the following media: newspapers/magazines, billboards, in the malls or any other source?’Main outcomesBeliefs and attitudes regarding e-cigarettes.FindingsParticipants’ mean age was 37.7 years. Overall, 20.1% reported exposure to e-cigarette advertisements. By age, exposure was most prevalent among those aged 16–19 years (24.6%). Top sources of exposure among those exposed were stores, 40.7%; malls, 30.9%; and television, 32.5%. Of those aware of e-cigarettes, 61.2% believed ‘e-cigarette advertisements and promotion may make adolescents think of smoking traditional cigarettes’; 62.7% believed that ‘e-cigarette advertisements and promotions may make ex-smokers think of starting smoking cigarettes again’; and 59.5% supported the statement that ‘e-cigarette smoking should be banned indoors just as traditional cigarette smoking’. Notably, teens aged 16–19 reported the lowest prevalence (49.0%) of those believing that ‘e-cigarette advertisements and promotion may make adolescents think of smoking traditional cigarettes’, whereas this percentage was highest among those aged 55–64 years (73.2%).ConclusionComprehensive regulatory efforts are needed to address e-cigarette advertising, marketing and sponsorship in order to protect public health. The urgent enactment of the new tobacco control legislation, The Control of Tobacco Products and Electronic Delivery Systems Bill, can help reduce youth exposure to e-cigarette advertising in South Africa.
Collaborative care model for depression in rural Nepal: a mixed-methods implementation research study
Authors: Rimal Pragya , Choudhury Nandini , Agrawal Pawan , Basnet Madhur , Bohara Bhavendra , Citrin David , Dhungana Santosh Kumar , Gauchan Bikash , Gupta Priyanka , Gupta Tula Krishna , Halliday Scott , Kadayat Bharat , Mahar Ramesh , Maru Duncan , Nguyen Viet , Poudel Sanjaya , Raut Anant , Rawal Janaki , Sapkota Sabitri , Schwarz Dan , Schwarz Ryan , Shrestha Srijana , Swar Sikhar , Thapa Aradhana , Thapa Poshan , White Rebecca , Acharya Bibhav 
Published: August 2021

IntroductionDespite carrying a disproportionately high burden of depression, patients in low-income countries lack access to effective care. The collaborative care model (CoCM) has robust evidence for clinical effectiveness in improving mental health outcomes. However, evidence from real-world implementation of CoCM is necessary to inform its expansion in low-resource settings.MethodsWe conducted a 2-year mixed-methods study to assess the implementation and clinical impact of CoCM using the WHO Mental Health Gap Action Programme protocols in a primary care clinic in rural Nepal. We used the Capability Opportunity Motivation-Behaviour (COM-B) implementation research framework to adapt and study the intervention. To assess implementation factors, we qualitatively studied the impact on providers’ behaviour to screen, diagnose and treat mental illness. To assess clinical impact, we followed a cohort of 201 patients with moderate to severe depression and determined the proportion of patients who had a substantial clinical response (defined as ≥50% decrease from baseline scores of Patient Health Questionnaire (PHQ) to measure depression) by the end of the study period.ResultsProviders experienced improved capability (enhanced self-efficacy and knowledge), greater opportunity (via access to counsellors, psychiatrist, medications and diagnostic tests) and increased motivation (developing positive attitudes towards people with mental illness and seeing patients improve) to provide mental healthcare. We observed substantial clinical response in 99 (49%; 95% CI: 42% to 56%) of the 201 cohort patients, with a median seven point (Q1:−9, Q3:−2) decrease in PHQ-9 scores (p<0.0001).ConclusionUsing the COM-B framework, we successfully adapted and implemented CoCM in rural Nepal, and found that it enhanced providers’ positive perceptions of and engagement in delivering mental healthcare. We observed clinical improvement of depression comparable to controlled trials in high-resource settings. We recommend using implementation research to adapt and evaluate CoCM in other resource-constrained settings to help expand access to high-quality mental healthcare.
Interventions to improve infant and young child feeding practices in Ethiopia: a systematic review
Authors: Ahmed Kedir Y. , Agho Kingsley Emwinyore , Page Andrew , Arora Amit , Ogbo Felix Akpojene 
Published: August 2021

ObjectiveIn Ethiopia, despite the implementation of several interventions to improve infant and young child feeding (IYCF) practices, no published studies have highlighted the most effective IYCF interventions in the country. This systematic review investigated the impacts of various interventions on IYCF in Ethiopia.Source of informationA systematic search was conducted on seven computerised bibliographic databases (Embase, ProQuest Central, Scopus, PsycINFO, Web of Science, MEDLINE/PubMed and CINAHL) to locate experimental or quasi-experimental studies published between the year 2000 and May 2021.Study eligibility criteriaInterventional studies that measured IYCF indicators (early initiation of breast feeding (EIBF), exclusive breast feeding (EBF), the introduction of complementary foods, minimum dietary diversity (MDD), minimum meal frequency (MMF) and minimum acceptable diet) as outcome variables were included.Study appraisal and synthesisAll included studies were examined for biases related to interventional studies (ie, selection bias, performance bias, attrition bias, detection bias and reporting bias). Author reports of effect size measures were used to narratively report the findings of each study.ResultsOf the 23 eligible studies, 14 studies were quasi-experimental and 9 studies were cluster randomised trials (CRTs). Eight quasi-experimental studies had a serious risk of bias, while two CRTs had a high risk of bias. Four studies for EBF and six studies for EIBF showed significant impacts of policy advocacy, health service strengthening, interpersonal communication, community mobilisation and mass media campaigns. Six studies for MDD and three studies for MMF indicated significant effects of community-level and health facility complementary feeding promotions on infants and young children. Interventions that delivered in combination increased the impacts in improving EIBF, MDD and MMF compared with a single intervention.ConclusionOur review showed that 12 out of 21 eligible studies that implemented in the form of community-level and health facility interventions improved EIBF, EBF, and/or MDD in Ethiopia.Protocol registration numberPROSPERO, CRD42020155519.
Experiences of preparing children for a death of an important adult during the COVID-19 pandemic: a mixed methods study
Authors: Rapa Elizabeth , Hanna Jeffrey R , Mayland Catriona R , Mason Stephen , Moltrecht Bettina , Dalton Louise J 
Published: August 2021

ObjectiveThe objectives of this study were to investigate how families prepared children for the death of a significant adult, and how health and social care professionals provided psychosocial support to families about a relative’s death during the COVID-19 pandemic.Design/settingA mixed methods design; an observational survey with health and social care professionals and relatives bereaved during the COVID-19 pandemic in the UK, and in-depth interviews with bereaved relatives and professionals were conducted. Data were analysed thematically.ParticipantsA total of 623 participants completed the survey and interviews were conducted with 19 bereaved relatives and 16 professionals.ResultsMany children were not prepared for a death of an important adult during the pandemic. Obstacles to preparing children included families’ lack of understanding about their relative’s declining health; parental belief that not telling children was protecting them from becoming upset; and parents’ uncertainty about how best to prepare their children for the death. Only 10.2% (n=11) of relatives reported professionals asked them about their deceased relative’s relationships with children. This contrasts with 68.5% (n=72) of professionals who reported that the healthcare team asked about patient’s relationships with children. Professionals did not provide families with psychosocial support to facilitate preparation, and resources were less available or inappropriate for families during the pandemic. Three themes were identified: (1) obstacles to telling children a significant adult is going to die, (2) professionals’ role in helping families to prepare children for the death of a significant adult during the pandemic, and (3) how families prepare children for the death of a significant adult.ConclusionsProfessionals need to: provide clear and honest communication about a poor prognosis; start a conversation with families about the dying patient’s significant relationships with children; and reassure families that telling children someone close to them is dying is beneficial for their longer term psychological adjustment.
The MCF10 Model of Breast Tumor Progression
Authors: Puleo Julieann , Polyak Kornelia 
Published: August 2021

Abstract
The MCF10 cell lines first described by Soule and colleagues in 1990 have been a great resource for the breast cancer research community, facilitating research on the regulation of normal breast epithelial phenotypes and progressive changes in this regulation during malignancy. Here we review the development of the MCF10 parental and subsequent sublines and highlight a few of the major contributions of MCF10 model systems to breast cancer research.
See related article by Soule and colleagues, Cancer Res 1990;50:6075–86
Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3-ITD Acute Myeloid Leukemia
Authors: Dumas Pierre-Yves , Villacreces Arnaud , Guitart Amélie V. , El-habhab Ali , Massara Layal , Mansier Olivier , Bidet Audrey , Martineau Delphine , Fernandez Solene , Leguay Thibaut , Pigneux Arnaud , Vigon Isabelle , Pasquet Jean-Max , Desplat Vanessa 
Published: August 2021

Abstract

Purpose:
AXL has been shown to play a pivotal role in the selective response of FLT3-ITD acute myeloid leukemia (AML) cells to FLT3 tyrosine kinase inhibitors (TKI), particularly within the bone marrow microenvironment.

Experimental Design:
Herein, we compared the effect of dual FLT3/AXL-TKI gilteritinib with quizartinib through in vitro models mimicking hematopoietic niche conditions, ex vivo in primary AML blasts, and in vivo with dosing regimens allowing plasma concentration close to those used in clinical trials.

Results:
We observed that gilteritinib maintained a stronger proapoptotic effect in hypoxia and coculture with bone marrow stromal cells compared with quizartinib, linked to a dose-dependent inhibition of AXL phosphorylation. In vivo, use of the MV4–11 cell line with hematopoietic engraftment demonstrated that gilteritinib was more effective than quizartinib at targeting leukemic cells in bone marrow. Finally, FLT3-ITD AML patient-derived xenografts revealed that this effect was particularly reproducible in FLT3-ITD AML with high allelic ratio in primary and secondary xenograft. Moreover, gilteritinib and quizartinib displayed close toxicity profile on normal murine hematopoiesis, particularly at steady state.

Conclusions:
Overall, these findings suggest that gilteritinib as a single agent, compared with quizartinib, is more likely to reach leukemic cells in their protective microenvironment, particularly AML clones highly dependent on FLT3-ITD signaling.
Targeted Transcriptome and KRAS Mutation Analysis Improve the Diagnostic Performance of EUS-FNA Biopsies in Pancreatic Cancer
Authors: Lundy Joanne , Gao Hugh , Berry William , Masoumi-Moghoddam Samar , Jenkins Brendan J. , Croagh Daniel 
Published: August 2021

Abstract

Purpose:
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis, and current diagnostic tests have suboptimal sensitivity. Incorporating standard cytology with targeted transcriptomic and mutation analysis may improve upon the accuracy of diagnostic biopsies, thus reducing the burden of repeat procedures and delays to treatment initiation.

Experimental Design:
We reviewed the accuracy of 308 endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) diagnostic PDAC biopsies using a large multicenter clinical and biospecimen database, then performed RNA sequencing on 134 EUS-FNA biopsies spanning all stages of disease. We identified a transcriptomic diagnostic gene signature that was validated using external datasets and 60 further diagnostic EUS-FNAs. KRAS digital droplet PCR (ddPCR) analysis was performed and correlated with signature gene expression.

Results:
The sensitivity of EUS-FNA cytology in diagnosing solid pancreatic masses in our retrospective cohort of 308 patients was 78.6% (95% confidence interval, 73.2%–83.2%). KRAS mutation analysis and our custom transcriptomic signature significantly improved upon the diagnostic accuracy of standard cytology to 91.3% in external validation sets and 91.6% in our validation cohort (n = 60). Exploratory ddPCR analysis of KRAS-mutant allele fraction (MAF%) correlated closely to signature performance and may represent a novel surrogate marker of tumor cellularity in snap-frozen EUS-FNA biopsies.

Conclusions:
Our findings support snap-frozen EUS-FNA biopsies as a feasible tissue source for the integrated genomic and transcriptomic analysis of patients presenting with PDAC from all tumor stages, including cases with nondiagnostic cytology. Our transcriptome-derived genetic signature in combination with tissue KRAS mutation analysis significantly improves upon the diagnostic accuracy of current standard procedures, and has potential clinical utility in improving the speed and accuracy of diagnosis for patients presenting with PDAC.
An improvement and a fast DSP implementation of the bit flipping algorithms for low density parity check decoder
Authors: Razi Mouhcine , Benhayoun Mhammed , Mansouri Anass , Ahaitouf Ali 
Published: August 2021

<span lang="EN-US">For low density parity check (LDPC) decoding, hard-decision algorithms are sometimes more suitable than the soft-decision ones. Particularly in the high throughput and high speed applications. However, there exists a considerable gap in performances between these two classes of algorithms in favor of soft-decision algorithms. In order to reduce this gap, in this work we introduce two new improved versions of the hard-decision algorithms, the adaptative gradient descent bit-flipping (AGDBF) and adaptative reliability ratio weighted GDBF (ARRWGDBF). An adaptative weighting and correction factor is introduced in each case to improve the performances of the two algorithms allowing an important gain of bit error rate. As a second contribution of this work a real time implementation of the proposed solutions on a digital signal processors (DSP) is performed in order to optimize and improve the performance of these new approchs. The results of numerical simulations and DSP implementation reveal a faster convergence with a low processing time and a reduction in consumed memory resources when compared to soft-decision algorithms. For the irregular LDPC code, our approachs achieves gains of 0.25 and 0.15 dB respectively for the AGDBF and ARRWGDBF algorithms.</span>
Contribution to the knowledge of the Neotropical Anteoninae (Hymenoptera, Dryinidae), with the descriptions of two new species and new records
Authors: Martins André Luis , Olmi Massimo 
Published: August 2021

Two new species of Anteoninae (Hymenoptera, Chrysidoidea, Dryinidae) are described: Deinodryinus brasiliensis sp. nov., from Brazil (Bahia, Minas Gerais and Paraná) and D. mexicanus sp. nov., from Mexico (Chiapas). Comments on Lonchodryinus tricolor Kieffer, 1905 are presented and new geographic records are provided for the Brazilian states of Minas Gerais and Paraná. The key to the females of the Neotropical Deinodryinus is updated, and illustrations and distributional maps are provided for the species studied here.
Taking the HIGHWAY to Save Lives on Lake Victoria
Authors: Roberts Rita D. , Goodman Steven J. , Wilson James W. , Watkiss Paul , Powell Robert , Petersen Ralph A. , Bain Caroline , Faragher John , Chang’a Ladislaus B. , Kapkwomu Julius Kiprop , Oloo Paul N. , Sebaziga Joseph N. , Hartley Andrew , Donovan Timothy , Mittermaier Marion , Cronce Lee , Virts Katrina S. 
Published: August 2021

Abstract
Up to 1,000 drowning deaths occur every year on Lake Victoria in East Africa. Nocturnal thunderstorms are one of the main culprits for the high winds and waves that cause fishing boats to capsize. The High Impact Weather Lake System (HIGHWAY) project was established to develop an Early Warning System for Lake Victoria. Prior to HIGHWAY, weather forecasts for the lake were overly general and not trusted. Under the HIGHWAY project, forecasters from weather service offices in East Africa worked with leaders of fishing communities and Beach Management Units to develop marine forecasts and hazardous-weather warnings that were meaningful to fishermen and other stakeholders. Forecasters used high-resolution satellite, radar, and lightning observations collected during a HIGHWAY field campaign, along with guidance from numerical weather prediction models and a 4.4-km resolution Tropical Africa model, to produce specific forecasts and warnings for 10 zones over the lake. Forecasts were communicated to thousands of people by radio broadcasters, local intermediaries, and via smartphones using the WhatsApp application. Fishermen, ferry-boat operators, and lakeside communities used the new marine forecasts to plan their daytime and nighttime activities on the lake. A socioeconomic benefits study conducted by HIGHWAY found that ∼75% of the people are now using the forecasts to decide if and when to travel on the lake. Significantly, a 30% reduction in drowning fatalities on the lake is likely to have occurred, which, when combined with the reduction in other weather-related losses, generates estimated socioeconomic benefits of $44 million per year due to the HIGHWAY project activities; the new marine forecasts and warnings are helping to save lives and property.
An Eulerian Scheme for Identifying Fronts and Vortices in Quasi-Balanced Flows
Authors: Bachman Scott D. 
Published: August 2021

AbstractThe identification of vortices in a fluid flow is a dynamically interesting problem that has practical applications in oceanography due to the outsized role eddies play in water mass, heat, and tracer transport. Here a new Eulerian scheme is developed to detect both vortices and strongly strained fronts, which are both ubiquitous in the World Ocean. The new scheme is conceptually linked to the well-known Okubo–Weiss parameter, but is extended to quasigeostrophic flows by recognizing the strong role played by vertical shear in ocean dynamics. Adapted from the 2 criterion for vortex identification, the scheme considers the curvature of the pressure field as the differentiator between vortical and strained flow structures, and it is shown that its underlying geometry also exhibits characteristics of quasigeostrophic flow. The uses and skill of the scheme are demonstrated using a high-resolution regional ocean simulation, and prospects for its use with observational products are discussed.