bluuebunny/crossref_metadata_2025_split huggingface dataset:
Damage mechanisms of bisphenols on the quality of mammalian oocytes
Authors: Pandey Ashutosh N , Yadav Pramod K , Premkumar Karuppanan V , Tiwari Meenakshi , Antony Mano Mohan , Pandey Ajai K , Chaube Shail K 
Published: December 2024

Abstract
The extensive use of bisphenols in the plastics industry globally is a major growing concern for human health. Bisphenol compounds are easily leached out from plastic containers to food, beverages, and drinking water and contaminate the natural environment. Daily exposure of bisphenol compounds increases their load and impairs various organs, including the reproductive system. Bisphenol compounds directly or indirectly affect ovarian functions, such as folliculogenesis, steroidogenesis, oogenesis, and thereby oocyte quality. Bisphenol A (BPA) and its structural analogues act as endocrine disruptors and induce generation of reactive oxygen species (ROS) within the ovary. Excess levels of ROS induce death pathways in follicular steroidogenic cells and affect ovarian steroidogenesis. The reduced level of estradiol-17β impairs follicular growth and development that reduces the number and quality of oocytes. In addition, excess levels of ROS in follicular fluid trigger meiotic instability, which further deteriorates oocyte quality. The high level of ROS generates oxidative stress that triggers various death pathways in germ cells as well as in oocytes, induces follicular atresia, and depletes ovarian reserve. Although growing evidence indicates the destructive effects of bisphenol compounds at the level of ovary, potential effects and underlying mechanisms that deteriorate oocyte quality remain poorly understood. Therefore, this review summarizes the mechanisms by which bisphenols cause damage to the ovary, impair oocyte quality, and affect women's fertility.
Effects of a preweaning socialization system on piglet livability, lifetime growth performance, and subsequent sow performance
Authors: Becker Larissa L , Giacomini Paula , Tokach Mike D , Goodband Robert D , DeRouchey Joel M , Woodworth Jason C , Lerner Annie B , Gebhardt Jordan T 
Published: December 2024

Abstract
A total of 3,307 (PIC L 42) sows and 55,160 piglets were used to determine the effects of different farrowing systems on piglet livability and lifetime growth performance. Treatments were assigned to farrowing rooms and consisted of a conventional farrowing system (sows and piglets housed in individual farrowing stalls) or a preweaning socialization system (stall dividers removed between farrowing stalls and walkways within 6 to 24 h post-farrowing such that 12 to 32 litters of piglets were co-mingled). A total of 40 farrowing rooms with 80 stalls each were used with 20 rooms per treatment. Pigs were weaned at approximately 23 d of age. No differences were observed in lactation length, total born, born alive, stillborn, mummies, or number of pigs weaned. Pre-wean mortality was increased (P &lt; 0.001) for pigs from the preweaning socialization system compared to the conventional farrowing system (14.7% vs. 12.6%, respectively). At weaning, a subset of offspring (4,313 pigs initially 5.4 ± 0.15 kg) were transported to a commercial research facility to evaluate lifetime performance. Weaning weights were heavier (P &lt; 0.001) for pigs in the conventional farrowing system compared to the preweaning socialization system. Pigs were housed in pens according to sow treatment with 44 to 46 pigs per pen and 48 pens per treatment. During the nursery and finishing periods, pigs from the conventional farrowing system had increased (P &lt; 0.001) body weight (BW), average daily gain (ADG), and average daily feed intake (ADFI), but decreased gain-to-feed (G:F) compared to the preweaning socialization system. In the nursery phase, removals, mortality, and total removals and mortality were greater (P ≤ 0.059) for pigs raised in the preweaning socialization system than the conventional farrowing system, but no differences were observed in the finishing phase. Overall (days 23 to 183), pigs from the conventional farrowing system had increased (P ≤ 0.001) BW, ADG, and ADFI, but decreased (P = 0.010) G:F compared to the preweaning socialization system. No differences were observed for overall removals and mortality after weaning. Pigs from the conventional farrowing system had increased (P ≤ 0.094) live BW, hot carcass weight, carcass yield, loin depth, and percentage lean compared to the preweaning socialization system. No differences were observed in backfat. In summary, pigs raised in a conventional farrowing system had increased livability, lifetime growth performance, and improved carcass characteristics compared to the preweaning socialization system.
Peri-Implant Enhancement of the Breast: Imaging Features, Significance, and Management Strategies
Authors: Maimone Santo , Srivastava Shweta , Ho Olivia S , Robinson Kristin A , Morozov Andrey P , Letter Haley P , Leon Amie , Rinker Brian D 
Published: December 2024

Abstract

Objective
Peri-implant enhancement can be seen on contrast-enhanced breast MRI, but its association with malignancy has not been described, leading to considerable variability in assessment and recommendations by radiologists. This study evaluated imaging features, management, and outcomes of implant-related enhancement.

Methods
This multisite IRB-approved retrospective review queried all breast MRI reports for keywords describing peri-implant enhancement, fluid, and/or masses (plus synonymous descriptions) and implant-associated malignancies, with subsequent imaging and chart review. Peri-implant enhancement and implant features were characterized. Assessments and outcomes were evaluated via clinical and imaging follow-up, aspiration/biopsy, and/or capsulectomy to evaluate for association of peri-implant enhancement with implant-related malignancy.

Results
A total of 100 patients had peri-implant enhancement. Uniform thin peripheral enhancement was most common (79/100, 79%). Capsulectomy was performed in 31/100 (31%), with benign capsular fibrosis/inflammation discovered in 26/31 (83.9%). Breast implant–associated anaplastic large cell lymphoma was present in 2/100 (2%), both with textured implants, while 98/100 (98%) had no implant-related malignancy. MRI recommendations varied: resume routine imaging (26/100, 26%), clinical management (18/100, 18%), follow-up MRI (17/100, 17%), MRI-directed US (17/100, 17%), aspiration/biopsy (11/100, 11%), and surgical consultation (10/100, 10%).

Conclusion
Peri-implant enhancement is a nonspecific imaging finding with a low malignant association, especially when seen in isolation (no associated effusion, mass, or adenopathy). Implant surface texture should be considered in management recommendations; diagnostic capsulectomy is not recommended in patients with smooth implants. Additional studies are encouraged to validate nonoperative management recommendations.
Effect of fast and slow-acting bait toxicants on tawny crazy ant (Hymenoptera: Formicidae) foraging and nesting in the field
Authors: Oi David H , Atchison Rachel A , Read Quentin D 
Published: December 2024

Abstract
Tawny crazy ants (TCAs), Nylanderia fulva (Mayr) are an invasive species that develops extremely large populations that overrun landscapes. Control measures frequently rely on spraying contact insecticides, which often are inadequate. To provide insights for utilizing baits for their control, TCA foraging behavior was examined on liquid ant bait formulations that contained either fast-acting dinotefuran or slow-acting disodium octaborate tetrahydrate (DOT), and the impacts of these baits were assessed. Bayesian modeling of counts from time-lapse photography of TCA feeding on the baits and a control of sucrose solution in the field revealed strong evidence of similar foraging intensities between the control and the DOT bait and less foraging intensity on the dinotefuran bait. TCA abundance on the dinotefuran bait peaked within 8 h, then diminished to smaller feeding bouts over the 3-day study. In contrast, foraging on the DOT and control remained consistently high before bait depletion. The impact of the fast and slow-acting baits in field plots were based on TCA nest sizes and TCA abundance on sausage lures. Bayesian modeling predictions revealed nest sizes declined over the 2 months with bait present while the control had large nests. Abundance on the lures in the dinotefuran plots declined from the start of the study, while with the slow-acting DOT bait, declines in abundance were not lower than the control plot until 30 days after baiting was initiated. Further refinements in baiting with liquid baits containing fast and slow acting active ingredients may provide fast and sustained control of TCA.
Spatial distribution and sequential sampling plan for Oligonychus punicae (Acari: Trombidiformes: Tetranychidae) on grapevine
Authors: Melo André S , Oliveira José Eudes M , Melo José Wagner S , Gondim-Junior Manoel G C 
Published: December 2024

Abstract
Sequential sampling plans are employed for the rapid characterization of infestations to facilitate decision-making. This study aimed to (i) investigate the spatial distribution of Oligonychus punicae (Hirst) in grapevine crops, (ii) determine the most representative branch, leaf, and leaf region for monitoring, and (iii) develop a sequential sampling plan for decision-making to control O. punicae in the table grape varieties Arra 15, BRS Vitória, Cotton Candy, Sugar Crisp, and Timpson at different phenological stages. O. punicae distribution was analyzed across all varieties and developmental stages. Notably, O. punicae distribution varied among the tested varieties, with no consistent pattern observed in branches and leaves. However, a distinct distribution pattern was evident within leaves, with larger populations concentrated in the central regions. The lower and upper economic thresholds implement control measures varied according to the phenological stage, with the lower thresholds (economic threshold) set at 36% and the upper thresholds (economic injury level) at 40%. Consequently, a minimum of 3 and maximum of 20 plants were sampled. Overall, this study provides a robust approach to optimizing resource allocation and minimizing the environmental impact of O. punicae management.
Whose [Crime] is it Anyway?
Authors: Carpenter Christine 
Published: December 2024

Abstract
The concurrent increase in states’ cyber-capabilities and in the potential (mis)uses of artificial intelligence (AI) to further harmful state objectives raise the question: is ICL prepared to grapple with AI-powered cyberattacks conducted by and against states? Or does AI’s conduct run the risk of falling into a legal loophole, shielding from liability the human actors who commissioned its use? Addressing these questions, this article analyses how AI impacts ICL’s fundamental elements of international crimes — namely, the requirements of actus reus and mens rea. Specifically examining the literature’s more recently explored notion of the crime of ‘cyber-aggression’, this article scrutinizes the efficacy of the current text and interpretation of the Rome Statute in according international criminal responsibility where AI causes an act of cyber-aggression. It examines the spectrum on which potential acts of cyber-aggression may be fairly ‘reduced to human activity’, and thus where criminal responsibility may flow to the AI’s human instructor, versus where the act committed was perhaps too removed from human intervention to justify criminal responsibility under the applicable culpable mental state. In this article, the author argues the elements for criminal responsibility of an act of aggression, in their current construction and interpretation, are ill-prepared when faced with the murky implications of cyber-aggression conducted via state-backed AI systems. In order to engage in such a discussion, this article proceeds by providing an overview of the crime of aggression and introducing the emerging concept of ‘cyber-aggression’. Then, the article explores the challenges AI-powered acts of aggression present for the conventional elements of international criminal responsibility. Finally, the article details solutions posed by the literature and proposes an additional approach, before offering concluding remarks.
Assessment of heterogeneity according to hospital or medical experience factors in outcomes of chemotherapy for advanced biliary tract cancer: a post-hoc analysis of JCOG1113
Authors: Fukushi Koh , Imaoka Hiroshi , Ikeda Masafumi , Mizusawa Junki , Morizane Chigusa , Okusaka Takuji , Kobayashi Satoshi , Sasahira Naoki , Shimizu Satoshi , Yamazaki Kentaro , Okano Naohiro , Miwa Haruo , Hara Kazuo , Satoi Sohei , Sano Keiji , Sakai Kenji , Sugimoto Rie , Nakamura Kazuyoshi , Terashima Takeshi , Ozaka Masato , Ueno Makoto ,   JCOG Hepatobiliary and Pancreatic Oncology Group, Fukushi Koh , Imaoka Hiroshi , Ikeda Masafumi , Morizane Chigusa , Okusaka Takuji , Kobayashi Satoshi , Sasahira Naoki , Shimizu Satoshi , Yamazaki Kentaro , Okano Naohiro , Miwa Haruo , Hara Kazuo , Satoi Sohei , Sano Keiji , Sakai Kenji , Sugimoto Rie , Nakamura Kazuyoshi , Terashima Takeshi , Ozaka Masato , Ueno Makoto , Mizusawa Junki 
Published: December 2024

Abstract

Background
JCOG1113 is a randomized phase III trial that showed non-inferiority of gemcitabine plus S-1 to gemcitabine plus cisplatin in patients with advanced biliary tract cancer. Assessment of inter-institutional heterogeneity in chemotherapy contributes to confirm generalizability and reliability of the study itself. However, there have been no studies conducted to assess the heterogeneity among participating centers in randomized phase III trials for biliary tract cancer.

Methods
The objective of this post-hoc analysis was to assess the inter-institutional heterogeneity in the overall survival and progression-free survival of patients with advanced biliary tract cancer treated with first-line chemotherapy in the JCOG1113 trial. The heterogeneity in the overall survival and progression-free survival was assessed according to three factors: hospital volume, experience in medical oncology and experience in biliary intervention. A total of 300 advanced biliary tract cancer patients were analyzed. There were no statistically significant trends observed between hospital volume, experience in medical oncology, or experience in biliary intervention and overall survival (hospital volume: adjusted trend P value = 0.6796; experience in medical oncology: adjusted trend P value = 0.4092; experience in biliary intervention: adjusted trend P value = 0.6112). Similarly, no statistically significant trends were observed between these factors and progression-free survival (hospital volume: adjusted trend P value = 0.3000; experience in medical oncology: adjusted trend P value = 0.1108; experience in biliary intervention: adjusted trend P value = 0.2898).

Conclusions
This study revealed no inter-institutional heterogeneity in the overall survival and progression-free survival in the JCOG1113 study population of advanced biliary tract cancer patients.
Larval competition between the invasive Aedes aegypti (Diptera: Culicidae) and the Caribbean endemic Aedes mediovittatus (Diptera: Culicidae) from Puerto Rico, USA
Authors: Yee Donald A , Nelsen Joseph A , Fijman Nicole S , Reyes-Torres Limarie J , Everly Jaclyn , Eastmond Bradley , Alto Barry W 
Published: December 2024

Abstract
Competition between mosquito species during the larval phase is a well-established mechanism structuring container mosquito communities, with invasive species often outperforming natives. We assessed the competitive outcome between 2 species that occur on the island of Puerto Rico, the historic invasive Aedes aegypti (L.) and the endemic Aedes mediovittatus (Coquillett) (Diptera: Culicidae). Trials were conducted under intra- and interspecific densities crossed with 2 amounts of 4 different leaf types serving as detrital resources for developing larvae; leaf types were representative of either urban or rural locations. Response variables included survival, male and female mass and development time, and a composite index of population growth (λʹ). We also measured tannin levels in detrital environments, a secondary metabolite that can negatively influence mosquito development and survival. The co-occurrence of Ae. aegypti and Ae. mediovittatus generally did not affect survival or population growth of Ae. mediovittatus, however the converse was not true. Specifically, Ae. aegypti suffered lower survival and lower population growth in the presence of Ae. mediovittatus compared to when it was alone. Tannin concentrations did not correspond to competitive outcomes, as the highest tannin levels occurred under the detrital conditions where mosquitoes had highest growth and survival, with no evidence of differences between urban or rural leaf types. This is the first study to quantify the competitive outcomes between these species, both of which are part of the dengue transmission cycle on the island, and our findings suggest that Ae. mediovittatus is capable of outcompeting Ae. aegypti under some resource environments.
Root RADAR: how ‘rhizocrine’ signals allow roots to detect and respond to their soil environment and stresses
Authors: Pandey Bipin K , George Timothy S , Cooper Hannah V , Sturrock Craig J , Bennett Tom , Bennett Malcolm J 
Published: December 2024

Abstract
Agricultural intensification coupled with changing climate are causing soils to become increasingly vulnerable to stresses such as drought, soil erosion, and compaction. The mechanisms by which roots detect and respond to soil stresses remain poorly understood. Recent breakthroughs show that roots release volatile and soluble hormone signals into the surrounding soil, then monitor their levels to sense soil stresses. Our review discusses how hormones can act ‘outside the plant’ as ‘rhizocrine’ signals that function to improve plant resilience to different soil stresses. We also propose a novel signalling paradigm which we term ‘root RADAR’ where ‘rhizocrine’ levels change in soil in response to environmental stresses, feeding back to roots and triggering adaptive responses.
Uncovering the truth about M101, NGC 3938, and their significant others through radiative transfer
Authors: Pricopi D , Popescu C C , Rushton M T , Murphy D , Inman C J , Toma R 
Published: December 2024

ABSTRACT
Solving the inverse problem in spiral galaxies, that allows the derivation of the spatial distribution of dust, gas, and stars, together with their associated physical properties, directly from panchromatic imaging observations, is one of the main goals of this work. To this end, we used radiative transfer models to decode the spatial and spectral distributions of the nearby face-on galaxies M101 and NGC 3938. In both cases, we provide excellent fits to the surface-brightness distributions derived from GALEX, SDSS, 2MASS, Spitzer, and Herschel imaging observations. Together with previous results from M33, NGC 628, M51, and the Milky Way, we obtain a small statistical sample of modelled nearby galaxies that we analyse in this work. We find that in all cases Milky Way-type dust with Draine-like optical properties provide consistent and successful solutions. We do not find any ‘submm excess’, and no need for modified dust-grain properties. Intrinsic fundamental quantities like star-formation rates (SFR), specific SFR (sSFR), dust opacities, and attenuations are derived as a function of position in the galaxy and overall trends are discussed. In the SFR surface density versus stellar mass surface density space, we find a structurally resolved relation (SRR) for the morphological components of our galaxies, that is steeper than the main sequence (MS). Exception to this is for NGC 628, where the SRR is parallel to the MS.
Formation of giant clumps in high-z disc galaxies by compressive turbulence
Authors: Mandelker Nir , Ginzburg Omry , Dekel Avishai , Bournaud Frederic , Krumholz Mark R , Ceverino Daniel , Primack Joel 
Published: December 2024

ABSTRACT
We address the formation of giant clumps in violently unstable gas-rich disc galaxies at cosmic noon. While these are commonly thought to originate from gravitational Toomre instability, some cosmological simulations have indicated that clumps can form in Lagrangian proto-clump regions where the Toomre Q parameter is well above unity, which are linearly stable. Examining one of these cosmological simulations, we find that it exhibits an excess in compressive modes of turbulence with converging motions. The energy in converging motions within proto-clumps is ${\sim} 70~{{\ \rm per\ cent}}$ of the total turbulent energy, compared to ${\sim} 17~{{\ \rm per\ cent}}$ expected in equipartition. When averaged over the whole disc, ${\sim} 40~{{\ \rm per\ cent}}$ of the turbulent energy is in compressive modes, mostly in converging motions, with the rest in solenoidal modes, compared to the $(1/3)-(2/3)$ division expected in equipartition. By contrast, we find that in an isolated-disc simulation with similar properties, resembling high-z star-forming galaxies, the different turbulence modes are in equipartition, both in proto-clumps and over the whole disc. We conclude that the origin of excessive converging motions in proto-clumps is external to the disc, and propose several mechanisms that can induce them. This is an additional mechanism for clump formation, complementary to and possibly preceding gravitational instability.
The potential of GPT-4 advanced data analysis for radiomics-based machine learning models
Authors: Foltyn-Dumitru Martha , Rastogi Aditya , Cho Jaeyoung , Schell Marianne , Mahmutoglu Mustafa Ahmed , Kessler Tobias , Sahm Felix , Wick Wolfgang , Bendszus Martin , Brugnara Gianluca , Vollmuth Philipp 
Published: December 2024

Abstract

Background
This study aimed to explore the potential of the Advanced Data Analytics (ADA) package of GPT-4 to autonomously develop machine learning models (MLMs) for predicting glioma molecular types using radiomics from MRI.

Methods
Radiomic features were extracted from preoperative MRI of n = 615 newly diagnosed glioma patients to predict glioma molecular types (IDH-wildtype vs IDH-mutant 1p19q-codeleted vs IDH-mutant 1p19q-non-codeleted) with a multiclass ML approach. Specifically, ADA was used to autonomously develop an ML pipeline and benchmark performance against an established handcrafted model using various MRI normalization methods (N4, Zscore, and WhiteStripe). External validation was performed on 2 public glioma datasets D2 (n = 160) and D3 (n = 410).

Results
GPT-4 achieved the highest accuracy of 0.820 (95% CI = 0.819-0.821) on the D3 dataset with N4/WS normalization, significantly outperforming the benchmark model’s accuracy of 0.678 (95% CI = 0.677-0.680) (P &lt; .001). Class-wise analysis showed performance variations across different glioma types. In the IDH-wildtype group, GPT-4 had a recall of 0.997 (95% CI = 0.997-0.997), surpassing the benchmark’s 0.742 (95% CI = 0.740-0.743). For the IDH-mut 1p/19q-non-codel group, GPT-4’s recall was 0.275 (95% CI = 0.272-0.279), lower than the benchmark’s 0.426 (95% CI = 0.423-0.430). In the IDH-mut 1p/19q-codel group, GPT-4’s recall was 0.199 (95% CI = 0.191-0.206), below the benchmark’s 0.730 (95% CI = 0.721-0.738). On the D2 dataset, GPT-4’s accuracy was significantly lower (P &lt; .001) than the benchmark’s, with N4/WS achieving 0.668 (95% CI = 0.666-0.671) compared with 0.719 (95% CI = 0.717-0.722) (P &lt; .001). Class-wise analysis revealed the same pattern as observed in D3.

Conclusions
GPT-4 can autonomously develop radiomics-based MLMs, achieving performance comparable to handcrafted MLMs. However, its poorer class-wise performance due to unbalanced datasets shows limitations in handling complete end-to-end ML pipelines.