bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies on natural gas reserves multi-cycle growth law in Sichuan Basin based on multi-peak identification and peak parameter prediction
Authors: Li Haitao , Yu Guo , Fang Yizhu , Chen Yanru , Wang Chenyu , Zhang Dongming 
Published: June 2021

AbstractResearch on predicting the growth trend of natural gas reserves will help provide theoretical guidance for natural gas exploration in Sichuan Basin. The growth trend of natural gas reserves in Sichuan Basin is multi-cycle and complex. The multi-cyclic peak is screened by the original multi-cyclic peak judgment standard. Metabolically modified GM(1,3) gray prediction method is used to predict the multi-cycle model parameters. The multi-cycle Hubbert model and Gauss model are used to predict the growth trend of natural gas reserves. The research results show that: (1) The number of cycles of natural gas reserves curve during 1956–2018 is 13. Natural gas reserves will maintain the trend of rapid growth in the short term. (2) Metabolism modified GM(1,3) gray prediction model can improve the accuracy of model prediction. The prediction accuracy of Hubbert model is higher than that of Gauss model. By 2030, the cumulative proven level of natural gas will reach 52.34%. The Sichuan Basin will reach its peak of proven lifetime reserves in the next few years.
Insight on the inhibitive property of potassium ion on the stability of shale: a diffuse double-layer thickness (κ−1) perspective
Authors: AL-Bazali Talal 
Published: June 2021

AbstractIt is believed that potassium ions reduce the hydration energy and swelling of clays and thus promoting stability to shales. This belief was made based on volumetric and linear expansion data obtained from shale and KCl solutions interactions. However, swelling data alone is not adequate to mitigate wellbore instability in shale. Such data must be incorporated with mechanical and physicochemical data for complete and accurate wellbore instability analysis.This paper presents clear experimental evidence showing that concentrated potassium chloride solutions tend to suppress shale swelling as higher concentration of potassium ions collapses the diffuse double layer of clay particles causing shale shrinkage which confirms the notion that the Debye length (κ−1) decreases as the ionic concentration increases.Results show that there exists a KCl concentration threshold above which shale’s compressive strength deteriorates significantly. This concentration threshold was found to hover around 5% by weight. The amount of water and ions uptake into shale was quantified using gravimetric measurements. Significant potassium ions invasion into shale was experimentally measured as KCl solution concentration increased which proved the leaky nature of shale’s membrane. The reduction of shale’s compressive strength seems to be well correlated with the amount of ions uptake into shale. Moreover, data suggests that shale’s compressive strength was not significantly impacted by swelling. It was possible to gravimetrically separate osmotic water from associated water as shale interacted with KCl solutions. Results suggest that osmotic water is responsible for shale swelling since it is unattached to ions which makes it free to move around inside shale. On the other hand, data suggest that associated water does not contribute to shale swelling as it is bound to potassium ions which makes it unfree to move around. It is fair to state, based on our experimental data, that osmotic water is responsible for shale swelling while associated water contributes to shale’s compressive strength alteration.
Ultrasound and shear-wave elastography patterns of COVID-19 mRNA vaccine-related axillary, supra and subclavicular lymphadenopathy
Authors: D’Auria Divina , Fulgione Ludovica , Romeo Valeria , Stanzione Arnaldo , Maurea Simone , Brunetti Arturo 
Published: June 2021

AbstractIn this pictorial essay, we illustrate the ultrasound appearance of COVID-19 Pfizer-BioNTech vaccine-related lymph node abnormalities, which can occur at different stations ipsilateral to the site of vaccination, after either first or second vaccine dose and can represent a diagnostic dilemma when encountered in patients with underlying conditions. Typically, they appear as enlarged hypoechoic nodes with loss of fat hilum, increased hilar and cortical vascularization at color-Doppler, but low to intermediate cortical consistence at shear-wave elastography. Asymmetric or diffuse cortical thickening is also frequently encountered. They can be observed in patients without and with clinical symptoms, such as armpit pain, fever and fatigue.
Attack graph reachability: concept, analysis, challenges and issues
Authors: Al-Araji Zaid J , Ahmed Sharifah Sakinah Syad , Abdullah Raihana Syahirah , Mutlag Ammar Awad , Raheem Hayder Adil Abdul , Basri Siti Rohanah Hasan 
Published: June 2021

An attack graph (AG) is an abstraction that represents the paths by which an attacker could break a security policy, leveraging interdependencies among discovered vulnerabilities. However, current AG implementations are inefficient on large-scale networks. The increase of the number of hosts in networks causes an increase in the time it takes to generate the AG, especially the calculation time and the complexity of determining reachability.An attack graph (AG) is an abstraction that represents the paths by which an attacker could break a security policy, leveraging interdependencies among discovered vulnerabilities.However, current AG implementations are inefficient on large-scale networks. The increase of the number of hosts in networks causes an increase in the time it takes to generate the AG, especially the calculation time and the complexity of determining reachability. In this article, the authors examine techniques that calculate the reachability using a matrix or a hyper-graph.
Infection Prevention Considerations for a Multi-Mission Convention Center Field Hospital in Baltimore, Maryland, During the COVID-19 Pandemic
Authors: Jones Jennifer A. , Siddiqui Zishan K. , Callahan Charles , Leekha Surbhi , Smyth Sharon , Preas Michael Anne , Ficke James R. , Cabunoc Marie Kristine F. , Kantsiper Melinda E. ,   the CONQUER COVID Consortium
Published: June 2021

AbstractThe state of Maryland identified its first case of coronavirus disease 2019 (COVID-19) on March 5, 2020. The Baltimore Convention Center (BCCFH) quickly became a selected location to set up a 250-bed inpatient field hospital and alternate care site. In contrast to other field hospitals throughout the United States, the BCCFH remained open throughout the pandemic and took on additional COVID-19 missions, including community severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic testing, monoclonal antibody infusions for COVID-19 outpatients, and community COVID-19 vaccinations.To prevent the spread of pathogens during operations, infection prevention and control guidelines were essential to ensure the safety of staff and patients. Through multi-agency collaboration, use of infection prevention best practices, and answering what we describe as PPE-ESP, an operational framework was established to reduce infection risks for those providing or receiving care at the BCCFH during the COVID-19 pandemic.
Queer Rumors: Protestant Ministers, Unnatural Deeds, and Church Censure in the Twentieth-Century United States
Authors: Krivulskaya Suzanna 
Published: June 2021

ABSTRACTOver the course of the twentieth century, dozens of conservative Protestant ministers were accused of sexual deviance—including instances of same-sex acts and attractions. Protestant churches, in turn, experimented with employing various tactics to undermine and challenge such accusations. From silencing and secrecy to public censure and disassociation, denominational bodies labored to undermine evidence of queerness among their ministers. This essay surveys a one-hundred-year history of religious groups’ and institutions’ attempts at dealing with the uncomfortable but persistent allegations of not-quite-straightness among their leaders. This story accounts for how conservative Protestantism has been able to maintain its claims to a particular kind of sexual morality even as religious leaders themselves have repeatedly jeopardized this project.
TIME-INTEGRATED COLLECTION OF CO2FOR14C ANALYSIS FROM SOILS
Authors: Pedron Shawn , Xu X , Walker J C , Ferguson J C , Jespersen R G , Welker J M , Klein E S , Czimczik C I 
Published: June 2021

ABSTRACTWe developed a passive sampler for time-integrated collection and radiocarbon (14C) analysis of soil respiration, a major flux in the global C cycle. It consists of a permanent access well that controls the CO2uptake rate and an exchangeable molecular sieve CO2trap. We tested how access well dimensions and environmental conditions affect collected CO2, and optimized cleaning procedures to minimize14CO2memory. We also deployed two generations of the sampler in Arctic tundra for up to two years, collecting CO2over periods of 3 days–2 months, while monitoring soil temperature, volumetric water content, and CO2concentration. The sampler collects CO2at a rate proportional to the length of a silicone tubing inlet (7–26 µg CO2-C day-1·m Si-1). With constant sampler dimensions in the field, CO2recovery is best explained by soil temperature. We retrieved 0.1–5.3 mg C from the 1st and 0.6–13 mg C from the 2nd generation samplers, equivalent to uptake rates of 2–215 (n=17) and 10–247 µg CO2-C day-1(n=20), respectively. The method blank is 8 ± 6 µg C (mean ± sd,n=8), with a radiocarbon content (fraction modern) ranging from 0.5875–0.6013 (n=2). The sampler enables more continuous investigations of soil C emission sources and is suitable for Arctic environments.
Effect of aminoethoxyvinylglycine (AVG) on quality, berry set and coloration of ‘Alphonse Lavallée’ table grapes
Authors: Babalık Zehra 
Published: June 2021

AbstractThe effect of different concentrations of aminoethoxyvinylglycine (AVG; 0 (control), 250, 500, 750 and 1000 mg/l), an ethylene biosynthesis inhibitor, on grape berry set and fruit quality was evaluated under vineyard conditions. Treatments were performed on ‘Alphonse Lavallée’ grape cultivar at full bloom stage for two years. Cluster and berry growth (length, width and weight), firmness, soluble solids content, yield, berry set, anthocyanin content and colour parameters were determined on treated and untreated (control) fruits. As a result of the study, the effects of AVG concentrations on firmness were not significant. When AVG applications were compared with control, it is determined that some quality properties were statistically affected, the others were not. Fruit set was increased by lower concentrations of AVG (250 mg/l) and anthocyanin content was increased by higher concentrations of AVG (750 mg/l).
On convex holes in d-dimensional point sets
Authors: Bukh Boris , Chao Ting-Wei , Holzman Ron 
Published: June 2021

AbstractGiven a finite set $A \subseteq \mathbb{R}^d$, points $a_1,a_2,\dotsc,a_{\ell} \in A$ form an $\ell$-hole in A if they are the vertices of a convex polytope, which contains no points of A in its interior. We construct arbitrarily large point sets in general position in $\mathbb{R}^d$ having no holes of size $O(4^dd\log d)$ or more. This improves the previously known upper bound of order $d^{d+o(d)}$ due to Valtr. The basic version of our construction uses a certain type of equidistributed point sets, originating from numerical analysis, known as (t,m,s)-nets or (t,s)-sequences, yielding a bound of $2^{7d}$. The better bound is obtained using a variant of (t,m,s)-nets, obeying a relaxed equidistribution condition.
TOROIDAL q-OPERS
Authors: Koroteev Peter , Zeitlin Anton M. 
Published: June 2021

AbstractWe define and study the space of q-opers associated with Bethe equations for integrable models of XXZ type with quantum toroidal algebra symmetry. Our construction is suggested by the study of the enumerative geometry of cyclic quiver varieties, in particular the ADHM moduli spaces. We define

$\left (\overline {GL}(\infty ),q\right )$
-opers with regular singularities and then, by imposing various analytic conditions on singularities, arrive at the desired Bethe equations for toroidal q-opers.
Impact of Sea‐Ice Dynamics on the Spatial Distribution of Diatom Resting Stages in Sediments of the Pacific Arctic Region
Authors: Fukai Yuri , Matsuno Kohei , Fujiwara Amane , Suzuki Koji , Richlen Mindy L. , Fachon Evangeline , Anderson Donald M. 
Published: June 2021

AbstractThe Pacific Arctic region is characterized by seasonal sea‐ice, the spatial extent and duration of which varies considerably. In this region, diatoms are the dominant phytoplankton group during spring and summer. To facilitate survival during periods that are less favorable for growth, many diatom species produce resting stages that settle to the seafloor and can serve as a potential inoculum for subsequent blooms. Since diatom assemblage composition is closely related to sea‐ice dynamics, detailed studies of biophysical interactions are fundamental to understanding the lower trophic levels of ecosystems in the Pacific Arctic. One way to explore this relationship is by comparing the distribution and abundance of diatom resting stages with patterns of sea‐ice coverage. In this study, we quantified viable diatom resting stages in sediments collected during summer and autumn 2018 and explored their relationship to sea‐ice extent during the previous winter and spring. Diatom assemblages were clearly dependent on the variable timing of the sea‐ice retreat and accompanying light conditions. In areas where sea‐ice retreated earlier, open‐water species such as Chaetoceros spp. and Thalassiosira spp. were abundant. In contrast, proportional abundances of Attheya spp. and pennate diatom species that are commonly observed in sea‐ice were higher in areas where diatoms experienced higher light levels and longer day length in/under the sea‐ice. This study demonstrates that sea‐ice dynamics are an important determinant of diatom species composition and distribution in the Pacific Arctic region.
High spectro-temporal compression on a nonlinear CMOS-chip
Authors: Choi Ju Won , Sahin Ezgi , Sohn Byoung-Uk , Chen George F. R. , Ng Doris K. T. , Agarwal Anuradha M. , Kimerling Lionel C. , Tan Dawn T. H. 
Published: June 2021

AbstractOptical pulses are fundamentally defined by their temporal and spectral properties. The ability to control pulse properties allows practitioners to efficiently leverage them for advanced metrology, high speed optical communications and attosecond science. Here, we report 11× temporal compression of 5.8 ps pulses to 0.55 ps using a low power of 13.3 W. The result is accompanied by a significant increase in the pulse peak power by 9.4×. These results represent the strongest temporal compression demonstrated to date on a complementary metal–oxide–semiconductor (CMOS) chip. In addition, we report the first demonstration of on-chip spectral compression, 3.0× spectral compression of 480 fs pulses, importantly while preserving the pulse energy. The strong compression achieved at low powers harnesses advanced on-chip device design, and the strong nonlinear properties of backend-CMOS compatible ultra-silicon-rich nitride, which possesses absence of two-photon absorption and 500× larger nonlinear parameter than in stoichiometric silicon nitride waveguides. The demonstrated work introduces an important new paradigm for spectro-temporal compression of optical pulses toward turn-key, on-chip integrated systems for all-optical pulse control.
KarMMa-RW: comparison of idecabtagene vicleucel with real-world outcomes in relapsed and refractory multiple myeloma
Authors: Jagannath Sundar , Lin Yi , Goldschmidt Hartmut , Reece Donna , Nooka Ajay , Senin Alicia , Rodriguez-Otero Paula , Powles Ray , Matsue Kosei , Shah Nina , Anderson Larry D. , Streetly Matthew , Wilson Kimberly , Le Hoa Van , Swern Arlene S. , Agarwal Amit , Siegel David S. 
Published: June 2021

AbstractPatients with relapsed and refractory multiple myeloma (RRMM) who are triple-class exposed (to an immunomodulatory agent, proteasome inhibitor, and anti-CD38 antibody) have limited treatment options and there is no standard of care. Idecabtagene vicleucel (ide-cel, bb2121), a BCMA-directed CAR T-cell therapy, demonstrated efficacy in triple-class exposed RRMM patients in the KarMMa trial (NCT03361748). In this retrospective study (KarMMa-RW), patient-level data from triple-class exposed RRMM patients were merged into a single data model and compared with KarMMa using trimmed stabilized inverse probability of treatment weighting. Endpoints included overall response rate (ORR; primary), rate of very good partial response or better (≥VGPR), progression-free survival (PFS), and overall survival (OS). Of 1949 real-world triple-class exposed RRMM patients, 190 received subsequent (index) line of therapy and met KarMMa eligibility criteria (Eligible RRMM cohort). With a median follow-up of 13.3 months in KarMMa and 10.2 months in Eligible RRMM, ORR, and ≥VGPR were significantly improved in KarMMa versus Eligible RRMM (ORR, 76.4% vs 32.2%; ≥VGPR, 57.9% vs 13.7%; both P < 0.0001) as were PFS (11.6 vs 3.5 months; P = 0.0004) and OS (20.2 vs 14.7 months; P = 0.0006). This study demonstrated that ide-cel significantly improved responses and survival compared with currently available therapies in triple-class exposed RRMM.
Comprehensive understanding of anchorage-independent survival and its implication in cancer metastasis
Authors: Deng Zhong , Wang Huixue , Liu Jinlong , Deng Yuan , Zhang Nu 
Published: June 2021

AbstractDetachment is the initial and critical step for cancer metastasis. Only the cells that survive from detachment can develop metastases. Following the disruption of cell–extracellular matrix (ECM) interactions, cells are exposed to a totally different chemical and mechanical environment. During which, cells inevitably suffer from multiple stresses, including loss of growth stimuli from ECM, altered mechanical force, cytoskeletal reorganization, reduced nutrient uptake, and increased reactive oxygen species generation. Here we review the impact of these stresses on the anchorage-independent survival and the underlying molecular signaling pathways. Furthermore, its implications in cancer metastasis and treatment are also discussed.
Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer
Authors: Zhang Xiaohui , Li Fangyuan , Zhou Yidong , Mao Feng , Lin Yan , Shen Songjie , Li Yuntao , Zhang Sheng , Sun Qiang 
Published: June 2021

AbstractLong noncoding ribonucleic acids (LncRNAs) have been found to be involved in the proliferation, apoptosis, invasion, migration, and other pathological processes of triple-negative breast cancer (TNBC). Expression of the lncRNA actin filament-associated protein 1 antisense RNA1 (AFAP1-AS1) has been found to be significantly higher in TNBC than in other subtypes or in normal tissue samples, but the specific mechanism by which AFAP1-AS1 affects the occurrence and development of TNBC is yet to be revealed. In this study, we used Cell Counting Kit-8 (CCK-8), colony formation, wound healing migration, Transwell invasion, and nude mouse xenograft assays to confirm the role of AFAP1-AS1 in the proliferation, migration of TNBC cells in vitro and in vivo. In addition, we performed bioinformatics analyses, reverse transcriptase quantitative polymerase chain reaction (RT-qPCR), western blot (WB), and dual-luciferase reporter assays (dual-LRA) to confirm interaction among AFAP1-AS1, micro-RNA 2110 (miR-2110), and Sp1 transcription factor (Sp1). We found that silencing AFAP1-AS1 and Sp1 or upregulating miR-2110 suppressed the proliferation, migration, and invasion of MDA–MB-231 and MDA–MB-468 cells in vitro as well as tumor growth in vivo. Mechanistically, the dual-LRA highlighted that miR-2110 was an inhibitory target of AFAP1-AS1, and that AFAP1-AS1 functioned as a miR-2110 sponge to increase Sp1 expression. AFAP1-AS1 silencing led to a reduction in Sp1 mRNA and protein levels, which could be reversed by joint transfection with miR-2110 inhibitor. Our findings demonstrated that AFAP1-AS1 could modulate the progression of breast cancer cells and affect tumorigenesis in mice by acting as a miR-2110 sponge, resulting in regulation of Sp1 expression. Therefore, AFAP1-AS1 could play a pivotal role in the treatment of TNBC.
Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder
Authors: Nishioka Masaki , Kazuno An-a , Nakamura Takumi , Sakai Naomi , Hayama Takashi , Fujii Kumiko , Matsuo Koji , Komori Atsuko , Ishiwata Mizuho , Watanabe Yoshinori , Oka Takashi , Matoba Nana , Kataoka Muneko , Alkanaq Ahmed N. , Hamanaka Kohei , Tsuboi Takashi , Sengoku Toru , Ogata Kazuhiro , Iwata Nakao , Ikeda Masashi , Matsumoto Naomichi , Kato Tadafumi , Takata Atsushi 
Published: June 2021

AbstractBipolar disorder is a severe mental illness characterized by recurrent manic and depressive episodes. To better understand its genetic architecture, we analyze ultra-rare de novo mutations in 354 trios with bipolar disorder. For germline de novo mutations, we find significant enrichment of loss-of-function mutations in constrained genes (corrected-P = 0.0410) and deleterious mutations in presynaptic active zone genes (FDR = 0.0415). An analysis integrating single-cell RNA-sequencing data identifies a subset of excitatory neurons preferentially expressing the genes hit by deleterious mutations, which are also characterized by high expression of developmental disorder genes. In the analysis of postzygotic mutations, we observe significant enrichment of deleterious ones in developmental disorder genes (P = 0.00135), including the SRCAP gene mutated in two unrelated probands. These data collectively indicate the contributions of both germline and postzygotic mutations to the risk of bipolar disorder, supporting the hypothesis that postzygotic mutations of developmental disorder genes may contribute to bipolar disorder.
Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers
Authors: Shah Ami , Ratkowski Madison , Rosa Alessandro , Feinstein Paul , Bozza Thomas 
Published: June 2021

AbstractOlfactory sensory neurons express a large family of odorant receptors (ORs) and a small family of trace amine-associated receptors (TAARs). While both families are subject to so-called singular expression (expression of one allele of one gene), the mechanisms underlying TAAR gene choice remain obscure. Here, we report the identification of two conserved sequence elements in the mouse TAAR cluster (T-elements) that are required for TAAR gene expression. We observed that cell-type-specific expression of a TAAR-derived transgene required either T-element. Moreover, deleting either element reduced or abolished expression of a subset of TAAR genes, while deleting both elements abolished olfactory expression of all TAARs in cis with the mutation. The T-elements exhibit several features of known OR enhancers but also contain highly conserved, unique sequence motifs. Our data demonstrate that TAAR gene expression requires two cooperative cis-acting enhancers and suggest that ORs and TAARs share similar mechanisms of singular expression.