bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Alterations and Their Correlation With the Survival of Glioblastoma Patients With Corpus Callosum Involvement
Authors: Cui Meng , Gao Xin , Chi Yihong , Zhang Meng , Lin Hepu , Chen Hewen , Sun Caihong , Ma Xiaodong 
Published: July 2021

Purpose: To explore molecular alterations and their correlation with the survival of patients with glioblastoma (GBM) with corpus callosum (CC) involvement (ccGBM).Methods: Electronic medical records were reviewed for glioma patients tested for molecular alterations and treated at our hospital between January 2016 and July 2020. ccGBM was compared to GBM without CC involvement (non-ccGBM) to identify differences in molecular alterations. Clinical outcomes and survival were compared between ccGBM and non-ccGBM patients, as well as among patients with ccGBM with different molecular alteration statuses. ccGBM was also compared to diffuse midline glioma (DMG) to clarify their correlation in molecular alterations, the progression-free survival (PFS), and overall survival (OS).Results: Thirty ccGBM and 88 non-ccGBM patients were included. PDGFRA amplification (PDGFRAamp, 33.3 vs. 9.1%, P = 0.004) and missense mutation (PDGFRAmut, 20.0 vs. 3.4%, P = 0.011) both had higher incidences in ccGBM than in non-ccGBM. PDGFRA alteration was associated with the occurrence of ccGBM (OR = 4.91 [95% CI: 1.55–15.52], P = 0.007). ccGBM with PDGFRAamp resulted in a shorter median PFS (8.6 vs. 13.5 months, P = 0.025) and OS (12.4 vs. 17.9 months, P = 0.022) than non-ccGBM with PDGFRAnon-amp. ccGBM with PDGFRAamp combined with PDGFRAmut (PDGFRAamp-mut) had a shorter median PFS (7.6 vs. 8.9 months, P = 0.022) and OS (9.6 vs. 17.8 months, P = 0.006) than non-ccGBM with wild-type PDGFRA and no amplification (PDGFRA-w, non-amp). Compared to ccGBM with PDGFRA-w, non-amp, ccGBM with PDGFRAamp and PDGFRAamp-mut both had a shorter median PFS and OS (P &lt; 0.05). The hazard ratios (HRs) of PDGFRAamp for PFS and OS in ccGBM were 3.08 (95% CI: 1.02–9.35, P = 0.047) and 5.07 (1.52–16.89, P = 0.008), respectively, and the HRs of PDGFRAamp-mut for PFS and OS were 13.16 (95% CI: 3.19–54.40, P &lt; 0.001) and 16.36 (2.66–100.70, P = 0.003). ccGBM may have similar incidences of PDGFRAamp or mut (PDGFRAamp/mut) as DMG, and they also had similar median PFS (10.9 vs. 9.0 months, P = 0.558) and OS (16.8 vs. 11.5 months, P = 0.510).Conclusion:PDGFRA alterations are significantly associated with the occurrence and poor prognosis of ccGBM. ccGBM with PDGFRAamp/mut may be classified as a single subtype of GBM that has a similar survival rate to DMG. PDGFR inhibitors may be a promising treatment method for ccGBM.
Dexamethasone Treatment Limits Efficacy of Radiation, but Does Not Interfere With Glioma Cell Death Induced by Tumor Treating Fields
Authors: Linder Benedikt , Schiesl Abigail , Voss Martin , Rödel Franz , Hehlgans Stephanie , Güllülü Ömer , Seifert Volker , Kögel Donat , Senft Christian , Dubinski Daniel 
Published: July 2021

PurposeDexamethasone (Dex) is the most common corticosteroid to treat edema in glioblastoma (GBM) patients. Recent studies identified the addition of Dex to radiation therapy (RT) to be associated with poor survival. Independently, Tumor Treating Fields (TTFields) provides a novel anti-cancer modality for patients with primary and recurrent GBM. Whether Dex influences the efficacy of TTFields, however, remains elusive.MethodsHuman GBM cell lines MZ54 and U251 were treated with RT or TTFields in combination with Dex and the effects on cell counts and cell death were determined via flow cytometry. We further performed a retrospective analysis of GBM patients with TTFields treatment +/- concomitant Dex and analysed its impact on progression-free (PFS) and overall survival (OS).ResultsThe addition of Dex significantly reduced the efficacy of RT in U251, but not in MZ54 cells. TTFields (200 kHz/250 kHz) induced massive cell death in both cell lines. Concomitant treatment of TTFields and Dex did not reduce the overall efficacy of TTFields. Further, in our retrospective clinical analysis, we found that the addition of Dex to TTFields therapy did not influence PFS nor OS.ConclusionOur translational investigation indicates that the efficacy of TTFields therapy in patients with GBM and GBM cell lines is not affected by the addition of Dex.
Prescription of Potentially Inappropriate Medication in Older Inpatients of an Internal Medicine Ward: Concordance and Overlap Among the EU(7)-PIM List and Beers and STOPP Criteria
Authors: Perpétuo Carla , Plácido Ana I. , Rodrigues Daniela , Aperta Jorge , Piñeiro-Lamas Maria , Figueiras Adolfo , Herdeiro Maria Teresa , Roque Fátima 
Published: July 2021

Background: Age-related comorbidities prone older adults to polypharmacy and to an increased risk of potentially inappropriate medication (PIM) use. This work aims to analyze the concordance and overlap among the EU(7)-PIM list, 2019 Beers criteria, and Screening Tool of Older Person’s Prescriptions (STOPP) version 2 criteria and also to analyze the prevalence of PIM.Methods: A retrospective cohort study was conducted on older inpatients of an internal medicine ward. Demographic, clinical, and pharmacological data were collected, during March 2020. After PIM identification by the EU(7)-PIM list, Beers criteria, and STOPP v2 criteria, the concordance and overlap between criteria were analyzed. A descriptive analysis was performed, and all the results with a p-value lower than 0.05 were considered statistically significant.Results: A total of 616 older patients were included in the study whose median age was 85 (Q1–Q3) (78–89) years. Most of the older patients were male (51.6%), and the median (Q1–Q3) number of days of hospitalization was 17 (13–22) days. According to the EU(7)-PIM list, Beers criteria, and STOPP criteria, 79.7, 92.0, and 76.5% of older adults, respectively, used at least one PIM. A poor concordance (&lt;63.4%) among criteria was observed. An association between PIM and the number of prescribed medicines was found in all applied criteria. Moreover, an association between the number of PIMs and diagnoses of endocrine, nutritional, and metabolic diseases, mental, behavioral, and neurodevelopmental disorders, and circulatory system diseases and days of hospitalization was observed according to Beers criteria, and that with diseases of the circulatory system and musculoskeletal system and connective tissue was observed according to STOPP criteria.Conclusion: Despite the poor concordance between the EU(7)-PIM list, 2019 Beers, and STOPP v2 criteria, this work highlights the need for more studies in inpatients to develop strategies to facilitate the identification of PIM to decrease the high prevalence of PIM in hospitalized patients. The poor concordance among criteria also highlights the need to develop new tools adapting the existing criteria to medical ward inpatients.
Oleanolic Acid Improves Obesity-Related Inflammation and Insulin Resistance by Regulating Macrophages Activation
Authors: Li Wanqing , Zeng Hongxiang , Xu Min , Huang Chenglong , Tao Linfen , Li Jun , Zhang Ting , Chen Hong , Xia Jing , Li Chunli , Li Xi 
Published: July 2021

The chronic low-grade inflammation of adipose tissues, primarily mediated by adipose tissue macrophages (ATMs), is the key pathogenic link between obesity and metabolic disorders. Oleanolic acid (OA) is a natural triterpenoid possessing anti-diabetic and anti-inflammation effects, but the machinery is poorly understood. This study investigated the detailed mechanisms of OA on adipose tissue inflammation in obese mice. C57BL/6J mice were fed with high-fat diet (HFD) for 12 weeks, then daily intragastric administrated with vehicle, 25 and 50 mg/kg OA for 4 weeks. Comparing with vehicle, OA administration in obese mice greatly improved insulin resistance, and reduced adipose tissue hypertrophy, ATM infiltration as well as the M1/M2 ratio. The pro-inflammatory markers were significantly down-regulated by OA in both adipose tissue of obese mice and RAW264.7 macrophages treated with interferon gamma/lipopolysaccharide (IFN-γ/LPS). Furthermore, it was found that OA suppressed activation of mitogen-activated protein kinase (MAPK) signaling and NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome through decreasing voltage dependent anion channels (VDAC) expression and reactive oxygen species (ROS) production. This is the first report that oleanolic acid exerts its benefits by affecting mitochondrial function and macrophage activation.
Lilium philadelphicum Flower as a Novel Source of Antimicrobial Agents: A Study of Bioactivity, Phytochemical Analysis, and Partial Identification of Antimicrobial Metabolites
Authors: Singh Shefali , Singh Vineeta , Alhazmi Alaa , Mishra Bhartendu Nath , Haque Shafiul , Sayyed R. Z. , Sunita Kumari 
Published: July 2021

The members of the Liliaceae family are considered an excellent source of biologically active compounds. However, work on antimicrobial potential and characterization of the bioactive fractions of the Lilium philadelphicum flower is limited and needs to be explored. The present study reports the antimicrobial potential of the bioactive fraction extracted from the flower of L. philadelphicum (red lily) and partial characterization of the bioactive compound(s). The antimicrobial activity was tested against nine different Gram-positive and Gram-negative bacterial strains. The minimum inhibitory concentration (MIC) values of methanolic extract of the L. philadelphicum flower against Acinetobacter bouvetii, Achromobacter xylosoxidans, Bacillus subtilis MTCC 121, Candida albicans MTCC 183, Klebsiella pneumoniae MTCC 3384, and Salmonella typhi MTCC 537 were 25, 50, 12.5, 50, 100, and 50 μg/mL, respectively. The phytochemical analysis of the extract revealed the presence of phenols, flavonoids, tannins, terpenoids, glycosides, coumarins, and quinones. The cytotoxicity of the partially purified compound against the HepG2 cell line using MTT assay demonstrated up to 90% cell viability with a bioactive compound concentration of 50 μg/mL. However, the increase in the bioactive compound’s concentration up to 1000 μg/mL resulted in nearly 80% cell viability. This minor decline in cell viability suggests the importance and suitability of the bioactive compound for therapeutic applications. Spectroscopic studies of the bioactive compound by UV-visible spectroscopy, FT-infrared spectroscopy, gas chromatography-mass spectrometry (GC-MS), as well as phytochemical analysis, suggested the presence of a terpenoid moiety, which may be responsible for the antimicrobial property of the L. philadelphicum flower.
Responsiveness of Criminal Law to Skimming Crimes in The Era of Industrial Revolution 4.0 (Four Point Zero)
Authors: Suryadi Ahmad 
Published: July 2021

This study aims to: 1)Analyze and understand the responsiveness of criminal law in entering the era of industrial revolution 4.0 (four point zero), 2)Enforcement of criminal law in cyber crime, criminal acts in cyber crime, criminal responsibility of cyber crime perpetrators. This research is normative-empirical research which is basically a merger between normative legal approach with the addition of empirical elements as the implementation of normative law in its action on every legal event that occurs in society. The results of this study show that cyber crime is a special crime. Cyber Crime has the intent as a crime in the realm of computer technology and internet networks as targets. The basis of law enforcement considerations in cyber crime is based on Law No. 11 of 2008 concerning Information and Electronic Transactions in the Act as amended into Law No. 19 of 2016 on Information and Electronic Transactions (ITE) on Information and Electronic Transactions. Criminal liability for perpetrators of cyber crime crimes always pay attention to the enactment of Law No. 11 of 2008 on Information and Electronic Transactions in as amended into Law No. 19 of 2016 on Information and Electronic Transactions (ITE) on Information and Electronic Transactions and pay attention to the methods of criminal law. In the process of law enforcement on cyber crime must always prioritize legal certainty as a form to provide protection and security in the process of transactions through the internet for the public at large.
La educación en la Constitución Política de 1991 y algunas realidades
Authors: Forero Hernández Derly Janeth 
Published: July 2021

El presente texto expone a modo general una explicación acerca de la constitucionalización del derecho educativo en Colombia, así como de algunas realidades que se están presentando respecto de la infraestructura y cobertura del servicio público a la educación.
Hubungan Faktor Fisik, Penyakit Komorbid, dan Faktor Psikis Terhadap Kualitas Hidup Lansia dengan Osteoartritis
Authors: Rasyidin Nur Laelatul , Julianti Hari Peni , Ngestiningsih Dwi , Purwoko Yosef 
Published: July 2021

ABSTRAK

LATAR BELAKANG: Osteoartritis merupakan penyebab disabilitas keempat di dunia pada tahun 2020. Pembatasan aktifitas fisik yang terjadi pada lansia dengan osteoartritis dapat mempengaruhi aspek sosial-ekonomi lansia sehingga menyebabkan penurunan health-related quality of life (HRQoL). Selain osteoartritis studi terbaru menunjukkan adanya hubungan antara riwayat hipertensi, diabetes, dan dukungan keluarga terhadap kualitas hidup lansia.
TUJUAN: Menganalisis hubungan faktor fisik, penyakit komorbid, dan faktor psikis terhadap kualitas hidup lansia dengan osteoartritis lutut.
METODE: Penelitian ini merupakan penelitian analitik observasional dengan rancangan cross sectional. Sampel adalah penderita OA lutut yang menjalani terapi di Rumah Sakit William Booth Semarang dan Rumah Sakit Nasional Diponegoro yang memenuhi kriteria inklusi penelitian. Subjek penelitian sebanyak 61 responden dipilih melalui consecutive sampling. Uji analisis dilakukan dengan metode Chi-square dan regresi logistik dengan nilai p dianggap bermakna apabila p<0.05. Instrumen yang digunakan pada penelitian ini adalah kuesioner karaktersitik demografi, VAS, family APGAR, dan OPQOL-35.
HASIL: Terdapat hubungan yang signifikan pada penilaian tingkat nyeri dan fungsi keluarga terhadap kualitas hidup lansia dengan OA lutut (p=0.003 dan p=0,042). Penilaian faktor fisik lainnya yang terdiri atas jenis kelamin (p=0.637), lama sakit (p=0.2), dan derajat radiologi (p=0.532) serta faktor komorbid yang terdiri atas hipertensi (p=0.37) dan diabetes (p=0.663) menujukkan hubungan yang yang tidak signifikan terhadap kualitas hidup lansia dengan OA lutut. Faktor dominan yang memengaruhi kualitas hidup lansia dengan OA lutut adalah tingkat nyeri (p=0.022) dengan nilai OR= 14.1.
SIMPULAN: Faktor yang memengaruhi kualitas hidup lansia dengan OA lutut adalah tingkat nyeri dan fungsi keluarga.

Kunci: OA lutut, Kualitas Hidup, Lansia
Perbedaan Skor OSDI Pre dan Post Senam "PERMATA-KU" pada Computer Vision Syndrome
Authors: Uyun Fuadah , Rahmi Fifin Luthfia , Saubig Arnila Novitasari , Julianti Hari Peni 
Published: July 2021

ABSTRAK
Latar Belakang: Computer Vision Syndrome (CVS) merupakan kumpulan masalah pada mata dan penglihatan akibat dari penggunaan komputer, telepon seluler, tablet, dan e-reader yang berkepanjangan. Dry eye (mata kering) merupakan salah satu gejala yang biasa muncul pada CVS. Pada penelitian ini dilakukan senam ‘PERMATA-KU’ (Pelihara Mata–Kendorkan Bahu) sebagai senam tambahan untuk mengurangi gejala dry eye pada CVS.
Tujuan: Membuktikan adanya perbaikan skor OSDI (Ocular Surface Disease Index) sebelum dan setelah senam “PERMATA-KU” pada CVS.
Metode: Jenis penelitian adalah penelitian ekperimen kuasi dengan Pre-Post with Control Design. Subjek penelitian adalah mahasiswa Fakultas Kedokteran UNDIP yang mengalami CVS dan memenuhi kriteria inklusi dan eksklusi yang dikelompokkan menjadi kelompok perlakuan dan kelompok kontrol secara acak. Kelompok perlakuan diberikan intervensi edukasi ergonomis penggunaan komputer dan senam PERMATA-KU selama 14 hari. Kelompok kontrol diberikan intervensi edukasi ergonomis penggunaan komputer. Skor OSDI diukur sebelum dan setelah intervensi menggunakan kuesioner Ocular Surface Disease Index.
Hasil: Subjek penelitian berjumlah 32 orang dengan 16 orang pada kelompok perlakuan dan 16 orang pada kelompok kontrol. Satu orang pada kelompok kontrol dan satu orang pada kelompok perlakuan drop out karena tidak dapat menyelesaikan prosedur penelitian sehingga hanya 30 subjek penelitian yang dianalisis. Skor OSDI setelah intervensi pada kelompok perlakuan mengalami penurunan signifikan (p<0,05). Skor OSDI setelah intervensi pada kelompok perlakuan lebih baik daripada kelompok kontrol (p<0,05). Perbaikan skor OSDI pada kelompok perlakuan lebih baik dibandingkan dengan kelompok kontrol tetapi tidak signifikan (p=0,595).
Kesimpulan: Senam PERMATA-KU yang dilakukan selama 14 hari dapat memperbaiki skor OSDI pada Compter Vision Syndrome.

Kata Kunci: Compter Vision Syndrome (CVS), Ocular Surface Disease Index (OSDI), dry eye, Senam PERMATA-KU
Perbedaan Kadar Gula Darah Sewaktu pada Pasien Skizofrenia yang Mendapat Terapi Antipsikotik Generasi Kedua Selama kurang dari Empat Bulan dan lebih dari Empat Bulan
Authors: Rahayu Rani , Fulyani Faizah , Jusup Innawati , Fitrikasari Alifiati 
Published: July 2021

ABSTRAK

LATAR BELAKANG : Skizofrenia merupakan gangguan mental dengan mortalitas dua sampai tiga kali lipat lebih tinggi dibandingkan populasi umum. Antispikotik generasi kedua merupakan salah satu terapi untuk skizofenia, namun memiliki efek samping gangguan metabolik yang lebih tinggi dibandingkan antipsikotik golongan pertama, seperti peningkatan kadar gula darah.

TUJUAN : Mengetahui perbedaan kadar gula darah sewaktu pasien skizofrenia yang mendapatkan terapi antipsikotik generasi kedua selama kurang dari empat bulan dan lebih dari empat bulan.

METODE : Penelitian ini merupakan penelitian observasional analitik dengan desain potong lintang. Sampel adalah data rekam medis 67 pasien skizofrenia di RSJD Amino Gondohutomo Semarang yang memenuhi kriteria inklusi. Subjek dibagi menjadi dua kelompok yaitu yang mendapatkan terapi kurang dari 4 bulan dan yang mendapatkan terapi selama lebih dari 4 bulan. Uji statistik menggunakan uji Mann Whitney untuk mengetahui perbedaan antara kedua kelompok.
HASIL : Kadar gula darah sewaktu pada kelompok yang mendapat terapi antipsikotik generasi kedua selama kurang dari empat bulan lebih rendah (116 mg/dl) dibandingkan dengan yang mendapatkan terapi lebih dari empat bulan (118 mg/dl). Meskipun demikian, perbedaan tersebut tidak bermakna secara statistik (p>0.05).

KESIMPULAN : Tidak terdapat perbedaan kadar gula darah sewaktu pada pasien skizofrenia yang mendapatkan terapi antipsikotik generasi kedua kurang dari empat bulan dan lebih dari empat bulan.

Kata Kunci : skizofrenia, antipsikotik, gula darah sewaktu
POLA PEMBERIAN ANTIBIOTIK DI ERA PANDEMI COVID-19 (STUDI KASUS DI RUMAH SAKIT NASIONAL DIPONEGORO)
Authors: Putra Dominikus Evano , Pramudo Setyo Gundi , Arkhaesi Nahwa , Retnoningrum Dwi 
Published: July 2021

Latar Belakang: Penggunaan antibiotik yang tidak tepat dapat meningkatkan kejadian resistensi antibiotik yang pada akhirnya meningkatkan morbiditas, mortalitas, dan biaya kesehatan. WHO telah merekomendasikan untuk dilakukan kajian rasionalitas penggunaan antibiotik dalam rangka mengatasi masalah resistensi antibiotik.
Tujuan: Menganalisis kualitas dan kuantitas penggunaan antibiotik di instalasi rawat inap Rumah Sakit Nasional Diponegoro (RSND).
Metode: Penilaian kualitas dan kuantitas penggunaan antibiotik dilakukan berdasarkan DDD/100 pasien–hari dan kriteria van der Meer–Gyssens. Penelitian dilakukan secara retrospektif pada 86 rekam medis pasien yang didapatkan dengan metode consecutive sampling.
Hasil: Terdapat 141 peresepan antibiotik dalam 86 rekam medis. Azithromycin, levofloxacin, dan ceftriaxone merupakan antibiotik terbanyak yang digunakan dengan nilai DDD/100 pasien–hari 48,12; 44,01; dan 21,13. Berdasarkan kriteria Gyssens, 35,4% penggunaan antibiotik dengan bijak, 51,1% penggunaan antibiotik dengan tidak bijak, dan 13,5% tidak ada indikasi penggunaan antibiotik. Berdasarkan tipe terapi didapatkan ADE 89,4% dan ADET 10,6%.
Kesimpulan: Secara kuantitas, antibiotik yang paling banyak digunakan adalah azithromycin. Secara kualitas, 35,4% antibiotik digunakan dengan bijak berdasarkan kriteria Gyssens.

Kata kunci: DDD/100 pasien-hari; kriteria Gyssens; penggunaan antibiotik; penyakit dalam
Cognitive rehabilitation effectiveness for severe to moderate traumatic brain injury: case series
Authors: Hamami Ahlam Ibrahim 
Published: July 2021

Objective: This case series study aimed to investigate the effectiveness of a holistic approach of a computer-assisted and traditional neuropsychological rehabilitation program in improving some cognitive functions in patients who sustained a traumatic brain injury (TBI).
Methods: The case series study followed a single-case design, with an A-B-A-B design and was conducted in the rehabilitation center at King Fahad Medical City-Saudi Arabia between Aug 2015 and March 2016. Participants comprised 5 males with moderate-to-severe TBI and persistent cognitive impairments. The computerized model included known software programs for cognitive rehabilitation to improve this rehabilitation process. The program period was six weeks for each case, all focusing on executive functions, memory, and attention.
Results: three out of the five cases improved remarkably in their attentional, executive, and related memory functions; with one showing moderate improvement and the five-case showing little improvement.
Conclusion: The holistic approach of the neuropsychological rehabilitation program is effective for some TBI cases in improving their cognitive and psychosocial functioning, alongside vocational outcomes, as reported in the follow-up interviews of the patients and their families. More research is required to contribute to the current literature and for the study's findings to be further analyzed for these interventions.
Start-Up Business Camp TDA Wilayah Jakarta
Authors: Samiono Bambang Eko , Nurlatifah Hanny 
Published: July 2021

<p><em>Komunitas Bisnis Tangan Di Atas (TDA) adalah komunitas wirausaha terbesar di Indonesia, wadah bergabungnya para wirausahawan di Indonesia</em><em>. </em><em>Beberapa program banyak dilakukan untuk meningkatkan capacity building anggota TDA tersebut</em><em>.</em><em> </em><em>N</em><em>amun</em><em>,</em><em> sebagian besar program masih belum terstuktur dan tersegmen untuk level tertentu. Sehingga hal ini menyulitkan untuk pebisnis pemula untuk mendapatkan pelatihan dalam satu paket yang tepat. Selain itu</em><em>,</em><em> terlihat bahwa banyak sekali pebisnis pemula mengikuti berbagai macam pelatihan secara berulang karena masih belum paham bagaimana menerapkan materi pelatihan yang didapat. Tim pengabdian masyarakat yang telah lama bekerjasama dengan divisi edukasi Internal TDA Jakarta Selatan dan Jakarta Timur bekerjasama sebagai kontribusi untuk memberikan solusi terhadap permasalahan yang dihadapi mitra yaitu berupa 1) Memberikan Program Workshop series dalam bentuk Camp, 2) Penyediaan mentor yang sesuai dengan bidangnya yang mampu memberikan pembekalan secara praktis dan sistematis serta 3) Memberikan materi praktis berupa lembar kerja sebagai template untuk memulai bisnis sehingga bisa di gunakan secara praktis. Pelatihan Start Up Business Camp ini di jalankan dalam 4 sesi selama 2 kali pertemuan dengan 10 orang peserta bisnis pemula dari TDA Jaksel dan Jaktim. Di</em><em> </em><em>akhir pelatihan diperoleh evaluasi adanya tingkat kepuasan terhadap peaksanaan pelatihan ini sebesar 96%.</em></p><p><strong>Kata kunci:</strong><em> </em><em>Bisnis, Wirausaha, Pendampingan</em><em>, </em><em>S</em><em>tart</em><em> </em><em>up, </em><em>Pelatihan</em></p>