bluuebunny/crossref_metadata_2025_split huggingface dataset:
Covid-19 Salgınının Türkiye’de Tıp Fakültesi Olan Devlet Üniversiteleri Giderleri Üzerine Etkileri İçin Ampirik Bir Analiz
Authors: YAMAN Adem , ATILGAN SARIDOĞAN Ayşe 
Published: December 2021

Tüm dünyada olduğu gibi Türkiye’de de Covid-19 salgını, sağlık, ekonomi ve sosyal alanlarda, önemli olumsuz etkilere yol açmıştır. Diğer yandan, 2020’nin başlarında etkisini hissettiren Covid-19 salgını, ülkelere ve sektörlere göre farklı düzeylerde olumsuz etkilere yol açmaktadır. Türkiye’de genelde pandemi hastaneleri, özelde ise, tıp fakültesi olan devlet üniversiteleri, Covid-19 Salgının yönetilmesinde ve olumsuz etkilerinin azaltılmasında son derece büyük önem arz etmektedir. Bu bağlamda, bu çalışmanın temel amacı, Türkiye’de tıp fakültesi olan devlet üniversiteleri giderleri üzerinde, Covid-19 salgının etkilerini istatistiki olarak incelemektir. İstatistiksel analiz sonuçlarına göre, Türkiye’de tıp fakültesi olan devlet üniversiteleri giderleri, hem aynı dönemde tıp fakültesi olmayan devlet üniversiteleri giderlerine göre artış göstermiştir, hem de 2020 yılında, 2019 yılına göre istatistiksel olarak anlamlı bir artış göstermiştir. Sonuç olarak, Covid-19 Salgının ile mücadelede hayati öneme sahip olan tıp fakültesine sahip üniversitelerin giderlerinin finansmanın etkili bir şekilde yönetilmesi, salgın başta olmak üzere, diğer hastalıkların yönetimi açısından da son derece büyük önem arz etmektedir.
Anahtar kelimeler: Covid-19 Salgını, Devlet Üniversiteleri, Gider
Mechanical Characteristics and Failure Modes of Low-Strength Rock Samples with Dissimilar Fissure Dip Angles
Authors: Wang Y L , Liu D S , Li K , Hu X M , Chen D 
Published: December 2021

The mechanical characteristics and failure modes of low-strength rock sample with various fissure dip angles were investigated by conventional uniaxial compression test and three-dimensional (3D) crack reconstruction. The results indicated that compared with high-strength rock masses, cracks had different influences on the low-strength rock mass mechanical deformation features. Thereinto, the dip angle of fissures can cause post-peak failure stage of stress-strain curve change from swift decline to multi-step down, showing obvious ductility deformation and failure characteristics. Peak strength and elastic modulus owned an anti-S-shaped growth tendency with the growth of fissure dip angle, which was positively correlated and greatest subtle to the fissure dip angle α < 21° and α > 66.5°. The axial peak strain reduced first and enlarged rapidly with growing fissure dip angle, suggesting a V-shaped change trend. Increasing the fissure dip angle will change the sample failure mode, experienced complete tensile failure to tensile-shear composite failure, and ultimately to typical shear failure. Also, the crack start angle decreased with enlarging fissure dip angle, larger than that the high-strength rock mass fissure dip angle. The above research findings can complement and improve the study of fissured rock masses.
Nutritional biomarkers and machine learning for personalized nutrition applications and health optimization
Authors: Panagoulias Dimitrios P. , Sotiropoulos Dionisios N. , Tsihrintzis George A. 
Published: December 2021

The doctrine of the “one size fits all” approach in the field of disease diagnosis and patient management is being replaced by a more per patient approach known as “personalized medicine”. In this spirit, biomarkers are key variables in the research and development of new methods for prognostic and classification model training based on advances in the field of artificial intelligence [1, 2, 3]. Metabolomics refers to the systematic study of the unique chemical fingerprints that cellular processes leave behind. The metabolic profile of a person can provide a snapshot of cell physiology and, by extension, metabolomics provide a direct “functional reading of the physiological state” of an organism. Via employing machine learning methodologies, a general evaluation chart of nutritional biomarkers is formulated and an optimised prediction method for body to mass index is investigated with the aim to discover dietary patterns.
Correlation of Prolonged Total Ischemic Time with Body Mass Index in Kidney Transplant: A Single Center Report
Authors: Eriawan Agung Nugroho  , Erwin Wibowo  , Aryani Prathita Amanda 
Published: December 2021

Background: Chronic kidney disease (CKD) is a rising health concern worldwide, especially in Indonesia. The treatment of choice for end-stage renal disease is Kidney Transplantation.1 Numerous studies showed that prolonged total ischemic ischemic time may cause hypoxia of the graft tissue and increased risk of ischemia and reperfusion injury (IRI) and delayed graft function (DGF).2 Body mass index of kidney transplant recipients may cause prolonged duration of the procedure, as well as prolonged total ischemic time. This study aimed to determine the correlation between prolonged total ischemic time with body mass index.
Method: This was an observational and cross-sectional analysis at Kariadi General Hospital Semarang involving patients who underwent kidney transplantation from January 2016 to December 2019. The total ischemic time was recorded intraoperatively. The Body Mass Index data were provided by medical records. The program used to statistically analyze the data was SPSS 23.0, and Spearman was used for hypothesis testing.
Result: This study included 25 kidney transplant recipients. The mean total ischemic time was 43,27 ± 6,63 minutes. There was a significant positive correlation between prolonged ischemic time and body mass index (r= 0,506 ; p= 0,010).
Conclusion: Prolonged total ischemic time was positively correlated with increased body mass index and these results are statistically significant.
The Effect of the Covid-19 Free Operation Path Protocol on the Incidence of Lung Complications in Postoperative Elective Patients at dr. Moewardi Hospital Surakarta
Authors: Aktama Galih , Henky Agung Nugroho  , Muhammad David Perdana Putra  
Published: December 2021

The pandemic that began in late 2019, COVID-19, affects all patients, including cancer patients. Patients with cancer that continues to spread and there is no other effective alternative treatment must undergo surgery so that cancer does not get worse. Given this problem, many health care centers have developed a protocol system in the form of a COVID-19-free surgical route. This study is a retrospective cohort study comparing the incidence of pulmonary complications in patients undergoing elective cancer surgery at dr. Moewardi Surakarta before and during the COVID-19 pandemic. The study sample was adult patients aged ≥ 18 years which underwent elective surgical procedures with the aim of curative cancer starting before COVID-19 (March 2019-February 2020) until the time the COVID-19 pandemic emerged (March 2020 - February 2021). The data obtained were 768 patients. Of these patients, 384 were classified as having a COVID19-free operation route during the pandemic, and 384 others underwent elective surgery in the pre-pandemic period. Based on the Chi-Square test, a p-value of 0.850 was obtained (P>0.05) which shows that there is significant difference between cases of pulmonary complications in surgical patients before and after the pandemic who were carried out through the COVID-19-free protocol route. In conclusion, there is no significant change in effect of the covid-19 free operation path protocol on the incidence of lung complications in postoperative elective patients at dr. Moewardi Hospital Surakarta, although this patented and mandatory protocol can reduce cancer patients’ morbidity and mortality who undergoing elective surgery during a pandemic.
The Ethanolic Extract of Annonaceous sp. to Inhibit Vascular Endothelial Growth Factor (VEGF) as Anticancer Modalities
Authors: Muhartono Muhartono , Asep Sukohar  , Khairun Nisa  , Ratna Dewi Puspita Sari  , Suharyani  , Arli Suryawinata  
Published: December 2021

Introduction: Cancer has become a major public health problem worldwide, with breast cancer is the most common cancer among women and one of the most important causes of death among them. Management of breast cancer have some adverse effects, with many factorx=s shiouln be considered to ordered the therapy. Use of chemotherapy will suppress cell proliferation and trigger apoptosis, but it cannot just focus on cancer cells only, but also would affected on other cells and cause.
Objective: This study aim to analyze the inhibition effect of the Annonanceous sp. ethanolic extract to Vascular Endothelial Growth Factor (VEGF) on MCF-7 cells line
Material and Methods: This study is an analytic experimental study used Randomized Complete Block Design (RCBD) with three repetitions. The extract was dissolved in 1 ml of DMSO with a concentration of 0.1%. Furthermore, dilution was made with a dose of 0 µg / ml (K); 25 µg / ml (P1); 50 µg / ml (P2); 100 µg / ml (P3); 200 µg / ml (P4). MCF-7 cells line were cultured used RPMI 1640 Medium with 80 – 90% confluent. The ethanolic extract of Annonaceous sp. were exposed to MCF-7 cells for 48 hours. Analyze of VEGF level use ELISA Methods with λ=405 nm.
Results: The results of ELISA analyze shows that the ethanolic extract of Annonaceous sp. have potential effect to decreased of VEGF expression on sample with treatment on some concentration (p< 0,05).
Conclusion: The ethanolic extract of Annonaceous sp. has shows the potential effect to decreased of VEGF level on MCF-7 cells line
The Effectivity of Supplementation Artemisia vulgaris for Adenocarcinoma Mammae Chemotherapy to Reduce CD 34 and Tumor Massa Diameter (Study in C3H Mice Given Adriamycin - Cyclophosphamide Chemotherapy)
Authors: Saputro Bayu Teguh , Selamat Budijitno  
Published: December 2021

Introduction: Breast cancer is still a major health problem in the world. In the case of breast cancer, surgery is the main treatment option besides chemotherapy, radiation, and immunotherapy such as Artemisia vulgaris (AV). AV is cytotoxic selectively acts as a supplement to breast adenocarcinoma chemotherapy given the Adriamycin-Cyclophosphamide regimen, to improve chemotherapy response.The study was aimed to proving AV extract enhances the chemotherapy response in C3H mice with adenocarcinoma mammae given Adriamycin-Cyclophosphamide Chemotherapy.
Method: This study used Post test only control group design on 24 females C3H mice that were randomly selected and divided into four groups: group K (control), P1 (chemotherapy), P2 (extract), and P3 (combination). Adenocarcinoma mammae comes from the inoculation of donor mice. Chemotherapy of Adriamycin 60 mg / m 2 and Cyclophosphamide 600 mg / m 2 were given in two cycles. AV 13 mg (0.2 ml) was given once daily orally. CD34 were evaluated by imunohistochemical staining and tumor mass diameter were counted by calipers.
Result: The microvascular density CD34 and tumor mass diameter were obtained in groups of K, P1, P2, P3 respectively 60.76 ± 1.5; 39.70 ± 2.00; 57.10 ± 1.29; 35.26 ± 2.06 and 12.52 ± 1.49; 6.20 + 1.04; 9,94 + 1.21; 3.94 + 0.76. Statistical analysis showed significant differences in CD34 between groups K vs P1, P2, P3 (p = 0.001, p = 0.014, p = 0.001), P1 vs P2 and P3 (p = 0.001, p = 0.033) and P2 (P = 0.001). Tumor mass diameter between groups K vs P1, P2, P3 (p=0.001; p=0.014; p=0,001), P1 with P2 (p= 0.001) P1 with P3 (p = 0.033) and P2 with P3 (p = 0.001). Correlation analysis between CD34 with tumor mass diameter was found to have significant correlation (p = 0.001 and r = 0.932).
Conclusion: Artemisia vulgaris is a potential to reduce angiogenesis in terms of decreasing the microvascular density CD34 and tumor mass diameter of adenocarcinoma mammae of C3H mice treated with Adriamycin-Cyclophosphamide chemotherapy and can improve the effectivity.
Jugular Vein Aneurysm, When We Have to Do Surgery?
Authors: Amalia Rizki , Nugroho Johanes , Dewi Ivana Purnama 
Published: December 2021

Introduction: The most common lesions of jugular vein dilatation are aneurysms and ectasia. A jugular vein aneurysm is less common compare to an arterial aneurysm in adults. Because of the rare incidence, treatment guidelines primarily associated with the timing of surgery are not clearly established. Proper treatment can reduce patient complaints without excessive intervention.
Case report: A 54 years old woman complained of swelling in the right neck that started three years ago and cephalgia for two years. From CT angiography, we obtained a jugular vein dilatation of 2.3 cm. During periodic evaluation from ultrasonography doppler, there is no increase in the size of the jugular vein.
Conclusion: Jugular vein aneurysm presenting in adults is an infrequent phenomenon. It is a benign condition, and conservative observation is advised. It should be operated only if symptomatic or progressive enlarging. A periodic examination must be done to evaluate the size of the jugular vein before a surgical decision
Laparoscopic Davydov Procedure for Creation of Neovagina in MRKH Syndrome
Authors: Krisna Ratih , Rizky Agustria  
Published: December 2021

Introduction: The Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a condition in which there is an absence of the uterus and the upper part (2/3) of the vagina. Women with MRKH syndrome show normal development of secondary sexual characteristics and a normal 46, XX karyotype. MRKH syndrome is a common cause of primary amenorrhea. Ultrasonography examination confirms kidneys, presence of the ovaries, and absence of uterus. Treatment should include a multidisciplinary approach to create a functional vagina. One of the procedures is laparoscopic Davydov vaginoplasty.
Aim: To report MRKH syndrome case treated with laparoscopic Davydov vaginoplasty.
Method: Ms. A, 21 years old, P0A0, came to FER clinic Moh. Hoesin Hospital Palembang with complaint, never had menstruation, the patient admitted her breast, and her pubic had growth. She wants to get married in the next six months. From the US result, there was non visualized uterus, genital band (+), and both ovaries within normal limit ~ MRKH Syndrome. Karyotype Examination: 46, XX. Patient was diagnosed with primary amenorrhea caused by MRKH syndrome and was planned for neovagina (Davydov Procedure).
Result: A woman 21-year-old, P0A0, was diagnosed with primary amenorrhea caused by MRKH syndrome. The Davydov procedure was done to create a neovagina. Intraoperative, after protrusion of the wood mold as a marker shown, an incision is made to the left and right side so that the mold penetrates the abdominal cavity, then the mold is pulled into the vaginal canal slowly. The anterior and posterior peritoneal layers are drawn into the vaginal canal. The anterior and posterior peritoneal layers were withdrawn with an ovum clamp and then interrupted suture. The anterior and posterior peritoneal layers were sutured in a circular method to form a vaginal cuff. The vaginal wall is sutured (interrupted) to hold mold fixed.
Conclusion: MRKH syndrome is a disorder that occurs in females and mainly affects the reproductive system. This condition causes the vagina and the uterus to be underdeveloped or even absent at birth. Patients with diagnosed MRKH syndrome require interdisciplinary care. Davydov procedure is a laparoscopically-assisted technique, which has an advantage over traditional approaches. It has shorter operating time, lower intraoperative complications, shorter hospital stay, and no external scars. Postoperatively, sexual function is similar to women without gynecological disorders.
Factors Associated with The Incidence of Infection in Tracheostomy Stoma at Mohammad Hoesin Hospital
Authors: Lisa Apri Yanti  , Oktriyani Nelly , Erial Bahar  
Published: December 2021

Introduction: Tracheostomy is a surgery to open the trachea to allow air to enter the airway. Tracheostomy cannot be separated from possible complications. Tracheostomy stoma infection is one of the complications of post-tracheostomy that occurs due to the activity of several bacteria. Many factros can cause the incidence of tracheostomy stoma infection.
Objective: The aim of this study is to determine the factors associated with the incidence of tracheostomy stoma infection.
Methods: Observational study with cross-sectional design. Data collection was carried out using medical record data on 71 subjects who underwent tracheostomy tube replacement from july 2019 to November 2020.
Results: From 71 subjects, it was found that the subjects who had tracheostomy stoma infection were 54.9%. The results of bivariate analysis showed that age (p=0.031), comorbidities (p=0.009), the type of tracheostomy tube (p=0.015), the use of antiseptic in tracheostomy dressing (p=0.020), tracheostomy tube care (p=0.013), and the interval of changing the tracheostomy tube (p=0.041) are the significant factors. The results of multivariate analysis showed that tracheostomy tube care and the interval of changing the tracheostomy tube had a significant effect on tracheostomy stoma infection. Tracheostomy tube care has a risk of 9.362 times to experience infection with CI95%(1.535-57.086) and the interval of changing the tracheostomy tube has a risk of 10.669 with CI95% (1.074-105.985).
Conclusion: There is a significant relationship between age, comorbidities, type of tracheostomy tube, the use of antiseptic in tracheosotmy dressing, tracheosotmy tube care, and interval of changing the tracheostomy tube with the incidence of tracheostomy stoma infection.
Primary Squamous Cell Carcinoma Thyroid with Regional Recurrence
Authors: Akhbar Nugroho , Benny Issakh  
Published: December 2021

Background. Primary squamous cell carcinoma (PSCC) of the thyroid is a very aggressive malignancy with a poor prognosis. There is no consensus for the management of primary squamous cell carcinoma (PSCC) of the thyroid, and this is based on rare cases in which the frequency of occurrence is less than 1% of thyroid malignancies. How squamous cell carcinoma originates in the thyroid gland is an interesting topic to discuss, because the thyroid gland does not have a squamous cell epithelium.
Case Presentation. A 43-year-old man was admitted to the DR Kariadi Hospital with complaints of a lump on the right neck. In June 2020, the patient complained of a lump in the right neck area with a diameter of about 1x1x1 cm, no pain. Ultrasound of the colli at the regional hospital showed the impression of multiple lymphadenopathy of the right colli level 2-5, and there were cystic nodules with solid parts in the right and left lobes of the thyroid suspected of being benign. An adenectomy operation was performed at a regional hospital and the impression of metastatic squamous undifferentiated carcinoma was obtained.
Conclusion. The management of thyroid PSCC is a multimodality therapy, namely surgery, chemotherapy and radiation.
REFLEXÕES PRELIMINARES SOBRE A UNIDADE TEMATÍCA ESPORTES NA BASE NACIONAL COMUM CURRICULAR
Authors: Marques Rodrigo Gonçalves Vieira , Zaghi Flavio Henrique Lara da Silveira , Diana Fernando , Alves Fernando Donizete 
Published: December 2021

A importância de compreender a intencionalidade do ensino dos esportes enquanto conteúdo na Base Nacional Comum Curricular (BNCC) é o objetivo do estudo. Sendo a pesquisa qualitativa de caráter exploratório. A análise ocorreu com o texto introdutório da unidade temática esportes e suas subdivisões que são os objetos de conhecimento e habilidades propostas como expectativas de aprendizagem. A BNCC considera o esporte e sua diversidade cultural em seu texto introdutório. Porém, ao aprofundar para as subdivisões dos esportes, os objetos de conhecimento possuem exclusivamente como critério de organização elementos da lógica interna/organização, sendo as habilidades propostas para os esportes predominância da lógica interna/organização interna, sem propor alterações pedagógicas para ampliar a participação inclusiva e democrática dos estudantes no processo de ensino dos esportes. Apenas quatro de 13 habilidades relacionadas aos esportes consideraram elementos da lógica externa, como doping, conflitos e mídia. Possibilitando refletir sobre os esportes e suas intencionalidades/interesses na escola.
A EDUCAÇÃO FÍSICA E UM COTIDIANO ESCOLAR: DESAFIOS E REINVENÇÕES EM TEMPOS PANDÊMICOS
Authors: Ricardo da Silva Cintia de Assis , Bilitario Luciana Antunes , Holanda Francisco Dionleno Rodrigues 
Published: December 2021

O presente texto é um breve relato de experiências de três docentes do Colégio Pedro II, no Campus Realengo I, na cidade do Rio de Janeiro, no ano letivo de 2020/2021. As experiências foram realizadas com turmas dos anos iniciais do ensino fundamental (primeiro ao quinto ano) e trazem pistas acerca do trabalho docente atravessado pelo momento histórico em que uma pandemia por Covid-19 assola a população mundial. O texto se apresenta a partir de narrativas que fazem tecituras com noções de infâncias, experiências lúdicas, escuta, relações dialógicas e reinvenções docentes para uma Educação Física em tempos remotos, em que o distanciamento social seguro impede a presença no chão da escola, nos convocando a atividades síncronas e assíncronas com crianças. Traz desdobramentos do projeto Corpo: memórias, história e movimentos, a partir das memórias e das narrativas orais, escritas, imagéticas trazidas pelas crianças e problematizadas pelos temas da cultura corporal.
Reconstructing 1200 years of Hydroclimate Variability in the Southern Margins of the Arabian Desert: Insights From a Paleo-Lake in Southern Yemen
Authors: Parth Shah , Russell James , Waldmann Nicolas 
Published: December 2021

The climate of the Arabian Desert is not well documented during the past two millennia due to the scarcity of continuous and well-dated terrestrial archives in the region. Reliable interpretation from the climatic records from this region are pivotal for identifying periodicities of inter-annual to multi-decadal variability and trends driven by shifts in position of the Intertropical Convergence Zone (ITCZ) and the strength of the monsoons. A high-resolution multiproxy approach is presented for a ∼3.3 m composite core, GBW, from a karst lake located in Ghayl ba Wazir, southern Yemen. Sedimentary proxies, including particle size distribution, coupled with magnetic susceptibility (MS) and geochemistry (XRF), provide a comprehensive picture of sediment depositional changes that may be linked to climate and environmental variability over the southern Arabian Desert. The chronology of the GBW core is provided by five radiocarbon (14C) dates from terrestrial macrofossils (wood and twigs) extracted from sediment samples and indicates the core extends to ∼900 CE. Our data indicates generally wetter conditions from 930 to 1400 CE corresponding to the “Medieval climate anomaly (MCA)” followed by arid phases during 1,410–1700 CE coinciding with the “Little Ice Age (LIA)”. Evidence for a drier LIA include high authigenic calcium precipitation [Ca/(Al + Fe + Ti)], decreased TOC/TIC values, and gypsum precipitation, whereas the wetter MCA is characterized by higher detrital element ratios (Ti/Al, K/Al, Rb/Sr), and increased TOC/TIC and deposition of finer sediments (EM1). Furthermore, end-member mixing analyses (EMMA) derived from the grain-size distribution (EM2 and EM3) corroborates the deposition of coarser silt sediment through wind erosion and production of carbonate sand during the LIA concurrently with low lake levels under generally dry conditions. Aridity during the LIA is consistent with evidence and theory for weakened boreal summer monsoons during intervals of northern hemisphere cooling.