bluuebunny/crossref_metadata_2025_split huggingface dataset:
AS SIGNIFICAÇÕES DE ALUNOS COM DIFICULDADES DE APRENDIZAGEM SOBRE ENSINAR E APRENDER NA ESCOLA
Authors: Miyabe Denise , Toscano Carlos 
Published: January 2021

O presente estudo discute os resultados preliminares de uma pesquisa em andamento. Esta pesquisa foi realizada em uma turma do 3º ano do ensino fundamental de uma escola pública do município de Londrina/PR e teve como objetivo revelar e compreender as significações dos alunos produzidas no e sobre o processo de ensino-aprendizagem. Para tanto, fez-se uso de observação direta em sala de aula e de entrevistas para coletar dados e sua análise, com base na perspectiva histórico-cultural, pautou-se nas concepções de linguagem de Vigotski e Bakhtin e nas análises feitas por Lahire e Charlot sobre o sucesso e o fracasso escolar. Como resultado, constatou-se que as significações das crianças a respeito de si e do ensinar e aprender são construídas e ressignificadas no próprio processo de ensino-aprendizagem e os fatores intervenientes nesse processo foram: a mediação pedagógica, as condições de trabalho e a mobilização dos alunos.
The influence of yeast extract and jasmonic acid on phenolic acids content of in vitro hairy root cultures of Orthosiphon aristatus
Authors: Smetanska Iryna , Tonkha Oksana , Patyka Tetjana , Hunaefi Dase , Mamdouh Diaa , Patyka Mуkola , Bukin Anatolyi , Mushtruk Mikhailo , Slobodyanyuk Natalia , Omelian Alina 
Published: January 2021

Phenolic acids represent a big group of plant secondary metabolites that can be used as food additives, nutraceuticals, and pharmaceuticals. Obtaining phenolic acids from the plant in vitro cultures provide an attractive alternative to produce high-value plant-derived products. The impact of yeast extract and jasmonic acid on the induction of defense responses and consequently the production of phenolic acids in vitro hairy root cultures of O. aristatus have been investigated. Treatment of O. aristatus cultures with jasmonic acid caused accumulation of 12.98 mg.g-1 DW of phenolic acids, elicitation with yeast extract resulted in the highest amount of phenolic acids, particularly in 17.99 mg.g-1 DW as compared to 4.03 mg.g-1 DW for the non-treated cultures. Individual phenolic acids showed a different response to elicitation. Particularly rosmarinic acid content on the control plot reached 2.89 mg.g-1 DW, while after the treatment with jasmonic acid is increased to 10.84 mg.g-1 DW and after yeast application, it was 14.31 mg.g-1 DW. Also, caffeic acid content increased until 0.75 and 2.01 mg.g-1 DW after application of jasmonic acid and yeast extract, while at the control plot its concentration was 0.58 mg.g-1 DW. Application of yeast extract influenced synthesis of phenolic acids in vitro cultures of O. aristatus stronger as jasmonic acid treatment.
Chain Reduction via Substitution: Evidence from Mayan
Authors: Mendes Gesoel , Ranero Rodrigo 
Published: January 2021

We argue that deletion is not the only way that chain links created by A′-movement can be affected at PF. Chain links can also be substituted by a morpheme. This substitution delivers a linearizable output (in a manner parallel to deletion), creating overt “traces” on the surface. We demonstrate the virtues of our proposal through the empirical lens of adjunct extraction in two Mayan languages of the K’ichean branch: K’iche’ and Kaqchikel. In these languages, extraction of low adjuncts triggers the appearance of a verbal enclitic wi. The distribution of the enclitic upon long distance extraction shows that it must be analyzed as a surface reflex of substitution of a chain link. Our proposal provides evidence that movement proceeds successive cyclically and has two additional theoretical consequences: (i) C0 must be a phase head (contra den Dikken 2009; 2017), (ii) v0 cannot be a phase head (in line with Keine 2017).
Samenvatting expertmeeting CCRA over HR 14 december 2018: omgang in het kader van een ondertoezichtstelling
Authors: Laterveer B. 
Published: January 2021

Samenvatting expertmeeting CCRA over HR 14 december 2018: omgang in het kader van een ondertoezichtstelling
Op dinsdag 10 december 2019 heeft het ‘Centre for Children’s Rights Amsterdam’ (CCRA) een bijeenkomst georganiseerd met verschillende experts uit de praktijk om te spreken over de gevolgen van de uitspraak van de Hoge Raad van 14 december 2018 (ECLI:NL:HR:2018:2321) voor de (rechts)praktijk, welke beslissing de gemoederen blijft bezighouden. Wat de bijeenkomst onder meer bijzonder maakte, was het feit dat raadsheer mr. C.E. (Edgar) Du Perron van de Hoge Raad (op persoonlijke titel) aanwezig was. Hij maakte deel uit van de samenstelling die de beslissing heeft gegeven.
Checklist and a new species of Lippia (Verbenaceae) from the Diamantina Plateau, Minas Gerais, Brazil
Authors: Cardoso Pedro Henrique , Menini Neto Luiz , Trovó Marcelo , Salimena Fátima Regina Gonçalves 
Published: January 2021

The Diamantina Plateau is located in the central region of the Espinhaço Range, in the State of Minas Gerais, which is dominated by campo rupestre formations. We describe a new species of Lippia L., endemic to the Diamantina Plateau, and provide an annotated checklist and identification key for the 17 species of the genus occurring in the area. Lippia raoniana P.H.Cardoso & Salimena sp. nov. is mainly distinguished by its ovate leaves with adaxial and abaxial surfaces densely covered by sessile glandular trichomes, and drupaceous fruits with two pyrenes. It is known only from two populations, and thus can be provisionally considered as Critically Endangered. Details on the species’ ecology, as well as a comparison with morphologically similar species, a distribution map, and field photographs, are provided. In this work, we also present pictures of the 17 species in their habitats, and we hope that these illustrations will help in the identification and conservation of these taxa.
Recent Advances and Developments in Hyphenated Techniques and their Applications
Authors: Wilson Jero Victor , Karthikeyan L. V. , Parida Shubham Kumar , Nath Bikash Chandra , Jeyaprakash M. R. 
Published: January 2021

Background: A hyphenated technique is blend or coupling of two distinctive analytical methods like chromatographic and spectral methods with appropriate interface.
Objective: This article describes about the various hyphenated techniques, a brief note on their instrumentation and working principles that are used in the current setup of industries. Like-wise their remarkable improvement and efficiency over the past decade. The techniques like single quadrupole inductively coupled mass spectrometry (ICP-Q-MS), ICP- Triple quadrupole mass spectrometry (ICP-QQQ), Liquid chromatography-Two -dimensional Gas chromatography mass spectrometry (LC-GCXGC-MS/MS), Two dimensional liquid chromatography (2D-LC), Fourier transform near infrared spectroscopy (FT-NIR) ,etc. are considered as recent improvements in this trend.
Conclusion: This development in the hyphenated techniques supports in different scientific fields, biomedical research, food and drug analysis. In addition to this improvement produced remarkable dimensional changes in the natural product analysis and elemental specifications.
Sustainable Dough‐Based Gel Electrolytes for Aqueous Energy Storage Devices
Authors: Wang Rui , Yao Minjie , Huang Shuo , Tian Jinlei , Niu Zhiqiang 
Published: January 2021

AbstractPolymer gel electrolytes are usually utilized in various energy storage devices due to their advantages of excellent ionic conductivity and outstanding mechanical properties. However, they are often not biodegradable and lose their flexibility and electrochemical performance during the dehydration/hydration process. Herein, sustainable dough‐based gel electrolytes with high biosafety and environmental friendliness are developed. In the dough electrolytes, gluten molecules connect with each other through disulfide bonds to construct gluten network and water that contains abundant ions adheres on it to achieve a continuous ion transport pathway. Therefore, the dough electrolytes possess outstanding mechanical properties and excellent ionic conductivities. More impressively, they also exhibit the ability to recover their electrochemical and mechanical performance after dehydration/hydration cycles as well as the self‐adhering, degradable, and edible behaviors. As a proof of concept, the dough electrolytes are used in supercapacitors and zinc‐ion batteries. The resultant devices display comparable electrochemical performance in comparison with the counterparts with polymer gel electrolytes. Furthermore, the multiple functions of dough electrolytes are also integrated into the supercapacitors and zinc‐ion batteries devices. This work provides a promising route to design highly sustainable gel electrolytes for different aqueous energy storage devices.
3D Particle‐Free Printing of Biocompatible Conductive Hydrogel Platforms for Neuron Growth and Electrophysiological Recording
Authors: Wang Chen , Rubakhin Stanislav S. , Enright Michael J. , Sweedler Jonathan V. , Nuzzo Ralph G. 
Published: January 2021

AbstractElectrically conductive 3D periodic microscaffolds are fabricated using a particle‐free direct ink writing approach for use as neuronal growth and electrophysiological recording platforms. A poly (2‐hydroxyethyl methacrylate)/pyrrole ink, followed by chemical in situ polymerization of pyrrole, enables hydrogel printing through nozzles as small as 1 µm. These conductive hydrogels can pattern complex 2D and 3D structures and have good biocompatibility with test cell cultures (≈94.5% viability after 7 days). Hydrogel arrays promote extensive neurite outgrowth of cultured Aplysia californica pedal ganglion neurons. This platform allows extracellular electrophysiological recording of steady‐state and stimulated electrical neuronal activities. In summation, this 3D conductive ink printing process enables the preparation of biocompatible and micron‐sized structures to create customized in vitro electrophysiological recording platforms.
Precision in Thermal Therapy: Clinical Requirements and Solutions from Nanotechnology
Authors: Gschwend Pascal M. , Hintze Justin M. , Herrmann Inge K. , Pratsinis Sotiris E. , Starsich Fabian H. L. 
Published: January 2021

AbstractThe heating of diseased tissue as a therapeutic measure has gained increased clinical attention, mostly due to its target‐specificity that minimizes side effects. However, to ensure a successful therapy, heating has to be homogeneous and highly localized, as well as, within a certain temperature range. Therefore, precise control over thermal treatments is a clinical prerequisite to minimize treatment and safety margins. Although this requirement is mentioned frequently, past research has focused predominantly on improving thermometry resolution and heating efficiency through tedious material optimization. Here, current clinical applications of thermal therapy with their challenges are first highlighted, especially with respect to treatment control and margins. Thereafter, it is quantitatively shown that clinically available thermometry fulfills the requirements and future research should focus on achieving better temperature control instead. With nanotechnology, novel strategies based on self‐limiting nanoparticle systems and particle‐based thermometers with active feed‐back control have also become available and are discussed. All of these approaches are systematically compared and analyzed with respect to their clinical applicability. The extent to which control over thermal therapy is necessary is also discussed alongside a presentation of the existing methods which fulfill the set requirements for clinical success and what issues remain to be tackled by research in the near future.
Naphthalene Monoimide Derivative Ameliorates Amyloid Burden and Cognitive Decline in a Transgenic Mouse Model of Alzheimer's Disease
Authors: Samanta Sourav , Rajasekhar Kolla , Ramesh Madhu , Murugan Natarajan Arul , Alam Shadab , Shah Devanshi , Clement James Premdas , Govindaraju Thimmaiah 
Published: January 2021

AbstractAlzheimer's disease (AD) is a major neurodegenerative disorder and the leading cause of dementia worldwide. Predominantly, misfolding and aggregation of amyloid‐β (Aβ) peptides associated with multifaceted toxicity is the neuropathological hallmark of AD pathogenesis and, thus the primary therapeutic target to ameliorate neuronal toxicity and cognitive deficits. Herein, the design, synthesis, and evaluation of small molecule inhibitors with naphthalene monoimide scaffold to ameliorate in vitro and in vivo amyloid induced neurotoxicity are reported. The detailed studies establish TGR63 as the lead candidate to rescue neuronal cells from amyloid toxicity. The in silico studies show the disruption of salt bridges and intermolecular hydrogen bonding interactions within Aβ42 fibrils by the interaction of TGR63, causing destabilization of Aβ42 assembly. Remarkably, TGR63 treatment shows a significant reduction in cortical and hippocampal amyloid burden in the progressive stages of APP/PS1 AD mice brain. Various behavioral tests demonstrate rescued cognitive deficits. The excellent biocompatibility, blood–brain barrier permeability, and therapeutic efficacy to reduce the amyloid burden make TGR63 a promising candidate for the treatment of AD.
On‐Chip Biogenesis of Circulating NK Cell‐Derived Exosomes in Non‐Small Cell Lung Cancer Exhibits Antitumoral Activity
Authors: Kang Yoon‐Tae , Niu Zeqi , Hadlock Thomas , Purcell Emma , Lo Ting‐Wen , Zeinali Mina , Owen Sarah , Keshamouni Venkateshwar G. , Reddy Rishindra , Ramnath Nithya , Nagrath Sunitha 
Published: January 2021

AbstractAs the recognition between natural killer (NK) cells and cancer cells does not require antigen presentation, NK cells are being actively studied for use in adoptive cell therapies in the rapidly evolving armamentarium of cancer immunotherapy. In addition to utilizing NK cells, recent studies have shown that exosomes derived from NK cells also exhibit antitumor properties. Furthermore, these NK cell‐derived exosomes exhibit higher stability, greater modification potentials and less immunogenicity compared to NK cells. Therefore, technologies that allow highly sensitive and specific isolation of NK cells and NK cell‐derived exosomes can enable personalized NK‐mediated cancer therapeutics in the future. Here, a novel microfluidic system to collect patient‐specific NK cells and on‐chip biogenesis of NK‐exosomes is proposed. In a small cohort of non‐small cell lung cancer (NSCLC) patients, both NK cells and circulating tumor cells (CTCs) were isolated, and it is found NSCLC patients have high numbers of NK and NK‐exosomes compared with healthy donors, and these concentrations show a trend of positive and negative correlations with bloodborne CTC numbers, respectively. It is further demonstrated that the NK‐exosomes harvested from NK‐graphene oxide chip exhibit cytotoxic effect on CTCs. This versatile system is expected to be used for patient‐specific NK‐based immunotherapies along with CTCs for potential prognostic/diagnostic applications.
A Tunable Resonant Circuit Based on Graphene Quantum Capacitor
Authors: Zhang Danlu , Zhang Le , Feng Xuemeng , Han Tianyi , Gao Ruiyan , Chen Shouheng , Wang Ning , Chen Xiaolong 
Published: January 2021

AbstractGraphene has been widely investigated for electronic applications due to its outstanding physical properties, such as high carrier mobility, electrically tunable physical properties, and excellent compatibility with silicon technology. Here, taking advantage of the gate‐tunable physical properties of graphene, an LC resonant circuit based on graphene quantum capacitors is demonstrated, in which the resonant frequency can be electrically tuned from 1.45 to 1.73 MHz. At the same time, a quality factor ranging from 65 to 25 is achieved. The investigation suggests graphene is a promising material for signal processing applications.
Recent advances in analytical techniques for high throughput experimentation
Authors: Vervoort Nico , Goossens Karel , Baeten Mattijs , Chen Qinghao 
Published: January 2021

AbstractHigh throughput experimentation is a growing and evolving field that allows to execute dozens to several thousands of experiments per day with relatively limited resources. Through miniaturization, typically a high degree of automation and the use of digital data tools, many parallel reactions or experiments at a time can be run in such workflows. High throughput experimentation also requires fast analytical techniques capable of generating critically important analytical data in line with the increased rate of experimentation. As traditional techniques usually do not deliver the speed required, some unique approaches are required to enable workflows to function as designed. This review covers the recent developments (2019‐2020) in this field and was intended to give a comprehensive overview of the current “state‐of‐the‐art.”
Galaxy: Dark matter connection in cosmology
Authors: Fromenteau Sébastien , Vargas Magaña Mariana , Toledo Ortiz Marcos Iram , Tapia Benavides Brenda Izamar , Rodriguez Otero Matias , Sandoval Ramos Beatriz Miroslava 
Published: January 2021

AbstractWe present a new approach to improve the forward modeling of reconstruction method for the Baryonic Acoustic Oscillations study. We use probability information from the Halo Occupation Distribution (HOD) function of a given type of galaxies in order to enhance the estimation of the local density field of the dark matter. We couple the HOD information to the Conditional Luminosity Function of red type galaxies to exemplify the possibility to enhance the connection between dark matter and a well‐established tracer as Luminous Red Galaxies (LRGs). However, the main purpose is to enhance this connection for more complicated tracers as Emission Line Galaxies (ELGs) and quasars (QSOs).
Vom Handwerk zur individualisierten Serienfertigung
Authors: Mark Peter , Lanza Gisela , Lordick Daniel , Albers Albert , König Markus , Borrmann Andre , Stempniewski Lothar , Forman Patrick , Frey Alex Maximilian , Renz Robert , Manny Agemar 
Published: January 2021

AbstractBauen im Regen, eine katastrophale Vorstellung, doch Praxis auf Baustellen. Es bringt Ungenauigkeit, behindert den Einsatz moderner Hochleistungswerkstoffe und kostet Zeit, da Störungen im Bauprozess oft umständliche Rückläufe in den Planungsprozess bedeuten. Dennoch gilt der handwerklich geprägte Bauprozess als unvermeidlich, da jedes Bauwerk individuell und in Handarbeit vor Ort zu erstellen ist. Tatsächlich? Das von der Deutschen Forschungsgemeinschaft eingerichtete Schwerpunktprogramm „Adaptive Modulbauweisen mit Fließfertigungsmethoden“ setzt auf einen gänzlich neuen Ansatz. Baustrukturen werden in ähnliche modulare Betonfertigteile zerlegt, in Serienfertigung mit Fließprinzip vorgefertigt, in ihrer Qualität gesichert und auf der Baustelle nur noch zusammengefügt. Die Bauzeiten reduzieren sich auf wenige Tage oder Wochen. Vergleichbar einem Puzzle aus vielen Teilen, bleibt die Einzigartigkeit des Tragwerks erhalten. Es gilt: „Individualität im Großen – Ähnlichkeit im Kleinen“. Der Beitrag zeigt Ansätze zur Modularisierung, Produktionskonzepte und verknüpfende digitale Modelle. Durch die ortsfeste Vorfertigung in Serie entstehen hohe Produktionsgeschwindigkeiten und schlanke, ressourceneffiziente Module, die zu Tragwerken mit geringen Maßabweichungen assembliert werden. Eine durchgängige Digitalisierung sichert die Qualität aller Einzelschritte. Sie reicht von der Fertigung über den Zusammenbau bis in die Nutzungszeit des Tragwerks. Es entsteht ein verschwendungsarmer, ressourceneffizienter Gesamtprozess.
Clinical applications of a brief experimental analysis for problem behavior: Analysis of treatment effects and durability
Authors: Schmidt Jonathan D. , Goetzel Amanda L. , Rooker Griffin , Falligant John Michael , Beard Lisa 
Published: January 2021

AbstractThe brief experimental analysis (BEA) is an empirical method for comparing multiple academic interventions in a short amount of time and predicting intervention effects in subsequent extended evaluations. This study extended the BEA literature by evaluating its utility for identifying effective interventions for decreasing problem behavior and increasing compliance for two individuals diagnosed with autism spectrum disorder and intellectual disability who engaged in escape‐maintained problem behavior. Across individuals, four treatment arrangements were compared to a baseline‐control condition: noncontingent reinforcement (NCR) with food, NCR with toys, differential reinforcement of other behaviors (DRO) with food, and DRO with toys. Using an alternating treatment embedded within a withdrawal design, conditions from the BEA associated with the lowest rates of problem behavior and the highest rates of adaptive behavior (i.e., compliance) were further evaluated during schedule thinning. For both individuals, the two most effective interventions from the BEA maintained effects during extended application and schedule thinning. These findings extend the utility of the BEA to identify durable interventions for decreasing problem behavior and increasing adaptive behavior.
EMT‐associated microRNAs and their roles in cancer stemness and drug resistance
Authors: Pan Guangtao , Liu Yuhan , Shang Luorui , Zhou Fangyuan , Yang Shenglan 
Published: January 2021

AbstractEpithelial‐to‐mesenchymal transition (EMT) is implicated in a wide array of malignant behaviors of cancers, including proliferation, invasion, and metastasis. Most notably, previou studies have indicated that both cancer stem‐like properties and drug resistance were associated with EMT. Furthermore, microRNAs (miRNAs) play a pivotal role in the regulation of EMT phenotype, as a result, some miRNAs impact cancer stemness and drug resistance. Therefore, understanding the relationship between EMT‐associated miRNAs and cancer stemness/drug resistance is beneficial to both basic research and clinical treatment. In this review, we preliminarily looked into the various roles that the EMT‐associated miRNAs play in the stem‐like nature of malignant cells. Then, we reviewed the interaction between EMT‐associated miRNAs and the drug‐resistant complex signaling pathways of multiple cancers including lung cancer, gastric cancer, gynecologic cancer, breast cancer, liver cancer, colorectal cancer, pancreatic cancer, esophageal cancer, and nasopharyngeal cancer. We finally discussed the relationship between EMT, cancer stemness, and drug resistance, as well as looked forward to the potential applications of miRNA therapy for malignant tumors.
Tunable Synthesis of Hierarchical Yolk/Double‐Shelled SiOx@TiO2@C Nanospheres for High‐Performance Lithium‐Ion Batteries
Authors: Gong Qinghua , Wang Haiqing , Song Wenhua , Sun Bin , Cao Pei , Gu Shaonan , Sun Xuefeng , Zhou Guowei 
Published: January 2021

AbstractInvited for the cover of this issue is Qinghua Gong, Guowei Zhou, and co‐workers at Qilu University of Technology. The dial represents the etching time of SiOx yolk in NaOH solution and the brightness of the Chinese red lantern represents the electrochemical performance of the composites. Read the full text of the article at 10.1002/chem.202003246.