bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Efficiency and Safety Outcomes of Virtual Care for Oncology Patients During the COVID-19 Pandemic
Authors: Hsiehchen David , Muquith Maishara , Haque Waqas , Espinoza Magdalena , Yopp Adam , Beg Muhammad S. 
Published: June 2021

PURPOSE: Telehealth has been an integral response to the COVID-19 pandemic. However, no studies to date have examined the utility and safety of telehealth for oncology patients undergoing systemic treatments. Concerns of the adequacy of virtual patient assessments for oncology patients include the risk and high acuity of illness and complications while on treatment. METHODS: We assessed metrics related to clinical efficiency and treatment safety after propensity matching of newly referred patients starting systemic therapy where care was in large part replaced by telehealth between March and May 2020, and 206 newly referred patients from a similar time period in 2019 where all encounters were in-person visits. RESULTS: Patient-initiated telephone encounters that capture care or effort outside of visits, time to staging imaging, and time to therapy initiation were not significantly different between cohorts. Similarly, 3 month all-cause or cancer-specific emergency department presentations and hospitalizations, and treatment delays were not significantly different between cohorts. There were substantial savings in travel time with virtual care, with an average of 211.4 minutes saved per patient over a 3-month interval. CONCLUSION: Our results indicate that replacement of in-person care with virtual care in oncology does not lead to worse efficiency or outcomes. Given the increased barriers to patients seeking oncology care during the pandemic, our study indicates that telehealth efforts may be safely intensified. These findings also have implications for the continual use of virtual care in oncology beyond the pandemic.
Process Optimization for the Continuous Production of a Gastroretentive Dosage Form Based on Melt Foaming
Authors: Haimhoffer Ádám , Vasvári Gábor , Trencsényi György , Béresová Monika , Budai István , Czomba Zsuzsa , Rusznyák Ágnes , Váradi Judit , Bácskay Ildikó , Ujhelyi Zoltán , Fehér Pálma , Vecsernyés Miklós , Fenyvesi Ferenc 
Published: June 2021

AbstractSeveral drugs have poor oral bioavailability due to low or incomplete absorption which is affected by various effects as pH, motility of GI, and enzyme activity. The gastroretentive drug delivery systems are able to deal with these problems by prolonging the gastric residence time, while increasing the therapeutic efficacy of drugs. Previously, we developed a novel technology to foam hot and molten dispersions on atmospheric pressure by a batch-type in-house apparatus. Our aim was to upgrade this technology by a new continuous lab-scale apparatus and confirm that our formulations are gastroretentive. At first, we designed and built the apparatus and continuous production was optimized using a Box–Behnken experimental design. Then, we formulated barium sulfate-loaded samples with the optimal production parameters, which was suitable for in vivo imaging analysis. In vitro study proved the low density, namely 507 mg/cm3, and the microCT record showed high porosity with 40 μm average size of bubbles in the molten suspension. The BaSO4-loaded samples showed hard structure at room temperature and during the wetting test, the complete wetting was detected after 120 min. During the in vivo study, the X-ray taken showed the retention of the formulation in the rat stomach after 2 h. We can conclude that with our device low-density floating formulations were prepared with prolonged gastric residence time. This study provides a promising platform for marketed active ingredients with low bioavailability.
Differential Perioperative Outcomes in Patients With Obstructive Sleep Apnea, Obesity, or a Combination of Both Undergoing Open Colectomy: A Population-Based Observational Study
Authors: Stundner Ottokar , Zubizarreta Nicole , Mazumdar Madhu , Memtsoudis Stavros G. , Wilson Lauren A. , Ladenhauf Hannah N. , Poeran Jashvant 
Published: June 2021

BACKGROUND:
An increasing body of evidence demonstrates an association between obstructive sleep apnea (OSA) and adverse perioperative outcomes. However, large-scale data on open colectomies are lacking. Moreover, the interaction of obesity with OSA is unknown. This study examines the impact of OSA, obesity, or a combination of both, on perioperative complications in patients undergoing open colectomy. We hypothesized that while both obesity and OSA individually increase the likelihood for perioperative complications, the overlap of the 2 conditions is associated with the highest risk.

METHODS:
Patients undergoing open colectomies were identified using the national Premier Healthcare claims-based Database (2006–2016; n = 340,047). Multilevel multivariable models and relative excess risk due to interaction (RERI) analysis quantified the impact of OSA, obesity, or both on length and cost of hospitalization, respiratory and cardiac complications, intensive care unit (ICU) admission, mechanical ventilation, and inhospital mortality.

RESULTS:
Nine thousand twenty-eight (2.7%) patients had both OSA and obesity diagnoses; 10,137 (3.0%) had OSA without obesity; and 33,692 (9.9%) had obesity without OSA. Although there were overlapping confidence intervals in the binary outcomes, the risk increase was found highest for OSA with obesity, intermediate for obesity without OSA, and lowest for OSA without obesity. The strongest effects were seen for respiratory complications: odds ratio (OR), 2.41 (2.28–2.56), OR, 1.40 (1.31–1.49), and OR, 1.50 (1.45–1.56), for OSA with obesity, OSA without obesity, and obesity without OSA, respectively (all P < .0001). RERI analysis revealed a supraadditive effect of 0.51 (95% confidence interval [CI], 0.34–0.68) for respiratory complications, 0.11 (−0.04 to 0.26) for cardiac complications, 0.30 (0.14–0.45) for ICU utilization, 0.34 (0.21–0.47) for mechanical ventilation utilization, and 0.26 (0.15–0.37) for mortality in patients with both OSA and obesity, compared to the sum of the conditions’ individual risks. Inhospital mortality was significantly higher in patients with both OSA and obesity (OR [CI], 1.21 [1.07–1.38]) but not in the other groups.

CONCLUSIONS:
Both OSA and obesity are individually associated with adverse perioperative outcomes, with a supraadditive effect if both OSA and obesity are present. Interventions, screening, and perioperative precautionary measures should be tailored to the respective risk profile. Moreover, both conditions appear to be underreported compared to the general population, highlighting the need for stringent perioperative screening, documentation, and reporting.
Living In/difference; or, How to Imagine Ambivalent Networks
Authors: Albrecht Carina , Chun Wendy Hui Kyong , Kurgan Laura 
Published: June 2021

AbstractIn a 1954 essay Paul Lazarsfeld and Robert K. Merton coined the term homophily to describe similarity-based friendship. They based their findings on friendship patterns among neighbors in a biracial housing project in the United States, using a combined quantitative and qualitative, empirical and speculative analysis of social processes. Since then homophily has become a guiding principle for network science: it is simply presumed that similarity breeds connection. But the unpublished study by Merton, Patricia S. West, and Marie Jahoda, which grounds Lazarsfeld and Merton’s analysis, and the Merton and Bureau of Applied Social Research’s archive reveal a more complex picture. This article engages with the data traces in the archive to reimagine what enabled the residents of the studied housing project to live in difference, as neighbors. The reanimation of this archive reveals the often counterintuitive characteristic of our imagined networks: they are about removal, not addition. It also opens up new imagined possibilities for a digital future beyond the hatred of the different and online echo chambers.
Chimeric human opsins as optogenetic light sensitisers
Authors: Hickey Doron G. , Davies Wayne I. L. , Hughes Steven , Rodgers Jessica , Thavanesan Navamayooran , MacLaren Robert E. , Hankins Mark W. 
Published: June 2021

ABSTRACT
Human opsin-based photopigments have great potential as light-sensitisers, but their requirement for phototransduction cascade-specific second messenger proteins may restrict their functionality in non-native cell types. In this study, eight chimeric human opsins were generated consisting of a backbone of either a rhodopsin (RHO) or long-wavelength-sensitive (LWS) opsin and intracellular domains from Gq/11-coupled human melanopsin. Rhodopsin/melanopsin chimeric opsins coupled to both Gi and Gq/11 pathways. Greater substitution of the intracellular surface with corresponding melanopsin domains generally showed greater Gq/11 activity with a decrease in Gi activation. Unlike melanopsin, rhodopsin and rhodopsin/melanopsin chimeras were dependent upon exogenous chromophore to function. By contrast, wild-type LWS opsin and LWS opsin/melanopsin chimeras showed only weak Gi activation in response to light, whilst Gq/11 pathway activation was not detected. Immunocytochemistry (ICC) demonstrated that chimeric opsins with more intracellular domains of melanopsin were less likely to be trafficked to the plasma membrane. This study demonstrates the importance of Gα coupling efficiency to the speed of cellular responses and created human opsins with a unique combination of properties to expand the range of customised optogenetic biotools for basic research and translational therapies.
Frequency-scanned microresonator soliton comb with tracking of the frequency of all comb modes
Authors: Kuse Naoya , Navickaite Gabriele , Geiselmann Michael , Yasui Takeshi , Minoshima Kaoru 
Published: June 2021

Rapid and large scanning of a dissipative Kerr-microresonator soliton comb with characterization of all comb modes along with the separation of the comb modes is imperative for the emerging applications of frequency-scanned soliton combs. However, the scan speed is limited by the gain of feedback systems, and measurement of the frequency shift of all comb modes has not been demonstrated. To overcome the limitation of the feedback, we incorporate feedback with feedforward. With an additional gain of

>

40

d
B

by a feedforward signal, a dissipative Kerr-microresonator soliton comb is scanned by 70 GHz in

500

µ

s

, 50 GHz in

125

µ

s

, and 25 GHz in

50

µ

s

(= 500 THz/s). Furthermore, we propose and demonstrate a method to measure the frequency shift of all comb modes, in which an imbalanced Mach–Zehnder interferometer with two outputs with different wavelengths is used. Because of the two degrees of freedom of optical frequency combs, the measurement at two different wavelengths enables estimation of the frequency shift of all comb modes.
Optical modulator based on a silicon-ITO grating embedded rib structure with a tunable group delay
Authors: Rajput Swati , Kaushik Vishal , Singh Lalit , Srivastava Sulabh , Kumar Mukesh 
Published: June 2021

An optical modulator based on an engineered silicon-indium tin oxide (Si-ITO) structure is proposed with a tunable group delay. A large group delay is reported by slowing down the light in a Si-ITO grating embedded rib structure. Optical modulation and a tunable group delay are realized by utilizing the electrically tunable permittivity of ITO in the engineered waveguide. The extinction ratio over 8 dB for a 10 µm long device and the modulation efficiency around 12 V-µm are reported for a wide wavelength from 1530 to 1570 nm. The resulting modulation efficiency and the extinction ratio show a significant improvement as compared to conventional modulators based on rib waveguides. We also report around 82 psec electrical tuning in the group delay for a wide wavelength range. This concept is promising in view of realizing tunable delay lines, along with slow light modulators with a reduced device footprint and low energy dissipation.
The prevalence of depressive disorder and its association in Thai cervical cancer patients
Authors: Karawekpanyawong Nuntaporn , Kaewkitikul Kewalee , Maneeton Benchalak , Maneeton Narong , Siriaree Sitthicha 
Published: June 2021

Purpose
The purpose of this study is to examine the prevalence, associated factors and quality of life associated with depressive disorder in cervical cancer patients.

Patients and methods
This cross-sectional study was carried out in a gynecologic oncology clinic of a university hospital in Northern Thailand from October 2018 to August 2019. Two-hundred cervical cancer patients were screened for depressive disorder using the nine-item Patient Health Questionnaire (PHQ-9), and psychiatrists interviewed eligible patients to confirm diagnoses. We measured the quality of life using questionnaires from the European Organisation for the Research and Treatment of Cancer: Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and Cervical Cancer Module 24 (EORTC QLQ-Cx24). Associated factors, including comorbidity, fatigue, and pain, were collected using the Charlson Comorbidity Index (CCI), the eleven-item Chalder Fatigue Scale (CFQ 11), and the visual analog scale (VAS) for pain, respectively.

Results
Twenty-seven (13.5%) cervical cancer patients were diagnosed with depressive disorder by psychiatrists according to the DSM-5. Depressive disorder was related to a worse quality of life in these patients. A binary logistic regression analysis revealed that depressive disorder among these patients was linked with these factors: high fatigue score (aOR: 1.35; CI: 1.18–1.53), high pain score (aOR: 1.25; CI: 1.02–1.54), no perception of social support, (aOR: 3.12; CI: 1.11–8.81), and no previous surgical treatment for cervical cancer (aOR: 2.99; CI: 1.08–8.29).

Conclusion
The depressive disorder prevalence was 13.5% in Northern Thai cervical cancer patients. In this demographic, cervical cancer patients—who reported high fatigue or pain scores, did not perceive social support, or had no previous cervical cancer surgery- were more likely to have depressive disorder.
Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis
Authors: Kathamuthu Gokul Raj , Moideen Kadar , Sridhar Rathinam , Baskaran Dhanaraj , Babu Subash 
Published: June 2021

Background
Neutrophils are important for host innate immune defense and mediate inflammatory responses. Pulmonary tuberculosis (PTB) is associated with increased neutrophil granular protein (NGP) levels in the circulation. However, the systemic levels of neutrophil granular proteins were not examined in tuberculous lymphadenitis (TBL) disease.

Methods
We measured the systemic levels of NGP (myeloperoxidase [MPO], elastase and proteinase 3 [PRTN3]) in TBL and compared them to latent tuberculosis (LTB) and healthy control (HC) individuals. We also measured the pre-treatment (Pre-T) and post-treatment (Post-T) systemic levels of neutrophil granular proteins in TBL individuals upon anti-tuberculosis treatment (ATT) completion. In addition, we studied the correlation and discriminatory ability of NGPs using receiver operating characteristic (ROC) analysis.

Results
Our data suggests that systemic levels of NGPs (MPO, PRTN3, elastase) were significantly reduced in TBL individuals compared to LTB and HC individuals. Similarly, after ATT, the plasma levels of MPO and elastase but not PRTN3 were significantly elevated compared to pre-treatment levels. NGPs (except PRTN3) were positively correlated with absolute neutrophil count of TBL, LTB and HC individuals. Further, NGPs were able to significantly discriminate TBL from LTB and HC individuals.

Conclusion
Hence, we conclude reduced neutrophil granular protein levels might be associated with disease pathogenesis in TBL.
At a Moment’s Notice: Indonesian Maids Write on Their Lives Abroad, Jafar Suryomenggolo (ed. and trans.) (2019)
Authors: Liu Yiwen 
Published: June 2021

Review of: At a Moment’s Notice: Indonesian Maids Write on Their Lives Abroad, Jafar Suryomenggolo (ed. and trans.) (2019)
Copenhagen: NIAS Press, 219 pp.,
ISBN 978-8-77694-270-0, h/bk, £65.00;
ISBN 978-8-77694-271-7, p/bk, £19.99
Fourier transforms of convolution operators on orlicz spaces
Authors: Tabatabaie Seyyed Mohammad , Salec AliReza Bagheri 
Published: June 2021

AbstractIn this paper, we study convolution operators on an Orlicz spaceLΦ(G) commuting with left translations, where Φ is an N-function andGis a locally compact group. We also present some basic properties of the Fourier transform of a Φ-convolution operator in the context of locally compact abelian groups.
A nonparametric estimation of the conditional ageing intensity function in censored data: A local linear approach
Authors: Khardani Salah , Benkhaled Abdelkader 
Published: June 2021

AbstractIn this paper, we investigate the problem of the local linear estimation of the conditional ageing intensity function, when the variable of interest is subject to random right-censored. We establish under appropriate conditions the asymptotic normality of this estimator.
m6A‐mediated alternative splicing coupled with nonsense‐mediated mRNA decay regulates SAM synthetase homeostasis
Authors: Watabe Eichi , Togo‐Ohno Marina , Ishigami Yuma , Wani Shotaro , Hirota Keiko , Kimura‐Asami Mariko , Hasan Sharmin , Takei Satomi , Fukamizu Akiyoshi , Suzuki Yutaka , Suzuki Tsutomu , Kuroyanagi Hidehito 
Published: June 2021

AbstractAlternative splicing of pre‐mRNAs can regulate gene expression levels by coupling with nonsense‐mediated mRNA decay (NMD). In order to elucidate a repertoire of mRNAs regulated by alternative splicing coupled with NMD (AS‐NMD) in an organism, we performed long‐read RNA sequencing of poly(A)+ RNAs from an NMD‐deficient mutant strain of Caenorhabditis elegans, and obtained full‐length sequences for mRNA isoforms from 259 high‐confidence AS‐NMD genes. Among them are the S‐adenosyl‐L‐methionine (SAM) synthetase (sams) genes sams‐3 and sams‐4. SAM synthetase activity autoregulates sams gene expression through AS‐NMD in a negative feedback loop. We furthermore find that METT‐10, the orthologue of human U6 snRNA methyltransferase METTL16, is required for the splicing regulation in␣vivo, and specifically methylates the invariant AG dinucleotide at the distal 3′ splice site (3′SS) in␣vitro. Direct RNA sequencing coupled with machine learning confirms m6A modification of endogenous sams mRNAs. Overall, these results indicate that homeostasis of SAM synthetase in C. elegans is maintained by alternative splicing regulation through m6A modification at the 3′SS of the sams genes.
Dampak adanya pandemi bagi Lembaga Bimbingan Belajar (LBB)
Authors: Madhani L. R. , Sari K. A. , Rahmawati D. K. , Rozakiyah Desy Santi 
Published: June 2021

Covid-19 spreads so fast and has various impacts in society, one of which is in the world of formal education. The existence of a pandemic has resulted in learning to be carried out over a long distance network. This also has an impact on non-formal education such as the Tutoring Institution. LBB is an example of a non-formal education institution that guides students in academic lessons by adjusting their needs. The author tries to find the impact of a pandemic on LBB, what is felt by LBB and parents and students. This study aims to see the impact of the Pandemic Tutoring Institution, both formal and informal. This type of research is qualitative research using cognitive learning theory. Technique informants using purposive sampling technique. Sources of data used are interviews, observations, and literature studies. The results of the study explained that it would be healthy if LBB was kept open by implementing the Covid-19 health protocol, dividing students into several groups, and still maximizing courageous learning. The result of the research is that LBB must remain open because face-to-face learning is still needed by students who still need direct guidance such as kindergarten, elementary, and junior high school students/equivalent.
Covid-19 menyebar begitu cepat dan menimbulkan berbagai dampak di masyarakat, salah satunya pada dunia pendidikan formal. Adanya pandemi mengakibatkan pembelajaran harus dilakukan melalui jaringan jarak jauh. Hal ini juga berdampak pada pendidikan non formal seperti Lembaga Bimbingan Belajar. LBB merupakan salah satu contoh lembaga pendidikan non formal yang membimbing peserta didik terkait pelajaran akademis dengan menyesuaikan kebutuhan. Penulis berusaha mencari dampak adanya pandemi bagi LBB, apa saja yang dirasakan oleh pihak LBB maupun orang tua dan peserta didik. Penelitian ini bertujuan untuk mengetahui dampak adanya pandemi bagi Lembaga Bimbingan Belajar baik formal maupun informal. Jenis penelitian yang digunakan yaitu penelitian kualitatif dengan menggunakan teori belajar kognitif. Teknik pengumpulan informan dengan menggunakan teknik purposive sampling. Sumber data yang digunakan yaitu wawancara, observasi, dan studi literatur. Hasil penelitian menjelaskan bahwa alangkah baiknya jika LBB tetap dibuka dengan menerapkan protokol kesehatan Covid-19, membagi peserta didik dalam beberapa kelompok, dan tetap memaksimalkan pembelajaran daring. Dengan begitu kesimpulan dari hasil penelitian adalah LBB harus tetap dibuka karena pembelajaran tatap muka masih dibutuhkan oleh peserta didik yang masih membutuhkan bimbingan secara langsung seperti siswa TK, SD maupun SMP/sederajat.
Late Language Emergence
Authors: Nouraey Peyman , Ayatollahi Mohammad A , Moghadas Marzieh 
Published: June 2021

Infants usually say their first word at the age of 12 months; subsequently, within the next 6–12 months, they develop a vocabulary of approximately 50 words, along with the ability to make two-word combinations. However, late talkers (LTs) demonstrate delayed speech in the absence of hearing impairments, cognitive developmental issues or relevant birth history. The prevalence of late language emergence (LLE) in toddlers is reported to be 10–15%. Studies of LTs are both theoretically and clinically significant. Early diagnosis and clinical intervention may result in relatively stable speech capabilities by the early school years. The present article aimed to review both theoretical and empirical studies regarding LLE within the process of first language acquisition, as well as methods for the early diagnosis of delayed speech in children and the authors’ own clinical and theoretical recommendations.
Keywords: Infants; Speech; Language Development; Speech-Language Pathology; Language Development Disorders; Rehabilitation of Speech and Language Disorders.
COVID-19 and the Clinical Phase of the Medical Doctorate Curriculum in Oman
Authors: Burney Ikram A , Abdwani Reem , Al-Hashmi Khamis , Al-Wardy Nadia , Al-Saadoon Muna 
Published: June 2021

COVID-19 has gripped the world with lightning speed. Since the onset of the pandemic, activity throughout the world came to a grinding halt. However, business had to continue and people have to learn to live with the virus while the pandemic continues to rage. Medical education is no exception and may even deserve special mention, as it prepares frontline workers against the endemics of tomorrow. We discuss here the journey of medical education at the College of Medicine and Health Sciences at Sultan Qaboos University, Muscat, Oman, as the pandemic struck the world and Oman. This work suggests a roadmap for changes, discusses challenges and proposes measures to mitigate the effects of COVID-19 on medical schools.
Keywords: COVID-19; Medical Education; Curriculum; Computer Simulation; Artificial Intelligence; Oman.