bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between childhood maltreatment, poor sleep, and prenatal distress in pregnant adolescents
Authors: Foss Sophie , Gustafsson Hanna C. , Berry Obianuju O. , Hipwell Alison E. , Werner Elizabeth A. , Peterson Bradley S. , Monk Catherine 
Published: February 2021

AbstractChildhood maltreatment (CM) is a known risk factor for adolescent pregnancy. Sleep disturbances and psychological distress, both common negative sequelae of CM, often co-occur during pregnancy, although directionality remains unclear. Furthermore, little is known about how CM affects sleep–distress associations during pregnancy. In pregnant adolescents, we examined: (a) whether there are significant predictive associations from CM to sleep quality and distress and (b) bidirectional influences of distress and sleep quality. Healthy pregnant adolescents (n = 204) were recruited before or during the 2nd trimester. CM was assessed at enrollment; sleep quality and distress were assessed in the 2nd and 3rd trimesters. Hypotheses were tested using path analysis. Findings revealed that CM was associated with worse 2nd trimester sleep quality and distress (β = .19, p < .05 for sleep; β = .30, p < .001 for distress). Higher levels of 2nd trimester distress were associated with lower 3rd trimester sleep quality (β = .19, p < .05). Findings provide novel information about (a) associations from CM to prenatal mood and sleep in pregnant adolescents, and (b) sleep–distress directionality over the course of pregnancy. These results have implications for better understanding the ways in which CM potentially exerts influences later in life, and for targeting interventions to address physical and mental health during pregnancy.
Preoperative heart failure is not associated with impaired coagulation in paediatric cardiac surgery
Authors: Söderlund Fredrik , Wåhlander Håkan , Hansson Emma C. , Romlin Birgitta S. 
Published: February 2021

AbstractObjective:The objectives of the present study were to determine whether there was any association between the grade of heart failure, as expressed by preoperative levels of brain natriuretic peptide and Ross score, and the preoperative coagulation status in patients with non-restrictive ventricular shunts and determine whether there were any postoperative disturbances of the coagulation system in these patients, as measured by thromboelastometry and standard laboratory analyses of coagulation.Design:Perioperative coagulation was analysed with laboratory-based coagulation tests and thromboelastometry before, 8 hours after, and 18 hours after cardiac surgery. In addition, brain natriuretic peptide was analysed before and 18 hours after surgery.Patients:40 children less than 12 months old with non-restrictive congenital ventricular or atrio-ventricular shunts scheduled for elective repair of their heart defects.Results:All coagulation parameters measured were within normal ranges preoperatively. There was a significant correlation between brain natriuretic peptide and plasma fibrinogen concentration preoperatively. There was no statistically significant correlation between brain natriuretic peptide and INTEM-MCF, FIBTEM-MCF, plasma fibrinogen, activated partial thromboplastin time, prothrombin time, or platelet count at any other time point, either preoperatively or postoperatively. Postoperatively, fibrinogen plasma concentration and FIBTEM-MCF decreased significantly at 8 hours, followed by a large increase at 18 hours to higher levels than preoperatively.Conclusions:There was no evidence of children with non-restrictive shunts having coagulation abnormalities before cardiac surgery. Brain natriuretic peptide levels or Ross score did not correlate with coagulation parameters in any clinically significant way.
Transcarceral lawscapes enacted in moments of Aboriginalisation: a case-study of an Indigenous woman released on urban parole
Authors: Shaw Joshua David Michael 
Published: February 2021

AbstractThe field of carceral geography was lately developed by critical human geographers grappling with the spatiotemporal modes of social control and coercion particular to institutions of incarceration (Moranet al., 2018; Moran and Schliehe, 2017). This has included – in keeping with Michel Foucault's (1991) genealogy of the carceral as an art of disciplinary power – studying the disparate ways in which carceral techniques proliferate from and beyond the built site of the prison, becoming incorporated into other spatial formations. Carceral geographers have characterised this extension as transcarceral (Moran, 2014) or heterotopic (Gillet al., 2018; Moran and Keinänen, 2012). However, despite frequent references to law and legal institutions, carceral geographers generally do not theorise about law. Through a case-study involving an Indigenous woman paroled in Toronto, the author theorises about how carceral spaces are expressed through legal forms and techniques, affecting how paroled individuals, particularly thoseAboriginalised, are emplaced within urban space.
Regional Policies Targeting Residential Solid Fuel and Agricultural Emissions Can Improve Air Quality and Public Health in the Greater Bay Area and Across China
Authors: Conibear Luke , Reddington Carly L. , Silver Ben J. , Knote Christoph , Arnold Stephen R. , Spracklen Dominick V. 
Published: February 2021

AbstractAir pollution exposure is a leading public health problem in China. The majority of the total air pollution disease burden is from fine particulate matter (PM2.5) exposure, with smaller contributions from ozone (O3) exposure. Recent emission reductions have reduced PM2.5 exposure. However, levels of exposure and the associated risk remain high, some pollutant emissions have increased, and some sectors lack effective emission control measures. We quantified the potential impacts of relevant policy scenarios on ambient air quality and public health across China. We show that PM2.5 exposure inside the Greater Bay Area (GBA) is strongly controlled by emissions outside the GBA. We find that reductions in residential solid fuel use and agricultural fertilizer emissions result in the greatest reductions in PM2.5 exposure and the largest health benefits. A 50% transition from residential solid fuel use to liquefied petroleum gas outside the GBA reduced PM2.5 exposure by 15% in China and 3% within the GBA, and avoided 191,400 premature deaths each year across China. Reducing agricultural fertilizer emissions of ammonia by 30% outside the GBA reduced PM2.5 exposure by 4% in China and 3% in the GBA, avoiding 56,500 annual premature deaths across China. Our simulations suggest that reducing residential solid fuel or industrial emissions will reduce both PM2.5 and O3 exposure, whereas other policies may increase O3 exposure. Improving particulate air quality inside the GBA will require consideration of residential solid fuel and agricultural sectors, which currently lack targeted policies, and regional cooperation both inside and outside the GBA.
Effect of the Electric Field on the Agyrotropic Electron Distributions
Authors: Gao C.‐H. , Tang B.‐B. , Li W. Y. , Wang C. , Khotyaintsev Yu V. , Graham D. B. , Gershman D. J. , Rager A. C. , Giles B. L. , Lindqvist P. ‐A , Ergun R. E. , Russell C. T. , Burch J. L. 
Published: February 2021

AbstractWe investigate agyrotropic electron distributions from two magnetopause events observed by magnetospheric multiscale (MMS) spacecraft. Agyrotropic electron distributions can be generated by the finite electron gyration at an electron‐scale boundary, and the electric field normal to this boundary usually contributes to the electron acceleration to make the agyrotropic distributions more apparent. The effect of the electric field becomes important only when it is sufficiently strong and local, meaning its electrostatic potential is comparable to or larger than the electron temperature, and its width is smaller than the electron thermal gyroradius, so that this electric field can directly accelerate part of the electrons out of the original core to form agyrotropic electron distributions. Also, we reproduce the measured electron “finger” structures from test particle simulations, which can be effectively suppressed by increasing the sampling rate of the electron measurement.
Evaluating the Mobile Flux Plane (MFP) Method to Estimate Methane Emissions Using Large Eddy Simulations (LES)
Authors: Kumar Rajesh , Mitchell Douglas A. , Steinhoff Daniel F. , Saide Pablo , Kosovic Branko , Downey Nicole , Blewitt Doug , Monache Luca Delle 
Published: February 2021

AbstractThis study evaluates the efficacy of the mobile flux plane (MFP) method to derive methane emissions from oil and gas production fields using a first‐of‐its‐kind high‐resolution methane concentration data set. Transport and dispersion of methane emissions from seven hypothetical well pads generated with an oil field emission simulator is simulated every second at 10 m resolution using the Weather Research and Forecasting (WRF) model in large eddy simulation mode. The time varying WRF‐generated methane concentration data set is sampled by a simulated MFP system downwind of the seven well pads at five sampling distances of 50, 75, 100, 125, and 150 m. Several key findings highlight the significant variability in MFP emission rate estimates induced by atmospheric turbulence and variable source emission rates. Natural atmospheric turbulence alone was found to generate significant variability (33%–75%) in the MFP emission estimates with constant emission rates at the source location. It was also found that turbulent wind speed fluctuations over the duration of a transect can also affect MFP estimates up to about ±50% through convergence (divergence) that increases (decreases) methane concentrations, and by its effect on the assumption of steady winds over the duration of the transect. It was further found that the MFP method typically estimated about 19%–33% and 51%–75% of known site emission rates using the trapezoidal and Gaussian fit integration methods, respectively. Thus, methane concentrations would need to be measured to a much higher elevation to generate robust and accurate methane emission rate estimates.
Disentangling the Regional Climate Impacts of Competing Vegetation Responses to Elevated Atmospheric CO2
Authors: McDermid Sonali Shukla , Cook Benjamin I. , De Kauwe Martin G. , Mankin Justin , Smerdon Jason E. , Williams A. Park , Seager Richard , Puma Michael J. , Aleinov Igor , Kelley Maxwell , Nazarenko Larissa 
Published: February 2021

AbstractBiophysical vegetation responses to elevated atmospheric carbon dioxide (CO2) affect regional hydroclimate through two competing mechanisms. Higher CO2 increases leaf area (LAI), thereby increasing transpiration and water losses. Simultaneously, elevated CO2 reduces stomatal conductance and transpiration, thereby increasing rootzone soil moisture. Which mechanism dominates in the future is highly uncertain, partly because these two processes are difficult to explicitly separate within dynamic vegetation models. We address this challenge by using the GISS ModelE global climate model to conduct a novel set of idealized 2×CO2 sensitivity experiments to: evaluate the total vegetation biophysical contribution to regional climate change under high CO2; and quantify the separate contributions of enhanced LAI and reduced stomatal conductance to regional hydroclimate responses. We find that increased LAI exacerbates soil moisture deficits across the sub‐tropics and more water‐limited regions, but also attenuates warming by ∼0.5–1°C in the US Southwest, Central Asia, Southeast Asia, and northern South America. Reduced stomatal conductance effects contribute ∼1°C of summertime warming. For some regions, enhanced LAI and reduced stomatal conductance produce nonlinear and either competing or mutually amplifying hydroclimate responses. In northeastern Australia, these effects combine to exacerbate radiation‐forced warming and contribute to year‐round water limitation. Conversely, at higher latitudes these combined effects result in less warming than would otherwise be predicted due to nonlinear responses. These results highlight substantial regional variation in CO2‐driven vegetation responses and the importance of improving model representations of these processes to better quantify regional hydroclimate impacts.
Seasonal and Spatial Variability of Carbon Monoxide (CO) in the Martian Atmosphere From PFS/MEX Observations
Authors: Bouche Jimmy , Coheur Pierre‐François , Giuranna Marco , Wolkenberg Paulina , Nardi Luca , Amoroso Marilena , Vandaele Ann Carine , Daerden Frank , Neary Lori , Bauduin Sophie 
Published: February 2021

AbstractA subset of more than 100,000 nadir measurements covering more than 7 Martian years (MY 26–MY 33) recorded in the thermal part of the Short Wavelength Channel (SWC) from the Planetary Fourier Spectrometer (PFS) on board Mars Express is exploited to investigate the global distribution and the seasonal cycle of carbon monoxide (CO) on Mars. The retrieval of CO vertical profiles is successfully achieved using a methodology based on the optimal estimation but the low information content is such that we mainly discuss the variability in CO in terms of integrated columns (from the surface to 24 km) or the associated column‐averaged mixing ratio. We find a strong seasonality in CO, especially at mid and high‐latitudes, which confirms earlier work and the current knowledge of the CO2 condensation/sublimation cycles, as implemented for instance in the Global Environmental Multiscale (GEM) general circulation model for Mars, that we use as a basis for comparison. We report a general consistency between model and observation, with a tendency of the latter to provide lower CO volume mixing ratios (VMRs), except at low latitudes. The spatial distribution of the CO column‐averaged VMR is obtained on a seasonal basis and investigated in terms of large‐scale patterns but also local peculiarities. Finally, we show that the retrieved profiles systematically present strong CO vertical gradients close to the surface in mid‐ and equatorial latitudes, likely related to the vertical sensitivity of PFS rather than real near‐surface CO enrichment.
Climate, Fuel, and Land Use Shaped the Spatial Pattern of Wildfire in California’s Sierra Nevada
Authors: Chen Bin , Jin Yufang , Scaduto Erica , Moritz Max A. , Goulden Michael L. , Randerson James T. 
Published: February 2021

AbstractCalifornia’s Sierra Nevada has experienced a large increase in wildfire activities over recent decades. This intensifying fire regime has coincided with a warming climate and increasing human activity, but the relative importance of the biophysical and anthropogenic drivers of wildfire remains unclear across this diverse landscape, especially at a finer spatial scale. We used multisource geospatial data sets of fire occurrence, and human, climatic, and biophysical variables to examine the spatial pattern and controls on Sierra Nevada wildfires averaged from 1984 to 2017. The maximum entropy model driven by both biophysical and anthropogenic variables predicted the spatial distribution of fire probability well, with an area under the curve (AUC) score of 0.81. Model diagnostics revealed that aspects of the climate, including vapor pressure deficit (VPD), temperature, and burning index (difficulty of control), dominated the spatial patterns of fire probability across the whole Sierra Nevada region. The VPD was the leading control, with a relative contribution of 32.1%. Population density and fuel amount were also significant drivers, each accounting for 15.8%–12.4% of relative contribution. VPD and burning index were the most important factors for fire probability in higher elevation forest, while population density was comparatively more important in the lower elevation forest regions of the Sierra Nevada. Our findings improved our understanding of the relative importance of various factors in shaping the spatial patterns of historical fire probability in the Sierra Nevada and across various subecoregions, providing insights for targeting spatially varying forest management strategies to limit potential future increases in wildfires.
Punctuated Orogeny During the Assembly of Asia: Tectonostratigraphic Evolution of the North China Craton and the Qilian Shan From the Paleoproterozoic to Early Paleozoic
Authors: Wu Chen , Zuza Andrew V. , Yin An , Chen Xuanhua , Haproff Peter J. , Li Jie , Li Bing , Ding Lin 
Published: February 2021

AbstractThe Proterozoic‐Phanerozoic evolution of the Tarim and North China cratons is integral to the construction of the Eurasian continent. Throughout the Paleozoic, these continents were bound by the Paleo‐Asian and Tethyan Oceans to the north and south, respectively, and, thus, their paleogeography is critical to reconstructions of the oceanic domains. Specifically, it remains uncertain whether the Tarim and North China cratons were contiguous during the Paleozoic. Geologic observations from the Qilian Shan and Longshou Shan of western China provide valuable information regarding the paleotectonic relationships of these continents. Here we present detailed field, geochronological, and geochemical observations from key locations in the Qilian Shan and Longshou Shan to decipher complex relationships between the Kunlun‐Qaidam, North China, and Tarim continents. Paleoproterozoic deformation might have been associated with the northern North China orogen, whereas a Neoproterozoic collisional orogen occurred between the Kunlun‐Qaidam‐South Tarim and the North China‐North Tarim. Subsequent late Neoproterozoic rifting led to the opening of the Qilian ocean as an embayed marginal sea, and the Paleo‐Asian Ocean developed along the northern margin of the North China craton. South‐dipping subduction, arc magmatism, slab rollback, and convergence between Kunlun‐Qaidam and North China continued throughout the Early Silurian, which were recorded in the Qilian Shan and Longshou Shan regions. Our updated geotectonic framework requires reevaluation of previously published paleogeographic models, including ones that suggest the North China craton was affixed to Gondwana in the early Paleozoic. It is further considered a possible connection between the North China and southern Africa at ca. 2.05 Ga.
Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro
Authors: Daniels Lorna J. , Annandale Marco , Koutsifeli Parisa , Li Xun , Bussey Carol T. , van Hout Isabelle , Bunton Richard W. , Davis Philip J. , Coffey Sean , Katare Rajesh , Lamberts Regis R. , Delbridge Lea M. D. , Mellor Kimberley M. 
Published: February 2021

AbstractDiabetes is associated with cardiac metabolic disturbances and increased heart failure risk. Plasma fructose levels are elevated in diabetic patients. A direct role for fructose involvement in diabetic heart pathology has not been investigated. The goals of this study were to clinically evaluate links between myocardial fructose and sorbitol (a polyol pathway fructose precursor) levels with evidence of cardiac dysfunction, and to experimentally assess the cardiomyocyte mechanisms involved in mediating the metabolic effects of elevated fructose. Fructose and sorbitol levels were increased in right atrial appendage tissues of type 2 diabetic patients (2.8- and 1.5-fold increase respectively). Elevated cardiac fructose levels were confirmed in type 2 diabetic rats. Diastolic dysfunction (increased E/e’, echocardiography) was significantly correlated with cardiac sorbitol levels. Elevated myocardial mRNA expression of the fructose-specific transporter, Glut5 (43% increase), and the key fructose-metabolizing enzyme, Fructokinase-A (50% increase) was observed in type 2 diabetic rats (Zucker diabetic fatty rat). In neonatal rat ventricular myocytes, fructose increased glycolytic capacity and cytosolic lipid inclusions (28% increase in lipid droplets/cell). This study provides the first evidence that elevated myocardial fructose and sorbitol are associated with diastolic dysfunction in diabetic patients. Experimental evidence suggests that fructose promotes the formation of cardiomyocyte cytosolic lipid inclusions, and may contribute to lipotoxicity in the diabetic heart.
Characterization of ferroptosis in kidney tubular cell death under diabetic conditions
Authors: Kim Seonghun , Kang Shin-Wook , Joo Jeongho , Han Seung Hyeok , Shin Huiyoon , Nam Bo Young , Park Jimin , Yoo Tae-Hyun , Kim Gyuri , Lee Pureunchowon , Park Jung Tak 
Published: February 2021

AbstractKidney tubular cell death induced by transforming growth factor-β1 (TGF-β1) is known to contribute to diabetic nephropathy, a major complication of diabetes. Caspase-3-dependent apoptosis and caspase-1-dependent pyroptosis are also involved in tubular cell death under diabetic conditions. Recently, ferroptosis, an atypical form of iron-dependent cell death, was reported to cause kidney disease, including acute kidney injury. Ferroptosis is primed by lipid peroxide accumulation through the cystine/glutamate antiporter system Xc− (xCT) and glutathione peroxidase 4 (GPX4)-dependent mechanisms. The aim of this study was to evaluate the role of ferroptosis in diabetes-induced tubular injury. TGF-β1-stimulated proximal tubular epithelial cells and diabetic mice models were used for in vitro and in vivo experiments, respectively. xCT and GPX4 expression, cell viability, glutathione concentration, and lipid peroxidation were quantified to indicate ferroptosis. The effect of ferroptosis inhibition was also assessed. In kidney biopsy samples from diabetic patients, xCT and GPX4 mRNA expression was decreased compared to nondiabetic samples. In TGF-β1-stimulated tubular cells, intracellular glutathione concentration was reduced and lipid peroxidation was enhanced, both of which are related to ferroptosis-related cell death. Ferrostatin-1 (Fer-1), a ferroptosis inhibitor, alleviated TGF-β1-induced ferroptosis. In diabetic mice, kidney mRNA and protein expressions of xCT and GPX4 were reduced compared to control. Kidney glutathione concentration was decreased, while lipid peroxidation was increased in these mice, and these changes were alleviated by Fer-1 treatment. Ferroptosis is involved in kidney tubular cell death under diabetic conditions. Ferroptosis inhibition could be a therapeutic option for diabetic nephropathy.
HMGB1 orchestrates STING-mediated senescence via TRIM30α modulation in cancer cells
Authors: Lee Je-Jung , Park In Ho , Kwak Man Sup , Rhee Woo Joong , Kim Songhee H. , Shin Jeon-Soo 
Published: February 2021

AbstractAlthough cellular senescence has emerged as a novel therapeutic concept in cancer, its underlying mechanisms remain unclear. High mobility group box 1 (HMGB1) and stimulator of interferon genes (STING) are involved in senescence. However, their interactions in senescence have not been reported. Therefore, in this study, we investigated the relationships between HMGB1 and STING in senescence in cancer and other cells. In mouse melanoma cells and several other cell lines, doxorubicin treatment induced senescence in an HMGB1-dependent manner. These responses were mediated by STING, and this function of STING was negatively regulated by the E3 ligase tripartite motif protein 30α (TRIM30α). We also found that HMGB1 bound to the TRIM30α promoter and then suppressed its expression by inhibiting its transcription, which enhanced STING-induced senescence. This mechanism was further mediated by signal transducer and activator of transcription 6 (STAT6) and p21. Overall, our findings demonstrated that HMGB1 orchestrated STING-STAT6-p21-mediated senescence by regulating TRIM30α as an alternative anticancer mechanism.