bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary L-Type Fatty Acid-Binding Protein is a Predictor of Cisplatin-Induced Acute Kidney Injury.
Authors: Yanishi Masaaki , Kinoshita Hidefumi 
Published: October 2021

Abstract
Background
Although cisplatin-based chemotherapy is a standard treatment for urothelial carcinoma, it often causes acute kidney injury (AKI). AKI and dysfunction are observed in 25–35% of cisplatin-based chemotherapy patients, who may require treatment down-titration or withdrawal. In this study, we evaluated whether urinary L-FABP is a marker for early diagnosis of cisplatin-caused AKI.
Methods
We included 42 adult patients who underwent cisplatin-based chemotherapy for bladder cancer or upper tract urothelial carcinoma from January 2018 to March 2019. Urinary L-FABP and serum creatinine were measured at 2 and 6 hours, and 1, 2, 3, 7 and 28 days after taking cisplatin.
Results
In the first week after receiving cisplatin, 10 patients (23.8%) were diagnosed with AKI (AKI+ group). Pre-treatment (baseline) measurements did not significantly differ between the AKI+ and AKI− groups. However, urinary L-FABP concentrations rapidly increased in the AKI+ group and were significantly greater than in the AKI− group at Hour 2, Hour 6, Day 1 and Day 2. Serum creatinine also significantly differed between the AKI+ group and the AKI− group on Days 3 and 7.
Conclusions
Acute renal function deterioration was predicted by increased urinary L-FABP excretion within six hours after receiving CIS-CT and, in those with AKI, the increase in urinary L-FABP excretion preceded the rise in sCr by over 2 days. In contrast, no appreciable changes in urinary L-FABP levels were observed in patients with stable renal function throughout the whole observation period. So early increase in urinary L-FABP may identify patients at risk of cisplatin-induced AKI, who might benefit from treatment to prevent nephrotoxicity.
Trial registration:
This study was retrospectively registered.
Simple Topographic Parameter Reveals the Along-Trench Distribution of Frictional Properties on a Shallow Plate Boundary Fault
Authors: Koge Hiroaki , Ashi Juichiro , Park Jin-Oh , Miyakawa Ayumu , Yabe Suguru 
Published: October 2021

Abstract
The critical taper model of a sedimentary wedge best describes the first-order mechanics of a subduction zone wedge. The tapered wedge geometry, which is conventionally defined by two parameters, the slope angle and the basal dip angle, is responsible for the strength of a megathrust. By applying this theoretical model to subduction zones, fault frictional properties and earthquake occurrences can be compared among subduction zones, and within a single subduction zone, the spatial distribution or temporal change of fault strength can be investigated. The slope angle can be accurately estimated from bathymetry data, but the basal dip angle must be inferred from the subsurface structure, and it requires highly accurate depth-converted seismic reflection profiles. Thus, application of the critical taper model is often limited by a lack of a sufficient number of highly accurate profiles, and the spatial distribution of frictional coefficients must be inferred from relatively few data, generally less than a dozen points. To improve this situation, we revisited the theoretical formula of the critical taper model. We found that the effect of the décollement dip angle β on the critical taper model of a sedimentary wedge is negligible when the pore fluid pressure ratio is high or internal friction is small, conditions which are met in many subduction zones. Therefore, this finding allows frictional variation to be approximated by using only the slope angle variation obtained from the bathymetry. We applied this approximation to the Japan Trench as an example of this approximation, and were able to estimate the friction coefficient distribution on the shallow plate boundary fault from 71 data points. We found that the area where the friction coefficient was smaller than the mean corresponded to the segment where a large coseismic shallow rupture occurred during the 2011 Tohoku-oki earthquake (Mw 9.0). This result shows that by approximating tapered wedge geometry using a simple topographic parameter that can be obtained from existing global bathymetry, we can quickly estimate the distribution of frictional properties on a plate boundary fault along a trench and related seismic activity.
Nitrogen Uptake by Plants May Alleviate N Deposition-induced Increase in Soil N2O Emissions in Subtropical Chinese Fir Plantations
Authors: Zheng Xiang , Liu Qi , Cao Minmin , Ji Xiaofang , Lu Jianbing , He Liu , Liu Lingjuan , Liu Shenglong , Jiang Jiang 
Published: October 2021

Abstract
BackgroundContinuous increasing nitrogen (N) deposition interferes with soil nitrogen cycle of forests, which highly impacts soil N2O emissions and accelerates global warming. Chinese fir (Cunninghamia lanceolata (Lamb.) Hook) is one of the most widely planted species in southern China which locates in the high N deposition area. However, the impact of N deposition on soil N2O emissions in subtropical Chinese fir plantations and the potential risk of increasing N deposition still remain elusive. Here, we conducted an in situ study in a subtropical Chinese fir plantation at Fengyang Mountain Nature Reserve, China, from 2019-2020 with four different levels of N enrichment: control (CK: ambient N deposition), low-N (LN: 50 kg N ha−1 yr−1), medium-N (MN: 100 kg N ha−1 yr−1), and high-N (HN: 200 kg N ha−1 yr−1). ResultsWe found that soil N2O emission rates increased with N enrichment from an average of 5.89 ± 3.66 to 20.11 ± 3.44 μg N m−2 h−1. The N enrichment in general showed no significant effect on the abundance of nitrate-reducing bacteria, but it tended to raise the abundance of ammonia oxidizing archaea and bacteria, and to decrease the abundance of N2O-reducing bacteria, which likely provided the microbial basis for accelerating soil N2O emissions along with increasing N deposition. However, the relationship of soil N2O emissions with N input did not match an exponential increase, but it matched a logarithmic increase, illustrating that the risk of increasing N deposition on soil N2O emissions was attenuated. It is found that N enrichment significantly decreased soil moisture and tended to increase the fir leaf N concentrations and soil CO2 emission rates. Besides, soil microbial biomass was significantly suppressed by N enrichment during the mid-growing season, while not in end of growing season. These may suggest that N enrichment stimulated plant growth with more N and water uptake, which competed with microorganisms for N and therefore alleviated further increasing N2O emissions under N enrichment. ConclusionThis study deepen our understanding of the impacts of increased N deposition on the greenhouse gas (GHG) balance in the Chinese fir plantations, and highlight that plants need to be incorporated as an important explanatory variable when predicting GHG fluxes in the background of global increasing N deposition.
Simultaneous Monitoring of the Middle Cerebral and Basilar Arteries to Detect Right-to-Left Shunts Using Transcranial Doppler by Agitated Saline Administration
Authors: Kim Min , Park So Young , Hong Ji Man 
Published: October 2021

Abstract
Transcranial Doppler (TCD) is an easy, non-invasive, and real-time monitoring device for detecting right-to-left shunts (RLS). Nonetheless, it has limited benefits in patients with poor temporal windows. Therefore, we aimed to investigate whether the basilar artery (BA) window was as effective as the middle cerebral artery (MCA) in detecting RLS during TCD monitoring. Overall, we enrolled 344 patients with stroke, transient ischemic attack, headache, or dizziness. MCA and BA were monitored using a modified headset. To investigate the feasibility of the suboccipital window in detecting RLS, we instituted an evaluation tool with three tiers to evaluate microembolic signals (MESs) during TCD monitoring. Tier 1: TCD monitoring of the MCA (bilaterally) in the resting state, tier 2: TCD monitoring of the MCA (bilaterally) while performing the Valsalva maneuver, and tier 3: TCD monitoring of the index MCA and BA while performing the Valsalva maneuver. In tiers 2 and 3, a high agreement rate of 0.8076 and 0.8068 (p<0.001), respectively, on the weighted kappa index, and a high intra-class correlation coefficient of 0.9822 and 0.9860 (p<0.001), respectively, were observed on detecting MESs. Our data suggests that the BA window is as effective as the MCA window for detecting RLS on TCD.
Respiratory Viruses Dynamics and Interactions: Ten Years of Surveillance in Central Europe
Authors: Horemheb-Rubio Gibran , Eggeling Ralf , Schmeisser Norbert , Pfeifer Nico , Lengauer Thomas , Gärtner Barbara C. , Prifert Christiane , Kochanek Matthias , Scheid Christoph , Adams Ortwin , Kaiser Rolf 
Published: October 2021

Abstract
Background: Lower respiratory tract infections are among the main causes of death. Although there are many respiratory viruses, diagnostic efforts are focused mainly on influenza. The Respiratory Viruses Network (RespVir) collects infection data, primarily from German university hospitals, for a high diversity of infections by respiratory pathogens. In this study, we computationally analysed a subset of the RespVir database, covering 217,150 samples tested for 17 different viral pathogens in the time span from 2010 to 2019. Methods: We calculated the prevalence of 17 respiratory viruses, analysed their seasonality patterns using information-theoretic measures and agglomerative clustering, and analysed their propensity for dual infection using a new metric dubbed average coinfection exclusion score (ACES). Results: After initial data pre-processing, we retained 206,814 samples, corresponding to 1,408,657 performed tests. We found that Influenza viruses were reported for less than half of all infections and that they exhibited the highest degree of seasonality Coinfections of viruses are frequent, the most prevalent coinfection was rhinovirus/bocavirus and most of the virus pairs had a positive ACES indicating a tendency to exclude each other regarding infection. Conclusions: The analysis of respiratory viruses dynamics in monoinfection and coinfection contributes to the prevention, diagnostic, treatment, and development of new therapeutics. Data obtained from multiplex testing is fundamental for this analysis and should be prioritized over single pathogen testing.
Challenges for innovation in health: the Brazilian experience of Public-Private Partnerships for Productive Development in the Economic Industrial Health Complex and Universal Health Coverage context
Authors: Rezende Kellen , Felipe Maria Sueli Soares , Gadelha Carlos Augusto Grabois 
Published: October 2021

Abstract
Objectives. To provide the conceptual, historical, and normative framework, the analysis of aims and criteria for the establishment of public-private partnerships (Partnerships for Productive Development) in the period of 2009-2020, in the context of the industrial economic complex that serves the Brazilian public health system. Methods. We presented the conceptual, historical, and normative framework of Partnerships for Productive Development using exploratory and documental bibliography to build an introductory contextual narrative review. We analyzed the objectives from its regulatory framework and the guiding normative criteria of these technology transfer projects. We assigned the Public Health Implications with critical analysis for the establishment of the public-private partnerships in the present context. Results. For a decade, technology transfer projects for the production of strategic inputs have been established in Brazil. The regulatory framework is established that includes the procedures, objectives, and criteria. The priority objectives originated in 2009, being the main motivators: expansion of access, productive and technological development in the country, and savings for the Ministry of Health. In 2020, 81 projects were in force, including 75 drugs, vaccines, and blood products and six health product projects. Among the drug partnerships, 33% of the projects are in an effective technology transfer phase. The guidelines and requirements were analyzed in terms of participants, object, intellectual property, schedules, documentation for registration with the National Health Surveillance Agency and certification of production lines, productive integration of the active pharmaceutical ingredient, production process, price, supply capacity, balance exchange, risk analysis, and necessary investments. Conclusions. The Partnerships for Productive Development present critical aspects for their conclusion considering the priority objectives. The difficulties to carry out the technology transfers in progress for the national production of strategic inputs are the maintenance of the economy for federal public purchases, the national industries production, the actions for monitoring and evaluation, and, finally, can be listed, the reconstruction of political and decision-making governance in the context of the Ministry of Health of Brazil.
Methodology of Analysing Geodetic Network as Basis for Developing Mobile Application for Its Ongoing Update
Authors: Przewięźlikowska Anna , Ślusarczyk Wioletta , Wójcik Klaudia 
Published: October 2021

Abstract
The final result of surveys largely depends on the accuracy and timeliness of the control network. This research paper presents the relationship between the condition of the points and the area where they are located. The main goal of this study is to present the methodology of a detailed analysis of the database of vertical control points in a selected area that is used to develop a mobile application intended for the update of the existing set of points of the vertical control network on an ongoing basis. In order to prepare the mobile application for the ongoing update of the control network, it is necessary to define detailed procedures for dealing with the database of points. These procedures concern the determination of the methodology of making an inventory of the existing database, and then the determination of the rules for updating the control network using the developed application.
Refinement of the Fusion Tag PagP For Efficient Inclusion Body-Targeted Expression of Recombinant Antimicrobial Peptides in Escherichia Coli
Authors: Li Xuefeng , Zhang Baorong , Hu Quan , Chen Changchao , Liu Lu , Luo Wenshi , Wang Shengbin 
Published: October 2021

Abstract
The methods developed for efficient insoluble protein production are less well explored. Our data demonstrated that PagP, an E. coli outer membrane protein with high β-sheet content, could function as an efficient fusion partner for inclusion body-targeted expression of antimicrobial peptide Magainin II, Metchnikowin and Andropin. The primary structure of a given polypeptide determines to a large extent its propensity to aggregate. The aggregation “hot spots” (HSs) in PagP was subsequently analyzed with the web-based software AGGRESCAN, leading to identification of the C-terminal region with high dense distribution of HSs. The absolute yields of recombinant antimicrobial peptide Metchnikowin and Andropin could be increased significantly when expressed in fusion with this version of PagP. Moreover, a Proline-rich region was found in the β-strands of PagP. Substitution for these prolines by residues with high β-sheet propensity and hydrophobicity significantly improved its ability to form aggregates, and greatly increased the yield of the recombinant passenger peptides. Fewer examples have been presented to separate the recombinant target proteins expressed in fusion inclusion bodies. Here, we reported an artificial linker peptide NHT with three motifs, by which separation and purification of the authentic recombinant antimicrobial peptides could be implemented.
The Progression of Peripheral Anterior Synechia after Combined Phacoemulsification with Goniosynechialysis Under an Ophthalmic Endoscope: A Three-Year Study
Authors: Liu Xinyi , Chan Yau Kei , Fu Lin , Song Yunhe , Li Junhua , Nie Li , Zhang Xiulan , Pan Weihua 
Published: October 2021

Abstract
Aim To investigate the long-term changes of peripheral anterior synechia (PAS) after phacoemulsification with goniosynechialysis under an ophthalmic endoscope (Phaco-OE-GSL) in primary angle-closure glaucoma (PACG) assisted with viscoelastics alone or viscoelastics combined with iris repositor (viscoelastics-repositor). Method A retrospective study was conducted. Thirty-nine eyes of 31 PACG patients were included. The follow-up period was 36 months. The main outcomes of the study included the changes of PAS, intraocular pressure (IOP), and the success rate.Results Phaco-OE-GSL was performed assisted with viscoelastics-alone on 20 eyes, and viscoelastics-repositor on 19 eyes. The total recurrence rates of PAS were 62.5% in viscoelastics-alone group and 87.5% in viscoelastics-repositor group. In particular, the recurrence rate of PAS at the same location at which were separated intraoperatively were 37.3% and 75.0% respectively (P=0.033). The recurrence of PAS was observed in 2 eyes in viscoelastics-alone group and 12 eyes in viscoelastics-repositor group within 1-month follow-up (P<0.001). In addition, comparing any two follow-ups 6 months after surgery, there are not significant differences in the extent of re-PAS in total eyes (P>0.05). The extent of postoperative PAS at final follow-up was positively correlated with the range of PAS preoperatively (P=0.036, r=0.356). The complete success rates were 85.0% and 89.5% of viscoelastics-alone group and viscoelastics-repositor group at 36-month follow-up respectively. Both the preoperative and postoperative distribution of PAS are mainly concentrated on the upper (84.6% and 95.8%) and nasal side (74.4% and 62.5%), followed by the inferior side, and the least on the temporal side. Conclusion In summary, although the recurrence rate of PAS was high in early postoperative period, the progression of PAS was rapidly resolved after 6 months postoperatively, and Phaco-OE-GSL is an eﬀective treatment for the long-term control of IOP of PACG patients especially with large range of PAS (> 180°). Both preoperative and postoperative PAS are mainly concentrated on the upper and nasal side. Besides, our results suggested that mechanical separation may be easier to promote the progression of postoperative PAS than viscoelastics-alone separation.
Visible-light Responsive Cu-MOF-NH 2 for Highly Efficient Aerobic Photocatalytic Oxidation of Benzyl Alcohol
Authors: Abdel-Azim Samira , Aman Delvin , steen eric van , Salam Howaida Abd El 
Published: October 2021

Abstract
The current study focuses on the photocatalytic oxidation of benzyl alcohol in acetonitrile under air bubbling conditions comparing titania-based materials, Cu-MOF, and Cu-MOF-NH2 as semiconductor photocatalysts. The catalysts were characterized by XRD, N2 adsorption-desorption, FT-IR, Raman spectroscopy, and TEM. The photocatalytic benzyl alcohol conversion reached ~ 100% after exposing the four prepared catalysts to a 125W mercury lamp for up to 240 min. Benzaldehyde is formed with a moderate selectivity (after a reaction time of 60 min. ca. 30% over the titania-based catalysts 37%, 45% over Cu-MOF, and Cu-MOF-NH2, respectively). The formation of electron-hole pairs at the surface of the semiconductor nanoparticles followed by oxidation reaction was the suggested mechanism. A first-order kinetic model was observed for the photocatalytic oxidation of the investigated alcohols, and the rate constants were calculated. According to preliminary research, decorating MOF linker by amine (MOF-NH2) could improve visible-light harvesting, charge separation, and electron transport of the resulting catalyst, resulting in increased photocatalytic activity. The current work offers some direction for the development of MOF-based photocatalysts for organic synthesis.
Verification of Monolithic Rotary Cutting Tool For Active Driven Rotation Machining
Authors: Czán Andrej , Joch Richard , Šajgalík Michal , Holubjak Jozef , Horák Andrej , Timko Pavol , Valíček Jan , Kušnerová Milena , Harnicarova Marta 
Published: October 2021

Abstract
Forced rotation turning appears to be an effective machining method due to higher tool life, time efficiency and acceptable quality. Several studies have been carried out to investigate the basic characteristics of forced rotation machining. So far, tools are used whose design included several components. However, such tools may generate vibrations, which are undesirable in the process. In engineering practice, most vibration problems are solved by reducing the cutting parameters (cutting speed and feed rate), which reduces machining productivity. For this reason, a new type of monolithic rotary tool has been designed that eliminates the design complexity and high assembly accuracy requirements of current rotary tools. The presented solution fundamentally validates the new monolithic tool for forced rotation technology and defines its application for different machining materials.
Heightened facial muscle reactivity in preadolescent girls with pathological anxiety
Authors: Cruz Joshua R. , Williams Lisa E. , Cochran Amy , McFarlin Daniel R. , Kalin Ned H. 
Published: October 2021

Abstract

Anticipatory anxiety and heightened responses to uncertainty are central features of anxiety disorders (ADs). We examined facial emotional responding in a sample of preadolescent girls with a range of anxiety symptoms: no/low anxiety (controls) to subthreshold anxiety (subthreshold-AD) to DSM-5 diagnoses of separation, social, and/or generalized ADs. Using a threat anticipation paradigm, we assessed how variations in image valence (negative vs. neutral) and image anticipation (uncertain vs. certain timing) impacted activity of the corrugator supercilii, a forehead muscle implicated in the ‘frown’ response that modulates to emotional stimuli (negative>neutral). Average corrugator magnitude and corrugator time-course were compared between groups. Findings demonstrate greater corrugator activity during anticipation and viewing of negative stimuli, with overall increased corrugator reactivity in subthreshold-AD and AD girls. Time-course analyses revealed anxiety-related sustained corrugator activity during uncertain anticipation of negative images. Results extend the physiological characterization of childhood pathological anxiety, highlighting the impact of subthreshold-AD symptoms.