bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERENCANAAN PEMBUKAAN PROGRAM STUDI KEDOKTERAN UPN VETERAN JAWA TIMUR DENGAN MODEL SIMULASI DINAMIS
Authors: Puspitasari Dessy Indra , Donoriyanto Dwi Sukma , Purnamawati Erlina , Moenandar Siswanto , Widodo Laurentius Urip 
Published: March 2021

Pendidikan adalah usaha yang dilakukan secara sadar dan terencana untuk mewujudkan suasana belajar dan proses pembelajaran sehingga peserta didik secara aktif dapat mengembangkan potensi dirinya yang diperlukan bagi dirinya masyarakat, bangsa dan negara. UPN ”Veteran” Jatim atau UPN V JT atau Universitas Pembangunan Nasional “Veteran” Jawa Timur, berlokasi di Surabaya merupakan salah satu perguruan tinggi negeri di Indonesia yang berdiri sejak 5 juli 1959. Pada Universitas Pembangunan Nasional “Veteran” Jawa Timur akan menambah program studi yaitu kedokteran. Metode penelitian yang digunakan adalah simulasi sistem dinamis, sebagai metode untuk membentuk suatu model simulasi computer, untuk membantu mempelajari kompleksitas dinamis, mengerti sumber resistensi kebijakan, dan mendesain kebijakan yang lebih efektif. Dari hasil simulasi kebijakan menggunakan software vensim yakni jumlah dokter cenderung meningkat. Jika tidak ada kebijakan penambahan program studi kedokteran, jumlah dokter pada tahun 2024 adalah 4351.96 ribu. Sedangkan jika terdapat kebijakan pembangunan program studi kedokteran, maka jumlah dokter pada tahun 2024 adalah 4419.86 ribu. Dan jumlah kebutuhan dokter cenderung menurun. Jika tidak ada kebijakan penambahan program studi kedokteran, jumlah kebutuhan dokter pada tahun 2024 adalah 410.917 ribu. Sedangkan jika terdapat kebijakan pembangunan program studi kedokteran, maka jumlah kebutuhan dokter pada tahun 2024 adalah 409.74 ribu.
Kata Kunci: Jumlah kebutuhan dokter,Software Vensim,Sistem dinamis, desain kebijakan.
MODEL JARINGAN RANTAI PASOK UNTUK POS PEMADAM KEBAKARAN DI KAWASAN SIER
Authors: Febryanto Indra Dwi , Prihono Prihono 
Published: March 2021

Perancangan jaringan rantai pasok bisa diaplikasikan dalam industri manufaktur maupun jasa, misalnya dalam menentukan lokasi pos pemadam kebakaran. Perancangan jaringan rantai pasok penting dilakukan khususnya mengenai pos pemadam kebakaran karena belum terdapat pelayanan yang optimal di hampir seluruh kawasan perindustrian di Indonesia. Metode yang digunakan dalam penelitian adalah set covering problem. Set covering problem memuat variabel keputusan tentang pos pemadam kebakaran mana yang nantinya akan digunakan untuk menjangkau seluruh area SIER. Pos pemadam kebakaran yang digunakan ada 4 yaitu Pos UPTD III, Pos Kali Rungkut, Pos Kepuh, dan Pos Sukolilo. Hasil dari penelitian ini adalah bahwa untuk jarak jangkauan 100-1000 meter ke empat pos pemadam kebakaran semuanya bertugas untuk mengamankan. Sedangkan untuk jarak jangkauan 2000 meter hanya 3 pos pemadam kebakaran yang bertugas. Jarak jangkauan 3000 meter, 2 pos pemadam kebakaran yang bertugas. Jarak jangkauan 4000-5000 meter hanya 1 pos pemadam kebakaran yang bertugas.
The effect of a warm compress of cinnamon on reducing pain in sufferers of arthritis gout
Authors: Cobalt Maya 
Published: March 2021

Background: One of the disorders experienced by gout arthritis sufferers is pain in the joints. Joint pain in patients with gouty arthritis occurs due to deposits of monosodiumuric crystals that accumulate in the joints as a result of high levels of gout arthritis in the blood. One of the interventions that can be given to reduce the pain scale in sufferers of gouty arthritis is the administration of warm cinnamon compresses. The essential oil in cinnamon bark contains eugenol, where eugenol has a very hot and spicy taste so it can open the skin's pores. So that pain can be reduced with the warm cinnamon compress.
Purpose: The effect of the warm cinnamon compress aims to determine the benefits of the warm cinnamon compress to reduce the pain scale in sufferers of gout arthritis.
Methods: This study used a quasi-experimental method with a pre and post control group approach. The sample in this study amounted to 50 respondents, the sample was taken by stratified random.
Results: The results of the Wilcoxon test showed that the p value in the control group was 0.850 and the intervention group obtained a p value of 0.000. The results of the Paired T-test showed that the p value in the control group was 0.594 and the intervention group obtained a p value of 0.000. Independent T-test results obtained p value 0.000 <0.05, meaning that there is an effect of warm cinnamon compresses on reducing pain in patients with gout arthritis before and after giving warm cinnamon compresses between the intervention group and the control group.
Conclusion: The warm cinnamon compress has an effect on reducing the pain scale in people with gouty arthritis.
Keywords: gout arthritis, pain, cinnamon warm compress
Silencing of OIP5-AS1 Protects Endothelial Cells From ox-LDL-Triggered Injury by Regulating KLF5 Expression via Sponging miR-135a-5p
Authors: Zhao Minghu , Yang Yuanyuan , Li Jingchao , Lu Min , Wu Yu 
Published: March 2021

Background: Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of atherosclerosis. LncRNA OIP5 antisense RNA 1 (OIP5-AS1) has been found to be associated with the development of atherosclerosis. In this study, we further investigated the molecular basis of OIP5-AS1 in atherosclerosis pathogenesis.Methods: Oxidative low-density lipoprotein (ox-LDL) was used to treat human umbilical vein endothelial cells (HUVECs). The levels of OIP5-AS1, miR-135a-5p, and Krüppel-like factor 5 (KLF5) were detected by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot. Cell viability, migration, and apoptosis were evaluated using the Cell Counting Kit-8 (CCK-8), Transwell, and flow cytometry, respectively. The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and malondialdehyde (MDA) were determined with enzyme-linked immunosorbent assay (ELISA). Targeted interactions among OIP5-AS1, miR-135a-5p, and KLF5 were confirmed by dual-luciferase reporter and RNA immunoprecipitation (RIP) assays. Animal studies were performed to assess the role of OIP5-AS1 in atherosclerosis progression in vivo.Results: Our data showed the significant upregulation of OIP5-AS1 in atherosclerosis serum and ox-LDL-stimulated HUVECs. The silencing of OIP5-AS1 protected against ox-LDL-triggered cytotoxicity in HUVECs and diminished lipids secretion in ApoE−/− mice. Moreover, OIP5-AS1 functioned as a molecular sponge of miR-135a-5p, and miR-135a-5p was a functional mediator of OIP5-AS1 in regulating ox-LDL-induced HUVEC injury. KLF5 was a direct target of miR-135a-5p, and the increased expression of miR-135a-5p alleviated ox-LDL-induced cytotoxicity by downregulating KLF5. Furthermore, OIP5-AS1 influenced KLF5 expression through sponging miR-135a-5p.Conclusion: The current work identified that the silencing of OIP5-AS1 protected against ox-LDL-triggered cytotoxicity in HUVECs at least in part by influencing KLF5 expression via acting as a miR-135a-5p sponge.
The Effect of 6 Months’ Treatment With Pasireotide LAR on Glucose Metabolism in Patients With Resistant Acromegaly in Real-World Clinical Settings
Authors: Witek Przemysław , Bolanowski Marek , Szamotulska Katarzyna , Wojciechowska-Luźniak Agnieszka , Jawiarczyk-Przybyłowska Aleksandra , Kałużny Marcin 
Published: March 2021

ObjectiveThe aim of the study was to evaluate glucose metabolism, as measured by glycated hemoglobin (HbA1c) levels and the need for antidiabetic medical treatment, in patients with acromegaly resistant to first-generation somatostatin receptors ligands (SRLs) treated with pasireotide long-acting release (LAR) in real-world clinical practice. Biochemical control of acromegaly, as measured by growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels, was also assessed.Study DesignTwo-center retrospective cohort of consecutive patients with acromegaly treated with first-generation SRLs at maximum doses, who had not achieved biochemical disease control. After SRLs were discontinued, patients were given pasireotide LAR 40 mg i.m. every 28 days. The dose was increased to 60 mg i.m. in patients for whom adequate control was not achieved after 3 months. Patients were given dietary and lifestyle advice, and antihyperglycemic treatment was modified as needed.Main Outcome MeasuresBiochemical disease control parameters (GH and IGF-1 concentration), as well as HbA1c level at baseline and after 6 months.ResultsIn total, 39 patients with acromegaly were enrolled. GH concentration decreased (Δme =-1.56 µg/L, range -21.38–3.62, p &lt;0.001) during 6 months of pasireotide LAR treatment. A worsening of metabolic status was observed, with an increase of median HbA1c (Δme =0.40%, range -0.20%–2.30%, p &lt;0.001), and antihyperglycemic treatment intensification in 23 (59.0%) patients. The median decline in IGF-1 concentration was: -283.0 µg/L, range -682.7–171.6, p &lt;0.001. IGF-1 reached the age- and gender-specific upper level of normal in 23 (59%) patients.ConclusionsPasireotide LAR is an effective therapeutic option in patients with acromegaly refractory to first-generation SRLs. However, this therapy may result in pasireotide LAR-associated hyperglycemia, which requires early and aggressive antidiabetic medical therapy to prevent glucose homeostasis alterations.
Metabolomic Signatures of Autoimmune Hepatitis in the Development of Cirrhosis
Authors: Li Shan-shan , Niu Ming , Jing Jing , Huang Ying , Zhang Zi-teng , Chen Shuai-shuai , Shi Ge-zi , He Xian , Zhang Hai-zhu , Xiao Xiao-he , Zou Zheng-sheng , Yu Yue-cheng , Wang Jia-bo 
Published: March 2021

Objectives: Autoimmune hepatitis (AIH) can progress into severe outcomes, i.e., decompensated cirrhosis, from remarkable and persistent inflammation in the liver. Considering the energy-expending nature of inflammation, we tried to define the metabolomics signatures of AIH to uncover the underlying mechanisms of cirrhosis development and its metabolic biomarkers.Methods: Untargeted metabolomics analysis was performed on sera samples from 79 AIH patients at the stages (phenotypes) of non-cirrhosis (n = 27), compensated cirrhosis (n = 22), and decompensated cirrhosis (n = 30). Pattern recognition was used to find unique metabolite fingerprints of cirrhosis with or without decompensation.Results: Out of the 294 annotated metabolites identified, 2 metabolic fingerprints were found associated with the development of cirrhosis (independent of the decompensated state, 42 metabolites) and the evolution of decompensated cirrhosis (out of 47 metabolites), respectively. The cirrhosis-associated fingerprints (eigenmetabolite) showed better capability to differentiate cirrhosis from non-cirrhosis patients than the aminotransferase-to-platelet ratio index. From the metabolic fingerprints, we found two pairs of metabolites (Mesobilirubinogen/6-Hydroxynicotinic acid and LysoPA(8:0/0:0)/7alpha-Hydroxycholesterol) calculated as ratio of intensities, which revealed robust abilities to identify cirrhosis or predict decompensated patients, respectively. These phenotype-related fingerprint metabolites featured fundamental energy supply disturbance along with the development of AIH cirrhosis and progression to decompensation, which was characterized as increased lipolysis, enhanced proteolysis, and increased glycolysis.Conclusions: Remodeling of metabolism to meet the liver inflammation-related energy supply is one of the key signatures of AIH in the development of cirrhosis and decompensation. Therefore, drug regulation metabolism has great potential in the treatment of AIH.
Hepatitis E 3ra Genotype Infection in People Living With HIV in Spain
Authors: Rivero-Juarez Antonio , Frias Mario , Lopez-Lopez Pedro , Berenguer Juan , García Federico , Macias Juan , Alcaraz Begoña , Castro-Iglesias Angeles , Caballero-Gomez Javier , Rivero Antonio 
Published: March 2021

BackgroundThe objective of our study was to assess the prevalence and incidence of HEV in people living with HIV (PLWH) in a Spanish national cohort.MethodsRetrospective longitudinal study including PLWH recruited in the cohort of adult HIV-infected patients of the AIDS Research Network in follow-up at 28 Spanish hospitals with available serum samples in 2014 and 2015. All samples were tested for HEV IgG, IgM, and RNA. Samples with detectable HEV viral loads were genotyped. Prevalence and incidence of HEV infection were calculated.ResultsThe study sample comprised 845 PLWH. At baseline, 101 patients were positive for HEV IgG antibodies (11.9%), none had HEV IgM antibodies, and 2 presented detectable HEV RNA (0.23%). Forty-two seroconverted for IgG, supposing a cumulative incidence of 5.7%. One subject was positive for IgM (0.13%), and 2 showed detectable HEV RNA (0.27%). One case was infected by the emergent HEV genotype 3ra.ConclusionOur study identifies one case of HEV 3ra genotype infection, the main host of which is rabbit, showing a potential zoonotic role of this emerging genotype in Spain.
Volumetric Quantitative Ablation Margins for Assessment of Ablation Completeness in Thermal Ablation of Liver Tumors
Authors: Sandu Raluca-Maria , Paolucci Iwan , Ruiter Simeon J. S. , Sznitman Raphael , de Jong Koert P. , Freedman Jacob , Weber Stefan , Tinguely Pascale 
Published: March 2021

BackgroundIn thermal ablation of liver tumors, complete coverage of the tumor volume by the ablation volume with a sufficient ablation margin is the most important factor for treatment success. Evaluation of ablation completeness is commonly performed by visual inspection in 2D and is prone to inter-reader variability. This work aimed to introduce a standardized approach for evaluation of ablation completeness after CT-guided thermal ablation of liver tumors, using volumetric quantitative ablation margins (QAM).MethodsA QAM computation metric based on volumetric segmentations of tumor and ablation areas and signed Euclidean surface distance maps was developed, including a novel algorithm to address QAM computation in subcapsular tumors. The code for QAM computation was verified in artificial examples of tumor and ablation spheres simulating varying scenarios of ablation margins. The applicability of the QAM metric was investigated in representative cases extracted from a prospective database of colorectal liver metastases (CRLM) treated with stereotactic microwave ablation (SMWA).ResultsApplicability of the proposed QAM metric was confirmed in artificial and clinical example cases. Numerical and visual options of data presentation displaying substrata of QAM distributions were proposed. For subcapsular tumors, the underestimation of tumor coverage by the ablation volume when applying an unadjusted QAM method was confirmed, supporting the benefits of using the proposed algorithm for QAM computation in these cases. The computational code for developed QAM was made publicly available, encouraging the use of a standard and objective metric in reporting ablation completeness and margins.ConclusionThe proposed volumetric approach for QAM computation including a novel algorithm to address subcapsular liver tumors enables precision and reproducibility in the assessment of ablation margins. The quantitative feedback on ablation completeness opens possibilities for intra-operative decision making and for refined analyses on predictability and consistency of local tumor control after thermal ablation of liver tumors.
ZNF213 Facilitates ER Alpha Signaling in Breast Cancer Cells
Authors: Yang Huijie , Lv Xulei , Li Xin , Mao Lanzhi , Niu Zhiguo , Wang Ting , Zhuang Ting , Huang Qingsong 
Published: March 2021

BackgroundBreast cancer is the most common women malignancy worldwide, while estrogen receptor alpha positive type accounts for two third of all breast cancers. Although ER alpha positive breast cancer could be effectively controlled by endocrine therapy, more than half of the cases could develop endocrine resistance, making it an important clinical issue in breast cancer treatment. Thus, decoding the detailed mechanism, which controls ER alpha signaling activation and ER alpha protein stability, is of great importance for the improvement of breast cancer therapy. Several zinc finger proteins were shown to mediate the ubiquitination process and modulate protein stability. Thus, we further explore the function of Zinc finger protein 213 on ER alpha protein stability and tamoxifen resistance.MethodsCCK8 and Edu assay was used to measure cell proliferation. RNA sequence was performed by Ingenuity pathway analysis. The ER alpha signaling activities were measured with luciferase assay, real-time quantitative PCR, and western blotting. Protein stability assay and ubiquitin assay were used to determine ER alpha protein degradation and ubiquitination. The immuno-precipitation was utilized to determine ER alpha and ZNF213 interaction. The ubiquitin-based immuno-precipitation assay was sued to detect specific ubiquitination manner on ER alpha.ResultsWe identified ZNF213 as a novel zinc finger protein, which modulated ER alpha protein. ZNF213 expression correlated with poor outcome in endocrine treated patients. ZNF213 depletion inhibited ER alpha signaling and proliferation in breast cancer cells. Further mechanistic studies showed ZNF213 located in cytosol and nuclear, which modulated ER alpha stability via inhibiting ER alpha K48-linked ubiquitination.ConclusionsOur study reveals an interesting post-translational mechanism between ER alpha and ZNF213 in breast cancer. Targeting ZNF213 could be an appealing strategy for ER alpha positive breast cancer.
Does education of primary care professionals promote patient self-management and improve outcomes in chronic disease? An updated systematic review
Authors: Collins Claire , Doran Gillian , Patton Patricia , Fitzgerald Roisin , Rochfort Andree 
Published: March 2021

BackgroundPrimary care has a vital role in supporting patient autonomy to enable people with long-term conditions to manage their own health and wellness. Evidence is needed on whether education and training of health professionals helps support patient self-management and improves outcomes. The authors' first systematic review included only two articles showing patient outcomes following health professional training for promoting patient self-management.AimTo present an updated review undertaken from September 2013 to August 2018.Design & settingA systematic review was undertaken using the PRISMA guidelines, following the methodology of the first review and is outlined in the PROSPERO registered protocol.MethodSix databases were searched — Cochrane Library, PubMed, ERIC, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PsycINFO — in addition to web searches, hand searches, and bibliographies for articles published from 1 September 2013 to 31 August 2018.ResultsThe updated systematic review showed more evidence is now available with 18 articles in the 5-year period from the 4284 abstracts located. Twelve of these articles showed a difference between intervention and control groups. Of the 18 articles identified, 11 were assessed as having a low risk of bias and five overall were rated of weak quality. The educational interventions with health professionals spanned a range of techniques and modalities, and many incorporated multiple interventions including patient components. There may be a lack of adoption owing to several challenges, including that complex interventions may not be delivered as planned and are difficult to assess, and owing to patient engagement and the need for ongoing follow-up.ConclusionMore high-quality research is needed on what methods work best, for which patients, and for what clinical conditions in the primary care setting. The practical implications of training healthcare professionals require specific attention.
Medical applicant general practice experience and career aspirations: a questionnaire study
Authors: Agravat Priyesh , Ahmed Tafsir , Goudie Esme , Islam Shahraz , McKechnie Douglas GJ , Abdirahman Haji Mohamed , Ahmed Mahnoor , Al-Balah Amer , Alam Ayesha , Amin Fahima , Beqiri Sara , Chakka Smruthy , Chisenga Katy , Goodka Roshni , Hafiz Nida , Kotamarthi Ankita , Olatunji Ayobami Emmanuel , Fyfe Molly V , Dutta Nina , McManus Ian Chris , Harrison David , Woolf Katherine 
Published: March 2021

BackgroundIncreasing access to general practice work experience placements for school students is a strategy for improving general practice recruitment, despite limited evidence and concerns surrounding equity of access to general practice experiences.AimsTo examine the association between undertaking general practice experience and the perceptions of general practice as an appealing future career among prospective medical applicants. To identify socioeconomic factors associated with obtaining general practice experience.Design & settingCross-sectional questionnaire study in the UK.MethodParticipants were UK residents aged ≥16 years and seriously considering applying to study medicine in 2019/2020. They were invited to take part via the University Clinical Aptitude Test (UCAT). Questionnaire data were analysed using a linear regression of general practice appeal on general practice experience, adjusting for career motivations and demographics, and a logistic regression of general practice experience on measures of social capital and demographics.ResultsOf 6391 responders, 4031 were in their last year of school. General practice experience predicted general practice appeal after adjusting for career motivation and demographics (b = 0.37, standard error [SE] = 0.06, P<0.00001). General practice experience was more common among students at private (odds ratio [OR] = 1.65, 95% confidence interval [CI] = 1.31 to 2.08, P<0.0001) or grammar schools (OR = 1.33, 95% CI = 1.02 to 1.72, P = 0.03) and in the highest socioeconomic group (OR = 1.62, 95% CI = 1.28 to 2.05, P<0.0001), and less likely among students of ‘other’ ethnicity (OR = 0.37, 95% CI = 0.20 to 0.67, P = 0.0011).ConclusionHaving general practice experience prior to medical school was associated with finding general practice appealing, which supports its utility in recruitment. Applicants from more deprived backgrounds were less likely to have had a general practice experience, possibly through lack of accessible opportunities.
ANALISIS HUBUNGAN KADAR GULA DARAH PUASA DENGAN KADAR KOLESTEROL HIGH DENSITY LIPOPROTEIN (HDL) PADA PASIEN DIABETES MELLITUS TIPE 2 DI RSUP SANGLAH
Authors: Jirna Nyoman 
Published: March 2021

Abstract
Diabetes mellitus (DM) is a group of metabolic diseases with characteristic hyperglycemia that happen by abnormal secretions of insulin, insulin action, or both. The condition of insulin resistance in DM type 2 cause abnormal lipid metabolism that indicated by increase or decrease levels of lipid fraction in plasma, include increase levels of Very Low Density Lipoprotein (VLDL) or triglycerides, decrease levels of High Density Lipoprotein (HDL), and formed small dense Low Density Lipoprotein (LDL). The purpose of this study is to determine the relationship between the fasting blood sugar levels with HDL cholesterol levels in patients with DM type 2. The method use an analytical study with cross sectional design. Sampling examined as many as 35 samples by purposive sampling. The relationship between fasting blood sugar levels with HDL cholesterol levels is analyzed by Pearson Product Moment Correlation test. Based on the result concluded that there is a relationship between fasting blood sugar levels with HDL cholesterol levels in patients with DM type 2 in RSUP Sanglah with significant value sig=0,030 (sig