bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Potato Almond Orange Cookies on their Weight, BMI, Hemoglobin, and Lymphocyte Status of Undernourished Older People during COVID-19 Pandemic
Authors: Fatmah  
Published: February 2021

Background:
Older people vulnerability to COVID-19 is related to the presence of comorbidities,
diseases, and low immunity. Undernutrition conditions make them prone to anemia
(low hemoglobin/Hb), and low lymphocyte level brings a higher risk for COVID-19 infection.

Objective:
To assess the effect of potato almond orange cookies on weight, Hb, and lymphocyte
levels of undernourished older people amidst the COVID-19 pandemic.

Methods:
This 3-week randomized controlled trial involved 48 subjects > 60 years, divided randomly
into treatment group (potato almond orange cookies) and control groups (potato almond
cookies). Lymphocyte and Hb were collected before and after the study. Both groups received
nutrition education. The analysis was performed using an independent t-test and paired t-test.

Results:
Weight gained in the treatment group (0.7 kg) was significantly different from the control
group (p=0.002), with a 0.3 point change observed in the BMI of the treatment group.
Changes were also seen in vitamin C intake in treatment group (+10.3 mg, p = 0.03) and vitamin
E intake in both groups (+4.6 mcg, p = 0.001 and +2.9 mcg, p = 0.001, respectively), but not for
inter-group. Weight, Hb, and lymphocyte level increased in both groups, with the highest weight
increased in the treatment group while the highest Hb increased in the control group. The lymphocyte
increased 1 point in both groups. Weight, Hb, and lymphocyte level differences were insignificant
between the two groups.

Conclusion:
Potato almond orange consumption tends to increase weight, Hb, and lymphocyte
level in undernourished older people during the COVID-19 pandemic.
Characterization of Therapeutic Targets from Aspergillus fumigates in response
to Adjunctive Combination Therapy (Ketoconazole with EDTA)
Authors: Ruhil Sonam , Kumar Vikash , Malik Monika , Balhara Meenakshi , Chhillar Anil Kumar 
Published: February 2021

Background:
The Kingdom (Fungi) comprises numerous species that are associated
with numerous fungal diseases. Moreover, the fungal resistance, stagnation in the development of
antifungal agents and unacceptably high mortality rate associated with some resistant fungus indicate
that alternative therapeutic options should be considered.

Objective:
The objective of this study was to find out new therapeutic targets of A.fumigatus in response
to adjunctive combination, i.e., Ketoconazole (KTZ) plus EDTA.

Methods:
A.fumigatus was cultured in the absence and presence of a sublethal dose (MIC 50) of
EDTA, KTZ and a combination of KTZ plus EDTA. The cytosolic proteins were extracted by mechanical
grinding of fungal cells. The protein profile was studied by using a proteomic approach
and the identification of protein was done by MALDI-TOF/MS. The morphological effect of the
combination on A. fumigatus was studied by Scanning Electron Microscopy (SEM) and toxic effect
on erythrocytes by haemolytic assay.

Result:
The combination of KTZ with EDTA was non-toxic up to 500 μg/ml by MTT assay. It inhibits
the expression of the following proteins: Glutamatedehydrogenase, Phenyl alanyl t-RNA synthetase
POD G, CaO19-5601, AN6454.2 (Conserved domain; MFS (Major Facilitator Superfamily),
serine/threonine-protein kinase and dipeptidyl peptidase (identified by peptide mass fingerprinting).
Some of these proteins are involved in hyphal development. Morphological defects on the development
of fungus (like disrupted hyphal tips, phialide) were observed.

Conclusion:
These targets can be used for novel drug development as some of them are involved
in fungal virulence, and adjunctive combination therapy can be an optimistic approach.
Acidic Pyridinium Inner Salt as a New, Effective and Reusable Catalyst for the One-Pot Three-Component Synthesis of N-substituted 5-aryl-4-benzoyl- 3-hydroxy-3-pyrrolin-2-ones in Aqueous Media
Authors: Shahnaei Roya , Kabirifard Hassan 
Published: February 2021

Background:
The present method is facile and effective for the synthesis of N-substituted
5-aryl-4-benzoyl-3-hydroxy-3-pyrrolin-2-one derivatives which are obtained by one-pot threecomponent
condensation reactions of aromatic aldehydes, primary amines and ethyl benzoylpyruvate
in the presence of a novel homogeneous catalyst including acidic pyridinium inner salt (PIS)
at 50°C in ethanol and water mixture as solvent.

Methods:
5-Aryl-4-benzoyl-3-hydroxy-3-pyrrolin-2-ones were synthesized through a one-pot three-
-component tandem formation of Schiff base cyclo condensation reaction of aromatic aldehydes,
primary amines and ethyl benzoylpyruvate in the presence of 10 mol% of acidic pyridinium inner
salt as a catalyst under aqueous ethanol medium at 50°C. All obtained structures were confirmed
by their elemental analysis data and IR, 1H NMR and 13C NMR spectroscopy.

Results:
Three-component synthesis of 5-aryl-4-benzoyl-3-hydroxy-3-pyrrolin-2-ones catalyzed by
acidic pyridinium inner salt with aromatic aldehydes, primary amines and ethyl benzoylpyruvate in
aqueous ethanol medium at 50°C was prepared. The achieved derivatives (eight entries) were well
synthesized in excellent yields.

Conclusion:
We found acidic pyridinium inner salt as a proper catalyst for this method. A catalyst’s
novelty is excellent catalytic activity, easy separation of the reaction mixture by washing with
cold water and reusability of the catalyst for six consecutive periods without disrupting the activity
of this catalyst system.
Programa cubano de pesquisa neonatal de la hiperplasia suprarrenal congénita: una realidad. 2005-2014
Authors: Carvajal Martínez Francisco , González Reyes Ernesto Carlos , Espinosa Reyes Tania , Frómeta Suárez Amarilys , Castells Martínez Elisa María , Arteaga Yera Ana Luisa , Pérez Moras Pedro Lucio 
Published: February 2021

Introducción: la hiperplasia suprarrenal congénita (HSC) es el desorden adrenal más común en la infancia y la causa más frecuente de ambigüedad sexual. La forma clásica, que representa los casos más severos de este déficit, se asocia en un 75 % con pérdida de sal. Por otra parte, en los recién nacidos (RN) del sexo femenino se pueden presentar grados severos de virilización de genitales.
Objetivo: presentar los resultados (durante diez años), del Programa Cubano de Pesquisa Neonatal (PN) de la HSC, soportado en un procedimiento inmunoenzimático desarrollado en Cuba.
Resultados: en el período de enero 2005 a diciembre 2014, se han estudiado 1 140 882 RN y se detectaron 56 niños con HSC, para una incidencia de 1:20 373 RN. La cobertura del programa se ha incrementado hasta llegar en el año 2013 al 99.34 % de todos los RN cubanos.
Conclusiones: la existencia del Programa Cubano de PN de HSC, ha permitido estimar la incidencia e incrementar el conocimiento de esta enfermedad. La PN ha posibilitado el diagnóstico precoz en la variedad perdedora de sal, contribuyendo a la disminución de la mortalidad infantil. El Programa ha favorecido a pacientes con formas virilizantes de la enfermedad, mediante la asignación correcta del sexo.
Transmisión Vertical del COVID-19: Revisión de 50 casos reportados
Authors: Pablo Tanya , Barreto Nicole 
Published: February 2021

Introducción: la enfermedad por coronavirus (COVID-19) se identificó como causa de un brote de enfermedad respiratoria en Wuhan, China, en diciembre 2019. Más allá del impacto del COVID-19 en la mujer embarazada, existen inquietudes sobre sus efectos en el resultado fetal y neonatal. El objetivo de esta revisión fue analizar literatura actual sobre este aspecto.
Materiales y método: se realizó una búsqueda exhaustiva en PubMed, usando una combinación de los términos: “COVID-19” y “vertical transmission”. Los criterios de elegibilidad fueron: casos publicados sobre el impacto del COVID-19 en el embarazo y su transmisión vertical, pacientes de 18 años o más, y cursando un embarazo en el segundo o tercer trimestre al momento del diagnóstico de la enfermedad, reportes publicados en inglés o español.
Resultados: trece estudios fueron incluidos según los criterios de elegibilidad. Un total de 50 pacientes embarazadas positivas para COVID-19 y 51 neonatos fueron estudiados. De los 51 neonatos, 7 obtuvieron resultados positivos; de los cuales 4 fueron de hisopado nasofaríngeo y 3 correspondieron a muestras de placenta y membranas fetales.
Conclusión: en esta revisión no encontramos evidencia definitiva que soporte la transmisión vertical de SARS-CoV-2 durante el segundo y tercer trimestre del embarazo.
Biotecnologie innovative per il trattamento avanzato delle acque reflue: i bioreattori anaerobici a membrane
Authors: Riccardi Laura Valentina 
Published: February 2021

Negli ultimi anni l’inquinamento ambientale rappresenta una tematica di
notevole rilievo, dal momento che la salute umana e l’equilibrio
dell’ecosistema si basano su una corretta gestione delle varie risorse.
In riferimento alle risorse idriche si evince come l’inquinamento delle
acque progredisca rapidamente, a causa della continua immissione di
sostanze inquinanti nei corpi idrici recettori. È per tale motivo che
assume particolare importanza gestire e trattare opportunamente le acque
reflue, in modo da poterle smaltire in totale sicurezza, così come
previsto dalla normativa vigente. A tal proposito sono state introdotte
nuove biotecnologie capaci di assicurare una resa depurativa maggiore,
ossia gli impianti MBR (Membrane Biological Reactor). I bioreattori a
membrana sono caratterizzati dalla combinazione dei processi di
degradazione biologica a fanghi attivi e della filtrazione su membrana.
Di recente, tra le varie configurazioni dei sistemi MBR, è stata posta
l’attenzione sui bioreattori a membrana operanti in condizioni
anaerobiche, in quanto consentono il recupero di biogas.
Pemanfaatan Alokasi Dana Desa Dalam Meningkatkan Perekonomian Masyarakat Desa Tunujungtirto Kecamatan Singosari Malang
Authors: Pramudiana Ika Devy , Sholichah Nihayatus 
Published: February 2021

Desa memiliki peran yang sangat penting dalam menyelenggarakan urusan pemerintahan umum desa serta pelayanan kepada masyarakat secara lebih terarah dan fokus terutama program kegiatan pemerintah desa yang bersentuhan langsung dengan kepentingan masyarakat desa. Dalam dana desa Tunjungtirto terbagi menjadi empat bagian yaitu perekonomian, sarana prasarana dasar, sarana dan prasarana pelayanan sosial dasar dan pemberdayaan. Dari empat bagian alokasi dana desa Alokasi di bidang ekonomi pada desa Tunjungtirto ini diharapkan mampu mensejahterakan masyarakatnya dan dalam rangka mengurangi kemiskinan di pedesaan karena penguatan basis ekonomi rakyat yang bersumber pada asset desa merupakan pilihan menuju kemandirian. Ada beberapa kesimpulan dari hasil penelitian ini yaitu pemanfaatan ADD pada bidang ekonomi masyarakat adalah tersedianya tempat penjualan berbagai hasil produksi rumah tangga masyarakat Desa Tunjungtirto, dan juga dengan ADD di bidang ekonomi di gunakan untuk kegiatan peningkatan peranan wanita melalui perwujudan kesetaraan gender dan Pemberdayaan dan Kesejahteraan Keluarga (PKK) Desa.
Implementasi Kebijakan PTSL (Pendaftaran Tanah Sistematis Lengkap) Di Desa Medaeng Kecamatan Waru Kabupaten Sidoarjo
Authors: Lika Sari Dewi Rambu , Sholichah Nihayatus 
Published: February 2021

Berdasarkan kebutuhan masyarakat atas tanah dan rumah yang semakin hari makin meningkat Adanya Pendaftaran tanah sistematis lengkap (PTSL) di kantor pertanahan dapat menyelenggarakan tugas-tugas pertanahan dimanapun target kegiatannya berada. Tujuan penelitian ini untuk mengetahui pelaksanaan kebijakan PTSL (pendaftaran tanah sistematis lengkap ) dan untuk mengetahui faktor- faktor yang mempengaruhi pelaksanaan kebijakan PTSL( pendaftaran tanah sistematis lengkap) di Waru kabupaten Sidoarjo. Penelitian ini menggunakan penelitian deskriptif kualitatif. Hasil penelitian menunjukan bahwa pelaksanaan kebijakan program pendaftaran tanah sistematis lengkap (PTSL) di Waru Kabupaten Sidoarjo di Desa Medaeng untuk saat ini baru pada tahap pendaftaran. Sehingga belum bisa dikatakan bahwa implementasi kegiatan Pelaksanaan kebijakan PTSL (pendaftaran tanah sistematis lengkap ) ini berhasil atau tidak karena masih di tahap pendaftaran dan faktor-faktor yang mempengaruhi pelaksanaan kebijakan PTSL (pendaftaran tanah sistematis lengkap) di Waru Kabupaten Sidoarjo yaitu faktor pendukung yang terdiri atas struktur birokrasi. Sedangkan faktor penghambatnya adalah komunikasi (Communications) dan sikap (dispositions atau attitudes).
Aksi Masyarakat Peduli Sanitasi Dalam Mewujudkan Kampung Hijau Di Cempaka Putih, Jakarta Pusat
Authors: Aziz Yugni Maulana , Setiawan Naufal Muzaki , Hikmawan M. Dian 
Published: February 2021

DKI Jakarta setiap hari memproduksi 7000 ton sampah, hal itu merupakan masalah lingkungan yang perlu ditangani secara serius karena berdampak pada semua sektor. Kampung Hijau berseri menjadi salah satu kampung percontohan bagi masyarakat Jakarta Pusat sebagai kampung pengurangan sampah dari Pemprov DKI Jakarta karena kegiatan yang di lakukan warganya berusaha mengurangi jumlah sampah yang di setor ke TPA (Tempat Pembuangan Akhir). AMPUTASI (Aksi Masyarakat Peduli Sanitasi) melakukan gerakan bersama masyarakat Kampung Hijau Berseri untuk melakukan tindakan nyata mengurangi hasil produksi sampah Jakarta dengan cara memilah sampah organic dan non organic. Penelitian ini dilakukan di Kampung Hijau Berseri dengan menggunakan teknik wawancara dan observsi. Jenis penelitian yang di gunakan dalam penelitian ini menggunakan metode kualitatif. Penelitian ini menemukan gerakan AMPUTASI mengurangi jumlah sampah dengan cara membuat sampah lebih memiliki nilai ekonomis.
Distributed Generation system Power Enhancement by per phase Converter and Differential Evolutionary Optimization Controller
Authors: Tiwari Pawan Kumar , Upadhyay Mrs. Madhu 
Published: February 2021

Worldwide renewable energy resources, especially solar energy, are growing dramatically in view of energy shortage and environmental concerns. The main objective of this study the design of a solar photovoltaic system in MATLAB/SIMULINK environment so as to enhance its output capacity before its integration with the grid. And to stabilize and improve the active power output from the solar system by designing an efficient controller for the inverter for DC to AC conversion based on AI optimization technique. Enhance the system reliability and efficiency by integrating it with the grid via a transformer with the desired grid voltage and frequency and studying its performance at different loads.
This work provides a comprehensive design and implementation of power regulatory per phase inverter with proposed differential evolutionary pulse regulation control. Finally the work is made efficiently integrating it with the grid. The designed system is also capable of feeding reactive power to the grid when required. The computational methodology of the proposed modulation technique is very easy and the technique can be applied to the multilevel inverter with any number of levels.
MYTHOLOGICAL SYMBOLS FROM THE THRACIAN MEGALITHIC SANCTUARIES, CHRISTIAN AND MUSLIM SACRED PLACES ON THE BALKANS
Authors: Markov Vassil 
Published: February 2021

Abstract: The ancient Thracian megalithic and stone-hewn sacred places are full of symbols closely connected with the Thracian mythology and ancient cult practices which were typical for this area. Among them the most numerous are the huge stone-hewn human footprints, which in Bulgarian folklore were regarded as the footprints of the hero Krali Marko, who was thought of as the guardian of the people in Bulgaria. In the contemporary science studying Thrace he is believed to have been the folklore successor of the Thracian Dionysus.Marking the sacred place with a stone-hewn footstep altar of the hero was authentic evidence for the believers in ancient times that the god had been there in primordial mythological times. In this way, through the contact with the divine, the monumental rock turns into sacred and the place turns into a sanctuary. The raw becomes boiled, Nature becomes culture. With the establishment of Christianity as the sole religion in the Roman Empire since the 4th century, some of the Thracian megalithic sanctuaries have been abandoned. Others have been Christianized. Later, others in the Middle Ages were converted into Islamic sacred places. In this way they became permanently sacred places on the Balkans. Part of the signs-symbols in them have a new meaning in the spirit of the new religions.Key words: anthropology; history of culture; religion; mythology; archaeology;
Europejskie programy GNSS na rynku globalnych systemów nawigacyjnych
Authors: Warcholik Witold 
Published: February 2021

The study includes the description of development conditions for the satellite navigation programme Galileo. Its also includes some aspects of the Galileo programme accomplishment, especially its influence on the integration process in Europe and tightening the international connections. The programme has been implemented since the 1990s and its aim is to ensure the independence of the EU countries in such sectors of their economy which are based on the precise information related to location and time. Galileo has also its overregional dimension, which is the result of satellite constellation and its global reach. It is the biggest industrial project conducted within the integrated European structures. What is more, the distinction of Galileo among other European satellite programmes has its roots in its crucial strategic significance rather than in technology or investment costs. So far, the cosmologic institutions have not been formally connected with the integrated European structures, and less importance has been attached to political aspects of their projects. The transformation of the Galileo programme is proceeding in the condition of potential incomes risk from the system work. The fiasco of public and private partnership establishments was the result of differences in estimating the risk of trade incomes and market development. In 2013 Galileo will be in its full operation process and first GPS III satellites will work, what is more, the high precision of this American system and other integrated GNSS systems will establish competition in terms of commercial and amateur aplications. Widening the cooperation between the EU countries and the USA implies many positive effects, such as creating the idea of a multi-system satellite scheme, the compatibility of Galileo and GPS receivers and, what follows, the increase of navigation precision and reduction of overall costs borne by the system owners.
Wpływ globalizacji i integracji w ramach MERCOSUR na wymianę handlową produktów przemysłu samochodowego Brazylii w latach 1990–2006
Authors: Wójtowicz Mirosław 
Published: February 2021

The aim of this paper is determining the influence of the globalization and regional integration processes on the Brazilian automobile industry. The paper also contains the analysis of changes in the state’s industrial policy towards this sector and their influence on winning new foreign investments. The analysis also concerns changes in the MERCOSUR integration policy towards the automobile industry. It was observed that the changes that occurred in the Brazilian automobile industry in the years 1990–2006 are to a large extent a consequence of world-wide transformations in the sector, caused by globalization. On one hand, the changes consisted in modernizing the existing plants, and on the other hand – in emergence of completely new enterprises that aimed at global expansion on the so-called rising markets. This led to the increase in production, diversification of the assortment of available models, and the increase in competition on the Brazilian market.As for integration policy, the member states tried to postpone as long as possible complete liberalization of products trade in this industry within MERCOSUR. Owing to this, they were able to conduct individual policies in this sector, on one hand trying to maintain the barriers that protected their domestic markets, and on the other hand, trying to offer as much as possible to attract foreign investors. This led to numerous conflicts and great tension, chiefly between Argentina and Brazil, which endangered the process of economic integration. Still, the emerging problems were successfully overcome and the barriers for automobile industry trade within MERCOSUR were gradually eliminated. It was reflected in the rapid increase in car trade between the two countries in years 2003–2006.
Wpływ procesów globalizacji i integracji europejskiej na przekształcenia struktur polskiego przemysłu cukrowniczego
Authors: Niemczak Marcin 
Published: February 2021

The problem of economic transformation, and especially of structural transformations of industries in view of globalization and European integration becomes particularly significant. One of the most important effects of globalization, vital in modernization of economy, is restructuring of industry. This process requires precise recognition of the mechanisms of its functioning and identification and employment of these mechanisms in the process of adapting countries’ economies to the new, competitive conditions of the global economy.Such actions are indispensable to increase the competitiveness of products and services provided by enterprises.In the period of transformation, functioning of the Polish sugar industry depended not only on the current socio-economic conditions, but also on the influence of integration processes. As economic transformation, especially restructuring of enterprises, is strictly connected with great financial expenditure and with changes in the system of management, it had an effect on the course of transformations in the spatial structure of the Polish sugar industry
Koncentracja przestrzenna światowych firm informatycznych
Authors: Kilar Wioletta 
Published: February 2021

The article analyses the spatial concentration of world IT companies. They have been described in terms of their varied potential, types and extent of activity and the degree of global concentration. Research included the world’s top 100 largest IT companies, which jointly receive a revenue of USD 1.2 trillion, turning a profit of USD 140 billion. The revenue of the different companies ranged from USD 524.7 million to USD 97.0 billion. The leaders among those businesses are IBM Corporation, Verizon Communications, Deutsche Telekom and Samsung Electronics, which concentrate USD 313.0 billion, that is 25.9 per cent of the total revenue that the largest IT corporations receive. The joint profit of all the analysed IT companies is USD 140.1 billion and it ranges from USD 12.4 million to 11.2 billion. The corporations that make the highest profit are Microsoft, Samsung Electronics and IBM, which jointly earn USD 28.9 billion, which makes up 20.6 per cent of total profit. The analysed corporations are marked by a strong correlation between the revenue and profit ─ its index is 0.832.The analysed enterprises represent 8 types of business in the IT sector: telecommunication, hardware, software, semiconductors, telecommunication devices, services, distributors and Internet companies. The leaders among them are 24 telecommunication companies, whose joint revenue is USD 428.2 billion, that is 35.4 per cent of the total income, and the profit is USD 46.5 billion, that is 33.2 per cent of total profit.The United States has a high concentration of IT companies, 44 of which have reached 43.4 per cent of total revenue and 49.7 per cent of total profit. Companies located in Korea, Germany and Taiwan yield very high revenue and profit. Sixty-three companies from those four countries jointly yield USD 805.7 billion, that is 66.6 per cent of revenue, and USD 94.5 billion, that is 67.5 per cent of total profit. The least important in this respect are the companies located in Switzerland, the Cayman Islands, Turkey, the Netherlands, New Zealand and Indonesia, which jointly concentrate USD 22.5 billion, that is 1.9 per cent of revenue and USD 2.7 billion, that is 1.9 per cent of total profit.