bluuebunny/crossref_metadata_2025_split huggingface dataset:
Еко-маркетинг і його організаційно-інноваційний розвиток у харчовій індустрії
Authors: Мних Ольга , Камілевська Ольга 
Published: March 2021

Анотація. Визначено та обґрунтовано якісне функціональне навантаження еко-маркетингу підприємств харчової індустрії з врахуванням сучасних викликів щодо екологічної чистоти довкілля, погіршення якості життя суспільства та обмежених ресурсних можливостей економічних агентів. Розглянуто змістовну характеристику еко-маркетингу у науковій літературі. Виявлено практичні підходи урядових і корпоративних структур щодо рефлексивного маркетингу, а також тренди щодо трансформації класичного маркетингу в еколого-соціо-орієнтований, проведено аналіз зростаючої цінності трансферу еко-технологій та інновацій для зменшення відходів виробництва і логістики у харчовій індустрії. Дано узагальнений аналіз закордонної і вітчизняної практики впровадження концепції екологічного маркетингу і визначено бар’єри та обмеження на шляху її реалізації. Розроблено концептуальну схему еко-маркетингу, як нового стратегічного мислення менеджменту. Акцентовано увагу на зміцнення власного потенціалу еко-маркетингу у діяльності кожного ринкового суб’єкта у ланцюгу створення суспільної цінності і використання сучасних біотехнологій та цифрових технологій у виробництві та в управлінні факторами впливу на поведінку екологічно свідомих споживачів. Запропоновано схематичну модель взаємозв’язків у системі інформаційного забезпечення еко-маркетингу у харчовій індустрії у відповідному інституційному середовищі, проведено обґрунтування економічної і маркетингової стратегії партнерства. Презентовано отримані результати кластерного і регресійного аналізу на прикладі підприємств молочної індустрії. Доведено, що еко-маркетинг повинен відігравати двояку роль у суспільстві: примножувати суспільні цінності новостворюваного продукту та зменшувати тиск на навколишнє середовище, що відкриває нові горизонти для ділової інтелектуальної та довготривалої співпраці.
Ключові слова: інновації, еко-маркетинг, еко-технологія, партнерство, інституційне середовище, екологічний аудит, харчова індустрія, трансфер еко-технології, кластерне утворення, сталий розвиток.
Фрактальні властивості управлінської ефективності як підґрунтя прогнозування комбінованих стратегічних сценаріїв розвитку машинобудівних підприємств на основі процесів диверсифікації та інтеграції
Authors: Прохорова Вікторія , Залуцька Христина 
Published: March 2021

Анотація. Для вибору найдоцільнішого методу прогнозування рівня розвитку підприємства залежно зміни умов його функціонування варто здійснити фрактальний аналіз, який дозволить визначити характер і причини зміни часового ряду результативності підприємства, що сприятиме підвищенню управлінської ефективності за рахунок прийнятих управлінських рішень адекватним сучасним умовам розвитку.
Метою статті є визначення фрактальних властивостей управлінської ефективності як підґрунтя прогнозування комбінованих стратегічних сценаріїв розвитку машинобудівних підприємств на основі процесів диверсифікації та інтеграції.
У роботі зроблено фрактальний аналіз рівня раціоналізації бізнес-процесів підприємства-репрезентанта (коефіцієнта синхронності) як основи забезпечення результативності показника його управлінської ефективності протягом 2009–2018 рр. Для аналізу таких часових рядів було використано метод Гарольда Едвіна Херста (R/S-аналіз). Метод Херста дозволяє проаналізувавши часові ряди, розрізнити випадкові та фрактальні часові ряди, а також зробити висновки щодо наявності неперіодичних циклів, довготривалої пам’яті та ін. Фрактальний аналіз коефіцієнта синхронності підприємства-репрезентанта, яке належить до кластера з високим рівнем розвитку, дав змогу визначити, що досліджуваний ряд є персистентним і, відповідно, подальшою тенденцією зміни цього показника буде зростання. Для зменшення значення коефіцієнта синхронності, яке свідчить про зростання незбалансованості наявних на підприємстві бізнес-процесів, що призводить до втрати можливості нарощення додаткового ефекту, необхідного для стратегічного розвитку підприємства в сучасних умовах функціонування, запропоновано управлінські рішення щодо використання диверсифікаційно-інтеграційного напрямку розвитку. Проведені розрахунки доцільності застосування обраного напрямку розвитку для зниження коефіцієнта синхронності підтвердили ефективність управлінських рішень.
Ключові слова: фрактальний аналіз; управлінська ефективність; диверсифікаційно-інтеграційний розвиток; коефіцієнт синхронності; прогнозування; машинобудівне підприємство.
Strategic Communication and Neuromarketing in the Fisheries Sector: Generating Ideas From the Territory
Authors: Russo Vincenzo , Milani Marin Laura E. , Fici Alessandro , Bilucaglia Marco , Circi Riccardo , Rivetti Fiamma , Bellati Mara , Zito Margherita 
Published: March 2021

Background: Globalization and technological progress has changed the relationships among fisheries, society and markets. The industrial primacy has led, among others, to the marginalization of fishermen and the deletion of local culture. It followed a loss of the conventional link between territory and traditions, with a change in consumer behavior.Aim: The purpose of this study is to investigate the way through which the communication of territoriality of fish products influences the consumers' quality perception, their willingness to pay and the exploration of packaging, in the Italian context.Method: In order to obtain quantitative and qualitative data on visual paths (the series of fixations and saccades) and areas of interest (AOI) of the analyzed packaging, gaze data were recorded. AOI permits to define regions of a visual stimulus and to link eye-movement measures to parts of the used stimulus. This study used AOI in order to measure Spent Time (the amount of time that consumers have spent looking at a particular AOI) and Entry Time (the time passed from the moment of the first fixation in a particular AOI) on brands and on products.Results: The results of the drivers identified crucial points for the future communication of fish products and the promotion of the territory. In particular, the analysis lays the foundations for a reorganization of the approach to the creation of product packaging, through greater attention to detail and the intrinsic values that this can express.Conclusion: The use of neuromarketing techniques has proved to be valid in identifying what is the main information that is processed for the evaluation of the product also considering the role played by emotions.
TRIB3 Promotes the Malignant Progression of Bladder Cancer: An Integrated Analysis of Bioinformatics and in vitro Experiments
Authors: Yang Jieping , Lin Jiaxing , An Jun , Zhao Yongkang , Jing Siyang , Yu Meng , Zhu Yuyan , Yao Yang 
Published: March 2021

BackgroundBladder cancer is a common malignant tumor characterized by high mortality and high management costs; however, it lacks useful molecular prognostic markers. Tribbles pseudokinase 3 (TRIB3) is a pseudokinase that participates in cell tumor progression and metabolism and whose function in bladder cancer is not precisely known.Main MethodsWe downloaded transcriptome data and clinical data of bladder cancer from associated databases and extracted the expression matrix of TRIB3 for multiple bioinformatics analysis. RT-PCR detected the expression of TRIB3 in bladder cancer cells. After knockdown of TRIB3 with siRNA, we investigated TRIB3 function using CCK8, Cell Cycle and Transwell assays.Key FindingsKaplan–Meier analysis of TRIB3 in the four cohorts showed that high expression of TRIB3 correlated with poor outcome. Expression of TRIB3 positively correlated with stage and grade and down-regulation of TRIB3 expression significantly inhibited proliferation, migration and cell cycle of bladder cancer cells.SignificanceTRIB3 is a potential prognostic marker and therapeutic target. It can be used to individualize the treatment of bladder cancer.
Plasmacytoid Dendritic Cells Depletion and Elevation of IFN-γ Dependent Chemokines CXCL9 and CXCL10 in Children With Multisystem Inflammatory Syndrome
Authors: Caldarale Francesca , Giacomelli Mauro , Garrafa Emirena , Tamassia Nicola , Morreale Alessia , Poli Piercarlo , Timpano Silviana , Baresi Giulia , Zunica Fiammetta , Cattalini Marco , Moratto Daniele , Chiarini Marco , Cannizzo Elvira Stefania , Marchetti Giulia , Cassatella Marco Antonio , Taddio Andrea , Tommasini Alberto , Badolato Raffaele 
Published: March 2021

BackgroundSARS-CoV-2 occurs in the majority of children as COVID-19, without symptoms or with a paucisymptomatic respiratory syndrome, but a small proportion of children develop the systemic Multi Inflammatory Syndrome (MIS-C), characterized by persistent fever and systemic hyperinflammation, with some clinical features resembling Kawasaki Disease (KD).ObjectiveWith this study we aimed to shed new light on the pathogenesis of these two SARS-CoV-2-related clinical manifestations.MethodsWe investigated lymphocyte and dendritic cells subsets, chemokine/cytokine profiles and evaluated the neutrophil activity mediators, myeloperoxidase (MPO), and reactive oxygen species (ROS), in 10 children with COVID-19 and 9 with MIS-C at the time of hospital admission.ResultsPatients with MIS-C showed higher plasma levels of C reactive protein (CRP), MPO, IL-6, and of the pro-inflammatory chemokines CXCL8 and CCL2 than COVID-19 children. In addition, they displayed higher levels of the chemokines CXCL9 and CXCL10, mainly induced by IFN-γ. By contrast, we detected IFN-α in plasma of children with COVID-19, but not in patients with MIS-C. This observation was consistent with the increase of ISG15 and IFIT1 mRNAs in cells of COVID-19 patients, while ISG15 and IFIT1 mRNA were detected in MIS-C at levels comparable to healthy controls. Moreover, quantification of the number of plasmacytoid dendritic cells (pDCs), which constitute the main source of IFN-α, showed profound depletion of this subset in MIS-C, but not in COVID-19.ConclusionsOur results show a pattern of immune response which is suggestive of type I interferon activation in COVID-19 children, probably related to a recent interaction with the virus, while in MIS-C the immune response is characterized by elevation of the inflammatory cytokines/chemokines IL-6, CCL2, and CXCL8 and of the chemokines CXCL9 and CXL10, which are markers of an active Th1 type immune response. We believe that these immunological events, together with neutrophil activation, might be crucial in inducing the multisystem and cardiovascular damage observed in MIS-C.
High Incidence of Epileptiform Potentials During Continuous EEG Monitoring in Critically Ill COVID-19 Patients
Authors: Schultz Barbara , Krauß Terence , Schmidt Maren , Schultz Michael , Schneider Andrea , Wiesner Olaf , Schmidt Julius J. , Stahl Klaus , David Sascha , Hoeper Marius M. , Busch Markus 
Published: March 2021

Objective: To analyze continuous 1- or 2-channel electroencephalograms (EEGs) of mechanically ventilated patients with coronavirus disease 2019 (COVID-19) with regard to occurrence of epileptiform potentials.Design: Single-center retrospective analysis.Setting: Intensive care unit of Hannover Medical School, Hannover, Germany.Patients: Critically ill COVID-19 patients who underwent continuous routine EEG monitoring (EEG monitor: Narcotrend-Compact M) during sedation.Measurements and Main Results: Data from 15 COVID-19 patients (11 men, four women; age: 19–75 years) were evaluated. Epileptiform potentials occurred in 10 of 15 patients (66.7%).Conclusions: The results of the evaluation regarding the occurrence of epileptiform potentials show that there is an unusually high percentage of cerebral involvement in patients with severe COVID-19. EEG monitoring can be used in COVID-19 patients to detect epileptiform potentials.
The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey
Authors: Rainero Innocenzo , Bruni Amalia C. , Marra Camillo , Cagnin Annachiara , Bonanni Laura , Cupidi Chiara , Laganà Valentina , Rubino Elisa , Vacca Alessandro , Di Lorenzo Raffaele , Provero Paolo , Isella Valeria , Vanacore Nicola , Agosta Federica , Appollonio Ildebrando , Caffarra Paolo , Bussè Cinzia , Sambati Renato , Quaranta Davide , Guglielmi Valeria , Logroscino Giancarlo , Filippi Massimo , Tedeschi Gioacchino , Ferrarese Carlo ,   the SINdem COVID-19 Study Group
Published: March 2021

IntroductionPrevious studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of quarantine for COVID-19 pandemic in patients with dementia are unknown. We investigated the clinical changes in patients with Alzheimer’s disease and other dementias, and evaluated caregivers’ distress during COVID-19 quarantine.MethodsThe study involved 87 Italian Dementia Centers. Patients with Alzheimer’s Disease (AD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementia (FTD), and Vascular Dementia (VD) were eligible for the study. Family caregivers of patients with dementia were interviewed by phone in April 2020, 45 days after quarantine declaration. Main outcomes were patients’ changes in cognitive, behavioral, and motor symptoms. Secondary outcomes were effects on caregivers’ psychological features.Results4913 patients (2934 females, 1979 males) fulfilled the inclusion criteria. Caregivers reported a worsening in cognitive functions in 55.1% of patients, mainly in subjects with DLB and AD. Aggravation of behavioral symptoms was observed in 51.9% of patients. In logistic regression analysis, previous physical independence was associated with both cognitive and behavioral worsening (odds ratio 1.85 [95% CI 1.42–2.39], 1.84 [95% CI 1.43–2.38], respectively). On the contrary, pandemic awareness was a protective factor for the worsening of cognitive and behavioral symptoms (odds ratio 0.74 [95% CI 0.65–0.85]; and 0.72 [95% CI 0.63–0.82], respectively). Approximately 25.9% of patients showed the onset of new behavioral symptoms. A worsening in motor function was reported by 36.7% of patients. Finally, caregivers reported a high increase in anxiety, depression, and distress.ConclusionOur study shows that quarantine for COVID-19 is associated with an acute worsening of clinical symptoms in patients with dementia as well as increase of caregivers’ burden. Our findings emphasize the importance to implement new strategies to mitigate the effects of quarantine in patients with dementia.
Factors Associated With the Dilation of Perivascular Space in Healthy Elderly Subjects
Authors: Huang Peiyu , Zhu Zili , Zhang Ruiting , Wu Xiao , Jiaerken Yeerfan , Wang Shuyue , Yu Wenke , Hong Hui , Lian Chunfeng , Li Kaicheng , Zeng Qingze , Luo Xiao , Xu Xiaopei , Yu Xinfeng , Yang Yunjun , Zhang Minming 
Published: March 2021

Background: The dilation of perivascular space (PVS) has been widely used to reflect brain degeneration in clinical brain imaging studies. However, PVS characteristics exhibit large differences in healthy subjects. Such variations need to be better addressed before PVS can be used to reflect pathological changes. In the present study, we aim to investigate the potential influence of several related factors on PVS dilation in healthy elderly subjects.Methods: One-hundred and three subjects (mean age = 59.5) were retrospectively included from a prospectively collected community cohort. Multi-modal high-resolution magnetic resonance imaging and cognitive assessments were performed on each subject. Machine-learning based segmentation methods were employed to quantify PVS volume and white matter hyperintensity (WMH) volume. Multiple regression analysis was performed to reveal the influence of demographic factors, vascular risk factors, intracranial volume (ICV), major brain artery diameters, and brain atrophy on PVS dilation.Results: Multiple regression analysis showed that age was positively associated with the basal ganglia (BG) (standardized beta = 0.227, p = 0.027) and deep white matter (standardized beta = 0.220, p = 0.029) PVS volume. Hypertension was positively associated with deep white matter PVS volume (standardized beta = 0.234, p = 0.017). Furthermore, we found that ICV was strongly associated with the deep white matter PVS volume (standardized beta = 0.354, p &lt; 0.001) while the intracranial artery diameter was negatively associated with the deep white matter PVS volume (standardized beta = −0.213, p = 0.032).Conclusions: Intracranial volume has significant influence on deep white matter PVS volume. Future studies on PVS dilation should include ICV as an important covariate.
Clinical and Prognostic Analysis of Autoantibody-Associated CNS Demyelinating Disorders in Children in Southwest China
Authors: Li Ziyan , Sun Hong , Fan Xiao , Yuan Ping , Jiang Yan , Wu Peng , Zhong Min , Ma Jiannan , Jiang Li , Li Xiujuan 
Published: March 2021

Objective: To analyze the positive and recurrence rates of different autoantibody-associated demyelination disorders in children in Southwest China, and describe the clinical, radiological, and prognostic features of the myelin oligodendrocyte glycoprotein antibody (MOG-ab) and aquaporin-4 antibody (AQP4-ab) associated disease. This study also summarizes steroid maintenance therapy approaches for MOG-ab-positive children.Methods: A total of 160 children presenting with acquired demyelinating syndromes (ADS) between January 2016 and December 2019 were tested for MOG-ab and AQP4-ab. Clinical data, MRI scans, and survival analyses were compared between MOG-ab-positive and AQP4-ab-positive children. Evolution of serologic status and treatment response to immunosuppressants were collected in MOG-ab-positive children.Results: Of the 160 included children, the MOG-ab positivity rate (47.4%) was significantly higher than the AQP4-ab (5%) positivity rate. The recurrence rate for AQP4-ab disease (71.4%) was higher than that of MOG-ab disease (30.1%). For 135 children with both MOG-ab and AQP4-ab tested, the median age at onset was 7 (interquartile range [IQR] 5–10) years, and the median follow-up period was 19 (IQR 13–27.5) months. MOG-ab-positive children more frequently presented with acute disseminated encephalomyelitis, had deep gray matter lesions on MRI, had a better clinical and radiological recovery, and were less likely to have sustained disability than AQP4-ab-positive children. In MOG-ab-positive and AQP4-ab-positive children, maintenance therapy was a protective factor for recurrence, but presenting optic neuritis was a predictor of earlier relapse. A high Expanded Disability Status Scale score at onset was associated with sustained disability. Steroid maintenance therapy longer than 6 months after the initial attack was associated with a lower risk of a second relapse in MOG-ab-positive children. On serial serum MOG antibody analysis, clinical relapse occurred in 34.6% of children with persistent seropositivity, but none of the children who converted to seronegative status experienced relapse.Conclusion: The MOG antibody is more common in children with ADS than the AQP4 antibody. MOG-ab-positive children are characterized by distinct clinical and radiological features. Although some MOG-ab-positive children experience relapsing courses or have persistently seropositive status, they still predict a better outcome than AQP4-ab-positive children.
Ultra-Processed Food Consumption Among Chilean Preschoolers Is Associated With Diets Promoting Non-communicable Diseases
Authors: Araya C. , Corvalán C. , Cediel G. , Taillie L. S. , Reyes M. 
Published: March 2021

Introduction: In adults, intake of ultra-processed foods (UPF) has been linked with poor diets and adverse health outcomes. In young children, evidence is scarcer but suggests a higher dietary share of UPF.Objective: To quantify the intake of UPF and its association with the nutrient composition of the diet in a sample of preschoolers in Santiago, Chile.Methods: Cross-sectional analysis of dietary data (24-h recall survey) from 960 preschoolers. Foods were categorized according to the extent and purpose of processing (NOVA classification) and participants were classified in quintiles of UPF intake. We explored the associations between UPF intake (% of the total energy) and intake of nutrients of concern for non-communicable disease development (carbohydrates, total sugars, fats, and sodium), and nutrients for promotion (proteins, polyunsaturated fats, iron, calcium, zinc, vitamins A, D, C, and B12, folate, and fiber) using multivariate regression after controlling for covariates.Results: UPF constituted 49% of the total energy intake. Preschoolers with higher intake consumed more energy, saturated and monounsaturated fats, carbohydrates, total sugars, and vitamin D, compared to preschoolers in the lowest quintile of UPF intake. In contrast, UPF intake was negatively associated with the consumption of proteins, polyunsaturated fats, fiber, zinc, vitamin A, and sodium (p &lt; 0.05).Conclusion: In Chilean preschoolers, UPF was the primary source of energy intake. The dietary share of UPF was associated with the nutrient composition of the diet. Improving children's diet should consider not only promoting healthy food consumption but also limiting UPF consumption.
The Spectrum, Tendency and Predictive Value of PIK3CA Mutation in Chinese Colorectal Cancer Patients
Authors: Fu Xinhui , Lin Hanjie , Fan Xinjuan , Zhu Yaxi , Wang Chao , Chen Zhiting , Tan Xiaoli , Huang Jinglin , Cai Yacheng , Huang Yan 
Published: March 2021

BackgroundPIK3CA is a high-frequency mutation gene in colorectal cancer, while its prognostic value remains unclear. This study evaluated the mutation tendency, spectrum, prognosis power and predictive power in cetuximab treatment of PIK3CA in Chinese CRC cohort.MethodsThe PIK3CA exon 9 and 20 status of 5763 CRC patients was detected with Sanger sequencing and a high-resolution melting test. Clinicopathological characteristics of 5733 patients were analyzed. Kaplan-Meier method and nomogram were used to evaluate the overall survival curve and disease recurrence, respectively.ResultsFifty-eight types of mutations in 13.4% (771/5733) of the patients were detected. From 2014 to 2018, the mutation rate of PIK3CA increased from 11.0% to 13.5%. At stage IV, exon 20 mutated patients suffered shorter overall survival time than wild-type patients (multivariate COX regression analysis, HR = 2.72, 95% CIs = 1.47-5.09; p-value = 0.012). At stage III, PIK3CA mutated patients were more likely to relapse (multivariate Logistic regression analysis, exon 9: OR = 2.54, 95% CI = 1.34-4.73, p = 0.003; exon 20: OR = 3.89, 95% CI = 1.66-9.10, p = 0.002). The concordance index of the nomogram for predicting the recurrence risk of stage III patients was 0.685. After cetuximab treatment, the median PFS of PIK3CA exon 9 wild-type patients (n = 9) and mutant patients (n = 5) did not reach a significant difference (3.6 months vs. 2.3 months, Log-rank test, p-value = 0.513).ConclusionsWe found that PIK3CA mutation was an adverse predictive marker for the overall survival of stage IV patients and recurrence of stage III patients, respectively. Further more, we suggested that PIK3CA exon 9 mutations are not negative predictors of cetuximab treatment in KRAS, NRAS, and BRAF wild-type mCRC patients.