bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faire la navette : construire un objet-témoin de la mémoire collective de la ville postindustrielle belge de Verviers
Authors: Aubert Baptiste 
Published: October 2021

Comment rendre compte de la mémoire d’une ville postindustrielle par le médium du cinéma ? Dans cet article, je présente un dispositif cinématographique construit autour de la collecte d’objets et de témoignages. En revisitant la notion d’« objet-témoin », je parcours les brocantes de la ville de Verviers afin d’acquérir d’anciennes navettes de métiers à tisser et de reconstruire leur histoire avec les vendeurs·euses qui s’en séparent. L’ensemble des récits collectés me permet de questionner, puis de représenter la « mémoire collective » de cette ville postindustrielle belge.
Entre les visages : l’image-témoin en glissement
Authors: Baronian Marie-Aude 
Published: October 2021

Cet article se concentre sur un des tropes majeurs du témoignage audiovisuel : le visage. Il s’agit de réfléchir, dans le contexte de la violence de masse, à la façon dont le visage cristalliserait l’image-témoin elle-même. Pour ce faire, deux installations vidéo sont prises en compte : Entre l’écoute et la parole : derniers témoins. Auschwitz-Birkenau 1945–2005 (2010) de l’artiste Esther Shalev-Gerz et Chorus (2015) du cinéaste Atom Egoyan. Les deux artistes touchent, respectivement, à la Shoah et au génocide des Arméniens en multipliant les écrans par lesquels les visages des survivants (réels ou fictifs) apparaissent comme les seuls possibles loci du témoignage indicible. Parallèlement, l’article insiste sur la pertinence de la pensée du philosophe Emmanuel Levinas lorsqu’on invoque la relation entre image et témoignage au-delà des régimes représentationnels et spectatoriels. Au bout du compte, on tentera de désacraliser et de décaricaturer le visage comme figure démonstrative et dévoilante (souvent typique du témoignage audiovisuel), afin de révéler l’infini glissement qui singularise l’image-témoin.
Le commentaire de Jean Cayrol pour Nuit et Brouillard d’Alain Resnais : au confluent du témoignage et de l’intermédialité*
Authors: Santerre Ariane 
Published: October 2021

Cet article se consacre à l’apport du poète et résistant déporté Jean Cayrol au documentaire Nuit et brouillard (1956) d’Alain Resnais en croisant les approches littéraire, testimoniale et intermédiale. S’inspirant de ce film classique comme étude de cas, l’enjeu principal de cette contribution consiste à examiner l’interaction entre texte et images de manière à interroger, à travers leur médium respectif ou par le fait de leur combinaison, les possibilités ainsi que les limites de l’expérience communicative de l’extrême.
Faire son temps. Boltanski/Benjamin, le conteur comme témoin
Authors: Klein Anne 
Published: October 2021

Le témoignage considéré comme la transmission de quelque chose du passé est ici appréhendé à travers la démarche de Christian Boltanski. La proposition s’appuie sur une remémoration de Faire son temps, la plus récente des oeuvres-expositions de l’artiste. En croisant une lecture du Conteur de Walter Benjamin et de l’oeuvre de Boltanski, dont on postule qu’elle se compose des installations et de la parole de l’artiste, on cherche à comprendre les ressorts du témoignage comme modalité de transmission de et par l’expérience. Boltanski semble finalement contredire l’affirmation de Benjamin, selon qui l’art de conter était, en 1936, voué à disparaître.
Role of Point of Care Ultra Sound (POCUS) in Assessment of Fluid Resuscitation in Septic Patients
Authors: Fouad Sohier , Elshamaa Nagat , El-Baradey Ghada , Elgendy Hala 
Published: October 2021

Background: Initial fluid resuscitation in sepsis must be guided by clinical judgment based on ongoing reevaluation of the hemodynamic status (heart rate, blood pressure, arterial oxygen saturation, respiratory rate, temperature, urine output) and ultrasound measurements (stroke volume, cardiac output, lung ultrasound and inferior vena cava diameter) as positive fluid balance is harmful.
Methods: Adults Patients (≥ 18 years old) with symptoms or signs of tissue hypoperfusion (Sequential organ failure assessment score SOFA≥ 2) are included. Patients with elevated intra-abdominal pressure (as, ascites, pregnancy), Recent abdominal operation, cannot lie flat, Patient on mechanical ventilation and patients with valvular heart disease were excluded. IVC CI, SV, COP and B mean score were measured on patient arrival and after every 10 ml/kg isotonic saline over the first hour of patient arrival. Thereafter, patients were divided into two groups high caval index and low caval index according to inferior vena cava collapsibility index.
Results: Among our 50 patients,38% of patients were with high caval index and 62% have low caval index.
Conclusion: POCUS has additive value in guiding of fluid resuscitation in sepsis in order to avoid fluid overload and to identify proper timing of vasopressor use.
Effect of Intravenous Acetaminophen and Flurbiprofen on Postoperative Pain after Lumbar Disc Surgery
Authors: Ono Maki , Terao Yoshiaki , Komatsu Yuya , Shimazaki Ayako , Oji Natsuko , Oji Makito 
Published: October 2021

Aims: Lumbar disc surgery is often associated with moderate to severe postoperative pain. Whether non-steroidal anti-inflammatory drugs or acetaminophen provides effective analgesia following lumbar disc surgery remains controversial. This study aimed to determine whether flurbiprofen produces analgesic effects equivalent to those of acetaminophen after lumbar disc surgery.
Study Design: Prospective, randomized, open-label, placebo-controlled trial
Place and Duration of Study: Department of Anesthesia, Nagasaki Rosai Hospital, Sasebo, Japan, between April 2018 and March 2019.
Methodology: We studied 76 patients who underwent elective lumbar disc surgery under general anesthesia. The patients were randomly allocated to one of three groups. Group A (n=25) received 1000 mg of acetaminophen intravenously every 6 h. Group F (n=25) received 50 mg of flurbiprofen intravenously every 6 h. Group C (n=26) received saline intravenously every 6 h as a placebo. Each drug was started before skin closure 18 h after surgery. All patients were anesthetized under total intravenous anesthesia with propofol and remifentanil and received fentanyl before skin closure. Postoperative pain was evaluated using a numerical rating scale (NRS) at 0, 1, 3, 6, 12, 18, and 24 h postoperatively. The patients were administered diclofenac sodium or loxoprofen, as rescue analgesics, as needed.
Results: There were no significant differences in patient characteristics among the three groups. There were no significant differences in NRS scores among the three groups during the study period. However, rescue analgesics were administered significantly less frequently in group F than in groups A and C over 12 h and 24 h, respectively.
Conclusion: The results of this study showed that flurbiprofen might provide more effective analgesia than acetaminophen following lumbar disc surgery.
Flexible Metal‐Organic Framework for Mechanical Sub Tbyte inch−2 Data Recording under Ambient Condition
Authors: Alekseevskiy P. V. , Rzhevskiy S. , Gilemkhanova V. , Kulachenkov N. K. , Sapianik A. , Barsukova M. , Fedin V. P. , Milichko V. A. 
Published: October 2021

AbstractMetal‐organic frameworks (MOFs), demonstrating structural response on external stimuli, represent a promising family of crystalline materials for microelectronic and data storage devices. Herein, manipulation with MOF structure at the nanometer scale for the device miniaturization is still a challenge. Here, mechanical recording and reading the nanometer scale patterns onto flexible 2D MOF at ambient conditions are reported. Treatment of the MOF surface with a hot solvent decreases the roughness up to 1/7 of the layer thickness. Therefore, an atomic force microscope probe is allowed to cause the deformations with the spatial resolution up to 25 nm (≈0.1 Tbyte inch−2 storage density) and the depth from 0.4 nm. Selective chemical etching by the solvent can further develop the pattern, while the integrity of the MOF structure maintains. The realization of the "read‐only‐memory" concept on flexible MOF at ambient conditions paves the way for next‐generation sustainable data storage materials.
Elucidating Extracellular Matrix and Stiffness Control of Primary Human Hepatocyte Phenotype via Cell Microarrays
Authors: Monckton Chase P. , Brougham‐Cook Aidan , Kaylan Kerim B. , Underhill Gregory H. , Khetani Salman R. 
Published: October 2021

AbstractHow the liver's extracellular matrix (ECM) protein composition and stiffness cooperatively regulate primary human hepatocyte (PHH) phenotype is unelucidated. Here, protein microarrays and high‐content imaging with single‐cell resolution are utilized to assess PHH attachment/functions on 10 major liver ECM proteins in single‐ and two‐way combinations robotically spotted onto polyacrylamide gels of 1 or 25 kPa stiffness. Albumin, cytochrome‐P450 3A4 (CYP3A4), and hepatocyte nuclear factor alpha (HNF4α) positively correlate with each other and cell density on both stiffnesses. The 25 kPa stiffness supports higher average albumin and HNF4α expression after 14 d, while ECM protein composition significantly modulates PHH functions across both stiffnesses. Unlike previous rodent data, PHH functions are highest only when collagen‐IV or fibronectin are mixed with specific proteins, whereas noncollagenous proteins without mixed collagens downregulate functions. Combination of collagen‐IV and hyaluronic acid retains high CYP3A4 on 1 kPa, whereas collagens‐IV and ‐V better retain HNF4α on 25 kPa over 14 d. Adapting ECM conditions to 96‐well plates containing conjugated hydrogels reveals novel regulation of other functions (urea, CYP1A2/2A6/2C9) and drug‐mediated CYP induction by the ECM protein composition/stiffness. This high‐throughput pipeline can be adapted to elucidate ECM's role in liver diseases and facilitate optimization of engineered tissues.
Metal nanocluster‐based devices: Challenges and opportunities
Authors: Chen Lizhen , Black Andres , Parak Wolfgang J. , Klinke Christian , Chakraborty Indranath 
Published: October 2021

AbstractAtomically precise nanoclusters (NCs) with fascinating physicochemical characteristics different from their nanoparticles (NPs) counterparts have gained increasing attention in diverse fields of applications. The foremost outcome of such NC‐based applications is leading to transform them into devices. In fact, there are already some reports on the development of NC‐based devices. For instance, NCs exhibit their potential in solar cells, showing high light‐harvesting efficiency comparable to traditional semiconductor solar cells. Further, recent progress in characterizing Au NCs films and micro‐crystals shows semiconductor‐like properties such as field effect and photoresponse. These successes indicate that metal NCs possess a high potential for application in multidisciplinary areas for advancing the development in fundamental and practical purposes. However, no such comprehensive review is available to highlight recent advances and new applicable devices based on noble metal NCs. Herein, we reviewed the recent development in this area, including synthesis challenges of metal NCs and related applications of NC‐sensitized solar cells, strain sensors, chemo‐/biosensors, transistors, floating memory, and other devices. Furthermore, the future opportunities such as modifying synthetic methods to make other metal NCs, enhancing the efficiency of solar cells, and exploring more NC‐based devices alternative to semiconductors are pointed out. We hope that rapidly increasing interest in NC‐based devices will stimulate the research in this area and inspire the advances in combined devices accordingly.
Enhanced electrochemical performance of neural electrodes based on PEDOT:PSS hydrogel
Authors: Zeng Qi , Wu Tianzhun 
Published: October 2021

AbstractPoly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) has attracted much attention on applications of neural interfaces and other biomedical fields due to its excellent electrical performances and good biocompatibility. However, its stability still remains challenge. Here, a conductive polymer hydrogel (CPH) made from PEDOT:PSS is modified on platinum (Pt) substrate successfully through electrochemical gelation, employing copper (Cu) as the sacrificial layer. The as‐prepared CPH electrode provides extensive large surface area with good adhesion after dried in the air. The uniform flower‐like structure helps the electrode achieve a significantly low square impedance down to 10.09 Ω cm2 (reduction of 54.89%) at 1 kHz, compared with that of bare Pt. It exhibits a high cathodic charge storage capacity (CSCc) up to 82.36 mC cm−2, about 27 and 16.18 times higher than that of bare Pt and PEDOT:PSS coating respectively. Besides, no obviously variation of CSCc occurs after 5 CV cycles in phosphate buffered saline (PBS), and superior charge injection capacity (CIC) was also observed. Such CPH material presents great potential for preparing functionalized flexible electrode, implying promising applications on neural implants and other flexible electronics.
Synthesis of a Negative Photochrome with High Switching Quantum Yields and Capable of Singlet‐Oxygen Production and Storage
Authors: Ziani Zakaria , Loiseau Frédérique , Lognon Elise , Boggio‐Pasqua Martial , Philouze Christian , Cobo Saioa , Royal Guy 
Published: October 2021

AbstractA dimethyldihydropyrene (DHP) photochromic unit has been functionalized by donor (triphenylamine group) and acceptor (methylpyridinium) substituents. This compound was characterized by NMR, absorption and emission spectroscopies as well as cyclic voltammetry, and its properties were rationalized by theoretical calculations. The incorporation of both electron‐donor and ‐withdrawing groups at the photochromic center allows i) an efficient photo‐isomerization of the system when illuminated at low energy (quantum yield: Φc‐o=13.3 % at λex=660 nm), ii) the reversible and quantitative formation of two endoperoxyde isomers when illuminated under aerobic conditions at room temperature, and iii) the storage and production of singlet oxygen. The photo‐isomerization mechanism was also investigated by spin‐flip TD‐DFT (SF‐TD‐DFT) calculations.
Family‐based treatment for adolescent anorexia nervosa: Outcomes of a stepped‐care model
Authors: Le Grange Daniel , Pradel Martin , Pogos Danielle , Yeo Michele , Hughes Elizabeth K. , Tompson Alicia , Court Andrew , Crosby Ross D. , Sawyer Susan M. 
Published: October 2021

AbstractObjectiveStepped‐care models of treatment are underexplored in eating disorders. To enhance treatment outcomes, and informed by literature about adaptations to family‐based treatment (FBT), we developed an FBT‐based stepped‐care model for adolescents with anorexia nervosa (AN) that was consistent with family preference (i.e., tailored) and responsive to adolescent needs (i.e., intensity). The aim of this study was to evaluate the effectiveness of this model in terms of remission at end‐of‐treatment.MethodAdolescents (N = 82), aged 12–18 years (M = 15.1, SD = 1.8) and meeting Diagnostic and Statistical Manual of Mental Disorders 5th Edition criteria for AN, were assessed at baseline, Weeks 24 and 48. FBT was tailored to family preference and clinical need, with 16–18 sessions by Week 24. This was followed by three FBT booster sessions or an extension of FBT plus booster sessions (Week 48). The primary outcome was defined as weight > 95% of %median body mass index plus within 1 SD of the Eating Disorder Examination (EDE) global score community norms.ResultsRemission rates were 45.1% and 52.4% at Weeks 24 and 48, respectively. Commensurable improvements were evident across secondary outcomes (e.g., EDE subscale scores). As a reference point, remission rates compared positively with results from a recent randomized clinical trial from the same center and at the same time points (Week 24:45.1% vs. 32.1% and Week 48:52.4% vs. 30.2%). Controlling for propensity score, no statistically significant differences were observed.DiscussionThis stepped‐care model, designed to be responsive to the individual needs of adolescents and their families, achieved encouraging rates of remission. This study provides an important signal that supports future clinical trials of stepped‐care models for adolescents with AN.
Voltammetric Sensing of Soybean Agglutinin Using an Electrode Modified with Electron‐transfer, Carbohydrate‐mimetic/Cross‐linker‐peptide‐collagen Film
Authors: Ishizaki Sora , Kuramitz Hideki , Sugawara Kazuharu 
Published: October 2021

AbstractWe constructed an electrochemical sensor based on an electrode modified with electron‐transfer, carbohydrate‐mimetic peptides on collagen film. The peptide consisted of Ac‐Y4C combined with soybean agglutinin (SBA). To evaluate the binding between SBA and the peptide, we prepared Ac‐Y4CAn (3‐6) containing oligoalanine as a cross‐linker. When SBA and Y4C on the electrode were incubated, the peak was decreased by the SBA uptake of the peptide. The change in the peak current using Ac‐Y4CA6 was the greatest of the four peptides. The calibration curve was linear and ranged from 4.0×10−14 to 1.2×10−12 M with a detection limit of 1.3×10−14 M.
Introduction to the Special Series, “Incorporating Nature-based Solutions into the Built Environment”
Authors: Suedel Burton C. , Oen Amy M. P. 
Published: October 2021

Abstract
Incorporating nature-based solutions (NBSs) into the built environment supports the ongoing sustainability challenge as emphasized in the United Nations' Sustainable Development Goals (SDGs) and has particular relevance for SDG Goal #11 (Sustainable cities and communities), which seeks greater efficiencies in urban planning and management practices that address aging infrastructure and ongoing air, water, and soil pollution. The short communications and research articles in this special series exemplify many of these aspects, highlighting the application of NBSs and showcasing the latest environmental research and policy solutions to support this. Nature-based solutions in the built environment aim to promote the understanding of the transdisciplinary nature of NBSs and enhance the global awareness of the value of NBSs by providing a diversity of solutions to illustrate the positive economic, social, and environmental benefits of NBSs in the built environment. Integr Environ Assess Manag 2022;18:39–41. © 2021 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
KEY POINTS
Nature-based solutions (NBSs) are an umbrella concept that incorporates key concepts of green infrastructure, ecosystem restoration, ecosystem engineering, and ecosystem-based adaptation and is recognized to improve biodiversity and deliver meaningful environmental, social, and economic benefits. NBSs can make an important contribution toward protecting infrastructure from climate change impacts. Transdisciplinary collaboration and participatory approaches to include codesign and coproduction of NBSs have the potential to improve NBS implementation as well as their maintenance.
Time‐gated interferometric detection increases Raman scattering to fluorescence signal ratio in biological samples
Authors: Ksantini Nassim , Veilleux Israel , de Denus‐Baillargeon Marie‐Maude , Orsini Patrick , Dicaire Isabelle , Lecourt Jean‐Bernard , Gognau Alexandre , Hernandez Yves , Baylon Antonio , Massabki Maroun , Lesage Frederic , Leblond Frederic 
Published: October 2021

AbstractAttainable levels of signal‐to‐background ratio (SBR) in Raman spectroscopy of biological samples is limited by the presence of endogenous fluorophores. It is customary to remove the ubiquitous fluorescence background using postacquisition data processing. However, new approaches are needed to reduce background contributions and maximize the fraction of the sensor dynamical range occupied by Raman photons. Time‐resolved detection using pulsed lasers and time‐gated measurements can be used to address the signal‐to‐background problem in biological samples by limiting light detection to nonresonant interaction phenomena with relaxation time scales occurring on sub‐nanosecond time scales, thereby excluding contributions from resonant phenomena such as fluorescence. A time‐gated Fourier‐transform spectrometer was assembled using a commercially available interferometer, a single channel single‐photon avalanche diode and time tagging electronics. A time gate of 300 ps increased the signal‐to‐background‐ratio of the 1440 cm−1 Raman band from 36% to 69% in an olive oil sample hereby demonstrating the potential of this approach for autofluorescence suppression.
Heterocyclic Schiff base derivatives containing pyrazolone moiety: Synthesis, characterization, and in vitro biological studies
Authors: Çınar Ercan , Başaran Eyüp , Erdoğan Ömer , Çakmak Reşit , Boğa Mehmet , Çevik Özge 
Published: October 2021

AbstractIn this study, some pyrazolone‐based Schiff base derivatives 2a‐e (except 2a) were synthesized for the first time and structurally illuminated by some spectroscopic techniques (1H, 13C NMR, FT‐IR) and elemental analysis. All synthesized molecules were screened for their anticancer and antioxidant activities, as well as AChE, BChE, and tyrosinase inhibitory properties. The obtained results exhibited that compounds 1b (IC50 = 9.497 μΜ) and 2a (IC50 = 30.49 μΜ) significantly decreased the proliferation of HeLa cells. On the other hand, the apoptotic effects of these two compounds were investigated with acridine orange/propidium iodide double staining. The apoptotic cell ratios of the molecules treated with these two compounds were determined as 60 and 64%. Compound 2b (IC50 = 17.95 ± 0.47 μΜ) was determined to be a very active substance in the ABTS assay. Compound 2e (A0.5 = 43.75 ± 0.62 μM) indicated the closest antioxidant activity to the standard compound α‐TOC (A0.5 = 50.58 ± 0.39 μM) in the cupric reducing antioxidant capacity (CUPRAC) assay. In inhibition studies of enzymes, it was determined that compound 2c had a very active molecule in AChE, BChE, and tyrosinase inhibitory activities with 82.79 ± 1.03, 91.39 ± 1.06, and 92.60 ± 1.80% inhibition, respectively. It was determined that the target molecules 2a‐e showed better antioxidant and enzyme inhibitory activities than those of ester derivatives 1a‐e.
High expression of DHX9 promotes the growth and metastasis of hepatocellular carcinoma
Authors: Shi Feng , Cao Shengli , Zhu Yaohua , Yu Qiwen , Guo Wenzhi , Zhang Shuijun 
Published: October 2021

AbstractBackgroundDHX9, an NTP‐dependent RNA helicase, is closely associated with the proliferation and metastasis of some tumor cells and the prognosis of patients, but its role in hepatocellular carcinoma (HCC) is not well‐known. This study was performed to explore the expression and role of DHX9 in HCC.MethodsThe expression of DHX9 in HCC tissues and cell lines was detected by TCGA database, qPCR, western blotting, and immunohistochemistry. The relationship between the DHX9 expression level and the prognosis of patients with HCC was accessed. Then, the function of DHX9 knockdown in HCC cells was examined by CCK‐8, scratch, Transwell, and apoptosis assays. Epithelial‐mesenchymal transition (EMT) was detected by western blotting.ResultsDHX9 was highly expressed in HCC tissues by analyzing both TCGA database and clinical samples. High DHX9 expression level was associated with TNM stage, vascular invasion and metastasis of HCC patients, and was an independent adverse prognostic factor. DHX9 knockdown significantly inhibited cell proliferation, migration, invasion and EMT and increased cell apoptosis in HCC cells.ConclusionOur findings suggest that DHX9 participates in the progression of HCC as an oncogene and may be a potential target for the clinical diagnosis and therapy of HCC.