bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting Aberrant Expression of STAT3 and AP-1 Oncogenic Transcription Factors and HPV Oncoproteins in Cervical Cancer by Berberis aquifolium
Authors: Singh Tejveer , Chhokar Arun , Thakur Kulbhushan , Aggarwal Nikita , Pragya Pragya , Yadav Joni , Tripathi Tanya , Jadli Mohit , Bhat Anjali , Gupta Pankaj , Khurana Anil , Chandra Bharti Alok 
Published: October 2021

Background: Present study examines phytochemical preparation that uses berberine’s plant source B. aquifolium root for availability of similar anti-cervical cancer (CaCx) and anti-HPV activities to facilitate repurposing of the B. aquifolium based drug in the treatment of CaCx.Purpose: To evaluate therapeutic potential of different concentrations of ethanolic extract of B. aquifolium root mother tincture (BAMT) against HPV-positive (HPV16: SiHa, HPV18: HeLa) and HPV-negative (C33a) CaCx cell lines at molecular oncogenic level.Materials and Methods: BAMT was screened for anti-proliferative activity by MTT assay. Cell cycle progression was analyzed by flowcytometry. Then, the expression level of STAT3, AP-1, HPV E6 and E7 was detected by immunoblotting, whereas nuclear localization was observed by fluorescence microscopy. Phytochemicals reportedly available in BAMT were examined for their inhibitory action on HPV16 E6 by in silico molecular docking.Results: BAMT induced a dose-dependent decline in CaCx cell viability in all cell types tested. Flowcytometric evaluation of BAMT-treated cells showed a small but specific cell growth arrest in G1-phase. BAMT-treatment resulted in reduced protein expression of key transcription factors, STAT3 with a decline of its active form pSTAT3 (Y705); and components of AP-1 complex, JunB and c-Jun. Immunocytochemistry revealed that BAMT did not prevent the entry of remnant active transcription factor to the nucleus, but loss of overall transcription factor activity resulted in reduced availability of transcription factors in the cancer cells. These changes were accompanied by gradual loss of HPV E6 and E7 protein in BAMT-treated HPV-positive cells. Molecular docking of reported active phytochemicals in B. aquifolium root was performed, which indicated a potential interference of HPV16 E6’s interaction with pivotal cellular targets p53, E6AP or both by constituent phytochemicals. Among these, berberine, palmatine and magnoflorine showed highest E6 inhibitory potential.Conclusion: Overall, BAMT showed multi-pronged therapeutic potential against HPV infection and cervical cancer and the study described the underlying molecular mechanism of its action.
Safety Profile of Ibrutinib: An Analysis of the WHO Pharmacovigilance Database
Authors: Allouchery Marion , Tomowiak Cécile , Lombard Thomas , Pérault-Pochat Marie-Christine , Salvo Francesco 
Published: October 2021

As ibrutinib has become a standard of care in B-cell malignancies in monotherapy or in combination with other agents, definition of its safety profile appears essential. The aim of this study was to further characterize the safety profile of ibrutinib through the identification of potential safety signals in a large-scale pharmacovigilance database. All serious individual case safety reports (ICSRs) in patients aged ≥18 years involving ibrutinib suspected in the occurrence of serious adverse drug reactions or drug interacting from November 13th, 2013 to December 31st, 2020 were extracted from VigiBase, the World Health Organization global safety database. Disproportionality reporting was assessed using the information component (IC) and the proportional reporting ratio (PRR), with all other anticancer drugs used as the reference group. To mitigate the confounding of age, two subgroups were considered: patients aged&lt;75 years and ≥75 years. A signal of disproportionate reporting (SDR) was defined if both IC and PRR were significant. A total of 16,196 ICSRs were included. The median age of patients was 72.9 years, 42.6% of ICSRs concerned patients aged ≥75 years, and 64.2% male patients. More than half (56.2%) of ICSRs resulted in hospitalization or prolonged hospitalization. Among 713 SDRs, 36 potential safety signals emerged in ibrutinib-treated patients, mainly ischemic heart diseases, pericarditis, uveitis, retinal disorders and fractures. All potential safety signals having arisen in this analysis may support patient care and monitoring of ongoing clinical trials. However, owing to the mandatory limitations of this study, our results need further confirmation using population-based studies.
The Influence of Gratitude on the Meaning of Life: The Mediating Effect of Family Function and Peer Relationship
Authors: Zhang Ping , Ye Lin , Fu Fang , Zhang Lan Ge 
Published: October 2021

Objective: This study aimed to explore the influence of gratitude on the meaning of life of college students and the mediating effect of family function and peer relationships.Methods: A total of 1,049 college students (mean age: 18.59 ± 0.96 years) were investigated by gratitude scale, family function scale, peer relationship questionnaire, and meaning of life scale.Results: (1) Gratitude was positively correlated with meaning existence (r = 0.39, P &lt; 0.05), meaning seeking (r = 0.23, P &lt; 0.05), and peer relationship (r = 0.32, P &lt; 0.05); meanwhile, it is also positively correlated with family function (r = 0.34, P &lt; 0.05); (2) family function partially mediates the relationship between gratitude and meaning of life. Similarly, peer relationship partially mediates the relationship between gratitude and meaning of life.Conclusion: The mediating model showed that grateful individuals can better sense the meaning of life by perceiving good family function and good peer relationships.
A Counseling Application as an Alternative Tool in Increasing Coping Self-Efficacy Among University Students With Academic Distress During Coronavirus Disease 2019 Pandemic in Indonesia: A Study Protocol for a Randomized Controlled Non-Inferiority Trial
Authors: Hinduan Zahrotur Rusyda , Wedyaswari Miryam , Reswara Ilham Phalosa , Setyowibowo Hari 
Published: October 2021

The coronavirus disease 2019 (COVID-19) pandemic increased education-related distress among University students globally, including in Indonesia. Psychological factors, such as academic demands, limited opportunity to meet their peers, problematic use of technology, and domestic problems, influenced the well-being of the students, leading to poor academic performance. A mobile-based counseling application was developed to address the distress among University students. The application was meant to reach students living remotely to enable them to access psychological assistance. Therefore, the purpose of this study was to describe a protocol aimed to evaluate the equivalence of the application when compared to the Treatment-As-Usual (TAU) in increasing the coping self-efficacy (CSE) and resilience of students as well as in decreasing their level of depression. A two-armed parallel randomized control non-inferiority trial will be conducted among approximately 430 students with selected academic problems. The participants will be randomly allocated into the TAU and the intervention groups. The primary and secondary outcomes will be measured by the Indonesian versions of the Coping Self-Efficacy (CSE) Scale, the Resilience Scale (RS-14), and the Patient Health Questionnaire (PHQ-9). The data will be collected at baseline, at the end of each session, and after 3 months. The outcomes will be analyzed using repeated-measures ANOVAs, intention-to-treat, and per-protocol analysis. If proven, the application will be used as an alternative media in helping the students.Clinical Trial Registration: Thailand Clinical Trials Registry (TCTR20200530001); Date of registration: May 28, 2020.
Meaning Reflectivity in Later Life: The Relationship Between Reflecting on Meaning in Life, Presence and Search for Meaning, and Depressive Symptoms in Older Adults Over the Age of 75
Authors: Dewitte Laura , Dezutter Jessie 
Published: October 2021

Background: Over the last decades, there is growing attention for the importance of meaning in life for older adults. However, there is virtually no insight into the mental processes that contribute to this experience. Some scholars recently called for an investigation of meaning reflectivity, or the process of reflecting on issues specifically related to meaning in life. In this study, we explored to what extent older adults talk and think about issues of meaning in life, and how this meaning reflectivity is related to the search for and presence of meaning in life, and to depressive symptoms.Method: In this cross-sectional observational study, 282 community-residing older adults (75 or older) in Belgium filled in paper questionnaires on meaning in life (presence and search), depressive symptoms, and meaning reflectivity (categorical item). ANOVA analyses were used to explore differences in meaning in life and depressive symptoms across the meaning reflectivity categories. Regression and negative binomial models investigated the association between meaning reflectivity and presence, search and depressive symptoms. Finally, an exploratory structural equation model examined whether presence of meaning statistically mediated the relationship between meaning reflectivity and depressive symptoms.Results: The majority of participants (42.4%) indicated that they had thought about meaning in life before, 23.2% indicated that they had talked about it before, 18% indicated that they hadn’t thought about it before but found it interesting, and 16.4% indicated that they were indifferent/unconcerned about meaning in life. The latter group reported lower levels of presence of meaning and search for meaning and higher levels of depressive symptoms. Belonging to this category was also associated with lower presence and search in regression analyses, but not with depressive symptoms above the effect of presence of meaning. Exploratory mediation analyses suggested that presence of meaning may be a mediator between meaning reflectivity and depressive symptoms.Conclusion: Meaning reflectivity is an important process to consider in the context of the experience of meaning in life for older adults. Those older adults who are indifferent about issues of meaning in life might be more vulnerable to experience a lack of meaning and depressive symptoms.
Mindfulness Training Associated With Resting-State Electroencephalograms Dynamics in Novice Practitioners via Mindful Breathing and Body-Scan
Authors: Ng Hei-Yin Hydra , Wu Changwei W. , Huang Feng-Ying , Cheng Yu-Ting , Guu Shiao-Fei , Huang Chih-Mao , Hsu Chia-Fen , Chao Yi-Ping , Jung Tzyy-Ping , Chuang Chun-Hsiang 
Published: October 2021

Objectives: Mindfulness-based stress reduction has been proven to improve mental health and quality of life. This study examined how mindfulness training and various types of mindfulness practices altered brain activity.Methods: Specifically, the spectral powers of scalp electroencephalography of the mindfulness-based stress reduction (MBSR) group (n=17) who underwent an 8-week MBSR training—including mindful breathing and body-scan—were evaluated and compared with those of the waitlist controls (n=14).Results: Empirical results indicated that the post-intervention effect of MBSR significantly elevated the resting-state beta powers and reduced resting-state delta powers in both practices; such changes were not observed in the waitlist control. Compared with mindful breathing, body-scanning resulted in an overall decline in electroencephalograms (EEG) spectral powers at both delta and low-gamma bands among trained participants.Conclusion: Together with our preliminary data of expert mediators, the aforementioned spectral changes were salient after intervention, but mitigated along with expertise. Additionally, after receiving training, the MBSR group’s mindfulness and emotion regulation levels improved significantly, which were correlated with the EEG spectral changes in the theta, alpha, and low-beta bands. The results supported that MBSR might function as a unique internal processing tool that involves increased vigilant capability and induces alterations similar to other cognitive training.
The Positive Effect of Perceived Exercise Benefit and the Negative Effect of Perceived Severity of Disease and Weakness on College Students' Amount of Exercise: The Mediate and Suppressor Role of Physical Fitness Evaluation Self-Efficacy
Authors: Xue-liu Li , Mu Xia 
Published: October 2021

Background: The decline in the physical fitness of college students has become a serious social problem worldwide. Therefore, exploring the factors affecting the amount of exercise of college students is of great significance in improving college students' physique. According to the expectation value theory and previous studies, perceived exercise benefit and perceived severity of disease and weakness may have positive or negative impact on exercise behavior, and according to the self-efficacy theory, physical evaluation self-efficacy may be the most powerful motivational factors and it play a mediating role between other factors and exercise behavior. Therefore, this study was designed to determine the critical role of physical evaluation self-efficacy in the path of perceived exercise benefit and perceived severity of disease and weakness affecting the amount of exercise of college students.Methods: By means of Physical Fitness Health Belief of College Students Scale and Physical Activity Rating Scale (PARS-3), 801 undergraduate students were investigated in this study.Results: (1) When perceived exercise benefit, exercise self-efficacy, and severity of perceived disease and weakness predicted the amount of exercise separately, the first two have a positive effect on the amount of exercise, but the latter has no effect. However, when these three factors entered the regression equation at the same time, the perceived severity of disease and weakness had a negative effect on the amount of exercise. (2) The influence of physical evaluation self-efficacy on the college students' the amount of exercise was bigger than benefit of perceived exercise and the perceived severity of disease and weakness in both separated and simultaneous comparison conditions. (3) Physical evaluation self-efficacy completely mediated the positive effect of perceived exercise benefits on the amount of exercise and inhibited the negative effect of perceived severity of disease and weakness on the amount of exercise.Conclusion: Physical evaluation self-efficacy has a strong predictive power on the amount of exercise of college students. This was reflected in its ability to mediate the impact of expectation of exercise results and in its ability to suppress the adverse effects of concern about illness on exercise.
Estimating the Number of Civilian Casualties in Modern Armed Conflicts–A Systematic Review
Authors: Khorram-Manesh Amir , Burkle Frederick M. , Goniewicz Krzysztof , Robinson Yohan 
Published: October 2021

Objective:To examine the possibility of estimating the number of civilian casualties in modern armed conflicts.Methods:A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using PubMed, Scopus, and Web of Science search engines. The outcome was analyzed using a qualitative inductive thematic analysis. The scientific evidence of selected article was assessed, using the Health Evidence Quality Assessment Tool.Findings:The review of 66 included articles in this study indicates that with an increasing number of public health emergencies and the lack of vital elements of life such as water and food, emerging armed conflicts seem to be inevitable. In contrast to military-led cross-border traditional wars, modern armed conflicts affect internally on local communities and take civilian lives. Consequently, the measures and tools used in traditional military-led cross-border wars to adequately tally wounded and dead for many decades under the mandates of the International Humanitarian Law, is insufficient for modern warfare. While casualty counting during modern conflicts is deficient due to organizational, political or strategic reasons, the international organizations responsible for collecting such data (the International Federation of Red Cross and Red Crescent and International Institute of Humanitarian Law) face difficulties to access the conflict scene, resulting in under-reported, unreliable or no-reported data.Conclusion:There are challenges in estimating and counting the number of civilian casualties in modern warfare. Although the global need for such data is evident, the risks and barriers to obtaining such data should be recognized, and the need for new international involvement in future armed conflicts should be emphasized.
A Mixed-Methods Feasibility Study of Integrated Pediatric Complex Care: Experiences of Parents With Care and the Value of Parent Engagement in Research
Authors: Hlyva Oksana , Rae Charlene , Deibert Shelby , Kamran Rakhshan , Shaikh Haniah , Thabane Lehana , Rosenbaum Peter , Klassen Anne , Lim Audrey 
Published: October 2021

Introduction:Children with medical complexity (CMC) are among the most vulnerable children in society. These children and their families face challenges of fragmented care and are at risk for poorer health outcomes. Families with CMC play a vital role in providing care and navigating the complexities of healthcare systems. It is essential to understand the best ways to engage these families in research to improve the care and optimize the health of CMC.Objectives:This study explored parent engagement within the context of a feasibility study evaluating an Integrated Tertiary Complex Care (ITCC) clinic created to support CMC closer to home. This paper aimed: (1) to understand the family experiences of care and (2) to explore parent engagement in the study.Method:This mixed-methods feasibility study included three components. First, feedback from focus groups was used to identify the common themes that informed interviews with parents. Second, one-on-one interviews were conducted with parents to explore their experience with care, such as the ITCC clinic, using an interpretative description approach. Third, the questionnaires were completed by parents at baseline and 6-months post-baseline. These questionnaires included demographic and cost information and three validated scales designed to measure the caregiver strain, family-centered care, and parental health. The recruitment rate, percentage completion of the questionnaires, and open-ended comments were used to assess parent engagement in the study.Results:The focus groups involved 24 parents, of which 19 (14 women, five men) provided comments. The findings identified the importance of Complex Care Team (CC Team) accessibility, local access, and family-centered approach to care. The challenges noted were access to homecare nursing, fatigue, and lack of respite affecting caregiver well-being. In this study, 17 parents participated in one-on-one interviews. The identified themes relevant to care experience were proximity, continuity, and coordination of care. The parents who received care through the ITCC clinic appreciated receiving care closer to home. The baseline questionnaires were completed by 44 of 77 (57%) eligible parents. Only 24 (31%) completed the 6-month questionnaire. The challenges with study recruitment and follow-up were identified.Conclusion:Family engagement was a challenging yet necessary endeavor to understand how to tailor the healthcare to meet the complex needs of families caring for CMC.
Atypical Mineralization Involving Pd-Pt, Au-Ag, REE, Y, Zr, Th, U, and Cl-F in the Oktyabrsky Deposit, Norilsk Complex, Russia
Authors: Barkov Andrei Y. , Nikulin Ivan I. , Nikiforov Andrey A. , Lobastov Boris M. , Silyanov Sergey A. , Martin Robert F. 
Published: October 2021

Highly atypical mineralization involving Pd-Pt, Au-Ag, REE, Y, Zr, U, Th, and Cl-F-enriched minerals is found in zones with base metal sulfides (BMS; ~5 vol.% to 20 vol.%) in the eastern portion of the Oktyabrsky deposit in the Norilsk complex (Russia). The overall variations in Mg# index, 100 Mg/(Mg + Fe2+ + Mn), in host-rock minerals are 79.8 → 74.1 in olivine, 77.7 → 65.3 in orthopyroxene, 79.9 → 9.2 in clinopyroxene, and An79.0 → An3.7. The span of clinopyroxene and plagioclase compositions reflects their protracted crystallization from early magmatic to late interstitial associations. The magnesian chromite (Mg# 43.9) trends towards Cr-bearing magnetite with progressive buildups in oxygen fugacity; ilmenite varies from early Mg-rich to late Mn-rich variants. The main BMS are chalcopyrite, pyrrhotite, troilite, and Co-bearing pentlandite, with less abundant cubanite (or isocubanite), rare bornite, Co-bearing pyrite, Cd-bearing sphalerite (or wurtzite), altaite, members of the galena-clausthalite series and nickeline. A full series of Au-Ag alloy compositions is found with minor hessite, acanthite and argentopentlandite. The uncommon assemblage includes monazite-(Ce), thorite-coffinite, thorianite, uraninite, zirconolite, baddeleyite, zircon, bastnäsite-(La), and an unnamed metamict Y-dominant zirconolite-related mineral. About 20 species of PGM (platinum group minerals) were analyzed, including Pd-Pt tellurides, bismuthotellurides, bismuthides and stannides, Pd antimonides and plumbides, a Pd-Ag telluride, a Pt arsenide, a Pd-Ni arsenide, and unnamed Pd stannide-arsenide, Pd germanide-arsenide and Pt-Cu arseno-oxysulfide. The atypical assemblages are associated with Cl-rich annite with up to 7.54 wt.% Cl, Cl-rich hastingsite with up 4.06 wt.% Cl, ferro-hornblende (2.53 wt.% Cl), chlorapatite (>6 wt.% Cl) and extensive solid solutions of chlorapatite, fluorapatite and hydroxylapatite, Cl-bearing members of the chlorite group (chamosite; up to 0.96 wt.% Cl), and a Cl-bearing serpentine (up to 0.79 wt.% Cl). A decoupling of Cl and F in the geochemically evolved system is evident. The complex assemblages formed late from Cl-enriched fluids under subsolidus conditions of crystallization following extensive magmatic differentiation in the ore-bearing sequences.
Decoupling the sequence of dielectric breakdown in single device bilayer stacks by radiation-controlled, spatially localized creation of oxide defects
Authors: Aguirre Fernando Leonel , Ranjan Alok , Raghavan Nagarajan , Padovani Andrea , Pazos Sebastián Matías , Vega Nahuel , Müller Nahuel , Debray Mario , Molina-Reyes Joel , Pey Kin Leong , Palumbo Félix 
Published: October 2021

Abstract
The breakdown (BD) sequence in high-K/interfacial layer (HK/IL) stacks for time-dependent dielectric breakdown (TDDB) has remained controversial for sub-45 nm CMOS nodes, as many attempts to decode it were not based on proper experimental methods. Know-how of this sequence is critical to the future design for reliability of FinFETs and nanosheet transistors. We present here the use of radiation fluence as a tool to precisely tune the defect density in the dielectric layer, which jointly with the statistical study of the soft, progressive and hard BD, allow us to infer the BD sequence using a single HfO2–SiO
x
bilayered MOS structure.