bluuebunny/crossref_metadata_2025_split huggingface dataset:
The response of human induced pluripotent stem cells to cyclic temperature changes explored by BIO-AFM
Authors: Nie Yan , Wang Weiwei , Xu Xun , Ma Nan , Lendlein Andreas 
Published: August 2021

AbstractHuman induced pluripotent stem cells (hiPSCs) are highly sensitive to extrinsic physical and biochemical signals from their extracellular microenvironments. In this study, we analyzed the effect of cyclic temperature changes on hiPSCs behaviors, especially by means of scanning force microscopy (BIO-AFM). The alternation in cellular mechanics, as well as the secretion and pattern of deposition of extracellular matrix (ECM) protein in hiPSCs were evaluated. The arrangement of the actin cytoskeleton changed with the variation of the temperature. The rearranged cytoskeleton architecture led to the subsequent changes in cell mechanics (Young's modulus of hiPSCs). With the exposure to the cyclic cold stimuli, an increase in the average surface roughness (Ra) and roughness mean square (RMS) was detected. This observation might be at least in part due to the upregulated secretion of Laminin α5 during repeated temporary cooling. The expression of pluripotent markers, NANOG and SOX2, was not impaired in hiPSCs, when exposed to the cyclic cold stimuli for 24 h. Our findings provide an insight into the effect of temperature on the hiPSC behaviors, which may contribute to a better understanding of the application of locally controlled therapeutic hypothermia.Graphic abstractThe cyclic temperature changes, from 37 to 10 °C, rapidly increased the mechanical strength of human-induced pluripotent stem cells (hiPSCs), which could be explained by the re-arrangement of cytoskeletons. The capacity of hiPSCs to remodel the extracellular matrix was also altered by the repeated temporary cooling, as they exhibit an enhanced ability to physically remodulate and secrete the ECM components.
Fire resistance of bi-directionally prestressed concrete under extreme fire loading
Authors: Choi Ji-Hun , Yang Dal-Hun , Choi Seung-Jai , Yi Seong-Tae , Kim Jang-Ho Jay 
Published: August 2021

Infrastructures such as prestressed concrete containment vessels (PCCVs) and liquid gas storage tanks are constructed as bi-directional prestressed concrete (PSC) structures to ensure outstanding leak-tight storage and shielding performance. However, PSC structures exhibit severe vulnerability to high-temperature fire due to the high-strength concrete used and the application of prestressing (PS) stresses to increase the strength of the structures. The PCCV of a 1400 MW advanced power reactor was selected as the target for study. A scaled-down model of the PCCV outer wall was fabricated and tested to determine its resistance to a standard fire-loading scenario. Furthermore, different PS forces were applied to the specimens to evaluate the effect of concrete confinement on the fire resistance. Test data of temperature distribution, PS force loss and residual strength capacity were obtained. The experimental data were used for calibration of a commercial finite-element simulation program (Midas FEA) for structural fire analysis of real-scale concrete structure and infrastructure. The simulation and test results showed significant similarity and the result trends were accurate.
Risk-targeted seismic design of reinforced concrete moment-resisting-frame buildings
Authors: Khademi Morteza , Mansoori Mohammadreza , Hosseini Mirhamid 
Published: August 2021

The seismic design of new structures in Iran is currently based on earthquake hazard maps for a fixed return period of 475 years. However, this can lead to an unequal level of risk due to uncertainty in collapse capacity and differences in hazard curves in different locations. In the work reported in this paper, a risk-targeted approach was used to determine the peak ground acceleration (PGA) for designing reinforced concrete moment-resisting-frame (RC MRF) buildings in four important port cities in southern Iran. The three main parameters considered for determining risk-targeted PGA were the structural fragility curve, the seismic hazard curve and the target annual collapse probability. Nine RC MRF buildings with different geometrical characteristics were evaluated and their fragility curves were extracted. Then, using a risk integral, the annual collapse probability and PGA of the frames were obtained for the studied cities. Comparison of the results showed that an approach proposed in the literature for Europe is in accordance with the results of the approach proposed in this paper.
APPROACH DIFFERENCES OF ORTHOPEDICS AND EMERGENCY MEDICINE PHYSICIANS IN CURRENT TREATMENT PRACTICES OF ACUTE TRAUMATIC FIRST TIME ANTERIOR SHOULDER DISLOCATION
Authors: ÖZMANEVRA Ramadan , DEMİRKIRAN Nihat Demirhan , ÇAPKIN Sercan , OZKULA Ugur , IŞIN Yağmur , KILIÇ Ali İhsan 
Published: August 2021

Objective
Numerous techniques for the reduction of anterior
glenohumeral joint dislocations have been described.
However, there is no consensus on the best technique
for reducing a dislocated glenohumeral joint. This
study aimed to evaluate the approach of emergency
specialists and orthopedic surgeons in the treatment
of acute traumatic first-time anterior shoulder
dislocation.
Material and Methods
Data used in this cross-sectional study were obtained
through a web-based survey from the Turkish
Orthopedics and Traumatology Association mail group
and Emergency Medicine Physicians Association
of Turkey mail group. All orthopedic surgeons
and emergency medicine physicians who were
registered in the database received an information
mail regarding the aim of the questionnaire and a link
to the online survey form (Google Forms, Alphabet
Inc., Mountain View, CA). The survey consisted of 13
questions, which are shown with their corresponding
answer options. The current practices regarding the
management of acute traumatic first-time anterior
shoulder dislocation among orthopedic surgeons
and emergency medicine physicians in Turkey were
evaluated.
Results
A total of 152 orthopedic surgeons and 151 emergency
physicians participated in this survey. The most
common maneuvers used by emergency physicians
to reduce shoulder dislocations were the Hippocrates
technique (19.2%) and Cunningham technique
(19.2%), while orthopedic surgeons preferred the
Hippocrates technique (23.7%) and Kocher technique
(29.6%). It was found that orthopedic surgeons
preferred Kocher and Milch maneuvers more for
shoulder joint dislocation reduction compared to
emergency physicians (p < 0.001 and p = 0.005,
respectively). Both the pre- reduction and postreduction
procedures showed variability between
orthopedic surgeons and emergency physicians.
Conclusion
It would be more appropriate for the emergency
physician and orthopedic surgeons to treat a
patient with shoulder dislocation together as a team
and beneficial to establish a national guideline for
consensus.
Typographical revision and language option in the Evangelium from
Snagov, 1697
Authors: Chirilă Adina , Vieru Roxana 
Published: August 2021

The new edition of the Evangelium printed in Snagov, in 1697 (E 1697) is distinguished from the previous ones by two aspects: a) structure of the text – because the accuracy of the biblical references in relation to the moments of the church year is restored and ensured, thus making the correlation between the liturgical book of ecclesiastical use and the archetype-text, the New Testament, divided into chapters; b) linguistic option of the editor, which specifically and consistently aims at the regime of verbal tenses, i.e., the change of the forms of the simple perfect of the basic edition (E 1693) into forms of compound perfect.
Typographical and linguistic differences identified between E 1697 B[ucharest], E 1697 I[ași] and E 1697 V[ienna], of the eleven copies of the book, preserved to this day, indicate the unfolding of some stages in the realization of the edition, a complex and nonlinear editorial and typographical behaviour.
Digital Humanities in European Research Libraries
Authors: Wilms Lotte 
Published: August 2021

Libraries are increasingly becoming involved in digital humanities research beyond the offering of digital collections. This article examines how libraries in Europe deal with this shift in activities and how they compare with libraries in other parts of the world. This article builds on the results of surveys conducted in Australia, New Zealand, Hong Kong, the United States and the United Kingdom, and compares them with a survey conducted in Europe. We found that European libraries are mostly active in research supporting activities, such as digitisation and storage, while US libraries often include analysis in their activities. Funding comes from the library’s main budget and non-structural funding in a variety of forms. Staff working in DH roles has a diverse range of titles, with various forms of librarians being the most used. Analytical staff such as GIS specialists are only found in the US survey. All surveyed libraries agree that the biggest skill gap amongst their staff is in technical skills. When looking towards the future, European libraries see the role of digital humanities (or digital scholarship) within the library grow and are making plans to facilitate this change within their organisation by positioning themselves as an attractive research partner, by opening and increasing their digital collections and by improving the internal workings of the library.
Diagnostic Patterns of Suspected Covid-19 Patients Using Scor Covid-19, PCR Test and Serological Test in Dr. Soetomo Hospital Surabaya, Indonesia
Authors: Hadi Usman , Bramantono Bramantono , Vitanata M , Rusli Musofa , Rahman Brian Eka , Asmarawati Tripudi , Marfiani Erika , Triyono Erwin Astha 
Published: August 2021

Objective: To find out the diagnostic pattern of COVID-19 using RT-PCR or a rapid antibody test in the suspected group patients.Method: The study was conducted in Dr. Soetomo General Hospital (referal hospital for covid-19, 1500 beds). The study used data on patients with suspected covid-19 who were hospitalized at the Dr. Soetomo General Hospital in Surabaya.Result: There were 200 suspected COVID-19 patients enrolled in this study, the main complaints of cough, fever, dyspnoea, around 69.5%, 75%, and 76.5%, respectively. Although not a common symptom, it seems that anosmia (14%) is typical for COVID-19. Based on this scoring system, a total of 196 patients had a high risk of being infected with COVID-19, and 125 (64%) of them finally showed a positive PCR test. PCR test mostly positive (62.5%), while serological test (rapid imunoglobulin test) mostly non reactive, but there were nonsignificant different between PCR and Serological test (p=0.16 OR: 1.5(0.84-71). Furthermore, if we compare the various existing variables, namely the covid-19 score, immunoglobulin rapid test, and radiological examination, only the radiological examination results can be used as a strong predictor of positive PCR results (p=0.005, OR: 1.68 (0.17-16.43).In this study, we found that abnormal chest radiographs are a good parameter for diagnosing COVID-19, (OR: 2.92; 95% CI, 1.34 -6.34).Conclussion: The initial radiological examination combined with the clinical symptoms of Covid-19 is the most important thing to predict the presence of this disease.
The Association between Serum Lactate Dehydrogenase Level and In-hospital Death due to Pulmonary Embolism
Authors: Ghaffari Samad , Hajizadeh Reza , Mohammadi Tooba , Kavandi Hadis , Mohammadi Kamran , Mohebalizadeh Mehdi , Sedokani Amin 
Published: August 2021

Abstract
Background: Few studies are evaluating the prognostic value of lactate dehydrogenase (LDH) in patients with pulmonary embolism (PE). We analyzed the possible power of serum LDH levels to predict in-hospital mortality.Methods: In this cross-sectional study 217 patients with confirmed PE diagnosis with CT angiography and available serum LDH level at first 24-hours upon admission were included.Results: The mean age of patients was 63.04±16.81 years old, 23 patients (10.6%) died during hospitalization. Multivariate analysis showed that only LDH, WBC were independent predictors of in-hospital mortality, however, this association was not significant.Conclusion: LDH can be a good prognostic marker for predicting in-hospital death in patients with pulmonary embolism.
Quality of Life After Sialendoscopy: Prospective Non-Randomized Study
Authors: de Melo Giulianno Molina , Neves Murilo Catafesta das , Rosano Marcello , Vanni Christiana Maria Ribeiro Salles , Abrahao Marcio , Cervantes Onivaldo 
Published: August 2021

Abstract
Background: The symptomatic (swelling and pain) salivary gland obstructions are caused by sialolithiasis and salivary duct stenosis, negatively affecting quality of life (QOL), with almost all candidates for clinical measures and minimally invasive sialendoscopy. The impact of sialendoscopy treatment on the QOL has been little addressed nowadays. The objective is to prospectively evaluate the impact of sialendoscopy on the quality of life of patients undergoing sialendoscopy due to benign salivary obstructive diseases, measured through QOL questionnaires of xerostomia degree, the oral health impact profile and post sialendoscopy satisfaction questionnaires. Result: 37 sialendoscopies were included, most young female: 64.5% sialolithiasis, 35.4% post-radioiodine; 4.5 times/week painful swelling; 23.5 months symptom duration; pre- and post-sialendoscopy VAS values: 7.42 to 1.29 (p<0.001); 86.5% and 89.2% were subjected to sialendoscopy alone and endoscopic dilatation respectively; 80.6% reported improved symptoms after sialendoscopy in the sialolithiasis clinic (p<0.001). The physical pain and psychological discomfort domain scores were mostly impacted where sialendoscopy provided relief and improvement (p<0.001). We found a positive correlation between sialendoscopy and obstructive stone disease (p<0.001) and no correlation in sialendoscopy satisfaction in xerostomia patients (p=0.009).Conclusions: We found improved symptoms with overall good satisfaction after sialendoscopy correlated with stones; and a negative correlation between xerostomia. Our findings support the evident indication of sialendoscopy for obstructive sialolithiasis with a positive impact on QOL and relative indication to xerostomia that barely improved QOL satisfaction.Trial Registration: WHO Universal Trial Number (UTN): U1111-1247-7028 Brazilian Clinical Trials Registry (ReBeC): RBR-6p8zfs
Performance Evaluation of Geological Disaster Relief Operations in China using SBM-DEA Methodology
Authors: bai pengfei , La ruifang , Duan Qianqian 
Published: August 2021

Abstract
Geological disasters have caused enormous damage to human beings and the economy in China. Chinese government pay great effort on geological disaster relief. Usually, the efficiency of the disaster rescue is the first priority to be considered. Takeing the historical analysis of China's geological disaster rescue as the main line ,in this paper, we developed a slacks-based measure data envelopment analysis (SBM-DEA) model to evaluate the performance of 18 geological disasters relief during 2015–2019 in China, which are used to examine the performance of the geological disasters rescue activities. The results show that though the capabilities of geo-disaster relief is continuous improvement from 2015 to 2019, China’s geological disasters rescue system is still at the primary stage. Especially, the efficiency of landslide rescue operation is pretty low. We analysis the factors influencing the efficiency and provide several suggestions for capacity improvement of geo-disasters rescue.
Does the Presence of Renal Vascular Variation in the Renal Allograft Determine the Outcome of Renal Transplantation? Experience from the National Kidney Transplantation Center, Ethiopia
Authors: Wondmagegn Habtamu , Gebremickael Abinet , Bekele Mahteme , George Mala , Fikadu Teshale , Hailu Tadiwos , Ayele Tsegazeab 
Published: August 2021

Abstract
Background: Renal transplantation is the treatment of choice for people who suffer from end stage renal disease. Renal vascular anatomy is known for presenting a wide range of variations. Kidneys with variant renal vascular anatomy when used as a graft appear to be a potential risk factor that could impair the outcome of kidney transplantation. Information on renal vascular variations and its implication in the surgical outcome of renal transplantation has not been well studied. Hence, the present study was aimed to evaluate the outcomes of transplantation of renal allografts with variant renal vasculature as compared to allografts without renal vascular variation in the national kidney transplantation center of Ethiopia.Methods: A health institution based cross-sectional study was conducted. A retrospective review of the medical records of kidney recipients was performed. A total of 120 renal transplant recipient’s medical records were evaluated. Chi-square test and Independent t test was used to compare the surgical outcomes of renal transplantation. Graft survival was expressed using Kaplan-Meier curves, and was compared using the log-rank test. P values less than 0.05 was considered as statistically significant. Result: Evaluation of the renal transplant outcomes did not have shown a significant difference in the postoperative complication rate, rate of delayed graft function (DGF), creatinine clearance levels at 1 , 6, or 12 months postoperatively, and 1-year graft survival among recipients of allografts with and without renal vascular variations. However, operation time and the length of hospital stay were significantly longer among recipients of allografts with variant vasculature.Conclusion: No significant difference was noted in the outcomes of transplantation of renal allografts with and without vascular variations. Hence, renal allografts with vascular variations are safe to be recruited for transplantation as to this study.
Joint Reconstruction Framework of Compressed Sensing and Nonlinear Parallel Imaging for Dynamic Cardiac Magnetic Resonance Imaging
Authors: Hu Zhanqi , Zhao Cailei , Zhao Xia , Kong Lingyu , Yang Jun , Wang Xiaoyan , Liao Jianxiang , Zhou Yihang 
Published: August 2021

Abstract
Compressed Sensing (CS) and parallel imaging are two promising techniques that accelerate the MRI acquisition process. Combining these two techniques is of great interest due to the complementary information used in each. In this study, we propose a new reconstruction framework for dynamic cardiac imaging that takes advantage of both CS-based dynamic imaging and one nonlinear parallel imaging technique. The method decouples the reconstruction process into two sequential steps: use CS to reconstruct a series of aliased dynamic images from the highly undersampled k-space data; use nonlinear GRAPPA method, one nonlinear technique of parallel imaging, to reconstruct the original dynamic images from the k-space data that has been reconstructed by CS. The sampling scheme of the proposed method is designed to simultaneously satisfy the incoherent undersampling requirement for CS and the structured undersampling requirement for nonlinear parallel imaging. Four in vivo experiments of dynamic cardiac cine MRI were carried out with retrospective undersampling to evaluate the performance of the proposed method. Experiments show the proposed method of dynamic cardiac cine MRI is superior at reducing aliasing artifacts and preserving the spatial details and temporal variations, when compared with k-t FOCUSS and k-t FOCUSS with sensitivity encoding, using the same numbers of measurements. The proposed joint reconstruction framework effectively combines the CS method and one nonlinear technique of parallel imaging, and improves the image quality of dynamic cardiac cine MRI reconstruction when comparing to the state-of-the-art methods.
Functional Connectivity Density Alterations in Children with Strabismus and Amblyopia based on Resting-state Functional Magnetic Resonance Imaging (fMRI)
Authors: Shi Yi-Dan , Ge Qian-Min , Lin Qi , Liang Rong-Bin , Li Qiu-Yu , Shi Wen-Qing , Li Biao , Shao Yi 
Published: August 2021

Abstract
Purpose: To investigate functional connectivity density (FCD) values of brain areas in children with strabismus and amblyopia (SA) by resting-state functional magnetic resonance imaging (rs-fMRI).Methods: This study recruited 26 children (14 male, 12 female) with SA and 26 healthy children (14 male, 12 female) as healthy controls. Both groups matched in age, gender, educational level and socioeconomic background. All participants underwent fMRI scanning while resting. Visual function of participants was also evaluated by an ophthalmic examination; rs-fMRI data was then used to determine global and short-range FCD. Receiver operating characteristic curves were constructed to investigate whether there was a significant difference between children with SA and healthy controls. This experiment has passed the ethical approval and obtained the logic number cdyfy201511.Results: Global FCD values of children with SA were found to be remarkably decreased in the right cerebellum, left lenticular nucleus, putamen, and right superior frontal gyrus as compared with healthy controls; global FCD values of children with SA were increased in the right angular gyrus, left middle cingulate gyrus, left angular gyrus, right superior parietal gyrus, and right middle frontal gyrus. In children with SA, short-range FCD values were found to be remarkably decreased in regions of the middle right temporal pole, right cerebellum, left lenticular nucleus, putamen, left hippocampus, right hippocampus, left thalamus, left cerebellum; values were increased in the right superior parietal gyrus as compared with healthy controls.Conclusion: We noted abnormal neural connectivity in some brain areas of children with SA; the detailing of such connectivity aberrations is helpful in exploring the pathophysiology of SA and providing useful information for future clinical management.
Reusing of Real Textile Wastewater After Treatment by Gamma Irradiation: Implications on the Growth of Capsicum Frutescens Plant
Authors: AHSAN MD ARIFUL , Rahman M. Safiur , Bhuiyan Md. Abdul Quaiyum , Rahaman Md. Saifur , Rahman Mir Tamzid , Khan Mubarak Ahmad 
Published: August 2021

Abstract
This investigation concentrates on the possibility of using gamma radiation for the decomposition of textile wastewater and reuse as irrigation water. The real wastewater sample was irradiated at four different radiation doses of 3, 5, 8, and 10 kGy. After irradiation at 8–10 KGy, physicochemical parameters, i.e., pH, turbidity, EC, total suspended solids (TSS), total dissolved solids (TDS), biological oxygen demand (BOD5), and chemical oxygen demand (COD) have decreased sharply and approached to the expected value. At maximum 10 KGy radiation dose, 59.0 % BOD5 and 71.6 % COD removal have been achieved, accelerating the enhancement in biodegradability index (BOD5/COD, 0.43). Ammonium and total nitrogen have improved up to 87.0 % and 94.5 % after irradiation at 10 KGy doses. These treated textile wastewater samples were reused to grow Capsicum frutescens plants to inspect the fertility responses. When Capsicum plants were nourished by textile wastewater irradiated at 8–10 kGy, the dry masses of the fruits, moisture content, root length, average plant height, average number of leaves, and total number of fruits were increased in comparison to those plants nourished by simply water and raw wastewater. The elemental analysis confirmed that the heavy metals concentration in Capsicum fruits decreased gradually with higher radiation doses. Helpful macro and micronutrients for plant production such as Na, K, and Mg were raised at a sufficient level of 47.7 %, 23.5 %, and 63.8 % for 10 KGy, whereas the highest 50.0 % increase in Ca concentration was found for 8 KGy fruit samples.