bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landmarks in wayfinding: a review of the existing literature
Authors: Yesiltepe Demet , Conroy Dalton Ruth , Ozbil Torun Ayse 
Published: March 2021

AbstractLandmarks are accepted as one of the vital elements in both virtual and real environments during wayfinding tasks. This paper provides an overview of the existing literature on the selection of landmarks in wayfinding mostly in large-scale urban environments and outdoors by discussing two main aspects of landmarks: visibility and salience. Environments and layouts used in previous studies, different tasks given to people and the main findings are explained and compared. Summary tables are created from these findings. The review concludes that there is mostly a consensus on the selection of landmarks, when considering their location. Accordingly, landmarks on route and also at decision points (with a turn) are more effective during wayfinding tasks. However, visibility of landmarks as well as visual and cognitive saliency need to be further investigated using different environments, tasks or different levels of familiarity with environments.
Presentation of a rare, highly aggressive peritoneal disease: desmoplastic small round cell tumor and its therapeutic options
Authors: Ramspott Jan Philipp , Jäger Tarkan , Neureiter Daniel , Emmanuel Klaus , Schredl Philipp 
Published: March 2021

SummaryBackgroundDesmoplastic small round cell tumor is a rare highly aggressive peritoneal disease (sarcoma) with mortality rates up to 70% in the first 3 years after diagnosis. It mainly affects young men. Patients clinically complain about diffuse abdominal pain.MethodsThis case report describes the clinical course of a 69-year-old man who presented with recurrent abdominal pain. Physical examination, laboratory testing, imaging, and gastroscopy were performed. Intra-abdominal peritoneal biopsies were taken during diagnostic laparoscopy.ResultsPhysical examination was unremarkable. Laboratory results showed elevated white blood cells, C‑reactive protein, and negative tumor markers. Computed tomography and positron emission tomography scan revealed extensive peritoneal metastases with diffuse intra-abdominal signal intensities and ascites. Gastroscopy was unremarkable, whereas diagnostic laparoscopy confirmed imaging results with a peritoneal cancer index of 39. Extensive immunohistochemical and consecutive molecular investigations led to the diagnosis of an intraperitoneal desmoplastic small round cell tumor.ConclusionOur case report demonstrates a very rare cause of recurrent abdominal pain. Desmoplastic small round cell tumor is a rare and highly aggressive undifferentiated sarcoma, which mainly affects young men. Treatment options include chemotherapy, radiotherapy, cytoreductive surgery, and/or hyperthermic intraperitoneal chemotherapy. Standardized treatment protocols are still lacking because only a few cases have been described so far. Differential diagnoses include all malignancies with peritoneal masses.
Supply chain viability: conceptualization, measurement, and nomological validation
Authors: Ruel Salomée , El Baz Jamal , Ivanov Dmitry , Das Ajay 
Published: March 2021

AbstractSupply chain viability (SCV) is an emerging concept of growing importance in operations management. This paper aims to conceptualize, develop, and validate a measurement scale for SCV. SCV is first defined and operationalized as a construct, followed by content validation and item measure development. Data have been collected through three independent samplings comprising a total of 558 respondents. Both exploratory and confirmatory factor analyses are used in a step-wise manner for scale development. Reliability and validity are evaluated. A nomological model is theorized and tested to evaluate nomological validity. For the first time, our study frames SCV as a novel and distinct construct. The findings show that SCV is a hierarchical and multidimensional construct, reflected in organizational structures, organizational resources, dynamic design capabilities, and operational aspects. The findings reveal that a central characteristic of SCV is the dynamic reconfiguration of SC structures in an adaptive manner to ensure survival in the long-term perspective. This research conceptualizes and provides specific, validated dimensions and item measures for SCV. Practitioner directed guidance and suggestions are offered for improving SCV during the COVID-19 pandemic and future severe disruptions.
A local search framework for industrial test laboratory scheduling
Authors: Mischek Florian , Musliu Nysret 
Published: March 2021

AbstractIn this paper we introduce a complex scheduling problem that arises in a real-world industrial test laboratory, where a large number of activities has to be performed using qualified personnel and specialized equipment, subject to time windows and several other constraints. The problem is an extension of the well-known Resource-Constrained Project Scheduling Problem and features multiple heterogeneous resources with very general availability restrictions, as well as a grouping phase, where the jobs have to be assembled from smaller units. We describe an instance generator for this problem and publicly available instance sets, both randomly generated and real-world data. Finally, we present and evaluate different metaheuristic approaches to solve the scheduling subproblem, where the assembled jobs are already provided. Our results show that Simulated Annealing can be used to achieve very good results, in particular for large instances, where it is able to consistently find better solutions than a state-of-the-art constraint programming solver within reasonable time.
Ethical Decision-Making in Family Firms: The Role of Employee Identification
Authors: Reck Friederike Sophie , Fischer Denise , Brettel Malte 
Published: March 2021

AbstractThe ethical behavior prevalent in an organization often determines business success or failure. Much research in the business context has scrutinized ethical behavior, but there are still few insights into its roots; this study furthers this line of inquiry. In line with identity work theory, we examine how employees’ identification with a family business shapes internal ethical decision-making processes. Because it is individuals who engage in decision-making—be it ethical or not—our research perspective centers on the individual level. We followed an inductive, qualitative approach and conducted interviews with 19 employees in seven family businesses. We found that individuals engage in identity work when they identify as individual family firm employees and when they identify with the perceived characteristics of the family firm. These processes of identification, in turn, influence how employees cope with ethical situations. Our findings contribute to ethics and family business research, as well as to identity theory.
Batch seismic inversion using the iterative ensemble Kalman smoother
Authors: Gineste Michael , Eidsvik Jo 
Published: March 2021

AbstractAn ensemble-based method for seismic inversion to estimate elastic attributes is considered, namely the iterative ensemble Kalman smoother. The main focus of this work is the challenge associated with ensemble-based inversion of seismic waveform data. The amount of seismic data is large and, depending on ensemble size, it cannot be processed in a single batch. Instead a solution strategy of partitioning the data recordings in time windows and processing these sequentially is suggested. This work demonstrates how this partitioning can be done adaptively, with a focus on reliable and efficient estimation. The adaptivity relies on an analysis of the update direction used in the iterative procedure, and an interpretation of contributions from prior and likelihood to this update. The idea is that these must balance; if the prior dominates, the estimation process is inefficient while the estimation is likely to overfit and diverge if data dominates. Two approaches to meet this balance are formulated and evaluated. One is based on an interpretation of eigenvalue distributions and how this enters and affects weighting of prior and likelihood contributions. The other is based on balancing the norm magnitude of prior and likelihood vector components in the update. Only the latter is found to sufficiently regularize the data window. Although no guarantees for avoiding ensemble divergence are provided in the paper, the results of the adaptive procedure indicate that robust estimation performance can be achieved for ensemble-based inversion of seismic waveform data.
Use of sanger and next-generation sequencing to screen for mosaic and intronic APC variants in unexplained colorectal polyposis patients
Authors: Elsayed Fadwa A. , Tops Carli M. J. , Nielsen Maartje , Morreau Hans , Hes Frederik J. , van Wezel Tom 
Published: March 2021

AbstractIn addition to classic germline APC gene variants, APC mosaicism and deep intronic germline APC variants have also been reported to be causes of adenomatous polyposis. In this study, we investigated 80 unexplained colorectal polyposis patients without germline pathogenic variants in known polyposis predisposing genes to detect mosaic and deep intronic APC variants. All patients developed more than 50 colorectal polyps, with adenomas being predominantly observed. To detect APC mosaicism, we performed next-generation sequencing (NGS) in leukocyte DNA. Furthermore, using Sanger sequencing, the cohort was screened for the following previously reported deep intronic pathogenic germline APC variants: c.1408 + 731C > T, p.(Gly471Serfs*55), c.1408 + 735A > T, p.(Gly471Serfs*55), c.1408 + 729A > G, p.(Gly471Serfs*55) and c.532-941G > A, p.(Phe178Argfs*22). We did not detect mosaic or intronic APC variants in the screened unexplained colorectal polyposis patients. The results of this study indicate that the deep intronic APC variants investigated in this study are not a cause of colorectal polyposis in this Dutch population. In addition, NGS did not detect any further mosaic variants in our cohort.
Robust scheduling and dispatching rules for high-mix collaborative manufacturing systems
Authors: Zanchettin Andrea Maria 
Published: March 2021

AbstractMotivated by the increasing demand of mass customisation in production systems, this paper proposes a robust and adaptive scheduling and dispatching method for high-mix human-robot collaborative manufacturing facilities. Scheduling and dispatching rules are derived to optimally track the desired production within the mix, while handling uncertainty in job processing times. The sequencing policy is dynamically adjusted by online forecasting the throughput of the facility as a function of the scheduling and dispatching rules. Numerical verification experiments confirm the possibility to accurately track highly variable production requests, despite the uncertainty of the system.
Who’s calling? The effect of phone calls and personal interaction on tax compliance
Authors: Mogollon Monica , Ortega Daniel , Scartascini Carlos 
Published: March 2021

AbstractMost tax agencies use letters as the method of communicating with taxpayers. Still, other technologies exist that could be more effective. This paper reports the results of a field experiment conducted by the National Tax Agency of Colombia (DIAN), using phone calls to reduce tax delinquencies. DIAN randomly assigned 34,000 tax debtors to a phone call operation using a fixed script to communicate existing debts and invite taxpayers to a meeting at the local tax agency office. Phone calls were very effective to increase collection of unpaid taxes. Conditional on the phone call being made, the effect on the treatment is about 25 percentage points higher than the control group (about a fivefold increase). We also find suggestive evidence that the personal interaction seems to be an important channel for explaining taxpayers’ behavior. Faced with a tax agent, taxpayers tend to commit to attending the meeting and paying the tax owed. However, many taxpayers who commit do not make payment effective. The findings complement a nascent literature that shows that there are plenty of gains from innovating in the communication strategy. They also indicate that personal interactions are important, but they have to be paired with easy-to-follow and immediate actions. Paying taxes is easier said than done.
Strong Solutions of Stochastic Differential Equations with Generalized Drift and Multidimensional Fractional Brownian Initial Noise
Authors: Baños David , Ortiz-Latorre Salvador , Pilipenko Andrey , Proske Frank 
Published: March 2021

AbstractIn this paper, we prove the existence of strong solutions to an stochastic differential equation with a generalized drift driven by a multidimensional fractional Brownian motion for small Hurst parameters $$H<\frac{1}{2}.$$

H
<

1
2

.

Here, the generalized drift is given as the local time of the unknown solution process, which can be considered an extension of the concept of a skew Brownian motion to the case of fractional Brownian motion. Our approach for the construction of strong solutions is new and relies on techniques from Malliavin calculus combined with a “local time variational calculus” argument.
What’s so naïve about naïve realism?
Authors: Raineri Carlo 
Published: March 2021

AbstractNaïve Realism claims that veridical perceptual experiences essentially consist in genuine relations between perceivers and mind-independent objects and their features. The contemporary debate in the philosophy of perception has devoted little attention to assessing one of the main motivations to endorse Naïve Realism–namely, that it is the only view which articulates our ‘intuitive’ conception of perception. In this paper, I first clarify in which sense Naïve Realism is supposed to be ‘naïve’. In this respect, I argue that it is put forward as the only view which can take our introspective knowledge of perception at face value, and I identify the two (alleged) key features of such introspective knowledge. Second, I challenge the claim that one of these features-namely, that it seems as one could not be in the same perceptual state unless the putative objects of perception existed and were perceived–is introspectively evident. Consequently, I argue that a view of perceptual experience–such as Intentionalism–which denies that this feature is true of perception can still take introspection at face value. This undermines the claim that Naïve Realism is the only account which accommodates our intuitions on the nature of perception.
Accounting for preference dependency in target costing – a note
Authors: Homburg Carsten , Hoppe André , Schick Roman , Braul Amelie 
Published: March 2021

AbstractTarget costing is a well-established strategic cost management tool in theory and practice. The original target costing model implies independence of customer preferences resulting in additive utility functions for the customer-oriented optimization of cost structures. We argue that this independence of preferences is not given until a minimum variant of a product is reached that provides its inherent functionality. This is reasonable since one cannot assign customer utility to a product that does not function in its most basic way. Our modified model accounts for the dependency of customer preferences and differentiates between the costs necessary to produce a minimum variant and those related to product features beyond this minimum variant. The customer-oriented optimization of the cost structure is then conducted only for those costs that exceed the costs of the minimum variant. This modification justifies the preference independence assumption in target costing and allows for a more reasonable assignment of required adjustments in costs per product component.
Prognostic performance of clinical assessment tools following hip fracture in patients with chronic kidney disease
Authors: Wu Henry H. L. , Van Mierlo Reinier , McLauchlan George , Challen Kirsty , Mitra Sandip , Dhaygude Ajay P. , Nixon Andrew C. 
Published: March 2021

Abstract
Purpose
People living with chronic kidney disease (CKD) are at a higher risk of hip fracture with an associated increased mortality risk compared to individuals without CKD. Our study aimed to evaluate the clinical assessment tools that best predict mortality risk following hip fracture for patients with CKD.

Methods
Patients with CKD G3b-5D admitted to Lancashire Teaching Hospitals NHS Foundation Trust, U.K. between June 2013 and Dec 2019 were included. The association between CKD and post-fracture mortality risk was evaluated. All patients were assessed using tools that evaluated frailty status, co-morbidity, pre-operative risk, functional status and cardiopulmonary fitness. Receiver operating characteristic curve analyses were performed to determine the prognostic accuracy of the assessment tools for 30 day and 1 year mortality following hip fracture in patients with CKD.

Results
397 patients fulfilled inclusion criteria with a mean age of 83.5 ± 9.2 years. Older age, female sex, intracapsular fracture and more severe CKD, co-morbidity and frailty status were all associated with an increased mortality risk. Patients with dialysis-dependent CKD and severe/very severe frailty had a hazard ratio for mortality of 2.55 (95% Cl 2.11–2.98) and 3.11 (95% Cl 2.47–3.93), respectively. The Clinical Frailty Scale demonstrated the best prognostic accuracy for both 30 day [Area Under the Curve (AUC) 0.91, 95% Cl 0.84–0.97] and 1 year mortality (AUC 0.93, 95% Cl 0.87–1.00).

Conclusion
Patients with advanced CKD and severe frailty have a high mortality risk following hip fracture. The Clinical Frailty Scale is an excellent prognostic tool for mortality in this setting and could be easily incorporated into routine clinical practice.
Rediscovering the Cooperative Enterprise: A Systematic Review of Current Topics and Avenues for Future Research
Authors: Camargo Benavides Andres Felipe , Ehrenhard Michel 
Published: March 2021

AbstractFor decades, the cooperative enterprise (CE) produces market goods and/or provides services in the interest to its members, such as communities, customers, and suppliers. The upsurge of interest in social enterprises, and their balancing of social and economic interests, has also led to a renewed interest in CEs, often seen as a specific type of social enterprise. However, from an organizational perspective, this renewed interest has been both limited and scattered over a variety of fields. In this paper, we systematically review papers on CE in the mainstream organizational literature, defined as literature in the fields of economics, business, management and sociology. Our review integrates and synthesizes the current topics in the mainstream organizational literature and provides a number of avenues for future research. In addition, we compare our findings in the organizational literature to the social issues literature as these appeared to be quite complimentary. We found multilevel studies, determination of social impact—in particular measurable impact, managerial practices for sustainable (organisational) development, and the entrepreneurial opportunity generation process as the four key avenues for future research.
Effects of urbanisation and a wastewater treatment plant on microplastic densities along a subtropical river system
Authors: Dalu Tatenda , Banda Thabiso , Mutshekwa Thendo , Munyai Linton F. , Cuthbert Ross N. 
Published: March 2021

AbstractGlobal freshwaters are increasingly threatened by pollutants emanating from human activities around watersheds. Microplastic pollution is an increasing problem for rivers worldwide, potentially threatening ecological integrity, ecosystem services and human health. We present quantifications and characterisations of sediment microplastic pollution in a subtropical river system in southern Africa, and relate distributions to wastewater treatment works, abiotic variables and urban environments. We additionally apply several diversity indices to decipher how microplastic types differ across the river system seasonally. Over two thousand microplastic particles were found across five sites and three seasons in the river system, comprising microbeads of various colours and microfibres. Microplastic concentrations were highest and most diverse in the hot–wet (mean range 76.0 ± 10.0–285.5 ± 44.5 microplastic kg−1) season as compared to the cool–dry (16.5 ± 4.5–27.0 ± 5.0 microplastic kg−1) and hot–dry (13.0 ± 4.0–29.0 ± 10.0 microplastic kg−1) seasons, and were mostly dominated by microfibres. However, no clear patterns were found in relation to wastewater treatment operations spatially, or in relation to abiotic variables in the river system. This study therefore finds a diverse range of microplastic types widely distributed in the river system that differ across seasons. Our results provide important, novel insights into plastic pollution in an understudied area of the Global South, and point to extensive pollution from sources outside of wastewater treatment works.
Discovery and investigation of natural Diels–Alderases
Authors: Watanabe Kenji 
Published: March 2021

AbstractIt has been proposed that biosyntheses of many natural products involve pericyclic reactions, including Diels–Alder (DA) reaction. However, only a small set of enzymes have been proposed to catalyze pericyclic reactions. Most surprisingly, there has been no formal identification of natural enzymes that can be defined to catalyze DA reactions (DAases), despite the wide application of the reaction in chemical syntheses of complex organic compounds. However, recent studies began to accumulate a growing body of evidence that supports the notion that enzymes that formally catalyze DA reactions, in fact exist. In this review, I will begin by describing a short history behind the discovery and characterization of macrophomate synthase, one of the earliest enzymes that was proposed to catalyze an intermolecular DA reaction during the biosynthesis of a substituted benzoic acid in a phytopathogenic fungus Macrophoma commelinae. Then, I will discuss representative enzymes that have been chemically authenticated to catalyze DA reactions, with emphasis on more recent discoveries of DAases involved mainly in fungal secondary metabolite biosynthesis except for one example from a marine streptomycete. The current success in identification of a series of DAases and enzymes that catalyze other pericyclic reactions owes to the combined efforts from both the experimental and theoretical approaches in discovering natural products. Such efforts typically involve identifying the chemical features derived from cycloaddition reactions, isolating the biosynthetic genes that encode enzymes that generate such chemical features and deciphering the reaction mechanisms for the enzyme-catalyzed pericyclic reactions.
The legacy of large dams in the United States
Authors: Di Baldassarre Giuliano , Mazzoleni Maurizio , Rusca Maria 
Published: March 2021

AbstractThe sustainability of large dams has been questioned on several grounds. One aspect that has been less explored is that the development of dams and reservoirs often enables agricultural expansion and urban growth, which in turn increase water consumption. As such, dam development influences, while being influenced by, the spatial and temporal distribution of both supply and demand of water resources. In this paper, we explore the interplay between large dams, patterns of population growth and agricultural expansion in the United States over the past two centuries. Based on a large-scale analysis of spatial and temporal trends, we identify three distinct phases, in which different processes dominated the interplay. Then, we focus on agricultural water use in the Southwest region (Arizona, California and Nevada) and explore chicken-and-egg dynamics where water supply partly meets and partly fuels water demand. Lastly, we show that the legacy of dams in the United States consists of a lock-in condition characterized by high levels of water consumption, especially in the Southwest, which leads to severe water crises and groundwater overexploitation when droughts occur.