bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Axillary Lymph Node Metastasis in Early Breast Cancer Using Deep Learning on Primary Tumor Biopsy Slides
Authors: Xu Feng , Zhu Chuang , Tang Wenqi , Wang Ying , Zhang Yu , Li Jie , Jiang Hongchuan , Shi Zhongyue , Liu Jun , Jin Mulan 
Published: October 2021

ObjectivesTo develop and validate a deep learning (DL)-based primary tumor biopsy signature for predicting axillary lymph node (ALN) metastasis preoperatively in early breast cancer (EBC) patients with clinically negative ALN.MethodsA total of 1,058 EBC patients with pathologically confirmed ALN status were enrolled from May 2010 to August 2020. A DL core-needle biopsy (DL-CNB) model was built on the attention-based multiple instance-learning (AMIL) framework to predict ALN status utilizing the DL features, which were extracted from the cancer areas of digitized whole-slide images (WSIs) of breast CNB specimens annotated by two pathologists. Accuracy, sensitivity, specificity, receiver operating characteristic (ROC) curves, and areas under the ROC curve (AUCs) were analyzed to evaluate our model.ResultsThe best-performing DL-CNB model with VGG16_BN as the feature extractor achieved an AUC of 0.816 (95% confidence interval (CI): 0.758, 0.865) in predicting positive ALN metastasis in the independent test cohort. Furthermore, our model incorporating the clinical data, which was called DL-CNB+C, yielded the best accuracy of 0.831 (95%CI: 0.775, 0.878), especially for patients younger than 50 years (AUC: 0.918, 95%CI: 0.825, 0.971). The interpretation of DL-CNB model showed that the top signatures most predictive of ALN metastasis were characterized by the nucleus features including density (p= 0.015), circumference (p= 0.009), circularity (p= 0.010), and orientation (p= 0.012).ConclusionOur study provides a novel DL-based biomarker on primary tumor CNB slides to predict the metastatic status of ALN preoperatively for patients with EBC.
Dexmedetomidine Versus Propofol for Patients With Sepsis Requiring Mechanical Ventilation: A Systematic Review and Meta-Analysis
Authors: Huang Po , Zheng Xiangchun , Liu Zhi , Fang Xiaolei 
Published: October 2021

Purpose: This meta-analysis was performed to access the influence of dexmedetomidine versus propofol for adult patients with sepsis undergoing mechanical ventilation.Materials and Methods: NCBI PUBMED, Cochrane Library, Embase, China National Knowledge Internet (CNKI), and China Biological Medicine (CBM) were searched. Revman 5.3 and Stata software (version 12.0, Stata Corp LP, College Station, TX, United States) were used for meta-analysis.Results: Fifteen studies were included, and the data from the included studies were incorporated into the meta-analysis. Also, the result shows that compared with propofol, dexmedetomidine does not reduce 28-day mortality [risk ratios (RR) =0.97, 95% confidence interval (CI) =0.83–1.13, p = 0.70]. However, our analysis found that dexmedetomidine could reduce intensive care unit (ICU) stays {standard mean difference (SMD): −0.15; 95% CI: [−0.30–(−0.01)], p = 0.03}, duration of mechanical ventilation {SMD: −0.22; 95% CI: [−0.44–(−0.01)], p = 0.043}, sequential organ failure assessment (SOFA) {SMD: −0.41; 95% CI: [−0.73–(−0.09)], p = 0.013}, levels of interleukin-6 (IL-6) at 24 h (SMD: −2.53; 95% CI: −5.30-0.24, p = 0.074), and levels of CK-MB at 72 h {SMD: −0.45; 95% CI: [−0.83–(−0.08)], p = 0.017}.Conclusions: This meta-analysis (MA) suggests that in terms of 28-day mortality, sepsis patients with the treatment of dexmedetomidine did not differ from those who received propofol. In addition, more high-quality trials are needed to confirm these findings.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/#recordDetails, identifier CRD42021249780.
Comparison of Safety and Efficacy Between Clopidogrel and Ticagrelor in Elderly Patients With Acute Coronary Syndrome: A Systematic Review and Meta-Analysis
Authors: Zhao Xiangkai , Zhang Jian , Guo Jialin , Wang Jinxin , Pan Yuhui , Zhao Xue , Sang Wentao , Yang Kehui , Xu Fengyang , Xu Feng , Chen Yuguo 
Published: October 2021

Background: Dual antiplatelet therapy combining aspirin with a P2Y12 adenosine diphosphate receptor inhibitor is a therapeutic mainstay for acute coronary syndrome (ACS). However, the optimal choice of P2Y12 adenosine diphosphate receptor inhibitor in elderly (aged ≥65 years) patients remains controversial. We conducted a meta-analysis to compare the efficacy and safety of ticagrelor and clopidogrel in elderly patients with ACS. Methods: We comprehensively searched in Web of Science, EMBASE, PubMed, and Cochrane databases through 29th March, 2021 for eligible randomized controlled trials (RCTs) comparing the efficacy and safety of ticagrelor or clopidogrel plus aspirin in elderly patients with ACS. Four studies were included in the final analysis. A fixed effects model or random effects model was applied to analyze risk ratios (RRs) and hazard ratios (HRs) across studies, and I2 to assess heterogeneity.Results: A total number of 4429 elderly patients with ACS were included in this analysis, of whom 2170 (49.0%) patients received aspirin plus ticagrelor and 2259 (51.0%) received aspirin plus clopidogrel. The ticagrelor group showed a significant advantage over the clopidogrel group concerning all-cause mortality (HR 0.78, 95% CI 0.63–0.96, I2 = 0%; RR 0.79, 95% CI 0.66–0.95, I2 = 0%) and cardiovascular death (HR 0.71, 95% CI 0.56–0.91, I2 = 0%; RR 0.76, 95% CI 0.62–0.94, I2 = 5%) but owned a higher risk of PLATO major or minor bleeding (HR 1.46, 95% CI 1.13–1.89, I2 = 0%; RR 1.40, 95% CI 1.11–1.76, I2 = 0%). Both the groups showed no significant difference regarding major adverse cardiovascular events (MACEs) (HR 1.06, 95% CI 0.68–1.65, I2 = 77%; RR 1.04, 95% CI 0.69–1.58, I2 = 77%).Conclusion: For elderly ACS patients, aspirin plus ticagrelor reduces cardiovascular death and all-cause mortality but increases the risk of bleeding. Herein, aspirin plus ticagrelor may extend lifetime for elderly ACS patients compared with aspirin plus clopidogrel. The optimal DAPT for elderly ACS patients may be a valuable direction for future research studies.
The Use of Artificial Neural Networks to Forecast the Behavior of Agent-Based Models of Pathophysiology: An Example Utilizing an Agent-Based Model of Sepsis
Authors: Larie Dale , An Gary , Cockrell R. Chase 
Published: October 2021

Introduction: Disease states are being characterized at finer and finer levels of resolution via biomarker or gene expression profiles, while at the same time. Machine learning (ML) is increasingly used to analyze and potentially classify or predict the behavior of biological systems based on such characterization. As ML applications are extremely data-intensive, given the relative sparsity of biomedical data sets ML training of artificial neural networks (ANNs) often require the use of synthetic training data. Agent-based models (ABMs) that incorporate known biological mechanisms and their associated stochastic properties are a potential means of generating synthetic data. Herein we present an example of ML used to train an artificial neural network (ANN) as a surrogate system used to predict the time evolution of an ABM focusing on the clinical condition of sepsis.Methods: The disease trajectories for clinical sepsis, in terms of temporal cytokine and phenotypic dynamics, can be interpreted as a random dynamical system. The Innate Immune Response Agent-based Model (IIRABM) is a well-established model that utilizes known cellular and molecular rules to simulate disease trajectories corresponding to clinical sepsis. We have utilized two distinct neural network architectures, Long Short-Term Memory and Multi-Layer Perceptron, to take a time sequence of five measurements of eleven IIRABM simulated serum cytokine concentrations as input and to return both the future cytokine trajectories as well as an aggregate metric representing the patient’s state of health.Results: The ANNs predicted model trajectories with the expected amount of error, due to stochasticity in the simulation, and recognizing that the mapping from a specific cytokine profile to a state-of-health is not unique. The Multi-Layer Perceptron neural network, generated predictions with a more accurate forecasted trajectory cone.Discussion: This work serves as a proof-of-concept for the use of ANNs to predict disease progression in sepsis as represented by an ABM. The findings demonstrate that multicellular systems with intrinsic stochasticity can be approximated with an ANN, but that forecasting a specific trajectory of the system requires sequential updating of the system state to provide a rolling forecast horizon.
Effects of Low and High Aneurysmal Wall Shear Stress on Endothelial Cell Behavior: Differences and Similarities
Authors: Morel Sandrine , Schilling Sabine , Diagbouga Mannekomba R. , Delucchi Matteo , Bochaton-Piallat Marie-Luce , Lemeille Sylvain , Hirsch Sven , Kwak Brenda R. 
Published: October 2021

Background: Intracranial aneurysms (IAs) result from abnormal enlargement of the arterial lumen. IAs are mostly quiescent and asymptomatic, but their rupture leads to severe brain damage or death. As the evolution of IAs is hard to predict and intricates medical decision, it is essential to improve our understanding of their pathophysiology. Wall shear stress (WSS) is proposed to influence IA growth and rupture. In this study, we investigated the effects of low and supra-high aneurysmal WSS on endothelial cells (ECs).Methods: Porcine arterial ECs were exposed for 48 h to defined levels of shear stress (2, 30, or 80 dyne/cm2) using an Ibidi flow apparatus. Immunostaining for CD31 or γ-cytoplasmic actin was performed to outline cell borders or to determine cell architecture. Geometry measurements (cell orientation, area, circularity and aspect ratio) were performed on confocal microscopy images. mRNA was extracted for RNAseq analysis.Results: ECs exposed to low or supra-high aneurysmal WSS were more circular and had a lower aspect ratio than cells exposed to physiological flow. Furthermore, they lost the alignment in the direction of flow observed under physiological conditions. The effects of low WSS on differential gene expression were stronger than those of supra-high WSS. Gene set enrichment analysis highlighted that extracellular matrix proteins, cytoskeletal proteins and more particularly the actin protein family were among the protein classes the most affected by shear stress. Interestingly, most genes showed an opposite regulation under both types of aneurysmal WSS. Immunostainings for γ-cytoplasmic actin suggested a different organization of this cytoskeletal protein between ECs exposed to physiological and both types of aneurysmal WSS.Conclusion: Under both aneurysmal low and supra-high WSS the typical arterial EC morphology molds to a more spherical shape. Whereas low WSS down-regulates the expression of cytoskeletal-related proteins and up-regulates extracellular matrix proteins, supra-high WSS induces opposite changes in gene expression of these protein classes. The differential regulation in EC gene expression observed under various WSS translate into a different organization of the ECs’ architecture. This adaptation of ECs to different aneurysmal WSS conditions may affect vascular remodeling in IAs.
Lifetime and 1-Month Prevalence of Mental Disorders in Hebei Province, China: A Community-Based Cross-Sectional Study
Authors: Sun Long , Zhang Yunshu , Cui Lijun , Li Jianfeng , Li Lin , Sun Xiuli , Liu Yongqiao , Zhang Lili , Li Keqing 
Published: October 2021

Background: The prevalence of mental disorders is an important topic, which has been reported in different countries in the world. In China, some studies were also conducted to get the prevalence of mental disorders at the national level and in some metropolitan cities. However, the prevalence of mental disorders in Chinese underdeveloped provinces has not been reported internationally in recent decades. Due to the discrepancy in the social-economic development of different Chinese provinces, we also have reasons to believe the different prevalence of mental disorders between underdeveloped provinces and other provinces.Method: A community-based cross-sectional study was conducted among community residents aged 18 years and older in Hebei province, China. We screened 20,884 community residents in this study, and a Structured Clinical Interview for Diagnostic and Statistical Manual (DSM-IV) Axis I disorders was used to make the diagnoses of mental disorders.Results: The weighted lifetime prevalence of mental disorders was 15.87% (95% CI 15.38–16.38%), and the 1-month prevalence was 10.79% (95% CI 10.37–11.22%). Anxiety disorder ranked first in the classification of mental disorders for both lifetime (6.56%) and 1-month prevalence (6.25%). The weighted lifetime and 1-month region–gender–age-specific prevalence of mental disorders was also analyzed in this study.Conclusions: Mental disorders have been an important issue in Chinese economically underdeveloped regions, and the prevalence was at a high level compared with the results in the 2000s. There are several serious challenges in the work of Chinese mental disorders, which should be paid more attention to.
Estado del arte de la metodología CLIL desde una perspectiva métrica
Authors: Sarmiento Chugcho Kleber Oswaldo , Pizarro Johanna , Matamoros González Jessenia Anabel 
Published: October 2021

El proceso de enseñanza y aprendizaje de una lengua extranjera descansa fundamentalmente en el método de enseñanza que se utilice. Una de las metodologías más efectiva es el enfoque CLIL. El objetivo de este artículo es describir el dominio de conocimiento que se articula en torno a la metodología CLIL. Para ello se utilizaron los estudios métricos de la información como marco metodológico. Se aplicaron un grupo de indicadores de productividad, de colaboración y de impacto. El análisis se realizó en un corpus de investigaciones obtenido de la base de datos Dimensions. Los resultados alcanzados ofrecen un conjunto relaciones y estructuras que describen las particularidades de las investigaciones realizadas sobre la metodología CLIL. Entre las conclusiones expuesta se plantea que las investigaciones relacionadas con la metodología CLIL se han convertido en tendencia, desde el 2015 a la fecha es posible advertir una buena producción científica en torno a estos temas.
Trabalho de extensão como uma forma de geração de renda
Authors: Andrade Angela Leão , Amaro Rodrigo Chaves , Pessoa Letieri Fernandes , Alvarenga Meiry Edivirges 
Published: October 2021

Em uma tentativa de reduzir o alto índice de desemprego, evitar a contaminação do ambiente pelo óleo residual e melhorar a autoestima, o projeto de fabricação de sabão começou a ser realizado em Ouro Preto e, posteriormente, em um distrito de Ouro Preto. Inicialmente, para atingir esses objetivos, foram ofertados cursos sobre fabricação de sabão, meio ambiente e psicologia organizacional. Com o decorrer do projeto, foram abordados ainda os temas gestão fi nanceira e empresarial. Durante o desenvolvimento do projeto, o crescimento foi de todos: dos professores, que trabalharam com demandas reais, dos alunos, que aprenderam sobre temas variados, e da comunidade, que aprendia teorias científi cas e ensinava observações práticas. Ao fi nal, o grupo de mulheres já conseguia fazer sabão e, com a venda do produto, a renda familiar e a autoestima delas aumentaram.DOI: http://dx.doi.org/10.35700/ca.2016.ano3n5.p44-50.2056
Sarau Literarte: a socialização da leitura e da arte
Authors: De Lima Lisiane Ferreira , Ramos Twyne Soares 
Published: October 2021

O presente trabalho visa relatar a experiência com o desenvolvimento do projeto de extensão “Literarte: literatura em movimento”, que está vinculado a um projeto de maior abrangência, intitulado “Socializando a leitura”, desenvolvido pelo Instituto de Letras e Artes, da Universidade Federal do Rio Grande (FURG). O projeto envolve literatura e outras artes, como dança, desenho, fotografi a, música e teatro.DOI: http://dx.doi.org/10.35700/ca.2016.ano3n5.p88-92.2054
Peran Guru Aqidah Akhlak dalam Menanggulangi Kenakalan Siswa di MTs Hidayatus Sholihin Turus
Authors: Surur Agus Miftakus , Wulandari Titis Dwi , Fawzi Tanya , Shofa Adib Zaimatus 
Published: October 2021

Guru memiliki peran yang sangat penting dalam menanggulangi kenakalan yang terjadi pada siswa, dan berperan membentuk akhlak yang baik bagi siswa. Penelitian ini bertujuan untuk mengetahui faktor penyebab kenakalan siswa dan untuk mengetahui peran guru dalam menanggulangi kenakalan siswa kelas VIII di MTs Hidayatus Sholihin Turus (Gurah). Penelitian ini menggunakan data sebagai informasi yang lengkap dan mendalam mengenai peran guru aqidah akhlak dalam menanggulangi kenakalan siswa kelas VIII di MTs Hidayatus Sholihin Turus (Gurah) sehingga metode yang sesuai digunakan dalam penelitian ini adalah metode kualitatif. Hasil penelitian menunjukkan bahwa faktor yang mempengaruhi kenakalan siswa adalah faktor lingkungan dan pengaruh dari teman-temannya. Jenis pelanggaran yang sering dilakukan adalah merokok, membolos, dan pulang sebelum waktunya. Sementara itu guru aqidah akhlak memiliki peran dalam menanggulangi kenakalan siswa melalui proses pembelajaran dengan mengaitkan antara bab yang dipelajari dengan kehidupan sehari-hari dan bekerja sama dengan guru lainnya untuk mengambil suatu tindakan atau untuk memanggil orang tua apabila terdapat siswa yang melakukan pelanggaran cukup berat

Teachers have a very important role in overcoming delinquency that occurs in students, and play a role in forming good morals for students. This study aims to determine the factors causing student delinquency and to determine the teacher's role in tackling the delinquency of class VIII students at MTs Hidayatus Sholihin Turus (Gurah). This study uses data as complete and in-depth information about the role of aqidah moral teachers in overcoming delinquency in class VIII students at MTs Hidayatus Sholihin Turus (Gurah) so that the appropriate method used in this study is a qualitative method. The results showed that the factors that influence student delinquency are environmental factors and the influence of their friends. The types of violations that are often carried out are smoking, truancy, and coming home prematurely. Meanwhile, the Aqidah Morals teacher has a role in tackling student delinquency through the learning process by linking the chapters studied with everyday life and collaborating with other teachers to take an action or to call parents if there are students who commit serious violations.
TINJAUAN ETIKA BISNIS ISLAM PADA MEKANISME PENJUALAN BIBIT IKAN LELE SISTEM TIMBANGAN (Islamic Business Ethics Analysis in The Selling Mechanism of the Juvenile Catfish Weights System)
Authors: Zunaidi Arif , Febriani Elisa Fitri , Khalik Jamaludin A 
Published: October 2021

Usaha budidaya ikan lele saat ini semakin variatif. sejalan dengan kemajuan zaman dan teknologi, prinsipnya cenderung menggunakan lahan seminimal mungkin agar mendapatkan hasil yang maksimal. Dalam praktiknya, ada model jual beli bibit lele yang menggunakan timbangan. Penelitian mengunakan metode kualitatif dengan metode observasi untuk melihat fakta yang terjadi di lapangan. Data yang terkumpul dianalisis menggunakan menggunakan metode analisis penelitian deskriptif. Tujuan Penelitian untuk megetahui bagaimana praktik jual beli bibit ikan lele sistem timbangan dalam perspektif Etika Bisnis Islam. Hasil penelitian mengungkapkan bahwa Praktik jual beli bibit ikan lele yang terjadi di Dusun Tawang ini jika dilihat dari segi ketauhidan sebenarnya telah memenuhi rukun dan syarat dalam jual beli. Dalam kaitannnya dengan etika bisnis islampun tidak ada pelanggaran berat. Namun dalam prosesnya masih ada kecurangan yang dilakukan pembeli yaitu menimbang dengan tidak adil. Selebihnya sudah sesuai dengan etika bisnis islam.
Catfish farming is currently increasingly varied. In line with the advancement of times and technology, the principle tends to use as little land as possible in order to get maximum results. In practice, there is a model for selling catfish seeds that uses scales. This research uses qualitative methods with observational methods to see the facts that occur in the field. The collected data were analyzed using descriptive research analysis method. The research objective was to find out how to practice selling catfish seeds with a weighing system in the perspective of Islamic Business Ethics. The results of the study revealed that the practice of buying and selling catfish seeds that occurred in Tawang, when viewed from the perspective of monotheism, actually fulfilled the pillars and requirements in buying and selling. In relation to Islamic business ethics, it is not heavy. However, in the process there is still fraud committed by buyers, namely weighing unfairly. The rest is in accordance with Islamic business ethics.
FAKTOR YANG BERHUBUNGAN DENGAN PENGGUNAAN KONTRASEPSI SUNTIK 3 BULAN DIWILAYAH PUSKESMAS TAGULANDANG KABUPATEN SITARO
Authors: Karimang Sriwulan , Abeng T.D. E. , Silolonga Wico N. 
Published: October 2021

Abstract: 3-month KB injection is a hormonal contraceptive method that contains etherogens. This contraception works by preventing egg release so that there will be no fertilization of the egg by sperm. One injection is given every three months and the injection is very effective if routinely given in a timely manner. Method: This study used a cross sectional study design with a population of all mothers who used 3-month injection contraception in the Tagulandang Health Center, Sitaro District. Sampling was done by non-probability sampling with pruposive sampling technique. The number of samples is 38 respondents. Data is presented in the form of Frequency Tables. Data analysis used is univariate and bivariate analysis using the chi-square analysis method. The results of the study: based on the characteristics showed that most respondents chose the use of 3-month injection contraception, respondents aged 20-35 years received support from husbands with good incomes. From the chi-square test results obtained ρ value for age ρ = 0.02 less than α = 0.05, ρ value for husband support ρ = 0.04 less than α = 0.05, ρ value for income ρ = 0 .01 is smaller than α = 0.05. In conclusion, the results of this study indicate that there is a significant relationship between age, husband support, income and injecting contraceptive use in 3-month injection contraception in the Tagulandang Community Health Center, Sitaro Regency. Keywords: Age, Husband Support, Income.Abstrak: Suntik KB 3 bulan adalah metode kontrasepsi hormonal yang mengandung eterogen. Kontrasepsi ini bekerja dengan mencegah pengeluaran sel telur sehinggah tidak akan terjadi pembuahan sel telur oleh sperma. Satu suntikan di berikan setiap tiga bulan dan suntikan tersebut sangat efektif apabila rutin di berikan secara tepat waktu. Metode: Penelitian ini menggunakan desain penelitian cros sectional dengan populasi seluruh ibu yang menggunakan kontrasepsi suntik 3 bulan diwilayah Puskesmas Tagulandang Kabupaten Sitaro. Pengambilan sampel dilakukan secara non probability sampling dengan teknik pruposive sampling. Jumlah sampel sebanyak 38 responden. Data disajikan dalam bentuk Frequency Table, Analisis data yang digunakan adalah analisis univariat dan bivariat dengan menggunakan metode analisis chi-square. Hasil penelitian: Berdasarkan karakteristik menunjukkan sebagian besar responden memilih penggunaan kontrasepsi suntik 3 bulan, responden memiliki usia 20-35 tahun mendapat dukungan dari suami dengan pendapatan yang baik. Dari hasil uji chi-square didapatkan hasil nilai ρ untuk usia ρ = 0,02 lebih kecil dari α = 0,05, nilai ρ untuk dukungan suami ρ = 0.04 lebih kecil dari α = 0,05, nilai ρ untuk pendapatan ρ = 0,01 lebih kecil dari α = 0,05. Kesimpulan, hasil penelitian ini menunjukan ada hubungan yang bermakna antara Usia, Dukungan suami, Pendapatan dengan Penggunaan Kontrasepsi Suntik 3 bulan di Wilayah Puskesmas Tagulandang Kabupaten Sitaro.Kata Kunci: Usia, Dukungan Suami, Pendapatan.