bluuebunny/crossref_metadata_2025_split huggingface dataset:
El trabajo no es una mercancía. Contenido y sentido del trabajo en el siglo XXI
Authors: SUPIOT Alain 
Published: February 2021

ResumenEn su clase magistral de clausura como profesor del Collège de France, Alain Supiot invita a un replanteamiento de la justicia social y del sentido del trabajo. La crisis social y ecológica no se superará desmontando el Estado social, sino reconsiderando su arquitectura, cuya piedra angular es el estatus que se dé al trabajo. Frente a la quiebra moral, social, ecológica y financiera del neoliberalismo, el horizonte del trabajo es su emancipación del imperio de la mercancía. Las formas de trabajo que resisten al Mercado Total, como la investigación, no son «fósiles» destinados a desaparecer, sino la simiente de un régimen de trabajo realmente humano que contemple su sentido y su contenido, es decir, la obra realizada.
Seeing Things in Black‐and‐White: A Scoping Review on Dichotomous Thinking Style1
Authors: Bonfá‐Araujo Bruno , Oshio Atsushi , Hauck‐Filho Nelson 
Published: February 2021

AbstractDichotomous thinking is a propensity for individuals to understand events as opposites, in a binary way. There are currently two inventories that accurately measure this construct, the Dichotomous Thinking Inventory, and the Dichotomous Thinking in Eating Disorders Scale. The present study aimed to carry out a review process to compile all the empirical studies that have made use of either of these instruments. To achieve this goal, we carried out a scoping review. We conducted a search using the keywords “Dichotomous Thinking Inventory,” “Dichotomous Thinking in Eating Disorders Scale,” and “Thinking Style” in the databases PubMed, Science Direct, and PsycInfo. No limits were imposed on the review. We found 19 articles that met the pre‐established criteria; the concentration of research occurred in the last 10 years. It was possible to clarify that the dichotomous way of understanding events occurs, in general, in the presence of maladaptive traits of personality.
Epidermolytic epidermal nevus caused by a somatic mutation in KRT2
Authors: Mohamad Janan , Samuelov Liat , Assaf Sari , Vodo Dan , Sarig Ofer , Sprecher Eli 
Published: February 2021

AbstractSuperficial epidermolytic ichthyosis (formerly Ichthyosis bullosa of Siemens) is an uncommon condition caused by dominant mutations in KRT2 encoding keratin 2. Epidermolytic epidermal nevus due to somatic mutations in KRT2 is even rarer. Here, we report the third case of KRT2‐associated epidermal nevus and review the literature.
Development of a RAPD marker‐based classification criterion for quality semen production in Holstein crossbred bulls
Authors: Hussain Shaziya , Alex Rani , Alyethodi Rafeeque R. , Sharma Shalini , Verma Nitika , Sirohi Ajayvir Singh , Singh Umesh , Kumar Sushil , Chand Naimi , Sengar Gyanendra S. , Sharma Ankur , Tyagi Rachna , Arya Sarmesh , Tyagi Srikant 
Published: February 2021

AbstractIn cattle production systems, an intense selection pressure for production traits has resulted in the decline of fertility traits. To optimize an efficient reproduction system, the inclusion of both male and female fertility traits in the selection process is very much essential. RAPD (Random Amplified Polymorphic DNA) was developed as a molecular biology tool and has been extensively used, to study intra‐ and interspecific genetic diversity. The present study was undertaken to utilize RAPD primers to investigate the association between DNA markers and semen quality traits viz. Sperm concentration, total sperm count ejaculate and initial sperm motility and thereby to identify good/poor semen producers. DNA isolated from the blood samples of healthy bulls was subjected to RAPD‐PCR. The multiple regression analysis followed by independent t test was carried out to identify suitable markers. Based on the results, only 12 bands were identified as marker suitable for any of the quality trait. This includes, OPA2 ~ 760, OPA2 ~ 700, OPA6 ~ 1,200, OPA9 ~ 400, OPA9 ~ 380, OPA12 ~ 970, OPA14 ~ 715, OPA14 ~ 605, OPA16 ~ 485, OPA17 ~ 860 and OPA18 ~ 480. Multiple regression analysis selected, OPA2 ~ 760 and OPA2 ~ 1,750 for sperm concentration and OPA2 ~ 760, OPA2 ~ 700, OPA9 ~ 620, OPA4 ~ 670 and OPA18 ~ 1,015 for total sperm count/ejaculate. But the t test revealed a significant association between OPA2 ~ 760 and total sperm count. Further, discriminant function analysis also identified this marker in the first step itself. The results of the present study can be exploited as a low‐cost alternative strategy for identification of good /poor semen producers in crossbred bulls at an early age.
Effects of chronic exercise on the inhibitory control of children and adolescents: A systematic review and meta‐analysis
Authors: Amatriain‐Fernández Sandra , Ezquerro García‐Noblejas Milagros , Budde Henning 
Published: February 2021

Inhibitory control is a main component of executive functions that relate to the ability to control prepotent responses and to resist interferences. Deficits in inhibitory control have been associated with numerous disorders, but exercise has become a promising approach to benefit this domain. This systematic review and meta‐analysis aims to provide synthesized information and effect size calculations of the benefits of chronic exercise interventions on the inhibitory control of healthy children and adolescents. A systematic search of PubMed, PsycINFO, MEDLINE, ERIC, SPORTDiscus, and PsycArticles identified 4166 articles to be screened for eligibility. A total of 10 studies (3138 participants) met the inclusion criteria. A random‐effects analysis model was performed in three variables: accuracy, reaction time and combined scores. The results showed a very small but statistically significant effect in accuracy (d = 0.14, 95% CI 0.01 to 0.27, P =.04), and two almost null effects (statistically non‐significant), in the reaction time (d = 0.03, 95% CI −0.10 to 0.16, P =.62) and the combined scores (d = 0.06, 95% CI −0.03 to 0.15, P =.17). Despite the high number of studies that reported positive outcomes, this meta‐analysis found only modest benefits in the inhibitory control of healthy children and adolescents after they participated in different chronic exercise interventions. The strict inclusion criteria of this study and the high variability in the designs of the exercise interventions included, among other reasons, might explain the obtained results.
Utility of an Isometric Midthigh Pull Test to Assess Lower Body Muscular Strength in Professional Netball Players
Authors: Hogarth Luke , McKean Mark , McKenzie Max , Collings Tyler 
Published: February 2021

Purpose: This study established the relationship between isometric midthigh pull (IMTP) peak force and court-based jumping, sprinting, and change of direction (COD) performance in professional netball players. The change in IMTP peak force in response to sport-specific training was also examined. Methods: IMTP peak force and court-based jumping, sprinting, and COD were collected in 18 female athletes contracted to a Suncorp Super Netball team. Linear regression models established the relationship between absolute and normalized strength values and court-based performance measures in the participant cohort. Changes in IMTP peak force and court-based performance measures were examined following 2 consecutive preseason training blocks in a subset of participants. Results: The IMTP peak force values normalized to body mass were found to be determinants of court-based jumping, sprinting, and COD performance in the participant cohort (R2 = .34–.65, P ≤ .016). The participants showed increases in absolute (mean ± SE = 398 ± 68.5 N, P < .001, Hedge g = 0.70 [−0.05 to 1.35]) and normalized IMTP peak force (mean ± SE = 4.6 ± 0.78 N·kg−1, P < .001, Hedge g = 0.47 [−0.04 to 0.97]) over 2 consecutive training blocks that coincided with improvements in jumping, sprinting, and COD performances. Conclusion: IMTP peak force is a determinant of court-based jumping, sprinting, and COD performance and is sensitive to training in professional netball players. These results support the utility of the IMTP test to monitor the development and maintenance of maximal lower body muscular strength in these athletes.
The impact of nonminimal universal extra dimensional model on $$\Delta B=2$$ transitions
Authors: Shaw Avirup 
Published: February 2021

AbstractWe measure the impact of nonvanishing boundary localised terms on $$\Delta B=2$$

Δ
B
=
2

transitions in five-dimensional Universal Extra Dimensional scenario where masses and coupling strengths of several interactions of Kaluza–Klein modes are significantly modified with respect to the minimal counterpart. In such scenario we estimate the Kaluza–Klein contributions of quarks, gauge bosons and charged Higgs by evaluating the one-loop box diagrams that are responsible for the $$\Delta B=2$$

Δ
B
=
2

transitions. Using the loop function (obtained from one-loop box diagrams) we determine several important elements that are involved in Wolfenstein parametrisation. Moreover, with these elements we also study the geometrical shape of unitarity triangle. Besides, we compute the quantity $$\Delta M_s$$

Δ

M
s

scaled by the corresponding Standard Model value. Outcomes of our theoretical predictions have been compared to the allowed ranges of the corresponding observables simultaneously. Our current analysis shows that, depending on the parameters in this scenario the lower limit on the inverse of the radius of compactification can reach to an appreciable large value ($$\approx 1.48$$

≈
1.48

TeV or even higher).
Circulating Biomarkers of Inflammation and Ovarian Cancer Risk in the Nurses' Health Studies
Authors: Peres Lauren C. , Townsend Mary K. , Birmann Brenda M. , Conejo-Garcia Jose R. , Kim Yongjoo , Kubzansky Laura D. , Magpantay Larry I. , Martinez-Maza Otoniel , Tworoger Shelley S. 
Published: February 2021

AbstractBackground:Chronic inflammation is a well-established mechanism of ovarian carcinogenesis; however, the specific immunogenic processes influencing ovarian tumor development remain unclear. In a case–control study nested within the Nurses' Health Study (NHS) and the NHSII, we examined the association between six inflammatory chemokines and cytokines [B-cell activating factor (BAFF), C-X-C motif chemokine ligand 13 (CXCL13), IL8, soluble(s)IL2-receptor-α(Rα), sIL6Rα] and epithelial ovarian cancer risk.Methods:Among 299 epithelial ovarian cancer cases and 334 matched controls, six inflammatory biomarkers were measured in plasma collected 1–24 years before diagnosis or index date using two custom multiplex Luminex panels. ORs and 95% confidence intervals (CI) were estimated for the association between each biomarker and risk using multivariable conditional logistic regression with adjustment for relevant confounders. We additionally assessed heterogeneity in the risk associations by histotype [high-grade serous carcinoma (HGSC) vs. non-HGSC], body mass index, smoking status, menopausal status, and aspirin use.Results:Women with the highest versus lowest quartile (Q) levels of CXCL13 had a 72% increased ovarian cancer risk (OR = 1.72; 95% CI = 1.04–2.83; Ptrend = 0.007). The positive association with CXCL13 was stronger in magnitude for non-HGSC, overweight or obese women, and postmenopausal women, although only menopausal status demonstrated statistically significant heterogeneity (Pinteraction = 0.04). The remaining biomarkers were not associated with risk.Conclusions:This first evidence that prediagnostic CXCL13, a B-cell chemoattractant, is associated with an increased risk of epithelial ovarian cancer expands current understanding of the role of inflammation in ovarian carcinogenesis.Impact:CXCL13 may represent a novel biomarker for ovarian cancer.
Cesarean Section Is Associated with an Increased Risk of Acute Lymphoblastic Leukemia and Hepatoblastoma in Children from Minnesota
Authors: Williams Lindsay A. , Richardson Michaela , Spector Logan G. , Marcotte Erin L. 
Published: February 2021

Abstract

Background:
In recent decades, Cesarean section (C-section) rates have increased. C-section is hypothesized to negatively impact the developing immune system by altering activation of the hypothalamic–pituitary–adrenal axis and the infant microbiome, among other mechanisms, thereby potentially modulating childhood cancer risk.

Methods:
Using linked birth and cancer registry data from Minnesota (1976–2014), we included individuals ages 0–14 at diagnosis with one of 19 cancers. Cases and controls were frequency matched by birth year. We used logistic regression to estimate ORs and 95% confidence intervals (95% CI) as the measure of association between C-section and cancer. We assessed sex–C-section interactions for each cancer and conducted stratified analyses in acute lymphoblastic leukemia (ALL) for birth year, age at diagnosis, and maternal race.

Results:
There were 3,166 cases and 20,589 controls. One third (n = 1,174) of controls born during 2004–2014 were delivered via C-section compared with 42.2% of cases (n = 285). C-section was associated with ALL (n = 819; OR: 1.20; 95% CI: 1.01–1.43) and hepatoblastoma (n = 50; OR: 1.89; 95% CI: 1.03–3.48), particularly among females (ALL OR: 1.34; 95% CI: 1.04–1.72; hepatoblastoma OR: 3.87; 95% CI: 1.30–11.57). The risk of ALL was highest during 2005–2014 (OR: 1.62; 95% CI: 1.11–2.34) and among children ages 1–5 years (OR: 1.28; 95% CI: 1.02–1.61).

Conclusions:
C-section was associated with an increased risk of ALL and hepatoblastoma.

Impact:
These associations require investigation to determine causality and rule out confounding by indication or reverse causality. The mechanisms underlying these associations may depend on neonatal immune system processes altered during C-section deliveries.
Continuing to Broaden Eligibility Criteria to Make Clinical Trials More Representative and Inclusive: ASCO–Friends of Cancer Research Joint Research Statement
Authors: Kim Edward S. , Uldrick Thomas S. , Schenkel Caroline , Bruinooge Suanna S. , Harvey R. Donald , Magnuson Allison , Spira Alexander , Wade James L. , Stewart Mark D. , Vega Diana Merino , Beaver Julia A. , Denicoff Andrea M. , Ison Gwynn , Ivy S. Percy , George Suzanne , Perez Raymond P. , Spears Patricia A. , Tap William D. , Schilsky Richard L. 
Published: February 2021

Abstract

Purpose:
Restrictive clinical trial eligibility criteria (EC) limit the number of patients who can enroll and potentially benefit from protocol-driven, investigational treatment plans and reduce the generalizability of trial results to the broader population. Following publication of expert stakeholder recommendations for broadening EC in 2017, the American Society of Clinical Oncology (ASCO) and Friends of Cancer Research (Friends) convened working groups to produce additional recommendations and analyze the potential impact on clinical trials using real-world data.

Experimental Design:
Multistakeholder working groups were appointed by an ASCO-Friends leadership group to propose recommendations for more inclusive EC related to: washout periods, concomitant medications, prior therapies, laboratory reference ranges and test intervals, and performance status.

Results:
The four working groups, ASCO Board of Directors, and Friends leadership support the recommendations included in this statement to modernize EC related to washout periods, concomitant medications, prior therapies, laboratory references ranges and test intervals, and performance status to make trial populations more inclusive and representative of cancer patient populations.

Conclusions:
Implementation of the recommendations is intended to result in greater ease of determining patient eligibility. Increased opportunities for patient participation in research will help address longstanding underrepresentation of certain groups in clinical trials and produce evidence that is more informative for a broader patient population. More patients eligible will also likely speed clinical trial accrual.
See related commentary by Giantonio, p. 2369
Rapid Resistance of FGFR-driven Gastric Cancers to Regorafenib and Targeted FGFR Inhibitors can be Overcome by Parallel Inhibition of MEK
Authors: Lau David K. , Luk Ian Y. , Jenkins Laura J. , Martin Andrew , Williams David S. , Schoffer Kael L. , Chionh Fiona , Buchert Michael , Sjoquist Katrin , Boussioutas Alex , Hayes Sarah A. , Ernst Matthias , Weickhardt Andrew J. , Pavlakis Nick , Tebbutt Niall C. , Mariadason John M. 
Published: February 2021

Abstract
Amplification or overexpression of the FGFR family of receptor tyrosine kinases occurs in a significant proportion of gastric cancers. Regorafenib is a multikinase inhibitor of angiogenic and oncogenic kinases, including FGFR, which showed activity in the randomized phase II INTEGRATE clinical trial in advanced gastric cancer. There are currently no biomarkers that predict response to this agent, and whether regorafenib is preferentially active in FGFR-driven cancers is unknown. Through screening 25 gastric cancer cell lines, we identified five cell lines that were exquisitely sensitive to regorafenib, four of which harbored amplification or overexpression of FGFR family members. These four cell lines were also sensitive to the FGFR-specific inhibitors, BGJ398, erdafitinib, and TAS-120. Regorafenib inhibited FGFR-driven MAPK signaling in these cell lines, and knockdown studies confirmed their dependence on specific FGFRs for proliferation. In the INTEGRATE trial cohort, amplification or overexpression of FGFRs 1–4 was detected in 8%–19% of cases, however, this was not associated with improved progression-free survival and no objective responses were observed in these cases. Further preclinical analyses revealed FGFR-driven gastric cancer cell lines rapidly reactivate MAPK/ERK signaling in response to FGFR inhibition, which may underlie the limited clinical response to regorafenib. Importantly, combination treatment with an FGFR and MEK inhibitor delayed MAPK/ERK reactivation and synergistically inhibited proliferation of FGFR-driven gastric cancer cell lines. These findings suggest that upfront combinatorial inhibition of FGFR and MEK may represent a more effective treatment strategy for FGFR-driven gastric cancers.
Predictors, Type, and Impact of Bleeding on the Net Clinical Benefit of Long‐Term Ticagrelor in Stable Patients With Prior Myocardial Infarction
Authors: Magnani Giulia , Ardissino Diego , Im KyungAh , Budaj Andrzej , Storey Robert F. , Steg P. Gabriel , Bhatt Deepak L. , Cohen Marc , Oude Ophius Ton , Goudev Assen , Parkhomenko Alexander , Kamensky Gabriel , Angiolillo Dominick J. , López‐Sendón José , Johanson Per , Braunwald Eugene , Sabatine Marc S. , Bonaca Marc P. 
Published: February 2021

Background
Ticagrelor reduces ischemic risk but increases bleeding in patients with prior myocardial infarction. Identification of patients at lower bleeding risk is important in selecting patients who are likely to derive more favorable outcomes versus risk from this strategy.

Methods and Results

PEGASUS‐TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin—Thrombolysis in Myocardial Infarction 54) randomized 21 162 patients with prior myocardial infarction in a 1:1:1 fashion to ticagrelor 60 mg or 90 mg twice daily or placebo, with ticagrelor 60 mg approved for long‐term use. TIMI major or minor bleeding was the primary end point for this analysis. Causes of bleeding were categorized by site and etiology, and independent predictors were identified. At 3 years, ticagrelor 60 mg increased the rate of TIMI major or minor bleeding by 2.0% versus placebo (1.4% placebo versus 3.4% ticagrelor). The bleeding excess was driven primarily by spontaneous gastrointestinal bleeds. A history of spontaneous bleeding requiring hospitalization and the presence of anemia were independent predictors of bleeding but not of ischemic risk. Patients with at least 1 risk predictor had 3‐fold higher rates of bleeding with ticagrelor 60 mg versus those who had neither (absolute risk increase, 4.4% versus 1.5%;
P
=0.01). Patients with neither predictor had a more favorable benefit profile with ticagrelor 60 mg versus placebo including lower mortality (hazard ratio, 0.79; 95% CI, 0.65–0.96;
P
interaction = 0.03).

Conclusions
In patients with prior myocardial infarction, bleeding with ticagrelor 60 mg twice daily is predominantly spontaneous gastrointestinal. A history of spontaneous bleeding requiring hospitalization or the presence of anemia identifies patients at higher risk of bleeding, and the absence of either identifies patients likely to have a more favorable net benefit with ticagrelor.

Registration

URL
https://www.clinicaltrials.gov/
. Unique identifier: NCT01225562.
The Unintended Consequences of Employer Credit Check Bans for Labor Markets
Authors: Cortés Kristle R. , Glover Andrew , Tasci Murat 
Published: February 2021

Abstract
Over the past fifteen years, eleven states have restricted employers' access to the credit reports of job applicants. We estimate that county-level job vacancies have fallen by 5.5% in occupations affected by these laws relative to exempt occupations in the same counties and national-level vacancies for the same occupations. Cross-sectional heterogeneity suggests that employers use credit reports as signals of a worker's ability to perform the job: vacancies fall more in counties with a large share of subprime residents and less for occupations with other commonly available signals. Vacancies fall most for occupations involving routine tasks, suggesting that credit reports contain information relevant for these types of jobs.
Advertisement calls of the lesser spiny frog Quasipaa exilispinosa (Liu and Hu, 1975) (Anura: Dicroglossidae)
Authors: CHEN ZHI-QIANG , HU HUA-LI , ZHONG JUN-JIE , SHANGGUAN HAI-PING 
Published: February 2021

There are currently only eleven species of Quasipaa (Anura: Dicroglossidae) distributed in southern and southwestern China to central Vietnam, southeastern Thailand, and southwestern Cambodia and presumably also in Laos (Frost 2020). Eight species of Quasipaa are currently known in China: Q. boulengeri (Günther 1889), Q. courtoisi (Angel 1922), Q. exilispinosa (Liu & Hu 1975), Q. jiulongensis (Huang & Liu 1985), Q. shini (Ahl 1930), Q. spinosa (David 1875), Q. yei (Chen, Qu, and Jiang 2002), and Q. verrucospinosa (Bourret 1937). The first seven species are endemic to China (AmphibiaChina 2020). These species have similar morphological traits and are capable of introgressive hybridization between the closely related species of this genus(Zhang et al. 2018). Despite the detailed acoustic analysis that is available to identify a variety of species and is beneficial to the study of anuran taxonomy (e.g., Microhyla species; Chen et al. 2020), advertisement calls have only been reported in detail for Q. spinosa (Yu & Zheng 2009; Chen et al. 2012; Shen et al. 2015) and Q. shini (Kong et al. 2016), whereas the call for Q. exilispinosa was briefly described from observations in captivity (Voitel 2000).