bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sudden cardiac death in childhood hypertrophic cardiomyopathy is best predicted by a combination of electrocardiogram risk‐score and HCMRisk‐Kids score
Authors: Östman‐Smith Ingegerd , Sjöberg Gunnar , Alenius Dahlqvist Jenny , Larsson Per , Fernlund Eva 
Published: July 2021

AbstractAimTo compare risk algorithms (HCMRisk‐Kids, ECG Risk‐score) in hypertrophic cardiomyopathy (HCM) without syndrome association (ns‐HCM) and with Noonan‐like syndromes (RAS‐HCM).MethodsA national paediatric HCM cohort (n = 151), presenting <19 years of age, mean follow‐up 13.3 years, from all Swedish centres of Paediatric Cardiology (presenting 1972–2015), with 41 RAS‐HCM patients (61% males), and 110 ns‐HCM patients (68% familial; 65% males). The end‐point was a composite of sudden cardiac death and resuscitated cardiac arrest (SCD/CA). Risk‐factors were studied with Cox‐hazard regression, and receiver operating characteristic curve analysis (C‐statistic).ResultsThere were 33 SCD/CA, 27/110 in ns‐HCM and 6/41 in RAS‐HCM (p = 0.27). In ns‐HCM HCMRisk‐Kids ≥6% at diagnosis had C‐statistic of 0.69 for predicting SCD/CA during first 5 years of follow‐up and positive predictive value (PPV) of 22%. After 7 years of age (HCMRisk‐Kids7plus), C‐statistic was 0.76. ECG Risk‐score ≥6 at diagnosis had C‐statistic 0.87 and PPV of 31%. Independent risk factors for SCD/CA were HCMRisk‐Kids7plus score (p = 0.005) and ECG risk‐score (p < 0.001), whereas early beta‐blocker dose (p = 0.001) and myectomy (p = 0.004) reduced risk. The sum of HCMRisk‐Kids7yplus and ECG Risk‐score7yplus ≥14 best predicted SCD/CA within 5 years in ns‐HCM with C‐statistic of 0.90 [0.83–0.96], sensitivity 100% and PPV 38%.ConclusionCombining the ECG Risk‐score with HCMRisk‐Kids improves risk stratification in ns‐HCM and shows promise in RAS‐HCM.
Does Corporate Social Responsibility Enhance Financial Performance? Evidence from Australia
Authors: Nguyen Van Ha , Agbola Frank W. , Choi Bobae 
Published: July 2021

AbstractDespite the heightened interest in corporate social responsibility (CSR) in recent years, the question of whether CSR affects a firm's financial performance remains unresolved. Using a sample of Australian publicly listed firms over the period 2009–2015, we find that CSR enhances financial performance. The positive relationship is more pronounced in mining firms than it is in non‐mining firms. However, the financial benefit of CSR is negatively moderated by the level of industry competition. These empirical findings remain robust after controlling for sample selection bias and endogeneity and employing alternative variable measures and estimation methods. Overall, our findings highlight the importance of industry characteristics in explaining the effects of CSR on financial performance.
A circulating subset of BRAFV600E‐positive cells in infants with high‐risk Langerhans cell histiocytosis treated with BRAF inhibitors
Authors: Poch Rita , Le Louet Solenne , Hélias‐Rodzewicz Zofia , Hachem Nawa , Plat Geneviève , Barkaoui Mohamed‐Aziz , Lapillonne Hélène , Delhommeau François , Emile Jean‐François , Donadieu Jean , Héritier Sébastien 
Published: July 2021

SummaryBRAF inhibitors are an effective treatment for BRAFV600E‐mutated, risk‐organ‐positive Langerhans cell histiocytosis (RO+ LCH). However, cell‐free BRAFV600E DNA often persists during therapy and recurrence frequently occurs after therapy discontinuation. To identify a pathological reservoir of BRAFV600E‐mutated cells, we studied peripheral blood cells obtained from six infants with RO+ multisystem (MS) LCH that received targeted therapy. After cell sorting, the BRAFV600E mutation was detected in monocytes (n = 5), B lymphocytes (n = 3), T lymphocytes (n = 2), and myeloid and plasmacytoid dendritic cells (n = 2 each). This biomarker may offer an interesting tool for monitoring the effectiveness of new therapeutic approaches for weaning children with RO+ LCH from targeted therapy.
Antibiotic–cell‐penetrating peptide conjugates targeting challenging drug‐resistant and intracellular pathogenic bacteria
Authors: Zeiders Samantha M. , Chmielewski Jean 
Published: July 2021

AbstractThe failure to treat everyday bacterial infections is a current threat as pathogens are finding new ways to thwart antibiotics through mechanisms of resistance and intracellular refuge, thus rendering current antibiotic strategies ineffective. Cell‐penetrating peptides (CPPs) are providing a means to improve antibiotics that are already approved for use. Through coadministration and conjugation of antibiotics with CPPs, improved accumulation and selectivity with alternative and/or additional modes of action against infections have been observed. Herein, we review the recent progress of this antibiotic–cell‐penetrating peptide strategy in combatting sensitive and drug‐resistant pathogens. We take a closer look into the specific antibiotics that have been enhanced, and in some cases repurposed as broad‐spectrum drugs. Through the addition and conjugation of cell‐penetrating peptides to antibiotics, increased permeation across mammalian and/or bacterial membranes and a broader range in bacterial selectivity have been achieved.
Whole genome sequencing identifies rare germline variants enriched in cancer related genes in first degree relatives of familial pancreatic cancer patients
Authors: Tan Ming , Brusgaard Klaus , Gerdes Anne‐Marie , Mortensen Michael Bau , Detlefsen Sönke , Schaffalitzky de Muckadell Ove B. , Joergensen Maiken Thyregod 
Published: July 2021

AbstractFirst‐degree relatives (FDRs) of familial pancreatic cancer (FPC) patients have increased risk of developing pancreatic ductal adenocarcinoma (PDAC). Investigating and understanding the genetic basis for PDAC susceptibility in FPC predisposed families may contribute toward future risk‐assessment and management of high‐risk individuals. Using a Danish cohort of 27 FPC families, we performed whole‐genome sequencing of 61 FDRs of FPC patients focusing on rare genetic variants that may contribute to familial aggregation of PDAC. Statistical analysis was performed using the gnomAD database as external controls. Through analysis of heterozygous premature truncating variants (PTV), we identified cancer‐related genes and cancer‐driver genes harboring multiple germline mutations. Association analysis detected 20 significant genes with false discovery rate, q < 0.05 including: PALD1, LRP1B, COL4A2, CYLC2, ZFYVE9, BRD3, AHDC1, etc. Functional annotation showed that the significant genes were enriched by gene clusters encoding for extracellular matrix and associated proteins. PTV genes were over‐represented by functions related to transport of small molecules, innate immune system, ion channel transport, and stimuli‐sensing channels. In conclusion, FDRs of FPC patients carry rare germline variants related to cancer pathogenesis that may contribute to increased susceptibility to PDAC. The identified variants may potentially be useful for risk prediction of high‐risk individuals in predisposed families.
Effects of human footprint and biophysical factors on the body‐size structure of fished marine species
Authors: Bosch Nestor E. , Monk Jacquomo , Goetze Jordan , Wilson Shaun , Babcock Russell C. , Barrett Neville , Clough Jock , Currey‐Randall Leanne M. , Fairclough David V. , Fisher Rebecca , Gibbons Brooke A. , Harasti David , Harvey Euan S. , Heupel Michelle R. , Hicks Jamie L. , Holmes Thomas H. , Huveneers Charlie , Ierodiaconou Daniel , Jordan Alan , Knott Nathan A. , Malcolm Hamish A. , McLean Dianne , Meekan Mark , Newman Stephen J. , Radford Ben , Rees Matthew J. , Saunders Benjamin J. , Speed Conrad W. , Travers Michael J. , Wakefield Corey B. , Wernberg Thomas , Langlois Tim J. 
Published: July 2021

AbstractMarine fisheries in coastal ecosystems in many areas of the world have historically removed large‐bodied individuals, potentially impairing ecosystem functioning and the long‐term sustainability of fish populations. Reporting on size‐based indicators that link to food‐web structure can contribute to ecosystem‐based management, but the application of these indicators over large (cross‐ecosystem) geographical scales has been limited to either fisheries‐dependent catch data or diver‐based methods restricted to shallow waters (<20 m) that can misrepresent the abundance of large‐bodied fished species. We obtained data on the body‐size structure of 82 recreationally or commercially targeted marine demersal teleosts from 2904 deployments of baited remote underwater stereo‐video (stereo‐BRUV). Sampling was at up to 50 m depth and covered approximately 10,000 km of the continental shelf of Australia. Seascape relief, water depth, and human gravity (i.e., a proxy of human impacts) were the strongest predictors of the probability of occurrence of large fishes and the abundance of fishes above the minimum legal size of capture. No‐take marine reserves had a positive effect on the abundance of fishes above legal size, although the effect varied across species groups. In contrast, sublegal fishes were best predicted by gradients in sea surface temperature (mean and variance). In areas of low human impact, large fishes were about three times more likely to be encountered and fishes of legal size were approximately five times more abundant. For conspicuous species groups with contrasting habitat, environmental, and biogeographic affinities, abundance of legal‐size fishes typically declined as human impact increased. Our large‐scale quantitative analyses highlight the combined importance of seascape complexity, regions with low human footprint, and no‐take marine reserves in protecting large‐bodied fishes across a broad range of species and ecosystem configurations.
Burden of disease experienced by patients following a watch‐and‐wait policy for locally advanced rectal cancer: A qualitative study
Authors: Pennings Alexander J. , Kimman Merel L. , Gielen Anke H. C. , Beets Geerard L. , Melenhorst Jarno , Breukink Stephanie O. 
Published: July 2021

AbstractAimPatient‐reported outcome measures (PROMs) are increasingly being used in routine cancer care to evaluate treatment and monitor symptoms, function and other aspects of quality of life (QoL). There is no suitable PROM for rectal cancer patients following a watch‐and‐wait (W&W) programme. Insight into patient experiences with this programme is an essential step in the development of a PROM. The aim of this qualitative study was to provide insights into the most important functional outcomes and QoL features experienced by patients during our W&W programme.MethodPatients with locally advanced rectal cancer who are enrolled in the W&W programme in the Netherlands were interviewed by telephone using a semistructured interview guide. All interviews were digitally audio‐recorded, transcribed verbatim and coded. A thematic approach was used to analyse the data and identify themes and subthemes of importance to patients.ResultsEighteen patients were interviewed (78% male, mean age 68 years, range 52–83 years). Physical complaints after treatment were present, most notably gastrointestinal problems, neuropathy and fatigue. Furthermore, patients were anxious about a possible recurrence, had a fear of surgery or a stoma, or were experiencing a general feeling of apprehension in daily life. Many patients had different coping mechanisms, such as acceptance, and there were few limitations in daily life.ConclusionWe identified important functional outcomes, such as gastrointestinal complaints, fatigue and neuropathy, in patients who were enrolled in this W&W programme. Furthermore, an emotional burden and unmet needs were reported by these patients. These findings can be used to improve clinical practice and inform the development of a PROM.
Certified community forests positively impact human wellbeing and conservation effectiveness and improve the performance of nearby national protected areas
Authors: Loveridge Robin , Sallu Susannah M , Pfeifer Marion , Oldekop Johan A , Mgaya Mercy , da Silva Daniel A , Latham Julia , Platts Philip J , Marshall Andrew R 
Published: July 2021

AbstractCommunity forests (CFs) aim to improve human wellbeing and conservation effectiveness, though their performance remains contested. A recent innovation in protected area (PA) governance is to combine CFs with forest certification. We assess (1) the impact of certified CFs on wellbeing and conservation effectiveness; (2) gender inequality and elite capture; (3) interaction effects with neighboring national PAs. We used a novel approach that integrates field data consisting of locally identified indicators representative of multidimensional wellbeing, with remotely sensed data on conservation effectiveness and statistical matching to improve causal inference. We found that CFs positively impacted wellbeing, conservation effectiveness, and reduced gender inequality, though they did not reduce elite capture. We also detected positive interaction effects between certified CFs and neighboring national PAs. Our findings suggest that locating contrasting local and national PA governance approaches next to each other may help to maximize wellbeing and conservation benefits within complex multiuse landscapes.
Putting the cat before the wildlife: Exploring cat owners' beliefs about cat containment as predictors of owner behavior
Authors: van Eeden Lily M. , Hames Fern , Faulkner Richard , Geschke Andrew , Squires Zoe E. , McLeod Emily M. 
Published: July 2021

AbstractFree‐roaming domestic cats pose risks to wildlife, domestic animals, humans, and importantly, the cats themselves. Behavior change campaigns that seek to minimize these risks by increasing cat containment require an understanding of the factors that predict cat owners' containment behaviors. We conducted an online survey in Victoria, Australia (N = 1,024) to identify cat owners' (N = 220) behaviors in containing their cats, explore beliefs and attitudes that predict containment behavior, and compare attitudes about cat containment with respondents that do not own cats (N = 804). We found that 53% of cat owning respondents do not allow any roaming. These respondents were more likely to hold concerns about risks to cats' safety while roaming and less likely to perceive that cats have a right to roam. Concern about impacts to wildlife was not a significant predictor of containment behavior. Expectations that cat owners should manage cats' roaming behavior was a social norm among cat owners and other respondents, and cat containers were more likely to indicate that they would try to change behaviors of their peers that they perceived to be harmful to the environment. Cat containment campaigns could be improved by appealing to owners' concerns about cat well‐being, engaging respected messengers that align with these concerns, including owners who already contain their cats.
Climate relict vulnerable to extinction from multiple climate‐driven threats
Authors: Taillie Paul J. , McCleery Robert A. 
Published: July 2021

AbstractAimOver the gradually warming Holocene, many species’ range limits shifted poleward. However, some populations persisted in climate refugia, such as mountain tops. These climate relict populations are critical components of regional biodiversity, but their isolation renders them vulnerable to other threats, including changes in environmental conditions indirectly related to a warming global climate. We aimed to quantify the role of these indirect climate effects on Florida saltmarsh vole (Microtus pennsylvannicus dukecampbelli; hereafter: “vole”), a poorly understood, endangered climate relict.LocationThe Gulf of Mexico between Sopchoppy and Pine Island, Florida, USA.MethodsWe surveyed for voles broadly across their potential range using camera traps and modelled the relationships between vole occurrence and two climate‐driven threats: hurricane storm surge and shifting vegetation communities. We quantified these threats using both field‐collected and remotely sensed data at fine (3‐m) and coarse (150‐m) spatial scales.ResultsThough seemingly suitable habitat exists outside their previously known range, voles appeared restricted to the outer marshes between the Suwannee and Withlacoochee Rivers. Within this range, the sites we surveyed had shorter grass heights, greaterDistichilsspp. cover, greater potential habitat within 150 m, and were less vulnerable to inundation when compared to sites outside of their range.Main conclusionsThe complex and varied ways in which climate change alters the physical environment can expose small‐ranging species to multiple threats. Even climate relicts, which have endured historical changes in the global climate, may fail to cope with the rapid pace of anthropogenic climate change.
Isoprostane‐8 and GDF‐15 as novel markers of post‐PE syndrome: Relation with prothrombotic factors
Authors: Ząbczyk Michał , Natorska Joanna , Janion‐Sadowska Agnieszka , Metzgier‐Gumiela Agnieszka , Polak Mateusz , Plens Krzysztof , Janion Marianna , Skonieczny Grzegorz , Mizia‐Stec Katarzyna , Undas Anetta 
Published: July 2021

AbstractBackgroundPost–pulmonary embolism (PE) syndrome occurs in up to 50% of PE patients. The pathophysiology of this syndrome is obscure.ObjectiveWe investigated whether enhanced oxidative stress and prothrombotic state may be involved in post‐PE syndrome.MethodsWe studied 101 normotensive noncancer PE patients (aged 56.5 ± 13.9 years) on admission, after 5‐7 days and after a 3‐month anticoagulation, mostly with rivaroxaban. A marker of oxidative stress, 8‐isoprostane, endogenous thrombin potential, fibrinolysis proteins, clot lysis time (CLT) and fibrin clot permeability (Ks), along with PE biomarkers, were determined.ResultsPatients who developed the post‐PE syndrome (n = 31, 30.7%) had at baseline 77.6% higher N‐terminal brain natriuretic propeptide and 46.8% higher growth differentiation factor 15, along with 14.1% longer CLT associated with 34.4% higher plasminogen activator inhibitor‐1 as compared to subjects without post‐PE syndrome (all P < .05). After 5‐7 days, only hypofibrinolysis was noted in post‐PE syndrome patients. When measured at 3 months, prolonged CLT and reduced Ks were observed in post‐PE syndrome patients, accompanied by 23.8% higher growth differentiation factor 15 and 35.8% higher plasminogen activator inhibitor‐1 (all P < .05). 8‐isoprostane levels ≥108 pg/ml (odds ratio=4.36; 95% confidence interval 1.63‐12.27) and growth differentiation factor 15 ≥ 1529 pg/ml (odds ratio=3.89; 95% confidence interval 1.29‐12.16) measured at 3 months were associated with higher risk of developing post‐PE syndrome.ConclusionsEnhanced oxidative stress and prothrombotic fibrin clot properties could be involved in the pathogenesis of the post‐PE syndrome. Elevated growth differentiation factor 15 assessed at 3 months might be a new biomarker of this syndrome.
The economics of change and stability in social trust: Evidence from (and for) Catalan secession
Authors: Bjørnskov Christan , Borrella‐Mas Miguel Ángel , Rode Martin 
Published: July 2021

AbstractConsequences of social trust are comparatively well studied, while its societal determinants are often subject to debate. This paper studies both in the context of Catalan attempts to secede from Spain: First, we test whether Catalonia enjoys higher levels of social capital that it is prevented from capitalizing on. Second, the paper examines whether secessionist movements create animosity and political divisions within society that undermine trust. Employing the nine available waves of the European Social Survey for Spain, we only find weak indications that social trust levels are higher in Catalonia than in the rest of the country. Interestingly, we further find testimony of a purely transient “exuberance effect” after secession became a real option, indicating that the long‐run evolution of social trust may best be thought of as a stable punctuated equilibrium.
A reduced‐sucrose diet increases the sensitivity of Drosophila melanogaster to radiation
Authors: Kim Yongjoong , Park Jina , Choi You Yeon , Lee Younghyun , Seo Songwon , Jin Young Woo , Park Sunhoo , Min Kyung‐Jin , Seong Ki Moon 
Published: July 2021

AbstractDrosophila melanogaster has been increasingly used as an experimental model to understand the health effects of environmental stresses such as radiation exposure and the nutrients depletion. Few studies have examined the physiological changes of radiation exposure combined with other condition such as nutrient depletion. To understand the effects of radiation exposure in the context of poor diet, this study investigated the effects of a sucrose‐deficient diet on the development and life span of Drosophila after radiation exposure. On a low‐sucrose diet (0.1 M), the life span of Drosophila increased strongly after 0.05 Gy radiation exposure, compared to nonirradiated flies, whereas life span was decreased after 1 Gy. These phenomena were more pronounced in female flies than in males. Collectively, these data indicate that a low‐sucrose diet can increase sensitivity to perturbations in life span caused by radiation exposure.
No Greater Love
Authors: Borthwick Kirsty 
Published: July 2021

AbstractIt is in overcoming the powers of death that Christ’s love moves the world to reconciliation and unity. This article examines three present global crises – COVID‐19, climate change, and racial injustice – from the context of Western Europe, exploring how Christ’s love first overcomes the powers of death and then calls us to our own death to self, in pursuit of reconciliation and unity. 2 Corinthians 5:14a, a key inspiration for the theme of the 11th Assembly of the World Council of Churches, sets the movement of Christ’s love in the context of his death and resurrection, in which we share. Taking seriously Christ’s encounter with the powers of death, and our abiding in that love, has pertinent consequences for how we understand movements toward reconciliation and unity in Western Europe today.
A Letter to My Family across the World
Authors: Carvalhaes Cláudio 
Published: July 2021

AbstractThis article reflects on the theme of the 2022 assembly of the World Council of Churches, “Christ’s love moves the world to reconciliation and unity.” It names some of the main forces that pull us away from Christ’s love, that promote enmity rather than reconciliation and division rather than unity, starting with colonization and capitalism. It then moves on to emergence and regeneration, where God’s healing is needed to regenerate the tissues of our society, our hearts, our faith, our ways of living, and our collective life. We must turn to the earth in ways we never have before. We must heed God’s call; we need to listen, to follow. We need a conversion that regenerates us.
Building a Reconciled Community
Authors: Audu Victor 
Published: July 2021

AbstractThe church lives as the reconciled community, which means that the life of the church should display the proper response of humanity to the work of God. To be reconciled to God means to enter into reconciliation with all peoples, nations, and tribes. Paul, in his letter to Philemon, is active in witnessing to the reality of reconciliation. This was a drifting away from slavery. He remained resolute in the establishment of justice. In this manner, the apostle also seeks to establish unity and pave the way for peace within the household church. In the difficult and complex situation posed by the text, Paul’s witness includes bringing to light Onesimus’ wrongdoing while at the same time testifying to the power of forgiveness and the call to Philemon and those of the household church to live reconciled lives before God. Paul advocates this through the acts of love to remove the breaches of communion. Entering into actions of reconciliation witnesses to a common commitment to live in obedience to the reconciling God and therefore opens the actors to the possibility of entering into the reality of healing.