bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naturalness implications within the two-real-scalar-singlet beyond the SM
Authors: Aali Jamal Ou , Manaut Bouzid , Rahili Larbi , Semlali Souad 
Published: November 2021

AbstractThe aim of this study is to investigate the quadratic divergences using dimensional regularization within the context of the Standard Model (SM) extended by two real scalar singlets (TRSM). This extension provides three neutral scalar fields that mix, after developing itsVEVs, leading to three CP-even Higgs bosons, namely,$$h_1$$h1,$$h_2$$h2and$$h_3$$h3, which would offer a wide phenomenology at the Large Hadron Collider (LHC), as reported recently. Furthermore, to fulfill the Veltman conditions for those three fields, we concentrate on the one-loop level ($$d_L=2$$dL=2) of dimensional regularization calculations, assuming$$R_{\xi }$$RξFeynman–’t Hooft gauge-invariant,$$\xi =1$$ξ=1. We show that the divergence cancellation could take place in the framework of the TRSM for the SM-like Higgs boson predicting a stringent constraint on the space parameters as well as the new physics (NP) scale, and yet remain consistent with current experimental measurements at 13 TeV.
Instability of a liquid sheet with viscosity contrast in inertial microfluidics
Authors: Patel Kuntal , Stark Holger 
Published: November 2021

AbstractFlows at moderate Reynolds numbers in inertial microfluidics enable high throughput and inertial focusing of particles and cells with relevance in biomedical applications. In the present work, we consider a viscosity-stratified three-layer flow in the inertial regime. We investigate the interfacial instability of a liquid sheet surrounded by a density-matched but more viscous fluid in a channel flow. We use linear stability analysis based on the Orr–Sommerfeld equation and direct numerical simulations with the lattice Boltzmann method (LBM) to perform an extensive parameter study. Our aim is to contribute to a controlled droplet production in inertial microfluidics. In the first part, on the linear stability analysis we show that the growth rate of the fastest growing mode$$\xi ^{*}$$ξ∗increases with the Reynolds number$$\text {Re}$$Reand that its wavelength$$\lambda ^{*}$$λ∗is always smaller than the channel widthwfor sufficiently small interfacial tension$$\Gamma $$Γ. For thin sheets we find the scaling relation$$\xi ^{*} \propto mt^{2.5}_{s}$$ξ∗∝mts2.5, wheremis viscosity ratio and$$t_{s}$$tsthe sheet thickness. In contrast, for thicker sheets$$\xi ^{*}$$ξ∗decreases with increasing$$t_s$$tsormdue to the nearby channel walls. Examining the eigenvalue spectra, we identify Yih modes at the interface. In the second part on the LBM simulations, the thin liquid sheet develops two distinct dynamic states: waves traveling along the interface and breakup into droplets with bullet shape. For smaller flow rates and larger sheet thicknesses, we also observe ligament formation and the sheet eventually evolves irregularly. Our work gives some indication how droplet formation can be controlled with a suitable parameter set$$\{\lambda ,t_{s},m,\Gamma ,\text {Re}\}$${λ,ts,m,Γ,Re}.Graphical Abstract
Thermophysical and structural properties of manganese ferrite nanoparticles
Authors: Gochuyeva A. F. 
Published: November 2021

This paper discusses the results of the research carried out to study the structure, optical properties and thermophysical properties of a sample (nanopowder with a true density of 4.96 g/cm3, a particle size of 60 nm and a purity of 98.5%, SkySpring Nanomaterials, USA) with high purity. Based on the results of X-ray diffraction, the crystalline phase of MnFe2O4ferrite nanoparticles was completely obtained and the values of the lattice parameters were determined. The results of the MID-IR analysis showed that the absorption coefficient [Formula: see text] reaches its maximum value at 748 cm[Formula: see text] wave number. The optical properties of the as-prepared nanostructures were also investigated by VERTEX 70 V diffuse reflectance spectroscopy (DRS). As can be seen from the results of the DSC analysis, the effects occurring in the temperature range up to [Formula: see text]C clearly reflect the nature of the phase transitions and the amount of energy generated in the ferrite samples.
A Jurassic flower bud from China
Authors: Cui Da-Fang , Hou Yemao , Yin Pengfei , Wang Xin 
Published: November 2021

Abstract

Angiosperms may be distinguished from their gymnosperm peers by their flowers, and thus a flower is a good proxy of fossil angiosperms. However, flowers and their parts are usually too frail to be preserved in the fossil record. This makes the origin of angiosperms and their flowers the foci of controversy in botany. Eliminating such botanical controversies can only be achieved by studying related plant fossils. Applying routine scanning electron microscopy, light microscopy and micro-computed tomography (micro-CT) technologies, we document a fossil flower bud,
Florigerminis jurassica
gen. et sp. nov., from the Jurassic of Inner Mongolia, China. This fossil includes not only a leafy branch but also physically connected fruit and flower bud. The developmentally interpolated existence of a blooming flower between the flower bud and mature fruit in
Florigerminis
suggests that angiosperm flowers were present in the Jurassic, in agreement with recent botanical progress.
Florigerminis jurassica
underscores the presence of angiosperms in the Jurassic and demands a rethinking of angiosperm evolution.
Design and Evaluation of a Tunable PUF Architecture for FPGAs
Authors: Streit Franz-Josef , Krüger Paul , Becher Andreas , Wildermann Stefan , Teich Jürgen 
Published: November 2021

FPGA-based Physical Unclonable Functions (PUF) have emerged as a viable alternative to permanent key storage by turning effects of inaccuracies during the manufacturing process of a chip into a unique, FPGA-intrinsic secret. However, many fixed PUF designs may suffer from unsatisfactory statistical properties in terms of uniqueness, uniformity, and robustness. Moreover, a PUF signature may alter over time due to aging or changing operating conditions, rendering a PUF insecure in the worst case. As a remedy, we propose
CHOICE
, a novel class of FPGA-based PUF designs with tunable uniqueness and reliability characteristics. By the use of addressable shift registers available on an FPGA, we show that a wide configuration space for adjusting a device-specific PUF response is obtained without any sacrifice of randomness. In particular, we demonstrate the concept of address-tunable propagation delays, whereby we are able to increase or decrease the probability of obtaining “
1
”s in the PUF response. Experimental evaluations on a group of six 28 nm Xilinx Artix-7 FPGAs show that CHOICE PUFs provide a large range of configurations to allow a fine-tuning to an average uniqueness between 49% and 51%, while simultaneously achieving bit error rates below 1.5%, thus outperforming state-of-the-art PUF designs. Moreover, with only a single FPGA slice per PUF bit, CHOICE is one of the smallest PUF designs currently available for FPGAs. It is well-known that signal propagation delays are affected by temperature, as the operating temperature impacts the internal currents of transistors that ultimately make up the circuit. We therefore comprehensively investigate how temperature variations affect the PUF response and demonstrate how the tunability of CHOICE enables us to determine configurations that show a high robustness to such variations. As a case study, we present a cryptographic key generation scheme based on CHOICE PUF responses as device-intrinsic secret and investigate the design objectives resource costs, performance, and temperature robustness to show the practicability of our approach.
Intelligent Recognition Algorithm-Based Color Doppler Ultrasound in the Treatment of Dangerous Placenta Previa
Authors: Zheng Xiaoxiao , Li Xiaoqiong , Xu Jinxia , Wei Yunbo 
Published: November 2021

The study focused on the clinical diagnostic value of color Doppler ultrasound of dangerous placenta previa patients under the guidance of intelligent recognition algorithms. 58 patients with placenta previa and placenta accreta admitted to the hospital for treatment were selected as research subjects. The color Doppler ultrasound under the guidance of intelligent recognition algorithm was compared with the two-dimensional ultrasound for specificity, sensitivity, and accuracy. The color Doppler ultrasound results showed that, of the 58 patients, there were 32 cases of complete placenta previa and 26 cases of incomplete placenta previa, which were consistent with the surgical pathology results. It was found that patients with malignant placenta previa and placenta accreta had thickened placenta, disappeared posterior placental space, myometrium <2 mm, and increased incidence of cervical enlargement (

P

< 0.05). In conclusion, the recognition accuracy of color Doppler ultrasound under the guidance of the intelligent recognition algorithm is more than 90%, and it can effectively identify dangerous placenta previa, assisting doctors in diagnosis and treatment of dangerous placenta previa.
Anlotinib Induces a T Cell–Inflamed Tumor Microenvironment by Facilitating Vessel Normalization and Enhances the Efficacy of PD-1 Checkpoint Blockade in Neuroblastoma
Authors: Su Yudong , Luo Bingying , Lu Yao , Wang Daowei , Yan Jie , Zheng Jian , Xiao Jun , Wang Yangyang , Xue Zhenyi , Yin Jie , Chen Peng , Li Long , Zhao Qiang 
Published: November 2021

Abstract

Purpose:
Anlotinib has achieved good results in clinical trials of a variety of cancers. However, the effects of anlotinib on the tumor microenvironment (TME) and systemic immunity have not been reported. There is an urgent need to identify the underlying mechanism to reveal new opportunities for its application in neuroblastoma (NB) and other cancers. Understanding the mechanism will hopefully achieve the goal of using the same method to treat different cancers.

Experimental Design:
This study used bioinformatics, NB syngeneic mouse models, flow cytometry, RNA-seq, and immunofluorescence staining to explore the mechanisms of anlotinib on the TME, and further explored anlotinib-containing combination treatment strategies.

Results:
We proved that anlotinib facilitates tumor vessel normalization at least partially through CD4+ T cells, reprograms the immunosuppressive TME into an immunostimulatory TME, significantly inhibits tumor growth, and effectively prevents systemic immunosuppression. Moreover, the combination of anlotinib with a PD-1 checkpoint inhibitor counteracts the immunosuppression caused by the upregulation of PD-L1 after monotherapy, extends the period of vascular normalization, and finally induces NB regression.

Conclusions:
To our knowledge, this study is the first to dynamically evaluate the effect of a multitarget antiangiogenic tyrosine kinase inhibitor on the TME. These findings have very important clinical value in guiding the testing of related drugs in NB and other cancers. Based on these findings, we are conducting a phase II clinical study (NCT04842526) on the efficacy and safety of anlotinib, irinotecan, and temozolomide in the treatment of refractory or relapsed NB, and hopefully we will observe patient benefit.
Progestin Significantly Inhibits Carcinogenesis in the Mogp-TAg Transgenic Mouse Model of Fallopian Tube Cancer
Authors: Nelson Omar L. , Rosales Rebecca , Turbov Jane M. , Thaete Larry G. , Cline J. Mark , Rodriguez Gustavo C. 
Published: November 2021

Abstract

Recent studies suggest that the fallopian tube epithelium (FTE) harbors the precursor for high-grade ovarian cancer, creating opportunities for targeting the FTE for ovarian cancer prevention. Preclinical evidence supports progestins as ovarian cancer preventives, but the effect of progestins on the FTE is not well characterized. The murine oviduct–specific glycoprotein promotor-driven simian virus 40 large T-Antigen (mogp-TAg) transgenic mouse model develops neoplastic lesions in the fallopian tube in a manner similar to that described in human fallopian tube and ovarian cancers. In this study, we investigated the inhibitory effects of the progestin depo-medroxyprogesterone acetate (DMPA) on fallopian tube carcinogenesis following treatment for 3 and 7 weeks in 5-week-old mogp-TAg mice. Overall, compared with vehicle-treated mice, the fallopian tube of DMPA-treated mice was significantly smaller (P &lt; 0.0005), accumulated fewer p53-positive cells, had normal distribution of ciliated cells, less nuclear pleomorphism and epithelial tufting, and had a significantly lower proliferative index (P = 0.001). Accumulation of p53 signatures and serous tubal intraepithelial carcinomas (STIC) in the fallopian tube was significantly reduced in the DMPA (P &lt; 0.0005) treatment group. Moreover, the fallopian tube of the DMPA-treated mice developed significantly less adenocarcinoma compared with vehicle (P &lt; 0.005) at both treatment time points. DMPA treatment significantly induced cleaved caspase-3 (P &lt; 0.0005) in the FTE compared with vehicle suggesting that apoptosis is involved in DMPA-related clearance of abnormal cells from the fallopian tube. These data demonstrate that DMPA targets early events in fallopian tube carcinogenesis by clearing genetically damaged cells, leading to marked reduction in adenocarcinoma, supporting progestins as chemopreventive agents for fallopian tube and ovarian cancers.

Prevention Relevance:
The fallopian tube is thought to harbor the cell of origin for most ovarian cancers. We show in a mouse model of fallopian tube cancer that progestin eradicates the earliest known precancerous lesions and markedly inhibits fallopian tube carcinogenesis, adding to growing preclinical evidence supporting progestins as potent ovarian cancer chemopreventive agents.
SIGNIFICANCE OF DETECTION OF FREE/TOTAL PSA RATIO AND OTHER BIOCHEMICAL PARAMETERS IN PATIENTS WITH BPH, CARCINOMA PROSTATE AND ITS CLINICOPATHOLOGIC CORRELATION
Authors: Joshi S. , Tilak M. A. , Jadhav S. 
Published: November 2021

Background. Benign prostatic hyperplasia (BPH) can raise prostate-specific antigen (PSA) levels two to three times higher than the normal level. An increased PSA level does not indicate Prostate Cancer (PCa), but the higher the PSA level, the higher the chance of having PCa. Detection and treatment have been profoundly affected by the advent of Free/Total PSA ratio testing.
Objectives. The aim of the study was to estimate free, total PSA levels and its ratio for serum levels of calcium, acid phosphatase and alkaline phosphatase in patients with BPH and PCa; to correlate clinical, biochemical and histopathological findings in the above patients.
Methods. PSA levels were detected by Chemiluminescent assay; serum calcium – by Modified Arsenazo method; serum acid phosphatase – by Doumas et al method; and Alkaline phosphatase – by Lowry et al method.
Results. Present study found high levels of total PSA in BPH and PCa. Levels of free PSA were high in BPH as compared to PCa rate. Free/Total PSA ratio is reduced considerably in PCa as compared to BPH. Serum acid phosphatase and alkaline phosphatase were considerably higher in PCa as compared to BPH. Serum calcium levels did not show significant difference in control and study groups.
Conclusions. It was established that patients with PCa have a greater fraction of bound PSA and a lower percentage of free PSA than in those without PCa. Therefore, in clinical practice Free/Total PSA ratio helps clinicians to decide if a biopsy is necessary.
Objectives: The study was carried out with the following objectives: to estimate free, total PSA levels and calculate Free/Total PSA ratio in patients with BPH and Carcinoma Prostate, to study the serum levels of calcium, acid phosphates, and alkaline phosphatase in patients with BPH and PCa. and to correlate clinical, biochemical and histopathological findings in the above patients.
Methods. Free and total PSA levels were detected by Chemiluminescent assay; Serum Calcium was detected by Modified Arsenazo method. Serum acid phosphatase was detected by Doumas et al method and Alkaline phosphatase were detected by Lowry et al method
Results: Present study found high levels of Total PSA in BPH and PCa. Levels of free PSA were high in BPH as compared to PCa ate. Free /Total PSA ratio is reduced considerably in PCa as compared to BPH. Serum acid phosphatase and alkaline phosphatase were slightly raised in PCa as compared to BPH. Serum calcium levels did not show a significant difference in control and study groups.
Conclusion: We concluded that patients with PCa have a greater fraction of bound PSA and a lower percentage of free PSA than in men without PCa. There was a negative correlation found between the free/total PSA ratio and the histopathologic findings. The lower the ratio higher is the grade of malignancy. Therefore in clinical practice Free/Total PSA ratio helps clinicians to decide if a biopsy is necessary
Por uma radicalidade concreta: Henry Flynt contra a vanguarda
Authors: Trochmann Bruno , Paraguai Luisa 
Published: November 2021

Relegado a notas de rodapé da história do Fluxus e cena pós-Cage de Nova Iorque, Henry Flynt desenvolveu, entre 1960 e 1966, uma abordagem crítica da vanguarda a partir de postura revolucionária, procurando respostas para perguntas que seus contemporâneos artistas aparentemente ignoravam. Trabalhamos aqui com três textos que radicalizam um discurso crítico à vanguarda que vai de uma crítica formalista até uma crítica total de caráter anticolonial e marxista. Estes três momentos são apresentados em rounds, um para cada enfrentamento com a vanguarda, passando por suas estruturas formal, social e política, em um percurso que vai do abstrato ao concreto e se manifesta em uma práxis revolucionária.
Retrato sem parede
Authors: Silva Claudinei Roberto da 
Published: November 2021

Neste artigo, o artista, curador e educador Claudinei Roberto da Silva entrelaça experiência pessoal, reconstrução histórica e análise social, de modo a delinear um quadro da presença do negro no Brasil na área da cultura, nas instituições de arte, no sistema educativo, entre outros. Nessa trama, o autor recorda as contribuições de nomes como Clóvis Moura, Abdias do Nascimento, Lélia Gonzalez, Emanoel Araujo, Sidney Amaral, Kabengele Munanga e do Movimento Negro Unificado. Dessa forma, revela os avanços da luta antirracista e por direitos sociais, ao mesmo tempo que pontua os impasses e contradições que ainda lhe são impostos – sem, contudo, perder de vista o horizonte utópico da ação.
Why Do Muslim Youths Participate in Environmental Volunteering?
Authors: Rahman Norshariani Abd , Abdul Rahman Alya Nasuha , Syed-Abdullah Sharifah Intan Sharina , Halim Lilia , Syed Zakaria Sharifah Zarina , Ahmad Abdul Razaq 
Published: November 2021

Abstract
Understanding youth environmental volunteering participation is a crucial strategy for building a citizenry that can contribute to environmental conservation efforts. Thus, this research investigated the environmental volunteering values orientation held by Malay Muslim youths in Malaysia that motivated them to engage in environmental volunteering programmes. This study started with semi-structured interviews which were then followed by a survey. The interviews were conducted with 10 participants who are environmental volunteers. Based on the interview findings, a questionnaire was developed and distributed to 267 Malay Muslim environmental volunteers. The results revealed there are four values highly held by the Malay Muslim environmental volunteers that motivated them to participate in environmental volunteering, namely religious, biospheric, altruistic, and egoistic values, in that order. For this reason, there is a need to integrate religious values in environmental volunteering program to encourage communities to jointly engage in environmental conservation efforts.
Compassion and Self-Concern in Halakhic Environmental Decision-Making
Authors: Yoreh Tanhum 
Published: November 2021

Abstract
The prevailing stance in Jewish orthodoxy is that environmental issues are extra-legal and not under the purview of halakhah (Jewish law). While considered important, environmental protection falls only under “midat haḥasidut” (extraordinary piety). This ultimately translates into environmental protection being treated as non-obligatory and only under the purview of righteous behavior rather than obligation. This has created a significant barrier to halakhically driven environmental decision-making. I argue that this worldview emerges from the process of conceptualizing the prohibition of bal tashḥit—“waste not,” the prohibition against wastefulness originating in Deuteronomy 20:19. This verse gave rise to two worldviews: one which was prioritized of not destroying the environment out of compassion for the non-human world, and another marginalized worldview that emphasized a self-concerned environmentalism which equates harm to the environment as self-harm. Privileging this latter worldview creates a pathway to advance Jewish legal discourse and align it with mainstream environmentalism.
Patent and innovation during the Industrial Revolution in England
Authors: Liu Deming 
Published: November 2021

Summary
The article explores the role of patent or lack thereof in Josiah Wedgwood’s business. It first discusses the motive behind his opposition of extension of Richard Champion’s patent and then delves into his defence of his own patent in the dispute with the alleged infringer. It aims to show the incongruence of words and deeds of a tradesman with respect to patents; more importantly, it sets out to demonstrate that the claim of patent as an incentivising measure does not bear out as far as Wedgwood is concerned; rather, it is lack of patent protection that facilitates innovation in his pottery business.
Doctor or Monster? The Pink Tide and Its Aftermath
Authors: Barbosa dos Santos Fabio Luis , Feldmann Daniel 
Published: November 2021

The recent evolution of capitalism has shifted the ground on which developmentalism stood as a civilizing utopia in Latin America, making the neodevelopmentalism that inspired different nuances of progressivism in the twenty-first century an idea “out of place.” Starting from this premise, the notions of progressivism as regression and containment as accelerating desocialization form the foundations of an interpretation of the Pink Tide that emphasizes the contradictions inherent in its own dynamics, which reinforced the neoliberal rationale. The attempt to govern social tensions through containment of the ongoing dissociative movement did not stop the regression of the structure of production and the intensification of a self-destructive social dynamic. Progressivism is revealed as a political rationale that is different from but not contradictory to its opponents in a reality in which capital governs as a totalizing extraparliamentary force. A evolução recente do capitalismo modificou as bases materiais que davam sentido ao desenvolvimentismo como utopia civilizatória na América Latina, tornando o neodesenvolvimentismo que inspirou diferentes nuances de progressismo no século XXI, uma ideia fora do lugar. A partir desta premissa, são discutidas as noções de progressismo como regressão e de contenção como aceleracion de dissocializacion, como alicerces de uma interpretação da onda progressista que enfatiza as contradições inerentes à sua própria dinâmica que reforçou a razão neoliberal. A pretensão de governar as tensões sociais por meio de políticas de contenção do movimento dissocializante em curso não evitou a regressão da estrutura produtiva e o aprofundamento de uma dinâmica social autofágica. O progressismo revela-se como uma racionalidade política diferente, mas não contraditória em relação aos seus opositores em uma realidade em que o capital se impõe como uma força extra-parlamentar totalizante.