bluuebunny/crossref_metadata_2025_split huggingface dataset:
P2Y12 blocker monotherapy after percutaneous coronary intervention
Authors: Verheugt F. W. A. , Damman P. , Damen S. A. J. , Wykrzykowska J. J. , Woelders E. C. I. , van Geuns R. -J. M. 
Published: June 2021

AbstractFor secondary prevention of coronary artery disease (CAD) antiplatelet therapy is essential. For patients undergoing a percutaneous coronary intervention (PCI) temporary dual antiplatelet platelet therapy (DAPT: aspirin combined with a P2Y12 blocker) is mandatory, but leads to more bleeding than single antiplatelet therapy with aspirin. Therefore, to reduce bleeding after a PCI the duration of DAPT is usually kept as short as clinically acceptable; thereafter aspirin monotherapy is administered. Another option to reduce bleeding is to discontinue aspirin at the time of DAPT cessation and thereafter to administer P2Y12 blocker monotherapy. To date, five randomised trials have been published comparing DAPT with P2Y12 blocker monotherapy in 32,181 stented patients. Also two meta-analyses addressing this novel therapy have been presented. P2Y12 blocker monotherapy showed a 50–60% reduction in major bleeding when compared to DAPT without a significant increase in ischaemic outcomes, including stent thrombosis. This survey reviews the findings in the current literature concerning P2Y12 blocker monotherapy after PCI.
A domain decomposition method for the Navier–Stokes equations with stochastic input
Authors: Lu Junxiang , Su Jin 
Published: June 2021

AbstractThe paper is committed to studying the domain decomposition method for the incompressible Navier–Stokes equations(NSEs) with stochastic input. The stochastic input is represented spectrally by employing orthogonal polynomial functionals from the Askey scheme as trial basis to represent the random space, and the stochastic NSEs system are transformed into deterministic ones via the polynomial chaos expansion. The corresponding deterministic equations are transformed into the constrained optimization problem by minimizing the cost function on the common interface after the whole domain decomposed into two sub-domains. The constrained optimization problems are transformed into unconstrained problems by the Lagrange multiplier rule. A gradient method-based approach to the solutions of domain decomposition problem is proposed to solve the unconstrained optimality system. Finally, one numerical simulation experiment for square cavity flow problem with the stochastic boundary conditions are performed to demonstrate the feasibility and applicability of the gradient method.
Effect of the COVID-19 on Perceptions of Health, Anticipated Need for Health Services, and Cost of Health Care
Authors: Rekhter Natalia , Ermasova Natalia 
Published: June 2021

AbstractObjective:This article investigates how perceived vulnerability to the coronavirus disease 2019 (COVID-19) pandemic at its early stages is associated with people’s perception of their health, the need for health-care services, and expenses related to addressing the COVID-19 impact on their health.Methods:The results are based on the analysis of surveys that were distributed among members of 26 random Facebook groups in April-May, 2020. Perceived COVID-19 pandemic related stress and health concerns were examined by using the analysis of variance (ANOVA) test.Results:Among 315 respondents, 64% have experienced COVID-19 related stress and identified anxiety, headache, insomnia, and weight gain as their primary health concerns. The ANOVA test revealed that females are more impacted by the COVID-19 stress than males. Around 40% of respondents believed that the COVID-19 would lead to an increase in the cost of health services, and 20% of respondents anticipated that the COVID-19 pandemic would increase their need for health services.Conclusions:Learning about how people perceive the COVID-19 pandemic impact on their health, particularly in the pandemic’s early stages can allow health professionals to develop targeted interventions that can influence pandemic preventative behaviors among different population groups. This study can help understand use patterns and mitigate financial barriers that could interfere with patients’ care-seeking behavior.
The Southern California Extracorporeal Membrane Oxygenation Consortium During the Coronavirus Disease 2019 Pandemic
Authors: Odish Mazen , Yi Cassia , Eigner Juliann , Kenner Brininger Amelia , Koenig Kristi L. , Willms David , Lerum Suzan , McCaul Scott , Boyd King Ayana , Sutherland George , Cederquist Lynette , Owens Robert L. , Pollema Travis 
Published: June 2021

AbstractIn March 2020, at the onset of the coronavirus disease 2019 (COVID-19) pandemic in the United States, the Southern California Extracorporeal Membrane Oxygenation (ECMO) Consortium was formed. The consortium included physicians and coordinators from the 4 ECMO centers in San Diego County. Guidelines were created to ensure that ECMO was delivered equitably and in a resource effective manner across the county during the pandemic. A biomedical ethicist reviewed the guidelines to ensure ECMO use would provide maximal community benefit of this limited resource. The San Diego County Health and Human Services Agency further incorporated the guidelines into its plans for the allocation of scarce resources. The consortium held weekly video conferences to review countywide ECMO capacity (including census and staffing), share data, and discuss clinical practices and difficult cases. Equipment exchanges between ECMO centers maximized regional capacity. From March 1 to November 30, 2020, consortium participants placed 97 patients on ECMO. No eligible patients were denied ECMO due to lack of resources or capacity. The Southern California ECMO Consortium may serve as a model for other communities seeking to optimize ECMO resources during the current COVID-19 or future pandemics.
Stolen Skin and Children Thrown: Governing sex and abortion in early modern South Asia
Authors: CHERIAN DIVYA 
Published: June 2021

AbstractWhat did women's bodies in pre-colonial South Asia have to do with the birth of capitalism? South Asia's pre-colonial integration into a globally emerging, early modern capitalist order reached deep into the hinterland to transform both state and society in eighteenth-century Marwar. Driving the change was an emergent elite, consisting largely of merchants, that channelled its energies towards reshaping caste. Merchants, in alliance with Brahmans, used their influence upon the state to adjudicate the boundary between the ‘illicit’ and the ‘licit,’ generating in the process a typology and an archive of deviant sex. In the legal framework that generated this archive, women were configured as passive recipients of sexual acts, lacking sexual personhood in law. Even as they escaped legal culpability for ‘illicit’ sex, women experienced, through this body of judgments, a strengthening of male proprietary controls over their bodies. Alongside, the criminalization of abortion served as a means of sexual disciplining. These findings suggest that post-Mughal, pre-colonial state formation in South Asia intersected with global economic transformations to generate new sex-caste orders and archival bodies.
Anatolian-Persian grave stelae from Bozüyük in Phrygia: a contribution to understanding Persian presence and organisation in the region
Authors: Erpehlivan Hüseyin 
Published: June 2021

AbstractThis paper provides an assessment of four grave stelae that were found recently in the area surrounding Bozüyük, on the Anatolian plateau in the south of the Bilecik province. The plateau was part of the core of the kingdom of Phrygia during the Early and Middle Iron Ages, and part of the satrapy of Phrygia during the Achaemenid period of the Late Iron Age in Anatolia. The main focus is to examine the place of such stelae among Anatolian-Persian examples and to explore elements of Persian presence and organisation in the region. The precise archaeological contexts of these stelae are unknown, but are likely to have been tumuli. They are examples of an Anatolian-Persian style from the Achaemenid period, but can also be considered to be part of a somewhat rustic 'rural' sub-style, compared with more elaborate stelae that have been found around Dascylium, the satrapal capital of Hellespontine Phrygia. The Bozüyük stelae feature banquet, hunting and ritual scenes, and also battle scenes that distinguish them from other Anatolian-Persian stelae. Despite similarities, particularly with the Vezirhan stele, there are also discrepancies that make precise analogies with reliefs on other stelae difficult, though not impossible. It is likely that they were created by a connected group of sculptors, and might therefore be evidence of a workshop that sculpted local materials in a unique rural style.
The rock inscriptions, graffiti and crosses from Quarry GO3C at Göktepe, Muğla district (Turkey)
Authors: Nowakowski Paweł , Wielgosz-Rondolino Dagmara 
Published: June 2021

AbstractThis paper discusses some of the results of a geo-archaeological survey conducted in 2014 in the marble quarries at Göktepe near Muğla (the ancient region of Caria). During the survey we examined a dossier of both already known and newly recorded rock inscriptions and textual and pictorial graffiti (prominently including crosses) from District 3, Quarry C (= Quarry GO3C). Here, we aim to explore the contents and spatial contexts of these texts and images, and consider them in relation to the pottery finds and literary sources, in order to throw new light on the history of the quarry. The texts and images suggest that at some point the site was abandoned as a quarry and, probably already in late antiquity, resettled by hermits.
AGE/RAGE/DIAPH1 axis is associated with immunometabolic markers and risk of insulin resistance in subcutaneous but not omental adipose tissue in human obesity
Authors: Ruiz Henry H. , Nguyen Anh , Wang Chan , He Linchen , Li Huilin , Hallowell Peter , McNamara Coleen , Schmidt Ann Marie 
Published: June 2021

AbstractBackground/objectivesThe incidence of obesity continues to increase worldwide and while the underlying pathogenesis remains largely unknown, nutrient excess, manifested by “Westernization” of the diet and reduced physical activity have been proposed as key contributing factors. Western-style diets, in addition to higher caloric load, are characterized by excess of advanced glycation end products (AGEs), which have been linked to the pathophysiology of obesity and related cardiometabolic disorders. AGEs can be “trapped” in adipose tissue, even in the absence of diabetes, in part due to higher expression of the receptor for AGEs (RAGE) and/or decreased detoxification by the endogenous glyoxalase (GLO) system, where they may promote insulin resistance. It is unknown whether the expression levels of genes linked to the RAGE axis, includingAGER(the gene encoding RAGE), Diaphanous 1 (DIAPH1), the cytoplasmic domain binding partner of RAGE that contributes to RAGE signaling, andGLO1are differentially regulated by the degree of obesity and/or how these relate to inflammatory and adipocyte markers and their metabolic consequences.Subjects/methodsWe sought to answer this question by analyzing gene expression patterns of markers of the AGE/RAGE/DIAPH1 signaling axis in abdominal subcutaneous (SAT) and omental (OAT) adipose tissue from obese and morbidly obese subjects.ResultsIn SAT, but not OAT, expression ofAGERwas significantly correlated with that ofDIAPH1(n = 16;$$\hat \beta = 0.719$$β̂=0.719, [0.260, 1.177];q = 0.008) andGLO1(n = 16;$$\hat \beta = 0.773$$β̂=0.773, [0.364, 1.182];q = 0.004). Furthermore, in SAT, but not OAT, regression analyses revealed that the expression pattern of genes in the AGE/RAGE/DIAPH1 axis is strongly and positively associated with that of inflammatory and adipogenic markers. Remarkably, particularly in SAT, not OAT, the expression ofAGERpositively and significantly correlated with HOMA-IR (n = 14;$$\hat \beta = 0.794$$β̂=0.794, [0.338, 1.249];q = 0.018).ConclusionsThese observations suggest associations of the AGE/RAGE/DIAPH1 axis in the immunometabolic pathophysiology of obesity and insulin resistance, driven, at least in part, through expression and activity of this axis in SAT.
A new discovery of STAT4 single nucleotide polymorphisms associated with hepatocellular carcinoma risk in Chinese Han population: a case–control study
Authors: Chao Xu , Wu Jieqiong , Zhang Wei , Feng Xuesong , Zhao Luyan , Huang Feng , Jiang Chao 
Published: June 2021

Abstract
Background: Hepatocellular carcinoma (HCC) is a common fatal malignant tumor worldwide. Signal transducer and activator of transcription 4 (STAT4) is HCC susceptibility gene identified by genome-wide association study. The purpose of the present study was to determine the association between four candidate single nucleotide polymorphisms (SNPs) in STAT4 genes and HCC risk in Chinese Han population.
Methods: A case–control study was conducted to assess the association between STAT4 SNPs and HCC risk in 1011 Chinese Han population. Agena MassARRAY was used to genotype SNPs. The association between SNPs and HCC susceptibility under different genetic models was evaluated by logistic regression analysis. Multifactorial dimension reduction (MDR) analyzed the interaction of ‘SNP–SNP’ in HCC risk. The difference of clinical characteristics between different genotypes was completed by ANOVA.
Results: The results showed that STAT4 rs11889341 was significantly associated with HCC risk under multiple genetic models (homozygote: odds ratio (OR) = 0.60, P=0.033; recessive: OR = 0.63, P=0.028; log-additive: OR = 0.83, P=0.032). The results of subgroup analysis showed that STAT4 rs11889341 is significantly associated with HCC risk with participants who were &gt;55 years, male or smoking. Both STAT4 rs7574865 and rs10174238 were significantly associated with HCC risk among participants who were &gt;55 years, smoking or drinking. STAT4 haplotype (Trs11889341Trs7574865) could reduce the risk of HCC. In addition, rs11889341 and rs7574865 were significantly associated with the level of serum ferritin (SF).
Conclusion: STAT4 rs11889341, rs7574865 or rs10174238 is potentially associated with HCC risk in Chinese Han population. In particular, rs11889341 showed outstanding association with HCC risk.
Revision Rhinoplasty: With Introduction of a Novel Preoperative Assessment Classification System
Authors: Jiang Austin , Chamata Edward S. , Bressler Fred J. 
Published: June 2021

AbstractRevision rhinoplasty presents several complex surgical challenges. Proper patient selection for revision rhinoplasty, along with thorough preoperative examination and surgical planning, is key to achieving ideal outcomes. Along with achieving a high level of understanding of primary rhinoplasty techniques, surgeons performing revision rhinoplasty must understand and diagnose deformities created by the primary surgery. A systematic approach to diagnosing rhinoplasty deformities assists in forming a suitable surgical plan. A classification system based on nasal analysis, described here, may be used to differentiate the degree of difficulty of the surgery as well as assist in surgical planning. Surgeons have a multitude of options available in their armamentarium for addressing common nasal deformities encountered during revisional surgery, and a stepwise surgical approach may facilitate the creation of an optimal aesthetic and functional result.
Language extinction triggers the loss of unique medicinal knowledge
Authors: Cámara-Leret Rodrigo , Bascompte Jordi 
Published: June 2021

SignificanceThe United Nations proclamation of 2022–2032 as the International Decade of Indigenous Languages aims to raise global awareness about their endangerment and importance for sustainable development. Indigenous languages contain the knowledge that communities have about their surrounding plants and the services they provide. The use of plants in medicine is a particularly relevant example of such ecosystem services. Here, we find that most medicinal knowledge is linguistically unique—i.e., known by a single language—and more strongly associated with threatened languages than with threatened plants. Each indigenous language is therefore a unique reservoir of medicinal knowledge—a Rosetta stone for unraveling and conserving nature’s contributions to people.
Effect of recycled course aggregate from concrete debris on the strength of concrete
Authors: Lesovik V S , Lesovik R V , Albo Ali W S 
Published: June 2021

Abstract
The paper investigates the fresh and hardened mechanical properties of a concrete mix produced with partial or full substitution of natural aggregates with recycled aggregates from demolition works and crushed tested cubes concrete from laboratory. Recycled aggregate concrete (RAC) is the concrete that has been made from waste materials recycled as coarse and/or fine aggregate. One of the waste materials is the concrete that is taken from demolished buildings in Iraq due to military operations on 2014 and the other is crushed tested concrete cubes from laboratory. Choosing crushed concrete wastes from demolition works and crushed test cubes concrete from laboratory as source of recycling would result in reusing portion of the waste products of the concrete production industry. This study presents an experimental study on the performance of concrete that contains recycled coarse aggregate. The replacement percentages of natural coarse aggregate with the recycled coarse aggregate are (0, 33.3, 66.7 and 100) %. Moreover, silica fume was used as an admixture for all recycled aggregate concretes. Compressive and indirect tensile strength were studied for all of the reference and recycled aggregate concretes at (28) days age, by testing concrete cubes and cylinders specimens respectively. The results showed that the compressive strength and splitting tensile strength decreased for recycled waste concretes taken from demolished buildings and increased for recycled crushed tested cubes concretes from laboratory as compared to the reference concrete. When the silica fume was added, the compressive strength and tensile strength increased for all recycled aggregate concretes compared to those without the silica fume.
Method for controlling reaction mass parameters during the synthesis of alkyd resins
Authors: Dubovik N S , Matyas D S , Dubovik S A , Lyubushkin R A 
Published: June 2021

Abstract
Synthesis of alkyd resins is one of the most common technological processes for deep processing of vegetable oils. In Russia, about 700 thousand tons of alkyd resins are produced per year; so much attention is paid to improving the production process of alkyd resins. Production of synthesis of alkyd resins can be classified as fire and explosive hazardous. One of the main reasons for the high level of accidents in the synthesis of alkyd lacquers and resins is the lack of digitalization of control and management of synthesis. This paper discusses the possibility of using changes in the electrical properties of the reaction mass to control the flow of a chemical synthesis reaction. The principal difference between the proposed approach is that it is proposed to use measurements of DC values directly in the technological process. Studies have shown that it is more promising to use the analysis of the values of the complex resistance module of the reaction mass for the purposes of synthesis control. The advantage of this solution is that the method is more informative, as observations are made in a two-dimensional space of complex values rather than in a one-dimensional one. When using high-frequency alternating current, the module and phase of the complex resistance of the reaction mass are controlled, as well as a number of other parameters (leakage current, q-factor, etc.)
Promising methods of ice control of air heat pump evaporators
Authors: Orlov P A , Il`ina T N , Orlov K P 
Published: June 2021

Abstract
Heat pumps are used as alternative equipment in the arrangement of hot water treatment and heating of buildings and premises. The principle of the device and functioning of heat pumps, the processes that take place during the removal of low-potential heat are described. The features of the operation of air heat pumps at subzero temperatures are disclosed. The reasons for the low transformation coefficient of air heat pumps at negative outdoor temperature are considered. This paper describes the main existing methods for ice control of heat exchangers of air heat pumps: the method of the reverse of the refrigerant, bypass method, method of ice control with non-freezing solutions, accumulative method, method of thawing using the electrical warming up evaporator, defrosting with the help of the air flow, their advantages and disadvantages in the process at low temperatures. A promising method for removing ice from heat exchangers using mechanical vibrations is presented. The operating parameters of air heat pumps with different thawing methods are given. It examines their effectiveness when the air temperature is -25°C, a comparison of energy consumption for ice control of the outdoor unit of heat exchanger of air heat pump, presents photos of the process of removing ice from the air evaporator of heat exchanger.
Local exhaust ventilation with reduced energy consumption during bulk materials overloads into receiving cones of coarse crushing plants
Authors: Averkova O A , Golyshev A A , Logachev K I , Uvarov V A 
Published: June 2021

Abstract
An intense dust emissions occur when bulk materials are unloaded by wagons into receiving cones of coarse crushing bodies (CCB). The most reliable, but energy-intensive way to localize dust emissions is the use of local exhaust ventilation systems. For the correct calculation of the performance of the exhaust ventilation system, it is necessary to determine the flow rate of air entrained in bulk material (flow rate of ejected air), which is the main source of dust emission distribution. The volume of air carried away by bulk material is determined based on the use of the classical theory of mechanics of two -component flows. Using the methods of boundary integral equations, a mathematical motion of the air flow in the cavity of the receiving cone of the CCB has been developed. A laboratory model of the CCB receiving cone was created, where the air flow carried away by the bulk material was modelled using a smoky jet flowing out of the supply nozzle. Based on the conducted computational and field experiments, the location of the local ventilation suction and mechanical screens are selected to increase the efficiency of local exhaust ventilation and reduce the energy consumption of the aspiration system.