bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soot Volume Fraction Measurements by Auto-Compensating Laser-Induced Incandescence in Diffusion Flames Generated by Ethylene Pool Fire
Authors: Cruz Juan J. , Verdugo Ignacio , Gutiérrez-Cáceres Nicolás , Escudero Felipe , Demarco Rodrigo , Liu Fengshan , Yon Jérôme , Chen Dongping , Fuentes Andrés 
Published: November 2021

The main characteristics of pool fire flames are flame height, air entrainment, pulsation of the flame, formation and properties of soot particles, mass burning rate, radiation feedback to the pool surface, and the amount of pollutants including soot released to the environment. In this type of buoyancy controlled flames, the soot content produced and their subsequent thermal radiation feedback to the pool surface are key to determine the self-sustainability of the flame, their mass burning rate and the heat release rate. The accurate characterization of these flames is an involved task, specially for modelers due to the difficulty of imposing adequate boundary conditions. For this reason, efforts are being made to design experimental campaigns with well-controlled conditions for their reliable repeatability, reproducibility and replicability. In this work, we characterized the production of soot in a surrogate pool fire. This is emulated by a bench-scale porous burner fueled with pure ethylene burning in still air. The flame stability was characterized with high temporal and spatial resolution by using a CMOS camera and a fast photodiode. The results show that the flame exhibit a time-varying propagation behavior with a periodic separation of the reactive zone. Soot volume fraction distributions were measured at nine locations along the flame centerline from 20 to 100 mm above the burner exit using the auto-compensating laser-induced incandescence (AC-LII) technique. The mean, standard deviation and probability density function of soot volume fraction were determined. Soot volume fraction presents an increasing tendency with the height above the burner, in spite of a local decrease at 90 mm which is approximately the position separating the lower and attached portion of the flame from the higher more intermittent one. The results of this work provide a valuable data set for validating soot production models in pool fire configurations.
Increased Levels of sCD30 Have No Impact on the Incidence of Early ABMR and Long-Term Outcome in Intermediate-Risk Renal Transplant Patients With Preformed DSA
Authors: Drasch Thomas , Bach Christian , Luber Markus , Spriewald Bernd , Utpatel Kirsten , Büttner-Herold Maike , Banas Bernhard , Zecher Daniel 
Published: November 2021

Background: It is still incompletely understood why some patients with preformed donor-specific anti-HLA antibodies (DSA) have reduced kidney allograft survival secondary to antibody-mediated rejection (ABMR), whereas many DSA-positive patients have favorable long-term outcomes. Elevated levels of soluble CD30 (sCD30) have emerged as a promising biomarker indicating deleterious T-cell help in conjunction with DSA in immunologically high-risk patients. We hypothesized that this would also be true in intermediate-risk patients.Methods: We retrospectively analyzed pre-transplant sera from 287 CDC-crossmatch negative patients treated with basiliximab induction and tacrolimus-based maintenance therapy for the presence of DSA and sCD30. The incidence of ABMR according to the Banff 2019 classification and death-censored allograft survival were determined.Results: During a median follow-up of 7.4 years, allograft survival was significantly lower in DSA-positive as compared to DSA-negative patients (p &lt; 0.001). In DSA-positive patients, most pronounced in those with strong DSA (MFI &gt; 5,000), increased levels of sCD30 were associated with accelerated graft loss compared to patients with low sCD30 (3-year allograft survival 75 vs. 95%). Long-term survival, however, was comparable in DSA-positive patients irrespective of sCD30 status. Likewise, the incidence of early ABMR and lesion score characteristics were comparable between sCD30-positive and sCD30-negative patients with DSA. Finally, increased sCD30 levels were not predictive for early persistence of DSA.Conclusion: Preformed DSA are associated with an increased risk for ABMR and long-term graft loss independent of sCD30 levels in intermediate-risk kidney transplant patients.
A Pediatric Sepsis Protocol Reduced Mortality and Dysfunctions in a Brazilian Public Hospital
Authors: Medeiros Daniela Nasu Monteiro , Mafra Ana Carolina Cintra Nunes , Carcillo Joseph Anthony , Troster Eduardo Juan 
Published: November 2021

Introduction:Few studies in the literature discuss the benefits of compliance with sepsis bundles in hospitals in low- and middle-income countries, where resources are limited and mortality is high.Methods:This is a retrospective cohort study conducted at a public hospital in a low-income region in Brazil. We evaluated whether completion of a sepsis bundle is associated with reduced in-hospital mortality for sepsis, severe sepsis, and septic shock, as well as prevention of septic shock and organ dysfunction. Bundle compliance required the completion of three items: (1) obtaining blood count and culture, arterial or venous blood gases, and arterial or venous lactate levels; (2) antibiotic infusion within the first hour of diagnosis; and (3) infusion of 10–20 ml/kg saline solution within the first hour of diagnosis.Results:A total of 548 children with sepsis, severe sepsis, or septic shock who were treated at the emergency room from February 2008 to August of 2016 were included in the study. Of those, 371 patients were included in the protocol group and had a lower median length of stay (3 days vs. 11 days;p&lt; 0.001), fewer organ dysfunctions during hospitalization (0 vs. 2,p&lt; 0.001), and a lower probability of developing septic shock. According to a propensity score analysis, mortality was lower during the post-implementation period [2.75 vs. 15.4% (RR 95%IC 0.13 (0.06, 0.27);p&lt; 0.001)].Conclusions:A simple and low-cost protocol was feasible and yielded good results at a general hospital in a low-income region in Brazil. Protocol use resulted in decreased mortality and progression of dysfunctions and was associated with a reduced probability of developing septic shock.
Intermittent Bi-Daily Sub-cutaneous Teriparatide Administration in Children With Hypoparathyroidism: A Single-Center Experience
Authors: Bernardor Julie , Flammier Sacha , Cabet Sara , Lemoine Sandrine , Chapurlat Roland , Molin Arnaud , Bertholet-Thomas Aurélia , Bacchetta Justine 
Published: November 2021

Introduction: The use of teriparatide has been reported in children with hypoparathyroidism as an investigational physiologic replacement therapy.Methods: We aimed to retrospectively report our pediatric experience of bi-daily sub-cutaneous teriparatide. Results are presented as median (25th−75th quartile). As part of the routine follow-up of these patients with hypoparathyroidism, total calcium at H0 (i.e., just before injection) and H4 (i.e., 4 h after teriparatide injection) and other biomarker parameters were regularly assessed.Results: At a median age of 10.7 (8.1–12.6) years, an estimated glomerular filtration rate (eGFR) of 110 (95–118) mL/min/1.73 m2, calcium levels of 1.87 (1.81–1.96) mmol/L and an age-standardized phosphate of 3.8 (2.5–4.9) SDS, teriparatide therapy was introduced in 10 patients at the dose of 1.1 (0.7–1.5) μg/kg/day (20 μg twice daily), with further adjustment depending on calcium levels. Six patients already displayed nephrocalcinosis. Severe side effects were reported in one child: two episodes of symptomatic hypocalcemia and one of iatrogenic hypercalcemia; one teenager displayed dysgueusia. Calcium levels at H0 did not significantly increase whilst calcium at H4 and phosphate levels significantly increased and decreased, respectively. After 12 months, eGFR, calcium and age-standardized phosphate levels were 108 (90–122) mL/min/1.73 m2, 2.36 (2.23–2.48) mmol/L, 0.5 (−0.1 to 1.5), and 68 (63–74) nmol/L, respectively, with a significant decrease in phosphate levels (p = 0.01). Urinary calcium and calcium/creatinine ratio remained stable; no nephrolithiasis was observed but two moderate nephrocalcinosis appeared.Conclusion: Intermittent teriparatide therapy significantly improves calcium and phosphate control, without increasing calciuria. It appears to be safe and well-tolerated in children.
Exploring the Experience of Healthcare Workers Who Returned to Work After Recovering From COVID-19: A Qualitative Study
Authors: Zhang Hui , Chen Dandan , Zou Ping , Cui Nianqi , Shao Jing , Qiu Ruoling , Wang Xiyi , Wu Man , Zhao Yi 
Published: November 2021

Background: To date, a large body of literature focuses on the experience of healthcare providers who cared for COVID-19 patients. Qualitative studies exploring the experience of healthcare workers in the workplace after recovering from COVID-19 are limited. This study aimed to describe the experience of healthcare workers who returned to work after recovering from COVID-19.Methods: This study employed a qualitative descriptive approach with a constructionist epistemology. Data were collected through semi-structured in-depth interviews with 20 nurses and physicians, and thematic analysis was used to identify themes from the interview transcripts.Results: Three major themes about the psychological experiences of healthcare workers who had recovered from COVID-19 and returned to work were identified: (1) holding multi-faceted attitudes toward the career (sub-themes: increased professional identity, changing relationships between nurses, patients, and physicians, and drawing new boundaries between work and family), (2) struggling at work (sub-themes: poor interpersonal relationships due to COVID-19 stigma, emotional symptom burden, physical symptom burden, and workplace accommodations), (3) striving to return to normality (sub-themes: deliberate detachment, different forms of social support in the workplace, and long-term care from organizations).Conclusions: The findings have highlighted opportunities and the necessity to promote health for this population. Programs centered around support, care, and stress management should be developed by policymakers and organizations. By doing this, healthcare workers would be better equipped to face ongoing crises as COVID-19 continues.
Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice
Authors: Zwetsloot Kevin A. , Shanely R. Andrew , Godwin Joshua S. , Hodgman Charles F. 
Published: November 2021

Background: Eccentric muscle contractions are commonly used in exercise regimens, as well as in rehabilitation as a treatment against muscle atrophy and weakness. If repeated multiple times, eccentric contractions may result in skeletal muscle injury and loss of function. Skeletal muscle possesses the remarkable ability to repair and regenerate after an injury or damage; however, this ability is impaired with aging. Phytoecdysteroids are natural plant steroids that possess medicinal, pharmacological, and biological properties, with no adverse side effects in mammals. Previous research has demonstrated that administration of phytoecdysteroids, such as 20-hydroxyecdysone (20E), leads to an increase in protein synthesis signaling and skeletal muscle strength.Methods: To investigate whether 20E enhances skeletal muscle recovery from eccentric contraction-induced damage, adult (7–8 mo) and old (26–27 mo) mice were subjected to injurious eccentric contractions (EC), followed by 20E or placebo (PLA) supplementation for 7 days. Contractile function via torque-frequency relationships (TF) was measured three times in each mouse: pre- and post-EC, as well as after the 7-day recovery period. Mice were anesthetized with isoflurane and then electrically-stimulated isometric contractions were performed to obtain in vivo muscle function of the anterior crural muscle group before injury (pre), followed by 150 EC, and then again post-injury (post). Following recovery from anesthesia, mice received either 20E (50 mg•kg−1 BW) or PLA by oral gavage. Mice were gavaged daily for 6 days and on day 7, the TF relationship was reassessed (7-day).Results: EC resulted in significant reductions of muscle function post-injury, regardless of age or treatment condition (p &lt; 0.001). 20E supplementation completely recovered muscle function after 7 days in both adult and old mice (pre vs. 7-day; p &gt; 0.05), while PLA muscle function remained reduced (pre vs. 7-day; p &lt; 0.01). In addition, histological markers of muscle damage appear lower in damaged muscle from 20E-treated mice after the 7-day recovery period, compared to PLA.Conclusions: Taken together, these findings demonstrate that 20E fully recovers skeletal muscle function in both adult and old mice just 7 days after eccentric contraction-induced damage. However, the underlying mechanics by which 20E contributes to the accelerated recovery from muscle damage warrant further investigation.
The GoodHope Exercise and Rehabilitation (GEAR) Program for People With Ehlers-Danlos Syndromes and Generalized Hypermobility Spectrum Disorders
Authors: Mittal Nimish , Santa Mina Daniel , Buryk-Iggers Stephanie , Lopez-Hernandez Laura , Hussey Laura , Franzese Alyssa , Katz Joel , Laflamme Camille , McGillis Laura , McLean Lianne , Rachinsky Maxim , Rozenberg Dmitry , Slepian Maxwell , Weinrib Aliza , Clarke Hance 
Published: November 2021

Introduction: The Ehlers-Danlos Syndromes (EDS) and Generalized Hypermobility Spectrum Disorders (G-HSD) comprise a heterogeneous group of genetic disorders of abnormal synthesis and/or maturation of collagen and other matricellular proteins. EDS is commonly characterized by manifestations such as multi joint hypermobility that can lead to musculoskeletal pains, subluxations and dislocations, fragile skin, organ dysfunction, and chronic significant diffuse pain with fatigue, deconditioning eventuating to poor quality of life. Evidence suggests exercise and rehabilitation interventions may ameliorate symptoms of unstable joints, recurrent subluxations/dislocations, and chronic widespread musculoskeletal pain. To date, there have only been a few reports describing exercise and rehabilitation care strategies for people with EDS.Methods: In this manuscript, we describe the GoodHope Exercise and Rehabilitation (GEAR) program, its overarching principles, as well as the program development and delivery model. The GEAR program aims to decrease functional impairment, reduce pain, increase confidence in symptom self-management, and provide a community of support for people with EDS/G-HSD. To achieve these goals, we detail the model of care that includes exercise and rehabilitation therapy, education for self-management, and support accessing relevant community resources.Strengths and Limitations of the Study: GEAR represents a novel exercise and rehabilitation care model for people with G-HSD and various clinical EDS subtypes, beyond the commonly included hEDS subtype. Systematic collection of data via validated measurements is ongoing and will guide the refinement of GEAR and support the development of emerging exercise and rehabilitation programs for people with EDS.
Analysis of Ionizing Radiation Induced DNA Damage by Superresolution dSTORM Microscopy
Authors: Brunner Szilvia , Varga Dániel , Bozó Renáta , Polanek Róbert , Tőkés Tünde , Szabó Emília Rita , Molnár Réka , Gémes Nikolett , Szebeni Gábor J. , Puskás László G. , Erdélyi Miklós , Hideghéty Katalin 
Published: November 2021

The quantitative detection of radiation caused DNA double-strand breaks (DSB) by immunostained γ-H2AX foci using direct stochastic optical reconstruction microscopy (dSTORM) provides a deeper insight into the DNA repair process at nanoscale in a time-dependent manner. Glioblastoma (U251) cells were irradiated with 250 keV X-ray at 0, 2, 5, 8 Gy dose levels. Cell cycle phase distribution and apoptosis of U251 cells upon irradiation was assayed by flow cytometry. We studied the density, topology and volume of the γ-H2AX foci with 3D confocal microscopy and the dSTORM superresolution method. A pronounced increase in γ-H2AX foci and cluster density was detected by 3D confocal microscopy after 2 Gy, at 30 min postirradiation, but both returned to the control level at 24 h. Meanwhile, at 24 h a considerable amount of residual foci could be measured from 5 Gy, which returned to the normal level 48 h later. The dSTORM based γ-H2AX analysis revealed that the micron-sized γ-H2AX foci are composed of distinct smaller units with a few tens of nanometers. The density of these clusters, the epitope number and the dynamics of γ-H2AX foci loss could be analyzed. Our findings suggest a discrete level of repair enzyme capacity and the restart of the repair process for the residual DSBs, even beyond 24 h. The dSTORM superresolution technique provides a higher precision over 3D confocal microscopy to study radiation induced γ-H2AX foci and molecular rearrangements during the repair process, opening a novel perspective for radiation research.
HUBUNGAN PENGGUNAAN BETADINE SALEP TERHADAP KEJADIAN FLEBITIS PADA TEMPAT PEMASANGAN INFUS INTRAVENA DI RUMAH SAKIT TENTARA TINGKAT IV 01.07.01 PEMATANGSIANTAR TAHUN 2021
Authors: Sitepu Kuat , Purba Anita Srigandaria , Sara Arfah May , . Widya 
Published: November 2021

Background : The incidence of ebitis is one indicator of the quality of hospital services with the standard set by The Infusion Nursing of Practice, which is 5%. The incidence of phlebitis is an indicator of minimum hospital service quality with a standard incidence of â‰¤1.5%. Purpose : Knowing the effect of using betadine ointment on the incidence of phlebitis at the intravenous infusion site at the Army Hospital TK IV. 01.07.01 Pematangsiantar. Methods : This type of research the researcher used was a quasi experiment with the equivalent control group design. The research instrument used was an observation sheet with a sample of 30 patients who had an intravenous infusion attached. Results: There was a significant effect of using betadine ointment on the incidence of phlebitis on intravenous infusion therapy. Statistical analysis using normality test, homogeneity and hypothesis testing. Conclusions and suggestions : The use of betadine ointment against the incidence of phlebitis at the intravenous infusion site has a significant relationship. Therefore the hospital management must continue to make efforts to improve services to patients. As a suggestion, room nurses should increase their knowledge through training on infection control and prevention, nosocomial infection prevention training in hospitals.
DURASI PENGGUNAAN GADGET TERHADAP NYERI LEHER PADA MAHASISWA DI MASA PANDEMI COVID-19
Authors: Hikmah Nurhikmah , Puspitasari Nurwahida 
Published: November 2021

The COVID-19 pandemic has an impact on the world of education. Thus, colleges or universities take alternative learning that is carried out online or commonly reffered to as study from home. This policy greatly affects the use of gadgets for university students because the learning process, which is deal with gadgets every day and will take longer time than usual. This can trigger musculoskeletal disorders, one of which is neck pain. The purpose of this study was to determine the relationship between the duration of gadget use on neck pain in university student during the COVID-19 pandemic. This research method an analytical observational with cross sectional time approach. Respondents in this study were physiotherapy students with a total population of 695 students with inclusion criteria is students aged 18-25 years. The sample in this study was taken by purposive sampling technique and the sample size was determined by the Slovin formula, totaling 88 students. The duration of gadget use was measured by category and neck pain was measured using the neck disability index. The data were analyzed using the Spearman Rank test of the duration of gadget use and neck pain complaints were p=0.588 (p>0.05) with (CC=0.059). The conclusion is that the long duration of using gadget cannot increase the occurrence of neck pain in university students during the COVID-19 pandemic and the correlation is very weak.
PENGEMBANGAN SISTEM UJIAN ONLINE MINAT DAN BAKAT SISWA SMK PADA SMK ISLAM BATU
Authors: Amarta Sholehuddin Mohamma Dandy , Auliasari Karina , Faisol Ahmad 
Published: November 2021

Banyaknya penerimaan siswa baru pada smk islam batu maka dengan adanya sistem ini dapat membantu dan memilah siswa baru yang akan masuk ke smk islam batu melalui ujian minat dan bakat yang dimana pada sistem ujian minat dan bakat untuk mengetahui dimana jurusan yang tepat untuk di masuki oleh calon siswa smk islam batu.
Oleh Sebab itu penulis membuat sistem ujian online minat dan bakat untuk memudahnkan proses penerimaan siswa baru dan pembagian jurusan yang tepat bagi calon siswa smk islam batu yang akan di masukinya nanti dan sistem ujian online minat dan bakat ini berbasis web yang di mana calon siswa dapat mengakses ujian minat dan bakat tersebut.
ANALISIS PERBANDINGAN METODE SINGLE EXPONENTIAL SMOOTHING DAN TREND PARABOLIK UNTUK PREDIKSI PENJUALAN KOPI (STUDI KASUS PADA TODAY COFFEE)
Authors: Bastomi Dwi , Auliasari Karina , Zulfia Zahro’ Hani 
Published: November 2021

Didalam dunia bisnis dan usaha mengharuskan perusahan untuk merancang berbagai macam strategi usaha untuk dapat bertahan. Peramalan atau prediksi inilah yang digunakan sebagai salah satu bahan pertimbangan terutama dalam sektor bisnis dan ekonomi, dimana kerugian suatu perusahaan dapat diminimalisir sebisa mungkin dan keuntungan dapat diraih semaksimal mungkin. Maka dari itu diperlukan suatu perhitungan untuk memprediksi setiap periodenya. Dalam hal ini diterapkan analisis perhitungan metode trend parabolic dan single exponential smoothing dengan nilai alpha 0,1, 0,3, 0,5, 0,7 dan 0,9.
Untuk menghitung prediksi penjualan kopi today coffee yang berada di Tulungagung. Kedua metode tersebut dibandingkan untuk mendapatkan nilai akurasi tertinggi (nilai kesalahan terkecil) dengan menggunakan perhitungan MAPE. Data yang digunakan sebagai prediksi adalah data penjualan kopi pada bulan juli 2020 sampai bulan maret 2021. Setelah dilakukan perhitungan didapatkan hasil prediksi menggunakan metode trend parabolic dengan nilai rata-rata MAPE di semua varian rasa sebesar 37,23% dan pada metode single exponential smoothing mendapatkan nilai rata-rata MAPE di semua varian rasa sebesar 54,37%.