bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co-dependency of exchanged behaviors is a cue for agency attribution in 10-month-olds
Authors: Tauzin Tibor , Gergely György 
Published: September 2021

AbstractGoal-directed social interactions (whether instrumental or communicative) involve co-dependent, partially predictable actions of interacting agents as social goals cannot be achieved by continuously exchanging the same, perfectly predictable, or completely random behaviors. We investigated whether 10-month-olds are sensitive to the co-dependence and degree of predictability in an interactive context where unfamiliar entities exchanged either perfectly predictable (identical), partially predictable (co-dependent), or non-predictable (random) signal sequences. We found that when—following the interactive exchanges—one of the entities turned in the direction of one of two lateral target objects, infants looked more at the indicated referent, but only in the partially predictable signals condition. This shows that infants attributed agency to the orienting entity and interpreted its turning action as a referential object-directed action. The present findings suggest that the co-dependency and partial predictability of exchanged behaviors can serve as an abstract structural cue to attribute intentional agency and recognize goal-directed social interactions.
Polyoxometalate@MOF derived porous carbon-supported MoO2/MoS2 octahedra boosting high-rate lithium storage
Authors: Yu Jian , Wang Ming-Liang , Yang Zhong-Xi , Li Kui , Yang Xiao-Peng , Gao Guang-Gang , Yin Di , Fan Lin-Lin , Liu Hong 
Published: September 2021

C-MoO2/MoS2 octahedral heterostructure is fabricated from NENU-5, in which the ordered dispersion and encapsulation of POM at the molecular level can be achieved. The high capacitive contribution results in the fast lithiation/delithiation processes.
Factors Explaining Deficits in Reading Acquisition: The Case of Williams Syndrome
Authors: Pezzino Anne-Sophie , Marec-Breton Nathalie , Gonthier Corentin , Lacroix Agnès 
Published: September 2021

PurposeMultiple factors impact reading acquisition in individuals with reading disability, including genetic disorders such as Williams syndrome (WS). Despite a relative strength in oral language, individuals with WS usually have an intellectual disability and tend to display deficits in areas associated with reading. There is substantial variability in their reading skills. While some authors have postulated that phonological deficits are at the source of their reading deficits, others have suggested that they can be attributed to visuospatial deficits. This study was the first to undertake an in-depth exploration of reading skills among French-speaking children and adults with WS. We tested the assumption that some factors influence performance on single-word identification among individuals with WS, with a focus on the roles of phonological awareness and visuospatial skills.MethodParticipants were 29 French-speaking adults with WS and 192 controls matched for nonverbal mental age and reading level. We administered tests assessing reading (decoding and word recognition), vocabulary (expressive and receptive), and phonological and visuospatial skills. We also controlled for chronological age and nonverbal reasoning.ResultsPhonemic awareness was the most predictive factor of single-word identification in the WS group. Visuospatial skills also contributed, but not more or beyond other factors. More broadly, reasoning skills may also have accounted for the variability in single-word identification in WS, but this was not the case for either chronological age or vocabulary.ConclusionsThere is considerable heterogeneity among adults with WS, who may be either readers or prereaders. Similar profiles identified among individuals with other specific learning disabilities suggest that high reading variability is not specific to the neuropsychological profile of WS. We discuss a multidimensional approach to the factors involved in reading deficits in WS.
The Anti-Proliferative Lichen-Compound Protolichesterinic Acid Inhibits Oxidative Phosphorylation and Is Processed via the Mercapturic Pathway in Cancer Cells
Authors: Jóhannsson Freyr , Cherek Paulina , Xu Maonian , Rolfsson Óttar , Ögmundsdóttir Helga M. 
Published: September 2021

AbstractThe lichen compound protolichesterinic acid (PA) has an anti-proliferative effect against several cancer cell lines of different origin. This effect cannot be explained by the known inhibitory activity of PA against 5- and 12-lipoxygenases. The aim was therefore to search for mechanisms for the anti-proliferative activity of PA. Two cancer cell lines of different origin, both sensitive to anti-proliferative effects of PA, were selected for this study, T-47D from breast cancer and AsPC-1 from pancreatic cancer. Morphological changes were assessed by transmission electron microscopy, HPLC coupled with TOF spectrometry was used for metabolomics, mitochondrial function was measured using the Agilent Seahorse XFp Real-time ATP assay and glucose/lactate levels by radiometry. Levels of glutathione, NADP/NADPH and reactive oxygen species [ROS] were measured by luminescence. Following exposure to PA both cell lines showed structural changes in mitochondria that were in line with
a measured reduction in oxidative phosphorylation and increased glycolysis. These changes were more marked in T-47D, which had poorer mitochondrial function at baseline. PA was processed and expelled from the cells via the mercapturic pathway, which consumes glutathione. Nevertheless, glutathione levels were increased after 24 hours of exposure to PA, implying enhanced synthesis. Redox balance was not much affected and ROS levels were not increased. We conclude that PA is metabolically processed and expelled from cells, leading indirectly to increased glutathione levels with minimal effects on redox balance. The most marked effect was on mitochondrial structure and metabolic function implying that effects of PA may depend on mitochondrial fitness.
Midterm Survival of a Varus–Valgus Constrained Implant following One-Stage Revision for Periprosthetic Joint Infection: A Single-Center Study
Authors: Ji Baochao , Li Guoqing , Zhang Xiaogang , Wang Yang , Mu Wenbo , Cao Li 
Published: September 2021

AbstractRevision total knee arthroplasty (TKA) is challenging to perform in patients with periprosthetic joint infection (PJI) due to the difficulty of eradicating the infection and potential for bone and ligamentous deficits. The current study aimed to evaluate the midterm survival of varus–valgus constrained (VVC) implants used in one-stage revision TKA for chronic PJI at our institution. This retrospective analysis included 132 patients with chronic PJI who underwent one-stage revision using a VVC implant. The average follow-up was 51.6 months (range: 24–85 months). Five-year survival analysis was performed to set recurrent infection and mechanical failure as the end point. Hospital for special surgery (HSS) as functional outcomes was evaluated preoperatively and at the latest follow-up. A total of 12 patients (9.1%) underwent retreatment for reinfection (nine patients) and mechanical failure (three patients). The overall 5-year revision-free survival was 82.7%, the infection-free survival was 91.1%, and the mechanical failure-free survival was 98.3%. The preoperative HSS knee score improved from 35.6 points (range: 24.3–47.7 points) preoperatively to 76.8 points (range: 57.2–87.6 points) at the latest follow-up. Complications were identified in 20 patients (15.2%) which included aseptic osteolysis in 4 cases, acceptable flexion instability in 3 cases, arthrofibrosis in 2 patients, hematomas in 2 cases, calf intermuscular venous thrombosis in 6 patients, and femoral stem tip pain in 3 cases. This is the first study to report the outcomes of one-stage revision using VVC implants for knee PJI. Improved functional outcomes and good midterm survival are demonstrated at an average follow-up of 51.6 months.
Surgical Ablation of Permanent Atrial Fibrillation: Age, LV Dilatation, Obesity
Authors: Rohrbach Susanne , Dominik Elisabeth , Mirow Nikolas , Vogt Sebastian , Böning Andreas , Niemann Bernd 
Published: September 2021

Abstract
Objectives Although concomitant surgical ablation can help to reach freedom from atrial fibrillation (FREEAF) even in patients with permanent atrial fibrillation (AF), some cardiac surgeons hesitate to perform concomitant ablation to avoid perioperative risk escalation. Here, we investigated outcome and predicators of therapeutic success of concomitant surgical ablation in an all-comers study.
Methods Ablation-naïve patients with formerly accepted permanent AF (FAP, n = 41) or paroxysmal AF (parAF, n = 24) underwent concomitant epicardial bipolar radio frequency ablation and implantable loop recorder (ILR) at two surgical departments. Follow-up examination for 24 months included electrocardiogram, ILR readout, 24h Holter monitoring, echocardiography, and blood sampling.
Results Eighty-six percent of parAF and 70% of FAP patients reached FREEAF (month 24). Mortality was low (parAF/FAP: 5.3 ± 0.2%/4.1 ± 0.3%; p < 0.05; EuroScoreII; 6.1 ± 0.7%/6.4 ± 0.4%, p = ns) and no strokes occurred. FREEAF induced atrial reverse remodeling (left atrial [LA] diameter: −6.7 ± 2.2 mm) and improved cardiac function (left ventricular ejection fraction [LVEF]: +7.3 ± 2.8%), while AF resulted in further atrial dilation (+8.0 ± 1.0 mm, p < 0.05) and LVEF reduction (−7.0 ± 1.3%, p < 0.05). Higher LV (odds ratio [OR]: 1.164) and LA diameter (OR: 1.218), age (OR: 1.180) and body mass index (BMI) (OR: 1.503) increased the risk factors of AF recurrence. Patients remaining in sinus rhythm (SR) demonstrated a decrease in BMI, while AF recurrence was associated with stable overweight. Further aging did not reduce FREEAF.
Conclusions Long-term SR is achievable by concomitant surgical ablation even in FAP patients. Therefore, it should be offered routinely. Obesity influences therapeutic long-term success but may also offer addressable therapeutic targets to reach higher FREEAF rates.
Second Attempt of Guided Tissue Regeneration on a Previous Successfully Grafted Site with Periodontal Breakdown—A 5-Year Follow-up
Authors: Foo Lean Heong 
Published: September 2021

AbstractGuided tissue regeneration (GTR) has been proven to promote attachment and regeneration of periodontal tissue. However, there is a 20 to 40% incidence of attachment loss on regenerated attachments reported in the literature. To my knowledge, this is the first case report on a second attempt in GTR on a previous successful grafted site with clinical attachment loss. A healthy 17-year-old Chinese male patient had GTR performed with xenograft particles and bovine resorbable membrane on his root-canal treated, fused upper right lateral incisor and upper right canine (#12-#13) in 2007. Probing depth on the mid-palatal region of #12-#13 was reduced to 4 mm and maintained for the next 4 years. But in the fifth year, probing depth increased to 11 mm with no endodontic symptoms, and a second attempt of GTR using the same materials was carried out. The probing depth at the surgical site was reduced to 4 mm and successfully maintained for another 5 years. Irregular maintenance and the presence of plaque retentive factor could have caused the clinical attachment loss on #12-#13. This case shows it is possible to attempt GTR on a previous successfully grafted site. GTR did not increase tissue resistance against periodontal breakdown. Hence, proper maintenance planning for GTR sites is important to prevent periodontal breakdown.
Circulation of DENV-3 Genotype 3 during 2017 to 2018 in Delhi: A Single-Center Hospital-Based Study
Authors: Padhi Abhishek , Gupta Ekta , Singh Gaurav , Parveen Shama , Islam Arshi , Tarai Bansidhar 
Published: September 2021

AbstractIntroduction Delhi is hyperendemic for dengue virus (DENV) where all the four DENV have previously been reported. A constant vigilance of circulating DENV serotypes is important in surveillance, since the introduction of a new variant to areas affected by preexisting serotypes constitutes a risk factor for dengue hemorrhagic fever and dengue shock syndrome.Objectives This retrospective study was performed with an objective to determine the circulating serotype and genotype of DENV in acute phase blood samples of patients who have reported to a tertiary liver care hospital in New Delhi during the last 2 years (2017–2018).Methods The data of clinician-initiated testing for dengue nonstructural protein 1 (NS1) antigen (Ag) was searched in the institutional hospital information system. The serum sample of dengue NS1 Ag-positive cases confirmed by enzyme-linked immunosorbent assay (ELISA; PANBIO, Gyeonggi-do, ROK) and a fever duration of less than 5 days were retrieved from the laboratory archive. The DENV serotyping on these sample was performed by reverse transcriptase polymerase chain reaction (RT-PCR). Sequencing and phylogenetic analysis was done for the capsid premembrane (CprM) region to determine the genotype.Results A total of 440 acute-phase samples were received. Twenty one (4.77%) were positive for dengue NS1 Ag with a mean age of 35.1 years and male-to-female ratio of 1.1:1. Eight cases (38.09%) were positive by dengue RT-PCR and all belonged to DENV-3 serotypes. Phylogenetic tree analysis revealed DENV-3 clustered to genotype III with 100% homology with 2008 Indian subcontinent strain.Conclusion This study revealed circulation of DENV-3, genotype III in Delhi from 2017 to 2018, similar to the 2008 viral type. Virological surveillance is an important exercise to be done for viral infections with public threat and outbreak potential.
A Scoping Review of Artificial Intelligence Algorithms in Clinical Decision Support Systems for Internal Medicine Subspecialties
Authors: Narindrarangkura Ploypun , Kim Min Soon , Boren Suzanne A. 
Published: September 2021

AbstractObjectives Artificial intelligence (AI)-based clinical decision support systems (CDSS) have been developed to solve medical problems and enhance health care management. We aimed to review the literature to identify trends and applications of AI algorithms in CDSS for internal medicine subspecialties.Methods A scoping review was conducted in PubMed, IEEE Xplore, and Scopus to determine articles related to CDSS using AI algorithms that use deep learning, machine learning, and pattern recognition. This review synthesized the main purposes of CDSS, types of AI algorithms, and overall accuracy of algorithms. We searched the original research published in English between 2009 and 2019.Results Given the volume of articles meeting inclusion criteria, the results of 218 of the 3,467 articles were analyzed and presented in this review. These 218 articles were related to AI-based CDSS for internal medicine subspecialties: neurocritical care (n = 89), cardiovascular disease (n = 79), and medical oncology (n = 50). We found that the main purposes of CDSS were prediction (48.4%) and diagnosis (47.1%). The five most common algorithms include: support vector machine (20.9%), neural network (14.6%), random forest (10.5%), deep learning (9.2%), and decision tree (8.8%). The accuracy ranges of algorithms were 61.8 to 100% in neurocritical care, 61.6 to 100% in cardiovascular disease, and 54 to 100% in medical oncology. Only 20.1% of those algorithms had an explainability of AI, which provides the results of the solution that humans can understand.Conclusion More AI algorithms are applied in CDSS and are important in improving clinical practice. Supervised learning still accounts for a majority of AI applications in internal medicine. This study identified four potential gaps: the need for AI explainability, the lack of ubiquity of CDSS, the narrow scope of target users of CDSS, and the need for AI in health care report standards.
Virtual Learning Improves Attendance for Critical Care Education During the COVID-19 Pandemic
Authors: Scioscia Andrea , Rakkar Jaskaran , Pelletier Jonathan H. , Ghassemzadeh Rod , Hamilton Melinda F. , Fuhrman Dana Y. 
Published: September 2021

AbstractThe COVID-19 pandemic has pushed medical educators and learners to adapt to virtual learning (VL) in an expedited manner. The effect of VL for critical care education has not yet been evaluated. In a quantitative analysis of survey data and attendance records, we sought to determine the association of VL with conference attendance and work-life balance. Attending physicians, fellows, and advanced practice providers (APP) at a pediatric critical care department at a quaternary children's hospital participated in the study. Attendance records were obtained before and after the adaption of a VL platform. In addition, an electronic, anonymous survey to evaluate current satisfaction and the strengths and weaknesses of VL as well as its impact on work-life balance was administered. In total, 31 learners (17 attending physicians, 13 fellows, and 1 APP) completed the survey. A total of 83.9% (26/31) of participants were satisfied, and 77.4% (24/31) found VL to be similar or more engaging than non-VL. However, 6.5% (2/31) of learners reported difficulty in using the new platform, 87% (27/31) of participants supported VL as an effective learning tool, and 83.3% (25/30) reported a positive impact on work-life balance. Additionally, median monthly conference attendance increased significantly from 85 to 114 attendees per month (p < 0.05). Our results suggest that a virtual model has advantages for overall attendance and work-life balance. We anticipate VL will continue to be an integral part of medical education. Future work evaluating the impact of VL on interdepartmental and interinstitutional collaborations is needed.
Experimental confirmation of long hyperbolic polariton lifetimes in monoisotopic (10B) hexagonal boron nitride at room temperature
Authors: Pavlidis Georges , Schwartz Jeffrey J. , Matson Joseph , Folland Thomas , Liu Song , Edgar James H. , Caldwell Josh D. , Centrone Andrea 
Published: September 2021

Hyperbolic phonon polaritons (HPhPs) enable strong confinements, low losses, and intrinsic beam steering capabilities determined by the refractive index anisotropy—providing opportunities from hyperlensing to flat optics and other applications. Here, two scanning-probe techniques, photothermal induced resonance (PTIR) and scattering-type scanning near-field optical microscopy (s-SNOM), are used to map infrared (6.4–7.4 µm) HPhPs in large (up to 120 × 250 µm2) near-monoisotopic (&gt;99% 10B) hexagonal boron nitride (hBN) flakes. Wide (≈40 µm) PTIR and s-SNOM scans on such large flakes avoid interference from polaritons launched from different asperities (edges, folds, surface defects, etc.) and together with Fourier analyses (0.05 µm−1 resolution) enable precise measurements of HPhP lifetimes (up to ≈4.2 ps) and propagation lengths (up to ≈25 and ≈17 µm for the first- and second-order branches, respectively). With respect to naturally abundant hBN, we report an eightfold improved, record-high (for hBN) propagating figure of merit (i.e., with both high confinement and long lifetime) in ≈99% 10B hBN, achieving, finally, theoretically predicted values. We show that wide near-field scans critically enable accurate estimates of the polaritons’ lifetimes and propagation lengths and that the incidence angle of light, with respect to both the sample plane and the flake edge, needs to be considered to extract correctly the dispersion relation from the near-field polaritons maps. Overall, the measurements and data analyses employed here elucidate details pertaining to polaritons’ propagation in isotopically enriched hBN and pave the way for developing high-performance HPhP-based devices.
Sphingolipid metabolism governs Purkinje cell patterned degeneration in
Atxn1[82Q]/+
mice
Authors: Blot François G. C. , Krijnen Wilhelmina H. J. J. , Den Hoedt Sandra , Osório Catarina , White Joshua J. , Mulder Monique T. , Schonewille Martijn 
Published: September 2021

Significance
Neuronal subtypes are differentially affected by neuropathologies. For example, Purkinje cells, the principal neurons of the cerebellum, can be divided in subpopulations based on their sensitivity to pathological insult. However, the molecular mechanisms explaining why, among seemingly identical neurons, some will degenerate while others survive remain unknown. Here, we analyzed, in a disease model of cerebellar neurodegeneration, the metabolism of sphingolipids, complex lipids involved in cell apoptosis, and found that specific sphingolipids accumulate in the cerebellar region primarily affected by neurodegeneration. Preventing this accumulation by disrupting sphingolipid metabolism via genetic mutation caused a neuroprotective effect on subpopulations of Purkinje cells. Thus, our data indicate that sphingolipid metabolism is involved in the predisposition of neuronal subtypes to neurodegeneration.
Intrinsic physicochemical profile of marketed antibody-based biotherapeutics
Authors: Ahmed Lucky , Gupta Priyanka , Martin Kyle P. , Scheer Justin M. , Nixon Andrew E. , Kumar Sandeep 
Published: September 2021

Significance
Successful biologic drug discovery and development involves finding functional as well as developable candidates. Once a candidate has been demonstrated to be functional, the next step is to determine whether it can be translated into a drug product. This requires that the candidate can withstand stresses encountered during manufacturing, shipping, and storage. Additionally, it must be safe, efficacious, and possess good pharmacology. In silico analyses of the variable regions of 77 marketed antibody-based biotherapeutics have revealed five nonredundant physicochemical descriptors. Distributions of these descriptors, observed for marketed biotherapeutics, can help prioritize a drug candidate for experimental testing at early discovery stages, guide engineering efforts to further optimize it, and help increase the productivity of biologic drug discovery and development.
AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase
Authors: Yoshihama Yohei , LaBella Kyle A. , Kim Eiru , Bertolet Lori , Colic Medina , Li Jiexi , Shang Xiaoying , Wu Chang-Jiun , Spring Denise J. , Wang Y. Alan , Hart Traver , DePinho Ronald A. 
Published: September 2021

Significance
Prostate cancer is a major cause of cancer-related death in men. Emerging resistance to androgen receptor (AR) signaling inhibition therapy has heightened the need to identify therapeutic vulnerabilities specific to AR-negative prostate cancers. Analysis of CRISPR screen datasets in human prostate cancer cells identified high dependency for the histone demethylase JMJD1C across multiple AR-negative model systems. Integrated analyses revealed that combined AR and JMJD1C inactivation drives up-regulation of the TNFα network which provokes growth suppression. The exquisite sensitivity of AR-negative prostate cancer cells to JMJD1C inhibition may provide a therapeutic option for men with progressive castration-resistant prostate cancer.
Secure human attachment can promote support for climate change mitigation
Authors: Nisa Claudia F. , Bélanger Jocelyn J. , Schumpe Birga M. , Sasin Edyta M. 
Published: September 2021

Significance
Attachment theory focuses on the primal form of emotional bonding between humans. Attachment is conceptualized as an innate behavioral system aimed at safeguarding against potential threats by assuring proximity to caring and supportive others. When individuals feel securely attached (thus feeling less threatened in most situations), the activation of the caregiving behavioral system (concern for others) is facilitated. With this research, we show that priming attachment security influences how much people care about and accept climate change via an increased empathy for humanity. Furthermore, we demonstrate that this activation bypasses the resistance of politically conservative individuals to mitigate climate change. Overall, we show that attachment security–based stimuli can inform intervention and policymaking strategies to help fight climate change.