bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stochastic Numerical Investigations for a Food Web System of Prey-Predation, Competition and Commensalism
Authors: Sabir Zulqurnain , N Seshagiri Rao , K Kalyani 
Published: December 2021

Abstract
Employing Levenberg-Marquardt backpropagation(LMB) neural network, the system of three species nonlinear equations are illuminated by designing an integrated numerical computing-based plot. The proposed dynamical system comprises of two competing species which are growing logistically in nature and, the third species is predating with Holling type II functional response mode on second species and also acts host for the first prey species. Besides, the prey species protect themselves to refuge high predation. The designed LMB neural network has been used to exhibits the solutions of the dynamical frame work. In each case of the species, a reference dataset of the planned LMB neural network is initiated in comparison of Adam numerical program. The approximate results of the food web system are displayed within the training, confirmation and testing strategies to redesign the neural network to minimize the mean square error (MSE) function employing the designed LMB. The investigations depend on the corresponding achievements and the examinations based on MSE out comes, correlation, regression and error histograms signify the proficiency, rightness as well as the potency of the suggested LMB neural network conspire.
Conspicuity and imaging features of breast cancers on digital breast tomosynthesis according to molecular profile
Authors: Manse Léa , Boisserie-Lacroix Martine , Brouste Véronique , Depetiteville Marie-Pierre , Mesurolle Benoît , Chamming's Foucauld 
Published: December 2021

Abstract
Objective
To describe BI-RADS features and evaluate conspicuity of breast cancer on digital breast tomosynthesis (DBT) according to their molecular profile.
Materials and method
Institutional review board was obtained for this retrospective study. Consecutive patients with histologically proven breast cancers who underwent digital breast tomosynthesis (DBT) with 2D synthetic mammography (SM) and digital mammography (DM) at the time of diagnosis were included. Morphological features and conspicuity of cancers on DM, SM and DBT were evaluated in consensus by two breast radiologists. Imaging features were compared across molecular subtypes (luminal, triple negative (TN) and HER2+) using Fisher’s exact test and between DBT and SM and DM using McNemar’s test. Conspicuity was compared between DBT and SM and DM using Wilcoxon matched pairs test and between each molecular subtype using the Wilcoxon test.
Results
One hundred and eleven consecutive patients were included. On DBT, TN cancers more frequently presented as masses with microlobulated margins (P = 0.04) while HER2 + cancers were more often associated with microcalcifications (P = 0.02). Greater conspicuity on DBT in comparison to DM was observed for cancers with low Ki67 (P = .015), less aggressive tumours (P = .005), positive ER (P = 0.005), positive PR (P = .005) or negative HER2 (P = .024), and for luminal molecular profiles (P = 0.012) while no difference was observed between the two techniques for TN (P = .73) and HER+ (P = .79) tumours.
Conclusion
DBT reveals specific features of breast cancers according to their molecular characteristics. In comparison with DM, DBT improves conspicuity of luminal subtype cancers and tumours demonstrating less aggressive features on pathology.
Exploiting Synthetic Lethal Network for Precision Treatment of Clear Cell Renal Cell Carcinoma
Authors: Liu Zhicheng , Lin Dongxu , Zhang Linmeng , Yang Chen , Guo Bin , Xia Feng , Li Yan , Chen Danyang , Wang Cun , Xiao Zhenyu , Chen Zhong , Leng Chao 
Published: December 2021

Abstract
Background

The emerging of targeted therapies has revolutionized the treatment modalities of advanced clear cell renal cell carcinoma (ccRCC) over the past fifteen years. However, lack of personalized treatment limits the development of effective clinical guidelines and improvement of patient prognosis. In this study, large-scale genomic profiles of ccRCC cohorts were exploited for conducting an integrative analysis.
Method

Based on synthetic lethality (SL), a concept that simultaneous losses of two genes cause cell death while a single loss does not, we sought to develop a computational pipeline to infer potential SL partners of ccRCC. Drug response prediction were received from three pharmacological databases to select agents which are likely to be effective in precisely treating patients with target gene mutation.
Results

We developed a credible method to identify SL pairs and determined a list of 72 candidate pairs which might be utilized to selectively eliminate tumors with genetic aberrations through SL partners of specific mutations. Further analysis identified BRD4 and PRKDC as novel medicine targets for patients with BAP1 mutations. After mapping these target genes to comprehensive drug datasets, two agents (BI-2536 and PI-103) were found to have considerable therapeutic potential in BAP1 mutant tumors.
Conclusion

Overall, our findings provide insight into the overview of ccRCC mutation patterns and offer novel opportunities for improving individualized cancer treatment.
Progress on legal and practical aspects on water reuse with emphasis on drinking water – an overview
Authors: Santos Ana Silvia Pereira , Pachawo Vimbai , Melo Marilia Carvalho , Vieira José Manuel Pereira 
Published: December 2021

Abstract
The present study highlights the evolution, progress and prospects of future practices of water reuse in the world. The objective was to produce a comprehensive timeline on the global evolution and progress of water reuse. This was achieved through the analysis of the state of the art on the subject. The present study is a qualitative research, where three aspects have been considered to highlight the global evolution of water reuse: i) Regulations, Standards, Criteria or Guidelines (RSCG); ii) Indirect Potable Reuse Projects (IPR); and iii) Direct Potable Reuse Projects (DPR). The study focused on both legal and practical aspects of water reuse and considered three timelines in the context of RSCG, IPR and DPR: 29 RSCG instruments, institutionalized from 1918 to 2020, where only four instruments were solely dedicated to drinking water reuse; 10 IPR projects; five DPR projects. To achieve good, effective results, the regulatory framework must support the objectives of a structured water reuse policy in addition to guaranteeing legitimacy and maintaining public confidence. Integrated water and wastewater management, based on technological and scientific advances, has become a relevant aspect for implementation of more adequate measures by decision makers to address future global water challenges.
IoT-based performance analysis of hybrid solar heater-double slope solar still
Authors: Benghanem M. , Mellit A. , Emad M. 
Published: December 2021

Abstract
Remote monitoring of solar still systems is an interesting step for performance analysis and supervision. In this article, a monitoring system is developed and integrated to a solar still system. The parameters considered (such as air temperatures, relative humidity, etc) have been posted on a webpage via the Internet of Things (IoT) technique. For this, the ThingSpeak platform of MathWorks is used. The results demonstrate that ground water after desalination has practically the same chemical parameter values as mineral water (Nestle) and ordinary home drinking water. It has also been confirmed that by adding a solar preheater, the process of evaporation of saline water has been accelerated, which permits improvement of the efficiency of the proposed prototype.
Urolitiasis de estruvita en perros: Características epidemiológicas y clínicas en México
Authors: Aké-Chiñas María Alejandra , Mendoza-López Claudia Iveth , Del-Angel-Caraza Javier , Quijano-Hernández Israel Alejandro , Rodrigez-Alarcón Carlos Arturo , Barbosa-Mireles Marco Antonio 
Published: December 2021

Objetivo. Identificar factores de riesgo demográficos y características clínicas de la urolitiasis de estruvita en perros de México. Animales. Casos clínicos de perros con urolitiasis de estruvita obtenidos de la base de datos del laboratorio de análisis de urolitos del 2012-2017. Materiales y Métodos. Se realizó un estudio transversal comparativo para identificar factores de riesgo demográficos mediante la comparación de casos entre dos grupos. En la descripción de las características clínicas se utilizaron datos clínicos de los casos. El análisis estadístico incluyó prueba de X2, razón de probabilidades (OR) e intervalo de confianza del 95%, considerando como valor significativo una p<0.05. El análisis de regresión logística multivariada se utilizó para identificar asociación entre factores. Resultados. La frecuencia de la urolitiasis de estruvita fue del 41.2%. Las hembras tuvieron mayor probabilidad de desarrollar esta urolitiasis (p<0.05; p<0.001) en todos los grupos de comparación, asi como los animales de talla pequeña (p<0.01) con respecto a los de talla grande. Asociaciones entre un diagnóstico de urolitiasis de estruvita y las razas individuales y edad fueron identificadas. Las características clínicas encontradas fueron pH urinario ≥7, densidad urinaria ≥1.025, presencia de urolitos moderadamente radiopacos ≥30 mm y únicos en vejiga de las hembras. La recurrencia fue más frecuente entre el primer y segundo año (56.7%). Conclusiones. La identificación de los factores demográficos y de las características clínicas ayudará a los clínicos veterinarios a predecir la composición mineral del urolito de estruvita, y así poder considerar la disolución médica como tratamiento.
Concept Libraries for Repeatable and Reusable Research: Qualitative Study Exploring the Needs of Users
Authors: Almowil Zahra , Zhou Shang-Ming , Brophy Sinead , Croxall Jodie 
Published: December 2021

Background
Big data research in the field of health sciences is hindered by a lack of agreement on how to identify and define different conditions and their medications. This means that researchers and health professionals often have different phenotype definitions for the same condition. This lack of agreement makes it difficult to compare different study findings and hinders the ability to conduct repeatable and reusable research.

Objective
This study aims to examine the requirements of various users, such as researchers, clinicians, machine learning experts, and managers, in the development of a data portal for phenotypes (a concept library).

Methods
This was a qualitative study using interviews and focus group discussion. One-to-one interviews were conducted with researchers, clinicians, machine learning experts, and senior research managers in health data science (N=6) to explore their specific needs in the development of a concept library. In addition, a focus group discussion with researchers (N=14) working with the Secured Anonymized Information Linkage databank, a national eHealth data linkage infrastructure, was held to perform a SWOT (strengths, weaknesses, opportunities, and threats) analysis for the phenotyping system and the proposed concept library. The interviews and focus group discussion were transcribed verbatim, and 2 thematic analyses were performed.

Results
Most of the participants thought that the prototype concept library would be a very helpful resource for conducting repeatable research, but they specified that many requirements are needed before its development. Although all the participants stated that they were aware of some existing concept libraries, most of them expressed negative perceptions about them. The participants mentioned several facilitators that would stimulate them to share their work and reuse the work of others, and they pointed out several barriers that could inhibit them from sharing their work and reusing the work of others. The participants suggested some developments that they would like to see to improve reproducible research output using routine data.

Conclusions
The study indicated that most interviewees valued a concept library for phenotypes. However, only half of the participants felt that they would contribute by providing definitions for the concept library, and they reported many barriers regarding sharing their work on a publicly accessible platform. Analysis of interviews and the focus group discussion revealed that different stakeholders have different requirements, facilitators, barriers, and concerns about a prototype concept library.
An Internet-Based Cognitive Behavioral Therapy Program for Anxiety and Depression (Tranquility): Adaptation Co-design and Fidelity Evaluation Study
Authors: Patterson Victoria C , Rossi Meghan A , Pencer Alissa , Wozney Lori 
Published: December 2021

Background
Internet-based cognitive behavioral therapy (iCBT) is a necessary step toward increasing the accessibility of mental health services. Yet, few iCBT programs have been evaluated for their fidelity to the therapeutic principles of cognitive behavioral therapy (CBT) or usability standards. In addition, many existing iCBT programs do not include treatments targeting both anxiety and depression, which are commonly co-occurring conditions.

Objective
This study aims to evaluate the usability of Tranquility—a novel iCBT program for anxiety—and its fidelity to CBT principles. This study also aims to engage in a co-design process to adapt Tranquility to include treatment elements for depression.

Methods
CBT experts (n=6) and mental health–informed peers (n=6) reviewed the iCBT program Tranquility. CBT experts assessed Tranquility’s fidelity to CBT principles and were asked to identify necessary interventions for depression by using 2 simulated client case examples. Mental health–informed peers engaged in 2 co-design focus groups to discuss adaptations to the existing anxiety program and the integration of interventions for depression. Both groups completed web-based surveys assessing the usability of Tranquility and the likelihood that they would recommend the program.

Results
The CBT experts’ mean rating of Tranquility’s fidelity to CBT principles was 91%, indicating a high fidelity to CBT. Further, 5 out of 6 CBT experts and all mental health–informed peers (all participants: 11/12, 88%) rated Tranquility as satisfactory, indicating that they may recommend Tranquility to others, and they rated its usability highly (mean 76.56, SD 14.07). Mental health–informed peers provided suggestions on how to leverage engagement with Tranquility (eg, adding incentives and notification control).

Conclusions
This preliminary study demonstrated the strong fidelity of Tranquility to CBT and usability standards. The results highlight the importance of involving stakeholders in the co-design process and future opportunities to increase engagement.
UPAYA PENYELESAIAN SENGKETA DELIMITASI BATAS MARITIM DI WILAYAH GREATER SUNRISE ANTARA TIMOR LESTE DAN AUSTRALIA DARI PERSPEKTIF KAJIAN HUKUM PERJANJIAN INTERNASIONAL
Authors: Nauli Putriana Septi , Sinambela Stivani Ismawira 
Published: December 2021

<span>Penulisan penelitian ini berdasarkan konflik permasalahan batas laut Timor Leste dengan Australia.Tulisan ini bertujuan untuk mengetahui bagaimana penyelesaian permasalahan batas maritim antara Australia dan Timor Leste dan apa yang menjadi kepentingan kedua Negara. Konflik antar Negara dapat terjadi akibat batas-batas teritorial suatu negara telah dilanggar. Delimitasi batas maritim sebagai implementasi penentuan batas-batas wilayah laut antara negara. Dalam penyelesaian delimitasi batas maritim sengketa antara negara Timor Leste dan Australia adanya campur tangan oleh pihak ketiga yakni Arbitrase atau Mahkamah Internasional, sesuai dengan ketentuan konvensi UNCLOS 1982. Pada tahun 2016 Timor leste Arbitrase atau mahkamah Internasional turut campur tangan dalam penyelesaian antar timor Leste dan Australia. Greater Sunrise merupakan ladang minyak di Laut Timor dari pembagian hasil sumber daya minyak yang tidak merata bagi Timor Leste menjadi salah satu pemicu konflik delimitasi batas maritim. Pada kasus ini Penulis juga bermasud untuk mengetahui secara detail bagaimana perjanjian atau kesepakatan yang dilakukan Australia dan Timor Leste dalam penyelesaian masalah delimitasi batas maritim. Dalam studi kasus ini penulis tersebut penulis juga ingin mengetahui apa yang menjadi kesepakatan Australia dan Timor Leste dalam pembagian wilayah Greater Sunrise.</span>
Padrões insustentáveis de consumo: um panorama do desequilíbrio global nos hábitos individuais e suas consequências para o Desenvolvimento Sustentável
Authors: De Castro Aline Eggres , Trevisan Marcelo 
Published: December 2021

Hábitos ostensivos de consumo têm se consolidado nos debates sobre o Desenvolvimento Sustentável como um dos principais causadores da crise ambiental enfrentada pelo planeta. O estudo tem por objetivo debater os temas relacionados aos hábitos de consumo excessivos praticados por populações economicamente favorecidas – especialmente pertencentes aos países desenvolvidos do hemisfério norte –, em contraste com o consumo insuficiente ao qual grande parte da população mundial – principalmente dos países em desenvolvimento do hemisfério sul – é submetida devido à falta de acesso aos recursos. Para tanto, foi revisado o estado da arte relacionado às temáticas do Desenvolvimento Sustentável, padrões insustentáveis de consumo (consumo excessivo nas classes médias e altas e consumo insuficiente na base da pirâmide) e estratégias de mudanças nos hábitos de consumo – consumo verde, consumo consciente e consumo sustentável. Tais conceitos muitas vezes são confundidos ou até mesmo utilizados como sinônimos na literatura, sem especificar uma diferenciação clara entre eles. Para esse estudo buscou-se um significado mais profundo para cada termo, a fim de compreender melhor a evolução do pensamento social relacionado aos hábitos de consumo e o papel do consumidor nesse processo. Com isso, foram feitos vínculos entre os temas e os resultados das análises evidenciaram que os hábitos excessivos têm consequências diretas na degradação ambiental e social as quais as populações desfavorecidas são submetidas. Para reverter esse quadro é fundamental uma mudança de hábitos que inclua o pensamento coletivo nas decisões individuais.
Confirmation Bias and Auditor Risk Assessments: Archival Evidence
Authors: Cassell Cory A. , Dearden Stuart M. , Rosser David M. , Shipman Jonathan E. 
Published: December 2021

SUMMARY
Judgment and decision-making research suggests that auditors' judgments are negatively affected by the use of heuristics. However, there is little research investigating whether such biases survive the quality control processes that regulators and audit firms implement to mitigate them. We investigate this by identifying a setting where one such bias—confirmation bias—is likely to manifest. Consistent with confirmation bias influencing observable audit outcomes, we find that auditors with previous experience auditing a client with a history of low risk followed by an increase in risk do not adequately respond to the higher level of risk. This effect is mitigated when the risk increase is likely large enough to violate auditors' reasonableness constraint and when the client is highly visible or has strong external monitors. Our study complements prior experimental research by providing archival evidence that auditors' use of heuristics has a significant effect on auditor judgments.
JEL Classifications: M40; M42.
Is an Emoji Worth a Thousand Words? The Effect of Emoji Usage on Nonprofessional Investors' Perceptions
Authors: Carrillo Hilda E. , Pennington Robin , Zhang Yibo (James) 
Published: December 2021

ABSTRACT
Emojis act as non-verbal cues to disambiguate and communicate affect and are increasingly used in online corporate disclosures. Emotion work, a concept founded in social psychology, suggests that individuals adjust their behavior as emotions are evoked or suppressed. Despite the growing evidence that emojis may influence judgments and decisions due to their deliberate expression of context and affect, the accounting research community has yet to investigate emojis' impact. We experimentally explore whether emojis can soften nonprofessional investors' perceptions of bad news or enhance perceptions of good news. We find that emojis modestly suppress participants' positive emotions on positive news, influencing their investment-related judgments and decision-making. Subsequent data collection fails to replicate the initial findings in a less experienced participant pool, suggesting that investing experience may play a role. Our study enhances our understanding of the unintended consequences of emojis and introduces a sociology-based principle into the accounting literature.
Data Availability: Please contact authors.
Ja eller nei til Huawei? En analyse av hvordan små og mellomstore stater stiller seg til den kinesiske gigantens rolle i 5G
Authors: Christie Øystein 
Published: December 2021

Artikkelen ser på den teknologiske og strategiske rivaliseringen mellom USA og Kina hva gjelder implementeringen av 5G-nettverk, og spør hva som er med å påvirke hvordan andre stater posisjonerer seg mellom de to supermaktene. Ved å bygge på tre grener av politisk realisme – balance-of-threat-teoriens tanke om at trusseloppfatning driver staters valg av allianser, patron–klient-teoriens tro på at USA kan forvente at deres klientstater innretter seg etter amerikansk utenrikspolitikk, og teorien om at handelsrelasjoner kan brukes som maktverktøy – utleder jeg et sett med hypoteser og potensielt relevante forklaringsvariabler. Som avhengig variabel samler jeg 70 staters holdninger til Kinas omstridte telekommunikasjonsgigant Huaweis rolle i 5G. Bivariat analyse avslører tre hovedmønstre: (1) Stater som er små og maktesløse i forhold til Kina, samt statene i Kinas geografiske region, ser ut til å være mer aksepterende til Huaweis 5G. (2) Stater som ser på USA som sin patron og som er avhengige av Washingtons sikkerhetsgaranti ser ut til å være betydelig mer avvisende til selskapets 5G. (3) Handelsrelasjoner til både USA og Kina ser ut til å ha liten eller ingen effekt på staters holdninger. Av de tre realisme-grenene er det altså patron–klient-teorien som veier tyngst når det gjelder å forklare staters holdninger til Huaweis 5G.
Abstract in English:The US way or the Huawei: An analysis of how small and medium states stand on the Chinese giant’s role in 5GThis article examines the technological and strategic rivalry between the US and China on the implementation of 5G networks, asking what influences how other states position themselves between the two superpowers. By building on three branches of political realism – balance-of-threat theory’s notion that perception of threat drives states’ alliance choices, patron-client theory’s belief that the US can expect its client states to adhere to American foreign policy, and the theory that trade relations can be used as power tools – I derive a set of hypotheses and potentially relevant explanatory variables. As dependent variable, I measure 70 states’ stances on China’s controversial telecom giant Huawei’s role in 5G. Bivariate analysis reveals three primary patterns: (1) States who are dwarfed by China’s power, as well as states in China’s immediate geographic region, appear to be more acceptive of Huawei’s 5G. (2) States who see the US as their patron and who rely on Washington’s security guarantee appear to be much more rejective of the company’s 5G. (3) Trade relations to both the US and China appear to have little or no effect on states’ stances. Of the three branches of realism, it is the patron-client theory that offers the most weight in explaining states’ stances on Huawei’s 5G.