bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anchor voiceprint recognition in live streaming via RawNet-SA and gated recurrent unit
Authors: Yao Jiacheng , Zhang Jing , Li Jiafeng , Zhuo Li 
Published: December 2021

AbstractWith the sharp booming of online live streaming platforms, some anchors seek profits and accumulate popularity by mixing inappropriate content into live programs. After being blacklisted, these anchors even forged their identities to change the platform to continue live, causing great harm to the network environment. Therefore, we propose an anchor voiceprint recognition in live streaming via RawNet-SA and gated recurrent unit (GRU) for anchor identification of live platform. First, the speech of the anchor is extracted from the live streaming by using voice activation detection (VAD) and speech separation. Then, the feature sequence of anchor voiceprint is generated from the speech waveform with the self-attention network RawNet-SA. Finally, the feature sequence of anchor voiceprint is aggregated by GRU to transform into a deep voiceprint feature vector for anchor recognition. Experiments are conducted on the VoxCeleb, CN-Celeb, and MUSAN dataset, and the competitive results demonstrate that our method can effectively recognize the anchor voiceprint in video streaming.
Some aspects of nonsmooth variational inequalities on Hadamard manifolds
Authors: Islam Monirul , Irfan Syed Shakaib 
Published: December 2021

AbstractThis is the first paper dealing with the study of minimum and maximum principle sufficiency properties for nonsmooth variational inequalities by using gap functions in the setting of Hadamard manifolds. We also provide some characterizations of these two sufficiency properties. We conclude the paper with a discussion of the error bounds for nonsmooth variational inequalities in the setting of Hadamard manifolds.
A case of solitary plasmacytoma of bone showing co-expression of both immunoglobulin light chains
Authors: Matsuoka Ryota , Sakamoto Noriaki , Kato Takayasu , Chiba Shigeru , Noguchi Masayuki 
Published: December 2021

Abstract
Background
Solitary plasmacytoma of bone (SPB) is a rare plasma cell neoplasm. It arises in bone as a single locus in the absence of any plasma cell myeloma lesions. Plasma cell neoplasms intrinsically express only one immunoglobulin light chain (IgL)—kappa or lambda—and using this fact, kappa/lambda deviation is the decisive factor for diagnosis. Co-expression of both IgLs in a single tumor cell is extremely rare.

Case presentation
We report a case of SPB that arose in the vertebra of a 52-year-old Japanese woman. Histologically, the resected mass showed diffuse plasma cell proliferation. Dual IgL expression was detected by flow cytometry, immunohistochemistry, and in situ hybridization (ISH) targeting IgL mRNA.

Conclusion
We have presented an extremely rare case of SPB showing dual expression of kappa and lambda IgLs. This unusual case of plasma cell neoplasia might represent a possible exceptional example of failure of “IgL isotypic exclusion.”
Glutamic acid reshapes the plant microbiota to protect plants against pathogens
Authors: Kim Da-Ran , Jeon Chang-Wook , Cho Gyeongjun , Thomashow Linda S. , Weller David M. , Paik Man-Jeong , Lee Yong Bok , Kwak Youn-Sig 
Published: December 2021

AbstractBackgroundPlants in nature interact with other species, among which are mutualistic microorganisms that affect plant health. The co-existence of microbial symbionts with the host contributes to host fitness in a natural context. In turn, the composition of the plant microbiota responds to the environment and the state of the host, raising the possibility that it can be engineered to benefit the plant. However, technology for engineering the structure of the plant microbiome is not yet available.ResultsThe loss of diversity and reduction in population density ofStreptomyces globisporusSP6C4, a core microbe, was observed coincident with the aging of strawberry plants. Here, we show that glutamic acid reshapes the plant microbial community and enriches populations ofStreptomyces, a functional core microbe in the strawberry anthosphere. Similarly, in the tomato rhizosphere, treatment with glutamic acid increased the population sizes ofStreptomycesas well as those of Bacillaceae and Burkholderiaceae. At the same time, diseases caused by species ofBotrytisandFusariumwere significantly reduced in both habitats. We suggest that glutamic acid directly modulates the composition of the microbiome community.ConclusionsMuch is known about the structure of plant-associated microbial communities, but less is understood about how the community composition and complexity are controlled. Our results demonstrate that the intrinsic level of glutamic acid in planta is associated with the composition of the microbiota, which can be modulated by an external supply of a biostimulant.
Detection of low-level parental somatic mosaicism for clinically relevant SNVs and indels identified in a large exome sequencing dataset
Authors: Domogala Daniel D. , Gambin Tomasz , Zemet Roni , Wu Chung Wah , Schulze Katharina V. , Yang Yaping , Wilson Theresa A. , Machol Ido , Liu Pengfei , Stankiewicz Paweł 
Published: December 2021

AbstractBackgroundDue to the limitations of the current routine diagnostic methods, low-level somatic mosaicism with variant allele fraction (VAF) < 10% is often undetected in clinical settings. To date, only a few studies have attempted to analyze tissue distribution of low-level parental mosaicism in a large clinical exome sequencing (ES) cohort.MethodsUsing a customized bioinformatics pipeline, we analyzed apparent de novo single-nucleotide variants or indels identified in the affected probands in ES trio data at Baylor Genetics clinical laboratories. Clinically relevant variants with VAFs between 30 and 70% in probands and lower than 10% in one parent were studied. DNA samples extracted from saliva, buccal cells, redrawn peripheral blood, urine, hair follicles, and nail, representing all three germ layers, were tested using PCR amplicon next-generation sequencing (amplicon NGS) and droplet digital PCR (ddPCR).ResultsIn a cohort of 592 clinical ES trios, we found 61 trios, each with one parent suspected of low-level mosaicism. In 21 parents, the variants were validated using amplicon NGS and seven of them by ddPCR in peripheral blood DNA samples. The parental VAFs in blood samples varied between 0.08 and 9%. The distribution of VAFs in additional tissues ranged from 0.03% in hair follicles to 9% in re-drawn peripheral blood.ConclusionsOur study illustrates the importance of analyzing ES data using sensitive computational and molecular methods for low-level parental somatic mosaicism for clinically relevant variants previously diagnosed in routine clinical diagnostics as apparent de novo.
A three-wave longitudinal study on the relation between commuting strain and somatic symptoms in university students: exploring the role of learning-family conflicts
Authors: Diebig Mathias , Li Jian , Forthmann Boris , Schmidtke Jan , Muth Thomas , Angerer Peter 
Published: December 2021

Abstract
Background
We examine the role of learning-family conflicts for the relation between commuting strain and health in a sample of medical university students. The first goal of the study was to investigate the mediating role of learning-family conflicts. The second goal was to extend the temporal view on relations between study variables. Therefore, we differentiated long-term systematic change among variables over a period of two-years from a dynamic perspective with repeated commuting events on the individual level of analyses.

Methods
We applied a multilevel research design and collected survey data from 128 medical students on three points in time (N = 339 measurement points). Participants informed about commuting strain, learning-family conflicts, somatic symptoms, as well as commuting distance and time.

Results
Bayesian multilevel analyses showed that results differed with regard to level of analysis: while learning-family conflicts mediated the relation between commuting strain and somatic symptoms on a systematic aggregation-level perspective of analysis (indirect effect estimatebetween = 0.13, SE = .05, 95% CI [0.05; ∞), Evidence Ratio = 250.57), this was not the case on the dynamic event perspective (indirect effect estimatewithin = 0.00, SE = 0.00, 95% CI [− 0.01; ∞), Evidence Ratio = 0.84).

Conclusions
We demonstrated that learning-family conflicts explain why commuting may have unfavorable effects on health for medical students. We also showed that it is the long-term commuting experience that is related to health complaints and not the single commuting event. This means that short-term deviations from general levels of commuting strain do not cause somatic symptoms, but general high levels of commuting strain do instead.
Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick
Authors: Tarantini Francesco , Cumbo Cosimo , Anelli Luisa , Zagaria Antonella , Specchia Giorgina , Musto Pellegrino , Albano Francesco 
Published: December 2021

AbstractEarly T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today.
Role of clinical pharmacists in epilepsy management at a general hospital in Vietnam: a before-and-after study
Authors: Pham Hong Tham , Tran Minh-Hoang , Nguyen Ngoc Quy , Tan Vo Van , Tran Manh Hung 
Published: December 2021

Abstract
Background
Clinical pharmacists have an important role in inter-professional healthcare collaboration for epilepsy management. However, the pharmacy practices of managing epilepsy are still limited in Vietnam, deterring pharmacists from routine adjustments of antiepileptic drugs, which could decrease the patients’ quality of life. This study aimed to assess the effectiveness of pharmacist interventions in epilepsy treatment at a Vietnamese general hospital.

Methods
A before-and-after study was conducted from January 2016 to December 2018. All patients with a diagnosis of epilepsy and being treated at the investigated hospital were recruited and screened for eligibility and exclusion criteria. The primary outcome was the proportion of patients in good control of their epilepsy (with two seizures or less in a year). The secondary outcome was the number of patients maintaining optimized concentrations within the therapeutic range of carbamazepine (4–12 mg/L), phenytoin (10–20 mg/L), or valproic acid (50–100 mg/L). Collected data were analyzed using two proportions Z-test or Chi-square test.

Results
A total of 141 participants were enrolled in the study. While most patients were given lower prescribed daily doses than the recommendations from the World Health Organization, over 56% of the participants still experienced adverse drug effects. More than half of the patients received at least one pharmacists’ intervention, which increased by 25.0% the effectiveness of the therapy (p < 0.001) and by 14.6% the number of patients with optimized drug concentrations (p = 0.018).

Conclusion
Epilepsy management requires a multiple-stepped and comprehensive approach, with a focus on the health and safety of the patients. As part of the healthcare team, pharmacists need to engage at every stage to monitor the patient’s response and determine the most effective treatment with the fewest adverse drug reactions.
Trial registration ClinicalTrials.gov, NCT04967326. Registered July 19, 2021—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04967326
Extreme IOD induced tropical Indian Ocean warming in 2020
Authors: Zhang Ying , Du Yan 
Published: December 2021

AbstractThe tropical Indian Ocean (TIO) basin-wide warming occurred in 2020, following an extreme positive Indian Ocean Dipole (IOD) event instead of an El Niño event, which is the first record since the 1960s. The extreme 2019 IOD induced the oceanic downwelling Rossby waves and thermocline warming in the southwest TIO, leading to sea surface warming via thermocline-SST feedback during late 2019 to early 2020. The southwest TIO warming triggered equatorially antisymmetric SST, precipitation, and surface wind patterns from spring to early summer. Subsequently, the cross-equatorial “C-shaped” wind anomaly, with northeasterly–northwesterly wind anomaly north–south of the equator, led to basin-wide warming through wind-evaporation-SST feedback in summer. This study reveals the important role of air–sea coupling processes associated with the independent and extreme IOD in the TIO basin-warming mode, which allows us to rethink the dynamic connections between the Indo-Pacific climate modes.
Community-based medication disposal pilot initiative in southwest tribal communities
Authors: Ampadu Isaac , Morones Robert , Tsatoke Andrea , Ampadu Lacie , Stephens Martin , Crump William C. , Bales David 
Published: December 2021

Abstract
Background
Misuse and abuse of prescription drugs including opioids has been a driving force behind the drug overdose epidemic plaguing communities across the USA for more than two decades. Medication accumulation in the home environment can contribute to this issue. However, research on proper disposal in rural communities is limited. For this project, an applied public health approach was used to raise awareness and improve prescription drug disposal practices by pilot testing prescription drug disposal systems in participating communities.

Methods
A community-based disposal project was facilitated with assistance from community partners. The project centered on distribution of drug deactivation bags in homes and medication drop boxes at multiple healthcare facilities.

Results
The team distributed 215 drug deactivation bags to 162 community households resulting in destruction of 8011 pills, 8 medicated dermal patches and 777 mL of liquid medication. A total of 4684 pounds of medication were collected and disposed of through healthcare facility drop boxes.

Conclusion
The strategies identified are scalable and easy to replicate to meet any community's needs in reducing potential challenges of medication diversion.
Morphometric measurement of the proximal tibia to design the tibial component of total knee arthroplasty for the Thai population
Authors: Phombut Chotchuang , Rooppakhun Supakit , Sindhupakorn Bura 
Published: December 2021

AbstractPurposeThis study evaluates the morphology of the Thai proximal tibia based on three-dimensional (3D) models to design the tibial component.MethodsThe 3D models of 480 tibias were created using reverse engineering techniques from computed tomography imaging data obtained from 240 volunteers (120 males, 120 females; range 20–50 years). Based on 3D measurements, a digital ruler was used to measure the distance between the triangular points of the models. The morphometric parameters consisted of mediolateral length (ML), anteroposterior width (AP), medial anteroposterior width (MAP), lateral anteroposterior width (LAP), central to a medial length (CM), central to a lateral length (CL), medial anterior radius (MAR), lateral anterior radius (LAR), and tibial aspect ratio (AR). An independent t-test was performed for gender differences, and K-means clustering was used to find the optimum sizes of the tibial component with a correlation between ML length and AP width in Thai people.ResultsThe average morphometric parameters of Thai proximal tibia, namely ML, AP, MAP, LAP, CM, and CL, were as follows: 72.52 ± 5.94 mm, 46.36 ± 3.84 mm, 49.22 ± 3.62 mm, 43.59 ± 4.05 mm, 14.29 ± 2.72 mm, and 15.28 ± 2.99 mm, respectively. The average of MAR, LAR, and AR was 24.43 ± 2.11 mm, 21.52 ± 2.00 mm, and 1.57 ± 0.08, respectively. All morphometric parameters in males were significantly higher than those of females. There was a difference between the Thai proximal tibia and other nationalities and a mismatch between the size of the commercial tibial component and the Thai knee. Using K-means clustering analysis, the recommended number of ML and AP is seven sizes for the practical design of tibial components to cover the Thai anatomy.ConclusionThe design of the tibial component should be recommended to cover the anatomy of the Thai population. These data provide essential information for the specific design of Thai knee prostheses.
Free-breathing radial 3D fat-suppressed T1-weighted gradient echo (r-VIBE) sequence for assessment of pulmonary lesions: a prospective comparison of CT and MRI
Authors: Yu Nan , Duan Haifeng , Yang Chuangbo , Yu Yong , Dang Shan 
Published: December 2021

Abstract
Purpose
To determine whether the pulmonary MR imaging with free-breathing radial 3D fat-suppressed T1-weighted gradient echo (r-VIBE) sequence can detect lung lesions and display lesion profiles with an accuracy comparable to that of computed tomography (CT), which is the reference standard in this study.

Population
Sixty-three consecutive patients were prospectively enrolled between October, 2016 and March, 2017. All the patients received both 3T MRI scanning with a free-breathing r-VIBE sequence and chest standard CT. Morphologic features of lesions were evaluated by two radiologists with a 5-point system. Chest standard CT were used as reference standard. Weighted kappa analysis and chi-squared test were used to determine both inter-observer agreement and inter-method agreement.

Results
A total of 210 solid pulmonary nodules or masses and 1 ground-glass nodule were detected by CT. Compared to CT, r-VIBE correctly detected 95.7% of pulmonary nodules, including 100% of detection rate with diameter greater than 6 mm, 92.3% of pulmonary nodules with diameter between 4 and 6 mm, and 83.3% of pulmonary nodules with diameter less than 4 mm The inter-method agreements between r-VIBE and standard-dose CT were either “substantial” or “excellent” in the evaluation of following features of pulmonary nodules with diameter more than 10mm: including lobulation, spiculation, convergence of vessels, bubble-like attenuation, cavitation and mediastinal lymph node enlargement (0.605≤K≤1.000; P<0.0001). However, K values for inter-method agreements were significant but “moderate” or “poor” for evaluating pleural tag, halo, and calcification (0.355≤ K≤0.451; P<0.0001).

Conclusion
The use of pulmonary MR imaging with r-VIBE showed high detection rate of pulmonary nodules and inter-method agreement with CT. It is also useful for nodule morphologic assessment.
Off-pump coronary artery bypass with heparin in a patient with a history of heparin-induced thrombocytopenia: a case report
Authors: Ito Yuya , Saito Aya , Shirai Yuki , Motomura Noboru 
Published: December 2021

Abstract
Background
Cardiovascular surgery for patients with a history of heparin-induced thrombocytopenia (HIT) with thrombosis requires careful perioperative anticoagulation therapy. When cardiovascular surgery is required for patients having ‘remote’ HIT, such as those who had a history of HIT and platelet factor-4/heparin antibodies turned out to be negative, it is recommended that re-exposure to heparin should be limited only to the intraoperative phase. However, few case reports have described detailed strategies for perioperative anticoagulation regimens.

Case presentation
We present the case of a 76-year-old woman, presenting with unstable angina pectoris and requiring coronary artery bypass grafting. She had a history of cardiac resuscitation and percutaneous coronary intervention for unstable angina pectoris with ventricular tachycardia 7 years prior, which caused HIT with thrombosis resulting in amputation of four fingers. On admission, platelet factor-4/heparin antibodies, biomarkers for HIT were not detected; the platelet count was 18.0 × 104/µl. Off-pump coronary artery bypass grafting was performed using heparin; argatroban infusion was continued until 9 h prior to the operation and restarted 3 h postoperatively, bridged with regular warfarin from 4 days to 3 months postoperatively. Platelet factor-4 /heparin antibodies were detected on postoperative day 8 without any clinical symptoms and became negative by day 91.

Conclusion
We consider this anticoagulation strategy is effective especially in countries, where bivalirudin is not available. Re-exposure to heparin in cardiovascular surgery for patients with a history of ‘remote HIT’ is reasonable, and appropriate anticoagulation is important for an uneventful postoperative course.
Severe reflux esophagitis after total gastrectomy successfully treated by transposition of the jejunojejunal anastomosis: a report of two cases
Authors: Nishiwaki Noriyuki , Hato Shinji , Kagawa Tetsuya , Kakishita Tomokazu , Nozaki Isao 
Published: December 2021

Abstract
Background
Reflux esophagitis after total gastrectomy is often difficult to treat. In this report, we describe two cases of reflux esophagitis that were refractory to medical therapy and successfully treated by transposition of the jejunojejunal anastomosis.

Case presentation
Case 1: A 66-year-old man underwent total gastrectomy and cholecystectomy for gastric cancer, and Roux-en-Y (RY) reconstruction was performed. The pathological diagnosis was T4aN3aM0 stage IIIC. Five months later, esophagogastroduodenoscopy identified reflux esophagitis. Although he was treated with various oral medications and was hospitalized six times, he lost 19 kg of weight. Finally, the patient was reoperated 3 years postoperatively. Intraoperative findings showed that there was no evidence of recurrence or severe adhesions that could have caused obstruction, and the anastomotic distance between the esophagojejunostomy and the jejunojejunostomy was approximately 40 cm. The jejunojejunostomy was re-anastomosed to increase the distance to 100 cm. Two years and 6 months after the reoperation, there was no recurrence of reflux esophagitis, and the patient’s weight increased by 14 kg.
Case 2: A 68-year-old woman underwent total gastrectomy and cholecystectomy for gastric cancer, and RY reconstruction was performed. The pathological diagnosis was T4aN0M0 stage IIB. Similar to Case 1, the patient was diagnosed with reflux esophagitis 5 months later. She lost 23 kg of weight and was reoperated at 6 months postoperatively. Intraoperative findings showed that there was no evidence of recurrence or severe adhesions, and transposition of the jejunojejunostomy was performed to increase the distance between anastomoses from 40 to 100 cm. Two years and 8 months after the reoperation, there was no recurrence of reflux esophagitis, and her weight increased by 15 kg.

Conclusions
Transposition of the jejunojejunostomy was an effective treatment for medication-resistant severe reflux esophagitis after total gastrectomy.