bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Stage VI Morel-Lavallée Lesion with a Large Challenging Defect
Authors: Nicolas Gregory , Abbas Laielly , Prado Ariadne , Takemura Rafael Eiki , Wada Alexandre , Souza Gomez David , Gemperli Rolf 
Published: April 2021

Summary:
Morel-Lavallée lesion (MLL) is a closed degloving soft-tissue injury that results in the accumulation of a hemolymphatic fluid between the skin/superficial fascia and the deep fascia. This is a rare injury that may be challenging to diagnose, and necessitates early identification and treatment to achieve the best outcomes. We report the case of a 45-year-old male patient who was referred to our institution for large wound closure after undergoing debridement of a misdiagnosed MLL that became complicated by infection and sepsis. The patient was retrospectively diagnosed with a Stage VI MLL and had to undergo 4 operations with skin grafting and vacuum-assisted closure therapy playing an essential role in achieving tissue closure. This case was presented as a reminder of this rare diagnosis, and the importance of considering it when faced with a patient presenting with a relevant clinical picture post trauma. An early diagnosis is important because early intervention can prevent complications and lead to better outcomes. The misdiagnosis in the case of our patient and delayed treatment led to an aggressive debridement with a large wound that was challenging to close.
Electrocorticography Analysis in Patients With Dual Neurostimulators Supports Desynchronization as a Mechanism of Action for Acute Vagal Nerve Stimulator Stimulation
Authors: Ernst Lia D. , Steffan Paul J. , Srikanth Priya , Wiedrick Jack , Spencer David C. , Datta Proleta , Joseph Navya M. , Wernovsky Magda , Becker Danielle A. 
Published: April 2021

Purpose:
Both vagal nerve stimulation (VNS) and responsive neurostimulation (RNS System) are treatment options for medically refractory focal epilepsy. The mechanism of action of both devices remains poorly understood. Limited prior evidence suggests that acute VNS stimulation may reduce epileptiform activity and cause EEG desynchronization on electrocorticography (ECoG). Our study aims to isolate effects of VNS on ECoG as recorded by RNS System in patients who have both devices, by comparing ECoG samples with and without acute VNS stimulation.

Methods:
Ten 60-second ECoGs each from 22 individuals at 3 epilepsy centers were obtained—5 ECoGs with VNS “off” and 5 ECoGs with VNS “on.” Electrocorticograps containing seizures or loss of telemetry connection artifact were excluded from analysis (total of 169 ECoGs were included). Electrocorticographs were analyzed for differences in spectral content by generating average spectrograms for “on” and “off” states and using a linear mixed-effects model to isolate effects of VNS stimulation.

Results:
Acute VNS stimulation reduced average power in the theta band by 4.9%, beta band by 3.8%, and alpha band by 2.5%. The reduction in theta power reached statistical significance with a P value of <0.05.

Conclusions:
Our results provide evidence that acute VNS stimulation results in desynchronization of specific frequency bands (salient decrease in theta and beta bands, smaller decrease in alpha band) in ECoGs recorded by the RNS device in patients with dual (VNS and RNS) neurostimulators. This finding offers support for desynchronization as a theorized mechanism of action of VNS. Further research may lead to future improved neurostimulator efficacy by informing optimal stimulation programming parameters.
Virtual mindfulness interventions to promote well-being in young adults: A mixed-methods systematic review
Authors: Xu Joy , Jo Helen , Noorbhai Leena , Patel Ami , Li Amy 
Published: April 2021

ABSTRACTBackgroundWith the onset of the COVID-19 pandemic, students have experienced drastic changes in their academic and social lives with ensuing consequences towards their physical and mental well-being. The purpose of this systematic review is to identify virtual mindfulness-based interventions for the well-being of young adults aged 15 to 40 years in developed countries and examine the efficacy of these techniques/exercises.MethodsThis mixed-methods systematic review follows the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines with a registered PROSPERO protocol. With a convergent integrated synthesis approach, IEEE Xplore, PsychInfo, Web of Science and OVID were searched with a predetermined criteria and search strategy employing booleans and filters for peer-reviewed and grey literature. Data screening and extraction were independently performed by two authors, with a third author settling disagreements after reconciliation. Study quality of selected articles was assessed with two independent authors using the Mixed Methods Appraisal Tool (MMAT). Studies were analyzed qualitatively (precluding meta and statistical analysis) due to the heterogeneous study results from diverse study designs in present literature.ResultsCommon mindfulness-based interventions used in the appraised studies included practicing basic mindfulness, Mindfulness-Based Stress Reduction (MBSR) programs, Mindfulness-Based Cognitive Therapy programs (MBCT) and the Learning 2 BREATHE (L2B) program.ConclusionStudies implementing mindfulness interventions demonstrated an overall improvement in well-being. Modified versions of these interventions can be implemented in a virtual context, so young adults can improve their well-being through an accessible format.
How the COVID-19 pandemic is shaping research in Africa: inequalities in scholarly output and collaborations and new opportunities for scientific leadership
Authors: Mbogning Fonkou Maxime Descartes , Bragazzi Nicola Luigi , Tsinda Emmanuel Kagning , Bouba Yagai , Mmbando Gideon Sadikiel , Kong Jude Dzevela 
Published: April 2021

AbstractBackgroundScientometrics enables scholars to assess and visualize emerging research trends and hot-spots in the scientific literature from a quantitative standpoint. In the last decades, Africa has nearly doubled its absolute count of scholarly output, even though its share in global knowledge production has dramatically decreased. This limited contribution of African scholars to the global research output is in part impacted by the availability of adequate infrastructures and research collaborative networks. The still ongoing COVID-19 pandemic has profoundly impacted the way scholarly research is conducted, published and disseminated. However, the COVID-19 related research focus, the scientific productivity and the research collaborative network of African researchers during the ongoing COVID-19 pandemic remain to be elucidated yet.MethodsThis study aimed to clarify the COVID-19 research patterns among African researchers and estimate the strength of collaborations and partnerships between African researchers and scholars from the rest of the world during the COVID-19 pandemic, collecting data from electronic scholarly databases such as Web of Sciences (WoS), PubMed/MEDLINE and African Journals OnLine (AJOL), the largest and prominent platform of African-published scholarly journals.ResultsIn the present bibliometric study, we found that COVID-19 related collaboration patterns varied among African regions, being shaped and driven by historical, social, cultural, linguistic, and even religious determinants. For instance, most of the scholarly partnerships occurred with formerly colonial countries (like European or North-American countries). In other cases, scholarly ties of North African countries were above all with the Kingdom of Saudi Arabia. In terms of amount of publications, South Africa and Egypt were among the most productive countries.DiscussionBibliometrics and, in particular, scientometrics can help scholars identify research areas of particular interest, as well as emerging topics, such as the COVID-19 pandemic. With a specific focus on the still ongoing viral outbreak, they can assist decision- and policy-makers in allocating funding and economic-financial, logistic, organizational, and human resources, based on the specific gaps and needs of a given country or research area.ConclusionsIn conclusion, the ongoing COVID-19 pandemic has exerting a subtle, complex impact on research and publishing patterns in African countries. On the one hand, it has distorted and even amplified existing inequalities and disparities in terms of amount of scholarly output, share of global knowledge, and patterns of collaborations. On the other hand, COVID-19 provided new opportunities for research collaborations.
Machine Learning Approaches for Binary Classification to Discover Liver Diseases using Clinical Data
Authors: Mostafa Fahad B. , Hasan Easin 
Published: April 2021

ABSTRACTFor a medical diagnosis, health professionals use different kinds of pathological ways to make a decision for medical reports in terms of patients’ medical condition. In the modern era, because of the advantage of computers and technologies, one can collect data and visualize many hidden outcomes from them. Statistical machine learning algorithms based on specific problems can assist one to make decisions. Machine learning data driven algorithms can be used to validate existing methods and help researchers to suggest potential new decisions. In this paper, Multiple Imputation by Chained Equations was applied to deal with missing data, and Principal Component Analysis to reduce the dimensionality. To reveal significant findings, data visualizations were implemented. We presented and compared many binary classifier machine learning algorithms (Artificial Neural Network, Random Forest, Support Vector Machine) which were used to classify blood donors and non-blood donors with hepatitis, fibrosis and cirrhosis diseases. From the data published in UCI-MLR, all mentioned techniques were applied to find one better method to classify blood donors and non-blood donors (hepatitis, fibrosis, and cirrhosis) that can help health professionals in a laboratory to make better decisions. Our proposed ML-method showed a better accuracy score (e.g. 98.23% for SVM). Thus, it improved the quality of classification.
Synovial Gene Signatures Associated with the Development of Rheumatoid Arthritis in At Risk Individuals: a Prospective Study
Authors: van Baarsen Lisa G.M. , de Jong Tineke A. , de Hair Maria J.H. , Semmelink Johanna F. , Choi Ivy Y. , Gerlag Danielle M. , Tak Paul P. 
Published: April 2021

AbstractBackgroundPrevious work has shown subtle infiltration of synovial T cells in the absence of overt synovial inflammation in individuals at risk of developing rheumatoid arthritis (RA).ObjectiveTo study the molecular changes in synovium preceding arthritis development in at risk individuals.Materials and methodsWe included sixty-seven individuals with arthralgia who were IgM rheumatoid factor (RF) and/or anti-citrullinated protein antibody (ACPA) positive and without any evidence of arthritis. All individuals underwent mini-arthroscopic synovial tissue sampling of a knee joint at baseline and were followed prospectively. An explorative genome-wide transcriptional profiling study was performed on synovial tissue using Agilent arrays (discovery cohort). Survival analysis was used to identify transcripts associated with arthritis after follow up. Expression levels of differentially expressed genes were validated using quantitative real-time PCR (qPCR). Immunohistochemistry was used to study gene candidates at the protein level in situ.ResultsIn the discovery cohort, 6 of the 13 at risk individuals developed RA after a median follow-up time of 20 months (IQR 2 – 44; pre-RA). The 7 individuals who did not develop RA had a median follow-up time of 85 months (IQR 69 – 86). Using a False Discovery Rate of <5% we found increased expression of 3,151 transcripts correlating with a higher risk of arthritis development, whereas increased expression of 2,437 transcripts correlated with a lower risk. Gene set enrichment analysis revealed that synovial biopsies of pre-RA individuals display higher expression of genes involved in several immune response-related pathways compared with biopsies of individuals who did not develop RA. In contrast, lower expression was observed for genes involved in extracellular matrix receptor interaction, Wnt-mediated signal transduction and lipid metabolism. Two-way hierarchical cluster analysis of 27 genes measured by qPCR classified the synovial biopsies of 61 individuals into two groups, where pre-RA individuals (n=16) showed a preference to cluster together. Synovial tissue from pre-RA individuals were more likely to show podoplanin positive cells and lower lipid staining compared with synovial tissue from individuals who did not develop RA.ConclusionMolecular changes can be detected in synovial tissues before clinical onset of arthritis. Alterations in the immune response genes and lipid metabolism are associated with development of arthritis.
Germline loss-of-function variants in the base-excision repair geneMBD4cause a Mendelian recessive syndrome of adenomatous colorectal polyposis and acute myeloid leukaemia
Authors: Palles Claire , Chew Edward , Grolleman Judith E. , Galavotti Sara , Flensburg Christoffer , Jansen Erik A.M. , Curley Helen , Chegwidden Laura , Barnes Edward Arbe , Bajel Ashish , Sherwood Kitty , Martin Lynn , Thomas Huw , Georgiou Demetra , Fostira Florentia , Goldberg Yael , Adams David J. , van der Biezen Simone A.M. , Christie Michael , Clendenning Mark , Deltas Constantinos , Dimovski Aleksandar J. , Dymerska Dagmara , Lubinski Jan , Mahmood Khalid , van der Post Rachel S. , Sanders Mathijs , Weitz Jürgen , Taylor Jenny C. , Turnbull Clare , Vreede Lilian , van Wezel Tom , Whalley Celina , Pac Claudia Arnedo , Caravagna Gulio , Cross William , Chubb Daniel , Frangou Anna , Gruber Andreas , Kinnersley Ben , Noyvert Boris , Church David , Graham Trevor , Houlston Richard , Lopez-Bigas Nuria , Sottoriva Andrea , Wedge David ,   Genomics England Research Consortium,   The CORGI Consortium,   WGS500 Consortium, Jenkins Mark A. , Kuiper Roland P. , Roberts Andrew W. , Ligtenberg Marjolijn J.L. , Hoogerbrugge Nicoline , Koelzer Viktor H. , Rivas Andres Dacal , Winship Ingrid M. , Ponte Clara Ruiz , Buchanan Daniel D. , Tomlinson Ian P.M. , Majewski Ian J. , de Voer Richarda M. 
Published: April 2021

ABSTRACTInherited defects in base-excision repair (BER) predispose to adenomatous polyposis and colorectal cancer (CRC), yet our understanding of this important DNA repair pathway remains incomplete. By combining detailed clinical, histological and molecular profiling, we reveal biallelic germline loss-of-function (LOF) variants in the BER geneMBD4to predispose to adenomatous polyposis and –uniquely amongst CRC predisposition syndromes– to myeloid neoplasms. Neoplasms from MBD4-deficient patients almost exclusively accumulate somatic CpG>TpG mutations, resembling mutational signature SBS1. MBD4-deficient adenomas harbour mutations in known CRC driver genes, althoughAMER1mutations were more common andKRASmutations less frequent. We did not find an increased risk for colorectal tumours in individuals with a monoallelicMBD4LOF variant. We suggest that this condition should be termedMBD4-associated neoplasia syndrome (MANS) and thatMBD4is included in testing for the genetic diagnosis of polyposis and/or early-onset AML.
The Boundary-ExpressedEPIDERMAL PATTERNING FACTOR-LIKE2Gene Encoding a Signaling Peptide Promotes Cotyledon Growth duringArabidopsis thalianaEmbryogenesis
Authors: Fujihara Rina , Uchida Naoyuki , Tameshige Toshiaki , Kawamoto Nozomi , Hotokezaka Yugo , Higaki Takumi , Simon Rüdiger , Torii Keiko U , Tasaka Masao , Aida Mitsuhiro 
Published: April 2021

AbstractThe shoot organ boundaries have important roles in plant growth and morphogenesis. It has been reported that a gene encoding a cysteine-rich secreted peptide of the EPIDERMAL PATTERNING FACTOR-LIKE (EPFL) family,EPFL2, is expressed in the boundary domain between the two cotyledon primordia ofArabidopsis thalianaembryo. However, its developmental functions remain unknown. This study aimed to analyze the role ofEPFL2during embryogenesis. We found that cotyledon growth was reduced in its loss-of-function mutants, and this phenotype was associated with the reduction of auxin response peaks at the tips of the primordia. The reduced cotyledon size of the mutant embryo recovered in germinating seedlings, indicating the presence of a factor that acted redundantly withEPFL2to promote cotyledon growth in late embryogenesis. Our analysis indicates that the boundary domain between the cotyledon primordia acts as a signaling center that organizes auxin response peaks and promotes cotyledon growth.
Remote working, management control changes and employee responses during the COVID-19 crisis
Authors: Delfino Gianluca F , van der Kolk Berend 
Published: April 2021

PurposeThe authors examine the impact of the sudden shift to remote working, triggered by the coronavirus disease 2019 (COVID-19) crisis, on management control (MC) practices in professional service firms (PSFs). In addition, employee responses to these changes are explored.Design/methodology/approachThe authors carried out a field study of MC changes in PSFs in Italy, the first country in Europe that was severely impacted by COVID-19. Interviews with PSF employees form the primary data source. Pattern matching was used to identify similarities and differences and investigate how employees respond to the MC changes.FindingsAs a response to the shift to remote working, managers at PSFs made various MC-related changes. For instance, they increased the number of online meetings and made use of technologies to monitor employees from a distance. Employees reacted to this by engaging in “voluntary visibilizing practices”, i.e. by trying to make sure they got noted by their superiors, for instance by doing overtime. In addition, collected evidence suggests increased stress levels among employees, changes to employee autonomy, changed perceptions of hierarchies and a weakened sense of relatedness with others in the organization.Originality/valueThis is one of the first studies to examine the impact of the sudden shift to remote working on MC. In addition, this paper contributes by exploring employee responses to the MC-related changes. The findings add to the growing literature on MC and motivation, and the notion of voluntary visibilizing practices is mobilized to warn against over-commitment and self-exploitation.
Until you have something to lose! Loss aversion and two-factor authentication adoption
Authors: Pratama Ahmad R. , Firmansyah Firman M. 
Published: April 2021

PurposeIn this study, the authors seek to understand factors that naturally influence users to adopt two-factor authentication (2FA) without even trying to intervene by investigating factors within individuals that may influence their decision to adopt 2FA by themselves.Design/methodology/approachA total of 1,852 individuals from all 34 provinces in Indonesia participated in this study by filling out online questionnaires. The authors discussed the results from statistical analysis further through the lens of the loss aversion theory.FindingsThe authors found that loss aversion, represented by higher income that translates to greater potential pain caused by losing things to be the most significant demographic factor behind 2FA adoption. On the contrary, those with a low-income background, even if they have some college degree, are more likely to skip 2FA despite their awareness of this technology. The authors also found that the older generation, particularly females, to be among the most vulnerable groups when it comes to authentication-based cyber threats as they are much less likely to adopt 2FA, or even to be aware of its existence in the first place.Originality/valueAuthentication is one of the most important topics in cybersecurity that is related to human-computer interaction. While 2FA increases the security level of authentication methods, it also requires extra efforts that can translate to some level of inconvenience on the user's end. By identifying the associated factors from the user's ends, a necessary intervention can be made so that more users are willing to jump on the 2FA adopters' train.
Supply chain resilience: mapping the knowledge domains through a bibliometric approach
Authors: Ekanayake E.M.A.C. , Shen Geoffrey Qiping , Kumaraswamy Mohan 
Published: April 2021

PurposeThis paper aims to review the state-of-the-art of literature of supply chain resilience (SCR) and to map the SCR domain, so as to provide a launchpad for further knowledge development and dissemination.Design/methodology/approachCiteSpace as a bibliometric analysis software was used to systematically, comprehensively and accurately review the SCR-related literature and to then develop an SCR research map.FindingsThe results revealed the existing SCR publication base, domains, highly contributed publications, research hotspots, key milestones of SCR research development and a dynamic platform to integrate future research and development of SCR.Originality/valueThe scientific contribution to SCR knowledge is an accurate and quantitative SCR research map, including the related SCR publication base, domains, pillars, hotspots, evolution and future trends. The methodology and the findings can be generalised to many other fields. Besides, the proposed SCR research map could be frequently updated by injecting future findings from similar studies to fill any residual or newly emerging research gaps. Moreover, the results could inspire further new knowledge creation in the SCR domain, identify future research demands in this field and ultimately boost the performance of global SCs by triggering smart and sustainable practices.
Multi-party game and simulation in the withdrawal of rural homestead: evidence from China
Authors: Song Lei , Lyu Ping , Cao Yingui 
Published: April 2021

PurposeThe purpose of this study was to analyze the interest conflicts and strategy evolution process of various stakeholders in the process of homestead withdrawal, to reveal which key factors can balance the interests of all parties.Design/methodology/approachThe authors developed an evolutionary game theoretical framework for homestead withdrawal in Yujiang District, Jiangxi Province, China. The authors compared the dynamic process of strategy change in different situations based on system dynamics.FindingsCompared with indirect external factors, direct economic factors, such as increasing compensation standards or increasing fines, are more likely to encourage peasants to withdraw from their homesteads. The dynamic subsidy strategy can increase the probability of peasants withdrawing from their homestead. Additionally, awarding officials with promotions can effectively encourage local governments during the process.Originality/valuePrevious studies have conceptualized farmers' willingness to withdraw from their homestead as a static process, ignoring the underlying dynamism. This paper analyzes the game mechanism among the stakeholders of the homestead withdrawal process from a dynamic perspective, to provide efficient suggestions regarding policymaking for homestead withdrawal.