bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suprascapular nerve block and axillary nerve block versus interscalene nerve block for arthroscopic shoulder surgery
Authors: Sun Changjiao , Zhang Xiaofei , Ji Xiaolin , Yu Peng , Cai Xu , Yang Huadong 
Published: December 2021

Abstract

Background:
The interscalene brachial plexus block (ISB) is a commonly used nerve block technique for postoperative analgesia in patients undergoing shoulder arthroscopy surgery; however, it is associated with potentially serious complications. The use of suprascapular nerve block (SSNB) and axillary Nerve Block (ANB) has been reported as an alternative nerve block with fewer reported side effects for shoulder arthroscopy. This review aimed to compare the impact of SSNB and ANB with ISB during shoulder arthroscopy surgery.

Methods:
A meta-analysis was conducted to identify relevant randomized or quasirandomized controlled trials involving SSNB and ISB during shoulder arthroscopy surgery. We searched Web of Science, PubMed, Embase, Cochrane Controlled Trials Register, Cochrane Library, Highwire, CNKI, and Wanfang database from 2010 through August 2021.

Results:
We identified 641 patients assessed in 10 randomized or quasirandomized controlled trials. Compared with the ISB group, the SSNB+ANB group had higher visual analog scale or numerical rating scale in PACU (P = .03), 4 hour (P = .001),6 hour after the operation (P = .002), and lower incidence of complications such as Numb/Tingling (P = .001), Weakness (P <.00001), Horner syndrome (P = .001) and Subjective dyspnea (P = .002). No significant difference was found for visual analog scale or numerical rating scale 8 hour (P = .71),12 hour (P = .17), 16 hour (P = .38),1day after operation (P = .11), patient satisfaction (P = .38) and incidence of complications such as hoarseness (P = .07) and nausea/vomiting (P = .41) between 2 groups.

Conclusion:
Our high-level evidence has established SSNB+ ANB as an effective and safe analgesic technique and a clinically attractive alternative to interscalene block during arthroscopic shoulder surgery, especially for severe chronic obstructive pulmonary disease, obstructive sleep apnea, and morbid obesity. Given our meta-analysis's relevant possible biases, we required more adequately powered and better-designed randomized controlled trial studies with long-term follow-up to reach a firmer conclusion.
A novel negative pressure wound therapy (NPWT) monitoring system for postoperative flap management
Authors: Kim Tae Hyung , Park Jun Ho 
Published: December 2021

Abstract
Various types of flaps are widely utilized as reconstructive options for patients with soft tissue defects. However, the postoperative monitoring of the flap requires a large amount of time and effort. The aim of this study was to evaluate the efficacy and safety of this novel monitoring procedure using negative pressure wound therapy (NPWT) immediately after the flap operations.
A retrospective analysis was performed on patients who underwent free flaps and perforator flaps from March 2019 to December 2020. The flaps were managed by either novel NPWT method or conventional dressing. Among NPWT group, computed tomography angiography was performed in randomly selected 5 flaps on the third postoperative day for evaluation of pedicle compression. Statistical analysis was performed between the 2 groups.
A total of 54 flaps were included in this study. Twenty seven flaps were managed using novel NPWT method and 27 flaps were managed using conventional dressing. There was no statistically significant difference in flap survival rates between the 2 groups (P = .91). The patency of flap pedicles in the NPWT group was confirmed by comparing the computed tomography angiography findings. The estimated total flap monitoring time and cost for 5 days was significantly decreased by the application of the novel NPWT monitoring system.
Through the application of the novel postoperative monitoring system using NPWT, there is efficient evaluation of the flap. Furthermore, safe flap monitoring is possible with the reduced risk of infection by the avoidance of multiple manual dressing performed in the conventional method.
Clinical and endoscopic characteristics of acute esophageal necrosis and severe reflux esophagitis
Authors: Okamoto Takeshi , Suzuki Hidekazu , Fukuda Katsuyuki 
Published: December 2021

Abstract
The similarities and differences between acute esophageal necrosis and severe reflux esophagitis have not been elucidated. We compared Los Angeles classification Grade C reflux esophagitis, Grade D reflux esophagitis, and acute esophageal necrosis to consider the similarities and differences between acute esophageal necrosis and severe reflux esophagitis.
We retrospectively reviewed records of patients who underwent esophagogastroduodenoscopy at a tertiary referral center from January 2012 to December 2019. Data on patients diagnosed as Grade C reflux, Grade D reflux, or acute esophageal necrosis for the first time were extracted for analysis.
A total of 213 patients were enrolled in the study, composed of 130 Grade C reflux, 74 Grade D reflux, and 9 acute esophageal necrosis patients. Compared to Grade C reflux patients, Grade D reflux and acute esophageal necrosis patients were more likely to be transfused (P = .013 and P = .011, respectively), to have duodenal ulcers (P = .025 and P = .049, respectively), and to have psychiatric illnesses (P = .022 and P = .018, respectively). Compared to both Grade C and D reflux, acute esophageal necrosis patients were more likely to present with shock (P = .003 and P < .001, respectively), have type 1 diabetes (P = .030 and P = .004, respectively), and present in winter (P < .001 and P < .001, respectively). Significant step-wise differences (Grade C < Grade D < acute esophageal necrosis) were observed in the need for admission (P < .001 and P = .009), coffee ground emesis (P < .001 and P = .022), and stigmata of hemorrhage on endoscopy (P = .002 and P < .001). Admission (P = .003) and coffee ground emesis (P = .003) independently predicted either Grade D reflux or acute esophageal necrosis over Grade C reflux on multivariate analysis.
Shock, type 1 diabetes, and winter may predict acute esophageal necrosis, while the need for admission and coffee ground emesis may predict Grade D reflux or acute esophageal necrosis.
Multi-center survey on the training status of staff working in pharmacy intravenous admixture services (PIVAS) in mainland China
Authors: Ni Xiaofeng , Yang Chunsong , Mi Wenjie , Zhang Lingli 
Published: December 2021

Abstract
The technical level and comprehensive quality of pharmacy intravenous admixture services (PIVAS) staff are central to ensure the safety and effectiveness of intravenous infusions. However, these aspects are lacking in traditional pharmacy education. This study aimed to investigate the training status of staff working in PIVAS and explore factors that affected training status, which might contribute to the establishment of a comprehensive, standardized training system.
A multi-center cross-sectional survey was conducted via a WeChat Group targeting PIVAS staff in hospitals to investigate the differences of current training status between different regions, hospital levels, genders, job titles, educational degrees, employment types, and working years.
In total, 501 participants completed the questionnaires. The main contents of training for PIVAS staff included: professional theoretical knowledge (99.40%, 498/501), practical operation abilities (97.01%, 486/501), pre-job training (92.61%, 464/501), and standard operating procedures (90.22%, 452/501). The most common frequency of staff training was 1–2 times a month (51.9%, 260/501). Overall, 56.5% (283/501) of participants thought staff training was sufficient and 60.1% (301/501) of participants thought PIVAS attached importance to staff training. However, only 45.7% (229/501) of the participants were satisfied with the training modes.
The contents of training for PIVAS staff in mainland China were relatively rich, but the aspects of management tools, comprehensive ability development, and career development planning tend to be relatively weak. It is necessary to develop training standards for PIVAS staff to improve employee capabilities and job satisfaction.
Effect of Buzhong Yiqi decoction on anti-acetylcholine receptor antibody and clinical status in juvenile ocular myasthenia gravis
Authors: Li Jiaduo , Qi Guoyan , Liu Yaling 
Published: December 2021

Abstract
Ocular myasthenia gravis (MG) is the mainly widespread type of MG among juveniles. Buzhong Yiqi decoction (BZ) is a well-known traditional Chinese medicine prescription for treating MG. It has rarely been discussed whether the concentration of anti-acetylcholine receptor (AChR) antibodies is related to the clinical status of juvenile ocular myasthenia gravis (JOMG) treated with BZ.
The patients with JOMG who had more than once AChR-antibody (ab) test and treated with BZ were retrospectively identified from June 2013 to January 2020 in the first hospital in Shijiazhuang. The presence or absence of ocular symptoms was used to grade the effectiveness of treatment. Generalized estimating equations logistic regression analysis was used to evaluate the effect of AChR ab concentration on the clinical status of MG.
A total of 549 AChR-ab tests were performed in 135 patients, and the corresponding clinical status was recorded. One hundred two patients received treatment with BZ only and 33 combined with immunosuppressive drugs. In the group receiving only BZ treatment, the anti-acetylcholine receptor ab concentration was positively correlated with the clinical score after treatment.
The results suggest that BZ could affect the AChR-ab. Repeated AChR-ab assays can provide information about the clinical status. For JOMG patients who only receive Buzhong Yiqi Decoction treatment, this can support treatment decisions.
Evaluation of the effectiveness and safety of acupuncture in the treatment of premature ventricular contractions
Authors: Li Hongyu , Liu Aidong , Liu Zhenhua , Cheng Guangyu , Cui Junfeng , Li Shuangdi , Li Pengfei , Xin Yuning , Liu Yinghui 
Published: December 2021

Abstract

Background:
Premature ventricular contractions are the most common type of arrhythmia. The clinical symptoms are mainly palpitations. In severe cases, syncope, angina pectoris and heart failure may occur, which seriously affect people's lives and ability to work. Antiarrhythmic drugs have many side effects and should not be taken for long periods. Acupuncture has a significant effect on the treatment of premature ventricular contractions. Therefore, to evaluate the effectiveness and safety of acupuncture in the treatment of premature ventricular contractions, we conducted this study, with the goal of providing a scientific methodology for this alternative treatment.

Methods:
We searched PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, China Science Journal Database, and China Biomedical Literature Database. We selected all randomized clinical trials related to the use of acupuncture in the treatment of premature ventricular contractions published on or before October 10, 2021, and we will conduct literature screening and data extraction based on specific inclusion and exclusion criteria. We will use the bias risk assessment tool from the Cochrane Systematic Review Manual to evaluate the quality of the research selected for inclusion in our study. RevMan5.3 software will be used to perform statistical analysis on the data.

Results:
The results of this study will provide evidence for the effectiveness and safety of acupuncture in the treatment of premature ventricular contractions.

Conclusion:
The purpose of this study is to explore the efficacy of acupuncture in the treatment of patients with premature ventricular contractions and to provide an effective reference for clinicians and patients on its use.

INPLASY registration number:
INPLASY2021100040.
The effect of ultrasound-guided low serratus anterior plane block on laparoscopic cholecystectomy postoperative analgesia
Authors: Wu Yu , Yang Weicai , Cai Zenghua , Zhang Zaiwang 
Published: December 2021

Abstract

Background:
Anterior serratus plane block for analgesia in many procedures, but there have been no reports of analgesia undergoing laparoscopic cholecystectomy (LC). We investigated the effects of ultrasonic-guided low serratory anterior block on patients undergoing LC.

Methods:
One hundred patients who undergo LC were selected and randomly divided into 2 groups: Patients in group C with routine general anesthesia and patients in group S treat low anterior serratus block combined with general anesthesia. The serratus anterior block was performed at the T8 to T9 point after anesthesia induction, before cutting leather (T0), stamp card placement (T1), 2 groups of patients’ heart rate (HR), blood pressure were recorded, at the same time dosage of analgesic drugs and postoperative 0.5, 6, 12, 24 hours when resting visual analogue scale (VAS) scores were recorded in 2 groups of patients.

Results:
The T0 point, patients’ HR, blood pressure had significant difference (P > .05), the T1 point, patients’ HR, mean arterial pressure in group S lower than group C (P < .05), the amount of intra-operative propofol and remifentanil, patients in group S were less than in group C (P < .05), and resting VAS pain score at the 0.5, 6, 12 hours after operation patients in group S were lower than group C also (P < .05), resting VAS pain had no significant difference at postoperative 24 hours between 2 groups (P > .05).

Conclusion:
Low serratus anterior plane block in LC can provide safe and effective analgesia for patients.
Platelet to lymphocyte ratio is associated with tumor localization and outcomes in metastatic colorectal cancer
Authors: Acikgoz Ozgur , Cakan Burcin , Demir Tarik , Bilici Ahmet , Oven Bala Basak , Hamdard Jamshid , Olmuscelik Oktay , Olmez Omer Fatih , Seker Mesut , Yildiz Ozcan 
Published: December 2021

Abstract
The aim of this study was to investigate the predictive and prognostic value of PLR, and the relationship between PLR and tumor localization.
A total of 229 patients with de-novo metastatic CRC were retrospectively analyzed. The cutoff value for PLR was defined by the receiver operating characteristic (ROC) curve analysis and threshold value of 196.5 as best cut-off value was found.
The higher rate of BRAF mutation was significantly detected for patients with PLRhigh (> 196.5) compared to those with PLRlow (≤196.5) (P = .001). PLR was significantly higher in tumors located on the right colon (P = .012). PLR, tumor localization, the presence of surgery for primary tumor, the presence of curative surgery, the presence of metastasectomy for progression-free survival (PFS) and PLR, gender, BRAF mutation, tumor localization, the presence of surgery for primary tumor, the presence of metastasectomy for overall survival (OS) were found to be prognostic factors by univariate analysis. Multivariate analysis showed that PLR, the presence of curative surgery and the presence of metastasectomy for both PFS and OS were found to be independent prognostic factors. Moreover, a logistic regression analysis indicated that PLR and tumor localization were found to be an independent factors for predicting response to systemic treatment (P < .001 and P = .023 respectively).
Our results showed that pretreatment PLR was readily feasible and simple biomarker predicting response to treatment and survival, in addition it was significantly associated with tumor localization.
Successful management of severe allergic reactions to platelet transfusion with omalizumab
Authors: Choi Yeonjoo , Byun Ja Min , Kim Inho , Park Jin Hyun , Kim Ki Hwan , Kim Jin-Soo , Choi In Sil , Yang Min-Suk , Park Hyunkyung 
Published: December 2021

Abstract

Rationale:
An allergic transfusion reaction is a common side effect of transfusions of red blood cells. Using washed red blood cells is the most effective method for preventing such a reaction. However, the availability of other washed transfusion components, including platelets, is limited.

Patient concerns:
A 69-year-old patient with acute myeloid leukemia progressed from myelodysplastic syndrome and was treated with azacitidine. She experienced a minor reaction to platelet transfusion that initially responded to the administration of corticosteroids and antihistamines. However, she worsened even after subsequent preventive treatments and was referred to the emergency department due to anaphylaxis. The patient developed hypotension, chest pain, and dyspnea 10 minutes after the initiation of platelet transfusion.

Diagnoses:
She was diagnosed with platelet-induced anaphylaxis.

Interventions:
In an attempt to prevent anaphylaxis, 150 mg of omalizumab was prescribed 1 week prior to transfusion. However, she experienced anaphylaxis again and was administered intramuscular epinephrine. For the following transfusion, we treated her with a 300 mg dose of omalizumab 24 hours before the transfusion.

Outcomes:
She tolerated well and continued to receive further chemotherapy and platelet transfusion with premedication.

Lessons:
This case suggests that omalizumab is a good candidate for the management of severe allergic transfusion reactions.
Does the COVID-19 pandemic period itself increases early mortality rates of elderly patients with hip fractures in Turkey?
Authors: Bilgetekin Yenel Gürkan , Öztürk Alper , Yüksel Sinal , Kunu Orhan , Atilla Halis Atil , Ersan Önder 
Published: December 2021

Abstract
Hip fractures are common in elderly patients and prone to serious morbidity and mortality particularly when the treatment is delayed. The objective of this study was to evaluate the effect Coronavirus disease of 2019 (COVID-19) pandemic on the early mortality rates of geriatric patients with hip fractures.
281 patients who were followed and operated on with the diagnosis of proximal femur fracture were included in this retrospective study. Patients were divided into 2 groups, that is, 180 patients presenting between March and June 2018 to 2019 (prepandemic period) and 101 patients presenting between March and June 2020 (pandemic period). Age, sex, type of fracture, time from fracture to presentation to hospital, comorbidities, time from admission to operation, length of intensive care unit stay, length of hospital stay, and mortality rates were retrieved from hospital records and evaluated.
While there was no significant difference in terms of age, sex, type of fracture, in-hospital mortality, 30-day mortality, time to surgery, Charlson comorbidity index and length of intensive care unit stay through pandemic and prepandemic period (P > .05), significant differences were observed in terms of length of hospital stay, time to admission, refusal of hospitalization and attending outpatient visits regularly (P < .05). Attending outpatient visits and the length of hospital stay were the main significant differences in multivariate analysis.
The early mortality rates in patients with hip fractures were similar during the pandemic period to before in Turkey. However, the length of hospital stay was prolonged and more patients refused the treatment and fewer of them attended regular outpatient controls in the pandemic.
Effect of Vergence Facility Testing on Horizontal Fusional Reserves
Authors: Askarizadeh Farshad , Heirani Mohsen , Khorrami-Nejad Masoud , Khabazkhoob Mehdi , Narooie-Noori Foroozan 
Published: December 2021

SIGNIFICANCE
The effect of vergence adaptation on test sequences should be considered in clinical practice.

PURPOSE
This study aimed to compare the effect of vergence adaptation after different vergence facility (VF) testing methods on following horizontal fusional reserve measurement at near.

METHODS
This cross-sectional study was performed on 50 healthy subjects with a mean ± standard deviation age of 21.18 ± 1.41 years. The baseline horizontal fusional reserves were measured using base-in (BI) and base-out (BO) prisms (∆) at near. Then, VF was measured using 3∆BI/12∆BI flip prism at near, and then the measurement of fusional reserves was repeated. In the next step, fusional reserves were measured after VF testing using 8∆BI/8∆BO flip prism. The values of fusional reserves were compared with their baseline findings.

RESULTS
The results of negative fusional reserves after VF measurement using the 3∆BI/12∆BO prisms were significantly lower than the baseline values (blur [P = .03], break [P = .03], and recovery [P = .03]). There were no significant differences between the values of fusional reserves before and after VF testing using the 8∆BI/8∆BO prisms (P > .05). No correlation was observed between fusional reserves and VF responses (P > .05); however, the results revealed a positive correlation between the values of fusional reserves before and after VF testing using both methods (all P < .05). There was no significant difference in VF findings between the methods (P = .23).

CONCLUSIONS
The measurements of horizontal fusional reserves followed by VF testing were not affected except for the responses of negative fusional reserves, which decreased after VF determination using the 3∆BI/12∆BO method. Although the vergence adaptation does not seem clinically significant, it is recommended to evaluate horizontal fusional reserves before VF measurement or long-enough time after VF testing for the vergence system to return to its nonadapted state.
Feasibility of Implementing Recommendations to Reduce Fall Risk in Older People: A Delphi Study
Authors: Ho Kam Chun , Elliott David , Charlesworth Emily , Gyawali Rajendra , Keay Lisa 
Published: December 2021

SIGNIFICANCE
This study provides guidance for the implementation of recommendations for falls prevention in optometry practice, through synthesis with the optometrists' viewpoint as a major stakeholder. Educators and clinicians can adopt the revised recommendations and associated implementation strategies in this research for successful integration into optometric practice.

PURPOSE
Recommendations for optometrists to help prevent falls in older patients were published in 2019 by Optometry Australia. This study used the Delphi technique to gain perspectives on the feasibility of implementing the recommendations in optometric practice.

METHODS
A Delphi consensus process consisted of two rounds of anonymous questionnaires administered between October 2019 and February 2020. A panel of 12 optometrists scored and commented on the importance and feasibility of 28 recommendations based on a published evidence synthesis by Optometry Australia and a pilot Delphi round. Panelists were invited if they had at least 5-year experience in optometry practice and were involved in post-cataract surgery refractive management regularly in the past 12 months.

RESULTS
Twenty-four recommendations reached consensus after the Delphi process. Recommendations that reached consensus but had low uptake in the panelists' practices were history taking about risk of falls and provision of advice to patients to seek professional home modification. Four recommendations did not reach consensus because they were perceived to be too prescriptive and less feasible to execute in real-world settings. To improve the compliance of patients to recommendations to reduce the risk of falls, panelists recommended involving patients in decision making and practice staff should be involved in falls prevention messaging.

CONCLUSIONS
The Delphi panel supported the feasibility of most of the recommendations in optometric practice and provided suggestions to improve their implementation. Further research is needed to evaluate the implementation and benefits of these recommendations, designed to make optometric practice more effective in preventing patient falls.