bluuebunny/crossref_metadata_2025_split huggingface dataset:
CircRNAs in Lung Adenocarcinoma: Diagnosis and Therapy
Authors: Wang Yanhua , Su Lijia , Zhao Jinying , Su Huahua , Huang Wenfeng , Jiang Xuemei , Gao Shiyao 
Published: December 2021

Abstract:
Lung adenocarcinoma (LUAD) is the common histological subtype of non-small-cell
lung carcinoma (NSCLC). Circular RNAs (circRNAs) represent a new class of non-coding RNAs
(ncRNAs) involved in the development of cancer. Accumulating evidence indicated that a large
number of circular RNAs were found to be involved in many biological processes, including tumor
initiation, proliferation and progression. These circRNAs present great potentials as new biomarkers
and vital targets for disease diagnosis and prognosis. In this review, we mainly focus on the differentially
expressed circRNAs and their functions in the pathogenesis of LUAD, which makes it
possible for the utility of circRNAs as novel biomarkers for early diagnosis and therapy. Especially,
it is helpful to develop circRNAs as crucial therapeutic targets, thus providing a promising
biomedical application in the field of cancer gene therapy.
vHTS, 3-D Pharmacophore, QSAR and Molecular Docking Studies for
the Identification of Phyto-derived ATP-Competitive Inhibitors of the
BCR-ABL Kinase Domain
Authors: Oyeneyin Oluwatoba Emmanuel , Metibemu Damilohun Samuel , Metibemu Ayorinde Omolara , Adeniran Olawole Yakubu , Omotuyi Idowu Olaposi 
Published: December 2021

Background:
Chronic myelogenous leukaemia (CML) constitutes about 15 % of adult leukaemia
and is characterized by the overproduction of immature myeloid cells.

Methods:
In this study, a virtual high throughput screening (vHTS) technique was employed to screen
a library of phytochemicals of reported plants having anticancer activity. A docking score of -10
kcalmol-1 was used as the cut-off for the selection of phyto-compounds for pharmacophore-based virtual
screening. Statistically robust and thoroughly validated QSAR model (R = 0.914, R2 = 0.836, Adjusted
R2 = 0.764, LOO-CV= 0.6680) was derived for the inhibition of BCR-ABL kinase domain.

Results:
The virtual screening, pharmacophore screening, QSAR model and molecular docking techniques
applied herein revealed ellagic acid, a polyphenolic compound, as a potential competitive inhibitor
of the BCR-ABL kinase domain. Ellagic acid binds to the inactive ABL state and forms similar
interactions with key residues within the BCR-ABL Kinase domain as obtained in ponatinib (having
inhibitory effects on the ABL thr-315I mutant). It forms hydrogen bond interaction with thr-315 residue
(the gatekeeper residue). It is not likely to be prone to the various mutations associated with nilotinib
because of its small size.

Conclusion:
The procedure of VHTs, Pharmacophore, QSAR, and molecular docking applied in this
study could help in detecting more anti-CML compounds.
Automatic Evaluation of Histological Prognostic Factors Using Two Consecutive Convolutional Neural Networks on Kidney Samples
Authors: Marechal Elise , Jaugey Adrien , Tarris Georges , Paindavoine Michel , Seibel Jean , Martin Laurent , Funes de la Vega Mathilde , Crepin Thomas , Ducloux Didier , Zanetta Gilbert , Felix Sophie , Bonnot Pierre Henri , Bardet Florian , Cormier Luc , Rebibou Jean-Michel , Legendre Mathieu 
Published: December 2021

Background and objectives
The prognosis of patients undergoing kidney tumor resection or kidney donation is linked to many histologic criteria. These criteria notably include glomerular density, glomerular volume, vascular luminal stenosis, and severity of interstitial fibrosis/tubular atrophy. Automated measurements through a deep-learning approach could save time and provide more precise data. This work aimed to develop a free tool to automatically obtain kidney histologic prognostic features.

Design, setting, participants, & measurements
In total, 241 samples of healthy kidney tissue were split into three independent cohorts. The “Training” cohort (n=65) was used to train two convolutional neural networks: one to detect the cortex and a second to segment the kidney structures. The “Test” cohort (n=50) assessed their performance by comparing manually outlined regions of interest to predicted ones. The “Application” cohort (n=126) compared prognostic histologic data obtained manually or through the algorithm on the basis of the combination of the two convolutional neural networks.

Results
In the Test cohort, the networks isolated the cortex and segmented the elements of interest with good performances (>90% of the cortex, healthy tubules, glomeruli, and even globally sclerotic glomeruli were detected). In the Application cohort, the expected and predicted prognostic data were significantly correlated. The correlation coefficients r were 0.85 for glomerular volume, 0.51 for glomerular density, 0.75 for interstitial fibrosis, 0.71 for tubular atrophy, and 0.73 for vascular intimal thickness, respectively. The algorithm had a good ability to predict significant (>25%) tubular atrophy and interstitial fibrosis level (receiver operator characteristic curve with an area under the curve, 0.92 and 0.91, respectively) or a significant vascular luminal stenosis (>50%) (area under the curve, 0.85).

Conclusion
This freely available tool enables the automated segmentation of kidney tissue to obtain prognostic histologic data in a fast, objective, reliable, and reproducible way.
Prácticas culturales inmateriales en tiempos de coronavirus. Cambios en las modalidades de la ronda del mate y su consumo
Authors: Levrand Norma Elizabeth , Tessio Conca Silvia , Metivié Mariángeles , Staffolani Claudio , Alcaino Lucio Gonzalo 
Published: December 2021

La pandemia del COVID-19 puso en crisis los parámetros de la vida en su conjunto. En ese contexto, definido como un ‘hecho social total’, ciertas prácticas sociales, como el cebado del mate (infusión de carácter comunitario de numerosas zonas de Argentina y la región) han sido puestas en observación respecto a su inocuidad. Estas restricciones son percibidas y reinterpretadas en formas diversas por la comunidad, y aunque los cambios culturales en general son lentos, las limitaciones a las actividades sociales y comunitarias que proponen los protocolos sanitarios implementados por el COVID-19 podrían generar una resignificación en la práctica del matear y así introducir nuevas interpretaciones respecto a la práctica tradicional. El objetivo de este trabajo es describir los cambios que las medidas de aislamiento social y prevención del virus han generado en la ronda del mate a partir de un análisis comparado de las modificaciones que se han producido en la práctica en las últimas décadas. La metodología se basa en el análisis documental y los resultados parciales de una encuesta virtual de carácter exploratorio llevada a cabo en el período de ASPO. Resultados: La pandemia produjo una alteración en todos los órdenes de la vida, como hecho social total impactó también sobre esta práctica. Los resultados preliminares de la encuesta virtual indican que el 96% continua con el hábito, sin embargo se han incorporado otras infusiones a la dieta. Un cambio fundamental se da en el hábito de compartir la infusión: antes de la pandemia el 96% de quienes tomaban la infusión compartían, durante el aislamiento este porcentaje bajó al 71%. El 66% de los encuestados reconoce el consejo sanitario de no compartir el mate. Sin embargo, entre los consultados el 50% volvería a los hábitos tradicionales de compartir el mate finalizada la pandemia.
Siguiendo los criterios que propone la Convención para la Salvaguardia del Patrimonio Cultural Inmaterial (UNESCO) se propone un ejercicio reflexivo y de posterior acción que podría aportar a salvaguardar una práctica que es parte de la identidad de Argentina y la región, puesta en entredicho como hecho social total en el contexto de pandemia por el COVID-19.
Exercise Training in Duchenne Muscular Dystrophy: A Systematic Review and Meta-Analysis
Authors: Hammer Stian , Toussaint Michel , Vollsæter Maria , Nesbjørg Tvedt Marianne , Drange Røksund Ola , Reychler Gregory , Lund Hans , Andersen Tiina 
Published: December 2021

Objective: To evaluate the effects and safety of exercise training, and to determine the optimal [AQ7] exercise training intervention for people with Duchenne muscular dystrophy. Exercise training was compared with no training, placebo or alternative exercise training. Primary outcomes were functioning and health-related quality of life. Secondary outcomes were muscular strength, endurance and lung function.
Data sources: A systematic literature search was conducted in Medline, EMBASE, CINAHL, Cochrane Central, PEDro and Scopus.
Study selection and data extraction: Screening, data extraction, risk of bias and quality assessment were carried out. Risk of bias was assessed using the Cochrane Collaborations risk of bias tools. The certainty of evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation.
Data synthesis: Twelve studies with 282 participants were included. A narrative synthesis showed limited or no improvements in functioning compared with controls. Health-related quality of life was assessed in only 1 study. A meta-analysis showed a significant difference in muscular strength and endurance in favour of exercise training compared with no training and placebo. However, the certainty of evidence was very low.
Conclusion: Exercise training may be beneficial in Duchenne muscular dystrophy, but the evidence remains uncertain. Further research is needed on exercise training to promote functioning and health-related quality of life in Duchenne muscular dystrophy.
Intrinsic Atopic Dermatitis: Titration of Precipitins in the Screening of Food Allergens for Prescription of Elimination Diets and Desensitization Strategies
Authors: Olivier Celso E. , Pinto Daiana G. , Teixeira Ana P. M. , Santana Jhéssica L. S. , Santos Raquel A. P. G. , Lima Regiane P. S. 
Published: December 2021

Background: The diagnosis of non-IgE mediated food allergies may be a complex puzzle when there is no start point to establish an elimination diet to allow a clear clinical field to initiate diagnostic Oral Food Challenges tests.
Objective: To evaluate the opportunity of the tube titration of precipitins to select food allergens to proceed with elimination diets to assist the diagnosis and management of adult patients with Food Allergy manifested as Intrinsic Atopic Dermatitis (IAD).
Methods: The tube titration of specific precipitins against anamnesis-chosen food allergens were performed in 64 IAD patients and their titers were associated with an Improvement Verbal Scale Rate (IVSR) of the patient’s perception of the benefits of the Precipitins-based Elimination Diet (PED) performed with these specific food allergens, as well correlated with their positive or negative perception of the impairment of symptoms after the reintroduction of the Symptom-Related Food Allergen (SRFA).
Results: In most cases, the PED contributed to a significant clinical improvement that allowed the patients to evaluate the individual effect of the reintroduction of each food allergen on their diets. There was a significant positive correlation coefficient between the titers of the food-specific titration of precipitins and the percentage of positive SRFA (Pearson r = 0.91; p-value = 0.0004).
Conclusion: The semiquantitative titration of specific precipitins against food allergens is a promising triage test to select food allergens to proceed with elimination diets to support the diagnosis and management of non-IgE mediated Food Allergy in patients with Intrinsic Atopic Dermatitis.
The Effect of Increasing Surface Area of Dialyzer Membrane on Adequacy of Hemodialysis
Authors: Saeed Faiza , Alam Ashar , Memon Shoukat , Imtiaz Salman 
Published: December 2021

Introduction: The patients with end stage renal disease requires 12 hours of hemodialysis per week divided in three equal sessions (4 hours/day for 3 days/week). Some studies show that adequacy of hemodialysis can be maintained by increasing the surface area of the dialyzer membrane and decreasing the frequency of treatment which can help the poor socioeconomic status patients in getting effective hemodialysis at a low cost.
Objectives: To observe whether by increasing the surface area of dialyzer the dose of dialysis can be reduced against the standard hemodialysis prescription.
Study design: Randomized Control Trial.
Study Duration: Six months from March 2017 to August 2017.
Settings: Department of Nephrology, The Indus Hospital Karachi.
Subjects: ESRD patients undergoing Hemodialysis for at least 6 months at The Indus Hospital Karachi.
Methods: In this prospective randomized control study, a total of 60 patients of end stage renal disease receiving hemodialysis for more than six months were included and divided into 2 groups randomly (Arm-A: twice weekly dialysis using a larger surface area dialyzer and Arm-:B thrice weekly dialysis using regular surface area dialyzer).
Results: A total of 59 (30 in Arm A and 29 in Arm B) patients were enrolled in the study out of which majority of the patients were male (59.3%). On average significantly higher URR and eKt/V were reported in Arm A whereas, higher mean standard (weekly) stdKt/V was reported in Arm-B.
Conclusion: Standard protocols should be followed to maintain the adequacy of Hemodialysis.
Attaining Sustainable Development Goal for Newborn Survival: Reinforcing Postnatal Interventions
Authors: Daga Subhashchandra 
Published: December 2021

Under the sustainable development goals (SDG), the target for neonatal mortality rate (NMR) was proposed to be less than 12 per 1000 live births by 2030 and may not meet the SDG 2030 NMR target. It may be prudent to focus on moderately low birth weight babies, 1500-2499 g, to reach the goal. This category of babies constitutes 37% of newborn deaths. They need supervised care for a short period that consists of the provision of warmth and breastfeeding with or without antibiotic therapy, and with or without oxygen administration. Despite knowing that these interventions can reduce neonatal deaths, deficiencies in how to implement these measures may be making all the difference to the expected outcome.
This paper suggests possible ways to enhance the effectiveness of some of the better-known interventions such as the provision of warmth, feeding, resuscitation, oxygen administration, delivery of continuous positive airway support, and antibiotic therapy.
Association between Osteoporosis and Metabolic Syndrome in Postmenopausal Women
Authors: Muraduzzaman S. M. , Begum S. , Siddika A. , Islam A. , Sultana S. , Mili U. S. , Saiedullah M. , Alam F. 
Published: December 2021

The risk of osteoporosis is higher in elderly and postmenopausal women. Several studies in different populations investigated the association between osteoporosis and metabolic syndrome (MS); however, the results are conflicting. In our population, no study has yet been conducted to evaluate this relationship in postmenopausal women. The aim of the study was to determine the relationship between osteoporosis and metabolic syndrome in postmenopausal women. In this study, a total of 131 postmenopausal women were included. Clinical history and anthropometric data were recorded and subjected to blood collection and scan for bone mineral density (BMD) and T-score at the lumbar spine and femoral neck and by dual-energy x-ray absorptiometry (DEXA). Osteoporosis and osteopenia were defined from T-score. The lipid profile was estimated by standard spectrophotometric methods. The mean±SD of age (years) of the postmenopausal women was 57.0±8.4. Bone mineral densities (g/cm2) were 0.78±0.17, 0.75±0.16, 0.72±0.16 and T-scores were -2.32±1.54, -1.52±1.29, -1.53±1.39 respectively in lumbar spine, right femoral neck and left femoral neck. Osteoporosis and osteopenia were found in 58 (44.3%) and 45 (34.4%) study subjects, respectively. Eighty-three (63.4%) of the study subjects have metabolic syndrome (MS). On multiple regression analysis, considering BMD at lumbar spine, right femoral neck or left femoral neck as dependent variable and age, body mass index (BMI), and MS as independent variables, β values for MS with BMD were -0.041 (p = 0.184), 0.002 (p = 0.938), 0.011 (p = 0.688) and with T-score were -0.330 (p = 0.241), -0.005 (p = 0.984), 0.151 (p = 0.599) at lumbar spine and right femoral neck and left femoral neck respectively. The coefficient of osteoporosis with MS in multiple logistic regression analysis was β = 1.311, (p = 0.003). In conclusion, osteoporosis is found to be positively associated with metabolic syndrome in postmenopausal women.
Working from Home: Impact on Wellbeing and Work-Life Balance
Authors: Gorjifard Roya , Crawford Joanne 
Published: December 2021

Working from home (WFH), teleworking, or telecommuting has become a new work norm since the Covid-19 pandemic. Many organisations are showing an interest in testing a hybrid work style when the pandemic is over; a mix of WFH with office-based work has the potential to improve work-life balance (WLB). Organisations across the globe quickly adopted WFH to maintain their business continuity during the pandemic. However, it co-concurred with particular occupational health and safety (OHS) concerns. Our research review shows that the frequency of WFH is significantly related to its impact on WLB. Women, specifically, are more likely to find it challenging to maintain balance between office work and domestic responsibilities. Additionally, WFH leads to personal costs for many, for example, maintaining a suitable workstation setup at home. The continuous demand for up-skilling/re-skilling due to fast improving technology and job satisfaction is another example of the risk to workers’ wellbeing.
This research paper reviews the most important risk determinants of WLB due to WFH. We discuss that workplaces should align their strategies in the longer term to support employees’ wellbeing risk management. Employers, employees – women particularly – should use this rapid change as an opportunity to learn and grow.
Exploring factors contributing to young workers’ vulnerability to work-related harm
Authors: Manglicmot Manfred , Cotton Olivia , Chen Sonia , Crawford Joanne 
Published: December 2021

New Zealand has experienced significant increases in youth employment rates in the last 20 years with 40 per cent of people employed part-time. This age group has been associated with the second-highest rate of injury claims. At the current time, there is limited information on why young workers in New Zealand are more vulnerable to work-related harm. This project aimed to explore this with a convenience sample of young workers using an online survey. Participants represented a diverse ethnic population but the sample was predominately female. In total, 32.7 per cent of respondents had received no occupational health and safety (OHS) training when starting work. Fifty-seven per cent of the sample thought that OHS was valued by their employer. Interestingly, 63 per cent of the sample said they would be confident about speaking up about an OHS issue with most being willing to speak to their manager. In relation to stress, the analysis identified that there was an association between feeling stressed and being unable to follow OHS protocols (p=0.05). While this was a small exploratory study, suggestions made to improve OHS include clear and open communication between workers and employers, improved access to OHS resources and continuous and in-depth training.
Legal status of cryptocurrency in Asian countries
Authors: Logoida V.M. 
Published: December 2021

The article is devoted to the study of the experience of legal regulation of the legal status of cryptocurrencies and transactions with them in Asian countries (except for the People's Republic of China and Asian countries - members of the Commonwealth of Independent States, as the author examined them in separate publications). In the article the author, based on the study of regulations, administrative and judicial practice of all major countries in this part of the world, emphasizes the divergent trends in cryptocurrency transactions regulation in the region, when some countries move from a liberal approach to the use of cryptocurrencies to their total ban and vice versa. It is noted that almost all countries in the region give a legal assessment of the payment function of cryptocurrencies, using regulatory or prohibitive approaches, depending on the chosen policy, which indirectly confirms their understanding of the legal nature of cryptocurrencies primarily as a means of payment. At the same time, these countries not only categorically distinguish cryptocurrencies from fiat money issued by central banks, but also mostly avoid the official definition of cryptocurrency as private (decentralized) cash, preferring to qualify them as an intangible asset, virtual asset, digital asset, financial value and even a good or service, which is currently a kind of compromise between political expediency and economic realities. The author also notes that the Asian region is characterized by very active attempts to resolve the legal status of cryptocurrencies at the legislative level, and not just administrative or judicial response to the actual legal relationship, although the progress of different countries in this matter is different.
As a result, the author concludes that in the Asian countries considered in the article, there is no same view on the legal nature of cryptocurrency, its qualification as an object of civil rights, and ways to regulate transactions with it (libertarian approach, positive-cryptocurrency approach but with detailed government regulation and control or a completely restrictive policy in relation to the cryptocurrency market).