bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature Sensitivity After Burn Injury: A Burn Model System National Database Hot Topic
Authors: Oh Jamie , Madison Christopher , Flott Grace , Brownson Elisha G , Sibbett Stephen , Seek Carolina , Carrougher Gretchen J , Ryan Colleen M , Kowalske Karen , Gibran Nicole S , Stewart Barclay T 
Published: July 2021

AbstractPeople living with burn injury often report temperature sensitivity. However, its epidemiology and associations with health-related quality of life (HRQOL) are unknown. We aimed to characterize temperature sensitivity and determine its impact on HRQOL to inform patient education after recovery from burn injury. We used the multicenter, longitudinal Burn Model System National Database to assess temperature sensitivity at 6, 12, and 24 months after burn injury. Chi-square and Kruskal–Wallis tests determined differences in patient and injury characteristics. Multivariable, multilevel generalized linear regression models determined the association of temperature sensitivity with Satisfaction with Life (SWL) scale scores and Veterans RAND 12 (VR-12) physical and mental health summary component (MCS) scores. The cohort comprised 637 participants. Two thirds (66%) experienced temperature sensitivity. They had larger burns (12% TBSA, interquartile range [IQR] 4–30 vs 5% TBSA, IQR 2–15; P &lt; .0001), required more grafting (5% TBSA, IQR 1–19 vs 2% TBSA, IQR 0–6; P &lt; .0001), and had higher intensity of pruritus at discharge (11% severe vs 5% severe; P = .002). After adjusting for confounding variables, temperature sensitivity was strongly associated with lower SWL (odds ratio [OR] −3.2, 95% confidence interval [CI] −5.2, −1.1) and MCS (OR −4.0, 95% CI −6.9, −1.2) at 6 months. Temperature sensitivity decreased over time (43% at discharge, 4% at 24 months) and was not associated with poorer HRQOL at 12 and 24 months. Temperature sensitivity is common after burn injury and associated with worse SWL and MCS during the first year after injury. However, temperature sensitivity seems to improve and be less intrusive over time.
The Patient’s Perspective: Burn Reconstructive Surgery During the COVID-19 Pandemic
Authors: Won Paul , Celie Karel-Bart , Perez Violeta , Gillenwater T Justin , Yenikomshian Haig A 
Published: July 2021

Abstract
During the coronavirus disease 2019 (COVID-19) pandemic, hospital systems delayed or halted elective surgeries and outpatient care, profoundly disrupting reconstructive burn treatment ranging from surgery to postoperative therapy. This study aims to characterize burn patients’ perspectives on reconstructive surgery during COVID-19. A 12-component questionnaire to burn patients awaiting reconstructive surgery at a single ABA-verified Burn Center was administered. Responses regarding willingness to undergo reconstruction, perceived medical and personal impacts of COVID-19, and perspectives on telehealth were gathered. Surveys were administered to patients/caregivers over the phone in English and Spanish. Inclusion criteria consisted of burn patients who had elective reconstructive surgeries delayed or canceled as a result of the pandemic. Fifty-one patients met our inclusion criteria. Of those, 23 patients responded to our survey (45%). Average patient age was 23, 43% were male, and a majority (52%) were pediatric. Twenty-two (96%) patients were willing to undergo reconstruction during the COVID-19 pandemic, despite a perceived increased risk. Forty-three percentage of patients disagreed or strongly disagreed that telehealth adequately enabled communication with their burn care provider. Seventy-eight percentage of patients agreed or strongly agreed that they felt more susceptible to COVID-19 as burn patients. Eighty-three percentage of patients agreed or strongly agreed that the COVID-19 pandemic had created stressors specifically related to their burn care. The majority of patients expressed a strong desire to return to surgical and therapeutic care delayed by COVID-19. Patients reported feeling especially vulnerable to the COVID-19 pandemic as burn patients and cited difficulty obtaining care and financial stressors as the main causes.
Coleridge and Newman: Four Aspects
Authors: Insausti Gabriel 
Published: July 2021

Abstract
The influence of Coleridge on Newman has often been cited, but it has also been disputed. Newman himself sometimes denied it or simply expressed his surprise at the ‘coincidences’. In this article I focus on different aspects of Newman’s thought where such influence is apparent: the idea of a ‘sacramental system’, the Church of England as a via media, the theory of development in dogma, and the self. Newman’s mixed feelings about Coleridge are also analysed and an explanation for these is provided.
Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients
Authors: Tonogai Emily J , Huang Shan , Botham Rachel C , Berry Matthew R , Joslyn Stephen K , Daniel Gregory B , Chen Zixin , Rao Jianghong , Zhang Xiang , Basuli Falguni , Rossmeisl John H , Riggins Gregory J , LeBlanc Amy K , Fan Timothy M , Hergenrother Paul J 
Published: July 2021

AbstractBackgroundHigh-grade meningioma is an aggressive type of brain cancer that is often recalcitrant to surgery and radiotherapy, leading to poor overall survival. Currently, there are no FDA-approved drugs for meningioma, highlighting the need for new therapeutic options, but development is challenging due to the lack of predictive preclinical models.MethodsTo leverage the known overexpression of procaspase-3 in meningioma, PAC-1, a blood-brain barrier penetrant procaspase-3 activator, was evaluated for its ability to induce apoptosis in meningioma cells. To enhance the effects of PAC-1, combinations with either hydroxyurea or temozolomide were explored in cell culture. Both combinations were further investigated in small groups of canine meningioma patients and assessed by MRI, and the novel apoptosis tracer, [18F]C-SNAT4, was evaluated in patients treated with PAC-1 + HU.ResultsIn meningioma cell lines in culture, PAC-1 + HU are synergistic while PAC-1 + TMZ show additive-to-synergistic effects. In canine meningioma patients, PAC-1 + HU led to stabilization of disease and no change in apoptosis within the tumor, whereas PAC-1 + TMZ reduced tumor burden in all three canine patients treated.ConclusionsOur results suggest PAC-1 + TMZ as a potentially efficacious combination for the treatment of human meningioma, and also demonstrate the utility of including pet dogs with meningioma as a means to assess anticancer strategies for this common brain tumor.
Institutions and macroeconomic performance: core versus periphery countries in the Eurozone
Authors: Christou Tryfonas , Philippopoulos Apostolis , Vassilatos Vanghelis 
Published: July 2021

Abstract
We incorporate institutions into a neoclassical growth model so as to account for macroeconomic differences, as in the data, in 12 Eurozone countries. Modelling institutions in a generic way, we assume that weak institutions are reflected in ill-enforced property rights. When we calibrate and solve the model for each country separately, our results are: (i) including weak institutions helps the model vis-à-vis the data more in the periphery than in the core of the Eurozone; (ii) institutional failures, and their adverse effects on incentives, are worse in the periphery countries and this contributes in explaining lower long-term growth and higher output volatility in these countries; (iii) the same shock affects different countries differently depending on their institutional structure and the mix of fiscal policies; and (iv) counterfactual scenarios imply that periphery countries with weak institutions could gain a lot had their institutional quality been like that in the core.
Safety of Tedizolid as Suppressive Antimicrobial Therapy for Patients With Complex Implant-Associated Bone and Joint Infection due to Multidrug-Resistant Gram-Positive Pathogens: Results From the TediSAT Cohort Study
Authors: Ferry Tristan , Conrad Anne , Senneville Eric , Roux Sandrine , Dupieux-Chabert Céline , Dinh Aurélien , Lustig Sébastien , Goutelle Sylvain , Briot Thomas , Pham Truong-Thanh , Valour Florent 
Published: July 2021

Abstract
A prospective cohort study was conducted to evaluate long-term safety of tedizolid as suppressive antimicrobial treatment in patients with implant-associated bone and joint infection caused by multidrug-resistant gram-positive pathogens. Seventeen patients received tedizolid with a median duration of treatment of 6 months. No patients developed a serious adverse event.
New developments in ankylosing spondylitis—status in 2021
Authors: Klavdianou Kalliopi , Tsiami Styliani , Baraliakos Xenofon 
Published: July 2021

Abstract
Axial SpA (axSpA) is a common rheumatic disease characterized by inflammation leading to bone formation and functional impairment. TNF-α and IL-17 represent established targets in axSpA. TNF-α and IL-17 inhibitors have demonstrated efficacy in clinical trials and are currently approved biologic DMARDs for all subsets of the disease. Several lines of evidence implicate a role of an IL-23–IL-17 axis in the disease pathogenesis. In this light, and given the success of IL-17 blockade in axSpA, a similar good response to IL-23 was anticipated. Nevertheless, two clinical trials of anti-IL-23 monoclonal antibodies in axSpA have clearly exhibited negative results. This failure has raised theories for a degree of IL-23 independent pathway. The Janus kinase (JAK) pathway is also a potential therapeutic target, since several cytokines, including those involved in the IL-23–IL-17 axis, signal through the JAK family of tyrosine kinases. Further studies and more extended evaluation of response to cytokine inhibition across different tissues will be required to improve our understanding of SpA pathogenesis and determine its optimal management.
A novel MTPA and flux weakening method of stator flux oriented control of PMSM
Authors: Wen Yuliang , Zheng Hanfeng , Yang Fang , Zeng Xiaofan 
Published: July 2021

Abstract
Permanent magnet synchronous motor (PMSM) has the advantages of high efficiency, high power density and high reliability. It has been widely used in electric vehicles, rail transit, industrial transmission and other fields. Compared with the traditional PMSM control strategy, the Indirect stator-quantities control (ISC) of low torque ripple induction motor has high dynamic response performance in the whole speed range, with high stability and strong security. However, due to the inherent characteristics of PMSM, there are still some difficulties in applying ISC strategy, such as solving the load angle corresponding to the current torque, realizing the maximum torque per ampere (MTPA) control and flux weakening control method in the stator field oriented control algorithm of PMSM. In this paper, theoretical analysis and discussion are carried out for the above difficulties, and an indirect stator vector control (ISC) method for PMSM is proposed. Finally, combined with the electric drive application platform of electric vehicle, the simulation and experimental results verify that the proposed ISC control strategy of PMSM also has good dynamic and steady-state performance in the whole speed range.
SARS-CoV-2 antibody prevalence in Sierra Leone, March 2021: a cross-sectional, nationally representative, age-stratified serosurvey
Authors: Barrie Mohamed Bailor , Lakoh Sulaiman , Kelly J. Daniel , Kanu Joseph Sam , Squire James , Koroma Zikan , Bah Silleh , Sankoh Osman , Brima Abdulai , Ansumana Rashid , Goldberg Sarah A. , Chitre Smit , Osuagwu Chidinma , Maeda Justin , Barekye Bernard , Numbere Tamuno-Wari , Abdulaziz Mohammed , Mounts Anthony , Blanton Curtis , Singh Tushar , Samai Mohamed , Vandi Mohamed A. , Richardson Eugene T. 
Published: July 2021

ABSTRACTBackgroundAs of 26 March 2021, the Africa CDC had reported 4,159,055 cases of COVID-19 and 111,357 deaths among the 55 African Union Member States; however, no country has published a nationally representative serosurvey as of May 2021. Such data are vital for understanding the pandemic’s progression on the continent, evaluating containment measures, and policy planning.MethodsWe conducted a cross-sectional, nationally representative, age-stratified serosurvey in Sierra Leone in March 2021 by randomly selecting 120 Enumeration Areas throughout the country and 10 randomly selected households in each of these. One to two persons per selected household were interviewed to collect information on socio-demographics, symptoms suggestive of COVID-19, exposure history to laboratory-confirmed COVID-19 cases, and history of COVID-19 illness. Capillary blood was collected by fingerstick, and blood samples were tested using the Hangzhou Biotest Biotech RightSign COVID-19 IgG/IgM Rapid Test Cassette. Total seroprevalence was was estimated after applying sampling weights.FindingsThe overall weighted seroprevalence was 2.6% (95% CI 1.9-3.4). This is 43 times higher than the reported number of cases. Rural seropositivity was 1.8% (95% CI 1.0-2.5), and urban seropositivity was 4.2% (95% CI 2.6-5.7).InterpretationAlthough overall seroprevalence was low compared to countries in Europe and the Americas (suggesting relatively successful containment in Sierra Leone), our findings indicate enormous underreporting of active cases. This has ramifications for the country’s third wave (which started in June 2021), where the average number of daily reported cases was 87 by the end of the month—this could potentially be on the order of 3,700 actual infections, calling for stronger containment measures in a country with only 0.2% of people fully vaccinated. It may also reflect significant underreporting of incidence and mortality across the continent.FundingThis study was supported by NIAID K08 AI139361, the Sierra Leone Ministry of Health and Sanitation, and the Africa CDC.
The health impacts of a 4-month long community-wide COVID-19 lockdown: Findings from a prospective longitudinal study in the state of Victoria, Australia
Authors: Griffiths Daniel , Sheehan Luke , Petrie Dennis , van Vreden Caryn , Whiteford Peter , Collie Alex 
Published: July 2021

AbstractObjectivesTo determine health impacts during, and following, an extended community lockdown and COVID-19 outbreak in the Australian state of Victoria, compared with the rest of Australia.MethodsA national cohort of 898 working-age Australians enrolled in a longitudinal cohort study, completing surveys before, during, and after a 112-day community lockdown in Victoria (8 July – 27 October 2020). Outcomes included psychological distress, mental and physical health, work, social interactions and finances. Regression models examined health changes during and following lockdown.ResultsThe Victorian lockdown led to increased psychological distress. Health impacts coincided with greater social isolation and work loss. Following the extended lockdown, mental health, work and social interactions recovered to an extent whereby no significant long-lasting effects were identified in Victoria compared to the rest of Australia.ConclusionThe Victorian community lockdown had adverse health consequences, which reversed upon release from lockdown. Governments should weigh all potential health impacts of lockdown. Services and programs to reduce the negative impacts of lockdown may include increases in mental health care, encouraging safe social interactions and supports to maintain employment relationships.
Sigma70Pred: A highly accurate method for predicting sigma70 promoter in prokaryotic genome
Authors: Patiyal Sumeet , Singh Nitindeep , Ali Mohd. Zartab , Pundir Dhawal Singh , Raghava Gajendra P.S. 
Published: July 2021

AbstractSigma70 factor plays a crucial role in prokaryotes and regulates the transcription of most of the housekeeping genes. One of the major challenges is to predict the sigma70 promoter or sigma70 factor binding site with high precision. In this study, we trained and evaluate our models on a dataset consists of 741 sigma70 promoters and 1400 non-promoters. We have generated a wide range of features around 8000 which includes Dinucleotide Auto-Correlation, Dinucleotide Cross-Correlation, Dinucleotide Auto Cross-Correlation, Moran Auto-Correlation, Normalized Moreau-Broto Auto-Correlation, Parallel Correlation Pseudo Tri-Nucleotide Composition, etc. Our SVM based model achieved maximum accuracy 97.38% with AUROC 0.99 on training dataset, using 200 selected features. In order to check the robustness of our model we have tested our model on the independent dataset made by using latest version of RegulonDB10.8, which included 1134 sigma70 and 638 non-sigma70 promoters, and able to achieve accuracy of 90.41% with AUROC of 0.95. We have developed a method, Sigma70Pred, which is available as webserver and standalone packages at https://webs.iiitd.edu.in/raghava/sigma70pred/. The services are freely accessible.
Clonal hematopoiesis of indeterminate potential is associated with worse kidney function and anemia in a cohort of patients with advanced chronic kidney disease
Authors: Vlasschaert Caitlyn , McNaughton Amy J. M. , Hopman Wilma , Kestenbaum Bryan , Robinson-Cohen Cassianne , Garland Jocelyn , Moran Sarah M. , Holden Rachel , Lanktree Matthew B. , Rauh Michael J. 
Published: July 2021

AbstractBackgroundClonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells. CHIP is common in aging populations and associated with cardiovascular morbidity and overall mortality, but its role in chronic kidney disease (CKD) has not been investigated.MethodsWe performed targeted sequencing to detect CHIP mutations in a cohort of 87 adults with eGFR < 60 ml/min/1.73m2. Kidney function, hematologic, and mineral bone disease parameters were assessed cross-sectionally at baseline, and a total of 2,091 creatinine measurements and 3,382 hemoglobin measurements were retrospectively collected over the following 12-year period.ResultsAt baseline, 20 of 87 (23%) cohort participants had CHIP detected. Those with CHIP had lower baseline eGFR (22.3 ± 11.2 vs. 28.2 ± 11.5 ml/min/1.73 m2, P = 0.04) in age- and sex-adjusted regression models. Individuals with CHIP had a 2.5–fold increased risk of incident 50% decline in eGFR or ESKD in a Cox proportional hazard model adjusted for age and sex (95% confidence interval, 1.3–4.7). The annualized rate of eGFR decline adjusted for age and sex was -2.3 ±1.1 ml/min/1.73m2 per year in those with CHIP versus -1.6 ±0.5 ml/min/1.73m2 per year in those without CHIP. Further, those with CHIP had lower hemoglobin at baseline (11.6 ± 0.3 vs. 12.8 ± 0.2 g/dL, P = 0.0003) and throughout the follow-up period despite a greater use of erythropoiesis-stimulating agents.ConclusionIn those with pre-existing CKD, CHIP was associated with lower eGFR at baseline, faster progression of CKD, and anemia.
Intrinsic Network Connectivity Reflects the Cyclic Trajectory of Migraine Attacks
Authors: Stankewitz Anne , Schulz Enrico 
Published: July 2021

AbstractBackgroundEpisodic migraine is considered to be cyclic in nature, triggered by the hypothalamus. To assess the natural trajectory of intrinsic networks over an entire migraine cycle, we designed a longitudinal intra-individual study using functional magnetic resonance imaging (fMRI).MethodsIntrinsic network connectivity was assessed for 12 migraineurs in 82 sessions including spontaneous, untriggered headache attacks and follow-up recordings towards the next attack.ResultsWe found cyclic changes in the visual, auditory, and somatosensory networks, in limbic networks (e.g. thalamo-insular, parahippocampal), and in the salience network (anterior insula and dorsal anterior cingulate cortex). Connectivity changes also extended to further cortical networks, such as the central executive network, the default mode network, as well as subcortical networks.Almost all of these network connectivity changes followed the trajectory of a linear increase over the pain-free interval that peaked immediately prior to the headache, and “dropped” to the baseline level during the headache. These network alterations are associated with a number of cortical functions that may explain the variety of ictal and pre-ictal physiological and psychological migraine symptoms.ConclusionOur results suggest that migraine disease is associated with widespread cyclic alterations of intrinsic networks that develop before the headache is initiated, i.e. during the interictal and premonitory phase. The increasing magnitude of connectivity within these networks towards the next attack may reflect an increasing effort to maintain network integrity.
Oculomotor plant and neural dynamics suggest gaze control requires integration on distributed timescales
Authors: Miri Andrew , Bhasin Brandon J. , Aksay Emre R. F. , Tank David W. , Goldman Mark S. 
Published: July 2021

ABSTRACTA fundamental principle of biological motor control is that the neural commands driving movement must conform to the response properties of the motor plants they control. In the oculomotor system, characterizations of oculomotor plant dynamics traditionally supported models in which the plant responds to neural drive to extraocular muscles on exclusively short, subsecond timescales. These models predict that the stabilization of gaze during fixations between saccades requires neural drive that approximates eye position on longer timescales and is generated through the temporal integration of brief eye velocity-encoding signals that cause saccades. However, recent measurements of oculomotor plant behaviour have revealed responses on longer timescales. Furthermore, measurements of firing patterns in the oculomotor integrator have revealed a more complex encoding of eye movement dynamics. Yet, the link between these observations has remained unclear. Here we use measurements from the larval zebrafish to link dynamics in the oculomotor plant to dynamics in the neural integrator. The oculomotor plant in both anaesthetized and awake larval zebrafish was characterized by a broad distribution of response timescales, including those much longer than one second. Analysis of the firing patterns of oculomotor integrator neurons, which exhibited a broadly distributed range of decay time constants, demonstrates the sufficiency of this activity for stabilizing gaze given an oculomotor plant with distributed response timescales. This work suggests that leaky integration on multiple, distributed timescales by the oculomotor integrator reflects an inverse model for generating oculomotor commands, and that multi-timescale dynamics may be a general feature of motor circuitry.KEY POINTSRecent observations of oculomotor plant response properties and neural activity across the oculomotor system have called into question classical formulations of both the oculomotor plant and the oculomotor integrator.Here we use measurements from new and published experiments in the larval zebrafish together with modelling to reconcile recent oculomotor plant observations with oculomotor integrator function.We developed computational techniques to characterize oculomotor plant responses over several seconds in awake animals, demonstrating that long timescale responses seen in anesthetized animals extend to the awake state.Analysis of firing patterns of oculomotor integrator neurons demonstrates the sufficiency of this activity for stabilizing gaze given an oculomotor plant with multiple, distributed response timescales.Our results support a formulation of gaze stabilization by the oculomotor system in which commands for stabilizing gaze are generated through integration on multiple, distributed timescales.