bluuebunny/crossref_metadata_2025_split huggingface dataset:
Сучасні погляди на проблему датування Таємної Вечері. Частина 1 Календарне вирішення датування Таємної вечері
Authors: Санніков Сергій 
Published: July 2021

У статті аналізуються різні підходи до вирішення проблеми пов'язаної з характером і датуванням так званої Таємної вечері, яку провів Ісус Христос зі своїми учнями перед своєю смертю. Описи, представлені в синоптичних Євангеліях явно вказують, що ця подія відбулася в четвер увечері і представляло собою пасхальний седер. Наратив Євангелії Івана ясно показує, що єврейська пасхальна вечерю мала відбутися в п'ятницю. Узгодженням цих двох наративів богослови займаються вже тривалий час.
Стаття докладно демонструє різні рішення цієї проблеми, які стали популярні в останні десятиліття. Автор показує, що провідні біблеїсти сучасності все частіше повертаються до традиційної точки зору, що Остання вечеря Христа була дійсно пасхальної трапезою, а не дружній (несакральной) зустріччю хабурів, яку Ісус бажав провести у вузькому колі найближчих учнів.
Перший розділ статті присвячений одному з найбільш модний напрямків - календарному вирішення проблеми датування Останньої вечері Ісуса. У статті висвітлюються особливості та етапи становлення єврейського календаря. Також аналізується гіпотеза, детально розроблена Анні Жобер, яка ґрунтується на наявності в юдаїзмі Другого храму різних календарних варіацій і супротивних груп, які по-різному розуміли особливості святкування релігійних свят.
Анні Жобер розвинула теорію двох календарів на основі псевдоепіграфа Книги ювілеїв і кумранских рукописів із залученням відомостей з патристичній літератури. На її думку Христос провів пасхальну юдейську трапезу з споживанням агнця з 12 апостолами не в четвер, а у вівторок, тому що Він використав не офіційний храмовий місячно-сонечний календар, а сонячний календар єсеїв, описаний в книзі Ювілеїв. Деякі підтвердження цієї гіпотези можна зустріти в роботах Єпіфанія Кіпрського та Вікторина Петавійского. У статті наводяться основні аргументи критиків цієї гіпотези. Зокрема, з точки зору Жобер треба відкинути наративи синоптичних Євангелій, вважаючи їх пізніми дописами, стає незрозуміло, як храмове священство могло допустити заклання агнців єсеїв на кілька днів раніше за встановлений термін, особливо зважаючи на їх дуже напружені стосунки. Також немає ніяких документальних підтверджень аналогічних випадків в історії юдаїзму. Таким чином, календарна теорія має як ряд серйозних підтверджень, так і чимало слабких аргументів.
У наступному числі цього видання буде подано так зване рабиністичне вирішення датування Останньої вечері і його докладний огляд. У поза наступному числі цього видання буде розглядатися астрономічний та інші концепти цієї проблеми.
DRUG REPURPOSING: IN SILICO BASED STUDY ON REPURPOSING PHYTOCHEMICALS ON INFLUENZA
Authors: Sonawadekar Chinmay , Kamble Rashmi , Sawant Saloni , Joshi Sriya 
Published: July 2021

By and by, the world is in a battle with the novel Influenza and with no prompt medicines accessible the scourge brought about by the disease is expanding step by step. A ton of researchers are continuing for the potential medication up-and-comer that could help the medical care framework in this battle. In recent years, studies of phytoconstituents have gradually increased worldwide because the natural sources and variety of such plants allow them to complement modern pharmacological approaches. As computer technology has developed, in silico approaches such as virtual screening and network analysis have been widely utilized in efforts to elucidate the pharmacological basis of the functions of phytoconstituents. We present a docking?based screening using a quantum mechanical scoring of a library built from approved drugs and compounds that Curcumin, Gallic Acid, Phenethyl Isothiocyanate, Piperine, with Proteins Neuraminidase, Hemagglutinin, M1 and M2 Matrix proteins having PDB IDs 3BEQ, 4WE8, 5V6G, 6BKL respectively, could display antiviral activity against Influenza. Clearly, these compounds should be further evaluated in experimental assays and clinical trials to confirm their actual activity against the disease. We hope that these findings may contribute to the rational drug design against Influenza.
Keywords: PDB IDs 3BEQ, 4WE8, 5V6G, 6BKL
WORKSHOP PENGENALAN METODE PENELITIAN KUANTITATIF MELALUI SOFTWARE SPSS DALAM MENGHADAPI ERA NEW NORMAL DI SMK SWASTA AL WASHLIYAH 3 MEDAN, KOTA MEDAN, PROVINSI SUMATERA UTARA
Authors: Juliandri Panjaitan Dedy , Aprilia Rima 
Published: July 2021

Covid-19 merupakan ancaman bagi berbagai sektor kehidupan. Selain kesehatan, Covid-19 turut mengancam kehidupan sosial, ekonomi, pendidikan, dan politik di berbagai Negara. Pada sektor pendidikan, model pembelajaran harus dilakukan jarak jauh secara daring. Hal ini mengakibatkan terjadinya persaingan dunia kerja yang sangat ketat, untuk itu lembaga pendidikan khususnya Sekolah Menegah Kejuruan (SMK) harus mampu menyiapkan peserta didiknya untuk dapat bersaing dalam dunia kerja. Dalam rangka memenuhi kebutuhan Guru-Guru dalam pengelolaan data statistik dan menunjang era new normal serta era revolusi industri 4.0 yang telah dilaksanakan pemerintah maka kami berusaha untuk merealisasikan kebutuhan tersebut dengan melaksanakan kegiatan PKM yang didanai oleh Dana Internal Universitas Muslim Nusantara Al Washliyah. Target luaran yang dihasilkan dari kegiatan ini secara umum adalah guru-guru dan siswa di SMK Swasta Al Washliyah 3 Medan mahir menggunakan media SPSS (Statistical Product for Service Solutions) sebagai media mengolah data. Secara khusus, target luaran kegiatan adalah sebagai berikut: (1). Guru dan siswa mampu menggunakan data sesuai dengan desain penelitian yang telah ditentukan dengan tepat, benar dan jujur; (2). mampu mengolah data sesuai dengan desain penelitian yang telah ditentukan dengan tepat, benar dan jujur; (3). dapat mengolah data penelitian dengan waktu yang cepat dan benar.
PENTINGNYA PENGGUNAAN PROGRAM APLIKASI INSTRUMENTASI DATA UNTUK MENGGALI ARAH PEMINATAN PESERTA DIDIK SMP DI KABUPATEN PAMEKASAN
Authors: Supriadi Agus 
Published: July 2021

With so many tasks that must be completed cultivated fields by teachers Guidance and Counseling which consists of four fields, eleven types of services, and six support units. The teacher then Guidance and Counseling feel overwhelmed and unable to complete the task becomes all areas mandate, particularly in data collection and usage instrumentation applications. Unfinished inability to complete all the administrative tasks of the Guidance and Counseling teacher, now coupled with new task field known as Direction Specialisation, which according to teachers Guidance and Counseling " jobs that seem more time-consuming, and difficult to resolve in a short time ". So that guidance and counseling teacher performance was not optimal. In this research method is discussed about the development, stages, testing, and analysis products. To obtain the necessary data , the researchers chose 20 people teachers Guidance and Counseling are incorporated in MGBK (Musyawarah Guru Bimbingan dan Konseling ; Deliberation Teacher Guidance and counseling) Pamekasan as test subjects with treatment instrumentation applications utilizing the data direction of specialization. With this treatment were then given a questionnaire to determine the performance associated with speed and ease before and after using the instrumentation application of data toward specialization
From the results of this development was obtained performance without using a program based on the pace of work = 38 : 80 = 0.475 or 47.5 % of the expected criteria. From the aspects of ease in working = 38 : 80 = 0.475 or 47.5 % of the expected criteria. While using the application program instrumentation toward specialization junior learners views on aspects of the system working speed = 66 : 80 = 0.825 or 82.5 % of that expected. Ease in working = 65 : 80 = 0.8125 or 81.25 % of the expected. For the lowest working system is the convenience aspect, which reached 81.25 % of the expected. From the calculation we can conclude the difference between a working system without and with using the program. So that the application program instrumentation specialization direction data can be harnessed and used by teachers Guidance and Counseling in Pamekasan to improve performance in the implementation of the service. Suggestions can be submitted to the user program the data instrumentation applications, especially towards specialization learners in making its recommendation sheet, to be able to properly and optimally utilize it possible to increase the performance of services to students of teaching.
MOTIVASI BELAJAR SISWA MIS I'ANATUSHIBYAN 02 PARUNG
Authors: Nurlailah Nurlailah , Oktapiani Rika , Ika  
Published: July 2021

Besides that, school is also a product where humans are educated and nurtured to become smart, productive, and qualifield human beings. The main purpose of education is to help students develop every potential that exsists in them so that they can become human beings who are balanced between their personal and social lives. The quality of student education outcomes can be determined by many factors, one of the most important is student motivation. Student motivation to learn greatly determines the success achieved by these student. Student who have high learning motivation will be able to achieve high learning achievement as well, but conversely, stuydent who have low motivation tend to get low learning achievement as well and will experience higher learning disabilities. To help increase a student’s motivation to learn, it is necessary to know the level of student motivation to learn. The phenomenon in the field shows that the level of student learning motivation is very important to know so that it can help these student to improve it, this is known after the researcher conducted interviews with supervisors at the school, according to the supervisor some students in the school had low motivation. To actively participate in teaching and learning activities in the classroom. Student motivation in this study is related to motivation, driving, change, and goals of motivation it self. The school that was taken as the research location was MI I’anatusshibyan 02 Parung. The students referred to in this study were all students of MI I’anatusshibyan 02 Parung.
Strategi Komunikasi Pemasaran Kae Thai Tea Dalam Meningkatkan Brand Awareness
Authors: Noti Fetnisari Babang , Widodo Herru Prasetya , Setiamandani Emei Dwinanarhati 
Published: July 2021

The current business competition is so tight that there are many similar competitors. This is where a brand awareness strategy is needed so that the business being run can still compete. This study aims to determine the strategies used by Kae Thai Tea in increasing this brand awareness. In this study, a qualitative research method was used through observation, documentation and semi-structured interviews with informants who were determined through positive sampling. From the research carried out, it can be concluded that in carrying out a marketing communication strategy to increase brand awareness, this goal can be achieved by implementing a well-organized strategy in accordance with the wishes of the businessman. As for several supporting factors, namely the elements of marketing communication and brand elements by having a concept that is quite affordable. The presence of several inhibiting factors will not make the marketed brand worse but will become stronger in the face of competition.
Keywords: communication; marketing communication; brand awareness
Pengembangan Bahan Ajar Berorientasi Environmental Sustainability Education Berbasis Literasi Sains Dan Realitas Lokal Sumatera Selatan
Authors: Anggraini Nike , Nazip Khoiron , Andriani Dian Sri 
Published: July 2021

Penelitian ini merupakan penelitian pengembangan bahan ajar berorientasi environmental sustainability education berbasis literasi lingkungan dan realitas Sumatera Selatan.. Subjek dalam penelitian ini adalah penelitian yakni mahasiswa Pendidikan Biologi FKIP Unsri yang sedang mengampu Mata Kuliah Manusia dan Ilmu Lingkungan. Penelitian ini menggunakan desain penelitian Research & Development (R&D) dari Borg dan gall dengan emapt tahapan yakni studi pendahuluan, perencanaan, pengembangan, validasi dan revisi. Uji coba terbatas dilakukan pada sebagian mahasiswa kelas palembang yang berjumlah 15 orang dan uji coba skala luas dilakukan pada keseluruhan mahasiswa berjumlah 75 dari keseluruhan mahasiswa di kelas palembang dan indralaya. Bahan ajar yang digunakan dikembangkan menurut NAEE dengan 6 karateristik kunci bahan ajar berorietasi Environmental Sustainability Education yang meliputi : fairness & accuracy, depth, emphasis on skill building, action orientation, instructional soundness dan usability. Teknik Pengumpulan data dilakukan melalui observasi, dokumentasi, angket dan tes. Uji keterbacaan menggunakan tes Cloze dan sebelumnya dilakukan tes validasi oleh ahli materi, dan ahli teknologi. Berdasarkan hasil validasi oleh ahli materi didapat bahwa 82, 4% , 78% oleh validasi ahli teknologi, yang artinya bahan ajar yang dikembangkan dalam kategori baik. Sedangkan brdasarkan uji keterbacaan, bahan ajar lingkungan memiliki keterbacaan yang tinggi.
MiR-665 Regulates Vascular Smooth Muscle Cell Senescence by Interacting With LncRNA GAS5/SDC1
Authors: Chen Tianbin , Liang Qingyang , Xu Jialin , Zhang Yanan , Zhang Yi , Mo Liping , Zhang Li 
Published: July 2021

Background: Vascular aging is considered a special risk factor for cardiovascular diseases, and vascular smooth muscle cells (VSMCs) play a major role in aging-related vascular remodeling and in the pathological process of atherosclerosis. Recent research has reported that long non-coding RNA/microRNA (lncRNA/miRNA) is a critical regulator of cellular senescence. However, the role and mechanism of lncRNA GAS5/miR-665 axis in VSMC senescence remain incompletely understood.Methods: Cellular senescence was evaluated using senescence-associated β-gal activity, the NAD+/NADH ratio, and by immunofluorescence staining of γH2AX immunofluorescence. Differentially expressed miRNAs (DEMs) were identified by miRNA microarray assays and subsequently validated by quantitative real-time PCR (qRT-PCR). A dual luciferase reporter assay was conducted to confirm the binding of lncRNA GAS5 and miR-665 as well as miR-665 and syndecan 1 (SDC1). Serum levels of miR-665, lncRNA GAS5, and SDC1 in 93 subjects were detected by qRT-PCR. The participants were subdivided into control, aging, and early vascular aging (EVA) groups, and their brachial-ankle pulse wave velocity (baPWV) was measured.Results: A total of 20 overlapping DEMs were identified in young and old VSMCs via microarray analysis. MiR-665 showed a significant alteration and, therefore, was selected for further analysis. Upregulation of miR-665 was found in aging VSMCs, and downregulation of miR-665 caused an inhibition of VSMCs senescence. Subsequently, the dual luciferase reporter assay determined the binding site of miR-665 with the 3′-UTR of lncRNA GAS5 and SDC1. Increased expression of lncRNA GAS5 expression inhibited the miR-665 level and VSMC senescence. However, as shown in rescue experiment results, either miR-665 overexpression or SDC1 knockdown significantly reversed the effects of lncRNA GAS5 on VSMC senescence. Finally, compared with that of the control group, miR-665 was highly expressed in serum samples in the aging and EVA groups, especially in the EVA groups. On the contrary, serum levels of lncRNA GAS5 and SDC1 were lower in these two groups. Collectively, in the aging and EVA groups, miR-665 expression was negatively correlated with lncRNA GAS5 and SDC1 expression.Conclusion: miR-665 inhibition functions as a vital modulator of VSMC senescence by negatively regulating SDC1, which is achieved by lncRNA GAS5 that sponges miR-665. Our findings may provide a new treatment strategy for aging-related cardiovascular diseases.
Feasibility and Preliminary Effects of the BESMILE-HF Program on Chronic Heart Failure Patients: A Pilot Randomized Controlled Trial
Authors: Chen Xiankun , Jiang Wei , Olson Thomas P. , Lundborg Cecilia Stålsby , Wen Zehuai , Lu Weihui , Marrone Gaetano 
Published: July 2021

Aims: The Baduanjin Eight-Silken-Movements wIth Self-Efficacy building for Heart Failure (BESMILE-HF) program is a contextually adapted cardiac rehabilitation program. It uses a traditional Chinese exercise, Baduanjin, to solve the unmet demand of exercise-based cardiac rehabilitation programs due to their scarcity and unaffordability in China. This pilot study assesses BESMILE-HF's feasibility and preliminary effects.Methods: Eighteen patients with chronic heart failure were included: 8 in a BESMILE-HF group (age: 67 ± 5 years, EF: 40.4 ± 13.6%) and 10 in a control group (age: 70 ± 13 years, EF: 42.9 ± 12.5%). Both received the usual medications, with the intervention group receiving additionally the BESMILE-HF program for 6 weeks. Feasibility was explored by participants' involvement in the intended intervention. Clinical outcome assessments were conducted at baseline and post-intervention, while adverse events were captured throughout the study period.Results: The BESMILE-HF program was well-received by patients, and adherence to the intervention was good. The intervention group completed all required home exercises and total home-practice time was correlated with baseline self-efficacy (r = 0.831, p = 0.011). Moreover, after 6 weeks, self-efficacy increased in the BESMILE-HF group (p = 0.028) and the change was higher than in the control [mean difference (MD): 3.2; 95% confidence interval (CI) 0.6–5.9, p = 0.004]. For the exercise capacity, the control group demonstrated a significant decline in peak oxygen consumption (p =0.018) whereas, the BESMILE-HF group maintained their exercise capacity (p = 0.063). Although the between-group difference was not statistically significance, there was clear clinical improvement in the BESMILE-HF group (1.5 mL/kg/min, 95% CI, −0.3 to 3.2 vs. minimal clinically important difference of 1 mL/kg/min). Throughout the study period, no adverse events related to the intervention were captured.Conclusions: BESMILE-HF is feasible for patients with chronic heart failure in Chinese settings. A larger sample size and a longer follow-up period is needed to confirm its benefit on clinical outcomes.Clinical Trial Registration:ClinicalTrials.gov: NCT03180320.
Improving Academic Self-Concept and STEM Identity Through a Research Immersion: Pathways to STEM Summer Program
Authors: Betz Amy R. , King Brenee , Grauer Bette , Montelone Beth , Wiley Zelia , Thurston Linda 
Published: July 2021

Undergraduate research opportunities have been demonstrated to promote recruitment, retention, and inclusion of students from underrepresented groups in STEM disciplines. The opportunity to engage in hands-on, discovery-based activities as part of a community helps students develop a strong self-identity in STEM and strengthens their self-efficacy in what can otherwise be daunting fields. Kansas State University has developed an array of undergraduate research opportunities, both in the academic year and summer, and has established a management infrastructure around these programs. The Graduate School, which hosts its own Summer Undergraduate Research Opportunity Program aimed at URM and first-generation college students, coordinates the leadership of the other grant-funded programs, and conducts a series of enrichment and networking activities for students from all the programs. These include professional development as well as primarily social sessions. The Kansas LSAMP, led by Kansas State University, created a summer program aimed at under-represented minority community college students enrolled in STEM fields to recruit them into research opportunities at K-State. There has been strong interest in the program, which incorporated university experience elements in addition to an introduction to STEM research and the four-year university. In the 5 years since the program’s inception, cohorts of nine to fourteen students came to K-State each year for eight-week experiences and took part in both cohort-based sessions and individual mentored research experiences. The two-fold focus of this program, Research Immersion: Pathways to STEM, has resulted in the majority of the students presenting a poster at a national conference and transferring to a STEM major at a four-year institution. Survey results showed that the program was successful at improving STEM identity and academic self-concepts. Qualitative feedback suggested that the two parts of the program worked together to increase interest and self confidence in STEM majors but also ensured that students connect with other students and felt comfortable in the transition to a 4-year institution.
Suicidal Ideations and Behavior in Patients With Young and Late Onset Dementia
Authors: Ortner Marion , Riedl Lina , Jox Ralf J. , Hartmann Julia , Roßmeier Carola , Dorn Bianca , Kehl Victoria , Egert-Schwender Silvia , Fischer Julia , Diehl-Schmid Janine 
Published: July 2021

Background and Objectives: Data on suicidal ideation, behavior and the risk factors in patients with dementia is scarce. To evaluate the prevalence of death wishes, suicidal ideation, and suicidal behavior of young (YOD) and late onset dementia (LOD) and to identify risk factors for suicidal ideation and behavior.Methods: We interviewed 157 family caregivers of patients with advanced dementia using questions from the Columbia-Suicide Severity Rating Scale to gather information about suicidal ideation and behavior before the onset of symptoms of dementia, after the onset of dementia and within 30 days prior to the interview. At the time of the interview, we also assessed disease severity, cognitive function, and other psychological, behavioral and physical symptoms of the patients as well as the caregivers' psychological well-being.Results: Forty four (28%) of the patients expressed suicidal ideation or behavior at some time after the onset of symptoms, and 14 (9%) of these within the month prior to the assessment. Two patients had attempted suicide after the onset of dementia. There were no statistically significant differences between patients with and without suicidal ideations or behavior with regards to demographics or age at onset of dementia. In patients with advanced dementia, Alzheimer's disease (rather than frontotemporal lobar degeneration), better cognitive function, more severe psychological, behavioral, and physical symptoms, and a reduced quality of life were associated with the expression of suicidal ideation.Conclusions: According to caregivers' reports, majority of patients with dementia did not express suicidal ideation or show suicidal behavior. Patients who expressed suicidal ideation during early stages of dementia often stopped expressing them in advanced stages. It remains unclear if this was due to reduced communication abilities, a reduction of disease awareness, and/ or an adjustment to their situation.