bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetohydrodynamic peristaltic flow of Bingham fluid in a channel: An application to blood flow
Authors: C Rajashekhar , G Manjunatha , Mebarek-Oudina F. , Vaidya Hanumesh , K V Prasad , K Vajravelu , A Wakif 
Published: June 2021

The paper examined a theoretical investigation of the stimulus of mass and heat transfer on the channel's peristaltic utilization of the MHD Bingham liquid. The research study is motivated to explore blood circulation in the little vessels by taking the slip, variable thermal conductivity, and thickness of the wall features into account. The leading constitutive equations are established based on low Reynolds number and approximations for long wavelengths. The solution for the resulting nonlinear energy and momentum equations is obtained using a semi-analytic method, while the exact solution for the concentration field is obtained. Using the MATLAB software, the influences of different constraints on the interest of physiological quantities are represented graphically. One of the considerable outcomes of the current model exposes that the existence of variable fluid properties boosts the rate as well as temperature level areas. The rheological and flow properties of various biological fluids can be derived from this model as a particular case. Moreover, the formation of stuck bolus diminishes for larger values of the magnetic and velocity slip constraints.
Cardiovascular risk profiles and stress echocardiography results in patients with hypertensive response to exercise
Authors: Karev E. A. , Malev E. G. , Suvorov A. Yu. , Verbilo S. L. , Prokudina M. N. 
Published: June 2021

Aim. To compare markers of high cardiovascular risk and stress echocardiography results depending on the type of blood pressure (BP) response to exercise in patients without obstructive coronary artery disease.Material and methods. Our single-center cross-sectional study included 96 patients without hemodynamically significant coronary artery stenosis according to coronary angiography or multislice computed tomography angiography. All patients underwent physical examination, cardiovascular risk stratification, electrocardiography, extracranial cerebrovascular ultrasound, echocardiography, treadmill exercise stress echocardiography.Results. According to the test results, the patients were divided into groups with a hypertensive response (n=41) and a normal response to exercise (n=55). Patients with hypertensive response to exercise had significantly higher values of left ventricular mass index (100,0 (90,0; 107,0) g/m2 vs 76,0 (68,0; 91,0) g/m2, p<0,0000001) and left atrial volume index (36,7 (32,0; 46,0) ml/m2 vs 29,7 (26,3; 32,0) ml/m2, p=0,000003). There was also a higher level of cardiovascular SCORE risk (5,0 (2,0; 6,0) vs 2,0 (1,0; 3,0), p=0,004); patients more often had associated clinical conditions (36,6% vs 12,7%, χ2=7,57, p=0,006) and left ventricular diastolic dysfunction (39,02% vs 78,18%, χ2=15,21, p=0,0001). Pathological BP increase during stress echocardiography was associated with worse exercise tolerance (7,4 (5,6; 10,0) METs vs 10,2 (8,4; 11,95) METs, p=0,000041) and more frequent transient regional contractility impairment (46,34% vs 1,8%, p<0,00001), mainly of the lateral and inferior left ventricular walls.Conclusion. Despite the absence of coronary artery stenosis, patients with hypertensive response to exercise are significantly more likely to have markers of high cardiovascular risk and require more careful monitoring of risk factors. Also, the hypertensive response to exercise is associated with more frequent regional contractility impairment even without coronary artery stenosis.
Association of psychosocial stress with the social environment, lifestyle and risk factors for cardiovascular diseases in middle-aged male Muscovites
Authors: Kotova M. B. , Rozanov V. B. , Aleksandrov A. A. , Drapkina O. M. 
Published: June 2021

Aim. To study the relationship of psychosocial stress with the social environment, lifestyle and risk factors for cardiovascular diseases (CVDs) in middle-aged men.Material and methods. A total of 301 men aged 41-44 years were examined. The study included a clinical examination and a survey using a standard questionnaire. The categorization of CVD risk factors (RF) was carried out in accordance with generally accepted criteria. The psychosocial stress was assessed using the Reeder scale. Depending on the psychosocial stress level, all surveyed men were divided into 3 groups by tertiles: group 1 (3,28-4,0 points) — mild stress, group 2 (2,71-3,14) — moderate stress, group 3 (1,28-2,57) — severe stress.Results. More than half (53,5%) of males had manifestations of psychosocial stress, while 9% had a mild stress. With an increase in stress severity, the prevalence of hypertension increased and was significantly higher in men with a severe stress compared with their peers with mild stress (45,7% vs 31,7%; p=0,045). A significant linear trend was revealed between the levels of PSS and indicators of sedentary behavior. The strongest linear relationship was found between the psychosocial stress level and vital exhaustion (VE). The level of VE, stress at work, satisfaction with government performance and the level of family happiness are independent determinants of psychosocial stress level, and explain 33,1% of its variability. The proportion of the variance of psychosocial stress, uniquely explained by VE, is 20,8%, the absence of stress at work — 8,0%, satisfaction with government performance — 3,5% and the level of family happiness — 2,0%.Conclusion. A high level of psychosocial stress in middle-aged men is associated with hypertension, sedentary lifestyle and lower values of most indicators of the social environment, lifestyle and quality of life. This must be taken into account along with other behavioral and psychosocial risk factors for noncommunicable diseases when developing population-based programs.
Association of high-sensitivity C-reactive protein with fatal and non-fatal cardiovascular events in working-age people: data from the ESSE-RF study
Authors: Evstifeeva S. E. , Shalnova S. A. , Kutsenko V. A. , Yarovaya E. B. , Balanova Yu A. , Imaeva A. E. , Kapustina A. V. , Muromtseva G. A. , Maksimov S. A. , Karamnova N. S. , Samokhina Yu. Yu. , Drapkina O. M. , Kulakova N. V. , Trubacheva I. A. , Efanov A. Yu. , Shabunova A. A. , Belova O. A. , Rotar O. P. 
Published: June 2021

Aim. To study the relationship of different levels of high-sensitivity C-reactive protein (hs-CRP) with cardiovascular events and assess its contribution to the development of outcomes in Russian regions.Material and methods. The work used the data from the multicenter study ESSE-RF — a representative sample of male and female population aged 25-64 years. All participants signed informed consent. The study included 10421 people (women, 6399 (61,4%)). The cohort was followed up from 2012 to 2019 (median follow-up period, 5,5 years). A hard endpoint (cardiovascular mortality and nonfatal myocardial infarction (MI)) was determined in 187 people, while a soft endpoint (nonfatal MI, stroke, revascularization, heart failure progression and cardiovascular mortality) — in 319 people.Results. The results showed that hs-CRP is significantly associated with the main risk factors (with the exception of low-density lipoproteins). At the same time, it was found that optimal hs-CRP level for predicting the risk of cardiovascular events (CVE) in Russian population is significantly lower than 3 mg/L, but higher than 1 mg/L (1,54/1,89 mg/dL for men and women, respectively). Adding hs-CRP to sex and age significantly improved risk prediction (AUC, 79,7; 95% CI, 77,8-81,7). At the same time, adding a wide list of confounders to hs-CRP, sex and age does not improve the model’s predictive value (AUC, 79,7; 78,2-82,1).Conclusion. This study for the first time showed a significant independent contribution of hs-CRP to CVEs development in the Russian population, and the addition of hs-CRP to sex and age significantly increased the predictive value of model.
Engagement e Burnout na docência no ensino superior na área da saúde: revisão integrativa
Authors: Meyer Lucas Filadelfo , Gehr Tamires Elisa , Gonçalves Letícia dos Santos , Mendes Juliana Ollé , Makuch Débora Maria Vargas , Zagonel Ivete Palmira Sanson 
Published: June 2021

INTRODUÇÃO: A docência no ensino superior na área da saúde se enquadra como uma categoria profissional intensamente exposta a estressores psicossociais. Por conseguinte, os fatores atrelados ao engagement e à Síndrome de Burnout (SB) são constructos que permeiam o exercício docente. OBJETIVO: evidenciar pela revisão de literatura científica como se dá o engagement e Síndrome de Burnout na docência no ensino superior na área da saúde. MATERIAIS E MÉTODOS: A busca pelos estudos foi realizada nas bases de dados Biblioteca Virtual em Saúde (BVS), Web of Science e Science Direct; uma vez aplicados os critérios de inclusão e exclusão, resultaram 6 artigos. RESULTADOS: Conforme o ano de publicação, 33,3% dos artigos foram desenvolvidos em 2017, 33% em 2013 seguidos por 17% em 2012 e em 2011 respectivamente; em se tratando dos resultados dos trabalhos selecionados, quanto à SB tem-se com maior frequência as variáveis idade, sexo, estado civil e atividades de extensão do docente; para que haja a prevenção da SB é necessário propiciar um ambiente de trabalho saudável, em que deve-se observar a amplificação de políticas, procedimentos e sistemas concebidos, de modo a fazer com que os colaboradores se tornem capazes de atingir os objetivos organizacionais e, concomitantemente, alcancem satisfação em sua ocupação profissional. CONCLUSÃO: Desta forma, conclui-se que, a partir de ambientes adequados de trabalho, estímulos ao desenvolvimento docente, relações laborais saudáveis, estrutura propícia à prática docente, e favorecimento da saúde física, mental e psíquica destes profissionais, as instituições perceberão resultados positivos no processo de ensino e aprendizagem.
İnme Sonrası Erken Dönem Epileptik Nöbet Geçiren Bir Olgunun Kolcaba’nın Konfor Kuramına Göre Değerlendirilmesi
Authors: ÇALIŞKAN Türkan , KARADAKOVAN Ayfer 
Published: June 2021

Bireyin nörolojik fonksiyonlarının kalıcı ya da geçici kaybıyla sonuçlanan kronik bir hastalık olan inme sonrasında, kayıp yaşanan enstrümental günlük yaşam aktivitelerinin yeniden kazanılmasında hemşirelik bakımının konfor sağlayıcı rolü önemlidir.
Bu çalışmada, Konfor kuramı çerçevesinde; inme tanısı almış ve epileptik nöbet geçiren 82 yaşındaki erkek bir olgunun, aktivite kısıtlılığı nedeni ile yaşadığı konfor sorunlarına ilişkin hemşirelik yönetimi ele alınmış ve kuramın kullanımına yönelik bir örnek oluşturulması amaçlanmıştır.
Results of revascularizing operations performed in the acute period of subarachnoid hemorrhage
Authors: Lukyanchikov V. A. , Shetova I. M. , Shtadler V. D. , Kudryashova N. E. , Guseynova G. K. , Kiseleva А. A. , Krylov V. V. 
Published: June 2021

The study objective is an assessment of long-term results of cerebral revascularization performed in the acute period of subarachnoid hemorrhage due to rupture of cerebral aneurysms.Materials and methods. This cross-sectional study includes 74 patients, operated in N.V. Sklifosovsky Research Institute for Emergency Medicine in the acute period of aneurysmal subarachnoid hemorrhage. Patients were divided into two groups. The first group contained patients with EC—IC bypass performed in the acute period of aneurysmal subarachnoid hemorrhage. The Control group contained patients without bypass. In the long-term period, 11 patients were examined. Computed tomography of cerebral vessels, duplex ultrasound examination of the aortic arch, brachiocephalic arteries and intracranial vessels, transcranial Doppler ultrasonography with a breathing function test, single-photon emission computed tomography of the brain followed by stress test with acetazolamide, Modified Renkin Scale, Mini-Mental State Examination, Montreal Cognitive Assessment, Index Bartel, The Hospital Anxiety and Depression Scale, Holms-Rahe were performed. For descriptive results, a mathematical model was used.Results. The best treatment outcomes in severe patients with subarachnoid hemorrhage and cerebral ischemia were observed when performing simultaneous clipping of the aneurysm and EC-IC bypass (57.1 % versus 41.0 %) there was no statistically significant difference in outcomes. EC-IC bypass functioned in 37.5 % of cases. The rate and acceleration of the fall in volumetric blood flow and the passage of blood from the aortic bulb to the cerebral arterioles affect the perfusion values in the region of the brain concerned. Evaluation of long-term results of simultaneous interventions revealed persistent disturbances in the regulation of cerebral blood flow at the microcirculatory level. Patients with EC-IC bypass had a higher level of cognitive function and stress potential.Conclusion. The results of this study showed us the necessity for a comprehensive exploration of cerebral blood flow.
Cranioplasty of post-trepanation skull defects using additive 3D printing technologies
Authors: Brattsev I. S. , Smetanina O. V. , Yashin K. S. , Gorbatov R. O. , Ermolaev A. Yu. , Morev А. V. , Yarikov A. V. , Medyanik I. A. , Karyakin N. N. 
Published: June 2021

Introduction. Every year, there is an increase in the number of operations performed using personalized cranioplasts, which are made with additive 3D printing technologies. They allow surgical intervention, taking into account the characteristics of the shape of the patient's skull. This is especially important when closing large and complex defects extending from the cranial vault to the bones of the facial skeleton. One of the innovative applications of additive technologies in cranioplasty is the creation of implants, preformed based on individual 3D-printed models. However, no preliminary estimates of the results of treatment of patients using the traditional methods of cranial implants and individualized modeling methods were found in the available literary sources.The study objective is to compare the results of treatment using cranioplasts, preformed based on individual 3D-printed skull models and using traditional intraoperative modeling.Materials and methods. A study of 50 patients with post-craniotomy defects of the skull. All patients have undergone cranioplasty. Depending on the technique of individualization of the cranial implants, patients were divided into 2 groups: 1st - using individual 3D-printed models (n = 32), 2nd - traditional intraoperative modeling (n = 18).Results. Statistically, the groups differed significantly in terms of the duration of the intraoperative stage of cranioplasty, postoperative and total hospital stay, indicators of symmetry and financial costs. No differences were found in the duration of the preoperative hospital stay, the number of implant fixation points, the volume of intraoperative blood loss and the quality of life according to the SF-36. The first group (6.25 %) in comparison with the second (16.7 %) had a smaller number of postoperative complications.Conclusion. Modern 3D printing technologies recreate bone models based on patients' individual characteristics, thereby providing time for careful planning of the operation, even at the outpatient stage. The results of the study showed that the usage of cranioplasts preformed with 3D-printed models provides precise closure of post-craniotomy defects, better restoration of the skull contours, and a significant reduction in the duration of the cranioplasty stage. The use of the technology does not lead to a significant increase in the cost of treatment using traditional intraoperative modeling.
Microsurgical treatment of distal aneurysms of the middle cerebral artery
Authors: Lukyanchikov V. A. , Senko I. V. , Rijkova E. S. , Krylov V. V. , Dashyan V. G. 
Published: June 2021

The study objective is to investigate the features of distal aneurysms of the middle cerebral artery and to evaluate the results of their surgical treatment.Materials and methods. From 01/01/2000 to 12/31/2019 at the N.V. Sklifosovsky Research Institute of Emergency Medicine, 37 patients with distal SMA aneurysms were operated (21 women, 16 men, the average age of 48 y. o). SMA aneurysms were classified by their localization according to the classification of H. Gibo. The aneurysms of the M2 segment of the MCA were encountered more often (56.8 %). 28 aneurysms had a saccular structure, 9 (24.3 %) had a fusiform. The size of the saccular aneurysms ranged from 1.4 to 34.0 mm. More than 65 % of patients had aneurysms of 7 mm or less.Results. The surgical access was selected depending on the location of the MCA aneurysm. The pterional transsylvian access is used more often, less often - with aneurysms of the M4-segment, convexital trepanation. The reconstructive clipping of the distal SMA aneurysm was performed in 22 (59.4 %) cases, trapping and/or excision in 15 (40.5 %) cases. After the deconstructive intervention, revascularization was performed on 6 (16 %) patients.Conclusion. Distal aneurysms of the middle cerebral artery are a rare pathology that requires an individual approach -contact Doppler ultrasound or intraoperative angiography, intraoperative neuromonitoring, as well as, if necessary, the use of revascularization methods. To optimize surgical access, it is preferable to use neuronavigation.
Facial nerve preservation in stereotactic radiosurgery of tumors of the cerebellopontine cistern
Authors: Ilyalov S. R. , Kvashnin K. M. , Medvedeva K. E. , Baulin A. A. , Lepilina O. G. , Parshunina А. M. , Sygay N. A. 
Published: June 2021

Introduction. Surgery has traditionally remained the main treatment for tumors of the cerebellopontine cistern but is associated with high risks of dysfunction of the cranial nerves. Radiosurgery is usually performed both as an adjuvant treatment and as an independent option.The study objective is to assess the safety of routine use of radiosurgery to preserve facial nerve function in the treatment of tumors of different origins located in the cerebellopontine cistern.Materials and methods. Since March 2018 to March 2020 there were 145 patients with tumors of cerebellopontine cistern (CPC) at the Center for High-Precision Radiology. Vestibilar schwannomas were detected in 116 (80 %) patients, in 37 cases - relapses or remains after surgery. The 22 patients had meningiomas, 6 after open surgery (WHO I). Trigeminal schwannomas - in 3 patients, facial schwannomas - in 2, jugular schwannomas - in 1 and metastasis of prostate cancer - in 1. 31 patients had facial paresis of different degrees after previous surgery. Among non-operated patients, facial paresis before radiosurgery was observed in only 1 patient. Radiosurgery was performed using the Leksell Gamma Knife Perfexion, the mean marginal dose was 12.2 Gy (11-15 Gy), the mean tumor volume was 3.98 cm3 (0.06-17.47 cm3).Results. Follow-up was performed in 85 patients. The mean follow-up was 359.3 days (91-776), the median follow-up was 367 days. Reduction of the tumor volume was detected in 27 patients, stabilization of the process in 15. The average decrease was 23.9 % (95 % CI 16.8-31.0 %). Transient postirradiation increase was observed in 30 patients only in the group of schwannomas and mean tumor volume increase was 53.7 % (95 % CI 38.5-68.9 %). In patients with previous surgery there were not cases of decline or regression facial paresis. Among patients who had not been operated on before radiosurgery, only in 1 case was the development of facial paresis (House-Brackman III) 5 months after irradiation, which amounted to 1.8 %. It should be especially noted that facial nerve function remained unchanged (House-Brackman I) in both patients with facial schwannomas. Also, not a single case of hemifacial spasm was identified.Conclusion. Radiosurgery of CPC tumors with a marginal dose from 12 to 15 Gy has a high degree of safety in relation to the facial nerve. This makes it possible to justify radiosurgery as alternative to traditional neurosurgical interventions.
Dynamics of clinical and immunological parameters in the integrated management of endo-­periodontal lesions, including laser therapy
Authors: Blashkova S L , Krikun E V , Mustafin I G , Valeeva I Kh , Blashkova Ju V 
Published: June 2021

Aim. To determine the dynamics of clinical changes and indicators of local immunity in integrating the diode laser into the treatment of the endo-periodontal lesion.
Methods. We performed a prospective study of 110 patients of both sexes aged 2555 years with endo-periodontal lesions. The patients were randomized into two groups the main group (n=54), whose received root canal treatment and periodontal pockets with a diode laser in addition to standard therapy, which included endodontic and periodontal treatment, and control group (n=56), whose patients received only standard treatment. The GreenVermillion oral hygiene index and Russells periodontal index, as well as the levels of immunoglobulin (Ig) A, tumor necrosis factor-alpha (TNF-alpha) and cytokine interleukin-10 (IL-10) in the mixed saliva of patients, were determined during the study. Quantitative data were described using median, lower and upper quartiles. These data were visualized using boxplots. The MannWhitney U test was used to compare differences between an independent set of quantitative data. Differences were considered significant at a confidence level of p 0.05.
Results. The median oral hygiene index decreased from 2.9 to 1.0 (p 0.001) in the main group and from 2.9 to 1.6 (p 0.001) in the control group. The median Russell's periodontal index decreased from 3.38 to 1.3 (p 0.001) in the main group and from 3.95 to 2.0 (p 0.001) in the control group. The median immunoglobulin A content decreased from 5.25 to 3.13 mg/L (p 0.001) in the main group and from 5.23 to 4.21 mg/L (p 0.001) in the control group. The tumor necrosis factor-alpha level decreased from 16.65 pg/ml in the main group and 18.28 pg/ml in the control group to 3.96 and 8.44 pg/ml (p 0.001), respectively. The median cytokine interleukin-10 levels increased from 0.83 to 2.94 pg/ml (p 0.001) in the main group and from 1.29 to 2.13 pg/ml (p 0.001) in the control group.
Conclusion. The use of a diode laser in the treatment of endo-periodontal lesions has a positive effect on the dynamics of clinical and immunological parameters, as evidenced by a statistically significant decrease in clinical indices, as well as the normalization of the immunoglobulin A and cytokine levels in mixed saliva.