bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide association study on Northern Chinese identifies KLF2, DOT1L and STAB2 associated with systemic lupus erythematosus
Authors: Song Qin , Lei Yao , Shao Li , Li Weiyang , Kong Qingsheng , Lin Zhiming , Qin Xiao , Wei Wei , Hou Fei , Li Jian , Guo Xianghua , Mao Yujing , Cao Yujie , Liu Zhongyi , Zheng Lichuan , Liang Rui , Jiang Yuping , Liu Yan , Zhang Lili , Yang Jing , Lau Yu Lung , Zhang Yan , Ban Bo , Wang Yong-Fei , Yang Wanling 
Published: January 2021

Abstract

Objectives
To identify novel genetic loci associated with systemic lupus erythematosus (SLE) and to evaluate potential genetic differences between ethnic Chinese and European populations in SLE susceptibility.

Methods
A new genome-wide association study (GWAS) was conducted from Jining, North China, on 1506 individuals (512 SLE cases and 994 matched healthy controls). The association results were meta-analysed with existing data on Chinese populations from Hong Kong, Guangzhou and Central China, as well as GWAS results from four cohorts of European ancestry. A total of 26 774 individuals (9310 SLE cases and 17 464 controls) were included in this study.

Results
Meta-analysis on four Chinese cohorts identifies KLF2 as a novel locus associated with SLE [rs2362475; odds ratio (OR) = 0.85, P=2.00E-09]. KLF2 is likely an Asian-specific locus as no evidence of association was detected in the four European cohorts (OR = 0.98, P =0.58), with evidence of heterogeneity (P=0.0019) between the two ancestral groups. Meta-analyses of results from both Chinese and Europeans identify STAB2 (rs10082873; OR= 0.89, P=4.08E-08) and DOT1L (rs4807205; OR= 1.12, P=8.17E-09) as trans-ancestral association loci, surpassing the genome-wide significance.

Conclusions
We identified three loci associated with SLE, with KLF2 a likely Chinese-specific locus, highlighting the importance of studying diverse populations in SLE genetics. We hypothesize that DOT1L and KLF2 are plausible SLE treatment targets, with inhibitors of DOT1L and inducers of KLF2 already available clinically.
An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKI resistant cells by modulating miR-335 expression
Authors: Pal Debjani , Tepes Polona Safaric , Lindsted Trine , Ibarra Ingrid , Lujambio Amaja , Sabinina Vilma Jimenez , Senturk Serif , Miller Madison , Korimerla Navya , Huang Jiahao , Glassman Larry , Lee Paul , Zeltsman David , Hyman Kevin , Esposito Michael , Hannon Gregory J. , Sordella Raffaella 
Published: January 2021

ABSTRACTLung cancer remains the leading cause of cancer-related mortality worldwide, despite current advancements in research and therapeutics. Many patients diagnosed with lung cancer will develop resistance to chemotherapeutic agents. In the context of non-small cell lung cancers (NSCLC) harboring EGFR oncogenic mutations, augmented levels of AXL and GAS6 have been found to drive Erlotinib resistance in certain tumors with mesenchymal-like features. By studying the ontogeny of AXL-positive cells, we have identified a novel non-genetic mechanism of drug resistance based on cell-state transition. We demonstrate that AXL-positive cells are already present as a sub-population of cancer cells in Erlotinib-naïve tumors and tumor-derived cell lines, and that the expression of AXL is regulated through a stochastic mechanism centered on the epigenetic regulation of miR-335. The existence of a cell-intrinsic program through which AXL-positive/Erlotinib-resistant cells emerge infers the need of treating tumors harboring EGFR-oncogenic mutations upfront with combinatorial treatments targeting both AXL-negative and AXL-positive cancer cells.
Fertility care quality and experiential relationship marketing: a case study of mainland Chinese fertility tourists to Malaysia
Authors: Wu Hung-Che , Chen Xiaolian , Chang Ya-Yuan 
Published: January 2021

PurposeThis study examines the relationship between the dimensions of fertility care quality and the dimensions of experiential relationship marketing in fertility tourism.Design/methodology/approachThe data used in this study were based on a sample of 532 Mainland Chinese fertility tourists who received fertility care services in eight private fertility clinics in four Malaysian states, indicating that the proposed model fitted the data.FindingsFindings show that the dimensions of fertility care quality (professional skills, patient orientation and physical comfort) and experiential value positively influence experiential satisfaction. Additionally, experiential trust is positively influenced by both experiential satisfaction and experiential value. Also, experiential commitment is positively influenced by experiential satisfaction, experiential trust and experiential value.Practical implicationsFertility tourism service providers could focus on refining the dimensions of fertility care quality to improve experiential relationship marketing.Originality/valueThis paper provides the data that result in a better understanding of the relationship between the dimensions of fertility care quality and the dimensions of experiential relationship marketing in fertility tourism.
The effect of nWOM firestorms on South African retail banking
Authors: Lappeman James , Clark Robyn , Evans Jordan , Sierra-Rubia Lara 
Published: January 2021

PurposeThis study analysed the effect of online negative word-of-mouth (nWOM) firestorms in the retail banking sector. By understanding negative sentiment and sentiment recovery across an entire retail banking sector, the research exposed a unique view of banking in South Africa.Design/methodology/approachThe study made use of both a sentiment and topic analysis of over 1.7 million social media posts in South Africa. The methodology made use of both NLP and human validation techniques to measure changes in social media sentiment during online firestorms. This measurement included each of South Africa's major retail banks over a twelve month period.FindingsFrom the analysis, key trigger characteristics for these firestorms (product failures, service failures, social failures and communication failures) were categorised. In addition, the average duration of a firestorm was calculated and factors that impact sentiment recovery were explored.Originality/valueThe study was located in South Africa and, unlike firm level studies, researched nWOM for the whole retail banking sector. A theoretical footprint depicting the typical anatomy of a firestorm was derived in order to aid stakeholders to be more vigilant and better equipped to provide correct intervention in such times of crisis.
Fluffy PR and ‘comms girls’: banter, social interactions and the office culture in public relations in England
Authors: Topić Martina 
Published: January 2021

Purpose
The purpose of this paper was to explore social interactions, banter and the office culture in the public relations (PR) industry in England with the use of the difference approach and Bourdieu’s habitus theory. The paper explores whether PR organisations act as masculine habitus.

Design/methodology/approach
Qualitative interviews were conducted with 26 women practitioners, and thematic analysis was used to analyse data. Women were asked questions on social interactions, banter and the office culture, as well as questions on exclusion, from business decisions and having to work harder to succeed.

Findings
Findings show that two main themes dominate in responses from interviewees, “de-patriarchalisation” of PR with no personal appearance requirements and no business exclusions because of gender, and “gendered organisations” where interviewees reported dismissive stereotypes of women who work in PR, networking as a job requirement and differences between male-dominated and female-dominated offices, which includes differences between social interactions and banter among men and women.

Practical implications
Results indicate that women feel there are differences in social interactions and banter between men and women. Interviewees also report masculine domination as and harmful stereotypes of public PR professionals, most of whom are women. Organisations who have PR departments, as well as those who hire PR agencies to do the work externally, should design policies on the office culture to ensure equality and respectful work environment for everyone.

Social implications
In line with the difference approach, women report differences in social interactions and banter between them and men, thus signalling that social differences influence the office culture and work interactions, which tend to be gendered. Findings also indicate that organisations are functioning as a masculine world where women struggle to fit in and obtain recognition. Consciousness-raising is needed in the industry because many women do not recognise oppression in the form of social interactions, and its effect on the position of women or the fact that the most feminized industry is being trivialised by the men on top.

Originality/value
To the best of the author’s knowledge, this is the first paper analysing interactions in PR offices using the difference approach and Bourdieu’s habitus theory.
Older adults and “scams”: evidence from the Mass Observation Archive
Authors: Bailey Jan , Taylor Louise , Kingston Paul , Watts Geoffrey 
Published: January 2021

PurposeThe issue of financial abuse is highlighted in the Care Act (2014). One category of financial abuse is consumer fraud or “scams.” Evidence suggests that scams are becoming increasingly ubiquitous, yet how scams impact older adults remains under-researched. The purpose of this paper is to report data from 80 older adults’ written responses to a Mass Observation Archive Directive, commissioned in autumn 2015, which focused on scams.Design/methodology/approachA qualitative approach was used with data captured via written responses to a set of questions. There was no limit on the length of written accounts, and respondents remained anonymous. Data were analysed thematically, resulting in four key themes.FindingsThe data indicated scams impact individuals in terms of health and well-being, irrespective of whether they have experienced financial loss, and trigger implementation of strategies intended to avoid being defrauded. There was also evidence of scam-related stigma with individuals who are defrauded being subject to derision and censure.Social implicationsIndividuals who have been victimised by fraudsters may need access to practical and emotional support. This requires the design of appropriate interventions and the stigma associated with being scammed to be addressed.Originality/valueThis paper adopts an original approach to collecting rich, candid data about an under-researched topic. The authors highlight that anti-scam interventions should equip individuals to identify and avoid scams without inciting fear or anxiety; proposing this may be facilitated by drawing on health and safety risk assessment protocol when designing anti-scam interventions.
New organizational changes with blockchain: a focus on the supply chain
Authors: Varriale Vincenzo , Cammarano Antonello , Michelino Francesca , Caputo Mauro 
Published: January 2021

PurposeThe paper aims to present a systematic literature review (SLR) showing the benefits, challenges and future research of blockchain technology (BT) for the supply chain (SC), also suggesting how the features of BT can change the organizational aspects of the SC.Design/methodology/approachAn SLR has been conducted to detect papers that contained the word “Blockchain” in their titles, keywords or abstracts. Consequently, a second filter to analyze BT papers for the SC was applied.FindingsThis paper shows through 31 variables classified into positive, negative and future directions of technology for the SC. For instance, BT will reduce time consuming of operations management and payments using smart contracts. In addition, integrating BT with other technologies will allow product tracking and sustainable production management.Research limitations/implicationsThe selection of papers is limited to Scopus database and specifically to the Management Journal.Practical implicationsBT creates collaborative peer-to-peer and business-to-business markets. The technology automates several tasks such as order management, payment for goods, waste reduction and process control. Therefore, its use within the SCs will improve the productivity and profits of the participants.Originality/valueThis paper is focused on BT for the SC area with 60 articles analyzed. In addition, 13 variables on benefits, eight variables on challenges and 12 points on future research directions were analyzed. This work will help researchers and entrepreneurs to deepen about the changes that BT offers in SC.
People‐centered care for psoriasis and urticaria: Are we overlooking Internet addiction while only considering patients and physician settings?
Authors: Schielein Maximilian Christian , Tizek Linda , Baeumer Daniel , Hillmann Elena , Romer Katrin , Wagner Nicola , Zink Alexander 
Published: January 2021

AbstractPsoriasis and chronic urticaria (CU) are chronic skin diseases with a high impact on individuals’ life and mental health. Some studies indicate a high prevalence of Internet addiction and many affected individuals seem not to utilize healthcare, but rather search for health‐related information online. The aims of the study were to assess Internet addiction as a potential comorbidity in both diseases as well as identify differences in healthcare utilization between individuals with psoriasis and CU. This cross‐sectional study is based on self‐reported data from individuals with psoriasis and CU living throughout Germany using the framework of an online survey from 12/2018 to 01/2019. Advertisements on Google and Facebook were used to address Internet users who searched online for information on psoriasis or CU. The study questionnaire comprised questions on demographics, current contact with physicians, and disease history as well as validated screening tools for well‐being and Internet addiction. Overall, 1686 participants (74.0% female, 38.5% psoriasis) with a mean age of 36.9 ± 12.9 years were analyzed. Participants with CU were more likely female (89.2% vs 49.8%, P < 0.001) and not in medical care compared to participants with psoriasis (60.3% vs 45.9%, P < 0.001). Sixteen percent of the participants overall were screened positive for Internet addiction. Furthermore, not utilizing medical care showed a significant association with being screened positive for Internet addiction in participants with CU (adjusted odds ratio [aOR] = 1.49, 95% confidence interval [CI] 1.10–2.02), but not in those with psoriasis. The study revealed a high proportion of affected individuals not being in medical care and a high prevalence of Internet addiction, with individuals with CU not utilizing medical resources having a higher chance of being screened positive for Internet addiction. This underlines the approach of people‐centered care and highlights its importance for further research.
Trust in government increased during the Covid‐19 pandemic in Australia and New Zealand
Authors: Goldfinch Shaun , Taplin Ross , Gauld Robin 
Published: January 2021

AbstractUsing an online panel, we surveyed a representative sample of 500 each in Australia and New Zealand during July 2020, in the middle of the Covid‐19 pandemic. We find trust in government has increased dramatically, with around 80% of respondents agreeing government was generally trustworthy. Around three quarters agreed management of the pandemic had increased their trust in government. Over 85% of respondents have confidence that public health scientists work in the public interest. Testing four hypotheses, we find that income and education predict trust in government and confidence in public health scientists, as does voting for the political party in government. Trust in government and confidence in public health scientists strongly predict Covid‐19 phone application use, largely through convincing people the App is beneficial. Trust in government then is both an outcome and antecedent of government effectiveness. Building trust is important for governments implementing difficult policy responses during a crisis.
Rethinking capital structure decision and corporate social responsibility in response to COVID‐19
Authors: Huang He , Ye Ye 
Published: January 2021

AbstractCOVID‐19 has severely constricted global economic activities. This paper examines the joint effect of capital structure and corporate social responsibility (CSR) activities on firm risk during the COVID‐19 pandemic. We find that firms having excessive debt beyond the optimal level experienced high firm risk during the pandemic and the effect is more prevalent among firms with poor CSR performance. In contrast, firms with a debt level below the optimum are self‐protected regardless of their CSR practices. Our study provides businesses with insights on post‐pandemic directions of capital structure and CSR policies to build up sustainability and resilience in a volatile market.
Scandalous decisions: explaining shifts in UK medicinal cannabis policy
Authors: Monaghan Mark , Wincup Emma , Hamilton Ian 
Published: January 2021

AbstractBackground and aimsOpening up access to scheduled drugs such as cannabis in the United Kingdom rarely happens, yet on 1 November 2018 the United Kingdom changed the law to allow cannabis‐derived products to be prescribed for medicinal purposes, albeit in tightly controlled circumstances. This followed substantial media interest in the cases of two children with epilepsy. This article focuses upon the role of scandal in bringing about legislative change.MethodsWe used political science and social policy theories (punctuated equilibrium theory and scandal theory) to guide a qualitative content analysis of media articles published in 2018 in UK national newspapers. We focused in particular on the 6‐month period prior to the policy change.ResultsThe concentrated attention by the media given to the suffering of children with epilepsy appears to have prompted the rapid change in policy by the UK government. A variety of strategies were used to develop a highly emotive response to garner support for reform. Media stories emphasized the injustice of two extremely sick children being unable to access the medicine they apparently needed to enable them to have a ‘normal’ childhood. Three groups of ‘claim‐makers’ were identified as important in influencing public opinion: families, high‐profile individuals and campaigning groups.ConclusionsThe case of medicinal cannabis in the United Kingdom suggests that policy reform can occur when a scandal is successfully manufactured. We must be cautious, however, about over‐emphasizing the role of scandal as a driver of policy change in this context: only a limited set of circumstances will permit a prescription for cannabis‐based medicine to be issued in the United Kingdom.
Effectiveness of incentivised adherence and abstinence monitoring in buprenorphine maintenance: a pragmatic, randomised controlled trial
Authors: Elarabi Hesham Farouk , Shawky Mansour , Mustafa Nael , Radwan Doaa , Elarasheed Abuelgasim , Yousif Ali Ahmed , Osman Mona , Kashmar Ahmed , Al Kathiri Helal , Gawad Tarek , Kodera Ayman , Al Jneibi Mohammed , Adem Abdu , Lee Amanda J. , Marsden John 
Published: January 2021

ABSTRACTBackground and AimBuprenorphine (BUP) maintenance treatment for opioid use disorder (OUD) begins with supervised daily dosing. We estimated the clinical effectiveness of a novel incentivised medication adherence and abstinence monitoring protocol in BUP maintenance to enable contingent access to increasing take‐home medication supplies.DesignTwo‐arm, single‐centre, pragmatic, randomised controlled trial of outpatient BUP maintenance, with during‐treatment follow‐ups at 4 weeks, 8 weeks, 12 weeks and 16 weeks.SettingInpatient and outpatient addictions treatment centre in the United Arab Emirates.ParticipantsAdults with OUD, voluntarily seeking treatment.InterventionsThe experimental condition was 16 weeks BUP maintenance with incentivised adherence and abstinence monitoring (I‐AAM) giving contingent access to 7‐day, then 14‐day, then 21‐day and 28‐day medication supply. The control, treatment‐as‐usual (TAU) was 16 weeks BUP maintenance, with contingent access to 7‐day then 14‐day supply.MeasurementsThe primary outcome was number of negative urine drug screens (UDS) for opioids, with non‐attendance or otherwise missed UDS, imputed as positive for opioids. The secondary outcome was retention in treatment (continuous enrolment to the 16‐week endpoint).FindingsOf 182 patients screened, 171 were enrolled and 141 were randomly assigned to I‐AAM (70 [49.6%]) and to TAU (71 [50.4%]. Follow‐up rates at 4 weeks, 8 weeks, 12 weeks and 16 weeks were 91.4%, 85.7%, 71.0%, 60.0% respectively in I‐AAM and 84.5%, 83.1%, 69.0%, 56.3% in TAU. By intention‐to‐treat, the absolute difference in percentage negative UDS for opioids was 76.7% (SD = 25.0%) in I‐AAM versus 63.5% (SD = 34.7%) in TAU (mean difference = 13.3%; 95% CI = 3.2%–23.3%; Cohen's d = 0.44; 95% CI = 0.10–0.87). In I‐AAM, 40 participants (57.1%) were retained versus 33 (46.4%) in TAU (odds ratio = 1.54; 95% CI = 0.79–2.98).ConclusionsBuprenorphine maintenance with incentivised therapeutic drug monitoring to enable contingent access to increasing take‐home medication supplies increased abstinence from opioids compared with buprenorphine maintenance treatment‐as‐usual, but it did not appear to increase treatment retention.
Behavioral counseling and abstinence‐contingent take‐home buprenorphine in general practitioners’ offices in Malaysia: a randomized, open‐label clinical trial
Authors: Schottenfeld Richard S. , Chawarski Marek C. , Mazlan Mahmud 
Published: January 2021

AbstractBackground and aimTo address the widespread severe problems with opioid use disorder, buprenorphine–naloxone treatment provided by primary care physicians has greatly expanded treatment access; however, treatment is often provided with minimal or no behavioral interventions. Whether or which behavioral interventions are feasible to implement in various settings and improve treatment outcomes has not been established. This study aimed to evaluate two behavioral interventions to improve buprenorphine–naloxone treatment.DesignA 2 × 2 factorial, repeated‐measures, open‐label, randomized clinical trial.SettingsGeneral medical practice offices in Muar, Malaysia.ParticipantsOpioid‐dependent individuals (n = 234).InterventionsParticipants were randomly assigned to one of four treatment conditions and received study interventions for 24 weeks: (1) physician management with or without behavioral counseling and (2) physician management with or without abstinence‐contingent buprenorphine–naloxone (ACB) take‐home doses.MeasurementsThe primary outcomes were proportions of opioid‐negative urine tests and HIV risk behaviors [assessed by audio computer‐assisted AIDS risk inventory (ACASI‐ARI)].FindingsThe rates of opioid‐negative urine tests over 24 weeks of treatment were significantly higher with [68.2%, 95% confidence interval (CI) = 65–71] than without behavioral counseling (59.2%, 95% CI = 56–62, P < 0.001) and with (71.0%, 95% CI = 68–74) than without ACB (56.4%, 95% CI = 53–59, P < 0.001); interaction effects between and among behavioral interventions and time were not statistically significant. Scores on ACASI‐ARI decreased significantly from baseline across all treatment groups (P < 0.001) and did not differ significantly with or without behavioral counseling (P = 0.099) or with or without ACB (P = 0.339).ConclusionsProviding opioid‐dependent patients in Muar, Malaysia with buprenorphine–naloxone and physician management plus behavioral counseling or abstinence‐contingent buprenorphine–naloxone (ACB) resulted in greater reductions of opioid use compared with providing buprenorphine–naloxone and physician management without behavioral counseling or ACB.