bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geochemistry of deep Tunguska Basin sills, Siberian Traps: correlations and potential implications for the end-Permian environmental crisis
Authors: Callegaro S. , Svensen H. H. , Neumann E. R. , Polozov A. G. , Jerram D. A. , Deegan F. M. , Planke S. , Shiganova O. V. , Ivanova N. A. , Melnikov N. V. 
Published: June 2021

AbstractA vast portion of the plumbing system of the Siberian Traps Large Igneous Province (STLIP) is emplaced in the Tunguska Basin, where borehole data reveal ubiquitous and abundant sills with great lateral extension. These intrusions intersect Cambrian–Ordovician evaporite, carbonate and siliciclastic series, and locally coal-bearing Permian host rocks, with a high potential for thermogenic gas generation. Here we present new geochemical data from 71 magmatic and 4 sedimentary rock samples from the Tunguska Basin center and periphery, recovered from 15 deep sills intercepted by boreholes. The studied samples are all low-Ti basalt and basaltic andesites, confirming absence of high-Ti and alkaline STLIP magmatism in the Tunguska Basin. The sills derive from picritic parental melts produced by extensive melting of a mantle source with recycled crustal components below a thinned lithosphere (50–60 km), within the spinel stability field. The mantle source was dominantly peridotitic, with enriched pyroxenitic domains formed by recycled lower crust, in agreement with previous models for the main tholeiitic STLIP phase. Limited amounts (up to 5%) of highly radiogenic granitoids or moderately radiogenic metapelites were assimilated in upper crustal magma reservoirs. After emplacement, sills intruded in Cambrian evaporites assimilated marlstones and interacted with the evaporitic host rocks, probably via fluids and brines. This is the first time that such process is described in subvolcanic rocks from all across the volcanic basin. The sills are correlated geochemically with the established chemostratigraphy for the on-craton STLIP lava piles and intrusions (Norilsk region). Sills correlated with the Morongovsky–Mokulaevsky Fm. and the Norilsk-type intrusions are the most voluminous, present all across the central Tunguska Basin, and bear the strongest evidence of interaction with evaporites. Massive discharge of thermogenic volatiles is suggested by explosive pipes and hydrothermal vent structures throughout the Tunguska Basin. We propose that this voluminous pulse of magmatism is a good candidate for the hitherto unidentified early intrusive phase of the STLIP, and may link the deep Tunguska basin sills to the end-Permian environmental crisis.
Power-law bounds for critical long-range percolation below the upper-critical dimension
Authors: Hutchcroft Tom 
Published: June 2021

AbstractWe study long-range Bernoulli percolation on $${\mathbb {Z}}^d$$

Z

d

in which each two vertices x and y are connected by an edge with probability $$1-\exp (-\beta \Vert x-y\Vert ^{-d-\alpha })$$

1
-
exp
(
-
β
‖
x
-
y

‖

-
d
-
α

)

. It is a theorem of Noam Berger (Commun. Math. Phys., 2002) that if $$0<\alpha <d$$

0
<
α
<
d

then there is no infinite cluster at the critical parameter $$\beta _c$$

β
c

. We give a new, quantitative proof of this theorem establishing the power-law upper bound $$\begin{aligned} {\mathbf {P}}_{\beta _c}\bigl (|K|\ge n\bigr ) \le C n^{-(d-\alpha )/(2d+\alpha )} \end{aligned}$$

P

β
c

(

|
K
|

≥
n

)

≤
C

n

-
(
d
-
α
)
/
(
2
d
+
α
)

for every $$n\ge 1$$

n
≥
1

, where K is the cluster of the origin. We believe that this is the first rigorous power-law upper bound for a Bernoulli percolation model that is neither planar nor expected to exhibit mean-field critical behaviour. As part of the proof, we establish a universal inequality implying that the maximum size of a cluster in percolation on any finite graph is of the same order as its mean with high probability. We apply this inequality to derive a new rigorous hyperscaling inequality $$(2-\eta )(\delta +1)\le d(\delta -1)$$

(
2
-
η
)
(
δ
+
1
)
≤
d
(
δ
-
1
)

relating the cluster-volume exponent $$\delta $$
δ
and two-point function exponent $$\eta $$
η
.
Age-dependent neurological phenotypes in a mouse model of PRRT2-related diseases
Authors: AJ Fay , T McMahon , C Im , C Bair-Marshall , KJ Niesner , H Li , A Nelson , SM Voglmaier , Y-H Fu , LJ Ptáček 
Published: June 2021

AbstractParoxysmal kinesigenic dyskinesia is an episodic movement disorder caused by dominant mutations in the proline-rich transmembrane protein PRRT2, with onset in childhood and typically with improvement or resolution by middle age. Mutations in the same gene may also cause benign infantile seizures, which begin in the first year of life and typically remit by the age of 2 years. Many details of PRRT2 function at the synapse, and the effects of mutations on neuronal excitability in the pathophysiology of epilepsy and dyskinesia, have emerged through the work of several groups over the last decade. However, the age dependence of the phenotypes has not been explored in detail in transgenic models. Here, we report our findings in heterozygous and homozygous Prrt2 knockout mice that recapitulate the age dependence of dyskinesia seen in the human disease. We show that Prrt2 deletion reduces the levels of synaptic proteins in a dose-dependent manner that is most pronounced at postnatal day 5 (P5), attenuates at P60, and disappears by P180. In a test for foot slippage while crossing a balance beam, transient loss of coordination was most pronounced at P60 and less prominent at age extremes. Slower traverse time was noted in homozygous knockout mice only, consistent with the ataxia seen in rare individuals with biallelic loss of function mutations in Prrt2. We thus identify three age-dependent phenotypic windows in the mouse model, which recapitulate the pattern seen in humans with PRRT2-related diseases.
MR-gestützte stereotaktische Laserthermoablation eines hypothalamischen Hamartoms bei einer jungen Epilepsiepatientin: klinischer Verlauf und Kostenanalyse
Authors: Kohlhase Konstantin , Strzelczyk Adam , Porto Luciana , Beißel Achim , Curry Daniel J. , Rosenow Felix , Schubert-Bast Susanne 
Published: June 2021

Zusammenfassung
Einleitung
Die stereotaktische Laserthermoablation (SLTA) stellt eine minimal-invasive Behandlung für therapierefraktäre Epilepsien auf dem Boden eines hypothalamischen Hamartoms (HH) dar. Durch die weitreichenden Folgen einer therapierefraktären Epilepsie können hohe direkte Kosten entstehen, die durch eine zu erzielende Anfallsfreiheit gesenkt werden können.

Methoden
Anhand einer Patientin mit einem HH sollen die Auswirkungen einer solchen Erkrankung beleuchtet und der Krankheitsverlauf nach erfolgter SLTA dargestellt werden. Zur Beurteilung der Kosteneffizienz der SLTA wurden die direkten Kosten, basierend auf den Krankenversicherungsdaten der Patientin, über die Versicherungsjahre 2017 bis 2020 analysiert.

Ergebnisse
Bei der Patientin bestand eine hochaktive, medikamentenrefraktäre Epilepsie mit erhöhtem Verletzungsrisiko und zunehmender Verschlechterung der schulischen Leistung und der psychischen Verfassung. Begleitend bestand durch das HH eine Pubertas praecox. Nach SLTA entwickelte die Patientin mit einem Follow-up von 26 Monaten eine vollständige Anfallsfreiheit sowie eine endokrinologische Stabilisierung, sodass die antikonvulsive als auch die hormonelle Medikation im Verlauf beendet werden konnten. Relevante persistierende Komplikationen wurden nicht beobachtet. Die direkten jährlichen Kosten (stationär [ausschließlich der SLTA selbst]/ambulant/Medikamente) reduzierten sich von € 6603 in 2017 und € 12.903 in 2018 auf € 3609 in 2019 und zuletzt € 617 in 2020, was einer Reduktion von bis zu 95 % (2018 gegenüber 2020) entsprach. Zusätzlich konnten die Kosten einer geplanten Integrationsassistenz von schätzungsweise € 18.000/Jahr eingespart werden.

Schlussfolgerung
Die SLTA stellt eine effektive und risikoarme Behandlung von HH dar und führt bereits nach 2 Jahren zu einer relevanten Einsparung der direkten Kosten, was bei der Kosten-Nutzen-Abwägung der SLTA einzubeziehen ist.
Assembling Amazon Fires through English Hashtags. Materializing Environmental Activism within Twitter Networks
Authors: Skill Karin , Passero Sergio , Francisco Marie 
Published: June 2021

AbstractThis paper is about the networks around the fires in the Brazilian Amazon forest during 2019 in tweets with the English hashtags #PrayForAmazonas, #ActForTheAmazon and #AmazonFire. We have studied 2517 tweets. Both the languages and the content of the tweets were taken into consideration to see who is assembled and what discursive elements are used in the framing. Our results indicate that the fires are framed as a global concern, beyond the Brazilian borders, especially as ‘the lungs of the world’. The framing of responsibility for the fires is focused on president Bolsonaro, who is assembled in many tweets, while animals and indigenous people are framed as victims. We conclude that the tweets in English tend to produce more relationships in terms of likes and retweets, in comparison to tweets in Portuguese and Spanish. In addition, the role of politicians and celebrities seems critical in getting traction around a hashtag and making it trending.
Variations in methyl bromide concentration with distance and time during quarantine fumigation
Authors: Park Min-Goo , Hong Young-Seoub , Park Chung Gyoo , Gu Dong-Chul , Mo Hyoung-ho 
Published: June 2021

AbstractMethyl bromide (MB) is a highly toxic and ozone-depleting substance and should be replaced. Worker exposure to high MB concentrations during fumigation has been previously reported. However, variations in MB concentration as a function of distance from fumigated objects or of time after degassing have not been reported so far. In this study, air samples were collected at various distances from fumigated objects (oranges, wood in containers, and wood in tarpaulin) during injection and degassing and analyzed via gas chromatography according to the Occupational Safety and Health Agency method. In addition, MB concentrations were directly measured over time using a gas detector during degassing. Non-linear regression analysis of the logarithmically transformed data indicated a clear decrease in MB concentration with distance as well as time. Non-linear regression models were constructed to describe the decrease in MB concentration with distance from the objects and with time during degassing (P < 0.05 for all models). The results of this study could aid in establishing appropriate safety guidelines, and hence, in preventing risks related to MB exposure.
Product formation during discharge: a combined modelling and experimental study for Li–O$$_2$$ cathodes in LiTFSI/DMSO and LiTFSI/TEGDME electrolytes
Authors: Rauter Michael T. , Augustin Matthias , Spitthoff Lena , Svensson Ann Mari 
Published: June 2021

AbstractLi–air or Li–$$\text{O}_2$$

O
2

batteries are a promising energy storage technology due to the potentially high energy density. However, significant challenges related to reversible charge/discharge of these cells need to be solved. The discharge reaction is generally agreed to proceed via two main routes, which may occur simultaneously. These are the surface mechanism, leading to $$\text{Li}_2\text{O}_2$$

Li
2

O
2

product formation as surface films, or the solution mechanism, with solid particles formed in the pore structure of the cathode. A detailed understanding of the reaction mechanisms and the dynamic performance of the electrodes is key to further improvements. Here, we present a mathematical model for the discharge process, based on porous electrode theory, including effects of reactant transport and kinetic limitations, as well as the continuous change of properties due to the formation of reaction products via the solution mechanism and the surface mechanism. The model describes the dynamic change in the ratio of the surface and solution mechanism as a function of growth of film thickness, in line with recent findings. The model is able to predict the differences in experimentally obtained discharge curves between dimethyl sulfoxide and tetra ethylene glycol dimethyl ether solvents with 1M LiTFSI, with a minimum of free parameters. The model parameters are based on physical characterization of the materials and the electrodes, or determined by fitting to impedance spectra recorded during the discharge. The developed model and the methodology will provide a powerful tool for optimization of such electrodes.
Graphic abstract
Social Exclusion Among Official Language Minority Older Adults: A Rapid Review of the Literature in Canada, Finland and Wales
Authors: Nyqvist Fredrica , Häkkinen Emilia , Renaud Alexandre , Bouchard Louise , Prys Cynog 
Published: June 2021

AbstractIt has been suggested that older adults from minority linguistic and ethnic communities face higher risks of being socially excluded. The aim of this review was, therefore, to explore and review social exclusion studies conducted among official language minority older adults in three countries, namely Canada, Finland and Wales. A rapid review approach was used to review scientific literature in line with six social exclusion domains. The literature searches were made in Finnish, Swedish, English, French and Welsh and were restricted to research published within the timeline of 2001 – September 2019 and yielded 42 articles. The included studies were categorized into three different domains: socioeconomic influences, social participation and societal conditions. Converging and diverging patterns of social exclusion in old age were identified between the linguistic minorities. Linguistic barriers regarding access to health care and receiving health information were common across the three linguistic contexts, whereas exclusion from social participation was noticed amongst the linguistic minorities in Canada and Wales. Some connections between belonging to a linguistic minority and being exposed to a lower socioeconomic status and higher poverty risk were made, however, these findings were not robust across all three countries. The findings indicated that experiences of exclusion could be considered fairly common among linguistic minority older adults. We conclude that the research evidence presented in the review sheds light on issues of social inequality in old age between linguistic majorities and minorities, thus identifying important aspects of social exclusion to guide future research as well as policy and practice.
Comparison in practical applications of crown ether sensor molecules containing an acridone or an acridine unit – a study on protonation and complex formation
Authors: Golcs Ádám , Vezse Panna , Ádám Bálint Árpád , Huszthy Péter , Tóth Tünde 
Published: June 2021

AbstractCrown ethers containing an acridone or an acridine unit are successfully applied opto- and electrochemical cation sensors. The heteroaromatic unit of these macrocycles can be in different forms during the applications, which have a strong influence on the sensing behavior. Moreover, in the case of acridono-macrocycles a prototropic equilibrium takes place upon complexation, which is effected by the physicochemical characteristics. A Pb2+-selective acridono-18-crown-6 ether and its 9-phenylacridino-analogue were used as model compounds for comparing the different forms of the heterocyclic units of these sensor molecules. Since in most practical sensor applications of the fluorescent hosts a non-neutral aqueous medium is present, studies on complexation and signaling were carried out from the aspect of the relationship among protonation, coordinating ability, complex stability and tautomeric equilibrium. A strong interdependence among these factors was found and limitations of using unsubstituted acridino- and acridono-sensor molecules in comparison with their 9-substituted-acridino-analogues were discussed. This study will hopefully serve as a useful standpoint for future development of ionophore-based sensors containing an acridone or an acridine unit.
Reconsidering Empathy: An Interpersonal Approach and Participatory Arts in the Medical Humanities
Authors: Cao Erica L. , Blinderman Craig D. , Cross Ian 
Published: June 2021

AbstractThe decline of empathy among health professional students, highlighted in the literature on health education, is a concern for medical educators. The evidence suggests that empathy decline is likely to stem more from structural problems in the healthcare system rather than from individual deficits of empathy. In this paper, we argue that a focus on direct empathy development is not effective and possibly detrimental to justice-oriented aims. Drawing on critical and narrative theory, we propose an interpersonal approach to enhance empathic capacities that is centered on constructive and transformative interactions which integrates the participatory arts and involves both patients and health professional students. We describe and evaluate a program where patients and students create collaborative, original songs. Interviews and a focus group revealed interactional processes summarized in four themes: reciprocal relationships, interactions in the community, joint goal, and varied collaboration. There was a significant enhancement of positive attitudes about care post-program amongst health professional students. The interpersonal approach may be a preliminary framework for the medical humanities to shift away from a focus on direct empathy development and further towards participatory, co-creative, and justice-oriented approaches to enhance health and thereby empathic capabilities.
Publishing in Small Business Economics: An Entrepreneurship Journal
Authors: Audretsch David B. , Guenther Christina , Lederer Adam 
Published: June 2021

Plain English Summary
Publishing entrepreneurship research is not just important but challenging. Longstanding experts in the field can provide helpful advice. As borders between academic fields blur, research fields are increasingly global in their perspective, knowledge, and findings, thus enabling robust participation in research fields at a scale previously unimaginable. Drawing on the experience, insights, and perspectives of three seasoned editors, we try to reconcile the seemingly incoherent and inherent frustration experienced by researchers, on the one hand, with the very purposeful and self-aware process of at least one scholarly journal, Small Business Economics: An Entrepreneurship Journal, on the other, to provide guidelines and insights to aspiring authors in what they should consider in crafting their research for submission with the goal of publication. In providing this sage council, the paper provides guidance to researchers on the process of publishing their results.
An AI-based auxiliary empirical antibiotic therapy model for children with bacterial pneumonia using low-dose chest CT images
Authors: Zhang Mudan , Yu Siwei , Yin Xuntao , Zeng Xianchun , Liu Xinfeng , Shen ZhiYan , Zhang Xiaoyong , Huang Chencui , Wang Rongpin 
Published: June 2021

Abstract
Purpose
To construct an auxiliary empirical antibiotic therapy (EAT) multi-class classification model for children with bacterial pneumonia using radiomics features based on artificial intelligence and low-dose chest CT images.

Materials and methods
Data were retrospectively collected from children with pathogen-confirmed bacterial pneumonia including Gram-positive bacterial pneumonia (122/389, 31%), Gram-negative bacterial pneumonia (159/389, 41%) and atypical bacterial pneumonia (108/389, 28%) from January 1 to June 30, 2019. Nine machine-learning models were separately evaluated based on radiomics features extracted from CT images; three optimal submodels were constructed and integrated to form a multi-class classification model.

Results
We selected five features to develop three radiomics submodels: a Gram-positive model, a Gram-negative model and an atypical model. The comprehensive radiomics model using support vector machine method yielded an average area under the curve (AUC) of 0.75 [95% confidence interval (CI), 0.65–0.83] and accuracy (ACC) of 0.58 [sensitivity (SEN), 0.57; specificity (SPE), 0.78] in the training set, and an average AUC of 0.73 (95% CI 0.61–0.79) and ACC of 0.54 (SEN, 0.52; SPE, 0.75) in the test set.

Conclusion
This auxiliary EAT radiomics multi-class classification model was deserved to be researched in differential diagnosing bacterial pneumonias in children.
Transcatheter mitral valve repair in proportionate and disproportionate functional mitral regurgitation—insights from a small cohort study
Authors: Ooms J. F. , Geleijnse M. L. , Spitzer E. , Ren B. , Van Wiechen M. P. , Hokken T. W. , Daemen J. , de Jaegere P. P. T. , Van Mieghem N. M. D. A. 
Published: June 2021

Abstract
Background
Functional mitral regurgitation (FMR) can be subclassified based on its proportionality relative to left ventricular function and end-diastolic volume. FMR proportionality could help identify responders to transcatheter edge-to-edge mitral valve repair (MitraClip) in terms of residual FMR and/or clinical improvement.

Methods
This single-centre retrospective cohort study evaluated the feasibility of determining FMR proportionality in symptomatic heart failure patients with reduced left ventricular function who were treated with MitraClip for ≥ moderate-to-severe FMR. Baseline proportionate (pFMR) and disproportionate FMR (dFMR) were distinguished. Patient characteristics and MitraClip procedural outcomes were described.

Results
From an overall cohort of 81 eligible FMR patients, 23/81 (28%) had to be excluded due to missing transthoracic echocardiogram parameters, 22/81 were excluded based on FMR severity. The remaining cohort, of 36/81 patients (44%), could be classified into dFMR (n = 26) or pFMR (n = 10). Conduction disorders were numerically increased in dFMR. All cases requiring > 2 clips were in the dFMR group and absence of FMR reduction occurred more frequently with dFMR.

Point of view/Conclusion
Important limitations in terms of imaging acquisition affect the translation of the FMR proportionality concept to a real-world data set. We did observe different demographic and FMR response patterns in patients with proportionate and disproportionate FMR that warrant further investigation.
The Five Diamond Method for Explorative Business Process Management
Authors: Grisold Thomas , Groß Steven , Stelzl Katharina , vom Brocke Jan , Mendling Jan , Röglinger Maximilian , Rosemann Michael 
Published: June 2021

AbstractExplorative business process management (BPM) is attracting increasing interest in the literature and professional practice. Organizations have recognized that a focus on operational efficiency is no longer sufficient when disruptive forces can make the value proposition of entire processes obsolete. So far, however, research on how to create entirely new processes has remained largely conceptual, leaving it open how explorative BPM can be put into practice. Following the design science research paradigm and situational method engineering, we address this research gap by proposing a method called the Five Diamond Method. This method guides explorative BPM activities by supporting organizations in identifying opportunities from business and technology trends and integrating them into business processes with novel value propositions. The method is evaluated against literature-backed design objectives and competing artifacts, qualitative data gathered from BPM practitioners, as well as a pilot study and two real-world applications. This research provides two contributions. First, the Five Diamond Method broadens the scope of BPM by integrating prescriptive knowledge from innovation management. Second, the method supports capturing emerging opportunities arising from changing customer needs and digital technologies.