bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related quality of life and disability in adults with juvenile idiopathic arthritis: comparison with adult-onset rheumatic diseases
Authors: Oliveira Ramos Filipa , Rodrigues Ana , Magalhaes Martins Fernando , Melo Ana Teresa , Aguiar Francisca , Brites Luisa , Azevedo Soraia , Duarte Ana Catarina , Furtado Carolina , Mourão Ana Filipa , Sequeira Graça , Cunha Inês , Figueira Ricardo , Melo Gomes Jose Antonio , Santos Maria Jose , Fonseca Joao Eurico 
Published: November 2021

ObjectiveTo compare physical disability, mental health, fatigue and health-related quality of life (HRQoL) across juvenile idiopathic arthritis (JIA) categories in adulthood and between JIA and adult-onset rheumatic diseases.MethodsCross-sectional analysis nested in a cohort of adult patients with JIA registered in the Rheumatic Diseases Portuguese Register (Reuma.pt). Physical disability (Health Assessment Questionnaire—Disability Index), mental health symptoms (Hospital Anxiety and Depression Scale), fatigue (Functional Assessment of Chronic Illness Therapy—Fatigue Scale (FACIT-F)) and HRQoL (EuroQol-5D (EQ5D) and Short Form (SF-36)) were compared across JIA categories. Patients with polyarticular JIA and enthesis-related arthritis (ERA) JIA were compared respectively to patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA), matched for gender and age, adjusted for disease duration and activity.Results585 adult patients with JIA were included. Comparison across JIA categories showed that persistent oligoarthritis and patients with ERA reported a higher score in EQ5D and SF-36 physical component when compared with other JIA categories.Polyarticular JIA reported less disability and fatigue than patients with RA (median Health Assessment Questionnaire of 0.25 vs 0.63; p<0.001 and median FACIT-F score 42 vs 40 ; p=0.041). Polyarticular JIA had also better scores on EQ5D and all domains of SF-36, than patients with RA. Patients with ERA reported less depression and anxiety symptoms (0% vs 14.8%; p=0.003% and 9% vs 21.3%; p=0.002) and less fatigue symptoms (45 vs 41; p=0.01) than patients with SpA.ConclusionPersistent oligoarticular JIA and ERA are the JIA categories in adulthood with better HRQoL. Overall, adult polyarticular and patients with ERA JIA have lower functional impairment and better quality-of-life than patients with RA and SpA.
Three-month and six-month outcomes of patients with COVID-19 associated hyperinflammation treated with short-term immunosuppressive therapy: follow-up of the CHIC study
Authors: Janssen Marlou THF , Ramiro Sofia , Mostard Rémy LM , Magro-Checa Cesar , Landewé Robert BM 
Published: November 2021

ObjectivesTo prospectively investigate differences in medium-term patient-reported outcome measures and objective functional outcome measures, between patients receiving and those not receiving intensive short-term immunosuppressive therapy for coronavirus disease 19 (COVID-19)-associated hyperinflammation.MethodsPatients previously included in the COVID-19 High-intensity Immunosuppression in Cytokine storm syndrome (CHIC) study who received immunosuppressive treatment versus standard of care for COVID-19-associated hyperinflammation were invited for follow-up at 3 and 6 months after hospitalisation. At both visits, patients were assessed by a pulmonologist, completed quality of life (QoL) questionnaires and performed pulmonary and exercise function tests. At 3 months, patients additionally completed questionnaires on dyspnoea, anxiety, depression and trauma. Outcomes were compared between patients receiving and those not receiving intensive short-term immunosuppressive therapy for COVID-19-associated hyperinflammation.Results131 (66.5%) patients survived hospitalisation due to COVID-19-associated hyperinflammation and 118 (90.1%) were included. QoL questionnaires, pulmonary- and exercise function tests showed improvement between 3 and 6 months after discharge, which was similar in both groups. Assessed patients reached levels that were close to levels predicted from the normal population. In contrast, diffusing capacity of the lung for carbon monoxide was disturbed in both groups: 69.6% predicted (SD 16.2) and 73.5% predicted (SD 16.5) in control group and treated group, respectively.ConclusionsNo differences in medium-term outcomes are demonstrated in survivors of COVID-19-associated hyperinflammation treated or not treated with methylprednisolone with or without tocilizumab during the acute phase. Short-term benefits of this therapy, as showed in the baseline CHIC study analysis, are thus not hampered by medium-term adverse events.
Particle physics in cosmic rays
Authors: Góra Dariusz 
Published: November 2021

The Pierre Auger Observatory is the world’s largest detector of ultra-high energy cosmic rays (UHECRs). It uses an array of fluorescence telescopes and particle detectors at the ground to obtain detailed measurements of the energy spectrum, mass composition and arrival directions of primary cosmic rays (above the energy of [Formula: see text] eV) with accuracy not attainable until now. Observations of extensive air showers performed by the Pierre Auger Observatory can also be used to probe hadronic interactions at high energy, in a kinematic and energy region not accessible by man-made accelerators. Indeed, exploiting Auger data, we reach center-of-mass energies up to 400 TeV, i.e. more than 30 times of those attainable at the Large Hadron Collider (LHC), and explore interactions in the very forward region of phase space on targets of atomic mass of 14. In addition, a precise measurement of the muon component of air showers at the ground is more sensitive to the details of the hadronic interactions along many steps of the cascade development, such as the multiplicity of the secondaries and the fraction of electromagnetic component with respect to the total signal. On the other hand, the intrinsic muon fluctuations mostly depend on the first interaction. In this paper, we overview the new Auger studies exploring the connection between the dynamics of the air shower and the multi-particle production, and how this knowledge can be translated into constraints of the high-energy hadronic models as well as direct measurements, complementary to, and beyond the reach of, accelerator experiments.
New material for Peleserphidae (Proctotrupoidea, Hymenoptera) in Mid-Cretaceous Burmese (Kachin) amber
Authors: Yu Yu , Hu Guifang , Zhu Yunyang , Li Yuxiao , Jiang Wenjun , Rasnitsyn Alexandr P. , Zhang Haichun , Zhang Qi 
Published: November 2021

Abstract

A new female wasp from Cenomanian Burmese amber was described as
Peleserphus qufuensis
sp. nov. in the proctotrupoid family Peleserphidae, which emerged in the Late Jurassic–mid-Cretaceous. It provides new data on the diversity of the family in Cenomanian Burmese amber and extends the records to five species.
Splicing-Mediated Antigen Escape from Immunotherapy for B-cell Malignancies
Authors: Bourcier Jessie , Abdel-Wahab Omar 
Published: November 2021

Summary:In this issue of Blood Cancer Discovery, Zheng and colleagues identify that alternative RNA splicing of CD22 within B-cell acute lymphoblastic leukemia can result in antigen escape from CD22-targeted immunotherapies. Drug-resistant isoforms of CD22 exist within leukemic cells pretreatment and can influence response to the CD22-directed antibody–drug conjugate inotuzumab ozogamicin, the immunotoxin moxetumomab pasudotox, as well as anti-CD22 chimeric antigen receptor T cells.See related article by Zheng et al., p. 103 (7).
Functional connectivity–based prediction of global cognition and motor function in riluzole-naive amyotrophic lateral sclerosis patients
Authors: Wei Luqing , Baeken Chris , Liu Daihong , Zhang Jiuquan , Wu Guo-Rong 
Published: November 2021

Abstract
Amyotrophic lateral sclerosis (ALS) is increasingly recognized as a multisystem disorder accompanied by cognitive changes. To date, no effective therapy is available for ALS patients, partly due to disease heterogeneity and an imperfect understanding of the underlying pathophysiological processes. Reliable models that can predict cognitive and motor deficits are needed to improve symptomatic treatment and slow down disease progression. This study aimed to identify individualized functional connectivity–based predictors of cognitive and motor function in ALS by using multiple kernel learning (MKL) regression. Resting-state fMRI scanning was performed on 34 riluzole-naive ALS patients. Motor severity and global cognition were separately measured with the revised ALS functional rating scale (ALSFRS-R) and the Montreal Cognitive Assessment (MoCA). Our results showed that functional connectivity within the default mode network (DMN) as well as between the DMN and the sensorimotor network (SMN), fronto-parietal network (FPN), and salience network (SN) were predictive for MoCA scores. Additionally, the observed connectivity patterns were also predictive for the individual ALSFRS-R scores. Our findings demonstrate that cognitive and motor impairments may share common connectivity fingerprints in ALS patients. Furthermore, the identified brain connectivity signatures may serve as novel targets for effective disease-modifying therapies.
An Afrasian Entanglement
Authors: Padayachee Kanya 
Published: November 2021

Abstract
The establishment of the Phoenix Settlement and the Gandhi Development Trust (GDT) in South Africa was an experiment in self-sufficient communal living and the promotion of the values and principles of Mahatma Gandhi and South Africa’s democratic Constitution, respectively. While both entities are the result of Gandhi’s South African connection, they serve to embody, through the Mahatma, an Afrasian Entanglement. Gandhi’s time in South Africa made a remarkable impact on him and the country, transforming his political and social positions and influencing its struggle for freedom. In post-apartheid South Africa, the shared mission of both organisations is to advance a culture of nonviolence, peace and social responsibility through a range of transformative programmes. This article details Gandhi’s South African journey, his evolving ideas of passive resistance and social reconstruction there, and the resultant legacy programmes that resonate with the spirit of Ubuntu and the South African Constitution to reinforce democracy.
Spaces and Faces
Authors: Shirodkar Preeti 
Published: November 2021

Abstract
Diasporic writing has been gaining prominence as a genre in recent times. If one were to consider what holds the attention of the audience in this genre, one could narrow it down to its concern with identity and identification as also its recording of an alternate history, which would have otherwise been suppressed and forgotten. Among these writers a significant name is M.G. Vassanji who through his prolific writing explores these alternative histories dispersed across spaces. Considering himself at home in all the places he has lived in and those that are a part of his heritage, he speaks about diasporics, as those that are condemned to remain on the fringes. Complementing/complicating these are his affiliations, some of which he was born into and others which he has acquired. This paper explores the many faces that he claims, or those that have been attributed to him.
The Indian Freedom Struggle and the Kenyan Diaspora
Authors: Nowrojee Pheroze 
Published: November 2021

Abstract
The connections between the Indian Freedom movement and the Kenyan Indian diaspora after the First World War led to the involvement of the Indian National Congress and Gandhi in the struggle of the Kenyan Indians for equality and equal treatment with the British white settlers in Kenya. The Congress considered that the success of the equality struggle in Kenya would also lead to equal treatment of Indians in India itself. This was consistent with the prevailing political goal of the freedom movement in India in 1919, which was self-rule through Dominion Status under the British Crown. But when the struggle of the Kenya Indians failed and equality was denied to them by the famous Devonshire Declaration in 1923, there the Indian freedom movement realized that this signalled unequal status and a denial of self-rule to India itself. Historic consequences followed. This was the turning point and over the years immediately after the Kenyan decision (1923–1929), the Indian National Congress changed its political aim from Dominion Status to Full Independence as a Republic, realized over the 17 years to 1947.
From Marrakesh to Glasgow: Looking Backward to Move Forward on Emissions Trading
Authors: Benjamin Lisa , Wirth David A. 
Published: November 2021

Abstract
The Paris Rulebook—nearly complete, but with the ‘markets’ text tied to Article 6 of the Paris Agreement unadopted after nearly three years—invites comparison with a similar effort under the Kyoto Protocol: the Marrakesh Accords. This article compares the Paris Rulebook and the 2001 Marrakesh Accords implementing the Kyoto Protocol as a way of exploring the similarities and differences in regulatory design between the two sub-regimes and their implications for sustainability and climate integrity. An in-depth analysis of the negotiating history and the text of the two instruments yields trenchant and perhaps unexpected conclusions. Issues that plagued the Marrakesh Accords also appear in similar form in the Paris Rulebook discussions around Article 6; however, because of the difference in structure between the two treaties, even more complex issues have arisen in the Rulebook negotiations. The article reflects on the fundamentally different purpose of the ‘markets’ text in the Rulebook in comparison with its Kyoto/Marrakesh precursor, as well as on the implications of those differences for the Article 6 negotiations.
Religious Freedom in Contest
Authors: Bhat M. Mohsin Alam 
Published: November 2021

Abstract
Legal regulation of religious conversion has become one of the central human rights issues worldwide. Numerous countries, especially in South Asia, have enacted laws that prohibit proselytizating on the grounds of force, allurement, and misrepresentation. Critics have consistently relied on freedom of religion to oppose these laws, but courts in these jurisdictions have upheld them on the very grounds of religious freedom. The present Article explains the historical and ideological bases of this counterintuitive approach to religious freedom by focusing on the case of India. It argues that this approach is based on a historically evolving conception of religion associated with modern Hinduism, according to which all religions have an equal claim to spiritual truth. This precept of religious equality has come to constitute the political and judicial approach to religious freedom and religious conversion laws. The Article uses this interpretive insight to renew the normative critique of such laws.
Passive Proselytism
Authors: Carpenter Christine 
Published: November 2021

Abstract
Article 9 of the European Convention on Human Rights protects the right to freedom of religion and conscience. The language of Article 9(1) has been interpreted by the European Court of Human Rights as including protections for acts of proselytism, when properly committed and respectful of the rights and freedoms of others. This was the view taken in the foundational Article 9 case of the Court, Kokkinakis v. Greece. In the decades since Kokkinakis, however, the view of the Court on proselytism appears to have shifted, in particular in Article 9 cases involving religious garments. This article seeks to determine whether the Court is consistent in its views on proselytism between these religious garment cases and earlier examples of Article 9 case law.
Darwin wasps of the subfamily Pimplinae (Hymenoptera: Ichneumonidae) of Mexico: genera Apechthis Förster, Itoplectis Förster and Pimpla Fabricius
Authors: KHALAIM ANDREY I. , RUÍZ-CANCINO ENRIQUE 
Published: November 2021

Mexican species of three pimpline genera, Apechthis Förster (one species), Itoplectis Förster (six species) and Pimpla Fabricius (20 species, including one unidentified taxon), are reviewed. Four species of Pimpla are described as new to science: P. chamela sp. nov., P. oaxacana sp. nov., P. tequila sp. nov. and P. xalapana sp. nov. Pimpla thoracica Morley, 1914 is found to be a junior synonym of P. ellopiae Harrington, 1892 (syn. nov.). Apechthis zapoteca (Cresson) is recorded for the first time from Venezuela, Pimpla dimidiata (Townes) from Mexico, P. caeruleata Cresson, P. croceiventris (Cresson), P. sanguinipes Cresson and P. sumichrasti Cresson from Honduras, P. ichneumoniformis Cresson and P. viridescens Morley from Guatemala and Honduras, and P. punicipes Cresson from Panama. The South American species Pimpla caerulea Brullé and the Nearctic species P. pedalis Cresson are excluded from the Mexican fauna. Male of Itoplectis mexicana and female of Pimpla dimidiata are recorded for the first time. Identification keys to the species of Itoplectis and Pimpla occurring in Mexico are provided.
Dynamics of the Cloud–Environment Interface and Turbulence Effects in an LES of a Growing Cumulus Congestus
Authors: Strauss Clément , Ricard Didier , Lac Christine 
Published: November 2021

AbstractA giga-large-eddy simulation of a cumulus congestus has been performed with a 5-m resolution to examine the fine-scale dynamics and mixing on its edges. At 5-m resolution, the dynamical production of subgrid turbulence clearly dominates over the thermal production, whereas the situation is reversed for resolved turbulence, the tipping point occurring near the 250-m scale. For cloud dynamics, the toroidal circulation already obtained in previous observational and numerical studies remains, with a strong signature on the resolved turbulent fluxes, the most important feature for the exchanges between the cloud and its environment even though numerous smaller eddies are also well resolved. The environment compensates for the upward mass flux through a large-scale compensating subsidence and the so-called subsiding shell composed of cloud-edge downdrafts, both having a significant contribution. A partition is used to characterize the dynamics, buoyancy, and turbulence of the inner and outer edges of the cloud, the cloud interior, and the far environment. On the edges of the cloud, downdrafts caused by the eddies and by evaporative cooling effects coexist with a buoyancy reversal while the cloud interior is mostly rising and positively buoyant. An alternative simulation in which evaporative cooling is suppressed indicates that this process reinforces the downdrafts near the edges of the cloud and causes a general decrease of the convective circulation. Evaporative cooling also has an impact on the buoyancy reversal and on the fate of the engulfed air inside the cloud.
Genesis of Upper-Tropospheric Anticyclones over the Asian–Western Pacific Sector from Tropical–Extratropical Interaction Perspective
Authors: Ueda Hiroaki , Kuramochi Masaya , Takaya Koutarou , Takaya Yuhei , Asano Saki , Maeda Shuhei 
Published: November 2021

Abstract
Upper-tropospheric anticyclones (UTACs) emerge throughout the seasons with changing location and intensity. Here, the formation mechanisms of these UTACs, especially in the Asian–Australian–western Pacific sector, were investigated based on the diagnosis of the vorticity equation as well as the contribution of the planetary waves. During June–July–August (JJA), a vigorous UTAC corresponding to the South Asian high (SAH) forms over South Asia, to the south of the Tibetan Plateau, where intense heating associated with the Asian summer monsoon rainfall and the resultant baroclinic Rossby response are the important physical processes. Meanwhile, the produced anticyclonic vorticity is farther transported by the interhemispheric divergent wind toward the Southern Hemisphere (SH), creating the SH UTAC centered over the Maritime Continent. During December–January–February (DJF), two zonally elongated UTACs reside on each side of the equator (∼10° poleward), mainly over the Maritime Continent–western Pacific sector. Upon a closer look at the NH winter, we observed that the northern parts of UTAC cannot be explained by this vorticity balance alone. Diagnosis of the wave activity flux indicated that planetary waves emanating from the cold Eurasian continent converges around the northern parts of the UTAC with its peak in the NH winter, which weakens the subtropical jet, thus generating UTAC. Configuration of the SH summer (DJF) UTAC bears resemblance with that of SAH. These results suggest that the creation of anticyclonic vorticity and its interhemispheric transportation as well as the propagation of planetary wave are the selectively important agents for the genesis of seasonally varying UTACs.

Significance Statement
Recent studies have provided evidence that the South Asian high (formerly Tibetan high) is not a purely thermally driven system only maintained over the elevated Tibetan Plateau. This study aims to understand the physical processes responsible for the genesis of the upper-tropospheric anticyclone, especially in the Asian–Australian–western Pacific sector, throughout the season. During summer in the Northern Hemisphere, deep heating caused by South Asian monsoon rainfall plays a crucial role in the genesis of the South Asian high. The wintertime anticyclone emerging over the subtropical western North Pacific is caused via remote influences anchored with tropical convection and the cold Eurasian continent in which atmospheric teleconnections are important. These findings provide new avenues for research on tropical–extratropical interactions with respect to the formation and variability of important climate phenomena.
Mechanisms Determining Diversity of ENSO-Driven Equatorial Precipitation Anomalies
Authors: Yan Zixiang , Wu Bo , Li Tim , Tan Guirong 
Published: November 2021

Abstract
The longitudinal location of precipitation anomalies over the equatorial Pacific shows a distinctive feature with the westernmost location for La Niña, the easternmost location for eastern Pacific (EP) El Niño, and somewhere between for central Pacific (CP) El Niño, even though the center of the sea surface temperature anomaly (SSTA) for La Niña is located slightly east of that of CP El Niño. The mechanisms for such a precipitation diversity were investigated through idealized model simulations and moisture and moist static energy budget analyses. It is revealed that the boundary layer convergence anomalies associated with the precipitation diversity are mainly induced by underlying SSTA through the Lindzen–Nigam mechanism, that is, their longitudinal locations are mainly controlled by the meridional and zonal distributions of the ENSO SSTA. The westward shift of the precipitation anomaly center during La Niña relative to that during CP El Niño is primarily caused by the combined effects of nonlinear zonal moist enthalpy advection anomalies and the Lindzen–Nigam mechanism mentioned above. Such a zonal diversity is further enhanced by the “convection–cloud–longwave radiation” feedback, the SST-induced latent heat flux anomalies, and the advection of mean moist enthalpy by anomalous winds. This diversity in the longitudinal location of precipitation anomalies has contributions to the diversities in the longitudinal locations of anomalous Walker circulation and western North Pacific anomalous anticyclone/cyclone among the three types of ENSO.