bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward transparency of hybrid open access through publisher‐provided metadata: An article‐level study of Elsevier
Authors: Jahn Najko , Matthias Lisa , Laakso Mikael 
Published: July 2021

AbstractWith the growth of open access (OA), the financial flows in scholarly journal publishing have become increasingly complex, but comprehensive data on and transparency of these flows are still lacking. The opacity is especially concerning for hybrid OA, where subscription‐based journals publish individual articles as OA if an optional fee is paid. This study addresses the lack of transparency by leveraging Elsevier article metadata and provides the first publisher‐level study of hybrid OA uptake and invoicing. Our results show that Elsevier's hybrid OA uptake has grown steadily but slowly from 2015 to 2019, doubling the number of hybrid OA articles published per year and increasing the share of OA articles in Elsevier's hybrid journals from 2.6 to 3.7% of all articles. Further, we find that most hybrid OA articles were invoiced directly to authors, followed by articles invoiced through agreements with research funders, institutions, or consortia, with only a few funding bodies driving hybrid OA uptake. As such, our findings point to the role of publishing agreements and OA policies in hybrid OA publishing. Our results further demonstrate the value of publisher‐provided metadata to improve the transparency in scholarly publishing.
Einsatz des Bauer‐Lift‐Cell‐Verfahrens beim Bauvorhaben Posten in Kopenhagen
Authors: Zimbelmann Jörg , Simson Andreas , Beckhaus Karsten 
Published: July 2021

AbstractFür das Bauvorhaben Posten im Zentrum von Kopenhagen hat die Bauer Spezialtiefbau GmbH im Auftrag der Hercules Fundering insgesamt 35 Stück Bauer Lift Cells ∅ 1300 mm (für Großbohrpfähle D = 1500 mm) sowie 66 Stück Bauer Lift Cells ∅ 1000 mm (für Großbohrpfähle D = 1180 mm) hergestellt, geliefert, montiert und injiziert. Das Projekt wurde seitens Bauer Anfang März 2021 erfolgreich abgeschlossen. Bei Bohrpfahlgründungen mit geringen zulässigen Gesamtsetzungen und/oder geringen zulässigen Differenzsetzungen benachbarter Pfähle können mittels der Bauer Lift Cell der Pfahlfußwiderstand vor Erstellung des Bauwerks aktiviert und derart die später auftretenden Pfahlsetzungen durch deren Vorwegnahme erheblich reduziert werden. Die Bauer Lift Cell ist ein Edelstahl‐Hubkissen, das am unteren Ende des Bewehrungskorbs befestigt wird. Nach ausreichender Erhärtung des Pfahlbetons wird die Bauer Lift Cell unter hohem Druck mit Wasser befüllt und der Pfahlfuß gegen den Pfahlschaft vorgespannt. Der dabei eingesetzte Druck wird für jeden Pfahl individuell festgelegt. Nach der vorgegebenen Druckhaltezeit wird die Wasserfüllung vollständig und drucklos durch einen speziell an die Projekterfordernisse angepassten Zementleim ausgetauscht. Danach wird der Injektionsdruck auch beim Zementleim auf den Vorgabewert erhöht und der Zulauf geschlossen. Nach Erhärten des Zementleims sind Verformungen der Bauer Lift Cell dauerhaft ausgeschlossen – der Pfahlfußwiderstand ist aktiviert.
Bauteildruckfestigkeit bei Stahlbetonstützen aus normal‐ und hochfestem Beton
Authors: Matz Henrik , Empelmann Martin 
Published: July 2021

AbstractDie Betondruckfestigkeit, die bei der Bemessung von Stahlbetonstützen anzusetzen ist, wird in den unterschiedlichen Regelwerken (EC2, EC2+NA, MC10) mit einem Beiwert αcc multipliziert, der neben zeitabhängigen Dauerstandeinflüssen auf der Materialseite (αcc,m) auch einfache bauteilspezifische Effekte (αcc,b) berücksichtigt. Hiermit werden aber die in Stahlbetonstützen vorliegenden speziellen bauteilspezifischen Zusammenhänge (z. B. Einfluss einer Längs‐ und Bügelbewehrung) nicht differenziert erfasst, sodass besonders bei Stahlbetonstützen mit höherfesten Betonen oder hohen Bewehrungsgraden in Bezug auf eine sichere Bemessung Bedenken bestehen. Für eine zuverlässigere Berücksichtigung wird in diesem Beitrag eine Stützendatenbank vorgestellt, mit der zunächst ein pauschaler Bauteilfaktor in Abhängigkeit von der Betondruckfestigkeit identifiziert werden kann. Anschließend werden die bauteilspezifischen Effekte aus dem Geometrie‐ und Bewehrungseinfluss auf die Bauteildruckfestigkeit aufgeschlüsselt und ein Produktansatz zur differenzierten Erfassung des Bauteilfaktors vorgeschlagen.
A new sensor based on thieno[2,3‐b]quinoline for the detection of In3+, Fe3+ and F− by different fluorescence behaviour
Authors: Li Linlin , Shang Xiaodong , Li Bing , Xing Yujing , Liu Yuanying , Yang Xiaofeng , Pei Meishan , Zhang Guangyou 
Published: July 2021

AbstractBased on thieno[2,3‐b]quinoline‐2‐carbohydrazide and salicylaldehyde, a novel fluorescent probe (L) was designed and synthesized. L could be used as a multifunctional sensor to sequentially detect In3+ and Fe3+ through fluorescence enhancement and fluorescence quenching in DMF/H2O buffer solutions. At the same time, L had good anti‐interference ability, which could still detect In3+ and Fe3+ well in the presence of other metal ions. For F−, it could be detected by enhancing the fluorescence change caused by the introduction of Al3+. When other anions were present, the detection of F− would not be interfered. The detection limits of In3+, Fe3+ and F− were 1.16 × 10−10 M, 2.03 × 10−8 M and 7.98 × 10−9 M, respectively. The complexation model and sensing mechanism between L and In3+, Fe3+ and F− were confirmed by calculating structural optimization and energy optimization using Gaussian 09 software.
Antileukemic effects of indigo naturalis constituents by “target constituent knock‐out” coupled with semipreparative liquid chromatography and quadrupole time‐of‐flight mass spectrometry
Authors: Huang Hui , Li Yongning , Dai Yabin , Zhang Yuefen , Lu Qiaomei , Xu Qiaoxin , Zhang Yulin 
Published: July 2021

AbstractA novel approach is presented to identify constituents with antileukemic properties in extracts of Indigo naturalis (Qingdai in Chinese). Target compounds (A+, BC+, and ABC+) that knocked out specific constituents displayed antileukemic effects in a total extract of I. naturalis and negative constituents (A−, BC−, and ABC−) that knocked out target compounds were separated, identified and knocked out by semipreparative liquid chromatography (semipreparative HPLC) and quadrupole time‐of‐flight mass spectrometer. Quantitative methods were used to evaluate the content of each knocked‐out constituent in the total extract (D). Subsequently, interactions between the antileukemic effects of knocked‐out constituents and D were screened and evaluated at the cellular level. Negative constituents including A− (65.47% ± 1.20%), BC− (54.61% ± 2.43%) and ABC− (67.49% ± 3.28%) displayed a greater inhibitory effect than D (47.16% ± 0.072%), which was not knocked out after 24 h of incubation, whereas the target compounds had not superior. Target compounds may have caused an antagonistic effect on the corresponding negative constituents. After 48 h, inhibition of proliferation by D (75.48% ± 3.78%) increased compared with that by negative constituents, whereas the antagonistic effect of target components on negative constituents was diminished. This result may reflect competitive antagonism. Comparing the reactions after 24 and 48 h, the inhibitory ratio of ABC− (79.29% ± 1.22%) in these knocked‐out constituents and D was always the highest. With different concentrations tested after 48 h, ABC− significantly increased the rate of apoptosis on K562 cells (P < 0.01), indicating that in addition to indirubin, tryptanthrin and isorhamnetin, other antileukemic constituents may be present. Our study presents an approach that is a truer reflection of the antileukemic effects of knocked‐out constituents in I. naturalis supported by reference to pharmacodynamic actions and the quality of I. naturalis. The approach may be useful for the analysis of other herbal extracts found in traditional Chinese medicine.
Diverse patient trajectories during cytotoxic chemotherapy: Capturing longitudinal patient‐reported outcomes
Authors: Azad Amee D. , Yilmaz Melih , Bozkurt Selen , Brooks James D. , Blayney Douglas W. , Hernandez‐Boussard Tina 
Published: July 2021

AbstractBackgroundHigh‐value cancer care balances effective treatment with preservation of quality of life. Chemotherapy is known to affect patients’ physical and psychological well‐being negatively. Patient‐reported outcomes (PROs) provide a means to monitor declines in a patients’ well‐being during treatment.MethodsWe identified 741 oncology patients undergoing chemotherapy in our electronic health record (EHR) system who completed Patient‐Reported Outcomes Measurement Information System (PROMIS) surveys during treatment at a comprehensive cancer center, 2013–2018. PROMIS surveys were collected before, during, and after chemotherapy treatment. Linear mixed‐effects models were performed to identify predictors of physical and mental health scores over time. A k‐mean cluster analysis was used to group patient PROMIS score trajectories.ResultsMean global physical health (GPH) scores were 48.7 (SD 9.3), 47.7 (8.8), and 48.6 (8.9) and global mental health (GMH) scores were 50.4 (8.6), 49.5 (8.8), and 50.6 (9.1) before, during, and after chemotherapy, respectively. Asian race, Hispanic ethnicity, public insurance, anxiety/depression, stage III cancer, and palliative care were predictors of GPH and GMH decline. The treatment time period was also a predictor of both GPH and GMH decline relative to pre‐treatment. Trajectory clustering identified four distinct PRO clusters associated with chemotherapy treatment.ConclusionsPatient‐reported outcomes are increasingly used to help monitor cancer treatment and are now a part of care reimbursement. This study leveraged routinely collected PROMIS surveys linked to EHRs to identify novel patient trajectories of physical and mental well‐being in oncology patients undergoing chemotherapy and potential predictors. Supportive care interventions in high‐risk populations identified by our study may optimize resource deployment.Novelty and impactThis study leveraged routinely collected patient‐reported outcome (PROMIS) surveys linked to electronic health records to characterize oncology patients’ quality of life during chemotherapy. Important clinical and demographic predictors of declines in quality of life were identified and four novel trajectories to guide personalized interventions and support. This work highlights the utility of monitoring patient‐reported outcomes not only before and after, but during chemotherapy to help advert adverse patient outcomes and improve treatment adherence.
Clinicopathologic factors that influence prognosis and survival outcomes in men with metastatic castration‐resistant prostate cancer treated with Radium‐223
Authors: Al‐Ezzi Esmail M. , Alqaisi Husam A. , Iafolla Marco A. J. , Wang Lisa , Sridhar Srikala S. , Sacher Adrian G. , Fallah‐Rad Nazanin , Jiang Di M. , Watson Geoffrey A. , Catton Charles N. , Warde Padraig R. , Hamilton Rob J. , Fleshner Neil E. , Zlotta Alexandre R. , Hansen Aaron R. 
Published: July 2021

AbstractBackgroundIn men with metastatic castration‐resistant prostate cancer (mCRPC) with primarily bone metastases, radium‐223 (223Ra) improves overall survival (OS). However, the selection of 223Ra is not guided by specific validated clinicopathologic factors, and thus outcomes are heterogeneous.Patients and methodsThis retrospective survival analysis was performed in men with mCRPC treated with 223Ra at our cancer center. Demographics and disease characteristics were collected. OS was calculated using the Kaplan–Meier method (log‐rank). The potential prognostic factors were determined using both univariable (UVA) and multivariable analysis (MVA) (Cox‐regression) methods.ResultsIn total, 150 patients with a median age of 74 years (52–93) received 223Ra between May 2015 and July 2018, and 58% had 6–20 bone metastases. Ninety‐four (63%) patients received >4 223Ra doses, and 56 (37%) received ≤4. The following pre‐treatment factors were analyzed (median [range]): eastern cooperative oncology group performance status (ECOG PS), (1 [0–3]); Albumin (ALB), (39 g/L [24–47]); alkaline phosphatase (ALP), (110 U/L [35–1633]); and prostate‐specific antigen (PSA), (49 µg/L [0.83–7238]). The median OS for all patients was 14.5 months (95% CI: 11.2–18). These factors were associated with poor survival outcomes in UVA and MVA: ALB <35 g/L, ALP >150 U/L, ECOG PS 2–3, and PSA >80 µg/L. By assigning one point for each of these factors, a prognostic model was developed, wherein three distinct risk groups were identified: good, 0–1 (n = 103); intermediate, 2 (n = 30); and poor risk, 3–4 points (n = 17). The median OS was 19.4, 10.0, and 3.1 months, respectively (p < 0.001).ConclusionsPre‐treatment ALB, ALP, ECOG, and PSA, were significantly correlated with OS and could guide treatment selection for men with mCRPC by identifying those who are most or least likely to benefit from 223Ra. Validation in an independent dataset is required prior to widespread clinical utilization.
Investigation of Mn Promotion on HKUST‐1 Metal‐Organic Frameworks for Low‐Temperature Selective Catalytic Reduction of NO with NH3
Authors: Świrk Katarzyna , Delahay Gérard , Zaki Abdelali , Adil Karim , Cadiau Amandine 
Published: July 2021

AbstractA series of HKUST‐1 supported catalysts (also known as Cu‐BTC, or MOF‐199 [copper(II)‐benzene‐1,3,5‐tricarboxylate]) modified with different loadings of manganese were synthesized and characterized by powder X‐ray diffraction, scanning electron microscopy/energy dispersive spectroscopy, nitrogen sorption, thermogravimetric analysis, and temperature‐programmed desorption with NH3. The structural and textural properties of the solids, compared to the reference support, are preserved as much as possible when the manganese content is not higher than 5.0 wt.%. This allows to obtain effective catalysts at low temperatures (<200 °C) in the selective catalytic reduction of NO with NH3. The highest efficiency is obtained with the catalyst containing 3.75 wt.% of manganese which exhibits NO conversion of 68 % at weight hourly space velocity (WHSV) of 96,000 ml/h g. This performance in NO reduction is recognized to be one of the best in the series of HKUST‐1‐Mnx catalysts. Nevertheless, their narrow temperature window for the working reaction and sensitivity to the presence of water vapor and sulfur dioxide remain a drawback.
Synergistic Effect Between Ca4V4O14 and Vanadium‐Substituted Hydroxyapatite in the Oxidative Dehydrogenation of Propane
Authors: Petit Sarah , Thomas Cyril , Millot Yannick , Averseng Frederic , Brouri Dalil , Krafft Jean‐Marc , Dzwigaj Stanislaw , Rousse Gwenaelle , Laberty‐Robert Christel , Costentin Guylène 
Published: July 2021

AbstractThe present work reports on a new type of V‐based catalysts, namely V‐substituted hydroxyapatites, and the influence of the synthesis conditions on their catalytic performance in the oxidative dehydrogenation of propane (ODHP) reaction. Vx‐substituted hydroxyapatite materials prepared with the periodic addition of ammonia during the maturation step (Vx‐HAp‐pH‐per) were shown to exhibit a Ca4V4O14 phase in addition to the V‐substituted hydroxyapatite phase for x greater than or equal to 3.5. TEM characterization of the biphasic samples allowed us to demonstrate that the Ca4V4O14 phase was grown epitaxially on the Vx‐HAp nanorods. The close intimacy between the two phases was confirmed by NMR suggesting the involvement of V4+ species. Consistently EPR data of the fresh and spent samples showed that V4+ species may be stabilized at the boundaries of these two phases. The strong promotion of the oxidative dehydrogenation reaction to propene observed from 723 K for the V4‐HAp‐pH‐per composition is attributed to a synergistic effect between the Vx‐HAp nanorods that enable the activation of propane and the Ca4V4O14 phase that helps the redox exchanges. This synergy may be attributed to an easier electron delocalization on the V4O14 units located at the phases’ boundaries.
Optimization and Engineering of Fatty Acid Photodecarboxylase for Substrate Specificity
Authors: Santner Paul , Szabó László Krisztián , Chanquia Santiago Nahuel , Merrild Aske Høj , Hollmann Frank , Kara Selin , Eser Bekir Engin 
Published: July 2021

AbstractFatty acid photodecarboxylase (FAP) is one of the few photoenzymes in nature. The ability of FAP to convert fatty acids into alka(e)nes without the need for reducing equivalents put this enzyme into spotlight for biocatalytic applications. Although it has been discovered only a few years ago, many studies already emerged demonstrating its potential in areas from biofuel production and enzymatic kinetic resolution to being a critical component of multi‐enzyme cascades. While there have been few protein engineering studies for modulating activity of FAP towards very short chain fatty acids, no study has yet addressed substrate selectivity within the medium to long chain fatty acid range, where FAP shows great promise for the synthesis of drop‐in biofuels from ubiquitous fatty acids with chain lengths from C12 to C18. Here, after determining optimum expression and assay conditions for FAP, we screened 22 rationally designed mutant enzymes towards four naturally abundant fatty acid substrates; C12 : 0, C16 : 0, C18 : 0 and C18 : 1. Depending on the type of the exchanged amino acid, we observed selectivity shifts towards shorter or longer chains, compared to wild type enzyme. Notably, we obtained two groups of mutants; one group with high selectivity towards only C18 : 0, and another group that is selective towards C12 : 0 substrate. Moreover, we measured light and thermal stability of the wild type enzyme as well as the light stability of a mutant engineered for selectivity.
H‐type indices with applications in chemometrics I: h‐multiple similarity index
Authors: Xu Lu , Yang Qin , Xu Qingsong 
Published: July 2021

AbstractThe h‐index was originally proposed to measure the impact of individuals' scientific output, based on their number of publications and citations. In this paper, a variant of h‐index was proposed as a multiple similarity measure and its applications in chemometrics were studied. To measure the multiple similarity among a set of variables or objects, both the pairwise similarity and the coverage of high pairwise similarity across variables or objects were considered and measured with the suggested h‐multiple similarity index (HMSI). HMSI was defined as: based on the pairwise similarity (between [0,1]) among all objects in a set, if at most M% of all the pairwise similarity values is no less than M%, then the HMSI value of the batch will be M%. For applications, HMSI was used in three chemometrics problems: (1) to compare the stability of marker selection results by different classification models in metabonomics; (2) to measure the batch consistency of herbal high‐performance liquid chromatography (HPLC) fingerprints; and (3) to evaluate multivariate calibration models based on cross validation. The results indicate that HMSI is a simple, robust, and effective index to measure multiple similarity and useful in chemometrics applications.
Selective Oxygen and Hydrogen Functionalization of the h‐BN/Rh(111) Nanomesh
Authors: Marie Freiberger Eva , Späth Florian , Bauer Udo , Düll Fabian , Bachmann Philipp , Steinhauer Johann , Hemauer Felix , Waleska Natalie J. , Schwaab Valentin , Steinrück Hans‐Peter , Papp Christian 
Published: July 2021

AbstractWe present detailed studies on the covalent adsorption of molecular oxygen and atomic hydrogen on the hexagonal boron nitride (h‐BN) nanomesh on Rh(111). The functionalization of this two‐dimensional (2D) material was investigated under ultra‐high vacuum conditions using synchrotron radiation‐based in situ high‐resolution X‐ray photoelectron spectroscopy, temperature‐programmed X‐ray photoelectron spectroscopy and ultraviolet photoelectron spectroscopy. We are able to provide a deep insight into the adsorption behavior and thermal stability of oxygen and hydrogen on h‐BN/Rh(111). Oxygen functionalization was achieved via a supersonic molecular beam while hydrogen functionalization was realized using an atomic hydrogen source. Adsorption of the respective species was observed to occur selectively in the pores of h‐BN leading to spatially defined modification of the 2D layer. The adsorption of the observed molecular oxygen species was found to be an activated process that requires high‐energy oxygen molecules. Upon heating to 700 K, oxygen functionalization was observed to be almost reversible except for small amounts of boron oxides evolving due to the reaction of oxygen with the 2D material. Hydrogen functionalization of h‐BN/Rh(111) was fully reversed upon heating to about 640 K.
Application Limits of the Ferrioxalate Actinometer**
Authors: Wriedt Benjamin , Ziegenbalg Dirk 
Published: July 2021

AbstractEvaluating the efficiency of newly designed photoreactors is crucial for systematic development and optimization of photochemical processes. A suitable tool is actinometry, prominently represented by the most widely studied and applied ferrioxalate system. However, such measurements show reproducibility problems in the data consistency. This study scrutinizes these issues and approaches an experimental elucidation. An application limit for the ferrioxalate actinometer under intense irradiation was identified and experimentally validated. A drop of the quantum yield at high incident photon fluxes, generating high local concentrations of carboxyl radicals, leads to systematically wrong measurements. For reliable measurements with the ferrioxalate actinometry, a continuous operation mode or extensive mixing should be ensured.
Analysing and measuring the performance of memristive integrating amplifiers
Authors: Wang Jiaqi , Serb Alexantrou , Papavassiliou Christos , Maheshwari Sachin , Prodromakis Themis 
Published: July 2021

AbstractRecording reliably extracellular neural activities is an essential prerequisite for the development of bioelectronics and neuroprosthetic applications. Recently, a fully differential, two‐stage, integrating pre‐amplifier was proposed for amplifying and then digitising neural signals. The amplifier featured a finely tuneable offset that was used as a variable threshold detector. Given that the amplifier is integrating, the DC operating point keeps changing during integration, rendering traditional analysis (AC/DC) unsuitable. In this work, we analyse the operation of this circuit and propose alternative definitions for validating the necessary key performance metrics, including gain, bandwidth, offset tuning range and offset sensitivity with respect to the memory states of the employed memristors. The amplification process is analysed largely through investigating the transient behaviour during the integration phase. This benchmarking approach is finally leveraged for providing useful insights and design trade‐offs of the memristor‐based integrating amplifier.