bluuebunny/crossref_metadata_2025_split huggingface dataset:
Willingness of the owners in the integrated development to establish the subsidiary management corporation
Authors: Liat Choon Tan , Wee Vern Tan , Kam Seng Looi , Liang Toh Ming , Bin Ujang Muhamad Uznir , Azri Suhaibah binti , Ai Chin Thoo , Kathitasapathy Shanmugapathy A.L. 
Published: December 2021

PurposeThe increasing number of strata property in Malaysia promotes the different usages of development under the integrated development, which comprise the different usages of owner groups. These owner groups may not enjoy all the common properties in the integrated development. Therefore, the purpose of this research is to identify the important to designate the limited common property for the owners who have the exclusive benefit on it. However, the establishment of the subsidiary management corporation and limited common property is less popular in Malaysia.Design/methodology/approachHence, research should be carried out to identify the importance of the establishment of the subsidiary management corporation and enhancement for the establishment of subsidiary management corporation to increase the willingness of the owner to establish the subsidiary management corporation. Collective Action Theory likewise assists to increase the willingness of the owner in the establishment of the subsidiary management corporation. A sum of 100 owners in the integrated development and 187 stratified property professionals are the respondents in this research, by applying the random sampling method.FindingsResults indicate the problems that occur in the integrated development is the complexity management in integrated development, followed by the usages of the common property. Therefore, Collective Action Theory could ensure the effectiveness of the establishment of the subsidiary management corporation in the aspect of social rights, resources, governance groups and participants.Originality/valueThis paper provided an overview of the management circumstance in the integrated development of Malaysia and discussed some effective enhancements to promote the sustainable formation of the subsidiary management corporation or two-tier management corporations.
Beyond the police: libraries as locations of carceral care
Authors: Moreno Teresa Helena 
Published: December 2021

PurposeThe purpose of this paper is to make visible the connections libraries have to carceral systems and how library workers replicate carceral behavior through care.Design/methodology/approachThis paper uses interdisciplinary research methods in the fields of library science, criminology, feminist studies, Black studies and abolition to examine the role of libraries as locations of carceral care.FindingsLibraries, through their history and funding as well as their roles within society as educators and social service providers, have the components necessary to act out carceral care; libraries by extension can and do participate in forms of carceral care.Originality/valueThere has been much work on carceral care in the fields of social work and education, but to date, there has been little to no scholarship on how libraries work within the landscape of carceral care. This article builds upon the work of others to help understand how it applies to libraries.
AES presidential address, 2021: Policy analysis for rural resilience—Expanding the toolkit
Authors: Dwyer Janet 
Published: December 2021

AbstractI reflect on the progress of policy analysis for sustainable rural development over my professional lifetime, and the implications for the future. In so doing, I emphasise the distinction between policy analysis and policy evaluation, and the importance of enabling and facilitating transformation to improve resilience in a time of climate crisis; both of which highlight the need for more inclusive analytical tools, concepts and approaches. The central focus is on the development of a conceptual framework which is dynamic, interactive and holistically systemic, elucidated through, especially, comparative case studies and social‐ecological concepts. Recognition of the diversity of contexts and the heterogeneity of individual characters embedded in institutional cultures, which are of our own making, leads to a much richer and more resilient conceptual framework for analysis and effective diagnosis than the abstract and severely reductive textbook economic tradition. Future research priorities for agricultural economists are suggested: in new rural governance, mapping food systems, and enhanced performance assessment for farming businesses. In that context, a call is made for increased labour and skills in future UK farming.
Employee regret and disappointment: Creation of a scale and foundational application of the approach/avoidance framework
Authors: Howard Matt C. , Smith Mickey B. 
Published: December 2021

AbstractA growing number of calls have been made for a discrete‐emotions approach in organisational research, and we answer these calls by theoretically and empirically distinguishing the effects of regret and disappointment by applying the approach/avoidance framework. We predict that regret positively relates to avoidance motivation, whereas disappointment both positively relates to avoidance motivation and negatively relates to approach motivation. We also predict that approach and avoidance motivations mediate the effects of regret and disappointment on employee outcomes, including job satisfaction, organisational citizenship behaviors, voice, counterproductive work behaviors, withdrawal, and turnover intentions. To test these predictions, we conduct five studies to develop theoretically driven and psychometrically sound scales to measure both emotions—the Employee Regret and Disappointment Scales (ERDS). The results of two final studies support the distinct effects of regret and disappointment on important employee outcomes and the mediating effects of approach/avoidance motivations in these relations. We close by discussing the theoretical and practical implications with suggestions for future research.
Choice of oral anticoagulant prescribed by general practices in Wales: Application of Dirichlet regression and linked data
Authors: Hill‐McManus Daniel , Hughes Dyfrig A. 
Published: December 2021

AimsThere has been sustained growth in the prescribing of direct oral anticoagulants (OACs) in primary care in the UK. Given the different indications, properties and prices of OACs, variation between prescribers is expected; however, a high level of variation may be evidence of inappropriate or suboptimal prescribing. This study examined the variation in the relative use of OACs in primary care in Wales.MethodsData on total defined daily doses of all community‐dispensed OACs in 2019 were linked at the GP practice level with disease registers, patient demographic data and GP and patient numbers. The relative use of each OAC, as a fraction of all OACs prescribed, was analysed using Dirichlet regression to quantify the association between prescribing patterns and practice and area‐level characteristics.ResultsAcross 417 GP practices, the mean (range) in the relative prescribing of warfarin was 37% (6%–64%), apixaban was 32% (2%–65%), rivaroxaban 23% (0%–66%), dabigatran 3% (0%–23%) and edoxaban 6% (0%–59%). Statistical modelling provided strong evidence that prescribing patterns are associated with a GP practice's health board and also their nearest major hospital. Compared to the null model, a model including health board resulted in a 15% fall in Akaike information criterion, increasing to 20% with the addition of nearest major hospital and 27% including further covariates.ConclusionSystematic variation in OAC prescribing, by health board and based on nearest hospital, indicates that factors other than patient clinical characteristics and preferences may be influencing prescribing decisions.
Estimating the impacts of payroll taxes: Evidence from Canadian employer–employee tax data
Authors: Deslauriers Jonathan , Dostie Benoit , Gagné Robert , Paré Jonathan 
Published: December 2021

AbstractIn this paper, we use linked employer–employee administrative tax data from Canada to estimate the impact of payroll taxes on a variety of firms’ and workers’ outcomes. For one province, we are able to exploit a policy change in the payroll tax rate to estimate its impact on the firm's level of employment, average wage and average sales, with difference‐in‐differences models, taking into account firm‐level unobserved heterogeneity. Additionally, taking advantage of the nature of linked data, we estimate wage equations with both fixed worker and firm fixed effects. We find no impact on employment and average sales, but significant impacts on wages, implying that payroll taxes are passed almost entirely to workers in the form of lower wages.
Hypoglycemia associated with direct‐acting anti‐hepatitis C virus drugs: An epidemiologic surveillance study of the FDA adverse event reporting system (FAERS)
Authors: Zhou Yu , Xie Wenhuo , Zheng Chenhua , Liu Libin , Chen Zhou , Wang Xiaolu 
Published: December 2021

AbstractBackground and ObjectiveHypoglycemia induced by direct‐acting antiviral agents (DAAs) for chronic hepatitis C virus (HCV) infection is a rare but potentially life‐threatening adverse reaction, which led to warnings by competent authorities. We therefore aimed to examine the hypoglycemic safety signal for DAAs.MethodsReports to the US Food and Drug Administration Adverse Event Reporting System (FAERS) from 1 October 2012 to 31 March 2020 were analyzed. The Medical Dictionary for Regulatory Activities was used to identify hypoglycemia cases. A case by non‐case disproportionality approach was used whereby reporting odds ratio (ROR) with 95% confidence intervals (CI) were calculated.ResultsIn HCV infection with diabetes patients, the cumulative frequency of hypoglycemic ADRs was 21.85/1000 for reports involving DAAs versus 13.50/1000 for reports involving other medications; For DAAs as a class drug, a nearly double increased reporting odds for hypoglycemia was observed (ROR: 1.63, 95% CI: 1.11–2.41). However, in DAAs subgroup analysis, only telaprevir (ROR: 1.66, 95% CI: 1.01–2.74) and elbasvir/grazoprevir (ROR: 2.25, 95% CI: 1.05–4.83) were associated with increased reporting risk of hypoglycemia during corresponding marketing period; when combined with insulins and sulfonylureas, DAAs were associated with increased reporting risk for hypoglycemia (ROR: 1.98, 95% CI: 1.36–2.88; ROR: 1.62, 95% CI: 1.06–2.48), but concomitant biguanides, dipeptidyl peptidase IV (DPP‐4) inhibitors or glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) were not significant.ConclusionsThis study supports the current recommendation for cautious about hypoglycemic risk relating to the use of DAAs. Treatment with DAAs and antidabetic agents (especially insulins and sulfonylureas) will increase hypoglycemia reporting risk. Physicians and pharmacists should be aware of this risk when prescribing DAAs for patients suffering from diabetes, advanced age or liver decompensation.
Donor‐derived cell‐free DNA and renal allograft rejection in surveillance biopsies and indication biopsies
Authors: Chang Jae‐Hyung , Alvarado Verduzco Hector , Toma Katherine , Sritharan Sharlinee , Mohan Sumit , Husain Syed Ali 
Published: December 2021

AbstractTo evaluate the role of circulating dd‐cfDNA in allograft surveillance in immunologically high‐risk patients, a retrospective cross‐sectional study of 261 kidney transplant recipients who underwent outpatient allograft biopsy at our center between September 2020 and August 2021 was performed. Of the 236 dd‐cfDNA results included, 37 samples were obtained at the time of a surveillance biopsy in sensitized recipients and 199 at the time of a clinically indicated biopsy. The median serum creatinine at the time of the biopsy was 1.3 mg/dl and 2.1 mg/dl for surveillance biopsies and clinically indicated biopsies, respectively (P < .001). Rejection was diagnosed in 27% of surveillance biopsies and 29% of clinically indicated biopsies. Among surveillance biopsies, sensitivity and specificity to detect rejection were 0% and 89%, respectively, and among clinically indicated biopsies they were 28% and 96%, respectively. The sensitivity and specificity to detect antibody‐mediated rejection were 0% and 91% among surveillance biopsies and 50% and 94% among clinically indicated biopsies. Nine biopsies without rejection findings had corresponding dd‐cfDNA of ≥1%. Our data does not support dd‐cfDNA as a biomarker for kidney allograft rejection, even in immunologically high‐risk patients in the absence of graft dysfunction.
Target to treatment: A charge to develop biomarkers of response and tolerability in child and adolescent psychiatry
Authors: Stancil Stephani L. , Tumberger John , Strawn Jeffrey R. 
Published: December 2021

AbstractThe current pediatric mental health crisis is characterized by staggering rates of depression, anxiety, and suicide. Beyond this, first‐line pharmacologic interventions for depressive and anxiety disorders in children and adolescents produce variable responses with two in five youths failing to respond. Given the heterogeneity of treatment response in pediatric depressive and anxiety disorders, pharmacodynamic biomarkers are necessary to develop precision therapeutics by identifying clear targets to guide treatment. This mini‐review summarizes candidate biomarkers and their development in pediatric mental health conditions. A framework for how these biomarkers may relate to safety, efficacy (e.g., surrogates for clinical endpoints), tolerability or target engagement (i.e., drug action) in children and adolescents is also presented. Taken together, accumulating data suggest that, in children and adolescents with myriad psychiatric disorders, pharmacodynamic biomarkers could facilitate developing drugs with well‐defined targets in specific populations, could inform treatment decisions, and hasten patients’ recovery.
A quantitative analysis of MDMA seized at New South Wales music festivals over the 2019/2020 season: Form, purity, dose and adulterants
Authors: O'Reilly Matthew J. A. , Harvey Christine A. , Auld Robin , Cretikos Michelle , Francis Catherine , Todd Stephanie , Barry Daniel , Cullinan Una , Symonds Michael 
Published: December 2021

AbstractIntroductionThis research aims to understand the content and nature, and to explore the harm potential, of suspected 3,4‐methylenedioxymethamphetamine (MDMA) substances circulating at music festivals in New South Wales.MethodsAcross 19 music festivals held between October 2019 and March 2020, 302 substances detected and suspected by police to contain MDMA were selected for quantitative analysis.ResultsFive percent of substances contained a drug other than MDMA (n = 13) or no drug (n = 2). The remaining 95.0% (n = 287) contained MDMA. Of this sub‐sample, capsule was the commonest form (83.3%), followed by tablet (7.7%), crystal (6.3%) and powder (2.8%). The median MDMA base‐purity of non‐tablet forms ranged between 73.5% and 75.0%. The median MDMA base‐dose per tablet (116 mg) was higher than per capsule (68 mg). The dose range varied substantially for capsules (14–146 mg) and tablets (24–201 mg). A higher dose (130 mg or greater) was found in 3.5% of MDMA tablets or capsules. Adulterants were identified in 14.1% of MDMA substances but only 1.6% contained a psychoactive adulterant and none presented as dangerous due to their nature or low concentration.Discussion and ConclusionsDangerous MDMA adulterants or new psychoactive substances in tablet, capsule, powder or crystal forms (whether misrepresented as MDMA or not) were unlikely to be in circulation during the study period. Harm reduction messaging should inform that a key risk‐factor for MDMA‐related harm is the high and wide variation of purity and dose across forms. Market changes may have occurred since COVID‐19, but continued monitoring will ensure messaging remains current.
A presystolic wave could easily detect subclinical left ventricular dysfunction in prediabetic patients with no history of hypertension
Authors: Şaylık Faysal , Akbulut Tayyar 
Published: December 2021

AbstractBackgroundPrediabetes is associated with left ventricular (LV) systolic and diastolic dysfunction. A presystolic wave (PSW) is detected on late diastole from the Doppler examination of the LV outflow tract and is related to LV dysfunction. LV dysfunction could be detected with different echocardiographic methods, including conventional Doppler and Tissue Doppler imaging (TDI), 2D speckle tracking echocardiography, and myocardial performance index (MPI). In this study, we aimed to investigate the association of the presence of PSW with LV dysfunction assessed by different echocardiographic methods.MethodsA total of 137 prediabetic normotensive patients were enrolled in this study. Eighty‐one (59.1%) patients had a PSW and 36 (40.9%) patients had not PSW on the Doppler examinations. Echocardiographic features were compared between these groups. LV dysfunction was determined based on MPI, LV global longitudinal strain (LVGLS), and conventional Doppler and TDI measurements.ResultsThere were no differences between groups regarding clinical and laboratory parameters, except LDL, which was significantly higher in the PSW‐positive group. The PSW‐positive group had lower E, Em, Ea, E/A, Em/Am, Ea/Aa, LVGLS and higher A, Am, Aa, E/e’, isovolumetric relaxation time, and MPI than PSW‐negatives. PSW velocity was moderately correlated with MPI (R = .33, p = .003) and LVGLS (R = .35, p = .001). The presence of PSW was independently associated with LV dysfunction assessed by MPI (OR = 3.87, p < .001), LVGLS (OR = 10.29, p < .001), and conventional Doppler and TDI parameters (OR = 8.87, p < .001).ConclusionPSW was significantly associated with subclinical LV dysfunction in prediabetic normotensive patients assessed with three echocardiographic methods.
Early alterations of the neuronal network processing whisker‐related sensory signal during absence epileptogenesis
Authors: Laghouati Emel , Studer Florian , Depaulis Antoine , Guillemain Isabelle 
Published: December 2021

AbstractObjectiveEpileptogenesis is the particular process during which the epileptic network builds up progressively before the onset of the first seizures. Whether physiological functions are impacted by this development of epilepsy remains unclear. To explore this question, we used Genetic Absence Epilepsy Rats From Strasbourg (GAERS), in which spike‐and‐wave discharges are initiated in the whisker primary somatosensory cortex (wS1) and first occur during cortical maturation. We studied the development of both the epileptic and the physiological wS1 circuits during cortical maturation to understand the interactions between them and the consequences for the animals' behavior.MethodsIn sedated and immobilized rat pups, we recorded in vivo epileptic and whisker sensory evoked activities across the wS1 and thalamus using multicontact electrodes. We compared sensory evoked potentials based on current source density analysis. We then analyzed the multiunit activities evoked by whisker stimulation in GAERS and control rats. Finally, we evaluated behavioral performance dependent on the functionality of the wS1 cortex using the gap‐crossing task.ResultsWe showed that the epileptic circuit changed during the epileptogenesis period in GAERS, by involving different cortical layers of wS1. Neuronal activities evoked by whisker stimulation were reduced in the wS1 cortex at P15 and P30 in GAERS but increased in the ventral posteromedial nucleus of the thalamus at P15 and in the posterior medial nucleus at P30, when compared to control rats. Finally, we observed lower performance in GAERS versus controls, at both P15 and P30, in a whisker‐mediated behavioral task.SignificanceOur data show that the functionality of wS1 cortex and thalamus is altered early during absence epileptogenesis in GAERS and then evolves before spike‐and‐wave discharges are fully expressed. They suggest that the development of the pathological circuit disturbs the physiological one and may be responsible for both the emergence of seizures and associated comorbidities.
The Cenozoic history of palms: Global diversification, biogeography and the decline of megathermal forests
Authors: Lim Jun Ying , Huang Huasheng , Farnsworth Alexander , Lunt Daniel J. , Baker William J. , Morley Robert J. , Kissling W. Daniel , Hoorn Carina 
Published: December 2021

AbstractAimMegathermal rain forests and mangroves are much smaller in extent today than in the early Cenozoic, primarily owing to global cooling and drying trends since the Eocene–Oligocene transition (c. 34 Ma). The general reduction of these biomes is hypothesized to shape the diversity and biogeographical history of tropical plant clades. However, this has rarely been examined owing to a paucity of good fossil records of tropical taxa and the difficulty in assigning them to modern clades. Here, we evaluate the role that Cenozoic climate change might have played in shaping the diversity and biogeography of tropical plants through time.LocationGlobal.Time periodCenozoic, 66 Ma to present.Major taxa studiedFour palm clades (Calaminae, Eugeissoneae, Mauritiinae and Nypoideae) and their fossil pollen record.MethodsWe compiled fossil pollen occurrence records for each focal palm lineage to reconstruct their diversity and biogeographical distribution throughout the Cenozoic. We use climatic niche models to project the distribution of climatically suitable areas for each lineage in the past, using palaeoclimatic data for the Cenozoic.ResultsFor most palm lineages examined, global pollen taxonomic diversity declined throughout the Cenozoic. Geographical ranges for each focal lineage contracted globally and experienced regional‐scale extinctions (e.g., Afrotropics), particularly after the Miocene. However, climatic niche models trained on extant species of these focal lineages often predict the presence of climatically suitable habitat in areas where these lineages went extinct.Main conclusionsGlobally, the decline in megathermal rain forest and mangrove extent might have led to declines in diversity and range contractions in some megathermal plant taxa throughout the Cenozoic. Although global climatic trends are an important backdrop for the biogeography and diversity of tropical groups at global scales, their continental‐ or regional‐scale biogeographical trajectories might be more dependent on regional abiotic and biotic contexts.
Media use, positive and negative emotions, and stress levels of adults during COVID‐19 pandemic in Turkey: A cross‐sectional study
Authors: Akca Ayşegül , Ayaz‐Alkaya Sultan 
Published: December 2021

AbstractAimThis study was conducted to determine media use, positive and negative emotions, and stress levels of adults during the COVID‐19 pandemic.BackgroundUsing media tools in the pandemic process has impacted the mental health of individuals. As the COVID‐19 outbreak is a new disease fear, anxiety and stress about this situation can cause strong emotions in adults.MethodsThe research was carried out using a cross‐sectional design. The sample consisted of 1541 adults. The Positive and Negative Emotion Scale, and the Perceived Stress Scale were used to collect the data.ResultsThe Positive Emotion Scale mean scores were lower (p < 0.05) for those people whose daily media use time was more than 4 h and who followed the developments about COVID‐19 through the media once a day. It was found that those with daily media use of more than 4 h/day had higher Perceived Stress Scale scores than those with lower use (p > 0.05).ConclusionThis study concluded that the use of media in adults increased during the COVID‐19 outbreak and that media use was associated with positive and negative emotions and stress levels. Health professionals should assess the effect of the COVID‐19 outbreak on mental health in various community groups and develop interventions to prevent negative consequences of increased media use.