bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methimazole-induced remission rates in pediatric Graves’ disease: a systematic review
Authors: Lieshout Jelmer M van , Mooij Christiaan F , Trotsenburg A S Paul van , Zwaveling-Soonawala Nitash 
Published: June 2021

Objective
Comparison of studies on remission rates in pediatric Graves’ disease is complicated by lack of uniformity in treatment protocols, remission definition, and follow-up duration. We performed a systematic review on remission rates in pediatric Graves’ disease and attempted to create uniformity by recalculating remission rates based on an intention-to-treat analysis.

Methods
PubMed and Embase were searched in August 2020 for studies on patients with Graves’ disease: (i) 2 to 18 years of age, (ii) initially treated with methimazole or carbimazole for at least 18 months, (iii) with a follow-up duration of at least 1 year after cessation of methimazole or carbimazole. All reported remission rates were recalculated using an intention-to-treat analysis.

Results
Of 1890 articles, 29 articles consisting of 24 patient cohorts were included with a total of 3057 patients (82.6% female). Methimazole or carbimazole was initially prescribed in 2864 patients (93.7%). Recalculation based on intention-to-treat analysis resulted in an overall remission rate of 28.8% (829/2880). Pooled remission rates based on treatment duration were 23.7, 31.0, 43.7, and 75% respectively after 1.5–2.5 years, 2.5–5 years, 5–6 years (two studies), and 9 years (single study) treatment duration. The occurrence of adverse events was 419 in 2377 patients (17.6%), with major side effects in 25 patients (1.1%).

Conclusions
Using a standardized calculation, the overall remission rate in methimazole-treated pediatric GD is 28.8%. A few small studies indicate that longer treatment increases the remission rate. However, evidence is limited and further research is necessary to investigate the efficacy of longer treatment durations.
Immunological and mutational analysis of SARS-CoV-2 structural proteins from Asian countries
Authors: Jha Deepak Kumar , Yashvardhini Niti , Kumar Amit 
Published: June 2021

Introduction: The emergence of a novel coronavirus, SARS-CoV-2, an etiolating agent of coronavirus disease (COVID-19), has become a pandemic of global concern. Considering the huge number of morbidity and mortality worldwide, the World Health Organization, on 11th March 2020, has announced an unprecedented public health crisis. This virus is a member of plus sense RNA viruses that can show a high rate of mutations. The ongoing multiple mutations in the structural proteins of coronavirus drive viral evolution, enabling them to evade the host immunity and rapidly acquire drug resistance against COVID-19. In the present study, we focused mainly on the prevalence of mutations in the four types of structural proteins like S (spike), E (envelope), M (membrane), and N (nucleocapsid) that are required for the assembly of a complete virion particle. Further, we estimated the antigenicity and allergenicity of these structural proteins to design and develop a potentially good candidate vaccine against SARS-CoV-2.
Methods: In the present in silico study, envelope protein was found highly antigenic followed by nucleocapsid, membrane, and spike protein of SARS-CoV-2.
Results: Consequently, in this study, we detected 987 mutations from 729 sequences of Asia in October 2020 and compared them with China's 1st Wuhan isolate sequence as a reference. Spike showed the highest mutations with 807 point mutations among the four structural proteins, followed by nucleocapsid with 151 mutations, while envelope showed 19 and membrane only 10 point mutations.
Conclusion: Taken together, our study revealed, variation occurring in the structural protein of SARS-CoV-2 might be altering their structure and functions, and envelope protein appears to be a promising vaccine candidate to curb coronavirus infections.
Changes in the Management of Severe Orbital Infections Over Seventeen Years
Authors: Krueger Carsten , Mahant Sanjay , Begum Nurshad , Widjaja Elysa , Science Michelle , Parkin Patricia C. , Gill Peter J. 
Published: June 2021

OBJECTIVES:
Periorbital and orbital cellulitis are common but serious infections in children. Management of these infections varies because of an absence of clinical guidelines, but it is unclear if management within institutions has changed over time. We compared the management and outcomes of children hospitalized with periorbital and orbital cellulitis in 2 eras.

METHODS:
Data were extracted from records of children hospitalized at a tertiary care children’s hospital with periorbital or orbital cellulitis from 2000 to 2005 and 2012 to 2016. Patient demographics, cross-sectional imaging, antibiotic and corticosteroid use, length of stay, and surgical rates were collected. Data from the eras were compared by using descriptive statistics, t tests, Mann–Whitney U tests, Fisher’s exact tests, and χ2 tests.

RESULTS:
There were 318 children included, 143 from 2000 to 2005 and 175 from 2012 to 2016. Compared with the first era, in the second era there were increased rates of MRI (5% vs 11%, P = .04), although rates of computed tomography scan use remained unchanged (60% vs 65%); increased number (1 vs 3, P &lt; .01) and spectrum of antibiotics; increased use of intranasal corticosteroids (3% vs 49%, P &lt; .01); and subspecialty consultation (89% vs 99%, P = .01). There were no differences in length of stay, readmission, or surgical rates between eras.

CONCLUSIONS:
There has been considerable change in the management of hospitalized children with severe orbital infections at our institution, including the rates of MRI, number and spectrum of antibiotics used, use of adjunctive agents, and increased subspecialty involvement with no observed impact on clinical outcomes. Future research is needed to rationalize antimicrobial therapy and reduce low-value health care.
Visitor Guidelines in US Children’s Hospitals During COVID-19
Authors: Vance Ashlee J. , Duy Joanne , Laventhal Naomi , Iwashyna Theodore J. , Costa Deena K. 
Published: June 2021

OBJECTIVES:
To examine visitor guidelines among children’s hospitals in the United States in response to the coronavirus 2019 (COVID-19) pandemic.

METHODS:
A retrospective assessment of visitor guidelines in 239 children’s hospitals in the United States.

RESULTS:
In this study, we present an analysis of 239 children’s hospital visitor guidelines posted to hospitals’ Web sites during 1 week in June 2020. Of the 239 hospitals, only 28 did not have posted guidelines for review. The guidelines were analyzed and grouped by how the guidelines were updated in response to COVID-19. Parental visitation was restricted to 1 parent in 116 of the posted guidelines (49%). There were no obvious similarities among guidelines associated with their geographical (eg, state or local) location. As of February 2021, 33 of 55 (60%) randomly selected hospitals had not changed their visitor policy since our initial review.

CONCLUSIONS:
The COVID-19 pandemic triggered changes in publicly reported visitor guidelines across the majority of children’s hospitals. With our findings, we suggest wide variation in policies and practices in how guidelines were updated. More work is needed to understand how to optimize public safety and preserve family-centered care and parental authority in times of crisis.
Nivel de conocimiento y aplicación de la Medicina Natural y Tradicional en adultos mayores
Authors: Díaz-Rodríguez Yusnier Lázaro , Torrecilla-Venegas Rolando , Peña-Crespo Marlon , Molina-López Javier Agustín , Quintana-López Luis Amado 
Published: May 2021

Introducción: los adultos mayores son considerados de riesgo por las disímiles vulnerabilidades que acompañan a la senescencia, de ahí que se recomienda la aplicación de procedimientos de la Medicina Natural y Tradicional para garantizar consigo una mayor calidad de vida.
Objetivo: caracterizar el nivel de conocimiento y aplicación de la Medicina Natural y Tradicional en adultos mayores.
Material y métodos: se realizó un estudio observacional, descriptivo de corte transversal en un grupo de adultos mayores pertenecientes al Policlínico Docente “Manuel González Díaz”, Bahía Honda, Artemisa; en el periodo de septiembre a octubre de 2020. El universo estuvo conformado por 150 adultos mayores, trabajándose con la totalidad. Se recogió la información a partir de una encuesta. Se utilizó estadística descriptiva.
Resultados: predominó el grupo de edades de 60 a 69 años (35,33 %) y el sexo femenino (56,67 %). El 95,33 % (N=143) refirieron conocimientos sobre la Medicina Natural y Tradicional, consideraron los procedimientos terapéuticos como útiles y efectivos y afirmaron su aplicación. De ellos el 100 % refirió conocer y aplicar la fitoterapia como procedimiento terapéutico. Las recomendaciones de familiares y amigos fueron el medio de adquisición de los conocimientos sobre la Medicina Natural y Tradicional más representativo (76,92 %).
Conclusiones: el nivel de conocimiento y aplicación de la Medicina Natural y Tradicional en los adultos mayores estudiados fue elevado. Es necesario aumentar en variedad la aplicación de procedimientos terapéuticos de la Medicina Natural y Tradicional y fomentar el papel de los profesionales de la salud como difusores de su utilidad.
A MODIFYING GO AND DOPING IT IN WATERBORNE ACRYLIC COATINGS TO ENHANCE THEIR MECHANICAL PERFORMANCE AND CORROSION PROTECTION
Authors: Wang Xiao , Xie Yixiao , Cong Weiwei , Li Zhaolei , Xu Zexiao , Yan Hui , Gui Taijiang , Li Weili 
Published: June 2021

With the development of science and technology and the ever-increasing focus of the environmental protection, waterborne acrylic resin based coating has been commonly used in a wide range of applications due to its high flexibility and good UV resistance. Continuous attempts have been extensively carried out to improve its corrosion resistance and mechanical properties through doping of different nanomaterials. In this study, Functionalized Graphene Oxide (FGO) nanosheets covalently bonded to hydroxylated acrylic resin was introduced into the Hydroxyacrylic Acid Dispersion (HAD) matrix to enhance the performance. To study the effect of grafted hydroxylated acrylic resin on morphology and properties of GO nanosheets, the GO and FGO nanosheets have been systematically characterized with various testing methods, such as FTIR, field emission-scanning electron microscopy (FE-SEM), transmission electron microscope (TEM), Raman spectroscopy, X-ray diffraction (XRD) analysis, UV–vis analysis, and thermogravimetric analysis (TGA). The morphology, physical–mechanical, and anti-corrosion properties of the HAD coatings doped with GO and FGO nanosheets have been compared. The results confirmed that FGO’s dispersion behavior in the HAD matrix has been improved after modifification with the hydroxylated acrylic resin, and the interfacial bonds between the HAD-FGO nanosheets have been significantly enhanced.
Relationship between RS time and the severity of chronic obstructive pulmonary disease
Authors: YILDIZ İbrahim , ÖZMEN YILDIZ Pınar , SAZLIDERE Hüsamettin , GÜREVİN Mehmet Sait , RENCÜZOĞULLARI İbrahim , KARABAĞ Yavuz , BURAK Cengiz , ÖZMEN Çağlar 
Published: May 2021

Purpose: The aim of our study was to determine whether the RS time measured on an electrocardiogram is associated with the severity of chronic obstructive pulmonary disease (COPD).
Materials and Methods: The study population was made up of 100 COPD patients with a mean age of 63 ± 10 years (86% were males). These patients were divided into the mild and moderate COPD (GOLD 1–2) group (n = 45) and the severe and very severe COPD (GOLD 3–4) group (n = 55) according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages. These groups were compared with each other.
Results: Heart rate, P wave axis, QRS axis, RS time, and incidence of right bundle branch block were significantly higher in patients with severe and very severe COPD. In the multivariable analysis, heart rate, P wave axis, and RS time (odds ratio = 1.081) were the independent predictors of severe and very severe COPD. The receiver operating characteristic curve analysis showed that the best RS time cutoff value for the prediction of severe and very severe COPD was 60 ms, with a sensitivity of 69.1% and a specificity of 66.7%.
Conclusion: RS time simply measured on an electrocardiogram may be a useful screening test for the quick estimation of patients with severe and very severe COPD.
PENGARUH CORPORATE REPUTATION, BRAND SATISFACTION DAN BRAND ATTITUDE TERHADAP CUSTOMER LOYALTY PADA INDUSTRI PENERBANGAN DI INDONESIA [THE EFFECT OF COMPANY REPUTATION, BRAND SATISFACTION AND BRAND ATTITUDES TOWARDS CUSTOMER LOYALTY IN THE FLIGHT INDUSTRY IN INDONESIA]
Authors: Keni Keni , Dharmawan Purnama , Wilson Nicholas 
Published: May 2021

<p><em>This research was conducted in order to uncover the effect of Reputasi Perusahaan, Kepuasan Merek and Sikap Merek, both direct and indirectly toward Loyalitas Konsumen in the Indonesian airlines industry. This research implemented survey method in which a total of 300 questionnaires were distributed to the respondents who participated in this research. After a thorough analysis, all of the data had been deemed valid and usable to be further processed in this research. All of the data were then further analyzed by using Partial Least Suares-Structural Equation Modeling (PLS-SEM) by using SmartPLS 3.2.8 modeling software. Based on the results of the data analysis, authors would like to conclude that both Reputasi Perusahaan and Kepuasan Merek had a positive impact on Loyalitas Konsumen, both directly and indirectly through Sikap Merek, in the Indonesian airlines industry.</em></p><p><strong>Abstrak dalam Bahasa Indonesia</strong> Penelitian ini dilakukan guna mengetahui bagaimana pengaruh reputasi perusahaan, kepuasan merek dan sikap merek terhadap loyalitas pelanggan pada industri penerbangan di Indonesia. Penelitian ini mengimplementasikan metode survei, dimana kuesioner dipilih dan digunakan sebagai instrumen untuk mengumpulkan data dari responden yang berpartisipasi didalam penelitian ini. Adapun kuesioner akan disebarkan kepada 300 responden yang berpartisipasi pada penelitian ini, dimana berdasarkan hasil analisis awal terhadap data penelitian, seluruh data dinyatakan valid dan dapat digunakan didalam penelitian ini. Setelah seluruh data berhasil dikumpulkan, maka data selanjutnya diolah dengan menggunakan metode Partial Least Squares-Structural Equation Modeling (PLS-SEM) dengan menggunakan perangkat lunak SmartPLS 3.2.8. Berdasarkan hasil analisis data, peneliti menyimpulkan bahwa reputasi perusahaan dan kepuasan merek berpengaruh positif terhadap loyalitas pelanggan, baik secara langsung maupun tidak langsung melalui sikap merek, pada industri penerbangan di Indonesia.</p><p> </p>
Correction to the article “Translation, Adaptation and Validation of the European Portuguese Version of the NMS-Quest for Parkinson’s Disease”, Published on Acta Med Port 2021 Jan;34(1):6-11.
Authors: Silva Alexandra , Pedro Tiago , Moreira Fradique 
Published: June 2021

On the title of Appendix 1, where it reads:“Appendix 1: Validated European Portuguese version of the “Non-Motor Symptoms Questionnaire”It should read:“Appendix 1: Validated European Portuguese version of the “Non-Motor Symptoms Questionnaire. Copyright© [2021]International Parkinson and Movement Disorder Society (MDS). All rights reserved. Provisional translation used with permission of MDS.”Article published with errors: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13160
Provimento aos cargos de diretores: efeitos em escolas públicas fluminenses
Authors: Cunha Sergio Gonçalves da 
Published: May 2021

Resumo Foi realizado um quase-experimento avaliando impactos das mudanças nas formas de provimento ao cargo de gestores de escolas fluminenses no trabalho docente e no desempenho discente, utilizando dados da Prova Brasil (2007 a 2015), Imputações Múltiplas para lidar com perdas amostrais, Análise Fatorial para criação de Índices de liderança dos diretores e o estimador Diferenças em Diferenças para captação de efeitos nas variáveis de interesse. Os resultados sugerem que não houve mudanças estatisticamente significativas no desempenho dos alunos e na percepção de liderança entre os docentes nas unidades investigadas em Macaé ao adotarem prova associada à eleição. Nas demais escolas tratadas, mudanças ocorreram no desempenho dos alunos em Língua Portuguesa e Matemática após a adoção das eleições. Palavras-chave: gestão escolar; liderança; desempenho.
Avaliação da leitura de crianças em processo de alfabetização
Authors: Silva Olívia Coelho da , Ribeiro Ana Paula De Medeiros 
Published: May 2021

O artigo apresenta uma investigação documental com o objetivo de identificar e analisar os instrumentos de avaliação em leitura propostos pela Secretaria Municipal de Fortaleza e pela escola aplicados aos alunos do 2º ano. Anualmente, as crianças são avaliadas pelo Sistema Permanente de Avaliação da Educação Básica do Ceará. Essa avaliação externa influencia consideravelmente as ações pedagógicas da escola. As conclusões são: o instrumental de avaliação disponibilizado pela Secretaria Municipal de Educação apresenta fragilidades quanto ao adequado diagnóstico sobre a compreensão leitora dos alunos; observou-se que o teste denominado simulado analisado foram identificados alguns deslizes técnicos na elaboração dos comandos e nas alternativas de respostas em itens que compuseram o teste.
Employing NADH Dehydrogenase Subunit 1 in the Determination of Echinococcus granulosus Strain in Sheep, Cattle and Human in Thi-Qar Province, Iraq
Authors: AL-Asadi Sarmad Awad Mozan , Hansh Wesam Jasim , Awad Abdul-Hussien Habash 
Published: June 2021

Echinococcosis is a zoonotic disease caused by the larval stage of the tapeworm Echinococcus granulosus. This disease is an important public health and a significant economic issue in Iraq, where the lungs and livers are the popular places of infection. The aim of the current study focused on using the molecular techniques in the detection of an E. granulosus strain that causes cystic echinococcosis to human, sheep and cattle in Thi-Qar province, Iraq. In the current study, thirty isolates of E. granulosus were collected from 10 human hydatid cysts through surgery done at Al-Hussein Imam Teaching Hospital in Thi-Qar province and 10 sheep with 10 cattle hydatid cysts were obtained from the slaughterhouse in Thi-Qar province, Southern of Iraq to identify strains of E. granulosus which infect human and other intermediate hosts (sheep and cattle). The molecular study was carried out on the isolates and a specific primer set for the mitochondrial dehydrogenase NADH subunit 1 (NAD1) gene was used. This primer set was amplified 400 bp of the NAD1 gene in all selected isolates. The PCR products for the twelve selected isolates of E. granulosus (4 isolates per intermediate host) were sequenced and the results for these twelve isolates showed that all sequenced isolates, except one isolate Eg_5, belonged to the sheep strain G1 and a slight genetic diversity was observed with the reference sequences of the strain G1. The exception was in the isolate Eg_5 isolated from a cattle liver, which was similar to the buffalo strain G3. This study concludes that the common E. granulosus strain in Thi-Qar province is G1.
APPLICATION OF INQUIRY BASED LEARNING MODEL USING STEM APPROACH TO REDUCE STUDENTS' INTRINSIC COGNITIVE LOAD
Authors: Sundari Rita , Ahmed Omnia Salah , Abdurrahman Abdurrahman , Herlina Kartini 
Published: June 2021

This study is an experimental research using a quasi-experimental design with the type of non-equivalent control group pretest-posttest. This research aims to reduce Intrinsic Cognitive Load (ICL) through Inquiry Based Learning (IBL) model based STEM approach. This research was conducted at SMA Negeri 1 Seputih Banyak with the research subjects of class X IPA 1 students and X IPA 4. An data Intrinsic Cognitive Load obtained from essay the pretest-posttest (Task Complexity worksheet). Cognitive load test data analysis was performed using the data normality test, N-gain test and hypothesis test using the Paired Sample T-Test. The experimental class implements the Inquiry Based Learning model based audio and visual using STEM approach while the control class is nonaudio and visual. The results showed by the average value of N-Gain Intrinsic Cognitive Load (ICL) in the experimental class was 0.63 with the moderate category and the control class was 0.18 with the low category. Based on data analysis, can be concluded that there is a positive influence in the form of a decrease in the cognitive load Intrinsic Cognitive Load (ICL) in the experimental class using the Inquiry Based Learning model plus an audio and visual based STEM approach.
DEVELOPING ELECTRONIC STUDENT WORKSHEET (E-WORKSHEET) BASED PROJECT USING FLIPHTML5 TO STIMULATE SCIENCE PROCESS SKILLS DURING THE COVID-19 PANDEMIC
Authors: Febriansyah Ferdi , Herlina Kartini , Nyeneng I Dewa Putu , Abdurrahman Abdurrahman 
Published: June 2021

This research aims to develop worthy (in terms of validity and practicality) Electronic Student Worksheets (E-Worksheet) based project using FlipHTML5 in light interference topic. E-Worksheet developed to stimulate student’s science process skills. This research used design and development research (DDR) which consisted of 4 stages, namely analysis, design, development, and evaluation. The results of the product validity were assessed by experts consisting of two high school physics teachers and a lecturer from the physics education department of the University of Lampung who got an average score of 3.56 with the very valid category. The E-Worksheet practicality in terms of the legibility, the student views that was completed by 9 students, and the teacher views that was completed by 5 high school physics teachers got an average percentage of 90% with the very practical category. These results showed that E-Worksheet were valid and very practical to stimulate student’s science process skills. Based on teacher views, the E-Worksheet is very possible to be implemented in online and face-to-face learning especially in the covid-19 pandemic era. The E-Worksheet can be used as multimedia to support online learning.
A ranking-based differential evolution algorithm for hybrid flow shop sustainable scheduling
Authors: Wang Liming , Kong Lin , Li Fangyi , Lv Xiaoteng 
Published: June 2021

Abstract
With the increasing of environmental pressure, the sustainable production for hybrid flow shops (HFS) has attracted more attention due to its broad industrial applications. In implementing the sustainable production of HFS, the selection of parallel machines for various jobs is a vital step. In light of this, a multi-objective mathematical model for minimization of makespan and energy consumption of HFSP was formulated. The sustainability of parallel machines were evaluated and ranked according to fuzzy TOPSIS method. To solve the multi-objective model of HFSP, an improved differential evolution algorithm was presented to assign the job with the ranked parallel machines, which can narrow the search scope and accelerate the convergence speed. Finally, a case study was presented to evaluate the effectiveness of the proposed ranking-based algorithm and to prove the feasibility of the model. The results showed that the proposed improved algorithm outperforms NSGA-II and PSO in searching for non-dominated solutions, which can effectively solve the sustainable production of HFSP.