bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal and Skeletal Anomalies in a Cohort of Individuals With Clinically Presumed Hereditary Nephropathy Analyzed by Molecular Genetic Testing
Authors: Stippel Michaela , Riedhammer Korbinian M. , Lange-Sperandio Bärbel , Geßner Michaela , Braunisch Matthias C. , Günthner Roman , Bald Martin , Schmidts Miriam , Strotmann Peter , Tasic Velibor , Schmaderer Christoph , Renders Lutz , Heemann Uwe , Hoefele Julia 
Published: May 2021

Background: Chronic kidney disease (CKD) in childhood and adolescence occurs with a median incidence of 9 per million of the age-related population. Over 70% of CKD cases under the age of 25 years can be attributed to a hereditary kidney disease. Among these are hereditary podocytopathies, ciliopathies and (monogenic) congenital anomalies of the kidney and urinary tract (CAKUT). These disease entities can present with a vast variety of extrarenal manifestations. So far, skeletal anomalies (SA) have been infrequently described as extrarenal manifestation in these entities. The aim of this study was to retrospectively investigate a cohort of individuals with hereditary podocytopathies, ciliopathies or CAKUT, in which molecular genetic testing had been performed, for the extrarenal manifestation of SA.Material and Methods: A cohort of 65 unrelated individuals with a clinically presumed hereditary podocytopathy (focal segmental glomerulosclerosis, steroid resistant nephrotic syndrome), ciliopathy (nephronophthisis, Bardet-Biedl syndrome, autosomal recessive/dominant polycystic kidney disease), or CAKUT was screened for SA. Data was acquired using a standardized questionnaire and medical reports. 57/65 (88%) of the index cases were analyzed using exome sequencing (ES).Results: 8/65 (12%) index individuals presented with a hereditary podocytopathy, ciliopathy, or CAKUT and an additional skeletal phenotype. In 5/8 families (63%), pathogenic variants in known disease-associated genes (1x BBS1, 1x MAFB, 2x PBX1, 1x SIX2) could be identified.Conclusions: This study highlights the genetic heterogeneity and clinical variability of hereditary nephropathies in respect of skeletal anomalies as extrarenal manifestation.
Homocysteine and Folic Acid: Risk Factors for Alzheimer's Disease—An Updated Meta-Analysis
Authors: Wang Qianwen , Zhao Jingjing , Chang Hongtao , Liu Xu , Zhu Ruixia 
Published: May 2021

Background:Recent studies have reported that homocysteine (Hcy) may play a vital role in the pathogenesis of vascular dementia (VaD) and Alzheimer's disease (AD). Our study explored the relationship between the plasma Hcy and folate levels and the risk of dementia.Methods:We searched Embase, PubMed, and Web of Science for published literature, including case-control studies and prospective cohort studies, and performed a systematic analysis.Results:The results of our meta-analysis, consisting of case-control studies, showed higher levels of Hcy and lower levels of folate in dementia, AD, and VaD patients than those in non-demented controls (for dementia: SMD = 0.812, 95% CI [0.689, 0.936],p= 0.000 for Hcy; SMD = −0.677, 95% CI [−0.828, −0.525],p= 0.000 for folate). AD patients showed significantly lower plasma Hcy levels compared to VaD patients (SMD = −0.278, 95% CI [−0.466, −0.09],p= 0.000). Subgroup analysis revealed that ethnicity, average age, and dementia type had no significant effect on this association. Furthermore, from the analysis of prospective cohort studies, we identified that elevated plasma Hcy levels were associated with an increased risk of dementia, AD, and VaD (RRdementia= 1.22, 95% CI [1.08, 1.36]; RRAD= 1.07, 95% CI [1.04, 1.11]; RRVaD= 1.13, 95% CI [1.04, 1.23]). In addition, every 5 μmol/L increase in the plasma Hcy level was associated with a 9% increased risk of dementia and a 12% increased risk of AD.Conclusion:Hcy and folic acid are potential predictors of the occurrence and development of AD. A better understanding of their function in dementia could provide evidence for clinicians to rationalize clinical intervention strategies.
A Nomogram for Predicting Risk of Thromboembolism in Gastric Cancer Patients Receiving Chemotherapy
Authors: Yuan Hai-Liang , Zhang Xiang , Li Yan , Guan Qing , Chu Wei-Wei , Yu Hai-Ping , Liu Lian , Zheng Yun-Quan , Lu Jing-Jing 
Published: May 2021

Purpose: The aims of this study were to develop and validate a novel nomogram to predict thromboembolism (TE) in gastric cancer (GC) patients receiving chemotherapy and to test its predictive ability.Methods: This retrospective study included 544 GC patients who received chemotherapy as the initial treatment at two medical centers. Among the 544 GC patients who received chemotherapy, 275 and 137 patients in the First Affiliated Hospital of Nanchang University from January 2014 to March 2019 were enrolled in the training cohort and the validation cohort, respectively. A total of 132 patients in the Beilun branch of the First Affiliated Hospital of Zhejiang University from January 2015 to August 2019 were enrolled in external validation cohorts. The nomogram was based on parameters determined by univariate and multivariate logistic analyses. The prediction performance of the nomogram was measured by the area under the receiver operating characteristic curve (AUROC), the calibration curve, and decision curve analysis (DCA). The applicability of the nomogram was internally and independently validated.Results: The predictors included the Eastern Cooperative Oncology Group Performance Status (ECOG), presence of an active cancer (AC), central venous catheter (CVC), and D-dimer levels. These risk factors are shown on the nomogram and verified. The nomogram demonstrated good discrimination and fine calibration with an AUROC of 0.875 (0.832 in internal validation and 0.807 in independent validation). The DCA revealed that the nomogram had a high clinical application value.Conclusions: We propose the nomogram for predicting TE in patients with GC receiving chemotherapy, which can help in making timely personalized clinical decisions for different risk populations.
Robotic distal subtotal gastrectomy with D2 lymphadenectomy for advanced gastric cancer: a case report and technical description
Authors: Francesco Giovanardi  
Published: May 2021

Robotic systems have revolutionized the way we perform minimally invasive surgery and has facilitated the evolution of traditional laparoscopic gastric surgery. Surgeons have several advantages that can overcome some of the well-known limits of laparoscopy: three-dimensional vision, articulated instruments, the absence of tremors. These can give greater dexterity and precision in dissection and suturing movements that are key elements when performing complex and gentle reconstruction to restore digestive continuity. The present case shows the technical details and tips and tricks of a robotic surgical approach for a subtotal gastrectomy.
Prácticas discursivas del saber pedagógico y la gestión curricular
Authors: Quiñones Idárraga Juan Esteban 
Published: May 2021

Al abordar la pedagogía como saber fundante, se genera un espacio de configuración para la comprensión de cómo la pedagogía y el currículo habitan un mismo discurso en la voz del maestro desde las prácticas pedagógicas. Es prudente advertir que en el presente documento se hará una línea de relato que posibilita comprender los lugares de enunciación y puntos de partida para la comprensión del saber pedagógico y la gestión curricular, para luego pasar a las interacciones que se gestan en el aula desde los procesos de aprendizaje, para llegar finalmente a cómo la deliberación de conocimiento se convierte en este espacio de encuentro del saber pedagógico y la gestión curricular.
Hay en el fondo, una intención de plasmar la necesidad de reconocer la narrativa del maestro, su historia, la historicidad de la pedagogía y la concepción del aprendizaje como palabras que habitan el lenguaje de la educación, y que se materializan desde la interacción del saber pedagógico y la gestión curricular.
BUILDING AN INTELLIGENT TRANSPORT SYSTEM ON THE CRIMEAN PENINSULA AS A METHOD TO INCREASE THE EXCHANGE RATE OF REGIONAL LOGISTICS PROCESSES
Authors: Kripak Marina , Kiyashko Larisa 
Published: May 2021

The well-known approaches to the process of building an intelligent transport sys tem are considered. The problems of digitalization of the economy are posed. The theory of economic
zoning is proposed as a basis for the design of an intelligent transport system on the Crimean penin sula. To solve the problem, the methods of collecting information, analyzing documentation, generaliz ing, grouping, Voronoi diagram were used.
EVALUATION OF CORRESNDENCE MATRICES TAKING INTO ACCOUNT TRANSPORT FLOW RESTRICTIONS
Authors: Lebedeva Ol'ga 
Published: May 2021

Travel demand forecasting models are a key analysis tool used in transport network
planning and infrastructure development. Relevant research within this topic is aimed at reducing the
time and minimizing costs associated with the development of a forecasting model for travel demand,
which is used for forecasting and planning. The study evaluates the possibility of recovering an exact
correspondence matrix based on an overloaded network, which considers the conditions relative to
the base / initial matrix, traffic flow and their impact on the quality of the generated matrix
ON THE QUESTION OF ORGANIZATION SUSTAINABLE RAILWAY TRAFFIC
Authors: Upyr' Roman , Domozhirova Alena 
Published: May 2021

An approach to determining the stable movement of trains in conditions of uneven
carriage flow is considered. The approach is based on the idea of train movement as a cyclical pro cess that allows you to formalize the classical graphical representation of trains on the graph, and on
the transition from a static model to a controlled dynamic system
FEATURES OF CALCULATION OF VIBRATIONS OF A PINCHED ROUND PLATE
Authors: Cherepanov Anatoliy 
Published: May 2021

A method for calculating the vibrations of a circular steel plate, clamped around the
circumference and loaded with a short-term load, with the determination of the frequency of the fun damental tone (the lowest type of vibration), is considered. For practical calculations, the influence of
the mass of the plate itself, as well as the mass of air or liquid, on the frequency of natural oscillations
is taken into account.
FEATURES OF CALCULATING THE DEFLECTION OF ROUND PLATES
Authors: Cherepanov Anatoliy 
Published: May 2021

A method for calculating the deflection of a round flat steel plate bearing an ax isymmetric load is considered. For practical calculations, dimensionless coefficients of deflection in the
center of the plate, deflection at a certain distance from the center of the plate, the stress coefficient
and the accompanying function, which depends on the deflection of the plate and the pressure force
on it, are used.
PROBLEMS AND PROSPECTS FOR THE DEVELOPMENT OF THE BAIKALO-AMUR AND TRANS-SIBERIAN RAILWAYS WHEN TRANSPORTING ENERGY RESOURCES IN MODERN CONDITIONS
Authors: Golovschikov Vladimir 
Published: May 2021

Plans for the expansion of the BAM and Transsib were considered in the framework
of the development of the Eastern range, aimed at a significant increase in the export supplies of Rus sian natural resources to Northeast Asia. The increase in the throughput capacity of the BAM and
Transsib also implies an increase in transcontinental container traffic from the countries of Northeast
Asia to Europe. The current situation in the BAM and Transsib zones, as well as the risks and threats
to the plans for the development of these railways, are considered.
PREDICTIVE REGULATORS FOR GAS TURBINE PLANTS
Authors: Nguen Van , Chan Zyuy 
Published: May 2021

The efficient operation of gas turbine units (GTU) in isolated power supply systems
with variable load is impossible without the presence of coordinatedly tuned automatic regulators, the
adjustment of which requires calculations using complex algorithms. The use of predictive controllers
makes it possible to significantly simplify these calculations and quickly put the gas turbine into
operation
BARRIER CHARACTERISTICS OF SANDS IN THE PROTECTION OF ENVIRONMENTAL WITH POLLUTION PETROLIUM PRODUCTS
Authors: Nguen Chung , Nguen Thi , Mai Thi 
Published: May 2021

The efficiency of absorption of gasoline and motor lubricating oil through sand layers
is investigated. The influence of different heights of sand layers on the degree of retention of petrole um products is considered. The results obtained, which reached more than 80% at a layer height of 8
cm, allow assessing the barrier role of sand in preventing oil pollution of soils and reservoirs.
HYGIENIC ASSESSMENT OF WORKING CONDITIONS IN THE WORKPLACE A SAWYER IN A WOODWORKING SHOP
Authors: Pankov Vladimir , Lufarenko Yana 
Published: May 2021

The assessment of working conditions at the workplace of the sawyer in the wood working shop was carried out. The leading factors of the production environment are shown, their hy gienic assessment is given according to the degree of harmfulness and danger, the severity of the
labor process, and the final class of working conditions is determined
MOTIVATION AS A MAJOR FACTOR IN THE ACADEMIC ACTIVITY OF A MODERN STUDENT
Authors: Kompaniec Tat'yana 
Published: May 2021

The article discusses the concepts of «motivation» and «motive» and their im portant role in the process of students' education in a higher educational institution at the present
stage of development of society. Functioning of external and internal motives in the educational moti vation, their differences and direct dependence as a factor of formation of successful training and in
further formation of a specialist.
HALOGENATION OF N-ARYLSULFONYL-3-POLYCHLOROMETHYL-2- AZABICYCLO[2.2.1]HEPT-5-ENES
Authors: Katerinich Maksim , Chernysheva Gul'nur 
Published: May 2021

An approach to the preparation of new polyhalogenated N-sulfonylsubstituted
azanorbornane derivatives, which are of interest as valuable reagents and promising biologically ac tive substances, has been demonstrated
ANALYSIS OF A SAMPLE OF DIHYDROQUERCETIN FOR CONTENT IMPURITIES
Authors: Kondrat'eva Larisa , Sverdlova Ol'ga , Dobrynina Nadezhda 
Published: May 2021

A chromatographic analysis of a sample of dihydroquercetin obtained using mem brane purification was carried out for the content of impurities - quercetin, aroma-dendrin, naringenin,
and luteolin. According to the research data, the purity of the obtained dihydro-vercetin corresponds to
the standard sample.
ELECTIONS OF VILLAGE COUNCILS IN THE SECOND HALF OF THE 1920S. IN EASTERN SIBERIA (ON THE EXAMPLE OF THE IRKUTSK DISTRICT)
Authors: Cubikova Lyubov' 
Published: May 2021

The article is devoted to the electoral campaigns for the re-election of rural councils in
the second half of the 1920s. The paper analyzes the reasons for the turnout growth of the population in
the elections to village councils, their motives.
THE PROSPECTIVE USE OF METHYLDIETHANOLAMINE IN THE TREATING OF PROCESS GASES FOR HYDRIGEN SULFIDE REMOVAL ON THE DIESEL FUEL HYDROCLEANING UNIT JSC «ANHK»
Authors: Novichihin Dmitriy , Kuzora Igor' 
Published: May 2021

It was considered the possibility of using methyldiethanolamine solution instead of
monoethanolamine solution for hydrogen sulfide removal from process gases in diesel fuel
hydrocleaning unit JSC «ANHK». It is demonstrated some advantages and disadvantages
methyldiethanolamine-based circulating absorbent in comparison of monoethanolamine-based absor bent.
ORGANIZATION OF PRODUCTION OF HYDROCARBON BASE FOR DRILLING FLUIDS IN JSC «ANGARSK PETROCHEMICAL COMPANY» AND DEVELOP MENT OF MEASURES TO INCREASE THE VOLUME OF ITS PRODUC
Authors: Stadnik Aleksandr , Kuzora Igor' 
Published: May 2021

JSC «ANHK» has developed and introduced into production a technology for pro duction the base for drilling fluids based on high conversion oil refining. The development of the tech nology included: analysis of the existing processes and the quality of the company's raw materials;
development of engineering models for producing the base for drilling fluids; laboratory tests; imple mentation of pilot industrial runs at installations; calculation of the economic effect; production launch
and development of normative documents. Also described are measures to increase the volume of
production of a new product
HYDRAULIC RESISTANCE OF A COMBINED SINGLE-FLOW STRAINER PLATE WITH A MOVABLE BALL PACK
Authors: Ul'yanov Boris , Fereferov Mihail , Hortov Aleksandr 
Published: May 2021

The report presents the method of experiments and the results of the study of the
hydrodynamics of the gas-liquid system on a strainer one-threaded plate with a movable ball pack
with different density of ball elements.
USE OF PYRAZOLE-CONTAINING ISOTHIURONIUM SALTS AS GLOSS FORMING ADDITIVES IN ELECTROCHEMICAL NICKEL PLATING TECHNOLOGY
Authors: Shaferova Marina , Sosnovskaya Nina , Kobelevskaya Valentina , Korchevin Nikolay 
Published: May 2021

The introduction of available pyrazole-containing isothiuronium salts as additives to
a standard nickel-plating sulfate electrolyte for the electrochemical production of shiny nickel coatings
is considered
PREVALENCE OF CROSSBITE IN SCHOOL CHILDREN OF SUNDAR INDUSTRIAL STATE AND RAIWIND, LAHORE: AN EPIDEMIOLOGICAL STUDY
Authors: Rabia Tabassum  , Nazish Amjad  , Faiza Malik  , Munazza Saleem  
Published: May 2021

BACKGROUND & OBJECTIVE: Crossbite is a commonly occurring malocclusion. It may be anterior or posterior, and it may occur either unilaterally or bilaterally. This study determined the prevalence of crossbite in children of different schools of Sundar industrial state and Raiwind.
METHODOLOGY: Nine hundred (428 male and 472 female) children of various schools of Raiwind and Sundar Industrial State, Lahore, were examined. Information regarding age, sex, and crossbite were noted. The recorded data were analyzed by using SPSS version 20. Frequency distribution was used for the descriptive analysis. Statistical level of significance using student’s t-test was p< 0.05.
RESULTS: Out of 900 children, 117(13%) were noted to have at least one tooth in crossbite, which was more frequent in permanent (13.2%) than in mixed dentition (12.3%). The prevalence of crossbite was slightly greater in female subjects (16.1%) than in male subjects (9.1%). Crossbite was seen more frequently in the posterior (6.3%) than the anterior region (5.9%). Combined anterior and posterior crossbite was found in 7(0.8%) children. Unilateral crossbite on the left side was found to be more frequent (6.6%) than on the right side (4.6%), and the bilateral crossbite was found to be in 1.9% of children. Buccal crossbite was more prevalent (6.8%) than lingual crossbite (5.8%). Combined lingual and buccal crossbite was found to be in 0.4% of children.
CONCLUSION: Crossbite is a frequently occurring malocclusion in school children of Sundar industrial state and Raiwind, Lahore. Posterior crossbite is more prevalent than anterior crossbite.
Dissecting the Quadruple Binary Hyad vA 351 Masses for Three M Dwarfs and a White Dwarf*
Authors: Benedict G. Fritz , Franz Otto G. , Horch Elliott P. , Prato L. , Torres Guillermo , McArthur Barbara E. , Wasserman Lawrence H. , Latham David W. , Stefanik Robert P. , Latham Christian , Skiff Brian A. 
Published: May 2021

Abstract
We extend results first announced by Franz et al., that identified vA 351 = H346 in the Hyades as a multiple star system containing a white dwarf. With Hubble Space Telescope Fine Guidance Sensor fringe tracking and scanning, and more recent speckle observations, all spanning 20.7 years, we establish a parallax, relative orbit, and mass fraction for two components, with a period,

and total mass 2.1

. With ground-based radial velocities from the McDonald Observatory Otto Struve 2.1 m Telescope Sandiford Spectrograph, and Center for Astrophysics Digital Speedometers, spanning 37 years, we find that component B consists of BC, two M dwarf stars orbiting with a very short period (

days), having a mass ratio

/

= 0.95. We confirm that the total mass of the system can only be reconciled with the distance and component photometry by including a fainter, higher-mass component. The quadruple system consists of three M dwarfs (A, B, C) and one white dwarf (D). We determine individual M dwarf masses

= 0.53 ± 0.10

,

= 0.43 ± 0.04

, and

= 0.41 ± 0.04

. The white dwarf mass, 0.54 ± 0.04

, comes from cooling models, an assumed Hyades age of 670 Myr, and consistency with all previous and derived astrometric, photometric, and radial velocity results. Velocities from Hα and He i emission lines confirm the BC period derived from absorption lines, with similar (He i) and higher (Hα) velocity amplitudes. We ascribe the larger Hα amplitude to emission from a region each component shadows from the other, depending on the line of sight.
Revealing the Local Cosmic Web from Galaxies by Deep Learning
Authors: Hong 홍 Sungwook E. 성욱 , Jeong Donghui , Seong Hwang Ho , Kim Juhan 
Published: May 2021

Abstract
A total of 80% of the matter in the universe is in the form of dark matter that composes the skeleton of the large-scale structure called the cosmic web. As the cosmic web dictates the motion of all matter in galaxies and intergalactic media through gravity, knowing the distribution of dark matter is essential for studying the large-scale structure. However, the cosmic web’s detailed structure is unknown because it is dominated by dark matter and warm−hot intergalactic media, both of which are hard to trace. Here we show that we can reconstruct the cosmic web from the galaxy distribution using the convolutional-neural-network-based deep-learning algorithm. We find the mapping between the position and velocity of galaxies and the cosmic web using the results of the state-of-the-art cosmological galaxy simulations of Illustris-TNG. We confirm the mapping by applying it to the EAGLE simulation. Finally, using the local galaxy sample from Cosmicflows-3, we find the dark matter map in the local universe. We anticipate that the local dark matter map will illuminate the studies of the nature of dark matter and the formation and evolution of the Local Group. High-resolution simulations and precise distance measurements to local galaxies will improve the accuracy of the dark matter map.
A Single Pulse Study of a Millisecond Pulsar PSR J0621+1002
Authors: Wang S. Q. , Wang J. B. , Wang N. , Feng Y. , Zhang S. B. , Lee K. J. , Li D. , Lu J. G. , Xie J. T. , Zhou D. J. , Zhang L. 
Published: May 2021

Abstract
We present radio observation of a millisecond pulsar PSR J0621+1002 using the Five-hundred-meter Aperture Spherical radio Telescope. The pulsar shows periodic pulse intensity modulations for both the first and the third pulse components. The fluctuation spectrum of the first pulse component has one peak of 3.0 ± 0.1 pulse periods, while that of the third pulse component has two diffused peaks of 3.0 ± 0.1 and 200 ± 1 pulse periods. The single pulse timing analysis is carried out for this pulsar and the single pulses can be divided into two classes based on the post-fit timing residuals. We examined the achievable timing precision using only the pulses in one class or bright pulses. However, the timing precision improvement is not achievable.