bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensory analysis affective test and microbiological characteristics of the development formulation drink moringa date palm water extract
Authors: Yuliyana Triagung , Rimbawan Rimbawan , Damayanthi Evy , Palupi Eny , Iwansyah Ade Chandra 
Published: January 2025

Link of Video Abstract: https://youtu.be/qiWALY9_ujU

Introduction: There is growing interest in the non-nutritional bioactive compounds present in food and beverages as possible "life nutrients" for preventing noncommunicable diseases. The dates moringa juice drink is a functional beverage that represents a rich source of bioactive compounds including carotenoids, phenolic acids, flavonoids, coumarins, alkaloids, polyacetylenes, saponins, and terpenoids. This study aimed to investigate the impact of incorporating various concentrations of moringa extract on the sensory quality and preference rating of date moringa juice.
Methods: The sample from the sensory test with the highest score were subsequently the color analysis was conducted using a chromameter, to perform the investigation, labels, iceboxes, mineral water, and questionnaires were used. The formulation procedure involved combining date palm juice (30%, 35%, 40%) in appropriate proportions with moringa extract.
Results: The statistical test's results for hedonic ratings revealed significant differences in dates moringa juice drink taste, aroma, and viscosity. The test also revealed that the dates moringa juice drink, Formula 1 with 30% added date palm juice, was the most favored in terms of taste of 6.38, aroma of 5.84, color of 6.23. The microbiological attributes total lactic acid bacteria (LAB) were 1.0 x 103 colonies/g, negativity for Salmonella, and an E. coli count 0 APM/g with a pH of 6.42 according to formula 1.
Conclusion: The most favored for water extracts of moringa and date palm treatment was the addition of 30% juice, which received a high preference rating from 35 panelists. F1 formula’s a higher mean score for six sensory attributes color, viscosity, aroma, taste, mouthfeel, and aftertaste. F1 formula’s a lower mean score for the microbiological attributes.
Unrevealing the role of lacritin in eye disease: An updated systematic review
Authors: Eka Hasnah , Ichsan Andi Muhammad , Massi Muh. Nasrum , Muhiddin Habibah Setyawati , SU Suhardjo , Umar Batari Todja , Miskad Upik , Zairuddin Andi Alfian 
Published: January 2025

Link of Video Abstract: https://youtu.be/L9MLcss_SBI

Introduction: Lacritin is a potential human tear glycoprotein for treating some diseases involving eye such as bacterial corneal ulcers. However, the specific role of lacritin in improving the condition of eye diseases is still not known with certainty. The purpose of this study is to review the role of lacritin in eye diseases.
Methods: This study used literature from January 2001 until June 2023 according to the (Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). The literature was from electronic databases; PubMed, PubMed, WileyOnline, Science Direct, and Google Scholar. Full-text articles that evaluate the lacritin effect on bacterial corneal ulcers were included in this systematic review.
Results: A total of 26 studies were included in this review. Lacritin has a potential role in ZO1 expression (ZO1 is a type of protein structure in tight junction), which is essential for the corneal epithelium's structural integrity. Lacritin also induces tear protein secretion, which is an essential step in corneal ulcer healing.
Conclusion: Lacritin is potentially important in alternative modalities for bacterial corneal ulcers. However, a further study investigating the lacritin effect in corneal healing is suggested.
Epidermal growth factor receptor immunoreactivity in cervical squamous cell carcinoma and adenocarcinoma and its correlation with tumor characteristic
Authors: Dewi I Gusti Ayu Sri Mahendra , Sriwidyani Ni Putu , Ekawati Ni Putu Ekawati 
Published: January 2025

Link of Video Abstract: https://youtu.be/41nNqfCOjaE

Background: Cervical cancer is the second most common cancer in women and occupies 15% of all cancers in women. The most common types of cervical cancer are squamous cell carcinoma and adenocarcinoma. Epidermal Growth Factor Receptor (EGFR) plays a role in cell differentiation, motility, invasion, and metastasis. Therefore, this study aims to prove the difference in EGFR immunoreactivity in squamous cell carcinoma and adenocarcinoma of the uterine cervix and to prove the association between EGFR immunoreactivity and the degree of tumor differentiation.
Methods: This is a cross-sectional analytical observational study, using biopsy or surgery specimens from patients with squamous cell carcinoma and cervical adenocarcinoma, whose tissues were examined at the Anatomical Pathology Laboratory Universitas Udayana/ Prof. IGNG Ngoerah Hospital Denpasar. Histopathological diagnosis, determination of the type of malignancy, and the degree of differentiation were performed with Hematoxylin and Eosin (H & E) staining. EGFR expression was evaluated by immunohistochemical staining, and data analysis was conducted using a chi-square test.
Results: There was a significant difference in EGFR expression between squamous cell carcinoma and adenocarcinoma (p = 0.026). Squamous cell carcinoma has a risk of prevalence of high EGFR expression of 2.5 times compared to adenocarcinoma. Low EGFR expression was found in 4 (80%) samples of low-grade squamous cell carcinoma, and high EGFR expression in 12 (80%) samples of high-grade squamous cell carcinoma. There was a significant difference in EGFR expression between low and high-grade squamous cell carcinoma (p = 0.015). There were low EGFR expression in 8 (100%) samples of low-grade adenocarcinoma and high EGFR expression in 5 (41.7%) samples of high-grade adenocarcinoma. There was no significant difference in EGFR expression between low and high-grade adenocarcinomas (p = 0.055).
Conclusion: There was a significant difference in EGFR expression between squamous cell carcinoma and adenocarcinoma.
Sensitivity and specificity of thyroid ultrasound for follicular thyroid carcinoma
Authors: Hidayat Muhammad Furqan , Susilo Dwi Hari , Wibowo Marjono Dwi , Wihandono Asdi 
Published: January 2025

Link of Video Abstract: https://youtu.be/8J8wJ1fvuaY

Introduction: With the advancement of ultrasound examination technology in cases of thyroid nodule malignancy, several criteria and characteristic guidelines were developed, such as TIRADS (Thyroid Imaging, Reporting and Data System) criteria. These criteria assist clinicians in determining the diagnosis earlier than histopathological examination. The accuracy and sensitivity have been widely studied, but not much has been discussed regarding each characteristic item. This study aims to find the sensitivity, specificity, and accuracy of thyroid ultrasound examination against follicular-type thyroid carcinoma.
Method: This research is a retrospective cohort using medical record data of patients at Dr. Soetomo General Hospital Surabaya during the 5-year research period (2017-2021). The conclusion of USG results and characteristics of USG malignancy compared with histopathological results. The summary of USG results consists of TIRADS score, TIRADS score combined with nodule vascularization, TIRADS score combined with lymph node enlargement, and TIRADS score combined with lymph node location. USG characteristics consist of a solid nodule, microcalcification, irregular margin, nodule taller than wider, hypoechoic nodule, vascularization, enlargement of lymph node and location of lymph node
Result: The conclusion of USG results based on TIRADS, TIRADS combined with nodule vascularization, solid nodule characteristics, and lymph node enlargement characteristics have a strong relationship with malignant histopathology results (p-value <0.05), with the highest sensitivity in the conclusion of USG results, which is the TIRADS score combined with nodule vascularization (90.9%), the best specificity is almost the same in all scores, the best positive predictive value (PPV) (74.1%), negative predicted value (NPV) (80.0%) and accuracy (75,7%) is the TIRADS score combined with nodule vascularization. The characteristics of thyroid nodules are the characteristics that have the best sensitivity, namely 68.2%, specificity 68.7%, PPV 75%, NPV 58.8%, and accuracy level 67.5%
Conclusion: Ultrasonography (USG) results, solid nodule characteristics, enlarged lymph node characteristics and TIRADS score above 3 (3.5) can be used as predictors of malignancy in thyroid nodule cases earlier than histopathology results
Infiltration effect of ropivacaine on skin wound healing assessed by collagen density
Authors: Adjinegoro Lahuda , Sahudi  , Ghaib Husnul 
Published: January 2025

Link of Video Abstract: https://youtu.be/juiwFS3TxfA

Introduction: The wound healing process is characterized by granulation tissue rich in new blood vessel networks and macrophages, granulocytes, endothelial cells, and collagen that fill the wound gap. Ropivacaine infiltration, which can be used as a long-acting local anesthetic, is expected to reduce surgical stress. One of the parameters that can be used to assess wound healing is collagen density. Thus, it needs to be determined whether there are differences in the administration of ropivacaine as a local anesthetic in supporting the improvement of wound healing influenced by collagen density
Methods: This study was an experimental study using a sample of 32 Wistar rats (Rattus norvegicus) which were randomly divided into 2 groups: the treatment group with 2 cm full-thickness wound incisions with 2,52 mg of ropivacaine infiltration, while the control group was given NaCl infiltration 0.9% 1 ml. Furthermore, wound tissue samples were taken on day 5 to calculate Collagen density through immunohistochemical examination.
Results: Anesthetic infiltration of post-surgical wounds can accelerate wound healing. There was a significant difference in collagen density between the control and treatment groups (p = 0.028) and a significant difference between the control and treatment groups (p = 0.011).
Conclusion: The infiltration of ropivacaine in wound healing increases the density of collagen and fibroblasts, triggering the formation of granulation tissue that supports the wound healing process.
The management of ovarian cancer in pregnancy: a rare case report
Authors: Praja Dewangga Wahyu , Primandono Perbowo  
Published: January 2025

Link of Video Abstract: https://youtu.be/gGzNJpCiosc

Introduction: Ovarian tumors are found in approximately 1 in 1000 pregnancies. The simultaneous management of three separate yet interconnected entities: the mother, the fetus, and the disease complicates cancer care during pregnancy. The treatment of a pregnant woman with ovarian cancer is described in this paper.
Case Presentation: A 24-year-old pregnant lady (G2P0A1, 24 weeks gestational age, [GA]) was brought to our hospital after a routine prenatal ultrasound revealed a 15x18 cm left adnexal tumor. We discovered the complex adnexal mass, which was approximately 20x13.3x16 cm in size, in the left ovary, producing severe bilateral hydronephrosis on magnetic resonance imaging (MRI). The laboratory tests performed were within normal limits except for higher serum lactate dehydrogenase levels. At 34 weeks GA, the pregnancy was terminated via cesarean section. The baby (female, 1,600 g) was born alive with no congenital defects and an Apgar score of 3-5-7. Following that, a unilateral salpingo-oophorectomy was performed. Pathology indicated a high-grade serous carcinoma of the left ovary with positive ascites fluid but no evidence of metastases to the pelvic lymph nodes, omentum, or peritoneum (stage IC). We had planned to treat the woman with a paclitaxel-carboplatin combination, but she declined because she preferred to breastfeed her infant. She had no abdominal issues at 15 months and was still breastfeeding the baby.
Conclusion: Pregnancy-related epithelial ovarian cancer is uncommon but is a possibility. Clinical findings, diagnostic, and treatment strategies are roughly similar to non-pregnant patients, except for the timing of chemotherapy initiation. Further research is needed to give evidence regarding these mother-infant dyads' survival and health outcomes.
Assessment of factors associated with NLR, PWR, PLR, and LMR values in COVID-19 patients
Authors: Wikanningtyas Tri Ariguntar , Fachri Muhammad , Shabariah Rahmini , Resdyanugraha Diaz 
Published: January 2025

Link of Video Abstract: https://youtu.be/t7r9Nvg_-q0

Background: Coronavirus Disease 19 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Parameters that support the diagnosis and assess the immune status and inflammation process crucial for the prognosis of COVID-19 patients include Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Platelet to White Blood Cell Ratio (PWR), and Lymphocyte Monocyte Ratio (LMR). Age and comorbidities can also influence these values. This study assesses factors associated with NLR, PWR, PLR, and LMR values.
Methods: A cross-sectional study using the medical records of confirmed COVID-19 patients in Rumah Sakit Islam Jakarta Cempaka Putih and Sukapura from July to December 2020, with a total sample of 229 taken through a total sampling technique. For each patient, patient characteristics, including age, gender, comorbidity history, hospitalization, in-hospital death, NLR, PWR, PLR, and LMR values, were collected. Then, the relationship between these patient characteristics and NLR, PWR, PLR, and LMR values was analyzed using the chi-square test with SPSS version 22.0 for Windows.
Results: Patients aged 60 and above (84.7%) with a median age of 48 years, comorbidities (54.7%), in hospitalized non-ICU (92.3%), and mostly survivors (94.9%). Age is associated with NLR, PWR, PLR, and LMR values; gender is associated with LMR values, and comorbidity and hospitalization are associated with NLR, PLR, and LMR values. In-hospital death is not associated with these four values.
Conclusion: Age is associated with NLR, PWR, PLR, and LMR values, underscoring the importance of considering age as a critical factor in patient risk assessment and care. Medical teams should consider age-related differences in patient management and monitoring, especially for older patients.
Cuprum insertion in Cavernous Hemangioma: a case report
Authors: Purnama I Made Candra , Susilo Dwi Hari 
Published: January 2025

Link of Video Abstract: https://youtu.be/LCgbzk6OYuo

Background: Hemangioma is the most common benign vascular tumor in infants and young children. Early treatment of hemangioma may potentially prevent complications. Various treatment approaches for hemangiomas have been reported and widely used, including a wait-and-see policy, laser treatment, drug treatment, sclerotherapy, radiotherapy, and surgery. However, no treatment can be used for all hemangiomas. The use of copper wire might be used as an alternative therapy for cavernous hemangioma.
Case Presentation: A 21-year-old male complained of a reddish, rubbery, and pulsating lump on the left cheek and neck. Physical examination and radiologic examination were performed to diagnose the patient. A suspicion of vascular lesions was made. A copper wire insertion approach was used for therapy management.
Conclusion: The use of percutaneous copper needles to induce therapeutic coagulation is an effective option for cavernous hemangioma treatment
Analysis of sociodemographic factors associated with adverse drug-drug interaction in patients with stable angina pectoris prescribed polypharmacy at outpatient cardiology clinic Ulin Public Hospital Banjarmasin
Authors: Akhlis Fuad Fajar , Bakhriansyah Mohammad , Yustikasari Intan , Nurikhwan Pandji Winata , Adiputro Dwi Laksono 
Published: January 2025

Link of Video Abstract: https://youtu.be/K2LLRuJLoco

Background: Drug interactions can lead to either adverse or beneficial effects due to concomitant administration of drugs. The prevalence of drug interactions in patients with cardiovascular diseases has been reported to be high by 83-91%, especially in stable angina pectoris (SAP) patients. Various sociodemographic factors, including age, sex, education level, occupation, marriage status, and hypertension status, have been identified to influence drug interactions. This study aims to determine sociodemographic factors (age, sex, educational background, occupational status, marital status, and history of hypertension) that influence adverse drug-drug interactions in patients with SAP by using medical records.
Methods: It was a retrospective observational study with a cross-sectional approach conducted at the Outpatient Cardiology Clinic, Ulin Public Hospital Banjarmasin, Indonesia, from 2020 to 2021. The drug-drug interactions were determined by using the Lexicomp tool from the UpToDate® website. Prevalence odds ratios (PORs) and 95% confidence intervals (95%CI) were calculated using a logistic regression test.
Results: We identified 84 SAP patients prescribed 335 drug-drug interactions. Most patients were prescribed major polypharmacy (44 patients, 52.38%), and most interactions were under category C, i.e., close monitoring of therapy (220 interactions, 65.67%). Our study demonstrated that a year increase in age was associated with a significantly increased event of adverse drug-drug interaction by 1.106 times (adjusted POR 1.106, 95%CI 1.003-1.220, p=0.043).
Conclusion: In conclusion, among any other sociodemographic factors, only age was significantly associated with an increased event of adverse drug-drug interactions among SAP patients with polypharmacy at Ulin Public Hospital Banjarmasin, Indonesia.
Mortality prevalency of trauma patients with COVID-19 infection who underwent tracheostomy at dr. Soetomo General Hospital in 2022 – 2023
Authors: Adjinegoro Lahuda , Wibowo Maryono Dwi 
Published: January 2025

Link of Video Abstract: https://youtu.be/DzBbHSVJGxI

Introduction: A tracheostomy procedure may be necessary to speed up the weaning process because of the high prevalence of endotracheal extubation and ventilator weaning failure during the COVID-19 pandemic. In trauma patients, severe respiratory failure, upper airway blockage, inability to wean off mechanical ventilation, and copious secretions are common reasons for tracheostomy procedures. This study aims to examine the prevalence of mortality of trauma patients with COVID-19 who are undergoing tracheostomy to see if tracheostomy can help the therapy of trauma cases, especially for weaning from mechanical ventilation and airway complications.
Methods: This research is a descriptive observational study. We used the cross-sectional method to collect data. Information was extracted from the medical records of COVID-19 trauma patients who had tracheostomies at Dr. Soetomo General Hospital, Surabaya, between January 2022 and December 2023. A descriptive data analysis was conducted to determine each research variable's frequency and proportion. Version 26 of the IBM Statistics Desktop Software (SPSS) was used for this investigation.
Results: 50 trauma patients underwent tracheostomy at Dr. Soetomo General Hospital, consisting of 33 male and 17 female patients. Of these 50 patients, 12 had positive covid-19 and 38 had negative covid-19. Of the total 50 patients who underwent tracheostomy, 30 patients died, while 20 patients lived.
Conclusion: The prevalence of mortality in COVID-19 patients with tracheostomy treated at RSUD Dr. Soetomo Surabaya from 2022 to 2023 was 60%. Of the 50 patients, 28% of patients with positive covid-19 status were obtained, and 72% of patients had negative covid-19 status.
Prognostic factors of peritoneal dialysis-related to peritonitis at Hasan Sadikin General Hospital, Bandung, Indonesia
Authors: Kurniawan Aninditho Dimas , Tjahjodjati  
Published: January 2025

Link of Video Abstract: https://youtu.be/qhS-THemVqM

Background: Peritoneal dialysis (PD)-associated peritonitis is the most concerning PD-related infection as it carries significant morbidity, mortality, and added treatment costs and is a leading cause of PD technique failure. Many factors are linked to an increase in the risk of mortality peritonitis-related CAPD, but the data were inconsistently reported. Our study was conducted to determine the association between the onset of peritonitis and prognostic factors related to CAPD patients.
Methods: This was a retrospective observational cohort study. Nineteen peritonitis-related CAPD patients (8.40%) were screened from 226 patients who underwent CAPD insertion at Hasan Sadikin General Hospital, Bandung West Java, between January 2016 and December 2021. Patients included in this study were 18 or older, and those with incomplete medical records were excluded. Statistical methods used Fisher exact and Kolmogorov-Smirnov for categorical data. Chi-square tests were used to test relative risk and prognostic factors.
Results: A total of 19 patients (early onset of peritonitis, n = 16; late onset of peritonitis, n = 3) were analyzed in our study, with most of the subjects between 35-50 years old, consisting of males 63.2% and 12 patients (63.2%) with CAPD insertion by open technique. Patients who were underweight or overweight had an increased risk of peritonitis (RR 1.288 and 0.833, respectively, p=0.047). There was a significant association between diabetes melitus with increased risk of peritonitis (RR 1.157 p=0.041).
Conclusion: This study showed that early-onset peritonitis patients are related to poorer prognosis compared to late-onset peritonitis. Diabetes Mellitus and underweight or overweight were significantly increasing poor prognostic factors of peritonitis-related CAPD patients.
Alpha-blocker administration after Transurethral Resection of Prostate (TURP) procedure
Authors: Ardiansyah Novan , Abriansyah Aryo Teguh , Santoso Jumadi 
Published: January 2025

Link of Video Abstract: https://youtu.be/bcavIohiMKI

Background: Benign prostatic hyperplasia (BPH) is one of the most prevalent urological conditions that affect aging men. Alpha-1 adrenergic receptor inhibition medications such as Tamsulosin treat the dynamic component of benign prostatic hyperplasia. Transurethral Resection of the Prostate (TURP) is a procedure for patients who meet relative or absolute indications for surgery. This study aims to investigate whether the administration of Alpha blocker prevents acute urinary retention in patients post-TURP.
Methods: This is a randomized experimental study. The inclusion criteria include BPH patients and post-TURP procedures. A total of 60 Patients were divided into 2 groups: a tamsulosin group (30 patients) and a placebo group (30 patients). The urinary catheter was removed two days after the procedure. The patient followed up with an episode of urinary retention until seven days after the procedure. Data were analyzed using SPSS version 26.0 for Windows.
Results: There was 10% (3 of 30 patients) from the first group (Tamsulosin group) and 6.6% (2 of 30 patients) from the second group (placebo group) experienced urinary retention. Both patients from the second group experienced immediate acute urinary retention after the urinary catheter was removed. In the first group, the first patient experienced urinary retention on the fifth day, and the second and third patients experienced urinary retention on the seventh day.
Conclusion: Administration of Alpha-blocker (Tamsulosin 0.4mg) had no significant benefit in preventing acute urinary retention in patients post-TURP.