bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study on Body Composition, Blood Pressure and Blood Sugar Levels Among Bengali Hindu and Santals Using Cultural Consonance Model
Authors: Kanrar Priyanka , Som Nivedita , Roy Subho 
Published: April 2021

We examined how the perception/beliefs towards lifestyle and the actual lifestyle are related to body composition, blood pressure and blood sugar levels among Santals and Hindu caste populations using the cultural consonance model. The study involved 210 individuals (109 Bengali Hindu and 101 Santals), aged 18–50 years living in the city of Howrah, West Bengal, India. Principal component analyses were performed to extract the components from the variables used in perception towards lifestyle. Multiple linear regression analyses and multivariate analysis of covariance were used to understand association of body composition, blood pressure and blood sugar levels with both the perception towards and actual lifestyle and ethnicity, respectively. Results showed that there is a difference between perception towards and actual pattern of lifestyle among the members of two ethnic groups, indicating low cultural consonance. However, both the variables were associated with body composition, blood pressure and blood sugar levels, but not ethnicity, after removing the effects of socio-demographic and lifestyle variables. We conclude that shared knowledge and perception towards healthy lifestyle among individuals, perhaps encoded in own culture, often fail to get translated in actual lifestyle pattern and eventually affect physical health.
LSD1 defines erythroleukemia metabolism by controlling the lineage-specific transcription factors GATA1 and C/EBPα
Authors: Kohrogi Kensaku , Hino Shinjiro , Sakamoto Akihisa , Anan Kotaro , Takase Ryuta , Araki Hirotaka , Hino Yuko , Araki Kazutaka , Sato Tetsuya , Nakamura Kimitoshi , Nakao Mitsuyoshi 
Published: April 2021

Abstract
Acute myeloid leukemia (AML) is a heterogenous malignancy characterized by distinct lineage subtypes and various genetic/epigenetic alterations. As with other neoplasms, AML cells have well-known aerobic glycolysis, but metabolic variations depending on cellular lineages also exist. Lysine-specific demethylase-1 (LSD1) has been reported to be crucial for human leukemogenesis, which is currently one of the emerging therapeutic targets. However, metabolic roles of LSD1 and lineage-dependent factors remain to be elucidated in AML cells. Here, we show that LSD1 directs a hematopoietic lineage-specific metabolic program in AML subtypes. Erythroid leukemia (EL) cells particularly showed activated glycolysis and high expression of LSD1 in both AML cell lines and clinical samples. Transcriptome, chromatin immunoprecipitation–sequencing, and metabolomic analyses revealed that LSD1 was essential not only for glycolysis but also for heme synthesis, the most characteristic metabolic pathway of erythroid origin. Notably, LSD1 stabilized the erythroid transcription factor GATA1, which directly enhanced the expression of glycolysis and heme synthesis genes. In contrast, LSD1 epigenetically downregulated the granulo-monocytic transcription factor C/EBPα. Thus, the use of LSD1 knockdown or chemical inhibitor dominated C/EBPα instead of GATA1 in EL cells, resulting in metabolic shifts and growth arrest. Furthermore, GATA1 suppressed the gene encoding C/EBPα that then acted as a repressor of GATA1 target genes. Collectively, we conclude that LSD1 shapes metabolic phenotypes in EL cells by balancing these lineage-specific transcription factors and that LSD1 inhibitors pharmacologically cause lineage-dependent metabolic remodeling.
Restoring a butterfly hot spot by large ungulates refaunation: the case of the Milovice military training range, Czech Republic
Authors: Konvička Martin , Ričl David , Vodičková Veronika , Beneš Jiří , Jirků Miloslav 
Published: April 2021

AbstractBackgroundRefaunation/rewilding by large ungulates represents a cost-efficient approach to managing natural biotopes and may be particularly useful for areas whose biodiversity depends on disturbance dynamics and is imperilled by successional changes. To study impacts of refaunation on invertebrates, we focused on butterflies inhabiting the former military training range Milovice, Czech Republic, refaunated since 2015 by a combination of Exmoor pony (“wild” horse), Tauros cattle (“aurochs”), and European wisent.MethodsWe analysed butterfly presence-absence patterns immediately after the military use termination (early 1990s), prior to the refaunation (2009), and after it (2016–19); and current abundance data gained by monitoring butterflies at refaunated and neglected plots. We used correspondence analysis for the presence-absence comparison and canonical correspondence analysis for the current monitoring, and related results of both ordination methods to the life history and climatic traits, and conservation-related attributes, of recorded butterflies.ResultsFollowing the termination of military use, several poorly mobile species inclining towards oceanic climates were lost. Newly gained are mobile species preferring warmer continental conditions. The refaunated plots hosted higher butterfly species richness and abundances. Larger-bodied butterflies developing on coarse grasses and shrubs inclined towards neglected plots, whereas refaunated plots supported smaller species developing on small forbs.ConclusionThe changes in species composition following the cessation of military use were attributable to successional change, coupled with changes in species pool operating at larger scales. By blocking succession, large ungulates support butterflies depending on competitively poor plants. Restoring large ungulates populations represents a great hope for conserving specialised insects, provided that settings of the projects, and locally adapted ungulate densities, do not deplete resources for species with often contrasting requirements.
Massive hemothorax in a pregnant patient with neurofibromatosis type 1
Authors: Hashimoto Kumiko , Nomata Yuji , Fukui Takayuki , Takada Akira , Narita Kunio 
Published: April 2021

Abstract
Background
Reports of spontaneous hemothorax in patients with neurofibromatosis type 1 are scarce despite the severe complication. We herein present the first case of hemothorax in a neurofibromatosis type 1 patient during pregnancy and discuss the difficulty associated with its diagnosis and treatment.

Case presentation
A 39-year-old female at 34 weeks gestation presented with sudden left back pain and dyspnea. Chest radiography revealed massive left pleural effusion. Computed tomography showed bleeding from the intercostal artery. Although the patient appeared hemodynamically stable, the fetus was in a critical condition. Emergency caesarean section was performed within 1 hour. Subsequently, we performed endovascular coil embolization of the intercostal artery. While this intensive treatment saved the patient, her fetus could not be rescued.

Conclusions
Patients with neurofibromatosis type 1 may develop massive hemothorax without gross lesions. In late pregnancy, sufficient infusion and quick hemostasis are essential and can be lifesaving.
Thyroid hemiagenesis with a TI-RADS 2 nodule in the contralateral lobe
Authors: Sereke Senai Goitom , Oriekot Anthony , Bongomin Felix 
Published: April 2021

Abstract
Background
Thyroid hemiagenesis is a rare congenital anomaly in which one lobe of the thyroid gland fails to develop. There is an increased incidence of associated thyroid disorders in patients with thyroid hemiagenesis.

Case presentation
A 32-year-old Ugandan woman presented with a complaint of painless neck swelling of 3-months duration. The swelling was associated with a globus sensation. There was no history of thyroid – related problems or treatment prior to this presentation. Physical examination demonstrated a mobile right thyroid swelling without an obvious nodular contour. Neck ultrasound showed an absent left lobe of thyroid gland, a right lobe with a solitary nodule scoring two points on the Thyroid Imaging, Reporting and Data System (TI-RADS) and an isthmus in situ. Extensive search for possible ectopic thyroid tissue was negative. She was biochemically euthyroid. The patient was counseled about thyroid hemiagenesis and was put on a regular follow up in the clinic for the TI-RADS 2 nodule.

Conclusion
Thyroid hemiagenesis is often associated with other thyroid disorders. Its diagnosis should prompt an active search for other associated morphological or functional thyroid abnormalities.
Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
Authors:   NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed MESA Multi-Omics Working Group, Breeze Charles E. , Batorsky Anna , Lee Mi Kyeong , Szeto Mindy D. , Xu Xiaoguang , McCartney Daniel L. , Jiang Rong , Patki Amit , Kramer Holly J. , Eales James M. , Raffield Laura , Lange Leslie , Lange Ethan , Durda Peter , Liu Yongmei , Tracy Russ P. , Van Den Berg David , Evans Kathryn L. , Kraus William E. , Shah Svati , Tiwari Hermant K. , Hou Lifang , Whitsel Eric A. , Jiang Xiao , Charchar Fadi J. , Baccarelli Andrea A. , Rich Stephen S. , Morris Andrew P. , Irvin Marguerite R. , Arnett Donna K. , Hauser Elizabeth R. , Rotter Jerome I. , Correa Adolfo , Hayward Caroline , Horvath Steve , Marioni Riccardo E. , Tomaszewski Maciej , Beck Stephan , Berndt Sonja I. , London Stephanie J. , Mychaleckyj Josyf C. , Franceschini Nora 
Published: April 2021

Abstract
Background
DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poorly understood. We aimed to identify trans-ethnic and ethnic-specific differentially methylated positions (DMPs) associated with eGFR using an agnostic, genome-wide approach.

Methods
The study included up to 5428 participants from multi-ethnic studies for discovery and 8109 participants for replication. We tested the associations between whole blood DNAm and eGFR using beta values from Illumina 450K or EPIC arrays. Ethnicity-stratified analyses were performed using linear mixed models adjusting for age, sex, smoking, and study-specific and technical variables. Summary results were meta-analyzed within and across ethnicities. Findings were assessed using integrative epigenomics methods and pathway analyses.

Results
We identified 93 DMPs associated with eGFR at an FDR of 0.05 and replicated 13 and 1 DMPs across independent samples in trans-ethnic and African American meta-analyses, respectively. The study also validated 6 previously published DMPs. Identified DMPs showed significant overlap enrichment with DNase I hypersensitive sites in kidney tissue, sites associated with the expression of proximal genes, and transcription factor motifs and pathways associated with kidney tissue and kidney development.

Conclusions
We uncovered trans-ethnic and ethnic-specific DMPs associated with eGFR, including DMPs enriched in regulatory elements in kidney tissue and pathways related to kidney development. These findings shed light on epigenetic mechanisms associated with kidney function, bridging the gap between population-specific eGFR-associated DNAm and tissue-specific regulatory context.
The potential of adipokines in identifying multiple trauma patients at risk of developing multiple organ dysfunction syndrome
Authors: Haupt Julian , Krysiak Niels , Unger Marina , Bogner-Flatz Viktoria , Biberthaler Peter , Hanschen Marc , van Griensven Martijn , Haug Alexander T. 
Published: April 2021

AbstractBackgroundMultiple organ dysfunction syndrome (MODS) and the consecutive multiple organ failure (MOF) are severe and dreaded complications with a high mortality in multiple trauma patients. The aim of this study was to investigate the potential of the adipokines leptin, resistin, interleukin-17A and interleukin-33 as possible biomarkers in the early posttraumatic inflammatory response and for identifying severely traumatized patients at risk of developing MODS.MethodsIn total, 14 multiple trauma patients with an injury severity score (ISS) ≥ 16 as well as a control group of 14 non-multiple trauma patients were included in this study and blood samples were taken at the time points 0, 6, 24, 48 and 72 h after admission. For the trauma patients, the SIRS and Denver MOF score were determined daily. The quantitative measurement of the plasma concentrations of the adipokines was performed using ELISA.ResultsIn the statistical analysis, the multiple trauma patients showed statistically significant higher plasma concentrations of leptin, resistin, IL-17A and IL-33 compared to the control group. In addition, there was a statistically significant positive correlation between the concentrations of resistin, IL-17A and IL-33 and the corresponding SIRS scores and between the concentrations of resistin, IL-17A and IL-33 and the corresponding Denver MOF scores. Finally, ROC curve analysis revealed that the adipokines leptin and IL-17A are suitable diagnostic markers for the discrimination between multiple trauma patients with and without MOF.ConclusionsLeptin and IL-17A could be suitable diagnostic markers to identify severely injured patients with a developing SIRS and MOF earlier, to adjust surgical therapy planning and intensive care.
Physico-chemical and antioxidant properties of barberry juice powder and its effervescent tablets
Authors: Naji-Tabasi Sara , Emadzadeh Bahareh , Shahidi-Noghabi Mostafa , Abbaspour Mohammadreza , Akbari Ehsan 
Published: April 2021

Abstract
Background
Barberry fruit is a good source of natural antioxidants and various functional compounds. Different concentrations of maltodextrin (10, 13, and 16% w/w) were used to produce spray-dried barberry juice powder and the powders (50, 60, and 70%) were applied to create effervescent tablets.

Results
The results showed that by increasing the amount of maltodextrin concentration, moisture, and water activity decreased (p < 0.05), but antioxidant activity increased. The barberry powder prepared with 13% (w/w) maltodextrin showed appropriate flowability, color, high antioxidant activity, and phenol content. The presence of high amounts of barberry powder in the tablet increased the disintegration time (1.02–4.03 min).

Conclusions
The tablet containing 60% barberry powder was selected as the best sample. Based on the results, barberry tablets with good color, high antioxidant activity, and phenolic compounds can be used as a ‘ready-to-drink’ product.
Choroidal vascularity index in thyroid-associated ophthalmopathy: a cross-sectional study
Authors: Loiudice Pasquale , Pellegrini Marco , Marinò Michele , Mazzi Barbara , Ionni Ilaria , Covello Giuseppe , Figus Michele , Nardi Marco , Casini Giamberto 
Published: April 2021

Abstract
Background
Hemodynamic changes have been observed in patients with Graves’ disease. The aim of our study was to evaluate choroidal vascular change using the choroidal vascularity index (CVI) in patients with thyroid-associated ophthalmopathy (TAO).

Methods
In this cross-sectional observational study, 40 patients affected by TAO were recruited. Forty healthy individuals, matched for age and sex, served as controls. Foveal enhanced-depth imaging optical coherence tomography scans were obtained from all participants. Images were binarized using the ImageJ software and luminal area (LA) and total choroidal area (TCA) were measured. CVI was calculated as the proportion of LA to TCA. The relation between CVI or subfoveal choroidal thickness (SFCT) and clinical activity score, exophthalmometric value, diplopia status, gender, and age was evaluated.

Results
CVI was significantly higher in patients with TAO (P = 0.004). No significant difference was observed in SFCT (P = 0.200) and TCA (P = 0.153) comparing TAO patients and healthy controls. LA was significantly higher in TAO group (P = 0.045). On multiple regression analysis, CVI was associated with TCA (P = 0.043). No association was found between SFCT or CVI and TCA, clinical activity score, exophthalmometric value, Inami value, diplopia status, gender or age (P > 0.05).

Conclusions
This is the first study that has demonstrated an increase in CVI in eyes with TAO compared with healthy controls and has assessed its association with clinical features.
Dental implant status in elderly individuals requiring domiciliary dental care in Japan
Authors: Hagiwara Yoshiyuki , Ohyama Tetsuo , Yasuda Hiroyasu , Seki Keisuke , Ikeda Takayuki 
Published: April 2021

Abstract
Background
The presence of implants is a significant burden not only for dentists but also for caregivers and families of elderly individuals requiring nursing and domiciliary dental care. However, few reports have assessed the status of domiciliary dental care or measures employed to deal with related issues. Hence, we aimed to evaluate the dental implant status in elderly patients requiring nursing and domiciliary dental care and to determine the suitable measures for overcoming the associated limitations. A questionnaire was mailed to 1000 dentists who provided domiciliary dental care in the Tokyo metropolitan area of Japan. The questions were classified into three categories: basic information of the dentists, actual implant status of patients requiring domiciliary dental care, and implants in an aging society.

Results
The response rate was 36.5%. Approximately 2% of patients requiring domiciliary dental care were implant patients. Many implant-related problems were associated with insufficiency or difficulty in cleaning around the implant, resulting in peri-implantitis. Prosthetic and more serious complications such as implant body fracture or loss were reported and frequently managed by routine follow-ups, cleaning the area around the implant, scaling and polishing, and/or pharmacological modalities. Oral care mainly involved simple toothbrushing instructions, which was not adequate.

Conclusions
Our findings suggest the necessity of simplifying the oral environment and making oral care a simple task before aging individuals require nursing and domiciliary dental care.
Optimising psychological treatment for Anxiety DisordErs in Pregnancy (ADEPT): study protocol for a feasibility trial of time-intensive CBT versus weekly CBT
Authors: Challacombe Fiona L. , Potts Laura , Carter Ben , Lawrence Vanessa , Husbands Alaina , Howard Louise M. 
Published: April 2021

Abstract
Background
Moderate to severe anxiety disorders such as obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), social phobia and panic disorder are common, and affect approximately 11–16% of women in pregnancy. Psychological treatments for anxiety disorders, primarily cognitive behaviour therapy (CBT), have a substantial evidence base and recently time-intensive versions have been found as effective as weekly treatments. However, this has not been trialled in women who are pregnant, where a shorter intervention may be desirable.

Methods
The ADEPT study is a feasibility randomised controlled trial with two parallel intervention groups. Time-intensive one-to-one CBT and standard weekly one-to-one CBT delivered during pregnancy will be compared. Feasibility outcomes including participation and follow-up rates will be assessed, alongside the acceptability of the interventions using qualitative methods.

Discussion
The study will provide preliminary data to inform the design of a full-scale randomised controlled trial of a time-intensive intervention for anxiety during pregnancy. This will include information on the acceptability of time-intensive interventions for pregnant women with anxiety disorders.

Trial registration
10.1186/ISRCTN81203286 prospectively registered 27/6/2019.
Attenuation of glycation and biochemical aberrations in fructose‐loaded rats by polyphenol‐rich ethyl acetate fraction of Parkia biglobosa (jacq.) Benth. (Mimosaceae) leaves
Authors: Chibuogwu Christian Chiazor , Asomadu Rita Onyekachukwu , Okagu Innocent Uzochukwu , Nkwocha Chinelo C , Amadi Ben Chibuzo 
Published: April 2021

Abstract
Background
Different parts of the Parkia biglobosa plant are employed in traditional medicine in different African communities. However, information ratifying its use and biochemical influence on health is still scanty in literature. Thus, the present study assessed the influence of the ethyl acetate fraction of Parkia biglobosa leaves (EAFPB) on some biochemical parameters of sub-chronic fructose-loaded rats.

Methodology
Twenty-five Wistar rats were randomized into five groups (n = 5). The normal control group was maintained on normal diet only while the high fructose solution (HFS) control (placebo), reference and treatment groups received high fructose solution (3 g/kg/d b.w of fructose) for 30 days before treatment. Based on pilot study, two doses (100 and 200 mg/kg/d b.w) of EAFPB were selected and were administered to two groups of test animals while the reference group received 300 mg/kg/d b.w. of metformin for 14 days. Thereafter, blood was collected from fasted animals for biochemical analyses for the examination of level of glycated hemoglobin (HbA1c), liver status (alanine and aspartate aminotransferases (ALT and AST) and alkaline phosphatase (ALP) activities, and bilirubin level), lipid profile (total cholesterol, triglyceride, and low- and high-density lipoproteins levels) and lipid peroxidation (malondialdehyde – MDA level).

Results
EAFPB was shown to have a good DPPH radical scavenging activity (EC50 = 0.395 mg/ml). Chromatographic analysis of EAFPB revealed 28 known flavonoids (mainly kaempferol (21.31 mg/100 g), quercetin (12.84 mg/100 g), and luteolin (6.75 mg/100 g)), four hydrocinnamic acids derivatives (mainly P-coumaric acid (6.73 mg/100 g)), and 11 phenolic acids derivatives (mainly chlorogenic acid (48.18 mg/100 g) and protocatechuic acid (21.58 mg/100 g)). Relative to normal control, it was observed that fructose overload significantly increased serum activities of ALP, ALT, and AST, and levels of MDA, total cholesterol, low density lipoprotein and triglyceride in placebo. However, EAFPB significantly tapered the elevated serum activities of ALP, ALT, and AST. In addition, relative to placebo, the increased levels of HbA1c, MDA, and lipid health markers were also rebated by EAFPB.

Conclusions
Ethyl acetate fraction of Parkia biglobosa leaves attenuates biochemical aberrations in fructose-loaded rats, an effect attributable to the rich store of polyphenolic compounds in the fraction.

Graphical abstract
Reframing ‘integration’: acknowledging and addressing five core critiques
Authors: Spencer Sarah , Charsley Katharine 
Published: April 2021

AbstractEmpirical and theoretical insights from the rich body of research on ‘integration’ in migration studies have led to increasing recognition of its complexity. Among European scholars, however, there remains no consensus on how integration should be defined nor what the processes entail. Integration has, moreover, been the subject of powerful academic critiques, some decrying any further use of the concept. In this paper we argue that it is both necessary and possible to address each of the five core critiques on which recent criticism has focused: normativity; negative objectification of migrants as ‘other’; outdated imaginary of society; methodological nationalism; and a narrow focus on migrants in the factors shaping integration processes. We provide a definition of integration, and a revised heuristic model of integration processes and the ‘effectors’ that have been shown to shape them, as a contribution to a constructive debate on the ways in which these challenges for empirical research can be overcome.