bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of psychological counseling and acupressure based on couple therapy procedure for alleviation of vomiting and nausea in pregnant women in Iran country
Authors: Saadatnia Sahar , Tiznobaik Azita , Saber Amir 
Published: May 2021

Abstract

Objectives
Nausea and vomiting have psychological negative effects on some pregnant women during gestation. Different strategies have been used for the treatment of nausea and vomiting during pregnancy, such as acupressure and psychological interventions. This study was conducted to evaluate the effects of psychological counseling and acupressure based on couple therapy procedures on vomiting and nausea in pregnant women in Iran.

Methods
Two hundred and eight women were divided into four groups (n=52): 1) they did not any intervention (control group), 2) they received the psychological intervention, 3) they received acupressure intervention, and 4) they received a combination of psychological + acupressure interventions. To investigate the effects of interventions on nausea and vomiting, the Rhodes index of nausea, vomiting and retching were used. The counseling period has lasted for 4 weeks. The pressure intervention on the site was conducted in clockwise form for 1 min and anticlockwise form for another 1 min.

Results
Groups did not have a significant difference for abortion and income (p>0.05). The effects of counseling, and acupressure interventions on severity and period of vomiting and nausea were not significant (p>0.05), but the intervention based on counseling and acupressure decreased severity of vomiting and nausea (p<0.05).

Conclusions
The intervention based on counseling and acupressure could not reduce nausea and vomiting during the gestation, but the intervention based on a combination of both decreased nausea and vomiting. It can be suggested to apply an intervention based on a combination of counseling and acupressure in short-time period for decreasing nausea and vomiting in women during pregnancy.
Effect of Arjun

Ch

āl on cardiovascular risk factors – a randomized controlled clinical trial
Authors: Saleem Saima , Ansari Abdul Haseeb , Ansari Aysha 
Published: May 2021

Abstract

Objectives
Cardiovascular diseases have a multifaceted, it causes modern epidemic; Recognizing in the risk factor stage, is crucial, given the risk of progression to cardiovascular disease. Ibn Sīnā, described CVDs as a resultant of gradual derangement of Quwwat ghādhiya (Nutritive faculty); in which management with ghidhā’ (diet), tadābīr (regimens), dawā’ (drug) has been received. To evaluate the effect of Arjun Chāl (Terminalia arjuna) in CVD risk factors. And to evaluate the drug safety.

Methods
This is a randomized controlled clinical trial. Total 120 patients were screened at OPD of NIUM hospital, Bangalore during 2018–19, only 48 patients fulfilled the inclusion criteria and signed written informed consent and their detailed medical history was recorded. Arjun Chāl powder (5 gm BD) for eight weeks administered in test group (n=24), Amlodipine (5 mg) and Atorvastatin (10 mg) once a day for same duration administered in control group (n=24). Efficacy of the drug assessed by the Lipid profile, BP and BMI; lipid profile were performed at baseline and at 8 weeks, while BP and BMI performed at baseline, 15, 30, 45, and 60th day intervals. Study was completed by 40 patients. The results of both the therapies were then compared and statistically analyzed.

Results
Totally, both groups reduces assessment parameters i.e. statistically highly significant (p<0.001). Test group showed greater reduction in terms of all assessment parmeters. But, the difference between both the groups was statistically non-significant p>0.05.

Conclusions
Both test and control drugs were effective, but Arjun Chāl had a slight edge over amlodipne and atorvastatin, and was found to be safe and well tolerated. It has a cardio protective potential and hence effective to delay/prevent CVD in patient with cardiovascular risk factor.Keywords: Unani System of Medicine; T. arjuna; Arjun Chāl; Efficacy; Safety; Cardiovascular risk factor.
The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
Authors: Iman Maryam , Taheri Mohammadreza , Bahari Zahra 
Published: May 2021

Abstract

Objectives
The neem (Azadirachta indica) have been used in herbal medicine for the treatment of multiple diseases, particularly cancer. The mechanism of anti-cancer properties of neem are far from clear. However, it is well accepted that anti-cancer effects of neem is mediated via its hepatic anti-oxidant activity. In the present review, we are going to classify in vitro and in vivo studies about anti-cancer activity of neem via its hepatic anti-oxidant activity. We also summarize its active ingredients and some therapeutic and toxic dosage forms.

Methods
A systematic search in the literature was performed in PubMed, Scopus, Embase, Cochrane Library, Web of Science, as well as Google Scholar pre-print database using all available MeSH terms for neem, A. indica, anti-cancer, anti-tumor, carcinogen, liver, antioxidant activity, neem ingredients, and glutathione. Electronic database searches combined and duplicates were removed.

Results
The neem plant have been used in herbal medicine for the treatment of various diseases, particularly cancer. The mechanisms of anti-cancer effects of neem are far from clear. Cancerous cells growth can induce imbalance the oxidant and anti-oxidant activity in various organs particularly in the liver. Therefore, it seems that neem have anti-cancer effects via restore of the antioxidant disturbances close to the control ones in the liver. Additionally, administration of neem extract can induce oncostatic potential via several mechanism including; suppression of the NF-κβ pathway, increased expression of tumor suppressor (such as p53 and pTEN), decreased expression of oncogenes (such as c-Myc), and increased apoptosis in cancerous cells. The median lethal dose (LD50) value for extracts of neem was higher than 2,500 mg/kg.

Conclusions
It is suggested that neem plays pivotal role in the prevention and treatment of cancer via its hepatic antioxidant activity. Indeed, application of neem extract can decreased tumor growth via restore of the antioxidant disturbances close to the control ones in the liver.
Non-Equilibrium Molecular Dynamics Study of the Influence of Branching on the Soret Coefficient of Binary Mixtures of Heptane Isomers
Authors: Chen Xiaoyu , Liang Ruquan , Wu Lichun , Cui Gan 
Published: May 2021

Abstract
Equimolar mixtures composed of isomers were firstly used to investigate the molecular branching effect on thermal diffusion behavior, which was not disturbed by factors of molecular mass and composition in this work. Eight heptane isomers, including n-heptane, 2-methylhexane, 3-methylhexane, 2,2-dimethylpentane, 2,3-dimethylpentane, 2,4-dimethylpentane, 3,3-dimethylpentane and 3-ethylpentane, were chosen as the researched mixtures. A non-equilibrium molecular dynamics (NEMD) simulation with enhanced heat exchange (eHEX) algorithm was applied to calculate the Soret coefficient at

T
=
303.15

T=303.15

K and

P
=
1.0

atm

P=1.0\hspace{0.1667em}\text{atm}

. An empirical correlation based on an acentric factor was proposed and its calculation coincides with the simulated results, which showed the validity of the NEMD simulation. It is demonstrated that the isomer with higher acentric factor has a stronger thermophilic property and tends to migrate to the hot region in the heptane isomer mixture, and the extent of thermal diffusion is proportional to the difference between the acentric factors of the isomers.
Arne Bjerhammar- a personal summary of his academic deeds
Authors: Sjöberg L. E. 
Published: May 2021

Abstract
Arne Bjerhammar is well known worldwide mainly for his research in physical geodesy but also for introducing a new matrix algebra with generalized inverses applied in geodetic adjustment. Less known are his developments in geodetic engineering and contributions to satellite and relativistic geodesy as well as studies on the relation between the Fennoscandia land uplift and the regional gravity low. Most likely part of his research has contributed to worldwide political relaxation during the cold war, which deed was honored by a certificate of achievement awarded by the Department of Research of the US army as well as the North Star Order by the King of Sweden.
Arne Bjerhammar’s pioneer scientific production, in particular on a world geodetic system, towards what would become GPS, as well as relativistic geodesy, is still of great interest among the worldwide geodetic community, while the memories and spirit along his outstanding academic deeds have more or less fainted away from his home university (KTH) only a decade after he passed away.
NDRG2 inhibition facilitates angiogenesis of hepatocellular carcinoma
Authors: Wang Jianlong , Li Tao , Ma Lifeng , Liu Guochao , Wang Guiying , Kang Jiansheng 
Published: May 2021

Abstract
Hepatocellular carcinoma (HCC) is an angiogenesis-dependent tumor, and angiogenesis plays pivotal roles in progression and hematogenous metastasis. Upregulating NDRG2 expression could inhibit endothelial cell proliferation and tumor angiogenesis. However, the development of angiogenesis is a complicated and dynamic process, and the specific mechanisms that NDRG2 influences its progression are largely unknown. Conditioned media (CM) was collected from HCC cells. Cell viability, migration assay, tube formation, and western blot were used to evaluate the effect of NDRG2 on angiogenesis in HCC cells. ELISA assay was used to measure the level of VEGFA in CM. CM from NDRG2 knockdown cells significantly promoted HUVECs proliferation, migration, and tube formation compared with control cells. The level of VEGFA in CM was increased by NDRG2 knockdown relative to the control group. The expression of VEGFA, HIF-1α, and p-Akt was significantly increased in NDRG2 knockdown cells. CM from NDRG2 knockdown cells with VEGFA antibody failed to induce HUVEC proliferation, migration, and tube formation. YC-1 significantly inhibited the level of VEGFA in CM from NDRG2 knockdown cells. YC-1 also inhibited the expression of VEGFA and HIF-1α. Therefore, NDRG2 inhibition promoted the angiogenesis of HCC via VEGFA and may be used to be an anti-angiogenesis target.
Nomogram prediction model for renal anaemia in IgA nephropathy patients
Authors: Li Fei , Wei Ri-bao , Wang Yang , Su Ting-yu , Li Ping , Huang Meng-jie , Chen Xiang-mei 
Published: May 2021

Abstract
In this study, we focused on the influencing factors of renal anaemia in patients with IgA nephropathy and constructed a nomogram model. We divided 462 patients with IgA nephropathy diagnosed by renal biopsy into anaemic and non-anaemic groups. Then, the influencing factors of renal anaemia in patients with IgA nephropathy were analysed by least absolute shrinkage and selection operator (LASSO) regression and multivariable logistic regression, and a nomogram model for predicting renal anaemia was established. Eventually, nine variables were obtained, which are easy to apply clinically. The areas under the receiver operating characteristic (ROC) curve and precision-recall (PR) curve reached 0.835 and 0.676, respectively, and the C-index reached 0.848. The calibration plot showed that the model had good discrimination, accuracy, and diagnostic efficacy. In addition, the C-index of the model following internal validation reached 0.823. Decision curve analysis suggested that the model had a certain degree of clinical significance. This new nomogram model of renal anaemia combines the basic information, laboratory findings, and renal biopsy results of patients with IgA nephropathy, providing important guidance for predicting and clinically intervening in renal anaemia.
Die Begrenzung überragender Marktmacht digitaler Plattformen im deutschen und europäischen Wettbewerbsrecht
Authors: Haucap Justus , Schweitzer Heike 
Published: May 2021

Zusammenfassung
In diesem Beitrag beschreiben Justus Haucap und Heike Schweitzer die wesentlichen Änderungen im deutschen Kartellrecht, die in Bezug auf die Begrenzung der Marktmacht digitaler Plattformen mit der 10. Novelle des Gesetzes gegen Wettbewerbsbeschränkungen (GWB) im Januar 2021 verabschiedet wurden. Diese Änderungen vergleichen sie mit den Vorschlägen für einen Digital Markets Act (DMA), welche die Europäische Kommission im Dezember 2020 vorgelegt hat. Zudem erörtern sie das Problem der sogenannten Killerakquisitionen, auf das weder die GWB-Novelle noch der Vorschlag für einen DMA eingeht.
Semen testis expressed protein 101 and spermatid-specific thioredoxin reductase 3 levels may be biomarkers in infertile male
Authors: Erbayram Fatma Zehra , Menevse Esma , Dursunoglu Duygu 
Published: May 2021

Abstract

Objectives
We aimed to determine the differences between normozoospermic and oligozoospermic individuals according to levels of spermatid-specific thioredoxin reductase 3 (SPTRXR3/STRX3/TXNDC8/TXNRD3) and testis expressed protein 101 (TEX-101), and to evaluate the correlations between spermiogram data and biochemical parameters.

Methods
The study was carried out at the Andrology Laboratory of Medicine Faculty of Selcuk University. Two groups were designed: Group 1: Normozoospermia (n=40, sperm concentration ≥ 15 million/mL), Group 2: Oligozoospermia; (n=40, sperm concentration < 15 million/mL). Seminal plasma SPTRXR3 and TEX-101 levels were analyzed with ELISA method. Spermiogram analysis was evaluated according to WHO 2010 Kruger criteria.

Results
TEX-101 protein levels were significantly different in normozoospermia (2.12 ± 0.08 ng/mL) compared to oligozoospermia (1.55 ± 0.04 ng/mL). SPTRXR3 levels (6.98 ± 0.46 ng/mL) were higher in oligozoospermia than normozoospermia (3.07 ± 0.35 ng/mL). Both TEX-101 and SPTRXR3 levels were correlated statistically with most of the spermiogram parameters.

Conclusions
High SPTRXR3 and low TEX-101 levels may be a biomarker in evaluation of male infertility. The relations between spermiogram parameters indicates that results present a new clinical approach in biology of oligozoospermic male.
The role of zonulin in the pathogenesis of diabetic retinopathy
Authors: Sirin Fevziye Burcu , Korkmaz Hakan , Torus Bora , Bozkurt Mustafa , Kumbul Doguc Duygu 
Published: May 2021

Abstract

Objectives
To evaluate serum levels of zonulin and interleukin 6 (IL-6) in type 2 diabetes mellitus (T2DM) patients complicated by diabetic retinopathy and to investigate the effect of intestinal permeability on diabetic retinopathy (DR) progression.

Materials and Methods
Eighty-nine patients with T2DM and 30 healthy controls aged between 18 and 80 years were enrolled. T2DM patients were grouped as without DR (n=30), with non-proliferative DR (n=29), and with proliferative DR (n=30). Serum zonulin and IL-6 levels were measured with the ELISA method.

Results
Zonulin levels showed no statistical difference by pairwise comparisons of groups, but IL-6 levels were significantly increased in non-proliferative and proliferative DR groups compared to the HC and without DR groups. Zonulin level was correlated with body mass index and IL-6 level; IL-6 level was correlated with duration of diabetes, fasting blood glucose and HbA1c. While duration of diabetes and serum IL-6 levels had an independent effect on DR development, zonulin had no effect.

Conclusions
Serum zonulin levels cannot be used as a biomarker for the progression of the diabetic retinopathy complication.
Ayahuasca-Tourismus in Peru: Motivationen und subjektive Bedeutungen bei Teilnehmern von Ayahuasca-Retreats im oberen Amazonasgebiet
Authors: Wolff Tom John 
Published: May 2021

ZusammenfassungAyahuasca ist ein stark psychoaktiver Trank des Amazonas-Regenwaldes, der zu einem florierenden Tourismus aus den industrialisierten Ländern ins ländliche Peru geführt hat. In einer teilnehmenden Beobachtung und qualitativen Befragung von Teilnehmern von traditionalisierten Ayahuasca-Seminaren im Regenwald werden Motive und subjektive Bedeutungen mittels qualitativer Inhaltsanalyse herausgearbeitet und in Beziehung zum sogenannten Pilgertourismus gestellt.
Amelioration of Bauxite Residues by Sequential Slurry Carbonation
Authors: Kuntikana Ganaraj , Syed Sayeeda , Singh Devendra Narain , Pandit Sagar S. , Kapuri Nageswar 
Published: May 2021

AbstractThe safe handling, storage, disposal, and use of the bauxite residues (BRs) has become a bug bear to alumina refineries not only because of the enormous quantity that gets generated but also because of its characteristics, namely, extremely high alkalinity and sodicity. One of the ways to negotiate with this situation would be to “neutralize the BRs,” a hypothesis that would transform them into a nonhazardous (chemically less or partially inert) material that could be used as a man-made resource for its bulk utilization in various infrastructure development and agronomical projects. In order to demonstrate the feasibility of this hypothesis, BRs from an alumina refinery of India were collected in their slurry form and neutralized by resorting to sequential slurry carbonation (SSC) technique. The SSC was achieved by employing (1) gaseous phase carbon dioxide, CO2, and (2) synthetic flue gas, which has a composition like that of stack gases produced from the industries. The study observed a sharp decline in pH of the BRs slurry in the initial phase of treatment, which lasted for 120 min, and the formation of neutralized BRs, designated as NBRs. The exposure, when continued beyond 120 min to 1,440 min, yielded NBRs that exhibit almost constant pH. The exposure of NBRs to the atmosphere resulted in a pH rebound with time.
Information Systems Outcomes based Assessment at Jouf University for ABET Accreditation
Authors: Et al. A. A. Abd El-Aziz 
Published: May 2021

The Accreditation Board for Engineering and Technology (ABET) Criteria for Computing Accreditation Commission Programs are based upon knowledge, presentation skills, communication skills, team work and leadership skills that the students gain through the curriculum in a program. The student outcomes (SOs) are the procured skills and knowledge which the student accomplishes through the curriculum. Each program needs to have its own SOs and to evaluate it as per defined assessment cycle, just as to accomplish program educational objectives (PEOs). The continuous improvement plan depended on assessment and evaluation of the program SOs and PEOs. In this paper, an advancement cycle for continuous improvement, for Information systems (IS) program at College of Computer and Information Sciences (CIS), Jouf University, Sakaka, Aljouf, Saudi Arabia, to accomplish the accreditation is discussed. The proposed cycle is appropriate to get the accreditation for bachelor program in information systems discipline and to fulfill the ABET criteria. In result, we will show how the SOs and PEOs were surveyed and assessed through curriculum accordingly. Based on these processes, ABET team has visited CIS college, which had accomplished extraordinary achievement and all of the programs have completely accredited on August 2018 and the next visit to the computing and engineering programs will be on 2026.
Resource Aware Gaussian Regressive Jarvis Patrick Clustering for Reliable Data Transmission in E-Health using WSN-IoT
Authors: Et al. M. Suguna 
Published: May 2021

Wireless sensor network (WSN) includes numerous sensor nodes (SN) integrated with Internet of Things (IoT) play a crucial role in numerous applications. IoT links physical devices as sensor and forms whole network for sharing information. The IoT has been used in different domains. In this scenario, patients utilize wearable medical sensors to monitor medical parameters. This medical sensor is equipped with batteries and has limited energy. Therefore, the network lifetime enhancement is a major challenging issue. To prolong network lifetime, novel technique called Resource-efficient Gaussian process regressive Jarvis Patrick clustering (REGPRJPC) is introduced. At first, the IoT devices are used in SN for sensing and collecting the patient data. After data collection process, SN is grouped into diverse clusters using Jarvis Patrick clustering technique. Jarvis Patrick clustering is graph-based clustering to partition SN with help of Gaussian process regression function. The regression function analyzes the SN and performs the clustering process based on the estimated energy and bandwidth. After clustering process, cluster head (CH) is selected to enhance data transmission and minimizes delay. Source node transmits gathered data to their CH. Then CH finds nearest CH using time of flight method. Followed by, data transmission is performed from source to sink node via the cluster head. In this way, resource-efficient data transmission is performed in WSN. Numerical analysis indicates that the REGPRJPC technique efficiently improves the reliable patient data packet delivery and minimizes the loss rate, delay.
Principal Component Analysis and Stability of Genotypes in French Bean (Phaseolus vulgaris L.)
Authors: Reddy B. Rajasekhar , Pandey Maneesh , Singh J. , Singh P.M. , Rai N. 
Published: May 2021

Background: Principal component analysis and Finlay-Wilkinson stability analysis were carried out at research farm of ICAR-Indian Institute of Vegetable Research, Varanasi to identify diverse french bean genotypes for green pod yield and suitable genotypes for stable yield and yield related parameters. Methods: All the 24 genotypes were laid out in randomized block design with two replications during winter, 2017 and 2018. Principal component analysis and stability analysis was done to identify the diverse and stable genotypes. Result: Eight principal components were observed and the maximum variability was concentrated in the first three principal components PC1, PC2 and PC3 which contributed to 68.61% variance. Cluster analysis from principal component scores formed three clusters with a maximum of seventeen genotypes in cluster I followed by six genotypes in cluster II and one genotype in cluster III. High heritability was observed for 10 pod weight, number of pods per cluster and number of seeds per pod and moderate heritability was observed for yield per plant. Finlay-Wilkinson stability analysis identified the stable genotypes viz., FMGCV 1378, FMGCV 0958, Arka Suvidha, Valentino, Banoa and VRFBB-14-2 for green pod yield per plant, Cartagenta for pod length (cm) and Paulista, Slender Pack, Arka Suvidha, Valentino, FMGCV 0958, Banoa, FORC 6V 1136, VRFBB-14-1, VRFBB-14-2 for number of pods per plant.