bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Surface Subsidence Measured by Airborne and Satellite InSAR Over Permafrost Areas Near Yellowknife Canada
Authors: Xu Xingyu , Liu Lin , Schaefer Kevin , Michaelides Roger 
Published: May 2021

AbstractIn addition to spaceborne Interferometric Synthetic Aperture Radar (InSAR), airborne data such as those obtained by the Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) have also been utilized to measure surface subsidence in permafrost areas in recent years. Motivated by the integration of multiplatform InSAR data, we generated two UAVSAR interferograms and one Advanced Land Observing Satellite (ALOS)‐2 L‐band interferogram over a permafrost area near Yellowknife, Canada, then compared the surface subsidence in the thaw seasons of 2017. The correlation coefficient and the root mean square error (RMSE) of subsidence difference are calculated to compare the airborne and spaceborne InSAR measurements. The results demonstrate that the two UAVSAR measurements are self‐consistent, with the correlation coefficient between independent airborne measurements ∼0.7. While the RMSE of the difference between surface subsidence measured by UAVSAR and ALOS2 is ∼2.0 cm, and the correlation coefficients are less than 0.41, that is, a noticeable deviation exists between the UAVSAR and ALOS2 results possibly due to different spatial resolution and the calibration processing of airborne and spaceborne InSAR data. In addition, both UAVSAR and ALOS2 interferograms show larger surface subsidence within taiga needleleaf forest regions than in regions of other biome types (including needleleaf forest, shrubland, and grassland). The results demonstrate that a scheme for the elimination of systematic differences needs to be developed before merging multisource InSAR results. This intercomparison will provide valuable insights for narrowing the gap between radar‐based measurements and planning the integration of airborne and satellite InSAR measurements in permafrost environments.
Uplift and Exposure of Serpentinized Massifs: Modeling Differential Serpentinite Diapirism and Exhumation of the Troodos Mantle Sequence, Cyprus
Authors: Evans Aled D. , Teagle Damon A. H. , Craw Dave , Henstock Timothy J. , Falcon‐Suarez Ismael Himar 
Published: May 2021

AbstractSerpentinized mantle peridotites form prominent mountains, including the highest elevations of the Troodos ophiolite in Cyprus (Mount Olympus, 1,952 m), but to date, only qualitative mechanisms have been proposed to explain the uplift of mantle rocks to high altitudes. Serpentinization reactions between mantle rocks and water result in profound changes to the rheology and physical properties of peridotites including significant density reduction (∼900 kg/m3). Field observations, density measurements, and isostatic uplift and erosional modeling provide new constraints on the contribution of serpentinization to the uplift of the Troodos Mantle Sequence. Different serpentinization styles have resulted in two distinct serpentinite domains with contrasting densities. Our modeling shows that the Troodos Mountains can form within the geologically constrained uplift time frame (∼5.5 Myr) exclusively through partial serpentinization reactions. We interpret the serpentinite domains as two nested diapirs that formed due to different extents of serpentinization and density reduction. Differential uplift and exhumation have decoupled the two serpentinite diapirs from the originally overlying ocean crustal rocks. Once at high altitudes the incursion of meteoric water reinforced coupled deformation‐alteration‐recrystallization processes in the shallow subsurface producing a localized low density completely serpentinized diapir. A second decoupling between the contrasting serpentinite diapirs results in localized differential uplift and exhumation, extruding deep materials to the east of Mount Olympus. Application of our modeling to other serpentinite massifs (e.g., St. Peter and St. Paul Rocks, New Idria, California) highlights the contribution of isostasy to the uplift of serpentinized massifs.
A Summary of National Oceanic and Atmospheric Administration Space Weather Prediction Center Proton Event Forecast Performance and Skill
Authors: Bain H. M. , Steenburgh R. A. , Onsager T. G. , Stitely E. M. 
Published: May 2021

AbstractThe effects of solar radiation storms at Earth are felt across a number of technology‐based industries. Energetic particles present during these storms impact electrical components on spacecraft, disrupt high frequency radio communications, and pose a radiation risk for passengers and crew on polar flight routes, as well as for astronauts. An essential aspect of space weather forecasting is therefore to predict the occurrence and properties of a solar proton event before it occurs. In this study, we review radiation storm products issued by the National Oceanic and Atmospheric Administration's Space Weather Prediction Center (SWPC) during Solar Cycles 23 and 24. These include three‐day probabilistic proton event forecasts and short‐term Warning and Alert hazard products. We present performance metrics and forecast skill scores for SWPC probabilistic forecasts and Warning products, which can be used as a benchmark for assessing the performance of radiation storm forecast models.
Characterization of the Candidate Landing Region for Tianwen‐1—China's First Mission to Mars
Authors: Wu Bo , Dong Jie , Wang Yiran , Li Zhaojin , Chen Zeyu , Liu Wai Chung , Zhu Jiaming , Chen Long , Li Yuan , Rao Wei 
Published: May 2021

AbstractThis paper presents our efforts to characterize the candidate landing region (109°–133°E, 23°–30°N) for Tianwen‐1, China's first mission to Mars, in terms of engineering safety and scientific significance. Topographic analysis reveals that the region has a low elevation around −4,230 m, and 98% of the region have slopes smaller than 8°. The geomorphological mapping and analysis show that the region has an average crater density of about 28 craters (≥200 m in diameter) per 100 square kilometers, with several clusters of high crater densities distributed around the center of the region. There are also pitted cones distributed mainly in the southern part of the region, with a density of approximately 6.6 cones per 100 square kilometers in specific local areas. The region has rock abundances ranging from 1% to 23%, with local clusters of low and high rock abundances. The region comprises four main geological units, including a lowland unit formed in the Late Hesperian and a volcanic unit formed in the Amazonian and Hesperian period. Their specific surface ages are estimated through the analysis of crater size‐frequency distribution. Combining the engineering constraints on surface slopes, crater density, cone density, and rock abundance, a hazard map of the candidate landing region is generated for landing site evaluation and safety assessment. Based on the results, we further discuss the potential scientific outcomes from the exploration in this region. The findings will be helpful for the mission planning and maximization of the scientific return from Tianwen‐1, and complement existing Martian scientific research.
Re‐Reconnection Processes of Magnetopause Flux Ropes: Three‐Dimensional Global Hybrid Simulations
Authors: Guo Jin , Lu San , Lu Quanming , Lin Yu , Wang Xueyi , Huang Kai , Wang Rongsheng , Wang Shui 
Published: May 2021

AbstractMagnetopause flux ropes (FRs) play a crucial role in the transport of energy and plasma from the solar wind to the Earth’s magnetosphere. Once formed by multiple X‐line reconnection, the FRs move poleward, during which they can coalesce with each other through a re‐reconnection process. The poleward moving FRs eventually coalesce into the cusp regions, through another re‐reconnection process. In this paper, using three‐dimensional (3‐D) global hybrid simulations, we study the two re‐reconnection processes of magnetopause FRs by examining the topological changes of magnetic field lines. These re‐reconnection processes are essentially 3‐D. Two FRs coalesce with each other and form two new FRs (instead of one new FR in the two‐dimensional regime). When FRs move close to the cusp region, their field lines can reconnect with the cusp field lines so that the FRs can break into two shorter ones. The two re‐reconnection processes increase the plasma energy and the magnetic flux connected to the Earth, which favors particle and energy transport toward the Earth’s magnetosphere.
On the Sources and Sizes of Uncertainty in Predicting the Arrival Time of Interplanetary Coronal Mass Ejections Using Global MHD Models
Authors: Riley Pete , Ben‐Nun Michal 
Published: May 2021

AbstractAccurate predictions of the properties of interplanetary coronal mass ejection (ICME)‐driven disturbances are a key objective for space weather forecasts. The ICME's time of arrival (ToA) at Earth is an important parameter, and one that is amenable to a variety of modeling approaches. Previous studies suggest that the best models can predict the arrival time to within an absolute uncertainty of 10–15 h. Here, we investigate the main sources of uncertainty in predicting a CME's ToA at Earth. These can be broken into two main categories: (a) the initial properties of the ejecta, including its speed, mass, and direction of propagation and (b) the properties of the ambient solar wind into which it propagates. To estimate the relative contribution to ToA uncertainties, we construct a set of numerical experiments of cone‐model CMEs, where we vary the initial speed, mass, and direction at the inner radial boundary. Additionally, we build an ensemble of 12 ambient solar wind solutions using realizations from the ADAPT model. We find that each component in the chain contributes between ±2.5 and ±7 h of uncertainty to the estimate of the CME's ToA. Importantly, different realizations of the synoptic produce the largest uncertainties. This suggests that estimates of ToA will continue to be plagued with intrinsic uncertainties of ±10 h until tighter constraints can be found for these boundary conditions. Our results suggest that there are clear benefits to focused investigations aimed at reducing the uncertainties in CME speed, mass, direction, and input boundary magnetic fields.
Coherent interaction of atoms with a beam of light confined in a light cage
Authors: Davidson-Marquis Flavie , Gargiulo Julian , Gómez-López Esteban , Jang Bumjoon , Kroh Tim , Müller Chris , Ziegler Mario , Maier Stefan A. , Kübler Harald , Schmidt Markus A. , Benson Oliver 
Published: May 2021

AbstractControlling coherent interaction between optical fields and quantum systems in scalable, integrated platforms is essential for quantum technologies. Miniaturised, warm alkali-vapour cells integrated with on-chip photonic devices represent an attractive system, in particular for delay or storage of a single-photon quantum state. Hollow-core fibres or planar waveguides are widely used to confine light over long distances enhancing light-matter interaction in atomic-vapour cells. However, they suffer from inefficient filling times, enhanced dephasing for atoms near the surfaces, and limited light-matter overlap. We report here on the observation of modified electromagnetically induced transparency for a non-diffractive beam of light in an on-chip, laterally-accessible hollow-core light cage. Atomic layer deposition of an alumina nanofilm onto the light-cage structure was utilised to precisely tune the high-transmission spectral region of the light-cage mode to the operation wavelength of the atomic transition, while additionally protecting the polymer against the corrosive alkali vapour. The experiments show strong, coherent light-matter coupling over lengths substantially exceeding the Rayleigh range. Additionally, the stable non-degrading performance and extreme versatility of the light cage provide an excellent basis for a manifold of quantum-storage and quantum-nonlinear applications, highlighting it as a compelling candidate for all-on-chip, integrable, low-cost, vapour-based photon delay.
Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models
Authors: Di Martile Marta , Garzoli Stefania , Sabatino Manuela , Valentini Elisabetta , D’Aguanno Simona , Ragno Rino , Del Bufalo Donatella 
Published: May 2021

AbstractEssential oils (EOs) have been recently emerging for their promising biological activities in preventing tumorigenesis or progression of different tumor histotypes, including melanoma. In this study, we investigated the antitumor activity of a panel of EOs in different tumor models. The ability of Melaleuca alternifolia (tea tree oil) and its main component, terpinen-4-ol, to sensitize the target therapy currently used for melanoma treatment was also assessed. Our results demonstrated that EOs differently affect the viability of human cancer cells and led us to select six EOs effective in melanoma and lung cancer cells, without toxic effects in human fibroblasts. When combined with dabrafenib and/or trametinib, Melaleuca alternifolia synergistically reduced the viability of melanoma cells by activating apoptosis. Through machine learning classification modeling, α-terpineol, tepinolene, and terpinen-4-ol, three components of Melaleuca alternifolia, were identified as the most likely relevant components responsible for the EO’s antitumor effect. Among them, terpinen-4-ol was recognized as the Melaleuca alternifolia component responsible for its antitumor and proapoptotic activity. Overall, our study holds promise for further analysis of EOs as new anticancer agents and supports the rationale for their use to improve target therapy response in melanoma.
Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32
Authors: Lehmkuhl Peter , Gentz Magdalena , Garcia de Otezya Andres Caballero , Grimbacher Bodo , Schulze-Koops Hendrik , Skapenko Alla 
Published: May 2021

AbstractImmune dysregulation diseases are characterized by heterogeneous clinical manifestations and may have severe disease courses. The identification of the genetic causes of these diseases therefore has critical clinical implications. We performed whole-exome sequencing of patients with immune dysregulation disorders and identified two patients with previously undescribed mutations in LRRC32, which encodes glycoprotein A repetitions predominant (GARP). These patients were characterized by markedly reduced numbers and frequencies of regulatory T cells (Tregs). Tregs with mutated LRRC32 exhibited strongly diminished cell-surface GARP expression and reduced suppressor function. In a model of conditional Garp deficiency in mice, we confirmed increased susceptibility to inflammatory diseases once GARP expression on Tregs was decreased. Garp deficiency led to an unstable Treg phenotype due to diminished Foxp3 protein acetylation and stability. Our study reinforces the understanding of the immunological mechanisms of immune dysregulation and expands the knowledge on the immunological function of GARP as an important regulator of Treg stability.
Evidence accumulation relates to perceptual consciousness and monitoring
Authors: Pereira Michael , Megevand Pierre , Tan Mi Xue , Chang Wenwen , Wang Shuo , Rezai Ali , Seeck Margitta , Corniola Marco , Momjian Shahan , Bernasconi Fosco , Blanke Olaf , Faivre Nathan 
Published: May 2021

AbstractA fundamental scientific question concerns the neural basis of perceptual consciousness and perceptual monitoring resulting from the processing of sensory events. Although recent studies identified neurons reflecting stimulus visibility, their functional role remains unknown. Here, we show that perceptual consciousness and monitoring involve evidence accumulation. We recorded single-neuron activity in a participant with a microelectrode in the posterior parietal cortex, while they detected vibrotactile stimuli around detection threshold and provided confidence estimates. We find that detected stimuli elicited neuronal responses resembling evidence accumulation during decision-making, irrespective of motor confounds or task demands. We generalize these findings in healthy volunteers using electroencephalography. Behavioral and neural responses are reproduced with a computational model considering a stimulus as detected if accumulated evidence reaches a bound, and confidence as the distance between maximal evidence and that bound. We conclude that gradual changes in neuronal dynamics during evidence accumulation relates to perceptual consciousness and perceptual monitoring in humans.
Investment incentive reduced by climate damages can be restored by optimal policy
Authors: Willner Sven N. , Glanemann Nicole , Levermann Anders 
Published: May 2021

AbstractIncreasing greenhouse gas emissions are likely to impact not only natural systems but economies worldwide. If these impacts alter future economic development, the financial losses will be significantly higher than the mere direct damages. So far, potentially aggravating investment responses were considered negligible. Here we consistently incorporate an empirically derived temperature-growth relation into the simple integrated assessment model DICE. In this framework we show that, if in the next eight decades varying temperatures impact economic growth as has been observed in the past three decades, income is reduced by ~ 20% compared to an economy unaffected by climate change. Hereof ~ 40% are losses due to growth effects of which ~ 50% result from reduced incentive to invest. This additional income loss arises from a reduced incentive for future investment in anticipation of a reduced return and not from an explicit climate protection policy. Under economically optimal climate-change mitigation, however, optimal investment would only be reduced marginally as mitigation efforts keep returns high.
Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice
Authors: Sincennes Marie-Claude , Brun Caroline E. , Lin Alexander Y. T. , Rosembert Tabitha , Datzkiw David , Saber John , Ming Hong , Kawabe Yoh-ichi , Rudnicki Michael A. 
Published: May 2021

AbstractMuscle stem cell function has been suggested to be regulated by Acetyl-CoA and NAD+ availability, but the mechanisms remain unclear. Here we report the identification of two acetylation sites on PAX7 that positively regulate its transcriptional activity. Lack of PAX7 acetylation reduces DNA binding, specifically to the homeobox motif. The acetyltransferase MYST1 stimulated by Acetyl-CoA, and the deacetylase SIRT2 stimulated by NAD +, are identified as direct regulators of PAX7 acetylation and asymmetric division in muscle stem cells. Abolishing PAX7 acetylation in mice using CRISPR/Cas9 mutagenesis leads to an expansion of the satellite stem cell pool, reduced numbers of asymmetric stem cell divisions, and increased numbers of oxidative IIA myofibers. Gene expression analysis confirms that lack of PAX7 acetylation preferentially affects the expression of target genes regulated by homeodomain binding motifs. Therefore, PAX7 acetylation status regulates muscle stem cell function and differentiation potential to facilitate metabolic adaptation of muscle tissue.
Diverse electronic and magnetic properties of CrS2 enabling strain-controlled 2D lateral heterostructure spintronic devices
Authors: Chen Kaiyun , Deng Junkai , Yan Yuan , Shi Qian , Chang Tieyan , Ding Xiangdong , Sun Jun , Yang Sen , Liu Jefferson Zhe 
Published: May 2021

AbstractLateral heterostructures of two-dimensional (2D) materials, integrating different phases or materials into a single piece of nanosheet, have attracted intensive research interests for electronic devices. Extending the 2D lateral heterostructures to spintronics demands more diverse electromagnetic properties of 2D materials. In this paper, using density functional theory calculations, we survey all IV, V, and VI group transition metal dichalcogenides (TMDs) and discover that CrS2 has the most diverse electronic and magnetic properties: antiferromagnetic (AFM) metallic 1T phase, non-magnetic (NM) semiconductor 2H phase, and ferromagnetic (FM) semiconductor 1T′ phase with a Curie temperature of ~1000 K. Interestingly, we find that a tensile or compressive strain can turn the 1T′ phase into a spin-up or spin-down half-metal. Such strain tunability can be attributed to the lattice deformation under tensile/compressive strain that selectively promotes the spin-up/spin-down VBM (valence band bottom) orbital interactions. The diverse electromagnetic properties and the strain tunability enable strain-controlled spintronic devices using a single piece of CrS2 nanosheet with improved energy efficiency. As a demo, a prototypical design of the spin-valve logic device is presented. It offers a promising solution to address the challenge of high energy consumption in miniaturized spintronic devices.
Crystal-chirality-dependent control of magnetic domains in a time-reversal-broken antiferromagnet
Authors: Kimura Kenta , Kato Yasuyuki , Kimura Shojiro , Motome Yukitoshi , Kimura Tsuyoshi 
Published: May 2021

AbstractChiral-lattice magnets can exhibit a variety of physical phenomena when time-reversal symmetry is broken by their magnetism. For example, nonreciprocal responses of (quasi)particles have been widely observed in chiral-lattice magnets with macroscopic magnetization. Meanwhile, time-reversal symmetry can also be broken in antiferromagnets without magnetization. Here we report an unconventional chirality-magnetism coupling in a chiral-lattice antiferromagnet Pb(TiO)Cu4(PO4)4 whose time-reversal symmetry is broken by an ordering of magnetic quadrupoles. Our experiments demonstrate that a sign of magnetic quadrupoles is controllable by a magnetic field only, which is generally impossible in consideration of the symmetry of magnetic quadrupoles. Furthermore, we find that the sign of magnetic quadrupoles stabilized by applying a magnetic field is reversed by a switching of the chirality. Our theoretical calculations and phenomenological approach reveal that this unusual coupling between the chirality and magnetic quadrupoles is mediated by the previously-unrecognized magnetic octupoles that emerge due to the chirality.
Prostate cancer risk variants of the HOXB genetic locus
Authors: Dupont William D. , Breyer Joan P. , Johnson Spenser H. , Plummer W. Dale , Smith Jeffrey R. 
Published: May 2021

AbstractThe G84E germline mutation of HOXB13 predisposes to prostate cancer and is clinically tested for familial cancer care. We investigated the HOXB locus to define a potentially broader contribution to prostate cancer heritability. We sought HOXB locus germline variants altering prostate cancer risk in three European-ancestry case–control study populations (combined 7812 cases and 5047 controls): the International Consortium for Prostate Cancer Genetics Study; the Nashville Familial Prostate Cancer Study; and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Multiple rare genetic variants had concordant and strong risk effects in these study populations and exceeded genome-wide significance. Independent risk signals were best detected by sentinel variants rs559612720 within SKAP1 (OR = 8.1, P = 2E−9) and rs138213197 (G84E) within HOXB13 (OR = 5.6, P = 2E−11), separated by 567 kb. Half of carriers inherited both risk alleles, while others inherited either alone. Under mutual adjustment, the variants separately carried 3.6- and 3.1-fold risk, respectively, while joint inheritance carried 11.3-fold risk. These risks were further accentuated among men meeting criteria for hereditary prostate cancer, and further still for those with early-onset or aggressive disease. Among hereditary prostate cancer cases diagnosed under age 60 and with aggressive disease, joint inheritance carried a risk of OR = 27.7 relative to controls, P = 2E−8. The HOXB sentinel variant pair more fully captured genetic risk for prostate cancer within the study populations than either variant alone.