bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtue, Body, Mind and Spirit in the Shijing: New Perspectives on Pre-Warring States Conceptions of Personhood and Virtue
Authors: Raphals Lisa 
Published: February 2021

Abstract
This paper addresses the location of virtue within a virtuous person. It examines the relations of body (shen 身, ti 體, xing 形, gong 躬), mind (xin 心) and spirit (shen 神) in the Shijing 詩經, which describes virtue (de 德) in terms of the bodies and minds of virtuous agents. I argue that virtue is attributed to outward behavior, rather than inner state, and that that behavior is described via the performance of the shen or gong body.
Egypt’s COVID-19 Response through a Gender Lens
Authors: Salem Nora 
Published: February 2021

Abstract
Across every sphere of life—health, economy, social security, livelihood and education—the impacts of COVID-19 are exacerbated for women due to persisting gender inequalities. Women are not only more likely to contract COVID-19, but also lockdowns have affected women’s economic and social security disproportionately due to increased unpaid care work at home, women’s high representation in vulnerable employment or employment in the informal labour sector. Upon the declaration of COVID-19 as a pandemic by the World Health Organization (WHO) on 11 March 2020, the Egyptian Government adopted a variety of public health measures to contain the widespread of the virus on 14 March 2020, accompanied by certain mitigation measures to reduce disproportionate impacts on women. Against this backdrop, this article examines the existence and scope of an international obligation to adopt mitigation measures to reduce disproportionate impacts on women and analyzes Egypt’s COVID-19 response against such obligation.
Pursuing Accountability and Protection for the Uighur and Muslim Minorities in China
Authors: Jacob Cecilia , Gallagher Adrian , Hunt Charles T. 
Published: February 2021

Abstract
This short article introduces the forum on the Uighur population in China and R2P. It provides context to demonstrate why it is important to analyse the current situation in Xinjiang Uighur Autonomous Region of China through an R2P lens and states the objectives of the forum. It then provides a brief summary of the contributions in the forum that take into account the domestic context, legal arguments and analysis of the international political context in which R2P is operationalised.
Writing-Mediated Interaction Face-to-Face: Sinitic Brushtalk (漢文筆談) as an Age-Old Lingua-Cultural Practice in Premodern East Asian Cross-Border Communication
Authors: Li David C. S. 
Published: February 2021

Abstract
In Western societies, speaking is construed as an interactive social activity while writing is widely perceived as a solo or private endeavor. Such a functional dichotomy did not apply to the “Sinographic Cosmopolis” in premodern East Asia, however. Based on selected documented examples of writing-mediated cross-border communication spanning over a thousand years from the Sui dynasty to the late Ming dynasty, this paper demonstrates that Hanzi 漢字, a morphographic, non-phonographic script, was commonly used by literati of classical Chinese or Literary Sinitic to engage in “silent conversation” as a substitute for speech. Except for a “drifting” record co-constructed by Korean maritime officials and Chinese “boat people,” all the other examples featured Chinese–Japanese interaction. While synchronous cross-border communication in written Chinese has been reported in scholarly works in East Asian studies (published more commonly in East Asian languages than in English or other Western languages), to our knowledge no attempt has been made to examine such writing-mediated interaction from a linguistic or discourse-pragmatic point of view. Writing-mediated interaction enacted through Sinitic brushtalk (漢文筆談) is compatible with transactional and interactional language functions as in speech. In premodern and early modern East Asia, it was most commonly conducted using brush, ink, and paper, but it could also take place using a pointed object and a flat surface covered with a fluid substance like sand, finger-drawing using water or tea on a table, and so forth. Such an interactional pattern appears to be unparalleled in other regional lingua francas written with a phonographic script such as Latin and Arabic. To facilitate research into the extent to which this interactional pattern is script-specific to morphographic sinograms, a “morphographic hypothesis” is proposed. The theoretical significance of writing-mediated interaction as a third or even fourth known modality of synchronous communication—after speech and (tactile) sign language—will be briefly discussed.
Effect of Metatarsus Adductus on Hallux Valgus Treated With Proximal Reverse Chevron Metatarsal Osteotomy
Authors: Choi Seung-Myung , Lee Jong-Soo , Lim Jung-Won , Im Je-Min , Kho Duk-Hwan , Jung Hong-Geun 
Published: February 2021

Background: This study aimed to compare clinical and radiographic outcomes and recurrence rates after reverse proximal chevron metatarsal osteotomy (PCMO) for patients with hallux valgus (HV) with or without metatarsus adductus (MA). We hypothesized that patients with MA would have poorer outcomes and a higher radiographic recurrence rate than those without MA. Methods: This retrospective single-surgeon series comprised 144 patients (173 feet) with moderate to severe HV, treated with PCMO and Akin osteotomy without lesser metatarsal procedures, who were grouped according to the presence (MA group) or absence of MA (non-MA group). Clinical assessment included the American Orthopaedic Foot & Ankle Society (AOFAS) score, pain visual analog scale (VAS), and patient satisfaction rating. Radiographic assessments included metatarsus adductus angle (MAA), HV angle (HVA), and intermetatarsal angle (IMA). Results: The prevalence of the MA was 24.2%. The mean MAA was 23.1 ± 3.3 degrees in the MA group. There were no differences in the mean AOFAS score and pain VAS score at the final follow-up between the 2 groups (all P > .05). The patient satisfaction rate was 73.8% in the MA group vs 90.1% in the non-MA group ( P = .017). The mean postoperative HVA and IMA significantly improved at the final follow-up in both groups, respectively (all P < .001). Preoperative and postoperative HVA were larger in the MA group vs non-MA group. However, no significant difference was found in the improvement of HVA and IMA after surgery between the 2 groups (all P > .05). The recurrence rate was 28.6% in the MA group and 6.1% in the non-MA group ( P < .001). Conclusion: HV patients associated with the MA had a higher degree of preoperative HV, lower correction of the HVA, higher radiographic recurrence rate, and poorer patient satisfaction than those without MA post-PCMO without lesser metatarsal procedures. Therefore, a more extensive HV correction procedure or the addition of a lesser metatarsal realignment procedure may need to be considered. Level of Evidence: Level III, retrospective comparative series.
Prognostic restaging after treatment initiation in patients with AL amyloidosis
Authors: Abdallah Nadine , Dispenzieri Angela , Muchtar Eli , Buadi Francis K. , Kapoor Prashant , Lacy Martha Q. , Hwa Yi L. , Fonder Amie , Hobbs Miriam A. , Hayman Suzanne R. , Leung Nelson , Dingli David , Lust John A. , Go Ronald S. , Lin Yi , Gonsalves Wilson I. , Kourelis Taxiarchis , Warsame Rahma , Kyle Robert A. , Rajkumar S. Vincent , Gertz Morie A. , Kumar Shaji K. 
Published: February 2021

Abstract
The utility of systemic light chain (AL) amyloidosis staging systems has been validated for newly diagnosed patients, but their role in restaging after treatment has not been explored. We designed this study to evaluate whether the currently used systems are of prognostic value at 3 and 6 months of starting first-line treatment, and whether stage migration from diagnosis impacts survival. This is a retrospective study including Mayo Clinic patients with AL amyloidosis diagnosed between 1 January 2006 and 30 June 2019; 536 and 204 patients had restaging data for at least 1 system at 3 and 6 months, respectively. Using modified Mayo 2004 staging at 3 months, median overall survival (OSs) were 11.8, 10.8, 4.6, and 1.1 years for stage I, II, IIIa, and IIIb, respectively. Using Mayo 2012, median OSs were 11.8, 9.0, 5.2, and 0.8 years for stage I, II, III, and IV, respectively. Using modified Mayo 2004 staging at 6 months, median OSs were not reached (NR), NR, 5.4, and 0.9 years for stage I, II, IIIa, and IIIb, respectively. Using Mayo 2012, OSs were NR, NR, 4.6, and 0.9 years for stage I, II, III, and IV, respectively. Worsening stage at 3 or 6 months was associated with worse survival than retaining baseline stage. In conclusion, the current staging systems can be used for restaging at 3 and 6 months from treatment initiation. Migration to higher stage predicts poor prognosis.
Grouping of genomic markers in populations with family structure
Authors: Wittenburg Dörte , Doschoris Michael , Klosa Jan 
Published: February 2021

Abstract
Background
Linkage and linkage disequilibrium (LD) between genome regions cause dependencies among genomic markers. Due to family stratification in populations with non-random mating in livestock or crop, the standard measures of population LD such as $$r^2$$

r
2

may be biased. Grouping of markers according to their interdependence needs to account for the actual population structure in order to allow proper inference in genome-based evaluations.

Results
Given a matrix reflecting the strength of association between markers, groups are built successively using a greedy algorithm; largest groups are built at first. As an option, a representative marker is selected for each group. We provide an implementation of the grouping approach as a new function to the R package . This package enables the calculation of the theoretical covariance between biallelic markers for half- or full-sib families and the derivation of representative markers. In case studies, we have shown that the number of groups comprising dependent markers was smaller and representative SNPs were spread more uniformly over the investigated chromosome region when the family stratification was respected compared to a population-LD approach. In a simulation study, we observed that sensitivity and specificity of a genome-based association study improved if selection of representative markers took family structure into account.

Conclusions
Chromosome segments which frequently recombine in the underlying population can be identified from the matrix of pairwise dependence between markers. Representative markers can be exploited, for instance, for dimension reduction prior to a genome-based association study or the grouping structure itself can be employed in a grouped penalization approach.
Activation of short-chain ketones and isopropanol in sulfate-reducing bacteria
Authors: Frey Jasmin , Kaßner Sophie , Spiteller Dieter , Mergelsberg Mario , Boll Matthias , Schleheck David , Schink Bernhard 
Published: February 2021

Abstract
Background
Degradation of acetone by aerobic and nitrate-reducing bacteria can proceed via carboxylation to acetoacetate and subsequent thiolytic cleavage to two acetyl residues. A different strategy was identified in the sulfate-reducing bacterium Desulfococcus biacutus that involves formylation of acetone to 2-hydroxyisobutyryl-CoA.

Results
Utilization of short-chain ketones (acetone, butanone, 2-pentanone and 3-pentanone) and isopropanol by the sulfate reducer Desulfosarcina cetonica was investigated by differential proteome analyses and enzyme assays. Two-dimensional protein gel electrophoresis indicated that D. cetonica during growth with acetone expresses enzymes homologous to those described for Desulfococcus biacutus: a thiamine diphosphate (TDP)-requiring enzyme, two subunits of a B12-dependent mutase, and a NAD+-dependent dehydrogenase. Total proteomics of cell-free extracts confirmed these results and identified several additional ketone-inducible proteins. Acetone is activated, most likely mediated by the TDP-dependent enzyme, to a branched-chain CoA-ester, 2-hydroxyisobutyryl-CoA. This compound is linearized to 3-hydroxybutyryl-CoA by a coenzyme B12-dependent mutase followed by oxidation to acetoacetyl-CoA by a dehydrogenase. Proteomic analysis of isopropanol- and butanone-grown cells revealed the expression of a set of enzymes identical to that expressed during growth with acetone. Enzyme assays with cell-free extract of isopropanol- and butanone-grown cells support a B12-dependent isomerization. After growth with 2-pentanone or 3-pentanone, similar protein patterns were observed in cell-free extracts as those found after growth with acetone.

Conclusions
According to these results, butanone and isopropanol, as well as the two pentanone isomers, are degraded by the same enzymes that are used also in acetone degradation. Our results indicate that the degradation of several short-chain ketones appears to be initiated by TDP-dependent formylation in sulfate-reducing bacteria.
Genome-wide association of rice response to blast fungus identifies loci for robust resistance under high nitrogen
Authors: Frontini Mathias , Boisnard Arnaud , Frouin Julien , Ouikene Malika , Morel Jean Benoit , Ballini Elsa 
Published: February 2021

Abstract
Background
Nitrogen fertilization is known to increase disease susceptibility, a phenomenon called Nitrogen-Induced Susceptibility (NIS). In rice, this phenomenon has been observed in infections with the blast fungus Magnaporthe oryzae. A previous classical genetic study revealed a locus (NIS1) that enhances susceptibility to rice blast under high nitrogen fertilization. In order to further address the underlying genetics of plasticity in susceptibility to rice blast after fertilization, we analyzed NIS under greenhouse-controlled conditions in a panel of 139 temperate japonica rice strains. A genome-wide association analysis was conducted to identify loci potentially involved in NIS by comparing susceptibility loci identified under high and low nitrogen conditions, an approach allowing for the identification of loci validated across different nitrogen environments. We also used a novel NIS Index to identify loci potentially contributing to plasticity in susceptibility under different nitrogen fertilization regimes.

Results
A global NIS effect was observed in the population, with the density of lesions increasing by 8%, on average, under high nitrogen fertilization. Three new QTL, other than NIS1, were identified. A rare allele of the RRobN1 locus on chromosome 6 provides robust resistance in high and low nitrogen environments. A frequent allele of the NIS2 locus, on chromosome 5, exacerbates blast susceptibility under the high nitrogen condition. Finally, an allele of NIS3, on chromosome 10, buffers the increase of susceptibility arising from nitrogen fertilization but increases global levels of susceptibility. This allele is almost fixed in temperate japonicas, as a probable consequence of genetic hitchhiking with a locus involved in cold stress adaptation.

Conclusions
Our results extend to an entire rice subspecies the initial finding that nitrogen increases rice blast susceptibility. We demonstrate the usefulness of estimating plasticity for the identification of novel loci involved in the response of rice to the blast fungus under different nitrogen regimes.
A framework for exploring non-response patterns over time in health surveys
Authors: Mölenberg Famke J. M. , de Vries Chris , Burdorf Alex , van Lenthe Frank J. 
Published: February 2021

Abstract
Background
Most health surveys have experienced a decline in response rates. A structured approach to evaluate whether a decreasing - and potentially more selective - response over time biased estimated trends in health behaviours is lacking. We developed a framework to explore the role of differential non-response over time. This framework was applied to a repeated cross-sectional survey in which the response rate gradually declined.

Methods
We used data from a survey conducted biannually between 1995 and 2017 in the city of Rotterdam, The Netherlands. Information on the sociodemographic determinants of age, sex, and ethnicity was available for respondents and non-respondents. The main outcome measures of prevalence of sport participation and watching TV were only available for respondents. The framework consisted of four steps: 1) investigating the sociodemographic determinants of responding to the survey and the difference in response over time between sociodemographic groups; 2) estimating variation in health behaviour over time; 3) comparing weighted and unweighted prevalence estimates of health behaviour over time; and 4) comparing associations between sociodemographic determinants and health behaviour over time.

Results
The overall response rate per survey declined from 47% in 1995 to 15% in 2017. The probability of responding was higher among older people, females, and those with a Western background. The response rate declined in all subgroups, and a faster decline was observed among younger persons and those with a non-Western ethnicity as compared to older persons and those with a Western ethnicity. Variation in health behaviours remained constant. Prevalence estimates and associations did not follow the changes in response over time. On the contrary, the difference in probability of participating in sport gradually decreased between males and females, while no differential change in the response rate was observed.

Conclusions
Providing insights on non-response patterns over time is essential to understand whether declines in response rates may have influenced estimated trends in health behaviours. The framework outlined in this study can be used for this purpose. In our example, in spite of a major decline in response rate, there was no evidence that the risk of non-response bias increased over time.
Chest wall pseudotumor: a case of non-tuberculous mycobacterial infection
Authors: Shishido Yutaka , Hamakawa Hiroshi , Minami Kazuhiro , Hara Shigeo , Takahashi Yutaka 
Published: February 2021

Abstract
Background
Non-tuberculous mycobacterial (NTM) infections are increasing worldwide, making them an international public health problem. Surgical management is often indicated for localized infectious disease; however, most surgeons are unaware of the potential risks of transmission during surgery.

Case presentation
An 88-year-old Asian female was referred to our hospital for a tumor in the right lateral thoracic region. One month prior, she had a feeling of fullness and complained of localized pain and warmth in the right lateral thoracic wall. Pain and warmth gradually resolved without intervention; however, the fullness was getting worse. Computed tomography (CT) scan showed a mass of approximately 65 × 30 mm with an osteolytic change, involving the right 8th rib. Based on the rapid growth rate and CT findings, we strongly suspected a malignant chest wall tumor, and en bloc tumor resection with the 8th rib was performed. When the specimen was cut, a large amount of viscous pus was drained and its culture showed growth of Mycobacterium avium. Microscopically, the non-caseating epithelioid cell granuloma extended into the rib, infiltrating the bone cortex. On follow-up 1 month after discharge, there were no signs of infection or other adverse events associated with the surgery.

Conclusions
Herein, we report about a patient with a mass diagnosed as an NTM abscess involving the rib cage, which was confused with a malignant tumor and eventually diagnosed following surgical excision. This report emphasizes the need to be aware of the possibility of NTM infection and take appropriate precautions if the patient has a rapidly growing mass in the chest wall.
An outbreak investigation of scrub typhus in Nepal: confirmation of local transmission
Authors: Dhimal Meghnath , Dumre Shyam Prakash , Sharma Guna Nidhi , Khanal Pratik , Ranabhat Kamal , Shah Lalan Prasad , Lal Bibek Kumar , Jha Runa , Upadhyaya Bishnu Prasad , Acharya Bhim , Shrestha Sanjaya Kumar , Davidson Silas A. , Charoensinphon Piyada , Karki Khem B. 
Published: February 2021

Abstract
Background
Scrub typhus is a largely ignored tropical disease and a leading cause of undifferentiated febrile illness in the areas of tsutsugamushi triangle caused by Orientia tsutsugamushi. It is frequently diagnosed in South Asian countries, although clear epidemiological information is not available from Nepal. After the 2015 earthquake in Nepal, a sudden upsurge in scrub typhus cases was reported. The objective of this study was to investigate epidemiology of scrub typhus and its causative agents in humans, animals, and chigger mites to understand the ongoing transmission ecology.

Methods
Scrub typhus cases with confirmed diagnosis throughout the country were included in the analysis. Studies were concentrated in the Chitwan district, the site of a major outbreak in 2016. Additional nation-wide data from 2015 to 2017 available from the government database included to analyse the disease distribution by geographical mapping.

Results
From 2015 to 2017, 1239 scrub typhus cases were confirmed with the largest outbreak occurring in 2016 with 831 (67.1%) cases. The case fatality rate was 5.7% in 2015 which declined to 1.1% in 2017. A nationwide outbreak of scrub typhus was declared as the cases were detected in 52 out of the 75 districts of Nepal. Seasonal trend was observed with a peak during August and September. In addition to the human cases, the presence of O. tsutsugamushi was also confirmed in animals (rodents) and chigger mites (Leptotrombidium imphalum) from the outbreak areas of southern Nepal.

Conclusion
The detection of O. tsutsugamushi in humans, animals, and chigger mites from outbreak locations and wide-spread reports of scrub typhus throughout the country consecutively for 3 years confirms the ongoing transmission of O. tsutsugamushi with a firmly established ecology in Nepal. The country’s health system needs to be strengthened for systematic surveillance, early outbreak detection, and immediate actions including treatment and preventive measures.