bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical‐radiological approach for the diagnosis of cleidocranial dysplasia in adults: A familial cases series
Authors: Segovia‐Fuentes Javier Ignacio , Egurrola‐Pedraza Jorge Armando , Castro‐Mendoza Edgar Junior , Cano‐Pérez Eder , Gómez‐Camargo Doris Esther , Malambo‐García Dacia Isabel 
Published: December 2021

AbstractCleidocranial dysplasia is a rare disease with an autosomal‐dominant inheritance that mainly affects the bones of the axial skeleton. In this report, we discuss the clinical and radiological signs of a case series comprising three sisters and the son of one of the sisters, all with suspected bone dysplasia.
Oxygen: Friend or foe in the COVID‐19 battle
Authors: Chudasama Kishan , Sangey Esmail 
Published: December 2021

AbstractHypoxia and hypoxemia are two different entities. Correcting hypoxemia without hypoxia tends to have disastrous effects and delays lung healing. In this study, we share a case of an elderly man with moderate COVID‐19 who never received any form of supplemental oxygen as compared to other patients with similar presentation.
ONE FORTY WEST – Hybrid‐Design‐Tower in Frankfurt
Authors: Einck Jürgen 
Published: December 2021

AbstractDas ONE FORTY WEST liegt im Senckenberg‐Quartier in Frankfurt am Main. Der außergewöhnliche, 41‐stöckige Design‐Tower wurde von CMA Architekten aus Frankfurt entworfen. Aufgrund seiner kombinierten Nutzung als Hotel im unteren Bereich und Wohnen in den Ebenen 24 bis 40, wird der Turm auch als „Hybrid‐Hochhaus“ bezeichnet. Die hochtransparente Fassade und die sich nach oben wie ein gewickeltes Band um den Tower legenden Balkone und Skylounges, ermöglichen den Bewohnern maximalen Komfort und beste Aussichten. Der gestalterisch außergewöhnliche und konstruktiv anspruchsvolle Entwurf der Architekten stellte das gesamte Planungsteam und die ausführenden Firmen, insbesondere hinsichtlich der Entwicklung und Umsetzung der Fassade, vor diverse planerische Herausforderungen. Das gebaute Ergebnis ist spektakulär und schon jetzt ein weiteres Wahrzeichen der Frankfurter Skyline.ONE FORTY WEST – Hybrid‐Design‐Tower in Frankfurt. The ONE FORTY WEST is located in the quarter of “Senckenberg Quartier” in Frankfurt (on the Main). The extraordinary 41‐story tower was designed by Frankfurt‐based architecture CMA Cyrus Moser Architekten. Due to its combined use as a hotel in the lower area and living on levels 24 to 40, the tower is also known as a “hybrid high‐rise building”. The highly transparent facade and a string of balconies and skylounges wrapping around the tower in an ascending motion guarantee for maximum comfort of the occupants and provide striking views. The aesthetically striking design and technical complexity of the building posed an exciting challenge to the entire planning and construction teams, especially in the development and realization of the building envelope. The completed tower is a spectacular new landmark in the Frankfurt skyline.
Die Gebäudehülle in der Kreislaufwirtschaft und die Nachhaltigkeitsziele der Vereinten Nationen
Authors: Craft Laura , Müller Christian , Marinitsch Stefan 
Published: December 2021

AbstractWir leben in beispiellosen Zeiten. Die Menschheit sieht sich mit Herausforderungen konfrontiert, deren Lösung keinen Lebensbereich unberührt lassen. Als Planer und Ingenieure müssen wir täglich Entscheidungen von gesellschaftlicher Relevanz treffen. Die Energieeffizienz eines Bauwerks steht in direkter Abhängigkeit zur Effizienz einer sorgfältig geplanten Gebäudehülle. Der Fokus auf die Betriebsenergiebilanzierung steht außer Frage. Wichtige Themen wie Materialknappheit, Energieverbrauch und CO2‐Emission während der Herstellung sowie Wasserverbrauch, Lebenszyklus und Kreislaufdenken stehen noch im Hintergrund. Dieser Beitrag möchte die Möglichkeiten als auch Grenzen diskutieren, welche uns als Planer der menschgemachten Umwelt zur Verfügung stehen.The building envelope in the circular economy and the United Nations Sustainable Development Goals. We are living in unprecedented times. As humanity we face monumental challenges and going forward the decisions we take for every aspect of our life will be pivotal for generations to come. As designers and engineers we take informed decisions every day. When designing a building, its energy performance is linked to the performance of a diligent envelope design. Throughout a design‐process, nowadays nobody questions the focus on operational energy consumption. Important questions such as scarcity of materials, energy consumption during production, carbon emission, embodied carbon, water consumption, material lifecycle and circularity to name only a few, are only slowly entering center stage. The following paper will discuss the possibilities, as well as limitations we face as designers and creators of the built environment.
Bauordnungsrechtliche und konstruktive Anforderungen für bauwerkintegrierte Photovoltaik (BIPV)
Authors: Ensslen Frank , E. Kuhn Tilmann 
Published: December 2021

AbstractNeben der Optimierung von energetischen und elektrotechnischen Leistungseigenschaften sind zur Erfüllung einer sowohl sicheren als auch zuverlässigen Fassadenintegration von BIPV‐Modulen für die Produktverwendbarkeit europäische Spezifikationen zu beachten und die Landesbauordnungen. Hinsichtlich Bemessung, Konstruktion und Ausführung sind für die als Bauart zusammengefügten PV‐Module, je nach Anwendung bzw. Funktionalität, die nationalen technischen Baubestimmungen einzuhalten. In Deutschland ergeben sich bei PV‐Modulen mit Glas an Fassaden erhöhte Anforderungen für die baupraktische Anwendung. Daher sind im Planungsprozess frühzeitig bauordnungsrechtliche und konstruktive Aspekte für ein derartiges „elektrotechnisches“ Bauprodukt zu berücksichtigen.Building code and design requirements for photovoltaics integrated into buildings (BIPV). In addition to the optimization of energetic and electrotechnical performance characteristics, European specifications and state building codes must be observed to ensure safe and reliable facade integration of BIPV modules for product usability. With regard to dimensioning, construction and design, the national technical building regulations must be observed for PV modules assembled as a construction type, depending on the application or functionality. In Germany, PV modules containing glass on facades are subject to increased requirements for practical building applications. For this reason, building regulations and design aspects for such an “electrotechnical” building product must be taken into account at an early stage in the planning process.
Entwicklung von Absturzsicherungen aus Glas – die Evolution eingespannter Brüstungen
Authors: Siebert Geralt , Siebert Barbara 
Published: December 2021

AbstractAktuell ist DIN 18008‐4 in Überarbeitung. Dies ist ein guter Zeitpunkt um zurückzuschauen, wie sich Absturzsicherungen aus Glas die letzten Jahre bzw. Jahrzehnte entwickelt haben. Geländer aus Glas wurden nicht erst mit Einführung der TRAV zu Beginn des aktuellen Jahrtausends gebaut – die Erarbeitung der TRAV war vielmehr eine Antwort auf die Vielzahl von ungeregelten Anwendungen und damit verbundenen Anträgen auf Zustimmung im Einzelfall. Ausgehend von einem kurzen Abriss der Entwicklung Technischer Regeln für Absturzsicherungen aus Glas werden Beispiele aus den letzten drei Jahrzehnten gezeigt. Glasbrüstungen mit Einspannung an der unteren horizontalen Kante wurden (mit Zustimmung der Bauaufsicht) noch Ende des letzten Jahrtausends in monolithischem ESG ausgeführt – allerdings mit (sehr) ordentlichem Handlauf. Die aktuell vielfach gewünschte maximale Transparenz akzeptiert oft nicht mal einen Kantenschutz. Beispiele aus der täglichen Praxis stellen querschnittsartig die Entwicklung dar.Development of glass balustrades – evolution of free standing, cantilevering balustrades. Currently DIN 18008‐4 is under revision. This is a good time to look back and see how anti‐drop devices made of glass have developed over the past years and decades. Glass railings were not only built with the introduction of the TRAV at the beginning of the current millennium – the development of the TRAV was rather a response to the large number of unregulated applications and the related applications for building approval in individual cases. Starting with a brief outline of the development of technical rules for fall protection systems made of glass, examples from the last three decades are shown. Glass balustrades with fixation at the lower horizontal edge were still made in monolithic ESG (with the approval of the building authorities) at the end of the last millennium – but with a (very) proper handrail. The currently often desired maximum transparency often does not even want edge protection. Examples from the daily work present a cross‐sectional view of the development.
Klebstoffauswahl zur Realisierung eines geklebten Randverbunds für flüssigkeitsgefüllte Isolierverglasungen
Authors: Joachim Alina , Nicklisch Felix , Wettlaufer Marius , Weller Bernhard 
Published: December 2021

AbstractMithilfe von Flüssigkeiten im Scheibenzwischenraum kann die Energieeffizienz von Glasfassaden gesteigert werden. In Anbetracht eines hohen ästhetischen Anspruchs an zeitgemäße Fassaden und dem Bestreben nach einem maximalen Grad an Transparenz wird ein lastabtragend geklebter Randverbund ohne zusätzliche mechanische Klemmung bevorzugt. Im Forschungsprojekt fluidIGU wird deshalb der Einsatz verschiedener Klebstoffe im Randverbund untersucht. Durch einen mehrschichtigen Aufbau soll die Beanspruchung auf verschiedene Funktionsschichten aufgeteilt werden. Dieser Beitrag gibt zunächst einen Überblick über flüssigkeitsgefüllte Fassadenelemente und zeigt den potentiellen Anwendungsbereich des geplanten Randverbundsystems auf. Des Weiteren wird das Versuchsprogramm zur Klebstoffauswahl vorgestellt, schließlich ein Einblick in aktuelle Ergebnisse gewährt und ein erstes Fazit gezogen.Selection of adhesives for the realisation of a bonded edge seal for liquid‐filled insulating glazing. The use of liquids in the space between panes is intended to increase the energy efficiency of glass facades. Considering the aesthetic demands on modern glass facades and the desire for a maximum degree of glazing, a bonded edge seal without additional mechanical clamping is preferred. The research project fluidIGU examines the use of various adhesives for edge sealing. By using a multi‐layer structure, the stress is to be distributed to different functional layers. This article gives an overview of fluid‐filled facade elements and limits the application range of the planned edge seal system. Furthermore, the experimental program for the selection of adhesives is presented, an insight into the current results is given and a first conclusion is made.
Planungsschritte zur Umsetzung eines Ganzglaspavillons nach dem Faltwerkprinzip
Authors: Schulz Isabell , Drass Michael , Teich Martien , Schneider Jens 
Published: December 2021

AbstractAnhand eines Beispielprojektes werden in diesem Beitrag die einzelnen Planungsschritte und die damit verbundenen Herausforderungen bei der Konzeption einer gläsernen Faltwerkkonstruktion beleuchtet. Dabei werden, angefangen beim architektonischen Entwurf bis hin zur statischen Bemessung und näheren Betrachtung des Verbindungsdetails, hilfreiche Planungstools und deren Grenzen vorgestellt. Neben ästhetischen und statischen Gesichtspunkten werden auch wirtschaftliche und konstruktive Aspekte der Umsetzung erörtert. Der Beitrag liefert eine Begründung, weshalb Faltwerke bisher nur selten und in wenig komplexer Ausführung Anwendung im Glasbau finden. In dieser Hinsicht zeigt sich insbesondere das Verbindungsdetail als kritische Komponente.The planning process of a glass folded plate pavilion. By the means of a specific project example this article aims to examine the planning steps and arising challenges when designing a glass folded plate structure. From the architectural to the structural design over a closer look into the connection detail helpful planning tools and their limits will be presented. Besides aesthetic and static aspects also economic factors and challenges concerning the constructive application will be addressed, aiming to give reasons why the surface‐active structural type of folded plates has yet only been scarcely represented in glass construction. Especially the connection detail reveals itself to be a critical component.
Untersuchungen zur Vernetzung EVA‐basierter Verbundfolien und daraus resultierender Eigenschaften
Authors: Bornemann Steffen , Thavayogarajah Nishanth , Riedel Kristin 
Published: December 2021

AbstractVerbundfolien, das Rückgrat von Verbundsicherheitsgläsern darstellend, gibt es in unterschiedlichen Arten, welche sich in der polymeren Struktur und auch in den Eigenschaften unterscheiden. Im Unterschied zu Verbundfolien auf Basis thermoplastischer Kunststoffe wie Polyvinylbutyral oder Ionomeren sind Verbundfolien auf Basis von thermoplastischelastomeren Ethylen‐Vinylacetat‐Copolymeren vernetzbar, was im Verarbeitungsprozess zu einem duroplastisch‐elastomeren Material führt. Art und Grad der Vernetzung lassen sich über Temperatur und Zeit steuern und führen letztendlich zu Produkten mit unterschiedlichsten Eigenschaften. Anhand praxisnaher Beispiele wird der Einfluss der Vernetzung auf die grundlegenden Eigenschaften von Verbundfolien bzw. daraus gefertigter Produkte diskutiert.Investigation of crosslinkable EVA‐based laminating films and their resulting properties. Laminating films, the backbone of laminated safety glasses, are available in different types, which differ basically in their polymer structure and also in their basic properties. In contrast to laminating films based on thermoplastics such as polyvinyl butyral or ionomers, laminating film based on thermoplastic‐elastomer like ethylene‐vinyl acetate co‐polymer is crosslinkable, which results in a thermoset‐elastomeric material after the lamination process. The type and degree of crosslinking can be controlled by temperature and time, which ultimately leads to products with different properties. Adding some practical applications, the influence of crosslinking on the basic properties of laminating films or rather on the end products is discussed here.
Tetra‐Substituted p‐Tert‐Butylcalix[4]Arene with Phosphoryl and Salicylamide Functional Groups: Synthesis, Complexation and Selective Extraction of f‐Element Cations
Authors: Glasneck Florian , Roode‐Gutzmer Quirina I. , Stumpf Thorsten , Kersting Berthold 
Published: December 2021

AbstractA new series of lanthanide (1–5) and uranyl (6) complexes with a tetra‐substituted bifunctional calixarene ligand H2L is described. The coordination environment for the Ln3+ and UO22+ ions is provided by phosphoryl and salicylamide functional groups appended to the lower rim of the p‐tert‐butylcalix[4]arene scaffold. Ligand interactions with lanthanide cations (light: La3+, Pr3+; intermediate: Eu3+ and Gd3+; and heavy: Yb3+), as well as the uranyl cation (UO22+) is examined in the solution and solid state, respectively with spectrophotometric titration and single crystal X‐ray diffractometry. The ligand is fully deprotonated in the complexation of trivalent lanthanide ions forming di‐cationic complexes 2 : 2 M : L, [Ln2(L)2(H2O)]2+ (1–5), in solution, whereas uranyl formed a 1 : 1 M : L complex [UO2(L)(MeOH)]∞ (6) that demonstrated very limited solubility in 12 organic solvents. Solvent extraction behaviour is examined for cation selectivity and extraction efficiency. H2L was found to be an effective extracting agent for UO22+ over La3+ and Yb3+ cations. The separation factors at pH 6.0 are: βUO
/La
=121.0 and βUO
/Yb
=70.0.
Carrier Protein‐Free Enzymatic Biaryl Coupling in Arylomycin A2 Assembly and Structure of the Cytochrome P450 AryC
Authors: Aldemir Hülya , Shu Shuangjie , Schaefers Francoise , Hong Hanna , Richarz René , Harteis Sabrina , Einsiedler Manuel , Milzarek Tobias M. , Schneider Sabine , Gulder Tobias A. M. 
Published: December 2021

AbstractInvited for the cover of this issue are Sabine Schneider, Tobias A. M. Gulder and co‐workers at Technical University of Dresden, Technical University of Munich and Ludwig‐Maximillians‐University Munich. The image depicts the crystal structure of the cytochrome P450 AryC from arylomycin biosynthesis. Read the full text of the article at 10.1002/chem.202103389.
Regio‐ and Diasteroselective C‐Silylation of Enolate Enabled by a β‐Boronyl Group
Authors: Liu Yu , Zhan Miao , Li Pengfei 
Published: December 2021

Comprehensive SummarySilyl enol ethers are often obtained when the lithium enolates are trapped with chlorosilanes. Herein, we report a general method for the regio‐ and diasteroselective C‐silylation of enolate enabled by the β‐boronyl group. The formation of five‐membered chelation intermediate is key to the C‐selective silylation and anti‐selectivity. The operationally simple protocol provides a general and predictable access to the α‐silylated esters. The synthetic versatility of the boron–silicon bifunctional products was demonstrated by down‐stream transformations.
Prescribing Morse Scalar Curvatures: Pinching and Morse Theory
Authors: Malchiodi Andrea , Mayer Martin 
Published: December 2021

AbstractWe consider the problem of prescribing conformally the scalar curvature on compact manifolds of positive Yamabe class in dimension . We prove new existence results using Morse theory and some analysis on blowing‐up solutions under suitable pinching conditions on the curvature function. We also provide new nonexistence results showing the sharpness of some of our assumptions, both in terms of the dimension and of the Morse structure of the prescribed function. © 2021 Wiley Periodicals, Inc.
Comprehensive Guide to Extracting and Expressing Fungal Secondary Metabolites with Aspergillus fumigatus as a Case Study
Authors: Nickles Grant , Ludwikoski Isabelle , Bok Jin Woo , Keller Nancy P. 
Published: December 2021

AbstractFungal secondary metabolites (SMs) have captured the interest of natural products researchers in academia and industry for decades. In recent years, the high rediscovery rate of previously characterized metabolites is making it increasingly difficult to uncover novel compounds. Additionally, the vast majority of fungal SMs reside in genetically intractable fungi or are silent under normal laboratory conditions in genetically tractable fungi. The fungal natural products community has broadly overcome these barriers by altering the physical growth conditions of the fungus and heterologous/homologous expression of biosynthetic gene cluster regulators or proteins. The protocols described here summarize vital methodologies needed when researching SM production in fungi. We also summarize the growth conditions, genetic backgrounds, and extraction protocols for every published SM in Aspergillus fumigatus, enabling readers to easily replicate the production of previously characterized SMs. Readers will also be equipped with the tools for developing their own strategy for expressing and extracting SMs from their given fungus or a suitable heterologous model system. © 2021 Wiley Periodicals LLC.Basic Protocol 1: Making glycerol stocks from spore suspensionsAlternate Protocol 1: Creating glycerol stocks from non‐sporulating filamentous fungiBasic Protocol 2: Activating spore‐suspension glycerol stocksBasic Protocol 3: Extracting secondary metabolites from Aspergillus spp grown on solid mediumAlternate Protocol 2: Extracting secondary metabolites from Aspergillus spp using ethyl acetateAlternate Protocol 3: High‐volume metabolite extraction using ethyl acetateAlternate Protocol 4: Extracting secondary metabolites from Aspergillus spp in liquid mediumSupport Protocol: Creating an overlay cultureBasic Protocol 4: Extracting DNA from filamentous fungiBasic Protocol 5: Creating a DNA construct with double‐joint PCRAlternate Protocol 5: Creating a DNA construct with yeast recombineeringBasic Protocol 6: Transformation of Aspergillus sppBasic Protocol 7: Co‐culturing fungi and bacteria for extraction of secondary metabolites
Chloride Deficiency and Toxicity Can Be a Real Problem
Authors: Winsor Susan 
Published: December 2021

AbstractThe micronutrient chloride (Cl–) is one of 17 essential nutrients for plant survival. Chloride deficiency can be an issue in wheat, barley, oat, corn, and grain sorghum. In other species, like soybeans and rice, too much chloride can hurt yields. This article will cover deficiency symptoms, fertilizer tips and reported yield responses, and chloride toxicity. Earn 1 CEU in Nutrient Management by reading the article and taking the quiz at https://bit.ly/3xNu1sf. View all CEUs online at https://web.sciencesocieties.org/Learning‐Center/Courses.
Nutrient Stewardship: Taking 4R Further
Authors: Bruulsema Tom 
Published: December 2021

AbstractIt’s been 10 years since the 4R Plant Nutrition manual was published, setting out principles for the stewardship of plant nutrients agreed to by soil fertility scientists and crop nutrition practitioners. Since then, the industry has done a lot to implement the concept, both globally and in North America. What has been learned and accomplished in the process? What needs to be done to take 4R further? Earn 1 CEU in Nutrient Management by reading this article and taking the quiz at https://bit.ly/3potolp. View all CEUs online at https://web.sciencesocieties.org/Learning‐Center/Courses.
Bayesian GGE model for heteroscedastic multienvironmental trials
Authors: de Oliveira Luciano Antonio , da Silva Carlos Pereira , da Silva Alessandra Querino , Mendes Cristian Tiago Erazo , Nuvunga Joel Jorge , Nunes José Airton Rodrigues , Parrella Rafael Augusto da Costa , Baleste Marcio , Filho Júlio Sílvio de Sousa Bueno 
Published: December 2021

AbstractThe dissection of genotype × environment interaction (GEI) is a crucial aspect of the final stages of plant breeding pipelines and recommendation of cultivars. Linear‐bilinear models used to analyze this interaction, such as the additive main effects and multiplicative interaction (AMMI) and genotype plus GEI (GGE), often assume homogeneity of the residual variances across environments which affects the estimates and therefore, interpretations and conclusions. Our main objective was to propose a GGE model that considers heteroscedasticity across environments using Bayesian inference and to evaluate its implications in the interpretation of real and simulated data. The GGE model assuming common variance was also fitted for comparison purposes. The great flexibility of the Bayesian inference is transferred to the biplots, allowing the construction of credible regions for genotypic and environmental scores. The inference on the stability and adaptability of genotypes might change when heteroscedasticity is ignored. When real data are used, different patterns of correlations between environments also affect the representativeness and discrimination of the target environment. The modeling of heteroscedasticity allowed the clustering of environments into subgroups, with similar effects for GEI. The proposed GGE model was more adequate and realistic to deal with scenarios of heterogeneous variance in multienvironment trials, which can be useful for exploiting the GEI.
Efficiency‐Enhanced Scalable Organic Photovoltaics Using Roll‐to‐Roll Nanoimprint Lithography
Authors: Yakoob Mohammed A. , Lamminaho Jani , Petersons Karlis , Prajapati Ashish , Destouesse Elodie , Patil Bhushan R. , Rubahn Horst‐Günter , Shalev Gil , Stensborg Jan , Madsen Morten 
Published: December 2021

AbstractInvited for this month′s cover is the group of Prof. Morten Madsen, University of Southern Denmark, together with Stensborg A/S and Dr. Shalev's group at the Ben‐Gurion University of the Negev. The image shows the integration of Roll‐to‐Roll (R2R) light‐management foils to enhance efficiency of R2R organic photovoltaics. The Full Paper itself is available at 10.1002/cssc.202101611.