bluuebunny/crossref_metadata_2025_split huggingface dataset:
La Hora de la Salsa: Nicolás Maduro and the Political Dimensions of Salsa in Venezuela
Authors: Bellaviti Sean 
Published: March 2021

AbstractIn this article I examine how, during a period of extreme social unrest, Venezuelan President Nicolás Maduro took up the role of a salsa radio deejay as a show of confidence in his hold on political power and of his solidarity with ordinary Venezuelans. I argue that this all but unprecedented and, for many, controversial course of action by a sitting president provides us with an unusual opportunity to analyse Venezuela's long-standing political crisis. In particular, I highlight how Maduro harnessed salsa's long association with poor Latin Americans, its connection to Venezuela and its pleasurable character to bolster his socialist credentials, and I show how this strategy unleashed a public exchange of criticisms with one legendary salsero (salsa musician), Rubén Blades. By exploring the way music intersects with politics, I show how popular culture is neither ancillary to nor derivative of the country's ever-deepening strife but, rather, constitutive of it.
“Against Right and Reason”: The Bold but Smooth French Take-Over of Dutch Cayenne (1655–1664)
Authors: van den Bel Martijn 
Published: March 2021

AbstractThe Dutch loss of Brazil in 1654 favoured the resettlement of Dutch merchants along the Wild Coast and in the Lesser Antilles and the establishment of new colonies. Cayenne Island was one of them. One WIC patent was handed to Jan Claes Langedijck, who settled at the former French fort of Cépérou, and another patent was given to David Nassy, who settled in the Anse de Rémire, situated at the opposite part of the former island. Both colonies were taken by the French in May 1664 as part of the imperial French expansion under King Louis XIV and Jean-Baptist Colbert. It is argued here that the main French goal was to gain control of the sugar plantations of the Sephardic community located there, and, to a lesser extent, the much-desired territorial control of this region as proposed by the newly established French West India Company. The Dutch were aware of the attack, but could not intervene as it was already too late to send support to the poorly defended Cayenne colony. Both parties negotiated the take-over and the majority of the Dutch settlers stayed under French rule, as was suggested by the Dutch government and hoped for by the French.
BEYOND LINGUISTIC FEATURES
Authors: Nagle Charles L. , Trofimovich Pavel , O’Brien Mary Grantham , Kennedy Sara 
Published: March 2021

AbstractComprehensibility, or ease of understanding, has emerged as an important construct in second language (L2) speech research. Many studies have examined the linguistic features that underlie this construct, but there has been limited work on behavioral and affective predictors. The goal of this study was therefore to examine the extent to which anxiety and collaborativeness predict interlocutors’ perception of one another’s comprehensibility. Twenty dyads of L2 English speakers completed three interactive tasks. Throughout their 17-minute interaction, they were periodically asked to evaluate their own and each other’s anxiety and collaborativeness and to rate their partner’s comprehensibility using 100-point scales. Mixed-effects models showed that partner anxiety and collaborativeness predicted comprehensibility, but the relative importance of each predictor depended on the nature of the task. Self-collaborativeness was also related to comprehensibility. These findings suggest that comprehensibility is sensitive to a range of linguistic, behavioral, and affective influences.
Exploring into contributing factors to young seafarer turnover: empirical evidence from China
Authors: Bao Junzhong , Li Yan , Zheng Guoping , Zhang Pengfei 
Published: March 2021

AbstractVarious studies suggest that the maritime industry will continue to face the challenge of seafarer shortages. Young seafarer turnover has become a serious issue that cannot be underestimated. This paper aims to identify the root causes of young seafarer attrition in China and explore relevant solutions. It collects information via semi-structured interviews and questionnaires. Independent sample t-test, one-way ANOVA and least-significant difference are utilised for the variance analysis. The findings of the study show that occupational recognition and family responsibility are the two major factors contributing to young seafarers’ outflow. Chinese seafarers’ health status is another important factor that has received little attention. In addition, young seafarers of 31–35 years old have the most possibility of turnover, due to a number of reasons discussed in this paper. Age 40 or thereabouts is viewed as the watershed moment in a seafarer's career, so efforts should be made to help young seafarers pass through the hard period in their early thirties. This paper suggests that a clear career plan could be a potential solution to retain this backbone group as prospective senior officers.
An Illustrated Shiʿi Pilgrimage Scroll in the Collections of the Royal Asiatic Society
Authors: MARZOLPH ULRICH , RENAULD MATHILDE 
Published: March 2021

AbstractThe collections of the Royal Asiatic Society hold an illustrated pilgrimage scroll apparently dating from the first half of the nineteenth century. The scroll's hand painted images relate to the journey that a pious Shiʿi Muslim would have undertaken after the performance of the pilgrimage to Mecca. Its visual narrative continues, first to Medina and then to the Shiʿi sanctuaries in present-day Iraq, concluding in the Iranian city of Mashhad at the sanctuary of the eighth imam of the Twelver-Shiʿi creed, imam Riḍā (d. 818). The scroll was likely prepared in the early nineteenth century and acquired by the Royal Asiatic Society from its unknown previous owner sometime after 1857. In terms of chronology the pilgrimage scroll fits neatly into the period between the Niebuhr scroll, bought in Karbala in 1765, and a lithographed item most likely dating from the latter half of the nineteenth century, both of which depict a corresponding journey. The present essay's initial survey of the scroll's visual dimension, by Ulrich Marzolph, adds hitherto unknown details to the history of similar objects. The concluding report, by Mathilde Renauld, sheds light on the scroll's material condition and the difficulties encountered during the object's conservation and their solution.
Complex transformation of divorce in Vietnam under the forces of modernization and individualism
Authors: Thi Minh Thi Tran 
Published: March 2021

AbstractAfter more than four decades since its reunification since 1975, Vietnam has achieved remarkable results in social and economic development. With the rapid speed of recent modernization, society has loosened numerous old values related to the family and promoted individual freedoms. Marriage and family affairs, including divorce, have modernized with liberal characteristics. The paper examines the trends of divorce and reasons for divorce using statistical data from the Vietnam People's Supreme Court and from the government's annual population statistics. The analysis compiled and analysed a database of every divorce case at six urban and rural districts in Can Tho province. The analysis highlights changes in the reasons for divorce in the South in comparison with previous divorce studies in the North of Vietnam, discussed in relation to modernization, individualism and gender equality. The analysis is supported by interview data with thirty male and female divorcees.
Prevalence of Shallow Low‐Frequency Earthquakes in the Continental Crust
Authors: Nakajima Junichi , Hasegawa Akira 
Published: March 2021

AbstractLow‐frequency earthquakes (LFEs) that predominantly occur at depths of 20–30 km are categorized as a particular class of earthquakes whose spectral power is concentrated at 1–4 Hz. While the tectonic LFEs along megathrust boundaries occur as shear failure, the genesis of LFEs in the continental plate is poorly understood due to the diversity of focal mechanism solutions. Here we conduct a systematic survey of LFEs using two metrics (frequency index and peak frequency) that characterize the frequency content of the waveforms, and show that LFEs are prevalent in the upper crust beneath the Japanese Islands, even in non‐volcanic regions. Shallow LFEs are most common near tectonic boundaries and are temporarily activated in the aftershock sequences of large (M ≥ 6.5) crustal earthquakes. The widespread distribution of shallow LFEs suggests that a lower crustal rheology is not necessary for their genesis. We infer that failure along frictionally weakened faults due to high pore‐fluid pressures is a primary control for the enrichment of low‐frequency energy. The observed differences in the frequency content are probably due to differences in the pore‐fluid pressure along each fault, which influences the rupture velocity and magnitude of the tensile component during shear failure. Our observations may lead to a more unified model of earthquake generation, thereby providing a better understanding of how earthquakes release the stress accumulated in the Earth.
Surf Zone Waves at the Onset of Breaking: 1. LIDAR and IR Data Fusion Methods
Authors: Carini Roxanne J. , Chickadel C. Chris , Jessup Andrew T. 
Published: March 2021

AbstractThis is the first of a 2‐part series concerning remote observation and wave‐by‐wave analysis of the onset of breaking in the surf zone. In the surf zone, breaking waves drive nearshore circulation, suspend sediment, and promote air‐sea gas exchange. Nearshore wave model predictions often diverge fromin situmeasurements near the break point location because common parameterizations do not account for the rapid changes that occur near the onset of breaking. This work presents extensive methodology to combine data from a line‐scanning LIDAR and thermal infrared cameras to detect breaking, classify breaker type, and measure geometric wave parameters on a wave‐by‐wave basis, which can be used to improve breaker parameterizations. Over 2,600 non‐breaking and 1,600 breaking waves are analyzed from data collected at the USACE Field Research Facility in Duck, NC, including 413 spilling and 111 plunging waves for which the onset of breaking was observed. Wave height is estimated using a spatio‐temporal method for wave tracking that preserves the sea surface elevation maximum and overcomes field of view limitations. Methods for estimating instantaneous wave speed are refined by fitting a skewed Gaussian function to each wave profile before tracking the peaks. Wave slope is estimated from a linear fit to the upper 80% of the wave face, which provides a robust metric and strong correlation with geometric wave slope defined relative to mean sea level. Finally, breaking wave face foam coverage is analyzed to assess common model assumptions about roller length for wave energy dissipation parameterizations.
Developmental programming of offspring adipose tissue biology and obesity risk
Authors: Rodgers Amanda , Sferruzzi-Perri Amanda N. 
Published: March 2021

AbstractObesity is reaching epidemic proportions and imposes major negative health crises and an economic burden in both high and low income countries. The multifaceted nature of obesity represents a major health challenge, with obesity affecting a variety of different organs and increases the risk of many other noncommunicable diseases, such as type 2 diabetes, fatty liver disease, dementia, cardiovascular diseases, and even cancer. The defining organ of obesity is the adipose tissue, highlighting the need to more comprehensively understand the development and biology of this tissue to understand the pathogenesis of obesity. Adipose tissue is a miscellaneous and highly plastic endocrine organ. It comes in many different sizes and shades and is distributed throughout many different locations in the body. Though its development begins prenatally, quite uniquely, it has the capacity for unlimited growth throughout adulthood. Adipose tissue is also a highly sexually dimorphic tissue, patterning men and women in different ways, which means the risks associated with obesity are also sexually dimorphic. Recent studies show that environmental factors during prenatal and early stages of postnatal development have the capacity to programme the structure and function of adipose tissue, with implications for the development of obesity. This review summarizes the evidence for a role for early environmental factors, such as maternal malnutrition, hypoxia, and exposure to excess hormones and endocrine disruptors during gestation in the programming of adipose tissue and obesity in the offspring. We will also discuss the complexity of studying adipose tissue biology and the importance of appreciating nuances in adipose tissue, such as sexual dimorphism and divergent responses to metabolic and endocrine stimuli. Given the rising levels of obesity worldwide, understanding how environmental conditions in early life affects adipose tissue phenotype and the subsequent development of obesity is of absolute importance.
Use of a non-invasive accelerometric method for diagnosing gastroesophageal reflux in premature infants
Authors: Gewolb Ira H. , Vice Frank L. 
Published: March 2021

AbstractObjectiveTo evaluate the clinical usefulness of a non-invasive accelerometric device to diagnose GER in preterm babies.Study designAn accelerometer was taped over the sub-xiphoid process in 110 preterm (GA 29.6 ± 3.3 wk) infants (133 studies). Low frequency, sub-audible signals were captured via digital recording (sampling rate 200 Hz), then re-sampled (rate = 60 Hz) to create a spectrogram (focused range 0–30 Hz). Mean amplitude in the focused range was calculated.ResultsOf 85 studies with simultaneous pH-metry and accelerometry, 18 had concurrent positive and 23 had concurrent negative scores, 42 had negative pH scores when accelerometry was positive (≥1 µV), consistent with non-acid reflux. Eleven infants at high risk of aspiration received surgical interventions. All but 1 had negative pH scores while 10/11 had positive accelerometry.ConclusionsThe non-invasiveness of this accelerometric technique allows for GER screening and for repeated testing to assess efficacy of interventions.
Prenatally traumatized mice reveal hippocampal methylation and expression changes of the stress-related genes Crhr1 and Fkbp5
Authors: Plank Anne-Christine , Frey Stefan , Basedow Lukas Andreas , Solati Jalal , Canneva Fabio , von Hörsten Stephan , Kratz Oliver , Moll Gunther H. , Golub Yulia 
Published: March 2021

AbstractIn our previous study, we found that prenatal trauma exposure leads to an anxiety phenotype in mouse pups, characterized by increased corticosterone levels and increased anxiety-like behavior. In order to understand the mechanisms by which aversive in utero experience leads to these long-lasting behavioral and neuroendocrine changes, we investigated stress reactivity of prenatally traumatized (PT) mice, as well as the expression and methylation levels of several key regulatory genes of the stress axis in the dorsal hippocampus (dHPC) of the PT embryo and adult mice. We detected increased corticotropin-releasing hormone receptor 1 (Crhr1) and decreased FK506 binding protein 5 (Fkbp5) mRNA levels in the left dHPC of adult PT mice. These alterations were accompanied by a decreased methylation status of the Crhr1 promoter and an increased methylation status of the Fkbp5 promoter, respectively. Interestingly, the changes in Fkbp5 and Crhr1 mRNA levels were not detected in the embryonic dHPC of PT mice. Together, our findings provide evidence that prenatal trauma has a long-term impact on stress axis function and anxiety phenotype associated with altered Crhr1 and Fkbp5 transcripts and promoter methylation.
Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice
Authors: Wörner Stefan , Bohnert Bernhard N. , Wörn Matthias , Xiao Mengyun , Janessa Andrea , Birkenfeld Andreas L. , Amann Kerstin , Daniel Christoph , Artunc Ferruh 
Published: March 2021

AbstractTreatment with aprotinin, a broad-spectrum serine protease inhibitor with a molecular weight of 6512 Da, was associated with acute kidney injury, which was one of the reasons for withdrawal from the market in 2007. Inhibition of renal serine proteases regulating the epithelial sodium channel ENaC could be a possible mechanism. Herein, we studied the effect of aprotinin in wild-type 129S1/SvImJ mice on sodium handling, tubular function, and integrity under a control and low-salt diet. Mice were studied in metabolic cages, and aprotinin was delivered by subcutaneously implanted sustained release pellets (2 mg/day over 10 days). Mean urinary aprotinin concentration ranged between 642 ± 135 (day 2) and 127 ± 16 (day 8) µg/mL . Aprotinin caused impaired sodium preservation under a low-salt diet while stimulating excessive hyperaldosteronism and unexpectedly, proteolytic activation of ENaC. Aprotinin inhibited proximal tubular function leading to glucosuria and proteinuria. Plasma urea and cystatin C concentration increased significantly under aprotinin treatment. Kidney tissues from aprotinin-treated mice showed accumulation of intracellular aprotinin and expression of the kidney injury molecule 1 (KIM-1). In electron microscopy, electron-dense deposits were observed. There was no evidence for kidney injury in mice treated with a lower aprotinin dose (0.5 mg/day). In conclusion, high doses of aprotinin exert nephrotoxic effects by accumulation in the tubular system of healthy mice, leading to inhibition of proximal tubular function and counterregulatory stimulation of ENaC-mediated sodium transport.
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion
Authors: Wang Wenwen , Zhai Dongsheng , Bai Yongquan , Xue Ke , Deng Lele , Ma Lirong , Du Tianshu , Ye Zicheng , Qu Di , Xiang An , Chen Guo , Zhao Yi , Wang Li , Lu Zifan 
Published: March 2021

AbstractInflammatory bowel disease (IBD) is a refractory chronic inflammatory illness of the gastrointestinal (GI) tract. Macrophage exerts an important role in IBD development. QKI, as an RNA binding protein, was related with inflammatory responses in bacterial infections by regulating the polarization of macrophages. Therefore, we suspected that QKI-regulated macrophages have the potential to play a certain role in IBD and the underlying mechanism. Our results demonstrated that the mice with macrophage-specific deletion of QKI induced with dextran sodium sulfate (DSS) are more susceptible to IBD development, exhibited a severe leaky gut barrier phenotype and higher intense oxidative stress, which are rescued by treating with butylated hydroxyanisole (BHA), an agonist of NRF2. Mechanically, we observed that Keap1 mRNA in the nucleus was exported to the cytoplasm after LPS stimuli in parallel with QKI reductions, and the removal of QKI by shRNA facilitated Keap1 mRNA nuclear exporting and expression in cytoplasm, consequently NRF2 activation in nucleus was weakened, and led to the impaired antioxidant abilities. In addition, mice models of fecal microbiota transplant (FMT) and the co-culturing of mice epithelia cells with feces derived from the DSS-treated QKI-deficit mice revealed consistently aggravated colitis along with a severe oxidative stress; 16S sequencing analysis substantiated the altered compositions of commensal bacteria too. Overall, the current study represents the first effort to explore the anti-oxidant role of QKI in the intestinal macrophage via post-transcriptional regulation of Keap1 mRNA localization and the relevant NRF2 antioxidant signaling, and the disproportional changes in the microbiota were attributable to the mediation of pathogenic damage in the IBD development of QKI-deficit mice.
Translation error clusters induced by aminoglycoside antibiotics
Authors: Wohlgemuth Ingo , Garofalo Raffaella , Samatova Ekaterina , Günenç Aybeg Nafiz , Lenz Christof , Urlaub Henning , Rodnina Marina V. 
Published: March 2021

AbstractAminoglycoside antibiotics target the ribosome and induce mistranslation, yet which translation errors induce bacterial cell death is unclear. The analysis of cellular proteins by quantitative mass spectrometry shows that bactericidal aminoglycosides induce not only single translation errors, but also clusters of errors in full-length proteins in vivo with as many as four amino acid substitutions in a row. The downstream errors in a cluster are up to 10,000-fold more frequent than the first error and independent of the intracellular aminoglycoside concentration. The prevalence, length, and composition of error clusters depends not only on the misreading propensity of a given aminoglycoside, but also on its ability to inhibit ribosome translocation along the mRNA. Error clusters constitute a distinct class of misreading events in vivo that may provide the predominant source of proteotoxic stress at low aminoglycoside concentration, which is particularly important for the autocatalytic uptake of the drugs.
Quantum measurement arrow of time and fluctuation relations for measuring spin of ultracold atoms
Authors: Jayaseelan Maitreyi , K. Manikandan Sreenath , Jordan Andrew N. , Bigelow Nicholas P. 
Published: March 2021

AbstractThe origin of macroscopic irreversibility from microscopically time-reversible dynamical laws—often called the arrow-of-time problem—is of fundamental interest in both science and philosophy. Experimentally probing such questions in quantum theory requires systems with near-perfect isolation from the environment and long coherence times. Ultracold atoms are uniquely suited to this task. We experimentally demonstrate a striking parallel between the statistical irreversibility of wavefunction collapse and the arrow of time problem in the weak measurement of the quantum spin of an atomic cloud. Our experiments include statistically rare events where the arrow of time is inferred backward; nevertheless we provide evidence for absolute irreversibility and a strictly positive average arrow of time for the measurement process, captured by a fluctuation theorem. We further demonstrate absolute irreversibility for measurements performed on a quantum many-body entangled wavefunction—a unique opportunity afforded by our platform—with implications for studying quantum many-body dynamics and quantum thermodynamics.
Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
Authors: Kim KyeongJin , Kang Jin Ku , Jung Young Hoon , Lee Sang Bae , Rametta Raffaela , Dongiovanni Paola , Valenti Luca , Pajvani Utpal B. 
Published: March 2021

AbstractIncreased adiposity confers risk for systemic insulin resistance and type 2 diabetes (T2D), but mechanisms underlying this pathogenic inter-organ crosstalk are incompletely understood. We find PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2), recently identified as the Akt Ser473 phosphatase, to be increased in adipocytes from obese mice. To identify the functional consequence of increased adipocyte PHLPP2 in obese mice, we generated adipocyte-specific PHLPP2 knockout (A-PHLPP2) mice.A-PHLPP2mice show normal adiposity and glucose metabolism when fed a normal chow diet, but reduced adiposity and improved whole-body glucose tolerance as compared to Cre- controls with high-fat diet (HFD) feeding. Notably, HFD-fedA-PHLPP2mice show increased HSL phosphorylation, leading to increased lipolysis in vitro and in vivo. Mobilized adipocyte fatty acids are oxidized, leading to increased peroxisome proliferator-activated receptor alpha (PPARα)-dependent adiponectin secretion, which in turn increases hepatic fatty acid oxidation to ameliorate obesity-induced fatty liver. Consistently, adipose PHLPP2 expression is negatively correlated with serum adiponectin levels in obese humans. Overall, these data implicate an adipocyte PHLPP2-HSL-PPARα signaling axis to regulate systemic glucose and lipid homeostasis, and suggest that excess adipocyte PHLPP2 explains decreased adiponectin secretion and downstream metabolic consequence in obesity.