bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol consumption during the coronavirus epidemic in Russia
Authors: Nemtsov A. V. , Gridin R. V. 
Published: August 2021

The aim of the study is to assess alcohol consumption during the coronavirus epidemic in Russia.Materials and methods – retail sales of alcoholic beverages, which account for about 70% of the alcohol market in the country, as well as online inquiries for the delivery of illegal vodka were assessed. The assessment of changes was made on the basis of a comparison of the period March 2020-March 2021 with the average 2018–2019, and in the case of sales growth in 2018–2019 – based on average and linear regression. Internet requests for the delivery of vodka were obtained from the portals Google Trends and Yandex. The purchasing power of the population was assessed by the dynamics of the real money incomes of the population of the Russian Federation.Results – sales changes were ambiguous, both for diﬀerent drinks, and in the two waves of the epidemic. Alcohol spirits increased both in the frst (by 2.2%) and in the second half of the year (by 1.2%), despite a decrease in cognac sales due to an increase in MRP by 11.6% from January 2020. Wine sales decreased during the epidemic, but this is due to a number of administrative and legislative measures, as well as a twofold decline in production. During the epidemic, retail beer sales grew by 4.5% in the frst half of the year, and decreased by 3.4% in the second. Internet searches for the illegal delivery of vodka rose sharply at the very beginning of the epidemic (after March 22, 2020) and two weeks later reached a maximum (202.9 thousand per week; Yandex), exceeding the February level by 2.7 times. Further, the dynamics of online searches corresponded to the waves of the epidemic.Conclusions. The coronavirus epidemic was accompanied by an increase in the consumption of hard alcohol from various sources. It has been suggested that distress was the dominant factor in the growth of strong alcohol consumption during the coronavirus epidemic, despite the decline in the purchasing power of the population, especially during the second wave of the epidemic.
Vendian Hydrogeochemistry of the Siberian Platform
Authors: Novikov D.A. , Chernykh A.V. , Konstantinova L.N. , Dultsev F.F. , Yurchik I.I. 
Published: August 2021

Abstract
—The Vendian deposits of the Siberian Platform are represented by four regional horizons (from bottom to top): Nepa, Vilyuchan, Tira, and Danilovka. The TDS of brines in the Nepa and Vilyuchan horizons varies from 170.3 to 470.1 g/L, and the TDS in the overlying Tira and Danilovka horizons, from 84.6 to 583.1 g/L. Brines of Cl Na, Cl Na–Ca, Cl Ca–Na, Cl Ca, and Cl Ca–Mg types have been identified. The pH values of the brines vary from 3.0 to 7.0; acidic and weakly acidic brines (pH = 3.0–5.5) prevail. The redox potential Eh varies from –440 mV (highly reducing conditions) to +130 mV (oxidizing conditions), averaging –176 mV. Areal regional hydrogeochemical zoning is controlled by the outer (on the periphery of the Siberian Platform, where infiltration of meteoric waters took place) and inner feeding areas. The outer feeding areas bear infiltrogenic brines of different ages (group I), mostly of Cl Na composition. They are characterized by TDS ≤ 280 g/L, rNa/rCl ≤ 1.55, Cl/Br ≤ 2512, and average Ca/Cl = 0.3. The average values of the integrated brine metamorphization index S (according to S.L. Shvartsev) range from 50 to 200. In the intraplatform feeding areas, there are several phases of brines that underwent gravitational sinking into the Vendian horizons in the periods when Cambrian salt-bearing basins existed on the platform. These brines were metamorphosed during filtration along the fracture and fault zones. The intrusion of traps in the late Permian–early Triassic was accompanied by hydrothermal activity. The waters of the enclosing Cambrian dolomite horizons were heated to 800–1000 °C; their subsequent interaction with carbonate rocks and evaporites (in particular, chlorides) resulted in extrastrong saturated brines. These brines were also subjected to gravitational sinking into the Vendian reservoirs, which was the main cause of the inverse vertical hydrogeochemical zoning in the hydrogeologic subsalt formation. The brine metamorphism processes and temperature changes in the rock horizons during the intrusion of traps and their subsequent cooling led to a significant alteration of the enclosing rocks under interaction with brines and to salinization of the reservoirs, an increase in the total salinity of the brines, and catagenetic changes in their composition. The brines closest to the maximum saturation with halite were found in reservoir zones with the highest salinization and near faults and boundaries of intrusive bodies. During the pre-Vilyuchan, pre-Nepa, pre-Tira, and pre-Danilovka sedimentation breaks, infiltrogenic waters penetrated into the Vendian sediments. Geochemically, the sedimentogenic, infiltrogenic, and metamorphic strong brines (group II) have a predominantly Cl Ca or Cl Ca–Mg composition with TDS &gt; 350 g/L. They are characterized by low rNa/rCl ratios (on average, 0.3), Cl/Br ≤ 100, high Ca/Cl values (on average, 0.4), and S &gt; 250.
ConocoPhillips’ Water-Hammer Analysis Highlights Potential for a Complex Dataset
Authors: Jacobs Trent 
Published: August 2021

It has often amounted to little more than background noise. Now, engineers with one of the largest shale producers in the US consider the water-hammer signal to represent a potential trove of insight into stimulation performance.
ConocoPhillips has spent almost 3 years developing a new approach to water-hammer analysis and recently shared the first public details of that work in a technical paper (SPE 204154). Perhaps the core takeaway is that within a few minutes of post-stage data, a picture of reservoir and stimulation quality is available. The challenge lies in how to bring that picture into proper focus.
The water hammer is a pressure pulse that moves through the wellbore at the speed of sound in fluid, or around 5,000 ft/s, which is more than four-fold the speed of sound in air. Its name comes from the often-audible slam made on one end of the pipe when a column of moving fluid is slowed or halted.
One is usually generated as a valve is turned, or a pump slowed or stopped at the end of a fracture stage. This makes the water hammer ubiquitous in the context of hydraulic-fracturing operations the world over.
As the wave bounces up and down the wellbore it generates noticeable pressure spikes on wellhead gauges. These oscillating signatures have been the subject of industry intrigue for decades. They’ve also proven to be difficult to decipher and trust.
As such, the water hammer has not entered into the shale sector’s pantheon of fracture-design inputs. ConocoPhillips’ ongoing research and development project may help change that.
Based on a review of treatment data from more than 150 of the operator’s low-permeability wells from an unnamed field in North America, those with fast-decaying water-hammer signals amounted to the best performers, achieving an output equivalent to 94–110% of their estimated recoveries. On the other hand, wells with more prolonged or low decay rates commonly fell 10–20% below their original type curve.
“The high decay rates indicated more near-wellbore fracture surface area, which related to higher well productivity. While conversely, low decay rates mean less near-wellbore friction, longer fractures, lower well productivity,” explained Dung “Zoom” Nguyen.
Nguyen is a staff completions engineer at ConocoPhillips and coauthor of the paper that she presented at the annual SPE Hydraulic Fracturing Technology Conference in May. She elaborated that analysis on frac hits, or fracture-driven interactions (FDIs), supports the relationship between fracture geometry and water-hammer decay rates, i.e., low decay rates equate to fewer, longer, and less-complex fractures.
Cybersecurity: The Forever Problem
Authors: Wright Blake 
Published: August 2021

The oil and gas business has become as much about bytes as barrels in recent years. Artificial intelligence, the internet of things (IoT), big data, and the ongoing digitization of the industry have not only made it a more-efficient machine but also a target to unscrupulous sorts looking to confound, cash in, and move on. As more information comes forward regarding the May 2021 ransomware attack on Colonial Pipeline, it appears to have been a cash grab with the knock-on effect of physically crippling the company’s flow of fuel to East Coast states.
The outage was never the goal, but what it if had been? That question, or one similar, was part of what got the US Department of Homeland Security (DHS) involved and the subsequent announcement of a Security Directive that will require critical-pipeline owners and operators to report confirmed and potential cybersecurity incidents to the DHS Cybersecurity and Infrastructure Security Agency (CISA) and to designate a cybersecurity coordinator, to be available 24 hours a day, 7 days a week. It will also require critical-pipeline owners and operators to review their current practices as well as to identify any gaps and related remediation measures to address cyber-related risks and report the results to the Transportation Security Administration and CISA within 30 days.
The bad guys made off with over $4 million in the Colonial attack; however, the US Department of Justice was able to recover about $2.3 million in the cryptocurrency paid by the pipeline operator. But the Colonial breach wasn’t a first for the oil and gas industry, and it certainly won’t be the last. As more of the oil field comes online, it creates additional access points for would-be villains to pounce. What makes the cybersecurity threat unique compared to other obstacles in the industry is that it is likely unsolvable, only manageable.
“This will likely be a forever problem,” said Donald Paul, research professor of engineering at the University of Southern California and former CTO at Chevron. “It’s not like you can do something and fix it all, because ultimately, as the technology changes, as you add more digital systems, more vulnerabilities show up, and then the bad guys figure out how to crack them. It’s an ongoing process.”
Fishbone Stimulation Enhances Tight Carbonate Productivity
Authors: Carpenter Chris 
Published: August 2021

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 202636, “Fishbone Stimulation: A Game Changer for Tight Carbonate Productivity Enhancement—Case Study of First Successful Implementation at ADNOC Onshore Fields,” by R.V. Rachapudi, SPE, S.S. Al-Jaberi, SPE, and M. Al Hashemi, SPE, ADNOC, et al., prepared for the 2020 Abu Dhabi International Petroleum Exhibition and Conference, Abu Dhabi, held virtually 9–12 November. The paper has not been peer reviewed.
The operator’s first successful installation of fishbone stimulation technology was aimed at establishing vertical communication between layers in a tight carbonate reservoir and maximizing the reservoir contact. Furthermore, the advanced stimulation technology connects natural fractures within the reservoir, bypasses near-wellbore damage, and allows the thin sublayers to produce. This technology requires running standard lower-completion tubing with fishbone subs preloaded with 40-ft needles and stimulation with the rig on site.

Introduction
The operator plans to develop tight carbonate reservoirs as part of its production growth strategy. Field Q is a 35×15-km field under development with a phased approach. Phase 1 was planned and production began in 2014. Phase 2 is being developed by drilling wells using the pad concept.
Reservoir A, a tight carbonate formation with low permeability ranging from 1 to 3 md and porosity from 15 to 25%, is part of Phase 2 development. The aver-age thickness of Reservoir A is approximately 90 ft across the field, with seven sublayers. The major challenge of Reservoir A development is poor vertical communication and low permeability. Based on appraisal-well data, the average production rate per well is approximately 200 to 400 BOPD with a wellhead pressure of 200 psi. Therefore, appraisal-well testing confirmed the poor productivity of the wells. In addition, the wells are required to produce to the central facilities located in a Phase 1 area 18 km away from Phase 2. In summary, each Phase 2 well is required to be produced against a back-pressure of 500 to 600 psi.

Fishbone Stimulation Technology
Fishbone stimulation technology is an uncemented-liner rig-deployed completion stimulation system. The liner includes fishbone subs at fixed intervals, and each sub consists of four needles that will connect the sublayers by penetrating into the formation. The typical fishbone completion after installation and jetting the needles in formation is shown in Fig. 1.
The Challenge of Equipoise: Qualitative Interviews Exploring the Views of Health Professionals and Women With Multiple Ipsilateral Breast Cancer in a Surgical Randomised Controlled Trial.
Authors: Ingram Jenny , Beasant Lucy , Benson John , Brunt Adrian Murray , Maxwell Anthony , Harvey James Richard , Greenwood Rosemary , Roberts Nicholas , Williams Norman , Johnson Debbie , Winters Zoe 
Published: August 2021

Abstract
BackgroundA multicentre feasibility trial (MIAMI), comparing outcomes and quality of life of women with multiple ipsilateral breast cancer randomised to therapeutic mammoplasty or mastectomy, was conducted from September 2018 to March 2020. The MIAMI surgical trial aimed to investigate recruitment of sufficient numbers of women. Multidisciplinary teams at 10 breast care centres in the UK identified 190 with MIBC diagnosis; 20 were eligible for trial participation but after being approached only four patients were recruited. A nested qualitative study sought to understand the reasons for this lack of recruitment.MethodsInterviews were conducted from November 2019 to September 2020 with 17 staff from eight hospital-based breast care centres that recruited and attempted to recruit to MIAMI; and seven patients from four centres, comprising all patients who were recruited to the trial and some who declined to take part. Interviews were audio-recorded, anonymised and analysed using thematic methods of building codes into themes and sub-themes using the process of constant comparison.ResultsOverarching themes of 1) influences on equipoise and recruitment and 2) effects of a lack of equipoise were generated. Within these themes health professional themes described the barriers to recruitment as ‘the treatment landscape has changed’; staff preferences and beliefs’ which influenced equipoise and patient advice; and how different the treatments were for patients. Patient themes of ‘altruism and timing of trial approach’; ‘influences from consultants and others’; and ‘diagnostic journey doubts’ all played a part in whether patients agreed to take part in the trial.Conclusions﻿Barriers to recruiting to breast cancer surgical trials can be significant, especially where there are substantial differences between the treatments being offered and a lack of equipoise communicated by healthcare professionals to patients. Patients can become overwhelmed by numerous requests for participation in research trials and inappropriate timing of trial discussions. Alternative study designs to the gold standard randomised control trial for surgical interventions may be required to provide the high-quality evidence on which to base practice.Trial registration numbers: ISRCTN (ISRCTN17987569) registered 20/04/2018, https://www.isrctn.com/ISRCTN17987569; and ClinicalTrials.gov (NCT03514654).
Composition Optimization, High-temperature Stability and Thermal Cycling Performance of Sc-doped Gd2Zr2O7 Thermal Barrier Coatings: Theoretical and Experimental Studies
Authors: Guo Lei , Li Bowen , Cheng Yuxian , Wang Lu 
Published: August 2021

Abstract
Sc was doped into Gd2Zr2O7 for expanding the potential for thermal barrier coating (TBC) applications. According to first-principles calculation, solid solution mechanism of Sc in Gd2Zr2O7 lattice was revealed, i.e., Sc atoms first occupy the lattice interstitial sites followed by substituting for Gd, and the interstitial Sc concentration is less than 11.11 at. %. By considering the mechanical and thermophysical properties comprehensively, the optimum Sc doping content was determined to be 16.67 at. %, and this Sc content was selected to produce TBCs by air plasma spraying with YSZ as a bottom ceramic coating (Gd-Sc/YSZ TBC). After sintering at 1400 ℃ for 100 h, Gd-Sc coatings retain phase and structural stability indicative of excellent sintering resistance. By thermal cycling tests, Gd-Sc TBCs fail due to the low toughness and the interface reaction between Gd-Sc and bond coat, while Gd-Sc/YSZ TBCs exhibit much longer thermal cycling lifetime, and the failure mode is YSZ coating cracking.
An effective step for evaluating of the sexual function: Developing and Standardizing Sexual Intelligence Scale
Authors: Dehkordi Mahnaz Aliakbari , Kharaman Azita , Mohtashami Tayebeh , Karimi Zahra 
Published: August 2021

Abstract
Background: Sexual intelligence is one of the most vital topics in research and clinical fields. Therefore, the existence of a suitable instrument for measuring these structures is an inevitable necessity. This study designed a valid and reliable sexual intelligence scale.Methods: In this instrumental research, 225 students of Payame Noor University were selected by purposeful sampling and answered the questionnaire. A baseline questionnaire with 36 questions was provided to the participants. SPSS software, statistical analysis of factor analysis and correlation coefficient were used for data analysis.Results: In an exploratory factor analysis that was done on 19 materials of this test, results revealed 4 factors. Initial examination in this test showed that 4 important and prominent factors were found after rotation and by considering the sloping line diagram.Conclusion: The present study showed that the designed tool is of sufficient competence and can be used in clinical research and diagnosis.
Methylated Septin 9 Gene is an Important Prognostic Marker in Stage II and Stage III Colorectal Cancer for Evaluating Local Recurrence or Distant Metastasis After Surgery
Authors: Huang Mingliang , He Jiehua , Lai Wei , Liu Lu , Xu Heyang , Zeng Yujie , Lan Qiusheng , Lin Xiangan , Chu Zhonghua 
Published: August 2021

Abstract
Background: Abnormal hypermethylation of the septin 9 gene was an inchoate incident in some cancers. Though latest several researches had paid attention to its value in prognosis, the consequences were not distinctly, especially in colorectal cancer (CRC) with stage II and stage III.Purpose: The aim of this research was to pick up the prognostic value of the methylated septin 9 gene (mSEPT9) in CRC patients, particularly in TNM stage II - III.Methods: Blood samples before surgery were obtained from 144 CRC patients, of which there were 94 with stage II and stage III. mSEPT9 was considered positive when the cycle number of the peak reaction (Ct) was lower than the threshold value (41.0) for two times during three times PCR test. mSEPT9 and other relative factors of prognosis were estimated by survival analysis. The level of septin9 in tissues was tested by immunohistochemical (IHC).Results: Stage II and stage III patients with mSEPT9 positive (mSEPT9+) had a lower disease-free survival (DFS) rate than those with mSEPT9 negative (mSEPT9-) (2-year DFS rates, 52.1% vs 73.9%, P = 0.014). In multivariate regression analysis, mSEPT9 was also an independent predictor of prognosis (HR = 2.741, P = 0.009). The risk of local recurrence or distant metastasis in CRC patients after surgery was mSEPT9+ with stage III, mSEPT9- with stage III/mSEPT9+ with stage II, and mSEPT9- with stage II (P = 0.001), from highest to lowest. In addition, mSEPT9 was strongly associated with TNM staging, tumor immersion depth, distant metastasis, differentiation degree, vascular invasion and microsatellite. When we explored the associations between septin9 protein level revealed by IHC and other elements, recurrence/progression (R = -0.523, P = 0.001), mSEPT9 status (R = -0.451, P = 0.004) and T stage (R = -0.375, P = 0.017) showed significant correlation.Conclusions: Positive mSEPT9 is a poor prognostic marker for CRC patients in stage II and III. It is also a powerful complement to TNM staging in predicting postoperative DFS of CRC patients of stage II and III.
Assessment of Frailty In Elderly Patients Attending A Multidisciplinary Wound Care Center: A Cohort Study.
Authors: Espaulella-Ferrer Mariona , Espaulella-Panicot Joan , Noell-Boix Rosa , Casals-Zorita Marta , Ferrer-Sola Marta , Puigoriol-Juvanteny Emma , Cullell-Dalmau Marta , Otero-Viñas Marta 
Published: August 2021

Abstract
Background: The incidence of frailty and chronic wounds increases with patients’ age. Knowledge of the relationship between frailty and wound healing progress is greatly lacking. Methods: The aim of this study is to characterize the degree of frailty in elderly patients attending a multidisciplinary wound care centers (MWCC). Additionally, we seek to assess the impact of frailty on the wound healing rate and wound healing time. An open cohort study was conducted on 51 consecutive patients aged > 70 years treated for wounds at an MWCC of an intermediate care hospital. The frailty score was determined according to the Frail-VIG index. Data were collected through patient questionnaires at the beginning of the study, and at six months or upon wound healing. Wounds were followed up every two weeks. To analyze the relationship between two variables was used the Chi-square test and Student’s or the ANOVA model. The t-test for paired data was used to analyze the evolution of the frailty index during follow-up.Results: A total of 51 consecutive patients were included (aged 81.1 ± 6.1 years). Frailty prevalence was 74.5% according to the Frail-VIG index (47.1% mildly frail, 19.6% moderately frail, and 7.8% severely frail). Wounds healed in 69.6% of cases at six months. The frailty index (FI) was higher in patients with non-healing wounds in comparison with patients with healing wounds (IF 0.31 ± 0.15 vs IF 0.24 ± 0.11, p=0.043). A strong correlation between FI and wound healing results was observed in patients with non-venous ulcers (FI 0.37 ± 0.13 vs FI 0.27 ± 0.10, p=0.015). However, no correlation was observed in patients with venous ulcers (FI 0.17 ± 0.09 vs FI 0.19 ± 0.09, p=0.637). Wound healing rate is statically significantly higher in non-frail patients (3,26% wound reduction/day, P25-P75 0.8-8.8%/day) in comparison with frail patients (8.9% wound reduction/day, P25-P75 3.34-18.3%/day; p=0.044). Conclusion: Frailty is prevalent in elderly patients treated at an MWCC. Frailty degree is correlated with wound healing results and wound healing time.