bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibroblast growth factor 11 (FGF11) promotes non-small cell lung cancer (NSCLC) progression by regulating hypoxia signaling pathway
Authors: Wu Xiaowei , Li Minjie , Li Ying , Deng Yu , Ke Shun , Li Fan , Wang Yujin , Zhou Shuchang 
Published: August 2021

Abstract
Background
Accumulating evidence highlights the critical roles of fibroblast growth factors (FGFs) in regulating the progression of multiple human cancers, including non-small cell lung cancer (NSCLC). In this study, we investigated the role of FGF11 in the progression of NSCLC.

Methods
Previously published transcriptomic data (GSE75037 and GSE81089) were used to compare FGF11 expression level between NSCLC tumor tissues and adjacent normal tissues. 100 cases of NSCLC tumor tissues and 30 cases of matched adjacent normal tissues were used to validate FGF11 expression at mRNA and protein level by qPCR and immunohistochemistry. Bioinformatics analysis and dual luciferase reporter analysis were performed to confirm the regulatory effect of miR-525-5p on FGF11 expression. CCK-8 assay and transwell migration assay were employed to examine cellular proliferation, migration and invasion. Gene set enrichment analysis (GSEA) was performed to identify the signaling pathway associated with FGF11 expression. Finally, the functional role of FGF11 in NSCLC tumor growth was evaluated by in vivo study.

Results
FGF11 was upregulated in NSCLC tumor tissues and tumor cell lines. High FGF11 expression was associated with a poor prognosis in NSCLC patients. In vitro loss- and gain-of function experiments demonstrated that FGF11 knockdown inhibited, whereas FGF11 overexpression promoted the proliferation, migration and invasion of NSCLC cells. Dual luciferase reporter assay confirmed that FGF11 was downregulated by miR-525-5p, and the effect of FGF11 on cell proliferation, migration and invasion could be interfered by miR-525-5p. GSEA analysis further revealed that FGF11 expression was enriched with genes in hypoxia signaling pathway and the oncogenic function of FGF11 could be suppressed by knocking down HIF-1α in NSCLC cells. Moreover, FGF11 knockdown suppressed NSCLC tumor growth whereas FGF11 overexpression promoted tumor growth in vivo.

Conclusions
Our study showed that FGF11 functions as an oncogene in tumor NSCLC progression. miR-525-5p seems to negatively regulate FGF11 and the oncogenic role of FGF11 is dependent on the upregulation of HIF-1α. Our study suggests that targeting FGF11 and HIF-1α may serve as novel strategies for the treatment of NSCLC.
A translational triage research development tool: standardizing prehospital triage decision-making systems in mass casualty incidents
Authors: Khorram-Manesh Amir , Nordling Johan , Carlström Eric , Goniewicz Krzysztof , Faccincani Roberto , Burkle Frederick M. 
Published: August 2021

Abstract
Background
There is no global consensus on the use of prehospital triage system in mass casualty incidents. The purpose of this study was to evaluate the most commonly used pre-existing prehospital triage systems for the possibility of creating one universal translational triage tool.

Methods
The Rapid Evidence Review consisted of (1) a systematic literature review (2) merging and content analysis of the studies focusing on similarities and differences between systems and (3) development of a universal system.

Results
There were 17 triage systems described in 31 eligible articles out of 797 identified initially. Seven of the systems met the predesignated criteria and were selected for further analysis. The criteria from the final seven systems were compiled, translated and counted for in means of 1/7’s. As a product, a universal system was created of the majority criteria.

Conclusions
This study does not create a new triage system itself but rather identifies the possibility to convert various prehospital triage systems into one by using a triage translational tool. Future research should examine the tool and its different decision-making steps either by using simulations or by experts’ evaluation to ensure its feasibility in terms of speed, continuity, simplicity, sensitivity and specificity, before final evaluation at prehospital level.
Time-dependent effect of 1,6-hexanediol on biomolecular condensates and 3D chromatin organization
Authors: Liu Xinyi , Jiang Shaoshuai , Ma Lin , Qu Jiale , Zhao Longying , Zhu Xing , Ding Junjun 
Published: August 2021

AbstractBackgroundBiomolecular condensates have been implicated in multiple cellular processes. However, the global role played by condensates in 3D chromatin organization remains unclear. At present, 1,6-hexanediol (1,6-HD) is the only available tool to globally disrupt condensates, yet the conditions of 1,6-HD vary considerably between studies and may even trigger apoptosis.ResultsIn this study, we first analyzed the effects of different concentrations and treatment durations of 1,6-HD and found that short-term exposure to 1.5% 1,6-HD dissolved biomolecular condensates whereas long-term exposure caused aberrant aggregation without affecting cell viability. Based on this condition, we drew a time-resolved map of 3D chromatin organization and found that short-term treatment with 1.5% 1,6-HD resulted in reduced long-range interactions, strengthened compartmentalization, homogenized A-A interactions, B-to-A compartment switch and TAD reorganization, whereas longer exposure had the opposite effects. Furthermore, the long-range interactions between condensate-component-enriched regions were markedly weakened following 1,6-HD treatment.ConclusionsIn conclusion, our study finds a proper 1,6-HD condition and provides a resource for exploring the role of biomolecular condensates in 3D chromatin organization.
Microvascular complications and its predictors among type 2 diabetes mellitus patients at Dessie town hospitals, Ethiopia
Authors: Seid Mohammed Abdu , Akalu Yonas , Gela Yibeltal Yismaw , Belsti Yitayeh , Diress Mengistie , Fekadu Sofonias Addis , Dagnew Baye , Getnet Mihret 
Published: August 2021

Abstract
Background
Diabetes mellitus is a serious metabolic disorder which becomes common in middle and low incomes countries since few decades. Microvascular complications include retinopathy, neuropathy and nephropathy all of which can lead to disability, dependency, accelerate their morbidity, and mortality. In Ethiopia, there is paucity data regarding this topic. Hence, this study aimed to assess prevalence of microvascular complications and its predictors among type 2 diabetes mellitus patients.

Methods
Cross-sectional study was conducted from February to March 2020 at Dessie town hospitals. We used simple random sampling to recruit study participants and pre-tested interviewer administered questionnaire to collect the data. Data was entered into Epi-Data 3.1 and exported to SPSS-23 for analysis. Binary logistic regression was done to select potential variables to be adjusted at p ≤ 0.25. After running multivariable regression, variables with a p-value ≤ 0.05 were declared as statistically significant.

Results
Three hundred and thirty-five type 2 DM patients participated in the study, of which 54.6% were males. One hundred and twenty-seven [37.9% (95% CI 32.5%–43.3%)] of diabetes mellitus had at least one microvascular complications. These were retinopathy 24.8%, nephropathy 16.1%, and neuropathy 8.1%. Age 60–87 years (AOR = 2.76, 95% CI 1.02–7.46), duration of diabetes > 5 years (AOR = 4.09, 95% CI 2.40–6.96), mellitus and co-morbid hypertension (AOR = 3.52, 95% CI 2.09–5.95), were statistically significant.

Conclusions
In this study, diabetic microvascular complications are prevalent. Increasing the age of participants, longer duration of diabetes mellitus and co-morbid hypertension were independent predictors. Health workers should give emphasis for diabetes mellitus through early screening and health education, abrupt medication for aged patients with long duration of diabetes mellitus, and hypertension, and also early detection and management of microvascular complication.
Match running performance in Brazilian professional soccer players: comparisons between successful and unsuccessful teams
Authors: Aquino Rodrigo , Gonçalves Luiz Guilherme , Galgaro Marcos , Maria Thiago Santi , Rostaiser Eduardo , Pastor Alejandro , Nobari Hadi , Garcia Gabriel Rodrigues , Moraes-Neto Maxwell Viana , Nakamura Fábio Yuzo 
Published: August 2021

Abstract
Background
This study aimed to compare the match running performance between bottom- and top-ranked teams in professional soccer players over the 2020 season of the Brazilian National 2nd Division League. In addition, this study verified the independent and interactive effects of playing position and contextual factors on running outputs between these teams.

Methods
Forty-eight professional male outfield soccer players participated in this study (top-ranked team, n = 24; bottom-ranked team, n = 24). The distance- and accelerometry-based measures were recorded during 69 matches using a global positioning system (10 Hz) integrated with an accelerometer (400 Hz).

Results
The top-ranked team covered greater total distance [median (interquartile range); 10,330.0 m (1430.0)] and high-acceleration [97.0 m (32.0)] than the bottom-ranked team, in home and away matches [p < 0.05, effect size (ES) = small]. The midfielders of the top-ranked team covered higher total distance, high-speed running (> 18 km h−1), high acceleration (≥ 3 m s−2), high-deceleration (≤ −3 m s−2), and performed more sprints [(> 25 km h−1) compared to midfielders of the bottom-ranked team (p < 0.05, η2 = small-moderate]. The matches against top-level opponents required high values of high-acceleration and number of sprints only for the top-ranked team (p < 0.05, ES = small). Independent analysis showed that match outcome (loss vs. draw vs. win) was not influenced by running performance for both bottom- and top-ranked teams (p > 0.05; η2 = small). However, the top-ranked team covered greater total distance, high-acceleration/deceleration than bottom-ranked team in loss matches (p < 0.05, η2 = small).

Conclusions
These findings should be considered when the coaches and practitioners interpret the match running outputs and when evaluating the effects of training intervention on these performance indicators.
Altered trunk and lower extremity movement coordination after neuromuscular training with and without external focus instruction: a randomized controlled trial
Authors: Sheikhi Bahram , Letafatkar Amir , Thomas Abbey C. , Ford Kevin R. 
Published: August 2021

Abstract
Background
This study sought to determine the effects of a 6-week neuromuscular training (NMT) and NMT plus external focus (NMT plus EF) programs on trunk and lower extremity inter-segmental movement coordination in active individuals at risk of injury.

Methods
Forty-six active male athletes (controls = 15, NMT = 16, NMT plus EF = 15) participated (age = 23.26 ± 2.31 years) in this controlled, laboratory study. Three-dimensional kinematics were collected during a drop vertical jump (DVJ). A continuous relative phase (CRP) analysis quantified inter-segmental coordination of the: (1) thigh (flexion/extension)—shank (flexion/extension), (2) thigh (abduction/adduction)—shank (flexion/extension), (3) thigh (abduction/adduction)—trunk (flexion/extension), and (4) trunk (flexion/extension)—pelvis (posterior tilt/anterior tilt). Analysis of covariance compared biomechanical data between groups.

Results
After 6 weeks, inter-segmental coordination patterns were significantly different between the NMT and NMT plus EF groups (p < 0.05). No significant differences were observed in CRP for trunk-pelvis coupling comparing between NMT and NMT plus EF groups (p = 0.134), while significant differences were observed CRP angle of the thigh-shank, thigh-trunk couplings (p < 0.05).

Conclusions
Trunk and lower extremity movement coordination were more in-phase during DVJ in the NMT plus EF compared to NMT in active individuals at risk of anterior cruciate ligament injury.
Trial registration: The protocol was prospectively registered at UMIN_RCT website with ID number: UMIN000035050, Date of provisional registration 2018/11/27.
Multiple site neural tube defects at Zewuditu Memorial Hospital, Addis Ababa, Ethiopia: a case report
Authors: Shiferaw Mestet Yibeltal , Awedew Atalel Fentahun , T/Mariam Tsegazeab Laeke , Aklilu Abenezer Tirsit , Akililu Yemisirach Bizuneh , Andualem Aemiro Mazengia 
Published: August 2021

Abstract
Background
Neural tube defects are common group of central nervous system anomalies of complex etiology and major public health importance worldwide. The occurrence of multiple neural tube defects, however, is an extremely rare event and has never been reported in Ethiopia so far. This study gives an insight into how the embryogenesis, management, and postoperative complications of multiple neural tube defects differ from the ordinary single neural tube defects on the basis of up-to-date existing literature.

Case presentation
This paper highlights a case of an 8 days old female black race Ethiopian neonate who was brought by her mother with the chief complaint of lower back and lower neck swelling since birth. The findings were a 5 × 4 × 5 cm sized ulcerated placode at the mid-lumbosacral area and a 1.5 × 1.5 × 1 cm sized fluctuant, nontender, transilluminating mass with overlying unruptured defect dysplastic skin at the cervicothoracic junction. With a diagnosis of multiple neural tube defects secondary to unruptured cervicothoracic meningocele and ruptured lumbosacral myelomeningocele, single-stage repair of the defects was done with good outcome.

Conclusion
There is insufficient evidence as to the exact mechanism of development of multiple neural tube defects. Similarly, whether patients with multiple neural tube defects had increased risk of post repair hydrocephalus compared with patients who have single neural tube defect is unknown. Hence, more research on the embryogenesis, management, and long-term outcome of multiple neural tube defects in particular and single neural tube defects in general should be done to better help patients with this costly and crippling problem. Lastly, the practice of folic acid supplementation is very low in resource-limited countries such as Ethiopia and, hence, should be improved.
New temperature and oxygen fugacity data of Martian nakhlite from Northwest Africa (NWA) 5790 and implications for shallow sulphur degassing
Authors: Wang Zilong , Tian Wei , Di Yankun 
Published: August 2021

AbstractNewly analysed titanomagnetite–ilmenite (Tim–Ilm) intergrowths from Martian nakhlite meteorite Northwest Africa (NWA) 5790 yielded crystallisation temperature up to 1032 °C and oxygen fugacity (fO2) up to ΔQFM + 1.6, notably higher than previous estimates for nakhlite magmas (temperature < 950 °C, fO2 = ΔQFM − 0.5 to ΔQFM + 1). To interpret how the magma was reduced from ΔQFM − 0.5 to ΔQFM + 1.6, we used D-Compress to model the sulphur degassing process within a single thick lava pile. For fO2 to significantly decrease in this extended range, a sulphur-rich (S content 4000–7000 ppm) Martian lava flow had to degas all the sulphur species at a certain final degassing pressure, which was 2–4 bar for NWA 988 and Lafayette and < 0.7 bar for Y-000593 and Nakhla. These final degassing pressure data are in good agreement with the Martian nakhlite burial depth estimated by other petrological and geochemical methods. These estimates are also comparable with the excavation depth of ~ 40 m based on the small (6.5 km in diameter) impact crater over the Elysium lava plain. The fO2-controlled sulphur degassing pressure may constitute a method for estimating the burial depth of sulphur-rich lava flows on Mars.
Faults resembling channel-like features
Authors: Bhatnagar Paritosh , Karam Pierre , Verma Sumit 
Published: August 2021

We analyzed a synthetic transfer zone and its associated fault planes and relay ramp in Penobscot, a potential offshore field in the Scotian Basin. Transfer zones are structural areas where one fault dies out and another fault begins, forming a relay ramp in the middle. They can be categorized as divergent, convergent, and synthetic transfer zones depending on the relative location and dipping directions of the faults. These zones not only play an important role in fluid migration but also help interpreters delineate secondary features such as fractures, splay shears, and Riedel faults. Commonly, those faults would branch into smaller splays and the relay ramp can get “breached” with connecting faults with the increase of slip. The study area in the Scotian Basin is characterized by two major listric normal faults dipping in the same direction giving rise to a synthetic transfer zone. These faults are clearly visible on seismic attributes, including curvature and coherence slices extracted along the top of the Cretaceous Petrel Formation. However, when analyzing the seismic attributes along the overlying Wyandot Formation’s top, we observe channel-like features, which run parallel as well as at an angle to these faults. However, when we performed further analysis using seismic amplitude’s vertical slices, interpreted horizons, and seismic attributes, we found that these features are not channels. We divided the features into two types: The first type is parallel to the main faults and can be associated with the grabens formed by synthetic and antithetic secondary faults (northeast–southwest); the second type is related to the polygonal faulting associated with differential compaction and gravitational loading of the Wyandot Chalk Formation. Apart from the two lineations, there are north-northeast–south-southwest-oriented lineations, which are an impression of basement faulting, and north-northwest–south-southeast-oriented lineations representing the acquisition footprint. Geological feature: Synthetic and antithetic faults in a synthetic transfer zone Seismic appearance: Channel-like feature on seismic attribute horizon slices Alternative interpretations: Channels Features with similar appearance: Steep slope channels Formation: Wyandot Age: Late Cretaceous Location: Penobscot, Nova Scotia, Canada Seismic data: Open-source SEG Analysis tools: Coherence and curvature attributes
Sex Differences in Cancer Genomes: Much Learned, More Unknown
Authors: Zhu Chenghao , Boutros Paul C 
Published: August 2021

Abstract
Cancer is a leading cause of death worldwide. Sex influences cancer in a bewildering variety of ways. In some cancer types, it affects prevalence; in others, genomic profiles, response to treatment, or mortality. In some, sex seems to have little or no influence. How and when sex influences cancer initiation and progression remain a critical gap in our understanding of cancer, with direct relevance to precision medicine. Here, we note several factors that complicate our understanding of sex differences: representativeness of large cohorts, confounding with features such as ancestry, age, obesity, and variability in clinical presentation. We summarize the key resources available to study molecular sex differences and suggest some likely directions for improving our understanding of how patient sex influences cancer behavior.
Panoramic depth estimation via supervised and unsupervised learning in indoor scenes
Authors: Zhou Keyang , Yang Kailun , Wang Kaiwei 
Published: August 2021

Depth estimation, as a necessary clue to convert 2D images into the 3D
space, has been applied in many machine vision areas. However, to
achieve an entire surrounding 360° geometric sensing, traditional
stereo matching algorithms for depth estimation are limited due to
large noise, low accuracy, and strict requirements for multi-camera
calibration. In this work, for a unified surrounding perception, we
introduce panoramic images to obtain a larger field of view. We extend
PADENet [IEEE 23rd
International Conference on Intelligent Transportation
Systems, (2020), pp. 1–610.1109/ITSC45102.2020.9294206], which
first appeared in our previous conference work for outdoor scene
understanding, to perform panoramic monocular depth estimation with a
focus for indoor scenes. At the same time, we improve the training
process of the neural network adapted to the characteristics of
panoramic images. In addition, we fuse the traditional stereo matching
algorithm with deep learning methods and further improve the accuracy
of depth predictions. With a comprehensive variety of experiments,
this research demonstrates the effectiveness of our schemes aiming for
indoor scene perception.
Leptospirosis as a cause of fever associated with jaundice in the Democratic Republic of the Congo
Authors: Mukadi Kakoni Patrick , Munyeku Bazitama Yannick , Nepomuceno Jean Raphael , Pukuta-Simbu Elisabeth , Kawhata Mawika Francois , Kashitu Mujinga Gracia , Palla Luigi , Ahuka-Mundeke Steve , Muyembe Tamfum Jean-Jacques , Koizumi Nobuo , Kubo Yoshinao , Ariyoshi Koya , Smith Chris 
Published: August 2021

Background
Fever with jaundice is a common symptom of some infectious diseases. In public health surveillance within the Democratic Republic of the Congo (DRC), yellow fever is the only recognized cause of fever with jaundice. However, only 5% of the surveillance cases are positive for yellow fever and thus indicate the involvement of other pathogens. Leptospira spp. are the causative agents of leptospirosis, a widespread bacterial zoonosis, a known cause of fever with jaundice. This study aimed to determine the seropositivity of anti-Leptospira antibodies among suspected yellow fever cases and map the geographical distribution of possible leptospirosis in the DRC.

Methods
We conducted a retrospective study using 1,300 samples from yellow fever surveillance in the DRC from January 2017 to December 2018. Serum samples were screened for the presence of IgM against Leptospira spp. by a whole cell-based IgM ELISA (Patoc-IgM ELISA) at the Institut National de Recherche Biomedicale in Kinshasa (INRB) according to World Health Organization (WHO) guidance. Exploratory univariable and multivariable logistic regression analyses were undertaken to assess associations between socio-demographic factors and the presence of Leptospira IgM.

Results
Of the 1,300 serum samples screened, 88 (7%) showed evidence of IgM against Leptospira spp. Most positive cases (34%) were young adult males in the 20–29-year group. There were statistically significant associations between having Leptospira IgM antibodies, age, sex, and living area. Observed positive cases were mostly located in urban settings, and the majority lived in the province of Kinshasa. There was a statistically significant association between seasonality and IgM Leptospira spp. positivity amongst those living in Kinshasa, where most of the positive cases occurred during the rainy season.

Conclusions
This study showed that leptospirosis is likely an overlooked cause of unexplained cases of fever with jaundice in the DRC and highlights the need to consider leptospirosis in the differential diagnosis of fever with jaundice, particularly in young adult males. Further studies are needed to identify animal reservoirs, associated risk factors, and the burden of human leptospirosis in the DRC.