bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioactive compounds, antioxidant activity and fruit quality evaluation of eleven blood orange cultivars
Authors: Legua Pilar , Modica Giulia , Porras Ignacio , Conesa Agustín , Continella Alberto 
Published: November 2021

AbstractBACKGROUNDBlood oranges are grown increasingly in Europe for fresh consumption because of their special taste and excellent nutraceutical properties that confer the status of a functional food. The health benefits are associated with the range of additional bioactive compounds that they contain with respect to blonde oranges.RESULTSWe analysed the physicochemical properties and the levels of organic acids, sugars and antioxidants in 11 blood orange cultivars representing the most representative cultivars of blood oranges widespread in the Mediterranean basin. In particular, we examined the levels of phenols, flavonoids and anthocyanins present in these cultivars at harvest maturity. The physicochemical, antioxidant and colour properties differ significantly among these cultivars. The deepest red peel and juice was found in Sanguinelli, followed by Tarocco Rosso and Moro. High‐performance liquid chromatography with refractive index detector analysis revealed sucrose as the main sugar in all these cultivars, followed by fructose and glucose. Citric acid was the dominant organic acid, followed by malic acid and ascorbic acid. Moro showed the greatest levels of antioxidant activity. Regarding the phenolic composition, we found p‐coumaric acid to be the main hydroxycinnamic acid in all cultivars, with maximum amounts in Moro and Sanguinelli. The highest amounts of cyanidin‐3‐O‐glucoside and cyanidin‐3‐(6′′‐malonyl)‐glucoside were found in Moro, for which the juice was of the deepest red colour.CONCLUSIONThe phenolic composition and antioxidant activity of the 11 cultivars was assessed. The results showed that Moro was the cultivar with the highest content of polyphenols and levels of antioxidant activity, followed by Sanguinelli. © 2021 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Feasibility of pXRF to evaluate chosen heavy metals in soil highly influenced by municipal waste disposal—A monitoring study of a former sewage farm
Authors: Sut‐Lohmann Magdalena , Ramezany Shaghayegh , Kästner Friederike , Raab Thomas 
Published: November 2021

AbstractSewage disposal onto agricultural land may result in the high accumulation of organic wastes, which questions the applicability of typical elemental analysis used for the soil components. To monitor the contamination status of agricultural soils at a former sedimentation basin, after the long‐term cessation of wastewater irrigation, 110 locations (15–20 cm depth) and 4 boreholes (up to 100 cm depth) were sampled to determine pH, loss on ignition, and concentration of Ni, Cu, Pb, Zn, and Cr. Additionally, the applicability of portable X‐ray fluorescence (pXRF) for the soil samples highly influenced by the organic wastes was evaluated. The study revealed the presence of a relatively homogenous sewage waste layer (depth of 20 cm), characterized by slightly acidic to neutral pH (6.3–7.5), high organic matter (OM) accumulation (up to 49%), and elevated concentration (mg kg −1) ranges between: Pb (5–321), Cu (31–2828), Ni (10–193), Cr (14–966), and Zn (76–6639). The pXRF analysis revealed metal concentration increase in mineral samples (up to 50%). The regression models and correction factors demonstrated high correlation and significance of pXRF measurement with response to increasing OM content, with the lowest r 2 = 0.86 obtained for Ni. Correlation of pXRF and AES measurement illustrated element‐dependent response for soils high in organics. Zn, Cu, and Cr pXRF analysis led to a slight underestimation in lower values, but overall good correlations (0.87; 0.89; and 0.88 respectively). Pb and Ni pXRF measurement revealed higher deviation from the reference in both lower and higher concentrations (0.74 and 0.70, respectively).
Chemical, physical‐temporal and spatial changes in 25‐year‐old mine soils in Southeast Ohio
Authors: Demyan Michael Scott , Smeck Neil 
Published: November 2021

AbstractReclaimed surface coal mines afford an opportunity to study initial pedogenic processes. This study sought to determine pedogenic processes active in a topsoiled* surface mine over 25 years. Soils were taken at 108 points from three grids in 1979 (1 year) and 2004 (25 years post‐reclamation) across a 20 ha watershed. The upper darkened portion of the replaced soil (^A1, ca. 0–5 cm), lower portion of the replaced soil (^A2, ca. 5–15 cm), and spoil (^2C) were sampled. Exchangeable Ca2+ increased from 4.3 cmolc kg−1 in 1979 to 8.2 cmolc kg−1 in 2004, and exchangeable Mg2+ increased from 2.5 to 3.3 cmolc kg−1. Soil organic carbon (SOC) increased from 0.59% to 4.05% providing evidence for humification and cycling of basic cations. SOC increases and structural development decreased bulk densities from 1.70 to 0.99 g cm−3 in the ^A1 and 1.70 to 1.24 g cm−3 in the ^A2. pH decreased in all horizons. In ^2C horizons, total sulfur decreased from 0.39% to 0.13% and electrical conductivity 3.34 dS m−1 to 1.01 dS m−1, indicating probable pyrite oxidation and salt leaching. Soils classified as Anthroportic/Anthrodensic Udorthents, as three representative pedons lacked cambic horizons. Mine soil variograms indicated higher spatial dependency in ^A1 and ^A2 horizons in 2004 than 1979 (decreasing nugget: sill ratios), whereas ^2C horizons had lower spatial dependencies in 2004. This suggests that surface horizons are more influenced by soil forming factors than spoil, which is more influenced by 'random' conditions of reclamation and not in equilibrium.
Flexible and Ultrahigh Through‐Plane Thermally‐Conductive Polyethylene/Boron Nitride Nanocomposite Films
Authors: Zhang Ri‐Chao , Huang Zirui , Zhong Meiling , Ji Dehui , Lu Ai , Zhang Quanchao , Lin Yuanfei , Joseph Paul , Zhang Jiali , Sun Dan 
Published: November 2021

AbstractPolymers with relatively higher thermal conductivity are in great demand for many advanced functional applications that often require thermally conductive as well as flexible materials. However, enhancing the thermal conductivity of polymers, while maintaining their mechanical properties, is still a formidable challenge. Here it is reported on the successful fabrication of polyethylene (PE)/boron nitride nanoplate (BNNP) nanocomposite films, with excellent flexibility and ultrahigh through‐plane thermal conductivity, by a uniaxially hot‐stretching process. Results from this study show that the nanocomposite films with ϕv = 6.7 vol% BNNPs, under low stretching ratio (Λ = 5), exhibit a through‐plane thermal conductivity of ≈14.54 W m−1 K−1, about 44.4 times higher than the corresponding bulk value for PE (0.32 W m−1 K−1), while also having improved the Young's modulus of elasticity. The theoretical analysis also shows that such a dramatic enhancement can be attributed to the formation of a 3D continuous network structure within the nanocomposite films. Thus, these flexible films offer possibilities as passive heat exchange matrices in various advanced applications that often require the materials with higher flexibility, lighter weight, easy/scalable processing attributes, and with a higher thermal conductivity.
MCDM applications in logistics performance evaluation: A literature review
Authors: Chejarla Kalyana C. , Vaidya Omkarprasad S. , Kumar Sushil 
Published: November 2021

AbstractThis paper presents a literature review of performance evaluation of logistics, and the use of multi‐criteria decision‐making methods (MCDM) in this area. For this purpose, we covered more than 120 research articles published from 2010 to 2019. The study identifies popular research methodologies, commonly used MCDM methods and 13 research themes that are likely to continue into the coming decade. The study highlights future research opportunities in each of the identified trends. The review comprehensively covers the descriptive and analytical papers providing a 360‐degree view of the developments in the area.
Re‐Analysis of the STEADY‐PD II Trial—Evidence for Slowing the Progression of Parkinson's Disease
Authors: Surmeier D. James , Nguyen Jack T. , Lancki Nicola , Venuto Charles S. , Oakes David , Simuni Tanya , Wyse Richard K. 
Published: November 2021

ABSTRACTBackgroundRecent examination of the STEADY‐PD III isradipine clinical trial data concluded that early‐stage Parkinson's disease (PD) participants who had longer exposure to isradipine had a significant delay in their need for symptomatic medication, as well as a lower medication burden at the end of the trial. These findings suggest that greater exposure to isradipine might slow disease progression.ObjectivesTo test this hypothesis, the data from the STEADY‐PD II isradipine clinical trial, in which an extended‐release (ER) formulation of the drug was used, was re‐examined.MethodsThe re‐analysis of the STEADY‐PD II data was restricted to participants assigned placebo or tolerable isradipine treatment (10 mg isradipine/day or less). The effect of isradipine treatment was assessed by Unified Parkinson's Disease Rating Scale (UPDRS) at the end of the 52‐week trial, rather than by last observation carried forward at the beginning of symptomatic therapy.ResultsParticipant cohorts were well‐matched for baseline disability, initial disease progression, and time to initiation of symptomatic therapy. Participants given 10 mg/day ER isradipine had significantly smaller total and part 3 UPDRS scores at the end of the trial than did the placebo cohort. Post hoc adjustment for symptomatic therapy diminished the statistical significance of these differences. In those participants not taking a monoamine oxidase B inhibitor, the progression in UPDRS scores also was significantly reduced.ConclusionsThese results are consistent with the recent secondary analysis of the STEADY‐PD III clinical trial—suggesting that clinically attainable brain exposure to isradipine may slow early‐stage PD progression. © 2021 International Parkinson and Movement Disorder Society
Effectiveness of nurse‐led counselling and education on self‐efficacy of patients with acute coronary syndrome: A randomized controlled trial
Authors: Bagheri Hossein , Shakeri Sara , Nazari Ali‐Mohammad , Goli Shahrbanoo , Khajeh Mahboobeh , Mardani Abbas , Vlaisavljevic Zeljko 
Published: November 2021

AbstractAimAdherence to lifestyle recommendations, medical regimens and cardiac rehabilitation is poor among patients with acute coronary syndrome. The aim of this study was to examine the effect of nurse‐led counselling and education using a person‐centred care approach on short‐term cardiac self‐efficacy in patients with acute coronary syndrome.DesignA parallel, two‐armed, randomized controlled trial was conducted.MethodsOne hundred twenty patients who were hospitalized with diagnosis of acute coronary syndrome were selected and randomly assigned into intervention (n = 60) or control (n = 60) groups. In the intervention group, in addition to routine care, the nurse‐led counselling and education programme included two face‐to‐face sessions, two telephone counselling and education sessions, using the person‐centred care approach. Participants in the control group received only routine care. Data were collected using the cardiac self‐efficacy scale before the intervention and 1 month after discharge.ResultsAfter the intervention, we found that cardiac self‐efficacy, including the perceived self‐efficacy to control symptoms and maintain function, was statistically significantly higher in the intervention group than the control group.
Graphene oxide/chitosan nano‐coating with ultrafast fire‐alarm response and flame‐retardant property
Authors: Yang Fangzhou , Yuan Bihe , Wang Yong , Chen Xianfeng , Wang Liancong , Zhang Hongming 
Published: November 2021

AbstractUsing layer‐by‐layer self‐assembly technology, an intelligent nano‐coating was constructed on melamine foam (MF) by electrostatic interactions between chitosan (CS) molecules and graphene oxide (GO) nano‐sheets. According to the principle that GO is quickly reduced to reduced GO under high temperature, a fast fire‐warning network can be constructed. Due to the protective effect of nano‐coating constructed on MF, the thermal stability and flame retardancy of melamine composite foams are improved. As the nano‐coating self‐assembly layer increases to 20, its flame‐response time is only 3 s, and the continuous alarm time is as high as 1280 s. These indicate that the prepared GO‐CS composite foam possesses excellent flame retardancy and super‐fast fire response. This study provides a novel idea for the application of bio‐based nano‐coating in the fire early response and warning.
A comprehensive review on performance and machinability of plant fiber polymer composites
Authors: Mohit Hemath , Mavinkere Rangappa Sanjay , Siengchin Suchart , Gorbatyuk Sergey , Manimaran P. , Alka Kumari C. , Khan Anish , Doddamani Mrityunjay 
Published: November 2021

AbstractIn recent years, the revolutionary utilization of plant fibers in polymer laminates significantly influenced environmental effects. Presently, there is progression attention in advancing bio‐based materials by acquiring plant fibers from lignocellulosic components for different applications like non‐structural, structural laminates, automobile components, ballistics, flooring, household utensils, and aerospace parts. These bio‐based, eco‐friendly components have been recognized as next‐generation contestants for higher‐efficacy, sustainable, cheap, environmentally friendly, and lightweight composites. Different kinds of synthetic and natural biopolymers and bio‐based nanoparticles have been applied to produce sustainable materials. Bio‐based polymer composites manifest unique characteristics of both eco‐reinforcement and sustainable resin. This review comprehensively communicates the general characteristics and principles of nanoparticles, polymers, and their respective composites. In addition to the machining characteristics, challenges and future perspectives of the polymer composites have also been reviewed.
Development of thermo‐regulating fabrics with enhanced heat dissipation via graphene‐modified n‐octadecane microcapsules
Authors: Sezer Hicyilmaz Ayse , Teke Sengul , Islek Cin Zeynep , Celik Bedeloglu Ayse 
Published: November 2021

AbstractPhase change materials (PCMs) are of great importance in thermal regulation applications, but low thermal conductivity is the most critical disadvantage of these materials. Especially in the textile field, while there are many studies on the production of PCM‐coated fabrics, studies on improving heat dissipation are quite limited. Therefore, in this study, first, n‐octadecane was encapsulated with melamine formaldehyde shell modified with graphene as a thermal conductivity enhancer, and then, synthesized PCM microcapsules were coated on polyester fabrics. Chemical, morphological, thermal properties, as well as phase change behavior of microcapsules and coated fabrics were analyzed. The thermal conductivity of the PCM microcapsule‐coated PET fabrics was increased by 31% with the addition of very low amount of graphene (0.1%).
Discovery of antimicrobial agent targeting tryptophan synthase
Authors: Bosken Yuliana K. , Ai Rizi , Hilario Eduardo , Ghosh Rittik K. , Dunn Michael F. , Kan Shih‐Hsin , Niks Dimitri , Zhou Huanbin , Ma Wenbo , Mueller Leonard J. , Fan Li , Chang Chia‐En A. 
Published: November 2021

AbstractAntibiotic resistance is a continually growing challenge in the treatment of various bacterial infections worldwide. New drugs and new drug targets are necessary to curb the threat of infectious diseases caused by multidrug‐resistant pathogens. The tryptophan biosynthesis pathway is essential for bacterial growth but is absent in higher animals and humans. Drugs that can inhibit the bacterial biosynthesis of tryptophan offer a new class of antibiotics. In this work, we combined a structure‐based strategy using in silico docking screening and molecular dynamics (MD) simulations to identify compounds targeting the α subunit of tryptophan synthase with experimental methods involving the whole‐cell minimum inhibitory concentration (MIC) test, solution state NMR, and crystallography to confirm the inhibition of L‐tryptophan biosynthesis. Screening 1,800 compounds from the National Cancer Institute Diversity Set I against α subunit revealed 28 compounds for experimental validation; four of the 28 hit compounds showed promising activity in MIC testing. We performed solution state NMR experiments to demonstrate that a one successful inhibitor, 3‐amino‐3‐imino‐2‐phenyldiazenylpropanamide (Compound 1) binds to the α subunit. We also report a crystal structure of Salmonella enterica serotype Typhimurium tryptophan synthase in complex with Compound 1 which revealed a binding site at the αβ interface of the dimeric enzyme. MD simulations were carried out to examine two binding sites for the compound. Our results show that this small molecule inhibitor could be a promising lead for future drug development.
Effect of Melissa officinalis on systolic and diastolic blood pressures in essential hypertension: A double‐blind crossover clinical trial
Authors: Shekarriz Zahra , Shorofi Seyed Afshin , Nabati Maryam , Shabankhani Bizhan , Yousefi Seyde Sedighe 
Published: November 2021

For a long time, Melissa officinalis (M. officinalis) has been used to treat cardiovascular diseases. Therefore, this study aimed at evaluating the effects of M. officinalis on systolic and diastolic blood pressures in hypertensive patients. We conducted a double‐blind, controlled, randomized crossover clinical trial on 49 patients who received either M. officinalis capsules (400 mg/d; n = 23) or the placebo (n = 26) three times per day for a 4‐week period. After a 2‐week washout period, the M. officinalis group received placebo and the other group received M. officinalis for another 4‐week period. The systolic and diastolic blood pressures were measured once at baseline and then every 2 weeks for 10 weeks. The statistical analysis of the obtained data revealed that the chronology of the consumption of M. officinalis and placebo had no effect on the systolic and diastolic blood pressures in these two studied groups. Moreover, it was found that systolic and diastolic blood pressures significantly decreased after the consumption of M. officinalis, compared to placebo. Systolic and diastolic blood pressures in group A at the beginning of the study were 152.30 ± 5.312 mmHg and 95.52 ± 1.988 mmHg, respectively, and, after the first phase (drug use), reached 129.88 ± 9.009 mmHg and 80.13 ± 5.488 mmHg, respectively. Systolic and diastolic blood pressures in group B at the beginning of the study was 152.26 ± 5.640 mmHg and 94.44 ± 2.607 mmHg, respectively, and after the second phase (drug use), reached 131.77 ± 8.091 mmHg and 81.46 ± 7.426 mmHg, (p = .005), respectively. Also, no significant side effects were observed during the study. According to the results, M. officinalis can reduce systolic and diastolic blood pressures of the patients with essential hypertension.
The use of npx$np_{x}$‐type attribute charts to monitor the variance
Authors: Silva Leandro Alves da , Ho Linda Lee , Quinino Roberto Costa 
Published: November 2021

AbstractFirst, the ‐type attribute control charts have been proposed to monitor the process mean. The main contribution of this paper is to show the good performances of the “pure ” (shortly ) and “improved ” (shortly ) attribute charts to monitor the variance. The results confirmed that they are also good alternatives to control chart. To have an equal performance (in terms of speed to detect abnormal cases), the sample size needed for these charts is slightly higher than those practiced for an control chart. This is an advantage since an attribute inspection is faster and cheaper as no measurements on the examined units are taken (mainly if we are dealing with destructive experiments). A numerical example illustrates our proposal.
Potential energy surface of the thiophene pentamer and non‐covalent interactions
Authors: Malloum Alhadji , Conradie Jeanet 
Published: November 2021

AbstractTheoretical understanding of thiophene clusters is very important for molecular understanding of thiophene as solvent and for determining the thermodynamics properties of the solvent. However, no investigations on thiophene clusters have been reported previously in the literature. We have performed in this work an ab initio computational study to understand the interactions taking place in thiophene clusters using the thiophene pentamer. We started by generating possible structures using classical molecular dynamics followed by full optimization at the ab initio MP2/aug‐cc‐pVDZ level of theory. Relative energies and temperature‐dependent isomer distribution of the investigated structures have been reported. Finally, we have performed a quantum theory of atoms in molecule (QTAIM) analysis to identify all non‐covalent bondings that are responsible for the stability of the structures of the thiophene pentamer. The results show that six different types of non‐covalent interactions could be found in thiophene pentamer depending on the structure.
Robust practical output regulation of rational nonlinear systems via numerical approximations to the regulator equations
Authors: Castro Rafael S. , Flores Jeferson V. , Salton Aurélio. T. 
Published: November 2021

AbstractThis article presents a systematic framework able to synthesize error‐ and state‐feedback internal model controllers for the robust practical output regulation of rational nonlinear plants subject to linear exosystems. In order to approximate the system zero‐error steady‐state condition, we consider the use of polynomial mappings with respect to a set of relaxed regulator equations. This methodology allows the implementation of simplified internal models, which is useful to reduce the controller order and also to deal with cases where an exact internal model immersion is unknown. By using a differential‐algebraic representation, our method can be systematically applied to any plant with rational dynamics, including those that cannot be expressed by triangular forms, such as illustrated in the examples. The closed‐loop stabilization problem is carried out in the form of convex optimization problems subject to linear matrix inequality conditions, allowing us to provide rigorous guarantees such as the ultimate boundedness of the output error norm and the exponential convergence of the system trajectories within a minimum decay‐rate.
9,10‐Phenanthrenedione‐Catalyzed, Visible‐Light‐Promoted Radical Intramolecular Cyclization of N‐Biarylglycine Esters: One‐Pot synthesis of Phenanthridine‐6‐Carboxylates
Authors: Natarajan Palani , Chuskit Deachen , Priya  , Manjeet  
Published: November 2021

AbstractA visible‐light photoredox cyclization of a series of N‐biarylglycine esters to phenanthridine‐6‐carboxylates using 9,10‐phenanthrenedione (PQ) as a catalyst, white LEDs (7 W) as irradiation source and oxygen from air as a terminal oxidant is described. Also, for the reaction, a feasible mechanism is proposed. The N‐biarylglycine esters are converted into radical intermediates by the action of an excited‐state catalyst (PQ*), which are subsequently subjected to intramolecular cyclization followed by dehydrogenation reactions in one‐pot to afford desired products in high yield. Use of inexpensive catalyst, short reaction time and in situ generation of N‐biarylglycine esters are some of the important advantages of present methodology while compared to rose bengal‐photocatalysted protocol already reported by us.