bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Support and Depressive Symptoms Among Men and Women With Same-Sex Experiences in Later Life
Authors: Saunders R Kyle , Carr Dawn C 
Published: December 2021

AbstractBackground and ObjectivesSocial support is a vital psychological health resource for well-being in later life. However, research on the associations of social support has largely excluded sexual minorities. This study compares the association between sources of social support and depressive symptoms across groups of older heterosexual and sexual minority men and women. Sexual minority status herein is based on self-reported sexual histories of having same-sex and opposite-sex only experiences (SSE and OSO).Research Design and MethodsBased on a pooled cross-sectional data set drawn from 3 waves of the National Social Life, Health, and Aging Project, we used ordinary least squares regression and moderation tests to evaluate how 3 sources of social support—partner, family, friend—are related to depressive symptoms for SSE and OSO men and women.ResultsResults show OSO men and women both had significant negative associations between depressive symptoms and social support regardless of the source. SSE women, in contrast, only have a significant association between high levels of friend support, and SSE men only show significant effects in relation to high levels of partner support.Discussion and ImplicationsThese results suggest the effects of social support on psychological health are significantly constrained/circumscribed for sexual minority men and women. Interventions designed to decrease symptoms of depression in older sexual minorities through social support are discussed.
Current laboratory protocols for detecting fish species with environmental DNA optimize sensitivity and reproducibility, especially for more abundant populations
Authors: Stoeckle Mark Y , Adolf Jason , Ausubel Jesse H , Charlop-Powers Zach , Dunton Keith J , Hinks Greg 
Published: December 2021

AbstractAnalysing environmental DNA (eDNA) in seawater can aid in monitoring marine fish populations. However, the extent to which current methods optimize fish eDNA detection from water samples is unknown. Here, we test modifications to laboratory components of an eDNA metabarcoding protocol targeting marine finfish. As compared to baseline methods, amplifying a smaller proportion of extracted DNA yielded fewer species, and, conversely, amplifying a larger proportion identified more taxa. Higher-read species were amplified more reproducibly and with less variation in read number than were lower-read species. Among pooled samples, 20-fold deeper sequencing recovered one additional fish species out of a total of 63 species. No benefit was observed with additional PCR cycles, alternative primer concentrations, or fish-selective primers. Experiments using an exogenous DNA standard to assess absolute eDNA concentration suggested that, for a given proportion of a DNA sample, current laboratory methods for metabarcoding marine fish eDNA are near to maximally sensitive. Our results support the unofficial standard collection volume of one liter for eDNA assessment of commonly encountered marine fish species. We conclude that eDNA rarity poses the main challenge to current methods.
A review of partial information in additive multicriteria methods
Authors: Da Silva Lucas Borges Leal , Frej Eduarda Asfora , De Almeida Adiel Teixeira , Ferreira Rodrigo José Pires , Morais Danielle Costa 
Published: December 2021

Abstract
The relevance of multiple criteria decision-making/aiding is reinforced by the prominence of these methods in a wide range of applications. Whether by solving problems with a single decision-maker (DM) or a group of DMs, additive modelling, based on value or utility functions, is the most traditional. However, applying this kind of method raises a critical issue: the difficulty in eliciting DM’s preferences and recommending a decision. Actually, it is a hard task for the DM to provide complete information regarding their preferences, because the DM may not be able to provide such information in the detailed way required, or even they may not be willing to do so. From this perspective, the emergence and growth of partial (incomplete or imprecise) information-based methods is indicative that these are a useful way of guiding decision-making as they require less cognitive input from a DM. Thus, this paper systematically reviews the literature on multicriteria decision methods that deal with partial information, focusing on the Multi-Attribute Value/Utility Theory context. Strategic research questions guide a bibliometric and content analysis of 105 peer-reviewed papers selected from the Web of Science (Main Collection). An integrated analysis of the results provides scholars, researchers and other professionals with a deeper comprehension of methodological advances and respective contributions, and of the main challenges and trends in this field of knowledge. Our analysis aims to show that when these methods are applied more reliable decision-making can be achieved.
On Locally Conformally Kähler Threefolds with Algebraic Dimension Two
Authors: Angella Daniele , Parton Maurizio , Vuletescu Victor 
Published: December 2021

AbstractThe paper is part of an attempt of understanding non-Kähler threefolds. We start by looking at compact complex non-Kähler threefolds with algebraic dimension two and admitting lcK metrics. Under certain assumptions, we prove that they are blown-up quasi-bundles over a projective surface.
Quantitating and assessing interoperability between electronic health records
Authors: Bernstam Elmer V , Warner Jeremy L , Krauss John C , Ambinder Edward , Rubinstein Wendy S , Komatsoulis George , Miller Robert S , Chen James L 
Published: December 2021

AbstractObjectivesElectronic health records (EHRs) contain a large quantity of machine-readable data. However, institutions choose different EHR vendors, and the same product may be implemented differently at different sites. Our goal was to quantify the interoperability of real-world EHR implementations with respect to clinically relevant structured data.Materials and MethodsWe analyzed de-identified and aggregated data from 68 oncology sites that implemented 1 of 5 EHR vendor products. Using 6 medications and 6 laboratory tests for which well-accepted standards exist, we calculated inter- and intra-EHR vendor interoperability scores.ResultsThe mean intra-EHR vendor interoperability score was 0.68 as compared to a mean of 0.22 for inter-system interoperability, when weighted by number of systems of each type, and 0.57 and 0.20 when not weighting by number of systems of each type.DiscussionIn contrast to data elements required for successful billing, clinically relevant data elements are rarely standardized, even though applicable standards exist. We chose a representative sample of laboratory tests and medications for oncology practices, but our set of data elements should be seen as an example, rather than a definitive list.ConclusionsWe defined and demonstrated a quantitative measure of interoperability between site EHR systems and within/between implemented vendor systems. Two sites that share the same vendor are, on average, more interoperable. However, even for implementation of the same EHR product, interoperability is not guaranteed. Our results can inform institutional EHR selection, analysis, and optimization for interoperability.
How should we appropriately classify low-risk uterine cervical cancer patients suitable for de-intensified treatment?
Authors: Murakami Naoya , Kuno Ikumi , Yoshida Hiroshi , Shiraishi Kouya , Kato Tomoyasu , Igaki Hiroshi 
Published: December 2021

Abstract
We suggested de-escalation would be possible for cervical cancer like human papillomavirus (HPV)-related oropharyngeal cancer. However, the classification was based on tumor shrinkage that can be obtained after half of the treatment was finished. Our other article found adverse factors which can be obtained prior to treatment, and they might classify patients earlier.
Depression and Anxiety as Mediators of PTSD Symptom Clusters and Pain in Treatment-Seeking Canadian Forces Members and Veterans
Authors: Roth Maya , King Lisa , Richardson Don 
Published: December 2021

ABSTRACT

Introduction
Chronic pain (CP) commonly presents alongside psychiatric conditions such as depression, PTSD, and generalized anxiety. The current study sought to better understand this complex relationship by determining whether anxiety and depression symptom severity mediated the relationship between DSM-5 PTSD symptom clusters and pain symptoms in a sample of 663 Canadian Armed Forces (CAF) personnel and veterans seeking treatment for mental health conditions.

Materials and Methods
Generalized anxiety disorder, depression, and PTSD symptom severity were measured using self-report scales provided as part of a standard intake protocol. Pain symptoms were measured using the Bodily Pain subscale of the SF-36 (SF-36 BPS). Linear regressions were used to explore the relationship between PTSD symptom clusters, depression, anxiety, and pain. Bootstrapped resampling analyses were employed to test mediation effects.

Results
The average SF-36 BPS score in this sample was 36.6, nearly 1.5 SDs below the population health status, enforcing the salience of pain symptoms as a concern for veterans and CAF seeking treatment for military-related psychiatric conditions. The effects of PTSD symptom clusters avoidance, negative mood and cognitions, and arousal on pain were fully mediated by anxiety and depression severity. However, the effect of intrusion on pain was not mediated by depression and only partly mediated by anxiety.

Conclusion
Findings emphasize the importance of including anxiety and depression in models of PTSD and pain, particularly in samples where psychiatric comorbidity is high. Clinically, results highlight the need for improved treatment regimens that address pain symptoms alongside common psychiatric comorbidities.
Gradients of chemical abundances in the Milky Way from H ii regions: distances derived from Gaia EDR3 parallaxes and temperature inhomogeneities
Authors: Méndez-Delgado J E , Amayo A , Arellano-Córdova K Z , Esteban C , García-Rojas J , Carigi L , Delgado-Inglada G 
Published: December 2021

ABSTRACT
We present a reassessment of the radial abundance gradients of He, C, N, O, Ne, S, Cl, and Ar in the Milky Way using the deep optical spectra of 42 H ii regions presented in Arellano-Córdova et al. (2020, 2021) and Méndez-Delgado et al. (2020) exploring the impact of: (1) new distance determinations based on Gaia EDR3 parallaxes and (2) the use of Peimbert’s temperature fluctuations paradigm (t2 &gt; 0) for deriving ionic abundances. We find that distances based on Gaia EDR3 data are more consistent with kinematic ones based on Galactic rotation curves calibrated with radio parallaxes, which give less dispersion and uncertainties than those calibrated with spectrophotometric stellar distances. The distances based on the Gaia parallaxes – DR2 or EDR3 – eliminate the internal flattening observed in previous determinations of the Galactic gradients at smaller distances than ∼7 kpc. Abundances and gradients determined assuming t2 &gt; 0 – not only for O but also for the rest of elements – are not affected by the abundance discrepancy problem and give elemental abundances much consistent with the solar ones for most elements. We find that our radial abundance gradient of He is consistent with the most accurate estimates of the primordial He abundance. We do not find evidence of azimuthal variations in the chemical abundances of our sample. Moreover, the small dispersion in the O gradient – indicator of metallicity in photoionized regions – indicate that the gas of the H ii regions is well mixed in the sampled areas of the Galaxy.
Positive Selection and Enhancer Evolution Shaped Lifespan and Body Mass in Great Apes
Authors: Tejada-Martinez Daniela , Avelar Roberto A , Lopes Inês , Zhang Bruce , Novoa Guy , de Magalhães João Pedro , Trizzino Marco 
Published: December 2021

AbstractWithin primates, the great apes are outliers both in terms of body size and lifespan, since they include the largest and longest-lived species in the order. Yet, the molecular bases underlying such features are poorly understood. Here, we leveraged an integrated approach to investigate multiple sources of molecular variation across primates, focusing on over 10,000 genes, including approximately 1,500 previously associated with lifespan, and additional approximately 9,000 for which an association with longevity has never been suggested. We analyzed dN/dS rates, positive selection, gene expression (RNA-seq), and gene regulation (ChIP-seq). By analyzing the correlation between dN/dS, maximum lifespan, and body mass, we identified 276 genes whose rate of evolution positively correlates with maximum lifespan in primates. Further, we identified five genes, important for tumor suppression, adaptive immunity, metastasis, and inflammation, under positive selection exclusively in the great ape lineage. RNA-seq data, generated from the liver of six species representing all the primate lineages, revealed that 8% of approximately 1,500 genes previously associated with longevity are differentially expressed in apes relative to other primates. Importantly, by integrating RNA-seq with ChIP-seq for H3K27ac (which marks active enhancers), we show that the differentially expressed longevity genes are significantly more likely than expected to be located near a novel “ape-specific” enhancer. Moreover, these particular ape-specific enhancers are enriched for young transposable elements, and specifically SINE–Vntr–Alus. In summary, we demonstrate that multiple evolutionary forces have contributed to the evolution of lifespan and body size in primates.
How Academic Health Systems Can Be Ready for the Next Pandemic
Authors: Dzau Victor J. , Ellaissi William F. , Krishnan K. Ranga Rama , Balatbat Celynne A. 
Published: December 2021

The COVID-19 pandemic created significant challenges for academic health systems (AHSs) across their tripartite mission of providing clinical care, conducting research, and educating learners. Despite these challenges, AHSs played an invaluable role in responding to the pandemic. Clinicians worked tirelessly to care for patients, and institutions quickly reoriented their care delivery systems. Furthermore, AHSs played an important role in advancing science, launching studies and clinical trials to examine new vaccines and treatments for COVID-19. However, there is room for improvement; AHSs can use lessons learned from the COVID-19 pandemic to reshape their operations for the future. To prepare for the next pandemic, AHSs must modernize, adapt, and transform their clinical operations, research infrastructure, and educational programs to include public health and to build surveillance capacity for detecting, monitoring, and managing emerging outbreaks.
In this Invited Commentary, the authors describe the opportunities AHSs have to build on their experiences during the COVID-19 pandemic and the ways they can take advantage of their unique strengths in each of their 3 mission areas. Within clinical care, AHSs can reach patients outside traditional clinical settings, build national and regional networks, advance data-driven insights, engage with the community, and support and protect the workforce. Within research, they can leverage data science and artificial intelligence, perform pandemic forecasting, leverage the social and behavioral sciences, conduct clinical trials, and build a research and development preparedness and operational plan. Within education, AHSs can promote remote learning, make interprofessional learning the norm, and build a system of continuing education.
Quality Improvement Initiative in the NICU for Improved Practice of Cuff Blood Pressure Measurements
Authors: Cistone Nicole , Erlenwein Danielle , Bapat Roopali , Ryshen Greg , Thomas Leslie , Haghnazari Maria S. , Thomas Roberta , Foor Nicholas , Fathi Omid 
Published: December 2021

Background:
Extreme preterm infants face lengthy hospitalizations and are often subjected to painful stimuli. These stimuli may be related to routine caregiving that may negatively impact long-term developmental outcomes. Frequently obtained cuff blood pressure (BP) measurements are an example of a potentially noxious stimulus to preterm infants that may have a cumulating impact on development.

Purpose:
The primary aim was to explore the frequency of cuff BP measurements obtained in hemodynamically stable extreme preterm infants in the neonatal intensive care unit (NICU). Our secondary aim was to reduce the number of cuff BP measurements obtained in hemodynamically stable extreme preterm infants in the NICU.

Methods:
Quality improvement methodologies per the Institute for Healthcare Improvement were used combined with a multidisciplinary approach. Participants were infants born less than 27 weeks of gestation and discharged home. The baseline period was 2015 through Q2-2018 and the intervention period was Q3-2018 through Q1-2020. The electronic medical record was used to collect data and Minitab Statistical Software was used for data analysis.

Findings/Results:
A baseline of 5.0% of eligible patients received the desired number of cuff BP measurements and increased to 63.2% after the intervention period.

Implications for Practice:
Findings demonstrate that using quality improvement methodology can improve clinical care. Findings suggest the feasibility and safety of reducing the number of cuff BP measurements obtained on hemodynamically stable infants in the NICU.

Implications for Research:
Future endeavors should aim to reduce the quantity of painful stimuli in the NICU. Long-term developmental outcomes should be correlated in these patients.
Neonatal Care Provider Tasks for Hospitalized Well Newborns
Authors: Smith Misty , Bosque Elena 
Published: December 2021

Background:
Changes in the pediatrician's practice model have created demand for other medical care providers for hospitalized well newborns. Well newborn care may be the responsibility of those who work in any level I-IV neonatal intensive care units, whether in a primary or secondary role. No recent publications exist about how to approach the organization of tasks.

Purpose:
The purpose of this article is to present a structure and resources to guide the organization of tasks in the care of hospitalized well newborns for learners or occasional care providers.

Methods:
The methods used in this project included literature review to develop evidence-based practice resources. The literature was reviewed regarding the relevant history and resources to support task organization of well newborn care provided by skilled providers in the hospital. The goal is to establish a reference to support education about these approaches, which appear to be rooted in tradition.

Findings:
Evidence-based resources include an overview of provider tasks and responsibilities for well newborn care for each hospital day and per shift.

Implication for Research:
Future studies can measure mentor or learner perceptions of the value of these resources, critical thinking improvement, safety, and clinical outcomes.

Implication for Practice:
These resources may provide structure for learners or occasional providers who have studied the physiology, pathophysiology, and problem management concepts but need to learn how to execute their responsibilities in these busy environments.
Elongation-Derotation-Flexion Casting Treatment of Early-Onset Progressive Scoliosis in Skeletal Dysplasia
Authors: Ulusaloglu Armagan C. , Asma Ali , Rogers Kenneth J. , Bowen James Richard , Mackenzie William G. , Mackenzie William Giles Stuart 
Published: December 2021

Background:
Early-onset scoliosis in children with skeletal dysplasia is progressive, contributing to cardiopulmonary restrictive disease. Serial elongation-derotation-flexion (EDF) casting, used in other etiologies of scoliosis to delay curve progression, may be beneficial in maximizing spine growth. Our hypothesis is serial EDF casting can be safely used as a temporary alternative to surgery, delaying progression and preserving growth, to treat scoliosis in skeletal dysplasia.

Methods:
All patients with skeletal dysplasia treated at a single institution with serial EDF casting for scoliosis were reviewed retrospectively. Radiographic parameters: Cobb angle of major and minor curves, curve location, thoracic height, thoracolumbar height, space available for lung, and rib vertebra angle difference were measured before casting (C1), in first casting (C2), in last casting (C3), and out of last casting (C4). Peak inspiratory pressure (PIP) values were monitored and recorded during the casting application.

Results:
Eleven patients met the inclusion criteria (mean 9.7 castings). The mean duration of EDF serial casting was 35 months. The mean major Cobb angles were 54 degrees° (C1), 30 degrees (C2), 37 degrees (C3), and 49 degrees (C4) with no statistically significant differences. The mean minor Cobb angles were 35 degrees (C1), 25 degrees (C2), 33 degrees (C3), and 51 degrees (C4) with no statistically significant differences. The mean thoracic heights were 130 mm (C1), 155 mm (C2), 173 mm (C3), and 160 mm (C4). The 19-mm mean difference between C2 and C3 represents spinal growth. The PIP-1, PIP-2, and PIP-3 mean values were 15, 27, and 18 cmH2O, respectively. Changes in PIP-1 and PIP-2 and PIP-2 and PIP-3 were statistically significant.

Conclusion:
Serial EDF casting can delay surgical scoliosis correction in children younger than 7 years with a diagnosis of skeletal dysplasia. Our study showed that serial casting controls progression of the major curve and allows longitudinal growth of the spine with possible expansion of lung volume for nearly 3 years. During cast application, PIP increased with molding and traction, and improved until windowing and trimming of the cast.

Level of Evidence:
Level IV—retrospective study.