bluuebunny/crossref_metadata_2025_split huggingface dataset:
The procedural syntax of fake modification constructions in Chinese
Authors: Li Wenshan 
Published: February 2021

AbstractThe clitic morphemedein Mandarin Chinese has various uses. Typically, it is cliticized to a phrase whether the phrase is nominal or adjectival; it can also occur between two noun phrases when there is no relation of semantic modification. The constructions that involve the latter use ofde, known as fake modification constructions, have been theoretically characterized many a time. In the existing characterizations, the morpheme is treated either as a mysteriously inserted lexical item, a modification marker, or a genitive morpheme. The existing accounts suffer from a variety of theoretical and empirical problems. Evidence is presented that in some other constructions and in fake modification constructions,de, while having no lexical semantic content of its own, occupies a position that is otherwise occupied by a two-place predicate. Based on this observation, a partially unitary theoretical account of fake modification constructions is formulated from a parsing perspective in the framework of Dynamic Syntax. In this account, fourde-morphemes in fake modification constructions are recognized with different syntactic distributions; however, they all contribute a semantically underspecified predicate that is updated by syntactically constrained or context-based inference.
Norwegian Emergency Medicine Systems’ Training and Equipment for Penetrating Injuries: A National Survey-Based Study
Authors: Blix Sigurd W. , Melau Jørgen , Thorvaldsen Nina , Lund-Kordahl Inger 
Published: February 2021

AbstractObjective:Recent terror attacks led the Norwegian government to develop a procedure for emergency and law enforcement services cooperation during Active Violent Incidents (AVI, abbreviated PLIVO in Norwegian). To address further national initiatives to improve preparedness for mass casualty events and penetrating injuries among emergency medical services (EMS) in Norway, training and equipment status were mapped.Methods:All EMS regions in Norway were invited to participate in an electronic nation-wide survey about practical medical training in PLIVO scenario training and specific training in hemorrhage control and penetrating injuries.Results:Ninety percent (842/938) had attended at least 1 PLIVO training scenario. Of these, 76% (642/938) reported only evacuation training during the exercise, while only 20% (168/938) had practiced hemorrhage control. Eighty-one percent (760/938) respondents reported that they were equipped with tourniquets and 91% (853/938) were equipped with gauze to pack wounds. However, only 52% (487/938) and 48% (450/938) reported practical training in tourniquet application and wound packing, respectively, while 30% (280/938) reported that they had no training or only theoretical education in tourniquet application. Supervised practical training on penetrating thoracic injuries was reported by <20%, and <50% reported practical training in needle decompression of a tension pneumothorax.Conclusions:Enhanced focus on training in hemorrhage control and penetrating injuries is needed. This supports the recent decision from the Norwegian government to strengthen the training for EMS in AVI (PLIVO) exercises, by focusing on medical procedures in addition to evacuation training. Although the estimated response rate is 17%, we believe the large number of respondents still make the results valuable.
Interaction between Apo A-II -265T>C polymorphism and dietary total antioxidant capacity on some anthropometric indices and serum lipid profile in patients with type 2 diabetes mellitus
Authors: Jafari Azad Banafsheh , Yaseri Mehdi , Daneshzad Elnaz , Koohdani Fariba 
Published: February 2021

Abstract
The present study aimed to investigate the interaction of Apo A-II polymorphism and dietary total antioxidant capacity (DTAC) with lipid profile and anthropometric markers in patients with type 2 diabetes (T2DM) that are at risk for atherosclerosis. This cross-sectional study was conducted on 778 patients with T2DM (35–65 years). Dietary intakes were assessed by a 147-item food frequency questionnaire. DTAC was computed using international databases. Participants were categorised into two groups based on rs5082 genotypes. The gene–diet interaction was analysed by an ANCOVA multivariate interaction model. Total cholesterol, TC; triacylglycerol, TG; high- and low-density lipoprotein, HDL and LDL; TC–HDL ratio; waist circumference, WC and body mass index, BMI were obtained according to standard protocols. Overall, the frequency of CC homozygous was 12⋅1 % among study participants. We found that a significant interaction between rs5082 variants and DTAC on mean WC (PTEAC = 0⋅044), TC concentration (PFRAP = 0⋅049 and PTEAC = 0⋅031) and TC/HDL (PFRAP = 0⋅031 and PTRAP = 0⋅040). Among patients whose DTAC was higher than the median intake, the mean of weight, WC and TC/HDL were significantly higher only in individuals with CC genotype. Also, the high DTAC was associated with a lower TC concentration only in T-allele carriers (PFRAP = 0⋅042). We found that adherence to a diet with high total antioxidant capacity can improve the complications of diabetes and atherosclerosis in the T carrier genotype more effectively than the CC genotype. These results could indicate the anti-atherogenic properties of Apo A-II. However, further studies are needed to shed light on this issue.
The Emergence of New Paramilitary Organizations in Bulgaria and Yugoslavia after the First World War
Authors: Tasić Dmitar 
Published: February 2021

AbstractAs elsewhere in Europe after the First World War, the Balkans went through a process of “paramilitarization.” Unlike the rest of Europe, there existed a strong indigenous paramilitary culture originating from the time of Ottoman rule. In the interconnected, harsh political realities of victorious Yugoslavia and vanquished Bulgaria, both states and their political elites resolved to create new paramilitary formations. While in the case of Yugoslavia and its Organization Against Bulgarian Bandits there was a resurgence of an older style paramilitary formation, in Bulgaria leading figures of the ruling Bulgarian Agrarian National Union decided to create the Orange Guards—a completely new paramilitary formation based on the existing structure of their party. The common denominator for both formations was the threat posed by the Internal Macedonian Revolutionary Organization for security, territorial integrity, and the normal development of both states. As in most cases of paramilitary formation, their existence and actions were followed by violence, often marked by extreme brutality. Both the agrarian regime and Orange Guards perished in the violent summer of 1923, when a carefully planned and executed coup d’état ended the agrarian revolutionary attempt to transform Bulgarian society. The Organization Against Bulgarian Bandits, under the new name of Peoples Self-Defense, continued to function throughout the existence of the Yugoslav kingdom.
Remnant radio galaxies discovered in a multi-frequency survey
Authors: Quici Benjamin , Hurley-Walker Natasha , Seymour Nicholas , Turner Ross J. , Shabala Stanislav S. , Huynh Minh , Andernach H. , Kapińska Anna D. , Collier Jordan D. , Johnston-Hollitt Melanie , White Sarah V. , Prandoni Isabella , Galvin Timothy J. , Franzen Thomas , Ishwara-Chandra C. H. , Bellstedt Sabine , Tingay Steven J. , Gaensler Bryan M. , O’Brien Andrew , Rogers Johnathan , Chow Kate , Driver Simon , Robotham Aaron 
Published: February 2021

AbstractThe remnant phase of a radio galaxy begins when the jets launched from an active galactic nucleus are switched off. To study the fraction of radio galaxies in a remnant phase, we take advantage of a$8.31$deg$^2$subregion of the GAMA 23 field which comprises of surveys covering the frequency range 0.1–9 GHz. We present a sample of 104 radio galaxies compiled from observations conducted by the Murchison Widefield Array (216 MHz), the Australia Square Kilometer Array Pathfinder (887 MHz), and the Australia Telescope Compact Array (5.5 GHz). We adopt an ‘absent radio core’ criterion to identify 10 radio galaxies showing no evidence for an active nucleus. We classify these as new candidate remnant radio galaxies. Seven of these objects still display compact emitting regions within the lobes at 5.5 GHz; at this frequency the emission is short-lived, implying a recent jet switch off. On the other hand, only three show evidence of aged lobe plasma by the presence of an ultra-steep-spectrum ($\alpha<-1.2$) and a diffuse, low surface brightness radio morphology. The predominant fraction of young remnants is consistent with a rapid fading during the remnant phase. Within our sample of radio galaxies, our observations constrain the remnant fraction to$4\%\lesssim f_{\mathrm{rem}} \lesssim 10\%$; the lower limit comes from the limiting case in which all remnant candidates with hotspots are simply active radio galaxies with faint, undetected radio cores. Finally, we model the synchrotron spectrum arising from a hotspot to show they can persist for 5–10 Myr at 5.5 GHz after the jets switch of—radio emission arising from such hotspots can therefore be expected in an appreciable fraction of genuine remnants.
Domestic Politics, China's Rise, and the Future of the Liberal International Order
Authors: Weiss Jessica Chen , Wallace Jeremy L. 
Published: February 2021

AbstractWith the future of liberal internationalism in question, how will China's growing power and influence reshape world politics? We argue that views of the Liberal International Order (LIO) as integrative and resilient have been too optimistic for two reasons. First, China's ability to profit from within the system has shaken the domestic consensus in the United States on preserving the existing LIO. Second, features of Chinese Communist Party rule chafe against many of the fundamental principles of the LIO, but could coexist with a return to Westphalian principles and markets that are embedded in domestic systems of control. How, then, do authoritarian states like China pick and choose how to engage with key institutions and norms within the LIO? We propose a framework that highlights two domestic variables—centrality and heterogeneity—and their implications for China's international behavior. We illustrate the framework with examples from China's approach to climate change, trade and exchange rates, Internet governance, territorial sovereignty, arms control, and humanitarian intervention. Finally, we conclude by considering what alternative versions of international order might emerge as China's influence grows.
Depression and anxiety in healthcare professionals during the COVID-19 pandemic
Authors: Weibelzahl S. , Reiter J. , Duden G. 
Published: February 2021

Abstract
Healthcare staff have been at the centre of the fight against the COVID-19 pandemic, facing diverse work-related stressors. Building upon studies from various countries, we aimed to investigate (1) the prevalence of various work-related stressors among healthcare professionals in Germany specific to the COVID-19 pandemic, (2) the psychological effects of these stressors in terms of clinical symptoms, and (3) the healthcare professionals' help-seeking behaviour. To this end, N = 300 healthcare professionals completed an online survey including the ICD-10 Symptom Rating checklist (ISR), event-sampling questions on pandemic-related stressors and self-formulated questions on help-seeking behaviour. Participants were recruited between 22 May and 22 July 2020. Findings were analysed using t tests, regressions and comparisons to large clinical and non-clinical samples assessed before and during the pandemic. Results show that healthcare professionals were most affected by protective measures at their workplace and changes in work procedures. Psychological symptoms, particularly anxiety and depression, were significantly more severe than in a non-clinical pre-pandemic sample and in the general population during the pandemic. At the same time, most professionals indicated that they would not seek help for psychological concerns. These findings indicate that healthcare employers need to pay greater attention to the mental health of their staff.
Carbon-reducing innovation as the essential policy frontier – towards finding the ways that work
Authors: Convery Frank J. 
Published: February 2021

AbstractFinding the ways that work to deliver the innovation needed should be given parity of esteem with getting the prices right as a focus of the economics profession and policy systems. Learn from experience as regards carbon pricing and carbon-reducing innovation; insights from the latter coming mainly from the US, China and Europe; demographically relatively small countries – Denmark (wind) and Australia (solar PV) – can make outsize contributions. A carbon price ceiling is too low to drive innovation; generating carbon-reducing innovation requires that it be explicitly recognized as a priority, and nurtured accordingly: identify the priority area(s) where innovation at scale will be necessary to make progress; baseline the elements of the innovation ecosystem which are already in place, and the gaps that need to be filled. Key elements include institutions and incentives that promote innovation, a research and enterprise community that make it happen, and a supportive public.
Colorectal cancer incidence in Australia before and after mandatory fortification of bread flour with folic acid
Authors: van der Pols Jolieke C , Baade Peter , Spencer Lauren B 
Published: February 2021

Abstract

Objective:
Mandatory fortification of bread flour with folic acid has helped to reduce the incidence of neural tube defects in several countries. However, it has been suggested that folic acid may have potential adenoma-promoting effects, and reports from some countries have suggested that mandatory folic acid food fortification programmes have increased the incidence of colorectal cancer. The objective of this study was to evaluate colorectal cancer incidence patterns before and after introduction of mandatory folic acid fortification of bread flour in Australia in 2009.

Design:
Data from the Australian Cancer Database were used to plot age-standardised incidence of colorectal cancer. We calculated age-adjusted rate ratios with 95 % CIs.

Setting:
Australia.

Participants:
We used population-level aggregate data obtained from cancer registries.

Results:
Age-standardised colorectal cancer incidence generally decreased between 1999 and 2016. Although there was a slight increase in rates in 2010 compared with 2009 (62·8 v. 61·6 cases per 100 000, age-adjusted rate ratio 1·02 (95 % CI 0·99, 1·04), joinpoint regression indicated decreases of –0·4 % (95 % CI –0·7, 0·0) per year from 1999 to 2010 and –2·2 % (95 % CI –3·1, –1·3) per year from 2010 to 2016.

Conclusions:
While causation cannot be assessed from these population-level data, our observations indicate that there is no evidence that introduction of mandatory folic acid fortification of bread flour has influenced colorectal cancer incidence in Australia.
Hot Jupiters: Origins, Structure, Atmospheres
Authors: Fortney Jonathan J. , Dawson Rebekah I. , Komacek Thaddeus D. 
Published: February 2021

AbstractWe provide a brief review of many aspects of the planetary physics of hot Jupiters. Our aim is to cover most of the major areas of current study while providing the reader with additional references for more detailed follow‐up. We first discuss giant planet formation and subsequent orbital evolution via disk‐driven torques or dynamical interactions. More than one formation pathway is needed to understand the population. Next, we examine our current understanding of the evolutionary history and current interior structure of the planets, where we focus on bulk composition as well as viable models to explain the inflated radii of the population. Finally, we discuss aspects of their atmospheres in the context of observations and 1D and 3D models, including atmospheric structure and escape, spectroscopic signatures, and complex atmospheric circulation. The major opacity sources in these atmospheres, including alkali metals, water vapor, and others, are discussed. We discuss physics that control the 3D atmospheric circulation and day‐to‐night temperature structures. We conclude by suggesting important future work for still‐open questions.
Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ
Authors: Ye Zuodong , Wang Dawei , Lu Yingying , He Yunjiao , Yu Jingting , Wei Wenjie , Chen Chang , Wang Rui , Zhang Liang , Zhang Liangren , Le Minh T. N. , Cho William C. , Yang Mengsu , Zhang Hongmin , Yue Jianbo 
Published: February 2021

AbstractMetastasis is the fundamental cause of cancer mortality, but there are still very few anti-metastatic drugs available. Endosomal trafficking has been implicated in tumor metastasis, and we have previously found that small chemical vacuolin-1 (V1) potently inhibits autophagosome-lysosome fusion and general endosomal-lysosomal degradation. Here, we assessed the anti-metastatic activity of V1 both in vitro and in vivo. V1 significantly inhibits colony formation, migration, and invasion of various cancer cells in vitro. It also compromises the assembly-disassembly dynamics of focal adhesions (FAs) by inhibiting the recycling and degradation of integrins. In various experimental or transgenic mouse models, V1 significantly suppresses the metastasis and/or tumor growth of breast cancer or melanoma. We further identified capping protein Zβ (CapZβ) as a V1 binding protein and showed that it is required for the V1-mediated inhibition of migration and metastasis of cancer cells. Collectively, our results indicate that V1 targets CapZβ to inhibit endosomal trafficking and metastasis.
Long-term biopsy outcomes in prostate cancer patients treated with external beam radiotherapy: a systematic review and meta-analysis
Authors: Singh Saurabh , Moore Caroline M. , Punwani Shonit , Mitra Anita V. , Bandula Steve 
Published: February 2021

Abstract
Background
Biopsy after external beam radiotherapy (EBRT) for localised prostate cancer (PCa) is an infrequently used but potentially valuable technique to evaluate local recurrence and predict long-term outcomes.

Methods
We performed a meta-analysis of studies until March 2020 where a post-EBRT biopsy was performed on patients with low-to intermediate risk PCa, according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. The primary outcome was the aggregate post-EBRT positive biopsy rate (≥2 years after EBRT) and the associated odds ratio (OR) of a positive biopsy on biochemical failure (BCF), distant metastasis-free survival (DMFS) and prostate cancer-specific mortality (PCSM). A sensitivity analysis was performed which examined biopsy rate as a function of post-EBRT biopsy protocol, PCa risk, ADT usage and radiation dose.

Results
A total of 22 studies were included, of which 10 were randomised controlled trials and 12 were cohort studies. Nine out of the 22 studies used dosing regimens consistent with the 2020 NCCN radiotherapy guidelines. The weighted-average positive biopsy rate across all 22 studies was 32% (95%-CI: 25–39%, n = 3017). In studies where post-treatment biopsy was part of the study protocol, the rate was 35% (95%-CI: 21–38%, n = 2450). In the subgroup of studies that conformed to the 2020 NCCN radiotherapy guidelines, this rate was 22% (95% CI: 19–41%, n = 832). Patients with positive biopsy had a 10-fold higher odds of developing BCF (OR of 10.3, 95%-CI: 3.7–28.7, p < 0.00001), 3-fold higher odds of developing distant metastasis (OR 3.1, 95%-CI: 2.1–4.7, p < 0.00001) and 5-fold higher odds of dying from their PCa (OR 5.1, 95%-CI: 2.6–10, p < 0.00001).

Conclusion
A positive biopsy after EBRT is associated with a poor prognosis compared to a negative biopsy. The post-EBRT positive biopsy rate is an important measure which provides additional insight when comparing EBRT to other treatment modalities for PCa.
Psychological distress in men with prostate cancer undertaking androgen deprivation therapy: modifying effects of exercise from a year-long randomized controlled trial
Authors: Galvão Daniel A. , Newton Robert U. , Chambers Suzanne K. , Spry Nigel , Joseph David , Gardiner Robert A. , Fairman Ciaran M. , Taaffe Dennis R. 
Published: February 2021

Abstract
Objectives
To assess the long-term effects of various exercise modes on psychological distress in men with prostate cancer on androgen deprivation therapy (ADT).

Patients and methods
135 prostate cancer patients aged 43–90 years on ADT were randomized to twice weekly supervised impact loading and resistance exercise (ImpRes), supervised aerobic and resistance exercise (AerRes), and usual care/delayed supervised aerobic exercise (DelAer) for 12 months, and completed measures of psychological distress using the Brief Symptom Inventory-18 (BSI-18). BSI-18 provides three subscales for anxiety, depression, and somatisation, as well as the global severity index (GSI) where higher scores indicate higher distress.

Results
Following the intervention, somatization was not different to baseline, however, there were significant interactions (p < 0.01) for depression, anxiety, and the GSI. In ImpRes, depression was reduced at 12 months compared to baseline and 6 months (0.78 ± 1.39 vs. 1.88 ± 3.24 and 1.48 ± 2.65, p < 0.001), as was the GSI (3.67 ± 4.34 vs. 5.94 ± 7.46 and 4.64 ± 4.73, p < 0.001) with anxiety reduced compared to baseline (1.08 ± 1.54 vs. 1.98 ± 2.56). Depression and the GSI decreased (p < 0.05) in AerRes at 6 months but increased by 12 months, while in DelAer the GSI was reduced at 12 months compared to 6 months (3.78 ± 3.94 vs. 5.25 ± 4.22, p = 0.031). Men with the highest level of anxiety, depression, somatization, and the GSI improved the most with exercise (ptrend < 0.001).

Conclusion
Various supervised exercise modes (aerobic, resistance and impact loading) are effective in reducing psychological distress in men with prostate cancer on ADT. Those with the highest level of psychological distress improved the most. Supervised exercise should be prescribed to improve psychological health in prostate cancer patients on ADT.