bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reserves for reducing the frequency of cesarean section in a level 3A hospital
Authors: Lebedenko E. Yu. , Bespalaya A. V. , Mikhelson A. A. , Feoktistova T. E. , Kormanukov H. Yu. 
Published: December 2024

Objective: to substantiate the reserves for reducing the frequency of cesarean section in a level 3 A hospital by retrospectively analyzing delivered patients using the M. Robson classiﬁcation.Materials and methods: a retrospective analysis of 3771 birth histories of patients delivered in 2017 at the Rostov State “Perinatal center” was carried out. The patients were divided into 10 groups according to M. Robson's classiﬁcation. The results were processed using mathematical statistics methods using MS Excel 2010 soﬅware.Results: an analysis of delivery methods showed that out of 3,771 deliveries, 2018 women were delivered by abdominal delivery, which accounted for 53.2% of the total number of births in 2017. A detailed analysis of the indications for cesarean section in each of the groups according to M. Robson's classiﬁcation revealed the true reserve for reducing the overall level of abdominal delivery in the studied institution.Conclusions: in order to structure in detail the reserves for reducing the frequency of cesarean section in a particular institution and to compare this indicator between maternity care institutions, in addition to the traditional analysis according to M. Robson's classiﬁcation, it is necessary to develop and implement a uniﬁed form of analysis taking into account indications for abdominal delivery.
Immunotherapy in patients with recurrent implantation failure
Authors: Trunova O. A. , Gulmamedova I. D. , Maylyan E. A. 
Published: December 2024

Objective: to evaluate the eﬀect of personalized immunotherapy on the frequency of pregnancy and gestation in women with recurrent implantation failure.Materials and methods: the clinical immunogram before and aﬅer courses of personalized immunotherapy in 65 women with a history of recurrent implantation failure during the period of preparation for treatment under the ART program (24 cryoprotocols in the natural cycle, 41 cryoprotocols with hormone replacement therapy without pituitary blockade): CD3+, CD3+CD4+, CD3+CD8+, CD3+CD20+, CD16+ in direct reaction of surface immunoﬂuorescence using monoclonal antibodies; concentration of serum Ig G, A, M by ELISA; total circulating immune complexes; Nitroblue tetrazolium (NBT) dye reduction test; phagocytic activity of neutrophils.Results: the immune status of 100% of patients with secondary infertility and 36.4% of women with primary infertility is characterized by secondary T-immunodeﬁciency and signiﬁcant activation of both B-lymphocytes and cellular factors of nonspeciﬁc body protection — peripheral NK cells (CD16+) and neutrophils. Repeated courses of personalized immunotherapy in women with a history of recurrent implantation failure led to normalization of altered immune parameters and showed their eﬀectiveness in 67.7% of patients who gave birth to live children.Conclusion: one of the leading reasons for habitual ineﬀective implantation in the presence of euploid embryos of good quality is general and local (endometrial) immunological imbalance. A personalized approach to the selection of immunotherapy for each patient optimizes the frequency of implantation, the onset and outcome of pregnancy.
The innate immune response is a key player in the process of coronary artery and aortic valve calcification
Authors: Shlyk I. F. , Kharitonova M. V. , Morgunov M. N. , Blinov I. M. , Vasilyeva E. D. , Besedina D. Yu. 
Published: December 2024

The presented literature review allows us to understand and supplement the existing ideas about the pathogenesis of coronary calciﬁcation and aortic valve calciﬁcation at the stage of formation of these changes. To study in detail the participation of the most studied immunocompetent cells of innate immunity, such as macrophages, dendritic and mast cells, neutrophils, natural killers in calciﬁcation of arteries and aortic valve, their functional role in the progression of this process. The review also presents gaps and missing data present in the study of these cell populations, the replenishment of which will contribute to the development of targeted therapy for the calciﬁcation process.The search for literature sources was conducted in the following databases: Scopus, web of Science, MedLine, The Cochrane Library, RSCI, Springer, Science Direct — taking into account the year of publication (no more than 10 years), language of publication (English/Russian), availability of full-text publications and access to them.
Changes in Physical Activity Across Cancer Diagnosis and Treatment Based on Smartphone Step Count Data Linked to a Japanese Claims Database: Retrospective Cohort Study
Authors: Inayama Yoshihide , Yamaguchi Ken , Mizuno Kayoko , Tanaka-Mizuno Sachiko , Koike Ayami , Higashiyama Nozomi , Taki Mana , Yamanoi Koji , Murakami Ryusuke , Hamanishi Junzo , Yoshida Satomi , Mandai Masaki , Kawakami Koji 
Published: December 2024

Background
Although physical activity (PA) is recommended for patients with cancer, changes in PA across cancer diagnosis and treatment have not been objectively evaluated.

Objective
This study aimed to assess the impact of cancer diagnosis and treatment on PA levels.

Methods
This was a retrospective cohort study using a Japanese claims database provided by DeSC Healthcare Inc, in which daily step count data, derived from smartphone pedometers, are linked to the claims data. In this study, we included patients newly diagnosed with cancer, along with those newly diagnosed with diabetes mellitus for reference. We collected data between April 2014 and September 2021 and analyzed them. The observation period spanned from 6 months before diagnosis to 12 months after diagnosis. We applied a generalized additive mixed model with a cubic spline to describe changes in step counts before and after diagnosis.

Results
We analyzed the step count data of 326 patients with malignant solid tumors and 1388 patients with diabetes. Patients with cancer exhibited a 9.6% (95% CI 7.1%-12.1%; P<.001) reduction in step counts from baseline at the start of the diagnosis month, which further deepened to 12.4% (95% CI 9.5%-15.2%; P<.001) at 3 months and persisted at 7.1% (95% CI 4.2%-10.0%; P<.001) at 12 months, all relative to baseline. Conversely, in patients with diabetes, step counts remained relatively stable after diagnosis, with a slight upward trend, resulting in a change of +0.6% (95% CI –0.6% to 1.9%; P=.31) from baseline at 3 months after diagnosis. At 12 months after diagnosis, step counts remained decreased in the nonendoscopic subdiaphragmatic surgery group, with an 18.0% (95% CI 9.1%-26.2%; P<.001) reduction, whereas step counts returned to baseline in the laparoscopic surgery group (+0.3%, 95% CI –6.3% to 7.5%; P=.93).

Conclusions
The analysis of objective pre- and postdiagnostic step count data provided fundamental information crucial for understanding changes in PA among patients with cancer. While cancer diagnosis and treatment reduced PA, the decline may have already started before diagnosis. The study findings may help tailor exercise recommendations based on lifelog data for patients with cancer in the future.
Evaluation of a Telemonitoring System Using Electronic National Early Warning Scores for Patients Receiving Medical Home Care: Pilot Implementation Study
Authors: Lin Cheng-Fu , Chang Pei‐Jung , Chang Hui-Min , Chen Ching-Tsung , Hsu Pi-Shan , Wu Chieh-Liang , Lin Shih-Yi 
Published: December 2024

Abstract

Background
Telehealth programs and wearable sensors that enable patients to monitor their vital signs have expanded due to the COVID-19 pandemic. The electronic National Early Warning Score (e-NEWS) system helps identify and respond to acute illness.

Objective
This study aimed to implement and evaluate a comprehensive telehealth system to monitor vital signs using e-NEWS for patients receiving integrated home-based medical care (iHBMC). The goal was to improve the early detection of patient deterioration and enhance care delivery in home settings. The system was deployed to optimize remote monitoring in iHBMC and reduce emergency visits and hospitalizations.

Methods
The study was conducted at a medical center and its affiliated home health agency in central Taiwan from November 1, 2022, to October 31, 2023. Patients eligible for iHBMC were enrolled, and sensor data from devices such as blood pressure monitors, thermometers, and pulse oximeters were transmitted to a cloud-based server for e-NEWS calculations at least twice per day over a 2-week period. Patients with e-NEWSs up to 4 received nursing or physician recommendations and interventions based on abnormal physiological data, with reassessment occurring after 2 hours.

Implementation (Results)
A total of 28 participants were enrolled, with a median age of 84.5 (IQR 79.3‐90.8) years, and 32% (n=9) were male. All participants had caregivers, with only 5 out of 28 (18%) able to make decisions independently. The system was implemented across one medical center and its affiliated home health agency. Of the 28 participants, 27 completed the study, while 1 exited early due to low blood pressure and shortness of breath. The median e-NEWS value was 4 (IQR 3‐6), with 397 abnormal readings recorded. Of the remaining 27 participants, 8 participants had earlier home visits due to abnormal readings, 6 required hypertension medication adjustments, and 9 received advice on oxygen supplementation. Overall, 24 out of 28 (86%) participants reported being satisfied with the system.

Conclusions
This study demonstrated the feasibility of implementing a telehealth system integrated with e-NEWS in iHBMC settings, potentially aiding in the early detection of clinical deterioration. Although caregivers receive training and resources for their tasks, the system may increase their workload, which could lead to higher stress levels. The small sample size, short monitoring duration, and regional focus in central Taiwan may further limit the applicability of the findings to areas with differing countries, regions, and health care infrastructures. Further research is required to confirm its impact.
ChatGPT-4 Performance on German Continuing Medical Education—Friend or Foe (Trick or Treat)? Protocol for a Randomized Controlled Trial
Authors: Burisch Christian , Bellary Abhav , Breuckmann Frank , Ehlers Jan , Thal Serge C , Sellmann Timur , Gödde Daniel 
Published: December 2024

Background
The increasing development and spread of artificial and assistive intelligence is opening up new areas of application not only in applied medicine but also in related fields such as continuing medical education (CME), which is part of the mandatory training program for medical doctors in Germany. This study aimed to determine whether medical laypersons can successfully conduct training courses specifically for physicians with the help of a large language model (LLM) such as ChatGPT-4. This study aims to qualitatively and quantitatively investigate the impact of using artificial intelligence (AI; specifically ChatGPT) on the acquisition of credit points in German postgraduate medical education.

Objective
Using this approach, we wanted to test further possible applications of AI in the postgraduate medical education setting and obtain results for practical use. Depending on the results, the potential influence of LLMs such as ChatGPT-4 on CME will be discussed, for example, as part of a SWOT (strengths, weaknesses, opportunities, threats) analysis.

Methods
We designed a randomized controlled trial, in which adult high school students attempt to solve CME tests across six medical specialties in three study arms in total with 18 CME training courses per study arm under different interventional conditions with varying amounts of permitted use of ChatGPT-4. Sample size calculation was performed including guess probability (20% correct answers, SD=40%; confidence level of 1–α=.95/α=.05; test power of 1–β=.95; P<.05). The study was registered at open scientific framework.

Results
As of October 2024, the acquisition of data and students to participate in the trial is ongoing. Upon analysis of our acquired data, we predict our findings to be ready for publication as soon as early 2025.

Conclusions
We aim to prove that the advances in AI, especially LLMs such as ChatGPT-4 have considerable effects on medical laypersons’ ability to successfully pass CME tests. The implications that this holds on how the concept of continuous medical education requires reevaluation are yet to be contemplated.

Trial Registration
OSF Registries 10.17605/OSF.IO/MZNUF; https://osf.io/mznuf

International Registered Report Identifier (IRRID)
PRR1-10.2196/63887
The Impacts of Audiovisual Content in Digital Marketing: a Study on Companies Using the Method in São Luís – Maranhão
Authors: Façanha Neto Inácio Ferreira , Rodrigues Yasmin Sousa 
Published: December 2024

Objective: The objective of this study is to investigate the impacts of using audiovisual content in the digital marketing strategies of companies in São Luís, Maranhão, aiming to understand how this tool contributes to audience engagement, brand strengthening, and increased sales.

Theoretical Framework: This section presents the key concepts and theories that underpin the research. It highlights analyses of audiovisual content as a communication tool (Vidigal, 2023; Coutinho, 2006), digital marketing and its strategies (Kotler and Keller, 2010; Ferreira, 2015), and the influence of consumer psychology on visual communication (Corredor, 2013; Justo and Massimi, 2017). These concepts provide a solid foundation for understanding the impact of audiovisual content in digital marketing.

Method: The methodology adopted for this research involves a qualitative and quantitative approach, combining theoretical analysis with empirical data. Data collection was conducted through a structured questionnaire applied to companies in São Luís, covering micro, small, medium, and large organizations. Aspects such as the type of audiovisual content used, impact on engagement metrics, sales, and brand strengthening were explored.

Results and Discussion: The results revealed that the use of promotional and institutional videos significantly contributes to audience engagement and brand strengthening. Companies reported a high return on investment (ROI), with Instagram highlighted as the most effective platform. In the discussion, the results are contextualized in light of the theoretical framework, highlighting challenges such as high production costs and alignment with the brand's visual identity.

Research Implications: The practical implications of this research include guidelines for optimizing the use of audiovisual content in digital marketing. In the marketing field, the results can influence practices such as adopting personalized content and investing in paid ads to enhance reach and engagement.

Originality/Value: This study contributes to the literature by exploring the impact of audiovisual content in the regional context of São Luís, Maranhão, highlighting its effectiveness as a strategic marketing tool. The research is relevant as it underscores the importance of content personalization and evaluation metrics in the digital environment.
RAPID GENOTYPING OF PRNP GENE POLYMORPHISMS TO ASSESS SCRAPIE SUSCEPTIBILITY IN BRAZILIAN SHEEP
Authors: Rodrigues Camila Souza , Faria Danielle Assis de , Silva Kleibe de Moraes , Facó Olivardo , Azevedo Hymerson Costa , Moraes José Carlos Ferrugem , Souza Carlos José Hoff de , Caetano Alexandre Rodrigues , McManus Concepta , Paiva Samuel Rezende 
Published: December 2024

Objective: Our study aimed to develop and validate a low-density SNP panel for 15 PRNP gene polymorphisms for genotyping sheep from 15 breeds in Brazil, incorporating samples from the Brazilian Animal Germplasm Biobank (BBGA). It was estimated both allelic, genotypic and haplotypic frequencies for the selected markers.

Theoretical Framework: The study hypothesis centers on the need to validate a cost-effective reduced SNP panel, enhance genotyping accuracy, and support selective breeding against scrapie in Brazilian sheep.

Method: The methodology adopted comprises a reduced SNP panel, with markers associated with scrapie, designed to genotype DNA samples of Brazilian sheep breeds.

Results and Discussion: The panel achieved a success rate of 73%, as out of the 15 genotyped markers, only four were excluded by the call rate. Moreover, 73% (845) of the initial 1,152 samples were successfully genotyped. Analyzing the three most important PRNP polymorphisms, we found that genotype ARQ/ARQ, associated with susceptibility to scrapie, was the most frequent in all breeds. In contrast, genotype ARR/ARR (resistance) was found only in the BBGA (4%).
Research Implications: Overall, the low-density SNP panel can be a rapid, dependable, and cost-effective tool for enhancing genetic selection in Brazilian sheep. However, further technology optimization is necessary, which can be achieved by excluding and replacing non-functional markers.

Originality/Value: This study presents valuable insights by providing a cost-effective, validated genotyping tool tailored to SNP markers associated with scrapie in Brazilian sheep, which can streamline genetic selection in breeding programs.
Sustainable Practices in Organic Aquaculture: Scientometrics of Relevant Studies
Authors: Miranda Eva Barros , Luiz Junior Olavo José , Feiden Aldi 
Published: December 2024

Objective: This study carried out a systematic analysis of scientific production on organic aquaculture, with the aim of identifying the most relevant contributions and the main trends in the literature on the subject.

Theoretical Framework: Organic aquaculture is considered a sustainable and innovative practice, aimed at producing high quality food with a focus on environmental preservation and animal welfare. However, challenges such as high certification costs and unequal access to technologies limit its expansion.

Method: The research used the Methodi Ordinatio methodology to rank the most relevant articles and bibliometric analysis with the VOSviewer software to map co-authorship networks and identify thematic areas. A total of 100 articles from the Scopus database were analyzed, focusing on the 10 best-ranked articles.

Results and Discussion: The analysis revealed four main areas of interest: (1) technology and innovation; (2) consumer dynamics and marketing; (3) sustainability and (4) the panorama and challenges of organic aquaculture. The results show that despite advances in developed countries, economic and regulatory barriers hinder the adoption of organic practices in developing countries.

Research Implications: This study contributes to the understanding of the main gaps and trends in the field of organic aquaculture, offering subsidies for the development of public policies and market strategies that strengthen the sector.

Originality/Value: By combining quantitative bibliometric methodologies and qualitative analysis, the study offers a comprehensive view of the state of the art on organic aquaculture, highlighting the most relevant scientific contributions and the challenges to be faced.
Hepatic Encephalopathy Scoring Model in Hepatic Cirrhosis Based on Clinical and Laboratory Parameter
Authors: Pamungkas Kadek Mercu Narapati , Lesmana Dewi Putu Itta Sandi , Dewi Ni Luh Putu Yunia , Kharisma Dewi Ni Nyoman Gita , Sindhughosa Dwijo Anargha , Mariadi Ketut 
Published: December 2024

Background: Hepatic Encephalopathy (HE) is a serious complication with a wide spectrum of clinical symptoms, from minimal changes to profound coma. HE is hard to diagnose without advanced laboratory parameters such as ammoni. This study aims to develop a scoring model to diagnose HE using clinical and laboratory parameters. Methods: An analytical cross-sectional study collected data from 96 hospitalized patients with liver cirrhosis from November 2021 to January 2022. Employing multivariate logistic regression analysis, the study aimed to identify autonomous factors associated with HE. Each significant variable was used to calculate patient probabilities. The score for each variable was computed utilizing the (B/SE)/lowest(B/SE) formula, demonstrating robust discriminatory capability. The scoring model was formulated and evaluated based on its sensitivity and specificity.Results: Nineteen point eight percent, equivalent to ninenteen patients, were admitted with HE. The scoring model was crafted based on nineteen variables. There were four significant variables in this model: Aspartate Aminotransferase (AST) (p=0.01), Total Bilirubin (p=0.007), Fibrosis-4-Index (FIB-4) (p=0.014), and Ascites (p=0.016). Each variable was scored as 1 for AST, -1 for total bilirubin, 1 for FIB-4-index, and 1 for Ascites. The probability was 2%, 14.2%, 57%, 91.4%, and 50%, following the total score of -1, 0, 1, 2, and 3, respectively. The sensitivity and specificity of the scoring model were 68.4% and 85.3%, respectively (AUC=84.7%).Conclusion: Daily laboratory and clinical manifestations related to hepatic cirrhosis could give a clue to diagnosing hepatic encephalopathy.Keywords: Clinical parameters, hepatic encephalopathy, laboratory parameters, scoring, scoring model
STRATEGI PENDIDIK DALAM MENGEMBANGKAN KEMAMPUAN KOGNITIF ANAK PADA MASA BELAJAR DARI RUMAH
Authors: Afipah Afipah , Koenarso Dyah Ageng Pramesty 
Published: December 2024

The purpose in the study was to find out the teacher's strategy in developing children's cognitive abilities during the learning period from home period in RA Islam Terpadu Ta'dIbul Amin Banjarmasin. This research use descriptive qualitative method. The object in this research is the teacher's strategy in developing children's cognitive abilities during the learning period from home, while the subject is 4 teachers. The data collection in this research use observation, interview and documentation. From the results of the research conducted, the strategy carried out by teachers in developing children's cognitive abilities is carried out with varied activities, and using media around the child. The use of media around children aims to make it easier for parents to follow the learning process flow, in the hope that learning objectives can be achieved effectively and efficiently.

Keywords: Cognitive Ability, Early Childhood, Learning from home, Strategy