bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Liquid Biopsies for Monitoring Disease Evolution
Authors: Tinhofer Ingeborg 
Published: June 2021

AbstractBody fluids of cancer patients have attracted increasing attention in biomedical research within the last 15 years since—as so-called liquid biopsies—they represent a non-invasive source of clinically exploitable biomarkers, including circulating tumor cells (CTCs) and cell-free tumor DNA (ctDNA). Assessment of CTCs in peripheral blood from solid cancer patients has proven useful for detection of subclinical disease which otherwise remains invisible for current staging techniques. Based on results from large cohort studies in breast and colon cancer, diagnostic tests for enumeration of CTCs have been developed which can be used for tumor staging, prognosis, and post-treatment surveillance. Circulating plasma DNA derived from Epstein–Barr or human papilloma viruses has been established as a sensitive and highly specific biomarker for early cancer detection and disease monitoring. More recently, first studies have been initiated for studying the diagnostic value of mutant variants in plasma-derived ctDNA for treatment selection, response assessment and early detection of treatment failure.Advanced Head and Neck Squamous Cell Carcinoma (HNSCC) represents a malignancy associated with locoregionally advanced stage at presentation, dismal prognosis and little improvement in treatment outcome over the past decade, especially for patients with metastatic disease. HNSCC patients might therefore benefit from incorporation of liquid biopsy-based assays in clinical management. In the following chapters, I will summarize current evidence of the diagnostic value of liquid biopsies in HNSCC and give examples of potential clinical applications.
Novel Approaches in Surgical Management: How to Assess Surgical Margins
Authors: Ferrari Marco , Montalto Nausica , Nicolai Piero 
Published: June 2021

AbstractThe concept of surgical margins was born a long time ago but still lacks a univocal and sound understanding. The current biological rationale behind the recommendations on margins management relies on two pillars: (1) the observation that groups of cancer cells can leave the macroscopic tumor and disseminate throughout adjacent tissues with different degrees of aggressiveness; (2) the belief that removal of all (or most of) cancer cells can cure the patient. However, this background is undermined by some pieces of evidence. For instance, it has been proven that tissues surrounding cancer often bear precancerous traits, which means that cutting through non-cancerous tissues does not equate to cut through healthy tissues. The head and neck exquisitely poses a number of challenges in the achievement of negative margins, with special reference to anatomical complexity, high density in relevant structures, and unique histological heterogeneity of cancers. Currently, intraoperative margins evaluation relies on surgeons’ sight, palpation, ability to map tumor extension on imaging, and knowledge of anatomy, with some optical imaging technologies aiding the delineation of the mucosal margins of excision. Frozen sections are currently used to intraoperatively evaluate margins, yet with debate on whether and how this practice should be performed. Future perspectives on improvement of margins control are threefold: research is oriented towards refinements of understanding of cancers local progression, implementation of technologies to intraoperatively render tumor extension, and employment of optical imaging modalities capable of detecting foci of residual tumor in the surgical bed.
History of the European-Japanese Cerebrovascular Congress
Authors: Tsukahara Tetsuya 
Published: June 2021

AbstractThe European-Japanese Cerebrovascular Congress originally started as a Swiss-Japanese joint conference on cerebral aneurysm. The Congress was held in Zürich, Switzerland, from 5–7 May 2001 with Prof. Y. Yonekawa of Zürich and Prof. Y. Sakurai of Sendai as the presidents.Three years later, in July of 2004, the second meeting was held at Zürich again with wide-ranging conference topics on cerebral stroke surgery.The third meeting at Zürich in 2006 was the key congress for future development. The conference was expanded to the European-Japanese Joint Conference for Stroke Surgery.As the year of 2006 was the 70th Anniversary of the Department of Neurosurgery, University Hospital Zürich, Prof. Krayenbühl, Prof. Yasargil, and Prof. Yonekawa introduced the impressive history of the Department of Neurosurgery at the conference.At the fourth European-Japanese Joint Conference on Stroke Surgery we moved from Zürich to the Nordic city of Helsinki, with Prof. Juha Hernesniemi as the conference president.The fifth joint conference was held at Düsseldolf am Rein with Prof. Hans-Jakob Steiger as the Conference president.The sixth conference, named “The European-Japanese Stroke Surgery Conference” (EJSSC), was held in Utrecht, The Netherlands. Professor Luca Regli and Prof. Gabriel Rinkel were the conference presidents.The seventh European-Japanese Stroke Surgery Conference (EJSSC) was held in Verona, Italy with the presidents Prof. Alberto Pasqualin and Prof. Giampietro Pinna.The eighth European-Japanese Cerebrovascular Congress (EJCVC) came back to Zürich in the year 2016 with Prof. Luca Regli as the president.The ninth European-Japanese Cerebrovascular Congress (EJCVC) was held in the historical room of Grande Ospedale Metropolitano Niguarda Milan, Italy, with Prof. Marco Cenzato as the president.The tenth European-Japanese Cerebrovascular Congress (EJCVC) will be held in Kyoto. It will be the first meeting of the EJCVC in Japan.Publication of the proceeding books of the conference as supplements of ACTA Neurochirurgica is one of the main reasons that we have been able to continue this conference for almost 20 years. We sincerely thank Prof. Steiger for his continuous and generous cooperation as the series Editor of ACTA Neurochirurgica.
Complications of Endovascular Treatment of Intracranial Dural Arteriovenous Fistulas
Authors: Kuwayama Naoya , Akioka Naoki 
Published: June 2021

AbstractAims: To report the endovascular treatment and complications of intracranial and spinal dural arteriovenous (AV) fistulas. Methods: A retrospective analysis of 863 cases with dural AV fistulas was completed in the nationwide registry study of the Japanese Society of Neuroendovascular Therapy. Results: Treatments included transarterial/transvenous embolization (TAE/TVE), open surgery, stereotactic radiation, and their combinations. Modified Rankin Scale 0 (mRS-0) of the patients before and after treatment were 21% and 68%, and mRS 0-1were 69% and 86%, respectively. Mortality rate after treatment was 0.6%. Major complications of TAE and TVE were cranial nerve palsy and cerebral infarction. Conclusions: Major complications resulted from occlusion of vasa nervosum and material migration via dangerous intracranial and extracranial arterial anastomosis.
Outcomes of Balloon Angioplasty and Stenting for Symptomatic Intracranial Atherosclerotic Stenosis at a High Volume Center
Authors: Ueda Toshihiro , Takada Tatsuro , Usuki Noriko , Takaishi Satoshi , Tokuyama Yoshiaki , Tatsuno Kentaro , Hamada Yuki , Yoshie Tomohide 
Published: June 2021

AbstractPurpose: This study investigated the periprocedural complication rates, long-term outcome, and restenosis of endovascular treatment for intracranial atherosclerotic stenosis (ICS) at our hospital.Methods: We retrospectively analyzed the clinical data of 217 patients comprising 256 endovascular treatments for high-grade symptomatic ICS. The lesion was located in the internal carotid artery in 77, the middle cerebral artery in 111, the basilar artery in 29, and the vertebral artery in 39. Patients were divided into two groups, before (early-phase group, 1999–2013) and after approval of Wingspan (late-phase group, 2014–2017).Results: In the early-phase group (n = 163), 157 lesions were treated by balloon angioplasty and 31 (17%) by coronary stenting. In the late-phase group (n = 54), 33 lesions were treated by balloon angioplasty and 35 (52%) by Wingspan stenting. Overall technical success rates were 96% in the balloon angioplasty and 100% in stenting groups. The 30-day rate of stroke, TIA, and death were 4.8% in the early-phase group and 4.4% in the late-phase group. There was one minor stroke and two TIAs during the follow-up period in the late-phase group.Conclusions: Endovascular treatment for symptomatic ICS in this study appeared to be safe and effective if patients are properly selected. However, future well-designed randomized trials with different techniques and modified patients selection criteria are certainly warranted.
Fire Following Earthquake—The Potential in Istanbul
Authors: Scawthorn C. 
Published: June 2021

AbstractFire following earthquake is a little recognized risk in seismic regions with significant wood building inventories. Methods exist for quantifying this risk, and examples are provided in this chapter for San Francisco, Istanbul and Montreal. There are many opportunities for reducing this risk, and examples are provided regarding reducing fire station vulnerability and improving emergency firefighting water supply. Once accomplished however, vigilance is required to maintain these mitigation measures.
Risk Oriented Earthquake Hazard Assessment: Influence of Spatial Discretisation and Non-ergodic Ground-Motion Models
Authors: Stafford Peter J. 
Published: June 2021

AbstractThree important aspects of ground-motion modelling for regional or portfolio risk analyses are discussed. The first issue is the treatment of discretisation of continuous ground-motion fields for generating spatially correlated discrete fields. Shortcomings of the present approach in which correlation models based upon point estimates of ground motions are used to represent correlations within and between spatial regions are highlighted. It is shown that risk results will be dependent upon the chosen spatial resolution if the effects of discretisation are not adequately treated. Two aspects of non-ergodic groundmotion modelling are then discussed. Correlation models generally used within risk modelling are traditionally based upon very simple partitioning of ground-motion residuals. As regional risk analyses move to non-ergodic applications where systematic site effects are considered, these correlation models (both inter-period and spatial models) need to be revised. The nature of these revisions are shown herein. Finally, evidence for significantly reduced between-event variability within earthquake sequences is presented. The ability to progressively constrain location and sequence-dependent systematic offsets from ergodic models as earthquake sequences develop can have significant implications for aftershock risk assessments.
Unpacking the New Complexities of EU–Turkey Relations: Merging Theories, Institutions, and Policies
Authors: Turhan Ebru , Reiners Wulf 
Published: June 2021

AbstractThis chapter presents the rationale, objectives, and structure of this volume and introduces the reader to the new complexities that epitomize EU–Turkey relations. To this end, it provides a set of guiding questions for the volume, offers a systematic overview of the major milestones in the EU–Turkey relationship, and classifies the key determinants of these developments under three categories: multilateral frameworks and external crises, internal EU and Turkish domestic developments, and EU–Turkey bilateral processes. The chapter then introduces the three-dimensional approach of the volume that brings together the analytical lenses of (1) theories and concepts, (2) institutions, and (3) policies based on a comprehensive survey of both key primary sources and academic literature dealing with the relationship. In a final step, the chapter presents the ensuing fifteen contributions to the volume.
Turkey as a Special and (Almost) Dead Case of EU Enlargement Policy
Authors: Lippert Barbara 
Published: June 2021

AbstractThis chapter analyzes the relationship between the EU and Turkey from the perspective of the EU’s enlargement policy. It sets out to explain the extent to which Turkey represents a special and difficult case for EU enlargement policy and addresses the following aspects of the relationship. First, the overall concepts, motives, and criteria of EU enlargement are introduced. The second section deals with critical questions that Turkey poses for the EU in this respect. The third section outlines how specific features of the EU–Turkey relationship have played out from the onset and during accession negotiations. While no full or detailed account of the history of relations is given, the focus is on those issues that make Turkey a special and (almost) dead case of EU enlargement policy. Finally, a brief outlook on the future of bilateral relations is presented which shows the persistent ambivalences that characterize Brussels’ relationship with Ankara.
Constructivist Approaches to EU–Turkey Relations
Authors: Aydın-Düzgit Senem , Rumelili Bahar 
Published: June 2021

AbstractThis chapter provides a critical survey of constructivist approaches to EU–Turkey relations, which place significance on the role of norms, identities, discourse, ideas, and values in the relationship. It outlines the main contours of the constructivist school of thought in International Relations (IR) with a discussion of how the different variants of constructivism can be applied to the study of the case of EU–Turkey relations. It is followed by an illustrative survey of the academic contributions in the field of EU–Turkey relations that base their accounts on constructivist theoretical premises in three periods: 1997–1999, 2000–2010, and 2011–2020. The chapter concludes with a discussion of potential areas for further constructivist research on EU–Turkey relations.
Europeanization and EU–Turkey Relations: Three Domains, Four Periods
Authors: Alpan Başak 
Published: June 2021

AbstractEuropeanization is deservedly one of the most popular yet most volatile buzzwords for Turkish politics and EU–Turkey relations. This chapter takes stock of the Europeanization literature and examines the EU–Turkey relationship by referring to particular mechanisms and variants of Europeanization. The main argument is that Europeanization is a versatile and complex process covering vast areas of policy, politics, and polity, intertwined with larger domestic, regional, and global processes, which is not limited to Turkey’s EU accession. The analysis refers to particular mechanisms and variants of Europeanization in four different phases between 1963 and early 2020: In the first period, ‘Europeanization as rapprochement’, Turkey’s age-old Westernization project was consolidated through Europeanization. In the second period, ‘Europeanization as democratic conditionality’, there has been strong interest in the impact of Europeanization on particular aspects of domestic issues through conditionality and the EU’s role as a ‘democratization anchor’. In the third period, ‘Europeanization as retrenchment’, and the fourth period, ‘Europeanization as denial’, ‘Europe’ was no longer the lingua franca in the Turkish political landscape, a trend that is also associated with a ‘de-Europeanization’ turn in the literature. This does not mean that ‘Europe’ completely disappeared from domestic policy orientations, political debates, and identity negotiations. Rather, Ankara used ‘Europe’ strategically to justify actions that were criticized by the EU.
Rhetorical Entrapment in EU–Turkey Relations
Authors: Schimmelfennig Frank 
Published: June 2021

AbstractThis chapter describes and applies the rhetorical action approach to EU–Turkey relations. Generally, rhetorical entrapment denotes the mechanism by which actors are compelled to act in conformance with their prior argumentative commitments. In the context of EU enlargement, member states have committed themselves to enlargement norms and promises in line with the fundamental purpose and values of the EU (such as pan-European community building, liberal democracy and supranationalism). Rhetorical entrapment played an important role in bringing about Eastern enlargement when the Eastern European countries faced significant resistance among the old member states. Finally, the chapter analyzes the rhetorical entrapment mechanism in the accession process of Turkey, which had an even more unfavorable starting position. As long as Turkey progressed on meeting the official political criteria for EU membership, however, the opponents of Turkish membership were bound by their normative commitment and felt compelled to decide in favor of accession negotiations. The rhetorical entrapment mechanism also elucidates why accession negotiations began to stall soon after their start. The opponents of Turkish membership were released from the rhetorical trap when Turkey failed to heed its own promises and honor its own obligations as a candidate state.
SU(3) analysis of four-quark operators: K → ππ and vacuum matrix elements
Authors: Pich A. , Rodríguez-Sánchez A. 
Published: June 2021

AbstractHadronic matrix elements of local four-quark operators play a central role in non-leptonic kaon decays, while vacuum matrix elements involving the same kind of operators appear in inclusive dispersion relations, such as those relevant inτ-decay analyses. Using an SU(3)L⊗ SU(3)Rdecomposition of the operators, we derive generic relations between these matrix elements, extending well-known results that link observables in the two different sectors. Two relevant phenomenological applications are presented. First, we determine the electroweak-penguin contribution to the kaon CP-violating ratioε′/ε, using the measured hadronic spectral functions inτdecay. Second, we fit our SU(3) dynamical parameters to the most recent lattice data onK→ππmatrix elements. The comparison of this numerical fit with results from previous analytical approaches provides an interesting anatomy of the ∆I=$$ \frac{1}{2} $$12enhancement, confirming old suggestions about its underlying dynamical origin.
Cascade of phase transitions in a planar Dirac material
Authors: Kanazawa Takuya , Kieburg Mario , Verbaarschot Jacobus J.M. 
Published: June 2021

Abstract
We investigate a model of interacting Dirac fermions in 2 + 1 dimensions with M flavors and N colors having the U(M)×SU(N ) symmetry. In the large-N limit, we find that the U(M) symmetry is spontaneously broken in a variety of ways. In the vacuum, when the parity-breaking flavor-singlet mass is varied, the ground state undergoes a sequence of M first-order phase transitions, experiencing M + 1 phases characterized by symmetry breaking U(M)→U(M − k)×U(k) with k ∈ {0, 1, 2, · · · , M}, bearing a close resemblance to the vacuum structure of three-dimensional QCD. At finite temperature and chemical potential, a rich phase diagram with first and second-order phase transitions and tricritical points is observed. Also exotic phases with spontaneous symmetry breaking of the form as U(3)→U(1)3, U(4)→U(2)×U(1)2, and U(5)→U(2)2×U(1) exist. For a large flavor-singlet mass, the increase of the chemical potential μ brings about M consecutive first-order transitions that separate the low-μ phase diagram with vanishing fermion density from the high-μ region with a high fermion density.
Renormalization of the C2HDM with FeynMaster 2
Authors: Fontes Duarte , Romão Jorge C. 
Published: June 2021

Abstract
We present the one-loop electroweak renormalization of the CP-violating 2-Higgs-Doublet Model with softly broken ℤ2 symmetry (C2HDM). The existence of CP violation in the scalar sector of the model leads to a quite unique process of renormalization, since it requires the introduction of several non-physical parameters. The C2HDM will thus have more independent counterterms than independent renormalized parameters. As a consequence, different combinations of counterterms can be taken as independent for the same set of independent renormalized parameters. We compare the behaviour of selected combinations in specific NLO processes, which are assured to be gauge independent via a simple prescription. FeynMaster 2 is used to derive the Feynman rules, counterterms and one-loop processes in a simultaneously automatic and flexible way. This illustrates its use as an ideal tool to renormalize models such as the C2HDM and investigate them at NLO.
Counting the Number of τ-Exceptional Sequences over Nakayama Algebras
Authors: Msapato Dixy 
Published: June 2021

AbstractThe notion of a τ-exceptional sequence was introduced by Buan and Marsh in (2018) as a generalisation of an exceptional sequence for finite dimensional algebras. We calculate the number of complete τ-exceptional sequences over certain classes of Nakayama algebras. In some cases, we obtain closed formulas which also count other well known combinatorial objects, and exceptional sequences of path algebras of Dynkin quivers.
The introduction of the European Caucasotachea vindobonensis (Gastropoda: Helicidae) in North America, its origin and its potential range
Authors: Hausdorf Bernhard , Parr Matt , Shappell Laura J. , Oldeland Jens , Robinson David G. 
Published: June 2021

AbstractWe report the introduction of the central and eastern European helicid land snail Caucasotachea vindobonensis in North America. It was first recorded from Rensselaer County in the state of New York in 2015 by a community scientist. From 2016 to 2020, 14 additional occurrences in Rensselaer County, neighbouring Albany County and an imprecisely localized site in the Adirondack Mountains were recorded by community scientists. In 2020, the species was newly recorded at two sites in Schoharie County, NY, and at three sites in Québec, one of them approximately 700 km to the north of the initial record. Partial mitochondrial cox1 sequences from Rensselaer differ from an eastern Ukrainian haplotype only in a single substitution. Therefore, a Ukrainian origin for this introduction is likely, although not certain: the Rensselaer haplotype also differs in only two substitutions from a more widespread haplotype known from Ukraine, Hungary, Slovakia, Czechia, Serbia, and Bulgaria. An environmental niche model of the species based on occurrence data from central and eastern Europe indicated that a large region from the northern east coast to the midwestern United States is suitable for C. vindobonensis. The Canadian occurrences may indicate that the North American lineage is able to survive colder winters than predicted by the environmental niche model. Caucasotachea vindobonensis is not listed as a pest in Europe and it is unlikely to become an agricultural pest in North America as it prefers rotting plant material over living parts of plants, but its impact on native organisms can hardly be predicted.