bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KEPEMIMPINAN, KETERLIBATAN KARYAWAN DAN KEPUASAN KERJA TERHADAP KESIAPAN UNTUK BERUBAH DALAM MENGHADAPI PERUBAHAN ORGANISASI
Authors: Susyanto Hendro 
Published: January 2021

Di dalam persaingan penjualan semen di pangsa pasar Indonesia yang semakin ketat dan kelebihan pasokan semen dibandingkan permintaan, manajemen PT Holcim Indonesia melakukan perubahan organisasi untuk meningkatkan tingkat kompetensi terhadap para competitor yang semakin banyak baik dari dalam negeri maupun luar negeri. Perubahan yang dilakukan diantaranya penggantian manajemen puncak (CEO dan BOD), perubahan visi dan misi perusahaan serta pengurangan karyawan pada tahun 2014 – 2016. Hal ini berdampak pada kinerja perusahaan khususnya operasional pabrik Cilacap yang mengalami penurunan kinerja selama proses perubahan organisasi tersebut. Berbagai kebijakan pengembangan organisasi telah dilakukan oleh manajemen untuk meningkatkan kesiapan karyawan untuk berubah dan jika mengacu pada parameter operasi pabrik, terjadi peningkatan kinerja setelah tahun ke empat (2017). Tujuan penelitian ini adalah untuk mengetahui tingkat kesiapan karyawan untuk berubah yang dipengaruhi oleh faktor kepemimpinan (transformasional dan transaksional), keterlibatan karyawan, tingkat kepuasan kerja di lingkungan PT Holcim Tbk pabrik cilacap. Hasil penelitian ini menunjukan bahwa karyawan PT Holcim Indonesia pabrik Cilacap memiliki kesiapan untuk berubah yang tinggi dan hal tersebut dipengaruhi secar positif oleh keterlibatan karyawan dan kepuasan kerja, sedangkan faktor kepemimpinan tidak berpengaruh langsung terhadap kesiapan untuk berubah tetapi melalui variable intervening yaitu kepuasan kerja dan keterlibatan karyawan.
Pengaruh Manajemen Kelas, Kesiapan Belajar dan Pemanfaatan Internet Terhadap Prestasi Belajar Ekonomi Siswa Kelas X IPS SMA Negeri 4 Purwokerto
Authors: Mutmainah Siti , Sunarko Bambang , Jati Eling Purwanto 
Published: January 2021

Penelitian ini merupakan penelitian dengan pendekatan deksriptif kuantitatif yang bertujuan untuk mengetahui pengaruh manajemen kelas, kesiapan belajar dan pemanfaatan internet terhadap prestasi belajar ekonomi siswa kelas X IPS SMA Negeri 4 Purwokerto. Populasi dalam penelitian ini yaitu seluruh siswa kelas X IPS SMA Negeri 4 Purwokerto sebanyak 141 siswa. Teknik pengambilan sampling yaitu simple random sampling dengan jumlah sampel sebanyak 105 responden.
Teknik analisis data yang digunakan dalam penelitian ini adalah analisis regresi linear berganda. Penelitian ini menghasilkan suatu kesimpulan: 1) Manajemen kelas berpengaruh positif terhadap prestasi belajar ekonomi siswa kelas X IPS SMA Negeri 4 Purwokerto; 2) Kesiapan belajar berpengaruh positif terhadap prestasi belajar ekonomi siswa kelas X IPS SMA Negeri 4 Purwokerto; 3) Pemanfaatan internet berpengaruh positif terhadap prestasi belajar ekonomi siswa kelas X IPS SMA Negeri 4 Purwokerto; 4) Manajemen kelas, kesiapan belajar dan pemanfaatan internet secara simultan berpengaruh terhadap prestasi belajar ekonomi siswa kelas X IPS SMA Negeri 4 Purwokerto.

Kata kunci : manajemen kelas, kesiapan belajar, pemanfaatan internet, prestasi belajar
The Association of Neoadjuvant Systemic Treatment on Hormone Receptor and Her2 Expression in Breast Cancer
Authors: MacFaul William , D Hughesa T Michael , Hitosd Kerry , Pathmanathane Nirmala , Nguia Nicholas K 
Published: January 2021

Background: Pathological complete response (pCR) following neoadjuvant systemic treatment(NAST) for breast cancer is associated with improved prognosis; however, a large proportion of patients have residual disease. Oestrogen Receptor (ER) and HER2 status have been shown to affect likelihood of achieving pCR, with ER positive tumors being more treatment resistant. As hormone receptor status is heterogeneous within tumors, we postulated that, following NAST, ER expression would change in patients with residual disease, as the ER negative cells within the tumor are more treatment sensitive. Methods: A retrospective case series of patients treated with NAST prior to surgery at our institution was conducted. Information collected included demographic data, tumor grade, hormone receptor and HER2 status both before and after treatment, and pCR rates.Results: Of the 44 patients included, half achieved pCR. HER2 status (P=0.01), and subtype (P=0.008) were significantly associated with pCR. HER2 positive/ER negative tumors were most likely to undergo pCR. Approximately 80% of residual disease was ER positive. Higher levels of ER expression were also associated with increasing residual cancer burden (RCB) class (P=0.037). There was no trend between change in ER or HER2 expression following NAST. Median change in ER expression was 80% to 90% (P= 0.89), HER2 intensity changed from 3.0 to 2.2 (P=0.67) following treatment. Conclusion: Consistent with the literature, we have shown associations between ER and HER2 status and PCR, and between ER expression and residual disease burden. Our study was not able to demonstrate a significant trend in hormone and HER2 expression.
Managing Marine Environmental Pollution using Artificial Intelligence
Authors: Agarwala NItin 
Published: January 2021

The marine environment has deteriorated to an extent that it has begun to impact human health and the planet itself. The primary cause of this deterioration as identified are, an increasing population, the industrial revolution and the increased use of fossil fuels. While the damage done to the environment cannot be undone, the impact can be lessened by better understanding the ocean and monitoring future pollution using technology. Such an effort will help achieve sustainability as laid out by the Sustainable Development Goals 2030 of the United Nations. The article aims to provide an insight into one such technology, namely ‘Artificial Intelligence (AI)’, being developed to understand and monitor the marine pollution. In doing so the article will discuss the emerging opportunities and risks associated with the use of AI in managing marine environmental pollution through sustainability. To strengthen the argument, use-cases of AI in the marine environment and their scalability are discussed.
STUDI PENGUKURAN KONSTANTA DIELEKTRIK KAIN RAJUT PAKAN POLIESTER DAN KATUN MENGGUNAKAN METODE KAPASITANSI PERANGKAT KAPASITOR PLAT SEJAJAR
Authors: Munandar Taufik , Putra Valentinus Galih Vidia , Wardiningsih Wiah 
Published: January 2021

Pada penelitian ini telah dilakukan penentuan konstanta dielektrik material kain rajut pakan menggunakan metode kapasitansi perangkat kapasitor plat sejajar. Kain rajut pakan telah dibuat dengan menggunakan mesin rajut datar Stoll tipe CMS 530HP. Enam sampel kain rajut poliester dan katun telah dibuat pada mesin rajut terkomputerisasi dengan kerapatan yang berbeda-beda. Terdapat tiga jenis kerapatan kain rajut yang telah dibuat pada penelitian ini. Pengukuran kapasitansi terdiri dari perangkat mikrokontroler Arduino Uno dan susunan seri resistor-kapasitor (RC). Hasil penelitian menunjukan bahwa kain rajut katun NP10 memiliki konstanta dielektrik yang lebih besar dibandingkan dengan kain poliester pada struktur kain yang sama. Hasil menunjukan korelasi yang cukup baik antara hasil prediksi dan eksperimen pada pengukuran kapasitansi. Terdapat enam bahan dielektrik yang ditentukan dengan hasil dari yang terbesar sampai yang terkecil berturut-turut yaitu kain rajut katun NP 10 (22,8874 + 4,6388), kain rajut katun NP 11 (21,4717 + 3,8064), kain rajut katun NP 12 (17,8721 + 2,3233), kain rajut poliester NP 10 (9,7751 + 2,4922), kain rajut poliester NP 11 (8,8282 + 0,9360) dan kain rajut poliester NP 12 (8,4358 + 1,1849). Telah ditemukan hubungan antara parameter kerapatan kain kain rajut pakan terhadap nilai konstanta dielektrik terukur. Kata kunci—kain rajut pakan, poliester, katun, kerapatan kain, konstanta dielektrik, kapasitor plat-sejajar. ABSTRACT This paper describes the dielectric measurement of weft knitted fabric using parallel-plate capacitance method. The weft knitted fabric were fabricated using weft knit machine Stoll CMS 530HP. Six different samples of polyester and cotton knitted fabric were fabricated by computerized flat knitting machine. There are consist of three types of density which made on this study. The capacitance measurement were consist of Arduino Uno microcontroller and a series of resistor-capacitor (RC). The result of this research indicates that NP10 cotton knitted fabric has higher dielectric constant than the polyester knitted fabric, with similar structure respectively. There are six fabric dielectric materials that are determined with the results from the largest to the smallest in a row namely NP 10 cotton knitted fabric (22,8874 + 4,6388), NP 11 cotton knitted fabric (21,4717 + 3,8064), NP 12 cotton knitted fabric (17,8721 + 2,3233), NP 10 polyester knitted fabric (9,7751 + 2,4922), NP 11 polyester knitted fabric (8,8282 + 0,9360) and NP 12 polyester knitted fabric (8,4358 + 1,1849). It has been found the correlation between the fabric density and the permittivity of the weft knitted fabric. Keywords—weft knitted fabric, polyester, cotton, fabric density, dielectric constant, parallel-plate capacitor.
PENGEMBANGAN E-MODUL BERBASIS HOTS BERBANTUAN FLIPBOOK MARKER SEBAGAI BAHAN AJAR ALTERNATIF SISWA SMA
Authors: Puspitasari Rina , Hamdani Dedy , Risdianto Eko 
Published: January 2021

ABSTRAK Penelitian ini bertujuan untuk mengetahui karakteristik dan kelayakan modul yang dikembangkan berbasis HOTS berbantuan Flipbook Marker sebagai bahan ajar alternatif siswa sekolah menengah atas.. Penelitian ini dilakukan dengan desain 4-D yang memiliki empat tahap yaitu tahap Define (Pendefinisian), Design (Perancangan), Develop (Pengembangan, dan Desseminate (Penyebaran), namun pada penelitian ini hanya dilaksanakan sampai tahap Develop. Instrumen penilaian yang digunakan dalam penelitian ini adalah lembar validasi ahli yang berisi aspek materi, aspek bahasa dan aspek media. Berdasarkan hasil uji validasi produk oleh ahli diperoleh presentase skor 84,7% untuk aspek materi, 81,0% untuk aspek bahasa, dan 81,2% untuk aspek media, sehingga total rata-rata skor adalah 82,3% termasuk ke dalam kategori sangat valid. Dengan demikian modul elektronik (e-modul) berbasis HOTS berbantuan Flipbook Marker menjadi produk jadi yang layak digunakan. Kata kunci: e-modul, HOTS, Flipbook Marker ABSTRACT This research aimed to determine the characteristics and the feasibility of the module developed based on HOTS aided by Flipbook Marker as an alternative teaching material for high school students.This research was carried out with a 4-D design that had four stages, namely the Define, Design, Develop and Desseminate stages, but in this study it was only carried out until the Develop stage. This is an expert validation sheet that contains material aspects, language aspects and media aspects Based on the results of the product validation test by the expert, a percentage score of 84.7% for the material aspect, 81.0% for the language aspect, and 81.2% for the media aspect , so that the total average score is 82.3% included in the very valid category, so the electronic module (e-module) based on HOTS aided by Flipbook Marker becomes a finished product that is suitable for use. Keywords: e-module, HOTS, Flipbook Marker
MicroRNA-30e-5p Regulates SOCS1 and SOCS3 During Bacterial Infection
Authors: Mishra Richa , Krishnamoorthy Pandikannan , Kumar Himanshu 
Published: January 2021

Host innate immunity is the major player against continuous microbial infection. Various pathogenic bacteria adopt the strategies to evade the immunity and show resistance toward the various established therapies. Despite the advent of many antibiotics for bacterial infections, there is a substantial need for the host-directed therapies (HDTs) to combat the infection. HDTs are recently being adopted to be useful in eradicating intracellular bacterial infection. Changing the innate immune responses of the host cells alters pathogen’s ability to reside inside the cell. MicroRNAs are the small non-coding endogenous molecules and post-transcriptional regulators to target the 3’UTR of the messenger RNA. They are reported to modulate the host’s immune responses during bacterial infections. Exploiting microRNAs as a therapeutic candidate in HDTs upon bacterial infection is still in its infancy. Here, initially, we re-analyzed the publicly available transcriptomic dataset of macrophages, infected with different pathogenic bacteria and identified significant genes and microRNAs common to the differential infections. We thus identified and miR-30e-5p, to be upregulated in different bacterial infections which enhances innate immunity to combat bacterial replication by targeting key negative regulators such as SOCS1 and SOCS3 of innate immune signaling pathways. Therefore, we propose miR-30e-5p as one of the potential candidates to be considered for additional clinical validation toward HDTs.
A Hiatus Obscures the Early Evolution of Modern Lineages of Bony Fishes
Authors: Romano Carlo 
Published: January 2021

About half of all vertebrate species today are ray-finned fishes (Actinopterygii), and nearly all of them belong to the Neopterygii (modern ray-fins). The oldest unequivocal neopterygian fossils are known from the Early Triassic. They appear during a time when global fish faunas consisted of mostly cosmopolitan taxa, and contemporary bony fishes belonged mainly to non-neopterygian (“paleopterygian”) lineages. In the Middle Triassic (Pelsonian substage and later), less than 10 myrs (million years) after the Permian-Triassic boundary mass extinction event (PTBME), neopterygians were already species-rich and trophically diverse, and bony fish faunas were more regionally differentiated compared to the Early Triassic. Still little is known about the early evolution of neopterygians leading up to this first diversity peak. A major factor limiting our understanding of this “Triassic revolution” is an interval marked by a very poor fossil record, overlapping with the Spathian (late Olenekian, Early Triassic), Aegean (Early Anisian, Middle Triassic), and Bithynian (early Middle Anisian) substages. Here, I review the fossil record of Early and Middle Triassic marine bony fishes (Actinistia and Actinopterygii) at the substage-level in order to evaluate the impact of this hiatus–named herein the Spathian–Bithynian gap (SBG)–on our understanding of their diversification after the largest mass extinction event of the past. I propose three hypotheses: 1) the SSBE hypothesis, suggesting that most of the Middle Triassic diversity appeared in the aftermath of the Smithian-Spathian boundary extinction (SSBE; ∼2 myrs after the PTBME), 2) the Pelsonian explosion hypothesis, which states that most of the Middle Triassic ichthyodiversity is the result of a radiation event in the Pelsonian, and 3) the gradual replacement hypothesis, i.e. that the faunal turnover during the SBG was steady and bony fishes were not affected by extinction events subsequent to the PTBME. Based on current knowledge, hypothesis three is favored herein, but further studies are necessary to test alternative hypotheses. In light of the SBG, claims of a protracted diversification of bony fishes after the PTBME should be treated with caution.
Construction of an RNA-Binding Protein-Related Prognostic Model for Pancreatic Adenocarcinoma Based on TCGA and GTEx Databases
Authors: Wen Xin , Shao Zhiying , Chen Shuyi , Wang Wei , Wang Yan , Jiang Jinghua , Ma Qinggong , Zhang Longzhen 
Published: January 2021

Background: Recently, RNA-binding proteins (RBPs) were reported to interact with target mRNA to regulate gene posttranscriptional expression, and RBP-mediated RNA modification can regulate the expression and function of proto-oncogenes and tumor suppressor genes. We systematically analyzed the expression of RBPs in pancreatic adenocarcinoma (PAAD) and constructed an RBP-associated prognostic risk model.Methods: Gene expression data of normal pancreatic samples as well as PAAD samples were downloaded from TCGA-PAAD and GTEx databases. Wilcoxon test and univariate Cox analysis were, respectively, applied to screen differential expression RBPs (DE-RBPs) and prognostic-associated RBPs (pRBPs). Functional enrichment was analyzed by GO, KEGG, and GSEA. Protein–protein interaction (PPI) network was constructed by STRING online database. Modeling RBPs were selected by multivariate Cox analysis. Kaplan–Meier survival and Cox analysis were applied to evaluate the effects of risk score on the overall survival of PAAD patients. ROC curves and validation cohort were applied to verify the accuracy of the model. Nomogram was applied for predicting 1-, 3-, and 5-year overall survival (OS) of PAAD patients. At last, modeling RBPs were further analyzed to explore their differential expression, prognostic value, as well as enrichment pathways in PAAD.Results: RBPs (453) were differentially expressed in normal and tumor samples, besides, 28 of which were prognostic associated. DE-RBPs (453) are functionally associated with ribosome, ribonuclease, spliceosome, etc. Eight RBPs (PABPC1, PRPF6, OAS1, RBM5, LSM12, IPO7, FXR1, and RBM6) were identified to construct a prognostic risk model. Higher risk score not only predicted poor prognosis but also was an independent poor prognostic indicator, which was verified by ROC curves and validation cohort. Eight modeling RBPs were confirmed to be significantly differentially expressed between normal and tumor samples from RNA and protein level. Besides, all of eight RBPs were related with overall survival of PAAD patients.Conclusions: We successfully constructed an RBP-associated prognostic risk model in PAAD, which has a potential clinical application prospect.
Developmental Dysfunction of the Central Nervous System Lymphatics Modulates the Adaptive Neuro-Immune Response in the Perilesional Cortex in a Mouse Model of Traumatic Brain Injury
Authors: Wojciechowski Sara , Virenque Anaïs , Vihma Maria , Galbardi Barbara , Rooney Erin Jane , Keuters Meike Hedwig , Antila Salli , Koistinaho Jari , Noe Francesco M. 
Published: January 2021

RationaleThe recently discovered meningeal lymphatic vessels (mLVs) have been proposed to be the missing link between the immune and the central nervous system. The role of mLVs in modulating the neuro-immune response following a traumatic brain injury (TBI), however, has not been analyzed. Parenchymal T lymphocyte infiltration has been previously reported as part of secondary events after TBI, suggestive of an adaptive neuro-immune response. The phenotype of these cells has remained mostly uncharacterized. In this study, we identified subpopulations of T cells infiltrating the perilesional areas 30 days post-injury (an early-chronic time point). Furthermore, we analyzed how the lack of mLVs affects the magnitude and the type of T cell response in the brain after TBI.MethodsTBI was induced in K14-VEGFR3-Ig transgenic (TG) mice or in their littermate controls (WT; wild type), applying a controlled cortical impact (CCI). One month after TBI, T cells were isolated from cortical areas ipsilateral or contralateral to the trauma and from the spleen, then characterized by flow cytometry. Lesion size in each animal was evaluated by MRI.ResultsIn both WT and TG-CCI mice, we found a prominent T cell infiltration in the brain confined to the perilesional cortex and hippocampus. The majority of infiltrating T cells were cytotoxic CD8+ expressing a CD44hiCD69+ phenotype, suggesting that these are effector resident memory T cells. K14-VEGFR3-Ig mice showed a significant reduction of infiltrating CD4+ T lymphocytes, suggesting that mLVs could be involved in establishing a proper neuro-immune response. Extension of the lesion (measured as lesion volume from MRI) did not differ between the genotypes. Finally, TBI did not relate to alterations in peripheral circulating T cells, as assessed one month after injury.ConclusionsOur results are consistent with the hypothesis that mLVs are involved in the neuro-immune response after TBI. We also defined the resident memory CD8+ T cells as one of the main population activated within the brain after a traumatic injury.
Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection
Authors: Naik Shilpa , Alexander Mallika , Kumar Pavan , Kulkarni Vandana , Deshpande Prasad , Yadana Su , Leu Cheng-Shiun , Araújo-Pereira Mariana , Andrade Bruno B. , Bhosale Ramesh , Babu Subash , Gupta Amita , Mathad Jyoti S. , Shivakoti Rupak 
Published: January 2021

BackgroundRecent studies in adults have characterized differences in systemic inflammation between adults with and without latent tuberculosis infection (LTBI+ vs. LTBI−). Potential differences in systemic inflammation by LTBI status has not been assess in pregnant women.MethodsWe conducted a cohort study of 155 LTBI+ and 65 LTBI− pregnant women, stratified by HIV status, attending an antenatal clinic in Pune, India. LTBI status was assessed by interferon gamma release assay. Plasma was used to measure systemic inflammation markers using immunoassays: IFNβ, CRP, AGP, I-FABP, IFNγ, IL-1β, soluble CD14 (sCD14), sCD163, TNF, IL-6, IL-17a and IL-13. Linear regression models were fit to test the association of LTBI status with each inflammation marker. We also conducted an exploratory analysis using logistic regression to test the association of inflammatory markers with TB progression.ResultsStudy population was a median age of 23 (Interquartile range: 21–27), 28% undernourished (mid-upper arm circumference (MUAC) &lt;23 cm), 12% were vegetarian, 10% with gestational diabetes and 32% with HIV. In multivariable models, LTBI+ women had significantly lower levels of third trimester AGP, IL1β, sCD163, IL-6 and IL-17a. Interestingly, in exploratory analysis, LTBI+ TB progressors had significantly higher levels of IL1β, IL-6 and IL-13 in multivariable models compared to LTBI+ non-progressors.ConclusionsOur data shows a distinct systemic immune profile in LTBI+ pregnant women compared to LTBI− women. Data from our exploratory analysis suggest that LTBI+ TB progressors do not have this immune profile, suggesting negative association of this profile with TB progression. If other studies confirm these differences by LTBI status and show a causal relationship with TB progression, this immune profile could identify subsets of LTBI+ pregnant women at high risk for TB progression and who can be targeted for preventative therapy.