bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of Lung Cancer Among Never-Smoking Asian American, Native Hawaiian, and Pacific Islander Females
Authors: DeRouen Mindy C , Canchola Alison J , Thompson Caroline A , Jin Anqi , Nie Sixiang , Wong Carmen , Lichtensztajn Daphne , Allen Laura , Patel Manali I , Daida Yihe G , Luft Harold S , Shariff-Marco Salma , Reynolds Peggy , Wakelee Heather A , Liang Su-Ying , Waitzfelder Beth E , Cheng Iona , Gomez Scarlett L 
Published: July 2021

Abstract

Background
Although lung cancer incidence rates according to smoking status, sex, and detailed race/ethnicity have not been available, it is estimated that more than half of Asian American, Native Hawaiian, and Pacific Islander (AANHPI) females with lung cancer have never smoked.

Methods
We calculated age-adjusted incidence rates for lung cancer according to smoking status and detailed race/ethnicity among females, focusing on AANHPI ethnic groups, and assessed relative incidence across racial/ethnic groups. We used a large-scale dataset that integrates data from electronic health records from 2 large health-care systems—Sutter Health in Northern California and Kaiser Permanente Hawai’i—linked to state cancer registries for incident lung cancer diagnoses between 2000 and 2013. The study population included 1 222 694 females (n = 244 147 AANHPI), 3297 of which were diagnosed with lung cancer (n = 535 AANHPI).

Results
Incidence of lung cancer among never-smoking AANHPI as an aggregate group was 17.1 per 100 000 (95% confidence interval [CI] = 14.9 to 19.4) but varied widely across ethnic groups. Never-smoking Chinese American females had the highest rate (22.8 per 100 000, 95% CI = 17.3 to 29.1). Except for Japanese American females, incidence among every never-smoking AANHPI female ethnic group was higher than that of never-smoking non-Hispanic White females, from 66% greater among Native Hawaiian females (incidence rate ratio = 1.66, 95% CI = 1.03 to 2.56) to more than 100% greater among Chinese American females (incidence rate ratio = 2.26, 95% CI = 1.67 to 3.02).

Conclusions
Our study revealed high rates of lung cancer among most never-smoking AANHPI female ethnic groups. Our approach illustrates the use of innovative data integration to dispel the myth that AANHPI females are at overall reduced risk of lung cancer and demonstrates the need to disaggregate this highly diverse population.
Cyclic mismatch binding ligands interact with disease-associated CGG trinucleotide repeats in RNA and suppress their translation
Authors: Konieczny Patryk , Mukherjee Sanjukta , Stepniak-Konieczna Ewa , Taylor Katarzyna , Niewiadomska Daria , Piasecka Agnieszka , Walczak Agnieszka , Baud Anna , Dohno Chikara , Nakatani Kazuhiko , Sobczak Krzysztof 
Published: July 2021

AbstractFragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by a limited expansion of CGG repeats in the FMR1 gene. Degeneration of neurons in FXTAS cell models can be triggered by accumulation of polyglycine protein (FMRpolyG), a by-product of translation initiated upstream to the repeats. Specific aims of our work included testing if naphthyridine-based molecules could (i) block FMRpolyG synthesis by binding to CGG repeats in RNA, (ii) reverse pathological alterations in affected cells and (iii) preserve the content of FMRP, translated from the same FMR1 mRNA. We demonstrate that cyclic mismatch binding ligand CMBL4c binds to RNA structure formed by CGG repeats and attenuates translation of FMRpolyG and formation of nuclear inclusions in cells transfected with vectors expressing RNA with expanded CGG repeats. Moreover, our results indicate that CMBL4c delivery can reduce FMRpolyG-mediated cytotoxicity and apoptosis. Importantly, its therapeutic potential is also observed once the inclusions are already formed. We also show that CMBL4c-driven FMRpolyG loss is accompanied by partial FMRP reduction. As complete loss of FMRP induces FXS in children, future experiments should aim at evaluation of CMBL4c therapeutic intervention in differentiated tissues, in which FMRpolyG translation inhibition might outweigh adverse effects related to FMRP depletion.
Subarachnoid Hemorrhage as a Consequence of Pleomorphic Xanthoastrocytoma: A Case Report
Authors: Stone Lauren E , Goodwill Vanessa , Wali Arvin R , Hirshman Brian , Santiago-Dieppa David R , Khalessi Alexander 
Published: July 2021

Abstract

BACKGROUND AND IMPORTANCE
Pleomorphic xanthoastrocytoma (PXA) is a rare World Health Organization (WHO) grade II lesion considered to portend a good prognosis. However, the literature contains several references of serious intracranial hemorrhages associated with PXAs, although the etiology is poorly understood.

CLINICAL PRESENTATION
We present the case of a young woman with a Hunt and Hess V, Fisher 4 subarachnoid hemorrhage associated with a right cavernous sinus PXA. The case provides rare baseline angiographic imaging prior to a presenting hemorrhagic event and reveals progressive loss of structural vascular integrity at proximal large vessels.

CONCLUSION
This case provides insight into the natural history of this entity, tropism for catastrophic vascular injury, and informs surgical management with an emphasis on preoperative vascular imaging and preparation for proximal vascular control with cervical exposure.
Cohabitation With a Known Coronavirus Disease 2019 Case Is Associated With Greater Antibody Concentration and Symptom Severity in a Community-Based Sample of Seropositive Adults
Authors: Schrock Joshua M , Ryan Daniel T , Saber Rana , Benbow Nanette , Vaught Lauren A , Reiser Nina , Velez Matthew P , Hsieh Ryan , Newcomb Michael , Demonbreun Alexis R , Mustanski Brian , McNally Elizabeth M , D’Aquila Richard , McDade Thomas W 
Published: July 2021

AbstractIn a community-based sample of seropositive adults (n = 1101), we found that seropositive individuals who lived with a known coronavirus disease 2019 (COVID-19) case exhibited higher blood anti–severe acute respiratory syndrome coronavirus 2 spike receptor-binding domain immunoglobulin G concentrations and greater symptom severity compared to seropositive individuals who did not live with a known COVID-19 case.
Real-world Effect of Monoclonal Antibody Treatment in COVID-19 Patients in a Diverse Population in the United States
Authors: Rainwater-Lovett Kaitlin , Redd John T , Stewart Miles A , Calles Natalia Elías , Cluff Tyler , Fang Mike , Panaggio Mark J , Lambrou Anastasia S , Thornhill Jonathan K , Bradburne Christopher , Imbriale Samuel , Freeman Jeffrey D , Anderson Michael , Kadlec Robert P 
Published: July 2021

AbstractBackgroundMonoclonal antibodies (mAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are a promising treatment for limiting the progression of coronavirus disease 2019 (COVID-19) and decreasing strain on hospitals. Their use, however, remains limited, particularly in disadvantaged populations.MethodsElectronic health records were reviewed from SARS-CoV-2 patients at a single medical center in the United States that initiated mAb infusions in January 2021 with the support of the US Department of Health and Human Services’ National Disaster Medical System. Patients who received mAbs were compared with untreated patients from the time period before mAb availability who met eligibility criteria for mAb treatment. We used logistic regression to measure the effect of mAb treatment on the risk of hospitalization or emergency department (ED) visit within 30 days of laboratory-confirmed COVID-19.ResultsOf 598 COVID-19 patients, 270 (45%) received bamlanivimab and 328 (55%) were untreated. Two hundred thirty-one patients (39%) were Hispanic. Among treated patients, 5/270 (1.9%) presented to the ED or required hospitalization within 30 days of a positive SARS-CoV-2 test, compared with 39/328 (12%) untreated patients (P &lt; .001). After adjusting for age, gender, and comorbidities, the risk of ED visit or hospitalization was 82% lower in mAb-treated patients compared with untreated patients (95% CI, 56%–94%).ConclusionsIn this diverse, real-world COVID-19 patient population, mAb treatment significantly decreased the risk of subsequent ED visit or hospitalization. Broader treatment with mAbs, including in disadvantaged patient populations, can decrease the burden on hospitals and should be facilitated in all populations in the United States to ensure health equity.
Frequency-Specific Alterations in Brain Function in Patients with Primary Dysmenorrhea
Authors: Yu Siyi , Xu Jing , Shen Zhifu , Wang Yanan , Wei Wei , Guo Xiaoli , Tian Jin , Liu Liying , Yang Ya , Zeng Fang , Liang Fanrong , Yang Jie 
Published: July 2021

AbstractObjectiveRecent neuroimaging studies have found that brain function is abnormal in primary dysmenorrhea (PDM). The present study aimed to explore frequency-specific brain alterations and their occurrence in the PDM.MethodsForty-seven patients with PDM and 36 matched healthy controls were enrolled in the study and underwent resting-state functional magnetic resonance imaging. The alterations in brain function in patients with PDM were assessed with different frequency filter bands (Slow5, Slow4, Slow3, and full low frequency) and a functional connectivity density (FCD) approach. The clinical significance of the altered FCD was then explored. Additionally, mediation analysis was used to detect the altered FCD-mediated clinical relationships in PDM.ResultsFrequency-specific FCD alterations have been observed in patients with PDM, especially in the central executive, default mode, and sensorimotor networks and in the hippocampus. The altered full low-frequency FCD in the hippocampus was associated with the duration of disease and pain severity scores. The altered Slow5 FCD in the second somatosensory area (S2) was associated with the severity of pain in PDM. Furthermore, the FCD in S2 mediated the duration associated with pain symptoms in PDM.ConclusionThe present study identified frequency-specific FCD alterations in PDM and suggested that the S2 area is a potential treatment target for PDM.
The 5-Year Course of Neck Pain Among Natural Disaster Survivors: The Association of Prior Neck Pain with New Episodes of Neck Pain
Authors: Yabe Yutaka , Hagiwara Yoshihiro , Sekiguchi Takuya , Sugawara Yumi , Tsuchiya Masahiro , Yoshida Shinichirou , Onoki Takahiro , Takahashi Tadahisa , Iwatsu Jun , Tsuji Ichiro 
Published: July 2021

Abstract

Objective
Neck pain is a common health problem among both the general population and natural disaster survivors. However, the long-term course of neck pain has rarely been reported. The aim of this study was to elucidate the 5-year course of neck pain among survivors of the Great East Japan Earthquake (GEJE) by assessing the association of neck pain 2 and 4 years after the disaster with that at 7 years.

Study design
Longitudinal study.

Methods
A panel study was conducted on GEJE survivors (n = 1,821) through the administration of a self-reported questionnaire at 2 (first time point), 4 (second time point), and 7 years (third time point) after the disaster. Multivariate logistic regression analyses were performed to assess the association between prior neck pain and subsequent neck pain.

Results
The rates of neck pain at the first, second, and third time points were 20.7%, 21.1%, and 20.1%, respectively. Neck pain at the first time point was significantly associated with neck pain at the third time point (adjusted odds ratio [95% confidence interval]: 5.96 [4.53–7.83]). Furthermore, neck pain at the first and second time points was significantly associated with neck pain at the third time point (adjusted odds ratio [95% confidence interval]: 5.71 [4.19–7.78] for neck pain at either time point; 15.94 [10.99–23.12] for neck pain at both time points; P for trend &lt;0.001).

Conclusions
Prior neck pain was significantly associated with neck pain 5 years later, and the effect was stronger with an increase of prior neck pain episodes. Clinicians should base their selection of treatment method on an individual’s history of neck pain.
Single Adrenal Metastasis From Prostate Cancer Detected by 68Ga-PSMA PET/CT and Confirmed by Biopsy
Authors: Ribeiro André Marcondes Braga , Lima Eduardo Nóbrega Pereira , Garcia Daniel , Bezerra Stephania Martins 
Published: July 2021

Abstract
This image demonstrates an unusual presentation of an adrenal metastasis from prostate cancer detected by 68Ga–prostate-specific membrane antigen PET/CT and confirmed by biopsy. A 68-year-old man with prostate cancer persisted with elevated levels of prostate-specific antigen after radical prostatectomy. Imaging identified a single abnormal uptake in the left adrenal gland. A biopsy was performed showing a metastatic prostatic adenocarcinoma. The patient received systemic treatment, and his prostate-specific antigen level decreased significantly. Our objective is to illustrate an unusual and single site of prostate cancer metastasis, in which precise histological diagnosis was essential for correct clinical management of the patient.
A Rare Collecting Duct Carcinoma With Widespread Metastasis Visualized by 18F-FDG PET/CT
Authors: Li Dandan , Fu Chang , You Yang , Zhang Qianqian , Zhang Xiaoju 
Published: July 2021

Abstract
Collecting duct carcinoma is a rare and highly aggressive renal tumor with a poor prognosis. The presence of metastasis is common at collecting duct carcinoma diagnosis, but widespread metastases involving multiple soft tissues are extremely unusual. Here, we describe a 65-year-old man presenting with fever and lower leg pain as the first and main manifestations. After receiving anti-infective therapy for over 6 weeks without improvement, 18F-FDG PET/CT revealed a primary renal carcinoma with widespread metastases. A biopsy from the tubercle of fascicular spinal muscle indicated a diagnosis of collecting duct carcinoma.
DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts
Authors: Strand Siri H , Rivero-Gutiérrez Belén , Houlahan Kathleen E , Seoane Jose A , King Lorraine M , Risom Tyler , Simpson Lunden A , Vennam Sujay , Khan Aziz , Cisneros Luis , Hardman Timothy , Harmon Bryan , Couch Fergus , Gallagher Kristalyn , Kilgore Mark , Wei Shi , DeMichele Angela , King Tari , McAuliffe Priscilla F , Nangia Julie , Lee Joanna , Tseng Jennifer , Storniolo Anna Maria , Thompson Alastair M , Gupta Gaorav P , Burns Robyn , Veis Deborah J , DeSchryver Katherine , Zhu Chunfang , Matusiak Magdalena , Wang Jason , Zhu Shirley X , Tappenden Jen , Ding Daisy Yi , Zhang Dadong , Luo Jingqin , Jiang Shu , Varma Sushama , Anderson Lauren , Straub Cody , Srivastava Sucheta , Curtis Christina , Tibshirani Rob , Angelo Robert Michael , Hall Allison , Owzar Kouros , Polyak Kornelia , Maley Carlo , Marks Jeffrey R , Colditz Graham A , Hwang E Shelley , West Robert B 
Published: July 2021

SUMMARYDuctal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We have performed the first multiscale, integrated profiling of DCIS with clinical outcomes by analyzing 677 DCIS samples from 481 patients with 7.1 years median follow-up from the Translational Breast Cancer Research Consortium (TBCRC) 038 study and the Resource of Archival Breast Tissue (RAHBT) cohorts. We identified 812 genes associated with ipsilateral recurrence within 5 years from treatment and developed a classifier that was predictive of DCIS or IBC recurrence in both cohorts. Pathways associated with recurrence include proliferation, immune response, and metabolism. Distinct stromal expression patterns and immune cell compositions were identified. Our multiscale approach employed in situ methods to generate a spatially resolved atlas of breast precancers, where complementary modalities can be directly compared and correlated with conventional pathology findings, disease states, and clinical outcome.HIGHLIGHTS⍰ Development of a new classifier for DCIS recurrence or progression⍰ Outcome associated pathways identified across multiple data types and compartments⍰ Four stroma-specific signatures identified⍰ CNAs characterize DCIS subgroups associated with high risk invasive cancers
Auto tuning SIR model parameters using genetic algorithm
Authors: Kristen L. , Liu Fei 
Published: July 2021

AbstractEarlier studies [1] comparing Covid-19 simulations using extended SIR model [2] with observed new cases in New Jersey and United States showed good agreement between simulated results and observational data. The parameters of the SIR model controlling the behavior of the model have to be manually adjusted until the modelled results and observations reach good agreement. The parameter tuning process is tedious and time consuming. In this work, we have developed an approach using genetic algorithm [3] to automatically select the most optimal set of parameters to minimize the residual between simulated result and observational data. The parameter tuning process applying SIR model can now be automated without tedious and time consuming manual intervention.
Off-season RSV epidemics in Australia after easing of COVID-19 restrictions
Authors: Eden John-Sebastian , Sikazwe Chisha , Xie Ruopeng , Deng Yi-Mo , Sullivan Sheena G. , Michie Alice , Levy Avram , Cutmore Elena , Blyth Christopher C , Britton Philip N , Crawford Nigel , Dong Xiaomin , Dwyer Dominic E. , Edwards Kimberly M. , Horsburgh Bethany A. , Foley David , Kennedy Karina , Minney-Smith Cara , Speers David , Tulloch Rachel L. , Holmes Edward C. , Dhanasekaran Vijaykrishna , Smith David W. , Kok Jen , Barr Ian G. ,   Australian RSV study group
Published: July 2021

AbstractHuman respiratory syncytial virus (RSV) is an important cause of acute respiratory infection (ARI) with the most severe disease in the young and elderly1,2. Non-pharmaceutical interventions (NPIs) and travel restrictions for controlling COVID-19 have impacted the circulation of most respiratory viruses including RSV globally, particularly in Australia, where during 2020 the normal winter epidemics were notably absent3–6. However, in late 2020, unprecedented widespread RSV outbreaks occurred, beginning in spring, and extending into summer across two widely separated states of Australia, Western Australia (WA) and New South Wales (NSW) including the Australian Capital Territory (ACT). Genome sequencing revealed a significant reduction in RSV genetic diversity following COVID-19 emergence except for two genetically distinct RSV-A clades. These clades circulated cryptically, likely localized for several months prior to an epidemic surge in cases upon relaxation of COVID-19 control measures. The NSW/ACT clade subsequently spread to the neighbouring state of Victoria (VIC) and caused extensive outbreaks and hospitalisations in early 2021. These findings highlight the need for continued surveillance and sequencing of RSV and other respiratory viruses during and after the COVID-19 pandemic as mitigation measures introduced may result in unusual seasonality, along with larger or more severe outbreaks in the future.
Profiling lockdown adherence and poor coping responses towards the COVID-19 crisis in an international cross-sectional survey
Authors: Van Belle Sylvia , Dahlén Amelia , Schiöth Helgi B. , Brooks Samantha J. 
Published: July 2021

AbstractThis study uses international respondents to a COVID-lockdown related questionnaire (n = 1,688) to assess the determinants of adherence and poor coping in response to lockdown measures. A regression analysis was used to compare the relative importance of clusters derived from a K-means cluster analysis as well as various demographics (age, gender, level of education, political affiliation, a factor reflecting social security and a factor reflecting the lockdown harshness). Three distinct clusters (“General Population”, “Extreme Responders” and “Sufferers) were identified, corresponding well to a previous study. Clusters appeared to be the best overall predictors of coping and adherence although gender, political affiliation and lockdown harshness were also important predictors. The large proportion of variance that remains unexplained, combined with the relatively weak effects of traditional demographics, suggest that less concrete variables such as personality traits, health and environmental factors may be better predictors of adherence and coping during a pandemic.
Preconditioning by voluntary wheel running attenuates later neuropathic pain via Nrf2 antioxidant signaling in rats
Authors: Green-Fulgham Suzanne M. , Harland Michael E. , Ball Jayson B. , D’Angelo Heather , Dreher Renee A. , Li Jiahe , Lacagnina Michael J. , Lorca Sabina A. , Kwilasz Andrew J. , Maier Steven F. , Watkins Linda R. , Grace Peter M. 
Published: July 2021

AbstractAnimal and human studies have shown that exercise prior to nerve injury prevents later chronic pain, but the mechanisms of such preconditioning remain elusive. Given that exercise acutely increases formation of free radicals, triggering antioxidant compensation, we hypothesized that voluntary running preconditioning would attenuate neuropathic pain by supporting redox homeostasis after sciatic nerve injury in male and female rats. We show that 6 weeks of voluntary wheel running suppresses neuropathic pain development induced by chronic constriction injury (CCI) across both sexes. This protection was associated with reduced nitrotyrosine immunoreactivity—a marker for peroxynitrite—at the sciatic nerve injury site. Our data suggest that prior voluntary wheel running does not reduce production of peroxynitrite precursors, as expression levels of inducible nitric oxide synthase and NADPH oxidase 2 were unchanged. Instead, voluntary wheel running increased superoxide scavenging by elevating expression of superoxide dismutases 1 and 2. Prevention of neuropathic pain was further associated with activation of the master transcriptional regulator of the antioxidant response, nuclear factor E2-related factor 2 (Nrf2). Six weeks of prior voluntary wheel running increased Nrf2 nuclear translocation at the sciatic nerve injury site; in contrast, 3 weeks of prior wheel running, which failed to prevent neuropathic pain, had no effect on Nrf2 nuclear translocation. The protective effects of prior voluntary wheel running were mediated by Nrf2, as suppression was abolished across both sexes when Nrf2 activation was blocked during the running phase. This study provides insight into the mechanisms by which physical activity may prevent neuropathic pain.
Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
Authors: Narayan Satya , Raza Asif , Mahmud Iqbal , Koo Nayeong , Garrett Timothy J. , Law Mary E. , Law Brian K. , Sharma Arun K. 
Published: July 2021

SUMMARYThe treatment of colorectal cancer (CRC) with FOLFOX shows some efficacy, but these tumors quickly develop resistance to this treatment. We have observed an increased phosphorylation of AKT1/mTOR/4EBP1 and levels of p21 in FOLFOX-resistant CRC cells. We have identified a small molecule, NSC49L, that stimulates protein phosphatase 2A (PP2A) activity, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation. We have provided evidence that NSC49L- and TRAIL-mediated sensitization is synergistically induced in p21-knockdown CRC cells, which is reversed in p21-overexpressing cells. p21 binds with procaspase 3 and prevents activation of caspase 3. We have shown that TRAIL induces apoptosis through the activation of caspase 3 by NSC49L-mediated downregulation of p21 translation, and thereby cleavage of procaspase 3 into caspase 3. NSC49L does not affect global protein synthesis. These studies provide a mechanistic understanding of NSC49L as a PP2A agonist, and how its combination with TRAIL sensitizes FOLFOX-resistant CRC cells.Graphical Abstract