bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the COVID-19 pandemic on the activity of the Radiological Emergency Department: the experience of the Maggiore della Carità Hospital in Novara
Authors: Garlisi C. , Licandro D. , Siani A. , Rodolfi S. , Pansini S. , Garcia Navarro L. I. , Carriero A. , Avanzi G. C. , Castello L. M. 
Published: April 2021

Abstract

Purpose
During the first peak of the COVID-19 pandemic, the activity of Emergency Departments worldwide changed dramatically, focusing on diagnosis and care of the Sars-Cov-2 associated disease. These major changes also involved the activity of the Emergency Radiology Department (ERD). This study aimed to analyse the impact of the COVID-19 pandemic on imaging studies, both in terms of the amount, frequency and subspecialty of different imaging modalities requested to the ERD of the Maggiore della Carità Hospital in Novara (Italy).

Methods
To this end, our observational study took into account the imaging studies requested by the emergency department during three-time spans. These were defined as phase 0 (pre-pandemic), phase 1 (pandemic peak with complete lockdown) and phase 2 (post-pandemic peak with partial lifting of restrictive measures), as derived from Italian urgent decrees by the President of the Council of Ministers (DPCM) which established the duration and entity of the lockdown measures throughout the pandemic. The dataset was processed and then compared with Pearson’s chi-squared test.

Results
During the pandemic peak, our data showed a significant drop in the total number of studies requested and a significant rise in computed tomography (CT) studies. In particular, a statistically significant increase in chest CT studies was found, probably due to the high sensitivity of this imaging method in identifying pulmonary involvement during respiratory tract infection of possible viral etiology (SARS-Cov-2). Moreover, we observed a statistically significant decrease of X-ray (XR) and ultrasound (US) studies during phase 1 compared to phase 0 and phase 2 probably due to a reduction in the numbers of ER visits for minor traumas given the mobility restrictions and people hesitancy in visiting the ER due to fear of contagion.

Conclusions
We can conclude that the activity of the ERD was heavily impacted by the SARS-Cov-2 pandemic. Further studies will be needed to estimate the impact of the pandemic on public health in terms of excess mortality related to delayed diagnosis and care of non-COVID diseases.
An economic analysis of a wearable patient sensor for preventing hospital-acquired pressure injuries among the acutely ill patients
Authors: Nherera Leo , Larson Barrett , Cooley Annemari , Reinhard Patrick 
Published: April 2021

AbstractMore than 2.5 million people in the United States develop pressure injuries annually, which are one of the most common complications occurring in hospitals. Despite being common, hospital-acquired pressure injuries (HAPIs) are largely considered preventable by regular patient turning. Although current methodologies to prompt on-time repositioning have limited efficacy, a wearable patient sensor has been shown to optimize turning practices and improve clinical outcomes. The purpose of this study was to assess the cost-effectiveness of patient-wearable sensor in the prevention of HAPIs in acutely ill patients when compared to standard practice alone. A decision analytic model was developed to simulate the expected costs and outcomes from the payer’s perspective using data from published literature, including a recently published randomized controlled trial. Both univariate and probabilistic sensitivity analysis were conducted. The patient-wearable sensor was found to be cost saving (dominant). It resulted in better clinical outcomes (77% reduction in HAPIs) compared to standard care and an expected cost savings of $6,621 per patient over a one-year period. Applying the model to a cohort of 1,000 patients, an estimated 203 HAPIs would be avoided with annualized cost reduction of $6,222,884 through all patient treatment settings. The probabilistic analysis returned similar results. In conclusion, the patient-wearable sensor was found to be cost-effective in the prevention of HAPIs and cost-saving to payers and hospitals. These results suggest that patient-wearable sensors should be considered as a cost-effective alternative to standard care in the prevention of HAPIs.
Technology-enhanced Learning for Promoting Technical and Social Competences in Hydrological Science
Authors: Licciardello Feliciana , Consoli Simona , Cirelli Giuseppe , Castillo Carlos , Fernández-Ahumada Elvira , Montejo-Gámez Jesús , Taguas Encarnación V. 
Published: April 2021

AbstractThis paper explains and analyses a virtual gamification experience developed by a teaching group from the University of Catania (Italy) and the University of Cordoba (Spain). A competition based on professional tasks about hydrological planning was implemented in two subjects on Hydrological Sciences. The teaching experience was designed to improve the acquisition of technical knowledge and skills needed for hydrological studies, promote the management of ICT and increase international cooperation between different universities; all aimed at making students more employable. The experience is transferable to different academic levels. Following the philosophy of soccer leagues, the students solved and presented the exercise by teams of two students. Through videoconference, the presentation and the explanation were done so the fans in each country supported their teams. The students found it a very challenging experience but at the same time, some of them were aware of their needs of improving technical knowledge, particularly Geographical Information Systems, and English language skills. Updating of tools and the schedule within the different academic calendar were their main organization handicaps. The main outcome of the presented experience is that social energy and enthusiasm associated to popular activities such as soccer led to improve the interest and the motivation of the students in challenging technical contents as well as teamwork and language transversal competences.
Cyclophosphamide treatment evoked side effect on skeletal muscle actin, monitored by DSC
Authors: Farkas Péter , Szatmári Dávid , Könczöl Franciska , Lőrinczy Dénes 
Published: April 2021

AbstractSeveral kind of drugs—used in cancer treatments—such as cyclophosphamide (CP) can also trigger a disease classified as toxic polyneuropathy. Polyneuropathy is a simultaneous malfunction of several peripheral nerves, typical side effect of a cancer therapy. In our previous study, we used CP treated in vitro animal model (Guinea pig) with a comparable dosage and time handling of human protocol to show evidences of this drug-induced effects. We could show a dose-dependent difference between in Tm and ΔHcal of untreated and treated samples assigned to their intact muscle and nerve, blood plasma and red blood cells. In our current study we analyze this side effect on skeletal muscle actin (prepared from m. psoas of rabbit) by DSC (differential scanning calorimetry), to follow the possible consequence of drug treatment on the “activator” of muscle contraction. We have demonstrated that run of DSC curves, Tms together with the ΔHcal exhibit clear CP effect. In case of Ca2+ G actin it is manifested in a well separated second high denaturing temperature as a consequence of CP binding into the cleft. This way the nucleotide binding cleft with subdomains 1 and 3 becomes less flexible, indicating clear sensitivity to CP treatment. In F-actin samples, the main peak represents the thermal denaturation of subdomains 1 and 3, and the increased calorimetric enthalpy administrating Ca2+ as well as CP refers to a more rigid structure. These alterations can be the molecular background in the malfunction of muscle in case of polyneuropathy after CP treatment.
PACAP and PAC1 Receptor Expression in Human Insulinomas
Authors: Ferencz Sandor , Toth Denes , Kaszas Balint , Bardosi Sebastian , Vicena Viktoria , Karadi Oszkar , Reglodi Dora , Kelemen Dezso 
Published: April 2021

AbstractPituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with widespread occurrence and diverse functions. PACAP binds to specific PAC1 and non-specific VPAC1/2 receptors. PACAP is considered as a growth factor, as it plays important roles during development and participates in reparative processes. Highest concentrations are found in the nervous system and endocrine glands, where several functions are known, including actions in tissue growth, differentiation and tumour development. Therefore, we have investigated expression of PACAP and its receptors in different tumours, including those of endocrine glands. We showed earlier that PACAP and PAC1 receptor staining intensity decreased in pancreatic ductal adenocarcinoma. In the present study we aimed to investigate alterations of PACAP and PAC1 receptor in human insulinoma and compared the immunostaining pattern with samples from chronic pancreatitis patients. We collected perioperative and histological data of patients who underwent operation because of insulinoma or chronic pancreatitis over a five-year-long period. Histology showed chronic pancreatitis with severe scar formation in pancreatitis patients, while tumour samples evidenced Grade 1 or 2 insulinoma. PACAP and PAC1 receptor expression was studied using immunohistochemistry. Staining intensity was very strong in the Langerhans islets of normal tissue and discernible staining was also observed in the exocrine pancreas. Immunostaining intensity for both PACAP and PAC1 receptor was markedly weaker in insulinoma samples, and disappeared from chronic pancreatitis samples except for intact islets. These findings show that PAC1 receptor/PACAP signalling is altered in insulinoma and this suggests a possible involvement of this system in tumour growth or differentiation.
Is Facebook an effective tool to access foreign markets? Evidence from international export performance of fashion firms
Authors: Mazzucchelli Alice , Chierici Roberto , Di Gregorio Angelo , Chiacchierini Claudio 
Published: April 2021

AbstractSocial networks are a driving force of digital transformation and offer firms the opportunity to market products and services to both international consumers and providers, establish durable relationships with them, and improve their own competitiveness. The study analyzes the role played by the use of Facebook for online advertising, building interaction and brand communities, implementing social CRM activities, and conducting market research, as well as a sales channel alternative to physical presence, in firms’ international export performance, both in terms of managers’ perceptions and Facebook buy button conversion rate. A survey-based empirical analysis of 105 fashion firms operating worldwide was conducted. The results of multiple regression analyses show that building conversations and brand communities positively affects international export performance, while advertising via Facebook yields mixed results. By comparing firms that have a physical presence with those that do not, the former turned out to benefit from especially in-store advertising and promotions to enhance their Facebook buy button conversion rate; while the latter can improve their performance mainly by adopting outdoor and transit advertising and digital marketing. The research contributes to the existing body of knowledge on social media marketing and international business and, by adopting a firm-level perspective, provides interesting insights for practitioners since it allows to understand how to develop an effective Facebook strategy to succeed in foreign markets.
Three doors anomaly, “should I stay, or should I go”: an artefactual field experiment
Authors: Morone Andrea , Caferra Rocco , Casamassima Alessia , Cascavilla Alessandro , Tiranzoni Paola 
Published: April 2021

AbstractThis work aims to identify and quantify the biases behind the anomalous behavior of people when they deal with the Three Doors dilemma, which is a really simple but counterintuitive game. Carrying out an artefactual field experiment and proposing eight different treatments to isolate the anomalies, we provide new interesting experimental evidence on the reasons why subjects fail to take the optimal decision. According to the experimental results, we are able to quantify the size and the impact of three main biases that explain the anomalous behavior of participants: Bayesian updating, illusion of control and status quo bias.
Time-Dependent Electrical Contact Resistance at the Nanoscale
Authors: Vazirisereshk Mohammad R. , Sumaiya Saima A. , Chen Rimei , Baykara Mehmet Z. , Martini Ashlie 
Published: April 2021

AbstractConductive-atomic force microscopy (C-AFM) and molecular dynamics (MD) simulations are used to investigate time-dependent electrical contact resistance (ECR) at the nanoscale. ECR is shown to decrease over time as measured using C-AFM and estimated using two approaches from MD simulations, although the experiments and simulations explore different time scales. The simulations show that time dependence of ECR is attributable to an increase in real contact area due to atoms diffusing into the contact. This diffusion-based aging is found to be a thermally activated process that depends on the local contact pressure. The results demonstrate that contact aging, previously identified as an important mechanism for friction, can significantly affect electrical conduction at the nanoscale.Graphical Abstract
A Method for Tribological Measurements of Coated Abrasives using a Rheometer
Authors: Gammelgård Andreas , Tuuf Jessica , Strand Anders , Sundell Mats , Björklund-Sänkiaho Margareta 
Published: April 2021

AbstractCoated abrasives (sandpaper) are imperative in various industrial areas, including the automotive and the metal industry. An exact outcome is often highly appreciated in abrasion processes, which means that the wear process must be precisely controlled. In this paper, a new method for analyzing the grinding process of coated abrasives is proposed. In order to study the grinding properties of sandpaper, a tribology cell was connected to a rheometer. The experiments consisted of unlubricated (dry) steel balls-on-disc experiments on coated abrasive with aluminum oxide grains. The friction and wear data showed that the rheometer equipped with a tribology cell can be used to measure different tribological parameters, such as the friction coefficient and the Gap. The wear process was investigated over a range of abrasive grain sizes (9–40 µm) and a variety of different loads (1–10 N). Results from these experiments showed that the abrasive wear increased with increasing particle size and normal load. Hence, it is proposed that this method is a reliable approach for investigating the wear process of coated abrasives.
Human–nature connectedness and other relational values are negatively affected by landscape simplification: insights from Lower Saxony, Germany
Authors: Riechers Maraja , Martín-López Berta , Fischer Joern 
Published: April 2021

AbstractLandscape simplification is a worldwide phenomenon that impacts biodiversity in agricultural landscapes. Humans benefit greatly from nature’s contributions to people in both material and immaterial ways, yet landscape simplification can undermine these contributions. Landscape simplification can have negative consequences, for example, for human–nature connectedness and other relational values. Major and rapid land-use change, together with a declining appreciation of nature by individuals and societies, in turn, could cause a downward spiral of disconnections. Our empirical research combined a comprehensive assessment of five dimensions of human–nature connectedness with the lens of relational values to assess how these are influenced by landscape simplification. Focusing on two rural landscapes with differing agricultural development in Lower Saxony (Germany), we conducted 34 problem-centred interviews. We found that landscape simplification, especially if rapid, negatively influenced human–nature connectedness and particular relational values such as social relations, social cohesion or cultural identity. We postulate that human–nature connectedness might have a balancing influence on preserving relational values, buffering negative impacts of landscape simplification. Losing connections to nature could potentially foster conflicts among actors with different values. We conclude that combining the notions of human–nature connectedness and relational values can generate valuable insights and may help to uncover new ways to foster sustainability.
Long-term Emergency Department Visits and Readmissions After Laparoscopic Roux-en-Y Gastric Bypass: a Systematic Review
Authors: van Olst N. , van Rijswijk A. S. , Mikdad S. , Schoonmade L. J. , van de Laar A. W. , Acherman Y. I. Z. , Bruin S. C. , van der Peet D. L. , de Brauw L. M. 
Published: April 2021

Abstract
Purpose
There is considerable evidence on short-term outcomes after laparoscopic Roux-en-Y gastric bypass (LRYGB), but data on long-term outcome is scarce, especially on postoperative emergency department (ED) visits and readmissions. We aim to systematically review evidence on the incidence, indications, and risk factors of ED visits and readmissions beyond 30 days after LRYGB.

Materials and Methods
A systematic search in PubMed, Scopus, Embase.com, Cochrane Library, and PsycINFO was performed. All studies reporting ED visits and readmissions > 30 days after LRYGB, with ≥ 50 patients, were included. PRISMA statement was used and the Newcastle-Ottawa Scale for quality assessment.

Results
Twenty articles were included. Six studies reported on ED visits (n = 2818) and 19 on readmissions (n = 276,543). The rate of patients with an ED visit within 90 days after surgery ranged from 3.9 to 32.6%. ED visits at 1, 2, and 3 years occurred in 25.6%, 30.0%, and 31.1% of patients. Readmissions within 90 days and at 1-year follow-up ranged from 4.1 to 20.5% and 4.75 to 16.6%, respectively. Readmission was 29% at 2 years and 23.9% at 4.2 years of follow-up. The most common reason for ED visits and readmissions was abdominal pain.

Conclusion
Emergency department visits and readmissions have been reported in up to almost one in three patients on the long-term after LRYGB. Both are mainly indicated for abdominal pain. The report on indications and risk factors is very concise. A better understanding of ED visits and readmissions after LRYGB is warranted to improve long-term care, in particular for patients with abdominal pains.
Gaining flexibility in dealing with arithmetic situations: a qualitative analysis of second graders’ development during an intervention
Authors: Gabler Laura , Ufer Stefan 
Published: April 2021

AbstractThe influence of language and situation structure on the difficulty of word problems has been investigated intensively in the field of mathematics education. However, instructional approaches to overcoming students’ difficulties are still not widely available. This paper describes an intervention to develop second graders’ skills in handling additive word problems flexibly. During ten small-group sessions of 40 min, two strategies to restructure the situation described in a word problem were introduced: (1) changing the direction of mathematical relations and (2) changing semantic structures. The introduction of these strategies was supported using macro-scaffolding. The development of students’ flexibility in dealing with arithmetic situations during the intervention was analyzed in a longitudinal case study focusing on four students, who were preselected from a larger sample based on their language skills. We examined audio data and student work by applying qualitative content analysis. Students’ development in handling word problems flexibly was compared with the intended learning trajectory in the intervention. The results provide insights into potential key processes when gaining flexibility, and yield information on the necessary adaptations of the learning trajectory.
Chemical modification of betel nut husk prepared by sodium hydroxide for methylene blue adsorption
Authors: Novera Tamanna Mamun , Tabassum Mumtahina , Bardhan Mondira , Islam Md. Azharul , Islam Md. Atikul 
Published: April 2021

AbstractIn recent years, different biomaterials have garnered more research attention due to their usefulness as adsorbents. The present study focuses on a chemical treatment process to improve the adsorption capacity of betel nut husk fibers for a textile effluent (methylene blue). The fibers of chemically modified material were assessed using Fourier transform infrared (FTIR) spectrometer and Brunauer–Emmett–Teller (BET) analyzer to determine the existing surface functional groups and surface area, respectively. Parameters including contact time, dye concentration, temperature, effects of pH and desorption efficiency were also evaluated to identify optimum adsorption performance. Adsorption followed the Freundlich isotherm model and pseudo-first-order kinetics, indicating physisorption was responsible for adsorption and its occurrence on multilayers. Adsorption capacity was 149.921 mg/g, 149.874 mg/g and 145.462 mg/g at 30, 40 and 50, respectively, and was best at 30 °C. ΔH° was found to be − 1.494 which suggests adsorption is exothermic in nature and thus satisfying the findings that the physical process of adsorption took place in this study.
The #orthorexia community on Instagram
Authors: Valente Martina , Renckens Sophie , Bunders-Aelen Joske , Syurina Elena V. 
Published: April 2021

Abstract
Purpose
This mixed-methods study delved into the relationship between orthorexia nervosa (ON) and Instagram.

Methods
Two quantitative data sources were used: content analysis of pictures using #orthorexia (n = 3027), and an online questionnaire investigating the experience of ON and the use of Instagram of people sharing ON-related content on Instagram (n = 185). Following, interviews (n = 9) were conducted with people posting ON-related content on Instagram and self-identifying as having (had) ON.

Results
People who share ON-related content on Instagram were found to be primarily young women (questionnaire = 95.2% females, mean age 26.2 years; interviews = 100% females, mean age 28.4 years), who were found to be heavy social media users and favor Instagram over other platforms. Questionnaire respondents agreed in defining ON as an obsession with a diet considered healthy, with bio-psycho-social negative consequences, though those who self-identified as having (had) ON were more likely to point out the negative impairments of ON. Interviewees deemed Instagram partially responsible for the development of ON. Instead, they agreed that Instagram encourages problem realization. Content analysis showed that ON is encoded in pictures of ‘food’, ‘people’, ‘text’ and ‘other.’ Interviewees revealed that they started posting to recover, share information, help others, and they felt inspired to post by other accounts. A sense of belonging to the #orthorexia community emerged, where people share values and ideals, and seek validation from others.

Conclusion
Conversations around #orthorexia on Instagram generate supportive communities aiding recovery. Individuals use Instagram for helping others and themselves recovering from ON. Understanding how people help each other, manage their health, cope with symptoms, and undertake recovery can inform the implementation of therapeutic interventions for ON.

Level of evidence
Level III, evidence obtained from well-designed cohort or case–control analytic studies.