bluuebunny/crossref_metadata_2025_split huggingface dataset:
Borderline Personality Disorder in Young People: Associations with Support and Negative Interactions in Relationships with Mothers and a Best Friend
Authors: Hessels Christel , Berg Tessa van den , Lucassen Sofie A. , Laceulle Odilia M. , Aken Marcel A.G. van 
Published: September 2021

Abstract
Background:Impaired interpersonal functioning has been highlighted as a core feature of borderline personality disorder (BPD). Adolescence and young adulthood form important developmental stages within both the emergence of BPD and the development of interpersonal functioning, which takes place mostly in relationships with parents and friends. This study aimed to: (i) investigate relations between BPD symptoms and both supportive and negative interactions with mothers and best friends; (ii) investigate whether the relations were moderated by age; (iii) test the robustness of our findings by comparing the results based on self-reports with results from a subsample in which supportive and negative interactions with mothers were rated by the mother.Methods312 young people referred to mental healthcare completed self-report measures on BPD and supportive and negative interactions. Multiple regression analyses were conducted to examine the relations between BPD features and perceived supportive and negative interactions with mothers and best friend, and to investigate whether these relations were moderated by age. Robustness of our findings was studied in a subsample (n = 104) by using a multi-informant design in maternal report on supportive and negative interactions with mothers. ResultsMultiple regression analyses demonstrated that negative interactions with mothers as well as with a best friend were related to more BPD symptoms in young people. Supportive interactions were not related to BPD symptoms. Both BPD and quality of relations were not related to age. In a subsample in which supportive and negative interactions with mothers were rated by the mother, the maternal report showed slightly different results. In this model, both supportive and negative interactions with a best friend were positively related, whereas interactions with mothers were not related to BPD symptoms in young people.ConclusionsResults highlight the importance of relationships with mothers and a best friend during adolescence and young adulthood. Given that BPD often emerges during this developmental phase, future research is needed to clarify how quality of relationships could alter pathways toward BPD in young people.
Intrinsic Molecular Characteristics of the Immune Subtypes of Salivary Mucoepidermoid Carcinoma
Authors: Kang Hyundeok , Seo Mi-Kyoung , Park BeumJin , Koh Yoon Woo , Kim Dahee , Kim Sangwoo 
Published: September 2021

Abstract
Background: Characterising the tumor microenvironment (TME) and immune landscape of cancer has been a promising step towards discovering new therapeutic biomarkers and guiding precision medicine; however, its application in salivary mucoepidermoid carcinoma (MEC) has been sparse. Here, we conducted a comprehensive transcriptomic study to understand the properties of the TME and immune profiles of MEC.Methods: Molecular features in heterogeneous immunophenotypic subgroups of MEC and their intrinsic characteristics were determined by applying bioinformatic and immunoinformatic analyses on 20 matched primary MEC RNA-seq data.Results: In this study, distinct two immunophenotypic subgroups, hot and cold MECs, were uncovered with their distinct molecular features, and potential immune-oncologic therapeutic options for each subgroup were suggested. In search for immunophenotype defining molecular features, tumor mutational burden, CRTC1-MAML2 fusion status, and its fusion neoantigen were not discriminable factors. However, we demonstrate that a significant inverse correlation between lipid metabolism activity and immunogenic state, and lipid metabolic regulators, such as MLXIPL and FASN, which are associated suppression of immune activity, were under-expressed in the immune-hot subgroup, contributing significant role in high immunity of immune active subgroup.Conclusions: Our study has shown heterogeneous immunophenotypic MEC subgroups with their distinctive molecular characteristics and provided potential treatment options tailored to the immune context, which yields, for the first time, new insights into TME of MEC and may help the next step to studying this uncharted cancer.
Shenmai Injection Alleviates Cardiomyocyte Apoptosis Induced by Doxorubicin
Authors: Zhang Xiaonan , Li Yanyang , Zhang Wanqin , Jia Qiujin , Zhu Yaping , Zhang Junping , Lv Shichao , Liu Longtao 
Published: September 2021

Abstract
Background: Shenmai Injection (SMI) is a patented Chinese medicine extract, has been widely used to treat myocardial damage caused by doxorubicin (DOX), but its underlying mechanisms remain elusive. The study aimed to explore the protective effect of SMI on myocardial injury caused by DOX in vivo.Methods: The male Sprague-Dawley (SD) rats received DOX (2mg/kg) tail vein injection every week for 4 weeks, with or without SMI and miR-30a agomir treatment for 2 weeks. The protective effect of SMI on myocardial injury caused by DOX has been determined by measuring rat body mass and general heart morphology, myocardial pathological changes, and serum markers. The myocardial pathological changes were observed by Van Gieson (VG) staining, the serum marker levels of myocardial injury were detected by ELISA, the myocardial cell apoptosis was observed by TUNEL assay and transmission electron microscope, and the expression of target protein was detected by Western Blot.Results: SMI treatment significantly reduced rat HMI and LVMI, reduced the levels of serum CK, LDH, cTnT, NT-proBNP, and also reduced the levels of serum sST2 and GDF-15, and reduced the expression of rat myocardial type I and type III collagen, which was effective reduce the fibrosis of myocardial collagen knot tissue and interstitial. The study further found that SMI can increase the expression of Bcl-2 protein, reduce the expression of Bax, Caspase-9, and Caspase-3 protein, and reduce the apoptotic index of cardiomyocytes. Conclusion: The potential mechanism of SMI on cardiomyocytes from apoptosis induced by the DOX may be attributed to the regulation of miR-30a/beclin 1.
B-Cell-Depletion Reverses Dysbiosis of the Microbiome in Multiple Sclerosis Patients
Authors: Troci Alba , Zimmermann Olga , Esser Daniela , Krampitz Paula , May Sandra , Franke Andre , Berg Daniela , Leypoldt Frank , Stürner Klarissa Hanja , Bang Corinna 
Published: September 2021

Abstract
Objective: To elucidate cross-sectional patterns and longitudinal changes of oral and stool microbiota in multiple sclerosis (MS) patients and the effect of B-cell depletion.Methods: We conducted an observational, longitudinal clinical cohort study analysing four timepoints over 12 months in 36 MS patients, of whom 22 initiated B-cell depleting therapy with ocrelizumab and a healthy control group. For microbiota analysis of the oral cavity and the gut, provided stool and oral swab samples underwent 16S rDNA sequencing and subsequent bioinformatic analyses. Results: Oral microbiota-patterns exhibited a reduced alpha-diversity and unique differential microbiota changes compared to stool such as increased levels of Proteobacteria and decreased abundance of Actinobacteria. Following B-cell depletion, we observed increased alpha-diversity in the gut and the oral cavity as well as a long-term sustained reduction of pro-inflammatory Gram-negative bacteria (e.g., Escherichia/Shigella).Conclusion: MS patients have altered stool and oral microbiota diversity patterns compared to healthy controls, which are most pronounced in patients with higher disease activity and disability. Therapeutic B-cell depletion is associated with persisting regression of these changes. Whether these microbial changes are unspecific side-effects of B-cell depletion or indirectly modulate MS disease activity and progression is currently unknown and necessitates further investigations.
A Simple Method To Valorize Silica Sludges Into Sustainable Coatings For Indoor Humidity Buffering
Authors: Kuok Chi-Hong , Dianbudiyanto Wahid , Liu Shou-Heng 
Published: September 2021

Abstract
In this study, the production of indoor humidity-buffering coatings (IHC-s) from recycling waste silica sludges by using a room-temperature sol-gel method which is a simple and energy-efficient route is reported. The properties of these IHC-s coatings are identified by scanning electron microscope, X-ray diffraction, X-ray fluorescence spectrometer, laser particle size analyzer, N2 adsorption-desorption isotherms and toxicity characteristic leaching procedure (TCLP). The moisture adsorption-desorption tests show that the IHC-s coatings have moisture buffering values of ca. 270-316 g m-2 and moisture contents of 24-27% in the range of 50-90% relative humidity (RH). Furthermore, the humidity buffering capacities, moisture adsorption-desorption rate and stability are significantly superior to commercially available coatings in the range of 50-75% RH. The enhancement may be due to the formation of porous structure in the coatings via the dispersed waste silica sludges and gypsum which transformed from bassanite by self-assembly process. Most importantly, the prepared IHC-s coatings show surpassing antimicrobial efficacy (> 99.99%) and no detectable leaching heavy metals based on TCLP tests, which provides an economic and environmental-friendly route for recovering and valorizing industrial wastes.
Associations Between Post-migration Stressors and Psychiatric Disorders in Adult Refugees in European High Income Countries. A Systematic Review
Authors: Nowak Anna Christina , Boettcher Victoria Sophie , Gehrlein Lea-Marie , Hornberg Claudia 
Published: September 2021

Abstract
Background: Refugees and asylum seekers have a high prevalence of psychiatric disorders such as posttraumatic stress disorder (PTSD), anxiety and depression. Associations between the number of traumatic events and psychiatric disorders have been reported in literature, but knowledge on the influence of post-migration stressors on mental health outcomes in host countries remains scarce. Method: Four databases in the field of public and mental health were systematically searched. From a total of 2,456 studies found, 1,777 were included for title and abstract screening and 61 full texts were separately screened for eligibility by 2 authors. Out of these studies, 23 studies were included in this systematic review. A narrative synthesis was undertaken.Results: The overall findings showed that post-migration stressors have a significant impact on mental health outcomes. Especially uncertain legal status, missing social support and unemployment were shown to negatively influence mental health, but results vary among the different psychiatric disorders, i.e. post-traumatic stress disorder, depression and anxiety. Discussion: Post-migration stressors can contribute to the high prevalence rates of psychiatric disorders in refugees in European high-income countries. However, results must be interpreted with caution because of the heterogeneous study populations included and the variety of post-migration stressors. None of the studies considered the effect of mental disorders on the perceived severity of post-migration stressors.
Revisiting Statistics and Evidence-Based Medicine: On the Fallacy of the Effect Size Based on Correlation and Misconception of Contingency Tables
Authors: Roussakow Sergey 
Published: September 2021

Abstract
BACKGROUND: Evidence-based medicine (EBM) is in crisis, in part due to bad methods, which are understood as misuse of statistics that is considered correct in itself. The correctness of the basic statistics related to the effect size (ES) based on correlation (CBES) was questioned. METHODS: Monte Carlo simulation of two paired binary samples, mathematical analysis, conceptual analysis, bias analysis. RESULTS: Actual effect size and CBES are not related. CBES is a fallacy based on misunderstanding of correlation and ES and confusion with 2 × 2 tables that makes no distinction between gross crosstabs (GCTs) and contingency tables (CTs). This leads to misapplication of Pearson’s Phi, designed for CTs, to GCTs and confusion of the resulting gross Pearson Phi, or mean-square effect half-size, with the implied Pearson mean square contingency coefficient. Generalizing this binary fallacy to continuous data and the correlation in general (Pearson’s r) resulted in flawed equations directly expressing ES in terms of the correlation coefficient, which is impossible without including covariance, so these equations and the whole CBES concept are fundamentally wrong. misconception of contingency tables (MCT) is a series of related misconceptions due to confusion with 2 × 2 tables and misapplication of related statistics. Problems arising from these fallacies are discussed and the necessary changes to the corpus of statistics are proposed resolving the problem of correlation and ES in paired binary data. CONCLUSIONS: Two related common misconceptions in statistics have been exposed, CBES and MCT. The misconceptions are threatening because most of the findings from contingency tables, including meta-analyses, can be misleading. Since exposing these fallacies casts doubt on the reliability of the statistical foundations of EBM in general, we urgently need to revise them.
Mindfulness Meditation Apps: An Effective Tool to Improve Mental Health Among Graduate Students in STEM Programs
Authors: Grogan Kelly A. 
Published: September 2021

Abstract
This paper seeks to determine whether or not mindfulness meditation training via a simple meditation app can effectively improve well-being among graduate students enrolled in STEM programs. Graduate students were recruited from STEM programs at the University of Florida. Participants were randomly assigned into treatment and control groups. The control group simply proceeded as they normally would during an academic semester. The treatment group received free access to the Ten Percent Happier app and were asked to meditate once per day for eight weeks. Both groups completed pre-, mid-, and post-intervention surveys that included the Center for Epidemiological Depression Scale (CES-D) and the Generalized Anxiety Disorder 7-Item Scale (GAD-7). The treatment group averaged about 10 minutes of meditation per day, and the average participant meditated on about 82% of days within the intervention period. At the end of the 8-week intervention, the treatment group reported CES-D and GAD-7 scores that were about 35% and 41% lower than the control group and their physical symptom score was about 36% lower. Relative to their own starting scores, CES-D, GAD-7, and physical symptom scores decreased 35%, 50%, and 43%, respectively for the treatment group, while the control group experienced no change in scores.
Spectral Discrimination of Six Dominant Seaweed Species in the Intertidal Zone of GouQi Island
Authors: chen jianqu , li xunmeng , Wang Kai , Zhang Shouyu , Zhang Jian , gao weicheng 
Published: September 2021

Abstract
Probing the coverage and biomass of seaweed is the basis for achieving sustainable utilization of nearshore seaweed resources. Unlike traditional sample surveys, remote sensing technology can realize dynamic monitoring on a large scale and for a long time. In this paper, we measured the spectral data of six dominant seaweed species in different dry and wet conditions in the intertidal zone of Gouqi Island: Ulva pertusa, Sargassum thunbergii, Chondrus ocellatus, Chondria crassiaulis Harv., Grateloupia filicina C. Ag., and Hizikia fusifarme. The different seaweed species were identified and analyzed by a combination of ANOVA and support vector machine (SVM). Fourteen common spectral parameters were used as input variables, and the input parameters were filtered by ANOVA. The samples were divided into a training set (266 samples) and a test set (116 samples) at a 3:1 ratio for input into the SVM model. The results showed that when the input parameters were NDVI (Rg,Rr), RVI (Rg,Rr), Vre, Abe, Lbe, Lg, Lre, and Rr and the model parameters g=1.30 and c=2.85, the maximum discrimination rate of the six different wet and dry states of seaweed was 74.96%, and the highest accuracy was 93.94% when distinguishing different phyla of seaweed (g=6.85 and c=2.55). In addition, SVM is fused with XGBoost (eXtreme Gradient Boosting) by vote and further classified in combination with the selected parameters. The accuracy of the six seaweeds was 73.98% (vote mean score = 0.972). In this study, the spectral data of intertidal seaweed in different dry and wet states were classified for the first time to provide technical support for remote sensing monitoring of coastal zones and seaweed resource statistics.
Survey the Immuno-pharmacology Effect of Botulinum Toxin in Cell Signaling of Bronchial Smooth Muscle Cells of the Allergic Asthma
Authors: Cheng Chao , Nasab Entezar Mehrabi , athari seyyed shamsadin 
Published: September 2021

Abstract
BackgroundAsthma is the lung disease that influenced more than 350 million people in worldwide. ASM spasm leads to AHR and bronchial obstruction that are acute symptoms of asthma attack. BTX is bacteria toxin that acts as muscle relaxant and may have therapeutic effect on AHR and asthma. Therefore, the effect of BTX on the AHR and related gene expression was evaluated.MethodsAfter producing of asthma mice model, which were treated with BTX in two ways; IN and N (0.01, 0.1, 1 and 10 U/ml). AHR was measured on day 24, 26, 28, 30 and gene expression of TrkA, TrkB, M1-M5, α7nAChR, TNF-α and ERK2 were evaluated. At least, in lung histopathology, perivascular and peribronchial inflammation, mucus production and goblet cell hyperplasia were studied. ResultsOn day 24, treatment with BTX for all dosages had no significant effect on AHR but, on day 26 and 28, AHR was decreased and it was continued on day 30 for all treated groups. Treatment with BTX had no significant effect on the expressions of TrkA, TrkB, M1, M2, M3, M4, M5, α7nAChR, TNF-α and ERK2 genes, perivascular inflammation, peribronchial inflammation, hyperplasia of the goblet cell and production of mucus. Also, the mice have been received BTX 10 mg/ml, were died. ConclusionsBTX therapy controlled asthma attacks via decreasing of AHR and induction of relaxation in the ASMs. But, it has no significant effect on inflammation and mucus production. In using of BTX, attention to the safe dose and prevention of dangerous side effects are necessary.
Integrated Bioinformatics Analysis of Gene Expression Profiles for Potential Biomarker Identification Towards Early Therapeutic Intervention in Pancreatitis and Pancreatic Ductal Adenocarcinoma
Authors: Wagle Manoj M , Kedige Ananya Rao , Kabekkodu Shama P , Mallya Sandeep 
Published: September 2021

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a malignancy associated with rapid progression and an abysmal prognosis. It has been reported that chronic pancreatitis can increase the risk of developing PDAC by 16-fold. Our study aims to identify the key genes and biochemical pathways mediating pancreatitis and PDAC. The gene expression datasets were retrieved from the EMBL-EBI ArrayExpress and NCBI GEO database. A total of 172 samples of normal pancreatic tissue, 68 samples of pancreatitis, and 306 samples of PDAC were used in this study. The differentially expressed genes (DEGs) identified were used to perform downstream analysis for ontology, interaction, and associated pathways. Furthermore, hub gene expression was validated using the GEPIA2 tool and survival analysis using the Kaplan-Meier (KM) plotter. The potential druggability of the hub genes identified was determined using the Drug-Gene Interaction Database (DGIdb). Our study identified a total of 45 genes found to have altered expression levels in both PDAC and pancreatitis. Over-representation analysis revealed that protein digestion and absorption pathway, ECM-receptor interaction pathway, PI3k-Akt signaling pathway, and proteoglycans in cancer pathways as significantly enriched. Module analysis revealed 15 hub genes with 92 edges, of which 14 were found to be in the druggable genome category. Through bioinformatics analysis, we identified key genes and biochemical pathways disrupted in pancreatitis and PDAC. The results can provide new insights into targeted therapy and intervening therapeutically at an earlier stage can be used as an effective strategy to decrease the incidence and severity of PDAC.
Navigation of Frameless Fixation for Gammaknife Radiosurgery Using Fixed Augmented Reality
Authors: Moon Hyeong Cheol , Park Sang Joon , Kim Youngdeok , Kim Kyung Min , Kang Ho , Lee Eun Jung , Kim Min-Sung , Kim Jin Wook , Kim Yong Hwy , Park Chul-Kee , Kim Young Gyu , Dho Yun-Sik 
Published: September 2021

Abstract
Augmented reality (AR) offers a new medical treatment approach. We aimed to evaluate frameless fixation navigation using a 3D-printed patient model with fixed-AR technology for gammaknife radiosurgery. Fixed-AR navigation was developed using the inside-out method with visual inertial odometry algorithms, and the flexible Quick Response (QR) marker was created for object-feature recognition. Virtual 3D-patient models for AR-rendering were created via 3D-scanning utilizing TrueDepth and cone-beam computed tomography (CBCT) to generate a new GammaKnife IconTM model. A 3D-printed patient model included fiducial markers, and virtual 3D-patient models were used to validate registration accuracy. Registration accuracy between initial frameless fixation and re-fixation navigated fixed-AR was validated through visualization. The quantitative method was validated through set-up errors, fiducial marker coordinates, and high-definition motion management (HDMM) values. 3D-printed models and virtual models were correctly overlapped under frameless fixation. Virtual models from both 3D-scanning and CBCT were enough to tolerate the navigated frameless re-fixation. Although the CBCT virtual model consistently delivered more accurate results, 3D-scanning was sufficient. Frameless re-fixation accuracy navigated in virtual models had mean set-up errors within 1 mm and 1.5° in all axes. Mean fiducial marker differences from coordinates in virtual models were within 2.5 mm in all axes, and mean 3D errors were within 3 mm. Mean HDMM difference values in virtual models were within 1.5 mm of initial HDMM values. The variability from navigation fixed-AR is enough to consider repositioning frameless fixation without CBCT scanning for treating patients fractionated with large multiple metastases lesions (>3 cm) who have difficulty enduring long beam-on time. This system could be applied to novel radiosurgery navigation for frameless fixation with reduced preparation time.