bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new method for heat integration between nonrepeatable batches
Authors: Anastasovski Aleksandar 
Published: February 2021

AbstractHeat storage is an important part for heat integration between nonrepeatable batches. This article suggests a new approach in the design of heat storage exchange network for heat integration between nonrepeatable batches. This approach is built on the TRANSSHIPMENT method. The main idea is reusing the waste heat from stream segments that are designed to exchange heat with utilities. These extracted stream segments are added to every upcoming time slice as new energy streams. The possible heat exchange between extracted segments and existing streams in every Time Slice is based on the suggested algorithm which includes the main rules of the Pinch technology. All possible matches are potential heat storage units or subsystems. The efficiency of heat recovery increases if the schedule of nonrepeatable batches is repeated every day. That makes a great impact on the production costs. Otherwise, as it is in the given case study, the waste heat reduction is small and cannot support the investment for the solution. The reduction of hot utility in the presented case study is 43.5% and the reduction of cold utility is 12.1% in the start‐up period of the plant (58.94 hours).
Not so clonal asexuals: Unraveling the secret sex life ofArtemia parthenogenetica
Authors: Boyer Loreleï , Jabbour-Zahab Roula , Mosna Marta , Haag Christoph R. , Lenormand Thomas 
Published: February 2021

AbstractThe maintenance of sex is paradoxical as sexual species pay the “twofold cost of males” and should thus quickly be replaced by asexual mutants reproducing clonally. However, asexuals may not be strictly clonal and engage in “cryptic sex,” challenging this simple scenario. We study the cryptic sex life of the brine shrimp Artemia parthenogenetica, which has once been termed an “ancient asexual” and where no genetic differences have ever been observed between parents and offspring. This asexual species rarely produces males, which can hybridize with sexual females of closely related species and transmit asexuality to their offspring. Using such hybrids, we show that recombination occurs in asexual lineages, causing loss-of-heterozygosity and parent-offspring differences. These differences cannot generally be observed in field-sampled asexuals because once heterozygosity is lost, subsequent recombination leaves no footprint. Furthermore, using extensive paternity tests, we show that hybrid females can reproduce both sexually and asexually, and transmit asexuality to both sexually and asexually produced offspring in a dominant fashion. Finally, we show that, contrary to previous reports, field-sampled asexual females also rarely reproduce sexually (rate ∼2‰). Overall, most previously known facts about Artemia asexuality turned out to be erroneous. More generally, our findings suggest that the evidence for strictly clonal reproduction of asexual species needs to be reconsidered, and that rare sex and consequences of nonclonal asexuality, such as gene flow within asexuals, need to be more widely taken into account in more realistic models for the maintenance of sex and the persistence of asexual lineages.
Closing the Broadband Digital Divide: The Role of Utility‐Owned Fiber
Authors: Tong Calvin , Zimmerman Daniel , McClanahan Jim 
Published: February 2021

Digital redlining, defined as inequitable digital access for marginalized customer groups, is a reality in broadband. In a deregulated competitive market, internet service providers (ISPs) and carriers will deploy broadband in those areas promising the greatest potential market share and revenue. As a result, some areas, particularly rural or low‐income urban neighborhoods, are prone to be underserved, becoming “broadband deserts,” or areas with limited or no access to affordable broadband internet services. These areas are characterized as unserved (with coverage falling below 25/3 Mbps1) or underserved (with coverage falling below 100/20 Mbps) by broadband providers due to the area's unfavorable costs to deploy and build infrastructure relative to the predicted “take‐rates” (number of consumers that would subscribe for service), average revenues per subscriber, and associated returns on investment.
Effect of air pollution on health care expenditure: Evidence from respiratory diseases
Authors: Liu Ya‐Ming , Ao Chon‐Kit 
Published: February 2021

AbstractRecent reports show that at least 95% of the world's population is breathing polluted air. However, the impact of air quality on air pollution‐related medical expenditure and utilization is sparse. This study estimates the short‐term health care cost impacts of air pollution using a meteorological phenomenon—thermal inversion—as an instrumental variable for air quality. Using information on outpatient care for respiratory diseases from universal health insurance claim data in Taiwan during 2006–2012, our estimates suggest that a one‐unit reduction in the air quality index (AQI) leads to NT$2.3 billion (nearly US$74 million) of savings in respiratory‐related outpatient expenditure per year. Given that the average AQI is equal to 32 during our study period, completely removing air pollution would reduce the national health expenditure by approximately 8% annually. Our results provide the important implication that the cost of controlling air pollutant emissions can be offset by curtailing health care expenditure.
High Mobility Group Box 1 Release by Cholangiocytes Governs Biliary Atresia Pathogenesis and Correlates With Increases in Afflicted Infants
Authors: Mohanty Sujit K. , Donnelly Bryan , Temple Haley , Ortiz‐Perez Ana , Mowery Sarah , Lobeck Inna , Dupree Phylicia , Poling Holly M. , McNeal Monica , Mourya Reena , Jenkins Todd , Bansal Ruchi , Bezerra Jorge , Tiao Greg 
Published: February 2021

Background and Aims
Biliary atresia (BA) is a devastating cholangiopathy of infancy. Upon diagnosis, surgical reconstruction by Kasai hepatoportoenterostomy (HPE) restores biliary drainage in a subset of patients, but most patients develop fibrosis and progress to end‐stage liver disease requiring liver transplantation for survival. In the murine model of BA, rhesus rotavirus (RRV) infection of newborn pups results in a cholangiopathy paralleling that of human BA. High‐mobility group box 1 (HMGB1) is an important member of the danger‐associated molecular patterns capable of mediating inflammation during infection‐associated responses. In this study, we investigated the role of HMGB1 in BA pathogenesis.

Approach and Results
In cholangiocytes, RRV induced the expression and release of HMGB1 through the p38 mitogen‐activated protein kinase signaling pathway, and inhibition of p38 blocked HMGB1 release. Treatment of cholangiocytes with ethyl pyruvate suppressed the release of HMGB1. Administration of glycyrrhizin in vivo decreased symptoms and increased survival in the murine model of BA. HMGB1 levels were measured in serum obtained from infants with BA enrolled in the PROBE and START studies conducted by the Childhood Liver Disease Research Network. High HMGB1 levels were found in a subset of patients at the time of HPE. These patients had higher bilirubin levels 3 months post‐HPE and a lower survival of their native liver at 2 years.

Conclusions
These results suggest that HMGB1 plays a role in virus induced BA pathogenesis and could be a target for therapeutic interventions in a subset of patients with BA and high HMGB1.
Evolving Up‐regulation of Biliary Fibrosis–Related Extracellular Matrix Molecules After Successful Portoenterostomy
Authors: Kyrönlahti Antti , Godbole Nimish , Akinrinade Oyediran , Soini Tea , Nyholm Iiris , Andersson Noora , Hukkinen Maria , Lohi Jouko , Wilson David B. , Pihlajoki Marjut , Pakarinen Mikko P. , Heikinheimo Markku 
Published: February 2021

Successful portoenterostomy (SPE) improves the short‐term outcome of patients with biliary atresia (BA) by relieving cholestasis and extending survival with native liver. Despite SPE, hepatic fibrosis progresses in most patients, leading to cirrhosis and a deterioration of liver function. The goal of this study was to characterize the effects of SPE on the BA liver transcriptome. We used messenger RNA sequencing to analyze global gene‐expression patterns in liver biopsies obtained at the time of portoenterostomy (n = 13) and 1 year after SPE (n = 8). Biopsies from pediatric (n = 2) and adult (n = 2) organ donors and other neonatal cholestatic conditions (n = 5) served as controls. SPE was accompanied by attenuation of inflammation and concomitant up‐regulation of key extracellular matrix (ECM) genes. Highly overexpressed genes promoting biliary fibrosis and bile duct integrity, such as integrin subunit beta 6 and previously unreported laminin subunit alpha 3, emerged as candidates to control liver fibrosis after SPE. At a cellular level, the relative abundance of activated hepatic stellate cells and liver macrophages decreased following SPE, whereas portal fibroblasts (PFs) and cholangiocytes persisted. Conclusion: The attenuation of inflammation following SPE coincides with emergence of an ECM molecular fingerprint, a set of profibrotic molecules mechanistically connected to biliary fibrosis. The persistence of activated PFs and cholangiocytes after SPE suggests a central role for these cell types in the progression of biliary fibrosis.
Hippocampal beta oscillations predict mouse object‐location associative memory performance
Authors: Iwasaki Satoshi , Sasaki Takuya , Ikegaya Yuji 
Published: February 2021

AbstractMemorizing the locations of environmental cues is crucial for survival and depends on the hippocampus. We recorded local field potentials (LFPs) from the hippocampus of freely moving mice during an object location task. The power of beta‐band (23–30 Hz) oscillations increased immediately before approaching objects in a memory‐encoding phase. The exploration‐induced beta oscillations gradually decreased during the memory‐encoding session. Mice that exhibited stronger beta oscillation power exhibited better performance in the subsequent memory‐retrieval test. These results suggest that beta oscillations in the hippocampal CA1 region are involved in the memory encoding of object‐location associations.
Facilitators to healthy canteen policy implementation: A qualitative approach
Authors: McPherson Melinda , Lai Cheuk Chi , Leahy Deana , Wessell Adele , Srinivasan Saranya , Hanley Bridget , Peeters Anna , Palermo Claire 
Published: February 2021

AbstractIssue addressedGovernments across the world use guidelines and policy to support improving the quality and nutrition in school canteens, yet little is known about what makes for success in supporting school canteens. This study aimed to investigate the factors influencing the implementation of a healthy school canteen policy.MethodsA qualitative descriptive approach using interviews with a purposive sample of Victorian schools that had successfully implemented a healthy school canteen was conducted. Twelve interviews were conducted with principals (n = 4), assistant principal (n = 1), canteen managers (n = 5), food services manager (n = 1) and canteen staff members (n = 3) across six Victorian schools. Data were analysed using a content analysis approach.ResultsThree key themes explained the adoption of policy: Values – emphasising service over profit; Knowledge – understanding of nutrition and the policy; and Support – from within and external to the school.ConclusionsImplementation of school canteen policy is more likely to be achieved when a school can focus on the service and educative component of the policy and where there is a shared priority for healthy eating across the entire school community.So what?Creating a culture of service and community engagement with a healthy school canteen may increase policy implementation and should be the focus of future health promotion efforts.
A community‐supported weather and soil moisture monitoring database of the Roaring Fork catchment of the Colorado River Headwaters
Authors: Osenga Elise C. , Vano Julie A. , Arnott James C. 
Published: February 2021

AbstractLocal community interest in better understanding regional climate change impacts has motivated the establishment of a long‐term soil moisture and weather observation network in the Roaring Fork catchment of the Colorado River Headwaters. This catchment‐wide suite of 10 stations, installed between 2012 and 2020, collects frequent, fixed‐interval data on soil moisture, soil temperature, rain, air temperature, relative humidity, and (at some stations) snow across an elevational gradient from 1800 to 3680 m. In this paper we provide a description of the data this network provides, how data are accessed, and how this community‐supported effort has resulted in data that support mountain hydrology research with applications for resource management and climate change adaptation decision making. All data from this network are publicly available.
The impact of external governance and regulatory settings on the profitability of Islamic banks: Evidence from Arab markets
Authors: Athari Seyed Alireza , Bahreini Mahboubeh 
Published: February 2021

AbstractThis study specifically investigates the effects of external governance mechanisms and regulatory settings on the profitability of Islamic banks operating in the Arab markets from 2003 to 2017. The empirical results underscore that the external governance mechanism and its dimensions in particular the political stability, regulatory quality, rule of law, and control of corruption impact Islamic banks' profitability positively. However, the regulatory settings and its sub‐indices particularly the extent of disclosure and ease of shareholder suits have the opposite effect. Likewise, the results of traditional determinants indicate that the profitability of Islamic banks is shaped by the bank‐specific, industry‐specific, and country and global‐level determinants. Results are robust and consistent with alternative estimation procedures and also support for the negative and positive effect of voice and accountability external governance's dimension and inflation, respectively. The findings of this study have important policy implications for regulators, policymakers, and banks' managers.
iSPECTRON: A simulation interface for linear and nonlinear spectra with ab‐initio quantum chemistry software
Authors: Segatta Francesco , Nenov Artur , Nascimento Daniel R. , Govind Niranjan , Mukamel Shaul , Garavelli Marco 
Published: February 2021

AbstractWe introduce iSPECTRON, a program that parses data from common quantum chemistry software (NWChem, OpenMolcas, Gaussian, Cobramm, etc.), produces the input files for the simulation of linear and nonlinear spectroscopy of molecules with the Spectron code, and analyzes the spectra with a broad range of tools. Vibronic spectra are expressed in term of the electronic eigenstates, obtained from quantum chemistry computations, and vibrational/bath effects are incorporated in the framework of the displaced harmonic oscillator model, where all required quantities are computed at the Franck‐Condon point. The program capabilities are illustrated by simulating linear absorption, transient absorption and two dimensional electronic spectra of the pyrene molecule. Calculations at two levels of electronic structure theory, time‐dependent density functional theory (with NWChem) and RASSCF/RASPT2 (with OpenMolcas) are presented and compared where possible. The iSPECTRON program is available online at https://github.com/ispectrongit/iSPECTRON/ and distributed open source under the terms of the Educational Community License version 2.0 (ECL 2.0).
Ultrasmall Ag species decorated on α‐Fe2O3 nanorods toward high‐efficient photocatalytic degrading tetracycline hydrochloride in water
Authors: Zhou Xiangtong , Xi Haipeng , Li Chunmei , Dong Hongjun , Wang Xinling , Zhao Qilu , Zhang Juan , Yang Jing 
Published: February 2021

AbstractThe ultrasmall Ag species decorated on α‐Fe2O3 nanorods photocatalysts are prepared through a facile in situ photodeposition process. The obtained Ag/α‐Fe2O3 composite samples display more outstanding photocatalytic activity than original α‐Fe2O3 in the degradation of tetracycline hydrochloride (TC‐HCl) in water. The degradation rate constant of TC‐HCl over the Ag/α‐Fe2O3‐5 sample reaches up to 0.0118 min−1, which is about 6.21 times than that over original α‐Fe2O3 sample (0.0019 min−1). The structure characterizations, physicochemical properties, and photoelectrochemical measurements reveal that the visible light absorption ability and charge separation efficiency are improved dramatically owing to the decoration effect of ultrasmall Ag species on the surface of α‐Fe2O3 nanorods. The photocatalytic reaction mechanism investigations demonstrate that holes, ˙O2−, and ˙OH all are main active species and play important roles in the degradation process of TC‐HCl.
Liquid nitrogen for cryotherapy treatment for osteosarcoma of the middle femur: A case report
Authors: Liu Cheng , Shu Cuili 
Published: February 2021

AbstractBackgroundOsteosarcoma is the most common primary malignant bone tumor in children and adolescents. Cryotherapy liquid nitrogen has been used an adjuvant treatment for tumors for some decades.Case presentationA 23‐year‐old male patient was admitted to our hospital, mainly due to progressive pain in his left thigh, and confirmed osteosarcoma by local biopsy. A total length of 28 cm tumor bone was completely resected at the region of above and below lesion 3 cm under the guidance of MRI. After removed part of the tumor tissue, tumor bone was dealt with liquid nitrogen for 20 minutes. Finally, the bone was fixed with intramedullary needles for reconstruction. Three months after surgery, the X‐ray examination showed poor bone growth at both distal sides of osteotomy and disuse degeneration of knee joint. The patient was performed an incision on the lateral side of the distal left thigh to secure the locking plate, and followed up every 3 months. Two years after operation, there was no sign of local recurrence.ConclusionLiquid nitrogen for cryotherapy may be a feasible local therapy for large lesion of osteosarcoma in middle femur.
PKC‐β/Alox5 axis activation promotes Bcr‐Abl‐independent TKI‐resistance in chronic myeloid leukemia
Authors: Ma Dan , Liu Ping , Wang Ping , Zhou Zhen , Fang Qin , Wang Jishi 
Published: February 2021

AbstractBcr‐Abl independent resistance to tyrosine kinase inhibitor (TKI) is a crucial factor lead to relapse or acute leukemia transformation in chronic myeloid leukemia (CML). However, its mechanism is still unclear. Herein, we found that of nine common protein kinases C (PKCs), PKC‐β overexpression was significantly related with TKI resistance. Blockage of its expression in CD34+ cells and CML cell lines increased sensitivity to imatinib. Then, eighty‐four leukemia related genes were compared between TKI‐resistant CML cell lines with PKC‐β silenced or not. Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that Arachidonate 5‐lipoxygenase (Alox5) and its relative pathway mainly participated in the resistance induced by PKC‐β overexpression. It's also observed that Alox5 was increased not only in bone marrow biopsy but also in CD34+ cells derived from IM‐resistant CML patients. The signaling pathway exploration indicated that ERK1/2 pathway mediates Alox5 upregulation by PKC‐β. Meanwhile, we also proved that Alox5 induces TKI‐insensitivity in CML through inactivation of PTEN. In vivo experiment, PKC‐β elective inhibitor LY333531 prolonged survival time in CML‐PDX mice model. In conclusion, targeted on PKC‐β overexpression might be a novel therapy mechanism to overcome TKI‐resistance in CML.
Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant‐induced bronchodilation
Authors: Lu Ping , ElMallah Mai K. , Liu Zeyu , Wu Chan , Chen Jun , Lifshitz Lawrence M. , ZhuGe Ronghua 
Published: February 2021

AbstractBitter taste receptors (TAS2Rs) and their signaling elements are detected throughout the body, and bitter tastants induce a wide variety of biological responses in tissues and organs outside the mouth. However, the roles of TAS2Rs in these responses remain to be tested and established genetically. Here, we employed the CRISPR/Cas9 gene‐editing technique to delete three bitter taste receptors—Tas2r143/Tas2r135/Tas2r126 (i.e., Tas2r triple knockout [TKO]) in mice. The fidelity and effectiveness of the Tas2r deletions were validated genetically at DNA and messenger RNA levels and functionally based on the tasting of TAS2R135 and TAS2R126 agonists. Bitter tastants are known to relax airways completely. However, TAS2R135 or TAS2R126 agonists either failed to induce relaxation of pre‐contracted airways in wild‐type mice and Tas2r TKO mice or relaxed them dose‐dependently, but to the same extent in both types of mice. These results indicate that TAS2Rs are not required for bitter tastant‐induced bronchodilation. The Tas2r TKO mice also provide a valuable model to resolve whether TAS2Rs mediate bitter tastant‐induced responses in many other extraoral tissues.
Volunteer unrelated donor cell‐derived acute myeloid leukemia with RUNX1‐RUNX1T1
Authors: Hagiwara Shinya , Kusumoto Shigeru , Ito Asahi , Masaki Ayako , Shiraga Kazuhide , Tachita Takuto , Hirade Kentaro , Oiwa Kana , Suzuki Tomotaka , Kinoshita Shiori , Ri Masaki , Ito Yasuhiko , Komatsu Hirokazu , Inagaki Hiroshi , Iida Shinsuke 
Published: February 2021

AbstractA 15‐year‐old male was diagnosed with acute myeloid leukemia with t(6;9)(p23;q34), a chimeric DEK‐NUP214 fusion gene. He underwent allogeneic bone marrow transplantation (allo‐BMT) from an unrelated volunteer donor at first molecular remission. Approximately 5 years after allo‐BMT, multiple bone marrow aspirations showed increased blasts to 63%, which were positive for myeloperoxidase, CD13, CD33, CD56, and CD34. Surprisingly, t(8;21)(q22;q22.1), a chimeric RUNX1‐RUNX1T1 (not DEK‐NUP214) fusion gene, was detected with full donor chimerism. To our best knowledge, this is the first case of a volunteer unrelated donor cell‐derived acute myeloid leukemia harboring a chimeric RUNX1‐RUNX1T1 fusion gene.