bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Features, Prognosis, and Long-Term Response to Ranibizumab of Macular CNVs in Pattern Dystrophies Spectrum: A Pilot Study
Authors: Casillo Lorenzo , Tricarico Stefano , Contento Laura , Vingolo Enzo M. 
Published: April 2021

Introduction. To analyze the morphological and functional features of choroidal neovascularizations (CNVs) in eyes affected by pattern dystrophies (PD), evaluating their long-term response to intravitreal ranibizumab, and comparing them with CNVs in age-related macular degeneration (AMD). The mean goal is to identify possible disease biomarkers and to evaluate the long-term prognosis of CNVs in PD. Materials and Methods. A retrospective study of 42 patients with naïve CNV (26 PD and 16 AMD), for a total of 47 eyes (29 eyes in the PD group and 18 eyes in the AMD group). Each patient received a loading dose of ranibizumab (one monthly for three months) followed by pro re nata (PRN) reinjection protocol for a period of at least three years. Morphological OCT parameters (CRT, central retinal thickness; SRF, subretinal fluid; IRF, intraretinal fluid; SHRM, subretinal hyperreflective material; HRF, hyperreflective foci; HCD, hyperreflective crystalline deposits; cCT, central choroidal thickness; slCT, sublesional choroidal thickness; EZd, ellipsoid zone disruption; and best corrected visual acuity (BCVA in logMAR scale)) were reported at baseline and last follow-up. Results. At baseline, no significant differences were found between the two groups, except for choroidal thickness parameters that were significantly greater in the PD group (

p

= 0.009). Longitudinal PD analysis demonstrated reduction in BCVA (

p

= 0.009), decrease in CRT (

p

= 0.046), resolution of SRF in 61.6% of cases (

p

= 0.004) and SHRM in 30% (

p

= 0.034), and choroidal thinning both centrally (

p

= 0.004) and sublesional (

p

= 0.011) compared to baseline. At 3 years, the PD group received significantly more injections than the AMD (

p

= 0.011) and showed significantly thicker choroid (

p

= 0.033) and more frequent HRF (

p

= 0.006). Regarding the PD group, we found a negative correlation between age and choroidal thicknesses at baseline and at 3 years (

p

< 0.05); significant positive correlations were found between baseline BCVA and at 3 years (

p

< 0.001), BCVA at 3 years and IRF (

p

= 0.003) and SHRM at 3 years (

p

= 0.003); CRT baseline and CRT 3 years (

p

= 0.017); HCD at 3 years was associated with greater CRT (

p

= 0.04) and IRF at 3 years (

p

= 0.019). Conclusions. Early and long-term morphofunctional features of CNVs in PD and in AMD are overlapping. CNVs in PD have poorer long-term response to ranibizumab and higher choroidal thickness suggesting different pathogenetic and evolutionary mechanisms.
Impaired High‐Density Lipoprotein Function in Patients With Heart Failure
Authors: Emmens Johanna E. , Jia Congzhuo , Ng Leong L. , van Veldhuisen Dirk J. , Dickstein Kenneth , Anker Stefan D. , Lang Chim C. , Filippatos Gerasimos , Cleland John G. F. , Metra Marco , Voors Adriaan A. , de Boer Rudolf A. , Tietge Uwe J. F. 
Published: April 2021

Background
We recently showed that, in patients with heart failure, lower high‐density lipoprotein (HDL) cholesterol concentration was a strong predictor of death or hospitalization for heart failure. In a follow‐up study, we suggested that this association could be partly explained by HDL proteome composition. However, whether the emerging concept of HDL function contributes to the prognosis of patients with heart failure has not been addressed.

Methods and Results

We measured 3 key protective HDL function metrics, namely, cholesterol efflux, antioxidative capacity, and anti‐inflammatory capacity, at baseline and after 9 months in 446 randomly selected patients with heart failure from BIOSTAT‐CHF (A Systems Biology Study to Tailored Treatment in Chronic Heart Failure). Additionally, the relationship between HDL functionality and HDL proteome composition was determined in 86 patients with heart failure. From baseline to 9 months, HDL cholesterol concentrations were unchanged, but HDL cholesterol efflux and anti‐inflammatory capacity declined (both
P
<0.001). In contrast, antioxidative capacity increased (
P
<0.001). Higher HDL cholesterol efflux was associated with lower mortality after adjusting for BIOSTAT‐CHF risk models and log HDL cholesterol (hazard ratio, 0.81; 95% CI, 0.71–0.92;
P
=0.001). Other functionality measures were not associated with outcome. Several HDL proteins correlated with HDL functionality, mainly with cholesterol efflux. Apolipoprotein A1 emerged as the main protein associated with all 3 HDL functionality measures.

Conclusions
Better HDL cholesterol efflux at baseline was associated with lower mortality during follow‐up, independent of HDL cholesterol. HDL cholesterol efflux and anti‐inflammatory capacity declined during follow‐up in patients with heart failure. Measures of HDL function may provide clinical information in addition to HDL cholesterol concentration in patients with heart failure.
Duration of Antiplatelet Therapy Following Transcatheter Aortic Valve Replacement: Systematic Review and Network Meta‐Analysis
Authors: Kuno Toshiki , Yokoyama Yujiro , Briasoulis Alexandros , Mori Makoto , Iwagami Masao , Ando Tomo , Takagi Hisato , Bangalore Sripal 
Published: April 2021

Background
Although current guidelines recommend dual antiplatelet therapy (DAPT) for 3 to 6 months following transcatheter aortic valve replacement (TAVR), there are no studies directly comparing outcomes of different durations of DAPT following TAVR.

Methods and Results

PubMed, EMBASE, and Cochrane Database were searched through November 2020 to identify clinical studies that investigated single antiplatelet therapy versus DAPT use following TAVR. Studies using oral anticoagulants and antiplatelet therapy concomitantly were excluded. The DAPT group was subdivided by the duration of DAPT. We extracted the risk ratios (RRs) of major or life‐threatening bleeding, stroke, and all‐cause mortality. Four randomized controlled trials, 2 propensity‐score matched studies, and 1 observational study were identified, yielding a total of 2498 patients who underwent TAVR assigned to the single antiplatelet therapy group (n=1249), 3‐month DAPT group (n=485), or 6‐month DAPT group (n=764). Pooled analyses demonstrated that when compared with the single antiplatelet therapy group, the rates of major or life‐threatening bleeding were significantly higher in the 3‐ and 6‐month DAPT groups (RR [95% CI]=2.13 [1.33–3.40],
P
=0.016; RR [95% CI]=2.54 [1.49–4.33],
P
=0.007, respectively) with no difference between the 3‐month DAPT versus 6‐month DAPT groups. The rates of stroke and all‐cause mortality were similar among the 3 groups.

Conclusions
In this network meta‐analysis of antiplatelet therapy following TAVR, single antiplatelet therapy with aspirin had lower bleeding without increasing stroke or death when compared with either 3‐ or 6‐month DAPT.
Does Ventromedial Prefrontal Cortex Damage Really Increase Impulsiveness? Delay and Probability Discounting in Patients with Focal Lesions
Authors: Mok Jenkin N. Y. , Green Leonard , Myerson Joel , Kwan Donna , Kurczek Jake , Ciaramelli Elisa , Craver Carl F. , Rosenbaum R. Shayna 
Published: April 2021

Abstract
If the tendency to discount rewards reflects individuals' general level of impulsiveness, then the discounting of delayed and probabilistic rewards should be negatively correlated: The less a person is able to wait for delayed rewards, the more they should take chances on receiving probabilistic rewards. It has been suggested that damage to the ventromedial prefrontal cortex (vmPFC) increases individuals' impulsiveness, but both intertemporal choice and risky choice have only recently been assayed in the same patients with vmPFC damage. Here, we assess both delay and probability discounting in individuals with vmPFC damage (n = 8) or with medial temporal lobe (MTL) damage (n = 10), and in age- and education-matched controls (n = 30). On average, MTL-lesioned individuals discounted delayed rewards at normal rates but discounted probabilistic rewards more shallowly than controls. In contrast, vmPFC-lesioned individuals discounted delayed rewards more steeply but probabilistic rewards more shallowly than controls. These results suggest that vmPFC lesions affect the weighting of reward amount relative to delay and certainty in opposite ways. Moreover, whereas MTL-lesioned individuals and controls showed typical, nonsignificant correlations between the discounting of delayed and probabilistic rewards, vmPFC-lesioned individuals showed a significant negative correlation, as would be expected if vmPFC damage increases impulsiveness more in some patients than in others. Although these results are consistent with the hypothesis that vmPFC plays a role in impulsiveness, it is unclear how they could be explained by a single mechanism governing valuation of both delayed and probabilistic rewards.
Memory for Stimulus Duration Is Not Bound to Spatial Information
Authors: Kruijne Wouter , Olivers Christian N. L. , van Rijn Hedderik 
Published: April 2021

Abstract
Different theories have been proposed to explain how the human brain derives an accurate sense of time. One specific class of theories, intrinsic clock theories, postulate that temporal information of a stimulus is represented much like other features such as color and location, bound together to form a coherent percept. Here, we explored to what extent this holds for temporal information after it has been perceived and is held in working memory for subsequent comparison. We recorded EEG of participants who were asked to time stimuli at lateral positions of the screen followed by comparison stimuli presented in the center. Using well-established markers of working memory maintenance, we investigated whether the usage of temporal information evoked neural signatures that were indicative of the location where the stimuli had been presented, both during maintenance and during comparison. Behavior and neural measures including the contralateral delay activity, lateralized alpha suppression, and decoding analyses through time all supported the same conclusion: The representation of location was strongly involved during perception of temporal information, but when temporal information was to be used for comparison, it no longer showed a relation to spatial information. These results support a model where the initial perception of a stimulus involves intrinsic computations, but that this information is subsequently translated to a stimulus-independent format to be used to further guide behavior.
Neuronal classification from network connectivity via adjacency spectral embedding
Authors: Mehta Ketan , Goldin Rebecca F. , Marchette David , Vogelstein Joshua T. , Priebe Carey E. , Ascoli Giorgio A. 
Published: April 2021

Abstract
This work presents a novel strategy for classifying neurons, represented by nodes of a directed graph, based on their circuitry (edge connectivity). We assume a stochastic block model (SBM) in which neurons belong together if they connect to neurons of other groups according to the same probability distributions. Following adjacency spectral embedding of the SBM graph, we derive the number of classes and assign each neuron to a class with a Gaussian mixture model-based expectation maximization (EM) clustering algorithm. To improve accuracy, we introduce a simple variation using random hierarchical agglomerative clustering to initialize the EM algorithm and picking the best solution over multiple EM restarts. We test this procedure on a large (≈212–215 neurons), sparse, biologically inspired connectome with eight neuron classes. The simulation results demonstrate that the proposed approach is broadly stable to the choice of embedding dimension, and scales extremely well as the number of neurons in the network increases. Clustering accuracy is robust to variations in model parameters and highly tolerant to simulated experimental noise, achieving perfect classifications with up to 40% of swapped edges. Thus, this approach may be useful to analyze and interpret large-scale brain connectomics data in terms of underlying cellular components.
A quantitative view of the structure of institutional scientific collaborations using the example of Berlin
Authors: Akbaritabar Aliakbar 
Published: April 2021

Abstract
This paper examines the structure of scientific collaborations in Berlin as a specific case with a unique history of division and reunification. It aims to identify strategic organizational coalitions in a context with high sectoral diversity. We use publications data with at least one organization located in Berlin from 1996–2017 and their collaborators worldwide. We further investigate four members of the Berlin University Alliance (BUA), as a formerly established coalition in the region, through their self-represented research profiles compared with empirical results. Using a bipartite network modeling framework, we move beyond the uncontested trend towards team science and increasing internationalization. Our results show that BUA members shape the structure of scientific collaborations in the region. However, they are not collaborating cohesively in all fields and there are many smaller scientific actors involved in more internationalized collaborations in the region. Larger divides exist in some fields. Only Medical and Health Sciences have cohesive intraregional collaborations, which signals the success of the regional cooperation established in 2003. We explain possible underlying factors shaping the intraregional groupings and potential implications for regions worldwide. A major methodological contribution of this paper is evaluating the coverage and accuracy of different organization name disambiguation techniques.
A cross sectional study: The association between sleeping quality and stress among second and third medical students at the University of Jordan
Authors: Toubasi AA , Khraisat BR , AbuAnzeh RB , Kalbouneh HM 
Published: April 2021

Objective Medicine is considered one if not the most stressful educational field. Thus, the aim of this study is to investigate the prevalence of stress and poor sleeping quality among medical students and the association between them. Method This cross-sectional study was conducted at the University of Jordan on second- and third-year medical students. The questionnaire consisted of: 1) Demographics; 2) The assessment tools which were Pittsburgh Quality of Sleep Index (PSQI) and Kessler Psychological Distress Status (K10). Binary logistic regression, chi-square and linear regression were used to investigate the association between PSQI, K10, and their determinants. Results The mean for PSQI score was 6.76 ± 3.32. PSQI scores interpretation revealed that 61.7% of the 282 participants of this study were poor sleepers. Logistic regression results showed that only the category of not napping at all from the napping hours variable was significantly associated with sleeping quality. Furthermore, the mean of K10 scores was 24.5 ± 8.5. K10 scores revealed that 66.3% of the participants were stressed. Logistic regression results showed that gender and regular exercise were significantly associated with psychological distress. Additionally, chi-square test, logistic regression and linear regression showed that PSQI was significantly associated with K10 (P <0.01). Conclusions Stress and poor sleeping quality in medical students at the University of Jordan were highly prevalent and strongly associated. What determined PSQI was daytime napping, and for K10 were regular exercise and gender. Further investigations into stress and sleep quality in the Arabian region are needed.
Identification of predictors of the ovarian response to clomiphene citrate in infertile women with polycystic ovary syndrome: a prospective cohort study
Authors: Xia Hexia , Sun Xiaoli , Guan Haiyun , Zhang Ruixiu , Zhang Wei 
Published: April 2021

Objective To identify predictors of the ovarian response to clomiphene citrate (CC) in infertile patients with polycystic ovary syndrome (PCOS). Methods We performed a prospective cohort study of infertile patients with PCOS. The participants underwent assessments of their physical, endocrine, and metabolic characteristics, and treatment with CC at an initial dose of 50 mg/day and a maximum of 100 mg/day between days 3 and 7 of their menstrual cycles. Participants who ovulated were identified as responders and those who did not as non-responders. Results Of the 72 participants, 48 (66.7%) were identified as responders and 24 as non-responders. Sex hormone-binding globulin (SHBG) (odds ratio 1.022, 95% confidence interval: 1.000–1.045) was found to be associated with the ovarian response to CC using logistic multivariate regression analysis. Receiver operating characteristic analysis also showed that SHBG was a significant predictor of the response to CC (area under the curve 0.799). Conclusion We have shown that SHBG is the best prognostic indicator of an ovulatory response to CC. However, larger prospective studies, in which more variables are assessed, are required to confirm this finding and to identify appropriate cut-off values.
Roles of preoperative and early postoperative electrodiagnosis in brachial plexus injury patients undergoing nerve transfer operations: retrospective feasibility study
Authors: Son Woo Chul , Kim Jae Kwang , Kwon Sara , Kim Dae Yul 
Published: April 2021

Objective The purpose of this retrospective observational study was to assess the feasibility of electrodiagnostic parameters, perioperatively, and to discover optimal values as prognostic factors for patients with brachial plexus injury undergoing nerve transfer operations. Methods We retrospectively reviewed the records of 11 patients who underwent nerve transfer surgery. The patients underwent perioperative electrodiagnosis (EDX) before and approximately 6 months after surgery. We evaluated the compound muscle action potential (CMAP) ratio, motor unit recruitment, and their interval changes. To evaluate motor strength, we used the Medical Research Council (MRC) grade, 6 and 12 months after surgery. We evaluated the relationships between improved CMAP ratio, and motor unit recruitment and MRC grade changes 6 and 12 months postoperatively. Results All parameters increased significantly after surgery. The CMAP ratio improvement 6 months after surgery correlated with the MRC grade change from baseline to 12 months, with a correlation coefficient of 0.813. Conclusion EDX parameters improved significantly postoperatively, and the CMAP ratio improvement 6 months after surgery correlated with the clinical outcomes at 1 year. The results of perioperative EDX might help establish long-term treatment plans for patients who undergo nerve transfer surgery.
Hematuria and its repetition after initial control in patients receiving anti-coagulant: A prospective observational study
Authors: Hajikhani Ehsan , Ghahestani Seyyed Mohammad , Akhavizadegan Hamed , Karbakhsh Mojgan 
Published: April 2021

Objectives: Although Gross hematuria in patients receiving anticoagulants is not very common, it is one of the most common reasons of consulting with urologists. It is recommended to investigate urinary tract malignancies but simultaneous approach to anticoagulation and hematuria so as the optimum balance could be attained, is not clearly defined in the literature yet. We aim to answer pitfalls of hematuria management in anticoagulant receiving patients in this manuscript. Materials and methods: In a prospective case control study during 2017–2019, we observed and collected the data of patients receiving anticoagulant therapy and suffered from gross hematuria with coagulation parameters in prophylactic or therapeutic range in an academic hospital affiliated to Tehran University of Medical Sciences. SPSS 24th version was used for descriptive analysis of collected data. Results: Sixty-six patients encountered hematuria while receiving anticoagulant therapy. Although hematuria was more common in male patients, its recurrence was higher in female patients. It started mostly in first 72 h of therapy and was anticoagulant-dose dependent. Degree of hematuria was mostly mild or moderate by visual estimation and controlled easily by holding the anticoagulant therapy for less than 2 days. Anti-platelet therapy, urinary catheterization and patient’s activity did not have any effect on re-bleeding rate. Conclusion: Considering the fact that ruling out the urinary tract malignancy is mandatory in these patients, moderate and severe hematuria can be controlled simply by short term holding the anticoagulant therapy while continuing antiplatelet therapy albeit there is possibility to continue them in mild cases. Removing urinary catheters and decreasing the patient’s mobility are not recommended. In order to decrease the recurrence of hematuria, re-establishing anticoagulation with LMWH and non-Vitamin D dependent oral agents rather than continuing Heparin and Warfarin might be helpful.
Association of microRNA-125a with the clinical features, disease activity and inflammatory cytokines of juvenile-onset lupus patients
Authors: Eissa Eman , Morcos Botros , Abdelkawy Rania Fawzy Mahmoud , Ahmed Hanan H , Kholoussi Naglaa M 
Published: April 2021

Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with marked variation in its clinical presentation. Juvenile-onset SLE (jSLE) exhibits an aggressive clinical phenotype and severe complications. Dysregulated expression of microRNAs (miRs) in immune cells from patients with SLE has been found. We aim to evaluate the association of miR-125a with the clinical and laboratory characteristics, disease activity and inflammatory cytokines of jSLE patients. Methods 60 jSLE patients and 25 normal controls were involved in the study. The expression pattern of miR-125a was determined in plasma of all subjects using qRT-PCR. In addition, plasma levels of IL-17 and IFN-γ were examined using ELISA. The correlation of miR-125a expression with the clinical manifestations and disease activity of jSLE patients was analyzed. Also, its association with the inflammatory cytokines was investigated in jSLE patients. Results Our findings showed that miR-125a expression levels were significantly reduced in jSLE patients compared to normal controls ( p < 0.01) and these expression levels differed based on the clinical variability of patients. In addition, plasma levels of IL-17 and IFN-γ in jSLE patients were significantly higher than healthy controls ( p < 0.01). Finally, miR-125a expression had significant negative associations with each of SLEDAI-2K ( p < 0.01), SLICC ( p < 0.01), ESR ( p < 0.05), proteinuria ( p < 0.01) and IL-17 levels ( p < 0.01) in jSLE patients. Conclusion Our findings postulate that miR-125a could act as a candidate therapeutic target for its possible regulation of inflammation in jSLE patients.