bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Naturalistic Examination of the Acute Effects of High‐Potency Cannabis on Emotion Regulation Among Young Adults: A Pilot Study
Authors: Cavalli Jessica M. , Cuttler Carrie , Cservenka Anita 
Published: December 2024

ABSTRACTObjectiveDespite the popular public perception that cannabis use may be beneficial for relieving mental health symptoms, the empirical evidence remains equivocal. Various legal hurdles limit the ability to research whether acute high‐potency cannabis use affects mental health‐related processes. Therefore, the current study used a novel methodology to examine the acute effects of high‐potency cannabis flower on emotion regulation.MethodsUsing a remote, within‐subjects study design, 12 young adult (ages 21–30) cannabis users (who used cannabis at least 1 day/week on average across the past year) completed measures of emotion regulation while sober and acutely intoxicated in a counterbalanced manner. Participants completed the Emotional Go/No‐Go Task to measure implicit emotion regulation and a cognitive reappraisal task to assess explicit emotion regulation. For the intoxication condition, participants were observed smoking cannabis flower in their homes via videoconferencing.ResultsParticipants reported a more positive mood and decreases in anxiety while intoxicated. There was no evidence that acute high‐potency cannabis affected participants' implicit or explicit emotion regulation task performance.ConclusionsFuture research with larger samples might consider adopting this novel remote study design to assess the acute effects of high‐potency cannabis use on different measures of emotion regulation and other health outcomes.
Cost‐effectiveness analysis of 9‐valent human papillomavirus vaccine combined with screening for cervical cancer in Japan
Authors: Takamoto Naohiro , Aso Shotaro , Ishida Risa , Konishi Takaaki , Fushimi Kiyohide , Yasunaga Hideo 
Published: December 2024

AbstractObjectiveIn Japan, the current coverage rate of human papillomavirus (HPV) vaccination is only 30%, and the rate of biennial cervical screening is 40%. The Japanese Government has attempted to increase the coverage of HPV vaccination and cervical screening. We analyzed the cost‐effectiveness of the 9‐valent HPV vaccine and cervical screening in Japan.MethodsA yearly cycle Markov model with 15 health states was created to evaluate the cost‐effectiveness of the 9‐valent HPV vaccination and cervical screening in women aged 12–75 years. We considered four scenarios: 30% coverage of vaccination with 40% coverage of biennial screening (Scenario 1 representing the current Japanese situation), 70% (the highest proportion in 2013 in Japan) and 90% coverage of vaccination with 40% coverage of biennial screening (Scenarios 2 and 3, respectively), and 90% coverage of vaccination with 70% coverage of biennial screening (Scenarios 4). The incremental cost‐effectiveness ratio (ICER) was calculated as costs per quality‐adjusted life year (QALY) based on the perspective of the healthcare payer and compared with the benchmark for willingness to pay in Japan (41 700 USD per QALY). The cumulative morbidity and mortality in each scenario were analyzed using the Markov model.ResultsCompared with Scenario 1, the ICERs of Scenarios 2, 3, and 4 were 5382, 5321, and 8524 USD/QALY, respectively, which were lower than the benchmark for willingness to pay. As the coverage of HPV vaccination and cervical screening increased, the cumulative morbidity and mortality decreased.ConclusionIncreasing the coverage of the 9‐valent HPV vaccination and cervical screening is cost‐effective in Japan.
What is the origin of the normal ranges of blood cell counts? An evolutionary perspective
Authors: Zala Manon , Alcazer Vincent , Largeaud Laetitia , Sujobert Pierre 
Published: December 2024

AbstractBackgroundThe normal values of the complete blood count are part of the foundational medical knowledge that is seldom questioned due to their well‐established nature. These normal values are critical for optimal physiological function while minimizing the harmful consequences of an excessive number of blood cells. Thus, they represent an evolutionary trade‐off likely shaped by natural selection if they significantly influence individual fitness and exhibit heritability.MethodsOn the basis of the analysis of normal blood count values of 94 mammalian species, we discovered that certain parameters are strongly associated with diet, habitat, and lifespan.ResultsCarnivorous mammals had higher hemoglobin levels than vegetarians, and aquatic mammals displayed red blood cell parameters probably selected to enhance for the diving capacities. Body weight influenced platelet counts and innate immune cells, with lighter animals having higher platelet counts and larger animals showing elevated monocytes and neutrophils.ConclusionsBy treating the history of life as an experiment, we have discerned some evolutionary constraints likely contributing to the selection for optimal trade‐offs in blood cell count.
Central nervous system posttransplant lymphoproliferative disorder following allogeneic hematopoietic stem cell transplantation successfully treated with combination therapy of acalabrutinib and immunochemotherapy: A case report and literature review
Authors: Zheng Peihao , Xu Teng , Zuo Xiaona , Ke Xiaoyan , Hu Kai 
Published: December 2024

AbstractHere, we report a case of Epstein‐Barr virus‐positive central nervous system‐post‐transplant lymphoproliferative disorder (CNS‐PTLD) patient who failed to achieve complete metabolic remission (CMR) after successively trying a methotrexate‐based regimen combined with orelabrutinib or whole‐brain radiotherapy and encountered intracranial hemorrhage during orelabrutinib treatment. Ultimately, the patient achieved CMR after one cycle of acalabrutinib in combination with temozolomide, teniposide, liposomal doxorubicin, dexamethasone, and rituximab (TEDDi‐R). Following another cycle of TEDDi‐R treatment, he has been receiving acalabrutinib maintenance up to now and remained in CMR. The case may provide an effective treatment option for CNS‐PTLD patients in clinical practice.
Potential Evolutionary Convergence in Trophic Adaptations of Two Booidean Snake Lineages as Evidenced by Skull Morphology
Authors: Seneci Lorenzo , Hall Alexander S. , Glaw Frank , Scherz Mark D. 
Published: December 2024

ABSTRACTBooidean snakes are a diverse and widespread lineage with an intriguing evolutionary and biogeographic history. By means of cranial morphology and osteology, this study investigates the evolutionary convergence in the Neotropical genera Boa and Corallus on the one hand and the Malagasy clade comprising Acrantophis and Sanzinia on the other. We hypothesize that the mostly arboreal Corallus and Sanzinia present larger jaws and longer teeth to keep hold of the prey and resist gravity and torsional forces acting on their skull while hanging from branches, while terrestrial genera such as Acrantophis show thinner jaws with shorter teeth because they can rely on the full length of their coils to immobilize and constrict the prey together with a substrate that supports the whole of their body. Overall, we highlight how booidean snakes can serve as intriguing subjects for the study of contingency, determinism, and opportunity in the evolution of distant lineages both phylogenetically and geographically. We also provide the first complete description of the skull of Boa constrictor.
A Dark Horse: Colonial System of Integration in Ctenostome Bryozoans (Gymnolaemata: Ctenostomata)
Authors: Shunatova Natalia , Zhidkov Maxim 
Published: December 2024

ABSTRACTThe colonial system of integration (CSI) provides intracolonial nutrient supply in many gymnolaemate bryozoans. In Ctenostomata, its presence is known for species with stolonal colonies, for example, vesicularioideans, but its structure is almost unexplored. The CSI is thought to be absent in alcyonidioideans and other ctenostomes. Here, we present the first detailed description of the CSI ultrastructure in both autozooids and kenozooids of two vesicularioideans, Buskia nitens and Amathia gracilis, and two alcyonidioideans, Alcyonidium hirsutum and Flustrellidra hispida. We revealed differences in the endocyst structure: in studied alcyonioidioideans, it comprises the epidermis, extracellular matrix and coelomic lining, while in the studied vesicularioideans, it includes only the epidermis. In vesicularioidean autozooids, the main CSI cord and the most distal part of the muscular funiculus originate together as a single structure near the caecum apex. However, at a short distance basally, they separate and run to different sites: the main CSI cord reaches the communication pore, and the muscular funiculus attaches to the cystid wall in the proximal part of the autozooids. The CSI in alcyonidioidean autozooids includes a central part, comprising several strands running from the caecum and pylorus to the cystid walls, and a peripheral part, which is located between the epidermis and peritoneum of the cystid walls and reaches the communication pores. The autozooidal CSI in the studied alcyonidioids never reaches kenozooidal communication pores. Nevertheless, the CSI is present in kenozooids of F. hispida; its structure corresponds to that of the peripheral part of the CSI in autozooids. These findings suggest that the CSI likely originated rather early in bryozoan evolution, and its putative initial function is nutrient transport to budding sites and zooids undergoing degeneration‐regeneration cycle.
Comparison of Marker‐Based RSA and CT‐RSA for Analyzing Micromotions After Distal Radius Osteotomy: A 1‐Year Retrospective Study of 24 Patients
Authors: Angelomenos Vasileios , Sandberg Olof , Shareghi Bita , Ullman Michael 
Published: December 2024

ABSTRACTRadiostereometric Analysis (RSA) is the most accurate method for determining early micromotions of orthopedic implants. Computed Tomography Radiostereometric Analysis (CT‐RSA) is a method that can be used to determine implant and bone micromovements using low‐dose CT scans. This study aimed to evaluate the reliability of the CT‐RSA method in measuring the interfragmental mobility in patients who have undergone a correction osteotomy due to a malunited distal radius fracture. Twenty‐four patients were included and operated with a radiolucent volar plate. Markers were embedded in the plate and bone. RSA and CT examinations were obtained postoperatively up to 1‐year postoperative. Micromovements of the distal radius segment relative to the proximal were compared between the methods with paired analysis and Bland–Altman plots. The limits of clinical significance were: dorsal/volar tilt < 10°, radial shortening < 5 mm, radial inclination ≥ 15°, and radial shift < 5 mm. For the dorsal/volar tilt, the paired analysis between the two methods, showed a mean difference (95% CI) of −0.06° (−0.67 to 0.55), for radial compression‐0.04 mm (−0.09 to 0.01), for radial inclination 0.21° (−0.06 to 0.48), and for radial shift −0.07 mm (−0.21 to 0.07). The paired analysis for micromotions showed that the thresholds of clinical significance are excluded from the difference's 95% CI. The Bland–Altman plots showed comparable results up to 1 year, considering clinically relevant thresholds. In conclusion, the CT‐RSA method is comparable to that of marker‐based RSA in measuring micromotions after wrist osteotomy, as the differences between the methods are not clinically significant.
Complications that arise with nasogastric tubes after hospitalization in the pediatric population: A mixed methods systematic review
Authors: Mekhuri Samantha , Dussah Naomi , Quet Julie , Sampson Margaret , O'Hearn Katie , Loree Sara , Orkin Julia , Keilty Krista , Chu Stephanie , Major Nathalie , Amin Reshma 
Published: December 2024

AbstractChildren use nasogastric tubes (NGTs) to ensure optimum nutrition and medication delivery when oral feeding fails or when they experience faltering growth. Although this method is less invasive, children may experience complications associated with NGTs. There is a gap in the literature regarding the types and prevention of complications of NGTs in the pediatric population at home. This review determines at‐home complications associated with NGTs in the pediatric population (aged 0–18 years) and the type of education and support provided to caregivers. Databases MEDLINE, Embase using the Ovid interface, and CINAHL using the EBSCOhost interface were searched for relevant studies from January 1946 to November 2022. Twenty‐four articles were found, of which 16 studies with 902 children with NGTs feeding were systematically reviewed. Two themes emerged: (1) prevalence and types of NGT complications and (2) preventable complications and education/management strategies for prevention. Seven studies reported main complications of vomiting, retching and gagging, nausea, aspiration, local granulation tissue, and inadvertent removal, with two studies reporting no complications. Most complications were managed at home, suggesting caregivers were able to address issues without seeking additional medical intervention. Key recommendations to mitigate complications included training caregivers in NGT management, troubleshooting common complications, and evaluating caregiver competency before discharge. This systematic review emphasized the need for structured training programs to improve caregiver competence and safety practices, highlighting key areas for clinical improvement, including caregiver education, reducing at‐home complications, and standardizing care for children using NGTs.
Effects of Globularia cordifolia on colon cancer cells: antioxidant activity, inflammatory cytokine analysis and molecular docking studies
Authors: Torunoglu Emine Incilay , Aytar Erdi Can , Aydın Betul , Durmaz Alper , Balpınar Özge , Ertuğrul Muhammed Sait , Yarım Gül Fatma 
Published: December 2024

AbstractBACKGROUNDThe present study aimed to comprehensively evaluate the anticancer, anti‐inflammatory, and antioxidant properties of Globularia cordifolia L. samples. The plant material was collected and extracted using the maceration method. Antioxidant activities were assessed through DPPH (i.e. 2,2‐diphenyl‐1‐picrylhydrazyl) and iron chelation assays, whereas phenolic and flavonoid contents were measured using spectrophotometric methods. Gas chromatography‐mass spectrometry analysis was performed to identify biologically active compounds. The cytotoxic effect on colon cancer cells was evaluated using MTT [i.e. 2,3‐bis‐(2‐methoxy‐4‐nitro‐5‐sulfophenyl)‐2H‐tetrazolium‐5‐carboxanilide] assays, and inflammatory cytokine levels were measured through an enzyme‐linked immunosorbent assay. Molecular docking studies investigated the interactions of bioactive compounds with the 4UYA protein, and ADME (i.e. absorption, distribution, metabolism, excretion and toxicity) modeling predicted their toxicity.RESULTSThe study revealed that the extract exhibited strong antioxidant activity with a median 50% inhibitory concentration (IC50) value of 39.48 ± 2.15 μg mL−1 in the DPPH assay and an effective iron chelation capacity with an IC50 value of 4.28 ± 0.19 mg mL−1. The total phenolic content was 662.51 ± 20.95 mg gallic acid equivalents g−1, and the flavonoid content was 114.99 ± 0.51 mg quercetin equivalents g−1, demonstrating the extract's richness in phenolic and flavonoid compounds. Significant antiproliferative effects were observed in colon cancer cells at a dose of 250 μg mL−1. Inflammatory cytokine analysis indicated a reduction in pro‐inflammatory responses. Molecular docking studies showed strong binding affinities between the bioactive compounds and the 4UYA protein, suggesting the mechanisms of action.CONCLUSIONThe findings indicate that G. cordifolia extract exhibits strong antioxidant, anti‐inflammatory and antiproliferative properties, making it a promising biomolecular agent for colon cancer therapy. The high phenolic and flavonoid contents, combined with the bioactive compounds' interactions with key molecular targets, underscore its potential therapeutic applications. © 2024 Society of Chemical Industry.
“Grafting to” Rubber Composite for Elastic Dielectric Material
Authors: Bazliah Dinda , Hong Qi‐An , Laysandra Livy , Chiu Yu‐Cheng 
Published: December 2024

AbstractIn addition to traditional rubber applications, 1,4‐cis‐polyisoprene (cis‐PI) has been utilized in wearable electronics. While synthetic PI typically exhibits lower durability compared to natural rubber (NR), high‐molecular‐weight cis‐PI compensates by offering improved mechanical properties and chemical resistance. The group proposes using a commercial cis‐PI with high molecular weight of 250 000 g mol−1 (PI250K‐C) grafted onto modified nanoparticle structures including silicon dioxide (mSiO2), rutile titanium dioxide (mRTiO2), and anatase titanium dioxide (mATiO2) as an insulator in organic field effect transistors (OFETs) due to its naturally low dielectric constant. The nanoparticles are pretreated with a coupling agent to improve adhesion and prevent aggregation. Rubber composite films, designated X%‐mY‐PI250K‐C (where X = 10, 20, 30% and Y = mSiO2, mRTiO2, mATiO2), are fabricated using sulfur vulcanization. The modified films demonstrate excellent mechanical stress (1.15 ± 0.1 MPa) and elasticity, enduring 50 loading–unloading cycles without residual strain. In contrast, rubber composites produced from simple blending show half the mechanical stress at 0.7 ± 0.3 MPa, which is attributed to nanoparticle agglomeration observed in SEM and EDX results. Additionally, mRTiO2 nanoparticles significantly increase the dielectric constant of PI250K‐C from 2.12 to 12.93, enhancing electrical performance for TFT applications. This study underscores the effectiveness of the “grafting to” approach for producing robust rubber composites, highlighting the importance of nanoparticle selection and fabrication precision for stretchable organic electronics.
Exploring Cross‐Link Density and Additive Effects on Mechanical and Morphological Behaviors of Cross‐Linked Polymers
Authors: Keya Kamrun N. , Li Zhaofan , Xu Lan , Xia Wenjie 
Published: December 2024

AbstractCross‐linked thermoset polymeric materials are widely used in various engineering applications due to their excellent mechanical properties, thermal stability, and chemical resistance. Recent research highlights the role of cross‐link density and additives in influencing segmental dynamics and thermomechanical behavior of polymers. This study employs coarse‐grained molecular dynamics (CG‐MD) simulations to explore the thermomechanical and morphologic behaviors of cross‐linked polymers with molecular additives. Specifically, it is systematically investigated how cross‐link density (c) and different additive concentrations (m) affect key glass‐forming characteristics, along with the resulting changes in mechanical and morphologic properties of network materials as they approach their glass transition temperatures (Tg). Relatively weaker interaction between the polymer network and additives can lead to additive aggregation, significantly affecting the morphology and Tg as the m increases. Increasing c leads to an increase in both Tg and fragility while increasing m decreases them. The simulation reveals that both c and m moderately influence the mechanical properties (i.e., shear and tensile modulus) of cross‐linked polymers with additives. This study provides valuable insights into how cross‐link density and additive concentrations influence glass‐forming and morphological behaviors, offering a molecular design strategy for developing advanced cross‐linked thermosets.
1D Covalent Organic Frameworks with Tunable Dual‐Cobalt Synergistic Sites for Efficient CO2 Photoreduction
Authors: Xia Shu‐Kun , Liu Yong , Zhu Ruo‐Meng , Feng Jing‐Dong , Han Wang‐Kang , Gu Zhi‐Guo 
Published: December 2024

AbstractDiatomic catalysts enhance photocatalytic CO2 reduction through synergistic effects. However, precisely regulating the distance between two catalytic centers to achieve synergistic catalysis poses significant challenges. In this study, a series of one‐dimensional (1D) covalent organic frameworks (COFs) are designed with adjustable micropores to facilitate efficient CO2 photoreduction. CO2 molecules are anchored between dual‐cobalt centers within micropores, thus effectively reducing their activation energy and initiating the photocatalytic process. Additionally, the formation of *COOH intermediates is significantly influenced by the coordination microenvironment around dual‐cobalt sites. Notably, COF‐Co‐N4 exhibited remarkable CO2 photoreduction activity with a CO evolution rate of 110.3 µmol·g−1·h−1, which surpasses most of previously reported single‐atom‐site photocatalysts. Comprehensive characterization and density functional theory (DFT) calculations revealed that 1D COFs with dual‐cobalt sites possess the ability to anchor CO2 molecules, thereby enhancing the efficacy of synergistic catalysis. Simultaneously, COF‐Co‐N4 with quadruple nitrogen coordination significantly reduced the energy barrier of crucial *COOH intermediate, facilitating efficient photocatalytic CO2 reduction. This study meticulously modulated the coordination microenvironment surrounding dual‐cobalt synergistic sites, providing new insight into the design of high‐performance photocatalysts.
Sulfonated Styrene‐Grafted Polyvinylidene Fluoride Copolymers for Proton Exchange Membranes for AQDS/Bromine Redox Flow Batteries
Authors: Niccolai Francesca , Guazzelli Elisa , Cesari Andrea , El Koura Zakaria , Pucher Ilaria , Galli Giancarlo , Martinelli Elisa 
Published: December 2024

AbstractThis study presents the preparation and electrochemical testing of sulfonated styrene‐grafted poly(vinylidene fluoride) (pVDF) copolymers as proton exchange membranes (PEMs) for semi‐organic redox flow batteries (RFBs) based on 9,10‐anthraquinone‐2,7‐disulfonic acid (AQDS)/bromine. The copolymers are synthesized via a two‐step procedure, involving i) atom transfer radical polymerization of styrene (Sty) for the grafting to the pVDF backbone and ii) the sulfonation of the polystyrene grafted side chains. Copolymers with different amounts of sulfonated styrene (SSty) in the side chains (i.e., degree of sulfonation (DS)) are obtained and used for the preparation of PEMs by solution casting. The PEMs are characterized to assess their thermal, mechanical, water absorption, and ion exchange properties, to evaluate the effect of DS on membrane properties, and to select the membrane with the best overall performance for application in single cell tests. Electrochemical testing reveals that the pVDF‐g‐(Sty26‐co‐SSty14) membrane exhibits low crossover of redox species, favorable ohmic resistance, and energy efficiency. Results from single cell tests, as compared with commercial benchmarks such as Nafion 115 and Aquivion E87‐12s, highlight the potential of such copolymers as alternative membranes for RFBs.