bluuebunny/crossref_metadata_2025_split huggingface dataset:
The fMRI signature of acute catatonic state and its response to benzodiazepines
Authors: Parekh Pravesh , Gozi Anirban , Reddi Venkata Senthil Kumar , Saini Jitender , John John P. 
Published: March 2021

AbstractWe report for the first time, functional MRI markers of the acute retarded catatonic state and its response to benzodiazepines.In this cross-sectional MRI study, we have compared the resting state whole-brain, within-network and seed (left precentral gyrus)-to-voxel connectivity, as well as cortical complexity between a sample of patients in acute retarded catatonic state (n = 15) and a demographically-matched healthy control sample (n = 15). Additionally, we examined whether the above variables were different between responders (n = 9) and non-responders (n = 6) to lorazepam.Acute retarded catatonia was characterized by reduced functional connectivity, most robustly within the sensorimotor network, diffuse long-range hyperconnectivity, and seed (left precentral gyrus)-to-voxel hyperconnectivity in the frontoparietal and cerebellar regions. The lorazepam responders showed long-range as well as seed-to-voxel functional hyperconnectivity in comparison to the non-responders. Seed (left precentral gyrus)-to-voxel connectivity was positively correlated to the catatonia motor ratings. The catatonia sample showed a cluster of reduced vertex-wise cortical complexity in the right insular cortex and contiguous areas.We have identified neuroimaging markers that characterize the acute retarded catatonic state and predict treatment response. We discuss how these novel findings have important translational implications for understanding the pathophysiology of catatonia and for predicting treatment response to benzodiazepines.
Impact of a Population-based Systems Approach on Evidence-based Care for Medicaid-insured Pregnant and Postpartum Women: A Quasi-Experimental Study
Authors: Roman Lee Anne , Raffo Jennifer E. , Strutz Kelly L. , Luo Zhehui , Johnson Melinda , VanderMeulen Peggy , Henning Susan , Baker Dianna , Titcombe Claire , Meghea Cristian I. 
Published: March 2021

AbstractIntroductionEvidence-based enhanced prenatal/postnatal care (EPC) programs for Medicaid-insured women have significant positive effects on care and health outcomes. However, EPC enrollment rates are typically low, enrolling less than 30% of eligible women. This study investigated the effects of a population-based systems approach on timely EPC participation and other health care utilization.MethodsThis quasi-experimental, population-based, difference-in-difference study used linked birth certificates, Medicaid claims, and EPC data from complete statewide Medicaid birth cohorts retrieved from 2009-2017 and analyzed in 2019-20. System strategies included cross-agency leadership, clinical-community linked practices, Community Health Worker care, mental health coordination, and patient empowerment. Outcomes included EPC participation and early enrollment, prenatal care adequacy, emergency department contact, and postpartum care.ResultsPrenatal EPC (7.4 absolute percentage points; 95% CI: 6.3—8.5) and first trimester EPC, (12.4; 95% CI: 10.2—14.5) increased among women served by practices that co-located EPC resources, relative to the comparator group. First trimester EPC improved in the county (17.9; 95% CI: 15.7—20.0); ED decreased in the practices (−11.1; 95% CI: -12.3— -9.9) and postpartum care improved (7.1; 95% CI: 6— 8.2) in the county. EPC participation for Black women served by the practices improved (4.4; 95% CI: 2.2—6.6), as well as early EPC (12.3; 95% CI: 9.0—15.6) and postpartum visits (10.4; 95% CI: 8.3—12.4).ConclusionsA population systems approach improved EPC participation and service utilization for Medicaid-insured women in a county population, for those in practices that co-located EPC resources, and for Black women.
Human IgG and IgA responses to COVID-19 mRNA vaccines
Authors: Campillo-Luna Julian , Wisnewski Adam V , Redlich Carrie A 
Published: March 2021

ABSTRACTSARS-CoV-2 spike antigen-specific IgG and IgA elicited by infection mediate viral neutralization and are likely an important component of natural immunity, however, limited information exists on vaccine induced responses. We measured COVID-19 mRNA vaccine induced IgG and IgA in serum serially, up to 80 days post vaccination in 4 subjects. Spike antigen-specific IgG levels rose exponentially and plateaued 21 days after the initial vaccine dose. After the second vaccine dose IgG levels increased further, reaching a maximum approximately 7-10 days later, and remained elevated (average of 78% peak levels) during the additional 20-50 day follow up period. COVID-19 mRNA vaccination elicited spike antigen-specific IgA with similar kinetics of induction and time to peak levels, but more rapid decline in serum levels following both the 1st and 2nd vaccine doses (<23% peak levels within 80 days of the initial shot). The data demonstrate COVID-19 mRNA vaccines effectively induce spike antigen specific IgG and IgA and highlight marked differences in their persistence in serum.
COVID-19 antibody seroprevalence in Duhok, Kurdistan Region, Iraq: A population-based study
Authors: Hussein Nawfal R , Balatay Amer A , Naqid Ibrahim A , Jamal Shakir A , Rasheed Narin A , Ahmed Alind N , Salih Reving S , Mahdi Ahmed S , Mansour Sabeeha A , Mahdi Shaveen , Ibrahim Nashwan , Musa Dildar H , Saleem Zana SM. 
Published: March 2021

AbstractObjectiveThis population-based study aimed to evaluate the seroprevalence of antibodies to SARS-CoV-2 in Duhok City, Kurdistan Region of Iraq.MethodsWe analyzed the national COVID-19 database that contains data regarding COVID-19 testing, management, and clinical outcomes in Duhok. For this study, different subdistricts within each district of Duhok were considered distinct clusters. Blood samples were collected from and questionnaires were administered to eligible and consenting participants who were members of different families from the subdistricts. Immunoassays were conducted to detect antibodies against SARS-CoV-2, and the associations between certain variables were investigated.ResultsThe average number cases of COVID-19 before November 2020 was 23141 ± 4364, which was significantly higher than the average number of cases between November 2020 and February 2021 (3737 ± 2634; P = 0.001). A total of 743 individuals agreed to participate and were enrolled in the study. Among the participants, 465/743 (62.58%) were found to have antibodies against severe acute respiratory syndrome coronavirus 2. Among the participants with antibodies, 262/465 (56.34%) denied having any history of COVID-19-related symptoms. The most common symptom was fever (81.77%), followed by myalgia (81.28%). We found that antibody levels increased steadily with age (Pearson correlation coefficient = 0.117; P = 0.012). A significant association was found between antibody levels and the presence of symptoms (P = 0.023; odds ratio = 1.0023; 95% confidence interval = 1.0002-1.0061).ConclusionsA significant reduction in the number of COVID-19 cases was observed. This might be due to the high prevalence of SARS-CoV-2 antibodies in Duhok. However, infection-prevention measures should be followed as it remains unclear whether acquired immunity is protective against reinfection. It expected that the infection rates during the next wave will not be as high as the first wave due to the high infection rate in the society.
Vascular Comorbidities Worsen Prognosis of Patients with Heart Failure Hospitalized with COVID-19
Authors: Mok Jacob , Malpartida Juan , O’Dell Kimberly , Davis Joshua , Gao Cuilan , Manyam Harish 
Published: March 2021

ABSTRACTBackgroundPrior diagnosis of heart failure (HF) is associated with increased length of hospital stay (LOS) and mortality from Coronavirus disease-2019 (COVID-19). Associations between substance use, venous thromboembolism (VTE), or peripheral arterial disease (PAD) and its effects on LOS or mortality in patients with HF hospitalized with COVID-19 remains unknown.ObjectiveThis study identified risk factors associated with poor in-hospital outcomes among patients with HF hospitalized with COVID-19.MethodsCase control study was conducted of patients with prior diagnosis of HF hospitalized with COVID-19 at an academic tertiary care center from January 1, 2020 to February 28, 2021. Patients with HF hospitalized with COVID-19 with risk factors were compared with those without risk factors for clinical characteristics, length of stay (LOS), and mortality. Multivariate regression was conducted to identify multiple predictors of increased LOS and in-hospital mortality in patients with HF hospitalized with COVID-19.ResultsTotal of 211 HF patients were hospitalized with COVID-19. Females had longer LOS than males (9 days vs. 7 days; p < 0.001). Compared with patients without peripheral arterial disease (PAD) or ischemic stroke, patients with PAD or ischemic stroke had longer LOS (7 days vs. 9 days; p = 0.012 and 7 days vs. 11 days, p < 0.001; respectively). Older patients (aged 65 and above) had increased in-hospital mortality compared to younger patients (Adjusted OR: 1.04; 95% CI: 1.00 – 1.07; p = 0.036). VTE increased mortality more than three-fold in patients with HF hospitalized with COVID-19 (Adjusted OR: 3.33; 95% CI: 1.29 – 8.43; p = 0.011).ConclusionVascular diseases increase LOS and mortality in patients with HF hospitalized with COVID-19.KEY QUESTIONSWhat is already known about this subject?- Prior diagnosis of heart failure (HF) increases LOS and mortality in patients admitted to the hospital for COVID-19- Antiplatelet, anticoagulation, and statin therapy decreased venous thromboembolism (VTE) in patients admitted for COVID-19What does this study add?- This study showed that patients with COVID-19, HF, and VTE had a higher mortality rate than patients with COVID-19 and either HF or VTE, or patients with HF and/or VTE who did not have COVID-19.- This study showed that patients with HF hospitalized with COVID-19 had greater length of stay with prior diagnosis of peripheral arterial disease (PAD) or ischemic strokeHow might this impact on clinical practice?- Our findings demonstrate clinical relevance by showing supportive evidence for antiplatelet, anticoagulation, and statin therapy in HF patients hospitalized with COVID-19
Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface
Authors: Li Kathy K , Woo Y. Mun , Stirrup Oliver , Hughes Joseph , Ho Antonia , Da Silva Filipe Ana , Johnson Natasha , Smollett Katherine , Mair Daniel , Carmichael Stephen , Tong Lily , Nichols Jenna , Aranday-Cortes Elihu , Brunker Kirstyn , Parr Yasmin A. , Nomikou Kyriaki , McDonald Sarah E , Niebel Marc , Asamaphan Patawee , Sreenu Vattipally B , Robertson David L , Taggart Aislynn , Jesudason Natasha , Shah Rajiv , Shepherd James , Singer Josh , Taylor Alison H.M. , Cousland Zoe , Price Jonathan , Lees Jennifer S. , Jones Timothy P.W. , Lopez Carlos Varon , MacLean Alasdair , Starinskij Igor , Gunson Rory , Morris Scott T.W. , Thomson Peter C. , Geddes Colin C. , Traynor Jamie P. , Breuer Judith ,   The COVID-19 Genomics UK (COG-UK) consortium, Thomson Emma C. , Mark Patrick B. 
Published: March 2021

AbstractObjectivesPatients requiring haemodialysis are at increased risk of serious illness with SARS-CoV-2 infection. To improve the understanding of transmission risks in six Scottish renal dialysis units, we utilised the rapid whole-genome sequencing data generated by the COG-UK consortium.MethodsWe combined geographical, temporal and genomic sequence data from the community and hospital to estimate the probability of infection originating from within the dialysis unit, the hospital or the community using Bayesian statistical modelling and compared these results to the details of epidemiological investigations.ResultsOf 671 patients, 60 (8.9%) became infected with SARS-CoV-2, of whom 16 (27%) died. Within-unit and community transmission were both evident and an instance of transmission from the wider hospital setting was also demonstrated.ConclusionsNear-real-time SARS-CoV-2 sequencing data can facilitate tailored infection prevention and control measures, which can be targeted at reducing risk in these settings.
Disparities in Excess Deaths from the COVID-19 Pandemic Among Migrant Workers in Kuwait
Authors: Alahmad Barrak , AlMekhled Dawoud , Odeh Ayah , Gasana Janvier 
Published: March 2021

AbstractBackgroundThe actual human cost of the pandemic cannot be viewed through the COVID-19 mortality rates alone. Especially when the pandemic is widening the existing health disparities among different subpopulations within the same society. In Kuwait, migrant workers were already disproportionately impacted by COVID-19 and its unintended consequences.ObjectiveTo estimate the excess deaths in the pandemic year of 2020 among the Kuwaitis and non-Kuwaiti migrants.MethodsWe analyzed publicly available retrospective data on total annual mortality historically (2005 to 2019) and in 2020. We fitted a quasi-poisson generalized linear model adjusted for yearly trend and nationality to estimate the expected deaths in 2020 in the absence of the pandemic. We calculated excess deaths as the difference between observed and expected mortality for the year of the pandemic in both Kuwaitis and non-Kuwaitis.ResultsIn the absence of the pandemic, we expect the total mortality in Kuwait to be 6629 (95% CI: 6472 to 6789) deaths. However, the observed total mortality in 2020 was 9975 deaths; about 3346 (3186 to 3503) more deaths above the historical trend. Deaths among migrant workers would have been approximately 71.9% (67.8 to 76.0) lower in the absence of the pandemic. On the other hand, deaths among Kuwaitis would have been 32.4% (29.3 to 35.6) lower if the country had not had the pandemic.ConclusionThe mortality burden of the COVID-19 pandemic is substantially higher than what the official tally might suggest. Systematically disadvantaged migrant workers shouldered a larger burden of deaths in the pandemic year. Public health interventions must consider structural and societal determinants that give rise to the health disparities seen among migrant workers.
How financial literacy moderate the association between behaviour biases and investment decision?
Authors: Adil Mohd , Singh Yogita , Ansari Mohd. Shamim 
Published: March 2021

PurposeThe purpose of the study is to examine the impact of behavioural biases (i.e. overconfidence, risk-aversion, herding and disposition) on investment decisions amongst gender. The authors further examine the moderation effect of financial literacy in the relationship between behaviour biases and investment decisions amongst gender.Design/methodology/approachThe study considered a cross-sectional research design. For this survey, the data have been collected through a structured questionnaire from 253 individual investors of the Delhi-NCR region. To analyse the validity and reliability, the Pearson correlation and Cronbach's alpha test have been taken into account respectively. For testing the hypothesis, hierarchical regression analysis has been used in the study.FindingsThe results of the study reveal that amongst male investors, the influence of risk-aversion and herding on investment decision was negative and statistically significant, while the influence of overconfidence on investment decision was positive and significant. However, the influence of disposition was found statistically insignificant. The results stated that amongst female investors the effect of risk-aversion and herding on investment decision was negative and statistically significant. However, the effect of overconfidence and disposition was statistically insignificant influence the investment decision. It has been observed that financial literacy has significantly influenced investment decisions amongst male and female investors. The results of the interaction effect amongst male investors stated that the interaction between overconfidence and investment decision was significantly influenced by financial literacy. However, the interaction of financial literacy with the remaining three biases, i.e. risk-aversion, herding and disposition was found insignificant. The results for the interaction effect of financial literacy with overconfidence, risk-aversion, disposition and herding were found statistically significant amongst female investors.Research limitations/implicationsBased on this present research finding, the study is more productive for the portfolio manager and policymakers at the time of making an investment portfolio for the investors based on their behavioural biases. The study recommends that investors need training programmes, workshops and seminars that enhance financial literacy and financial knowledge of investors which helps them to overcome the behavioural biases while making an investment decision.Originality/valueThe current study aims to explore whether several behavioural biases can affect investment decisions amongst gender. Moreover, the authors would like to examine whether these associations are moderated by financial literacy. In this sense, financial literacy might also show a substantial part in the prediction of investments. The current study might be of the first study that examines the moderation effect financial literacy amongst male and female investors.
Dissatisfaction toward O2O websites: expectation disconfirmation and justice perspective
Authors: Che Tong , Ji Meng , Zheng Xiabing , Feng Bo 
Published: March 2021

PurposeThe online-to-offline (O2O) business is developing rapidly and is highly popular in many countries. Nevertheless, O2O suffers from a large number of customer complaints that result in consumer loss. Focusing on the O2O context, this study integrates expectation disconfirmation theory (EDT) and justice theory to investigate consumers' dissatisfaction toward O2O websites.Design/methodology/approachA research model was proposed and tested using 329 survey responses.FindingsResults show that the identified website disconfirmation and offline service disconfirmation could lead to consumer dissatisfaction. Importantly, the impacts of disconfirmation factors are contingent upon the justice perception of consumers. When a transaction is perceived as unfair, website disconfirmation arouses a higher level of dissatisfaction, and the negative emotions could transfer from O2O and damage the website's reputation.Originality/valueThis study explores the continuance intentions of customers toward O2O websites from a dissatisfaction perspective, with insights for future service studies and O2O service managers.
Stakeholders conflict and private–public partnership chain (PPPC): supply chain of perishable product
Authors: Shareef Mahmud Akhter , Dwivedi Yogesh , Ahmed Jashim Uddin , Kumar Uma , Mahmud Rafeed 
Published: March 2021

PurposeThis paper aims to address procurement, logistics management, inventory control and distribution of perishable items, i.e. vegetables, fruits, flowers and fishes, during the social isolation period of the Covid-19 era to identify conflicting interests among the channel members; present inventory and information sharing scenario; and reveal organizational dispute and existence of redundant, nonessential and corrupted members in the supply chain.Design/methodology/approachThis study uses an exploratory investigation to evaluate the relations among the members of the supply chain of perishable food items. In this context, it is designed to investigate the field, observe the members of the existing supply chain from rural and remote places and capture their interviews to accomplish the objectives.FindingsThis study identified that although the supply chain of perishable food items is controlled truly by private parties, from a realistic view, the private–public partnership is essential where the government should play the coordinating role. In this context, continuous interaction, coordination and information sharing among the members to establish an optimum and scalable network and remove any redundant nodal points is a key success factor for managing an efficient supply chain.Research limitations/implicationsTheoretical and managerial implication of this research is enormous. The existence of functional and dysfunctional conflicts in the same supply network and how it can be detrimental to the performance of the members are exposed in this study, which can be an excellent source to be investigated. Practitioners and researchers can gain a greater understanding to identify the root causes of conflicts in the existing structural dynamics, shedding light on organizational interactions, power and group behavior during the Covid-19 era.Originality/valueFrom the light of management and inter-organizational conflicts, this is a pioneer study that has detected the redundant channel members, their source of power and how their removal can present an optimum channel with group coherence and synergistic interest.
Using complexity and volatility characteristics to guide hybrid project management
Authors: Costantini Silvana , Hall Jon G. , Rapanotti Lucia 
Published: March 2021

PurposeThe paper aims to provide methodological support for hybrid project management, in which the discipline of predictive methodologies combines with the flexibility of adaptive ones. Specifically, the paper explores the extent complexity and volatility dimensions of organisational problems inform choices of PM methodologies both theoretically and in current practice, as a first step towards better methodological support for hybridisation.Design/methodology/approachThe paper takes a mixed method approach, including both secondary research and primary research with practitioners. Primary research consists of a small scale survey (n = 31) followed by semi-structured interviews, with findings triangulated against secondary evidence.FindingsThe paper provides empirical insights on how complexity and volatility of organisational problems can inform hybrid project management practices. Specifically, it suggests a mapping between volatility and complexity dimensions and predictive and adaptive risk controls as a first step towards the systematisation of hybrid combinations in projects.Research limitations/implicationsDue to the small participant sample, the research results may lack generalisability.Practical implicationsThe paper includes implications for the development of methodological support for setting up hybrid projects in practice.Originality/valueThe paper addresses a gap acknowledged both in the literature and by practitioners.