bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Value of Preoperative Neutrophil-to -Lymphocyte Ratio in Adenoid Cystic Carcinoma of the Head and Neck
Authors: LI XIN-RAN , ZHOU LIN , CHEN YU-XIN , LI NA , MENG JIAN 
Published: November 2021

Abstract
BackgroundStudies in recent years have shown that the neutrophil-to-lymphocyte ratio (NLR) is associated with the survival and prognosis of patients with malignant tumors.However, the utility of the NLR in predicting outcomes in patients with adenoid cystic carcinoma (ACC) of the head and neck remains unclear. Here, we examined the prognostic value of the preoperative NLR in patients with ACC of the head and neck.MethodsThis study retrospectively analyzed 71 patients with a histopathological diagnosis of ACC from August 2005 to November 2020.The optimal cutoff value was obtained by receiver operating characteristic (ROC) analysis. The characteristics of the patients were evaluated using chi-squared tests.The value of the NLR used in predicting the outcomes of these patients was analyzed using Kaplan-Meier curves and Cox regression models.ResultsThe cutoff value of the NLR was 2.071. The chi-squared tests showed that a high NLR(>2.071)was associated with tumor stage and lymph node metastasis(LNM). Kaplan-Meier survival analysis showed that the NLR>2.071 group was correlated with a shorter Overall survival(P<0.05). In multivariate Cox regression analysis, high NLR (>2.071) and high age (>54 years) were independent risk factors predicting poorer outcomes in patients with ACC.ConclusionsWe suggest that the preoperative NLR is a useful biomarker for the prognosis of patients with ACC.
Orientation-dependent Fiber-optic Inclinometer Based on Core-offset Michelson Interferometer
Authors: WANG Hua-jie , ZHENG Lai-fang , ZHANG Jun-sheng 
Published: November 2021

Abstract
An in-fiber Michelson interferometer (MI) inclinometer, which consists of misalignment-spliced fiber with end coating, is proposed and experimentally demonstrated. The incident light divided at the misalignment-spliced joint is reflected at the end coating, and then re-coupled into the core of the fiber. Due to the phase difference between the core mode and the cladding mode, a typical Michelson interference is obtained. The fiber near the misalignment-spliced joint is inserted in two capillary quartz tubes. The inclination of the capillary quartz tube leads to a significant deformation and curvature of the misalignment-spliced joint, which causes the wavelength and amplitude of the MI spectrum to change. The experimental results indicate a good response within the angle range of 0º to 50º. Both the wavelength modulation and intensity modulation are realized, with sensitivities of 0.55 nm/deg and 0.17 dB/deg, respectively. Moreover, the sensor shows a strong orientation dependence due to the asymmetric structure in the misalignment-spliced joint.
Halomonas jincaotanensis sp. nov., a 1-naphthylamine degrading bacterium isolated from Pamir Plateau
Authors: Bu Xuying , Xia Zhanfneg , Liu Zhanwen , Ren Min , Wan Chuanxing , Zhang Lili 
Published: November 2021

Abstract
A Gram-staining-negative, aerobic, rod-shaped bacterium, designated strain TRM 85114 T , was isolated from Jincaotan wetland in Pamir Plateau, PR China. According to the study, we found it have an ability to degrade 1-naphthylamine. Strain TRM 85114 T grow at 4-35 ℃ (optimum, 30 ℃), pH of 6.0-9.0 (optimum, pH 6.0) and can tolerate 1%-10% (w/v) NaCl (optimum, 3%). Phylogenetic analysis of 16S rRNA gene sequences revealed that strain TRM 85114 T was affiliated of the genus Halomonas , sharing high sequence similarity (97.3%) with the type strain of Halomonas korlensis XK1 T . The primary cellular fatty acids of strain TRM 85114 T were C 16:0 and C 19:0 cyclo ω 8 c . The predominate respiratory quinone was Q-9. The polar lipids were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, lyso-phospatidylglycerol, phospholipids of unknown structure containing glucosarmine, and five unidentified lipids. The genomic DNA G+C content of strain TRM 85114 T was 61.6 mol%. Calculated the average nucleotide identities and the digital DNA-DNA hybridization values between strain TRM 85114 T and the related type Halomonas strains further revealed that TRM 85114 T represented a novel species of the genus Halomonas , for which the name Halomonas jincaotanensis sp. nov. is proposed. The type strain is TRM 85114 T (CCTCC AB 2021006 T =LMG 32311 T ).
The Role of Industrial Parks Entrepreneurial Ecosystem in Strengthening Ventures' Capability: Evidence From Ethiopian Small Manufacturing Enterprises
Authors: Hailu Tesfayé , Chebo Abdella Kosa Kosa 
Published: November 2021

Abstract
Small scale enterprises sector has been recognized as an integral component of economic development and it is advisable and indispensable to integrate the enterprises with Industrial parks for sustainable business operation. IPs plays a crucial role in organizing the resources and innovation of manufacturing operation through business advising, infrastructure provision, technology transfer, and R&D support which advances firms’ capability. In this sense, the objective of this was to investigate the role IPs entrepreneurial ecosystem towards improving the capability of small ventures. Data were obtained from a sample of 245 small manufacturing enterprise owners selected through simple random sampling and analysed using descriptive, multi-level regression analysis and OLS regression analysis. From this, the presence of better and suitable entrepreneurial ecosystem which consists of provision of training, market information, adequate finance, and government commitment positively contributes for improvement of small firm’s capability. Despite of this, the study also found that there are many barriers hindered the development of strong entrepreneurial ecosystem in Ethiopia, such as, human capital, institutional, financial, market, policies and legal procedures, cultural and resource barriers. The entrepreneurial ecosystem influences the resources capability more when academia-industry linkage exists. The OLS regression result also shows that the entrepreneurial skill mediates the influence of entrepreneurial ecosystem on technological capability, while managerial knowledge mediates the influence of entrepreneurial ecosystem on the firm’s resource capability. The implication for policymakers is to develop a policy that supports incorporating small firms in industrial parks entrepreneurial ecosystem and link with academia. The study also forwarded a clue for managers of small firms in improving their firms technological and resource capabilities through building managerial knowledge and entrepreneurial skills.
Nursing Interventions For Prevention of Corneal Injury: A Protocol For A Systematic Review
Authors: Prado Patrícia Rezende do , Silveira Renata Cristina Campos Pereira , Vettore Mario Vianna , Fossum Mariann , Vabo Grete Lund , Gimenes Fernanda Raphael Escobar 
Published: November 2021

Abstract
Background: Critically ill patients are vulnerable to corneal injury and the incidence of this adverse event remains high in these patients. Randomized clinical trials have been assessing different types of interventions, hindering nurses' clinical practice for the prevention of corneal injury in critically ill patients. The aim of this systematic review is to identify the most effective nursing interventions to prevent corneal injury in critically ill sedated and mechanically ventilated patients.Methods: A systematic review of intervention studies will be conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses 2020, in the following electronic databases: Cumulative Index to Nursing and Allied Health Literature, Cochrane Central, Embase, Latin American and Caribbean Literature in Health Sciences, Livivo, PubMed, Scopus and Web of Science. The search of the grey literature will be undertaken on Google Scholar. No language or year of publication restrictions will be applied for the selection of primary studies. Study selection and data extraction will be performed by two independent reviewers who will screen the titles and abstracts of the retrieved papers to assess the studies for inclusion. Disagreements between reviewers, during study selection, will be resolved by discussion with a third reviewer. The inclusion criteria will be epidemiologic intervention studies evaluating nursing interventions to prevent or decrease the occurrence of corneal injury in critically ill sedated and mechanically ventilated patients. Methodological quality of the studies will be assessed using the Risk of Bias and Robins-2 tools. Quality of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation system. Discussion: this study has a potencial to identify the most effective nursing interventions for prevention corneal injury in critically ill sedated and mechanically ventilated patients.Systematic review registration: The protocol of this research is approved in PROSPERO under protocol No. 253289.
Potential Biomarkers for Predicting the Overall Survival of Kidney Renal Papillary Cell Carcinoma: A Analysis of N6-Methylandenosine-Related lncRNAs
Authors: Wu zixuan , Huang Xuyan , Cai Min-jie , Huang Peidong 
Published: November 2021

Abstract
Background: It is well established that disease-free survival and overall survival after breast conservation surgery (BCS) followed by radiotherapy are equivalent to that after mastectomy. However, in Asian countries, the rate of BCS continues to remain low. The cause may be multifactorial including the patient’s choice, availability and accessibility of infrastructure and surgeon’s choice. We aimed to elucidate the Indian surgeons’ perspective while choosing between BCS and mastectomy, in women oncologically eligible for BCS. Methods: We conducted a survey-based cross-sectional study over 3 weeks between January-February 2021. Indian surgeons with general surgical or specialised onco-surgical training, who consented to participate were included in the study. Multinomial logistic regression was performed to assess the effect of study variables on offering mastectomy or BCS to an eligible patient.Results: A total of 347 responses were included. The mean age of the participants was 43(11) years. 63% of the surgeons were in the 25-44 years age group with the majority (80%) being males. 66.4% of surgeons ‘almost always’ offered BCS to oncologically eligible patients. Surgeons who had undergone specialised training in oncosurgery or breast conservation surgery were 35 times more likely to offer BCS (p<0.01). Surgeons working in hospitals with in-house radiation oncology facilities were 9 times more likely to offer BCS (p<0.05). Surgeons’ years of practice, age, sex and hospital setting did not influence the surgery offered.Conclusion: Our study found that two-thirds of Indian surgeons preferred BCS over mastectomy. Lack of radiotherapy facilities and specialised surgical training were deterrents to offering BCS to eligible women.
Lung-targeted Macrophage Biomimetic Nanocarriers Based on Platycodon Grandiflorum Polysaccharides for Calming Cytokine Storm in Pneumonia
Authors: Li Yi , Guo Chunjing , Chen Qiang , Su Yanguo , Guo Huimin , Chen Daquan 
Published: November 2021

Abstract
Background

Pneumonia is a life-threatening respiratory disease without effective treatment due to uncontrolled inflammation of the lung tissue. Suppression of cytokine storms may be one of the keys to saving the lives of patients with severe pneumonia. Given the fragile delivery efficiency of drugs in vivo, novel delivery platforms to address these issues are necessary.
Results

Here, we developed a biomimetic nanocarrier (MNPs) with macrophage membranes coated ROS-responsive Platycodon grandiflorum polysaccharides nanoparticles (PNPs) for targeted delivery of curcumin (MNPs@Cur) to inflamed lungs and treat inflammation by calming cytokine storms. In the study, we could clearly find that MNPs@Cur significantly attenuated inflammation and cytokine storm syndrome in acute lung injury (ALI) mice by neutralizing multiple proinfammatory cytokines. Interestingly, we found that the PNPs also had potent pulmonary targeting compared to other polysaccharide carriers, which probably means that PNPs have inherited the natural targeting ability in the medicinal guide theory of Traditional Chinese Medicine (TCM).
Conclusion

The results demonstrated that the developed drug delivery system may serve as an effective and safe nanoplatform for the treatment of pneumonia, as well as provide experimental scientific basis for the medicinal guide theory of TCM and its clinical application.
Quantitative Measurements for Factors Influencing Implementation In School Settings: Protocol for A Systematic Review and A Psychometric and Pragmatic Analysis
Authors: Hoy Sara , Helgadóttir Björg , Norman Åsa 
Published: November 2021

Abstract
Background: To address the effectiveness and sustainability of school-based interventions, there is a need to consider factors affecting implementation success. This rapidly growing field of implementation focused research is struggling with how to assess and measure implementation-relevant constructs. Earlier research identifies the need for strong psychometric and pragmatic measures. The aims of this review are therefore to (i) systematically review the literature to identify measurements of factors influencing implementation which have been developed or adapted in school settings, (ii) describe each measurement’s psychometric and pragmatic properties, (iii) describe the alignment between each measurement and corresponding domain and/or construct of the Consolidated Framework for Implementation Research (CFIR).Methods: Six databases (Medline, ERIC, PsycInfo, Cinahl, Embase, and Web of Science) will be searched for peer-reviewed articles reporting on primary and secondary school settings, published from year 2000. Our search string will be built on three core levels of terms for: (a) implementation, (b) measurement, and (c) school settings. Two independent researchers will screen articles and extract data, with a third researcher cross-checking the process. The identified measurements will be mapped against CFIR domains and constructs, and analyzed for their psychometric and pragmatic properties using The Psychometric and Pragmatic Evidence Rating Scale (PAPERS), as well as for their measurement equivalence (invariance). The protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P).Discussion: By identifying measurements that are psychometrically and pragmatically strong in the field, this review can contribute to the identification of feasible, effective, and sustainable implementations strategies. Through highlighting the gaps within the range of constructs in the tools retrieved, this review may provide insights for future research and where resources could be allocated. Combined, this review will provide a greater understanding of factors influencing implementation of initiatives within school settings, and how these can be further studied.Registration: This review is submitted to be prospectively registered on PROSPERO ID: 284741. Submission occurred the 12th of October 2021.
Preoperative Small Pulmonary Nodule Localisation Using Hookwires or Coils: Strategy Selection in Adverse Events
Authors: Zuo Tao , Gao Zhaoming , Wen Bing , Chen Baojun , Zhang Zhenfa 
Published: November 2021

Abstract
Objective
We conducted a retrospective study of adverse events associated with the preoperative procedure of computed tomography (CT)–guided hookwire or coil localisation. We analysed the experience of and process flaws in resecting ground-glass nodules (GGNs) using video-assisted thoracoscopic surgery (VATS) and determined the remedial strategy.
Methods
Adverse events were evaluated in 20 patients with 25 GGNs who underwent CT-guided hookwire or coil localisation before VATS. For lesions not successfully marked or detected, palpation, resection of the highly suspected area, segmentectomy or lobectomy was performed.
Results
Among all adverse events, 10 were dislodgement of the marking materials, 2 were breakaway of the marking materials, 4 were >2-cm distance between the lesions and the tip, one was marking material across the two adjacent lobes, 10 were pneumothorax and two were certain parts of marking materials stuck into the walls. All GGNs were resected successfully. Fifteen lesions were detected by palpation. Three GGNs were discovered after the resection of highly suspected areas. The GGNs were removed by lobectomy. Segmentectomies and lobectomies were performed directly on two and four GGNs, respectively.
Conclusions
When adverse events occur, a second localisation, intraoperative localisation, resection of a highly suspected area, or a segmentectomy or lobectomy can be successfully attempted using VATS for resection of GGNs.
Risk factors analysis and establishment of a clinical predictive model for recurrence after first attack of myasthenia gravis: a single-center retrospective study
Authors: Liu Jiayi , Liu Lulu , Zhang Zhengxiang 
Published: November 2021

Abstract
Background Myasthenia gravis (MG) is a rare and recurrent disease. The purpose of this study was to investigate the risk factors for relapse in MG patients after their first attack and establish a clinical predictive model. We conducted a retrospective study of 86 MG patients, followed and reviewed the clinical data of patients from the first onset to the first relapse, including age of onset, site of first symptom, MGFA at onset, thymoma, surgical resection of the thymoma, infection history, irregular drug use, combination of other autoimmune diseases, AChR antibody, and anti-Musk antibody, etc. The R software was used for statistical analysis. Univariate analysis and multivariate analysis were used to analyze risk factors. The clinical predictive model was established by Logistic regression analysis. Results Within 2 years after the first attack, 61.2% of MG patients relapsed. MGFA at onset, irregular drug use and infection history were independent risk factors for MG relapse within 2 years after the first attack ( p < 0.05). The clinical prediction model has good discrimination and calibration. Conclusion The relapse of MG is affected by a variety of factors. The clinical predictive model that was established in this study can help clinicians predict the probability of relapse in MG patients, identify early high-risk relapse patients, and serve for high-quality clinical management.
Clinical Characteristics of Bacterial Spectrum and Antimicrobial Resistance in Urine and Stone Cultures From Patients With Kidney Stone Disease
Authors: Lei Min , Jiang Zheng , Xu Peng , An Lingyue , Chang Zhenglin , Zhang Yuyan , Zhang Shike , Zeng Tao , Li Shujue , Tiselius Hans-Göran , Zeng Guohua , Wu Wenqi 
Published: November 2021

Abstract
Background

It is important to understand the clinical characteristics of bacterial spectrum and antibiotic resistance of urine and stone pathogens for the prevention and treatment of urolithiasis and perioperative infection.
Methods

Consecutive patients with kidney stones treated by percutaneous nephrolithotomy (PCNL) from September 2016 to September 2018 were included. The bacterial species and antibiotic sensitivity test of the germs cultured from clean middle-stream urine and from stones intraoperatively were evaluated.
Results

In 1055 patients, the rate of positive bacterial test was higher in stones than in urine (337, 31.0% vs. 221, 20.9%, p=0.016). 167(15.8%) patients had both positive urine culture (UC) and stone culture (SC), of which 137 (82.0%) had identical bacteria in both cultures. In infection stone patients, the positive rate of bacteria was 34.7% (91/262) in urine and 52.3% (137/262) in stone, and in non-infection stone patients, was 16.4% (130/793) and 25.2% (200/793). The positive rate of SC in patients with different types of stones were higher than that of UC. E. coli was the most common organism not only in both UC (54.3% ,120/221) and SC (43.9%,148/337) but also in urine and stones from patients with infection stones (44.0%,32.8%) or non-infection stones (61.5%,51.8%). Furthermore, the pathogens isolated from urine and stones showed high resistance to fluoroquinolones, ceftriaxone, cefazolin, cefuroxime, β-lactamases and sulfonamides (all resistance>20%).
Conclusions

The bacterial spectra demonstrated in stones and urine samples were significantly different. Positive SC was more commonly encountered than positive UC. Compared with non-infection stones, infection stones were accompanied by higher rates of positive tests in both cultures. The antibiotic resistance was comparable between bacteria in the two cultures. A combination of antibiotic sensitivity results in urine and stones might be a useful guide for selection of effective and appropriate treatment aiming at reduced problems with bacterial antibiotic resistance.
Association Between Serum 5-methyltetrahydrofolate and Homocysteine in Chinese Hypertensive Participants With Different MTHFR C677T Polymorphisms: A Cross-sectional Study
Authors: Cheng Yu , Liu Shuai , Chen Duo , Yang Yiman , Liang Qiongyue , Huo Ya , Zhou Ziyi , Zhang Nan , Wang Zhuo , Liu Lishun , Song Yun , Liu Xiangyi , Duan Yong , Liang Xiuwen , Hou Bingjie , Wang Binyan , Tang Genfu , Qin Xianhui , Yan Fangrong 
Published: November 2021

Abstract
Background and aims: Clarifying the association between 5-methyltetrahydrofolate and homocysteine and the effect pattern of methylene tetrahydrofolate reductase (MTHFR C677T) may contribute to the management of homocysteine and may serve as a significant reference for a randomized controlled trial of 5-methyltetrahydrofolate intervention. This study aimed to reveal the association between these two biochemical indices. Methods: Study population was drawn from the baseline data of the China Stroke Primary Prevention Trial (CSPPT), including 2,328 hypertensive participants. 5-methyltetrahydrofolate and homocysteine were determined by stable-isotope dilution liquid chromatography-tandem mass spectrometry and automatic clinical analyzers, respectively. MTHFR C677T polymorphisms were detected using TaqMan assay. Multiple linear regression was performed to evaluate the association between serum 5-methyltetrahydrofolate and homocysteine. Results: There was a significant inverse association between 5-methyltetrahydrofolate and homocysteine when 5-methyltetrahydrofolate was B 10 ng/mL, and this association was modified by MTHFR C677T (per 1-ng/mL increment; All: a = -0.50, P < 0.001; CC: c = -0.14, P = 0.087; CT: k = -0.20, P = 0.011; TT: g = -1.19, P < 0.001). Moreover, the decline in trend in genotype TT participants was stronger than in genotype CC participants (P for difference < 0.001) and genotype CT participants (P for difference < 0.001), while there was no significant difference between genotype CC and genotype CT participants (P for difference = 0.757). Conclusions: Our data showed a non-linear association between serum homocysteine and 5-methyltetrahydrofolate among Chinese hypertensive adults, however, it could be inversely linearly fitted when serum 5-methyltetrahydrofolate was r 10 ng/mL , and this association was modified by MTHFR C677T.