bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan K-Medoids Clustering Pada Ekspor Buah-Buahan Menurut Negara Tujuan
Authors: Saputri Aris , Hidayatullah Hidayatullah , Dermawan Ari 
Published: February 2021

Abstrack:The aim of the study is to group fruit exports according to the country of destination. The research data used came from the Indonesian Central Statistics Agency with the url https://www.bps.go.id/ for the category of fruit exports by destination country. The computer science technique used is to utilize K-Medoids clustering data lamination. The results of the study are expected to provide information to the government about the mapping results in the form of clusters of the destination countries for the number of fruit exports. This needs to be done to review the process of fruit exports to destination countries, bearing in mind the results of the export of these fruits have the potential to improve the Indonesian economy. Keywords:Data mining, Klastering, K-Medoids, Fruit Export, Destination Country. Abstrak:Tujuan dari penelitian adalah untuk mengelompok kan ekspor buah-buahan menurut negara tujuan. Data penelitian yang digunakan berasal dari Badan Pusat Statistik Indonesia dengan kategori ekspor buah-buahan menurut negara tujuan. Teknik ilmu komputer yang digunakan adalah dengan memanfaat kan data mining klastering K-Medoids. Hasil penelitian diharapkan dapat memberikan informasi kepada pemerintah tentang hasil pemetaan berupa cluster terhadap Negara tujuan untuk jumlah ekspor buah-buahan. Hal ini perlu dilakukan untuk meninjau ulang proses ekspor buah buah kenegara tujuan mengingat hasil ekspor buah-buah tersebut berpotensi untuk meningkatkan perekonomian Indonesia. Kata Kunci:Data mining, Klastering, K-Medoids, Ekspor Buah, Negara Tujuan
Integrative Analysis of Proteomics and DNA Methylation in Orbital Fibroblasts From Graves’ Ophthalmopathy
Authors: Virakul Sita , Somparn Poorichaya , Pisitkun Trairak , van der Spek Peter J. , Dalm Virgil A. S. H. , Paridaens Dion , van Hagen P. Martin , Hirankarn Nattiya , Palaga Tanapat , Dik Willem A. 
Published: February 2021

BackgroundGraves’ ophthalmopathy (GO) is a frequent extrathyroidal complication of Graves’ hyperthyroidism. Orbital fibroblasts contribute to both orbital tissue inflammation and remodeling in GO, and as such are crucial cellular elements in active GO and inactive GO. However, so far it is largely unknown whether GO disease progression is associated with functional reprogramming of the orbital fibroblast effector function. Therefore, the aim of this study was to compare both the proteome and global DNA methylation patterns between orbital fibroblasts isolated from active GO, inactive GO and healthy controls.MethodsOrbital fibroblasts from inactive GO (n=5), active GO (n=4) and controls (n=5) were cultured and total protein and DNA was isolated. Labelled and fractionated proteins were analyzed with a liquid chromatography tandem-mass spectrometer (LC-MS/MS). Data are available via ProteomeXchange with identifier PXD022257. Furthermore, bisulphite-treated DNA was analyzed for methylation pattern with the Illumina Infinium Human Methylation 450K beadchip. In addition, RNA was isolated from the orbital fibroblasts for real-time quantitative (RQ)-PCR. Network and pathway analyses were performed.ResultsOrbital fibroblasts from active GO displayed overexpression of proteins that are typically involved in inflammation, cellular proliferation, hyaluronan synthesis and adipogenesis, while various proteins associated with extracellular matrix (ECM) biology and fibrotic disease, were typically overexpressed in orbital fibroblasts from inactive GO. Moreover, orbital fibroblasts from active GO displayed hypermethylation of genes that linked to inflammation and hypomethylated genes that linked to adipogenesis and autoimmunity. Further analysis revealed networks that contained molecules to which both hypermethylated and hypomethylated genes were linked, including NF-κB, ERK1/2, Alp, RNA polymerase II, Akt and IFNα. In addition, NF-κB, Akt and IFNα were also identified in networks that were derived from the differentially expressed proteins. Generally, poor correlation between protein expression, DNA methylation and mRNA expression was observed.ConclusionsBoth the proteomics and DNA methylation data support that orbital fibroblasts from active GO are involved in inflammation, adipogenesis, and glycosaminoglycan production, while orbital fibroblasts from inactive disease are more skewed towards an active role in extracellular matrix remodeling. This switch in orbital fibroblast effector function may have therapeutic implications and further studies into the underlying mechanism are thus warranted.
Identification of LncRNA Prognostic Markers for Ovarian Cancer by Integration of Co-expression and CeRNA Network
Authors: Liang Huisheng , Bai Yuquan , Wang Hailong , Yang Xiangjun 
Published: February 2021

BackgroundOvarian cancer (OC), one of the most prevalent gynecological malignancies, is characterized by late detection and dismal prognosis. Recent studies show that long non-coding RNAs (lncRNAs) in competitive endogenous RNA (ceRNA) networks influence immune infiltration and cancer prognosis. However, the function of lncRNA in OC immune infiltration and prognosis remains unclear.MethodsTranscriptomes of 378 OC samples and clinical data were retrieved from the TCGA repository. Modules related to immune cells were identified using weighted gene co-expression network analysis (WGCNA). Functional enrichment analysis and survival analysis were then performed for the identification of immune-related lncRNAs in the brown module using Cox regression model. Finally, a ceRNA network was constructed by using the lncRNAs and mRNAs from the brown module.ResultsWe found lncRNAs and mRNAs in the brown module to be significantly associated with immune cells in OC and identified 4 lncRNAs as potential OC prognostic markers. We further established that lncRNAs in the ceRNA network influence OC immune infiltration and prognosis by regulating miRNA, ultimately modulating mRNA levels.ConclusionWe have identified 4 lncRNAs as independent immune prognostic factors for OC. Furthermore, our findings offer novel insight into lncRNAs as OC immune and prognostic biomarkers.
Risk Assessment by Pre-surgical Tractography in Left Hemisphere Low-Grade Gliomas
Authors: Ius Tamara , Somma Teresa , Baiano Cinzia , Guarracino Ilaria , Pauletto Giada , Nilo Annacarmen , Maieron Marta , Palese Francesca , Skrap Miran , Tomasino Barbara 
Published: February 2021

Background: Tracking the white matter principal tracts is routinely typically included during the pre-surgery planning examinations and has revealed to limit functional resection of low-grade gliomas (LGGs) in eloquent areas.Objective: We examined the integrity of the Superior Longitudinal Fasciculus (SLF) and Inferior Fronto-Occipital Fasciculus (IFOF), both known to be part of the language-related network in patients with LGGs involving the temporo-insular cortex. In a comparative approach, we contrasted the main quantitative fiber tracking values in the tumoral (T) and healthy (H) hemispheres to test whether or not this ratio could discriminate amongst patients with different post-operative outcomes.Methods: Twenty-six patients with LGGs were included. We obtained quantitative fiber tracking values in the tumoral and healthy hemispheres and calculated the ratio (HIFOF–TIFOF)/HIFOF and the ratio (HSLF–TSLF)/HSLF on the number of streamlines. We analyzed how these values varied between patients with and without post-operative neurological outcomes and between patients with different post-operative Engel classes.Results: The ratio for both IFOF and SLF significantly differed between patient with and without post-operative neurological language deficits. No associations were found between white matter structural changes and post-operative seizure outcomes.Conclusions: Calculating the ratio on the number of streamlines and fractional anisotropy between the tumoral and the healthy hemispheres resulted to be a useful approach, which can prove to be useful during the pre-operative planning examination, as it gives a glimpse on the potential clinical outcomes in patients with LGGs involving the left temporo-insular cortex.
An Integrative Pharmacology-Based Pattern to Uncover the Pharmacological Mechanism of Ginsenoside H Dripping Pills in the Treatment of Depression
Authors: Zhao Libin , Guo Rui , Cao Ningning , Lin Yingxian , Yang Wenjing , Pei Shuai , Ma Xiaowei , Zhang Yu , Li Yingpeng , Song Zhaohui , Du Wuxun , Xiao Xuefeng , Liu Changxiao 
Published: February 2021

Objectives: To evaluate the pharmacodynamical effects and pharmacological mechanism of Ginsenoside H dripping pills (GH) in chronic unpredictable mild stress (CUMS) model rats.Methods: First, the CUMS-induced rat model was established to assess the anti-depressant effects of GH (28, 56, and 112 mg/kg) by the changes of the behavioral indexes (sucrose preference, crossing score, rearing score) and biochemical indexes (serotonin, dopamine, norepinephrine) in Hippocampus. Then, the components of GH were identified by ultra-performance liquid chromatography-iron trap-time of flight-mass spectrometry (UPLC/IT-TOF MS). After network pharmacology analysis, the active ingredients of GH were further screened out based on OB and DL, and the PPI network of putative targets of active ingredients of GH and depression candidate targets was established based on STRING database. The PPI network was analyzed topologically to obtain key targets, so as to predict the potential pharmacological mechanism of GH acting on depression. Finally, some major target proteins involved in the predictive signaling pathway were validated experimentally.Results: The establishment of CUMS depression model was successful and GH has antidepressant effects, and the middle dose of GH (56 mg/kg) showed the best inhibitory effects on rats with depressant-like behavior induced by CUMS. Twenty-eight chemical components of GH were identified by UPLC/IT-TOF MS. Subsequently, 20(S)-ginsenoside Rh2 was selected as active ingredient and the PPI network of the 43 putative targets of 20(S)-ginsenoside Rh2 containing in GH and the 230 depression candidate targets, was established based on STRING database, and 47 major targets were extracted. Further network pharmacological analysis indicated that the cAMP signaling pathway may be potential pharmacological mechanism regulated by GH acting on depression. Among the cAMP signaling pathway, the major target proteins, namely, cAMP, PKA, CREB, p-CREB, BDNF, were used to verify in the CUMS model rats. The results showed that GH could activate the cAMP-PKA-CREB-BDNF signaling pathway to exert antidepressant effects.Conclusions: An integrative pharmacology-based pattern was used to uncover that GH could increase the contents of DA, NE and 5-HT, activate cAMP-PKA-CREB-BDNF signaling pathway exert antidepressant effects.
Opera-Based Instrumental Parodies in Antonio Vivaldi's Concertos
Authors: Пастушкова Анна Сергеевна 
Published: February 2021

В статье рассмотрена проблема композиционных параллелизмов между инструментальными концертами и оперными ариями Антонио Вивальди. Введены термины для описания типов «театрализованной» ритурнельной формы и композиционного устройства концертов. Показано влияние признаков оперной арии на форму и жанровую специфику частей инструментального концерта. Предложена новая классификация примеров протяженного цитирования оперных арий в инструментальных концертах, среди которых - неизвестные ранее цитаты, обнаруженные автором статьи в концертах RV 139, RV 159 и RV 189.
The article deals with thematic concordances between instrumental concertos and operatic arias by Antonio Vivaldi. New terms are proposed in order to describe the types of ‘operatic' ritornello form and sections of musical compositions. Comparative analysis of the music material of arias and corresponding concertos shows the influence of operatic aria's features to musical form and genre of concerto's movements. Based on various types of such influence, new classification of all presently known cases of the operatic arias reworked by Vivaldi for his instrumental concertos and vice versa is delivered. Proposed classification includes previously unknown cases of self-borrowing discovered by the author of this article in the instrumental concertos RV 139, RV 159 and RV 189.
Dargomyzhsky's Esthetics: Traditional Approach with Nontraditional Conclusions
Authors: Степанова Ирина Владимировна 
Published: February 2021

В статье рассматривается эстетика Даргомыжского. В течение двух десятилетий автор читает в Московской консерватории спецкурс, посвященный этому русскому классику. Детальное изучение эпистолярия композитора и редко исполняемых сочинений вызвало желание пересмотреть многие хрестоматийные положения, касающиеся его эстетики и общей эволюции творчества. Хочется верить, что знакомство с предлагаемым текстом подарит читателю не только ощущение новизны восприятия музыки Даргомыжского, но и приблизит к пониманию истинной сложности его личности, которая оказывается значительно более яркой, глубокой и интригующей, чем представлялась ранее. Пафос статьи не ограничивается сказанным. Одна из центральных проблем, в ней поднятых, связана со степенью одаренности композитора. Она активно обсуждалась при жизни Даргомыжского, замалчивалась в советское время, возвысившее композитора до великих по идеологическим причинам, но сегодня вновь актуальна. Автор не скрывает полемической заостренности этого вопроса.
The article deals with the esthetics of Dargomyzhsky. For two decades the author has been delivering a specialized course dedicated to this Russian classic. Detailed examination of the composer's epistolary and the seldom performed pieces inspired the desire to revise many of the canonical concepts pertaining to his esthetics and the general evolution of his oeuvre. Tantalizingly, the glimpse of this narrative will not only compliment the reader with a feeling of new perception of Dargomyzhsky's music but will also bring us closer to understanding of the intrinsic sophistication of his personality that turns out to be much brighter, deeper and thought-provoking than it previously appeared. The message of the article is not confined to the above said. One of its focal points is related with the extent of the composer's natural aptitude. This topic was actively discussed during Dargomyzhsky's life, hushed up about in the Soviet times when Dargomyzhsky was raised to the “great” level for ideological reasons, but today has again resumed its actuality. The author does not hold back the polemic bitterness of this issue.
Vasily Sapelnikov vs Imperial Russian Musical Society (1903): New Materials
Authors: Шабшаевич Елена Марковна 
Published: February 2021

В статье рассматривается история конфликта выдающегося пианиста Василия Львовича Сапельникова с руководством Императорского Русского музыкального общества (в лице глав Петербургской и Московской дирекций - Цезаря Антоновича Кюи и Василия Ильича Сафонова) в 1903 году. Инцидент был вызван нарушением договоренности о неучастии Сапельникова в концертах Московского филармонического общества в случае заключения контракта с ИРМО. Посредником в переговорах стало немецкое концертное агентство Вольфа, которое устраивало данный ангажемент. Подробный анализ сложившейся ситуации стал возможен благодаря привлечению новых архивных источников из фондов Российского национального музея музыки - переписки непосредственных участников инцидента, которая впервые вводится в научный оборот. Ее анализ в комплексе с сопутствующими уже опубликованными материалами не только проясняет конкретные обстоятельства дела, но и позволяет воссоздать контекст концертной жизни русских столиц начала XX века - в частности, особенности менеджмента в условиях конкуренции филармонических организаций, институциональное положение артиста, степень юридического оформления его прав и обязанностей.
The article deals with the history of the conflict between the outstanding pianist Vasily L. Sapelnikov and the Directorate of the Imperial Russian Musical Society (represented by the Heads of St. Petersburg and Moscow Divisions-Cesar A. Cui and Vasily I. Safonov) in 1903. The incident was caused by Sapelnikov's breach of condition of his non-participation in concerts of Moscow Philharmonic Society in case of signing a contract with Imperial Russian Musical Society. Wolff's Concert Agency, which arranged this engagement, became the mediator in the negotiations. A detailed analysis of the case was made possible by attracting new archival sources from the collections of the Russian National Museum of Music, i. e. the correspondence of participants of the incident, which is being introduced into scientific circulation for the first time. Its study and analysis, together with the accompanying published materials, not only clarify the specific circumstances of the case, but also allow us to reconstruct the context of the concert life of Russian capitals in the early 20 century-in particular, the features of management in the conditions of competing Philharmonic organizations, the institutional position of the artist, the degree of legal registration of his rights and duties.
“Dodekachordon” by Heinrich Glareanus and “Dodecacorde” by Claude Le Jeune: An Experience of Comparison
Authors: Лыжов Григорий Иванович 
Published: February 2021

В статье демонстрируется редкий исторический пример такой связи музыкальной теории и композиторской практики, при котором художественный текст возникает отчасти как воплощение идей текста музыкально-научного. Особенной выглядит подчеркивающая эту связь идентичность названия трактата Генриха Глареана («Dodekachordon», 1547) и обширного цикла полифонических псалмовых композиций Клоде Лежёна («Dodecacorde», 1598). Однако различия превышают сходство: помимо того, что 12-ладовая система Глареана воспринята Лежёном через призму трактатов Джозеффо Царлино, его цикл глубоко отличается от своего музыкально-теоретического «однофамильца» и мировоззренчески, и стилистически. В то же время композиционные решения Лежёна зачастую представляют собой лишь радикальные выводы из тех гуманистических предпосылок, которые были внесены в теорию лада Глареаном и развиты Царлино.
The article demonstrates a rare historical example of such a connection between musical theory and composer's practice, in which a musical text arises partly as an embodiment of the ideas of a musical-scientific text. This connection is emphasized by the identity of titles of the treatise by Heinrich Glarean (“Dodekachordon,” 1547) and of the extensive cycle of polyphonic psalm compositions by Claude Le Jeune (“Dodecacorde,” 1598). However, the differences exceed the similarities: in addition to the fact that Glarean's system of 12 modes was perceived by Le Jeune through the prism of Gioseffo Zarlino's treatises, his cycle is deeply different from his musical-theoretical “namesake” both philosophically and stylistically. At the same time, Le Jeune's compositional solutions often represent radical conclusions from those humanistic assumptions that were introduced into the modal theory by Glarean and developed by Zarlino.
About the New Opera by Alexander Tchaikovsky: To the Interpretation of the Genre
Authors: Григорьева Галина Владимировна 
Published: February 2021

Статья посвящена анализу новой оперы А. Чайковского «Сказ о Борисе и Глебе» - исследованию особенностей драматургии и музыкального языка, а также ее сценической интерпретации. Оправданность режиссерского решения с опорой на пластику обусловлена оригинальной композиторской трактовкой жанра с уклоном в сторону оратории и инструментального концерта, с активным противопоставлением речи и музыки, сочетанием монументальности и динамичности, академической серьезности и демократической открытости.
The article is devoted to the analysis of the new opera by A. Tchaikovsky “Tale of Boris and Gleb”-the study of the characteristics of drama and musical language, as well as its stage interpretation. The justification of the director's decision, relying on plastic, is due to the original interpretation of the genre by composer: with a bias towards an oratorio and an instrumental concert, with an active juxtaposition of speech and music, with a combination of monumentality and dynamism, academic seriousness and democratic openness.
“Count Castelli” by Ivan Walberch: Ballet to the Combined Music
Authors: Максимова Александра Евгеньевна 
Published: February 2021

В статье представлен балет первого русского хореографа И. Вальберха «Граф Кастелли» на музыку нескольких авторов: С. Давыдова, В. Мартин-и-Солера, Дж. Сарти. Поставлена проблема специфики балетов на сборную музыку. Освещена история создания и исполнения сочинения, изучено оригинальное либретто балета. Рассмотрена редкая рукопись - комплект оркестровых голосов, воссоздан композиционный план балета. Установлено авторство Сарти и Мартин-и-Солера в двух номерах балета, определены цитированные фрагменты.
The article presents I. Walberch’s ballet “Count Castelli” to the music of several authors: J. Sarti, V. Martin-y-Soler, S. Davydov. The problem of peculiarities of ballets for combined music is posed. The history of the creation and production of the composition is covered, the libretto of the composition and the plot of the ballet are found and studied. A rare source, a handwritten set of orchestraL voices, is considered, the compositional plan of the ballet is restored. The authorship of Sarti and Martin-y-Soler in two ballet numbers is established, the initial sources of fragments are determined.
Instrumentation in Condition of Real and Virtual Acoustics Around Music
Authors: Красильников Игорь Михайлович 
Published: February 2021

Инструментовкой сегодня занимаются не только композиторы, создающие оркестровые партитуры, но и широкий круг музыкантов - профессионалов и любителей, работающих в различных жанрах электронной музыки. Электронная инструментовка имеет много общего с ее традиционным видом, поскольку в обоих случаях решаются одинаковые задачи: реализация колористического потенциала исходного текста, выстраивание композиционной формы с помощью выделения ее разделов, выстраивание фактуры путем заполнения акустического пространства и прорисовки ее пластов. Различия же обусловлены разной природой музыкального материала. В одном случае - это звучание оркестровых инструментов в концертном зале или на открытом воздухе. В другом - это множество синтезированных звуков в условиях виртуальной акустики, которая может быть представлена в самых разных вариантах. Электронная инструментовка, опираясь на сложившиеся в многовековой академической практике приемы, обогащается за счет использования новых звуков и возможностей управления виртуальным пространством их развертывания.
Today, not only composers who create orchestral scores are engaged in instrumentation, but also a wide range of musicians-professionals and amateurs working in various genres of electronic music. Electronic instrumentation has a lot in common with its traditional form, since in both cases the same tasks are solved: realizing the color potential of the source text, building a compositional form by highlighting its sections, building a texture by filling the acoustic space and drawing its layers. The differences are due to the different nature of the sound material. In one case, it is the sound of orchestral instruments in a concert hall or in the open air. In the other case, it is a variety of synthesized sounds in a virtual acoustic environment, characterized by diversity and variability. Therefore, electronic instrumentation, based on the techniques developed in centuries-old practice, is enriched by the use of these new sounds and the ability to manage the virtual space of their deployment.