bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of nutrition education by health professionals on pregnancy-specific nutrition knowledge and healthy dietary practice among pregnant women in Asmara, Eritrea: a quasi-experimental study
Authors: Teweldemedhin Lidia Ghirmai , Amanuel Helen Gebretatyos , Berhe Soliana Amanuel , Gebreyohans Ghidey , Tsige Zemenfes , Habte Eyasu 
Published: April 2021

BackgroundHealthy pregnancy and birth outcomes are greatly influenced by the intake of adequate and balanced nutrition. Pregnant women’s nutritional knowledge and practice have been identified as an important prerequisites for their proper nutritional intake. The antenatal period with the opportunities for regular contact with health professionals appears to be the ideal time and setting to institute the intervention which could maximise pregnant women’s outcome and that of their baby by motivating them to make nutritional changes.ObjectiveTo assess the effect of nutrition education on the appropriate nutritional knowledge and practice of pregnant women.MethodologyA facility-based single-group pre–post quasi-experimental study design was employed in five health facilities providing antenatal care (ANC) service in Asmara on 226 pregnant women. A predesigned and pretested questionnaire was used to collect data regarding nutritional knowledge via interview by trained data collectors during the pretest, immediate post-test and 6 weeks later. The practice was assessed at pre-intervention and 6 weeks later only. Repeated measures analysis of variance and paired t-test were used to make comparisons in knowledge and practice scores, respectively, using SPSS (V.22).ResultsTraining provided to pregnant women resulted in a significant increase on the mean scores of their knowledge from 29.01/47 (SE=0.35) pre-intervention to 42.73/47 (SE=0.24) immediate post-intervention. However, the score declined significantly from immediate after intervention to 6-week follow-up by 1.79 (SE=0.22). Although the score declined, knowledge at 6-week follow-up was still significantly greater than that of pre-intervention (p<0.0001). Health professionals (70.2%) were the primary source of information for pregnant women. The pregnancy-specific dietary practice score at 6-week follow-up (M=13.13/16, SE=0.09) was significantly higher than that of pre-intervention (M=12.55/16, SE=0.16). There was no significant interaction between the categories of demographic characteristics and change in practice and knowledge.ConclusionThis study has shown that the nutrition messages given to pregnant women by trained health professionals using a holistic approach in a sustained manner played a huge role in increasing their knowledge and in introducing positive dietary practices among them. Thus, ANC clinics must play a leading role in coordinating the effort of awareness creation regarding nutrition during pregnancy.
Residential area and screening venue location features associated with spatial variation in breast cancer screening invitation response rates: an observational study in Greater Sydney, Australia
Authors: Khan Jahidur Rahman , Carroll Suzanne Jane , Warner-Smith Matthew , Roder David , Daniel Mark 
Published: April 2021

ObjectivesParticipation in breast cancer screening (BCS) varies at the small-area level, which may reflect environmental influences. This study assessed small-area variation in BCS invitation response rates (IRRs) and associations between small-area BCS IRR, sociodemographic factors, BCS venue distance and venue location features in Greater Sydney, Australia.MethodsBCS IRR data for 2011–2012 were compiled for 9528 Australian Bureau of Statistics Statistical Area Level 1 (SA1) units (n=227 474 women). A geographial information system was used to extract SA1-level sociodemographic features (proportions of women speaking English at home, full-time employed and university educated, and proportion of dwellings with motor vehicles), SA1-level distance to closest venue(s) (expressed as quartiles), and closest venue(s) colocated with bus stops, train station, hospital, general practitioner and shops. Associations between area-level features, BCS venue distance, venue location features and IRR were estimated using ordinary least square-type spatial lag models including area education as a covariate.ResultsBCS IRR varied across SA1s (mean=59.8%, range: 0%–100%), with notable spatial autocorrelation (Moran’s I=0.803). BCS IRR was positively associated with greater SA1-level proportion of women speaking English at home (β=2.283, 95% CI 2.024 to 2.543), women’s education (in the model including speaking English at home β=0.454, 95% CI 0.211 to 0.697), dwellings with motor vehicles (β=1.836, 95% CI 1.594 to 2.078), greater distance to venue (eg, most distant quartile compared with closest: β=6.249, 95% CI 5.489 to 7.008), and BCS venue colocated with shops (β=0.762, 95% CI 0.273 to 1.251). Greater SA1-level women employment (β=−0.613, 95% CI −0.898 to −0.328) and venue colocated with train station (β=−1.889, 95% CI −2.376 to −1.402) or hospital (β=−0.677, 95% CI −1.164 to −0.189) were inversely related to BCS IRR.ConclusionsSmall-area variation in BCS IRR exists for Greater Sydney and is strongly related to sociodemographic factors that, together with BCS venue location features, could inform targeted attempts to improve IRR.
Delivering screening programmes in primary care: protocol for a scoping and systematic mixed studies review
Authors: Modi Rakesh Narendra , Kelly Sarah , Hoare Sarah , Powell Alison , Kuhn Isla , Usher-Smith Juliet , Mant Jonathan , Burt Jenni 
Published: April 2021

IntroductionScreening programmes represent a considerable amount of healthcare activity. As complex interventions, they require careful delivery to generate net benefit. Much screening work occurs in primary care. Despite intensive study of intervention delivery in primary care, there is currently no synthesis of the delivery of screening programmes in this setting. The purpose of this review is to describe and critically evaluate the delivery of screening programmes in general practice and community services.Methods and analysisWe will use scoping review methods to explore which components of screening programmes are delivered in primary care and systematic review methods to locate and synthesise evidence on how screening programmes can be delivered in primary care, including barriers, facilitators and strategies. We will include empirical studies of any design which consider screening programmes in high-income countries, based in part or whole in primary care. We will search 20 information sources from 1 January 2000, including those relating to health (eg, MEDLINE, Embase, CINAHL), management (eg, Rx for change database) and grey literature (eg, OpenGrey, screening committee websites). Two reviewers will screen citations and full texts of potentially eligible studies and assess these against inclusion criteria. Qualitative and quantitative data will be extracted in duplicate and synthesised using a best fit framework approach. Within the systematic review, the mixed methods appraisal tool will be used to assess risk of bias.Ethics and disseminationNo ethics approval is required. We will disseminate findings to academics through publication and presentation, to decision-makers through national screening bodies, to practitioners through professional bodies, and to the public through social media.PROSPERO registration numberCRD42020215420.
Walrus large bore guide catheter impact on recanalization first pass effect and outcomes: the WICkED study
Authors: Cortez Gustavo M , Turner Raymond D , Monteiro Andre , Puri Ajit S , Siddiqui Adnan H , Mocco J , Vargas Jan , Kuhn Anna L , Majidi Shahram , Chaudry M Imran , Aghaebrahim Amin , Turk Aquilla S , Sauvageau Eric , Hanel Ricardo A 
Published: April 2021

BackgroundThe use of a balloon-guide catheter (BGC) in acute stroke treatment has been widely adopted after demonstrating optimized procedure metrics and outcomes. Initial technical constraints of previous devices included catheter stiffness and smaller inner diameters. We aim to evaluate the performance and safety of the Walrus BGC, a variable stiffness catheter with a large bore 0.087 inch inner diameter (ID), via the the WICkED study (Walrus Large Bore guide CatheterImpact on reCanalization first passEffect anDoutcomes).MethodsThis is a retrospective, site adjudicated, multicenter study on consecutive patients with large vessel occlusion treated with the Walrus BGC. Baseline characteristics, procedural outcomes and functional outcomes were analyzed.ResultsA total of 338 patients met the inclusion criteria. The Walrus was successfully tracked into distal vasculature and allowed therapeutic device delivery in all but 3 cases (0.9%). Large aspiration catheters ≥0.070 inch ID were used in 71.9% of cases. Stent retriever thrombectomy was used as the first-line modality in 59.2% and thromboaspiration in 40.8% of cases. The successful recanalization rate (modified treatment in cerebral ischemia (mTICI) 2b/3) was 94.4%, with 64.8% of the patients achieving mTICI 2b/3 after the first pass. The Walrus-related adverse event rate was 0.6%, corresponding to two vessel dissections. Functional independence was 50% (126/252) and mortality 25% (63/252). Unfavorable outcomes were more likely in older patients, who had unsuccessful reperfusion, longer procedure times, and a higher mean number of passes.ConclusionIn acute ischemic stroke patients presenting with large vessel occlusion, the Walrus BGC demonstrated excellent navigability and safety profile, allowed the accommodation of leading large bore aspiration catheters, and demonstrated high vessel recanalization rates.
Moving Toward the Ideal Autologous Adoptive T-cell Therapy for Cancer
Authors: Ladle Brian H. 
Published: April 2021

Abstract
Despite being one of the earliest immunotherapies to prove that the immune system can effectively recognize and eradicate cancer, autologous adoptive T-cell therapies remain largely limited to academic centers and research trials. The highly individualized protocols and the heterogeneous nature of the expanded T-cell products hinder effectiveness, commercial development, and regulatory approvals. The report by Li and colleagues details a novel method of generating cancer-specific autologous T cells from patients receiving anti-PD-1 checkpoint blockade immunotherapy. Their method achieved promising results in four initial patients treated in a pilot study. While further studies are required to characterize the autologous T-cell products generated and their effectiveness in larger cohorts of patients, the protocol they describe addresses several of the roadblocks that have prevented more wide-spread use of autologous adoptive T-cell therapy.
See related article by Li et al., p. 2184
Pensando os Arranjos Intermunicipais no Combate à Desigualdade: um estudo de quatro consórcios
Authors: Laczynski Patricia 
Published: April 2021

Este trabalho objetiva responder a duas perguntas: será que os consórcios são arranjos regionais possíveis de efetivarem políticas de combate à desigualdade? Serão os consórcios capazes de pensar a governança intermunicipal, a partir da redistribuição? Como o Brasil é um dos campeões de desigualdade, procurou-se aprofundar a discussão prática da desigualdade e procurar caminhos a partir das sub regiões de se implementar políticas redistributivas. O objeto de análise da pesquisa são os consórcios intermunicipais. Metodologicamente, foram realizados estudos de quatro consórcios nas áreas de desenvolvimento e saúde. Conclui-se que os consórcios são capazes de implementar políticas quase-redistributivas, uma vez que suas ações beneficiam um grupo muito grande da sociedade, mas o custo não se origina de outro grupo social específico, mas de toda uma região.
Gender issues in fundamental physics: A bibliometric analysis
Authors: Strumia Alessandro 
Published: April 2021

AbstractI analyze bibliometric data about fundamental physics worldwide from 1970 to now, extracting quantitative data about gender issues. I do not find significant gender differences in hiring rates, hiring timing, career gaps and slowdowns, abandonment rates, citation, and self-citation patterns. Furthermore, various bibliometric indicators (number of fractionally counted papers, citations, etc.) exhibit a productivity gap at hiring moments, at career level, and without integrating over careers. The gap persists after accounting for confounding factors and manifests as an increasing fraction of male authors going from average to top authors in terms of bibliometric indices, with a quantitative shape that can be fitted by higher male variability.
A Case Report of Breast Implant–Associated Anaplastic Large-Cell Lymphoma in a PALB2 Mutation–Positive Woman
Authors: Bonev Valentina 
Published: April 2021

Breast implant–associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare peripheral T-cell lymphoma composed of anaplastic pleomorphic T cells. The first case was reported in 1997 but was not recognized until 2016 by the World Health Organization. The exact incidence is unknown but is estimated to be 0.1 to 0.3 per 100,000 women with implants. Almost every case has been found in women with textured breast implants. The median time of onset after implantation is 10.7 years. Patients presenting with localized disease, most commonly manifesting as breast enlargement, can be managed solely with surgical resection and have a 100% survival rate. This report describes a PALB2 mutation–positive woman with a strong family history of breast cancer who underwent prophylactic bilateral nipple-sparing mastectomy with textured silicone implant placement. She was diagnosed with BIA-ALCL less than 4 years later after seroma aspiration. She was treated with implant removal and capsulectomy; but, surprisingly, final surgical pathology did not show any malignancy.
The Assessment of Regional Liver Function Before Major Hepatectomy Using Magnetic Resonance Imaging
Authors: Kudo Masashi , Gotohda Naoto , Sugimoto Motokazu , Konishi Masaru , Takahashi Shinichiro , Kobayashi Shin , Kobayashi Tatsushi 
Published: April 2021

Background The liver-to-spleen signal intensity ratio (LSR) on magnetic resonance imaging with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid has been used as a parameter to assess liver function. LSR of the future remnant liver region (FR-LSR) is included in preoperative assessment of regional liver function. The aim of this study was to investigate the predictability of post-hepatectomy liver failure (PHLF) by FR-LSR. Methods Between May 2013 and May 2019, 127 patients underwent standardized EOB-MRI for diagnosis of liver tumor before major hepatectomy. The FR-LSR on EOB-MRI was calculated by a semiautomated three-dimensional volumetric analysis system. The cutoff value of FR-LSR in association with clinically relevant PHLF was determined according to the areas under the receiver operating characteristic curves. Then, FR-LSR and clinical variables were analyzed to assess the risk of clinically relevant PHLF. Results In patients with preoperative biliary drainage, metastatic liver tumor, estimated future remnant liver volume <50%, biliary reconstruction, operation time ≥ 480 min, estimated blood loss ≥ 1000 g, blood transfusion and a FR-LSR < 2.00 were associated with clinically relevant PHLF ( P < .05 for all) in univariable analysis. The liver-to-spleen signal intensity ratio of the future remnant liver region < 2.00 was the only independent risk factor for clinically relevant PHLF in multivariable risk analysis (OR, 27.90; 95% CI: 7.99-136.40; P < .05). Discussion The present study revealed that FR-LSR calculated using a 3-dimensional volumetric analysis system was an independent risk factor for clinically relevant PHLF. The liver-to-spleen signal intensity ratio of the future remnant liver region might be a reliable preoperative parameter in liver functional assessment, enabling safe performance of major hepatectomy.
Behind the screen of voluntary psychiatric hospital admissions: A qualitative exploration of treatment pressures and informal coercion in experiences of patients in Italy, Poland and the United Kingdom
Authors: Klingemann Justyna , Świtaj Piotr , Lasalvia Antonio , Priebe Stefan 
Published: April 2021

Background: Despite the extensive research and intense debate on coercion in psychiatry we have seen in recent years, little is still known about formally voluntarily admitted patients, who experience high levels of perceived coercion during their admission to a psychiatric hospital. Aims: The purpose of the present research was to explore forms of treatment pressure put on patients, not only by clinicians, but also by patients’ relatives, during admission to psychiatric hospitals in Italy, Poland and the United Kingdom. Methods: Data were obtained via in-depth, semi-structured interviews with patients ( N = 108) diagnosed with various mental disorders (ICD-10: F20–F49) hospitalised in psychiatric inpatient wards. Maximum variation sampling was applied to ensure the inclusion of patients with different socio-demographic and clinical characteristics. The study applied a common methodology to secure comparability and consistency across participating countries. The qualitative data from each country were transcribed verbatim, coded and subjected to theoretical thematic analysis. Results: The results of the analysis confirm that the legal classifications of involuntary and voluntary hospitalisation do not capture the fundamental distinctions between patients who are and are not coerced into treatment. Our findings show that the level of perceived coercion in voluntary patients ranges from ‘persuasion’ and ‘interpersonal leverage’ (categorised as treatment pressures) to ‘threat’, ‘someone else’s decisions’ and ‘violence’ (categorised as informal coercion). Conclusion: We suggest that the term ‘treatment pressures’ be applied to techniques for convincing patients to follow a suggested course of treatment by offering advice and support in getting professional help, as well as using emotional arguments based on the personal relationship with the patient. In turn, we propose to reserve the term ‘informal coercion’ to describe practices for pressuring patients into treatment by threatening them, by making them believe that they have no choice, and by taking away their power to make autonomous decisions.
“Jumping the Shark”: An Interdisciplinary Activity for Engaging Students With the Principles of Bivariate Regression
Authors: Watson Todd D. 
Published: April 2021

Background: Student anxiety about statistics may lead to poorer learning outcomes. Objective: The purpose of this study was to evaluate an exercise designed to teach students in an introductory statistics class the principles of bivariate regression and to emphasize how statistical tools used by psychologists are also implemented in other fields. Method: Students used a published model on the relationship between tooth size and the length of great white sharks to estimate the length of extinct sharks and to explore factors that could affect the accuracy or validity of regression analyses. Data from an anonymous self-report scale were used to assess the activity. Results: More than 95% of respondents agreed or strongly agreed that the activity was engaging, approximately 95% of students agreed or strongly agreed that the activity helped them learn about factors that can lead to problems with bivariate correlation/regression, and approximately 91% of respondents correctly answered a question designed to assess basic content acquisition. Conclusion: Feedback data suggest that the exercise was successful in achieving its content and process learning goals. Teaching Implications: Implementation of similar exercises may improve student engagement and outcomes in psychology statistics courses.
Aorto-left common carotid artery bypass with off-pump coronary artery bypass
Authors: Nagata Tomoki , Yamada Takashi , Johno Hiroyuki 
Published: April 2021

Background Although carotid artery disease can occur in patients who have coronary artery disease (CAD), ostial stenosis of a left common carotid artery (CCA) along with CAD is a rarely reported condition. Case report We describe a rare case of severe stenosis of the left CCA ostium and CAD, which were successfully treated with an off-pump coronary artery bypass and aorto-left CCA bypass. This strategy minimizes the risk of perioperative strokes. Furthermore, an aorto-supra aortic trunk bypass provides a more physiological blood flow pattern than cerebral approaches. This approach would be a safe and effective treatment option.
Pneumomediastinum in COVID-19 disease: Outcomes and relation to the Macklin effect
Authors: Brito João , Gregório Paulo , Mariani Alessandro , D’ambrosio Paula , Filho Mauro , Ferreira Lorena , Sawamura Marcio , Pêgo-Fernandes Paulo Manuel 
Published: April 2021

Aim Pneumomediastinum (PM) is associated with several etiologies and mechanisms. Although it has been described more than 100 years ago, the literature is limited to small retrospective studies. This study aimed to follow patients with coronavirus disease (COVID-19) that developed PM during hospitalization and describe their clinical and radiological evolution. Methods A prospective cohort was developed with patients with PM, excluding those with aerodigestive trauma, inside a hospital COVID-19 dedicated hospital. Clinical variables including onset of symptoms, hemodynamic instability, associated complications, the need of interventions, and disease course were all recorded. Also, radiological findings such as the presence of the Macklin effect, extension of lung involvement by COVID-19, and characteristics of the PM were analyzed. Results Twenty-one patients with non-traumatic PM were followed, resulting in an overall incidence of 0.5% during the study period. Seven (33%) patients had associated pneumothorax and malignant/tension PM was observed in three (14%) cases. The Macklin effect could be found in 11 patients (52%) and the majority of them had more than 50% of lung involvement due to COVID-19. The mortality rate was 49%; however, no deaths were directly related to the PM. Conclusions PM incidence is probably increased in the severe acute respiratory syndrome caused by COVID-19, especially in those with greater involvement of the lungs, and the Macklin effect may be an important underlying mechanism of this complication. Usually, PM has a benign course, but complications like tension/malignant PM may occur requiring prompt detection and intervention.