bluuebunny/crossref_metadata_2025_split huggingface dataset:
Congreso Nacional de Ciencia y Tecnología – APANAC : Acta de artículos 2021
Authors: Sanchez-Galan Javier E. , Fábrega José 
Published: August 2021

El ecosistema de Ciencia, Tecnología e Innovación de Panamá, sin lugar a duda, ha crecido y se fortalecido en los últimos años. Este crecimiento se puede contabilizar y está ligado al crecimiento del número de nuevos investigadores y los proyectos de investigación e innovación que estos realizan a través de las diversas unidades de investigación (Universidades, Institutos Nacionales y Centros de Investigación, entre otros). Por otro lado, se puede decir que este crecimiento es sistemático y reflejado por el grado de los compromisos adquiridos a nivel del Gobierno de la República de Panamá a través del Plan Estratégico de Gobierno 2019-2024 y Los Planes Estratégicos Nacional de Ciencia, Tecnología e Innovación (PENCYT 2019-2024), ambos en vigencia y puestos en práctica actualmente. La Asociación Panameña para el Avance de la Ciencia (APANAC) es una organización sin fines de lucro fundada en 1985, cuya misión es trabajar para la promoción de la ciencia y la tecnología como base del desarrollo nacional. El Congreso Nacional de Ciencia y Tecnología es el evento científico más importante de Panamá y se ha llevado a cabo con frecuencia inter-anual desde 1995. Este año estaremos realizando su XVIII edición de manera virtual algo que ha sido un reto enorme, y que a la vez lo hace muy especial, ya que indica nuestra resiliencia. Este Congreso tiene como objetivo principal servir como plataforma para el intercambio de experiencias entre científicos, tecnólogos, empresarios, la sociedad civil y todos los ciudadanos que buscan mejorar la ciencia y tecnología en nuestro país.
Como objetivo secundario es visualizar las labores de investigación e innovación que se realizan a nivel nacional, a nivel regional y a nivel internacional por investigadores, estudiantes y personal de investigación en diversas unidades de Investigación. Esta labor de visualizar es quizás el mayor reto dado por la virtualidad, pero sin lugar a dudas las Tecnologías de Información y Comunicación están allí para ayudarnos a sacar el mejor provecho.Agradecemos especialmente a la SENACYT, por el apoyo constante a la realizacion del Congreso. En esta XVIII version tambien agradecmos al apoy logistico de la Ciudad del Saber y a las gestiones realizadas por la Embajada del Estado de Israel en Panamá asegurar participación de muchos de los prestigiosos expositores invitados.
Methylprednisolone Plasma Concentrations During Cardiac Surgery With Cardiopulmonary Bypass in Pediatric Patients
Authors: van Saet Annewil , Zeilmaker-Roest Gerdien A. , Veen Kevin M. , de Wildt Saskia N. , Sorgel Fritz , Stolker Robert J. , Bogers Ad J. J. C. , Tibboel Dick 
Published: August 2021

Introduction:To our knowledge, methylprednisolone pharmacokinetics and plasma concentrations have not been comprehensively investigated in children with congenital heart disease undergoing cardiac surgery with cardiopulmonary bypass. It is unknown whether there is a significant influence of cardiopulmonary bypass on the plasma concentrations of methylprednisolone and whether this may be an explanation for the limited reported efficacy of steroid administration in cardiac surgery with cardiopulmonary bypass.Methods:The study was registered in the Dutch Trial Register (NTR3579;https://www.trialregister.nl/trial/3428). Methylprednisolone 30 mg/kg was administered as an intravenous bolus after induction of anesthesia. Methylprednisolone concentration was measured with liquid chromatography tandem mass spectrometry and analyzed using linear mixed-effects modeling.Results:Thirty-nine patients were included in the study, of which three were excluded. There was an acute decrease in observed methylprednisolone plasma concentration on initiation of cardiopulmonary bypass (median = 26.8%, range = 13.9–48.14%,p&lt; 0.001). We found a lower intercept (p= 0.02), as well as a less steep slope of the model predicted methylprednisolone concentration vs. time curve for neonates (p= 0.048). A lower intercept (p= 0.01) and a less steep slope (p = 0.0024) if the volume of cell saver blood processed was larger than 91 ml/kg were also found.Discussion:We report similar methylprednisolone plasma concentrations as earlier studies performed in children undergoing cardiopulmonary bypass, and we confirmed the large interindividual variability in achieved methylprednisolone plasma concentrations with weight-based methylprednisolone administration. A larger volume of distribution and a lower clearance of methylprednisolone for neonates were suggested. The half-life of methylprednisolone in our study was calculated to be longer than 6 h for neonates, 4.7 h for infants, 3.6 h for preschool children and 4.7 h for school children. The possible influence of treatment of pulmonary hypertension with sildenafil and temperature needs to be investigated further.
Vacteens.org: A Mobile Web app to Improve HPV Vaccine Uptake
Authors: Woodall W. Gill , Zimet Gregory , Kong Alberta , Buller David , Reither Jeannyfer , Chilton Lance , Myers Valerie , Starling Randall 
Published: August 2021

U.S. HPV vaccine uptake remains below the Healthy People 2030 goal of 80% series completion. Parental concerns and misinformation about the efficacy and safety of the Human Papillomavirus (HPV) vaccine remain, and may be addressed by digital interventions tailored to their concerns. Reported here are results from a small scale randomized trial testing a mobile web app for parents and their adolescent daughters (ages 11–14 years) encouraging HPV vaccination in New Mexico, an ethnically-diverse U.S. state.Methods: A clinic-cluster randomized trial where pediatric clinics (n = 9) were recruited and randomized, and parent-adolescent pairs (n = 82) within clinics received either the Vacteens.org/Vacunadolescente.org mobile web app or Usual and Customary (UC) HPV Vaccination information. Parents completed online surveys at baseline and 3-months. Daughters' HPV vaccine data were collected from the New Mexico State Immunization Information System 1 year post baseline.Results: Three month survey results found Vacteens.org/Vacunadolescente.org parents to have higher positive HPV vaccine beliefs, informed decision making, intent to vaccinate and vaccine confidence outcomes than UC parents. HPV vaccine data found higher first dose HPV vaccination (Pearson χ2 = 6.13, p = 0.013, Vacteens.org/Vacunadolescente.org group 59.4%, UC group 40.6%), and higher HPV vaccination series completion (Pearson χ2 = 6.49, p = 0.011, Vacteens.org/Vacunadolescente.org group 68.4%, UC group 31.6%).Conclusions: The small trial results showed the Vacteens.org/Vacunadolescente.org web app prompted positive vaccine-related attitudes and beliefs, and more HPV vaccination initiation and series completion. Mobile web apps can make decision-making tools for HPV vaccination widely available on digital platforms, reducing vaccine hesitancy, and confusion and increase HPV vaccine uptake.
The Internet-Based Conversational Engagement Clinical Trial (I-CONECT) in Socially Isolated Adults 75+ Years Old: Randomized Controlled Trial Protocol and COVID-19 Related Study Modifications
Authors: Yu Kexin , Wild Katherine , Potempa Kathleen , Hampstead Benjamin M. , Lichtenberg Peter A. , Struble Laura M. , Pruitt Patrick , Alfaro Elena L. , Lindsley Jacob , MacDonald Mattie , Kaye Jeffrey A. , Silbert Lisa C. , Dodge Hiroko H. 
Published: August 2021

Background: Increasing social interactions through communication technologies could offer a cost-effective prevention approach that slows cognitive decline and delays the onset of Alzheimer's disease. This paper describes the protocol of an active project named “Internet-based conversational engagement clinical trial (I-CONECT)” (ClinicalTrials.gov: NCT02871921). The COVID-19 pandemic related protocol modifications are also addressed in the current paper.Methods: I-CONECT is a multi-site, assessor-blind, randomized controlled behavioral intervention trial (RCT). We aim to randomize 320 socially isolated adults 75+ years old [160 Caucasian and 160 African American participants, 50:50 split between those with normal cognition and mild cognitive impairment (MCI)] recruited from the community to either the video chat intervention group or the control group (1:1 allocation). Those in the video chat group receive a computer and Internet service for the duration of the study, which they use to video chat with study staff for 30 min/day 4×/week for 6 months (high dose), and then 2×/week for an additional 6 months (maintenance dose). Both video chat and control groups have a brief (about 10 min) telephone check-in with study staff once per week. The primary outcome is the change in global cognitive function measured by Montreal Cognitive Assessment (MoCA) from baseline to 6 months. Secondary outcomes include changes in cognition in memory and executive function domains, emotional well-being measured by NIH Toolbox emotional battery, and daily functional abilities assessed with the Revised Observed Tasks of Daily Living (OTDL-R). Eligible participants have MRIs at baseline and 6 months. Participants contribute saliva for genetic testing (optional consent), and all video chats, weekly check-in calls and neuropsychological assessment sessions are recorded for speech and language analysis. The pandemic halted research activities and resulted in protocol modifications, including replacing in-person assessment with remote assessment, remote deployment of study equipment, and revised targeted sample size.Discussion: This trial provides user-friendly hardware for the conversational-based intervention that can be easily provided at participants' homes. The trial aspires to use age and culture-specific conversational materials and a related platform developed in this trial for enhancing cognitive reserve and improving cognitive function.
Improving the Specular Point Positioning Accuracy of Ship-Borne GNSS-R Observations in China Seas Based on Comprehensive Geophysical Correction
Authors: Wu Fan , Zheng Wei , Liu Zongqiang , Sun Xuezhi 
Published: August 2021

The accurate modeled GNSS-R reflection delay, which is indispensable for the quantification, modeling, and correction of the GNSS-R altimetry sea-state bias, can be obtained based on the accurate modeled position of the specular point. At present, the reflection surface model of the specular point positioning still has the mean dynamic topography (MDT) error and the deviation of the vertical (DOV) error relative to the instantaneous sea surface. In this study, the following studies have been carried out. Based on the ship-borne GNSS-R observations in China seas, we introduced various elevation parameters including the MDT to correct the elevation error of the reflection surface. We introduced the DOV based on the elevation correction, and the DOV correction positioning method was proposed to correct the slope error of the reflection surface. The specular point was positioned on the instantaneous sea reflection surface. We verified the instantaneous sea reflection surface model and the specular point positioning results, analyzed the relationship between the position correction distance and the reflection incident angle, and discussed the spatial distribution characteristics of the MDT correction distance. The results showed that the reflection surface modeling and the specular point positioning were accurate. The positioning error increased to varying degrees with the increase of the reflection incident angle. The MDT correction improved the positioning by 0.91 m, and the DOV correction further improved the positioning by 0.12 m. Based on the combined application of the two kinds of correction positioning, the positioning was comprehensively improved by 0.99 m. The MDT correction of China seas gradually increased from the north to south. While in the regional sea areas, it gradually decreased from the north to south and showed randomness. The relative position between the antennas and their random changes introduced uncertainty, which can be reduced by integration. The new instantaneous sea reflection surface model and the corresponding specular point positioning method can provide accurate modeled reflection delay for the sea-state bias correction of ship-borne GNSS-R observations, and they can be extended to satellite-borne global observations.
Case Report: Phototherapeutic Keratectomy for Band Keratopathy Secondary to Chemo-Laser-Cryotherapy for Retinoblastoma
Authors: Wei Ruoyan , Li Meiyan , Yang Weiming , Xu Haipeng , Choi Joanne , Zhou Xingtao 
Published: August 2021

Purpose: To report the clinical outcomes of phototherapeutic keratectomy (PTK) for pediatric band keratopathy after treatment for retinoblastoma.Methods: A 5-year-old boy presented with a 2-year history of poor visual acuity and a horizontal gray-white band across the central cornea in the right eye. He was diagnosed with band keratopathy after chemo-laser-cryotherapy for retinoblastoma. The band keratopathy was treated via PTK using the Mel-90 excimer laser with an optical treatment zone of 7.0 mm and ablation depth of 120 μm. The patient was followed at 1 week and 3 months postoperatively.Results: Surgery and postoperative follow-up were uneventful. At the 3-month follow-up, the uncorrected distant visual acuity of the right eye improved to 20/125, and the corrected distance visual acuity improved to 20/70 with a refraction of +10.00 D/−2.50 DC × 15. The clarity of the ablated area was evidently improved. The central corneal thickness decreases from 612 to 584 μm. The optical coherence tomography showed the thin band of hyperreflectivity in the ablated area disappeared, corneal transparency improved and the corneal surface smoothened.Conclusions: PTK is a safe and effective procedure to treat band keratopathy following treatment of retinoblastoma in children. Early intervention can reduce the risk of developing deprivation amblyopia.
Memory Clinics and Day Care Centers in Thessaloniki, Northern Greece: 30 Years of Clinical Practice and Experience
Authors: Tsolaki Magda , Tsatali Marianna , Gkioka Mara , Poptsi Eleni , Tsolaki Anthoula , Papaliagkas Vasileios , Tabakis Irene-Maria , Lazarou Ioulietta , Makri Marina , Kazis Dimitrios , Papagiannopoulos Sotirios , Kiryttopoulos Andreas , Koutsouraki Efrosyni , Tegos Thomas 
Published: August 2021

Background: This review describes the diagnostic and interventional procedures conducted in two university memory clinics (established network of G. Papanikolaou Hospital: 1988–2017 and AHEPA hospital: 2017–today) and 2 day care centers (established network of DCCs: 2005–today) in North Greece and their contribution in the scientific field of dementia. The aims of this work are (1) to provide a diagnosis and treatment protocol established in the network of memory clinics and DCCs and (2) to present further research conducted in the aforementioned network during the last 30 years of clinical practice.Methods: The guidelines to set a protocol demand a series of actions as follows: (1) set the diagnosis criteria, neuropsychological assessment, laboratory examinations, and examination of neurophysiological, neuroimaging, cerebrospinal fluid, blood, and genetic markers; and (2) apply non-pharmacological interventions according to the needs and specialized psychosocial interventions of the patient to the caregivers of the patient.Results: In addition to the guidelines followed in memory clinics at the 1st and 3rd Department of Neurology and two DCCs, a database of patients, educational programs, and further participation in international research programs, including clinical trials, make our contribution in the dementia field strong.Conclusion: In the current paper, we provide useful guidelines on how major and minor neurocognitive disorders are being treated in Thessaloniki, Greece, describing successful practices which have been adapted in the last 30 years.
Effect of Anodal Transcranial Direct Current Stimulation Combined With Cognitive Training for Improving Cognition and Language Among Children With Cerebral Palsy With Cognitive Impairment: A Pilot, Randomized, Controlled, Double-Blind, and Clinical Trial
Authors: Ko Eun Jae , Hong Mi Jin , Choi Eun Jung , Yuk Jin Sook , Yum Mi Sun , Sung In Young 
Published: August 2021

About 30–45% of cerebral palsy (CP) patients have cognitive impairment. Previous studies showed the evidence that transcranial direct current stimulation (tDCS) may have some benefits in attention-deficit/hyperactivity disorder, autism spectrum disorder, and motor development in CP. The aim of this study is to evaluate the effect of tDCS on cognition, language, and activities of daily living (ADL) among children with CP with cognitive impairment. It was a pilot, randomized, controlled, double-blind, clinical trial in a tertiary pediatric hospital, and 13 children with CP and a cognitive age under 42 months were enrolled. tDCS group (n = 8) had active tDCS and cognitive training (20 min/session, total 20 sessions, for 12 weeks) and sham group (n = 5) had sham tDCS and cognitive training. Primary outcome was the Bayley Scales of Infant Development II (BSID II). Secondary outcomes were the Pediatric Evaluation of Disability Inventory (PEDI), the Laboratory Temperament Assessment Battery (Lab-TAB), the Early Childhood Behavior Questionnaire (ECBQ), the Korean version of MacArthur–Bates Communicative Development Inventories (M-B CDI-K), the Sequenced Language Scale for Infants (SELSI) and the Preschool Receptive-Expressive Language Scale (PRES). After intervention, the tDCS group showed significant improvements in all measurements (p &lt; 0.05) except the M-B CDI-K (grammar), whereas the sham group only showed significant improvements in the Lab-TAB (manipulation domain), the ECBQ (attentional shifting), and the M-B CDI-K (comprehension). The between-group differences in the degree of post-intervention improvement were not statistically significant. The degree of improvement was associated with better baseline cognitive function and younger age (p &lt; 0.05). There were no major adverse events after tDCS. The combined application of tDCS and cognitive training was feasible and associated with improvements in cognitive function, ADL, and language among children with CP with cognitive impairment. However, considering that it is a pilot study, further larger-scale systematic investigation is needed.Clinical Trial Registration: The trial was registered in the Clinical Research Information Service database, identifier: KCT0003023.
The Prevalence of Psychological Symptoms in Pregnant Healthcare Workers (HCWs) and Pregnant Non-HCWs During the Early Stage of COVID-19 Pandemic in Chongqing, China
Authors: Liu Min , Li Nan , Cai Xianghao , Feng Xiaoyan , Wang Rong , Xiong Peng 
Published: August 2021

Background: Studies showed that healthcare workers (HCWs) and pregnant women bore the burden of mental problems during the coronavirus disease 2019 (COVID-19) pandemic. While, few studies have focused on the psychological impact of COVID-19 pandemic on pregnant women who work at healthcare settings. This study aimed to investigate and compare the prevalence difference of psychological symptoms between pregnant HCWs and pregnant non-HCWs during the early stage of COVID-19 pandemic in China.Methods: A cross-sectional online survey with anonymous structured questionnaires was conducted from February 15 to March 9, 2020. A total of 205 pregnant women in Chongqing, China were recruited. The mental health status was assessed using symptom checklist-90 (SCL-90).Results: Our sample was composed of 83 pregnant HCWs (mean age = 29.8) and 122 pregnant non-HCWs (mean age = 30.8). The results suggested the prevalence of psychological symptoms (the factor score ≥2) among all pregnant women ranged from 6.83% (psychosis symptoms) to 17.56% (obsessive-compulsive symptoms). Compared with pregnant non-HCWs, pregnant HCWs reported higher prevalence of psychological symptoms in 10 factors of SCL-90. After controlling the confounding variables, multiple logistic regression demonstrated that pregnant HCWs experienced higher prevalence of psychological symptoms of somatization (18.07 vs. 5.74%, p = 0.006, aOR = 4.52), anxiety disorders (16.87 vs. 6.56%, p = 0.016, aOR = 3.54), and hostility (24.10 vs. 10.66%, p = 0.027, aOR = 2.70) than those among pregnant non-HCW.Conclusion: Our study indicated that pregnant HCWs were more likely to suffer from mental health distress than pregnant non-HCWs during the early stage of COVID-19 pandemic. It is vital to implement targeted psychological interventions for pregnant women, especially for pregnant HCWs to cope with distress when facing the emerging infectious diseases.
The Association Between Internet Addiction and Anxiety in Nursing Students: A Network Analysis
Authors: Cai Hong , Xi Hai-Tao , An Fengrong , Wang Zhiwen , Han Lin , Liu Shuo , Zhu Qianqian , Bai Wei , Zhao Yan-Jie , Chen Li , Ge Zong-Mei , Ji Mengmeng , Zhang Hongyan , Yang Bing-Xiang , Chen Pan , Cheung Teris , Jackson Todd , Tang Yi-Lang , Xiang Yu-Tao 
Published: August 2021

Background: Nursing students who suffer from co-occurring anxiety experience added difficulties when communicating and interacting with others in a healthy, positive, and meaningful way. Previous studies have found strong positive correlations between Internet addiction (IA) and anxiety, suggesting that nursing students who report severe IA are susceptible to debilitating anxiety as well. To date, however, network analysis (NA) studies exploring the nature of association between individual symptoms of IA and anxiety have not been published.Objective: This study examined associations between symptoms of IA and anxiety among nursing students using network analysis.Methods: IA and anxiety symptoms were assessed using the Internet Addiction Test (IAT) and the Generalized Anxiety Disorder Screener (GAD-7), respectively. The structure of IA and anxiety symptoms was characterized using “Strength” as a centrality index in the symptom network. Network stability was tested using a case-dropping bootstrap procedure and a Network Comparison Test (NCT) was conducted to examine whether network characteristics differed on the basis of gender and by region of residence.Results: A total of 1,070 nursing students participated in the study. Network analysis showed that IAT nodes, “Academic decline due to Internet use,” “Depressed/moody/nervous only while being off-line,” “School grades suffer due to Internet use,” and “Others complain about your time spent online” were the most influential symptoms in the IA-anxiety network model. Gender and urban/rural residence did not significantly influence the overall network structure.Conclusion: Several influential individual symptoms including Academic declines due to Internet use, Depressed/moody/nervous only while being off-line, School grades suffering due to Internet use and Others complain about one's time spent online emerged as potential targets for clinical interventions to reduce co-occurring IA and anxiety. Additionally, the overall network structure provides a data-based hypothesis for explaining potential mechanisms that account for comorbid IA and anxiety.