bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlinear reconstruction of bioclimatic outdoor-environment dynamics for the Lower Silesia region (SW Poland)
Authors: Głogowski Arkadiusz , Perona Paolo , Bryś Krystyna , Bryś Tadeusz 
Published: March 2021

AbstractMeasured meteorological time series are frequently used to obtain information about climate dynamics. We use time series analysis and nonlinear system identification methods in order to assess outdoor-environment bioclimatic conditions starting from the analysis of long historical meteorological data records. We investigate and model the stochastic and deterministic properties of 117 years (1891–2007) of monthly measurements of air temperature, precipitation and sunshine duration by separating their slow and fast components of the dynamics. In particular, we reconstruct the trend behaviour at long terms by modelling its dynamics via a phase space dynamical systems approach. The long-term reconstruction method reveals that an underlying dynamical system would drive the trend behaviour of the meteorological variables and in turn of the calculated Universal Thermal Climatic Index (UTCI), as representative of bioclimatic conditions. At longer terms, the system would slowly be attracted to a limit cycle characterized by 50–60 years cycle fluctuations that is reminiscent of the Atlantic Multidecadal Oscillation (AMO). Because of lack of information about long historical wind speed data we performed a sensitivity analysis of the UTCI to three constant wind speed scenarios (i.e. 0.5, 1 and 5 m/s). This methodology may be transferred to model bioclimatic conditions of nearby regions lacking of measured data but experiencing similar climatic conditions.
Invariance under discretization for positive systems
Authors: Bartosiewicz Zbigniew 
Published: March 2021

AbstractPositive dynamical or control systems have all their variables nonnegative. Euler discretization transforms a continuous-time system into a system on a discrete time scale. Some structural properties of the system may be preserved by discretization, while other may be lost. Four fundamental properties of positive systems are studied in the context of discretization: positivity, positive stability, positive reachability and positive observability. Both linear and nonlinear systems are investigated.
Surgical treatment outcome after serial debridement of infected nonunion—A retrospective cohort study
Authors: Rupp Markus , Kern Stefanie , Walter Nike , Anastasopoulou Lydia , Schnettler Reinhard , Heiss Christian , Alt Volker 
Published: March 2021

Abstract
Purpose
Reported outcome after multiple staged surgical treatment of infected nonunion is scarce. We, therefore, asked: (1) What is the clinical outcome in infected nonunion patients after multiple staged revision surgery? (2) Are different pathogens evidenced after surgical treatment in patients who have undergone more or less surgeries?

Methods
All enrolled patients were surgically treated for long bone-infected nonunion between January 2010 and March 2018. Besides patients´ demographics outcome in terms of bony consolidation and major complications defined as death during inward treatment, amputation and recurrence of infection during follow-up of at least 12 months were assessed. Microbiological findings were assessed and compared between two groups with less than five versus five or more surgical revisions.

Results
Bone consolidation was achieved in 86% of the patients while complications such as femoral or transtibial amputation, recurrence of infection or even death during inpatient treatment could be evidenced in six patients (14%). In patients who underwent multiple-stage surgery for five or more times, germ changes and repeated germ detection was more common than in patients with less surgeries.

Conclusions
Surgical treatment of infected nonunions poses a high burden on the patients with major complications occurring in about 14% of the patients using a multiple staged treatment concept. Future prospective studies comparing outcomes after limited with multiple staged revision surgeries are necessary.
Cognitive dysfunction in amyotrophic lateral sclerosis: can we predict it?
Authors:   on behalf of SIgN, De Marchi Fabiola , Carrarini Claudia , De Martino Antonio , Diamanti Luca , Fasano Antonio , Lupica Antonino , Russo Mirella , Salemme Simone , Spinelli Edoardo Gioele , Bombaci Alessandro 
Published: March 2021

AbstractBackground and aimAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the degeneration of both upper and lower motoneurons in the brain and spinal cord leading to motor and extra-motor symptoms. Although traditionally considered a pure motor disease, recent evidences suggest that ALS is a multisystem disorder. Neuropsychological alterations, in fact, are observed in more than 50% of patients: while executive dysfunctions have been firstly identified, alterations in verbal fluency, behavior, and pragmatic and social cognition have also been described. Detecting and monitoring ALS cognitive and behavioral impairment even at early disease stages is likely to have staging and prognostic implications, and it may impact the enrollment in future clinical trials. During the last 10 years, humoral, radiological, neurophysiological, and genetic biomarkers have been reported in ALS, and some of them seem to potentially correlate to cognitive and behavioral impairment of patients. In this review, we sought to give an up-to-date state of the art of neuropsychological alterations in ALS: we will describe tests used to detect cognitive and behavioral impairment, and we will focus on promising non-invasive biomarkers to detect pre-clinical cognitive decline.ConclusionsTo date, the research on humoral, radiological, neurophysiological, and genetic correlates of neuropsychological alterations is at the early stage, and no conclusive longitudinal data have been published. Further and longitudinal studies on easily accessible and quantifiable biomarkers are needed to clarify the time course and the evolution of cognitive and behavioral impairments of ALS patients.
Gender differences in time to first hospital admission at age 60 in Denmark, 1995–2014
Authors: Höhn Andreas , Oksuzyan Anna , Lindahl-Jacobsen Rune , Christensen Kaare , Seaman Rosie 
Published: March 2021

AbstractWomen have consistently lower mortality rates than men at all ages and with respect to most causes. However, gender differences regarding hospital admission rates are more mixed, varying across ages and causes. A number of intuitive metrics have previously been used to explore changes in hospital admissions over time, but have not explicitly quantified the gender gap or estimated the cumulative contribution from cause-specific admission rates. Using register data for the total Danish population between 1995 and 2014, we estimated the time to first hospital admission for Danish men and women aged 60. This is an intuitive population-level metric with the same interpretive and mathematical properties as period life expectancy. Using a decomposition approach, we were able to quantify the cumulative contributions from eight causes of hospital admission to the gender gap in time to first hospital admission. Between 1995 and 2014, time to first admission increased for both, men (7.6 to 9.4 years) and women (8.3 to 10.3 years). However, the magnitude of gender differences in time to first admission remained relatively stable within this time period (0.7 years in 1995, 0.9 years in 2014). After age 60, Danish men had consistently higher rates of admission for cardiovascular conditions and neoplasms, but lower rates of admission for injuries, musculoskeletal disorders, and sex-specific causes. Although admission rates for both genders have generally declined over the last decades, the same major causes of admission accounted for the gender gap. Persistent gender differences in causes of admission are, therefore, important to consider when planning the delivery of health care in times of population ageing.
Effects of experimental warming on small phytoplankton, bacteria and viruses in autumn in the Mediterranean coastal Thau Lagoon
Authors: Courboulès Justine , Vidussi Francesca , Soulié Tanguy , Mas Sébastien , Pecqueur David , Mostajir Behzad 
Published: March 2021

AbstractTo investigate the responses of a natural microbial plankton community of coastal Mediterranean waters to warming, which are still poorly known, an in situ mesocosm experiment was carried out in Thau Lagoon during autumn 2018. Several microorganisms, including virio-, bacterio-, and phytoplankton < 10 µm in size, were monitored daily and analysed using flow cytometry for 19 consecutive days in six mesocosms. Three mesocosms (control) had the same natural water temperature as the lagoon, and the other three were warmed by + 3 °C in relation to the control temperature. The cytometric analyses revealed an unexpected community dominated by picophytoplanktonic cells, including Prochlorococcus-like and Picochlorum-like cells, which had not previously been found in Thau Lagoon. The experimental warming treatment increased the abundances of nanophytoplankton, cyanobacteria, bacteria and viruses during the experiment and triggered earlier blooms of cyanobacteria and picoeukaryotes. Only the abundance of Picochlorum-like cells was significantly reduced under warmer conditions. The growth and grazing rates of phytoplankton and bacterioplankton estimated on days 2 and 8 showed that warming enhanced the growth rates of most phytoplankton groups, while it reduced those of bacteria. Surprisingly, warming decreased grazing on phytoplankton and bacteria at the beginning of the experiment, while during the middle of the experiment it decreased the grazing on prokaryote only but increased it for eukaryotes. These results reveal that warming affected the Thau Lagoon plankton community from viruses to nanophytoplankton in fall, inducing changes in both dynamics and metabolic rates.
A first-in-human phase I study of TAS0728, an oral covalent binding inhibitor of HER2, in patients with advanced solid tumors with HER2 or HER3 aberrations
Authors: Piha-Paul Sarina A. , Azaro Analía , Arkenau Hendrik Tobias , Oh Do-Youn , Galsky Matthew D. , Pal Sumanta Kumar , Hamada Kensuke , He Yaohua , Yamamiya Ikuo , Benhadji Karim A , Hollebecque Antoine 
Published: March 2021

SummaryTAS0728 is an oral covalent binding inhibitor of human epidermal growth factor receptor 2 (HER2). A first-in-human open-label, dose-escalation, phase I study (NCT03410927) was initiated to investigate the safety and dose-limiting toxicity (DLT) and to determine the maximum tolerated dose (MTD) and/or recommended phase II dose of TAS0728 in adults with advanced solid tumors with HER2 or HER3 overexpression, amplification or mutation. In total, 19 patients received TAS0728 at escalating doses from 50 to 200 mg BID for 21-day cycles. Following escalation of the dose to 200 mg BID, a total of two DLTs were observed, both cases of Grade 3 diarrhea (lasting >48 h and not responsive to aggressive antidiarrheal treatment). Following de-escalation of the dose to 150 mg BID, another DLT of Grade 3 diarrhea was observed in one patient. Additionally, at 150 mg BID, one patient had a fatal cardiac arrest after receiving 1 cycle (21 days) of TAS0728. The etiology of the cardiac arrest event was not clear, however causal relationship to TAS0728 could not be excluded due to the temporal association observed. Partial responses were observed in 2 of 14 patients evaluable for TAS0728 treatment response. The study was stopped due to unacceptable toxicity during the dose-escalation as the overall risk-benefit ratio no longer favored the dose level being tested, therefore the MTD was not determined. ClinicalTrials.gov registration number: https://clinicaltrials.gov/ct2/show/NCT03410927; registered on January 25, 2018.
Teachers’ conceptual understanding of fraction operations: results from a national sample of elementary school teachers
Authors: Copur-Gencturk Yasemin 
Published: March 2021

AbstractTeachers’ understanding of the concepts they teach affects the quality of instruction and students’ learning. This study used a sample of 303 teachers from across the USA to examine elementary school mathematics teachers’ knowledge of key concepts underlying fraction arithmetic. Teachers’ explanations were coded based on the accuracy of their explanations and the kinds of concepts and representations they used in their responses. The results showed that teachers’ understanding of fraction arithmetic was limited, especially for fraction division, yet a moderate relationship was found between teachers’ understanding of fraction addition and division. Furthermore, more experienced teachers seemed to have a deeper understanding of fraction arithmetic, whereas special education teachers had a substantially limited understanding.
Give me a challenge or give me a raise
Authors: Alekseev Aleksandr 
Published: March 2021

AbstractI study the effect of task difficulty on workers’ effort. I find that task difficulty has an inverse-U effect on effort and that this effect is quantitatively large, especially when compared to the effect of conditional monetary rewards. Difficulty acts as a mediator of monetary rewards: conditional rewards are most effective at the intermediate or high levels of difficulty. The inverse-U pattern of effort response to difficulty is inconsistent with many popular models in the literature, including the Expected Utility models with the additively separable cost of effort. I propose an alternative mechanism for the observed behavior based on non-linear probability weighting. I structurally estimate the proposed model and find that it successfully captures the behavioral patterns observed in the data. I discuss the implications of my findings for the design of optimal incentive schemes for workers and for the models of effort provision.
Legal Translation Versus Legal Interpretation. A Legal-Theoretical Perspective
Authors: Zeifert Mateusz , Tobor Zygmunt 
Published: March 2021

AbstractIn this article we investigate the relationship between legal translation and legal interpretation. The common wisdom is that these activities are closely related, but the nature of that relationship remains disputable. We adopt the perspective of legal theory—as opposed to the perspective of translation studies—which seems to be underrepresented in the literature of the subject. We start with distinguishing between the two notions of legal interpretation: the wide sense (interpretation as understanding) and the narrow sense (interpretation as problem solving). We argue that the relationship between legal translation and legal interpretation changes significantly depending on the notion of legal interpretation that is assumed. The wide sense is often assumed by translation scholars and it renders legal interpretation as a necessary prerequisite for legal translation. Jurists, on the other hand, usually assume the narrow sense which renders legal interpretation and legal translation as two distinct activities with some shared features. We then focus on four issues of legal interpretation in the narrow sense: the types of legal interpretive problems, the creation of legal interpretive problems, the methods of legal interpretation, the resolution of legal interpretive problems. We conclude with a detailed comparison of legal translation and legal interpretation in the context of those four issues.
A New Measure of 19th Century US Suicides
Authors: Kronenberg Christoph 
Published: March 2021

AbstractSuicides hurt families and the US economy with an annual cost of $69 billion. However, little is known about what determined suicide rates in the past. This is likely due to the lack of consistent data prior to the 20th century. In this article, I propose using newspaper suicide mentions for the period 1840–1910 as a proxy measure for suicide and perform several validation exercises. I show that the stylized facts like suicides drop during wars holds for suicide mentions. I also validate the newspaper suicide mentions against sparse suicide mortality data and a novel valence measure. This new measure can be used to assess the relationship between suicides and numerous policy changes happening in the 19th century that previously could not be explored. It thus offers a new research avenue for quantitative historical analyses, which can inform current policy via novel historical insights.
Does the combining effects of energy and consideration of financial development lead to environmental burden: social perspective of energy finance?
Authors: Chien Fengsheng , Chau Ka Yin , Ady Sri Utami , Zhang YunQian , Tran Quyen Ha , Aldeehani Talla M. 
Published: March 2021

AbstractIn light of the rapidly growing industrialization in BRICS and G7 regions, thorough energy, financials, and environmental analyses are essential for sustainable financial development in these countries. In this context, this work analyzes the relationship between energy, financial, and environmental sustainability and the regions’ social performance. Data from 2000 to 2017 is analyzed through a data envelopment analysis (DEA) like a composite index. Results show China and Brazil’s better performance in the region, with a sustainability score of 0.96, India was the third, followed by South Africa and Russia. Japan, the UK, and the USA were the most energy-efficient countries for five consecutive years. A 0.18%, 0.27%, 0.22%, 0.09%, 0.31%, and 0.32% reduction in carbon emission is observed with a 1% increase in R&D costs by Canada, France, Germany, Italy, Japan, and the USA, respectively. This work contributes to the existing literature regarding an eco-friendly sustainable policy design for the G7 countries based on multiple indicators.
Are children’s judgments of another’s accuracy linked to their metacognitive confidence judgments?
Authors: Baer Carolyn , Malik Puja , Odic Darko 
Published: March 2021

AbstractThe world can be a confusing place, which leads to a significant challenge: how do we figure out what is true? To accomplish this, children possess two relevant skills: reasoning about the likelihood of their own accuracy (metacognitive confidence) and reasoning about the likelihood of others’ accuracy (mindreading). Guided by Signal Detection Theory and Simulation Theory, we examine whether these two self- and other-oriented skills are one in the same, relying on a single cognitive process. Specifically, Signal Detection Theory proposes that confidence in a decision is purely derived from the imprecision of that decision, predicting a tight correlation between decision accuracy and confidence. Simulation Theory further proposes that children attribute their own cognitive experience to others when reasoning socially. Together, these theories predict that children’s self and other reasoning should be highly correlated and dependent on decision accuracy. In four studies (N = 374), children aged 4–7 completed a confidence reasoning task and selective social learning task each designed to eliminate confounding language and response biases, enabling us to isolate the unique correlation between self and other reasoning. However, in three of the four studies, we did not find that individual differences on the two tasks correlated, nor that decision accuracy explained performance. These findings suggest self and other reasoning are either independent in childhood, or the result of a single process that operates differently for self and others.
A Mathematical Model Supporting a Hyperpredation Effect in the Apparent Competition Between Invasive Eastern Cottontail and Native European Hare
Authors: Caudera Elisa , Viale Simona , Bertolino Sandro , Cerri Jacopo , Venturino Ezio 
Published: March 2021

AbstractIn this work a mathematical model is built in order to validate on theoretical grounds field study results on a three-species system made of two prey, of which one is native and another one invasive, together with a native predator. Specifically, our results mathematically describe the negative effect on the native European hare after the introduction of the invasive Eastern cottontail, mediated by an increased predation rate by foxes. Two nonexclusive assumptions can be made: an increase in cottontail abundance would lead to a larger fox population, magnifying their predatory impact (“hyperpredation”) on hares; alternatively, cottontails attract foxes in patches where they live, which are also important resting sites for hares and consequently the increased presence of foxes results in a higher predation rates on hares. The model results support hyperpredation of increasing fox populations on native hares.
Asymptomatic systolic dysfunction on contemporary echocardiography in anthracycline-treated long-term childhood cancer survivors: a systematic review
Authors: Merkx Remy , Leerink Jan M. , de Baat Esmée C. , Feijen Elizabeth A. M. , Kok Wouter E. M. , Mavinkurve-Groothuis Annelies M. C. , Loonen Jacqueline , van der Pal Helena J. H. , Bellersen Louise , de Korte Chris L. , Kremer Leontien C. M. , van Dalen Elvira C. , Kapusta Livia 
Published: March 2021

Abstract
Purpose
Echocardiographic surveillance for asymptomatic left ventricular systolic dysfunction (ALVSD) is advised in childhood cancer survivors (CCS), because of their risk of heart failure after anthracycline treatment. ALVSD can be assessed with different echocardiographic parameters. We systematically reviewed the prevalence and risk factors of late ALVSD, as defined by contemporary and more traditional echocardiographic parameters.

Methods
We searched databases from 2001 to 2020 for studies on ≥ 100 asymptomatic 5-year CCS treated with anthracyclines, with or without radiotherapy involving the heart region. Outcomes of interest were prevalence of ALVSD—measured with volumetric methods (ejection fraction; LVEF), myocardial strain, or linear methods (fractional shortening; FS)—and its risk factors from multivariable analyses.

Results
Eleven included studies represented 3840 CCS. All studies had methodological limitations. An LVEF < 50% was observed in three studies in 1–6% of CCS, and reduced global longitudinal strain (GLS) was reported in three studies in 9–30% of CCS, both after a median follow-up of 9 to 23 years. GLS was abnormal in 20–28% of subjects with normal LVEF. Abnormal FS was reported in six studies in 0.3–30% of CCS, defined with various cut-off values (< 25 to < 30%), at a median follow-up of 10 to 18 years. Across echocardiographic parameters, reported risk factors were cumulative anthracycline dose and radiotherapy involving the heart region, with no ‘safe’ dose for ALVSD.

Conclusions
GLS identifies higher prevalence of ALVSD in anthracycline-treated CCS, than LVEF.

Implications for Cancer Survivors
The diagnostic and prognostic value of GLS should be evaluated within large cohorts.

Protocol registration
PROSPERO CRD42019126588