bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Sanitasi Dasar dengan Kejadian Diare pada Balita Di Wilayah Kerja Puskesmas Pembina Kota Palembang
Authors: Endawati Apriani , Sitorus Rico Januar , Listiono Heru 
Published: March 2021

Diarrhea was the number one case of death in baby 31.4%, childhood 25% and The fourth in all age groups 13.2%. South Sumatera precisely in Seberang Ulu II is a sub district that has highest rate of diarrhea disease one of the located in the working of Pembina health center were have that 979 cases. The purpose of this study was to association basic of sanitation (toilet quality, lay-stall and waste water disposal) related the incidence of diarrhea on childhood. This Research use propositional stratified accidental sampling (cross sectional) study design. The sample was mother that has children under five years old (0-59 month) and their were 52 respondent. The data analysis that was done bivariate and univariate data. Bivariate analysis used Chi square test. The result showed that there was significant correlation between toilet quality (ρ value 0.004 ; OR 7; 95% Cl 2.012-24.358), laystall (ρ value 0.000;OR 13; 95% Cl 3,005-56,236) and waste water disposal (ρ value 0.000; OR 15,75; 95% Cl 3,601- 68,884) with diarrhea childhood. The conclusion that the distribution of the incidence of diarrhea was 15,75% and from all variable there was significant correlation with diarrhea in childhood. We suggest making latrines/toilet, constructing a simple covered garbage dumps and repair or making waste water disposal and optimizing environmental health socialization programs, namely prevention and control of disease.
Gambaran Efikasi Diri Pasien yang Menjalani Hemodialisis
Authors: Lenggogeni Devia Putri , Malini Hema , Fatmadona Rika , Roza Ega Silvia 
Published: March 2021

Self-efficacy is an individual's perception of their ability in carrying out of action. Self- efficacy is required by end-stage renal disease patients undergoing hemodialysis to be able to carry out good self-management. This research was using a descriptive design. The number of samples used in this study amounted to 63 people. Sampling was done by consecutive sampling technique. Data was collected by using Chronic Kidney Disease Self Efficacy (CKD-SE) questionnaire. Based on this study was known that the largest age range is 41-60 years (66,7%), the most respondent is male (60.3%), the most respondent is still working (61.9%), the most etiology of end stage renal disease is hypertensive renal disease (52.4%), the highest education of respondents is senior high school (47.6%), duration hemodialysis is < 12 months (71.4%). The mean score of self-efficacy was 72.25. The highest sub-variable of self-efficacy is autonomy which a mean score 23.51. Self-efficacy assessment using CKD-SE can be used in patients undergoing hemodialysis. Knowing self-efficacy can help a nurse to educate patients, so that will improve self-management patients undergoing hemodialysis.
REPLAY: It’s March 11th. Let’s try to fight Covid differently. How would you do it?
Authors: Jain Shrey 
Published: March 2021

Suppose you have the ability to go back to March 11th of 2020 - the date the WHO officially declared COVID-19 a pandemic1.
What could have been done differently with respect to digital health product development?
Were domain experts utilized to the best of their abilities? What can we learn from COVID-19 for future public health crises planning?
Digital health data is now, more than ever, deeply influencing our lives. Having robust digital health tools to support public health surveillance is no longer a problem for technocrats.
It’s everyone’s business now.
Through the COVID-19 pandemic, I had the opportunity to lead a digital health startup, Flatten.ca, that focused on collecting symptom data from people in Canada and in Somalia2. This experience led to collaborations with big-tech companies, researchers, government officials, startups, and investors.
Reflecting back on my experiences, I see many flaws in the process by which the North-American community decided to develop and deploy digital health tools. Simply put, a lack of speed and strategically allocated domain expertise hindered our success. Why did Canada take 5 months to launch a contact tracing app and Singapore only 10 days?
This perspective piece aims at answering the questions highlighted above and analyzing the North-American response to build digital health tools as the COVID-19 pandemic rages on. Whether you’re an investor, academic, student, founder, or otherwise involved in the digital health industry, and you’re thinking about how to effectively support product development for future public health crises, this can help better inform where your efforts are best spent.
Planting System Effects on Intercropping of Gardenpea and Sorghum
Authors: Begum AA , Mian MAK , Kamal SMAHM , Karim MR , Saha RR , Hossain MA 
Published: March 2021

The field experiment was conducted at Agronomy Research Field, Joydebpur and RARS, Burirhat, Rangpur, BARI during Rabi season of 2018-2019 and 2019-2020 to find out suitable combination of sorghum and gardenpea intercropping for higher productivity and monetary advantage. Treatments included in the experiment were: T1 = Sorghum normal row (SNR) + 1 row gardenpea (GP), T2 = SNR + 2 rows GP, T3 = Sorghum paired row (SPR) + 2 rows GP, T4 = SPR + 3 rows GP, T5 = SPR + 4 rows GP, T6 = Sole sorghum (60 cm ´ 10 cm) and T7 = Sole GP (30 cm ´ 10 cm). Light availability on gardenpea decreased with the increase of shade produced by sorghum canopy over the time up to 60 DAS. The lowest light availability on gardenpea was observed in T2 treatment and the highest was observed in sole gardenpea (T7) followed by T3 treatment in both the years. The maximum grain yield of sorghum was observed in T6 and it was decreased (6-10% in 2018-2019 and 1-12% in 2019-2020) at Joydebpur and (5-11% in 2018-2019 and 6-14% in 2019-2020) at Burirhat. The highest sorghum equivalent yield (SEY) of 10.93 t ha-1 in 2018-2019 and 12.02 t ha-1 in 2019-2020 at Joydebpur and 12.06 t ha-1 in 2018-2019 and 11.77 t ha-1 in 2019-2020 at Burirhat and also the highest land equivalent ratio (LER) of 1.77 in 2018-2019 and 1.93 in 2019-2020 at Joydebpur and 1.79 in 2018-2019 and 1.81 in 2019-2020 at Burirhatwere observed in T5 treatment. The highest gross margin of Tk.146600 ha-1 in 2018-2019 and Tk.168400 ha-1 in 2019-2020 at Joydebpur and Tk. 169200 ha-1 in 2018-2019 and Tk.163400 ha-1 in 2019-2020 at Burirhat and also the benefit cost ratio (BCR) of 3.04 in 2018-2019 and 3.34 in 2019-2020 at Joydebpur and 3.35 in 2018-2019 and 3.27 in 2019-2020 at Burirhat were also found in the same treatment. The results revealed that sorghum paired row + 4 rows gardenpea might be agronomically feasible and economically profitable for sorghum + gardenpea intercropping system at Joydebpur and Burirhat region.
Bangladesh Agron. J. 2020, 23(2): 59-68
PENERAPAN SISTEM EMULSI MEMBRAN TERHADAP KONTROL AIR TAMBAK DAN SISTEM IJUK TERHADAP PENYEDIAAN AIR BERSIH DI BUMI DIPASENA
Authors: Harefa Nelius , - Setiyadi , Tampubolon Sudarno , Naibaho Lamhot 
Published: March 2021

Abstrak
Pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pemahaman dan kesadaran masyarakat serta sebagai mediator dalam menyelesaikan masalah penurunan hasil panen udang dan ketersediaan air bersih di Bumi Dipasena. Hasil panen udang masyarakat berada dibawah standar dan sangat jauh berbeda dibanding hasil panen perusahaan. Ketersediaan air bersih mengandalkan air hujan yang memiliki batas waktu layak pakai dan menjadi barang langka dimusim kemarau. Kedua permasalahan tersebut menjadi permasalahan utama dan belum terselesaikan selama bertahun-tahun. Banyak alasan yang menjadi penyebab tidak terselesaikannya masalah, mulai dari biaya, tidak adanya kolaborasi antar masyarakat, dan lain sebagainya. Oleh sebab itu, mereka membutuhkan solusi yang tidak hanya tepat guna namun dapat mengakomodasi kepentingan masyarakat. Maka, alternatif solusi permasalahan penurunan hasil panen udang yang disarankan adalah pengontrolan air tambak udang masyarakat dengan menggunakan sistem emulsi membran dan penyediaan air bersih menggunakan sistem ijuk. Kedua solusi tersebut diyakini dapat terealisasi karena terjangkau dari sisi biaya, sistem kontrol tidak kompleks, dan bahan dasar pembuatan sistem dihasilkan oleh masyarakat sendiri. Alasan tersebut menstimulus masyarakat untuk antusias dalam merespon kedua sistem yang ditawarkan dan menginginkan supaya sistem tersebut direalisasikan.
Kata Kunci: Sistem Emulsi Membran; Sistem Ijuk

Abstract
This community service aims to increase people's understanding and awareness as well as a mediator in resolving the problem of decreasing shrimp yields and the availability of clean water on Bumi Dipasena. Community shrimp yields are below the standard and very much different from the company's harvest. The availability of clean water relies on rainwater which has a time limit for proper use and is a rare item in the dry season. Both of these problems have become major problems and have not been resolved for years. Many reasons are the cause of unresolved problems, starting from costs, the absence of collaboration between communities, and etc. Therefore, they need solutions that are not only effective but can accommodate the interests of the community. So, the alternative solution to the problem of decreasing shrimp yields suggested is the control of community shrimp farm water using a membrane emulsion system and the provision of clean water using a palm fiber system. The two solutions are believed to be realized because they are affordable in terms of costs, the control system is not complex, and the basic material for making the system is produced by the community itself. The reason stimulates the community to be enthusiastic in responding to the two systems offered and wants the system to be realized.
Keywords: Membrane Emulsion System, Palm Fiber System
Assessment of 10-Year Left-Ventricular-Remodeling by CMR in Patients Following Aortic Valve Replacement
Authors: Rank Nina , Stoiber Lukas , Nasser Mithal , Tanacli Radu , Stehning Christian , Knierim Jan , Schoenrath Felix , Pieske Burkert , Falk Volkmar , Kuehne Titus , Meyer Alexander , Kelle Sebastian 
Published: March 2021

Aims: Aortic valve replacement (AVR) may result in reverse cardiac remodeling. We aimed to assess long-term changes in the myocardium following AVR by Cardiac Magnetic Resonance Imaging (CMR).Methods: We prospectively observed the long-term left ventricular (LV) function and structure of 27 patients with AVR [n = 19 with aortic stenosis (AS); n = 8 with aortic regurgitation (AR)] by CMR. Patients underwent CMR before, as well as 1, 5, and 10 years after AVR. We evaluated clinical parameters, LV volumes, mass, geometry, ejection fraction (EF), global myocardial longitudinal strain (MyoGLS), global myocardial circular strain (MyoGCS), hemodynamic forces (HemForces), and Late Gadolinium Enhancement (LGE).Results: The median of LVMI, EDVI, and ESVI decreased in both groups. Patients with AR had higher initial values of EDVI and ESVI and showed a more prominent initial reduction. In AS, MyoGLS improved already after 1 year and remained constant afterward, whereas, in AR no improvement of MyoGLS was found. MyoGCS remained unchanged in the AS group but deteriorated in the AR group over 10 years. Ejection fraction (EF) was higher in AS patients compared to AR 10 years post-AVR. Late gadolinium enhancement (LGE) could be found more frequently in AS patients.Conclusion: CMR was well suited to investigate myocardial changes over a 10-year follow up period in patients with aortic valve disease. Regarding the long-term functional changes following AVR, patients with AR seemed to benefit less from AVR compared to AS patients. Fibrosis was more common in AS, but this did not reflect functional evolution in these patients. Close monitoring seems indispensable to avoid irreversible structural damage of the heart and to perform AVR at an appropriate stage.
Case Report: A Case of Pituitary Adenoma Producing Growth Hormone and Thyroid-Stimulating Hormone Simultaneously
Authors: Sanada Junpei , Tatsumi Fuminori , Kamei Shinji , Fushimi Yoshiro , Shimoda Masashi , Kohara Kenji , Nakanishi Shuhei , Kaku Kohei , Mune Tomoatsu , Kaneto Hideaki 
Published: March 2021

BackgroundPituitary adenoma producing growth hormone (GH) or thyroid-stimulating hormone (TSH) is characterized by various specific symptoms and/or findings. However, the frequency of pituitary adenoma producing both hormones is relatively low. In this report, we show a case of pituitary adenoma producing both GH and TSH simultaneously.Case presentationA 27-year-old woman was diagnosed as acromegaly based on various symptoms and clinical findings. For further examination and treatment, she was hospitalized in our institution. It was likely that this subject had pituitary adenoma producing both GH and TSH. In brain magnetic resonance imaging, there was a giant tumor around pituitary fossa. After the diagnosis of GH- and TSH-producing pituitary adenoma, pituitary tumor resection and cyber knife therapy were performed. In addition, we started additional treatment with somatostatin analog and GH receptor antagonist. After then, GH and insulin-like growth factor (IGF-1) levels were suppressed. After the operation, since thyroid function was not sufficiently suppressed, we started anti-thyroid drug thiamazole. After then, thyroid function was normalized and we stopped thiamazole. In GH and TSH staining, many GH-positive and TSH-positive cells were observed. These findings further confirmed our diagnosis that the pituitary adenoma in this subject produced both GH and TSH simultaneously.ConclusionsWe should bear in mind the possibility of pituitary adenoma producing both GH and TSH at the same time.
Preparation and Absorption Carbon Monoxide Properties of a Novel Flame Retardants Based Fire-Fighting Foam
Authors: Li Xiujuan , Guo Ruisong , Qian Xiaodong 
Published: March 2021

The toxicity of CO threatens the life of people in the fire site. In this study, flame retardants of nano magnesium hydroxide particles and water-soluble flame retardant 8124 are used to be mixed into the aqueous film forming fire extinguishing agent (AFFF). Smoke-suppressed fire extinguishing agent was prepared in Waring-Blender mixing cup and then stirred at 3,000 r/min for 5 min. The new extinguishing agent shows a good performance of absorption of CO and reducing the flue gas temperature. The concentration of CO was decreased below 131 ppm and flue gas temperature was basically kept below 40°C, which was 367 ppm and 83.1°C less than that in free-fire. Using new extinguishing agent can effectively reduce the harm to the trapped personnel and firemen in the fire site. It was of great significance. The harm of CO concentration below 131 ppm and flue gas temperature below 40°C was low. The time to reach the maximum CO concentration and the maximum flue gas temperature was delayed, which ensures that people have more time to escape. Even if there was not enough time to escape, people will not be seriously threatened.
Gut-Derived Metabolite Indole-3-Propionic Acid Modulates Mitochondrial Function in Cardiomyocytes and Alters Cardiac Function
Authors: Gesper Maren , Nonnast Alena B. H. , Kumowski Nina , Stoehr Robert , Schuett Katharina , Marx Nikolaus , Kappel Ben A. 
Published: March 2021

Background: The gut microbiome has been linked to the onset of cardiometabolic diseases, in part facilitated through gut microbiota-dependent metabolites such as trimethylamine-N-oxide. However, molecular pathways associated to heart failure mediated by microbial metabolites remain largely elusive. Mitochondria play a pivotal role in cellular energy metabolism and mitochondrial dysfunction has been associated to heart failure pathogenesis. Aim of the current study was to evaluate the impact of gut-derived metabolites on mitochondrial function in cardiomyocytes via an in vitro screening approach.Methods: Based on a systematic Medline research, 25 microbial metabolites were identified and screened for their metabolic impact with a focus on mitochondrial respiration in HL-1 cardiomyocytes. Oxygen consumption rate in response to different modulators of the respiratory chain were measured by a live-cell metabolic assay platform. For one of the identified metabolites, indole-3-propionic acid, studies on specific mitochondrial complexes, cytochrome c, fatty acid oxidation, mitochondrial membrane potential, and reactive oxygen species production were performed. Mitochondrial function in response to this metabolite was further tested in human hepatic and endothelial cells. Additionally, the effect of indole-3-propionic acid on cardiac function was studied in isolated perfused hearts of C57BL/6J mice.Results: Among the metabolites examined, microbial tryptophan derivative indole-3-propionic acid could be identified as a modulator of mitochondrial function in cardiomyocytes. While acute treatment induced enhancement of maximal mitochondrial respiration (+21.5 ± 7.8%, p &lt; 0.05), chronic exposure led to mitochondrial dysfunction (−18.9 ± 9.1%; p &lt; 0.001) in cardiomyocytes. The latter effect of indole-3-propionic acids could also be observed in human hepatic and endothelial cells. In isolated perfused mouse hearts, indole-3-propionic acid was dose-dependently able to improve cardiac contractility from +26.8 ± 11.6% (p &lt; 0.05) at 1 μM up to +93.6 ± 14.4% (p &lt; 0.001) at 100 μM. Our mechanistic studies on indole-3-propionic acids suggest potential involvement of fatty acid oxidation in HL-1 cardiomyocytes.Conclusion: Our data indicate a direct impact of microbial metabolites on cardiac physiology. Gut-derived metabolite indole-3-propionic acid was identified as mitochondrial modulator in cardiomyocytes and altered cardiac function in an ex vivo mouse model.
Detection of EGFR Mutations in Cerebrospinal Fluid of EGFR-Mutant Lung Adenocarcinoma With Brain Metastases
Authors: Shi Liang , Tang Junfang , Tao Hong , Guo Lili , Wu Weihua , Wu Hongbo , Liu Zichen , Tong Li , Wu Wei , Li Hongxia , Meng Qiyi , Xu Liyan , Che Nanying , Liu Zhe 
Published: March 2021

BackgroundWe aimed to investigate the feasibility of detecting epidermal growth factor receptor (EGFR) mutations in cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) and plasma of advanced lung adenocarcinoma (LADC) with brain metastases (BMs) by droplet digital polymerase chain reaction (ddPCR).MethodsThirty advanced LADC patients with BMs were enrolled, and their matched CSF and plasma samples were collected. Droplet digital PCR was used to test cfDNA in CSF and plasma for EGFR mutation status. The clinical response and prognosis were evaluated.ResultsOut of 30 patients, there were 21 females and 9 males, aged 34-75 years. In all of the cases, CSF cytology were negative. In ddPCR assays, 10 patients (33.3%) had EGFR mutation in CSF, including 3 cases of EGFR T790M mutation, and 16 patients (53.3%) had EGFR mutation in plasma, including 6 cases of EGFR T790M mutation. Five patients with activating EGFR mutations in CSF achieved an intracranial partial response (iPR) after combination treatment with the first-generation EGFR-tyrosine kinase inhibitors. Three patients with EGFR T790M mutations in CSF achieved iPR after second-line osimertinib treatment. The median overall survival and intracranial progression-free survival were 17.0 months and 11.0 months, respectively.ConclusionIt was feasible to test EGFR mutation in cerebrospinal fluid and plasma. In LADC patients with brain metastasis, cerebrospinal fluid can be used as a liquid biopsy specimen to guide treatment strategy by monitoring EGFR mutation status.
An Inflammatory Response-Related Gene Signature Can Impact the Immune Status and Predict the Prognosis of Hepatocellular Carcinoma
Authors: Lin Zhuo , Xu Qian , Miao Dan , Yu Fujun 
Published: March 2021

BackgroundHepatocellular carcinoma (HCC) is a highly heterogeneous disease, which makes the prognostic prediction challenging. As part of the active cross-talk between the tumor and the host, inflammatory response in the tumor or its microenvironment could affect prognosis. However, the prognostic value of inflammatory response-related genes in HCC remains to be further elucidated.MethodsIn this study, the mRNA expression profiles and corresponding clinical data of HCC patients were downloaded from the public database. The least absolute shrinkage and selection operator Cox analysis was utilized to construct a multigene prognostic signature in the TCGA cohort. HCC patients from the ICGC cohort were used for validation. Kaplan Meier analysis was used to compare the overall survival (OS) between high- and low-risk groups. Univariate and multivariate Cox analyses were applied to determine the independent predictors for OS. Single-sample gene set enrichment analysis was utilized to calculate the immune cell infiltration score and immune related pathway activity. Gene set enrichment analysis was implemented to conduct GO terms and KEGG pathways. The qRT-PCR and immunohistochemistry were utilized to perform the mRNA and protein expression of prognostic genes between HCC tissues and normal liver tissues respectively.ResultsAn inflammatory response-related gene signature model was constructed by LASSO Cox regression analysis. Compared with the low-risk group, patients in the high-risk group showed significantly reduced OS. Receiver operating characteristic curve analysis confirmed the predictive capacity of the prognostic gene signature. Multivariate Cox analysis revealed that the risk score was an independent predictor for OS. Functional analysis indicated that immune status was definitely different between two risk groups, and cancer-related pathways were enriched in high-risk group. The risk score was significantly correlated with tumor grade, tumor stage and immune infiltrate types. The expression levels of prognostic genes were significantly correlated with sensitivity of cancer cells to anti-tumor drugs. Furthermore, the expression of prognostic genes showed significant difference between HCC tissues and adjacent non-tumorous tissues in the separate sample cohort.ConclusionA novel signature constructed with eight inflammatory response-related genes can be used for prognostic prediction and impact the immune status in HCC. Moreover, inhibition of these genes may be a therapeutic alternative.