bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testing the contribution of fibrinogen like 1 to the pathogenesis of metabolic dysfunction associated steatotic liver disease and hepatocellular carcinoma
Authors: Personnaz Jean , Cannizzo Lisa , Martin Céline Marie Pauline , Desquesnes Aurore , Sotin Manon , DaSilva Joanna , Guillou Hervé , Kautz Léon 
Published: December 2024

AbstractMetabolic dysfunction associated steatotic liver disease (MASLD) initiates from a simple steatosis that can evolve into hepatocellular carcinoma (HCC). The pathogensis of MASLD alters the secretion of hepatokines such as fibrinogen-like 1 (FGL1), a candidate mediator of liver steatosis and hyperglycemia. To investigate the contribution of FGL1 to liver diseases, we compared wild-type mice to mice with hepatocyte specific deletion ofFgl1subjected to a steatosis or HCC experimental protocol. We found that mice deficient forFgl1in hepatocytes showed a reduced tolerance to glucose with pronounced metabolic alterations and liver injury when fed a western diet compared to their wild-type counterparts. However, both genotypes exhibited a similar lipid deposition in the liver. Similarly, wild type andFgl1deficient mice displayed comparable liver alterations during HCC progression. We observed thatFGL1expression was repressed during MASLD progression in mice and human concomitantly with the severity of liver injury. Altogether, these findings suggest that FGL1 is not a major contributor to the pathogenesis of MASLD and HCC.
A self-limiting Sterile Insect Technique alternative forCeratitis capitata
Authors: Davydova Serafima , Liu Junru , Liu Yiran , Prince Kavya , Mann Jonathan , Kandul Nikolay P. , Braswell W. Evan , Champer Jackson , Akbari Omar S. , Meccariello Angela 
Published: December 2024

AbstractGenetic biocontrol systems have broad applications in population control of insects implicated in both disease spread and food security. In this study we establish and characterise a novel split-CRISPR/Cas9 system we term Sex Conversion Induced by CRISPR (SCIC) inCeratitis capitata(the Mediterranean fruit fly), a major agricultural pest with a global distribution. Using thewhite eyegene for toolkit selection, we achieved up to 100% CRISPR/Cas9 efficiency, displaying the feasibility ofC. capitatasplit-CRISPR/Cas9 systems using constitutive promoters. We then induce sex-conversion by targeting thetransformergene in a SCIC approach aimed for SIT-mediated releases upon radiation-based sterilisation. Knock-out oftransformerinduced partial to full female-to-male sex-conversion, with remaining individuals all being intersex and sterile. SCIC population modelling shows superior performance to traditional population control strategies, allowing for faster population elimination with fewer released sterile males. Our results build the foundation for further genetic pest control methods ofC. capitataand related tephritid agricultural pests.Significance statementAgricultural industry faces increasing threat from a multitude of pests including the domineering tephritid fruit flies. Genetic engineering of these pests has been recently tested to develop more efficient and affordable population control strategies. Here, we develop a new approach to improve existing population control measures by testing it in one of the most famous and dangerous tephritids, the Mediterranean fruit fly. Through optimisation, we achieved desired outcomes: female fly absence achieved via semi and full female-to-male sex conversion by CRISPR-mediated genome editing through gene mutations. For the first time in this insect, we used a split, and thus inducible, approach for such genome editing. Our work holds the potential to significantly improve tephritid population control strategies.
Dynamic p21-dependency during quiescence arrest unveiled by a rapid p21 depletion system
Authors: Zheng Dianpeng , Ai Zhipeng , Qiu Suwen , Song Yue , Ma Chenyang , Meng Weikang , He Feng , Liang Hongqing , Ma Jun 
Published: December 2024

Abstractp21 inhibits CDK2 activity to induce quiescence in response to stress or developmental stimulation. It is currently unclear whether p21 exhibits an equal functional importance across different stages and states of the quiescence arrest. Here employing a rapid p21 degradation system, we evaluate the contribution of p21 across heterogeneous quiescence arrest states during quiescence progression. Our findings reveal that cells exhibit a dynamics dependency on p21 during quiescence arrest. At low levels of p21, quiescence is exclusively dependent on p21-mediated inhibition of CDK2 activity to prevent cell cycle progression. In contrast, when p21 accumulates to higher levels, quiescence transitions into an “auto-maintenance” state where p21 becomes less essential. Mechanistically, we found an active attenuation of the KRAS/ERK signalling pathway as a driver of reduced proliferation potential in this “auto-maintenance” state. This attenuation reinforces the robustness of quiescence through a mechanism that is independent of p21. Our results thus support a dynamic, adaptive mechanism for quiescence regulation that synchronizes the anti- and pro-proliferation signals. This mechanism is applicable over various stress or developmental quiescence context, offering a basis for cells to explore distinct quiescence states to achieve different degrees of robustness in cell cycle arrest.
A simpleex vivobladder infection model permits study of host-pathogen interactions in UTI
Authors: Köhn Rixa-Mareike , Durand Méline , Ramirez Finn Laura , Costas Ariana , Söderström Bill , Lacerda Mariano Livia , Ingersoll Molly A 
Published: December 2024

AbstractUrinary tract infections (UTI) are one of the most common infections, worldwide. To understand mechanisms of UTI pathogenesis and find new treatments, researchers often use animal models, such as mice or rats. However, studying certain phenotypes in animals can be difficult. Additionally, using animals in research comes with significant administrative and ethical challenges. To address these challenges, we developed a simple, reproducible, and cost-effective model to study UTI using donated mouse bladder tissue that would otherwise be discarded. This model allows researchers of all experience levels to study interactions between the host and pathogen in a controlled environment. We tested uropathogenicE. colicolonization and invasion of isolated urothelial sheets from 30 minutes to 24 hours, finding that bacterial burden in ourex vivomodel was comparable toin vivoUTI mouse models. To optimize reproducibility, we tested multiple variables, including technical parameters, such as incubator conditions, and biological factors, such as biological sex or prior pregnancy in the donor mouse. This method offers several advantages, including assessment of early host-pathogen interactions, immune cell uptake of bacteria, the impact of age and sex of donor animals in infection, and diverse bacterial strains, mutants, or treatments. In addition, in some countries, sharing material recovered from animals sacrificed for other reasons does not require additional ethical approval by the receiving laboratory, providing a resource for labs without access to animals and reducing administrative burden. Given the breadth of the model with respect to sex, age, mouse and bacterial strain, and the ability to test any parameter that can be included in a 96-well plate, we believe this model will be useful to UTI researchers, with potential application beyond infection or even beyond the bladder to other tissues.
Decoherence of dielectric particles by thermal emission
Authors: Schäfer Jonas , Stickler Benjamin A. , Hornberger Klaus 
Published: December 2024

Levitated nanoparticles are a promising platform for sensing applications and for macroscopic quantum experiments. While the nanoparticles' motional temperatures can be reduced to near absolute zero, their uncontrolled internal degrees of freedom remain much hotter, inevitably leading to the emission of heat radiation. The decoherence and motional heating caused by this thermal emission process is still poorly understood beyond the case of the center-of-mass motion of point particles. Here, we present the master equation describing the impact of heat radiation on the motional quantum state of arbitrarily sized and shaped dielectric rigid rotors. It predicts the localization of spatio-orientational superpositions only based on the bulk material properties and the particle geometry. A counterintuitive and experimentally relevant implication of the presented theory is that orientational superpositions of optically isotropic bodies are not protected by their symmetry, even in the small-particle limit.

Published by the American Physical Society
2024
Introducing accounting small talk: on genres of accounting talk
Authors: Nordlund Isabella , Catasús Bino , Kaarbøe Katarina 
Published: December 2024

PurposeThe purposes of this paper are to explore accounting talk events and to contribute to the literature by presenting a model of accounting talk genres.Design/methodology/approachIn the qualitative tradition, interviews were conducted with accountants in both private and public sector. The pandemic provided a natural experiment, as the implemented restrictions gave rise to a situation in which accountants had to prepare and communicate numbers while working remotely. Using sociolinguistics, the paper analyzes the interactions between accountants and other organizational members when remotely preparing and communicating reports.FindingsThis study develops a conceptual model that illustrates the significant influence of accounting small talk on the production and presentation of financial information. The analysis reveals various genres of accounting talk in the everyday practice of management accountants. In so doing, the study makes three contributions. First, it provides a conceptual model of accounting talk. Second, it highlights the role of accounting small talk in creating a less risky environment for reflection, which facilitates the exchange of thoughts and ideas. Third, it offers an explanation of why even so-called bean counters can benefit from accounting small talk. It suggests that such informal communication can not only enhance efficiency by helping to ensure accurate accounts but also improve quality by aligning the numbers with more realistic forecasts.Research limitations/implicationsWe encourage future studies of accounting discourse in settings that are more similar to everyday work environments. Additional insights could also be gained by drawing upon other methods, such as conversation analysis and ethnographic studies. This paper may help controllers to be more aware of how they use talk in addition to numbers. The knowledge provided here is also important for the education of future controllers.Originality/valueThe paper provides a conceptual model of how organizational members talk about accounting, which may enable a more detailed analysis of accounting talk. The study also highlights the importance of accounting small talk, which has been largely overlooked in accounting literature.
Reconceptualising brand transgressions in the context of sacred consumption: an institutional perspective
Authors: Kaur Simran , Chong Yit Sean , Ahmed Pervaiz Khalid , Ali Md Yunus 
Published: December 2024

PurposeThis research investigates how religion uniquely influences consumer behaviour by exploring the dynamics when a brand transgression violates a religious norm. Specifically, the study focusses on the Halal consumption context, where brand transgression involves a breach of trust in Halal-certified brands. We draw upon assimilation contrast effects theory and institutional theory to examine customer responses following a religion-related transgression and identify effective recovery strategies in this unique context.Design/methodology/approachWe employed three scenario-based experiments to examine Muslim consumers’ responses following a transgression involving a Halal-certified brand. Study 1 examines the impact of a religion-related brand transgression on brand trust and behavioural intentions (relative to general brand transgression). In Study 2 and Study 3, we draw on institutional theory to highlight institutional actors’ role in influencing consumer behaviour in religion-related transgression.FindingsStudy 1 revealed that trust and behavioural intentions were significantly lower following a religion-related brand transgression compared to a general brand transgression. Further insights from Studies 2 and 3 highlighted the role of institutions in improving consumer trust and behavioural intentions after a religion-related brand transgression.Originality/valueThis research examines brand transgressions within sacred consumption, emphasising the unique triadic relationship involving consumers, brands and “The Sacred.” Unlike previous studies that predominantly address competency-based violations, this study extends beyond the conventional dyadic consumer-brand perspective to understand how brands can recover when a sacred relationship is breached. By bridging sacred consumption and institutional theory, this study offers novel insights, highlighting the importance of engaging religious gatekeepers in brand recovery efforts to restore trust and legitimacy.
Examining the consumer behaviour of ultra-processed food products: evidence from the Spanish market
Authors: Calvo-Porral Cristina , Rivaroli Sergio 
Published: December 2024

PurposeUltra-processed food products are omnipresent in our homes and in grocery stores, and everybody consumes these food products once in a while. In this context, the present study aims to analyse what factors influence the consumption behaviour of ultra-processed food products and, more precisely, what factors drive consumer satisfaction and purchase intention of these food products in one specific market – Spain-.Design/methodology/approachA model of consumer behaviour of ultra-processed food products is proposed and analysed through structural equation modelling on a sample of 608 consumers.FindingsFindings indicate that the effortlessness of ultra-processed food products, as well as their affordability, are the factors that exert the higher influence on consumer satisfaction and purchase intention of ultra-processed food products. On the other hand, the product quality and the ability to save time show a negative influence on both consumer satisfaction and intention to purchase. Contrary to the initial expectations, product convenience and the hedonistic nature of ultra-processed food products do not influence consumer behaviour.Practical implicationsFood policymakers and public health interventions may consider possible actions to reduce the consumption of ultra-processed food products, the reduction of their affordability through taxation or the compulsory inclusion of nutritional warnings in the front of the package to confront marketing actions developed by food companies.Originality/valueThis study examines the factors that drive the purchase and consumption of ultra-processed food products in one European mature market: Spain.
Understanding provider behavior in the sharing economy: an experimental study on risk, value perception, and regulatory focus effects
Authors: Dalla Valle Pedro Brandão , de Matos Celso Augusto , Herter Marcia Maurer 
Published: December 2024

Purpose
This study aims to examine providers’ intentions to engage with sharing platforms, focusing specifically on how perceptions of risk and value influence the intention to participate, considering the moderation effect of regulatory focus.

Design/methodology/approach
Two laboratory experimental studies were conducted. Study 1 examined the relationship between risk and value perception on the intention to provide. Study 2 replicated and extended the results by testing regulatory focus as a moderator.

Findings
The findings confirmed that risk perception negatively impacted the intention to provide, while value perception mediated a positive effect on the intention to provide. In addition, promotion versus prevention focus was supported as a significant moderator; providers with a prevention focus (vs promotion) presented reduced intentions to supply on sharing platforms because of their concerns about negative consequences.

Practical implications
Sharing platforms actively communicate safety measures on social networks to reduce users’ perceived risks. This study demonstrates that providers with a preventive focus are less inclined to engage in sharing platforms because they avoid risks. Therefore, platforms should not only communicate the rewards of sharing and mechanisms that reduce the perceived risk but also segment potential providers based on their regulatory focus profiles to effectively attract more providers to their platforms.

Originality/value
This study analyzes the sharing behavior in peer-to-peer platforms by focusing on the provider side, whereas most previous studies address the user (customer) side. In addition, the adoption of the experimental design allows for a better understanding of the influence of risk and value perceptions on the intention to provide, considering the moderation effect of regulatory focus.
Secularchy: suppressing the sacred in international business
Authors: Zyad Al Waqas Bin Abi , Ul-Haq Shoaib , Rauf Ateeq Abdul 
Published: December 2024

Purpose
The purpose of this paper is to explore and critically examine the integration of religious perspectives in diversity and inclusion (D&I) initiatives in the context of international business (IB).

Design/methodology/approach
This qualitative study used a case study methodology, focusing on an international consulting firm, inspired by Islamic Sufism, and their clients in South Africa and Pakistan. Data were collected through semi-structured interviews with consultants and clients from 25 organizations, participant observations during training sessions, and document analysis. Thematic analysis was used to identify and analyse patterns in the data.

Findings
The study revealed that religious ideas and individuals are marginalized in the global business environment through a phenomenon termed “secularchy”. Consultants from the Islamic Sufi-inspired firm had to detach religious elements from their management model to gain acceptance in secular corporate settings. Participants reported that religious perspectives were systematically excluded and those expressing religious viewpoints faced significant barriers. The findings emphasize the need for more inclusive D&I practices that genuinely integrate religious diversity into organizational cultures.

Originality/value
This study introduces the concept of “secularchy” to describe the systemic marginalization of religious perspectives in IB, a novel contribution to the D&I literature. The authors challenge the dominant secular paradigm in global business, advocating for more equitable and inclusive integration of religious diversity in organizational practices.
How to develop and validate experimental scenarios?
Authors: Lelo de Larrea Gabriela 
Published: December 2024

Purpose
This critical reflection aims to introduce a five-step process to develop and validate experimental scenarios.

Design/methodology/approach
The five-step process was developed by analyzing academic articles, research methodology books and encyclopedias. The researcher then synthesized the learnings and formulated foundational steps for developing and validating experimental scenarios. To illustrate this process, an example of its application in a service innovation acceptance study is presented.

Findings
A review of academic sources revealed a lack of clear guidance on developing and validating experimental scenarios. The synthesis of fragmented information in the literature resulted in a five-step process for developing and validating experimental scenarios.

Research limitations/implications
The resulting process serves as a first-of-its-kind research guide that enhances the validity and replicability of scenario-based experiments while addressing the gaps in scenario development and increasing the accessibility and impact of experimental research.

Originality/value
This study contributes to the body of knowledge by addressing a methodological shortcoming in the literature, providing a clear process for developing valid experimental scenarios. To the best of the author’s knowledge, this is the first time that a systematic, easy-to-follow process for developing and validating scenarios is advanced.
Unveiling the potential of generative artificial intelligence: a multidimensional journey into the future
Authors: Ooi Keng-Boon , Koohang Alex , Aw Eugene Cheng-Xi , Cham Tat-Huei , Cobanoglu Cihan , Dennis Charles , Dwivedi Yogesh K , Hew Jun-Jie , Linton Kelly Heather , Hughes Laurie , Lin Chieh-Yu , Mishra Anubhav , Phau Ian , Raman Ramakrishnan , Sigala Marianna , Tang Yun-Chia , Wong Lai-Wan , Tan Garry Wei-Han 
Published: December 2024

PurposeThe launch of ChatGPT has brought the large language model (LLM)-based generative artificial intelligence (GAI) into the spotlight, triggering the interests of various stakeholders to seize the possible opportunities implicated by it. Nevertheless, there are also challenges that the stakeholders should observe when they are considering the potential of GAI. Given this backdrop, this study presents the viewpoints gathered from various subject experts on six identified areas.Design/methodology/approachThrough an expert-based approach, this paper gathers the viewpoints of various subject experts on the identified areas of tourism and hospitality, marketing, retailing, service operations, manufacturing and healthcare.FindingsThe subject experts first share an overview of the use of GAI, followed by the relevant opportunities and challenges in implementing GAI in each identified area. Afterwards, based on the opportunities and challenges, the subject experts propose several research agendas for the stakeholders to consider.Originality/valueThis paper serves as a frontier in exploring the opportunities and challenges implicated by the GAI in six identified areas that this emerging technology would considerably influence. It is believed that the viewpoints offered by the subject experts would enlighten the stakeholders in the identified areas.