bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Clinical Performance and Effectiveness of the Multiple-Attending-Physicians System Compared with the Single-Attending-Physician System in Inpatient Setting: A Mixed-Method Study
Authors: Park Daeho , Hamada Toshihiro , Imaoka Shintaro , Taniguchi Shohei , Ohtsuka Yuma , Wakunami Yu , Lee Young , Kamimoto Minako , Inoue Kazuoki , Son Daisuke , Matsumoto Hiromi , Shimosaka Takuya , Sasaki Shuichi , Lee Youngee , Koda Masahiko , Taniguchi Shin-ichi 
Published: July 2021

Abstract
BackgroundConsidering work styles especially of solo attending physicians, medical facilities have been required to effectively utilize sufficient human resources in many countries. Therefore, we compared cross-sectionally clinical performance of the single- and the multiple-attending physicians groups in inpatient care. Furthermore, we also qualitatively analyzed physicians’ working burden and quantitively assessed advantages / disadvantages of those attending physicians systems.MethodIn this cross-sectional study, we extract electronic health record of patients from a hospital in Japan from April 2017 to October 2018 to compare anonymous statistical data including average lengths of hospital stay and patient outcome between the single-attending and multiple-attending-physicians system. Then, we conducted a questionnaire survey for all physicians of single and multiple-attending physician systems, asking their physical and psychiatric working burden, and their reasons and comments on their working styles.ResultThe average length of hospital stay was significantly shorter in the multiple-attending physicians system than in the single-attending physicians system, while patients’ age, gender and diagnoses were similar. From the questionnaire survey, although physical burden in multiple-attending physicians system tended to be lower than that in single-attending physician system, no significant difference was found in all categories. Advantages of multiple-attending physicians system extracted from qualitative analysis are 1) Improvement of physicians ’ quality of life (QOL), 2) Lifelong-learning effect, and 3) Improving the quality of medical care, while disadvantages were 1) Risk of miscommunication, 2) Conflicting treatment policies among physicians, and 3) unfamiliar culture with multiple-attending physicians system.ConclusionMultiple-attending-physicians system in inpatient care may reduce physical burden on physicians, and not only improve QOL of physicians but lead to lifelong learning and improving the quality of medical care.
Cancer Patients’ Preferences for Psychological Counselling: A Cross-Sectional Study Using Full-Profile Conjoint Analysis in Japan
Authors: Kanako Ichikura , Sayuri Shimizu , Noriko Oshima , Yosuke Ariizumi , Toshihide Fujie , Shin-ichi Yamauchi , Toshiaki Ishikawa , Yasuaki Nakajima , Yuko Fukase , Norio Murayama , Hanako Murase , Hirokuni Tagaya , Takashi Takeuchi , Satoshi Miyake , Eisuke Matsushima 
Published: July 2021

Abstract
Background: Psychological counselling is an effective non-pharmacological intervention for cancer patients facing psychological distress. However, there are barriers to applying counselling in clinical settings because some cancer patients feel that it is a burden and subsequently drop out. This study assessed cancer patients’ preferences for psychological counselling using a conjoint analysis approach.Methods: We conducted a single-center, cross-sectional study using a self-reported questionnaire. The data were collected from outpatients and inpatients at the departments of Respiratory Medicine, Gastrointestinal Surgery, Female Pelvic Surgery, and Head and Neck Surgery from a university hospital between March 2018 and March 2020. The questionnaire, developed from an interview with a clinical psychologist, asked for patients’ preferences for counselling with 48 scenarios according to a combination of type, length, price, and frequency. We conducted a conjoint analysis, calculating the relative importance and part-worth value of each factor.Results: According to the conjoint analysis modeling, cancer patients consider the type as the most important factor when deciding whether to undergo counselling (relative importance: 37.5%), followed by frequency (23.4%), price (19.6%), and length (19.5%). Cancer patients value life reviews highly among the four counselling types. However, women and younger patients valued counselling for emotional control the highest, with advanced cancer patients valuing counselling for problem solving the most.Conclusions: The results reveal that cancer patients consider the type and content of counselling to be the most important factors in the selection process, although preferences depend on individual characteristics. This is the first study to clarify cancer patients’ preferences for psychological counselling using conjoint analysis and proposes a new economical method in the psycho-oncology field.
New Primary Vs True Recurrence In Relapsed Retroperitoneal Liposarcoma: An Analysis of Clinicopatholgical Characteristic Differences And Relapse-Free Survival
Authors: Deng Huan , Cao Bo , Cui Hao , Liu Guibin , Li Hanghang , Song Liqiang , Zhao Ruiyang , Chen Runkai , Wei Bo 
Published: July 2021

Abstract
Background This study aimed to classify relapsed retroperitoneal liposarcoma (RLS) as new primary (NP) or true recurrence (TR) and to assess the implications for therapeutic management of these classifications. Methods Patients with recurrent RLS were classified as NP if the relapse was different from the former tumor’s pathology subtype and anatomical location. Kaplan-Meier curves were adapted to estimate relapse-free survival (RFS), and logistic regression analysis was used to explore the factors related to NP.Results Total 177 patients with relapsed RLS were included in this study. The median tumor sizes were 16 cm (IQR, 13-22 cm, NP) and 18 cm (IQR, 12-25 cm, TR) (P=0.003). Multifocal tumors (89.2% vs 73.8%, P=0.011) and multiple pathology subtypes (52.7% vs 31.1%, P=0.004) were more common in the NP group and tended to invade wider anatomical areas (85.1% vs 71.8%, P=0.037). The median RFS was 17 months (IQR, 7-35 months) in the NP group and 12 months (IQR, 5-23 months) in the TR group, and NP patients showed a longer RFS than TR patients (P=0.004). When the log-rank test was conducted, low-grade pathology, tumor growth rate ≤ 1.25 cm/month and tumor size ≤ 16.5 cm had a significant influence on the NP phenomenon (P=0.015, 0.019, and 0.028, respectively). Logistic regression analysis illustrated that current surgeries, pathology subtype varieties and pathology grade were independent risk factors for NP (P=0.017, 0.019, and 0.025, respectively).Conclusion NP patients have longer RFS than TR patients, and their tumors tend to have multiple pathology subtypes and tumors and are more likely to invade wider anatomical areas. This classification contributes to a better understanding of RLS and provides new evidence for different therapeutic management of relapsed tumors.
From Networked Robotics to Cloud and Big Data Supercharged Robotics: A Survey and Analysis
Authors: Chowdhury Muhammed Tawfiq , Yan Feng 
Published: July 2021

Abstract
In recent years, with the prosperity of big data and cloud computing, robotics is evolving from conventional networked robotics to internet-scale connected, big data driven, and cloud resources supercharged multi-robot systems. In this survey paper, we present a survey of an advancing, pioneering, and multi-disciplinary ﬁeld of research at the intersection of wireless sensor networks (WSN), robotics and big data. We discuss the concepts of networked robots. Networked robots refer to multiple robots working together in coordination with diﬀerent types of embedded computers, sensors, and human users. Networked robotics allows multiple robots and supporting entities to execute tasks that are well beyond the capabilities of a single robot. The recent initiation of cloud technologies is opening new prospects for the provisioning of advanced robotic services based on the cooperation of some connected robots, smart environments and devices powered by the huge computational and storage capability of the cloud servers. We have recently witnessed the emergence of cloud computing on one hand and robotics platforms on the other hand. These two areas have been merging and resulting in the cloud robotics model to oﬀer more distant services. Since networked robots require high computational and processing power, big data is becoming a dominant factor in networked and cloud robotics. This survey paper elaborates the primary concepts of networked and cloud robotics, their applications, challenges as well as the importance of big data in robotics, particularly, networked and cloud robotics and the noteworthy works in these areas.
Genetic Mechanisms Determining Grain Number Distribution Along the Spike and Their Effect on Yield Components in Wheat
Authors: Mizuno Nobuyuki , Ishikawa Goro , Kojima Hisayo , Tougou Makoto , Kiribuchi-Otobe Chikako , Fujita Masaya , Nakamura Kazuhiro 
Published: July 2021

Abstract
The number of wheat grains is one of the major determinant of yield. Many quantitative trait loci (QTLs) and some causal genes such as GNI-A1 and WAPO-A1 that are associated with grain number per spike (GNS) have been identified, but the underlying mechanisms remain largely unknown. We analyzed QTLs for grain number and other related traits using 188 doubled haploid lines derived from the Japanese high-yield variety, Kitahonami, as a parent to elucidate the genetic mechanism determining grain number. The major QTLs for grain number at the apical, central and basal parts of the spike were identified in different chromosomal regions. We considered GNI-A1 and WAPO-A1 as candidate genes controlling grain number at the central and basal parts of the spike, respectively. Kitahonami had the favorable 105Y allele of GNI-A1 and WAPO-A1b allele, and unfavorable alleles of QTLs for grain number at the apical part of spikes. Pyramiding the favorable alleles of these QTLs significantly increased GNS without significantly reducing thousand-grain weight (TGW). In contrast, the accumulation of favorable alleles of QTLs for TGW significantly decreased GNS, whereas days to heading positively correlated with GNS. Late heading increased the spikelet number per spike, resulting in a higher GNS. Pyramiding of the QTLs for TGW and days to heading also altered the GNS. In conclusion, GNS is a complex trait controlled by many QTLs, and it is essential for breeding to design.
The continuity of prime numbers can lead to even continuity(The ultimate)
Authors: Ling Xie 
Published: July 2021

Abstract
n continuous prime numbers can combine a group of continuous even numbers. If an adjacent prime number is followed, the even number will continue.For example, if we take prime number 3, we can get even number 6. If we follow an adjacent prime number 5, we can get even numbers by using 3 and 5: 6, 8 and 10.If a group of continuous prime numbers 3,5,7,11,... P, we can get a group of continuous even numbers 6,8,10,12,..., 2n. Then if an adjacent prime number q is followed, the original group of even numbers 6,8,10,12,..., 2n will be finitely extended to 2 (n + 1) or more adjacent even numbers. My purpose is to prove that the continuity of prime numbers will lead to even continuity as long as 2 (n + 1) can be extended.If the continuity of even numbers is discontinuous, it violates the Bertrand Chebyshev theorem of prime numbers.Because there are infinitely many prime numbers: 3, 5, 7, 11,...We can get infinitely many continuous even numbers: 6,8,10,12,...
Transmission of Multidrug/Rifampicin-Resistant Mycobacterium Tuberculosis in Chongqing, China: A Retrospective Observational Study Using Whole-Genome Sequencing
Authors: Zhao Bing , Liu Chunfa , Fan Jiale , Ma Aijing , He Wencong , He Guangxue , Hu Yan , zhao yanlin 
Published: July 2021

Abstract
Background: Multidrug/rifampicin-resistant tuberculosis (MDR/RR-TB) is a global barrel for ‘Stop TB plan’. China has the second highest MDR/RR-TB burden in whole world wide. Understanding the transmission dynamic is facilitated for disease control. Methods: Whole genome sequencing (WGS) data from patients of Chongqing tuberculosis control institute were used for phylogenetic classifications, resistance predictions, and cluster analysis as indicator for recent transmission (RT). Factors associated with MDR/RR-TB were defined by a logistic regression model. Results: A total of 223 cases of MDR/RR-TB were recorded between Jan 1, 2018 and Dec 31, 2020, and 200 cases obtained relevant treatment information. The patients who are older than 55 year old were more likely to suffering from death. 178 MDR/RR strains were obtained WGS data, 152 were classified as lineage 2 strains. 80 (44.9%, 80 of 178) strains were in 20 genomic clusters that differed by 12 or fewer single nucleotide polymorphisms (SNPs), indicating RT. Patients who were infected with lineage 2 strains is a significant factor driving the epidemic towards MDR/RR-TB. Resistance mutations of first-line tuberculosis drugs analysis found that 79 (98.8%) of all 80 strains defined as RT have same mutations among each clusters totally. 55% (44 of 80) of the MDR/RR-TB strains accumulated additional drug resistance mutations along the transmission chain, especially fluoroquinolones (FQs) (63.6%, 28 of 44). Conclusions: The age is the most significant factor that causes death of MDR/RR-TB patients. RT of MDR/RR strains is not only drove the MDR/RR-TB epidemic, but also accumulated more serious resistance along the transmission chains.
The Effects of Verapamil, Hydralazine and Doxazosin on Renin, Aldosterone and The Ratio Thereof
Authors: Veldhuizen Gregory P , Alnazer Rawan M , de Leeuw Peter W. , Kroon Abraham A 
Published: July 2021

Abstract
PURPOSE

Hydralazine, doxazosin and verapamil are currently recommended by the Endocrine Society as acceptable bridging treatment in those in whom full cessation of antihypertensive medication is infeasible during screening for primary aldosteronism (PA). This is under the assumption that they cause minimal to no effect on the aldosterone-to-renin ratio, the most widely used screening test for PA. However, limited evidence is available regarding the effects of these particular drugs on said ratio.
METHODS

In the present study, we retrospectively assessed the changes in aldosterone, renin and aldosterone-to-renin values in essential hypertensive participants before and after treatment with either hydralazine (n = 26), or doxazosin (n = 20) or verapamil (n = 15). All samples were taken under highly standardised conditions.
RESULTS

Hydralazine resulted in a borderline significant rise in active plasma renin concentration (19 vs 25 mIU/L, p = 0.067) and a significant fall in the aldosterone-to-renin ratio (38 vs 24, p = 0.017). Doxazosin caused declines in both plasma aldosterone concentration (470 vs 330 pmol/L, p = 0.028) and the aldosterone-to-renin ratio (30 vs 20, p = 0.020). With respect to verapamil, we found no statistically significant effect on any of these outcome variables.
CONCLUSION

We conclude that the assumption that these drugs can be used with little consequence to the aldosterone-to-renin cannot be substantiated. While it is possible that they are indeed the best option when full antihypertensive drug cessation is infeasible, the potential effects of these drugs must still be taken into account when interpreting the aldosterone-to-renin ratio.
Synthetic Phytosiderophore, Proline-2′-Deoxymugineic Acid, is Efficiently Utilized by Dicots
Authors: Ueno Daisei , Ito Yuta , Ohnishi Miho , Miyake Chikahiro , Sohtome Takayuki , Suzuki Motofumi 
Published: July 2021

Abstract
Purpose: Phytosiderophores (PS) from grasses solubilize sparingly soluble iron (Fe), and the resultant PS-Fe is an Fe source, even for dicots. Recently, the synthetic PS proline-2′-deoxymugineic acid (PDMA) has been developed as a moderately biodegradable Fe fertilizer for grasses. We aimed to investigate whether PDMA-Fe is also a good Fe source for dicots.Methods: The availability of PDMA-Fe to cucumber was evaluated in calcareous soil and hydroponic cultures under pH 7.0–9.0 by determining chlorophyll concentration, PSII activity, and Fe uptake. EDDHA-Fe, EDTA-Fe, and citrate-Fe were used as controls. The reducibility of Fe chelates by roots was measured to determine the mechanism underlying differences in availability. Expressions of Fe deficiency-inducible genes (CsFRO1 and CsIRT1) were analyzed to estimate the Fe status in plants. Results: Application of PDMA-Fe and EDDHA-Fe to calcareous soil reduced Fe-deficient chlorosis to a similar extent; however, shoot Fe concentration was higher in the PDMA-Fe treatment. In the hydroponic culture, PDMA-Fe had higher availability than the other chelates at every pH, which was confirmed by higher PSII activity and lower expression of Fe deficiency-inducible genes. The reducibility assay revealed that the reduction level of PDMA-Fe was greater than that of EDTA-Fe and citrate-Fe under alkaline pH.Conclusion: PDMA-Fe is utilized by cucumber roots more efficiently than traditional synthetic chelates in both calcareous soil and hydroponic cultures. The higher availability of PDMA-Fe may be attributed to its higher reducibility. Our findings suggest that PDMA-Fe could be a good Fe fertilizer for dicots.
Overexpression of MdIPT8 Encodes an Isopentenyl Transferase Enzyme Enhances Resistance to Colletotrichum Gloeosporioides in apple (Malus Domestica)
Authors: Shi Jiajun , Zhang Feng , Jiang Qiu , Yuan Yuhong , Nie Xiaolin , Zhou Ying , Wang Zhigang , Ma Yue , Wang Feng 
Published: July 2021

Abstract
Apple (Malus domestica) is a delicious fruit and have high economic value. However, numerous destructive fungi affect apple tree and limit the development of apple production. Many researches showed that salicylic acid and jasmonic acid improved plant resistance to fungal disease, but the potential mechanisms between cytokinin and fungal disease were hardly reported. The IPT gene family encodes the proteins of synthetizing cytokinin and plays an indispensable role in plant biological stress. In our previous study, we found the disease resistance in autotetraploid apple was much better than ‘Hanfu’ and we analyze the gene expression in ‘Hanfu’ and autotetraploid apple. We found the MdIPT8 gene was significantly different expressed. Therefore, we focused on MdIPT genes. We uncovered ten IPT genes in the ‘Hanfu’ whole genome, that are unevenly distributed across five chromosomes. Phylogenetic analysis indicated this family falling into two groups. Moreover, the transcriptional analysis of ten IPT genes indicated MdIPT8 can be induced under Colletotrichum gloeosporioides stress stimulating in apple leaves. The MdIPT8 protein coalesced to green fluorescent protein pinpointed to the chloroplast. Finally, we confirmed that the overexpression of MdIPT8 increased resistance to C. gloeosporioides. Additionally, the endogenous cytokinin content of ‘Hanfu’ leaves increased under the stress of C. gloeosporioides and exogenous cytokinin improved the disease resistance of leaves. Our findings supply an overview of the identification of apple IPT gene family and increases the understanding of cytokinin in apple anthracnose resistance study.
Neutrophil Extracellular Traps Participate in the Development of Gastric Cancer Associated Thrombosis
Authors: Li Jiacheng , Zou Xiaoming , Yang Shifeng , Jin Jiaqi , Zhu Lei , Li Changjian , Yang Hao , Zhang Ange , Chen Chongyan 
Published: July 2021

Abstract
Background: Development of venous thromboembolism (VTE) is associated with high mortalities among gastric cancer (GC) patients. Neutrophil extracellular traps (NETs) have been reported to correlated with prothrombotic state in some diseases. We hypothesize that NETs participate in the development of GC-associated thrombosis.Methods: The level of NETs in blood and tissue samples of patients were analyzed by ELISA, flow cytometry and immunofluorescence (IF). NETs generation and hypercoagulation of platelets and endothelial cells (ECs) in vitro were observed by IF. NETs procoagulant activity (PCA) was performed by fibrin formation and thrombin-antithrombin complex (TAT) assays. Thrombosis in vivo was measured in murine model induced by flow stenosis in the inferior vena cave (IVC).Results: NETs were likely to form in blood and tissue samples of GC patients compared with healthy individuals. In vitro studies that GC cells and their conditioned medium (CM), but not gastric mucosal epithelial cell can stimulate NETs releasing from neutrophils. In addition, NETs induced hypercoagulable state of platelets by up-regulating the expression of phosphatidylserine (PS) and P-selectin on the cells. Furhter, NETs stimulated adhesion of normal platelets on glass surfaces. Similarly, NETs triggered the conversion of ECs to hypercoagulable phenotypes by down-regulating the expression of their intercellular tight junctions but up-regulating that of tissue factor (TF). Treatment of normal platelets or ECs with NETs augmented the level of plasma fibrin formation and TAT complex. Meanwhile, in the models of IVC stenosis, tumor-bearing mice showed stronger ability to form thrombi and NETs were abundantly accumulated in the thrombi compared with control mice. Notably, combination of DNase-1, activated protein C (APC) and Sivelestat markedly abolished the PCA of NETs.Conclusions: Our findings demonstrate that GC-induced NETs strongly increase the risks of VTE development both in vitro and in vivo. NETs are potential therapeutic targets in the prevention and treatment of VTE in GC patients.
The Functional Outcome of Patients Following Spinal Injury in Asia Metropolitans: Does the Prehospital Spine Immobilization Matter?
Authors: Chen Hsuan An , Hsu Shuo Ting , Shin Sang Do , Jamaluddin Sabariah Faizah , Son Do Ngoc , Hong Ki Jeong , Tanaka Hideharu , Sun Jen Tang , Chiang Wen-Chu 
Published: July 2021

Abstract
Prehospital spinal immobilization is a widely used procedure in the emergency medical service (EMS) system worldwide, while the incidence of patients with spinal injury (SI) is relatively low, and unnecessary prehospital spinal immobilization is associated with patient complications. This study aimed to determine the association between prehospital spine immobilization and favorable functional outcomes at hospital discharge among trauma patients with SI. We conducted a retrospective cohort study using the Pan-Asia Trauma Outcomes Study (PATOS) registry data from January 1, 2016, to November 30, 2018. A total of 759 patients with SI were enrolled from 43,752 trauma patients in the PATOS registry during the study period. The subjects had a median age of 58 years ( Q1−Q3,41−72), and 438 (57.7%) patients had prehospital spine immobilization. Overall, prehospital spinal immobilization was not associated with favorable functional outcomes at discharge in multivariable logistic regression (aOR, 1.06; 95%CI 0.62−1.81, p = 0.826). However, in the subgroup of cervical SI, prehospital spinal immobilization was associated with favorable functional outcomes at discharge (aOR, 3.14; 95%CI 1.04−9.50; p = 0.043). Therefore, we suggest that paramedics should be more careful when determining cervical SI and using prehospital immobilization.