bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling Gene Expression and Protein Delivery as an End-to-End Digital Communication System
Authors: Cevallos Yesenia , Nakano Tadashi , Tello-Oquendo Luis , Inca Deysi , Santillán Ivone , Shirazi Amin Zadeh , Rushdi Ahmad , Samaniego Nicolay 
Published: November 2021

Introduction:
Digital communication theories have been well-established and extensively used to model and analyze information transfer and exchange processes. Due to their robustness and thoroughness, they have been recently extended to the modeling and analyzing data flow, storage, and networking in biological systems.

Methods:
This article analyses gene expression from a digital communication system perspective. Specifically, network theories, such as addressing, error control, flow control, traffic control, and Shannon's theorem are used to design an end-to-end digital communication system representing gene expression. We provide a layered network model representing the transcription and translation of deoxyribonucleic acid (DNA) and the end-to-end transmission of proteins to a target organ. The layered network model takes advantage of digital communication systems' key features, such as efficiency and performance, to transmit biological information in gene expression systems.

Results:
Thus, we define the transmission of information through a bio-internetwork (LAN-WAN-LAN) composed of a transmitter network (nucleus of the cell, ribosomes and endoplasmic reticulum), a router (Golgi Apparatus), and a receiver network (target organ).

Conclusion:
Our proposal can be applied in critical scenarios such as the development of communication systems for medical purposes. For instance, in cancer treatment, the model and analysis presented in this article may help understand side effects due to the transmission of drug molecules to a target organ to achieve optimal treatments.
A Blockchain-Based Dynamic Consent Architecture to Support Clinical Genomic Data Sharing (ConsentChain): Proof-of-Concept Study
Authors: Albalwy Faisal , Brass Andrew , Davies Angela 
Published: November 2021

BackgroundIn clinical genomics, sharing of rare genetic disease information between genetic databases and laboratories is essential to determine the pathogenic significance of variants to enable the diagnosis of rare genetic diseases. Significant concerns regarding data governance and security have reduced this sharing in practice. Blockchain could provide a secure method for sharing genomic data between involved parties and thus help overcome some of these issues.ObjectiveThis study aims to contribute to the growing knowledge of the potential role of blockchain technology in supporting the sharing of clinical genomic data by describing blockchain-based dynamic consent architecture to support clinical genomic data sharing and provide a proof-of-concept implementation, called ConsentChain, for the architecture to explore its performance.MethodsThe ConsentChain requirements were captured from a patient forum to identify security and consent concerns. The ConsentChain was developed on the Ethereum platform, in which smart contracts were used to model the actions of patients, who may provide or withdraw consent to share their data; the data creator, who collects and stores patient data; and the data requester, who needs to query and access the patient data. A detailed analysis was undertaken of the ConsentChain performance as a function of the number of transactions processed by the system.ResultsWe describe ConsentChain, a blockchain-based system that provides a web portal interface to support clinical genomic sharing. ConsentChain allows patients to grant or withdraw data requester access and allows data requesters to query and submit access to data stored in a secure off-chain database. We also developed an ontology model to represent patient consent elements into machine-readable codes to automate the consent and data access processes.ConclusionsBlockchains and smart contracts can provide an efficient and scalable mechanism to support dynamic consent functionality and address some of the barriers that inhibit genomic data sharing. However, they are not a complete answer, and a number of issues still need to be addressed before such systems can be deployed in practice, particularly in relation to verifying user credentials.
Effectiveness of a Walking Football Program for Middle-Aged and Older Men With Type 2 Diabetes: Protocol for a Randomized Controlled Trial
Authors: Barbosa Ana , Brito João , Figueiredo Pedro , Seabra André , Mendes Romeu 
Published: November 2021

Background
Studies on walking football have found positive effects on health; however, there are still several research gaps when applying walking football programs for patients with type 2 diabetes.

Objective
This study aims to test the effectiveness of a walking football exercise program on glycemic control and cardiovascular risk factors in middle-aged and older men with type 2 diabetes.

Methods
The study will be run as a randomized controlled trial with a 6-month duration in Portugal. Eligible participants will be randomized using a 1:1 ratio for intervention or control groups and compared using an intention-to-treat analysis. The intervention will consist of a walking football exercise program. The control group will continue with usual care in primary health care units. The primary outcome will be the mean difference in glycated hemoglobin between intervention and control groups after 6 months. Secondary outcomes include the mean differences in fasting blood glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure, body mass index, waist circumference, fat-free mass, and fat mass. Additionally, secondary outcomes include the incidence of exercise-related injuries and adverse events and the walking football exercise program’s cost-utility.

Results
The study protocol is being prepared to be submitted to the Health Ethics Committee of the Northern Regional Health Administration, Portugal. After approval, participant recruitment will start in primary health care units in Porto's metropolitan area by family medicine doctors.

Conclusions
Walking football might have the potential to be effective in improving glycemic control and cardiovascular risk factors, with a low rate of exercise-related injuries and adverse events and a good cost-utility ratio. Therefore, walking football may be a sustainable intervention strategy for type 2 diabetes management.

International Registered Report Identifier (IRRID)
PRR1-10.2196/28554
Etnografía Antigua General del Estado de Oaxaca
Authors: Maldonado Alvarado Benjamín 
Published: November 2021

La etnografía ofrece una mirada esencial sobre la vida de las sociedades y grupos humanos por su cercanía con ellos. En el caso de México y, en específico, de Oaxaca se ha centrado en los pueblos indígenas, pero eso no ha contribuido necesariamente a conocerlos a plenitud ni al reconocimiento de sus derechos, ni a su visibilización.
Los pueblos indígenas de México son una realidad visible y contundente, a raíz del surgimiento del Ejército Zapatista de Liberación Nacional (EZNL), en el estado de Chiapas, en enero de 1994, pero esa presencia era una realidad desconocida. Pese a décadas de estudios y políticas públicas dirigidos a los pueblos indígenas, ni la academia ni las instituciones de gobierno tenían claro quiénes conformaban esas comunidades. Numerosas investigaciones mostraban el conocimiento profundo de diversos aspectos de la cultura indígena y de la vida comunitaria, pero se trataba de estudios locales, a veces microrregionales, temáticos o relativos a alguna población, que no mostraban un panorama general de los pueblos indígenas de Oaxaca.
AFORISMO SOBRE O ECODESIGN
Authors: Guattari Félix , Lima Vladimir Moreira 
Published: November 2021

Tradução:
AFORISMO SOBRE O ECODESIGN
JÁ JOGAMOS TODAS AS CARTAS DO VIRTUAL? - Entrevista om Félix Guattari realizada no dia 29/01/91 por J.C Conesa e V. Lemarchands.
Este aforismo e a entrevista que o acompanha foram publicados em Caravelles 2. 2ème quadriennale internationale de design, Lyon: Caravelles, 22 de junho de 1991.
Application of Eigenvalues and Eigenvectors in Correlating Density and Fire Properties of Some Selected Woods in South-East Nigeria
Authors: Okafor Vincent Nwalieji , Enweonye Igwebuike , Umennadi Patrick Ugochukwu 
Published: November 2021

Data sourced from literature for wood density (WD) and fire properties for fifteen Nigerian woods were analysed. The fire properties are ignition time (IT), flame propagation rate (FPR), flame duration (FD), afterglow time (AGT), ash formation (AF) and limiting oxygen index (LOI). The aim was to correlate density and fire properties of wood using eigenvalues and eigenvectors. The analysis tool adopted was the statisticalanalysis system (SAS) where principal component and regression analyses were performed. Based on the presented data and analyses, WD was found to relate well with FPR, AGT and LOI with an adjusted R-Square = 83% while the other three parameters: IT, FD and AF constitute random noise.
2.11.0.0
2.11.0.0
Analisis Rekrutmen Calon Walikota Pada Pilkada Kota Banjar Tahun 2013
Authors: Tina Cahya Mulyatin  , Riza Purnama  
Published: November 2021

Salah satu fungsi klasik dari partai politik adalah menyangkut peran partai dalam mencalonkan jabatan di semua tingkat pemerintahan. proses perekrutan di tubuh partai merupakan kebun rahasia yang hanya diketahui oleh partai itu sendiri. Tujuan dalam Penelitian ini yaitu untuk menganalis proses terbentuknya politik dinasti di kota Banjar serta menganalisis kualifikasi kandidat pada partai Golkar di Pilkada Kota Banjar Jawa Barat tahun 2013. Penelitian ini menggunakan teori kualitas kandidat dari Jacobson dan Kernell dalam menjelaskan kualitas kandidat yang maju dari Partai Golkar dalam Pilkada di Kota Banjar tahun 2013. Sedangkan konsep pendukung dalam penelitian ini adalah model analisis dari Morgenstern dan Siavelis untuk menjelaskan rekrutmen politik. Serta konsep politik dinasti menurut Kurtz. Penelitian ini menggunakan model studi kasus dengan pendekatan deskriptif analisis. Adapun temuan dalam penelitian ini adalah terjadinya dinasti Politik di Kota Banjar dipengaruhi oleh empat faktor yaitu : pertama, kuatnya pengaruh petahana dalam mempertahankan kekuasaan dan membentuk keluarga politik. Kedua, Buruknya rekrutmen politik, ketiga dorongan kuat dari elemen masyarakat Banjar. Keempat, kekuatan financial yang besar. Kesimpulan dalam penelitian ini menjelaskan bahwa Secara keseluruhan dapat dikatakan bahwa kualitas/kualifikasi kandidat, Ade Uu Sukaesih ternyata memiliki nilai positif baik pada dimensi pendidikan, pelatihan dan pengalaman politik. Akan tetapi faktor kualitas kandidat bukanlah sebagai factor utama dalam perekrutan oleh Golkar tetapi dipengaruhi oleh faktor lain, yaitu faktor kuatnya pengaruh incumbent.
The International Academy of Cytology standardized reporting of breast fine-needle aspiration biopsy cytology: A 2 year’s retrospective study with application of categories and their assessment for risk of malignancy
Authors: Nigam Jitendra Singh , Kumar Tarun , Bharti Shreekant , Surabhi  , Sinha Ruchi , Bhadani Punam Prasad 
Published: November 2021

Objectives:
Breast cancer is the most common cancer in women worldwide. The fine-needle aspiration biopsy (FNAB) may be used as the first-line pathological investigation for evaluation and early diagnosis of the breast lesion. The FNAB helps to differentiate malignant from benign lesions. In the present study, we categorized the breast FNAB cases according to the International Academy of Cytology Yokohama System (IACYS) for reporting breast FNAB cytology and to assess the risk of malignancy (ROM) for each category.

Material and Methods:
A retrospective data of breast lesions were retrieved from the archives of pathology department between January 2018 and December 2019. The study got approval from the Institutional Ethics Committee. Only 123 cases with cytology and histopathological correlation were included in this study. The cytological category was given according to IACYS for reporting breast FNAB cytology.

Results:
The FNAB results were include as insufficient material 3.25% (4/123), benign 46.34% (57/123), atypical 12.2% (15/123), suspicious for malignancy (SM) 4.88% (6/123), and malignant 33.33% (41/123). The ROM was 50%, 7.27%, 40.0%, 83.33%, and 97.5% for NS, benign, atypical, SM, and malignant, respectively.

Conclusion:
FNAB is an important tool in the diagnosis and management of breast lesions, especially in financial constrained developing countries like India with limited resources, where practice of core needle biopsy is limited. The 5-tier IACYS for reporting breast FNAB improves the reproducibility of cytology reports across the world and helps in triaging the breast lesion patients.
Бронзовый котел с греческой надписью из курганного могильника у хут . Базки Волгоградской области
Authors: А.С. Балахванцев , О.А. Шинкарь 
Published: November 2021

В результате археологических раскопок на правом берегу р. Дон в Волгоградской области в кургане № 1 у хут. Базки в насыпи найден бронзовый кованый котел раннесарматского времени с греческой надписью на плечиках сосуда. Надпись читается как [H]ΔΔΔΖ | ΔΙΡΙNAKOY и переводится: (Вес) 181 (драхм) (собственность) Диринака. По типологическим особенностям и палеографическим данным котел можно датировать в пределах II, возможно, начала I в. до н. э.
Archaeological excavations on the right bank of the Don River in the Volgograd Region revealed a hammered bronze cauldron of the Early Sarmatian period in the mound of kurgan 1 near the Bazki farmstead. The caldron bears a Greek inscription placed on the vessel shoulders. The inscription reads as [H]ΔΔΔΖ | ΔΙΡΙNAKOY and is interpreted as (Weight) 181 (drachms) (owned by) Dirinak. Regarding typological characteristics and paleographic data, the dating puts the cauldron within II – possibly, early I century BC.
ПОГРЕБЕНИЕ МАСТЕРА-ЛИТЕЙЩИКА ЛОЛИНСКОЙ КУЛЬТУРЫ НА СТАВРОПОЛЬЕ
Authors: А.А. Калмыков , Н.Я. Березина , Ю. Грески , М.В. Добровольская , А.П. Бужилова 
Published: November 2021

Данная работа посвящена публикации и комплексному анализу погребения мастера-литейщика лолинской культуры эпохи средней бронзы, открытого в 2012 г. в степной зоне Центрального Предкавказья, недалеко от места слияния Большого Зеленчука и Кубани (рис. 1). По результатам радиоуглеродного датирования погребение отнесено к рубежу III и II тыс. до н. э. В нем обнаружен набор орудий для металлообработки: керамические тигель-льячка и сопло, а также каменный абразив (рис. 2: 2–4; 3: 2). До помещения в могилу инструменты использовались в практических целях по своему предназначению. С применением антропологических стандартов и биоархеологических подходов были изучены костные останки индивида. Это позволило реконструировать особенности его физического развития, состояния здоровья, образа жизни и, с привлечением аналогий, подтвердить связь его прижизненной деятельности с металлообработкой.
This paper presents the publication and comprehensive analysis of a smelter’s grave attributed to the Lola culture of the Middle Bronze Age discovered in the steppe zone of the Central Fore-Caucasus in 2012 not far from the confluence of the Bolshoy Zelenchuk and the Kuban’ Rivers (fig. 1). The radiocarbon dates put this burial around the transition period from the 1st to the 2nd millennia BC. It revealed a set of tools for metal working such as a ceramic crucible/clay ladle as well as a stone abrasive (fig. 2, 2–4; 3, 2). Before the tools were placed into the grave, they had been used for intended purposes. Bone remains of the deceased person were studied with the use of anthropological standards and bioarchaeological approaches. It helped reconstruct specific features of the physical development of the deceased person, his health conditions, his lifestyle and, drawing on analogies, confirm that his life activity was related to metal working.
МОГИЛЬНИК СЕРЖЕНЬ-ЮРТ: НОВЫЕ НАХОДКИ
Authors: Р.Х. Мамаев , В.И. Козенкова 
Published: November 2021

В статье публикуются новые археологические находки из известного могильника Сержень-юрт эпохи бронзы – раннего железного века, относящиеся к восточному варианту кобанской культуры (Е. И. Крупнов, В. И. Козенкова). Материалы добыты в 2014 г. местными специалистами из Отдела охраны памятников Чеченской Республики в результате экстремальных раскопок (эрозионные весенние паводки, сельскохозяйственные работы и т. п.) на территории могильного поля. Материалы X–VIII вв. до н. э. (рис. 1–4) количественно и качественно представляют исключительный интерес (особенно эксклюзивные предметы: бронзовый ажурный браслет (рис. 1: 8) и бронзовый орнаментированный боевой топор (рис. 4: III)) для уточнения общей характеристики памятника. Установлена их типологическая классификация и хронология. В статье подчеркивается необходимость усиления охраны могильника из-за очевидной угрозы разрушения в результате воздействия эрозийного природного и социального факторов.
The paper publishes new archaeological finds from the well-known Serzhen’-yurt Cemetery of the Bronze–Early Iron Age attributed to the eastern variant of the Koban culture (E. I. Krupnov, V. I. Kozenkova). These finds were retrieved in 2014 by local specialists from the Department for Protection of Historical Sites in the Chechen Republic in the course of urgent excavations caused by extreme conditions (erosion caused by spring flooding, agricultural activities, etc.) within the area of the burial ground. In terms of their quantity and quality, these materials dated to the 10th–8th centuries BC (fig. 1–4), especially, such exclusive items as a bronze open-work bracelet (fig. 1: 8) and a bronze ornamented battle axe (fig. 4: III), are of exceptional value for clarification of the overall characteristics of the site. Their typological classification and chronology were defined. The paper highlights a need to reinforce protection of the cemetery because of imminent threat of damage due to natural erosion and the social factor.
Shapes of Clay Vessels As a Subject of Study. Historical-and-Cultural Approach.
Authors: Ю.Б. Цетлин 
Published: November 2021

Сборник состоит из двух частей. Первая часть содержит статьи выдающегося советского и российского археолога-керамиста А.А. Бобринского, посвященные методам изучения форм глиняных сосудов и изданные в 1986–1999 гг., а также неопубликованную статью 1984 г. Вторая часть включает современные методические разработки анализа форм с позиций историко-культурного подхода и практические их приложения к материалам эпохи бронзы, раннего железа и раннего средневековья. Публикуемые материалы представляют интерес для всех археологов, изучающих формы глиняной посуды, а также для студентов исторических факультетов университетов.
The collection consists of two parts. The first part contains articles written by famous Soviet and Russian archeoligist and expert in pottery A.A. Bobrinsky. These articles are devoted to techniques and procedures of vessel shapes study and include papers published in 1986–1999 and the unpublished manuscript written in 1984. The second part includes the current developments of procedures of vessels shapes analysis made from the perspective of cultural-historical approach and practical application of these procedures to archeological pottery of Bronze Age, Early Iron Age and Early Middle Age. The materials published in the collection are of interest for all archeologists who study vessel shapes as well as for students of university departments of history.
Mechanisms of New Vessels’ Shapes Incorporation and Adaptation (From the book published in 1999)
Authors: А.А. Бобринский 
Published: November 2021

This short text is devoted to presentation of preliminary results of the fundamental experiment carried out by A.A. Bobrinsky in the 1970s and the 1980s on the basis of traditional pottery trade. Altogether about 40 master potters of different ages and of different skill levels took part in this experiment in different years. The experiment consisted in artificial modeling of the situation that occurred permanently in the history of pottery. We mean cases when a potter produces vessel forms that are new for him and due to specific historical reasons became “fashionable” (or sought after) in a particular society. In the experiment course it was found out that a potter who performs such task experience a disruption of traditional system of physical efforts application a potter had developed in the course of long production of traditional (customary) vessel forms range. The disruption’s result is emergence of so called “hybrid” vessel forms that were widely spread in various historical epochs, from the Neolithic Age to the late Middle Age. These “hybrid” forms co-existed with traditional vessel forms. The discovered regularities widen considerably contemporary opportunities to study these phenomena on archeological pottery.
EFFECTIVE TECHNOLOGIES FOR PROCESSING SEEDS OF OIL CROPS
Authors: Орлов Б.Ю. , Степанова Е.Г. 
Published: November 2021

На основе анализа применяемых для переработки масличного сырья машин и механизмов предложено описание технологической схемы переработки масличных семян с применением вновь разработанного оборудования участка подготовительных операций маслозавода. Рассмотрены основные виды масличного сырья, состав и сохранность семенной массы в процессе послеуборочного хранения. Указаны основные реологические свойства перерабатываемого продукта и операции, необходимые для осуществления технологического процесса извлечения растительного масла.
The description of the technological scheme of processing of oil seeds with the use of newly developed equipment of the site of preparatory operations of the oil plant is proposed based on the analysis of machines and mechanisms used for the processing of oilseeds. The main types of oil raw materials, composition and preservation of seed mass in the process of postharvest storage were considered. The main rheological properties of the processed product and the operations necessary for the technological process of extracting vegetable oil are indicated.
PROJECT DEVELOPMENT OF THE NATIONAL STANDARD ON QUALITY CONTROL AND IDENTIFICATION OF THE CHEWING TOBACCO
Authors: САМОЙЛЕНКО Н.П. , КАНДАШКИНА И.Г. , ГНУЧИХ Е.В. , МИРНЫХ Л.А. 
Published: November 2021

Рассмотрены идентификационные признаки некурительных табачных изделий табака жевательного и снюса. Разработан метод определения фракционного состава табака жевательного. На основании научных исследований впервые разработан проект национального стандарта ГОСТ Р Табак жевательный. Общие технические условия, который после утверждения и введения в действие будет использоваться для идентификации этого вида некурительной табачной продукции.
The identification signs of smokeless tobacco products: of chewing tobacco and snus are considered. A method for determining the fractional composition of chewing tobacco has been developed. On the basis of scientific research for the first time developed a draft national standard GOST R Chewing tobacco. General technical specifications. After approval and entry into force, this standard will be used to identify types of smokeless tobacco products.