bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antitumor Effect of Fluoxetine on Chronic Stress-Promoted Lung Cancer Growth via Suppressing Kynurenine Pathway and Enhancing Cellular Immunity
Authors: Yang Zhen , Li Zhuman , Guo Zhijun , Ren Yu , Zhou Ting , Xiao Zhijun , Duan Jingjing , Han Chuangchuang , Cheng Yuanchi , Xu Feng 
Published: August 2021

Background: Chronic stress promotes cancer growth. Antidepressant fluoxetine (FLX) is usually prescribed for cancer patients with comorbid depression. FLX displays inhibition on cancer cell proliferation, however, the in vivo activity has not been investigated.Methods: We explored the antitumor effect of FLX in subcutaneous transplanted lung cancer cells in a tumor-bearing mouse model. Fifty-six C57BL/6 mice were randomly divided into group A (blank control), group B (tumor-bearing control), group C (tumor-bearing + FLX), group D (CUMS control), group E (CUMS + FLX), group F (tumor-bearing + CUMS), and group G (tumor-bearing + CUMS + FLX). 5-HT, tryptophane (Trp), kynurenine, IFN-γ, TNF-α, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-17A levels were measured by ELISA. T helper (Th), cytotoxic T (Tc) and regulatory T cells (Tregs) subtype were measured by flow cytometry. The antitumor effects of FLX were evaluated by tumor weight. The expression of kynurenine pathway related genes TDO, IDO1, IDO2, and apoptosis-related genes caspase1, 3, 4, 5, 7, 12 in tumor tissues were measured by western blotting and qRT-PCR. A549 cells were exposed with FLX (15 μmol/L) and its effect on cell proliferation, migration, and clonal formation were detected. Kynurenine pathway and apoptosis related gene expression were also measured.Results:In vivo, chronic stress promoted tumor growth in C57BL/6 mice. FLX administration not only significantly reversed chronic unpredictable mild stress (CUMS)-induced reduction of 5-HT and Trp, increment of kynurenine, but increased CD4+ Th and CD8+ Tc cells, and reduced CD25+ FOXP3+ Tregs. FLX promoted Th to differentiate into Th1 cells and increased IL-2 and IFN-γ, meanwhile inhibited Th differentiate into Th2 and Th17 cells and decreased the concentrations of IL-4, IL-6, IL-10, and IL-17A. Chronic stress obviously up-regulated IDO1 and IDO2 expression, down-regulated caspase 4, 7, and 12 expression, meanwhile FLX administration reversed this regulation. However, there was no significant change in TDO, caspase 1, 3, 5. Similarly, in vitro, FLX administration significantly inhibited the proliferation, migration, and clonal formation of A549 cells and induced cell apoptosis. FLX administration down-regulated the expression of IDO1, IDO2, and up-regulated caspase 4, 5, and 7.Conclusion: Fluoxetine administration could inhibit tumor growth. The inhibition might be via suppressing kynurenine pathway and enhancing cellular immunity.
ZnT8 Deficiency Protects From APAP-Induced Acute Liver Injury by Reducing Oxidative Stress Through Upregulating Hepatic Zinc and Metallothioneins
Authors: Su Wen , Feng Mingji , Liu Yuan , Cao Rong , Liu Yiao , Tang Junyao , Pan Ke , Lan Rongfeng , Mao Zhuo 
Published: August 2021

Zinc transporter 8 (ZnT8) is an important zinc transporter highly expressed in pancreatic islets. Deficiency of ZnT8 leads to a marked decrease in islet zinc, which is thought to prevent liver diseases associated with oxidative stress. Herein, we aimed to investigate whether loss of islet zinc affects the antioxidant capacity of the liver and acute drug-induced liver injury. To address this question, we treated ZnT8 knockout (KO) or wild-type control mice with 300 mg/ kg acetaminophen (APAP) or phosphate-buffered saline (PBS). Unexpectedly, we found that loss of ZnT8 in mice ameliorated APAP-induced injury and was accompanied by inhibition of c-Jun N-terminal kinase (JNK) activation, reduced hepatocyte death, and decreased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). An increase in hepatic glutathione (GSH) was observed, corresponding to a decrease in malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) levels. APAP-induced inflammation and glycogen depletion were alleviated. In contrast, no significant changes were observed in cytochrome P450 family 2 subfamily E member 1 (CYP2E1), the main enzyme responsible for drug metabolism. Elevated levels of hepatic zinc and metallothionein (MT) were also observed, which may contribute to the hepatoprotective effect in ZnT8 KO mice. Taken together, these results suggest that ZnT8 deficiency protects the liver from APAP toxicity by attenuating oxidative stress and promoting hepatocyte proliferation. This study provides new insights into the functions of ZnT8 and zinc as key mediators linking pancreatic and hepatic functions.
Sleep-Wake Behavior in Elite Athletes: A Mixed-Method Approach
Authors: de Blasiis Kévin , Joncheray Hélène , Elefteriou Julia , Lesenne Chloé , Nedelec Mathieu 
Published: August 2021

PurposeUsing a mixed-method approach, this investigation aimed to examine athletes’ sleeping patterns along with the socio-physiological acute and chronic stressors affecting their sleep.MethodsFifteen elite athletes (Mage = 21.7 years; SD = 2.2) were monitored daily during a typical in-season training period (20 ± 1 days) and completed individual semi-structured interviews. Their sleep was analyzed using actigraphy and sleep diaries. A content analysis method was used to assess qualitative interviews.ResultsThree factors influencing sleep emerged from the qualitative interview analyses, i.e., sleep environment, training and study requirements. Half the athletes (8/15) complained about their sleeping environment with noise and/or bedroom temperature and/or mattress quality and/or light exposure presented as an issue. “Complainers” notably exhibited impaired (p &lt; 0.05) sleep efficiency and wake after sleep onset compared with “non-complainers.” Daily training load showed correlations (p &lt; 0.05) with wake after sleep onset and sleep onset latency. “Student athletes” exhibited later bedtime and earlier wake-up time compared with “non-student athletes,” leading to a reduced total sleep time (6:50 ± 1:13 vs. 7:06 ± 0:53; p &lt; 0.05; d = 0.20).ConclusionAn individualized assessment of sleep using actigraphy and interviews, with consideration to various socio-physiological factors, is recommended. Individualized sleep interventions with consideration to physiological (e.g., training load), behavioral (e.g., screen use) and environmental factors (e.g., room temperature, noise, mattress), can then be provided to each athlete.
NEW RULES AND THOLKAAPPIYA RULES IN NANNUL GRAMMAR
Authors: Devi Manonmani 
Published: August 2021

Next to the canonical Tholkaappiyam, the book entitled 'Nannool' stands out as the one that closely follows the Tamil grammatical tradition. This book can be considered as a sequel to the 'Tholkaappiyam' with respect to the rudimentary Tamil grammar rules used, though some of which have been omitted over the years, with some improvisations added. 'Nannool' has fine-tuned some aspects which Tholkaappiyam had eleborated in detail to an easier & simplified version of understanding and at the same time consolidated the grammar knowledge within it. The 'word punarchi' rules found in 'Nannool' along with the new added-on 'word punarchi' rules not mentioned in Tholkaappiyam are looked at closely and reviewed in detail in this study. This is the primary aim of this study.
SUJATHA'S WORKS ON THE BACKGROUND OF LANGUAGE
Authors: Barvin Jainambu , Anwar Mohamed 
Published: August 2021

The purpose of this study is to explore the innovations that creator Sujatha has used in her works and that she has some unique identities in handling language. The explanatory approach approach has been handled based on the thread study of this study. The researcher confirms that Sujatha is also a great creator in the world of Tamil literature. Creators use many elements in their work to convey to the reader the emotions they have received. The creator can be identified by examining those elements. The study aims to identify her uniqueness in Sujatha's work. In Sujata's works, the language structure is better than the plot. His essence has been adopted by later literary men as well. I am learning a lot from Sujatha in the post-modernist Charu Nivedita uirmai magazine. Also says my teacher (p.43). S. Ramakrishnan says of Sujatha's "chopped verses are a forerunner to those like me today".
Flash lamp annealing processing to improve the performance of high-Sn content GeSn n-MOSFETs
Authors: Oka Hiroshi , Mizubayashi Wataru , Ishikawa Yuki , Uchida Noriyuki , Mori Takahiro , Endo Kazuhiko 
Published: August 2021

Abstract
This paper describes the use of flash lamp annealing (FLA) to fabricate high-Sn content GeSn n-MOSFETs. We exploit FLA processing for both impurity activation and for the solid-phase growth (SPG) of the GeSn channel. High-Sn incorporation of up to 12% is achieved by overcoming the solid-solubility limit of Sn in Ge (1%), and high-quality n+-source/drain junctions were obtained by P implantation and subsequent FLA. Consequently, we achieved well-behaved transistor operation of the SPG-Ge0.88Sn0.12 n-MOSFETs, with an on/off current ratio one order of magnitude higher than for conventional rapid thermal annealing processing.
Penguatan Sektor Mikro terhadap Pembiayaan Al-Qardh Al-Hasan di Bank Syariah Mandiri Cabang Lombok Timur
Authors: Isniarti Baiq 
Published: August 2021

Referring to the economy of West Nusa Tenggara Province, East Lombok Regency is an area that is considered very suitable for the development of UMKM. There are several reasons that can be put forward, including the very weak economic condition of the community and the very dense population growth according to the community to find their own business to fulfill their daily needs. With this situation, UMKM based businesses have more potential than industrial-based economic business activities. In addition, the socio-religious factors of the community, the majority of which are Muslim, are 90%, as well as the large number of religious educational institutions such as Islamic boarding schools and madrasas that create religious emotional closeness so that they can use Islamic bank products, particularly al-Qardh al-Hasan financing for the development of small and micro businesses. The author can formulate the problem in this study as follows: a) How is the implementation of al-Qardh al-Hasan financing at PT. East Lombok Branch of Bank Syariah Mandiri for UMKM?, b) How is the contribution of al-Qardh al-Hasan financing to the strengthening of Micro Enterprises in East Lombok Regency? This research is a field research, The nature of descriptive research. The implementation of Qardhul Hasan financing at Bank Syariah Mandiri East Lombok Branch is applied in a program called the Umat Partner Program namely: Community Education Program (Economic Empowerment) and Sympathy People (Social Concern), in its development includes productive and consumptive economic activities, social community including education, health. Broadly speaking, this program is divided into economic empowerment activities (manifested in the form of providing Qardhul Hasan loans in the form of business or investment and consumptive capital) and social activities (donations). In the process of implementing this financing, Bank Syariah Mandiri East Lombok Branch provides many conveniences, especially in the process of submitting and paying installments, so that customers feel comfortable with this financing service. And the contribution of Qardhul Hasan funds for micro-businesses customers is an increase in income which is an average of Rp. 400,000, - or about 66%. This increase in income has an effect on the increase in net income (after installments deducted) for customers who previously only earned an average income of Rp. 505,000, - to an average of Rp. 775,000, - per month. With an increase in operating income by 66%, it means that Qardhul Hasan financing has contributed Rp. 235,000, - or 18% for the poor to be above the poverty line.
Germas Covid-19 Bersama Ibu-Ibu Warga Dusun Ireng Lauk Desa Jatisela
Authors: Nofisulastri Nofisulastri , Nurdin Nurdin 
Published: August 2021

Wabah virus Covid-19 telah menjadi pandemic dunia dan memasuki Indonesia sekitar awal tahun 2020. Langkah-langkah penanggulangan terpadu termasuk keterlibatan seluruh komponen masyarakat perlu dilakukan dengan menggali potensi yang dimiliki masyarakat agar berdaya dan mampu berperan serta mencegah penularan Covid-19. Bentuk Pendekatan kesehatan masyarakat yang dapat dilakukan berupa kegiatan GERMAS melalui pendekatam keluarga. Kegiatan pengabdian ini merupakan bentuk sinergitas kegiatan KAGAMA NTB dengan melibatkan dosen Undikma untuk memberikan sosialisasi terkait Covid-19 dan GERMAS mencuci tangan dan hidup sehat. Tahapan kegiatan pengabdian masyarakat ini dilaksanakan tertanggal 11 sampai dengan 25 April 2020 meliputi communication, design, execution, dan disseminate. Sasaran kegiatan adalah ibu-ibu PKK perwakilan dusun Ireng Lauk sebanyak 10-15 orang. Kegiatan pengabdian dilaksanakan beberapa sesi yaitu sesi sosialisasi materi, sesi pelatihan GERMAS (gerakan mencuci tangan sehat dan senam imun), sesi tanya jawab dan quiz berhadiah, dan diakhiri penutupan berupa senam bersama dan pembagian souvenir. Kegiatan berlangsung cukup lancar dengan antusiasme peserta yang melebihi permintaan dan kegiatan berlangsung waktu yang cukup panjang pada sesi tanya jawab.
Workshop Evaluasi Terhadap Sekolah Khusus Olahragawan PPLP NTB
Authors: Soemardiawan Soemardiawan , Yundarwati Susi 
Published: August 2021

Workshop evaluasi terhadap sekolah khusus olahragawan PPLP NTB, PPLP NTB merupakan salah satu wadah untuk atlet di Nusa Tenggara Barat. Sekolah ini didirikan sebagai wahana Training Center calon atlet agar memiliki prestasi yang memuaskan, baik di tingkat nasional maupun internasional. Metode yang diterapkan dalam kegiatan ini adalah Desain evaluasi menggunakan model CIPP (Contex, Input, Proces, dan Product) yang dikembangkan oleh Stufflebeam (1985). Model ini memiliki kelebihan dibandingkan model lainnya karena dapat melihat keberhasilan program secara lebih komprehensif, tidak hanya melihat keberhasilan program dari tujuan semata, tetapi mulai dari konteksprogram, input, proses, dan produk secara menyeluruh. Metode yang digunakan dalam pengumpulan data berupa: angket, wawancara dan dokumentasi. Metode ini digunakan untuk menggali data (indepht) yang lebih mendalam yang tidak diperoleh dari pertanyaan dalam angket. Wawancara ditujukan kepada kepala sekolah, pelatih, guru, alumni, dan siswa guna melengkapi data yang digunakan dalam angket. Dokumentasi digunakan untuk menjaring data, meliputi: latar belakang (karakteristik) pelatih, guru, data nilai akhir ujian nasional siswa, prestasi olahraga yang diraih atlet, latar belakang siswa (cabang olahraga, asal daerah). Hasil akhir dari kegiatan penelitian pengabdian ini adalah sebagai wahana Training Center calon atlet agar memiliki prestasi, pembangunan bidang olahraga dilaksanakan melalui berbagai program kegiatan, baik yang bersifat olahraga massal, pembibitan, maupun prestasi. Untuk mendorong keberhasilan olahraga ditanah air, pemerintah telah memberikan kesempatan dan layanan pendidikan kepada segenap pemuda untuk mengikuti pendidikan olahraga bagi yang memiliki bakat olahraga melalui sekolah atlet sekolah khusus olahragawan PPLP NTB didaerah mataram yaitu jalan Pemuda Gomong Mataram.
Pelatihan Dan Pendampingan Guru Di MGMP Matematika Sumbawa Besar Tentang Bertanya Produktif Dalam Pembelajaran Matematika
Authors: Juliangkary Eliska , Sanapiah Sanapiah , Yuliyanti Sri , Pujilestari Pujilestari , Kurniawan Ade , Muzaki Ahmad , Nurdin Nurdin 
Published: August 2021

Salah satu upaya yang dapat dilakukan untuk meningkatkan interaksi pada pelajaran matematika antara guru dan siswa di kelas adalah dengan meningkatkan komunikasi verbal diantara keduanya. Komunikasi verbal ini dapat dilakukan melalui aktivitas bertanya. pertanyaan produktif memiliki ciri tersendiri. pertanyaan produktif memperoleh jawaban dari pengalaman langsung, menyadarkan siswa bahwa sebuah pertanyaan tidak mustahil memberikan beberapa jawaban yang benar, serta mendorong siswa bahwa pertanyaan dapat dijawab oleh semua siswa, bukan hanya oleh siswa yang pandai saja. Tujuana dilakukannya kegiatan ini adalah agar peserta kegiatan ini mampu: 1) Untuk mendiskusikan tujuan dari bertanya produktif dalam pelajaran matematika. 2) Untuk mendiskusikan teknik bertanya produktif yang mendorong belajar dalam pelajaran matematika. 3) Untuk mengembangkan pemahaman guru mengenai karakteristik dari pertanyaa produktif dalam pembelajaran matematika. 4) Untuk mengidentifikasi pertanyaan produktif yang disajikan melalui video klip dan Rencana Pelaksanaan Pembelajaran (RPP). Manfaat kegiatan ini adalah guru-guru dapat mengembangkan kualitas dalam mengajar matematika, khususnya kualitas guru mengembangkan pertanyaan produktif yang dapat digunakan dalam pembelajaran matematika di kelas
Pengaruh Literasi Sains, Pemahaman Qur’an Hadist Dan Kecerdasan Naturalis Terhadap Sikap Peduli Lingkungan
Authors: Suhirman Suhirman 
Published: August 2021

Tujuan penelitian ini untuk mengetahui pengaruh literasi sains, pemahaman Quran-hadis, dan kecerdasan naturalis terhadap sikap peduli lingkungan siswa madrasah tsanawiyah di Kota Mataram. Populasi dalam penelitian ini adalah seluruh siswa madrasah tsanawiyah di Kota Mataram kelas IX tahun pelajaran 2019/2020 yang berjumlah 1.440 orang. Sampel ditentukan dengan metode cluster random sampling. Penelitian ini melibatkan empat variabel yakni tiga variabel bebas: literasi sains, pemahaman Quran hadis dan kecerdasan naturalis dan satu variabel terikat yakni sikap peduli. Literasi sains, pemahaman Quran hadis dan kecerdasan naturalis dikumpulkan dengan instrument soal tes dan variabel sikap peduli lingkungan dikumpulkan dengan instrumen angket. Data dianalisis dengan menggunakan teknik statistik deskriptif dan statistik inferensial. Uji hipotesis menggunakan analisis regresi linear dan uji F untuk melihat pengaruh kumulatif variabel bebas (X1, X2, X3) terhadap variabel terikat (Y). Hasil penelitian menunjukkan Level literasi sains siswa MTs Kota Mataram termasuk katagori rendah. Walaupun demikian, literasi sains berpengaruh positif signifikan terhadap sikap peduli lingkungan siswa MTs di Kota Mataram. Pemahaman Quran Hadis siswa MTs Kota Mataram termasuk katagori sedang. Pemahman Quran Hadis berpengaruh positif tidak signifikan terhadap sikap peduli lingkungan siswa MTs di Kota Mataram. Kecerdasan naturalis siswa MTs Kota Mataram termasuk katagori tinggi. Kecerdasan naturalis berpengaruh negatif signifikan terhadap sikap peduli lingkungan siswa MTs di Kota Mataram. Literasi sains, pemahaman Quran Hadis, dan kecerdasan naturalis berpengaruh positif signifikan bersama-sama terhadap sikap peduli lingkungan siswa MTs di Kota Mataram. Pembelajaran qur’an-hadist dan sains tentang lingkungan hidup seharusnya diimbagi dengan penerapannya dalam kehidupan nyata
CARA KERJA ILMU SOSIAL AGAR SEHANDAL DAN SEHEBAT ILMU ALAM
Authors: Faqih Muhammad 
Published: August 2021

Kehebatan dan kehandalan ilmu alam dalam memecahkan masalah alam terbukti handal dan terus berkembang. Hal ini tidak terjadi pada ilmu sosial. Banyak persoalan sosial yang tidak dapat dipecahkan oleh ilmu sosial. Para ilmuwan tergoda menggunakan model kerja ilmu alam seperti Auguste Comte yang menjadikan Sosiologi sebagai fisika sosial. Husni Muadz (2016) membuat model sosial ideal dengan cara berpikir deduktif melalui pendekatan filosofis – teoritis. Tujuan dari kajian ini adalah untuk membangun model sosial ideal dengan pendekatan agama melalui cara berpikir induktif. Hasil penelitian menemukan hukum yang berlaku pada dunia sosial dan cara kerja ilmu sosial di masa depan agar sehandal ilmu alam.
Penentuan Kadar Logam Tembaga pada Perairan dan Sedimen di Limbah Pertambangan Tradisional Desa Perabu Kabupaten Lombok Tengah
Authors: Firmansyah Dodiy , Sustiyani Elly 
Published: August 2021

. Prabu’s people in central Lombok regency make traditional mining for their livelihood. Coppers are one of the wastes from traditional mining, which is dumped into rivers can pollute the waters used by humans a source of clean water. Heavy metals in biota consumed by humans and transmit various diseases, This research to determination copper compound in waters and sediments. The are two puposes of this reseach: (1) to determine coppers in waters and sediments, and (2) to determine copper compound. There are three steps of this reseach: (1) conducting sampling, (2) pretreatment of sediment samples, (3) determining heavy metal levels with the fraction 1 stepwise extraction method (ELFE), and (4) analyzing copper compound . The result showed that copper compound increasing in locations B and C, contain 0.065 mg / L and 0.051 mg / L in water and contain 89 mg/kg, 85 mg/kg in sediment
Pengembangan Permainan Bola Besar (Bolavoli) Berbasis Problem Based Learning Untuk Meningkatkan Minat Belajar Peserta Didik Putri
Authors: Kurniawan Susetya Kukuh , Rachman Abdul , Indahwati Nanik 
Published: August 2021

. Setiap peserta didik berhak mendapatkan pendidikan yang baik, sebab pendidikan selalu berkembang dan meningkat setiap masanya. Pendidikan sendiri memiliki peran yang sangat vital bagi peserta didik salah satunya pendidikan jasmani olahraga kesehatan (PJOK). PJOK memiliki tujuan yaitu meningkatkan potensi fisik peserta didik, membudayakan sportivitas, dan budaya hidup sehat, maka dari itu perlu kita buat pembelajaran Pendidikan Jasmani Olahraga Kesehatan yang nyaman dan bisa tercapai tujuan-tujuan tersebut. Oleh karena itu dibutuhkan dalam penyusunan atau stategi pembelajran yang menarik agar tujuan tersbut tercapai. Maka dari itu, Penelitian ini bertujuan untuk menghasilkan perangkat pembelajaran pendidikan jasmani permainan bola besar berbasis Problem Based Learning(PBL) meningkatkan minat belajar peserta didik khususnya putri. Rancangan yang digunakan dalam penelitian ini adalah rancangan penelitian dan pengembangan (research & development) mengacu pada model ADDIE singkatan dari Analysis, Design, Development, Implementation and Evaluations. Dalam penelitian ini karena bersamaan dengan masa pandemic maka diterpakan dengan penerpan elearning dalam upaya meningkatkan minat belajar peserta didik kususnya putri. Dalam penelitian ini terdapapan pengembang RPP, LKPD dan angket respon guru, anket minat belajar peserta didik dan ketrampilang pasing bawah bolavoli. Hasil pengembangan permaina bola besar berbasis problem based learning berbasis untuk meningkatkan minat belajar peserta didik putri adalah sebagai berikut pelaksanaan pembelajaran terlaksana baik dengan nilai 80,4%, respon guru sangat baik dan pendapat sangat mendukung,keterampilan pasing bawah bolavoli peserta didik kuat mencapai 78,6% dan minat belajar kuat dengan nilai 75,05%. Produk pengembangan permainan bola besar (bolavoli) berbasis problem based learning sangat baik bagi peserta didik putri untuk meningkatkan minat belajar.