bluuebunny/crossref_metadata_2025_split huggingface dataset:
Juegos de perspectivas: historia y ficción en "El viento de la luna" de A. Muñoz Molina
Authors: Fiordaliso Giovanna 
Published: March 2021

Este trabajo analiza El viento de la luna, novela de 2006 de Muñoz Molina: es la historia de un chico de trece años que vive en Mágina, pequeña ciudad de provincia y que, fascinado por la misión espacial del Apolo XI y por las aventuras de su comandante, Neil Armstrong, asiste, más o menos consciente, al nacimiento de una nueva época. A través del punto de vista del protagonista, la realidad histórica de 1969 adquiere matices privados; al mismo tiempo, el cruce de miradas entre tierra y luna va a desempeñar un papel esencial en la novela, que se convierte en un canto de amor del autor hacia su país y hacia la literatura, fuente de consolación y sentido último de las experiencias.
This work analyses the novel El viento de la luna, published in 2006 by Muñoz Molina: it is the story of a thirteen-year-old boy who lives in Mágina, fascinated by the Apollo XI space mission and by the adventures of its commander, Neil Armstrong. Through his point of view, the historical reality of 1969 acquires private nuances. At the same time, the exchange of the perspective between earth and moon plays an essential role in the novel, which becomes in this way a song of love of the author towards his country and towards literature, the real consolation and meaning of experiences.
Des outils méthodologiques pour un enseignement critique du droit : revisiter la résidence familiale à partir d’une approche féministe historique
Authors: Laperrière Marie-Neige 
Published: March 2021

Dans le présent texte, l’autrice propose l’utilisation d’une approche féministe historique pour un enseignement critique du droit. Après avoir exposé les spécificités de cette approche, elle utilise l’exemple de la résidence familiale et les luttes féministes qui l’entourent pour offrir un exemple concret de son application dans l’enseignement d’un cours de droit de la famille.
Petit guide pratique sur l’approche féministe historique en cinq points :
The Constitution of Algorithms
Authors: Jaton Florian 
Published: March 2021

A laboratory study that investigates how algorithms come into existence.
Algorithms—often associated with the terms big data, machine learning, or artificial intelligence—underlie the technologies we use every day, and disputes over the consequences, actual or potential, of new algorithms arise regularly. In this book, Florian Jaton offers a new way to study computerized methods, providing an account of where algorithms come from and how they are constituted, investigating the practical activities by which algorithms are progressively assembled rather than what they may suggest or require once they are assembled.
Drawing on a four-year ethnographic study of a computer science laboratory that specialized in digital image processing, Jaton illuminates the invisible processes that are behind the development of algorithms. Tracing what he terms a set of intertwining courses of actions sharing common finalities, he describes the practical activity of creating algorithms through the lenses of ground-truthing, programming, and formulating. He first presents the building of ground truths, referential repositories that form the material basis for algorithms. Then, after considering programming's resistance to ethnographic scrutiny, he describes programming courses of action he attended at the laboratory. Finally, he offers an account of courses of action that successfully formulated some of the relationships among the data of a ground-truth database, revealing the links between ground-truthing, programming, and formulating activities—entangled processes that lead to the shaping of algorithms. In practice, ground-truthing, programming, and formulating form a whirlwind process, an emergent and intertwined agency.
The open access edition of this book was made possible by generous funding from Arcadia – a charitable fund of Lisbet Rausing and Peter Baldwin.
Analysis of Covariance of Gleason Score: A Case Study of 100 Prostate Cancer Patients Undergoing Treatment at the University of Port Harcourt Teaching Hospital, Rivers State, Nigeria
Authors: Ligeiaziba Sylva , Ijoma Maxwell A. , Biu Emmanuel I. 
Published: March 2021

Prostate cancer is the second most common cause of cancer related deaths in men. It is detected using many screening methods. Like every other cancer, there are risk factors associated with prostate cancer. This include but not limited to, Family History (FH) of the disease, smoking habit, alcohol intake, age and Body Mass Index (BMI). The survival of prostate cancer patients is dependent on many factors such as, early detection of the disease, age of patient and the aggressiveness of the cancer. Gleason score is used to measure the level of aggressiveness of a prostate cancer in a patient. the score ranges from 6 to 10. It is made up of two Gleason grades that ranges from 3 to 5. This study was carried out to determine whether there are significant differences in the mean of Gleason score by the various categories of BMI and FH of patients while controlling for the number of hospital visits. Gleason score was used as the dependent variable while FH and BMI and Number of hospital visits were used as the independent variables. Descriptive statistical measures were used to summarize the basic features of the data. Spearman correlation coefficient was used to measure if there is a significant statistical relationship between the Gleason score, age and BMI, while Analysis of Covariance (ANCOVA) was used to measure the differences in the mean of Gleason score by the categories of FH and BMI while controlling for number of hospital visits. The analysis was done using Statistical Programme for Social Science (SPSS 25.0) and Intellectus Statistics software. Results from the analyses were presented in tabular form. The results showed a significant effect of Body Mass Index (BMI) on Gleason score and that Gleason score increases, as age tends to increase.
Investigating the Level of the Tenth-grade Students’ Self-Efficacy in Mathematics and its Impact on their Performance: A Study in Pemagatshel District
Authors: Norbu Pema , Dukpa Pema 
Published: March 2021

The study aimed at finding out the level of Mathematics self-efficacy and its relationship with the Mathematics performance of tenth-grade students. The study used a quantitative method. The data was collected from one middle secondary school and three central schools under the Pemagatshel district from 3rd March to 16th March 2020. A total of 300 students comprising 150 males and females each were included for the study. The data was collected using Mathematics Self-Efficacy Scales and analyzed using SPSS. The overall finding indicated that students had an average level of Mathematics self-efficacy (M=3.25; SD= 0.60). Among the four sources of self-efficacy, the study revealed that the students had high Mathematics self-efficacy in vicarious experience (M= 3.67; SD= 0.62). The Pearson correlation indicated a moderate positive correlation (r= .467, P=.05) between Mathematics self-efficacy and Mathematics performance. Higher the Mathematics self-efficacy, better the Mathematics performance, and lower the Mathematics self-efficacy, poorer the Mathematics performance. Therefore, it is imperative to strengthen the skills and strategies that enhance the Mathematics self-efficacy of the students.
Evaluation of Psychiatric Disorders in Spouse of Patients with Alcohol Dependence Syndrome
Authors: Tilwani Mahesh 
Published: March 2021

Background and Aim: Alcohol Dependence Syndrome has deleterious consequences not only on the patient with Alcohol Dependence Syndrome but also on the members of his family. The psychopathology in wives of patients with Alcohol Dependence Syndrome is a largely neglected area in psychiatric research. Aim of the present study was to evaluate the frequency and nature of psychiatric disorders in wives of patients with Alcohol Dependence Syndrome.
Materials and Methods: A total of 177 wives, 100 wives of patients with Alcohol Dependence Syndrome and 77 wives of patients with Bipolar Affective Disorder- current episode mania were evaluated. Tools used were ICD-10 AM symptom checklist and modules for assessment of psychiatric morbidity and diagnosis was made based on The International Classification of Diseases – (Diagnostic Research Criteria DCR-10).
Results: Psychiatric disorders are diagnosed in 75% of the wives of patients with alcohol dependence syndrome out of which 45% have dysthymia, 12% have mild depressive episode, 8% have adjustment disorder- prolonged depressive reaction, 5% have moderate depressive episode and 5% have anxiety disorder unspecified.
Conclusion: The present study concludes that the wives of patients with Alcohol Dependence Syndrome have significant psychiatric morbidity when compared to wives of patients with Bipolar Affective Disorder-current episode mania. The most common psychiatric disorder is dysthymia.
Immobilization Potential of Cow Manure for Heavy Metal Remediation from Refuse Dump Soil
Authors: Christian Ezeudu Emeka , Chukwuemeka Oli Christian , Enenche . , Daniel Elaigwu , Juliana Anekwe Ozioma , Chudi Okoye Patrice-Anthony , Egbulefu Ajiwe Vincent Ishmael 
Published: March 2021

Aims: The present study investigated the effect of cow manure amendment on fractionation and availability of some heavy metals (Cd, Cu, Cr, Mn, Pb and Zn) in refuse dump soil.
Study Design: A greenhouse study experiment was conducted to determine the uptake of the metals by Ricinus communis in dump soil treated with 0%, 5%, 10% and 20% cow manure.
Place and Duration of Study: The study was carried out at the Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University Awka, Anambra State, Nigeria, between May and October 2018.
Methodology: Experimental pots were filled with 2.0kg refuse dump soil in a green house and treated with 5%, 10% and 20% of Cow manure in three replicates per treatment. The seeds of Ricinus communis were planted in each pot and analysed after 12 weeks of planting for heavy metals using AAS. Sequential extraction was carried out on the treated soil after the harvest with each extract further analysed for heavy metals using AAS.
Results: Application of cow manure significantly (p ˂ 0.05) affected the redistribution and the mobility of the heavy metals in the dump soil; as the concentration of the amendment increased, heavy metals in the mobile fractions reduced. 20% amendment had the best immobilization effect as the mobility factor decreased with increasing manure amendment. The mobility factors at 20% amendment were 18.34%, 15.82%, 5.23%, 15.86%, 25.56% and 12.81% for Cd, Cr, Cu, Mn, Pb and Zn respectively with the general trend of metal forms given as: residual > bound to organic > bound to Fe-Mn oxide > bound to carbonate > exchangeable.
Conclusion: Cow manure amendment of the dump soil decreased the availability of heavy metals for plant uptake; and the metal uptake generally decreased as percentage amendment increased. Cow manure is therefore a good immobilizing agent for remediation of Cd, Cr, Cu, Mn, Pb and Zn in polluted soils.
Pharmacokinetics Evaluation of Acamprosate Tablets in Healthy Human Volunteers
Authors: Chaudhari Kiran S. , Bagul Milind , Shah Ketan 
Published: March 2021

Pharmacokinetic data of acamprosate tablets was not accessible on large number of human. Rationale to examine the pharmacokinetic properties of acamprosate calcium in healthy male subject, on single or multiple dosage administration, to evaluate the bioequivalence of two formulations of acamprosate calcium tablets in fast or fed environment. This work engross the study of pharmacokinetic property of Acamprosate calcium tablets in single dosing under fasting condition.
Methods: Bioequivalence study of delayed release acamprosate tablets 333 mg for a randomized, single dose, open label, two treatment, two periods, two sequences and crossover design in 12 healthy, adult human subjects under fasting condition was conducted. The wash out period within the each treatment and each stage was 1 week. The quantification of acamprosate was done by LCMS/MS method. Accessibility was evaluated by monitoring adverse events, physical examinations and ECG and laboratory tests.
Results: The entire study was conducted by using 12 male subjects to fulfill all stages in the study. The pharmacokinetic calculations for test and reference formulations are as follows: single dosing, Tmax 8.54 ± 5.24 and 10.71 ± 5.41 h, Cmax 146.06 ± 99.73 and 115.01 ±86.26 ng · mL−1, AUC0-t 1391.95 ± 731.24 and 1557.03 ± 960.98 ng·mL−1·h, AUC0–∞ 1987.40 ± 962.84 and 2720.21 ± 1931.79 ng·mL−1·h, respectively. In all three stages, 90% CIs for the test/reference ratio of AUC0–t and AUC0–∞ was to be found within 80% –125% of acamprosate calcium.
Conclusions: As per regulatory guidelines, pharmacokinetics parameters for acamprosate calcium were found to be within the acceptance criteria.
PAPP‐A functions as a tumor suppressor and is downregulated in renal cell carcinoma
Authors: Lu Yanxin , Li Shi , Wang Tongyu , Liao Ximian , Mao Longyi , Li Zesong 
Published: March 2021

Pregnancy‐associated plasma protein A (PAPP‐A) is a proteolytic enzyme produced by the placenta. The expression and role of PAPP‐A in renal cell carcinoma (RCC) remain elusive. The aim of this study was to investigate the role and the molecular mechanisms of PAPP‐A in RCC. Initially, we evaluated the expression of PAPP‐A in samples from patients with RCC and cell lines by quantitative PCR, western blot and immunohistochemical staining, and examined the role of PAPP‐A in RCC cells by cell viability, colony formation and Transwell assays. Next, we investigated the molecular mechanisms regulating the tumor suppressor function of PAPP‐A. Our results demonstrated that PAPP‐A is expressed at low levels in RCC tissues and cells. Clinical data analysis revealed a significant correlation between PAPP‐A expression and RCC‐related death (P < 0.0115). Overexpression of PAPP‐A inhibited viability, proliferation, migration and invasion of RCC cells. Furthermore, PAPP‐A overexpression significantly increased phosphorylation of c‐Jun N‐terminal kinase and decreased the expression of cyclin D1, phosphorylated glycogen synthase kinase‐3β and β‐catenin. This study is the first to report that downregulation of PAPP‐A is associated with poor prognosis in patients with RCC. In conclusion, PAPP‐A may serve as a novel prognostic marker and potentially as a therapeutic target in patients with RCC.
A connectome‐based approach to assess motor outcome after neonatal arterial ischemic stroke
Authors: Al Harrach Mariam , Pretzel Pablo , Groeschel Samuel , Rousseau François , Dhollander Thijs , Hertz‐Pannier Lucie , Lefevre Julien , Chabrier Stéphane , Dinomais Mickael ,   the AVCnn study group
Published: March 2021

AbstractObjectiveStudies of motor outcome after Neonatal Arterial Ischemic Stroke (NAIS) often rely on lesion mapping using MRI. However, clinical measurements indicate that motor deficit can be different than what would solely be anticipated by the lesion extent and location. Because this may be explained by the cortical disconnections between motor areas due to necrosis following the stroke, the investigation of the motor network can help in the understanding of visual inspection and outcome discrepancy. In this study, we propose to examine the structural connectivity between motor areas in NAIS patients compared to healthy controls in order to define the cortical and subcortical connections that can reflect the motor outcome.MethodsThirty healthy controls and 32 NAIS patients with and without Cerebral Palsy (CP) underwent MRI acquisition and manual assessment. The connectome of all participants was obtained from T1‐weighted and diffusion‐weighted imaging.ResultsSignificant disconnections in the lesioned and contra‐lesioned hemispheres of patients were found. Furthermore, significant correlations were detected between the structural connectivity metric of specific motor areas and manuality assessed by the Box and Block Test (BBT) scores in patients.InterpretationUsing the connectivity measures of these links, the BBT score can be estimated using a multiple linear regression model. In addition, the presence or not of CP can also be predicted using the KNN classification algorithm. According to our results, the structural connectome can be an asset in the estimation of gross manual dexterity and can help uncover structural changes between brain regions related to NAIS.
Diminished muscle oxygen uptake and fatigue in spinal muscular atrophy
Authors: Montes Jacqueline , Goodwin Ashley M. , McDermott Michael P. , Uher David , Hernandez Feliz Marie , Coutts Kayla , Cocchi Julia , Hauschildt Margarethe , Cornett Kayla M. , Rao Ashwini K. , Monani Umrao R. , Ewing Garber Carol , De Vivo Darryl C. 
Published: March 2021

AbstractObjectiveTo estimate muscle oxygen uptake and quantify fatigue during exercise in ambulatory individuals with spinal muscular atrophy (SMA) and healthy controls.MethodsPeak aerobic capacity (VO2peak) and workload (Wpeak) were measured by cardiopulmonary exercise test (CPET) in 19 ambulatory SMA patients and 16 healthy controls. Submaximal exercise (SME) at 40% Wpeak was performed for 10 minutes. Change in vastus lateralis deoxygenated hemoglobin, measured by near‐infrared spectroscopy, determined muscle oxygen uptake (ΔHHb) at rest and during CPET and SME. Dual energy X‐ray absorptiometry assessed fat‐free mass (FFM%). Fatigue was determined by percent change in workload or distance in the first compared to the last minute of SME (FatigueSME) and six‐minute walk test (Fatigue6MWT), respectively.ResultsΔHHb‐PEAK, ΔHHb‐SME, VO2peak, Wpeak, FFM%, and 6MWT distance were lower (P < 0.001), and Fatigue6MWT and FatigueSME were higher (P < 0.001) in SMA compared to controls. ΔHHb‐PEAK correlated with FFM% (r = 0.50) and VO2peak (r = 0.41) only in controls. Only in SMA, Fatigue6MWT was inversely correlated with Wpeak (r = −0.69), and FatigueSME was inversely correlated with FFM% (r = −0.55) and VO2peak (r = −0.69).InterpretationThis study provides further support for muscle mitochondrial dysfunction in SMA patients. During exercise, we observed diminished muscle oxygen uptake but no correlation with aerobic capacity or body composition. We also observed increased fatigue which correlated with decreased aerobic capacity, workload, and body composition. Understanding the mechanisms underlying diminished muscle oxygen uptake and increased fatigue during exercise in SMA may identify additional therapeutic targets that rescue symptomatic patients and mitigate their residual disease burden.
Differences Sustained Between Diffuse and Limited Forms of Juvenile Systemic Sclerosis in an Expanded International Cohort
Authors: Foeldvari Ivan , Klotsche Jens , Kasapcopur Ozgur , Adrovic Amra , Terreri Maria Teresa , Sakamoto Ana Paula , Stanevicha Valda , Sztajnbok Flavio , Anton Jordi , Feldman Brian , Alexeeva Ekaterina , Katsicas Maria , Smith Vanessa , Avcin Tadej , Marrani Edoardo , Kostik Mikhail , Lehman Thomas , Sifuentes‐Giraldo Walter‐Alberto , Vasquez‐Canizares Natalia , Appenzeller Simone , Janarthanan Mahesh , Moll Monika , Nemcova Dana , Patwardhan Anjali , Santos Maria Jose , Sawhney Sujata , Schonenberg‐Meinema Dieneke , Battagliotti Cristina , Berntson Lillemor , Bica Blanca , Brunner Jürgen , Costa‐Reis Patricia , Eleftheriou Despina , Harel Liora , Horneff Gerd , Kaiser Daniela , Kallinich Tilmann , Lazarevic Dragana , Minden Kirsten , Nielsen Susan , Nuruzzaman Farzana , Uziel Yosef , Helmus Nicola , Torok Kathryn S. 
Published: March 2021

ObjectiveTo evaluate the baseline clinical characteristics of juvenile systemic sclerosis (SSc) patients in the international juvenile SSc inception cohort, and to compare these characteristics between the classically defined juvenile diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc) subtypes and among those with overlap features.MethodsA cross‐sectional study was performed using baseline visit data. Information on demographic characteristics, organ system evaluation, treatment, and patient‐ and physician‐reported outcomes was extracted and summary statistics applied. Comparisons between juvenile dcSSc and lcSSc subtypes and patients with and without overlap features were performed using chi‐square and Mann‐Whitney U tests.ResultsAt data extraction, 150 juvenile SSc patients were enrolled across 42 centers; 83% were White, 80% were female, juvenile dcSSc predominated (72%), and 17% of the cohort had overlap features. Significant differences were found between juvenile dcSSc and juvenile lcSSc regarding modified Rodnan skin thickness score, the presence of Gottron's papules, digital tip ulceration, results of the 6‐minute walk test, and composite pulmonary and cardiac involvement. All of these were more frequent in dcSSc except for cardiac involvement. Juvenile dcSSc patients had significantly worse scores for physician‐rated disease activity and damage. A significantly higher occurrence of Gottron's papules and musculoskeletal and composite pulmonary involvement, and a significantly lower frequency of Raynaud's phenomenon, were seen in those with overlap features.ConclusionResults from a large international juvenile SSc cohort demonstrate significant differences between juvenile dcSSc and juvenile lcSSc patients, including more globally severe disease and increased frequency of interstitial lung disease in juvenile dcSSc patients, while those with lcSSc have more frequent cardiac involvement. Those with overlap features had an unexpected higher frequency of interstitial lung disease.
Charge‐Conversion Strategies for Nucleic Acid Delivery
Authors: Dutta Kingshuk , Das Ritam , Medeiros Jewel , Kanjilal Pintu , Thayumanavan S. 
Published: March 2021

AbstractNucleic acids are considered as one of the most potent therapeutic modalities, as their roles go beyond storing genetic information and chemical energy or as signal transducers. Attenuation or expression of desired genes through nucleic acids have profound implications in gene therapy, gene editing, and even in vaccine development. Although nucleic acid therapeutics bring in overwhelming possibilities toward the development of molecular medicines, there are significant loopholes in their effective clinical translation. One of the major pitfalls lies in the traditional design concepts of nucleic acid drug carriers, namely, cationic charge induced cytotoxicity. Targeting this bottleneck, several innovative carrier designs have been proposed accommodating charge‐conversion approaches, whereby built‐in functionalities convert from cationic to neutral or anionic, or even from anionic to cationic enabling the carrier to overcome several critical barriers for therapeutics delivery, such as serum deactivation, instability in circulation, low transfection, and poor endosomal escape. This review will critically analyze various molecular designs of charge‐converting nanocarriers in a classified approach for the successful delivery of nucleic acids. Accompanied by the narrative on recent clinical nucleic acid candidates, the review concludes with a discussion on the pitfalls and scope of these emerging approaches.