bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermediate Renal Outcomes, Kidney Failure, and Mortality in Obese Kidney Donors
Authors: Ibrahim Hassan N. , Murad Dina N. , Hebert Sean A. , Adrogue Horacio E. , Nguyen Hana , Nguyen Duc T. , Matas Arthur J. , Graviss Edward A. 
Published: October 2021

Significance Statement
Obesity’s association with diabetes, hypertension, and possibly kidney disease has prompted concerns that these effects might be magnified after kidney donation in the donor’s remaining kidney. Half of US transplant centers exclude donation from kidney donor candidates who are obese. This comparison of mortality, kidney failure, proteinuria, diabetes, and hypertension in 6822 nonobese donors and 1761 obese donors showed that obesity in kidney donors, as in the general population, is associated with increased risk of developing diabetes, hypertension, and proteinuria. Mortality was similar between obese and nonobese donors. Absolute risk of ESKD was 0.5% in nonobese donors, 0.7% in obese donors, and 0.9% in very obese donors (body mass index <30 kg/m2, ≥30 kg/m2, or >35 kg/m2, respectively). Judicious acceptance of obese but otherwise healthy donor candidates should be considered.

Background
Obesity is associated with the two archetypal kidney disease risk factors: hypertension and diabetes. Concerns that the effects of diabetes and hypertension in obese kidney donors might be magnified in their remaining kidney have led to the exclusion of many obese candidates from kidney donation.

Methods
We compared mortality, diabetes, hypertension, proteinuria, reduced eGFR and its trajectory, and the development of kidney failure in 8583 kidney donors, according to body mass index (BMI). The study included 6822 individuals with a BMI of <30 kg/m2, 1338 with a BMI of 30–34.9 kg/m2, and 423 with a BMI of ≥35 kg/m2. We used Cox regression models, adjusting for baseline covariates only, and models adjusting for postdonation diabetes, hypertension, and kidney failure as time-varying covariates.

Results
Obese donors were more likely than nonobese donors to develop diabetes, hypertension, and proteinuria. The increase in eGFR in obese versus nonobese donors was significantly higher in the first 10 years (3.5 ml/min per 1.73m2 per year versus 2.4 ml/min per 1.73m2 per year; P<0.001), but comparable thereafter. At a mean±SD follow-up of 19.3±10.3 years after donation, 31 (0.5%) nonobese and 12 (0.7%) obese donors developed ESKD. Of the 12 patients with ESKD in obese donors, 10 occurred in 1445 White donors who were related to the recipient (0.9%). Risk of death in obese donors was not significantly increased compared with nonobese donors.

Conclusions
Obesity in kidney donors, as in nondonors, is associated with increased risk of developing diabetes and hypertension. The absolute risk of ESKD is small and the risk of death is comparable to that of nonobese donors.
The Necessity of Digital Advertising Literacy for Turkey in the 21st Century
Authors: AYDOĞAN Hediye 
Published: October 2021

The 21st century witnesses that people live in a world intertwined with various kinds of advertising, which
utilize any possible channel to reach its audience to persuade them to think, behave and live in the desired
way, and that the advertising industry progresses further each passing day with the help of opportunities
provided by digital technologies. Therefore, it is vital for the people in this century to avoid falling behind
this progress and develop the necessary skills to defend and empower themselves against any persuasive
messages embedded explicitly or implicitly in digital advertisements. When Turkey is considered, it is seen that the rates of digital ad investments and spending have shown a considerable increase lately, resulting
in a possible increase in the probability of people encountering numerous and different types of digital
advertising during their time spent online, which has also increased dramatically in recent years. From
this point of view, drawing from some preliminary research, this paper attempts to discuss the necessity of
digital advertising literacy in the context of Turkey.
The Pacific OBS Research into Convecting Asthenosphere (ORCA) Experiment
Authors: Eilon Zachary C. , Gaherty James B. , Zhang Lun , Russell Joshua , McPeak Sean , Phillips Joseph , Forsyth Donald W. , Ekström Göran 
Published: October 2021

Abstract
The Pacific ocean-bottom seismometer (OBS) Research into Convecting Asthenosphere (ORCA) experiment deployed two 30-station seismic arrays between 2018 and 2020—a US contribution to the international PacificArray project. The “Young ORCA” array deployed on ∼40 Ma central Pacific seafloor had a ∼68% data recovery rate, whereas the “Old ORCA” array deployed on ∼120 Ma southwest Pacific seafloor had a ∼80% recovery rate. We detail here the seismic data quality, spectral characteristics, and engineering challenges of this experiment. We provide information to assist users of this dataset, including OBS orientations and tables of daily data quality for all channels. Preliminary analysis illustrates the utility of these data for surface- and body-wave seismic imaging.
The Association Between NRMN STAR Grantsmanship Self-Efficacy and Grant Submission
Authors: Jones Harlan P. , Vishwanatha Jamboor K. , Krug Edward L. , Harwood Eileen , Eide Boman Kristin , Unold Thad , Thorpe, Jr. Roland J. 
Published: October 2021

Background: Eliminating the NIH fund­ing gap among underrepresented minori­ties (URMs) remains a high priority for the National Institutes of Health. In 2014, the National Research Mentoring Network1 Steps Toward Academic Research (NRMN STAR) program recruited postdoctoral, early-stage and junior faculty to participate in a 12-month grant writing and professional development program. The expectation of the program was to increase the number of grant submissions and awards to URM re­searchers. Although receiving a grant award is the gold standard of NRMN STAR, instill­ing confidence for postdocs and early-stage faculty to submit an application is a critical first step. Based on our previous study, a sustained increase in trainee self-efficacy score over a 24-month period was observed after completing NRMN STAR.Methods: The current study sought to determine the association between self-efficacy score and grant submissions among two cohorts of trainees. Grantsmanship Self-Efficacy was measured using a 19-item questionnaire previously described by and used in our own work, which was originally adapted from an 88-item Clinical Research Appraisal Inventory.2 A binary variable was created to identify trainees who submit­ted an initial or revised proposal vs those who abandoned their proposal or were still writing. Trainees were assessed prior to and following program completion with subsequent assessments at 6 and 12 months beyond participation.Results: As of June 20, 2019, 12 of the 21 (57%) trainees had submitted a grant proposal (eg, NIH, other federal or non-federal grant). For every point increase in 12-month post assessments, Grantsmanship Self-Efficacy scores across all domains had a 44% higher prevalence of submitting a grant after controlling for race, sex, education level, academic rank, research experience, duration of postdoctoral training, institution type, and NRMN STAR cohort. Conclusions: Our findings demonstrate that NRMN STAR had a positive impact on trainees’ confidence in grant writing and professional development activities, which resulted in higher grant submis­sion rates.Ethn Dis. 2021;31(4):559-566; doi:10.18865/ed.31.4.559
Ansiedad, Depresión y Adaptación Psicosocial en Pacientes Adultos con DM tipo 2
Authors: Osorio Aquino Marina del carmen 
Published: October 2021

Objetivo: Determinar la relación de la ansiedad, la depresión y la adaptación psicosocial de los pacientes con DMT2.
Material y Métodos: El diseño seleccionado fue descriptivo y correlacional. La Población estuvo integrada por 103 adultos de 20 a 60 años de edad con diagnóstico de DMT2 que acudieron al CESSA. Maximiliano Dorantes. Con Muestreo probabilístico.
Resultados: Se observa el 32% tiene ansiedad moderada y tan sólo el 68% presenta ansiedad baja, en cuanto a la depresión el 90.3% y el 9.7% no tiene depresión. Se encontró una negativa significativa entre ansiedad y cuidado de la salud (-3.57**, p=.000) lo cual nos indica entre mayor ansiedad hay mala adaptación. Se obtuvo una negativa positiva (-.642**, p=.000) entre ansiedad y ambiente laboral, es decir entre mayor ansiedad, la adaptación es mala. Se encontró una negación significativa entre depresión y ambiente laboral (.530**, p=.000) lo que indica entre mayor depresión mala adaptación.
Conclusión: Los pacientes al perder la capacidad de afrontamiento caen en depresión y ansiedad puede ser leve, moderada o alta. Esto depende en gran medida del apoyo que reciban de sus familiares. La adaptación psicosocial que vive cada individuo varía de acuerdo al entorno en el que se encuentra, algunos cuentan con el apoyo de sus familiares pero, no cuentan con el recurso económico, otros tienen la facilidad económica pero, no cuentan con el apoyo de sus familiares, se tienen que adaptar a los nuevos cambios de su vida diaria, lo cual no es y no será nada fácil, sino cuentan con ningún tipo de ayuda.
Palabras claves: Ansiedad, Depresión, Adaptación Psicosocial y Adulto mayor
Tendencia de la depresión según licencia médica psiquiátrica en Ñuble, Chile 2008 – 2017
Authors: Alarcon María , Robles Inostroza Ivette Fernanda , Gutiérrez Turner Eduardo , Alarcón Araneda José David 
Published: October 2021

Objetivo: Identificar cambios en la tendencia anual (TA) de las características de las Licencias Médicas por Depresión del Fondo Nacional de Salud en la Región de Ñuble, Chile 2008-2017.
Materiales y Métodos: Estudio descriptivo y de tendencia que incluyó 34.467 de estas licencias médicas registradas en la Comisión de Medicina Preventiva e Invalidez de la Secretaria Ministerial de Salud de la Región de Ñuble, según características en número de licencias, tipo de licencia, tipo de diagnóstico CIE-10, y entidad pagadora de subsidio. Los resultados se presentaron en números absolutos y porcentajes, para el cambio en la TA se construyó un modelo de regresión de Joinpoint, y se utilizó el software Joinpoint Regression Program, Version 4.7.0.0.
Resultados: El número de licencias médicas por depresión aumentaron 152,3% del 2008 al 2017, según Tipo de Licencia 99,7% fue por enfermedad o accidente común, por Tipo de Diagnóstico CIE-10 50,7% fue por episodio depresivo inespecífico (F32.9), 71,6% por pagadora de subsidio cajas de compensación. El modelo Joinpoint no identificó un cambio en la TA en el número de las licencias médicas en los 10 años en estudio, más bien hubo un aumento constante estimado en 166 licencias (p=0,122) por cada año.
Conclusiones: Las licencias médicas FONASA por depresión van en aumento constante en la Región de Ñuble, se requiere privilegiar las estrategias de promoción y prevención en el nuevo plan de salud mental 2017-2025, y que estos esfuerzos se reflejen en el control de esta patología y en la disminución de este tipo de licencias médicas.
Estudio preliminar de un enjuague bucal de solución salina como muestra diagnóstica para SARS-CoV-2
Authors: Suarez Mendez Samuel , García-Vázquez Carlos García-Vázquez , Del Valle-Laveaga David , Juárez-Rojop Isela Esther , Ruiz-Quiñones Jesús Arturo 
Published: October 2021

Objective: To assess the feasibility of a saline mouth rinse (SMR) as a diagnostic tool for the detection of SARS-CoV-2 in outpatients.

Method: This was a prospective study carried out at the Hospital Regional de Alta Especialidad “Dr. Juan Graham Casasús”, 34 SMR/NPS (saline mouth rinse/nasopharyngeal swab) randomized paired samples were selected and collected in the outpatient clinic. The samples were analyzed by real-time reverse transcription polymerase chain reaction (RT-PCR) and the sensitivity and concordance between SMRs and NPS samples were calculated.

Results: Out of the 34 SMR/NPS paired samples, 11 samples were positive for SARS-CoV-2. Eight discrepancies were observed between the two types of samples (7 individuals were positive by NPS and 1 for SMR). We found 3 positive concordant results in the SMRs/NPD paired samples, the mean CT for each gene (RdRp, N, E) did not show a significant difference between the samples. The concordance observed between SMR and NPS was acceptable (kappa coefficient 0.31) with a sensitivity of 0.30 and 0.75 for the SMR and NPS samples, respectively.

Conclusions: The SMR sensitivity is not comparable with NPS sensitivity for SARS-CoV-2 detection, but our data suggest SMR as a non-invasive tool that allows self-collection, and it does not require health trained personnel for its collection. Also, this sample could be an alternative to the lack of swabs and/or viral transportation media. Additionally, SMR may be of benefit in remote and vulnerable populations, and/or to facilitate the screening of SARS CoV-2 in a large number of individuals.
Student satisfaction with the Service-Learning methodology: an added value in the training of the nursing degree
Authors: García Garcés Laura , Ruiz-Zaldibar Cayetana , Gerónimo Llopis Ángel , Vicario Merino Ángel , Lluesma Vidal Marta 
Published: October 2021

Objective: To evaluate the effect on the satisfaction of nursing students and the participants of Service-Learning methodology in the development of Health Education workshops. Method: Service-Learning project was designed in four stages: 1) students training in knowledge about Community Nursing and Health Education; 2) development of healthy workshops for its implementation in associations; 3) implementation of the workshops; 4) reflection on Service-Learning impact. An ad hoc questionnaire was developed to assess students’ satisfaction. It was also evaluated the workshops’ participant’s satisfaction. Results: students reported having a very high level of satisfaction by increasing their scores after improving Service-Learning methodology in the subject. In addition, participants who received health promotion workshops developed by nursing students reported a positive impact on their health. Conclusion: development of Service-Learning methodology associated with health education implies high level of satisfaction in nursing students and a social impact for the community.
Thirty-Day Mortality for Proximal Femoral Fractures Treated at a U.K. Elective Center with a Site-Streaming Policy During the COVID-19 Pandemic
Authors: Beaven A. , Piper D. , Plant C. , Sharma A. , Agrawal Y. , Cooper G. 
Published: October 2021

Background:
COVID-19 led to the reconfiguration of U.K. orthopaedic trauma services because surgical capacity was threatened in acute centers. We report the 30-day mortality of proximal femoral fractures in older adults treated at an elective orthopaedic center.

Methods:
Patients >60 years old who presented with a proximal femoral fracture to any of 4 sites in the regional trauma network were transferred to our elective center for emergency surgery. Care was modeled according to the National Institute for Health and Care Excellence guidelines, and efforts were made to treat all patients within 36 hours. Data were collected prospectively, and mortality outcomes were recorded.

Results:
Of the 192 patients who presented to the elective orthopaedic center, 167 were treated there. The median age of the latter patients was 88 years (interquartile range, 83 to 79 years). The median Charlson Comorbidity Index was 4 (interquartile range, 4 to 6). The median time from emergency department admission to surgical treatment was 24.5 hours (interquartile range, 18.8 to 34.7 hours). The 30-day rate of mortality was 10.2%. A total of 29 (17.4%) tested positive for COVID-19 during their admission, of whom 10 died, for a case-fatality rate of 34.5%. There were no significant differences in age (p = 0.33) or Charlson Comorbidity Index (p = 0.13) between patients who tested positive and those who did not. There was no significant difference in age between those who tested positive and died and those who tested positive and did not die (p = 0.13), but there was a significant difference in Charlson Comorbidity Index between those subgroups (p = 0.03).

Conclusions:
During a pandemic, an elective orthopaedic center can be reconfigured to a surgical center for older patients with proximal femoral fractures with acceptable health-care quality outcomes.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
A Sequential Approach to the Management of Posterior Glenoid Defects in RSA
Authors: Imai Shinji 
Published: October 2021

Background:
Large posterior glenoid defects pose problems in reverse shoulder arthroplasty (RSA). We have adopted a sequential approach to the management of posterior glenoid defects using asymmetrical reaming, the placement of a ring graft around the central peg (bony-increased offset, or BIO), or structural bone-grafting, depending on the amount of glenoid retroversion. Furthermore, we have devised multiple bioresorbable pinning (MBP)-assisted bone-grafting, in which as many bioresorbable pins as required are inserted, from whichever aspects of the graft necessary, to achieve initial stability.

Methods:
We reviewed 52 shoulders with posterior glenoid defects undergoing RSA between 2014 and 2019 (mean follow-up, 4.8 years; range, 2 to 6 years). Twenty (38.5%) of the shoulders had glenoid retroversion of <15° and were treated by asymmetrical reaming (Group A), 19 (36.5%) of the shoulders had retroversion of ≥15° to <30° and were treated with asymmetrical reaming combined with angulated ring graft around the central peg (Group B), and 13 (25.0%) of the shoulders had retroversion of ≥30° and were treated with MBP-assisted bone-grafting (Group C).

Results:
Mean version correction was 10.6° ± 4.3° in Group A, 20.7° ± 8.8° in Group B, and 33.8° ± 9.6° in Group C. The mean postoperative active anterior elevation was 138.3° ± 12.3°, 128.3° ± 12.3°, and 126.5° ± 15.3° in the 3 groups, respectively. The mean postoperative Constant score was 66.8 ± 14.6, 62.2 ± 13.5, and 61.7 ± 16.7, respectively. The mean preoperative active anterior elevation was significantly higher in Group A than in Group C (p = 0.037). The full or partial graft-incorporation rate (≥25% of original size) was 89.5% in Group B and 100% in Group C. One glenoid fracture and 1 case of transient brachial plexus palsy occurred in Group B (10.5%), and 1 acromion fracture and 2 cases of transient brachial plexus palsy occurred in Group C (23.1%).

Conclusions:
The results of the present sequential approach to management of posterior glenoid defects by the 3 modalities were acceptable. The present MBP-assisted bone-grafting procedure is an effective treatment for cases of shoulder arthropathy with severe posterior glenoid defects. Angulated ring grafting around the central peg may yield equally acceptable results, although its graft-incorporation rate requires further follow-up.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Primary Bankart Repair Versus Arthroscopic Anatomic Glenoid Reconstruction in Patients with Subcritical Bone Loss
Authors: Ali Zakariya S. , Thavorn Kednapa , Murphy Ryland , Sparavalo Sara , Wong Ivan 
Published: October 2021

Background:
Anterior shoulder instability and its treatment is a quickly evolving field of interest in orthopaedics, both for patients and for health-care systems. In this study, we aimed to evaluate the cost-effectiveness of arthroscopic anatomic glenoid reconstruction (AAGR) compared with Bankart repair in the treatment of anterior shoulder instability in patients with subcritical glenoid bone loss.

Methods:
A cost-utility analysis was performed from the perspective of Canada’s publicly funded health-care system. A decision-tree model was created to simulate the progression of patients undergoing either a primary Bankart repair or AAGR. Recently published data were used to determine the recurrence rate and level of glenoid bone loss for the AAGR procedure; the recurrence rate was 1.4% in a cohort with a mean glenoid bone loss of 25.3%. A literature review on the primary Bankart procedure in patients with at least subcritical levels of glenoid bone loss yielded a recurrence rate of 22.9% in patients with a mean glenoid bone loss of 17.5%. AAGR served as the revision surgery for both primary procedures. Health utility scores for anterior shoulder instability were obtained from published literature. Total procedure costs, including costs of operating-room consumables, anesthesia, diagnostic imaging, and rehabilitation, were sourced from a hospital database. A probabilistic sensitivity analysis using 5,000 Monte Carlo simulations was performed, and results were used to create a cost-effectiveness acceptability curve.

Results:
The AAGR procedure was less costly and led to an improvement in quality-adjusted life years (QALYs) when compared with the arthroscopic Bankart repair in the treatment of patients with anterior shoulder instability with subcritical glenoid bone loss (AAGR, cost = $16,682.77 [Canadian dollars] and QALYs = 5.76; Bankart, cost = $16,720.29 and QALYs = 5.46), suggesting that the AAGR is dominant, i.e., lower costs with higher QALYs. Applying a commonly used willingness-to-pay threshold of $50,000 per QALY gained, the probability that the primary AAGR was more cost-effective was 85.8%.

Conclusions:
This study showed that, from the perspective of a publicly funded health-care system, AAGR was the economical treatment option when compared with Bankart repair in anterior shoulder instability with subcritical glenoid bone loss.

Level of Evidence:
Economic and Decision Analysis Level III. See Instructions for Authors for a complete description of levels of evidence.
Vertical Leakage Occurred after an Earthquake: Suggestions for Utilizing the Mixed Flow Model
Authors: Yang Qiuye , Zhang Yan , Fu Li-Yun , Ma Yuchuan , Hu Junhua 
Published: October 2021

Abstract
Permeability is an important parameter of shallow crust that affects underground water migration. It is important to calculate the permeability changes caused by earthquakes for underground engineering safety and pollutant dispersion. The response analysis of groundwater in wells, to Earth tides, has been widely used to calculate permeability. However, the calculation results and the judgment of leakage are controversial. In this study, the water level response of both the M2 and O1 tidal waves in the Zuojiazhuang well was analyzed. An optimization fitting, using the mixed flow model, was performed to calculate the hydraulic parameters of aquifers and aquitards. After the Wenchuan earthquake, the horizontal transmissivity of aquifers increased temporarily and then slowly recovered. However, after the Tohoku earthquake, the horizontal transmissivity increased permanently by one order of magnitude. The vertical hydraulic conductivity increased permanently by three orders of magnitude, meaning that vertical leakage occurred. As both the M2 and the O1 waves are used as constraints for the calculation with the mixed flow model, the results of this study are more precise than those of previous ones. This article also gives some suggestions for utilizing the mixed flow model.