bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions and experiences of a manual therapy trial: a qualitative study of people with moderate to severe COPD
Authors: Baxter Danielle A. , Shergis Johannah L. , Hill Catherine J. , Worsnop Christopher , Coyle Meaghan E. 
Published: July 2021

Abstract
Background
Chronic obstructive pulmonary disease (COPD) presents with physical, emotional and social difficulties that affect quality of life. Multimodal management includes both pharmacological and non-pharmacological strategies, and pulmonary rehabilitation (PR) plays an important role. Recent research has suggested that manual therapies may improve perceptions of dyspnea for people with COPD.

Methods
Focus group interviews were conducted as part of a mixed methods study to assess the feasibility of implementing a manual therapy technique—muscle energy technique (MET)—as an adjunct to PR for people with moderate to severe COPD. Focus group interviews were conducted to examine trial participants views of the intervention and the trial design. A thematic analysis was undertaken to explore the data.

Results
Twelve participants with moderate to severe COPD participated in three focus groups. Participants were motivated to participate in the trial to be proactive about their health. They perceived MET to be a gentle, comfortable form of stretching that allowed them to ‘breathe easier’ and prepared them for PR. A small number of participants reported mild muscular discomfort during MET, but this was short-lasting and was not bothersome. Participants enjoyed the one-on-one contact with researchers and learned more about their breathing while performing spirometric testing. Most participants wanted longer and more frequent MET sessions, and some requested ‘homework’ stretching exercises.

Conclusions
The findings of this study show that a manual therapy intervention was received well by participants in a clinical trial setting. A small number of participants reported mild musculoskeletal discomfort in relation to the MET treatment. Participant preferences for additional and longer treatment sessions should be carefully considered against available resources in future clinical trials.

Trial registration
ANZCTR, ACTRN12618000801213. Registered 11 May 2018 - Retrospectively registered. http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374643&isReview=true
Reproducibility of left ventricular blood flow kinetic energy measured by four-dimensional flow CMR
Authors: Grafton-Clarke Ciaran , Crandon Saul , Westenberg Jos J. M. , Swoboda Peter P. , Greenwood John P. , van der Geest Rob J. , Swift Andrew J. , Vassiliou Vassilios S. , Plein Sven , Garg Pankaj 
Published: July 2021

Abstract
Objectives
Four-dimensional flow CMR allows for a comprehensive assessment of the blood flow kinetic energy of the ventricles of the heart. In comparison to standard two-dimensional image acquisition, 4D flow CMR is felt to offer superior reproducibility, which is important when repeated examinations may be required. The objective was to evaluate the inter-observer and intra-observer reproducibility of blood flow kinetic energy assessment using 4D flow of the left ventricle in 20 healthy volunteers across two centres in the United Kingdom and the Netherlands.

Data description
This dataset contains 4D flow CMR blood flow kinetic energy data for 20 healthy volunteers with no known cardiovascular disease. Presented is kinetic energy data for the entire cardiac cycle (global), the systolic and diastolic components, in addition to blood flow kinetic energy for both early and late diastolic filling. This data is available for reuse and would be valuable in supporting other research, such as allowing for larger sample sizes with more statistical power for further analysis of these variables.
Value-based radiology: what is the ESR doing, and what should we do in the future?
Authors:   European Society of Radiology (ESR), Brady Adrian P. , Visser Jacob , Frija Guy , Bargalló Núria , Rockall Andrea , Brkljacic Boris , Fuchsjäger Michael , Birch Judy , Becker Minerva , Kröncke Thomas 
Published: July 2021

AbstractValue-based radiology (VBR) is rapidly gaining ground as a means of considering the input of radiology practice into individual and societal healthcare, and represents a welcome move away from older metrics focused on counting studies performed, without consideration of whether these studies contributed positively to patient management or to society as a whole. Intrinsic to the process of considering whether radiology activity confers value is recognising the breadth of involvement of radiology in healthcare delivery; previous ESR and multi-society publications have explored this, and have sought to highlight the many ways in which our specialty contributes to patient welfare. This paper is intended to highlight some current ESR activities which already contribute substantially to value creation and delivery, and to outline a selection of practical steps which could be taken by the ESR in the future to enhance value.Patient summaryValue-based radiology (VBR) is a conceptual means of looking at the benefits conferred on patients and on society as a whole by provision of radiology services, as opposed to older means of counting numbers of radiology studies performed, without consideration of whether or not those studies contributed overall value. VBR will become increasingly important in the future as a means of determining resources. The ESR has been a leader in advancing VBR concepts and educating radiologists about this novel way of looking at what we do. This paper is designed to highlight current ESR activities which contribute value to healthcare, and to consider other ways in which the ESR could potentially support value enhancement in the future.
In vivo evaluation of a recombinant N-acylhomoserine lactonase formulated in a hydrogel using a murine model infected with MDR Pseudomonas aeruginosa clinical isolate, CCASUP2
Authors: Sakr Masarra M. , Elkhatib Walid F. , Aboshanab Khaled M. , Mantawy Eman M. , Yassien Mahmoud A. , Hassouna Nadia A. 
Published: July 2021

AbstractFailure in the treatment of P. aeruginosa, due to its broad spectrum of resistance, has been associated with increased patient mortality. One alternative approach for infection control is quorum quenching which was found to decrease virulence of such pathogen. In this study, the efficiency of a recombinant Ahl-1 lactonase formulated as a hydrogel was investigated to control the infection of multidrug resistant (MDR) P. aeruginosa infected burn using a murine model. The recombinant N-acylhomoserine lactonase (Ahl-1) was formulated as a hydrogel. To test its ability to control the infection of MDR P. aeruginosa, a thermal injury model was used. Survival rate, and systemic spread of the infection were evaluated. Histopathological examination of the animal dorsal skin was also done for monitoring the healing and cellular changes at the site of infection. Survival rate in the treated group was 100% relative to 40% in the control group. A decrease of up to 3 logs of bacterial count in the blood samples of the treated animals relative to the control group and a decrease of up to 4 logs and 2.3 logs of bacteria in lung and liver samples, respectively were observed. Histopathological examination revealed more enhanced healing process in the treated group. Accordingly, by promoting healing of infected MDR P. aeruginosa burn and by reducing systemic spread of the infection as well as decreasing mortality rate, Ahl-1 hydrogel application is a promising strategy that can be used to combat and control P. aeruginosa burn infections.
Yttrium-90 quantitative phantom study using digital photon counting PET
Authors: Labour Joey , Boissard Philippe , Baudier Thomas , Khayi Fouzi , Kryza David , Durebex Pascale Veyrat , Martino Sandrine Parisse-Di , Mognetti Thomas , Sarrut David , Badel Jean-Noël 
Published: July 2021

Abstract
Background
PET imaging of 90Y-microsphere distribution following radioembolisation is challenging due to the count-starved statistics from the low branching ratio of e+/e− pair production during 90Y decay. PET systems using silicon photo-multipliers have shown better 90Y image quality compared to conventional photo-multiplier tubes. The main goal of the present study was to evaluate reconstruction parameters for different phantom configurations and varying listmode acquisition lengths to improve quantitative accuracy in 90Y dosimetry, using digital photon counting PET/CT.

Methods
Quantitative PET and dosimetry accuracy were evaluated using two uniform cylindrical phantoms specific for PET calibration validation. A third body phantom with a 9:1 hot sphere-to-background ratio was scanned at different activity concentrations of 90Y. Reconstructions were performed using OSEM algorithm with varying parameters. Time-of-flight and point-spread function modellings were included in all reconstructions. Absorbed dose calculations were carried out using voxel S-values convolution and were compared to reference Monte Carlo simulations. Dose-volume histograms and root-mean-square deviations were used to evaluate reconstruction parameter sets. Using listmode data, phantom and patient datasets were rebinned into various lengths of time to assess the influence of count statistics on the calculation of absorbed dose. Comparisons between the local energy deposition method and the absorbed dose calculations were performed.

Results
Using a 2-mm full width at half maximum post-reconstruction Gaussian filter, the dosimetric accuracy was found to be similar to that found with no filter applied but also reduced noise. Larger filter sizes should not be used. An acquisition length of more than 10 min/bed reduces image noise but has no significant impact in the quantification of phantom or patient data for the digital photon counting PET. 3 iterations with 10 subsets were found suitable for large spheres whereas 1 iteration with 30 subsets could improve dosimetry for smaller spheres.

Conclusion
The best choice of the combination of iterations and subsets depends on the size of the spheres. However, one should be careful on this choice, depending on the imaging conditions and setup. This study can be useful in this choice for future studies for more accurate 90Y post-dosimetry using a digital photon counting PET/CT.
Predictors of parenting stress in parents of children diagnosed with autism spectrum disorder: a scoping review
Authors: Al-Oran Haytham Mohammad , Khuan Lee 
Published: July 2021

AbstractIntroductionIdentifying the predictors of parenting stress in parents of children with autism spectrum disorder is crucial to provide the best health-care services.Main textThe scoping review was conducted. Search engines (EBSCO, Springer, PubMed, Ovid, Google Scholar, and Science Direct) were used to collate published studies between the years 2009 and 2020. Keywords used were parenting stress, parental stress, predictors of parenting stress, Autism disorder, Autism, and scoping review. Primary screening of the titles and abstracts of 1039 articles was conducted. The secondary screening of 348 articles resulted in 27 articles included in this review. The reviewed articles revealed core symptoms of the disorder, namely, behavior problems, and socio-communication impairments strongly linked with the high level of parenting stress.ConclusionThis scoping review is the initial step toward encouraging future efforts to provide supportive interventions for parents of children with autism spectrum disorder.
Functional enrichment of gut microbiome by early supplementation of Bacillus based probiotic in cage free hens: a field study
Authors: Khan Samiullah , Chousalkar Kapil K. 
Published: July 2021

AbstractBackgroundThe chicken gut microbiota passes through different stages of maturation; therefore, strengthening it with well characterised probiotics increases its resilience required for optimum gut health and wellbeing. However, there is limited information on the interaction ofBacillusbased probiotics with gut microbial community members in cage free laying chickens both in rearing and production phases of life. In the current study, we investigated the changes in the gut microbiome of free range hens in the field afterBacillusbased probiotic supplementation.ResultsOverall, at phylum level, probiotic supplementation increased the populations of Bacteroidetes and Proteobacteria mainly at the expense of Firmicutes. The population of Bacteroidetes significantly increased during the production as compared to the rearing phase, and its higher population in the probiotic-supplemented chickens reflects the positive role ofBacillusbased probiotic in gut health. Core differences in the beta diversity suggest that probiotic supplementation decreased microbial compositionality. The non-significant difference in alpha diversity between the probiotic and control chickens showed that the composition of community structure did not change. NoSalmonellaspp. were isolated from the probiotic supplemented birds. Egg internal quality was significantly higher, while egg production and body weight did not differ. Functional prediction data showed that probiotic supplementation enriched metabolic pathways, such as vitamin B6 metabolism, phenylpropanoid biosynthesis, monobactam biosynthesis, RNA degradation, retinol metabolism, pantothenate and CoA biosynthesis,phosphonate and phosphinate metabolism, AMPK signaling pathway, cationic antimicrobial peptide (CAMP) resistance and tyrosine metabolism.ConclusionsOverall, age was the main factor affecting the composition and diversity of gut microbiota, where probiotic supplementation improved the abundance of many useful candidates in the gut microbial communities. The generated baseline data in the current study highlights the importance of the continuous use ofBacillusbased probiotic for optimum gut health and production.
Low-temperature conversion of Fe-rich sludge to KFeS2 whisker: a new flocculant synthesis from laboratory scale to pilot scale
Authors: Liang Dongxu , Chen Yu , Zhu Suiyi , Gao Yidi , Sun Tong , Ri Kyonghun , Xie Xinfeng 
Published: July 2021

AbstractHerein, a KFeS2 whisker was formed in mass production at a low temperature, with waste cold-rolling sludge as Fe source, which exhibited good performance in the removal of Zn/Ni from real electroplating effluent. At laboratory scale, KFeS2 was generated at 80 °C by the hydrothermal method, and KFeS2 whisker grew radially with the extension of the reaction time. This method was applied at pilot scale, where a similar KFeS2 whisker was also produced with waste cold-rolling sludge as Fe source, and a residual brownish supernatant was observed after the reaction and then completely recycled in the next round for KFeS2 synthesis. After recycling five times, the produced KFeS2 whisker did not change. The drying and storage of KFeS2 have also been verified. Freeze drying and vacuum drying were applicable, whereas air drying was not profitable. Moreover, the efficiency of Zn/Ni removal using undried KFeS2 was similar to that of dried KFeS2. The efficiencies of Zn/Ni removal using KFeS2 were apparently higher those of common reagents for wastewater treatment.
Contrast-enhanced spectral mammography: successful initial clinical institute experience
Authors: Chalabi Nivine Abdel Moneim , AbuElMaati Amal Amin , Elsadawy Momena Essam Ibrahim 
Published: July 2021

Abstract
Background
Contrast-enhanced spectral mammography (CESM) is a relatively newly developed advanced application with modification of digital mammography by the use of a contrast agent, but still has little known efficacy among Egyptian patients. Our aim in this study is to share our initial experience in evaluating symptomatic patients with different ACR breast parenchyma especially in dense breast parenchyma as it is always challenging in diagnosis.

Results
CESM in this study gave a sensitivity of 92% and specificity of 85% in characterization of benign and malignant lesions. For postoperative cases, sensitivity was 85% and specificity was 60%. For chemotherapy cases, sensitivity was 85% and specificity was 76%. Contrast uptake was noted in 68% of masses. Cavitary benign lesions were noted in 22.1% of cases. Multifocal and multicentric carcinomas were detected in 39.7% of pathologically proved malignant masses. Statistical analysis revealed sensitivity, specificity, and accuracy of 82.9%, 76.5%, and 81.0% for conventional mammograms as compared to 92.7%, 82.4%, and 89.7% for CESM respectively.

Conclusion
CESM is a promising technique that can enhance the specificity of conventional mammograms. It is an easy, simple, and rapid contrast-based procedure, especially for characterization of lesions in dense breast parenchyma. It performs proper diagnosis for high-risk patients and follow-up response to different lines of management.
Dietary risk factors and therapy outcomes of swallowing-related problems in laryngopharyngeal reflux: patients’ perspectives
Authors: Mahmoud Nesreen Fathi , Atta Aliaa Abd El-Aziz , Elhamouly Moamena Said , Abdelmonem Ahmed Ali , Bassiouny Samia El-Sayed 
Published: July 2021

Abstract
Background
This was a prospective cohort that included 60 gastro-esophageal reflux disorder patients with suspected laryngopharyngeal reflux-related symptoms (e.g., sore throat, throat clearing, globus sensation, cough, dysphonia, and dysphagia). The diagnosis was confirmed using history taking, clinical laryngoscopic examination, and upper endoscopy guided by the Reflux Symptom Index (RSI). Patients were treated with proton pump inhibitors and prokinetics for 12 weeks. The aim of the current study was to explore the dietary risk factors in laryngopharyngeal reflux patients and to assess the response to therapy on swallowing-related problems by comparing the baseline pre-treatment and post-treatment values of RSI and Dysphagia Handicap index (DHI).

Results
Analysis of data regarding the role of diet as a risk factor for reflux revealed that 33 patients (55%) are eating meat, 56 patients (93.3%) eating fat, 45 patients (75%) eating sweet, 55 patients (91.7%) eating spicy food, 52 patients (96.7%) eating fried food, 34 patients (56.7%) drinking tea, 51 patients (85%) eating big meals, 21 patients (35%) drinking fruit juices, 54 patients (90%) eating sour foods, 51 patients (85%) eating citrus fruits, and 22 patients (36.7%) smokers. There was a statistically significant decrease in Reflux Symptom Index scores and an increase of Dysphagia Handicap Index scores after 12 weeks on proton pump inhibitors and prokinetics.

Conclusion
Different dietary factors were present in LPR patients. A short period of empiric anti-reflux treatment has a significant improving effect on Reflux Symptom Index and Dysphagia Handicap Index scores from baseline to 12 weeks post-treatment. Further research is needed to investigate longer times of treatment for the complete resolution of symptoms.
Issues in conserving ‘orphan heritage’ in Asia: WWII battlefield conservation in Hong Kong and Malaysia
Authors: Wang Yi-Wen , DiMeolo Jesse , Du Gao 
Published: July 2021

AbstractWars and conflict have existed since the beginning of time. Most battlefield conservation work is done for battlefields that lie in the borders of the nations that were involved, thus fostering citizens’ personal ties with the site and their national identities. However, some areas of the world suffer from conservation neglect because of the distance and separation between the battlefield’s location and the country to which it is relevant, thus creating a dislocated appreciation of heritage described by Price (J Confl Archaeol 1:181–196, 2005) as ‘orphan heritage’. This paper questions the extent to which post-colonial nations are willing to protect and conserve World War II battlefields on their soil. It examines two battlefields in Asia—the Gin Drinkers’ Line in Hong Kong, China, and the Green Ridge battlefield in Kampar, Malaysia—that have been the subject of campaigns to recognise their transnational heritage value. Both battles involved multinational Allied forces led by the British against Japanese troops. A combination of political and economic factors has influenced how the two battlefields are understood and appreciated by citizens and local governments in the host nations. The paper delineates how these two Asian battlegrounds, which are relatively unknown to the general public, have been brought to the public’s attention and by whom as well as how the local governments have handled the demand to safeguard the battlefields. We argue that the global nature of WWII makes its commemoration geographically challenging and politically contentious. The WWII battlefields in Asia attest to the historical authenticity of past conflicts and thus should be conserved as neutrally as possible. The successful protection of battlefields in Malaysia and Hong Kong thus far can be largely attributed to grassroots initiatives, pressure from stakeholder countries, such as the UK, and academic research whereby the significance of the battleground is made known to people in Hong Kong and Malaysia. With public support, responsible government leadership and a shared understanding of their importance as transnational heritage, WWII battlefields can help calm bitter resentment and promote reconciliation.