bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of thiamethoxam seed treatment in peanut
Authors: Monfort Scott , Culbreath Albert , Abney Mark , Brandenburg Rick , Royals Brian , Jordan David , Herbert Ames , Taylor Sally , Malone Sean 
Published: September 2021

AbstractTobacco thrips (Frankliniella fusca) and tomato spotted wilt (TSW) orthotospovirus (family Tospoviridae, genus Orthotospovirus) can reduce peanut (Arachis hypogaea L.) yield. Systemic insecticides are applied in the seed furrow at planting and to peanut foliage to reduce injury from tobacco thrips and decrease incidence of TSW. Research was conducted in Georgia, North Carolina, South Carolina, and Virginia in 2013 and 2014 to compare the effect of the following treatments on tobacco thrips feeding injury and expression of TSW in peanut: thiamethoxam seed treatment, thiamethoxam seed treatment followed by acephate 3 weeks after planting, phorate applied in the seed furrow at planting, and a nontreated check. Tobacco thrips feeding injury and TSW incidence were significantly higher in thiamethoxam and thiamethoxam followed by acephate‐treated peanut than peanut treated with phorate. Thiamethoxan seed treatment followed by acephate resulted in significantly lower tobacco thrips feeding injury compared to thiamethoxam seed treatment alone. Yield of Virginia market type cultivars was greater when thiamethoxam was followed by acephate applied to peanut foliage or when phorate was applied compared with nontreated peanut or the seed treatment alone. Runner market type cultivars yielded higher when phorate was applied compared with nontreated peanut while peanut treated with thiamethoxam with or with acephate yielded similar to both of these treatments.
Appearance of microtubules at the cytokinesis to interphase transition in Arabidopsis thaliana
Authors: Lucas Jessica R. 
Published: September 2021

AbstractMicrotubule arrays drastically reorganize during the cell cycle to facilitate specific events. Many cells contain a centrosome that dictates the assembly and organization of microtubule arrays. However, plant cells and many others do not contain centrosomes or discrete microtubule organizing centers. In plants, microtubules nucleate and polymerize from gamma‐tubulin‐containing complexes in the interphase cell cortex. During plant cell division, microtubules nucleate near nuclei to form the mitotic spindle and plant‐specific phragmoplast required for cytokinesis. Therefore, during the plant cell cycle, microtubule nucleation shifts from cell cortex to the perinuclear region. While it is unclear how this shift occurs, previous studies observed microtubules that appeared to extend from nuclei into the cortex as cells transitioned into interphase in small cells. These data led to the hypothesis that microtubule nucleation complexes move from the nuclear surface to the cortex at the transition from cytokinesis into interphase. Here we document GFP labeled microtubules in living plant cells during the transition from cytokinesis to interphase. We observed apparent groups of microtubules spanning between the nucleus and cell cortex in large, vacuolated epidermal leaf cells. We also observed microtubules in the cell cortex that appeared separate from perinuclear‐associated microtubules. While these cortical microtubules were not always seen, when present they were apparent before cytokinesis was complete and/or before nuclear‐associated microtubules were obvious. These data add to and deepen the knowledge of microtubule reorganization at this cell cycle transition.
Tracking Reaction Pathways by a Modular Flow Reactor Coupled to Electrospray Ionization Mass Spectrometry
Authors: Tripodi Guilherme L. , Derks Max T. G. M. , Rutjes Floris P. J. T. , Roithová Jana 
Published: September 2021

AbstractInvited for this month's cover is the group of Jana Roithová at the Radboud University (The Netherlands). The cover picture shows a mini‐plant for automated monitoring of chemical reactions. Flow chemistry enables screening of chemical reactions under well‐defined conditions that can systematically vary. Mass spectrometry couples it with the detection of low abundant reaction intermediates. Therefore, this platform allows tracking reaction pathways, monitoring reaction kinetics of intermediates and is set for a discovery of novel chemical transformations in future. Read the full text of their Full Paper at 10.1002/cmtd.202100046.
Monitoring Aqueous Phase Reactions by Operando ATR‐IR Spectroscopy at High Temperature and Pressure: A Biomass Conversion Showcase
Authors: Khalili Khaled N. M. , de Peinder Peter , Bruijnincx Pieter C. A. , Weckhuysen Bert M. 
Published: September 2021

AbstractInvited for this month's cover is the group of Bert M. Weckhuysen at the Utrecht University (The Netherlands). The cover picture shows an attenuated Total Reflection Infrared spectroscopy (ATR‐IR) probe monitoring a chemical reaction in the liquid phase, particularly water, at demanding conditions. The light penetrates few microns deep in proximity of the ATR‐IR probe and thus any IR‐active entity in that range is probed. This research systematically addresses the challenges associated with acquiring operando ATR‐IR spectra for liquid/aqueous phase reactions, which is essential for better understanding of chemical reactions in the liquid phase. Read the full text of their Full Paper at 10.1002/cmtd.202100041.
Nanocellulose: Production and Processing for Biomedical Applications
Authors: Brenes Ricardo Gonzalo Ramírez , Grieco Maria Angela Bernardes , Bojorge Ninoska , Pereira Nei 
Published: September 2021

AbstractNanocellulose (NC) is a unique and promising natural material derived from native cellulose. It has attracted much attention for its versatility in construction composites, which have improved chemical and mechanical properties. This review covers the type of biomass used and NC production methods, emphasizing biotechnological routes, which promote their biological properties (biocompatibility, biodegradability and low toxicity), fundamental for medical applications. NC has many hydroxyl groups on its surface, enabling its structure to be modifiable, adaptable and viable for various fields. Furthermore, NC‐based biosensors are suitable for food quality control, monitoring environmental analytes, and particularly in health diagnostics, such as COVID19 detection. The developed analytical devices were described in a table, including information about the sensor molecule, reading system, analyte, range, detection limit, sensitivity and analytical performance.
Efficient Photo‐Thermo‐Electric Conversion Using Polyoxovanadate in Ionic Liquid for Low‐Grade Heat Utilization
Authors: Wang Yan , Liu Congyan , Wang Yang , Zhu Chaofeng , Chen Xihai , Liu Bo 
Published: September 2021

AbstractA large fraction of energy, including solar energy, is dissipated into ambient atmosphere as low‐grade waste heat. Efficient utilization of such energy is critical to address the current energy crisis and global warming issue. Herein, the efficient near‐IR (NIR)‐photothermal, thermoelectric, and thus photo‐thermo‐electric conversion of polyoxovanadate compound {[Ni(1,10‐phenanthroline)3][V14O34Cl]Cl, NiV14} in ionic liquid was achieved. The solution displayed a NIR‐photothermal efficiency of 16.04 and 23.43 % at 808 and 1064 nm, respectively. Taking advantage of the synergetic thermodiffusive and thermogalvanic effects of various ion species in NiV14 solution, an open circuit voltage of approximately 0.45 V was obtained at ΔT=70 K generated by physical heating or NIR irradiation, indicating a large Seebeck coefficient of 6.38 mV K−1 and an optimized thermal power at 1.2 W m−2. The polyoxovanadate‐ionic liquid system offers a new platform for efficiently utilizing not only low‐grade thermal energy but also solar energy for electricity generation.
IgM and IgA augmented autoantibody signatures improve early‐stage detection of colorectal cancer prior to nodal and distant spread
Authors: Roney Md Saiful Islam , Lanagan Catharine , Sheng Yong Hua , Lawler Karen , Schmidt Christopher , Nguyen Nam‐Trung , Begun Jakob , Kijanka Gregor Stefan 
Published: September 2021

AbstractObjectivesTumor‐associated autoantibodies (AAbs) in individuals with cancer can precede clinical diagnosis by several months to years. The objective of this study was to determine whether the primary immune response in form of IgM and gut mucosa‐associated IgA can aid IgG AAbs in the detection of early‐stage colorectal cancer (CRC).MethodsWe developed a novel protein array comprising 492 antigens seropositive in CRC. The array was used to profile IgG, IgM and IgA antibody signatures in 99 CRC patients and 99 sex‐ and age‐matched non‐cancer controls. A receiver operating curve (ROC), Kaplan–Meier survival analysis and univariate and multivariate Cox regression analyses were conducted.ResultsWe identified a panel of 16 multi‐isotype AAbs with a cumulative sensitivity of 91% and specificity of 74% (AUC 0.90, 95% CI: 0.850–0.940) across all CRC stages. IgM and IgG isotypes were conversely associated with disease stage with IgM contributing significantly to improved stage I and II sensitivity of 96% at 78% specificity (AUC 0.928, 95% CI: 0.884–0.973). A single identified IgA AAb reached an overall sensitivity of 5% at 99% specificity (AUC 0.520, 95% CI: 0.440–0.601) balanced across all CRC stages. Kaplan–Meier analysis revealed that se33‐1 (ZNF638) IgG AAbs were associated with reduced 5‐year overall survival (log‐rank test,P = 0.012), whereas cumulative IgM isotype signatures were associated with improved 5‐year overall survival (log‐rank test,P = 0.024).ConclusionIgM AAbs are associated with early‐stage colorectal cancer. Combining IgG, IgM and IgA AAbs is a novel strategy to improve early diagnosis of cancers.
CircIMMP2L promotes esophageal squamous cell carcinoma malignant progression via CtBP1 nuclear retention dependent epigenetic modification
Authors: Liang Yingkuan , Mao Qixing , Wang Lin , Xia Wenjie , Chen Bing , Wang Hui , Li Rutao , Xu Lin , Jiang Feng , Dong Gaochao 
Published: September 2021

AbstractBackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers. The two major lethal causes of ESCC are diagnosis at an advanced stage and lymph node metastasis (LNM). Circular RNAs (circRNAs) play critical regulatory roles in cancer progression, though, largely through unclear mechanisms. However, the character of circRNAs in the malignant progression of ESCC remains unclear.MethodsThe circRNA microarray was used to explore the circRNAs that were differentially expressed between ESCC and paired adjacent normal tissues. The function of circIMMP2L was validated by gain or loss of function assays. Pull‐down, RNA immunoprecipitation assays were used to demonstrate the biological mechanism of circIMMP2L. Tissue microarray (TMA), specimen, and paired plasma were investigated to evaluate the clinical significance of circIMMP2L.ResultsCircIMMP2L, commonly upregulated in tumor and plasma from advanced‐stage ESCC patients and LNM patients, predicts poorer patient survival. CircIMMP2L was also found to be a significant indicator for LNM, even in the T1 stage of ESCC. CircIMMP2L depletion suppressed the malignant progression of ESCC both in vitro and in vivo. Mechanistically, cytoplasmic circIMMP2L interacted with CtBP1 and facilitated the nuclear retention of CtBP1 in a CtBP2‐independent manner. Moreover, circIMMP2L promoted the interaction of CtBP1 with HDAC1 in the nucleus, which is essential for epigenetic remodeling and transcriptional suppression of E‐cadherin and p21.ConclusionsThese findings demonstrated that circIMMP2L promotes the malignant progression of ESCC mediated by CtBP1 nuclear retention and is a robust biomarker for the diagnosis, prognosis, and LNM in ESCC. Further, the findings extend our knowledge about the mechanism of circRNA regulation of gene transcription through epigenetics.
RNA N6‐methyladenosine modification in the lethal teamwork of cancer stem cells and the tumor immune microenvironment: Current landscape and therapeutic potential
Authors: Zhang Zhihui , Zhang Chaoqi , Luo Yuejun , Zhang Guochao , Wu Peng , Sun Nan , He Jie 
Published: September 2021

AbstractN6‐methyladenosine (m6A), the newest and most prevalent layer of internal epigenetic modification in eukaryotic mRNA, has been demonstrated to play a critical role in cancer biology. Increasing evidence has highlighted that the interaction between cancer stem cells (CSCs) and the tumor immune microenvironment (TIME) is the root cause of tumorigenesis, metastasis, therapy resistance, and recurrence. In recent studies, the m6A modification has been tightly linked to this CSC‐TIME interplay, participating in the regulation of CSCs and TIME remolding. Interestingly, the m6A modification has also been identified as a novel decisive factor in the efficacy of immunotherapies—particularly anti‐PD‐1/PD‐L1 monotherapies—by changing the plasticity of the TIME. Given the functional importance of the m6A modification in the crosstalk between CSCs and the TIME, targeting m6A regulators will open new avenues to overcome therapeutic resistance, especially for immune checkpoint‐based immunotherapy. In the present review, we summarize the current landscape of m6A modifications in CSCs and the TIME, and also prospect the underling role of m6A modifications at the crossroads of CSCs and the TIME for the first time. Additionally, to provide the possibility of modulating m6A modifications as an emerging therapeutic strategy, we also explore the burgeoning inhibitors and technologies targeting m6A regulators. Lastly, considering recent advances in m6A‐seq technologies and cancer drug development, we propose the future directions of m6A modification in clinical applications, which may not only help to improve individualized monitoring and therapy but also provide enhanced and durable responses in patients with insensitive tumors.
A multi‐omics study delineates new molecular features and therapeutic targets for esophageal squamous cell carcinoma
Authors: Jin Xing , Liu Lei , Wu Jia , Jin Xiaoxia , Yu Guanzhen , Jia Lijun , Wang Fengying , Shi Minxin , Lu Haimin , Liu Jibin , Liu Dan , Yang Jing , Li Hua , Ni Yan , Luo Qin , Jia Wei , Wang Wei , Chen Wen‐Lian 
Published: September 2021

AbstractEsophageal squamous cell carcinoma (ESCC) is a major histological subtype of esophageal cancer with inferior prognosis. Here, we conducted comprehensive transcriptomic, proteomic, phosphoproteomic, and metabolomic characterization of human, treatment‐naive ESCC and paired normal adjacent tissues (cohort 1, n = 24) in an effort to identify new molecular vulnerabilities for ESCC and potential therapeutic targets. Integrative analysis revealed a small group of genes that were related to the active posttranscriptional and posttranslational regulation of ESCC. By using proteomic, phosphoproteomic, and metabolomic data, networks of ESCC‐related signaling and metabolic pathways that were closely linked to cancer etiology were unraveled. Notably, integrative analysis of proteomic and phosphoproteomic data pinpointed that certain pathways involved in RNA transcription, processing, and metabolism were stimulated in ESCC. Importantly, proteins with close linkage to ESCC prognosis were identified. By enrolling an ESCC patient cohort 2 (n = 41), three top‐ranked prognostic proteins X‐prolyl aminopeptidase 3 (XPNPEP3), bromodomain PHD finger transcription factor (BPTF), and fibrillarin (FBL) were verified to have increased expression in ESCC. Among these prognostic proteins, only FBL, a well‐known nucleolar methyltransferase, was essential for ESCC cell growth in vitro and in vivo. Furthermore, a validation study using an ESCC patient cohort 3 (n = 100) demonstrated that high FBL expression predicted unfavorable patient survival. Finally, common cancer/testis antigens and established cancer drivers and kinases, all of which could direct therapeutic decisions, were characterized. Collectively, our multi‐omics analyses delineated new molecular features associated with ESCC pathobiology involving epigenetic, posttranscriptional, posttranslational, and metabolic characteristics, and unveiled new molecular vulnerabilities with therapeutic potential for ESCC.
Inhibition of tumor‐associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti‐PD‐1 therapy
Authors: Belgiovine Cristina , Frapolli Roberta , Liguori Manuela , Digifico Elisabeth , Colombo Federico Simone , Meroni Marina , Allavena Paola , D'Incalci Maurizio 
Published: September 2021

AbstractA considerable proportion of cancer patients are resistant or only partially responsive to immune checkpoint blockade immunotherapy. Tumor‐Associated Macrophages (TAMs) infiltrating the tumor stroma suppress the adaptive immune responses and, hence, promote tumor immune evasion. Depletion of TAMs or modulation of their protumoral functions is actively pursued, with the purpose of relieving this state of immunesuppression. We previously reported that trabectedin, a registered antitumor compound, selectively reduces monocytes and TAMs in treated tumors. However, its putative effects on the adaptive immunity are still unclear. In this study, we investigated whether treatment of tumor‐bearing mice with trabectedin modulates the presence and functional activity of T‐lymphocytes.In treated tumors, there was a significant upregulation of T cell‐associated genes, including CD3, CD8, perforin, granzyme B, and IFN‐responsive genes (MX1, CXCL10, and PD‐1), indicating that T lymphocytes were activated after treatment. Notably, the mRNA levels of the Pdcd1 gene, coding for PD‐1, were strongly increased. Using a fibrosarcoma model poorly responsive to PD‐1‐immunotherapy, treatment with trabectedin prior to anti‐PD‐1 resulted in improved antitumor efficacy. In conclusion, pretreatment with trabectedin enhances the therapeutic response to checkpoint inhibitor‐based immunotherapy. These findings provide a good rational for the combination of trabectedin with immunotherapy regimens.
Efficient Synthesis of Cu(II)‐N‐Heterocyclic Carbene Complexes in Water and Their Activity Towards Aerobic Alcohol Oxidation
Authors: Ahmad Bhat Irshad , Avinash Iruthayaraj , Kumar Sachan Sharad , Singh Sadhana , Anantharaman Ganapathi 
Published: September 2021

AbstractThe majority of the copper N‐heterocyclic carbene (NHC) complexes contain Cu in a +1 oxidation state. The Cu(II)‐NHC complexes reported so far usually require strict inert atmosphere conditions. In this work, we report a very facile and quantitative preparation of a series of new Cu(II)‐NHC complexes (2 a–c) starting from the inexpensive and readily available Cu(II) salts like Cu(OAc)2 and CuCl2 ⋅ 2H2O with imidazolium salts (1 a–c), wherein 2 b and 2 c were exclusively synthesized in water under aerobic condition. It should be emphasized that this is the first example where Cu(II)‐NHC complexes have been prepared in the aqueous medium. All the complexes have manifested with a heterobidentate C, O chelate type of coordination to Cu(II) centers forming trans‐[Cu(IRpyO)2] (where R=Me, Mes, Dipp) type of complexes where 2 b forms a perfect square planar Cu(II)‐NHC complex. Complexes 2 a–c were evaluated as catalysts for the aerobic oxidation of alcohols.
A new hedging hypothesis regarding prediction interval formation in stock price forecasting
Authors: Zhu Dan , Wang Qingwei , Goddard John 
Published: September 2021

AbstractWe propose and test a simple hedging hypothesis for prediction interval formation in stock price forecasting. In the presence of uncertainty, forecasters hedge their forecasts by adjusting the bounds of the prediction interval in a way that reflects their forecast of the average forecast of others. This hypothesis suggests a positive relationship between the belief wedge, defined as the difference between the subject's forecast of the average forecast of others and the subject's own point forecast, and the asymmetry of the prediction interval. Empirical support for the hedging hypothesis is drawn from two in‐class surveys, an experiment, and a large survey of professional analysts' forecasts of future stock prices.
Pilot feasibility study of cognitive training exercises for Egyptian adults: Proof of concept
Authors: Tawfik Heba M. , Tsatali Marianna , Hassanin Hany I. 
Published: September 2021

AbstractObjectivesCognitive training exercises (CTE) are promising and effective interventions to enhance cognitive reserve and slowdown cognitive deterioration in people with subjective memory impairment (SCI) and mild cognitive impairment (MCI). In this pilot study, we aimed to assess the feasibility of CTE among Egyptian adults.MethodsEighteen participants above 40 years old were recruited. They underwent baseline neuropsychological assessment and functional assessment. However, after receiving a 6 weeks' cognitive training, eight participants (seven with MCI and one was cognitively intact) dropped out from the study. Finally, 10 participants (8 participants with MCI, 1 with SCI and 1 was cognitively intact) completed 12 weeks of CTE and undergone the post‐assessment afterward. CTE included visual, verbal, memory, executive function, visuospatial, attention, and psychokinetic exercises through onsite and home‐based sessions.ResultsFor the 10 participants who completed 12 weeks of CTE, the Wilcoxon signed‐rank test showed a statistically significant change in the scores of mini‐mental state examination (Z = −2.546, p = 0.011), semantic fluency test (Z = −2.913, p = 0.004), subjective memory complaint questionnaire (Z = −2.913, p = 0.004), Consortium to Establish a Registry for Alzheimer's Disease Word List (first trial: Z = −2.641, p = 0.008; Word list recall: Z = −2.825, p = 0.005), construction abilities (immediate: Z = −2.121, p = 0.034; delayed recall: Z = −2.414, p = 0.016), and Digit span test (forward: Z = −2.724, p = 0.006; backward: Z = −2.724, p = 0.006).ConclusionsThe results of this study suggested that CTE are feasible among Egyptian adults, especially those with MCI, and potentially effective in enhancing global cognition and after 12 weeks of training. Future research should shed light on the efficacy of longitudinal CTE implementation in Arab adults' populations.
Identification of enhancer RNAs for the prognosis of head and neck squamous cell carcinoma
Authors: Feng Guanying , Wang Tianxiao , Xue Feifei , Qi Yibo , Wang Ruixia , Yuan Hua 
Published: September 2021

AbstractBackgroundEnhancer RNAs (eRNAs) play an important role in carcinogenesis. The landscape of eRNAs in head and neck squamous cell carcinoma (HNSCC) remains largely unknown.MethodsThe eRNA expression matrix was obtained from the enhancer RNA in the cancer database. Functional enrichment analyses were performed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG). Prognostic eRNAs were identified using Cox regression analysis, and a prognostic prediction model was constructed based on coefficients.ResultsKEGG analysis showed that eRNA‐related transcription factors were mainly enriched in herpes simplex virus 1 (HSV1) infection. The zinc finger (ZNF) family may play an essential role in HNSCC. ENSR00000188847, ENSR00000250663, ENSR00000313345, ENSR00000317887, and ENSR00000336429 were identified. The prediction model was robust.ConclusionsWe constructed a robust 5‐eRNA prognostic prediction model, and these eRNAs are potential biomarkers for HNSCC prognosis.