bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Silico study of Wheatgrass constituents against Coronavirus COVID-19 Proteins.
Authors: Srus Deshmukh , Pravin Badhe , Kishor Otari , Ashwini Badhe 
Published: December 2021

Abstract
As a result of COVID-19, the coronavirus associated with SARS-CoV-2 has emerged as the most lethal and infectious pandemic in history. Vaccines alone cannot assure us of a healthy future. As a result, drug production must go hand in hand with vaccine production. The purpose of this study is to evaluate the therapeutic potential of certain chemical constituents of Wheatgrass (Triticum aestivum Linn.,) that may be useful for treatment of COVID19. Seven chemical constituents of Wheatgrass, including Ascobic acid (SWA00A), Rutin (SWA00B), Ferulic acid (SWA00C), quercetin (SWA00D), Luteolin (SWA00E), Apigenin (SWA00F), and Kaempferol (SWA00G), were used for virtual screening. Covid19 viral proteins such as 6lu7-SARS-CoV2 main protease, 6zsl-SARS-CoV-2 helicase, 6w9c-papain-like protease of SARS-CoV-2, and 6m71-RNA-dependent RNA polymerase were selected for study. Drugs used in the treatment of COVID-19 namely Remdesivir, Darunavir, Ralimetinib, Berzosertib, Alpha-interferon, Arabinol, Chloroquine phosphate, Indinavir, Lopinavir, Ritonavir, Plegylated alfa interferon, 2-chloro-2-deoxy-D-glucose are taken as standards. Molecular docking was performed using the PyRx Virtual Screening tool. Among all 7 chemical components, Rutin (SWA00B) had the strongest binding affinity. According to the present study, Rutin present in Wheatgrass shows the highest potential to inhibit SARS-CoV-2 proteins. Wheatgrass has promising anti-SARS-CoV-2 properties, but further research is needed to prove their efficacy in vivo.
A Randomized Controlled Trial Enhancing Non-Communicable Diseases Health Literacy of Indian Youth
Authors: Jindal Rahul M. 
Published: December 2021

Abstract
Background

There is a theory-praxis gap related to health literacy interventions focused on non-communicable diseases (NCD) among young people. We designed a NCD curriculum and investigated its’ effect on health literacy in non-medical, non-nursing college students in India. We deliberately selected non-medical and non-nursing college students as we hypothesized they would have minimal baseline knowledge of NCDs.
Methods

We initially carried out a pilot study in 85 students in a four-day long workshop (12 teaching hours) using empirically developed health literacy instrument. We administered the curriculum to 120 randomly selected students in 4 colleges, while 50 students were controls. The curriculum was given over 4 days for a total of 32 hours. Each lecture comprised of didactic lecture followed by discussion and skills testing of measuring BP and blood sugar. Health literacy was measured using a specifically designed tool at baseline and endline. Difference in health literacy scores between the two time-points was analyzed using the t-test. Multiple linear and Poisson regression models were used for covariates.
Results

Study groups were comparable at baseline. The intervention group showed 20.6% higher health literacy score at endline versus control group (p<0.001). Participants scoring 40% or above on the health literacy measure in both groups were comparable at baseline. However, the proportion of participants scoring 40% or above was higher in the intervention group versus control group at endline (p<0.001).
Conclusions

We provide empirical data to support incorporation of NCDs as a credit course in college curricula in low and middle income countries. This is the first study in the Indian context that addressed NCD-related health literacy in a randomized trial.
Peacocks and the Zeta distributions
Authors: Imad El ghazi 
Published: December 2021

Abstract
We prove in this short paper that the stochastic process defined by: $$Y_{t} := \frac{X_{t+1}}{\mathbb{E}\left[ X_{t+1}\right]},\; t\geq a > 1,$$ is an increasing process for the convex order,where Χt a random variable taking values in N with probability P(Χt = n) = n-t/(𝛇(t)) and 𝛇(t) = +∞∑k=1(1/kt), ∀t > 1.
Achieving Quality and Effectiveness in Dementia Using Crisis Teams (AQUEDUCT): A Study Protocol for a Randomised Controlled Trial of a Resource Kit.
Authors: Coleston-Shields Donna Maria , Challis David , Worden Angela , Broome Emma , Dening Tom , Guo Boliang , Hoe Juanita , Lloyd-Evans Brynmor , Moniz-Cook Esme , Morris Steve , Poland Fiona , Prothero David , Orrell Martin 
Published: December 2021

Abstract
BACKGROUNDImproving care at home for people with dementia is a core policy goal in the dementia strategies of many European countries. A challenge to effective home support is the occurrence of crises in the care of people with dementia which arise from changes in their health and social circumstances. Improving the management of these crises may prevent hospital admissions and facilitate better and longer care at home. This trial is part of a National Institute for Health Research funded programme, AQUEDUCT, which aims to improve the quality and effectiveness of teams working to manage crises in dementia.METHODS/DESIGNIt is a pragmatic randomised controlled trial of an online Resource Kit to enhance practice in teams managing crises in dementia care. Thirty teams managing mental health crises in dementia in community settings will be randomised between the Resource Kit intervention and treatment as usual. The primary outcome measure is psychiatric admissions to hospital for people with dementia in the teams’ catchment area recorded six months after randomisation. Other outcomes include: quality of life measures for people with dementia and their carers; practitioner impact measures; acute hospital admissions; and costs. To enhance understanding of the resource kit intervention, qualitative work will explore staff, patient and carers’ experience.DISCUSSIONThe Resource Kit intervention reflects current policy to enable home-based care for people with dementia by addressing the management of crises which threaten the viability of care at home. It is based upon a model of best practice for managing crises in dementia designed to enhance the quality of care, developed in partnership with people with dementia, carers and practitioners. If the Resource Kit is shown to be clinically and cost effective in this study, this will enhance the probability of its incorporation into mainstream practice. TRIAL REGISTRATION: ISRCTN 42855694; Registered on 04/03/2021; Protocol number: 127686/2020v9; Research Ethics Committee, 09/03/2021, Ref 21/WM/0004; IRAS ID: 289982https://doi.org/10.1186/ISRCTN42855694
COVID-19 test positivity rate dynamics in West Sumatra, Indonesia: a retrospective study
Authors: Putra Syandrez Prima , Lailani Mutia , Mahata Liganda Endo , Rezvi SM , Putra Andani Eka 
Published: December 2021

Abstract
Background: COVID-19 test positivity rate (TPR) is essential to estimate and control SARS-CoV-2 transmission in a population at a specific time, yet the TPR trends at a provincial level in Indonesia are unclear. This study aimed to determine the COVID-19 TPR dynamics of the Indonesian West Sumatra province in the first year of documented cases.Methods: We conducted a retrospective study using secondary data of the COVID-19 quantitative reverse transcription-polymerase chain reaction (q-RT-PCR) test in West Sumatra Province from April 2020 to March 2021. To examine trends, we estimated TPR(s) on an annual, quarterly, and monthly basis in the province, its regions (cities/ regencies), and districts.Results: From a total of 410,424 individuals taking the COVID-19 q-RT-PCR examination during one year, the provincial TPR was 8.11%. The third quarter (October 2020 – December 2020, 12.18%) and October 2020 (15.62%) had the highest TPR quarterly and monthly, respectively. The TPR of cities was almost certainly twice that of regencies. Annual TPR varied significantly (p<0.001) across regions, districts, and periods.Conclusion: The COVID-19 TPR trends in West Sumatra at the first year of the pandemic were generally higher than the global recommendation. Further study on population density, public mobility, and implementation of health protocol in the province should be valuable to understand TPR dynamics.
Bio quantum path duality metamorphosizes Newtonian rigid inertia into bio-inertia
Authors: Lai Yi Yu 
Published: December 2021

Abstract
Newtonian inertia has initiated science centuries ago and dictates modern society with isolated logic systems. The hidden premise of this system is rigid existence in an isolated environment that defies any internal motion. The equivalent principle from general relativity and the T-symmetry reversible processes from thermodynamics also rely on such a notion. However, bio-inertia originates from the blind spots of this system; surface tension region inversion as the most general interactions is sacrificed for methodological isolation/test purposes and then neglected by science. We define and experiment bio-inertia as “parameter-against-gravity-recovery”, revealing the interaction between Planck regions and surface tension regions issues negentropy, conventional quantum collapse period is then extended to lifespan. This modulation which integrates quantum mechanics, gravitational waves, thermodynamics into surface tension bio quantum path duality needs to break the isolated logic method and takes musical inversion as structural dynamics in bio-systems, generalized as Basic Law of Evolution. An original evolutionary physical string oscillation memory equation is unveiled for the first time.
Transfer Learning Based Surface Roughness Prediction Integrating Tool Wear Under Variable Cutting Parameters
Authors: Wang Yahui , Zheng Lianyu , Wang Yiwei , Zhou Jian , Tao Fei 
Published: December 2021

Abstract
The monitoring of surface quality in machining is of great practical significance for the reliability and life of high-value products such as rocket, spacecraft and aircraft, particularly for their assembly interfaces of these products. Surface roughness is an important metric to evaluate the surface quality. The current research of online surface roughness prediction has the following limitations. The effect of the varying tool wear on the surface roughness is rarely considered in machining. In addition, the deteriorating trend of surface roughness and tool wear is different under variable cutting parameters. Prediction models trained under one set of cutting parameters fail when cutting parameters change. This paper proposes a surface roughness prediction method considering the varying tool wear under variable cutting parameters. A stacked autoencoder and long short-term memory network (SAE-LSTM) is designed as the basic surface roughness prediction model that uses tool wear conditions and sensor signals as the input. The transfer learning strategy is applied on SAE-LSTM such that the surface roughness online prediction under variable cutting parameters can be realized. Machining experiments for the assembly interface (Ti6Al4V material) of the aircraft’s vertical tail are conducted and the monitoring data are used to validate the proposed method. Ablations studies are carried out to evaluate the key modules of the proposed model. The experimental results show that the proposed method outperforms other models and well track the true surface roughness over time.
Impact of Various Types of Polluted Water, Rhizome Size and Water Depth on Sprouting of Common Cattail (Typha latifolia L.) Rhizomes
Authors: Gul Bakhtiar , Ghayasuddin Alma , Khan Haroon , Khan Imtiaz , Khan Muhammad Ishfaq 
Published: December 2021

Abstract
Three different studies were carried out in the Department of Weed Science, The University of Agriculture Peshawar, in January 2016 to examine the impacts of polluted water from various sources, water depths and rhizome size on the resprouting ability and establishment of common cattail rhizomes fragments after mechanical control. These experiments were arranged in Completely Randomized Design (CRD), replicated thrice. The selected experimental units were pots 20 inches wide and 12 inches deep. Typha latifolia L. rhizomes were placed in each pots and covered with a little silt to avoid it’s direct contact and desiccation from sunlight. The impacts of water quality on T. latifolia rhizomes sprouting were significant. Lowest ratio of sprouted and un-sprouted buds (50.00 % each), 1st sprout length (37.33 and 40 cm), average sprout length (17.47 and 16.96 cm), average biomass (9.99 and 10.27 g) and growth rate (0.172 and 0.196 g/day) were noted for saline water and industrial acidic effluents, respectively. However, highest rhizome sprouting was recorded for tap water applied as check followed by industrial effluent alkaline. The data regarding the impact of water depth on T. latifolia rhizome sprouting showed that sprouting (44.44 %), 1st sprout length (43.33 cm), average sprout length (20.99 cm), average sprout biomass (7.84 g), average diameter of the newly formed rhizome (0.24 cm) and growth rate (0.4233 g/day) were recorded for rhizomes placed at zero level water depth, while maximum buds sprouted at 4 inches water depth. Similarly, impact of rhizome size on resprouting revealed that minimum bud sprouting (44.44%), 1st sprout length (44.86 cm), average sprout length (0.93 cm) and biomass of newly formed rhizome (4.97 g) and minimum days to emergence (9) were noted for smaller rhizome length (2 buds) compared to longer rhizomes with 10 buds. Therefore, on the basis of our findings, saline and industrial effluent acidic, no standing water (zero water surface level) and shorter rhizome size resulted in least bud sprouting and minimized the chance of further infestation in an eco-friendly and ecological way without the use of herbicides. Whereas alkaline industrial effluents, standing water up to 4 inches and longer rhizome fragments enhanced sprouting and re-establishment of the T. latifolia and these strategies can be utilized where the aim is to grow and establish a good stand of T. latifolia for passive treatment and phytoremediation of industrial effluents, before draining the polluted water into fresh water bodies like rivers and streams.
Bioindication of Heavy Metals in a Waterfall Outflow Using a Bryophyte Community
Authors: Printarakul Narin , Meeinkuirt Weeradej 
Published: December 2021

Abstract
Huay Pah Lahd stream in Doi Suthep-Pui National Park, Thailand, is potentially vulnerable to nearby anthropogenic activities. In this study, we determined heavy metal accumulation in bryophyte tissue and their growth substrates. Enrichment factors (EFs) of heavy metals were employed to monitor concentrations in bryophyte tissue. Of eight bryophyte taxa investigated, Scopelophila cataractae showed the highest capacity to accumulate metals in tissue, particularly Fe, Zn, Cd and Cu in protonemata (8,026.7, 1,187.2, 16.9 and 530.1 mg kg-1, respectively). Furthermore, the endangered and rare bryophyte taxa S. cataractae and Porella acutifolia were found intermingled with other urban and common aquatic bryophytes. These taxa might be considered sensitive warning organisms for heavy metal stress in stream ecosystems induced by environmental pollution. Because EFs of all heavy metals were < 2, this suggests that natural processes are the key source of heavy metals; furthermore, the environment of this National Park was identified as being heathy, and an important ecosystem buffer and biodiversity haven.
Nutritional Support With Oral Polymeric Formulation Enriched With Transforming Growth Factor beta 2 (TGF-β2) in Allogenic Hematopoietic Stem Cells Transplantation (Allo-hsct): A Prospective Interventional Study
Authors: Arena Francesco , Enrico Morello , Alessandro Turra , Michele Malagola , Mirko Farina , Nicola Polverelli , Elsa Cavagna , Manuel Meris , Lisa Gandolfi , Tatiana Zollner , Eugenia Accorsi Buttini , Chiara Ricci , Alessandro Leoni , Emanuela Samarani , Alice Bertulli , Bernardi Simona , Domenico Russo 
Published: December 2021

Abstract
PurposeIn the allogeneic transplant setting (allo-HSCT), the prevalence of malnutrition at admission is usually low, but at discharge, may be 60% or more and it may affect the transplant outcome.The aim of this study was to reduce the incidence of severe malnutrition (PG-SGA C) at day + 28 days from allo-HSCT in patients supported with an oral polymeric formulation enriched with Transforming Growth Factor beta 2 (TGF-β2).MethodsFifty-one patients were consecutively enrolled between March 2020 and June 2021 in this prospective interventional study. As a group of control, we have retrospectively analyzed an observational cohort composed by thirty patients submitted to allo-HSCT from august 2017 and august 2018 in our institution.ResultsThe incidence of severe malnourished patients (PG-SGA C) at + 28 days was significantly lower in the group with an oral nutritional support (ONS) treatment ratio (TR) major than 50% (TR>50%) in comparison to the ones with less than 50% ONS assumption (TR<50%) (13% vs 88.9% P=0.000). Interestingly, cumulative incidence of gastrointestinal (GI) aGVHD was significantly lower in patients assuming 50% or more of the prescribed ONS dose in comparison to those who assumed less than 50% of ONS (0%, vs 29.6%; p=0.005). Pneumonia was more frequent in patients with TR < 50% compared to patients with TR > 50% (48.1 % and 12.5 % respectively)(p=0.006).ConclusionMODULEN-IBD® seems to be a promising ONS to reduce malnutrition in allogeneic stem cell transplantation and should be tested in a randomized controlled prospective trial. MODULEN-IBD® may also have some positive immunological effects on gastrointestinal GVHD and infections that should be explored in larger studies.
The Medical Student Experience in the Era of COVID-19: Reflections on the Transformation of Medical Education
Authors: Terry Aisha , Miller Janet , Rodriguez Stephanie , Haley Mairin , Ben-Maimon Sivan , Knowles Jessenia , Wahrenbrock Taylor , Photovath Jai , Duggal Neel 
Published: December 2021

Abstract
Phenomenon:

The American medical student perspective on the coronavirus pandemic, particularly in terms of its effects on medical education and future curricular approach, is valuable. This study seeks to provide future physicians with a voice to share their personal experience with distance learning and suggestions for medical education reform in the era of COVID-19.
Approach:

A virtual focus group of medical students was conducted on April 30, 2020. Each student was asked to broadly and candidly reflect on their personal experiences relative to the COVID-19 pandemic, and to specifically expound upon how their personal growth and medical education has been impacted. Consent was obtained. Data was coded by key ideas and themes. The content of the discussion was analyzed.
Findings:

Seven third-year medical students attending a United States traditional school of medicine consented to participate. All participants provided extensive responses to the question. The focus group lasted for 2 hours. The group expounded upon five self-initiated themes: guilt, anxiety, self-awareness, volunteerism, and autonomy. Analysis of these themes from the context of medical student wellness and the future of medical curricula led to the conclusion that three general concepts should be emphasized in reforming medical education.
Insights:

The coronavirus pandemic has uniquely affected medical students. Their perspectives can inform medical education reform relative to curricular design and student wellness. Key concepts to consider include prioritizing routine virtual delivery of content through innovative technology, encouraging increased student autonomy and self-directed learning through less prescriptive schedules, and emphasizing reflection training and sharing.
The in vitro antimicrobial and antioxidant activity of leaves of medicinal plants with phytobiotic potential in animal production
Authors: Aroche Roisbel , Jiang Xianren , Martínez Yordan , Rodríguez Román , Li Xilong , Arévalo Ana Carolina , Avellaneda Mavir Carolina 
Published: December 2021

Abstract
Little is known about which secondary metabolites are responsible for inhibiting pathogenic bacteria and reducing the pro-oxidant effect on the leaves of four medicinal plants used as phytobiotic in animal production. The aim of this study was to evaluate the antimicrobial and antioxidant activity of four medicinal plants (Anacardium occidentale, Psidium guajava, Morinda citrifolia and Moringa oleifera.) in vitro. A total of six bacterial strains were inoculated, then minimum bactericidal concentration (MBC) was evaluated in fine powder and minimum inhibitory concentration (MIC) and MBC were determined on the aqueous extract. Also, the in vitro antioxidant activity was evaluated through 1,1-diphenyl-2-picryl-hydrazyl, as well as the main secondary metabolites were identified and quantified by chromatographic analysis. The results showed that Anacardium occidentale and Psidium guajava leaves had higher antimicrobial activity against all bacterial strains. In addition, Morinda citrifolia inhibited S. aureus in the aqueous extract, although without in vitro bactericidal effect, while Moringa oleifera leaf did not show antimicrobial effect. All plants showed antioxidant capacity, standing out Anacardium occidentale and Psidium guajava. Mainly the leaves of Anacardium occidentale showed high concentrations of quercetin 3-O-glucoside-7-O-rhamnoside, kaempeferol-7-O-glucoside, quercetin, caffeic acid, and cinnamic acid. Apparently, the antimicrobial and antioxidant activity are due to the main polyphenolic compounds identified in medicinal plants (mainly Anacardium occidentale and Psidium guajava); however, further studies are necessary to elucidate the exact mechanism.
The role of social assistance program on management accounting practice
Authors: Sholichatun Mira Fajrin , Apriyanti Hani Werdi 
Published: December 2021

Purpose - The purpose of this study is to determine the procurement of social assistance program on management accounting practice of MSMEs in food industry sector in Semarang during the Covid-19 pandemic.Method - The population in this study was 17,602 MSMEs in Semarang. The research samples were 144 MSMEs in the food industry sector in Semarang obtained using a non-random sampling technique with a purposive sampling method. The data were then processed using descriptive analysis, data quality test, classic assumption test, simple regression analysis, and hypothesis test with IBM SPSS 25 software.Result - The results show that procurement of social assistance program affected management accounting practice of MSMEs in the food industry sector in Semarang during the Covid-19 pandemic.Implication - The results show that with the support provided by the government and financial institutions in the form of social assistance programs to MSMEs had positive impacts by encouraging MSMEs to implement management accounting practices during the covid-19 pandemic.Originality - Procurement of Social Assistance Program is an independent variable which is later expected to be able to overcome MSME problems due to the financing faced by MSMEs in Semarang in response to the impact of Covid-19 pandemic.