bluuebunny/crossref_metadata_2025_split huggingface dataset:
WYKORZYSTANIE NARZĘDZI INFORMATYCZNYCH W PRACY Z LEKTURAMI NA POZIOMIE A1/A2, CZYLI JAK MOŻNA KSZTAŁTOWAĆ SPRAWNOŚĆ CZYTANIA ZE ZROZUMIENIEM W NAUCZANIU ZDALNYM
Authors: Gierzyńska Marta 
Published: December 2021

Refining reading comprehension skills is one of the basic tasks that students of foreign languages and their teachers face. Some of the texts offered in students’ books do not make pupils interested in the topic, motivated or encouraged enough to develop their reading comprehension ability. The reason is that these texts are compulsory students have to read them which thus makes the readings less interesting. Learning foreign languages essentially should be focused on their posterior use in extracurricular, personal and then occupational conditions. Since reading is necessary, then choosing simple books in a foreign language would be worth considering. Such texts may be perceived by the students differently from the compulsory readings in class. What is more, reading didactically adapted, longer literary texts and their proper reception will certainly be satisfying for the student. This article provides the reader with the examples of using simplified readings in the global and detailed text processing which, in turn, takes into account techniques such as pre-reading, while-reading and post-reading. Furthermore, the article presents the ideas of including Information and Communication Technologies in teaching which influences students’ engagement and allows the teacher to monitor their work.
Debt Security of CEE Countries: Actual Approaches and Methods of Evaluation
Authors: Chentukov Yurii , Marena Tetyana , Zakharova Olha 
Published: December 2021

The study is aimed at analyzing methods of country’s debt security evaluation, developing methodic approach towards estimating the level of debt security based on the calculation of the integral index, and assessing the level of debt security of CEE countries on the basis of the proposed approach. A method of calculating the integral debt security index of the country is developed, taking into account generally accepted thresholds of indebtedness and solvency indicators and the trend of countries’ increasing dependence on external borrowing.
The proposed approach is practically tested in assessing the level of debt security of CEE countries. It is determined that the group of CEE countries is differentiated by the state of indebtedness and solvency. The highest level of debt security is demonstrated by Bulgaria, the Czech Republic and Estonia, the worst situation with the debt security is formed in Slovakia and Slovenia. Based on the analysis of the dynamics of integral debt security indices for 2007–2019, the grouping of CEE countries by the level and zones of debt security, the trends of deterioration of the region’s debt security in 2010–2015 and its improvement in 2016–2019 has been found out. The proposed approach is universal one; it can be used to calculate debt security indices and to provide comparative studies of the debt sector of any country or region. It can also help to identify weaknesses in country’s debt security that is critically important for reasoning the public policy measures to ensure a proper level of debt security.
Russian Strategic Culture: Why the Past Matters
Authors: Doroshko Mykola , Tsyrfa Iuliia 
Published: December 2021

Today, strategic culture becomes an essential element of the national security policy of the Russian Federation. While absorbing some modern aspects, its strategic culture reflects historical lessons learnt by the Russian Empire and the USSR. Russia still cannot refuse from the idea to restore its superpower status and to fight for new territories. Thus, we can define a number of essential elements of the Russian strategic culture formed in relation to the historical and contemporary development of this state. Throughout the history, the Russians have legitimized the decisions and activities of the ruling elites. As the Russian leadership has long built up powerful associations which had taken root in the minds of people while remembering patriotism and love for their Motherland, the Russians believe in the importance of maintaining and enhancing patriotic feelings. While cultivating its civilizational and cultural detachment, Russia continues developing its own messianic idea which envisages the views of the special historical kismet of Russia. In order to fulfill its global tasks, Russia uses the policy of military interventions and violates state sovereignty of other countries, since the ‘militant’ political culture of its leaders has always militarized the strategic culture of the RF.
So, the strategic culture of Russia emanates from the unique position and history of this state which manages to adapt it to the new realities. However, Russia’s aspirations to reclaim its status as a global superpower at any cost do not allow its strategic culture to be changed or even to be altered.
POCT errors can lead to false potassium results
Authors: Buño Antonio , Oliver Paloma 
Published: December 2021

AbstractPoint-of-care-testing (POCT) facilitates rapid availability of results that allows prompt clinical decision making. These results must be reliable and the whole process must not compromise its quality. Blood gas analyzers are one of the most used methods for POCT tests in Emergency Departments (ED) and in critical patients. Whole blood is the preferred sample, and we must be aware that hemolysis can occur. These devices cannot detect the presence of hemolysis in the sample, and because of the characteristics of the sample, we cannot visually detect it either. Hemolysis can alter the result of different parameters, including potassium with abnormal high results or masking low levels (hypokalemia) when reporting normal concentrations. Severe hyperkalemia is associated with the risk of potentially fatal cardiac arrhythmia and demands emergency clinical intervention. Hemolysis can be considered the most frequent cause of pseudohyperkalemia (spurious hyperkalemia) or pseudonormokalemia and can be accompanied by a wrong diagnosis and an ensuing inappropriate clinical decision making. A complete review of the potential causes of falsely elevated potassium concentrations in blood is presented in this article. POCT programs properly led and organized by the clinical laboratory can help to prevent errors and their impact on patient care.
IgE multiple myeloma: detection and follow-up
Authors: Nafría Jiménez Beatriz , Oliveros Conejero Raquel 
Published: December 2021

Abstract

Objectives
We report a new case of immunoglobulin E multiple myeloma (IgE), a very rare isotype that accounts for <0.1% of cases of this monoclonal gammopathy. To ensure the adequate detection, quantification and identification of the monoclonal component, it is crucial that protein assays are performed. We provide some clues related to clinical laboratory results, which will facilitate an adequate management of the disease.

Case presentation
A 45-year-old patient with a five-week history of pain at the level of the elbow, who was diagnosed with IgE-Kappa multiple myeloma based on laboratory, radiological, and bone marrow findings. The patient received induction chemotherapy prior to hematopoietic stem-cell transplantation and is currently on follow-up.

Conclusions
Protein assays performed in the clinical laboratory, including protein electrophoresis and immunofixation, allowed for the detection of an IgE-Kappa monoclonal component prior to the appearance of the typical CRAB symptoms (hypercalcemia, renal involvement, anemia, and bone pain) of multiple myeloma (MM). The detection of IgE-Kappa facilitated early diagnosis and management.
Bacteremia caused by Helicobacter cinaedi: a case report
Authors: Sidak Kateryna , Pérez-Tanoira Ramón , Gomez-Herruz Peña 
Published: December 2021

Abstract

Objectives

Helicobacter cinaedi is a Gram-negative, spiral-shaped bacterium that primarily affects immunosuppressed patients.

Case presentation
A 49-year-old patient with ulcerative colitis diagnosed in 1992, who presented to the ED of our hospital with fever and testicular complaints. The patient was discharged with a diagnosis of left-sided acute epididymitis, which was probably sexually transmitted. At the ED, he was administered intravenous Ceftriaxone and discharged with a prescription of doxycycline for 10 days, with a good progress. Aerobic cultures were positive at three days from collection. Gram staining showed Gram-negative, corkscrew-shaped bacteria. The analysis of the blood culture bottles, and the colonies grown in Campylosel agar incubated in microaerophilic conditions at 42 °C were identified as H. cinaedi on the Maldi-TOF Biotyper 3.0 system (Bruker Diagnostics Inc.).

Conclusions
Direct analysis of the blood culture bottle on the Maldi-TOF system allowed for the identification of the etiology of the bacteremia since H. cinaedi could not have been grown in standard culture conditions. The treatment of this infection is a matter of debate; however, the combination of ceftriaxone with doxycycline can be ineffective for bacteremia caused by H. cinaedi infection since it occurs by the translocation of the bacteria from the gastrointestinal tract. This type of bacteremia is associated with intestinal mucosal damage secondary to ulcerative colitis, and it primarily affects immunosuppressed patients.
Method comparison of three serum free light chain assays on the Roche Cobas 6000 c501 chemistry analyzer
Authors: Augustijn Dieuwertje , Jacobs Joannes F.M. , Russcher Henk 
Published: December 2021

Abstract

Objectives
Free light chains (FLC) are important in the diagnosis, prognosis and monitoring of therapy response of patients with monoclonal gammopathies. In this study, we performed a method comparison of three FLC assays on the Cobas 6000 c501 chemistry analyzer of Roche Diagnostics.

Methods
Samples of 119 patients with various monoclonal gammopathies and 26 control patients were measured with the Freelite (The Binding Site), Diazyme (Diazyme Laboratories) and KLoneus (Trimero Diagnostics) FLC assays. A method comparison was performed and reference intervals of the three assays were validated.

Results
The analysis of the Bland-Altman agreement showed bias between the three FLC assays, ranging from −62.7 to 5.1% for κFLC and between −29.2 to 80.5% for λFLC. The Freelite and Diazyme assays have the highest agreement. The concordance of the FLC-ratio ranges from 41 to 75%, with the highest concordance between the Freelite and KLoneus assays. The FLC-ratio in 25 sera from healthy controls were within the reference ranges of the Freelite and KLoneus assays. The FLC-ratio was elevated in all 25 samples tested with the Diazyme assay.

Conclusions
The agreement for the free light chains is highest between the Freelite and the Diazyme assay and fair for the KLoneus assay. However, concordance of the FLC-ratio is highest when the Freelite and KLoneus assays were compared. Our data suggest that concordance for the Diazyme assay could be improved by recalibration. Because of absolute differences between the three methods in individual patients, none of the three FLC assays can be used interchangeably.
Determinants of birth-intervals in Algeria: a semi-Markov model analysis
Authors: Chellai Fatih 
Published: December 2021

AbstractObjectivesAnalyzing the dynamics and patterns of birth intervals in the Algerian population is an important issue in developing an effective population policy. In this study, we attempted to estimate the effects of socioeconomic and demographic factors on the birth spacing process.MethodsSemi-Markov models were used, based on data from the Multiple Indicator Cluster Survey (MICS), where the birth histories of 13,453 infants nested within a sample of 6,958 married women were analyzed.ResultsThe findings stated that the birth intervals depend on: (i) mothers’ educational level, whereas wider intervals have been found for highly educated women, (ii) the wealth index, as women from poor families have short birth intervals, and (iii) there was no clear difference between rural and urban areas.ConclusionsPolicymakers can act through these axes to develop more efficient strategies for family planning.
The Impact of Eye Closure on Anticipatory α Activity in a Tactile Discrimination Task
Authors: ElShafei Hesham A. , Orlemann Corinne , Haegens Saskia 
Published: December 2021

AbstractOne of the very first observations made regarding α oscillations (8–14 Hz), is that they increase in power over posterior areas when awake participants close their eyes. Recent work, especially in the context of (spatial) attention, suggests that α activity reflects a mechanism of functional inhibition. However, it remains unclear how eye closure impacts anticipatory α modulation observed in attention paradigms, and how this affects subsequent behavioral performance. Here, we recorded magnetoencephalography (MEG) in 33 human participants performing a tactile discrimination task with their eyes open versus closed. We replicated the hallmarks of previous somatosensory spatial attention studies: α lateralization across the somatosensory cortices as well as α increase over posterior (visual) regions. Furthermore, we found that eye closure leads to (1) reduced task performance; (2) widespread increase in α power; and (3) reduced anticipatory visual α modulation (4) with no effect on somatosensory α lateralization. Regardless of whether participants had their eyes open or closed, increased visual α power and somatosensory α lateralization improved their performance. Thus, we provide evidence that eye closure does not alter the impact of anticipatory α modulations on behavioral performance. We propose there is an optimal visual α level for somatosensory task performance, which can be achieved through a combination of eye closure and top-down anticipatory attention.
Cortical Granularity Shapes the Organization of Afferent Paths to the Amygdala and Its Striatal Targets in Nonhuman Primate
Authors: McHale A. C. , Cho Y. T. , Fudge J. L. 
Published: December 2021

The prefrontal cortex (PFC) and insula, amygdala, and striatum form interconnected networks that drive motivated behaviors. We previously found a connectional trend in which granularity of the ventromedial and orbital PFC/insula predicted connections to the amygdala, and also the breadth of amygdalo-striatal efferents, including projections beyond the “classic” ventral striatum. To further interrogate connectional relationships among the cortex, amygdala, and striatum, and to further define the “limbic” (amygdala-recipient) striatum, we conducted tract tracing studies in two cohorts of macaques (malen= 14, femalen= 1). We focused on the cortico-amygdalo-striatal (indirect) and cortico-“limbic” striatal (direct) paths originating in the entire PFC and insula. Larger datasets and a quantitative approach revealed “cortical rules” in which cortical granularity predicts the complexity and location of projections to both the basal nucleus of the amygdala and striatum. Remarkably, projections from “cortical-like” basal nucleus to the striatum followed similar patterns. In both “direct” and “indirect” paths to the “limbic” striatum, agranular cortices formed a “foundational,” broad projection, and were joined by inputs from progressively more differentiated cortices. In amygdalo-striatal paths, the ventral basal nucleus was the “foundational” input, with progressively more dorsal basal nucleus regions gradually adding inputs as the “limbic” striatum extended caudally. Together, the “indirect” and “direct” paths followed consistent principles in which cortical granularity dictated the strength and complexity of projections at their targets. Cluster analyses independently confirmed these connectional trends, and also highlighted connectional features that predicted termination in specific subregions of the basal nucleus and “limbic” striatum.SIGNIFICANCE STATEMENTThe “limbic” system broadly refers to brain circuits that coordinate emotional responses. Here, we investigate circuits of the amygdala, which are involved in coding the emotional value of external cues, and their influence on the striatum. Regions of prefrontal cortex (PFC) and insula form gradients of overlapping inputs to the amygdala's basal nucleus, which feed forward to the striatum. Direct cortical inputs to these “amygdala-recipient” striatal areas are surprisingly organized according to similar principles but subtly shift from the “classic” ventral striatum to the caudal ventral striatum. Together, these distinct subsystems, cortico-amygdalo-striatal circuits and direct cortico-striatal circuits, provide substantial opportunity for different levels of internal, sensory, and external experiences to be integrated within the striatum, a major motor-behavioral interface.
Mlc1-Expressing Perivascular Astrocytes Promote Blood–Brain Barrier Integrity
Authors: Morales John E. , De Arpan , Miller Alexandra A. , Chen Zhihua , McCarty Joseph H. 
Published: December 2021

In the mammalian brain, perivascular astrocytes (PAs) closely juxtapose blood vessels and are postulated to have important roles in the control of vascular physiology, including regulation of the blood–brain barrier (BBB). Deciphering specific functions for PAs in BBB biology, however, has been limited by the ability to distinguish these cells from other astrocyte populations. In order to characterize selective roles for PAsin vivo, a new mouse model has been generated in which the endogenous megalencephalic leukoencephalopathy with subcortical cysts 1 (Mlc1) gene drives expression of Cre fused to a mutated estrogen ligand-binding domain (Mlc1-T2A-CreERT2). This knock-in mouse model, which we term MLCT, allows for selective identification and tracking of PAs in the postnatal brain. We also demonstrate that MLCT-mediated ablation of PAs causes severe defects in BBB integrity, resulting in premature death. PA loss results in aberrant localization of Claudin 5 and -VE-Cadherin in endothelial cell junctions as well as robust microgliosis. Collectively, these data reveal essential functions for Mlc1-expressing PAs in regulating endothelial barrier integrity in mice and indicate that primary defects in astrocytes that cause BBB breakdown may contribute to human neurologic disorders.SIGNIFICANCE STATEMENTInterlaced among the billions of neurons and glia in the mammalian brain is an elaborate network of blood vessels. Signals from the brain parenchyma control the unique permeability properties of cerebral blood vessels known as the blood–brain barrier (BBB). However, we understand very little about the relative contributions of different neural cell types in the regulation of BBB functions. Here, we show that a specific subpopulation of astrocyte is essential for control of BBB integrity, with ablation of these cells leading to defects in endothelial cell junctions, BBB breakdown, and resulting neurologic deficits.
Discovery Learning Model on Mathematics Learning at Islamic Private Junior High School Darussalam
Authors: Syafti Okviani 
Published: December 2021

The study aims to determine whether the mathematics learning outcomes of students who learn discovery learning are better than students who learn conventionally. It also aims to find out whether the mathematics learning outcomes of students with high initial abilities and low initial abilities with discovery learning are better than students who learn conventionally. This type of research is a Quasi Experiment with quantitative approach design and used was a randomized control group only design with treatment by blocks. The population in this study were students of class VII Islamic private junior high school or MTsS Darussalam Ampiang Parak, Sutera Sub District, Pesisir Selatan. The research sample was randomly selected,namely students of class VII.1 as the experimental class and VII.2 as the control class. The research data were obtained from the results of the initial ability test and the final test given after the experiment was carried out. Data analysis using t test.The results of the analysis show that: 1) The mathematics learning outcomes of students with discovery learning model are better than those taught by conventional learning, 2) Mathematics learning outcomes of students with high initial abilities and students with low initial abilities with discovery learning learning models of learning arebetter than students with high initial abilities. taught by conventionallearning. The results could be a solution for teachers to provide learning to develop students' ability invention, especially in the discovery of mathematical concepts and problem solving both in learning and in daily life
Design of a roll crusher for sunflower stems and substantiation of the rational modes of its operation
Authors: Sheichenko Viktor , Volskyi Volodymyr , Kotsiubanskyi Rostyslav , Dnes Viktor , Shevchuk Misha , Bilovod Oleksandra , Drozhchana Olga 
Published: December 2021

This paper reports a study of the technological process of grinding plant residues of sunflower and the causal relationships of factors that form the system of quality indicators. The necessary prerequisites for determining rational modes and parameters of the roll crusher have been devised.
A prototype of the roll crusher was designed and fabricated, in which the cutting knives are arranged along the entire width of the grip in a staggered manner, with the possibility to change the angle of inclination to the axis of drum rotation in the range of 5...20°.
It was established that in the case of the right-side arrangement of the cutting edge of knives, the highest total level of the percentage of crushed stems in the range of 101‒150 mm with an additional load weighing 800 kg exceeded by 1.58 times the corresponding indicators of the roll with an additional load of 600 kg. The largest overall value of the percentage of crushed stems in the range of 0‒200 mm when additionally loading the roll with 800 kg was 1.13 times higher than the corresponding indicators of the roll with an additional load of 600 kg.
In the range of 0‒200 mm, with an additional load on the roll of 600 kg, at the left-side arrangement of the cutting edge of the knives of the roll, higher total percentage of crushed stems was observed compared to the right-side arrangement. At a speed of 7.45 km/h, 13.6 km/h, the cumulative value of the percentage of crushed stems exceeded the corresponding indicators at the right-side arrangement of knives by 1.09 times, at the speed of 18.6 km/h – by 1.04 times, at the speed of 22 km/h – by 1.04 times, respectively.
It has been noted that at the left-side arrangement of the cutting edge of the knives of the roll, the percentage of crushed stems in the range of 51‒100 mm, with an additional load of 600 kg, exceeded the corresponding indicators with an additional load of 800 kg. At the speed of 10.08 km/h, it was exceeded by 1.9 times; at the speed of 13.6 km/h – by 1.44 times; at the speed of 18.6 km/h – by 1.96 times; at the speed of 22 km/h – by 1.99 times, respectively