bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiological measurement of cochlear dimensions in cochlear hypoplasia and its effect on cochlear implant selection
Authors: Pamuk G , Pamuk A E , Akgöz A , Bajin M D , Özgen B , Sennaroğlu L 
Published: April 2021

AbstractObjectiveTo determine the effect of cochlear dimensions on cochlear implant selection in cochlear hypoplasia patients.MethodsTemporal bone computed tomography images of 36 patients diagnosed with cochlear hypoplasia between 2010 and 2016 were retrospectively reviewed and compared with those of 40 controls without sensorineural hearing loss.ResultsBasal turn length and mid-modiolar height were significantly lower in the cochlear hypoplasia patients with subtypes I, II and III than in the control group (p < 0.001). Mid-scalar length was significantly shorter in subtype I–III patients as compared with the control group (p < 0.001). In addition, cochlear canal length (measured along the lateral wall) was significantly shorter in subtype I–IV patients than in the control group (subtypes I–III, p < 0.001; subtype IV, p = 0.002)ConclusionCochlear hypoplasia should be considered if basal turn length is less than 7.5 mm and mid-modiolar height is less than 3.42 mm. The cochlear implant should be selected according to cochlear hypoplasia subgroup. It is critically important to differentiate subtype II from incomplete partition type I and subtype III from a normal cochlea, to ensure the most appropriate implant electrode selection so as to optimise cochlear implantation outcomes.
Genetic diversity of marbled goby populations in the Anatolian coasts of the north-eastern Mediterranean
Authors: Seyhan-Ozturk Dilruba , Engin Semih 
Published: April 2021

AbstractThe demographic histories, genetic relationships and population structure of sedentary fishPomatoschistus marmoratus(Risso, 1810), which was sampled from the north-eastern basin of the Mediterranean Sea (including the Turkish coasts of the Black Sea, Aegean Sea, Levantine Sea and Sea of Marmara), were investigated by mitochondrial cytochrome c oxidase subunit I (652 bp) and cytochrome b (526 bp) regions. It was found that the population groups had high haplotype diversity while the nucleotide diversity was quite low for both gene regions. Phylogeographic analyses of the haplotypes indicated that the Levantine population (LEV) were genetically different from other populations. Also, the gene flow between LEV and the other populations was very limited. The results of the analyses of neutrality and mismatch distributions that were applied to the population groups were evaluated as a whole. It was determined that the haplogroup that represents the Black Sea and Sea of Marmara populations (BLAMAR) was stable, but the Levantine population (LEV) was under the sudden demographic expansion model following the population bottleneck. The genetic variance indices indicated sudden demographic expansion following population contraction. This was supported by star-shaped haplotype networks. The reason for this limited gene flow and differentiation between the Levantine population (LEV) and the others was linked with wind-driven offshore transport of the larvae and surface currents in these sub-basins. The timing of the differentiation, demographic histories of populations associated with geological and palaeo-climatic events and current ecological conditions were discussed.
Lessons from practitioners for designing and implementing effective amphibian captive breeding programmes
Authors: Karlsdóttir Berglind , Knight Andrew T. , Johnson Kevin , Dawson Jeff 
Published: April 2021

AbstractWith 40% of global amphibian species threatened with extinction, captive breeding programmes are an increasingly important conservation tool. The highest priority species occur in tropical countries, which presents a number of challenges. We conducted semi-structured interviews with 25 practitioners in Latin America, Africa and Asia to investigate how the effectiveness of amphibian captive breeding programmes could be improved. A thematic analysis identified 94 barriers and enablers across 13 themes. We found that existing programmes commonly followed a reactive and often ineffective four-stage operational model. Subsequently, we developed a proactive operational model, using the barriers and enablers identified by this study, to support programme managers in the implementation of effective programmes. Our findings suggest human dimensions are often critical barriers or enablers across all stages of captive breeding programmes. We recommend the development of strategic partnerships between institutions, including zoos, NGOs, governments and captive breeding programmes, to help overcome these critical barriers and improve the effectiveness of global amphibian conservation. This operational model could be translated to captive breeding programmes for other taxa.
Molecular phylogeny and new light microscopic data ofMetchnikovella spiralis(Microsporidia: Metchnikovellidae), a hyperparasite of eugregarinePolyrhabdinasp. from the polychaetePygospio elegans
Authors: Frolova Ekaterina V. , Paskerova Gita G. , Smirnov Alexey V. , Nassonova Elena S. 
Published: April 2021

AbstractMetchnikovellids are a deep-branching group of microsporidia, parasites of gregarines inhabiting the alimentary tract of polychaetes and some other invertebrates. The diversity and phylogeny of these hyperparasites remain poorly studied. Modern descriptions and molecular data are still lacking for many species. The results of a light microscopy study and molecular data forMetchnikovella spiralisSokolova et al., 2014, a hyperparasite of the eugregarinePolyrhabdinasp., isolated from the polychaetePygospio elegans, were obtained. The original description ofM. spiraliswas based primarily on the analysis of stained preparations and transmission electron microscopy images. Here, the species description was complemented with the results ofin vivoobservations and phylogenetic analysis based on the SSU rRNA gene. It was shown that in this species, free sporogony precedes sac-bound sporogony, as it occurs in the life cycle of most other metchnikovellids. Spore sacs are entwined with spirally wound cords, and possess only one polar plug. Phylogenetic analyses did not groupM. spiraliswithM. incurvata, another metchnikovellid from the same gregarine species, but placed it as a sister branch toAmphiacantha. The paraphyletic nature of the genusMetchnikovellawas discussed. The taxonomic summary forM. spiraliswas emended.
Immunological underpinnings of Ascaris infection, reinfection and co-infection and their associated co-morbidities
Authors: Magalhães Luisa , Nogueira Denise S. , Gazzinelli-Guimarães Pedro H. , Oliveira Fabricio M. S. , Kraemer Lucas , Gazzinelli-Guimarães Ana Clara , Vieira-Santos Flaviane , Fujiwara Ricardo T. , Bueno Lilian L. 
Published: April 2021

AbstractHuman ascariasis is the most common and prevalent neglected tropical disease and is estimated that ~819 million people are infected around the globe, accounting for 0.861 million years of disability-adjusted life years in 2017. Even with the existence of highly effective drugs, the constant presence of infective parasite eggs in the environment contribute to a high reinfection rate after treatment. Due to its high prevalence and broad geographic distribution Ascaris infection is associated with a variety of co-morbidities and co-infections. Here, we provide data from both experimental models and humans studies that illustrate how complex is the interaction of Ascaris with the host immune system, especially, in the context of reinfections, co-infections and associated co-morbidities.
What is a mental disorder? An exemplar-focused approach
Authors: Stein Dan J. , Palk Andrea C. , Kendler Kenneth S. 
Published: April 2021

AbstractThe question of ‘what is a mental disorder?’ is central to the philosophy of psychiatry, and has crucial practical implications for psychiatric nosology. Rather than approaching the problem in terms of abstractions, we review a series of exemplars – real-world examples of problematic cases that emerged during work on and immediately after DSM-5, with the aim of developing practical guidelines for addressing future proposals. We consider cases where (1) there is harm but no clear dysfunction, (2) there is dysfunction but no clear harm, and (3) there is possible dysfunction and/or harm, but this is controversial for various reasons. We found no specific criteria to determine whether future proposals for new entities should be accepted or rejected; any such proposal will need to be assessed on its particular merits, using practical judgment. Nevertheless, several suggestions for the field emerged. First, while harm is useful for defining mental disorder, some proposed entities may require careful consideration of individualv.societal harm, as well as of societal accommodation. Second, while dysfunction is useful for defining mental disorder, the field would benefit from more sharply defined indicators of dysfunction. Third, it would be useful to incorporate evidence of diagnostic validity and clinical utility into the definition of mental disorder, and to further clarify the type and extent of data needed to support such judgments.
Coronavirus conspiracy suspicions, general vaccine attitudes, trust and coronavirus information source as predictors of vaccine hesitancy among UK residents during the COVID-19 pandemic
Authors: Allington Daniel , McAndrew Siobhan , Moxham-Hall Vivienne , Duffy Bobby 
Published: April 2021

AbstractBackgroundVaccine hesitancy presents an obstacle to the campaign to control COVID-19. It has previously been found to be associated with youth, female gender, low income, low education, low medical trust, minority ethnic group membership, low perceived risk from COVID-19, use of certain social media platforms and conspiracy beliefs. However, it is unclear which of these predictors might explain variance associated with others.MethodsAn online survey was conducted with a representative sample of 4343 UK residents, aged 18–75, between 21 November and 21 December 2020. Predictors of vaccine hesitancy were assessed using linear rank-order models.ResultsCoronavirus vaccine hesitancy is associated with youth, female gender, low income, low education, high informational reliance on social media, low informational reliance on print and broadcast media, membership of other than white ethnic groups, low perceived risk from COVID-19 and low trust in scientists and medics, as well as (to a much lesser extent) low trust in government. Coronavirus conspiracy suspicions and general vaccine attitudes appear uniquely predictive, jointly explaining 35% of variance. Following controls for these variables, effects associated with trust, ethnicity and social media reliance largely or completely disappear, whereas the effect associated with education is reversed.ConclusionsStrengthening positive attitudes to vaccination and reducing conspiracy suspicions with regards to the coronavirus may have a positive effect on vaccine uptake, especially among ethnic groups with heightened vaccine hesitancy. However, vaccine hesitancy associated with age and gender does not appear to be explained by other predictor variables tested here.
Lessons from the vaginal mesh scandal: enhancing the patient-centric approach to informed consent for medical device implantation
Authors: O'Neill Jennifer 
Published: April 2021

AbstractThe vaginal mesh scandal, in which thousands of women were irreversibly maimed by polypropylene mesh, revealed multilevel failures in medical device regulation and implantation, demonstrating that patient-centric care has not yet fully transcended from policy into practice. In law, informed consent is considered by a two-stage test: reasonable treatment and patient information disclosure. The standard of reasonable treatment is determined according to what is deemed acceptable in accordance with a body of medical opinion. However, such bodies of medical opinion were vulnerable to external influence from device manufactures. Vaginal mesh manufacturers were found to have had financial links to research, royal colleges, and influential clinicians, which then influenced the basis of the evidence-based practice that often guides such bodies of medical opinion. According to the Independent Medicines and Medical Device Safety Report, patients’ mesh complications were also frequently under-reported and patient-based evidence of harm disregarded. Patients were also not sufficiently informed of the material risks or reasonable alternatives to mesh, which is required of the second stage of informed consent pertaining to information disclosure. This paper makes the following recommendations: that conflict of interest disclosure be mandated, that greater value be afforded to patient-based evidence to improve evaluation of treatments, and that information disclosure for informed consent should relate to the risks, benefits, and alternatives to the surgical procedureandmedical device. This will ensure that patients can evaluate whether surgeons are offering unbiased treatment options and are also informed of the potential long-term risks associated with device implantation.
Are we there yet? A review of proposed Aboriginal cultural heritage laws in New South Wales, Australia
Authors: Lingard Kylie , Stoianoff Natalie P. , Wright Evana , Wright Sarah 
Published: April 2021

AbstractThis article examines the extent to which a recent law reform initiative in New South Wales (NSW), Australia—the draft Aboriginal Cultural Heritage Bill 2018 (NSW)—advances the general principles outlined in the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP). The examination reveals some improvements on the current legal framework and some concerning proposals that distance the NSW government from the UNDRIP principles. Key concerns include a proposed transfer of administrative responsibility to Aboriginal bodies with no corresponding guarantee of funding; the continued vesting of key decision-making powers in government; inept provisions for the protection of secret knowledge; and lower penalties for harming cultural heritage than for related offences in existing environmental and planning legislation. Given the bill’s weaknesses, the article explores pragmatic alternatives to better advance the UNDRIP principles.
Ten years of weekly epidemiological teleconference (EpiLag) – an effective and time-efficient tool for infectious disease event information, Germany, 2009–2018
Authors: Milde-Busch Astrid , Zeitlmann Nadine , Mücke Inge , Gilsdorf Andreas , Rexroth Ute , an der Heiden Maria ,   the EpiLag-Working Group
Published: April 2021

Abstract
In 2009, the Robert Koch Institute (RKI) and the 16 German federal state public health authorities (PHAs) established a weekly epidemiological teleconference (EpiLag) to discuss infectious disease (ID) events and foster horizontal and vertical information exchange. We present the procedure, discussed ID topics and evaluation results of EpiLag after 10 years. We analysed attendance, duration of EpiLag and the frequency of reported events. Participants (RKI and state PHA) were surveyed regarding their satisfaction with logistics, contents and usefulness of EpiLag (Likert scales). Between 2009 and 2018, RKI hosted 484 EpiLag conferences with a mean duration of 25 min (range: 4–60) and high participation (range: 9–16; mean: 15 PHAs). Overall, 2975 ID events (39% international, 9% national and 52% subnational) were presented (mean: 6.1 per EpiLag), most frequently on measles (18%), salmonellosis (8%) and influenza (5%). All responding participants (14/16 PHAs and 9/9 at RKI) were satisfied with the EpiLag's organization and minutes and deemed EpiLag useful for an overview and information distribution on ID events relevant to Germany. EpiLag is time efficient, easily applicable and useful for a low-threshold event communication. It supports PHAs in crises and strengthens the network of surveillance stakeholders. We recommend its implementation to other countries or sectors.
Association of human papillomavirus genotype distribution and cervical cytology: a cross-sectional study
Authors: Liu Fang , Chang Li , Bai Ting , Liu Xiaojuan , Hu Jinliang 
Published: April 2021

Abstract
The present study attempted to analyse human papillomavirus (HPV) genotype distribution and its association with cervical cytology results in women in western China. The present retrospective analysis was performed in 1089 female outpatients with a positive HPV test result who had undergone a cervical cytology test at the gynaecological clinic, West China Second Hospital, Sichuan University, China, between January 2014 and December 2016. Of the 1089 patients with HPV infection, multiple HPV genotypes were detected in 220 patients (20.20%). Among the 1368 HPV genotypes detected, 1145 (83.70%) were high-risk subtypes. The most common genotypes were HPV-52 (18.64%), HPV-16 (16.59%), HPV-58 (13.23%), HPV-18 (6.80%), HPV-56 (5.56%) and HPV-59 (5.56%). Cervical cytology revealed abnormal cells in 430 (39.49%) patients. The most common diagnoses were atypical squamous cells of undetermined significance (ASC-US; 236 cases, 54.88%), low-grade squamous intraepithelial lesions (LSIL; 151 cases, 35.12%), high-grade squamous intraepithelial lesions (HSIL; 63 cases, 14.65%) and atypical glandular cells (AGC; 21 cases, 4.88%). HPV-66 was significantly associated (P = 0.037) with ASC; HPV-52 and HPV-56 were significantly associated with LSIL (P = 0.009 and 0.026, respectively); HPV-16 (P < 0.001), HPV-33 (P = 0.014) and HPV-58 (P = 0.003) were significantly associated with HSIL; and HPV-16 (P = 0.005) was significantly associated with AGC. HPV-16, HPV-52 and HPV-58 are associated with different diagnoses in patients with positive cervical cytological findings.
Planned reduction in Fontan fenestration size using the Atrial Flow Regulator
Authors: Aregullin E. Oliver , Samuel Bennett , Vettukattil Joseph 
Published: April 2021

AbstractFontan fenestration allows right-to-left shunting increasing cardiac output and oxygen delivery. Increased shunting occurs as cardiac function and ventricular end-diastolic pressures improve, potentially decreasing oxygen saturation. Complete closure may result in impaired Fontan haemodynamics and low cardiac output; however, there are no dedicated devices to reduce fenestration size. We describe Fontan fenestration size reduction using the Atrial Flow Regulator.
Long-term neurodevelopmental effects of intraoperative blood pressure during surgical closure of a septal defect in infancy or early childhood
Authors: Lauritzen Daniel J. , Asschenfeldt Benjamin , Evald Lars , Hjortdal Vibeke E. , Heiberg Johan 
Published: April 2021

AbstractBackground:Many children born with congenital heart defects are faced with cognitive deficits and psychological challenges later in life. The mechanisms behind are suggested to be multifactorial and are explained as an interplay between innate and modifiable risk factors. The aim was to assess whether there is a relationship between mean arterial pressure during surgery of a septal defect in infancy or early childhood and intelligence quotient scores in adulthood.Methods:In a retrospective study, patients were included if they underwent surgical closure of a ventricular septal defect or an atrial septal defect in childhood between 1988 and 2002. Every patient completed an intelligence assessment upon inclusion, 14–27 years after surgery, using the Wechsler Adult Intelligence Scale Version IV.Results:A total of 58 patients met the eligibility criteria and were included in the analyses. No statistically significant correlation was found between blood pressure during cardiopulmonary bypass and intelligence quotient scores in adulthood (r = 0.138; 95% CI−0.133–0.389). Although amongst patients with mean arterial pressure < 40 mmHg during cardiopulmonary bypass, intelligence quotient scores were significantly lower (91.4; 95% CI 86.9–95.9) compared to those with mean arterial pressure > 40 mmHg (99.8; 95% CI 94.7–104.9).Conclusions:Mean arterial pressure during surgery of ventricular septal defects or atrial septal defects in childhood does not correlate linearly with intelligence quotient scores in adulthood. Although there may exist a specific cut-off value at which low blood pressure becomes harmful. Larger studies are warranted in order to confirm this, as it holds the potential of partly relieving CHD patients of their cognitive deficits.
Mechanical Turk and the “Don’t Know” Option
Authors: Brown Adam R. , Pope Jeremy C. 
Published: April 2021

ABSTRACTLuskin and Bullock’s (2011) randomized experiment on live-interview respondents found no evidence that American National Election Studies and Time-Sharing Experiments for the Social Sciences respondents hide knowledge behind the “don’t know” (DK) option. We successfully replicated their finding using two online platforms, the Cooperative Congressional Election Study and Google Surveys. However, we obtained different results on Amazon’s Mechanical Turk (MTurk). We attribute this difference to MTurkers’ experience with attention checks and other quality-control mechanisms, which condition them to avoid errors. This conditioning leads MTurkers to hide knowledge behind DK in ways not observed on other platforms. Researchers conducting political knowledge experiments or piloting surveys on MTurk should be aware of these differences.
Systematic review of transdermal treatment options in attention-deficit/hyperactivity disorder: implications for use in adult patients
Authors: Correll Christoph U. , Starling Brittney R. , Huss Michael 
Published: April 2021

Abstract

Background
Adults with attention-deficit/hyperactivity disorder (ADHD) often face delays in diagnosis and remain untreated, despite significant negative impacts. To evaluate the safety and efficacy of transdermal treatment options in children, adolescents, and adults, a systematic literature review was conducted, with a focus on the implications of transdermal therapies for ADHD in adults.

Methods
A MEDLINE/Embase/BIOSIS/SCOPUS database search was conducted December 4, 2019, for English-language articles of interventional clinical trials using transdermal formulations for the treatment of ADHD without publication date limit. Assessed outcomes included efficacy, safety, adherence, abuse potential, cost efficacy, and health-related quality of life.

Results
Of 23 eligible publications, 18 were in children or adolescents (n = 1699; range 23-305), and 5 in adults (n = 274; range 14-90); all included methylphenidate transdermal system (MTS). All seven pediatric publications reporting change in ADHD symptomology from baseline reported a significant improvement with MTS treatment. Similarly, in three adult publications, ADHD symptoms improved significantly with MTS treatment. Safety findings in pediatric and adult studies were comparable; the most frequently reported treatment-emergent adverse events (TEAEs), namely, headache, decreased appetite, and insomnia, were reported in 13/16 (81%) of publications reporting specific TEAEs. MTS-related dermal reactions were mostly mild and transient. Discontinuation due to dermal reactions was reported in 10 studies (range 0%-7.1% [1 of 14 patients]). MTS compliance was high when assessed (97%-99%).

Conclusions
Transdermal therapies provide a useful treatment formulation for ADHD. Studies of MTS and other transdermal formulations, such as amphetamine, in adult patients are needed in this underserved population.