bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal anxiety and depression and their associations with mother–child pretend play: a longitudinal observational study
Authors: Rao Zhen , Barker Beth , O’Farrelly Christine , Ramchandani Paul 
Published: May 2021

AbstractBackgroundParental anxiety and depression have been associated with changes to parent–child interactions. Although play constitutes an important part of parent–child interactions and affords critical developmental opportunities, little is known regarding how parental anxiety and depression are related to parent–child play. This is an important knowledge gap because parents play a crucial role in children’s early play experience. The purpose of the current study was to examine whether levels of maternal anxiety and depression respectively predicted frequencies of pretend play in both mothers and their children, and whether mothers’ engagement in pretend play predicted child behaviour problems two years later.MethodsPretend play in 60 mother-toddler dyads (Mage of child = 29.67 months, SD = 3.25,41.7% girls) was assessed during home visits. Maternal anxiety and depression were assessed using self-report questionnaires. Children’s behaviour problems were rated by mothers at baseline and two years later. Hierarchical regression analyses examined concurrent associations between mother–child pretend play and maternal anxiety and depression at baseline, and longitudinal associations between baseline mother pretend play and child behavioural problems two years later.ResultsHigher maternal anxiety predicted less pretend play in mothers and children (β =  − .23, BCa 95% CI: [− .018, − .001]) and β =  − .22, BCa 95% CI [− .014, − .001]). Higher maternal depression predicted less child pretend play (β =  − .20, BCa 95% CI [− .012, − .001]). There was evidence (albeit weak) that more mother pretend play at baseline predicted fewer child behaviour problems two years later (β =  − .18, BCa 95% CI [− 62.38, 11.69]), when baseline child behaviour problems and maternal anxiety were controlled for.ConclusionsMaternal anxiety and depression are associated with less pretend play during mother–child interaction. Mother’s pretend play might help reduce child behavioural problems risks, suggesting that play might be one mechanism by which maternal mental health influences children’s development.
A review of theoretical salt weathering studies for stone heritage
Authors: Oguchi Chiaki T. , Yu Swe 
Published: May 2021

AbstractSalt weathering can cause substantial deterioration of natural rocks, building stones, masonry materials, monuments, and engineering structures. Nearly two centuries of salt weathering studies, both theoretically and empirically, have manifested its power as well as its complexity. This paper attempts to unite the kinds of literature assess the various theories in the light of the combined information. The theoretical approaches concerning the most cited mechanisms of salt weathering such as crystallization, hydration and thermal expansion of crystalline salts are thoroughly reviewed. It is understood that there is no universally acceptable hard and sound theoretical information on this topic yet. More precise theories should be developed to elucidate the complications of the mechanisms of salt weathering as well as to interpret the results of empirical studies.
Performance evaluation of the Q.Clear reconstruction framework versus conventional reconstruction algorithms for quantitative brain PET-MR studies
Authors: Ribeiro Daniela , Hallett William , Tavares Adriana A. S. 
Published: May 2021

Abstract
Background
Q.Clear is a Bayesian penalized likelihood (BPL) reconstruction algorithm that presents improvements in signal-to-noise ratio (SNR) in clinical positron emission tomography (PET) scans. Brain studies in research require a reconstruction that provides a good spatial resolution and accentuates contrast features however, filtered back-projection (FBP) reconstruction is not available on GE SIGNA PET-Magnetic Resonance (PET-MR) and studies have been reconstructed with an ordered subset expectation maximization (OSEM) algorithm. This study aims to propose a strategy to approximate brain PET quantitative outcomes obtained from images reconstructed with Q.Clear versus traditional FBP and OSEM.

Methods
Contrast recovery and background variability were investigated with the National Electrical Manufacturers Association (NEMA) Image Quality (IQ) phantom. Resolution, axial uniformity and SNR were investigated using the Hoffman phantom. Both phantoms were scanned on a Siemens Biograph 6 TruePoint PET-Computed Tomography (CT) and a General Electric SIGNA PET-MR, for FBP, OSEM and Q.Clear. Differences between the metrics obtained with Q.Clear with different β values and FBP obtained on the PET-CT were determined.

Results
For in plane and axial resolution, Q.Clear with low β values presented the best results, whereas for SNR Q.Clear with higher β gave the best results. The uniformity results are greatly impacted by the β value, where β < 600 can yield worse uniformity results compared with the FBP reconstruction.

Conclusion
This study shows that Q.Clear improves contrast recovery and provides better resolution and SNR, in comparison to OSEM, on the PET-MR. When using low β values, Q.Clear can provide similar results to the ones obtained with traditional FBP reconstruction, suggesting it can be used for quantitative brain PET kinetic modelling studies.
Effect of Aegle marmelos on the growth of brushite crystals
Authors: Anushya G. , Mahesh R. , Freeda T. H. , Ramachandran R. , Raju G. 
Published: May 2021

Abstract
Background
The urinary stone formation is a very common health problem due to the prolonged medication. Calcium Hydrogen Phosphate Dihydrate (CaHPO4.2H2O, CHPD and Brushite) is one of the major constituent of urinary stone crystals. The formation and deposition of brushite crystals is the central cause of recurrent kidney stone disease among the global population. The present study aims to investigate the effect of Aegle marmelos leaves on the growth of brushite crystals to explicate the inhibitory effect of urinary stones from a different point of view.

Methods
The CHPD crystals were grown by the Single Diffusion Gel growth technique. In order to inhibit the formation of urinary stones, CHPD crystals are grown in the laboratory in the pure form and by adding the prolonged medicine A. marmelos taken especially by diabetic patients. A comparative study of the pure and A. marmelos leaves added crystals has been carried out using the Growth factor, Powder X-ray diffraction, Microstructural parameters, FTIR and SEM-EDAX.

Results
Total mass of the grown crystals is found to decrease with increasing concentrations of leaf extract of the A. marmelos. On comparing with undoped, crystalline size of the A. marmelos doped samples is reduced. Disappearance of absorption band and peak shift in the FTIR shows the incorporation of functional groups of A. marmelos. The morphology changes of the treated crystals are assessed in SEM.

Conclusions
The result shows that herbal extracts prepared from A. marmelos have good inhibitory effect on the growth of the brushite urinary stone crystals considered.
Safety assessment of the standardized aqueous extract from solid-state cultured Xylaria nigripes (Wuling Shen) in rats
Authors: Lai Ming-Nan , Hsu Hui-Chen , Ng Lean-Teik 
Published: May 2021

Abstract
Background
Xylaria nigripes (Koltz.) Cooke, also known as Wuling Shen, is a high-value medicinal mushroom. It is a herbal medicine traditionally used for treating insomnia, trauma and depression. However, its toxicity has never been systematically evaluated. This study aimed to evaluate the safety of a standardized aqueous extract (XNE), an ingredient of commercial products, prepared from solid-state cultured X. nigripes in rats.

Methods
A 90-day subchronic toxicity study was conducted by oral administration of XNE at daily doses of 20, 1000 and 2000 mg/kg body weight to Sprague-Dawley rats of both sexes, and the control group was given distilled water (vehicle). All animals were checked daily for general behavior, body weight changes and signs of toxicity. At the end of the treatment period, hematological analysis, biochemical analysis and histopathological examination of organs were conducted.

Results
At tested concentrations, oral XNE administration caused no treatment-induced adverse effects on general health, body weight gain, relative organ weights, and hematological and biochemical parameters. Histopathological results also showed no significant structural changes in organs even in high-dose XNE-treated animals.

Conclusion
This study suggests that treatment with XNE for 90 days does not produce significant toxicity, even up to 100 fold (2000 mg/kg body weight/day) of the recommended daily intakes. Therefore, the use of XNE as herbal medicines is considered to be relatively safe.
Perch time allocation and feeding efficiency of flycatching Rhinolophus formosae: an optimal foraging behavior?
Authors: Lee Ya-Fu , Kuo Yen-Min , Chu Wen-Chen , Lin Yu-Hsiu , Chang Hsiang-Yi , Chang Hsing-Yi , Chen Wei-Ming 
Published: May 2021

AbstractBackgroundFlycatching bats are species-rare and comprise predominantly horseshoe bats (Rhinolophidae). Their hang-and-wait foraging mode and long constant-frequency echolocation calls offer advantages in energetics and prey detection, and may enable them apt to foraging optimally, yet not much is known about the foraging behavior of flycatching bats. Thus we assessed the perch use and foraging performance in the field by one of the largest horseshoe bats,Rhinolophus formosae, and offered insights on their perch time allocation.ResultsThe perching-foraging behaviors of the bats did not differ significantly between forest settings, but the residence and giving-up time, mean attack, and attack rate were higher in the late spring-early summer, whereas the mean capture, capture rate, and attack efficiency were lower in the late summer when volant juveniles joined the nocturnal activity. The bats maintained flycatching and exhibited largely similar attack rates through the night with peak residence time around the midnight, but the capture rate and attack efficiency both reduced toward midnight and then increased toward the hours right before dawn. The attack rate was negatively correlated to the number of perches used and perch switch; by contrast, the capture rate was positively correlated with both factors. The total residence time at a site increased but mean residence time per perch decreased as the number of perches used and perch-switch increased. The giving-up time was inversely correlated to the attack rate and attack efficiency, and decreased with an increasing capture rate.ConclusionsThe bats increased perch switch at lower attack rates in early spring, but switched less frequently in late spring and prime summer months when insect abundance is higher. By scanning through a broad angular range for prey detection, and switching more frequently among perches,R. formosaeforaged with an increased capture rate, and were able to remain at the site longer by slightly reducing their mean residence time per perch. Our results concur with the predictions of optimal foraging theory for patch selection and offer implications for further exploration of the foraging behavior of flycatching horseshoe bats.
Dying in honour: experiences of end-of-life palliative care during the 2013–2016 Ebola outbreak in Guinea
Authors: Nouvet Elysée , Bezanson Kevin , Hunt Matthew , Kouyaté Sekou , Schwartz Lisa , Diallo Fatoumata Binta , de Laat Sonya , Bah-Sow Oumou Younoussa , Diallo Alpha Ahmadou , Diallo Pathé 
Published: May 2021

AbstractWith no cure and a high mortality rate, Ebola virus disease (EVD) outbreaks require preparedness for the provision of end-of-life palliative care. This qualitative study is part of a larger project on palliative care in humanitarian contexts. Its goal was to document and deepen understanding of experiences and expectations related to end-of-life palliative care for patients infected with Ebola virus disease (EVD) in West African Ebola treatment centres (ETCs) during the 2013–2016 epidemic. It consisted of 15 in-depth semi-structured interviews with individuals impacted by EVD in a Guinean ETC: either as patients in an ETC, healthcare providers, healthcare providers who were also EVD patients at one point, family relations who visited patients who died in an ETC, or providers of spiritual support to patients and family. Analysis was team based and applied an interpretive descriptive approach. Healthcare delivery in humanitarian emergencies must remain respectful of patient preferences but also local and contextual values and norms. Of key importance in the Guinean context is the culturally valued experience of “dying in honour”. This involves accompaniment to facilitate a peaceful death, the possibility of passing on final messages to family members, prayer, and particular practices to enact respect for the bodies of the deceased. Participants emphasized several challenges to such death in Ebola treatment centres (ETCs), as well as practices they deemed helpful to alleviating dying patients’ suffering. An overarching message in participants’ accounts was that ideally more would have been done for the dying in ETCs. Building on participants’ accounts, we outline a number of considerations for optimizing end-of-life palliative care during current and future public health emergencies, including for COVID-19.
Investigation of clinically acceptable agreement between two methods of automatic measurement of limb occlusion pressure: a randomised trial
Authors: Hughes Luke , McEwen James 
Published: May 2021

Abstract
Background
Development of automatic, pneumatic tourniquet technology and use of personalised tourniquet pressures has improved the safety and accuracy of surgical tourniquet systems. Personalisation of tourniquet pressure requires accurate measurement of limb occlusion pressure (LOP), which can be measured automatically through two different methods. The ‘embedded LOP’ method measures LOP using a dual-purpose tourniquet cuff acting as both patient sensor and pneumatic effector. The ‘distal LOP’ method measures LOP using a distal sensor applied to the patient’s finger or toe of the operating limb, using photoplethysmography to detect volumetric changes in peripheral blood circulation. The distal LOP method has been used clinically for many years; the embedded LOP method was developed recently with several advantages over the distal LOP method. While both methods have clinically acceptable accuracy in comparison to LOP measured using the manual Doppler ultrasound method, these two automatic methods have not been directly compared. The purpose of this study is to investigate if the embedded and distal methods of LOP measurement have clinically acceptable agreement. The differences in pairs of LOP measurement in the upper and lower limbs of 81 healthy individuals were compared using modified Bland and Altman analysis. In surgery, it is common for cuff pressure to deviate from the pressure setpoint due to limb manipulation. Surgical tourniquet systems utilise a ± 15 mmHg pressure alarm window, whereby if the cuff pressure deviates from the pressure setpoint by > 15 mmHg, an audiovisual alarm is triggered. Therefore, if the difference (bias) ± SE, 95% CI of the bias and SD of differences ± SE in LOP measurement between the embedded and distal methods were all within ±15 mmHg, this would demonstrate that the two methods have clinically acceptable agreement.

Results
LOP measurement using the embedded LOP method was − 0.81 ± 0.75 mmHg (bias ± standard error) lower than the distal LOP method. The 95% confidence interval of the bias was − 2.29 to 0.66 mmHg. The standard deviation of the differences ± standard error was 10.35 ± 0.49 mmHg. These results show that the embedded and distal methods of LOP measurement demonstrate clinically acceptable agreement.

Conclusions
The findings of this study demonstrate clinically acceptable agreement between the embedded and distal methods of LOP measurement. The findings support the use of the embedded LOP method of automatic LOP measurement using dual-purpose tourniquet cuffs to enable accurate, effective and simple prescription of personalised tourniquet cuff pressures in a clinical setting.
MAP, Johne’s disease and the microbiome; current knowledge and future considerations
Authors: Matthews Chloe , Cotter Paul D. , O’ Mahony Jim 
Published: May 2021

AbstractMycobacterium avium subsp. paratuberculosis is the causative agent of Johne’s disease in ruminants. As an infectious disease that causes reduced milk yields, effects fertility and, eventually, the loss of the animal, it is a huge financial burden for associated industries. Efforts to control MAP infection and Johne’s disease are complicated due to difficulties of diagnosis in the early stages of infection and challenges relating to the specificity and sensitivity of current testing methods. The methods that are available contribute to widely used test and cull strategies, vaccination programmes also in place in some countries. Next generation sequencing technologies have opened up new avenues for the discovery of novel biomarkers for disease prediction within MAP genomes and within ruminant microbiomes. Controlling Johne’s disease in herds can lead to improved animal health and welfare, in turn leading to increased productivity. With current climate change bills, such as the European Green Deal, targeting livestock production systems for more sustainable practices, managing animal health is now more important than ever before. This review provides an overview of the current knowledge on genomics and detection of MAP as it pertains to Johne’s disease.
Coblation cryptolysis for treatment of tonsillar stones: a randomized clinical study
Authors: Elsayad Osama A. , Hussein Mohammed S. 
Published: May 2021

AbstractBackgroundTonsillectomy is usually indicated in patients with tonsillar stones. It is thought coblation cryptolysis avoids the hazards related to monopolar bipolar diathermy and the regular cold surgical technique. This study compared the peri-operative outcomes in patients with tonsillar stones submitted to coblation cryptolysis, monopolar bipolar dissection, and cold dissection techniques. This randomized study included 105 patients with tonsillar stones. The included patients comprised three groups: GI (n= 35) was subjected to cold dissection, GII (n= 35) was subjected to monopolar bipolar diathermy tonsillectomy, and GIII (n= 35) was subjected to coblation cryptolysis. Outcome parameters included operative time, intraoperative bleeding, consumption of postoperative analgesia, and time to normal food intake.ResultsGIII patients experienced significantly shorter operative time, less intraoperative bleeding, less consumption of postoperative analgesics, and less time to normal diet when compared with the other two groups.ConclusionCoblation cryptolysis is a safe and effective technique in the management of tonsillar stones. It appears to be superior to other surgical interventions.
Bending of light in novel 4D Gauss-Bonnet-de Sitter black holes by the Rindler-Ishak method
Authors: Heydari-Fard Mohaddese , Heydari-Fard Malihe , Reza Sepangi Hamid 
Published: May 2021

Abstract
We study the bending of light in the space-time of black holes in the four-dimensional Einstein-Gauss-Bonnet theory of gravity, recently proposed by Glavan and Lin in Phys. Rev. Lett., 124 (2020) 081301. Using the Rindler-Ishak method, the effect of Gauss-Bonnet coupling on the bending angle is studied. We show that a positive Gauss-Bonnet coupling gives a negative contribution to the Schwarzschild-de Sitter deflection angle, as one would expect.
Kinetic phase diagram for a binary system near the transition to diffusionless solidification
Authors: Buchbinder G. L. 
Published: May 2021

Abstract
The rapid solidification of a binary mixture in the region of the interface velocities V close to the diffusion speed in the bulk of the liquid phase V

D
is considered within the framework of the local nonequilibrium approach. In this high-speed region the derivation of the analytical expression for the “temperature-velocity” response function representing kinetic phase diagram is given without using the concept of the equilibrium phase diagram. The modes of movement of the interface both without and with the drag effect are analyzed. It is shown that the drag effect can be accompanied by a local interface temperature maximum at

.
Use of a mutation-specific genotyping method to assess for HIV-1 drug resistance in antiretroviral-naïve HIV-1 Subtype C-infected patients in Botswana
Authors: Maruapula Dorcas , MacLeod Iain J. , Moyo Sikhulile , Musonda Rosemary , Seatla Kaelo , Molebatsi Kesaobaka , Leteane Melvin , Essex Max , Gaseitsiwe Simani , Rowley Christopher F. 
Published: May 2021

Background:HIV-1 drug resistance poses a major threat to the success of antiretroviral therapy. The high costs of available HIV drug resistance assays prohibit their routine usage in resource-limited settings. Pan-degenerate amplification and adaptation (PANDAA), a focused genotyping approach based on quantitative PCR (qPCR), promises a fast and cost-effective way to detect HIV drug resistance mutations (HIVDRMs). Given the high cost of current genotyping methods, we sought to use PANDAA for screening key HIVDRMs in antiretroviral-naïve individuals at codons 103, 106 and 184 of the HIV-1 reverse transcriptase gene. Mutations selected at these positions have been shown to be the most common driver mutations in treatment failure. Methods:A total of 103 samples from antiretroviral-naïve individuals previously genotyped by Sanger population sequencing were used to assess and verify the performance of PANDAA. PANDAA samples were run on the ABI 7500 Sequence Detection System to genotype the K103N, V106M and M184V HIVDRMs. In addition, the cost per sample and reaction times were compared.Results:Sanger population sequencing and PANDAA detected K103N mutation in three (2.9%) out of 103 participants. There was no evidence of baseline V106M and M184V mutations observed in our study. To genotype the six HIVDRMs it costs approximately 40 USD using PANDAA, while the reagents cost per test for Sanger population sequencing is approximately 100 USD per sample. PANDAA was performed quicker compared to Sanger sequencing, 2 hours for PANDAA versus 15 hours for Sanger sequencing.Conclusion:The performance of PANDAA and Sanger population sequencing demonstrated complete concordance. PANDAA could improve patient management by providing quick and relatively cheap access to drug-resistance information.