bluuebunny/crossref_metadata_2025_split huggingface dataset:
HIV in kidney transplantation
Authors: Glicklich Daniel , Nog Rajat 
Published: December 2021

Purpose of review
The aim of this study was to describe recent developments in renal transplantation for HIV-positive recipients, especially the HIV Organ Policy Equity (HOPE) trial results.

Recent findings
HOPE trial data show that HIV-positive D+/R+ results are excellent and similar to D−/R+ in patients controlled on antiretroviral therapy (ART). Patients coinfected with hepatitis C or B virus now have effective treatment available. As pretransplant evaluation and post-transplant management is more complex in HIV-positive individuals early referral is important and coordination of evaluation and care with an infectious disease specialist is critical. HIV coordinated care services should be involved for best outcomes. HIV-positive renal transplant recipients have an increased risk of rejection and evidence suggests that standard lymphocyte depletion induction and maintenance immunosuppression be employed. Cardiovascular risk reduction and surveillance and attention to metabolic bone disease are important for HIV-positive renal transplant recipients.

Summary
HIV-positive to HIV-positive renal transplantation has been established as well tolerated and successful. Further efforts are needed to expand access to transplantation in this population.

Video abstract

http://links.lww.com/MOT/A29.
Health-Related Social Needs Facing Youth With Nonalcoholic Fatty Liver Disease
Authors: Orkin Sarah , Yodoshi Toshifumi , Sun Qin , Fei Lin , Meryum Syeda , Ley Sanita , Arce-Clachar Ana Catalina , Bramlage Kristin , Xanthakos Stavra , Kahn Robert , Beck Andrew F. , Mouzaki Marialena 
Published: December 2021

Background:
The objective of this study was to identify the prevalence of health-related social needs among youth with nonalcoholic fatty liver disease.

Methods:
Retrospective review of prospectively administered health-related social needs questionnaires from Steatohepatitis Clinics.

Results:
Patients with nonalcoholic fatty liver disease (n = 271) were predominantly male (72%) and non-Hispanic (68%). The most common unmet need was food insecurity (13%, n = 36). Families who endorsed food insecurity at the first visit were 27-fold more likely to have unmet health-related social needs persist at subsequent visits than those who were food secure at their first visit (95% confidence interval, 6.7-111).

Conclusions:
Screening for social, economic, and environmental needs may identify previously unrecognized family challenges and may enhance intervention delivery, inform resource allocation, and improve outcomes.
Nutritional Management of Children With Neurological Impairment in China: Current Status and Future Directions
Authors: Hong Li , Xu Kaishou , Zhu Dengna , Sun Lingxia , Dipasquale Valeria , Romano Claudio 
Published: December 2021

Objectives:
The aim of this study is to assess the awareness of Chinese physicians on gastrointestinal and nutritional management of children with neurological impairment (NI) and to assess the practical application of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition guidelines on the management of nutritional and gastrointestinal problems in children with NI in Asian countries, particularly in several major medical centers in China.

Methods:
A web-based questionnaire was distributed between November 2020 and January 2021 among Chinese healthcare professionals involved in the clinical management of children with NI. Fifteen questions covering the most relevant aspects of nutritional management and gastrointestinal issues of children with NI were surveyed. A descriptive analysis of responses was performed.

Results:
A total of 577 healthcare professionals from over 28 provinces in China answered the questionnaire. Anthropometrics were the most used parameters (n = 539) to assess nutritional status. Most respondents (n = 455) indicated weight faltering and/or failure to thrive as definition of undernutrition. Direct observation of meals was considered the recommended method for diagnosing oropharyngeal dysfunction by 542 professionals. Fundoplication was indicated at the time of gastrostomy placement in patients with uncontrolled gastroesophageal reflux disease by 437 respondents.

Conclusions:
The clinical practice of Chinese healthcare professionals does not completely match the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition guidelines, probably due to the medical system and the economic, social, and cultural differences. Further studies are needed to improve clinical practice and knowledge. Multidisciplinary approach is crucial to optimize the overall medical care and quality of life for children with NI.
Humoral and cellular responses to SARS-CoV-2 vaccination in patients with lymphoid malignancies
Authors: Lim Sean H. , Campbell Nicola , Stuart Beth , Johnson Marina , Joseph-Pietras Debora , Kelly Adam , Jeffrey Danielle , Turaj Anna H. , Rolfvondenbaumen Kate , Galloway Celine , Wynn Thomas , Coleman Adam R. , Ward Benjamin , Long Karen , Bates Andrew T. , Ayres Diana , Lown Robert , Falconer Janlyn , Brake Oliver , Batchelor James , Willimott Victoria , Al-Naeeb Anna Bowzyk , Robinson Lisa , O’Callaghan Ann , Collins Graham P. , Menne Tobias , Faust Saul N. , Fox Christopher P. , Ahearne Matthew , Johnson Peter W.M. , Davies Andrew J. , Goldblatt David 
Published: December 2021

SUMMARYSARS-CoV-2 vaccination protects against COVID-19. Antibodies and antigen-specific T-cell responses against the spike domain can be used to measure vaccine immune response. Individuals with lymphoma have defects in humoral and cellular immunity that may compromise vaccine response. In this prospective observational study of 457 participants with lymphoma, 52% of participants vaccinated on treatment had undetectable anti-spike IgG antibodies compared to 9% who were not on treatment. Marked impairment was observed in those receiving anti- CD20 antibody within 12 months where 60% had undetectable antibodies compared to 11% on chemotherapy, which persisted despite three vaccine doses. Overall, 63% had positive T-cell responses irrespective of treatment. Individuals with indolent B-cell lymphoma have impaired antibody and cellular responses that were independent of treatment. The significant reduction and heterogeneity in immune responses in these individuals emphasise the urgent need for immune response monitoring and alternative prophylactic strategies to protect against COVID- 19.
Modeling COVID-19 Aerosol Transmission in Primary Schools
Authors: Swanson Tessa , Guikema Seth , Bagian James , Payne Claire 
Published: December 2021

AbstractSchools must balance public health, education, and social risks associated with returning to in-person learning. These risks are compounded by the ongoing uncertainty about vaccine availability and uptake for children under 12 years of age. In this paper, we show how the risk of infections that result directly from in-class aerosol transmission within an elementary school population can be estimated in order to compare the effects of different countermeasures. We compare the effectiveness of these countermeasures in reducing transmission including required masking at three levels of mask effectiveness, improving room airflow exchange rates, weekly testing of the students, and lunch partitioning. Our results show that multiple layers of interventions are necessary to keep in-class infections relatively low. These results can inform school administrators about how these interventions can help manage COVID-19 spread within their own elementary school populations.
Kinetic characteristics of transcriptional bursting in a complex gene model with cyclic promoter structure
Authors: Yang Xiyan , Wang Zihao , Wu Yahao , Zhou Tianshou , Zhang Jiajun 
Published: December 2021

AbstractWhile transcription occurs often in a bursty manner, various possible regulations can lead to complex promoter patterns such as promoter cycles, giving rise to an important issue: How do promoter kinetics shape transcriptional bursting kinetics? Here we introduce and analyze a general model of the promoter cycle consisting of multi-OFF states and multi-ON states, focusing on the effects of multi-ON mechanisms on transcriptional bursting kinetics. The derived analytical results indicate that bust size follows a mixed geometric distribution rather than a single geometric distribution assumed in previous studies, and ON and OFF times obey their own mixed exponential distributions. In addition, we find that the multi-ON mechanism can lead to bimodal burst-size distribution, antagonistic timing of ON and OFF, and diverse burst frequencies, each further contributing to cell-to-cell variability in the mRNA expression level. These results not only reveal essential features of transcriptional bursting kinetics patterns shaped by multi-state mechanisms but also can be used to the inferences of transcriptional bursting kinetics and promoter structure based on experimental data.
Deficiency in endocannabinoid synthase DAGLB contributes to Parkinson’s disease and dopaminergic neuron dysfunction
Authors: Liu Zhenhua , Yang Nannan , Dong Jie , Tian Wotu , Chang Lisa , Ma Jinghong , Guo Jifeng , Tan Jieqiong , Dong Ao , He Kaikai , Zhou Jingheng , Cinar Resat , Wu Junbing , Salinas Armando , Sun Lixin , Kung Justin , Xie Chengsong , Oldham Braden , Kumar Mantosh , Hawes Sarah , Ding Jinhui , Wang Lupeng , Wang Tao , Chan Piu , Zhang Zhuohua , Le Weidong , Chen Shengdi , Lovinger David M. , Cui Guohong , Li Yulong , Cai Huaibin , Tang Beisha 
Published: December 2021

Abstract2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid (eCB) in the brain, regulates diverse neural functions. However, whether 2-AG deficiency contributes to Parkinson’s disease (PD) and nigral dopaminergic neurons (DANs) dysfunction is unclear. Diacylglycerol lipase α and β (DAGLA and DAGLB) mediate the biosynthesis of 2-AG. Using homozygosity mapping and whole-exome sequencing, we linked multiple homozygous loss-of-function mutations in DAGLB to a form of early-onset autosomal recessive PD. We then used RNA sequencing and fiber photometry with genetically encoded eCB sensors to demonstrate that DAGLB is the main 2-AG synthase in nigral DANs. Genetic knockdown of Daglb by CRISPR/Cas9 in mouse nigral DANs substantially reduces 2-AG levels in the substantia nigra (SN). The SN 2-AG levels are markedly correlated with the vigor of movement during the acquisition of motor skills, while Daglb-deficiency impairs motor learning. Conversely, pharmacological enhancement of 2-AG levels increases nigral DAN activity and dopamine release and improves motor learning. Together, we demonstrate that DAGLB-deficiency contributes to the etiopathogenesis of PD, reveal the importance of DAGLB-mediated 2-AG biosynthesis in nigral DANs in regulating neural activity and dopamine release, and provide preclinical evidence for the beneficial effects of 2-AG augmentation in PD treatment.
miR-124 regulates Notch and NeuroD1 and to mediate transition states of neuronal development
Authors: Konrad Kalin D. , Song Jia L. 
Published: December 2021

AbstractMicroRNAs (miRNAs) regulate gene expression by destabilizing target mRNA and/or inhibiting translation in animal cells. The ability to mechanistically dissect the function of miR-124 during specification, differentiation, and maturation of neurons during development within a single system has not been accomplished. Using the sea urchin (Strongylocentrotus purpuratus) embryo, we take advantage of the manipulability of the embryo and its well-documented gene regulatory networks (GRNs). We incorporated NeuroD1 as part of the sea urchin neuronal GRN and determined that miR-124 inhibition resulted in decreased gut contractions, swimming velocity, and neuronal development. We further integrated post-transcriptional regulation of miR-124 into the neuronal GRN. Inhibition of miR-124 resulted in increased number of cells expressing transcription factors associated with progenitor neurons and a concurrent decrease of mature and functional neurons. Results revealed that miR-124 regulates undefined factors early in neurogenesis during neuronal specification and differentiation in the early blastula and gastrula stages. In the late gastrula and larval stages, miR-124 regulates Notch and NeuroD1. Specifically, miR-124 regulates the transition between neuronal differentiation and maturation, by directly suppressing NeuroD1. Removal of miR-124’s suppression of NeuroD1 results in increased mature neurons with decreased Synaptagmin B-positive mature, functional neurons. By removing both miR-124 suppression of NeuroD1 and Notch, we were able to phenocopy miR-124 inhibitor induced defects. Overall, we have improved the neuronal GRN and identified miR-124 to play a prolific role in regulating various transitions of neuronal development.
Control method of spray curing system for cement concrete members based on the AdaBoost.M1 algorithm
Authors: Yuan Wei , Yang Renfeng , Yu Jianyou , Zeng Qunrong , Yao Zechen 
Published: December 2021

Purpose
Spray curing has become the preferred curing method for most cement concrete members because of its lower cost and sound effect. However, the spray curing quality of members is vulnerable to random variation environment factors and anthropogenic interferences. This paper aims to introduce the machine learning algorithm into the spray curing system to optimize its control method to improve the spray curing quality of members.

Design/methodology/approach
The critical parameters affecting the spray curing quality of members were collected through experiments, such as the temperature and humidity of the member's surface, the temperature, humidity and wind speed of the environment. The C4.5 algorithm was used as a weak classifier algorithm, and the AdaBoost.M1 algorithm was used to cascade multiple weak classifiers to form a robust classifier according to the collected data.

Findings
The results showed that the model constructed by the AdaBoost.M1 algorithm had achieved higher accuracy and robustness among the two algorithms. Based on the classification model built by the AdaBoost.M1 algorithm, the spray curing system can cause automatic decision-making spray switching according to the member's real-time curing state and environment.

Originality/value
With the classification model constructed by the AdaBoost.M1 algorithm, the spray curing system can overcome the disadvantages that external factors greatly influence the current control method of the spray curing system, and the intelligent control of the spray curing system was realized to a certain extent. This paper provides a reference for applying machine learning algorithms in the intellectual transformation of bridge construction equipment.
Measuring personal and academic differences in students’ perceived social media credibility
Authors: Bashir Iqra , Malik Amara , Mahmood Khalid 
Published: December 2021

Purpose
Social media is a popular source for information sharing in the contemporary world. Social media allow individuals to create, publish and diffuse contents directly. This openness has increased the risk of running into misinformation and raised questions about credibility of information shared. This study aims to examine the credibility of social media through the perceptions of university students. It also intends to see the difference in opinions based on their gender, academic disciplines and programs of study.

Design/methodology/approach
The study was based on a cross-sectional survey; a structured questionnaire was developed by consulting the relevant literature. Students were selected on convenient basis from all the programs of four universities of Faisalabad, Pakistan. Four hundred students were selected randomly from each university.

Findings
The findings indicated that students considered social media partially credible. Currency, community wellness, understandability and completeness of information were the highly rated facets, while factual and unbiased information was the low rated aspects. The perceived credibility of social media among the university students was the same across genders, programs of study and academic disciplines.

Research limitations/implications
The study may be helpful for social media service providers to address the concerns that students had in their perception regarding its credibility.

Originality/value
This study may likely benefit faculty members, researchers, librarians/information professionals and digital libraries to understand the students’ concerns about social media credibility from a developing country’s perspective. Such understanding will enable them to better address, educate and train university students at how to evaluate the quality of information on social media by offering information literacy programs. It is direly needed that university libraries should train the students to be proficient in assessing the quality of information by offering information or digital literacy programs. Moreover, the study may be helpful for social media service providers to address the concerns that students had in their perception regarding its credibility.
Customer reciprocity in greening: the role of service quality
Authors: Basu Debarati , Chakraborty Kamalika , Mitra Shabana , Verma Nishant Kumar 
Published: December 2021

Purpose
Firms are increasingly making customers key stakeholders in their greening processes, requiring them to voluntarily use their resources to benefit the firm. In this context, this paper develops a new construct – tangible customer citizenship behaviour (CCB), i.e. voluntary participation of customer in operational processes of the company beyond normal requirements of exchange. This requires more involvement than the already documented intangible CCB. The purpose of the paper is to then explore whether service quality (SQ) (online and offline) influences such voluntary customer reciprocity in greening.

Design/methodology/approach
This study used a virtual survey among 400 customers of e-commerce firms that have adopted greening practices requiring customer engagement and regressions were used to test the hypotheses.

Findings
The authors find that both online and offline SQ positively impact intangible CCB but have no impact on customer greening reciprocity (tangible CCB). Additionally, the authors find that offline SQ positively impacts customer greening awareness. However, in spite of the presence of greening awareness and display of intangible CCB, SQ does not have any impact on greening reciprocity.

Originality/value
This study introduces to literature a more tangible form of voluntary behaviour on the part of the customer, i.e. tangible CCB or reciprocity. To the best of the authors’ knowledge, it is also one of the first to study the customer as an important stakeholder and participant in a business-to-consumer firm’s operating processes, particularly in greening which has no direct impact on the firm’s core offering. The focus on greening in the Indian context is also novel given the greening costs and requirements and the price competition are very different in emerging market contexts where e-commerce firms are experiencing the maximum growth.
Building an ethical culture by improving conditions for whistleblowing
Authors: Smaili Nadia 
Published: December 2021

Purpose
This paper aims to discuss the importance of an effective internal whistleblowing system in building a more ethical organizational climate.

Design/methodology/approach
This study draws on the literature to make recommendations for organizations, managers and boards of directors regarding implementing an effective whistleblowing process.

Findings
This paper offers practical information on what constitutes an appropriate level of preparedness and responsiveness. Organizations can reinforce their internal ethics by encouraging whistleblowers to report complaints internally. An effective whistleblowing process depends on the organization’s desire to build an ethical climate and its awareness of the power of whistleblowing as an ethical tool.

Originality/value
This study will help managers and other professionals to create and maintain an ethical climate by implementing an effective whistleblowing process. The discussion in this paper is important for any type of organization concerned with empowering whistleblowers and the whistleblowing process.
The incidence of accounting fraud is increasing: is it a matter of the gender of chief financial officers?
Authors: Wahyuningtyas Endah Tri , Aisyaturrahmi Aisyaturrahmi 
Published: December 2021

PurposeThe purpose of this paper is to examine the association between accounting fraud and the gender of chief financial officers (CFOs).Design/methodology/approachThis study uses a sample of US-listed firms for the period from 2000 to 2010. This paper takes this distribution of the sample observations because firms sanctioned by the Securities and Exchange Commission as reported in Accounting and Auditing Enforcement Releases for fraud are more heavily weighted in the 2000 to 2010 period.FindingsThis study provides considerable evidence to suggest that firms with female CFOs are negatively associated with accounting fraud. The study also suggests that in state-owned enterprises, in which political concerns are likely to be more pronounced, the relationship between female CFOs and accounting fraud is negatively less significant. This study conducts an additional test about when and why boards’ diversity reduces accounting fraud or concerns. The result shows that the structure of gender-mixed boards is better than male-only boards. Therefore, it is important to control the activities or decisions of powerful chief executive officers.Research limitations/implicationsIn general, the findings contribute to the current discussion on the necessity of increasing gender diversity as a corporate governance mechanism. This study is specifically focussed on CFOs that may directly have important implications for financial reporting and corporate governance.Originality/valueThis paper extends prior research by addressing the potential effects of female CFOs on accounting fraud. For example, Zhouet al.(2018) examine the relationship between executive compensation and the incidence of corporate fraud in Chinese listed companies from the perspective of delisting pressure. The result documents that there is no a relationship between CFO gender and accounting fraud. The results, however, find that female CFOs are negatively associated with accounting fraud; meaning that the presence of female CFOs brings positive implications for financial reporting and corporate governance.