bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disclosing the Bioactive Metabolites Involved in the in Vitro Anthelmintic Effects of Mediterranean Salt-Tolerant Plants: A Combined Approach Using PVPP and HPLC-ESI-MSn
Authors: Oliveira Marta , Lima Caroline Sprengel , Setha Ketavong , Llorent-Martínez Eulogio J. , Hoste Hervé , Custódio Luísa 
Published: September 2021

Abstract
Strategies to reduce dependence on synthetic drugs for the treatment of gastrointestinal nematodes (GIN) infections in ruminants include the search for novel anthelmintic scaffolds on plants, yet salt tolerant plants remain overlooked. The aims of this study are to evaluate the in vitro anthelmintic properties of selected salt-tolerant plants against GIN, and identify the potential bioactive secondary metabolites involved. For that purpose, 80% acetone/water extracts were prepared from dried biomass of aerial organs of nine salt tolerant plant species and tested against Haemonchus contortus and Trichostrongylus colubriformis by the Larval Exsheathment Inhibition Assay (LEIA) and Egg Hatching Inhibition Assay (EHIA). Pistacia lentiscus, Limoniatrum monopetalum, Cladium mariscus and Helychrisum italicum picardi were the most active in both GIN and life stages. To investigate the role of polyphenols in the anthelmintic activity, four selected extracts were treated with PVPP, and non-treated and treated samples were further characterized by high-performance liquid chromatography with electrospray ionization mass spectrometric detection (HPLC-ESI-MSn). While polyphenols seem responsible for the EHIA properties, they are partially accountable to LEIA results. Several phenolics involved in the anthelmintic effects were identified and discussed. In sum, these species are rich sources of anthelmintic compounds and, therefore, are of major interest for nutraceutical and/or phytotherapeutic applications against GIN in ruminants.
Governance Tensions in the Healthcare Sector: A Contrasting Case Study in France
Authors: Mériade Laurent , Rochette Corinne 
Published: September 2021

Abstract
Background: Political and managerial reforms affect the health sector by translating into governance tensions. As identified in the public management literature, they come from the diffusion of management principles and practices from the business world. They manifest at four levels: institutional, organisational, managerial and instrumental. The objective of this research is to understand how these tensions express healthcare institutions with different status. Methods: We conduct a contrasting case study exploring the cases of two French healthcare institutions, one private for-profit (clinic) and one public not-for-profit (cancer treatment centre). Our analyses are mainly based on the content analysis of 32 semi-structured interviews conducted with staff (nurses, doctors, management and administrative staff) of these two institutions.Results: Our results show that these tensions can be distinguished into three categories (tensions on professional values, standards and practices) which are expressed differently depending on the type of healthcare institution and its main management characteristics.Conclusions: Unexpectedly, in the for-profit institution, the most intense tensions concern professional standards, whereas they concern professional practices in the not-for-profit institution. These analyses can help guide policy makers and health care managers to better integrate these tensions into their political and managerial decisions.
Stabilization of ZnO Nanoparticles Using Water Extract of Waste Coconut Husk and Photocatalytic Activity
Authors: Baglari Sanjib , Brahma Dulu , Gautam Ujjal K , Kalita Pranjal , Baruah Manasi Buzar 
Published: September 2021

Abstract
Here, we report the synthesis of highly photoactive zinc oxide nanoparticles using water extract of waste coconut husk ash as a precipitating agent in a green approach which is a potential source of natural alkaline media. The formation of zinc oxide nanoparticles at different pH of the solution of coconut husk ash was confirmed through powder XRD, SEM-EDX, UV-Vis, FTIR and photoluminescence spectroscopy. The photocatalytic performance of the samples was evaluated through the degradation of methylene blue (MB)and methyl orange (MO) under solar irradiation which undergoes degradation around 98% and 56% within 120 min, respectively. The high photocatalytic activity and rate constant could be attributed to the large surface area due to small particle size that could provide quicker photon absorption and reduction of charge carrier recombination. This current work introduces a new method to reduce energy consumption for the synthesis of highly photoactive low-cost zinc oxide nanoparticles.
Trends Over Two Decades in Life Expectancy With Complex Health Problems Among Older Swedes: Implications for The Provision of Integrated Medical and Social Care
Authors: Meinow Bettina , Li Peng , Jasilionis Domantas , Oksuzyan Anna , Sundberg Louise , Kelfve Susanne , Wastesson Jonas W 
Published: September 2021

Abstract
Background

Due to population aging, it is essential to examine to what extent rises in life expectancy (LE) consist of healthy or unhealthy years. Most health expectancy studies have been based on single health measures and have shown divergent trends. We used a multi-domain indicator, complex health problems (CHP), indicative of the need for integrated medical and social care, to investigate how LE with and without CHP developed in Sweden between 1992 and 2011. We also addressed whether individuals with CHP more commonly lived in the community in 2011 compared to earlier years.
Methods

CHP were defined as having severe problems in at least two of three health domains related to the need for medical and/or social care: symptoms/diseases, cognition/communication, and mobility. The Swedish Panel Study of Living Conditions of the Oldest Old (SWEOLD), a nationally representative survey of the Swedish population aged ≥ 77 years with waves in 1992, 2002 and 2011 (n ≈ 2000), was used to estimate the prevalence of CHP. Age- and gender-specific death rates were obtained from the Human Mortality Database. The Sullivan method was deployed to calculate the remaining life expectancy with and without CHP. The estimates were decomposed to calculate the contribution of changes from morbidity and mortality to the overall trends in LE without CHP.
Results

Between 1992 and 2011, both total LE (+ 1.69 years [95% CI 1.56;1.83] and LE without CHP (+ 0.84 years [-0,87;2.55]) at age 77 increased for men, whereas LE at age 77 increased for women (+ 1.33 [1.21;1.47]) but not LE without CHP (-0.06 years [-1.39;1.26]). When decomposing the trend, we found that the increase in LE with CHP was mainly driven by an increase in the prevalence of CHP. Among individuals with CHP the proportion residing in residential care was lower in 2011 (37%) compared to 2002 (58%) and 1992 (53%).
Flupyradifurone Induces Transgenerational Hormesis Effects in the Cowpea Aphid, Aphis Craccivora (Koch)
Authors: Fouad Eman , El-Sherif Sherifa A.N. , Mokbel El-Sayed M. S. 
Published: September 2021

Abstract
Insecticide induced-hormesis, a biphasic phenomenon ,with low-dose stimulation and high-dose inhibition, which effectively contributes to pest resurgence. Although cowpea aphid, Aphis craccivora (Koch) (Homoptera: Aphididae), is the most infection insect to legume crops in Egypt, its’ hormesis to flupyradifurone did not previously establish. Therefore, age-stage two-sex life analysis was used to investigate the sublethal and transgenerational effects of flupyradifurone on two successive generations of A. craccivora. Leaf-dip bioassay method revealed high toxicity of flupyradifurone against A. craccivora with LC50 value of 1.82 mg L-1 after 48 h exposure. Treatment of parent generation (F0) with LC10 and LC25 of flupyradifurone significantly increased the longevity and fecundity of the directly exposed adults. The results of transgenerational effects showed that treatment of (F0) with LC25 induced a significant hormetic effects in progeny generation (F1). Furthermore, flupyradifurone at LC25 significantly enhanced the biological traits such as intrinsic rate of increase (r), finite rate of increase (λ) and net reproductive rate (R0) compared with the control. Similarly, both LC10 and LC25 caused a significant increase in the mean generation time T (d). Conversely ,both treatments had a significant decrease in the doubling time (DT). In conclusion, the obtained data demonstrate that exposure of (F0) to flupyradifurone at LC10 and LC25 enhanced longevity and fecundity in of the directly exposed adults of A. craccivora and induced transgenerational hormesis across the subsequent (F1) generation. These grades must be taken into consideration when using flupyradifurone against cowpea aphids.
State and trait anxiety related gamma oscillations in patients with anxiety within the Research Domain Criteria (RDoC) framework
Authors: Kim Kyoung Min , Bong Su Hyun , Kim Jun Won 
Published: September 2021

Abstract
Background

Diagnosis of anxiety has relied primarily on self-report. This study examined using quantitative electroencephalography (qEEG) to assess the association between anxiety and underlying neural correlates.
Methods

A total of 41 participants who visited a psychiatric clinic underwent resting state EEG and completed the State-Trait Anxiety Inventory. The absolute power of six frequency bands were analyzed: delta (1–4 Hz), theta (4–8 Hz), alpha (8–10 Hz), fast alpha (10–13.5 Hz), beta (13.5–30 Hz), and gamma (30–80 Hz).
Results

State anxiety scores were significantly negatively correlated with absolute gamma power in frontal (Fz, r = -0.484) and central (Cz, r = -0.523) regions, while trait anxiety scores were significantly negatively correlated with absolute gamma power in frontal (Fz, r = -0.523), central (Cz, r = -0.568), parietal (P7, r = -0.500; P8, r = -0.541), and occipital (O1, r = -0.510; O2, r = -0.480) regions.
Conclusions

The present study identified the significantly negative correlations between the anxiety level and gamma band power in fronto-central and posterior regions assessed at resting status. Further studies to confirm our findings and identify the neural correlates of anxiety are needed.
Estimating late toxicities based on multivariable NTCP models in patients of high-risk prostate cancer requiring pelvic nodal irradiation: Comparison between Proton beam therapy and helical tomotherapy
Authors: Chilukuri Srinivas , Sundar Sham , Patro Kartikeswar , Sawant Mayur , Sivaraman Rangasamy , Arjunan Manikandan , Panda Pankaj Kumar , Sharma Dayananda S , Jalali Rakesh 
Published: September 2021

Abstract
Purpose:To compare the estimated late gastrointestinal (GI) and genitourinary (GU) toxicities between pencil beam scanning proton bream therapy (PBT) and helical Tomotherapy (HT) in patients of high-risk prostate cancers requiring pelvic nodal irradiation (PNI) using moderate hypo-fractionated regimen.Materials and MethodsTwelve consecutive patients treated with PBT at our centre were re-planned with HT using the same dose prescription and constraints. Late GI and GU toxicities were estimated based on the published NTCP models using clinico-dosimetric parameters. ΔNTCP (difference in absolute NTCP between HT and PBT plans) for each toxicity domains for all patients were calculated. Based on ΔNTCP, model-based selection (MBS) thresholds for PBT were applied on the dataset. One-Sample Kolmogorov-Smirnov test was used to analyze distribution of data and either Paired T-test or Wilcoxon matched-pair signed rank test was used to test statistical significance. ResultsPBT and HT plans achieved adequate target coverage. PBT plans led to significantly better sparing of bladder, rectum and bowel bag especially in the intermediate range of 15-40Gy; whereas doses to penile bulb and femoral heads were higher with PBT plans. The average ΔNTCP for grade(G)2-rectal bleeding, G2-fecal incontinence, G2-stool frequency, G2-dysuria, G2-urinary incontinence and G1-hematuria were 12.17%, 1.67%, 2%, 5.83%, 2.42% and 3.91% respectively favoring PBT plans. The average cumulative ΔNTCP for GI and GU toxicities (ΣΔNTCP) were 16.58% (8.25-24.95; 95% CI) and 11.41%(6.8-16.05) respectively favoring PBT. On applying the MBS threshold of any G2 ΔNTCP >10%, 8 (67%) patients would have qualified for PBT.Conclusion:PBT plans led to superior OAR sparing compared to HT which translated to lower NTCP for late moderate GI and GU toxicities in patients of prostate cancer treated with PNI. For two-thirds of our patients, the difference in estimated absolute NTCP values between PBT and HT, crossed the accepted threshold for minimal clinically important difference.
Emergency Department Visits with Obstructive Sleep Apnea in the United States
Authors: Guo Jianguo , Sun Mengzhu , Liu Yan-Cun , Pei Jiao , Fan Hui , Zhang Xingyu 
Published: September 2021

Abstract
Background: We aimed to reveal the differences among patients with OSA and without OSA in the Emergency Department (ED), including the utilization medical resources and treatment status. Methods: Using 2016–2017 ED data from the National Hospital Ambulatory Medical Care Survey, we investigated demographics, ED resource utilization, clinical characteristics, and the relationship with other diseases of patients with OSA versus those without OSA. Results: About 5,985,955 (2.8%) out of 215,240,000 annual ED visits were by patients with OSA. Among all of the reasons for ED Visit, patients with OSA who with Respiratory symptoms were 1.38 times (95% CI:1.06-1.78) more likely to seek for treatment than those with general symptoms, and who with Cardiovascular and Lymphatic symptoms were 1.44 times (95% CI:0.96-2.17) more likely to seek for treatment than those with general symptoms. In terms of gender, males were 1.28 times (95% CI:1. 10-1.48) more likely to have OSA than females. The hospital admission rate (30.3% vs. 13.7%, 95% CI: 1.47-2.11) and ICU admission rate (4.3% vs. 1.7%, 95% CI: 1.06-2.32) of OSA patients were higher than those of non OSA patients, also they were more likely to die in the ED or hospital (26.6%, P< 0.01) . Besides, rate of blood tests performed was 1.94 times higher (95% CI: 1.61-2.33), rate of any imaging performed was 1.63 times higher (95% CI: 1.37-1.92), rate of X-rays performed in ED was 1.54 times higher (95% CI: 1.31-1.81).Conclusions: By using the NHAMCS-ED dataset, we described the demographics, ED resource utilization, and clinical characteristics of Emergency Department patients with OSA. Based on that, the ED patients with OSA will increase the hospitalization rate, the ICU admission rate, adverse outcomes, and occupation of medical resources. Therefore, we should pay attention to the process of diagnosis and treatment of patients with OSA, in order to reduce the physiological and economic burden of patients, and improve the quality of life of patients.
Co-Designing Health Interventions With Refugee Communities – A Scoping Review.
Authors: Bartlett Rebeccah , Watterson Jessica , Boyle Jacqueline 
Published: September 2021

Abstract
BackgroundAs of June 2020, there were more than 79.5 million people displaced from their homes globally. Despite significantly different lived experiences, health literacy is poor within most displaced communities, contributing to low awareness and uptake of healthcare services and poor health outcomes as a result. Co-designing health interventions with communities is not a new concept however it is experiencing a significant increase in interest and support within the global health movement and areas of health equity in particular. This scoping review examines the current literature and gaps related to co-designing health interventions with refugees in order to increase health literacy; provide health services; and/or build quantitative data on health needs specific to refugee communities.MethodsThe following three questions were drafted and incorporated into a PICO framework.1. What literature exists surrounding co-designing health interventions with refugee populations?2. What effect (if any) do existing co-designed health interventions have on health outcomes (as defined above) within refugee populations?3. What gaps persist in co-designing health interventions with refugee communities? Key search terms were developed aiming to locate academic literature located within a Venn diagram of three categories: health, refugees and co-design. ResultsCombined searches uncovered a total of 1,804 articles following removal of duplications. 1,750 articles were excluded following screening of title and abstract leaving a shortlist of 54 articles. Only 10 of these articles met PICO criteria and nine of these focused exclusively on co-designing health interventions with refugee populations applied qualitative techniques. Only one article addressed all three health outcomes listed in the inclusion criteria above and half the articles did not discuss intervention outcomes or include any form of process evaluation.ConclusionsThis scoping review presents an opportunity to explore the intersection of collaborative design and health innovation with refugee communities. To ensure health interventions improve health outcomes, communities directly affected by displacement must be supported to authentically participate in, and where possible lead, efforts to co-design within this context. Future research efforts should expand to focus on evaluating the outcomes of ethical, meaningful and representative collaboration.
Secular trends in cryoglobulinemia mortality in the United States in the era of direct-acting antivirals
Authors: Guo Qianyu , Gao Jinfang , Duan Jiaoniu , Hou Ruihong , Zhang Liyun , Lu Tsung-Hsueh 
Published: September 2021

Abstract
Background

Hepatitis C virus (HCV) is the main etiology of cryoglobulinemia with mortality around 25%. Little is known on the changes in cryoglobulinemia mortality after the introduction of direct-acting antivirals (DAA) for treatment of HCV in 2014 in the US.
Methods

We calculated cryoglobulinemia mortality from 1999 to 2018. The proportionate mortality ratio (PMR) of cryoglobulinemia cases with HCV and those with autoimmune diseases were computed to assess the impact of introduction of DAA.
Results

We identified 1299 people aged ≥ 20 years who died with cryoglobulinemia between 1999 and 2018. The cryoglobulinemia mortality (deaths per million) declined from 1999 (0.4) to 2010 (0.22) and mildly increased from 2010 to 2014 (0.26), and then decreased abruptly from 2014 to 2018 (0.19). The proportion of cryoglobulinemia patients with HCV was 39% (118/302) in 2009–2013 and 26% (81/310) in 2014–2018, with a PMR of 0.67 (95% CI 0.50–0.89). By contrast, the proportion of cryoglobulinemia patients with systemic autoimmune diseases was 2.6% (8/302) in 2009–2013 and 4.2% (13/310) in 2014–2018, with a PMR of 1.58 (95% CI 0.66–3.82).
Conclusion

The changes in cryoglobulinemia mortality during the past two decades are mainly related to the aging and dying of the “baby boomer” cohort who had a high HCV prevalence and to the introduction of a DAA in 2014.
Symptom of Hemifacial Spasm Is Not Affected By State of Consciousness: A Case Report
Authors: Li Tao , Feng Zhuo , Song Chunli , Liang Zhanhua 
Published: September 2021

Abstract
Background: Hemifacial spasm is characterised by twitching of the muscles innervated by facial nerve. It is believed to result from hyperexcitability of the facial nerve nucleus or ephaptic transmission within the proximal facial nerve segment of the facial nerve nucleus. Often we observe spasm in an awakening situation. Actually contractions persist during sleep. To our knowledge, there were no reports on how it manifests under disturbance of consciousness. Herein we report a case whose symptoms sustained under coma status.Case presentation: A 74-year-old female suffered from right side primary hemifacial spasm for 20 years and used to accept botulinum toxin injection in our clinic. Unfortunately she was carried to emergency department in our hospital after traumatic right pneumothorax by accident. During emergency rescue cardiac arrest and apnea happened. She was then hospitalized in emergency intensive care unit for further therapy. During hospitalization, she was under coma status. Vital signs were stable and symptoms of hemifacial spasm sustained. A multidisciplinary consultation was request to identify whether it was focal cortical seizures involving the right side facial muscles. Physical examination revealed brief involuntary clonic or tonic contractions accompanied with the ‘Babinski-2’ sign. Synthesize the relevant data including past history, clinical manifestation and negative head computed tomography scanning, diagnosis was made as hemifacial spasm. Herein symptoms of hemifacial spasm were not life threatening and anti-epileptic drug was not necessary.Conclusions: It’s better for nonspecialists to prompt diagnose instead of under or misdiagnose the symptoms as seizures as inappropriate diagnostic or therapeutic measures may be taken inadvertently.
Application of Proximal Tibial Bone Cutting Block Without Guide Rod In Total Knee Arthroplasty: A Technical Note
Authors: Lv Shuai-Jie , Chu Xiaobing 
Published: September 2021

Abstract
Background The tibial bone cutting can affect the postoperative mechanical axis (MA), joint function and prosthesis life in total knee arthroplasty (TKA). Traditional intramedullary or extramedullary positioning systems have the possibility of embolization, difficulty in positioning and prolonged operation time. A bone cutting guide block with a fixed posterior slope angle (PSA) also may change the original physiological PSA. Methods We describe a tibial bone cutting technique with the help of a new tibial bone cutting guide block without a positioning rod. The positioning plate and metal probe were used to determine the PSA and thickness of bone cutting by preoperative X-ray measurement according to the preoperative measurement. Results The tibial bone cutting block without guide rod can keep the physiological PSA, reduce the error and operating time of the traditional positioning method in surgery. Conclusion This technique may be a good option for TKA patients, especially those with tibial deformities. Trial registration: retrospectively registered
Forecasting electricity consumption in Shanghai using a nonlinear interval grey model
Authors: WU Zhiqiang , GAO Yan , WANG Bo 
Published: September 2021

Abstract
Carbon emissions from fossil energy not only cause a lot of extreme weathers, but also global warming. Accurately forecasting of electricity demand can promote the development of the renewable energy, which is vital to achieving the goal of carbon peak and carbon neutrality. In this paper, a nonlinear interval grey model based on genetic algorithm and BP neural network optimization (BPGA-IGM (1,1)) is proposed to predict electricity consumption. Firstly, based on the forecast of China's energy consumption and China's coal consumption, the reliability and superiority of the BPGA-IGM (1,1) model have been verified. Then, the model and other competing models are applied to forecast Shanghai's electricity consumption. The empirical results show that the model designed in this paper could obtain more accurate and reliable prediction results. According to the empirical results, Shanghai's electricity consumption continues to rise to a higher level of no less than 1978.19 million kWh by 2025. On the basis of this issue, several suggestions have been offered.