bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of herpes zoster vaccination on incident dementia: A retrospective study in two patient cohorts
Authors: Scherrer Jeffrey F. , Salas Joanne , Wiemken Timothy L. , Hoft Daniel F. , Jacobs Christine , Morley John E. 
Published: November 2021

BackgroundHerpes zoster (HZ) infection increases dementia risk, but it is not known if herpes zoster vaccination is associated with lower risk for dementia. We determined if HZ vaccination, compared to no HZ vaccination, is associated with lower risk for incident dementia.Methods and findingsData was obtained from Veterans Health Affairs (VHA) medical records (10/1/2008–9/30/2019) with replication in MarketScan® commercial and Medicare claims (1/1/2009-12/31/2018). Eligible patients were ≥65 years of age and free of dementia for two years prior to baseline (VHA n = 136,016; MarketScan n = 172,790). Two index periods (either start of 2011 or 2012) were defined, where patients either had or did not have a HZ vaccination. Confounding was controlled with propensity scores and inverse probability of treatment weighting. Competing risk (VHA) and Cox proportional hazard (MarketScan) models estimated the association between HZ vaccination and incident dementia in all patients and in age (65–69, 70–74, ≥75) and race (White, Black, Other) sub-groups. Sensitivity analysis measured the association between HZ vaccination and incident Alzheimer’s dementia (AD). HZ vaccination at index versus no HZ vaccination throughout follow-up. VHA patients mean age was 75.7 (SD±7.4) years, 4.0% were female, 91.2% white and 20.2% had HZ vaccination. MarketScan patients mean age was 69.9 (SD±5.7) years, 65.0% were female and 14.2% had HZ vaccination. In both cohorts, HZ vaccination compared with no vaccination, was significantly associated with lower dementia risk (VHA HR = 0.69; 95%CI: 0.67–0.72; MarketScan HR = 0.65; 95%CI:0.57–0.74). HZ vaccination was not related to dementia risk in MarketScan patients aged 65–69 years. No difference in HZ vaccination to dementia effects were found by race. HZ vaccination was associated with lower risk for AD.ConclusionsHZ vaccination is associated with reduced risk of dementia. Vaccination may provide nonspecific neuroprotection by training the immune system to limit damaging inflammation, or specific neuroprotection that prevents viral cytopathic effects.
Individual determinants of COVID-19 vaccine hesitancy
Authors: Gerretsen Philip , Kim Julia , Caravaggio Fernando , Quilty Lena , Sanches Marcos , Wells Samantha , Brown Eric E. , Agic Branka , Pollock Bruce G. , Graff-Guerrero Ariel 
Published: November 2021

Background
Novel coronavirus disease 2019 (COVID-19) vaccine hesitancy is a barrier to achieving herd immunity, and thus, a prominent public health concern. This study aimed to identify the determinants of COVID-19 vaccine hesitancy based on the World Health Organization’s ‘3Cs’ model (i.e., confidence, complacency, and convenience) in the United States (U.S.) and Canada.

Methods
Data from 7678 adults ages 18 or older were collected from the four most populous U.S. States, specifically New York, California, Florida, and Texas, and from English-speaking Canada at three timepoints, in May and July 2020, and March 2021 using a web-based survey (www.covid19-database.com). Sociodemographic information was collected, and comprehensive psychological assessments were administered. Univariate analyses were performed to identify the individual determinants of vaccine hesitancy, which were categorized as: 1) vaccine confidence, 2) vaccine complacency, 3) sociodemographic, and 4) other psychological factors. A series of models were computed using these categorizations.

Results
Mistrust of vaccine benefit (β(SE) = 0.67(0.01), p<0.001, partial η2 = 0.26) and lower perceived seriousness of COVID-19 (β(SE) = 0.68(0.02), p<0.001, partial η2 = 0.12) were the principal determinants of vaccine hesitancy. Right-wing political affiliation (β(SE) = 0.32(0.02), p<0.001, partial η2 = 0.03), higher risk propensity (β(SE) = 0.24(0.02), p<0.001, partial η2 = 0.03), and less negative mental health effects of the COVID-19 pandemic (β(SE) = 0.20(0.01), p<0.001, partial η2 = 0.03) were the main sociodemographic and psychological determinants. Other sociodemographic determinants included younger age, women, race, and employment status. Lack of vaccine confidence and complacency explained 38% and 21% of the variance in vaccine hesitancy, respectively; whereas, sociodemographic and psychological determinants explained 13% and 11% of the variance in vaccine hesitancy, respectively.

Discussion
Targeted and tailored public health interventions that enhance the public’s confidence in vaccines and emphasize the risk and seriousness of COVID-19 may address COVID-19 vaccine hesitancy. Efforts directed toward specific marginalized and underserved groups may be required to promote vaccine confidence.
A randomised controlled trial of the 5:2 diet
Authors: Hajek Peter , Przulj Dunja , Pesola Francesca , McRobbie Hayden , Peerbux Sarrah , Phillips-Waller Anna , Bisal Natalie , Myers Smith Katie 
Published: November 2021

Objective
The 5:2 diet is a popular intermittent energy restriction method of weight management that awaits further evaluation. We compared the effects of one-off 5:2 instructions with the effects of one-off standard multicomponent weight-management advice; and also examined whether additional behavioural support enhances 5:2 adherence and efficacy compared to one-off instructions.

Methods
Three hundred adults with obesity were randomised to receive a Standard Brief Advice (SBA) covering diet and physical activity (N = 100); 5:2 self-help instructions (5:2SH) (N = 100); or 5:2SH plus six once-weekly group support sessions (N = 100). Participants were followed up for one year.

Results
Adherence to 5:2SH was initially high (74% at 6 weeks), but it declined over time (31% at 6 months and 22% at one year). 5:2SH and SBA achieved similar weight-loss at six months (-1.8kg (SD = 3.5) vs -1.7kg (SD = 4.4); b = 0.23, 95%CI:-0.79–1.27, p = 0.7) and at one year (-1.9kg (SD = 4.9) vs -1.8kg (SD = 5.7), b = 0.20, 95%CI:-1.21–1.60, p = 0.79), with 18% vs 15% participants losing ≥5% of their body weight with 5:2SH and SBA, respectively at one year (RR = 0.83, 95%CI:0.44–1.54, p = 0.55). Both interventions received positive ratings, but 5:2SH ratings were significantly higher. 5:2SH had no negative effect on fat and fiber intake and physical activity compared to SBA. Compared to 5:2SH, 5:2G generated a greater weight loss at 6 weeks (-2.3kg vs -1.5kg; b = 0.74, 95%CI:1.37–0.11, p = 0.02), but by one year, the difference was no longer significant (-2.6kg vs -1.9kg, p = 0.37; ≥5% body weight loss 28% vs 18%, p = 0.10).

Conclusions
Simple 5:2 advice and multicomponent weight management advice generated similar modest results. The 5:2 diet did not undermine other health behaviours, and it received more favourable ratings. Adding initial group support enhanced 5:2 adherence and effects, but the impact diminished over time. Health professionals who provide brief weight management advice may consider including the 5:2 advice as an option.

Trial registration
ISRCTN registry (ISRCTN79408248).
Differences in mortality and causes of death between STEMI and NSTEMI in the early and late phases after acute myocardial infarction
Authors: Takeji Yasuaki , Shiomi Hiroki , Morimoto Takeshi , Yamamoto Ko , Matsumura-Nakano Yukiko , Nagao Kazuya , Taniguchi Ryoji , Yamaji Kyohei , Tada Tomohisa , Kato Eri Toda , Yoshikawa Yusuke , Obayashi Yuki , Suwa Satoru , Inoko Moriaki , Ehara Natsuhiko , Tamura Toshihiro , Onodera Tomoya , Watanabe Hiroki , Toyofuku Mamoru , Nakatsuma Kenji , Sakamoto Hiroki , Ando Kenji , Furukawa Yutaka , Sato Yukihito , Nakagawa Yoshihisa , Kadota Kazushige , Kimura Takeshi ,   the CREDO-Kyoto AMI Registry Wave-2 Investigators
Published: November 2021

Background
The detailed causes of death in non–ST-segment–elevation myocardial infarction (NSTEMI) have not been adequately evaluated compared to those in ST-segment elevation myocardial infarction (STEMI).

Methods
The study population was 6,228 AMI patients who underwent percutaneous coronary intervention (STEMI: 4,625 patients and NSTEMI: 1,603 patients). The primary outcome was all-cause death.

Results
Within 6 months after AMI, the adjusted mortality risk was not significantly different between NSTEMI patients and STEMI patients (HR: 0.83, 95%CI: 0.67–1.03, P = 0.09). Regarding the causes of death within 6 months after AMI, mechanical complications more frequently occurred in STEMI patients than in NSTEMI patients, while proportions of post resuscitation status on arrival and heart failure were higher in in NSTEMI patients than in STEMI patients. Beyond 6 months after AMI, the adjusted mortality risk of NSTEMI relative to STEMI was not significantly different. (HR: 1.04, 95%CI: 0.90–1.20, P = 0.59). Regarding causes of death beyond 6 months after AMI, almost half of deaths were cardiovascular causes in both groups, and breakdown of causes of death was similar between NSTEMI and STEMI.

Conclusion
The mortality risk within and beyond 6 months after AMI were not significantly different between STEMI patients and NSTEMI patients after adjusting confounders. Deaths due to post resuscitation status and heart failure were more frequent in NSTEMI within 6 months after AMI.
Cost-effectiveness analysis protocol of the Smart Triage program: A point-of-care digital triage platform for pediatric sepsis in Eastern Uganda
Authors: Li Edmond C. K. , Grays Sela , Tagoola Abner , Komugisha Clare , Nabweteme Annette Mary , Ansermino J. Mark , Mitton Craig , Kissoon Niranjan , Khowaja Asif R. 
Published: November 2021

Background
Sepsis is a clinical syndrome characterized by organ dysfunction due to presumed or proven infection. Severe cases can have case fatality ratio 25% or higher in low-middle income countries, but early diagnosis and timely treatment have a proven benefit. The Smart Triage program in Jinja Regional Referral Hospital in Uganda will provide expedited sepsis treatment in children through a data-driven electronic patient triage system. To complement the ongoing Smart Triage interventional trial, we propose methods for a concurrent cost-effectiveness analysis of the Smart Triage platform.

Methods
We will use a decision-analytic model taking a societal perspective, combining government and out-of-pocket costs, as patients bear a sizeable portion of healthcare costs in Uganda due to the lack of universal health coverage. Previously published secondary data will be used to link healthcare utilization with costs and intermediate outcomes with mortality. We will model uncertainty via probabilistic sensitivity analysis and present findings at various willingness-to-pay thresholds using a cost-effectiveness acceptability curve.

Discussion
Our proposed analysis represents a first step in evaluating the cost-effectiveness of an innovative digital triage platform designed to improve clinical outcomes in pediatric sepsis through expediting care in low-resource settings. Our use of a decision analytic model to link secondary costing data, incorporate post-discharge healthcare utilization, and model clinical endpoints is also novel in the pediatric sepsis triage literature for low-middle income countries. Our analysis, together with subsequent analyses modelling budget impact and scale up, will inform future modifications to the Smart Triage platform, as well as motivate scale-up to the district and national levels.

Trial registration
Trial registration of parent clinical trial: NCT04304235, https://clinicaltrials.gov/ct2/show/NCT04304235. Registered 11 March 2020.
Interaction effect of coping self-efficacy and received support in daily life of hematopoietic cell transplant patient-caregiver dyads
Authors: Kroemeke Aleksandra , Sobczyk-Kruszelnicka Małgorzata 
Published: November 2021

Objectives
According to the social cognitive theory, social support and self-efficacy may interact with each other i.e. compete or account jointly for better adaptation. This study examined the nature of the interaction between coping self-efficacy and received social support in daily lives of patient-caregiver dyads after cancer treatment. We tested whether the effect of daily fluctuations in coping self-efficacy and received support on daily affect was synergistic (positive jointed effect), compensatory (positive competing effect), or interference (negative competing effect).

Design
A dyadic daily-diary study conducted for 28 days after hospital discharge following hematopoietic cell transplantation.

Methods
Coping self-efficacy, received support, and positive and negative affect were measured in 200 patient-caregiver dyads. The analysis was based on the actor-partner interdependence moderation model using multilevel structural equation modeling.

Results
Statistically significant effect of interaction between daily coping self-efficacy and received support on negative affect was found, although only in the caregivers. In that group, higher daily received support compensated for lower daily coping self-efficacy but had a negative effect when coping self-efficacy was significantly higher than typical. Also, direct beneficial effects of higher daily coping self-efficacy and received support on caregiver positive affect were found. In the patients, higher daily coping self-efficacy was directly associated with better daily affect.

Conclusions
Diverse effects of daily coping self-efficacy and received social support were found—the interference effect in the caregivers and the main effect of coping self-efficacy in the patients. Higher daily coping self-efficacy and optimal received social support may provide resilience against affect disturbance after cancer treatment.
Conservation-Restoration of a Botanical Museum Fluid Collection: Practice and Research
Authors: Dangeon M. , Cornet E. , Brambilla L. 
Published: November 2021

Abstract
The collection of the Botanical Museum of the University of Zürich is an academic collection assembled from 1891 to the end of the 20th century (1992 for the last inventoried item). Preserved plants come from all over the world (40 countries) and include all categories of existing Plantae (algae, lichens, fungi, higher plants, bacteriae). The fluid collection, largely neglected since 1976, shows significant degradation. The main problem is loss of preservative fluid due to leakage of the jars and aging of the seals. Another issue is the discoloration of the specimen fluids. These issues led to a research project titled FLUIDIS, which aimed to explore different preservative solutions and their impact on the discoloration of plant specimens. Conservation-restoration work was carried out on the jars of the “Professor Ernst Collection.” Topping up of was necessary for the entire collection. Restoration was performed after opening the containers and identifying the fluid. The specimens were consolidated, repaired, and mounted when necessary, then gradually put back into alcoholic solutions and finally sealed. An overall intervention protocol was established for the treatment of the entire botanical fluid collection. Its application, however, requires a careful study of each specimen.
Mind, Body, and Race in Jessie Redmon Fauset’s Plum Bun
Authors: Mikić Marijana 
Published: November 2021

Abstract
Working at the intersection of cognitive and critical race narratology, the essay examines the relationship between the embodied mind and the social construction of race in Jessie Redmon Fauset’s Plum Bun: A Novel Without a Moral (1928/2011). The essay argues that Fauset’s African American passing novel rejects the notion of a solely ‘inward turn’, which is commonly associated with modernist literature, in favor of a more dynamic understanding of embodied cognition that acknowledges the shaping force of race and racialization. Using a seemingly traditional omniscient narrator, Fauset not only draws attention to the failure of U. S. American racial hierarchies, but she also lays bare how race impacts both individual consciousness and social cognition.1
Iconographies of ‘Childness’ and the Contemporary British Novel: Book Covers, Discourses, and Cultural Models
Authors: Schneider Ralf 
Published: November 2021

Abstract
A sizeable segment of the contemporary British fiction market for adult readers consists of novels that focus on children and childhood. In accordance with interdisciplinary Childhood Studies, such texts can be understood as contributions to the social construction of children and childhood, or ‘childness’. Such constructions appear to be in particular demand in this phase of late modernity, when childhood is conceptualized as an antidote to the many uncertainties contemporary post-industrial societies are faced with. While on the level of societies, public constructions of childhood are best understood in terms of a Foucauldian notion of discourse, discourses are not what individual readers and book-buyers actually have in their minds when choosing a title. Rather, this article argues that the cover illustrations of these novels both activate and reinforce cultural models of ‘childness’ that readers have stored as schemata shared with their cultural community. On the basis of this alignment of discourse theory with a concept from cognitive anthropology, the article demonstrates that book covers play a role in maintaining particular conceptions of ‘childness’, and in feeding them back into the minds of the readers. Furthermore, the relevance of the book as a material artefact is once again acknowledged.1
Evaluation of yield and quality properties of Elaeagnus mollis oil produced by ultrasound-assisted solvent enzymatic extraction
Authors: Lu Xiao-rui , Wu Dan , Wang Yong , Li Dong , Wang Li-jun 
Published: November 2021

Abstract
To improve the extraction efficiency and quality, ultrasound-assisted solvent enzymatic extraction (UASEE) method was applied to extract oil from Elaeagnus mollis Diels. The soxhlet extraction (SE) and cold pressing (CP) were carried out to be compared with UASEE. The optimal UASEE conditions were liquid–solid ratio of 11.6 mL/g, enzyme amount of 1.1%, and ultrasound power of 583 W, which gave by Plackett–Burman and Box–Behnken design. Under optimum conditions, the oil yield of 43.35 ± 0.26% was reached, which was similar to that of SE (43.02 ± 0.77%). The oil obtained by UASEE is more desirable than that of SE, but similar with CP, especially on unsaturated fatty acids content and total tocopherol content. Overall, UASEE is a potential alternative to traditional methods for the efficient extraction of E. mollis oil for its higher oil yield and better quality.
Artificial intelligence, big data, and blockchain in food safety
Authors: Zhou Qinqin , Zhang Hao , Wang Suya 
Published: November 2021

Abstract
Food safety plays an essential role in our daily lives, and it becomes serious with the development of worldwide trade. To tackle the food safety issues, many advanced technologies have been developed to monitor the process of the food industry (FI) to ensure food safety, including the process of food production, processing, transporting, storage, and retailing. These technologies are often referred to as artificial intelligence (AI), big data, and blockchain, which have been widely applied in many research areas. In this review, we introduce these technologies and their applications in the food safety domain. Firstly, basic concepts of these technologies are presented. Then, applications for food safety from a data perspective based on these technologies are analyzed. Finally, future challenges of the applications of AI, big data, and blockchain are discussed.
Process Influences in the Combined Compacting and Back-Injection Process to Produce Back-Injected Self-Reinforced Composites (SRCs) – Analysis via Multiple Regression Modelling
Authors: Jakob F. , Pollmeier J. , Heim H.-P. 
Published: November 2021

Abstract
A new process to produce back-injected self-reinforced composites (SRCs) is presented. In contrast to other investigations on back-injection of SRCs, a process is presented which allows compacting and back injection of SRCs in one step where the SRCs are partly consolidated only via melt pressure inside the cavity. The mechanical properties of SRCs depend to a large extent on the process parameters of temperature and pressure during manufacture. These parameters are not yet known for back-injected areas. Sensors inside of the cavity measure the influences on the temperature and pressure conditions in the cavity. Initial studies on adhesion were carried out and analysed. For this purpose, shear tests of the back-injected component were carried out and a maximum shear strength of 5.81 MPa was determined for the materials used here. The investigations also show a dependence on the Distance from the Gate (DG) and the Mass temperature (TM). First microscopic examinations show good bonding between the SRC and the injection molded part, with no voids or air pockets in the boundary layer. It can also be seen that successful consolidation takes place in the area of the back injection.
Does Premature Deindustrialization Matter? The Role of Manufacturing versus Services in Development
Authors: Nayyar Gaurav , Cruz Marcio , Zhu Linghui 
Published: November 2021

Abstract“Premature deindustrialization” typically reflects the fact that the services sector has grown faster than manufacturing at lower levels of per capita income compared to the past. This paper, based on cross-country data, shows that the rising share of services is largely not driven by a statistical artifact whereby what was earlier subsumed in manufacturing value added is now accounted for as service sector contributions. Yet, this matters less for development opportunities because features of manufacturing that were thought of as uniquely special for productivity growth are also shared by some services. And the growth of these high-productivity services is not closely linked to a manufacturing base as it draws on both intermediate demand from other sectors as well as final demand from home and abroad. The prospect of services-led development in lower-income countries however, is limited by the fact that a given service subsector is unlikely to provide opportunities for productivity growth and job creation for unskilled labor simultaneously.
Squeezing Italian dictionaries in search of citrus juice and fruit
Authors: Corino Elisa , Marello Carla 
Published: November 2021

Abstract
Southern Mediterranean regions significantly differ from the northern countries not only for their climate, but also and foremost for the influence that the latter has on the landscape and the products that are related to it. Dictionaries should relate the lexical variation used to describe the variety of landscapes and their characteristics, thus reflecting the peculiarities of a given territory.
This paper deals with the variety of citrus fruits that can be found in the Italian landscapes, with particular attention to the lexicographic treatment that they receive in both monolingual and bilingual dictionaries, where a precise meaning is not always registered and the treatment of the superordinate agrume (pl. agrumi) is controversial: its taxonomic status seems not to be recognized and fully exploited in dictionary articles.