bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zooming Into Summer: Key Takeaways From a Virtual Summer Reading Intervention
Authors: Washburn Erin K. , Beach Kristen D. , Gesel Samantha A. , Billingsley MaryCatherine , Howard Chelsea , King BreAnn , Vintinner Jean Payne 
Published: April 2021

AbstractThe aim of this teaching tip is to share four key takeaways from virtual implementation of a reading intervention in a four‐week summer reading camp (SRC) for rising second‐ and third‐grade students in need of foundational skills support. The SRC, which was a partnership between a university and school district, pivoted to a virtual format for summer 2020 as a result of the COVID‐19 global pandemic. Through information collected during SRC observations and a series of semistructured focus group interviews with SRC teachers, staff, and participating families, the authors found: (a) connecting with families is fundamental, (b) creating a positive virtual learning space is essential, (c) methods and materials for virtual learning matter, and (d) the learning curve for virtual teaching needs ongoing support. Details and ideas are shared for each takeaway with the goal of supporting educators with virtual implementation of reading intervention.
The Stieltjes condition and multidimensional $${\mathcal {K}}$$-moment problems
Authors: Schmüdgen Konrad 
Published: April 2021

AbstractWe prove a solvability theorem for the Stieltjes problem on $$\mathbb {R}^d$$

R

d

which is based on the multivariate Stieltjes condition $$\sum _{n=1}^\infty L(x_j^{n})^{-1/(2n)} =+\infty $$

∑

n
=
1

∞

L

(

x
j
n

)

-
1
/
(
2
n
)

=
+
∞

, $$j=1,\dots ,d.$$

j
=
1
,
⋯
,
d
.

This result is applied to derive a new solvability theorem for the moment problem on unbounded semi-algebraic subsets of $$\mathbb {R}^d$$

R

d

.
Erfassung der Labortestungen auf SARS-CoV-2 in Deutschland
Authors: Seifried Janna , Hoffmann Alexandra , Reda Sarah , Böttcher Sindy , Abu Sin Muna , Hofmann Alexandra , Noll Ines , von Laer Anja , Reuss Annicka , Oh Djin-Ye , Albrecht Stefan , Stern Daniel , Willrich Niklas , Staat Doreen , Zacher Benedikt , Schneider Marc , Feig Marcel , Nitsche Andreas , Rieck Thorsten , Rexroth Ute , Eckmanns Tim , Hamouda Osamah 
Published: April 2021

ZusammenfassungDie Erfassung von Daten zu SARS-CoV-2-Testungen in Deutschland sind für die Einschätzung des Infektionsgeschehens im Rahmen der COVID-19-Pandemie von zentraler Bedeutung. Am Robert Koch-Institut (RKI) werden dazu die Daten aus verschiedenen Systemen zur Erfassung von Labortestungen zusammengeführt. In diesem Beitrag werden zunächst bedeutsame Aspekte der Testverfahren erläutert. Nachfolgend werden die unterschiedlichen Systeme zur Erfassung von Labortestungen erläutert und Testzahlen aus der RKI-Testlaborabfrage und der laborbasierten Surveillance SARS-CoV‑2 sowie die Abrechnungsdaten der kassenärztlichen Vereinigungen zu SARS-CoV-2-Labortestungen dargestellt.Mit der RKI-Testlaborabfrage und der laborbasierten Surveillance SARS-CoV‑2 stand früh in der Pandemie eine Surveillance zur Verfügung, mit der unter den teilnehmenden Laboren Daten zu durchgeführten Testungen und Testkapazitäten ausgewertet werden können. Durch die Erfassung von positiven und negativen Testergebnissen sind Aussagen zur Gesamtzahl der durchgeführten Testungen sowie dem Anteil der positiven Testergebnisse möglich. Während die aggregierten Testzahlen bundesweit weitestgehend repräsentativ sind, ist die Repräsentativität auf Bundesland- und Landkreisebene aber nicht immer gegeben. Die Abrechnungsdaten der Kassenärztlichen Vereinigungen können die Labordaten im Nachhinein ergänzen. Sie erlauben eine retrospektive Einschätzung der Gesamtzahl von SARS-CoV-2-Tests in Deutschland, da die Leistungen der vertragsärztlichen Versorgung aller gesetzlich Krankenversicherten (ca. 85 % der Bevölkerung) enthalten sind.Die verschiedenen Systeme zur Erfassung von Labortestungen ergänzen sich gegenseitig. Die Auswertungen fließen in die Maßnahmenempfehlungen zur Pandemiebewältigung ein.
Inferring Switched Nonlinear DynamicalSystems
Authors: Jin Xiangyu , An Jie , Zhan Bohua , Zhan Naijun , Zhang Miaomiao 
Published: April 2021

AbstractIdentification of dynamical and hybrid systems using trajectory data is an important way to construct models for complex systems where derivation from first principles is too difficult. In this paper, we study the identification problem for switched dynamical systems with polynomial ODEs. This is a difficult problem as it combines estimating coefficients for nonlinear dynamics and determining boundaries between modes. We propose two different algorithms for this problem, depending on whether to perform prior segmentation of trajectories. For methods with prior segmentation, we present a heuristic segmentation algorithm and a way to classify themodes using clustering. Formethods without prior segmentation, we extend identification techniques for piecewise affine models to our problem. To estimate derivatives along the given trajectories, we use Linear MultistepMethods. Finally, we propose a way to evaluate an identified model by computing a relative difference between the predicted and actual derivatives. Based on this evaluation method, we perform experiments on five switched dynamical systems with different parameters, for a total of twenty cases. We also compare with three baseline methods: clustering with DBSCAN, standard optimization methods in SciPy and identification of ARX models in Matlab, as well as with state-of-the-art identification method for piecewise affine models. The experiments show that our two methods perform better across a wide range of situations.
Improving insulin sensitivity, liver steatosis and fibrosis in type 2 diabetes by a food-based digital education-assisted lifestyle intervention program: a feasibility study
Authors: Zaharia Oana P. , Kupriyanova Yuliya , Karusheva Yanislava , Markgraf Daniel F. , Kantartzis Konstantinos , Birkenfeld Andreas L. , Trenell Michael , Sahasranaman Aarti , Cheyette Chris , Kössler Theresa , Bódis Kálmán , Burkart Volker , Hwang Jong-Hee , Roden Michael , Szendroedi Julia , Pesta Dominik H. 
Published: April 2021

Abstract
Purpose
Recent trials demonstrated remission of type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) following formula diet-induced weight loss. To improve the outreach for populations in need, many mobile health apps targeting weight loss have been developed with limited scientific evaluation of these apps. The present feasibility study investigated the effects of a novel approach incorporating a regular ‘whole food-based’ low-calorie diet combined with app-based digital education and behavioral change program on glucose metabolism and disease management.

Methods
Twenty-four individuals with type 2 diabetes followed this approach supported by weekly coaching calls for 12 weeks. Phenotyping included bioimpedance analysis, mixed-meal tolerance test, magnetic resonance spectroscopy and transient elastography for assessing liver fat content and liver stiffness.

Results
Over 12 weeks, participants reduced their body weight by 9% (97 ± 13 to 88 ± 12 kg), body mass index (BMI; 33 ± 5 to 29 ± 4 kg/m2), total fat mass (31 ± 10 to 27 ± 10%) (all p < 0.01) and liver fat by 50% alongside with decreased liver stiffness. Target HbA1c (< 6.5%) was achieved by 38% and resolution of NAFLD (liver fat content < 5.6%) was observed in 30% of the participants.

Conclusion
This novel approach combining digital education with a low-calorie diet results in effective improvements of body weight, glycemic control and NAFLD and could complement existing care for patients with type 2 diabetes.

Trial registration
NCT04509245
Pseudoinverse graph convolutional networks
Authors: Alfke Dominik , Stoll Martin 
Published: April 2021

AbstractGraph Convolutional Networks (GCNs) have proven to be successful tools for semi-supervised classification on graph-based datasets. We propose a new GCN variant whose three-part filter space is targeted at dense graphs. Our examples include graphs generated from 3D point clouds with an increased focus on non-local information, as well as hypergraphs based on categorical data of real-world problems. These graphs differ from the common sparse benchmark graphs in terms of the spectral properties of their graph Laplacian. Most notably we observe large eigengaps, which are unfavorable for popular existing GCN architectures. Our method overcomes these issues by utilizing the pseudoinverse of the Laplacian. Another key ingredient is a low-rank approximation of the convolutional matrix, ensuring computational efficiency and increasing accuracy at the same time. We outline how the necessary eigeninformation can be computed efficiently in each applications and discuss the appropriate choice of the only metaparameter, the approximation rank. We finally showcase our method’s performance regarding runtime and accuracy in various experiments with real-world datasets.
A phase II clinical study on the efficacy and predictive biomarker of pegylated recombinant arginase on hepatocellular carcinoma
Authors: Chan Stephen L. , Cheng Paul N.M. , Liu Angela M. , Chan Landon L. , Li Leung , Chu Cheuk M. , Chong Charing C.N. , Lau Yat M. , Yeo Winnie , Ng Kelvin K.C. , Yu Simon C.H. , Mok Tony S.K. , Chan Anthony W.H. 
Published: April 2021

AbstractBackground: Pegylated recombinant human arginase (PEG-BCT-100) is an arginine depleting drug. Preclinical studies showed that HCC is reliant on exogenous arginine for growth due to the under-expression of the arginine regenerating enzymes argininosuccinate synthetase (ASS) and ornithine transcarbamylase (OTC). Methods: This is a single arm open-label Phase II trial to assess the potential clinical efficacy of PEG-BCT-100 in chemo naïve sorafenib-failure HCC patients. Pre-treatment tumour biopsy was mandated for ASS and OTC expression by immunohistochemistry (IHC). Weekly intravenous PEG-BCT-100 at 2.7 mg/kg was given. Primary endpoint was time to progression (TTP); secondary endpoints included radiological response as per RECIST1.1, progression free survival (PFS) and overall survival (OS). Treatment outcomes were correlated with tumour immunohistochemical expressions of ASS and OTC. Results: In total 27 patients were recruited. The median TTP and PFS were both 6 weeks (95% CI, 5.9–6.0 weeks). The disease control rate (DCR) was 21.7% (5 stable disease). The drug was well tolerated. Post hoc analysis showed that duration of arginine depletion correlated with OS. For patients with available IHC results, 10 patients with ASS-negative tumour had OS of 35 weeks (95% CI: 8.3–78.0 weeks) vs. 15.14 weeks (95% CI: 13.4–15.1 weeks) in 3 with ASS-positive tumour; expression of OTC did not correlate with treatment outcomes. Conclusions: PEG-BCT-100 in chemo naïve post-sorafenib HCC is well tolerated with moderate DCR. ASS-negative confers OS advantage over ASS-positive HCC. ASS-negativity is a potential biomarker for OS in HCC and possibly for other ASS-negative arginine auxotrophic cancers. Trial registration number: NCT01092091. Date of registration: March 23, 2010.
On an Implicit Model Linear in Both Stress and Strain to Describe the Response of Porous Solids
Authors: Itou Hiromichi , Kovtunenko Victor A. , Rajagopal Kumbakonam R. 
Published: April 2021

AbstractWe study some mathematical properties of a novel implicit constitutive relation wherein the stress and the linearized strain appear linearly that has been recently put into place to describe elastic response of porous metals as well as materials such as rocks and concrete. In the corresponding mixed variational formulation the displacement, the deviatoric and spherical stress are three independent fields. To treat well-posedness of the quasi-linear elliptic problem, we rely on the one-parameter dependence, regularization of the linear-fractional singularity by thresholding, and applying the Browder–Minty existence theorem for the regularized problem. An analytical solution to the nonlinear problem under constant compression/extension is presented.
New antidiabetic therapy and HFpEF: light at the end of tunnel?
Authors: Tadic Marijana , Sala Carla , Saeed Sahrai , Grassi Guido , Mancia Giuseppe , Rottbauer Wolfang , Cuspidi Cesare 
Published: April 2021

AbstractNew antidiabetic therapy that includes sodium-glucose co-transporter 2 (SGLT2) inhibitors, glucagon-like peptide-1 receptor (GLP-1R) agonists, and dipeptidyl peptidase 4 (DPP-4) inhibitors showed significant benefit on cardiovascular outcomes in patients with and without type 2 diabetes mellitus, and this was particularly confirmed for SGLT2 inhibitors in subjects with heart failure (HF) with reduced ejection fraction (HFrEF). Their role on patients with HF with preserved ejection fraction (HFpEF) is still not elucidated, but encouraging results coming from the clinical studies indicate their beneficial role. The role of GLP-1R agonists and particularly DPP-4 inhibitors is less clear and debatable. Findings from the meta-analyses are sending positive message about the use of GLP-1R agonists in HFrEF therapy and revealed the improvement of left ventricular (LV) diastolic function in HFpEF. Nevertheless, the relevant medical societies still consider their effect as neutral or insufficiently investigated in HF patients. The impact of DPP-4 inhibitors in HF is the most controversial due to conflicting data that range from negative impact and increased risk of hospitalization due to HF, throughout neutral effect, to beneficial influence on LV diastolic dysfunction. However, this is a very heterogeneous group of medications and some professional societies made clear discrepancy between saxagliptin that might increase risk of HF hospitalization and those DPP-4 inhibitors that have no effect on hospitalization. The aim of this review is to summarize current clinical evidence about the effect of new antidiabetic medications on LV diastolic function and their potential benefits in HFpEF patients.
Mediating Trauma and Anxiety: Letters to Françoise Dolto, 1976-1978
Authors: Bates Richard 
Published: April 2021

AbstractFrançoise Dolto (1908-88) was a prominent French cultural figure thanks to her practice of dispensing psychoanalytically-informed child-rearing advice via the radio. From 1976 to 1978, on her show Lorsque l’enfant paraît, she responded to thousands of letters sent in by listeners requesting help with parenting problems and personal questions of a psychological nature. The article explores Dolto’s cultural position as a child psychoanalyst – understood in the 1960s and 1970s as a radical profession – but from a conservative, Catholic background. It then examines a sample of the letters sent in to her show, analysing the demographics of the correspondents and highlighting their most common concerns. Finally the article studies the relationship between psychoanalysis and trauma. It indicates the anxiety that a psychoanalytic understanding can cause, by reinforcing parents’ fears that childhood traumas are common, can be created unwittingly by parents, and lead to major psychological consequences in later life.
Experimental determination of the temperature dependence of oxygen-isotope fractionation between water and chitinous head capsules of chironomid larvae
Authors: Lombino Alex , Atkinson Tim , Brooks Stephen J. , Gröcke Darren R. , Holmes Jonathan , Jones Vivienne J. , Marshall Jim D. 
Published: April 2021

AbstractOxygen-isotope values of invertebrate cuticle preserved in lake sediments have been used in palaeoenvironmental reconstructions, generally with the assumption that fractionation of oxygen isotopes between cuticle and water ($$\upalpha_{\text{cuticle}-\text{H}_{2}\text{O}}$$

α

cuticle
-

H
2

O

) is independent of temperature. We cultured chironomid larvae in the laboratory with labelled oxygen-isotope water and across a range of closely controlled temperatures from 5 to 25 °C in order to test the hypothesis that fractionation of oxygen isotopes between chironomid head capsules and water ($$\upalpha_{\text{chironomid}-\text{H}_{2}\text{O}}$$

α

chironomid
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H
2

O

) is independent of temperature. Results indicate that the hypothesis can be rejected, and that $$\upalpha_{\text{chironomid}-\text{H}_{2}\text{O}}$$

α

chironomid
-

H
2

O

decreases with increasing temperature. The scatter in the data suggests that further experiments are needed to verify the relationship. However, these results indicate that temperature-dependence of $$\upalpha_{\text{chironomid}-\text{H}_{2}\text{O}}$$

α

chironomid
-

H
2

O

should be considered when chironomid δ18O is used as a paleoenvironmental proxy, especially in cases where data from chironomids are combined with oxygen-isotope values from other materials for which fractionation is temperature dependent, such as calcite, in order to derive reconstructions of past water temperature.
An Evaluation of Dual Systems Theories of Adolescent Delinquency in a Normative Longitudinal Cohort Study of Youth
Authors: Murray Aja Louise , Zhu Xinxin , Mirman Jessica Hafetz , Ribeaud Denis , Eisner Manuel 
Published: April 2021

AbstractDual systems theories of adolescent risk-taking propose that the socioemotional and self-regulation systems develop at different rates, resulting in a peak in sensation-seeking in adolescence at a time when self-regulation abilities are not yet fully mature. This “developmental imbalance” between bottom-up drives for reward and top-down control is proposed to create a period of vulnerability for high-risk behaviors such as delinquency, substance use, unprotected sex, and reckless driving. In this study, data from the Swiss longitudinal normative z-proso study (n = 1522,n = 784 male; aged 11, 13, 15, 17, and 20) were used to test whether the presence of a developmental imbalance between sensation-seeking and self-regulation is associated with trajectories of engagement in delinquency across early adolescence to adulthood. Using a latent class growth analysis of sensation-seeking, self-regulation, and delinquency, it was found that a model with 3 classes was optimal in the whole sample and male sub-sample, including one class characterized by a developmental imbalance and corresponding adolescent peak in delinquency. In females, there was no evidence for a class that could be described according to the trajectories hypothesized in dual systems theory. This study’s results support the claim that a developmental imbalance may drive an adolescent increase in delinquency. However, this applies only to a small subgroup of individuals, particularly males.
New and explicit constructions of unbalanced Ramanujan bipartite graphs
Authors: Burnwal Shantanu Prasad , Sinha Kaneenika , Vidyasagar Mathukumalli 
Published: April 2021

AbstractThe objectives of this article are threefold. Firstly, we present for the first time explicit constructions of an infinite family of unbalanced Ramanujan bigraphs. Secondly, we revisit some of the known methods for constructing Ramanujan graphs and discuss the computational work required in actually implementing the various construction methods. The third goal of this article is to address the following question: can we construct a bipartite Ramanujan graph with specified degrees, but with the restriction that the edge set of this graph must be distinct from a given set of “prohibited” edges? We provide an affirmative answer in many cases, as long as the set of prohibited edges is not too large.
Evolutionary responses of a dominant plant along a successional gradient in a salt-marsh system
Authors: Chen Qingqing 
Published: April 2021

AbstractThe ecological responses of plant populations along a successional gradient have been intensively examined; however, the evolutionary responses received much less attention. Here, I explored genetic changes of key phenotypic traits of a dominant clonal plant (Elytrigia atherica) along a saltmarsh successional gradient by collecting samples along the successional gradient in the high and low marsh and growing them in a common environment (greenhouse). Additionally, to explore whether changes in traits are driven by abiotic (e.g. clay thickness) and biotic (e.g. grazing intensity) variables along the successional gradient, I measured these two variables in the field. I found that clay thickness (a proxy of total nitrogen) increased along the successional gradient both in the high and low marsh; grazing intensity from hares (the most important herbivores) decreased along the successional gradient in the high marsh but did not change in the low marsh. Meanwhile, I found that growth in number of leaves and ramets decreased, while rhizome length increased, along the successional gradient for E. atherica collected from the high marsh. Opposite trends were found for E. atherica collected from the low marsh. Results suggest that, in the high marsh, herbivores may overrule nutrients to drive trait changes. That is, at the early successional stages, E. atherica had higher growth in number of leaves and ramets to compensate for high-intensity grazing. In the low marsh, nutrients may be the dominant driver for trait changes. That is, at the late successional stages, E. atherica had higher growth in number of leaves and ramets but shorter rhizomes to maximize its expansion under the favorable conditions (higher nutrient availability). Results suggest that ecologically important abiotic and biotic variables such as nutrients and herbivores may also have a substantial evolutionary impact on plant populations.
The follow-up of the robotic-assisted Soave procedure for Hirschsprung’s disease in children
Authors: Quynh Tran Anh , Hien Pham Duy , Du Le Quang , Long Le Hoang , Tran Nguyen Thi Ngoc , Hung Tran 
Published: April 2021

AbstractRobotic surgery offers three-dimensional visualization and precision of movement that could be of great value to gastrointestinal surgeons. There were many previous reports on robotic technology in performing Soave colonic resection and pull-through for Hirschsprung’s disease in children. This study described the follow-up of the Robotic-assisted Soave procedure for Hirschsprung’s disease in children. Robotic-assisted endorectal pull-through was performed using three robotic arms and an additional 5-mm trocar. The ganglionic and aganglionic segments were initially identified by seromuscular biopsies. The rest of the procedure was carried out according to the Soave procedure. We left a short rectal seromuscular sleeve of 1.5–2 cm above the dentate line. From December 2014 to December 2017, 55 pediatric patients were operated on. Age ranged from 6 months to 10 years old (median = 24.5 months). The aganglionic segment was located in the rectum (n = 38), the sigmoid colon (n = 13), and the left colon (n = 4). The mean total operative time was 93.2 ± 35 min (ranging from 80 to 180 min). Minimal blood was lost during the surgery. During the follow-up period, 41 patients (74.6%) had 1–2 defecations per day, 12 patients (21.8%) had 3–4 defecations per day, and 2 patients (3.6%) had more than 4 defecations per day. Fecal incontinence, enterocolitis, and mild soiling occurred in three (5.4%), four (7.3%), and two pediatric patients, respectively. Robotic-assisted Soave procedure for Hirschsprung’s disease in children is a safe and effective technique. However, a skilled robotic surgical team and procedural modifications are needed.