bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the “Drugspeak” Program on Drug Name Pronunciation Skills and Perceptions in a Pharmacy Student Cohort
Authors: Cheesman Matthew J. , Do Darren , Alcorn Sean , Grant Gary , Cardell Elizabeth 
Published: November 2021

Abstract
Background: Medication errors can lead to life-threatening outcomes. Such errors can arise from the poor pronunciation of drug names, leading to the unintentional administration of incorrect medicines to patients. In our experience, students experience difficulties in pronouncing many drug names. We have devised a pilot study called DrugSpeak to provide students with the educational scaffolding required to pronounce both familiar and unfamiliar drug names correctly.Methods: A total of 26 willing student participants from a second-year Pharmacy course were provided access to online videos and audio recordings of drug names, and undertook a workshop that provided them with basic phonetics training to assist them in pronouncing drug names correctly. Students conducted audio recordings of a list of drug names at the start and end of the course, as well as surveys both before and after the intervention with the DrugSpeak Program. Results: Significant increases in student performances in terms of drug pronunciation and accuracy were observed following the DrugSpeak program. Students were strongly supportive of the DrugSpeak program in their coursework and perceived a high importance of drug pronunciation at university and in their future career paths. They also reported reductions in anxiety and improvements in their confidence levels arising from DrugSpeak in terms of their drug pronunciation proficiency levels.Conclusions: The DrugSpeak Program yielded promising outcomes in the improvement of student drug pronunciation skills, and in providing students with confidence to tackle drug names unfamiliar to them. Future studies will address the extensibility and effectiveness of the program in other health degree courses.
Computational Investigation of Thermal Decomposition Mechanism of 5-Nitro-5-R-1,3-Dioxane Compounds
Authors: Ruiz Pablo Andrés , Quijano Silvia , Quijano Jairo 
Published: November 2021

Abstract
This paper features the results of the computational study of thermal decomposition reaction of 5-nitro-5-R-1,3-dioxane compounds, with R=H, Br and CH3. Computational calculations were performed on M06-2X/6-311+G(d,p) in gas phase and also in solution with DMSO, at different temperatures. The kinetic and thermodynamic data obtained indicate a favoring of the reaction when the molecule presents a CH3 substituent group in position 5 and when carried out in DMSO, the stability of the molecules in their energetic components was discussed, too. For R=H two different reaction mechanisms were proposed and studied. Wiberg bonds indices were obtained for the reactions studied and the results were examined in terms of bond formation and bond breaking progress as well.
Development of a Core Set of Outcome Measures for Use During Treatment of Children With Idiopathic Toe Walking: A Delphi Study and Online Parent Survey
Authors: Gray Kelly , Pacey Verity , Caserta Antoni , Polt Desiree , Williams Cylie M 
Published: November 2021

Abstract
Introduction

There is diversity in outcome measures used during monitoring and treatment of the exclusionary diagnosis idiopathic toe walking (ITW) in children. This diversity makes synthesis of treatment effects difficult. The primary aim of this research was to develop a core set of outcome measures identified by health professionals for use when undertaking treatment with children who have ITW. The secondary aims were to understand if parents agreed with this core set, and if parents believed they could undertake any of these measures in the absence of the clinician.
Methods

Study 1 was the development of consensus and agreement through the modified Delphi technique with 10 expert health professionals. The first round gathered questions and assessments for consensus, the second and third round enabled agreement with these questions and assessments. Study 2 was an online survey where parents of children who toe walked were invited to provide opinions on the importance of these measures and if they believed they may be able to collect the data about their child without the health professional being present.
Results

Ten health professionals provided 21 questions and assessments in Round 1 to measure treatment effectiveness for ITW in children. Following consensus and agreement by health professionals over the three rounds, there were nine questions and assessments presented to parent participants in Study 2. There were 34 parents who provided information about their satisfaction with toe walking assessments and treatments. There 27 parents provide detailed responses about the outcome questions and assessments, most parents in support of the core set identified by the experts. Parents also expressed a willingness to self-complete questions or be taught assessments to monitor their child’s progress.
Conclusion

This research developed a core set of questions and measures clinicians, and researchers could implement during health care provision and any research of children with ITW. Use of these measures will enable consistent data collection regardless of the setting and provide the foundation for large data pooling in future treatment research.
Spectroscopic and Transport Behavior of HAB-6FDA Thermally Rearranged (TR) Nanocomposite Membranes
Authors: Patel Harsh , ACHARYA NAVEEN KUMAR 
Published: November 2021

Abstract
Nanocomposite membranes are a class of innovative filtering materials made up of nanofillers embedded in a polymeric or inorganic oxide matrix that functionalized for the membrane. Thermally rearranged (TR) polymers are found to have a good blending of selectivity and permeability. Chemical iridization is a process for used to make HAB-6FDA polyimide from 3,3 dihydroxy-4,4 diamino-biphenyl (HAB) & 2,2-bis-(3,4-dicarboxyphenyl) hexafluoro propane dianhydride (6FDA). The sample is first changed from a pure polymer membrane to a silica nanofiller doped polymer layer and explain thermally rearrangement for gas permeability in polymer nanocomposite layers and its relationship with kinetic diameter of different gases. The selectivity is decreases as the permeability increases that shows on a trade-off relationship between permeability & selectivity. The CO2 permeability of the HAB-6FDA TR polymers is greater than that of other classes of polymers by equal free volume and indicating that these TR polymers have free volume distribution that supports high permeability. Thermally rearranged polymer nanocomposite exhibits higher gas permeability than that of silica doped and pure polymer. The selectivity for H2/N2 and H2/CO2 gas pairs exceeds towards Robeson's upper bound limit and in case of H2/CH4 gas pair this limit were crossed the Robeson’s upper bond limit. UV spectroscopy shows the change in transmission at higher wavelengths, while XRD show the reduction in FWHM with thermal treatment temperature. Polymer nanocomposite can be utilized to obtain high purity hydrogen gas for refinery and petrochemical applications.
Subclinical Carotid Artery Atherosclerosis and Cognitive Function in Older Adults
Authors: Lin Felice , Pa Judy , Karim Roksana , Hodis Howard N. , Han S. Duke , Henderson Victor W. , John Jan A. St. , Mack Wendy J. 
Published: November 2021

Abstract
BackgroundThe combined effects of increased life expectancy and the considerable number of persons reaching old age will magnify the dementia epidemic in the United States. Demonstration that subclinical atherosclerosis precedes and is associated with cognitive impairment suggests a modifiable risk factor for age-associated cognitive impairment and dementia. The purpose of this study is to determine whether subclinical atherosclerosis as measured by carotid artery intima-media thickness (CIMT) is associated with changes in cognitive function over time in older adults.MethodsThis cohort study combined longitudinal data from three clinical trials conducted between 2000-2013: the B-Vitamin Atherosclerosis Intervention Trial (BVAIT), the Women’s Isoflavone Soy Health (WISH) trial, and the Early versus Late Intervention Trial with Estradiol (ELITE). Participants were recruited from the general population in the Greater Los Angeles area and were free of cardiovascular disease and diabetes; no cognitive or psychiatric exclusion criteria were specified. The same standardized protocol for ultrasound image acquisition and measurement of CIMT was used in all trials. CIMT measurements performed at baseline were used in these analyses. Cognitive function was assessed at baseline and at 2.5 years using a battery of 14 standardized cognitive tests. All clinical trials were conducted at the University of Southern California Atherosclerosis Research Unit, Los Angeles and had at least 2.5 years of cognitive follow-up.Results308 men and 1,187 women, mean age of 61 years, were included in the combined longitudinal dataset for the primary analysis. No associations were found between CIMT and cognitive function at baseline. There was a weak inverse association between CIMT at baseline and change in global cognition assessed over 2.5 years (β (SE)=-0.056 (0.278) units per 0.1 mm CIMT, SE: 0.278, 95% CI: -0.110, -0.001, p=0.045). No associations between CIMT at baseline and changes in executive function, verbal memory, or visual memory were found.ConclusionsIn this sample of healthy older adults, our findings suggest an association between subclinical atherosclerosis and change in global cognitive function over 2.5 years. Subclinical atherosclerosis of the carotid artery may be a modifiable predictor of cognitive decline in middle and older age.Trial RegistrationBVAIT (NCT00114400), WISH (NCT00118846), ELITE (NCT00114517)
Symmetrical Sporotrichosis: Self-Inoculated by Frequently Contacting Skin Lesion?
Authors: zheng Lu , Ran Xin , Pradhan Sushmita , RAN Yuping 
Published: November 2021

Abstract
An 85-years-old farmer presented with verrucous mass in the right lower leg inner side for five years, and then the left leg inner side gradually developed a similar lesion. Yeast cells were observed in the tissue with PAS and GMS. Sporothrix globose was identified by culture, ITS, and CAL. The patient improved after 4 months of oral terbinafine. The development and distribution of exceptional characteristics lesion indicated self-inoculation by the close touch of legs during sleeping resulted in symmetrical sporotrichosis.
Dual Target of EGFR and mTOR Suppress Triple Negative Breast Cancer Cell Growth Via Regulation The Phosphorylation of mTOR Downstream Proteins
Authors: Ma Jing , Li Hongtao , Cao Yanzhen , Fan Jingjing , Ma Binlin 
Published: November 2021

Abstract
Background：Triple-negative breast cancers (TNBC) are the most aggressive subtype of breast cancer, accounting for 15% - 20% of all cases, and have no response to available hormonal therapies and anti-HER2-targeted therapies due to the absence of corresponding targets. Over half of TNBC patients have overexpressed EGFR, but they are insensitive to EGFR inhibitors from monotherapy. Mammalian target of rapamycin (mTOR) connected with EGFR in the downstream signaling and involved in the progress of TNBC. The purpose of this study is to determine the combined effect of everolimus and geftinib in a TNBC cell model and investigate the possible mechanism. Results: This work showed the expression EGFR and p-mTOR protein in TNBC tissues were significantly higher than that in non-TNBC(p<0.05), while the expression of mTOR, S6K1, pEGFR and p-S6K1 were significantly higher in the EGF stimulation. EGFR and p-mTOR protein are related to poor prognosis. EGFR inhibitor gefitinib and mTOR inhibitor everolimus significantly inhibited the proliferation of human triple-negative breast cancer MDA-MB-468 cells and arrested cells in G0/G1 phase when applied separately and in combination in a dose-dependent manner (P<0.05). Meanwhile, the rate of apoptosis of MDA-MB-468 cells was significantly incresased separately by two drugs (P<0.01). Furthermore, the combination of everolimus and geftinib reduced the phosphorylation of mTOR downstream proteins. Instead, the phosphorylation of 4E-BP1 was enhanced after the everolimus and geftinib treatment, indicated an alternative activation pattern. Conclusions: These results suggested that dual inhibition of mTOR and EGFR could be a promising approach to treat TNBC.
Jujuboside A Attenuates Sepsis-Induced Cardiomyopathy By Inhibiting Inflammation and Regulating Autophagy
Authors: Wang Zi , Ji Qingqi , Li Yanjie , Cai Zhaohua , Fang Liang , Huo Huanhuan , Zhou Guo , Yan Xiangming , Shen Linghong , He Ben 
Published: November 2021

Abstract
Background: Jujuboside A (JuA), as a main effective component of Jujubogenin, which was extracted from the seed of Ziziphus jujuba Mill, has long been known as a sedative-hypnotic drug. The aim of the current study was to investigate the potential effect of JuA on sepsis-induced cardiomyopathy (SIC) induced by lipopolysaccharide (LPS) in mouse models. Method: Wide type C57BL/6J mice were randomly divided into four groups: ddH2O+control, ddH2O+JuA, LPS+NS and LPS +JuA, and the cardiac function of septic mice were detected by echocardiography. Moreover, the survival rate at each time point was calculated for 7 days. ELISA assays were used to analyze inflammatory factors in serum. Furthermore, Western blotting, flow cytometry and TUNEL staining were performed to assess cell apoptosis and transmission electron microscopy detecting the number of autophagosomes. Finally, the expression of autophagy-related and oxidative stress-related proteins was analyzed by western blotting and immunohistochemistry staining. Results: Results showed that JuA pretreatment significantly improved the survival rate and cardiac function, and suppressed systemic inflammatory response in septic mice. Further study revealed that JuA could decrease cell apoptosis and enhanced autophagy. Moreover, JuA pretreatment also significantly decreased oxidative stress and nitrodative stress, as evidenced by downregulating iNOS and gp91 expression in vivo. In addition, the autophagy inhibitor 3‑MA significantly abolished the effect of JuA on autophagic activity in SIC. Conclusion: In conclusion, the findings indicated that JuA enhanced autophagy blocking inflammasome-mediated cardiomyocyte apoptosis and suppress myocardial iNOS and gp91 expression to improve cardiac function of SIC in septic mice.
Can sarcopenia index serve as a predictor of myocarditis from mRNA based COVID-19 vaccine, insights from clustered cases and potential involvement of micro-RNAs in its pathogenesis.
Authors: AbdelMassih Antoine , Shershaby Meryam El , Gaber Hanya , Ismail Habiba-Allah , El-Hussseiny Nadine , Amin Abeer , ElBoraie Aly , Ayad Aya , Menshawey Esraa , Sefein Fady , Osman Ibrahim , Moursi Mai , Hanafy Maram , AbdelAziz Mariam , Arsanyous Mariem , Khaled-Ibn-El-Walid Mariam , Tawfik Marwa , Habib Menna , Mansour Mina , Ashraf Mirette , Khattab Mohamed , AlShehry Nada , Hafez Nada , ElDeeb Naheel Essam , Ashraf Nirvana , Khalil Noha , AbdElSalam Noheir , Shebl Noura , Hafez Nouran , Youssef Nourhan , Bahnan Odette , Ismail Passant , Kelada Peter , Menshawey Rahma , Saeed Rana , Husseiny Reem , Yasser Reem , Sharaf Safa , Adel Veronia , Naeem Youstina , Nicola Youstina , Kamel Aya , Hozaien Rafeef , Fouda Raghda 
Published: November 2021

Abstract
Background: With the current mass international roll out of several vaccines against SARS-Cov-2, several reports of unheeded complications have made headlines. One of which involves myocarditis with the now FDA fully approved vaccine, Pfizer, and others. We hypothesize through this study that a dysregulated micro-RNA response resulting from such type of vaccines can be involved in triggering myocarditis. Methodology: Embase, Medline and the Cochrane Central Register were used to search for specific keywords such as “mRNA COVID-19 vaccines” AND “Myocarditis” for relevant publications up to 1st of September 2021. The systematic review was performed using PRISMA protocolResults:Literature review has identified 26 cases series and reports involving the development of myocarditis from mRNA vaccines, a total of 89 patients were included. Age range was clearly identified in 66 patients. Among those 66 patients, 94% were below 50 years of age, also out of 89 patients, 94% were males. Myocarditis developed, after a median time of 72 hours of the 2nd dose. 90 of cases of myocarditis developed myocarditis after the 2nd dose, the few patients developing myocarditis after the first dose were either predisposed by a history of myocarditis or a history of previous COVID-19 infection. Conclusion:In conclusion, interpretation of the results in view of the suggested hypothesis, reveals that the micro-RNAs implicated in myocarditis in general are as well implicated in the pathogenesis of severe COVID-19, this can explain why patients having a first dose with a history of COVID-19 can develop myocarditis from mRNA vaccines, also the relatively higher likelihood of this complication in males and younger aged individuals can be explained by the upregulation of key myocarditis related miRNAs in those two strata, due to higher muscle mass and suggests performing a sarcopenia index in recipients of the vaccine to correlate it with the likelihood of this complication. This could later set a cut-off of this easy bed-side index to stratify cases a higher risk of this rare complication.
Sublobectomy versus lobectomy for postoperative cough-related quality of life and recovery in early-stage non-small cell lung cancer patients: a longitudinal study.
Authors: Lin Rongjia , CHEN Wen , ZHU Leilei , PAN Xiaojie 
Published: November 2021

Abstract
Background

To quantitatively evaluate postoperative cough regarding changes in health-related quality of life (HRQOL) and recovery trajectory with the Leicester Cough Questionnaire in Mandarin-Chinese (LCQ-MC) in patients undergoing video-assisted thoracic surgery (VATS) for early-stage non-small cell lung cancer (NSCLC).
Methods

Overall, 156 patients with NSCLC underwent either VATS lobectomy or VATS sublobectomy; LCQ-MC was used to report the impact of postoperative cough on HRQOL for 6 months after discharge. Recovery from postoperative cough was defined as LCQ-MC scores returning to preoperative levels. The sensitivity of LCQ-MC to changes in postoperative cough recovery over time was evaluated via its ability to distinguish between surgery types.
Results

The VATS sublobectomy group reported significantly higher mean LCQ-MC scores 1 month after discharge, but without no significant differences postoperatively at 3 and 6 months after discharge, and returned to preoperative physical (69 vs. 99 days), psychological (67 vs. 99 days), social (50 vs. 98 days) and total (69 vs. 99 days) scores faster than the VATS lobectomy group (all p <0.05).
Conclusion

The LCQ-MC can adequately assess the impact of postoperative cough on HRQOL. Routine monitoring of postoperative cough recovery through LCQ-MC scores could be added to enhanced recovery after surgery.
Analysis of Wavelength Sensitivity of Coupling Coefficients and Inter-core Crosstalk in a 9 core Multi-core Fiber
Authors: Hossain Afzal , Majumder Satya Prasad 
Published: November 2021

Abstract
Wavelength dependence of coupling coefficients and inter-core crosstalk in a 9-core homogeneous multi-core optical fiber (MCF) are investigated analytically. The analysis is further extended to evaluate the mean crosstalk power at the output of any core with light launched into other core of the MCF. Propagation length dependence of mean crosstalk power is investigated using both coupled mode theory (CMT) and coupled power theory (CPT). CPT based results show that mean crosstalk power linearly dependent on propagation distance, and it is higher for higher values of coupling coefficient. On the other hand, the mean crosstalk power is found to oscillate with the propagation distance in case of CMT. It is also observed that the mean crosstalk power (dB) is more prominent at a lower wavelength for a given propagation distance. The behavour of relative crosstalk power is also investigated analytically where it is noticed that the relative crosstalk power increases almost linearly with core pitch and with wavelength. It is also seen that the relative crosstalk power (dB) is more in an MCF with lower number of cores when it is varied with respect to wavelength. This is due to the increase of core pitch under the same cladding diameter and cladding thickness limitations.
BCOR-CCNB3 Sarcoma with Concurrent RNF213-SLC26A11 Gene Fusion: A Rare Sarcoma with Altered Histopathological Features After Chemotherapy
Authors: Huang Wen , Wang Wei , Huang Liang-Liang , Li Heng , Zhou Wen-Chao , Wu Hai-Bo 
Published: November 2021

Abstract
Background Chemotherapy is a common approach for cancer treatment, but intrinsic genetic mutations in different individuals may cause different responses to chemotherapy, resulting in unique histopathological changes. The genetic mutation along with the distinct histopathological features may indicate new tumor entities. BCOR-CCNB3 sarcomas are a kind of Ewing-like sarcomas (ELS) occurring mostly in bone and soft tissues. No gene fusion other than BCOR-CCNB3 has been found in this type of tumor. Case presentation Here, we report a case of 17-year-old male patient presented with a mass on his left shoulder that was diagnosed as undifferentiated small round cell sarcoma according to core biopsy. The patient received 5 courses of pre-operational chemotherapy, and the tumor was resected and analyzed. We observed primitive small round cells and larger myoid cells in the resected tumor tissue but not in biopsy, arterioles stenosis and occlusion were also detected, indicating a dramatic change of histopathological features of this tumor. In addition, the immunohistochemical results showed the altered staining patterns of BCOR, bcl2, CyclinD1, TLE1, AR, SMA, CD117, STAB2, CD56 and CD99 in tumor tissues after chemotherapy. Importantly, RNA sequencing revealed a RNF213-SLC26A11 fusion in the tumor sample. Conclusions We propose that the BCOR-CCNB3 sarcoma with RNF213-SLC26A11 fusion may indicate a subset of tumors that undergo histopathological changes in response to chemotherapy. More similar cases in the future may help to clarify the clinical meanings of RNF213-SLC26A11 fusion in BCOR-CCNB3 sarcomas and the underlying mechanisms.