bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the contribution of the unfolded protein response to prostate cancer bone metastasis
Authors: Kaya Zeynep 
Published: November 2021

Zeynep Kaya, John C. Christianson, Ian G. Mills, Srinivasa R. Rao, Claire M. Edwards

The majority of deaths from PCa arise following metastasis, particularly to the skeleton. ER stress and the unfolded protein response (UPR) promote primary PCa, however the contribution of the UPR to PCa bone metastasis remains unknown. The aim of this work was to determine the role of the UPR in PCa bone metastasis, focusing on the osteogenic potential of PCa cells, EMT and migration, and PCa-induced bone disease. Using paired cell lines ARCaPE and ARCaPM which differ in their epithelial (E) and mesenchymal (M) characteristics, we found that components of IRE1 and ATF6 pathways are higher in ARCaPE cells than in ARCaPM and decreased upon osteogenic differentiation of ARCaPM cells. Inhibition of the IRE1 or PERK pathway increased ALP activity in ARCaPM cells. Inhibition of specific arms of the UPR produced a varied response in EMT markers with no effect on migration of ARCaPM cells. Increasing ER stress using tunicamycin significantly reduced migration of ARCaPM cells. The bone disease associated with PCa bone metastases is driven by alterations in a complex signaling network, including the RANKL/OPG pathway and Wnt signaling. ER stress, induced by tunicamycin, decreased RANKL and Dkk1 expression and increased OPG expression in ARCaPM cells. This osteolytic response to ER stress was blocked by PERK inhibition. Taken together, my research demonstrates that the UPR has multiple effects in bone metastatic PCa cells, including a reduction in migration and in osteolytic factors following UPR activation, suggesting a novel mechanism by which the UPR may modulate PCa-induced bone disease.
Molecular and proteomic signatures associated with preservation related graft injury: insight from human liver normothermic achine perfusion (NMP)
Authors: Dengu Fungai 
Published: November 2021

Fungai Dengu1; Sadr Shaheed1; Letizia Lo Faro1; Adam Thorne1; Honglei Huang1; Peter Friend1,Rutger Ploeg1.
1. Oxford Organ Perfusion Lab, Nuffield Department of Surgical Sciences and Oxford BiomedicalResearch Centre, University of Oxford, Oxford, UK
BackgroundContinuous liver NMP is a novel technology associated with safe extension of organpreservation time, increased organ utilisation and reduced early graft injury1. Increasingly, it isutilised as a ‘back to base’ application with cold storage for organ transport and NMP initiatedat the implanting centre prior to transplantation2. We aimed to evaluate the impact ofadditional cold ischaemia time (CIT) on the proteomic and molecular signature of NMP livers.
MethodsLiver tissue samples (N= 57) from a prospective clinical trial of ‘back to base’ NMP wereanalysed. Collection occurred at the end of cold storage (LT1), end of NMP/total preservation(LT2) and after organ reperfusion (LT3). Unbiased, label-free-quantitative (LFQ) proteomicanalysis was conducted using liquid chromatography with tandem mass spectrometry andtrapped ion mobility spectrometry (TIMS) to time-of-flight (TOF) mass analysis (LC-MS/MS TIMSTOF).Differential expression and Gene Ontology/Pathway analysis were performed.
ResultsLT2 samples with prolonged CIT (>6hr) prior to NMP had significant differential expression ofproteins associated with liver-specific oxidative stress, cellular haemostasis and removal ofdamaged or misfolded proteins (e.g. CYP3A5, PSMB1). LT3 samples, similarly, had reducedproteins involved in autophagy and cell-cycle regulation (e.g. STBD1, CD2AP, GADD45GIP1,) andincreased expression of proteins involved in neutrophil chemotaxis, adhesion and aggregation(e.g. S100A9).
DiscussionThe molecular signature of grafts at LT2 and LT3 varies depending on the length of CIT prior toNMP. Further exploration of the molecular signatures associated with preservation related graftinjury is required to determine how best to apply this novel technology clinically.

References:1. Nasralla, D. et al. A randomized trial of normothermic preservation in livertransplantation. Nature 557, 50–56 (2018).2. Ceresa, C. D. L. et al. Transient Cold Storage Prior to Normothermic Liver Perfusion MayFacilitate Adoption of a Novel Technology. Liver Transplant. lt.25584 (2019).doi:10.1002/lt.25584
Politique de la fatigue
Authors: Huët Romain 
Published: November 2021

La fatigue se manifeste par une perte de vitalité. Mais elle est surtout une expérience du gouffre. Elle est le sentiment que les attachements familiaux, amicaux ou plus largement à l’humanité se défont au point de n’apparaître que comme froids, superficiels et sans reliefs. L’expérience de la Covid-19 a étendu à toujours plus de personnes ce sentiment d’épuisement face à un monde étroit et drastiquement verrouillé. Dans cet article, l’intention est de ne prendre que quelques aspects de cet état d’épuisement : sa signification politique, d’une part, et la façon d’y répondre collectivement, d’autre part.
Dissuasion française : de « Neuf jours à Lyon » à « Sept jours au Rhin »
Authors: Audrand Stéphane 
Published: November 2021

L’étude des planifications opérationnelles soviétiques de 1964 et 1979 montre l’évolution de la dissuasion nucléaire française et la montée en puissance de sa crédibilité. C’était la traduction de l’effort consenti par la France pour assurer sa souveraineté et protéger ses intérêts vitaux dans le contexte de la guerre froide.
P16INK4a/ki67 Immunocytochemistry in Improving the Predictive Value for High Grade Cervical Intraepithelial (≥CIN2) Neoplasia in Pap Smear
Authors: Kumar G Vinoth , Prabhu Anne Jennifer , Sebastian Ajit , Raghavendran  , Abraham Priya , Peedicayil Abraham 
Published: November 2021

Introduction:
Cervical cytology has limited sensitivity to detect cervical pre-cancerous lesions. High-risk human papillomavirus (hr-HPV) DNA testing has high sensitivity but its specificity is limited. This study was done to assess the utility of p16INK4a/ki-67 dual stained cytology in improving the predictive value for high-grade cervical (CIN2+) lesions.

Aim/Objective:
To assess the significance of P16/Ki-67 immunocytochemistry in improving the predictive value for high-grade cervical intraepithelial (≥CIN 2+) lesions on Pap smear.

Material and Methods:
This was a prospective diagnostic study that included 93 patients with ASC-US/LSIL/ASC-H and HSIL on thin prep cervical smears and who also underwent hr-HPV DNA test and colposcopy-guided biopsy. Biopsy was the gold standard against which the performance of P16INK4a/Ki-67 and hr-HPV results were compared.

Results:
In women of all ages, sensitivity of (96.8%) hr-HPV test and p16/Ki-67 dual immunocytochemistry (≥1 positive cell) were similar and negative predictive value (NPV) was (97.1% vs. 97.9%) but the latter test showed better specificity (69.4% vs. 53.2%) and positive predictive value (PPV, 61.2% vs. 50.8%) for ≥CIN 2 lesions. A higher cut off of at least 10 positive cells gives a higher specificity and PPV, with slightly decreased sensitivity and NPV.

Conclusion:
Because high-risk HPV test has a high sensitivity and NPV, whereas P16/Ki-67 dual immunocytochemistry (≥10 positive cells) has a high specificity and PPV, the latter can be recommended as an ancillary test in hr-HPV-positive women to reduce the number of women going for colposcopy and biopsies.
Brain perfusion single-photon emission computerized tomography/computerized tomography: Stroke-like manifestations of COVID-19 with transient antiphospholipid elevation
Authors: Chun Kwang , Zamora Edgar , Coco Maria 
Published: November 2021

AbstractCOVID-19 is a viral respiratory disease associated with neurologic complications such as encephalitis or stroke in a minority of patients. The wide variety of neurologic manifestations with often unclear etiology may confound diagnosis and management. We present a young man admitted following an 8-day onset of self-resolving episodes of left hemiplegia and hemifacial droop. Diagnostic work up for seizures and stroke was largely negative. “Intra-ictal” ECD-single-photon emission computerized tomography/computerized tomography was consistent with right middle cerebral artery ischemia. Subsequent diagnostic work up revealed positive COVID-19 screening and newly-elevated antiphospholipid antibodies. Antiepileptic medications were discontinued, and the patient was successfully treated as an outpatient with corticosteroids leading to resolution of symptoms.
Zur Struktur und Funktion von Synonymen
Authors: Zorman Marina 
Published: November 2021

Der Artikel behandelt die Synonyme im Licht der funktionell-strukturellen Sprachtheorie Coserius. 1 Die Wahl der theoretischen Grundsätze wurde durch die Festellung diktiert, daß die bisherigen Erkenntnisse über die Synonymie widersprüchlich sind und daß auch schon über alle Feststellungen berechtigte Einsprüche erhoben wurden. Deshalb wird in dieser Arbeit auf der genannten theoretischen Grundlage, die verschiedene Gesichtspunkte des Problems verbindet, anstatt sie zu trennen (s. Punkt 2), ein Modell für die Analyse von Synonymen vorgestellt (3), das die klassischen Schwächen der Semantikforschung (zu geringe Menge tatsächlicher Daten, Subjektivität und Introspektion) durch eine empirische Untersuchung in einem Textkorpus zu ersetzen versucht. In die Analyse sind drei Inhaltsebenen einbezogen (Bezeichnung, Bedeutung und Sinn) und ihnen sind jeweils entsprechende Untersuchungsmethoden zugeordnet. Im Sinne des Modells wurden in der Arbeit Zorman 1997 zwei slowenische Synonympaare (kuverta - ovojnica und borba - boj) analysiert, die als Beispiele reiner (und totaler) Synonymie gelten können. Die Analyse wird aus Platzgründen an dieser Stelle nicht detailliert dargestellt,2 veranschaulicht werden nur ihre Tragweite und die Ergebnisse (4). Im letzten Teil (5) werden die Leistungen der vorgeschlagenen Methode bewertet und einige Annahmen dargestellt, die der weiteren Erforschung der Synonyme dienen könnten. Die objektive Behandlung der Synonymie unter unterschiedlichen Gesichtspunkten scheint einige Dogmen über Synonyme in Frage zu stellen.
Contributo alla conoscenza dei latinismi e romanismi antichi in sloveno
Authors: Šega Agata 
Published: November 2021

Romanizzazione, continuità e contatti linguistici slavo-romanzi sul territorio orientate delle Alpi e nell'area nordadriatica nel periodo paleoslavoIl fatto che il territorio dell'odiema Slovenia, soprattutto occidentale, rimanesse popolato dagli autoctoni di origine romanza ancora parecchio tempo dopo l'arrivo degli slavi è ormai indiscutibile. Quanti fossero, come suonasse il latino che parlavano, quando si assimilassero, in che ambiti della cultura materiale e spirituale si sentisse il loro influsso, sono invece questioni molto più complesse alle quali fino ai nostri giorni non si è potuto dare una risposta soddisfacente. Questo problema viene trattato da diverse scienze storiche e dalle loro discipline ausiliari: la storia con la storia del cristianesimo, I'archeologia con I'epigrafia e I'etnologia.
Développement de la technologie des fonds de sauces en utilisant les coproduits issus de la production du Kilishi
Authors: Tiendrebeogo Stéphanie C.W. , Kabore Donatien , Tankoano Abel , Pare Adama , Hama-Ba Fatoumata , Douamba Amanda T.J.A. , Dicko Mamoudou H. , Sawadogo-Lingani Hagrétou 
Published: November 2021

Le glutamate industriel (glutamate monosodique) représente à l’heure actuelle l’un des exhausteurs de goût les plus produits et consommés dans le monde. Cependant face à la menace de cet additif de synthèse sur la santé des consommateurs, des exhausteurs de goût d’origines naturelles sont de plus en plus recherchés dans notre alimentation. L’objectif de la présente étude est de produire des exhausteurs de goût d’origine naturelle à partir des coproduits issus de la production du Kilishi tels que les os, les parures de viande, des épices et ingrédients. Dans cette étude deux formulations de fonds de sauce concentrés de types Kilishi et deux formulations de fonds de sauce séchés ont été produits. Les qualités microbiologiques, nutritionnelles et sensorielles des fonds ont été évalués. Les résultats des analyses ont montré que les fonds de sauces concentrés de type Kilishi étaient de bonnes qualités nutritionnelles, microbiologiques, sensorielles, se conservaient bien à température ambiante et amélioreraient les goûts des saucisses. Par contre, les résultats des analyses microbiologiques ont montré que les fonds de sauces séchés n’étaient pas de bonne qualité microbiologique. La présente étude est une contribution à la diversification des exhausteurs de goût d’origine naturelle.

English title: Development of sauce base technology using co-products from the Kilishi production
Industrial glutamate is currently one of the most widely produced and consumed flavor enhancers in the world. But faced with the threat of this synthetic additive on health of consumers, flavor enhancers of natural origin are increasingly sought after in our food. The aim of the present study was to produce non-synthetic broths used as flavor enhancers (sauces bases) from the co-products from Kilishi production such as bones, meat trimmings, spices and ingredients. In this study two formulations of concentrated sauce bases and dried sauces bases Kilishi -types were produced. The microbiological, nutritional and sensory qualities of different formulations of sauces bases were evaluated according to the respective standards methods. The results showed that the concentrated sauce bases of the Kilishi type were of good nutritional, microbiological and sensory qualities and kept well at room temperature. However, the results from microbiological analyzes showed that the dried sauce bases Kilishi- types were not of good microbiological quality. This study is a contribution to the diversification of natural flavor enhancers.
Edukasi Perilaku Hidup Bersih Dan Sehat (PHBS) Pada Anak-Anak di Kampung Pemekaran Mister Ngiosi Manokwari Pada Masa Pandemi Covid-19
Authors: Kawulur Elda Irma Jeanne Joice , Sinuraya Sabarita , Dwiranti Febriza , Panjaitan Rawati , Ratnawati Sita 
Published: November 2021

Clean and Healthy Lifestyle (PHBS) are all health behaviors that are carried out with awareness so that family or family members can help themselves in the health sector and play an active role in health activities in the community. This community service program is motivated by limited access to information, transportation and health in rural areas of Kampung Pemekaran Mister Ngiosi Manokwari causing a lack of understanding and application of a clean and healthy lifestyle by children, especially during the Covid-19 pandemic. To overcome this gap, it is necessary to disseminate information about clean and healthy living behavior in children. Activities on PHBS are using interactive learning in the form of lectures and giving some questions related to the PHBS and reward, demonstration related to preventing the transmission of Covid-19. The results of the activity showed that about 80% of the children could carry out 11 steps of hand washing activity well. In terms of healthy food, 100% of the children finished the given food.
SCHOOL ADMINISTRATORS’ AND TEACHERS’ VIEWS ABOUT THE USE OF SOCIAL MEDIA AT SCHOOLS AS A NEW PLATFORM IN ORGANIZATIONAL COMMUNICATION
Authors: Doğan Emine , Çevik Mehmet Sabir 
Published: November 2021

<p>This research aimed to evaluate the school administrators’ and teachers’ views about the use of social media at schools as a new platform in organizational communication. Phenomenology, a qualitative research model, was used in the research. A total of 17 participants who were included in the research (school administrators and teachers) were selected by using the purposive sampling methods that were well-suited to the qualitative research studies, namely, the “maximum variation sampling method” and the “criterion sampling method”. Participants’ views were received via semi-structured and in-depth interviews. The research data were analyzed by using the NVivo 12.0 software. The inductive descriptive analysis, content analysis, and the constant comparison technique were utilized in the interpretation of interview texts. In this context, the participants’ views were grouped under the themes of “views about the definition of social media”, “views about whether the use of social media at schools is necessary”, “views about the purpose of using social media at schools”, “views about the likely effects of using social media at schools”, and “views about recommending the use of social media at schools”. In the research, the participants stated that they viewed social media as a communication tool, the use of social media at schools was necessary, social media platforms could be used for education &amp; instruction and giving (sharing) information, social media could have positive effects besides negative effects, and certain societal, technical, and legal measures should be taken to assure that the social media was used effectively. To ensure the professional use of social media at schools, it is recommended that educators undergo professional development.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0987/a.php" alt="Hit counter" /></p>
THE DUAL ROLE OF STUDENTS PURSUING A HIGHER DEGREE AND PROVIDING CARE TO THEIR CHILDREN AND FAMILY MEMBERS DURING THE COVID-19 PANDEMIC
Authors: Avorgbedor Forgive , Velime Helene 
Published: November 2021

<p>The objective of this qualitative study was to explore the psychological well-being of college students during the COVID-19 pandemic and highlight their experience as caregivers. A total of 1444 college students responded to the questionnaire on the impact of COVID-19 on their lives. Qualitative responses from 25 female and 7 male college students who serve as caregivers were analyzed. Data were assessed using thematic analyses. The analysis revealed that college students’ caregiving experiences impacted every aspect of their lives, including psychological health, academic performance, and career. Students who served as caregivers indicated that the mandated "Stay-at-Home" order resulted in homeschooling children, working from home, and attending school via online at home, limiting space for work, school, childcare, and homeschool. This led to increased stress, difficulty finding childcare, a drop in GPA for some, fear of delayed graduation, and financial distress. Conclusion: University students serving as caregivers were negatively affected during the pandemic. These individuals play a significant role in the workforce; therefore, rethinking resources and policies promoting their success as they serve their loved ones is in society's best interest.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0754/a.php" alt="Hit counter" /></p>
Waqf Blockchain in Indonesia
Authors: Mutmainah Lu'liyatul , Nurwahidin  , Huda Nurul 
Published: November 2021

Abstract: The emergence of innovation in the world of digital finance in recent years has received attention from various parties commonly known as financial technology. This innovation is in the form of crowdfunding and blockchain platforms. These two innovations can not only be used for commercial, but also social purposes, including waqf. There is a huge potential of cash waqf in Indonesia. However, the realization is relatively still low. This study aims to analyze at a glance waqf blockchain in Indonesia that can optimize the realization of waqf development in Indonesia. Qualitative research methods is used in this paper through the study of literature. The results of the study show that Indonesia is very likely to implement waqf blockchain because the Muslim population reaching more than 80%, the flexible concept of waqf fiqh and the emergence of the halal industry. The most challenges faced are related to waqf literacy to increase public awareness. Investigating about perceived intention to use waqf blockchain through questionnaire and a deep interview with the stakeholders is important for the future research.
Keywords: technology, blockchain, waqf.
INFLUENCE OF SOCIAL BELIEF AND WOMEN PARTICIPATION IN PUBLIC ADMINISTRATION POSITION
Authors: Mutuma Seifu 
Published: November 2021

Purpose: Globally, effective political engagement requires candid communication between the government and its citizens. More so, citizens have the right to express how they need to be governed. On government’s part, the need to develop trust among the public should be paramount. Government should always inform citizens what it is continually doing. Furthermore, public domains ought to reflect integrity and transparency. Such is achievable through communication on many of its activities. In the recent past, government utilized traditional media to convey information to the public. Popular avenues used included television, newspapers and radio. The general objective of the study was to establish the role of social media on community mobilization
Methodology: The paper used a desk study review methodology where relevant empirical literature was reviewed to identify main themes and to extract knowledge gaps.
Findings: The study found out that the adoption of social media as a means of communication between the government official’s community members has an enormous impact on community mobilization for security matters and other issues. Social media platforms have enabled quick sharing of information on Barraza. The social media platforms enable this community mobilization in a cost-efficient manner Although social media use offers enormous value in public relations, there is little evidence that social networking sites are used to inform and involve governmental public opinion agencies such as the public sector.
Recommendations: The study recommends that public administrators to embrace social media platforms such as Facebook, Twitter and WhatsApp due to their responsiveness and lower costs in interacting with the public administrators and amongst themselves. The respective government agencies should create awareness among the public on the importance of using digital platforms to pass or receive information on security issues
Effect of Time of Day on the Magnitude of Stature Change Response Variability in Participants with Chronic Low Back Pain on Consecutive 2 Days
Authors: Saiklang Pongsatorn , Puntumetakul Rungthip , Siritaratiwat Wantana , Boucaut Rose 
Published: November 2021

Measurements of stature change have been used to compare spinal loading in the sitting posture. However, it is difficult to interpret whether the stature change response recorded is truly due to an intervention or to the natural fluctuation of stature change response between the days. The aim of this study was to investigate the effect of time of day (morning and afternoon) on the variability of stature change in participants with chronic low back pain (CLBP) on 2 consecutive days. Forty-four participants with CLBP attended 2 sessions (morning and afternoon) of stature change testing on 4 separate days. A stature change response of more than 0.985 mm in the morning and 1.149 mm in the afternoon on 2 consecutive days indicates that an intervention itself has influenced stature change measurement in CLBP participants. The magnitude of stature change response on different days and times of day established specific levels of natural variation meaning changes above these levels can be attributed to intervention effects in participants with CLBP.
HIGHLIGHTS

The findings suggest that it is important to control the time at which stature change investigations are conducted
Seated stadiometry measurement, changes above 0.985 mm (morning) and 1.149 mm (afternoon) can be attributed to intervention effects between consecutive 2 days
The results of the current study presented no significant difference in magnitude of stature change response in the morning versus the afternoon in chronic low back pain participants

GRAPHICAL ABSTRACT