bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selected ‘Starter Kit’ energy system modelling data for Philippines (#CCG)
Authors: Allington Lucy , Cannone Carla , Pappis Ioannis , Barron Karla Cervantes , Usher Will , Pye Steve , Brown Edward , Howells Mark , Niet Taco , Walker Miriam Zachau , Ahsan Aniq , Charbonnier Flora , Halloran Claire , Hirmer Stephanie , Taliotis Constantinos , Sundin Caroline , Sridha Vignesh , Ramos Eunice , Brinkerink Maarten , Deane Paul , Gritsevskyi Andrii , Moura Gustavo , Wogan David , Barcelona Edito , Rogner Holger 
Published: July 2021

Abstract
Energy system modelling can be used to assess the implications of different scenarios and support improved policymaking. However, access to data is often a barrier to energy system modelling, causing delays. Therefore, this article provides data that can be used to create a simple zero order energy system model for Philippines, which can act as a starting point for further model development and scenario analysis. The data are collected entirely from publicly available and accessible sources, including the websites and databases of international organizations, journal articles, and existing modelling studies. This means that the dataset can be easily updated based on the latest available information or more detailed and accurate local data. These data were also used to calibrate a simple energy system model using the Open Source Energy Modelling System (OSeMOSYS) and three stylized scenarios (Fossil Future, Least Cost and Net Zero by 2050) for 2020–2050. The assumptions used and results of these scenarios are presented in the appendix as an illustrative example of what can be done with these data. This simple model can be adapted and further developed by in-country analysts and academics, providing a platform for future work.
A face-machine interface utilizing EEG artifacts from a neuroheadset for simulated wheelchair control
Authors: Saichoo Theerat , Boonbrahm Poonpong , Punsawad Yunyong 
Published: July 2021

Abstract
Many people suffer from movement disabilities and would benefit from an assistive mobility device with practical control. This paper demonstrates a face-machine interface system that uses motion artifacts from electroencephalogram (EEG) signals for mobility enhancement in people with quadriplegia. We employed an Emotiv EPOC X neuroheadset to acquire EEG signals. With the proposed system, we verified the preprocessing approach, feature extraction algorithms, and control modalities. Incorporating eye winks and jaw movements, an average accuracy of 96.9% across four commands was achieved. Moreover, the online control results of a simulated power wheelchair showed high efficiency based on the time condition. The combination of winking and jaw chewing results in a steering time on the same order of magnitude as that of joystick-based control, but still about twice as long. We will further improve the efficiency and implement the proposed face-machine interface system for a real-power wheelchair.
Effect of Surfactant Chain Length on Emulsification Dynamics of Self
Emulsifying Formulation of Poorly Soluble Drug
Authors: Chouhan Shailendra , Chauhan Lalit Singh 
Published: July 2021

Aim:
In this work, the aim was to study the effect of the chain length of surfactant on
the self emulsifying system of a poorly soluble drug, aceclofenac. The selection of almond oil as a
lipid vehicle was done on the basis of solubility and compatibility of the vehicle with the drug.

Methods:
The effect of varying chain length of different surfactants of Tween series, namely
Tween 20, Tween 40, Tween 60 and Tween 80, was evaluated on self emulsifying efficiency by
constructing the pseudoternary diagrams. PEG-400 was used as a co-surfactant in a definite ratio
with all the surfactants to minimize their concentration. The best self emulsifying ability was exhibited
by Tween 80: PEG-400 combination followed by Tween 60: PEG-400, Tween 40:
PEG-400, Tween 20: PEG-400. This observation indicates that as the chain length of Tweens increases,
their ability to form a good microemulsion increases if the same co-surfactant is used.

Results:
However, it has also been found that the presence of unsaturated bond in Tween 80 provides
it an elasticity which supports good intermixing of oil and water, leading to formation of a
fine microemulsion. Six different formulations were prepared using a combination of almond oil,
Tween 80, PEG-400 and the drug aceclofenac.

Conclusion:
The formulations were subjected to various evaluation parameters, such as dispersibility,
transmittance, pH, globule size, polydispersibility, zeta potential, viscosity, refractive index
and in vitro dissolution. The best formulation was found to have globule size of less than 100 nm
and zeta potential of -3.35 ± 0.60 mV, indicating the formation of a microemulsion of aceclofenac
with good stability.
Exploring the COVID-19 Potential Targets: Big Challenges to Quest Specific Treatment
Authors: Roy Harekrishna , Gummadi Asha , Nayak Bhabani Shankar , Nandi Sisir , Saxena Anil Kumar 
Published: July 2021

Background:
The novel strain SARS-CoV-2 of coronavirus diseases (COVID-19) became
pandemic at the end of 2019 with an unprecedented global crisis by infecting around 11 million people
in more than 200 countries. The condition has now been provoked by the demand, supply, and
liquidity shocks that COVID-19 has attacked the lives of a vast population.

Objective:
Researchers are therefore trying to encode and understand the viral genome sequence
along with various potential targets to explore the transmission mechanism and the mode of treatment
for COVID-19. The important structural proteins such as nucleocapsid protein (N), membrane protein
(M), an envelope protein (E), and spike protein (S) related to COVID-19 are discussed in this manuscript.

Methods:
The topology of these various targets has been explored utilizing structure-based design
and crystallographic studies.

Results:
The literature reported that the N-protein processes the viral genome to the host cell during
replication. The “N-terminal domain” and “C-terminal domain” contribute towards localization in the
endoplasmic region and dimerization respectively. The M protein determines the shape of coronavirus
and also assists the S protein to integrate with the Golgi-endoplasmic region complex leading to the
stabilization of the virion. The smallest hydrophobic viroporin termed “E” takes part in morphogenesis
and pathogenesis during intracellular infection. The viral spike (S) protein attaches the cellular
receptors and initiates virus-cell membrane fusions. The main protease in the proteolytic process during
viral gene expression and replication has also been discussed.

Conclusion:
Currently, there is no permanent cure and treatment of COVID-19 hence researchers are
repurposing a suitable combination of drugs including antiviral, antimalarial, antiparasitic, and antibacterial,
hypertensive receptor blockers, immunosuppressants, anti-arthritis drugs, including ayurvedic
formulations. In brief, it is justified that, for complete recovery, there is a need for deep and elaborate
studies on genomic sequences and invading mechanisms in the host cell.
COVID-19: Are Experimental Drugs a Cure or Cause?
Authors: Karahalil Bensu , Elkama Aylin 
Published: July 2021

Background:
Coronavirus disease 2019 (COVID-19) is a new strain of coronavirus. It is
characterized by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has quickly influenced
all over the world since it spreads easily. Common symptoms are fever, cough, difficulty
in breathing and muscle aches. Despite the urgent need to find an effective antiviral treatment, already
available agents are being used alone or in combination all over the world. At the beginning
of the pandemic, death rates of infection caused by COVID-19 are high but “is COVID-19 responsible
for all deaths?”, or “are there any contributions of the frequently used drugs in this period to these
deaths?” Surely herd immunity plays a major role and has contributed to the decline in mortality
rates. Meanwhile, it is kept in mind that due to safety concerns, changes have also been made in
the dosage and combined use of frequently used drugs.

Objective:
In this review, answers to two questions above and the safety of treatments, toxicities of
agents involving chloroquine, hydroxychloroquine, remdesivir, favipiravir, lopiravir/ritonavir, sarilumab,
tocilizumab, siltuximab, corticosteroids and bromhexine which are the most frequently
used in Turkey and all over the world will be summarized.

Conclusion:
Among these drugs, favipiravir seems the most promising drug due to more tolerable
adverse effects. More clinical trials with large sample sizes are needed to find the most effective
and safe drug for COVID-19 treatment.
Molecular Fingerprinting by Single Cell Clone Analysis in Adverse Drug
Reaction (ADR) Assessment
Authors: Banerjee Anjan K. 
Published: July 2021

:
Causality assessment for idiosyncratic ADRs mainly relies on epidemiology, signal detection
and less often on proven or plausible mechanistic evidence of the drug at a cellular or organ
level. Distinct clones of cells can exist within organs of individual patients, some conferring susceptibility
to well-recognised Adverse Drug Reactions (ADRs). Recent advances in molecular biology
have allowed the development of single-cell clonal techniques, including single-cell RNA sequencing
(scRNA-seq) to molecularly fingerprint ADRs and distinguish between distinct clones of
cells within organs in individuals, which may confer differing susceptibilities to ADRs. ScRNA-
seq permits molecular fingerprinting of some serious ADRs, mainly in the skin, through the
identification of Directly Expressed Genes (DEG) of interest within specific clones. Overexpressed
DEGs provide an opportunity for targeted treatment strategies to be developed. scRN A-seq could
be applied to a number of other ADRs involving tissues that can be biopsied/sampled (including
skin, liver, kidney, blood, stem cells) as well as providing a molecular basis for rapid screening of
potential therapeutic candidates, which may not otherwise be predictable from a class of toxicity/organ
involvement. A framework for putative assessment for ADRs using scRNA-seq is proposed as
well as speculating on potential regulatory implications for pharmacovigilance and drug development.
Molecular fingerprinting of ADRs using scRNA-seq may allow better targeting for enhanced
pharmacovigilance and risk minimisation measures for medicines with appropriate benefit-risk profiles,
although cost-effectiveness and other factors, such as frequency/severity of individual ADRs
and population differences, will still be relevant.
Variability of Pharmacogenomics Information in Drug Labels Approved
by Different Agencies and its Ethical Implications
Authors: Güner Müberra Devrim , Ekmekci Perihan Elif , Kurtoglu Berra 
Published: July 2021

Aims:
The aim of this study was to determine if there are discrepancies among various
agency-approved labels for the same active ingredient and where the labels approved by the Turkish
Medicines and Medical Devices Agency (TMMDA) stand regarding the inclusion of PGx and
discuss these ethical implications.

Background:
The efficacy and safety of drugs can be improved by rational prescription and personalization
of medicine for each patient. Pharmacogenomics information (PGx) in Drug Labels (DL)
is one of the important tools for the personalization of medications because genetic differences
may affect both drug efficacy and safety. Providing adequate PGx to patients has ethical implications.

Objective:
The study aims to evaluate PGx in the DLs approved by TMMDA and other national
agencies provided by the Pharmacogenomics Knowledgebase.

Methods:
DL annotations from the Pharmacogenomics Knowledgebase and DLs approved by the
TMMDA were analyzed according to information and action levels, which are “testing required”,
“testing recommended”, “actionable”, and “informative”.

Results:
There are 381 drugs listed in PharmGKB drug label annotations with pharmacogenomics
information, and 278 of these have biomarkers. A total of 242 (63.5%) drugs are approved and available
in Turkey. Of these, 207 (85.5%) contain the same information as in or similar to that in the
labels approved by the other agencies. The presence and level of information varied among the
DLs approved by different agencies. The inconsistencies may have an important effect on the efficacy
and the safety of drugs.

Conclusion:
These findings suggest a need for the standardization of PGx information globally because
it may not only affect the efficacy and safety of medications but also essential ethical rules regarding
patient rights by violating not sufficiently sharing all available information.
The Effects of Lifestyle Intervention Using the Modified Beliefs, Attitude, Subjective Norms, Enabling Factors Model in Hypertension Management: Quasi-Experimental Study
Authors: Villarino Resti Tito , Arcay Christopher Asuncion , Temblor Maria Concepcion , Villarino Maureen Lorence , Bagsit Rosita , Ocampo Lanndon , Bernard Paquito 
Published: July 2021

Background
Hypertension is a serious health issue and a significant risk factor for cardiovascular disease and stroke. Although various health education models have been used to improve lifestyle in patients with hypertension, the findings have been inconsistent.

Objective
This study aims to assess the effects of a lifestyle intervention program using a modified Beliefs, Attitude, Subjective Norms, Enabling Factors (BASNEF) model among nonadherent participants with hypertension in managing elevated blood pressure (BP) levels.

Methods
This study reports a quantitative quasi-experimental research work, particularly using a repeated-measures design of the within-subjects approach on the 50 nonadherent patients who received a diagnosis of essential hypertension in Cebu, Philippines. The research participants received 5 sessions of training based on a modified BASNEF model. An adherence instrument was used as an evaluation platform. The first phase gathers participants' relevant profiles and background, and the final phase gathers participants' systolic BP, diastolic BP, heart rate, and adherence scores.

Results
The results indicate that the phase 1 mean systolic readings (146.50, SD 19.59) differ significantly from the phase 4 mean systolic readings (134.92, SD 15.24). They also suggest that the lifestyle intervention based on session III or phase IV behavioral intention in the BASNEF model microgroup sessions positively affects BP readings among the research participants.

Conclusions
This study has established that the BASNEF model approach can be a good BP management technique.
Hydrothermal Treatment of Herb Residue for Solid Fuel Production
Authors: Surahmanto Fredy , Nurhadiyanto Didik , Mujiyono Mujiyono , Areeprasert Chinnathan , Syamsiro Mochamad 
Published: July 2021

Hydrothermal processing is appraised as one of advanced technologies for wet solid waste handling. In this study, herb residue was subjected to hydrothermal treatment. Calorific value, yield, and also proximate analysis of obtained hydro-char were investigated. A cylindrical reactor with an internal volume of 2.5 Litres made of stainless steel and a low-tech component was used in the experiment. The reactor was equipped with a stirrer to ensure heat transfer took place through the entire parts of the solid-water mixture. Solid products were dried by a microwave oven before analysis. The results show that the final temperature, holding time, and solid-water ratio have various effects on the hydro-char yield, calorific value, and proximate analysis of the hydrothermal products. The hydro-char yield decreased with the increase in final temperature and holding time. Meanwhile, the highest hydro-char yield was obtained at the solid-water ratio of ¼. The hydro-char calorific value increased with the increase in final temperature, holding time, and solid-water ratio. The rise in final temperature, holding time, and solid-water ratio resulted in a lower moisture content and volatile matter but higher fixed carbon. Meanwhile, the ash content increased with the solid-to-water ratio.
Prefacio
Authors: Israde-Alcántara Isabel , Macías-Vázquez José Luis 
Published: July 2021

En octubre del 2019 la comunidad nacional e internacional de Ciencias de la Tierra fue partícipe del sensible fallecimiento del Dr. Víctor Hugo Garduño Monroy. Víctor Hugo fue conocido no solo por sus contribuciones al conocimiento de la Tectónica de México con fines del entendimiento de la prospección geológica del Petróleo y de la Geotermia en México, sino también por impulsar en nuestro país estudios pioneros de paleosismología. De igual forma trabajó en la interpretación geológico-ambiental de los glifos prehispánicos, lo cual fue su pasión en sus últimos años. Rebasó hipótesis, creando verdades que mediante su visión se hicieron evidentes, marcando así un parteaguas en la investigación de frontera en las distintas aplicaciones de la Geología Estructural. Durante su brillante carrera académica Víctor Hugo cambió la vida de numerosos investigadores y alumnos que fuimos impulsados por su esencia, su simpatía y contagiosa positividad. Su principal laboratorio natural fue su natal Michoacán, donde la comunidad científica admiró su talento para “comunicarse con la Tierra”. En esa su tierra, dedicó muchos años al estudio de los volcanes y apuntaló su célebre frase “La Tierra y los volcanes son de quienes los trabajan”. Por su talento y grandes contribuciones, Víctor Hugo, como lo conocíamos, no será fácilmente olvidado.
En esta sección especial reunimos contribuciones dedicadas a la geología de Michoacán, las cuales rinden homenaje a la vida y obra de nuestro querido Maestro y amigo Víctor Hugo. Los tópicos que cubren estas contribuciones son la geología estructural, vulcanología, el paleomagnetismo, la paleosismologia, riesgos geológicos y planificación territorial. Todos estos trabajos forman parte de una revisión el estado del arte de investigaciones en distintas áreas del conocimiento en Michoacán. En muchas de estas contribuciones Víctor Hugo es coautor, porque estaba trabajando intensamente con sus colaboradores antes de su partida. El primer artículo se refiere a la formación de conos de escoria asociados a una cámara magmática somera y su relación con la topografía y clima dentro del Campo Volcánico de Michoacán-Guanajuato.
Otros artículos serán publicados en los siguientes números de la Revista Mexicana de Ciencias Geológicas.
Factores de riesgo psicosocial y su asociación con el ausentismo laboral
Authors: Espino-Porras C.L. , De Luna-López M.C. , Flores-Padilla L. , Ramírez-Echavarría E.J. , Brito-Cerino M.I. , Gómez-Jurado L.J. 
Published: July 2021

Introducción: El ausentismo no programado se relaciona a condiciones laborales deficientes, riesgos psicosociales ocupacionales, falta de satisfacción laboral y otros factores biológicos, físicos y psicológicos. La reducción de costos en las instituciones y la disminución del personal contribuyen a generar condiciones laborales desfavorables.
Objetivo: Identificar factores de riesgo psicosociales que influyen en el ausentismo laboral no programado del personal de enfermería, en un centro de segundo nivel de atención en Chihuahua, México.
Métodos: Estudio descriptivo, muestra de 221 enfermeras. Se aplicó Instrumento para Identificar Factores de Riesgo Psicosocial y Evaluar el Entorno Organizacional en los Centros de Trabajo, así como una sección de características sociodemográficas y laborales. Se evalúo asociación estadística con análisis multivariado.
Resultados: El ausentismo representó 61.1%. Se identificó una asociación estadística entre el ausentismo y el ambiente de trabajo con nivel de riesgo muy alto y alto (X2 de 4.03 y 4.72), confirmada con el modelo de regresión logística en el nivel de riesgo Muy Alto coeficiente β = 5.32.
Discusión: La categoría Ambiente de trabajo fue la más relevante en este contexto, resultado similar a otros estudios que han mostrado la influencia de las condiciones de trabajo y del clima organizacional en el ausentismo del personal de enfermería.
Conclusión: Las condiciones de trabajo estresantes consideradas en la Categoría de Ambiente de trabajo tienen consecuencias en el bienestar de los trabajadores, sería necesario realizar otras investigaciones en profesionales de salud, de acuerdo al instrumento de la STPS utilizado, para implementar estrategias de prevención en la salud mental del trabajador.
Un currículum controversial-problematizador: un desafío para la educación de América Latina
Authors: Magendzo K. Abraham 
Published: July 2021

El artículo se propone apostar por un curriculum que alejándose de los modelos tradicionales incursiona en una apuesta que apunta a un modelo problemático–controversial. De esta forma, la propuesta es que el curriculum se aproxime a los temas emergentes y apremiantes que afectan a nuestra sociedad. En síntesis, el artículo profundiza en una postura crítica del curriculum para incorporar una mirada dilemática.
Plant Extract Loaded Nanoparticles
Authors: Husni Patihul , Ramadhania Zelika Mega 
Published: July 2021

Plant extract, a natural source containing complex mixture of compounds, offers many properties such as antiparasitic, antibiotic, antioxidant, anti-hypertensive, antiviral, insecticide, anticancer, antifungal, hypoglycemic properties. Recent research has been focused on developing formulation the plant extracts not only to deliver them safely but also to enhance its therapeutic efficacy. Nanotechnology-based strategies have been proposed as a system that can be used to formulate plant extracts. Plant extract loaded nanoparticles (NPs) is aimed to facilitate in crossing the biological barriers, to increase bioavailability of poorly water-soluble phytochemicals, to encapsulate mixture compounds of different phytochemicals, to provide targeted delivery of phytochemicals to specific organs resulting in low toxicity, to get effective purification process, to mask unpleasant taste and odor, to protect sensitive phytochemicals from biological (e.g. enzyme, pH) and environmental (e.g. light, temperature, humidity) degradation, to control release of encapsulated phytochemicals, and to provide a more flexible control over the size and shape of the NPs. This review is focused on plant extract loaded NPs including its advantages, stages for developing formulation of plant extract loaded NPs, and nanosystem used to loading plant extract. In addition, this review also depicts studies which have been conducted by many researchers in developing plant extract loaded NPs. The data were collected from published journals with 21 and 39 journals as primary and supporting literatures, respectively. Plant extracts loaded NPs could be a promising delivery system for active phytochemical contained in the plant extract which is not only to deliver them safely but also to enhance its therapeutic efficacy.Keywords: plant, extract, nanoparticle