bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Survey on String Constraint Solving
Authors: Amadini Roberto 
Published: November 2021

String constraint solving refers to solving combinatorial problems involving constraints over string variables. String solving approaches have become popular over the past few years given the massive use of strings in different application domains like formal analysis, automated testing, database query processing, and cybersecurity.This article reports a comprehensive survey on string constraint solving by exploring the large number of approaches that have been proposed over the past few decades to solve string constraints.
Metabolite Profiles of the Green Beans of Indonesian Arabica Coffee Varieties
Authors: Happyana Nizar , Pratiwi Amelinda , Hakim Euis Holisotan 
Published: November 2021

The green beans of 3 Indonesian arabica coffee varieties, namely, ateng, buhun, and sigararutang, were analyzed with 1H NMR-based metabolomics coupled with alpha-glucosidase inhibitory activity assay. These coffees were cultivated in the same geographical conditions. The PLSDA model successfully classified the green coffee beans based on their varieties. To reveal the characteristic metabolites for each coffee variety, S-plot of two-class OPLSDA models was generated and analyzed. Ateng coffee was characterized with trigonelline, sucrose, 5-CQA, and acetic acid. The characteristic metabolites of buhun coffee were citric acid and malic acid. Meanwhile, the most discriminant compound of sigararutang coffee was quinic acid. HCA analysis revealed the lineage relationship of the 3 coffee varieties. Ateng coffee had closer lineage relationship to sigararutang compared to the buhun coffee. Alpha-glucosidase inhibitory activity of the coffee samples did not differ widely.

I

C

50

values of alpha-glucosidase inhibitory activity of ateng, sigararutang, and buhun coffees were

3.01
±
0.16

,

3.14
±
0.20

, and

5.05
±
0.28

mg/mL, respectively. Although grown in the same geographical conditions, our results revealed that each coffee variety possessed a unique metabolome clarifying the diversity of Indonesian arabica coffees. This study verified that 1H NMR-based metabolomics is an excellence method for discovering the lineage relationship in the samples with different varieties or cultivars.
Exploitation of Sulfated Glycosaminoglycan Status for Precision Medicine of Triplatin in Triple-Negative Breast Cancer
Authors: Hampton James D. , Peterson Erica J. , Katner Samantha J. , Turner Tia H. , Alzubi Mohammad A. , Harrell J. Chuck , Dozmorov Mikhail G. , Turner Joseph B. McGee , Gigliotti Pam J. , Kraskauskiene Vita , Shende Mayuri , Idowu Michael O. , Puchalapalli Madhavi , Hu Bin , Litovchick Larisa , Katsuta Eriko , Takabe Kazuaki , Farrell Nicholas P. , Koblinski Jennifer E. 
Published: November 2021

Abstract
Triple-negative breast cancer (TNBC) is a subtype of breast cancer lacking targetable biomarkers. TNBC is known to be most aggressive and when metastatic is often drug-resistant and uncurable. Biomarkers predicting response to therapy improve treatment decisions and allow personalized approaches for patients with TNBC. This study explores sulfated glycosaminoglycan (sGAG) levels as a predictor of TNBC response to platinum therapy. sGAG levels were quantified in three distinct TNBC tumor models, including cell line–derived, patient-derived xenograft (PDX) tumors, and isogenic models deficient in sGAG biosynthesis. The in vivo antitumor efficacy of Triplatin, a sGAG-directed platinum agent, was compared in these models with the clinical platinum agent, carboplatin. We determined that &gt;40% of TNBC PDX tissue microarray samples have high levels of sGAGs. The in vivo accumulation of Triplatin in tumors as well as antitumor efficacy of Triplatin positively correlated with sGAG levels on tumor cells, whereas carboplatin followed the opposite trend. In carboplatin-resistant tumor models expressing high levels of sGAGs, Triplatin decreased primary tumor growth, reduced lung metastases, and inhibited metastatic growth in lungs, liver, and ovaries. sGAG levels served as a predictor of Triplatin sensitivity in TNBC. Triplatin may be particularly beneficial in treating patients with chemotherapy-resistant tumors who have evidence of residual disease after standard neoadjuvant chemotherapy. More effective neoadjuvant and adjuvant treatment will likely improve clinical outcome of TNBC.
Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction
Authors: Malhotra Rajeev , Nicholson Christopher J. , Wang Dongyu , Bhambhani Vijeta , Paniagua Samantha , Slocum Charles , Sigurslid Haakon H. , Lino Cardenas Christian L. , Li Rebecca , Boerboom Sophie L. , Chen Yin-Ching , Hwang Shih-Jen , Yao Chen , Ichinose Fumito , Bloch Donald B. , Lindsay Mark E. , Lewis Gregory D. , Aragam Jayashri R. , Hoffmann Udo , Mitchell Gary F. , Hamburg Naomi M. , Vasan Ramachandran S. , Benjamin Emelia J. , Larson Martin G. , Zapol Warren M. , Cheng Susan , Roh Jason D. , O’Donnell Christopher J. , Nguyen Christopher , Levy Daniel , Ho Jennifer E. 
Published: November 2021

Objective:
Arterial stiffness is a risk factor for cardiovascular disease, including heart failure with preserved ejection fraction (HFpEF). MGP (matrix Gla protein) is implicated in vascular calcification in animal models, and circulating levels of the uncarboxylated, inactive form of MGP (ucMGP) are associated with cardiovascular disease-related and all-cause mortality in human studies. However, the role of MGP in arterial stiffness is uncertain.

Approach and Results:

We examined the association of ucMGP levels with vascular calcification, arterial stiffness including carotid-femoral pulse wave velocity (PWV), and incident heart failure in community-dwelling adults from the Framingham Heart Study. To further investigate the link between MGP and arterial stiffness, we compared aortic PWV in age- and sex-matched young (4-month-old) and aged (10-month-old) wild-type and Mgp
+/−
mice. Among 7066 adults, we observed significant associations between higher levels of ucMGP and measures of arterial stiffness, including higher PWV and pulse pressure. Longitudinal analyses demonstrated an association between higher ucMGP levels and future increases in systolic blood pressure and incident HFpEF. Aortic PWV was increased in older, but not young, female Mgp
+/−
mice compared with wild-type mice, and this augmentation in PWV was associated with increased aortic elastin fiber fragmentation and collagen accumulation.

Conclusions:
This translational study demonstrates an association between ucMGP levels and arterial stiffness and future HFpEF in a large observational study, findings that are substantiated by experimental studies showing that mice with Mgp heterozygosity develop arterial stiffness. Taken together, these complementary study designs suggest a potential role of therapeutically targeting MGP in HFpEF.
From Academic Anthropology to Esoteric Religion
Authors: Kostićová Zuzana Marie 
Published: November 2021

Abstract
Carlos Castaneda has been studied mostly as a fraud anthropologist, novelist/philosopher and a contributor to the emerging phenomenon of neo-shamanism. Instead, this article focuses on Castaneda’s individual philosophy and religious system as developed in his written works. A threefold classification is proposed—early, transitional, and late works, complete with chief characteristics of each. The analysis shows how Castaneda slowly drifted from the scholarly style through stress on the narrative to full-fledged religious texts. These changes also reflect on Castaneda’s personal life; from academic ambition through public scandal ‘debunking’ his counterfeit works to the formation of a little new religious movement, of which Castaneda was a charismatic leader. Unlike most scholarly analyses of Castaneda that focus mainly on the early writings, this article takes into serious consideration his late works and shows that it was here that the author fully developed as a religious thinker and guru.
Jihad as an Individual Duty (farḍ al-ʻayn) in the Ideology of Circassian Sultans (1382–1517)
Authors: Zelenev Evgeny I. , Iliushina Milana 
Published: November 2021

This article is devoted to the study of the development of the theory and practice of jihad during the rule of the Circassian sultans in Egypt and Syria (1382–1517). The purpose of the study is to trace the development of key aspects of jihad, to identify features of its perception in the Mamluk state. An essential feature of the theory of jihad in the Mamluk period is the interpretation of jihad as farḍ al-ʿayn (the individual duty of every Muslim).
While studying the theory of jihad, the authors rely on a holistic and balanced approach justified in the papers of M. Bonner and D. Cook and their interpretation of the concept of jihad, which has a centuries-old history of development and a sophisticated, multi-layered set of meanings. Another methodological basis of the present paper was the concept of minimalism and maximalism, developed by Yusef Waghid.
The source base for the study of jihad theory is the works of Ibn al-Nahhas (d. 1411), a prominent philosopher of the Mamluk era. The interpretation of jihad as an individual duty of every Muslim, substantiated by Ibn al-Nahhas, was the foundation of the volunteer movement that developed in Egypt and Syria in the 15th century.
The doctrine of jihad where the concepts of justice (al-‘adl) and truth (al-ḥaqq) play a key role, was used by the Mamluks and then by the Ottomans as a powerful ideological tool to manipulate the minds of Muslims. The relevance of the study is that the findings are not only true for the Middle Ages but are directly related to the present.
Colloquium 1 Dialectic, Persuasion, and Science in Aristotle
Authors: Dow Jamie 
Published: November 2021

Abstract
What is dialectic and what is it for, in Aristotle? Aristotle’s answer in Topics 1.2 seems surprisingly lacking in unity. He seems to imply that insofar as dialectic is an expertise (τέχνη), it is a disposition to three (possibly four) different kinds of productive achievement. Insofar as dialectic is a method, it is one whose use is seemingly subject to multiple, differing standards of evaluation. The goal of the paper is to resist this problematic “multi-tool” view of Aristotelian dialectic, by explaining how dialectic’s contributions to training, encounters, and the philosophical sciences are of the same kind. What unifies them, I argue, is the kind of reasoning that improves the epistemic position of the person that engages with it. The kind of reasoning-based practices in which dialectic is the expertise are, at heart, tools of inquiry, tools for improving people’s understanding. This is why dialectic is beneficial for persuasive encounters: it is an expertise that enables its possessor to persuade by improving the understanding of their participants.
Colloquium 2 Commentary on Trott
Authors: Lockwood Thornton C. 
Published: November 2021

Abstract
In her “Saving the Appearances of Plato’s Cave,” Dr. Adriel M. Trott argues that “the philosopher’s claim to true knowledge always operates within the realm of the cave.” In order to probe her claim, I challenge her to make sense of “politics in the cave,” namely, the status and practices of two categories of people in the cave: “woke” cave-dwellers (namely, those who recognize shadows as shadows but have not left the cave) and “woke” puppeteers (namely, philosophers ruling within the cave).
Colloquium 3 Commentary on Elliott
Authors: Sim May 
Published: November 2021

Abstract
Jay Elliott considers Aristotle’s view on the voluntariness of virtue and vice in his Nicomachean Ethics III.5 by exploring two rival interpretations. According to Elliott, the libertarian reading emphasizes the freedom that mature agents have to change their characters after rational reflection but neglects the role that upbringing plays in character formation. In contrast, the compatibilist reading stresses the agents’ upbringing in shaping their beliefs and desires. Elliott explains that because compatibilists maintain that agents’ actions stem from their own beliefs and desires, their actions, which reveal their character, are voluntary. Nevertheless, Elliott holds that because the agents, for the compatibilists, lack the power to change their beliefs and desires, the compatibilist account downplays the voluntariness of character in Aristotle’s own view. Elliott criticizes these rival interpretations and focuses on the concept of “practice” to argue that Aristotle’s view of character is both voluntary and subject to one’s upbringing. I discuss Aristotle’s concepts of voluntariness and practice in evaluating Elliott’s interpretation.
Colloquium 5 Anger and Our Humanity: Transhumanists Stoke the Flames of an Ancient Conflict
Authors: Levin Susan B. 
Published: November 2021

Abstract
This paper presents Stoicism as, in broad historical terms, the point of origin in Western thought of an extreme form of rational essentialism that persists today in the debate over human bioenhancement. Advocates of “radical” enhancement (or transhumanists) would have us codify extreme rational essentialism through manipulation of genes and the brain to maximize rational ability and eliminate the capacity for emotions deemed unsalutary. They, like Stoics, see anger as especially dangerous. The ancient dispute between Stoics and Aristotle over the nature and permissibility of anger has contemporary analogues. I argue that, on the merits, this controversy should, finally, be put to rest in Aristotle’s favor. Beyond its philosophical assets, Aristotle’s perspective meshes well with “appraisal theory” of emotion in psychology and corresponding discoveries in neuroscience. What’s more, consideration of the ongoing struggle to achieve full racial equality in the United States supports the view that anger at this ongoing gap between λόγος and ἔργον is legitimate, and has a constructive role to play in furthering liberal democracy. As we are well positioned to retire the Stoics’ legacy regarding anger, all the more should we eschew transhumanists’ proposal to implement their position biologically, at which point debate over the nature and worth of anger would be permanently moot.
A 90-day Sub-chronic Oral Toxicity Assessment of Mulberry Extract in Sprague Dawley Rats
Authors: Hong Min , Lu Min , Qian Yimin , Wei Liping , Zhang Yaqun , Pan Xueying , Li Hua , Chen Huaying , Tang Naping 
Published: November 2021

Mulberry extract from Fructus Mori contains an anthocyanin pigment and has been widely used as a food additive in China and other Eastern Asian countries. Only few research has been done on toxicological profiling of mulberry extract for its safety evaluation; however, the data is inconclusive. In the current study, mulberry extract of 4200, 1400, or 466 mg/kg were orally administrated to Sprague Dawley rats for 90 consecutive days followed by a recovery period of 28 days. No abnormalities were detected in body weights, food intake, ophthalmological, hematological, coagulation, clinical chemistry, and organ weights parameters. Discoloration of urine (red, purple, and brown) and feces (black), along with bedding material (purple) were observed in the 4200 mg/kg group. Further, microscopic examination revealed brown granules in the renal tubular cells for rats in 4200 and 1400 mg/kg groups. Since these changes were associated with excretory effect of the extract, the No Observed Adverse Effect Level was determined to be 4200 mg/kg, which was equivalent to the 1058.5 mg/kg of anthocyanin.
Using a Social Determinants of Health Summary Measure to Predict General Health Status in the BRFSS
Authors: Nelson Candace C. 
Published: November 2021

PurposeThis study aims to assess the relationship between social determinants of health (SDoH) burden and overall health.DesignThree years of Behavioral Risk Factor Surveillance System (BRFSS) data (2017–2019) were combined for this cross-sectional study.SettingMassachusetts.SubjectsOut of a possible 21,312 respondents, 16,929 (79%) were eligible for inclusion.MeasuresTo create the SDoH summary measure, items assessing social risk experiences including financial instability (1 item), housing instability (2 items), perceptions of neighborhood crime (1 item), and food insecurity (2 items) were summed to create a count of risk experiences. Outcome measures included self-rated general health, days of poor physical health, and days of poor mental health.AnalysisMultivariable logistic regression was used to evaluate the association between each outcome and the SDoH summary measure, adjusting for demographic confounders.ResultsIn adjusted analyses, respondents who reported experiencing 1, 2, 3, or 4+ SDoH had a 1.6 (95% CI: 1.3–2.0), 2.9 (95% CI: 2.3–3.7), 3.2 (95% CI: 2.4–4.3), or 5.3 (95% CI: 4.0–7.0) increased odds (respectively) of self-rated fair/poor health, compared to those who reported zero SDoH. The adjusted relationship between the SDoH summary measure and physical health and mental health was similar in magnitude and statistically significant.ConclusionsThese results demonstrate that the overall burden of risk due to SDoH is an important predictor of health.
Sensitivity and specificity of Sirius indices in diagnosis of keratoconus and suspect keratoconus
Authors: Salman Abdelrahman , Darwish Taym , Ali Ali , Ghabra Marwan , Rafea Shaaban  
Published: November 2021

Aim To estimate the sensitivity and specificity of topographic and tomographic corneal parameters as determined by Sirius (CSO, Florence, Italy) in discriminating keratoconus (KC) and suspect keratoconus from normal cornea. Method In this retrospective case-series study, keratoconus screening indices were measured using Sirius tomographer. Receiver operating characteristics (ROC) curves were used to determine the test's overall predictive accuracy (area under the curve) and to identify optimal cut-off points to maximize sensitivity and specificity in differentiating keratoconus and suspect keratoconus from normal corneas. Results Receiver operating characteristics (ROC) curve analyses showed high predictive accuracy for Symmetry Index back (SIb), Keratoconus Vertex front (KVf), Symmetry Index front (SIf), Keratoconus Vertex back (KVb), Apex Keratometry (Curve-Apex) and Minimum corneal Thickness (ThkMin) to distinguish keratoconus from normal (area under the curve > 0.9, all). Symmetry Index back was identified as the best diagnostic parameter for detecting suspect keratoconus with AUC of 0.86. Highest specificity to detect keratoconus and suspect keratoconus was seen for SIb, 99.87% and 84.66%, respectively. These values were associated with optimal cut-off points of 0.46 D for keratoconus and 0.12 D for suspect keratoconus. Conclusion Sirius parameters evaluated in the study were effective to differentiate keratoconus from normal corneas. However, Symmetry Index back was the index with the highest ability to detect suspect keratoconus.
Perinatal outcomes of intrahepatic cholestasis of pregnancy from two birth cohorts: A population-based study
Authors: Al-Obaidly Sawsan , Salama Husam , Olukade Tawa , AlQubaisi Mai , Bayo Arabo , Al Rifai Hilal 
Published: November 2021

Background Intrahepatic cholestasis of pregnancy (ICP) is a complex liver disease with varying incidence worldwide. We compared ICP incidence and pregnancy outcomes with outcomes for normal pregnant controls. Methods We conducted a retrospective data analysis of perinatal registry data for the years 2011 and 2017 to compare the following outcome measures: stillbirths, labour induction, gestational diabetes, pre-eclampsia, antepartum haemorrhage, postpartum haemorrhage, preterm births, low Apgar score, acute neonatal respiratory morbidity, meconium aspiration and in-hospital neonatal death. Results The incidence of ICP was 8 per 1000 births from a total 31,493 singleton births with more cases in 2017 than in 2011. Women with ICP were almost six times more likely to have labour induced including significantly more moderate preterm births (defined as between 32 weeks and 36 weeks and 6 days of gestation)) seen more in 2011 than in 2017. Conclusion Women with ICP showed higher incidence of moderate preterm birth and induced labour but favourable maternal and neonatal outcomes.
Development of a Personalized Near-Peer Mentoring Programme for Final-Year Medical Students with Residents as Mentors
Authors: Yap Angela Frances, Hui Wen , Ruan Xucong , Fong Warren Weng Seng 
Published: November 2021

Background Near-peer mentoring is a process where a mentor is close to the social, professional, or age level of the mentee. Near-peer mentors are better able to interact with and understand the struggles of students. Objective The aim of the programme was to increase confidence of students in the final year examination. Methods Following a needs analysis of final-year medical students, a near-peer mentoring programme was designed using peer-assisted learning framework. In the programme conducted between November 2019 and March 2020, trained Internal Medicine junior residents were assigned to students grouped according to the examination domains they most needed improvement in. Pre- and post-intervention data on students’ confidence in each of the examination domains using a 5-point Likert scale (1: Not confident at all and 5: Very confident), mock examination scores and feedback on the programme were collected. Results Fifty-one students were enrolled. Thirty-one students completed the post-programme survey, of which 71.0% felt more confident in the final year examination. Of the twenty-eight students who completed both the pre- and post-programme survey, 78.6%, 78.6% and 60.7% of them showed an increase in confidence in the communications, physical examination and history component of the examination, respectively. There was no association found between confidence level and examination performance. Conclusion A personalized near-peer mentoring programme is effective in increasing confidence of students in examinations and serves as a platform for residents to hone their skills as mentors. Its role as part of the medical school curriculum is worth exploring.
Use of Receptor Occupancy Assays on Cells from Peripheral Blood As a Model to Determine Therapeutic Efficacy
Authors: Jones Nicholas , Davis Floyd , Fancke Benjamin , Ngo Brian , Limson Jessica 
Published: November 2021

Abstract
In the development of monoclonal antibodies for the treatment of liquid or solid tumors, monitoring receptor occupancy (RO) on peripheral blood lymphocytes can help illustrate potential therapeutic activity occurring systemically, or in the tumor environment. There is increased interest in using these assessments on cells from the periphery to assess the efficacy of investigational therapies. In this area of therapeutic development, much focus has been placed on checkpoint inhibition proteins/receptors such as PD-1, PD-L1, TIM3, CTLA-4, TIGIT, and multiple others. These immune checkpoint inhibitors are suitable targets since they can be highly modulated on exhausted T cells in cancer patients. In the case of solid tumors, assessing the expression of these markers in the tumor itself via biopsy would be an invasive process that could not be performed sequentially and, therefore, would provide little information to correlate with pharmacokinetic results throughout the course of a clinical trial to determine timing and optimal dose selection. However, assessment of the receptor expression and occupancy in combination with pharmacokinetics can lead to a better understanding of drug levels required to achieve optimal therapeutic performance. Monitoring the expression and binding of these molecules by a drug can determine specific treatment based on the ability of the patient's own immune system to act, while providing information to identify therapeutic responses against cancer. This poster will present an example of receptor occupancy (RO) assessment in its development and implementation.

Disclosures
No relevant conflicts of interest to declare.