bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frontal Sinus Fractures
Authors: Podolsky Dale J. , Moe Kris S. 
Published: October 2021

AbstractManagement of frontal sinus fractures is controversial with no universally accepted treatment protocol. Goals of management are to correct aesthetic deformity, preserve sinus function when it is deemed salvageable, prevent sequela related to the injury, and minimize complications associated with intervention. Studies suggest that frontal sinus injuries, including disruption of the nasofrontal outflow tract (NFOT), can be managed nonoperatively in many cases. Advances in the utilization of endoscopic techniques have led to an evolution in management that reduces the need for open procedures, which have increased morbidity compared with endoscopic approaches. We employ a minimally disruptive protocol that treats the majority of fractures nonoperatively with serial clinical and radiographic examinations to assess for sinus aeration. Surgical intervention is reserved for the most severely displaced and comminuted posterior table fractures and unsalvageable NFOTs utilizing endoscopic approaches whenever possible.
First application of a digital mirror Langmuir probe for real-time plasma diagnosis
Authors: McCarthy W. , Golfinopoulos T. , Woller K. B. , Vincent C. , Kuang A. , Labombard B. 
Published: October 2021

For the first time, a digital Mirror Langmuir Probe (MLP) has successfully sampled plasma temperature, ion saturation current, and floating potential together on a single probe tip in real time in a radio-frequency driven helicon linear plasma device. This is accomplished by feedback control of the bias sweep to ensure a good fit to I–V characteristics with a high frequency, high power digital amplifier, and field-programmable gate array controller. Measurements taken by the MLP were validated by a low speed I–V characteristic manually collected during static plasma conditions. Plasma fluctuations, induced by varying the axial magnetic field (f̃ = 10 Hz), were also successfully monitored with the MLP. Further refinement of the digital MLP pushes it toward a turn-key system that minimizes the time to deployment and lessens the learning curve, positioning the digital MLP as a capable diagnostic for the study of low radio-frequency plasma physics. These demonstrations bolster confidence in fielding such digital MLP diagnostics in magnetic confinement experiments with high spatial and adequate temporal resolution, such as edge plasma, scrape-off layer, and divertor probes.
L2 emails of complaints
Authors: Nguyen Thi Thuy Minh , Pham Thi Thanh Thuy 
Published: October 2021

Abstract
In this chapter, we analysed the emails of complaints written by 48 low- and high-proficiency Vietnamese EFL learners when communicating with different audiences. The emails were elicited by means of a computerised discourse completion task developed by an international testing organisation. To understand the cognitive processes involved in the learners’ production of complaints, we also analysed think-aloud protocols provided by 8 learners randomly selected from the above pool. Our findings indicate some effect of proficiency on the learners’ pragmatic performance and decision-making processes. However, our findings also show that regardless of proficiency levels, the learners tended to neglect important writing processes. The findings suggest that the learners require pragmatic instruction as well as training in writing processes in order to carry out the email-writing task more effectively.
Long-term instructional effects on learners’ use of email request modifiers
Authors: Usó-Juan Esther 
Published: October 2021

Abstract
This study followed a pre-test/post-test/delayed post-test design to investigate the long-term impact of metapragmatic instruction on learners’ ability to modify email requests. Twenty-five Spanish university students with an upper-intermediate proficiency level in English participated in the study. Over a two-week period, they received six hours of instruction on request modifiers by applying a form-function-context mapping framework (Taguchi 2011). Target request modifiers in written Discourse Completion Tasks (DCTs) were analysed for frequency and variety. Learners’ self-evaluations of email appropriateness were also used to determine their degree of confidence when producing request modifiers. The within-group comparisons revealed that learners made a significant progress in their use of request modifiers and confidence level immediately after instruction and two months later. These comparisons, however, also indicated that some types of request modifiers were more amenable to instruction than others.
Experts and novices
Authors: Halenko Nicola , Winder Lisa 
Published: October 2021

Abstract
This longitudinal study seeks to contribute to a shortage of email investigations examining expert (L1) and novice (L2) English practices and tracking L2 developmental change during a UK study abroad period. Using a corpus of 315 authentic request emails, distinct features of Chinese ESL and British students’ email practices were examined, in addition to changes in Chinese ESL practices between the beginning and end of the ten-month period abroad. Findings firstly indicated that choice of request strategies, internal modification, and request perspective showed much variation between the two groups due to different approaches to projecting politeness. Secondly, exposure to the L2 and engagement in email writing had minimal impact on pragmatic performance over the academic year.
Phatic communion in Chinese students’ gratitude emails in English
Authors: Ren Wei , Liu Wenjie 
Published: October 2021

Abstract
This study investigates Chinese students’ production and perception of phatic communion in English gratitude emails to professors. The data were collected in two parts. First, a total of 78 Chinese graduate students were asked to write a thank-you email in English to a professor in a hypothetical academic situation. Their phatic communion strategies were coded and statistically analysed. Second, a separate group of 53 Chinese students were asked about their perceptions of the phatic expressions via questionnaires. The findings are discussed with respect to the preference for phatic communion in Chinese culture, the legitimacy of L1 pragmatics in L2 email communication, and the difficulties of L2 sociopragmatic development in foreign language contexts.
Edge Raman enhancement at layered PbI2 platelets induced by laser waveguide effect
Authors: Ma Heyi , Wu Xianxin , Du Wenna , Zhao Liyun , Zhong Yangguang , Chen Shulin , Gao Peng , Yue Shuai , Zhang Qing , Liu Wei , Liu Xinfeng 
Published: October 2021

Abstract
As a two-dimensional (2D) layered semiconductor, lead iodide (PbI2) has been widely used in optoelectronics owing to its unique crystal structure and distinctive optical and electrical properties. A comprehensive understanding of its optical performance is essential for further application and progress. Here, we synthesized regularly shaped PbI2 platelets using the chemical vapor deposition method. Raman scattering spectroscopy of PbI2 platelets was predominantly enhanced when the laser radiated at the edge according to Raman mapping spectroscopy. Combining the outcome of polarized Raman scattering spectroscopy and finite-difference time domain simulation analysis, the Raman enhancement was proven to be the consequence of the enhancement effects inherent to the high refractive index contrast waveguide, which is naturally formed in well-defined PbI2 platelets. Because of the enlarged excited area determined by the increased propagation length of the laser in the PbI2 platelet formed waveguide, the total Raman enhancements are acquired rather than a localized point enhancement. Finally, the Raman enhancement factor is directly related to the thickness of the PbI2 platelet, which further confirms the waveguide-enhanced edge Raman. Our investigation of the optical properties of PbI2 platelets offers reference for potential 2D layered-related optoelectronic applications.
Agaciro, vernacular memory, and the politics of memory in post-genocide Rwanda
Authors: Mwambari David 
Published: October 2021

Abstract
Recent debates in post-genocide and post-war Rwanda have explored how official commemorations of the Genocide Against the Tutsi in many ways borrow and ‘mimic’ the Holocaust memory ‘paradigm’. The academic canon on post-1994 Rwanda focuses the mostly on politics around this official memory that has evolved into hegemonic memory and on how it has been mobilized to promote a selective memory of the past. However, there is little analysis of vernacular, bottom-up memory practices that have evolved alongside the official one. Using observation, semi-structured interviews, and secondary sources, this article examines vernacular memory practices of mourning the wartime missing in Rwanda. Through the concepts of ‘multidirectional’ and ‘traveling’ memory, this study examines how survivors of these interconnected violent histories that unfolded in two different countries claim multi-faceted Agaciro (dignity, self-respect, and self-worth) through two different memory approaches. The article argues that while actors in official memory approach claim Agaciro through borrowing from another global hegemonic memory, respondents in this study created vernacular avenues to remember their missing loved ones. The article finds that while hegemonic memory might appear to only compete with vernacular memory, there are also ‘knots’ that connect these two memory forms in Rwanda’s context and beyond. In its conclusion, the article proposes an Agaciro-centred approach to examine the relationships between official and unofficial memory practices that have been reenergized through protests both offline and online in Rwanda and beyond. The article contributes to scholarship on Rwanda’s post-genocide memory politics, transcultural memory, and decolonial perspectives on dignity.
Efficient production of isomaltose and isomaltooligosaccharides from starch using 1,4-α-glucan 6-α-glucosyltransferase and isopullulanase
Authors: Kitagawa Noriaki , Watanabe Hikaru , Mori Tetsuya , Nishimoto Tomoyuki , Aga Hajime , Ushio Shimpei , Yamamoto Koryu 
Published: October 2021

ABSTRACT
We attempted to develop an efficient method for producing isomaltose, a disaccharide consisting of an α-(1→6)-linkage, from starch by combining enzymes of known activity. We found that the combination of 1,4-α-glucan 6-α-glucosyltransferase from Bacillus globisporus N75 and isopullulanase from Aspergillus brasiliensis ATCC 9642 led to the efficient synthesis of isomaltose. Inclusion of isoamylase and cyclomaltodextrin glucanotransferase resulted in increased efficiency, with production yields exceeding 70%. Furthermore, we considered that isomaltooligosaccharides could be synthesized from starch by combining 1,4-α-glucan 6-α-glucosyltransferase from Paenibacillus sp. PP710 and isopullulanase. In reactions that additionally utilized isoamylase and α-amylase, the total concentration of product, which included a series of isomaltooligosaccharides from isomaltose to isomaltodecaose, was 131 m m, and the ratio of 6-linked glucopyranosyl bonds to all bonds was 91.7% at a substrate concentration of 10%. The development of these manufacturing methods will accelerate the industrial production of isomaltose and isomaltooligosaccharides.
Mixed polysaccharides derived from shiitake mushroom, Poriacocos, Ginger, and Tangerine peel prevent the H1N1 virus infections in mice
Authors: Yang Diqi , Hu Minghua , Zhu Hongmei , Chen Jianguo , Wang Dehai , Ding Mingxing , Han Li 
Published: October 2021

ABSTRACT
The pandemic influenza A (H1N1) virus spread globally and posed one of the most serious global public health challenges. The traditional Chinese medicine is served as a complementary treatment strategy with vaccine immunization. Here, we demonstrated that the mixed polysaccharides (MPs) derived from shiitake mushroom, poriacocos, ginger, and tyangerine peel prevent the H1N1 virus infections in mice. MP pretreatment attenuated H1N1 virus-induced weight loss, clinical symptoms, and death. The lymphocytes detection results showed that the CD3+, CD19+, and CD25+ cell proportions were upregulated in thymus under MP pretreatment. Besides, MP pretreatment reduced the inflammatory cell infiltration and increased the cell proportions of CD19+, CD25+, and CD278+ in lung. However, MP treatment have no effective therapeutic effect after H1N1 virus challenge. The current study suggested that pretreatment with MPs could attenuate H1N1 virus-induced lung injury and upregulate humoral and cellular immune responses in nonimmunized mice.
Natural tetramic acids elicit multiple inhibitory actions against mitochondrial machineries presiding over oxidative phosphorylation
Authors: Unten Yufu , Murai Masatoshi , Sakai Katsuyuki , Asami Yukihiro , Yamamoto Takenori , Masuya Takahiro , Miyoshi Hideto 
Published: October 2021

ABSTRACT
The mitochondrial machineries presiding over ATP synthesis via oxidative phosphorylation are promising druggable targets. Fusaramin, a 3-acyl tetramic acid isolated from Fusarium concentricum FKI-7550, is an inhibitor of oxidative phosphorylation in Saccharomyces cerevisiae mitochondria, although its target has yet to be identified. Fusaramin significantly interfered with [3H]ADP uptake by yeast mitochondria at the concentration range inhibiting oxidative phosphorylation. A photoreactive fusaramin derivative (pFS-5) specifically labeled voltage-dependent anion channel 1 (VDAC1), which facilitates trafficking of ADP/ATP across the outer mitochondrial membrane. These results strongly suggest that the inhibition of oxidative phosphorylation by fusaramin is predominantly attributable to the impairment of VDAC1 functions. Fusaramin also inhibited FoF1-ATP synthase and ubiquinol-cytochrome c oxidoreductase (complex III) at concentrations higher than those required for the VDAC inhibition. Considering that other tetramic acid derivatives are reported to inhibit FoF1-ATP synthase and complex III, natural tetramic acids were found to elicit multiple inhibitory actions against mitochondrial machineries.
Faecal Calprotectin from Ileostomy Output Is Sensitive and Specific for the Prediction of Small Bowel Inflammation in Patients with Crohn’s Disease
Authors: Daoud Nader D , Hashash Jana G , Picco Michael F , Farraye Francis A 
Published: October 2021

Abstract

Background
Severe Crohn’s disease [CD] can result in extensive bowel resections and need for creation of an ileostomy. Faecal calprotectin [FC] is well studied in CD management, though its role in patients who have an ileostomy is unclear. Our aim is to understand if FC is a useful adjunct to radiographic or endoscopic studies in identifying recurrent CD after surgery in patients with an ileostomy.

Methods
Between January 1, 2017, and September 30, 2020, we searched the Mayo Clinic electronic medical record retrospectively for adult patients with ICD-10 code for CD, and a surgical history of an ileostomy. Patients were included in the analysis if they had at least one FC measured and a concomitant radiographic imaging and/or endoscopic procedure. An abnormal FC was defined as greater than 60 µg/g.

Results
Of 51 patients who met our inclusion criteria, 17 had an FC level &gt;60 µg/g. Of these 17 patients, 14 had imaging and/or an ileoscopy confirming the presence of small bowel inflammation, with a sensitivity of 87.5%. Of the remaining 34 patients with an FC level ≤60 µg/g, 32 patients had imaging and/or ileoscopy demonstrating no small bowel inflammation, with a specificity of 91.4%. FC from an ileostomy effluent had a positive predictive value of 82.3%, a negative predictive value of 94.1% and test diagnostic accuracy of 90.1%.

Conclusion
FC from an ileostomy effluent is a highly sensitive and specific test for the assessment and monitoring of small bowel inflammation and disease recurrence in patients with CD.
An unusual case of dilated coronary sinus: case report and clinical implications
Authors: Cardi Thomas , Ohana Mickaël , Marzak Halim , Jesel Laurence 
Published: October 2021

Abstract

Background
The presence of a dilated coronary sinus (CS) assessed by transthoracic echocardiography (TTE) is highly suggestive of inferior or superior vena cava (SVC) anomalies, in the absence of a shunt. The most frequent finding is the persistence of a left superior vena cava (LSVC): well-known feature to electrophysiologists. Abnormal inferior vena cava (IVC) drainage is another cause of CS dilatation.

Case summary
An 83-year-old woman presented with heart failure symptoms, atrial fibrillation with rapid ventricular rate, and a dilated CS assessed by TTE. Atrioventricular (AV) node ablation was considered given the poor efficacy of a rate control strategy. Cardiac computed tomography (CT) revealed a double SVC with an LSVC draining directly into the dilated CS. Single-lead pacemaker implantation was performed using a right-sided vascular access with no technical difficulties. An aborted AV node ablation procedure was due to the impossibility of getting to the right atrium. Fluoroscopy and CT imaging at second look analysis confirmed the diagnosis of an abnormal IVC with an agenesia of its supra-hepatic segment directly drained into the CS.

Discussion
Our clinical case illustrates an unusual and rare double venous abnormality: both LSVC and IVC directly drained into the CS and were responsible for its massive dilatation.
Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence
Authors: Fu Ci , Beattie Sarah R , Jezewski Andrew J , Robbins Nicole , Whitesell Luke , Krysan Damian J , Cowen Leah E 
Published: October 2021

Abstract
The opportunistic human fungal pathogen Cryptococcus neoformans has tremendous impact on global health, causing 181,000 deaths annually. Current treatment options are limited, and the frequent development of drug resistance exacerbates the challenge of managing invasive cryptococcal infections. In diverse fungal pathogens, the essential molecular chaperone Hsp90 governs fungal survival, drug resistance, and virulence. Therefore, targeting this chaperone has emerged as a promising approach to combat fungal infections. However, the role of Hsp90 in supporting C. neoformans pathogenesis remains largely elusive due to a lack of genetic characterization. To help dissect the functions of Hsp90 in C. neoformans, we generated a conditional expression strain in which HSP90 is under control of the copper-repressible promoter CTR4-2. Addition of copper to culture medium depleted Hsp90 transcript and protein levels in this strain, resulting in compromised fungal growth at host temperature; increased sensitivity to stressors, including the azole class of antifungals; altered C. neoformans morphology; and impaired melanin production. Finally, leveraging the fact that copper concentrations vary widely in different mouse tissues, we demonstrated attenuated virulence for the CTR4-2p-HSP90 mutant specifically in an inhalation model of Cryptococcus infection. During invasion and establishment of infection in this mouse model, the pathogen is exposed to the relatively high copper concentrations found in the lung as compared to blood. Overall, this work generates a tractable genetic system to study the role of Hsp90 in supporting the pathogenicity of C. neoformans and provides proof-of-principle that targeting Hsp90 holds great promise as a strategy to control cryptococcal infection.
Effect of Parenteral Energy or Amino Acid Doses on In-Hospital Mortality Among Patients With Aspiration Pneumonia: A Cohort Medical Claims Database Study
Authors: Maeda Keisuke , Murotani Kenta , Kamoshita Satoru , Horikoshi Yuri , Kuroda Akiyoshi 
Published: October 2021

AbstractBackgroundThis study examined the association between parenteral energy/amino acid doses and in-hospital mortality among inpatients on long-term nil per os (NPO) status, using a medical claims database in Japan.MethodsHospitalized patients with aspiration pneumonia, aged 65 and older, and on more than 7-day NPO status were identified in a medical claims database between January 2013 and December 2018. Using multivariate logistic regression and regression analyses, we examined the association between mean parenteral energy/amino acid doses and in-hospital mortality, and secondarily, the association between prognosis (in-hospital mortality, inability to receive full oral intake, readmission, and hospital stay length) and 4 groups of mean amino acid doses (no dose: 0 g/kg/day; very low dose: &gt;0, ≤0.3 g/kg/day; low dose: &gt;0.3, ≤0.6 g/kg/day; moderate dose: &gt;0.6 g/kg/day).ResultsThe analysis population included 20 457 inpatients (≥80 years: 78.3%). In total, 5 920 mortalities were recorded. Increased amino acid doses were significantly associated with reduced in-hospital mortality (p &lt; .001). With a no dose reference level, the odds ratios (95% confidence interval) of in-hospital mortality adjusted for potential confounders were 0.78 (0.72–0.85), 0.74 (0.67–0.82), and 0.69 (0.59–0.81) for very low, low, and moderate amino acid doses, respectively. Additionally, patients prescribed amino acid dose levels more than 0.6 g/kg/day had shorter hospitalization periods than those prescribed none.ConclusionsIncreased amino acid doses were associated with reduced in-hospital mortality. Sufficient amino acid administration is recommended for patients with aspiration pneumonia requiring NPO status.
The Impact of Aging Policy on Societal Age Stereotypes and Ageism
Authors: Ng Reuben , Chow Ting Yu Joanne , Yang Wenshu 
Published: October 2021

AbstractBackground and ObjectivesWhile studies have researched ageism in public policy, few investigated the impact of aging policy on ageism—typically, an unintended consequence. Ageism is linked to $63 billion in health care costs, so its antecedents are of interest. We test the association between Aging Policy Agenda Setting and Societal Age Stereotypes and hypothesize a mediating pathway via Medicalization of Aging, moderated by demographics.Research Design and MethodsScholars identified Singapore’s Pioneer Generation Policy (PGP) as one of the largest policy implementations in recent years, where the agenda was set by the Prime Minister at an equivalent State of the Union address in 2013, and US$7 billion allocated to fund outpatient health care costs for aged 65 years or older. More than 400,000 older adults received a PGP card and home visits by trained volunteers who co-devised a personalized utilization plan. We leveraged a 10-billion-word data set with more than 30 million newspaper and magazine articles to dynamically track Societal Age Stereotype scores over 8 years from pre- to postpolicy implementation.ResultsSocietal Age Stereotypes followed a quadratic trend: Prior to the Aging Policy Agenda Setting from 2010 to 2014, stereotypes were trending positive; after 2014, it trended downward to become more negative. Medicalization of Aging mediated the relationship between Aging Policy Agenda Setting and Societal Age Stereotypes. Furthermore, Old-age Support Ratio moderated the mediational model, suggesting that the impact of policy on medicalization is stronger when a society is more aged.Discussion and ImplicationsWe provided a framework for policymakers to ameliorate the unintended consequences of aging policies on societal ageism—if unaddressed, it will exert an insidious toll on older adults, even if initial policies are well-intentioned.