bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motion‐robust quantitative multiparametric brain MRI with motion‐resolved MR multitasking
Authors: Ma Sen , Wang Nan , Xie Yibin , Fan Zhaoyang , Li Debiao , Christodoulou Anthony G. 
Published: August 2021

PurposeTo address head motion in brain MRI with a novel motion‐resolved imaging framework, with application to motion‐robust quantitative multiparametric mapping.MethodsMR multitasking conceptualizes the underlying multiparametric image in the presence of motion as a multidimensional low‐rank tensor. By incorporating a motion‐state dimension into the parameter dimensions and introducing unsupervised motion‐state binning and outlier motion reweighting mechanisms, the brain motion can be readily resolved for motion‐robust quantitative imaging. A numerical motion phantom was used to simulate different discrete and periodic motion patterns under various translational and rotational scenarios, as well as investigate the sensitivity to exceptionally small and large displacements. In vivo brain MRI was performed to also evaluate different real discrete and periodic motion patterns. The effectiveness of motion‐resolved imaging for simultaneous T1/T2/T1ρ mapping in the brain was investigated.ResultsFor all 14 simulation scenarios of small, intermediate, and large motion displacements, the motion‐resolved approach produced T1/T2/T1ρ maps with less absolute difference errors against the ground truth, lower RMSE, and higher structural similarity index measure of T1/T2/T1ρ measurements compared to motion removal, and no motion handling. For in vivo experiments, the motion‐resolved approach produced T1/T2/T1ρ maps with the best image quality free from motion artifacts under random discrete motion, tremor, periodic shaking, and nodding patterns compared to motion removal and no motion handling. The proposed method also yielded T1/T2/T1ρ measurement distributions closest to the motion‐free reference, with minimal measurement bias and variance.ConclusionMotion‐resolved quantitative brain imaging is achieved with multitasking, which is generalizable to various head motion patterns without explicit need for registration‐based motion correction.
Cross‐cultural adaptation and validation of the neurogenic bladder symptom score for Spanish speakers
Authors: Moreno‐Palacios J. , Castro‐Nuñez P. , Padilla‐Fernández B. , Beltran‐Martinez L. , Katz‐Nestor O. , Braschi Emmanuel , Garrido G. 
Published: August 2021

AbstractAimTo perform a cross‐cultural adaptation and validation of the Neurogenic Bladder Symptom Score (NBSS) to Spanish in patients with neurogenic lower urinary tract dysfunction.Materials and MethodsThe questionnaire was culturally adapted according to international guidelines. It was applied, twice in a range of 14–28 days. Psychometric properties were tested such as content validity, construct validity, internal consistency, and test–retest reliability.ResultsA total of 82 patients between 18 and 78 years old (mean age of 43.9) participated in the study, and completed the first NBSS assessment; only 39 (32.19%) performed the test–retest study. The internal consistency was tested by Cronbach α with a result of 0.86 (95% CI, 0.81–0.90). The reliability was tested by interclass correlation coefficient with a result of 0.91 [0.87–0.95] (p < 0.0001). The construct validity was tested by Pearson correlation between NBSS and Qualiveen‐SF, which showed a moderate correlation with a result of 0.57 (p < 0.0001). One‐way analysis of variance with trend analysis demonstrated that patients who reported having a more severe problem with their bladder function had a higher NBSS total score (p < 0.001).ConclusionThe results of this study demonstrated that the Spanish version of the NBSS has a good internal consistency and reliability, proving its applicability.
D‐dimer level for ruling out peripherally inserted central catheter‐associated upper extremity deep vein thrombosis and superficial vein thrombosis
Authors: Liu Wanli , He Lianxiang , Zeng Wenjing , Yue Liqing , Wei Jie , Zeng Shuangshuang , Wang Xiang , Gong Zhicheng 
Published: August 2021

AbstractAimsTo examine the effectiveness of D‐dimer values to be used as an independent diagnostic marker for excluding peripherally inserted central catheter‐associated upper extremity deep vein thrombosis and superficial vein thrombosis.DesignThis was a retrospective case–cohort study.MethodsRecords were reviewed for 281 patients who underwent peripherally inserted central catheter insertion between 1 October 2017 and 1 October 2019. According to the modified Wells score after peripherally inserted central catheter insertion, the patients who had low vein thrombosis risk underwent a D‐dimer test and colour Doppler ultrasound.ResultsAmong 281 patients, 180 patients (64%, 95% CI: 58.2%–69.4%) had negative D‐dimer results and 39 of 180 patients had vein thrombosis despite having a negative D‐dimer result, resulting in a failure rate of 21.7% (95% CI: 16.3%–28.3%). The negative predictive value of peripherally inserted central catheter‐associated vein thrombosis in the cancer group (80.0%, 95% CI: 73.2%–85.4%) was higher than that of the non‐cancer group (60.0%, 95% CI: 35.7%–80.2%). The negative predictive value of peripherally inserted central catheter‐associated deep venous thrombosis (84.9%, 95% CI: 78.7%–89.6%) was lower than that of the PICC‐associated superficial venous thrombosis (91.0%, 95% CI: 85.4%–94.6%).ConclusionThe D‐dimer levels maybe should not be used as a diagnostic index to rule out peripherally inserted central catheter‐associated upper extremity vein thrombosis.
Iterative learning control for linear parabolic distributed parameter systems with multiple point sensors
Authors: Liu Yaqiang , Lai Jialun , Jin Zengwang , Ren Zhigang , Xie Shengli , Wang Yalin 
Published: August 2021

AbstractThis article presents an iterative learning control (ILC) approach for linear parabolic distributed parameter systems with multiple actuators and multiple sensors. The distribution functions of actuators and sensors are chosen as delta function to produce pointwise control and pointwise measurement. A P‐type ILC law is proposed based on the iterative inputs and outputs to ensure the iterative process of the system is convergent under the ILC law. By utilizing integration by parts, triangle inequality, property of delta function, and Gronwall lemma, a sufficient condition based on an inequality constraint for the convergence analysis of the track error system is presented. Finally, the effectiveness of the proposed design method is verified by numerical simulation results.
Successful Treatment of Afatinib Reversing Epidermal Growth Factor ReceptorExon19Deletion/G724S MutationResistance Guided byProtein-DrugDocking
Authors: Yu Nian , Xu Yinghui , Wang Xu , Sun Chao , Qiu Shi , Guo Ye , Bai Miao , Huang Yanxin , Ma Kewei 
Published: August 2021

AbstractG724S is a rare mutation induced by different generations of tyrosine kinase inhibitors (TKIs). No clinical effective drugs toward G724S mutation have been reported till now. We analyzed the interaction of three drugs (afatinib, gefitinib, osimertinib) with epidermal growth factor receptor (EGFR) from three aspects: the spatial structure of the binding region, the scoring function value, and the interaction force between drug molecules and active center of EGFR. Our results indicate that afatinib remains effective to patients with EGFR Exon19Deletion(Ex19Del) and G724S mutations whereas osimertinib and gefitinib are not, which is consistent with other reports. Afatinib is reported to be effective against G724S mutation, but no long-term clinical survival has been reported till now. A patient with stage IV adenocarcinoma was found to have Ex19Del/G724S mutation. Treated with afatinib, he received a progression-free survival of more than 1 year. With the guidance of this case report, we provide the clinical evidence of using afatinib for patients with G724S mutations and obtaining long-term clinical survival.Key Points
Development of meniscus‐inspired 3D‐printed PCL scaffolds engineered with chitosan/extracellular matrix hydrogel
Authors: Asgarpour Rahil , Masaeli Elahe , Kermani Shabnam 
Published: August 2021

AbstractMeniscus injuries, usually caused by tears or degenerative processes, impair normal knee function and lead to advanced osteoarthritis. Therefore, with the aim of restoring the normal meniscus function, replacement strategies based on tissue engineering strategies have gained prominence alongside other therapeutic endeavors. Regarding heterogeneity of natural meniscus tissue, ideal scaffold in meniscal engineering should mimic tissue with regard to both tissue architecture and biochemical composition. In this research, polycaprolactone (PCL) scaffolds with different strand spaces were firstly designed and fabricated through 3D‐printing process to provide a template and structural support for meniscus regeneration. According to results of physical and mechanical characterizations, 3D‐printed scaffolds with strand space of 0.2 mm were modified with chitosan hydrogel containing decellularized meniscus to recapitulate the structure and composition of meniscus extracellular matrix (ECM). The electron microscopy and infrared spectroscopy results demonstrated the successful biomimetic coating of chitosan/ECM hydrogel on scaffolds that subsequently promoted the metabolic activity of cultured human adipose derived stem cells (hASCs). qPCR analysis of ACAN, SOX9, COLL2, and COLL1A1 genes indicated the ability of the biomimetic coating to induce fibrocartilage phenotype in seeded cells. These results were exciting for application in tissue engineering as 3D‐printed scaffolds provide a unique template for meeting structural challenges in meniscus replacement.
Safety of administration of BNT162b2 mRNA (Pfizer‐BioNTech) COVID‐19 vaccine in youths and young adults with a history of acute lymphoblastic leukemia and allergy to PEG‐asparaginase
Authors: Mark Catherine , Gupta Sumit , Punnett Angela , Upton Julia , Orkin Julia , Atkinson Adelle , Clarke Lindsay , Heisey Alice , McGovern Christine , Alexander Sarah 
Published: August 2021

AbstractVaccinationis a critical tool in the prevention of COVID‐19 infection for individuals and for communities. The mRNA vaccines contain polyethylene glycol (PEG) as a stabilizer. Currently, in North America, only the BNT162b2 (Pfizer‐BioNTech) mRNA vaccine is approved for individuals aged 12–17. Most patients treated with contemporary regimens for acute lymphoblastic leukemia receive PEG‐asparaginase (PEG‐ASNase) and 10%–30% will develop allergic reactions. Optimizing access and safety for vaccine administration for these patients is critical. This report describes a process developed to support COVID vaccination in a cohort of adolescents and young adults with a history of PEG‐ASNase allergy.
A retrospective study of electroencephalography burst suppression in children undergoing general anesthesia
Authors: Gao Zhengzheng , Zhang Jianmin , Wang Xiaoxue , Yao Mengnan , Sun Lan , Ren Yi , Qiu Dongyu 
Published: August 2021

ABSTRACTImportanceIn children, anesthesia dosages are based on population pharmacokinetics and patient hemodynamics rather than patient‐specific brain activity. Brain function is highly susceptible to the effects of anesthetics.ObjectiveThe primary objective of this retrospective pilot study was to assess the prevalence of electroencephalography (EEG) burst suppression—a sign of deep anesthesia—in children undergoing general anesthesia.MethodsWe analyzed EEG in patients aged 1–36 months who received sevoflurane or propofol as the primary anesthetic. Patient enrollment was stratified into two age groups: 1–12 months and 13–36 months. Burst suppression (voltage ≤ 5.0 mV, lasting > 0.5 seconds) was characterized by occurrence over anesthesia time. Associations with patient demographics and anesthetics were determined.ResultsIn total, 54 patients (33 males and 21 females) were included in the study [age 11.0 (5.0–19.5) months; weight 9.2 (6.5–11.0) kg]. The total prevalence of burst suppression was 56% (30/54). Thirty‐three percent of patients experienced burst suppression during the surgical phase. The greatest proportion of burst suppression occurred during the induction phase. More burst suppression event occurrences (18/30) were observed in the patient under sevoflurane anesthesia (P = 0.024). Virtually all patients who received propofol boluses had burst suppression (P = 0.033). More burst suppression occurred in patients with hypotension (P < 0.001). During the surgical phase, a younger age was associated with more burst suppression (P = 0.002).InterpretationEEG burst suppression was associated with younger age, inhalation anesthetics, propofol bolus, and lower arterial pressure.
Calibration of cavity pressure simulation using autoencoder and multilayer perceptron neural networks
Authors: Huang Ming‐Shyan , Liu Chun‐Yin , Ke Kun‐Cheng 
Published: August 2021

AbstractNumerical simulations of polymer melt flow behavior in cavities help predict and optimize injection molding process parameters. However, simulation and actual results may differ because of simplified mathematical models, inaccurate processing conditions, material property settings, and machine aging, among other factors. Therefore, simulated optimal process parameters cannot be directly applied in practice. This study applied machine learning to generate a virtual–actual correction model to improve the accuracy of simulation results, especially the cavity pressure profile, a key indicator of injection‐molding quality for identifying ideal process parameter settings such as filling‐to‐packing switchover time and holding pressure. This method does not require big data for model training to enhance its practicality. Therefore, the correction model is only suitable for specific settings. A set of injection molding machines, molds, and processed materials were used for experimental verification. An autoencoder model was used to extract the features of simulation and actual cavity pressure curves. Then, a multilayer perceptron model was used to determine a relationship between simulation and actual features. The autoencoder was used to decode simulated features into cavity pressure curves. The proposed method was verified with dumbbell‐shaped specimens; the correlation between simulated and actual cavity pressures was greatly improved from 81% to 98%.
A novel technique for the development of acetabular cup by cold isostatic compaction and sintering of UHMWPE powder with optimized processing parameters
Authors: Jana Ashirbad , Selvaraj Senthilvelan , Subramani Kanagaraj 
Published: August 2021

AbstractLife of a metal on ultra‐high molecular weight polyethylene (UHMWPE) total hip replacement is often limited to 10–15 years, due to wear loss and aseptic loosening. Due to its high melt flow index, UHMWPE is typically processed by ram extrusion or compression molding technique, but yet to be processed to the full potential of its mechanical integrity in acetabular shape without any fusion defects or weak bonding. The main objective of the present study is to develop a novel technique to fabricate defect‐free acetabular cups with desired bearing characteristics and surface finish by sintering medical‐grade UHMWPE GUR 1050 powder after its cold isostatic compaction with optimum processing parameters. Sintering kinetics of UHMWPE is studied comprehensively using a thermomechanical analyzer. The influence of compaction pressure, sintering temperature, and sintering duration on sintering kinetics of UHMWPE is explored to realize their optimum. The optimally processed UHMWPE has the relative density of 97% and Vickers hardness of 5.4 with tensile yield strength and elastic modulus of 21.5 and 625 MPa, respectively. The newly developed acetabular cup exhibited inherent plateau‐finished bearing surface with an average surface roughness of <100 nm, having good bearing characteristics and desired dimension.
New method for controlled synthesis of polylactide block copolymers: organoborane/p‐quinone system and reversible‐deactivation radical polymerization
Authors: Ludin Dmitrii V , Zaitsev Sergey D , Markin Alexey V , Grishin Ivan D , Sologubov Semen S , Kovylina Tatyana A , Fedushkin Igor L 
Published: August 2021

AbstractWe developed a new approach to obtain polylactide hybrid block copolymers with vinyl monomers (styrene, methyl methacrylate, methyl acrylate) through the realization of a reaction sequence using triethylborane and various p‐quinones. The method offered includes two stages. In the first stage, a chain‐transfer agent was obtained by borylation of the terminal hydroxyl groups of polylactide. The second stage was vinyl monomer radical polymerization in the presence of p‐quinone accompanied by SH2‐substitution at the boron atom.1,4‐Naphthoquinone, 2,3‐dimethyl‐1,4‐benzoquinone, duroquinone and 2,5‐di‐tert‐butyl‐1,4‐benzoquinone were used as synthetic polymer chain growth mediators. It is shown that 1,4‐naphthoquinone and 2,3‐dimethyl‐1,4‐benzoquinone, similar in their characteristics, are effective agents providing the realization of reversible‐deactivation radical polymerization. Realization of reversible‐deactivation radical polymerization was proved with the analysis of the kinetics of block copolymerization, molecular weight characteristics and compositional homogeneity of block copolymers as well as its further capability to elongate the polymer chain. Synthesized block copolymers have a high thermal stability compared to the initial borylated polylactide. © 2021 Society of Industrial Chemistry.
Educator perspectives on mental health resources and practices in their school
Authors: Ormiston Heather E. , Nygaard Malena A. , Heck Olivia C. , Wood Maureen , Rodriguez Nicole , Maze Mallory , Asomani‐Adem Akua A. , Ingmire Keelyn , Burgess Bri , Shriberg David 
Published: August 2021

AbstractThe need for mental health services in schools is increasing. Teachers are expected to meet student's academic needs but may find their role impacted by the need for mental health support among students (Bruhn et al., 2014; Kaffenberger & O'Rouke‐Trigiani, 2013). The purpose of this study is to elicit teacher perspectives on addressing the mental health needs of students in school. Staff members from one school in a Midwestern state were interviewed to examine their perspectives related to student mental health. Thirteen classroom teachers (n = 13), four related arts teachers (n = 4), seven special education staff members (n = 7), three building support personnel (n = 3), two office staff (n = 2), and four support staff members (n = 4) were interviewed, for a total of 33 participants (n = 33). Participant experience ranged from 2 to 37 years in education. Utilizing an inductive thematic analysis approach (Braun & Clarke, 2006), information regarding teachers' current knowledge of, roles, and approaches to support students with mental health needs in schools is presented across four main themes. Directions for future research, training, and practice are described.
Oral RNAi toxicity assay suggests clathrin heavy chain as a promising molecular target for controlling the 28‐spotted potato ladybird, Henosepilachna vigintioctopunctata
Authors: Guo Mujuan , Nanda Satyabrata , Chen Shimin , Lü Jing , Yang Chunxiao , Liu Zhuoqi , Guo Wei , Qiu Baoli , Zhang Youjun , Zhou Xuguo , Pan Huipeng 
Published: August 2021

AbstractBACKGROUNDUse of RNA interference (RNAi) technology in effective pest management has been explored for decades. Henosepilachna vigintioctopunctata is a major solanaceous crop pest in Asia. In this study, the effects of the RNAi‐mediated silencing of clathrin heavy chain in H. vigintioctopunctata were investigated.RESULTSFeeding either the in vitro‐synthesized or the bacterially expressed double‐stranded RNAs (dsRNAs) significantly impaired the normal physiology of H. vigintioctopunctata instars and adults. However, the bacterially expressed dsHvChc caused higher mortality than the in vitro‐synthesized ones in the larvae and adults. Moreover, on evaluating the potential risk of dsHvChc on Propylea japonica, significant transcriptional effects of dsHvChc1 were observed, while the organismal level effects were not significant. On the contrary, dsHvChc2 did not affect P. japonica at either level. A similar test revealed significant transcriptional effects of dsPjChc1 on H. vigintioctopunctata, while staying ineffective at the organismal levels. Conversely, dsPjChc2 did not affect H. vigintioctopunctata at either level. Importantly, no effect of dsPjChc1 exposure on H. vigintioctopunctata suggested that other factors besides the 21‐nucleotide (nt) matches between sequences were responsible. Finally, ingestion of dsHvmChc1 derived from H. vigintioctomaculata, containing 265‐nt matches with dsHvChc1, caused 100% mortality in H. vigintioctopunctata.CONCLUSIONSWe conclude that (i) species with numerous 21‐nt matches in homologous genes are more likely to be susceptible to dsRNA; (ii) dsRNA can be safely designed to avoid negative effects on non‐target organisms at both transcriptional and organismal levels; (iii) HvChc can be used as an efficient RNAi target gene to effectively manage H. vigintioctopunctata. © 2021 Society of Chemical Industry.
Quantized feedback control for Markovian jumping singular systems driven by fractional Brownian motions
Authors: Xie Jing , Meng Jing , Kao Yonggui , Liu Zhen 
Published: August 2021

AbstractThe quantized feedback control for a type of delayed Markovian jumping singular systems driven by fractional Brownian motions is investigated. Firstly, the input is quantized by a uniform operator consisting of a linear part to deal with system stochastic stability and a nonlinear part to deal with the error caused by the quantizer. Secondly, to deal with the boundedness of fractional Brownian motions, a new type of Lyapunov function dependent of Hurst index is constructed. Then, utilizing generalized Finsler lemma and Gronwall inequality, some new criteria on the singular stochastic finite‐time boundedness are obtained for the considered systems with the designed quantized input. Finally, a numerical example and a DC motor example are presented to verify the effectiveness of the proposed methods and results.
Predicting rootzone soil moisture from surface observations in cropland using an exponential filter
Authors: Rossini Pedro , Patrignani Andres 
Published: August 2021

AbstractRootzone soil moisture provides valuable information to guide in‐season management decisions in rainfed and irrigated agricultural systems. Measuring rootzone soil moisture usually requires the deployment of a vertical array of sensors, which can be costly and labor intensive. In this study, we tested the skill of an exponential filter to estimate rootzone soil moisture conditions from a time series of near‐surface soil moisture observations. Daily soil moisture observations from a sensor at 10‐cm depth were used to predict the soil water content at 30‐, 50‐, and 70‐cm depth, and across the entire soil profile (0‐to‐80‐cm depth) in four agricultural fields under irrigated and rainfed conditions. The characteristic time length was the only fitting parameter of the model, which was optimized for each site based on the Nash–Sutcliffe (NS) score. Across the four sites, the mean NS score at individual soil layers ranged from −0.64 to 0.73, but the NS score at the profile level ranged between 0.29 and 0.84. Predictions of soil water storage at the profile level based on near‐surface soil moisture and the exponential filter resulted in average RMSE of 11 mm across the four locations. Our study shows that in agricultural fields the exponential filter performs better when considering the entire soil profile rather than individual soil layers.