bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preterm birth, stillbirth and early neonatal mortality during the Danish COVID-19 lockdown
Authors: Hedley Paula L. , Hedermann Gitte , Hagen Christian M. , Bækvad-Hansen Marie , Hjalgrim Henrik , Rostgaard Klaus , Laksafoss Anna D. , Hoffmann Steen , Jensen Jørgen Skov , Breindahl Morten , Melbye Mads , Hviid Anders , Hougaard David M. , Krebs Lone , Lausten-Thomsen Ulrik , Christiansen Michael 
Published: November 2021

AbstractUsing provisional or opportunistic data, three nationwide studies (The Netherlands, the USA and Denmark) have identified a reduction in preterm or extremely preterm births during periods of COVID-19 restrictions. However, none of the studies accounted for perinatal deaths. To determine whether the reduction in extremely preterm births, observed in Denmark during the COVID-19 lockdown, could be the result of an increase in perinatal deaths and to assess the impact of extended COVID-19 restrictions, we performed a nationwide Danish register-based prevalence proportion study. We examined all singleton pregnancies delivered in Denmark during the COVID-19 strict lockdown calendar periods (March 12–April 14, 2015-2020, N = 31,164 births) and the extended calendar periods of COVID-19 restrictions (February 27–September 30, 2015-2020, N = 214,862 births). The extremely preterm birth rate was reduced (OR 0.27, 95% CI 0.07 to 0.86) during the strict lockdown period in 2020, while perinatal mortality was not significantly different. During the extended period of restrictions in 2020, the extremely preterm birth rate was marginally reduced, and a significant reduction in the stillbirth rate (OR 0.69, 0.50 to 0.95) was observed. No changes in early neonatal mortality rates were found.Conclusion: Stillbirth and extremely preterm birth rates were reduced in Denmark during the period of COVID-19 restrictions and lockdown, respectively, suggesting that aspects of these containment and control measures confer an element of protection. The present observational study does not allow for causal inference; however, the results support the design of studies to ascertain whether behavioural or social changes for pregnant women may improve pregnancy outcomes.

What is Known:• The aetiologies of preterm birth and stillbirth are multifaceted and linked to a wide range of socio-demographic, medical, obstetric, foetal, psychosocial and environmental factors.• The COVID-19 lockdown saw a reduction in extremely preterm births in Denmark and other high-income countries. An urgent question is whether this reduction can be explained by increased perinatal mortality.

What is New:• The reduction in extremely preterm births during the Danish COVID-19 lockdown was not a consequence of increased perinatal mortality, which remained unchanged during this period.• The stillbirth rate was reduced throughout the extended period of COVID-19 restrictions.
Circular RNA screening identifies circMYLK4 as a regulator of fast/slow myofibers in porcine skeletal muscles
Authors: Cao Haigang , Liu Jieming , Du Tianning , Liu Yihao , Zhang Xiaoyu , Guo Yuan , Wang Jie , Zhou Xiaomin , Li Xiao , Yang Gongshe , Shi Xin’e 
Published: November 2021

AbstractThe type of myofiber is related to the quality of meat. The slow oxidized myofiber helps to increase the tenderness and juiciness of muscle. Numerous studies have shown that circRNA plays a key role in skeletal muscle development. However, the role of circRNA in porcine skeletal myofiber types is unclear. In this study, we performed high-throughput RNA sequencing to study the differential expression of circRNA in the longissimus dorsi and the soleus muscle. A total of 40,757 circRNAs were identified, of which 181 were significantly different. Interestingly, some circRNAs were involved in metabolism pathways, AMPK, FoxO, and PI3K-Akt signaling pathways. Besides, we focused on a novel circRNA-circMYLK4. By injecting circMYLK4-AAV into piglets, we found that circMYLK4 significantly increased the mRNA and protein levels of the slow muscle marker genes. In summary, our study laid an essential foundation for further research of circRNA in myofiber type conversion and higher meat quality.
Contributing to Historical-Structural Injustice via Morally Wrong Acts
Authors: Page Jennifer M. 
Published: November 2021

AbstractAlasia Nuti’s important recent book, Injustice and the Reproduction of History: Structural Inequalities, Gender and Redress (2019), makes many persuasive interventions. Nuti shows how structural injustice theory is enriched by being explicitly historical; in theorizing historical-structural injustice, she lays bare the mechanisms of how the injustices of history reproduce themselves. For Nuti, historical-structural patterns are not only shaped by habitual behaviors that are or appear to be morally permissible, but also by individual wrongdoing and wrongdoing by powerful group agents like states. In this article, I extend Nuti’s rich analysis, focusing on two questions that arise from her theory of historical-structural injustice: (1) Beyond being blameworthy for wrongful acts themselves, are culpable wrongdoers blameworthy for contributing to structural injustice? (2) Does historical moral ignorance mitigate moral responsibility for past injustice? Regarding (1), I distinguish between the local and societal structural effects of wrongdoing. Though I think this distinction is well-founded, it ultimately leads to tensions with structural injustice theory’s idea of ordinary individuals being blameless for reproducing unjust structures. Regarding (2), I argue that even though it is natural for the question of historical moral ignorance to arise in considering past wrongdoing, at least in the case of powerful group agents, we should not overlook forms of cruelty which present-day moral concepts are not needed to condemn.
Complex eco-evolutionary dynamics induced by the coevolution of predator–prey movement strategies
Authors: Netz Christoph , Hildenbrandt Hanno , Weissing Franz J. 
Published: November 2021

AbstractThe coevolution of predators and prey has been the subject of much empirical and theoretical research that produced intriguing insights into the interplay of ecology and evolution. To allow for mathematical analysis, models of predator–prey coevolution are often coarse-grained, focussing on population-level processes and largely neglecting individual-level behaviour. As selection is acting on individual-level properties, we here present a more mechanistic approach: an individual-based simulation model for the coevolution of predators and prey on a fine-grained resource landscape, where features relevant for ecology (like changes in local densities) and evolution (like differences in survival and reproduction) emerge naturally from interactions between individuals. Our focus is on predator–prey movement behaviour, and we present a new method for implementing evolving movement strategies in an efficient and intuitively appealing manner. Throughout their lifetime, predators and prey make repeated movement decisions on the basis of their movement strategies. Over the generations, the movement strategies evolve, as individuals that successfully survive and reproduce leave their strategy to more descendants. We show that the movement strategies in our model evolve rapidly, thereby inducing characteristic spatial patterns like spiral waves and static spots. Transitions between these patterns occur frequently, induced by antagonistic coevolution rather than by external events. Regularly, evolution leads to the emergence and stable coexistence of qualitatively different movement strategies within the same population. Although the strategy space of our model is continuous, we often observe the evolution of discrete movement types. We argue that rapid evolution, coexistent movement types, and phase shifts between different ecological regimes are not a peculiarity of our model but a result of more realistic assumptions on eco-evolutionary feedbacks and the number of evolutionary degrees of freedom.
Social capital and career planning amongst first generation and non-first generation high school and college students in Germany: a social network analysis approach
Authors: Wittner Britta , Kauffeld Simone 
Published: November 2021

AbstractAn important factor for First Generation High School students (FGS) in higher education is social capital. To highlight differences in social capital between FGS and their Non-FGS peers (NFGS) by analysing the structure of their ego-centred social networks and its’ effect on their career planning, we conducted two cross-sectional studies: on high school students during their first career planning stage and on college students at the beginning of their first semester. FGS have significantly less social capital in their networks than NFGS during school and university. Having academic supporters is associated with career planning amongst high school students, having instrumental support for career planning amongst college students.
Media negativity bias and tax compliance: experimental evidence
Authors: Fišar Miloš , Reggiani Tommaso , Sabatini Fabio , Špalek Jiří 
Published: November 2021

AbstractWe study the impact of the media negativity bias on tax compliance. Through a framed laboratory experiment, we assess how the exposure to biased news about government action affects compliance in a repeated taxation game. Subjects treated with positive news are significantly more compliant than the control group. Instead, the exposure to negative news does not prompt any significant reaction compared to the neutral condition, suggesting that participants may perceive the media negativity bias in the selection and tonality of news as the norm rather than the exception. Overall, our results suggest that biased news provision is a constant source of psychological priming and plays a vital role in taxpayers’ compliance decisions.
Identity Development and Social-Emotional Disorders During Adolescence and Emerging Adulthood: A Systematic Review and Meta-Analysis
Authors: Potterton Rachel , Austin Amelia , Robinson Lauren , Webb Hannah , Allen Karina L. , Schmidt Ulrike 
Published: November 2021

AbstractDepression, anxiety and eating disorders (“social-emotional disorders”) are common during adolescence/emerging adulthood, periods of intense identity development. Despite this, there are few reviews of existing research on the relationship between symptoms of these disorders and ongoing identity development. This study systematically reviewed, narratively synthesized and meta-analyzed longitudinal investigations of the relationship between identity synthesis/confusion and depression, anxiety and eating disorders symptoms during adolescence/emerging adulthood. Three databases (PsycInfo, Medline, Embase) were searched. Study quality was systematically appraised, findings were qualitatively synthesized and (where possible) meta-analyzed. 20 studies (55% “fair” quality, 45% “poor” quality) were identified, including 13,787 participants (54.2% female, mean age = 14.48 years, range 10–29 years). The narrative synthesis found evidence of bidirectional relationships between identity synthesis/confusion and depression, anxiety and eating disorder symptoms. Meta-analyses and meta-regressions of a sub-sample of studies (N = 9) indicated no significant associations between identity synthesis or confusion and anxiety or depression symptoms. More high-quality research is needed before firm conclusions can be drawn.
Party-related primacy effects in proportional representation systems: evidence from a natural experiment in Polish local elections
Authors: Flis Jarosław , Kaminski Marek M. 
Published: November 2021

AbstractWe study the primacy effects that occur when voters cast their votes because a candidate or party is listed first on a ballot. In the elections that we analyzed, there are three potential types of such effects that might occur when voters vote for (1) the first candidate listed on the ballot in single-member district (SMD) elections (candidate primacy); (2) the first party listed on the ballot in open-list proportional representation (OLPR) elections (party primacy); or (3) the first candidate on a party list in OLPR elections (list primacy). We estimated the party primacy effect (2) and established that there was no interaction between (2) and (3). A party primacy effect is especially difficult to estimate because parties’ positions on ballots are typically fixed in all multi-member districts (MMDs) and it is impossible to separate the first-position “bonus” from a party’s normal electoral performance. A rare natural experiment allowed us to estimate the primacy party bonus between 6.02 and 8.52% of all votes cast for the 2014 Polish local elections. We attribute the large size of such bonus to the great complexity of voting in the OLPR elections, especially the much longer ballots, voting in many simultaneous elections, and ballot design as a booklet rather than a sheet.
Predicting Fluid Flow Regime, Permeability, and Diffusivity in Mudrocks from Multiscale Pore Characterisation
Authors: Rezaeyan Amirsaman , Pipich Vitaliy , Ma Jingsheng , Leu Leon , Seemann Timo , Rother Gernot , Barnsley Lester C. , Busch Andreas 
Published: November 2021

AbstractIn geoenergy applications, mudrocks prevent fluids to leak from temporary (H2, CH4) or permanent (CO2, radioactive waste) storage/disposal sites and serve as a source and reservoir for unconventional oil and gas. Understanding transport properties integrated with dominant fluid flow mechanisms in mudrocks is essential to better predict the performance of mudrocks within these applications. In this study, small-angle neutron scattering (SANS) experiments were conducted on 71 samples from 13 different sets of mudrocks across the globe to capture the pore structure of nearly the full pore size spectrum (2 nm–5 μm). We develop fractal models to predict transport properties (permeability and diffusivity) based on the SANS-derived pore size distributions. The results indicate that transport phenomena in mudrocks are intrinsically pore size-dependent. Depending on hydrostatic pore pressures, transition flow develops in micropores, slip flow in meso- and macropores, and continuum flow in larger macropores. Fluid flow regimes progress towards larger pore sizes during reservoir depletion or smaller pore sizes during fluid storage, so when pressure is decreased or increased, respectively. Capturing the heterogeneity of mudrocks by considering fractal dimension and tortuosity fractal dimension for defined pore size ranges, fractal models integrate apparent permeability with slip flow, Darcy permeability with continuum flow, and gas diffusivity with diffusion flow in the matrix. This new model of pore size-dependent transport and integrated transport properties using fractal models yields a systematic approach that can also inform multiscale multi-physics models to better understand fluid flow and transport phenomena in mudrocks on the reservoir and basin scale.
The protective effect of manganese superoxide dismutase from thermophilic bacterium HB27 on hydrochloric acid-induced chemical cystitis in rats
Authors: Chen Nai-wen , Gao Jin-lai , Li Hai-long , Xu Hong , Wu Ling-feng , Meng Fan-guo , Chen Wei , Cao Yi-fang , Xie Wen-hua , Zhang Xiao-qin , Liu Shi-hui , Jin Jing , He Yi , Lv Jian-wei 
Published: November 2021

Abstract
Purpose
To evaluate the effects of manganese superoxide dismutase (Mn-SOD) from thermophilic bacterium HB27 (name as Tt-SOD) on chemical cystitis.

Methods
Control and experimental rats were infused by intravesical saline or hydrochloric acid (HCl) on the first day of the experiments. Saline, sodium hyaluronate (SH) or Tt-SOD were infused intravesically once a day for three consequent days. On the fifth day, the rats were weighted and sacrificed following a pain threshold test. The bladder was harvested for histological and biochemical analyses.

Results
Tt-SOD could reduce the bladder index, infiltration of inflammatory cells in tissues, serum inflammatory factors and SOD levels, mRNA expression of inflammatory factors in tissues, and increase perineal mechanical pain threshold and serum MDA and ROS levels in HCl-induced chemical cystitis. Furthermore, Tt-SOD alleviated inflammation and oxidative stress by the negative regulation of the NF-κB p65 and p38 MAPK signaling pathway.

Conclusions
Intravesical instillation of Tt-SOD provides protective effects against HCl-induced cystitis.
Environmental Drivers of Fine-Scale Predator and Prey Spatial Dynamics in Sydney Harbour, Australia, and Adjacent Coastal Waters
Authors: Niella Yuri , Smoothey Amy F. , Taylor Matthew D. , Peddemors Victor M. , Harcourt Robert 
Published: November 2021

AbstractGreater Sydney is the largest coastal city in Australia and is where bull sharks (Carcharhinus leucas) are present every summer and autumn. A decade of acoustic telemetry data was used to identify drivers of space use for bull sharks and their potential prey, according to standardised 6-h intervals using dynamic Brownian bridge movement models. Influences of environmental, physical, and biological variables on the areas of space use, location, and predator–prey co-occurrence were investigated with generalised additive mixed models. Rainfall in the catchment affected space use for all animals (i.e. teleost species and both sexes of sharks), with varying temporal responses. Male sharks responded most promptly to high rainfall moving upstream in < 1 day, followed by teleosts (2 to 7 days), and female bull sharks after 4 days. Environmental luminosity affected male shark dispersal and space use, possibly indicating use of visual cues for foraging. Physical characteristics of habitat were important factors driving spatial overlaps between predator and prey in estuarine areas. In sandy embayments < 10-m deep, males and female bull sharks overlapped with different species, whereas males and silver trevally (Pseudocaranx georgianus) co-occurred in deep holes (> 30 m). Shark size influenced overlap between sexes, with smaller females less likely to co-occur with larger males (~ 50 cm). Variability in space use suggests spatial segregation by sex and size in bull sharks, with individuals targeting similar prey, yet either in different areas or at different times, ultimately enabling them to exploit different resources when in the same habitats.
Extended family thalassemia screening as a feasible alternative method to be implemented in identifying carriers in West Java, Indonesia
Authors: Susanah Susi , Sari Nur Melani , Prihatni Delita , Sinaga Puspasari , Trisaputra Jessica Oktavianus , Rakhmilla Lulu Eva , Sribudiani Yunia 
Published: November 2021

Abstract
The thalassemia screening program in Indonesia mostly conducted sporadically. Ideal prospective screening is still limited. This study aimed to compare thalassemia screening methods using the extended family approach with and without a history of severe thalassemia and the feasibility of implementing extended family screening method. A case control study was conducted in Dr. Hasan Sadikin General Hospital Bandung with 3 generations of extended families. Data were collected from 150 subjects of 8 extended families with severe thalassemia as an index case entry and 151 subjects of 12 families with no history of thalassemia. All subjects were examined for Hb, MCV, MCH, and peripheral blood smear (PBS) as initial laboratory examinations. Subjects with MCV < 80 fL, MCH < 27 pg, and suggestive findings on PBS continued hemoglobin analysis. Carrier status was determined by definition. All subjects consented to undergo screening and voluntarily participated. The proportion of thalassemia carriers and the participation rate between the 2 groups were compared. Sixty-four of 150 (42.7%) and 16 of 151 (10.6%) carriers were identified in both the case and control group (p < 0.001). The participation rate was 42–88 vs. 23–100% (p = 0.244). The mean age was 31.9 ± 21.2 vs. 31.1 ± 20.8 years (p = 0.782). The median family size was 28.5 vs. 20 subjects per family (p = 0.245). The types of identified thalassemia carrier in both groups consisted of β-thalassemia, β-thalassemia/HbE, suspected α-thalassemia, and β-thalassemia Hb variant. All carriers continued the counseling process. The extended family method seems feasible to be implemented for thalassemia screening in West Java, Indonesia.
The war on deciduous forest: Large-scale herbicide treatment in the Swedish boreal forest 1948 to 1984
Authors: Östlund Lars , Laestander Sandra , Aurell Gerd , Hörnberg Greger 
Published: November 2021

AbstractAt the mid-twentieth century the pace of the transformation of the Swedish forest increased. New methods; large-scale clearcutting, mechanization of logging and planting of seedlings were developed. Chemicals were used to control insects and unwanted tree species. The aims of this study were to elucidate the timing, chain of events and the spatial extent of the large-scale spraying of phenoxy acids in Swedish forests and the drivers for this practice. More than 700 000 hectares of productive forest land was sprayed and the main driving force was a strong will to transform the forest into high-yield coniferous forest plantations. We conclude that; (1) the use of herbicides in forestry in Sweden was done on a very large scale in the period 1948–1984, (2) the ecosystem legacy of herbicide spraying must be investigated and (3) a homogenous cadre of like-minded professionals working across commercial companies, state agencies and universities is dangerous.
In situ stress characteristics of the NE Sichuan basin based on acoustic emission test and imaging logging
Authors: Fang Xinxin , Feng Hong 
Published: November 2021

AbstractThis study presents the distribution rule of in situ stress in the northeast Sichuan basin and its relationship with fracture. Sixty-seven sets of core samples of 21 Wells from the terrigenous clastic rock formation (Shaximiao, Qianfoya, Xujiahe) and marine carbonate formation (Jialingjiang, Leikoupo, Feixianguan) in the northeast Sichuan basin were tested by acoustic emission experiment. The in situ stress variation with the depth was established and the corresponding regression analysis was done. The horizontal principal stress direction of terrigenous clastic rock formation and marine carbonate rock formation was obtained by combining the dual diameter data of 6 wells and the imaging logging data of 3 wells. The results show that the vertical stress in the northeast of Sichuan basin has a linear relationship with the depth, and there is little difference between the vertical stress and the overburden weight of rocks. The maximum and minimum horizontal principal stress and horizontal shear stress increase with the burial depth. The divergence degree of horizontal shear stress with depth greater than 3000 m is greater than that of the stratum smaller than 3000 m. The horizontal stress plays a dominant role in the northeast Sichuan basin. With the increase in depth, the influence of tectonic stress field decreases and the vertical stress increases. Impacted by Dabashan and Qinling plate tectonic movement, the direction of in situ stress in marine carbonate strata is nearly east–west. The direction of maximum horizontal principal stress in terrigenous clastic rock formation is basically northwest–southeast. The imaging logging data show that the fracture direction is consistent with the horizontal principal stress direction, and the present in situ stress direction is favorable to the secondary reconstruction of natural fractures, and the fractures keep good opening. The distribution law of in situ stress in northeast Sichuan basin shows σH > σV > σh, indicating that the fault activity in this area is dominated by strike-slip type, the tectonic stress field is dominated by horizontal tectonic stress, in addition that the stress state is conducive to reverse fault activity.