bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Clinicopathological Characteristics Between the Anterior and Posterior Type of Squamous Cell Carcinoma of the Floor of the Mouth: The Anterior Type Is a Risk Factor for Multiple Primary Cancer
Authors: Oikawa Yu , Tanaka Kae , Ohsako Toshimitsu , Kugimoto Takuma , Kuroshima Takeshi , Hirai Hideaki , Tomioka Hirofumi , Shimamoto Hiroaki , Michi Yasuyuki , Sakamoto Kei , Ikeda Tohru , Harada Hiroyuki 
Published: June 2021

BackgroundFloor of the mouth (FOM) squamous cell carcinoma (SCC) accounts for approximately 10% of all oral SCCs. FOM SCC can be classified into the anterior and posterior types according to their site of origin, but few studies have compared these types. This study sought to clarify differences in clinicopathological characteristics between these two types.MethodsA total of 1,220 patients with oral SCC were treated at our department from January 2001 to December 2015. Among these patients, 62 had FOM SCC. The FOM SCCs were classified into two groups: the anterior type and the posterior type. The anterior and posterior types were defined by the boundary connecting the spaces between the canine and the first premolar bilaterally. We retrospectively compared the sex, age, smoking and drinking history, clinical stage, treatment, histopathological diagnosis, multiple primary cancers, and outcomes of the two groups.ResultsAmong the 62 patients, 32 had the anterior type, while 30 had the posterior type. The anterior type was found more significantly in men (p = 0.01) and individuals with a smoking history than the posterior type (p = 0.04). pN2–3 cervical lymph node metastasis was significantly more common in the anterior type than in the posterior type (p = 0.01). The median depth of invasion in the anterior type was 4 mm. Multivariate analysis showed that the anterior type was an independent risk factor for multiple primary cancer development in FOM SCC (p = 0.02). The cumulative 10-year disease-specific survival rates of the anterior and posterior types were 92.8 and 95.0%, respectively, while the overall survival rates were 65.4 and 95.0%, respectively. In the anterior type FOM SCC, a lower overall survival rate was associated with multiple primary cancers and smoking-related diseases.ConclusionSmoking cessation and adequate systemic screening for multiple primary cancers are needed to improve the prognosis of FOM SCC, particularly the anterior type.
The Application of Functional Magnetic Resonance Imaging in Type 2 Diabetes Rats With Contrast-Induced Acute Kidney Injury and the Associated Innate Immune Response
Authors: Li Yanfei , Shi Dafa , Zhang Haoran , Yao Xiang , Wang Siyuan , Wang Rui , Ren Ke 
Published: June 2021

AimsContrast-induced acute kidney injury (CI-AKI) is the third most common in-hospital acquired AKI, and its mechanism is not fully clear. Its morbidity increases among populations with chronic kidney disease (CKD), older age, diabetes mellitus (DM), and so on. Immediate and effective noninvasive diagnostic methods are lacking, so CI-AKI often prolongs hospital stays and increases extra medical costs. This study aims to explore the possibility of diagnosing CI-AKI with functional magnetic resonance imaging (fMRI) based on type 2 DM rats. Moreover, we attempt to reveal the immune response in CI-AKI and to clarify why DM is a predisposing factor for CI-AKI.MethodsA type 2 DM rat model was established by feeding a high-fat and high-sugar diet combined with streptozotocin (STZ) injection. Iodixanol-320 was the contrast medium (CM) administered to rats. Images were obtained with a SIEMENS Skyra 3.0-T magnetic resonance imager. Renal histopathology was evaluated using H&amp;E staining and immunohistochemistry (IHC). The innate immune response was revealed through western blotting and flow cytometry.ResultsBlood oxygenation level-dependent (BOLD) imaging and intravoxel incoherent motion (IVIM) imaging can be used to predict and diagnose CI-AKI effectively. The R2∗ value (r &gt; 0.6, P &lt; 0.0001) and D value (| r| &gt; 0.5, P &lt; 0.0001) are strongly correlated with histopathological scores. The NOD-like receptor pyrin 3 (NLRP3) inflammasome participates in CI-AKI and exacerbates CI-AKI in DM rats. Moreover, the percentages of neutrophils and M1 macrophages increase dramatically in rat kidneys after CM injection (neutrophils range from 56.3 to 56.6% and M1 macrophages from 48 to 54.1% in normal rats, whereas neutrophils range from 85.5 to 92.4% and M1 macrophages from 82.1 to 89.8% in DM rats).Conclusions/interpretationBOLD and IVIM-D can be effective noninvasive tools in predicting CI-AKI. The innate immune response is activated during the progression of CI-AKI and DM will exacerbate this progression.
Machine Learning for Predicting the 3-Year Risk of Incident Diabetes in Chinese Adults
Authors: Wu Yang , Hu Haofei , Cai Jinlin , Chen Runtian , Zuo Xin , Cheng Heng , Yan Dewen 
Published: June 2021

Purpose: We aimed to establish and validate a risk assessment system that combines demographic and clinical variables to predict the 3-year risk of incident diabetes in Chinese adults.Methods: A 3-year cohort study was performed on 15,928 Chinese adults without diabetes at baseline. All participants were randomly divided into a training set (n = 7,940) and a validation set (n = 7,988). XGBoost method is an effective machine learning technique used to select the most important variables from candidate variables. And we further established a stepwise model based on the predictors chosen by the XGBoost model. The area under the receiver operating characteristic curve (AUC), decision curve and calibration analysis were used to assess discrimination, clinical use and calibration of the model, respectively. The external validation was performed on a cohort of 11,113 Japanese participants.Result: In the training and validation sets, 148 and 145 incident diabetes cases occurred. XGBoost methods selected the 10 most important variables from 15 candidate variables. Fasting plasma glucose (FPG), body mass index (BMI) and age were the top 3 important variables. And we further established a stepwise model and a prediction nomogram. The AUCs of the stepwise model were 0.933 and 0.910 in the training and validation sets, respectively. The Hosmer-Lemeshow test showed a perfect fit between the predicted diabetes risk and the observed diabetes risk (p = 0.068 for the training set, p = 0.165 for the validation set). Decision curve analysis presented the clinical use of the stepwise model and there was a wide range of alternative threshold probability spectrum. And there were almost no the interactions between these predictors (most P-values for interaction &gt;0.05). Furthermore, the AUC for the external validation set was 0.830, and the Hosmer-Lemeshow test for the external validation set showed no statistically significant difference between the predicted diabetes risk and observed diabetes risk (P = 0.824).Conclusion: We established and validated a risk assessment system for characterizing the 3-year risk of incident diabetes.
Genomic Aromatic Compound Degradation Potential of Novel Paraburkholderia Species: Paraburkholderia domus sp. nov., Paraburkholderia haematera sp. nov. and Paraburkholderia nemoris sp. nov.
Authors: Vanwijnsberghe Sarah , Peeters Charlotte , De Ridder Emmelie , Dumolin Charles , Wieme Anneleen D. , Boon Nico , Vandamme Peter 
Published: June 2021

We performed a taxonomic and comparative genomics analysis of 67 novel Paraburkholderia isolates from forest soil. Phylogenetic analysis of the recA gene revealed that these isolates formed a coherent lineage within the genus Paraburkholderia that also included Paraburkholderiaaspalathi, Paraburkholderiamadseniana, Paraburkholderiasediminicola, Paraburkholderiacaffeinilytica, Paraburkholderiasolitsugae and Paraburkholderiaelongata and four unidentified soil isolates from earlier studies. A phylogenomic analysis, along with orthoANIu and digital DNA–DNA hybridization calculations revealed that they represented four different species including three novel species and P. aspalathi. Functional genome annotation of the strains revealed several pathways for aromatic compound degradation and the presence of mono- and dioxygenases involved in the degradation of the lignin-derived compounds ferulic acid and p-coumaric acid. This co-occurrence of multiple Paraburkholderia strains and species with the capacity to degrade aromatic compounds in pristine forest soil is likely caused by the abundant presence of aromatic compounds in decomposing plant litter and may highlight a diversity in micro-habitats or be indicative of synergistic relationships. We propose to classify the isolates representing novel species as Paraburkholderia domus with LMG 31832T (=CECT 30334) as the type strain, Paraburkholderia nemoris with LMG 31836T (=CECT 30335) as the type strain and Paraburkholderia haematera with LMG 31837T (=CECT 30336) as the type strain and provide an emended description of Paraburkholderia sediminicola Lim et al. 2008.
DIGITAL TECHNOLOGIES APPLICATION AS A FACTOR IN INCREASING ORGANIC MILK PRODUCTION COMPETITIVENESS
Authors: Суровцев В.Н. , Паюрова Е.Н. , Никулина Ю.Н. , Шульгин И.К. , Лужняк В.Д. , Савельев А.И. 
Published: June 2021

Рассмотрены перспективы развития органического молочного скотоводства в Российской Федерации, обусловленные вступлением в действие закона «Об органической продукции». Проанализированы факторы, способствующие развитию производства органического молока: возможность реализации эффекта масштаба, организация производства на необрабатываемых в течение ряда лет землях, свободных от остаточных проявлений интенсивной обработки, благоприятная конъюнктура внутреннего рынка, государственная поддержка экспорта. Определены основные сдерживающие факторы: отсутствие апробированных и адаптированных к региональным условиям технологий; усиление требований к качеству планирования и контроля; дефицит квалифицированных специалистов, имеющих опыт производства органической продукции; отсутствие узнаваемости бренда, негарантированность получения высокой ценовой премии. Исследованы возможности инновационных цифровых технологий в повышении производительности и результативности труда специалистов в кормопроизводстве и молочном скотоводстве, в обеспечении прослеживаемости и управляемости производственно-хозяйственного процесса в отрасли, контроля соответствия сырья и продукции требованиям к органическому производству.
The article considers the prospects for the development of organic dairy farming in the Russian Federation, due to the entry into force of the law «On Organic Products». Factors contributing to the development of organic milk production were analyzed: the possibility of realizing economies of scale, the organization of production on uncultivated lands for several years, free from residual effects of intensive processing, favorable situation on the domestic market, government support for exports. Identified the main constraints: the lack of tested and adapted to regional conditions technologies; increased requirements for quality planning and monitoring; the shortage of qualified specialists with experience in organic production; lack of brand recognition, non-guaranteed high price premium. The article explores the possibilities of innovative digital technologies to improve the productivity of specialists in fodder production and dairy farming, provide traceability and manageability of production and economic process in the industry, control of compliance of raw materials and products with the requirements for organic production.
GROWTH AND MEAT PRODUCTIVITY OF YOUNG HEREFORD BREED IN CONDITIONS OF THE SOUTH OF WESTERN SIBERIA
Authors: Тагиров Х.Х. , Николаева Н.Ю. , ИШБЕРДИНА Р.Р. 
Published: June 2021

Изучены особенности роста и продуктивные качества бычков и кастратов герефордской породы, выращенных в условиях Томской области. Исследования проводили на 2 группах животных от 15- до 24-месячного возраста. В I группу входили бычки, во II — кастраты. Средняя живая масса бычков-кастратов в начале и в конце периода исследований превосходила массу бычков I группы. Наибольший прирост живой массы с 15-месячного возраста наблюдался у бычков I группы, начиная с 20 мес, кастрированные животные показали лучшие результаты. Абсолютный ежемесячный прирост живой массы был выше в 1,5—2 раза у бычков I группы до 19 мес, после чего наблюдалась обратная тенденция. За весь период исследований от бычков I группы получен прирост живой массы в среднем 202,7 кг. Бычки-кастраты за этот же период имели прирост 210,5 кг. По показателям мясной продуктивности молодняк I группы отличался наибольшей предубойной массой, массой парной туши и убойной массой на 59,7, 20 и 10,1 кг соответственно. Бычки-кастраты превосходили сверстников I группы по содержанию внутреннего жира (на 10 кг), выходу туши (на 2,4%) и убойному выходу (на 4,7%). При изучении морфологического состава туш установлено, что бычки I группы характеризуются максимальной массой охлажденной туши. Однако по выходу мышечной ткани доминировали бычки-кастраты: содержание мякоти у них было выше на 2,2%, а индекс мясности больше на 0,4 ед.
The peculiarities of growth and productive qualities of Hereford calves and castrates raised in the Tomsk region were studied. The studies were carried out on 2 groups of animals from 15 to 24 months of age. Group I consisted of gobies, and group II consisted of castrati. The average live weight of castrate bulls at the beginning and at the end of the study period exceeded the weight of group I bulls. The greatest increase in live weight from the age of 15 months was observed in group I calves, starting from 20 months the neutered animals showed the best results. The absolute monthly increase in live weight was 1.5—2 times higher in group I bulls up to 19 months, after which the opposite trend was observed. Over the entire period of research, an average live weight gain of 202.7 kg was obtained from group I calves. Castrated gobies had an increase of 210.5 kg over the same period. According to the indicators of meat productivity, the young animals of group I had the highest pre—slaughter weight, the weight of a paired carcass and the slaughter weight by 59.7, 20 and 10.1 kg, respectively. Castrate bulls outperformed their peers in group I in terms of internal fat content (by 10 kg), carcass yield (by 2.4%), and slaughter yield (by 4.7%). When studying the morphological composition of carcasses, it was found that group I gobies are characterized by the maximum mass of the cooled carcass. However, the output of muscle tissue was dominated by castrate gobies: their pulp content was higher by 2.2%, and the meat index was higher by 0.4 units.
“Mechanical” as a MetapLot in Prokofiev's Music
Authors: Ляхович Артём 
Published: June 2021

Статья посвящена изучению звукоизобразительной сферы, связанной с образом машины, механизма, и ее отражения в музыке Прокофьева. Основной признак «механического» в музыке - ритмика ostinato, активно используемая в новоевропейской традиции, особенно в эпохи барокко и классицизма с их приоритетом ритмоэнергической стихии. В ХХ веке в контексте новых реалий сформировались «механические» ассоциации ostinato. Прокофьев - один из родоначальников традиции «механического» в музыке. Круг ассоциаций, связанный с этой традицией, имеет особое значение для его творчества благодаря приоритетной роли в нем ритмоэнергического начала и пульсации. «Механическое» у Прокофьева становится репрезентантом деперсонализации, а музыкальная ткань - полем конфликта персонализированного материала с «механическим», который можно интерпретировать как конфликт индивидуации и коллективных структур человеческого сознания.
The article is devoted to the sound-visual sphere associated with the image of a machine, mechanism, and its reflection in Prokofiev's music. The main feature of a “mechanical” in music is ostinato, which was used in European music for several centuries, especially in the Baroque and Classicism eras with their priority of the rhythmic-energy element. In the 20 century it acquired “mechanical” associations in the context of new realities. Prokofiev is one of the founders of the new tradition of “mechanical” in music. This circle of associations is of particular importance in his music due to the priority role of rhythmic-energetic beginning and pulsation in it. The “mechanical” in Prokofiev becomes a representative of depersonalization, and the musical fabric becomes a field of conflict between personalized material and “mechanical”, which can be interpreted as a conflict of individuation and the collective structures of human consciousness.
“...Against the Background of the Russian Landscape” by Roman Ledenev: Features of the CompositionaL Structure
Authors: Шмельков Семён 
Published: June 2021

Баян, имея богатую фольклорную историю и оркестровый арсенал средств музыкальной выразительности, за последние 30 лет стал одним из главных проводников идей современных композиторов во всем мире. Данная статья знакомит читателей с баянным творчеством Р. С. Леденёва (1930-2019), в частности с неоконченным циклом для баяна «...на фоне русского пейзажа» op. 50 (1996-2007). Особое внимание уделено анализу жанровой основы, мелодического и гармонического языка, композиционной техники, формы, образного строя, драматургии сочинения в контексте общих творческих ориентиров композитора, наиболее полно раскрывающихся в произведениях для хора и оркестра. В статье предлагается реконструкция условной программы цикла с учетом неоконченной третьей части.
Bayan, having a rich folklore history and an orchestral arsenal of musical expression tools, has become one of the main conductors of the ideas of modern composers around the world over the past 30 years. This article introduces readers to the bayan work of Roman Ledenev (1930-2019), namely the unfinished cycle “.against the background of the Russian landscape” ор. 50 for bayan (1996-2007). Special focus is given to the analysis of the genre basis, melodic and harmonic language, compositional technique, form formation, figurative structure, and dramaturgy of the composition in the context of the composer's general creative guidelines most fully revealed in works for chorus and orchestra. The reconstruction of the conditional program of the cycle is presented, taking into account the unfinished third part.
On the Musicality of Fiction (the Case of Nikolay Leskov's Story “Islanders”)
Authors: Чигарёва Евгения 
Published: June 2021

Статья посвящена проблеме музыкальности литературы, в частности художественной прозы. Автор, опираясь на работы Е. В. Назайкинского, рассматривает это явление на разных уровнях (фоническом, синтаксическом, композиционном). Ссылаясь на исследование крупного филолога Е. Г. Эткинда «Материя стиха», Чигарёва критически оценивает наличие в музыковедении и литературоведении (стиховедении) общих терминов, имеющих разные значения, - терминов-омонимов. Наиболее продуктивным для аналогий литературы и музыки автор считает ритм - явление, общее для двух видов искусства. В методе анализа конкретных примеров, который предлагает Чигарёва, она опирается на стиховедение, отмечая при этом различие прозы и поэзии. В качестве образца ритма художественной прозы рассматривается повесть Н. А. Лескова «Островитяне», в которой метризованная проза используется в определенных, особенно значимых моментах. Этот пример ярко демонстрирует специфику музыкальности литературы и отличие ее от музыкального искусства.
The article deals with the problem of musicality of literature, in particular, fiction. The author, based on the works of E. V. Nazaykinsky, considers this phenomenon at different levels (phonic, syntactic, compositional). Referring to a study by the major philologist E. G. Etkind “The Matter of the Verse”, Chigareva critically assesses the presence of common terms in musicology and literary studies (poetry), which have different meanings- terms-homonyms. The author considers rhythm, a phenomenon common to the two types of art, to be the most productive for analogies of literature and music. In the method of analyzing concrete examples, which Chigareva offers, she relies on poetry, while noting the difference between prose and poetry. As an example of the rhythm of artistic prose, N. S. Leskov's novel “Islanders” is proposed, in which metrized prose is used in certain, especially significant moments. This example demonstrates the specificity of musicality of literature and its difference from musical art.
Penfigoide ampolloso asociado a vildagliptina
Authors: Campbell-Silva Santiago , Calderón Franco Carlos Hernán , Marín-Castro Hailyn Andrea , Beltrán-Jaramillo Cesia Victoria , Alvis-Peña Diego Julián 
Published: June 2021

La prevalencia de diabetes tipo 2 continúa aumentando constantemente a medida que más personas viven más tiempo, y los inhibidores de la dipeptidil peptidasa-4, medicamentos orales con muy bajo riesgo de hipoglucemia y neutros con respecto al peso, se convierten en opción terapéutica para este grupo de personas mayores. No obstante, los inhibidores de la dipeptidil peptidasa-4 se han asociados con reacciones cutáneas graves entre ellas el penfigoide ampolloso, y debido a la morbilidad y mortalidad asociadas con esta afección, es necesario la sensibilización de los profesionales de la salud para que conozcan este vínculo y estar atentos ante cualquier reacción adversa cutánea de estos medicamentos en poblaciones de riesgo.
Presentamos dos casos de penfigoide ampolloso asociados a vildagliptina.
Seguridad de los anticoagulantes orales en enfermedad renal crónica avanzada
Authors: Uribe Barrada Maria Cristina , Bustamante-Trespalacios Juliana Marcela , Castro-Sánchez Susana , Arrieta-Bechara Juan Carlos 
Published: June 2021

Antecedentes: los pacientes que toman anticoagulantes orales a largo plazo y además cursan con enfermedad renal crónica (ERC), tienen mayor probabilidad de tener sangrados.
Métodos: estudio de cohorte descriptivo retrospectivo en el cual se revisaron historias clínicas de pacientes anticoagulados y con ERC 3 en adelante, atendidos en una clínica de anticoagulación con el fin de evaluar eventos hemorrágicos y características basales de la población en un periodo de dos años
Resultados: se incluyeron 238 pacientes. Los anticoagulantes usados fueron warfarina (45%), rivaroxabán (31.5%), apixabán (14.3%) y dabigatrán (3.4%). Según la clasificación KDIGO 78% de los pacientes tenían ERC G3 (37.3% G3a y 40.7% G3b), 15.9% G4 y 5.8% G5 con terapia de reemplazo renal (TRR). En el periodo de estudio solo 20 pacientes (8.4%) tuvieron eventos hemorrágicos, de estos, 7 (35%) fueron mayores (cuatro asociados a warfarina, dos rivaroxabán y uno apixabán). Los otros 13 sangrados fueron menores y asociados a warfarina en 46.1% de los casos. El sangrado digestivo fue el más frecuente (35%), seguido por tejidos blandos (30%). Sólo hubo un sangrado fatal el cual se dio en sistema nervioso central (SNC) en un paciente con ERC G4.
Conclusión: se apreció una baja tasa de sangrado, lo que podría estar relacionado con el estrecho seguimiento de una clínica de anticoagulación. El anticoagulante que más frecuentemente se asoció con sangrado fue warfarina, lo cual puede estar relacionado con un bajo tiempo en rango terapéutico (48.8%). Por la baja tasa de eventos, no fue posible la realización de comparaciones.