bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tools for integrating inertial sensor data with video bio-loggers, including estimation of animal orientation, motion, and position
Authors: Cade David E. , Gough William T. , Czapanskiy Max F. , Fahlbusch James A. , Kahane-Rapport Shirel R. , Linsky Jacob M. J. , Nichols Ross C. , Oestreich William K. , Wisniewska Danuta M. , Friedlaender Ari S. , Goldbogen Jeremy A. 
Published: August 2021

AbstractBio-logging devices equipped with inertial measurement units—particularly accelerometers, magnetometers, and pressure sensors—have revolutionized our ability to study animals as necessary electronics have gotten smaller and more affordable over the last two decades. These animal-attached tags allow for fine scale determination of behavior in the absence of direct observation, particularly useful in the marine realm, where direct observation is often impossible, and recent devices can integrate more power hungry and sensitive instruments, such as hydrophones, cameras, and physiological sensors. To convert the raw voltages recorded by bio-logging sensors into biologically meaningful metrics of orientation (e.g., pitch, roll and heading), motion (e.g., speed, specific acceleration) and position (e.g., depth and spatial coordinates), we developed a series of MATLAB tools and online instructional tutorials. Our tools are adaptable for a variety of devices, though we focus specifically on the integration of video, audio, 3-axis accelerometers, 3-axis magnetometers, 3-axis gyroscopes, pressure, temperature, light and GPS data that are the standard outputs from Customized Animal Tracking Solutions (CATS) video tags. Our tools were developed and tested on cetacean data but are designed to be modular and adaptable for a variety of marine and terrestrial species. In this text, we describe how to use these tools, the theories and ideas behind their development, and ideas and additional tools for applying the outputs of the process to biological research. We additionally explore and address common errors that can occur during processing and discuss future applications. All code is provided open source and is designed to be useful to both novice and experienced programmers.
A fresh look to the phenotype in mono-allelic likely pathogenic variants of the leptin and the leptin receptor gene
Authors: Koerber-Rosso Ingrid , Brandt Stephanie , von Schnurbein Julia , Fischer-Posovszky Pamela , Hoegel Josef , Rabenstein Hannah , Siebert Reiner , Wabitsch Martin 
Published: August 2021

AbstractLeptin (LEP) and leptin receptor (LEPR) play a major role in energy homeostasis, metabolism, and reproductive function. While effects of biallelic likely pathogenic variants (-/-) on the phenotype are well characterized, effects of mono-allelic likely pathogenic variants (wt/-) in the LEP and LEPR gene on the phenotype compared to wild-type homozygosity (wt/wt) have not been systematically investigated. We identified in our systematic review 44 animal studies (15 on Lep, 29 on Lepr) and 39 studies in humans reporting on 130 mono-allelic likely pathogenic variant carriers with 20 distinct LEP variants and 108 heterozygous mono-allelic likely pathogenic variant carriers with 35 distinct LEPR variants. We found indications for a higher weight status in carriers of mono-allelic likely pathogenic variant in the leptin and in the leptin receptor gene compared to wt/wt, in both animal and human studies. In addition, animal studies showed higher body fat percentage in Lep and Lepr wt/- vs wt/wt. Animal studies provided indications for lower leptin levels in Lep wt/- vs. wt/wt and indications for higher leptin levels in Lepr wt/- vs wt/wt. Data on leptin levels in human studies was limited. Evidence for an impaired metabolism in mono-allelic likely pathogenic variants of the leptin and in leptin receptor gene was not conclusive (animal and human studies). Mono-allelic likely pathogenic variants in the leptin and in leptin receptor gene have phenotypic effects disposing to increased body weight and fat accumulation.
Rationality in pier geometry of Kintaikyo Bridge from viewpoint of river engineering
Authors: Sato Hirokazu 
Published: August 2021

Abstract
The Kintaikyo Bridge, with its elegant wooden arches, has a unique pier shape and continues to be loved by residents and visitors alike. Although this bridge is an active footbridge and an important landscape element along with the Nishikigawa River and its river beach, the rationality or irrationality of the shape of its piers remains unknown. This paper is intended to clarify the river engineering characteristics of the piers for the first time by conducting 1/129 scale hydraulic model experiments. The shapes tested were a perfect spindle shape (which has been adopted as a common theory for many years) and a reconstructed current shape based on the spindle shape, and for comparison, an oval and a non-regular hexagon shape with the same width and area. The current shape, along with the spindle shape, suppressed the water level rise around the pier more than the others. As for the riverbed fluctuation, the current shape slightly increased the scour more than the others, but it also maximized the sedimentation around the scoured part. In other words, the current shape has the potential to facilitate the procurement of sediment for post-flood restoration. In addition, the current shape overwhelmingly reduced the statistical dispersion associated with the experiment, suggesting that it stabilizes the trend of riverbed fluctuation even during actual floods. Based on the results, the future conservation of the Kintaikyo Bridge was also discussed.
Gelidocalamus fengkaiensis (Poaceae: Bambusoideae), a new bamboo species from Guangdong, China, with an analysis of branch development in relation to flowering
Authors: Cai Zhuo-Yu , Zhou Xin-Xin , Wong Khoon-Meng , Xia Nian-He 
Published: August 2021

Abstract
Background
Bamboos, widely distributed in temperate and tropical Asia, Africa and America, refer to a group of special plants in Poaceae, Bambusoideae. China is rich in bamboo species. However, due to a long flowering cycle, the flowering habit and the flowering structure of many bamboo species are still not well understood. Here, we report a new bamboo species from Guangdong, China and an analysis of its interesting branch development in relation to flowering.

Results
This species is similar to G. stellatus, the type species, but differs in the characteristics of its lemma and palea, mid-culm branch complement, and culm-sheath ligules. The initial branches at a culm node do not apically develop flowering structures during a flowering episode; instead, these form on what appears to be specialized flowering branches.

Conclusions
The results of morphological comparison support the recognition of Gelidocalamus fengkaiensis as a new species. And during a flowering episode, two branch types (‘foliage branch’ and ‘flowering branch’) can be distinguished in this species.
Simple model for estimation of absorbed dose by organs and tumors after PRRT from a single SPECT/CT study
Authors: Chicheportiche Alexandre , Sason Moshe , Godefroy Jeremy , Krausz Yodphat , Zidan Mahmoud , Oleinikov Kira , Meirovitz Amichay , Gross David J. , Grozinsky-Glasberg Simona , Ben-Haim Simona 
Published: August 2021

Abstract
Background
Following each cycle of peptide receptor radionuclide therapy (PRRT), absorbed doses by tumors and normal organs are typically calculated from three quantitative single-photon emission computed tomography (SPECT)/computed tomography (CT) studies acquired at t1 = 24 h, t2 = 96 h, t3 = 168 h after the first cycle of treatment and from a single study at t1 after the subsequent cycles. In the present study, we have assessed the feasibility of a single SPECT/CT study after each PRRT cycle using a trained multiple linear regression (MLR) model for absorbed dose calculation and have evaluated its impact on patient management. Quantitative [177Lu]-DOTA-TATE SPECT/CT data after PRRT of seventy-two consecutive metastatic neuroendocrine tumors patients were retrospectively evaluated. A set of 40 consecutive studies was used to train the MLR model. The two independent variables of the model included the time of imaging after administration of the treatment and the radiopharmaceutical activity concentration in a given organ/tumor. The dependent variable was the dose absorbed by the organ/tumor obtained with the standard protocol. For bone marrow dosimetry, the independent variables included the time of imaging, and the blood and remainder of the body activity concentration. The model was evaluated in 32 consecutive patients. Absorbed doses were assessed for kidneys, bone marrow, liver, spleen and tumor sites.

Results
There was no difference in management decisions, whether PRRT can be safely continued or not because unsafe absorbed dose to risk organs between the standard and the MLR model-based protocol using a single SPECT/CT study performed at t3 = 168 h after the first cycle and at t1 = 24 h after the subsequent cycles. Cumulative absorbed doses were obtained with mean relative differences of − 0.5% ± 5.4%, 1.6% ± 15.1%, − 6.2% ± 7.3%, − 5.5% ± 5.8% and 2.9% ± 12.7% for kidneys, bone marrow, liver, spleen and tumors, respectively (Pearson’s r correlation coefficient 0.99, 0.91, 0.99, 0.99 and 0.97, respectively).

Conclusion
Dosimetry calculations using a MLR model with a single SPECT/CT study are in good agreement with the standard protocol, while avoiding the use of dosimetry software and enabling improved patient comfort and reduced scanner and staff time.
Inverse T-shaped sternotomy as novel thoracoplasty for severe chest deformation and tracheal stenosis
Authors: Tomita Hirofumi , Shimotakahara Akihiro , Shimojima Naoki , Ishihama Hideo , Ishikawa Miki , Mizuno Yuki , Hashimoto Makoto , Tsukizaki Ayano , Miyaguni Kazuaki , Hirobe Seiichi 
Published: August 2021

Abstract
Background
Patients with severe motor and intellectual disabilities often suffer from tracheal stenosis due to chest deformation and brachiocephalic artery compression, which sometimes leads to serious complications, such as dying spell and tracheobrachiocephalic artery fistula. We herein described our experience of performing a novel and simple thoracoplastic procedure combined with brachiocephalic artery transection in two patients with severe chest deformation and tracheal stenosis.

Case presentation
The patients were a 12-year-old female with cerebral palsy due to periventricular leukomalacia and a 21-year-old male with subacute sclerosing panencephalitis stage IV in the Jabbour classification following a laryngotracheal separation. Both patients showed severe chest deformation and symptoms of airway stenosis resulting in dying spells. The sternum was laterally transected between the manubrium and the sternal body, and a manubriotomy was performed longitudinally, ending with an inverse T-shaped sternotomy. Since the clavicle and the first rib remained attached to the halves of the divided manubrium, the sternum was allowed to be left open, resulting in improvement of the mediastinal narrowing and tracheal stenosis. Postoperative computed tomography (CT) showed that the distance between the halves of the manubrium was maintained at 10–11 mm, and that the mediastinal narrowing in both patients improved; the sternocervical spine distance increased from 20 mm to 22 and 13 mm to 16 mm, respectively. The patients’ tracheal stenosis below the sternal end of the clavicle and the manubrium and respiratory symptoms improved, and the patients are currently at home in a stable condition with no chest fragility and no upper limb movement disorder 1 year after surgery.

Conclusions
Our observations suggested that the inverse T-shaped sternotomy combined with brachiocephalic artery transection may relieve symptoms of tracheal stenosis due to severe chest deformation in patients with severe motor and intellectual disabilities.
Single-incision laparoscopic repair for an arcuate line hernia: a case report
Authors: Fukunaga Tomohiko , Kasanami Toshihiko 
Published: August 2021

Abstract
Background
The arcuate line is the inferior margin of the posterior layer of rectus abdominis sheath. An arcuate line hernia is a parietal interstitial hernia consisting of ascending protrusion of intraperitoneal contents above the arcuate line. Arcuate line hernias are rare, and fewer than 20 cases undergoing surgical repair have been reported. Various surgical approaches were used in previous cases, and there is no consensus regarding the ideal repair method. We report the first case of an arcuate line hernia repaired using single-incision laparoscopic surgery.

Case presentation
The patient was a 78-year-old man who presented with a history of intermittent lower abdominal quadrant pain of more than 2 month’s duration. He had not previously undergone abdominal surgery, but had a history of mycobacterial lung disease and asthma. His vital signs were normal on presentation, and he experienced no vomiting or nausea. On palpation, his abdomen was flat and soft, and no mass was palpable. However, there was slight tenderness in the right lower quadrant. Blood laboratory test results were within normal ranges. Computed tomography revealed small bowel protrusion between the rectus abdominis and the posterior rectus sheath, and an arcuate line hernia was suspected and subsequently confirmed intraoperatively. The patient underwent single-incision laparoscopic repair with the intraperitoneal onlay mesh technique with tacks and with care to avoid the inferior epigastric vessels. The operation time was 30 min, and no intra- or post-operative complications occurred. Surgery relieved his symptoms, with no recurrence within 1 year postoperatively.

Conclusions
Single-incision laparoscopic surgery was performed easily and successfully in this rare patient with arcuate line hernia. Arcuate line hernia should be considered in patients presenting with abdominal symptoms, and single-incision laparoscopic repair should be considered for repair.
Isoprene-degrading bacteria associated with the phyllosphere of Salix fragilis, a high isoprene-emitting willow of the Northern Hemisphere
Authors: Gibson Lisa , Crombie Andrew T. , McNamara Niall P. , Murrell J. Colin 
Published: August 2021

AbstractBackgroundIsoprene accounts for about half of total biogenic volatile organic compound emissions globally, and as a climate active gas it plays a significant and varied role in atmospheric chemistry. Terrestrial plants are the largest source of isoprene, with willow (Salix) making up one of the most active groups of isoprene producing trees. Bacteria act as a biological sink for isoprene and those bacteria associated with high isoprene-emitting trees may provide further insight into its biodegradation.ResultsA DNA-SIP experiment incubating willow (Salix fragilis) leaves with13C-labelled isoprene revealed an abundance ofComamonadaceae, Methylobacterium, MycobacteriumandPolaromonasin the isoprene degrading community when analysed by 16S rRNA gene amplicon sequencing. Metagenomic analysis of13C-enriched samples confirmed the abundance ofComamonadaceae, Acidovorax, Polaromonas, VariovoraxandRamlibacter. MycobacteriumandMethylobacteriumwere also identified after metagenomic analysis and aMycobacteriummetagenome-assembled genome (MAG) was recovered. This contained two complete isoprene degradation metabolic gene clusters, along with a propane monooxygenase gene cluster. Analysis of the abundance of the alpha subunit of the isoprene monooxygenase,isoA,in unenriched DNA samples revealed that isoprene degraders associated with willow leaves are abundant, making up nearly 0.2% of the natural bacterial community.ConclusionsAnalysis of the isoprene degrading community associated with willow leaves using DNA-SIP and focused metagenomics techniques enabled recovery of the genome of an active isoprene-degradingMycobacteriumspecies and provided valuable insight into bacteria involved in degradation of isoprene on the leaves of a key species of isoprene-emitting tree in the northern hemisphere.
Welfare receipt and the risk of vitamin D deficiency in Japanese patients on maintenance hemodialysis: a cross-sectional, retrospective study
Authors: Yoshida Keisuke , Yonaha Tomoki , Yamanouchi Masayuki , Sumi Hirofumi , Taki Yasuhiro , Otobe Yuhei , Miyashita Minoru , Hachisuka Rina , Han Wei , Shibagaki Yugo , Tominaga Naoto 
Published: August 2021

Abstract
Background
Vitamin D deficiency is often observed in patients undergoing maintenance hemodialysis and is associated with significantly increased risk of overall mortality. Despite reports of poor nutrition/intake, vitamin D status among patients on maintenance hemodialysis receiving welfare remains unknown. This study investigated the vitamin D status in welfare recipients undergoing maintenance hemodialysis.

Methods
This cross-sectional study investigated vitamin D status among 106 outpatients undergoing maintenance hemodialysis at two medical facilities in Japan. Patients were divided into welfare and non-welfare groups based on their status as of September 2018. Patients were divided into two categories: serum vitamin D deficiency, defined as serum 25(OH)D concentrations < 12 ng/mL, or non-deficiency. Vitamin D deficiency was used as a dependent variable, while welfare receipt was used as the main predictor variable.

Results
Mean [± standard deviation] patient age, median [interquartile range] body mass index, and hemodialysis duration were 66.9 [± 10.8] years, 21.5 [19.6, 24.3] kg/m2, and 7.9 [2.9, 12.3] years, respectively. Among 106 patients, 45 were women (42.5%) and 16 (15.1%) were receiving welfare. The welfare group had a higher diabetes prevalence (P = 0.003) and significantly lower median serum 25-hydroxyvitamin D concentrations (11.5 [8.7, 14.0] vs. 14.8 [11.2, 19.9] ng/mL, P = 0.005). Multiple logistic regression analysis revealed that welfare receipt was a significant risk factor for vitamin D deficiency (odds ratio [95% confidence interval], 4.41 [1.08, 18.07]).

Conclusions
Welfare recipients undergoing maintenance hemodialysis are at significantly increased risks of vitamin D deficiency compared with patients not receiving welfare.
A focused simulation-based optimization of print time and material usage with respect to orientation, layer height and support settings for multi-pathological anatomical models in inverted vat photopolymerization 3D printing
Authors: Ravi Prashanth , Chen Victoria C. P. 
Published: August 2021

Abstract
Background
3D printing of anatomical models requires multi-factorial decision making for optimal model manufacturing. Due to the complex nature of the printing process, there are frequently multiple potentialities based on the desired end goal. The task of identifying the most optimal combination of print control variables is inherently subjective and rests on sound operator intuition. This study investigates the effect of orientation, layer and support settings on print time and material usage. This study also presents a quantitative optimization framework to jointly optimize print time and material usage as a function of those settings for multi-pathological anatomical models.

Methods
Seven anatomical models representing different anatomical regions (cardiovascular, abdominal, neurological and maxillofacial) were selected for this study. A reference cube was also included in the simulations. Using PreForm print preparation software the print time and material usage was simulated for each model across 4 orientations, 2 layer heights, 2 support densities and 2 support tip sizes. A 90–10 weighted optimization was performed to identify the 5 most optimal treatment combinations that resulted in the lowest print time (90% weight) and material usage (10% weight) for each model.

Results
The 0.1 mm layer height was uniformly the most optimal setting across all models. Layer height had the largest effect on print time. Orientation had a complex effect on both print time and material usage in certain models. The support density and the support tip size settings were found to have a relatively minor effect on both print time and material usage. Hollow models had a larger support volume fraction compared to solid models.

Conclusions
The quantitative optimization framework identified the 5 most optimal treatment combinations for each model using a 90–10 weighting for print time and material usage. The presented optimization framework could be adapted based on the individual circumstance of each 3D printing lab and/or to potentially incorporate additional response variables of interest.
The CircumVent Project: a CPAP/O2 helmet solution for non-invasive ventilation using an implementation research framework
Authors: Ahonkhai Aimalohi A. , Musa Adesola Z. , Fenton André A. , Aliyu Muktar H. , Ofotokun Igho , Hornstein Alex , Musa Baba M. , Nwosu Nnamdi , Ulasi Ifeoma , Ajayi Samuel , Falade Catherine , Dada Adedamola , Abdu Aliyu , Sunday Mogaji , Odewabi Adenike , Rotimi Muyiwa K. , Ogueh Onome , Steinbach Alan , Ogedegbe Gbenga , Salako Babatunde L. , Ezechi Oliver C. 
Published: August 2021

Abstract
Background
Acute respiratory failure, a major cause of death in COVID-19, is managed with high-flow oxygen therapy via invasive mechanical ventilation. In resource-limited settings like Nigeria, the shortage of ventilators and oxygen supply makes this option challenging. Evidence-based non-invasive alternatives to mechanical ventilation such as the use of continuous positive airway pressure (CPAP) devices exist, but there have been concerns that non-invasive ventilation may expose healthcare workers to infection from aerosolized dispersion of SARS-CoV-2. We propose to evaluate the feasibility, adaptability and acceptability of a CPAP/O2 helmet solution for non-invasive ventilation among patients with COVID-19 and health workers in eight COVID-19 treatment and isolation centers in Nigeria.

Methods
The study will occur in 4 stages: (1) convene a Steering Committee of key stakeholders and recruit implementation sites; (2) use the integrated Promoting Action on Research Implementation in Health Services (i-PARiHS) framework to guide a needs assessment of treatment centers’ capacity to use high-flow oxygen therapy to treat COVID-19 patients and utilize the findings to develop an implementation strategy for the use of a CPAP/O2 helmet solution; (3) build infrastructure to support training and data monitoring processes and to develop implementation protocols to evaluate the adaptability of the strategy for the use of the CPAP/O2 helmet; and (4) train health workers, distribute a CPAP/O2 helmet solution for non-invasive ventilation, pilot test the implementation strategy, and assess feasibility of its use and acceptability that includes monitoring altered risk of SARS-CoV-2 infection among healthcare workers.

Discussion
The CPAP/O2 helmet solution for non-invasive ventilation in Nigeria can serve as a scalable model for resource-poor countries, and beyond the COVID-19 pandemic, has the potential to be deployed for the treatment of pneumonia and other respiratory diseases.

Trial registration
NCT04929691. Registered June 18, 2021—retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04929691