bluuebunny/crossref_metadata_2025_split huggingface dataset:
iOCT in der klinischen Anwendung
Authors: Friedrich Julia Sabina , Bleidißel Nathalie , Nasseri Ali , Feucht Nikolaus , Klaas Julian , Lohmann Chris Patrick , Maier Mathias 
Published: November 2021

Zusammenfassung
Hintergrund
Die Beurteilung der intraoperativen Veränderung der Netzhautmorphologie, insbesondere des vitreoretinalen Überganges, ist mithilfe der intraoperativen optischen Kohärenztomografie (iOCT) möglich geworden.

Ziel der Arbeit
Um die Bedeutung der intraoperativen Morphologie beim durchgreifenden Makulaforamen (MF) für das postoperative funktionelle Ergebnis zu evaluieren, wurde eine retrospektive, klinische Beobachtungsstudie durchgeführt.

Material und Methoden
Die Netzhautmorphologie wurde in 32 Augen von 32 konsekutiven Patienten mit durchgreifendem Makulaforamen mittels iOCT zu verschiedenen Zeitpunkten während der Operation beobachtet. Die Veränderungen wurden anschließend mit dem postoperativen funktionellen Ergebnis korreliert.

Ergebnisse
Nach Induktion der hinteren Glaskörperabhebung (HGA) reduzierte sich der Makulaforamen-Index (MHI) um −0,05 (p = 0,01), die basale Foramenbreite (FB) stieg um +99,4 μm (SD = 197,8 μm; p = 0,04). Die Verschlussrate betrug 100 % zum Zeitpunkt der ersten postoperativen Vorstellung nach im Mittel 73 Tagen, der postoperative Visus verbesserte sich signifikant (p < 0,05).
Es zeigte sich eine signifikant positive Korrelation von intraoperativer Morphologie und postoperativem Ergebnis zwischen einem niedrigen MHI und einem besseren postoperativen Visus (SKK = 0,50; p = 0,02), zwischen einer großen FB und einem besseren postoperativen Visus (SKK = 0,43; p = 0,05) sowie zwischen einer breiten Apertur nach HGA und einem größeren Visusanstieg postoperativ (SKK = 0,44; p = 0,03).

Diskussion
Wir konnten eine Abflachung sowie eine Verbreiterung des MF durch Lösen der vitreoretinalen Zugkräfte beobachten. Aufgrund des Zusammenhangs zwischen einer großen intraoperativen FB mit einem besseren postoperativen Visus scheint die intraoperative Relaxierung der Netzhaut bedeutsam.
Stress anisotropy in natural debris flows during impacting a monitoring structure
Authors: Nagl Georg , Hübl Johannes , Kaitna Roland 
Published: November 2021

AbstractThe frictional resistance of rock and debris is supposed to induce stress anisotropy in the unsteady, non-uniform flow of gravitational mass flows, including debris flows. Though widely used in analytical models and numerical simulation tools, concurrent measurements of stresses in different directions are not yet available for natural flow events. The present study aims to investigate the relation of longitudinal and bed-normal stress exerted by two natural debris flows impacting a monitoring barrier in the Gadria creek, Italy. For that, a force plate in front of a barrier was used to continuously record forces normal to the channel bed, whereas load cells mounted on the vertical wall of the barrier recorded forces in flow direction. We observed an anisotropic stress state during most of the flow events, with stress ratios ranging between 0.1 and 3.5. Video recordings reveal complex deposition and re-mobilization patterns in front of the barrier during surges and highlight the unsteady nature of debris flows. These first-time in-situ measurements confirm the assumption of stress anisotropy in natural debris flows for gravitational mass flows, and provide data for model testing.
The role of lymphangiogenesis in cardiovascular diseases and heart transplantation
Authors: Ji Rui-Cheng 
Published: November 2021

AbstractCardiac lymphangiogenesis plays an important physiological role in the regulation of interstitial fluid homeostasis, inflammatory, and immune responses. Impaired or excessive cardiac lymphatic remodeling and insufficient lymph drainage have been implicated in several cardiovascular diseases including atherosclerosis and myocardial infarction (MI). Although the molecular mechanisms underlying the regulation of functional lymphatics are not fully understood, the interplay between lymphangiogenesis and immune regulation has recently been explored in relation to the initiation and development of these diseases. In this field, experimental therapeutic strategies targeting lymphangiogenesis have shown promise by reducing myocardial inflammation, edema and fibrosis, and improving cardiac function. On the other hand, however, whether lymphangiogenesis is beneficial or detrimental to cardiac transplant survival remains controversial. In the light of recent evidence, cardiac lymphangiogenesis, a thriving and challenging field has been summarized and discussed, which may improve our knowledge in the pathogenesis of cardiovascular diseases and transplant biology.
Interaction of Psychopathic Traits Dimensions in the Prediction of Psychological and Physical Child-to-Parent Violence in Adolescents
Authors: Del Hoyo-Bilbao Joana , Orue Izaskun , Calvete Esther 
Published: November 2021

AbstractThis study examined the longitudinal relationships between three psychopathic trait dimensions (callous-unemotional, CU; grandiose-manipulative, GM; and impulsive-irresponsible, II) and their interaction in the prediction of psychological and physical child-to-parent violence (CPV). Furthermore, the study examined whether the predictive relationships were different for boys and girls. A total of 765 adolescents (463 girls), with a mean age of 15.28 years (SD = 1.04), completed measures of the psychopathic trait dimensions (CU, GM, and II) and psychological and physical CPV at the beginning of the study and six months later. At the cross-sectional level, all the psychopathic trait dimensions were related to psychological and physical CPV, although the effect sizes were small. At the longitudinal level, II predicted increased psychological CPV. A significant three-way interaction between the three psychopathic trait dimensions (CU, GM, and II) indicated that the longitudinal association between II and physical CPV was higher for adolescents with high CU and low GM. However, the predictive model did not differ for boys and girls.
What Drives Water Utility Selection of Pricing Methods? Evidence from California
Authors: Allaire M. , Dinar A. 
Published: November 2021

AbstractWater pricing is a demand management strategy to address the looming challenge of greater water scarcity in arid regions. Much of the literature on residential water rates focuses on evaluating the impact of pricing on household conservation. A separate, but rarely addressed question is what motivates a water utility to select a particular rate structure and the timing of doing so. We assess utilities’ decisions to adopt pro-conservation rate structures, such as increasing block rates and water budget rates. We develop a conceptual model of utility decision-making regarding the transition to pro-conservation rates and apply it to California.We examine the relationship between rate adoption and characteristics of utilities and customers using logistic regression and a balanced panel dataset of 323 California water systems from 2006-2015. We find a notable shift towards pro-conservation rates, which 71% of California utilities had by 2015, compared to 44% in 2006. Capacity factors associated with adoption include size of service population and customer income level, while motivating factors include peer adoption, greater customer engagement, and special district governance. Overall, this study provides insight into barriers to pro-conservation pricing, which can inform policies to enable transitions and advance conservation goals.
Die Rolle des Selbstkonzepts im Mathematikstudium – Wie fit fühlen sich Studierende in Mathematik?
Authors: Rach Stefanie , Ufer Stefan , Kosiol Timo 
Published: November 2021

ZusammenfassungDas mathematische Selbstkonzept als Einschätzung der eigenen Fähigkeiten ist relevant für erfolgreiche Lernprozesse. Am Übergang in ein Mathematikstudium ändert sich die Domäne, sodass eine Schul- von einer universitären Mathematik unterschieden werden kann. In diesem Beitrag schlagen wir ein dreidimensionales Modell vor, das ein allgemeines, ein schulisches und ein universitäres mathematisches Selbstkonzept ausdifferenziert. Anhand einer Studie mit 202 Mathematikstudierenden (Fach bzw. Lehramt) geben wir Hinweise für die Güte der neu entwickelten Fragebogenskalen. Schon zu Studienbeginn kann ein Selbstkonzept in Bezug auf die Schulmathematik von einem Selbstkonzept in Bezug auf die universitäre Mathematik unterschieden werden. Die Entwicklung des mathematischen Selbstkonzepts in den ersten Wochen kann durch die differenzierten Facetten präziser beschrieben werden: Während die schulische Facette im Mittel stabil bleibt, verringert sich das universitäre Selbstkonzept, insbesondere bei den Lehramtsstudierenden. Das universitäre und das allgemeine mathematische Selbstkonzept prädizieren die Studienzufriedenheit positiv. Implikationen aus der differenzierten Messung werden diskutiert.
Sn-Aided Joining of Cast Aluminum and Steel Through a Compound Casting Process
Authors: Bakke Aina Opsal , Nordmark Arne , Arnberg Lars , Li Yanjun 
Published: November 2021

Abstract
Obtaining a strong bond between aluminum and steel is challenging due to poor wettability between aluminum melt and steel and brittle intermetallic phases forming in the interface. In this research, a novel coating method, namely hot dipping of Sn, has been developed to treat the steel insert surfaces. Results show that without preheating the mold or Sn-coated insert, a thin, crack-free, and continuous metallurgical bonding layer was achieved in the A356 aluminum/steel compound castings. Intermetallic structures forming in the interface have been characterized in detail. The Sn-coating layer completely melted and mixed with the liquid aluminum during the casting process. The reaction layer at the aluminum/steel interface is composed of ternary Al–Fe–Si particles and a thin layer of binary Al5Fe2 phase with thickness less than 1 µm. A small fraction of dispersed Sn-rich particles was observed distributing in the reaction layer and adjacent to eutectic Si particles in the A356 alloy. A sessile drop wetting test showed that Sn-coated steel substrates can be well wetted by aluminum melt. The improved wettability between A356 alloy melt and steel was attributed to the penetration and breaking of the aluminum oxide layer at the surface of the aluminum droplets by liquid Sn.

Graphic Abstract
Evaluation of an electronic psycho-oncological adaptive screening program (EPAS) with immediate patient feedback: findings from a German cluster intervention study
Authors: Esser Peter , Sautier Leon , Sarkar Susanne , Schilling Georgia , Bokemeyer Carsten , Koch Uwe , Rose Matthias , Friedrich Michael , Nolte Sandra , Walter Otto , Mehnert-Theuerkauf Anja 
Published: November 2021

Abstract
Purpose
Distress screening has become mandatory and essential in comprehensive cancer care. We evaluated an electronic psycho-oncological adaptive screening (EPAS) which assesses objective indicators of care needs and subjectively perceived care needs and subsequently provides patient feedback with individualized recommendations about psychosocial care services.

Methods
Patients were assessed within clusters, i.e., different oncological facilities of the competence network of the University Cancer Center Hamburg (UCCH). Patients in the intervention arm underwent the screening, controls received standard care. Patients were assessed at baseline (t0), 3-month (t1), and 6-month (t2) follow-up. Outcomes included information level and use of/access to nine psychosocial services at UCCH, well-being (GAD-7, PHQ-9, SF-8), and treatment satisfaction (SCCC). Conditional linear and logistic regressions were used to identify screening effects at t1 and t2.

Results
Of 1320 eligible patients across 11 clusters, 660 were included (50%). The average age was 60 years; 46% were female. The intervention was associated with increased information level for all psychosocial services at t1 and t2 (all p < .001), increased use in some of these services at t1 and t2, respectively (p ≤ .02), and better evaluation of access (e.g., more recommendations for services provided by physicians, p < .01). At t2, the intervention was associated with a lower level of satisfaction with disease-related information (p = .02).

Conclusions
EPAS may improve information about psychosocial services as well as utilization of and access to these services. The effect on information level seems not to be generalizable to other aspects of oncological care. Future studies should incorporate novel technologies and condense the procedure to its core factors.
Implications for Cancer Survivors: The screening may help to enhance self-management competencies among cancer survivors.

Trial registration
The trial was retrospectively registered (2/2021) at ClinicalTrials.gov (number: NCT04749056).
Research Ethical Norms, Guidance and the Internet
Authors: Salwén Håkan 
Published: November 2021

AbstractThe internet, either as a tool or as an area of research, adds moral worries to an already complicated research ethical backdrop. Agencies, professional associations and philosophers have formulated research ethical norms designed to help scientists to arrive at responsible solutions to the problems. Yet, many criticize this reliance on norms. Somewhat more precisely, many claim that research ethical norms do not offer guidance. In the literature at least three arguments to that effect can be found. First, the research ethical norms fail to guide since they are inconsistent. Second, they fail to guide since they are too opaque. Third, they fail to guide since they cannot handle the moral complexity of issues scientists doing e-research face. In this paper I argue that these arguments are weak. The arguments are, in their original formulations, rather unclear. I try to improve the situation by spelling out the arguments with reference to a certain set of research ethical norms, to a certain account of action-guidance and with reference to certain important distinctions. It then turns out that the arguments’ premises are either untenable or suffers from lack of relevance. The arguments do not force us to conclude that research ethical norms fail to guide.
Challenges of applying monophyly in the phylogenetic shallows: taxonomic reappraisal of the Dactylorhiza maculata group
Authors: Bateman Richard M. 
Published: November 2021

SummaryThe first study of the taxonomically critical European orchid genus Dactylorhiza to use next-generation DNA sequencing generated the statistically best-supported reconstruction of its phylogeny to date. However, the two competing topologies obtained within the monophyletic Section Maculatae differed radically in the placement of the D. maculata s.s.–D. foliosa clade. Both topologies showed D. foliosa to be nested deeply within D. maculata s.s., and suggested that D. saccifera s.l. is paraphyletic, D. saccifera s.s. from south-eastern Europe and Asia Minor diverging before D. gervasiana from south-central Europe (a taxon typically viewed as a subspecies of D. saccifera or, more often, ignored completely). The poorly-sampled but character-rich morphometric comparison presented here suggests that D. saccifera s.s. and D. gervasiana cannot be distinguished with confidence using morphological characters and that, if D. gervasiana is accepted as a species, it is effectively cryptic. The diploid D. foliosa is accepted as an island endemic species, despite rendering paraphyletic the autotetraploid D. maculata s.s.; all other named taxa within the D. maculata s.s. clade are considered infraspecific. Dactylorhiza fuchsii is indisputably a bona fide species rather than a subspecies but it does not merit becoming the basis of a taxonomic section separate from D. maculata s.s. The strongly contrasting degrees of molecular vs morphological disparity reported here are representative of a more general trend evident in groups that have experienced comparatively recent speciation, as is the need to recognise occasional paraphyletic species when circumscribing species by integrating genotypic and phenotypic data categories. Explicit taxonomic criteria combined with a comparative, monographic approach are needed to achieve consistency of ranking. Disproving hypotheses of species status is judged a criminally underrated activity, actually being as important to outcomes as much-vaunted species "discovery".
Drug discovery in leishmaniasis using protein lipidation as a target
Authors: Brannigan James A. , Wilkinson Anthony J. 
Published: November 2021

AbstractThe leishmaniases are infectious diseases caused by a number of species of obligate intracellular protozoa of the genus Leishmania with disease manifesting as cutaneous, mucocutaneous and visceral forms. Despite being endemic in more than 80 countries and its being the cause of high morbidity and mortality, leishmaniasis remains a neglected tropical disease. Chemotherapy is the frontline treatment, but drugs in current use suffer from toxic side effects, difficulties in administration and extended treatment times — moreover, resistance is emerging. New anti-leishmanial drugs are a recognised international priority. Here, we review investigations into N-myristoyltransferase (NMT) as a potential drug target. NMT catalyses the co-translational transfer of a C14 fatty acid from myristoyl-CoA onto the N-terminal glycine residue of a significant subset of proteins in eukaryotic cells. This covalent modification influences the stability and interactions of substrate proteins with lipids and partner proteins. Structure-guided development of new lead compounds emerging from high-throughput screening campaigns targeting Leishmania donovani NMT has led to the discovery of potent inhibitors which have been used to gain insights into the role of protein myristoylation in these parasites and to validate NMT as a drug target.
Caring from behind the face mask in healthcare: Learning from the dramatic arts
Authors: Murphy Paul , Lewis Dearbhail , Gormley Gerard J. 
Published: November 2021

The COVID-19 pandemic has made its impact across the globe with great voracity. New routines have displaced older more established ones with ruthless efficiency—no more so than in healthcare. In meeting these challenges, many healthcare workers have had to prepare for and enact many new ways of working. Regardless of their speciality or stage of training, health professions educators (HPEs) have helped train our healthcare workforce in developing new skills with great tempo. Throughout all of these efforts one constant has guided our endeavours—the humane connection with those that provide and those that seek healthcare.
However, with COVID-19 we have had to distance ourselves from our patients, and colleagues, and clad ourselves in various items of personal protection equipment (PPE). The protective barrier also acts as a barrier to personal interaction and therefore presents challenges in how we connect with each other on a humane level. Few disciplines have engaged with the complexities of verbal and gestural communication as thoroughly and consistently as the dramatic arts. Actors in Ancient Greece would perform wearing masks and used oratory as well as gestural communication to enrapture the audience.
Drawing upon the dramatic arts, we aim to explore the relationship between face and mask and thereby provide reflective insights for HPEs to help guide healthcare workers in their communication from behind the face mask.
Textverstehen als argumentativer Diskurs
Authors: Descher Stefan , Petraschka Thomas 
Published: November 2021

ZusammenfassungIn diesem Beitrag erläutern wir, wieso es aktuell keine »Krise des Textverstehens« gibt, die eine erneute Reflexion hermeneutischer Grundlagen erfordern würde. Wir zeigen, dass derartige Diagnosen entweder auf gesellschaftliche Probleme zurückgehen, die den Grundlagen hermeneutischer Theoriebildung äußerlich sind, oder auf irrige Annahmen über einen theoretischen und methodischen Pluralismus innerhalb der Literaturwissenschaften. Statt der Entwicklung einer »neuen Hermeneutik« ist innerhalb der Philologie vielmehr eine verstärkte Rückbesinnung auf den common ground aller Spielarten wissenschaftlicher Textinterpretation angebracht: den auf universalen Rationalitätsprinzipien beruhenden argumentativen Diskurs. Im zweiten Teil des Beitrags führen wir dann anhand von drei exemplarischen Maximen aus, wie sich dieses allgemeine Plädoyer in die Praxis philologischer Hermeneutik integrieren lässt.
A ‘Network of Understanding and Compassion’: A Qualitative Study of Survivor Perspectives on Unmet Needs After Traumatic Brain Injury (TBI) in Regional Communities
Authors: Hennessy Maria Jeannette , Sullivan Karen A. 
Published: November 2021

AbstractObjective:This qualitative study aimed to identify the service and support needs of people with a recent history of traumatic brain injury (TBI) living in the community.Methods:A postal survey was sent to 662 people 6–18 months after hospital admission for a mild-to-severe TBI. The survey included an open-ended item (‘wish-basket’) for collecting ideas about important unmet needs.Results:Responses from 53 individuals were coded and processed using thematic analysis. Five themes (n = 39) were identified, three of which were related to personal needs. These personal wishes were about being symptom-free, independent and emotionally supported by, and connected to, loved ones. The remaining themes were about the wished-for changes to the health system and society, such as wishing for health care continuity (as opposed to being abandoned), and for greater understanding and support by society.Conclusions:There is scope to improve the services and support for people living with TBI in the community. This includes reconsidering the way that discharge occurs, addressing the personal needs that remain when living in the community and promoting greater social awareness of TBI to counteract disadvantage.
Radical Islam in the Western Academy
Authors: Kazmi Zaheer 
Published: November 2021

AbstractScholarly interest in radical Islam is long-standing and crosses multiple disciplines. Yet, while the labelling of Islam and Muslim actors as ‘radical’ is extensive, this has not been interrogated as a particular scholarly practice. And while studies of non-Western radicalism have grown in recent years, cross-cultural analysis of radicalism as a particular concept in political thought has been neglected. This article aims to begin to address this question, with reference to radical Islam. By treating radicalism as a meta-concept, it identifies radical Islam as a malleable and composite category that is constituted by, and made legible through, conceptual properties associated with four discourses in the study of radicalism with origins in the Western academy: Euro-radicalism, identified with the European left and critical theory; fundamentalism; radicalisation; and liberalism. I argue that radical Islam is under-theorised and over-determined as a scholarly category. This can be explained by how concepts originating in the Western academy to address Western contexts and phenomena function as master frameworks, narratives, or pivots against or around which radical Islam is defined. This is the case even when Eurocentrism is contested by critical theorists who tend to reproduce it because they do not abandon Western conceptions of radicalism but rather draw on them. Academic accounts of radical Islam also authenticate Islam by advancing selective, strategic or apologetic descriptions of what constitutes radicalism. In these ways, critical scholarship, including within IR, can also be insufficiently attentive to marginal and heterodox voices that fall outside hegemonic conceptions of Islamic normativity.