bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hiệu quả điều trị nhịp nhanh kịch phát trên thất có giảm chức năng tâm thu thất trái ở trẻ em bằng năng lượng sóng có tần số radio tại Bệnh viện Nhi Trung ương
Authors: Tien Bang Quach , Huu Hoa Pham 
Published: May 2021

Mục tiêu: Nhận xét kết quả điều trị ban đầu nhịp nhanh kịch phát trên thất có giảm chức năng tâm thu thất trái ở trẻ em bằng năng lượng sóng có tần số radio tại Bệnh viện Nhi Trung ương.
Đối tượng và phương pháp nghiên cứu: 35 bệnh nhân dưới 18 tuổi được chẩn đoán là nhịp nhanh kịch phát trên thất (NNKPTT) hoặc Wolf-Parkinson-White có giảm chức năng tâm thu thất trái được điều trị bằng năng lượng sóng có tần số radio (NLSCTSR) tại Trung tâm Tim mạch trẻ em Bệnh viện Nhi TW từ tháng 1/2017 - 6/2020.
Kết quả: Độ tuổi trung bình của đối tượng nghiên cứu là 2,61 tuổi (1 tháng – 13,3 tuổi), cân nặng trung bình 12,4kg (3,7 – 48kg), tỉ lệ nam/nữ 1,05/1. Thăm dò điện sinh lý xác định 25 bệnh nhi bị tim nhanh vòng vào lại nhĩ thất (TNVVLNT), 9 bệnh nhân tim nhanh nhĩ (TNN), 1 bệnh nhân tim nhanh vòng vào lại nút nhĩ thất (TNVVLNNT). Tỉ lệ thành công của thủ thuật triệt đốt bằng NLSCTSR lần lượt là 92% đối với TNVVLNT, 55,6% đối với TNN và không thành công đối với 1 bệnh nhân TNVVLNNT (p=0,012). Không có biến chứng liên quan đến thủ thuật. Tỉ lệ tái phát là 3,57% ngay trước thời điểm ra viện. Giá trị đường kính thất trái tâm trương và phân suất tống máu thất trái trung bình trước can thiệp bằng NLSCTSR lần lượt là 3,5 ± 3,4 SD và 41,2 ± 11,6%. Ba tháng sau can thiệp (n=22), giá trị phân suất tống máu thất trái trung bình là 61,2 ± 7,7% và 12 tháng sau (n=13) giá trị đường kính thất trái cuối tâm trương của nhóm can thiệp thành công là 1,1 ± 1,2 SD, còn nhóm can thiệp không thành công là 4,2 ± 2,7 SD.
Kết luận: Điều trị NNKPTT bằng NLSCTSR là phương pháp điều trị hiệu quả và an toàn cho trẻ em. Có mối liên quan chặt chẽ giữa kết quả triệt đốt tim nhanh với mức độ giãn và chức năng tâm thu thất trái.
Gestión del conocimiento y del aprendizaje: paradigma de la innovación universitaria
Authors: Peluffo Marta Beatriz 
Published: May 2021

El presente artículo aborda las diferentes problemáticas que se generan en la transición de una institución universitaria tradicional a una institución universitaria innovadora y articulada con el contexto a través de la incorporación de las herramientas de la gestión del conocimiento y del aprendizaje. En primer lugar, se analiza la relación entre conocimiento y desarrollo como variables interconectadas al desarrollo humano y del territorio donde conviven
Methotrexate in dermatology: from theory to practice
Authors: Галлямова Ю.А. , Асоскова А.В. 
Published: May 2021

Метотрексат зарекомендовал себя как высокоэффективное средство для лечения псориаза с 1953 г. Эффективность метотрексата обусловлена его цитотоксическим и противовоспалительным действием. Согласно проекту клинических рекомендаций Российского общества дерматовенерологов и косметологов применение метотрексата обосновано при многих заболеваниях кожи. Длительная история и накопленный практический опыт применения не вызывают сомнения в эффективности метотрексата, обусловленной его уникальными фармакологическими свойствами, а именно противовоспалительным, иммуномодулирующим и кумулятивным эффектами, которые позволяют препарату занимать лидирующие позиции в терапии многих кожных заболеваний. В статье подробно раскрыты метаболизм метотрексата и его фармакодинамика. Согласно обзору современных данных мировой литературы авторы представили рекомендации по лечению метотрексатом, применению его у детей, мониторингу во время лечения, а также обратили внимание на показания при особых ситуациях (инфекции, прививки, контрацепция и т. д.).
Methotrexate has established itself as a highly effective treatment for psoriasis since 1953. The effectiveness of methotrexate is due to its cytotoxic and anti-inflammatory effects. According to the draft clinical guidelines of the Russian Society of Dermatovenereologists and Cosmetologists, the use of methotrexate is justified in many skin diseases. A long history and accumulated practical experience of application do not raise doubts about the effectiveness of methotrexate due to its unique pharmacological properties, namely, anti-inflammatory, immunomodulatory and cumulative effects, which allow the drug to occupy a leading position in the treatment of many skin diseases. The article describes in detail the metabolism of methotrexate and its pharmacodynamics. According to a review of modern data from the world literature, the authors presented recommendations for treatment with methotrexate, its use in children, monitoring during treatment, and also drew attention to the indications in special situations (infections, vaccinations, contraception, etc.).
Neuromyelitis optica spectrum disorder: importance and difficulties of differential diagnosis with multiple sclerosis
Authors: Давыдовская М. В. 
Published: May 2021

Заболевания спектра оптиконевромиелита представляют собой небольшую группу редко встречающихся, но очень тяжелых иммуноопосредованных неврологических нарушений. Об отличиях заболевания от рассеянного склероза, особенностях диагностики и терапии, о последствиях неверного диагноза и поддержке пациентов рассказала заместитель главного внештатного специалиста-невролога департамента здравоохранения г. Москвы (ДЗМ), доктор медицинских наук Мария Вафаевна Давыдовская.
Neuromyelitis optica spectrum disorder is a group of rare and severe immune-mediated neurological conditions. We have discussed with Maria Davydovskaya, the Deputy Chief External Experts in Neurology, the key differences of this disease from multiple sclerosis, special aspects of diagnostics and therapy, the consequences of misdiagnose, and patients support.
Editorial
Authors: Arbulú Mario 
Published: May 2021

La unidad de Publicaciones, la Dirección Nacional de Investigación y la Escuela de Ingeniería de la Corporación Unificada Nacional de Educación Superior (cun), con la intención de garantizar la transferencia tecnológica y visibilizar los trabajos de nuestros estudiantes y pares académicos de otras instituciones, tienen el gusto de presentar en esta edición de la revista #ashtag un conjunto de artículos relativos a electrónica de potencia, inteligencia artificial y robótica móvil. La enseñanza de sistemas de potencia con pwm se facilita con el abordaje de una herramienta didác[1]tica que induce a los estudiantes a explorar el potencial de la generación de señales pwm y su utilidad en aplicaciones prácticas en la industria. Dada la importancia de este asunto, el primer artículo versa precisamente sobre la conexión de la electrónica digital con el software, para generar distintos ciclos de trabajo pwm. La robótica móvil inteligente se aborda en esta edición a través del segundo artículo, que describe la solución de un circuito en forma de laberinto a través de algoritmos de navegación clásica y reacción con el entorno, aplicados en un robot móvil diseñado según las especificaciones de un reto de navegación inteligente en entornos complejos. Los circuitos de potencia de los inversores, ampliamente usados en la actualidad en los sistemas de energías renovables para transformar corriente directa en corriente alterna (ca), tienen lugar en esta edición a través del tercer artículo, que explica cómo mejorar la eficiencia de los inversores y llevarlos al punto de obtener el 96 % con carga resistiva y hasta un 90 % con carga reactiva. Por su parte, los robots móviles necesitan de un sistema de control para poder seguir sus referencias de movimiento en los entornos donde se desplazan. Las siguientes dos propuestas de esta edición involucran los algoritmos de control (local y global), el hardware seleccionado y su respectiva implementación en los robots que participaron en el Reto Indiana, organizado por nuestra institución, que incentiva la creatividad y el diseño aplicado de nuestros estudiantes. Los algoritmos genéticos aplicados para resolver problemas y adaptarse a entornos dinámicos con tribuyen a distintos casos prácticos. Se demostrará la filosofía y esencia de su funcionamiento en el sexto y último artículo, dedicado a la visualización de un mapa auto-organizado. Espero que estos importantes aportes a la transferencia de la ciencia y la tecnología entre nuestros estudiantes e investigadores, que con su esfuerzo conjunto determinarán el futuro del país, sean de su interés.
Analýza potřeb studentů odborného francouzského jazyka v přípravě na pracovní stáže ve Francii
Authors: Delalande Hana 
Published: May 2021

V příspěvku je představen kontext disertačního výzkumu, jehož cílem je zmapovat náplň pracovních stáží českých a slovenských studentů ve francouzských institucích veřejné správy, identifikovat komunikační situace, do kterých se studenti během stáží dostávají, a definovat úlohy, které musí řešit. Na základě rozhovorů se studenty francouzsko-českého studijního programu ESF MU Veřejná správa (Administration publique) bezprostředně po ukončení pracovní stáže byly v rámci pilotního výzkumu v roce 2018 identifikovány problematické situace a okruhy a analyzovány z hlediska potřeb chybějících v předcházející přípravě. V závěru příspěvku jsou prezentovány možnosti zefektivnění přípravy na stáže a další kroky disertačního výzkumu.
Eliminácia plagiátorstva z projektových prác študentov
Authors: Kaščáková Eva , Kožaríková Henrieta 
Published: May 2021

Projektové vyučovanie je veľmi populárne už niekoľko desaťročí a študenti sa počas štúdia pravidelne stretávajú s rôznymi projektovými úlohami. Napriek tomu, že v čase, keď začínajú vysokoškolské vzdelávanie majú s projektovou prácou bohaté skúsenosti, mnohým študentom často chýbajú základné akademické návyky a zručnosti, najmä vo vzťahu k akademickej nečestnosti a plagiátorstvu. Príspevok sa pokúša identifikovať typické porušovanie akademickej etiky v záverečných projektoch kurzov obchodnej angličtiny, ako napríklad neuvedenie autorstva prevzatej myšlienky, úmyselné a neúmyselné plagiátorstvo, nevhodné parafrázovanie, neakceptovateľné používanie citácií alebo iné nedostatky súvisiace s používaním zdrojov. Autorky sa v príspevku venujú príčinám takéhoto správania a riešeniam, ktoré presahujú využitie sofistikovaných testov originality. Okrem potreby náležitého vzdelávania v správnom citovaní, parafrázovaní a sumarizovaní, poukazujú aj na potrebu prehodnotenia relevantnosti úlohy, ktorá je nevyhnutná pre správne vypracovanie projektu. Dosiahne sa tak nielen originalita výsledkov, ale aj autentickosť práce a rozvoj relevantných zručností pre 21. storočie, ako je kritické myslenie, riešenie problémov, tvorivosť, spolupráca, informačná gramotnosť, produktivita a zodpovednosť. Nadobudnutie týchto zručností vedie k rozvoju schopnosti autonómneho celoživotného vzdelávania.
Education and Migration:
Authors: N. V. Varghese  
Published: May 2021

The Indian diaspora consists of low- and semi-skilled migrants mainly tothe Middle-East; migration of the highly-skilled to developed countries;and cross-border students who seek employment and remain in their hostcountries. India initially viewed the migration of the best educated fromits prestigious institutions as ‘brain drain’. However, with the reverse flowof these professionals, the diaspora came to be seen as ‘brain gain’. Thehighly-skilled Indian diaspora assumed positions of responsibility in thecorporate world, in academia (including Nobel laureates), and in the politicaland social spheres in some host countries, thereby enhancing India’simage abroad.
Key words: India, skilled migration, human aspirations, brain drain, braingain
Autonomous Sensory Meridian Response self-reporters showed higher scores for cognitive reappraisal as an emotion regulation strategy
Authors: Morales Ricardo , Ramírez-Benavides Daniela , Villena-Gonzalez Mario 
Published: May 2021

Background
Autonomous Sensory Meridian Response (ASMR) describes the experience of a pleasant tingling sensation along the back of the head, accompanied with a feeling of well-being and relaxation, in response to specific audio-visual stimuli, such as whispers, soft sounds, and personal attention. Previous works have assessed individual variations in personality traits associated with ASMR, but no research to date has explored differences in emotion regulation associated with ASMR. This omission occurred even when ASMR, a sensory-emotional experience, has been proposed to be located in a sound sensitivity spectrum as the opposite end of misophonia, a phenomenon associated with difficulties regulating emotions. The present work aimed to assess group differences between ASMR self-reporters and non-ASMR controls associated with emotion regulation strategies.

Methods
We used the validated Spanish version of the Emotion Regulation Questionnaire to assess individual differences in the use of cognitive reappraisal and expressive suppression.

Results
Our results showed that participants who experience ASMR had higher scores in the cognitive reappraisal subscale of the emotion regulation questionnaire than the non-ASMR group.

Conclusions
Individuals who experience ASMR reported higher use of cognitive reevaluation of emotionally arousing situations, suggesting more effectiveness in regulating emotions. Our finding further elucidates individual differences related to this experience, supporting that ASMR is a real psychophysiological phenomenon associated with other psychological constructs and has remarkable consequences in affective/emotional dimensions and general well-being.
Pattern of Psychoactive Substances Use among Long-Distance Truck Drivers in Nigeria
Authors: Dada Mobolaji Usman , Adeoti Adekunle Olatayo , Elebiyo Tobiloba , Kumolalo Banji Ferdinand ` , Ajiboye Adedotun Samuel 
Published: May 2021

Aims: This study was designed to examine the pattern of psychoactive drugs use among long-distance truck drivers in Ado-Ekiti, Ekiti state, Nigeria.
Study Design: This was a descriptive cross sectional study.
Place and Duration: The study was conducted at the converging motor park for truck drivers in Ado-Ekiti, south-west Nigeria between September and December 2019.
Methods: The pattern of psychoactive drugs use among 306 adult male truck drivers was determined using a semi-structured questionnaire in addition to a sociodemographic questionnaire. Data was analyzed and logistic regression was used to identify significant predictors of illicit drug use.
Results: Among the 306 study participants, 43.7% consumed alcohol. The major non-prescription drugs used by the truck drivers were cough syrups (67.0%); analgesics (49.3%); cannabis (39.9%); amphetamine/methamphetamine (33.0%) and tranquilizers (32.0%). Opioid analgesics like tramadol (35.1%) and morphine (22.3%) were the commonly used analgesics. The predictor of psychoactive drugs use among the long-distance truck drivers is the co-use of alcohol and tobacco (AOR (1.71) 95% CI (1.24–2.36%).
Conclusion: There is a high rate of psychoactive drugs use among truck drivers. There is an urgent need to educate the truck drivers on the adverse implications of illicit drug use and the need to abstain for better health promotion.
Application programming interface guided QA plan generation and analysis automation
Authors: Schmidt Matthew C. , Raman Caleb A. , Wu Yu , Yaqoub Mahmoud M. , Hao Yao , Mahon Rebecca Nichole , Riblett Matthew J. , Knutson Nels C. , Sajo Erno , Zygmanski Piotr , Jandel Marian , Reynoso Francisco J. , Sun Baozhou 
Published: May 2021

AbstractPurposeLinear accelerator quality assurance (QA) in radiation therapy is a time consuming but fundamental part of ensuring the performance characteristics of radiation delivering machines. The goal of this work is to develop an automated and standardized QA plan generation and analysis system in the Oncology Information System (OIS) to streamline the QA process.MethodsAutomating the QA process includes two software components: the AutoQA Builder to generate daily, monthly, quarterly, and miscellaneous periodic linear accelerator QA plans within the Treatment Planning System (TPS) and the AutoQA Analysis to analyze images collected on the Electronic Portal Imaging Device (EPID) allowing for a rapid analysis of the acquired QA images. To verify the results of the automated QA analysis, results were compared to the current standard for QA assessment for the jaw junction, light‐radiation coincidence, picket fence, and volumetric modulated arc therapy (VMAT) QA plans across three linacs and over a 6‐month period.ResultsThe AutoQA Builder application has been utilized clinically 322 times to create QA patients, construct phantom images, and deploy common periodic QA tests across multiple institutions, linear accelerators, and physicists. Comparing the AutoQA Analysis results with our current institutional QA standard the mean difference of the ratio of intensity values within the field‐matched junction and ball‐bearing position detection was 0.012 ± 0.053 (P = 0.159) and is 0.011 ± 0.224 mm (P = 0.355), respectively. Analysis of VMAT QA plans resulted in a maximum percentage difference of 0.3%.ConclusionThe automated creation and analysis of quality assurance plans using multiple APIs can be of immediate benefit to linear accelerator quality assurance efficiency and standardization. QA plan creation can be done without following tedious procedures through API assistance, and analysis can be performed inside of the clinical OIS in an automated fashion.
A Charge‐Based Mechanistic Study into the Effect of Collector Temperature on Melt Electrohydrodynamic Printing Outcomes
Authors: Cao Kai , Zhang Fucheng , Zaeri Ahmadreza , Zgeib Ralf , Chang Robert C. 
Published: May 2021

AbstractMelt electrowriting (MEW) is an emerging additive process for high‐fidelity, microscale fibrous scaffold fabrication. However, achieving precise multilayered MEW‐enabled scaffolds is limited by the entrapped residual charges owing to charge‐based mechanisms. Specifically, the semi‐conductive nature of processed materials causes retainment of net positive charges and jet–fiber repulsion, while exposure to the electric field yields charge polarization with resultant jet–fiber attraction. These competing effects work in tandem to determine the distinctive features of jet–fiber interaction. To deconstruct various charge‐related phenomena, the collector temperature is manipulated as a key process variable to investigate its effect on printing outcomes in two printing modes. Moreover, energy analysis is introduced to explain how collector temperature affects the polarization extent, along with the jet–fiber interaction and printing outcomes. In single fiber printing mode, sets of two parallel fibers with variable set interfiber distances (sSf) are printed at different collector temperatures. At a low sSf threshold, significant fiber attraction is observed, but no significant difference is observed among the cases at different collector temperatures. In scaffold printing mode, 200‐layer scaffolds are printed at different collector temperatures, and the wall morphologies are found to vary with location, layer number, and collector temperature.
Quantitative trait locus mapping reveals an independent genetic basis for joint divergence in leaf function, life‐history, and floral traits between scarlet monkeyflower (Mimulus cardinalis) populations
Authors: Nelson Thomas C. , Muir Christopher D. , Stathos Angela M. , Vanderpool Daniel D. , Anderson Kayli , Angert Amy L. , Fishman Lila 
Published: May 2021

PremiseAcross taxa, vegetative and floral traits that vary along a fast‐slow life‐history axis are often correlated with leaf functional traits arrayed along the leaf economics spectrum, suggesting a constrained set of adaptive trait combinations. Such broad‐scale convergence may arise from genetic constraints imposed by pleiotropy (or tight linkage) within species, or from natural selection alone. Understanding the genetic basis of trait syndromes and their components is key to distinguishing these alternatives and predicting evolution in novel environments.MethodsWe used a line‐cross approach and quantitative trait locus (QTL) mapping to characterize the genetic basis of twenty leaf functional/physiological, life history, and floral traits in hybrids between annualized and perennial populations of scarlet monkeyflower (Mimulus cardinalis).ResultsWe mapped both single and multi‐trait QTLs for life history, leaf function and reproductive traits, but found no evidence of genetic co‐ordination across categories. A major QTL for three leaf functional traits (thickness, photosynthetic rate, and stomatal resistance) suggests that a simple shift in leaf anatomy may be key to adaptation to seasonally dry habitats.ConclusionsOur results suggest that the co‐ordination of resource‐acquisitive leaf physiological traits with a fast life‐history and more selfing mating system results from environmental selection rather than functional or genetic constraint. Independent assortment of distinct trait modules, as well as a simple genetic basis to leaf physiological traits associated with drought escape, may facilitate adaptation to changing climates.
Expanding the genotypic spectrum of PYCR2 and a common ancestry in Thai patients with hypomyelinating leukodystrophy 10
Authors: Manaspon Chawan , Boonsimma Ponghatai , Phokaew Chureerat , Theerapanon Thanakorn , Sriwattanapong Kanokwan , Porntaveetus Thantrira , Shotelersuk Vorasuk 
Published: May 2021

AbstractPYCR2 pathogenic variants lead to an autosomal recessive hypomyelinating leukodystrophy 10 (HLD10), characterized by global developmental delay, microcephaly, facial dysmorphism, movement disorder, and hypomyelination. This study identified the first two unrelated Thai patients with HLD10. Patient 1 harbored the novel compound heterozygous variants, c.257T>G (p.Val86Gly) and c.400G>A (p.Val134Met), whereas patient 2 possessed the homozygous variant, c.400G>A (p.Val134Met), in PYCR2. Haplotype analysis revealed that the two families' members shared a 2.3 Mb region covering the c.400G>A variant, indicating a common ancestry. The variant was estimated to age 1450 years ago. Since the c.400G>A was detected in three out of four mutant alleles and with a common ancestry, this variant might be common in Thai patients. We also reviewed the phenotype and genotype of all 35 previously reported PYCR2 patients and found that majorities of cases were homozygous with a consanguineous family history, except patient 1 and another reported case who were compound heterozygous. All patients had microcephaly and developmental delay. Hypotonia and peripheral spasticity were common. Hypomyelination or delayed myelination was a typical radiographic feature. Here, we report the first two Thai patients with HLD10 with the novel PYCR2 variants expanding the genotypic spectrum and suggest that the c.400G>A might be a common mutation in Thai patients.