bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between patellofemoral finite helical axis and femoral trans-epicondylar axis using a static magnetic resonance-based methodology
Authors: Yu Zhenguo , Cai Hong , Yang Bin , Yao Jie , Zhang Ke , Tian Hua , Liu Zhongjun 
Published: March 2021

Abstract
Background
To manage patellofemoral joint disorders, a complete understanding of the in vivo patellofemoral kinematics is critical. However, as one of the parameters of joint kinematics, the location and orientation of the patellofemoral finite helical axis (FHA) remains unclear. The purpose of this study is to quantify the location and orientation of the patellar FHA, both in vivo and non-invasively at various flexion angles, and evaluate the relationship of the FHA and the trans-epicondylar axis (TEA).

Methods
The magnetic resonance (MR) images of 18 unilateral knees were collected at full extension, 30°, 60°, 90°, and maximum angle of knee flexion. Three-dimensional models of the knee joint at different flexion angles were created using the MR images, and then used to calculate the patellar tracking and FHA with a spline interpolation algorithm. By using a coordinate system based on the TEA, the FHA tracking was quantified. Six parameters concerning the location and orientation of the patellar FHA were analysed.

Results
The average patellar FHA drew an L-shaped tracking on the midsagittal plane moving from the posteroinferior to the anterosuperior side of the TEA with knee flexion. Before 90° flexion, the patellar rotational radius decreased slightly, with an average value of 5.65 ± 1.09 cm. During 20° to 90° knee flexion, the average angle between the patellar FHA and the TEA was approximately 10° and that between the FHA and the coronal plane was maintained at about 0°, while that between the FHA and the level plane fluctuated between − 10° and 10°.

Conclusions
This study quantitatively reported the continuous location and direction of the patellar FHA during knee flexion. The patellar FHA was close to but not coincident with the femoral TEA both in location and orientation, and the patellar rotational radius decreased slightly with knee flexion. These findings could provide a clear direction for further studies on the difference in patellofemoral FHA among various types of patellofemoral disorders, and provide a foundation for the application of FHA in surgical evaluation, preoperative planning and prosthesis design, thereby assisting in the diagnosis and treatment of patellofemoral disorders.
Biomechanics of artificial pedicle fixation in a 3D-printed prosthesis after total en bloc spondylectomy: a finite element analysis
Authors: Wang Xiaodong , Xu Hanpeng , Han Ye , Wu Jincheng , Song Yang , Jiang Yuanyuan , Wang Jianzhong , Miao Jun 
Published: March 2021

Abstract
Background
This study compared the biomechanics of artificial pedicle fixation in spine reconstruction with a 3-dimensional (3D)-printed prosthesis after total en bloc spondylectomy (TES) by finite element analysis.

Methods
A thoracolumbar (T10–L2) finite element model was developed and validated. Two models of T12 TES were established in combination with different fixation methods: Model A consisted of long-segment posterior fixation (T10/11, L1/2) + 3D-printed prosthesis; and Model B consisted of Model A + two artificial pedicle fixation screws. The models were evaluated with an applied of 7.5 N·m and axial force of 200 N. We recorded and analyzed the following: (1) stiffness of the two fixation systems, (2) hardware stress in the two fixation systems, and (3) stress on the endplate adjacent to the 3D-printed prosthesis.

Results
The fixation strength of Model B was enhanced by the screws in the artificial pedicle, which was mainly manifested as an improvement in rotational stability. The stress transmission of the artificial pedicle fixation screws reduced the stress on the posterior rods and endplate adjacent to the 3D-printed prosthesis in all directions of motion, especially in rotation.

Conclusions
After TES, the posterior long-segment fixation combined with the anterior 3D printed prosthesis could maintain postoperative spinal stability, but adding artificial pedicle fixation increased the stability of the fixation system and reduced the risk of prosthesis subsidence and instrumentation failure.
Role of glioblastoma stem cells in cancer therapeutic resistance: a perspective on antineoplastic agents from natural sources and chemical derivatives
Authors: Alves Ana Laura V. , Gomes Izabela N. F. , Carloni Adriana C. , Rosa Marcela N. , da Silva Luciane S. , Evangelista Adriane F. , Reis Rui Manuel , Silva Viviane Aline O. 
Published: March 2021

AbstractGlioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior. Despite significant advances in diagnosis and therapy in recent decades, the outcomes for high-grade gliomas (WHO grades III-IV) remain unfavorable, with a median overall survival time of 15–18 months. The concept of cancer stem cells (CSCs) has emerged and provided new insight into GBM resistance and management. CSCs can self-renew and initiate tumor growth and are also responsible for tumor cell heterogeneity and the induction of systemic immunosuppression. The idea that GBM resistance could be dependent on innate differences in the sensitivity of clonogenic glial stem cells (GSCs) to chemotherapeutic drugs/radiation prompted the scientific community to rethink the understanding of GBM growth and therapies directed at eliminating these cells or modulating their stemness. This review aims to describe major intrinsic and extrinsic mechanisms that mediate chemoradioresistant GSCs and therapies based on antineoplastic agents from natural sources, derivatives, and synthetics used alone or in synergistic combination with conventional treatment. We will also address ongoing clinical trials focused on these promising targets. Although the development of effective therapy for GBM remains a major challenge in molecular oncology, GSC knowledge can offer new directions for a promising future.
NRF2 is required for structural and metabolic maturation of human induced pluripotent stem cell-derived ardiomyocytes
Authors: Zhang Xinyuan , Ye Liang , Xu Hao , Zhou Qin , Tan Bin , Yi Qin , Yan Liang , Xie Min , Zhang Yin , Tian Jie , Zhu Jing 
Published: March 2021

Abstract
Background
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great promise for regenerative medicine and in drugs screening. Despite displaying key cardiomyocyte phenotypic characteristics, they more closely resemble fetal/neonatal cardiomyocytes and are still immature; these cells mainly rely on glucose as a substrate for metabolic energy, while mature cardiomyocytes mainly employ oxidative phosphorylation of fatty acids. Studies showed that the alteration of metabolism pattern from glycolysis to oxidative phosphorylation improve the maturity of hiPSC-CMs. As a transcription factor, accumulating evidences showed the important role of NRF2 in the regulation of energy metabolism, which directly regulates the expression of mitochondrial respiratory complexes. Therefore, we hypothesized that NRF2 is involved in the maturation of hiPSC-CMs.

Methods
The morphological and functional changes related to mitochondria and cell maturation were analyzed by knock-down and activation of NRF2.

Results
The results showed that the inhibition of NRF2 led to the retardation of cell maturation. The activation of NRF2 leads to a more mature hiPSC-CMs phenotype, as indicated by the increase of cardiac maturation markers, sarcomere length, calcium transient dynamics, the number and fusion events of mitochondria, and mitochondrial respiration. Bioinformatics analysis showed that in addition to metabolism-related genes, NRF2 also activates the expression of myocardial ion channels.

Conclusions
These findings indicated that NRF2 plays an important role in the maturation of hiPSC-CMs. The present work provides greater insights into the molecular regulation of hiPSC-CMs metabolism and theoretical basis in drug screening, disease modeling, and alternative treatment.
Advances in intranasal application of stem cells in the treatment of central nervous system diseases
Authors: Zhang Yu-Ting , He Kai-Jie , Zhang Jin-Bao , Ma Quan-Hong , Wang Fen , Liu Chun-Feng 
Published: March 2021

AbstractStem cells are characterized by their self-renewal and multipotency and have great potential in the therapy of various disorders. However, the blood–brain barrier (BBB) limits the application of stem cells in the therapy of neurological disorders, especially in a noninvasive way. It has been shown that small molecular substances, macromolecular proteins, and even stem cells can bypass the BBB and reach the brain parenchyma following intranasal administration. Here, we review the possible brain-entry routes of transnasal treatment, the cell types, and diseases involved in intranasal stem cell therapy, and discuss its advantages and disadvantages in the treatment of central nervous system diseases, to provide a reference for the application of intranasal stem cell therapy.
Power equipment fault information acquisition system based on Internet of things
Authors: Wang Ruilian , Li Minghai 
Published: March 2021

AbstractWith the advent of the Internet of things era, power equipment is gradually connected to the network, and its intelligent fault detection function provides greater help for the power industry. The purpose of this study is to design the power equipment fault information acquisition system of the Internet of things. This research is based on the equipment fault information collection system of the Internet of things and mainly studies the fault information collection method based on the Internet of things technology. Equipment fault data are generally time series data. In the analysis of equipment failure, the data before and after fault and before and after fault are analyzed. The abnormal state of equipment is associated with the data before and after the fault. Therefore, by analyzing the characteristics of the fault data and the equipment before and after the fault, a bidirectional recurrent neural network model based on LSTM is constructed. The method designed in this paper can not only improve the efficiency and speed of collection, but also can compare and collect fault information. The overall operation state of the power unit is improved accurately. The research results show that the company's low-voltage user acquisition success rate has reached more than 99%. With the increase of time, the fault information collection efficiency can approach 99%. It shows that the function of this research system is better, the economic loss of the company is reduced, and the management is optimized.
A cut finite element method for spatially resolved energy metabolism models in complex neuro-cell morphologies with minimal remeshing
Authors: Farina Sofia , Claus Susanne , Hale Jack S. , Skupin Alexander , Bordas Stéphane P. A. 
Published: March 2021

AbstractA thorough understanding of brain metabolism is essential to tackle neurodegenerative diseases. Astrocytes are glial cells which play an important metabolic role by supplying neurons with energy. In addition, astrocytes provide scaffolding and homeostatic functions to neighboring neurons and contribute to the blood–brain barrier. Recent investigations indicate that the complex morphology of astrocytes impacts upon their function and in particular the efficiency with which these cells metabolize nutrients and provide neurons with energy, but a systematic understanding is still elusive. Modelling and simulation represent an effective framework to address this challenge and to deepen our understanding of brain energy metabolism. This requires solving a set of metabolic partial differential equations on complex domains and remains a challenge. In this paper, we propose, test and verify a simple numerical method to solve a simplified model of metabolic pathways in astrocytes. The method can deal with arbitrarily complex cell morphologies and enables the rapid and simple modification of the model equations by users also without a deep knowledge in the numerical methods involved. The results obtained with the new method (CutFEM) are as accurate as the finite element method (FEM) whilst CutFEM disentangles the cell morphology from its discretisation, enabling us to deal with arbitrarily complex morphologies in two and three dimensions.
A survey of dimension reduction and classification methods for RNA-Seq data on malaria vector
Authors: Arowolo Micheal Olaolu , Adebiyi Marion Olubunmi , Aremu Charity , Adebiyi Ayodele A. 
Published: March 2021

AbstractRecently unique spans of genetic data are produced by researchers, there is a trend in genetic exploration using machine learning integrated analysis and virtual combination of adaptive data into the solution of classification problems. Detection of ailments and infections at early stage is of key concern and a huge challenge for researchers in the field of machine learning classification and bioinformatics. Considerate genes contributing to diseases are of huge dispute to a lot of researchers. This study reviews various works on Dimensionality reduction techniques for reducing sets of features that groups data effectively with less computational processing time and classification methods that contributes to the advances of RNA-Sequencing approach.
Feasibility and acceptability of an online mindfulness-based group intervention for adults with tic disorders
Authors: Reese Hannah E. , Brown W. Alan , Summers Berta J. , Shin Jin , Wheeler Grace , Wilhelm Sabine 
Published: March 2021

Abstract

Background
Preliminary research suggests that a mindfulness-based treatment approach may be beneficial for adults with tic disorders. In the present study, we report on the feasibility, acceptability, safety, and symptomatic effect of a novel online mindfulness-based group intervention for adults with Tourette syndrome or persistent tic disorder. Data from this study will directly inform the conduct of a funded randomized controlled trial comparing the efficacy of this intervention to another active psychological intervention.

Methods
One cohort of adults with Tourette syndrome participated in an 8-week online mindfulness-based group intervention. Measures of feasibility, acceptability, and safety were administered throughout and at posttreatment. Self-reported measures of mindfulness and clinician-rated measures of tic severity and impairment were administered at baseline and posttreatment.

Results
Data on refusal, dropout rate, attendance, participant satisfaction, and safety suggest that this is a feasible and acceptable intervention. However, participant adherence to home practice was lower than anticipated. Mindfulness, tic severity, and tic-related impairment only modestly improved from baseline to posttreatment. Qualitative analysis of participant feedback revealed aspects of the intervention that were most helpful and also areas for improvement.

Conclusions
Data suggest that although this is a feasible and acceptable intervention, it should be modified to enhance participant adherence, more successfully engage the target mechanism, and optimize outcomes.

Trial registration
Clinicaltrials.gov registration #NCT03525626. Registered on 24 April 2018
Location probability learning in 3-dimensional virtual search environments
Authors: Sisk Caitlin A. , Interrante Victoria , Jiang Yuhong V. 
Published: March 2021

AbstractWhen a visual search target frequently appears in one target-rich region of space, participants learn to search there first, resulting in faster reaction time when the target appears there than when it appears elsewhere. Most research on this location probability learning (LPL) effect uses 2-dimensional (2D) search environments that are distinct from real-world search contexts, and the few studies on LPL in 3-dimensional (3D) contexts include complex visual cues or foraging tasks and therefore may not tap into the same habit-like learning mechanism as 2D LPL. The present study aimed to establish a baseline evaluation of LPL in controlled 3D search environments using virtual reality. The use of a virtual 3D search environment allowed us to compare LPL for information within a participant’s initial field of view to LPL for information behind participants, outside of the initial field of view. Participants searched for a letter T on the ground among letter Ls in a large virtual space that was devoid of complex visual cues or landmarks. The T appeared in one target-rich quadrant of the floor space on half of the trials during the training phase. The target-rich quadrant appeared in front of half of the participants and behind the other half. LPL was considerably greater in the former condition than in the latter. This reveals an important constraint on LPL in real-world environments and indicates that consistent search patterns and consistent egocentric spatial coding are essential for this form of visual statistical learning in 3D environments.
The illusion of absence: how a common feature of magic shows can explain a class of road accidents
Authors: Ekroll Vebjørn , Svalebjørg Mats , Pirrone Angelo , Böhm Gisela , Jentschke Sebastian , van Lier Rob , Wagemans Johan , Høye Alena 
Published: March 2021

AbstractThe purpose of the present note is to draw attention to the potential role of a recently discovered visual illusion in creating traffic accidents. The illusion consists in a compelling and immediate experience that the space behind an occluding object in the foreground is empty. Although the illusion refers to a region of space, which is invisible due to occlusion (a blind spot), there is evidence to suggest that it is nevertheless driven by visual mechanisms and that it can be just as deceptive and powerful as ordinary visual illusions. We suggest that this novel illusion can make situations involving blind spots in a road user's field of view even more dangerous than one would expect based on the lack of visibility by itself. This could be because it erroneously makes the road user feel that (s)he has actually seen everything there is to see, and thus has verified that the blind spot is empty. This hypothesis requires further testing before definitive conclusions can be drawn, but we wish to make researchers and authorities involved in the analysis of traffic accidents and on-the-spot crash investigations aware of its potential role in order to encourage registration of relevant data and facilitate further research.
Nano-imprinted subwavelength gratings as polarizing beamsplitters
Authors: Wüster Julian , Bourgin Yannick , Feßer Patrick , Behrens Arne , Sinzinger Stefan 
Published: March 2021

AbstractPolarizing beamsplitters have numerous applications in optical systems, such as systems for freeform surface metrology. They are classically manufactured from birefringent materials or with stacks of dielectric coatings. We present a binary subwavelength-structured form-birefringent diffraction grating, which acts as a polarizing beamsplitter for a wide range of incidence angles −30∘…+30∘. We refine the general design method for such hybrid gratings. We furthermore demonstrate the manufacturing steps with Soft-UV-Nanoimprint-Lithography, as well as the experimental verification, that the structure reliably acts as a polarizing beamsplitter. The experimental results show a contrast in efficiency for TE- and TM-polarization of up to 1:18 in the first order, and 34:1 in the zeroth order. The grating potentially enables us to realize integrated compact optical measurement systems, such as common-path interferometers.
Transarterial embolization with N-butyl 2-cyanoacrylate for the treatment of recurrent secondary post-tonsillectomy hemorrhage
Authors: Awad Ahmad Sayed , Nassef Amr A. , Mashhour Shady Nabil 
Published: March 2021

Abstract
Background
Postoperative hemorrhage is a potential complication of tonsillectomy, and early diagnosis and adequate management are mandatory to prevent hemorrhagic shock. The aim of this study was to assess the safety and efficacy of transcatheter embolization of recurrent post-tonsillectomy hemorrhage by using N-butyl 2-cyanoacrylate.

Results
We performed a retrospective analysis of the medical records, imaging findings, technical details, and clinical outcome of eight patients with delayed post-tonsillectomy hemorrhage who underwent endovascular embolization. All patients were followed up; technical and clinical successes of treatment were evaluated. All patients had arterial pseudoaneurysm as a source of bleeding. The injured artery was facial artery in four patients, lingual artery in three patients, and linguofacial trunk in one patient. All lesions were treated by endovascular embolization using NBCA glue. All patients were successfully embolized with no clinical complications. In one patient with pseudoaneurysm at the ostium of the facial artery, after filling the pseudoaneurysm with glue, inadvertently proximal reflux into the adjacent part of the external carotid artery (ECA) occurred leading to its occlusion with no related immediate or delayed complication.

Conclusion
Endovascular embolization is an effective and almost safe procedure in the management of recurrent post-tonsillectomy bleeding. In such cases, we can use NBCA glue with certain precautions as an effective appropriate embolizing agent.
Collaborative chronic care model implementation within outpatient behavioral health care teams: qualitative results from a multisite trial using implementation facilitation
Authors: Sullivan Jennifer L. , Kim Bo , Miller Christopher J. , Elwy A. Rani , Drummond Karen L. , Connolly Samantha L. , Riendeau Rachel P. , Bauer Mark S. 
Published: March 2021

Abstract
Background
This paper reports on a qualitative evaluation of a hybrid type II stepped-wedge, cluster randomized trial using implementation facilitation to implement team-based care in the form of the collaborative chronic care model (CCM) in interdisciplinary outpatient mental health teams. The objective of this analysis is to compare the alignment of sites’ clinical processes with the CCM elements at baseline (time 1) and after 12 months of implementation facilitation (time 2) from the perspective of providers.

Methods
We conducted semi-structured interviews to assess the extent to which six CCM elements were in place: work role redesign, patient self-management support, provider decision support, clinical information systems, linkages to community resources, and organizational/leadership support. Interviews were transcribed and a priori CCM elements were coded using a directed content analysis approach at times 1 and 2. We sought consensus on, and compared, the extent to which each CCM element was in place at times 1 and 2.

Results
We conducted 27 and 31 telephone interviews at times 1 and 2, respectively, with outpatient mental health providers at nine participating sites. At time 1 and time 2, three CCM elements were most frequently present across the sites: work role redesign, patient self-management support, and provider decision support. The CCM elements with increased implementation from time 1 to time 2 were work role redesign, patient self-management support, and clinical information systems. For two CCM elements, linkages to community resources and organizational/leadership support, some sites had increased implementation at time 2 compared to time 1, while others had reductions. For the provider decision support element, we saw little change in the extent of its implementation.

Conclusions
Sites increased the extent of implementation on several CCM elements. The most progress was made in the CCM elements where sites had CCM-aligned processes in place at time 1. Teams made progress on elements they could more easily control, such as work role redesign. Our results suggest that maximizing the benefits of CCM-based outpatient mental health care may require targeting resources and training toward specific CCM elements—especially in the use of clinical information systems and linking with community resources.

Trial registration
Clinical Trials NCT02543840.