bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk assessment of Cretaceous water inrush in the Ordos Basin based on the FAHP-EM
Authors: Zhu Tingen , Li Wenping , Chen Weichi 
Published: September 2021

Abstract
A study on the risk of Cretaceous water inrush in the Ordos Basin in China is of great significance to the safe production and environmental protection of the western coal seam. This paper selects the following five key influencing factors for Cretaceous water inrush: the coal seam mining thickness, rock quality designation, distance between the top boundary of the water-conducting fracture zone and the bottom boundary of the Cretaceous system, the thickness of the Cretaceous aquifer, and the height of the water head. Furthermore, based on an analysis of geological and hydrogeological conditions of the Yingpanhao coal mine, the comprehensive weights of these factors were found using a fuzzy analytic hierarchy process and the entropy method (FAHP-EM) to be 0.27, 0.25, 0.22, 0.08, and 0.18, respectively. This paper describes the use of ArcGIS's spatial overlay analysis to create a risk assessment zoning map using these weightings. By comparing the evaluation results of the FAHP-EM and the water inrush coefficient method, it is shown that the FAHP-EM provides additional insight in assessing the risk of coal seam roof water inrush. The research results of this paper provide a theoretical basis for coal mining safety in western China to assess water inrush.
Experimental study of the rheology of water–kaolinite suspensions
Authors: Zhu Zhongfan 
Published: September 2021

Abstract
How the added electrolyte condition and size of primary sediment particles, as well as the particle concentration, affect the rheological behaviours of water–sediment suspension remains to be of interest in the sediment field. In this work, rheological experiments of water–kaolinite suspensions with different electrolyte conditions, two particle sizes and 39 solid concentrations were performed. The Bingham fluid model has been adopted to fit the experimental data, and the viscosity and Bingham shear stress values were calculated for each suspension. It has been found that an increase in electrolyte concentration and/or valence leads to a larger viscosity value of the suspension, whereas an increase in electrolyte valence yields a smaller Bingham shear stress value. A simple interpretation based on DLVO theory was presented in this study. It has also been observed that a fine-grained kaolinite suspension corresponds to larger suspension viscosity and Bingham shear stress values. Additionally, some experimental information on the viscosity–solid concentration and Bingham shear stress–solid concentration relationships were also presented in this study. For the viscosity–solid concentration data, the Krieger and Dougherty formula provided the best fit, and a simple exponential relation showed a good fit for the measured shear stress–solid concentration data.
Gold Nanoparticles in Triple-Negative Breast Cancer Therapeutics
Authors: Akter Zakia , Khan Fabiha Zaheen , Khan Md. Asaduzzaman 
Published: September 2021

Background:
Triple-negative breast cancer (TNBC) is the most aggressive
type of breast cancer with enhanced metastasis and poor survival. Though chemotherapy,
radiotherapy, photothermal therapy (PTT), photodynamic therapy (PDT), and gene delivery
are used to treat TNBC, various side effects limit these therapeutics against TNBC. In
this review article, we have focused on the mechanism of action of gold nanoparticles
(AuNPs) to enhance the efficacy of therapeutics with targeted delivery on TNBC cells.

Methods:
Research data were accumulated from PubMed, Scopus, Web of Science, and
Google Scholar using searching criteria “gold nanoparticles and triple-negative breast
cancer” and “gold nanoparticles and cancer”. Though we reviewed many old papers, the
most cited papers were from the last ten years.

Results:
Various studies indicate that AuNPs can enhance bioavailability, site-specific
drug delivery, and efficacy of chemotherapy, radiotherapy, PTT, and PDT as well as
modulate gene expression. The role of AuNPs in the modulation of TNBC therapeutics
through the inhibition of cell proliferation, progression, and metastasis has been proved in
vitro and in vivo studies. As these mechanistic actions of AuNPs are most desirable to develop
drugs with enhanced therapeutic efficacy against TNBC, it might be a promising
approach to apply AuNPs for TNBC therapeutics.

Conclusion:
This article reviewed the mechanism of action of AuNPs and their application
in the enhancement of therapeutics against TNBC. Much more attention is required
for studying the role of AuNPs in developing them either as a single or synergistic anticancer
agent against TNBC.
Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement
Authors: Alt Jesse , Gori Sadakatali S. , Lemberg Kathryn M. , Pal Arindom , Veeravalli Vijayabhaskar , Wu Ying , Aguilar Joanna M.H. , Dash Ranjeet P. , Tenora Lukáš , Majer Pavel , Sun Qi , Slusher Barbara S. , Rais Rana 
Published: September 2021

Background:
Metabolomic analyses from our group and others have shown that tumors treated with glutamine
antagonists (GA) exhibit robust accumulation of formylglycinamide ribonucleotide (FGAR), an intermediate
in the de novo purine synthesis pathway. The increase in FGAR is attributed to the inhibition of the enzyme FGAR
amidotransferase (FGAR-AT) that catalyzes the ATP-dependent amidation of FGAR to formylglycinamidine ribonucleotide
(FGAM). While perturbation of this pathway resulting from GA therapy has long been recognized, no study
has reported systematic quantitation and analyses of FGAR in plasma and tumors.

Objective:
Herein, we aimed to evaluate the efficacy of our recently discovered tumor-targeted GA prodrug, GA-607
(isopropyl 2-(6-acetamido-2-(adamantane-1-carboxamido)hexanamido)-6-diazo-5-oxohexanoate), and demonstrate
its target engagement by quantification of FGAR in plasma and tumors.

Methods:
Efficacy and pharmacokinetics of GA-607 were evaluated in a murine EL4 lymphoma model followed by
global tumor metabolomic analysis. Liquid chromatography-mass spectrometry (LC-MS) based methods employing
the ion-pair chromatography approach were developed and utilized for quantitative FGAR analyses in plasma and
tumors.

Results:
GA-607 showed preferential tumor distribution and robust single-agent efficacy in a murine EL4 lymphoma
model. While several metabolic pathways were perturbed by GA-607 treatment, FGAR showed the highest increase
qualitatively. Using our newly developed sensitive and selective LC-MS method, we showed a robust >80- and >10-
fold increase in tumor and plasma FGAR levels, respectively, with GA-607 treatment.

Conclusion:
These studies describe the importance of FGAR quantification following GA therapy in cancer and
underscore its importance as a valuable pharmacodynamic marker in the preclinical and clinical development of GA
therapies.
Health Benefits of Avicularin in the Medicine Against Cancerous Disorders
and other Complications: Biological Importance, Therapeutic Benefit
and Analytical Aspects
Authors: Patel Dinesh Kumar , Patel Kanika 
Published: September 2021

Background:
Herbal drugs and their derived phytochemicals have been used in
medicine for the preparation of different types of pharmaceutical products. Pure phytochemicals including
flavonoids, alkaloids and terpenoids have been used in medicine for the treatment of different
types of human disorders including cancerous disorders. Flavonoids have been well known in
medicine for their anti-viral, anti-bacterial, anti-inflammatory, anti-diabetic, anti-cancer, anti-aging
and cardioprotective potential. Avicularin, also called quercetin-3-α-l-arabino furanoside, is a pure
flavonoid, a class of phytochemicals, found to be present in Lindera erythrocarpa and Lespedeza
cuneata. Avicularin has been well known in medicine for its anti-cancer properties.

Methods:
In the present work, scientific data of avicularin have been collected from different
databases such as Google, PubMed, Science Direct, Google Scholar and Scopus and summarized
with reference to medicinal importance, pharmacological activities and analytical aspects of avicularin.
The present review summarized the health beneficial properties of avicularin in medicine
through data analysis of various scientific research works. Further analytical progress in medicine
for the qualitative and quantitative analysis of avicularin in medicine has been also discussed in the
present work.

Results:
Scientific data analysis of different literature work revealed the biological importance of
flavonoid class of phytochemical ‘avicularin’ in medicine. Scientific data analysis revealed that avicularin
was found to be present in the Lindera erythrocarpa, Lespedeza cuneata, Rhododendron
schlipenbachii and Psidium guajava. Avicularin has been well known in medicine for its anti-inflammatory,
anti-allergic, anti-oxidant, anti-tumor and hepatoprotective activities. Avicularin protects
cardiomyocytes and hepatocytes against oxidative stress-induced apoptosis and induces cytotoxicity
in cancer lines and tumor tissues. Avicularin has positive influence on human hepatocellular
carcinoma and inhibits intracellular lipid accumulation. The role of avicularin in rheumatoid
arthritis has been also established with its underlying molecular mechanisms in the scientific work.
Recent interest in avicularin has focused on pharmacological investigations for its anti-cancer activity
in the medicine.

Conclusion:
The present work signified the biological importance of avicularin in medicine
through its medicinal uses, pharmacological activities and analytical aspects in the biological system.
Structural Perspectives and Advancement of SGLT2 Inhibitors for the Treatment of Type 2 Diabetes
Authors: Sharma Shivani , Mittal Amit , Kumar Shubham , Mittal Anu 
Published: September 2021

Abstract:Diabetes mellitus is an ailment that affects a large number of individuals worldwide and its pervasiveness has been predicted to increase later on. Every year, billions of dollars are spent globally on diabetes-related health care practices. Contemporary hyperglycemic therapies to rationalize Type 2 Diabetes Mellitus (T2DM) mostly involve pathways that are insulin-dependent and lack effectiveness as the pancreas’ β-cell function declines more significantly. Homeostasis via kidneys emerges as a new and future strategy to minimize T2DM complications. This article covers the reabsorption of glucose mechanism in the kidneys, the functional mechanism of various Sodium- Glucose Cotransporter 2 (SGLT2) inhibitors, their structure and driving profile, and a few SGLT2 inhibitors now accessible in the market as well as those in different periods of advancement. The advantages of SGLT2 inhibitors are dose-dependent glycemic regulation changes with a significant reduction both in the concentration of HbA1c and body weight clinically and statistically. A considerable number of SGLT2 inhibitors have been approved by the FDA, while a few others, still in preliminaries, have shown interesting effects.
Sacubitril/Valsartan: A New Dawn has Begun! A Revisited Review
Authors: Abdelnabi Mahmoud , Saleh Yehia , Almaghraby Abdallah , Girgis Hany , Gerges Fady 
Published: September 2021

:
Heart Failure (HF) is among the major causes of global morbidity as well as mortality.
Increased prevalence, frequent and prolonged hospitalization, rehospitalization, long-term consumption
of healthcare resources, absenteeism, and death upsurge the economic burden linked to
HF. For decades, Angiotensin-Converting Enzyme Inhibitors (ACEIs), Angiotensin II Receptor
Blockers (ARBs), Beta-Blockers (BBs), and mineralocorticoid receptor antagonists (MRA), have
remained the mainstay of the standard of care for HF management. Despite their proven efficacy
and cost-effectiveness, HF remains a global pandemic and is still increasing in prevalence. Sacubitril/
Valsartan (SAC/VAL) is an Angiotensin Receptor/Neprilysin Inhibitor (ARNI) that proved out
to be a game-changer drug in HF treatment. Recent data indicated that SAC/VAL is more efficient
and can improve the overall quality of life of HF patients with reduced ejection fraction (HFrEF)
with fewer side effects. It is now incorporated in the guidelines as an alternative to ACEIs or ARBs
to lower morbidity in addition to mortality in HFrEF patients. This review article will discuss the
current guidelines-approved indications and highlight the potential emerging indications, in addition
to the currently ongoing clinical trials that will expand the use of SAC/VAL.
Novel Non-pharmaceutical Advancements in Heart Failure Management:
The Emerging Role of Technology
Authors: Nolan Mark T. , Tan Neville , Neil Christopher J. 
Published: September 2021

Purpose of Review:
To summarise and discuss the implications of recent technological
advances in heart failure care.

Recent Findings:
Heart failure remains a significant source of morbidity and mortality in the US
population despite multiple classes of approved pharmacological treatments. Novel cardiac devices
and technologies may offer an opportunity to improve outcomes. Baroreflex Activation Therapy
and Cardiac Contractility Remodelling may improve myocardial contractility by altering neurohormonal
stimulation of the heart. Implantable Pulmonary Artery Monitors and Biatrial Shunts may
prevent heart failure admissions by altering the trajectory of progressive congestion. Phrenic Nerve
Stimulation offers potentially effective treatment for comorbid conditions. Smartphone applications
offer an intriguing strategy for improving medication adherence.

Summary:
Novel heart failure technologies offer promise for reducing this public health burden.
Randomized controlled studies are indicated for assessing the future role of these novel therapies.
Prevalence Estimates, Severity, and Risk Factors of Depressive Symptoms among Coronary Artery Disease Patients after Ten Days of Percutaneous Coronary Intervention
Authors: Rawashdeh Sukaina I. , Ibdah Rasheed , Kheirallah Khalid A. , Al-kasasbeh Abdullah , Raffee Liqaa A. , Alrabadi Nasr , Albustami Iyad S. , Haddad Rabia , Ibdah Raed M. , Al-Mistarehi Abdel-Hameed 
Published: September 2021

Background:
Depression and cardiovascular disorders are significant determinants of health that affect the quality of life and life expectations. Despite the high importance of depression screening among Coronary Artery Disease (CAD) patients, the time being to assess and treat it remains controversial.

Objectives:
This study aims to assess the prevalence estimates and severity of depressive symptoms and determine the risk factors associated with developing such symptoms among CAD patients after ten days of Percutaneous Coronary Intervention (PCI).

Methods:
All patients who underwent elective PCI between October 5, 2019, and Mid-March 2020 and diagnosed with CAD were included in this cross-sectional study. CAD was defined as intra-luminal stenosis of ≥ 50% in one or more of the coronary arteries. Depressive symptoms were screened after ten days of the PCI utilizing the patient health questionnaire-9 (PHQ-9) tool. A linear regression model was used to assess the adjusted effects of independent variables on PHQ-9 scores. Electronic medical records, clinical charts, and PCI and echocardiogram reports were reviewed.

Results:
Out of 385 CAD patients, a total of 335 were included in this study, with a response rate of 87%. The participants' mean (±SD) age was 57.5±10.7 years, 75.2% were males, 43% were current smokers, and 73.7% had below bachelor's education. The prevalence estimates of patients with moderate to severe depressive symptoms (PHQ-9 ≥10) was 34%, mild depression 45.1%, and normal 20.9%. Female gender, low educational level and diabetes mellitus were found to be the significant independent predictors of depression among our cohort with (t(333) = 3.68, p<0.001); (t(333) = 5.13, p<0.001); and (t(333) = 2.79, p=0.042), respectively.

Conclusion:
This study suggests a high prevalence of depressive symptoms among CAD patients after ten days of PCI. Approximately one out of three patients with CAD have significant symptoms of depression, which is an alarming finding for clinicians. Moreover, this study demonstrates a lack of sufficient depression recognition and management in similar study settings. Integration of mental health assessment and treatment among patients with CAD as soon as after PCI is recommended for optimal and effective treatment and to obtain the best outcomes.
Phytochemical Contents, Biological Activities and Therapeutic Applications
of Hedera Helix (Ivy Leaf) Extracts: A Review
Authors: Shokry Aya , El-Shiekh Riham , Kamel Gehan , Ramadan Amer 
Published: September 2021

Background:
Herbs have long been used as natural therapeutics, and recent controlled
clinical studies have confirmed some of the presumed benefits. Hedera helix(ivy leaves) is a valuable
common form related to the family Araliaceae. Many herbal preparations include extracts
from their leaves as the principle active ingredient.

Objective:
The objective of this article is to summarize the pharmacological activities and phytochemical
screening of H. helix.

Methods:
To prepare this article, the data was collected from different sources, including books, thesis,
research and etc.

Results:
The all-published studies depend on isolation, identification, and characterization of different
active constituents of H. helix leaves, followed by the determination of biological activities in
vivo and in vitro. Chemical screening has shown that H. helix leaves are a rich source of phytochemicals
demonstrating therapeutic activities, such as sterols, tannins, terpenoids, glycosides,
phenols, emetine alkaloids, flavonoids, saponins, volatile and fixed oils, vitamins, carbohydrates,
reducing sugars, and minerals. Further, studies of disease models and clinical trials have demonstrated
anti-inflammatory, analgesic, cough suppressant, expectorant, anticancer, antimicrobial, anticoagulant,
and smooth muscle relaxant activities.

Conclusion:
This review summarizes the bioactive constituents of H. helix leaves and their underlying
pharmacological mechanisms, clinical efficacies, and safety profiles. We also suggest potential
therapeutic uses for COVID-19.
Antiviral Properties of Food Plants could help to Reduce Contagion and
Severity in SARS-CoV-2 Infection
Authors: Cardoso Betina 
Published: September 2021

Introduction:
It is important to find tools to help patients and prevent viral diffusion of
pneumonia caused by the 2019 novel coronavirus (2019-nCoV or SARS-CoV-2). Recent articles
have reported site-specific SARS-CoV-2 infection on a patient's body, specifically a very active replication
in the throat and upper respiratory tract, even at the mild stage of the disease, which
shows its efficient viral transmission in sputum.

Material and Methods:
An alternative that may be feasible is to resort to scientific studies that demonstrate
the antiviral potential of medicinal plants species through in-vitro and in-vivo experiments
to alleviate symptoms and prevent the spread of contagion. A literature search on Scopus
and PubMed on herbs and foods with antiviral properties was performed.

Results:
This resulted in hundreds of publications showing a diversity of plants with antiviral effects
against different virus infections. This article focuses on plants that are of common use,
which could act against COVID-19.

Conclusions:
Herbs and foods with demonstrated antiviral potential have been identified, limiting
SARS-CoV-2 spread by interfering with ACE2 protein on infection sites. The analysis of transdisciplinary
knowledge allows us to connect previous research on the action of common plants and
foods on viruses to limit the replication of SARS-CoV-2 in the throat and upper respiratory tract.
Research Progress on Oil Sludge Treatment in Oilfield: A Mini-Review
Authors: Deng Jinjun , Zhang Huili , Yu Bo , Liu Hongsheng 
Published: September 2021

:
A large amount of sludge produced in the processing of crude oil has brought
great harm. In this paper, common flocculants are summarized. According to the treatment
process of crude oil, flocculants are divided into organic flocculants, inorganic
flocculants, microbial flocculants, composite flocculants, and magnetic flocculants. The
mechanism and limitation of each flocculation on crude oil sludge were analyzed. Finally,
it is pointed out that the flocculation process of sludge is complex, and the development
of new flocculant with high efficiency, safety, and economy is the main trend of
flocculant development in the future.
Analisa Keruntuhan Bendungan Salomekko Kabupaten Bone Dengan Menggunakan Aplikasi Zhong Xing HY21
Authors: Ayu Mirsa , Juwono Pitojo Tri , Asmaranto Runi 
Published: September 2021

Bendungan Salomekko terletak di Dukuh Salomekko Desa Ulu Balang, Kecamatan Salomekko, Kabupaten Bone, Provinsi Sulawesi Selatan yang memiliki fungsi utama untuk menyediakan air bagi kebutuhan irigasi pertanian seluas 1722 Ha. Bendungan Salomekko disamping memiliki manfaat juga menyimpan potensi bahaya, yaitu apabila bendungan runtuh. Oleh karena itu, dibutuhkan analisa keruntuhan bendungan Bendungan Salomekko yang diasumsikan akibat overtopping dan pippingÂ menggunakan aplikasi Zhong Xing HY21. Bedasarkan hasil simulasi melalui aplikasi Zhong Xing HY21, keruntuhan akibat overtopping merupakan peyebab keruntuhan Bendungan Salomekko yang menimbulkan dampak paling besar dengan debit banjir rancangan PMF sebesar 753,862 mÂ³/det dan luas genangan 15,694 km2 dengan tinggi genangan maksimum 7,759 m. Keruntuhan Bendungan Salomekko mengakibatkan 11 desa terdampak pada bagian hilir bendungan dengan jumlah penduduk terkena resiko 2565 jiwa.
Studi Perencanaan Sumur Injeksi Dalam Upaya Penanggulangan Genangan Di Kawasan Perkotaan (Studi Kasus Di RW. 8 Dan 9 â€“ Kelurahan Blimbing, Kota Malang)
Authors: Syafira Annisa Zuyyinani'ma , Bisri Mohammad , Asmaranto Runi 
Published: September 2021

RW.8 and 9 areas, Blimbing Sub-district, Malang city is one of the areas that often occur inundation due to changes in land cover and narrowing of drainage channels. The solution is the manufacture of injection wells to determine the inundation, planning, and effectiveness of injection wells at the research site. To analyze it, modeling rain inundationÂ a return period ofÂ 2 years and 5 years using Storm Water Management Model (SWMM) 5.1 application. Calibration results showed for the Root Mean Square Error (RMSE) value, modeling discharge and measurable discharge for a return period of 2 years is 17.3%, and a return period of 5 years is 20.9%. The simulationÂ results showed the capacity of existing drainage channelsÂ for a return period of 2 years and 5 yearsÂ resulted in 8 channels overflowing from 42 existing channels with the number of injection wells needed as many as 45 injection wells for 8 water catchment areas. The effectiveness value of the application of injection wells using rain barrels obtained results forÂ a return period of 2 years isÂ 66.67%-93.33% with average injection well effectiveness is 84.66% andÂ a return period of 5 yearsÂ is 66%-95% with average injection well effectiveness is 84.78%.Â