bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rise and fall of Stachys annua (L.) L. in the Carpathian Basin: a historical review and prospects for its revival
Authors: Pinke Gyula , Dunai Éva , Czúcz Bálint 
Published: July 2021

AbstractStachys annua(L.) L., a melliferous archaeophyte plant became a dominant weed of the cereal stubbles of the Carpathian Basin in the medieval three-field system. By the middle of the nineteenth century, this plant provided more than two-thirds of the Hungarian honey production, and its high quality monofloral honey turned into a characteristic brand of the Hungarian apiculture. Recognizing its importance,S. annuaalso briefly became a minor crop cultivated in “bee gardens” and arable fields in the late nineteenth century, possibly also in response to the first signs of its upcoming decline. Starting with the advent of the steam plough, the twentieth century has brought a drastic decline forS. annuadue to a combination of deeper and earlier tillage operations, agrochemicals, and new competing weed species (in particular the common ragweed,Ambrosia artemisiifolia). The last remnant stands of this previously dominant weed species are of considerable ecological and historical value as farmland biodiversity hotspots. These sites are important refuge for rare weeds, wild pollinators (including bumblebees), and declining farmland birds, which could be targeted by eco-schemes under the European Union’s (EU’s) greening Common Agricultural Policy. The rediscovery of the cropping potential ofS. annuaand the development of an appropriate technology would also allow its cultivation as a valuable bee forage, catch crop, green cover, or oilseed plant in the future.
Hedonic and Eudaimonic Well-Being in Late Adulthood: Lessons From Sardinia’s Blue Zone
Authors: Fastame Maria Chiara , Ruiu Marilena , Mulas Ilaria 
Published: July 2021

AbstractThis study was conducted to investigate whether socio-cultural context (i.e., urban versus rural), perceived physical health, marital status, and satisfaction with family and non-family ties predicted hedonic and eudaimonic well-being in late adulthood and to examine the impact of the socio-cultural context on well-being, physical health and satisfaction with family and non-family ties by controlling age.One hundred and one community-dwelling participants aged between 68 and 94 were enrolled in the Sardinian Blue Zone—an area of exceptional longevity located in Sardinia, an Italian island in the Mediterranean Sea—and in the city of Cagliari—the regional capital. All participants completed a battery of tools assessing global cognitive efficiency, hedonic (i.e., SPANE and Satisfaction with Life Scales) and eudaimonic (i.e., Flourishing Scale) well-being, perceived physical health, and satisfaction with family and non-family ties. Hedonic and eudaimonic well-being were associated with several variables: marital status, socio-cultural context, and perceived physical health predicted 24% of the variance in the SPANE condition, 52% of the variance in the Satisfaction with Life condition was predicted by the socio-cultural context and satisfaction with family ties, whereas 39% of the Flourishing index was predicted by the socio-cultural context and physical health. Finally, the participants in the Sardinian Blue Zone reported better mental well-being and satisfaction with family and non-family ties than older people living in Cagliari. In conclusion, a socio-cultural context in which positive relationships in late adulthood are strengthened contributes to the promotion of mental health in late adulthood.
Beyond viral suppression: Quality of life among stable ART clients in a differentiated service delivery intervention in Tanzania
Authors: Okere Nwanneka Ebelechukwu , Censi Veronica , Machibya Clementina , Costigan Kathleen , Katambi P. , Martelli Giulia , de Klerk Josien , Hermans Sabine , Gomez Gabriela B. , Pozniak Anton , de Wit Tobias Rinke , Naniche Denise 
Published: July 2021

Abstract
Background
With antiretroviral therapy, more people living with HIV (PLHIV) in resource-limited settings are virally suppressed and living longer. WHO recommends differentiated service delivery (DSD) as an alternative, less resource-demanding way of expanding HIV services access. Monitoring client’s health-related quality of life (HRQoL) is necessary to understand patients’ perceptions of treatment and services but is understudied in sub-Saharan Africa. We assessed HRQoL among ART clients in Tanzania accessing two service models.

Methods
Cross-sectional survey from May–August 2019 among stable ART clients randomly sampled from clinics and clubs in the Shinyanga region providing DSD and clinic-based care. HRQoL data were collected using a validated HIV-specific instrument—Functional Assessment of HIV infection (FAHI), in addition to socio-demographic, HIV care, and service accessibility data. Descriptive analysis of HRQoL, logistic regression and a stepwise multiple linear regression were performed to examine HRQoL determinants.

Results
629 participants were enrolled, of which 40% accessed DSD. Similar HRQoL scores [mean (SD), p-value]; FAHI total [152.2 (22.2) vs 153.8 (20.6), p 0.687] were observed among DSD and clinic-based care participants. Accessibility factors contributed more to emotional wellbeing among DSD participants compared to the clinic-based care participants (53.4% vs 18.5%, p =  < 0.001). Satisfactory (> 80% of maximum score) HRQoL scoring was associated with (OR [95% CI], p-value) being male (2.59 [1.36–4.92], p 0.004) among clinic participants and with urban residence (4.72 [1.70–13.1], p 0.001) among DSD participants.

Conclusions
Similar HRQoL was observed in DSD and clinic-based care. Our research highlights focus areas to identify supporting interventions, ultimately optimizing HRQoL among PLHIV.
Reichenbach's best alternative account to the problem of induction
Authors: Schurz Gerhard 
Published: July 2021

AbstractIn this paper Reichenbach's best alternative account (BAA) to induction is examined. In the first section, three versions of the BAA are distinguished that have been discussed in the literature. The major objections against all three versions are presented. In the second section it is shown by a text analysis that Reichenbach (The theory of probability, University of California Press, California, 1949) argues for all three versions of the BAA and does not sufficiently distinguish between them. In the third section it is explained how Reichenbach's third version of the BAA can be transformed into a provable optimality theorem within the account of meta-induction.
Positron Emission Tomographic Imaging of Tumor Cell Death Using Zirconium-89-Labeled APOMAB® Following Cisplatin Chemotherapy in Lung and Ovarian Cancer Xenograft Models
Authors: Liapis Vasilios , Tieu William , Wittwer Nicole L. , Gargett Tessa , Evdokiou Andreas , Takhar Prab , Rudd Stacey E. , Donnelly Paul S. , Brown Michael P. , Staudacher Alexander H. 
Published: July 2021

Abstract
Purpose
Early detection of tumor treatment responses represents an unmet clinical need with no approved noninvasive methods. DAB4, or its chimeric derivative, chDAB4 (APOMAB®) is an antibody that targets the Lupus associated antigen (La/SSB). La/SSB is over-expressed in malignancy and selectively targeted by chDAB4 in cancer cells dying from DNA-damaging treatment. Therefore, chDAB4 is a unique diagnostic tool that detects dead cancer cells and thus could distinguish between treatment responsive and nonresponsive patients.

Procedures
In clinically relevant tumor models, mice bearing subcutaneous xenografts of human ovarian or lung cancer cell lines or intraperitoneal ovarian cancer xenografts were untreated or given chemotherapy followed 24h later by chDAB4 radiolabeled with [89Zr]ZrIV. Tumor responses were monitored using bioluminescence imaging and caliper measurements. [89Zr]Zr-chDAB4 uptake in tumor and normal tissues was measured using an Albira SI Positron-Emission Tomography (PET) imager and its biodistribution was measured using a Hidex gamma-counter.

Results
Tumor uptake of [89Zr]Zr-chDAB4 was detected in untreated mice, and uptake significantly increased in both human lung and ovarian tumors after chemotherapy, but not in normal tissues.

Conclusion
Given that tumors, rather than normal tissues, were targeted after chemotherapy, these results support the clinical development of chDAB4 as a radiodiagnostic imaging agent and as a potential predictive marker of treatment response.
Klimawandel und Gesundheit – klimabedingte Gesundheitsrisiken im deutschen Sport
Authors: Schneider Sven , Eichinger Michael , Anderson Lilian , Leer Sophie 
Published: July 2021

Zusammenfassung
Hintergrund
Viele Sportler:innen sind von klimabedingten Gesundheitsrisiken besonders betroffen. Vor dem Hintergrund des fortschreitenden Klimawandels sind auch hierzulande präventive Maßnahmen zum Schutz dieser Personengruppe von besonders hoher Relevanz. Dieser Beitrag gibt eine aktuelle Übersicht, inwieweit die deutschen Spitzenverbände Breiten- und Leistungssportler:innen über die gesundheitlichen Auswirkungen des Klimawandels auf ihren zentralen Verbandswebseiten informieren.

Methodik
Im Rahmen einer netnographischen Analyse wurden die Webseiten der 66 im Deutschen Olympischen Sportbund (DOSB) organisierten Spitzenverbände mittels Schlagwortsuche analysiert. Die Inhalte wurden entlang der vom Robert Koch-Institut vorgeschlagenen Differenzierung in direkte und indirekte Folgen des Klimawandels gegliedert. Die doppelte und verblindete Sichtung erfolgte in KW46/20.

Ergebnisse
Die wenigsten im DOSB organisierten Spitzenverbände thematisieren auf ihren Webseiten sportartspezifische Gesundheitsrisiken des Klimawandels. Falls doch, werden Risiken meist eher randständig behandelt. Lediglich jeder sechste Spitzenverband informiert über Hitzewellen und jeder fünfte über UV-Belastungen. Jeweils nur jeder zehnte Verband thematisiert Extremwetterereignisse respektive Infektionsrisiken. Risiken durch Ozon und Allergene werden noch seltener angesprochen. Trotz der Relevanz auch für Indoorsportarten finden sich auf den Webseiten der betreffenden Spitzenverbände keine einschlägigen Informationen.

Schlussfolgerung
Der Klimawandel wird für die große Bevölkerungsgruppe der Sportler:innen ebenso wie für die entsprechenden Sportorganisationen weiter an Bedeutung gewinnen. Der bundesweite Webauftritt der Spitzenverbände wäre ein geeigneter Ort für zielgruppengerechte Gesundheitsinformationen.
Constructed floating wetlands made of natural materials as habitats in eutrophicated coastal lagoons in the Southern Baltic Sea
Authors: Karstens Svenja , Langer Maria , Nyunoya Hayato , Čaraitė Ieva , Stybel Nardine , Razinkovas-Baziukas Arturas , Bochert Ralf 
Published: July 2021

AbstractEutrophication remains an environmental challenge in lagoons along the Southern Baltic Sea. Floating islands planted with emergent macrophytes are an option to remove nutrients from eutrophicated waters. Furthermore, floating wetlands offer other ecosystem services such as the provision of habitats. Numerous scientific studies have been conducted; however most remain on the laboratory scale. This research explores the challenges associated with installations in coastal environments and focuses on sustainability of the island design, the habitat function as well as nutrient removal. Most floating wetland designs use polyethylene, polypropylene, polyurethane or polyvinyl alcohol foam to ensure the buoyancy. For this study an artificial polymer free island design was developed and tested. The floating constructions in the Darss-Zingst-Bodden-Chain were planted with native macrophytes which have the potential to act as ‘biodiversity-supplements’ to the adjacent coastal wetlands:Bolboschoenus maritimus,Carex acutiformis, Iris pseudacorus, Juncus effesus, Lythrum salicaria, Schoenoplectus lacustris, Typha latifolia. The chosen macrophytes survived fluctuating salinities. After three months the above-ground biomass was harvested and analyzed for the nutrient concentrations. Phosphorus concentrations were highest inL. salicariaand nitrogen inI. pseudacorus. Video monitoring and field observations were applied in order to observe animals. Birds did not use the floating wetlands as breeding grounds, but the grey heron (Ardea cinerea) was a common visitor for foraging. Especially surprising was the large amount of juvenile eels (Anguilla anguilla). A diverse and large root network below the floating islands boosts not only nutrient removal but serves as a shelter and refuge for fish such as the endangered eel.
Ethical Artificial Intelligence in Chemical Research and Development: A Dual Advantage for Sustainability
Authors: Hermann Erik , Hermann Gunter , Tremblay Jean-Christophe 
Published: July 2021

AbstractArtificial intelligence can be a game changer to address the global challenge of humanity-threatening climate change by fostering sustainable development. Since chemical research and development lay the foundation for innovative products and solutions, this study presents a novel chemical research and development process backed with artificial intelligence and guiding ethical principles to account for both process- and outcome-related sustainability. Particularly in ethically salient contexts, ethical principles have to accompany research and development powered by artificial intelligence to promote social and environmental good and sustainability (beneficence) while preventing any harm (non-maleficence) for all stakeholders (i.e., companies, individuals, society at large) affected.
Bacteroides uniformis CECT 7771 Modulates the Brain Reward Response to Reduce Binge Eating and Anxiety-Like Behavior in Rat
Authors: Agustí Ana , Campillo Isabel , Balzano Tiziano , Benítez-Páez Alfonso , López-Almela Inmaculada , Romaní-Pérez Marina , Forteza Jerónimo , Felipo Vicente , Avena Nicole M. , Sanz Yolanda 
Published: July 2021

AbstractFood addiction (FA) is characterized by behavioral and neurochemical changes linked to loss of food intake control. Gut microbiota may influence appetite and food intake via endocrine and neural routes. The gut microbiota is known to impact homeostatic energy mechanisms, but its role in regulating the reward system is less certain. We show that the administration of Bacteroides uniformis CECT 7771 (B. uniformis) in a rat FA model impacts on the brain reward response, ameliorating binge eating and decreasing anxiety-like behavior. These effects are mediated, at least in part, by changes in the levels of dopamine, serotonin, and noradrenaline in the nucleus accumbens and in the expression of dopamine D1 and D2 receptors in the prefrontal cortex and intestine. B. uniformis reverses the fasting-induced microbiota changes and increases the abundance of species linked to healthy metabolotypes. Our data indicate that microbiota-based interventions might help to control compulsive overeating by modulating the reward response.
Influence of incorrect staging of colorectal carcinoma on oncological outcome: are we playing safely?
Authors: Reali Claudia , Bocca Gabriele , Lindsey Ian , Jones Oliver , Cunningham Chris , Guy Richard , George Bruce , Boyce Stephen 
Published: July 2021

AbstractAccurate preoperative staging of colorectal cancers is critical in selecting patients for neoadjuvant therapy prior to resection. Inaccurate staging, particularly understaging, may lead to involved resection margins and poor oncological outcomes. Our aim is to determine preoperative imaging accuracy of colorectal cancers compared to histopathology and define the effect of inaccurate staging on patient selection for neoadjuvant treatment(NT). Staging and treatment were determined for patients undergoing colorectal resections for adenocarcinomas in a single tertiary centre(2016–2020). Data were obtained for 948 patients. The staging was correct for both T and N stage in 19.68% of colon cancer patients. T stage was under-staged in 18.58%. At resection, 23 patients (3.36%) had involved pathological margins; only 7 of which had been predicted by pre-operative staging. However, the staging was correct for both T and N stage in 53.85% of rectal cancer patients. T stage was understaged in 26.89%. Thirteen patients had involved(R1)margins; T4 had been accurately predicted in all of these cases. There was a general trend in understaging both the tumor and lymphonodal involvement (T p < 0.00001 N p < 0.00001) causing a failure in administrating NT in 0.1% of patients with colon tumor, but not with rectal cancer. Preoperative radiological staging tended to understage both colonic and rectal cancers. In colonic tumours this may lead to a misled opportunity to treat with neoadjuvant therapy, resulting in involved margins at resection.
Fine cartels
Authors: Levine David K. 
Published: July 2021

AbstractThis paper studies a simple model of a repeated cartel that can punish using both voluntary fines and inefficient prices wars. The idea is to use the fines in response to noisy signals of bad behavior and back it up with threats of price wars in response to the easily observed failure to pay the voluntary fines. The model is shown to deliver the insights of modern repeated game theory in an empirically accurate and tractable form.
Obesity management: at the forefront against disease stigma and therapeutic inertia
Authors: Busetto Luca , Sbraccia Paolo , Vettor Roberto 
Published: July 2021

AbstractObesity is a complex chronic relapsing disease, resulting from the interaction between multiple environmental, genetic and epigenetic causes, and supported by changes in the neuroendocrine mechanisms regulating energy balance and body weight. Adipose tissue dysfunction contributes to obesity-related complications. However, the prevalent narrative about the causes and mechanisms of obesity remains a much more simplistic one, based on the false assumption that individuals can fully control their body weight through appropriate behavioural choices. According to this narrative, obesity is simply reversible “persuading” the patient to follow healthier and more virtuous individual behaviours (moral judgement). This persistent narrative forms the deep root of the stigmatisation of people with obesity at the individual level and creates a clear discrepancy on how obesity prevention and cure are designed in comparison with the case of other non-communicable chronic diseases (clinical stigma). The promotion of systemic preventive measures against obesity is not supported at a political and social level by the persistence of a narrative of obesity as the simple consequence of individual failures and lack of willpower. The simplistic narrative of obesity as a self-imposed condition with an easy way-out (“eat less and move more”) creates a clear discrepancy on how obesity is managed by health care systems in comparison with other NCDs. The over-estimation of the efficacy of therapeutic intervention solely based on patients education and lifestyle modification is responsible of therapeutic inertia in health care professionals and in clinical guidelines, limiting or delaying the adoption of more effective therapeutic strategies, like anti-obesity medications and bariatric surgery. In conclusion, the persistence of a narrative describing obesity as a self-induced easily reversible condition has profound consequences on how obesity prevention and management are build, including the design and implementation of obesity management guidelines and a tendency to therapeutic inertia.Level of evidence: No level of evidence.
MLaaS4HEP: Machine Learning as a Service for HEP
Authors: Kuznetsov Valentin , Giommi Luca , Bonacorsi Daniele 
Published: July 2021

AbstractMachine Learning (ML) will play a significant role in the success of the upcoming High-Luminosity LHC (HL-LHC) program at CERN. An unprecedented amount of data at the exascale will be collected by LHC experiments in the next decade, and this effort will require novel approaches to train and use ML models. In this paper, we discuss a Machine Learning as a Service pipeline for HEP (MLaaS4HEP) which provides three independent layers: a data streaming layer to read High-Energy Physics (HEP) data in their native ROOT data format; a data training layer to train ML models using distributed ROOT files; a data inference layer to serve predictions using pre-trained ML models via HTTP protocol. Such modular design opens up the possibility to train data at large scale by reading ROOT files from remote storage facilities, e.g., World-Wide LHC Computing Grid (WLCG) infrastructure, and feed the data to the user’s favorite ML framework. The inference layer implemented as TensorFlow as a Service (TFaaS) may provide an easy access to pre-trained ML models in existing infrastructure and applications inside or outside of the HEP domain. In particular, we demonstrate the usage of the MLaaS4HEP architecture for a physics use-case, namely, the $$t{\bar{t}}$$

t

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Higgs analysis in CMS originally performed using custom made Ntuples. We provide details on the training of the ML model using distributed ROOT files, discuss the performance of the MLaaS and TFaaS approaches for the selected physics analysis, and compare the results with traditional methods.
A Case Report of Large Bowel Obstruction in a Patient With an Inflatable Penile Prosthesis
Authors: Atri Elias , Mallory Chase , Perez Alejandra , Wong Vivian , Cordon Billy H. 
Published: July 2021

Abstract

Introduction
Inflatable penile prostheses (IPP) consist of 2 cylinders implanted into the corpora cavernosa, a pump placed in the scrotum, and a saline-filled reservoir traditionally placed in the space of Retzius. IPPs are used to treat refractory erectile dysfunction with few rare, but serious, complications. Cases of reservoirs causing erosion into the bladder, small bowel obstructions, vascular compression, and inguinal herniation have been described.

Aim
We highlight the importance of keeping a broad differential diagnosis when assessing patients with bowel obstructions.

Methods
A 68-year-old man with a previous IPP placement presented with left lower quadrant abdominal pain, constipation and obstipation for 5 days. On exam, he was afebrile, and noted to have a firm, distended, tympanic abdomen. CT scan showed a distended cecum at 11 cm, narrowing of the proximal sigmoid with adjacent inflammatory changes, and minimal peri-colonic air, suggestive of a localized perforation. The IPP reservoir was seen in the left iliac fossa, coinciding with the lead point of the obstruction, suggesting that the reservoir may have itself caused the obstruction. The patient was taken to the operating room for an emergent exploratory laparotomy, which revealed a mass in the colon abutting the IPP reservoir.

Main Outcome Measures
Considerations for IPP component explantation, factors considered for reintervention, and preservation of penile length with avoidance of penile fibrosis.

Results
A left colectomy with transverse colostomy was successfully performed and the IPP reservoir was explanted. Intraoperative frozen section revealed adenocarcinoma. Upon initial review of the imaging, it was thought that the IPP reservoir may have caused the obstruction, but intraoperatively, the colonic tumor was found to be the culprit.

Conclusion
Although complications related to IPPs, including bowel obstructions, have been previously described in the literature, treatment for large bowel obstructions must take into account all possible etiologies, including malignancy.
Atri E, Mallory C, Perez A, et al. A Case Report of Large Bowel Obstruction in a Patient With an Inflatable Penile Prosthesis. Sex Med 2021;9:100391.