bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyses of genetic diversity and population structure of anchote (Coccinia abyssinica (Lam.) Cogn.) using newly developed EST-SSR markers
Authors: Serbessa Tolera Bekele , Dagne Woldegebriel Kifle , Teshome Gari Abel , Geleta Dida Mulatu , Tesfaye Geletu Kassahun 
Published: February 2021

AbstractAnchote (Coccinia abyssinica (Lam.) Cogn.) is a perennial root crop belonging to Cucurbitaceae family. It is endemic to Ethiopia and distributed over wide range of agro-ecologies. For further improvement and efficient conservation of this crop, characterization of its genetic diversity and its pattern of distribution is a vitally important step. Expressed sequence tags-simple sequence repeats (EST-SSRs) markers were developed from publicly available watermelon [Citrullus lanatus (Thunb.) Matsum. & Nakai] ESTs in the GenBank database. Among those novel markers, eight were polymorphic and subsequently used for genetic diversity and population structure analyses of 30 anchote accessions collected from western Ethiopia. A total of 24 alleles were obtained across the eight polymorphic loci and 30 accessions that revealed moderate level of genetic diversity in this minor crop. Among the eight loci, locus CA_06 was the most informative with six alleles and polymorphic information content (PIC) of 0.76. The accessions showed about threefold variation in terms of genetic diversity, with expected heterozygosity (He) ranging from 0.15 (accession An) to 0.44 (accession Dg). Other accessions with higher genetic diversity include Ar and Gu (He = 0.43 and 0.41, respectively). Analysis of molecular variance (AMOVA) revealed that the variation within accessions and among accessions accounted for 84.7% and 15.3% of the total variation, respectively. The study revealed low but significant population differentiation in this crop with no clear pattern of population structure. The EST-SSR markers developed in this study are the first of their kind for anchote and can be used for characterization of its wider genetic resources for conservation and breeding purposes.
Autism Detection in Children by Combined Use of Gaze Preference and the M-CHAT-R in a Resource-Scarce Setting
Authors:   On behalf of the Autism Working Group in Peru, Jensen Kelly , Noazin Sassan , Bitterfeld Leandra , Carcelen Andrea , Vargas-Cuentas Natalia I. , Hidalgo Daniela , Valenzuela Alejandra , Roman-Gonzalez Avid , Krebs Casey , Clement Vincent , Nolan Cody , Barrientos Franklin , Mendoza Ardi Knobel , Noriega-Donis Paola , Palacios Claudia , Ramirez Andrea , Vittet Macarena , Hafeez Emil , Torres-Viso Mariana , Velarde Myriam , Moulton Lawrence H. , Powers Michael D. , Gilman Robert H. , Zimic Mirko 
Published: February 2021

AbstractMost children with autism spectrum disorder (ASD), in resource-limited settings (RLS), are diagnosed after the age of four. Our work confirmed and extended results of Pierce that eye tracking could discriminate between typically developing (TD) children and those with ASD. We demonstrated the initial 15 s was at least as discriminating as the entire video. We evaluated the GP-MCHAT-R, which combines the first 15 s of manually-coded gaze preference (GP) video with M-CHAT-R results on 73 TD children and 28 children with ASD, 36–99 months of age. The GP-MCHAT-R (AUC = 0.89 (95%CI: 0.82–0.95)), performed significantly better than the MCHAT-R (AUC = 0.78 (95%CI: 0.71–0.85)) and gaze preference (AUC = 0.76 (95%CI: 0.64–0.88)) alone. This tool may enable early screening for ASD in RLS.
Optimizing the control group for evaluating ART outcomes: can outpatient claims data yield a better control group?
Authors: Stern Judy E. , Liu Chia-Ling , Cui Xiaohui , Gopal Daksha , Cabral Howard J. , Coddington Charles C. , Missmer Stacey A. , Hwang Sunah S. , Farland Leslie V. , Dukhovny Dmitry , Diop Hafsatou 
Published: February 2021

Abstract
Purpose
We previously developed a subfertile comparison group with which to compare outcomes of assisted reproductive technology (ART) treatment. In this study, we evaluated whether insurance claims data in the Massachusetts All Payers Claims Database (APCD) defined a more appropriate comparison group.

Methods
We used Massachusetts vital records of women who delivered between 2013 and 2017 on whom APCD data were available. ART deliveries were those linked to a national ART database. Deliveries were subfertile if fertility treatment was marked on the birth certificate, had prior hospitalization with ICD code for infertility, or prior fertility treatment. An infertile group included women with an APCD outpatient or inpatient ICD 9/10 infertility code prior to delivery. Fertile deliveries were none of the above. Demographics, health risks, and obstetric outcomes were compared among groups. Multivariable generalized estimating equations were used to calculate adjusted relative risk (aRR) and 95% confidence intervals (CI).

Results
There were 70,726 fertile, 4,763 subfertile, 11,970 infertile, and 7,689 ART-treated deliveries. Only 3,297 deliveries were identified as both subfertile and infertile. Both subfertile and infertile were older, and had more education, chronic hypertension, and diabetes than the fertile group and less than the ART-treated group. Prematurity (aRR = 1.15–1.17) and birthweight (aRR = 1.10–1.21) were increased in all groups compared with the fertile group.

Conclusion
Although the APCD allowed identification of more women than the previously defined subfertile categorization and allowed us to remove previously unidentified infertile women from the fertile group, it is not clear that it offered a clinically significantly improved comparison group.
Influence of a bark-filler on the properties of PLA biocomposites
Authors: Borysiuk Piotr , Boruszewski Piotr , Auriga Radosław , Danecki Leszek , Auriga Alicja , Rybak Katarzyna , Nowacka Małgorzata 
Published: February 2021

AbstractIn this study, wood plastic composites (WPC) made of poly(lactic acid) PLA and a bark-filler were manufactured. Two degrees of bark comminution (10–35 mesh and over 35 mesh) and varied content of bark (40, 50 and 60%) were investigated. The studied panels were compared with analogically manufactured HDPE boards. The manufacture of composites involved two stages: at first, WPC granules with the appropriate formulation were produced using the extruder (temperatures in individual extruder sections were 170–180 °C) and crushing using a hammer mill after cooling the extruded composite; secondly, the obtained granulate was used to produce boards with nominal dimensions of 300 × 300 × 2.5 mm3 by flat pressing in a mold, using a single daylight press at a temperature 200 °C. The study proved that comminuted bark can be applied as a filler in PLA composites. However, an increase in bark content decreased mechanical properties (MOR, MOE) and deteriorated humidity resistance (high TS and WA) of the panels. Along with the increase in bark content, an increase in the contact angle of the composite surfaces and a decrease in the total surface energy were noted. It was also found that PLA composites have higher strength parameters and lower moisture resistance compared to HDPE composites with the same bark content.Graphical abstract
Anesthetics affect peripheral venous pressure waveforms and the cross-talk with arterial pressure
Authors: Al-Alawi Ali Z. , Henry Kaylee R. , Crimmins Lauren D. , Bonasso Patrick C. , Hayat Md Abul , Dassinger Melvin S. , Burford Jeffrey M. , Jensen Hanna K. , Sanford Joseph , Wu Jingxian , Sexton Kevin W. , Jensen Morten O. 
Published: February 2021

AbstractAnalysis of peripheral venous pressure (PVP) waveforms is a novel method of monitoring intravascular volume. Two pediatric cohorts were studied to test the effect of anesthetic agents on the PVP waveform and cross-talk between peripheral veins and arteries: (1) dehydration setting in a pyloromyotomy using the infused anesthetic propofol and (2) hemorrhage setting during elective surgery for craniosynostosis with the inhaled anesthetic isoflurane. PVP waveforms were collected from 39 patients that received propofol and 9 that received isoflurane. A multiple analysis of variance test determined if anesthetics influence the PVP waveform. A prediction system was built using k-nearest neighbor (k-NN) to distinguish between: (1) PVP waveforms with and without propofol and (2) different minimum alveolar concentration (MAC) groups of isoflurane. 52 porcine, 5 propofol, and 7 isoflurane subjects were used to determine the cross-talk between veins and arteries at the heart and respiratory rate frequency during: (a) during and after bleeding with constant anesthesia, (b) before and after propofol, and (c) at each MAC value. PVP waveforms are influenced by anesthetics, determined by MANOVA: p value < 0.01, η2 = 0.478 for hypovolemic, and η2 = 0.388 for euvolemic conditions. The k-NN prediction models had 82% and 77% accuracy for detecting propofol and MAC, respectively. The cross-talk relationship at each stage was: (a) ρ = 0.95, (b) ρ = 0.96, and (c) could not be evaluated using this cohort. Future research should consider anesthetic agents when analyzing PVP waveforms developing future clinical monitoring technology that uses PVP.
Love In-Between
Authors: Candiotto Laura , De Jaegher Hanne 
Published: February 2021

AbstractIn this paper, we introduce an enactive account of loving as participatory sense-making inspired by the “I love to you” of the feminist philosopher Luce Irigaray. Emancipating from the fusionist concept of romantic love, which understands love as unity, we conceptualise loving as an existential engagement in a dialectic of encounter, in continuous processes of becoming-in-relation. In these processes, desire acquires a certain prominence as the need to know (the other, the relation, oneself) more. We build on Irigaray’s account of love to present a phenomenology of loving interactions and then our enactive account. Finally, we draw some implications for ethics. These concern language, difference, vulnerability, desire, and self-transformation.
Conditional Consent
Authors: Chadha Karamvir 
Published: February 2021

AbstractThere are two distinct ways for someone to place conditions on their morally valid consent. The first is to place conditions on the moral scope of their consent—whereby they waive some moral claim rights but not others. The second is to conditionally token consent—whereby the condition affects whether they waive any moral claim rights at all. Understanding this distinction helps make progress with debates about so-called “conditional consent” to sexual intercourse in English law, and with understanding how individuals place conditions on their morally valid consent in other contexts.
Association of macrophage inhibitory factor -1 polymorphisms with antiviral efficacy of type 1b chronic hepatitis C
Authors: Ye Songdao , Chen Yao , Lou Xiaoting , Ye Xuanmei , Yang Xunjun 
Published: February 2021

AbstractThe expression of macrophage inhibitory factor-1 (MIC-1) increases in patients with chronic hepatitis C (CHC), but whether MIC-1 level and its polymorphism affect the antiviral efficacy of CHC has not yet been reported. The present study aimed to investigate the association between MIC-1 polymorphism and antiviral efficacy in patients with CHC genotype 1b (CHC 1b). A total of 171 patients with CHC1b were recruited. The polymorphisms of rs1059369 and rs1059519 inMIC-1were detected by DNA sequencing. All patients received a standard dose of polyethylene glycol interferon + ribavirin (PR regimen), and divided into response, nonresponse, sustained virological response (SVR), and non-sustained virological response (NSVR) groups based on HCV RNA levels. The genotype distribution of the two single nucleotide polymorphisms (SNPs) did not differ between the response and nonresponse groups, SVR and non-SVR groups. However, the level of MIC-1 was positively correlated with ALT, AST, PIIINP, CIV, andHCVRNA (P < 0.05). Compared to before treatment, the level of MIC-1 in plasma was significantly decrease in the response group but not in the non-responsive group. Our results suggest that the level of MIC-1 in CHC1b is correlated with liver cell injury, liver fibrosis index, and viral load. However, the polymorphism of rs1059369 and rs1059519 may have negligible impact in expression of MIC-1 and efficacy of antiviral therapy in CHC patient.
Ethics-Based Auditing to Develop Trustworthy AI
Authors: Mökander Jakob , Floridi Luciano 
Published: February 2021

AbstractA series of recent developments points towards auditing as a promising mechanism to bridge the gap between principles and practice in AI ethics. Building on ongoing discussions concerning ethics-based auditing, we offer three contributions. First, we argue that ethics-based auditing can improve the quality of decision making, increase user satisfaction, unlock growth potential, enable law-making, and relieve human suffering. Second, we highlight current best practices to support the design and implementation of ethics-based auditing: To be feasible and effective, ethics-based auditing should take the form of a continuous and constructive process, approach ethical alignment from a system perspective, and be aligned with public policies and incentives for ethically desirable behaviour. Third, we identify and discuss the constraints associated with ethics-based auditing. Only by understanding and accounting for these constraints can ethics-based auditing facilitate ethical alignment of AI, while enabling society to reap the full economic and social benefits of automation.
Active control of liquid film flows: beyond reduced-order models
Authors: Cimpeanu Radu , Gomes Susana N. , Papageorgiou Demetrios T. 
Published: February 2021

AbstractThe ability to robustly and efficiently control the dynamics of nonlinear systems lies at the heart of many current technological challenges, ranging from drug delivery systems to ensuring flight safety. Most such scenarios are too complex to tackle directly, and reduced-order modelling is used in order to create viable representations of the target systems. The simplified setting allows for the development of rigorous control theoretical approaches, but the propagation of their effects back up the hierarchy and into real-world systems remains a significant challenge. Using the canonical set-up of a liquid film falling down an inclined plane under the action of active feedback controls in the form of blowing and suction, we develop a multi-level modelling framework containing both analytical models and direct numerical simulations acting as an in silico experimental platform. Constructing strategies at the inexpensive lower levels in the hierarchy, we find that offline control transfer is not viable; however, analytically informed feedback strategies show excellent potential, even far beyond the anticipated range of applicability of the models. The detailed effects of the controls in terms of stability and treatment of nonlinearity are examined in detail in order to gain understanding of the information transfer inside the flows, which can aid transition towards other control-rich frameworks and applications.
PpGRAS12 acts as a positive regulator of meristem formation in Physcomitrium patens
Authors: Beheshti Hossein , Strotbek Christoph , Arif M. Asif , Klingl Andreas , Top Oguz , Frank Wolfgang 
Published: February 2021

Abstract
Key message
This study focused on the key regulatory function of Physcomitrium patens GRAS12 gene underlying an increasing plant complexity, an important step in plant terrestrialization and the evolutionary history of life.

Abstract
The miR171‐GRAS module has been identified as a key player in meristem maintenance in angiosperms. PpGRAS12 is a member of the GRAS family and a validated target for miR171 in Physcomitrium (Physcomitrella) patens. Here we show a regulatory function of miR171 at the gametophytic vegetative growth stage and targeted deletion of the PpGRAS12 gene adversely affects sporophyte production since fewer sporophytes were produced in ΔPpGRAS12 knockout lines compared to wild type moss. Furthermore, highly specific and distinct growth arrests were observed in inducible PpGRAS12 overexpression lines at the protonema stage. Prominent phenotypic aberrations including the formation of multiple apical meristems at the gametophytic vegetative stage in response to elevated PpGRAS12 transcript levels were discovered via scanning electron microscopy. The production of multiple buds in the PpGRAS12 overexpression lines similar to ΔPpCLV1a/1b disruption mutants is accompanied by an upregulation of PpCLE and downregulation of PpCLV1, PpAPB, PpNOG1, PpDEK1, PpRPK2 suggesting that PpGRAS12 acts upstream of these genes and negatively regulates the proposed pathway to specify simplex meristem formation. As CLV signaling pathway components are not present in the chlorophytic or charophytic algae and arose with the earliest land plants, we identified a key regulatory function of PpGRAS12 underlying an increasing plant complexity, an important step in plant terrestrialization and the evolutionary history of life.
Reducing HIV/STI Risk Among Adolescents Aged 12 to 14 Years: a Randomized Controlled Trial of Project Prepared
Authors: Bauman Laurie J. , Watnick Dana , Silver Ellen Johnson , Rivera Angelic , Sclafane Jamie Heather , Rodgers Caryn R. R. , Leu Cheng-Shiun 
Published: February 2021

AbstractDespite calls for evidence-based HIV/STI prevention programs for youth aged 12 to 14 transitioning to adolescence, few effective programs exist. In a two-group intent-to-treat randomized trial in the Bronx, NY, 397 participants were randomly assigned to Project Prepared or an attention control, TEEN. Participants completed surveys at baseline, 6 months, and 12 months. Prepared had two components, an 11-session program and a 3-week internship. Content covered sexual risk behavior, social cognitions, gender norms, relationships, and resilience. TEEN built communication skills and had the same intensity and structure as Prepared but no sexual content. In both, boys and girls were trained together in mixed groups of ~ 11 teens. Primary outcomes were HIV knowledge, self-efficacy, condom outcome expectancy, and behavioral intentions. Secondary outcomes were relationship expectations and endorsement of risky gender norms. Generalized estimating equation analyses showed youth randomized to Prepared had significant improvements compared to TEEN at T2 in HIV knowledge, sexual self-efficacy, and outcome expectancy for condom use. At T3, there were significant differences favoring Prepared in outcome expectancy for condom use, sexual self-efficacy, and intention for partner communication about HIV/AIDS or STIs. Analyses by gender showed program effects in both boys (intention to talk to a partner about condom use, abstinence self-efficacy, sexual self-efficacy, and condom outcome expectancy) and girls (gender norms, and abstinence outcome expectancy). Prepared effectively reduced risk in young adolescents. ClinicalTrials.gov ID: NCT01880450, Protocol ID: 2008-551
Identifying the minimal important difference in patient-reported outcome measures in the field of people with severe mental illness: a pre–post-analysis of the Illness Management and Recovery Programme
Authors: Beentjes Titus A. A. , Teerenstra Steven , Vermeulen Hester , Goossens Peter J. J. , der Sanden Maria W. G. Nijhuis-van , van Gaal Betsie G. I. 
Published: February 2021

Abstract
Purpose
Complementary interventions for persons with severe mental illness (SMI) focus on both personal recovery and illness self-management. This paper aimed to identify the patient-reported outcome measures (PROMs) associated with the most relevant and meaningful change in persons with SMI who attended the Illness Management and Recovery Programme (IMR).

Methods
The effect of the IMR was measured with PROMs concerning recovery, illness self-management, burden of symptoms and quality of life (QoL). From the QoL measures, an anchor was chosen based on the most statistically significant correlations with the PROMs. Then, we estimated the minimal important difference (MID) for all PROMs using an anchor-based method supported by distribution-based methods. The PROM with the highest outcome for effect score divided by MID (the effect/MID index) was considered to be a measure of the most relevant and meaningful change.

Results
All PROMs showed significant pre–post-effects. The QoL measure ‘General Health Perception (Rand-GHP)’ was identified as the anchor. Based on the anchor method, the Mental Health Recovery Measure (MHRM) showed the highest effect/MID index, which was supported by the distribution-based methods. Because of the modifying gender covariate, we stratified the MID calculations. In most MIDs, the MHRM showed the highest effect/MID indexes.

Conclusion
Taking into account the low sample size and the gender covariate, we conclude that the MHRM was capable of showing the most relevant and meaningful change as a result of the IMR in persons with SMI.
To be Mother or not? Cultural Models of Motherhood and Their Meaning Effects on Gendered Representations
Authors: Turco Federica 
Published: February 2021

AbstractIn this paper I will focus on the concept of the person in its philosophical, representative and bodily facets, in a gender perspective. Starting from the interesting figure of Gianna Beretta Molla, known for having been beatified for having sacrificed her own life to save that of the child she was carrying, I’ll try to reason about some key concepts concerning women representation in modernity, such as motherhood, iconic figures and cultural models from which the meaning of feminine subjects itself depends.
Measuring Non-electoral Political Participation: Bi-factor Model as a Tool to Extract Dimensions
Authors: Koc Piotr 
Published: February 2021

AbstractPolitical participation is a mainstay of political behavior research. One of the main dilemmas many researchers face pertains to the number of dimensions of political participation, i.e. whether we should model political participation as a unidimensional or multidimensional latent construct. Over the years, scholars usually have favored the solution with more than one dimension of political participation and they have backed the claim of multiple dimensions with a number of empirical tests. In this paper, I argue that the results from the frequently used testing procedures which rely on the model fit inspection and the Kaiser criterion can be very misleading and may yield in extracting too many dimensions. By employing bi-factor modeling to a European Social Survey dataset, I show that in a majority of countries political participation can be considered an essentially unidimensional latent quantity. I demonstrate that additional dimensions of political participation are very weak and unreliable and that we cannot regress them on external variables nor build composite scores based on them. These findings cast doubt on the conclusions of numerous previous studies where researchers modeled more than one dimension of political participation.
A wavelet-based approach for imputation in nonstationary multivariate time series
Authors: Wilson Rebecca E. , Eckley Idris A. , Nunes Matthew A. , Park Timothy 
Published: February 2021

AbstractMany multivariate time series observed in practice are second order nonstationary, i.e. their covariance properties vary over time. In addition, missing observations in such data are encountered in many applications of interest, due to recording failures or sensor dropout, hindering successful analysis. This article introduces a novel method for data imputation in multivariate nonstationary time series, based on the so-called locally stationary wavelet modelling paradigm. Our methodology is shown to perform well across a range of simulation scenarios, with a variety of missingness structures, as well as being competitive in the stationary time series setting. We also demonstrate our technique on data arising in a health monitoring application.