bluuebunny/crossref_metadata_2025_split huggingface dataset:
Porous composite coatings for implants
Authors:   Lomonosov Moscow State University, Geological faculty, Sokolov V. N. , Razgulina O. V. ,   Lomonosov Moscow State University, Geological faculty, Chernov M. S. ,   Lomonosov Moscow State University, Geological faculty, Mamaeva V. A. ,   Institute of Strength Physics and Materials Science, Siberian Branch of the RAS, Mamaev A. I. ,   Institute of Strength Physics and Materials Science, Siberian Branch of the RAS, Kalita V.I. ,   Baikov Institute of metallurgy and materials science of the Russian Academy of Sciences, Komlev D. I. ,   Baikov Institute of metallurgy and materials science of the Russian Academy of Sciences, Radyuk A. A. ,   Baikov Institute of metallurgy and materials science of the Russian Academy of Sciences
Published: August 2021

An analysis of the surface of a plasma three-dimensional capillary-porous (TCP) Ti coating with an additional bioactive hydroxyapatite coating formed by microplasma oxidation (MPO) has been performed. Scanning electron microscopy (SEM) analyzed the open porosity of these composite coatings. The surface of the TCP Ti coating consists of ridges and depressions. The porosity of the TCP Ti coating of the depressions reaches 43 %. The presence of macro- and micropores with a size of 0.08 – 600 µm makes the TCP Ti coatings promising for use in a number of areas, including on the surface of intraosseous implants.
Solvatochromic effects in absorption and luminescence spectra and stability of emission quantum yield of carbon nanoparticles (part I)
Authors:   Lebedev Physical Institute of Russian Academy of Science, Kazaryan S. A. , Nevolin V. N. ,   Lebedev Physical Institute of Russian Academy of Science, Pilosyan S. Kh. ,   Lebedev Physical Institute of Russian Academy of Science
Published: August 2021

The features of the solvatochromic effects of absorption (Ab) and photoluminescence (PL) spectra, as well as the quantum yield of emission (QYE) of carbon nanoparticles (CNPs) synthesized by various methods from a mixture of citric acid and nitrogen-containing precursors, in protic and aprotic solvents have been studied. It has been shown that the parameters of the spectra Ab, PL and the QYE value of particle solutions to a large extent depend on the method, conditions and modes of synthesis, the method of modification and separation of CNPs, the types and composition of precursors, and also the fundamental properties and pH of solvents. In solvents with a dielectric constant of 4.5 – 109.5, the QYE value of particles varies in a wide range from 10.8 to 100.0 %, and the PL band peak shifts from 466.4 to 536.8 nm. The presence of strong solvatochromic effects in the spectra of Ab and PL particles was shown, and the important role of the processes of protonation and deprotonation of surface groups of CNPs was established. The influence of universal and specific interactions on the spectroscopic parameters of CNPs has been investigated, and a significant contribution to the solvatochromic effects of specific interactions has been demonstrated.
Prevalence and Etiology of Neonatal Jaundice in a Tertiary Care Hospital
Authors: Acharya Niraj , Paneru Chandra Prasad 
Published: August 2021

Introduction: Neonatal jaundice is a major clinical condition worldwide occurring in upto 60% of term and 80% preterm newborn in the first week of life. Neonatal jaundice is defined as total serum bilirubin level above 7 mg/dl.
Aims: This study was done to find out the prevalence and etiology of neonatal jaundice in neonates admitted to Neonatal Intensive Care Unit (NICU) of Nepalgunj Medical College Teaching Hospital (NGMCTH) Kohalpur, Banke.
Methods: It was a prospective cross sectional hospital based study conducted from November 2018 to November 2019 in Neonatal Intensive Care Unit of Nepalgunj Medical College Teaching Hospital. All neonates with clinical jaundice and hyperbilirubinemia with total serum bilirubin of ≥7 mg/dl were subjected to complete history taking, through physical examination and investigations.
Results: Out of 892 neonates who developed clinical jaundice, 640 neonates whose parents gave consent were included in the study. The prevalence of neonatal jaundice was found to be 39.85% with male to female ratio of 1.79:1. In the present study pathological jaundice was seen in 74.94% whereas physiological jaundice in 23.66%. Among the various etiologies of pathological jaundice, neonatal sepsis (44.52%) was found to be the most common cause followed by ABO incompatibility (12.18%) and Rh incompatibility (7.03%).
Conclusion: The prevalence of neonatal jaundice in present study was 39.85% and the most common cause was neonatal sepsis .The prevalence of jaundice was more in preterm than in term neonates. Neonatal jaundice is very common morbidity in NICU especially in preterm babies.
Extracranial arteriovenous malformation and subsequent contralateral cavernous sinus dural arteriovenous fistula showing abducens nerve palsy: illustrative case
Authors: Tsukada Atsushi , Yanaka Kiyoyuki , Nakamura Kazuhiro , Takahashi Nobuyuki , Onuma Kuniyuki , Takada Maya , Sato Masayuki , Matsumaru Yuji , Ishikawa Eiichi 
Published: August 2021

BACKGROUND
Extracranial arteriovenous malformations (AVMs) are rare clinical entities and on rare occasions cause neurological symptoms. The authors report a case of an extracranial pterygoid AVM and a subsequent contralateral cavernous sinus dural arteriovenous fistula (dAVF) presenting with abducens nerve palsy.

OBSERVATIONS
An 80-year-old woman was referred to the authors’ hospital with left abducens nerve palsy followed by right ophthalmalgia. Magnetic resonance imaging (MRI) showed abnormal vessel staining in the left pterygoid and the right inferior petrosal sinus (IPS). Cerebral angiography revealed a left pterygoid AVM draining into the right IPS via the cavernous sinus (CS). A dAVF in the right CS was also revealed. The right ophthalmalgia disappeared spontaneously, and, 4 months later, the left abducens nerve palsy also disappeared after conservative management. Follow-up MRI showed spontaneous regression of the AVM and dAVF. The disappearance of the dAVF was considered to be due to spontaneous regression of the left pterygoid AVM and the consequent decrease in venous pressure of the CS, and the symptoms eventually disappeared.

LESSONS
The authors treated an extremely rare case of extracranial AVM with dramatic changes in vascular structure and symptoms. Understanding of the pathophysiology between symptoms and dynamic changes in the vascular structure is essential for providing the appropriate treatment.
Pengaruh Pembelajaran Daring terhadap Peningkatan Nilai Siswa Kelas X di SMK Ma’arif 9 Kebumen
Authors: Mufid Rozikin  , Sari Sulimei , Suratno  , Nurhayati Soviyana 
Published: August 2021

Covid-19 memiliki dampak yang cukup signifikan dalam kehidupan masyarakat pada saat ini, salah satunya dalam bidang pendidikan. Pembelajaran yang seharusnya dilakukan secara tatap muka harus ditiadakan dan digantikan dengan pembelajaran daring. Saat ini pembelajaran daring menjadi sarana alternatif bagi tenaga pendidik agar kegiatan belajar mengajar tetap berjalan meskipun siswa sedang berada di rumah.
Pembelajaran daring memiliki sisi positif dan sisi negatif, bagi siswa dampak negatifnya yaitu siswa kurang optimal dalam menguasai materi yang disampaikan guru sehingga membuat nilai para siswa menjadi turun. Penelitian ini bertujuan untuk mengetahui nilai rata - rata kelas X sebelum pandemi Covid-19 dan sesudah pandemi Covid-19 di SMK Ma’arif 9 Kebumen, serta untuk mengetahui kendala apa saja yang diraskan guru maupun siswa dalam melaksanakan pembelajaran daring selama masa pandemi Covid-19. Metode yang digunakan dalam penelitian ini adalah penelitian deskrtiptif dengan pendekatan kualitatif. Penelitian ini telah dilakukan pada tanggal 25 Januari sampai 2 Maret 2021 Tahun Ajaran 2020/2021 di SMK Ma’arif 9 Kebumen. Sampel penelitian ini terdiri dari satu kelas. Penentuan sample dengan menggunakan teknik sampling purposive. Hasil penelitian menunjukan bahwa dalam pembelajaran daring di SMK Maarif 9 Kebumen Nilai Rata-rata sebelum pandemi 86,92 dan sesudah pandemi 84,38,sehingga terjadi selisih penurunan nilai sebesar 2,54. Sehingga dapat disimpulkan bahwa dalam pembelajaran daring mempengaruhi penurunan nilai rata-rata kelas sebesar 3,01% jika dibandingkan dengan nilai sebelum pandemi.
Designing LQR Controllers for an Active Anti-roll Bar System with a Flexible Frame Model of a Single Unit Heavy Vehicle
Authors: Vu Van Tan , Tran Van Da , Pham Quoc Trung , Truong Manh Hung , Sename Oliver , Gaspar Peter 
Published: August 2021

Rollover accidents of heavy vehicles often cause serious consequences both in terms of vehicle and environmental damage as well the loss or injury of drivers, passengers and ordinary civilians. Currently, the active anti-roll bar system is considered as the most effective solution in enhancing vehicle roll stability. In this paper, we firstly investigated the role of a flexible frame of a single unit heavy vehicle in the rollover process. This approach is an important step forward in the research of the active anti-roll bar system. Then, the LQR control method is applied in designing controllers for the active anti-roll bar control system with this frame model. The active torque of the anti-roll bar system is considered as the control signal. The simulation results in the frequency and time domains with a double lane change maneuver show that the vehicle’s roll stability is improved by over 30 % compared to a vehicle using a passive anti-roll bar system.
Postcardiotomy Veno-Arterial Extracorporeal Membrane Oxygenation: Does the Cannulation Technique Influence the Outcome?
Authors: Kalampokas Nikolaos , Sipahi Nihat Firat , Aubin Hug , Akhyari Payam , Petrov Georgi , Albert Alexander , Westenfeld Ralf , Lichtenberg Artur , Saeed Diyar 
Published: August 2021

Objectives: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) may be cannulated using either central (cannulation of aorta) or peripheral (cannulation of femoral or axillary artery) access. The ideal cannulation approach for postcardiotomy cardiogenic shock (PCS) is still unknown. The aim of this study is to compare the outcome of patients with PCS who were supported with central vs. peripheral cannulation.Methods: This is a single-center retrospective data analysis including all VA-ECMO implantations for PCS from January 2011 to December 2017. The central and peripheral approaches were compared in terms of patient characteristics, intensive care unit (ICU) stay, hospitalization length, adverse event rates, and overall survival.Results: Eighty-six patients met the inclusion criteria. Twenty-eight patients (33%) were cannulated using the central approach, and 58 patients (67%) were cannulated using the peripheral approach. Forty-three patients (50%) received VA-ECMO in the operating room and 43 patients (50%) received VA-ECMO in the ICU. Central VA-ECMO group had higher EuroSCORE II (p = 0.007), longer cross-clamp time (p = 0.054), higher rate of open chest after the procedure (p &lt; 0.001), and higher mortality rate (p = 0.02). After propensity score matching, 20 patients in each group were reanalyzed. In the matched groups, no statistically significant differences were observed in the baseline characteristics between the two groups except for a higher rate of open chests in the central ECMO group (p = 0.02). However, no significant differences were observed in the outcome and complications between the groups.Conclusions: This study showed that in postcardiotomy patients requiring VA-ECMO support, similar complication rates and outcome were observed regardless of the cannulation strategy.
A New Vision at the Interface of Atrial Fibrillation and Stroke
Authors: Ronsoni Rafael M. , Saffi Marco Aurélio Lumertz , Gonçalves Marcus Vinicius Magno , Nakayama Igor Hidetsu , Luz Leiria Tiago Luiz 
Published: August 2021

Introduction: Current evidence questions the linear sequence traditionally described in atrial fibrillation, blood stasis, intracavitary thrombus, and embolization to the central nervous system. Currently, new perspectives have been described based on questions from the linearly traditional chronology of events; it is within this scope that the article has its objective.Evidences: The association of the two entities is biologically plausible and supported by different cohorts with a higher risk of developing atrial fibrillation, especially in the cardioembolic form. Concepts (temporal dissociation, biological gradient, etc.) determine the existence of other factors associated with cardioembolism, not exclusively by atrial fibrillation. The entire cascade of events associated with myopathy and atrial remodeling can generate damage to the myocyte and amplify the prothrombotic status. It is important to clarify that atrial myopathy can present itself as atrial fibrillation initially or not, but should always be considered thrombogenic in all the contexts of their clinical presentation. Considering atrial heart disease as a cause of embolic stroke, it could explain that one-third of strokes are considered cryptogenic.Conclusions: The traditional model exclusively associating the presence of atrial fibrillation in the genesis of thromboembolism is incomplete. The concept of atrial cardiopathy where cardioembolism occurs in a non-atrial fibrillation dependent manner fits better with current data. The future challenge is to effectively detect the various manifestations of atrial heart disease, generating direct implications for the identification of patients at risk of stroke and also for better management after a cardioembolic event.
Pulsed Field Ablation of Superior Vena Cava: Feasibility and Safety of Pulsed Field Ablation
Authors: Zhu Tongjian , Wang Zhen , Wang Songyun , Shi Tiancai , Zhu Xiaolin , Ma Kezhong , Wang Zhuo , Gao Jinnian , Jiang Hong 
Published: August 2021

Background: Studies have shown that pulsed field ablation (PFA) has excellent effectiveness and safety in pulmonary vein isolation (PVI). However, there are few reports about the application of PFA, especially the alternating current (AC) biphase PFA, in superior vena cava (SVC) isolation, and its effectiveness and safety are still unclear.Objective: To investigate the efficacy and safety of the AC biphase PFA for SVC isolation, and to provide evidence for the clinical use of PFA for SVC.Methods: Eight pigs and two dogs were included in the study. PFA was delivered to these pigs and dogs. Pacing threshold and electrogram data were recorded before and after PFA. Voltage mapping of SCV was obtained before, after, and 3 weeks after PFA. At the end, all animals were euthanatized for gross pathology analysis.Results: For eight pigs, the median pacing threshold was 1.5 (1.4, 2.75) mA before PFA, while &gt; 6.0 mA after PFA for all animals. The average electrogram amplitude reduction was 61.33 ± 24.90% for ablations with the initial amplitude≥0.5 mv. For two dogs, pacing threshold change and electrogram amplitude reduction were also observed. No phrenic palsy or sinus node injury was observed during PFA in any animal. Furthermore, voltage mapping showed that the voltage amplitude was significantly decreased in all animals and this could be kept for more than 3 weeks. Moreover, transmural tissue damage with reserved vessel and nerve were shown, no SVC stenosis was found at 3 weeks after PFA.Conclusion: PFA can effectively isolate SVC. Transmural tissue damage of SVC can be achieved without phrenic palsy, sinus node injury nor SVC stenosis.
Anti–PD-1 and Anti–PD-L1 in Head and Neck Cancer: A Network Meta-Analysis
Authors: Botticelli Andrea , Cirillo Alessio , Strigari Lidia , Valentini Filippo , Cerbelli Bruna , Scagnoli Simone , Cerbelli Edoardo , Zizzari Ilaria Grazia , Rocca Carlo Della , D’Amati Giulia , Polimeni Antonella , Nuti Marianna , Merlano Marco Carlo , Mezi Silvia , Marchetti Paolo 
Published: August 2021

ObjectiveThe monoclonal antibodies anti-programmed death protein-1 (anti–PD-1) nivolumab and pembrolizumab are the first immune checkpoint inhibitors (ICIs) approved for treatment of recurrent/metastatic head and neck carcinoma R/M HNSCC in first line and in platinum refractory disease. This network meta-analysis aims to investigate the efficacy of anti–PD-1- vs anti–PD-L1-based therapy in R/M HNSCC cancer patients through a systematic review of the literature to provide support for evidence-based treatment decisions. In particular, the effectiveness of ICIs for R/M HNSCC is analyzed according to the different mechanisms of action of the check-points inhibitory drugs in different subgroups of patients.MethodsWe did a systematic literature review and network meta-analysis (NMA) of randomized controlled trials (RCTs) in PubMed, ClinicalTrials.gov, Embase, Medline, the Cochrane Central Register of Controlled Trials, Web of Science. Our search identified a total of five randomized controlled trials: Keynote 040, Keynote 048, Eagle, Condor, Checkmate 141. These trials included 3001 patients. Treatment was sub-categorized into PD-L1–based, PD-1–based, and standard chemotherapy. Treatments were indirectly compared with anti–PD-L1-based therapy.ResultsThe network meta-analysis demonstrated no significant differences in OS between different subgroups except for the metastatic patients in which anti–PD-1-based therapy was associated with significantly less risk of death. Furthermore, anti–PD-1-based therapy appeared to be effective in smoker patients and in human papilloma–negative (HPV) patients. Conversely, anti–PD-L1-based therapy seems to be better efficient in female patients, in locally recurrent setting and in HPV positive patients.ConclusionThis is the first NMA study that aimed to indirectly compare anti–PD-1- and anti–PD-L1-based therapy in HNSCC patients. The results of our NMA could help define a profile of patient responder or resistant to specific classes of immune drugs and can be used to guide/design future studies in the novel scenario of precision immune-oncology.
LIPAD (LRRK2/Luebeck International Parkinson's Disease) Study Protocol: Deep Phenotyping of an International Genetic Cohort
Authors: Usnich Tatiana , Vollstedt Eva-Juliane , Schell Nathalie , Skrahina Volha , Bogdanovic Xenia , Gaber Hanaa , Förster Toni M. , Heuer Andreas , Koleva-Alazeh Natalia , Csoti Ilona , Basak Ayse Nazli , Ertan Sibel , Genc Gencer , Bauer Peter , Lohmann Katja , Grünewald Anne , Schymanski Emma L. , Trinh Joanne , Schaake Susen , Berg Daniela , Gruber Doreen , Isaacson Stuart H. , Kühn Andrea A. , Mollenhauer Brit , Pedrosa David J. , Reetz Kathrin , Sammler Esther M. , Valente Enza Maria , Valzania Franco , Volkmann Jens , Zittel Simone , Brüggemann Norbert , Kasten Meike , Rolfs Arndt , Klein Christine ,   The LIPAD Study Group
Published: August 2021

Background: Pathogenic variants in the Leucine-rich repeat kinase 2 (LRRK2) gene are the most common known monogenic cause of Parkinson's disease (PD). LRRK2-linked PD is clinically indistinguishable from idiopathic PD and inherited in an autosomal dominant fashion with reduced penetrance and variable expressivity that differ across ethnicities and geographic regions.Objective: To systematically assess clinical signs and symptoms including non-motor features, comorbidities, medication and environmental factors in PD patients, unaffected LRRK2 pathogenic variant carriers, and controls. A further focus is to enable the investigation of modifiers of penetrance and expressivity of LRRK2 pathogenic variants using genetic and environmental data.Methods: Eligible participants are invited for a personal or online examination which comprises completion of a detailed eCRF and collection of blood samples (to obtain DNA, RNA, serum/plasma, immune cells), urine as well as household dust. We plan to enroll 1,000 participants internationally: 300 with LRRK2-linked PD, 200 with LRRK2 pathogenic variants but without PD, 100 PD patients with pathogenic variants in the GBA or PRKN genes, 200 patients with idiopathic PD, and 200 healthy persons without pathogenic variants.Results: The eCRF consists of an investigator-rated (1 h) and a self-rated (1.5 h) part. The first part includes the Movement Disorder Society Unified Parkinson's Disease Rating, Hoehn &amp;Yahr, and Schwab &amp; England Scales, the Brief Smell Identification Test, and Montreal Cognitive Assessment. The self-rating part consists of a PD risk factor, food frequency, autonomic dysfunction, and quality of life questionnaires, the Pittsburgh Sleep Quality Inventory, and the Epworth Sleepiness as well as the Hospital Anxiety and Depression Scales. The first 15 centers have been initiated and the first 150 participants enrolled (as of March 25th, 2021).Conclusions: LIPAD is a large-scale international scientific effort focusing on deep phenotyping of LRRK2-linked PD and healthy pathogenic variant carriers, including the comparison with additional relatively frequent genetic forms of PD, with a future perspective to identify genetic and environmental modifiers of penetrance and expressivityClinical Trial Registration:ClinicalTrials.gov, NCT04214509.
Could Camrelizumab Plus Chemotherapy Improve Clinical Outcomes in Advanced Malignancy? A Systematic Review and Network Meta-Analysis
Authors: Yang Chao , Xu Chang , Li Xiang , Zhang Yaowen , Zhang Simeng , Zhang Tongyu , Zhang Yingshi 
Published: August 2021

PurposeCamrelizumab is a novel programmed cell death 1 (PD-1) inhibitor. To determine the efficacy and safety of the combination treatment of camrelizumab+chemotherapy and camrelizumab monotherapy, and determine which is the most suitable malignancy type to be treated with camrelizumab, we performed a systematic review and network meta-analysis.MethodsWe searched PubMed, Embase, and the Cochrane Library for published clinical trials from database inception until April 2021. Studies that compared camrelizumab+chemotherapy and camrelizumab monotherapy in patients with advanced malignancy were included. We estimated odds ratios (ORs) with credible intervals (CIs) using network meta-analysis with random effects.ResultsWe included four clinical trials with 946 advanced malignancy patients. In terms of the efficacy evaluation of the objective response rate and progression-free survival, camrelizumab treatment for Hodgkin lymphoma (HL), camrelizumab treatment for esophageal squamous cell carcinoma (OSCC), and camrelizumab+chemo treatment for HL always ranked first. In terms of safety evaluation from leukocytopenia, hypothyroidism, and asthenia, camrelizumab treatment for OSCC and chemo always ranked first. This study was registered with PROSPERO, number CRD42021249193.ConclusionsPatients with advanced OSCC should be treated with camrelizumab. Patients with severely relapsed/refractory HL could use camrelizuma+chemo for combination treatment when they can tolerate adverse reactions.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=249193, PROSPERO (identifier, CRD42021249193).