bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why Seeing Should Not Always Be Believing
Authors: Zarmsky Sarah 
Published: June 2021

Abstract
Digital reconstructions of crime scenes have been used more frequently in both domestic and international courts as technology becomes more developed and accessible to courtroom actors. Though digital reconstructions can be beneficial, especially in the context of international criminal law, as they allow judges to visit crime scenes which would otherwise be too expensive or dangerous to travel to in person, there are inherent risks which come with the use of this novel type of evidence in a court of law. This article explores some key considerations which arise if digital reconstructions are to be used in international criminal courts and tribunals, with an emphasis on the rights of the accused and effects on victims and witnesses. It argues that in order for fair trial standards to be upheld and for international courts to fulfil their roles not just as prosecutors of crimes, but as seekers of truth and reconciliation, digital reconstructions need to be approached with caution and analysed through a critical eye.
Fructooligosaccharides production by immobilized Pichia pastoris cells expressing Schedonorus arundinaceus sucrose:sucrose 1-fructosyltransferase
Authors: Pérez Enrique R , Martínez Duniesky , Menéndez Carmen , Alfonso Dubiel , Rodríguez Iván , Trujillo Luis E , Sobrino Alina , Ramírez Ricardo , Pimentel Eulogio , Hernández Lázaro 
Published: June 2021

Abstract
Fructooligosaccharides (FOSs)—fructose-based oligosaccharides—are typical prebiotics with health-promoting effects in humans and animals. The trisaccharide 1-kestotriose is the most attractive inulin-type FOS. We previously reported a recombinant sucrose:sucrose 1-fructosyltransferase (1-SST, EC 2.4.1.99) from Schedonorus arundinaceus (Sa) that efficiently converts sucrose into 1-kestotriose. In this study, Pichia pastoris PGFT6x-308 constitutively expressing nine copies of the Sa1-SST gene displayed fructosyltransferase activity in undisrupted biomass (49.8 U/ml) and culture supernatant (120.7 U/ml) in fed-batch fermentation (72 hr) with sugarcane molasses. Toluene permeabilization increased 2.3-fold the Sa1-SSTrec activity of whole cells entrapped in calcium-alginate beads. The reaction with refined or raw sugar (600 g/l) yielded 1-kestotriose and 1,1-kestotetraose in a ratio of 8:2 with their sum representing above 55% (wt/wt) of total carbohydrates. The FOSs yield decreased to 45% (wt/wt) when sugarcane syrup and molasses were used as cheaper sucrose sources. The beads retained 80% residual Sa1-SSTrec activity after a 30-day batchwise operation with refined cane sugar at 30°C and pH 5.5. The immobilized biocatalyst is attractive for the continuous production of short-chain FOSs, most particularly 1-kestotriose.
Herbivores alleviate the negative effects of extreme drought on plant community by enhancing dominant species
Authors: Xu Chong , Ke Yuguang , Wu Honghui , Smith Melinda D , Lemoine Nathan P , Zhang Weiguo , Yu Qiang 
Published: June 2021

Abstract

Aims
Both extreme drought and insect herbivores can suppress plant growth in grassland communities. However, most studies have examined extreme drought and insects in isolation, and there is reason to believe that insects might alter the ability of grasslands to withstand drought. Unfortunately, few studies have tested the interactive effects of extreme drought and insect herbivores in grassland communities.

Methods
Here, we tested the drought–herbivore interactions using a manipulative experiment that factorially crossed extreme drought with the exclusion of insect herbivores in a temperate semiarid grassland in Inner Mongolia.

Important Findings
Our results demonstrated that both extreme drought and insect herbivores separately decreased total plant cover. When combined, insect herbivores reduced the impact of drought on total cover by increasing the relative abundance of drought-resistant dominant species. Our results highlight that the negative effect of extreme drought on total plant cover could be alleviated by maintaining robust insect herbivore communities.
Effects of soil nitrogen levels on growth and defense of the native and introduced genotypes of alligator weed
Authors: Liu Mu , Zhou Fang , Pan Xiaoyun , Zhang Zhijie , Li Bo 
Published: June 2021

AbstractPlants growing in nutrient-rich environment are predicted to be less defended than conspecifics under nutrient limitation. However, less is known about the effects of nutrient levels on tolerance and induced resistance, and whether the effects differ between native and introduced populations of invasive plants. We performed a greenhouse experiment with introduced (the USA) and native (Argentina) genotypes of Alternanthera philoxeroides in order to study the effects of soil nitrogen levels on plant growth, constitutive and herbivore (Agasicles hygrophila)-induced chemical defense, and herbivory tolerance. We measured total biomass, elongation rate (as proxy of growth rate), carbon and nitrogen, and the concentration of triterpenoid saponins (defensive chemicals) in leaves and roots. Constitutive resistance (+33% higher leaf triterpenoid saponins in control treatment at low nitrogen level) and tolerance [less decreased total biomass after herbivory treatment (−24% and −15% for high and low nitrogen levels)] were favored at lower nitrogen level, while induced resistance was favored at higher nitrogen level (+24% increased leaf triterpenoid saponins after herbivory treatment at high nitrogen level). Constitutive resistance and tolerance exhibited trade-offs with growth rate, while induced resistance positively correlated with growth rate. Additionally, the introduced genotypes had −6% lower content of leaf carbon in the presence of herbivores than the native genotypes at low nitrogen level, but such difference was absent at high nitrogen level. Our results indicate that soil nitrogen levels influence the preference of different defensive strategies of plant, and interweave with herbivory to determine the performance of introduced genotypes.
Impact of pharmacist-led services on antimicrobial stewardship programs: a meta-analysis on clinical outcomes
Authors: Mahmood Rana Kamran , Gillani Syed Wasif , Saeed Muhammad Waqas , Vippadapu Prasanna , Alzaabi Maryam Jaber Mohamed Abdulla 
Published: June 2021

Abstract

Purpose
This meta-analysis aims to find out the impact of pharmacists on clinical outcomes of antimicrobial stewardship (AMS).

Method
Articles were searched and analyzed based on quality assessed through the JSM quality assessment tool to filter articles with a low level of bias. Two thousand three hundred sixty articles were reviewed for initial screening and 28 articles were included for critical analysis. Statistical analysis used to risk ratio (RR) and standard mean differences calculated using Review manager 5.4. Confidence intervals (CI 95%) were calculated using the fixed-effect model. The I2 statistic assessed heterogeneity. A random-effect model performed in the case of statistical heterogeneity, subgroup and sensitivity analyses. The primary outcome is mortality and inappropriateness, whereas the secondary outcome is cost, readmission, length of stay, consumption and duration of therapy.

Result
A detailed review and analysis of 28 AMSs programs led by pharmacists showed low inappropriateness with pharmacist versus without pharmacist RR = 0.36 with 95% CI of (0.32 to 0.39) and mortality RR is 0.68 with 95% CI of 0.59 to 0.79. Secondary outcomes such as consumption, length of stay, duration of therapy and cost are standard mean difference of −1.61 with 95% CI (−1.72 to −1.50), −0.58 with 95% CI (−0.62 to −0.53), −0.95 with 95% CI (−1.01 to −0.89) and −0.99 with 95% CI (−1.12 to −0.86), respectively, whereas for 30 days readmission is RR = 0.81 with 95% CI (0.70 to 0.93).

Conclusion
AMS with pharmacist effectively reduces mortality, inappropriateness, cost, length of stay, duration of treatment, consumption of antimicrobials and the return rate to hospital. So it is suggested pharmacists should lead or play a vital role in antimicrobial stewardship programs to get better outcomes.
Survey of X-ray induced Cherenkov excited fluorophores with potential for human use
Authors: Pétusseau Arthur F , Bruza Petr , Pogue Brian W 
Published: June 2021

Abstract
X-ray induced molecular luminescence (XML) is a phenomenon that can be utilized for clinical, deep-tissue functional imaging of tailored molecular probes. In this study, a survey of common or clinically approved fluorophores was carried out for their megavoltage X-ray induced excitation and emission characteristics. We find that direct scintillation effects and Cherenkov generation are two possible ways to cause these molecules’ excitation. To distinguish the contributions of each excitation mechanism, we exploited the dependency of Cherenkov radiation yield on X-ray energy. The probes were irradiated by constant dose of 6 MV and 18 MV X-ray radiation, and their relative emission intensities and spectra were quantified for each X-ray energy pair. From the ratios of XML, yield for 6 MV and 18 MV irradiation we found that the Cherenkov radiation dominated as an excitation mechanism, except for aluminum phthalocyanine, which exhibited substantial scintillation. The highest emission yields were detected from fluorescein, proflavin and aluminum phthalocyanine, in that order. XML yield was found to be affected by the emission quantum yield, overlap of the fluorescence excitation and Cherenkov emission spectra, scintillation yield. Considering all these factors and XML emission spectrum respective to tissue optical window, aluminum phthalocyanine offers the best XML yield for deep tissue use, while fluorescein and proflavine are most useful for subcutaneous or superficial use.
Cardiac amyloidosis with overt multiple myeloma presenting with pulmonary effusion: case report
Authors: Saad Wajih , Moussa Mohamad , Saad Firas , Dbouk Samer , Bazzi Nagham 
Published: June 2021

Abstract
Amyloidosis was initially described by Nicolaes Fonteyn in 1639. It is caused by the deposition of soluble immunoglobulin light chains as insoluble fibrils and can affect any organ including the heart, nervous system, dermis and subcutaneous tissue, kidneys and liver. This is a rare case of cardiac amyloidosis occurring with multiple myeloma and pleural effusion.
A 65-year-old Arab woman, nonsmoker, nonalcoholic, known to have hypothyroidism and multiple myeloma, presented to the hospital with dyspnea and basilar crackles. Workup was done to exclude leukemia. Cardiac echography showed features of amyloidosis.
Cardiac amyloidosis occurring with multiple myeloma and pleural effusion is rare. However, it is stated that 10–15% of amyloidosis patients might develop multiple myeloma (MM).
Intergalactic filaments spin
Authors: Xia Qianli , Neyrinck Mark C , Cai Yan-Chuan , Aragón-Calvo Miguel A 
Published: June 2021

ABSTRACT
Matter in the Universe is arranged in a cosmic web, with a filament of matter typically connecting each neighbouring galaxy pair, separated by tens of millions of light-years. A quadrupolar pattern of the spin field around filaments is known to influence the spins of galaxies and haloes near them, but it remains unknown whether filaments themselves spin. Here, we measure dark matter velocities around filaments in cosmological simulations, finding that matter generally rotates around them, much faster than around a randomly located axis. It also exhibits some coherence along the filament. The net rotational component is comparable to, and often dominant over, the known quadrupolar flow. The evidence of net rotations revises previous emphasis on a quadrupolar spin field around filaments. The full picture of rotation in the cosmic web is more complicated and multiscale than a network of spinning filamentary rods, but we argue that filament rotation is substantial enough to be an essential part of the picture. It is likely that the longest coherently rotating objects in the Universe are filaments. Also, we speculate that this rotation could provide a mechanism to generate or amplify intergalactic magnetic fields in filaments.
A new strategy for matching observed and simulated lensing galaxies
Authors: Denzel Philipp , Mukherjee Sampath , Saha Prasenjit 
Published: June 2021

ABSTRACT
The study of strong-lensing systems conventionally involves constructing a mass distribution that can reproduce the observed multiply imaging properties. Such mass reconstructions are generically non-unique. Here, we present an alternative strategy: instead of modelling the mass distribution, we search cosmological galaxy-formation simulations for plausible matches. In this paper, we test the idea on seven well-studied lenses from the SLACS survey. For each of these, we first pre-select a few hundred galaxies from the EAGLE simulations, using the expected Einstein radius as an initial criterion. Then, for each of these pre-selected galaxies, we fit for the source light distribution, while using MCMC optimization for the placement and orientation of the lensing galaxy, so as to reproduce the multiple images and arcs. The results indicate that the strategy is feasible and can easily reject unphysical galaxy-formation scenarios. It even yields relative posterior probabilities of two different galaxy-formation scenarios, though these are not statistically significant yet. Extensions to other observables, such as kinematics and colours of the stellar population in the lensing galaxy, are straightforward in principle, though we have not attempted it yet. Scaling to arbitrarily large numbers of lenses also appears feasible. This will be especially relevant for upcoming wide-field surveys, through which the number of galaxy lenses will rise possibly a hundredfold, which will overwhelm conventional modelling methods.
Multipoint remote and in situ observations of interplanetary coronal mass ejection structures during 2011 and associated geomagnetic storms
Authors: Mishra Wageesh , Dave Kunjal , Srivastava Nandita , Teriaca Luca 
Published: June 2021

ABSTRACT
We present multipoint remote and in situ observations of interplanetary coronal mass ejection (ICME) structures during the year 2011. The selected ICMEs arrived at Earth on 2011 March 11 and 2011 August 6, and led to geomagnetic storms. Around the launch of these CMEs from the Sun, the coronagraphs onboard STEREO-Aand-B and SOHO enabled the CMEs to be imaged from three longitudinally separated viewpoints. We attempt to identify the in situ plasma and magnetic parameters of the ICME structures at multiple locations, for example at both STEREO spacecraft and also at the ACE/Wind spacecraft near the first Sun–Earth Lagrangian point (L1), to investigate the global configuration, interplanetary propagation, arrival times and geomagnetic response of the ICMEs. The near-Earth identified ICMEs of March 11 and August 6 formed as a result of the interaction of two successive CMEs observed in the inner corona on March 7 (for the March 11 ICME) and on August 3–4 (for the August 6 ICME). Our study suggests that the structures associated with interacting CMEs, possibly as a result of deflection or large sizes, may reach to even larger longitudinally separated locations in the heliosphere. Our multipoint in situ analysis shows that the characteristics of the same shock, propagating in a pre-conditioned medium, may be different at different longitudinal locations in the heliosphere. Similarly, multiple cuts through the same ejecta/complex ejecta, formed as a result of CME–CME interaction, are found to have inhomogeneous properties. The study highlights the difficulties in connecting the local observations of an ICME from a single in situ spacecraft to its global structures.
Compilation of selenium metabolite data in selenized yeasts
Authors: LeBlanc Kelly L , Mester Zoltán 
Published: June 2021

Abstract
Selenium-enriched yeast has long been recognized as an important nutritional source of selenium and studies have suggested that supplementation with this material provides chemo-preventative benefits beyond those observed for selenomethionine supplementation, despite the fact that selenomethionine accounts for 60–84% of the total selenium in selenized yeasts. There is much ongoing research into the characterization of the species comprising the remaining 16–40% of the selenium, with nearly 100 unique selenium-containing metabolites identified in aqueous extracts of selenized yeasts (Saccharomyces cerevisiae). Herein, we discuss the analytical approaches involved in the identification and quantification of these metabolites, and present a recently created online database (DOI: 10.4224/40001921) of reported selenium species along with chemical structures and unique mass spectral features.
Thermal Neuromodulation With Focused Ultrasound: Implications for the Technique of Subthreshold Testing
Authors: Sammartino Francesco , Snell John , Eames Matthew , Krishna Vibhor 
Published: June 2021

Abstract

BACKGROUND
During focused ultrasound ablation (FUSA), the presumed stereotactic target is tested with subthreshold sonications before permanent ablation. This testing relies on ultrasound-induced reversible clinical effects (thermal neuromodulation, TN). However, the thermal dose and spot size thresholds to induce TN are not yet defined.

OBJECTIVE
To define the thermal dose and spot size thresholds associated with TN.

METHODS
We performed a retrospective analysis of intraoperative FUSA data of essential tremor patients. Sonications with a thermal dose of less than 25 cumulative equivalent minutes (CEM) were classified as subthreshold. The intraoperative writing samples were independently rated by 2 raters using the clinical rating scale for tremor. The association between thermal dose and tremor scores was statistically analyzed, and the thermal dose and spot size thresholds for TN were computed using leave-one-out cross-validation analysis.

RESULTS
A total of 331 pairs of sonications and writing samples were analyzed; 97 were classified as subthreshold sonications. TN was observed in 23 (24%) subthreshold sonications. The median tremor improvement during TN was 20% (interquartile range = 41.6). The thermal dose threshold for TN was 0.67 CEM (equivalent to 30 s thermal exposure at 43°C). The spot size threshold for TN was 2.46 mm. Ventral intermediate medial nucleus was exposed to TN thermal dose during subablative and ablative sonications.

CONCLUSION
The TN thermal dose and spot size thresholds are significantly higher than the current FUSA standard of care. We recommend long duration (>30 s), subthreshold sonications for intraoperative testing during FUSA. Future investigations should test whether the thermal dose threshold is tissue-specific and determine the mechanisms underlying focused ultrasound TN.
Cow’s milk may be delivering potentially harmful undetected cargoes to humans. Is it time to reconsider dairy recommendations?
Authors: Wehbe Zena , Kreydiyyeh Sawsan 
Published: June 2021

Abstract
Mammalian evolution has shaped milk into a species-specific vehicle for post-natal development, continuing what began within the mother’s womb. Increased consumption of the mother’s breast milk is associated with the most adequate metabolic programming and lowers the incidence of the diseases of civilization during adulthood. An abundance of short sequences of RNA, known as microRNA, exists in mammalian breast milk, enclosed within robust small extracellular vesicles known as exosomes. These microRNAs can epigenetically regulate over 60% of human genes. When cow’s milk is consumed by humans, the bovine exosomes are transported through the gastrointestinal tract, detected intact in the blood stream, and taken up by target cells, where they alter protein expression. The aim of this review was to highlight the role of dairy exosomes and microRNA, and of the type of dairy product consumed, in human diseases. Given that microRNAs are involved in a vast array of physiological processes and associated with several diseases, perhaps caution should be practiced with regard to human consumption of dairy, particularly for individuals within developmentally critical time frames, such as pregnant and lactating mothers, and young children.
Emerging Technologies in Spinal Surgery: Ultra-Low Radiation Imaging Platforms
Authors: Pacult Mark A , Walker Corey T , Godzik Jakub , Turner Jay D , Uribe Juan S 
Published: June 2021

Abstract

BACKGROUND
Spine surgery has seen tremendous growth in the past 2 decades. A variety of safety, practical, and market-driven needs have spurred the development of new imaging technologies as necessary tools for modern-day spine surgery. Although current imaging techniques have proven satisfactory for operative needs, it is well-known that these techniques have negative consequences for operators and patients in terms of radiation risk. Several mitigating techniques have arisen in recent years, ranging from lead protection to radiation-reducing protocols, although each technique has limits. A hitherto-problematic barrier has been the fact that efforts to diminish radiation emission come at the cost of reduced image quality.

OBJECTIVE
To describe new ultra-low radiation imaging modalities that have the potential to drastically reduce radiation risk and minimize unacceptable adverse effects.

METHODS
A literature review was performed of articles and studies that used either of 2 ultra-low radiation imaging modalities, the EOS system (EOS-Imaging S.A., Paris, France) and LessRay (NuVasive, San Diego, CA).

RESULTS
Both ultra-low radiation imaging modalities reduce radiation exposure in the preoperative and perioperative settings. EOS provides 3-dimensional reconstructive capability, and LessRay offers intraoperative tools that facilitate spinal localization and proper visual alignment of the spine.

CONCLUSION
These novel radiation-reducing technologies diminish patient and surgeon exposure, aid the surgeon in preoperative planning, and streamline intraoperative workflow.
Expandable Cage Technology—Transforaminal, Anterior, and Lateral Lumbar Interbody Fusion
Authors: Macki Mohamed , Hamilton Travis , Haddad Yazeed W , Chang Victor 
Published: June 2021

Abstract
This review of the literature will focus on the indications, surgical techniques, and outcomes for expandable transforaminal lumbar interbody fusion (TLIF), anterior lumbar interbody fusion (ALIF), and lateral lumbar interbody fusion (LLIF) operations. The expandable TLIF cage has become a workhorse for common degenerative pathology, whereas expandable ALIF cages carry the promise of greater lordotic correction while evading the diseased posterior elements. Expandable LLIF cages call upon minimally invasive techniques for a retroperitoneal, transpsoas approach to the disc space, obviating the need for an access surgeon and decreasing risk of injury to the critical neurovascular structures. Nuances between expandable and static cages for all 3 TLIF, ALIF, and LLIF operations are discussed in this review.