bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticoagulation Therapy for Portal Vein Thrombosis in Patients with Cirrhosis in a Tertiary Center Experience
Authors: Florescu Marieta Madalina , Costache Adrian , Iacob Speranta Maria , Pietrareanu Corina , Ester Carmen , Cerban Razvan , Dumitru Radu , Grasu Mugur , Lupescu Ioana , Gheorghe Liana 
Published: November 2021

Background and Aims: The evidence regarding the use of anticoagulant (AC) agents in portal vein thrombosis (PVT) is increasing and, most patients undergo chronic treatment with low molecular weight heparin (LMWH) or vitamin K antagonists (VKA). Nevertheless, there are no clear data about who should receive antithrombotic therapy, when to initiate it, how long and what dose should be used for this set of patients. The aim of the study was to assess the outcome of patients with cirrhosis and portal vein thrombosis who received AC therapy, in terms of thrombus regression, bleeding events and survival rates.
Methods: This observational and retrospective study included 107 cirrhotic patients diagnosed with PVT in a single tertiary center between 2010-2019. 54 received low molecular weight heparin or vitamin K antagonist (AC treatment group) and 53 were untreated. All patients were periodically follow-up to assess the evolution of PVT (regression, progression, stable thrombus) and potential occurrence of bleeding events.
Results: The regression of portal vein thrombosis was significantly higher in the AC treatment group (OR=2.430; 95% CI=1.11-6.167; p=0.026), more than 50% of on-treatment patients experiencing regression of the thrombus. However, bleeding events were significantly more frequent in the AC treatment group (18.5% vs. 7.5%) and the risk of bleeding was associated with thrombocytes less than 50x103/mm3 (OR=8.266; 95%CI: 2.310-39.211; p=0.002). Survival was better in the AC treatment group (68.4% vs 48.7% at 5 years and 92.7% vs 77.8% at 1 year, p=0.038) and was lower in patients that experienced bleeding events (37.22% survival at 5 years, mean time survival 44 months, p=0.008).
Conclusions: In our cohort of cirrhotic patients with PVT more than 50% of patients receiving AC therapy presented regression of the thrombus; most of them obtained partial recanalization. The bleeding complication rate was higher than expected, reaching 18%. The overall mortality was lower in the treated group.
Comparative Efficacy and Tolerability of Janus Kinase Inhibitor Therapies for Moderate to Severe Crohn’s Disease: Α Network Meta-analysis
Authors: Rokkas Theodoros , Ekmektzoglou Konstantinos , Niv Yaron 
Published: November 2021

Background and Aims: A number of Janus kinase (JAK) inhibitors (tofacitinib, filgotinib, upadacitinib) have been tested for moderate and severe Crohn’s disease (CD) in randomized control trials (RCTs). However, data on their comparative efficacy and tolerability is lacking. We aimed to study their performance comparatively, by means of network meta-analysis (NWM).
Methods: We searched the Pubmed/Medline, EMBASE, and Cochrane Library databases for relevant RCTs through March 2021 and data was extracted. A bayesian NWM was performed to investigate the efficacy and tolerability of the above JAK inhibitors and to explore their rank order in treating moderate and severe CD patients. The cumulative ranking probability for each intervention at the end of treatment period, was evaluated by means of surfaces under cumulative ranking (SUCRA) values.
Results: Four RCTs were entered into this NWM. They included 811 patients totally, randomized to 11 interventions, i.e. placebo, tofacitinib (1mg BID, 5mg BID, 10mg BID, 15mg BID), filgotinib 200 OD and upadacitinib (3 mg BID, 6 mg BID, 12 mg BID, 24 mg BID and 24mg OD). Two upadacitinib doses (6 mg BID and 24 mg BID) and filgotinib 200 OD, performed best as judged by the relevant forest plots, league matrixes, rankograms, SUCRA values (96.7%, 84,6 %and 78,7%, respectively) and the clustered ranking plots for efficacy and tolerability.
Conclusions: Upadacitinib 6 mg BID, upadacitinib 24 mg BID and filgotinib 200 OD performed better as induction therapies in comparison to control therapies. Consequently, these regimens may play a therapeutic role in CD and therefore they merit further evaluation with well-designed RCTs.
Urban Classification, Not COVID-19 Community Rates, Was Associated With Modes of Learning in US K–12 Schools?
Authors: Goldman Jennifer L. , Schuster Jennifer E. , Maier Vanessa F. , Anand Rohit , Hill Elizabeth E. , Butteris Sabrina M. , DeMuri Gregory P. , Omidfar Samantha A. , Brookhart M. Alan , Pak Joyce , Benjamin Daniel K. , Zimmerman Kanecia O. 
Published: November 2021

OBJECTIVES
To identify factors associated with the decision to provide in-person, hybrid, and remote learning in kindergarten through 12th grade school districts during the 2020–2021 school year.

METHODS
We performed a retrospective study evaluating school district mode of learning and community coronavirus 2019 (COVID-19) incidence and percentage positivity rates at 3 time points during the pandemic: (1) September 15, 2020 (the beginning of the school year, before Centers for Disease Control and Prevention guidance); (2) November 15, 2020 (midsemester after the release of Centers for Disease Control and Prevention guidance and an increase of COVID-19 cases); and (3) January 15, 2021 (start of the second semester and peak COVID-19 rates). Five states were included in the analysis: Michigan, Missouri, North Carolina, Ohio, and Wisconsin. The primary outcome was mode of learning in elementary, middle, and high schools during 3 time points. The measures included community COVID-19 incidence and percentage positivity rates, school and student demographics, and county size classification of school location.

RESULTS
No relationship between mode of learning and community COVID-19 rates was observed. County urban classification of school location was associated with mode of learning with school districts in nonmetropolitan and small metropolitan counties more likely to be in-person.

CONCLUSIONS
Community COVID-19 rates did not appear to influence the decision of when to provide in-person learning. Further understanding of factors driving the decisions to bring children back into the classroom are needed. Standardizing policies on how schools apply national guidance to local decision-making may decrease disparities in emergent crises.
Load-deformation behaviour of weft-knitted textile reinforced concrete in uniaxial tension
Authors: Lee Minu , Mata-Falcón Jaime , Kaufmann Walter 
Published: November 2021

AbstractWeft-knitted textiles offer many advantages over conventional woven fabrics since they allow the fabrication of doubly curved geometries without the need of stitching multiple patches together. This study investigated the use of high-strength continuous fibres as knitted textile reinforcement, focusing on various knitting patterns, fibre materials, coating types and spatial features to enhance the bond conditions between concrete and reinforcement. The bond is of particular interest since the contact surface of knitted textiles is fundamentally different due to their closed surface, compared to commercially available textile reinforcement, which is normally formed as orthogonally woven grids of rovings. An experimental campaign consisting of 28 textile-concrete composites was conducted, where digital image correlation-based measurements were used to assess the load-deformation behaviour and to analyse the crack kinematics. The results showed a beneficial post-cracking behaviour for epoxy coated configurations with straight inlays. The comparison of these configurations with conventional textile reinforcement generally showed a similar behaviour, but with higher utilisation compared to the filament strength. The Tension Chord Model, which assumes a constant bond stress-slip relationship, was adapted for the specific geometry of the knitted reinforcement, and it was used for the estimation of bond stresses and a post-diction of the experimental results, generally showing a good agreement.
Research on risk designation and small raised reservoirs
Authors: Penman James G. , Golds Simon R. , Raja Omar H. 
Published: November 2021

The Department for Environment, Food and Rural Affairs (Defra) awarded a contract to Mott MacDonald in March 2017 for ‘Applying a risk-based approach and improving the evidence base related to small raised reservoirs’. The project was delivered between March 2017 and October 2019. High-level objectives of the contract were: Objective 1: provide evidence to feed into a post-implementation review of the first phase of the Flood and Water Management Act 2010 (FWMA 2010) reservoir provisions. Objective 2: provide evidence on the number of small raised reservoirs (SRRs) and the risk they pose. Objective 3: consider refinements to the current risk-based approach and methodology, including taking into account probability of failure and reservoir type (e.g. service reservoirs) for assessing reservoir risk and exemptions and to provide evidence to inform decisions about whether to implement certain aspects of the FWMA 2010. The research findings are summarised in this paper and conclusions are given in full in the original research reports. The purpose of the project was to provide evidence to the client on reservoir safety in England but not to make recommendations on future legislation. This research study including images and data are based on the research reports published by the client.
Elaboración de nanopartículas de plata sintetizadas a partir de extracto de hojas de romero (Rosmarinus officinalis L.) y su uso como conservante
Authors: Pardo Lucas , Arias Jason , Molleda Patricia 
Published: November 2021

Las nanopartículas son materiales que pueden llegar a medir entre 1 a 100 nm de longitud, y en la actualidad la propiedad antimicrobiana de las nanopartículas de plata es aprovechada por las industrias para la fabricación de productos de belleza y medicamentos. Las nanopartículas pueden ser sintetizadas a partir de plantas, algas o microorganismos, y también pueden ser obtenidas como productos de combustión. En este estudio se utilizaron extractos de las hojas de romero (Rosmarinus officinalis L.) para la síntesis de nanopartículas de plata (NPs-Ag) con la finalidad de producir un compuesto antimicrobiano para usarse como conservante de frutas. Las NPs-Ag se caracterizaron cualitativa y cuantitativamente mediante análisis fitoquímicos y espectroscopia UV-VIS, presentando una absorción en el rango de 389-418 nm, que corresponde a la resonancia de su plasmón superficial. Además, se empleó la microscopía electrónica de barrido para determinar el tamaño y morfología de las NPs-Ag, observándose una forma esférica de 10 nm de diámetro. Se emplearon dos cepas bacterianas en los ensayos antimicrobianos realizados, la gramnegativa (Escherichia coli) y la grampositiva (Staphylococcus aureus) para comprobar la actividad antimicrobiana de las NPs-Ag. Para E. coli se obtuvo una mejor actividad antibacteriana con un halo de inhibición de 3,21 mm. Posteriormente se usaron las NPs-Ag en manzanas para determinar su uso como conservante, usando la cera de abeja como control untada en la superficie de las frutas, observándose que las nanopartículas sintetizadas alargaron el tiempo de maduración de la frutas.
KINERJA KARYAWAN STUDI PADA BANK X [EMPLOYEE PERFORMANCE AT BANK X]
Authors: Anggarian Inga , Meilani Yohana F. Cahya Palupi 
Published: November 2021

<p>The purpose of this study was to determine the effect of caring climate, affective commitment, job satisfaction on employee performance at Bank X in Jakarta and Tangerang. This research is a quantitative research with descriptive method, the data used is primary data with survey data collection techniques using an online questionnaire Google Form using a Likert scale to 150 respondents who are employees of Bank X in Jakarta and Tangerang. Data processing using SPSS 26.0 software. This study has four hypotheses tested that are valid and reliable. This study shows that a caring climate has a positive effect on job satisfaction (H1), a caring climate has no positive effect on affective commitment (H2), a caring climate has no positive effect on performance (H3), job satisfaction has a positive effect on affective commitment (H4), job satisfaction work has a positive effect on performance (H5), affective commitment has no positive effect on performance (H6), caring climate has no indirect effect on performance through mediation of affective commitment (H7), and job satisfaction has a positive effect on performance by mediating affective commitment (H8) at Bank X in Jakarta and Tangerang. The contribution of this research provides input for banking managers in improving employee performance through job satisfaction which is built from a caring climate and affective commitment.</p><p><strong>BAHASA INDONESIA ABSTRACT:</strong></p><p>Tujuan dari penelitian ini untuk mengetahui pengaruh iklim peduli, komitmen afektif, kepuasan kerja terhadap kinerja karyawan pada Bank X di Jakarta dan Tangerang. Penelitian ini merupakan penelitian kuantitatif dengan metode deskriptif, data yang digunakan adalah data primer dengan teknik pengumpulan data survei menggunakan kuesioner <em>online Google Form </em>menggunakan skala Likert kepada 150 responden yang merupakan karyawan Bank X di Jakarta dan Tangerang. Penggolahan data menggunakan <em>software </em>SPSS 26.0. Penelitian ini memiliki empat hipotesis yang diuji bersifat<em> </em>valid dan <em>reliab</em><em>le</em><em>. </em>Penelitian ini menunjukkan bahwa iklim peduli berpengaruh positif terhadap kepuasan kerja (H1), iklim peduli tidak berpengaruh positif terhadap komitmen afektif (H2), iklim peduli tidak berpengaruh positif terhadap kinerja (H3), kepuasan kerja berpengaruh positif terhadap komitmen afektif (H4), kepuasan kerja berpengaruh positif terhadap kinerja (H5), komitmen afektif tidak berpengaruh positif terhadap kinerja (H6), iklim peduli tidak berpengaruh tidak langsung terhadap kinerja melalui mediasi komitmen afektif (H7), dan kepuasan kerja berpengaruh positif terhadap kinerja dengan mediasi komitmen afektif (H8) pada Bank X di Jakarta dan Tangerang. Kontribusi penelitian ini memberi input bagi pengelola perbankan dalam meningkatkan kinerja karyawan melalui kepuasan kerja yang dibangun dari iklim peduli dan komitmen afektif.</p>
DRIVING BRAND LOYALTY IN CREATIVE CULINARY INDUSTRY
Authors: Butar Butar Ivan Destian , Pratama Mohammad Harry , Pangaribuan Christian Haposan 
Published: November 2021

<p>The government has emphasized the increasing number of the creative culinary industry in Indonesia to increase support in this area. One of the flourishing brands running a creative culinary business in Indonesia is Warunk Upnormal. The growth of the player in this industry has grown some concern about such business's sustainability since the related industry has low entry barriers. This research aims to know how well the known drivers of brand loyalty, including variables brand awareness, perceived quality, brand image, perceived value, pleasure, and customer satisfaction, affect brand loyalty in Warunk Upnormal. This research used a quantitative method in finding the relationships among variables and used primary data to be processed. The design and development of the questionnaire are based on the pretested model and distributed toward 208 respondents. The overall result of this research shows that perceived quality affects most toward pleasure, followed by perceived value, then brand awareness. This research also shows the positive and significant relationship of pleasure toward customer satisfaction and customer satisfaction toward brand loyalty.</p><p> </p>
STRATEGY COMMUNITY EMPOWERMENT THROUGH THE DEVELOPMENT OF TANI BETET TOURISM IN NGANJUK REGENCY, EAST JAVA
Authors: Anggi Defita Dwi , Purnomo Agus , Ruja I Nyoman 
Published: November 2021

The research aims to formulate a strategy for community empowerment by developing the Tani Betet Tourist destination in Nganjuk Regency, East Java. The method used is a quantitative method with SWOT analysis. The number of respondents was 20 people and one key informant. The number of respondents is as many as 20 people and key respondents 1 person. The results of this study are strategies used in community empowerment in Tani Betet Tourism, which are contained in quadrant I (Progressive Strategy). Strategies that can be done in the development of Tani Betet Tourism is to maximize the role of the community in supporting packaging and promoting tourism that has the opportunity to increase tourist visits. Utilization of community empowerment programs in sustainable tourism development. The active role of local governments is to give rise to trust in each other in society to accept the technological developments present. The benefits of this research provide strategies as a reference in optimizing community empowerment in Tani Betet Tourism, for tourism development through community empowerment programs.
An Uncommon Complication of Ankle Varus During Tibial Transport in an Ilizarov Frame
Authors: Gupta Vikas , Champawat Vishal , Behera Prateek , Garnayak Sibasis 
Published: November 2021

Case:
We treated a 22-year-old man with an infected fracture of the tibia by resection of necrosed bone and bone transport with an Ilizarov device. Four weeks after initiation of transport, an ankle varus deformity from distal migration of the fibula was noticed. A wire that had been incorrectly placed through both the fibula and the transport fragment of the tibia was identified as responsible for this complication. It was changed after an acute reversal of the transport.

Conclusion:
Errors in the surgical technique during the insertion of Ilizarov wires can result in unusual complications. Attention to details is a must to avoid them.
Bottlenecks and Opportunities towards Achieving the Targeted 95-95-95 HIV Services in a Rural District in Eastern Uganda
Authors: Namenkere Monkya Samuel , Stella Ayaa Mary , Linda Sukuku , Juliet Kharono , Charles Mugabi , Benina Chelangat , Olwedo Mary Abwola , Nabasumba Carol , Oboth Paul , Osele Julius , Nekaka Rebecca , Iramiot Jacob Stanley 
Published: November 2021

Abstract
Background: There are 1.3 million people living with HIV in Uganda of which 73% know their HIV-positive status, 67% of the HIV-positive patients on ART, and 60% are viral load suppressed. Uganda has made progress in reducing the HIV prevalence from 7.3% in 2011 to 6% in 2017, however, more needs to be done to meet the WHO target of 95% of the population knowing their HIV status, 95% enrolled on treatment and 95% achieving viral suppression. This study aimed to assess the bottlenecks and opportunities towards achieving the 95 95 95 targeted HIV services in Bukedea district. Methods: A mixed-methods cross-sectional study was conducted in Bukedea district covering males and females aged 18-65 years who had consented to participate in the study. We used a purposive sampling procedure to select our study participants. Qualitative data was collected through focus group discussions, key informant interviews, and document reviews for quantitative data. Quantitative data were analyzed using STATA v 14 whereas qualitative data were analyzed using the thematic analysis approach. Results: The challenges were grouped as patient-related, medication-related, and facility-related challenges. The patient-related challenges were stigma, fear to take the drugs, poor nutrition, long distances, alcoholism, busy working schedules, domestic violence. The medication-related 2 challenges were side effects, pill burden. The facility-related challenges were inadequate pretest counseling, stockouts. The use of anti-retroviral drugs was common in piggery and poultry and the sources of these drugs were reported to be the people on ART and the health workers. The opportunities included home-based counseling, organizing more outreaches, counseling and health education, targeted testing, and strengthening the VHT networks. Conclusion: The study revealed that the major challenges towards achieving the targeted 95-95- 95 HIV services were stigma, inadequate pre-test counseling, fear of disclosure, and poor adherence due to alcoholism, sharing of drugs with animals and partners. The use of Antiretroviral drugs in animal husbandry was common in Bukedea District. Continuous sensitization about HIV and the importance of adherence to drugs, continuous and adequate counseling of the clients on ART, and close monitoring of their viral load could help to improve enrollment into care, adherence to HIV treatment, and HIV viral load suppression.
Link prediction of viral spike proteins and cell receptors using structural perturbation method
Authors: Zhou Iris 
Published: November 2021

Abstract
Many protein receptors for animal and human viruses have been discovered in decades of studies. The main determinant of virus entry is the binding of the viral spike protein to host cell receptors, which mediates membrane fusion. In this work, a bilayer network is constructed by integrating the similarity network of the viral spike proteins, the similarity network of host receptors, and the association network between viruses and receptors. The structural perturbation method (SPM) is used to predict possible emerging infection of a virus in potential new host organisms. The reliability of this method is based on the hypothesis that the major barrier to virus infection is the differences in the compatibility of spike proteins and cell receptors, which is determined by the amino acid sequences among species.
The application of WT1 and P53/Ki-67 to predict the recurrence of epithelial ovarian cancer
Authors: Chen Yue , Zhang Yi , Zhou Jinhua , Wang Juan , Shen Fangrong , Chen Youguo 
Published: November 2021

Abstract
Purpose: To evaluate the ability of WT1 alone, and in combination with P53/Ki-67, to predict recurrence in patients with epithelial ovarian cancer (EOC).Methods: In this retrospective study, we performed immunohistochemistry on surgical specimens acquired from 137 patients with EOC. We analyzed the sensitivity of WT1 alone, and in combination with P53 and Ki-67, to predict the recurrence of EOC by applying Chi-squared and layered Chi-squared tests. The Kaplan–Meier method was used to predict progression-free survival(PFS).Results: The proportion of WT1-positive patients in the recurrent group (80.4%) was significantly higher than that in the non-recurrent group (60.4%; P=0.019). In stratified cohort analysis, the recurrence rate of WT1-positive patients was significantly higher than that of WT1-negative patients in the P53-positive group (P=0.034); similar results were obtained for the group with Ki-67 index >30% (P=0.026). Kaplan–Meier curves showed that WT1-negative patients presented with a significantly longer PFS than WT1-positive patients in the P53(P=0.006) and Ki-67(P=0.016) positive groups.Conclusion: A high level of WT1 is a potent predictor of recurrence for EOC. Our analyses showed that the predictive ability of WT1 was more sensitive when combined with P53/Ki-67. Monitoring the levels of WT1 could have significant therapeutic implications for patients with EOC.
Continuously tunable photonic radio frequency and microwave orthogonally polarized single sideband generator using Kerr micro-combs
Authors: Moss David 
Published: November 2021

Abstract
We demonstrate a continuously RF tunable orthogonally polarized optical single sideband (OP-OSSB) generator based on dual cascaded micro-ring resonators. By splitting the input double sideband signal into an orthogonally polarized carrier and lower sideband via TE- and TM-polarized MRRs, an OP-OSSB signal is generated. A large tuning range of the optical carrier to sideband ratio of up to 57.3 dB is achieved by adjusting the polarization angle of the input light. The operation RF frequency of the OP-OSSB generator can be continuously tuned with a 21.4 GHz range via independent thermal control of the two MRRs. Our device represents a competitive approach towards OP-OSSB generation with wideband tunable RF operation, and is promising for photonic RF signal transmission and processing in radar and communication systems.