bluuebunny/crossref_metadata_2025_split huggingface dataset:
Registration of ‘Driver’ hard red spring wheat
Authors: Glover K. D. , Kleinjan J. L. , Graham C. , Ali S. , Byamukama E. , Jin Y. , Ingemansen J. A. , Turnipseed E. B. , Dykes L. 
Published: September 2021

AbstractWidespread acceptance of new hard red spring wheat (HRSW; Triticum aestivum L). cultivars by South Dakota growers relies heavily on a favorable combination of essential production characteristics, such as agronomic performance, resistance to prominent diseases, and acceptable end‐use quality potential. Additional characteristics, however, such as lodging resistance are also important to growers. Steadily increasing levels of lodging resistance in new cultivar releases are a significant goal of the South Dakota State University (SDSU) HRSW breeding program. The objective of this research was to release a new HRSW cultivar with elevated resistance to lodging that is also capable of meeting grower expectations with respect to essential production characteristics. ‘Driver’ (Reg. no. CV‐1187, PI 698121) was developed by the SDSU‐HRSW breeding program and released by the South Dakota Agricultural Experiment Station (SDAES) to Certified seed producers in early 2020. The cross MN06075‐4/SD4165 was completed during spring 2011 and the resulting population was advanced via an early‐generation bulk‐testing program where F4:7 seed was included in the 2015 preliminary yield trial and designated as SD4625. Prior to release, SD4625 also was tested in the advanced yield trial from 2016 through 2019 as well as crop performance testing trials from 2017 through 2019. Driver was released for its combination of agronomic potential, disease resistance, acceptable end‐use quality, and lodging resistance.
NMR hawk‐eyed view of AlphaFold2 structures
Authors: Zweckstetter Markus 
Published: September 2021

AbstractThe prediction of the three‐dimensional (3D) structure of proteins from the amino acid sequence made a stunning breakthrough reaching atomic accuracy. Using the neural network‐based method AlphaFold2, 3D structures of almost the entire human proteome have been predicted and made available (https://www.alphafold.ebi.ac.uk). To gain insight into how well AlphaFold2 structures represent the conformation of proteins in solution, I here compare the AlphaFold2 structures of selected small proteins with their 3D structures that were determined by nuclear magnetic resonance (NMR) spectroscopy. Proteins were selected for which the 3D solution structures were determined on the basis of a very large number of distance restraints and residual dipolar couplings and are thus some of the best‐resolved solution structures of proteins to date. The quality of the backbone conformation of the AlphaFold2 structures is assessed by fitting a large set of experimental residual dipolar couplings (RDCs). The analysis shows that experimental RDCs fit extremely well to the AlphaFold2 structures predicted for GB3, DinI, and ubiquitin. In the case of GB3, the accuracy of the AlphaFold2 structure even surpasses that of a 1.1 Å crystal structure. Fitting of experimental RDCs furthermore allows identification of AlphaFold2 structures that are best representative of the protein's conformation in solution as seen for the EF hands of the N‐terminal domain of Ca2+‐ligated calmodulin. Taken together, the analysis shows that structures predicted by AlphaFold2 can be highly representative of the solution conformation of proteins. The combination of AlphaFold2 structures with RDCs promises to be a powerful approach to study structural changes in proteins.
Prioritizing the candidate genes related to cervical cancer using the moment of inertia tensor
Authors: Thummadi Neelesh Babu , T. Mallikarjuna , Vindal Vaibhav , P. Manimaran 
Published: September 2021

AbstractIt is well known that cervical cancer poses the fourth most malignancy threat to women worldwide among all cancer types. There is a tremendous improvement in realizing the underlying molecular associations in cervical cancer. Several studies reported pieces of evidence for the involvement of various genes in the disease progression. However, with the ever‐evolving bioinformatics tools, there has been an upsurge in predicting numerous genes responsible for cervical cancer progression and making it highly complex to target the genes for further evaluation. In this article, we prioritized the candidate genes based on the sequence similarity analysis with known cancer genes. For this purpose, we used the concept of the moment of inertia tensor, which reveals the similarities between the protein sequences more efficiently. Tensor for moment of inertia explores the similarity of the protein sequences based on the physicochemical properties of amino acids. From our analysis, we obtained 14 candidate cervical cancer genes, which are highly similar to known cervical cancer genes. Further, we analyzed the GO terms and prioritized these genes based on the number of hits with biological process, molecular functions, and their involvement in KEGG pathways. We also discussed the evidence‐based involvement of the prioritized genes in other cancers and listed the available drugs for those genes.
Vapor heat treatment against Planococcus lilacinus Cockerell (Hemiptera:Pseudococcidae) on dragon fruit
Authors: Ren Lili , Qian Lu , Xue Meiling , Peng Caiyun , Chen Naizhong , Zhan Guoping , Liu Bo 
Published: September 2021

AbstractBACKGROUNDThe coffee mealybug Planococcus lilacinus Cockerell, is an invasive pest that infests dragon fruit [Selenicereus undatus (Haworth) D.R. Hunt], that may require a phytosanitary treatment to meet quarantine requirements. In this study, vapor heat treatment was conducted to disinfest P. lilacinus on dragon fruit and the quality of dragon fruit was evaluated thereafter.RESULTSAdult female P. lilacinus was the most heat‐tolerant stage at 47, 48 and 49 °C. The death kinetic model and probit model were used to predict LT99.9968 at the three temperatures. The treatment times predicted by the kinetic model that could effectively disinfest adult female P. lilacinus females were 120.84, 78.06 and 67.96 min at 47, 48 and 49 °C, respectively. In a confirmatory test of vapor heat treatment at 49 °C for 70 min, complete mortality was recorded for 33 195 adult females infesting 148 dragon fruits; thus, the efficacy level of disinfestation was 99.9910% at 95% confidence level. The quality of dragon fruit generally was not affected by heat treatment, fruit firmness was increased remarkably and respiration rate was significantly decreased.CONCLUSIONOur result indicates that vapor heat treatment at 49 °C for a duration of 70 min is an effective phytosanitary treatment for control of P. lilacinus on dragon fruit that minimally impacts fruit quality. © 2021 Society of Chemical Industry.
Combination of rhizosphere bacteria isolated from resistant potato plants for biocontrol of potato late blight
Authors: Feng Shun , Jin Liang , Tang Shicai , Jian Yongfei , Li Zhengguo 
Published: September 2021

AbstractBACKGROUNDPotato late blight (PLB) caused by Phytophthora infestans is one of the most devastating plant diseases. The heavy use of chemical control agents is at odds with the development of sustainable and environmentally friendly agriculture practices. It is necessary to screen the antagonistic microorganisms of P. infestans and provide a new choice of PLB biocontrol.RESULTSIn vitro, eight bacterial strains (A, B, C, D, E, F, G, H) isolated from the rhizosphere of resistant potato plants had a significant inhibitory effect on the mycelium growth of P. infestans, and the inhibition rate was 35.02–79.20%. These isolates were assigned to Streptomyces, Pseudomonas, Saccharothrix and Nocardiopsis by phylogenetic analysis of 16S rRNA genes. Their physiological and biochemical characteristics suggested that they can produce cellulase and catalase, which may help to inhibit the infection of P. infestans. In vivo, each strain significantly inhibited the infection of P. infestans after individual inoculation into potato tubers, and no strains posed a pathogenic threat to tubers. In the field environment, multibacterial treatment significantly reduced the disease index. Compared with the control, multibacterial and single H treatment significantly increased the microbial species and abundance of the potato rhizosphere and enriched potential beneficial bacteria such as Rhizobiaceae. Meanwhile, multi‐bacterial and single H treatment significantly reduced the abundance of Enterobacteriaceae and Bacillaceae.CONCLUSIONOur results provide some valuable native strains from the potato rhizosphere with the ability to inhibit P. infestans in vivo and in vitro, which may be a new option for PLB biocontrol. © 2021 Society of Chemical Industry.
Recent Advances in Synthesis of Pyrazole Derivatives using Functionalized Catalysts Immobilized on Silica
Authors: Mustafa Atif , Siddiqui Shaheen , Umar Khan Mohd , Qasem Ali Abdulaziz Abdullah , Siddiqui Zeba N. 
Published: September 2021

AbstractThe pyrazole moiety is found as an integral structural unit in a variety of pharmacologically and agrochemically significant chemicals. The anti‐inflammatory (celecoxib), anti‐obesity (rimonabant), analgesic (difenamizole), antipsychotic (CDPPB), H2‐receptor agonist (betazole), and antidepressant (fezolamide) activities of pyrazole‐based drugs have demonstrated their pharmacological importance. Various synthetic methodologies have been devised as a result of the above‐mentioned advantages of pyrazole‐based compounds, including solvent‐free approach, catalyst‐free method, homogeneous catalysis, heterogeneous catalysis, microwave irradiation technique, ultrasonication, etc. In the area of heterogeneous catalysis, silica functionalized catalysts have garnered a lot of interest among diverse heterogeneous catalysts. The significant advancements in silica functionalized heterogeneous catalysts for the production of pyrazole‐based compounds are highlighted in this review.
Enhanced Water Splitting Reaction Performance using TiO2 Deposited with Graphene Quantum Dots Grafted onto Gold Nanoparticles
Authors: Sangkhun Weradesh , Wanwong Sompit , Wootthikanokkhan Jatuphorn , Sinthiptharakoon Kitiphat , Kumnorkaew Pisist 
Published: September 2021

AbstractThis study explores the feasibility of enhancing the water splitting performance of hybrid photo‐electrocatalyst made from graphene quantum dots (GQDs) grafted with gold nanoparticles (Au NPs) deposited on crystal facet engineered TiO2 (Ti). The effect of the Au NPs size on photoelectrochemical (PEC) water splitting performance was systematically investigated. It was found that the TiO2 with co‐exposed {001}‐{010} facet deposited with large particle size of Au NPs showed an enhancement in PEC performance, due to the localized surface plasmon resonance (LSPR). By contrast, the system containing Au NPs with smaller size retarded the transport rate of free electrons because of their high electron affinity. Interestingly, the hybrid catalyst (GQDs‐Aud40/Ti) delivered a considerable high current density (0.535 mA/cm2 at 1.23 V vs RHE), as compared to the pristine TiO2 (0.267 mA/cm2). This was due to the capability of GQDs in acting as an electron extractor, withdrawing hot electrons produced by Au NPs and inhibiting the charge recombination. Overall, this work demonstrated that the PEC water splitting performance of TiO2 based photo‐electrocatalyst can be synergistically enhanced by combining the plasmonic effect of Au NPs and electron extractor properties of GQDs.
An Unexpected C‐S Bond Transformation with High Chemoselectivity for the Synthesis of Aryl‐Benzyl Sulfones
Authors: Liu Teng , Shen Xianfu , Liu Zining , Shi Rong , Wei Wen , Xu Yanli , Cheng Feixiang 
Published: September 2021

AbstractIn this report, an unexpected C−S bond transformation involving a high chemoselectivity between sulfonylhydrazides and dibenzyl phosphite catalyzed by NaI under mild conditions has been developed. This alternative protocol could provide a metal‐free route to access a diverse aryl‐benzyl sulfones in good to excellent yields.
2‐Mercapto Benzoxazole Derivatives as Novel Leads: Urease Inhibition, In Vitro and In Silico Studies
Authors: Balogun Modinat M. , Shamim Shahbaz , Khan Khalid M. , Salar Uzma , Oladosu Ibrahim A. , Lateef Mehreen , Wadood Abdul , Taha Muhammad , Moronkola Dorcas O. , Rehman Ashfaq U. , Rahim Fazal , Perveen Shahnaz 
Published: September 2021

AbstractTwenty‐three benzoxazole derivatives were prepared through two‐step reaction strategy. The precursor, 2‐mercapto benzoxazole was synthesized by reacting 2‐amino phenol with carbon disulfide in the presence of potassium hydroxide. Then, 2‐mercapto benzoxazole was further reacted with substituted phenacyl/benzyl bromide to afford a range of substituted 2‐mercapto benzoxazole analogs. All compounds were characterized by different spectroscopic techniques including mass spectrometry and nuclear magnetic resonance spectroscopy, and investigated against urease enzyme. All analogs revealed good to moderate urease inhibition, ranging from IC50 = 17.50±0.10 to 42.50±0.44 μM. Few derivatives showed superior activity than thiourea (IC50=21.50±0.47 μM), standard inhibitor of urease enzyme. Structure‐activity relationship (SAR) revealed the crucial participation of various structural features in the inhibitory process. Compounds bearing methoxy and halogen substituents were found to show more potency as compared with other molecules. Molecular docking showed various interesting interactions established by molecules (ligand) with the active pocket of urease enzyme.
Nanomaterials as Nanofertilizers and Nanopesticides: An Overview
Authors: Okey‐Onyesolu Chinenye Faith , Hassanisaadi Mohadeseh , Bilal Muhammad , Barani Mahmood , Rahdar Abbas , Iqbal Javed , Kyzas George Z. 
Published: September 2021

AbstractNanotechnology has acquired increasing interest recently in agriculture and crop production for achieving proficient utilization of resources by developing nanodelivery systems for agrochemical products or sensors (for nutrient status or water). The development of new nanofertilizers provides a promising opportunity to improve plant mineral nutrition. According to the reports, nanostructured materials are more efficient than traditional fertilizers, with a site‐specific and controlled release of nutrients that not only increased the efficacy of plant uptake but also reduced negative environmental effects due to the loss of nutrients into the environmental matrices. In this section, we illustrate various kinds of novel nanostructured materials as promising carriers for nutrients such as nanoclays, carbon nanodots, carbon nanotubes, and nanofibers, hydroxyapatite nanoparticles, carbon‐based nanomaterials, and polymeric nanoparticles. Also, the impact of nanomaterials on pesticides is discussed. They play a great contribution to enhancing agricultural productivity involving for gradual release and proper pesticide dosage to aid pest control. Different nanomaterials used are discussed contributing to the reduction of the exposure of humans to pesticides.
Advanced design of cathodes and interlayers for high‐performance lithium‐selenium batteries
Authors: Dong Yanfeng , Lu Pengfei , Ding Yajun , Shi Haodong , Feng Xinliang , Wu Zhong‐Shuai 
Published: September 2021

AbstractLithium‐selenium (Li‐Se) batteries have attracted ever‐increasing attention owing to high volumetric capacity comparable to lithium‐sulfur batteries and excellent electronic conductivity of Se. However, unsatisfactory energy density and cycling life of Li‐Se batteries mainly caused by low utilization of Se and shuttle effect of polyselenides (PSes) seriously prevent their commercial applications. Herein, this work systematically reviews the recent advances of the state‐of‐the‐art cathodes and interlayers in high‐performance Li‐Se batteries. First, the fundamental chemistries of Li‐Se batteries are introduced in terms of various Se precursors and electrochemical behaviors. Second, the main strategies in cathodes and interlayers for addressing poor conductivity of Se and shuttle effects of PSes are summarized as three‐dimensional conductive skeletons for Se, physical confinement of Se, chemisorption and catalytic conversion of PSes, and free‐standing interlayers and interlayers on separators. Further, the synthesis strategies and enhanced electrochemical performance are specially exemplified to highlight the possible enlightenments for constructing advanced cathodes and interlayers. Finally, the future challenges and perspectives of advanced cathodes and interlayers in high‐performance Li‐Se batteries are briefly discussed.
When it is not primary progressive aphasia: A scoping review of spoken language impairment in other neurodegenerative dementias
Authors: Suárez‐González Aida , Cassani Alice , Gopalan Ragaviveka , Stott Joshua , Savage Sharon 
Published: September 2021

AbstractBackgroundProgressive difficulties with spoken language occur across the spectrum of degenerative dementia. When not a primary presenting and dominant symptom, language difficulties may be overlooked in favor of more prominent cognitive, behavior, or motor deficits. The aim of this scoping review is to examine the extent and nature of the research evidence describing (1) the spoken language impairments found in non‐language led dementias, (2) their impact on everyday living, and (3) the reported language interventions.MethodsWe searched PubMed, MEDLINE, OVID‐EMBASE, PsycINFO, and SpeechBITE using terms related to spoken language for the following dementia types: Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP), cortico‐basal syndrome (CBS), behavior variant frontotemporal dementia (bvFTD), early‐onset Alzheimer's disease (EOAD), posterior cortical atrophy (PCA), and motor neuron disease associated with FTD (MND+FTD). Risk of bias was assessed with the QualSyst tool.ResultsSeventy‐three eligible studies were included. A wide range of spoken language impairments were reported, involving both linguistic (e.g., syntactic processing) and other cognitive (e.g., sustained attention) underlying mechanisms. Although the severity of these deficits was scarcely reported, in some cases they manifested as non‐fluent, dynamic, and global aphasias. No papers in the review described either the impact of these language impairments on everyday living or language therapies to treat them.DiscussionThere is a need to understand better the level of disability produced by language impairment in people living with non–language‐led dementias. Our findings suggest three calls for action: (1) research studies should assess the clinical relevance of any spoken language deficits examined, (2) both linguistic and cognitive underlying mechanisms should be fully described (to inform the design of effective language and behavioral interventions), and (3) trials of language therapy should be conducted in those groups of individuals where significant language impairment is proved.
Complex gastroschisis: a new indication for fetal surgery?
Authors: Joyeux L. , Belfort M. A. , De Coppi P. , Basurto D. , Valenzuela I. , King A. , De Catte L. , Shamshirsaz A. A. , Deprest J. , Keswani S. G. 
Published: September 2021

ABSTRACTGastroschisis (GS) is a congenital abdominal wall defect, in which the bowel eviscerates from the abdominal cavity. It is a non‐lethal isolated anomaly and its pathogenesis is hypothesized to occur as a result of two hits: primary rupture of the ‘physiological’ umbilical hernia (congenital anomaly) followed by progressive damage of the eviscerated bowel (secondary injury). The second hit is thought to be caused by a combination of mesenteric ischemia from constriction in the abdominal wall defect and prolonged amniotic fluid exposure with resultant inflammatory damage, which eventually leads to bowel dysfunction and complications. GS can be classified as either simple or complex, with the latter being complicated by a combination of intestinal atresia, stenosis, perforation, volvulus and/or necrosis. Complex GS requires multiple neonatal surgeries and is associated with significantly greater postnatal morbidity and mortality than is simple GS. The intrauterine reduction of the eviscerated bowel before irreversible damage occurs and subsequent defect closure may diminish or potentially prevent the bowel damage and other fetal and neonatal complications associated with this condition. Serial prenatal amnioexchange has been studied in cases with GS as a potential intervention but never adopted because of its unproven benefit in terms of survival and bowel and lung function. We believe that recent advances in prenatal diagnosis and fetoscopic surgery justify reconsideration of the antenatal management of complex GS under the rubric of the criteria for fetal surgery established by the International Fetal Medicine and Surgery Society (IFMSS). Herein, we discuss how conditions for fetoscopic repair of complex GS might be favorable according to the IFMSS criteria, including an established natural history, an accurate prenatal diagnosis, absence of fully effective perinatal treatment due to prolonged need for neonatal intensive care, experimental evidence for fetoscopic repair and maternal and fetal safety of fetoscopy in expert fetal centers. Finally, we propose a research agenda that will help overcome barriers to progress and provide a pathway toward clinical implementation. © 2021 International Society of Ultrasound in Obstetrics and Gynecology.
Internationalization of Universities: 70 Years of Experience
Authors: Filippov Vladimir 
Published: September 2021

AbstractThe creation of the IAU 70 years ago was one of the consequences of evolving international life following the Second World War. This featured the evolution of organizations such as the United Nations, UNESCO, the Council of Europe and the European Union. In higher education, new international policies led to the internationalization of universities (Altbach, 2010). From the beginning, the IAU became one of the international platforms where universities exchanged experiences and built relations. In the acting strategy of IAU adopted in 2016, internationalization is one of the four priorities.
Promoting Values Together: Global Currency with Local Impact for Universities
Authors: Noorda Sijbolt , Lock David-John 
Published: September 2021

AbstractThe missions of the Magna Charta Observatory (MCO) and the International Association of Universities (IAU) have much in common. They both serve universities, are global in their reach but sensitive to local situations, and, fundamentally, they are based on values, values which have both global currency and local impact.
Mitigating Corruption in Higher Education
Authors: Denisova-Schmidt Elena 
Published: September 2021

AbstractThe lack of academic integrity, fraud, and other forms of unethical behaviour are problems that higher education faces in both developing and developed countries, at mass and elite universities, and public and private institutions. While academic misconduct is not new, massification, internationalization, privatization, digitalization, and commercialization have placed ethics higher on the agenda for many universities (Denisova-Schmidt and De Wit 2017; Denisova-Schmidt 2018, 2019; Bretag 2020).