bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissolution of delta phase in Ni-based superalloy during linear friction welding: integrated multiphysics computational process modelling
Authors: Okeke Saviour I. , Harrison Noel M. , Tong Mingming 
Published: June 2021

AbstractLinear friction welding (LFW) is an increasingly popular solid-state joining method for challenging applications such as integrated blade disk of aero-engines. However, the influence of friction-generated heat on the material microstructural evolution, material deformation and resultant mechanical performance of the manufactured components is not well understood. A novel integrated multiphysics computational modelling is presented for predicting the component-scale microstructural evolution of IN718 alloy during LFW. A modified time-temperature equivalence formulation was implemented for predicting the evolution of the δ phase, which was coupled with thermomechanical modelling of the LFW process. There is reasonably good agreement between the computational modelling results of this paper and the experimental results from the literature in terms of δ phase volume fraction and weld temperature. The integrated multiphysics computational modelling predicts the influence of process parameters on thermomechanical and microstructural processes of IN718 LFW. By systematically analysing the influence of 10 different LFW process parameter configurations, the friction pressure was identified as the most influential process parameter determining the extent of δ phase dissolution and weld temperature during LFW.
Galerkin approximation of holomorphic eigenvalue problems: weak T-coercivity and T-compatibility
Authors: Halla Martin 
Published: June 2021

AbstractWe consider Galerkin approximations of eigenvalue problems for holomorphic Fredholm operator functions for which the operators do not have the structure “coercive+compact”. In this case the regularity (in the vocabulary ofdiscrete approximation schemes) of Galerkin approximations is not unconditionally satisfied and the question of convergence is delicate. We report a technique to prove regularity of approximations which is applicable to a wide range of eigenvalue problems. The technique is based on the knowledge of a suitableTest function operator. In particular, we introduce the concepts of weak T-coercivity and T-compatibility and prove that for weakly T-coercive operators, T-compatibility of Galerkin approximations implies their regularity. Our framework can be successfully applied to analyze e.g. complex scaling/perfectly matched layer methods, problems involving sign-changing coefficients due to meta-materials and also (boundary element) approximations of Maxwell-type equations. We demonstrate the application of our framework to the Maxwell eigenvalue problem for a conductive material.
Evaluation of efficacy and toxicity of nivolumab combined with or without docetaxel in patients with advanced NSCLC
Authors: Wang Yang , Nie Jun , Dai Ling , Hu Weiheng , Zhang Jie , Chen Xiaoling , Ma Xiangjuan , Tian Guangming , Han Jindi , Han Sen , Wu Di , Long Jieran , Zhang Ziran , Fang Jian 
Published: June 2021

Abstract
Background
The combination of PD-1/PD-L1 inhibitor and chemotherapy has been clinically confirmed to be beneficial as the first-line treatment of patients with advanced NSCLC. This study aimed to assess the effect of nivolumab + docetaxel versus nivolumab monotherapy in patients with NSCLC after the failure of platinum doublet chemotherapy.

Materials and methods
The efficacy and toxicity of nivolumab + docetaxel combination therapy versus nivolumab monotherapy were compared in this retrospective study. Primary endpoint of the study was progression-free survival (PFS), and the secondary endpoints were objective response rate (ORR), overall survival (OS), and toxicity.

Results
Between November 2017 and December 2019, 77 patients were included in this study, with 58 patients in the nivolumab group and 19 in the nivolumab + docetaxel group. The median follow-up was 18 months, and the PFS was 8 months for patients receiving nivolumab + docetaxel and 2 months for those receiving nivolumab alone (p = 0.001), respectively. Nivolumab + docetaxel showed superior OS compared with nivolumab, with the median OS unreached versus 7 months (p = 0.011). Among patients without EGFR/ALK variation, compared to nivolumab monotherapy, nivolumab + docetaxel showed better PFS (p = 0.04) and OS (p  = 0.05). There was no significant difference in grade 3–4 adverse events (AEs) between the two groups (p = 0.253).

Conclusions
The combination of nivolumab and docetaxel demonstrated a meaningful improvement in progression-free survival and overall survival compared to nivolumab monotherapy, in patients with NSCLC after the failure of platinum doublet chemotherapy, irrespective of EGFR/ALK variation status.
Latitudinal variation in monthly-scale reproductive synchrony among Acropora coral assemblages in the Indo-Pacific
Authors: Bouwmeester Jessica , Edwards Alasdair J. , Guest James R. , Bauman Andrew G. , Berumen Michael L. , Baird Andrew H. 
Published: June 2021

AbstractEarly research into coral reproductive biology suggested that spawning synchrony was driven by variations in the amplitude of environmental variables that are correlated with latitude, with synchrony predicted to break down at lower latitudes. More recent research has revealed that synchronous spawning, both within and among species, is a feature of all speciose coral assemblages, including equatorial reefs. Nonetheless, considerable variation in reproductive synchrony exists among locations and the hypothesis that the extent of spawning synchrony is correlated with latitude has not been formally tested on a large scale. Here, we use data from 90 sites throughout the Indo-Pacific and a quantitative index of reproductive synchrony applied at a monthly scale to demonstrate that, despite considerable spatial and temporal variation, there is no correlation between latitude and reproductive synchrony. Considering the critical role that successful reproduction plays in the persistence and recovery of coral reefs, research is urgently needed to understand the drivers underpinning variation in reproductive synchrony.
Social isolation and psychosis: an investigation of social interactions and paranoia in daily life
Authors: Fett Anne-Kathrin J. , Hanssen Esther , Eemers Marlie , Peters Emmanuelle , Shergill Sukhi S. 
Published: June 2021

AbstractSocial isolation has been suggested to foster paranoia. Here we investigate whether social company (i.e., being alone vs. not) and its nature (i.e., stranger/distant vs. familiar other) affects paranoia differently depending on psychosis risk. Social interactions and paranoid thinking in daily life were investigated in 29 patients with clinically stable non-affective psychotic disorders, 20 first-degree relatives, and 26 controls (n = 75), using the experience sampling method (ESM). ESM was completed up to ten times daily for 1 week. Patients experienced marginally greater paranoia than relatives [b = 0.47, p = 0.08, 95% CI (− 0.06, 1.0)] and significantly greater paranoia than controls [b = 0.55, p = 0.03, 95% CI (0.5, 1.0)], but controls and relatives did not differ [b = 0.07, p = 0.78, 95% CI (− 0.47, 0.61)]. Patients were more often alone [68.5% vs. 44.8% and 56.2%, respectively, p = 0.057] and experienced greater paranoia when alone than when in company [b = 0.11, p = 0.016, 95% CI (0.02, 0.19)]. In relatives this was reversed [b = − 0.17, p < 0.001, 95% CI (− 0.28, − 0.07)] and in controls non-significant [b = − 0.02, p = 0.67, 95% CI (− 0.09, 0.06)]. The time-lagged association between being in social company and subsequent paranoia was non-significant and paranoia did not predict the likelihood of being in social company over time (both p’s = 0.68). All groups experienced greater paranoia in company of strangers/distant others than familiar others [X2(2) = 4.56, p = 0.03] and being with familiar others was associated with lower paranoia over time [X2(2) = 4.9, p = 0.03]. Patients are frequently alone. Importantly, social company appears to limit their paranoia, particularly when being with familiar people. The findings stress the importance of interventions that foster social engagement and ties with family and friends.
Systematic reviews in surgery—recommendations from the Study Center of the German Society of Surgery
Authors: Kalkum Eva , Klotz Rosa , Seide Svenja , Hüttner Felix J. , Kowalewski Karl-Friedrich , Nickel Felix , Khajeh Elias , Knebel Phillip , Diener Markus K. , Probst Pascal 
Published: June 2021

Abstract
Background
Systematic reviews are an important tool of evidence-based surgery. Surgical systematic reviews and trials, however, require a special methodological approach.

Purpose
This article provides recommendations for conducting state-of-the-art systematic reviews in surgery with or without meta-analysis.

Conclusions
For systematic reviews in surgery, MEDLINE (via PubMed), Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL) should be searched. Critical appraisal is at the core of every surgical systematic review, with information on blinding, industry involvement, surgical experience, and standardisation of surgical technique holding special importance. Due to clinical heterogeneity among surgical trials, the random-effects model should be used as a default. In the experience of the Study Center of the German Society of Surgery, adherence to these recommendations yields high-quality surgical systematic reviews.
Diaphragmatic herniation after esophagogastric surgery: systematic review and meta-analysis
Authors: Bona Davide , Lombardo Francesca , Matsushima Kazuhide , Cavalli Marta , Panizzo Valerio , Mendogni Paolo , Bonitta Gianluca , Campanelli Giampiero , Aiolfi Alberto 
Published: June 2021

Abstract
Introduction
The anatomy of the esophageal hiatus is altered during esophagogastric surgery with an increased risk of postoperative hiatus hernia (HH). The purpose of this article was to examine the current evidence on the surgical management and outcomes associated with HH after esophagogastric surgery for cancer.

Materials and methods
Systematic review and meta-analysis. Web of Science, PubMed, and EMBASE data sets were consulted.

Results
Twenty-seven studies were included for a total of 404 patients requiring surgical treatment for HH after esophagogastric surgery. The age of the patients ranged from 35 to 85 years, and the majority were males (82.3%). Abdominal pain, nausea/vomiting, and dyspnea were the commonly reported symptoms. An emergency repair was required in 51.5%, while a minimally invasive repair was performed in 48.5%. Simple suture cruroplasty and mesh reinforced repair were performed in 65% and 35% of patients, respectively. The duration between the index procedure and HH repair ranged from 3 to 144 months, with the majority (67%) occurring within 24 months. The estimated pooled prevalence rates of pulmonary complications, anastomotic leak, overall morbidity, and mortality were 14.1% (95% CI = 8.0–22.0%), 1.4% (95% CI = 0.8–2.2%), 35% (95% CI = 20.0–54.0%), and 5.0% (95% CI = 3.0–8.0%), respectively. The postoperative follow-up ranged from 1 to 110 months (mean = 24) and the pooled prevalence of HH recurrence was 16% (95% CI = 13.0–21.6%).

Conclusions
Current evidence reporting data for HH after esophagogastric surgery is narrow. The overall postoperative pulmonary complications, overall morbidity, and mortality are 14%, 35%, and 5%, respectively. Additional studies are required to define indications and treatment algorithm and evaluate the best technique for crural repair at the index operation in an attempt to minimize the risk of HH.
Consistent posets
Authors: Chajda Ivan , Länger Helmut 
Published: June 2021

AbstractWe introduce so-called consistent posets which are bounded posets with an antitone involution$$'$$′where the lower cones of$$x,x'$$x,x′and of$$y,y'$$y,y′coincide provided thatx, yare different from 0, 1 and, moreover, ifx, yare different from 0, then their lower cone is different from 0, too. We show that these posets can be represented by means of commutative meet-directoids with an antitone involution satisfying certain identities and implications. In the case of a finite distributive or strongly modular consistent poset, this poset can be converted into a residuated structure and hence it can serve as an algebraic semantics of a certain non-classical logic with unsharp conjunction and implication. Finally we show that the Dedekind–MacNeille completion of a consistent poset is a consistent lattice, i.e., a bounded lattice with an antitone involution satisfying the above-mentioned properties.
Clipping of unruptured cerebral aneurysms
Authors: Winter Fabian , Markert Celia M. , Krawagna Maximilian , Buchfelder Michael , Roessler Karl 
Published: June 2021

Summary
Background
The incidence of aneurysms is steadily increasing in older patients due to the aging population. This study compared radiological parameters as well as clinical outcomes between patients younger than 65 years and those over 65 years of age, with special respect to individual treatment options.

Methods
Retrospective data were obtained for patients with cerebral aneurysms at a single academic institution within a 7-year period. Data reviewed included admission protocols, patient charts, operating reports as well as outpatient clinic charts. Aneurysmal characteristics as well as surgical outcome were compared between older patients, defined as patients older than 65 years of age, and a control group of patients younger than 65 years of age. To evaluate and compare individual clinical characteristics various scores including the Hunt and Hess score, the Fisher score, and the Glasgow outcome scale were used.

Results
A total of 347 patients were included in the final analysis. The control group included 290 patients, while 57 patients were in the older patient group. Neither the Hunt and Hess scores nor Fisher scores were significantly correlated to patient age. The Glasgow outcome scale was significantly lower in the older group after clipping of ruptured aneurysms (p < 0.000) but not significantly different after clipping of unruptured aneurysms (p = 0.793).

Conclusion
Postoperative Glasgow outcome scale scores were not significantly different after clipping of unruptured cerebral aneurysms approximately 1 cm in diameter in older patients compared to the younger age group. Therefore, clipping of unruptured cerebral aneurysms may also be a valuable treatment option for older patients.
Comparative evaluation of WIMP and immersive natural finger interaction: a user study on CAD assembly modeling
Authors: Fechter Marius , Schleich Benjamin , Wartzack Sandro 
Published: June 2021

AbstractVirtual and augmented reality allows the utilization of natural user interfaces, such as realistic finger interaction, even for purposes that were previously dominated by the WIMP paradigm. This new form of interaction is particularly suitable for applications involving manipulation tasks in 3D space, such as CAD assembly modeling. The objective of this paper is to evaluate the suitability of natural interaction for CAD assembly modeling in virtual reality. An advantage of the natural interaction compared to the conventional operation by computer mouse would indicate development potential for user interfaces of current CAD applications. Our approach bases on two main elements. Firstly, a novel natural user interface for realistic finger interaction enables the user to interact with virtual objects similar to physical ones. Secondly, an algorithm automatically detects constraints between CAD components based solely on their geometry and spatial location. In order to prove the usability of the natural CAD assembly modeling approach in comparison with the assembly procedure in current WIMP operated CAD software, we present a comparative user study. Results show that the VR method including natural finger interaction significantly outperforms the desktop-based CAD application in terms of efficiency and ease of use.
Description and preliminary experience with Virtual Visit Assessment (ViVA) during the COVID-19 pandemic, a structured virtual management protocol for patients with multiple sclerosis
Authors: Bergamaschi Roberto , Tronconi Livio , Bosone Daniele , Mastretti Antonella , Jommi Laura , Bassano Marco Andrè , Turrini Renato , Benati Sara , Volpe Marco , Franzini Jean Marie , Allodi Silvia , Mallucci Giulia 
Published: June 2021

AbstractIn people with multiple sclerosis (PwMS), strict follow-up is essential. Telemedicine has the potential to overcome many of the difficulties in routine management. Herein, we present a structured protocol that can be used to remotely manage patients with MS, describing in detail the steps to be taken and exams needed at each stage. A working group was established which developed a tailored protocol that can be adapted to a variety of settings. The overall protocol consisted of 5 phases: enrolment, document sharing phase, pre-evaluation, virtual visit, and post-visit phase, which was divided into 14 individual steps. As of October 2020, 25 virtual visits have been carried out, all via Skype. The patient’s caregiver was present during visits and had an active role. The average duration of the virtual visit was 24 min, and that of the pre-visit and post-visit were around 15 min each. Overall satisfaction as rated by physicians was considered high (8.0 ± 0.5). Using the system usability scale (SUS), patients also favorably rated the virtual visit (96.6 ± 6.1). In 20% of cases, the virtual visit was not sufficient to provide adequate information and an in-person clinical visit was recommended. The described protocol has the potential to provide benefits for the healthcare system as well as patients and their caregivers both during and beyond COVID-19 pandemic.
Combining regional to local restoration goals in the Brazilian Atlantic forest
Authors: Lemos Cassia M.G. , Andrade Pedro R. , Rodrigues Ricardo R. , Hissa Leticia , Aguiar Ana P. D. 
Published: June 2021

AbstractTo achieve regional and international large-scale restoration goals with minimum costs, several restoration commitments rely on natural regeneration, a passive and inexpensive strategy. However, natural regeneration potential may vary within the landscape, mainly due to its historical context. In this work, we use spatially explicit restoration scenarios to explore how and where, within a given region, multiple restoration commitments could be combined to achieve cost-effectiveness outcomes. Our goal is to facilitate the elaboration of forest restoration plans at the regional level, taking into consideration the costs for active and passive restoration methods. The approach includes (1) a statistical analysis to estimate the natural regeneration potential for a given area based on alternative sets of biophysical, land cover, and/or socioeconomic factors and (2) the use of a land change allocation model to explore the cost-effectiveness of combining multiple restoration commitments in a given area through alternative scenarios. We test our approach in a strategic region in the Brazilian Atlantic Forest Biome, the Paraiba Valley in São Paulo State. Using the available data for 2011, calibrated for 2015, we build alternative scenarios for allocating natural regeneration until 2025. Our models indicate that the natural regeneration potential of the region is actually very low, and the cost-effectiveness outcomes are similar for all scenarios. We believe our approach can be used to support the regional-level decision-making about the implementation of multiple commitments aiming at the same target area. It can also be combined with other approaches for more refined analysis (e.g., optimization models).
Multispecialty Enterprise Imaging Workgroup Consensus on Interactive Multimedia Reporting Current State and Road to the Future: HIMSS-SIIM Collaborative White Paper
Authors: Roth Christopher J. , Clunie David A. , Vining David J. , Berkowitz Seth J. , Berlin Alejandro , Bissonnette Jean-Pierre , Clark Shawn D. , Cornish Toby C. , Eid Monief , Gaskin Cree M. , Goel Alexander K. , Jacobs Genevieve C. , Kwan David , Luviano Damien M. , McBee Morgan P. , Miller Kelly , Hafiz Abdul Moiz , Obcemea Ceferino , Parwani Anil V. , Rotemberg Veronica , Silver Elliot L. , Storm Erik S. , Tcheng James E. , Thullner Karen S. , Folio Les R. 
Published: June 2021

AbstractDiagnostic and evidential static image, video clip, and sound multimedia are captured during routine clinical care in cardiology, dermatology, ophthalmology, pathology, physiatry, radiation oncology, radiology, endoscopic procedural specialties, and other medical disciplines. Providers typically describe the multimedia findings in contemporaneous electronic health record clinical notes or associate a textual interpretative report. Visual communication aids commonly used to connect, synthesize, and supplement multimedia and descriptive text outside medicine remain technically challenging to integrate into patient care. Such beneficial interactive elements may include hyperlinks between text, multimedia elements, alphanumeric and geometric annotations, tables, graphs, timelines, diagrams, anatomic maps, and hyperlinks to external educational references that patients or provider consumers may find valuable. This HIMSS-SIIM Enterprise Imaging Community workgroup white paper outlines the current and desired clinical future state of interactive multimedia reporting (IMR). The workgroup adopted a consensus definition of IMR as “interactive medical documentation that combines clinical images, videos, sound, imaging metadata, and/or image annotations with text, typographic emphases, tables, graphs, event timelines, anatomic maps, hyperlinks, and/or educational resources to optimize communication between medical professionals, and between medical professionals and their patients.” This white paper also serves as a precursor for future efforts toward solving technical issues impeding routine interactive multimedia report creation and ingestion into electronic health records.
Mind the Gap
Authors: Smid Jeroen 
Published: June 2021

AbstractIn debates about the metaphysics of material objects examples of colocated objects are commonly taken to be examples of coincidence too. But the argument that colocation is best understood as involving coincidence is never spelled out. This paper shows under what conditions colocation entails coincidence and argues that the entailment depends on a principle that actually rules out certain forms of colocation. This undermines the argument from colocation to coincidence.
Guidance in computer-supported collaborative inquiry learning: Capturing aspects of affect and teacher support in science classrooms
Authors: Pietarinen Tarja , Palonen Tuire , Vauras Marja 
Published: June 2021

AbstractTechnology-enhanced collaborative inquiry learning has gained a firm position in curricula across disciplines and educational settings and has become particularly pervasive in science classrooms. However, understanding of the teacher’s role in this context is limited. This study addresses the real-time shifts in focus and distribution of teachers’ guidance and support of different student groups during in-person computer-supported collaborative inquiry learning in science classrooms. Teachers’ self-perceptions of their guidance and affect were supplemented with students’ self-reported affect. A mixed-methods approach using video analyses and questionnaire data revealed differences between teacher guidance and support associated with teacher perceptions and group outcomes. Groups’ prior science competence was not found to have an effect on teacher guidance and support, rather the teachers guided the groups they perceived as motivated and willing to collaborate. Teacher affect was compounded by student affect, suggesting that consideration of the reciprocal perceptions of teachers and students is necessary in order to understand the teachers’ role in collaborative learning.