bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of histopathological results of minor salivary gland biopsies in patients with the diagnosis of Sjögren’s syndrome
Authors: Erkılınç Gamze , Doğru Atalay , Arslan Yaşar , Burak Öz Rıza , Karahan Nermin , Şahin Mehmet , Metin Çiriş İbrahim 
Published: December 2021

Objectives: This study aims to evaluate which of the histomorphological criteria defined in labial salivary gland biopsy are more valuable in diagnosing Sjögren’s syndrome (SS) and to examine its correlation with clinical and laboratory findings.
Patients and methods: Between January 2005 and January 2019, a total of 927 patients (104 males, 823 females; mean age: 51 years; range, 19 to 85 years) who underwent minor salivary gland biopsies with the suspicion of SS were retrospectively analyzed. The American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) 2016 classification criteria were used for the classification of SS. We evaluated salivary gland biopsies histomorphologically for the presence and number of lymphocytic focus, as well as chronicity findings (acinar atrophy, ductal dilatation, fibrosis), the presence of lymphocytic infiltration, distribution, localization, ectopic germinal center, and mast cell count. The presence of accompanying diseases, clinical and laboratory findings including age, sex, the presence of dry eye and mouth, and autoantibodies for discriminating SS were noted. Histomorphologically, salivary gland biopsy which fulfilled the adequacy criteria for glandular tissue were compared with the other criteria used to diagnose SS.
Results: Strong chronicity and diffuse lymphocytic infiltration were significantly higher in the SS group compared to the non-SS group (p<0.001). Lymphocytic focus score >1 was significantly higher in the SS group compared to the non-SS group (p<0.001). Strong chronicity, acinar atrophy, andductal dilatation were significantly higher in the SS group compared to the non-SS group (p<0.001).
Conclusion: More than one lymphocytic focus is the most valuable finding in diagnosing SS. However, it should be kept in mind that, in cases of SS, ductal dilatation, acinar atrophy, and chronicity may be present without lymphocytic infiltration.
The comparison of effects of balneotherapy, water-based and land-based exercises on disease activity, symptoms, sleep quality, quality of life and serum sclerostin level in patients with ankylosing spondylitis: A prospective, randomized study
Authors: Bestaş Ersin , Dündar Ümit , Köken Tülay , Koca Buğra , Yeşil Hilal 
Published: December 2021

Objectives:This study aims to compare the effects of balneotherapy, water-based exercise (WBE), and land-based exercise (LBE) on disease activity, symptoms, sleep quality, quality of life, and serum sclerostin level (SSL) in patients with ankylosing spondylitis (AS).Patients and methods:Between January 2019 and January 2020, a total of 60 patients (35 males, 25 females; mean age: 40.9±11.2 years; range, 18 to 55 years) who were diagnosed with AS were randomly divided into the balneotherapy (n=20), WBE (n=20), and LBE (n=20) groups (20 sessions of treatment in groups of five to six patients). The patients were evaluated before treatment and at 4 and 12 weeks using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Ankylosing Spondylitis Disease Activity Score-C-reactive protein (ASDAS-CRP), Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), Ankylosing Spondylitis Quality of Life (ASQoL) Scale, Fatigue Severity Scale (FSS), and Pittsburg Sleep Quality Index (PSQI), and SSL were measured.Results:Statistically significant improvements in the BASDAI, BASFI, MASES, BASMI, ASQoL, FSS, and ASDAS-CRP scores were observed in all groups at 4 and 12 weeks of follow-up (p<0.05). A significant improvement in sleep latency was seen in the balneotherapy and WBE groups. Changes in SSL were not statistically significant in any group (p>0.05).Conclusion:Balneotherapy, WBE, and LBE are effective in the treatment of AS, and the beneficial effects may last for at least 12 weeks.
Transition readiness in adolescents with juvenile idiopathic arthritis and their parents: Our single-center experience
Authors: Lazarević Dragana , Đorđević Stefan , Novaković Dušica , Zečević Maja , Sušić Gordana 
Published: December 2021

Objectives: We aimed to identify characteristics of juvenile idiopathic arthritis (JIA) patients associated with good self-management skills in the transition readiness process and to investigate the readiness of JIA patients and their families for the transition into the adult healthcare system.
Patients and methods: Between March 2021 and June 2021, a total of 44 JIA patients (9 males, 35 females; median age: 15.1 years; range, 12.3 to 19.3 years) admitted to the pediatric rheumatology outpatient and inpatient clinics and their parents were included. Transition Readiness Assessment Questionnaire (TRAQ) was cross-culturally adapted. The TRAQ was administered to all JIA patients and their parents at one point. Demographic and clinical data were collected.
Results: Fourteen (31.8%) of 44 JIA patients had a concomitant disease, while 10 (22.7%) of them had uveitis. Eleven (25%) of them had a family history of autoimmune diseases. In total, 21 (47.7%) of JIA patients were receiving biologics. There was a strong correlation between older age and total TRAQ scores among patients (ρ=0.799, p<0.001) and a moderate correlation between older patient age and total TRAQ scores among parents (ρ=0.522, p<0.001). Patient and parent total TRAQ scores were strongly correlated (ρ=0.653, p<0.001). There was no significant association of JIA patient characteristics (JIA disease subtypes, disease duration, gender, concomitant diseases, uveitis, family history of autoimmune diseases, number of hospitalizations, and treatment with biologics) with TRAQ scores and JIA patients' and parents' readiness for transition.
Conclusion: Transition readiness of JIA patients increases with advancing age. There is no significant difference between transition readiness for JIA patients and their parents.
Adult Still's disease: New horizons
Authors: Nasonov E. L. , Feist E. 
Published: December 2021

Still's disease in children (systemic juvenile idiopathic arthritis - JIA) and adult Still's disease (ASD) are considered as systemic autoinflammatory diseases of unknown etiology, which are based on similar immunopathogenetic mechanisms associated with genetically determined disorders of the mechanisms of innate immunity. ASD was first described 50 years ago by the English rheumatologist Eric George Lapthorne Bywaters. The molecular basis of ASD immunopathogenesis is the activation of innate immunity associated with NLRP3 inflammasome-dependent mechanisms of inflammation, characterized by the overproduction of “pro-inflammatory” cytokines - interleukin (IL) 1 and IL-18, inducing the synthesis of other proinflammatory inflammatory mediators. A review of new data concerning the mechanisms of immunopathology, clinical polymorphism, laboratory biomarkers and the possibilities of ASD pharmacotherapy is presented.Particular attention is paid to the prospects for the use of monoclonal antibodies to IL-1β - canakinumab. The problems associated with the generality of clinical and laboratory disorders, pathogenetic mechanisms and pharmacotherapy of ASD and coronavirus disease 2019 (COVID-19) are considered.
The effect of therapy on subclinical atherosclerosis of the carotid arteries in patients with calcium pyrophosphate crystal deposition disease and osteoarthritis (pilot study)
Authors: Eliseev M. S. , Zhelyabina O. V. , Chikina M. N. , Markelova E. I. , Kirillova I. G. , Korsakova Yu. O. , Kobriseva A. A. 
Published: December 2021

Endothelial dysfunction associated with chronic microcrystalline inflammation plays a role in the progression of atherosclerosis in calcium pyrophosphate crystal deposition diseases (CPPD).The aim of the study was to assess the dynamics of the development of atherosclerosis based on changes in the thickness of the intima-media complex (ICIM) of the carotid arteries (CA) in patients with CPPD receiving long-term anti-inflammatory therapy (colchicine, methotrexate, hydroxychloroquine).Materials and methods. 26 patients with CPPD and 26 patients with osteoarthritis aged over 18 years old were included. Exclusion criteria: age >65 years; presence of cardiovascular diseases. The blood lipid spectrum, hs-CRP level, anthropometric parameters were determined for all, and Doppler ultrasound ultrasonography of the carotid arteries (CA) was performed. Patients were followed up for not <6 months, assessed ICIM CA at 1 visit, then patients with CPPD, at the discretion of the attending physician, were prescribed methotrexate at a dose of 15 mg per week, hydroxychloroquine 200 mg 1 time per day or colchicine 0.5 mg 2 times a day. Patients could take NSAIDs if they were in pain. The SCORE index has been calculated for everyone.Results. Initially, ICIM values did not differ in patients with CPPD and OA. Initially, ICIM>0.9 mm were detected in 11 of 22 (50%) patients with CPPD and in OA in 8 of 19 (42%) (p=0.39). In dynamics, patients with CPPD revealed a decrease in the number of patients with ICIM>0.9 mm from 42 to 18%. At the same time, in 8 patients with CPPD, ICIM>0.9 mm was combined with a CRP level >0.2 mg/l. Out of 22 patients with CPPD, 14 (64%) patients showed a decrease in the mean values of ICIM, in 2 (9%) patients - an increase, in 5 patients the mean values of ICIM did not change. After 6 months of therapy, out of 11 patients with CPPD with ICIM >0.9 mm, after 6 months of therapy, in 7 cases there was a decrease in the indicator less than the specified value, in 5 of them a decrease in serum CRP level <2 mg/l was recorded. In patients with CPPD, the serum CRP level significantly decreased; in patients with OA, it did not change. Out of 19 patients with OA, 9 (47%) patients showed an increase in the mean ICIM over time, while the rest did not change. In those treated with hydroxychloroquine, a decrease in the mean ICIM parameters was observed in 5 out of 6 (83%) patients, colchicine - in 6 out of 9 (67%) patients, methotrexate - in 4 out of 7 (57%) patients.With CPPD, the result of therapy with colchicine, methotrexate and hydroxychloroquine in relation to the development of the initial signs of atherosclerosis according to Doppler ultrasound ultrasonography of CA can be realized based on the presence of chronic inflammation.
Progression of sacroiliitis in men and women according to the cohort of early axial spondyloarthritis (CORSAR) over 3 years of follow-up
Authors: Timokhina D. G. , Dubinina T. V. , Demina A. B. , Krichevskaya O. A. , Erdes Sh. F. 
Published: December 2021

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease with predominant involvement of the sacroiliac joints (SIJ) and/or the spine. Despite the fact that the prevalence of axSpA is almost the same in men and women, there is evidence of a delay in diagnosis and a more severe course of the disease in females. The available reports on the progression of structural changes in the SIJ in men and women with early axSpA are contradictory. Meanwhile, the analysis of radiographic progression in the SIJ has fundamental importance both for timely diagnosis and for assessing the effectiveness of therapy in axSpA. Such studies have not yet been carried out in the Russian Federation.Objective: to assess the radiographic progression of sacroiliitis (SI) over 3 years in men and women with early axSpA.Material and methods. The study included patients from the cohort of early axSpA CORSAR, formed at the V.A. Nasonova Research Institute of Rheumatology. Currently, it includes 175 patients with axSpA. We analyzed the data of 64 patients, followed for at least 3 years. To assess the radiographic progression of the disease at baseline and after 3 years, the sum of X-ray stages of SI in the left and right SIJ was determined (the total stage of SI). Progression was assessed by the change in the total stage of SI in the right and left SIJ (0-8) during the observation period. We also calculated the proportion of patients with deterioration (increase in the total stage of SI by at least 1 stage), with improvement (decrease in the total stage of SI by at least 1 stage) and without progression. In order to fully exclude the error in measuring the radiographic progression of SI, we counted patients with “net” progression, that is, the proportion of patients with improvement was subtracted from the proportion of patients with deterioration.Results. Among 64 patients with early axSpA, there were 37 (57.8%) men and 27 (42.2%) women. For 3 years, the median of the total stage SI in men was 0 [0; 1], in women - 0 [0; 2] (p>0.05). When assessing the progression of the total stage SI over 3 years, no significant differences were found between the number of men and women with improvement, with deterioration, “net” progression and without progression. Men with early axSpA showed a higher level of C-reactive protein (CRP) at baseline, women had higher BASDAI and ASDAS CRP values after 3 years. In 8% of patients, there was a regression of X-ray signs of SI.Conclusion. The radiographic progression of SI in patients with early axSpA does not depend on gender and disease activity. In some patients with early axSpA, reverse development of structural damage to the SIJ is possible.
The effect of late diagnosis on survival and risk of vascular complications in Takayasu's arteritis patients
Authors: Borodina I. E. , Popov A. A. , Shardina L. A. 
Published: December 2021

Aim. To assess the effect of late diagnosis on survival and risk of vascular complications in Takayasu's arteritis (TA) patients. Methods. 183 patients with TA who were treated at the Sverdlovsk Regional Clinical Hospital No. 1 during the period from 01.01.1979 to 31.04.2018 were examined. There were 139 women and 44 men included, median age at the time of diagnosis being 35 [24; 44] years in females and 34 [26.5; 42] years in males and a median interval from the first symptoms onset to the diagnosis of 3 [1; 7] and 4 [1.5; 8] years respectively. The diagnosis of TA met the ACR criteria (1990).Results. During the follow-up period, 31 deaths were observed (18 in males and 13 in females). The median age of death for women was 36 [32-44] years, for men - 50 [40-57] years. Cardiovascular complications were recorded in 72 patients (27 men and 45 women). Vascular complications and namely acute cerebrovascular accident observed in 31 (43%) patients, including ischemic stroke in 24 (35%), transient ischemic attack in 3 (3%) and hemorrhagic stroke in 4 (6%) were the most frequent. Arterial thromboses were registered in 32 (44%) cases. In 162 (88.5%) patients, the diagnosis was established more than six months after the appearance of the first symptoms.At the primary physician visit in 71 (39%) patients, the initial diagnosis was erroneous. The most common symptoms they had were regarded as a manifestation of arterial hypertension (in 18% cases). 4 years or more interval from the onset of TA symptoms to diagnosis was associated with a significant cardiovascular events odds increase (OR=1.8; 95% CI: 1.07-3.34) and premature death by the 5th year of follow-up (OR=2.9; 95% CI: 1,27-6,55).Conclusion. In the retrospective TA cohort setting, late diagnosis verification and delayed treatment initiation were associated with an increased risk of premature death and severe vascular complications, described earlier in other samplings. Timely diagnosis and as early as possible appropriate treatment administration can prevent the disease progression and disabling complications occurrence.
The Influence of Interpersonal Communication, Universal-Diverse Orientation (UDO), and Self-Efficacy on the Quality of Administrative Services at State University of Jakarta
Authors: Yusuf Ifatuhoriah , Purwana Dedi , Buchdadi Agung Dharmawan 
Published: December 2021

This study aims to determine the direct effect of interpersonal communication, universal-diverse orientation (UDO), and self-efficacy on the quality of administrative services, as well as to determine the indirect effect of interpersonal communication and universal-diverse orientation (UDO) through self-efficacy on the quality of administrative services at State University of Jakarta. The research used was a survey with a causal design. The number of sample respondents was determined as 178 employees, the sampling technique was carried out by simple random (sample random sampling) from 230 employees of the State University of Jakarta. The results of this study indicate that; (1). There is a positive direct effect of Interpersonal Communication on the Quality of Academic Services, (2). There is a positive direct influence Universal-Diverse Orientation (UDO) on the Quality of Academic Services, (3). There is a positive direct effect of Self Efficacy on Academic Service Quality., (4) There is a positive direct influence of Interpersonal Communication on Self Efficacy, (5) There is a positive direct influence of Universal-Diverse Orientation (UDO) on Self Efficacy. The novelty in this research is that research conducted at this time is research looking at several variations of variables such as the influence of interpersonal communication, universal-diverse orientation (UDO), and self-efficacy on the quality of administrative services and quality variables as independent variables.
Trabajo y Aprendizaje Colaborativo en la Universidad. Aproximaciones en Pandemia
Authors: Ticona Contreras Jorge Giancarlo , Medina Sandoval Rosa Julia , Romaní Bazán Blanca Sofía , Criado Davila Yvette Vanessa 
Published: December 2021

La actual crisis mundial sanitaria, ha afectado a diversos sectores de la sociedad, siendo uno de ellos, el educativo. Dentro de los cambios más resaltantes se encuentra el cambio de clases presenciales a clases remotas, surgiendo de esta manera la necesidad del aprendizaje colaborativo de los estudiantes en instituciones educativas, como la universidad. Se concluyó la trascendencia del trabajo en equipo para lograr el aprendizaje colaborativo, y con ello, las competencias como la identidad, la comunicación, la ejecución, y la regulación, necesarias para la vida profesional.
Otra conclusión, fue que el uso de herramientas para desarrollar el aprendizaje colaborativo, como el foro que permite la interacción autónoma y solucionar problemas; los wikis que permiten la construcción de textos en línea y el monitoreo de parte del docente y de sus propios compañeros. Además, los chats favorecen la interacción en tiempo real, y el blog permite que los estudiantes puedan interactuar, organizar sus comentarios, favoreciendo el aprendizaje activo.
El paradigma de gestión de las MYPES textiles del emporio comercial Gamarra y las estrategias empresariales para afrontar la competencia mundial
Authors: Puell Palacios Juan , Gamonal Montoya José Alberto , Landa Rojas Manuel Jesús 
Published: December 2021

El conocimiento administrativo es hoy en día un recurso invaluable. La exigencia social y organizacional de una administración eficiente, es el gran reto del presente siglo. No sólo por competitividad, sino por motivos de sobrevivencia y de desarrollo con equilibrio.
La visión del futuro, es la incertidumbre, la complejidad y el dinamismo como condiciones permanentes en la gestión de empresas. Se trata pues, de encarar el problema de la gestión empresarial con una nueva perspectiva y sustentar en ella un renovado perfil gerencial, considerando el liderazgo como la arista principal, y cuyas condiciones es ser proactivo y no reactivo, imaginativo y creativo más que pragmático, y sobre todo, tener una visión sustentada en la ética.
En este trabajo de investigación se parte de la premisa: ¿Qué paradigma de gestión utilizan las Mypes que les pueda permitir enfrentar la competencia mundial, en un escenario globalizado con presencia de los tratados de libre comercio suscrito por el Perú, en donde será necesario aplicar una nueva gerencia, con habilidades creativas, de comunicación, de interrelación, identificado con los valores propios de la modernidad (competitividad, innovación, excelencia), con una gran visión y sobre todo con un propio y autentico estilo de liderazgo.
Corrupción y contratación de personal en el sector educación. Sistematización de referencias
Authors: Levano Arcos María del Carmen , Mendivil Arbieto Ruth Noemi , Villarroel Ayala Graciela Nieves 
Published: December 2021

La corrupción está presente en los diferentes sectores de la Administración Pública, el sector Educación no es la excepción, un aspecto en donde se percibe es en el tema de las contrataciones de personal, sea directivo, docente o administrativos.
La finalidad de este estudio reside en realizar una revisión bibliográfica que aborde la contratación de personal como factor en el desempeño de los docentes en las diferentes etapas educativas, para dar solución a esta preocupación del ámbito educativo. Se realizó una revisión sistemática en Bases de Datos EBSCO, PROQUEST, SCOPUS de artículos científicos del período comprendido entre 2018 a 2021, de acuerdo a la Matriz PRISMA, tomando en cuenta criterios de inclusión: texto completo, originales en español o inglés, revisión de expertos, investigaciones cuantitativas, se excluyeron a los que eran similares, a los que trataban el tema de contratación de personal. La búsqueda se llevó a cabo utilizando las ecuaciones (Corrupción AND Contratación de personal) OR (corrupción AND contratación de personal directivo) OR (Corrupción AND contratación de personal docente) se incluyeron en total 60 artículos. Se encontró relación significativa entre corrupción y contratación de personal. Se hace necesario realizar más estudios para profundizar lo presentado.
Pemanfaatan Penggunaan Lingkungan Alam Sekitar Sebagai Media Pendukung Pembelajaran IPA di MI/SD
Authors: Mutiara Mutiara 
Published: December 2021

Lingkungan alam merupakan salah satu ciri yang dikembangkan di sekolah sesuai dengan kebijakan Kementerian Pendidikan Nasional. Maka dari itu, materi dasar pembahasan kepedulian lingkungan terdapat dalaam kurikulum penedidikan, tersaji pada komponen materi pembelajaran di bidang studi IPA tiap jenjang Pendidikan. Pembelajaran pada pada kelas sering dipercaya menjadi hal yg membosankan, hal ini adalah galat satu penyebab rendahnyamotivasi & rendahnya output belajar bagi siswa. Untuk mengatasi permasalahan tersebut,peneliti memanfaatkan lingkungan alam sekitar menjadi media pendukung guna menaikkan hasil belajar siswa. Dengan harapan dari pembelajaran berbasis lingkungan dapat lebih menysukuri karunia Tuhan atas alam semesta ini, dengan cara selalu menjaga, memanfatakan, serta melestarikan untuk generasi penerus. Tujuan dari penelitian ini, yaitu untuk meningkatnya motivasi belajar siswa, siswa lebih inovatif dan kreatif, dapat mengetahui bagaimana proses pembelajaran dan hasil belajar peserta didik dalam memanfaatkan lingkungan sekitar, menjaga dan melestarikan kekayaan alam sekitar, guna untuk kehidupan yang lebih baik di masa yang akan datang. Pada Penelitian ini menggunakan metode Kajian Pustaka dengan berbagai sumber rujukan yang berfokuskan pada siswa untuk mengenal lingkungan setikar dalam pembelajaran IPA. Hasil Penelitian ini Pemanfaatan Penggunaan Lingkungan Alam Sekitar Sebagai Media Pendukung Pembelajaran IPA berperan penting dalam KBM terbukti siswa lebih memahami materi secara fakta dan hasil belajar lebih maksimal.