bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Structural Performance of Automated Multi-Depth Shuttle Warehouses (Amsws) Under Low-to-Moderate Seismic Actions
Authors: Kondratenko Aleksei , Kanyilmaz Alper , Castiglioni Carlo Andrea , Morelli Francesco , Kohrangi Mohsen 
Published: March 2021

Abstract
Automated Multi-Depth Shuttle Warehouses (AMSWs) are compact storage systems that provide a large surface occupation and therefore maximum storage density. AMSWs represent the future of storage technology, providing substantial savings in terms of cost, space, and energy with respect to traditional warehouses. Currently, designers refer to the standard building codes for the seismic design of AMSWs. Since structural characteristics of AMSWs are considerably different from the steel structures of typical buildings, this current approach used by designers is questionable in terms of safety and efficiency. In this article, the behavior of 5 AMSW structures has been studied performing 150 time-history analyses by direct integration including P-Delta effects. Demand/capacity ratios calculated for each element showed the dominance of the brittle failure mechanism in AMSWs subjected to low-to-moderate seismic actions. These mechanisms mainly took place in upright columns and their base connections prior to the activation of ductile energy dissipation mechanisms of the structure. Based on the results, further improvements have been recommended for the future design provisions, which may lead to a safer seismic design of AMSWs.
Prevalence of Diabetic Retinopathy and Risk Factors Among Diabetic Patients at University of Gondar Tertiary Eye Care and Training Center, North-West Ethiopia.&nbsp;
Authors: Ejigu Tesfahun , Tsegaw Asmere 
Published: March 2021

Abstract
Purpose: Diabetic retinopathy (DR) is one of the most serious complications of diabetes mellitus (DM). It is the most common cause of blindness among the working age group in the developed world and the fifth leading cause of global blindness. In Sub-Saharan Africa, 2.8% of all blindness is caused by DR. Studies addressing the patterns of DR and associated factors are scarce in Ethiopia. The objective of this study was to determine the Prevalence and associated factors of DR among DM patients attending University of Gondar (UOG), Tertiary Eye Care and Training center.Patients and methods: A cross-sectional study was carried out from March 2019 to February 2020 involving all consecutive diabetes patients who visited the center during the study period. Data were collected using a semi-structured questionnaire and data extraction check list, and entered into SPSS version 20 and analyzed. Univariate and multivariate logistic regression analysis were done to identify predictors of DR. Statistical significance was determined with 95% confidence interval using odds ratio and p-values.Results: A total of 225 DM patients with mean age of 55.4 ± 13.5 years were studied, of whom 95 (42.2%) had DR. Duration of diabetes ≥ 6 years (AOR= 2.91: 95%CI; 1.01-8.35) and baseline age < 60 years (AOR= 3.2: 95%CI; 1.19 - 8.63) were significantly associated with DR. Diabetic retinopathy was significantly associated with the form of therapy. Those on insulin (p=0.025), and oral hypoglycemic agents (OHA) with insulin combination (p=0.014) had statistically significantly associated with development of DR. Patients with systolic blood pressure of <140 mmHg were 3.6 times (AOR=0.28:95%CI:0.09-0.82) less likely to have DR. A majority of patients had Non-proliferative DR (NPDR) without diabetic macular edema (DME) (34.2%). DME and proliferative DR (PDR) were seen in 5.7% and 3.6% of the patients respectively. Vision threatening DR (VTDR) was seen in 10.7% of patients. There was significant association between age <60 years and VTDR (AOR=4.19: 95%CI; 1.23-14.35).Conclusion: The prevalence of DR among our study patients was very high. Longer duration of diabetes, higher systolic blood pressure, baseline age < 60 years, use of insulin alone and use of combination of insulin with OHA were independently associated with DR. Health education; early screening and treatment are recommended.
Down-regulation of LAMP3 inhibits the proliferation and migration of HSCC
Authors: Qiu Xiaoxia , Li Juanjuan , Yang Keke , Jiang Song , Yin Yong , Bian Longjun , Huang Xiaorong , Sun Yi , Zhang Zhenxin 
Published: March 2021

Abstract
BackgroundLysosomal-associated membrane glycoprotein 3 (LAMP3) has been shown to be highly expressed in various types of tumors. It is associated with their poor prognosis, proliferation, invasion, and metastasis, respectively. However, the role of LAMP3 in hypopharyngeal squamous cell carcinoma (HSCC) is unclear.ObjectiveThis article aims to investigate the role of LAMP3 in the proliferation and metastasis of HSCC.MethodDetection of the expression of LAMP3 in clinical HSCC and paired adjacent healthy tissue samples by using immunohistochemistry. Furthermore, LAMP3 was knocked out of the HSCC cell line, FaDu, using a lentivirus vector and the in vitro biological effects of LAMP3 knockdown in FaDu cells were studied.ResultsImmunohistochemistry results showed that LAMP3 was highly expressed in HSCC. Additionally, it was verified at the mRNA and protein levels that lentiviral transduction effectively down-regulated the expression of LAMP3 in FaDu cells. Cell colony formation assays and CCK8 proliferation assays showed that down-regulation of LAMP3 on FaDu cells inhibited cell proliferation and growth rate. Wound healing experiments and transwell experiments showed that significant down-regulation of LAMP3 on FaDu cells inhibited cell migration.ConclusionCollectively, our results suggest that LAMP3 is a useful therapeutic target for the treatment of hypopharyngeal cancer.
Monitoring and analysis of low-voltage network with smart grid architecture model by developing use cases
Authors: Kumar Haresh , Kumar Jagdesh , Devi Jherna 
Published: March 2021

Abstract
The objective of this paper is to show the characteristics of smart meters enabling to monitor and analyze the low-voltage (LV) network. This is achieved by developing use cases, where power quality and outage data are transferred from smart meters through distribution network to the control center. To visualize the monitoring process of LV network, the use cases are mapped into smart grid architecture model. The paper proposes a solution to analyze the LV network interruption and power quality problems (over-voltage, under-voltage, voltage sags, and swells). Thus, this paper provides a smart platform for monitoring LV network.
Impact of temperature on chlorination strategies for mussel control at water treatment plants
Authors: Alonzo-Moya Carlos , Lake-Thompson Ian , Hurtado Alonso , Hofmann Ron 
Published: March 2021

Abstract
Drinking water treatment plants in the Great Lakes often protect their intake structures against dreissenid biofouling by prechlorinating when water temperatures exceed 12 °C. This temperature threshold is based on the reproduction characteristics of zebra mussels. However, in recent years, zebra mussels have largely given way to quagga mussels in the region. These mussels reportedly reproduce at temperatures as low as 5 °C. The objective of this study was to determine if the current 12 °C trigger point for prechlorination remains appropriate. A 3-year monitoring program using bioboxes recorded mussel veliger concentrations and settlement potential in water drawn from the intakes of three drinking water treatment plants on Lake Ontario. Water temperature was a poor predictor of veliger presence and settlement. Reproduction and settlement were observed outside of the traditional temperature thresholds. Furthermore, no relationship was found between the number of veligers in the water column and those settling, suggesting that there are complex environmental factors that influence mussel activity. Nevertheless, it was observed that settlement occurred consistently between the months of July and November in the 3 years of the study. Therefore, a calendar-based approach to trigger prechlorination, as opposed to a temperature-based approach, is suggested.
DIDACTICS OF LOGIC IN KEN SCHOOLS AND THE CONCEPTION OF LOGICIN THE "ENCYCLOPÉDIE OU DICTIONNAIRE UNIVERSEL RAISONNÉ"
Authors: Janeczek Stanisław 
Published: March 2021

The paper describes the conception of logic in Polish didactics authored by the Commission of National Education (KEN), an important educational institution of the European Enlightenment. Since the documents of the Commission refer to a vision of science presented by such influential works then as the Encyclopédie ou dictionnaire universel raisonné [Great French Encyclopedia], the paper compares the requirements from the Commission’s programmer with the encyclopaedic entries that entail logical problems broadly understood. It turns out that the Commission, following the Encyclopédie, not only recommended a list of textbooks of logic but also shared its eclectic vision of logic. Although it is characteristic of modernity to take a relative approach to the importance of traditional logic, transformed into science on method, or literally an outline of epistemology, understood according to É. Condillac as a specific form of metaphysics, nevertheless some elements of logic were eclectically made valid. This logic, from the times of I. Kant, has been defined as formal logic. Practical logical skills were preferred to the knowledge of logical theories. At the same time attention was paid to the meaning of natural logical skills, and drills in logical reasoningwhen studying languages and mathematics. Despite preferences for the analytical method they also noticed the importance of synthetic method. It seems also that although the documents of the Commission do not say anything about the teaching of syllogistic issues, in didactic practice inspired by the Encyclopédie in the schools controlled by the Commission, the room was made to teach these problems. Condillac’s book was preferred in the schools controlled by the Commission, nevertheless, it was not, as in the case of other textbooks, a must on the reading list, an obligatory reading matter, therefore it was not published in Poland. The conception of logic presented by the Commission as modelled on the Encyclopédie managed to avoid the one-sidedness of Condillac’s approach, the approach that in fact eliminated the teaching of logic.
GCSF as a Potential Molecular Target for Overall Survival of
Hepatocellular Carcinoma
Authors: Cao Heng , Guo Peng , Wu Xiaohui , Li Jiankun , Ge Chenlong , Wang Shunxiang 
Published: March 2021

Background:
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of digestive tract in the world. Therefore, it is important to carry out studies on the molecular mechanisms of early diagnosis and treatment of HCC to reduce mortality.

Methods:
Bioinformatic analysis was performed to explore the significant role of GCSF on the occurrence and development of neoplasm. Differently expressed genes (DEGs) were screened, and the significant hub genes related with GCSF were identified by the multiple algorithms of Cytoscape. Functional annotation for DEGs, pathological stage and overall survival analysis were implemented. In addition, the verification for the role of GCSF on HCC was made via the clinical samples. A total of 70 participates diagnosed as HCC were recruited from November 2014 to November 2019. The immunohistochemistry assay, qRT-PCR, receiver operating characteristic (ROC) curves, and overall survival analysis were carried out.

Results:
GCSF was related with the tumor size, and the expression of GCSF was up-regulated in hepatocellular carcinoma tissues. The enrichment results of GO and KEGG analysis were mainly enriched in “Inflammatory response”, “Protein binding”, “Metabolic pathways”, and “Proteasome”. The tumor diameter (P < 0.001), and survival time (P < 0.001) were significantly associated with expression of GCSF via the verification of clinical data. The univariate and multivariate Cox proportional regression analysis manifested that high expression of GCSF in patients with HCC was related to poor OS.

Conclusion:
The expression level of GCSF is significantly associated with the prognostic survival of HCC, and it is expected to become a new prognostic marker of HCC, providing a novel idea for future basic research as well as targeted therapy.
Relationship between Augmentation Index and Wall Thickening Fraction during Hypotension in an Animal Model of Myocardial Ischemia-Reperfusion and Heart Failure
Authors: Wray Sandra , Lascano Elena , Negroni Jorge , Fischer Edmundo C. 
Published: March 2021

Aims:
Non-invasive indices to evaluate left ventricular changes during ischemic heart
failure are needed to quantify the myocardial impairment and the effectiveness of therapeutic manoeuvres.
The aims of this work were to calculate the Wall Thickening Fraction (WTF) and the
Augmentation Index (AIx) and to assess the relationship between WTF and AIx using data obtained
from an animal model with heart failure followed by a myocardial ischemia stage and a
reperfusion stage.

Methods:
Nine Corriedale sheep that had been monitored for 10 minutes during a basal stage underwent
5-minute myocardial ischemia, followed by 60-minute reperfusion. Seven of them were subjected
to an induced heart failure through an overdose of halothane, two of which were treated with
intra-aortic counterpulsation during the reperfusion stage. The remaining two animals were monitored
during their ischemia-reperfusion stage.

Results:
Data obtained in the 5 animals suffering from heart failure followed by myocardial ischemia
showed that: a) heart failure induction determined decrease in cardiac output, cardiac index
and systolic and diastolic aortic pressure (AoP) with respect to their basal values (p<0.05), b) myocardial
ischemia decreased the WTF compared with basal and induced heart failure values
(p<0.05), c) during the reperfusion stage accompanied by induced heart failure, WTF increased
with respect to values observed during the ischemia induction stage (p<0.05); nevertheless, basal
values were not recovered after reperfusion (p<0.05). During this 60-minute stage, systolic and diastolic
AoP values were lower (p<0.05) than those at the basal stage.

Conslusion:
AIx and WTF values calculated from synchronically recorded values of aortic pressure
and left ventricular wall thickness during the reperfusion stage in all animals (n = 9) showed a
negative correlation (p<0.05). Analysed data provided evidence of a negative relationship between
a left ventricular index of myocardial function and an arterial index obtained from AoP waves.
Challenges in Breast Cancer Control in Malaysia
Authors: Mokhtar Noor Fatmawati , Dewadas Hemaniswarri Dewi , Haron Juhara , Yahya Maya Mazwin , Norsa’adah Bachok , Zain Wan Zainira Wan , Sulong Sarina , Abdullah Jafri Malin , Zin Reena Rahayu Md 
Published: March 2021

:
High proportion of late presentation and poor survival of women with breast cancer in
Malaysia does not reflect the country’s status as the third richest country in South East Asia.
Herein, we examined, and collated research articles related to breast cancer trajectory i.e., primary,
secondary, and tertiary prevention in Malaysia to understand, appreciate and recognize the achievements
but also gaps which undermine Malaysia’s response in handling the disease. In summary,
the integral task for Malaysia is to strategically align research to improve local data (research) on
the extent of the country’s breast cancer problem, so that effective, comprehensive, and evidence-
based cancer control programs founded on resource level can be generated.
Gold Particles Recovery using Novel Reducing Agent with Regard to Continuous Approach
Authors: Feizbakhsh Alireza , Fotovat Alireza , Garmaroudi Ali Bagheri 
Published: March 2021

Background:Over 300 tonnes of gold utilised in electronics devices every year, end-of-life electronic equipment offers an crucial recycling potential for secondary gold supply. Electronic boards are among common and exploitable sources of gold that are widely used in various industry. The aims of this paper is to use gold element of electronic boards by adjusting its surface functionality and particle size to make this metal to be used in various applicationsMethods:to gain this purpose by using acidic solutions and up to bottom chemical synthesis method among physical, chemical, and biological methods and by transferring gold particle size from micrometer to nanometer, surface-area-to-volume ratio will be increase such that new structural properties emerge, change, or improve.Results:Tests such as Fourier-Transform Infrared spectroscopy, X-Ray Diffraction, and Field Emission Scanning Electron Microscopy have confirmed high-quality production and proper extraction of gold particles on a nanometer scale from electronic plates and confirmed crystalline structure of extracted gold in range of 70-110 nm.Conclusion:The main objective of this research is to derive and fabricate gold nanoparticles using chemical oxidative route using HCl and Aqua regia to produce gold nanoparticles in Nano dimension scale. Results has shown that gold nanoparticles are synthesized successfully via chemical process. Moreover, Acid concentration and reaction time has enormous effect on production procedure.
Rapid Arc-SBRT: Non-Invasive Immune Adjuvant for Advanced Stage Non-Small Cell Lung Carcinoma
Authors: Chairmadurai Arun , Jain Sandeep K. , Jain Aklank , Prakash Hridayesh 
Published: March 2021

Abstract:In conjunction with radio-chemotherapy, pulmonary resection is recommended for early-stage nonsmall- cell lung carcinoma but not for advanced-stage NSCLC patients having high-grade metastatic lesions. In these cases, the rapid Arc-Stereotactic body radiotherapy (Ra-SBRT) technique offers a therapeutic advantage by delivering focal irradiation to metastatic lung lesions and reduces the bystander toxicity to normal tissues. We have previously demonstrated that Ra-SBRT ablates metastatic lesions and induces tumor immune rejection of metastatic tumors by promoting in situ programming of M2 TAM towards M1-TAM and infiltration of Siglec-8+ Eosinophils. Most interestingly, Ra SBRT has very low abscopal impact and spares normal tissues, which are the significant limitations with conventional radiotherapy. In view of this and the immune adjuvant potential of Ra SBRT, it promotes normalization of aberrant vasculature and inhibits the metastatic potential of NSCLC lesions. In view of this, we here propose that Ra-SBRT indeed represents an immunogenic approach for the effective management of advanced-stage NSCLC.
Bridging Indigenous Knowledge and Scientific Evidence for Pharmacological
Studies of Phaleria macrocarpa: A Systematic Review
Authors: Mia Md. Abdur Rashid , Ferdosh Sahena , Ahmed Qamar Uddin , Helaluddin Abul Bashar Mohammed , Sarker Md. Zaidul Islam 
Published: March 2021

Background:
Phaleria macrocarpa (Scheff.) Boerl. (Thymelaeaceae), usually referred
to as God’s crown, Mahkota dewa, Pau, grows all year long in tropical countries, including
Malaysia, Indonesia, Papua New Guinea, and Australia. It is traditionally used to treat haemorrhoids,
stroke, heart disease, tumour, impotence, diabetes, allergies, kidney and liver disorders, migraine,
acne, and skin ailments.

Objective:
The purpose of this systematic review is to provide important insight on P.
macrocarpa’s traditional use, toxicity, classification of compounds, and pharmacological activities,
thus identifying the gap in scientific analysis and potential analytical opportunities for future directions
on this herb.

Method:
The related data for this systematic review were collected from renowned online databases,
namely Wiley Online Library, Web of Science, Springer Link, PubMed, Science Direct, Scopus,
and Google scholar.

Results:
Around 48 compounds, including benzophenone, xanthonoids, norcucurbitacin derivatives,
flavonoids, lignans, fatty acids and esters, phytosterols, aromatic acids, etc., were identified
from different parts. These constituents and different solvent extracts using various identification
techniques have been reported to show a broad range of pharmacological activities. Besides various
traditional claims and pharmacological functions, scientific evidence on its ethnopharmacological
aspects has been well-documented. Studies found that the plant demonstrates anti-diabetic, anti-
oxidant, antimicrobial, anticancer, anti-hypercholesterolemia, and antihypertensive activities.

Conclusion:
Despite various claims, there is still inadequate scientific evidence, particularly on P.
macrocarpa’s benefit in the management of dysentery, asthma, skin diseases, and rheumatoid
arthritis, necessitating future studies. There is also a need to test its pharmacokinetics and toxicological
data on humans to verify its potential bioactive properties.
An Automatic Instrument Recognition Approach Based on Deep Convolutional Neural Network
Authors: Ke Jiangyan , Lin Rongchuan , Sharma Ashutosh 
Published: March 2021

Background:
This paper presents an automatic instrument recognition method highlighting
the deep learning aspect of instrument identification in order to advance the automatic process
of video monitoring remotely equipment of substation.

Methods:
This work utilizes the Scale Invariant Feature Transform approach (SIFT) and the
Gaussian difference model for instrument positioning while proposing a design scheme of the instrument
identification system.

Results:
The experimental outcomes obtained proves that the proposed system is capable of automatically
recognizing a modest graphical interface and study independently while improving the
effectiveness of the appliance, thereby, realizing the purpose of spontaneous self-check. The proposed
approach is applicable for musical instrument recognition, and it provides 92% of the accuracy
rate, 87.5% precision value and recall rate of 91.2%.

Conclusion:
The comparative analysis with other state-of-the-art methods justifies that the proposed
deep learning-based music recognition method outperforms the other existing approaches in
terms of accuracy, thereby providing a practicable music instrument recognition solution.
Discovery of Potential Inhibitors of the Receptor-binding Domain (RBD)
of Pandemic Disease-causing SARS-CoV-2 Spike Glycoprotein from
Triphala Through Molecular Docking
Authors: Khan Sharuk L. , Siddiqui Falak A. , Shaikh Mohd Sayeed , Nema Nitin V. , Shaikh Aijaz A. 
Published: March 2021

Background:
COVID-19 (SARS-CoV-2 infection) has affected almost every region of
the world. Presently, there is no defined line of treatment available for it. Triphala is already
proven to have a safe biological window, which is well known for its antioxidant and
immunomodulatory properties.

Objective:
The present work has been carried out to study Triphala's effectiveness in the treatment
of COVID-19.

Methods:
The Receptor-binding domain (RBD) of SARS-CoV-2 Spike Glycoprotein is responsible
for the invasion into the host cell, which leads to further infection. The molecular docking (MD)
was performed to explore the binding affinities (kcal/mol) of Triphala's chemical constituents and
compared them with the existing drugs under investigation for the treatment of COVID-19
epidemiology.

Results:
Chebulinic acid binding affinity -8.5 kcal/mol with the formation of 10 hydrogen bonds.
Almost all the major chemical constituents have formed two or more hydrogen bonds with RBD of
SARS-CoV-2 Spike Glycoprotein.

Conclusion:
The present study showed that Triphala might perform vital roles in the treatment of
COVID-19 and expand its usefulness to physicians to treat this illness. There is a need to complete
the in-vitro, in-vivo biological testing of Triphala on SARS-CoV-2 disease to create more quality
data. The binding mode of Chebulinic acid in the allosteric cavity allows a better understanding of
RBD of SARS-CoV-2 Spike Glycoprotein target and provides insight for the design of new
inhibitors. Triphala is already proven to have a safe biological window, which indicates that we
can skip the pre-clinical trials. Apart from this, Triphala is well known for its antioxidant
properties, which ultimately improve the immunity of the COVID-19 patient.