bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of serum levels of titanium and aluminium ions in patients with early onset scoliosis operated upon using the magnetic growing rod—a single centre study of 14 patients
Authors: Borde Mandar Deepak , Sapare Sarang , Schutgens Emile , Ali Chadi , Noordeen Hilali 
Published: July 2021

Abstract
Study design
A cross-sectional retrospective Level 3 study.

Objective
To study the serum levels of Titanium and Aluminium ions in patients operated using the magnetically controlled growing rod (MCGR) system.

Summary of background data
14 consecutive patients of early onset scoliosis with varying etiology managed with MCGR system with a minimum follow-up of 24 months were selected for the study. The group consisted of two boys (14.3%) and 12 girls (85.7%). The average age of the patients at the time of surgery was 10.4 years (5–15 years). The average period of follow-up was 43.7 months (28–79 months). After informed consent of the subjects and their caretakers, serum levels of titanium and aluminium were measured. These levels were then assessed with regards to the number of screws used, number of distractions and complications.

Methods
The concentration of titanium and aluminium ions in the serum was measured using high resolution inductively coupled plasma mass spectrometry.

Results
For the sake of ease of assessment, patients were divided into three etiology-based groups—idiopathic (n = 6), neuromuscular (n = 2) and syndromic (n = 6). The mean serum titanium level was 15.9 μg/L (5.1–28.2 μg/L) while that of aluminium was 0.1 μmol/L (0.1–0.2 μmol/L). Of the 14 patients, 2 (14.2%) patients had mechanical failure (actuator pin dysfunction), 3 (21.4%) had rod breakage requiring revision surgery and one patient (7.1%) had surgical site infection managed with appropriate antibiotics. Patients undergoing revision for rod breakage did not show any metallosis of the tissues during surgery.

Conclusion
Analysis of patients with scoliosis operated using the magnetic growing rod system concludes that it is accompanied by presence of titanium in the blood but whether clinically significant or not needs to be ascertained by comparison of preoperative and postoperative blood concentrations of the titanium ions in individual subjects. The aluminium ion concentration remains within normal limits. Though implant malfunction may raise the titanium levels in the blood, its clinical significance needs to be determined. The aluminium levels are not affected irrespective to the presence or absence of complications. The long-term effects of raised titanium levels in the blood also warrant further prospective studies designed for precise and deeper analyses.
Other knowings and experiencing otherness: Children’s perspectives of playing a hunting game in a nature reserve
Authors: Adams Dylan , Beauchamp Gary 
Published: July 2021

AbstractThis research study explored the experiences of children (aged 9–10 years), from four different primary schools, playing a hunting game in a nature reserve. Previous research shows that children’s play in green spaces can provide a number of benefits to children. However, there is a lack of research into children’s experiences of playing in bio-diverse environments. This study sought to find out how children (aged 9–10 years) “playing” the role of animals in a nature reserve could enable them to experience different ways of being and different ways of understanding their relationship with the world around them. The study employed a qualitative phenomenological design that aimed to interpret the first-person lived experiences of the children playing in the nature reserve. Four classes from four different primary schools took part in the study. Six children from each class were interviewed and analysis of their responses generated a number of different themes. The results suggest that playing the hunting game in a biodiverse environment does offer states of being and knowings that are not as accessible in schools. Playing the role of an animal had afforded the children with an accentuated, embodied experience, offering insight into the otherness of the more-than-human world.
Risks of Occupational-Related Adverse Events (ORAEs) and Effect of Bundled Interventions Among Health Care Workers in Novel Coronavirus Pneumonia Wards
Authors: Luo Tinggang , Guo Yao , Shi Ying , Song Yujian , Xu Wenchao , You Jianping 
Published: July 2021

Abstract

Objective:
The aims of the study were to investigate the burden for health care workers (HCWs) who suffer from occupational-related adverse events (ORAEs) while working in contaminated areas in a specialized hospital for novel coronavirus pneumonia, to explore related risk factors, to evaluate the effectiveness of bundled interventions, as well as to provide scientific evidence regarding the reduction of risks concerning ORAEs and occupational exposure events.

Methods:
The study was completed using a special team of 138 HCWs assembled for a specialized hospital for novel coronavirus pneumonia in Wuhan, dated from February 16 to March 26, 2020. The incidence of occupational exposure was determined by data reported from the hospital, while the prevalence of ORAEs was derived from questionnaire results. The relation coefficients of ORAEs and the variable potential risk factors are analyzed by logistic regression. After the risk factors were identified, targeted organized intervention was implemented and chi-square tests were performed to compare the incidence of occupational exposure and the prevalence of ORAEs in contaminated areas before and after the interventions.

Results:
Ninety one out of 138 (65.94%) had reported ORAEs with 300 (27.96%) cases of ORAEs being recorded in a total of 1073 entries into contaminated areas. The prevalence of different ORAEs include 205 tenderness (24.73%), 182 headache/dizziness (21.95%), 138 dyspnea (16.65%), 130 blurred vision (15.68%), and 95 nausea/vomiting (11.46%). Personal protective equipment (PPE) is significantly associated with ORAEs in contaminated areas (P < 0.05). Among non-PPE-related factors, insomnia is associated with the majority of ORAEs in contaminated areas. Significant differences were achieved after organized interventions in the incidence of occupational exposure of HCWs (χ2 = 39.07, P < 0.001) and the prevalence of ORAEs in contaminated areas (χ2 = 22.95, P < 0.001).

Conclusion:
During the epidemic period of novel severe respiratory infectious disease, the burden of the ORAEs in contaminated areas and the risk of occupational exposure of HCWs were relatively high. In time, comprehensive and multi-level bundled interventions may help decrease the risk of both ORAEs and occupational exposure.
The Pandemic Is Not Occurring in a Vacuum: The Impact of COVID-19 and Other Disasters on Workforce Mental Health in Australia
Authors: Podubinski Tegan , Glenister Kristen M. 
Published: July 2021

AbstractObjective:Prior to coronavirus disease (COVID-19), many Australians experienced extreme bushfires, droughts, and floods. A history of experiencing these events might be a risk factor for increased psychological distress during COVID-19. This study aimed to provide insight into the mental health of Australian workers during the initial COVID-19 outbreak, with an additional focus on whether previous disaster exposure and impact from that disaster is a risk factor for increased psychological distress.Methods:A snowball recruitment strategy was used. Participants (n = 596) completed an online survey, which included the Depression Anxiety Stress Scales-21, and questions related to mental health and disaster exposure.Results:Overall, 19.2%, 13.4%, and 16.8% of participants were experiencing moderate to extremely severe depression, anxiety, and stress symptoms, respectively. Multiple regression found that higher depression, anxiety, and stress symptoms were associated with a pre-existing mental health diagnosis; only higher stress symptoms were associated with having experienced a disaster, with impact, in addition to COVID-19.Conclusions:People who have experienced impact from an additional disaster might need additional support to protect their mental health during COVID-19. A focus on the cumulative mental health impacts of multiple disasters and the implications for organizational communities where recovery work is undertaken, such as schools and workplaces, is needed.
Microbial bioburden of inpatient and outpatient areas beyond patient hospital rooms
Authors: Cadnum Jennifer L. , Pearlmutter Basya S. , Jencson Annette L. , Haydar Hanan , Hecker Michelle T. , Ray Amy J. , Tomas Myreen E. , Saade Elie A. , Donskey Curtis J. 
Published: July 2021

AbstractObjective:To investigate the frequency of environmental contamination in hospital areas outside patient rooms and in outpatient healthcare facilities.Design:Culture survey.Setting:This study was conducted across 4 hospitals, 4 outpatient clinics, and 1 surgery center.Methods:We conducted 3 point-prevalence culture surveys for methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, Clostridioides difficile, Candida spp, and gram-negative bacilli including Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter baumanii, and Stenotrophomonas maltophilia in each facility. In hospitals, high-touch surfaces were sampled from radiology, physical therapy, and mobile equipment and in emergency departments, waiting rooms, clinics, and endoscopy facilities. In outpatient facilities, surfaces were sampled in exam rooms including patient and provider areas, patient bathrooms, and waiting rooms and from portable equipment. Fluorescent markers were placed on high-touch surfaces and removal was assessed 1 day later.Results:In the hospitals, 110 (9.4%) of 1,195 sites were positive for 1 or more bacterial pathogens (range, 5.3%–13.7% for the 4 hospitals) and 70 (5.9%) were positive for Candida spp (range, 3.7%–5.9%). In outpatient facilities, 31 of 485 (6.4%) sites were positive for 1 or more bacterial pathogens (range, 2% to 14.4% for the 5 outpatient facilities) and 50 (10.3%) were positive for Candida spp (range, 3.9%–23.3%). Fluorescent markers had been removed from 33% of sites in hospitals (range, 28.4%–39.7%) and 46.3% of sites in outpatient clinics (range, 7.4%–82.8%).Conclusions:Surfaces in hospitals outside patient rooms and in outpatient facilities are frequently contaminated with healthcare-associated pathogens. Improvements in cleaning and disinfection practices are needed to reduce contamination.
TOPOLOGICAL 4-MANIFOLDS WITH 4-DIMENSIONAL FUNDAMENTAL GROUP
Authors: KASPROWSKI DANIEL , LAND MARKUS 
Published: July 2021

AbstractLet$\pi$be a group satisfying the Farrell–Jones conjecture and assume that$B\pi$is a 4-dimensional Poincaré duality space. We consider topological, closed, connected manifolds with fundamental group$\pi$whose canonical map to$B\pi$has degree 1, and show that two such manifolds ares-cobordant if and only if their equivariant intersection forms are isometric and they have the same Kirby–Siebenmann invariant. If$\pi$is good in the sense of Freedman, it follows that two such manifolds are homeomorphic if and only if they are homotopy equivalent and have the same Kirby–Siebenmann invariant. This shows rigidity in many cases that lie between aspherical 4-manifolds, where rigidity is expected by Borel’s conjecture, and simply connected manifolds where rigidity is a consequence of Freedman’s classification results.
Minimally invasive permanent pacemaker implantation immediately after birth: from delivery room to heart surgery
Authors: Taşar Mehmet , Yaman Nur Dikmen , Arıcı Burcu , Aksoy Ömer Nuri , Dursin Huseyin , Ayaz Aslı , Citli Rümeysa , Özgür Senem , Sayıcı İlker Ufuk 
Published: July 2021

AbstractIntroduction:Congenital atrioventricular block is diagnosed in uterine life, at birth, or early in life. Atrioventricular blocks can be life threatening immediately at birth so urgent pacemaker implantation techniques are requested. Reasons can be cardiac or non-cardiac, but regardless of the reason, operations are challenging. We aimed to present technical procedure and operative results of pacemaker implantation in neonates.Materials and methods:Between June 2014 and February 2021, 10 neonates who had congenital atrioventricular block underwent surgical operation to implant permanent epicardial pacemaker by using minimally invasive technique. Six of the patients were female and four of them were male. Mean age was 4.3 days (0–11), while three of them were operated on the day of birth. Mean weight was 2533 g (1200–3300).Results:Operations were achieved through subxiphoidal minimally skin incision. Epicardial 25 mm length dual leads were implanted on right ventricular surface and generators were fixed on the right (seven patients) or left (three patients) diaphragmatic surface by incising pleura. There were no complication, morbidity, and mortality related to surgery.Conclusion:Few studies have characterised the surgical outcomes following epicardial permanent pacemaker implantation in neonates. The surgical approach is attractive and compelling among professionals so we aimed to present the techniques and results in patients who required permanent pacemaker implantation in the first month of life.
Wealth wars: how productivity gaps explain democratic erosion in advanced economies
Authors: Timoneda Joan C. 
Published: July 2021

AbstractWhy are democracies backsliding? I contend that a large productivity gap between economic groups motivates those with low productivity to capture the state for rent-seeking. They assess their relative position as weak and are willing to sacrifice certain democratic guarantees in exchange for favorable policies. Erosion takes two forms. (1) With high inter-class inequality and a large productivity gap among economic industries, losing economic elites capture the state through a political outsider who enacts favorable policy. Once in office, the outsider expands his personal executive control and attacks key democratic veto players. (2) When inter-class inequality is high but the inter-industry productivity gap is small, a united economic elite coordinate to stop a populist takeover. Traditional political elites respond to the populist threat by curtailing basic freedoms of speech and association. I use both quantitative and case study evidence from the US and Spain to support my main hypotheses.
Vertical Mixing in Stratified Fjords Near Tidewater Outlet Glaciers Along Northwest Greenland
Authors: Bendtsen Jørgen , Rysgaard Søren , Carlson Daniel F. , Meire Lorenz , Sejr Mikael K. 
Published: July 2021

AbstractVertical mixing of upper water masses in Arctic fjords is important for circulation and transport of nutrients and heat. However, the distribution of turbulent mixing is poorly known. Here we present hydrographic and microscale turbulence measurements from six fjords in Northwestern (69°N–75°N) Greenland. Water mass distributions showed the presence of warm bottom water of Atlantic origin in all fjord transects and a significant modification of upper water masses in fjords with tidewater outlet glaciers. Spatial and temporal distribution of turbulence in the fjords showed, in general, low rates of turbulent kinetic energy, ε (∼10−9 W kg−1), and strong stratification implies that vertical exchange in the upper ∼200 m was relatively weak. However, measurements within 2 km of the terminus of a tidewater outlet glacier showed values of ε and inferred turbulent diffusion coefficients >10−4 m2 s−1 that were about two orders of magnitude larger than elsewhere in the deep fjords. This elevated mixing corresponded to comparatively large heat and salt fluxes. These observations suggest that vertical mixing near tidewater outlet glaciers results in localized mixing hot spots, likely due to subglacial discharge and near‐glacial current shear, that contribute significantly to vertical exchange in the deep fjords.
The Impact of Perturbing Eddy Diffusion and Upper Boundary on the Ionosphere EnKF Assimilation System
Authors: He Jianhui , Yue Xinan 
Published: July 2021

AbstractAccurate representation of ensemble members of coupled Ionosphere‐Thermosphere (I‐T) is crucial to the ionosphere forecast in the ensemble Kalman filter (EnKF) data assimilation system. In this paper, besides the model drivers used in previous studies, including the solar 10.7 cm radio flux (F10.7), auroral hemispheric power (HP) and cross‐tail potential drop (CP), the eddy diffusion coefficient (ED), and nighttime vertical O+ flux at the top boundary are also perturbed to generate ensemble members. Based on our developed EnKF data assimilation system, the impact of perturbing different model external forcing parameters on ensemble generation and forecast capability of ionosphere and thermosphere has been investigated in detail through a series of sensitivity tests and data assimilation experiments. This system uses the National Center for Atmospheric Research (NCAR) Thermosphere Ionosphere Electrodynamics General Circulation Model (TIEGCM) as a background model. The findings are summarized as follows: (a) Associated with perturbing two additional model forcing parameters, better ensemble members of ionosphere and thermosphere states of the background model can be generated during both daytime and nighttime. (b) The improvement of the forecast capability of the ionosphere and thermosphere variables can be further enhanced. This study can provide a reference for ensemble generating strategy for the coupled I‐T EnKF data assimilation in the future.
Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae
Authors: Damen Michelle S. M. A. , Stankiewicz Traci E. , Park Se-Hyung , Helsley Robert N. , Chan Calvin C. , Moreno-Fernandez Maria E. , Doll Jessica R. , Szabo Sara , Herbert De’Broski R. , Softic Samir , Divanovic Senad 
Published: July 2021

AbstractObjectiveThe risks of excess sugar intake in addition to high-fat diet consumption on immunopathogenesis of obesity-associated metabolic diseases are poorly defined. Interleukin-4 (IL-4) and IL-13 signaling via IL-4Rα regulates adipose tissue lipolysis, insulin sensitivity, and liver fibrosis in obesity. However, the contribution of IL-4Rα to sugar rich diet-driven obesity and metabolic sequelae remains unknown.MethodsWT, IL-4Rα-deficient (IL-4Rα−/−) and STAT6-deficient mice (STAT6−/−) male mice were fed low-fat chow, high fat (HF) or HF plus high carbohydrate (HC/fructose) diet (HF + HC). Analysis included quantification of: (i) body weight, adiposity, energy expenditure, fructose metabolism, fatty acid oxidation/synthesis, glucose dysmetabolism and hepatocellular damage; (ii) the contribution of the hematopoietic or non-hematopoietic IL-4Rα expression; and (iii) the relevance of IL-4Rα downstream canonical STAT6 signaling pathway in this setting.ResultsWe show that IL-4Rα regulated HF + HC diet-driven weight gain, whole body adiposity, adipose tissue inflammatory gene expression, energy expenditure, locomotor activity, glucose metabolism, hepatic steatosis, hepatic inflammatory gene expression and hepatocellular damage. These effects were potentially, and in part, dependent on non-hematopoietic IL-4Rα expression but were independent of direct STAT6 activation. Mechanistically, hepatic ketohexokinase-A and C expression was dependent on IL-4Rα, as it was reduced in IL-4Rα-deficient mice. KHK activity was also affected by HF + HC dietary challenge. Further, reduced expression/activity of KHK in IL-4Rα mice had a significant effect on fatty acid oxidation and fatty acid synthesis pathways.ConclusionOur findings highlight potential contribution of non-hematopoietic IL-4Rα activation of a non-canonical signaling pathway that regulates the HF + HC diet-driven induction of obesity and severity of obesity-associated sequelae.
AHR-dependent genes and response to MTX therapy in rheumatoid arthritis patients
Authors: Wajda Anna , Walczuk Ewa , Stypińska Barbara , Lach Jakub , Yermakovich Danat , Sivitskaya Larysa , Romanowska-Próchnicka Katarzyna , Wysocki Tomasz , Jarończyk Małgorzata , Paradowska-Gorycka Agnieszka 
Published: July 2021

AbstractMethotrexate (MTX) is the first-line therapy for rheumatoid arthritis. Nevertheless, MTX resistance is quite a common issue in clinical practice. There are some premises that aryl hydrocarbon receptor (AhR) gene battery may take part in MTX metabolism. In the present retrospective study, we analyzed genes expression of AHR genes battery associated with MTX metabolism in whole blood of RA patients with good and poor response to MTX treatment. Additionally, sequencing, genotyping and bioinformatics analysis of AHR repressor gene (AHRR) c.565C > G (rs2292596) and c.1933G > C (rs34453673) have been performed. Theoretically, both changes may have an impact on H3K36me3 and H3K27me3. Evolutionary analysis revealed that rs2292596 may be possibly damaging. Allele G in rs2292596 and DAS28 seems to be associated with a higher risk of poor response to MTX treatment in RA. RA patients with poor response to MTX treatment revealed upregulated AhR and SLC19A1 mRNA level. Treatment with IL-6 inhibitor may be helpful to overcome the low-dose MTX resistance. Analysis of gene expression revealed possible another cause of poor response to MTX treatment which is different from that observed in the case of acute lymphoblastic leukemia.
G6PD distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19
Authors: da Rocha Jorge E. B. , Othman Houcemeddine , Tiemessen Caroline T. , Botha Gerrit , Ramsay Michèle , Masimirembwa Collen , Adebamowo Clement , Choudhury Ananyo , Brandenburg Jean-Tristan , Matshaba Mogomotsi , Simo Gustave , Gamo Francisco-Javier , Hazelhurst Scott ,   as members of the H3Africa Consortium, da Rocha Jorge E. B. 
Published: July 2021

AbstractChloroquine/hydroxychloroquine have been proposed as potential treatments for COVID-19. These drugs have warning labels for use in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Analysis of whole genome sequence data of 458 individuals from sub-Saharan Africa showed significant G6PD variation across the continent. We identified nine variants, of which four are potentially deleterious to G6PD function, and one (rs1050828) that is known to cause G6PD deficiency. We supplemented data for the rs1050828 variant with genotype array data from over 11,000 Africans. Although this variant is common in Africans overall, large allele frequency differences exist between sub-populations. African sub-populations in the same country can show significant differences in allele frequency (e.g. 16.0% in Tsonga vs 0.8% in Xhosa, both in South Africa, p = 2.4 × 10−3). The high prevalence of variants in the G6PD gene found in this analysis suggests that it may be a significant interaction factor in clinical trials of chloroquine and hydroxychloroquine for treatment of COVID-19 in Africans.