bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation Analysis of Flow Rate Variability During Microinfusions: The Effect of Vertical Displacement and Multidrug Infusion in Conventional Infusion Pumps Versus New Cylinder-Type Infusion Pumps
Authors: Oh Eun Jung , Hong Kwan Young , Lee Jong-Hwan , Kim Duk Kyung , Cho Joongbum , Min Jeong-Jin 
Published: December 2021

BACKGROUND:
Medication dosing errors can occur during microinfusions when there is vertical pump displacement or multidrug infusion through a single intravenous path. We compared flow rate variability between new-generation cylinder-type infusion pumps and conventional infusion pumps under simulated conditions.

METHODS:
We evaluated the flow rates during microinfusions using different infusion pumps (syringe pump with 10/30/50-mL syringes, peristaltic pump, and cylinder pump). Two visible dyes were used as model drugs. The study samples were quantified using spectrophotometry. For vertical displacement, the infusion pumps were moved up and down by 60 cm during microinfusions at 0.5 mL·h−1 and 2 mL·h−1. In the multi-infusion study, the second drug flow was added through 4 linearly connected stopcocks either upstream or downstream of the first drug. We compared the total error dose between the cylinder pump and the syringe pump with a Mann-Whitney U test and additionally estimated the effects of the infusion pumps on total error doses by linear regression analysis.

RESULTS:
There were repetitive patterns of temporary flow increases when the pump was displaced upward and flow decreases when the pump was displaced downward in all settings. However, the amount of flow irregularities was more pronounced at the lower infusion rate and in the syringe-type pump using larger volume syringes. The total error dose increased in the syringe pump loaded with a 50-mL syringe compared to that of the new cylinder pump (regression coefficient [β] = 4.66 [95% confidence interval {CI}, 1.60–7.72]; P = .008). The initiation and cessation of a new drug during multidrug microinfusion in the same intravenous path affected the lower rate first drug leading to a transient flow rate increase and decrease, respectively. The change in flow rate was observed regardless of the port selected for addition of the second drug, and the total error dose of the first drug did not significantly vary when an upstream or a downstream port was selected.

CONCLUSIONS:
In the microinfusion settings, attention must be paid to the use of the syringe pump loaded with large-volume syringes. The novel cylinder pump could be considered as a practical alternative to syringe pumps with small syringes given its flow stability without the need for frequent drug replacement.
Frequency of parasitic infections in Arachishypogaea L (groundnuts), Citrulluslanatus seeds (watermelon seeds), and Ziziphusspina-christi (nabag) sold by street vendors in Khartoum State, Sudan: a cross-sectional study
Authors: Suleiman Mohammed Arwa , Abd Alla Ahmed , Galander Ahmed , Elfaki Tayseer , Ibrahim Hashim Ahmed , N. Altayb Hisham 
Published: December 2021

Background: Plant products, including seeds are an important source of vitamins, minerals, proteins, and energy. This study aimed to assess parasitic contaminations in roasted groundnuts, nabag, and tasali (watermelon seeds) sold by street vendors in Khartoum State, Sudan. Methods: The frequency of parasitic contaminations among all crop products was detected by washing the plants with saline, and then conducting an examination using a formal ether concentration technique (FECT), followed by a saturated sugar floatation technique. Results: The detected parasites belonged to two species: Entamoeba histolytica (33.3%) and Giardia lamblia (15.6%). No helminthic parasites were detected. Mixed contamination of the mentioned parasites was also observed (11.1%). The most contaminated crop was nabag, followed by groundnut, and finally tasali. Conclusion: No relation was established between the positivity of samples for parasites and crop type, Khartoum State city, or seller sex. FECT was more sensitive than the saturated sugar floatation technique as a detection method.
Postfundamentals Price Drift in Capital Markets: A Regression Regularization Perspective
Authors: Avramov Doron , Kaplanski Guy , Subrahmanyam Avanidhar 
Published: December 2021

Regression regularization techniques show that deviations of accounting fundamentals from their preceding moving averages forecast drifts in equity market prices. Deviations-based predictability survives a comprehensive set of prominent anomalies. The profitability applies strongly to the long leg and survives value weighting and excluding microcaps. We provide evidence that the predictability arises because investors anchor to recent means of fundamentals. A factor based on our fundamentals-based index yields economically significant intercepts after controlling for a comprehensive set of other factors, including those based on profit margins and earnings drift.This paper was accepted by Gustavo Manso, finance.
Spatio-Temporal Pricing for Ridesharing Platforms
Authors: Ma Hongyao , Fang Fei , Parkes David C. 
Published: December 2021

Ridesharing platforms have radically changed the way people get around in urban areas, but there remain challenges undercutting the mission of “making transportation as reliable as running water.” A particular concern is that drivers strategize: calling riders to find out their destinations and canceling trips that are not worthwhile, declining trips and chasing surge prices in neighboring areas, and going off-line before large events will end in anticipation of a price increase. In this work, we show that such strategic behaviors are symptoms of inefficiencies in the pricing and dispatching rules governing today's platforms. We propose the Spatio-Temporal Pricing mechanism, which solves for the welfare-optimal matching of drivers to trips, and sets prices that are appropriately smooth in both space and time such that the best thing for drivers to do is accept any proposed trip dispatch. This demonstrates that ridesharing platforms can succeed in optimally orchestrating trips and providing reliable transpiration for riders, while still leaving drivers with the flexibility to decide how to work.
The outcome of the uncemented acetabular component in delayed total hip arthroplasty following acetabular fractures
Authors: El-Bakoury Ahmed , Khedr Waseem , Williams Mark , Eid Yousry , Hammad Abdullah Said 
Published: December 2021

Aims After failed acetabular fractures, total hip arthroplasty (THA) is a challenging procedure and considered the gold standard treatment. The complexity of the procedure depends on the fracture pattern and the initial fracture management. This study’s primary aim was to evaluate patient-reported outcome measures (PROMs) for patients who underwent delayed uncemented acetabular THA after acetabular fractures. The secondary aims were to assess the radiological outcome and the incidence of the associated complications in those patients. Methods A total of 40 patients underwent cementless acetabular THA following failed treatment of acetabular fractures. The postoperative clinical and radiological outcomes were evaluated for all the cohort. Results The median (interquartile range (IQR)) Oxford Hip Score (OHS) improved significantly from 9.5 (7 to 11.5), (95% confidence interval (CI) (8 to 10.6)) to 40 (39 to 44), (95% CI (40 to 43)) postoperatively at the latest follow-up (p < 0.001). It was worth noting that the initial acetabular fracture type (simple vs complex), previous acetabular treatment (ORIF vs conservative), fracture union, and restoration of anatomical centre of rotation (COR) did not affect the final OHS. The reconstructed centre of rotation (COR) was restored in 29 (72.5%) patients. The mean abduction angle in whom acetabular fractures were managed conservatively was statistically significantly higher than the surgically treated patients 42.6° (SD 7.4) vs 38° (SD 5.6)) (p = 0.032). We did not have any case of acetabular or femoral loosening at the time of the last follow-up. We had two patients with successful two-stage revision for infection with overall eight-year survival rate was 95.2% (95% CI 86.6% to 100%) with revision for any reason at a median (IQR) duration of follow-up 50 months (16 to 87) months following THA. Conclusion Delayed cementless acetabular THA in patients with previous failed acetabular fracture treatments produces good clinical outcomes (PROMS) with excellent survivorship, despite the technically demanding nature of the procedure. The initial fracture treatment does not influence the outcome of delayed THA. In selected cases of acetabular fractures (either nondisplaced or with secondary congruency), the initial nonoperative treatment neither resulted in large acetabular defects nor required additional acetabular reconstruction at the time of THA. Cite this article: Bone Jt Open 2021;2(12):1067–1074.
Assessing the reliability of automatic sentiment analysis tools on rating the sentiment of reviews of NHS dental practices in England
Authors: Byrne Matthew , O’Malley Lucy , Glenny Anne-Marie , Pretty Iain , Tickle Martin 
Published: December 2021

BackgroundOnline reviews may act as a rich source of data to assess the quality of dental practices. Assessing the content and sentiment of reviews on a large scale is time consuming and expensive. Automation of the process of assigning sentiment to big data samples of reviews may allow for reviews to be used as Patient Reported Experience Measures for primary care dentistry.AimTo assess the reliability of three different online sentiment analysis tools (Amazon Comprehend DetectSentiment API (ACDAPI), Google and Monkeylearn) at assessing the sentiment of reviews of dental practices working on National Health Service contracts in the United Kingdom.MethodsA Python 3 script was used to mine 15800 reviews from 4803 unique dental practices on theNHS.ukwebsites between April 2018 –March 2019. A random sample of 270 reviews were rated by the three sentiment analysis tools. These reviews were rated by 3 blinded independent human reviewers and a pooled sentiment score was assigned. Kappa statistics and polychoric evalutaiton were used to assess the level of agreement. Disagreements between the automated and human reviewers were qualitatively assessed.ResultsThere was good agreement between the sentiment assigned to reviews by the human reviews and ACDAPI (k = 0.660). The Google (k = 0.706) and Monkeylearn (k = 0.728) showed slightly better agreement at the expense of usability on a massive dataset. There were 33 disagreements in rating between ACDAPI and human reviewers, of which n = 16 were due to syntax errors, n = 10 were due to misappropriation of the strength of conflicting emotions and n = 7 were due to a lack of overtly emotive language in the text.ConclusionsThere is good agreement between the sentiment of an online review assigned by a group of humans and by cloud-based sentiment analysis. This may allow the use of automated sentiment analysis for quality assessment of dental service provision in the NHS.
“Debemos encontrar un nuevo relato para encarnar una historia escolar renovada…” Entrevista a Gonzalo de Amézola
Authors: Lasave Lara , Coudannes Mariela 
Published: December 2021

El profesor Gonzalo de Amézola no necesita presentación para los lectores habituales de nuestra revista. Tenemos el gusto de conversar una vez más con uno de los fundadores de Clío & Asociados. La historia enseñada, e integrante fundamental de su equipo de dirección hasta el año 2020. Por otra parte es ampliamente conocido su extenso aporte a la formación docente en historia y a la investigación en el campo de la didáctica específica en el país. Le rendimos de esta manera un merecido reconocimiento a su recorrido y recuperamos sus imprescindibles puntos de vista críticos sobre el presente y el futuro de la enseñanza de la historia.
Commercial immunoassays for detection of anti-SARS-CoV-2 spike and RBD antibodies: urgent call for validation against new and highly mutated variants
Authors: Lippi Giuseppe , Adeli Khosrow , Plebani Mario 
Published: December 2021

Abstract
Measuring the level of protection conferred by anti-SARS-CoV-2 (trimeric) spike or RBD (receptor binding domain) antibodies (especially total and IgG) is a suitable and reliable approach for predicting biological protection against the risk of infection and severe coronavirus disease 2019 (COVID-19) illness. Nonetheless, SARS-CoV-2 has undergone a broad process of recombination since the identification of the prototype lineage in 2019, introducing a huge number of mutations in its genome and generating a vast array of variants of interest (VoI) and concern (VoC). Many of such variants developed several mutations in spike protein and RBD, with the new Omicron (B.1.1.529) clade displaying over 30 changes, 15 of which concentrated in the RBD. Besides their impact on virus biology, as well as on the risk of detection failure with some molecular techniques (i.e., S gene dropout), recent evidence suggests that these mutations may also jeopardize the reliability of currently available commercial immunoassays for detecting anti-SARS-CoV-2 antibodies. The antigen (either spike or RBD) and epitopes of the prototype SARS-CoV-2 coated in some immunoassays may no longer reflect the sequence of circulating variants. On the other hand, anti-SARS-CoV-2 antibodies elicited by highly mutated SARS-CoV-2 variants may no longer be efficiently recognized by the currently available commercial immunoassays. Therefore, beside the compelling need to regularly re-evaluate and revalidate all commercially available immunoassays against live virus neutralization assays based on emerging VoCs or VoIs, diagnostic companies may also consider to redevelop their methods, replacing former SARS-CoV-2 antigens and epitopes with those of the new variants.
Effect of bacterial cellulose nanofibers incorporation on acid-induced casein gels: microstructures and rheological properties
Authors: Yuan Kai , Li Xiaofei , Yang Xudong , Luo Shuai , Yang Xi , Guo Yurong 
Published: December 2021

Abstract
In this study, the effect of bacterial cellulose nanofibers (BCNF) incorporation on the structural and rheological properties of casein gels was investigated, where the mixed BCNF and casein gels were prepared by adding gluconic acid δ-lactone (GDL) to acidify the mixed polymer solutions at 3.0% casein concentration (w/v) and varying BCNF concentrations (0–0.5%, w/v). By changing the addition amount of GDL, the mechanical and structural properties of the mixed gels were studied at above, near and below the electric point (pI) of the casein. At pH above the pI of the casein, the introduction of BCNF initially increased the gel strength, but further addition of BCNF weakened the mixed gels. At near and below the pI of the casein, the incorporation of BCNF continuously increased the gel strength. Besides, all gels showed good structural homogeneity, without macroscopic phase separation occurring, which indicated good compatibility of BCNF with the casein gels.
Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis
Authors: Rahnemaei Fatemeh Alsadat , Pakzad Reza , Amirian Azam , Pakzad Iraj , Abdi Fatemeh 
Published: December 2021

Abstract
Gestational diabetes mellitus (GDM) can have adverse effects on pregnancy. GDM is associated with changes in the lipid profile of pregnant women. Finding out the early ways to diagnose GDM can prevent the adverse outcomes. This meta-analysis study aimed to determine the effect of GDM on lipid profile. PubMed, ProQuest, Web of Science, Scopus, Science Direct, Google Scholar, and ClinicalTrial were systematically searched for published articles relating to GDM until 2021 according to PRISMA guidelines. Newcastle Ottawa scale was used to assess the quality of the studies. Thirty-three studies with a sample size of 23,792 met the criteria for entering the meta-analysis. Pooled standardized mean difference (SMD) for total cholesterol (TC) and triglyceride (TG) was 0.23 mg/dL (95% CI: 0.11–0.34) and 1.14 mg/dL (95% CI: 0.91–1.38), respectively. The mean of TC and TG in people with GDM was higher than that in normal pregnant women. A similar pattern was observed for the very low-density lipoprotein (VLDL) and TG/high-density lipoprotein (HDL) ratio, with pooled SMD of 0.99 mg (95% CI: 0.71–1.27) and 0.65 mg (95% CI: 0.36–0.94), respectively. Pooled SMD for HDL was −0.35 mg/dL (95% CI: −0.54 to −0.16), women with GDM had a mean HDL lower than normal pregnant women. Although pooled SMD was higher for low-density lipoprotein (LDL) in the GDM group, this difference was not significant (0.14 [95% CI: −0.04 to 0.32]). Of all the lipid profiles, the largest difference between the GDM and control groups was observed in TG (SMD: 1.14). Elevated serum TG had the strongest effect on GDM. Higher levels of TC, LDL, VLDL, and TG/HDL ratio, and lower level of HDL were exhibited in GDM group. So, these markers can be considered as a reliable marker in the diagnosis of GDM.
Nanostructured silica spin–orbit optics for modal vortex beam shaping
Authors: Coursault Delphine , Brasselet Etienne 
Published: December 2021

AbstractModality is a generic concept of wave-optics at the basis of optical information and communications. One of the challenges of photonics technologies based on optical orbital angular momentum consists in the production of a modal content for both the azimuthal and radial degrees of freedom. This basically requires shaping the complex amplitude of an incident light beam, which is usually made up from adaptive spatial light modulators or bespoke devices. Here, we report on the experimental attempt of a recent theoretical proposal [Opt. Lett.42, 1966 (2017)] toward the production of various optical vortex modes of the Laguerre–Gaussian type relying on the spin–orbit interaction of light. This is done in the visible domain from optical elements made out of silica glass. The idea consists in exploiting the combined effects of azimuthally-varying geometric phase with that of radially-varying propagation features. The proposed approach can be readily extended to any wavelength as well as to other families of optical modes, although some dynamic phase problems remain to be solved to make it a turnkey technology.
Recent advances and prospects for industrial waste management and product recovery for environmental appliances: a review
Authors: Sundramurthy Venkatesa Prabhu , Nithya Thirumullaivoyal G. , Masi Chandran , Gomadurai Chinnasamy , Abda Ebrahim M. 
Published: December 2021

Abstract
Any material when utilized for a required period of time and segment, the leftover residues of those materials are known as waste. Enormous waste is generated during such wear and tear process of materials depending on the usage and functions in a routine lifestyle. Those generated waste when overloaded beyond the capacity of natural recycling processes, would influence the environment and human health. Hence, the waste generated from used materials should be managed according to the environmental impact. Even though wastes are also sometimes rich in organic compounds, nutrients, and energy resources, they are not experimented and managed appropriately. Recently, different feasible techniques are invented and followed to recover and reuse the efficient resources that can create and support sustainable livelihood by creating green economy effects by reducing waste. In this chapter, the emphasis has been given to providing an overview of recent advancements on bio-based waste management and product recoveries such as microbes mediated approaches, biorefineries for waste valorization, and bioenergy from industrial waste.
Tunable nanopillar array on a quartz-fiber tip for surface enhanced Raman scattering (SERS) detection
Authors: Melekhov Evgeny , Penn Tatjana , Weidauer Tobias , Abb Valerius , Kammler Martin , Lechner Alfred 
Published: December 2021

Abstract
In this work, a simple two-step method to create tunable self-assembled three-dimensional nanostructure array-like nanoantennas directly on the tip of an optical quartz glass fiber is described. The structures are prepared by using dry etching of the fiber tip. For the etching process, gold nanoparticles fabricated by thermal dewetting technique were used as template. The structures are applied as sensors for label-free analysis of organic substances in ppb range, such as drug residues in liquid solutions. The measurements are carried out by a portable Raman device with an exchangeable sensor head utilizing the SERS-effect. This method allows in situ applications. In order to characterize the SERS cells, para-thiocresol and diclofenac sodium are used as model substances. For optimization of the substrate performance, different thicknesses of the dewetting-layer (6, 9, 12 nm), different etching times for formation of the pillars (6, 8, 10 and 12 min), and different thicknesses of SERS-metallization (25, 50, 75 nm) of gold and silver are compared. In order to show the applicability of the structure on the tip of a fiber, measurements from the upper side and from the underside of the substrate on quartz plates are compared. Reproducible SERS enhancement factors up to

10

7

{10^{7}}

were achieved.
Sex Differences in BNST and Amygdala Activation by Contextual, Cued, and Unpredictable Threats
Authors: Urien Louise , Bauer Elizabeth P. 
Published: December 2021

AbstractFear and anxiety can be described as emotional and physical responses to predictable and unpredictable threats. While the amygdala is necessary for context and cued fear conditioning, the bed nucleus of the stria terminalis (BNST) is important for anxiety-like behavior and conditioned responses to diffuse and/or unpredictable threats. However, we still lack knowledge about how the BNST and amygdala nuclei act in coordination. Moreover, the incidence of anxiety disorders and posttraumatic stress disorder (PTSD) is substantially higher in women than in men, but most studies of fear conditioning are conducted in male rodents. Here, we asked whether the BNST and the lateral, basal, and central nuclei of the amygdala are active during the expression of fear conditioning in male and female rats using FOS immunohistochemistry. We first show that the BNST is indeed involved in context fear expression in males, but not in females. The lateral amygdala was active in both sexes during context fear expression. We next trained animals using tone cues paired with an unconditioned stimulus (US), or tone cues which were unpaired with the US, and thus nonpredictive. Females displayed greater fear expression to these unpaired tones than males. FOS was upregulated in both the BNST and the basal amygdala during fear expression to unpaired tones in both sexes. The differential processing of fear responses by males and females highlights the need to acknowledge sex differences in conditioned fear memory.