bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interventions for resilience of breast cancer patients: a systematic review and meta-analysis
Authors: Wang Zhi , Liu Qiu-yue , Zhao Yu-Lei , Xu Xin-Yi , Chen Yan , Cao Wen-Juan , Li Cai-Hong , Min Li-Hua , Mao Xiaorong 
Published: May 2021

Abstract
Background﻿Breast cancer has now overtaken lung cancer as the world’s mostly commonly-diagnosed cancer. With the increasing prevalence of breast cancer, the psychological problems of breast cancer patients have also received more and more attention from scholars. The aim of our study was to synthesis the available research evidence on the effectiveness of interventions designed to promote or enhance the resilience of breast cancer patients.MethodsWe performed a systematic and comprehensive search of 12 databases from inception to February 4,2021: Web of Science, PubMed, Embase, MEDLINE, Scopus, Cochrane Library, CINAHL, PsycINFO, Chinese National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBM), WanFang and VIP. We conducted a comprehensive qualification screening of the retrieved records and analysed all the included data using Review Manager Version 5.3 and STATA/SE Version 15.1.ResultsA total of 23 RCTs involving 2,002 women with stage I-Ⅳ breast cancer met the eligibility criteria and 15 of them were included in the meta-analysis. The results showed that the effectiveness of resilience training program (SMD = 0.89; 95% CI 0.54, 1.24; p < 0.00001), health education delivered via mobile devices (SMD = 1.84; 95% CI 0.86, 2.82; p = 0.0002) and peer support (SMD = 2.62; 95% CI 0.61, 4.63; p = 0.01) in the experimental groups was better than that of the control groups. Furthermore, there were seven other kind of interventions which might contribute to improve resilience but with very few evidences available.Conclusion﻿Our findings suggest that resilience training program, health education delivered via mobile devices and peer support are more effective than that of the routine nursing care in improving the resilience of breast cancer patients. In addition, this study cannot draw definitive conclusions regarding the effectiveness of other seven kind of interventions because the sample size in the included is small and cannot be conducted in the meta-analysis. More studies are needed in the future to clarify the effectiveness of these interventions.
Identification of Hub Genes and Pathways in Colitis-Associated Colon Cancer by Integrated Bioinformatic Analysis
Authors: Yao Jie , Liu Huang , Wang Peng , Sheng Wenzhi , Huang Yongming 
Published: May 2021

Abstract
Background

Colon cancer is the third leading cause of death in the world. According to the etiology, colon cancer can be divided into three categories: sporadic, hereditary, and colitis-associated colon cancer(CAC). In terms of clinical features, CAC patients have younger age of onset, more multiple lesions, more difficult to find under endoscope, stronger tumor invasiveness than sporadic colorectal cancer patients. Early detection of CAC by endoscopic monitoring is a challenge, and the incidence of septal colorectal cancer is still high. So it is indispensable to find the biomarkers to predict tumorigenesis of CAC.
Methods

The gene expression profiles of GSE43338 and GSE4904 were downloaded from Gene Expression Omnibus (GEO) database. The Limma package was used to standardize the data and obtain differentially expressed genes (DEGs). Protein-protein interaction (PPI) network was evaluated by STRING database. The Cytoscape software was used to establish PPI network and to perform modular analysis. Functional annotation analysis were performed by the DAVID. The transcription factor (TF) and miRNAs that regulate genes expression were analyzed by using the Network Analyst algorithm. Expression correlation analysis were conducted in GEPIA. The prognostic analysis of hub genes were conducted based on TCGA samples.
Results

A total of 275 DEGs including 103 up-regulated genes and 172 down-regulated genes were identified by bioinformatics analysis in CAC. IGF1, BMP4, SPP1, APOB, CCND1, CD44, PTGS2, CFTR, BMP2, KLF4, TLR2 were identified as hub DEGs, which were significantly enriched in PI3K-Akt signaling pathway, stem cell pluripotency regulation pathway, Focal adhesion-Hippo signal pathway and AMPK signal pathway respectively. The FOXC1 were crucial regulators for these hub gene according to the TF analysis. The Sankey diagram showed that both PI3K-AKT signal pathway and Focal adhesion were composed of up-regulated genes, such as SPP1, CD44, TLR2, CCND1, IGF1, which were related to core miRNAs, hsa-mir-16-5p, hsa-mir-129-2-3p and hsa-mir-37a-3p by research and prediction. Survival analysis showed that the differential expression of SPP1, CFRT and KLF4 was significantly related to the poor prognosis of CAC.
Conclusion

This study provided a novel way to illuminate the mechanism of colitis-associated colon cancer. The most of all, the hub genes and signaling pathways may contribute to the prevention, diagnosis and treatment of CAC.
Severe Abdominal Pain as a Presentation of Lead Poisoning: a Case Report
Authors: Ge Wei , Shao Li-hua , Gong Hai-yan , Chen Gang 
Published: May 2021

Abstract
Background: Lead poisoning is a rare but serious disease. The clinical manifestations of lead poisoning are various and nonspecific such as abdominal pain, headache, dizziness, nightmare, fatigue and so on. Rapid diagnosis of lead poisoning is challenging because it does not have special symptoms and the morbidity is very low.Case presentation: A 31-year-old woman presented with epigastric discomfort without any obvious cause. The patient was diagnosed with lead poisoning, as the blood levels of heavy metals were detected and the lead was 463.17ug/L, which was very high (normal value was less than 100 ug/L). The patient was treated with intravenous drip of calcium sodium edentate and got better. The patient achieved good recovery and there was no recurrence.Conclusion: Lead poisoning is a rare disease and easy to be misdiagnosed as acute abdomen disease when present with abdominal pain. Lead poisoning should be considered when common causes of abdominal pain are excluded, especially patients with anemia and abnormal liver function. The diagnosis of lead poisoning is mainly replied on the blood or urine lead concentrations. Then we should firstly cut off the contact with lead and use metal complexing agent to facilitate lead excretion.
Efficacy of PD-1/PD-L1 Inhibitors in Ovarian Cancer: A Single-arm Meta-analysis
Authors: Zhu Jue , Yan Lifeng , Wang Qiming 
Published: May 2021

Abstract
Several studies have evaluated the efficacy of PD-1/PD-L1 inhibitors in ovarian cancer; however, the response rate varies. This study aims to explore the efficacy of anti-PD-1/PD-L1 therapy in ovarian cancer. A quantitative meta-analysis was performed through a systematic search in PubMed, Web of Science, and the Cochrane Library. The pooled ORR was calculated and compared. Fifteen trials were included in this meta-analysis. Our analyses showed that the pooled ORR of all included studies was 19% (95% CI: 13%, 27%). Single PD-1/PD-L1 inhibitors had the lowest ORR of 9% (95% CI: 7%, 12%), while the combination of PD-1/PD-L1 inhibitors and chemotherapy had the highest ORR of 36% (95% CI: 24%, 51%). This study showed that PD-1/PD-L1 inhibitors alone have limited efficacy for ovarian cancer. The combination of PD-1/PD-L1 inhibitors and chemotherapy could be chosen as the recommended modality for further study.
Development and validation of a nomogram to predict Bladder cancer in patients with different metastasis: a SEER database analysis
Authors: Lin Weijian , Xiao Ning , Long Yongfu , Tang Qi , Zhu Sheng , Jin Bin , Xin Zexiang , Tang Rongyu 
Published: May 2021

Abstract
Purpose: Population-based data on the clinical correlates and prognostic value of the pattern of metastases among patients with bladder cancer are needed.

Patients and methods: Surveillance , epidemiology and end results(SEER)database has been explored through SEER program. For each of four distant metastatic sites (bone, brain, liver, lung ),relevant correlation with baseline characteristics were reported. Survival analysis has been conducted through Kaplan-Meier analysis , and multivariate analysis has been conducted through a cox proportional hazard model. The precision of the nomogram was evaluated and compared using concordance index(C-index),and the area under receiver operating characteristic curve(AUC).

Results: A total 2715 patients with metastatic bladder cancer were identidied from 2005-2019.Patients with medium risk have the best overall survival,followed by patients with low risk followed by patients with high risk metastases. Multivariate analysis showed that patients who were older than 80 at the time of diagnosis, single, no Chemotherapy, no complete cystectomy and bone metastases were associated with poor survival. A nomogram based on 7 independent risk factors has a good predictive power for the 12-month, 24-month and 36-month prognosis of patients with bladder cancer. The C index of the nomogram has high consistency in evaluating the survival rate of bladder cancer patients(C index=0.722,95% CI=0.712-0.732).The values of AUC for 12-month, 24-month, and 36-month were 0.775, 0.73, and 0.692.Conclusion: Build Nomogram prediction method validation of bladder tumor, according to the results of the Nomogram has good capability of identification and correction, suggests that these column chart.
The oviposition cue indole inhibits animal-host attraction in Aedes aegypti mosquitoes
Authors: Dekel Amir , Sar-Shalom Evyatar , Yakir Esther , Bohbot Jonathan Daniel 
Published: May 2021

Abstract
Mosquitoes represent a major source of disease transmission and possess the uncanny ability to locate suitable animal-hosts, a feature mediated by their exquisite olfactory system. Insect repellents such as N,N-Diethyl-meta-toluamide, also called DEET, have been shown to activate and inhibit mosquito odorant receptors resulting in behavioral modulation. This and other repellents available for personal protection against mosquitoes are topically applied on the skin and operate at short range. In our search for potential long-range odorant repellents, we have hypothesized that the shared chemical similarities between indole and DEET, may confer the former the ability to block odorant receptor function and inhibit human-host attraction. Using the two-electrode voltage clamp of Xenopus laevis oocytes as a pharmacological platform, we provide evidence that indole inhibits the Aedes aegypti (R)-1-octen-3-ol receptor OR8, a receptor involved in the decision of female mosquitoes to identify human hosts. Coincidentally, we also show that indole inhibits the animal-host seeking behavior of female Aedes aegypti. Together, our findings suggests that indole may be a candidate spatial repellent for the long-range protection of humans against mosquito bites.
Contribution of Agriculture, Forestry, and Other Land Use to Climatic Phenomena Through GHG Emissions in Burundi. Empirical Evidence From the ARDL Approach
Authors: Baptiste Aboyitungiye Jean , Suryanto Suryanto , Gravitiani Evi , Arnaud Nindamutsa , Eric Ngezahayo 
Published: May 2021

Abstract
In a world where we live in a climatic hazard disaster, understanding human activities' impact on the environment becomes crucial, especially for developing countries. This study addresses this issue through the prism of carbon dioxide emissions (CO2) by examining how the growth of agricultural, forestry, and other land-use activities affects the environment. This study examines the long-term relationship between CO2 emissions and agriculture, forestry, and other land use by introducing other explanatory variables such as income per capita and population for 1970-2016. The econometric analysis results confirm a positive long-term relationship between CO2 emissions and agriculture, forestry, and other land use. The Granger causality tests show that this relationship's direction goes from agriculture, forestry, and other land use to CO2 emissions. For a developing country like Burundi, it is the growth of agricultural, forestry, and other land-use activities that determine GHG emissions level and not the other way around. Moreover, the ARDL model results adopted in this study validate our hypothesis, which assumes that Burundi has not yet reached its turning point in CO2 emissions due to economic growth. A low-carbon policy in favor of the environment can be implemented, and this cannot risk any negative repercussions on economic growth.
Outcomes in Pulmonary Sarcoidosis: Results of a Newly Implemented Prednisone Protocol.
Authors: Kampstra Nynke A. , Wees Philip J. van der , Beek Frouke T. van , Biesma Douwe H. , Grutters Jan C. , Nat Paul B. van der 
Published: May 2021

Abstract
Background

Prednisone is used as first-line therapy for patients with pulmonary sarcoidosis. There is however no clear association between prednisone dose and FVC change in patients with pulmonary sarcoidosis. In order to improve our standard of care we introduced a more conservative prednisone protocol.
Methods

This study is a single centre observational non-inferiority study. In the new protocol, prednisone intake was reduced from a starting dose of 40 mg to a starting dose of 20 mg and was introduced on the 1st of September 2017. Primary outcomes evaluated were FVC % predicted, FEV1 % predicted and DLCO % predicted. The secondary outcome measure was BMI.
Results

369 patients were included in the old-cohort (Sept. 2015 – Sept. 2017) and 215 in the new-cohort (Oct. 2017 – Sept. 2019). In the old-cohort, 182 (49.0%) of the patients were treated with prednisone. In total, 114 patients (62.6%) were treated according to the old protocol with a mean initial prednisone dose of 32.1 ± 14.2 mg. In the new-cohort, 93 patients (45.0%) were treated with prednisone of which 53 patients (57.0%) received prednisone according to the new protocol. The mean initial prednisone dose in the new-cohort was 21.4 ± 9.8 mg. Changes in FVC and FEV1 % predicted did not vary. Change in % predicted DLCO was 2.4 ± 9.3 for the old-cohort and − 1.3 ± 11.4 for the new-cohort (p = 0.01). No statistically significant changes in BMI were observed.
Conclusions

Our results indicate that in more than half of the patients the new protocol was followed. The new protocol with reduced prednisone intake seems non-inferior compared to the old prednisone protocol looking at the changes in pulmonary function and BMI. We have shown that applying VBHC principles in a sarcoidosis centre can promote the delivery of high-value clinical care.
Epigenetics and Prognostic Survival Analysis of Muc Gene Family in Breast Cancer Based on Bioinformatics Analysis
Authors: Yang Kai , Cao Xin-Hui , Liang Ming-Xing , Xu Di , Fei Yin-Jiao , Liu Zhen , Chen Xiu , Tang jinhai 
Published: May 2021

Abstract
Background: To explore the epigenetic and biological functions of muc members in breast cancer. Results: Mutation analysis showed that most of the muc members had missense mutations and the breast cancer patients with muc13 had a poor prognosis. Methylation analysis showed that the methylation expression of muc1, muc4, muc5AC and muc13 was related closely. The differentially expressed muc1, muc13 and muc15 had a poor prognosis and were related to immune infiltrating lymphocytes in breast cancer microenvironment. Conclusions: The epigenetic basis and biological functions of muc members are closely related to the occurrence and development of breast cancer.
The effect of cattle-administered ivermectin and fipronil on the mortality and fecundity of Anopheles arabiensis Patton.
Authors: Makhanthisa Takalani Irene , Braack Leo , Lutermann Heike 
Published: May 2021

Abstract
Background

Malaria control primarily depends on two vector control strategies; indoor residual spraying (IRS) and long-lasting insecticide-treated nets (LLIN). Both IRS and LLIN target indoor-biting mosquitoes. However, some of the most important malaria vectors have developed resistance against the chemical compounds used in IRS and LLIN’s. Insecticides-induced behavioural changes in vectors, such as increased outdoor feeding on cattle and other animals also limit the effectiveness of these strategies. Novel vector control strategies must therefore be found to complement IRS and LLIN’s. A promising tool is the use of cattle-applied endectocides. Endectocides are broad-spectrum systemic drugs effective against a range of internal nematodes parasites and blood-feeding arthropods. The aim of this study was to investigate the effect of two endectocide drugs, ivermectin and fipronil, on the survival and fecundity of zoophilic Anopheles arabiensis.
Methods

Laboratory-reared mosquitoes were allowed to feed on cattle treated with either ivermectin (0.2 mg/kg), fipronil (1.0 mg/kg) or saline (Control) on day 0, 1, 4, 7, 13, 21 and 25 post-treatment and mortality and egg production were recorded daily.
Results

Compared to controls, the mortality of An. arabiensis increased 3.52 and 2.43 times with ivermectin and fipronil, respectively. The overall fecundity of mosquitoes that fed on both ivermectin- and fipronil-treated cattle was significantly reduced by up to 90% and 60%, respectively, compared to the control group. The effects of both drugs attenuated over a period of 3 weeks. Ivermectin was more effective than fipronil and increased mosquito mortality by a risk factor of 1.51 higher than fipronil. Similarly, both drugs significantly reduced the fecundity of An. Arabiensis.
Conclusions

This study demonstrated that ivermectin and fipronil are able to suppress An. arabiensis density and could help to reduce outdoor malaria transmission. The data from the current study as well as other similar studies suggest that current-generation endectocides have limited-duration action and are expensive. However, new-generation sustained-release formulations of ivermectin have multi-week high mortality impact on vector populations, thus holding promise of effective reduction of outdoor malaria transmission.
Circusp34 Promotes Osteosarcoma Proliferation and Invasion by Sponging Mir-16-5p: An in Vivo and in Vitro Analysis
Authors: Lou Jingbing , Zhang Hongliang , Xu Jiuhui , Wang Boyang , Ren Tingting , Huang Yi , Tang Xiaodong , Guo Wei 
Published: May 2021

Abstract
Background

Osteosarcoma (OS) is a primary and highly malignant mesenchymal tissue tumor. Although it has achieved a significant breakthrough in therapeutic administration, the specific pathological mechanism remains unclear. CircRNAs are a type of covalently circular RNA with a head-to-tail junction site. Several studies have reported that abnormal expression of circRNAs is closely associated with tumorigenesis and progression. CircRNAs promote or inhibit the progression of OS by sponging miRNAs. In this study, we aimed to investigate the endogenous competition between circRNAs and miRNAs in OS.
Methods

CircUSP34 expression was detected by qRT-PCR in KHOS and 143B cells. To confirm the effect of circRNAs and miRNAs, function assays including CCK8, EdU, wound healing, transwell, and western blot were performed in OS cells. FISH and dual-luciferase reporter assays were performed to confirm the sponging mechanism of circUSP34 and miR-16-5p. Additionally, qRT-PCR, immunohistochemistry, HE staining, and western blot were used to confirm the expression of proteins and genes in tumor tissues from mice.
Results

In the present study, we found that circUSP34 promoted OS proliferation, migration, and invasion in vitro and in vivo. circUSP34 and miR-16-5p were upregulated and downregulated, respectively, in OS cells. OS cells’ biological behaviors, such as proliferation, migration, and invasion, were inhibited after circUSP34 knockdown. Western blot results also showed that Vimentin and Ki-67 expression levels were decreased. Similarly, miR-16-5p mimic compromised OS cell proliferation and migration. FISH assay indicated that circUSP34 and miR-16-5p were colocalized in the cytoplasm. The dual-luciferase reporter assay showed that miR-16-5p was sponged by circUSP34. Interestingly, the miR-16-5p mimic partly reversed the inhibitory effect of sh-circUSP34 on the malignancy of OS cells. Finally, animal experiment results about IHC indicated that Vimentin, N-cadherin, and Ki-67 protein expression decreased, but E-cadherin protein expression increased.
Conclusion

Collectively, circUSP34 promoted OS proliferation, migration, and invasion by sponging miR-16-5p. It can serve as a potential therapeutic target and biomarker.
Acute Esotropia During an Adenoviral Keratoconjunctivitis
Authors: Roca Jaime Moya , Lledó-Riquelme Mariola , Campos-Mollo Ezequiel , Porcar-Plana Carmela , Navarro-Hernández Elena , Lledó-Carreres Manuel 
Published: May 2021

Abstract
Background
Acute acquired comitant esotropia (AACE) is a very infrequent subtype of esotropia that has been used to describe a sudden onset of concomitant esotropia with diplopia in adults. Despite the multiple reports carried out its cause is still controversial.
Case presentation:
We describe a case of a young patient who presented an AACE during the course of an adenoviral keratoconjunctivitis. The patient had no history of previous strabismus. As a result of surgery the patient recovered orthotropy.
Conclusion
AACE is a very infrequent strabismus that has been related with many etiologies and that it occurs during a viral infection is extremely rare. We report a case of an acute acquired comitant esotropia during an adenoviral keratoconjunctivitis that has not been published before.
Risk Factors and Outcomes for Multidrug-resistant Gram-negative Bacterial Infection in Adult Patients with Abdominal Surgery Requiring Intensive Care
Authors: Lin Ting-Lung , Chang Po-Hsun , Chen I-Ling , Lai Wei-Hung , Chen Ying-Ju , Li Wei-Feng , Lee Ing-Kit , Wang Chih-Chi 
Published: May 2021

Abstract
Background: Multidrug-resistant (MDR) gram-negative bacterial (GNB) infections remain a significant cause of morbidity and mortality among surgical patients. The objective of our study was to recognize the risk factors for MDR GNB infection in surgical intensive care unit (SICU) patients with abdominal surgery and determine the predictors independently associated with death.Methods: From 2010 to 2017, a retrospective cohort study was conducted among patients with abdominal surgery admitted in SICU. Patients with GNB (MDR and non-MDR) infections were included for analyses. Results: A total of 364 patients with abdominal surgery experienced GNB infections, among them, 117 (32.1%) were MDR GNB infections. Of 133 MDR GNB isolates, the most frequent isolate was Escherichia coli (45.1%). Patients with MDR GNB infection had significantly longer ventilator days and hospital stay, as well as higher 30-day and in-hospital mortality compared to non-MDR GNB patients. Multivariable analysis showed longer length of pre-ICU stay, surgical re-exploration, received anti-pseudo carbapenems and fluoroquinolones, and higher total bilirubin were independent risk factors for the acquisition of MDR GNB infection. Predictors for 30-day mortality among patients with MDR GNB infection were chronic kidney disease, received anti-pseudo carbapenems and inappropriate empirical antimicrobial therapy.Conclusions: This study provides important information about the risk factors for subsequent MDR GNB infection and 30-day mortality among the patients with abdominal surgery. Given the increasingly MDR GNB infection and mortality, implementation of antimicrobial stewardship programs in critical care unit is crucial to reduce MDR pathogens and optimize antimicrobial therapies.