bluuebunny/crossref_metadata_2025_split huggingface dataset:
Firm Behavior in the Face of Severe Weather: Economic Analysis between Probabilistic and Deterministic Warnings
Authors: Howard Seth P. , Klockow-McClain Kim E. , Boehmer Alison P. , Simmons Kevin M. 
Published: March 2021

AbstractTornadoes cause billions of dollars in damage and over 100 fatalities on average annually. Yet, an indirect cost to these storms is found in lost sales and/or lost productivity from responding to over 2000 warnings per year. This project responds to the Weather Research and Forecasting Innovation Act of 2017, H.R. 353, which calls for the use of social and behavioral science to study and improve storm warning systems. Our goal is to provide an analysis of cost avoidance that could accrue from a change to the warning paradigm, particularly to include probabilistic hazard information at storm scales. A survey of nearly 500 firms was conducted in and near the Dallas–Fort Worth metropolitan area asking questions about experience with tornadoes, sources of information for severe weather, expected cost of responding to tornado warnings, and how the firm would respond to either deterministic or probabilistic warnings. We find a dramatic change from deterministic warnings compared to the proposed probabilistic and that a probabilistic information system produces annual cost avoidance in a range of $2.3–$7.6 billion (U.S. dollars) compared to the current deterministic warning paradigm.
Walking and mindfulness improve the exercise capacity of patients with chronic obstructive pulmonary disease: A randomised controlled trial
Authors: Lin Feng-Lien , Yeh Mei-Ling 
Published: March 2021

Objective: To evaluate the effects of mindful walking practice on the exercise capacity of patients with chronic obstructive pulmonary disease (COPD). Design: A randomised controlled trial with four repeated measurements. Setting: Outpatient departments of a medical centre in northern Taiwan. Participants: Patients with mild to severe COPD. Intervention: The control group received usual care, whereas the mindful walking group received usual care plus undertook a mindful walking practice. Outcome measures: The main outcome was the six-minute walk distance. And the Global Initiative for Chronic Obstructive Lung Disease classification, dyspnoea, heart rate variability and interoceptive awareness were control factors. Results: Compared with the control group ( n = 40), the mindful walking group ( n = 38) achieved a significantly longer six-minute walk distance (longer by 45.57 m; P = 0.04). The interaction effect of the six-minute walk distance significantly increased on Week 4 ( P = 0.01), Week 8 ( P = 0.002) and Week 12 ( P = 0.02). Participants in Global Initiative for Chronic Obstructive Lung Disease class A exhibited significantly improved six-minute walk distance compared with those in class D ( P  = 0.001). Moreover, scores on the emotional awareness scale of interoceptive awareness were significantly associated with the six-minute walk distance ( P = 0.02). Conclusion: The eight-week mindful walking practice improved the exercise capacity of patients with COPD, and its effect was sustained for at least four weeks after the end of the practice. This study suggest that this practice improved COPD symptoms, reduced COPD risk and increased the interoceptive awareness of this population.
Collision kidney tumor with clear cell renal cell carcinoma and papillary type 1 renal cell carcinoma. A case report and review of the literature
Authors: Lamprou Stavros , Glykas Ioannis , Fragkoulis Charalampos , Theodoropoulou Georgia , Koutsonikas Georgios , Papadopoulos Georgios 
Published: March 2021

Introduction: The most common renal neoplasms include clear cell, papillary, and chromophobe renal cell carcinomas. The simultaneous occurrence of different histological types of adjacent neoplasms in the same organ is known as a collision tumor. Collision kidney tumors have already been described but only in rare cases. Case description: In this case report we present a 68-year-old man with chronic kidney insufficiency under dialysis who underwent an open right nephrectomy in our department with the histological diagnosis of a collision kidney tumor consisting of clear cell and papillary type 1 renal cell carcinoma. Conclusion: To the best of our knowledge, our case of a collision kidney tumor consisting of clear cell RCC and papillary type 1 RCC, is unique in literature.
Study on the collision dynamics of integral shroud blade for high-pressure turbine in different integral shroud clearance distance
Authors: Zhang Qinglei , Wang Haoyang , Qin Jiyun , Duan Jianguo 
Published: March 2021

In steam turbine, turbine blades are prone to vibrate during operation, resulting in steam turbine accidents. The most common method for reducing the vibration of steam turbine blades is to design an integral shroud for blade which is termed as integral shroud blade. Most previous studies simplified straight integral blades into cantilever beam and used harmonic response analysis method to simulate the vibration response of blades. This method is suitable for simulating straight blade vibration under harmonic force conditions. For twisted blades, accurate results are hard to acquire and the specific collision process cannot be simulated. In order to observe the collision process on a microscopic scale and explore its collision damping mechanism, this study evaluated the collision process of twisted blades with different integral shroud clearance distance based on LS-DYNA software. The collision process for a two-blade system and a three-blade system with integral shroud clearance distance from 0.1 mm to 0.5 mm has been simulated. The results indicated that integral shroud clearance distance have opposite vibration damping effect when the blade under the condition of forced vibration and free vibration. For the two-blade system, the optimal integral shroud clearance distance is 0.4 mm for forced vibration condition and 0.1 mm for free vibration condition. For the three-blade system, the optimal integral shroud clearance distance is 0.1 mm for forced vibration condition and 0.5 mm for free vibration condition.
The role of perceived loneliness and sociodemographic factors in association with subjective mental and physical health and well-being in Norwegian adolescents
Authors: Moksnes Unni K. , Bjørnsen Hanne N. , B. Eilertsen Mary-Elizabeth , Espnes Geir Arild 
Published: March 2021

Aims: Adolescence is a particularly salient period for understanding the role of perceived loneliness for subjective health and well-being. This study investigated sociodemographic differences (sex, age, self-reported socio-economic status (SES)) in loneliness and associations between sociodemographic factors, loneliness and self-rated health (SRH), subjective health symptoms, symptoms of depression/anxiety and mental well-being (MWB) in a sample of Norwegian adolescents. Methods: The study was based on a cross-sectional sample of 1816 adolescents aged 15–21 years. The participants reported scores on an 11-item scale assessing subjective health complaints (SHC), one item each assessing SRH and loneliness, the 10-item version of the Hopkins Symptom Checklist and the seven-item version of the Warwick–Edinburgh Mental Well-Being Scale. SES was assessed using perceived family economy and parents’ education. Data were analysed with descriptive, comparative and multiple linear regression analyses. Results: The multivariate results showed that boys scored significantly higher on MWB than girls did, whereas girls scored significantly higher on loneliness, depression/anxiety and SHC. Perceptions of poorer family finances were significantly associated with higher levels of SHC and depression/anxiety, lower levels of MWB and more negative SRH. Loneliness showed significant positive associations with depression/anxiety and SHC, and significant negative associations with MWB and SRH. A significant moderation effect of sex by loneliness was found in association with depression/anxiety, with stronger associations for girls. Conclusions: The findings in this study support the significant roles of sex, perceptions of family finances and loneliness in association with adolescent’s subjective mental and physical health and well-being, especially mental health.
Spouse and Child Abuse Associated With Illicit Drug Use in Iran: A Systematic Review and Meta-Analysis
Authors: Baheshmat Shahab , Gholami Jaleh , Amin-Esmaeili Masoumeh , Shadloo Behrang , Rahimi-Movaghar Afarin 
Published: March 2021

Background: There is a high prevalence of substance use disorders, especially among men, in Iran and is associated with a high burden on families. We aimed to systematically review the association between illicit drug use and spouse and child abuse in Iran. Method: Comprehensive terms were used to search three international databases (ISI, Medline, and Scopus) and a national database of Scientific Information Database up to September 2019. The retrieved citations were screened based on the eligibility criteria and then data were extracted, and the risk of bias was assessed by two independent investigators. Data were analyzed using random-effects model to estimate pooled odds ratios ( ORs) and the heterogeneity of studies. Results: The search yielded 18 articles that met the inclusion criteria. Illicit substance use in husbands was associated with increased odds of current violence ( OR = 3.50; 95% CI [2.09, 5.86]), current physical violence ( OR = 5.41; 95% CI [3.50, 8.35]), current psychological violence ( OR = 6.20; 95% CI [3.74, 10.30]), and current sexual violence ( OR = 7.23; 95% CI [4.06, 12.87]) against spouse. In studies on child abuse, the odds of current physical child abuse by parents who used an illicit substance was 3.88 times (95% CI [1.50, 10.01]) higher than parents who did not use any illicit substance. Conclusion: The results of the current study showed that illicit substance use is associated with an increased risk of spouse and child abuse. This is an important social and health consequence of drug use and should be addressed in all drug control plans.
Defining abnormal cold sensitivity using the Cold Intolerance Symptom Severity questionnaire: a population study
Authors: Stjernbrandt Albin , Liljelind Ingrid , Nilsson Tohr , Wahlström Jens 
Published: March 2021

Cold sensitivity, a common and disabling sequela of hand injury, can be assessed using the Cold Intolerance Symptom Severity (CISS) questionnaire, rating symptoms on a scale from 4 to 100. The primary objective of this study was to define a clinical cut-off for abnormal cold sensitivity based on the CISS score in a healthy working-age population. The secondary objective was to investigate how age, gender and previous injuries and diseases influence CISS scoring. In this study, 1239 out of 1582 selected healthy subjects of working age living in northern Sweden completed the questionnaire, yielding a response rate of 78%. The 95th percentile for the CISS score was 49.5 for men and 53.0 for women. The effects of age, gender and previous injuries and diseases were minor and not considered clinically relevant. The results support that a CISS score above 50 should be considered as abnormal cold sensitivity. Level of evidence: III
Midterm Functional and Structural Outcomes of Large/Massive Cuff Tears Treated by Arthroscopic Partial Repair
Authors: Moriyama Hiroaki , Gotoh Masafumi , Tanaka Koji , Mitsui Yashuhiro , Nakamura Hidehiro , Ozono Hiroki , Okawa Takahiro , Shiba Naoto 
Published: March 2021

Background: Previous studies have shown good clinical outcomes in patients with irreparable large or massive rotator cuff tears treated using arthroscopic partial repair (APR); however, few studies have evaluated both functional and structural outcomes in these patients. Purpose: To evaluate both functional and structural outcomes in patients with large or massive rotator cuff tears treated using APR. Study Design: Case series; Level of evidence, 4. Methods: Between March 2009 and November 2016, a total of 30 patients underwent APR because of the irreparability of their large or massive rotator cuff tears during surgery. Of these patients, 24 completed the minimum 24-month follow-up (mean, 61.8 ± 27.1 months; range, 24-112 months) and were included in this study. Functional outcome measures included the Japanese Orthopaedic Association (JOA) and University of California Los Angeles (UCLA) scores and the visual analog scale for pain. Structural outcome measures comprised preoperative fatty degeneration, mediolateral tear size, residual tendon attachment area, and glenohumeral (GH) arthritic changes evaluated on magnetic resonance imaging scans or plain radiographs before and after surgery. Functional and structural outcomes were evaluated preoperatively, at 3 months postoperatively, and at the final follow-up. Results: The JOA scores for all patients significantly improved from 67.9 ± 11.3 preoperatively to 85.4 ± 15.6 postoperatively ( P < .0001). Similarly, the UCLA scores significantly improved from 15.8 ± 4.20 preoperatively to 29 ± 6.69 at final follow-up postoperatively ( P < .0001). The mediolateral tear size were significantly decreased at 3 months postoperatively ( P < .001) and at the final follow-up ( P < .001). Compared with preoperative scores, the novel score evaluating the residual tendon attachment area improved from 3.08 ± 0.46 to 3.54 ± 0.41 ( P < .001) after surgery overall, although it significantly deteriorated from 3 months postoperatively to the final follow-up. GH osteoarthritis progressed in 6 patients (25%). Patients who developed osteoarthritis had lower JOA and UCLA scores than did those who did not (JOA, P = .010; UCLA, P = .037). Conclusion: In irreparable large or massive rotator cuff tears treated using APR, functional outcome improved after surgery. Although the residual tendon attachment area improved, functional outcome after APR corresponded to the GH alterations at the midterm follow-up. Longer-term follow-up is needed to further elucidate the effect of APR on clinical outcomes in these patients.
Density Peak clustering of protein sequences associated to a Pfam clan reveals clear similarities and interesting differences with respect to manual family annotation
Authors: Russo Elena Tea , Laio Alessandro , Punta Marco 
Published: March 2021

Abstract
Background
The identification of protein families is of outstanding practical importance for in silico protein annotation and is at the basis of several bioinformatic resources. Pfam is possibly the most well known protein family database, built in many years of work by domain experts with extensive use of manual curation. This approach is generally very accurate, but it is quite time consuming and it may suffer from a bias generated from the hand-curation itself, which is often guided by the available experimental evidence.

Results
We introduce a procedure that aims to identify automatically putative protein families. The procedure is based on Density Peak Clustering and uses as input only local pairwise alignments between protein sequences. In the experiment we present here, we ran the algorithm on about 4000 full-length proteins with at least one domain classified by Pfam as belonging to the Pseudouridine synthase and Archaeosine transglycosylase (PUA) clan. We obtained 71 automatically-generated sequence clusters with at least 100 members. While our clusters were largely consistent with the Pfam classification, showing good overlap with either single or multi-domain Pfam family architectures, we also observed some inconsistencies. The latter were inspected using structural and sequence based evidence, which suggested that the automatic classification captured evolutionary signals reflecting non-trivial features of protein family architectures. Based on this analysis we identified a putative novel pre-PUA domain as well as alternative boundaries for a few PUA or PUA-associated families. As a first indication that our approach was unlikely to be clan-specific, we performed the same analysis on the P53 clan, obtaining comparable results.

Conclusions
The clustering procedure described in this work takes advantage of the information contained in a large set of pairwise alignments and successfully identifies a set of putative families and family architectures in an unsupervised manner. Comparison with the Pfam classification highlights significant overlap and points to interesting differences, suggesting that our new algorithm could have potential in applications related to automatic protein classification. Testing this hypothesis, however, will require further experiments on large and diverse sequence datasets.
Strain-based and sex-biased differences in adrenal and pancreatic gene expression between KK/HlJ and C57BL/6 J mice
Authors: Inglis Angela , Ubungen Rosario , Farooq Sarah , Mata Princess , Thiam Jennifer , Saleh Soad , Shibin Sherin , Al-Mohanna Futwan A. , Collison Kate S. 
Published: March 2021

Abstract
Background
The ever-increasing prevalence of diabetes and associated comorbidities serves to highlight the necessity of biologically relevant small-animal models to investigate its etiology, pathology and treatment. Although the C57BL/6 J model is amongst the most widely used mouse model due to its susceptibility to diet-induced obesity (DIO), there are a number of limitations namely [1] that unambiguous fasting hyperglycemia can only be achieved via dietary manipulation and/or chemical ablation of the pancreatic beta cells. [2] Heterogeneity in the obesogenic effects of hypercaloric feeding has been noted, together with sex-dependent differences, with males being more responsive. The KK mouse strain has been used to study aspects of the metabolic syndrome and prediabetes. We recently conducted a study which characterized the differences in male and female glucocentric parameters between the KK/HlJ and C57BL/6 J strains as well as diabetes-related behavioral differences (Inglis et al. 2019). In the present study, we further characterize these models by examining strain- and sex-dependent differences in pancreatic and adrenal gene expression using Affymetrix microarray together with endocrine-associated serum analysis.

Results
In addition to strain-associated differences in insulin tolerance, we found significant elevations in KK/HlJ mouse serum leptin, insulin and aldosterone. Additionally, glucagon and corticosterone were elevated in female mice of both strains. Using 2-factor ANOVA and a significance level set at 0.05, we identified 10,269 pancreatic and 10,338 adrenal genes with an intensity cut-off of ≥2.0 for all 4 experimental groups. In the pancreas, gene expression upregulated in the KK/HlJ strain related to increased insulin secretory granule biofunction and pancreatic hyperplasia, whereas ontology of upregulated adrenal differentially expressed genes (DEGs) related to cell signaling and neurotransmission. We established a network of functionally related DEGs commonly upregulated in both endocrine tissues of KK/HlJ mice which included the genes coding for endocrine secretory vesicle biogenesis and regulation: PCSK2, PCSK1N, SCG5, PTPRN, CHGB and APLP1. We also identified genes with sex-biased expression common to both strains and tissues including the paternally expressed imprint gene neuronatin.

Conclusion
Our novel results have further characterized the commonalities and diversities of pancreatic and adrenal gene expression between the KK/HlJ and C57BL/6 J strains as well as differences in serum markers of endocrine physiology.
Epidemiological risk factors and the geographical distribution of eight Mycobacterium species
Authors: Donohue Maura J. 
Published: March 2021

Abstract
Background
Nontuberculous mycobacteria (NTM) are environmental bacterium that may cause and/or compound respiratory diseases in humans. There are over a hundred NTM species with varying pathogenicity’s Therefore, it is necessary to characterize the populations at risk for each species.

Methods
Demographic (age, sex, and state of residence) and microbiological data from 2014 were extracted from Mississippi, Missouri, and Ohio disease surveillance systems. NTM species with > 50 reports were included in the analysis. Patient sex, age, and incidence rates were generated for each of the following NTM species: M. abscessus, M. avium complex (MAC), M. chelonae, M. fortuitum, M. gordonae, M. kansasii, M. mucogenicum, and M. peregrinum.

Results
Analysis by sex showed that M. chelonae,M. fortuitum, M. gordonae,and M. kansasii had significantly higher rates in males than females. Age was not associated with patient rates for several specific NTM species e.g., M. chelonae. Mississippi had the highest patient’ rates for M. avium, M. gordonae, M. kansasii, and M. chelonae. Ohio had the highest patient’ rates for M. abscessus, M. mucogenicum, and M. peregrinum. The highest patient’s rate for M. fortuitum was observed in Missouri.

Conclusion
This study showed that NTM infection occurred more frequently in males. The highest rates were observed in Mississippi for most of the NTMs studied. Age was not a strong risk factor for some of the NTM species.
Peritoneal dialysis-associated peritonitis caused by Mycobacteroides massiliense: the first case and review of the literature
Authors: Hamada Shintaro , Takata Tomoaki , Kitaura Tsuyoshi , Teraoka Chiori , Aono Akio , Taniguchi Sosuke , Mae Yukari , Isomoto Hajime , Chikumi Hiroki , Mitarai Satoshi 
Published: March 2021

Abstract
Background
Peritoneal dialysis (PD)-associated peritonitis caused by nontuberculous Mycobacterium is rare; however, the number of cases has increased over the past decades. Mycobacteroides massiliense is a subspecies of the Mycobacteroides abscessus complex. It has different clinical characteristics compared to the other subspecies of the complex. Previous case reports of PD-associated peritonitis caused by Mycobacteroides abscessus complex have not distinguished the subspecies in detail.

Case presentation
A 40-year-old man presented with an exit-site and tunnel infection refractory to antibiotic therapy. Peritonitis occurred after simultaneous catheter removal and reinsertion. The Mycobacteroides abscessus complex was detected in the culture of the dialysis effluent. Removal of the PD catheter combined with antibiotics, including macrolides, resulted in a good clinical course. Further analysis of multiplex PCR and the hsp65 gene sequence identified the bacterium as Mycobacteroides massiliense.

Conclusions
The Mycobacteroides abscessus complex is classified into three subspecies; Mycobacteroides abscessus, Mycobacteroides massiliense, and Mycobacteroides bolletii. These have different characteristics, particularly antibiotic susceptibility. Therefore, clear identification of the subspecies of the Mycobacteroides abscessus complex is necessary for definitive treatment.