bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Admission Serum Phosphate and Risk of Acute Kidney Injury in Critically Ill Patients with Rhabdomyolysis: A Retrospective Study Based on MIMIC-III
Authors: Wen Tao , Mao Zhi , Liu Chao , Wang Xiaoli , Zhou Feihu 
Published: November 2021

Abstract
Background The incidence of acute kidney injury(AKI) is high in critically ill patients with rhabdomyolysis. Limited evidence was proved of the association between serum phosphate levels at intensive care unit(ICU) admission and the subsequent risk of AKI. Our study aims to assess if serum phosphate level at admission was independently associated with AKI risk in these patients. Methods This study extracted and analyzed data from Medical Information Mart for Intensive Care-Ⅲ(MIMIC-Ⅲ,version1.4). Rhabdomyolysis was defined as a peak creatine kinase(CK) level higher than 1000 U/L. Serum phosphate was measured within the first day into the ICU and was categorized to 4 groups(<2.6, 2.6-3.4, 3.5-4.5, >4.5mg/dl). AKI was defined according to the Kidney Disease Improving Global Outcome (KDIGO) guidelines. Adjusted smoothing spline plots and multivariate logistic regressions were carried out to explode the association between serum phosphate and risk of AKI. Subgroup analyse was applied to verify the consistency of the association.Results Three hundred and twenty-one patients(67.8% male) diagnosed as rhabdomyolysis were eligible for this analysis. AKI occurred in 204(63.6%) patients of total. Incidence of AKI with admission serum phosphate groups<2.6, 2.6-3.4, 3.5-4.5 and>4.5mg/dl were 52.6%, 56.8%, 68.4% and 75.9%, respectively. Smoothing spline curve showed that there was a positive curve between the elevated phosphate values and increasing risk of AKI, and there was no threshold saturation effect. In multivariate logistic regression, OR was 1.3(95%CI 1.1-1.6, P=0.012, P trend=0.034) after adjusting confounders. Subgroup analyses proved the consistency of the relationship in these patients except in the strata of creatine kinase.Conclusion In rhabdomyolysis patients admitted to ICU, serum phosphate level at admission was independently associated with an increased risk of AKI. As phosphate levels rise, the risk of AKI increased.
Modeling of mechanism of obtaining mesostructural coal matrix in pyrolysis processes.
Authors: Kotelnikov Valeriy , Ryazanova Elena , Ershova Olesya 
Published: November 2021

Abstract
Reducing the role of coal in the energy balance of countries and the whole world sets the task of improving coal combustion technologies and creating new environmentally friendly processes for deep processing of coal. The production of high-quality raw materials for the metallurgical industry and other industries is a strategic task for the development of the country. In this study we try to use an Monte Carlo method to analyze and modeling of coke producing process in the device for continuous pyrolysis of organic materials in a thermally loaded layer.
Accelerated Hyper-Versus Normofractionated Radiochemotherapy with Temozolomide in Patients with Glioblastoma: A Multicenter Retrospective Analysis.
Authors: Klement Rainer J. , Popp Ilinca , Kaul David , Ehret Felix , Grosu Anca L. , Polat Bülent , Sweeney Reinhart A. , Lewitzki Victor 
Published: November 2021

Abstract
Background and purpose
The standard treatment of glioblastoma (GB) patients consists of surgery followed by normofractionated radiotherapy (NFRT) with concomitant and adjuvant temozolomide chemotherapy. Whether accelerated hyperfractionated radiotherapy (HFRT) yields comparable results to NFRT in combination with temozolomide has only sparsely been investigated. The objective of this study was to compare NFRT with HFRT in a multicenter analysis.
Materials and methods
A total of 484 GB patients from four centers were retrospectively pooled and analyzed. 310 and 174 patients had been treated with NFRT (30×1.8Gy or 30×2Gy) and HFRT (37×1.6Gy or 30×1.8Gy twice/day), respectively. The primary outcome of interest was overall survival (OS) which was correlated with patient-, tumor- and treatment-related variables via univariable and multivariable Cox frailty models. For multivariable modeling, missing covariates were imputed using multiple imputation by chained equations, and a sensitivity analysis was performed on the complete-cases-only dataset.
Results
After a median follow-up of 15.7 months (range 0.8-88.6 months), median OS was 16.9 months (15.0-18.7 months) in the NFRT group and 14.9 months (13.2-17.3 months) in the HFRT group (p=0.26). In multivariable frailty regression, better performance status, complete versus not complete resection, MGMT hypermethylation, IDH mutation, smaller planning target volume, no steroid administration, and salvage therapy were significantly associated with longer OS (all p<0.01). Treatment differences (HFRT versus NFRT) had no significant effect on OS in either univariable or multivariable analysis.
Conclusions
This analysis suggests that HFRT and temozolomide is a safe option for patients wishing to shorten their treatment time and does not affect OS.
Ab initio mechanism revealing for tricalcium silicate dissolution
Authors: Li Yunjian , Pan Hui , Ming Xing , Li Zongjin 
Published: November 2021

Abstract
Dissolution of mineral in water is ubiquitous in nature and industry, especially for the calcium silicate species. However, the behavior of such a complex chemical reaction is still unclear at atomic level. Here, we show that the ab initio molecular dynamics and metadynamics simulations enable quantitative analyses of reaction pathways, and the thermodynamics and kinetics of calcium ion dissolution from the tricalcium silicate (Ca3SiO5) surface. The calcium sites with different coordination environment leads to different reaction pathways and free energy barriers. The low free energy barriers lead to that the detachment of calcium ions is a ligand exchange and auto-catalytic process. Moreover, the water adsorption, proton exchange and diffusion of water into the surface layer accelerate the leaching of calcium ions from the surface step by step. The discovery in this work thus would be a landmark for revealing the mechanism of cement hydration.
Construction of Pharmacological Network and Molecular Docking Analysis of Key Molecular Components of Jianpi Yiqi Formula for Idiopathic Thrombocytopenic Purpura
Authors: Li Qiming , Deng Gang , He Yunlei , Yang Jiafeng 
Published: November 2021

Abstract
Purpose: To perform network pharmacological analysis so as to identify and screen the active ingredients of Jianpi Yiqi Formula; find its core target and explore its mechanism in the treatment of idiopathic thrombocytopenic purpura (ITP). Materials and Methods: A network pharmacology approach was used to inquire and screen the active ingredients from the Traditional Chinese Medicine System Pharmacology (TCMSP) database for potential active compounds that are commonly contained in the Jianpi Yiqi formula. The Swiss Target Prediction database was used for the prediction of the active ingredient's target of the action; the genecard database was used to search for target genes associated with ITP and to screen for target genes, in which the drug target was intersected with the disease target. Protein interaction network was constructed using string database software for GO and KEGG analysis to construct the "component/target/pathway" pharmacology network of Jianpi Yiqi granules therapy for ITP. Cytoscape 3.7.2 software was harnessed to visualize and integrate this network. The Virtua Drug web-based pharmacology website ( https://www.dockingserver.com ) was used to validate the regulatory relationship between key active compounds and critical pathway molecular signals by molecular docking. Results: Two key active ingredients, quercetin, and kaempferol, were selected from hundreds of herbal ingredients referenced in online pharmacological studies. Molecular docking analysis revealed that quercetin and kaempferol could stably bind PI3K/AKT and exert inhibitory effects, respectively. It was also speculated that PI3K/AKT/mTOR pathway might be the critical pathway for the pharmacokinetic mechanism of Jianpi Yiqi Granules. Conclusion: The present study suggests the multi-component effect characteristic of the treatment of ITP with Jianpi Yiqi granules, thus providing a theoretical basis for the clinical use of Jianpi Yiqi formula.
Biopsychosocial risk factors of depression during menopause transition in southeast China
Authors: Chu Ketan , Shui Jing , Ma Linjuan , Huang Yizhou , Wu Fan , Wei Fang , Meng Xingjun , Luo Jie , Ruan Fei , Zhou Jianhong 
Published: November 2021

Abstract
Objective

More than 2 billion women experiencing menopause transition in China and some of them suffered depression; while the risk factors of depression are still unclearin China. We aimed to investigate the risk factors in mid-life women in Southeast China.
Method

This study included 1748 Chinese women aged 40 to 65 years who visit gynecology outpatient department of Women’s hospital School of Medicine, Zhejiang University during 2010 to 2018. Demographic information was collected, and the modified Kupperman Menopausal Index (mKMI) and Hamilton Rating Scale for Depression were assessed. Circulating levels of sex hormones were obtained. Ordinal logistic regression analysis was performed to identify risk factors for depression.
Results

The prevalence of depression symptoms was 47.43%. The majority of women had mild (38.56%) or moderate depression symptoms (8.00%); only 0.86% had severe depression. Compared with perimenopausal women, postmenopausal women had increased risks of depression. The associations between menopausal syndromes and depression were strongly positive (OR 6.69, 95% CI 5.39–8.29). Women with older age, higher follicle stimulating hormone levels, lower estradiol levels, and fewer parity had increased risk of depression. Among postmenopausal women, underweight, mKMI > 14, earlier age at menopause, shorter reproductive period, and longer duration after menopause were risk factors for depression.
Conclusions

The results demonstrated a high proportion of depression in women complaining of menopause. Menopausal symptoms were strongly related to the risk of depression. In postmenopausal women, estrogen related events are associated with depression. Gynecological endocrinologists in China should consider screening for depression in high-risk women.
Integrative analysis of proteome-wide association and transcriptome-wide association study identifies candidate brain proteins associated with insomnia
Authors: Meng Peilin , Cheng Bolun , Li Chun’e , Zhang Huijie , Cheng Shiqiang , Liu Li , Yang Xuena , Liang Chujun , Yao Yao , Ye Jing , Chu Xiaomeng , Pan Chuyu , Chen Yujing , Zhang Jingxi , Zhang Zhen , Wen Yan , Jia Yumeng , Guo Xiong , Zhang Feng 
Published: November 2021

Abstract
Great progress has been made in identifying risk loci for insomnia by genome-wide association studies (GWAS) analysis, but its association with human brain proteome is unclear. Two insomnia GWAS summary datasets were derived from deCODE (n = 113,006) and 23andMe (n = 1,331,010). Two human brain proteomic datasets were obtained from ROS/MAP and Banner, and two reference datasets were obtained from brain RNA-seq (CBR) and RNA-seq splicing (CBRS). Proteome-wide association study (PWAS) was first used to detect brain proteins associated with insomnia at the translation level. Transcriptome-wide association study (TWAS) was then used to verify the results at the DNA level. Finally, brain imaging GWAS was used to explore the brain functional areas related to the identified brain proteins and genes in insomnia. PWAS identified 4 and 1 common proteins shared by two human brain proteomic datasets in insomnia GWAS dataset 1 and 2, such as ME1 (PDataset1−Banner−full=1.08×10−2, PDataset1−ROS/MAP−full=8.21×10−3). Further TWAS identified 5 and 1 candidate genes shared by the two reference expression profiles in dataset 1 and 2, like ICA1L (PDataset2−CBR=3.01×10−2, PDataset2−CBRS=3.24×10−2). CAMLG was observed to associate with insomnia in both PWAS (PDataset2−ROS/MAP=2.94×10−2) and TWAS (PDataset2−CBR=1.11×10−2). Comparing the results of PWAS and TWAS, there are 9 common proteins and genes shared by both two datasets, such as INPP4A. Brain imaging analysis found that insomnia associated proteins and genes were functionally related to cortex. Our results may reinforce the understanding of the etiology and pathophysiology of insomnia and provide promising brain protein targets for further therapeutic and mechanistic studies.
Identification of Tumor Specific Neoantigens and Their Implications in Dendritic Cell Immunotherapy Using Liquid Biopsy Results: Findings from an Observational Cohort Study
Authors: Myint Khin Zay Yar , Shimabuku Masamori , Horio Ruriko , Kaneda Munehisa , Shimizu Yoko , Taguchi Junichi 
Published: November 2021

Abstract
Liquid biopsies can be a rapid, cost-effective and noninvasive alternative to tumor biopsies for detecting genetic mutations in somatic tumors. Genetic profiling of liquid biopsies can also be used to identify novel antigens for targeted therapy, provide updated information on disease prognosis and evaluate treatment efficacy. In this study, we aimed to examine mutations that could be identified in liquid biopsy and their potential implications for personalized dendritic cell immunotherapy using neoantigens. We analyzed the genomic profiles of 99 blood samples from 85 patients with 22 different types of cancer using two commercially available liquid biopsy tests before the patients underwent standard cancer treatment and dendritic cell immunotherapy. Nonsynonymous mutations were detected in more than 90% of the samples, with an average frequency of 3.6 mutations per sample. The tumor mutations were specific to each patient, as approximately 94.7% of the mutations were so unique that there was almost no duplication among the patients. Clonal evolution was observed in two patients just before or after chemotherapy, radiotherapy and immunotherapy. These findings indicate that liquid biopsy can be a potential surrogate for neoantigen-based immunotherapy and the importance of tailoring neoantigen-based immunotherapy in accordance with the liquid biopsy result in each treatment stage.
Autocrine Activity of Exosomes in Glucocorticoid-Induced Injury of Bone Microvascular Endothelial Cells Identified by Protein Array
Authors: Zhang Qingyu , Li Tengqi , Li Zirong , Lu Jike , Wu Xinjie , Gao Fuqiang , Sun Wei 
Published: November 2021

Abstract
Background: Glucocorticoid could induce injury and apoptosis of bone microvascular endothelial cells (BMECs) in the femoral head and the application of icariin showed a protective effect. However, the impact of autocrine exosomes during these processes is still to be confirmed.Methods: Exosomes were extracted from BMECs treated with hydrocortisone or hydrocortisone plus icariin by super-speed centrifugation; exosome-carried proteins were evaluated via BCA assay, Western blotting, protein array assay and Elisa test, while miRNA expression profile was assessed via high-throughput sequencing and confirmed by quantitative polymerase chain reaction (qPCR) to screen candidate molecules responsible for BMEC-Exo function. BMECs were incubated with and without exosomes before glucocorticoid intervention and then the impact of BMECs-derived exosomes on BMECs viability, apoptosis, migration, angiogenesis, and protein expression was further assessed by a series of functional assays. Results: Exosomes secreted by BMECs could ameliorate glucocorticoid-induced endothelial cellular injury, improve cell viability, decrease cell apoptosis, and promote cell migration and angiogenesis compared with the blank control. These effects of secreted exosomes could be reinforced by icariin intervention. Meanwhile, mechanism studies showed that expression level of eNOS, COX-2, and pERK were significantly increased while the cleaved caspase-3 level was decreased in BMECs after coculture with exosomes. Although icariin treatment would not significantly change the size and total protein content of BMECs-derived exosomes, expression of exosome-carried vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGF-β1) was enhanced and numerous miRNAs involved in cell proliferation and apoptosis were up-regulated (e.g., hsa-miR-1469 and hsa-miR-133a-5p) or down-regulated (e.g., hsa-miR-10b-5p) (p < 0.05). 29 differentially expressed inflammatory factors were detected between the exosomes secreted by the Icariin-treated and the Model groups.Conclusion: To sum up, the present study indicates that autocrine exosomes could significantly improve glucocorticoid-induced injury of BMECs, partially mediated by activation of MAPK/ERK pathway and regulation of several inflammation/apoptosis/proliferation-associated proteins. Icariin intervention could reinforce these effects and may act as a promising drug for improving glucocorticoid-induced injury of BMECs. In vivo or animal studies are still required to better understand the function of BMEC-derived exosomes.
Incidence, Survival, and Associated Factors Estimation in Osteosarcoma Patients with Lung Metastasis: A Single-center Experience of 11 Years in Tianjin, China
Authors: Zhang Chao , Wu Haixiao , Xu Guijun , Ma Wenjuan , Qi Lisha , Li Zhijun , Zhang Jin 
Published: November 2021

Abstract
Background: Osteosarcoma is the most common primary malignant bone tumor. The current study was conducted to describe the general condition of patients with primary osteosarcoma in a single cancer center in Tianjin, China and to investigate the associated factors in osteosarcoma patients with lung metastasis. Methods: From February 2009 to October 2020, patients from Tianjin Medical University Cancer Institute and Hospital, China were retrospectively analyzed. The Kaplan–Meier method was used to evaluate the overall survival of osteosarcoma patients. Prognostic factors of patients with osteosarcoma were identified by the Cox proportional hazard regression analysis. Risk factor of lung metastasis in osteosarcoma were investigated by the logistic regression model. Results: A total of 203 patients were involved and 150 patients were successfully followed up for survival status. The 5-year survival rate of osteo-sarcoma patients was 70.0%. Surgery, bone and lung metastasis were the significant prognostic factors in multivariable Cox regression analysis. Twenty-one (10.3%) patients showed lung metastasis at the diagnosis of osteosarcoma and 67 (33%) lung metastases during the later course. T3 stage (OR=11.415, 95%CI 1.362-95.677, P=0.025) and synchronous bone metastasis (OR=6.437, 95%CI 1.69-24.51, P=0.006) were risk factors of synchronous lung metastasis occurrence. Good necrosis (≥90%, OR=0.097, 95%CI 0.028-0.332, P=0.000) and elevated Ki-67 (≥50%, OR=4.529, 95%CI 1.241-16.524, P=0.022) were proved to be significantly associated with metachronous lung metastasis occurrence. Conclusion: The overall survival, prognostic factors and risk factors for lung metastasis in this single center provided insight about osteosarcoma management.
Spatial behavior of red deer (cervus elaphus) in northern apennines: are we managing them correctly?
Authors: Fontana Riccardo , Calabrese Licia , Lanzi Ambrogio , Armaroli Elisa , Pelliccioni Elisabetta Raganella 
Published: November 2021

Abstract
Backgound

Throughout its range, red deer is a well-studied species. In Italy the species occupies two ecologically different ranges: the Alps and the Apennine. Although several studies have described spatial behaviour of red deer in the Italian Alps, no data are available for the Apennine population.

Results

Spatial behaviour of 13 deer from Northern Apennine range was analysed for the first-time using GPS-GSM telemetry, from 2011 to 2017. Red deer displayed two different strategies coexisting in the population, i.e., migratory and stationary. Females tend to migrate more than males. We found a high level of inter individual variability in the date of migration/return, while each migratory deer is very conservative during the study period. Migration ranges are on average 12±4.2 km far apart from the resident range. Both migratory and resident deer displayed high site fidelity. No switch from migratory to stationary strategy was observed for any deer during the study period, which however could have been too short to detect any switch. At management level, a spatial mismatch was found between deer range and management units (districts) in 44.4% of the cases. Merging the districts belonging of each province to obtain an area of approximately 1.000 km 2 would partially solve such spatial mismatch reducing it to 22%.

Conclusions

Despite the low sample size, these results can provide guidance for future management actions. An in-dept study with a higher sample size is however required to better understand and manage the red deer Apennine population.
Capacitated Multi-objective Disassembly Scheduling with Fuzzy Processing Time viaAFruit Fly Optimization Algorithm
Authors: Yuan Gang , Yang Yinsheng , Tian Guangdong , Fathollahi-Fard Amir Mohammad 
Published: November 2021

Abstract
This work proposes a capacitated fuzzy disassembly scheduling model with cycle time and environmental cost, which has broad applications in remanufacturing and many other production systems. Disassembly scheduling is not always given accurately as a time quota in a production system, particularly in the obsolete products remanufacturing process. It is meaningful to study a novel model and algorithm based on uncertainty processing time to solve uncertainty disassembly scheduling problems. Therefore, a mixed-integer mathematical programming model is proposed to minimize the cycle time and environmental cost, whilst a metaheuristic approach based on a fruit fly optimization algorithm is developed to find a fuzzy disassembly scheduling scheme. To estimate the effectiveness of the proposed method, the proposed algorithm is tested with different size cases of products disassembly scheduling. Furthermore, experiments are conducted to compare with other multi-objective optimization algorithms. The computational results demonstrate the proposed algorithm outperforms other algorithms on computational efficiency and applicability performance. Finally, a case study is described to illustrate the proposed method. The main finding of this current work is to provide a new idea to solve the problem of disassembly scheduling in an uncertain environmental practically and efficiently.