bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histologic Characteristics of Invasive Oral Carcinoma and the Role of Epithelial-Mesenchymal Transition in Cancer Progression
Authors: Jetley Sujata , Sultan Beenish , Rana Safia , Khetrapal Shaan , Sharma Arun Prakash , Naseeruddin Khaja , Jairajpuri Zeeba S. 
Published: December 2021

Background:
To find the association of tumor budding, depth of invasion (DOI), and epithelial-to-mesenchymal transition (EMT) markers (E-cadherin and smooth muscle actin [SMA] expression) with prognostic factors of oral squamous cell carcinoma (OSCC).

Materials and Methods:
A cross-sectional study conducted on 50 cases of histologically proven OSCC were selected for the assessment of TNM staging, tumor budding, DOI, and EMT markers (E-cadherin and SMA expression). Associations were evaluated between established clinical prognostic factors and histological parameters. Statistical analysis was performed using SPSS version 21.0. (IBM, Chicago, Illinois, USA) and P < 0.05 was considered statistically significant.

Results:
In the study, the median age of distribution was 48.5 years with 86% of males. Tobacco consumption was seen among 90% of patients. A significant association of pathological TNM staging with tumor budding and DOI (P < 0.05). There was a loss of E-cadherin expression with loss of tumor differentiation, progressive TNM stage, increasing DOI and more tumor budding (P < 0.05). On the contrary, α-SMA (% stained cells) expression showed an increase with increasing pathological T stage, N stage, tumor budding, and DOI (P < 0.0001). However, the tumor differentiation showed no significant association with SMA expression (P = 0.44).

Conclusion:
It can be concluded that EMT has a strong association with OSCC demonstrated by loss of E-cadherin and increased expression of α-SMA at the invasive front in higher grade carcinomas, in tumors with increased DOI, high-risk tumor budding, and increased pathological T and cases showing lymph node metastasis. Hence, SMA can be used in conjunction with loss of E-cadherin expression for determining the aggressive nature of OSCC and predicting the survival rates of the patients.
Incidence and risk factors associated with knee injuries among active-duty military personnel in Saudi Arabia
Authors: Albishri Saeed F. , Ahmad Raafat , Al Zahrani Eidan M. , Jebakumar Arulanantham Z. , Woodman Alexander 
Published: December 2021

Background:
The numbers of musculoskeletal injuries and related risk factors are high, especially in military representatives, since they perform constant physical activities. One of the most common injuries is the knee injury. Although there are many studies relating to knee injuries in the military personnel, none of them have been conducted to estimate the incidence of this injury in the Kingdom of Saudi Arabia.

Objectives:
This study aimed to explore the incidence of knee injuries and risk factors among the military personnel on active duty in Saudi Arabia.

Materials and Methods:
This study included n = 2230 patients with knee injuries with a mean age 42.73 and standard deviation ± 16.343 from military branches of the Kingdom of Saudi Arabia (KSA) between 2010 and 2016. Data were collected from Saudi military hospitals and statistically analyzed using descriptive statistics and regression models. During the study, no injuries aggravations of existing injuries or conditions were reported.

Results:
The frequency distribution showed that anterior cruciate ligament (ACL) injuries were the most common of knee injuries (45.2%) followed by meniscus injury (24.9%) and internal derangement (10.1%) with an incidence rate 4.57, 0.25, and 0.10 respectively. Chi-square test revealed that sports are the most significant factor relating to all knee injuries (30.5%), followed by twisting injuries at 25% (P = 000).

Conclusion:
Future studies are recommended to generate effective measures to reduce the influence of preventable risk factors, such as sports and related physical activities, that contribute to knee injuries.
The Influence Of Brand Image, Promotion, And Price On Shopee Customer Loyalty (Case Study On Shopee Customers In Karawaci)
Authors: WasesoSegoro  , Sandra Restu Aulia  
Published: December 2021

Along with the times, people's lifestyles are increasingly instantaneous because the majority of people have high mobility in their daily activities. So that people are often looking for something practical and instantaneous in meeting their daily needs. Customer loyalty to voluntarily and continuously subscribe to certain companies for a long period of time. This study analyzes brand image , promotion, and price because these three factors play an important role in Shopee customer loyalty. The analytical tools used in this research are validity test, reliability test, normality test, multicollinearity test, heteroscedasticity test, multiple linear regression test, T test (partial), F test (simultaneous) and determination coefficient test using SPSS version 2.0 for windows. . The data used are primary data, the respondents in this study were 100 respondents, the sampling technique used was accidental sampling technique .The results showed that partially brand image, promotion, and price have a significant effect on customer loyalty. And simultaneously brand image, promotion, and price have a significant effect on Shopee customer loyalty.
Marketer as a Barbie Game Changer
Authors: Widyani Donafeby , Joseph Chen  
Published: December 2021

This paper addresses issues about how the Barbie doll can provide an unrealistic vision of how women should look and what marketers can do about it. Barbie is a well-known doll that has become a role model for girls. However, Barbie dolls have attracted much criticism. Studies found that Barbie shapes the body image of young girls and possibly creates body dissatisfaction and low self-esteem among girls. Body dissatisfaction can lead to eating disorders and low self-esteem can lead to depressive behavior. Answering that phenomenon, Barbie launched Barbie Fashionista that has a diverse body type. However, Girls still tend to choose thinner Barbie. Barbie’s marketer should encourage girls to play more with a more realistic body image Barbie such as curvy, tall, and petite, and encourage the children to feel good about their bodies.
MANHAJ IMAM AL-DARUQUTNI DALAM KITAB SUNAN-NYA
Authors: Muhammad Yunan  
Published: December 2021

Al-Daruqutni adalah seorang pemuda yang menghabiskan usianya untuk belajar hadis di daerahnya, serta mengadakan perlawatan ilmu ke berbagai kota pusat pengkajian hadis. Usahanya akhirnya menghasilkan sejumlah hasil karya. Sampai usia 80 tahun, ia persembahkan hidupnya untuk agama dan mendapat gelar amir al-mu’minin fi al-hadis. Salah satu karya monumentalnya adalah kitab Sunan al-Daruqutni, yang menjadi perhatian sarjanawan pemerhati hadis. Dalam tulisan ini, penulis akan mengulas bagaimana manhaj Imam al-Daruqutni dalam kitab sunan-nya. Tujuannya untuk memperkenalkan manhaj yang digunakan oleh al-Daruqutni dalam menyusun kitab hadis. Tulisan ini menggunakan metode library research dengan pendekatan historis untuk menelaah biografi dan manhaj yang digunakan al-Daruqutni.
NÜFUS YAŞLANMASININ EKONOMİK BÜYÜME ÜZERİNDEKİ ETKİLERİ: OECD ÜLKELERİ ÖRNEĞİ
Authors: KARAGÖZ Hüseyin 
Published: December 2021

Amaç: Dünyada doğum oranları azalırken, yaşam süreleri uzamakta ve toplumdaki yaşlı nüfusun oranı hızla artmaktadır. Yapılan nüfus projeksiyonları, günümüzde genç nüfusa sahip olan birçok ülkenin yakın gelecekte nüfusu yaşlı ülkeler arasında yer alacağını göstermektedir. Bu durum, yakın geçmişe kadar gelişmiş ülkelere özgü bir sorun olarak kabul edilen yaşlanma olgusunun günümüzde gelişmekte olan ülkeler açısından da önemli bir sorun haline geldiğine işaret etmektedir. Yaşlanma olgusu ülke ekonomileri üzerinde doğrudan ve dolaylı etkiler yaratırken, bu etkilerin hangi yönde gerçekleştiği konusunda görüş birliği sağlanamamaktadır. Bu çalışmada, nüfus yaşlanmasının ekonomik büyüme üzerindeki etkilerinin araştırılması amaçlanmaktadır.
Yöntem: Araştırmada kullanılan veriler Birleşmiş Milletler, Dünya Bankası ve OECD veri tabanından elde edilmiş ve analiz yöntemi olarak panel veri analizi modeli tercih edilmiştir. Çalışma, OECD ülkelerinin 1995-2017 dönemini kapsamaktadır.
Bulgular: Elde edilen bulgulara göre, yaşlı bağımlılık oranı ve ortalama eğitim yılında meydana gelen artışlar ekonomik büyümeyi olumsuz yönde etkilerken, ulusal tasarruf ve sosyal harcamalarda yaşanan artışlar ekonomik büyümeyi olumlu yönde etkilemektedir.
Özgünlük: Nüfus ve ekonomik büyüme arasındaki ilişkiyi inceleyen çeşitli çalışmalar bulunmaktadır. Bununla birlikte, nüfusun yaş yapısındaki değişimin ekonomik etkilerini inceleyen çalışmalar nispeten daha sınırlı düzeyde kalmaktadır. Bu çalışmada, yaşlanan nüfusun ekonomik etkileri incelenmekte ve nüfusun yaşlanma göstergelerinin yanı sıra sosyal harcamalar, ulusal tasarruflar ve ortalama eğitim süreleri gibi yaşlanma olgusuyla ilişkili olan kavramlara da yer verilmektedir.
The Influence of Organizational Commitment, Competence of Village Fund Management Offficers, and Utilization of Information Technology on Accountability of Village
Authors: Apriana Siska , Said Darwis , Nurleni Nurleni 
Published: December 2021

<em>This study aims to analyze the effect of commitment of organization, competence of village fund management officers, and utilization of information technology on accaountability of village financial management</em><em> either partially or simultaneously.The data used in the study are primary data in the form of questionnaires with a total sample of 96 respondents. The method used is a quantitative approach and multiple linear regression analysis which determined by purposive sampling method. The findings from this research indicate that (1) partially commitment of organization, competence of village fund management officers and utilization of information technology has a positive effect and significant impact on the accountability of village financial management (2) commitment of organization, competence of village fund management officers and utilization of information technology has simultaneous effect on the accountability of village financial management.</em>
CAN TRADITIONAL RETAILERS USE STRATEGY TO FIGHT AGAINST MODERN ATTACKS?
Authors: Triono Rachmadi Agus , Dalimunthe Zuliani , Arif Helman 
Published: December 2021

<p>Despite rapid growth in online type, the majority Indonesian retail market is offline shopping because of households disperse across thousand cities and islands. However, the threat comes from corporatized modern retailers. Typically, attacks from modern retailers in the form of franchised minimarkets endangered the existence of traditional retailers which generally are small sized and independently owned by individual or household. This research investigates how traditional retailers can deliver a strategic response to the presence of modern retailers, and to examine whether there are differences in performance among business entities that use different strategic responses. We also investigate if there are differences, which strategic response would give the best result in performance. Questionnaires were distributed to 109 respondents using convenience sampling. An ANOVA was done at respective types of retailers' buyers. There is no significant evidence that the strategic response developed by traditional retailers differed from one another. Furthermore, we found that the performance of traditional retailers are below modern retailers, except for those that belong to a higher tier of performance. Higher tier traditional retailers are the best strategic group in traditional retailers and their performance statistically could equate to the performance of modern retail.</p><p> </p><p><strong><em>Keywords</em></strong>: Indonesian retail market, small-scale retailer strategy, strategic group, strategic response</p>
Protestants d’Auvergne
Authors: Audisio Gabriel 
Published: December 2021

L’Auvergne passe pour avoir été un bastion catholique, peu sensible à la Réforme. Pourtant les idées luthériennes s’y implantèrent dès les années 1530 et le protestantisme y est encore présent à la veille de la Révolution. L’auteur tente une approche à partir des personnes et non des institutions dans les quatre départements (Allier, Cantal, Haute-Loire, Puy-de-Dôme) et autour des quatre lieux de culte autorisés (Maringues, Job, Parentignat, La Gazelle). Le fichier de quelque 1 500 personnes révèle une communauté peu nombreuse, dispersée, indigente, fortement rurale. La persécution, avant l’édit de Nantes (1598) et après sa révocation (1685), a entraîné à la fois une notable érosion, une forte émigration mais aussi une tenace résistance sur place.
Promising implications of Tinospora cordifolia utilization and its functional significance: A review
Authors: Khan Khursheed Alam , Katiyar Shiv Kumar , Nema Prabhat K 
Published: December 2021

Tinospora cordifolia (TC) a traditional plant used in Indian Ayurvedic medicine widely. Different parts of this plant such as stem, roots, leaves are used for treatment and control of various health issues as well as an ingredient in functional foods. It possesses many health promoting and protecting properties. The present article is a critical review providing a comprehensive discussion on therapeutic application and functional significance of TC. The aim of this review is to develop a clear understanding of these issues. Specifically coverage in this review are published information in the areas of Diabetic retinopathy, Free radical scavenging, Anti-Diabetic, Cognition enhancing, Anti-inflammatory, Anti-allergic, Immunomodulatory and Anti-cancer, Management of Hay Fever, Antioxidant, Hypoglycaemic and Hypolipidaemic, Osteoblasts formation, Immunomodulatory, Immunostimulatory, Protection from Skeletal Muscle Atrophy, Gastroprotective, Antiosteoporotic etc. Uses of TC as plant digestive enzyme and as supplementation in formulation of various functional foods are also compiled for the information and knowledge of food scientists and technologists. The future scope of the review remains in exploiting TC so as to enable new and effective formulation in disease eradication. Further studies are necessary, however, to investigate the best practices for the promising implications of TC utilization and its functional significance.
Case report: a rare cause of proptosis
Authors: Vimalachandran D , Baraka ME 
Published: December 2021

Proptosis is the forward protrusion of the eye from its normal position in the orbit. There are many causes, the commonest of both unilateral and bilateral proptosis being thyrotoxicosis. Antral tumours are an uncommon cause of proptosis but one that should be considered in any patient with proptosis. A mucocele is a cystic expansile lesion that is lined with epithelium and filled with mucoid secretions. It results from disrupted or obstructed drainage of the paranasal sinuses. Maxillary sinus mucoceles are infrequent and can result in proptosis, nasal obstruction, facial swelling and involvement of the oral cavity.
Primary lymphomas of the sinonasal tract are rare, representing approximately 8% of sinonasal malignancies, the maxillary sinus being the commonest site. Malignancy is a diagnosis that must be considered in the aetiology of maxillary mucocele and we believe that this is the first documented case of bilateral maxillary mucocele caused by non-Hodgkin's lymphoma.
ANALISIS PELAYANAN ADMINISTRASI DAN TANGGUNG JAWAB PETUGAS TIKET KAPAL JASA TRANSPORTASI LAUT TERHADAP KEPUASAN PENUMPANG PADA PT. PELAYARAN NASIONAL INDONESIA CABANG SURABAYA
Authors: Widyawati Nur , Zulviana Ira 
Published: December 2021

Penelitian ini bertujuan untuk mengetahui pengaruh pelayanan administrasi dan tanggung jawab terhadap kepuasan penumpang. Penelitian ini merupakan penelitial kuantitatif. Populasi yang digunakan adalah seluruh penumpang yang menggunakan jasa transportasi laut pada PT. Pelayaran Nasional Indonesia dengan jumlah sampel yang digunakan sebagai penelitian sebanyak 56 penumpang, untuk menganalisis data digunakan teknik analisis regresi linier berganda. Hasil perhitungan menggunakan analisis regresi linier berganda. Pada uji t, diperoleh nilai koefisiensi regresi untuk masing-masing variabel bebas adalah -,005 untuk pelayanan administrasi (X1) dan 0,399 untuk tanggung jawab (X2) nilai koefisiensi regresi yang positif menunjukkan bahwa hubungan dari masing-masing variabel bebas adalah positif. Hasil uji t pada variabel pelayanan administrasi menunjukkan thitung sebesar -0,34 lebih kecil ttabel sebesar 0,401 (α sebesar 0,973 > 0,005) sehingga secara parsial pelayanan administrasi sebagai variabel bebas X1 tidak berpengaruh terhadap kepuasan penumpang sedangkan tanggung jawab sebagai variabel bebas X2 memberikan pengaruh positif terhadap kepuasan penumpang yaitu dengan dengan thitung 3,105 lebih besar dari ttabel 2,005 (α sebesar 0,003 < 0,05). Uji ANOVA pelayanan administrasi (X1), tanggung jawab (X2) berpengaruh signifikan secara simultan terhadap kepuasan penumpang (Y) dengan nilai α sebesar 0,010 < 0,05.
Khảo sát hấp phụ As(V) trong dung dịch nước bằng vật liệu zeolite biến tính bằng Mn
Authors: Bùi Văn Thắng , Trần Thị Xuân Mai 
Published: December 2021

Zeolite và zeolite biến tính bằng Mn (Mn/Zeolite) được sử dụng làm vật liệu để hấp phụ As(V) trong nước. Vật liệu Mn/Zeolite có khả năng hấp phụ As(V) tốt hơn zeolite chưa biến tính và ít chịu ảnh hưởng bởi pH của dung dịch. Động học hấp phụ As(V) trên vật liệu tuân theo mô hình động học biểu kiến bậc 2 với hệ số tương quan cao (R2 > 0,99). Dung lượng hấp phụ cực đại As(V) tính theo phương trình Langmuir trên Z-1.2 và MZ-2.5 là 7,96 và 18,64 mg/g.
Khảo sát ảnh hưởng của nồng độ carboxymethyl cellulose đến khả năng sinh trưởng, tồn tại và kháng nấm của vi khuẩn Lactobacillus trên chủng nấm mốc Lasiodiplodia pseudotheobromae
Authors: Nguyễn Thị Ngọc Trúc , Đỗ Thị Hiền , Nguyễn Phan Thảo 
Published: December 2021

CMC (Carboxymethyl cellulose) được sử dụng tạo màng bao gói để bảo quản trái cây, nhằm giữ được độ tươi mà không ảnh hưởng đến chất lượng của thực phẩm. Các chủng vi khuẩn Lactobacillus spp.đặc biệt là L.plantarum CC6, L.fermentum DC2 và L.fermentum DG2 được chứng minh có hoạt tính kháng nấm cao. Nghiên cứu đã sử dụng kết hợp CMC và ba chủng vi khuẩn Lactobacillus spp. nhằm tăng hoạt tính kháng nấm Lasiodiplodia pseudotheobromae gây bệnh trên trái cây đặc biệt chôm chôm sau thu hoạch để kéo dài thời gian bảo quản. Kết quả khảo sát cho thấy các chủng vi khuẩn Lactobacillus spp. ở 13oC phát triển tốt hơn nhiệt độ phòng. Kết hợp với 1% CMC ở nhiệt độ phòngvà 1,5% CMC ở 13oC vi khuẩn L.fermentum DC2 và L.plantarum CC6 có khả năng phát triển và kháng nấm bệnh tốt nhất.
Khảo sát ảnh hưởng của vi khuẩn nội sinh cây lúa đến sinh trưởng của một số giống lúa trồng phổ biến vùng Đồng bằng sông Cửu Long ở giai đoạn mạ
Authors: Nguyễn Thị Pha , Trần Văn Bé Năm , Trần Đình Giỏi 
Published: December 2021

Sản xuất lúa ở Đồng bằng sông Cửu Long chủ yếu sử dụng phân bón hóa học làm tăng giá thành sản phẩm và ảnh hưởng xấu đến độ phì của đất. Nghiên cứu đã được thực hiện nhằm đánh giá sự ảnh hưởng của 04 dòng vi khuẩn nội sinh NS01, NS08, NS17 và NS25 có khả năng tổng hợp NH4+ và hòa tan lân trong dịch nuôi đến sinh trưởng của các giống lúa IR50404, OM4900 và OM5451 ở giai đoạn mạ. Kết quả cho thấy giống lúa IR50404 chủng với dòng vi khuẩn NS25 cho kết quả tốt nhất ở các chỉ tiêu theo dõi bao gồm hàm lượng diệp lục tố, chiều cao cây, chiều dài rễ, số rễ và khối lượng chất khô. Giải trình tự vùng gen 16S rDNA, xác định được dòng NS25 thuộc chi Bacillus.
The Implementation of Grammatical Error Analysis to Improve Students’ Writing Skill on Recount Text for Students Class X MIA At SMA Tri Dharma Kosgoro Dompu
Authors: Arnillah Nadiya 
Published: December 2021

This study is a classroom action research that focuses on the implementation of grammatical error analysis to improve students’ writing skill on recount text for students. The study conducted at SMA Tri Dharma Kosgoro Class X MIA that consisted of 25 students; 15 male and 10 female. Apart from implementing the grammar error analysis to enhance students’ writing skill, the researcher also identify some errors of students’ writing particularly on grammatical error and analyze some factors of these errors. The implementation of this research was in cycle I that consist of eight meetings. Study shows that the implementation of grammatical error analysis can enhance the students’ understanding in writing recount text. This has been shown by the improvement of student’s score. Moreover, the kinds of the students’ grammatical errors could be classified into seven categories namely errors in verb groups, errors in subject and verb agreement, errors in article, errors in pluralization, errors in conjunction, errors in preposition, and errors in pronoun. The identification of these type of grammatical error is paramount due to these could help students understand some components of grammar that students should master to improve their understanding in writing recount text.
Comparison of IL-6 and TNF-Alfa Serum Levels in Pre and Post Radiotherapy Nasopharyngeal Carcinoma Patients at the NTB Provincial Hospital
Authors: Wina Annisa Alifia 
Published: December 2021

Nasopharyngeal carcinoma is often found in Asia, especially in South and Southeast China, with Indonesia being the fourth most common malignancy after breast cancer, cervical cancer, and lung cancer. NPC can generally be diagnosed only in the late stages, so it can increase morbidity and mortality. One of the recommendations for therapy for NPC is radiotherapy, but radiotherapy still fails due to a chronic inflammatory process involving several inflammatory cytokines such as IL-6 and TNF-Alfa. Cytokines play a role in various signaling pathways that can lead to increased proliferation, migration, invasion, angiogenesis, and inhibit apoptosis and even have an effect on resistance to therapy in many cancer cells, especially NPC. A good understanding of this pro-inflammatory cytokine, is expected to improve the prognosis in NPC patients in the future, knowing serum levels of IL-6 and TNF-Alfa pre and post radiotherapy. This is a preliminary study or literature study before the main study is conducted. Sources include scientific journals accessed through an online portal, namely NCBI. Poor prognosis in NPC patients with high serum levels of IL-6 and TNF-Alfa. The higher the levels of IL-6 and TNF-Alfa in post-radiotherapy NPC patients, the worse the condition is because these pro-inflammatory cytokines can activate various signaling pathways.