bluuebunny/crossref_metadata_2025_split huggingface dataset:
Status of development and planning activities on CANS in Korea
Authors: Lee Chang-Hee , Moon Myungkook , Lee Dong Won , Kim Han Sung , Kwon Hyeok-Jung , Lee Pilsoo , Kim Dong Soo , Seo Hyo Jung , Hong Bong Hwan , Lee Hee-Seock , Bakhtiari Mahdi 
Published: September 2021

This report reviews the overall status of the development and planning activities of compact accelerator-based neutron sources in Korea. For the last decade, the demand for the technology development and application of CANS has significantly increased, and becomes widely accepted by the science, engineering and industry sectors. Since the first technical workshop focused on CANS under the support of the Korea Nuclear Society in fall 2016, there have been numerous efforts to launch projects by several groups. Although unsuccessful, two CANS projects were newly launched in 2020. One is the 30-MeV cyclotron-based neutron source for industrial neutron imaging at the Korea Atomic Energy Research Institute (KAERI), and the other is the BNCT technology development at the Korea Institute of Radiological & Medical Sciences. A project proposal for an expansion of the proton LINAC facility at KAERI to 200 MeV for semiconductor irradiation testing through the produced neutron field is now almost complete and will be submitted to the government funding agency for review. The CANS project for BNCT based on the proton LINAC developed by the Dawonsys consortium is briefly described. The new neutron source based on electron LINAC is prepared by the Pohang Light Source laboratory, and the initial consideration and application targets are also described. A new strategic plan for national R&D on radiation technology and the enforcement of its infrastructure is still under way, and a more systematic approach to the development and application of neutron sources will be implemented through the strategic planning.
Relationship between 25-Hydroxy Vitamin D Levels and Type of Morbus Hansen
Authors: Theresia L. Toruan  , Mutia Devi  , Theodorus  , Rivai Allin Marlina 
Published: September 2021

Background: Morbus Hansen is a chronic granulomatous infection of Mycobacterium leprae (M. leprae) which is characterized by cardinal signs in the form of numbness of the skin, thickening of peripheral nerves and acid-fast bacteria (AFB) were found on bacterioscopic examination. WHO has classified MH into paucibasilar MH (MH-PB) and multibasilar MH (MH-MB) based on the number of skin lesions or bacterial index (IB). Vitamin D in MH is known to act as an immunomodulator. This study aims to determine the relationship between serum 25(OH)D levels with Morbus Hansen type at RSUP Dr. Mohammad Hoesin and Leprosy Hospital Dr. Rivai Abdullah Palembang.
Methods: A laboratory observational study with a case series design was undertaken at the Dermatology and Venereology (DV) Polyclinic of Infectious Dermatology (DI) Mohammad Hoesin Hospital Palembang since December 2019 to January 2020. A sample of 33 patient MH met the inclusion criteria, consisting of 22 patients with Morbus Hansen (MH) type MB and 11 patients with Morbus Hansen (MH) type PB. Comparison of serum 25(OH)D levels between MB and PB type MH patients was analyzed using the Independent T Test, the relationship between serum 25(OH)D levels and MH type was analyzed using the Fisher Exact Test and the correlation between serum 25(OH)D levels with type of MH was analyzed using Spearman Rho's test. Data analysis using SPSS version 22.0.
Results: In this study, there were no differences in demographic characteristics of gender, age, age category, body mass index, education and occupation between MB and PB type MH patients (p > 0.05). There were no difference in duration of therapy (p = 0.155), ENL reaction (p = 0.276) and patient status (p = 0.304) between MB and PB type MH patients, but there were differences in bacterial index (p = 0.000) and clinical spectrum (p = 0.000) between MB and PB type MH patients. There is a difference in the mean level of 25(OH)D between MB and PB type MH patients (p = 0.006), there is a significant relationship between 25 (OH)D levels and MH type patients, (OR = 9.643 ; p = 0.010) and there is a significant moderate positive correlation between levels of 25 (OH)D and the type of MH (r = 0.467; p = 0.006).
Conclusion: It can be concluded that there are differences in serum 25(OH)D levels among Morbus Hansen type. In addition, there is a significant relationship between serum 25(OH)D levels with Morbus Hansen type.
Manajemen Rekrutmen Santri Tahfidz Al-Qu’ran di Ma'had Tahfidz Bina Madani Putri Bogor
Authors: Qorni Agung Wais Al , Mujahidin Endin 
Published: September 2021

<p class="15bIsiAbstractBInggris">The achievement in implementing all programs in the tahfidz al qur'an institution is the result of a combination of neat management, the cleverness of the educators and the availability of facilities and infrastructure as well as the input of quality students, this research finds out how the management of santri Mahad Tahfidz bogor recruitment, a place in meticulous is Ma'had Tahfidz Al-Qur'an Boarding Scool which has a focus and commitment in fostering its students to complete memorization of 30 juz, Ma'had bina Madani Boarding scool which is equivalent to the level of Madrasah aliyah. Research shows the existence of santri recruitment management which is carried out in ma'had bina madani for adequate input attainment in achieving the target of memorizing the Qur'an. This study uses a descriptive qualitative approach with data collection methods with in-depth interviews, observation and documentation. The results showed that ma'had bina madani had managed the recruitment of students which included (1) Planning for Santri Tahfidz (2) Implementation of the New Santri Tahfidz Recruitment which included one PSB committee formation, two determinations of the number of students received, three announcements of new santri admissions. Four Registration Five Entrance Selection Six Announcement of New Santri Admission (3) PSB Evaluation (4) New Student Orientation. </p><p class="16aJudulAbstrak"><strong>Abstrak </strong> </p><p class="16bIsiAbstrak">Ketercapaian dalam melaksanakan semua program dalam lembaga tahfidz al qur'an merupakan hasil dari paduan antara menajemen yang rapih, keiklasan para pendidik dan ktersediaan sarana dan prasarana juga input peserta didik yang berkualitas, peneletian ini mengetahui bagaimana manajemen rekrutmen santri Mahad Tahfidz bogor, tempat yang di teliti merupakan Ma'had Tahfidz Al-Qur'an Boarding Scool yang memiliki fokus dan komitmen dalam membina peserta didik nya untuk menyelesaikan hafalan 30 juz, Ma'had bina Madani Boarding scool yang setara dengan jenjang Madrasah aliyah. Penelitian menunjukan adanya manajemen rekrutmen santri yang dilaksankan di ma'had bina madani untuk Ketecapaian Input yang memadai dalam mencapai target hafalan al quran. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan metode pengumpulan data dengan wawancara mendalam, observasi dan dokumentasi. Hasil penelitian menunjukan bahwa ma'had bina madani telah melakukan manjemen rekrutmen santri yang meliputi (1) Perencanaan Santri Tahfidz (2) Pelaksanaan Rekrutmen Santri Tahfidz Baru yang Mencakup satu Pembetukan panitia PSB, Dua Penetuan Jumlah Santri yang di terima, tiga Pengumuman Penerimana santri Baru Empat Pendaftaran Lima Seleksi Masuk Enam Pengumuman Penerimaan Santri Baru (3)Evaluasi PSB (4) Orientasi Peserta didik Baru. </p>
Involvement of the Interferon Tau Gene in Maternal Recognition of Gestation in Sheep
Authors: Conde-Hinojosa Miguel Paul , Gallegos-Sánchez Jaime , Torres-Hernández Glafiro , Salazar-Ortiz Juan , Clemente-Sánchez Fernando , Cortez-Romero César 
Published: September 2021

Objective: To describe the involvement of the interferon tau gene in the maternal recognition of pregnancy in sheep.
Design/Methodology/Approach: A search and analysis of the scientific documents retrieved from the Web of Science and Scopus databases related to the functions of the interferon tau gene in the maternal recognition of pregnancy in sheep were conducted.
Results: The interferon tau gene (IFNτ) participates in maternal recognition of pregnancy to avoid possible rejection of the embryo, and supports the secretion of progesterone involved in preparing the endometrium for implantation; it also inhibits myometrial motility to maintain pregnancy. IFNτ stimulates the transcription of so-called interferon-stimulated genes (ISGs), which are the effectors of cell-autonomous antiviral defense. One of the representative members of ISGs is the interferon 15-stimulated gene (ISG15) which regulates endometrial receptivity at implantation, as well as survival, growth and development of the conceptus.
Study Limitations/Implications: Most embryonic losses occur between fertilization and maternal recognition of pregnancy. Understanding this issue is essential to understanding the possible causes of early pregnancy losses.
Findings/Conclusions: Considerable progress has been made in the discovery of how the IFNτ and ISG15 genes act in maternal recognition of gestation in sheep
THE TOOLS OF “HYBRID WARS”: LAWFARE
Authors: Лобода Ю. 
Published: September 2021

У статті «Засоби «гібридних воєн»: правовійна» на основі огляду сучасної західної літератури проаналізовано таку форму репрезентації відсутності нейтральності права як «правовійна».
У розділі «Визначення головної проблеми» зазначено, що важливим компонентом сучасних «гібридних воєн» є зловживання правовими нормами; міра цих зловживань та способи їх подолання досі залишаються невизначеними. У розділі «Аналіз останніх публікацій» вказано на теоретичні роботи західних дослідників з питань правовійни, а також на кейс, де розглядається проблема правового регулювання військової тактики. Головна мета статті – проаналізувати основні аспекти появи правовійни, його визначення та складність в умовах сучасних гібридних воєн з не-правової точки зору.
У розділі «Виклад основного матеріалу» було розглянуто, які складності пов’язані з дотриманням Женевської конвенції, яка визначає статус комбатантів та некомбатантів, в контексті кейсу Маркуса Латтрелла, який описав свій досвід участі в операції «Червоні крила» на сході Афганістану влітку 2005 року, де автор говорить про те, як на полі бою відбувається «маніпуляція правовими нормами на користь ворога». Сучасні дослідники зазначають, що правовійна може бути атрибутом не тільки тактичного рівня збройного конфлікту, але й стратегічного, перетворившись на потужний інструмент сучасних «гібридних воєн». Головна складність, яка характеризує цю проблему – принципова неможливість вирішити її в рамках теорії права. Російсько-українська війна знову акцентувала проблему, яка була завжди актуальною для сучасних західних країн – як вирішити протиріччя між нагальними вимогами військової тактики та міжнародним правом?
У висновках зазначається складність і важливість дослідження проблеми правовійни, а також причини відсутності її вирішення.
СОЦІАЛЬНО-ПОЛІТИЧНИЙ КОНТЕКСТ ВІЙНИ НА СХОДІ УКРАЇНИ ТА ОСНОВНІ НАПРЯМИ ПРОТИДІЇ ГІБРИДНІЙ АГРЕСІЇ
Authors: Осьодло В. , Будагьянц Л. 
Published: September 2021

У статті розкрито теоретичні засади фундаментальних смислів боротьби української політичної нації на ствердження власної історичної суб’єктності на тлі глобалізації, що зумовлюють особливості становища нових демократій під час миру та під час війни.
Проаналізовано соціально-політичний контекст війни на Сході України який на думку авторів доцільно розглядати через призму національного буття української політичної нації та національної держави як інституту загальної волі нації. Розкрито сутність «нової війни» в умовах військової агресії РФ проти України, що відображає безпрецедентну постбіполярну дійсність, пов’язану з сучасною політикою ідентичності. Доведено, що одним із успішних шляхів захисту є створення мережевої безпеки, що ґрунтується на співпраці всіх громадян щодо захисту власних суспільств, держав і міжнародної безпекової мережі.
Представлено, що ключовим ціннісним пріоритетом, який спроможний витримувати негативні впливи й швидко відновлюватися та визначений центральним у концепціях усталеного розвитку ООН, ЄС і НАТО, є «стійкість».
HEALTH ECONOMICS IN THE FIELD OF PROSTHETICS AND ORTHOTICS: A GLOBAL PERSPECTIVE
Authors: Kannenberg Andreas , Seidinger Susanne 
Published: September 2021

The rapid advancement of prosthetic and orthotic (P&O) technology raises the question how the industry can ensure that patients have access to the benefits and providers get paid properly and fairly by healthcare payers. This is a challenge that not only P&O but all areas of health technology face. In many areas of medicine and health products, such as drugs and medical devices, health-technology assessments (HTA) have become a standard procedure in the coverage and reimbursement process. In most countries, P&O is lagging behind that development, although some countries have already formalized HTA for prosthetic and orthotic products and may even use cost-effectiveness analyses to determine pricing and payment amounts. This article gives an overview on the coverage and reimbursement processes in the United States, Canada, Germany, France, Sweden, the United Kingdom, Poland, Japan, and China. This selection reflects the variety and diversity of coverage and reimbursement processes that the P&O industry faces globally. The paper continues with an overview on the necessary research and investment efforts that manufacturers will have to make in the future, and contemplates the likely consequences for the manufacturer community in the market place. Health economics may help support the transition from price-based to value-based coverage and reimbursement but will come at considerable costs to the industry.
Article PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/35298/28317
How To Cite: Kannenberg A, Seidinger S. Health economics in the field of prosthetics and orthotics: A global perspective. Canadian Prosthetics & Orthotics Journal. 2021; Volume 4, Issue 2, No.6. https://doi.org/10.33137/cpoj.v4i2.35298
Corresponding Author: Andreas Kannenberg, MD (GER), PhDExecutive Medical Director North America, Otto Bock Healthcare LP, 11501 Alterra Parkway, Suite 600, Austin, Texas, USA.E-Mail: andreas.kannenberg@ottobock.comORCID ID: https://orcid.org/0000-0001-7983-1744
ACADEMIA’S ROLE TO DRIVE CHANGE IN THE ORTHOTICS AND PROSTHETICS PROFESSION
Authors: Kogler Géza , Hovorka Christopher 
Published: September 2021

This position paper outlines the important role of academia in shaping the orthotics and prosthetics (O&P) profession and preparing for its future. In the United States, most healthcare professions including O&P are under intense pressure to provide cost effective treatments and quantifiable health outcomes. Pivotal changes are needed in the way O&P services are provided to remain competitive. This will require the integration of new technologies and data driven processes that have the potential to streamline workflows, reduce errors and inform new methods of clinical care and device manufacturing. Academia can lead this change, starting with a restructuring in academic program curricula that will enable the next generation of professionals to cope with multiple demands such as the provision of services for an increasing number of patients by a relatively small workforce of certified practitioners delivering these services at a reduced cost, with the expectation of significant, meaningful, and measurable value. Key curricular changes will require replacing traditional labor-intensive and inefficient fabrication methods with the integration of newer technologies (i.e., digital shape capture, digital modeling/rectification and additive manufacturing). Improving manufacturing efficiencies will allow greater curricular emphasis on clinical training and education – an area that has traditionally been underemphasized. Providing more curricular emphasis on holistic patient care approaches that utilize systematic and evidence-based methods in patient assessment, treatment planning, dosage of O&P technology use, and measurement of patient outcomes is imminent. Strengthening O&P professionals’ clinical decision-making skills and decreasing labor-intensive technical fabrication aspects of the curriculum will be critical in moving toward a digital and technology-centric practice model that will enable future practitioners to adapt and survive.
Article PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/36673/28349
How To Cite: Kogler GF, Hovorka CF. Academia’s role to drive change in the orthotics and prosthetics profession. Canadian Prosthetics & Orthotics Journal. 2021; Volume 4, Issue 2, No.21. https://doi.org/10.33137/cpoj.v4i2.36673
Corresponding Author: Géza F. KoglerOrthotics and Prosthetics Unit, Kennesaw State University.E-Mail: gkogler1@kennesaw.eduORCID ID: https://orcid.org/0000-0003-0212-5520
SABOLICH PROSTHETICS AND RESEARCH: A CONTINUING JOURNEY ON THE ROAD LESS TRAVELED
Authors: Sabolich Scott 
Published: September 2021

The Sabolich family had made a unique contribution to both the clinical practice of Prosthetics and Orthotics as well as the business of prosthetics and orthotics. In preparing for this Special Edition, as Co-Editor-in-Chief, I felt it important to include the story of the Sabolich vision for prosthetic clinical practice and their experiences in achieving that vision. Their story is an important part of the history of prosthetic clinical practice in the United States. Their rethinking of what a clinical practice could look like and function as was far-sighted. Achieving it required both risk taking, as well as a new business model. The reaction from other Prosthetic and Orthotic practitioners was strong. Some saw the new model as visionary while others found it provocative. The model was based on a concierge style practice, which provided a premium service to a patient from first appointment to providing and maintaining of their device. They then went further than that by incorporating in-house research into their facility to develop new and innovative prosthetic approaches that would make them leaders in the field of socket design and fit. Their vision was to be a Center of Excellence for Prosthetics and Orthotics Practices, a vison that many people within the sector would likely agree was achieved. I invited current CEO of Scott Sabolich Prosthetics and Research to reflect back on the history of his family’s business and how multiple generations of his family were able to see gaps and create opportunities where others could not see beyond the status quo and even fought hard to maintain the status quo. The evolution of this company provides insight into the successful development of novel business practices and economics in Prosthetics and Orthotics, while staying true to core service principles. The result was a business model that, in hind sight, had future-proofed the company in the face of the global economic challenges that impacted the sector in 2008-9 and beyond. It is also an indicator of what opportunities there are, at the business, clinical and technical levels, for those who take the risk of breaking from the status quo. Because of time and capacity constraints on the part of Mr. Scott Sabolich, it was agreed that his professional opinions and insights would be done in an interview format.
Article PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/37089/28362
How To Cite: Sabolich S. Sabolich Prosthetics and Research: A continuing journey on the road less traveled. Canadian Prosthetics & Orthotics Journal. 2021;Volume 4, Issue 2, No.14. https://doi.org/10.33137/cpoj.v4i2.37089
Corresponding Author: Scott Sabolich, Scott Sabolich Prosthetics and Research, Oklahoma City, USA.E-Mail: scott.sabolich@scottsabolich.comORCID ID: https://orcid.org/0000-0001-5723-7963
PENILAIAN KINERJA KARYAWAN MENGGUNAKAN METODE TOPSIS
Authors: Sukamto Sukamto , Andriyani Yanti , Wahyuni Kiki 
Published: September 2021

Abstract: The Employee’s performance appraisal is something that must be done by the company or organization to be able to evaluate the company's development. Permata Hati Duri Hospital conducts employee performance appraisals every month. This study aims to create an employee performance appraisal system that can facilitate the hospital when evaluating employee performance. The assessment criteria used are competence, professionalism, communication, management and friendliness with. This research uses TOPSIS method, PHP and MySQL programming as database. The sample used is 10 employees. The final result obtained in the system is the result of ranking employee. Keywords: employee performance appraisal; topsis. Abstrak: Penilaian kinerja karyawan adalah hal yang harus dilakukan oleh perusahaan atau organisasi untuk dapat mengevaluasi perkembangan perusahaan. Rumah Sakit Permata Hati Duri melakukan penilaian kinerja terhadap karyawan pada setiap bulannya. Penelitian ini bertujuan membuat sistem penilaian kinerja karyawan yang dapat memudahkan pihak rumah sakit saat melakukan penilaian kinerja karyawan. Kriteria penilaian yang digunakan adalah kompetensi, profesionalisme, komunikasi, manajemen dan keramahan dengan. Penelitian ini menggunakan metode TOPSIS, pemograman PHP dan MySQL sebagai database. Adapun sampel yang digunakan adalah 10 karyawan. Hasil akhir yang didapatkan pada sistem berupa hasil perangkingan nilai karyawan. Kata kunci: penilaian kinerja karyawan; topsis.
Metabolic Biomarkers for the Early Detection of Cancer Cachexia
Authors: O’Connell Thomas M. , Golzarri-Arroyo Lilian , Pin Fabrizio , Barreto Rafael , Dickinson Stephanie L. , Couch Marion E. , Bonetto Andrea 
Published: September 2021

Background:Cancer cachexia is a severe metabolic disorder characterized by progressive weight loss along with a dramatic loss in skeletal muscle and adipose tissue. Like cancer, cachexia progresses in stages starting with pre-cachexia to cachexia and finally to refractory cachexia. In the refractory stage, patients are no longer responsive to therapy and management of weight loss is no longer possible. It is therefore critical to detect cachexia as early as possible. In this study we applied a metabolomics approach to search for early biomarkers of cachexia.Methods:Multi-platform metabolomics analyses were applied to the murine Colon-26 (C26) model of cachexia. Tumor bearing mice (n= 5) were sacrificed every other day over the 14-day time course and control mice (n= 5) were sacrificed every fourth day starting at day 2. Linear regression modeling of the data yielded metabolic trajectories that were compared with the trajectories of body weight and skeletal muscle loss to look for early biomarkers of cachexia.Results:Weight loss in the tumor-bearing mice became significant at day 9 as did the loss of tibialis muscle. The loss of muscle in the gastrocnemius and quadriceps was significant at day 7. Reductions in amino acids were among the earliest metabolic biomarkers of cachexia. The earliest change was in methionine at day 4. Significant alterations in acylcarnitines and lipoproteins were also detected several days prior to weight loss.Conclusion:The results of this study demonstrate that metabolic alterations appear well in advance of observable weight loss. The earliest and most significant alterations were found in amino acids and lipoproteins. Validation of these results in other models of cachexia and in clinical studies will pave the way for a clinical diagnostic panel for the early detection of cachexia. Such a panel would provide a tremendous advance in cachectic patient management and in the design of clinical trials for new therapeutic interventions.