bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and prognostic features of MMP-2 and VEGF in AEG patients
Authors: Zheng Qing-Kang , Yin Qing , Zhang Nan , Sun Zhi-Gang 
Published: May 2021

Abstract
Adenocarcinoma of the esophagogastric junction (AEG) has been increased in recent years and has become a worldwide problem that seriously affects human health. The purpose of the study is to investigate the clinical and prognostic characteristics of the matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) expression in AEG patients. A total of 69 patients were enrolled in this study. The result showed that the high expression of MMP-2 was significantly associated with tumor differentiation (P < 0.05) and depth of invasion (pT, P < 0.05). The high expression of VEGF was significantly associated with pT (P < 0.05) and lymph node metastasis (pN, P < 0.05). There was a positive correlation between MMP-2 and VEGF expression (P < 0.01). The 5-year survival rate for the 69 AEG patients was 40.6% and it was significantly associated with tumor differentiation (P < 0.05), pN (P < 0.01), pTNM stage (P < 0.01), MMP-2 expression (P < 0.05), and VEGF expression (P < 0.05). Cox multivariate regression demonstrated that tumor differentiation and pN were independent factors for the 5-year survival rate. Our study showed that MMP-2 and VEGF could work synergistically in AEG development.
Correlation between MTHFR 677C > T polymorphism and response of pemetrexed-based chemotherapy in advanced NSCLC: A meta-analysis
Authors: Han Feng , Xu Wengui 
Published: May 2021

Abstract

Objective
The aim of this study was to investigate the correlation between MTHFR 677C > T polymorphism and response of pemetrexed-based chemotherapy in advanced non-small-cell lung cancer (NSCLC) by pooling the open published relevant studies.

Methods
Clinical studies associated with MTHFR 677C > T polymorphism and response of pemetrexed-based chemotherapy in advanced NSCLC were systematically searched in databases of Pubmed, Embase, Cochrance Library, China national knowledge infrastructure (CNKI) and Wanfang. The correlation was expressed by odds ratio (OR) and corresponding 95% confidence interval (95% CI). The publication bias of the included studies was evaluated through Begg’s funnel plot and Egger’s line regression test.

Results
Ten prospective clinical studies relevant to MTHFR 677C > T polymorphism and response of pemetrexed-based chemotherapy in NSCLC were included in the present meta-analysis. The pooled results indicated that the partial response in NSCLC patients with TT or CT genotype was inferior to CC genotype in a dominant gene model (TT + CT vs CC) (OR = 0.16, 95% CI: 0.06–0.41, P = 0.001). NSCLC cases with T genotype were inferior to C genotype in the objective response rate treated with pemetrexed-based chemotherapy for dominant (OR = 0.28, 95% CI: 0.18–0.45, P = 0.001), recessive (OR = 0.43, 95% CI: 0.19–0.94, P = 0.03) and homozygous models (OR = 0.30, 95% CI: 0.13–0.67, P = 0.003). However, there was no statistical difference in disease control rate, progressive disease between different genotypes of different gene models (P
all > 0.05).

Conclusion
The pemetrexed-based chemotherapy response was decreased in NSCLC cases with T genotype, which can be applied as a potential pemetrexed-based chemotherapy response marker.
Investigating the field effectiveness of respirators against metal particle exposure in various workplaces: a systematic review
Authors: Rafiee Ata , Laskar Imranul , Quémerais Bernadette 
Published: May 2021

Abstract
Welders are exposed to high levels of metal fumes, which could be resulting in various health impairments. Respirators became a practical protective option in workplaces, as they are lightweight and easy to use. This systematic review attempts to explore the field effectiveness of using respirators to reduce metal particle exposure in workplaces. We reviewed papers published from 1900 to April 2019 in five major bibliographic databases, including Embase, Web of Science, Medline, Scopus, and CINAHL, along with organizational websites to cover gray literature. In total, 983 references were identified from the databases, out of which, 520 duplicates were removed from the EndNote database. The remaining 463 references were screened for their title and abstract. Out of 463, 70 references went through the full-text screening. Finally, eight papers, including 19 workplace respirator studies, satisfied all the inclusion criteria and were reviewed in this report. The geometric means for metal levels in workers’ breathing zone with and without respirators were 9.4 and 1,777 µg/m3 for iron, 1.1 and 139 µg/m3 for lead, 2.1 and 242 µg/m3 for zinc, and 27 and 1,398 µg/m3 for manganese oxide, respectively. Most reviewed studies reported significant differences between measured metal particle levels among workers who worn respirators and who did not. In addition, results showed that N95 provided significantly less protection than elastomeric half facepieces, full-face respirators, and powered air-purifying respirators (p<0.001). More field studies are recommended to investigate Workplace Protection Factor (WPF) and fit factor (FF) of different respirators to understand the actual protection levels that they could be provided to control welding fume exposure among welders in various workplaces.
Role of stimulating growth factor 2 and galectin-3 in predicting the ventricular tachyarrhythmias in patients with ischemic cardiomyopathy
Authors: Atabekov T. A. , Batalov R. E. , Sazonova S. I. , Gusakova A. M. , Krivolapov S. N. , Khlynin M. S. , Popov S. V. 
Published: May 2021

Aim. To assess the role of stimulating growth factor 2 (ST-2) and galectin-3 in predicting the ventricular tachyarrhythmias (VTA) in patients with coronary artery disease (CAD) and left ventricular ejection fraction (LVEF) <35%.Material and methods. The study included 40 patients (men, 36 (90,0%); median age, 64,5 [57,5; 68,5] years) with CAD, NYHA class IIIII heart failure, LVEF <35%, indications for implantable cardioverter defibrillator (ICD) (primary prevention of sudden cardiac death). Prior to ICD implantation, patients were measured for serum ST-2 and galectin-3 levels. For 18 months, patients were assessed for arrhythmic events recorded in the ICD memory.Results. The 1st group consisted of 10 (25,0%) patients who had VTA episodes, arrested by antitachycardia pacing or shock during 18-month follow-up. The 2nd group consisted of 30 (75,0%) patients without VTA episodes. It was found that ST-2 concentration >22,48 ng/ml (p=0,02) and galectin-3 >10,95 ng/ml (p=0,009) corresponded to appropriate ICD discharge. Multivariate ROC analysis demonstrated that the only independent predictor of VTA was ST-2 elevation (odds ratio, 1,11; 95% CI, 1,01-1,21; p=0,023).Conclusion. An increase in the concentration of both ST-2 >22,48 ng/ml and galectin-3 >10,95 ng/ml had a high predictive value in assessing the VTA risk in patients with ischemic cardiomyopathy. In multivariate analysis, an increase in ST-2 >22,48 ng/ml was an independent predictor of VTA.
Ultrasound assessment of muscle mass in the diagnosis of sarcopenia in cardiovascular patients
Authors: Erokhina A. S. , Golovanova E. D. , Miloserdov M. A. 
Published: May 2021

Aim. To study the advantages of ultrasound versus anthropometric assessment of muscle mass for early diagnosis of sarcopenia in patients >45 years of age.Material and methods. The study included 79 patients aged 4589 years with coronary artery disease (CAD), hypertension, type 2 diabetes, heart failure, class 1-3 obesity. Diagnosis of hypertension was carried out according to the European (2018) and Russian (2019) guidelines; CAD — according to Russian Society of Cardiology (2020) guidelines. Sarcopenia was diagnosed according to 2010 European Working Group on Sarcopenia in Older People (EWGSOP) criteria and 2018 EWGSOP2 guidelines. Muscle mass (MM) was determined by two methods: 1 — by measuring the rectus abdominis muscle (RAM) thickness using the ultrasound; 2 — by measuring the arm and lower leg circumference. Muscle strength was determined by wrist dynamometer. Muscle function was assessed using the 4-m gait speed test.Results. The study showed that in patients aged >45 years admitted to the emergency cardiology department, the body mass index exceeded 25 kg/m2 in 88,6% of cases. The incidence of sarcopenia of varying severity was 55,7% (n=44). The differences in RAM thickness, arm and lower leg circumference between the groups of patients with/without sarcopenia were significant (p<0,001), but were less than the threshold only for RAM thickness. RAM thickness levels progressively decreased with increasing severity of sarcopenia and significantly differed at all stages compared to patients without sarcopenia (p<0,001), regardless of body mass index. A decrease in lower leg circumference below the threshold values determining a MM decrease was observed only in severe sarcopenia, and arm circumference — in both men and women only in severe sarcopenia. There were no significant differences for arm and lower leg circumference depending on sarcopenia stages in overweight and obese patients.Conclusion. MM assessment by measuring RAM thickness with ultrasound in comparison with the anthropometric method makes it possible to diagnose sarcopenia in patients >45 years of age with cardiovascular diseases and obesity at earlier stages and to promptly recommend preventive measures.
Anticoagulant therapy in patients with atrial fibrillation and an implanted cardiac resynchronization therapy device
Authors: Kirgizova M. A. , Savenkova G. M. , Kurlov I. O. , Krivolapov S. N. , Batalov R. E. , Popov S. V. 
Published: May 2021

Aim. To study the efficacy and safety of direct oral anticoagulant (DOAC) therapy after implantation of cardiac resynchronization therapy (CRT) devices in atrial fibrillation (AF) patients with coronary artery disease (CAD) and dilated cardiomyopathy (DCM).Material and methods. The study included 93 patients followed up from 2014 to 2016 (71 men and 22 women) aged 33-85 years (59,7±10,6) with stable CAD (group 1, n=44) and DCM (group 2, n=49). All patients were diagnosed with AF. The left ventricular ejection fraction (LVEF) was 30,6±3,8%; the left ventricular end-diastolic dimension was 230,9±60,8 mm. All patients received anticoagulants for the prevention of thromboembolic events: a vitamin K antagonist (warfarin) or DOAC. The analysis of medical records, as well as ECG records, echocardiographic, 24-hour ECG monitoring data and information from implanted device was carried out. The follow-up period lasted 24 months.Results. After 24-month follow-up, positive dynamics was noted in all patients — LVEF increased from 30,6±3,7% to 39,5±5,8%). In patients with DCM, a more pronounced increase in myocardial contractile function was noted. Stroke within time interval from 12 to 24 months developed in two patients taking warfarin, from different groups. Transient ischemic attacks were observed in 6 patients: in one patient from group 1 during the period from inclusion and 12-month visit, and in 5 patients from 12 to 24 months. Out of 5 patients, two belonged to group 1 and three — to group 2, while one patient took aspirin and the other 4 — warfarin. One patient from group 1 with persistent AF and vitamin K antagonist therapy had left atrial appendage thrombosis. Hemorrhagic strokes and major bleeding have not been reported.Conclusion. Among patients taking DOAC, regardless of the underlying disease (CAD or DCM) and response to CRT, bleeding events were less often recorded, and there were no thromboembolic events.
Predictors of unsuccessful endovascular recanalization of coronary chronic total occlusion
Authors: Vasiliev D. K. , Rudenko B. A. , Shanoyan A. S. , Shukurov F. B. , Feshchenko D. A. 
Published: May 2021

The prevalence of endovascular interventions for coronary chronic total occlusion (CTO) remains small worldwide. This is due to the complexity of procedure and the risk of intraoperative complications. In this regard, the search for predictors of unsuccessful endovascular intervention in CTO plays a special role. This will allow for a careful selection of patients with the most favorable expectation effect of the operation. Aim. To identify predictors of unsuccessful endovascular recanalization of CTO.Material and methods. This retrospective study included 180 patients with chronic coronary artery disease (CAD) in the period from November 2017 to June 2019, who had multivessel lesion in combination with CTO. In all patients, an attempt was made to achieve complete myocardial revascularization. Depending on the success of procedure, the patients were divided into two groups: complete and incomplete myocardial revascularization. The follow-up period was 12 months.Results. All baseline characteristics of patients in the compared groups were similar. The successful recanalization rate of occlusion was 79,5%. Multivariate regression analysis showed that calcified CTO (p<0,001), baseline SYNTAX (Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery) score >32 (p=0,006), CTO length >30 mm (p=0,046) and CTO of circumflex artery (p<0,01) are significant predictors of unsuccessful endovascular recanalization of CTO. To assess the predictive value of the model, a ROC analysis was carried out, and the area under the curve (AUC) was calculated. The AUC was 0,87, which indicates a high predictive quality of the model. The sensitivity and specificity of the model were 78 and 81%, respectively.Conclusion. The study showed that the presence of calcified CTO, SYNTAX score >32 points, CTO length >30 mm, and CTO of circumflex artery are significant predictors of unsuccessful CTO recanalization.
An insight into lung cancer: a comprehensive review exploring ALK TKI and mechanisms of resistance
Authors: Patcas Adela , Chis Ana Florica , Militaru Claudia Florentina , Bordea Roxana Ioana , Rajnoveanu Ruxandra , Coza Ovidiu Florin , Hanna Reem , Tiberiu Tamas , Todea Doina Adina 
Published: May 2021

Implementation of precision medicine in lung cancer has benefited from intense research in the past years, developing subsequently an improved quality of life and increased overall survival of the patients. Targeted therapy has become one of the most important therapeutic innovations for the non-small cell lung cancer (NSCLC) category with anaplastic lymphoma kinase (ALK) gene rearrangement. The aim of this review is to provide a through overview of the main molecules of ALK tyrosine kinase inhibitors (TKI) with their general and particular mechanisms of resistance, the main methods of ALK gene detection, each with advantages and limits and the future perspectives currently under research which try to overcome the mechanisms of resistance. We have used two of the most reliable medical databases EMBASE and PubMed to properly select the latest and the most relevant articles for this topic. Encouraged by the promising results, the clinical practice was enriched by the approval of tyrosine kinase inhibitor molecules, three generations being developed, each one with more powerful agents than the previous ones. Unfortunately, the resistance to TKI eventually occurs and it may be induced by several mechanisms, either known or unknown. Crizotinib was the most intensely studied TKI , becoming the first molecule approved into clinical practice and although four other drugs have been broadly used (alectinib, ceritinib, brigatinib and lorlatinib) it seems that even the most recently developed one remains imperfect due to the resistance mutations that developed. There are two types of resistance generally described for the entire class and for the particular drugs, but half of them remain unknown
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Development of GUI for Detetection of Eye Disorders in Infants
Authors: Et. al. Aditya Singh, 
Published: May 2021

Strabismus is one of the most common vision diseases in which the eyes do not properly align with each other when looking at an object. The condition may be present occasionally or constantly and if it is present during a large part of childhood, it may result in amblyopia or loss of depth perception. In contrast to manual diagnosis, automatic recognition can significantly reduce labor cost and increase diagnosis efficiency. In this paper, we propose to detect ICD-10-CM Code H50.9 unspecified strabismus using CNN and Image Processing techniques. There are four types of strabismus namely exotropia, esotropia, hypertropia and hypotropia which we aim to detect. We furthermore aim to introduce a GUI particularly into pediatric ophthalmology where obtaining relevant diagnostic information is taxing.
Intelligent Control Strategy to Enhance Power Smoothing of Renewable based Microgrid with Hybrid Energy Storage
Authors: Et. al. Yashwant Joshi, 
Published: May 2021

A stand-alone renewable based microgrid (MG) performance with a hybrid energy storage system has been examined in this work. Stand-alone MG system mainly consists of a solar photovoltaic (PV) and permanent magnet synchronous generator (PMSG) based wind system. The hybrid energy storage system is based on Ni-Metal- Hydride (NiMH) battery and a supercapacitor (SC). The paper's primary goal is to propose an artificial neural network (ANN) based control strategy for charging/discharging control of Ni-Metal- Hydride battery & supercapacitor. The proposed maximum power tracking techniques (MPPT) include perturb and observe (P& O) algorithm for solar PV system while optimum torque (OT) MPPT for PMSG based wind turbine. The ANN-based control mechanism can maintain the DC bus voltage constant and trigger the supercapacitor to limit the battery current when the battery charging/ discharging current reached its threshold value. The proposed model responds quickly to intermittent nature PV-wind power generation or load power variation.
Chilaiditi sendromu ve mide kanseri
Authors: ÖZDEMİR Serdar , ÖZKAN Abuzer 
Published: May 2021

Baş ve arkadaşları tarafından hazırlanan ve Derginizin 2019 yılı ilk sayısında yayınlanan, “Chilaiditi sendromu ve mide kanseri” başlıklı olgu sunumunu büyük bir ilgi ile okuduk (1). Yazarlara Chilaiditi sendromunun malignite ile birlikteliğini vurgulayan bu yazıdan dolayı teşekkür ederiz. Bununla birlikte olgunun tartışmasına katkı sunabilecek birkaç noktaya değinmek isteriz.
Her ne kadar Viyanalı radyolog Demetrius Chilaiditi tarafından 1911 yılında raporlanmış ve onun adıyla anılıyor olsa da, 1865 yılında Cantini tarafından, 1899 yılında ise Beclere tarafından bu sendromun otopsi bulguları ve röntgenografi bulguları subdiyafragmatik apse olgusunda bildirilmiştir. Bununla birlikte, literatürde asemptomatik hastalardan “Chilaiditi belirtisi”, semptomatik olgularda ise “Chilaiditi sendromu” olarak bahsedilmiştir (2). Demetrius Chilaiditi, modern radyolojinin öncülerindendir ve Türk Radyoloji Derneği'nin de ilk üyelerinden birisidir (3).
Kolonun hepatodiyafragmatik interpozisyonunun farklı anatomik alt tipleri tanımlanmıştır. Daha sıklıkla görülen alt tip; diyaframın önünde ve karaciğerin sağ lobunun üstünde, anterior subfrenik boşlukta kolonun bulunması şeklindedir. Posterior subfrenik boşlukta hepatodiyafragmatik interpozisyon nadir görülen bir alt tiptir. Kombine anterior ve posterior kolonik interpozisyon ise daha nadir görülmektedir (4).
Chilaiditi belirtisinin karakteristik üç radyolojik bulgusu; kolon veya ince barsak segmentlerinin diyafram ile karaciğer arasında yerleşmesi (semptomatik hastalarda segmentler sıklıkla dilatedir), sağ hemidiyafram elevasyonu, karaciğerin mediale yer değiştirmesi şeklindedir. Kolonik gaz imajının lateralde veya posteriorda yerleştiği, karaciğer üzerinde izlenmediği durumlar ise inkomplet hepatodiyafragmatik interpozisyon olarak isimlendirilir (5).
Chilaiditi sendromunun erken tanınması; bu nadir durumun, gereksiz cerrahi müdahalelere yol açarak, cerrahi acil bir durum olarak kabul edilen pnömoperitoneum ile karıştırılarak gereksiz cerrahi müdahalelere neden olabilmektedir. Özellikle röntgenografide sağ hemidiyafram altında gaz imajı izlenen ve pnömoperitoneum ile psödo-pnömoperitoneum ayrımı yapılmasında zorlanılan olgularda sağ hemidiyafram altındaki kolon haustrasını ortaya çıkaran sol lateral dekübitus pozisyonda çekilen grafiler yardımcı olabilir. Bilgisayarlı tomografinin tanısal olduğu kanıtlanmıştır (4,5).
A clinicopathological study of patients with sino nasal polyposis in tertiary care centre
Authors: Gowda P. R. Belure , Kumar M. V. Vinay 
Published: May 2021

<p class="abstract"><strong>Background:</strong> Masses in sino nasal cavity presents with wide range of complaints like nasal obstruction, nasal discharge, epistaxis, headache, swelling in and around the nose, through clinical examination, rigid nasal endoscopy and by use of advanced imaging technique computerized tomography (CT), magnetic resonance imaging (MRI) of nose and paranasal sinuses. Presumptive diagnosis is often made. However, it is a careful histopathological examination which divides the nature of any particular lesion, like neoplastic benign or malignant or non-neoplastic and inflammatory which makes possible to implement correct and timely intervention, which is a major dividing factor for better prognosis.</p><p class="abstract"><strong>Methods:</strong> A total of 100 cases of nasal polyps were studied by the department of ENT at Hassan institute of medical sciences, Hassan during a period of 1 year from January 2019 to January 2020. They were treated surgically by endoscopic excision, lateral rhinotomy or by radical surgery. All the excised masses were sent for histopathological examination to determine their final diagnosis.</p><p class="abstract"><strong>Results:</strong> The middle age group of 21 to 30 years was the most common age group affected with more male predominance. Nearly 85% of the cases were non-neoplastic. The most common presentation was nasal obstruction with ethmoidal sinus being the commonest sinuses seen in the present study.</p><p class="abstract"><strong>Conclusions:</strong> Polypoid lesions in the nasal cavity and paranasal sinuses may range widely from benign to malignant affecting all the ages. Common nasal lesions were seen in age group 21-30 years and maximum lesions were non- neoplastic.</p>
Controversies in Political Ideologies: A Critical Discourse Analysis of Speeches of Indian and Pakistani Premiers on Pulwama Incident
Authors: Shah Muhammad Imran , Ahmad Saeed Ahmad , Danishs Ali 
Published: May 2021

Critical Discourse Analysis (CDA) is considered an effective approach to exploring a text's hidden realities. The current research analyzes the speeches of the leaders of the two states on the incident of Pulwama attack on 14th February 2019 in the region of Indian occupied Kashmir to control the minds of the audience and formulate their ideologies to achieve their political benefits through power abuse. The data has been taken from the speeches delivered by both political leaders, the Premier of Pakistan Imran Khan and the Premier of India, Narendra Modi, on Pulwama Attack. Both qualitative and quantitative research approaches have been followed to investigate the texts. For Quantitative data, AntConc 3.5.8 has been utilized for the frequencies and concordance of the important words to be discussed. Observation has been utilized to gain in-depth information to describe qualitatively. The results show that some specific linguistic choices regarding some particular vocabulary, pronouns, and modal verbs have been used ideologically by the premiers to manipulate the language of their speeches. The study will be important for researchers who want to investigate the discourse developed by the political leaders’ speeches on the same issue.Keywords: discourse; pronoun; modality corpus; intertextuality