bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis on the Seismic Performance of Shock Absorption Layer Applied in Tunnel Lining Structure Using Shaking Table Model Tests
Authors: Wen Y. M. , Xin C. L. , Yin Z. H. , Huang Z. M. , Li X. M. , Wen H. Y. 
Published: October 2021

Abstract
Shock absorption layer is a relatively simple and effective aseismic measure, which can bear the adverse effects of surrounding rock deformations and buffer the forces acting on lining structure with seismic action. This paper conducts a series of shaking table model tests to analyze and compare the aseismic performances of tunnel lining structure with and without shock absorption layer in different grades of surrounding rocks, in which the superior thickness of shock absorption layer is determined. Therein, it is concluded that the shock absorption layer has prominent influence on reducing the acceleration responses of surrounding rock and lining structure with seismic excitation. The setting of the shock absorption layer can reduce the acceleration amplitude of tunnel lining with seismic excitation by about half. Furthermore, the setting of 1 cm shock absorption layer will increase the Fourier amplitudes and change the vibration frequencies of surrounding rock and lining structure with seismic excitation, while the setting of 2 cm shock absorption layer can significantly decrease the Fourier amplitudes and keep the vibration frequencies of surrounding rock and lining structure with seismic excitation. Therefore, the aseismic effect of 2 cm shock absorption layer is better than the aseismic effect of 1 cm shock absorption layer, which can both reduce the acceleration amplitude and Fourier amplitude of tunnel lining with seismic excitation while keep its characteristics in frequency domain. This research on the aseismic performance of shock absorption layer can contribute to the construction of tunnel engineering and improve the safety of tunnel lining structure.
Developing the Patient Falls Risk Report: A mixed methods study on sharing falls-related clinical information from home care with primary care providers
Authors: Nova Amanda Aguilar da 
Published: October 2021

Abstract
Background: The interRAI home care (interRAI-HC) instrument is valid, reliable, and capable of enhancing integration across health settings. However, its uptake has been met with criticism. If interRAI-HC information were shared with primary care providers in a useable, actionable, and context-appropriate manner, evidence suggests that its implementation could enhance care provision and integration between these providers. The objective of this study was to co-develop an information sharing tool with primary care providers for sharing clinical information from the interRAI-HC (named the Patient Falls Risk Report). Methods: This mixed-methods study, conducted from December 2019 to May 2020, employed qualitative and quantitative methods to develop and test the usability of the Patient Falls Risk Report. After recruiting primary care providers via snowball and maximum variation sampling, we employed semi-structured interviews in-person and over the telephone. The interview transcripts were analyzed through iterative thematic analysis and informed development of the report. Next, online surveys based on the System Usability Scale instrument were completed by a voluntary response sample of primary care providers and residents and descriptively analyzed to test the usability of the report.Results: Of the interview sample (n=9), we found that most believed that the Patient Falls Risk Report could support patient care by sharing relevant and actionable falls-related information. However, criticisms were identified including insufficient detail, lack of clarity, and limited support for shared care planning. After incorporating participants’ suggestions for improvement, a sample of primary care providers and primary care residents (n=27) determined that the report had excellent usability with an overall usability score of 83.4 (95% CI = 78.7, 88.2). Conclusions: By emphasizing usability and utility, and prioritizing the needs of end-users, sustainable interRAI-HC interventions can be developed and implemented to support care planning in primary care.
Identification of Crucial Genes of Pyrimidine Metabolism as Biomarkers for Gastric Cancer Prognosis
Authors: Wu Zhengxin , Tan Jinshui , Zhuang Yifan , Zhong Mengya , Xiong Yubo , Ma Jingsong , Yang Yan , Gao Zhi , Zhao Jiabao , Ye Zhijian , Zhou Huiwen , Zhu Yuekun , Lu Haijie , Hong Xuehui 
Published: October 2021

Abstract
Background
Metabolic reprogramming has been reported in various kinds of cancers and is related to clinical prognosis, but the prognostic role of pyrimidine metabolism in gastric cancer (GC) remains unclear.
Methods
Here, we employed DEG analysis to detect the differentially expressed genes (DEGs) in pyrimidine metabolic signaling pathway and used univariate Cox analysis, Lasso-penalizes Cox regression analysis, Kaplan-Meier survival analysis, univariate and multivariate Cox regression analysis to explore their prognostic roles in GC. The DEGs were experimentally validated in GC cells and clinical samples by quantitative real-time PCR.
Results
Through DEG analysis, we found NT5E, DPYS and UPP1 these three genes are highly expressed in GC. This conclusion has also been verified in GC cells and clinical samples. A prognostic risk model was established according to these three DEGs by Univariate Cox analysis and Lasso-penalizes Cox regression analysis. Kaplan-Meier survival analysis suggested that patient cohorts with high risk score undertook a lower overall survival rate than those with low risk score. Stratified survival analysis, Univariate and multivariate Cox regression analysis of this model confirmed that it is a reliable and independent clinical factor. Therefore, we made nomograms to visually depict the survival rate of GC patients according to some important clinical factors including our risk model.
Conclusion
In a word, our research found that pyrimidine metabolism is dysregulated in GC and established a prognostic model of GC based on genes differentially expressed in pyrimidine metabolism.
Dosimetric Effect of Respiratory Motion On Planned Dose In Whole-Breast Volumetric Modulated Arc Therapy Using Standard And Ultra-Hypofractionation
Authors: Mankinen Mikko , Virén Tuomas , Seppälä Jan , Hakkarainen Heikki , Koivumäki Tuomas 
Published: October 2021

Abstract
Background and purpose: The interplay effects of respiratory motion and MLC movement on the planned dose in right-sided whole-breast irradiation (WBI) were studied by simulating hypofractionated VMAT treatment courses.Materials and methods: Ten patients with phase-triggered 4D-CT images were included in the study. VMAT plans targeting the right breast were created retrospectively with prescription doses of 26 Gy (5 fractions) and 40.05 Gy (15 fractions). 3D-CRT plans were generated as a reference. All plans were divided into respiratory phase-specific plans in fraction-by-fraction basis. The phase-specific dose distributions were deformed and superimposed onto the planning image, forming the course-specific, respiratory motion perturbed dose distribution. Distributions were compared with the original plans and changes due to respiratory motion and choice of fractionation were evaluated.Results: The respiratory motion perturbed PTV coverage (V95%) decreased by 1.7% and the homogeneity index increased by 0.02 for VMAT techniques, compared to the planned values. Highest decrease in CTV coverage was 0.7%. The largest dose differences were located in the areas of steep dose gradients parallel to respiratory motion. The largest difference in DVH parameters between fractionation schemes was 0.4% of the prescribed dose. Clinically relevant changes to the doses of organs at risk were not observed.Conclusion: The VMAT techniques were found feasible for WBI with 5 and 15-fraction treatments in terms of respiratory motion induced error. The CTV dose coverage was retained despite the decrease in PTV coverage. No clinical significance was found due to the choice of fractionation.
Neuromorphic object localization using resistive
memories and ultrasonic transducers
Authors: Moro Filippo , Hardy Emmanuel , Fain Bruno , Dalgaty Thomas , Clemencon Paul , De Prá Alessio , Castellani Niccolò , Blard Francois , Gardien Francois , Mesquida Thomas , Rummens Francois , Esseni David , Casas Jérôme , Indiveri Giacomo , Payvand Melika , Vianello Elisa 
Published: October 2021

Abstract
Real-world sensory-processing applications require compact, low-latency, and low-power computing systems. Enabled by their in-memory event-driven computing abilities, hybrid memristive-CMOS neuromorphic architectures provide an ideal hardware substrate for such tasks. To demonstrate the full potential of such systems, we propose and experimentally demonstrate an end-to-end sensory processing solution for a real-world object localization application. Drawing inspiration from the barn owl’s neuroanatomy, we developed a bio-mimetic, event-driven object localization system that couples state-of-the-art piezoelectric micromachined ultrasound transducer (pMUT) sensors to a neuromorphic resistive memories-based computational map. We present measurement results from the fabricated system comprising resistive memories-based coincidence detectors, delay line circuits, and a full-custom pMUT sensor. We use these experimental results to calibrate our system-level simulations. These simulations are then used to estimate the angular resolution and energy efficiency of the object localization model. The results reveal the potential of our approach, evaluated in orders of magnitude greater energy efficiency than a microcontroller performing the same task.
Preclinical Evaluation of [99mTc]Tc-Labeled Anti-EpCAM Nanobody for EpCAM Receptor Expression Imaging By Immuno-SPECT/CT
Authors: Liu Tianyu , Wu Yue , Shi Linqing , Li Liqiang , Hu Biao , Wang Yanpu , Gao Hannan , Yu Xiaolu , Zhang Xin , Zhao Huiyun , Wan Yakun , Jia Bing , Wang Fan 
Published: October 2021

Abstract
Purpose Overexpression of epithelial cell adhesion molecule (EpCAM) plays essential roles in tumorigenesis and tumor progression in almost all epithelium-derived cancer. Monitoring EpCAM expression in tumors can be used for the diagnosis, staging and prognosis of cancer patients, as well as guiding the individualized treatment of EpCAM-targeted drugs. In this study, we described the synthesis and evaluation of a site-specifically [99mTc]Tc-labeled EpCAM-targeted nanobody for the SPECT/CT imaging of EpCAM expression. Methods We first prepared the [99mTc]Tc-HYNIC-G4K, then it was site-specifically connected to EpCAM-targeted nanobody NB4. The in vitro characteristics of [99mTc]Tc-NB4 were investigated in HT-29 (EpCAM-positive) and HL-60 (EpCAM-negative) cells, while the in vivo studies were performed using small-animal SPECT/CT in the subcutaneous tumor models and the lymph node metastasis model to verify the specific targeting capacity as well as the potential applications of [99mTc]Tc-NB4. Results [99mTc]Tc-NB4 displayed a high EpCAM specificity both in vitro and in vivo. SPECT/CT imaging revealed that [99mTc]Tc-NB4 was cleared rapidly from the blood and normal organs except for the kidneys, and HT-29 tumors were clearly visualized in contrast with HL-60 tumors. The uptake value of [99mTc]Tc-NB4 in HT-29 tumors was increased continuously from 3.77 ± 0.39 %ID/g at 0.5 h to 5.53 ± 0.82 %ID/g at 12 h after injection. Moreover, the [99mTc]Tc-NB4 SPECT/CT could clearly image tumor-infiltrating lymph nodes. Conclusion [99mTc]Tc-NB4 is a broad-spectrum, specific and sensitive SPECT radiotracer for the noninvasive imaging of EpCAM expression in the epithelium-derived cancer, and revealed a great potential for the clinical translation.
Improved prediction of protein-protein interactions using AlphaFold2
Authors: Bryant Patrick , Pozzati Gabriele , Elofsson Arne 
Published: October 2021

Abstract
Predicting the structure of interacting protein chains is fundamental for understanding the function of proteins. Here, we examine the use of AlphaFold2 (AF2) for predicting the structure of heterodimeric protein complexes. We find that using the default AF2 protocol, 44% of the models in a test set can be predicted accurately. However, by optimising the multiple sequence alignment, we can increase the accuracy to 59%. In comparison, the alternative fold-and-dock method RoseTTAFold is only successful in 10% of the cases on this set, template-based docking 35% and traditional docking methods 22%. We can distinguish acceptable (DockQ>0.23) from incorrect models with an AUC of 0.85 on the test set by analysing the predicted interfaces. The success is higher for bacterial protein pairs, pairs with large interaction areas consisting of helices or sheets, and many homologous sequences. Further, we test the possibility to distinguish interacting from non-interacting proteins and find that by analysing the predicted interfaces, we can separate truly interacting from non-interacting proteins with an AUC of 0.82 in the ROC curve, compared to 0.76 with a recently published method. In addition, when using a more realistic negative set, including mammalian proteins, the identification rate remains (AUC=0.83), resulting in that 27% of interactions can be identified at a 1% FPR. All scripts and tools to run our protocol are freely available at: https://gitlab.com/ElofssonLab/FoldDock.
Quality of Knee Strengthening Exercises Performed at Home Deteriorates After One Week
Authors: Mitchell Ulrike H. , Lee Hyunwook , Dennis Hayden E. , Seeley Matthew K. 
Published: October 2021

Abstract
Background: To compare the performance (as determined by lower extremity kinematics) of knee exercises in healthy middle-aged and older individuals immediately after instruction and one week later. Methods: This is a cross-sectional study in a laboratory setting. Nineteen healthy volunteers (age [y] 63.1 ± 8.6, mass [kg] 76.3 ± 14.7, height [m] 1.7 ± 0.1) participated in this study. High speed video and reflective markers were used to track motion during four exercises. The exercises were knee flexion, straight leg raise, and “V“ in supine position, and hip abduction in side lying position. All participants received verbal and tactile cues during the training phase and the therapist observed and, if necessary, corrected the exercises. Upon return a week later the participants performed the same exercises without any further instructions. Knee and hip sagittal and rotational angles were extracted from the motion capture. A repeated measures t-test was used to compare the motions between two visits. Results: Participants demonstrated more knee flexion during straight leg raise and “V in” exercises at the 2nd visit compared to the 1st visit (both p < 0.05). During the “V out” exercise, they performed more external rotation (p < 0.05) while they showed more internal rotation during the “V in” exercise at the 2nd visit compared to the 1st visit. Conclusions: Exercise performance declined significantly in healthy middle-aged and older individuals one week after instruction. This decline occurred despite an instructional exercise sheet being given to every participant. Improper execution of exercise programs might prolong the rehabilitation time and increase levels of pain and impairment unnecessarily.
Optimal Overlays for Preservation of Concrete Slabs in Cold Climate: Decision Making by the Method of Fuzzy Comprehensive Evaluation Combined with AHP
Authors: Li Zhipeng , Dang Yudong , Tang Zhen , Xie Ning , Lu Shuang , Shi Xianming 
Published: October 2021

Abstract
Overlays have been extensively employed as an effective preservation or rehabilitation tool to extend the service life of concrete bridges and pavements, especially these deteriorated concrete slabs suffering from salt scaling and abrasion. However, limited attention has been paid to the durability and performance of these overlays which can be jeopardized when they are exposed to freeze/thaw-wet/dry cycles, deicer applications, studded tires, and their coupled effects as well. Various overlays feature different engineering properties, and they might be only effective in specific service environments but not others, and research is lacking to examine the adaptation of various overlays in different environments. This study subjected five overlay products on concrete slabs to the combined action of freeze/thaw (F/T) and wet/dry (W/D) cycles with periodical exposure to either 15 wt.% NaCl solution or 15 wt.% MgCl2 solutions, to simulate the typical field scenarios in an accelerated manner. The bond strength, splitting tensile strength, and abrasion resistance of the overlaid concrete slabs were tested to evaluate the effectiveness of various overlays against the deicer scaling and the abrasion by studded tires. Based on the experimental data, this study demonstrated a multi-criteria decision making method, fuzzy comprehensive evaluation (FCE) combined with analytic hierarchy process (AHP), for the selection of optimal overlays in three different service scenarios (e.g., states of Washington and Oregon [USA] and British Columbia [Canada]). The analysis results indicated that one epoxy overlay exhibited the comprehensively best performance and could be a promising candidate in all three given scenarios, another polymer overlay took second place, while the adaptability of the three cement-based overlays varied in different environments.
Measuring and tailoring Li-ion interfacial transport in hybrid solid electrolytes
Authors: Liu Ming , Eck Ernst van , Ganapathy Swapna , Wagemaker Marnix 
Published: October 2021

Abstract
Development of commercial solid-state batteries so far been hindered by the individual limitations of inorganic and organic solid-electrolytes, motivating hybrid concepts. However, room-temperature performance of hybrid-solid electrolytes is still insufficient in terms of ion conductivity, where especially the role and impact of the inorganic and organic interphases is largely unexplored. A key challenge is to assess the Li-ion transport over the interfaces directly and relate this to the surface chemistry. Here the lithium-ion conductivity in hybrid-solid electrolytes, the interface structure and Li+ interface transport was investigated by state-of-art solid-state nuclear magnetic resonance methodologies. In a hybrid-solid Polyethylene oxide polymer – inorganic electrolyte, two representative types of ionic liquids, having a different miscibility with the polymer, were used as a benchmark to tailor the local environment at the interface between the inorganic and organic solid electrolytes species. The poor miscibility ionic liquid wets the polymer-inorganic interface and raises the local polarizability, thereby lowering the diffusional barrier, which activates the high conductivity of the inorganic solid-electrolyte, resulting in and overall room temperature conductivity of 0.25 mS/cm. A very high critical current density of 0.25 mA/cm2 versus a Li-metal anode is achieved, demonstrating improved stability, and a LiFePO4 – Li-metal full solid-state cell can be cycled at room temperature at an Coulombic efficiency of 99.9%. The local interface environment between the solid electrolyte phases in hybrid solid electrolytes, is thus demonstrated to be the bottleneck and tailoring the interface properties appears a viable route towards the design of highly conducting hybrid-solid electrolyte concepts.
Post-exercise Stretching Protects Strain of Knee Joint Movement System by Relieving Knee Pain and Iliotibial Band Tension
Authors: Yin Le , Zhu Li-ming , Zhou Ye-qi , Ma Hai-tao 
Published: October 2021

Abstract
Background Studies have reported that exercise stretching therapy has a certain effect on improving knee joint pain and knee joint function.However, few studies have compared the effects of post-exercise stretching and non-stretching on strain of knee joint movement system. The purpose of this study is to observe the influence of whether people have stretched after exercise on knee joint pain and iliotibial band tension,and to compare the difference between the stretched group and the unstretched group after exercise for further discussion.Methods Collecting data analysis of 71 people who love sports in the First People's Hospital of Xiaoshan District from December 2019 to October 2020, including the non-stretching group after exercise (group A, n=40) and post-exercise stretching Group (Group B, n=31), compare the differences in knee pain and iliotibial band tension between the two groups and analyze the relationship between this difference and stretching.Results The incidence of knee pain and iliotibial band tension in group A was significantly higher than that in group B (P<0.05). The risk of knee pain in group A was 2.940 times greater than that in group B. The incidence of iliotibial band tension in group A was 4.190 times higher than that in group B. Conclusions 1. People who do not stretch after exercise are at higher risk of knee pain than those who stretch. 2. People who do not stretch are more likely to develop iliotibial band tension than those who stretch. 3. Stretching after exercise helps to relieve the stiffness of the iliotibial band, maintain the stability of the knee joint, and reduce the occurrence of knee pain.
The Role of Female’s Participation in Economic Activity to Household Income The Case of Mizan Aman Town, South Nation Nationality And People’s Region, Ethiopia
Authors: Ahmed Kemal Omer 
Published: October 2021

Abstract
The main aim of the study was to examine the role of females' economic participation in household income. To achieve this objective both primary and secondary sources of data were collected from 400 sample size using simple random sampling method. The obtained data were first analyzed using a descriptive method to describe socio-economic characteristics of women in the study area. Secondly, to identify determinants of women’s participation in economic activities and household decision-making process logit model was employed and finally, multiple linear regression method was applied to identify factors affecting the level of women's contribution to household income. The result shows that female participation in economic activities positively determines by women's training and woman’s education level and is negatively affected by the presence of children under five years of age. The contribution of women to household income on average was estimated birr 32,400.50 per annum which was nearly 36.8percent of the overall household income. The possible recommendation is government and other respective bodies must encourage women to learn more and more.