bluuebunny/crossref_metadata_2025_split huggingface dataset:
PELATIHAN (WORKSHOP) DAN SOSIALISASI MENGENAI TANAMAN HIDROPONIK DI KELURAHAN KEBON PALA KOTA ADMINISTRASI JAKARTA TIMUR TAHUN 2021
Authors: Ulinata Ulinata , Putri Dianty Grace , Evangelista Nanjan Array , Febronia Penate Boik Maria , Cosella Dea 
Published: November 2021

Program Studi Arsitektur Fakultas Teknik UKI melakukan kegiatan Pengabdian kepada Masyarakat dengan melanjutkan kegiatan Pengabdian kepada Masyarakat sebelumnya dengan tema Green Action 23 : Pelatihan (Workshop) dan Sosialiasi Mengenai Tanaman Hiidroponik di Kelurahan Kebon Pala Kota Administrasi Jakarta Timur Tahun 2021 yang sebelumnya diadakan hanya di RW 09 saja.
Kegiatan Pengabdian kepada Masyarakat ini bertujuan untuk memberikan edukasi mengenai bagaimana cara menanam hidroponik, dan apa saja manfaat menanam hidroponik.
Metode yang dilakukan adalah mengadakan Pelatihan (Workshop) dan Sosialiasi mengenai tanaman hidroponik dengan mengundang narasumber yang pakar di bidang hidroponik sehingga para peserta memperoleh edukasi mengenai bagaimana cara menanam hidroponik, dan apa saja manfaat menanam hidroponik yang diharapkan peserta dapat secara mandiri menanam hidroponik dan menularkannya kepada tetangga di lingkungan sekitar, kerabat, keluarga dan saudaranya.
Prosesnya dengan mempraktekkan langsung kepada peserta dengan menggunakan alat dan bahan yang akan disediakan diantaranya bak nutrisi dan tutup bak hidroponik, pupuk nutrisi AB mix Puriegarden, Suntikan Menakar Nutrisi, Benih, Netpot Bersumbu, Kain Kasa, Tusuk Gigi, Selang, Netpot Bersumbu, Airator, Flanel potong, Rockwool, TDS yang dibagikan kepada para peserta dengan memberikan sesi tanya jawab kepada para peserta yang membutuhkan penjelasan lebih lanjut.
Edukasi Kesehatan tentang Upaya Pencegahan dan Penanganan Aspirasi Benda Asing dan Kejang Demam pada Anak di Rumah
Authors: Damanik Sri Melfa , Sitorus Erita , Mertajaya I Made 
Published: November 2021

ABSTRAK
Masalah kegawatan aspirasi benda asing atau tersedak dan kejang demam pada anak usia Toddler merupakan salah satu kondisi kegawatan yang serius pada anak dan mengancam nyawa bila tidak ditangani segera. Observasi oleh pengasuh khususnya orangtua sangat penting dilakukan pada periode usia anak pada periode ini. Penanganan aspirasi benda asing dan kejang demam pada anak pre hospital dengan cepat dan tepat dapat mencegah peningkatan insiden morbiditas dan mortalitas anak. Tujuan Pelaksanaan Pengabdian kepada Masyarakat (PKM) ini yaitu untuk meningkatkan pengetahuan dan ketrampilan orangtua ibu tentang pencegahan dan penanganan aspirasi benda asing dan kejang demam pada anak Toddler di rumah. Sebanyak 30 ibu yang memiliki anak Toddler ikut dalam kegiatan PKM ini. Metode pelaksanaan PKM yaitu edukasi kesehatan secara daring melalui Zoom yang dikombinasikan dengan survei secara kuantitatif tentang pengetahuan ibu dalam melakukan pencegahan dan penanganan aspirasi benda asing dan kejang demam pada anak. Hasil PKM menunjukkan terdapat perbedaan yang signifikan antara nilai pre dan posttest pengetahuan ibu setelah diberikan sosialisasi (P<0,001). Kegiatan edukasi kesehatan kepada orangtua khusunya ibu atau pengasuh tentang pencegahan dan penanganan aspirasi benda dan kejang demam di rumah merupakan salah satu cara yang efektif untuk mengurangi angka morbiditas dan mortalitas pada anak di Indonesia.
Kata Kunci : Toddler, kejang demam, aspirasi benda asing. Peran Ibu
Saccade and Fixation Eye Movements During Walking in People With Mild Traumatic Brain Injury
Authors: Lirani-Silva Ellen , Stuart Samuel , Parrington Lucy , Campbell Kody , King Laurie 
Published: November 2021

Background: Clinical and laboratory assessment of people with mild traumatic brain injury (mTBI) indicate impairments in eye movements. These tests are typically done in a static, seated position. Recently, the use of mobile eye-tracking systems has been proposed to quantify subtle deficits in eye movements and visual sampling during different tasks. However, the impact of mTBI on eye movements during functional tasks such as walking remains unknown.Objective: Evaluate differences in eye-tracking measures collected during gait between healthy controls (HC) and patients in the sub-acute stages of mTBI recovery and to determine if there are associations between eye-tracking measures and gait speed.Methods: Thirty-seven HC participants and 67individuals with mTBI were instructed to walk back and forth over 10-m, at a comfortable self-selected speed. A single 1-min trial was performed. Eye-tracking measures were recorded using a mobile eye-tracking system (head-mounted infra-red Tobbii Pro Glasses 2, 100 Hz, Tobii Technology Inc. VA, United States). Eye-tracking measures included saccadic (frequency, mean and peak velocity, duration and distance) and fixation measurements (frequency and duration). Gait was assessed using six inertial sensors (both feet, sternum, right wrist, lumbar vertebrae and the forehead) and gait velocity was selected as the primary outcome. General linear model was used to compare the groups and association between gait and eye-tracking outcomes were explored using partial correlations.Results: Individuals with mTBI showed significantly reduced saccade frequency (p = 0.016), duration (p = 0.028) and peak velocity (p = 0.032) compared to the HC group. No significant differences between groups were observed for the saccade distance, fixation measures and gait velocity (p &gt; 0.05). A positive correlation was observed between saccade duration and gait velocity only for participants with mTBI (p = 0.025).Conclusion: Findings suggest impaired saccadic eye movement, but not fixations, during walking in individuals with mTBI. These findings have implications in real-world function including return to sport for athletes and return to duty for military service members. Future research should investigate whether or not saccade outcomes are influenced by the time after the trauma and rehabilitation.
TEMPO-Oxidized Cellulose Nanofiber-Alginate Hydrogel as a Bioink for Human Meniscus Tissue Engineering
Authors: Lan Xiaoyi , Ma Zhiyao , Szojka Alexander R. A. , Kunze Melanie , Mulet-Sierra Aillette , Vyhlidal Margaret J. , Boluk Yaman , Adesida Adetola B. 
Published: November 2021

Objective: The avascular inner regions of the knee menisci cannot self-heal. As a prospective treatment, functional replacements can be generated by cell-based 3D bioprinting with an appropriate cell source and biomaterial. To that end, human meniscus fibrochondrocytes (hMFC) from surgical castoffs of partial meniscectomies as well as cellulose nanofiber-alginate based hydrogels have emerged as a promising cell source and biomaterial combination. The objectives of the study were to first find the optimal formulations of TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl)-oxidized cellulose nanofiber/alginate (TCNF/ALG) precursors for bioprinting, and then to use them to investigate redifferentiation and synthesis of functional inner meniscus-like extracellular matrix (ECM) components by expanded hMFCs.Methods: The rheological properties including shear viscosity, thixotropic behavior recovery, and loss tangent of selected TCNF/ALG precursors were measured to find the optimum formulations for 3D bioprinting. hMFCs were mixed with TCNF/ALG precursors with suitable formulations and 3D bioprinted into cylindrical disc constructs and crosslinked with CaCl2 after printing. The bioprinted constructs then underwent 6 weeks of in vitro chondrogenesis in hypoxia prior to analysis with biomechanical, biochemical, molecular, and histological assays. hMFCs mixed with a collagen I gel were used as a control.Results: The TCNF/ALG and collagen-based constructs had similar compression moduli. The expression of COL2A1 was significantly higher in TCNF/ALG. The TCNF/ALG constructs showed more of an inner meniscus-like phenotype while the collagen I-based construct was consistent with a more outer meniscus-like phenotype. The expression of COL10A1 and MMP13 were lower in the TCNF/ALG constructs. In addition, the immunofluorescence of human type I and II collagens were evident in the TCNF/ALG, while the bovine type I collagen constructs lacked type II collagen deposition but did contain newly synthesized human type I collagen.
Bioprinting of Collagen Type I and II via Aerosol Jet Printing for the Replication of Dense Collagenous Tissues
Authors: Gibney Rory , Ferraris Eleonora 
Published: November 2021

Collagen has grown increasingly present in bioprinting, however collagen bioprinting has mostly been limited to the extrusion printing of collagen type I to form weak collagen hydrogels. While these weak collagen hydrogels have their applications, synthetic polymers are often required to reinforce gel-laden constructs that aim to replicate dense collagenous tissues foundin vivo. In this study, aerosol jet printing (AJP) was used to print and process collagen type I and II into dense constructs with a greater capacity to replicate the dense collagenous ECM found in connective tissues. Collagen type I and II was isolated from animal tissues to form solutions for printing. Collagen type I and II constructs were printed with 576 layers and measured to have average effective elastic moduli of 241.3 ± 94.3 and 196.6 ± 86.0 kPa (±SD), respectively, without any chemical modification. Collagen type II solutions were measured to be less viscous than type I and both collagen type I and II exhibited a drop in viscosity due to AJP. Circular dichroism and SDS-PAGE showed collagen type I to be more vulnerable to structural changes due to the stresses of the aerosol formation step of aerosol jet printing while the collagen type II triple helix was largely unaffected. SEM illustrated that distinct layers remained in the aerosol jet print constructs. The results show that aerosol jet printing should be considered an effective way to process collagen type I and II into stiff dense constructs with suitable mechanical properties for the replication of dense collagenous connective tissues.
Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure
Authors: Badash Ido , Quiñones Patricia M. , Oghalai Kevin J. , Wang Juemei , Lui Christopher G. , Macias-Escriva Frank , Applegate Brian E. , Oghalai John S. 
Published: November 2021

After acoustic trauma, there can be loss of synaptic connections between inner hair cells and auditory neurons in the cochlea, which may lead to hearing abnormalities including speech-in-noise difficulties, tinnitus, and hyperacusis. We have previously studied mice with blast-induced cochlear synaptopathy and found that they also developed a build-up of endolymph, termed endolymphatic hydrops. In this study, we used optical coherence tomography to measure endolymph volume in live CBA/CaJ mice exposed to various noise intensities. We quantified the number of synaptic ribbons and postsynaptic densities under the inner hair cells 1 week after noise exposure to determine if they correlated with acute changes in endolymph volume measured in the hours after the noise exposure. After 2 h of noise at an intensity of 95 dB SPL or below, both endolymph volume and synaptic counts remained normal. After exposure to 2 h of 100 dB SPL noise, mice developed endolymphatic hydrops and had reduced synaptic counts in the basal and middle regions of the cochlea. Furthermore, round-window application of hypertonic saline reduced the degree of endolymphatic hydrops that developed after 100 dB SPL noise exposure and partially prevented the reduction in synaptic counts in the cochlear base. Taken together, these results indicate that endolymphatic hydrops correlates with noise-induced cochlear synaptopathy, suggesting that these two pathologic findings have a common mechanistic basis.
The Impact of Harsh Parenting on the Development of Obesity in Adulthood: An Examination of Epigenetic/Gene Expression Mediators Among African American Youth
Authors: Lei Man-Kit , Beach Steven R. H. , Simons Ronald L. , Ye Kaixiong 
Published: November 2021

Objective: We examined the association of prospectively assessed harsh parenting during adolescence with body mass index (BMI) in young adulthood among African American youth. We also assessed the role of methylation of obesity-related genes and gene expression markers of obesity as mediators of this association, providing a pathway for the biological embedding of early harsh parenting and its long-term impact on young adult health.Methods: Hypotheses were tested with a sample of 362 African American youth for whom harsh parenting was assessed at ages 10–15, BMI was assessed at age 10 and 29, and both DNA methylation (DNAm) and gene expression of obesity genes were assessed at age 29. Mediational analyses were conducted using bootstrap methods to generate confidence intervals.Results: Controlling for genetic risk for obesity and health-related covariates, harsh parenting across childhood and adolescence was associated with change in BMI (Δ BMI) from ages 10–29. In addition, we found that the indirect effect of harsh parenting on Δ BMI was mediated through obesity-related DNAm and accounted for 45.3% of the total effect. Further, obesity-related DNAm mediated the effect of harsh parenting on gene expression of obesity-related genes (GEOG), and GEOG, in turn, mediated the impact of obesity-related DNAm on ΔBMI. This pathway accounted for 3.4% of the total effect. There were no gender differences in the magnitude of this indirect effect.Conclusions: The results suggest that alterations in methylation and gene expression mediate the impact of harsh parenting on change in obesity from childhood to young adulthood, illustrating plausible biological pathways from harsh parenting to obesity and bolstering the hypothesis that harsh parenting in childhood and adolescence can become biologically embedded and contribute to obesity.
Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort
Authors: Mandry Damien , Girerd Nicolas , Lamiral Zohra , Huttin Olivier , Filippetti Laura , Micard Emilien , Ncho Mottoh Marie-Paule Bernadette , Böhme Philip , Chemla Denis , Zannad Faïez , Rossignol Patrick , Marie Pierre-Yves 
Published: November 2021

Introduction: This study aims to assess the changes in cardiovascular remodeling attributable to bodyweight gain in a middle-aged abdominal obesity cohort. A remodeling worsening might explain the increase in cardiovascular risk associated with a dynamic of weight gain.Methods: Seventy-five middle-aged subjects (56 ± 5 years, 38 women) with abdominal obesity and no known cardiovascular disease underwent MRI-based examinations at baseline and at a 6.1 ± 1.2-year follow-up to monitor cardiovascular remodeling and hemodynamic variables, most notably the effective arterial elastance (Ea). Ea is a proxy of the arterial load that must be overcome during left ventricular (LV) ejection, with increased EA resulting in concentric LV remodeling.Results: Sixteen obese subjects had significant weight gain (&gt;7%) during follow-up (WG+), whereas the 59 other individuals did not (WG–). WG+ and WG– exhibited significant differences in the baseline to follow-up evolutions of several hemodynamic parameters, notably diastolic and mean blood pressures (for mean blood pressure, WG+: +9.3 ± 10.9 mmHg vs. WG–: +1.7 ± 11.8 mmHg, p = 0.022), heart rate (WG+: +0.6 ± 9.4 min−1 vs. −8.9 ± 11.5 min−1, p = 0.003), LV concentric remodeling index (WG: +0.08 ± 0.16 g.mL−1 vs. WG−: −0.02 ± 0.13 g.mL−1, p = 0.018) and Ea (WG+: +0.20 ± 0.28 mL mmHg−1 vs. WG−: +0.01 ± 0.30 mL mmHg−1, p = 0.021). The evolution of the LV concentric remodeling index and Ea were also strongly correlated in the overall obese population (p &lt; 0.001, R2 = 0.31).Conclusions: A weight gain dynamic is accompanied by increases in arterial load and load-related concentric LV remodeling in an isolated abdominal obesity cohort. This remodeling could have a significant impact on cardiovascular risk.
Invalid Data Rejection of Audible Noise on AC Transmission Lines Based on Moving Window Kernel Principal Component Analysis
Authors: Cheng Ziyi , Li Zhenhua , Huang Yuehua , Yao Weifang , Xie Huichun 
Published: November 2021

The statistical characteristics of the nighttime noise data of 1000 kV AC transmission lines were investigated, the noise data of the Huainan-Shanghai 1000 kV AC transmission line collected at night (0:00 to 6:00) from September 25, 2015, to February 16, 2016, were statistically analyzed using the nonparametric statistical K-S test, and the outliers were detected using the moving window kernel principal component analysis (MWKPCA). The results show that after the ineffective data are removed by MWKPCA, the 5, 50, and 95% values of the data are basically unchanged. To a certain extent, the method proposed in this paper can remove the invalid audible noise (AN) data of 1000 kV AC transmission lines without affecting the subsequent study of AN, we use various machine learning algorithms to predict the A weight sound level (Awsl) before and after the invalid data rejection, and the results show that the invalid data rejection has contributed to the improvement of the transmission line AN Awsl prediction accuracy.
Case Report: De novo KLHL24 Gene Pathogenic Variants in Chinese Twin Boys With Epidermolysis Bullosa Simplex
Authors: Xu Xiaojing , Zhao Juan , Wang Chao , Qu Xiaoxuan , Ran Menglong , Ye Fang , Shen Ming , Wang Kundi , Zhang Qi 
Published: November 2021

Objectives: The aim of this study was to determine the molecular etiology and clinical manifestations of a pair of Chinese twins affected with epidermolysis bullosa simplex. Pediatricians should pay attention to the early genetic diagnosis of this disease.Methods: Histopathological examination of HE-stained skin, electron microscopy of biopsied normal skin, and whole-exome sequencing was performed to assess pathogenicity and conservation of detected mutations. Two years later, the cutaneous and extracutaneous manifestations of the twins were comprehensively evaluated.Results:A de novo pathogenic variant c.2T&gt;C (p.M1T) in KLHL24 (NM_017,644) was identified in both twins. The characteristics of extensive skin defects on the extremities at birth and the tendency to lesson with increasing age were confirmed. No positive sensitive markers, such as B-type natriuretic peptide, cardiac troponin I, for cardiac dysfunction were detected.Conclusions: The de novo pathogenic variants c.2T&gt;C (p.M1T) in KLHL24 (NM_017,644) contributes to the development of epidermolysis bullosa. Genetic diagnosis at birth or early infancy can better predict the disease prognosis and guide the treatment.
The Combination of T Stage and the Number of Pathologic Lymph Nodes Provides Better Prognostic Discrimination in Early-Stage Cervical Cancer With Lymph Node Involvement
Authors: Bai Yongrui , Rong Ling , Hu Bin , Ma Xiumei , Wang Jiahui , Chen Haiyan 
Published: November 2021

ObjectiveStage I and II cervical cancer with pelvic and/or para-aortic lymph node (LN) metastases are upstaged to stage IIIC under the new FIGO 2018 staging system, and radical chemoradiotherapy was recommended. But heterogeneity in outcome existed in this group of patients. We conducted this retrospective analysis to evaluate the heterogeneity of these patients and tried to provide a more detailed classification to reflect the prognosis and guide the treatment. We also evaluated the efficacy and toxicity of surgery followed by sequential chemoradiotherapy in this cohort.MethodsEarly-stage cervical cancer with LN involvement that had radical hysterectomy followed by sequential chemoradiotherapy were retrospectively analyzed. Survival analyses were conducted to identify the prognostic factors.ResultsA total of 242 patients were included in the study; 64 (26.4%) patients had treatment failure, and 51 (21.1%) died. Pathology, T stage, the number of pathologic LN (pLN), and neoadjuvant chemotherapy or not were independent prognostic factors for disease-free survival and overall survival (OS). Patients with T1N &lt; 3 pLN had significantly better survival than T2N &lt; 3 pLN/T1-2 N≥ 3 pLN, with failure rates of 11.6% and 35.8% in each group; and 5 year OS was 92% and 62%, respectively (P = 0.000). About 1.5% of the patients discontinued radiotherapy, and 14.1% had G3-4 hematological toxic effects during radiotherapy; 1.7% developed G2-3 lower limb edema, and 2.9% developed severe urinary toxicity.ConclusionNodal involvement alone is inadequate as the sole pathologic factor to predict survival in early-stage cervical cancer. The combination of tumor and node subcategory provides better prognostic discrimination.
Continuous Renal Replacement Therapy for Two Neonates With Hyperammonemia
Authors: Markham Christopher , Williams Caroline , Miller Cory , Grange Dorothy K. , Davis T. Keefe , Remy Kenneth E. 
Published: November 2021

Objectives:This study aims to assess the feasibility of using hemofiltration for ammonia clearance in low body weight infants with an inborn error of metabolism.Design:A study of two cases.Setting:Quaternary pediatric hospital (Saint Louis Children's Hospital) NICU and PICU.Patients:Infants &lt;6 months of age with an ICD-9 diagnosis of 270.6 (hyperammonemia).Interventions:Continuous renal replacement therapy (CRRT).Measurements and Main Results:We measure serum ammonia levels over time and the rate of ammonia clearance over time. Continuous renal replacement therapy was more effective than scavenger therapy alone (Ammonul™) for rapid removal of ammonia in low weight infants (as low as 2.5 kg).Conclusions:Continuous renal replacement therapy is technically feasible in low weight infants with severe hyperammonemia secondary to an inborn error of metabolism.
The Mechanism Actions of Astragaloside IV Prevents the Progression of Hypertensive Heart Disease Based on Network Pharmacology and Experimental Pharmacology
Authors: Jing Haoran , Xie Rongsheng , Bai Yu , Duan Yuchen , Sun Chongyang , Wang Ye , Cao Rongyi , Ling Zaisheng , Qu Xiufen 
Published: November 2021

Astragaloside IV (AS-IV) has been used to treat cardiovascular disease. However, whether AS-IV exerts a protective effect against hypertensive heart disease has not been investigated. This study aimed to investigate the antihypertensive and cardioprotective effects of AS-IV on L-NAME-induced hypertensive rats via network pharmacology and experimental pharmacology. The network pharmacology and bioinformatics analyses were performed to obtain the potential targets of AS-IV and hypertensive heart disease. The rat hypertension model was established by administrated 50 mg/kg/day of L-NAME for 5 weeks. Meanwhile, hypertension rats were intragastrically administrated with vehicle or AS-IV or fosinopril for 5 weeks. Cardiovascular parameters (systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rates, and body weight), cardiac function parameters (LVEDd, LVEDs, and fractional shortening), cardiac marker enzymes (creatine kinase, CK-MB, and lactate dehydrogenase), cardiac hypertrophy markers (atrial natriuretic peptide and brain natriuretic peptide), endothelial function biomarkers (nitric oxide and eNOS), inflammation biomarkers (IL-6 and TNF-α) and oxidative stress biomarkers (SOD, MDA, and GSH) were measured and cardiac tissue histology performed. Network pharmacological analysis screened the top 20 key genes in the treatment of hypertensive heart disease treated with AS-IV. Besides, AS-IV exerted a beneficial effect on cardiovascular and cardiac function parameters. Moreover, AS-IV alleviated cardiac hypertrophy via down-regulating the expression of ANP and BNP and improved histopathology changes of cardiac tissue. AS-IV improved endothelial function via the up-regulation of eNOS expression, alleviated oxidative stress via increasing antioxidant enzymes activities, and inhibited cardiac inflammation via down-regulating IL-6 and TNF-α expression. Our findings suggested that AS-IV is a potential therapeutic drug to improve L-NAME-induced hypertensive heart disease partly mediated via modulation of eNOS and oxidative stress.