bluuebunny/crossref_metadata_2025_split huggingface dataset:
Day-to-day dynamics of fetal heart rate variability to detect chorioamnionitis in preterm premature rupture of membranes
Authors: Taoum Aline , Carrault Guy , Tesson Caroline , Esvan Maxime , Laviolle Bruno , Lassel Linda 
Published: January 2025

Background
Chorioamnionitis is recognized as a major consequence of preterm premature rupture of membranes (PPROM), and a frequent cause of neonatal morbidity and mortality. The association between fetal heart rate (FHR) and chorioamnionitis remains unclear.

Objectives
The aim of this study was to evaluate the dynamics of FHR in a PPROM population at the approach of delivery according to the presence or absence of chorioamnionitis.

Materials & methods
120 pregnant women with PPROM between 26 and 34 weeks’ gestation were enrolled in this multicenter prospective unblinded study. All participants were fully informed of the study’s objectives. 39 of the 120 patients were included in the analysis of FHR recordings. The analysis consisted of extracting features from computerized FHR analysis (cFHR) and fetal heart rate variability analysis (FHRV) in the temporal, frequency and nonlinear domains. Then, each set of features was analyzed separately using the multiple factor analysis, where three groups were defined as the feature set for days 0, -1 and -2 prior to birth. The distances between the global projection and the projections for each day were computed and used in the ROC analysis to distinguish chorioamnionitis from non-chorioamnionitis group.

Results
The results showed that there were significant differences in certain features between populations with and without chorioamnionitis. The distinction between the two populations reached an area under the curve (AUC) of only 37% [34–40] for cFHR features and 63% [59–66] for time-domain FHRV features when comparing all stages of chorioamnionitis to non-chorioamnionitis subjects. When only stage 3 chorioamnionitis was compared to non-chorioamnionitis patients, the AUC reached 90% [88–93] for nonlinear-domain and 84% [82–87] for time-domain FHRV features, whereas it was limited to 71% [68–74] using cFHR features.

Conclusion
The present study suggests that the HRV features are more reliable for diagnosing chorioamnionitis than cFHR, and that the assessment of features dynamics over several days is an interesting tool for detecting chorioamnionitis. Further study should be carried out on a larger sample to confirm these findings, improve the diagnostic performance of chorioamnionitis and help clinicians decide on delivery criteria.
Virological outcomes of antiretroviral therapy and its determinants among HIV patients in Ethiopia: Implications for achieving the 95–95–95 target
Authors: Kitaw Tegene Atamenta , Haile Ribka Nigatu 
Published: January 2025

Background
Despite significant advancements in HIV treatment, virological outcomes remain a critical issue. Ethiopia did not meet the 90:90:90 targets set for 2020, which aimed for 90% of people on antiretroviral therapy to achieve viral suppression. As the country shifts its focus toward the 95:95:95 targets for 2030—seeking to achieve 95% viral suppression among those on ART—it is crucial to deepen our understanding of viral suppression and the factors that influence it.

Methods
Virological suppression was examined among 410 HIV-positive individuals on ART using the EPHIA survey. The survey employed a two-stage, stratified sampling design across urban areas in nine regions and two city administrations. Data analysis was conducted with STATA version 18, and multicollinearity was assessed using variance inflation factors. A logistic regression model identified significant determinants of viral suppression, with variables having a p-value of ≤0.05 considered statistically significant in the multivariable analysis.

Results
The findings revealed that 364 participants (88.78%) achieved viral suppression. Key determinants of virological outcomes included a higher wealth level (AOR = 2.67, 95% CI: 1.15–6.22), the presence of active TB (AOR = 0.27, 95% CI: 0.14–0.57), hepatitis B virus (AOR = 0.20, 95% CI: 0.10–0.31), and the utilization of HIV support group care (AOR = 3.14, 95% CI: 1.35–6.30).

Conclusion
Viral suppression among HIV patients is 88.78%, which even falls short of the WHO’s 90% target for 2020, indicating the substantial work required to achieve 95% by 2030. To improve virological outcomes, it is crucial to increase support for low-income patients, enhance management of co-infections like TB and hepatitis B, and expand access to HIV support groups for better adherence and care.
Impact of posterior septectomy on olfaction in endoscopic endonasal transsphenoidal surgery
Authors: Lee Jae Yoon , Park Jae Sung , Jeun Sin Soo , Kim Sung Won , Kim Do Hyun , Kim Soo Whan 
Published: January 2025

Background
Endoscopic endonasal transsphenoidal surgery is widely used to resect pituitary adenomas, yet its impact on olfactory function after resection of the posterosuperior nasal septum remains a concern. To optimize surgical techniques to preserve olfactory function, it is essential to understand the relationship between the extent of septal resection and olfactory outcomes.

Methods
This retrospective study analyzed 295 patients who underwent pituitary adenoma surgery. The extent of nasal septum resection was quantified and its impact on olfactory function was assessed using the Cross-Cultural Smell Identification Test (CCSIT), Sino-Nasal Outcome Test-22 (SNOT-22), and a Visual Analog Scale (VAS) for olfactory loss. Preoperative and 6-month postoperative scores were compared to evaluate changes in olfactory function.

Results
There was a significant correlation between larger septal resections and greater reductions in CCSIT scores, indicating a decline in olfactory function. Furthermore, patients with more extensive septal resections reported increased discomfort and olfactory loss, as evidenced by higher SNOT-22 and VAS scores. These findings highlight the importance of the nasal septum in maintaining laminar airflow and its role in olfactory function.

Conclusion
Study underscores the adverse effects of extensive posterior septectomy on olfactory outcomes. Minimizing the extent of septal resection may help preserve olfactory function, suggesting a need for surgical strategies that maintain septum integrity to reduce the risk of postoperative olfactory impairment.
Reflections on Plutarch’s Lives of Aemilius Paullus and Timoleon
Authors: Sansone David 
Published: January 2025

Plutarch opens the Lives of Aemilius Paullus and Timoleon with a metaphor comparing his writing of biographies to a mirror in which he contemplates his own life. This is the only time in the Lives he uses this metaphor. The paper seeks to relate this image to the fact that, apparently for the first time, Plutarch has placed the Life of his Greek hero after that of the Roman. It is suggested that this reversal of his usual practice, combined with several subtle indications throughout the pair of Lives, indicates Plutarch’s greater sympathy for, and even identification with, Timoleon, despite his frequent efforts to appear to be even-handed in his treatment of the two men.
Konrad Lorenz a klasická etologie ve východním bloku
Authors: Stella Marco 
Published: January 2025

From 1963 to 1989, the conceptual framework of Konrad Lorenz, the founder of ethology as a scientific field, had been criticized for ideological reasons in Eastern Socialist block countries. The ideas of Lorenz that follow both the theories of earlier German biologists from the break of 19th and 20th centuries [von Uexküll, Heinroth] and classic Darwinism, were directly at odds with the Marxist-Leninist concept of human nature as well as the official materialist-dialectic doctrine in science. The entirety of Lorenz´s reflections aboutmostly inherent origin of human behaviour is incompatible with the Marxist-Leninist idea of a human that is completely, or to a large extent, modifiable by culture. Attitudes towards research of animal behaviour varied in each of the socialist countries. Following the Second World War, the USSR continued with the tradition of comparative psychology and the reflex theory of I. P. Pavlov, which were more compatible with the Marxist-Leninist ideology. However, research of animals in their natural environment (e.g. that of Panov and Kushinskij) already existed in the Soviet Union, although Lorenz´s work had been largely ignored. Nevertheless, some of Lorenz´s work was published in the USSR, which was not the case in Czechoslovakia and other countries of the East block. This might have been partly because Lorenz had established contacts among some scientists in the USSR gained during his wartime captivity between 1944-1948. While ethology and, in particular, the appication of its methods to human behaviour and entire human societies, were being rejected by Marxist philosophers, there was still a relatively small number of professionals who knew and applied the knowledge of ethology in socialist Czechoslovakia. Specifically, Zdeněk Veselovský and Jaroslav Madlafousek, who, among others, had crucially introduced the teaching of ethology at universities spreading its knowledge among the wider public (e.g. the ´popular science´ works of Zdeněk Veselovský). Ethology in general, and especial!y human ethology, a very young scientific branch, did not have much of a tradition in socialist Czechoslovakia (where it had been rather frowned upon) or later in the Czech Republic. The result is that present interest in the field is considerably lower than, for instance, in Western European countries. In addition, it proves to be quite difficult (not just in the Czech Republic, but also worldwide) to establish the concepts of human ethology in human and social sciences. This is often due to mutual misunderstandings among scientists of the biological and socio-human disciplines.
Moderné biotechnológie v školskom vzdelávaní z pohľadu zahraničných výskumných šetrení
Authors: Horniaková Michaela 
Published: January 2025

Predložená prehľadová štúdia sa zaoberá zahraničnými výskumami v oblasti vzdelávania, ktoré skúmajú znalosti vo väzbe na prekoncepty a miskoncepty respondentov o moderných biotechnológiách. Cieľom štúdie je teda poskytnúť komplexný prehľad existujúcich zahraničných výskumov týkajúcich sa primárne poznatkov a predovšetkým prekonceptov a miskonceptov v danej oblasti. Štúdia sa zameriava na analýzu zahraničných výskumov od roku 2000 po rok 2023. Výskumy boli vyhľadávané v databázach Web of Science a Scopus na základe kľúčových pojmov/slov. Analyzuje v relevantných výskumoch sledované ciele, využité metódy, výsledky výskumov a ich odporúčania pre budúcnosť. Z výsledkov zahraničných výskumov je zrejmé, že žiaci majú minimálne znalosti o moderných biotechnológiách, navyše im chýba konceptové porozumenie biotechnológií ako celku. V závere sa štúdia sústreďuje na zhodnotenie práce s prekonceptami žiakov v súvislosťami s výsledkovou časťou prehľadovej štúdie. Poukazuje na teóriu, ktorá sa prekonceptami žiakov priamo zaoberá a v nadväznosti na ňu predkladá možný prístup, ktorý je využiteľný pri práci s prekonceptami a k náprave miskonceptov žiakov práve v prírodovednom vzdelávaní. Táto prehľadová štúdia môže slúžiť ako základ pre ďalšie výskumy alebo vývoj pedagogických stratégií zameraných na zlepšenie vyučovania biotechnológií a pochopenie prekonceptov a miskonceptov nie len u žiakov.
Dekolonizacja edukacji a aspiracje w społeczności romskiej w Polsce
Authors: Styrkacz Sonia 
Published: January 2025

Celem niniejszego artykułu jest zbadanie wpływu dekolonizacji edukacji na formowanie aspiracji edukacyjnych i życiowych wśród Romów, z uwzględnieniem specyfiki aktywizmu romskiego. W kontekście teorii kapitału społecznego Bourdieu, teorii samookreślenia Deci i Ryana, analizuję, jak dekolonialne podejście do edukacji, oparte na szacunku dla różnorodności kulturowej i językowej, może wspierać rozwój aspiracji w grupach marginalizowanych. Artykuł pokazuje, że przekształcenie edukacji w duchu dekolonizacji wymaga nie tylko zmian w programach nauczania i metodach dydaktycznych, ale również krytycznej rewizji dominujących narracji i praktyk edukacyjnych, by lepiej odzwierciedlały one złożoność i różnorodność społeczną. Artykuł koncentruje się na sytuacji Romów w Polsce, którzy zmagają się z wyzwaniami wynikającymi z marginalizacji i dyskryminacji w systemie edukacyjnym. Analiza aktywizmu romskiego ukazuje, jak działania kolektywne mogą wzmacniać jednostkowe aspiracje, a indywidualne dążenia przyczyniać się do realizacji celów grupowych. Ruch romski, poprzez budowanie kapitału społecznego i promowanie inkluzywności, odgrywa kluczową rolę w zmianie narracji dotyczącej Romów i w dążeniu do równości edukacyjnej. Artykuł podkreśla, że realizacja aspiracji edukacyjnych i życiowych wśród Romów wymaga kompleksowego podejścia, które uwzględnia zarówno strukturalne bariery i ograniczenia kapitału społecznego, jak i potrzebę wsparcia w realizacji podstawowych potrzeb psychologicznych: autonomii, kompetencji i przynależności. Dekolonizacja edukacji poprzez uwzględnienie perspektyw, wartości i doświadczeń Romów stanowi kluczowy krok ku bardziej sprawiedliwemu i inkluzywnemu systemowi edukacyjnemu.
Axodendritic targeting of TAU and MAP2 and microtubule polarization in iPSC-derived versus SH-SY5Y-derived human neurons
Authors: Breuer Helen , Bell-Simons Michael , Zempel Hans 
Published: January 2025

Abstract
Cell polarity is crucial in neurons, characterized by distinct axonal and dendritic structures. Neurons generally have one long axon and multiple shorter dendrites, marked by specific microtubule (MT)-associated proteins, e.g., MAP2 for dendrites and TAU for axons, while the scaffolding proteins AnkG and TRIM46 mark the axon-initial-segment. In tauopathies, such as Alzheimer’s disease (AD), TAU sorting, and neuronal polarity are disrupted, leading to MT loss. However, modeling and studying MTs in human neuronal cells relevant to the study of AD and TAU-related neurodegenerative diseases (NDD) is challenging. To study MT dynamics in human neurons, we compared two cell culture systems: SH-SY5Y-derived neurons (SHN) and induced pluripotent stem cell-derived neurons (iN). Using immunostaining and EB3-tdTomato time-lapse imaging, we found AnkG absent in SHN but present in iN, while TRIM46 was present in both. TAU and MAP2 showed axonal and dendritic enrichment, respectively, similar to mouse primary neurons. Both neuron types exhibited polarized MT structures, with unidirectional MTs in axons and bidirectional MTs in dendrites. Polymerization speeds were similar; however, iNs had more retrograde MT growth events, while SHN showed a higher overall number of growth events. Thus, SHN and iN are both suitable for studying neuronal cell polarity, with SHN being particularly suitable if the focus is not the AIS.
The effect of a provisional diagnosis on intern diagnostic reasoning: a mixed methods study
Authors: Clary Cody , Cohen Adam , Kumar Shelley , Sur Moushumi , Rissmiller Brian , Singhal Geeta , Thammasitboon Satid 
Published: January 2025

Abstract

Objectives
Competency in diagnostic reasoning is integral to medical training and patient safety. Situativity theory highlights the importance of contextual factors on learning and performance, such as being informed of a provisional diagnosis prior to a patient encounter. This study aims to determine how being informed of a provisional diagnosis affects an intern’s approach to diagnostic reasoning.

Methods
This mixed methods study was conducted in a real-time workplace learning environment at a large teaching hospital. Interns were randomized to the Chief Complaint (CC) only or chief complaint with Provisional Diagnosis (PD) group. One blinded researcher assessed intern diagnostic reasoning using a validated tool. Mean group scores were compared using the two-sample t-test. The researcher was unblinded for think aloud interviews analyzed via thematic analysis.

Results
There was no difference in performance between the CC and PD groups (mean ± SD): 47.8 ± 8.1 vs. 43.9 ± 10.9, p=0.24. Thematic analysis identified that interns aware of the provisional diagnosis 1) invested less effort in diagnostic reasoning, 2) formulated a differential through a narrowly focused frame, 3) accepted a provisional diagnosis as definitive, and 4) sought to confirm rather than refute the provisional diagnosis.

Conclusions
Our discordant results highlight the complex interplay between a provisional diagnosis and diagnostic reasoning performance in early learners. Though an accurate provisional diagnosis may enhance diagnostic reasoning outcomes, our qualitative results suggest that it may pose certain risks to the diagnostic reasoning process. Metacognitive strategies may be a ripe field for exploration to optimize this complex interplay.
Preparation of natural raw rubber and silica/NR composites with low generation heat through aqueous silane flocculation
Authors: Diao Pengfei , Xiao Yao , Gong Zheng , Yang Shenglong , Wang He , Wang Chuansheng , Bian Huiguang 
Published: January 2025

Abstract
An aqueous aminosilane oligomer, Crosile® 8150 (hereinafter referred to as 8150) was introduced to flocculate natural rubber latex, realizing the preparation of natural raw rubber and natural rubber composites. Compared with smoked rubber, the natural raw rubber flocculated with 2, 4, and 6 phr 8150 exhibited lower glass transition temperatures, enhancing the flexibility of the molecular chain, improving the plasticity retention rates by 18.32%, 1.75%, and 22.18%, respectively, and increasing the resistance to thermo-oxidative aging. The silica/natural rubber composites prepared from natural dry rubber prepared by 8150 flocculation had superior rolling resistance properties compared to smoked rubber. The application of 8150 in the preparation of natural rubber composites eliminates the acid and salt flocculants. This reduction in the generation of waste gases and equipment corrosion during the flocculation process enhances the preparation quality of natural dry rubber. The research provides significant theoretical and practical implications for realizing high-quality natural dry rubber.
Multi-scenario territorial spatial simulation and dynamic changes: A case study of Jilin Province in China from 1985 to 2030
Authors: Shi Dan , Liu Xuan , Jin Jing , Wan Daiji , Chen Baolong , Liu Jiping 
Published: January 2025

Abstract
Territorial spatial resource changes play an irreplaceable role in the human development process, providing the necessary dependency conditions and ecosystem services for human production and life. This article takes Jilin Province, China, as the study area, analyzes the characteristics of the dynamic evolution of territorial spatial in Jilin Province from 1985 to 2020, and simulates the spatial and temporal changes of land space in Jilin Province under three different scenarios in 2030. The results show that: (1) From 1985 to 2020, the productive space (PS) and living space (LS) show a gradual increase trend; the ecological space (ES) shows a decrease trend. The LS is scattered except in the Changbai Mountain area; the PS is mainly concentrated in the west and expands year by year; the ES is mainly in the east, and its scope shrinks year by year. (2) From 1985 to 2020, the center of gravity of PS changes more slowly and moves northward as a whole. The change of the center of gravity of LS is mainly concentrated in Changchun, and its center of gravity is shifting southward. The center of gravity of ES moves more sharply, first to the northwest and then gradually to the southeast. (3) Under the natural development scenario in 2030, the territorial spatial area fluctuation is mainly in the north of Songyuan City, central Jilin City, and the north of Changchun City. Under the ecological protection scenario, the area dynamics of Changchun City, Songyuan City, and the northwestern part of Baicheng City change significantly. Under the economic development scenario, the hotspot areas of spatial area change are mainly in the western part of Jilin Province.
Apitherapy for diabetes mellitus: mechanisms and clinical implications
Authors: Jagua-Gualdrón Andrés , García-Reyes Nicolai Andrés , Fernández-Bernal Roger Edwin 
Published: January 2025

Abstract

Introduction
Diabetes mellitus is a complex disease in terms of its causes and pathophysiological processes, it produces a significant impact on health and leads to complications that are difficult to manage.

Content
This review summarizes and analyzes recent advances in the understanding of the mechanisms of diabetes mellitus and how apitherapy affects them. Also present the available clinical evidence on its application.

Summary
Apitherapy (complementary-integral use of beehive products) is a potentially useful therapeutic system with a significant level of evidence. This review shows and analyzes the preclinical and clinical evidence on the use of apitherapy in diabetes mellitus.

Outlook
Apitherapy shows significant effects on epigenetics, chronic inflammation, oxidative stress, metabolic control, dysbiosis, premature cell death and tissue remodeling. Clinical evidence shows an impact on these mechanisms. Apitherapy is a very useful complementary medicine in the treatment of diabetes mellitus.
Abrocoma bennettii (Rodentia: Abrocomidae): new records and range extension of its altitudinal distribution
Authors: Riveros-Riffo Edvin , González-Pinilla Francisco J. , Palma R. Eduardo 
Published: January 2025

Abstract
Bennett’s chinchilla rat (Abrocoma bennettii) is an hystricomorph rodent endemic to Chile inhabiting semi-arid and meditarranean regions below 2,000 m above sea level, from northern and central Chile. Using various lines of evidence, including camera traps, skulls, middens, and DNA, this study reports two new records of A. bennettii discovered during the course of a baseline fauna survey. These new records expand their current altitudinal limit up to 3,500 m above sea level and reveal an unprecedented potential sympatry with Abrocoma cinerea in the Andes of the Atacama Region, highlighting the ecological versatility of this common yet elusive rodent.