bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of cure mechanism inside die for a part manufacturing during large‐scale pultrusion
Authors: Mukherji Arindam , Tarapore Nozer , Njuguna James 
Published: December 2021

AbstractThe cure kinetics of resin, heat capacity, and thermal conductivity of reinforcing materials of uncured mass dictate the ultimate curing of reinforced thermosets manufactured component. In this study, the degree of conversion from heat capacity by “Lumry and Eyring Model” and order of reaction by multi‐regression technique using “Borchardt and Daniels Model” are calculated in finding cure kinetics () of the resin. Experimental results from differential scanning calorimetry, thermogravimetry (TGA), and rheological measurements were used to determine thermal conductivity, heat capacity, and rheological parameters of the resin through several model fitting. The calculated thermal conductivity of uncured composite from ration of (length vs. contact area) and thermal resistivity extracted from TGA data was fitted into a specific mathematical model, which predicts the thermal behavior of heated prepreg during pultrusion operation. These parameters used in a separate mathematical partial differential equation‐based model equation to predict the change in temperature and resin conversion along axial distance and radial thickness. The influence of operating conditions, such as rate of heating (early and late heating) and fiber volume fraction while curing inside die were calculated and validated with experimental results. This study evaluates the extent of heat transfer and degree of conversion inside pultrusion die during scale up steady state process. It is observed that the paradigm of influencing parameters like pulling speed, die radial thickness and heater engagement (early and late heating) on heat flow from die wall to core (i.e., thickness of the part being pulled) follows the data captured experimentally.
Interlaminar fracture and crack‐healing capability of carbon fiber/epoxy composites toughened with 3D‐printed poly‐ε‐caprolactone grid structures
Authors: Beylergil Bertan 
Published: December 2021

AbstractIn this study, carbon fiber (CF)/epoxy (EP) composites are toughened with 3D‐printed poly‐ε‐caprolactone (PCL) grid structures which are produced by fused deposition modeling at three different areal weight densities and place between dry plain‐weave carbon fabrics prior to resin infusion. Three‐point bending, Mode‐I fracture toughness, interlaminar shear strength (ILSS), and Charpy impact tests are carried out on the prepared composite specimens. The results show that the PCL interlayers can enhance Mode‐I fracture toughness up to seven times (693%). The main toughening mechanism is the crack bridging due to the formation of PCL fibrils. It is shown that there is a quadratic relationship between the amount of PCL and Mode‐I fracture toughness improvement. The thermal healing efficiencies (η) for the first and second healing of PCL reinforced composites are determined as 44.1% and 28.2%, respectively. DMA results indicates that the tanδ values are increased almost 10 times with the addition of PCL interlayers. The flexural properties are decreased due to the reduced fiber volume fraction, higher void content, and plasticization effect of PCL interlayers.
Bio‐cleaned lignin‐based carbon fiber and its application in adsorptive water treatment
Authors: Chen Jiawei , Ghosh Tanushree , Ayranci Cagri , Tang Tian 
Published: December 2021

AbstractAlthough an agricultural byproduct, lignin can be a felicitous choice serving as a carbon fiber precursor upon bio‐cleaning with Pseudomonas fluorescence. In this study, carbon fiber produced from electrospun bio‐cleaned lignin (Bio‐KLB) was demonstrated to be a novel efficient adsorbent for methylene blue in wastewater treatment. Bio‐cleaning effectively changed lignin from un‐electrospinnable to easily‐electrospinnable by removing impurities. Bio‐KLB carbon fiber mats showed average fiber diameter of 278.95 ± 49.89 nm, and randomly dispersed fiber mats showed average elastic modulus of 1532.87 ± 439.63 MPa and tensile strength of 16.72 ± 5.21 MPa. Adsorption of methylene blue on Bio‐KLB carbon fibers was analyzed at pH = 9, where optimal adsorption and decent reusability were observed. Kinetic adsorption was fitted well with pseudo‐first‐order model while adsorption isotherms were fitted to both Langmuir and Freundlich models. The highest adsorption capacity was 548.65 mg/g based on Langmuir model. The results provide clear evidence that electrospun bio‐cleaned lignin‐based carbon fibers can be a strong alternative material for dye treatment.
Fabrication of microcrystalline cellulose/zinc oxide hybrid composite by hydrothermal synthesis and its application in rubber compounding
Authors: Boopasiri Supparoek , Sae‐Oui Pongdhorn , Siriwong Chomsri 
Published: December 2021

AbstractWith great concern of environmental threats, attempts have been made to reduce the consumption of zinc oxide (ZnO) in rubber products. This research aims at fabricating a new type of ZnO by depositing ZnO on microcrystalline cellulose (MCC) surface using an ultrasonic‐assisted hydrothermal process. The concentration ratio of Zn(NO3)2 to NaOH is varied from 1:1 to 1:4. The obtained products, namely MCC‐ZnO, are characterized by various techniques such as field emission scanning electron microscope, Fourier transform infrared spectroscopy, X‐ray diffraction, Brunauer–Emmett–Teller, and Thermogravimetric analysis. Results show that the amount of deposited ZnO and the specific surface area of MCC‐ZnO increase continuously with increasing NaOH concentration. The MCC‐ZnO (1:3) containing approximately 55.6 wt% of deposited ZnO is selected for investigating the curing efficiency in natural rubber (NR) and compared with the commercial ZnO (C‐ZnO). Obviously, the state of cure progressively increases with increasing either MCC‐ZnO or C‐ZnO content. At the same content, MCC‐ZnO exhibits a significantly higher crosslink density than C‐ZnO leading to the superior elasticity and mechanical properties. This could be explained by the greater specific surface area and, thus, the higher reactivity of MCC‐ZnO. Clearly, a considerably lower quantity of MCC‐ZnO is required to attain a similar level of crosslink density or mechanical properties as compared to C‐ZnO.
Information behavior and practices research informing information systems design
Authors: Huvila Isto , Enwald Heidi , Eriksson‐Backa Kristina , Liu Ying‐Hsang , Hirvonen Noora 
Published: December 2021

AbstractInformation behavior and practices (IBP) research has been repeatedly criticized for having little impact on information systems development (ISD). Claiming that there is a complete disconnect would be an exaggeration but it is apparent that it is not always easy to translate findings of IBP research to workable design recommendations. Based on a reading of earlier literature and a closer investigation of three illustrative example contexts, this article underlines that the value of IBP research for ISD lies in its capability to inform ISD of the variety of ways people deal with information beyond individual systems, their own wants and designers' assumptions. Moreover, it highlights that the implications of information systems go beyond their primary users. Instead of overemphasizing the contextuality of findings, a part of IBP research would benefit from an increased focus on explicating its epistemological extents and limits and identifying, which findings are transferable, what distinguishes specific contexts, what are their defining constraints and priorities, and what aspects of their uniqueness are assumptions and simple clichés.
Synthesis and Processing by Design of High‐Nickel Cathode Materials
Authors: Wang Feng , Bai Jianming 
Published: December 2021

AbstractInvited for this month's cover picture is the group of Feng Wang and Jianming Bai at Brookhaven National Laboratory. The cover picture shows “watching” the formation of Li(NiMnCo)O2 (NMC) particles and their evolving structure and morphology in real time, providing guidance to rational design of synthesis/processing in making high‐performance NMC cathodes for batteries powering electric vehicles. Read the full text of the Minireview at 10.1002/batt.202100174.
Myasthenia gravis: The pharmacological basis of traditional Chinese medicine for its clinical application
Authors: Xiaoyue Shen , Yanbin Li 
Published: December 2021

AbstractWe aimed to investigate the target and signal pathway of Smilacis Glabrae Rhixoma (SGR) in the treatment of myasthenia gravis (MG) based on network pharmacology, and to explore its potential molecular mechanism. The main active components of SGR were searched in the pharmacology database of traditional Chinese medicine systems, and analysis platform. The related targets of SGR were obtained by Genecards, connective tissue disease, therapeutic target database, Drugbank, and Online Mendelian Inheritance in Man database. Moreover, the target information was corrected through UniProtKB and also, this data integrated to draw the “Ingredients‐targets” network of SGR. Protein interaction analysis was performed in data platform, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways as well as enrichment analysis on disease‐drug target was carried out through metascape online platform. A total of 15 active components were collected from SGR, which correspond to 159 targets; There were 1758 MG‐related targets; there are 81 targets related to both drug components and diseases, including 12 key targets. In GO bioaccumulation analysis, 1933 GO items were gathered, which were mainly related to the metabolism of active oxygen species and the active factors of postsynaptic neurotransmitter receptor. According to KEGG analysis, SGR may play a role in the treatment of MG through phosphatidylinositol‐3‐kinase–protein kinase B signaling pathway, T‐cell receptor, cAMP, tumor necrosis factor (TNF), and interleukin‐17 (IL‐17) signaling pathway, Th17 cell differentiation, endocrine resistance, hepatitis, and some cancer pathways. This study shows that SGR mainly treat myasthenia gravis through the regulation of TNF, MAPK1, JUN, TP53 and other targets, T‐cell receptor, TNF, and IL‐17 signaling pathway, Th17 cell differentiation and other pathways, which reflects the characteristics of multicomponent, multitarget, and multichannel of traditional Chinese medicine, and providing a certain pharmacological basis for the follow‐up study.
Novel anion exchange membrane chromatography method for the separation of empty and full adeno‐associated virus
Authors: Hejmowski Adam L , Boenning Kurt , Huato Julio , Kavara Aydin , Schofield Mark 
Published: December 2021

AbstractA challenge in the production of recombinant Adeno‐Associated Virus (AAV) for gene therapies is the presence of capsids that lack the required gene of interest. The impact of these empty vectors in therapies is not fully understood, however the ability to control the ratio of empty to full particles, which contain the genetic payload, is a necessary step in the purification of these viruses. In this study, a novel anion exchange chromatography elution method for enrichment of full AAV particles is demonstrated. A step gradient with small conductivity increases of around 1 mS cm–1 provides more efficient separation of empty and full AAV serotype 5 across membrane media as compared to conventional linear gradient method. The use of this approach in optimizing a simpler method for manufacturing processes and scalability to a larger chromatographic volume is explored. With this approach, the authors achieved greater than 4‐fold enrichment of full capsids, to give a total of ≈50%–60% full capsids, using a 25 mM Bis‐Tris Propane pH 9.0 buffer system with NaCl as the eluting salt. Results suggest that this elution method can be implemented into a scalable process and can provide insight into development of elution methods for other AAV serotypes.
Simultaneously screening multiple UGT1A1 inhibitors from Polygonum multiflorum root using ultrafiltration LC–MS
Authors: Jiang Yan , Zhang Cai , Zheng Xian , Zhao Zhen , Li Hui‐Jun 
Published: December 2021

AbstractLiver injury induced by Polygonum multiflorum root (PMR) is an immediate issue requiring global attention. UDP‐glucuronosyltransferase 1A1 (UGT1A1) inhibitors are suspected to additively contribute to the hepatotoxicity of PMR. This study was deliberately designed to simultaneously screen UGT1A1 inhibitors from PMR, and their co‐contribution to hepatotoxicity was determined. Using ultrafiltration coupled to LC–MS method, four compounds, namely cis‐2,3,5,4′‐tetrahydroxystilbene‐2‐O‐β‐glucoside, trans‐2,3,5,4′‐tetrahydroxystilbene‐2‐O‐β‐d‐glucoside, emodin‐8‐O‐β‐d‐glucoside, and emodin, were screened, exhibiting the in vitro inhibitory activities against UGT1A1 with IC50 values of 76.23, 18.70, 62.18, and 34.02 μM, respectively. The varying activities of the screened UGT1A1 inhibitors were demonstrated by performing a molecular docking simulation. Finally, zebrafish larvae and mice assays demonstrated that the UGT1A1 inhibitors co‐contributed to the hepatotoxicity of PMR. These findings are conducive to understand the role of UGT1A1 inhibitors in PMR‐induced hepatotoxicity.
Differential mechanisms of posterior cingulate cortex downregulation and symptom decreases in posttraumatic stress disorder and healthy individuals using real‐time fMRI neurofeedback
Authors: Nicholson Andrew A. , Rabellino Daniela , Densmore Maria , Frewen Paul A. , Steyrl David , Scharnowski Frank , Théberge Jean , Neufeld Richard W.J. , Schmahl Christian , Jetly Rakesh , Lanius Ruth A. 
Published: December 2021

AbstractBackgroundIntrinsic connectivity networks, including the default mode network (DMN), are frequently disrupted in individuals with posttraumatic stress disorder (PTSD). The posterior cingulate cortex (PCC) is the main hub of the posterior DMN, where the therapeutic regulation of this region with real‐time fMRI neurofeedback (NFB) has yet to be explored.MethodsWe investigated PCC downregulation while processing trauma/stressful words over 3 NFB training runs and a transfer run without NFB (total n = 29, PTSD n = 14, healthy controls n = 15). We also examined the predictive accuracy of machine learning models in classifying PTSD versus healthy controls during NFB training.ResultsBoth the PTSD and healthy control groups demonstrated reduced reliving symptoms in response to trauma/stressful stimuli, where the PTSD group additionally showed reduced symptoms of distress. We found that both groups were able to downregulate the PCC with similar success over NFB training and in the transfer run, although downregulation was associated with unique within‐group decreases in activation within the bilateral dmPFC, bilateral postcentral gyrus, right amygdala/hippocampus, cingulate cortex, and bilateral temporal pole/gyri. By contrast, downregulation was associated with increased activation in the right dlPFC among healthy controls as compared to PTSD. During PCC downregulation, right dlPFC activation was negatively correlated to PTSD symptom severity scores and difficulties in emotion regulation. Finally, machine learning algorithms were able to classify PTSD versus healthy participants based on brain activation during NFB training with 80% accuracy.ConclusionsThis is the first study to investigate PCC downregulation with real‐time fMRI NFB in both PTSD and healthy controls. Our results reveal acute decreases in symptoms over training and provide converging evidence for EEG‐NFB targeting brain networks linked to the PCC.
What if the future of HER2‐positive breast cancer patients was written in miRNAs? An exploratory analysis from NeoALTTO study
Authors: Pizzamiglio Sara , Cosentino Giulia , Ciniselli Chiara M. , De Cecco Loris , Cataldo Alessandra , Plantamura Ilaria , Triulzi Tiziana , El‐abed Sarra , Wang Yingbo , Bajji Mohammed , Nuciforo Paolo , Huober Jens , Ellard Susan L. , Rimm David L. , Gombos Andrea , Daidone Maria Grazia , Verderio Paolo , Tagliabue Elda , Di Cosimo Serena , Iorio Marilena V. 
Published: December 2021

AbstractBackgroundNeoadjuvant therapy with dual HER2 blockade improved pathological complete response (pCR) rate in HER2‐positive breast cancer patients. Nevertheless, it would be desirable to identify patients exquisitely responsive to single agent trastuzumab to minimize or avoid overtreatment. Herein, we evaluated the predictive and prognostic value of basal primary tumor miRNA expression profile within the trastuzumab arm of NeoALTTO study (ClinicalTrials.gov Identifier:NCT00553358).MethodsRNA samples from baseline biopsies were randomized into training (n= 45) and testing (n= 47) sets. After normalization, miRNAs associated with Event‐free survival (EFS) and pCR were identified by univariate analysis. Multivariate models were implemented to generate specific signatures which were first confirmed, and then analyzed together with other clinical and pathological variables.ResultsWe identified a prognostic signature includinghsa‐miR‐153‐3p(HR 1.831, 95% CI: 1.34–2.50) andhsa‐miR‐219a‐5p(HR 0.629, 95% CI: 0.50–0.78). For two additional miRNAs (miR‐215‐5pandmiR‐30c‐2‐3p), we found a statistically significant interaction term with pCR (p.interaction: 0.017 and 0.038, respectively). Besides, a two‐miRNA signature was predictive of pCR (hsa‐miR‐31‐3p, OR 0.70, 95% CI: 0.53–0.92, andhsa‐miR‐382‐3p, OR: 1.39, 95% CI: 1.01–1.91). Notably, the performance of this predictive miRNA signature resembled that of the genomic classifiers PAM50 and TRAR, and did not improve when the extended models were fitted.ConclusionAnalyses of primary tumor tissue miRNAs hold the potential of a parsimonious tool to identify patients with differential clinical outcomes after trastuzumab based neoadjuvant therapy.
Assimilating problematic life script themes in clinical supervision: The case of Sarah
Authors: van Rijn Biljana , Agar Jamie , Sills Charlotte , Stiles William B. 
Published: December 2021

AbstractObjectivesLife script is a transactional analysis concept describing a pattern of human experience, interaction and meaning making developed in childhood that can be activated in adulthood, sometimes creating problems. Problematic life script themes can impact a therapist's experience and interaction during clinical work and interfere with therapeutic effectiveness. This study used the comparative script system theory to assess how one therapist's problematic life script themes were manifested in supervision, how they were addressed, and whether addressing them advanced assimilation of the problematic material.MethodSeven consecutive monthly supervision sessions with a 50‐year‐old, highly experienced female therapist in private practice (pseudonym ‘Sarah’) were analysed by a team of five investigators using a qualitative theory‐building approach. The assimilation of problematic experiences sequence (APES) was used to track changes in Sarah's life script themes.ResultsProblematic life script themes were evident in each supervision session. Progress though the APES varied across themes and six different clients discussed during the sessions.ConclusionsThe supervisee's life script themes emerged prominently in supervision session content, and most were successfully navigated. The observations supported the theoretical suggestion that assimilation of supervisee unprocessed life script material may be a prominent component of routine professional supervision.
Spirolindemers A and B, Lindenane Sesquiterpenoid Oligomers Equipped with Oxaspiro[4.5]decane from Chloranthus henryi
Authors: Li Jixin , Chi Jun , Tang Pengfei , Sun Yunpeng , Lu Weijia , Xu Wenjun , Wang Yongyue , Luo Jun , Kong Lingyi 
Published: December 2021

Comprehensive SummarySpirolindemers A and B, unprecedented lindenane sesquiterpenoid dimer (1) and trimer (2) equipped with oxaspiro[4.5]decane unit, were discovered from the medicinal plant Chloranthus henryi. Their structures including absolute configurations were achieved by HRMS, NMR, ECD, X‐ray diffraction analyses, and quantum chemical calculations. Biogenetically, hetero‐ and homo‐Diels‐Alder additions may dominate the formation of oxaspiro[4.5]decane and spiro[4.5]decane skeletons, respectively. Compound 1 showed anti‐inflammatory activity by inhibiting the expression of iNOS and COX‐2.
Chronic urticaria patients are interested in apps to monitor their disease activity and control: A UCARE CURICT analysis
Authors: Cherrez‐Ojeda Ivan , Vanegas Emanuel , Cherrez Annia , Felix Miguel , Weller Karsten , Magerl Markus , Maurer Rasmus Robin , Mata Valeria L. , Kasperska‐Zajac Alicja , Sikora Agnieszka , Fomina Daria , Kovalkova Elena , Godse Kiran , Rao Nimmagadda Dheeraj , Khoshkhui Maryam , Rastgoo Sahar , Criado Roberta F. J. , Abuzakouk Mohamed , Grandon Deepa , Van Doorn Martijn B. A. , Rodrigues Valle Solange Oliveira , De Souza Lima Eduardo Magalhães , Thomsen Simon Francis , Ramón German D. , Matos Benavides Edgar E. , Bauer Andrea , Giménez‐Arnau Ana M. , Kocatürk Emek , Guillet Carole , Larco Jose Ignacio , Zhao Zuo‐Tao , Makris Michael , Ritchie Carla , Xepapadaki Paraskevi , Ensina Luis Felipe , Cherrez Sofia , Maurer Marcus 
Published: December 2021

AbstractBackgroundInformation/communication technologies such as mobile phone applications (apps) would enable chronic urticaria (CU) patients to self‐evaluate their disease activity and control. Yet, recently Antó et al (2021) reported a global paucity of such apps for patients with CU. In this analysis, we assessed patient interest in using apps to monitor CU disease activity and control using questions from the chronic urticaria information and communication technologies (CURICT) study.MethodsThe methodology for CURICT has been reported. Briefly, a 23‐item questionnaire was completed by 1841 CU patients from 17 UCAREs across 17 countries. Here, we analyzed patient responses to the CURICT questions on the use of apps for urticaria‐related purposes.ResultsAs previously published, the majority of respondents had chronic spontaneous urticaria (CSU; 63%; 18% chronic inducible urticaria (CIndU) [CIndu]; 19% with both), were female (70%) and in urban areas (75%). Over half of patients were very/extremely interested in an app to monitor disease activity (51%) and control (53%), while only ∼1/10 were not. Patients with both urticaria types versus those with CSU only (odds ratio [OR], 1.36 [1.03–1.79]) and females versus males (OR [95% CI], 1.47 [1.17–1.85]) were more likely to be very to extremely interested in an app to assess disease control.ConclusionsOverall, half of the patients with CU were very to extremely interested in using an app to assess their disease activity and control. Development of well‐designed apps, specific to disease types (CSU, CIndU, CSU + CIndU, etc), validated by experts across platforms would help improve the management and possibly outcomes of CU treatment while providing important patient information to be used in future research.
Silicate as a Versatile Matrix for the Aqueous Synthesis of Metal Sulfide Nanoparticles
Authors: Estrada‐Mendoza Tatiana A. , Burgess Thomas F. , Edirisinghe Dimuthu S. , Gonzalez Aleida G. , Khalaf Jawad N. , Brentley Fravel J. , McMillen Colin D. , Chumanov George 
Published: December 2021

AbstractThe addition of metals to the oligomeric sodium metasilicate in water results in insoluble metal silicate complexes that form nanoparticles, in which further chemical reactions can be carried out. Copper sulfide, copper tin sulfide, tin sulfide, bismuth sulfide and zinc sulfide doped with manganese nanoparticles were synthesized using this method. The silicate matrix resulted in a narrow particle size distribution and imparted long‐term stability to the nanoparticle suspensions. The reactions were monitored via UV‐Vis‐NIR spectroscopy, and the nanoparticles were characterized by AFM, powder X‐ray diffraction, and Raman spectroscopy. The described method is expected to become a general and versatile approach for aqueous synthesis of multimetallic, doped chalcogenide and other complex nanoparticles without the need of complicated chemical precursors, stabilizing agents, and multiple steps.