bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of Poor Inhabitant Number Using Least Square and Moving Average Method
Authors: Ekawati Ningrum 
Published: September 2021

<p>Poor population in South Kalimantan recently shows a decreased number for the last three years, compared to few previous years. The number of poor population differs from time to time. This dynamical scaled number has actually been a problem for South Kalimantan local government to take proper policies to solve this matter. It will then be necessary to predict potential number of poor population in the next year as the basis of subsequent policy making. This research will apply both Least Square and Moving Average methods as measurement to count prediction values. From the result, we can say that prediction analysis using those two methods is valid for predicting acquired number of potential people population based on its previous data due to its closest result to the actual condition. Reviewing the test result of last three years, the applied least square method shows validity of 92, 8%. Meanwhile, the applied moving average method shows validity of 98,8% both are considered valid.</p>
Nodes Deployment Scheme of Heterogeneous Wireless Sensor Network Based on Organic Small Molecule Model
Authors: Zhang Juwei , Wang Yu , Liu Yachuang , Li Qiangyi 
Published: September 2021

<p>For nodes deployment of heterogeneous sensor network, based on different probability sensing models of heterogeneous nodes, refer to organic small molecule model, ‘class molecule’ sensing model of heterogeneous nodes is proposed. Combined with DSmT data fusion model, the changes of network coverage ratio after using the new sensing model and data fusion algorithm is studied. According to the research results, the node-deployment strategy of heterogeneous sensor networks based on organic small molecule model (NHOS) is proposed. Sensor network simulation model is established using MATLAB software, the results show the effectiveness of the algorithm, the coverage of network and detection efficiency of nodes are improved, the lifetime of network is prolonged, energy consumption and the number of deployment nodes is reduced, and the scope of perceiving is expanded. As a result, NHOS can improve the detection performance of the network.</p>
Database of amphibian vouchers and records available at the Kerala Agricultural University Natural History Museum in Thrissur and an updated checklist of amphibians of Kerala, India
Authors: Nameer P.O. , M.S. Syamili  , A.F. Katakath  , U.S. Amal  , M.S. Abhin  , A. Devarajan  , S. Sajitha  , T. Arun  , J. Jobin  
Published: September 2021

The amphibian database of the Centre for Wildlife Studies of Kerala Agricultural University has the data that are either available as voucher specimens with the Kerala Agricultural University Natural History Museum (KAUNHM) or as photo vouchers and other opportunistic records from Kerala part of the southern Western Ghats between 2008 and 2020. This repository holds information on 91 species of amphibians belonging to 10 families, of which 87% are endemic to the Western Ghats and 34% are classified under the IUCN Red List threatened categories. This study highlights the significance of such digital databases that can serve as an immense source of regional biodiversity data, and therefore, biodiversity monitoring and conservation.
Continued use of retracted papers: Temporal trends in citations and (lack of) awareness of retractions shown in citation contexts in biomedicine
Authors: Hsiao Tzu-Kun , Schneider Jodi 
Published: September 2021

Abstract
We present the first database-wide study on the citation contexts of retracted papers, which covers 7,813 retracted papers indexed in PubMed, 169,434 citations collected from iCite, and 48,134 citation contexts identified from the XML version of the PubMed Central Open Access Subset. Compared with previous citation studies that focused on comparing citation counts using two time frames (i.e., preretraction and postretraction), our analyses show the longitudinal trends of citations to retracted papers in the past 60 years (1960–2020). Our temporal analyses show that retracted papers continued to be cited, but that old retracted papers stopped being cited as time progressed. Analysis of the text progression of pre- and postretraction citation contexts shows that retraction did not change the way the retracted papers were cited. Furthermore, among the 13,252 postretraction citation contexts, only 722 (5.4%) citation contexts acknowledged the retraction. In these 722 citation contexts, the retracted papers were most commonly cited as related work or as an example of problematic science. Our findings deepen the understanding of why retraction does not stop citation and demonstrate that the vast majority of postretraction citations in biomedicine do not document the retraction.
How Ibn Saud Became a Romanticized Legend in the U.S., British and French Press (1920–1953)
Authors: Briand Sylvie A. 
Published: September 2021

Abstract
Despite the vast research on Abdulaziz Ibn Saud, the founder of the Kingdom of Saudi Arabia, there has been little attention given to the impact of his representation by the British, French and U.S. press in the first half of the twentieth century. The man who built the kingdom in line with his Islamic sect’s doctrine has been portrayed as a puritan reformer and a modernist, in sharp contrast with the negative representation of other Arabs who happened to be fighting against French and British domination of the region at the time. This research is important for our understanding of how media representation was both a catalyst that contributed to building a reputation and a destiny for Ibn Saud and Saudi Arabia, and also a tool in the hands of the great powers of the time. This study is based on a critical examination of news articles and features published by French, British and American journalists from 1920 until Ibn Saud’s death in 1953.
Serial Readers United
Authors: Kaposi Ildiko , Al-Shammari Shahd 
Published: September 2021

Abstract
Through an exploration of Kuwait’s independent bookstores, the article challenges the reputation of Gulf Arab monarchies as generally lacking a reading culture. It treats independent bookstores as urban spaces designed to enable participation in the practices and rituals of reading books and as indicators of reading microcultures in the country. Run by readers and writers, independent bookstores fill a gap in the cultural landscape in order to cultivate highbrow readership. They nurture emerging communities of readers, creating intimate spaces that blur the boundaries of public and private. They balance art and commerce to assume roles as arbiters of taste, community centers, and literary-cultural societies. Aided by social media, their activities spill over into the wider community and expand beyond the borders of Kuwait, attesting to the resilience of historical patterns of the Arab world of letters and the emergence of the Gulf as a new center in the circuit.
Assessing the role of air-sea coupling in predicting Madden-Julian Oscillation with an atmosphere-ocean coupled model
Authors: Wu Jiye , Li Yue , Luo Jing-Jia , Jiang Xianan 
Published: September 2021

AbstractThe Madden-Julian Oscillation (MJO) provides an important source of sub-seasonal to seasonal (S2S) predictability. Improved MJO prediction can be beneficial to S2S prediction of global climate and associated weather extremes. In this study, hindcasts based on an atmosphere-ocean coupled general circulation model (CGCM) are compared to those based on atmosphere general circulation models (AGCMs) to investigate influences of air-sea interactions on MJO prediction. Our results suggest that MJO prediction skill can be extended about one week longer in the CGCM hindcasts than AGCM-only experiments, particularly for boreal winter predictions.Further analysis suggests that improved MJO prediction in the CGCM is closely associated with improved representation of moistening processes. Compared to the AGCM experiments, the CGCM better predicts the boundary-layer moisture preconditioning to the east of MJO convection, which is generally considered crucial for triggering MJO deep convection. Meanwhile, the widely extended east-west asymmetric structure in free-tropospheric moisture tendency anomalies relative to the MJO convection center as seen in the observations is also well predicted in the CGCM. Improved prediction of MJO moisture processes in CGCM is closely associated with better representation of the zonal scale of MJO circulation and stronger Kelvin waves to the east of MJO convection, both of which have been recently suggested conductive for MJO eastward propagation. The above improvements by including air-sea coupling could be largely attributed to the realistic MJO-induced SST fluctuations through the convection-SST feedback. This study confirms a critical role of atmosphere-ocean coupling for the improvement of MJO prediction.
Repositional Subtalar Arthrodesis Combined With Supramalleolar Osteotomy for Late-Stage Varus Ankle Arthritis With Hindfoot Valgus
Authors: Park Chul Hyun , Kim Jaeyoung , Kim Ji Beom , Lee Woo-Chun 
Published: September 2021

Background: Late-stage varus ankle arthritis is thought to be associated with varus of the tibial plafond and hindfoot. However, some late-stage varus arthritis show hindfoot valgus, which can be explained by subtalar subluxation with opposite directional motion between the talus and calcaneus. We hypothesized that late-stage varus ankle arthritis with hindfoot valgus could improve with repositional subtalar arthrodesis and supramalleolar osteotomy (SMO). The purpose of this study was to investigate the clinical and radiographic results of the repositional subtalar arthrodesis combined with SMO for late-stage varus ankle arthritis with hindfoot valgus. Methods: This study includes 16 consecutive patients (16 ankles) with late-stage varus ankle arthritis of Takakura stage 3-b and hindfoot valgus who were treated using repositional subtalar arthrodesis combined with SMO and followed for a minimum of 2 years. Clinical results were assessed with the visual analog scale (VAS) and the Foot Function Index (FFI). Radiographic results were assessed with standard parameters measured on weightbearing foot and ankle radiographs. Clinical and radiographic results were evaluated preoperatively and at the last follow-up. Results: VAS and FFI significantly improved after surgery. Mean talar tilt angle improved from 12.8 ± 2.8 degrees to 3.9 ± 3.1 degrees ( P < .001). Talus center migration and Meary angle significantly improved after surgery. Medial distal tibial angle, lateral talocalcaneal angle, hindfoot moment arm, and talonavicular coverage angle significantly changed after surgery. Radiographic stage improved in 15 ankles (93.8%) after surgery. Conclusion: In this series with minimum 2-year follow-up, we found that late-stage (Takakura stage 3-b) varus ankle arthritis with hindfoot valgus clinically and radiographically improved with repositional subtalar arthrodesis combined with SMO. Level of Evidence: Level IV, prognostic.
A clinically applicable gene expression–based score predicts resistance to induction treatment in acute myeloid leukemia
Authors: Moser Christian , Jurinovic Vindi , Sagebiel-Kohler Sabine , Ksienzyk Bianka , Batcha Aarif M. N. , Dufour Annika , Schneider Stephanie , Rothenberg-Thurley Maja , Sauerland Cristina M. , Görlich Dennis , Berdel Wolfgang E. , Krug Utz , Mansmann Ulrich , Hiddemann Wolfgang , Braess Jan , Spiekermann Karsten , Greif Philipp A. , Vosberg Sebastian , Metzeler Klaus H. , Kumbrink Jörg , Herold Tobias 
Published: September 2021

Abstract
Prediction of resistant disease at initial diagnosis of acute myeloid leukemia (AML) can be achieved with high accuracy using cytogenetic data and 29 gene expression markers (Predictive Score 29 Medical Research Council; PS29MRC). Our aim was to establish PS29MRC as a clinically usable assay by using the widely implemented NanoString platform and further validate the classifier in a more recently treated patient cohort. Analyses were performed on 351 patients with newly diagnosed AML intensively treated within the German AML Cooperative Group registry. As a continuous variable, PS29MRC performed best in predicting induction failure in comparison with previously published risk models. The classifier was strongly associated with overall survival. We were able to establish a previously defined cutoff that allows classifier dichotomization (PS29MRCdic). PS29MRCdic significantly identified induction failure with 59% sensitivity, 77% specificity, and 72% overall accuracy (odds ratio, 4.81; P = 4.15 × 10−10). PS29MRCdic was able to improve the European Leukemia Network 2017 (ELN-2017) risk classification within every category. The median overall survival with high PS29MRCdic was 1.8 years compared with 4.3 years for low-risk patients. In multivariate analysis including ELN-2017 and clinical and genetic markers, only age and PS29MRCdic were independent predictors of refractory disease. In patients aged ≥60 years, only PS29MRCdic remained as a significant variable. In summary, we confirmed PS29MRC as a valuable classifier to identify high-risk patients with AML. Risk classification can still be refined beyond ELN-2017, and predictive classifiers might facilitate clinical trials focusing on these high-risk patients with AML.
DNA damage repair system in C57BL/6 J mice is evolutionarily stable
Authors: Wang Xiaoyu , Wang San Ming 
Published: September 2021

Abstract
Background
DNA damage repair (DDR) system is vital in maintaining genome stability and survival. DDR consists of over 160 genes in 7 different pathways to repair specific type of DNA damage caused by external and internal damaging factors. The functional importance of DDR system implies that evolution could play important roles in maintaining its functional intactness to perform its function. Indeed, it has been observed that positive selection is present in BRCA1 and BRCA2 (BRCA), which are key genes in homologous recombination pathway of DDR system, in the humans and its close relatives of chimpanzee and bonobos. Efforts have been made to investigate whether the same selection could exist for BRCA in other mammals but found no evidence so far. However, as most of the studies in non-human mammals analyzed only a single or few individuals in the studied species, the observation may not reflect the true status in the given species. Furthermore, few studies have studied evolution selection in other DDR genes except BRCA. In current study, we used laboratory mouse C57BL/6 J as a model to address evolution selection on DDR genes in non-primate mammals by dynamically monitoring genetic variation across 30 generations in C57BL/6 J.

Results
Using exome sequencing, we collected coding sequences of 169 DDR genes from 44 C57BL/6 J individual genomes in 2018. We compared the coding sequences with the mouse reference genome sequences derived from 1998 C57BL/6 J DNA, and with the mouse Eve6B reference genome sequences derived from 2003 C57BL/6 J DNA, covering 30 generations of C57BL/6 J from 1998 to 2018. We didn’t identify meaningful coding variation in either Brca1 or Brca2, or in 167 other DDR genes across the 30 generations. In the meantime, we did identify 812 coding variants in 116 non-DNA damage repair genes during the same period, which served as a quality control to validate the reliability of our analytic pipeline and the negative results in DDR genes.

Conclusions
DDR genes in laboratory mouse strain C57BL/6 J were not under positive selection across its 30-generation period, highlighting the possibility that DDR system in rodents could be evolutionarily stable.
The impact of inhalation anesthetics on early postoperative cognitive function and recovery characteristics in Down syndrome patients: a randomized, double – blind study
Authors: Gkliatis Emmanouil , Makris Alexandros , Staikou Chryssoula 
Published: September 2021

Abstract
Background
Down syndrome (DS) is associated with intellectual disability. DS patients may be unable to cooperate and often require general anesthesia even for minor surgeries. Rapid recovery significantly contributes to fast-tracking. This prospective randomized, double - blind study investigates the impact of desflurane and sevoflurane on recovery and early postoperative cognitive function of these patients.

Methods
Forty-four patients undergoing dental surgery, were randomized to receive desflurane (DES-group) or sevoflurane (SEVO-group) for anesthesia maintenance. The primary outcome was postoperative cognitive function (Prudhoe Cognitive Function Test, PCFT) at 90 min and 4 h postoperatively. Secondary outcome measures were the time between volatile discontinuation and spontaneous breath, eye opening, extubation, orientation and response to commands, time to achieve an Aldrete score ≥ 9 in the Post-anesthesia Care Unit and time to fulfill discharge criteria (Post Anesthetic Discharge Scoring System, PADSS).

Results
At 90 min, PCFT scores significantly decreased from baseline in both groups. Nevertheless, at 4 h, in DES-group there was no significant change from baseline (p = 0.163), while in SEVO-group the decrease remained significant (p < 0.001). Desflurane was also found superior regarding recovery characteristics, such as time to eye opening (p = 0.021), spatial orientation (p = 0.004), response to commands (p = 0.004). Discharge criteria were met earlier in DES-group (p = 0.018 for Aldrete score / p < 0.001 for PADSS).

Conclusions
Desflurane was found superior to sevoflurane in terms of faster recovery and better preserved postoperative cognitive function in DS patients undergoing dental surgery. We suggest that desflurane, as part of a multimodal anesthetic approach, could be a useful agent to enhance early discharge from hospital of ambulatory patients with intellectual disability.

Trial registration
Registered with ClinicalTrials.gov (NCT02971254, principal investigator: E.G; November 2016).
Proteome-scale profiling reveals MAFF and MAFG as two novel key transcription factors involved in palmitic acid-induced umbilical vein endothelial cell apoptosis
Authors: Wang Mangyuan , Liu Fen , Fang Binbin , Huo Qiang , Yang Yining 
Published: September 2021

Abstract
Background
Vascular endothelial cell apoptosis is the leading risk factor of atherosclerosis (AS). The purpose of our study was to use a new generation high-throughput transcription factor (TF) detection method to identify novel key TFs in vascular endothelial cell apoptosis induced by palmitic acid (PA).

Methods
Human umbilical vein endothelial cells (HUVECs) were treated with 0, 300, or 500 µM PA. Candidate TFs in the three groups were identified by differential expression, pathway enrichment, Western Blot (WB), and RT-qPCR analyses. Apoptosis was assessed by fluorescence-activated cell sorting (FACS) using FITC-annexin V and propidium iodide staining.

Results
We established a HUVEC apoptosis model to simulate the process of atherosclerosis onset and identified 51 significant TFs. of the 51 TFs, v-maf musculoaponeurotic fibrosarcoma oncogene family protein G (MAFG) and v-maf musculoaponeurotic fibrosarcoma oncogene family protein F (MAFF), were matched to known AS signalling pathways and were validated by WB and RT-qPCR analyses in our study. Overexpression of MAFG or MAFF in HUVECs significantly inhibited PA-induced early apoptosis.

Conclusions
We identified MAFF and MAFG as novel key TFs in vascular endothelial cell apoptosis.
Detection of Coccidioides posadasii in a patient with meningitis using metagenomic next-generation sequencing: a case report
Authors: Mao Yuqiao , Li Xia , Lou Haibo , Shang Xiaoyu , Mai Yanjun , Yang Lan , Peng Fuhua , Fu Xihua 
Published: September 2021

Abstract
Background
Coccidioidomycosis is a systemic infection caused by dimorphic fungi Coccidioides spp. endemic to Southwestern United States and Central and South America. A history of residence and travel in these areas is essential for the diagnostic of coccidioidomycosis, which has highly variable symptoms ranging from asymptomatic to severe, disseminated infection, and even death. Immunocompromised patients of coccidioidomycosis experience a high risk of dissemination, chronic infection, and mortality. Meningitis is one of the most deleterious coccidioidomycosis and can cause various life-threatening complications.

Case presentation
Here we report a case of Coccidioides posadasii meningitis in a 49-year-old female who returned to China after one and a half years residence in Los Angeles, USA. The repeated routine cultures using CSF for bacteria or fungi were all negative. To hunt for an infectious etiology, the state-of-the-art technology metagenomic next-generation sequencing (mNGS) was then utilized, suggesting Coccidioides posadasii. Organizational pathological examination and polymerase-chain-reaction (PCR) results subsequently confirmed the mNGS detection.

Conclusion
To our knowledge, cases for coccidioidal meningitis have been rarely reported in China. While global travelling may spread this disease across continents and make the diagnosis more difficult. mNGS can detect almost all known pathogens with high sensitivity and specificity, especially for uncommon pathogen, such as Coccidioides posadasii in China.
The aetiology of pharyngotonsillitis in primary health care: a prospective observational study
Authors: Pallon Jon , Rööst Mattias , Sundqvist Martin , Hedin Katarina 
Published: September 2021

Abstract
Background
Few studies on pharyngotonsillitis have examined the clinical presentation of different aetiologies where pathogens have been detected using molecular methods. We aimed to assess how well clinical signs and symptoms can predict (1) the presence or absence of a broad range of viruses and bacteria, and (2) reconsultations for a sore throat or a complication.

Methods
In this descriptive observational prospective study in primary health care 220 patients aged 15–45 with suspected pharyngotonsillitis were sampled from nose, throat and blood and screened for 20 bacteria and viruses using polymerase chain reaction (PCR), culture and serology. Odds ratios (OR) and predictive values with 95% confidence intervals (CI) were used to show association between microbiological findings and clinical signs and symptoms. Patients were followed up after 3 months by reviewing electronic medical records.

Results
Both cough and coryza were more common in patients with only viruses (67%) than in patients with only bacteria (21%) (p < 0.001), whereas tonsillar coating was more common in patients with only bacteria (53%) than in patients with only viruses (29%) (p = 0.006). Tonsillar coating (adjusted OR 6.0; 95% CI 2.5–14) and a lack of cough (adjusted OR 3.5; 95% CI 1.5–8.0) were significantly associated with Streptococcus pyogenes (group A streptococci; GAS) and with any bacterial finding. A Centor score of 3–4 had a positive predictive value of 49% (95% CI 42–57) for GAS and 66% (95% CI 57–74) for any bacterial findings. The use of rapid antigen detection test for GAS increased the positive predictive value for this group to 93%.

Conclusions
Signs and symptoms, both single and combined, were insufficient to rule in GAS or other pathogens. However, both cough and coryza were useful to rule out GAS. The results support the clinical approach of restricting rapid antigen detection testing to patients with 3–4 Centor criteria. The low carriage rate of bacteria among asymptomatic controls implied that most detections in patients represented a true infection.