bluuebunny/crossref_metadata_2025_split huggingface dataset:
C-Reactive Protein, Interleukin-6, and Procalcitonin in Diagnosis of Late-Onset Bloodstream Infection in Very Preterm Infants
Authors: Berka Ivan , Korček Peter , Straňák Zbyněk 
Published: July 2021

Abstract

Background
Late-onset bloodstream infection (LOBSI) is common in very preterm infants. Early and accurate diagnosis is crucial for prognosis and outcome. We aimed to analyze the accuracy of routinely used inflammatory biomarkers in the diagnosis of LOBSI as compared to uninfected controls.

Methods
In this single-center, retrospective case-control study, interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) were routinely measured, when infection was clinically suspected. The definition of LOBSI was based on positive blood culture, clinical signs of infection, and onset more than 72 hours after birth.

Results
Among 285 enrolled infants, 66 developed LOBSI. IL-6 was superior to other markers, and levels greater than 100 ng/L had a sensitivity of 94% and a specificity of 99% for the presence of LOBSI. Receiver operating characteristic curve of IL-6 had area under the curve of 0.988 (95% CI = 0.975-1.00, P &lt; .001). The negative predictive value of IL-6, CRP, and PCT for optimal cutoff values was 99%, 95%, and 93%, respectively. The logistic regression model of IL-6 &gt; 100 ng/L or CRP &gt; 10 mg/L were successfully predicted LOBSI in 97.9% of cases.

Conclusions
The combination of IL-6 and CRP seems to have great potential in routine rapid diagnosis of LOBSI development. High negative predictive value of all tested markers could encourage the early discontinuation of antibiotic treatment.
Peritoneal defect herniation causing small bowel obstruction: a rare complication of transabdominal preperitoneal repair
Authors: Hannan Enda , Baird Olivia , Feeney Meghan , Condon Eoghan 
Published: July 2021

Abstract
Laparoscopic approaches to inguinal hernia repair are becoming increasingly more popular as they offer many advantages to open techniques including faster recovery and lower rates of wound infection. However, it is important to recognize complications associated with newer techniques which only become apparent with increased volume and experience. In this report, we describe a rare case of small bowel obstruction (SBO) secondary to peritoneal defect herniation post-transabdominal preperitoneal repair (TAPP). This is an uncommon complication that is sparsely reported in the literature but may have devastating consequences for the patient if unrecognized or mistakenly attributed to adhesional SBO. A high index of suspicion for internal herniation and a low index for reoperation are important with SBO in the early postoperative phase post-TAPP.
Steps and traces
Authors: Rot Jurriaan , Jacobs Bart , Levy Paul Blain 
Published: July 2021

Abstract
In the theory of coalgebras, trace semantics can be defined in various distinct ways, including through algebraic logics, the Kleisli category of a monad or its Eilenberg–Moore category. This paper elaborates two new unifying ideas: (i) coalgebraic,draftrules trace semantics is naturally presented in terms of corecursive algebras, and (ii) all three approaches arise as instances of the same abstract setting. Our perspective puts the different approaches under a common roof and allows to derive conditions under which some of them coincide.
Real-world, Multicenter Experience With Meropenem-Vaborbactam for Gram-Negative Bacterial Infections Including Carbapenem-Resistant Enterobacterales and Pseudomonas aeruginosa
Authors: Alosaimy Sara , Lagnf Abdalhamid M , Morrisette Taylor , Scipione Marco R , Zhao Jing J , Jorgensen Sarah C J , Mynatt Ryan , Carlson Travis J , Jo Jinhee , Garey Kevin W , Allen David , DeRonde Kailynn , Vega Ana D , Abbo Lilian M , Venugopalan Veena , Athans Vasilios , Saw Stephen , Claeys Kimberly C , Miller Mathew , Molina Kyle C , Veve Michael , Kufel Wesley D , Amaya Lee , Yost Christine , Ortwine Jessica , Davis Susan L , Rybak Michael J 
Published: July 2021

Abstract

Background
We aimed to describe the clinical characteristics and outcomes of patients treated with meropenem-vaborbactam (MEV) for a variety of gram-negative infections (GNIs), primarily including carbapenem-resistant Enterobacterales (CRE).

Methods
This is a real-world, multicenter, retrospective cohort within the United States between 2017 and 2020. Adult patients who received MEV for ≥72 hours were eligible for inclusion. The primary outcome was 30-day mortality. Classification and regression tree analysis (CART) was used to identify the time breakpoint (BP) that delineated the risk of negative clinical outcomes (NCOs) and was examined by multivariable logistic regression analysis (MLR).

Results
Overall, 126 patients were evaluated from 13 medical centers in 10 states. The most common infection sources were respiratory tract (38.1%) and intra-abdominal (19.0%) origin, while the most common isolated pathogens were CRE (78.6%). Thirty-day mortality and recurrence occurred in 18.3% and 11.9%, respectively. Adverse events occurred in 4 patients: nephrotoxicity (n = 2), hepatoxicity (n = 1), and rash (n = 1). CART-BP between early and delayed treatment was 48 hours (P = .04). MEV initiation within 48 hours was independently associated with reduced NCO following analysis by MLR (adusted odds ratio, 0.277; 95% CI, 0.081–0.941).

Conclusions
Our results support current evidence establishing positive clinical and safety outcomes of MEV in GNIs, including CRE. We suggest that delaying appropriate therapy for CRE significantly increases the risk of NCOs.
A co-fractionation mass spectrometry-based prediction of protein complex assemblies in the developing rice aleurone-subaleurone
Authors: Lee Youngwoo , Okita Thomas W. , Szymanski Daniel B. 
Published: July 2021

Abstract
Multiprotein complexes execute and coordinate diverse cellular processes such as organelle biogenesis, vesicle trafficking, cell signaling, and metabolism. Knowledge about their composition and localization provides useful clues about the mechanisms of cellular homeostasis and system-level control. This is of great biological importance and practical significance in heterotrophic rice (Oryza sativa) endosperm and aleurone–subaleurone tissues, which are a primary source of seed vitamins and stored energy. Dozens of protein complexes have been implicated in the synthesis, transport, and storage of seed proteins, lipids, vitamins, and minerals. Mutations in protein complexes that control RNA transport result in aberrant endosperm with shrunken and floury phenotypes, significantly reducing seed yield and quality. The purpose of this study was to broadly predict protein complex composition in the aleurone–subaleurone layers of developing rice seeds using co-fractionation mass spectrometry. Following orthogonal chromatographic separations of biological replicates, thousands of protein elution profiles were subjected to distance-based clustering to enable large-scale multimerization state measurements and protein complex predictions. The predicted complexes had predicted functions across diverse functional categories, including novel heteromeric RNA binding protein complexes that may influence seed quality. This effective and open-ended proteomics pipeline provides useful clues about system-level posttranslational control during the early stages of rice seed development.
COMPASS functions as a module of the INO80 chromatin remodeling complex to mediate histone H3K4 methylation in Arabidopsis
Authors: Shang Ji-Yun , Lu Yu-Jia , Cai Xue-Wei , Su Yin-Na , Feng Chao , Li Lin , Chen She , He Xin-Jian 
Published: July 2021

Abstract
In the INO80 chromatin remodeling complex, all of the accessory subunits are assembled on the following three domains of INO80: N-terminal domain (NTD), HSA domain, and ATPase domain. Although the ATPase and HSA domains and their interacting accessory subunits are known to be responsible for chromatin remodeling, it is largely unknown how the accessory subunits that interact with the INO80 NTD regulate chromatin status. Here, we identify both conserved and nonconserved accessory subunits that interact with the three domains in the INO80 complex in Arabidopsis thaliana. While the accessory subunits that interact with all the three INO80 domains can mediate transcriptional repression, the INO80 NTD and the accessory subunits interact with it can contribute to transcriptional activation even when the ATPase domain is absent, suggesting that INO80 has an ATPase-independent role. A subclass of the COMPASS histone H3K4 methyltransferase complexes interact with the INO80 NTD in the INO80 complex and function together with the other accessory subunits that interact with the INO80 NTD, thereby facilitating H3K4 trimethylation and transcriptional activation. This study suggests that the opposite effects of the INO80 complex on transcription are required for the balance between vegetative growth and flowering under diverse environmental conditions.
Large-scale field phenotyping using backpack LiDAR and CropQuant-3D to measure structural variation in wheat
Authors: Zhu Yulei , Sun Gang , Ding Guohui , Zhou Jie , Wen Mingxing , Jin Shichao , Zhao Qiang , Colmer Joshua , Ding Yanfeng , Ober Eric S. , Zhou Ji 
Published: July 2021

AbstractPlant phenomics bridges the gap between traits of agricultural importance and genomic information. Limitations of current field-based phenotyping solutions include mobility, affordability, throughput, accuracy, scalability, and the ability to analyze big data collected. Here, we present a large-scale phenotyping solution that combines a commercial backpack Light Detection and Ranging (LiDAR) device and our analytic software, CropQuant-3D, which have been applied jointly to phenotype wheat (Triticum aestivum) and associated 3D trait analysis. The use of LiDAR can acquire millions of 3D points to represent spatial features of crops, and CropQuant-3D can extract meaningful traits from large, complex point clouds. In a case study examining the response of wheat varieties to three different levels of nitrogen fertilization in field experiments, the combined solution differentiated significant genotype and treatment effects on crop growth and structural variation in the canopy, with strong correlations with manual measurements. Hence, we demonstrate that this system could consistently perform 3D trait analysis at a larger scale and more quickly than heretofore possible and addresses challenges in mobility, throughput, and scalability. To ensure our work could reach non-expert users, we developed an open-source graphical user interface for CropQuant-3D. We, therefore, believe that the combined system is easy-to-use and could be used as a reliable research tool in multi-location phenotyping for both crop research and breeding. Furthermore, together with the fast maturity of LiDAR technologies, the system has the potential for further development in accuracy and affordability, contributing to the resolution of the phenotyping bottleneck and exploiting available genomic resources more effectively.
Thermostable D-amino acid decarboxylases derived from Thermotoga maritima diaminopimelate decarboxylase
Authors: Marjanovic Antonija , Ramírez-Palacios Carlos J , Masman Marcelo F , Drenth Jeroen , Otzen Marleen , Marrink Siewert-Jan , Janssen Dick B 
Published: July 2021

Abstract
Diaminopimelate decarboxylases (DAPDCs) are highly selective enzymes that catalyze the common final step in different lysine biosynthetic pathways, i.e. the conversion of meso-diaminopimelate (DAP) to L-lysine. We examined the modification of the substrate specificity of the thermostable decarboxylase from Thermotoga maritima with the aim to introduce activity with 2-aminopimelic acid (2-APA) since its decarboxylation leads to 6-aminocaproic acid (6-ACA), a building block for the synthesis of nylon-6. Structure-based mutagenesis of the distal carboxylate binding site resulted in a set of enzyme variants with new activities toward different D-amino acids. One of the mutants (E315T) had lost most of its activity toward DAP and primarily acted as a 2-APA decarboxylase. We next used computational modeling to explain the observed shift in catalytic activities of the mutants. The results suggest that predictive computational protocols can support the redesign of the catalytic properties of this class of decarboxylating PLP-dependent enzymes.
Managing Households’ Expectations with Unconventional Policies
Authors: D’Acunto Francesco , Hoang Daniel , Weber Michael 
Published: July 2021

Abstract
Binding lower bounds on interest rates and large government deficits limit the scope of fiscal and monetary policies to stimulate households’ spending through financial intermediaries and firms. Policy makers have thus been implementing unconventional policies that aim to increase households’ spending directly through managing their expectations. We first show theoretically and empirically that higher inflation expectations increase households’ consumption. We then design a difference-in-differences strategy to assess the effectiveness of unconventional fiscal policy and forward guidance, both of which aim to raise aggregate demand via managing expectations. Whereas unconventional fiscal policy increases households’ expectations and spending, forward guidance announcements do not
LEVELS OF NATURAL AND ANTHROPOGENIC RADIONUCLIDES IN SEDIMENTS OF SOME MOROCCAN COASTAL AREAS AND DOSE ASSESSMENT BASED ON ERICA TOOL
Authors: Ait Bouh H , Laissaoui A , Ziad N , El Kotbi M C , Benmhammed A 
Published: July 2021

Abstract
In this work, we considered the concentrations of natural and anthropogenic radionuclides (namely the 40K, 210Pb, 226Ra, 137Cs, 234Th, 228Th and 228Ra) in sediments from Moroccan coast areas by considering estuaries (Sebou and Loukkos) and marine ecosystems (M’diq Bay and three Lagoons: Moulay Bousselham, Sidi Moussa and Oualidia). Sediment samples were analyzed using Gamma spectrometry. The objective was to establish radioactivity levels in Moroccan coastal areas as well as radiological risk assessment by using the ERICA tool. The software allows the estimation of dose rates to biota (a set of reference organisms by default). The highest activity concentrations were found in sediment samples of Sidi Moussa Lagoon, possibly due to the anthropogenic activities, while the lowest levels were reported in Sebou estuary, attributed most probably to a flooding event that occurred in the same year of sampling. Also, 210Pb and 40K have the most significant concentrations, while 137Cs has the lowest concentrations with a great resemblance with similar works. The World Wide Average concentration of 226Ra was exceeded in the three lagoons and that of 40K only exceeded at Sidi Moussa Lagoon. The application of ERICA tool allowed the assessment of total dose rates that are mainly due to internal exposure with strong contribution of 226Ra mainly for phytoplankton in the case of marine ecosystems and insect larvae, mollusc-bivalve, mollusc-gastropod and zooplankton for estuary ecosystems. The total dose rates were far lesser than the admissible dose rate proposed by ERICA tool (10 μGy h−1) and, therefore, unlikely to cause harmful effects to organisms.
Biopsychosocial Predictors of Depression and Anxiety Symptoms among First-Generation Black African Immigrants
Authors: Saasa Sherinah , Miller Selina 
Published: July 2021

AbstractFew studies examine factors associated with mental health distress among immigrants from African countries. Using cross-sectional data from first-generation Black African immigrants across the United States (N = 180), this study examined biopsychosocial factors that influence depression and anxiety symptoms among African immigrants in the United States. Ordinary least squares regression was conducted to analyze the data. Approximately 22 percent of the sample reported depression and anxiety symptoms in the moderate to severe range. Results indicated that being male, substance use, discrimination, and loneliness were significantly associated with worse depression and anxiety symptoms. In addition, worries about safety and financial strain were associated with increased mental health distress. Loneliness also moderated the association between discrimination and depression and anxiety symptoms. Findings imply that relational interventions in direct practice settings may play a critical role in helping African immigrants ameliorate depression and anxiety symptoms. This study supports the use of the biopsychosocial approach in assessment and intervention of mental health symptoms as well as a systems approach when understanding the experiences of African immigrants.
Comparing Pressure Injury Incidence Based on Repositioning Intervals and Support Surfaces in Acute Care Settings: A Quasi-Experimental Pragmatic Study
Authors: Choi Jeong Sil , Hyun Seon Young , Chang Sun Ju 
Published: July 2021

ABSTRACT

OBJECTIVE
To compare pressure injury (PI) incidence based on repositioning intervals and support surfaces in acute care settings.

METHODS
This pragmatic, quasi-experimental trial recruited a total of 251 critically ill patients who were at low or moderate risk for PI development. Participants were assigned to three interventions: a 2-hour repositioning interval using an air mattress, a 2-hour repositioning interval using a foam mattress, or a 3-hour repositioning interval using a foam mattress. Data were collected by nurses every shift over the course of 14 days. Pressure injury incidence was analyzed using a χ
2 test.

RESULTS
There were no statistically significant differences in PI incidence between the groups with a 2-hour repositioning interval. However, the PI incidence in the group using a foam mattress with a 3-hour repositioning interval was significantly lower than in the group using an air mattress with a 2-hour repositioning interval (odds ratio, 0.481; 95% confidence interval, 0.410–0.565).

CONCLUSIONS
The findings showed that PIs decreased when the repositioning interval was extended from every 2 hours to every 3 hours while using foam mattresses. This study suggests that a 3-hour repositioning interval using a foam mattress could be applied to reduce the risk of PI development for patients at low or moderate risk.
Common, But Neglected: A Comprehensive Review of Leg Ulcers in Sickle Cell Disease
Authors: Sahu Tarun , Verma Henu Kumar , Ganguly Satyaki , Sinha Meenakshi , Sinha Ramanjan 
Published: July 2021

ABSTRACT

OBJECTIVE
To compile available evidence to better understand the management of leg ulcers in sickle cell disease (SCD), as well as describe potential therapeutic steps that may be required to improve the quality of life of patients with SCD leg ulcers.

DATA SOURCES
MEDLINE, PubMed, EMBASE, and Web of Science databases

STUDY SELECTION
A comprehensive search was conducted to retrieve relevant studies using the keywords “sickle cell disease and leg ulcer,” “ulcer treatments, diagnosis and sickle cell,” and “wound sickle cell.” Studies published through July 2020 were included.

DATA EXTRACTION
Two independent authors selected all studies that assessed the relationship between leg ulcer and SCD identified from online databases.

DATA SYNTHESIS
The authors have summarized updated information on pathophysiology (vasculopathy linked to chronic hemolysis and endothelial dysfunction), diagnosis, and available treatment options to unravel the dermohematologic connection between leg ulcers and SCD.

CONCLUSIONS
It is the authors’ hope that this detailed discussion of the information available on leg ulcers and SCD will lead to a better appreciation of this clinical problem by the clinicians and researchers and in turn have a long-term positive effect on the quality of life of patients with SCD. Researchers should design new trials considering these insights and potential therapeutic approaches based on current knowledge.
Effect of Masker Head Orientation, Listener Age, and Extended High-Frequency Sensitivity on Speech Recognition in Spatially Separated Speech
Authors: Braza Meredith D. , Corbin Nicole E. , Buss Emily , Monson Brian B. 
Published: July 2021

Objectives:
Masked speech recognition is typically assessed as though the target and background talkers are all directly facing the listener. However, background speech in natural environments is often produced by talkers facing other directions, and talker head orientation affects the spectral content of speech, particularly at the extended high frequencies (EHFs; >8 kHz). This study investigated the effect of masker head orientation and listeners’ EHF sensitivity on speech-in-speech recognition and spatial release from masking in children and adults.

Design:
Participants were 5- to 7-year-olds (n = 15) and adults (n = 34), all with normal hearing up to 8 kHz and a range of EHF hearing thresholds. Speech reception thresholds (SRTs) were measured for target sentences recorded from a microphone directly in front of the talker’s mouth and presented from a loudspeaker directly in front of the listener, simulating a target directly in front of and facing the listener. The maskers were two streams of concatenated words recorded from a microphone located at either 0° or 60° azimuth, simulating masker talkers facing the listener or facing away from the listener, respectively. Maskers were presented in one of three spatial conditions: co-located with the target, symmetrically separated on either side of the target (+54° and −54° on the horizontal plane), or asymmetrically separated to the right of the target (both +54° on the horizontal plane).

Results:
Performance was poorer for the facing than for the nonfacing masker head orientation. This benefit of the nonfacing masker head orientation, or head orientation release from masking (HORM), was largest under the co-located condition, but it was also observed for the symmetric and asymmetric masker spatial separation conditions. SRTs were positively correlated with the mean 16-kHz threshold across ears in adults for the nonfacing conditions but not for the facing masker conditions. In adults with normal EHF thresholds, the HORM was comparable in magnitude to the benefit of a symmetric spatial separation of the target and maskers. Although children benefited from the nonfacing masker head orientation, their HORM was reduced compared to adults with normal EHF thresholds. Spatial release from masking was comparable across age groups for symmetric masker placement, but it was larger in adults than children for the asymmetric masker.

Conclusions:
Masker head orientation affects speech-in-speech recognition in children and adults, particularly those with normal EHF thresholds. This is important because masker talkers do not all face the listener under most natural listening conditions, and assuming a midline orientation would tend to overestimate the effect of spatial separation. The benefits associated with EHF audibility for speech-in-speech recognition may warrant clinical evaluation of thresholds above 8 kHz.