bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 in trauma: a propensity-matched analysis of COVID and non-COVID trauma patients
Authors: Yeates Eric O. , Grigorian Areg , Schellenberg Morgan , Owattanapanich Natthida , Barmparas Galinos , Margulies Daniel , Juillard Catherine , Garber Kent , Cryer Henry , Tillou Areti , Burruss Sigrid , Figueras Ryan Arthur , Mladenov Georgi , Brenner Megan , Firek Christopher , Costantini Todd , Santorelli Jarrett , Curry Terry , Wintz Diane , Biffl Walter L. , Schaffer Kathryn B. , Duncan Thomas K. , Barbaro Casey , Diaz Graal , Johnson Arianne , Chinn Justine , Naaseh Ariana , Leung Amanda , Grabar Christina , Nahmias Jeffry 
Published: May 2021

Abstract
Purpose
There is mounting evidence that surgical patients with COVID-19 have higher morbidity and mortality than patients without COVID-19. Infection is prevalent amongst the trauma population, but any effect of COVID-19 on trauma patients is unknown. We aimed to evaluate the effect of COVID-19 on a trauma population, hypothesizing increased mortality and pulmonary complications for COVID-19-positive (COVID) trauma patients compared to propensity-matched COVID-19-negative (non-COVID) patients.

Methods
A retrospective analysis of trauma patients presenting to 11 Level-I and II trauma centers in California between 1/1/2019–6/30/2019 and 1/1/2020–6/30/2020 was performed. A 1:2 propensity score model was used to match COVID to non-COVID trauma patients using age, blunt/penetrating mechanism, injury severity score, Glasgow Coma Scale score, systolic blood pressure, respiratory rate, and heart rate. Outcomes were compared between the two groups.

Results
A total of 20,448 trauma patients were identified during the study period. 53 COVID trauma patients were matched with 106 non-COVID trauma patients. COVID patients had higher rates of mortality (9.4% vs 1.9%, p = 0.029) and pneumonia (7.5% vs. 0.0%, p = 0.011), as well as a longer mean length of stay (LOS) (7.47 vs 3.28 days, p < 0.001) and intensive care unit LOS (1.40 vs 0.80 days, p = 0.008), compared to non-COVID patients.

Conclusion
This multicenter retrospective study found increased rates of mortality and pneumonia, as well as a longer LOS, for COVID trauma patients compared to a propensity-matched cohort of non-COVID patients. Further studies are warranted to validate these findings and to elucidate the underlying pathways responsible for higher mortality in COVID trauma patients.
Increased tibial tubercle-trochlear groove and patellar height indicate a higher risk of recurrent patellar dislocation following medial reefing
Authors: Ahrend Marc-Daniel , Eisenmann Tobias , Herbst Moritz , Gueorguiev Boyko , Keller Gabriel , Schmidutz Florian , Döbele Stefan , Schröter Steffen , Ihle Christoph 
Published: May 2021

Abstract
Purpose
Identifying anatomical risk factors on recurrent dislocation after medial reefing is important for deciding surgical treatment. The present study aimed to retrospectively analyze the preoperative magnetic resonance imaging (MRI)-based parameters of patients treated with medial reefing and whether these parameters lead to a higher risk of recurrent dislocation.

Methods
Fifty-five patients (18.6 ± 6.6 years) who underwent medial reefing after primary traumatic patellar dislocation (84% with medial patellofemoral ligament [MPFL] rupture) were included. Patients were followed up for at least 24 months postoperatively (3.8 ± 1.2 years) to assess the incidence of recurrent patellar dislocation. In patients without recurrent dislocation, the Kujala and subjective IKDC scores were assessed. Moreover, the tibial tubercle-trochlear groove (TT-TG), sulcus angle, patellar tilt, patellar shift, and lateral trochlea index (LTI) were measured. The patellar height was measured using the Caton-Dechamps (CDI), Blackburne-Peel (BPI), and Insall-Salvati index (ISI). The cohort was subclassified into two groups with and without recurrent dislocation. Differences between groups were analyzed with respect to the MRI parameters.

Results
Forty percent had a pathological sulcus angle of > 145°, 7.2% had an LTI of < 11°, 47.3% had a patellar tilt of > 20°, and 36.4% had a TT-TG of ≥ 16 mm. Increased patellar height was observed in 34.5, 65.5, and 34.5% of the patients as per CDI, BPI, and ISI, respectively. Nineteen (34.5%) patients suffered from recurrent dislocation. Compared with patients without recurrent dislocation, those with recurrent dislocation had a significantly lower LTI (p = 0.0467). All other parameters were not significantly different between the groups. Risk factor analysis showed higher odds ratios (OR > 2), although not statistically significant, for MPFL rupture (OR 2.05 [95% confidence interval 0.38–11.03], LTI (6.6 [0.6–68.1]), TT-TG (2.9 [0.9–9.2]), and patellar height according to ISI (2.3 [0.7–7.5]) and CDI (2.3 [0.7–7.5])). Patients without recurrent dislocation had a Kujala score of 93.7 ± 12.1 (42–100) points and an IKDC score of 90.6 ± 11.7 (55.2–100) points.

Conclusion
Anatomical, MRI-based parameters should be considered before indicating medial reefing. A ruptured MPFL, an LTI < 11°, a TT-TG ≥ 16 mm, a patellar tilt > 20 mm, and an increased patellar height according to ISI and CDI were found to be associated, although not significantly, with a higher risk (OR > 2) of recurrent patellar dislocation after medial reefing. Thorough preoperative analysis is crucial to reduce the risk of recurrent dislocation in young patient cohorts.

Level of evidence
Level IV
Cementless unicompartmental knee arthroplasty results in higher pain levels compared to the cemented technique: a prospective register study
Authors: Gifstad Tone , Nordskar Jørgen Jebens , Egeberg Tarjei , Wik Tina Strømdal , Winther Siri Bjørgen 
Published: May 2021

Abstract
Purpose
In recent years, the preferred fixation method for unicompartmental knee arthroplasty (UKA) has changed from cemented to cementless. The aim of this study was to compare patient-reported outcome measures (PROMs) from the cemented versus cementless techniques two- and twelve-months post-operation.

Methods
From 2015 to 2019, 187 cemented and 261 cementless UKAs were included based on an institutional registry. The Oxford Unicompartmental Knee System™ (Zimmer Biomet, Bridgend, United Kingdom) was used for all patients. Three experienced surgeons performed all procedures. Data were collected pre- and peroperatively, and at two- and twelve-months postoperatively. PROMs included pain (evaluated on a numeric rating scale [NRS] during activity and at rest), and knee function (evaluated with the disease-specific short form of the Knee injury and Osteoarthritis Outcome Score [KOOS-PS]). Patients also rated postoperative joint function (better, unchanged, uncertain or worse) and were asked, “based on your experience to date, would you go through the surgery again?”. Duration of surgery was noted and revisions during the first post-operative year were evaluated.

Results
The cemented group reported significantly lower activity-related pain at both two- and twelve-month follow-up. This was also the case for pain at rest at twelve-month follow-up, and KOOS-PS at two-month follow-up. Duration of surgery (adjusted for surgeon differences) was eight minutes less on average with the cementless technique. Eleven prosthetic joint infections (PJIs) were found following the cementless fixation technique compared to three using the cemented implant.

Conclusion
UKA cases with cemented implants had lower pain scores during activity two and twelve months after surgery compared with those who had cementless implants. Differences in favor of the cemented group were also found for pain at rest one year after surgery and for KOOS-PS two months after. Surgery was significantly shorter in duration in the cementless group, but a relatively high number of PJIs were found in that same group.

Level of evidence
Level II.
Dynamic alteration in miRNA and mRNA expression profiles at different stages of chronic arsenic exposure-induced carcinogenesis in a human cell culture model of skin cancer
Authors: Banerjee Mayukh , Ferragut Cardoso Ana , Al-Eryani Laila , Pan Jianmin , Kalbfleisch Theodore S. , Srivastava Sudhir , Rai Shesh N. , States J. Christopher 
Published: May 2021

AbstractChronic arsenic exposure causes skin cancer, although the underlying molecular mechanisms are not well defined. Altered microRNA and mRNA expression likely play a pivotal role in carcinogenesis. Changes in genome-wide differential expression of miRNA and mRNA at 3 strategic time points upon chronic sodium arsenite (As3+) exposure were investigated in a well-validated HaCaT cell line model of arsenic-induced cutaneous squamous cell carcinoma (cSCC). Quadruplicate independent HaCaT cell cultures were exposed to 0 or 100 nM As3+ for up to 28-weeks (wk). Cell growth was monitored throughout the course of exposure and epithelial-mesenchymal transition (EMT) was examined employing immunoblot. Differentially expressed miRNA and mRNA profiles were generated at 7, 19, and 28-wk by RNA-seq, followed by identification of differentially expressed mRNA targets of differentially expressed miRNAs through expression pairing at each time point. Pathway analyses were performed for total differentially expressed mRNAs and for the miRNA targeted mRNAs at each time point. RNA-seq predictions were validated by immunoblot of selected target proteins. While the As3+-exposed cells grew slower initially, growth was equal to that of unexposed cells by 19-wk (transformation initiation), and exposed cells subsequently grew faster than passage-matched unexposed cells. As3+-exposed cells had undergone EMT at 28-wk. Pathway analyses demonstrate dysregulation of carcinogenesis-related pathways and networks in a complex coordinated manner at each time point. Immunoblot data largely corroborate RNA-seq predictions in the endoplasmic reticulum stress (ER stress) pathway. This study provides a detailed molecular picture of changes occurring during the arsenic-induced transformation of human keratinocytes.
Tolerance to neurochemical and behavioral effects of the hallucinogen 25I-NBOMe
Authors: Herian Monika , Skawski Mateusz , Wojtas Adam , Sobocińska Małgorzata K. , Noworyta Karolina , Gołembiowska Krystyna 
Published: May 2021

Abstract
Rationale
4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe) is a potent serotonin 5-HT2A/2C receptor agonist with hallucinogenic activity. There is no data on the 25I-NBOMe effect on brain neurotransmission and animal performance after chronic administration.

Objectives
We examined the effect of a 7-day treatment with 25I-NBOMe (0.3 mg/kg/day) on neurotransmitters’ release and rats’ behavior in comparison to acute dose.

Methods
Changes in dopamine (DA), serotonin (5-HT), acetylcholine (ACh), and glutamate release were studied using microdialysis in freely moving rats. The hallucinogenic activity was measured in the wet dog shake (WDS) test. The animal locomotion was examined in the open field (OF) test, short-term memory in the novel object recognition (NOR) test. The anxiogenic/anxiolytic properties of the drug were tested using the light/dark box (LDB) test.

Results
Repeated administration of 25I-NBOMe decreased the response to a challenge dose of DA, 5-HT, and glutamatergic neurons in the frontal cortex as well as weakened the hallucinogenic activity in comparison to acute dose. In contrast, striatal and accumbal DA and 5-HT release and accumbal but not striatal glutamate release in response to the challenge dose of 25I-NBOMe was increased in comparison to acute treatment. The ACh release was increased in all brain regions. Behavioral tests showed a motor activity reduction and memory deficiency in comparison to a single dose and induction of anxiety after the drug’s chronic and acute administration.

Conclusions
Our findings suggest that multiple injections of 25I-NBOMe induce tolerance to hallucinogenic activity and produce alterations in neurotransmission. 25I-NBOMe effect on short-term memory, locomotor function, and anxiety seems to be the result of complex interactions between neurotransmitter pathways.
On the Mumford–Tate conjecture for hyperkähler varieties
Authors: Floccari Salvatore 
Published: May 2021

AbstractWe study the Mumford–Tate conjecture for hyperkähler varieties. We show that the full conjecture holds for all varieties deformation equivalent to either an Hilbert scheme of points on a K3 surface or to O’Grady’s ten dimensional example, and all of their self-products. For an arbitrary hyperkähler variety whose second Betti number is not 3, we prove the Mumford–Tate conjecture in every codimension under the assumption that the Künneth components in even degree of its André motive are abelian. Our results extend a theorem of André.
Stereotactic Percutaneous Electrochemotherapy as Primary Approach for Unresectable Large HCC at the Hepatic Hilum
Authors: Luerken L. , Doppler M. , Brunner S. M. , Schlitt H. J. , Uller W. 
Published: May 2021

AbstractElectrochemotherapy (ECT) is a novel non-thermal ablative technique that combines chemotherapy and the application of electric pulses for reversible cell membrane electroporation. This method was recently performed in the treatment of deep-seated liver tumors during open surgery but experience about percutaneous ECT is rare and further developments like combination of percutaneous ECT with stereotactic navigated devices may be very promising. We report on a case of a 4.7 × 4.5 × 3.5 cm unresectable HCC at the hepatic hilum adjacent to the major vessels and the bile duct that was successfully treated using percutaneous ECT in combination with stereotactic navigation. Follow-up imaging 6 weeks and 6 months after ECT showed complete response.
Functional syndromes and symptom-orientated aftercare after esophagectomy
Authors: Ukegjini Kristjan , Vetter Diana , Fehr Rebecca , Dirr Valerian , Gubler Christoph , Gutschow Christian A. 
Published: May 2021

Abstract
Background
Surgery is the cornerstone of esophageal cancer treatment but remains burdened with significant postoperative changes of gastrointestinal function and quality of life.

Purpose
The aim of this narrative review is to assess and summarize the current knowledge on postoperative functional syndromes and quality of life after esophagectomy for cancer, and to provide orientation for the reader in the challenging field of functional aftercare.

Conclusions
Post-esophagectomy syndromes include various conditions such as dysphagia, reflux, delayed gastric emptying, dumping syndrome, weight loss, and chronic diarrhea. Clinical pictures and individual expressions are highly variable and may be extremely distressing for those affected. Therefore, in addition to a mostly well-coordinated oncological follow-up, we strongly emphasize the need for regular monitoring of physical well-being and gastrointestinal function. The prerequisite for an effective functional aftercare covering the whole spectrum of postoperative syndromes is a comprehensive knowledge of the pathophysiological background. As functional conditions often require a complex diagnostic workup and long-term therapy, close interdisciplinary cooperation with radiologists, gastroenterologists, oncologists, and specialized nutritional counseling is imperative for successful management.
Incidence and risk factors for chronic kidney disease in patients with congenital heart disease
Authors: Fang Nai-Wen , Chen Yu-Chieh , Ou Shih-Hsiang , Yin Chun-Hao , Chen Jin-Shuen , Chiou Yee-Hsuan 
Published: May 2021

Abstract
Backgrounds
Chronic kidney disease (CKD) is underdiagnosed in children with congenital heart disease (CHD). Our aim was to study the incidence of CKD in CHD children and identify risk factors for CKD.

Methods
CHD patients were enrolled from the Kaohsiung Veterans General Hospital database between 2010 and 2019. Patient age at enrollment was age at first visit to the hospital. The end of follow-up was marked by the last measurement of serum creatinine, urine protein-to-creatinine ratio (UPCR), or urine microalbumin-to-creatinine ratio (UACR) after enrollment, and only patients who underwent the aforementioned tests in 2 different years were included. Patients with an estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73m2 were diagnosed as having CKD and were further classified into clinically recognized CKD (CR-CKD, defined as eGFR <60 mL/min/1.73m2, UPCR >0.5, or UACR >30 mg/g) and non-clinically recognized CKD (NCR-CKD). Their demographic data, CHD category, heart surgery types, medications, and contrast-related examinations during follow-up were collected.

Results
The study included 359 CHD patients, of whom 167 (46.5%) developed CKD (18 patients with CR-CKD and 341 with NCR-CKD). Patients with CR-CKD were significantly older at enrollment than patients with NCR-CKD. Corrective heart surgery may be a protective factor for CKD. Furthermore, cyanotic heart disease, two or more image-related contrast exposures, and diuretic use may be associated with CKD.

Conclusion
CHD patients have a high incidence of CKD. The early detection of CKD and prompt corrective heart surgery for CHD may be beneficial for kidney function.

Graphical abstract
Ultra-high speed video observations of intracloud lightning flash initiation
Authors: Stolzenburg Maribeth , Marshall Thomas C. , Bandara Sampath , Hurley Brian , Siedlecki Raymond 
Published: May 2021

AbstractThis study describes results from video observations of five intracloud flashes located ≤ 20 km from the camera and recorded with 6.1 µs exposure time and 6.66 µs frame intervals. Video data are supported with electric field change (E-change) and VHF measurements, with emphasis on the flash initiating event (IE) and initial breakdown (IB) stage. In four of the five flashes, the IE is accompanied by weak luminosity, ≤ 5% above background, lasting for 300–500 µs. Two of these four IEs were positive Narrow Bipolar Events (NBEs) with VHF powers of 43 and 990 W; these are the first (known) data showing visible light detected with a positive NBE. Two other IEs with weak luminosity had powers of 0.5 and 1 W, and the IE with no detected luminosity had a VHF power of 3 W. A typical IB cluster consists of several narrow pulses and one classic pulse in E-change data (along with many VHF pulses), and each example flash has 2–10 IB clusters in the first 5–50 ms. The luminosity of IB clusters was substantially greater than IE luminosity, ranging from 10 to 40% above background in four examples, while for one flash with 10 IB clusters, the luminosity range was 35–360% above background (average 190%). Luminosity durations of IB clusters were 520–1750 µs with average 1210 µs. For both IEs and IB clusters, increases in the detected luminosity were closely timed with substantial VHF emissions and decreased when VHF emissions weakened.
A Plane-Stress Damage Model for Vectran Laminated Composite
Authors: Abdullah S. I. B. Syed , Iannucci L. , Greenhalgh E. S. , Ahmad Z. 
Published: May 2021

AbstractThe aim of this paper is to present a plane-stress damage model based on the Classical Lamination Theory (CLT), developed for polymer fibre-based composite. The proposed numerical model utilises a damage mechanics methodology coupled with fracture mechanics to predict composite failure, particularly under quasi-static and dynamic loadings. In addition, the proposed constitutive equations consider a single secant modulus to describe its tensile and compressive modulus, as opposed to the physically-proposed tier models for polymer fibres which possesses a ‘skin–core’ structure. The result of single element and coupon-level modelling showed excellent correlation with the experimental results. It is expected that the proposed numerical model will be able to predict, up to a considerable accuracy, the response of the composite under low and high velocity impact loadings.
Dynamic simulation of high-purity twin-bed N2-PSA plants
Authors: Marcinek A. , Möller A. , Guderian J. , Bathen D. 
Published: May 2021

AbstractAt present, nitrogen production from air by pressure swing adsorption (PSA) is simulated almost exclusively at low product purity levels (< 99% N2). However, with increasing global demand for highly purified gases provided by energy-efficient separation processes the requirement for either extensive experimental research in the high-purity range or predictive computer simulations arises. This paper presents a mathematical model of a twin-bed PSA plant equipped with a carbon molecular sieve (Shirasagi MSC CT-350) for the generation of high-purity nitrogen (99.9–99.999% N2). The model is implemented in the process simulator Aspen Adsorption™. The influence of operating conditions as well as the cycle organisation on the process performance is validated, especially the influence of pressure, temperature, half-cycle time, purge flow rate, and cutting time. The precision of the performance prediction by numerical simulations is critically discussed. Based on the new insights efficiency improvement strategies with a focus on reduced energy consumption are introduced and discussed by means of radar charts.
Development of the START Program for Academic Readiness and Its Impact on Behavioral Self-regulation in Japanese Kindergarteners
Authors: Imai-Matsumura Kyoko , Schultz David 
Published: May 2021

AbstractThe “first-grade problem” of the lack of concentration, listening, and following of instruction has been widely identified among Japanese kindergarten students. To promote their executive functioning and self-regulation to prevent this issue, we developed the Social Thinking and Academic Readiness Training (START) program. The experimental group in which the program was implemented contained 79 children (average age = 73.22 months), and the standard practices group contained 70 children (average age = 72.91 months). Before and after the intervention, the children underwent tasks to test their behavioral self-regulation and executive function (working memory). For behavioral self-regulation, a significant interaction occurred between condition (experimental and standard practices) and time (pre- and post-test), suggesting that these 6 START lessons promoted self-regulation. However, no effects were found on either auditory or visual memory. Teacher reports in surveys were consistent with the executive functioning outcomes, reporting improvement in children’s concentration, listening, and self-regulation skills.
Fast Vacuum Fluctuations and the Emergence of Quantum Mechanics
Authors: ’t Hooft Gerard 
Published: May 2021

AbstractFast moving classical variables can generate quantum mechanical behavior. We demonstrate how this can happen in a model. The key point is that in classically (ontologically) evolving systems one can still define a conserved quantum energy. For the fast variables, the energy levels are far separated, such that one may assume these variables to stay in their ground state. This forces them to be entangled, so that, consequently, the slow variables are entangled as well. The fast variables could be the vacuum fluctuations caused by unknown super heavy particles. The emerging quantum effects in the light particles are expressed by a Hamiltonian that can have almost any form. The entire system is ontological, and yet allows one to generate interference effects in computer models. This seemed to lead to an inexplicable paradox, which is now resolved: exactly what happens in our models if we run a quantum interference experiment in a classical computer is explained. The restriction that very fast variables stay predominantly in their ground state appears to be due to smearing of the physical states in the time direction, preventing their direct detection. Discussions are added of the emergence of quantum mechanics, and the ontology of an EPR/Bell Gedanken experiment.