bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecologies of Public Trust: The NHS COVID-19 Contact Tracing App
Authors: Samuel Gabrielle , Lucivero Frederica , Johnson Stephanie , Diedericks Heilien 
Published: October 2021

AbstractIn April 2020, close to the start of the first U.K. COVID-19 lockdown, the U.K. government announced the development of a COVID-19 contact tracing app, which was later trialled on the U.K. island, the Isle of Wight, in May/June 2020. United Kingdom surveys found general support for the development of such an app, which seemed strongly influenced by public trust. Institutions developing the app were called upon to fulfil the commitment to public trust by acting with trustworthiness. Such calls presuppose that public trust associated with the app can emerge if the conditions for trustworthiness are met and that public trust is simplistic, i.e., linearly the sum of each member of the publics’ individual – U.K. government trust relationship. Drawing on a synthesis of the trust literature and fifteen interviews with members of the public trialling the app on the Isle of Wight, this paper aims to explore what trust mechanisms and relationships are at play when thinking about public trust in the context of the U.K. COVID-19 app. We argue that public trust is a complex social phenomenon and not linearly correlated with institutional trustworthiness. As such, attention needs to widen from calls for trustworthy infrastructures as a way to build public trust, to a deeper understanding of those doing the trusting; in particular, what or whom do people place their trust in (or not) when considering whether using the app and why. An understanding of this will help when trying to secure public trust during the implementation of necessary public health measures.
Ethylenediurea (EDU) spray effects on willows (Salix sachalinensis F. Schmid) grown in ambient or ozone-enriched air: implications for renewable biomass production
Authors: Agathokleous Evgenios , Kitao Mitsutoshi , Shi Cong , Masui Noboru , Abu-ElEla Shahenda , Hikino Kyohsuke , Satoh Fuyuki , Koike Takayoshi 
Published: October 2021

AbstractGround-level ozone (O3) is a widespread air pollutant causing extensive injuries in plants. However, its effects on perennial energy crops remain poorly understood due to technical difficulties in cultivating fast-growing shrubs for biomass production under O3 treatment on the field. Here we present the results of a two-year evaluation in the framework of which willow (Salix sachalinensis F. Schmid) shrubs were exposed to ambient (AOZ) or elevated (EOZ) O3 in two successive growing seasons (2014, 2015) and treated with 0 (EDU0) or 400 mg L−1 (EDU400) ethylenediurea spray in the second growing season. In 2014, EOZ altered the chemical composition of both top young and fallen leaves, and a novel mechanism of decreasing Mg in fallen leaves while highly enriching it in young top leaves was revealed in shrubs exposed to EOZ. In 2015, EDU400 alleviated EOZ-induced decreases in leaf fresh mass to dry mass ratio (FM/DM) and leaf mass per area (LMA). While EDU400 protected against EOZ-induced suppression of the maximum rate at which leaves can fix carbon (Amax) in O3-asymptomatic leaves, it did not alleviate EOZ-induced suppression of the maximum rates of carboxylation (VCmax) and electron transport (Jmax) and chlorophylls a, b, and a + b in the same type of leaves. In O3-symptomatic leaves, however, EDU400 alleviated EOZ-induced suppression of chlorophylls a and a + b, indicating different mode of action of EDU between O3-asymptomatic and O3-symptomatic leaves. Extensive herbivory occurred only in AOZ-exposed plants, leading to suppressed biomass production, while EOZ also led to a similar suppression of biomass production (EDU0 × EOZ vs. EDU400 × EOZ). In 2016, carry-over effects were also evaluated following cropping and transplantation into new ambient plots. Effects of EOZ in the preceding growing seasons extended to the third growing season in the form of suppressed ratoon biomass production, indicating carry-over effect of EOZ. Although EDU400 protected against EOZ-induced suppression of biomass production when applied in 2015, there was no carry-over effect of EDU in the absence of EDU treatment in 2016. The results of this study provide novel mechanistic understandings of O3 and EDU modes of action and can enlighten cultivation of willow as energy crop.
Revisional One Anastomosis Gastric Bypass with a 150-cm Biliopancreatic Limb After Failure of Adjustable Gastric Banding: Mid-Term Outcomes and Comparison Between One- and Two-Stage Approaches
Authors: Petrucciani Niccolò , Martini Francesco , Benois Marine , Kassir Radwan , Boudrie Hubert , Van Haverbeke Olivier , Hamid Celine , Juglard Gildas , Costa Gianluca , Debs Tarek , Liagre Arnaud 
Published: October 2021

Abstract
Purpose
Laparoscopic adjustable gastric banding (LAGB) was a common procedure worldwide but associated with a high rate of long-term failure. This study aims to evaluate the safety and effectiveness of conversion to one anastomosis gastric bypass (OAGB) after failed LAGB.

Materials and Methods
We undertook a retrospective analysis of a prospectively maintained database in a tertiary referral center for bariatric surgery. All cases of revisional OAGB with a biliopancreatic limb (BPL) of 150 cm after failed LAGB performed between 2010 and 2016 were analyzed.

Results
Overall, 215 patients underwent conversion from LAGB to OAGB. Indication for surgery was primary weight loss (WL) failure in 30.7% of cases and long-term complications in the remaining patients, with or without associated weight regain. At the time of OAGB, the mean age was 43.2 ± 10.5 years and the mean BMI was 42 ± 6.9. Overall postoperative morbidity was 13.5%. The postoperative abscess ± leak rate was 5.9% in the overall population. Two years after OAGB, 9.7% of patients were lost to follow-up, % excess weight loss (EWL) was 88.2 ± 23.9, and % total weight loss (TWL) was 38.7 ± 9.3. At 5 years, 16.6% of patients were lost to follow-up, %EWL was 82.4 ± 25, and %TWL was 36.1 ± 10. There was no statistical difference in complication rates or WL results between the one-stage and two-stage approaches.

Conclusion
OAGB with a 150-cm BPL represents a safe and effective option after failed LAGB. Both synchronous OAGB and two-step revisional OAGB guarantee satisfying results in terms of postoperative morbidity and WL outcomes.

Graphical abstract (PLEASE CORRECT THE GRAPHICAL ABSTRACT !!! 215 PATIENTS INSTEAD OF 250
Vocal Cord Hemangioma: A Common Tumor in an Unusual Localization. A Case Report with Short Review of Literature
Authors: Piombino Eliana , Broggi Giuseppe , Grillo Calogero , Bonanno Antonio , Cocuzza Salvatore , La Mantia Ignazio , Caltabiano Rosario 
Published: October 2021

AbstractLaryngeal adult-type hemangiomas are very rare lesions, more frequent in men, whose optimal treatment consists of microlaryngoscopical excision. We herein report a case of larynx cavernous hemangioma in a 64-year-old woman with hoarseness for about six months. Histologically, the tumor was composed of multiple vessels embedded in an edematous stroma.
Best of ASCO 2021: new data from triple-negative breast cancer
Authors: Singer Christian 
Published: October 2021

SummaryThis year’s ASCO Annual Meeting has been a showcase for the overwhelming success of novel, targeted therapies, particularly in a tumor entity that has – until recently – been felt to be only treatable with chemotherapy. New data are extremely encouraging, but also highlight the need for target identification beyond the classical clinicopathological factors. Both, the Olympia and the Neotala study have been performed in BRCA-mutated tumors, and their results clearly point to the necessity to offer germline testing to HER2-negative high risk early breast cancer. In addition, GeparNuevo once more highlights the fact that immunotherapy is here to stay, not only in the advanced breast cancer setting, but also in early stage breast cancer. The side effect profile is acceptable, and long-term outcome a real improvement to conventional chemotherapy.
Work and children in Spain: challenges and opportunities for equality between men and women
Authors: Hupkau Claudia , Ruiz-Valenzuela Jenifer 
Published: October 2021

AbstractOver the past decades, Spain has seen a striking convergence between women’s and men’s participation in the labour market. However, this convergence has stalled since the early 2010s. We show that women still fare worse in several important labour market dimensions. Gender inequalities are further aggravated among people with children. Women with children under 16 are much more likely to be unemployed, work part-time or on temporary contracts than men with children of the same age. We show that it is unlikely that preferences alone can account for these gaps. A review of the evidence shows that family policies, such as paternity leave expansions, financial incentives in the form of tax credits for working mothers and subsidised or free childcare for very young children, could help reduce the motherhood penalty. However, such policies are likely to be more effective if combined with advances in breaking up traditional gender roles.
Fan design assessment for BLI propulsion systems
Authors: Mennicken M. , Schoenweitz D. , Schnoes M. , Schnell R. 
Published: October 2021

AbstractCivil aviation is aiming at fuel efficient aircraft concepts. Propulsion systems using boundary layer ingestion (BLI) are promising to reach this goal. The focus of this study is on the DLR UHBR fan stage of a tube and wing aircraft with rear-integrated engines. In this integration scenario the propulsion system and especially the fan stage receives distorted inflow in steady-state flight conditions. The distortion pattern and distortion intensity are dependent on the operating conditions. Consequently, the interaction of the fan and the distortion changes over the flight envelope. The first part of the paper aims at gaining knowledge of the BLI fan performance in the operating points end of field, approach, cruise (CR) and top of climb (TOC) using high-fidelity, unsteady RANS approaches. The analysis includes fan map performance metrics and a deeper insight into the flow field at CR and TOC. The preliminary design of a fan stage requires fast turn-around times, which are not fulfilled by high-fidelity approaches. Therefore, a fast, throughflow-based methodology is developed, which enables aerodynamicists to design distortion-tolerant fans. The main characteristics of the methodology is outlined in the second part. Consequently, the methodology is taken advantage of to investigate parameter sensitivities in terms of tip speed, blade thickness, solidity, the annulus geometry and a non-axisymmetric stator. This study suggests that distortion-tolerant fans should be designed at higher tip speeds than conventional design experience recommends to limit the local operating point excursion.
Is vulnerability segmentation at the leaf-stem transition a drought resistance mechanism? A theoretical test with a trait-based model for Neotropical canopy tree species
Authors: Levionnois Sébastien , Ziegler Camille , Heuret Patrick , Jansen Steven , Stahl Clément , Calvet Emma , Goret Jean-Yves , Bonal Damien , Coste Sabrina 
Published: October 2021

Abstract

Key message

Leaf-stem vulnerability segmentation predicts lower xylem embolism resistance in leaves than stem. However, although it has been intensively investigated these past decades, the extent to which vulnerability segmentation promotes drought resistance is not well understood. Based on a trait-based model, this study theoretically supports that vulnerability segmentation enhances shoot desiccation time across 18 Neotropical tree species.

Context
Leaf-stem vulnerability segmentation predicts lower xylem embolism resistance in leaves than stems thereby preserving expensive organs such as branches or the trunk. Although vulnerability segmentation has been intensively investigated these past decades to test its consistency across species, the extent to which vulnerability segmentation promotes drought resistance is not well understood.

Aims
We investigated the theoretical impact of the degree of vulnerability segmentation on shoot desiccation time estimated with a simple trait-based model.

Methods
We combined data from 18 tropical rainforest canopy tree species on embolism resistance of stem xylem (flow-centrifugation technique) and leaves (optical visualisation method). Measured water loss under minimum leaf and bark conductance, leaf and stem capacitance, and leaf-to-bark area ratio allowed us to calculate a theoretical shoot desiccation time (tcrit).

Results
Large degrees of vulnerability segmentation strongly enhanced the theoretical shoot desiccation time, suggesting vulnerability segmentation to be an efficient drought resistance mechanism for half of the studied species. The difference between leaf and bark area, rather than the minimum leaf and bark conductance, determined the drastic reduction of total transpiration by segmentation during severe drought.

Conclusion
Our study strongly suggests that vulnerability segmentation is an important drought resistance mechanism that should be better taken into account when investigating plant drought resistance and modelling vegetation. We discuss future directions for improving model assumptions with empirical measures, such as changes in total shoot transpiration after leaf xylem embolism.
A comparison of FreeStyle Libre 2 to self-monitoring of blood glucose in children with type 1 diabetes and sub-optimal glycaemic control: a 12-week randomised controlled trial protocol
Authors: Styles Sara , Wheeler Ben , Boucsein Alisa , Crocket Hamish , de Lange Michel , Signal Dana , Wiltshire Esko , Cunningham Vicki , Lala Anita , Cutfield Wayne , de Bock Martin , Serlachius Anna , Jefferies Craig 
Published: October 2021

Abstract
Purpose
Frequent glucose monitoring is necessary for optimal glycaemic control. Second-generation intermittently scanned glucose monitoring (isCGM) systems inform users of out-of-target glucose levels and may reduce monitoring burden. We aim to compare FreeStyle Libre 2 (Abbott Diabetes Care, Witney, U.K.) to self-monitoring of blood glucose in children with type 1 diabetes and sub-optimal glycaemic control.

Methods
This open-label randomised controlled trial will enrol 100 children (4–13 years inclusive, diagnosis of type 1 diabetes ≥ 6 months, HbA1c 58–110 mmol/mol [7.5–12.2%]), from 5 New Zealand diabetes centres. Following 2 weeks of blinded sensor wear, children will be randomised 1:1 to control or intervention arms. The intervention (duration 12 weeks) includes second-generation isCGM (FreeStyle Libre 2) and education on using interstitial glucose data to manage diabetes. The control group will continue self-monitoring blood glucose. The primary outcome is the difference in glycaemic control (measured as HbA1c) between groups at 12 weeks. Pre-specified secondary outcomes include change in glucose monitoring frequency, glycaemic control metrics and psychosocial outcomes at 12 weeks as well as isCGM acceptability.

Discussion
This research will investigate the effectiveness of the second-generation isCGM to promote recommended glycaemic control. The results of this trial may have important implications for including this new technology in the management of children with type 1 diabetes.

Trial registration
This trial was prospectively registered with the Australian New Zealand Clinical Trials Registry on 19 February 2020 (ACTRN12620000190909p) and the World Health Organization International Clinical Trials Registry Platform (Universal Trial Number U1111-1237-0090).
The Dilemma of Penile Prosthesis Implantation in Sex Offenders
Authors: Zhang JJ H. , DeWitt-Foy Molly , Jankowski Jane , Wood Hadley M. 
Published: October 2021

ABSTRACT

Background
Penile prosthesis surgeons face an ethical dilemma when confronted with a sex offender who seeks surgical management of erectile dysfunction.

Aim
To provide practice guidelines to screen and manage patients with a history of sexual violence prior to surgery.

Methods
Three urologists with expertise in penile prosthesis surgery and 1 medical bioethicist were asked to contribute their opinions and provide recommendations to address this controversial topic.

Outcomes
Expert opinion supported by analysis of available literature and institutional experience.

RESULTS
The authors review current United States legislation, published literature on sex offender registration, and institutional data on the prevalence of sex offenders among men seeking penile prosthesis placement. Within a context established by medical bioethical principles, the authors propose a practice guideline for screening sex offenders prior to penile implantation surgery and referral for trained psychological evaluation prior to surgical management.

Strengths & Limitations
Strengths: multidisciplinary approach in data acquisition including bioethical and legal review. Limitations: Lack of available evidence regarding recidivism risk in sex offenders who undergo penile prosthesis placement.

CONCLUSION
Sex offenders exist among the population of patients seeking surgical placement of a penile prosthesis. A standardized practice guideline for management of this population should be employed with the intention to reduce future harm.
Towards Mass Individualisation: setting the scope and industrial implication
Authors: Sikhwal Ravi K , Childs Peter R N 
Published: October 2021

AbstractWithin the last few years, a need for renewed product personalisation has been observed in some markets such as consumer electronics, fashion to meet the exact demands of the customers. Product customisation emphasises the fulfilment of explicit requirements of a defined market segment, but product individualisation targets at satisfying the particular needs of a customer. Mass Individualisation (MI) is a new product design approach comprising of an open hardware platform and multiple modules to be integrated with the platform. It gives freedom to end-users to integrate different modules into the platform as per their choice. Technological and strategic integration of all actors involved in the design process is the primary focus of this research. This paper identifies key areas which need to be focussed on to realise this approach and convert it into an industrial practice by an explorative study of existing product design and customisation approaches. An industrial survey was conducted, and results for the industrial implication and insights on this approach are presented. The findings show that the end product from product design for MI will be more creative and innovative by the networking of all actors, and offers more individualised and technologically advanced products.
Defining relations of quantum symmetric pair coideal subalgebras
Authors: Kolb Stefan , Yakimov Milen 
Published: October 2021

AbstractWe explicitly determine the defining relations of all quantum symmetric pair coideal subalgebras of quantised enveloping algebras of Kac–Moody type. Our methods are based on star products on noncommutative${\mathbb N}$-graded algebras. The resulting defining relations are expressed in terms of continuousq-Hermite polynomials and a new family of deformed Chebyshev polynomials.
Stories as evidence
Authors: Murphy-Hollies Kathleen , Bortolotti Lisa 
Published: October 2021

Abstract
People often use personal stories to support and defend their views. But can a personal story be evidence? A story tells us that a certain event can happen and has already happened to someone, but it may not always help us understand what caused the event or predict how likely that event is to happen again in the future. Moreover, people confabulate. That is, when they tell stories about their past, they are likely to distort reality in some way. When people who lack access to what motivated past behaviour are asked why they made a choice, they tend to offer plausible considerations in support of that choice, even if those considerations could not have played a motivating role in bringing about their behaviour. When people experience impairments in autobiographical memory, they tend to fill the gaps in their own story by reconstructing significant events to match their interests, values, and conception of themselves. This means that people often offer a curated version of the events they describe. In this paper, we argue that the pervasiveness of confabulation does not rule out that personal stories can be used as evidence but invites us to reflect carefully about what they are evidence of. And this is especially important in the context of digital storytelling, because stories shared on online platforms can exert even greater influence on what people think and do.
Spatial interactions between two nematode species along the intestine of the wood mouse Apodemus sylvaticus from woodland and grassland sites in southern England
Authors: Lewis J.W. , Morley N.J. , Behnke J.M. 
Published: October 2021

Abstract
The distributions of the nematode parasites Heligmosomoides polygyrus and Syphacia stroma were quantified in three equal-length sections along the intestine of wood mice (Apodemus sylvaticus) trapped in three different locations in the south of England. The distribution of H. polygyrus did not change in the presence of S. stroma, this species being largely confined to the anterior third of the intestine, whether S. stroma was or was not present. However, while in single infections with S. stroma, worms were equally distributed in the anterior and middle sections of the intestine, in the presence of H. polygyrus, a higher percentage of worms was located in the middle section. This was a dose-dependent response by S. stroma to increasing worm burdens with H. polygyrus, and even relatively low intensities of infection with H. polygyrus (e.g. ≤10 worms) were sufficient to cause a posterior redistribution of S. stroma into the middle section. A similar posterior shift in the percentage distribution of S. stroma in the intestine was evident in juvenile and mature mice of both sexes, and in mice from all three study sites. The ecological significance of these results is discussed.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta as a potential biomarker for Opisthorchis viverrini infection and cholangiocarcinoma
Authors: Prasopdee Sattrachai , Yingchutrakul Yodying , Roytrakul Sittiruk , Pholhelm Montinee , Phanaksri Teva , Kunjantarachot Anthicha , Kulsantiwong Jutharat , Butthongkomvong Kritiya , Tesana Smarn , Sathavornmanee Thanakrit , Thitapakorn Veerachai 
Published: October 2021

AbstractThe human liver fluke Opisthorchis viverrini (Ov), the primary risk factor for cholangiocarcinoma (CHCA), is a parasite endemic to southeast Asian countries. With no effective treatments for CHCA currently available, early diagnosis and treatment of Ov infection remains the only practical method for the prevention of CHCA. In this study, plasma phosphoproteomes of patients in the non-Ov infection, non-cholangiocarcinoma subject group (non-OVCCA), the asymptomatic Ov infected group (OV), and the CHCA group (CCA), were investigated to identify potential biomarkers for Ov infection and CHCA. The AKT signalling pathway was found to be up-regulated. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB), an upstream signalling molecule, was selected as a potential biomarker and evaluated using indirect enzyme-linked immunosorbent assay (ELISA). Results demonstrated evidence that levels of PIK3CB in both the OV group and CCA group was statistically different compared to the non-OVCCA group (P < 0.01). However, the levels of PIK3CB between the OV group and the CCA group were found not to be statistically different. Sensitivity and specificity for OV using OD450 cut-off at >1.570 was 76 and 72%, respectively. For CCA, sensitivity and specificity using OD450 cut-off at >1.398 was 68 and 76%, respectively. Application of indirect ELISA detecting plasma PIK3CB will be of great benefit for screening of opisthorchiasis and CHCA.