bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invasive inflammatory fibroid polyp of the stomach: A case report and literature review
Authors: Yang Xingrong , Guo Sitong , Meng Ke , Tao Juan 
Published: February 2025

Rationale:
Inflammatory fibrous polyp (IFP) is a distinct fibroblastic neoplasm with a predilection for the stomach and ileum. It usually presents prominent inflammatory infiltration, particularly eosinophils, and has been widely considered benign tumors without malignant biological behaviors. However, rare invasive cases have been reported.

Patient concerns:
A 75-year-old woman presented with unexplained hematemesis, dizziness, and weakness for 3 hours. Physical examination revealed upper abdominal tenderness on palpation.

Diagnoses:
Contrast-enhanced computed tomography revealed a 6 cm nodule with a high-density shadow and ring enhancement with well-defined borders in the gastric body. Gastroscopy showed multiple gastric polyps as well as a gastric submucosal mass with surface ulceration and mucosal disruption. Emergency laboratory results revealed anemia symptoms with an erythrocyte count of 2.63 × 1012/L and a hemoglobin level of 58.00 g/L. A laparoscopic distal gastrectomy was performed. The pathological results support the diagnosis of invasive IFP, and the tumor cells were infiltrated into gastric’s serosa layer.

Interventions:
The patient underwent laparoscopic distal gastrectomy resection. In addition, the patient received blood transfusion therapy for severe anemia, including Leukocyte privative red blood cell and Fresh frozen plasma.

Outcomes:
The patient was discharged home 2 weeks after surgery. There was no evidence of recurrence within the 4 years of surgery.

Lessons:
Except the common gastrointestinal stromal tumor and leiomyoma, IFP should also be considered by pathologists in the diagnosis of primary gastric non-epithelial tumor. Our case also emphasizes the invasive nature of IFP, a rare non benign biological feature (only 5 cases have been reported previously). Although it is very rare, it represents the potential development of the tumor, and should be paid attention to by pathologists and physicians. Otherwise, we report this case because of the first case of an IFP presenting with both gastritis cystica polyposa and inverted hyperplastic poly.
The effect of ultrasound-guided drug injection at Neiguan point on the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy
Authors: Pan Ren , He Lilan , Xu Wenqiang , Luo Xuejing , Qin Xiarong 
Published: February 2025

Background:
This study explores the feasibility and effectiveness of ultrasound-guided acupoint injection at Neiguan acupoint to prevent postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy.

Methods:
A total of 60 patients undergoing laparoscopic cholecystectomy in the General Surgery Department of Zhejiang Hospital from February 2021 to August 2021 were enrolled in this study. The patients were randomly divided into the injection group (n = 30) and the control group (n = 30). The patients in the injection group received ultrasound-guided injections of tropisetron at bilateral Neiguan acupoints, while those in the control group received intravenous injections of tropisetron. The incidence of PONV within 24 hours after surgery, the need for “rescue” treatment, the incidence of puncture complications, and patients’ satisfaction with PONV management were evaluated.

Result:
Neiguan point can be accurately located by ultrasound guidance. Compared with the control group, the incidence of PONV was significantly decreased in the Injection group within 0 to 6 hours after surgery, and the vomiting rate was decreased within 6 to 12 hours after surgery (P < .05).

Conclusion:
Ultrasound-guided drug injection at Neiguan to prevent PONV has the characteristics of visualization and accuracy, which is easy to promote and use, and the effect is satisfactory.
Diagnosis of early neurobrucellosis using metagenomic next-generation sequencing of the cerebrospinal fluid in nonepidemic zone: Case report and lecture review
Authors: Liu Haijun , Li Qianhua , Ouyang Xia , Li Qingfeng , Min Yu , Dai Lie 
Published: February 2025

Rationale:

Brucella neuropathy is a rare clinical condition, particularly in nonendemic areas, where it often presents with nonspecific symptoms such as fever and headaches, leading to frequent misdiagnoses. In these regions, Brucella antibodies are not routinely tested, and the positive rate of blood cultures is relatively low during the early stage of the disease. In addition, the low culture-positive rate of cerebrospinal fluid (CSF) means that many neurobrucellosis diagnoses rely on peripheral blood cultures or Brucella antibodies, which is not rigorous. This is problematic because the treatment of central nervous system brucellosis differs significantly from that of other types of brucellosis. The purpose of this study is to provide a method for the early diagnosis of Brucella neuropathy in nonendemic areas. We present a case of early-stage neurobrucellosis diagnosed using metagenomic next-generation sequencing (mNGS) of CSF. This approach helps avoid delaying diagnosis in the early stage in nonepidemic areas, potentially reducing the duration before diagnosis, which is of great significance for timely and appropriate treatment.

Patient concerns:
The patient had fever, mild headache, and a slight increase in CSF leukocytes.

Diagnoses:
CSF mNGS detected Brucella, which was later confirmed by serum Brucella antibody testing.

Interventions:
The patient was treated with rifampicin, doxycycline, and ceftriaxone.

Outcomes:
The patient experienced significant relief from the headache, and the fever did not recur. Subsequent examinations revealed no abnormalities in the CSF leukocytes or mNGS results.

Lessons:
We reviewed 10 articles on brucellosis diagnosed using mNGS, including 7 articles on neurobrucellosis (10 cases). Our review highlights the sensitivity of mNGS as a powerful tool for early detection of neurobrucellosis in the CSF. The common symptoms include fever and headache, with brain magnetic resonance imaging detecting lesions in most cases. CSF mNGS results varied, with only a few positive Brucella cultures or antibody tests.
Auricular acupressure for insomnia in women with breast cancer: A systematic review and meta-analysis of randomized controlled trials
Authors: Huang Xin-Rui , Xu Min , Xu Yan , Wang Shu-Jie , Ni Fei-Lin 
Published: February 2025

Background:
Breast cancer as the malignant tumor with the highest incidence and mortality rate among the global female population. Insomnia is a common complaint in breast cancer patients, more than one-third (38–47%) of breast cancer patients suffer it. Auricular acupressure (AA), a non-pharmacological therapy, has been used in the studies to intervene in insomnia in breast cancer patients. The objective of this systematic review and meta-analysis is to investigate the efficacy and safety of AA therapy in intervening with insomnia in breast cancer.

Methods:
A systematic literature search was performed for 10 databases up to January of 2024 to identify randomized control trials (RCTs). The methodological quality of RCTs was assessed independently using the Cochrane Handbook for Systematic Reviews of Interventions. The quality of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation approach. Data were screened and extracted independently using predesigned forms. The meta-analysis was conducted using RevMan 5.3 software, P-value < .05 means statistically significant.

Results:
This review included 15 studies from 3 different countries with a total of 1125 adult participants. The pooled results showed that AA significantly in improving sleep quality (mean difference [MD] = ‐3.36, 95% confidence interval [CI]: [‐4.65, −2.07], P < .001) and life quality (MD = ‐7.82, 95% CI: [‐14.76, ‐0.88], P = .03). Based on data from sleep monitoring devices, AA was valuable for improving sleep efficiency (MD = ‐3.63, 95% CI: [‐4.19,-3.07], P = .03) in breast cancer patients. Adverse events were reported in 5 RCTs. Common adverse reactions include auricular skin allergic reaction (10/259, 3.9%), bruising (7/259, 2.7%), pain (3/259, 1.2%), and local pressure ulcers on the auricular points (2/259, 0.8%). The evidence grade was moderate because of the substantial heterogeneity among studies. Heart, Shenmen, and Subcortex were the 3 most numerous auricular points, with a total share of up to 71.70%.

Conclusion:
This systematic review and meta-analysis demonstrates the efficacy and safety of AA in intervening insomnia in breast cancer patients, providing a basis for the selection of clinical auricular points. However, the high-quality RCTs in existence are not enough, and more rigorous trials are needed to identify the efficacy of AA and insomnia.
Bibliometric and visual analysis of breast cancer-related lymphedema: Knowledge structure, research status, and future trends
Authors: Shang Rui , Zhou Jie , Pan Ting , Wang Fengyang , Jin Hui , Nan Xi , Chen Xinhua , Song Chenyu 
Published: February 2025

Background:
As the survival rate of breast cancer patients increases, breast cancer-related lymphedema (BCRL) has gradually received attention from researchers. This study aims to sort out and summarize the relevant studies on BCRL using bibliometric analysis and to explore future research trends.

Methods:
In this study, we searched the Web of Science Core Collection for publications related to BCRL, analyzed the publication trends by applying Microsoft Excel 2019, and analyzed authors, cited journals, journal mapping overlays, cited references, and keywords by applying CiteSpace (v.6.1.R3 Advanced). SCImago Graphica (v.1.0.39) was applied to analyze countries/regions, institutions, and published journals.

Results:
We finally included 1000 publications published between 2003 and July 4, 2024. Publications showed an upward trend, with the largest number of publications in 2023. USA is the most published country, Harvard University is the most published institution, Taghian AG is the most published author, and DiSipio T is the most cited author. Lymphatic Research and Biology is the most published journal, and Cancer-American Cancer Society is the most cited journal. “Breast cancer,” “arm lymphedema,” and “quality of life” were the most frequent keywords. Current research focuses on risk factors, treatment strategies, and patients’ quality of life with BCRL. Future research will mainly focus on establishing BCRL evaluation protocols, improving treatment techniques, and early prevention and detection of BCRL.

Conclusion:
Our study sorts out the current knowledge structure in the field and highlights the current state of research and future research directions. These findings inform researchers and clinicians.
Cervical arteries tortuosity and its association with dissection: A systematic review and meta-analysis
Authors: Bitar Anas , Almahder Dana , A. Jouini Jaafer , Alsaid Bayan 
Published: February 2025

Background:
This study investigated the link between arterial tortuosity and cervical artery dissection, focusing on carotid and vertebral tortuosity indices, as well as carotid tortuosity classifications (kinking, looping, and coiling).

Methods:
We searched PubMed, SCOPUS, Web of Science, and Google Scholar from database inception to January 2024. The inclusion criteria encompassed human studies on tortuosity and cervical, carotid, or vertebral artery dissection. Exclusion criteria included case reports, non-English studies, and studies solely on connective tissue disorders and diseases. Quality and risk of bias were assessed using the Newcastle-Ottawa Scale. Random-effects model was employed for mean differences and odds ratios. When meta-analysis was not feasible, we summarized and integrated the results narratively.

Results:
Seven studies, involving 507 dissected patients and 582 non-dissected patients, were included. In a meta-analysis of 3 studies, vertebral tortuosity favored the dissection cases [MD = 3.58, 95% CI: 2.21–4.95]. The mean carotid tortuosity difference was not statistically significant in a meta-analysis of 2 studies [MD = 2.27, 95% CI: −0.16–4.70]. In the classification analysis, 2 studies indicated no conclusive association between kinking, coiling, and cervical arteries dissection. Regarding carotid classification and internal carotid artery dissection, meta-analyses only showed a significant association with kinking, but the result was inconclusive.

Conclusion:
Tortuosity index screenings may help prevent cervical artery dissection among at-risk individuals. However, the association with specific tortuosity classifications remains inconclusive, and further research is needed to validate these findings. Standardized measurement criteria are crucial for future studies.
CO2 and aerosol concentration during manual and mechanical chest compression while cardiopulmonary resuscitation
Authors: Heymer Johannes , Dengler Florian , Hein Anna , Krohn Alexander , Jaki Christina , Echterdiek Fabian , Schmid Stephan , Müller-Schilling Martina , Schilling Tobias , Ott Matthias 
Published: February 2025

Background:
This study investigates the staff-to-staff transmission risk of Coronavirus disease 2019 during cardiopulmonary resuscitation in an ambulance vehicle.

Methods:
Comparing manual and mechanical chest compressions, CO2 concentrations were monitored as a proxy for infection risk.

Results:
Results suggest that mechanical chest compressions generate lower CO2 levels, indicating a reduced risk of infection among healthcare workers compared to manual compressions.

Conclusions:
These findings highlight the potential benefits of employing mechanical chest compressions to mitigate staff-to-staff infections in small, confined spaces during aerosol-transmitted diseases.
Progress and prospects of Parkinson’s disease with depression research: A global bibliometric analysis based on CiteSpace
Authors: Li Jianlin , You Jianhang , Li Zaipu , Zang Jing , Wu Lin , Zhao Tao 
Published: February 2025

Background:
Parkinson’s disease (PD) is a common neurodegenerative disorder marked by motor impairments such as stiffness, involuntary shaking, and slowed movement. In addition, PD patients frequently experience nonmotor symptoms, especially depression. This study uses a mixed-methods scientometric analysis to review global research trends and advancements in PD and depression. This analysis is vital for clinicians, researchers, and policymakers, identifying knowledge gaps and directing future research efforts.

Methods:
We conducted a comprehensive literature review on PD and depression using the Web of Science database from 2004 to 2023, facilitated by CiteSpace 6.1.R6. Our analysis examined collaborations among authors, institutions, countries, and keywords, incorporating insights from RCTs and qualitative studies. We calculated effect sizes and confidence intervals with precision. Ethical approval was not required as the study used publicly available data without personal information.

Results:
Our analysis included 3048 research papers and 915 reviews, involving 17,927 authors and 12,466 institutions. The United States and the University of Toronto led in publications. Studies revealed significant effect sizes with narrow confidence intervals, particularly on the prevalence and impact of depression in PD patients. High-frequency keywords included “Parkinson’s disease,” “depression,” “quality of life,” “non-motor symptom,” and “dementia.” Visual mapping identified critical research nodes and future directions.

Conclusion:
Over the past 2 decades, research on the PD-depression link has accelerated. Our analysis highlights prevailing trends and critical areas, providing evidence-based recommendations for therapeutic strategies. This study offers valuable insights for clinicians and researchers, emphasizing future research priorities to improve patient outcomes.
Safety and efficacy of carbon dioxide laser therapy for vocal cord leukoplakia: A systematic review and meta-analysis
Authors: Liang Jiao , Zhou Yanan , Xu Zhoujie , Cao Xingwei 
Published: February 2025

Background:
Vocal cord leukoplakia is a precancerous lesion for which early surgical intervention following ineffective conservative treatment is the predominant approach. Carbon dioxide (CO2) laser treatment is a novel, minimally invasive therapy. However, there is insufficient evidence to suggest that CO2 laser treatment is superior to conventional surgical methods in terms of efficacy and safety. Therefore, this meta-analysis aimed to evaluate the efficacy and safety of CO2 laser treatment vs conventional surgical treatment for vocal cord leukoplakia.

Methods:
A literature search was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines across 8 databases. Studies on the use of carbon dioxide laser therapy for vocal cord leukoplakia were included in the review. Two researchers conducted a systematic search for randomized controlled trials in PubMed, Embase, Cochrane, Web of Science, China National Knowledge Infrastructure, Wanfang, Chinese Science and Technology Periodical Database, and Chinese Biomedical Literature databases. Meta-analysis was performed using Stata 18.0, and RevMan 5.2 software.

Results:
The findings indicated that Compared with conventional surgery, CO2 laser surgery significantly reduced the recurrence rate of vocal cord leukoplakia (odds ratio [OR] = 0.25, 95% confidence interval, CI [0.12, 0.51]). CO2 laser surgery significantly improved the cure rate of vocal cord leukoplakia (OR = 3.07, 95% CI [1.17, 8.09]). Voice quality following CO2 laser surgery was significantly superior to that following conventional surgery, particularly in terms of fundamental frequency disturbance (standardized mean difference [SMD] = −0.8, 95% CI [−1.25, −0.34]) and amplitude disturbance (SMD = −0.52, 95% CI [−0.95, −0.09]). The CO2 laser group exhibited a lower incidence of postoperative adverse reactions (OR = 0.32, 95% CI [0.03, 3.19]); however, this difference was not statistically significant.

Conclusion:
The results of this meta-analysis suggest that CO2 laser surgery can reduce the recurrence rate of vocal cord leukoplakia, improve the cure rate, and enhance voice quality. Therefore, CO2 laser surgery is recommended as a minimally invasive surgical approach for vocal cord leukoplakia.
Beneficial effects and possible mechanism of intake coffee for COVID-19: A meta-analysis and molecular docking
Authors: Fan Yong-Zheng , Duan Yun-Li , Zhang An-Na , Wang Yu 
Published: February 2025

Background:
To systematically evaluate the effectiveness of regular coffee intake in the prevention or treatment of COVID-19 infection, and to explore its possible mechanism of action using computer molecular docking technology.

Methods:
We searched for relevant ClinicalTrials.gov, Cochrane Library, PubMed, Web of Science, Embase, and China Biomedicine, Wanfang, CNKI, VIP databases to summarize studies on the effectiveness of coffee in preventing or treating COVID-19. The search period lasted until August 1, 2024. The 2 researchers screened the literature and data using Rev Man 5.4 software (the Cochrane Collaboration, 2020) for data analysis and used Schrodinger 2018-1 software to explore possible mechanisms of action.

Results:
A total 5 studies with 39,290 participants were included. The results showed that compared with the control group that drank less or no coffee, the experimental group that drank more than 1 cup of coffee per day had significantly higher benefit rates (RD = 0.17, 95% confidence intervals [CI] = 0.08–0.27, P = .0005), including lower infection rates and improved recovery rates from COVID-19 (RD = 0.24, 95% CI = 0.13–0.35), P < .0001). Molecular docking showed that CGA and caffeine present in coffee could combine with key amino acid residues of ACE2 or 3CL proteins to form hydrogen bonds.

Conclusions:
Regular consumption of coffee may have certain preventive or therapeutic effects on COVID-19, and the mechanism of action may be that CGA or/caffeine in coffee may be related to the formation of hydrogen bonds by key amino acid residues such as ARG273/HIE345 of ACE2 and CYS145 of 3CL. Owing to the limited number and quality of the included studies, the effect evaluation needs to be further confirmed using clinical randomized controlled trials. The exact mechanism of action requires further verification at the molecular level, both inside and outside cells.
Primary cardiac angiosarcoma: A clinical report of 1 case and review of the literature
Authors: Sun Jiubo , Li Jing , Wang Xiaofei , Huo Xiaoguang , Xu Wenzhe , Li Fei 
Published: February 2025

Rationale:
Primary cardiac angiosarcoma is very rare with a poor prognosis, and there is no recognized guideline for its diagnosis and treatment. Currently, there is no standardized adjuvant chemotherapy regimen following radical surgery for cardiac angiosarcoma. To date, the literature lacks reports on the use of albumin-bound paclitaxel as an adjuvant chemotherapy agent in this context. This case report aims to document and evaluate the imaging characteristics of the disease and the efficacy of albumin-bound paclitaxel as adjuvant chemotherapy, thereby providing valuable insights for clinical diagnosis and treatment.

Patient concerns:
We report a 70-year-old patient with right atrial angiosarcoma, who presented with atrial fibrillation as the initial symptom.

Diagnoses:
Transesophageal echocardiography, chest computed tomography, and cardiac magnetic resonance imaging showed a right atrial mass.

Interventions:
After radical resection, the patient was given 4 cycles of albumin-bound paclitaxel adjuvant chemotherapy.

Outcomes:
Multiple metastases occurred in a short period of time, and the patient died 13 months after surgery. Surgical resection is the most important treatment for cardiac angiosarcoma, and the optimal adjuvant therapy needs to be further studied.

Lessons:
The limitation of this case report is its reliance on a single case, resulting in a limited sample size. To comprehensively characterize cardiac angiosarcoma and evaluate the efficacy of albumin-bound paclitaxel chemotherapy, future studies should collect additional cases and conduct long-term follow-up.