bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the diagnostic potential of adding T2 dependence in diffusion-weighted MR imaging of the prostate
Authors: Syversen Ingrid Framås , Elschot Mattijs , Sandsmark Elise , Bertilsson Helena , Bathen Tone Frost , Goa Pål Erik 
Published: May 2021

Background
Magnetic resonance imaging (MRI) is essential in the detection and staging of prostate cancer. However, improved tools to distinguish between low-risk and high-risk cancer are needed in order to select the appropriate treatment.

Purpose
To investigate the diagnostic potential of signal fractions estimated from a two-component model using combined T2- and diffusion-weighted imaging (T2-DWI).

Material and methods
62 patients with prostate cancer and 14 patients with benign prostatic hyperplasia (BPH) underwent combined T2-DWI (TE = 55 and 73 ms, b-values = 50 and 700 s/mm2) following clinical suspicion of cancer, providing a set of 4 measurements per voxel. Cancer was confirmed in post-MRI biopsy, and regions of interest (ROIs) were delineated based on radiology reporting. Signal fractions of the slow component (SFslow) of the proposed two-component model were calculated from a model fit with 2 free parameters, and compared to conventional bi- and mono-exponential apparent diffusion coefficient (ADC) models.

Results
All three models showed a significant difference (p<0.0001) between peripheral zone (PZ) tumor and normal tissue ROIs, but not between non-PZ tumor and BPH ROIs. The area under the receiver operating characteristics curve distinguishing tumor from prostate voxels was 0.956, 0.949 and 0.949 for the two-component, bi-exponential and mono-exponential models, respectively. The corresponding Spearman correlation coefficients between tumor values and Gleason Grade Group were fair (0.370, 0.499 and -0.490), but not significant.

Conclusion
Signal fraction estimates from a two-component model based on combined T2-DWI can differentiate between tumor and normal prostate tissue and show potential for prostate cancer diagnosis. The model performed similarly to conventional diffusion models.
More Money — More Births? Estimating Effects of 2007 Family Policy Changes on Probability of Second and Subsequent Births in Russia
Authors: Бирюкова Светлана Сергеевна , Синявская Оксана Вячеславовна 
Published: May 2021

From 2007 to 2015 total fertility rate in Russia increased from 1.42 to 1.78, following a long period of decline in 1990-1999 and stagnation in 2000-2006. Politicians attribute this growth to a package of pro-natalist policy measures introduced in 2007 and particularly to the maternity (family) capital program, the most well-known innovation of the 2007 reform. Existing studies, although sparse, have not actually proven this point of view clearly yet. This paper aims to reveal whether the pro-natalist measures of 2007 have influenced probability of second and consequent births in Russia. Since in 2007 several family policy measures were introduced simultaneously, and the authors estimate their cumulative effect applying a set of binary logistic regressions on the panel of Russian Generations and Gender Survey data collected in 2004, 2007, and 2011. The study reveals that the probability of second and subsequent births before the introduction of policy measures does not differ significantly from that observed after it. The authors find no effect of 2007 family policy changes on probability of second and consequent births in Russia. The data shows some signs of selective influence of the 2007 policy changes on women with lower human capital and incomes, however, further studies on bigger samples are needed to prove this fact. The study extends the academic discussion and adds to the pool of empirical evidence on the pro-natalist policy effects on fertility. By demonstrating no significant effects of Russian 2007 family policy measures the paper contributes to the overcoming of existing publication bias in the field.
Acknowledgements. The authors are grateful for the support granted to the research within the Basic Research Program at the National Research University Higher School of Economics (HSE).
Effects of mechanical vibration on designed steel-based plate geometries: behavioral estimation subjected to applied material classes using finite-element method
Authors: Lenggana Bhre Wangsa , Prabowo Aditya Rio , Ubaidillah Ubaidillah , Imaduddin Fitrian , Surojo Eko , Nubli Haris , Adiputra Ristiyanto 
Published: May 2021

Abstract
A research subject in structural engineering is the problem of vibration under a loading object. The two-dimensional (2D) model of a structure under loading is an example. In general, this case uses an object that is given a random frequency, which then causes various changes in shape depending on the frequency model. To determine the difference in performance by looking at the different forms of each mode, modal analysis with ANSYS was used. The samples to be simulated were metal plates with three variations of the model, namely, a virgin metal plate without any holes or stiffness, plates with given holes, and metal plates with stiffness on one side. The model was simulated with modal analysis, so that 20 natural frequencies were recorded. The sample also used different materials: low-carbon steel materials (AISI 304), marine materials (AISI 1090), and ice-class materials (AR 235). Several random-frequency models proved the deformation of different objects. Variations of sheet-metal designs were applied, such as pure sheet metal, giving holes to the sides, and stiffening the simulated metal sheet.
On the equivalence between weak BMO and the space of derivatives of the Zygmund class
Authors: Kwessi Eddy 
Published: May 2021

Abstract
In this paper, we will discuss the space of functions of weak bounded mean oscillation. In particular, we will show that this space is the dual space of the special atom space, whose dual space was already known to be the space of derivative of functions (in the sense of distribution) belonging to the Zygmund class of functions. We show, in particular, that this proves that the Hardy space

H

1

{H}^{1}

strictly contains the special atom space.
Spatiotemporal variation in groundwater level within the Manas River Basin, Northwest China: Relative impacts of natural and human factors
Authors: Wu Yage , Yang Guang , Tian Lijun , Gu Xinchen , Li Xiaolong , He Xinlin , Xue Lianqing , Li Pengfei , Xiao Senyuan 
Published: May 2021

Abstract
The Manas River Basin (MRB), Northwest China, is an arid basin dependent on irrigation for agriculture, and human activities are believed to be the primary factor affecting the groundwater level fluctuations in this basin. Such fluctuations can have a significant adverse impact on the social economy, agricultural development, and natural environment of that region. This raises concerns regarding the sustainability of groundwater use. In this study, we used ArcGIS spatial interpolation and contrast coefficient variance analysis to analyse groundwater level, land-use change, and water resource consumption patterns from 2012 to 2019 in the plains of the MRB. The aim was to determine the main factors influencing the groundwater level and to provide a scientific basis for the rational development, utilisation, and management of water resources in this area. During the study period, the groundwater level decreased, increased, and then fluctuated with a gradually slowing downward trend; the decline ranged from −17.82 to −11.67 m during 2012–2019. Within a given year, groundwater levels declined from March/April to August/September, then rose from August/September to March/April, within a range of 0.29–19.05 m. Primary factors influencing the groundwater level included human activities (e.g., changes in land use, river regulation, irrigation, and groundwater exploitation) and natural causes (e.g., climate and weather anomalies). Human activities were the primary factors affecting groundwater level, especially land-use change and water resource consumption. These results provide a theoretical basis for the rational exploitation of groundwater and the optimisation of water resource management in this region.
Evaluation of the mixing quality of high-viscosity yield stress fluids in a tubular reactor
Authors: Xie Le , He Guangwen , Yu Bin , Yan Shaowei 
Published: May 2021

Abstract
In this study, the mixing quality of high-viscosity yield stress fluid (Carbopol aqueous solution) under laminar and turbulent flow regimes was evaluated through a numerical experimental study. A three-dimensional computational fluid dynamics large-eddy simulation (CFD-LES) model was employed to capture large-scale vortex structures. The proposed CFD model was validated by the experimental data in terms of mean velocity profiles and velocity-time history. Thereafter, the CFD model was applied to simulate the residence time distribution using the tracking technique: tracer pulse method and step method. In addition, the non-ideal flow phenomena caused by molecular diffusion and eddy diffusion were evaluated. The effects of the rheological properties on the mixing performance were also investigated. The presented results can provide useful guidance to enhance mass transfer in reactors with high-viscosity fluids.
Comparison between flexible AC transmission systems (FACTs) and filters regarding renewable energy systems harmonics mitigation
Authors: Hamdy Mohamed , Abdelaziz Almoataz Y. , Ray Papia , Attia Mahmoud A. 
Published: May 2021

AbstractRenewable energy growing is considered one of the main sources of the system harmonics. Thus, in this paper, Total Harmonic Distortion (THD) is reduced by using flexible AC transmission systems (FACTs). Static Compensator (STATCOM) and Static Synchronous Series Compensator (SSSC) are used and compared against basic harmonics filter. Cases studied are as follows: First, the system is studied without any harmonic limitation. Then each type of the chosen two types of (FACTs) is connected to the system. Finally, the harmonics filter is used as a reference to verify the (FACTs) effectiveness. MATLAB/SIMULINK is the tool to examine and simulate the system.
A fundamental measure of treatment effect heterogeneity
Authors: Levy Jonathan , van der Laan Mark , Hubbard Alan , Pirracchio Romain 
Published: May 2021

Abstract
The stratum-specific treatment effect function is a random variable giving the average treatment effect (ATE) for a randomly drawn stratum of potential confounders a clinician may use to assign treatment. In addition to the ATE, the variance of the stratum-specific treatment effect function is fundamental in determining the heterogeneity of treatment effect values. We offer a non-parametric plug-in estimator, the targeted maximum likelihood estimator (TMLE) and the cross-validated TMLE (CV-TMLE), to simultaneously estimate both the average and variance of the stratum-specific treatment effect function. The CV-TMLE is preferable because it guarantees asymptotic efficiency under two conditions without needing entropy conditions on the initial fits of the outcome model and treatment mechanism, as required by TMLE. Particularly, in circumstances where data adaptive fitting methods are very important to eliminate bias but hold no guarantee of satisfying the entropy condition, we show that the CV-TMLE sampling distributions maintain normality with a lower mean squared error than TMLE. In addition to verifying the theoretical properties of TMLE and CV-TMLE through simulations, we highlight some of the challenges in estimating the variance of the treatment effect, which lack double robustness and might be biased if the true variance is small and sample size insufficient.
Sino-Japanese Interaction via Chinese Junks in the Edo Period
Authors: Akira Matsuura 
Published: May 2021

Abstract
To maintain its policy of national isolation during the Edo period, Japan restricted contact with the outside world to Dutch merchant ships and Chinese junks at the Japanese port of Nagasaki. Sino-Japanese interaction consisted not only of trade in goods, but also of cultural and scholarly exchanges. This paper will examine how this unofficial trade affected both Japan and China from a cultural perspective.
One-pot solvothermal synthesis and characterization of highly stable nickel nanoparticles
Authors: Jaji Nuru-Deen , Othman Muhammad Bisyrul Hafi , Lee Hooi Ling , Hussin Mohd Hazwan , Hui David 
Published: May 2021

Abstract
High stable nickel nanoparticles (NiNPs) have been successfully synthesized from nickel chloride as the precursor through a simple one-pot solvothermal process. A systematic investigation of the reaction parameters, namely, effects of reaction temperature, pH of precursor solution, the concentration of reactants, and reaction time on the formation of NiNPs, was carried out to obtain the optimal values for the synthesis. The optimum reaction temperature, pH, NiCl2·6H2O concentration, and reaction time are 190°C, pH 9, 0.1 M, and 24 h. The characteristic peaks of NiNPs have been confirmed by the Fourier transformer infra-red and surface plasmon resonance, with the presence of –OH stretching bands at 3,593 and 603 cm−1 (interaction with Ni and NiO) and λ
max 265 nm, respectively. The X-ray diffraction and transmission electron microscope demonstrated the particle size of about 24 nm (by Scherrer) and 49 nm (Image-J), respectively, with the face center cubic phase. The synthesized NiNPs showed good stability, where the degradation of NiNPs was completed at 800°C with more than 97% residue as depicted by the thermogravimetry analysis. The synthesized NiNPs can be used as fillers to enhance the thermal, mechanical, and electrical properties of polymeric materials.
Vapor bubble induced electric current generation
Authors: Li Wenzhuo , Zhang Wanying , Zhou Lingye , Shen Qingchen , Jiang Modi , Fu Benwei , Tao Peng , Song Chengyi , Wu Jianbo , Deng Tao , Shang Wen 
Published: May 2021

Abstract
Contact electrification (CE) has been utilized in various energy conversion systems in recent years. This work presents a constant electric energy output that was generated based on the CE at the water–metal interface. When a grounded Pt mesh is placed in water that is heated to boil, a continuous flow of electrons between the Pt mesh and the ground is generated. A possible mechanism for the generation of such electric current is based on the CE between the surface of the Pt mesh and water molecules. The local high-pressure thin liquid film regions between vapor bubbles and surface of Pt mesh promote this CE process. The constant water evaporation and bubble detachment enable the continuous electric current output. In this work, the impact of the heating temperature and the bias voltages on the generation of the current was also studied. This work provides an alternative approach to generate unidirectional current on the basis of CE at the water–metal interface, and it also offers new insights in the design of CE-based systems for the generation of electricity.
Nervonic acid amends motor disorder in a mouse model of Parkinson’s disease
Authors: Hu Dandong , Cui Yujuan , Zhang Ji 
Published: May 2021

Abstract

Objectives
Parkinson’s disease (PD) is a kind of common neurodegenerative disease in the world. Previous studies have proved that nervonic acid (NA), extracted from Xanthoceras sorbifolia Bunge, has the potentials of neuroprotection. However, the effect of NA on the PD remained unknown. This study was designed to investigate the NA’s potential function and relative mechanism on motor disorder.

Methods
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was used for producing parkinsonism motor disorder on male C57BL/6 mice. Toxicity experiments and behavioral assay were performed to evaluate the effect of NA. Besides, the expression levels of tyrosine hydroxylase and α-synuclein, as well as striatal dopamine (DA), serotonin, and their metabolites were explored through immunoblotting and chromatography after NA treatment in vivo.

Results
We found that NA could alleviate the MPTP-induced behavioral deficits dose-dependently. Moreover, NA has no toxic effects on the mouse liver and kidney. Of note, we found that NA significantly reduced the impact of MPTP impairment and striatal DA, serotonin, and metabolites were remained unaffected. In addition, tyrosine hydroxylase was upregulated while α-synuclein being downregulated and the oxidative stress was partially repressed evidenced by the upregulation of superoxide dismutase and glutathione activity after NA treatment.

Conclusion
Our findings unveil NA’s potential for protecting motor system against motor disorder in the PD mouse model without any side effects, indicating NA as an alternative strategy for PD symptom remission.
One-pot synthesis of 1-(benzothiazolylamino)aryl methyl-2-naphthols and 3-benzothiazolyl 2,3-dihydroquinazolinones using a magnetically recoverable core–shell nanocomposite as catalyst
Authors: Mardani Yousef , Karimi-Jaberi Zahed , Soltanian Fard Mohammad Jaafar 
Published: May 2021

Abstract
Nano-magnetite-supported sulfated polyethylene glycol (Fe3O4@PEG-SO3H) was prepared, characterized and utilized as a magnetically recoverable heterogeneous catalyst for the one-pot, three-component reaction of 2-aminobenzothiazole, aldehydes and 2-naphthol/isatoic anhydride resulting in efficient formation of 1-(benzothiazolylamino)arylmethyl-2-naphthol or dihydroquinazolinones derivatives. The significant features of this method include green conditions, operational simplicity, minimizing production of chemical waste, shorter reaction times and good to high yields. In addition, the nanocatalyst can easily be separated from the reaction mixture by application of a magnetic field and reused without significant deterioration in its catalytic activity.
Features of the installation of a suprapubic cystostomy for laparoscopic treatment of patients with intraperitoneal bladder rupture
Authors: Shanava Gocha S. , Soroka Igor V. , Mosoyan Michail S. 
Published: May 2021

INTRODUCTION: In closed intraperitoneal bladder trauma, an alternative to laparotomy is laparoscopy. The rupture is closed with endoscopic sutures, and the bladder is drained with a urethral catheter. In the literature, the issue of the placement of a trocar cystostomy during laparoscopic treatment of patients with intraperitoneal bladder ruptures requiring prolonged drainage is insufficiently covered.
PURPOSE OF THE STUDY: Determination of the optimal trocar cystostomy method during laparoscopic treatment of intraperitoneal bladder rupture.
MATERIALS AND METHODS: Trocar cystostomy was performed in 8 patients with intraperitoneal bladder ruptures, among whom 7 had concomitant diseases of the prostate gland, and 1 had urethral stricture. Trocar cystostomy during laparoscopic surgery was performed in three different ways. Results. In the first method, the rupture of the bladder was initially sutured. Then, through the urethral catheter, the bladder was filled with saline. A trocar cystostomy was inserted through the suprapubic region. The second method consisted in the installation of a trocar cystostomy under the control of a laparoscope even before the suturing of the bladder rupture. In the third method proposed by us (patent No. 2592023), a Foley-type catheter with a balloon capacity of at least 200 ml was inserted into the abdominal cavity through the laparoscopic port. A catheter was inserted from the abdomen through an intraperitoneal rupture into the bladder. Inside the bladder, the catheter balloon was filled with saline. Then, through the suprapubic region, the anterior abdominal wall, the bladder and the inflated balloon of the catheter were pierced layer by layer with a trocar. Another catheter was inserted through the trocar into the bladder. After removal of the catheter with a ruptured balloon, the intraperitoneal rupture of the bladder was sutured.
FINDINGS: According to the results of the study, the third method of inserting a trocar cystostomy turned out to be the most optimal and safe.
PROM and it’s maternal outcome: a retrospective study in a rural medical college of India
Authors: Sarkar Malay , Mondal Tanushree , Sarkar Manojit 
Published: May 2021

Background: Premature rupture of membrane is the unconstrained break of layer before the beginning of labor and can happen any gestational age even at 42 weeks of growth. Around 2-30 % of all pregnancy will encounter PROM and prompts 33% of preterm birth. The analysis of PROM is to a great extent clinical and is normally proposed by a history of watery vaginal discharge and affirmed on sterile speculum assessment. This examination was led to decide the occurrence, to discover the age, equality dispersion, gestational age dissemination, presentation of PROM and plan the line of the management.Methods: The cases selected in this study were those who had spontaneous rupture of membrane after 28 weeks of gestation but before the onset of labor pain. The study period was of one year from 1st January 2019 to 31st December 2019. The study was conducted in the labor room complex of Coochbehar Govt. Medical College and Hospital, WB India. The patients were admitted in the labor room through emergency. All datas were collected from labor room log book.Results: Total no. of deliveries were 10900 and total no of PROM were 545.Incidence of PROM is 5% in the present study. Maximum no of cases were in the age group between 20-29yr (63%). PROM mainly occurs in primigravida (50.45%). And low rupture of membrane was 91.8%. Cephalic is the commonest presentation (85%) in PROM and the incidence of caesarean section is 24.95%.Conclusions: PROM is the obstetric emergency and once the PROM is diagnosed it is important to weigh the risk of PROM and prematurity and make the right choice of conservative management and active management. If there is chance of maternal morbidity pregnancy should be terminated considering the maternal wellbeing first and then that of the fetus.
Advanced leiomyosarcoma of the uterus: a case report and literature review
Authors: Ottun Tawaqualit A. , Kuye Taiwo O. , Adegboyega Olukayode A. , Olalere Folasade D. H. , Akinbami Omobolanle , Oduyoye Oladunni Yusuf , Salami Morenikeji M. , Rabiu Kabiru , Adewunmi Adeniyi A. 
Published: May 2021

Uterine leiomyosarcoma is a rare malignancy accounting for 1-2% of uterine malignancies with an annual incidence of 0.5-7 per 100,000 women. It occurs mostly between the 5th to 7th decades of life hence found more among postmenopausal women. The aetiology is mostly unknown however, in 0.2% of cases, it originates from sarcomatous degeneration in a pre-existing benign uterine fibroid. Leiomyosarcoma can be mistaken for uterine leiomyoma also known as the uterine fibroid. It is an aggressive tumour that has a poor prognosis, with or without treatment. This case report aimed to report and discuss the occurrence of leiomyosarcoma as a differential diagnosis of abnormal uterine bleeding in this environment among other conditions. This will bring to the fore awareness among gynaecologists, pathologists, radiologists and oncologists that leiomyosarcoma of the uterus, though rare, should be considered in cases of menorrhagia with suspected uterine fibroid to avoid mistaking it for a diagnosis of uterine fibroid/leiomyoma. It is, therefore, imperative to consider leiomyosarcoma in a pre-menopausal and perimenopausal women diagnosed of abnormal uterine bleeding with symptomatic uterine fibroid. MRI serves as a good tool in differentiating the two pathologies.