bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of the peripheral vitreous after vitreous shaving using intraoperative optical coherence tomography
Authors: Nishitsuka Koichi , Nishi Katsuhiro , Namba Hiroyuki , Kaneko Yutaka , Yamashita Hidetoshi 
Published: February 2021

ObjectiveTo evaluate the technique of peripheral vitreous shaving during vitrectomy, we measured the residual peripheral vitreous using intraoperative optical coherence tomography (iOCT).Methods and AnalysisThis retrospective study included 44 eyes that underwent 25-gauge pars plana vitrectomy with iOCT by a single surgeon. In all cases, the surgery was performed via ocular indentation. Cases in group A were treated with vitreous shaving under slit lamp microscope illumination, whereas cases in group B were treated with vitreous shaving under a wide-angle viewing system. Residual peripheral posterior vitreous-cortex detachment (PVD) was quantified by iOCT.ResultsiOCT image analysis enabled the visualisation of the angle formed between the retina and peripheral PVD around the vitreous base in all cases. After the completion of vitreous shaving, the mean length of the peripheral PVD was shorter in group A (961.7±214.7 µm) compared with group B (1925.3.7 ± 626.1 µm; p<0.01).ConclusioniOCT enabled the quantification of the residual peripheral vitreous after vitreous shaving. The quantification of the residual peripheral vitreous after different shaving procedures will be important for advocating appropriate vitreous shaving in future.
Comparative effectiveness of oral anticoagulants in everyday practice
Authors: Camm A John , Fox Keith A A , Virdone Saverio , Bassand Jean-Pierre , Fitzmaurice David A , Berchuck Samuel I , Gersh Bernard J , Goldhaber Samuel Z , Goto Shinya , Haas Sylvia , Misselwitz Frank , Pieper Karen S , Turpie Alexander G G , Verheugt Freek W A , Cappato Riccardo , Kakkar Ajay K 
Published: February 2021

ObjectivesThis study evaluated the comparative effectiveness of vitamin K antagonists (VKAs), direct thrombin inhibitors (DTIs) and factor Xa inhibitors (FXaI) in patients with atrial fibrillation (AF) at risk of stroke in everyday practice.MethodsData from patients with AF and Congestive heart failure, Hypertension, Age 75 years, Diabetes mellitus, prior Stroke, TIA, or thromboembolism, Vascular disease, Age 65-74 years, Sex category (CHA2DS2-VASc) score ≥2 (excluding gender) in the Global Anticoagulant Registry in the FIELD–Atrial Fibrillation registry were analysed using an improved method of propensity weighting, overlap weights and Cox proportional hazards models.ResultsAll-cause mortality, non-haemorrhagic stroke/systemic embolism (SE) and major bleeding over 2 years were compared in 25 551 patients, 7162 (28.0%) not treated with oral anticoagulant (OAC) and 18 389 (72.0%) treated with OAC (FXaI (41.8%), DTI (11.4%) and VKA (46.8%)). OAC treatment compared with no OAC treatment was associated with decreased risk of all-cause mortality (HR 0.82 (95% CI 0.74 to 0.91)) and non-haemorrhagic stroke/SE (HR 0.71 (95% CI 0.57 to 0.88)) but increased risk of major bleeding (HR 1.46 (95% CI 1.15 to 1.86)). Non-vitamin K antagonist oral anticoagulant (NOAC) use compared with no OAC treatment was associated with lower risks of all-cause mortality and non-haemorrhagic stroke/SE (HR 0.67 (95% CI 0.59 to 0.77)) and 0.65 (95% CI 0.50 to 0.86)) respectively, with no increase in major bleeding (HR 1.10 (95% CI 0.82 to 1.47)). NOAC use compared with VKA use was associated with lower risk of all-cause mortality and major bleeding (rates/100 patient-years 3.6 (95% CI 3.3 to 3.9) vs 4.8 (95% CI 4.5 to 5.2) and 1.0 (95% CI 0.9 to 1.1) vs 1.4 (95% CI 1.2 to 1.6); HR 0.79 (95% CI 0.70 to 0.89) and 0.77 (95% CI 0.61 to 0.98) respectively), with similar risk of non-haemorrhagic stroke/SE (rates/100 patient-years 0.8 (95% CI 0.7 to 0.9) versus 1.0 (95% CI 0.8 to 1.1); HR 0.96 (95% CI 0.73 to 1.25).ConclusionImportant benefits in terms of mortality and major bleeding were observed with NOAC versus VKA with no difference among NOAC subtypes.Trial registration numberNCT01090362.
How individual ethical frameworks shape physician trainees’ experiences providing end-of-life care: a qualitative study
Authors: Rosenwohl-Mack Sarah , Dohan Daniel , Matthews Thea , Batten Jason Neil , Dzeng Elizabeth 
Published: February 2021

ObjectivesThe end of life is an ethically challenging time requiring complex decision-making. This study describes ethical frameworks among physician trainees, explores how these frameworks manifest and relates these frameworks to experiences delivering end-of-life care.DesignWe conducted semistructured in-depth exploratory qualitative interviews with physician trainees about experiences of end-of-life care and moral distress. We analysed the interviews using thematic analysis.SettingAcademic teaching hospitals in the United States and United Kingdom.ParticipantsWe interviewed 30 physician trainees. We purposefully sampled across three domains we expected to be associated with individual ethics (stage of training, gender and national healthcare context) in order to elicit a diversity of ethical and experiential perspectives.ResultsSome trainees subscribed to a best interest ethical framework, characterised by offering recommendations consistent with the patient’s goals and values, presenting only medically appropriate choices and supporting shared decision-making between the patient/family and medical team. Others endorsed an autonomy framework, characterised by presenting all technologically feasible choices, refraining from offering recommendations and prioritising the voice of patient/family as the decision-maker.ConclusionsThis study describes how physician trainees conceptualise their roles as being rooted in an autonomy or best interest framework. Physician trainees have limited clinical experience and decision-making autonomy and may have ethical frameworks that are dynamic and potentially highly influenced by experiences providing end-of-life care. A better understanding of how individual physicians’ ethical frameworks influences the care they give provides opportunities to improve patient communication and advance the role of shared decision-making to ensure goal-aligned end-of-life care.
Intrinsic hospital factors: overlooked cause for variations in delay to transfer for endovascular thrombectomy
Authors: Danziger Ron , Tan Christina , Churilov Leonid , Mitchell Peter , Dowling Richard , Bush Steven , Yan Bernard 
Published: February 2021

BackgroundIntrinsic hospital factors leading to time delay to inter-hospital transfer for endovascular thrombectomy (EVT) have not been adequately investigated, leading to uncertainty in generalizability of hub and spoke EVT services. We investigated the contribution of intrinsic hospital factors to variations in time delay in a multicenter, retrospective study.MethodsThe setting was a hub and spoke EVT state-wide system for a population of 6.3 million and 34 spoke hospitals. We collected data on acute large vessel occlusion strokes transferred from spoke to hub for consideration of EVT between January 2016 and December 2018. The primary endpoint was the proportion of variability in delay-time in transfer cases contributed to by intrinsic hospital factors estimated through variance component analysis implemented as a mixed-effect linear regression model with hospitals as random effects.ResultsWe included 434 patients. The median age was 72 years (IQR 62–79), 44% were female, and the median baseline National Institutes of Health Stroke Scale (NIHSS) was 16 (IQR 11–20). The median onset to CT time was 100 mins (IQR 69–157) at the spoke hospitals and CT acquisition at the spoke hospital to time of transfer was 93 min (IQR 70–132). 53% of the observed variability in time from CT acquisition at the spoke hospital to transfer to the EVT center was explained by intrinsic hospital factors, as opposed to patient-related factors.ConclusionsIntrinsic hospital factors explained more than half of the observed variability in time from CT acquisition at the spoke hospital to departure for transfer. We recommend that the design of hub and spoke EVT services should account for intrinsic hospital factors to minimize hospital transfer delay.
Upper extremity transvenous access for neuroendovascular procedures: an international multicenter case series
Authors: Abecassis Isaac Josh , Saini Vasu , Phillips Timothy John , Osbun Joshua W , Martínez-Galdámez Mario , Nada Ahmed , Levitt Michael R , Crowley R Webster , Sattur Mithun G , Spiotta Alejandro M , Luther Evan , Chen Stephanie H , Burks Joshua , Jabbour Pascal , Sweid Ahmad , Psychogios Marios N , Park Min S , Yavagal Dileep R , Peterson Eric C , Waqas Muhammad , Dossani Rimal Hanif , Davies Jason M , Brehm Alex , Selkirk Gregory D , Fox W Christopher , Abud Daniel Giansante , Galvan Fernandez Jorge , Schüller Arteaga Miguel , Starke Robert M 
Published: February 2021

BackgroundRadial artery access for transarterial procedures has gained recent traction in neurointerventional due to decreased patient morbidity, technical feasibility, and improved patient satisfaction. Upper extremity transvenous access (UETV) has recently emerged as an alternative strategy for the neurointerventionalist, but data are limited. Our objective was to quantify the use of UETV access in neurointerventions and to measure failure and complication rates.MethodsAn international multicenter retrospective review of medical records for patients undergoing UETV neurointerventions or diagnostic procedures was performed. We also present our institutional protocol for obtaining UETV and review the existing literature.ResultsOne hundred and thirteen patients underwent a total of 147 attempted UETV procedures at 13 centers. The most common site of entry was the right basilic vein. There were 21 repeat puncture events into the same vein following the primary diagnostic procedure for secondary interventional procedures without difficulty. There were two minor complications (1.4%) and five failures (ie, conversion to femoral vein access) (3.4%).ConclusionsUETV is safe and technically feasible for diagnostic and neurointerventional procedures. Further studies are needed to determine the benefit over alternative venous access sites and the effect on patient satisfaction.
Comparing how Canadian packaged food products align with the 2007 and 2019 versions of Canada’s Food Guide
Authors: Mulligan Christine , Franco-Arellano Beatriz , Ahmed Mavra , Vergeer Laura , Dickinson Kacie , L’Abbé Mary R. 
Published: February 2021

In 2019, Canada’s Food Guide (CFG) was updated from the 2007 version. This study developed a food-based nutrient profile model (NPM) to evaluate the alignment of packaged food and beverage products with CFG 2019 and compared it with CFG 2007. Packaged products from the University of Toronto’s Food Label Information Program 2017 database were evaluated in terms of their alignment with CFG 2007 (using the Health Canada Surveillance Tool (HCST)) and CFG 2019 (using our newly developed CFG 2019 NPM). Agreement in alignment (e.g., products “in line” according to CFG 2019 NPM and in Tiers 1 or 2 according to the HCST) was calculated and differences in alignment and reasons for differences were quantified and described. Overall agreement in product alignment between CFG 2007 and 2019 was 81.9%, with fewer products aligned with CFG 2019: 16.4% vs. 31.8%, (χ2 = 189.12, p < 0.001). Differences in alignment varied across food categories (0.0–73.8%), explained by differences in CFG 2019, reflected in the CFG 2019 NPM (e.g., emphasis on avoiding processed foods, encouraging whole grains and low-fat dairy). This study presents a first step in assessing packaged foods’ alignment with CFG 2019; future work is needed to evaluate broader dietary adherence to the updated recommendations. Novelty: A food-based nutrient profile model was developed based on the 2019 CFG and tested on packaged foods by comparing it with the nutrient-based HCST, based on CFG 2007. Most (82%) packaged products were “not in line” with either CFG version.
The acute and postprandial effects of sugar moiety on vascular and metabolic health outcomes in adolescents
Authors: Koep Jodie L. , Barker Alan R. , Banks Rhys , Banger Rohit R. , Lester Alice , Sansum Kate M. , Weston Max E. , Bond Bert 
Published: February 2021

This study explored the cardiometabolic responses to sugar moieties acutely, and following a subsequent mixed meal tolerance test (MMTT). Twenty-one healthy adolescents (N = 10 female, 14.3 ± 0.4 years) completed 3 experimental and 1 control condition, in a counterbalanced order. These consisted of different drinks to compare the effect of 300 mL of water (control), or 300 mL of water mixed with 60 g of glucose, fructose or sucrose, on vascular function (flow-mediated dilation (FMD), microvascular reactivity (total hyperaemic response; TRH), and cerebrovascular reactivity (CVR)), and blood samples for uric acid, glucose, triglycerides and lactate concentrations. FMD increased 1 h after glucose and sucrose (P < 0.001, ES ≥ 0.92) but was unchanged following fructose and water (P ≥ 0.19, ES ≥ 0.09). CVR and TRH were unchanged 1 h following all conditions (P > 0.57, effect size (ES) > 0.02). Following the MMTT, FMD was impaired in all conditions (P < 0.001, ES > 0.40) with no differences between conditions (P > 0.13, ES < 0.39). Microvascular TRH was increased in all conditions (P = 0.001, ES = 0.88), and CVR was preserved in all conditions after MMTT (P = 0.87, ES = 0.02). Blood uric acid concentration was elevated following fructose consumption and the MMTT (P < 0.01, ES > 0.40). Consumption of a sugar sweetened beverage did not result in vascular dysfunction in healthy adolescents; however, the vascular and metabolic responses were dependent on sugar moiety. Novelty: Glucose consumption acutely increases peripheral vascular function in healthy adolescents. Acute sugar sweetened beverage consumption (sucrose) does not result in adverse vascular outcomes. Elevations in uric acid are observed with fructose consumption, which may have implications over repeated exposure.
Evaluation of a combination of phosphorylated fibers and zeolite as a potential substitute to synthetic wetting agents in peat moss products
Authors: Mouandhoime Zahahe Oulame , Brouillette François 
Published: February 2021

Water availability and pH are important factors to consider to determine the suitability of a material for use as a growing medium. Unfortunately, most horticultural substrates are characterized by their water repellency. This is the case with peat moss which is hydrophobic and acidic. Synthetic surfactants are required to improve its wettability. In this study, a combination of phosphorylated wood pulp fibers (FLP) and zeolite is proposed as a substitute to surfactants to increase the wettability of peat moss in the presence of lime, an additive generally used as fertilizer or pH regulator. Results show that lime reduces the water retention capacity of FLP. However, the addition of 15% zeolite to the peat moss/FLP system increases the pH and water retention of the substrate. The negative effect of the presence of 1 wt. % lime on the water retention of the peat moss/FLP mixture was corrected by zeolite addition. Optimal conditions were obtained at 10% zeolite for the two types of lime tested with favorable pH and water retention capacity values. Zeolite was shown to have a higher affinity than FLP for calcium ions preventing the detrimental interaction between FLP and calcium ions.
Production cross-section calculations of 111In via proton and alpha-induced nuclear reactions
Authors: Özdoğan H. , Sarpün İsmail Hakki , Şekerci Mert , Kaplan Abdullah 
Published: February 2021

[Formula: see text], a known gamma emitter, is used for many medical purposes such as imaging of myocardial metastases. It can be produced by using different nuclear reactions. In this study, the reactions of [Formula: see text]Ag([Formula: see text]2n)[Formula: see text], [Formula: see text](p,[Formula: see text]n)[Formula: see text], [Formula: see text](p,[Formula: see text]2n)[Formula: see text], [Formula: see text](p,[Formula: see text]3n)[Formula: see text] and [Formula: see text](p,[Formula: see text]4n)[Formula: see text], which are the production routes of [Formula: see text], were investigated. Production cross-section calculations were performed by using equilibrium and pre-equilibrium models of TALYS 1.95 and EMPIRE 3.2 nuclear reaction codes. Hauser–Feshbach Model was appointed in both codes for calculations of equilibrium approximations. Exciton and Hybrid Monte Carlo Simulation (HMS) models were used in the EMPIRE 3.2, whereas Two-Component Exciton and Geometry Dependent Hybrid Model, which is implemented to TALYS code, has been used in the TALYS 1.95 for pre-equilibrium reactions. Also, a weighting matrix of the nuclear models was obtained by using statistical variance analysis. The optimum beam energy to obtain [Formula: see text] has been determined by using the results obtained from this weighting matrix.
First record of Rocinela aff. australis (Isopoda, Aegidae) in the Patagonian toothfish Dissostichus eleginoides (Pisces, Nothotenidae) from southern Chile
Authors: Fernández Italo , De los Ríos-Escalante Patricio , Retamal Marco A. , Valenzuela Ariel , Oyarzún Ciro , Campos Víctor 
Published: February 2021

Abstract
An isopod of the family Aegidae, provisionally referred to as Rocinela aff. australis Schiœdte & Meinert, 1879, is reported from the Patagonian tootfish Dissostichus eleginoides Smitt, 1898, from off the Biobio region, Chile. One specimen was collected, its body suboval, symmetrical, the dorsum weakly vaulted, stout, and with a few pits on the body. The specimen collected clearly belongs to the genus Rocinela and within that genus would most closely resemble Rocinela australis, but its actual specific status, whether an established species of the genus (and if so, which one) or possibly proving to be an as yet undescribed species, will have to await close examination by a specialist in marine isopod taxonomy. For the time being, we refer to the specimen as “Rocinela aff. australis”, since, compared with existing Rocinela spp., it matches best with that species both in general morphology and in geographical occurrence. This species, then, was reported until now only for the Strait of Magellan, Magellan region, and the southern Argentinean Atlantic coast. Thus, if the specimen would prove to really belong to Rocinela australis, then this report would constitute the most northern record of that species.
Molecular cloning, tissue distribution and gene expression in response to nutritional regulation of sterol regulatory element binding protein-1 from the swimming crab Portunus trituberculatus (Miers, 1876) (Decapoda, Portunidae)
Authors: Hu Xiaoying , Shi Bo , Jin Min , Wang Xuexi , Yuan Ye , Luo Jiaxiang , Zhou Qicun 
Published: February 2021

Abstract
The sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors known to activate the transcription of genes encoding key lipogenic enzymes. The present study reports on the molecular cloning, tissue expression and nutritional regulation of SREBP-1 from the swimming crab Portunus trituberculatus (Miers, 1876). The SREBP-1 full-length cDNA was 3785 bp, encoding a polypeptide of 1039 amino acids. Quantitative PCR analysis revealed that SREBP-1 expression was detected in various tissues, and the significantly higher expression levels were found in eyestalk and hepatopancreas compared with other tested tissues. Additionally, the effects of dietary iron on expression of SREBP-1 were investigated, and the results indicated that SREBP-1 expressions were down-regulated by crabs fed diets containing 218.9 and 373.9 mg/kg iron compared with that fed the basal diet (55.2 mg/kg). Suggesting that the relative expression level of SREBP-1 can be suppressed by dietary iron supplementation. These findings provide further insight into the regulatory capacity of SREBP-1 in the lipid anabolism of P. trituberculatus.
A Restorative Response to Victims in Proceedings before the International Criminal Court: Reality or Chimaera?
Authors: Cuppini Alessandra 
Published: February 2021

Abstract
The integration of the framework of victims’ participation into the legal proceeding of the International Criminal Court (icc) has been seen as a transformation of the icc process beyond narrow retribution to better accommodate restorative justice (rj) values and practices. However, there is little research into whether, or how the icc metes out rj. This article argues that rj principles brought within icc emphasise the growing importance that victims’ participation in proceedings plays in achieving justice for victims. It then examines how the icc process aligns to the key elements of rj practice, namely victim-offender meeting; offender’s acknowledgement of responsibility and apology; collaborative conflict-resolution approach; victims’ healing and reconciliation; symbolic reparation and material restitution. This article demonstrates that these elements, developed to address ordinary juvenile criminality, are not structured to operate in the particular context of the icc, characterised by grave harm caused to victims and communities by mass atrocity.
A Socio-Historical Perspective on the Amazigh (Berber) Cultural Movement in North Africa
Authors: El Aissati Abderrahman 
Published: February 2021

A socio-historical perspective on the Amazigh (Berber) Cultural Movement in North Africa
North Africa has known various colonizations which in contact with indigenous ones have given the area a special character. One continuing presence since antiquity is that of the Berbers, or the Imazighen, the indigenous population of the area. In this article an attempt is made to shed light on the status of the language and culture of the Imazighen, and in particular on the recent calls for official recognition of the Amazigh language in the constitutions of the two countries with the highest presence of Imazighen, namely Morocco and Algeria. Although some recent developments, like the teaching of the Amazigh language in primary schools, give reason enough to be optimistic about the future of the indigenous language and culture, a closer look at the ideological background of pan Arab-nationalists casts doubts on any serious government intentions to guarantee the maintenance and development of the Amazigh language and culture. This ideology will be brought to light by contrasting the constitutional rights that some Muslim and/or African countries grant to their citizens who speak different languages than the official one(s).