bluuebunny/crossref_metadata_2025_split huggingface dataset:
Portuguese validation of the Regret Intensity Scale (RIS-10) for measuring the intensity of regret associated with the provision of attention in health
Authors: Smiderle Fabiana Rosa Neves , Ramos-Silva Valmin , Castro Stela Maris de Jezus , Courvoisier Delphine Sophie , Mattiello Rita 
Published: November 2021

Objective. The aim of the study was to adapt and validate the Regret Intensity Scale-10 (RIS-10) for Brazilian health professionals.
Methods. The validation study took place in two phases, in which the first was the translation of the instruments and the second, the field validation using psychometric properties validity and reliability of the scale with 341 professionals (doctors, nurses and physiotherapists) linked to hospitals. Validity was assessed using content validities (six judges evaluation), criteria (correlation with the Life Satisfaction Scale - SWLS and Self-Reporting Questionnaire 20 -SRQ-20) and construct (exploratory analysis using the rotation method Promax, based on the slope graph and the Kaiser criterion and confirmatory using the structural equation model) after applying the questionnaire to professionals.Reliability was measured by Cronbach's α coefficient and retest test over a maximum period of 30 days. Reproducibility was calculated by intraclass correlation.
Results. A total of 341 professionals participated, with an average age of 38.6 ± 9.2 years. The content validity index (CVI) was 1.00, for all items of the scale in the proportion of agreement of the judges. Exploratory factor analysis showed a satisfactory correlation (Kaiser-Meyer-Olkin = 0.88), suggesting a two-factor model, which comprises the main components of the emotion of regret (Factor I – emoticons, Factor II - feelings), accounting for 64% of the total variation of the first factor. In the confirmation, the index standardized root mean squared residual = 0.063 was close to the acceptable and other values were below. The scale correlated positively with SRQ-20 (p < 0.001) and negatively with SLWS (p = 0.003). Reliability showed (Cronbach’s α = 0.863) and test–retest reliability showed lower values ​​than expected. The Bland-Altman graph showed a mean bias of -1.5 with lower and upper limits of 15.8 to 12.8 respectively.
Conclusion. The RIS-10 adapted for the population performed adequately in the psychometric properties evaluated for the assessment of the intensity of regret related to the provision of health care.
Nursing Professionals within the Intergenerational Context during the 20th and 21st Centuries: an Integrative Review
Authors: Rollan Oliveira Susana , Siles González José 
Published: November 2021

Objective. To describe the generational differences and similarities existing among nursing professionals of the 20th and 21st centuries and how these have influenced on the evolution of the profession.
Methods. Integrative review according to the methodology by Whittemore and Knafl. The key words used for the search were: nurses, intergenerational relations, Veterans, Baby Boom, X generation, and Millennials.
Results. The electronic search process yielded 10 documents (eight articles and two theses), all within the Anglo-Saxon environment (4 in Canada, 5 in the United States, and 1 in Australia). The documents recovered determined three principal themes: the intergenerational nursing workforce (n = 7), recruiting and retention within an intergenerational workforce (n = 2), and tutoring within an intergenerational nursing workforce (n = 1). The four generations of nursing professionals (X, Y, Baby Boomers, and Veterans) have different aptitudes, social and cultural setting, that coexist within the same work staff.
Conclusion. This study establishes the legitimacy of the intergenerational differences as an important variable of social categorization. The findings have the potential to improve generational comprehension and promote a more cohesive culture in clinical practice settings, besides conserving the legacy of the four generations of nursing professionals contributing to outline the identity of the nurses through the conservation of social, cultural, and professional experiences.
The comparison of total bile acid concentration and alcohol dehydrogenase activity as markers of intrahepatic cholestasis of pregnancy
Authors: Jelski Wojciech , Piechota Joanna , Orywal Karolina , Mroczko Barbara 
Published: November 2021

Introduction: Intrahepatic cholestasis of pregnancy (ICP) is the liver disorder in the second or early third trimester of pregnancy. It is characterized by pruritus with increased serum bile acids concentration and other liver function tests. ICP is connected with increased risk of fetal mortality, but is unfortunately detected quite late. Therefore, it is important to recognize the disease in its early stages. We aimed to investigate the serum alcohol dehydrogenase (ADH) activity and compare it with the concentration of total bile acid (TBA) in women with ICP.
Methods: Serum samples were taken for routine investigation from 80 pregnancies with ICP in the second or third trimester of pregnancy and from 80 healthy pregnant women in the same time of pregnancy. For measurement of class I activity we used the spectrofluorometric methods. The total ADH activitiy was measured by the photometric method.
Results: The analysis of results shows a statistically significant increase in the activity of ADH I and ADH total (about 60% and 41.3%, respectively). Activity of ADH I well correlated with aminotransferases (alanine ALT and aspartate AST) and total bile acids (TBA) concentration. The total ADH activity was also positively correlated with ALT, AST and total bile acids.
Conclusion: We can state that the activity of class I alcohol dehydrogenase isoenzyme in the sera of patients with ICP is increased and seems to be a good indicator of liver cell destruction during this disease and is comparable with the value of other markers.
Diagnostic criteria of lymphoproliferative diseases from the peripheral blood samples using a cell biochip
Authors: Fedyanina O. S. , Chuksina Yu. Yu. , Khmelevskaya A. N. , Khvastunova A. N. , Matveev Yu. N. , Kataeva E. V. , Filatov A. V. , Kuznetsova S. A. 
Published: November 2021

Background: At present, the diagnosis of lymphoproliferative disorders is based on the combination of blood or bone marrow smear morphology and immunophenotyping by flow cytometry. Immunophenotypic testing by flow cytometry technique is available only in big medical centers, which is not always convenient for a patient. Therefore, development of an available method for preliminary diagnosis of lymphoproliferative diseases not requiring special equipment seems relevant.Materials and methods: Peripheral blood mononuclear cells from 17 patients admitted to the hospital with suspicion of a lymphoproliferative disorder, and 17 healthy donors were studied on a cell biochip for determination of proportions of cells positive for various surface CD antigens. The diagnosis was verified by flow cytometry.Results: Compared to healthy controls and patients with T-cell lymphoproliferative disorders (TCLPD), the patients with B-cell lymphoproliferative disorders (BCLPD) had significantly lower proportion of CD7+ cells (medians, 7% and 73% respectively, p=2×10-6 for comparison with healthy controls; median 7% and 93% for comparison with TCLPD, p=0.032). In addition, the patients with BCLPD had higher proportion of peripheral СD19+ mononuclear cells, compared to that in the patients with TCLPD and healthy donors (medians 84% and 13% for comparison between BCLPD and healthy control, p=2×10-5; 84% and 3% for comparison of BCLPD and TCLPD, p=0.033). The patients with B-cell chronic lymphocytic leukemia had significantly higher CD5+ cells in the cell biochip compared to the patients with other BCLPD (medians 72% and 9%, p=0.024). The patients with TCLPD had significantly lower proportion of CD19+ cells than the healthy controls (medians, 3% and 13%, respectively, р=0.042).Conclusion: The study has demonstrated the potential to use the previously developed cell biochip for diagnosis of lymphoproliferative diseases. The biochip makes it possible to sort out white blood cells according to their surface differentiation antigen for their further morphological analysis. The cell biochip allows for the differential diagnosis between BCLPD and TCLPD and determination the lymphocyte clones based on the expression of immunoglobulin light chains.
THE IMPACT OF THE PRO AND CONS POLICIES IN JOKOWI ERA'S ON THE MACRO ECONOMY OF SOCIETY
Authors: Wardhana Akhmad Kusuma 
Published: November 2021

Introduction: Corona is a new variant of the virus that spreads very quickly. It is only by physical contact the virus capable on infecting human body as its host. Governments in various countries have implemented social restrictions or lockdowns to reduce the spread of the virus.Methods This study uses descriptive analysis method. The sample of this study is Jokowi's three policies on handling corona.Results: Not all of the policies contrary considered for the public are detrimental. The lack of a lockdown from the start was due to save foreign exchange from the tourism sector before the lockdown occurred.Conclusion and suggestion: The social restriction policy has not only resulted in positive way for the medical community, but also negative way with the decline of the national economy.
Effect of Kechuanting Acupoint Sticking Therapy On Asthma Control And Serum Metabolite Characteristics In Asthma Patients Treated With Long-Term Inhaled Corticosteroid-Formoterol
Authors: Zhao Shumei , Zhang Cong , Di Kuan , Gong Xiaoyan , Hu Jun , Li Hong , Ge Kaiwen , Zhang Puxi , Huang Qidong , Liu Lanying , Wang Hesheng , Shan Jinjun 
Published: November 2021

Abstract
Background: Despite the availability of inhaled corticosteroid-formoterol treatment, asthma in some patients is poorly controlled. Kechuanting acupoint sticking therapy may regulate immunological functions to improve asthma. In this study, we focused on the effect of Kechuanting acupoint sticking therapy on disease control and the characteristics of serum metabolites in asthma patients treated with long-term inhaled corticosteroid-formoterol. Methods: We enrolled healthy controls (n=30) and asthma patients treated with inhaled corticosteroid-formoterol for at least 6 months (n=30) and evaluated asthma control, lung function, and airway inflammation after treatment with Kechuanting acupoint sticking therapy (in asthma patients at baseline and week 6). Gas chromatography-mass spectrometry was used to analyze the serum samples of the two groups. Results: Asthma control test scores, forced expiratory volume in one second, and peak expiratory flow increased (P<0.01) at week 6 in the inhaled corticosteroid-formoterol+ Kechuanting acupoint sticking therapy group, while the level of fractional exhaled nitric oxide did not change significantly (P=0.359). Among the 46 significant metabolites in the asthma patients and healthy controls (at baseline), 12 were restored after 6 weeks of inhaled corticosteroid-formoterol+ Kechuanting acupoint sticking therapy treatment and 8 (e.g., glycine, sucrose, and glycerol) were correlated with the clinical characteristics. Conclusions: Kechuanting acupoint sticking therapy improved asthma control in patients treated with long-term inhaled corticosteroid-formoterol, and the serum metabolomic pathway analysis demonstrated the association of Kechuanting acupoint sticking therapy with carbohydrate, glycerolipid, and amino acid metabolism.Trial registration: https://www.chictr.org.cn, ChiCTR1800016644.
The effect of social Nervous (SaSo) exercise with insulin resistance (HOMA-IR) on gestational diabetes mellitus among Indonesian pregnant women: a quasi-experimental study
Authors: Afifah Effatul , Nurdiati Detty Siti , Hadi Hamam , Sofro Zainal Muttaqien , Sadewa Ahmad Hamim , Aji Arif Sabta 
Published: November 2021

Abstract
Background

Gestational diabetes mellitus (GDM) is a carbohydrate intolerance condition that is diagnosed for the first-time during pregnancy and is associated with various adverse pregnancy outcomes for both mother and child, such as increased rates of perinatal complications and long-term morbidity. Exercise is a strategy to reduce hyperglycemia experienced during gestational diabetes mellitus. One type of exercise that can be done is a social nervous exercise (SaSo). SaSo can stimulate the parasympathetic or myelinated vagus nerves and control blood glucose by stimulating autonomic nerves system so that nerve homeostasis and glucose homeostasis occur. This study aimed to determine the impact of a SaSo program consisting of warm-up, core (prayer movements) and cool-down exercises on glucose homeostasis (HOMA-IR) parameters in women with GDM.
Methods

The study used a quasi-experimental design. Thirty-seven women with GDM at 24-28 weeks gestation were divided into an experimental group (n=19) with a regularly supervised SaSo program (n=18). The control group received only standard antenatal care for GDM. The exercise program started from the time of diagnosis of diabetes to six weeks of intervention conducted twice per week with sessions lasting 40-45 minutes. Bivariate analysis was used to test the difference in means with pretest and posttest results.
Results

Majority of pregnant women were in the not at-risk age category for control and intervention groups (79% and 83%, respectively). The baseline data results for the experimental and control groups were homogeneous, with no difference in baseline variables (P>0.05). The social nervous exercise experimental group had lower mean difference (MD±SD) levels of insulin resistence in late pregnancy compared to the control group (-9.15±10.06 vs 3.42 ±14.84) (P=0.004).
Conclusions

A social nervous exercise program has a beneficial effect on insulin resistance (HOMA-IR) levels in late pregnancy. Further research needs to be done with larger studies to confirm the findings of this study.
Trial registration:

Ethical approval was obtained from the Medical and Health Research Ethics Committee of the Faculty of Medicine, Universitas Gadjah Mada Yogyakarta (KE/0978/08/2019).
The Delayed Decrease of Seismicity In The Eastern Margin of The Japan Sea Due To The Megathrust Event In 2011 Along The Japan Trench
Authors: Matsu'ura Ritsuko S. , Hashima Akinori , Ishibe Takeo 
Published: November 2021

Abstract
In the eastern margin of the Japan Sea, off the west coast of Tohoku district, the seismicity increased right after the M9 megathrust event off the east coast of the Tohoku district on March 11, 2011. Four months later, the seismicity decreased to the half level of that before the M9 event. Such quantitative study was done by the point-process model selection with AIC. The decrease lasted for eight years until an M6.7 event occurred within the area in 2019. When we compare the seismicity change between before and after the M9 event, with the post seismic change of the maximum shear stress obtained by the viscoelastic simulation for a thousand years after the M9 event, we can estimate a loading rate of the shear stress in the area before the M9 as 24 kPa/y. For the term after the M9 event, the rate is a half of it; 12 kPa/y. When we assume the whole dilatation change due to the M9 event had been canceled by the time of the M6.7, the increasing rate of the mean stress after the M9 event is 21 kPa/y at most. When we will be able to use JMA catalog for 2020 or later years, we can obtain the seismicity level after the M6.7 quantitatively, and we will be able to narrow down this estimation.
Anthropogenic droughts are expected to exacerbate water inequalities in postcolonial cities
Authors: Rusca Maria , Savelli Elisa , Baldassarre Giuliano Di , Biza Adriano , Messori Gabriele 
Published: November 2021

Abstract
There are growing concerns about the impacts of climate change on equitable urban development. As cities are becoming increasingly exposed to anthropogenic droughts, stakes are particularly high in contexts of severe vulnerability. Yet, the impacts of future urban droughts and the societal responses they will elicit remain poorly understood. Here we develop social-environmental scenarios of anthropogenic drought-related impacts in postcolonial cities, characterized by highly uneven development and differentiated levels of vulnerability. We show how unprecedented droughts are expected to polarize existing inequalities in water access and well-being across genders, race and socio-economic groups. Specifically, unprecedented droughts will likely exacerbate spatial inequalities, generate localized public health crises, and regress development progress in water access. These results suggest that effective climate policies must address water insecurity and other pre-existing inequalities, and develop equitable water conservation measures to ensure effective adaptation to future unprecedented extreme droughts.
Translational Development of A Tumor Junction Opening Technology
Authors: Kim Jiho , Li Chang , Wang Hongjie , Kaviraj Swarnendu , Singh Sanjay , Savergave Laxman , Raghuwanshi Arjun , Gil Sucheol , Germond Audrey , Baldessari Audrey , Chen Bingmae , Steve Roffler , Fender Pascal , Drescher Charles , Carter Darrick , Lieber André 
Published: November 2021

Abstract
Our goal is to overcome treatment resistance in ovarian cancer patients, which occurs in most cases after an initial positive response to chemotherapy. A central resistance mechanism is the maintenance of desmoglein-2 (DSG2)-positive tight junctions between malignant cells, which prevents drug penetration into the tumor. We generated JO4, a recombinant protein that binds to DSG2, resulting in the transient opening of junctions in epithelial tumors. Here, we present studies on the clinical translation of JO4 in combination with PEGylated liposomal doxorubicin/Doxil® for ovarian cancer therapy. A manufacturing process for cGMP-compliant production of JO4 was developed. GLP toxicology studies using material from this process in DSG2 transgenic mice and cynomolgus macaques showed no treatment-related toxicities after intravenous injection at doses reaching 24 mg/kg. Multiple cycles of intravenous JO4 plus Doxil® (4 cycles, 4 weeks apart, simulating the treatment regimen in the clinical trial) elicited antibodies against JO4 that increased with each cycle and were accompanied by elevation of pro-inflammatory cytokines IL6 and TNF. Pretreatment with steroids and cyclophosphamide reduced the anti-JO4 antibody response and blunted cytokine release. Our data indicate acceptable safety of our new treatment approach if immune reactions are monitored and counteracted with appropriate immune suppression.
Cu-Catalyzed, Mn-Mediated Propargylation and Allenylation of Aldehydes with Propargyl Bromides
Authors: Zhang Rongli , Xia Yanping , Yan Yuchen , Ouyang Lu 
Published: November 2021

Abstract
A simple, practical, and high chemo-selective method for the synthesis of propargyl alcohol and allenyl alcohols via Cu-catalyzed, Mn-mediated propargylation and allenylation of aldehydes with propargyl bromides has been established. When 3-bromo-1-propyne was conducted under the standard condition, the aldehydes were transformed to the corresponding propargylation products completely, while when 1-bromo-2-pentyne was used, allenic alcohol was the only product. Variety of homopropargyl alcohols and allenyl alcohols were obtained in high yields and the reaction is compatible with broad substrate scopes. In addition, the large-scale reaction could also be proceeded smoothly indicating the potential synthetic applications of this transformation.
Severe COVID-19 infection is associated with aberrant cytokine production by infected lung epithelial cells rather than by systemic immune dysfunction
Authors: Gajewski Thomas , Rouhani Sherin , Trujillo Jonathan , Pyzer Athalia , Yu Jovian , Fessler Jessica , Cabanov Alexandra , Higgs Emily , Cron Kyle , Zha Yuanyuan , Lu Yihao , Bloodworth Jeffrey , Abasiyanik Mustafa , Okrah Susan , Flood Blake , Hatogai Ken , Leung Michael , Pezeshk Apameh , Kozloff Lara , Reschke Robin , Strohbehn Garth , Chervin Carolina Soto , Kumar Madan , Schrantz Stephen , Madariaga Maria Lucia , Beavis Kathleen , Yeo Kiang-Teck , Sweis Randy , Segal Jeremy , Tay Savaş , Izumchenko Evgeny , Mueller Jeffrey , Chen Lin 
Published: November 2021

Abstract
The mechanisms explaining progression to severe COVID-19 remain poorly understood. It has been proposed that immune system dysregulation/over-stimulation may be implicated, but it is not clear how such processes would lead to respiratory failure. We performed comprehensive multiparameter immune monitoring in a tightly controlled cohort of 128 COVID-19 patients, and used the ratio of oxygen saturation to fraction of inspired oxygen (SpO2 / FiO2) as a physiologic measure of disease severity. Machine learning algorithms integrating 139 parameters identified IL-6 and CCL2 as two factors predictive of severe disease, consistent with the therapeutic benefit observed with anti-IL6-R antibody treatment. However, transcripts encoding these cytokines were not detected among circulating immune cells. Rather, in situ analysis of lung specimens using RNAscope and immunofluorescent staining revealed that elevated IL-6 and CCL2 were dominantly produced by infected lung type II pneumocytes. Severe disease was not associated with higher viral load, deficient antibody responses, or dysfunctional T cell responses. These results refine our understanding of severe COVID-19 pathophysiology, indicating that aberrant cytokine production by infected lung epithelial cells is a major driver of immunopathology. We propose that these factors cause local immune regulation towards the benefit of the virus.
Fungal Spoilage And Its Economic Impact On Maize (Zea Mays L.) And Wheat (Triticum aestivum L) In West Shoa, Ethiopia
Authors: Mohammed Kedir , Kumsa Fikadu 
Published: November 2021

Abstract
Food grains may be attacked by fungi in the field which can then develop rapidly during storage when conditions are suitable which result in losses in both quantity and quality in addition to decreasing nutritional value and mycotoxin production. Of the world’s grain harvest, lost during storage by microorganisms including insects, mites, and rodents is higher especially in developing countries. A study to assess fungal spoilage and contamination of two stored food grains of maize and wheat and its economic impact on the livelihood community were carried out in six localities, vis., Bako, Ejaji, Cheliya, Toke Kutaye, Ginde Beret and Holeta. A total of 120 samples (60maize and 60wheat) were collected using purposive and stratified random sampling. Isolation of fungi from collected food grains were done using dry inspection and incubation test (agar plate method) and identification was done based on cultural characteristics and microscopic features. Results of the current study indicated that the mean fungal contamination of the food grains had the highest levels of infection and contamination. Maize was infected by more than 11 different genera of 831 different fungi while the wheat seeds were also infected by 8 genera of 768 different molds. Across the study sites, Aspergillus, Penicillium, Fusarium and Alternaria were the most predominant fungal genera identified among the study sites. There was more mycotoxin producing fungal genera isolated from those samples of both maize and wheat with high level of contamination. Mycotoxin levels increased with storage time such that maize and wheat samples stored for more than six months may exceed the levels greater than the FDA/WHO regulatory limits. Hence, indicating that maize and wheat consumers in the study area are exposed to the danger of mycotoxin poisoning. Thus, there is the need for policy makers to establish and enforce food grain quality standards and regulations related to molds and mycotoxins across the country and specifically among study area to minimize health hazards related to consumption of contaminated foods.