bluuebunny/crossref_metadata_2025_split huggingface dataset:
From 30 million to zero malaria cases in China: lessons learned for China–Africa collaboration in malaria elimination
Authors: Chen Jun-Hu , Fen Jun , Zhou Xiao-Nong 
Published: April 2021

AbstractMalaria was once one of the most serious public health problems in China, with more than 30 million malaria cases annually before 1949. However, the disease burden has sharply declined and the epidemic areas has shrunken after the implementation of an integrated malaria control and elimination strategy, especially since 2000. Till now, China has successfully scaled up its efforts to become malaria-free and is currently being evaluated for malaria-free certification by the WHO. In the battle against malaria, China’s efforts have spanned generations, reducing from an incidence high of 122.9/10 000 (6.97 million cases) in 1954 to 0.06/10 000 (7855 cases) in 2010. In 2017, for the first time, China reached zero indigenous case of malaria, putting the country on track to record three consecutive years of zero transmission by 2020, accoding to the National Malaria Elimination Action Plan (2010–2020). China’s efforts to eliminate malaria is impressive, and the country is dedicated to sharing its lessons learned in malaria elimination—including, but not limited to, the application of novel genetics-based approaches—with other nations through new initiatives. China will promote international relationships and establish collaborative platforms on a wide range of topics in roughly 65 countries, including 20 African nations. China’s experience in applying innovative genetics-based approaches and tools to characterize malaria parasite populations, including surveillance of markers related to drug resistance, categorization of cases as indigenous or imported, and objective identification of the likely sources of infections to inform efforts towards malaria control and elimination in Africa could offer game-changing results when applied to settings with ongoing transmission.
Model-based reproduction and validation of the total spectra of a solar flare and their impact on the global environment at the X9.3 event of September 6, 2017
Authors: Watanabe Kyoko , Jin Hidekatsu , Nishimoto Shohei , Imada Shinsuke , Kawai Toshiki , Kawate Tomoko , Otsuka Yuichi , Shinbori Atsuki , Tsugawa Takuya , Nishioka Michi 
Published: April 2021

AbstractWe attempted to reproduce the total electron content (TEC) variation in the Earth's atmosphere from the temporal variation of the solar flare spectrum of the X9.3 flare on September 6, 2017. The flare spectrum from the Flare Irradiance Spectral Model (FISM), and the flare spectrum from the 1D hydrodynamic model, which considers the physics of plasma in the flare loop, are used in the GAIA model, which is a simulation model of the Earth's whole atmosphere and ionosphere, to calculate the TEC difference. We then compared these results with the observed TEC. When we used the FISM flare spectrum, the difference in TEC from the background was in a good agreement with the observation. However, when the flare spectrum of the 1D-hydrodynamic model was used, the result varied depending on the presence or absence of the background. This difference depending on the models is considered to represent which extreme ultraviolet (EUV) radiation is primarily responsible for increasing TEC. From the flare spectrum obtained from these models and the calculation result of TEC fluctuation using GAIA, it is considered that the enhancement in EUV emission by approximately 15–35 nm mainly contributes in increasing TEC rather than that of X-ray emission, which is thought to be mainly responsible for sudden ionospheric disturbance. In addition, from the altitude/wavelength distribution of the ionization rate of Earth's atmosphere by GAIA (Ground-to-topside Atmosphere and Ionosphere model for Aeronomy), it was found that EUV radiation of approximately 15–35 nm affects a wide altitude range of 120–300 km, and TEC enhancement is mainly caused by the ionization of nitrogen molecules.
Nonlinear wave growth theory of whistler-mode chorus and hiss emissions in the magnetosphere
Authors: Omura Yoshiharu 
Published: April 2021

AbstractNonlinear processes associated with the generation process of whistler-mode chorus emissions are summarized. The nonlinear dynamics of energetic electrons interacting with a coherent whistler-mode wave and the formation of electromagnetic electron holes or hills in the velocity phase space are described. The condition for resonant electrons to be free from the anomalous trapping at low pitch angles is obtained. In the presence of the inhomogeneity due to the frequency variation and the gradient of the magnetic field, the electron holes or hills result in resonant currents generating rising-tone emissions or falling-tone emissions, respectively. After formation of a coherent wave at a frequency of the maximum linear growth rate, triggering of the nonlinear wave growth takes place when the wave amplitude is above the threshold amplitude. The wave grows to a level close to the optimum wave amplitude as an absolute instability near the magnetic equator. The nonlinear growth rate at a position away from the equator is derived for a subtracted Maxwellian momentum distribution function with correction to the formulas in the past publications. The triggering process is repeated sequentially at progressively higher frequencies in the case of a rising-tone emission, generating subpackets forming a chorus element. With a higher plasma density as in the plasmasphere, the triggering of subpackets takes place concurrently over a wide range of frequency forming discrete hiss elements with varying frequencies. The mechanism of nonlinear wave damping due to quasi-parallel propagation from the equator is presented, which results in the formation of a gap at half the electron cyclotron frequency, separating a long rising-tone chorus emission into the upper-band and lower-band chorus emissions. The theoretical formulation of an oblique whistler mode wave and its interaction with energetic electrons at the n-th resonance is also presented along with derivation of the inhomogeneity factor.
Evaluation of the ‘Spaarne soft tissue procedure’ as a treatment for recurrent patellar dislocations: a four-in-one technique
Authors: Puijk Raymond , Rassir Rachid , Louwerens Jan K. G. , Sierevelt Inger N. , de Jong Tjitte , Nolte Peter A. 
Published: April 2021

Abstract
Purpose
The ‘Spaarne soft tissue procedure’, is a 4-in-1 soft tissue procedure that treats recurrent patellar dislocations in the young and active population. The procedure has not yet described elsewhere. The purpose of this study is to analyse the redislocation rate and to evaluate the postoperative knee function and patient satisfaction.

Methods
Twenty-seven patients (34 knees) underwent the four-in-one SST-procedure. The 4-step technique required a minor change in 2010, including the use of a smaller strip of the patellar tendon for transposition. After a median follow-up of 10.4 years, the redislocation rate was evaluated as the primary outcome measure. Secondary outcome measures were functional outcome (IKDC, Kujala, Lysholm and Tegner activity scale) and Numeric Rating Scales for satisfaction and pain.

Results
Redislocation occurred in 8 cases (23.5%) and subluxation occurred in 13 cases (38.2%) post-surgery. A significant higher number of redislocations and subluxations were seen before 2010 (p = 0.04, p = 0.03). The median postoperative IKDC, Lysholm and Kujala scores for the total group were 54, 76 and 81 respectively. Pre- and postoperative Tegner activity scale were both level 3. Median NRS scores during rest, walking and sports were 1, 3 and 5 respectively. Satisfaction with the procedure was reported as ‘excellent’ or ‘good’ by 79% of the patients.

Conclusion
Despite the high overall redislocation rate and increased pain scores, the SST-procedure shows to be a safe procedure in patients with recurrent patellar dislocations based on the cases after 2010. Mid- and long-term results show moderate to good functional outcomes and satisfaction.

Level of evidence
Therapeutic retrospective cohort study, LEVEL III
The value of bone marrow, liver, and spleen imaging in diagnosis, prognostication, and follow-up monitoring of myeloproliferative neoplasms: a systematic review
Authors: Slot Stefanie , van de Donk Niels W. C. J. , Otten René H. J. , Boden Bouke J. H. , Zijlstra Josée , Raijmakers Pieter G. H. M. , Zweegman Sonja 
Published: April 2021

AbstractBackgroundDiagnostic and treatment response criteria for the JAK2/CALR/MPL mutation-related myeloproliferative neoplasms (MPNs) are largely based on bone marrow (BM) biopsy results. However, these biopsies have several limitations, such as the risk of sampling error. Also, the prognostic impact of BM abnormalities is largely unclear. Although not currently used in clinical practice, imaging techniques might offer additional information. In this review, we investigated the value of BM, liver, and spleen imaging for diagnosis, prognostication, and response monitoring of the JAK2/CALR/MPL mutation-related MPNs (i.e. essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF)).MethodsA systematic literature search was performed via PubMed, Embase and the Cochrane Library up to 2020 March 26th. Of 5505 identified records, 55 publications met the eligibility criteria (i.e. containing original data on the imaging appearance of BM, spleen, or liver in adult ET, PV, or MF patients, published in a peer-reviewed journal, written in English).ResultsMany explorative studies described imaging features, sometimes with comparisons to clinical characteristics. Studies reporting measures of diagnostic accuracy included 1) splenic transient elastography to predict BM fibrosis grade in MF, 2) dynamic contrast-enhanced MRI to discern MF patients from ET patients and healthy controls, and 3) 18-fluorodeoxyglucose PET to detect residual disease after stem cell transplantation in MF. The diagnostic accuracies of radiography and99mTc-colloid scintigraphy were derived from several other articles. Except for the study on 18-fluorodeoxyglucose PET, we established substantial concerns regarding risk of bias and applicability across these studies, using the QUADAS-2 tool. Three publications described a correlation between imaging results and prognosis, of which one quantified the effect.ConclusionsBased on current data, MRI (T1-weighted/STIR, Dixon) seems especially promising for the evaluation of BM fat content - and indirectly cellularity/fibrosis - in MF, and possibly for estimating BM cellularity in ET/PV. 18-fluorodeoxyglucose and 18-fluorothymidine PET/CT might be useful for evaluating BM fibrosis, with good reported accuracy of the former for the diagnosis of residual disease. Further research on these and other techniques is warranted to determine their exact value. Future researchers should improve methodology and focus on evaluation of diagnostic accuracy and prognostic implications of results.
The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts
Authors: Chen Haitian , Zhang Shaofeng , Wu Yanxin , Li Zhuyu , Wang Dongyu , Cai Shiqin , Wang Zilian 
Published: April 2021

Abstract
Background
Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM).

Methods
High-throughput sequencing was used to collect the plasma circRNAs expression profiles of GDM patients. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to measure the expressions of circ_0008285 and circ_0001173 in the plasma specimens. The Pearson’s correlation test was employed to assess the correlation between 2 circRNAs expression and the clinicopathologic data. Two circRNAs expression was verified in high glucose (HG)-induced HTR-8/SVneo cells. MTS, transwell assay was used to evaluate the effects of circ_0008285 expression on HG-induced HTR-8/SVneo cells. The network of circ_0008285 was constructed using cytocape.

Results
In GDM patients, the expression of circ_0008285 was significantly upregulated, while that of circ_0001173 was decreased. Circ_0008285 was significantly correlated with the total cholesterol and LDL-C levels. Circ_0001173 was significantly correlated with glycated hemoglobin. HG promoted the proliferation, invasion, and migration in HTR-8/SVneo cells, while the knockdown of circ_0008285 exerted reverse effects. In addition, network construction exhibited that circ_0008285 had 45 miRNA binding sites, which correlated with 444 mRNA.

Conclusions
circ_0008285 plays an important role and provides a clue for the usage of therapeutic targets in the development of GDM.
Emergent salvage surgery for massive hemoptysis after proton beam therapy for lung cancer: a case report
Authors: Hino Haruaki , Nakahama Kahori , Ogata Makoto , Kibata Kayoko , Miyasaka Chika , Utsumi Takahiro , Maru Natsumi , Matsui Hiroshi , Taniguchi Yohei , Saito Tomohito , Tsuta Koji , Murakawa Tomohiro 
Published: April 2021

Abstract
Background
Salvage surgery is an effective therapeutic option for patients experiencing relapses after chemoradiotherapy for advanced-stage lung cancer or after high-dose radiotherapy for early-stage lung cancer. We report a case involving an emergent salvage surgery for a patient with massive hemoptysis who developed lung cancer recurrence after undergoing proton beam therapy 7 years prior to presentation.

Case presentation
A 70-year-old male patient was emergently admitted due to massive hemoptysis. He had undergone proton beam therapy for a stage I adenocarcinoma of the left upper lobe 7 years ago, and was receiving chemotherapy for local recurrence. We performed an emergent salvage pulmonary resection to achieve hemostasis. During the operation, we confirmed the presence of a left broncho-pulmonary arterial fistula, which was considered as the origin of the massive hemoptysis. We repaired the fistula between the pulmonary artery and left upper bronchus without incident; an orifice of the fistula at the left pulmonary artery was sutured using a non-absorbable monofilament, and the central portion of the orifice of the fistula at the left upper bronchus was closed with a mechanical stapling device. The postoperative diagnosis was of an adenocarcinoma—ypT3(pm1) N0M1a (dissemination)-IVA, ef1b. The patient has survived for over a year with the cancer in almost complete remission following the administration of an epidermal growth factor receptor tyrosine kinase inhibitor.

Conclusions
Emergent salvage surgery demands high skill levels with optimal timing and correct patient selection. Our case suggested that the procedure played an important role in controlling serious bleeding and/or infectious conditions. Consequently, he could receive chemotherapy again and survive for over a year.
Raman spectroscopic detection of interleukin-10 and angiotensin converting enzyme
Authors: Zhang Shuo , van der Mee Frederieke A. M. , Erckens Roel J. , Webers Carroll A. B. , Berendschot Tos T. J. M. 
Published: April 2021

AbstractIn this report we present a confocal Raman system to identify the unique spectral features of two proteins, Interleukin-10 and Angiotensin Converting Enzyme. Characteristic Raman spectra were successfully acquired and identified for the first time to our knowledge, showing the potential of Raman spectroscopy as a non-invasive investigation tool for biomedical applications.
Antimicrobial activity of bacterial endophytes from Chirata (Swertia chirata Wall.) and Datura (Datura stramonium L.)
Authors: Devi Rimashree , Nath Tankeswar , Boruah Rashmi Rekha , Darphang Bishya , Nath Pranab Kumar , Das Priyanka , Sarmah Bidyut Kumar 
Published: April 2021

Abstract
Background
Exploration of biocides in microbial system becomes increasingly interesting. Among the different microbial systems, the study of endophytes becomes an important field of research because of their agricultural as well as pharmaceutical importance. Bacterial endophytes from two medicinal plants from North Easter states of India had been studied for their potential antibacterial and antifungal properties.

Results
Bacterial endophytes from two medicinal plant species abundantly available in North Eastern states of India, Chirata (Swertia chirata) and Datura (Datura stramonium), had been isolated and studied for their anti-bacterial and anti-fungal activities. Six bacterial endophytes were isolated from Chirata and 5 from Datura. All these bacterial isolates were initially isolated by observing their colony morphology, and then 9 morphologically distinct bacterial isolates were identified at molecular level by their 16s rRNA sequencing. Among the identified isolates, 5 were found to be belonged to genus Staphylococcus, 2 Bacillus, and one each belonged to Rhodococcus and Cupriavidus. Antibacterial study was carried out against 2 plant pathogenic bacteria, viz., Xanthomonas oryzae and Ralstonia solanacearum. Antifungal study was carried out against 2 plant pathogenic fungi, viz., Fusarium oxysporum and F. solani. Out of 6 bacterial isolates from Chirata, one showed antibacterial as well as antifungal properties, and another one showed antifungal properties only. Likewise, out of 5 bacterial isolates from Datura, one found to have both antibacterial and antifungal properties, and another one has only antifungal properties.

Conclusion
Few bacterial endophytes isolated from S. chirata and D. stramonium L., abundantly available in North Eastern part of India, had potential antibacterial as well as antifungal properties. This could be considered as the baseline information on potential antibacterial and antifungal agents from bacterial endophytes. Further investigations are required to assess their efficacy against several other bacterial and fungal diseases of economic importance.
Applicability of PD-L1 tests to tailor triple-negative breast cancer treatment in Brazil
Authors: Leite Kátia Ramos Moreira , Barrios Carlos Henrique , Buzaid Antônio Carlos , Gagliato Débora , Gobbi Helenice , Soares Fernando 
Published: April 2021

Abstract
Background
Triple-negative breast cancer (TNBC) is a heterogeneous disease that represents 10–20% of breast cancer cases. The prognosis for advanced TNBC is usually poor, with a median overall survival of approximately 18 months or less.

Main text
New targeted therapies such as anti-PD-L1 agents are emerging as an option to treat advanced TNBC. A panel of 6 national experts with an active interest in breast cancer convened online. Panel members had either clinical or pathology experience in breast cancer. The experts pre-defined critical questions in the management of PD-L1 in TNBC, and a literature review was performed for selected topics before the online meeting.

Conclusion
The experts led active discussions involving a multidisciplinary team comprising pathologists and clinical oncologists. The meeting served to discuss the most relevant issues. A total of 10 critical questions for PD-L1+ TNBC were debated and are presented in this review. This article discusses the current landscape for PD-L1 tests in TNBC in Brazil.
Impact of COVID-19 pandemic and related isolation measures on violence against children in Egypt
Authors: AboKresha Seham Ahmed , Abdelkreem Elsayed , Ali Rasha Abd Elhameed 
Published: April 2021

Abstract
Background
Coronavirus disease 2019 (COVID-19) and related isolation measures have substantial adverse economic, social, and psychological consequences and expose children to increased risk of violence. The present study aimed to investigate the impact of the COVID-19 pandemic on violence against children in Egypt.

Methods
An online survey, in Arabic, was disseminated during the period from 9 to 13 April 2020, to parents of children who were up to 18 years old residing in Egypt, selected using a snowball sampling technique, during the period from 25 March to 8 April during the implementation of the nationwide compulsory isolation measures against COVID-19 (25 March to 8 April 2020). The survey covered three areas: socio-demographic data, psychological impact measured using the Impact of Event Scale-Revised (IES-R), and violence against children during the past 2 weeks measured using a modified parent-report of a child abuse screening tool (ICAST-P) developed by the International Society for the Prevention of Child Abuse and Neglect.

Results
Out of 1118 completed survey responses, 90.5% of children were subjected to violent discipline, 88.7% experienced psychological aggression, and 43.2% encountered severe physical punishment. Approximately 60% of respondents reported a moderate-to-severe psychological impact (IES-R scores ≥ 33), which was associated with a higher rate of violent discipline (OR: 9.3; 95% CI: 5.37–16.027; p < 0.001).

Conclusions
This is the first study in Egypt to provide evidence on the association of COVID-19 pandemic, its psychological impact, and increased rates of violence against children. Effective multilevel strategies are urgently required to protect children from violence and its catastrophic consequences during the continually evolving COVID-19 pandemic.
An Oral Myofunctional Exercise Prescription For Obstructive Sleep Apnea
Authors: Sechser Nasya R. , Overhue Hadlie L. , Van Guilder Gary P. 
Published: April 2021

Apply It!
After having read this article, the health and fitness professional will be able to
▪ Describe the signs/symptoms, risk factors, and causes of obstructive sleep apnea
▪ Identify the anatomical location and functions of the primary oropharyngeal skeletal muscles
▪ Instruct how to perform oropharyngeal exercises to a client/patient
▪ Integrate evidence-based oropharyngeal exercise training into a physical activity plan for persons suffering from obstructive sleep apnea
The diagnostic value of intravoxel incoherent motion imaging in differentiating high-grade from low-grade gliomas: a systematic review and meta-analysis
Authors: Luo Hechuan , He Ling , Cheng Weiqin , Gao Sijie 
Published: April 2021

Objective:
This meta-analysis was carried out for assessing the accuracy of intravoxel incoherent motion (IVIM) parameters true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) in differentiating low-grade gliomas (LGGs) from high-grade gliomas (HGGs).

Methods:
Literatures concerning IVIM in the grading of brain gliomas published prior to October 20, 2020, searched in the Embase, PubMed, and Cochrane library. Use the quality assessment of diagnostic accuracy studies 2 (QUADAS 2) to evaluate the quality of studies. We estimated the pooled sensitivity, specificity, and the area under the summary ROC (SROC) curve to identification the accuracy of IVIM parameters D, D*, and f evaluation in grading gliomas.

Results:
Totally, 6 articles including 252 brain gliomas conform to the inclusion criteria. The pooled sensitivity of parameters D, D*, and f derived from IVIM were 0.85 (95%Cl, 0.76–0.91), 0.78 (95%Cl, 0.71–0.85), and 0.89 (95%Cl, 0.76–0.96), respectively. The pooled specificity were 0.78 (95%Cl, 0.60–0.90), 0.68 (95%Cl, 0.56–0.79), and 0.88 (95%Cl, 0.76–0.94), respectively. Meanwhile, the AUC of SROC curve were 0.89 (95%Cl, 0.86–0.92) , 0.81 (95%Cl, 0.77–0.84), and 0.94 (95%Cl, 0.92–0.96), respectively.

Conclusion:
This meta-analysis suggested that IVIM parameters D, D*, and f have moderate or high diagnosis value accuracy in differentiating HGGs from LGGs, and the parameter f has greater sensitivity and specificity. Standardized methodology is warranted to guide the use of this method for clinical decision-making. However, more clinical studies are needed to prove our view.

Advances in knowledge:
IVIM parameter f showed greater sensitivity and specificity, as well as excellent performance than parameter D* and D.