bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Visual Behavior to Signage Design: A Wayfinding Experiment with Eye-Tracking in Satellite Terminal of PVG Airport
Authors: Sun Chengyu , Li Shuyang , Lin Yinshan , Hu Weilin 
Published: September 2021

AbstractPassengers principally rely on signage to making wayfinding decisions in transportation buildings. Most existing research focuses on the analysis of the wayfinding trajectory, but there is less attention on the process of how passengers make the wayfinding decision. So, it is hard to accurately locate the causes of the wrong wayfinding decision. Taking the Satellite Terminal of Shanghai Pudong International Airport (PVG Airport) as an example, we adopted the eye-tracking technology and recorded the eye-tracking data of passengers observing the signage and making wayfinding decisions. Then, we compared and analyzed the data, presenting it by data visualization. This study found the causes of passengers making wrong wayfinding decisions and the visual behavior of wayfinding: the reconfirmation behavior, the priority of attention, and the clockwise observation. Finally, corresponding suggestions for signage design optimization are put forward regarding some wayfinding decision points. As a result, the optimized signage system in the satellite terminal is welcomed by the passengers two months later according to monthly questionnaires.
A Framework for Cypher-Physical Human-robot Collaborative Immersive MR Interaction – Beaux Arts Ball 4.0
Authors: Na Risu , Dai Haocheng 
Published: September 2021

AbstractIn this paper, we presented a human-robot collaborative mixed reality application – Beaux Arts Ball 4.0, in which a real-time interactive hybrid and physical architectural environment were designed and experienced through the tools and techniques of mixed reality, cypher-physical, teleoperation, telepresence, and automation. The application engaged the user and observer in a continuous loop of architectural transformation during the experience, where every type of sensory was blurred between physical and digital perception.
Towards Self-shaping Metamaterial Shells:
Authors: Özdemir E. , Kiesewetter L. , Antorveza K. , Cheng T. , Leder S. , Wood D. , Menges A. 
Published: September 2021

AbstractDouble curvature enables elegant and material-efficient shell structures, but their construction typically relies on heavy machining, manual labor, and the additional use of material wasted as one-off formwork. Using a material’s intrinsic properties for self-shaping is an energy and resource-efficient solution to this problem. This research presents a fabrication approach for self-shaping double-curved shell structures combining the hygroscopic shape-changing and scalability of wood actuators with the tunability of 3D-printed metamaterial patterning. Using hybrid robotic fabrication, components are additively manufactured flat and self-shape to a pre-programmed configuration through drying. A computational design workflow including a lattice and shell-based finite element model was developed for the design of the metamaterial pattern, actuator layout, and shape prediction. The workflow was tested through physical prototypes at centimeter and meter scales. The results show an architectural scale proof of concept for self-shaping double-curved shell structures as a resource-efficient physical form generation method.
Di-terial – Matching Digital Fabrication and Natural Grown Resources for the Development of Resource Efficient Structures
Authors: Amtsberg Felix , Mueller Caitlin , Raspall Felix 
Published: September 2021

AbstractThe research presented in this paper focusses on the concept of “Di-terial” which aims to merge digital design and fabrication technology with natural materials such as bamboo poles and raw timber. It proposes a digital workflow that uses sensing techniques to gain individual material information of natural, unprocessed construction resources and identify their individual strengths and characteristics and therefore its potential in load-carrying structures. This information is then used to develop bespoke designs and fabrication concepts, bridging the gap between unprocessed material and automated fabrication setups. Two case studies, developed to prove this concept, are described and compared. Both cases focused on the development of spatial structures using node-bar combinations of local resources.
Bio-Tile: An Intelligent Hybrid-Infrastructure
Authors: Pezeshk Sara 
Published: September 2021

AbstractBio-tile is a multipurpose artifact designed for protecting the coastline from erosion while creating a landscape element and an architectural experience for visitors. Bio-tile performs as a mitigation strategy to slow down erosion while promoting biodiversity. This paper describes the methodology used to develop the bio-tile as the nexus between digital and environmental for resolving coastline challenges through material tectonics. A non-linear algorithm and nature’s inherent code are used to develop the Bio-tile, a nature-based hybrid infrastructure. This approach aims to generate a performance-oriented design by using emergence theory to construct shoreline elements adaptive to climatic conditions.
Two-loop radiative seesaw, muon g − 2, and τ-lepton-flavor violation with DM constraints
Authors: Chen Chuan-Hung , Nomura Takaaki 
Published: September 2021

Abstract
The quartic scalar coupling λ5 term, which violates the lepton-number by two units in the Ma-model, is phenomenologically small when the model is applied to the lepton-flavor violation (LFV) processes. In order to dynamically generate the λ5 parameter through quantum loop effects and retain the dark matter (DM) candidate, we extend the Ma-model by adding a Z2-odd vector-like lepton doublet and a Z2-even Majorana singlet. With the new couplings to the Higgs and gauge bosons, the observed DM relic density can be explained when the upper limits from the DM-nucleon scattering cross sections are satisfied. In addition to the neutrino data and LFV constraints, it is found that the DM relic density can significantly exclude the free parameter space. Nevertheless, the resulting muon g − 2 mediated by the inert charged-Higgs can fit the 4.2σ deviation between the experimental measurement and the SM result, and the branching ratio for τ → μγ can be as large as the current upper limit when the rare μ → (eγ, 3e) decays are suppressed. In addition, it is found that the resulting BR(τ → μρ) can reach the sensitivity of Belle II with an integrated luminosity of 50 ab−1.
Efficient numerical integration of thermal interaction rates
Authors: Jackson G. , Laine M. 
Published: September 2021

Abstract
In many problems in particle cosmology, interaction rates are dominated by 2 ↔ 2 scatterings, or get a substantial contribution from them, given that 1 ↔ 2 and 1 ↔ 3 reactions are phase-space suppressed. We describe an algorithm to represent, regularize, and evaluate a class of thermal 2 ↔ 2 and 1 ↔ 3 interaction rates for general momenta, masses, chemical potentials, and helicity projections. A key ingredient is an automated inclusion of virtual corrections to 1 ↔ 2 scatterings, which eliminate logarithmic and double-logarithmic IR divergences from the real 2 ↔ 2 and 1 ↔ 3 processes. We also review thermal and chemical potential induced contributions that require resummation if plasma particles are ultrarelativistic.
Casein Kinase-1-Alpha Inhibitor (D4476) Sensitizes Microsatellite Instable Colorectal Cancer Cells to 5-Fluorouracil via Authophagy Flux Inhibition
Authors: Siri Morvarid , Behrouj Hamid , Dastghaib Sanaz , Zamani Mozhdeh , Likus Wirginia , Rezaie Sedigheh , Hudecki Jacek , Khazayel Saeed , Łos Marek J. , Mokarram Pooneh , Ghavami Saeid 
Published: September 2021

AbstractAdjuvant chemotherapy with 5-fluorouracil (5-FU) does not improve survival of patients suffering from a form of colorectal cancer (CRC) characterized by high level of microsatellite instability (MSI-H). Given the importance of autophagy and multi-drug-resistant (MDR) proteins in chemotherapy resistance, as well as the role of casein kinase 1-alpha (CK1α) in the regulation of autophagy, we tested the combined effect of 5-FU and CK1α inhibitor (D4476) on HCT116 cells as a model of MSI-H colorectal cancer. To achieve this goal, the gene expression of Beclin1 and MDR genes, ABCG2 and ABCC3 were analyzed using quantitative real-time polymerase chain reaction. We used immunoblotting to measure autophagy flux (LC3, p62) and flow cytometry to detect apoptosis. Our findings showed that combination treatment with 5-FU and D4476 inhibited autophagy flux. Moreover, 5-FU and D4476 combination therapy induced G2, S and G1 phase arrests and it depleted mRNA of both cell proliferation-related genes and MDR-related genes (ABCG2, cyclin D1 and c-myc). Hence, our data indicates that targeting of CK1α may increase the sensitivity of HCT116 cells to 5-FU. To our knowledge, this is the first description of sensitization of CRC cells to 5-FU chemotherapy by CK1α inhibitor.
Graphic abstract
The impact of CD4+CD28null T lymphocytes on atrial fibrillation: a potential pathophysiological pathway
Authors: Hammer Andreas , Niessner Alexander , Sulzgruber Patrick 
Published: September 2021

AbstractIntroductionAtrial fibrillation (AF) represents the most common cardiac arrhythmia in daily clinical practice and substantially impacts affected patients by elevation of both morbidity and mortality. Previous investigations proved that inflammatory processes are closely linked to this multifactorial pathogenesis—especially autoreactive CD4+CD28nullT cells received in-depth attention.PurposeConsequently, a potential pathophysiological pathway of the impact of CD4+CD28null T lymphocytes on the development and progression AF can be outlined.ConclusionConsidering the available data in the literature, it needs to be assumed that CD4+CD28nullT lymphocytes are mainly involved in the development of AF and disease progression. Of utmost importance, it can be considered as the result of a T-cell-mediated auto-immune reaction among myocardial tissue. However, mechanisms which recruit CD4+CD28nullcells in cardiac tissue remain unclear and need further investigation.
Asymptotic Properties of Solutions to the Cauchy Problem for Degenerate Parabolic Equations with Inhomogeneous Density on Manifolds
Authors: Andreucci Daniele , Tedeev Anatoli F. 
Published: September 2021

AbstractWe consider the Cauchy problem for doubly nonlinear degenerate parabolic equations with inhomogeneous density on noncompact Riemannian manifolds. We give a qualitative classification of the behavior of the solutions of the problem depending on the behavior of the density function at infinity and the geometry of the manifold, which is described in terms of its isoperimetric function. We establish for the solutions properties as: stabilization of the solution to zero for large times, finite speed of propagation, universal bounds of the solution, blow up of the interface. Each one of these behaviors of course takes place in a suitable range of parameters, whose definition involves a universal geometrical characteristic function, depending both on the geometry of the manifold and on the asymptotics of the density at infinity.
Temporal patterns in offshore bird abundance during the breeding season at the Dutch North Sea coast
Authors: van Erp Jens A. , van Loon E. Emiel , Camphuysen Kees J. , Shamoun-Baranes Judy 
Published: September 2021

AbstractThe expanding development of offshore wind farms brings a growing concern about the human impact on seabirds. To assess this impact a better understanding of offshore bird abundance is needed. The aim of this study was to investigate offshore bird abundance in the breeding season and model the effect of temporally predictable environmental variables. We used a bird radar, situated at the edge of a wind farm (52.427827° N, 4.185345° E), to record hourly aerial bird abundance at the North Sea near the Dutch coast between May 1st and July 15th in 2019 and 2020, of which 1879 h (51.5%) were analysed. The effect of sun azimuth, week in the breeding season, and astronomic tide was evaluated using generalized additive modelling. Sun azimuth and week in the breeding season had a modest and statistically significant (p < 0.001) effect on bird abundance, while astronomic tide did not. Hourly predicted abundance peaked after sunrise and before sunset, and abundance increased throughout the breeding season until the end of June, after which it decreased slightly. Though these effects were significant, a large portion of variance in hourly abundance remained unexplained. The high variability in bird abundance at scales ranging from hours up to weeks emphasizes the need for long-term and continuous data which radar technology can provide.
Two adjacent C-terminal mutations enable expression of aryl-alcohol oxidase from Pleurotus eryngii in Pichia pastoris
Authors: Jankowski Nina , Urlacher Vlada B. , Koschorreck Katja 
Published: September 2021

AbstractFungal aryl-alcohol oxidases (AAOs) are attractive biocatalysts because they selectively oxidize a broad range of aromatic and aliphatic allylic primary alcohols while yielding hydrogen peroxide as the only by-product. However, their use is hampered by challenging and often unsuccessful heterologous expression. Production of PeAAO1 from Pleurotus eryngii ATCC 90787 in Pichia pastoris failed, while PeAAO2 from P. eryngii P34 with an amino acid identity of 99% was expressed at high yields. By successively introducing mutations in PeAAO1 to mimic the sequence of PeAAO2, the double mutant PeAAO1 ER with mutations K583E and Q584R was constructed, that was successfully expressed in P. pastoris. Functional expression was enhanced up to 155 U/l via further replacements D361N (variant NER) or V367A (variant AER). Fed-batch cultivation of recombinant P. pastoris yielded up to 116 mg/l of active variants. Glycosylated PeAAO1 variants demonstrated high stability and catalytic efficiencies similar to PeAAO2. Interestingly, P. pastoris expressing PeAAO1 variant ER contained roughly 13 gene copies but showed similar volumetric activity as NER and AER with one to two gene copies and four times lower mRNA levels. Additional H-bonds and salt bridges introduced by mutations K583E and Q584R might facilitate heterologous expression by enhanced protein folding.Key points• PeAAO1 not expressed in P. pastoris and PeAAO2 well-expressed in Pichia differ at 7 positions.• Expression of PeAAO1 in P. pastoris achieved through mutagenesis based on PeAAO2 sequence.• Combination of K583E and Q584R is essential for expression of PeAAO1 in P. pastoris.
Polyhydroxyalkanoates, bacterially synthesized polymers, as a source of chemical compounds for the synthesis of advanced materials and bioactive molecules
Authors: Guzik Maciej W. 
Published: September 2021

AbstractResearch into polyhydroxyalkanoates (PHAs) is growing exponentially. These bacterially derived polyesters offer a spectrum of possible applications, such as in manufacturing of daily-use objects, production of medical devices and implantable objects, or as synthons in chemical and pharmaceutical industries. Thanks to their broad physicochemical features, PHAs can be seen as polymers of the future, which can replace traditional petrochemical equivalents. As they are synthesized by bacteria through fermentation processes, these polyesters can be obtained from virtually any carbon source in a sustainable manner. Characterized by biodegradability and biocompatibility, they are used in many industries, ranging from production of everyday objects to medical applications. Furthermore, as they are built from bioactive monomers, namely (R)-3-hydroxyacids, they provide a platform for the synthesis of advanced chemical compounds. In this mini review, the reader will be acquainted with recent studies conducted at the Jerzy Haber Institute of Catalysis and Surface Chemistry of the Polish Academy of Sciences in collaboration with other groups that have contributed to the development of PHA-based medical materials, bioactive molecules and novel green solvents derived from PHA monomers.Key points• Polyhydroxyalkanoates are emerging polymers for biomedical applications• Polyhydroxyalkanoates can be modified easily to provide novel materials• (R)-3-Hydroxyacids are good synthons for bioactive substances and green solvents
How can fertility counseling be implemented for every newly diagnosed pediatric patient facing gonadotoxic treatment?-A single-center experience
Authors: Barnbrock Anke , Salzmann-Manrique Emilia , Sänger Nicole , Fiegel Henning , Ochsendorf Falk , Klingebiel Thomas , Bader Peter , Jarisch Andrea 
Published: September 2021

AbstractSince the survival rates of pediatric patients undergoing cancer treatment or hematopoietic stem cell transplantation (HSCT) have increased rapidly in recent decades, the late effects of treatment are now an important focus of patient care. Access to fertility preservation (FP) procedures as well as their financing differs considerably across Europe. However, some countries in Europe have recently changed the legal basis for financing FP procedures; therefore, the implementation of structures is mandatory to give patients access to FP. In this prospective cohort study, we characterized the process for establishing pediatric fertility counseling, including the development of an in-house standard procedure for recommendations regarding FP with potentially gonadotoxic treatment and valuating data from all FP counseling sessions. All data concerning patient characteristics (pubertal status, disease group) and recommendation of FP measures were prospectively collected and adoption of FP measures analyzed. Prior to the establishment of a structured process for FP in our pediatric oncology and stem cell transplantation center, there was no standardized FP counseling. We demonstrate that with the establishment of an inhouse standard procedure, it is possible to give consistent yet individualized FP counseling to approximately 90% of our patients facing gonadotoxic treatment, counseling over 200 patients between 2017 and 2019. This pilot study could potentially be adapted in other pediatric hematology, oncology, and stem cell transplantation centers to allow a more standardized handling of FP counseling for all patients facing gonadotoxic treatment.
Robotic versus transanal total mesorectal excision in sexual, anorectal, and urinary function: a multicenter, prospective, observational study
Authors: Grass Julia-Kristin , Persiani Roberto , Tirelli Flavio , Chen Chien-Chih , Caricato Marco , Pecorino Alice , Lang Isabelle J. , Kemper Marius , Izbicki Jakob R. , Melling Nathaniel , Perez Daniel 
Published: September 2021

Abstract
Purpose
Improved long-term survival after low anterior resection (LAR) for rectal cancer highlights the importance of functional outcome. Urogenital and anorectal dysfunction is frequently reported after conventional LAR. Advanced minimally invasive techniques such as robotic (RoTME) and transanal total mesorectal excision (TaTME) might improve functional results by precisely dissecting and preserving autonomic nerves. We compared functional outcomes after RoTME or TaTME in a multicenter study.

Methods
One hundred twenty patients (55 RoTME/65 TaTME) were prospectively included in four participating centers. Anorectal (Wexner and low anterior resection syndrome (LARS) Score), urinary (International Consultation on Incontinence—Male/Female Lower Urinary Tract Symptoms Score (ICIQ-MLUTS/ICIQ-FLUTS) and International Prostate Symptom Scale (IPSS)), and sexual (International Index of Erectile Function (IIEF), Female Sexual Function Index (FSFI)) outcomes at 12 months after surgery were compared to preoperative scores. The response rate to the 1-year postoperative functional assessment by questionnaire was 79.5%.

Results
RoTME enabled better anorectal function compared to TaTME (LARS score 4.3 ± 2.2 vs. 9.8 ± 1.5, p = 0.038, respectively). TaTME proved superior at preserving male urinary function, while female urinary function was comparable in both groups, with only mild postoperative impairment (RoTME vs. TaTME, respectively: ICIQ-MLUTS 13.8 ± 4.9 vs. 1.8 ± 5.8, p = 0.038; ICIQ-FLUTS Incontinence Score − 0.3 ± 1.0 vs. − 0.2 ± 0.9, p = 0.844). Both techniques demonstrated comparable male (RoTME − 13.4 ± 2.7 vs. TaTME − 11.7 ± 3.4, p = 0.615) and female (RoTME 5.2 ± 4.6 vs. TaTME 10.5 ± 6.4, p = 0.254) sexual function.

Conclusion
After adjustment for risk factors, RoTME provided better anorectal functional results, whereas TaTME was better at preserving male urinary function. Overall, both techniques demonstrated only mild postoperative functional impairment.
Effects of coordinated operation management of HVDC links and PSTs on the redispatch in a Central European case study
Authors: Polster Stefan , Renner Herwig 
Published: September 2021

AbstractIn this paper, the effects of coordinated operation management of embedded HVDC links and phase shifting transformers on the optimal redispatch costs and volumes are examined. The underlying optimization problem, including these power flow controlling devices, is formulated for linear optimization using DC load flow equations. The evaluation is based on the results of a year-round simulation of the expected energy market and network situation of the ENTSO-E region of the year 2025. The results highlight the need for coordinated operation management of PFCs since uncoordinated operation management increases the accruing redispatch costs.
Performance assessment of meta-heuristics for composite layup optimisation
Authors: Jalili Shahin , Khani Reza , Maheri Alireza , Hosseinzadeh Yousef 
Published: September 2021

AbstractThis paper investigates the performance of several meta-heuristic algorithms, including Particle Swarm Optimisation (PSO), different variants of Differential Evolution (DE), Biogeography-Based Optimisation (BBO), Cultural Algorithm (CA), Optics-Inspired Optimisation (OIO), and League Championship Algorithm (LCA), for optimum layup of laminated composite plates. The study provides detailed Pseudo codes for different algorithms. The buckling capacity maximisation of a 64-layer laminated composite plate under various load scenarios has been considered as the benchmark problem, in which the design variables are the stacking sequences of layers. A Deep Statistical Comparison (DSC) method is employed to rank the performance of different algorithms. The DSC uses a nonparametric two-sample Kolmogorov-Smirnov test to conduct the performance comparisons between the algorithms. The overall performance rankings obtained from the DSC suggest that the LCA, OIO, and PSO algorithms perform remarkably better in comparison to other algorithms. The comparisons provide some interesting conclusions on the performance of different algorithms.