bluuebunny/crossref_metadata_2025_split huggingface dataset:
RESPON GENERASI MILENIAL PADA KONTEN DAKWAH YOUTUBE AGUS MUHAMMAD IQDAM (ANALISIS NETNOGRAFI)
Authors: Hasyim Iskandar  , Binti Amanah  
Published: December 2024

Modern communication tools have made it possible to spread da'wah via the internet more creatively and interestingly. An example is the use of YouTube by the Sabilu Taubah Ta'lim Council to spread Agus Muhammad Iqdam's preaching through the Gus Iqdam Official channel. Since its founding on April 1 2020, this channel has grown rapidly with 706 thousand subscribers and 228 videos. This assembly aims to approach street children and criminals in a carefree and non-formal atmosphere, providing a space for them to learn and strengthen their religious knowledge.
To study more deeply related to this research, all data will be analyzed using the netnography analysis method, to find out and understand deeply the meaning, for example, of human practices, culture, works of art and texts, in the netnography method (Digital Ethnography Method in Modern Society), using theory from Rulli Nasrullah Virtual Ethnography Research (Communication, Culture and Sociotechnology Research on the Internet). Netnographic research was chosen because this research uses digital content objects, and intends to reveal reactions that are part of online culture that require online audience interaction on the internet. Researchers will make direct observations on the Gus Iqdam Channel by analyzing the text of the comment column which shows responses regarding his preaching via the YouTube account.
This research found that the Gus Iqdam Official YouTube channel received a predominance of positive comments on preaching content with the theme "Live Video Routine Tuesday Evening Majlis Sabilu Taubah Blitar" on December 4 2023, which managed to collect 1000 comments. These comments focus on appreciation of the story of the Prophet and his morals as conveyed, as well as the involvement of entertaining artists. Gus Iqdam conducts da'wah with a unique approach tailored to the interests of the audience, featuring famous figures such as artists or public figures, and accepting all groups without discrimination. This makes the recitations attractive to local congregations and from outside the area. Gus Iqdam tries to keep the content fresh and interesting, using a relaxed and elegant appearance style. Although there are suggestions to pay more attention to audiences who do not understand Javanese, this research emphasizes the importance of paying attention to feedback from netizens to improve one's preaching and establish better communication. However, the preaching content with the theme "Harlah Ke 5 Day 1 with Denny Caknan, Ki Rudi Gareng, Abah Kirun, Cak Percil" on February 16 2024, although popular, caused controversy with many negative comments and insults. Gus Iqdam did not deactivate negative comments, which triggered mixed responses. Despite this, his content still gets a lot of support and positive comments because of Gus Iqdam's personal charm and the support of sponsors who help each of his content and events.
PERAN LITERASI KEUANGAN DALAM MENINGKATKAN INKLUSI KEUANGAN BAGI IBU RUMAH TANGGA YANG MENGELOLA UMKM
Authors: Risdayanti Risdayanti , Haedar Haedar , Syafitri Azifah 
Published: December 2024

Inklusi keuangan dan literasi keuangan merupakan dua faktor penting yang dapat meningkatkan kesejahteraan perekonomian masyarakat, khususnya ibu rumah tangga yang menjalankan usaha mikro, kecil, dan menengah (UMKM). Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh literasi keuangan terhadap inklusi keuangan ibu rumah tangga yang menjalankan UMKM. Penelitian ini menggunakan pendekatan kualitatif dengan desain studi kasus. Data dikumpulkan melalui wawancara mendalam terhadap beberapa ibu rumah tangga pelaku UMKM dianalisis menggunakan teknik analisis tematik. Penelitian menunjukkan bahwa rendahnya literasi keuangan menghambat akses terhadap layanan keuangan formal. Ibu rumah tangga dengan literasi keuangan yang tinggi cenderung memiliki akses yang lebih mudah terhadap produk keuangan formal. Hasil ini menyoroti pentingnya pelatihan literasi keuangan yang lebih formal dan terstruktur untuk meningkatkan inklusi keuangan bagi ibu rumah tangga yang menjalankan UMKM. Oleh karena itu, penelitian ini memberikan kontribusi penting bagi pengembangan program yang lebih efektif untuk meningkatkan literasi keuangan.
Multidimensional Model of Library Space in the Convergence Era: Foreign Scientific Discourse
Authors: Sidyna Oleksandr 
Published: December 2024

The aim of the article is to study a multidimensional model of library space in the convergence era, presented within the framework of modern foreign scientific discourse.
Research methods. In this article, a set of approaches and methods are applied: discourse as a methodologically important concept in researching studies and approaches to library space in foreign science; systematic approach, through the prism of which a library is positioned as an autonomous system; structural and functional approach, which helped to reveal the dimensions of library space, and interpret it as a part of common socio-cultural environment; substantive approach, which pictured peculiarities of restructuring library space in the multidimensionality direction (mutual enrichment of virtual, physical and social spaces); methods of analysis and synthesis, descriptive method.
Scientific novelty. For the first time, the model of multidimensional space of the library in the convergence era is considered as an important stage in the development of the Library 4.0 concept.
Main conclusions. Presented in this article, the model of the multidimensional space of the modern library, which consists of three subspaces (physical, social and digital (virtual)), is an important stage in the development of the Library 4.0 concept. It implies the convergence of the mentioned above subspaces, each of which complements and enriches the other one. An analysis of foreign scientists’ works proves that many of these researchers support the idea of the convergence of these subspaces only with a bias toward digitalisation, which devalues the physical and social spaces of the library. That is why the model of the multidimensional space of the modern library provides for convergent regulatory processes that balance physical, social and digital subspaces in such a way that allows preserving the idea of the library as a basic educational, social and communicative structure that stimulates the development of all structural elements of the personality in the 21st century.
Assessment of impact of COVID-19 on temporomandibular disorders and its prevalence in Central India post-COVID: a survey
Authors: Srivastava Rajeev , Jain Roshni , Makker Raveena , Razdan Rahul , Patel Vedant , Khandelwal Sourabh 
Published: December 2024

BackgroundTemporomandibular disorders (TMD) are characterized by pain and dysfunction affecting the temporomandibular joints and surrounding muscles. TMD prevalence in the general population is estimated at 5–12%, with psychological factors like anxiety and depression contributing to its onset and progression. TMD's impact extends to various health conditions and psychological distress. The COVID-19 pandemic exacerbated musculoskeletal pain, with studies indicating a heightened prevalence of TMD among those affected.ObjectiveThe objective of this study was to evaluate the prevalence and impact of temporomandibular disorders (TMD) in individuals affected by COVID-19 in Central India.Material and methodsThis observational, cross-sectional study was conducted in Central India from January to April 2024 and included 400 patients attending the hospital OPD. Participants were selected via convenience sampling, with a focus on those affected by COVID-19. Data was collected through a pre-tested, self-administered structured questionnaire, validated through expert consultation and a pilot study. Statistical analysis was performed using SPSS 21.0, assessing data distribution and significance.ResultsAmong participants, 24.5% were aged 56 years or above, with 120 (30%) diagnosed with TMD. Of these, 46.67% were diagnosed post-COVID, with jaw pain being a prominent symptom. The pandemic worsened symptoms for 55.56% of participants, with many attributing this to increased stress. A significant number of participants sought medical help during the pandemic, but satisfaction with treatment options was low. Challenges such as increased pain and difficulty eating were reported, and most participants faced additional health issues post-COVID.ConclusionsThe study reveals that TMD diagnosis and symptoms were notably affected by COVID-19, with increased pain and functional challenges reported. Despite seeking treatment, participants expressed dissatisfaction with available options, highlighting need for enhanced management and support strategies for TMD in the context of post-COVID health challenges.
ANALISIS BIBLIOMETRIK: TREND PENELITIAN ETNOMATEMATIKA DI JEMBER PADA MATERI GEOMETRI
Authors: Panglipur Indah Rahayu 
Published: December 2024

This research aims at bibliometric analysis so that data can be obtained that can be used as a reference regarding the diversity of ethnomathematics in geometric concepts that have been explored through research to be developed in mathematics learning. The novelty obtained from this research is that it is able to provide an overview and reveal the trend position of ethnomathematics research on geometry material in Jember. The benefit obtained can be used as a reference for learning process activities carried out at school. This research uses bibliometric visualization and bibliometric analysis to provide a structural overview of the field of qualitative research. Bibliometrics uses the Publish or Perish (PoP) and VOSviewer applications to obtain a research trend database. The research results show that the concept of geometry is found in several publications related to ethnomathematics in Jember. Applications of concepts related to this research are triangles, symmetry, parallel lines, straight lines, curved lines, and applied to batik motifs.
Perfluorinated compounds linked to central precocious puberty in girls during COVID-19: an untargeted metabolomics study
Authors: Li Haidan , Xie Manfang , Luo Hailing , Cai Yuhua , Liu Li , Li Hongai , Hai Yuanping , Ren Yi , Xue Jing , He Xiaojie , Huang Xiaoyan , Xiang Wei 
Published: December 2024

Background and objectiveThe incidence of central precocious puberty (CPP) in girls increased significantly during the COVID-19 pandemic. This study aimed to explore the impact of perfluorinated endocrine disruptors on CPP through metabolomics analysis in girls from Hainan Province, China.MethodsSerum samples from 100 girls with CPP and 100 healthy controls were collected. Untargeted metabolomics profiling was performed using ultra-high performance liquid chromatography coupled with quadrupole-Exactive Orbitrap mass spectrometry (UHPLC-Q-Exactive-Orbitrap-MS). Differentially expressed metabolites (DEMs) were screened, and pathway enrichment analysis was conducted.ResultsPrincipal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) revealed distinct metabolic profiles between the CPP and control groups. A total of 511 metabolites were identified, including 296 up-regulated DEMs and 255 down-regulated DEMs. Three perfluorinated compounds—PFSM-perfluoroalkyl_sulfonamide_Me, PFSM-FSAA, and PFCA-unsaturated—were significantly upregulated in the CPP group. KEGG pathway enrichment analysis suggested the involvement of multiple pathways in the CPP process regulated by these compounds.ConclusionsPerfluorinated compounds may promote CPP in girls by interfering with various pathways and affecting the hypothalamic-pituitary-gonadal axis function. This study highlighted the need for further research and public health measures to address environmental endocrine disruptors.
Novel rhesus macaque immunoglobulin germline genes identified by three sequencing approaches
Authors: Guo Yicheng , Waltari Eric , Lu Hong , Sheng Zizhang , Wu Xueling 
Published: December 2024

IntroductionRhesus macaques have long been a focus of research for understanding immune responses to human pathogens due to their close phylogenetic relationship with humans. As rhesus macaque antibody germlines show high degrees of polymorphism, the spectrum of database-covered genes expressed in individual macaques remains to be determined.MethodsHere, four rhesus macaques infected with SHIVSF162P3N became a study of interest because they developed broadly neutralizing antibodies against HIV-1. To identify the immunoglobulin heavy chain V-gene (IGHV) germlines in these macaques, we applied three sequencing approaches – genomic DNA (gDNA) TOPO sequencing, gDNA MiSeq, and messenger RNA (mRNA) MiSeq inference with IgDiscover, and illustrated the detection power of each method.ResultsOf the 197 new rhesus IGHV germline sequences identified, 116 (59%) were validated by at least two methods, and 143 (73%) were found in at least two macaques or two sample sources. About 20% of germlines in each macaque are missing from the current database, including a subset frequently expressed. Overall, gDNA MiSeq determined the greatest number of germline sequences, followed by gDNA TOPO sequencing and mRNA MiSeq inference by IgDiscover, with IgDiscover providing direct evidence of allele expression and usage.DiscussionOur interdisciplinary study sheds light on germline sequencing, enhances the rhesus IGHV germline database, and highlights the importance of germline sequencing in rhesus immune repertoire studies.
Alterations in the gut microbiome and metabolism with doxorubicin-induced heart failure severity
Authors: Wang Qian , Liu Meihua , Liu Tianpei , Li Long , Wang Chenyang , Wang Xiaolin , Rong Shuling , Zhou Xuedong 
Published: December 2024

ObjectiveThis study aimed to explore the changes in gut microbiota and its metabolites in different pathophysiological stages of doxorubicin (DOX)-induced heart failure (DIHF) and the relationship between gut microbiota and metabolites in various degrees of DIHF.Materials and methodsC57BL/6 J mice were injected intraperitoneally with 5 mg/kg of DOX once a week for 5 consecutive weeks. At different times after injection, the cardiac function and histopathological analysis was conducted, the serum levels of creatine kinase (CK), CK-MB, lactic dehydrogenase, and cardiac troponin T were determined. 16S rRNA gene sequencing of feces and the nontargeted metabolomics analysis of serum were performed. Multi-omics analyses were used to explore the correlation between gut microbiota and serum metabolites.ResultsThe results showed that DOX caused cardiac contractile dysfunction and left ventricular (LV) dilation. The levels of myocardial enzymes significantly increase in 3 and 5 weeks after DOX injection. DOX-treated mice showed significant differences in the composition and abundance of gut microorganisms, and the levels of serum metabolites at different times of treatment. Multi-omics analyses showed that intestinal bacteria were significantly correlated with the differential metabolites. Some bacteria and metabolites can be used as biomarkers of DIHF (AUC &gt; 0.8). KEGG analyses showed the involvement of different metabolic pathways in various degrees of DIHF.ConclusionMarked differences were found in the composition and abundance of gut microorganisms, the levels of serum metabolites and metabolic pathways in different degrees of DIHF. The intestinal bacteria were significantly correlated with differential metabolites in different degrees of DIHF. The gut microbiota may serve as new targets for the treatment of DIHF.
Effects of different exercise types on balance function in healthy older adults and Parkinson’s patients: a systematic review
Authors: Guo Xu Bin , Tang Lu 
Published: December 2024

ObjectiveThis study aims to compare the effects of Tai Chi, yoga, and resistance training on balance function in healthy elderly individuals and patients with Parkinson’s disease (PD). Given the well-documented benefits of these three exercise types in enhancing balance and motor function, it is crucial to assess their differential impacts.MethodsA comprehensive search was conducted across PubMed, Web of Science, Scopus, and Cochrane Library databases through December 2023. Articles were selected based on predefined criteria, screened, and evaluated by two independent researchers who also extracted study characteristics. The risk of bias was assessed using the Cochrane risk of bias tool. The primary outcome measures were the Berg Balance Scale and the Timed Up and Go test, while the secondary measure was the Unified Parkinson’s Disease Rating Scale Part III. A random effects model was employed, and heterogeneity was measured using the I2 statistic.ResultsOf the 21 studies reviewed, 9 focused on healthy older adults and 12 targeted individuals with PD. The meta-analysis showed that Tai Chi, yoga, and resistance training significantly improved balance in patients with PD compared to control groups (p &lt; 0.00001). Resistance training was most effective in enhancing dynamic balance in healthy older adults (p = 0.003), while Tai Chi had the most significant impact on balance improvement in PD patients (p &lt; 0.00001). Notably, interventions conducted three to four times per week, each lasting 50–60 min and continued over 12 weeks, yielded the most substantial balance improvements.ConclusionComparative analyses demonstrate that Tai Chi, yoga, and resistance training significantly enhance balance and motor function. Specifically, resistance training markedly improves dynamic balance in healthy elderly individuals, while Tai Chi shows pronounced improvements in motor function and balance for PD patients. Optimal balance improvements are achieved by performing interventions three to four times per week, with each session lasting 50–60 min, over 12 weeks.Systematic review registrationhttps://inplasy.com/, identifier INPLASY202470042.
Paired nerve stimulation with selective compensation effect
Authors: Leukhin Alexey , Mikhailova Yuliya , Masaev Dinar , Belov Grigorii , Toschev Alexander , Fatykhova Elsa , Vallverdú Jordi , Talanov Max 
Published: December 2024

BackgroundIn this study we investigate the selective compensation of paired peripheral nerves in healthy humans, focusing on distinct axonal conduction velocities in different fibre types. Using paired associative stimulation (PAS) with adjustable parameters, we aimed to modulate and compensate for neuronal activity along the median nerve.MethodsSix healthy volunteers (3 male, 3 female, aged: 22–49) participated in the current study. We conducted 30 experiments with the following protocol. A pair of pulses with the following parameters were applied to each volunteer: amplitude, pulse width and inter-pulse delay was generated by the dual-core programmed microcontroller STM32H745xI/G while values were set by one-board computer Jetson Nano. The microcontroller provided a pair of pulses to the DAC that applied it to nerve stimulation sites via a stimulator. During experiments, we used the following ranges: (a) current amplitudes [0–20mA], (b) pulse width [250–500 μs] and (c) delays [50–250 μs]. As the measurement of the stimulation effectiveness, we used the finger's contraction angles.ResultsOur findings reveal a significant selective compensation (inhibitory) effect over the motor responses, demonstrated through variations in finger displacement angles. By optimizing individual parameters-pulse width, inter-pulse delay, and compensatory currents—we successfully induced motor response compensation effects. Notably, consistent compensatory effects were observed across all volunteers using a pulse width of (250 μs) and an inter-pulse delay of (50 μs).DiscussionThese results highlight PAS's potential for developing non-invasive neuromodulation devices. However, further research is required to evaluate its efficacy in individuals with spasticity and upper motor neuron deficits.
The bioinformatics analysis and experimental validation of the carcinogenic role of EXO1 in lung adenocarcinoma
Authors: Sun Bohao , Zhang Jing , Wang Nan , Zhang Zhirong , Wu Yichen , Xie Mengzhen , Peng Yanmei , Ye Yifan , Jiang Zhaochang , Wei Shumei 
Published: December 2024

BackgroundExonuclease 1 (EXO1), a protein involved in mismatch repair and recombination processes, has been identified as a prognostic biomarker in lung adenocarcinoma (LUAD). Nevertheless, its role in LUAD progression remains elusive. This study seeks to elucidate the functional significance of EXO1 in LUAD and evaluate its potential as a therapeutic target.Materials and methodsPatient RNA-seq and clinical data were acquired from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Subsequently, a protein-protein interaction (PPI) network was constructed using differentially expressed genes (DEGs) to identify pivotal genes. Validation of the expression of signature genes was carried out through quantitative real-time PCR (qRT-PCR). Additionally, the association between EXO1 expression and clinical data was investigated. Immunohistochemistry was utilized to assess EXO1 expression in 93 cases of invasive pulmonary adenocarcinoma. Finally, cellular functional assays were conducted to investigate the impact of EXO1 on LUAD cells.ResultsTen key molecules (PBK, ASPM, NCAPG, EXO1, MKI67, RRM2, AURKA, DLGAP5, UBE2C, and CDC6) exhibited significantly elevated expression levels in LUAD tissues. Moreover, elevated levels of EXO1 gene expression correlated strongly with advanced T, N, and M stages and were significantly associated with immune cell infiltration in LUAD. Furthermore, marked increases in EXO1 protein expression were observed in patients diagnosed with invasive pulmonary adenocarcinoma. Notably, patients diagnosed with invasive pulmonary adenocarcinoma who exhibited elevated EXO1 expression levels exhibited increased lymph node metastasis, pleural invasion, poor tumor differentiation, and advanced clinical stage. Additionally, this study employed wound healing assay and CCK-8 cell proliferation assays to investigate the significant role of EXO1 in promoting the growth and migration of lung adenocarcinoma cells.ConclusionsThis study identified ten hub genes associated with the initiation and progression of LUAD. Additionally, EXO1 may serve as a prognostic marker for LUAD patients, offering new perspectives for clinical treatments.