bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Wellbeing to Addiction: The Influence of Inclusive Beauty Brands on People With Physical Disabilities
Authors: Nassereddine Yaman , Ramadan Zahy , Farah Maya F. 
Published: January 2025

ABSTRACTMany industries today acknowledge the unique needs of consumers with physical disabilities. The beauty industry, in particular, has been developing new offerings to cater to this specific market. This study aims to examine the effects of using inclusive beauty products on the psychological wellbeing of people with physical disabilities as well as on brand addiction. The study follows an exploratory qualitative approach. Data were collected from 215 online reviews and in‐depth interviews with 24 consumers with different types of physical disability alongside 14 beauty and marketing experts. The study reveals that psychological wellbeing is the primary motivation for consumers with physical disabilities to use beauty products. However, over time, a strong emotional connection with these brands can form, potentially leading to addictive behaviors. To avoid brand addiction that could harm their emotional and financial wellbeing, beauty companies need to gain deeper insights into their customers, particularly those in vulnerable groups, and focus on creating effective marketing and advertising strategies to raise awareness among them. This research closely aligns with Sustainable Development Goal 10, which aims to create a more inclusive and equitable society.
Core Outcome Set and Unique Outcomes of Nursing Interventions for Women With Lactational Mastitis: A Mixed Methods Study
Authors: Lv Yun‐Peng , Lin Ke‐Ke , Zhou Fen , Fan Ying‐Yi , Mu Xiao‐Ying , Yuan Ting , Wang Yu‐Xi 
Published: January 2025

ABSTRACTAimsTo develop the core outcome set and identify unique outcomes for the three stages and five types of nursing interventions, respectively, in lactational mastitis.DesignA mixed methods study.MethodsA systematic literature search, four semi‐structured interviews for key stakeholders, two rounds of Delphi surveys and two online consensus meetings were conducted.ResultsThirty‐one nursing outcomes were derived from the systematic review (literature research from January 2019 to December 2021) and semi‐structured interviews in 2022. Six A‐category nursing outcomes and 19 B‐category nursing outcomes were determined after Dephi survey and provided in consensus meeting in 2023. The consensus meetings resulted in the agreement on seven core outcomes: Pain Level, Breast Establishment: infant, Breast Establishment: maternal, Breast Maintenance, Client satisfaction: care, Sleep, and Family Support during Treatment. Specifically, the unique outcomes for the three stages were identified as Breastfeeding Maintenance, Infection Severity and Wound Healing: Primary Intention, respectively. The unique outcomes for the five interventions included Pain level, Infection Severity, Wound Healing: Primary Intention, Comfort and Knowledge: breastfeeding, respectively.ConclusionBased on an evidence‐based, consensus‐driven approach, the core outcome set incorporates the perspectives of key stakeholders. It is recommended that all core outcomes be reported in both lactational mastitis nursing research and clinical quality control and audit. Unique outcomes should be reported based on the stages of lactational mastitis and types of interventions.ImpactThe core outcome set and unique outcomes developed by our study could provide nursing researchers and clinical practitioners with sensitive outcomes for lactational mastitis, while also promoting standardisation. Utilising these outcomes could enhance comparability among studies, reduce reporting bias and promote standardised evaluation of practice effectiveness.Reporting MethodFindings are reported per Core Outcome Set‐STAndards for Reporting: COS‐STAR Statement.Patient or Public ContributionNone.Trial Registration
https://www.comet‐initiative.org/Studies/Details/1650
A Nurse‐Initiated Protocol for Interprofessional Management of Changed Behaviours in Hospital Patients With Dementia and/or Delirium: A Modified e‐Delphi Study
Authors: Graham Frederick A. , Ossenberg Christine , Henderson Amanda 
Published: January 2025

ABSTRACTAimTo develop a nurse‐initiated protocol for early ward‐based interprofessional coordination and formulation of person‐centred care plans to assist in point‐of‐care management of behaviour in older patients on general hospital wards.DesignA modified e‐Delphi method was employed to establish expert consensus.MethodMultidisciplinary acute‐care experts experienced in hospital care of patients with dementia and/or delirium in Australia were recruited by email from 35 professional networks. Three online survey rounds were planned. The first sought free‐text comments on point‐of‐care practices. The following rounds sought expert ratings for subsequently developed protocol components. The study occurred between January and June 2023.ResultsFifty‐three experts participated (eight completed all rounds). Existing practices, opportunities and barriers were established in round one (n = 32), informing development of three multicomponent stages: (1) a bundle of bedside care comprising generic person‐centred approaches, (2) a stepped‐care workflow redirecting multidisciplinary teams to adopt an interprofessional approach to formulating individualised behavioural‐care and (3) a one‐page Behaviour Support Plan template. Content Validity Index scores for all items in round two (n = 29) were 0.89–0.96, meeting a priori consensus criteria, and negating the need for a third round.ConclusionTo improve outcomes for older hospital patients with changed behaviours, a multicomponent protocol for timely interprofessional formulation of point‐of‐care Behaviour Support Plans was established through expert panel consensus.ImpactManagement of patient behaviours has resided almost solely with nursing, ignoring the potential inherent in ward‐based multidisciplinary teams. A pragmatic procedure for initiating early interprofessional support to nurses' management of behaviours may potentially improve care, safety and outcomes for patients and staff alike. Ready for feasibility testing in hospitals, the protocol capitalises on existing multidisciplinary resources.Reporting MethodThe study is reported in accordance with the Guidance on Conducting and Reporting Delphi Studies (CREDES) recommendations.Patient or Public ContributionNo patient or public contribution.
Quantile Regression Estimation for Poisson Autoregressive Models
Authors: Sheng Danshu , Wang Dehui 
Published: January 2025

ABSTRACTEstimating conditional quantiles plays a crucial role in modern risk management and other various applications. However, the quantile regression (QR) estimation of Poisson autoregressive (PAR) models, count‐type models, remain an unresolved challenge. In this study, we propose a novel approach that employs a jittering smoothing method and a novel transformation strategy to convert this complex problem into an easily implementable quantile regression problem for continuous‐type regression models. The asymptotic theory of the estimator is derived under some regularity conditions and the applications to four popular and classical PAR models are considered. Additionally, a novel ‐step prediction method (‐QRF) is developed to forecast the ‐step conditional distribution. The finite sample performance of the method is examined, and its advantages over existing methods are illustrated by simulation studies and an empirical application to the daily stock volume dataset of Technofirst.
Analyzing the Utilization of Simulation Within Public Health Nursing: A Systematic Review
Authors: Manning Lucas , Pauley Jessica , Koehler Echo 
Published: January 2025

ABSTRACTBackgroundPublic and community health nursing curriculum falls short in providing an assessment of student achievement through competency‐based education. The aim of this evidence‐based practice research was to demonstrate a lack of simulation use as a pedagogical means for the assessment of student achievement of community/public health nursing competencies (C/PHN) in prelicensure nursing programs.SampleA systematic review yielded 10 articles.MethodQualitative Comparative Analysis (QCA) was employed for theme analysis of a systematic review. A crosswalk was created aligning themes from the systematic review to the C/PHN core competencies relevant to public health nursing developed by the Quad Council Coalition (QCC) (2018).ResultsThree themes were identified from the systematic review that aligned with five of the eight domains from the C/PHN. Gaps in clinical and curricular exposure to specific public/community health concepts were identified.ConclusionSimulation has the potential to incorporate various public health concepts, including those related to social determinants of health.
Transgenic Cynodon dactylon overexpressing CdPIF4 alters plant development and cold stress tolerance
Authors: Xu Xiao , Liu Xiaoyan , Yin Yanling , Fan Shugao , Qi Yunjie , Xing Yiquan , Fu Jinmin 
Published: January 2025

AbstractBermudagrass [Cynodon dactylon (L.) Pers.] is widely used for soil remediation, livestock forage, and as turfgrass for sports fields, parks, and gardens due to its resilience and adaptability. However, low temperatures are critical factors limiting its geographical distribution and ornamental season, even preventing its safe overwintering. PHYTOCHROME‐INTERACTING FACTOR 4 (PIF4) acts as a hub transcription factor, not only regulating various light responses but also integrating multiple external stimuli to improve plant productivity and architectural adaptation under adverse stress conditions, which makes it potential as a target gene. In this study, we cloned and characterized the CdPIF4 genes in bermudagrass. Expression analysis revealed that it is predominantly expressed in leaves and is regulated by photoperiod and cold stress. Using Agrobacterium‐mediated genetic modification, we successfully generated CdPIF4a‐overexpressing bermudagrass lines. Under cold stress at 4°C, these transgenic plants demonstrated enhanced cold tolerance, as indicated by higher relative water content, reduced membrane damage, and lower levels of lipid peroxidation levels. Photosynthetic analysis revealed that CdPIF4a‐overexpressing plants exhibited higher light energy capture and transfer efficiency at this low temperature, with less energy loss. Additionally, they showed higher antioxidant enzyme activity and lower levels of reactive oxygen species levels. The responsive regulation of cold stress‐related genes further validated the role of the CdPIF4a gene in enhancing cold tolerance. This study elucidates that CdPIF4 enhances cold tolerance in bermudagrass through physiological and molecular mechanisms, offering new insights and valuable genetic resources for advancing cold resistance research in bermudagrass and other grass species.
Pediatric Endocrinology Education Among Trainees: A Scoping Review
Authors: Alshammri Fahd , Abdulshakour Muhammed , Chen Lucy , Sheppard Rebekah , Kearney Josie , Petropoulos Jo‐Anne , Bilgic Elif 
Published: January 2025

ABSTRACTIntroductionPediatric endocrinology education is a fundamental part of all pediatric endocrinology training. Hence, understanding the current methods used for training learners on skills required and understanding methods or topics that may be underexplored could help improve the quality of training.ObjectiveThis study aims to explore training and assessment strategies used in pediatric endocrinology training across medical education programs through a scoping review.MethodsSearch strategy was developed with a librarian, and bibliographic databases (e.g., MEDLINE and EMBASE) were searched from January 2005 to July 2024. Pilot screenings ensured consistent inclusion/exclusion decisions among reviewers. Full‐text articles were included if they were related to pediatric endocrinology education and focused on medical learners.ResultsWe included 45 of 5814 sources of evidence for data extraction. Majority focused on knowledge of Type 1 and Type 2 diabetes and diabetes ketoacidosis (N = 18), followed by differences in sex development and pubertal assessment (N = 12). The most frequently used training method was through didactics. Additionally, the most frequently used assessment measures included knowledge tests (N = 25). Also, a limited number of studies targeted obesity (N = 2), gender care (N = 3), thyroid (N = 1) and hypoglycaemia (N = 1), and no studies targeted common topics such as bone health and adrenal insufficiency.ConclusionThis review reveals the current emphasis on diabetes‐related topics and traditional teaching in pediatric endocrinology education. It suggests a need for more innovative methods, like simulation‐based learning and varied assessment techniques, to better equip trainees. Addressing these gaps can improve trainee confidence, patient care, and health outcomes for children with endocrine disorders.
Antiphase Trunk Motion Reduces Sway Velocity and Ankle Torque During Quiet Stance
Authors: Creath Robert A. , Venezia Veronica , Hinkley Benjamin , Sharp Niclas , Sciamanna Christopher 
Published: January 2025

The purpose of this study was to determine the role of antiphase trunk motion during quiet stance while maintaining constant visual and support surface conditions. Eyes-open quiet stance trials were performed on a firm support surface while wearing a rigid hip-knee orthotic brace that reduced antiphase trunk motion. Amplitude spectral density, coherence, and cophase were compared for hip-locked, hip-unlocked, and no-brace conditions. Amplitude spectral density calculations showed that trunk and leg sway velocities, and ankle torque (AT) decreased when antiphase trunk sway was allowed. Coherence and cophase estimates identified in-phase trunk-legs sway below 1 Hz and antiphase at higher frequencies. Legs-AT cophase calculations showed that the legs lagged the application of AT at all frequencies, while trunk-AT cophase showed the trunk lagged AT below 1 Hz and led AT at higher frequencies. The results demonstrate that antiphase trunk sway helps reduce sway velocity and AT. Furthermore, the trunk-leading cophase relationship with AT showed that antiphase trunk motion occurred before AT was applied. This implies that antiphase trunk motion facilitates changes in sway direction and helps regulate sway velocity. The results have significant implications for predicting postural control deficiencies due to injury, disease, and aging.
Using Arts-Based Methods to Support Embodied Research With Children and Young People in Physical Education
Authors: Alfrey Laura , Quarmby Thomas , Hooper Oliver 
Published: January 2025

Purpose: This paper responds to two questions: (a) What are the possibilities and tensions associated with using arts-based methods to support research with children and young people in physical education (PE)? and (b) How can the pedagogical attributes of embodiment in PE inform research with children and young people? Method: Three PE researchers reflected on their use of arts-based methods with children and/or young people. The resulting reflections were analyzed inductively and deductively. Findings: Arts-based methods can (a) foreground youth voice and agency, (b) generate embodied and rich data, and (c) enhance dissemination and impact. The three researcher reflections exemplified the pedagogical attributes of embodiment, suggesting the attributes have utility in PE research. Conclusion: If researchers are to extend the field of PE, we need to extend our methodological repertoire to include methods that reflect its embodied nature, and the lives of the participants we are striving to better understand.
Figure 7 from Targeted Degradation of SOS1 Exhibits Potent Anticancer Activity and Overcomes Resistance in KRAS-Mutant Tumors and BCR–ABL–Positive Leukemia
Authors: Luo Ziwei , Lin Chencen , Yu Chuwei , Yuan Changxian , Wu Wenyong , Xu Xiaowei , Sun Renhong , Jia Yan , Wang Yafang , Shen Jie , Wang Dingyan , Wang Sinan , Jiang Hualiang , Jiang Biao , Yang Xiaobao , Xie Chengying 
Published: January 2025

<p>Combination of SIAIS562055 and TKIs synergistically inhibits the growth of CML xenografts <i>in vivo</i> and enhances cell death in primary samples from patients with CML. <b>A–D,</b> K562-xenografted mice received vehicle, SIAIS562055 (30 mg/kg/day), imatinib (100 mg/kg/day), or their combination; then, relative tumor volumes (<b>A</b>), tumor weights (<b>B</b>), photo of tumors (<b>C</b>), and mice body weights (<b>D</b>) were determined at indicated times. Data are presented as mean ± SEM, <i>n</i> = 5. <b>E,</b> Western blot analysis of SOS1, pERK, and pSTAT5 in K562 xenograft tumors after treatment with vehicle, SIAIS562055, imatinib, or their combination. Data are shown as mean ± SEM, <i>n</i> = 5. <b>F,</b> Cell viability of three primary BCR–ABL<sup>+</sup> samples from patients with CML treated with varying doses of SIAIS562055 or imatinib, alone or in combination, for 72 hours was assessed by CellTiter-Glo assay. Data are presented as mean ± SD, <i>n</i> = 3. <b>G,</b> Western blot analysis of the indicated proteins in primary samples from patients with CML under 24-hour exposure to SIAIS562055 or imatinib, alone or in combination. Statistical significance was assessed using two-tailed unpaired Student <i>t</i> test. *, <i>P</i> < 0.05; **, <i>P</i> < 0.01; ***, <i>P</i> < 0.001. qd, once a day.</p>
Figure 3 from Replication Stress Is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors
Authors: Kawai-Kawachi Asuka , Lenormand Madison M. , Astier Clémence , Herbel Noé , Cutrona Meritxell B. , Ngo Carine , Garrido Marlène , Eychenne Thomas , Dorvault Nicolas , Bordelet Laetitia , Song Feifei , Bouyakoub Ryme , Loktev Anastasia , Romo-Morales Antonio , Henon Clémence , Colmet-Daage Léo , Vibert Julien , Drac Marjorie , Brough Rachel , Schwob Etienne , Martella Oliviano , Pinna Guillaume , Shipley Janet M. , Mittnacht Sibylle , Zimmermann Astrid , Gulati Aditi , Mir Olivier , Le Cesne Axel , Faron Matthieu , Honoré Charles , Lord Christopher J. , Chabanon Roman M. , Postel-Vinay Sophie 
Published: January 2025

<p>PARPi and ATRi combination elicits DNA damage, replication stress, and genomic instability in DSRCT cells. <b>A–D,</b> Quantification of γH2AX (<b>A</b> and <b>B</b>) or RAD51 foci (<b>C</b> and <b>D</b>) in JN1 (<b>A</b> and <b>C</b>) or R (<b>B</b> and <b>D</b>) cells exposed to DMSO control, PARPi talazoparib (Tala), ATRi M4344, or a combination of both for 72 hours. Cisplatin was used as the positive control. A minimum of 500 nuclei was analyzed per condition. Violin plots show the absolute number of foci per nucleus. Thick line, median; thin lines, bottom and top quartiles; two-way ANOVA and <i>post hoc</i> Dunn test. <b>E</b> and <b>F,</b> Western blots of pCHK1, CHK1, pRPA2, RPA2, γH2AX, H2AX, and cleaved-PARP1 (cPARP) in JN1 (<b>E</b>) or R (<b>F</b>) cells exposed to DMSO control, PARPi talazoparib or olaparib, ATRi M4344 or AZD6738, or a combination of both for 48 hours. <b>G</b> and <b>H,</b> Representative immunofluorescence images (<b>G</b>) and quantification (<b>H</b>) of micronuclei-positive cells in JN1 cells exposed to DMSO control, PARPi talazoparib, ATRi M4344, or a combination of both for 72 hours. A minimum of 500 cells was analyzed per condition. Mean ± SD; <i>n</i> = 3; one-way ANOVA and <i>post hoc</i> Dunn test. Arrows, micronuclei. Scale bar, 20 μm. *, <i>P</i> < 0.05; **, <i>P</i> < 0.01; ***, <i>P</i> < 0.001; ****, <i>P</i> < 0.0001; ns, not significant.</p>
Single-Cell Transcriptomics Identifies Selective Lineage-Specific Regulation of Genes in Aortic Smooth Muscle Cells in Mice
Authors: Shukla Shalabh , Jana Sayantan , Sanford Nicole , Lee Chloe Y. , Liu Li , Cheng Paul , Quertermous Thomas , Dichek David A. 
Published: January 2025

BACKGROUND:
Smooth muscle cells (SMCs) of the proximal thoracic aorta are derived from second heart field (SHF) and cardiac neural crest (CNC) lineages. Recent studies, both in vitro and in vivo, have implied relevance of lineage-specific SMC functions in the pathophysiology of thoracic aortic diseases; however, whether 2 lineage-derived SMCs have any predisposed transcriptional differences in the control aorta remains unexplored.

METHODS:

Single-cell RNA sequencing and single-nucleus assay for transposase-accessible chromatin sequencing were performed on isolated cells from the aortic root and ascending aortas of 14-week-old SHF-traced (
Mef2c-Cre

+/0

-Yfp

+/0

) and CNC-traced (
Wnt1-Cre

+/0

-Yfp

+/0

) male mice. RNA in situ hybridization was performed for spatial expression of selected differentially expressed genes (DEGs) of both lineages.

RESULTS:

Lineage stratification of SMCs in the proximal thoracic aorta was identified using antibody-based immunofluorescence staining. Single-cell RNA sequencing recognized 12 consistently upregulated DEGs (
Des
,
Tnnt2
,
Hand2os1
,
Psd
,
Gpc3
,
Meis2
,
Dcn
,
Gm34030
,
Palld
,
Nrtn
,
Lum
, and
Cfh
) in SHF-derived SMCs and 9 consistently upregulated DEGs (
Ccn5
,
Ccdc42
,
Tes
,
Eln
,
Aebp1
,
Galnt6
,
Ccn2
,
Aopep
, and
Wtip
) in CNC-derived SMCs. RNA in situ hybridization validated upregulated expressions of selective SHF-specific DEGs at the aortic root. We found SHF-derived SMCs contain a distinct, large subpopulation of SMCs that is enriched with
Des
and
Tnnt2
expressions. Single-nucleus assay for transposase-accessible chromatin analysis further confirmed higher chromosomal accessibility for upregulated DEGs of SHF-derived SMCs.

CONCLUSIONS:
The present study recognizes the presence of limited but distinct transcriptomic differences between CNC-derived and SHF-derived SMCs in the control proximal thoracic aorta.
Brain morphology normative modelling platform for abnormality and centile estimation: Brain MoNoCle
Authors: Little Bethany , Alyas Nida , Surtees Alexander , Winston Gavin P , Duncan John S , Cousins David A , Taylor John-Paul , Taylor Peter , Leiberg Karoline , Wang Yujiang 
Published: January 2025

Abstract
Normative models of brain structure estimate the effects of covariates such as age and sex using large samples of healthy controls. These models can then be applied to, for example, smaller clinical cohorts to distinguish disease effects from other covariates. However, these advanced statistical modelling approaches can be difficult to access, and processing large healthy cohorts is computationally demanding. Thus, accessible platforms with pre-trained normative models are needed. We present such a platform for brain morphology analysis as an open-source web application https://cnnplab.shinyapps.io/BrainMoNoCle/, with six key features: (i) user-friendly web interface, (ii) individual and group outputs, (iii) multi-site analysis, (iv) regional and whole-brain analysis, (v) integration with existing tools, and (vi) featuring multiple morphology metrics. Using a diverse sample of 3,276 healthy controls across 21 sites, we pre-trained normative models on various metrics. We validated the models with a small sample of individuals with bipolar disorder, showing outputs that aligned closely with existing literature only after applying our normative modelling. Using a cohort of people with temporal lobe epilepsy, we showed that individual-level abnormalities were in line with seizure lateralisation. Finally, with the ability to investigate multiple morphology measures in the same framework, we found that biological covariates are better explained in specific morphology measures, and for applications, only some measures are sensitive to the disease process. Our platform offers a comprehensive framework to analyse brain morphology in clinical and research settings. Validations confirm the superiority of normative models and the advantage of investigating a range of brain morphology metrics together.