bluuebunny/crossref_metadata_2025_split huggingface dataset:
Superstructure formation in the solid solution Sc3Pt3−xIn3 (x = 0–0.93)
Authors: Gulay Nataliya L. , Hoffmann Rolf-Dieter , Kösters Jutta , Kalychak Yaroslav M. , Seidel Stefan , Pöttgen Rainer 
Published: March 2021

Abstract
The equiatomic indide ScPtIn (ZrNiAl type, space group P

6
‾

$&#x203e;{6}$

2m) shows an extended solid solution Sc3Pt3–xIn3. Several samples of the Sc3Pt3–xIn3 series were synthesized from the elements by arc-melting and subsequent annealing, or directly in a high frequency furnace. The lowest platinum content was observed for Sc3Pt2.072(3)In3. All samples were characterized by powder X-ray diffraction and their lattice parameters and several single crystals were studied on the basis of precise single crystal X-ray diffractometer data. The correct platinum occupancy parameters were refined from the diffraction data. Decreasing platinum content leads to decreasing a and c lattice parameters. Satellite reflections were observed for the Sc3Pt3–xIn3 crystals with x = 0.31–0.83. These satellite reflections could be described with a modulation vector

(

1
3

,

1
3

,
γ

)

$\left(\frac{1}{3},\frac{1}{3},\gamma \right)$

(

γ
=

1
2

$\gamma =\frac{1}{2}$

c* for all crystals) and are compatible with trigonal symmetry. The interplay of platinum filled vs. empty In6 trigonal prisms is discussed for an approximant structure with space group P3m1.
Predator-dependent transmissible disease spreading in prey under Holling type-II functional response
Authors: Ghosh Dipankar , Santra Prasun K. , Elsadany Abdelalim A. , Mahapatra Ghanshaym S. 
Published: March 2021

Abstract
This paper focusses on developing two species, where only prey species suffers by a contagious disease. We consider the logistic growth rate of the prey population. The interaction between susceptible prey and infected prey with predator is presumed to be ruled by Holling type II and I functional response, respectively. A healthy prey is infected when it comes in direct contact with infected prey, and we also assume that predator-dependent disease spreads within the system. This research reveals that the transmission of this predator-dependent disease can have critical repercussions for the shaping of prey–predator interactions. The solution of the model is examined in relation to survival, uniqueness and boundedness. The positivity, feasibility and the stability conditions of the fixed points of the system are analysed by applying the linearization method and the Jacobian matrix method.
Anticancer Cardenolides from the aerial parts of Calortopis procera
Authors: Sweidan Nuha , Esawi Ezaldeen , Ismail Mohammad , Alshaer Walhan 
Published: March 2021

Abstract
Column chromatography (CC) analysis of methanol and butanol extracts of the aerial parts of Calortopis procera as well as the methanol extract of its latex, led to the isolation of 8 cardenolides, of which the structures were elucidated by NMR and HRESIMS spectroscopy. They also revealed several triterpenes and flavonoid glycoside. Based on the antiproliferative activity reported for cardenolides, the activity of calotropin and calotoxin was tested against two common cancer cell lines, human triple-negative breast cancer cell line (MDA-MB-231) and human lung adenocarcinoma cell line (A549). The high toxicity of the latex also encouraged performing the same test on the same cancer cell lines. The anti-proliferative activity of calotropin and calotoxin was compared to the methanol extract and the wax of the latex. The results showed that calotropin and calotoxin have significant cytotoxicity against MDA-MB-231 and A549 cell lines ranging from 0.046 to 0.072 μM compared to the methanol extract and the wax of its latex ranging from 0.47 to 58.41 μM. Moreover, the results showed lower toxicity of all treatments to the human skin fibroblasts compared to the toxicity to both MDA-MB-231 and A549 cancer cells lines except the higher toxicity of Methanolic extracts of C. procera latex to the MDA-MB-231 cells. In conclusion, C. procera is a medicinal plant with a wide spectrum of cardinolides including calotropin and calotoxin, which are promising agents for targeted cancer phytotherapy.
Simulation in der Praxis: Hindernisse überwinden
Authors: Kranz Michael , Duisberg Max , Harlacher Markus , Mütze-Niewöhner Susanne 
Published: March 2021

AbstractIndividuelle Produkte, komplexe Prozesse und hohe Produktivitäts- und Flexibilitätsanforderungen - Bedingungen, die viele Unternehmen vor große Herausforderungen bei der Planung ihrer Produktionssysteme stellen. Simulationsverfahren können hierbei unterstützen, in der Praxis sind allerdings diverse Hürden zu überwinden. Am Beispiel einer simulationsbasierten Optimierung der Maschinenbelegungsplanung des Presswerks eines Herstellers weißer Ware werden mögliche Lösungsansätze demonstriert.*)
Flussorientierte Positionierungsmethode für die Fabrikplanung
Authors: Kaucher Christian , Gessert Stephan , Erlach Klaus 
Published: March 2021

AbstractDie flussgerechte räumliche Anordnung von Funktionseinheiten ist eine Kernaufgabe der Fabrikplanung. Diese Anordnung erfolgt häufig stark materialflussdominiert und vernachlässigt dabei weitere Flussbeziehungen. Der Beitrag stellt eine flussorientierte Positionierungsmethode basierend auf der Funktions-Beziehungs-Matrix von Muther & Hales vor. Diese Positionierungsmethode ermöglicht die Berücksichtigung aller Flussbeziehungen sowie einen verbesserten und quantifizierten Vergleich von Alternativen.*)
Kompaktwickelprozess zur Herstellung verteilter Wicklungen
Authors: Halwas Maximilian , Wirth Felix , Fleischer Jürgen 
Published: March 2021

Abstract
Die Weiterentwicklung von Runddraht-Wickelverfahren zur Performancesteigerung elektrischer Antriebe stellt einen wichtigen Forschungsgegenstand am wbk Institut für Produktionstechnik des KIT dar. Im Rahmen bisheriger Arbeiten wurde in diesem Zusammenhang der neuartige Prozess des Kompaktwickelns entwickelt. Im vorliegenden Beitrag werden dieser definiert, eine erste prototypische Umsetzung des Kompaktwickelns vorgestellt sowie mögliche industrielle Anwendungen und Zukunftsperspektiven skizziert.*)
Agile Produktion elektrischer Traktionsmotoren als Antwort auf volatile Märkte und Technologien
Authors: Fleischer Jürgen , Pfund Thomas , Wirth Felix , Fraider Felix , Halwas Maximilian , Hausmann Ludwig , Wößner Wilken 
Published: March 2021

Abstract
Elektrische Traktionsmotoren nehmen – unabhängig von der Art der Elektrifizierung – eine zentrale Rolle im Mobilitätswandel ein. Volatile Rahmenbedingungen, Märkte und Technologien führen jedoch dazu, dass das Investitionsrisiko in dem Stand der Technik entsprechende Produktionssysteme mit eingeschränkter Flexibilität als hoch einzustufen ist. Vor diesem Hintergrund soll im Forschungsvorhaben AgiloDrive durch die integrierte Entwicklung modularer Produkt- und Produktionsbaukästen eine nachfrageorientierte Wandlungsfähigkeit des Produktionssystems befähigt werden.**)
Bedeutung der Robustheit von Produktionssystemen
Authors: Stockmann Christian , Winkler Herwig 
Published: March 2021

Abstract
Eine adäquate Robustheit ist in allen Produktionssystemen eine wesentliche Voraussetzung für effiziente Produktionsprozesse. Angesichts der technologischen Entwicklungen im Zuge der vierten industriellen Revolution wird davon ausgegangen, dass aufgrund der zunehmenden Digitalisierung, Automatisierung und Vernetzung heute bedeutsame Störungen stark an Einfluss verlieren werden. Somit würde sich auch eine Verbesserung der Robustheit in den Produktionssystemen einstellen. Dieser Beitrag untersucht Entwicklungen der vierten industriellen Revolution kritisch hinsichtlich ihrer Wirkungen auf die Robustheit und zeigt auf, weshalb eine hohe Robustheit auch im Zielzustand der Industrie 4.0 keine Selbstverständlichkeit sein wird.
Integration eines omnidirektionalen FTF in eine Produktionsprozesssteuerung
Authors: Rolfs Lennart , Schweers Dirk , Hoppe Nils Hendrik , Petzoldt Christoph , Shahwar Zain , Freitag Michael 
Published: March 2021

Abstract
Die Optimierung logistischer Abläufe durch Integration neuer Systeme kann mit hohem Planungs- und Inbetriebnahmeaufwand verbunden sein. Mit der neuen cloudbasierten Open Platform for Innovations in Logistics (OPIL) lassen sich Maschinen und Logistiksysteme zu einer IoT-Plattform verbinden, die durchgängig für die Optimierung, Evaluation und anschließende Produktionsprozesssteuerung herstellerunabhängig eingesetzt werden kann. In diesem Beitrag wird die Plattform durch die Integration eines omnidirektionalen FTF validiert.**)
Kinetic Analysis of Pack-Borided Gray Cast Iron
Authors: Azouani O. , Keddam M. , Allaoui O. , Sehisseh A. 
Published: March 2021

Abstract
In this work, a gray cast iron containing copper of grade EN-GJL-250 was pack-borided within the temperature range of 800°C–1,000°C with treatment times of 2–6 h. According to the X-ray diffraction analysis, the Fe2B phase has been identified over the surface of this material and the boride layer has an average thickness between 20.8 ± 2.9 and 149.1 ± 10.2 µm. The morphological aspect of the Fe2B layer was investigated with a scanning electron microscope. The regression model based on the ANOVA analysis has been established to investigate the growth kinetics of boride layers on EN-GJL-250 gray cast iron. The boron activation energies in the EN-GJL-250 cast iron were estimated as 148.03 and 147.96 kJ mol−1 by the parabolic growth law and the mean diffusion coefficient method, respectively. Furthermore, the experimental Fe2B layers’ thicknesses were in accord with the predicted values given by the regression model and the MDC method.
Angiotensin-II Modulates GABAergic Neurotransmission in the Mouse Substantia Nigra
Authors: Singh Maibam R. , Vigh Jozsef , Amberg Gregory C. 
Published: March 2021

AbstractGABAergic projections neurons of the substantia nigra reticulata (SNr), through an extensive network of dendritic arbors and axon collaterals, provide robust inhibitory input to neighboring dopaminergic neurons in the substantia nigra compacta (SNc). Angiotensin-II (Ang-II) receptor signaling increases SNc dopaminergic neuronal sensitivity to insult, thus rendering these cells susceptible to dysfunction and destruction. However, the mechanisms by which Ang-II regulates SNc dopaminergic neuronal activity are unclear. Given the complex relationship between SN dopaminergic and GABAergic neurons, we hypothesized that Ang-II could regulate SNc dopaminergic neuronal activity directly and indirectly by modulating SNr GABAergic neurotransmission. Here, using transgenic mice, slice electrophysiology, and optogenetics, we provide evidence of an AT1receptor-mediated signaling mechanism in SNr GABAergic neurons where Ang-II suppresses electrically-evoked neuronal output by facilitating postsynaptic GABAAreceptors (GABAARs) and prolonging the action potential (AP) duration. Unexpectedly, Ang-II had no discernable effects on the electrical properties of SNc dopaminergic neurons. Also, and indicating a nonlinear relationship between electrical activity and neuronal output, following phasic photoactivation of SNr GABAergic neurons, Ang-II paradoxically enhanced the feedforward inhibitory input to SNc dopaminergic neurons. In sum, our observations describe an increasingly complex and heterogeneous response of the SN to Ang-II by revealing cell-specific responses and nonlinear effects on intranigral GABAergic neurotransmission. Our data further implicate the renin-angiotensin-system (RAS) as a functionally relevant neuromodulator in the substantia nigra, thus underscoring a need for additional inquiry.
Exposure to non-persistent pesticides and puberty timing: a systematic review of the epidemiological evidence
Authors: Castiello Francesca , Freire Carmen 
Published: March 2021

Background
Numerous modern non-persistent pesticides have demonstrated estrogenic/anti-androgenic activity and have been classified as endocrine-disrupting chemicals (EDCs). Processes involved in puberty development are vulnerable to EDCs, such as compounds that interfere with the metabolism or activity of sex steroids.

Objective
To conduct a systematic review of epidemiological studies on the relationship between early-life exposure to non-persistent pesticides and puberty timing and/or sexual maturation in girls and boys.

Methods
A systematic search was carried out using MEDLINE and SCOPUS databases, including original articles published up to November 2020.

Results
Thirteen studies were selected after excluding non-original and non-human studies. Exposure to different types of pesticides has been associated with altered puberty timing in girls and/or boys in eight studies. In utero exposure to atrazine has been related to earlier age of menarche in girls; exposure to organophosphate (OP) pesticides has been related to delayed sexual development in boys and girls; childhood pyrethroid exposure has been associated with pubertal delay in girls and pubertal advancement in boys; and prenatal/childhood exposure to multiple pesticides has been linked to earlier puberty onset in girls and pubertal delay in boys.

Conclusions
Most of the reviewed studies describe a relationship between pesticide exposure and changes in the age of puberty onset or sex hormone levels, although the quality of the evidence is generally low. Further well-designed longitudinal studies are warranted on specific classes of pesticides and on possible interactions between different types of compounds.
Selective vs non-selective alpha-blockade prior to adrenalectomy for pheochromocytoma: systematic review and meta-analysis
Authors: Zawadzka Karolina , Więckowski Krzysztof , Małczak Piotr , Wysocki Michał , Major Piotr , Pędziwiatr Michał , Pisarska-Adamczyk Magdalena 
Published: March 2021

Objective
Alpha-adrenergic blockade is currently the first choice of preoperative treatment in patients with functional pheochromocytoma and sympathetic paraganglioma. Nevertheless, there is no consensus whether selective or non-selective alpha-blockade is superior for preventing both perioperative hemodynamic instability and complications.

Design
Our study aimed to compare selective and non-selective alpha-blockade through a systematic review with meta-analysis.

Methods
MEDLINE, Embase, Web of Science and Cochrane Library were searched for eligible studies. Randomized and observational studies comparing selective and non-selective alpha-blockade in pheochromocytoma and sympathetic paraganglioma surgery in adults were included. Data on perioperative hemodynamic parameters and postoperative outcomes were extracted.

Results
Eleven studies with 1344 patients were enrolled. Patients receiving selective alpha-blockade had higher maximum intraoperative systolic blood pressure (WMD: 12.14 mmHg, 95% CI: 6.06–18.21, P < 0.0001) compared to those treated with non-selective alpha-blockade. Additionally, in the group pretreated with selective alpha-blockers, intraoperative vasodilators were used more frequently (OR: 2.46, 95% CI 1.44–4.20, P = 0.001). Patients treated with selective alpha-blockers had lower minimum intraoperative systolic blood pressure (WMD: −2.03 mmHg, 95% CI: −4.06 to −0.01, P = 0.05) and shorter length of hospital stay (WMD: −0.58 days, 95% CI: −1.12 to −0.04, P = 0.04). Operative time, overall morbidity and mortality did not differ between the groups.

Conclusions
This meta-analysis shows non-selective alpha-blockade was more effective in preventing intraoperative blood pressure fluctuations while maintaining comparable risk of both intraoperative and postoperative hypotension and overall morbidity.
Sodium-glucose co-transporter inhibitors in insulin-treated diabetes: a meta-analysis
Authors: Ferreira João Pedro , Oliveira Ana Cristina , Saraiva Francisca A , Vasques-Nóvoa Francisco , Leite-Moreira Adelino 
Published: March 2021

Background
Patients with insulin-treated type 2 diabetes (T2D) have a high risk of major adverse cardiovascular events. Sodium-glucose cotransporter inhibitors (SGLTi) improve outcomes without hypoglycaemic risk.

Aims
To study the effect of SGLTi in patients with T2D with and without background insulin treatment in outcome-driven RCTs.

Methods
Random effects models.

Results
A total of 54 374 patients with T2D were included in the analysis, of which 26 551 (48.8%) were treated with insulin. For 3P-MACE in patients without insulin treatment, the HR (95% CI) for the effect of SGLTi vs placebo was 0.93 (0.81–1.05), with moderate heterogeneity (I2 = 49.2%, Q statistic P = 0.11). In insulin-treated patients, the HR (95% CI) was 0.88 (0.82–0.95), without evidence of heterogeneity (I2 =0.0%, Q statistic P =0.91). The pooled effect evidenced a 10% reduction of 3P-MACE with SGLTi (HR: 0.90, 95% CI: 0.85–0.96), without SGLTi-by-insulin interaction P = 0.53. For the composite outcome of HF hospitalisation or cardiovascular death in patients without insulin treatment, the HR (95% CI) for the effect of SGLTi vs placebo was 0.77 (0.61-0.92), with marked heterogeneity (I2 = 66.8%, Q statistic P = 0.02). In insulin-treated patients, the HR (95% CI) was 0.77 (0.68–0.86), without significant heterogeneity (I2 = 31.7%, Q statistic P = 0.25). The pooled effect evidenced a 23% reduction of HF hospitalisations or cardiovascular death with SGLTi (HR: 0.77, 95% CI: 0.68–0.85), without SGLTi-by-insulin interaction P = 0.98.

Conclusion
SGLTi reduces cardiovascular events regardless of insulin use. However, the treatment effect is more homogeneous among insulin-treated patients, supporting the use of SGLTi for the treatment of patients with T2D requiring insulin for glycaemic control.
Effect of salt and temperature on the growth of Escherichia coli PSII
Authors: Medvedova A. , Kocis-Koval M. , Valik L. 
Published: March 2021

AbstractPresence of pathogenic strains of Escherichia coli in foodstuffs may pose a health risk for a consumer. Therefore, knowledge on the effect of environmental factors on the growth ability of E. coli is of great importance. In this work, the effect of incubation temperature (6–46 °C) and the combined effect of temperature and water activity (0.991–0.930) on the growth dynamic of E. coli PSII were analysed. Based on the growth curves obtained, growth parameters were calculated by using the Baranyi D-model. Growth parameters were further analysed in secondary phase of predictive modelling. Using the CM model that describes the effect of combined factors, cardinal values (Tmin = 4.8 ± 0.4 °C, Topt = 41.1 ± 0.8 °C, Tmax = 48.3 ± 0.9 °C, awmin = 0.932 ± 0.001, and awopt = 0.997 ± 0.003) for the isolate were calculated. Under optimal conditions, the specific growth rate is µopt = 2.84 ± 0.08 h−1. The results obtained may contribute to the assessment of the risk associated with the possible E. coli presence in raw materials and to the search for preventive measures with defined degree of accuracy and reliability.
Airway obstruction can be better predicted using Global Lung Function Initiative spirometry reference equations in Marfan syndrome
Authors: Kolonics-Farkas A. M. , Kovats Z. , Bohacs A. , Odler B. , Benke K. , Agg B. , Szabolcs Z. , Müller V. 
Published: March 2021

AbstractMarfan syndrome is a genetic disorder of the connective tissue, including involvement of the lungs.Pulmonary function test was performed in 32 asymptomatic adult Marfan patients using European Community for Coal and Steel (ECCS) and Global Lung Function Initiative (GLI) reference values.Using GLI equations for reference, significantly lower lung function values were noted for forced vital capacity (FVC) (87.0 ± 16.6% vs. 97.1 ± 16.9%; P < 0.01) and forced expiratory volume in the first second (FEV1) (79.6 ± 18.9% vs. 88.0 ± 19.1%; P < 0.01) predicted compared to ECCS. Obstructive ventilatory pattern was present in 25% of the cases when calculating with GLI lower limit of normal (LLN), and it was significantly more common in men as compared to women (n = 6, 50% vs. n = 2, 10%; P = 0.03).GLI is more suitable to detect early ventilatory changes including airway obstruction in young patients with special anatomic features, and should be used as a standard way of evaluation in asymptomatic Marfan population.
Incidence and clinical predictors of infections in patients treated with severe systemic ANCA-associated vasculitis
Authors: Haris Á. , Polner K. , Arányi J. , Braunitzer H. , Kaszás I. 
Published: March 2021

AbstractBackgroundImmunosuppressive therapy has improved the outcome of ANCA-associated vasculitis (AAV), but infectious morbidity and mortality remained high. Recognizing its risk factors seems crucial for prevention, aiming to increase survival of these patients.MethodsWe investigated the incidence and types of infections and assessed predictive factors in 132 patients with severe systemic AAV.ResultsPatients with lower than median incidence of total infections/patient-year during induction had lower baseline serum creatinine, dialysis requirement and Charlson comorbidity index (CCI), compared to those with higher than median incidence (P = 0.037; P = 0.024; P = 0.001; respectively). In subgroups with below and above than median number of severe infections/patient-year during induction, differences were found in baseline creatinine (P = 0.002) and dialysis requirement (P = 0.001); comparing the same cohorts during maintenance immunosuppression, baseline dialysis requirement, diabetes, CCI, and dose of cyclophosphamide (CYC) administered as induction therapy differed significantly (P = 0.019; P = 0.015; P = 0.001; P = 0.015, respectively). Severe infections were predicted by baseline serum creatinine (OR 1.002 [CI 1.001–1.003]) and pulmonary manifestation (OR 2.153 [CI 1.017–4.560]) during induction immunosuppression. In multivariable Cox regression model all-cause mortality was independently predicted by severe infection (HR 1.998 [CI 1.214–3.287]). Among the 168 positive cultures Gram-negative bacteria were responsible for blood stream infections in 33%, and respiratory tract infections in 72%.ConclusionsAdvanced renal failure, pulmonary involvement and high degree of comorbidities increase the risk of infection in AAV. Those who suffer infection during induction immunosuppression have worse long-term survival. Our findings indicate the need for high vigilance for infections and close follow-up of comorbidities when treating AAV.
Building thermal capacity for peak shifting, based on PV surplus production
Authors: Ervin Haber Istvan , Bencsik Gergely , Naili Basma , Szabo Istvan 
Published: March 2021

AbstractEnergy storage on grid level is still a critical issue. Inventions related to development and control of smart buildings, including integrated solar systems can be easily realized by smart control of building management including storage. At buildings, which have high heat capacitance the part of the stored heat can be used for grid stabilization. This means the grid can be balanced with well-set up heating/cooling strategy and well-scheduled timetable via intelligent control of buildings. A possible solution is introduced in this paper, where the surplus production is used for overcooling the building, while the building thermodynamic properties are making it possible to store this amount of energy for days. This paper analyses a cost-effective solution of grid energy storage through a case study.
Facial bones segmentation from skull point clouds based on deviation angle
Authors: Ulinuha Masy Ari , Yuniarno Eko Mulyanto , Purnama I. Ketut Eddy , Hariadi Mochamad 
Published: March 2021

AbstractFacial bones segmentation is an important step to understanding a skull. In this paper, a method for segmenting facial bones from skull point clouds is proposed. The segmentation is based on the deviation angle features. The method consists of three phases: surface normal estimation, feature extraction, and point clouds classification. The method is applied to skull point clouds derived from computed tomography images. For evaluation, the method is compared with manual segmentation. The method has succeeded in segmenting facial bones with Precision = 0.836, Recall = 0.951, and F = 0.890.