bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropathological correlates of vulnerability and resilience in the cerebellum in Alzheimer's disease
Authors: Samstag Colby L. , Chapman Nicola H. , Gibbons Laura E. , Geller Julianne , Loeb Nicholas , Dharap Siddhant , Yagi Mayumi , Cook David G. , Pagulayan Kathleen F. , Crane Paul K. , Larson Eric B. , Wijsman Ellen M. , Latimer Caitlin S. , Bird Thomas D. , Keene C. Dirk , Carlson Erik S. 
Published: December 2024

AbstractINTRODUCTIONWe investigated whether the cerebellum develops neuropathology that correlates with well‐accepted Alzheimer's disease (AD) neuropathological markers and cognitive status.METHODSWe studied cerebellar cytoarchitecture in a cohort (N = 30) of brain donors. In a larger cohort (N = 605), we queried whether the weight of the contents of the posterior fossa (PF), which contains primarily cerebellum, correlated with dementia status.RESULTSAlthough there was no granular layer (GL) cell loss, GL area was lower in AD cases, particularly in the lateral cerebellum. Lower numbers of mossy fiber synaptic terminals in the cerebellar GL of AD cases correlated with Braak stages IV–VI. PF content weight correlated with dementia independently of age, neuropathology, and education. In addition, we found that a measure of the relative size of the PF content weight to total brain weight correlated with less dementia.DISCUSSIONThese results confirm that the cerebellum is not spared neuropathological damage in AD.Highlights
Novel evidence of cerebellar atrophy in the granule cell layer of the lateral cerebellar cortex (or ‘cognitive cerebellum’), and loss of a specific cerebellar synapse type in this region, the cerebellar glomerulus. Both correlated with dementia status and Braak stages IV through VI, in a cohort with complete neuropathological characterization. Although there have been recent brain imaging studies suggesting a role for cerebellum in Alzheimer's disease, we believe our study constitutes some of the most concrete neuropathological evidence to date of anatomic and synaptic substrates that are disrupted in AD. These changes in this cerebellar region may even play a role in the etiology of cognitive symptoms.
Novel evidence that individuals with lower postmortem cerebellar weights showed more cognitive decline, independent of classical neuropathology markers such as Braak stage, Thal phase, or Corsortium to Establish a Registry for Alzheimer's Disease (CERAD) score, suggesting a role for this brain region in dementia, using advanced statistical analysis of a large unbiased population cohort (n = 605), the Adult Changes in Thought (ACT) study.
Conversely, a measure of how intact the cerebellum was correlated with less dementia, independent of classical neuropathology markers and cerebral cortical weight, again, in the ACT cohort of 605 brain donors. We believe that this novel finding has relevance and implications for the identification of resilience factors, which may protect against the development of dementia.
Integrating rare pathogenic variant prioritization with gene‐based association analysis to identify novel genes and relevant multimodal traits for Alzheimer's disease
Authors: Cao Jixin , Zhang Cheng , Lo Chun‐Yi Zac , Guo Qihao , Ding Jing , Luo Xiaohui , Zhang Zi‐Chao , Chen Feng ,   the ZIB Consortium, Cheng Tian‐Lin , Chen Jingqi , Zhao Xing‐Ming ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: December 2024

AbstractINTRODUCTIONIncreasing evidence has highlighted rare variants in Alzheimer's disease (AD). However, insufficient sample sizes, especially in underrepresented ethnic groups, hinder their investigation. Additionally, their impact on endophenotypes remains largely unexplored.METHODSWe prioritized rare likely‐deleterious variants based on whole‐genome sequencing data from a Chinese AD cohort (n = 988). Gene‐based optimal sequence kernel association tests were conducted between AD cases and normal controls to identify AD‐related genes. Network clustering, endophenotype association, and cellular experiments were conducted to evaluate their functional consequences.RESULTSWe identified 11 novel AD candidate genes, which captured AD‐related pathways and enhanced AD risk prediction performance. Key genes (RABEP1, VIPR1, RPL3L, and CABIN1) were linked to cognitive decline and brain atrophy. Experiments showed RABEP1 p.R845W inducing endocytosis dysregulation and exacerbating toxic amyloid β accumulation, underscoring its therapeutic potential.DISCUSSIONOur findings highlighted the contributions of rare variants to AD and provided novel insights into AD therapeutics.Highlights
Identified 11 novel AD candidate genes in a Chinese AD cohort.
Correlated candidate genes with AD‐related cognitive and brain imaging traits.
Indicated RABEP1 p.R845W as a critical AD contributor in the endocytic pathway.
Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta‐analysis
Authors: Khalafi Mohammad , Dartora William J. , McIntire Laura Beth J. , Butler Tracy A. , Wartchow Krista M. , Hojjati Seyed Hani , Razlighi Qolamreza R. , Shirbandi Kiarash , Zhou Liangdong , Chen Kewei , Xi Ke , Banerjee Samprit , Foldi Nancy , Pahlajani Silky , Glodzik Lidia , Li Yi , de Leon Mony J. , Chiang Gloria C. 
Published: December 2024

AbstractOur review summarizes the diagnostic accuracy of plasma and cerebrospinal fluid (CSF) phosphorylated tau 217 (p‐tau217) in detecting amyloid and tau pathology on positron emission tomography (PET). We systematically reviewed studies that reported the diagnostic accuracy of plasma and CSF p‐tau217, searching MEDLINE/PubMed, Scopus, and Web of Science through August 2024. The accuracy of p‐tau217 in predicting amyloid and tau pathology on PET was evaluated in 30 studies. Both plasma and CSF p‐tau217 effectively detect amyloid and tau PET deposition. Plasma p‐tau217 showed 82% sensitivity for detecting amyloid and 83% for tau, with 86% and 83% specificity, respectively. CSF p‐tau217 had 79% sensitivity for amyloid and 91% for tau, with 91% and 84% specificity. p‐tau217 effectively identifies Alzheimer's disease (AD) pathology. Plasma p‐tau217 was comparable to CSF p‐tau217 in detecting amyloid deposition on PET. Despite being less sensitive for detecting tau deposition on PET, plasma p‐tau217 can be an efficient screening tool for underlying AD pathology.Highlights
Plasma phosphorylated tau 217 (p‐tau217) serves as a viable biomarker alternative to cerebrospinal fluid p‐tau217 due to the strong concordance between their results.
Plasma p‐tau217 accurately identifies amyloid and tau positron emission tomography (PET) positivity, exhibiting a low rate of false negatives and positives, thereby establishing it as a reliable diagnostic tool for Alzheimer's disease (AD).
Plasma p‐tau217 demonstrates slightly higher accuracy in predicting amyloid PET positivity compared to tau PET positivity.
Plasma p‐tau217 demonstrates higher predictive accuracy in detecting AD pathology among cognitively impaired individuals, compared to cognitively unimpaired individuals, suggesting its enhanced utility as a diagnostic biomarker in clinical settings.
Premenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life
Authors: Kantarci Kejal , Kapoor Ekta , Geske Jennifer R. , Castillo Anna , Fields Julie A. , Kara Firat , Knyazhanskaya Evdokiya E. , Schwarz Christopher G. , Senjem Matthew L. , Bailey Kent R. , Lowe Val , LeBrasseur Nathan K. , Rocca Walter A. , Mielke Michelle M. 
Published: December 2024

AbstractINTRODUCTIONPremenopausal bilateral oophorectomy (PBO) before the age of 46 years is associated with an increased risk of dementia. We investigated the long‐term effects of PBO performed before age 50 years on amyloid beta (Aβ), tau, and neurodegeneration imaging biomarkers of Alzheimer's disease (AD).METHODSMayo Clinic Cohort Study of Oophorectomy and Aging‐2 participants were divided into early PBO (< 46 years; n = 61), and late PBO (46–49 years; n = 51) groups and were compared to referent women who did not undergo PBO (n = 119).RESULTSEarly PBO was associated with thinner entorhinal cortex (p = 0.014), higher tau load at higher levels of Aβ load (Pp = 0.005), higher Aβ load (p = 0.026), and smaller temporal lobe cortical thickness (p = 0.022), only at older ages compared to the referent group.DISCUSSIONPBO before the age of 46 years is associated with entorhinal cortex thinning, elevated tau at higher Aβ levels, along with an AD‐like pattern of atrophy at older ages.CLINICAL TRIALS REGISTRATIONNCT03821857 sex‐specific effects of endocrine disruption on aging and AD.Highlights
Premenopausal bilateral oophorectomy (PBO) before the ages of 46 (early PBO) years and ages 46 to 49 (late PBO) years was studied.
Early PBO was associated with reduced entorhinal cortex thickness later in life.
Early PBO was associated with greater amyloid beta (Aβ) load at older ages.
Early PBO was associated with greater Alzheimer's disease pattern of atrophy at older ages.
Early PBO was associated with higher tau load at higher Aβ levels.
Efficient Direct Air Capture in Industrial Cooling Towers Mediated by Electrochemical CO2 Release
Authors: Zheng Ao‐Chuan , Zou Ye‐Bin , Du Lin , Zhang Qiang , Daasbjerg Kim , Hu Xin‐Ming 
Published: December 2024

AbstractDirect air capture (DAC) is a promising technology for mitigating global climate change but suffers from low efficiency, small scale, and high cost due to the dilute atmospheric CO2, limited size of air contactors, and heat‐driven CO2 release. Here, we propose combining DAC with widely used industrial cooling towers to extract CO2 from the air and using electrolysis to release the captured CO2 at room temperature. We first prepare a buffered absorbent solution consisting of sodium glycinate, glycine, and sodium chloride for effective CO2 capture from the air, solving the incompatibility problem of the cooling towers with conventional absorbents. Next, we employ a three‐chamber electrolyzer for efficient release (≥95 %) of the captured CO2 with high purity (≥98 %) by constant current electrolysis at room temperature, bypassing the conventional energy‐intensive heating process. The entire DAC system can operate stably for multiple cycles, and the mechanism for consecutive CO2 capture and release is uncovered. This work reveals the great potential of running DAC in industrial cooling towers coupled with electrochemically‐driven CO2 release, opening up new avenues for curbing the increasingly severe climate change.
A Universal Design of Lithium Anode via Dynamic Stability Strategy for Practical All‐Solid‐State Batteries
Authors: Deng Tao , Wang Changhong , Wan Hongli , Li Ai‐Min , He Xinzi , Wang Zeyi , Cao Longsheng , Fan Xiulin , Wang Chunsheng 
Published: December 2024

AbstractAll‐solid‐state Li‐metal battery (ASSLB) chemistry with thin solid‐state electrolyte (SSE) membranes features high energy density and intrinsic safety but suffers from severe dendrite formation and poor interface contact during cycling, which hampers the practical application of rechargeable ASSLB. Here, we propose a universal design of thin Li‐metal anode (LMA) via a dynamic stability strategy to address these issues. The ultra‐thin LMA (20 μm) is in situ constructed with uniform highly Li‐ion conductive solid‐electrolyte interphase and composite‐polymer interphase (CPI) via electroplating process. As a result, the passivation layer with poor Li‐ion conduction on Li anode can be dissolved and small surface resistance can be achieved due to the good compatibility of CPI to SSEs. The cycling of Li symmetric cell with Li6PS5Cl thin film electrolyte (<100 μm) shows a high critical current density of >2.0 mA cm−2 with excellent cycling stability at 1.0 mA cm−2. The ASSLBs paring with Ni‐rich LiNi0.6Mn0.2Co0.2O2 cathode demonstrated the feasibility of engineered LMA design by presenting good rate capability from 0.1 C to 1.0 C at room temperature, as well as long‐term cycling stability (81 % retention after 100 cycles). This work represents a general pathway to make thin dendrite‐free LMA available for high‐energy‐density ASSLBs.
Sugar Auxiliary Group Assisted Diversity‐Oriented Enzymatic Modular Synthesis of 0‐Series Ganglioside Glycans
Authors: Ye Jinfeng , Zhong Kan , Hu Zhi‐Fei , Liu Chang‐Cheng , Li Ming , Wu Peng , Cao Hongzhi 
Published: December 2024

AbstractOwing to the inaccessibility of β1–4‐N‐acetylgalactosaminyltransferase for direct glycan chain elongation, the enzymatic synthesis of 0‐series gangliosides with extended backbones has not been explored. In this study, sialic acid was enzymatically introduced as an auxiliary group to overcome the limitation of substrate specificity of Campylobacter jejuni β1–4‐N‐acetylgalactosaminyltransferase (CjCgtA) to achieve the synthesis of desired extended 0‐series ganglioside core structures, and the sialic acid auxiliary group could be removed by sialidase at appropriate stages. A bacterial α2–6‐sialyltransferase from Photobacterium damselae (Pd2,6ST) exhibited unexpected acceptor substrate specificity for 0‐series ganglioside core structures, providing ready access to complex gangliosides bearing the sialyl N‐acetylgalactosamine unit. The 0‐series ganglioside core structures as the key acceptor substrates were further diversified by sequential enzymatic modular assembly to generate a collection of 31 complex 0‐series ganglioside glycans after removal of the sugar auxiliary group of sialic acid at the appropriate stage.
Liquid Crystalline Nanorods by Synchronized Polymerization, Self‐Assembly and Oriented Attachment for Utilization in Magnetically Responsive Displays
Authors: Wang Xiao , Lu Jiawei , Shi An‐Chang , Liu Bing 
Published: December 2024

AbstractThe creation of anisotropic nanoparticles (NPs) by polymerization and/or self‐assembly (SA) has significantly promoted the applications of polymer nanomaterials in many fields. However, polymer nanorods are not easily accessible via conventional polymerization or SA. Here we report a one‐step route to synthesize single‐domain smectic liquid crystalline (LC) nanorods utilizing oriented attachment (OA) that was usually found in the synthesis of inorganic NPs, synchronized with polymerization and SA. The synchronization was achieved by developing a novel stabilizer derived from a thermo‐responsive polyelectrolyte system. Mechanistic studies reveal that controlling the thermo‐responsive behavior and the distribution of stabilizers on NPs enabled OA. The LC nanorods can further form hierarchical colloidal LCs, which show much larger light transmittance than that of non‐LC nanorods. Moreover, we demonstrate that this LC system can be manipulated by an external magnetic field, thus providing a candidate material for magnetic‐responsive display.
Self‐Healing 2D Anion‐Organic Frameworks for Low‐Temperature Water Release
Authors: Li Zhong‐Qiu , Shao Jiang‐Yang , Gong Zhong‐Liang , Liang Tongling , Hao Xiang , Yao Jiannian , Zhong Yu‐Wu 
Published: December 2024

AbstractMolecular frameworks have recently shown a great potential in atmospheric water harvesting, in which the water release at low temperatures is challenging. Anion‐organic frameworks based on anion‐coordination chemistry are presented herein to meet this challenge. These frameworks are prepared as tubular single crystals in pure water from the in situ protonation and crystallization of pyridine‐terminated triphenylamine derivatives with hydrochloric or hydrobromic acid. They possess a 2D honeycombed porous structure and carry halogen anions confined within 1D hexagonal nanochannels with a modular size of 1.7–2.3 nm. They exhibit a high water uptake of up to 0.87 g g−1 and a water release onset temperature as low as −90 °C. The water uptake and release induce significant changes in the crystal morphology and absorption and emission properties of these framework crystals, providing a visual indication of their hydration states over a wide temperature range. The kinetics of dehydration at subglacial temperatures is successfully determined by emission spectral shifts. These framework crystals show a high water‐stability and can be used for repeated water capture and release thanks to a rapid and robust self‐healing capability. This discovery opens opportunities for the design and synthesis of flexible and self‐healing frameworks for porosity‐related applications.
Access to Polyhydroxyalkanoates with Diverse Syndiotacticity via Polymerization by Spiro‐Salen Complexes and Insights into the Stereocontrol Mechanism
Authors: Huang Hao‐Yi , Ren Bai‐Hao , Xie Min , Huang Yu‐Ting , Li Kun , Cai Zhongzheng , Lu Xiao‐Bing , Zhu Jian‐Bo 
Published: December 2024

AbstractPolyhydroxyalkanoates (PHAs) have attracted broad interest as promising sustainable materials to address plastic pollution and resource scarcity. However, the chemical synthesis of stereoregular PHAs via ring‐opening polymerization (ROP) has long been an elusive endeavor. In this contribution, we exploited a robust spiro‐salen yttrium complex (Y3) as the catalyst to successfully prepare syndiotactic PHAs with diverse pendent groups. Simply altering the ratio of enantiomeric catalysts allowed to access of PHAs with diverse syndiotacticity (Pr=0.5–0.99, from sticky oil to tough materials), delivering tunable thermal properties (glass transition temperature, Tg from −52 to 70 °C and melting transition temperature, Tm from 38 to 223 °C). A combined experimental and computational study suggested a polymeric exchange mechanism could boost the polymerization activity and control the syndioselectivity.
Promoting Photocatalytic Hydrogen Evolution by Stabilization of Excited Triplet States and Enhancement of Internal Electric Field at Dye/PCN Interface
Authors: Chen Yanting , Jiang Changzun , Liu Siwei , Yuan Wentao , Li Qianqian , Li Zhen 
Published: December 2024

AbstractThe heterojunction photocatalysts composed of organic dyes and polymeric carbon nitride (PCN) have great potential for photocatalytic hydrogen evolution (PHE). However, serious charge recombination exists at the dye/PCN interface for the large gaps in time scales and the poor driving force of charge transfer process. Herein, both the excited triplet states of organic dyes with long lifetimes and strong internal electric fields (IEF) as charge transfer driving forces are achieved by the construction of high dipole moments with aromatic‐core engineering, and modulation of dye aggregates by alkyl modification. Accordingly, PHE efficiency can achieve up to 833.49 μmol/h, over 36‐fold that of PCN/Pt (23.34 μmol/h) under the same conditions. The relationship between molecular structures and PHE performance has been systematically investigated by the photophysical properties of organic dyes and the strength of IEF at dye/PCN interface. It afforded an efficient strategy to balance the charge transfer process in PHE systems, which can guide the molecular design of organic dyes with optimized aggregated behaviors and stable excited triplet states.
Achieving Photocatalytic Overall Nitrogen Fixation via an Enzymatic Pathway on a Distorted CoP4 Configuration
Authors: Wang Xin , Zhao Yuqi , Wu Xi , Zhang Bin , Tian Jian , Wong Wai‐Yeung , Zhang Fuxiang 
Published: December 2024

AbstractPhotocatalytic nitrogen (N2) fixation over semiconductors has always suffered from poor conversion efficiency owing to weak N2 adsorption and the difficulty of N≡N triple bond dissociation. Herein, a Co single‐atom catalyst (SAC) model with a C‐defect‐evoked CoP4 distorted configuration was fabricated using a selective phosphidation strategy, wherein P‐doping and C defects co‐regulate the local electronic structure of Co sites. Comprehensive experiments and theoretical calculations revealed that the distorted CoP4 configuration caused a strong charge redistribution between the Co atoms and adjacent C atoms, minimizing their electronegativity difference. Consequently, the N2 adsorption pattern switched from an “end‐on” to a “side‐on” mode with a high N2 adsorption energy of −1.40 eV and an elongated N−N bond length of 1.20 Å, notably decreasing the N2 adsorption/activation energy barrier. In the absence of sacrificial agents, the Co SAC achieved excellent photocatalytic overall N2 fixation performance via an enzymatic pathway. The NH3 yielding rate peaked at 1249.5 μmol h−1 g−1 with an apparent quantum yield of 3.51 % at 365 nm. Moreover, the selective phosphidation strategy has universality for synthesizing other SACs, such as those containing Ni and Fe. This study offers new insight into co‐regulating the electronic structure of SACs for efficient photocatalytic overall N2 fixation.
Breaking the Stability‐Activity Trade‐off of Oxygen Electrocatalyst by Gallium Bilateral‐Regulation for High‐Performance Zinc‐Air Batteries
Authors: Li Yunrui , Xu Jiaqi , Lan Fan , Wang Yao , Jiang Hairong , Wu Xueke , Huang Ya , Li Run , Jiang Qinyuan , Gao Di , Zhu Ping , Zhao Siming , Zhao Yanlong , Wang Fei , Zhang Libo , Zhang Longgui , Zhang Rufan 
Published: December 2024

AbstractThe rational design of metal oxide catalysts with enhanced oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) performance is crucial for the practical application of aqueous rechargeable zinc‐air batteries (a‐r‐ZABs). Precisely regulating the electronic environment of metal‐oxygen (M−O) active species is critical yet challenging for improving their activity and stability toward OER and ORR. Herein, we propose an atomic‐level bilateral regulation strategy by introducing atomically dispersed Ga for continuously tuning the electronic environment of Ru−O and Mn−O in the Ga/MnRuO2 catalyst. The Ga/MnRuO2 catalyst breaks the stability‐activity restriction, showing remarkable bifunctional performance with a low potential gap (ΔE) of 0.605 V and super durability with negligible performance degradation (300,000 ORR cycles or 30,000 OER cycles). The theoretical calculations revealed that the strong coupling electron interactions between Ga and Ru−O/Mn−O tuned the valence state distribution of the metal center, effectively modulating the adsorption behavior of *O/*OH, thus optimizing the reaction pathways and reducing the reaction barriers. The a‐r‐ZABs based on Ga/MnRuO2 catalysts exhibited excellent performance with a wide working temperature range of −20–60 °C and a long lifetime of 2308 hours (i.e., 13,848 cycles) under a current density of 5 mA cm−2 at −20 °C.
A Three‐Tiered Golf Anode towards Ultralong‐Life Zn−Mn Aqueous Batteries
Authors: Hu Qiang , Wang Xinrui , Cui Jiuzhi , Hou Jiabing , Liu Xingquan , Yang Jia‐Lin , Gu Zhen‐Yi , Zhao Jingxin , Xu Bingang , Wu Xing‐Long 
Published: December 2024

AbstractZn−Mn aqueous batteries (ZMABs) are widely recognized as a promising candidate for large‐scale energy storage due to their cost‐effectiveness, high safety and environmental friendliness. However, the practical application of ZMABs is hindered by inherent electrical contact loss, hydrogen evolution and dendrite growth on traditional anodes. Here, a three‐tiered golf anode with high conductivity is developed to simultaneously enhance the reversibility of Zn and Mn metals. The three‐tiered golf anode is achieved by inner zinc powder, intermediate carbon and outer bismuth layer, which can effectively enhance the Gibbs free energy and mitigate the volume change of the anode, thus enabling stable Zn−Mn cycling. As a proof of concept, Zn−Mn full cells (coupled to CNT@MnO2) achieve an ultralong cycle life with 94.6 % capacity retention at 2 A g−1 after 16,000 cycles. This study presents valuable insights into the structural design of anodes aimed at enhancing the stability and durability of ZMABs.