bluuebunny/crossref_metadata_2025_split huggingface dataset:
РОЛЬ ПОЛІМОРФІЗМУ ГЕНІВ ЛЕПТИНУ ТА РЕЦЕПТОРА ДО ЛЕПТИНУ У РЕАЛІЗАЦІЇ МЕТАБОЛІЧНИХ ЕФЕКТІВ ОМЕГА-3 ПОЛІНЕНАСИЧЕНИХ ЖИРНИХ КИСЛОТ У ХВОРИХ НА ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ СХІДНОУКРАЇНСЬКОЇ ПОПУЛЯЦІЇ
Authors: Красова Наталія , Караченцев Юрій , Горшунська Мар'яна , Колеснікова Алла , Лещенко Жанна , Гладких Олександр , Воропай Тетяна , Романова Ірина , Полторак Вікторія 
Published: December 2021

Відомо, що однонуклеотидні поліморфізми (ОНП) в генах адипокінів здатні впливати як на розвиток патологічних станів, пов’язаних з ожирінням, так і на ефективність застосованої фармакотерапії. Мета. Оцінити вплив поліморфних варіантів генів лептину LEP 2548G>A (rs7799039) та рецептора до лептину LEPR 223G>А (rs1137101) на терапевтичну ефективність омега-3 поліненасичених жирних кислот у хворих на цукровий діабет 2 типу східноукраїнської популяції. Матеріали та методи. 61 хворий на цукровий діабет (ЦД) 2 типу (ч/ж: 34/27, вік 53,4±1,4 років, тривалість захворювання 5,3±0,7 років, глікемія 9,1±0,4 ммоль/л; HbА1c 7,7±0,2%) з надлишковою масою тіла або ожирінням (індекс маси тіла 33,3±0,9 кг/м2) отримував додатково до стандартної пероральної цукрознижуючої терапії (сульфонілсечовина та/або метформін) щоденно протягом 3 місяців препарат омега-3 поліненасичених жирних кислот (ПНЖК) (460 мг ейкозапентаєнової кислоти + 380 мг докозагексаєнової кислоти). Контрольну групу складав 21 суб’єкт. Клініко-біохімічні параметри оцінювали до та після курсу лікування. Генотипування за ОНП LEP 2548G>A та LEPR 223G>А проводили за допомогою методу полімеразної ланцюгової реакції з використанням відповідних праймерів та ендонуклеаз (HhaI і MspI). Результати. Визначено, що хворі на ЦД 2 типу носії домінантного алеля G за ОНП 2548G>A гена лептину демонструють більшу ефективність омега-3 ПНЖК відносно зниження загальної інсулінорезистентності та інсулінорезистентності жирової тканини. Виявлено асоціацію рецесивного генотипу (АА) за поліморфізмом 223G>А гена рецептора лептину з більшою ефективністю омега-3 ПНЖК відносно зменшення інсулінорезистентності жирової тканини. Вивчені поліморфізми генів адипокінової ланки мають вплив на реалізацію терапевтичної гормонально-метаболічної ефективності препарату омега-3 ПНЖК за умов 3-місячного введення у пацієнтів з ЦД 2 типу та надлишковою масою тіла/ожирінням східноукраїнської популяції. Дані щодо поліморфного варіанту гена LEP та/або LEPR можуть бути використані в межах фармакогенетики як підґрунтя для персоналізованої профілактики та терапії з прогнозованим ефектом фармакологічного втручання.
Kerentanan Perempuan dalam Surveillance Capitalism
Authors: Lejo Bergita P. Pricelia 
Published: December 2021

Tulisan ini bertujuan untuk menganalisa kerentanan perempuan terhadap Kekerasan Gender Berbasis Online (KGBO) di dalam ruang digital. Studi ini menggunakan konsep kapitalisme pengawasan/surveillance capitalism dan symbolic violence sebagai dasar untuk memahami logika ekonomi dan juga kekerasan yang berlangsung dalam ruang digital. Ruang digital sebagai alat ekonomi tidak hanya menghasilkan “behavioral surplus” sebagai material baru tetapi juga menjadi ruang bagi terbentuknya “dominant habitus” tentang siapa itu perempuan dan bagaimana seharusnya perempuan merepresentasikan dirinya. Dominant habitus yang senantiasa direproduksi mampu menciptakan kebutuhan ekonomi bagi perempuan melalui komodifikasi dan bahkan eksploitasi terhadap tubuh perempuan yang terepresentasi dalam teks gambar, dan video di dalam platform digital. Melalui proses-proses ini, perempuan mengalami kekerasan simbolik yang terus-menerus direproduksi dalam dominant habitus. Dengan demikian, bekerjanya surveillance capitalism dan menguatnya dominant habitus di dalamnya menjadi kondisi yang membuka ruang bagi berlangsungya KGBO terhadap perempuan. Dengan menggunakan perspektif kritis dalam memandang KGBO tulisan ini hendak mendalami proses-proses yang mengkondisikan kerentanan perempuan di dalam ranah digital. Pemahaman akan hal-hal tersebut menjadi basis penting untuk memikirkan secara tepat posisi perempuan di dalam ruang digital yang saat ini secara luas diterima sebagai condition sine qua non yang di dalamnya berbagai bentuk relasi berlangsung. Dengan demikian, tulisan ini memberikan pijakan dasar untuk mendorong dan merumuskan beberapa agenda perubahan.
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This paper aims to analyze women's vulnerability to Online-Based Gender Violence (KGBO) in the digital platform. This study uses the concept of surveillance capitalism and symbolic violence as a basis for understanding the economic logic and violence that takes place in today's digital platform. Digital platform as an economic tool not only produces a "behavioral surplus" as a new material, but also becomes a space for the formation of a "dominant habitus"; who is women are and how women should represent themselves. Dominant habitus which is always reproduced is able to create economic needs for women through commodification and even exploitation of women's bodies which are represented in text, images and videos on digital platforms. Throughout these processes, mostly women suffer from symbolic violence which persistently reproduced by the dominant habitus. It obviously reflects the vulnerability of woman as the victim of KGBO. By using a critical perspective in looking at KGBO, this paper intends to explore the process that put women’s vulnerability in the digital arena. Understanding of these matters becomes an important basis for thinking about the exact position of women in the digital space which is currently widely accepted as a condition sine qua non in which various forms of relations take place. Thus, this paper provides a basic basis for encouraging and formulating several agendas for change.
Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD
Authors: Nowak Kristen L. , Farmer-Bailey Heather , Wang Wei , You Zhiying , Steele Cortney , Cadnapaphornchai Melissa A. , Klawitter Jelena , Patel Nayana , George Diana , Jovanovich Anna , Soranno Danielle E. , Gitomer Berenice , Chonchol Michel 
Published: December 2021

Background and objectives
Clinical manifestations of autosomal dominant polycystic kidney disease (ADPKD), including evidence of vascular dysfunction, can begin in childhood. Curcumin is a polyphenol found in turmeric that reduces vascular dysfunction in rodent models and humans without ADPKD. It also slows kidney cystic progression in a murine model of ADPKD. We hypothesized that oral curcumin therapy would reduce vascular endothelial dysfunction and arterial stiffness in children/young adults with ADPKD.

Design, setting, participants, & measurements
In a randomized, placebo-controlled, double-blind trial, 68 children/young adults 6–25 years of age with ADPKD and eGFR>80 ml/min per 1.73 m2 were randomized to either curcumin supplementation (25 mg/kg body weight per day) or placebo administered in powder form for 12 months. The coprimary outcomes were brachial artery flow-mediated dilation and aortic pulse-wave velocity. We also assessed change in circulating/urine biomarkers of oxidative stress/inflammation and kidney growth (height-adjusted total kidney volume) by magnetic resonance imaging. In a subgroup of participants ≥18 years, vascular oxidative stress was measured as the change in brachial artery flow-mediated dilation following an acute infusion of ascorbic acid.

Results
Enrolled participants were 18±5 (mean ± SD) years, 54% were girls, baseline brachial artery flow-mediated dilation was 9.3±4.1% change, and baseline aortic pulse-wave velocity was 512±94 cm/s. Fifty-seven participants completed the trial. Neither coprimary end point changed with curcumin (estimated change [95% confidence interval] for brachial artery flow-mediated dilation [percentage change]: curcumin: 1.14; 95% confidence interval, −0.84 to 3.13; placebo: 0.33; 95% confidence interval, −1.34 to 2.00; estimated difference for change: 0.81; 95% confidence interval, −1.21 to 2.84; P=0.48; aortic pulse-wave velocity [centimeters per second]: curcumin: 0.6; 95% confidence interval, −25.7 to 26.9; placebo: 6.5; 95% confidence interval, −20.4 to 33.5; estimated difference for change: −5.9; 95% confidence interval, −35.8 to 24.0; P=0.67; intent to treat). There was no curcumin-specific reduction in vascular oxidative stress or changes in mechanistic biomarkers. Height-adjusted total kidney volume also did not change as compared with placebo.

Conclusions
Curcumin supplementation does not improve vascular function or slow kidney growth in children/young adults with ADPKD.

Clinical Trial registry name and registration number
Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD, NCT02494141.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_02_07_CJN08950621.mp3
PHOSPHORYLATION OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II (CAMKII) AND EXTRACELLULAR REGULATED KINASE (ERK) IN STRIATUM MEDIATE NICOTINE DEPENDENCE IN BALB/C MICE
Authors: WILAR GOFARANA , FUKUNAGA KOHJI 
Published: December 2021

Objective: Nicotine is an active compound in tobacco and has a rewarding effect in the central nervous system (CNS), which may lead to dependence. Although nicotine dependence is elucidated by brain mechanisms, synaptic molecular substrates underlying the dependence remain unclear. We hypothesized that reward signaling is mediated by dopamine and glutamate receptors, in where calcium/calmodulin-dependent kinase II (CaMKII) and extracellular signal-regulated kinase (ERK) may mediate the synaptic signaling of dependence.
Methods: To investigate the roles of both CaMKII and ERK on nicotine dependence were assessed by conditioned place preference (CPP) methods followed by dissection. One day after conditioning, preference scores were measured to evaluate nicotine dependence. Mice were sacrificed and their striatum were dissected out for immunoblotting analyses of CaMKII and ERK phosphorylation.
Results: Nicotine-induced conditioned place preference as a symptom of nicotine dependence. CaMKII and ERK phosphorylation in striatum significantly increased along with the development of nicotine dependence.
Conclusion: We should next apply pharmacological strategies to manipulate CaMKII and ERK signaling. In particular, disruption of reconsolidation by disrupting CaMKII and ERK signaling may propose an attractive therapeutic approach to inhibit nicotine dependence.
DECOCTION OF POMEGRANATE (PUNICA GRANATUM L.) PEEL AS AN ANTHELMINTIC AGAINST TAENIA SAGINATA
Authors: SAPTARINI NYI MEKAR , MUSTARICHIE RESMI 
Published: December 2021

Objective: The purpose of this study was to investigate the anthelmintic activity of pomegranate (Punica granatum L.) peel decoction against Taenia saginata.
Methods: The in vitro assay was conducted by observing the motility of T. saginata, which is isolated from cattle’s gastrointestinal tract, in various concentrations of pomegranate peel decoction with albendazole as a positive control.
Results: The results showed that the anthelmintic activity was dependent on decoction concentration and the duration of contact between decoction and nematode. Decoction at moderate concentration causes paralysis, while high concentration causes death. The 75% and 100% pomegranate peel decoction started to cause death at 240 min and 150 min after contact with T. saginata.
Conclusion: It was concluded that pomegranate peel decoction has anthelmintic activity.
FORMULATION AND EVALUATION OF PEEL OFF GEL FACIAL MASK FROM ARABICA COFFEE FRUIT PEEL EXTRACT (COFFEA ARABICA L.)
Authors: TANJUNG YENNI PUSPITA , JULIANTI ANDI IKA , ISNAYANTI IRNI , R. AGUSTIN 
Published: December 2021

Objective: The aim of this study was to obtain a peel off gel facial mask preparation from Arabica coffee fruit peel extract that meets the requirements and to determine the antioxidant activity of Arabica coffee fruit peel extract and peel off gel facial mask preparation from coffee fruit peel extract
Methods: In this study, three formulations of peel off gel facial mask were made with 3 variations in the concentration of coffee fruit peel extract, namely F1 (1%), F2 (2%), and F3 (3%). Furthermore, the preparation was evaluated for 28 d of storage at room temperature (25-30 °C) and cold temperature (8 °C) which included organoleptic, pH, spreading ability, homogeneity, viscosity, dry time, and antioxidant activity.
Results: The results of the evaluation showed that F1, F2, and F3 met the requirements which included organoleptic, pH, spreading ability, homogeneity, viscosity, and dry time. The antioxidant activity of the coffee fruit peel extract was very strong (IC50 17.36 µg/ml). The antioxidant activity in the peel off gel facial mask sample of formula F1 (IC50 75.63 µg/ml) and formula F2 (IC50 50.71 µg/ml) was strong, and for formula F3 was very strong (IC50 21.44 µg/ml).
Conclusion: All formulas met the evaluation requirements, arabica coffee fruit peel extract and peel of gel facial mask preparation (F3) have very strong antioxidant activity.
OPTIMIZATION OF DILTIAZEM HYDROCHLORIDE NANOPARTICLES FORMULA AND ITS RELEASE KINETICS EVALUATION
Authors: WINARTI LINA , SARI LUSIA OKTORA RUMA KUMALA , NURAHMANTO EKA DEDDY IRAWAN DWI , ROSYIDI VIDDY AGUSTIAN , AMELIANA LIDYA , BARIKAH KUNI ZU’ AIMAH , ANJARANI REGITA ARDIA 
Published: December 2021

Objective: The purpose of this study was to determine the optimum formula of diltiazem HCl-loaded chitosan nanoparticles due to variations in the speed and duration of stirring and evaluating the release kinetics in vitro using DDSolver.
Methods: The method used to prepare nanoparticles is ionic gelation. The ionic gelation method involves an ionic cross-linking between cations on the backbone of chitosan and anion, such as sodium tripolyphosphate (Na TPP).
Results: Stirring speed of 1200 rpm and stirring time of 2 h produce an optimum response. The optimum formula has an entrapment efficiency of 71.10%, a particle size of 110.2 nm, and a polydispersity index of 0.268. The dry powder of diltiazem HCl nanoparticles produced a drug loading of 66.14±1.71% and a yield of 34.07±0.73%. The FT-IR showed ionic interaction (cross-linking) between ammonium ions from chitosan and phosphate ions from Na TPP. Scanning electron microscopy (SEM) analysis showed a particle size of 150 µm, a spherical shape, and rough surface morphology. In vitro release profiles indicated prolonged release, which follows the Korsmeyer Peppas model.
Conclusion: It can be concluded that increasing the speed and duration of stirring will improve drug entrapment and reduce the particles size variation. The dry nanoparticles release mechanism is by diffusion and matrix erosion.
MOLECULAR DOCKING AND MOLECULAR DYNAMICS STUDIES OF ACALYPHA INDICA L. PHYTOCHEMICAL CONSTITUENTS WITH CASPASE-3
Authors: FEBRINA ELLIN , ALAMHARI RYAN KHUNAM , ABDULAH RIZKY , LESTARI KERI , LEVITA JUTTI , SUPRATMAN UNANG 
Published: December 2021

Objective: This study investigated the structure-based molecular interactions between phytochemical constituents of Acalypha indica L. and caspase-3.
Methods: Thirty-three phytochemical constituents of A. indica were screened against caspase-3. The X-ray crystal structure of human caspase-3 was retrieved from https://www.rcsb.org/structure/. The molecular interactions of the phytochemicals were studied using the AutoDock 4.2 software and followed by molecular dynamics (MD) simulations using the Amber18 software.
Results: From this study, 25 screened phytochemicals were found to have a better binding mode than the native ligand. Moreover, the binding stability of the top four hits evaluated by MD indicated that the hydrogen bonds in MD were quite different from the molecular docking results due to the massive receptor and ligand movement in the MD simulations. However, with the exception of stigmasterol, all ligands were able to stabilize the protein.
Conclusion: This study suggested that γ-sitosterol acetate, β-sitosterol acetate, and γ-sitosterol might be able to induce caspase-3, thereby activating apoptosis. These high-affinity compounds can bind to caspase-3 more efficiently and were able to stabilize the protein. Therefore, they have the potential to be used as lead compounds in the treatment of cancer.
THE IMPACT OF THE DEVELOPMENT OF THE TOURIST INDUSTRY ON THE ENVIRONMENT
Authors: Yukhnovska Yulia 
Published: December 2021

The article considers the topical issue of the impact of the tourism industry on the environment.
The main goal is to analyze the current state of the environment and the impact on it of the tourism industry of Ukraine. Informative-analytical methods, comparison methods, etc. were used during the research.
The quality of the environment, both natural and artificial, is important for the tourism industry. However, the relationship of the tourism industry in Ukraine with the environment is complex. The tourism industry involves many activities that can have a negative impact on the environment. Many of these impacts are related to the construction of general infrastructure objects such as roads and airports, tourist facilities, including resorts, hotels, restaurants, shops, marinas and more. The negative consequences of the development of the tourism industry can gradually destroy the environment, the resources on which it depends.
On the other hand, the tourism industry has the potential to create a beneficial impact on the environment, contributes to the protection and preservation of the environment. It is a way to raise awareness of environmental values, and it can serve as a tool to finance the protection of natural areas and increase economic value.
The paper examines the impact of the tourism industry on natural resources, environmental pollution and the physical environment. In addition, the impact of the tourism industry on the environment on a global scale is analyzed.
The main positive and negative external effects of the development of the tourism industry of Ukraine are analyzed in the article; the essence of environmental problems of the development of the tourism industry; capital investments for environmental protection by types of environmental measures in Ukraine are analyzed; current costs for environmental protection by types of environmental measures in Ukraine and proposed ways to minimize the negative consequences of the processes “tourism industry ‒ environment”.
STRATEGIES TO INCREASE THE TOURIST ATTRACTIVENESS OF THE DECEMBRISTS PARK IN KAMIANKA
Authors: Bieliaieva Svitlana , Herman Iryna 
Published: December 2021

The paper presents historical facts about the town of Kamianka in Cherkasy region, famous historical figures that lived in this area and their guests ‒ world famous and respected. The analysis of natural resources and objects in the territory of the Decembrists Park is given, their tourist attractiveness for the organization and carrying out of excursions for tourists and wide sections of the population of Ukraine and visitors from other countries of the world is proved.
The purpose of the study is to analyze tourist resources and determine a strategy to increase the tourist attractiveness of the Decembrists Park in Kamianka.
Analytical, statistical methods, comparison methods, etc. were used during the research.
The article proves that the tourist potential of the Decembrists Park in Kamianka in Cherkasy region meets the requirements for its tourist importance at the global level and motivates to create appropriate programs for its preservation and improvement of tourist potential at the level of local government agencies, the state as a whole, and internationally.
The article summarizes the arguments on the issue of defining appropriate indicators for the development of a strategy to increase the level of tourist attractiveness of the Decembrist Park in Kamianka.
According to the results of the research, it was concluded that garden and park landscapes are not only the decoration of the respective territories, but have natural, social, historical and cultural significance for the development of communities; contribute to the promotion of tourist and sightseeing facilities; motivate to preserve the natural, historical and cultural heritage of the region.
The results of the study can be useful for workers in the field of tourism and services; scientists, teachers, students of higher educational institutions who master the specialty "Tourism", as well as for employees of museums, historical and local lore reserves, cultural and architectural institutions; local governments and state institutions of culture, art, etc.
INNOVATIONS IN THE PROCESS OF PREPARATION OF «KHOLODNOYARSKY» BORSCH
Authors: Ivashyna Liliia , Byshovets Larysa 
Published: December 2021

The paper presents an analysis of the current state of Ukrainian national cuisine and considers new technologies in the preparation of Ukrainian borsch.
The main purpose of the study is to substantiate the development of technology for cooking Kholodnoyarsky borsch, as borscht occupies one of the main places in the diet of various segments of the population.
Research and development of new technologies in the preparation of national dishes is relevant today. Increased competition in the restaurant business in Ukraine requires from the professionals to find new ways to meet the demand, develop innovative approaches to creating new food technologies and expand the range of national dishes. The study of the nature and technology of cooking allows the use of modern ingredients in creating new flavors of famous dishes.The following methods were used during the research: systematization of scientific literature and theoretical analysis to determine the status and theoretical justification of the prospects of national cuisine and expand the range of dishes, also methods of comparison, information and analytical methods, generalization method and others were used.In this article the main directions of development of new technologies in the preparation of Ukrainian borsch as a national dish of Ukraine were identified. The necessity of developing this technology as an innovation to ensure the effective operation of the restaurant business is identified and substantiated.It is concluded that the development of innovative technologies in the process of cooking of «Kholodnoyarsky» borsch is a promising direction to expand the range of national dishes. To increase the nutritional value of borsch, marigold flowers (Imereti saffron) were added to the recipe and three types of meat were combined, namely pork, veal and chicken. All products are pre-fried in a cauldron, followed by cooking until the dish is ready. Further research into the technology of cooking national dishes will accelerate the emergence of Ukrainian national cuisine to a new level.The results of the study can be useful for employees of the hotel and restaurant industry, scientists, teachers and students majoring in «Hotel and restaurant business» and «Food technology in the restaurant industry»