bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebral areas affected by unilateral acupuncture on SP3 in healthy volunteers: An explorative resting‐state fMRI study
Authors: Wang Feng , Yang Tiansong , Li Xiaoling , Liu Xiaohui , Cao Danna , Wang Delong , Yang Yan , Li Chaoran , Qu Yuanyuan , Zhao Xu , Sun Zhongren , Asakawa Tetsuya 
Published: February 2021

AbstractObjectiveThe study aimed to explore the cerebral areas with changes in regional homogeneity (ReHo) and amplitude of low‐frequency fluctuation (ALFF) values induced by effective acupuncture on the Taibai (SP3) point.MethodsIn the study, 15 healthy right‐handed volunteers (seven males and eight females, 20–35 years old) were enrolled. The average ages of the subjects were 28.0 ± 4.24 years for males and 27.4 ± 3.65 years for females. A 3.0T magnetic resonance imaging (MRI) system was used to perform resting‐state functional MRI scan after sham and effective acupuncture on the SP3 point. The differences in cerebral ReHo and ALFF values between posteffective acupuncture and postsham acupuncture were compared using the SPM 12 software.ResultsReHo values of bilateral BA18, cuneus, and BA17, along with BA41, BA22, postcentral gyrus, and BA7 on the right side, were decreased by effective SP3 acupuncture. The ALFF values of bilateral BA 30 and left parahippocampal area were increased, whereas the values of bilateral BA18, BA19, cuneus, posterior cingulate gyrus, and BA7, along with the right superior occipital lobule, postcentral gyrus, and left precuneus, were decreased.ConclusionsThe most dominant cerebral areas affected by SP3 acupuncture were bilateral visual‐related cortices (lingual gyrus, cuneus, and calcarine), along with the unilateral postcentral gyrus and superior parietal lobule. These findings may be potential explanations for the available clinical reports concerning the efficacy of SP3 acupuncture. Further clinical and experimental studies on SP3 acupuncture are required.
Understanding sustainable development flexibility: An information perspective
Authors: Yu Kangkang , Qian Cheng , Zhang Lingbo 
Published: February 2021

AbstractAlthough flexibility has been considered critical in responding to uncertainty in a business environment, few studies have explored firms' flexibility in sustainable development. To understand the nature of firms that can respond better to uncertainty in their sustainable development practices, this study defines sustainable development flexibility and investigates the mechanism underlying its formation. The study proposes a conceptual framework on the interactions of managers' environmental attitude and cognitive style, as well as firms' information integration on sustainable development flexibility. A questionnaire survey was developed to test the corresponding hypotheses, and 241 valid responses were received from middle‐ and top‐level managers in Chinese firms. The results show that (a) the higher the manager's environmental attitude, the higher the firm's information integration and greater sustainable supply chain flexibility, and (b) the more intuitive the manager's cognitive style, the greater the impact of environmental attitude on sustainable development flexibility.
Time to SARS‐CoV‐2 clearance among patients with cancer and COVID‐19
Authors: Xu Wenxin , Piper‐Vallillo Andrew J. , Bindal Poorva , Wischhusen Jonathan , Patel Jaymin M. , Costa Daniel B. , Peters Mary Linton B. 
Published: February 2021

AbstractBackgroundFor cancer patients, coronavirus disease 19 (COVID‐19) infection can lead to delays in cancer therapy both due to the infection itself and due to the need to minimize exposure to other patients and to staff. Clearance guidelines have been proposed, but expected time to clearance has not been established.MethodsWe identified all patients at a tertiary care hospital cancer center between 25 March 2020 and 6 June 2020 with a positive nasopharyngeal reverse transcriptase polymerase chain reaction (RT‐PCR) test for the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a cancer‐related visit within 3 years, and at least one follow‐up assay. We determined the time to clearance using American Society of Clinical Oncology (ASCO), the UK National Institute for Health and Care Excellence (UK‐NICE), and Centers for Disease Control and Prevention (CDC) criteria. A matched non‐cancer comparison cohort was also identified.ResultsThirty‐two cancer patients were identified. Nineteen were cleared by ASCO criteria, with estimated median time to clearance of 50 days. Fourteen patients resumed chemotherapy prior to clearance. Using UK‐NICE criteria, median time to clearance would have been 31 days, and using CDC criteria, it would have been 13 days. The matched non‐cancer cohort had similar clearance time, but with less frequent testing.ConclusionSARS‐CoV‐2 clearance times differ substantially depending on the criteria used and may be prolonged in cancer patients. This could lead to a delay in cancer care, increased use of clearance testing, and extension of infection control precautions.
Metabolic Profiling of Vasorelaxant Extract from Malvaviscus arboreus by LC/QTOF‐MS
Authors: Rodríguez‐Morales Sergio , Ocampo‐Medina Blanca , Romero‐Ceronio Nancy , Alvarado‐Sánchez Cuauhtémoc , Vilchis‐Reyes Miguel Ángel , Roa de la Fuente Luis Fernando , Ortiz‐Andrade Rolffy , Hernández‐Abreu Oswaldo 
Published: February 2021

AbstractWe aimed to develop a standardized methodology to determine the metabolic profile of organic extracts from Malvaviscus arboreus Cav. (Malvaceae), a Mexican plant used in traditional medicine for the treatment of hypertension and other illnesses. Also, we determined the vasorelaxant activity of these extracts by ex vivo rat thoracic aorta assay. Organic extracts of stems and leaves were prepared by a comprehensive maceration process. The vasorelaxant activity was determined by measuring the relaxant capability of the extract to decrease a contraction induced by noradrenaline (0.1 μM). The hexane extract induced a significant vasorelaxant effect in a concentration‐ and endothelium‐dependent manner. Secondary metabolites, such as polyunsaturated fatty acids, terpenes and one flavonoid, were annotated by liquid chromatography/quadrupole time‐of‐flight mass spectrometry (LC/QTOF‐MS) in positive ion mode. This exploratory study allowed us to identify bioactive secondary metabolites from Malvaviscus arboreus, as well as identify potentially‐new vasorelaxant molecules and scaffolds for drug discovery.
CT23 knockdown attenuating malignant behaviors of hepatocellular carcinoma cell is associated with upregulation of metallothionein 1
Authors: Ning Wanjing , Huang Miao , Wu Shengming , Wang Hong , Yao Jiali , Ge Yingying , Tang Yulu , Sun Kejian , Xie Xiaoxun , Hu Qiping 
Published: February 2021

AbstractThe cancer‐testis antigen 23 (CT23) gene has been reported in association with the pathogenesis and progress of hepatocellular carcinoma (HCC). However, the alterations of gene expression profiling induced by CT23 knockdown in HCC cells remains largely unknown. In this study, the RNA interfering (RNAi) method was used to silence CT23 expression in BEL‐7404 cells. Microarray analysis was performed on mRNA extracted from the CT23 knockdown cells and the control cells to determine the alterations of gene expression profiles. The result showed a total of 1051 genes expressed differentially (two‐fold change), including 470 genes upregulated and 581 gene downregulated in the CT23 knockdown cells. A bioinformatic analysis showed that the functional differentially expressed genes (DEGs) were linked to cell proliferation, migration, and apoptosis, and metallothionein 1 (MT1) attained the maximum enrichment scores in functional annotation, classification, and pathway analysis of DEGs. Furthermore, Western blot analysis and cell behaviors assays verified that CT23 modulates cell proliferation, migration, and apoptosis by regulating MT1 expression in HCC cells and non‐neoplastic hepatocytes. In summary, downregulated CT23 gene in BEL‐7404 cells might change the expressions of carcinogenesis and progression related genes in HCC by upregulating MT1 expression, which would provide insight into searching for a novel therapeutic target for HCC.
Transcatheter pulmonary denervation in patients with left heart failure with reduced ejection fraction and combined precapillary and postcapillary pulmonary hypertension: A prospective single center experience
Authors: Witkowski Adam , Szumowski Łukasz , Urbanek Piotr , Jastrzębski Jan , Skowroński Jarosław , Sobieszczańska‐Małek Małgorzata , Hoffman Piotr , Kowalik Ewa , Wiśniewska Joanna , Banasiak Adam , Parulski Adam , Zieliński Tomasz 
Published: February 2021

AbstractObjectivesThe present study was a prospective, single‐center, single‐arm study to investigate the efficacy of transcatheter pulmonary artery denervation (TPADN) in patients with combined postcapillary and precapillary PH (Cpc‐PH) associated with left heart failure with reduced ejection fraction (HF‐rEF).BackgroundPulmonary hypertension (PH) in patients with left ventricular systolic dysfunction has a negative impact on outcome.MethodsThe combination of pulmonary artery systolic pressure (PAPs) ≥60 mmHg, transpulmonary pressure gradient (TPG) ≥12 mmHg, nonreversible mean PAP, and pulmonary vascular resistance (PVR) ≥3.5 Wood Units was considered as too high risk for heart transplantation (HTx). The clinical efficacy endpoint was an improvement in 6‐min walking test and the hemodynamic endpoints were changes in PAPs, PVR, and TPG between baseline and 6 months. Circumferential radiofrequency applications were delivered around distal main, left and right pulmonary arteries. At each ablation point temperature was 45°C and energy 10 W.ResultsTPADN was performed in 10 patients. At 6‐month in 5 patients we observed reduction in PAP, PVR, TPG, and DPG and then 1 had successful HTx, 2 are on HTx waiting list, 2 received LVADs, 2 patients did not improve, and 3 patients died.ConclusionsTPADN may be beneficial in selected patients with HF‐rEF and Cpc‐PH.
Small Molecule Activation with Intramolecular “Inverse” Frustrated Lewis Pairs
Authors: Manankandayalage Chamila , Unruh Daniel K. , Krempner Clemens 
Published: February 2021

AbstractThe intramolecular “inverse” frustrated Lewis pairs (FLPs) of general formula 1‐BR2‐2‐[(Me2N)2C=N]‐C6H4 (3–6) [BR2=BMes2 (3), BC12H8, (4), BBN (5), BBNO (6)] were synthesized and structurally characterized by multinuclear NMR spectroscopy and X‐ray analysis. These novel types of pre‐organized FLPs, featuring strongly basic guanidino units rigidly linked to weakly Lewis acidic boryl moieties via an ortho‐phenylene linker, are capable of activating H−H, C−H, N−H, O−H, Si−H, B−H and C=O bonds. 4 and 5 deprotonated terminal alkynes and acetylene to form the zwitterionic borates 1‐(RC≡C‐BR2)‐2‐[(Me2N)2C=NH]‐C6H4 (R=Ph, H) and reacted with ammonia, BnNH2 and pyrrolidine, to generate the FLP adducts 1‐(R2HN→BR2)‐2‐[(Me2N)2C=NH]‐C6H4, where the N‐H functionality is activated by intramolecular H‐bond interactions. In addition, 5 was found to rapidly add across the double bond of H2CO, PhCHO and PhNCO to form cyclic zwitterionic guanidinium borates in excellent yields. Likewise, 5 is capable of cleaving H2, HBPin and PhSiH3 to form various amino boranes. Collectively, the results demonstrate that these new types of intramolecular FLPs featuring weakly Lewis acidic boryl and strongly basic guanidino moieties are as potent as conventional intramolecular FLPs with strongly Lewis acidic units in activating small molecules.
Metal‐Dependent and Selective Crystallization of CAU‐10 and MIL‐53 Frameworks through Linker Nitration
Authors: Rabe Timo , Svensson Grape Erik , Engesser Tobias A. , Inge A. Ken , Ströh Jonas , Kohlmeyer‐Yilmaz Gitta , Wahiduzzaman Mohammad , Maurin Guillaume , Sönnichsen Frank D. , Stock Norbert 
Published: February 2021

AbstractThe reaction of the V‐shaped linker molecule 5‐hydroxyisophthalic acid (H2L0), with Al or Ga nitrate under almost identical reaction conditions leads to the nitration of the linker and subsequent formation of metal–organic frameworks (MOFs) with CAU‐10 or MIL‐53 type structure of composition [Al(OH)(L)], denoted as Al‐CAU‐10‐L0, 2, 4, 6 or [Ga(OH)(L)], denoted as Ga‐MIL‐53‐L2. The Al‐MOF contains the original linker L0 as well as three different nitration products (L2, L4 and L4/6), whereas the Ga‐MOF mainly incorporates the linker L2. The compositions were deduced by 1H NMR spectroscopy and confirmed by Rietveld refinement. In situ and ex situ studies were carried out to follow the nitration and crystallization, as well as the composition of the MOFs. The crystal structures were refined against powder X‐ray diffraction (PXRD) data. As anticipated, the use of the V‐shaped linker results in the formation of the CAU‐10 type structure in the Al‐MOF. Unexpectedly, the Ga‐MOF crystallizes in a MIL‐53 type structure, which is usually observed with linear or slightly bent linker molecules. To study the structure directing effect of the in situ nitrated linker, pure 2‐nitrobenzene‐1,3‐dicarboxylic acid (m‐H2BDC‐NO2) was employed which exclusively led to the formation of [Ga(OH)(C8H3NO6)] (Ga‐MIL‐53‐m‐BDC‐NO2), which is isoreticular to Ga‐MIL‐53‐L2. Density Functional Theory (DFT) calculations confirmed the higher stability of Ga‐MIL‐53‐L2 compared to Ga‐CAU‐10‐L2 and grand canonical Monte Carlo simulations (GCMC) are in agreement with the observed water adsorption isotherms of Ga‐MIL‐53‐L2.
One‐Pot Synthesis of Polysubstituted Pyrroles via Sequential Ketenimine Formation/Ag(I)‐Catalyzed Alkyne Cycloisomerisation Starting from Ylide Adducts
Authors: Xiong Jun , Mu Zhi‐Ying , Yao Gang , Zhang Jia‐An , Feng Qi‐Xun , He Hui‐Ting , Pang Yong‐Long , Shi Hang , Ding Ming‐Wu 
Published: February 2021

Main observation and conclusionA simple one pot synthesis of polysubstituted pyrroles via ketenimine formation/Ag(I)‐catalyzed alkyne cycloisomerisation has been developed. The easily accessible phosphorane ylide derivatives reacted with isocyanates, producing highly active ketenimines that were then treated with amines, which afforded substituted pyrroles by a 5‐exo‐dig cyclization/isomerization in the presence of a Ag(I) catalyst in good overall yields.
Antiosteoporotic Tetrahydroxanthone Dimers from Aspergillus brunneoviolaceusFB‐2 Residing in Human Gut
Authors: Lv Xiao Jing , Ding Fei , Wei Ying Jie , Tan Ren Xiang 
Published: February 2021

Main observation and conclusionA complex community of human‐associated microorganisms plays diversely important roles in maintaining health, and the metabolites help to define whether a particular human‐associated microbe is a friend or a foe. This work shows that Aspergillus brunneoviolaceus FB‐2, derived from the stool of a healthy individual, produces a family of antiosteoporotic xanthone dimers including penibishexahydroxanthone A (1) and brunneoxanthones A—E (2—6, undescribed previously). The structures of 1—6 were elucidated by MS and NMR spectroscopic analysis, and the absolute configuration of 2 was established by X‐ray crystallography. Compounds 4—6 are relatively rare examples of highly oxidized heterodimeric xanthones with an 8‐ketone functionality. Finally, the prednisolone‐induced osteoporotic zebrafish enabled our demonstration that the antiosteoporotic effects of 1—6 are dose‐dependent.
Assessment of Soil Trace Metal Pollution in the Xuejiping Mine Area, Yunan, China
Authors: Chen Wen‐De , Yao Wen‐Wen , Huang Zhong‐Xuan , Ying Qiao‐Chu , He Zheng‐Wei 
Published: February 2021

AbstractEnvironmental pollution and risk assessment of trace metals in top soils of Xuejiping Mine in Xichang City are studied. Soil samples are collected around the mine areas. Seven trace metal elements (Hg, Cd, Pb, Cr, Cu, Zn, and As) are analyzed to evaluate the pollution status using chemical speciation, geo‐accumulation index (Igeo), and the potential ecological risk index (RI). Results indicate that concentrations of trace metal elements in the mining area exceed soil background values in Yunnan Province. Trace metal elements are ranked according to the Igeo evaluation results (indicating the degree of pollution), as: Pb > As > Cu > Hg > Zn > Cd > Cr; trace elements are ranked as > > > > > > using the ecological risk index. These results indicate that the surface soil of the Xuejiping mining area is moderately polluted by trace metal elements. Therefore, effective measures can be taken to control the trace metals pollution in the mining area (especially for Pb and Cu).
Newer Non‐ionic A2B2‐Type Enzyme‐Responsive Amphiphiles for Drug Delivery
Authors: Krishna  , Parshad Badri , Achazi Katharina , Böttcher Christoph , Haag Rainer , Sharma Sunil K. 
Published: February 2021

AbstractA new series of nonionic gemini amphiphiles have been synthesized in a multi‐step chemoenzymatic approach by using a novel A2B2‐type central core consisting of conjugating glycerol and propargyl bromide on 5‐hydroxy isophthalic acid. A pair of hydrophilic monomethoxy poly(ethylene glycol) (mPEG) and hydrophobic linear alkyl chains (C12/C15) were then added to the core to obtain amphiphilic architectures. The aggregation tendency in aqueous media was studied by dynamic light scattering, fluorescence spectroscopy and cryogenic transmission electron microscopy. The nanotransport potential of the amphiphiles was studied for model hydrophobic guests, that is, the dye Nile Red and the drug Nimodipine by using UV/Vis and fluorescence spectroscopy. Evaluation of the viability of amphiphile‐treated A549 cells showed them to be well tolerated up to the concentrations studied. Being ester based, these amphiphiles exhibit stimuli‐responsive sensitivity towards esterases, and a rupture of amphiphilic architecture was observed in the presence of immobilized Candida antarctica lipase (Novozym 435), thus facilitating release of the encapsulated guest from the aggregate.
Supported Metal Nanoparticles in Metal‐Organic Monoliths for Assembly of a Catalytic Microfluidic Reactor
Authors: Chen Junxing , Xin Yu , Wu Jinyi , Liao Peisen , Chen Liuping , Zhang Jianyong 
Published: February 2021

AbstractA novel strategy has been developed to fabricate an Au@CrADC (ADC=5‐aminobenzene‐1,3‐dicarboxylate) metal‐organic monolithic capillary in microfluidic reactors. Monolithic Cr3+‐based metal‐organic gel (MOG) as catalyst support is synthesized inside fused‐silica capillary employing a two‐step procedure including surface modification of carboxyl group to provide anchoring sites and subsequent MOG formation. Subsequently, Au nanoparticles are in situ immobilized in the monolithic MOG support as active catalysts. The resulting Au@CrADC monolithic capillary is used to assemble a catalytic microfluidic reactor. The catalytic activity of the Au@CrADC reactor is probed by using the oxidative alkyne coupling reaction to synthesize 1,3‐diynes. The catalytic microfluidic reactor demonstrates significantly enhanced catalytic activity in comparison with the corresponding reactions under batch conditions. Additionally, the microfluidic reactor shows high stability with no significant catalytic deactivation during repeated uses.
From the design of the shades to the sale of make‐up products: The contribution of the expertise of colorists during research and development
Authors: de Clermont‐Gallerande Hélène 
Published: February 2021

AbstractAt CHANEL, color is both a heritage and a source of innovation that allows them to offer approximately 350 new shades every year. The designer who creates a seasonal make‐up collection determines the shades one and a half year before the collection is launched. The inspiration is then translated into a “brief,” that is, into “words” and material samples. This must be accurate so that the scientists can transpose the colors as faithfully as possible. The colorists' work begins 15 months before the launch: Tone, undertone, opacity, brightness, and reflection. Each developed color is studied in its colorimetric composition to meet the target. Then every needed pigment proportion is determined to achieve the shade. Depending on the final application area, regulatory constraints linked to the chemical nature of the pigments present in the formula must be taken into consideration. All references are validated no later than 12 months before launch. A visual and spectrocolorimetric measurements are carried out to establish the industrial specifications for the manufacturing phase. The pilot phase focuses on the impact of the (manufactured) color quantity increase. The quality laboratory uses visual and instrumental methods to establish the conformity of supplier's pigments and finished products manufactured. Architectural design is used to showcase the color at the point of sale. During the whole process, the colorists will check and validate the colors reproducibility. Their skills are essential in make‐up industry.
Combined Gene Expression and Chromatin Immunoprecipitation From a Single Mouse Hippocampus
Authors: Helbling Jean‐Christophe , Kinouchi Kenichiro , Trifilieff Pierre , Sassone‐Corsi Paolo , Moisan Marie‐Pierre 
Published: February 2021

AbstractAll neuronal cells hold the same genetic information but vary by their structural and functional plasticity depending on the brain area and environmental influences. Such variability involves specific gene regulation, which is driven by transcription factors (TFs). In the field of neuroscience, epigenetics is the main mechanism that has been investigated to understand the dynamic modulation of gene expression by behavioral responses, stress responses, memory processes, etc. Nowadays, gene expression analyzed by real‐time quantitative PCR and TF binding estimated by chromatin immunoprecipitation (ChIP) enables one to dissect this regulation. Because of the wide range of transgenic models, as well as cost‐effective aspects, mouse models are widely used neuroscience. Thus, we have set up a protocol that allows extraction of both RNA for gene expression analysis and chromatin for ChIP experiment from a single mouse hippocampus. Using such protocols, information regarding gene expression and regulatory molecular mechanisms from the same animal can be integrated and correlated with neurobiological and behavioral outcomes. © 2021 Wiley Periodicals LLC.This article was corrected on 19 July 2022. See the end of the full text for details.Basic Protocol 1: Hippocampus isolation from mouse brainBasic Protocol 2: RNA extraction and gene expression analysis from a mouse half hippocampusBasic Protocol 3: ChIP from one hemisphere side mouse hippocampus
Towards a typology of strategic corporate social responsibility through camouflage and courtship analogies
Authors: Crotty Jo , Holt Diane 
Published: February 2021

AbstractThis paper develops a theory of strategic corporate social responsibility responses, by drawing on the analogy of biological species‐level adaptations of camouflage and courtship found in the natural world. In so doing, we focus on the substantive response and associated strategic motivation to engage in different types of CSR within a mainstreaming environment; and the mechanisms by which it occurs in differing scenarios, framed through a biological interpretative lens. We presents eight strategic approaches to CSR, each defined by a camouflage or courtship approach. Each strategy is considered through the lens of their biological comparators and published case vignettes of CSR strategies within firms. The paper concludes by discussing a future research agenda building on the theoretical framework presented.