bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advantages of score-based delirium detection compared to a clinical delirium assessment—a retrospective, monocentric cohort study
Authors: Jäckel Markus , Aicher Nico , Bemtgen Xavier , Rilinger Jonathan , Zotzmann Viviane , Biever Paul Marc , Supady Alexander , Stachon Peter , Duerschmied Daniel , Wengenmayer Tobias , Bode Christoph , Staudacher Dawid Leander 
Published: November 2021

Purpose
Delirium is an underdiagnosed complication on intensive care units (ICU). We hypothesized that a score-based delirium detection using the Nudesc score identifies more patients compared to a traditional diagnosis of delirium by ICU physicians.

Methods
In this retrospective study, all patients treated on a general medical ICU with 30 beds in a university hospital in 2019 were analyzed. Primary outcome was a documented physician diagnosis of delirium, or a delirium score ≥2 using the Nudesc.

Results
In 205/943 included patients (21.7%), delirium was diagnosed by ICU physicians compared to 438/943 (46.4%; ratio 2.1) by Nudesc≥2. Both assessments were independent predictors of ICU stay (p<0.01). The physician diagnosis however was no independent predictor of mortality (OR 0.98 (0.57–1.72); p = 0.989), in contrast to the score-based diagnosis (OR 2.31 (1.30–4.10); p = 0.004). Subgroup analysis showed that physicians underdiagnosed delirium in case of hypoactive delirium and delirium in patients with female gender and in patients with an age below 60 years.

Conclusion
Delirium in patients with hypoactive delirium, female patients and those below 60 years was underdiagnosed by physicians. The score-based delirium diagnosis detected delirium more frequently and correlated with ICU mortality and stay.
The coronavirus disease 2019 (COVID-19) vaccination psychological antecedent assessment using the Arabic 5c validated tool: An online survey in 13 Arab countries
Authors: Abdou Marwa Shawky , Kheirallah Khalid A. , Aly Maged Ossama , Ramadan Ahmed , Elhadi Yasir Ahmed Mohammed , Elbarazi Iffat , Deghidy Ehsan Akram , El Saeh Haider M. , Salem Karem Mohamed , Ghazy Ramy Mohamed 
Published: November 2021

Background
Following the emergency approval of the coronavirus disease 2019 (COVID-19) vaccines, research into its vaccination hesitancy saw a substantial increase. However, the psychological behaviors associated with this hesitancy are still not completely understood. This study assessed the psychological antecedents associated with COVID-19 vaccination in the Arab population.

Methodology
The validated Arabic version of the 5C questionnaire was distributed online across various social media platforms in Arabic-speaking countries. The questionnaire had three sections, namely, socio-demographics, COVID-19 related infection and vaccination, and the 5C scale of vaccine psychological antecedents of confidence, complacency, constraints, calculation, and collective responsibility.

Results
In total, 4,474 participants with a mean age of 32.48 ± 10.76 from 13 Arab countries made up the final sample, 40.8% of whom were male. Around 26.7% of the participants were found to be confident about the COVID-19 vaccination, 10.7% indicated complacency, 96.5% indicated they had no constraints, 48.8% had a preference for calculation and 40.4% indicated they had collective responsibility. The 5C antecedents varied across the studied countries with the confidence and collective responsibility being the highest in the United Arab Emirates (59.0% and 58.0%, respectively), complacency and constraints in Morocco (21.0% and 7.0%, respectively) and calculation in Sudan (60.0%). The regression analyses revealed that sex, age, educational degrees, being a health care professional, history of COVID-19 infection and having a relative infected or died from COVID-19 significantly predicted the 5C psychological antecedents by different degrees.

Conclusion
There are wide psychological antecedent variations between Arab countries, and different determinants can have a profound effect on the COVID-19 vaccine’s psychological antecedents.
Amyotrophic lateral sclerosis: Correlations between fluid biomarkers of NfL, TDP-43, and tau, and clinical characteristics
Authors: Kojima Yuta , Kasai Takashi , Noto Yu-ichi , Ohmichi Takuma , Tatebe Harutsugu , Kitaoji Takamasa , Tsuji Yukiko , Kitani-Morii Fukiko , Shinomoto Makiko , Allsop David , Teramukai Satoshi , Mizuno Toshiki , Tokuda Takahiko 
Published: November 2021

Objectives
We previously reported the diagnostic and prognostic performance of neurofilament light chain (NfL), TAR DNA-binding protein 43 (TDP-43), and total tau (t-tau) in cerebrospinal fluid (CSF) and plasma as amyotrophic lateral sclerosis (ALS) biomarkers. The present study aimed to elucidate associations between clinical characteristics and the markers as well as mutual associations of the markers in ALS patients using the same dataset.

Methods
NfL, TDP-43, and t-tau levels in CSF and plasma in 75 ALS patients were analyzed. The associations between those markers and clinical details were investigated by uni- and multivariate analyses. Correlations between the markers were analyzed univariately.

Results
In multivariate analysis of CSF proteins, the disease progression rate (DPR) was positively correlated with NfL (β: 0.51, p = 0.007) and t-tau (β: 0.37, p = 0.03). Plasma NfL was correlated with age (β: 0.53, p = 0.005) and diagnostic grade (β: -0.42, p = 0.02) in multivariate analysis. Plasma TDP-43 was correlated negatively with split hand index (β: -0.48, p = 0.04) and positively with % vital capacity (β: 0.64, p = 0.03) in multivariate analysis. Regarding mutual biomarker analysis, a negative correlation between CSF-NfL and TDP-43 was identified (r: -0.36, p = 0.002).

Conclusions
Elevated NfL and t-tau levels in CSF may be biomarkers to predict rapid DPR from onset to sample collection. The negative relationship between CSF NfL and TDP-43 suggests that elevation of CSF TDP-43 in ALS is not a simple consequence of its release into CSF during neurodegeneration. The negative correlation between plasma TDP-43 and split hand index may support the pathophysiological association between plasma TDP-43 and ALS.
Providers’ mediating role for medication adherence among cancer survivors
Authors: Trogdon Justin G. , Amin Krutika , Gupta Parul , Urick Benjamin Y. , Reeder-Hayes Katherine E. , Farley Joel F. , Wheeler Stephanie B. , Spees Lisa , Lund Jennifer L. 
Published: November 2021

BackgroundWe conducted a mediation analysis of the provider team’s role in changes to chronic condition medication adherence among cancer survivors.MethodsWe used a retrospective, longitudinal cohort design following Medicare beneficiaries from 18-months before through 24-months following cancer diagnosis. We included beneficiaries aged ≥66 years newly diagnosed with breast, colorectal, lung or prostate cancer and using medication for non-insulin anti-diabetics, statins, and/or anti-hypertensives and similar individuals without cancer from Surveillance, Epidemiology, and End Results-Medicare data, 2008–2014. Chronic condition medication adherence was defined as a proportion of days covered ≥ 80%. Provider team structure was measured using two factors capturing the number of providers seen and the historical amount of patient sharing among providers. Linear regressions relying on within-survivor variation were run separately for each cancer site, chronic condition, and follow-up period.ResultsThe number of providers and patient sharing among providers increased after cancer diagnosis relative to the non-cancer control group. Changes in provider team complexity explained only small changes in medication adherence. Provider team effects were statistically insignificant in 13 of 17 analytic samples with significant changes in adherence. Statistically significant provider team effects were small in magnitude (<0.5 percentage points).ConclusionsIncreased complexity in the provider team associated with cancer diagnosis did not lead to meaningful reductions in medication adherence. Interventions aimed at improving chronic condition medication adherence should be targeted based on the type of cancer and chronic condition and focus on other provider, systemic, or patient factors.
Antibiotic use for respiratory syncytial virus in the Middle East: A surveillance study in hospitalized Jordanian children
Authors: Rankin Danielle A. , Khankari Nikhil K. , Haddadin Zaid , Hamdan Olla , Yanis Ahmad , Faouri Samir , Shehabi Asem , Williams John V. , Khuri-Bulos Najwa , Halasa Natasha B. 
Published: November 2021

IntroductionIn developing countries where point-of-care testing is limited, providers rely on clinical judgement to discriminate between viral and bacterial respiratory infections. We performed a cross-sectional cohort study of hospitalized Jordanian children to evaluate antibiotic use for respiratory syncytial virus (RSV) infections.Materials and methodsAdmitting diagnoses from a prior viral surveillance cohort of hospitalized Jordanian children were dichotomized into suspected viral-like, non-pulmonary bacterial-like, and pulmonary bacterial-like infection. Stratifying by sex, we performed a polytomous logistic regression adjusting for age, underlying medical condition, maternal education, and region of residence to estimate prevalence odds ratios (PORs) for antibiotic use during hospitalization. Sensitivity and specificity of admission diagnoses and research laboratory results were compared.ResultsChildren with a suspected viral-like admission diagnosis, compared to those with suspected non-pulmonary bacterial-like, were 88% and 86% less likely to be administered an empiric/first-line antibiotic (male, aPOR: 0.12; female, aPOR: 0.14; p-value = <0.001). There were slight differences by sex with males having a lower prevalence than females in being administered an expanded coverage antibiotic; but they had a higher prevalence of macrolide administration than males with non-pulmonary bacterial-like infection. Overall, children with RSV had a 34% probability (sensitivity) of being assigned to a suspected viral-like diagnosis; whereas RSV-negative children had a 76% probability (specificity) of being assigned to a suspected pulmonary bacterial-like diagnosis.ConclusionsHospitalized children with a suspected viral-like admission diagnosis were less likely to receive an empiric/first-line and expanded coverage antibiotic compared to suspected non-pulmonary and pulmonary infections; however, when evaluating the accuracy of admission diagnosis to RSV-laboratory results there were considerable misclassifications. These results highlight the need for developing antibiotic interventions for Jordan and the rest of the Middle East.
SPATIAL STUDIES IN THE RUSSIAN REGIONALISTS WORKS: A NARRATIVE REVIEW
Authors: Trotskovsky A. Ya. 
Published: November 2021

The purpose of this article is to streamline relatively new (over the last ten-year period) information in the field of regional and spatial research for a better understanding of the subject field of regionalistics. The article was implemented in the form of a review as one of the promising types of scientific publication and generally meets international criteria and the traditions of their compilation.
Taking into account the initial stage of the study of the socio-economic space among the extensive typology of reviews used in international practice, the most common appearance is a narrative review, one of whose characteristic features is subjective selection of information.
Preference in selection of articles was given to the works of famous regionalists; At the same time, not only publications, “directly” reflect the trends in the development of socio-economic space, but also studies made by conjugate topics and disciplines.
Structuring articles were carried out on various reasons. The main grouping of publications: 1) in the context of scientific schools and personalities; 2) depending on the direction of publications disclosing certain trends in the development of socio-economic space (“differentiation — leveling” differences, “compression — expansion”, “Integration — fragmentation”).
The complexity and problems of the formation of regional and spatial research reviews are revealed, promising directions for analyzing information on spatial subjects associated with the preparation of a systematic review are shown.
A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon
Authors: Zelman Sara , Russell Michael B. , Hojat Amin , Pilichowska Monika , Olans Lori B. , Sterling Mark J. 
Published: November 2021

ABSTRACT
Waldenstrom macroglobulinemia is an uncommon mature B-cell lymphoma characterized by monoclonal immunoglobulin M protein in peripheral blood and lymphoplasmacytic cells in bone marrow and/or extramedullary sites. The gastrointestinal tract is a rare site of involvement. The diagnosis is based on clinicopathologic findings, although somatic mutations, such as MYD88, can aid in the diagnosis. We present a patient with irregular stools diagnosed with Waldenstrom macroglobulinemia involving the rectosigmoid colon by histopathology and immunohistochemistry on colonic biopsies, immunoglobulin M protein in serum, clonal plasma cells in bone marrow, and MYD88 mutation in colonic and bone marrow specimens.
Pengembangan Media Pembelajaran Edmodo Berbasis Blended Learning Berorientasi Representasi Kimia
Authors: Waroh Zahrotul Ma 
Published: November 2021

Penelitian ini bertujuan mengembangkan media pembelajaran edmodo berbasis blended learning berorientasi representasi kimia dan mengkaji kualitas produk, serta mengkaji respon peserta didik. Penelitian dilakukan dengan menggunakan model pengembangan 4-D ‎yang terdiri atas 4 tahap, yaitu define, design, development, dan disseminate. ‎Penelitian ini dibatasi sampai tahap ketiga atau development. Produk dinilai menggunakan instrumen penilaian kualitas skala Likert dan Gutmann. Produk yang ‎dikembangkan dinilaikan kepada dosen ahli media, dosen ahli materi, dan guru kimia SMA/MA dan direspon oleh peserta didik. Hasil penelitian menunjukan bahwa berdasarkan penilaian dosen ahli materi, dosen ahli media, dan guru kimia SMA/MA, produk yang dikembangkan memiliki kualitas yang sangat baik dengan presentase keidealan berturut-turut sebesar 96,42%; 77,5%; dan 80,5%. Sedangkan untuk respon peserta didiknya dikategorikan sangat baik dengan presentase keidealan sebesar 90,6%.
Identifikasi Potensi Budaya Lokal Berbasis Etnokimia Di kabupaten Bantul
Authors: Azizah Nur , Premono Shidiq 
Published: November 2021

Kebudayaan dapat dimanfaatkan sebagai sumber pembelajaran, misalnya etnokimia sehingga keberadaannya tetap terjaga. Etnokimia merupakan pembelajaran kimia yang dikaitkan dengan budaya. Penelitian ini bertujuan untuk mengkaji potensi budaya lokal Kabupaten Bantul bidang industri kerajinan berbasis etnokimia dan mengkaji keterkaitan antara potensi budaya lokal Kabupaten Bantul bidang industri kerajinan dengan pembelajaran kimia. Penelitian yang dilakukan adalah penelitian deskriptif kualitatif. Teknik pengumpulan data pada penelitian ini adalah observasi, wawancara, dan studi pustaka. Keabsahan data yang digunakan adalah uji kredibilitas dengan triangulasi data, uji dependabilitas, dan uji konfirmabilitas. Adapun teknik analisa data menggunakan metode Miles Huberman berupa reduksi data, penyajian data, dan penarikan kesimpulan. Data yang terkumpul dikategorisasikan dan disusun secara sistematis kemudian dibuat kesimpulan. Hasil penelitian menunjukkan bahwa potensi budaya lokal Kabupaten dapat dijadikan sebagai sumber pembelajaran berbasis kimia. Potensi budaya lokal berbasis etnokimia di Kabupaten Bantul adalah kerajinan batik, keris, gamelan, dan wayang kulit. Batik dapat dikaitkan dengan materi larutan asam basa, ikatan kimia, konsep mol, dan tata nama kimia. Keris dapat dikaitkan dengan materi sel volta dan korosi serta kimia unsur (periode 4). Gamelan dapat dikaitkan dengan materi reaksi oksidasi dan reduksi serta kimia unsur (periode 4). Wayang kulit dapat dikaitkan dengan materi polimer dan koloid.
Apuntes sobre la investigación en la universidad
Authors: Suzunaga Quintana Juan Carlos 
Published: November 2021

¿Qué es investigación? Es una pregunta que está desapareciendo de la acade- mia, en virtud de que se parte cada vez de la obviedad. No obstante, aun resue- na esta pregunta, ya no en las aulas, sino, en los corredores de la universidad, y vuelve a cobrar su verdor en los debates que se llevan a cabo en el campus universitario.
En estos apuntes quisiera ponerla nuevamente a circular. Hacer de una editorial, par- te del campus, un lugar de la universidad más allá de las aulas, pero vinculado a estas.
Epsilon-Efficiency in a Dynamic Partnership with Adverse Selection and Moral Hazard
Authors: Cao Vi 
Published: November 2021

Abstract
For a dynamic partnership with adverse selection and moral hazard, we design a direct profit division mechanism that satisfies ϵ-efficiency, periodic Bayesian incentive compatibility, interim individual rationality, and ex-post budget balance. In addition, we design a voting mechanism that implements the profit division rule associated with this direct mechanism in perfect Bayesian equilibrium. For establishing these possibility results, we assume that the partnership exhibits intertemporal complementarities instead of contemporaneous complementarities; equivalently, an agent’s current effort affects other agents’ future optimal efforts instead of current optimal efforts. This modelling assumption fits a wide range of economic settings.
Effectiveness of line type and cross type piezoelectric patches on active vibration control of a flexible rectangular plate
Authors: Atul  , Deepak G. Divya 
Published: November 2021

AbstractIn the present work, vibration control of a simply supported plate with line type and cross type piezoelectric (PZT) patches are investigated with and without actuation voltage. The plate is modeled under the assumption of Kirchhoff’s Plate theory. The mass of PZT patches remain constant in all cases. In case of actuation, applied voltage considered are 1, 2 and 3 mV. The external excitation to the plate is in the form of harmonically varying point load of 1 mN. It is noticed that cross type PZT patch is more effective in deflection suppression of plate than that of line type PZT patch at 3 mV of actuation at patch thickness of 0.75 μm. Suppression of central deflection of plate for line type and cross type PZT patches are obtained in different frequency bands of (175–185 Hz) and (870–880 Hz) respectively.
Modelling and numerical synchronization of chaotic system with fractional-order operator
Authors: Owolabi Kolade M. 
Published: November 2021

Abstract
Numerical solution of nonlinear chaotic fractional in space reaction–diffusion system is considered in this paper on a large but finite spatial domain size x ∈ [0, L] for L ≫ 0, x = x(x, y) and t ∈ [0, T]. The classical order chaotic ordinary differential equation is formulated by introducing the second-order spatial fractional derivative with order β ∈ (1, 2]. This second order spatial derivative is modelled by using the definition of the Riesz fractional derivative. The method of approximation combines the Fourier spectral method with the novel exponential time difference schemes. The proposed technique is known to have gained spectral accuracy over finite difference schemes. Applicability and suitability of the suggested methods are tested on Rössler chaotic system of recurring interests in one and two dimensions.
Weighted pseudo asymptotically Bloch periodic solutions to nonlocal Cauchy problems of integrodifferential equations in Banach spaces
Authors: Chang Yong-Kui , Zhao Jianguo 
Published: November 2021

AbstractThis paper is mainly concerned with some new asymptotic properties on mild solutions to a nonlocal Cauchy problem of integrodifferential equation in Banach spaces. Under some well-imposed conditions on the nonlocal Cauchy, the neutral and forced terms, respectively, we establish some existence results for weighted pseudoS-asymptotically (ω,k)-Bloch periodic mild solutions to the referenced equation onR+${\mathbb{R}}_{+}$by suitable superposition theorems. The results show that the strict contraction of the nonlocal Cauchy and the neutral terms with the state variable has an appreciable effect on the existence and uniqueness of such a solution compared with the forced term. As an auxiliary result, the existence of weighted pseudoS-asymptotically (ω,k)-Bloch periodic mild solutions is deduced under the sublinear growth condition on the force term with its state variable. The existence of weighted pseudoS-asymptoticallyω-antiperiodic mild solution is also obtained as a special example.
Deutsch für das Studium digital vermitteln – Didaktische Konzeption und studentische Perspektiven
Authors: Ide Robin , Rahn Stefan , Röder Sophia , Rüger Antje , Zacharias Teres 
Published: November 2021

Zusammenfassung
Der Artikel stellt ein digitales Lehrangebot zur akademischen Sprachverwendung von Deutsch für internationale Studierende vor. Ausgehend von einigen didaktisch-konzeptionellen Überlegungen werden die Online-Materialien und Lernaktivitäten überblicksartig beschrieben und anhand einer Unterrichtssequenz zum mündlichen Präsentieren exemplarisch beleuchtet. Anschließend werden die Ergebnisse einer qualitativen Interviewstudie mit sieben ehemaligen Studierenden vorgestellt, in der das digitale Lehrangebot evaluiert wurde.
The Underlying Values of Data Ethics Frameworks: A Critical Analysis of Discourses and Power Structures
Authors: Häußler Helena 
Published: November 2021

Abstract
A multitude of ethical guidelines and codes of conduct have been released by private and public organizations during the past years. Those abstract statements serve as a response to incidents of discriminatory algorithms and systems and have been quantitatively investigated for the proclaimed principles. The current study focuses on four frameworks designed for application during the development of new technologies. The purpose is to identify values and value conflicts and consider how these are represented in relation to established discourses, practices, and attitudes in Computer and Information Ethics. This helps to understand to what extent the frameworks contribute to social change. Critical Discourse Analysis according to Fairclough is used to examine language and discourses, and review edition and publication processes. Well-established values like transparency, non-maleficence, justice, accountability, and privacy were detected whereas value conflicts were barely addressed. Interestingly, the values were more often framed by a business, and technology discourse than an ethical discourse. The results suggest a hegemonic struggle between academia and tech industry whereas power asymmetries between developers and stakeholders are reinforced. It is recommended to extend stakeholder participation from the beginning and emphasize value conflicts. This can contribute to advance the field and effectively encourage a public debate about the desired technological progress.
AMBRA1 attenuates the proliferation of uveal melanoma cells
Authors: Zhao Binbin , Yang Yun , Cun Biyun , Chen Ping 
Published: November 2021

Abstract
Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults with high metastasis rates. D-type cyclins (CCNDs) are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer. Recently, the E3 ligase adaptor, autophagy and beclin 1 regulator 1 (AMBRA1), was reported to regulate the stability of CCNDs, including CCND1, but its role in UVM has not been demonstrated. AMBRA1 is lowly expressed in UVM cells, and the ablation of AMBRA1 promotes the proliferation of 92.1 and OMM1 cells, whereas ectopically expressing AMBRA1 attenuates the proliferation of UVM cells. Further studies found that AMBRA1 promotes the ubiquitination and degradation of CCND1, and AMBRA1 regulates the proliferation of UVM cells in a CCND1-dependent manner. Thus, this study suggests that AMBRA1 serves as an important tumor suppressor by limiting UVM cell growth.