bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subducting oceanic basement roughness impacts on upper-plate tectonic structure and a backstop splay fault zone activated in the southern Kodiak aftershock region of the Mw 9.2, 1964 megathrust rupture, Alaska
Authors: Krabbenhoeft Anne , von Huene Roland , Miller John J. , Klaeschen Dirk 
Published: February 2021

AbstractIn 1964, the Alaska margin ruptured in a giant Mw 9.2 megathrust earthquake, the second largest during worldwide instrumental recording. The coseismic slip and aftershock region offshore Kodiak Island was surveyed in 1977–1981 to understand the region’s tectonics. We re-processed multichannel seismic (MCS) field data using current standard Kirchhoff depth migration and/or MCS traveltime tomography. Additional surveys in 1994 added P-wave velocity structure from wide-angle seismic lines and multibeam bathymetry. Published regional gravity, backscatter, and earthquake compilations also became available at this time.Beneath the trench, rough oceanic crust is covered by ∼3–5-km-thick sediment. Sediment on the subducting plate modulates the plate interface relief. The imbricate thrust faults of the accreted prism have a complex P-wave velocity structure. Landward, an accelerated increase in P-wave velocities is marked by a backstop splay fault zone (BSFZ) that marks a transition from the prism to the higher rigidity rock beneath the middle and upper slope. Structures associated with this feature may indicate fluid flow. Farther upslope, another fault extends &gt;100 km along strike across the middle slope. Erosion from subducting seamounts leaves embayments in the frontal prism.Plate interface roughness varies along the subduction zone. Beneath the lower and middle slope, 2.5D plate interface images show modest relief, whereas the oceanic basement image is rougher. The 1964 earthquake slip maximum coincides with the leading and/or landward flank of a subducting seamount and the BSFZ. The BSFZ is a potentially active structure and should be considered in tsunami hazard assessments.
UK paediatric oncology Pneumocystis jirovecii pneumonia surveillance study
Authors: Proudfoot Rebecca Hilary , Phillips Bob 
Published: February 2021

BackgroundPneumocystis jirovecii pneumonia (PJP) is a serious infective complication of immunosuppressive therapy. There are insufficient data concerning the incidence or mortality rate in children undergoing treatment for malignancies and how these may be influenced by prophylaxis.ObjectiveProspective collection of clinical information for all suspected and proven cases of PJP in children with cancer in the UK and Ireland.DesignA surveillance survey was undertaken using a key contact at each paediatric oncology Principle Treatment Centre (PTC).Main outcome measuresTo describe the mortality, outcomes and use of prophylaxis in this at-risk group.ResultsThe study confirms that PJP is rare, with only 32 cases detected in the UK over a 2-year period reported from all 20 PTCs. No deaths were directly attributed to PJP, in contrast to previously reported high mortality rates. Breakthrough infection may occur despite prescription of ostensibly adequate prophylaxis with co-trimoxazole; 11 such cases were identified. Six infections occurred in patients for whom prophylaxis was not thought to be indicated. Two infections occurred in patients for whom prophylaxis was specifically omitted due to concerns about potential bone marrow suppression or delayed engraftment.ConclusionPJP in children treated for malignant disease is rare. Breakthrough infection despite prophylaxis with co-trimoxazole may represent pathogen resistance or non-compliance. Further consideration of the use of PJP prophylaxis during acute myeloid leukaemia and non-Hodgkin’s lymphoma treatment is warranted, alongside appraisal of the clinical implications of the possible marrow suppressive effects of co-trimoxazole and its interactions with methotrexate.
Bidirectional temporal relationship between obesity and hyperinsulinemia: longitudinal observation from a Chinese cohort
Authors: Xu Chao , Zhou Guangshuai , Zhao Meng , Zhang Xu , Fang Li , Guan Qingbo , Zhang Haiqing , Gao Ling , Zhang Tao , Zhao Jiajun 
Published: February 2021

IntroductionAlthough obesity and hyperinsulinemia are closely intercorrelated, their temporal sequence is still uncertain. This study aims to investigate the temporal relationship patterns between obesity measures and hyperinsulinemia in Chinese adults.Research design and methodsThe longitudinal cohort consisted of 2493 participants (860 males and 1633 female, mean age 56.71 years at follow-up) for whom measurements of obesity and hyperinsulinemia measures were collected twice between 2011 and 2014, with an average follow-up time of 3 years. Cross-lagged panel analysis was used to examine the temporal relationship between obesity measures (body mass index (BMI); waist circumference (WC); hip circumference (HC); waist-to-hip ratio (WHR)) and hyperinsulinemia (insulin, homeostasis model assessment of insulin resistance (HOMA-IR), or homeostasis model assessment of beta cell function (HOMA-%β)).ResultsAfter the adjustment of age, sex, smoking, drinking and follow-up years, in the BMI-insulin model, the path coefficient (β2=0.229; p<0.001) of baseline BMI to follow-up insulin was significantly greater than the path coefficient (β1=0.073; p<0.001) of baseline insulin to follow-up BMI (p<0.001 for β2>β1). In the WHR-insulin model, the path coefficient (β1=0.152; p<0.001) of baseline insulin to follow-up WHR was significantly greater than the path coefficient (β2=0.077; p<0.001) of baseline WHR to follow-up insulin (p=0.007 for β1>β2). In the WC/HC-insulin model, the path coefficients of baseline insulin to follow-up WC or HC (β1s) were also greater than the path coefficients of baseline WC or HC to follow-up insulin (β2s), but the difference between β1sand β2swere not significant. The similar temporal patterns were founded between obesity measures with HOMA-IR or HOMA-%β.ConclusionsThese findings indicate that there is a bidirectional relationship between obesity and hyperinsulinemia, and abdominal obesity measures are more sensitive to hyperinsulinemia measures than BMI.
Impact of COVID-19 on female fertility: a systematic review and meta-analysis protocol
Authors: Li Fangyuan , Lu Hua , Zhang Qi , Li Xinyun , wang Tong , Liu Qianchen , Yang Qian , Qiang Lingxia 
Published: February 2021

IntroductionThe increased social and economic burden caused by the novel COVID-19 outbreak is gradually becoming a worrisome issue for the health sector. The novel coronavirus invades the target cell by binding to ACE2, which is widely expressed in the ovaries, uterus, vagina and placenta. Significantly, the SARS-CoV-2 is said to interrupt female fertility through regulating ACE2. Thus, it is essential to investigate if the novel COVID-19 hampers female fertility, given that there is no systematic and comprehensive evidence on the association of COVID-19 with female fertility.Methods and analysisWe will systematically search cohort studies, cross-sectional studies, case–control studies and self-controlled case series designs in the following databases: Web of Science, PubMed, EMBASE, Cochrane Library, Ovid, EBSCO, WHO COVID-19 Database, Chinese Biomedical Databases, China National Knowledge Internet, VIP and WanFang Database. Medical Subject Headings and free-text terms for “COVID-19” AND “female” AND “fertility” will be performed. Eligibility criteria are as follows: population (female patients aged 13–49 years); exposure (infection with SARS-CoV-2); comparison (population without SARS-CoV-2 infections or latent SARS-CoV-2 infections); and outcome (female fertility, such as ovarian reserve function, uterine receptivity, oviducts status and menstruation status). Article screening and data extraction will be undertaken independently by two reviewers, and discrepancies will be resolved through discussion. We will use the I2statistics to assess the heterogeneity and perform a meta-analysis when sufficiently homogeneous studies are provided. Otherwise, a narrative synthesis will be performed. We will explore the potential sources of heterogeneity using subgroup analyses and meta-regression.Ethics and disseminationFormal ethical approval is not required, and findings will be published in a peer-reviewed journal.PROSPERO registration numberCRD42020189856.
Greenness may improve lung health in low–moderate but not high air pollution areas: Seven Northeastern Cities’ study
Authors: Zhou Yang , Bui Dinh S , Perret Jennifer L , Lowe Adrian J , Lodge Caroline J , Markevych Iana , Heinrich Joachim , Bloom Michael S , Knibbs Luke D , Jalaludin Bin , Yang Bo-Yi , Yu Hong-Yao , Zeng Xiao-Wen , Yu Yunjiang , Dharmage Shyamali C , Dong Guang-Hui 
Published: February 2021

Introduction
There is growing interest in the impact of greenness exposure on airway diseases, but the impact of greenness on lung function in children is limited. We aimed to investigate the associations between greenness surrounding schools and lung function in children and whether these associations are modified by air pollution exposure.

Methods

Between 2012 and 2013, a cross-sectional survey and spirometry were performed among 6740 school children. Lung function patterns were determined as obstructive forced expiratory volume 1 s/forced vital capacity (FEV
1
/FVC <0.8) or restrictive (FEV
1
/FVC ≥0.8 but FVC <80% of predicted). School greenness was defined by Normalized difference vegetation index (NDVI) and soil-adjusted vegetation index. Nitrogen dioxide, sulphur dioxide and particular matter concentrations were assessed using a spatiotemporal model and national monitoring data. Two-level generalised linear models were used to investigate associations and interactions.

Results

Overall, an IQR in NDVI within 500 m was associated with higher FEV
1
(+57 mL 95% CI 44 to 70) and FVC (+58 mL 95% CI 43 to 73). NDVI was similarly associated with 25% reduced odds of spirometric restriction (OR: 0.75, 95% CI 0.65 to 0.86). However, among children exposed to the highest compared with the lowest quartile of particulate matter, increasing NDVI was paradoxically associated with lower −40 mL FVC (95% CI −47 to –33, p
interaction
<0.05).

Discussion
Our findings suggest that, in this study population, greening urban areas may promote lung health in low–moderate pollution areas but not in high air pollution areas. If the findings are replicated in other moderate-to-high pollution settings, this highlights a need to have a flexible green policy.
On quantum corrections to geodesics in de-Sitter spacetime
Authors: Emelyanov Viacheslav A. 
Published: February 2021

AbstractWe find a coordinate-independent wave-packet solution of the massive Klein–Gordon equation with the conformal coupling to gravity in the de-Sitter universe. This solution can locally be represented through the superposition of positive-frequency plane waves at any space-time point, assuming that the scalar-field mass M is much bigger than the de-Sitter Hubble constant H. The solution is also shown to be related to the two-point function in the de-Sitter quantum vacuum. Moreover, we study the wave-packet propagation over cosmological times, depending on the ratio of M and H. In doing so, we find that this wave packet propagates like a point-like particle of the same mass if $$M \ggg H$$

M
⋙
H

, but, if otherwise, the wave packet behaves highly non-classically.
Preclinical Assessment of AMG 596, a Bispecific T-cell Engager (BiTE) Immunotherapy Targeting the Tumor-specific Antigen EGFRvIII
Authors: Sternjak Alexander , Lee Fei , Thomas Oliver , Balazs Mercedesz , Wahl Joachim , Lorenczewski Grit , Ullrich Ines , Muenz Markus , Rattel Benno , Bailis Julie M. , Friedrich Matthias 
Published: February 2021

Abstract
AMG 596 is a bispecific T-cell engager (BiTE) immuno-oncology therapy in clinical development for treatment of glioblastoma multiforme (GBM), the most common primary brain tumor in adults with limited therapeutic options. AMG 596 is composed of two single-chain variable fragments that simultaneously bind to the tumor-specific antigen, EGFR variant III (EGFRvIII), on GBM cells and to CD3 on T cells, thereby activating T cells to proliferate and secrete cytotoxic substances that induce lysis of the bound tumor cell. T-cell–redirected lysis by AMG 596 is very potent; in vitro studies revealed EC50 values in the low picomolar range, and in vivo studies showed that AMG 596 treatment significantly increased the overall survival of mice bearing EGFRvIII-expressing orthotopic tumors. In addition, AMG 596 activity is highly specific; no AMG 596–induced T-cell activity can be observed in assays with EGFRvIII-negative GBM cells, and no signs of toxicity and activity were observed in cynomolgus monkeys, which lack expression of EGFRvIII on normal tissues. With EGFRvIII-expressing GBM cells, we showed shedding of EGFRvIII-containing membrane vesicles, followed by vesicle uptake and EGFRvIII cell surface presentation by EGFRvIII noncoding GBM cells. Cell membrane presentation of EGFRvIII following microvesicle transfer allows engagement by AMG 596, resulting in T-cell activation and T-cell–dependent lysis of GBM cells. Together, these data show a compelling preclinical efficacy and safety profile of AMG 596, supporting its development as a novel immunotherapy for treatment of GBM.
The Kosovo Specialist Chambers and Specialist Prosecutor’s Office Paradox
Authors: Mucaj Avdylkader 
Published: February 2021

Abstract
In August 2015 the Assembly of Kosovo, following an international request, passed constitutional amendments and the Law on Specialist Chambers and Specialist Prosecutor’s Office [‘the Law’], marking the legal foundation of the Kosovo Specialist Chambers and the Specialist Prosecutor’s Office (‘the Specialist Chambers’). However, what has sparked widespread reaction in Kosovo is the narrow jurisdiction of the Specialist Chambers. Therefore, this article argues first that the Specialist Chambers have mono-ethnic jurisdiction, being charged with investigating and prosecuting only one warring party and effectively granting an amnesty to the other. Next it will be argued that the current jurisdiction of the Specialist Chambers ought to be extended to cover all mass atrocities committed during and after the Kosovo war by all warring parties. Finally, the article briefly discusses the indictment against the President of Kosovo, Hashim Thaçi, and others vis-á-vis the rejection of the main allegation of the Marty Report, on organ trafficking.
Black Robes and the Book of Heaven
Authors: Bremer Thomas S. 
Published: February 2021

Abstract
Protestant and Catholic sources tell different stories about four Nez Perce emissaries from beyond the Rocky Mountains who arrived in St. Louis in the fall of 1831. Although their respective historical accounts reveal little about why native peoples would find it advantageous to send a delegation to an American frontier town asking for help, they reveal much about the contrasts between these rival groups of American Christians in the nineteenth century as well as their common objectives in Christianizing the American west. A third version of Christian missionaries arriving in the intermountain west from an indigenous oral tradition offers a different interpretation of Christianity’s consequences for the native peoples of the region.
The Primitive Church Revived
Authors: Mitchell William H.F. 
Published: February 2021

Abstract
Recent scholarship has highlighted the religious dimensions of political argument in William III’s England. This article adds to this trend through a political analysis of pieces on the Apostolic Age that were written, re-printed, or cited, in the reign of William III. The Age was manipulated to legitimise the Williamite settlement in two ways. First, the early Christians’ ecclesiastical structures and practices were compared favourably to the contemporary Church of England, and unfavourably with Roman Catholic regimes. This contrast bolstered the bipolar confessional divide that underpinned William III’s claim to the English throne. Second, the supposed pan-national spiritual sympathy of the early Christians was regarded as a template for contemporary European Protestants, who were worthy of the protection that formed the bedrock of William III’s foreign policy.
Temporal–Spatial Variations of Atmospheric Static Stability: A Comparison of the Influences from Temperature and Its Vertical Difference
Authors: Lu Er , Hao Jiawei , Yang Kexin 
Published: February 2021

AbstractThe temporal–spatial variations of the static stability of dry air and the relative importance of their influencing quantities are explored. Derivation shows that while it links to the vertical difference of temperature, static stability also relates to the temperature itself. The static stability is expressed as a nonlinear function of temperature and the vertical difference of temperature. The relative importance of the two influencing quantities is assessed with linear regression. Tests show that the linear fitting method is robust. The results of the dominance rely on the data examined, which include an interannual variation, a seasonal variation, and a spatial variation that consists of the grid points over the globe. It is revealed that in the lower troposphere, while the temporal variations of static stability are dominated by the vertical difference of temperature, the temperature itself may also have considerable influence, especially over the high latitudes of the two hemispheres. In the stratosphere, temperature tends to have more contributions. Over the Antarctic, temperature dominates the seasonal and interannual variations of the static stability. The spatial variation of the static stability of July is influenced by both temperature and its vertical difference before 1980, but after that it is dominated by temperature.
On the Role of Bottom Pressure Torques in Wind-Driven Gyres
Authors: Stewart Andrew L. , McWilliams James C. , Solodoch Aviv 
Published: February 2021

AbstractPrevious studies have concluded that the wind-input vorticity in ocean gyres is balanced by bottom pressure torques (BPT), when integrated over latitude bands. However, the BPT must vanish when integrated over any area enclosed by an isobath. This constraint raises ambiguities regarding the regions over which BPT should close the vorticity budget, and implies that BPT generated to balance a local wind stress curl necessitates the generation of a compensating, nonlocal BPT and thus nonlocal circulation. This study aims to clarify the role of BPT in wind-driven gyres using an idealized isopycnal model. Experiments performed with a single-signed wind stress curl in an enclosed, sloped basin reveal that BPT balances the winds only when integrated over latitude bands. Integrating over other, dynamically motivated definitions of the gyre, such as barotropic streamlines, yields a balance between wind stress curl and bottom frictional torques. This implies that bottom friction plays a nonnegligible role in structuring the gyre circulation. Nonlocal bottom pressure torques manifest in the form of along-slope pressure gradients associated with a weak basin-scale circulation, and are associated with a transition to a balance between wind stress and bottom friction around the coasts. Finally, a suite of perturbation experiments is used to investigate the dynamics of BPT. To predict the BPT, the authors extend a previous theory that describes propagation of surface pressure signals from the gyre interior toward the coast along planetary potential vorticity contours. This theory is shown to agree closely with the diagnosed contributions to the vorticity budget across the suite of model experiments.
Altered pulmonary blood volume distribution as a biomarker for predicting outcomes in COVID-19 disease
Authors: Morris Michael F. , Pershad Yash , Kang Paul , Ridenour Lauren , Lavon Ben , Lanclus Maarten , Godon Rik , De Backer Jan , Glassberg Marilyn K. 
Published: February 2021

IntroductionEvidence suggests that vascular inflammation and thrombosis may be important drivers of poor clinical outcomes in patients with COVID-19. We hypothesised that a significant decrease in the percentage of blood volume in vessels with a cross-sectional area between 1.25 and 5 mm2relative to the total pulmonary blood volume (BV5%) on chest computed tomography (CT) in COVID-19 patients is predictive of adverse clinical outcomes.MethodsWe performed a retrospective analysis of chest CT scans from 10 hospitals across two US states in 313 COVID-19-positive and 195 COVID-19-negative patients seeking acute medical care.ResultsBV5% was predictive of outcomes in COVID-19 patients in a multivariate model, with a BV5% threshold below 25% associated with OR 5.58 for mortality, OR 3.20 for intubation and OR 2.54 for the composite of mortality or intubation. A model using age and BV5% had an area under the receiver operating characteristic curve of 0.85 to predict the composite of mortality or intubation in COVID-19 patients. BV5% was not predictive of clinical outcomes in patients without COVID-19.ConclusionsThe data suggest BV5% as a novel biomarker for predicting adverse outcomes in patients with COVID-19 seeking acute medical care.
Microbial and clinical factors are related to recurrence of symptoms after childhood lower respiratory tract infection
Authors: de Koff Emma M. , Man Wing Ho , van Houten Marlies A. , Vlieger Arine M. , Chu Mei Ling J.N. , Sanders Elisabeth A.M. , Bogaert Debby 
Published: February 2021

Childhood lower respiratory tract infections (LRTI) are associated with dysbiosis of the nasopharyngeal microbiota, and persistent dysbiosis following the LRTI may in turn be related to recurrent or chronic respiratory problems.Therefore, we aimed to investigate microbial and clinical predictors of early recurrence of respiratory symptoms as well as recovery of the microbial community following hospital admission for LRTI in children.To this end, we collected clinical data and characterised the nasopharyngeal microbiota of 154 children (4 weeks–5 years old) hospitalised for a LRTI (bronchiolitis, pneumonia, wheezing illness or mixed infection) at admission and 4–8 weeks later. Data were compared to 307 age-, sex- and time-matched healthy controls.During follow-up, 66% of cases experienced recurrence of (mild) respiratory symptoms. In cases with recurrence of symptoms during follow-up, we found distinct nasopharyngeal microbiota at hospital admission, with higher levels ofHaemophilus influenzae/haemolyticus, Prevotella orisand other gram-negatives and lower levels ofCorynebacterium pseudodiphtheriticum/propinquumandDolosigranulum pigrumcompared with healthy controls. Furthermore, in cases with recurrence of respiratory symptoms, recovery of the microbiota was also diminished. Especially in cases with wheezing illness, we observed a high rate of recurrence of respiratory symptoms, as well as diminished microbiota recovery at follow-up.Together, our results suggest a link between the nasopharyngeal microbiota composition during LRTI and early recurrence of respiratory symptoms, as well as diminished microbiota recovery after 4–8 weeks. Future studies should investigate whether (speed of) ecological recovery following childhood LRTI is associated with long-term respiratory problems.