bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH INFORMASI LABA DAN ARUS KAS TERHADAP HARGA SAHAM PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Yunus Muhammad Haekal , Abdullah Abdullah 
Published: October 2021

AbstrakPenelitian ini bermaksud untuk mengetahui pengaruh informasi laba dan arus kas terhadap harga saham perusahaan manufaktur. Metode analisis data yang dipakai untuk menguji hipotesis pada penelitian ini adalah Regresi Linear Berganda serta Teknik Sampel Datanya adalah purposife sampling. Hasil penelitian membuktikan bahwa informasi laba serta arus kas berpengaruh positif kepada harga saham. dengan cara parsial informasi laba berpengaruh secara signifikan kepada harga saham pada tingkat of significance kurang dari 5% , sebaliknya arus kas tidak mempengaruhi harga saham pada tingkat of significance lebih dari 5%, secara simultan terbukti berpengaruh secara signifikan kepada harga saham industri manufaktur di Bursa Efek Indonesia pada tingkat kurang dari 5%. Informasi laba dipakai oleh penanam modal buat memperkirakan harga saham industri pada industri manufatur yang listing di Bursa Efek Indonesia pada rentang waktu 2015–2019. Adapun arus kas menunjukkan pengaruh yang lemah. Kemampuan prediksi dari variabel laba dan arus kas kepada harga saham sebesar 21,8%.Kata kunci: Laba, Arus Kas, Harga Saham AbstractThis study aims to determine the effect of earnings and cash flow information on stock prices of manufacturing companies. The data analysis method used to test the hypothesis in this study was Multiple Linear Regression and the data sample technique was purposive sampling. The research results prove that earnings information and cash flow have a positive effect on stock prices. by means of partial earnings information has a significant effect on stock prices at a level of significance of less than 5%, on the other hand cash flows do not affect stock prices at a level of significance of more than 5%, simultaneously it is proven to have a significant effect on stock prices of the manufacturing industry on the Stock Exchange. Indonesia at a rate of less than 5%. Investors use earnings information to estimate industrial stock prices in manufacturing industries listed on the Indonesia Stock Exchange in the 2015–2019 timeframe. Meanwhile, cash flow shows a weak influence. The predictive ability of the earnings and cash flow variables to the stock price is 21.8%.Keywords: Profit, Cash Flow, Stock Price
التَّمَاسُكُ النَّصِّيُّ وَأَهَمِّيَّتُهُ فِي تَحْلِيلِ الْخِطَابِ الْقُرْآنِيِّ (سُورَةُ الْفُرْقَانِ نَمُوذَجًا) دراسة نحْويّة نصيّة
Authors: النجار فكري 
Published: October 2021

تشيرالدراسة إلى أهمية التماسك النصي في تحليل الخطاب القرآني، متخذةً سورة الفرقان نموذجًا للتحليل، وبانتهائها قرّ في النفس أن التماسك النصي يعد المنظم الدلالي في هذه السورة التي تتمحور آياتها حول فكرة التوحيد، وعظمة القرآن في الرد على مطاعن الكفار في النبوة، وبيان صفات عباد الرحمن، وقد جُدِلَت آياتها بأدوات التماسك النصي، كالإحالة، والربط، والحذف، والاستبدال، والرتبة، وغيرها. وبيَّنَت مفهوم التماسك النصي، وغايته، وأدواته، ثم تناولت سورة الفرقان بالدرس والتحليل، وأشارت إلى دور الإحالة بنوعيْها في تحليل النص الكريم، وبيان تماسكه. وكيف أسهم الربط بين الصلة والموصول، والمبتدأ والخير، والحال وصاحبها، والشرط وجوابه، والمعطوف والمعطوف عليه، في التماسك النصي، وكذلك التقديم والتأخير، والحذف عند وجود الدليل، وكثرة الاستعمال، وثقافة المتلقي ووعيه.
الطب الشعبي والطبابة في الإمارات العربية المتحدة خلال العصر المعاصر
Authors: الكندي خولة , شترة خير الدين 
Published: October 2021

مرَّ الطب الشعبي في منطقة الإمارات المتحدة بعدة مراحل تاريخية حيث انتقل قديماً من طب تقليدي مشحون بالوثنية والهرطقة -وهو المتوارث في أغلبه- من التراث الطبي للشعوب المجاورة إلى طب تقليدي إسلامي منهجه الهدي النبوي، ومع مرور الزمن تلاقح هذا الطب بتجارب إنسانية أخرى، وبهذا الرصيد الطبي الزاخر احترف الإماراتيون مثل غيرهم مهنة الطب الشعبي وبعض الممارسات الصحية التي أسهمت بشكل مؤثر في علاج الكثير من الأمراض التي كانت مستشرية حينها.
وغايتنا في ذلك هو محاولة الاستفادة من المساهمة النظرية والتطبيقية للإماراتيين الأوائل في مجال التداوي والصناعة الطبية والعادات الصحية، وكذا محاولة الاستثمار في هذا التراث الصحي والوقائي، والرصيد السلوكي السليم بما يفيد حاضرنا ومجتمعنا المحلي، لنخلص في النهاية إلى أن النظم العلاجية الشعبية التي اتبعها المجتمع الإماراتي المعاصر كما أكدت على توفير العلاج الطبيعي سعت أيضاً إلى المحافظة على الصحة العامة والخاصة باتباع أنماط صحية ووقائية مدروسة مما يسمح بنشر علاقات إنسانية واعية وسلوكيات صحية إيجابية.
إشكالية الدراسة:
وحول إشكاليات هذه الدراسة فإننا نسعى إلى فهم ماهية الطب الشعبي والطب البديل؟ وكيف تطورت الحياة الطبية والصحية في المجتمع الإماراتي؟ وما أهم مظاهر ومميزات هذه الثقافة الطبية والصحية وكذا طرق التداوي بالأعشاب والممارسات الطبية الشعبية المتوارثة في البيئة الإماراتية؟ وماهي الأمراض الشائعة في المنطقة وكيف يمكن علاجها بالوصفات التقليدية القديمة؟
Role Of Transportation Thein Supporting Sustainable Halal Tourism In Indonesia
Authors: Peristiwo Hadi 
Published: October 2021

The potential for the development of halal tourism in Indonesia is considered very promising and will become a business that many tourism businesses are interested in. This is in line with the increase in halal tourism from year to year. Transportation has an important role in supporting sustainable halal tourism. This journal's literature review will explore the role of transportation in sustainable halal tourism, the concept of transportation mode planning in sustainable halal tourism and discuss transportation challenges and problems for sustainable halal tourism in Indonesia. This journal review literature research method is carried out by searching for published articles on Sage, Elsivier Science and Taylor & Francis with the selected keywords, namely transportation, halal sustainable tourism, and tourism and hospitality. The search was carried out by limiting publications from 2010 - 2020. From the results of the literature search, it can be seen that transportation has an important role for sustainable halal tourism, because the key characteristic of tourists is mobility. Challenges and problems in sustainable halal tourism transportation services in Indonesia in general are still faced with problems of increasing safety, increasing smooth mobility and problems of service accessibility.

Key words : transportation, sustainable halal tourism.
Analysis on the Four Paths of the Party’s Clean Government Culture in the New Era
Authors: Fang Xiao , Wang Anping 
Published: October 2021

The construction of clean government culture is the key link for the Communist Party of China to carry out the work of combating corruption and promoting clean government, and it is also an important step to strengthen the building of a clean and honest party and to win an overwhelming victory in the struggle against corruption. In the new era, promoting the construction of the Party's clean government culture by firming the People' s Position, building up the foundation of faith, improving the Party spirit cultivation of Party members and strengthening the construction of party conduct, which will help to alert people, especially party members and cadres to cultivate integrity and self-discipline, can open up a new and effective path for comprehensive and strict administration of the Party.
A Fantasy Theme Analysis of Chinese Rhetorical Vision on Xinjiang Cotton Incident
Authors: Wu Yanan 
Published: October 2021

At the end of March 2021, some international brands and international organizations boycotted Xinjiang cotton and related products in their commercial activities, which aroused great indignation among people from all walks of life in China, and people had come forward to stand up for Xinjiang as well as Xinjiang cotton. This paper lays emphasis on the response of Chinese people to the Xinjiang cotton incident and commits to analyze what and how the fantasy themes are able to achieve with regards to the creation of rhetorical visions within contexts of symbolic convergence theory.
The Effect of Topical Corticosteroid Time of Application on Fibroblast and Type III Collagen Expression in Oryctolagus cuniculus with Deep Dermal Burn Wound (As an Indicator for the Best Time to Start Topical Corticosteroid Application in Preventing Hypertrophic Scar)
Authors: Lumintang Loelita , Adnyana I Made Suka , Hamid Agus Roy , Sanjaya Hendra , Golden Nyoman , Astawa Putu , Darmajaya Made , Sumadi I Wayan Juli 
Published: October 2021

Background: Hypertrophic scar is an abnormal scar that causes physical deteriorations, psychological problems, and aesthetic issues. An excessive number of fibroblasts and collagen III expressions are histopathology indicators for the hypertrophic scar. The role of topical corticosteroids in suppressing inflammation and hypergranulation had widely demonstrated in previous studies. However, there is no study related to the application of topical corticosteroids as prevention of hypertrophic scars from burn wound found. Hence, this study aimed to examine the evidence of the effects of corticosteroid topical in decreasing the number of fibroblasts and type III collagen expression and the best time to start its application in preventing hypertrophic scars. Methods: This randomized experimental post-test only study involved 54 deep dermal burn wounds on the ventral ear of female Oryctolagus cuniculus that distributed into three groups based on the healing phases. Each group consisted of treatments and controls. Corticosteroid topical application on the first treatment group (inflammatory phase group), the second group (proliferation phase group), and the third group (remodelling phase group) was started on day 3, on day 10, and day 21, respectively. Specimens taken on day 35. Haematoxylin-Eosin and Immunohistochemically staining performed to measure the number of fibroblasts and type III collagen and to observe the epithelization and inflammation process. Results: The number of fibroblasts significantly decreased in the second treatment group (p =0.001) and followed by the first group (p = 0.016), but no significant decrease found in the third group (p = 0.430). The type III collagen decreased significantly in the second treatment group (p = 0.000) and followed by the third group (p = 0.019), but no significant decrease found in the first group. There was no statistically different number of fibroblast and type III collagen discovered between the controls. Complete epithelization found in all groups. Also, no ongoing inflammation found in all groups. Conclusion : Topical corticosteroids on deep dermal burn wound revealed to be effective in reducing the number of fibroblasts and type III collagen with no healing disruption. The proliferation phase found to be the best time to start the application of topical corticosteroids.
Undergraduate Nursing Students' Stress and Fear of Missing Out
Authors: Çevik Aktura Seher , Özden Gürkan , Çıtlık Sarıtaş Seyhan 
Published: October 2021

Background:
This descriptive study analyzed the stress in nursing education and the fear of missing out.

Method:
This study was conducted at a public university in eastern Turkey and included 1,119 undergraduate nursing students. Result: Findings indicated there was no statistically significant relationship between the levels of stress experienced by students during their nursing education and their fears of missing out.

Conclusion:

In light of these findings, recommendations include identifying the factors leading to stress and fear of missing out for undergraduate nursing students and then developing potential strategies to help allay nursing students' stress and fears.

[
J Nurs Educ
. 2021;60(10):559–565.]
Cutting Edge: Lung-Resident T Cells Elicited by SARS-CoV-2 Do Not Mediate Protection against Secondary Infection
Authors: Roberts Lydia M , Jessop Forrest , Wehrly Tara D , Bosio Catharine M 
Published: October 2021

Abstract
Immunity to pulmonary infection typically requires elicitation of lung-resident T cells that subsequently confer protection against secondary infection. The presence of tissue-resident T cells in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent patients is unknown. Using a sublethal mouse model of coronavirus disease 2019, we determined if SARS-CoV-2 infection potentiated Ag-specific pulmonary resident CD4+ and CD8+ T cell responses and if these cells mediated protection against secondary infection. S protein–specific T cells were present in resident and circulating populations. However, M and N protein–specific T cells were detected only in the resident T cell pool. Using an adoptive transfer strategy, we found that T cells from SARS-CoV-2 immune animals did not protect naive mice. These data indicate that resident T cells are elicited by SARS-CoV-2 infection but are not sufficient for protective immunity.
Anticonvulsive evaluation and histopathological survey of thalidomide synthetic analogs on lithium-pilocarpine-induced status epilepticus in rats
Authors: Amanlou Arash , Eslami Faezeh , Shayan Maryam , Mortazavi Pejman , Dehpour Ahmad Reza 
Published: October 2021

Background and purpose:
Status epilepticus is a severe neurological disorder that can be life-threatening. Thalidomide and its analogs have shown promising results to confront pentylenetetrazole-induced seizures. This study aimed to evaluate the potential effects of three synthesized thalidomide derivatives on lithium-pilocarpine-induced status epilepticus.

Experimental approach:
To induce status epilepticus, rats received lithium chloride (127 mg/kg, i.p.) and pilocarpine HCl (60 mg/kg, i.p.) 20 h after lithium chloride injection. Thirty min before pilocarpine HCl administration, rats received hyoscine N-butyl bromide (1 mg/kg, i.p.) and concurrently one of the test compounds (5B, 5C, and 5D), diazepam, thalidomide, or vehicle (4% DMSO) to evaluate their anti-epileptic effects. Epileptic seizures scores were assessed through the Racine scale. Twenty-four h after injection of pilocarpine, brain samples were extracted for further histopathological evaluation.

Findings/Results:
Results revealed that among tested compounds (5B, 5C, and 5D), only compound 5C (1 mg/kg) exhibited excellent anti-epileptic activity comparable to diazepam (10 mg/kg). Compound 5D (100 mg/kg) only demonstrated comparable anti-epileptic activity to thalidomide (1 mg/kg). Compound 5B did not have any anti-epileptic activity even at the dose of 100 mg/kg. The histopathological survey showed that compound 5C has more neuroprotective effects than diazepam and thalidomide in the cortex of the brain. In the cornu ammonis 1 region, thalidomide had higher protective properties and in the cornu ammonis 3 and dentate gyrus areas, diazepam had higher efficacy to prevent necrosis.

Conclusion and implications:
Compound 5C is a good candidate for further studies regarding its potency, compared to thalidomide and diazepam.
Artemether-loaded nanostructured lipid carriers
Authors: Rahnama Vahid , Motazedian Mohammad Hossein , Mohammadi-Samani Soliman , Asgari Qasem , Ghasemiyeh Parisa , Khazaei Meisam 
Published: October 2021

Background and purpose:
Cutaneous leishmaniasis is a global health problem. The discovery of new and highly efficient anti-leishmanial treatments with lower toxicity is globally needed. The current study was carried out to evaluate the anti-leishmanial effects of artemether (ART) and ART-loaded nanostructured lipid carriers (ART-NLCs) against promastigotes and amastigotes of Leishmania major.

Experimental approach:
Solvent diffusion evaporation technique was applied to prepare ART-NLCs. These nanoparticles were characterized using a particle size analyzer (PSA), transmission electron microscopy (TEM), and dynamic light scattering (DLS). The antiparasitic activity on amastigote was assessed in J774 cell culture. The drug cytotoxicity on promastigote and macrophage was assessed using the MTT technique after 24 and 48 h and compared with NLCs, ART, and amphotericin B, as the control agents. The selectivity index was calculated for the agents.

Findings/Results:
The DLS and PSA techniques confirmed that ART-NLCs were homogenous in size with an average diameter of 101 ± 2.0 nm and span index of 0.9. The ART-NLCs significantly heighten the anti-leishmanial activity of ART (P < 0.001). The IC50 values of ART and ART-NLCs on promastigotes after 24 and 48 h were 76.08, 36.71 and 35.14, 14.81 μg/mL, respectively while they were calculated 53.97, 25.43 and 20.13, 11.92 for amastigotes. Also, ART-NLCs had the lowest cytotoxicity against macrophages. Furthermore, among the agents tested, ART-NLCs had the highest selectivity index.

Conclusion and implications:
ART-NLCs had lower cytotoxic effects than ART and amphotericin B, also its selectivity index was significantly higher. Based on the findings of the study, this formulation could be a promising candidate for further research into leishmaniasis treatment.
Attenuating effects of allantoin on oxidative stress in a mouse model of nonalcoholic steatohepatitis
Authors: Hamidi-zad Zeinab , Moslehi Azam , Rastegarpanah Maryam 
Published: October 2021

Background and purpose:
Nonalcoholic steatohepatitis (NASH) is considered a common and serious liver disease, which develops into cirrhosis, fibrosis, and even hepatocellular carcinoma. Oxidative stress is identified as an important factor in the induction and promotion of NASH. Allantoin is a natural and safe compound and has notable effects on lipid metabolism, inflammation, and oxidative stress. Therefore, this study was aimed to assess the role of allantoin on the oxidative stress and SIRT1/Nrf2 pathway in a mouse model of NASH.

Experimental approach:
C57/BL6 male mice received saline and allantoin (saline as the control and allantoin as the positive control groups). NASH was induced by a methionine-choline deficient diet (MCD). In the NASH-allantoin (NASH-Alla) group, allantoin was injected for 4 weeks in the mice feeding on an MCD diet. Afterward, histopathological, serum, oxidative stress, and western blot evaluations were performed.

Findings/Results:
We found NASH provided hepatic lipid accumulation and inflammation. Superoxide dismutase (SOD) and glutathione (GSH) levels decreased, lipid peroxidation increased, and the expression of SIRT1 and Nrf2 downregulated. However, allantoin-treatment decreased serum cholesterol, ALT, and AST. Liver steatosis and inflammation were improved. Protein expression of SIRT1 and Nrf2 were upregulated and SOD, CAT, and GSH levels increased and lipid peroxidation decreased.

Conclusion and implications:
It seems that the antioxidant effects of allantoin might have resulted from the activation of SIRT1/Nrf2 pathway and increase of cellular antioxidant power.
Case Report: Home-based Management of Severe COVID-19 with Low-dose Tofacitinib
Authors: Sharma Ashish , Ali Mohammad 
Published: October 2021

ABSTRACT.
Human lives and nations’ economies have been adversely affected worldwide by the COVID-19 pandemic. The hyperinflammatory state associated with the disease may be related to mortality. Systemic glucocorticoid is the first-line therapy for cytokine storm. Various immunomodulatory drugs such as tocilizumab and baricitinib have been used in those not responding to glucocorticoid monotherapy. Amid the peak crisis of COVID-19 in India, there was an extreme paucity of medications, oxygen, and hospital beds. We describe three patients with COVID-19 who received low-dose tofacitinib (an oral Janus kinase inhibitor) in addition to moderate-dose glucocorticoid. These patients were treated at their homes, as the hospitals were short of beds. Rapid reduction in hypoxemia along with gradual resolution of other signs of the disease were observed. The results are reassuring regarding the feasibility of managing of severe COVID-19 outside the hospital setting when healthcare resources are overwhelmed by pandemic-related caseload.
ORGANIZATIONAL CULTURE AND STRUCTURE AS DETERMINANTS OF SERVICE DELIVERY IN THE COUNTY GOVERNMENT OF KITUI
Authors: Mbiti Japheth , Misango Sedina 
Published: October 2021

Purpose: In early years of the 21st Century, Kenya started a journey of developing a new constitution which established the devolved system of government to improve on governance gaps. Since the introduction of devolution, County governments have introduced new organizational culture and structures which assist in service delivery. Consequent to this development, the objective of the study was to determine the influence of organizational culture and structure on service delivery in the County Government of Kitui and specific objectives of the study were to establish the influence of organizational culture and organizational structure on service delivery in the County Government of Kitui.
Methodology: The study adopted a descriptive research design and made use of a sample size by use of both stratified random and simple random sampling methods to establish the study sample. For effective data collection, the study was based on primary data which was both qualitative and quantitative. The data was collected through questionnaires and analyzed using Statistical Package for Social Science (SPSS) version 22.The analysis involved descriptive and inferential statistics. Data was presented in form of frequency tables for easy interpretation. Regression analysis was employed to establish the relationship between the variables.
Results: The study established that organizational structure and organizational culture have significant effect on the Kitui county residence service delivery. The study concludes that the County government has implemented the constitutional structure and adopted a beneficial culture which ensures good planning procedures for effective service delivery.
Unique contribution to theory, practice and policy: The study recommends that the County management should embrace good governance and promote the available cultural practices and that the structure be made shorter to empower junior officers with more authority and responsibilities.
Educación y Formación Técnica Profesional costarricense ante el cambio demográfico y productivo 2020-2030
Authors: Láscarez Smith Daniel , Vargas Méndez Monserrat , Baumann Fabienne-Agnes 
Published: October 2021

El presente artículo analiza la forma en que el cambio demográfico y productivo podrían afectar las acciones institucionales de la Educación y Formación Técnica Profesional (EFTP) en Costa Rica en los próximos 10 años, principalmente, en cuanto a su capacidad de anticipar las demandas de cualificación y estrategias en el largo plazo. Metodológicamente, se realizó una proyección y descripción estadística del comportamiento del mercado laboral y demográfico a nivel nacional. También se revisó documentos e investigaciones institucionales sobre el tema. Una de las conclusiones más relevantes es que la variable demográfica afecta a la EFTP debido a la reducción futura de mano de obra, sin embargo no existen estrategias institucionales claras para hacer frente a la reconversión productiva, aumento de la productividad y detección de necesidades especificas de la población joven y del mercado laboral. De tal manera, se proponen acciones innovadoras y puntuales que podrían mejorar la gestión de las instituciones frente a las problemáticas identificadas.