bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malaysian Enhanced Movement Control Order (EMCO): a unique and impactful approach to combating pandemic COVID-19
Authors: Hassan Mohd Rohaizat , Subahir Mohd Nizam , Rosli Linayanti , Che Mat Din Shaharom Nor Azian , Ismail Nor Zaher , Bahuri Nor Hana Ahmad , Ibrahim Farha , Othman Naffisah , Abas Zulfikri , Mohammed Nawi Azmawati 
Published: June 2021

PurposeThe paper highlights the process-handling during the Enhanced Movement Control Order (EMCO) in combating pandemic COVID-19 in Malaysia.Design/methodology/approachMalaysia first issued an EMCO following a cluster that involved a religious gathering. The EMCO was issued to lockdown the area, undertake screening, treat positive cases and quarantine their close contacts. Active case detection and mass sampling were the main activities involving the population in both zones.FindingsOne hundred ninety-three confirmed COVID-19 cases were identified from the total population of 2,599. Of these cases, 99.5% were Malaysians, 31.7% were aged >60 years and all four deaths (Case Fatality Rate, 2.1%) were elderly people with comorbidities. One hundred and one cases (52.3%) were asymptomatic, of which 77 (77%) were detected during mass sampling. The risk factors contributing to the outbreak were contacts that had attended the religious gathering, regular mosque congregants, wedding ceremony attendees and close household contacts. Malaysia implemented an effective measure in the form of the EMCO to contain the COVID-19 outbreak, where the last cases were reported 16 days before the EMCO was lifted.Originality/valueThe residents’ compliance and inter-agency cooperation were essential elements to the success of the EMCO. A targeted approach using an EMCO should be implemented in a future pandemic.
Agile learning strategies to compete in an uncertain business environment
Authors: Armanious Michael , Padgett Jared D. 
Published: June 2021

Purpose
The purpose of this study was to explore what agile learning strategies businesses need to develop agile core competencies to respond to the uncertainty of the rapidly changing business environment and sustain their competitive advantage. Technology advances and unexpected crises have created an ever-changing environment in which traditional static corporate training methods have failed to continuously provide employees with the ability to listen to and interpret the rapid changes and respond accordingly.

Design/methodology/approach
This qualitative exploratory multi-case study was useful to explore what agile learning strategies businesses need to develop agile core competencies to sustain their competitive advantage. Snowball sampling enabled the discovery of 15 participants who represented 10 different industries. Participants represented both management and non-management roles. Data were collected from multiple sources such as interviews, observations, researcher notes and document reviews. A thematic analysis model was used to analyze the collected data.

Findings
The findings substantiated that organizations are operating in a fast-changing environment where agile learning strategies are vital to surviving. The data also showed that agile learning strategies must include individual learning paths to continuously develop employees’ agile skills to build their organizations’ agile core competencies.

Originality/value
This study underlined the importance of adopting agile learning strategies to help employees listen and accurately interpret their organizations’ external environments to enable quick responses to changes. Without agile learning strategies, organizational agile core competencies and competitive advantage will progressively decline.
“Digesting the abundance of idol matter” key factors in personal information management experiences of selected social science faculty
Authors: Nwagwu Williams 
Published: June 2021

Purpose
The purpose of this paper is to examine the personal information management (PIM) behaviours of social science faculty in Africa. The study examined the experiences and encounters of selected social scientists in Africa in organising and finding and re-finding of the information they previously created or stored. More specifically, the study sought to examine how faculty keep and refind information, the files and folders in which they store the information. Also, the study examined the nature and characteristics of faculty information spaces with particular respect to electronic documents including emails and paper documents.

Design/methodology/approach
Sample survey research design and a mixed methods approach consisting of qualitative and quantitative were used. Data was collected using a discursive technique, an interview schedule and a questionnaire. Data analysis was conducted using factorial analysis of mixed data design, guided by a combination of category and codes identification using NVivo and Statistical Package for the Social Sciences (SPSS) 17. Principal component analysis (PCA) of factor analysis was executed to identify key components.

Findings
Eleven issues, namely, time, infrastructure, importance of the information, folder/file management, document characteristics and organisational context played significant roles in the PIM behaviours of the respondents. Others were importance of the information, document overload, memory, workload and computer literacy. PCA extracted four major components, namely, document overload, time, computer literacy and importance of the information.

Research limitations/implications
An expansion in the number of faculty involved in this study would probably yield a more reliable outcome. Extending the study to cover Africa would also yield a more applicable result.

Practical implications
The key PIM issues identified in this study, namely, document overload, time, computer literacy and importance of the information should constitute the focus of continuous information literacy education aimed at improving PIM social scientists’ faculty in Africa.

Social implications
Improved PIM of social science faculty will result to improved research productivity and good health.

Originality/value
PIM of social scientists has not been examined in the literature, and yet it is crucial for further understanding their learning and information behaviours, and improving their productivity. The design and administration of a questionnaire constructed based on codes extracted from qualitative and discursive sessions to the same respondents from whom the qualitative data was collected makes the findings very strong. A further deployment of factorial analysis of mixed data design to handle qualitative data makes the contribution of the study very significant.
Alteration in phenological parameters, above‐ and belowground biomass, nutrient contents, and their pools with phenological stages of Salicornia brachiata Roxb
Authors: Rathore Aditya P. , Chaudhary Doongar R. , Jha Bhavanath 
Published: June 2021

AbstractThe present study aimed to examine the alteration in phenological parameters, above‐ and belowground biomass, nutrient contents, and nutrient pools at different phenological stages (seedling, vegetative, flowering, senescence start, senescence complete, and dry stage) of Salicornia brachiata Roxb. According to our results, plant height was significantly higher at the senescence start, senescence complete, and dry stages; however, the water content was significantly higher at the seedling stage. Furthermore, the above‐ and belowground biomass of S. brachiata was recorded in the range between 0.57–533.69 g m−2 and 0.12–15.91 g m−2, respectively while the highest above‐ and belowground biomass was documented at the senescence start stage. The nutrient contents of C, N, P, Na+, K+, Ca2+, Mg2+, and Cl− in above‐ and belowground biomass were estimated and we found significant spatial and stage‐wise variations. The aboveground pools of carbon (66.52 g m−2), phosphorus (0.40 g m−2), sodium (39.81 g m−2), potassium (3.76 g m−2), magnesium (2.85 g m−2), and chloride (64.66 g m−2) were higher at the senescence start stage. The averaged bioaccumulation and translocation factors for Na+ were 8.91 and 3.66, respectively which indicated the phytoremediation capacity of S. brachiata of salt‐affected soils. The results of the present study witnessed significant changes in phenological parameters, above‐ and belowground biomass, nutrient contents, and their pools with the phenological stages of S. brachiata. Furthermore, present findings suggest that S. brachiata may be utilized for the coastal development program of India and rehabilitation of salt‐affected soils.
Anticancer activity of protein fractions from chia (Salvia hispanica L.)
Authors: Quintal‐Bojórquez Nidia del Carmen , Carrillo‐Cocom Leydi Maribel , Hernández‐Álvarez Alan Javier , Segura‐Campos Maira Rubí 
Published: June 2021

AbstractSalvia hispanica demonstrated to be a source of protein fractions with anticancer activity. The effect of the protein fractions <1, 1–3, and 3–5 kDa, obtained by ultrafiltration of the S. hispanica hydrolysate, was evaluated on the cellular viability of four cancer cell lines (MCF‐7, Caco2, PC‐3, and HepG2) and on human fibroblasts (hFB) at different concentrations (0.25, 0.5, 0.75, and 1 mg/ml). The protein fractions did not show cytotoxic effects on hFB. The protein fraction <1 kDa at 1 mg/ml showed the highest statistical effect on the cellular viability of all evaluated cancer lines; thus, its amino acid sequence was analyzed. From the multicriteria decision analysis of the peptide sequences obtained by mass spectrometry, the peptide KLKKNL with potential anticancer activity was selected. In conclusion, protein fractions could represent a therapeutic option for cancer treatment. However, further investigations are necessary to establish conclusive arguments.Practical ApplicationThe work of this article is based on the background of the increasing potential of peptides for the treatment of chronic diseases. The results of this study present peptides of low molecular weight, obtained from chia seeds, as a potential adjuvant option for cancer treatment.
Lung squamous cell carcinoma with severe hypomagnesemia due to cisplatin plus gemcitabine in combination with necitumumab therapy: A case report
Authors: Nakao Akira , Inoue Hiroyuki , Osaki Yusuke , Hirano Ryosuke , Harada Taishi , Aoyama Takashi , Igata Fumiyasu , Fujita Masaki 
Published: June 2021

AbstractA 72‐year‐old man, diagnosed with advanced lung squamous cell carcinoma, was administered of cisplatin plus gemcitabine with necitumumab, a human monoclonal antibody that binds to the epidermal growth factor receptor (EGFR), as a sixth‐line treatment. Tumor shrinkage was observed, but asymptomatic grade 4 hypomagnesemia occurred on day 8 of the second cycle. He received magnesium replenishment and hypomagnesemia recovered on day 40, but tumor progression was observed during the period of magnesium correction. Hypomagnesemia is known as a major adverse event of treatment with anti‐EGFR antibodies, but there have been no case reports of severe hypomagnesemia or its clinical course.
Oocyte aging is controlled by mitogen‐activated protein kinase signaling
Authors: Achache Hanna , Falk Roni , Lerner Noam , Beatus Tsevi , Tzur Yonatan B. 
Published: June 2021

AbstractOogenesis is one of the first processes to fail during aging. In women, most oocytes cannot successfully complete meiotic divisions already during the fourth decade of life. Studies of the nematode Caenorhabditis elegans have uncovered conserved genetic pathways that control lifespan, but our knowledge regarding reproductive aging in worms and humans is limited. Specifically, little is known about germline internal signals that dictate the oogonial biological clock. Here, we report a thorough characterization of the changes in the worm germline during aging. We found that shortly after ovulation halts, germline proliferation declines, while apoptosis continues, leading to a gradual reduction in germ cell numbers. In late aging stages, we observed that meiotic progression is disturbed and crossover designation and DNA double‐strand break repair decrease. In addition, we detected a decline in the quality of mature oocytes during aging, as reflected by decreasing size and elongation of interhomolog distance, a phenotype also observed in human oocytes. Many of these altered processes were previously attributed to MAPK signaling variations in young worms. In support of this, we observed changes in activation dynamics of MPK‐1 during aging. We therefore tested the hypothesis that MAPK controls oocyte quality in aged worms using both genetic and pharmacological tools. We found that in mutants with high levels of activated MPK‐1, oocyte quality deteriorates more rapidly than in wild‐type worms, whereas reduction of MPK‐1 levels enhances quality. Thus, our data suggest that MAPK signaling controls germline aging and could be used to attenuate the rate of oogenesis quality decline.
Unraveling preferences for religious ties in food transactions: A consumer perspective
Authors: D'Haene Eline , Tur Cardona Juan , Speelman Stijn , Schoors Koen , D'Haese Marijke 
Published: June 2021

AbstractFood choices are key in communicating religious identities and marking religious boundaries. Whereas the literature has focused on religion's impact on food habits, the effect of religion on food market exchanges remains largely unexplored. Using the Ethiopian milk market as a case study, we conduct a series of innovative experimental choice tasks with urban dairy consumers to elicit their preferences for milk seller characteristics. In the choice tasks, milk seller profiles are constructed using five relevant attributes: milk price, distance to the selling point, seller type, seller gender, and seller religious affiliation. We observe consumer preferences for lower milk prices, shorter distances, and dairy farmers over milk shops. When accounting for attribute non‐attendance, we find that consumers who take religion into account prefer co‐religious sellers, and that consumers who take gender into account generally prefer female sellers. Our results enrich our understanding of the role of religion in purchase behavior and market segmentation.
Relapse risk factors for patients with comorbid affective disorders and substance abuse disorders from an intensive treatment unit
Authors: Wang Mike , Pinilla Gabriel , Leung Curtis , Peddada Apoorva , Yu Eileen , Akmal Sarfraz , Cha Youngjae , Dyson Laketa , Kumar Anupama , Kaplin Adam 
Published: June 2021

AbstractBackground and ObjectivesThe prevalence of substance use disorders (SUD), particularly involving opiates and benzodiazepines, has increased to the detriment of public health and the economy. Here, we evaluate relapse factors among the high‐risk demographic of patients with SUD and comorbid affective disorders.MethodsA retrospective chart review of 76 patients discharged after detoxification and simultaneous psychiatric care for concomitant affective disorders and SUDs. Relapse was assessed by two independent evaluators via postdischarge chart review, which included state‐wide healthcare utilization, by patient, through healthcare information exchange systems. A Cox Hazards analysis was performed to characterize relapse risk factors.ResultsBenzodiazepine use, admission through the emergency department (ED) rather than direct admission, frequent ED use in the preceding year, and history of prior attendance at multiple detoxification programs were risk factors for shortened time‐to‐relapse. Polysubstance use and intravenous drug use prolonged time to relapse.Discussion and ConclusionsNotable findings include the significant relapse risk associated with benzodiazepine abuse and frequent prior ED utilization. These risk factors could reflect a number of underlying mediators for relapse, including anxiety, disease burden, and malingering. Additionally, this study recapitulates the observation in other patient populations that the majority of health resource utilization is attributed to a small population of patients.Scientific SignificanceThis study is the first to identify relapse predictors among dual‐diagnosis affective disorder and SUD patients in survival analysis, and replicates the alarming and largely unknown effect that benzodiazepines have on increasing relapse risk.
Placental characteristics in different types of selective fetal growth restriction in monochorionic diamniotic twins
Authors: Wang Xueju , Li Luyao , Yuan Pengbo , Zhao Yangyu , Wei Yuan 
Published: June 2021

AbstractIntroductionThis study aimed to explore the differences in placental characteristics among three types of selective fetal growth restriction (sFGR) in monochorionic diamniotic twin pregnancies.Material and methodsA total of 123 placentas with sFGR between April 2013 and October 2019 were retrospectively analyzed after dye injection. Placental characteristics were compared among the three types.ResultsThe gestational age at diagnosis and delivery was less in sFGR II and III than in sFGR I (22.9 [21.7–33.6], 23.3 [20.0–26.1] and 25.7 [19.0–35.0] weeks, p < 0.001; 32.3 [31.6–35.1], 34.1 [29.9–34.7] and 35.5 [34.0–37.0] weeks, p < 0.001). The birthweight discordance ratio was less in sFGR I than in sFGR II (0.28 [0.14–0.43] and 0.30 [0.23–0.37], p < 0.001). The prevalence of a thick artery–artery anastomosis was higher in sFGR III than in sFGR I or II (81.8%, 44.9% and 48.6%, p = 0.010). The placental territory discordance ratio was higher in sFGR II and III than in sFGR I (0.60 [0.17–0.88], 0.60 [0.01–0.80] and 0.50 [0.01–0.71], p = 0.001).ConclusionsCompared with sFGR I, the earlier onset time of sFGR II and III might be due to their higher placental territory discordance. The prevalence of thick artery–artery anastomoses was expected to be higher in sFGR III than in sFGR I or II.
Test‐dose pharmacokinetics guided melphalan dose adjustment in reduced intensity conditioning allogeneic transplant for non‐malignant disorders
Authors: Chandra Sharat , Mizuno Kana , Zhao Junfang , Davies Stella M. , Marsh Rebecca A. , Fukuda Tsuyoshi , Setchell Kenneth D. R. , Vinks Alexander A. , Mehta Parinda A. 
Published: June 2021

AimsWe studied melphalan pharmacokinetics (PK) and feasibility of melphalan full‐dose adjustment based on test‐dose PK in children and young adults with non‐malignant disorders (NMD) undergoing allogeneic hematopoietic cell transplantation (HCT) using reduced intensity conditioning (RIC) containing alemtuzumab, fludarabine and melphalan.MethodsPatients received test‐dose melphalan (10% of planned full‐dose) prior to conditioning. Blood samples for PK were obtained around test and full‐dose melphalan (140 mg/m2 or 4.7 mg/kg in patients <10 kg). Melphalan concentration was measured by liquid chromatography electrospray ionization tandem mass‐spectrometry assay and data were analysed using a population‐PK model and Bayesian estimation. Test and full‐dose melphalan clearance estimates were evaluated by pairwise Wilcoxon test and Bland–Altman plot.ResultsTwenty‐four patients undergoing 25 transplants were included in the final analysis. Patients received standard full‐dose melphalan in 17 transplants, with median area under the concentration–time curve (AUC) of 5.5 mg*h/L (range, 3.0–9.5 mg*h/L). Patients received test‐dose melphalan in 23 transplants with a test‐dose PK predicted full‐dose AUC range of 2.9–16.8 mg*h/L. In seven transplants where patients had baseline organ impairment, test‐dose PK predicted higher exposure for standard full‐dose (median AUC 13.8 mg*h/L). Melphalan full‐dose was adjusted in these patients, with achievement of desired target AUC (3.6–5.4 mg*h/L) and no excess toxicity. Mean ratio of test‐dose clearance to full‐dose clearance was 1.03. Twenty of 22 patients (91%) were within the 95% confidence intervals of the clearance ratio.ConclusionMelphalan test‐dose PK reliably predicts full‐dose PK and allows for accurate adjustment of full‐dose melphalan in RIC‐HCT for NMD. This approach can avoid excess toxicity from increased systemic exposure, especially in patients with organ impairment.
Risk of recurrent venous thromboembolism in patients with autoimmune diseases: data from the Registro Informatizado de Enfermedad TromboEmbólica (RIETE) registry
Authors: Borjas Howard Jaime , Ruiz‐Sada Pablo , de Leeuw Karina , López‐Jiménez Luciano , Font Carme , Marchena Pablo Javier , Madridano Olga , Debourdeau Philippe , Meijer Karina , Monreal Manuel ,   the Registro Informatizado de Enfermedad TromboEmbólica (RIETE) Investigators
Published: June 2021

SummaryAutoimmune disease is a risk factor for first incident venous thromboembolism (VTE). However, data on the risk of recurrent VTE in people with autoimmune disease is sparse. We explored the risk of recurrent VTE using the RIETE registry, comparing people with autoimmune disease (n = 1305) to those without (n = 50608). Overall rates were 6.5 and 5.1 recurrent VTE/100 years for patients with autoimmune disease vs controls, respectively. After adjustment for sex and unprovoked/provoked VTE yielded an adjusted hazard ratio of 1.29 (95%CI 1.03‐1.62). The analysis was limited by short median follow up time (161 days overall), precluding definitive conclusions on recurrent VTE risks.
Using counterfactual thinking theory to change alcohol protective behavioural strategy use intentions
Authors: De Leon Ardhys N. , Dvorak Robert D. , Smallman Rachel , Arthur Kianna , Piercey Cianna 
Published: June 2021

ObjectivesDespite numerous drinking interventions, alcohol use among college students remains a significant problem. Typically activated after negative events, counterfactual thinking is a cognitive process that contrasts reality with an imagined better alternative. As a result, counterfactual thinking highlights potential causal links between problematic behaviours and negative outcomes, which can strengthen intentions to change behaviour. Recent research has found that modifying behavioural intentions to engage in protective behavioural strategies (PBS) has led to increased PBS use and reduced alcohol outcomes. The current study evaluated counterfactual thinking as a way to increase PBS use intentions.DesignIntervention US study with college student drinkers.MethodsA sample of college students (n = 466) completed a web‐based assessment of demographics, drinking, alcohol consequences, and PBS use. Those who endorsed an adverse drinking event were randomly assigned to an intervention condition (Control, Negative event only, Negative event with description, or Negative event with counterfactual). Following the intervention, participants reported intentions to engage in each PBS subtype over the next week.ResultsRelative to control, the counterfactual condition resulted in greater PBS use intentions across all subtypes. Neither the negative event only nor the negative event with description resulted in higher PBS use intentions, relative to control. Importantly, the control group did not report whether they experienced a negative event; thus, we cannot definitively determine the effect this may have on the data.ConclusionsThis study provides a new theory‐driven avenue for alcohol use interventions utilizing counterfactual thinking to enhance safe drinking intentions.