bluuebunny/crossref_metadata_2025_split huggingface dataset:
Costae rib resection and bypass right caroticosubclavian artery for thoracic outlet syndrome and follow up after 6 months: a rare case
Authors: Septiandi Yohannes , Winarno Dhihintia Jiwangga Suta , Rizki Mohamad 
Published: January 2025

Link of Video abstract: https://youtu.be/6Ii8V3P1_Ys

Introduction: The condition known as TOS is brought on by pressure on the nerve plexuses and blood vessels in the upper thoracic aperture region. Congenital or acquired abnormalities may be cause for this. The symptoms of TOS, which are caused by compression of the brachial plexus or subclavian artery or vein. Depending on the arteries, veins, nerves, or anatomical anomalies that are impacted, different symptoms may manifest. This study aims to increase our familiarity with the symptoms of TOS and follow-up postoperative outcomes after 6 months.
Case Presentation: A 32-year-old man was referred to a tertiary hospital in Surabaya from a secondary hospital in Surabaya. Patients complain of right arm pain about 1 month before. The CTA evaluation right subclavian artery stenosis, right radial artery stenosis, right posterior interosseus artery stenosis. The patient underwent elective surgery for costae rib resection and bypass right caroticosubclavian artery. Evaluation postoperative after surgery, the patient was treated in the low care room with early extubated conditions. Extubation is done immediately in OT. Three days after extubation the patient went home. 6 days postoperatively patient controls into the outpatient department of cardiothoracic surgery. Progress was followed up to 6 months and yielded a good result.
Conclusion: Surgical intervention is a possibility for treating the symptoms that patients describe suffering. Decompress the thoracic outlet by removing the first rib, either alone or in conjunction with additional vascular reconstructive surgeries.
Combined ipsilesional excitation and contralesional inhibition of Repetitive Transcranial Magnetic Stimulation (rTMS) as a motor rehabilitation in ischemic stroke patient: a case report
Authors: Tammasse Jumraini , Gunawan Anthony 
Published: January 2025

Link of Video Abstract: https://youtu.be/Unt1HueFSEE

Background: Stroke is one of the major health problems in the world, with high mortality and disability rates. Transcranial Magnetic Stimulation (TMS) is a non-invasive and safe method of stimulating neurons in the brain. Various studies have used rTMS as an adjunctive modality to enhance motor restoration after stroke.
Case Presentation: A 35-year-old man was brought to the hospital with sudden weakness in the right side of his body since 9 days ago. On neurological examination, there was paresis of right cranial nerves VII and XII and left internuclear ophthalmoplegia. His motor strength in the right extremities was 1 for the deltoid and iliopsoas and 0 for other muscles. He received combined ipsilesional excitation in C3, left dorsolateral prefrontal cortex (DLPFC), and contralesional inhibition in C4. His proximal motor strength and diplopia slightly improved after treatment.
Conclusion: Combined ipsilesional excitation in the ipsilesional motor cortex and DLPFC and inhibition in the contralesional motor cortex can improve motor strength and diplopia in ischemic stroke patients.
Comparison of the immunomodulatory potential of tuber extracts Purple Sweet Potato (Ipomoea batatas L) and Sembung leaf extract (Blumea balsamifera L) in an oxidative stress rat model induced by maximum physical activity
Authors: Yasa I Wayan Putu Sutirta , Subawa Anak Agung Ngurah , Jawi I Made 
Published: January 2025

Link of Video Abstract: https://youtu.be/PAliBnEh_Ac

Background: Heavy physical activity causes changes in the distribution of leukocyte subpopulations due to oxidative stress. Research shows decreased CD4 due to heavy physical activity and increased pro-inflammatory interleukins. This study aimed to compare the benefits of exogenous antioxidants from two medicinal plant extracts, purple sweet potato tuber extract and sembung leaf extract, in the maximal swimming rat model.
Methods: The research subjects were 27 adult Wistar rats divided into 3 groups using a randomized posttest-only control group design. The mice were divided into 3 groups, namely the control group (9 animals), which was not given purple sweet potato tuber extract or sembung leaf extract. Treatment group 1 (9 animals) was given 200 mg/day of purple sweet potato tuber extract for 2 weeks. Treatment group 2 (9 animals) was given sembung leaf extract at 4 mg/day for 2 weeks. After 2 weeks of administering the extract, all mice swam for 30 minutes (until they nearly drowned). After swimming, blood was examined for TNF-α, CD4, hematopoietic stem cells, and MDA. The data obtained was analyzed using the ANOVA test to see differences between groups.
Results: The results showed that CD4 cells for the group given sembung leaf extract were higher but not significant (p>0.05). HSC (Hematopoietic Stem Cell) cells were higher than the control group (p<0.05) in both treatment groups. MDA and TNFα levels were highest in the control group compared to the treatment group (p<0.05) and did not differ between the two treatment groups (p>0.05).
Conclusion: The conclusion of the research was that giving purple sweet potato tuber extract and sembung leaf extract both caused higher HSC and lower MDA and TNFα, so both test ingredients were immunostimulators, antioxidants, and anti-inflammatory.
Secretome derived from umbilical-cord mesenchymal stem cell enhances the effectiveness of autogenous bone graft in mandibula: a study in rabbit model
Authors: Arista Timotius Hansen , Saputro Iswinarno Doso , Hutagalung Magda Rosalina 
Published: January 2025

Introduction: To the best of our knowledge, research has primarily focused on investigating secretome from bone marrow mesenchymal stem cells (BM-MSCs) for autogenous bone graft; umbilical-cord mesenchymal stem cell (UC-MSCs) secretome remains unexplored. Herein, the aim of the study was to assess the effect of UC-MSCs secretome injection in autogenous bone grafts in rabbit models.
Methods: An experimental study using post-test-only control group design was conducted at Biochemistry Laboratory, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia from August 2023 to January 2024 on six male New Zealand rabbits (Oryctolagus cuniculus). Each rabbit underwent autogenous bone graft on the left and right mandibula. The right mandibula received UC-MSCs secretome injection, serving as an intervention group, while the left mandibula served as control group. UC-MSCs secretome was percutaneously injected into the intervention group every 3 days for 21 days. The following parameters were evaluated: number of osteoblast cells and collagen density.
Results: The intervention group exhibited a statistically significant difference in the number of osteoblast cells (p<0.001), with intervention group showing higher mean values (mean±SD=53.0±9.80) than control group (mean±SD=20.5±8.66). Similarly, for collagen density, a statistical difference was obtained in the intervention group (p=0.002), with the intervention group displaying higher mean values (mean=9.5) than control group (mean=3.5).
Conclusion: UC-MSCs secretome demonstrates significant osteogenic potential and safe application, making it a potential recommendation for bone defect repair. Percutaneous injections of UC-MSCs secretome into autogenous bone grafts every 3 days for 21 days enhance bone healing, indicated by higher osteoblast cell production and collagen density compared to standard of care.
Plantar pressure and level of risk stratification for foot ulcers in type II diabetes mellitus patients
Authors: Primalia Tirandan Menoer Elliza , Pawana I Putu Alit , Utami Ditaruni Asrina , Utomo Budi 
Published: January 2025

Link of Video Abstract: https://youtu.be/Cb5Q1E2lIME

Background: One of the complications of diabetes mellitus is diabetic foot, both with and without ulcers. The International Working Group on the Diabetic Foot (IWGDF) in 2019 established risk stratification of foot ulcers for diabetes mellitus patients based on clinical appearance. Quantitative measurements, such as measuring plantar pressure distribution to assess ulcer risk, are also recommended. This study aims to prove the relationship between plantar pressure and the level of risk stratification of ulcers on the feet of patients with type 2 diabetes mellitus.
Methods: This study is an analytical observational study with a cross-sectional design. The subjects were 41 type 2 diabetes mellitus patients aged 18-59 years without active foot ulcers and a history of amputation. All subjects underwent an assessment of the level of ulcer risk stratification based on IWGDF criteria and received plantar pressure distribution measurements in one visit using an in-shoe measurement system (Pedar-X).
Results: The peak pressure, maximum force, and contact area values of the right and left foot did not have significant differences for each level of risk stratification, except for the peak pressure forefoot of the right foot (p = 0.01 and r = -0.39), maximum force all foot of the right foot (p = 0.03 and r = -0.34), and contact area toes of the right foot (p = 0.04 and r = -0.31), as well as the contact area of the toes and big toes of the left foot (p = 0.01 and r = -0. 39; p = 0.28 and r = -0.32). The level of foot ulcer risk stratification has a significant correlation with HbA1C (p=0.02).
Conclusions: There was no significant correlation of peak pressure, maximum force, and contact area values of the right and left feet, except for peak pressure of the forefoot of the right foot, maximum force of all feet of the right foot, contact area toes of the right foot, contact area toes and big toes of the left foot. A significant correlation was found between HbA1C and the level of foot ulcer risk stratification.
Comparison of self-control and sociability capability of medical students: A multi-year study in Bali, Indonesia
Authors: Manuaba Ida Bagus Amertha Putra , Made Violin Weda Yani  , I Putu Gede Septiawan Saputra  , Ida Ayu Widya Anjani  , Gede Setula Narayana  , I Gede Putu Supadmanaba  , I Gusti Ayu Sri Darmayani  
Published: January 2025

Introduction: Emotional intelligence (EI) is often defined as the ability to perceive, express, understand, and manage emotions and consists of several components. The ability to identify and control one's emotions, including self-control and sociability is well-known as the component of EI. Self-control ability can be used as a predictor of symptoms arising from mental instability, ranging from anxiety to depression, among medical students. The higher self-control can benefit medical students due to its positive correlation with academic achievement and clinical skills. This study aims to explore the association between self control with sociability among medical undergraduates.
Method: This cross-sectional study was conducted in the Faculty of Medicine, Udayana University, from August until October 2023. It compared the self-control and sociability capability of first, second, third, and fourth-year medical students at Udayana University. The data was collected using the Trait Emotional Intelligence Questionnaire-Short Form (TEIQue-SF). Data analysis was carried out using SPSS ver. 25.
Result: This research collected 312 samples of 1st – 4th year medical students. The self-control dimension showed a fluctuation trend of self-control during medical student, where the highest was observed in the 3rd year (26,83±4,06) and then slightly decrease in 4th year (25,79±3,90). The Same result also observed regarding sociability skill, where there was an uptrend from the baseline 20,50±3,32 in 1st year and 21,12±3,65 in 4th year medical student. Still, it was also no significant differences (p>0.05). Post-hoc analysis of the overall level of emotional intelligence as assessed by the self-control and sociability dimension showed no significant association with different grades (p<0.005).
Conclusion: Self-control and sociability dimension showed that there was no significant association.
Comparison of one-stage and two-stage surgery on quality of life and recurrence rate of stage III left colon cancer patients at Dr. Soetomo General Hospital, Surabaya
Authors: Setyaningrum Aisyah Dewi , Danardono Edwin , Wibowo Marjono Dwi 
Published: January 2025

Introduction: Colorectal cancer is the most common malignancy of the gastrointestinal tract and ranks third in cancer incidence. The primary treatment for colorectal cancer is surgery. One-stage surgery is usually done only by resection. Two-stage surgery is done with decompression with a stoma, then planned resection of the tumor at the second stage. This research aims to compare one-stage and two-stage surgery on the quality of life and recurrence rate of colorectal cancer patients.
Methods: This research is an observational retrospective cohort study of stage III colorectal cancer patients who experienced acute abdomen and underwent surgery at Dr. Soetomo General Hospital, Surabaya, from January 2017 to May 2022. The total sample is 40 patients; 20 patients underwent one-stage surgery, and 20 patients had two-stage surgery.
Results: Stage III colorectal cancer patients who underwent two-stage surgery had an average quality of life better than those single-stage surgeries (68.16 ± 0.88 vs 64.61 ± 0.44) but with no statistically significant relationship (p = 0.187). Stage III colorectal cancer patients who underwent two-stage surgery had a recurrence rate 10% lower than single-stage surgery 40% but with no statistically significant relationship (p = 0.36).
Conclusion: Although not statistically significant, stage III colorectal cancer with acute abdomen who underwent two-stage surgery had a better quality of life and lower recurrence rate compared to patients who underwent two-stage surgery.
Manifestation spectrum of pulmonary metastasis from gynaecological cancer in 2068 subjects over 5-years-observation: what radiologist should consider?
Authors: Sadono Ratya K , Mardiyana Lies , Tjokroprawiro Brahmana A , Wulandari Laksmi 
Published: January 2025

Introduction: Gynaecologic cancer can disseminate to distant organs, such as the lungs, represented by various metastatic patterns. Cytology may aid in detecting metastasis; however, the reported false negative rate is considerably high. Lung biopsy is not always readily accessible, depending on the patient's general condition. Moreover, tumour biomarkers may assist in diagnosing cancer, although not applicable in several types of cancer. In such a situation, radiology plays a substantial role in detecting, characterizing, and restaging the metastatic findings in the thoracal cavity.
Methods: We collected 2068 medical records of patients with gynaecologic cancer between January 2017 and November 2021, supported by histopathologic results from a preoperative sampling method or surgical biopsy during operation. Primary data were extracted from the documents along with the chest radiographs and evaluated using a retrospective descriptive manner.
Results: Four hundred and thirty patients with metastasis findings were assessed. Pleural effusion dominated the metastatic patterns in ovarian cancer; lymphangitic feature in uterine cancer with adenocarcinoma histology and pleural effusion in clear cell cancer; lymphangitic feature in squamous cell carcinoma cervical cancer and pleural effusion in adenocarcinoma; solitary nodule, lymphangitic feature, and pleural effusion in vaginal cancer with squamous cell carcinoma histology; lymphangitic feature in squamous cell carcinoma vulval cancer; and multiple nodules in malignant trophoblastic disease.
Conclusion: Lung metastasis behaviour of gynaecologic cancer can vary widely from pleural effusion to multiple nodules. Radiologists and clinicians are to distinguish those patterns to facilitate diagnosis.
Development of polycystic ovary syndrome – Insulin resistance of rat model using a combination of letrozole and a high-fructose high-cholesterol diet
Authors: Wahyuni Alfaina Wahyuni , Mudigdo Ambar , Soetrisno  , Wasita Brian , Retno Budi Uki , Widyaningsih Vitri 
Published: January 2025

Background: Developing a representative PCOS with insulin resistance (PCOS-IR) animal model is critical for research in PCOS therapy. This project aims to identify a PCOS rat model with hyperandrogenic symptoms and insulin resistance using a combination of letrozole and a high-fructose, high-cholesterol diet. Letrozole, as an enzyme aromatase inhibitor, will induce hyperandrogenemia, while a high-fructose, high-cholesterol diet moisturizes insulin resistance. Both conditions play a role in the pathogenesis of PCOS.
Methods: The study employed the Posttest Only Control Group Design methodology. As samples, 25 female rats were utilized. The control group received only a regular diet, whereas the PCOS-IR model group received 1 mg/kg B.W./day of letrozole orally with a high-fructose, high-cholesterol diet. The treatment was administered on days 18, 21, 24, and 27. Following a 12-hour fast, glucose, insulin, and androgen levels were also determined using the ELISA method. The Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was evaluated. A histological image of ovarian tissue stained with hematoxylin and eosin (H & E) was observed. Image J Application was used to count the number of primers, preantral and antral follicles, corpus luteum, and follicular cysts.
Results: HOMA-IR and androgen levels significantly increased between the control and PCOS groups (p<0.05). The HOMA-IR score and androgen levels significantly increased on days 21, 24, and 27 (p<0.05). There was an increase considerably in the number of corpuses luteum and follicular cysts (p<0.05) on days 18, 21, 24, and 27.
Conclusion: The combination of letrozole and a high fructose high cholesterol diet at 21, 24, and 27 days successfully formed a rat model of PCOS-IR with distinctive endocrine and histological characteristics.
Effect of omega-3 fatty acids on endometriosis: A systematic review
Authors: Harzif Achmad Kemal , Ummah Nafi'atul , Puspawardani Aisyah Retno , Nurbaeti Putri , Wiweko Budi 
Published: January 2025

Introduction: Endometriosis is a term for an inflammatory condition where endometrium tissue develops outside the uterus. Endometriosis affects about 190 million reproductive-aged women. While medical and surgical therapies are essential, adding dietary supplementation may increase the effectiveness of treatment. This study aims to provide evidence on the effect of omega-3 in endometriosis.
Method: We searched PubMed, Scopus, and Cochrane databases for articles published up to November 2023 with keywords related to omega-3 and endometriosis. The inclusion criteria are clinical trials and in vivo studies investigating the effect of omega-3 on endometriosis. Exclusion criteria are studies not exclusive to omega-3 intervention and non-English articles.
Results: Our study included six articles comprising two RCTs and four animal studies. The animal studies demonstrated that omega-3 reduced the volume and weight of endometriosis lesions, reduced inflammatory cytokines (TNF, IL-1b, IL-6), and reduced total oxidant status and oxidative stress index levels. However, omega-3 has no significant effect on pain severity and quality of life of endometriosis patients.
Conclusion: Omega-3 fatty acids possess anti-inflammatory properties and have been suggested as a potential therapeutic option for endometriosis. Previous studies have shown that omega-3 positively impacts animal models of endometriosis. However, clinical trials have yet to show any significant benefits. Further randomized controlled trials are needed to evaluate the clinical effectiveness of omega-3 for endometriosis.
Allogeneic human umbilical cord mesenchymal stem cell secretome effect on apoptosis of HeLa cells
Authors: Erfiandi Febia , Harsono Ali Budi , Faried Ahmad , Winarno Gatot Nyarumenteng Adhipurnawan , Salima Siti , Mantilidewi Kemala Isnainiasih , Anggraeni Tricia Dewi , Sartika Cynthia Retna , Mulyantari Ayu Insafi , Kireina Jessica , Chouw Angliana 
Published: January 2025

Introduction: Cervical cancer treatment typically involves surgery, chemotherapy, and radiotherapy. However, exploring novel treatment approaches is crucial. Stem cell secretome therapy provides new insights as an additional option in the treatment of gynecological cancer. The present study evaluated the impact of the human umbilical cord mesenchymal stem cell (hUCMSC) secretome on cervical cancer, utilizing the HeLa cell line under normoxic and hypoxic conditions.
Patients and methods: HeLa cell apoptotic index was analyzed through flow cytometry at 24 and 48 h post-secretome (at concentrations of 25% and 50%) under normoxic and hypoxic conditions, while the cell viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
Results: The results of the present study revealed that, under normoxic conditions at both incubation periods, secretome treatment at various concentrations resulted in an increased apoptotic index, with a corresponding reduction of cell viability compared with the control. By contrast, secretome administration for 24 h under hypoxic conditions resulted in a reduced apoptotic index and enhanced cell viability. However, after 48 h incubation, the apoptotic index increased and the cell viability diminished following administration of a 50% secretome concentration.
Conclusion: The present study offers insights into how the allogeneic hUCMSC secretome may affect apoptosis in cervical cancer cells under different oxygen levels. These findings highlighted that the anti-cancer effects of secretome were concentration-, oxygen-, and time-dependent. However, its impact in hypoxic environments requires further investigation.
Relationship between serum Glial Fibrillary Acidic Protein (GFAP) levels and severity of traumatic brain injury as measured by Glasgow Coma Scale (GCS) and Rotterdam Computed Tomography (CT) score
Authors: Chandra David , Airlangga Prananda Surya , Hamzah  , Santoso Kohar Hari , Sumartono Christrijogo 
Published: January 2025

Background: Traumatic brain injury is a serious physical injury that can cause brain function impairment. Evaluating the severity of traumatic brain injury is crucial for patient management. Glial Fibrillary Acidic Protein (GFAP) has been identified as a potential biomarker for brain injury. This study aims to evaluate the relationship between serum GFAP levels and the severity of traumatic brain injury measured using the Glasgow Coma Scale (GCS) and Rotterdam Computed Tomography (CT) score.
Methods: This study was conducted using a cross-sectional design to analyse the relationship between GFAP, GCS, and Rotterdam CT score. Data were collected from traumatic brain injury patients in the Emergency Department, Dr. Soetomo Surabaya Regional Hospital during the period from July 1, 2023, to November 30, 2023. GFAP levels were measured using the enzyme-linked immunosorbent assay (ELISA) method from blood serum samples.
Results: Patients with traumatic brain injury showed an average increase in GFAP levels of 1.65 µg/L and an increase in Rotterdam CT score with an average score of 4. GFAP levels increased with decreasing GCS score, indicating a relationship between GFAP and the severity of brain injury. There was a positive correlation between increased GFAP and increased Rotterdam CT score, indicating a pathological response to brain injury.
Conclusion: This study demonstrates that serum GFAP levels correlate with the severity of traumatic brain injury measured using GCS and Rotterdam CT score.