bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of natriuretic peptide polymorphisms on diastolic and metabolic function in a populational cohort: insights from the STANISLAS cohort
Authors: Xhaard Constance , Rouget Raphaël , Vodovar Nicolas , Le Floch Edith , Dandine‐Roulland Claire , Wagner Sandra , Bacq‐Daian Delphine , Thuillier Quentin , Boivin Jean‐Marc , Branlant Christiane , Deleuze Jean‐François , Behm‐Ansmant Isabelle , Zannad Faiez , Rossignol Patrick , Girerd Nicolas 
Published: November 2021

AbstractAimsElevated brain natriuretic peptide (BNP) and the N‐terminal fragment of its pro‐hormone (NT‐proBNP) have become established biomarkers for heart failure and are associated with cardiovascular morbidity and mortality. Investigating sources of inter‐individual heterogeneity, particularly genetic factors, could help better identify patients at risk of future cardiovascular disease. The aim of this study was to estimate the heritability of circulating NT‐proBNP levels, to perform a genome‐wide association study (GWAS) and gene‐candidate analysis focused on NPPB–NPPA genes on these levels, and to examine their association with cardiovascular or metabolic outcomes.Methods and resultsA total of 1555 individuals from the STANISLAS study were included. The heritability of circulating NT‐proBNP levels was estimated at 15%, with seven single nucleotide polymorphisms (SNPs) reaching the significant threshold in the GWAS. All above SNPs were located on the same gene cluster constituted of MTHFR, CLCN6, NPPA, NPPB, and C1orf167. NPPA gene expression was also associated with NT‐proBNP levels. Moreover, six other SNPs from NPPA–NPPB genes were associated with diastolic function (lateral e′ on echocardiography) and metabolic features (glycated haemoglobin).ConclusionsThe heritability of natriuretic peptides appears relatively low (15%) and mainly based on the same gene cluster constituted of MTHFR, CLCN6, NPPA, NPPB, and C1orf167. Natriuretic peptide polymorphisms are associated with natriuretic peptide levels and diastolic function. These results suggest that natriuretic peptide polymorphisms may have an impact in the early stages of cardiovascular and metabolic disease.
A novel ultrasound‐assisted vacuum drying technique for improving drying efficiency and physicochemical properties of Schisandra chinensis extract powder
Authors: Wang Xuecheng , Xu Shijun , Wu Zhicheng , Li Yuanhui , Wang Yaqi , Wu Zhenfeng , Zhu Genhua , Yang Ming 
Published: November 2021

AbstractSchisandra chinensis (S. chinensis) extract powder is an important intermediate for the preparation of many prepared medicines and health products. The physicochemical properties of S. chinensis extract powder have been found to vary tremendously and this has been attributed to the long drying time in the traditional drying method. In this study, S. chinensis specimens were authenticated as the dry fruit of S. chinensis (Turcz.) Baill. S. chinensis were extracted twice with 8 L kg−1 (liquid to solid ratio) distilled water. The extracts were mixed and concentrated under reduced pressure to 1.24 g cm−3. Ultrasound‐assisted vacuum drying (UAVD) was employed as a new approach to improve the efficiency in drying S. chinensis extract powder and produce a higher quality product. The effects of drying temperature (70, 80, 90°C), ultrasonic power (40, 120, 200 W), and ultrasonic application time (4, 12, 20 min every 20 min) on the kinetics and quality of S. chinensis extract were investigated and compared with the conventional vacuum drying (CVD). It was shown that, with the increase in drying temperature, ultrasonic power, and time of UAVD, the drying time for S. chinensis extract to reach the equilibrium moisture decreased. The drying time was reduced by more than 25% when utilizing UAVD compared to the CVD method. The effective moisture diffusivity (Deff) values for CVD and UAVD were 3.48 × 10–9 m2·s–1 and 7.41 × 10–9 m2 s–1, respectively, at the drying temperature of 80°C, indicating an increase of 112.93%. It was also found that a Weibull distribution model was suitable for predicting the moisture content of S. chinensis extract (R2 > 0.95). Furthermore, the content of Schisandrol A in the extracts obtained from UAVD was 12.79% higher than that obtained using CVD at 90°C. This demonstrates that UAVD is an efficient drying technique for S. chinensis extract.
Mortality risk factors in kidney‐transplanted patients with COVID‐19: A systematic review and regression analysis
Authors: Navari Yasaman , Bagheri Amir Behzad , Akhavan Rezayat Arash , SeyedAlinaghi SeyedAhmad , Najafi Sara , Barzegary Alireza , Asadollahi‐Amin Ali 
Published: November 2021

AbstractBackground and aimsThe kidney transplant patients who receive immunosuppressive and specific medication may lead to different mortality risk factors between kidney transplant patients with COVID‐19 and the general population. We aimed to provide a model predictor and a risk analysis of mortality in kidney transplant COVID‐19 positive patients.MethodsWe performed our search using PubMed, MEDLINE, Web of Science, Scopus, and Google Scholar to identify English articles published from the beginning of December 2019 through August 2020. Excluded manuscripts had no full text, lacked information, were not the original article, or consisted of less than three cases. We gathered information about demographic information, comorbidities, COVID‐19 symptoms, lung radiographic findings, history of medication therapy, and changes in the kidney maintenance therapy after confirming their COVID‐19 on the data extraction forms.ResultsWe found a total of 31 eligible articles. We set a 10% mortality rate as our cutoff point. The most common sign and symptoms were cough (53.22 [29.42]), dyspnea (50.80 [24.55]). In the bivariate analysis, fatigue (P = .04, OR of 0.92; 95% CI: 0.85‐1.00), hypertension (P = .07, OR of 1.03; 95% CI: 1.00‐1.07), and dyspnea (P = .08, OR of 1.04; 95% CI: 1.00‐1.09) showed a statistically significant relationship with increases in mortality.In multivariate regression analysis, an independent association was only found between hypertension and mortality (P = .035; AOR of 1.064; CL: 1.004‐1.127).ConclusionClinicians should pay special attention to modifiable risk factors for COVID‐19 infection mortality, such as hypertension among kidney transplant patients, because it may be possible to decrease mortality by controlling these factors.
The positive threshold of the immunohistochemical parameter Ki67 for predicting the recurrence of cervical cancer
Authors: Tu Yuan , Jiang Peng , Zhang Jingni , Jiang Shan , Yi Qianlin , Yuan Rui 
Published: November 2021

AbstractObjectiveTo find the optimal threshold of Ki67 and evaluate its significance in predicting recurrence of stage I–II cervical cancer.MethodsA total of 1130 patients were included after screening. Univariate and multivariate Cox regression analysis were used to select factors associated with recurrence of cervical cancer. The receiver operating characteristic (ROC) curve was used to assess the optimal threshold of Ki67. The differences of clinicopathological parameters and the survival analysis between the two groups divided based on the optimal threshold of Ki67 were compared.ResultsMultivariate Cox regression analysis showed that Ki67 (p < 0.001) was significant prognostic predictor for recurrence of cervical cancer. The optimal threshold of Ki67 was 42%. The recurrence‐free survival (RFS) and the overall survival (OS) of cervical cancer patients in the high‐Ki67 group (Ki67≥42%) were much lower than those in the low‐Ki67 group (Ki67<42%) (p < 0.001, p < 0.001). Among the 380 patients with low‐risk cervical cancer, the RFS and OS of patients in the high‐Ki67 group were also lower than those in the low‐Ki67 group (p < 0.001, p < 0.001).ConclusionThe Ki67 was a useful prognostic factor in patients with stage I–II cervical cancer, and the Ki67 labeling index 42.0% was optimal threshold for predicting recurrence.
Serum HE4 is associated with clinical prognostic factors and survival outcome in female patients with primary peritoneal carcinoma
Authors: Mi Dong , Zhang Yuexiang , Chen Shuqin 
Published: November 2021

AbstractObjectiveThe aim of this study was to investigate whether serum HE4 was associated with clinical risk prognostic factors and survival outcome.MethodsIn this study, 72 patients with primary peritoneal carcinoma (PPC) from January 2011 to October 2019 participated. Serum HE4 and CA125 levels were detected at primary diagnosis, post‐surgery, pre‐recurrence and the presence of recurrence. The relations between serum HE4 levels with clinical prognostic factors were analyzed, and the hazard ratios between serum HE4 levels with overall survival and recurrence‐free survival were also analyzed by univariate and multivariate survival analysis.ResultsHE4 and CA125 levels were significantly elevated in serous type, high histological grade, advanced stage and positive lymph node status and residual tumor diameter more than 1 cm, respectively, compared with those in non‐serous type, low histological grade, early stage, negative lymph node status and residual tumor diameter no more than 1 cm, respectively. HE4 was an independent prognostic factor for recurrence‐free survival and overall survival with hazard ratios of 5.36 (95% confidence interval: 2.19–13.15) and 4.48 (95% confidence interval: 1.87–10.74), respectively.ConclusionHE4 is correlated with clinical risk prognostic factors in PPC and is effective in the recurrence detection and predicting outcome in PPC patients.
PsychOpen CAMA: Publication of community‐augmented meta‐analyses in psychology
Authors: Burgard Tanja , Bosnjak Michael , Studtrucker Robert 
Published: November 2021

AbstractTo enable optimal decision‐making based on the best evidence available, open syntheses are called for. To make data accessible and comprehensible even for decision‐makers without proficient knowledge in meta‐analysis, a graphical user interface (GUI) provides flexible data visualizations including interpretation aids. Moreover, due to a growing number of research findings, efficient and easy updating of meta‐analyses is crucial to prevent waste in research. One label for a concept to meet these needs is community‐augmented meta‐analysis (CAMA). The research community at the one hand feeds the data repository of a CAMA with new data and on the other hand benefits from easy access to data and meta‐analyses on a GUI. PsychOpen CAMA has been released recently to serve the psychological research community as a whole by covering a broad scope of potential research domains. PsychOpen CAMA relies on a web application with an OpenCPU server for the R calculations. To achieve interoperability of different datasets with the analysis functions used in PsychOpen CAMA, a template for meta‐analytic data and machine‐readable metadata are used. In the future, the automation of workflows, flexibility of analysis options, and the scope of the platform will be further developed by making use of synergies with other resources and tools at ZPID. The article provides an overview on the rationale for the necessity of open syntheses and the CAMA approach, as well as a presentation of the architecture, user interface, functionalities and future challenges of PsychOpen CAMA.
3D Printable and Sub‐Micrometer Porous Polymeric Monoliths with Shape Reconfiguration Ability by Miniemulsion Templating
Authors: Lo Tzu‐Hsuan , Yu Sheng‐Sheng 
Published: November 2021

AbstractPorous monoliths prepared by high internal phase emulsion (HIPE) templating have received various attentions in the fields of catalysis, separation, and tissue engineering. However, the application of the monoliths from HIPE is limited by their poor mechanical performance and the difficulty of fabricating hierarchically porous structures. Additive manufacturing is an emerging technique that achieves high design freedom by depositing materials layer‐by‐layer. This work designs medium internal phase emulsion (MIPE) ink with the concept of miniemulsion to prepare 3D printable porous polymeric monoliths with sub‐micrometer pores. High shear energy is used to reduce the droplet size of the internal phase and jam the emulsion ink. The jammed MIPE ink shows prominent shear‐thinning behavior and appropriate elastic modulus for direct ink writing (DIW). After printing, the external phase composed of stearyl acrylate and hexanediol diacrylate can be cured by photopolymerization to produce poly(MIPE) with interconnected pores in the size of several hundred nanometers. The printed poly(MIPE) demonstrates high mechanical strength and can be reprogrammed into complex geometries difficult for the common DIW processes. The proposed technique provides a new route to fabricate hierarchically porous monoliths with a drastic change of pore dimension, high mechanical strength, and tunable shape reconfiguration.
Polymer‐based microfluidic devices: A comprehensive review on preparation and applications
Authors: Han Xue , Zhang Yonghui , Tian Jingkun , Wu Tiange , Li Zongwen , Xing Fei , Fu Shenggui 
Published: November 2021

AbstractAs key components in life science, microfluidics devices play increasingly important roles in the fields of biomedicine, pharmaceuticals, and biology due to its high detection efficiency. Also, microfluidics devices have many applications in label‐free detection, thanks to their low cost and ease of operation. Traditionally, microfluidic devices are fabricated with glass and silicon materials. As an alternative, polymer materials are commonly used in the fabrication of microfluidic devices for their lower cost, versatile fabrication methods, biocompatibility, and repeatability. In this review, the methods for fabricating polymer microfluidic systems are described in detail, including lithography, hot embossing and imprinting, soft lithography, laser ablation, 3D printing, and other technologies. In particular, the merits and demerits of each of the methods are discussed comprehensively. This review also focuses on the applications of polymer‐based microfluidic systems in the areas of biology, medicine and production, typical application scenarios including blood, tumor cell and nucleic acid testing, oil adsorption detection, and pesticide detection. This review emphasizes the device preparation methods and application scenarios of polymer‐based microfluidic systems and was expected to arise more extensive discussions in this field.
Interdisciplinary teams: A model to support students with autism
Authors: Kunze Megan , Machalicek Wendy 
Published: November 2021

AbstractTo present interdisciplinary teams (IDTs) as foundational to effective assessment for students with autism spectrum disorder (ASD). This conceptual paper encourages IDTs by (a) presenting practice guidelines and research supporting effective IDTs; (b) describing vital team characteristics; (c) introducing a new model of teaming practices with a clinical case example; and (d) discussing IDT implementation barriers and recommendations specific to professionals supporting students with ASD. IDT members (e.g., school psychologists, teachers, behavior analysts, occupational therapists, speech‐language pathologists) should use assessment results to navigate goal‐setting and intervention planning allowing students with ASD to benefit from several therapeutic and educational approaches. Skilled professionals support a student's educational trajectory, increasing the likelihood of meeting developmental and academic milestones, and, ultimately leading to better life opportunities.
The accuracy and precision of birthplace reporting in the 1851–1911 censuses: Place as a component of identity in nineteenth‐century England and Wales
Authors: Day Joseph 
Published: November 2021

AbstractIf migration between 1851 and 1911 is to be analysed using individual‐level census data, it must be proven that individuals' place of birth was reliably recorded. However, existing studies have primarily been concerned with establishing only the level of absolute error, rather than how such errors were introduced. Through assessing the determinants of inaccuracy in the 1851–1911 censuses, this article finds that while birthplaces were generally reported accurately, the errors which did exist were not only the fault of the individual in question, but also of the householder whose responsibility it was to fill in the census form, and of those charged with transcribing the original, handwritten schedules into a machine‐readable format. By demonstrating that individuals' ability to identify their place of birth was a function of their age and the distance they migrated from their place of birth, rather than either their intelligence or familiarity with their place of birth per se, shows that individuals' ability to identify their birthplace accurately was a function of the relevance it held in their lives. Consequently, this article argues that individuals' ability to identify their place of birth reflected its role as a component of their identity, becoming less relevant the further from it they became, but increasingly relevant as they aged.
Costs and benefits of living in a vegetated, compared with non‐vegetated, enclosure in male Japanese macaques (Macaca fuscata)
Authors: Alejandro Josue , Huffman Michael A. , Bercovitch Fred B. 
Published: November 2021

AbstractImproving captive environments for primates has been an important tool to enhance animal welfare. One method has been to provide primates with naturalistic vegetated enclosures to promote species‐specific behaviors, enhancing interactions with their social and natural environment, such as an increase in feeding, foraging, and positive social behaviors such as play. To investigate the benefits in which living in naturalistic environments promote general animal well‐being, we observed immature and adult males living in two outdoor housed groups of Japanese macaques (Macaca fuscata) in the Kyoto University Primate Research Institute (KUPRI), Inuyama, Japan, from June of 2015 until June 2016. One enclosure was naturally vegetated and the other was not. We recorded male activity budgets, affiliative (groom, play) behaviors, and rates of agonistic interactions. To examine health status, we recorded and compared coat conditions for both groups. We found that males in the vegetated enclosure spent more time in social play than males in the non‐vegetated enclosure, while males in the non‐vegetated enclosure displayed more stereotypic behaviors and agonistic interactions. We recorded better coat conditions in the vegetated enclosure males while rates of social grooming or self‐grooming were no different between males in the two enclosures. The males in the vegetated enclosure did not have activity budgets more similar to their wild counterparts; but they spent more time in feeding‐related activities and less time resting, which was more similar to their wild counterparts than males in the non‐vegetated enclosure. Our findings suggest that individuals housed in naturalistic environments have significantly greater behavioral and physical markers of wellbeing than those housed in unnatural, large outdoor enclosures. Although we found that males in both types of enclosures overall had similar time budgets to males in the wild, the detailed behavioral and health results suggest that the welfare benefits to males were greater in the vegetated enclosure, compared with non‐vegetated enclosures. Efforts to mimic more natural environments should promote the well‐being of primates.
Comparison of non-invasive Staphylococcus aureus sampling methods on lesional skin in patients with atopic dermatitis
Authors: Lagler Heimo , Bangert Christine , Quint Tamara , Österreicher Zoe , Nussbaumer-Pröll Alina , Eberl Sabine , Weber Maria , Karer Matthias , Sommer Morten O. A. , Zeitlinger Markus 
Published: November 2021

Abstract
There is evidence that Staphylococcus aureus colonisation is linked to severity of atopic dermatitis. As no gold standard for S. aureus sampling on atopic dermatitis skin lesions exists, this study compared three commonly used methods. In addition, effectiveness of standard skin disinfection to remove S. aureus colonisation from these inflamed skin lesions was investigated. In 30 atopic dermatitis patients, three different S. aureus sampling methods, i.e. detergent scrubbing, moist swabbing and tape stripping, were performed on naïve and disinfected skin lesions. Two different S. aureus selective media, mannitol salt agar and chromID agar, were used for bacterial growing. Quantifying the S. aureus load varied significantly between the different sampling methods on naïve skin lesions ranging from mean 51 to 1.5 × 104 CFU/cm2 (p < 0.001). The qualitative detection on naïve skin was highest with the two detergent-based techniques (86% each), while for tape stripping, this value was 67% (all on chromID agar). In comparison, mannitol salt agar was less sensitive (p < 0.001). The disinfection of the skin lesions led to a significant reduction of the S. aureus load (p < 0.05) but no complete eradication in the case of previously positive swab. The obtained data highlight the importance of the selected sampling method and consecutive S. aureus selection agar plates to implement further clinical studies for the effectiveness of topical anti-staphylococcal antibiotics. Other disinfection regimes should be considered in atopic dermatitis patients when complete de-colonisation of certain skin areas is required, e.g. for surgical procedures.
Advantages of petrosectomy for superficial temporal artery to superior cerebellar artery bypass based on three-dimensional distance measurements using cadaver heads
Authors: Uda Kenji , Tanahashi Kuniaki , Mamiya Takashi , Kanamori Fumiaki , Yokoyama Kinya , Nishihori Masahiro , Izumi Takashi , Araki Yoshio , Saito Ryuta 
Published: November 2021

AbstractSuperficial temporal artery (STA) to superior cerebellar artery (SCA) bypass is usually performed via the subtemporal approach (StA), anterior transpetrosal approach (ApA), or combined petrosal approach (CpA), but no study has yet reported a quantitative comparison of the operative field size provided by each approach, and the optimal approach is unclear. The objective of this study is to establish evidence for selecting the approach by using cadaver heads to measure the three-dimensional distances that represent the operative field size for STA–SCA bypass. Ten sides of 10 cadaver heads were used to perform the four approaches: StA, ApA with and without zygomatic arch osteotomy (ApA-ZO− and ApA-ZO+), and CpA. For each approach, the major-axis length and the minor-axis length at the anastomosis site (La-A and Li-A), the major-axis length and the minor-axis length at the brain surface (La-B and Li-B), the depth from the brain surface to the anastomosis site (Dp), and the operating angles of the major axis and the minor axis (OAa and OAi) were measured. Shallower Dp and wider operating angle were obtained in the order CpA, ApA-ZO+, ApA-ZO−, and StA. In all parameters, ApA-ZO− extended the operative field more than StA. ApA-ZO+ extended La-B and OAa more than ApA-ZO−, whereas it did not contribute to Dp and OAi. CpA significantly decreased Dp, and widened OAa and OAi more than ApA-ZO+. ApA and CpA greatly expanded the operative field compared with StA. These results provide criteria for selecting the optimal approach for STA-SCA bypass in light of an individual surgeon’s anastomosis skill level.