bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infusing strategic planning with psychoanalytic insight: an exploratory case study
Authors: Gerard Nathan , Allcorn Seth 
Published: November 2021

PurposeThis paper aims to demonstrate the value of combining the strategic planning process with psychoanalytically informed interpretation through an exploratory case study.Design/methodology/approachThe authors present their experiences and findings from a consulting engagement that began as a strategic planning assignment and soon evolved into an opportunity to explore unconscious forces inhibiting organizational change. The authors, trained in both areas, chose to infuse the two into a combined process that ultimately benefited the organization and suggested novel ways to think about the common process of strategic planning going forward.FindingsThe organization's strategic planning process was considerably enhanced, and its outcomes sustained, by illuminating the unconscious forces at work, particularly as they pertain to issues of power and authority in a male organizational culture found to have a profound negative influence upon the quality of the work environment and employee morale. Findings suggest that without a psychoanalytically informed approach, strategic planning would have failed to produce sustainable change.Research limitations/implicationsWhile the findings reported are from a single case study, the themes explored are likely shared across multiple organizations. There is, therefore, significant potential in combining strategic planning with a psychoanalytic approach to improve organizational effectiveness and employee morale.Originality/valueAlthough common in organizations, strategic planning is rarely augmented with psychoanalytic insights. This case study is the first of its kind to show how the two interventions may complement each other.
The vital-immaterial-mediocre multi-criteria decision-making method
Authors: Zakeri Shervin , Ecer Fatih , Konstantas Dimitri , Cheikhrouhou Naoufel 
Published: November 2021

PurposeThis paper proposes a new multi-criteria decision-making method, called the vital-immaterial-mediocre method (VIMM), to determine the weight of multiple conflicting and subjective criteria in a decision-making problem.Design/methodology/approachThe novel method utilizes pairwise comparisons, vector-based procedures and a scoring approach to determine weights of criteria. The VIMM compares alternatives by the three crucial components, namely the vital, immaterial and mediocre criteria. The vital criterion has the largest effect on the final results, followed by the mediocre criterion and then the immaterial criterion, which is the least impactful on the prioritization of alternatives. VIMM is developed in two forms where the first scenario is designed to solve one-goal decision-making problems, while the second scenario embraces multiple goals.FindingsTo validate the method’s performance and applicability, VIMM is applied to a problem of sustainable supplier selection. Comparisons between VIMM, analytic hierarchy process (AHP) and best-worst method (BWM) reveal that VIMM significantly requires fewer comparisons. Moreover, VIMM works well with both fractional and integer numbers in its comparison procedures.Research limitations/implicationsAs an implication for research, we have added the development of the VIMM under fuzzy and grey environments as the direction for optimization of the method.Practical implicationsAs managerial implications, VIMM not only provides less complex process for the evaluation of the criteria in the managerial decision-making process, but it also generates consistent results, which make VIMM a reliable tool to apply to a large number of potential decision-making problems.Originality/valueAs a novel subjective weighting method, there exist five major values that VIMM brings over AHP and BWM methods: VIMM requires fewer comparisons compared with AHP and BWM; it is not sensitive to the number of criteria; as a goal-oriented method, it exclusively takes the decision-making goals into account; it keeps the validity and reliability of the Decision-Makers’ (DMs’) opinions and works well with integer and fractional numbers.
“Through the looking glass: envisioning new library technologies” the scale of Facebook part 2: global governance and legitimacy
Authors: Fernandez Peter 
Published: November 2021

Purpose
Understanding how the intersection of Facebook’s incentives and their potential misalignment with the values of libraries and society is likely to be a driving force in creating the technology of the future.

Design/methodology/approach
This column examines different models Facebook has tried to resolve the legitimacy challenges raised by its massive scale.

Findings
The misinformation example highlighted in the previous column and the XCheck controversy in this part underscore that an organization of Facebook’s size creates problems that may have similar dynamics to smaller social media companies or other large technology companies, but the resolutions to those problems might look very different.

Originality/value
Navigating the challenges of this kind of social media will be one of the primary tests of how libraries deal with technology in the future and set the course for the technology that comes after.
Factors influencing entrepreneurial team (ET) performance in education and childcare franchise: case of Malaysia
Authors: Yi Lim Xtn , Md Isa Filzah , Noor Shaista , Mohd Nor Leilanie 
Published: November 2021

Purpose
Over these recent years, increasing studies have found a higher propensity of firms founded by entrepreneurial teams (ETs) for continuous operation and high performance, compared to firms single-handedly created by an entrepreneur. In spite of the emerging significance of ETs, the number of related studies remains inadequately low, particularly within the context of franchise firms. Therefore, this study aims to explore the factors that influence the ETs’ performance in the Malaysian education and childcare franchise system using a qualitative approach.

Design/methodology/approach
Qualitative Research Strategy has been adopted and 27 ET leaders participated in this study to get the holistic view of factors influencing the entrepreneurial team (ET) performance in education and childcare franchise in Malaysia.

Findings
The results highlight the factors (team leadership, team training, team diversity, team processes, team confidence and team mental models) influencing the entrepreneurial team (ET) performance in education and childcare franchise in Malaysia.

Originality/value
The present study may help to provide useful information to policy makers, which enable them to formulate the strategies franchise ETs performance in Malaysia. As this study provides insight of factors that have an impact on ET performance. A best practice model for education and childcare franchise ETs’ performance is designed.
Sabaeans on the Somali coast
Authors: Prioletta Alessia , Robin Christian Julien , Schiettecatte Jérémie , Gajda Iwona , Nuʿmān Khaldūn Hazzāʿ 
Published: November 2021

AbstractIn 2019, the illegal excavation of an ancient sanctuary on the Somali coast yielded monumental Sabaic inscriptions from approximately the eighth–seventh centuries BCE. The inscriptions, similar in content and script, have shed light on their authors’ origin (Sabaeans presumably from Maʾrib in Yemen), on the location’s cultic nature, and more broadly on Sabaean endeavours to establish an ambitious trade network in the first half of the first millennium BCE for the supply of aromatic resins from across the Horn of Africa in order to convey them to the Near East and Mesopotamia. These inscriptions also highlight mastery of navigation techniques in the Red Sea and the Gulf of Aden as early as the period of the Sabaean mukarribs.
A review of the role of ethanol‐induced adipose tissue dysfunction in alcohol‐associated liver disease
Authors: Gopal Thiyagarajan , Ai Weilun , Casey Carol A. , Donohue Terrence M. , Saraswathi Viswanathan 
Published: November 2021

AbstractAlcohol‐associated liver disease (AALD) encompasses a spectrum of liver diseases that includes simple steatosis, steatohepatitis, fibrosis, and cirrhosis. The adverse effects of alcohol in liver and the mechanisms by which ethanol (EtOH) promotes liver injury are well studied. Although liver is known to be the primary organ affected by EtOH exposure, alcohol's effects on other organs are also known to contribute significantly to the development of liver injury. It is becoming increasingly evident that adipose tissue (AT) is an important site of EtOH action. Both AT storage and secretory functions are altered by EtOH. For example, AT lipolysis, stimulated by EtOH, contributes to chronic alcohol‐induced hepatic steatosis. Adipocytes secrete a wide variety of biologically active molecules known as adipokines. EtOH alters the secretion of these adipokines from AT, which include cytokines and chemokines that exert paracrine effects in liver. In addition, the level of EtOH‐metabolizing enzymes, in particular, CYP2E1, rises in the AT of EtOH‐fed mice, which promotes oxidative stress and/or inflammation in AT. Thus, AT dysfunction characterized by increased AT lipolysis and free fatty acid mobilization and altered secretion of adipokines can contribute to the severity of AALD. Of note, moderate EtOH exposure results in AT browning and activation of brown adipose tissue which, in turn, can promote thermogenesis. In this review article, we discuss the direct effects of EtOH consumption in AT and the mechanisms by which EtOH impacts the functions of AT, which, in turn, increases the severity of AALD in animal models and humans.
Automated machine learning‐based model predicts postoperative delirium using readily extractable perioperative collected electronic data
Authors: Hu Xiao‐Yi , Liu He , Zhao Xue , Sun Xun , Zhou Jian , Gao Xing , Guan Hui‐Lian , Zhou Yang , Zhao Qiu , Han Yuan , Cao Jun‐Li 
Published: November 2021

AbstractObjectivePostoperative delirium (POD) is a common postoperative complication that is relevant to poor outcomes. Therefore, it is critical to find effective methods to identify patients with high risk of POD rapidly. Creating a fully automated score based on an automated machine‐learning algorithm may be a method to predict the incidence of POD quickly.Materials and methodsThis is the secondary analysis of an observational study, including 531 surgical patients who underwent general anesthesia. The least absolute shrinkage and selection operator (LASSO) was used to screen essential features associated with POD. Finally, eight features (age, intraoperative blood loss, anesthesia duration, extubation time, intensive care unit [ICU] admission, mini‐mental state examination score [MMSE], Charlson comorbidity index [CCI], postoperative neutrophil‐to‐lymphocyte ratio [NLR]) were used to established models. Four models, logistic regression, random forest, extreme gradient boosted trees, and support vector machines, were built in a training set (70% of participants) and evaluated in the remaining testing sample (30% of participants). Multivariate logistic regression analysis was used to explore independent risk factors for POD further.ResultsModel 1 (logistic regression model) was found to outperform other classifier models in testing data (area under the curve [AUC] of 80.44%, 95% confidence interval [CI] 72.24%–88.64%) and achieve the lowest Brier Score as well. These variables including age (OR = 1.054, 95%CI: 1.017~1.093), extubation time (OR = 1.027, 95%CI: 1.012~1.044), ICU admission (OR = 2.238, 95%CI: 1.313~3.793), MMSE (OR = 0.929, 95%CI: 0.876~0.984), CCI (OR = 1.197, 95%CI: 1.038~1.384), and postoperative NLR (OR = 1.029, 95%CI: 1.002~1.057) were independent risk factors for POD in this study.ConclusionsWe have built and validated a high‐performing algorithm to demonstrate the extent to which patient risk changes of POD during the perioperative period, thus leading to a rational therapeutic choice.
Predictors and outcomes of respiratory failure among lung transplant patients with COVID‐19
Authors: Lawrence Adrian , Mahan Luke D. , Mohanka Manish R. , Bollineni Srinivas , Kaza Vaidehi , La Hoz Ricardo M. , Zhang Song , Kershaw Corey D. , Terada Lance S. , Torres Fernando , Banga Amit 
Published: November 2021

AbstractBackgroundThere is limited data on the predictors and outcomes of new or worsening respiratory failure among lung transplant (LT) patients with Coronavirus disease 2019 (COVID‐19).MethodsWe included all the LT patients diagnosed with COVID‐19 during a 1‐year period (March 2020 to February 2021; n = 54; median age: 60, 20–73 years; M:F 37:17). Development of new or worsening respiratory failure (ARF) was the primary outcome variable.ResultsThe overall incidence of ARF was 48.1% (n = 26). More than 20% of patients (n = 11) needed intubation and mechanical ventilation. Body mass index > 25 Kg/m2 (adjusted OR: 5.7, .99–32.93; P = .05) and peak D‐dimer levels > .95 mcg/ml (adjusted OR: 24.99, 1.77–353.8; P = .017) were independently associated with ARF while anticoagulation use prior to COVID‐19 was protective (adjusted OR: .024, .001–.55; P = .02). Majority patients survived the acute illness (85.2%). Pre‐infection chronic lung allograft dysfunction (CLAD) was an independent predictor of mortality (adjusted HR: 5.03, 1.14–22.25; P = .033).ConclusionsCOVID‐19 is associated with significant morbidity and mortality among LT patients. Patients on chronic anticoagulation seem to enjoy favorable outcomes, while higher BMI and peak D‐dimer levels are associated with development of ARF. Pre‐infection CLAD is associated with an increased risk of death from COVID‐19.
Global transgenic upregulation of KCC2 confers enhanced diazepam efficacy in treating sustained seizures
Authors: Cheung Dennis L. , Cooke Matthew J. , Goulton Chelsea S. , Chaichim Chanchanok , Cheung Louis F. , Khoshaba Ashor , Nabekura Junichi , Moorhouse Andrew J. 
Published: November 2021

AbstractReduced anticonvulsant efficacy of benzodiazepines is a problem in the treatment of status epilepticus, with up to 50% of patients failing to respond to their first dose. KCC2 is a neuronal K+‐Cl− co‐transporter that helps set and maintain intracellular Cl− concentrations. KCC2 functional downregulation is a potential contributor to benzodiazepine resistance. We tested this idea using male and female doxycycline‐inducible, conditional transgenic mice to increase the functional expression of KCC2 in pyramidal neurons. We administered mice with two doses of the chemoconvulsant kainic acid (5 mg/kg, i.p.) 60 min apart and quantified the resultant seizures with electroencephalography (EEG) recordings. Overexpression of KCC2 prior to the chemoconvulsant challenge did not affect seizure latency or other measures of seizure severity, but it did increase diazepam's efficacy in stopping EEG seizures. Spike rate, time in seizure, and EEG spectral power following diazepam (5 mg/kg, i.p) were all significantly lower in KCC2 overexpression mice as compared to control mice. Our results indicate that, in the context of benzodiazepine resistance during sustained seizures, addressing impaired Cl− homeostasis alone appreciably improves the efficacy of γ‐aminobutyric acid (GABA)ergic inhibition. We therefore suggest the simultaneous targeting of KCC2 and GABAA receptors as a pathway for improving current anticonvulsant therapeutic strategies.
Zero incidence of factor VIII inhibitors and successful haemostatic response in previously factor VIII‐treated patients with haemophilia A switching to turoctocog alfa in a noninterventional study
Authors: Escuriola Ettingshausen Carmen , Katsarou Olga , Kotnik Barbara Faganel , Borel Derlon Annie , Schwarz Rudolf , Ypma Paula F. , Matytsina Irina , Dey Sohan , Schutgens Roger E. G. 
Published: November 2021

AbstractIntroductionTuroctocog alfa (NovoEight®) is a B‐domain‐truncated recombinant factor VIII (FVIII) approved for patients with haemophilia A.AimTo investigate the long‐term safety and efficacy of turoctocog alfa in routine clinical practice.MethodsGuardian 5 was a prospective, multinational, non‐interventional, post‐authorisation safety study. Male previously treated patients (> 150 exposure days [EDs]) of any age with severe/moderately severe haemophilia A (FVIII ≤ 2%) and a negative inhibitor test prior to first dosing (independent of FVIII‐inhibitor history) were included to receive prophylaxis or on‐demand treatment. The primary endpoint was the proportion of patients developing FVIII inhibitors (≥.6 Bethesda Units [BU]) after baseline visit, measured as per routine practice of each study site during clinic visits. Secondary endpoints included haemostatic effect, annualised bleeding rate (ABR), and adverse reactions assessment. The study concluded when 50 patients reached 100 EDs/patient minimum.ResultsSeventy patients were screened and 68 exposed to turoctocog alfa; 63 (92.6%) were on prophylaxis and five received on‐demand treatment. Six (8.8%) patients reported a history of positive inhibitors. During the study, patients were exposed to turoctocog alfa for a mean (standard deviation) of 131.9 (99.0) days/patient. Fifty‐five of 58 patients who completed the study were tested for FVIII inhibitors; no positive tests were reported. Overall success rate of turoctocog alfa for treatment of bleeds was 87.3%. Among patients receiving prophylaxis, median (range) ABR was 1.97 (.0–25.5) bleeds/year; estimated ABR (negative binomial model) was 3.65 (95% confidence interval: 2.53–5.25).ConclusionTuroctocog alfa was safe and efficacious for haemophilia A treatment in routine clinical practice.
Immunohistochemical and immunofluorescence expression profile of lymphatic endothelial cell markers in oral cancer
Authors: Chutipongpisit Kullasit , Parachuru V. Praveen , Friedlander Lara T. , Hussaini Haizal M. , Rich Alison M. 
Published: November 2021

AbstractLymphangiogenesis makes an important contribution to the tumour microenvironment (TME), but little is known about this in oral squamous cell carcinoma (OSCC). Archival formalin‐fixed paraffin‐embedded specimens (28 OSCC, 10 inflamed and 6 normal oral mucosa controls) were processed using immunohistochemistry (IHC) with antibodies against lymphatic markers D2‐40 (podoplanin), LYVE‐1, VEGFR3 and Prox1. After the endothelial cells had been highlighted by the various markers for lymphatic endothelium, the positive stained cells and vessels were identified and counted in a systematic manner to determine microvessel density. Double‐labelling immunofluorescence (DLIF) was used to investigate the specificity of D2‐40 and LYVE‐1 to lymphatic endothelial cells (LECs) as opposed to blood ECs. There was higher D2‐40 and Prox1 lymphatic vessel density (P = .001) in the OSCC group when compared with both control groups. Some malignant keratinocytes expressed lymphatic markers, as did a much smaller number of epithelial cells in the control groups. DLIF showed that no vessels co‐expressed D2‐40/CD34 or LYVE/CD34. Some D2/40+ LVs were LYVE−. D2‐40 was the most specific LEC marker in OSCC tissues. These results establish that the OSCC TME contains significantly more lymphatic vessels expressing D2‐40 and Prox1 than the control groups, which may play a role in facilitating lymphatic invasion and metastases.
Circular RNA‐associated ceRNA network involved in HIF‐1 signalling in triple‐negative breast cancer: circ_0047303 as a potential key regulator
Authors: Darbeheshti Farzaneh , Mahdiannasser Mojdeh , Noroozi Zahra , Firoozi Zahra , Mansoori Behnam , Daraei Abdolreza , Bastami Milad , Nariman‐Saleh‐Fam Ziba , Valipour Elahe , Mansoori Yaser 
Published: November 2021

AbstractThe aggressive and highly metastatic nature of triple‐negative breast cancer (TNBC) causes patients to suffer from the poor outcome. HIF‐1 signalling pathway is a prominent pathway that contributes to angiogenesis and metastasis progression in tumours. On the contrary, the undeniable importance of circular RNAs (circRNAs) as multifunctional non‐coding RNAs (ncRNAs) has been identified in breast cancer. These ncRNAs owing to their high stability and specificity have been becoming a hotspot in cancer researches. circRNAs act as competing endogenous RNAs (ceRNAs) and compete with mRNAs for shared miRNAs, thus modulate gene expression. Since the most dysregulated biological functions in TNBC are associated with cellular invasion, understanding the molecular pathogenesis of these processes is a crucial step towards the development of new treatment approaches. The purpose of this study is to undermine the circRNA‐associated ceRNA network involved in HIF‐1 signalling in TNBC using an integrative bioinformatics approach. In the next step, the novel circ_0047303‐mediated ceRNA regulatory axes have been extracted and validated across TNBC samples. We show that circ_0047303 has the highest degree in the circRNA‐associated ceRNA network and shows a significant up‐expression in TNBC. Moreover, our results suggest that circ_0047303 could mediate the upregulation of key angiogenesis‐related genes, including HIF‐1, EIF4E2 and VEGFA in TNBC through sponging the tumour‐suppressive miRNAs. The circ_0047303 could be a promising molecular biomarker and/or therapeutic target for TNBC.
Morphological diversity within the Ozark minnow (Notropis nubilus: Leuciscidae)
Authors: Berendzen Peter B. , Holmes Sam R. , Abels Jeremy R. , Black Corinthia R. 
Published: November 2021

AbstractThe Ozark minnow, Notropis nubilus, is a small stream fish that has a disjunct distribution in the Ozark Plateau and upper Mississippi River basin. Three reciprocally monophyletic and deeply divergent lineages have been hypothesized within the species based on molecular data. These lineages are allopatric and isolated from each other. The objective of this study was to test the hypothesis that these lineages and the disjunct population in the upper Mississippi River basin are morphologically distinct. Meristic and geometric morphometric data were used to identify and quantify morphological diversity within the Ozark minnow. Analyses of the meristic data and a principal component analysis of the morphometric data were unable to find any noticeable differences in morphology among groups. However, canonical variates analyses of the morphometric data and linear models were able to define statistically significant differences in shape. Analyses of all‐individuals were able to identify shape differences between all groups. Males‐only analyses were less conclusive, but there was some indication that males may be diverging more quickly than all‐individuals. The detection of subtle variation in shape implies selection is not a strong factor in morphological divergence and observed differences are most likely due to morphological drift. This indicates that the lineages within the Ozark minnow are likely on the trajectory for speciation. The allopatric nature of these clades makes the Ozark minnow an interesting model for the study of morphological drift and speciation.