bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two-scale shape optimisation based on numerical homogenisation techniques and variational sensitivity analysis
Authors: Kijanski Wojciech , Barthold Franz-Joseph 
Published: March 2021

AbstractThis contribution presents a theoretical and computational framework for two-scale shape optimisation of nonlinear elastic structures. Particularly, minimum compliance optimisation problems with composite (matrix-inclusion) microstructures subjected to static loads and volume-type design constraints are focused. A homogenisation-based FE$$^2$$

2

scheme is extended by an enhanced formulation of variational (shape) sensitivity analysis based on Noll’s intrinsic, frame-free formulation of continuum mechanics. The obtained overall two-scale sensitivity information couples shape variations across micro- and macroscopic scales. A numerical example demonstrates the capabilities of the proposed variational sensitivity analysis and the (shape) optimisation framework. The investigations involve a mesh morphing scheme for the design parametrisation at both macro- and microscopic scales.
Hypothesis derivation and its verification by a wholly automated many-objective evolutionary optimization system
Authors: Chiba Kazuhisa , Sawahara Masataka , Sumimoto Tsuyoshi , Hatta Taiki , Kanazaki Masahiro 
Published: March 2021

AbstractThis study has constructed a fully automated multidisciplinary and many-objective evolutionary design optimization system independent of computer environments to evaluate objective functions; the research applied it to a geometric design problem of a flyback booster for next-generation space transportation. In optimization involving objective functions to appraise the aero-/structural-dynamic performance with high fidelity, spatial discretization hinders the overall automation. This research has facilitated an efficient optimal design by wholly automating high-fidelity assessments, which designers had to implement manually, and has accomplished optimizations that directly contribute to real-world design problems. Moreover, this study would accumulate design knowledge for space transportation that the market is reviving. The total automated system yielded the embedding of geometric trait lines to ensure the discretization even for large curvature surfaces; the system innovated a robust automatic error-checking mechanism in the system’s preprocess. Consequently, the entirely automatized optimization procured nondominated solution sets for more precise data analyses in a pragmatic execution period. Design informatics, a framework combining optimization and data analysis, functioned usefully in real-world design on flyback-booster geometry by materializing smooth deriving and verifying a design hypothesis; eventually, the research gained a new design principle.
Outcome following mini-open lower limb fasciotomy for chronic exertional compartment syndrome
Authors: Oliver William M. , Rhatigan Dominic , Mackenzie Samuel P. , White Timothy O. , Duckworth Andrew D. , Molyneux Samuel G. 
Published: March 2021

Abstract
Purpose
The aim of this study was to report outcomes following mini-open lower limb fasciotomy (MLLF) in active adults with chronic exertional compartment syndrome (CECS).

Methods
From 2013–2018, 38 consecutive patients (mean age 31 years [16–60], 71% [n = 27/38] male) underwent MLLF. There were 21 unilateral procedures, 10 simultaneous bilateral and 7 staged bilateral. There were 22 anterior fasciotomies, five posterior and 11 four-compartment. Early complications were determined from medical records of 37/38 patients (97%) at a mean of four months (1–19). Patient-reported outcomes (including EuroQol scores [EQ-5D/EQ-VAS], return to sport and satisfaction) were obtained via postal survey from 27/38 respondents (71%) at a mean of 3.7 years (0.3–6.4).

Results
Complications occurred in 16% (n = 6/37): superficial infection (11%, n = 4/37), deep infection (3%, n = 1/37) and wound dehiscence (3%, n = 1/37). Eight per cent (n = 3/37) required revision fasciotomy for recurrent leg pain. At longer-term follow-up, 30% (n = 8/27) were asymptomatic and another 56% (n = 15/27) reported improved symptoms. The mean pain score improved from 6.1 to 2.5 during normal activity and 9.1 to 4.7 during sport (both p < 0.001). The mean EQ-5D was 0.781 (0.130–1) and EQ-VAS 77 (33–95). Of 25 patients playing sport preoperatively, 64% (n = 16/25) returned, 75% (n = 12/16) reporting improved exercise tolerance. Seventy-four per cent (n = 20/27) were satisfied and 81% (n = 22/27) would recommend the procedure.

Conclusion
MLLF is safe and effective for active adults with CECS. The revision rate is low, and although recurrent symptoms are common most achieve symptomatic improvement, with reduced activity-related leg pain and good health-related quality of life. The majority return to sport and are satisfied with their outcome.
Mineral resource dissipation in life cycle inventories
Authors: Beylot Antoine , Ardente Fulvio , Sala Serenella , Zampori Luca 
Published: March 2021

Abstract
Purpose
The assessment of potential environmental impacts associated to mineral resource use in LCA is a highly debated topic. Most current impact assessment methods consider the extraction of resources as the issue of concern, while their dissipation is an emerging concept. This article proposes an approach to account for mineral resource dissipation in life cycle inventories (LCIs), with application to a case study.

Methods
The definition of mineral resources is first discussed considering both current main LCA practice and the context of resource dissipation. Secondly, the approach is described: considering a short-term perspective (25 years), any flow of resources to (i) environment, (ii) final waste disposal facilities, and (iii) products-in-use in the technosphere, with the resources not providing any significant function anymore (including due to non-functional recycling), is suggested to be reported as dissipative at the level of unit processes. This approach first requires to map the flows of mineral resources into and out of the unit processes under study (“resource flow analysis”), before identifying the dissipative flows and reporting them in LCI datasets.

Results and discussion
The approach is applied to analyze the direct dissipation of mineral resources along the primary production of copper, using Ecoinvent (v3.5) datasets. The production of 1 kg of copper cathode generates 0.88 kg of direct dissipative flows of resources (primarily calcium carbonate, copper, and to a lower extent iron), with important contributions of “tailings disposal,” “pyrometallurgy,” and “mining and concentration.” Moreover, this article discusses (i) how the developed approach would change the interpretation of results regarding mineral resources in LCA, (ii) how far some key methodological aspects of this approach (e.g., the temporal perspective) can affect the inventory results (e.g., in the case of the primary production of copper, considering a long-term perspective implies a significant shift in main contributions regarding both unit processes and resource flows), and finally (iii) the issue of new data requirements, in terms of availability and adequacy.

Conclusions
As demonstrated in the case study, existing LCI datasets and supporting documentation contain at least part of the data and information required to consistently compile the dissipative flows of resources at the unit process level, yet with the need for some complementary data and assessments. This approach may be particularly relevant to better support the development of more resource-efficient techniques or product designs. It is still open how to adapt characterization approaches to account for the impact induced by these resource dissipative flows.
TEAMwISE: synchronised immersive environments for exploration and analysis of animal behaviour
Authors: Klein Karsten , Aichem Michael , Zhang Ying , Erk Stefan , Sommer Björn , Schreiber Falk 
Published: March 2021

AbstractThe recent availability of affordable and lightweight tracking sensors allows researchers to collect large and complex movement data sets. To explore and analyse these data, applications are required that are capable of handling the data while providing an environment that enables the analyst(s) to focus on the task of investigating the movement in the context of the geographic environment it occurred in. We present an extensible, open-source framework for collaborative analysis of geospatial–temporal movement data with a use case in collective behaviour analysis. The framework TEAMwISE supports the concurrent usage of several program instances, allowing to have different perspectives on the same data in collocated or remote set-ups. The implementation can be deployed in a variety of immersive environments, for example, on a tiled display wall and mobile VR devices.Graphic abstract
Explainable recommendation based on knowledge graph and multi-objective optimization
Authors: Xie Lijie , Hu Zhaoming , Cai Xingjuan , Zhang Wensheng , Chen Jinjun 
Published: March 2021

AbstractRecommendation system is a technology that can mine user's preference for items. Explainable recommendation is to produce recommendations for target users and give reasons at the same time to reveal reasons for recommendations. The explainability of recommendations that can improve the transparency of recommendations and the probability of users choosing the recommended items. The merits about explainability of recommendations are obvious, but it is not enough to focus solely on explainability of recommendations in field of explainable recommendations. Therefore, it is essential to construct an explainable recommendation framework to improve the explainability of recommended items while maintaining accuracy and diversity. An explainable recommendation framework based on knowledge graph and multi-objective optimization is proposed that can optimize the precision, diversity and explainability about recommendations at the same time. Knowledge graph connects users and items through different relationships to obtain an explainable candidate list for target user, and the path between target user and recommended item is used as an explanation basis. The explainable candidate list is optimized through multi-objective optimization algorithm to obtain the final recommendation list. It is concluded from the results about experiments that presented explainable recommendation framework provides high-quality recommendations that contains high accuracy, diversity and explainability.
Gene Expression Profiling of Muscle-Invasive Bladder Cancer With Secondary Variant Histology
Authors: de Jong Joep J , Narayan Vikram M , Cronican Andrea A , Gupta Shilpa , van Leenders Geert J L H , Boormans Joost L , Gibb Ewan A , Konety Badrinath R 
Published: March 2021

Abstract

Objectives
To determine the potential impact of the presence of secondary variant histology on the gene expression profiles of muscle-invasive bladder cancer (MIBC) tumors.

Methods
For six tumors, revised samples were collected from urothelial and secondary variant components (cohort A). The commercial cohort (cohort B) consisted of the anonymized gene expression profiles of 173 patients with MIBC. Samples were obtained from the clinical use of the Decipher Bladder test that were available as part of the Decipher GRID prospective registry (NCT02609269). Secondary variant presence in cohort B was abstracted from institutional pathology reports. For the commercial cohort, only the urothelial carcinoma component was profiled.

Results
Molecular subtyping of both urothelial and variant components found micropapillary and nested cases were classified as a luminal subtype. Conversely, the sarcomatoid and small cell cases were classified as basal/squamous or neuroendocrine-like, respectively. For cohort B, 50 (29%) of 173 cases had reported secondary variant histology. Cases with squamous variant had basal profiles, small cell cases expressed neuronal markers, and micropapillary cases were classified as luminal. Sarcomatoid tumors had robust epithelial-mesenchymal transition marker expression.

Conclusions
Our data suggest that in MIBC with secondary variant, the urothelial component can demonstrate an expression profile that closely resembles the variant component.
The GGC repeat expansion inNOTCH2NLCis associated with oculopharyngodistal myopathy type 3
Authors: Yu Jiaxi , Deng Jianwen , Guo Xueyu , Shan Jingli , Luan Xinghua , Cao Li , Zhao Juan , Yu Meng , Zhang Wei , Lv He , Xie Zhiying , Meng LingChao , Zheng Yiming , Zhao Yawen , Gang Qiang , Wang Qingqing , Liu Jing , Zhu Min , Zhou Binbin , Li Pidong , Liu Yinzhe , Wang Yang , Yan Chuanzhu , Hong Daojun , Yuan Yun , Wang Zhaoxia 
Published: March 2021

AbstractOculopharyngodistal myopathy (OPDM) is an adult-onset neuromuscular disease characterized by progressive ocular, facial, pharyngeal and distal limb muscle involvement. Trinucleotide repeat expansions in LRP12 or GIPC1 were recently reported to be associated with OPDM. However, a significant portion of OPDM patients have unknown genetic causes. In this study, long-read whole-genome sequencing and repeat-primed PCR were performed and we identified GGC repeat expansions in the NOTCH2NLC gene in 16.7% (4/24) of a cohort of Chinese OPDM patients, designated as OPDM type 3 (OPDM3). Methylation analysis indicated that methylation levels of the NOTCH2NLC gene were unaltered in OPDM3 patients, but increased significantly in asymptomatic carriers. Quantitative real-time PCR analysis indicated that NOTCH2NLC mRNA levels were increased in muscle but not in blood of OPDM3 patients. Immunofluorescence on OPDM muscle samples and expressing mutant NOTCH2NLC with (GGC)69 repeat expansions in HEK293 cells indicated that mutant NOTCH2NLC-polyglycine protein might be a major component of intranuclear inclusions, and contribute to toxicity in cultured cells. In addition, two RNA-binding proteins, hnRNP A/B and MBNL1, were both co-localized with p62 in intranuclear inclusions in OPDM muscle samples. These results indicated that a toxic protein gain-of-function mechanism and RNA gain-of-function mechanism may both play a vital role in the pathogenic processes of OPDM3. This study extended the spectrum of NOTCH2NLC repeat expansion-related diseases to a predominant myopathy phenotype presenting as OPDM, and provided evidence for possible pathogenesis of these diseases.
Human tauopathy-derived tau strains determine the substrates recruited for templated amplification
Authors: Tarutani Airi , Miyata Haruka , Nonaka Takashi , Hasegawa Kazuko , Yoshida Mari , Saito Yuko , Murayama Shigeo , Robinson Andrew C , Mann David M A , Tomita Taisuke , Hasegawa Masato 
Published: March 2021

Abstract
Tauopathies are a subset of neurodegenerative diseases characterized by abnormal tau inclusions. Specifically, three-repeat tau and four-repeat tau in Alzheimer’s disease, three-repeat tau in Pick’s disease (PiD) and four-repeat tau in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) form amyloid-like fibrous structures that accumulate in neurons and/or glial cells. Amplification and cell-to-cell transmission of abnormal tau based on the prion hypothesis are believed to explain the onset and progression of tauopathies. Recent studies support not only the self-propagation of abnormal tau, but also the presence of conformationally distinct tau aggregates, namely tau strains. Cryogenic electron microscopy analyses of patient-derived tau filaments have revealed disease-specific ordered tau structures. However, it remains unclear whether the ultrastructural and biochemical properties of tau strains are inherited during the amplification of abnormal tau in the brain. In this study, we investigated template-dependent amplification of tau aggregates using a cellular model of seeded aggregation. Tau strains extracted from human tauopathies caused strain-dependent accumulation of insoluble filamentous tau in SH-SY5Y cells. The seeding activity towards full-length four-repeat tau substrate was highest in CBD-tau seeds, followed by PSP-tau and Alzheimer’s disease (AD)-tau seeds, while AD-tau seeds showed higher seeding activity than PiD-tau seeds towards three-repeat tau substrate. Abnormal tau amplified in cells inherited the ultrastructural and biochemical properties of the original seeds. These results strongly suggest that the structural differences of patient-derived tau strains underlie the diversity of tauopathies, and that seeded aggregation and filament formation mimicking the pathogenesis of sporadic tauopathy can be reproduced in cultured cells. Our results indicate that the disease-specific conformation of tau aggregates determines the tau isoform substrate that is recruited for templated amplification, and also influences the prion-like seeding activity.
Strengthened structure–function relationships of the corticospinal tract by free water correction after stroke
Authors: Guder Stephanie , Pasternak Ofer , Gerloff Christian , Schulz Robert 
Published: March 2021

Abstract
The corticospinal tract is the most intensively investigated tract of the human motor system in stroke rehabilitative research. Diffusion-tensor-imaging gives insights into its microstructure, and transcranial magnetic stimulation assesses its excitability. Previous data on the interrelationship between both measures are contradictory. Correlative or predictive models which associate them with motor outcome are incomplete. Free water correction has been developed to enhance diffusion-tensor-imaging by eliminating partial volume with extracellular water, which could improve capturing stroke-related microstructural alterations, thereby also improving structure-function relationships in clinical cohorts. In the present cross-sectional study, data of 18 chronic stroke patients and 17 healthy controls, taken from a previous study on cortico-cerebellar motor tracts, were re-analysed: The data included diffusion-tensor-imaging data quantifying corticospinal tract microstructure with and without free water correction, transcranial magnetic stimulation data assessing recruitment curve properties of motor evoked potentials and detailed clinical data. Linear regression modelling was used to interrelate corticospinal tract microstructure, recruitment curves properties and clinical scores. The main finding of the present study was that free water correction substantially strengthens structure-function associations in stroke patients: Specifically, our data evidenced a significant association between fractional anisotropy of the ipsilesional corticospinal tract and its excitability (P = 0.001, adj. R2 = 0.54), with free water correction explaining additional 20% in recruitment curve variability. For clinical scores, only free water correction leads to the reliable detection of significant correlations between ipsilesional corticospinal tract fractional anisotropy and residual grip (P = 0.001, adj. R2 = 0.70) and pinch force (P &lt; 0.001, adj. R2 = 0.72). Finally, multimodal models can be improved by free water correction as well. This study evidences that corticospinal tract microstructure directly relates to its excitability in stroke patients. It also shows that unexplained variance in motor outcome is considerably reduced by free water correction arguing that it might serve as a powerful tool to improve existing models of structure-function associations and potentially also outcome prediction after stroke.
Rapid decline of anti-SARS-CoV-2 antibodies in patients on haemodialysis: the COVID-FRIAT study
Authors: Alcázar-Arroyo Roberto , Portolés José , López-Sánchez Paula , Zalamea Felipe , Furaz Karina , Méndez Ángel , Nieto Luis , Sánchez-Hernández Rosa , Pizarro Soledad , García Alicia , Pereira Mónica , Gallego-Valcárcel Eduardo , Llópez-Carratala Rosario , Gadea-Gironés Ignacio , Martín Roberto , Miranda Blanca ,   COVID-FRIAT study group, Cordón Alfredo , Horna Alicia González , Botella Ana , del Real Paula Manso , Hernández Jesús , San Segundo Eva María García , Guerrero José , Acuña Mariano , Rodríguez Elena Guerrero , Ortiz Alberto , Parra Emilio Gonzalez , Juárez Gema Fernández , Gruss Enrique , Barriola Almudena Ortigosa , Rodríguez Laura , Torre Cristina Ledesma , Alexandru Simona , Simón Dolores Piña , Esteras Raquel , González Adriana Iglesias , Marín Darío Janeiro , García Alicia Sánchez , Hernán David , Sánchez Mónica , Portillo Jesús 
Published: March 2021

AbstractBackgroundCoronavirus disease 2019 (COVID-19) patients on haemodialysis (HD) have high mortality. We investigated the value of reverse transcription polymerase chain reaction (RT-PCR) and the dynamic changes of antibodies (enzyme-linked immunosorbent assay immunoglobulin M (IgM) + IgA and/or IgG) in a large HD cohort.MethodsWe conducted a prospective observational study in 10 Madrid HD centres. Infection rate, anti-SARS-CoV-2 antibody dynamics and the incidence of asymptomatic SARS-CoV-2 infection (defined by positive RT-PCR, IgM + IgA and/or IgG) were assessed.ResultsFrom 1 March to 15 April 2020, 136 of 808 (16.8%) HD patients were diagnosed with symptomatic COVID-19 by RT-PCR of nasopharyngeal swabs and 42/136 (31%) died. In the second fortnight of April, RT-PCR and anti-SARS-CoV-2 antibodies were assessed in 763 of the surviving patients. At this point, 69/91 (75.8%) symptomatic COVID-19 patients had anti-SARS-CoV-2 antibodies. Four weeks later, 15.4% (10/65) of initially antibody-positive patients had become negative. Among patients without prior symptomatic COVID-19, 9/672 (1.3%) were RT-PCR positive and 101/672 patients (15.0%) were antibody positive. Four weeks later, 62/86 (72.1%) of initially antibody-positive patients had become negative. Considering only IgG titres, serology remained positive after 4 weeks in 90% (54/60) of patients with symptomatic COVID-19 and in 52.5% (21/40) of asymptomatic patients. The probability of an adequate serologic response (defined as the development of anti-SARS-CoV-2 antibodies that persisted at 4 weeks) was higher in patients who had symptomatic COVID-19 than in asymptomatic SARS-CoV-2 infection {odds ratio [OR) 4.04 [95% confidence interval (CI) 2.04–7.99]} corrected for age, Charlson comorbidity index score and time on HD. Living in a nursing home [OR 5.9 (95% CI 2.3–15.1)] was the main risk factor for SARS-CoV-2 infection.ConclusionsThe anti-SARS-CoV-2 antibody immune response in HD patients depends on clinical presentation. The antibody titres decay earlier than previously reported for the general population. This inadequate immune response raises questions about the efficacy of future vaccines.