bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra-fast dynamic line-field optical coherence elastography
Authors: Singh Manmohan , Schill Alexander W. , Nair Achuth , Aglyamov Salavat R. , Larina Irina V. , Larin Kirill V. 
Published: August 2021

In this work, we present an ultra-fast line-field optical coherence elastography system (LF-OCE) with an 11.5 MHz equivalent A-line rate. The system was composed of a line-field spectral domain optical coherence tomography system based on a supercontinuum light source, Michelson-type interferometer, and a high-speed 2D spectrometer. The system performed ultra-fast imaging of elastic waves in tissue-mimicking phantoms of various elasticities. The results corroborated well with mechanical testing. Following validation, LF-OCE measurements were made in in situ and in in vivo rabbit corneas under various conditions. The results show the capability of the system to rapidly image elastic waves in tissues.
Generation of a dual optical frequency comb by large signal modulation of a semiconductor laser
Authors: Krstić Marko M. , Crnjanski Jasna V. , Banović Mladen Ž. , Vasiljević Ivana S. , Gvozdić Dejan M. 
Published: August 2021

In this paper, we present and theoretically investigate a simple and
power efficient scheme for dual optical frequency comb generation
residing on a single directly modulated semiconductor laser driven by
two superimposed current waveforms. Our detailed model estimates dual
combs comprising teeth pairs within 20 dB margin spanning up to
116 GHz with power per teeth pair up to 8.8 µW. In addition, we report
dual combs with 40 GHz span comprising ultraflat teeth pairs, with
flatness of the order of 1 dB.
Efficacy of the new β-D-glucan measurement kit for diagnosing invasive fungal infections, as compared with that of four conventional kits
Authors: Bamba Yuuki , Nagano Kei , Moro Hiroshi , Ogata Hideyuki , Hakamata Mariko , Shibata Satoshi , Koizumi Takeshi , Aoki Nobumasa , Ohshima Yasuyoshi , Watanabe Satoshi , Nakamura Takeshi , Kobayashi Sugako , Hoshiyama Yoshiki , Koya Toshiyuki , Takada Toshinori , Kikuchi Toshiaki 
Published: August 2021

BackgroundEach of the currently available (1→3)-β-D-glucan (BDG) measurement kits follows a different measurement method and cut-off value. Comparisons of diagnostic performance for invasive fungal infections (IFIs) are desirable. Additionally, ecological considerations are becoming increasingly important in the development of new measurement kits.MethodsThe plasma BDG levels in clinical samples were measured using the following currently available kits: the Fungitec G test MKII, the Fungitec G test ES, Fungitell, the β-Glucan test Wako, and the newly developed Wako kit (Wako-Eu). Wako-Eu uses a pre-treatment solution that conforms to European regulations for the registration, evaluation, authorisation, and restriction of chemicals. The values obtained for the samples using each kit were studied and compared.ResultsOf the 165 patients evaluated, 12 had IFIs, including pneumocystis pneumonia, aspergillosis, and candidiasis. BDG values obtained using the kits were moderately correlated with each other. Clinical diagnoses of the evaluated cases indicated that 21 false positives were diagnosed by at least one kit. The sensitivity of the Fungitell kit was relatively low, but those of the other four were over 90%. The specificity was above 90% for all kits. For positive predictive value, the Wako and the Wako-Eu methods were superior to the others owing to fewer false positive results.ConclusionsThe newly developed Wako-Eu method, which considers ecological concerns, shows diagnostic performance equivalent to that of its predecessor. To improve the diagnostic accuracy of IFIs, it is necessary to interpret the results carefully, giving due consideration to the characteristics of each measurement kit.
“Mass gathering events and COVID-19 transmission in Borriana (Spain): A retrospective cohort study”
Authors: Domènech-Montoliu Salvador , Pac-Sa Maria Rosario , Vidal-Utrillas Paula , Latorre-Poveda Marta , Del Rio-González Alba , Ferrando-Rubert Sara , Ferrer-Abad Gema , Sánchez-Urbano Manuel , Aparisi-Esteve Laura , Badenes-Marques Gema , Cervera-Ferrer Belén , Clerig-Arnau Ursula , Dols-Bernad Claudia , Fontal-Carcel Maria , Gomez-Lanas Lorna , Jovani-Sales David , León-Domingo Maria Carmen , Llopico-Vilanova Maria Dolores , Moros-Blasco Mercedes , Notari-Rodríguez Cristina , Ruíz-Puig Raquel , Valls-López Sonia , Arnedo-Pena Alberto 
Published: August 2021

ObjectiveMass gathering events (MGEs) are associated with the transmission of COVID-19. Between 6 and 10 March 2020, several MGEs related to theFallesfestival took place in Borriana, a municipality in the province of Castellon (Spain). The aim of this study was to estimate the incidence of COVID-19 and its association with these MGEs, and to quantify the potential risk factors of its occurrence.MethodsDuring May and June 2020, a population-based retrospective cohort study was carried out by the Public Health Center of Castelló and the Hospital de la Plana in Vila-real. Participants were obtained from a representative sample of 1663 people with potential exposure at six MGEs. A questionnaire survey was carried out to obtain information about attendance at MGEs and COVID-19 disease. In addition, a serologic survey of antibodies against SARS-Cov-2 was implemented. Inverse probability weighted regression was used in the statistical analysis.ResultsA total of 1338 subjects participated in the questionnaire survey (80.5%), 997 of whom undertook the serologic survey. Five hundred and seventy cases were observed with an attack rate (AR) of 42.6%; average age was 36 years, 62.3% were female, 536 cases were confirmed by laboratory tests, and 514 cases were found with SARS-CoV-2 total antibodies. Considering MGE exposure, AR was 39.2% (496/1264). A dose-response relationship was found between MGE attendance and the disease, (adjusted relative risk [aRR] = 4.11 95% confidence interval [CI]3.25–5.19). Two MGEs with a dinner and dance in the same building had higher risks. Associated risk factors with the incidence were older age, obesity, and upper and middle class versus lower class; current smoking was protective.ConclusionsThe study suggests the significance of MGEs in the COVID-19 transmission that could explain the subsequent outbreak in Borriana.
Sleep disorders and associated factors in children with cerebral palsy
Authors: Patery Sari Wardhani Mahligai , Sunartini Sunartini , Sutomo Retno 
Published: August 2021

Background Sleep disorders are a condition affecting quality and quantity of sleep. Children with cerebral palsy (CP) have higher risk of sleep disorders than those with no chronic disease.
Objective To determine the prevalence and factors associated with sleep disorders in children with CP.
Methods We conducted an analytic, observational study with cross-sectional design in children aged 4-10 years with CP. Subjects were recruited consecutively; children with chronic diseases (cardiovascular, malignancy, chronic obstructive pulmonary disease, and diabetes mellitus) were excluded from the study. Primary data including sociodemographics, intensity of physiotherapy outside Sardjito General Hospital (SGH), sleep hygiene, and sleep disorders were collected from the Children’s Sleep Habit Questionnaire (CSHQ). Secondary data were acquired from medical records, such as type of CP, severity of motor function impairment, presence of epilepsy, intensity of physiotherapy performed at SGH, as well as anti-epileptic, anti-spastic, and sleep-affecting medicines.
Results We found sleep disorders in 64 of 75 (85%) subjects, mostly bedtime resistance (66%). Spastic quadriplegia (OR=3.63; 95%CI 1.82 to15.94) and presence of epilepsy (OR=7.82; 95%CI 1.53 to 39.84) were significantly associated with sleep disorders in children with CP aged 4-10 years.
Conclusion Sleep disorders are common in children with CP, with the majority experiencing bedtime resistance. Sleep disorders are more prevalent in subjects with spastic quadriplegia and epilepsy.
Unbalanced Regulation of α7 nAChRs by Ly6h and NACHO Contributes to Neurotoxicity in Alzheimer's Disease
Authors: Wu Meilin , Liu Clifford Z. , Barrall Erika A. , Rissman Robert A. , Joiner William J. 
Published: August 2021

α7 nicotinic acetylcholine receptors (nAChRs) are widely expressed in the brain where they promote fast cholinergic synaptic transmission and serve important neuromodulatory functions. However, their high permeability to Ca2+also predisposes them to contribute to disease states. Here, using transfected HEK-tsa cells and primary cultured hippocampal neurons from male and female rats, we demonstrate that two proteins called Ly6h and NACHO compete for access to α7 subunits, operating together but in opposition to maintain α7 assembly and activity within a narrow range that is optimal for neuronal function and viability. Using mixed gender human temporal cortex and cultured hippocampal neurons from rats we further show that this balance is perturbed during Alzheimer's disease (AD) because of amyloid β (Aβ)-driven reduction in Ly6h, with severe reduction leading to increased phosphorylated tau and α7-mediated neurotoxicity. Ly6h release into human CSF is also correlated with AD severity. Thus, Ly6h links cholinergic signaling, Aβ and phosphorylated tau and may serve as a novel marker for AD progression.SIGNIFICANCE STATEMENTOne of the earliest and most persistent hypotheses regarding Alzheimer's disease (AD) attributes cognitive impairment to loss of cholinergic signaling. More recently, interest has focused on crucial roles for amyloid β (Aβ) and phosphorylated tau in Alzheimer's pathogenesis. Here, we demonstrate that these elements are linked by Ly6h and its counterpart, NACHO, functioning in opposition to maintain assembly of nicotinic acetylcholine receptors (nAChRs) within the physiological range. Our data suggests that Aβ shifts the balance away from Ly6h and toward NACHO, resulting in increased assembly of Ca2+-permeable nAChRs and thus a conversion of basal cholinergic to neurotoxic signaling.
Residual Water Content and Water Saturation of Bazhenov Formation Cores
Authors: Glotov Anton Vasilievich 
Published: August 2021

Abstract
The article presents a new method of determining the residual water content and water saturation of the Bazhenov rocks formation (unconventional reservoir), which is contingent on the synchronous thermal analysis integrated with gas FT-IR spectroscopy and mass spectroscopy. The studies were executed on extensive factual core material. The combination of thermal and spectrometric methods for the identification of gases which are released during heating of core samples facilitated to analyze the dynamics of water release and proposed methods of its separation accordingly by the degrees of connectivity.
Automate Well Logging Data Interpretation with Digital Assistant
Authors: Akinshin Alexander Vadimovich , Dmitrievskiy Mikhail Vladimirovich , Kantemirov Yuliy Dmitrievich , Bobylev Kirill Dmitrievich 
Published: August 2021

Abstract
Nowadays, digitalization and automation are a common trend for many companies of various areas including the oil and gas production industry. Processes of initial data preliminary analysis (unification, merging, depth shifting) and petrophysical preparation for calculations (lithology differentiation, averaging, measurements calculation etc.) in the framework of geophysical well logging (GWL) data interpretation take a significant amount of time. Incorporation of automation algorithms tuned for specific sediments enables to considerably reduce labour effort what increases the time needed for the analytical part of the interpretation. The developed approach is an integrated algorithm which helps to perform preliminary preparation and interpretation of GWL data in the framework of integrated adjustable process with minimum participation of the interpreter in routine operations. The features of the virtual assistant are coded in Python.
The Use of Quantum Dot Inflow Tracers in Multi-Well Reservoir Production Surveillance and Inter-Well Diagnostics
Authors: Dulkarnaev Marat Rafailevich , Malyavko Evgeny Alexandrovich , Semyonova Ekaterina Evgenievna , Gorbokonenko Oksana Alexandrovna , Kotenev Yuri Alexeyevich , Sultanov Shamil Khanifovich , Chibisov Alexander Viacheslavovich , Chudinova Daria Yuryevna 
Published: August 2021

Abstract
Reservoir pressure maintenance is an extremely important factor in field development. In enhanced oil recovery water flooding projects, it is essential to optimize the flooding efficiency in a timely manner and reduce uncertainties in inter-well hydrodynamic modelling.
Usually, the inter-well space parameters are assessed using interference tests or tracer- based surveillance. These methods offer such advantages as reliable information on the flow communication in the target area and the reservoir connectivity in different zones of the field. However, the duration and cost of the described surveillance technologies pose a significant drawback, and therefore alternative physical and mathematical methods with simplified forecast models are widely spread.
This paper describes a method for integrating the results of dynamic marker-based inflow production surveillance in horizontal wells and the Spearman's rank-order correlation method. This approach is applied to provide better interventions for reservoir pressure maintenance, optimization of in-fill drilling, update existing hydro-dynamic models and reduce the level of uncertainty in decision making.
An Optimized Experimental Investigation of Foam-Assisted N2 Huff-n-Puff Enhanced Oil Recovery in Fractured Shale Cores
Authors: Xiong Xiaofei , Sheng James Jia 
Published: August 2021

Abstract
Sustainable development of shale reservoirs and enhanced oil recovery have become a challenge for the oil industry in recent years. Shale reservoirs are typically characterized by nano Darcy-scale matrix, natural fractures, and artificially fractures with high permeability. Some of earlier studies have confirmed that gas huff-n-puff has been investigated and demonstrated as the most effective and promising solution for improving oil recovery in tight shale reservoirs with ultra-low permeability. Fractures provide an advantage in enhancing recovery from shale reservoirs but they also pose serious problems such as severe gas channeling, which led to rapid decline production from a single well. More studies are needed to optimize the process.
This paper studies the method of foam-assisted N2 huff-n-puff to enhance oil recovery in fractured shale cores. The influence of foam on oil recovery was analyzed. The effect of matrix permeability, cycle number and production time on oil recovery are also considered. The shale core used in the experiment was from Sichuan Basin, China. For the purpose of comparation and validation, two groups of tests were conducted. One group of tests was N2 huff-n-puff, and the other was foam-N2 huff-n-puff. In the optimization experiment, matrix permeabilities were set as 0.01mD, 0.008mD and 0.001mD, cycle numbers ranged from one to five, the production time is designed to be 1 hour and 24 hours respectively. During the puff period of experiments, the history of oil recovery was closely monitored to reveal the mechanism.
During a round of gas injection of fractured shale cores, foam-assisted N2 huff-n-puff oil recovery is 4.59%, which is significantly higher than that of N2 huff-n-puff is only 0.0126%, and the contrast becomes more obvious with the increase of matrix permeability. The results also showed that the cumulative oil recovery increased as the number of cycles was increased, with the same experimental conditions. There is an optimal production time to achieve maximum oil recovery. The cycle numbers, matrix permeability, and production time played important roles in foam-assisted N2 huff-n-puff injection process. Therefore, under certain conditions, foam-N2 huff-n-puff has a positive effect on oil development in fractured shale.
LINC00152 Acts as a Potential Marker in Gliomas and Promotes Tumor Proliferation and Invasion Through the LINC00152/miR-107/RAB10 Axis
Authors: Liu Qing , peng gang , su jun , xiao songhua 
Published: August 2021

Abstract
Purpose: Aberrant expression of long noncoding RNAs plays a pivotal role in tumorigenesis. Recently, several studies have showed that the LINC00152 gene is upregulated in a variety of tumors and plays an oncogene role; however, its underlying molecular mechanisms in glioblastoma remain unclear. In this study,we prepare to investigate the biological role and underlying molecular mechanisms of LINC00152 in glioblastoma cells. Methods: Bioinformatics analysis to identify LINC00152 expression, Cell Counting kit-8 assay and Colony formation assay were used to evaluate proliferation, Flow cytometric analysis was used to evaluate apoptosis, Cell Matrigel invasion assay and Wound healing assay was used to evaluate invasion, Western blot analysis to check protein expression level, Mouse xenograft models was used to check cell proliferation in vivo.Results: In this study, we found that LINC00152 was upregulated in gliomas and its expression was significantly associated with high tumor aggressiveness and poor outcomes for glioma patients. Functionally, the knockdown of LINC00152 not only inhibited malignant behaviors of glioma, such as proliferation and invasion of glioma cells and induced apoptosis in vitro but also suppressed tumorigenesis in vivo. Mechanistically, results of the bioinformatics analysis and experimental studies confirmed that LINC00152 and RAB10 as the targets of miR-107, and LINC00152 might act as a sponge for miR-107 to regulate the expression of RAB10 in glioblastoma. Additionally, silencing miR-107 reversed the effects induced by LINC00152 knockdown on glioblastoma cells both in vitro and in vivo. Conclusion: Our data suggested that LINC00152 is a candidate prognostic marker of glioma, and that the LINC00152/MIR-107/RAB10 axis plays a pivotal role in regulation of the glioma malignancy, and therefore, targeting the axis might be an effective therapeutic strategy to treat glioma.
Climate Scenarios And Your Changes In The Life Zone For Brazil
Authors: de Lima Rafael Fausto , OLIVEIRA-APARECIDO LUCAS Eduardo , Lorençone João Antonio , Lorençone Pedro Antonio , de Moraes José Reinaldo da Silva Cabral , de Meneses Kamila Cunha 
Published: August 2021

Abstract
Climate classification systems are tools capable of facilitating the analysis, grouping, delimitation, and dissemination of climatic characteristics of a region, contributing to the delimitation of areas of fitness in the agricultural sector and validation of various models of climate change. Thus, we seek to determine life zones for Brazil using the ecological classification of Holdridge (1967) in different scenarios of climate change. A 30-year historical series (1989-2019) of climatic data of average air temperature (° C) and rainfall (mm) was used for the entire Brazilian territory, obtained through the National Aeronautics and Space Administration / Prediction of World platform Wide Energy Resources - (NASA/POWER). Potential evapotranspiration (PET) was estimated by the method of Camargo (1971) using combinations between annual precipitation, average annual biotemperature, average annual basal biotemperature, and the relationship between evapotranspiration and altitude, the life zones for the Holdridge (1967) system were defined. The scenarios used were based on the IPCC (2014) projections. The average temperature in Brazil ranges from 13.1 to 28.0 ° C and the average annual precipitation is 1467 (± 46.91) mm. In the current scenario for the classification of Holdridge (1967) the predominant zone of life is the humid basal tropical forest in 60.57% of the territory. The increase in temperature causes a predominance of the living zones Basal tropical rainforest in 48.92% for S2 and Basal tropical rainforest in 48.95% in S3, the reduction in precipitation S4 generates the predominance of the living zone Basal tropical forest drought in 49.87%, with the increase in precipitation S5 there is a predominance of the zone of life Low humid basal tropical forest in 50.12% of the territory. The great variability of the obtained life zones makes the Holdridge system a useful tool to validate climate change scenarios.
Predicting The Potential Distribution of Campsis Grandiflora In China Under Climate Change
Authors: Ouyang Xianheng , Pan Jiangling , Wu Zhitao , Chen Anliang 
Published: August 2021

Abstract
As the research of geographical distribution of species shows significant influence on people’s understanding of specie protection and utilization, it is important to study the influence of climate change onto the geographical distribution pattern of plants. Based on 166 distribution records as well as 11 climate and terrain variables with low correlation in China, we used MaxEnt (Maximum Entropy) model and ArcGIS software to predict the potential distribution of Campsis grandiflora under climate change and then determine the dominant climate variables which affect the geographical distribution significantly by analysis. The results show that the area under the curve (AUC) of the train is 0.939, which implies our prediction is accurate. Under the current climate condition, the area of potentially suitable habitat is 238.29×104 km2, mainly distributed in northern China, central China, southern China, and eastern China. The dominant variables affected the geographical distribution of Campsis grandiflora are mean diurnal range, range of annual temperature variation, mean temperature, mean temperature of the coldest season, the driest monthly precipitation, precipitation of the warmest quarter, as well as altitude. In the future climate change scenario, the total area of suitable habitat and highly suitable habitat will increase, whilst the area of moderately suitable habitat and poorly suitable habitat will decrease. In the meantime, the centroid of the potentially suitable area of Campsis grandiflora will migrate to higher latitude areas.
Preliminary Evaluation of the Efficacy and Safety of Brimonidine for General Anesthesia
Authors: Chen Bin , Wang Xiaohui , Shi Mengrou , Li Xin , Zhang Ting , Gao Ping 
Published: August 2021

Abstract
Background:To determine the hypnotic and analgesic effects of brimonidine, and evaluate its efficacy and safety for general anesthesia. Potentiation of pentobarbital sleeping time with brimonidine was observed in mice, as was analgesic activity of brimonidine.Methods:The median effective dose (ED50)and lethal dose (LD50) of intraperitoneally injected brimonidine were determined in hypnotized mice. In addition, LD50 of intravenously injected brimonidine, ED50 of intravenously , intramuscularly and intrarectally injected brimonidine in hypnotized rabbits were determined. The synergistic anesthetic effect of brimonidine and chloral hydrate on rabbits was evaluated. Results:Intraperitoneal injection of 10 mg/kg brimonidine enhanced the hypnotic effect of a threshold dose of pentobarbital. Intraperitoneal injection brimonidine produced dose-related analgesic effects in mice. ED50 of intraperitoneally administered brimonidine in hypnotized mice was 75.7 mg/kg, and LD50 was 379 mg/kg. The ED50 of intravenous, intramuscular and intrarectal brimonidine for hypnosis in rabbits were 5.2 mg/kg, 8.8 mg/kg and 8.7mg/kg, respectively, and LD50 of intravenous brimonidine was 146 mg/kg. Combined intravenous administration of 0.6 mg/kg brimonidine and 0.03 g/kg chloral hydrate had a synergistic anesthetic effects.Conclusions:Brimonidine elicited hypnotic and analgesic effects after systemic administration, and exhibited safety. Brimonidine enhanced the effects of other types of narcotics when combined.