bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vision Deterioration and Hydrocephalus: Rare Presentations of Vestibular Schwannoma and Evolution of Management
Authors: Keulen Marte van , Pace Jonathan , Burant Christopher J. , Penn David L. , Wilson Betsy , Ronald Andrew , Mowry Sarah E. , Megerian Cliff A. , Bambakidis Nicholas C. 
Published: March 2021

Abstract
Introduction The incidence of vestibular schwannoma is reported as 12 to 54 new cases per million per year, increasing over time. These patients usually present with unilateral sensorineural hearing loss, tinnitus, or vertigo. Rarely, these patients present with symptoms of hydrocephalus or vision changes.
Objective The study aimed to evaluate the surgical management of vestibular schwannoma at a single institution and to identify factors that may contribute to hydrocephalus, papilledema, and the need for pre-resection diversion of cerebrospinal fluid.
Patients and Methods A retrospective review examining the data of 203 patients with vestibular schwannoma managed with surgical resection from May 2008 to May 2020. We stratified patients into five different groups to analyze: tumors with a diameter of ≥40 mm, clinical evidence of hydrocephalus, and of papilledema, and patients who underwent pre-resection cerebrospinal fluid (CSF) diversion.
Results From May 2008 to May 2020, 203 patients were treated with surgical resection. Patients with tumors ≥40 mm were more likely to present with visual symptoms (p < 0.001). Presentation with hydrocephalus was associated with larger tumor size (p < 0.001) as well as concomitant visual symptoms and papilledema (p < 0.001). Patients with visual symptoms presented at a younger age (p = 0.002) and with larger tumors (p < 0.001).
Conclusion This case series highlights the rare presentation of vision changes and hydrocephalus in patients with vestibular schwannoma. We recommend urgent CSF diversion for patients with visual symptoms and hydrocephalus, followed by definitive resection. Further, vision may still deteriorate even after CSF diversion and tumor resection.
Croup: A Rare Manifestation of Coronavirus Disease 2019
Authors: Kumar H. C. Krishna , Kumar K. Jagadish , Nadagoud Shaarangdhar , VG Manjunath 
Published: March 2021

AbstractCroup is an acute inflammatory condition affecting upper airways and commonly seen in children with younger age group. Croup is most commonly due to acute viral infection and rarely because of bacterial and atypical agents. Here, we report a 3-month-old child who presented to us with classic signs and symptoms of croup and was also positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Child's mother also tested positive for SARS-CoV-2. SARS-CoV-2 infection presenting with stridor and croup is very rare and probably represents a new manifestation which should be considered in a young infant presenting with croup.
Differences in Temporal Volume between Males and Females and the Influence of Age and BMI: A Cross-Sectional CT-Imaging Study
Authors: Nikolis Andreas , Frank Konstantin , Guryanov Robert , Gombolevskiy Victor , Morozov Sergey , Makhmud Kamal , Chernina Valeria , Gotkin Robert H. , Green Jeremy Blair , Cotofana Sebastian 
Published: March 2021

Abstract
Background The temple has been identified as one of the most compelling facial regions in which to seek aesthetic improvement—both locally and in the entire face—when injecting soft tissue fillers.
Objective The objective of this study is to identify influences of age, gender, and body mass index (BMI) on temporal parameters to better understand clinical observations and to identify optimal treatment strategies for treating temporal hollowing.
Methods The sample consisted of 28 male and 30 female individuals with a median age of 53 (34) years and a median BMI of 27.00 (6.94) kg/m2. The surface area of temporal skin, the surface area of temporal bones, and the temporal soft tissue volume were measured utilizing postprocessed computed tomography (CT) images via the Hausdorff minimal distance algorithm. Differences between the investigated participants related to age, BMI, and gender were calculated.
Results Median skin surface area was greater in males compared with females 5,100.5 (708) mm2 versus 4,208.5 (893) mm2 (p < 0.001) as was the median bone surface area 5,329 (690) mm2 versus 4,477 (888) mm2 (p < 0.001). Males had on average 11.04 mL greater temporal soft tissue volume compared with age and BMI-matched females with p < 0.001. Comparing the volume between premenopausal versus postmenopausal females, the median temporal soft tissue volume was 46.63 mL (11.94) versus 40.32 mL (5.69) (p = 0.014).
Conclusion The results of this cross-sectional CT imaging study confirmed previous clinical and anatomical observations and added numerical evidence to those observations for a better clinical integration of the data.
Comparing plasma conditions in short-pulse-heated foils via fine-structure x-ray emission
Authors: Kraus B. F. , Chien A. , Gao Lan , Hill K. W. , Bitter M. , Efthimion P. C. , Chen Hui , Schneider M. B. , Moreau A. , Hollinger R. , Wang Shoujun , Song Huanyu , Rocca J. J. 
Published: March 2021

Fine-structure x-ray spectra have been measured from foils with embedded tracer layers at two laser facilities. A suite of layered foils with thin Ti tracers under varied tamper layers was studied at both the Titan and the ALEPH 400 nm laser facilities, where Ti Heα emission was recorded using a high-resolution Bragg crystal spectrometer. Several indicators of plasma parameters are examined in the spectra, including temperature- and density-dependent line ratios and line broadening from Stark and opacity effects. Spectra indicate that (1) the plasma density at ALEPH is significantly higher than at Titan and (2) the electron temperature is high for near-surface layers at both facilities but drops more quickly with depth at ALEPH. These inferences of plasma conditions are consistent with differing levels of temporal contrast at each laser facility.
The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism
Authors: Foo Alexander C. Y. , Thompson Peter M. , Chen Shih-Heng , Jadi Ramesh , Lupo Brianna , DeRose Eugene F. , Arora Simrat , Placentra Victoria C. , Premkumar Lakshmanane , Perera Lalith , Pedersen Lars C. , Martin Negin , Mueller Geoffrey A. 
Published: March 2021

Significance
Lipid-enveloped viruses such as flaviviruses and coronaviruses underlie numerous human illnesses. Strategies which target this shared membrane feature may be useful as broad-spectrum antiviral agents. The mosquito protein AEG12 disrupts lipid membranes via delivery of a fatty acid in exchange for diacylphospholipids. This mechanism allows the mosquito to digest red blood cells after a meal and disrupts lipid coat viruses as part of the mosquito immune response to infection. It may be possible to engineer this strategy for human therapeutics.
The diversity and evolution of microbial dissimilatory phosphite oxidation
Authors: Ewens Sophia D. , Gomberg Alexa F. S. , Barnum Tyler P. , Borton Mikayla A. , Carlson Hans K. , Wrighton Kelly C. , Coates John D. 
Published: March 2021

SignificanceGeochemical models of the phosphorus (P) cycle uniquely ignore microbial redox transformations. Yet phosphite is a reduced P source that has been detected in several environments at concentrations that suggest a contemporary P redox cycle. Microbial dissimilatory phosphite oxidation (DPO) converts soluble phosphite into phosphate, and a false notion of rarity has limited our understanding of its diversity and environmental distribution. Here we demonstrate that DPO is an ancient energy metabolism hosted by taxonomically diverse, autotrophic bacteria that exist globally throughout anoxic environments. DPO microorganisms are therefore likely to have provided bioavailable phosphate and fixed carbon to anoxic ecosystems throughout Earth’s history and continue to do so in contemporary environments.
Mesoscale networks and corresponding transitions from self-assembly of block copolymers
Authors: Chang Cheng-Yen , Manesi Gkreti-Maria , Yang Chih-Ying , Hung Yu-Chueh , Yang Kai-Chieh , Chiu Po-Ting , Avgeropoulos Apostolos , Ho Rong-Ming 
Published: March 2021

Significance
Mesoscale networks from the self-assembly of block copolymers (BCPs) demonstrate appealing potentials in a variety of applications such as optical, mechanical, and quantum metamaterials. Herein, three intriguing network phases (double gyroid, double diamond, and double primitive) could be obtained via controlled self-assembly of a simple lamellae-forming polystyrene-block-polydimethylsiloxane diblock copolymer. Kinetically controlled solution-casting and thermal annealing procedures are able to acquire these three metastable phases; in line with the self-consistent field theory, phase transitions start from primitive to diamond, and then to gyroid. Further examinations through small-angle X-ray scattering and electron tomography reveal the phase transitions with epitaxial relationships of the networks and adjustments on curvatures at the high interaction parameter (χ) BCP interface.
Another turn of the screw on the history of the reaction object construction
Authors: Bouso Tamara , Ruano San Segundo Pablo 
Published: March 2021

AbstractThis article deals with the Reaction Object Construction (ROC), as inShe smiled disbelief, where an intransitive verb (smile), by adding an emotional object (disbelief), acquires the extended sense “express X by V−ing” (i.e. “She expressed disbelief by smiling”). Earlier research has suggested a diachronic connection between the ROC and Direct Discourse Constructions (DDCs) of the typeShe smiled, “I don’t believe you”(Visser 1963–1973). More recently,Bouso (2018)has shown that the ROC is primarily a feature of 19th century narrative fiction. This paper aims to bring together these insights. On the basis of a self-compiled corpus and De Smet’sCorpus of English Novels, it investigates the productivity of the ROC in 19th and 20th century fiction, and the role of DDCs in its development. The results reveal a peak in the productivity of the ROC that coincides with the development of the sentimental novel, and a correlation between the development of the ROC on the one hand and of those DDCs that have been mistakenly hypothesised to be its single source constructions on the other. Extravagance is proposed as a triggering factor for the use of the ROC in the 19th century as an alternative to DDCs.
From dynamic modal to conditional protasis connective
Authors: Kuo Yueh Hsin 
Published: March 2021

AbstractThe grammaticalization literature has not demonstrated convincingly how, if at all, dynamic modals may develop into conditional protasis connectives. Drawing on qualitative and quantitative evidence from Chinese, this paper hypothesizes that such a directionality may arise through univerbation between dynamic modals and protasis connectives (e.g.ruò‘if’ +néng‘be able to’ >ruònéng‘if’). Furthermore, this paper suggests that functional compatibility in terms of performativity may explain why dynamic modals tend to grammaticalize into connectives in pre-established conditional protases, while deontic and epistemic modals do so in main clauses.
Exploring the Case: Autour du Louvre-Lens: An Ambitious Tourism Engineering Project
Authors: Ward-Perkins David 
Published: March 2021

Introduction
In France, culture is seen as an economic driver and central government plays a role in driving ambitious cultural initiatives, even at a regional level. This case describes how regional tourism authorities are overcoming the potential clash of perception between a newly established branch of the Louvre Museum in the town of Lens, in Nord-Pas-de-Calais, a region with a strong industrial and working-class culture.
Researchers and students should note that a number of the sources are in French only. However, of the websites of the local authorities, some propose English-language versions; others are presented very visually and the messages will largely be understandable, even to non-French speakers.
Assessment of Gabapentin Misuse using Prescription Drug Monitoring Program Data
Authors: Zhang Yifan , Castracane Alexandria R. , Winstanley Erin L. 
Published: March 2021

Background Gabapentin is an anticonvulsant medication with potential misuse reported in case reports and population studies, highlighting the need to reexamine its abuse liability. The purpose of this study was to describe gabapentin dispensing patterns and assess potential misuse. Methods We used data from Ohio's Prescription Drug Monitoring Program (PDMP) from December 1, 2016 to March 31, 2017 and restricted the population to adults who filled at least one gabapentin prescription ( N = 379,372). Gabapentin dispensing patterns are described and multiple strategies were used to assess potential misuse, including Lorenz-1 curve analysis. Supratherapeutic dosing, number of prescribers and number of pharmacies used were compared for individuals who were co-dispensed medications for opioid use disorder (MOUD) and those who were not. Results More than one million gabapentin prescriptions were dispensed during the 4-month period, with a mean dose of 1103.8 mg. While few individuals received supratherapeutic dosing, exceptionally high doses were observed. Half of the individuals (50.9%) were co-dispensed gabapentin and opioids. The Lorenz-1 value for gabapentin (5.5%) did not exceed the threshold for misuse potential. Individuals co-dispensed MOUD were more likely to have supratherapeutic dosing; however, they had a lower Lorenz-1 value compared to individuals not co-dispensed MOUD. Conclusions Among Ohio residents dispensed gabapentin, there was no evidence of misuse using PDMP data based on the Lorenz-1 value, yet supratherapeutic dosing of gabapentin was observed and was associated with OUD. New strategies may be needed to identify the non-medical use of gabapentin.
Discrete symmetry approach to exact bound-state solutions for a regular hexagon Dirac billiard
Authors: Gaddah Wajdi A 
Published: March 2021

Abstract
We consider solving the stationary Dirac equation for a spin-1/2 fermion confined in a two-dimensional quantum billiard with a regular hexagon boundary, using symmetry transformations of the point group C
6v
. Closed-form bound-state solutions for this problem are obtained and the non-relativistic limit of our results are clearly discussed. Due to an adequate choice of confining boundary conditions the upper components of the planar Dirac-spinor eigenfunctions are shown to satisfy the corresponding hexagonal Schrödinger billiard, and the Dirac positive energy eigenvalues are proven to reduce directly to their Schrödinger counterparts in the non-relativistic limit. An illustrative application of our group theoretic method to the well-known square billiard problem has been explicitly provided. The success of our approach in solving equilateral-triangle, square and regular hexagon quantum billiards may well imply a possible applicability to other regular polygonal billiards. A quick look on nodal domains of the Schrödinger eigenfunctions for the hexagon billiard is also considered. Moreover, we have determined a number of distinct non-congruent polygonal billiards that have the same eigenvalue spectrum as that of the regular hexagon.
Characterization of optogenetically-induced cortical spreading depression in awake mice using graphene micro-transistor arrays
Authors: Masvidal-Codina Eduard , Smith Trevor M , Rathore Daman , Gao Yunan , Illa Xavi , Prats-Alfonso Elisabet , Corro Elena Del , Calia Andrea Bonaccini , Rius Gemma , Martin-Fernandez Iñigo , Guger Christoph , Reitner Patrick , Villa Rosa , Garrido Jose A , Guimerà-Brunet Anton , Wykes Rob C 
Published: March 2021

Abstract

Objective. The development of experimental methodology utilizing graphene micro-transistor arrays to facilitate and advance translational research into cortical spreading depression (CSD) in the awake brain. Approach. CSDs were reliably induced in awake nontransgenic mice using optogenetic methods. High-fidelity DC-coupled electrophysiological mapping of propagating CSDs was obtained using flexible arrays of graphene soultion-gated field-effect transistors (gSGFETs). Main results. Viral vectors targetted channelrhopsin expression in neurons of the motor cortex resulting in a transduction volume ⩾1 mm3. 5–10 s of continous blue light stimulation induced CSD that propagated across the cortex at a velocity of 3.0 ± 0.1 mm min−1. Graphene micro-transistor arrays enabled high-density mapping of infraslow activity correlated with neuronal activity suppression across multiple frequency bands during both CSD initiation and propagation. Localized differences in the CSD waveform could be detected and categorized into distinct clusters demonstrating the spatial resolution advantages of DC-coupled recordings. We exploited the reliable and repeatable induction of CSDs using this preparation to perform proof-of-principle pharmacological interrogation studies using NMDA antagonists. MK801 (3 mg kg−1) suppressed CSD induction and propagation, an effect mirrored, albeit transiently, by ketamine (15 mg kg−1), thus demonstrating this models’ applicability as a preclinical drug screening platform. Finally, we report that CSDs could be detected through the skull using graphene micro-transistors, highlighting additional advantages and future applications of this technology. Significance. CSD is thought to contribute to the pathophysiology of several neurological diseases. CSD research will benefit from technological advances that permit high density electrophysiological mapping of the CSD waveform and propagation across the cortex. We report an in vivo assay that permits minimally invasive optogenetic induction, combined with multichannel DC-coupled recordings enabled by gSGFETs in the awake brain. Adoption of this technological approach could facilitate and transform preclinical investigations of CSD in disease relevant models.
Modeling of Friction Stress in Twin Roll Modules
Authors: Khurramov Sh R 
Published: March 2021

Abstract
The study is devoted to the analysis of the laws of the distribution of tangential friction stresses in twin roll modules. A two-roll module is considered, in which the rolls are positioned relative to the vertical by a slope to the right, have unequal diameters and elastic coatings from materials with different stiffness and friction coefficients, the material layer is sloped downward relative to the center line. Formulas are defined for calculating neutral angles in the considered two-roll module. Dependencies between the forces acting in the rolls and the stresses distributed under the influence of these forces are established. It was revealed that these dependences do not change with a change in the angle of supply of the material layer to the line of centers and the angle of inclination of the upper roll relative to the vertical.
FPGA Based Tsunami Wave Propagation Calculator
Authors: Lavrentiev M M , Lysakov K F , Marchuk An G , Oblaukhov K K , Yu Shadrin M 
Published: March 2021

Abstract
The authors continue to use hardware acceleration to calculate tsunami wave propagation in a few seconds at modern PC. The goal of this work is to develop original implementation the FPGA-based algorithm for nested-grids computations of tsunami wave propagation. The FPGA-based Calculator, for regular grid has been proposed and numerically tested earlier. Use of the nested grid approach makes it possible to calculate wave propagation almost until the shore line. Numerical tests are based on the real digital bathymetry at southern part of Japan. Mesh step variation of the gird is from 180 m to just 7 m. Realistic shape of the initial sea surface displacement at tsunami source was used. The detailed distribution of wave height maxima around and inside the Onahama port have been issued as a result of tsunami generated by a model source located along the Japan deep-water trench. The superfast FPGA calculator provides an opportunity to obtain the calculated wave parameters inside ports and harbours even before arrival of tsunami wave.
Impact of performance expectancy on continuance intention to use e-campus: An empirical study from Malaysia
Authors: Abdul Razak Fahmi Zaidi , Dom Maszita Mohd. , Baharudin Muhammad Hisyamudin 
Published: March 2021

AbstractThe use of information technology is widespread across various sectors. However, technology usage is sometime declining among certain individuals, and it is a drawback because the technology is not completely utilized. This study proposed that performance expectancy will have a relationship with user continuance intention. We use validated instrument obtained from previous study. Data was collected from 315 undergraduate and post graduate students from Malaysian private higher learning institution. The software SPSS 22 was adopted to analyse the proposed model. Statistical results demonstrated that performance expectancy is a strong predictor of user continuance intention. Implications for practitioners based on the results were discussed.
Measurement model for e-campus acceptance: A study in semi-private higher institutions in Malaysia
Authors: Halim Nor Fatiha binti Abdul , Anuar Nik Nur Nabihan Nik , Razak Fahmi Zaidi Abdul 
Published: March 2021

Abstract
Previous efforts to validate instruments to measure constructs related to technology acceptance have been very successful. However, little is known of its validity in private higher learning institution especially in religious based institution. We present an established and validated instrument to be revalidated in religious based higher learning institution. The scale involved in this validation study is technical proficiency, computer anxiety, satisfaction and innovativeness. Findings indicates that all subscale demonstrated adequate reliability and validity. Implications for future research are discussed.
Analytical Hierarchical Process (AHP): statistical index and factors that influence the housing price in Kuala Lumpur
Authors: Yee Gan Fui , Sufahani Suliadi Firdaus , Wahab Mohd Helmy Abd , Idrus Syed Zulkarnain Syed 
Published: March 2021

Abstract
The housing affordability issue has seriously occurred in Kuala Lumpur recently as the property price increased significantly from time to time. Several factors may influence the decision making of the buyers. The factors were the interesting topic for this study which can assist the consumers to purchase a suitable residence in Kuala Lumpur. The Analytical Hierarchical Process (AHP) was used to determine the best alternative for the housing selection. The priority weight for seven factors were determined and the AHP structure simultaneously. As the result showed, the best alternative is the medium property price where the consumer should purchase a residential property with medium property price. This research may limit to the opinions of the consumers, the recommendation for further researchers was to gather more thoughts from the policymaker or the developer to understand the overall situation for this issue.