bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable business model for local council’s smart city initiatives: a systematic literature review
Authors: Mustaffa Kamal Effendee Ezatul Faizura , Dorasamy Magiswary , Bin Ahmad Abdul Aziz , Aris Azrin , Harguem Saida , Kaliannan Maniam 
Published: October 2021

Background: Malaysia is embarking on sustainable, resilient, and prosperous living conditions initiatives. Malaysian cities are embracing the smart city aspiration through their respective local authorities. However, they face challenges regarding funding allocation for smart city implementation. Local authorities primarily operate on a conventional business model. Based on their current business model, they are unlikely to sustain their smart city initiatives. A more financially sustainable business model is required by these local authorities to embark on smart city initiatives. This study presents a systematic review concerning the business models adopted by local authorities to implement smart cities. This paper also explores the applicability of frugal innovation towards developing a smart city business model. Methods: This article undertakes a systematic review based on combination sets of eight main keywords: smart city, business model, frugal innovation, local authorities, performance, inclusivity, technology and success factor. The search strategy includes journal articles and conference proceedings from five major online databases: Emerald, ProQuest, Scopus, IEEE Xplore, ScienceDirect, and Springer Link between 2001-2021. The data is tabulated for clear expression of knowledge gaps. Results: A total of 17 articles from 300 articles on smart city business models matched the search on smart city business models for local authorities . The study revealed that hardly any in-depth research providing the crucial elements for a successful smart city business model for local authorities has been conducted. No research has linked frugal innovation to smart city business models. Conclusions: The study calls upon the research community to explore further, the possible linkage between frugal innovation and smart cities for local authorities.
Testing for sensory threshold in drinking water with added calcium: a first step towards developing a calcium fortified water
Authors: Cormick Gabriela , Matamoros Natalia , Romero Iris B. , Perez Surya M. , White Cintia , Watson Dana Z. , Belizán José M. , Sosa Miriam , Gugole Ottaviano M. Fernanda , Elizagoyen Eliana , Garitta Lorena 
Published: October 2021

Background: Food fortification is an effective strategy that has been recommended for improving population calcium inadequate intakes. Increasing calcium concentration of water has been proposed as a possible strategy to improve calcium intake. The objective of this study was to determine the sensory threshold of different calcium salts added to drinking water using survival analysis. Methods: We performed the triangle test methodology for samples of water with added calcium using three different calcium salts: calcium chloride, calcium gluconate and calcium lactate. For each salt, a panel of 54 consumers tested seven batches of three water samples. Data were adjusted for chance and sensory threshold was estimated using the survival methodology and a discrimination of 50%. Results: The threshold value estimation for calcium gluconate was 587 ± 131 mg/L of water, corresponding to 25% discrimination, for calcium lactate was 676 ± 186 mg/L, corresponding to 50% discrimination, and for calcium chloride was 291 ± 73 mg/L, corresponding to 50% discrimination. Conclusions: These results show that water with calcium added in different salts and up to a concentration of 500 mg of calcium/L of water is feasible. The calcium salt allowing the highest calcium concentration with the lowest perceived changes in taste was calcium gluconate. Future studies need to explore stability and acceptability over longer periods of time.
Basic taste sensitivity, eating behaviour, and propensity of dairy foods of preadolescent children: How are they related?
Authors: Ervina Ervina , Berget Ingunn , Skeie Siv Borghild , L. Almli Valérie 
Published: October 2021

Background: Taste sensitivity has been reported to influence children’s eating behaviour and contribute to their food preferences and intake. This study aimed to investigate the associations between taste sensitivity and eating behaviour in preadolescents. Methods: Children’s taste sensitivity was measured by detection threshold with five different concentration levels of sweetness (sucrose), sourness (citric acid), saltiness (sodium chloride), bitterness (caffeine, quinine), and umami (monosodium glutamate). In addition, the Child Eating Behaviour Questionnaire (CEBQ), the Food Propensity Questionnaire (FPQ), and the children’s body weight and height were completed by the parents. Children conducted the sensory evaluation test at schools while parents completed the questionnaires online. Results: A total of 69 child-parent dyads participated. Taste sensitivity was significantly associated with eating behaviour in food responsiveness, emotional overeating, and desire to drink. Children who were less sensitive to caffeine bitterness (higher detection threshold) had higher food responsiveness scores, while those who were less sensitive to sweetness and caffeine bitterness had higher emotional overeating scores. In addition, children who were less sensitive to sourness and bitterness of both caffeine and quinine demonstrated to have higher scores in desire to drink. There was no association between taste sensitivity and FPQ, but significant differences were observed across children’s body mass index (BMI) regarding their FPQ of dairy food items, indicating higher consumption of low-fat milk in the overweight/obese compared to the normal-weight subjects. There was no significant difference in taste sensitivity according to BMI. Children’s eating behaviour differed across BMI, demonstrating a positive association between BMI and food approach, and a negative association between BMI and food avoidance. Conclusions: This study contributes to the preliminary understanding of the relationships between taste sensitivity and eating behaviour in preadolescents which could be used to develop effective strategies to promote healthy eating practices in children by considering their taste sensitivity.
Rapid evidence review to inform safe return to campus in the context of coronavirus disease 2019 (COVID-19)
Authors: Greenhalgh Trisha , Katzourakis Aris , Wyatt Tristram D. , Griffin Stephen 
Published: October 2021

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted predominantly through the air in crowded and unventilated indoor spaces among unvaccinated people. Universities and colleges are potential settings for its spread. Methods: An interdisciplinary team from public health, virology, and biology used narrative methods to summarise and synthesise evidence on key control measures, taking account of mode of transmission. Results: Evidence from a wide range of primary studies supports six measures. Vaccinate (aim for > 90% coverage and make it easy to get a jab). Require masks indoors, especially in crowded settings. If everyone wears well-fitting cloth masks, source control will be high, but for maximum self-protection, respirator masks should be worn. Masks should not be removed for speaking or singing. Space people out by physical distancing (but there is no “safe” distance because transmission risk varies with factors such as ventilation, activity levels and crowding), reducing class size (including offering blended learning), and cohorting (students remain in small groups with no cross-mixing). Clean indoor air using engineering controls—ventilation (while monitoring CO2 levels), inbuilt filtration systems, or portable air cleaners fitted with high efficiency particulate air [HEPA] filters). Test asymptomatic staff and students using lateral flow tests, with tracing and isolating infectious cases when incidence of coronavirus disease 2019 (COVID-19) is high. Support clinically vulnerable people to work remotely. There is no direct evidence to support hand sanitising, fomite controls or temperature-taking. There is evidence that freestanding plastic screens, face visors and electronic air-cleaning systems are ineffective. Conclusions: The above six evidence-based measures should be combined into a multi-faceted strategy to maximise both student safety and the continuation of in-person and online education provision. Staff and students seeking to negotiate a safe working and learning environment should collect data (e.g. CO2 levels, room occupancy) to inform conversations.
Biomechanics of anatomic and reverse shoulder arthroplasty
Authors: Goetti Patrick , Denard Patrick J. , Collin Philippe , Ibrahim Mohamed , Mazzolari Adrien , Lädermann Alexandre 
Published: October 2021

The biomechanics of the shoulder relies on careful balancing between stability and mobility. A thorough understanding of normal and degenerative shoulder anatomy is necessary, as the goal of anatomic total shoulder arthroplasty is to reproduce premorbid shoulder kinematics. With reported joint reaction forces up to 2.4 times bodyweight, failure to restore anatomy and therefore provide a stable fulcrum will result in early implant failure secondary to glenoid loosening. The high variability of proximal humeral anatomy can be addressed with modular stems or stemless humeral components. The development of three-dimensional planning has led to a better understanding of the complex nature of glenoid bone deformity in eccentric osteoarthritis. The treatment of cuff tear arthropathy patients was revolutionized by the arrival of Grammont’s reverse shoulder arthroplasty. The initial design medialized the centre of rotation and distalized the humerus, allowing up to a 42% increase in the deltoid moment arm. More modern reverse designs have maintained the element of restored stability but sought a more anatomic postoperative position to minimize complications and maximize rotational range of motion. Cite this article: EFORT Open Rev 2021;6:918-931. DOI: 10.1302/2058-5241.6.210014
Surgical risk factors associated with the development of adjacent segment pathology in the lumbar spine
Authors: Pinto Eduardo Moreira , Teixeira Artur , Frada Ricardo , Atilano Pedro , Miranda António 
Published: October 2021

Adjacent segment pathology (ASP) is a major cause of disability, and the recognition of the surgical risk factors associated with the development of this condition is essential for its prevention. Different surgical approaches, from decompression without fusion to non-instrumented and instrumented fusion, have distinct contributions to the development of ASP. Although motion-preservation procedures could reduce the prevalence of ASP, these are also associated with a higher percentage of complications. Several risk factors associated with previous surgery, namely the chosen surgical approach and anatomical dissection, the choice of interbody fusion, the increment and length of the fusion, and the restoration of sagittal alignment, may influence the development of ASP. Cite this article: EFORT Open Rev 2021;6:966-972. DOI: 10.1302/2058-5241.6.210050
Surface bone sarcomas: an update on current clinicopathological diagnosis and treatment
Authors: Savvidou Olga , Papakonstantinou Olympia , Lakiotaki Eleftheria , Zafeiris Ioannis , Melissaridou Dimitra , Korkolopoulou Pinelopi , Papagelopoulos Panayiotis J. 
Published: October 2021

Surface bone sarcomas are rare malignant bone tumours. Osseous and cartilaginous surface bone sarcomas are the most common, with parosteal and periosteal osteosarcomas, periosteal chondrosarcomas and secondary peripheral chondrosarcomas being the most frequent. Their clinical symptoms are non-specific and include pain for several months, swelling and limited range of motion of the adjacent joints. Prompt diagnosis is important, as biological behaviour, imaging and histopathologic characteristics, treatment and prognosis differ considerably from their conventional intramedullary counterparts. Moreover, their imaging characteristics are not infrequently non-characteristic and may be misinterpreted as juxtacortical benign lesions leading to incorrect diagnosis and treatment, with life-threatening repercussions. Molecular studies and histopathological sampling are essential for accurate diagnosis. There are still numerous issues regarding the biology, pathophysiology and treatment options of these entities due to their rarity.Cite this article: EFORT Open Rev 2021;6:905-917. DOI: 10.1302/2058-5241.6.210064
Photosynthetic spectral response curves of saffron leaves
Authors: Ji Xinyu , Gao Dan , Pei Weizhong , Zhang Xue , Li Fusheng , Han Qiuyi , Zhang Shanduan 
Published: October 2021

Saffron (Crocus sativusL.) is an herb with outstanding medicinal functions and commercial value. Light is an important factor in plant growth, and the sensitivity of plant photosynthesis to light quality can be characterized by photosynthetic spectral response curves. This study aims to measure the spectral response curves of saffron leaves so as to provide theoretical guidance for a supplemental lighting spectrum to increase saffron production. The measurement results show the peaks of spectral response curves of saffron leaves are at 480 nm and 660 nm, which provides a reference for the peak wavelengths of supplemental lighting spectrum. Full-spectrum white light with low color temperature or red light mixed with a little blue light might be most beneficial for saffron biomass accumulation.
Generic zoledronic acid for osteoporosis: focus on tolerability and safety
Authors: Toroptsova N. V. , Efremova A. O. , Korotkova T. A. , Dobrovolskaya O. V. , Feklistov A. Yu. 
Published: October 2021

Objective: assessment of safety and tolerability of a new generic drug of zoledronic acid (Osteostatics) in patients.Patients and methods. Clinical observation included 30 postmenopausal women aged 45 years and older (mean age 64±8 years). To determine the safety of the drug of zoledronic acid, all patients underwent biochemical blood test; to assess the tolerability, adverse effects (AE) associated with the administration of the drug were recorded. Fractures that may have occurred during follow-up were also required to be recorded as AE.Results and discussion. AE was reported by 15 (50.0%) patients. In 13 (43.3%) of them flu-like syndrome (FLS) was noted, including 12 with an increase in body temperature on average to 38.4 [38.0; 38.6] ° C, in 1 (7.7%) – with abdominal pain and nausea, 5 (38.5%) women noted myalgia and/or arthralgia, and 2 (15.4%) – redness and pain in the eyes. In patients who had not previously received bisphosphonate (BP) therapy, AEs were recorded in 62.5% of cases, and in those who had already received such treatment in 15.4%. In most cases, AEs occurred in the first 48 hours, and their duration averaged 2 days.Conclusion. The incidence of AE was 50.0%, which did not exceed that when using the original zoledronic acid in real clinical practice. The majority of AEs occurred in “naive” patients, developed in the first 2 days after drug administration, and resolved on average within the next 2 days.
Ten Simples Rules on How to Organise a Bioinformatics Hackathon
Authors: Hollmann Susanne , Regierer Babette , Attwood Teresa K , Gisel Andreas , Van Helden Jacques , Rossier Gregoire , Kersey Paul J , Korpelainen Eija , Vriend Gert , Bongcam-Rudloff Erik 
Published: October 2021

The completion of the human genome sequence triggered worldwide efforts to unravel the secrets hidden in its deceptively simple code. Numerous bioinformatics projects were undertaken to hunt for genes, predict their protein products, function and post-translational modifications, analyse protein-protein interactions, etc. Many novel analytic and predictive computer programmes fully optimised for manipulating human genome sequence data have been developed, whereas considerably less effort has been invested in exploring the many thousands of other available genomes, from unicellular organisms to plants and non-human animals. Nevertheless, a detailed understanding of these organisms can have a significant impact on human health and well-being.New advances in genome sequencing technologies, bioinformatics, automation, artificial intelligence, etc., enable us to extend the reach of genomic research to all organisms. To this aim gather, develop and implement new bioinformatics solutions (usually in the form of software) is pivotal. A helpful model, often used by the bioinformatics community, is the so-called hackathon. These are events when all stakeholders beyond their disciplines work together creatively to solve a problem. During its runtime, the consortium of the EU-funded project AllBio - Broadening the Bioinformatics Infrastructure to cellular, animal and plant science - conducted many successful hackathons with researchers from different Life Science areas. Based on this experience, in the following, the authors present a step-by-step and standardised workflow explaining how to organise a bioinformatics hackathon to develop software solutions to biological problems.
Small double limit with reflecting Wentzel boundary condition
Authors: Sane Ibrahima , Diedhiou Alassane 
Published: October 2021

Abstract
We provide a large deviation principle on the stochastic differential equations with reflecting Wentzel boundary condition if

δ
ε

{\frac{\delta}{\varepsilon}}

tends to 0 when the two parameters δ (homogenization parameter) and ε (the large deviations parameter) tend to zero. Here, we suppose that the homogenization parameter converges sufficiently quickly more than the large deviations parameter. Furthermore, we will make explicit the associated rate function.
A simple closed-form model to accurately calculate the electromechanical coupling coefficient of CMUTs
Authors: Chowdhury Sazzadur 
Published: October 2021

Abstract
A simple highly accurate closed-form model to calculate the electromechanical coupling coefficient of a capacitive micromachined ultrasonic transducer (CMUT) is presented. The model exploits the electrostatic spring softening phenomenon to derive an expression for the energy converted from electrical to mechanical domain and includes the nonlinear change of the CMUT diaphragm stiffness during large deflections. The model has been validated by comparing the model predicted values with experimental results published elsewhere along with the results predicted by some existing models. The comparison shows that the model predicted values are in excellent agreement with experimental results. The model also enables one to quantify the effects of residual stress, bending, and nonlinear stretching of the diaphragm on the transduction efficiency of CMUTs without any computationally intensive finite element analysis method. The model resolves the ambiguity of the absence of electrostatic spring softening effect in some existing models.
Measurement Agreement Between Samozino's Method and Force Plate Force-Velocity Profiles During Barbell and Hexbar Countermovement Jumps
Authors: Hicks Dylan S. , Drummond Claire , Williams Kym J. 
Published: October 2021

Abstract
Hicks, DS, Drummond, C, and Williams, KJ. Measurement agreement between Samozino's method and force plate force-velocity profiles during barbell and hexbar countermovement jumps. J Strength Cond Res 36(12): 3290–3300, 2022—This study aimed to measure agreement between using Samozino's method and force plates to determine mean force, velocity, and power during unloaded and loaded barbell and hexbar countermovement jumps. Twenty-one subjects performed countermovement jumps against incremental loads using both loading conditions. Ground reaction force was recorded using a dual-force plate system (1,000 Hz) and used as the criterion method to compare with Samozino's method. Reliability and validity was determined by intraclass correlation coefficients (ICCs), coefficient of variation (CV), limits of agreement plots, and least products regression analysis. Samozino's method provided acceptable levels of reliability for mean force, velocity, and power (ICC > 0.90, CV% < 5.5) across both loading conditions. Limits of agreement analysis showed the mean bias was 2.7, 15.4, and 7.2% during barbell countermovement jumps and 1.8, 12.4, and 5.0% during hexbar countermovement jumps for mean force, velocity, and power, respectively. Based on these findings, Samozino's method not only is reliable when measuring mean force, velocity, and power during loaded and unloaded barbell and hexbar countermovement jumps but also identifies limitations regarding concurrent validity compared with the gold standard. Across loading conditions, Samozino's method overestimated mean force (0.5–4.5%) and underestimated mean velocity (11.81–16.78%) and mean power (2.26–7.85%) compared with the force plates. Because of fixed and proportional bias between criterion and predictor, the results do not support the use of Samozino's method to measure mean force, velocity, and power. Therefore, it is not recommended for practitioners to use Samozino's method to estimate mechanical variables during loaded and unloaded countermovement jump actions using a barbell and hexbar.
Medial Entorhinal Cortex Excitatory Neurons Are Necessary for Accurate Timing
Authors: Dias Marcelo , Ferreira Raquel , Remondes Miguel 
Published: October 2021

The hippocampal region has long been considered critical for memory of time, and recent evidence shows that network operations and single-unit activity in the hippocampus and medial entorhinal cortex (MEC) correlate with elapsed time. However, whether MEC activity is necessary for timing remains largely unknown. Here we expressed DREADDs (designer receptors exclusively activated by designer drugs) under the CaMKIIa promoter to preferentially target MEC excitatory neurons for chemogenetic silencing, while freely moving male rats reproduced a memorized time interval by waiting inside a region of interest. We found that such silencing impaired the reproduction of the memorized interval and led to an overestimation of elapsed time. Trial history analyses under this condition revealed a reduced influence of previous trials on current waiting times, suggesting an impairment in maintaining temporal memories across trials. Moreover, using GLM (logistic regression), we show that decoding behavioral performance from preceding waiting times was significantly compromised when MEC was silenced. In addition to revealing an important role of MEC excitatory neurons for timing behavior, our results raise the possibility that these neurons contribute to such behavior by holding temporal information across trials.SIGNIFICANCE STATEMENTMedial temporal lobe (MTL) structures are implicated in processing temporal information. However, little is known about the role MTL structures, such as the hippocampus and the entorhinal cortex, play in perceiving or reproducing temporal intervals. By chemogenetically silencing medial entorhinal cortex (MEC) excitatory activity during a timing task, we show that this structure is necessary for the accurate reproduction of temporal intervals. Furthermore, trial history analyses suggest that silencing MEC disrupts memory mechanisms during timing. Together, these results suggest that MEC is necessary for timing behavior, possibly by representing the target interval in memory.