bluuebunny/crossref_metadata_2025_split huggingface dataset:
First Worldwide Slim Coiled-Tubing Logging Tractor Deployment
Authors: Duthie Laurie , Saiood Hussain , Anizi Abdulaziz , Moore Bruce 
Published: October 2021

Summary
Successful reservoir surveillance and production monitoring is a key component for effectively managing any field production strategy. For production logging in openhole horizontal extended reach wells (ERWs), the challenges are formidable and extensive; logging these extreme lengths in a cased hole would be difficult enough but is considerably exaggerated in the openhole condition. A coiled-tubing (CT) logging run in open hole must also contend with increased frictional forces, high dogleg severity, a quicker onset of helical buckling, and early lockup. The challenge of effectively logging these ERWs is further complicated by constraints in the completion where electrical submersible pumps (ESPs) are installed, including a 2.4-in. bypass section.
Although hydraulically powered CT tractors already existed, a slim CT tractor with real-time logging capabilities was not available in the market. In partnership with a specialist CT tractor manufacturer, a slim logging CT tractor was designed and built to meet the exceptional demands of pulling the CT to target depth (TD). The tractor is 100% hydraulically powered, with no electrical power, allowing for uninterrupted logging during tractoring. The tractor is powered by the differential pressure from the bore of the CT to the wellbore and is operated by a preset pump rate from surface.
Developed to improve the low coverage in openhole ERW logging jobs, the tractor underwent extensive factory testing before being deployed to the field. The tractor was rigged up on location with the production logging tool and run in hole (RIH). Once the CT locked up, the tractor was activated and pulled the coil to cover more than 90% of the openhole section, delivering a pulling force of up to 3,200 lbf. Real-time production logging was conducted simultaneously with the tractor activation; flowing and shut-in passes were completed to successfully capture the zonal inflow profile. Real-time logging with the tractor is logistically efficient and allows instantaneous decision making to repeat passes for improved data quality.
The new slim logging tractor (SLT) is the world’s slimmest and most compact and is the first CT tractor of its kind to enable production logging operations in openhole horizontal ERWs. The importance of the ability to successfully log these ERWs cannot be overstated; reservoir simulations and management decisions are only as good as the quality of data available. Some of the advantages of drilling ERWs, such as increased reservoir contact, reduced footprint, and fewer wells drilled, will be lost if sufficient reservoir surveillance cannot be achieved. To maximize the benefits of ERWs, creative solutions and innovative designs must be developed continually to push the boundaries further.
Population Genetics and Evolution Analysis Reveal Diversity and Origin of Ammopiptanthus in China
Authors: Chai Guaiqiang , Duan Yizhong , Jiao Peipei , Du Zhongyu , Kang Furen 
Published: October 2021

Abstract
Background
Elucidating and revealing the population genetic structure, genetic diversity and recombination is essential for understanding the evolution and adaptation of species. Ammopiptanthus, which is an endangered survivor from the Tethys in the Tertiary Period, is the only evergreen broadleaf shrub grown in Northwest of China. However, little is known about its genetic diversity and underlying adaptation mechanisms.
Results
Here, 111 Ammopiptanthus individuals collected from fifteen natural populations in estern China were analyzed by means of the specific locus amplified fragment sequencing (SLAF-seq). Based on the single nucleotide polymorphisms (SNPs) and insertions and deletions (InDels) detected by SLAF-seq, genetic diversity and markers associated with climate and geographical distribution variables were identified. The results of genetic diversity and genetic differentiation revealed that all fifteen populations showed medium genetic diversity, with PIC values ranging from 0.1648 to 0.3081. AMOVA and Fst indicated that a low genetic differentiation existed among populations. Phylogenetic analysis showed that NX-BG and NMG-DQH of fifteen populations have the highest homology,while the genetic structure analysis revealed that these Ammopiptanthus germplasm accessions were structured primarily along the basis of their geographic collection, and that an extensive admixture occurred in each group. In addition, the genome-wide linkage disequilibrium (LD) and principal component analysis showed that Ammopiptanthus nanus had a more diverse genomic background, and all genetic populations were clearly distinguished, although different degrees of introgression were detected in these groups.
Conclusion
Our study could provide guidance to the future design of association studies and the systematic utilization and protection of the genetic variation characterizing the Ammopiptanthus.
Glutathione peroxidase 3 (GPX3) expression predicts the prognosis of numerous malignant tumors: A pan-cancer Analysis
Authors: Wang Yuetong , Fu Guotao , Chen Xueqin , Xia Zengrun , Qi Meng , Du Xiaoping , Liu Kun , Liu Qiling , Sun Na , Shi Chuandao , Zhang Rongqiang , Qu Kai 
Published: October 2021

Abstract
Background
Malignant tumor is a general term for uncontrollable growth of cells. Several studies have investigated that role of GPX3 in tumors. However, no pan-cancer analysis has be conducted to assess the diagnostic and prognostic potential of GPX3.
Methods
GPX3 mRNA and protein expression profile was analyzed in the TCGA + GTEx database and CPTAC database. Kaplan-Meier survival curves and forest plots were constructed to help evaluate the impact of GPX3 on the survival and prognosis of cancer patients. Gene mutations of GPX3 were analyzed based on TMB/MSI. The correlation between GPX3 and tumor immune infiltration was assessed using TIMER2. Enrichment analysis was performed to determine tumor-related signaling pathways associated with GPX3. A prediction model for STAD was established.
Results
GPX3 was downregulated in most malignant tumors, and was significantly associated with the survival and prognosis of malignant tumors, such as STAD, PAAD, COAD, etc. Moreover, GPX3 expression was positively correlated and negatively with MSI in 13 and 20 categories of tumor respectively after GPX3 expression was positively correlated and negatively with TMB in 9 and 24 tumors separately (P < 0.05). A positive correlation was found between GPX3 and the infiltration level of major immune cells and Cancer-associated fibroblasts (P < 0.05). The effects of GPX3 were mediated by the AMPK signaling pathway, fructose and mannose metabolism.
Conclusions
This is a novel pan-cancer analysis on the relationship between GPX3 and human tumors. Findings of this research will deepen our understanding on the role of GPX3 in the development, regulation and prognosis of malignant tumors.
Dexmedetomidine Induces Low Patient State Indices While Preventing the Development of Postoperative Delirium in Older Patients Undergoing General Anesthesia - A Secondary Analysis of a Randomized Controlled Trial (NEUPRODEX)
Authors: Thomas Juliane , Koch Susanne , Spies Claudia D , Liederwald Leonie , Pohrt Anne , Mueller Anika 
Published: October 2021

Abstract
Background: Dexmedetomidine may have a delirium preventive effect in high-risk surgical patients. Accurate frontal EEG-guided anesthesia can decrease the incidence of postoperative delirium by avoiding too deep anesthesia. Aim of our study is to evaluate the incidence of postoperative delirium under intraoperative frontal EEG neuromonitoring during general anesthesia with dexmedetomidine.Methods: A secondary analysis of a single-center, randomized, double-blinded, placebo-controlled trial. Patients > 60 years were included with either abdominal or cardiac surgery, receiving intraoperative dexmedetomidine or placebo. Delirium incidence was measured up to the fifth postoperative day. Anesthetic depth was measured as Patient State Index (PSi™) every 15 minutes during surgery using EEG-based neuromonitoring.Results: Of the 60 patients included, the incidence of postoperative delirium was significantly reduced in the dexmedetomidine group (n=28) vs. the control group (n=32) (p=0.031). A PSi less than 25 at least once was seen in 85.2% of the verum group and 58.1% of the placebo group (p=0.024). The mean (SD) PSi value in the dexmedetomidine group was 28.17 (10.35) and 33.55 (11.31) in the placebo group using mixed-model ANOVA.Conclusions: Intraoperative Dexmedetomidine reduces the incidence of postoperative delirium in older patients at risk, although presenting with lower intraoperative PSi levels.
Lentivector cryptic splicing mediates increase in CD34+ clones expressing truncated HMGA2 in human SCID-X1
Authors: De Ravin Suk See , Liu Siyuan , Sweeney Colin , Brault Julie , Whiting-Theobald Narda , Ma Michelle , Choi Uimook , Lee Janet , Anaya-O'Brien Sandra , Quackenbush Priscilla , Estwick Tyra , Karra Anita , Kwatemaa Nana , Guo Shuang , Su Ling , sun David , Zhou Sheng , Malech Harry , Wu Xiaolin , Liu Taylor 
Published: October 2021

Abstract
A 4–8 year follow-up of vector integration site (VIS) analysis in blood lineages from patients with X-linked severe combined immune deficiency receiving lentivector gene therapy found a > 60-fold increase in frequency of forward-orientated VIS within intron 3 of HMGA2. Some patients demonstrated emergence of dominant HMGA2 VIS clones in progenitor and myeloid lineages, but with no disturbance of hematopoiesis. Molecular analysis demonstrated a cryptic splice site within the cHS4 insulator generating truncated mRNA transcripts from any transcriptionally active gene containing forward-oriented intronic insert, but with detectable effect on VIS frequency only for intron 3 HGMA2 inserts. A two base-pair change at the splice site eliminated splicing activity while retaining vector functional capability. Functional analysis of lentivectors for cryptic splicing should become routine for pre-clinical safety assessment.
Reduction of testosterone levels in Schistosoma haematobium- or Schistosoma mansoni-infected men: a cross-sectional study in two schistosomiasis-endemic areas of the Adamawa region of Cameroon
Authors: JATSA Hermine BOUKENG , FEMOE Ulrich MEMBE , DONGMO Calvine NOUMEDEM , KAMWA Romuald Issiaka NGASSAM , FESUH Betrand NONO , TCHUENTE Louis-Albert TCHUEM , KAMTCHOUING Pierre 
Published: October 2021

Abstract
Background: The incidence of schistosomiasis‐induced male reproductive dysfunction and infertility is probably underestimated compared to female genital schistosomiasis. This study aimed to investigate the impact of S. haematobium or S. mansoni infection on the reproductive function of adult men in Tibati and Wouldé, two schistosomiasis endemic areas in the Adamawa region of Cameroon.Methods: A total of 89 men of reproductive age (range: 14 – 56 years) from two localities were enrolled in the study, with 51 in Tibati and 38 in Wouldé. Each participant was submitted to a questionnaire to document data on sociodemographic and stream contact behaviors. A medical examination was performed to measure the circumference of the testes and to evaluate genital tract pathologies. Stool and urine samples were collected and screened for the presence of S. haematobium or S. mansoni ova. Blood serum was used to evaluate the levels of transaminases and testosterone.Results: S. haematobium was present only in Tibati, with a prevalence of 31.37%. The S. mansoni prevalence was 3.92% at Tibati and 44.71% in Wouldé. The intensity of infection was 22.12 ± 9.57 eggs/10 mL for S. haematobium and 128.10 ± 3.76 epg for S. mansoni. Serum transaminase activity and the mean testicular circumference of Schistosoma-positive individuals were close to those of Schistosoma-negative individuals. However, the testes size was higher in S. mansoni-positive individuals than in S. haematobium-positive individuals (P < 0.05). The serum testosterone levels of S. haematobium- and S. mansoni-positive men were significantly reduced by 56.07% (P < 0.001) and 51.94% (P < 0.01), respectively, in comparison to those of Schistosoma-negative men. A significant and negative correlation was established between schistosomiasis and the low level of serum testosterone. Male genital tract pathologies such as scrotal abnormalities, varicocele, nodular epididymis, inguinal hernia and hydrocele were recorded in both Schistosoma-positive and Schistosoma-negative men. However, no significant link was established between schistosomiasis infection and these pathologies.Conclusion: These results demonstrated that infection with S. haematobium or S. mansoni is associated with low production of the reproductive hormone testosterone and may be a major cause of male infertility.
Temperature-Dependent Viscosity and Nanoparticle Effect on Wire Coating Using Third-Grade As a Polymer Liquid With Magnetic Field Flow Within Porous Die
Authors: Khan Zeeshan , Khan Prof. Dr. Ilyas 
Published: October 2021

Abstract
The convective heat and mass propagation inside dies are used to determine the characteristics of coated wire products. As a result, comprehending the properties of polymerization mobility, heat mass transport, and wall stress concentration is crucial. The wire coating procedure necessitates an increase in thermal performance. As a result, this research aims to determine how floating nanoparticles affect the mass and heat transport mechanisms of third-grade fluid in the posttreatment for cable coating processes. For nanoﬂuids, the Buongiorno model is used, including variable viscosity. The model equations are developed using continuity, momentum, energy, and nanoparticle volume fraction concentration. We propose a few nondimensional transformations that are relevant. The numerical technique Runge-Kutta fourth method is used to generate numerical solutions for nonlinear systems. Pictorial depictions are used to observe the influence of various factors in the nondimensional flow, radiative, and nanoparticle concentration fields. Furthermore, the numerical results are also verified analytically using Homotopy Analysis Method (HAM). The analytical findings of this investigation revealed that within the Reynolds modeling, the stress on the whole wire surface combined with shear forces at the surface predominates Vogel's model. The contribution of nanomaterials upon force on the entire surface of wire and shear forces at the surface appears positive. A non-Newtonian feature can increase the capping substance's velocity. This research could aid in the advancement of wire coating technologies.For the first instance, the significance of nanotechnology during wire coating evaluation is explored utilizing Brownian motion with generation/absorption slip processes. For time-dependent viscosity, two alternative models are useful.
The Seasonal Variation Characteristics and Influencing Factors of Soil Ecological Stoichiometry with Different Land Use Types in Karst Rocky Desertification Area in Southwest China
Authors: Chi Yongkuan , Song Shuzhen , Xiong Kangning 
Published: October 2021

Abstract
Aims Study the influence of different land use types on the stoichiometric characteristics of soil C, N, P, and explore its response to environmental factors. Methods The research takes soils of 6 different land use types (shrub grassland, dry land, economic fruit forest, sparse forest, primary forest, and waste grassland) from the demonstration area for ​​comprehensive control of karst rocky desertification in southwest China-Grand Canyon of Guanling Huajiang, Guizhou as the research object. Results The result shows that the C, N, and P contents of primary forest among the six different land use types are the highest, which are significantly higher than that of shrub grassland, dry land, economic fruit forest, and waste grassland. The C and N contents of waste grassland are the lowest, which are significantly lower than that of primary forest, sparse forest and shrub grassland, roughly represented as primary forest>sparse forest>shrub grassland>dry land>economic fruit forest>waste grassland. The C, N, and P contents show certain seasonal variations, which are higher in autumn than in spring. In addition, soil C, N, and P contents show a trend of decreasing with the increase of soil layer thickness, with obvious surface accumulation characteristics. Conclusions The soil C:N of spring and autumn in 6 different land use types are lower than the national and global averages, and the C:P and N:P are much higher than the average value of karst soils in the same area, indicating that the soil in the study area is relatively sufficient in N but P is relatively lacking. Redundancy analysis shows that soil C, N and P in different land use types are affected. The main environmental factors for the change of stoichiometric characteristics are the human activity intensity, landform, and the slope. The research results will provide relevant theoretical support for the control of rocky desertification and vegetation restoration in southwest karst.
Endoscopic Scoring System for Gastric Atrophy and Intestinal Metaplasia: Correlation with OLGA and OLGIM Staging: A Single Center Prospective Pilot Study
Authors: Na Hee Kyong , Choi Kee Don , Park Young Soo , Kim Hwa Jung , Ahn Ji Yong , Lee Jeong Hoon , Jung Kee Wook , Kim Do Hoon , Song Ho June , Lee Gin Hyug , Jung Hwoon-Yong 
Published: October 2021

Abstract
Background/Aims: We aimed to develop an endoscopic scoring system to evaluate atrophic and intestinal metaplasia using narrow-band imaging (NBI) and near focus mode (NFM) to compare endoscopic scores with the Operative link for gastritis assessment (OLGA) and the Operative link for gastric intestinal metaplasia assessment (OLGIM). Methods: A total of 51 patients who underwent diagnostic esophagogastroduodenoscopy were prospectively enrolled and endoscopic scoring using NBI and NFM was performed. Four areas (the lesser and greater curvatures of the antrum and the lesser and greater curvature side of the corpus) were observed and biopsies were taken. The degree of atrophy was scored from 0 to 2 according to the Kimura-Takemoto classification (0: C0-1, 1: C2-3, 2: O1-3). The degree of metaplasia was scored from 0 to 4 (0: no metaplasia, 1: presence of metaplasia at the antrum, 2: presence of metaplasia at the corpus, add score 1: presence of metaplasia for 1/2> observed field of the picture at the antrum, add score 2: 1/2 > observed field of the picture at the corpus). The endoscopic scores were compared to the OLGA and OLGIM staging. Results: The correlation coefficient for atrophy between the endoscopic and histologic scores was 0.70 (95% CI: 0.52–0.81 p <0.001) and for metaplasia, it was 0.75 (95% CI: 0.60–0.85; p <0.001). For atrophic gastritis, endoscopic score > 1 correlated with OLGA stage III and IV with a sensitivity, specificity, positive predictive value, negative predictive value, and agreement of 88%, 74%, 75%, 87%, and 80.4%, respectively, and for metaplasia, an endoscopic score > 1 correlated with high OLGIM stage III and IV with 100%, 59%, 69%, 100%, and 78.4%, respectively. Conclusions: Endoscopic scoring for gastric atrophy and metaplasia using NBI-NFM correlate well with histologic staging.
Determinants of Under-Five Child Mortality in Iran: A Systematic Review
Authors: Abbasi Mahya , Tajvar Maryam , Karami Badrye 
Published: October 2021

Abstract
Background: The under-five child mortality is considered as one of the indicators of development and health of a population. The death of many children during this period is preventable. This study reviewed the determinants of child death in Iran.Methods: A systematic search in seven electronic databases and two search engines of all the studies that identified determinants of child mortality in any part of Iran or in the whole country were included, without any restriction of time or language of studies. To identify the studies, a combination of hand searching, gray literatures and bibliographies was also conducted. These sources and citations yielded a total of 512 articles; nevertheless, finally 32 articles fulﬁlled the inclusion criteria, then were reviewed and analyzed.Results: Amongst the 32 studies published between 2000 and 2019 in Iran, 22 studies were cross-sectional and 14 published in Farsi language. The associations between several factors (n=57) and the child mortality were examined. Factors such as ‘birth weight’, ‘mother’s literacy’, ‘socioeconomic status’, ‘delivery type’, ‘gestational age’, ‘pregnancy interval’, ‘place of residence’, ‘Immaturity’, ‘type of nutrition’, ‘father’s literacy’ and ‘child gender’ were the most important determinants of child mortality.Conclusions: Effective efforts with emphasis on identifying and managing the determinants of child mortality are essential to improve their health indicators.
Low color temperature artificial lighting can slow myopia development: long-term study using juvenile monkeys
Authors: Hu Yingzhou , Yang Hua , Li Hao , Lv Longbao , Wu Jing , Zhu Zhu , Zhang Yuhua , Yan Fang-Fang , Fan Shuhan , Wang Shuxiao , Zhao Jianping , Qi Qiang , Huang Changbing , Hu Xintian 
Published: October 2021

Abstract
The incidence of myopia has been increasing rapidly in recent decades, suggesting that environmental factors, such as light, may be a leading cause. Correlated color temperature (CCT) is a commonly used index to quantify the spectral composition of light. Here, we used 32 juvenile monkeys and selected four kinds of light with typical but different CCTs to study the relationship between CCT and ocular axial elongation. After half a year of observation, elongation of the ocular axis under low-CCT light was lower than that under high-CCT light. As excessive axial elongation is the main cause of juvenile myopia, these results provide a new approach for the prevention of juvenile myopia and establish a scientific foundation for introducing appropriate lighting standards in schools.
Title Page: Good medical adherence according to having meaning in life among Thai schizophrenic patients
Authors: Teetharatkul Teerapat , Pitanupong Jarurin 
Published: October 2021

Abstract
BackgroundThe narrative model was used to search for meaning in life, and to change the meaning of the illness for the taking of medication. This study aimed to explore medication adherence, meaning in life, and the association of medication adherence and meaning in life. MethodsThis cross-sectional study explored all Thai schizophrenic outpatients that followed up at the Psychiatric outpatient clinic, Songklanagarind Hospital. Three questionnaires were used:1) Demographic information 2) Medication adherence questionnaire 3) The meaning in life questionnaire. Descriptive statistics were calculated using proportions, median and inter-quartile range (IQR) or mean and standard deviation (S.D.). ResultsAccording to the study period, there were 110 respondents. Most of them (94.5%) came to regular follow-ups by doctors’ appointments. The majority of them were male (56.4%), single (76.4%), and Buddhist (82.7%). According to the medication adherence questionnaire, all participants (100%) had good medication adherence scores. Concerning meaning in life, most of the participants had high scores in all subparts of meaning in life. As a result, an attempt to indicate the association between good or poor medication adherence and meaning in life could not be established in this study. ConclusionsMost schizophrenic patients had good medication adherence as well as meaning in life. Thus, the narrative model helps patients to search for meaning in life; meaning in taking medications that decrease negative medication attitudes and change the meaning of the illness. Moreover, schizophrenia does not cause them suffering and it enables them to accept it as part of life.