bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Small Target Detection Research Based on Dynamic Convolution Neural Network
Authors: Bai Chenshuai , Wu Kaijun , Wang Dicong , Li Hong , Yan Mingjun , Huang Tao 
Published: September 2021

Abstract
Because the detection effect of EfficientNet-YOLOv3 target detection algorithm is not very good, this paper proposes a small target detection research based on dynamic convolution neural network. Firstly, the dynamic convolutional neural network is introduced to replace the traditional convolutional neural network, which makes the algorithm model more robust; Secondly, in the training process, the optimization parameters are continuously adjusted to further strengthen the model structure; Finally, in order to prevent over fitting, the Learning Rate and Batch Size parameters are modified during the training process. remote sensing image The results of the proposed algorithm on RSOD remote sensing image data sets show that compared with the original EfficientNet-YOLOv3 algorithm, the (Average Precision, AP) value is increased by 1.93% and the (Log Average Miss Rate ,LAMR) value is reduced by 0.0500; The results of the proposed algorithm on TGRS-HRRSD remote sensing image data set show that compared with the original EfficientNet-YOLOv3 algorithm, the mAP value is increased by 0.07% and the mLAMR value is reduced by 0.0007.
Exploration of a Metabolism-Related Gene Signature Predicting Prognosis for Ovarian Cancer
Authors: Zhang Jinling , Zhang Yifan , Zhang Lin , Li Haili 
Published: September 2021

Abstract
Background: Dysregulation of metabolism plays a critical role in the pathogenesis and progression of ovarian cancer (OC). However, the expression pattern of metabolic genes in OC and the prognostic value of metabolism-related genes for OC patients remains to be elucidated. Thus, this study aimed to identify a metabolism-related prognostic gene signature for OC. Methods: The expression profiles of metabolism-related genes and associated clinicopathological characteristics were obtained from online datasets (The Cancer Genome Atlas, TCGA and The Genotype-Tissue Expression, GTEx). The differently expressed genes were subjected to functional enrichment analysis. By means of LASSO, univariate and multivariate Cox regression analyses, this predictive signature was constructed and validated by internal and external databases. Genomic alterations, immune infiltration, tumor microenvironment, and drug sensitivity associated with the signature were also described.Results: A total of 302 metabolism-related differentially expressed genes were identified. These genes were mainly enriched in functions associated with substance and energy metabolism. Based on the 302 identified genes, a prognostic signature of 21 metabolic genes was constructed and validated across internal and external cohorts. The patients in the high-risk group had significantly longer overall survival compared to those in the low-risk group. By univariate and multivariate Cox regression, the signature was identified as an independent prognostic predictor for overall survival. There were also noticeable differences with regards to genetic alteration, immune infiltration, tumor microenvironment and drug sensitivity between the two groups.Conclusion: Our study suggests that clinical outcomes of OC patients are associated with dysregulated metabolic genes and that the metabolism-related prognostic signature can be used as a predictor for the overall survival of OC patients.
Quality of Life: Modified Triple-branched Stent Graft Implantation Versus Frozen Elephant Trunk Technique
Authors: Luo Zeng-Rong , Tang Mi-Rong , Li Jia-Hui , Chen Liang-Wan , Yan Liang-Liang 
Published: September 2021

Abstract
Objective: To compare the effects of modified triple-branched stent implantation and frozen elephant trunk technique on the quality of life (QoL) of acute Stanford Type A aortic dissection (AAAD) patients at different follow-up times.Methods: Data from 175 AAAD survivors was collected which were divided into two groups according to different surgical techniques: (group A): modified triple-branched stent graft implantation; (group B): frozen elephant trunk. The SF-36 were used to assess the QoL at discharge(AD), the third postoperative month (POM3), and the twelfth postoperative month (POM12).Results: (1)The total scores at each time of both groups showed lower than the normal level; Group A scored higher than group B at some time points in terms of some items (role physical, role emotion and mental health; all P=0.000), and some items at POM3 or POM12 scored higher than at discharge (role physical, social function; both P=0.000). (2) There were less patients with heavy self-perceived burden in group A than group B at discharge (P=0.032) and patients with heavy self-perceived burden decreased over time. (3) Young postoperative AAD patients (P=0.002) in group B (P=0.005) with heavy self-perceived burden (P=0.000) , acute renal failure (P=0.008) , long LOS (P=0.026) and blood loss（> 1000 mL / 24h）(P=0.039) seemed to get a worse QoL. Conclusion: The impact on QoL of the modified triple-branched stent graft implantation technique seemed to be better than those of frozen elephant trunk surgery in role physical, role emotion and mental health.
Improving the Elderly’s Mental Health by Using Public Open Spaces in Disadvantaged Urban Neighborhoods: Tehran, Iran
Authors: Lak Azadeh , Rashidghalam Parichehr 
Published: September 2021

Abstract
Background: Today, the beneficial impact of public open spaces(POS) on the mental and physical health of the elderly is considered worldwide. However, the knowledge about these effects on the mental health of older adults in disadvantaged urban neighborhoods, especially in developing countries, is still insufficient.Methods: This study investigates the relationship between POS use and the mental health status of elderly residents in the disadvantaged neighborhoods of Tehran, the capital of Iran. The data on the frequency of use of public open spaces and the health status include ten items collected from 420 older adults of disadvantaged neighborhoods in District 10 of Tehran. We used exploratory factor analysis to explore the main factors of the elderly mental health in the disadvantaged neighborhood. Finally, the multivariate multiple regression model was used to determine the relationship between the frequency of POS use and mental health status among older seniors.Results: These ten items identified two fundamental characteristics of mental health status, including “feeling worthless” and “social interaction,” using exploratory factor analysis. “Feeling of worthlessness” was negatively significantly associated with the level of gender, marital, occupation, and education, as well as frequently attending in POS. “Social interaction” was influenced by gender, occupation, and marital status, as well as frequent use of POS. The results showed that the frequency of public open space use has a negative correlation with the feeling of worthlessness and a positive correlation with the older residents’ social interactions and contacts.Conclusion: According to the findings, increasing the more senior residents’ access to public open spaces through planning can improve their mental health as well as their social interactions, especially in disadvantaged neighborhoods.
Nonhomogeneous Poisson Process Model of Summer High Temperature Extremes Over China
Authors: Gao Meng , Zhang Han , Zhang Aidi , Wang Yueqi 
Published: September 2021

Abstract
In this study, nonhomogeneous Poisson process (NHPP) models arising from the extreme value theory have been fitted to summer high temperature extremes (HTEs) at 359 meteorological stations over China. The seasonality and six prominent atmospheric teleconnection patterns in Northern Hemisphere are incorporated in the NHPP models reflecting the non-stationarity in occurrence rate in Poisson process of HTEs. In addition, Poisson regression model has also been applied to link HTEs and teleconnection patterns. The linkages of HTEs and teleconnection patterns have been identified in both NHPP modeling and Poisson regression. Composite maps of differences of 500-hPa geopotential height and wind fields in the positive and negative phases of teleconnection patterns are constructed to show the impacts of atmospheric circulation patterns on extreme heat events. The spatial pattern of the associated anticyclonic or cyclonic circulations with teleconnection patterns partly explains the spatial variability of the occurrences of summer HTEs over China.
Intravenous Infusion Route in Maternal Resuscitation: A Scoping Review
Authors: Nakamura Eishin , Takahashi Shinji , Matsunaga Shigetaka , Tanaka Hiroaki , Furuta Marie , Sakurai Atsushi 
Published: September 2021

Abstract
Background: The upper extremities can be used as an infusion route during cardiopulmonary resuscitation in pregnant women. This is a reasonable recommendation considering the characteristic circulation of pregnant women, but this method is not based on scientific evidence.Objective of the Review: We conducted a scoping review to determine whether the infusion route should be established above the diaphragm during cardiopulmonary resuscitation in a pregnant woman. Discussion: We included randomized controlled trials (RCTs) and non-RCTs on the infusion of fluids in pregnant women after 20 weeks of gestation requiring establishment of an infusion route due to cardiac arrest, massive bleeding, intra-abdominal bleeding, cesarean section, severe infection, or thrombosis. In total, 3150 articles from electronic database were extracted, respectively. After title and abstract review, 265 articles were extracted, and 116 articles were extracted by full-text screening, which were included in the final analysis. The 116 articles included 78 studies on infusion for pregnant women. The location of the intravenous infusion route could be confirmed in only 17 studies, all of which used the upper extremity to secure the venous route. Conclusion: Pregnant women undergo significant physiological changes that differ from those of normal adults, because of pressure and drainage of the inferior vena cava and pelvic veins by the enlarged uterus. Therefore, despite a lack of evidence, it seems logical to secure the infusion route above the diaphragm when resuscitating a pregnant woman.
The First Conserved Mitochondrial Genome of Polygraphus Poligraphus (Coleoptera: Curculionidae) and Its Phylogenetic Implications
Authors: Song Xianmei , Zhao Yuchen , Zhao Peng , Ma Yinxiang , Bai Ming , Wang Xinpu 
Published: September 2021

Abstract
Background: Polygraphus poligraphus L., the four-eyed spruce bark beetle, belongs to the Curculionidae (Coleoptera), which mainly harms Picea asperata Mast and Pinus armandii Franch tree trunks. So far, there is no mitochondrial genome reported for P. poligraphus.Results: In this study, we sequenced and annotated the nearly complete mitogenome of P. poligraphus for the first time and predicted the secondary structures of its tRNAs. The results showed that the mitogenome of P. poligraphus was 15,302 bp (partial genome) in length with A + T content of 69.65% due to large-scale duplication. The nearly complete mitochondrial genome of P. Poligraphus contained a set of 36 genes typical of the insect mitogenome, including 13 protein-coding genes (PCGs), 2 ribosomal RNA genes (rRNAs), 21 transfer RNA genes (tRNAs) but lacked tRNA-Ile, as for the typical insect mitogenome. The results of nucleotide skew statistics showed that the AT-skews and GC-skew of P. poligraphus were positive and negative, respectively, which were similar to other Scolytinae insects. All PCGs were initiated with the standard start codon ATN. All tRNA genes had the typical cloverleaf structure, except for the trnS1, which lacked a dihydroxyuridine (DHU) arm. Furthermore, we reconstructed phylogenetic trees of P. poligraphus based on the data set of the mitogenome’s protein-coding gene sequences using the Bayesian inference (BI) method. Phylogenetic analysis indicated that the P. poligraphus mitogenome clustered with Gnathotrichus materiarius and Pityophthorus pubescens mitogenomes in a monophyletic manner. The phylogeny of these three genera of Scolytinae is presented as Polygraphus + (Gnathotrichus + Pityophthorus). Conclusions: The results presented herein will provide a reference for further molecular taxonomy, evolution and phylogenetic research of P. poligraphus. However, additional mitogenome samples are still needed to more satisfactorily resolve the phylogeny of the Scolytinae.
GVF27, a human derived peptide with anti-infective properties against biofilm forming members of the Burkholderia cepacia complex
Authors: Bosso Andrea , Gaglione Rosa , Girolamo Rocco Di , Veldhuizen Edwin , García-Vello Pilar , Fusco Salvatore , Cafaro Valeria , Culurciello Rosanna , Notomista Eugenio , Arciello Angela , Pizzo Elio 
Published: September 2021

Abstract
Therapeutic solutions to counter Burkholderia cepacia complex (Bcc) bacteria are challenging due to their intrinsically high level of antibiotic resistance. Bcc organisms display a variety of potential virulence factors, have a distinct lipopolysaccharide naturally implicated in antimicrobial resistance and are able to form biofilms, which may further protect them from both host defence peptides (HDPs) and antibiotics. Here, we report the extremely promising anti-biofilm and immunomodulatory activities of human HDP GVF27 on two of the most clinically relevant Bcc members, as Burkholderia multivorans and Burkholderia cenocepacia. The effects of synthetic and labelled GVF27 were tested on B. cenocepacia and B. multivorans biofilms, at three different stages of formation, by alternative microscopy approaches. Assays on bacterial cultures and on human monocytes challenged with B. cenocepacia LPS, were also performed. GVF27 exerts, at different stages of formation, meaningful anti-biofilm effects towards both Bcc strains, a significant propensity to function in combination with ciprofloxacin, a relevant affinity for LPSs isolated from Burkholderia cenocepacia as well as a good propensity to mitigate the release of pro-inflammatory cytokines in human cells pre-treated with the same endotoxin. Overall, all these findings contribute to the elucidation of the main features that a good therapeutic agent directed against these extremely leathery biofilm-forming bacteria should possess.
Environmental and Economic Benefits of Establishing a Sustainable Transportation System Based on Internet of Things
Authors: Qi Xiaotian 
Published: September 2021

Abstract
The Internet of Things (IoT) is a modern concept which has turned the conventional way of living into a high technology lifestyle. The transformations caused by IoT are the smart city, smart homes, pollution control, energy savings, smart transport and the smart industries. Transportation infrastructure has a huge impact on sustainable development. Sustainable development concerns over environmental quality, social, economic vitality, and climate variation strategic planning due to increasing CO2 have come together to generate an increasing interest in an alternative approach. Sustainable development is very important in any pattern, particularly in the century, and it is therefore very necessary to address sustainable development. In the transport sector, sustainable development can be divided into three main areas: society, economy and environment. Consequently, in this paper, the IoT driven Intelligent Transportation Framework (IoTDITF) has been proposed to establish a sustainable transportation system. Sustainable transport approaches include demand management, price policies, improvement of vehicle technology, clean fuels and integrated land use and transport scheduling. This paper attempts to analyze certain economic problems, such as realistic pricing and the development of an integrated transport network.The findings serve as a guide for policymakers, transport modelers, and planners to adopt indicators on an operating level, thereby simplifying the aggressive task of selecting an indicator.
Security Aspects of Critical Infrastructure Protection in Anthropogenic Disasters: A Case Study of Belgrade
Authors: Cvetković Vladimir M. , Kezunović Andrija 
Published: September 2021

Abstract
Recognized as the basis for maintaining the functionality of the community in disaster conditions, the protection of critical infrastructure is one of the most important measures to improve the resilience of society. Starting from the fact that society can be affected by various natural and anthropogenic disasters, the subject of this chapter refers to a comprehensive analysis of the security aspects of critical infrastructure protection in anthropogenic (man-made) disasters. On the other hand, the social goal of the research is to determine the level of public awareness of the importance of protecting critical infrastructure from these disasters. By applying the quantitative research tradition, quantitative research was realized in the area of ​​the city of Belgrade, in which 200 respondents were interviewed by the method of random sampling. The obtained research results unequivocally indicate that preventive action in this area should be mainly focused on the adoption of strategies based on which plans are made to prevent the occurrence of these disasters, as well as operational procedures for the protection of critical infrastructure.
The influence of direct oral anticoagulants on thrombin generation on Ceveron TGA
Authors: Pfrepper Christian , Behrendt Lisa-Charlott , Bönigk Hagen , Siegemund Thomas , Metze Michael , Franke Dirk , Petros Sirak , Siegemund Annelie 
Published: September 2021

Abstract
Introduction: Monitoring of direct oral anticoagulants (DOACs) with calibrated anti-Xa assay is limited by the high intra- and interindividual variation of the test results. Thrombin generation (TG) is a global hemostatic assay that reflects the patient´s individual coagulation status. The aim of this study was to investigate the influence of DOACs on TG measured with a fully automated assay system. Methods: All consecutive patients under apixaban and rivaroxaban coming to the outpatient coagulation center MVZ Limbach, Magdeburg, Germany between October 2017 and April 2020 were included. DOAC plasma levels were correlated with TG assessed using the fully automated Ceveron TG analyser. Results: A total of 703 rivaroxaban and 252 apixaban containing plasma samples were included. There was a significant correlation between DOAC plasma levels and all TG parameters except for lag time regarding apixaban. Time to peak and peak thrombin followed an exponential regression curve, while this was linear for the endogenous thrombin potential (ETP). Apixaban showed a lower correlation coefficient for all TG parameters compared to rivaroxaban and thrombin generation was less influenced by apixaban than rivaroxaban at plasma levels > 100 ng/mL. The sensitivity and negative predictive value of normal TG parameters for the prediction of DOAC plasma levels < 30 ng/mL was > 85%. Conclusion: The present data show a moderate predominantly non-linear correlation between TG parameters and plasma levels of apixaban and rivaroxaban. Rivaroxaban has a stronger effect on TG than apixaban.
Antipsychotic drugs increase Neuregulin1b1 serum levels in first-episode drug-naïve patients and chronic schizophrenia with suggestions for improving the treatment of psychotic symptoms
Authors: Yang Haidong , Pan Wen , Xiao Wenhuan , Yang Man , Xu Jianchun , Li Jin , Zhang Xiaobin 
Published: September 2021

Abstract
Background: Neuregulin1 (NRG1) plays a role in neuronal migration, regulation of synaptic plasticity, and neural survival, and has been considered to be among the candidate genes for schizophrenia. This study focused on the variations in serum NRG1b1 levels following antipsychotic treatment and the relationship between NRG1b1 level and improvements in psychotic symptoms in first-episode drug-naïve (FEDN) patients and chronic schizophrenia.Methods: A total of 100 patients with schizophrenia were recruited and compared with 79 matched healthy controls. All patients had been drug-naïve for at least four weeks. Serum NRG1b1 levels and positive and negative syndrome scale (PANSS) scores were measured at the baseline and after four weeks. Serum NRG1b1 levels were measured using sandwich enzyme-linked immunosorbent assays (ELISA).Results: Baseline NRG1b1 levels were significantly lower in the patients with schizophrenia compared with the healthy controls. NRG1b1 levels increased significantly following antipsychotic treatment. NRG1b1 levels gradually increased with declining PANSS scores and its three subscales during antipsychotic therapy. The levels of NRG1b1 increased significantly in responders after four weeks of treatment, although non-responders showed no such effect. Correlation analyses showed that the levels of NRG1b1 were negatively correlated with the duration of illness and positively correlated with improvement in symptoms.Conclusion: The levels of serum NRG1b1 and the therapeutic effects gradually increased following treatment, indicating that NRG1b1 may be an indicator of therapy, and that it may also be associated with the pathophysiological mechanism causing schizophrenia, although this possible pathway requires further investigation. Antipsychotic drugs increase Neuregulin1b1 serum levels in first-episode drug-naïve patients and chronic schizophrenia with suggestions for improving the treatment of psychotic symptoms
The Role of Laboratory Parameters in Assessment of Disease Severity and Outcome in COVID-19 patients – A Retrospective Study in a Tertiary Care Centre in Southern India
Authors: B Rajeshwari , Shanmugam Salapathi , Mathan Anila , R Dhananjayan , B Isabella Princess , K Selvan , Ghosh Mitra 
Published: September 2021

Background: Corona Virus Disease 2019 (COVID19) is a global pandemic, the outbreak of which started in China in December 2019. Apart from the clinical symptoms and pulmonary computed tomography (CT) findings, several laboratory biomarkers also play an important role in management of these patients so that immediate attention can be given to those with severe disease and critical illness. In this study we tried to find the association of various laboratory biomarkers in COVID-19 patients, analyzed around the time of admission, with the severity of the disease and outcome.
Methods: In this study 1048 COVID19 positive cases admitted in our hospital during the study period from April 2020 to October 2020 were included. The cases were clinically assessed based on the severity of the disease at the time of presentation and during the course in hospital and categorized into 3 categories as Mild, Moderate and Severe according to our hospital protocol for management of COVID 19 patients. The clinical and laboratory data were retrieved from electronic medical records. The levels of various laboratory parameters at/around the time of admission were compared with clinical categories, severity and outcome of the disease.
Result: We found a statistically significant association of severity and outcome of COVID-19 with various laboratory parameters. There were significantly higher levels of D-dimer, LDH, CK, CRP, Sr Ferritin, cTnI, NT pro BNP, PCT, IL-6 and lower ALC in non survivors compared to survivors and in severe disease compared to mild disease with a p value of <0.05.
Conclusion: In this study we propose that along with the initial clinical assessment, age and concurrent co-morbidities of COVID-19 patients which determine the need for their admission to ICUs, the initial assessment of several laboratory parameters is helpful in triaging the patients who need intensive care so that proper allocation of resources can be done.