bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of thermostable phytase supplemented in diets on growth performance and nutrient utilization of broilers
Authors: Song Tingting , Yu Caiyun , Zhao Xu , Chen Fengliang , Liu Yanjie , Yang Chongwu , Yang Zaibin 
Published: February 2021

AbstractPhytase is an enzyme that has the ability to release phosphorous (P) from phytate by hydrolyzing inositol‐phosphate linkages. Recently, thermostable phytases have gained great consideration because the reduction in phytase activity was found when exposed to heat during feed pelleting. In this study, the effects of the granular thermostable phytase (Aspergillus niger) on growth performance and nutrient utilization of broilers were investigated. A total of 96 21‐day‐old Arbor Acres broilers were randomly distributed into six treatments including basal diet (control) and basal diet supplemented with 500, 1,000, 2,000, 4,000, 8,000 U of phytase/kg. In general, the metabolizable energy (ME) and the apparent and true availability of dry matter (DM), organic matter (OM), ether extract (EE), crude protein (CP), and amino acids (AA) showed both linearly (p < .01) and quadratically (p < .01) increase with increasing levels of phytase in the diet. Additionally, diet supplementation with phytase could improve (p < .05) body weight (BW), average daily gain (ADG), and feed/gain (F/G) on day 42 compared with the control. The results suggested that diet supplementation of the granular thermostable phytase in the crumbled pellets could improve chicken growth performance and nutrient utilization.
A digital self‐report survey of mood for bipolar disorder
Authors: Sagorac Gruichich Tijana , David Gomez Juan Camilo , Zayas‐Cabán Gabriel , McInnis Melvin G. , Cochran Amy L. 
Published: February 2021

AbstractObjectivesBipolar disorder (BP) is commonly researched in digital settings. As a result, standardized digital tools are needed to measure mood. We sought to validate a new survey that is brief, validated in digital form, and able to separately measure manic and depressive severity.MethodsWe introduce a 6‐item digital survey, called digiBP, for measuring mood in BP. It has three depressive items (depressed mood, fidgeting, fatigue), two manic items (increased energy, rapid speech), and one mixed item (irritability); and recovers two scores (m and d) to measure manic and depressive severity. In a secondary analysis of individuals with BP who monitored their symptoms over 6 weeks (n = 43), we perform a series of analyses to validate the digiBP survey internally, externally, and as a longitudinal measure.ResultsWe first verify a conceptual model for the survey in which items load onto two factors (“manic” and “depressive”). We then show weekly averages of m and d scores from digiBP can explain significant variation in weekly scores from the Young Mania Rating Scale (R2 = 0.47) and SIGH‐D (R2 = 0.58). Lastly, we examine the utility of the survey as a longitudinal measure by predicting an individual’s future m and d scores from their past m and d scores.ConclusionsWhile further validation is warranted in larger, diverse populations, these validation analyses should encourage researchers to consider digiBP for their next digital study of BP.
Mixed axial and transverse deep‐water systems: The Cretaceous post‐rift Lysing Formation, offshore Norway
Authors: Hansen L. A. S. , Hodgson D. M. , Pontén A. , Thrana C. , Obradors Latre A. 
Published: February 2021

AbstractDeep‐water stratigraphic successions from syn‐ to post‐rift stages are an archive of evolving physiographic configurations, and can record axial and transverse sedimentary sources. The healing of topography decreases the influence of syn‐rift structures on sedimentation patterns and transport processes over time, which leads to a long‐term transition from dominantly axial to transverse dispersal patterns. The Halten and Dønna terraces, offshore mid‐Norway, comprise a series of rift‐related sub‐basins established during the Jurassic, which were infilled with sediments during the Cretaceous. The Cretaceous Lysing Formation developed as slope‐ and basin‐floor fans within a series of weakly confined post‐rift sub‐basins with some shallow marine deposits interpreted on the basin margins. A deep‐water setting is supported by seismic interpretation, and bed type and architectural element analysis in all cored and uncored wells in the area. We document that an axial submarine fan system was active throughout the post‐rift stage due to subtle inherited topography from syn‐rift structures, which interacted with locally sourced transverse sediment sources. This led to a complicated stratigraphic architecture, with lobe fringe deposits of the axial fan system juxtaposed with channel‐fills and channel‐lobe transition zone deposits of transverse systems. The refined palaeogeographic reconstruction of the Lysing Formation illustrates how subtle topography can impact sediment routing patterns many millions of years after the end of rifting and can be used for palaeoenvironmental interpretations in other post‐rift settings.
Thrust duplexing and transpression in the Yanshan Mountains: Implications for early Mesozoic orogenesis and decratonization of the North China Craton
Authors: Liu Shaofeng , Zhang Andong , Lin Chengfa , Zhang Bo , Yuan Haotian , Huang Diying , Steel Ronald J. , Horton Brian K. 
Published: February 2021

AbstractThe configuration and kinematics of fold‐thrust belts are essential for clarifying the plate boundary conditions through which ancient orogenic belts evolved. Temporal and spatial variations in extension versus contraction within convergent plate margins are related to changes in plate kinematics and subduction geometry. The Yanshan Mountains, located along the northeastern margin of the North China Craton and bounded by the Central Asian Orogenic Belt to the north and the Pacific subduction zone to the east, underwent multiple phases of intra‐continental deformation during the Mesozoic. The issue of whether early Mesozoic deformation was extensional or contractional has remained controversial. New regional structural mapping and detailed sedimentological investigations, coupled with age constraints provided by zircon U‐Pb geochronology, provide sufficient temporal and spatial resolution to show that shortening and thrust‐top basin systems dominated during the early Mesozoic. Our results show that the Dengzhangzi Basin within the Lingyuan fold‐thrust belt developed during the construction of a major Late Triassic Chapeng antiformal‐stack duplex system, with episodic, east‐vergent forward‐breaking thrusts and subsequent ‘beheading’ by out‐of‐sequence, top‐to‐east thrusting in the latest Triassic or earliest Jurassic. The neighbouring Guojiadian Basin in the east was generated during top‐to‐SSE sinistral transpression along the Niuyingzi thrust system in the Middle to earliest Late Jurassic. These results support a new model of early craton decratonization involving (a) thrusting along the northern margin of the North China Craton and (b) transpressional deformation in the east driven by the Central Asian Ocean collision and flat‐slab subduction of the Palaeo‐Pacific Plate beneath the East Asian continental margin. Our findings suggest that large‐scale shortening and crustal/lithospheric thickening, triggered by flat‐slab subduction in the North China Craton, were fundamental components of craton decratonization. Subsequent slab roll‐back during the Cretaceous led to lithospheric thinning and crustal extension in the North China Craton.
Vascular reconstitution in the tumor for more effective tumor immunotherapy
Authors: Takakura Nobuyuki 
Published: February 2021

AbstractIt has been widely accepted that the regulation of the tumor microenvironment is an important strategy in cancer treatment. Particularly, control of the tumor vasculature has been suggested to be critical for antitumor immunotherapy. Effectiveness of cancer immunotherapy depends on the quality and quantity of immune cells infiltrating into tumor tissues, which may be affected by the status of the tumor vasculature. Under physiological conditions, immune cells migrate from the intravascular lumen into the parenchyma especially by passing through the vascular wall of venulae. Extravasation of immune cells is induced from venulae where endothelial cells (ECs) are fully covered with pericytes from the basal side. Interaction of pericytes with ECs contributes to immune cell extravasation by several steps, ie, adhesion of immune cells to intraluminal ECs, transmigration, and chemotaxis of immune cells. Blood vessels are structurally immature and non‐functional in tumors, and therefore, induction of maturation in the tumor vasculature is a promising strategy for effective cancer therapies and is relevant not only for immune cell migration but also drug delivery.
Immune deficiency, autoimmune disease and intellectual disability: A pleiotropic disorder caused by biallelic variants in the TPP2 gene
Authors: Atallah Isis , Quinodoz Mathieu , Campos‐Xavier Belinda , Peter Virginie G. , Fouriki Athina , Bonvin Christophe , Bottani Armand , Kumps Camille , Angelini Federica , Bellutti Enders Felicitas , Christen‐Zaech Stéphanie , Rizzi Mattia , Renella Raffaele , Beck‐Popovic Maja , Poloni Claudia , Frossard Valérie , Blouin Jean‐Louis , Rivolta Carlo , Riccio Orbicia , Candotti Fabio , Hofer Michael , Unger Sheila , Superti‐Furga Andrea 
Published: February 2021

AbstractFour individuals from two families presented with a multisystemic condition of suspected genetic origin that was diagnosed only after genome analysis. The main phenotypic features were immune system dysregulation (severe immunodeficiency with autoimmunity) and intellectual disability. The four individuals were found to be homozygous for a 4.4 Kb deletion removing exons 20–23 (NM_003291.4) of the TPP2 gene, predicting a frameshift with premature termination of the protein. The deletion was located on a shared chromosome 13 haplotype indicating a Swiss founder mutation. Tripeptidyl peptidase 2 (TPP2) is a protease involved in HLA/antigen complex processing and amino acid homeostasis. Biallelic variants in TPP2 have been described in 10 individuals with variable features including immune deficiency, autoimmune cytopenias, and intellectual disability or chronic sterile brain inflammation mimicking multiple sclerosis. Our observations further delineate this severe condition not yet included in the OMIM catalog. Timely recognition of TPP2 deficiency is crucial since (1) immune surveillance is needed and hematopoietic stem cell transplantation may be necessary, and (2) for provision of genetic counselling. Additionally, enzyme replacement therapy, as already established for TPP1 deficiency, might be an option in the future.
Parasites as conservation tools
Authors: Gagne Roderick B. , Crooks Kevin R. , Craft Meggan E. , Chiu Elliott S. , Fountain‐Jones Nicholas M. , Malmberg Jennifer L. , Carver Scott , Funk W. Chris , VandeWoude Sue 
Published: February 2021

AbstractParasite success typically depends on a close relationship with one or more hosts; therefore, attributes of parasitic infection have the potential to provide indirect details of host natural history and are biologically relevant to animal conservation. Characterization of parasite infections has been useful in delineating host populations and has served as a proxy for assessment of environmental quality. In other cases, the utility of parasites is just being explored, for example, as indicators of host connectivity. Innovative studies of parasite biology can provide information to manage major conservation threats by using parasite assemblage, prevalence, or genetic data to provide insights into the host. Overexploitation, habitat loss and fragmentation, invasive species, and climate change are major threats to animal conservation, and all of these can be informed by parasites.
An experimental study on dyeing of needle‐punched polyethylene‐terephthalate non‐wovens
Authors: Khawar Muhammad Tauseef , Tausif Muhammad , Ashraf Munir , Ahmad Faheem , Ahmad Sheraz , Azam Farooq , Khattak Mehran 
Published: February 2021

AbstractThe dyeing of non‐wovens in fabric form is of interest for a range of applications especially aesthetics. In this work, needle‐punched non‐woven fabrics were prepared by employing polyethylene‐terephthalate (PET) fibres of two different linear density and same mean fibre length in four different fibre linear density ratios and three different fabric mass areal densities, while keeping all other process and material variables constant. The objectives of the study were to find out the saturation point in the dyeing profile of needle‐punched non‐wovens by varying aforementioned process variables and, for the first time, compare different industrially relevant conventional fabric dyeing methods (Jet, Package and Jigger dyeing) in terms of physical, mechanical and colour fastness properties. In case of Jet and Package dyeing, non‐woven fabric was successfully dyed without any structural reorientation while fabric sample deformation is reported in Jigger dyeing process. Furthermore, tensile strength (in newtons) of samples was increased, while air permeability (in mm/s) was decreased due to the slight compactness of structure after the dyeing process.
Dermal melanocytic tumor with CRTC1‐TRIM11 fusion: Report of two additional cases with review of the literature of an emerging entity
Authors: Parra Ourania , Bridge Julia A. , Busam Klaus J. , Shalin Sara C. , Linos Konstantinos 
Published: February 2021

Abstract“Cutaneous melanocytic tumor with CRTC1‐TRIM11 fusion” (CMTCT) is a newly described, potentially novel entity that typically presents as a dermal nodule on the head and neck, extremities, and trunk of adults. Histopathologically, it is reported as a nodular or multinodular tumor composed of epithelioid and spindle cells that are variably immunoreactive for S100‐protein, SOX10, and MITF along with more specific melanocytic markers such as MelanA and HMB45. With only 11 cases reported in the English literature so far, the neoplasm appears to behave in a relatively indolent fashion. Nevertheless, in one case, local recurrence and synchronous distant metastasis were evident after 13 years. Additional cases with longer follow‐up are essential to determine the neoplasm's biologic behavior with more accuracy. Herein, two cases of CMTCT, one arising on the lower back of a 65‐year‐old female and the other on the arm of a 33‐year‐old female in addition to a comprehensive literature review are reported.
Fine‐scale chemostratigraphy of cross‐sectioned hydrogenous ferromanganese nodules from the western North Pacific
Authors: Machida Shiki , Nakamura Kentaro , Kogiso Tetsu , Shimomura Ryo , Horinouchi Koichi , Okino Kyoko , Kato Yasuhiro 
Published: February 2021

AbstractA broad area densely covered by ferromanganese nodules was recently discovered around Minamitorishima (Marcus) Island, representing a high‐potential metal resource, particularly for Co, Ni, Mo, and W. We studied 16 nodule samples from nodule fields around Minamitorishima Island. To define the fine‐scale chemostratigraphy of the nodules, polished cross‐sections of the samples were analyzed by microfocus X‐ray fluorescence. Our results show that a general pattern of compositional variation was common throughout the growth history of the nodules in all the regions we studied. Chemical mapping clarified changes in the chemical signature and proportion of five lithological components throughout the growth history: Mn represented columnar δ‐MnO2; Fe represented layered amorphous FeOOH*xH2O; Ti represented TiO2*2H2O intergrown with an amorphous FeOOH phase; P, Ca and Y represented particles of biogenic calcium phosphate; and Si, Al, K, Cu, and Ni represented pelagic sediment infills. We proposed a method for a creating a multi‐dimensional compositional map of the fine‐scale chemostratigraphy observed in the ferromanganese oxide layers on the basis of merging the mapped Mn, Fe, Ti, P, Si and Cu intensities. Multi‐dimensional compositional mapping of the sampled nodules from the western North Pacific revealed two fundamental findings: (1) previously recognized first‐order Fe–Mn layers, L0, L1, and L2, were further divided into two, three, and four sublayers, respectively, and (2) a delayed supply of material to be nuclei of nodule or a growth hiatus of Fe–Mn layer(s), leading to missing sublayers in the layers L0 and L2, regulated the nodule size. In contrast, layer L1, which does not have any missing sublayers, was commonly observed in the samples for this study and has been reported in studies of other regions in the western Pacific. We propose, therefore, that the layer L1 is a key facies for examining chemostratigraphic correlations with other areas of seafloor.
Profiles of volatile compounds and sensory characteristics of Robusta coffee beans roasted by hot air and superheated steam
Authors: Chindapan Nathamol , Puangngoen Chanakan , Devahastin Sakamon 
Published: February 2021

SummaryAlthough superheated steam (SHS) roasting has proved to be capable of improving selected quality of roasted Robusta coffee beans, impact of SHS roasting on aroma characteristics of the beans is not well understood. This study therefore aimed to investigate the effect of SHS roasting on aroma profiles and sensory characteristics of Robusta beans undergone SHS roasting at 190–250 °C; results were compared with those of beans roasted by hot air (HA). Sensory characteristics of selected samples were also compared with HA‐roasted Arabica beans. Forty five aroma compounds were identified; most were fully developed in beans roasted at 230 °C and tended to degrade in beans roasted at 250 °C. SHS roasting led to more extensive formation of aroma compounds contributing to caramel note, while helped reduce formation of major contributors to spicy, roasty and burnt notes. SHS‐roasted Robusta beans exhibited more resemblance to Arabica beans than their HA‐roasted counterpart.
Fortification using grape extract polyphenols – a review on functional food regulations
Authors: Sridhar Kandi , Charles Albert Linton 
Published: February 2021

SummaryGrapes are rich sources of polyphenols and widely used in food fortification due to their health‐promoting properties. Previous studies have provided systematic strategies on foods fortified with grape polyphenols; however, until now, very little is known about grape polyphenol market, fortification and their health food regulations. It is, therefore, necessary to make a comprehensive overview of grape extract polyphenols and their fortification in functional foods. Hence, we reviewed the grape polyphenol market, fortification, health food market scenario and functional food regulations. The global grape polyphenol market is expected to rise 946.90 million USD by 2023 with its own trademark as polyphenol‐fortified functional foods. This is ultimately due to acceptability, extensive use, marketing of polyphenol‐fortified functional foods and their favourable food regulations. The future perspective on grape polyphenols research should be focused on extraction of polyphenols from grape waste and their fortification in functional foods.
Quality attributes and rheological properties of novel high milk protein‐based extrudates made by supercritical fluid extrusion
Authors: Zhou Ran , Mitra Pranabendu , Melnychenko Andrew , Rizvi Syed S.H. 
Published: February 2021

SummarySupercritical fluid extrusion (SCFX) process has opened up a new way of extruding heat‐sensitive materials such as milk protein concentrate (MPC) into novel nutritional porous extrudates. Three formulations (30%:66.5%, 60%:36.5% and 90%:6.5% of MPC: rice flour, w/w) with 1% Dimodan, 1% lecithin and 1.5% salt were extruded by using SCFX. The physical, rheological and thermal properties of the extrudates were evaluated. The results showed that the increased MPC contents decreased gelatinisation enthalpy and increased the viscosity of the extrudates, which contributed to develop stable porous extrudates; and the increased MPC contents also helped to form a stronger gel network existed in dispersion of the extrudate samples, which resulted in a higher stress to break the gel and flow. The radial and overall expansions, crispness, porosity, rehydration ratio, moisture content and water activity increased while the axial expansion, hardness, piece density, apparent density, bulk density, decreased with higher amounts of MPC contents in extrudates. The overall results indicated that 90% MPC‐containing extrudate was very suitable for developing highly nutritional and healthy cereals/snacks.
Comparison between discrete and continuous analysis of facial expressions, elicited by bitter‐tasting beverages in overweight and healthy‐weight individuals
Authors: Rocha‐Parra Diego , León Bianchi Luciana , Gentico Fernando , Garcia‐Burgos David , Zamora María C. 
Published: February 2021

SummaryThe aim of the present study was to compare the information provided by a discrete and continuous data analysis of two emotions (disgust and joy), elicited by bitter‐tasting beverages (coffee, yerba mate infusion and grapefruit juice) in two groups with different body mass index (BMI): overweight group (25 < BMI < 30), and healthy‐weight control group (18.5 < BMI ≤ 25). Participants (n = 66; 34 females, 32 males) evaluated a total of three consecutive sips of the same beverage (taking one sip every 20 s and registering a continuous video for 60 s). The Wilcoxon test (continuous analysis) showed some changes generated as the drinks were being consumed. The biggest difference was the expression of disgust for coffee in the high BMI group, at the first sip (0–10 s). It represented 27% compared to 2% in normal BMI. The continuous analysis allowed to observe the periods where the differences were greater (0–10 and 40–50 s).
Evolutionary insights into the genomic organization of major ribosomal DNA in ant chromosomes
Authors: Teixeira G. A. , de Aguiar H. J. A. C. , Petitclerc F. , Orivel J. , Lopes D. M. , Barros L. A. C. 
Published: February 2021

AbstractThe major rDNA genes are composed of tandem repeats and are part of the nucleolus organizing regions (NORs). They are highly conserved and therefore useful in understanding the evolutionary patterns of chromosomal locations. The evolutionary dynamics of the karyotype may affect the organization of rDNA genes within chromosomes. In this study, we physically mapped 18S rDNA genes in 13 Neotropical ant species from four subfamilies using fluorescence in situ hybridization. Furthermore, a survey of published rDNA cytogenetic data for 50 additional species was performed, which allowed us to detect the evolutionary patterns of these genes in ant chromosomes. Species from the Neotropical, Palearctic, and Australian regions, comprising a total of 63 species from 19 genera within six subfamilies, were analysed. Most of the species (48 out of 63) had rDNA genes restricted to a single chromosome pair in their intrachromosomal regions. The position of rDNA genes within the chromosomes appears to hinder their dispersal throughout the genome, as translocations and ectopic recombination are uncommon in intrachromosomal regions because they can generate meiotic abnormalities. Therefore, rDNA genes restricted to a single chromosome pair seem to be a plesiomorphic feature in ants, while multiple rDNA sites, observed in distinct subfamilies, may have independent origins in different genera.