bluuebunny/crossref_metadata_2025_split huggingface dataset:
EMT-independent detection of circulating tumor cells in human blood samples and pre-clinical mouse models of metastasis
Authors: Kitz Jenna , Goodale David , Postenka Carl , Lowes Lori E. , Allan Alison L. 
Published: January 2021

AbstractCirculating tumor cells (CTCs) present an opportunity to detect/monitor metastasis throughout disease progression. The CellSearch® is currently the only FDA-approved technology for CTC detection in patients. The main limitation of this system is its reliance on epithelial markers for CTC isolation/enumeration, which reduces its ability to detect more aggressive mesenchymal CTCs that are generated during metastasis via epithelial-to-mesenchymal transition (EMT). This Technical Note describes and validates two EMT-independent CTC analysis protocols; one for human samples using Parsortix® and one for mouse samples using VyCap. Parsortix® identifies significantly more mesenchymal human CTCs compared to the clinical CellSearch® test, and VyCap identifies significantly more CTCs compared to our mouse CellSearch® protocol regardless of EMT status. Recovery and downstream molecular characterization of CTCs is highly feasible using both Parsortix® and VyCap. The described CTC protocols can be used by investigators to study CTC generation, EMT and metastasis in both pre-clinical models and clinical samples.
Prehistoric Mongolian Archaeology in the Early 21st Century: Developments in the Steppe and Beyond
Authors: Wright Joshua 
Published: January 2021

AbstractThere has been a great increase in archaeological research in Mongolia since 2000. Increasingly precise chronologies, regional studies, and the growth of development-driven archaeology are transforming our knowledge of this key region of northeastern Asia. This review summarizes recent work and provides a narrative of the prehistoric and medieval cultural sequences as presently understood. I focus on long-standing key topics: early human habitation, the adoption of food-producing economies, Bronze Age social transformations, and the emergence of central places and large polities. I argue that, on the one hand, Mongolia has unique data and new examples to offer the archaeological community and, on the other, that the prehistory of Mongolia and the steppe are not so different from the rest of the world in its history of research and key questions. This review provides general overviews covering the Upper Paleolithic, Epipaleolithic or Neolithic, and Bronze Age to the Xiongnu period; specific data related to each period provide jumping-off points for comparative analysis and further examination.
Ocean state estimations for synthesis of ocean-mixing observations
Authors: Masuda Shuhei , Osafune Satoshi 
Published: January 2021

AbstractVertical mixing in oceans is an essential component of the dynamics of ocean circulation, including meridional circulation. Nevertheless, various aspects of mixing, particularly in conjunction with global ocean energetics, remain debatable. One of the biggest reasons is the lack of observational facts. With the recent expansion of global vertical-mixing observations, attempts have been made to estimate the ocean state using vertical-mixing observation data to better understand the role of mixing in oceanography. In this review, we discuss the current status of the ocean state estimation and future synthesis of vertically mixing observation data into the oceanic basin-scale state estimation, including progress of data assimilation studies using numerical models. These will contribute to the construction of the future line of observation, model, and data synthesis studies along which the issues on ocean mixing can be consistently resolved.
The retrospective study of perioperative application of dexamethasone and furosemide for postoperative anti-inflammation in patients undergoing percutaneous nephrolithotomy
Authors: Qi Taiguo , Qi Xia , Chen Xiude , Jin Xunbo 
Published: January 2021

Abstract
Objectives
To investigate whether the perioperatively combined application of dexamethasone and furosemide could alleviate the inflammation in patients undergoing percutaneous nephrolithotomy (PCNL).

Patients and methods
147 patients undergoing PCNL between November 2018 and October 2019 were enrolled in the study. 77 patients accepted a single dose of dexamethasone and furosemide administration (EXP group, n = 77), and 70 patients did not (CON group, n = 70). Demographic and perioperative data, inflammatory markers including interleukin-6 (IL-6) and procalcitonin (PCT), and clinical outcomes were compared between the two groups.

Results
Compared with the CON group, the incidence rate of urosepsis of the EXP group were significantly lower (11.69% vs. 24.29%, p = 0.046). 3 patients developed severe urosepsis in the EXP group, while 5 patients developed severe urosepsis in the CON group. Compared with those in the CON group, the patients with postoperative urosepsis in the EXP group showed lower serum levels of IL-6 at postoperative hour two (p = 0.045) and at postoperative day one (p = 0.031) and lower serum levels of PCT at postoperative day one (p = 0.015). There was a better clinical outcome of a shorter postoperative hospital stay (p = 0.015) in patients with postoperative urosepsis in the EXP group than in those in the CON group.

Conclusion
The perioperatively combined application of dexamethasone and furosemide was beneficial for alleviating postoperative inflammatory reaction and caused a better clinical outcome of a shorter postoperative hospital stay.
MIPLIB 2017: data-driven compilation of the 6th mixed-integer programming library
Authors: Gleixner Ambros , Hendel Gregor , Gamrath Gerald , Achterberg Tobias , Bastubbe Michael , Berthold Timo , Christophel Philipp , Jarck Kati , Koch Thorsten , Linderoth Jeff , Lübbecke Marco , Mittelmann Hans D. , Ozyurt Derya , Ralphs Ted K. , Salvagnin Domenico , Shinano Yuji 
Published: January 2021

AbstractWe report on the selection process leading to the sixth version of the Mixed Integer Programming Library, MIPLIB 2017. Selected from an initial pool of 5721 instances, the new MIPLIB 2017 collection consists of 1065 instances. A subset of 240 instances was specially selected for benchmarking solver performance. For the first time, these sets were compiled using a data-driven selection process supported by the solution of a sequence of mixed integer optimization problems, which encode requirements on diversity and balancedness with respect to instance features and performance data.
The PANDA Framework for Hierarchical Planning
Authors: Höller Daniel , Behnke Gregor , Bercher Pascal , Biundo Susanne 
Published: January 2021

AbstractDuring the last years, much progress has been made in hierarchical planning towards domain-independent systems that come with sophisticated techniques to solve planning problems instead of relying on advice in the input model. Several of these novel methods have been integrated into thePANDA framework, which is a software system to reason about hierarchical planning tasks. Besides solvers for planning problems based on plan space search, progression search, and translation to propositional logic, it also includes techniques for related problems like plan repair, plan and goal recognition, or plan verification. These various techniques share a common infrastructure, like e.g. a standard input language or components for grounding and reachability analysis. This article gives an overview over the PANDA framework, introduces the basic techniques from a high level perspective, and surveys the literature describing the diverse components in detail.
Nutritional Deficiencies and Maternal Depression: Associations and Interventions in Lower and Middle-Income Countries: a Systematic Review of Literature
Authors: Madeghe Beatrice A. , Kogi-Makau Wambui , Ngala Sophia , Kumar Manasi 
Published: January 2021

Abstract
Background
Nutrition deficiencies are common among pregnant and lactating women in middle- and low-income countries. At the same time, maternal mental disorders, mainly depression is highly prevalent during this period suggesting some connection between the two. The objective of this review is to determine the associations between nutritional deficiencies and maternal depression and identify the role of diet in depression to facilitate further research.

Methods
A literature search included PubMed databases and Google Scholar search engine published from June 2008 to June 2019 and published in English. Medical subject heading terms was used to identify all relevant studies. All titles and abstracts identified by the search were screened then reviewed the full-text articles which were potentially eligible for inclusion.

Results
The original search identified 1250 articles but with cascaded elimination, based on quality. Twenty five met the inclusion criteria, of which 13 were cross-sectional, eight were prospective cohort study, and four were intervention studies. Most (95%) of these studies reported positive associations between nutrition deficiencies, poor diet, and maternal depression; thus, only 5% did not show associations between nutrition and depression.

Conclusion
Our review findings suggest that nutritional interventions are some of the most promising intercessions for mental health illnesses. Not all studies consistently associate poor diet quality with poor maternal and offspring mental health outcomes, and the majority of those that show are cross-sectional. Considering that most of these associations are cross-sectional, studies devoid of exposing causal relationship; thus, longitudinal studies are needed to confirm the associations towards sufficing as a window of opportunity for reducing the risk of mental disorders in mothers and offspring alike.
Iranian kinect face database (IKFDB): a color-depth based face database collected by kinect v.2 sensor
Authors: Mousavi Seyed Muhammad Hossein , Mirinezhad S. Younes 
Published: January 2021

AbstractThis study presents a new color-depth based face database gathered from different genders and age ranges from Iranian subjects. Using suitable databases, it is possible to validate and assess available methods in different research fields. This database has application in different fields such as face recognition, age estimation and Facial Expression Recognition and Facial Micro Expressions Recognition. Image databases based on their size and resolution are mostly large. Color images usually consist of three channels namely Red, Green and Blue. But in the last decade, another aspect of image type has emerged, named “depth image”. Depth images are used in calculating range and distance between objects and the sensor. Depending on the depth sensor technology, it is possible to acquire range data differently. Kinect sensor version 2 is capable of acquiring color and depth data simultaneously. Facial expression recognition is an important field in image processing, which has multiple uses from animation to psychology. Currently, there is a few numbers of color-depth (RGB-D) facial micro expressions recognition databases existing. With adding depth data to color data, the accuracy of final recognition will be increased. Due to the shortage of color-depth based facial expression databases and some weakness in available ones, a new and almost perfect RGB-D face database is presented in this paper, covering Middle-Eastern face type. In the validation section, the database will be compared with some famous benchmark face databases. For evaluation, Histogram Oriented Gradients features are extracted, and classification algorithms such as Support Vector Machine, Multi-Layer Neural Network and a deep learning method, called Convolutional Neural Network or are employed. The results are so promising.
Nutrient retention behind a tropical mega-dam: a case study of the Sardar Sarovar Dam, India
Authors: Gupta Harish , Reddy S. Kiran Kumar , Chiluka Mounika , Gandla Vamshikrishna 
Published: January 2021

AbstractIn this study, we demonstrate the impact of the construction of a mega-dam on the nutrient export regime of a large tropical river into the Arabian Sea. Long-term (11 years) fortnight nutrient parameters, upstream and downstream to Sardar Sarovar (SS) Dam, were examined to determine the periodical change in nutrient fluxes from the Narmada River, India. During this 11-year period, the average discharge of the Narmada River upstream toRajghat(35.3 km3 year−1) was higher than that of downstream atGarudeshwar(33.9 km3 year−1). However, during the same period, the suspended sediment load was reduced by 21 million tons (MT) from 37.9 MT atRajghatto 16.7 MT atGarudeshwar. Similarly, mean concentrations of dissolved silica (DSi) reduced from 470 (upstream) to 214 µM (downstream), dissolved inorganic phosphate (DIP) from 0.84 to 0.38 µM, and dissolved inorganic nitrogen (DIN) from 43 to 1.5 µM. It means that about 54%, 55%, and 96% flux of DSi, DIP, and DIN retained behind the dam, respectively. The estimated denitrification rate (80,000 kg N km−2 year−1) for the reservoir is significantly higher than N removal by lentic systems, globally. We hypothesize that processes such as biological uptake and denitrification under anoxic conditions could be a key reason for the significant loss of nutrients, particularly of DIN. Finally, we anticipated that a decline in DIN fluxes (by 1.13 × 109 mol year−1) from the Narmada River to the Arabian Sea might reduce the atmospheric CO2fixation by 7.46 × 109 mol year−1.
Gender und der überfrachtete kolumbianische Frieden
Authors: Oettler Anika 
Published: January 2021

ZusammenfassungDas 2016 unterzeichnete Friedensabkommen zwischen der kolumbianischen Regierung und der FARC-EP hat sowohl in prozeduraler als auch in substantieller Hinsicht neue Maßstäbe für inklusive Friedensprozesse gesetzt. Der Beitrag konzentriert sich auf die kontroverse Einbeziehung einer Vielfalt von genderbezogenen Maßnahmen in den Vertragstext, die das Ergebnis von transnationalen Normentwicklungen und lokalen Kämpfen ist. Im Mittelpunkt des Beitrages steht der Vertragstext selbst. Es wird zunächst aufgezeigt, wie sich die Debatte um eine angeblich vorhandene Gender-Ideologie nach dem Scheitern der Volksabstimmung auf die revidierte Fassung des Abkommens ausgewirkt hat: der Begriff wurde vermieden und ein traditionelles Geschlechterverständnis gestärkt, ohne dabei jedoch die Vielzahl von Einzelmaßnahmen zu reduzieren. Die hier vorgeschlagene qualitative Systematik der genderbezogenen Einzelmaßnahmen zeigt auf, dass es sich überwiegend um Maßnahmen zur Bearbeitung von Konfliktursachen mit einem geringen Konkretisierungsgrad handelt. Dies geht mit einer bisher geringen Implementierung in diesen Feldern einher. Der Beitrag zeigt, wie mit einer prioritätslosen Fülle von genderbezogenen Einzelmaßnahmen leicht ein Umschlagpunkt erreicht wird, an dem sich das eigentliche Anliegen feministischer Bewegungen – die strukturellen Konfliktursachen anzugehen – verliert.
Linking crop yields in Tuscany, Italy, to large-scale atmospheric variability, circulation regimes and weather types
Authors: Salinger M. James , Dalla Marta Anna , Dalu Giovannagelo , Messeri Alessandro , Baldi Marina , Messeri Gianni , Vallorani Roberto , Morabito Marco , Orlandini Simone , Altobelli Filiberto , Verdi Leonardo 
Published: January 2021

AbstractThe paper presents results from a study examining the relationship between large-scale modes of climate variability with the fluctuations in the yield of barley, durum wheat, olives and sunflower crops in Tuscany, Italy. In particular, the blocking circulation over the growing season, with associated hot and dry conditions, decreased yield for olive crops, barley and durum wheat. The teleconnections analysed in this study are the winter North Atlantic Oscillation (NAO) and the Summer North Atlantic Oscillation (SNAO); the West African Monsoon (WAM) and the Intertropical Front (ITF); and although NAO, SNAO, ITF and WAM are not strictly related to each other, the values of these indices are strongly related to the atmospheric circulation regimes and related weather types. Thus, they have an impact on precipitation and temperature patterns in Italy and on yields of important crops in Tuscany. Results show that the large-scale temperate and tropical variability directly influences the crop yield through three main circulation regimes. These patterns illustrate the importance of the large-scale modes, which, together with the associated weather types, have an impact directly on Tuscan crop yields; both barley and olive yields decline significantly when the ITF is further north with warmer and drier conditions in Italy.
Scanning electron microscopy observations of pollen morphology in common vetch (Vicia sativa) subspecies
Authors: Dong Rui , Lu Zhongjie , Yang Zhengyu , Wang Yanrong , Chen Chao 
Published: January 2021

AbstractCommon vetch (Vicia sativa) is an important forage and green manure crop that is widely cultivated around the world. However, the large number of subspecies and accessions of common vetch has made taxonomic research on this species difficult. Pollen morphology data can provide important evidence in the study of plant phylogeny. Therefore, in this research, light microscopy and scanning electron microscopy were used to observe seven morphological traits of pollens from 22 common vetch accessions, and residual maximum likelihood and pattern analysis was conducted. The results showed that the pollen grains of the 22 accessions were all monad pollen and the polar view revealed three-lobed circular and triangular shapes, while the equatorial view mainly revealed an oblate shape; only one accession showed an oblate spherical shape. All accessions were 3-zonocolporate and the colpus length extended close to the poles. The polar axis length was (19.39 ± 0.97)–(42.12 ± 0.76) μm and the equatorial axis length was (35.97 ± 1.27)–(45.25 ± 0.81) μm. We found that qualitative traits of pollen shape, aperture polar view and ornamentation were highly stable. Among them, polar axis length, equatorial axis length and colpus length and width had significant differences among the accessions. The ratios of the equatorial and polar axes had significant differences among the subspecies. This trait information could be used for the classification and identification of common vetch accessions and subspecies.
THE EARLY MODERN ORIGINS OF BEHAVIORAL ECONOMICS
Authors: Boyd Richard 
Published: January 2021

AbstractFor all the recent discoveries of behavioral psychology and experimental economics, the spirit of homo economicus still dominates the contemporary disciplines of economics, political science, and sociology. Turning back to the earliest chapters of political economy, however, reveals that pioneering figures such as Francis Bacon, Thomas Hobbes, and Adam Smith were hardly apostles of economic rationality as they are often portrayed in influential narratives of the development of the social sciences. As we will see, while all three of these thinkers can plausibly be read as endorsing “rationality,” they were also well aware of the systematic irrationality of human conduct, including a remarkable number of the cognitive biases later “discovered” by contemporary behavioral economists. Building on these insights I offer modest suggestions for how these thinkers, properly understood, might carry the behavioral revolution in different directions than those heretofore suggested.
Comprehensive or Political Liberalism? The Impartial Spectator and the Justification of Political Principles
Authors: Ben-Moshe Nir 
Published: January 2021

AbstractJohn Rawls raises three challenges – to which one can add a fourth challenge – to an impartial spectator account: (a) the impartial spectator is a utility-maximizing device that does not take seriously the distinction between persons; (b) the account does not guarantee that the principles of justice will be derived from it; (c) the notion of impartiality in the account is the wrong one, since it does not define impartiality from the standpoint of the litigants themselves; (d) the account would offer a comprehensive, rather than a political, form of liberalism. The narrow aim of the article is to demonstrate that Adam Smith's impartial spectator account can rise to Rawls's challenges. The broader aim is to demonstrate that the impartial spectator account offers the basis for a novel and alternative framework for developing principles of justice, and does so in the context of a political form of liberalism.
The Demandingness of Individual Climate Duties: A Reply to Fragnière
Authors: Hickey Colin 
Published: January 2021

AbstractIn this article, I respond to Augustin Fragnière's recent attempt to understand the demandingness of individual climate duties by appealing to the difference between “concentrated” harm and “spread” harm and the importance of “moral thresholds”. I suggest his arguments don't succeed in securing the conclusion he is after, even from within his own commitments, which themselves are problematic. As this is primarily a critical project, the upshot of this discussion is that if there is a defensible way to justify the intuition that the duty to reduce emissions can't be overly demanding, it has to be found elsewhere.
Precision planting impacts on winter cereal rye growth, nutrient uptake, spring soil temperature and adoption cost
Authors: Sadeghpour Amir , Adeyemi Oladapo , Hunter Dane , Luo Yuan , Armstrong Shalamar 
Published: January 2021

AbstractGrowing winter cereal rye (Secale cereale) (WCR) has been identified as an effective in-field practice to reduce nitrate-N and phosphorus (P) losses to Upper Mississippi River Basin, USA. In the Midwestern USA, growers are reluctant to plant WCR especially prior to corn (Zea mays L.) due to N immobilization and establishment issues. Precision planting of WCR or ‘skipping the corn row’ (STCR) can minimize some issues associated with WCR ahead of corn while reducing cover crop seed costs. The objective of this study was to compare the effectiveness of ‘STCR’ vs normal planting of WCR at full seeding rate (NP) on WCR biomass, nutrient uptake and composition in three site-yrs (ARC2019, ARC2020, BRC2020). Our results indicated no differences in cover crop dry matter biomass production between the STCR (2.40 Mg ha−1) and NP (2.41 Mg ha−1) supported by similar normalized difference vegetative index and plant height for both treatments. Phosphorus, potassium (K), calcium (Ca) and magnesium (Mg) accumulation in aboveground biomass was only influenced by site-yr and both STCR and NP removed similar amount of P, K, Ca and Mg indicating STCR could be as effective as NP in accumulating nutrients. Aboveground carbon (C) content (1086.26 kg h−1 average over the two treatments) was similar between the two treatments and only influenced by site-yr differences. Lignin, lignin:N and C:N ratios were higher in STCR than NP in one out of three site-yrs (ARC2019) indicating greater chance of N immobilization when WCR was planted later than usual. Implementing STCR saved $8.4 ha−1 for growers and could incentivize growers to adopt this practice. Future research should evaluate corn response to STCR compared with NP and assess if soil quality declines by STCR practice over time.