bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlates of Non-Participation in Mass Drug Administration Against Neglected Tropical Diseases in the Assin North Municipality in the Central Region of Ghana
Authors: Akazili James , Agoringya Isaiah , Kanmiki Edmund Wedam , Woode Maame , Alomatu Bright , Osei-Atweneboa Mike , Thomson Rachael , Selormey Pamela , Khan Jahangir A. M. 
Published: March 2021

Abstract
Background: Many countries in Africa are making progress towards reducing the incidence of Neglected Tropical Diseases (NTDs) and possibly eliminating them completely. Through the accepted global strategy of Mass Drug Administration (MDA), the COUNTDOWN project1 has made significant attempts through a partnership with the Ghana Health Service to reduce the incidence and impact of NTDs particularly Schistosomiasis (SCH), Soil Transmitted Helminths (STH), Onchocerciasis (OV), and Lymphatic Filariasis (LF) in Ghana. However, elimination can be achieved only when the key players including the community members comply with the programme guidelines and requirements by participating in MDA campaigns against NTDs. The objective of the paper is to examine the factors influencing community members’ participation in MDA programs that seeks to bring the services of NTDs prevention to the doorstep of individuals. Methods: We used a population-based survey data of 1,034 people from 296 households collected in the Assin North Municipality in the Central Region of Ghana. First, chi-square test was used to test the association of socio-economic factors and participation in MDAs. Subsequently, we ran a multilevel logistic regression model to estimate the association of factors that influence non-participation in MDA by community members. Results: Nearly a quarter of respondents had once suffered from STH (22.5%) and a small fraction from bilharzia (7.4), river blindness (1.1%), and nobody suffered from LF. Although almost all respondents (97%) had ever heard of MDA campaign, 22% of respondents missed or did not participate in a MDA program. Factors that were found to correlate with non-participation in MDA programs are marital status and previously receiving tablets from a MDA campaign. Conclusion: Results showed that MDA participation by community members is relatively high and thus Ghana’s efforts at eliminating NTDs through MDA is on course. However, continues public education is required to maintain high participation and possibly improve upon it. 1The project looks at the parasitological, epidemiological as well as the socio-economic factors that influence the acceptance, effectiveness, efficiency and equity impact of scale-up from a health systems approach
ALKBH5-Mediated M6a-Demethylation Of USP1 Regulated T-Cell Acute Lymphoblastic Leukemia Cell Glucocorticoid Resistance by Stabilizing Aurora B
Authors: Gong Hongtao , Liu Liu , Cui Lina , Ma Hongyan , Shen Liyun 
Published: March 2021

Abstract
Recent studies have evidenced that ubiquitin-specific proteases (USPs) are associated with the occurrence and drug resistance of T-cell acute lymphoblastic leukemia (T-ALL). N6-methyladenosine (m6A) demethylase AlkB homolog 5 (ALKBH5) exerts a carcinogenic effect in human cancers and improves the mRNA stability of USPs. Whether ubiquitin specific protease 1 (USP1) controls chemoresistance in T-ALL is unknown. Our study demonstrated that USP1, Aurora kinase B (Aurora B) and ALKBH5 levels were highly expressed in glucocorticoid (GC)-resistant T-ALL patients and cells (CEM-C1). High expression of USP1 was correlated to the poor prognosis of T-ALL patients. Silencing USP1 increased CEM-C1 cell sensitivity to dexamethasone (Dex), reduced cell invasion, promoted cell apoptosis, and ameliorated glucocorticoid receptor (GR) expression. USP1 mediated T-ALL chemoresistance by interacting with Aurora B. Overexpression of USP1 reversed the promotive effects of Aurora B inhibitor on the sensitivity of CEM-C1 cells to Dex, cell apoptosis and GR level and the inhibition effect on cell invasion. Downregulation of ALKBH5 reduced the levels of USP1 and Aurora B, facilitated CEM-C1 cell sensitivity to Dex, apoptosis and GR expression, suppressed cell invasion. However, overexpression of USP1 reversed all the effects of ALKBH5 on CEM-C1 cells. In vivo results showed that tail vein injection of sh-USP1 resulted in a significant prolongation of mouse survival and maintained the normal weight of mice compared to the Dex group, reduced USP1 expression and facilitated GR expression. In conclusion, downregulation of USP1 ameliorated glucocorticoid resistance of T-cell acute lymphoblastic leukemia cells through suppressing Aurora B expression and elevating GR level.
The interplay of Malm carbonate permeability, gravity-driven groundwater flow, and paleoclimate – implications for the geothermal field and potential in the Molasse Basin (Southern Germany), a foreland-basin play
Authors: Schintgen Tom Vincent , Moeck Inga Sigrun 
Published: March 2021

Abstract
The Molasse Basin in Southern Germany is part of the North Alpine Foreland Basin and hosts the largest accumulation of deep geothermal production fields in Central Europe. Despite the vast development of geothermal energy utilization projects especially in the Munich metropolitan region, the evolution of and control factors on the natural geothermal field are still debated. Especially seismic and deep well data from extensive oil and gas exploration in the Molasse Basin led to conceptual hydrogeological and thermal-hydraulic models. Corrected borehole-temperature data helped to constrain subsurface temperatures by geostatistical interpolation and facilitated the set-up of 3D temperature models. However, within the geothermally used Upper Jurassic (Malm) carbonate aquifer, temperature anomalies such as the Wasserburg Trough anomaly to the east of Munich and their underlying physical processes are yet poorly understood. From other foreland basins like the Alberta Basin in Western Canada, it is known that climate during the last ice age has a considerable effect even on subsurface temperatures up to two kilometres depth. Therefore, we study the impact of paleoclimatic changes on the Molasse Basin during the last 130 ka including the Würm glaciation. We consider the hydraulic and thermal effects of periglacial conditions like permafrost formation and the impact of the numerous glacial advances onto the Molasse Basin. The major difference between the thermal-hydraulic regime in the western and eastern parts of the Southern German Molasse Basin are delineated by calculating two contrasting permeability scenarios of the heterogeneously karstified Malm carbonate aquifer. Thermal-hydraulic modelling reveals the effect of recurrent glacial periods on the geothermally drillable subsurface, which is minor compared to the effect of permeability-related, continuous gravity-driven groundwater flow as a major heat transport mechanism. Practically, the results might help to reduce the exploration risk for geothermal energy projects in the Molasse Basin. More importantly, this study serves as a reference for the comparison and understanding of the interplay of high permeability aquifers, gravity-driven groundwater flow and paleoclimate in other orogenic foreland basins worldwide.
WITHDRAWN: Zn(II) Metal-organic Framework Nanoparticles: Synthesis, Characterization and Application as Optical Biosensor for Prostate-Specific Antigen
Authors: Basaleh Amal S. , El-Sheikh S. M. 
Published: March 2021

Abstract
PSA, abbreviated of “Prostate-Specific Antigen” is widely used as a considered a significant cancer biomarker for diagnosing prostate cancer. Improvement of a fast, facile, and less cost with high accurate/sensitive/selective methodologies for the PSA determination is stock-still a challenge. In this work, we reported a simple biosensor based on a Zn(II) metal-organic framework nanoparticles (Zn-MOF-NPs) derived from reaction of zinc acetate with nano organic linker. The structure, morphology, and physicochemical properties of the prepared Zn(II)-MOF-NPs were definite using various spectroscopic and microanalytical tools as SEM-EDX, HR-TEM, XRD, XPS, elemental analysis, FT-IR, UV-vis spectroscopy, mass spectroscopy, thermogravimetric Analysis (DSC/TGA), and photoluminescence (PL). Obviously, the results revealed that the Zn(II)-MOF-NPs is chemical stable, highly selective and sensitive to PSA, without interferences with other common interfering analytes. The detection limit for PSA was 0.145 fg/mL, in a wide-linear range of concentrations (0.1 fg/mL-20 pg/mL), with a correlation coefficient 0.983. The Zn(II)-MOF-NPs was successfully used as an up-and-coming biosensor for PSA-monitoring and quantification in biological real samples (plasma/whole blood/serum) at clinical target concentration levels. Moreover, the present approach will help the human-beings from the hazard’s prostatic cancer through early discovery and diagnosis process via the detection of PSA at low limits of concentrations. Meantime, the interaction mechanism between the Zn(II)-MOF-NPs and PSA was well studied and investigated.
Malaria in Haiti: A Descriptive and Temporal Study from 2009 to 2018.
Authors: Jules Jean Ricardo , Alencar Jeronimo , Baptiste Ernst Jn , Suárez-Mutis Martha Cecília , Albuquerque Hermano Gomes , Rosa-Freitas Maria Goreti , Raccurt Christian , Silva-do-Nascimento Teresa Fernandes 
Published: March 2021

Abstract
Background

Haiti is one of the Caribbean countries where malaria still persists. Malaria occurs throughout the country at altitudes below 600 meters. More than 99% of the malaria cases are caused by Plasmodium falciparum and the main vector is Anopheles albimanus. This paper aims to describe the epidemiological profile of malaria in Haiti between 2009 and 2018.
Methods

We analyzed information on malaria cases reported by both the Health Ministry of Haiti (Ministère de la Santé Publique et de la Population-MSPP) and the World Health Organization (WHO) during the study period.
Results

Between 2009 and 2018, a total of 232,479 malaria cases were reported by the MSPP. There was an increase in the incidence of malaria in the country in 2010 followed by a decrease in 2011. Due to efforts made by Haiti over the past decade to reduce malaria by 2020, malaria incidence has declined from 60,130 cases in 2010 to 8,978 cases in 2018. We verified that the MSPP and the WHO data are conflicting in relation to the number of cases reported. However, the results from both data sets presented the same malaria trend in Haiti from 2009 to 2018. The results also show the endemicity of the disease throughout Haiti, both in rural and urban areas, especially along the coast.
Conclusion

This work emphasizes the need to promote official data collection and analyses and the application of epidemiological surveillance of malaria for a better knowledge about the real impact of malaria on the Haitian population aiming more appropriate interventions.
Luteorhabdos pelagi gen. nov., sp. nov., a novel member of the family Flavobacteriaceae, isolated from the West Pacific Ocean
Authors: Ren Wen-Ting , Meng Fan-Xu , Guo Li-Li , Sun Li , Xu Xue-Wei , Zhou Peng , Wu Yue-Hong 
Published: March 2021

Abstract
Gram-stain-negative, aerobic and yellow-pigmented bacterium, designated A3-108T, was isolated from seawater of the West Pacific Ocean. Cells were non-motile and rod-shaped, with carotenoid-type pigments. The strain A3-108T grew at pH 6.0-8.5 (optimum 6.5) and 15–40℃ (optimum 28℃), in the presence of 0.5–10% (w/v) NaCl (optimum 1.0%). It possessed the ability to produce H2S. Based on the 16S rRNA gene analysis, strain A3-108T exhibited highest similarity with Aureisphaera salina A6D-50T (90.6%). Phylogenetic analysis shown that strain A3-108T affiliated with the family Flavobacteriaceae and represented an independent lineage. The principal fatty acids were iso-C15:0, iso-C17:0 3-OH, iso-C15:1 G and summed feature 3 (C16:1ω7c and/or C16:1ω6c). The sole isoprenoid quinone was MK-6. The major polar lipids were phosphatidylethanolamine, one unidentified aminophospholipid, one unidentified aminolipid and one unidentified lipid. The ANIb, in silico DDH and AAI values among the genomes of strain A3-108T and the reference strains were 67.3–71.1%, 18.7–22.1% and 58.8–71.4%, respectively. The G + C content was 41.0%. Differential phylogenetic distinctiveness, chemotaxonomic differences as well as phenotypic properties revealed that strain A3-108T represented a novel genus and species of the family Flavobacteriaceae, for which the name Luteorhabdos pelagi gen. nov., sp. nov. is proposed (type strain, A3-108T = CGMCC 1.18821T = KCTC 82563T).
Mathematical study on a dynamical predator-prey model with constant prey harvesting and proportional harvesting in predator
Authors: Mortuja Md Golam , Chaube Mithilesh Kumar , Kumar Santosh 
Published: March 2021

Abstract
A dynamical predator-prey model with constant prey harvesting, proportional harvesting in predator has been studied. The square root func- tional response also has been incorporated in the system to describe the prey herd behaviour, assuming the average handling time is zero. The existence and the local stability of equilibria of the system have been discussed. It is examined that, two types of bifurcation occur in the system. The two types of bifurcations have been analyzed, and it has been found by analyzing the saddle-node bifurcation that, there is a maximum sustainable yield. It is ob- served that if harvesting rate is greater than the maximum sustainable yield, the prey population abolish from the system and then extinction of the preda- tor population happen. But if harvesting rate is lesser than the maximum sustainable yield, the extinction of the prey population can not be possible. By analyzing the Hopf bifurcation, it is obtained that, there exists an unstable limit cycle around the interior equilibrium point. Several numerical simulations are performed to check the results.
Application of ethical leadership and workers’ performance: A perspectives from public and private owned enterprises
Authors: OLANNYE Anthonia Awele 
Published: March 2021

The main objective of the study was to determine the rationale of ethical leadership in public and privately-owned enterprises. It involved two public sectors and two private sector enterprises, which comprised 221 respondents from the staff and management of the enterprises as the sample size for the study. The survey research method was used in gathering information from respondents. A stratified sampling technique was adopted for the study. A validated structured questionnaire was used for data collection. The statistical techniques adopted for processing the data and testing the hypotheses for this study compared mean using independent t-test via the use of statistical package for social science (SPSS) software version 2 1. Descriptive statistics and frequency analysis were used. The mean response was tested using a t-test. The findings of the study revealed that there is no significant difference in ethical leadership between the public and private enterprises given that the variables revealed thus (Sig. = .728, P> 0.05) and (Sig. .238, P> 0.05). The study concluded that the leadership of the public and private enterprise should have the ethical values, interpersonal qualities and capabilities to carry out the different tasks as needed by the organizations.
ŞEFAATLİ (YOZGAT) DOĞUSU SU KAYNAKLARININ HİDROJEOLOJİK VE HİDROJEOKİMYASAL İNCELEMESİ
Authors: ŞENER Şehnaz , ŞENER Erhan 
Published: March 2021

Bu çalışmada, Yozgat ili, Şefaatli ilçesi doğusu yüzey ve yeraltısularının hidrojeolojik ve hidrojeokimyasal özellikleri incelenmiştir. Bölgede yüzeyleyen jeolojik birimler hidrojeolojik özelliklerine göre Akifer-1, Akifer-2, Akitard ve Aküfüj olmak üzere dört ayrı grupta incelenmiştir. Mayıs (2019) döneminde yapılan yeraltısuyu seviye ölçüm sonuçlarına göre bölgede yeraltısuyu derinlikleri 3,22 m ile 20 m arasında, yeraltısuyu seviye değerleri ise 945,25 m ile 1045,05 m arasındadır. Bölgede, yeraltısuyu akımının, güneydoğudan kuzeybatıya doğru olduğu belirlenmiştir. Aynı dönemde yeraltısuyu ve yüzeysularından alınan su örneklerinin hidrojeokimyasal özellikleri, su kalitesi ve kullanım özellikleri belirlenmiştir. Buna göre su örnekleri Na-Ca-HCO3, Ca-Mg-HCO3 ve Ca-Mg-HCO3-SO4’lı sular fasiyesinde yer almaktadır.
Su örneklerin kimyasal analiz sonuçlarına göre yeraltısularının Al ve As parametreleri bakımından, yüzey sularının ise Al, As, Mn ve Fe parametreleri bakımından içme suyu olarak kullanıma uygun olmadığı belirlenmiştir. Su kaynaklarında söz konusu parametrelerin artışı kaya-su etkileşimi ile gelişmektedir. Ayrıca, bölgedeki tarımsal faaliyetler ile ilişkili olarak yeraltısuyu örneklerinin NO3 değerlerinin içme suyu limit değerlerin üzerinde olduğu belirlenmiştir.
МИГРАНТСКА И ИЗБЕГЛИЧКА КРИЗА: КОМПАРАТИВНИ ПРИКАЗ ИЗВЕШТАВАЊА ДНЕВНИХ ЛИСТОВА БЛИЦ, ПОЛИТИКА И КУРИР
Authors: Aleksić Dušan , Stamenković Ivana 
Published: March 2021

Intensive migrations during the last years of the 20th century and in the beginning of the 21st century are an important part of modern societies which are becoming multicultural. While information, ideas and people cross countries’ borders all the time, and term „nation“ is becoming outdated in new communication universe, the foundations of identity are becoming weak, unstable and subject to change. In crisis, media reporting about groups which are not culturally close to the native population significantly influences the public opinion creating, since direct contacts with such groups are limited and rare. Besides, the question arises to what extent such reporting is subject to the ethical codes. In this paper, media reporting about recent European migrant and refugee crisis was analyzed. The paper is primarily focused on media representation of migrants and refugees which was analyzed through several aspects: frequency of texts about migrants and refugees, the analysis of genres, titles, visual presentation, respect of journalistic ethics as well as examination of rhetorical, stylistic and manipulative means that were used. All texts about migrant and refugee crisis published over a period of two weeks on three informative web-portals – „Blic“, „Kurir“ and „Politika“ were analyzed. The first analyzed week was from June 1st to September 7th, 2015, while the second week was from March 1st to March 7th, 2017. The goal of this comparative analysis of media texts was to determine possible differences in the way migrants and refugees are portrayed in media texts. The main goal was to determine diferences between three informative portals in terms of emphasis certain aspects of migrant and refugee crisis as well as in terms of emphasis certain characteristics of this social group.
DINÂMICA ESPACIAL DA PANDEMIA DE COVID-19 ATRAVÉS DE MAPAS ANAMÓRFICOS DO ESTADO DO RIO DE JANEIRO
Authors: Ferreira Patricia Regina Pires , De Sousa Gustavo Mota , Marino Tiago Badre 
Published: March 2021

O presente trabalho busca representar os casos, óbitos e taxas de letalidade do COVID-19 em regiões de governo do Estado do Rio de Janeiro por anamorfismo. A técnica de anamorfismo consiste na construção de cartogramas que deformam os limites substituindo as escalas métricas por escalas fracionais. O objetivo do trabalho é analisar a distribuição do COVID-19 ao longo dos meses de abril a agosto de 2020, utilizando o ScapeToad para essas representações. ScapeToad é um software livre, que permite a criação de mapas anamórficos, também chamados de cartogramas. A metodologia aplicada foi a disseminação da doença nos municípios do Estado com os números absolutos de casos confirmados, óbitos e a taxa de letalidade confrontada com a estimativa populacional indicada pelo IBGE. Os resultados mostraram que a disseminação dos dados começou na Região Metropolitana e avançou pelas maiorescidades do interior.
Palavras-chave: Anamorfismo, Cartograma, População, COVID-19.SPATIAL DYNAMICS OF COVID-19 PANDEMIC THROUGH ANAMORFPHIC MAPS OF THE STATE OF RIO DE JANEIROAbstract: The present work seeks to represent the cases and deaths of COVID-19 in government regions of the State of Rio de Janeiro due to anamorphism. The objective of the work is to analyze the distribution of COVID-19 from April to August 2020, using ScapeToad for these representations. ScapeToad is free software, which allows the creation of anamorphic maps, also called cartograms. The methodology applied was the spread of the disease in the municipalities of the State with the absolute numbers of confirmed cases and deaths confronted with the population estimate indicated by IBGE. The results showed that the dissemination of data began in the Metropolitan Region and advanced through the largest cities in the interior.
Keywords: Anamorphism, Cartogram, Population, COVID-19.DINÁMICA ESPACIAL DE LA PANDEMIA DE COVID-19 A TRAVÉS DE MAPAS ANAMÓRFICOS DEL ESTADO DE RÍO DE JANEIRO
Resumen: El presente trabajo busca representar los casos y muertes de COVID-19 en regiones gubernamentales del Estado de Río de Janeiro por anamorfismo. El objetivo del trabajo es analizar la distribución de COVID-19 de abril a agosto de 2020, utilizando ScapeToad para estas representaciones. ScapeToad es un software gratuito que permite la creación de mapas anamórficos, también llamados cartogramas. La metodología aplicada fue la propagación de la enfermedad en los municipios del Estado con los números absolutos de casos confirmados y defunciones confrontados con la estimación poblacional indicada por el IBGE. Los resultados mostraron que la difusión de datos se inició en la Región Metropolitana y avanzó por las ciudades más grandes del interior.
Palabras clave: Anamorfismo, Cartograma, Población, COVID-19.
Impact of Globalization on Socioeconomic and Health Conditions a Quantitative Study of Adivasis
Authors: Lal B. Suresh 
Published: March 2021

The process of globalisation has made an unprecedented change in indigenous people's lives worldwide. However, the degree of exploitation and marginalisation vary from State to states and tribal group to group. It examines that younger age group is more than 40%, the majority of Adivasis are illiterates. More than 70 per cent of samples are male and married, and they follow a nuclear family system. Fifty-three per cent of Adivasis are residing in small huts, their religion is Hindu, and they speak the Telugu language. Sixty per cent of respondents are cultivator with below three acres of land, and their annual income is below 14,000/ rupees. It shows that majority of Adivasis are in poverty. Twenty-three per cent of the respondent is suffering from Anaemia health problems, followed by 19 per cent of Blood Pressure, 15 per cent Diabetes, 13 per cent Tuberculosis, Nine per cent Gynecological problems, in the study area. The globalisation has adversely impacted socio-economic aspects, including marriage, dressing patterns, and food habits of Adivasis in the study area of Telangana State, India.
role and significance of collegiality and unity of command as a principle of organization and activity of executive authorities in Russia
Authors: Goncharov Vitaly Viktorovich , Mikhaleva Tatiana N. , Vasilevich Grigory A. , Balashenko Sergey A. , Pukhov Artem A. , Zalesny Jacek 
Published: March 2021

This article is devoted to the analysis of the problems of implementing such a principle of organization and activity of executive authorities in the Russian Federation as collegiality and unity of command. The authors identified the main shortcomings and imbalance in the implementation of the principle of collegiality and unity of command as the main organizational and legal forms of activity of executive authorities in modern conditions, and also developed proposals to eradicate imbalances in the work of collective and single-executive bodies of executive power.