bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Stable Population Code for Attention in Prefrontal Cortex Leads a Dynamic Attention Code in Visual Cortex
Authors: Snyder Adam C. , Yu Byron M. , Smith Matthew A. 
Published: September 2021

Attention often requires maintaining a stable mental state over time while simultaneously improving perceptual sensitivity. These requirements place conflicting demands on neural populations, as sensitivity implies a robust response to perturbation by incoming stimuli, which is antithetical to stability. Functional specialization of cortical areas provides one potential mechanism to resolve this conflict. We reasoned that attention signals in executive control areas might be highly stable over time, reflecting maintenance of the cognitive state, thereby freeing up sensory areas to be more sensitive to sensory input (i.e., unstable), which would be reflected by more dynamic attention signals in those areas. To test these predictions, we simultaneously recorded neural populations in prefrontal cortex (PFC) and visual cortical area V4 in rhesus macaque monkeys performing an endogenous spatial selective attention task. Using a decoding approach, we found that the neural code for attention states in PFC was substantially more stable over time compared with the attention code in V4 on a moment-by-moment basis, in line with our guiding thesis. Moreover, attention signals in PFC predicted the future attention state of V4 better than vice versa, consistent with a top-down role for PFC in attention. These results suggest a functional specialization of attention mechanisms across cortical areas with a division of labor. PFC signals the cognitive state and maintains this state stably over time, whereas V4 responds to sensory input in a manner dynamically modulated by that cognitive state.SIGNIFICANCE STATEMENTAttention requires maintaining a stable mental state while simultaneously improving perceptual sensitivity. We hypothesized that these two demands (stability and sensitivity) are distributed between prefrontal and visual cortical areas, respectively. Specifically, we predicted attention signals in visual cortex would be less stable than in prefrontal cortex, and furthermore prefrontal cortical signals would predict attention signals in visual cortex in line with the hypothesized role of prefrontal cortex in top-down executive control. Our results are consistent with suggestions deriving from previous work using separate recordings in the two brain areas in different animals performing different tasks and represent the first direct evidence in support of this hypothesis with simultaneous multiarea recordings within individual animals.
Intraoperative study of the functional perforasome - an experimental model
Authors: Nedu Maria-Eliza , Georgescu Alexandru Dan Valentin 
Published: September 2021

Background and aims. The aim of this study is to find the most suitable protocol based on an animal experimental model, through the use of a fluorescent dye, determining also its minimal concentration needed to stain the skin after arterial injection, in order to be evidence the functional perforasome by visual examination.
Methods. Methylene blue solution was used in order to determine the territory vascularized by one perforator on fresh cadavers in many studies which introduced, as a final result, the concept of perforasome. One of the most frequent complications of perforator flaps is partial flap necrosis which could be avoided by correctly assessing pre-operatively the functional perforasome surface.
Two groups of seven rats were used in order to establish a proper surgical protocol to evaluate the functional perforasome in vivo by injecting the dye. Also, the minimal concentration for methylene blue was experimentally determined.
Results. The direct injection into the femoral artery of the proper concentration of dye, 1mM for methylene blue and the clamping of all the branches except the medial branch of the superficial epigastric artery is a reliable model to study the functional perforasome.
Conclusions. Our study demonstrates that the intraoperative assessment with fluorescent dye of the functional perforasome by intra-arterial injection of methylene blue is an easy, affordable and very efficient method to reduce the number of partial necrosis of the perforator flaps.
Bias in estimates of mb at small magnitudes
Authors: Evernden J. F. , Kohler W. M. 
Published: September 2021

abstract
A possibly significant factor in application of an identification criterion such as MS:mb is systematic bias in mb magnitude estimates at small magnitudes due to a variety of factors. Magnitude bias is the difference in magnitude value, positive or negative, between an observed network-based magnitude value and the expected magnitude value if all stations of the network had detected the event at high signal-to-noise ratio. This paper constitutes a partial study of the general problem; it evaluates the bias effects expected from both conceptual and operational networks when using parameters for noise and signal levels and standard deviations derived from observations, and when correcting observed station mb values solely via a simple parameter station correction factor.
The analysis shows that any bias effects on mb inherent in any operational or potential worldwide network are so small as to have negligible effect on use of an MS:mb discriminant.
Cause of amblyopia in adult patients: a cross-sectional study
Authors: Waheed Abdul , Kumari Nitika , Ali Jamshed , Dubey Gaurav , Kumari Vibha , Kumari Ragni , Shahid Yasmeen 
Published: September 2021

Background: Amblyopia has been defined as a decrease of visual acuity for which no causes can be detected by the physical examination of the eye, caused by vision deprivation or abnormal binocular interaction. This study aims to determine the cause of amblyopia in adult patients at HAHC hospital South Delhi.Methods: This is a cross-sectional study conducted over a period from January 2018 till March 2018 among the patients in HAHC hospital. A comprehensive eye examination was used to analyse the visual condition.Results: Amblyopia was diagnosed in 42 participants, with age-and gender-adjusted prevalence of 3.2%. Of these, 1.9% were unilateral cases, and 1.3% were bilateral cases. A major cause of amblyopia in this population was a refractive error, hence using spectacle correction and vision therapy for its initial management.Conclusions: This study has provided causes of amblyopia in an adult population. Amblyopia is a frequent cause of lifelong unilateral visual impairment.
Emerging problem to health care workers in form of virus and fungus combo: a tertiary care centre experience
Authors: Beniwal Vimla , Beniwal Surender Kumar , Manoher Jaishri Murli , Jat Hari Ram 
Published: September 2021

Background: Rhino-orbital-cerebral mucormycosis has reached epidemic proportion during second wave of COVID-19 pandemic in India. In this study we aimed to understand the demographics, presentation, temporal sequence, risk factors and outcomes to undertake measures for prevention and treatment and benefit of administering liposomal amphotericin via retrobulbar injection in addition to systemic antifungals in the setting of rhino-orbital-mucormycosis.Methods: Study of patients with COVID-19-associated mucormycosis managed or co-managed by ophthalmologists in our centre from April 2021 to June 2021.Results: Male predominance and more than 75% associated with COVID-19 infection. Common risk factors associated were DM and corticosteroids use. Unilateral involvement was common (82.4%). Most common primary symptom and sign of ROCM is orbital/facial pain (68.4%) and ptosis (84.2 %) respectively. retro bulbar amphotericin B injections had slight improvement in vision (25%), ptosis (37.5%) and extra ocular movement (25%) with few complications. Surgical management were PNS debridement (42.1%), exenteration added in 17.5 % and with above procedure additional maxillectomy needed in 14%. 22.8 % cases were succumbed by disease while 40.1 % of live patients needed orbital exenteration.Conclusions: ROCM has visible signs and symptoms, help us in early diagnosis as compared to mucormycosis at other anatomical sites and should be known to all ophthalmologists. Early diagnosis by involving root level health worker and creation of standard treatment guideline on emerging heath problem is an urgent need.
Prevention of hypoparathyroidism with the use of calcium-rich foods in the total thyroidectomy pre-operative period
Authors: Segal Marcelo Jacques , De Aquino Jose Luis Braga , Merhi Vania Aparecida Leandro , De Camargo Jose Gonzaga Teixeira , Pizzinato Paula Srebernich , Ramos Joao Paulo Zenun , Delatti Fernando De Almeida , Rocha Felipe Couto Ferreira , Ferruccio Aline Akel 
Published: September 2021

<p class="abstract"><strong>Background:</strong> Transient hypocalcemia after total thyroidectomy (TT) is a common surgical complication. Authors used calcium supplements in different doses and periods, mainly after TT to try to avoid hypocalcemia. Indistinct use has been challenged due to complications. Currently, the risk of hypocalcemia was assessed by measuring parathormone (PTH) after TT; however, without a consensus on the best time and amount to consider. The objectives of this study were to evaluate the incidence of hypoparathyroidism with the use of calcium-rich foods in the pre-operative period of TT, followed by a measurement of PTH performed 12 hours after such procedure</p><p class="abstract"><strong>Methods:</strong> A preliminary study with 31 patients earmarked for TT. Patients were divided into two groups: (A) without calcium-rich foods intake in the TT pre-operative period; and (B) with the intake of calcium-rich foods, in the TT pre-operative period. These foods composing different menus have been suggested, based on the need for daily calcium intake, according to the age group and nutritional data of the Dietary reference intake (DRI). Beginning of the use of these foods has been standardized as being seven days before surgery, due to the slower calcium intestinal absorption process. </p><p class="abstract"><strong>Results:</strong> Group B, when compared to A, showed a significant difference between PTH values, before and after surgery (p value &lt;0.001).</p><p class="abstract"><strong>Conclusions:</strong> Calcium-rich foods intake in the conditions reported may be associated with lower rates of hypoparathyroidism.</p>
Comparative study of outcomes of type 1 tympanoplasty with and without anterior tucking
Authors: Thingujam Sonee , Poduval Jayita 
Published: September 2021

<p class="abstract"><strong>Background:</strong> Type-1 tympanoplasty is the functional restoration of the normal middle ear by repairing the tympanic membrane (TM). Different techniques are still evolving to devise a way to give optimal graft uptake and hearing improvement with minimal instrumentation. Various studies have been done to assess the role of anterior tucking in type-1 tympanoplasty and to assess its superiority over other methods in repairing subtotal perforations and large perforations involving the anterior quadrant.</p><p class="abstract"><strong>Methods:</strong> This study was done to compare the outcomes of endoscopic type-1 tympanoplasty with and without anterior tucking. 60 cases of chronic otitis media (COM) mucosal type were divided into 2 groups of 30 patients each. Group 1 underwent endoscopic type-1 tympanoplasty with anterior tucking and group 2 underwent endoscopic type-1 tympanoplasty without anterior tucking. The outcomes were evaluated after 6 months and compared in terms of graft uptake and hearing gain.</p><p class="abstract"><strong>Results:</strong> The mean air-bone gap improvement was 13.16±2.65 in group 1 and 12.90±3.78 in group 2, which had statistically insignificant differences indicating similar hearing outcomes in both the groups. 96.7% successful graft uptake was achieved in group 1 and 90% in group 2, showing statistically insignificant differences indicating similar graft uptake rates in both the groups.</p><p><strong>Conclusions:</strong> Anterior tucking with endoscopic type-1 tympanoplasty could provide good graft support and efficient hearing improvement but cannot be labelled as a mandatory step in repairing subtotal perforations or large perforations involving anterior quadrant as the outcomes are comparable to the endoscopic type-1 tympanoplasty done without anterior tucking. </p>
Constraining the body mass range of Anzu wyliei using volumetric and extant-scaling methods
Authors: Atkins-Weltman Kyle , Snively Eric , O'Connor Patrick 
Published: September 2021

The ability to accurately and reliably estimate body mass of extinct taxa is a vital tool for interpreting the physiology and even behavior of long-dead animals. For this reason, paleontologists have developed many possible methods of estimating the body mass of extinct animals, with varying degrees of success. These methods can be divided into two main categories: volumetric mass estimation and extant scaling methods. Each has advantages and disadvantages, which is why, when possible, it is best to perform both, and compare the results to determine what is most plausible within reason. Here we employ volumetric mass estimation (VME) to calculate an approximate body mass for previously described specimens of Anzu wyliei from the Carnegie Museum of Natural History. We also use extant scaling methods to try to obtain a reliable mass estimate for this taxon. In addition, we present the first digital life restoration and convex hull of the dinosaur Anzu wyliei used for mass estimation purposes. We found that the volumetric mass estimation using our digital model was 216-280kg, which falls within the range predicted by extant scaling techniques, while the mass estimate using minimum convex hulls was below the predicted range, between 159-199 kg . The VME method for Anzu wyliei strongly affirms the predictive utility of extant-based scaling. However, volumetric mass estimates are likely more precise because the models are based on comprehensive specimen anatomy rather than regressions of a phylogenetically comprehensive but disparate sample.
Determining the key success factors in the organization of BP Tapera
Authors: Soeprapto Dedy Dewanto 
Published: September 2021

The purpose of this paper is to determine the Key Success Factors in the operationalization of BP. Tapera (Public Housing Savings Implementing Agency), so that solutions to the challenges faced by institutions in the future will be found, as well as ways to achieve successful performance. As results of external analysis research, showing several key success factors, including high economic growth, large population, implementation of mandatory Tapera membership, high yielding Tapera fund accumulation, transparent and accountable Tapera administration principles, the culture of mutual cooperation and humanity, availability of adequate office/branch services, availability of integrated IT, Decrease Termination of Employment, Employment Increase, Price Stability, Equitable Development Results, Participant Awareness and Trust, Employer Support, Land Bank Availability. As a follow-up study, BP. Tapera must immediately develop and perform strategies to implement these key success factors.
Spatio-Temporal Variability of Malaria Infection in Chahbahar County, Iran: Association with the ENSO and Rainfall Variability
Authors: Nazemosadat Seyed Mohammad Jafar , Shafiei Reza , Ghaedamini Habib , Najjari Mohsen , Nazemosadat Zahra , Hatam Gholamreza 
Published: September 2021

Abstract
Malaria is one of the most widespread communicable diseases in the southeast of Iran particularly in Chahbahar County. Comprehensive understanding of the influence of climate on this disease is a key element for success in the environmental-based malaria elimination programs. After analyzing the spatio-temporal distribution of the disease, the relationships between the infection statistics and some important climate indices particularly the El Niño-Southern Oscillation (ENSO) and rainfall were investigated.The malaria statistics collected from various health centers were composited with the corresponding data of Southern Oscillation Index (SOI), ground-based meteorological records and satellite-based rainfall data. Non-parametric Mann-whitely test was applied to detect the significant difference between patient number between El Niño and La Niña and between the adopted wet and dry episodes. Patient number from highest to lowest was associated to summer, autumn, spring and winter, respectively. Plasmodium falciparum, Plasmodium vivax and other species were responsible for 22%, 75% and 3% of the sickness, respectively. While the outbreak of P. falciparum is in autumn; P. vivax is erupted in summer. When the epidemic statistics were collected from rural rather than urban areas, the effect of climate on the infection statistic was more obvious. Interpretation: For rural / urban areas, the infection statistics exhibited a significant decline / increase during El Niño episodes. In autumn, spring and winter, patient number has significantly increased / decreased during the dry / wet epochs, respectively. These relationships were, however, reversed during summertime of health indicators are rarely available for every population and period of interest, and available data.
Impact of Initialization Methods on the Predictive skill in NorCPM - An Arctic-Atlantic Case Study
Authors: Passos Leilane , Langehaug Helene , Årthun Marius , Eldevik Tor , Bethke Ingo , Kimmritz Madlen 
Published: September 2021

Abstract
The skilful prediction of climatic conditions on a forecast horizon of months to decades into the future remains a main scientific challenge of large societal benefit. Here we assess the hindcast skill of the Norwegian Climate Prediction Model (NorCPM) – for sea surface temperature (SST) and sea surface salinity (SSS) in the Arctic-Atlantic region – focusing on the impact of different initialization methods. We find the skill to be distinctly larger for the Subpolar North Atlantic than for the Norwegian Sea, and generally for all lead years analyzed. For the Subpolar North Atlantic, there is furthermore consistent benefit in increasing the amount of data assimilated, and also in updating the sea ice based on SST with strongly coupled data assimilation. The predictive skill is furthermore significant for at least two model versions up to 8-10 lead years with the exception for SSS at the longer lead years. For the Norwegian Sea, significant predictive skill is more rare; there is relatively higher skill with respect to SSS than for SST. A systematic benefit from more complex data assimilation approach can not be identified for this region. Somewhat surprisingly, skill deteriorates quite consistently for both the Subpolar North Atlantic and the Norwegian Sea when going from CMIP5 to corresponding CMIP6 versions. We find this to relate to change in the regional performance of the underlying physical model that dominates the benefit from initialization.
Urgent Care Study of the LumiraDx SARS-CoV-2 Ag Test for Rapid Diagnosis of COVID-19
Authors: Gresh Jared , Kisner Harold , DuChateau Brian 
Published: September 2021

Abstract
BackgroundTesting individuals suspected of SARS-CoV-2 infection is essential to reduce the spread of disease. The purpose of this study was to determine the false negativity rate of the LumiraDx SARS-CoV-2 Ag Test when utilized for testing individuals suspected of SARS-CoV-2 infection within 12 days of symptom onset. MethodsConcurrent swab samples were collected from patients suspected of SARS-CoV-2 infection by their healthcare provider within two different urgent care centers. One swab was tested using the LumiraDx SARS-CoV-2 Ag Test. Negative results in patients considered at moderate to high risk of SARS-CoV-2 infection were confirmed at a regional reference laboratory by PCR using the additional swab sample. ResultsFrom October 19, 2020 – January 3, 2021, a total of 2241 tests were performed using the LumiraDx SARS-CoV-2 Ag Test, with 549 (24.5%) testing positive and 1692 (75.5%) testing negative. A subset (800) of the samples rendering a negative LumiraDx SARS-CoV-2 Ag Test were also tested using a PCR-based test for SARS-CoV-2. Of this subset, 770 (96.3%) tested negative, and 30 (3.8%) tested positive. A cycle threshold (CT) was available for 17 of the 30 specimens that yielded discordant results, with an average CT value of 31.2, an SD of 3.0, and a range of 25.2–36.3. CT was >30.0 in 11/17 specimens (64.7%). ConclusionsThis study demonstrates that negative results obtained with the LumiraDx SARS-CoV-2 Ag Test had 96.3% agreement with PCR-based SARS-CoV-2 tests, with a low false negative rate of 3.8% when used in a community-based setting.
Human Weight Compensation with a Backdrivable Upper-Limb Exoskeleton: Identification and Control
Authors: VERDEL Dorian , Bastide Simon , Vignais Nicolas , Bruneau Olivier , Berret Bastien 
Published: September 2021

Abstract
Active exoskeletons are promising devices for improving rehabilitation procedures in patients and preventing musculoskeletal disorders in workers. In particular, exoskeletons implementing human limb’s weight support are interesting to restore some mobility in patients with muscle weakness and help in occupational load carrying tasks. The present study aims at improving weight support of the upper limb by providing a weight model considering joint misalignments and a control law including feedforward terms learned from a prior population-based analysis. Three experiments, for design and validation purposes, are conducted on a total of 65 participants who performed posture maintenance and elbow flexion/extension movements. The introduction of joint misalignments in the weight support model significantly reduced the model errors, in terms of weight estimation, and enhanced the estimation reliability. The introduced control architecture reduced model tracking errors regardless of the condition. Weight support significantly decreased the activity of antigravity muscles, as expected, but increased the activity of elbow extensors because gravity is usually exploited by humans to accelerate a limb downwards. These findings suggest that an adaptive weight support controller could be envisioned to further minimize human effort in certain applications.
Dissolution and Reprecipitation of Sulfur on Carbon Surface
Authors: Liu Jingdong , Zheng Yuanhui 
Published: September 2021

Abstract
Further understanding of the redox process of lithium polysulfides (PSs) on carbon surface is helpful to design Li/S batteries with better performance. “Shuttle mechanism” can explain the low coulomb efficiency and self-discharge of a Li/S battery, but it cannot explain the fact that battery performance is closely affected by electrolyte volume and sulfur load. This paper aims to reveal main redox process of PSs on surface of carbon by examining cathodic behavior with different electrolyte volume and sulfur load. SEM photos and Impedance Spectra of cathode before and after 1st discharge were compared, it was found that the discharge process is the continuous dissolution of sulfur composited with carbon into the electrolyte to form PSs, at the same time, PSs re-precipitates sulfur on the surface of cathode through disproportionation reaction to form a solid film. CV curves showed that the solid film passivates electrode, and the electrode is activated only when potential sweeps negatively and Li2S is generated. When lean electrolyte is used, there is fluctuation in CV curves, which proves that the dissolution-reprecipitation of sulfur is the main process of cathode. The discharge-charge curves of cathodes with different sulfur load were compared, it was found that there is wavy fluctuation in the discharge curve with high sulfur load, which proves again that the sulfur reaction dominates the electrode process.