bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID‐19 preparedness in aged care: A qualitative study exploring residential aged care facility managers experiences planning for a pandemic
Authors: Sunner Carla , Giles Michelle , Parker Vicki , Kable Ashley , Foureur Maralyn 
Published: July 2021

AbstractAims and ObjectivesThe study aims to understand the changing context of RACFs and the role of RACF managers in preparing to confront the COVID‐19 pandemic and to provide insights into how the use of visual telehealth consultation might be incorporated to assist with managing whatever might arise.DesignAn interpretive descriptive study design was employed, and data were collected using semi‐structured interviews conducted via telephone or videoconference. Purposive recruitment targeted clinical managers responsible for the COVID‐19 response in RACFs.MethodsRACF clinical managers were invited to discuss their responses to COVID‐19 including the management of RACF and staff. Semi‐structured interviews explored the COVID‐19‐related challenges, the response to these challenges and how telehealth might assist in overcoming some of these challenges. This study followed Thorne's (2008) three‐stage process of interpretive description. The COREQ checklist was used in preparing this manuscript.ResultsTwo main themes were identified. The first theme ‘keeping people safe’ was comprised of three subthemes; fear and uncertainty, managing the risks and retaining and recruiting staff. The second theme was ‘keeping people connected’, had two subthemes; being disconnected and isolated and embracing technology.ConclusionFindings from this study provide valuable insight into understanding the context and the challenges for RACFs and the staff as they attempt to keep residents safe and connected with healthcare providers and the outside world.Relevance to Clinical PracticeUnderstanding the experiences of RACF managers in preparing to respond to the pandemic will better inform practice development in aged care in particular the use of telehealth and safe practices during COVID‐19. Increased awareness of the challenges faced by RACFs during a pandemic provides policymakers with valuable insights for future planning of pandemic responses.
Non‐pharmacological interventions for pain management in patients with dementia: A mixed‐methods systematic review
Authors: Bao Zhuming , Landers Margaret 
Published: July 2021

AbstractAims and objectivesTo systematically identify, summarise and compare evidence from studies related to the non‐pharmacological interventions used to manage pain in patients with dementia. Secondly, this study aims to provide evidence on the effectiveness of non‐pharmacological interventions used to manage pain in patients with dementia.BackgroundThe number of people diagnosed with dementia is rising rapidly in the context of ageing. Pain is considered to be one of the most common neuropsychiatric symptoms of dementia. To date, little research has focused on non‐pharmacological interventions to manage pain in patients with dementia. Therefore, a systematic review on the non‐pharmacological interventions used to manage pain in patients with dementia and how effective these interventions are, is warranted.MethodThe extensive search strategy included electronic database searches for CINAHL, MEDLINE and PsycINFO from January 2009 to February 2020. A mixed‐methods systematic review was undertaken in accordance with the PRISMA statement and relevant papers were chosen based on inclusion criteria and quality assessment measures. Eligibility criteria defined the characteristics of inclusion studies using the PICO framework. Results were extracted to a synthesis table. The quality appraisal was conducted using JBI and CASP checklist.ResultsEight studies met the inclusion criteria. These included six randomised controlled trials, one quasi‐experimental study and one qualitative descriptive study. The current review identified various non‐pharmacological interventions for pain management in patients with dementia including singing, painting, massage, ear acupressure, play activities program and robot. The most common intervention was massage while the most effective intervention was play activities program. All studies provided evidence that non‐pharmacological interventions have an effect on pain management in patients with dementia or that there was a tendency for non‐pharmacological intervention to reduce pain in patients with dementia. Overall, the quality of the included studies was interpreted as strong (n = 8).ConclusionsOverall, interactive pharmacological interventions were more effective than non‐interactive non‐pharmacological interventions. While this review highlighted a limited number of studies investigating the use of non‐pharmacological interventions to manage pain in patients with dementia, it did however uncover a range of non‐pharmacological interventions used to manage pain in these patients along with their level of effectiveness.Relevance to clinical practiceFurther research is required to explore which non‐pharmacological interventions are most effective in the management of pain in patients with varying degrees of cognitive impairment. Further qualitative research is also needed to explore nurses' views on the use of non‐pharmacological interventions to manage pain in patients with dementia.
Maternal serum calprotectin level in intrahepatic cholestasis of pregnancy
Authors: Agaoglu Recep Taha , Celik Ozge Yucel , Yakut Kadriye , Celen Sevki , Caglar Ali Turhan 
Published: July 2021

AbstractAimThis study aimed to investigate maternal serum levels of calprotectin in patients with intrahepatic cholestasis of pregnancy (ICP) and to compare these with serum calprotectin levels in healthy pregnant women.MethodsNinety pregnant women (ICP group, n = 45; healthy control group, n = 45) were included in the study. The gestational age and body mass index of the participants in the two groups were similar. This prospective cross‐sectional study was conducted between November 2019 and May 2020 in the perinatology department of University of Health Sciences Doctor Zekai Tahir Burak Women's Education Hospital, Ankara, Turkey. Patients were recruited from those attending the perinatology outpatient and inpatient clinics. Biochemical (alanine aminotransferase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH), total bilirubin), fasting bile acid, hemogram, and calprotectin parameters of maternal blood were evaluated.ResultsThe mean fasting bile acid value in the ICP group was 30.3 ± 27.3 μmol, with severe ICP present in 11 (24.4%) patients. ALT, AST, LDH, total bilirubin, and mean platelet volume (MPV) values in the ICP group were higher and the red cell distribution width (RDW) value was lower than those in the control group (p < 0.001). The mean serum calprotectin levels in the control group and ICP group were 48.0 ± 10.4 and 765.4 ± 126.8 μg, respectively (p < 0.001). There was no significant correlation between serum fasting bile acid levels and serum calprotectin levels in the ICP group (p > 0.005).ConclusionSerum levels of calprotectin in patients with ICP were higher than those in healthy pregnant women. The serum calprotectin level may be an important diagnostic marker of ICP.
Maternal deaths due to COVID‐19 disease: The cases in a single center pandemic hospital in the south east of Turkey
Authors: Bağlı İhsan , Öcal Ece , Yavuz Mustafa , Uzundere Osman , Bozkurt Fatma 
Published: July 2021

AbstractCoronavirus‐19 disease is still a pandemic health problem and uncertainty in the management of severe or critically ill pregnant women confuses continually the obstetricians. The nationwide maternal mortality rate due to covid‐19 still has not been presented in any study in Turkey. The study includes four maternal mortality cases in a referral single pandemic center in our country. Case 1, a 34‐year‐old, 34 weeks of gestation with moderate disease. The cesarean section was performed due to nonreassuring nonstress tests. She died on the postpartum seventh day. Case 2, a 37‐year‐old, at 36 weeks of gestation. The symptoms consisted of dry cough, shortness of breath and labor pain, and 3 cm cervical opening. Her second cesarean section was performed and she died at postpartum ninth day. Case 3, 33 years old, 33 weeks of gestation with moderate/severe stage of the disease. A few days after the treatment, CS was performed due to her severe condition and she died at postpartum 15th day. Case 4, 39 years old, 35 weeks of gestation, she was at a severe stage of the disease. On the second day after the treatment, CS was performed due to her severe condition and she died at postpartum seventh day. The postpartum period after cesarean section should be followed cautiously under the appropriate treatment of the COVID‐19 disease. Unfortunately, the reason for this rapid deterioration which we observed in our cases is not well known and appropriate medications and algorithms should be established as soon as possible.
Quantitative sensory testing of mandibular somatosensory function following orthognathic surgery—A pilot study in Chinese with class III malocclusion
Authors: He Jiayi , Chen Xin , Yuan Hua , Zhang Ping , Jiang Hongbing , Wang Kelun , Svensson Peter 
Published: July 2021

AbstractBackgroundSomatosensory changes after sagittal split ramus osteotomy (SSRO) have not been fully studied in Chinese patients by the latest technologies.ObjectiveTo provide a comprehensive analysis of somatosensory function at the lower lip and chin at different time points following SSRO in a Chinese population.MethodsA total of 22 patients (18–27 years; nine men) with skeletal III malocclusion and scheduled for SSRO were recruited. Quantitative sensory testing (QST) was performed at pre‐operation (baseline), 1 week (1W), 1, 3 and 6 months (1M, 3M, 6M) post‐operatively. Cold detection threshold (CDT), warm detection threshold (WDT), cold pain threshold (CPT), heat pain threshold (HPT), mechanical detection threshold (MDT), mechanical pain threshold (MPT), pressure pain threshold (PPT) and two‐point discrimination threshold (2PD) were tested at the lower lip and chin.ResultsExcept for PPT at both test sides at 1W and 1M, all QST values indicated a significantly reduced sensitivity (p < .05). All values had returned to baseline values at 3M with exception of HPT at the right chin which, however, had recovered at 6M (p > .05).ConclusionsSomatosensory function at the lower lip and chin appears to be fully recovered in the majority of young Chinese adults 6 months after SSRO for skeletal class III malocclusion.
Portfolio diversification and model uncertainty: A robust dynamic mean‐variance approach
Authors: Pham Huyên , Wei Xiaoli , Zhou Chao 
Published: July 2021

AbstractThis paper focuses on a dynamic multi‐asset mean‐variance portfolio selection problem under model uncertainty. We develop a continuous time framework for taking into account ambiguity aversion about both expected return rates and correlation matrix of the assets, and for studying the join effects on portfolio diversification. The dynamic setting allows us to consider time varying ambiguity sets, which include the cases where the drift and correlation are estimated on a rolling window of historical data or when the investor takes into account learning on the ambiguity. In this context, we prove a general separation principle for the associated robust control problem, which allows us to reduce the determination of the optimal dynamic strategy to the parametric computation of the minimal risk premium function. Our results provide a justification for under‐diversification, as documented in empirical studies and in the static models. Furthermore, we explicitly quantify the degree of under‐diversification in terms of correlation bounds and Sharpe ratios proximities, and emphasize the different features induced by drift and correlation ambiguity. In particular, we show that an investor with a poor confidence in the expected return estimation does not hold any risky asset, and on the other hand, trades only one risky asset when the level of ambiguity on correlation matrix is large. We also provide a complete picture of the diversification for the optimal robust portfolio in the three‐asset case.
Interbank lending with benchmark rates: Pareto optima for a class of singular control games
Authors: Cont Rama , Guo Xin , Xu Renyuan 
Published: July 2021

AbstractWe analyze a class of stochastic differential games of singular control, motivated by the study of a dynamic model of interbank lending with benchmark rates. We describe Pareto optima for this game and show how they may be achieved through the intervention of a regulator, whose policy is a solution to a singular stochastic control problem. Pareto optima are characterized in terms of the solutions to a new class of Skorokhod problems with piecewise‐continuous free boundary. Pareto optimal policies are shown to correspond to the enforcement of endogenous bounds on interbank lending rates. Analytical comparison between Pareto optima and Nash equilibria provides insight into the impact of regulatory intervention on the stability of interbank rates.
Narrative diaries in the paediatric intensive care unit: A thematic analysis
Authors: Sansone Vincenza , Cancani Federica , Gagliardi Chiara , Satta Tiziana , Cecchetti Corrado , de Ranieri Cristiana , Di Nardo Matteo , Rossi Angela , Dall'Oglio Immacolata , Alvaro Rosaria , Tiozzo Emanuela , Gawronski Orsola 
Published: July 2021

AbstractBackgroundThe paediatric intensive care unit (PICU) diary is a shared tool, kept at the patient bedside, written by relatives and health care providers. There is little evidence about its feasibility and how it supports the families of children admitted to the PICU. Currently, there is no evidence about how the PICU diary is used and what we can learn from it.AimTo explore the contents of narrative PICU diaries in an Italian PICU.Study designQualitative study of PICU diaries conducted with a narrative research approach.MethodsChildren sedated and mechanically ventilated for >48 hours were enrolled in a six‐bed Italian PICU of a tertiary care paediatric hospital. During the child's PICU admission, caregivers, relatives, friends, and health care providers were invited to report events, thoughts, and messages, and attach drawings/pictures for the child in the PICU diary. A thematic analysis of the PICU diary contents was performed.ResultsThirteen PICU diaries were completed between August and December 2020, mainly by parents (n = 95; 45%) and health care providers (n = 52; 25%). Three main themes emerged: “Social and spiritual support,” “Caregiver's emotions, feelings and distress,” and “PICU life.” Diaries offer insight into caregivers' emotions, social support, clinical activities, and interactions with health care providers, and on progression towards recovery.ConclusionPICU diaries are valuable in facilitating family‐centred care by providing a space for the written account of the child's admission by parents, other visitors, and health care providers.Relevance to clinical practicePICU diaries support the relationship and the communication between the family and the team; they provide an informal account of the emotions and needs of parents that has the potential to improve mutual understanding and family‐centred care. Social support and spiritual support are key elements reported by parents for coping with their child's PICU admission.
Association analysis of SNPs in GRHL3, FAF1, and KCNJ2 with NSCPO sub‐phenotypes in Han Chinese
Authors: Sun Jia‐Lin , Shi Jia‐Yu , Yin Bin , Lin Yan‐Song , Shi Bing , Jia Zhong‐Lin 
Published: July 2021

AbstractObjectivesNon‐syndromic cleft palate only (NSCPO) is a common congenital deformity with complex etiologies. GRHL3, FAF1, and KCNJ2 have been reported to be involved in the pathogenesis of NSCPO. Up till now, there have been no replication studies based on large Han Chinese. Therefore, this study aimed to investigate associations between GRHL3, FAF1, KCNJ2, and NSCPO sub‐phenotypes patients in Han Chinese.Materials and MethodsFirstly, we selected 2 SNPs based on previous literatures: FAF1 (rs3827730) and GRHL3 (rs41268753). Also, we selected 8 tagSNPs in GRHL3 (rs557811, rs609352, rs10903078, rs6659209, rs12401714, rs12568599, rs3887581, rs12024148) and 2 tagSNPs in KCNJ2 (rs75855040 and rs236514). Afterward, we evaluated these SNPs among 1668 NSCPO patients and 1811 normal controls from Han Chinese. Following data were analyzed by PLINK and Haploview program.ResultsAssociation analysis under additive model showed that allele A at rs12568599 in GRHL3 gene is significantly associated with NSCPO (p = 0.0034, OR = 1.38 and 95%CI: 1.11–1.72) and its sub‐phenotype incomplete cleft palate (ICP) (p = 0.0039, OR = 1.4 and 95%CI: 1.11–1.75), and it could increase the risk of both NSCPO and ICP.ConclusionsThis study firstly found that rs12568599 in GRHL3 is associated with NSCPO and ICP in Han Chinese, indicating that sub‐phenotypes of NSCPO have different etiologies.
Target‐setting, political incentives, and the tricky trade‐off between economic development and environmental protection
Authors: Du Juan , Yi Hongtao 
Published: July 2021

AbstractDisentangling the relationship between economic development and environmental protection has attracted much attention from public administration scholars. While traditionally scholars approach the relationship from either a substitutive or a complementary perspective, we offer a nuanced perspective by examining how the target‐setting on economic growth shapes environmental performance. This article proposes an explanation for the impacts of gross domestic product growth targets on environmental performance based on a yardstick competition model, where the upper‐level governments use relative performance to create competition among lower‐level governments. We argue that a trade‐off exists between economic development and environmental performance; however, the substitutive relationship tends to transit to a complementary relationship when environmental performance is incorporated into the cadre evaluation system. Analyzing a panel dataset of economic targets and PM2.5 air pollution across Chinese cities from 2001 to 2010, we confirm the relationship between economic targets and environmental performance by highlighting local leaders' political incentives.
Applying the Pediatric Appendicitis Score to predict complicated appendicitis in children
Authors: Fujii Takayuki , Tanaka Aya , Katami Hiroto , Shimono Ryuichi 
Published: July 2021

AbstractBackgroundThis study aimed to investigate the efficacy of the Pediatric Appendicitis Score (PAS) and other indicators to enable the prediction of complicated appendicitis (CA) in children.MethodsThis retrospective cohort study evaluated children (n = 161) aged ≤16 years with acute appendicitis between 2008 and 2020. Demographic data, symptoms, physical findings, laboratory data, and PASs were collected. Multivariate analysis was performed to identify predictors for CA. Receiver operating characteristic (ROC) curves were constructed. The diagnostic performance of each predictor was evaluated.ResultsMultivariate analysis identified three predictors for CA: duration of symptoms >1 day, C‐reactive protein (CRP) level > 4 mg/dL, and PAS ≥ 8. The ROC curve of the combined three predictors showed an area under the curve of 0.91. The multivariate ROC curve revealed that the presence of a PAS contributed to a significant improvement in the diagnosis of CA compared to the absence of PAS. When combined, the three predictors had a high specificity of 99% and positive predictive value of 98%.ConclusionsA symptom duration >1 day, CRP > 4 mg/dL, and PAS ≥ 8 were predictors for CA. The PAS can be useful for prediction of CA when combined with the duration of symptoms, CRP, or both.
Expression of overadaptation in children through drawing a man as a projective measure: a community sample study
Authors: Horiuchi Fumie , Yoshino‐Ozaki Ayumi , Hattori Hideyuki , Hosokawa Rie , Nakachi Kiwamu , Ito Ruriko , Miyama Tomoe , Tachibana Yumina , Inoue Saori , Kawabe Kentaro , Ueno Shuichi 
Published: July 2021

AbstractBackgroundOveradaptation, the behavior of individuals who follow the expectations of others as perfectly as possible, is often observed and related to maladjustment, school refusal, and physical symptoms; however, no method has been proposed yet to assess the overadaptive tendency. This study evaluated the efficacy of the Goodenough Draw‐a‐Man (DAM) test as a projective measure of overadaptation in children.MethodsEighty children (36 boys, 44 girls), aged 6–8 years, were assessed for their ability to draw a man using the DAM test. Class teachers were asked to assess whether each child was overadapting. The total and subscale DAM scores and pass rates were compared between children with a teacher‐assessed tendency for overadaptation and control children, separately for girls and boys.ResultsThe mean total DAM score was significantly higher for girls versus boys for both the overadapting children and controls. For boys, no significant differences on the total and subscale DAM scores were noted between the overadapting boys and controls. Conversely, for girls, total and three subscale DAM scores (Mouth/Nose/Ears, Hair, Fingers) were significantly higher in the overadapting girls versus controls. Moreover, for girls, the DAM pass rates on five items (ratio of head; ears present; position and shape of nose; depiction of hair, not to see the scalp; details of fingers) were higher in the overadapting girls versus controls.ConclusionsThe DAM test could identify the overadaptive tendencies of girls aged 6–8 years.
First‐line haploidentical stem cell transplantation in children and adolescents with severe aplastic anemia using mobilized peripheral blood as source of CD34+: Single‐institutional experience in a transplant center from northeast Mexico
Authors: Gonzalez‐Villarreal Guadalupe , Pequeño‐Luevano Myrna , Baltazar‐Arellano Severiano , Sandoval Adriana , Sotomayor‐ Duque Guillermo , Martinez‐Pozos Gerardo , Ortega Andrés , de Leon Rosa , Hernandez Roberto 
Published: July 2021

AbstractIntroductionThe only curative treatment for severe aplastic anemia in children is an allogeneic stem cell transplant; however, few patients have a matched related or unrelated donor. Haploidentical stem cell transplantation (haplo‐SCT) using bone marrow (BM) and peripheral blood stem cells (PBSC) has been recently described as effective and safe. In this study, we retrospectively report the outcome of twelve pediatric patients who underwent haplo‐SCT using only PBSC.MethodsThe conditioning regimen consisted on rabbit anti‐thymocyte globulin (r‐ATG) 2.5 mg/kg/d on days −7, −6,‐5, and −4, and cyclophosphamide (Cy) 50 mg/kg/d on days −3 and −2. We used Cy 50 mg/kg/d on days +3 and +4, tacrolimus and mycophenolic acid as graft versus host disease (GVHD) prophylaxis.ResultsThe median follow‐up was 1,099 days (45–1258 days). The overall survival rate up‐to‐date is 83.3%. In 10 of the 12 patients, a sustained graft was achieved. None of the patients had acute or chronic GVHD.ConclusionsHaplo‐SCT could be established as a first‐line treatment when there is no matched related or unrelated donor. According to this short sample and previous reports, PBSC are a feasible option effectively used as the sole source of stem cells. Additionally, post‐transplant cyclophosphamide remains a good strategy for GVHD prevention.