bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-speed laser speckle imaging to unravel picoliter drop-on-demand to substrate interaction
Authors: Antonelli R. , Fokkink R. , Tomozeiu N. , Sprakel J. , Kodger T. E. 
Published: August 2021

Understanding phenomena such as evaporation and imbibition of picoliter droplets into porous substrates is crucial in printing industry to achieve a higher printing quality and print speed. After printing, the residual pigment must remain fixed at the desired location on a substrate and be of a desired volume to yield a high resolution and vibrantly printed page that has become the expectation of modern printing technology. Current research entails not only chemical composition of the ink but also how this links to the dynamics and interactions that occur between the ink and the substrate at every stage of the printed spot formation, including evaporation, wetting, and imbibition. In this paper, we present an instrument that can print on-demand picoliter volume droplets of ink onto substrates and then immediately record on evolution of the resulting dynamics when these two materials interact. This high-speed laser speckle imaging (HS-LSI) technique has been developed to monitor nanometer displacement of the drying and imbibing ink droplet at a high frame rate, up to 20000 Hz, given the short timescales of these interactions. We present the design of the instrument, discuss the related challenges and the theory underlying the LSI technique, specifically how photons non-evasively probe opaque objects in a multiple scattering regime, and show how this technique can unravel the dynamics of drying and imbibition. We will finish giving a validation on the instrument and an example of its usage.
Control of low flow regions in the cortical vasculature determines optimal arterio-venous ratios
Authors: Qi Yujia , Roper Marcus 
Published: August 2021

SignificanceLacking any ability to store glucose, the mammalian brain relies on a constant glucose and oxygen supply via the cerebral vasculature. In the cortex, this supply is maintained by parallel arterioles and venules. Yet, mathematical modeling of both real and idealized cortical networks shows that, far from being perfused uniformly, the cortex is strewn with regions of very low flow. Increasing the number of perfusing vessels increases the number of low-flow spots. Minimizing the influence of low-flow spots sets an optimal arteriole–venule ratio that we find to be closely recapitulated in data from real mammalian cortices. Further, low-flow regions complicate the regulation of metabolite delivery with neuronal activity, leading to unintuitive changes in perfusion when penetrating vessels dilate.
An outer-pore gate modulates the pharmacology of the TMEM16A channel
Authors: Dinsdale Ria L. , Pipatpolkai Tanadet , Agostinelli Emilio , Russell Angela J. , Stansfeld Phillip J. , Tammaro Paolo 
Published: August 2021

Significance
The TMEM16A calcium-gated chloride channels participate in a range of vital physiological functions. TMEM16A channels are desirable new drug targets as their dysfunction can lead to pathology. In spite of this, their pharmacology is still in its infancy. Gaining insight into the mode of action and binding sites for test compounds forms the basis for the development of new TMEM16A-interacting drugs. Here, we demonstrate that intracellular calcium triggers a conformational change in the outer mouth of the channel, which enables entry of a small molecule into the pore. Characterization of this structural rearrangement defines a critical site for pharmacological intervention and reveals an aspect of calcium gating in the TMEM16A channel.
Genealogical structure changes as range expansions transition from pushed to pulled
Authors: Birzu Gabriel , Hallatschek Oskar , Korolev Kirill S. 
Published: August 2021

Significance
Spatial dynamics are important for understanding genetic diversity in many contexts, such as cancer and infectious diseases. Coalescent theory offers a powerful framework for interpreting and predicting patterns of genetic diversity in populations, but incorporating spatial structure into the theory has proven difficult. Here, we address this long-standing problem by studying the coalescent in a spatially expanding population. We find the topology of the coalescent depends on the growth dynamics at the front, but not on the functional form of the growth function. Instead, the transition between coalescent topologies is determined by a single dynamical parameter. Our theory makes precise predictions about the effects of population dynamics on genetic diversity at the expansion front, which we confirm in simulations.
Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19
Authors: Mirabelli Carmen , Wotring Jesse W. , Zhang Charles J. , McCarty Sean M. , Fursmidt Reid , Pretto Carla D. , Qiao Yuanyuan , Zhang Yuping , Frum Tristan , Kadambi Namrata S. , Amin Anya T. , O’Meara Teresa R. , Spence Jason R. , Huang Jessie , Alysandratos Konstantinos D. , Kotton Darrell N. , Handelman Samuel K. , Wobus Christiane E. , Weatherwax Kevin J. , Mashour George A. , O’Meara Matthew J. , Chinnaiyan Arul M. , Sexton Jonathan Z. 
Published: August 2021

Significance
Since its emergence in China in December 2019, SARS-CoV-2 has caused a global pandemic. Repurposing of FDA-approved drugs is a promising strategy for identifying rapidly deployable treatments for COVID-19. Herein, we developed a pipeline for quantitative, high-throughput, image-based screening of SARS-CoV-2 infection in human cells that led to the identification of several FDA-approved drugs and clinical candidates with in vitro antiviral activity.
Bacterial translation machinery for deliberate mistranslation of the genetic code
Authors: Vargas-Rodriguez Oscar , Badran Ahmed H. , Hoffman Kyle S. , Chen Manyun , Crnković Ana , Ding Yousong , Krieger Jonathan R. , Westhof Eric , Söll Dieter , Melnikov Sergey 
Published: August 2021

Significance
Aminoacyl-transfer RNA (tRNA) synthetases (aaRSs) are essential enzymes that mediate accurate expression of the genetic code. More than 96% of analyzed species possess duplicated aaRSs genes, which are presumed to encode canonical aaRSs. However, in this study, we show that some of these seemingly canonical aaRSs are in fact repurposed for deliberate mistranslation of the genetic code, enabling organisms to encode two amino acids using a single sense codon. This finding, along with the abundance of duplicated aaRSs genes, suggests that the deliberate mistranslation of sense codons may be more common than previously thought. More broadly, our work illustrates that extant genomes have many exciting functionalities that are currently hidden under a disguise of canonical tRNA synthetases and tRNAs.
Interdental /s/ in Salvadoran Spanish
Authors: Iraheta Ana Cecilia 
Published: August 2021

Abstract
This study provides a systematic account of the occurrence of interdental /s/ in Salvadoran Spanish and explores
speakers’ attitudes toward its use.
Specifically, it examines the linguistic, social, and stylistic contexts in which this understudied variant
occurs, and it describes how the speakers construct meaning through it despite being a stigmatized variant. It was found that this
variant is more likely to be observed in syllable-onset position both word-medially and initially. Additionally, it is more likely
to be observed in casual style in the youngest and oldest age groups and it is less likely observed in the speech of
professionals. There are indications that this variant is associated with an age-grading phenomena, which is also indicative of
stable variation. The present work fills an almost a 30+ year old gap left by previous studies that only briefly touched upon this
variant.
Recovering the potential and order in one-dimensional time-fractional diffusion with unknown initial condition and source
*
Authors: Jin Bangti , Zhou Zhi 
Published: August 2021

Abstract
This paper is concerned with an inverse problem of recovering a potential term and fractional order in a one-dimensional subdiffusion problem, which involves a Djrbashian–Caputo fractional derivative of order α ∈ (0, 1) in time, from the lateral Cauchy data. In the model, we do not assume a full knowledge of the initial data and the source term, since they might be unavailable in some practical applications. We prove the unique recovery of the spatially-dependent potential coefficient and the order α of the derivation simultaneously from the measured trace data at one end point, when the model is equipped with a boundary excitation with a compact support away from t = 0. One of the initial data and the source can also be uniquely determined, provided that the other is known. The analysis employs a representation of the solution and the time analyticity of the associated function. Further, we discuss a two-stage procedure, directly inspired by the analysis, for the numerical identification of the order and potential coefficient, and illustrate the feasibility of the recovery with several numerical experiments.
Experimental overview on pairing mechanisms of BiCh2-based (Ch: S, Se) layered superconductors
Authors: Hoshi Kazuhisa , Mizuguchi Yoshikazu 
Published: August 2021

Abstract
BiCh2-based (Ch: S, Se) layered superconductors have attracted extensive attentions because of variation of materials and physical characteristics, which include relatively large spin–orbit coupling originating from bismuth 6p orbitals, and the possibility of anisotropic superconducting gap. Some of theoretical studies suggested that anisotropic superconductivity is realized in the BiCh2-based superconductors. In experimental studies, angle-resolved photoemission spectroscopy measurement on the superconducting states of Nd(O,F)BiS2 have revealed the anisotropic structure of the superconducting gap, and the absence of isotope effect have been reported, indicating unconventional superconductivity pairing. Furthermore, two-fold-symmetric in-plane anisotropy of magnetoresistance have been observed in the superconducting states of some of Bi(S,Se)2-based systems like La(O,F)Bi(S,Se)2 while the crystal structure possesses a tetragonal square plane with four-fold symmetry. Those results indicate nematic superconductivity is emerging in BiCh2-based superconductors. On the basis of the observations suggesting unconventional superconductivity in BiCh2-based systems, clarification of pairing mechanisms of superconductivity in BiCh2-based superconductors have been highly desired. In this article, we review experimental results on the superconducting gap structure, the pairing mechanism, and related phenomena of BiCh2-based superconductors.
The Influence of the Building Mass Configuration of Settlements around the UNNES Campus on Environmental Carrying Capacity
Authors: Prihanto T , Purwanto E , Pandelaki E E 
Published: August 2021

Abstract
The impact of the development of the UNNES Campus in Sekaran, a suburb of Semarang City, has become a trigger for the growth of new activities which require the provision of new spaces, especially settlements. This phenomenon shows the growth of settlements that ignore the environment. This study aims to examine the influence of the building mass configuration of settlements around the UNNES Sekaran Campus on environmental carrying capacity as a buffer zone for Semarang City. This studi uses descriptive exploratory method which aims to describe the state of a phenomenon in the field. The results of this study are the influence of the building mass configuration of settelements on environmental carrying capacity. The configuration of the building mass that does not pay attention to rainwater infiltration and reduction of sun exposure has an impact on reducing the supporting capacity of the environment and reducing occupant comfort.
The Effect of Reinforcement of Bamboo Matting, Bamboo Grids, and Geotextiles on Non-Woven Increasing the Carrying Capacity of Clay Soil Using the Loading Test
Authors: Pinka H F , Wibowo D E , Endaryanta  , Munawir R 
Published: August 2021

Abstract
Nowadays, various soil improvement methods have been developed. One of them is the soil reinforcement method as an alternative solution to subsidence and low soil bearing capacity. This study aimed to determine the effect of reinforcing bamboo mats, bamboo grids, and geotextiles non-woven on increasing the bearing capacity of clay soil and comparing the bearing capacity of each variation with the value of the bearing capacity without reinforcement. This research is an experimental study using the loading method with the modeling of the underburdened soil conditions. This study uses woven bamboo reinforcement, bamboo grids, and geotextiles non-woven. Each effect of the reinforcing material on the clay is sought for the ultimate bearing capacity value. The results showed that: (1) the type of soil according to the USCS classification in Kalangan Hamlet, Bangunjiwo Village, Kasihan District, Bantul Regency, Yogyakarta Special Region is inorganic clay with high plasticity, fat clays with code CH (high clay plasticity). According to AASHTO, the soil classified in group A-7-6 (40), (2) the addition of reinforcing bamboo mats, grids bamboo, and geotextiles non-woven can increase the ultimate bearing strength (3) strengthening the bamboo grid can provide an increase in value. The ultimate bearing strength (qult), which is dominant, is 3.4 times that of the original soil without reinforcement with a bearing capacity ratio (BCR) of 3.44 or a 234.43% increase in percentage. This study shows that bamboo is more effective in transferring and spreading loads to the soil.
Strengthening of Non-Engineered Building with Steel Plate to Increase Seismic Performance
Authors: Purwanto E , Kristiawan S A , Sangadji S , Saifullah H A 
Published: August 2021

Abstract
Residential buildings are included in the category of non-engineered buildings that suffered the most damage during an earthquake. This is because most of the building materials used and the working techniques, especially the reinforcement, do not meet the requirements. This research will be reviewed numerically using ATENA software on three types of numerical models, each of which represents non-engineered buildings, engineered buildings and reinforcement models with steel plates. The results showed that the non-engineered building model would experience the largest deflection and the smallest load bearing capacity, while the other 2 models experienced a smaller displacement with a greater load capacity. The best performance is shown in models with steel plate reinforcement, so that the reinforcement of steel plates in non-technical buildings will effectively increase the performance of non-engineered buildings.
Initial Study of Arterial Road Traffic and Socio-Economic Characteristics in Malang Regency
Authors: Susilowati  , Susanti Aria Indah , Nugroho Meriana Wahyu 
Published: August 2021

Abstract
Malang Regency is an area with the second busiest road traffic after Surabaya. The purpose of this study is to determine the characteristics of the movement of speed and volume of traffic and performance on arterial roads in Malang Regency. The data collection technique used literature study, conducted a survey at each location point of the research area with the Annual Average Daily Traffic (AADT). The analysis technique used the Highway Capacity Manual Indonesia (MKJI) 2017. The results showed that the level of road service with category B was in Wonosari District with a saturation degree of 0.372, the level of road service category C was in Wagir, Gedangan, Ngajum and Tirtoyudo Districts with saturation degrees between 0.565-0.678 and the level of road service category D in Wajak District with degree of saturation 0.798. Meanwhile, 27 roads have a poor service level which is included in the E and F categories with the degree of saturation > 0.850. Recommend policies regarding restrictions on the use of private vehicles and alternative traffic engineering to divert transportation routes to new land uses and to more intensively disseminate information to the public on using public transportation as a means of daily transportation.
Marshall Characteristic Of Asphalt Concrete Wearing Course Using Crude Palm Oil and Pen 60/70 As A Binder
Authors: Chaira  , Refiyanni M , Azwanda  
Published: August 2021

Abstract
Asphalt is one of the non-renewable natural resources. It is necessary to conduct various studies regarding alternative materials can be used as a substitute for asphalt. Crude palm oil (CPO) has almost the same texture and properties as asphalt, when it is heated it will melt so it can be substituted as a binding agent in the AC-WC layer. Based on the background, this study aims to analyze the effect of 50% CPO substitution and 50% pen 60/70 on the AC-WC layer. This research is based on the Public Works Department General specifications in 2010 using the marshall method by varying 50% CPO and 50% pen 60/70. Variation of 50% CPO and 50% 60/70 pen get Asphalt Optimum Content (AOC) value of 4.5% from the test results of 15 test specimens and 6 specimens using AOC. The results of the test with a 30-minute immersion (stability) all the characteristics meet the marshall parameters that are implied, namely: a stability value of 842 kg, a Flow of 3.1 mm, a VIM of 4.64%, a VMA of 15.30%, a VFB of 69, 67% and the MQ value of 271.51 kg / mm. Marshall testing with a 24-hour immersion (durability) did not meet the specifications required so that this pavement is not durable.
Perception of Pedestrian to Pedestrian Lane Conditions in Yogyakarta (Case Study: Gejayan Street, Sleman)
Authors: Luthfi M B , Hidayah R 
Published: August 2021

Abstract
Streets and sidewalks are inseparable for users. Users especially pedestrians use the sidewalk as access to move from one to another place. The existence of the sidewalk increases the ease in each person to continue to move in a place that is not too far apart so that it is more efficient and effective. Sidewalks with accessibility and environmental quality that support will make the community in an area. This research is a survey research using a questionnaire. Respondents were randomly selected as many as 100 people around Gejayan street sidewalk. The pedestrian classification is divided based on stationary pedestrians and mobiler pedestrians. Stationary pedestrians are pedestrians who carry out their daily activities around the sidewalk path. Whereas a mobile pedestrian is a pedestrian who uses the sidewalk pathway only as a path to move between places at certain times. The results showed the level of comfort of stationary pedestrians on Gejayan street was 55.74% and the level of comfort of mobile pedestrians on Gejayan street was 55.77%. So that it is obtained if the comfort level of both types of pedestrians are categorized as quite comfortable.
Android-Based Public Transport Violation Reporting Application
Authors: Yulianto Budi , Setiono  
Published: August 2021

Abstract
The rise of violations of traffic regulations and standard operating procedures for Batik Solo Trans public transport by public transport drivers is caused by weak law enforcement with limitations of law enforcement officials in its implementation. In this regard, a tool is needed to support law enforcement, particularly in relation to the violation reporting system of the traffic and standard operating procedures for Batik Solo Trans public transport. The reporting tool must be effective, efficient and transparent in its reporting system. The aim of the study is to develop an Android-based public transport violation reporting application called BST Watch App. Android is a Linux-based operating system designed for touch screen mobile devices such as smartphones and tablet computers. Android is an operating system with open source and Google releases the code under the Apache License. The application system is created by using the java programming language. The results of public transport violations characteristic analysis in the study area indicate that the type of violation which is often occurs is picking up and dropping off passengers at outside the bus stop. The implementation of the BST Watch App shows that this application is easy to use, practical, accurate, and transparent.
Development of Sustainable Infrastructure in Eastern Indonesia
Authors: Wibawa Bakti , Fauzi Ibnu , Novianti Dian A , Shabrina Nurul , Saputra Andika D , Latief Syahrizal A 
Published: August 2021

Abstract
The condition of limited infrastructure in Indonesia positions that current infrastructure is very important to be built immediately to support development in various fields so that economic, trade, industrial and other social activities run more smoothly and develop, so that the dynamics of society in all corners of the country will increase. The cost of producing electricity in Eastern Indonesia, such as Sulawesi, Papua, Maluku and Nusa Tenggara is currently 2 to 5 times the cost of producing electricity in Java, Bali and Sumatra. One of the ways that should be intensified is by building a small-scale Liquid Natural Gas (LNG) infrastructure concept that aims to meet the needs of gas consumers who do not receive gas pipelines or who require small volumes of gas, for example small capacity power plants, especially those in islands in Eastern Indonesia. In this archipelago, it is impossible for all regions to be connected by pipelines that cross the oceans, because of course it requires very large funds. The application of small-scale LNG technology is the right solution for LNG supply in Eastern Indonesia. If the energy infrastructure is available, the quality of human resources must also be improved so that they become human resources who are always active and always adapt to developments.
Application of TRMM in Deriving Intensity-Duration-Frequency Curve in Bandung Area
Authors: Sanjaya S , Yudianto D 
Published: August 2021

Abstract
A rainfall Intensity-Duration-Frequency curve serves vital purposes in urban water management, typically generated using a long historical rainfall record. In most cases, such measurement is often sparse or poorly done. Hence it becomes a significant challenge to derive this curve. However, many studies have demonstrated the use of satellite rainfall measurement to cope with this data shortage. One of them is TRMM 3B42 Daily, which is employed in this study. This paper presents the application of TRMM to derive a better IDF curve in a data-scarce region for urban water management. It takes place in Bandung, where most of the upstream catchment area has limited rainfall records. The result shows that the TRMM-derived IDF curve demonstrates underestimated rainfall intensity compared to the ground measurement one. Consequently, the correction of daily data TRMM is necessary to improve the performance of TRMM-derived IDF. The correction of daily TRMM has statistically improved the performance of IDF. It is exhibited by the decreasing value of RMSE and RE. This analysis was culminated by producing an updated IDF curve using TRMM data from 1998-2019 for Bandung City. There is no significant trend that appears in rainfall intensity from 2016-2019.