bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Characteristics and Preferences Regarding Anticoagulant Treatment in Venous Thromboembolic Disease
Authors: Lanéelle Damien , Le Brun Charles , Mauger Chadi , Guillaumat Jérôme , Le Pabic Estelle , Omarjee Loukman , Mahé Guillaume ,   SFMV VTE Study Group
Published: June 2021

Background: Anticoagulants are the recommended treatment for venous thromboembolic disease (VTE). The mode of anticoagulant administration may influence compliance, and therefore the effectiveness of the treatment. Unlike in atrial fibrillation or cancer-associated thrombosis, there is only limited data on patient preferences regarding the choice of anticoagulation in VTE. This study aims to evaluate patient preferences regarding anticoagulants in terms of administration: types (oral or injectable treatment) and number of doses or injections per day.Patients and Methods: This is a national survey through a questionnaire sent by e-mail to 1936 French vascular physicians between February and April 2019. They recorded the responses for each patient admitted for VTE.Results: Three hundred and eleven (response rate of 16%) of the 1936 contacted physicians responded for 364 patients. Among these, there were 167 fully completed questionnaires. Most patients (63%) express concerns about VTE and prefer oral treatment (81.5%), justified by the ease of administration (74%) and a fear of the injections (22%). When patients were taking more than three oral treatments they statistically chose injectable treatment more often (54%) than oral treatment (25%, p = 0.002). Patients who chose injectable treatment were also older (70 ± 16 vs. 58 ± 17 years old, p = 0.001). There was no statistically difference in anticoagulation preference according to gender or to the expected duration of treatment (6 weeks, 3 months, 6 months or unlimited). When oral treatment was preferred (81%), most chose oral treatment without dose adjustment and biomonitoring (74.3%). Among them, very few (5.8%) preferred a twice-daily intake.Conclusion: Patient preference in terms of anticoagulant treatment in VTE disease is in favor of oral treatment without adjustment or biomonitoring and with once-daily intake. When an injectable treatment is chosen, a prolonged duration of treatment does not seem to be a constraint for the patient.Clinical Trial Registration:ClinicalTrials.gov, identifier [NCT03889457].
Dual Antiplatelet Therapy vs. Single Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: An Updated Systematic Review and Meta-Analysis
Authors: Zhang Yipeng , Shen Lan , Yang Wentao , He Ben 
Published: June 2021

Background: Although mainstream guidelines recommend dual antiplatelet therapy (DAPT) with aspirin and clopidogrel in patients following transcatheter aortic valve replacement (TAVR), it is not evidence-based. We aim to investigate the safety and efficacy of DAPT vs. single antiplatelet therapy (SAPT) after TAVR, and review updated evidence.Methods: We systematically searched PubMed, Embase, and Cochrane for studies comparing DAPT to SAPT after TAVR from inception to November 30, 2020. The primary outcome was major adverse cardiac and cerebrovascular events, including all-cause mortality, cardiovascular death, myocardial infarction (MI), stroke, and major or life-threatening bleeding (LTB). Subgroup analysis was performed according to study type (randomized control trials vs. observational studies) using a fixed-effects model. The quality of evidence was assessed by two scoring systems and GRADE (Grading of Recommendations Assessment, Development, and Evaluation).Results: Twelve studies of 20,766 patients were included in our meta-analysis. Compared with SAPT, DAPT was associated with an increased risk for combined life threatening and major bleeding [OR 1.73 (1.19–2.51), p = 0.004] after TAVR. Such a difference was largely driven by major bleeding [OR 2.29 (1.68–3.11), p &lt; 0.001]. There were no significant differences on major adverse cardiovascular events (MACE) [OR 1.19 (0.99–1.44), p = 0.07], cardiovascular mortality [OR 1.46 (0.93–2.30), p = 0.10], and stroke [OR 0.97 (0.80–1.16), p = 0.71].Conclusions: Compared with SAPT, post-TAVR DAPT was associated with increased risks of major or life-threatening bleeding without additional benefits of reducing thrombotic events. Future guidelines for post-TAVR antiplatelet strategy are expected to be updated as new high-quality evidence emerges.Systematic Review Registration: PROSPERO, Identifier: CRD42021230075.
Anticoagulation Therapy After Biologic Aortic Valve Replacement
Authors: Myllykangas Monna E. , Kiviniemi Tuomas O. , Gunn Jarmo M. , Salomaa Veikko V. , Pietilä Arto , Niiranen Teemu J. , Aittokallio Jenni 
Published: June 2021

Objectives: Thromboembolism prophylaxis after biologic aortic valve replacement (BAVR) is recommended for 3 months postoperatively. We examined the continuation of oral anticoagulation (OAC) treatment and its effect on the long-term prognosis after BAVR.Methods: We used nation-wide register data from 4,079 individuals who underwent BAVR. We examined the association between warfarin and the non-vitamin K antagonist oral anticoagulant use with death, stroke and major bleeding in 2010 – 2016.Results: The risk of stroke was higher (HR 2.39, 95% CI 1.62 – 3.53, p &lt; 0.001) and the risk of death was lower (HR 0.79, 95% CI 0.65 – 0.96, p = 0.016) in OAC-users compared to individuals without OAC. We observed no significant associations between OAC use and bleeding risk.Conclusion: OAC use after BAVR was associated with increased risk of stroke and decreased risk of death. These observational findings warrant validation in randomized controlled trials before any clinical conclusions can be drawn.
Renal Endometriosis Mimicking Cystic Renal Tumor: Case Report and Literature Review
Authors: Yang Ye , Zhao Xinxin , Huang Ying 
Published: June 2021

Background: Endometriosis mainly affects female pelvic tissues and organs, and the presence of endometriosis in the kidney is extremely rare.Case Presentation: We report a case of a 48-year-old woman who presented with intermittent hematuria. She was found to have a cystic mass on renal ultrasonography, and contrast-enhanced computed tomography (CT) showed slight enhancement of the cystic wall and septa. These findings were indicative of cystic renal tumor. The patient subsequently underwent partial right nephrectomy. Histopathology revealed endometriosis of the right renal parenchyma. The patient recovered well and had no evidence of a recurrent renal mass at the 3 months' follow up.Conclusion: The possibility of renal endometriosis should be considered in a female patient with a cystic renal mass and clinical symptoms related to the menstrual cycle.
A Comparative Study on the Psychological Health of Frontline Health Workers in Wuhan Under and After the Lockdown
Authors: Qiu Xiuli , Lan Yan , Miao Jinfeng , Wang Hui , Wang He , Wu Jianhong , Li Guo , Zhao Xin , Cao Ziqin , Mei Junhua , Sun Wenzhe , Zhu Zhou , Zhu Suiqiang , Wang Wei 
Published: June 2021

Background: The coronavirus disease-2019 (COVID-19) outbreak and a 3-month lockdown of Wuhan may have had a long-term impact on the mental health of frontline healthcare workers (HWs). However, there is still a lack of comparative studies on the mental health of front-line HWs in the initial phase of the lockdown and 1 month after the lifting of the lockdown.Methods: We recruited 1717 HWs during the initial phase of the lockdown and 2214 HWs 1 month after the lifting of the lockdown, and their baseline characteristics and psychiatric health in these two phases were compared. Furthermore, Pearson's Chi-square test and multivariate logistic regression analysis were used to determine the possible risk factors associated with depressive symptoms in the front-line HWs.Results: Compared with the initial phase of the lockdown, the proportion of HWs with anxiety symptoms and stress decreased, while the proportion of HWs with depressive symptoms increased a month after the lifting of the lockdown. Male sex, exercise habit, comorbidities, and having family members or relatives with suspected or confirmed COVID-19 infection were significantly related to the increased incidence of depressive symptoms during the initial phase of the lockdown. Comorbidities, negative effect of media coverage, working &gt;4 days a week, lower annual household income, and deteriorating relationships with family members were associated with depressive symptoms a month after the lifting of the lockdown.Conclusion: The increased proportion of HWs with depressive symptoms 1 month after the lifting of the lockdown suggested that mental health of front-line HWs should be a top-priority issue, not only during, but also after the pandemic.
Comparison of Two Malnutrition Assessment Scales in Predicting Postoperative Complications in Elderly Patients Undergoing Noncardiac Surgery
Authors: Zhang Fang , He Shu-Ting , Zhang Yan , Mu Dong-Liang , Wang Dong-Xin 
Published: June 2021

Background: The present study was designed to investigate the relationship between two malnutrition assessment scales, perioperative nutrition screen (PONS) and Nutritional Risk Screening 2002 (NRS2002), with postoperative complications in elderly patients after noncardiac surgery.Methods: This was a secondary analysis of a prospective cohort study. Elderly patients (65–90 years) undergoing noncardiac surgery were enrolled in Peking University First Hospital. Malnutrition was screened by PONS and NRS2002 at the day before surgery. Multivariable analysis was employed to analyze the relationship between PONS and NRS2002 and postoperative 30-day complications. Receiver operating characteristic (ROC) curve was generated to evaluate the predictive value of PONS and NRS2002 in predicting postoperative complications.Results: A total of 915 patients with mean age of 71.6 ± 5.2 years were consecutively enrolled from September 21, 2017, to April 10, 2019. The incidence of malnutrition was 27.3% (250/915) by PONS ≥ 1 and 53.6% (490/915) by NRS2002 ≥ 3. The overall incidence of complications within postoperative 30 days was 45.8% (419/915). After confounders were adjusted, malnutrition by PONS ≥ 1 (OR 2.308, 95% CI 1.676–3.178, P &lt; 0.001), but not NRS2002 ≥ 3 (OR 1.313, 95% CI 0.973–1.771, P = 0.075), was related with an increased risk of postoperative complications. ROC curve analysis showed that the performances of PONS [area under the ROC curve (AUC) 0.595, 95% CI 0.558–0.633] showed very weak improvement in predicting postoperative complications than NRS2002 score (AUC 0.577, 95% CI 0.540–0.614).Conclusion: The present study found that malnutrition diagnosed by PONS was related with an increased risk of postoperative complications. The performances of PONS and NRS2002 were poor in predicting overall postoperative complications.Clinical Trial Registration:www.chictr.org.cn, identifier: ChiCTR-OOC-17012734.
Visualization of Endolymphatic Hydrops in Patients With Unilateral Idiopathic Sudden Sensorineural Hearing Loss With Four Types According to Chinese Criterion
Authors: Qin Huan , He Baihui , Wu Hui , Li Yue , Chen Jianyong , Wang Wei , Zhang Fan , Duan Maoli , Yang Jun 
Published: June 2021

Objective: The aim of this study is to evaluate the possible value of endolymphatic hydrops (EH) in patients with unilateral idiopathic sudden sensorineural hearing loss (UISSNHL) with four types according to audiometry.Methods: Seventy-two patients (40 men and 32 women; age range, 28–78 years; mean age: 50.0 ± 12.9 years) with UISSNHL were admitted retrospectively into this study. Based on the pure tone audiometry before treatment, the hearing loss of all these patients were categorized into four types: low-frequency group (LF-G), high-frequency group (HF-G), flat group (F-G), and total deafness group (TD-G). The average time from symptom onset to the first examination was 6.9 ± 4.4 days (1–20 days). 3D-FLAIR MRI was performed 24 h after intratympanic injection of gadolinium (Gd) within 1 week after the UISSNHL onset. The incidence of EH in the affected ears based on four types of hearing loss were analyzed using the Chi-square test, and the possible relationship with vertigo and prognosis were also assessed.Results: Eleven of 21 patients (52.4%) in LF-G had the highest EH-positive rate, followed by 18.2% in HF-G, 11.8% in F-G, and 17.4% in TD-G. The significant difference was found in the four groups (P = 0.018). The EH rate of LF-G was statistically significantly higher than that of F-G and TD-G (P = 0.009, P =0.014), respectively. After being valued by the volume-referencing grading system (VR scores), the EH level was represented by the sum scores of EH. In LF-G, no statistically significant difference was found in the prognosis of ISSNHL patients between with the EH group and the no EH group (P = 0.586). The symptom “vertigo” did not correlate with EH and prognosis.Conclusions: EH was observed in UISSNHL patients by 3D-FLAIR MRI. EH may be responsible for the pathology of LF-G but not related to prognosis. It might be meaningless to assess EH in other hearing loss types, which might be more related to the blood-labyrinth dysfunction.
Active-Sensing Epidermal Stretchable Bioelectronic Patch for Noninvasive, Conformal, and Wireless Tendon Monitoring
Authors: Shu Sheng , An Jie , Chen Pengfei , Liu Di , Wang Ziming , Li Chengyu , Zhang Shuangzhe , Liu Yuan , Luo Jianzhe , Zu Lulu , Tang Wei , Wang Zhong Lin 
Published: June 2021

Sensors capable of monitoring dynamic mechanics of tendons throughout a body in real time could bring systematic information about a human body’s physical condition, which is beneficial for avoiding muscle injury, checking hereditary muscle atrophy, and so on. However, the development of such sensors has been hindered by the requirement of superior portability, high resolution, and superb conformability. Here, we present a wearable and stretchable bioelectronic patch for detecting tendon activities. It is made up of a piezoelectric material, systematically optimized from architectures and mechanics, and exhibits a high resolution of

5.8
×

10

−
5

N

with a linearity parameter of

R

2

=
0.999

. Additionally, a tendon real-time monitoring and healthcare system is established by integrating the patch with a micro controller unit (MCU), which is able to process collected data and deliver feedback for exercise evaluation. Specifically, through the patch on the ankle, we measured the maximum force on the Achilles tendon during jumping which is about 16312 N, which is much higher than that during normal walking (3208 N) and running (5909 N). This work not only provides a strategy for facile monitoring of the variation of the tendon throughout the body but also throws light on the profound comprehension of human activities.
War Specials of Vallal Athiyaman Neduman Anji
Authors: C Malathi , M Sundaramoorthi 
Published: June 2021

Sangam Literature one of the ancient Tamil literature is a golden treasure to know tradition, culture and war specials of ancient Tamil people. One of the ancient well known tamil king was Vallal Athiyaman Neduman Anji, who ruled Thahadoor which is Dharmapuri now and know for his vallal and generosity. The present study aims to find out the uniqueness of Athiyaman’s war specials from the rest of the wars that happened during the contemporary time. The study explores how Vallal Athiyaman was patriotic, courageous, never bent his head or never been a slave, lived with dignity and self righteousness . He was a brave warrior and at the same time a kind hearted king who helped people with at most care and affection. The study includes the analysis of vallal Athiyaman’s appearance, nature of his soldiers, war with seven enemies, war of Kovalur, war of Thahadoor and the season for the war, It includes how the concept of war in the present scenario similar to the wars of the past with the motto of expanding the kingdom.
DEVELOPMENT OF FIRE-PROTECTIVE PLASTER SURFACES COMPOSITES AND DESIGN METHOD FOR DETERMINING THE FIRE RESISTANCE OF TWO-LAYER ARMOCEMENT ELEMENTS
Authors: Хежев Т.А. 
Published: June 2021

Приведены результаты исследований составов гипсоизвестковоцементовермикулитотуфобетонных композитов. Расширение сырьевой базы, повышение прочности и огнезащитных свойств, а также снижение стоимости композита решается за счет использования в сырьевой смеси отходов пиления вулканического туфа. Приведены результаты экспериментальных исследований огнестойкости двухслойных армоцементных элементов. Разработан алгоритм теплотехнического расчета предела огнестойкости многослойных строительных конструкций, обеспечивающий приемлемое совпадение расчетных значений с экспериментальными данными. Разработано программное обеспечение теплотехнического расчета предела огнестойкости армоцементных конструкций с огнезащитным слоем из гипсовермикулитобетона, получены выражения для коэффициентов теплопроводности и теплоемкости разработанных композитов.
The results of studies of gypsumlimestone cementvermiculite and concrete composites are given. Expanded resource base, increased strength and flame retardant properties, as well as reduced cost of the composite. using volcanic tuff in the raw mix. The results of experimental studies of the fire resistance of twolayer cementcontaining elements are given. An algorithm for heat engineering calculation of the fire resistance limit of multilayer building structures has been developed, which ensures acceptable agreement between the calculated values and experimental data. The software for the heat engineering calculation of the fire resistance limit of cementcement constructions with a fireproof layer made of gypsum vermiculite concrete has been developed, expressions for the thermal conductivity and heat capacity of the developed composites have been obtained.
PROFESSIONAL DEVELOPMENT IS THE BASIS OF PROFESSIONALISM OF A MODERN TEACHER
Authors: Усамов И.Р. , Usamov I.R. 
Published: June 2021

Профессиональное развитие это способ не только оставаться в курсе событий, но и включиться в различные социально-образовательные группы, проверить свои знания в связи с последними достижениями, спроецировать себя в качестве знающего эксперта перед своими студентами или слушателями и тем самым завоевать всеобщее доверие. Профессиональное развитие может даже продвинуть нас на более высокую позицию в существующей иерархии. В данной статье затрагивается проблема повышения профессионализма путем прохождения курсов повышения квалификации. Рассматриваются разные механизмы проведения курсов повышения квалификации. Определена важность повышения квалификации работника сферы образования, так как он делает будущее страны, передает частицу себя подрастающему поколению. Профессиональное развитие играет очень важную роль в нашей жизни, так как, развивая его, мы приобретаем больше уверенности в общении с другими людьми. В сфере образования это становится все более важным, так как взаимодействие является очень важной частью в обучении. Мы хорошие учителя, когда наше взаимодействие впечатляет и понятно.
Professional development is a way not only to stay up to date, but also to become involved in various social and educational groups, to test your knowledge in connection with the latest achievements, to project yourself as a knowledgeable expert in front of your students or listeners and thus gain universal trust. Professional development can even move us to a higher position in the existing hierarchy. This article deals with the problem of professional development through training courses. Different mechanisms of training courses are considered. The importance of professional development of the employee of the sphere of education is defined, as he makes the future of the country, transfers a part of himself to the younger generation. Professional development plays a very important role in our lives, as by developing it, we gain more confidence in communicating with other people. In education, this is becoming increasingly important as interaction is a very important part in learning. We are good teachers when our interaction is impressive and understandable.
Fermentasi Jerami sebagai Pakan Tambahan Ternak Ruminansia
Authors: Sarungu Yunus Tonapa , Ngatin Agustinus , Sihombing Rony Pasonang 
Published: June 2021

ABSTRAK

Jerami adalah limbah tanaman padi yang dapat digunakan sebagai bahan pakan ternak. Agar jerami tidak mengalami pembusukan, maka dilakukan proses fermentasi. Fermentasi merupakan proses pengubahan suatu zat dengan bantuan mikroorganisme dengan menghasilkan karbohidrat. Fermentasi divariasikan dengan waktu 7, 15 dan 21 hari menggunakan probiotik EM4 dan starbio. Rasio perbandingan bahan jerami dan probiotik yaitu 10:1. Dilakukan pengamatan pada hasil fermentasi untuk kandungan protein, karbohidrat sederhana, dan kadar air. Hasil penelitian menunjukkan bahwa jerami hasil fementasi berwarna cokelat, kadar protein dan glukosa meningkat. Kadar protein dengan penambahan probiotik EM4 naik dari 5,775% menjadi 18,06% dan penambahan starbio menaikkan kadar protein menjadi 14,07%. Fermentasi jerami dengan penambahan EM4 lebih efektif daripada starbio. Waktu fermentasi yang paling efektif adalah 15 hari.

Kata kunci: Jerami, fermentasi, probiotik, EM4, starbio

ABSTRACT

Straw is rice crop waste which can be used as animal feed materials. To avoid straw to decay, the fermentation process is carried out. Fermentation is the process of changing a substance with the help of microorganisms to produce carbohydrates. Fermentation was varied for 7, 15 and 21 days using EM4 and starbio probiotics. The ratio of straw and probiotic is 10: 1. The results of fermentation were observed for protein, simple carbohydrates, and water content. The results showed that fermentation resulted in brown colour and icreases of protein and glucose levels. Protein levels with the addition of EM4 probiotics increase from 5.775% to 18.06% and addition of starbio increases the protein levels to 14.07%. Straw fermentation with the addition of EM4 is more effective than starbio. The most effective fermentation time is 15 days.

Keywords: Straw, fermentation, probiotics, EM4, starbio,
Rotational stability of thoracolumbar junction fixation systems
Authors: Afaunov A. A. , Takhmazyan K. K. , Mukhanov M. L. , Basankin I. V. , Ageyev M. Yu. 
Published: June 2021

Objective To compare the rotational stability of fusion constructs using bisegmental fixation of Th12-L2 vertebrae with anterior stabilization or pedicle screw fixation.Material and Methods The strength, rigidity and limit of elasticity in the “injured vertebral motion segments (VMS) – bisegmental anterior stabilization” system under dislocating rotational loads were estimated. The data obtained were compared with the similar characteristics of the “injured VMS – bisegmental 4-screw transpedicular metal construction” system and intact spine segments.Results Under rotational loads the limits of elasticity of injured spine segments of Th12-L2 with anterior stabilization and transpedicular screw fixation (TSF) is 45.5 and 41.7%, respectively, and the general strength is 66.4% and 80%, respectively, as compared with those intact VMS. Rigidity parameters of anterior-stabilized and pedicle screw fixated VMS with unstable damage of L1 are 60.2 and 93.9%, accordingly, in comparison with those intact VMS.Conclusion No significant differences were observed between bisegmental anterior stabilization and bisegmental pedicle screw fixation of thoracolumbar junction in terms of the key mechanical properties. When treating patients with unstable thoracolumbar spine injuries using bisegmental anterior stabilization or transpedicular fixation with 4-screw spinal system possible rotation motion amplitude of operated segments must not exceed 50% of maximum physiological limits.