bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bound-state solutions and thermal properties of the modified Tietz–Hua potential
Authors: Onate C. A. , Onyeaju M. C. , Omugbe E. , Okon I. B. , Osafile O. E. 
Published: January 2021

AbstractAn approximate solutions of the radial Schrödinger equation was obtained under a modified Tietz–Hua potential via supersymmetric approach. The effect of the modified parameter and optimization parameter respectively on energy eigenvalues were graphically and numerically examined. The comparison of the energy eigenvalues of modified Tietz–Hua potential and the actual Tietz–Hua potential were examined. The ro-vibrational energy of four molecules were also presented numerically. The thermal properties of the modified Tietz–Hua potential were calculated and the effect of temperature on each of the thermal property were examined under hydrogen fluoride, hydrogen molecule and carbon (ii) oxide. The study reveals that for a very small value of the modified parameter, the energy eigenvalues of the modified Tietz–Hua potential and that of the actual Tietz–Hua potential are equivalent. Finally, the vibrational energies for Cesium molecule was calculated and compared with the observed value. The calculated results were found to be in good agreement with the observed value.
Insect derived extra oral GH32 plays a role in susceptibility of wheat to Hessian fly
Authors: Subramanyam Subhashree , Nemacheck Jill A. , Bernal-Crespo Victor , Sardesai Nagesh 
Published: January 2021

AbstractThe Hessian fly is an obligate parasite of wheat causing significant economic damage, and triggers either a resistant or susceptible reaction. However, the molecular mechanisms of susceptibility leading to the establishment of the larvae are unknown. Larval survival on the plant requires the establishment of a steady source of readily available nutrition. Unlike other insect pests, the Hessian fly larvae have minute mandibles and cannot derive their nutrition by chewing tissue or sucking phloem sap. Here, we show that the virulent larvae produce the glycoside hydrolase MdesGH32 extra-orally, that localizes within the leaf tissue being fed upon. MdesGH32 has strong inulinase and invertase activity aiding in the breakdown of the plant cell wall inulin polymer into monomers and converting sucrose, the primary transport sugar in plants, to glucose and fructose, resulting in the formation of a nutrient-rich tissue. Our finding elucidates the molecular mechanism of nutrient sink formation and establishment of susceptibility.
Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model
Authors: Keele Gregory R. , Prokop Jeremy W. , He Hong , Holl Katie , Littrell John , Deal Aaron W. , Kim Yunjung , Kyle Patrick B. , Attipoe Esinam , Johnson Ashley C. , Uhl Katie L. , Sirpilla Olivia L. , Jahanbakhsh Seyedehameneh , Robinson Melanie , Levy Shawn , Valdar William , Garrett Michael R. , Solberg Woods Leah C. 
Published: January 2021

AbstractChronic kidney disease (CKD), which can ultimately progress to kidney failure, is influenced by genetics and the environment. Genes identified in human genome wide association studies (GWAS) explain only a small proportion of the heritable variation and lack functional validation, indicating the need for additional model systems. Outbred heterogeneous stock (HS) rats have been used for genetic fine-mapping of complex traits, but have not previously been used for CKD traits. We performed GWAS for urinary protein excretion (UPE) and CKD related serum biochemistries in 245 male HS rats. Quantitative trait loci (QTL) were identified using a linear mixed effect model that tested for association with imputed genotypes. Candidate genes were identified using bioinformatics tools and targeted RNAseq followed by testing in a novel in vitro model of human tubule, hypoxia-induced damage. We identified two QTL for UPE and five for serum biochemistries. Protein modeling identified a missense variant within Septin 8 (Sept8) as a candidate for UPE. Sept8/SEPTIN8 expression increased in HS rats with elevated UPE and tubulointerstitial injury and in the in vitro hypoxia model. SEPTIN8 is detected within proximal tubule cells in human kidney samples and localizes with acetyl-alpha tubulin in the culture system. After hypoxia, SEPTIN8 staining becomes diffuse and appears to relocalize with actin. These data suggest a role of SEPTIN8 in cellular organization and structure in response to environmental stress. This study demonstrates that integration of a rat genetic model with an environmentally induced tubule damage system identifies Sept8/SEPTIN8 and informs novel aspects of the complex gene by environmental interactions contributing to CKD risk.
Synergistic activation of mutant TERT promoter by Sp1 and GABPA in BRAFV600E-driven human cancers
Authors: Wu Yongxing , Shi Liang , Zhao Yuelei , Chen Pu , Cui Rongrong , Ji Meiju , He Nongyue , Wang Maode , Li Gang , Hou Peng 
Published: January 2021

AbstractThe activating TERT promoter mutations and BRAFV600E mutation are well-established oncogenic alterations in human cancers. Coexistence of BRAFV600E and TERT promoter mutations is frequently found in multiple cancer types, and is strongly associated with poor patient prognosis. Although the BRAFV600E-elicited activation of ERK has been demonstrated to contribute to TERT reactivation by maintaining an active chromatin state, it still remains to be addressed how activated ERK is selectively recruited to mutant TERT promoter. Here, we report that transcription factor GABPA mediates the regulation of BRAFV600E/MAPK signaling on TERT reactivation by selectively recruiting activated ERK to mutant TERT promoter, where activated ERK can phosphorylate Sp1, thereby resulting in HDAC1 dissociation and an active chromatin state. Meanwhile, phosphorylated Sp1 further enhances the binding of GABPA to mutant TERT promoter. Taken together, our data indicate that GABPA and Sp1 synergistically activate mutant TERT promoter, contributing to tumorigenesis and cancer progression, particularly in the BRAFV600E-driven human cancers. Thus, our findings identify a direct mechanism that bridges two frequent oncogenic alterations together in TERT reactivation.
RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization
Authors: Alqassim Emad Y. , Sharma Shraddha , Khan A. N. M. Nazmul H. , Emmons Tiffany R. , Cortes Gomez Eduardo , Alahmari Abdulrahman , Singel Kelly L. , Mark Jaron , Davidson Bruce A. , Robert McGray A. J. , Liu Qian , Lichty Brian D. , Moysich Kirsten B. , Wang Jianmin , Odunsi Kunle , Segal Brahm H. , Baysal Bora E. 
Published: January 2021

AbstractPro-inflammatory M1 macrophage polarization is associated with microbicidal and antitumor responses. We recently described APOBEC3A-mediated cytosine-to-uracil (C > U) RNA editing during M1 polarization. However, the functional significance of this editing is unknown. Here we find that APOBEC3A-mediated cellular RNA editing can also be induced by influenza or Maraba virus infections in normal human macrophages, and by interferons in tumor-associated macrophages. Gene knockdown and RNA_Seq analyses show that APOBEC3A mediates C>U RNA editing of 209 exonic/UTR sites in 203 genes during M1 polarization. The highest level of nonsynonymous RNA editing alters a highly-conserved amino acid in THOC5, which encodes a nuclear mRNA export protein implicated in M-CSF-driven macrophage differentiation. Knockdown of APOBEC3A reduces IL6, IL23A and IL12B gene expression, CD86 surface protein expression, and TNF-α, IL-1β and IL-6 cytokine secretion, and increases glycolysis. These results show a key role of APOBEC3A cytidine deaminase in transcriptomic and functional polarization of M1 macrophages.
Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors
Authors: Matsuo Tomohiko , Isosaka Tomoko , Tang Lijun , Soga Tomoyoshi , Kobayakawa Reiko , Kobayakawa Ko 
Published: January 2021

AbstractInnate fear intimately connects to the life preservation in crises, although this relationships is not fully understood. Here, we report that presentation of a supernormal innate fear inducer 2-methyl-2-thiazoline (2MT), but not learned fear stimuli, induced robust systemic hypothermia/hypometabolism and suppressed aerobic metabolism via phosphorylation of pyruvate dehydrogenase, thereby enabling long-term survival in a lethal hypoxic environment. These responses exerted potent therapeutic effects in cutaneous and cerebral ischemia/reperfusion injury models. In contrast to hibernation, 2MT stimulation accelerated glucose uptake in the brain and suppressed oxygen saturation in the blood. Whole-brain mapping and chemogenetic activation revealed that the sensory representation of 2MT orchestrates physiological responses via brain stem Sp5/NST to midbrain PBN pathway. 2MT, as a supernormal stimulus of innate fear, induced exaggerated, latent life-protective effects in mice. If this system is preserved in humans, it may be utilized to give rise to a new field: “sensory medicine.”
Poirierite, a dense metastable polymorph of magnesium iron silicate in shocked meteorites
Authors: Tomioka Naotaka , Bindi Luca , Okuchi Takuo , Miyahara Masaaki , Iitaka Toshiaki , Li Zhi , Kawatsu Tsutomu , Xie Xiande , Purevjav Narangoo , Tani Riho , Kodama Yu 
Published: January 2021

AbstractA dense magnesium iron silicate polymorph with a structure intermediate between olivine, ringwoodite, and wadsleyite was theoretically predicted about four decades ago. As this group of minerals constitute the major component of shocked meteorites, constraining their transitional forms and behaviour is of potential importance for understanding impact events on their parent bodies. Here we use high-resolution transmission electron microscopy techniques and single-crystal X-ray diffraction analyses to identify naturally occurring examples of this mineral – recently named poirierite – in shocked chondritic meteorites. We observe nanoscale lamellar poirierite topotactically intergrown within wadsleyite, and additionally within ringwoodite as recently reported. Our results confirm the intermediate structure of poirierite and suggest it might be a relay point in the shear transformations between its polymorphs. We propose that poirierite formed during rapid decompression at relatively low temperature in retrograde shock metamorphism of the meteorites.
Flux variability from ejecta in structured relativistic jets with large-scale magnetic fields
Authors: Fichet de Clairfontaine G. , Meliani Z. , Zech A. , Hervet O. 
Published: January 2021

Context. Standing and moving shocks in relativistic astrophysical jets are very promising sites for particle acceleration to large Lorentz factors and for the emission from the radio up to the γ-ray band. They are thought to be responsible for at least part of the observed variability in radio-loud active galactic nuclei.
Aims. We aim to simulate the interactions of moving shock waves with standing recollimation shocks in structured and magnetized relativistic jets and to characterize the profiles of connected flares in the radio light curve.
Methods. Using the relativistic magneto-hydrodynamic code MPI-AMRVAC and a radiative transfer code in post-processing, we explore the influence of the magnetic-field configuration and transverse stratification of an over-pressured jet on its morphology, on the moving shock dynamics, and on the emitted radio light curve. First, we investigate different large-scale magnetic fields with their effects on the standing shocks and on the stratified jet morphology. Secondly, we study the interaction of a moving shock wave with the standing shocks. We calculated the synthetic synchrotron maps and radio light curves and analyze the variability at two frequencies 1 and 15.3 GHz and for several observation angles. Finally, we compare the characteristics of our simulated light curves with radio flares observed from the blazar 3C 273 with the Owens Valley Radio Observatory and Very Long Baseline Array in the MOJAVE survey between 2008 and 2019.
Results. We find that in a structured over-pressured relativistic jet, the presence of the large-scale magnetic field structure changes the properties of the standing shock waves and leads to an opening in the jet. The interaction between waves from inner and outer jet components can produce strong standing shocks. When crossing such standing shocks, moving shock waves accompanying overdensities injected in the base of the jet cause very luminous radio flares. The observation of the temporal structure of these flares under different viewing angles probes the jet at different optical depths. At 1 GHz and for small angles, the self-absorption caused by the moving shock wave becomes more important and leads to a drop in the observed flux after it interacts with the brightest standing knot. A weak asymmetry is seen in the shape of the simulated flares, resulting from the remnant emission of the shocked standing shocks. The characteristics of the simulated flares and the correlation of peaks in the light curve with the crossing of moving and standing shocks favor this scenario as an explanation of the observed radio flares of 3C 273.
Growth Promotion and Increased ATP-Binding Cassette Transporters
Expression by Liraglutide in Triple Negative Breast Cancer Cell Line
MDA-MB-231
Authors: Shadboorestan Amir , Tarighi Parastoo , Koosha Mahsa , Faghihi Homa , Ghahremani Mohammad Hossein , Montazeri Hamed 
Published: January 2021

Background Glucagon-like petide-1 (GLP-1) agonists such as liraglutide
are widely employed in type 2 diabetes due to their glucose reducing
properties and small risk of hypoglycemia. Recently, it has been shown that
GLP-1agonists can inhibit breast cancer cells growth. Nonetheless, concerns
are remained about liraglutide tumor promoting effects as stated by
population studies.
Material and Methods We evaluated the effects liraglutide on
proliferation of MDA-MB-231 cells by MTT assay and then ATP-binding cassette
(ABC) transporters expressions assessed by Real time PCR. Statistical
comparisons were made using one-way analysis of variance followed by a post
hoc Dunnett test.
Results Here, we report that liraglutide can stimulate the growth of
highly invasive triple negative cell line MDA-MB-231; which can be
attributed to AMPK-dependent epithelial-mesenchymal transition (EMT)
happening in MDA-MB-231 context. Toxicity effects were only observed with
concentrations far above the serum liraglutide concentration. ATP-binding
cassette (ABC) transporters expressions were upregulated, indicating the
possible drug resistance and increased EMT.
Conclusion In conclusion, these results suggest that liraglutide
should be used with caution in patients who are suffering or have the
personal history of triple negative breast cancer. However, more detailed
studies are required to deepen understanding of liraglutide consequences in
triple negative breast cancer. ▶Graphical Abstract.
Nativised structural patterns of make light verb construction in Malaysian English
Authors: Ong Christina Sook Beng , Abdul Rahim Hajar 
Published: January 2021

AbstractThis study investigated nativised structural patterns of light verb constructions (LVCs) in Malaysian English using a corpus-based, descriptive approach to analyse grammatical innovations. To facilitate the analysis, a 100-million-word general corpus comprising threads from Lowyat.Net, a popular Internet forum in Malaysia, was created, and the British National Corpus (BNC) was used as the reference corpus. Using the Sketch Engine corpus tool, the three most frequently occurringmakeLVCs in the Malaysian English corpus were identified. The data was analysed to reveal the differences between the structures ofmakeLVC in Malaysian English and its prototypical structure. The findings show that besides the non-isomorphic deverbal noun form,makeLVCs in Malaysian English prefer taking the basic constituents of an LVC. Nativised LVCs are essentially those with zero articles and isomorphic deverbal nouns taking definite articles, determiners, and descriptive adjectives in their modifier slots. The zero article LVC is the most common nativised structure pattern due to the influence of substrate languages in Malaysian English.
Speech perception in noise, gap detection and amplitude modulation detection in suspected hidden hearing loss
Authors: Vijayasarathy Srikar , Mohan Meghana , Nagalakshmi Pratibha , Barman Animesh 
Published: January 2021

Objectives
The objectives of the study were to investigate speech in noise perception, gap detection, and amplitude modulation detection in construction workers exposed to occupational noise, but had normal peripheral hearing. Hidden hearing loss characterized by suprathreshold processing deficits in the absence of affected hearing sensitivity was thus probed.

Materials and methods
Participants were 12 construction workers with chronic exposure to high levels of noise, but had hearing sensitivity and distortion product otoacoustic emissions within normal limits. The control group consisted of age-matched participants with no significant noise exposure. Speech in noise perception was assessed at 0 dB SNR using bi-syllabic words and Gap detection as well as Amplitude modulation detection were assessed with broadband noise.

Results
Speech in noise perception and Gap detection thresholds were significantly poorer in the noise-exposed group while Amplitude modulation detection performance did not differ significantly between the two groups.

Conclusions
Affected suprathreshold perception in the absence of peripheral hearing loss suggests the presence of a hidden hearing loss due to noise exposure. However, the disorder is subtle, and the variability is high, leading to heterogeneity in findings across studies. Studies with higher power and active replications are required to characterize cochlear synaptopathy better.
Attributes beyond Attitudes: Personality Traits on the US Supreme Court
Authors: Hall Matthew E. K. , Hollibaugh Gary E. , Klingler Jonathan D. , Ramey Adam J. 
Published: January 2021

AbstractModels of behavior on the US Supreme Court almost universally assume that justices’ behavior depends, at least in part, on the characteristics of individual justices. However, few prior studies have attempted to assess these characteristics beyond ideological preferences. In contrast, we apply recent advances in machine learning to develop and validate measures of the Big Five personality traits for Supreme Court justices serving during the 1946 through 2015 terms based on the language in their written opinions. We then conduct an empirical application to demonstrate the importance of these Supreme Court Individual Personality Estimates and discuss their proper use.
Cross-section investigation of MgOH (X
2
Σ

+
) fine-structure excitation by helium
Authors: Naouai Manel , Jrad Abdelhak , Najar Faouzi , Hammami Kamel 
Published: January 2021

Abstract
Inelastic fine rotational cross-sections of the magnesium monohydroxide (MgOH) molecule by collision with helium (He) atoms are investigated. We illustrate the two-dimensional potential energy surface (2D-PES) for the MgOH–He interacting system. The ab initio 2D-PES is computed using the restricted coupled cluster approach with single, double, and perturbative triple excitation connected to an augmented-correlation consistent-polarized valence quadruple zeta Gaussian basis set. One minimum located at (θ = 0°; R = 8.25 bohr) on the side of the hydrogen atom is observed. Inelastic cross-sections are investigated for the 13 first fine rotational levels for a total energy up to 100 cm−1. Propensity rules toward odd ΔN and ΔN = Δj are found.
Oxygen annealing induced changes in defects within β-Ga2O3 epitaxial films measured using photoluminescence
Authors: Sun Rujun , Ooi Yu Kee , Ranga Praneeth , Bhattacharyya Arkka , Krishnamoorthy Sriram , Scarpulla Michael A 
Published: January 2021

Abstract
In this work, we use photoluminescence spectroscopy (PL) to monitor changes in the UV, blue, and green emission bands from n-type (010) Ga2O3 films grown by metalorganic vapor phase epitaxy induced by annealing at different temperatures under O2 ambient. Annealing at successively higher temperatures decreases the overall PL yield and UV intensity at nearly the same rates, indicating the increase in the formation of at least one non-radiative defect type. Simultaneously, the PL yield ratios of blue/UV and green/UV increase, suggesting that defects associated with these emissions increase in concentration with O2 annealing. Utilizing the different absorption coefficients of 240 and 266 nm polarization-dependent excitation, we find activation energy for the generation of non-radiative defects of 1.34 eV in the bulk but 2.53 eV near the surface. We also deduce activation energies for the green emission-related defects of 1.20 eV near the surface and 2.21 eV at low temperatures and 0.74 eV at high temperatures through the films, whereas the blue-related defects have activation energy in the range 0.72–0.77 eV for all depths. Lastly, we observe hillock surface morphologies and Cr diffusion from the substrate into the film for temperatures above 1050 °C. These observations are consistent with the formation and diffusion of V
Ga and its complexes as a dominant process during O2 annealing, but further work will be necessary to determine which defects and complexes provide radiative and non-radiative recombination channels and the detailed kinetic processes occurring at surfaces and in bulk amongst defect populations.
Multi-orbital tight binding model for the electronic and optical properties of armchair graphene nanoribbons in the presence of a periodic potential
Authors: Hieu Nguyen N , Shih Po-Hsin , Do Thi-Nga , Nguyen Chuong V 
Published: January 2021

Abstract
The influences of an external electric field with uniform or modulated potential on the electronic and optical properties of armchair graphene nanoribbons (GNRs) are explored using the multi-orbital tight-binding Hamiltonian. The interplay between an electric field and interaction between (s, p

x
, p

y
, p

z
) orbitals remarkably enriches the main features of band structures and absorption spectra. The applied electric field can notably alter the energy dispersions of π and σ bands, leading to the deformation of band-edge states, open and close of a band gap, and modification of the Fermi energy. The vertical optical excitations happen among the π bands, while their available channels depend on the Fermi level which is controlled by the σ-edge bands and a finite potential. With the rich and unique properties, GNRs are suitable candidates for applications in the fields of photodetectors, nanoelectronics, and spintronics. The calculated results are expected to be examined by the angle-resolved photoemission spectroscopies and optical spectroscopies.