bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS PEMASARAN DIGITAL DAN CITRA MEREK TERHADAP KEPUTUSAN PEMBELIAN
Authors: Tri Mahendra Prasetya , Ningtyas Hesty Ishmi 
Published: January 2025

Perkembangan informasi dan teknologi yang semakin pesat memberikan pengaruh terhadap berbagai aspek, termasuk dalam bidang kuliner yang semakin banyak inovasi dan minat konsumen. Kuliner merupakan salah satu bisnis yang banyak diminati karena memiliki prospek yang bagus, saat ini teh menjadi primadona peluang bisnis yang sangat menguntungkan dalam beberapa tahun belakangan ini, dengan menggunakan teh para pelaku bisnis dapat mengembangkan budaya dalam mengkonsumsi teh kembali. Penelitian ini bertujuan untuk mengetahui pengaruh pemasaran digital, dan citra merek terhadap keputusan pembelian (studi pada Es Teh Indonesia Bojonegoro). Penelitian ini dilakukan selama 3 (tiga) bulan dengan fokus pada pemasaran digital dan citra merek terhadap keputusan pembelian, dengan menggunakan pendekatan kuantitatif. Populasi dalam penelitian ini adalah konsumen yang berkunjung dan melakukan pembelian di Es Teh Indonesia Bojonegoro. Metode pengumpulan data yang digunakan dalam penelitian ini adalah dengan kuesioner yang disebarkan kepada 97 responden yang dipilih dengan menggunakan purposive sampling. Dalam penelitian menggunakan aplikasi SPSS 26. Metode dalam analisis data menggunakan Uji Instrumen, uji normalitas, uji asumsi klasik, analisis regresi linier berganda, uji hipotesis dan koefisien determinasi (R2). Hasil penelitian menunjukkan bahwa pemasaran digital dan citra merek memiliki pengaruh yang signifikan terhadap keputusan pembelian baik secara parsial maupun simultan.
Evaluation of Heat Stress Impacts on Physiological Responses in Two Indigenous Nigerian Goats
Authors: Tella Adetunmbi , Dandara Gazali B , Gabriel Godfrey O , Oluwadele Joshua , Osunkeye Jacob O 
Published: January 2025

Stress comes in many forms for livestock, including physical, chemical, nutritional, thermal, and psychological stress. Changes in skin temperature, heart rate, respiration rate, and rectal temperature are indicators of physiological reactions to heat stress. Regression investigation of the physiological reactions of Nigerian native goat breeds (West African dwarf and Red Sokoto) to heat stress was the goal of this study. 400 goats (200 West African Dwarf and 200 Red Sokoto) from Osun, Ondo, and Ekiti states in Nigeria were subjected to varying climatic conditions (temperature and humidity) in order to gather data on physiological indicators (rectal temperature, pulse rate, and respiration rate). An analysis of variance (ANOVA) was performed to evaluate variations in the physiological parameters, and the temperature and humidity index (THI) was computed for the study's environmental conditions. The coefficient of determination (R2), which represents the accuracy of the predictions, was calculated using regression analysis. The results demonstrated that both breeds' physiological characteristics reacted similarly, with higher THI values considerably increasing heart rate, respiration rate, and rectal temperature. Regression evaluation indicated that THI had a significant (P ≤ 0.05) and positive effect on heart rate (R² = 0.545), respiration rate (R² = 0.32), and rectal temperature (R² = 0.146) for the Red Sokoto breed. These physiological adaptations enable goats to survive and thrive in challenging and variable environments.
Peran Kepala Sekolah dalam Mengembangkan Lembaga melalui Kurikulum Merdeka
Authors: Wathon A 
Published: January 2025

This study investigates the pivotal role of school principals in advancing educational institutions through the implementation of the Kurikulum Merdeka (Independent Curriculum). It focuses on how principals lead, manage resources, and foster innovation to enhance teaching and learning processes. A qualitative approach was adopted, utilizing in-depth interviews, observations, and document analysis in schools that have implemented the Kurikulum Merdeka. The findings highlight that principals serve as transformational leaders, effectively shaping institutional vision, inspiring teacher collaboration, and engaging stakeholders. They play a critical role in managing changes associated with curriculum implementation, ensuring a smooth transition by providing continuous training and professional development for teachers. Through strategic leadership, principals motivate teachers to embrace innovative teaching strategies, fostering a dynamic and engaging learning environment. The implementation of the Kurikulum Merdeka under principal leadership has demonstrated significant improvements in learning quality. It has cultivated a creative and flexible learning atmosphere, promoting student independence and critical thinking. By prioritizing collaboration and leveraging resources efficiently, principals have successfully aligned institutional goals with the curriculum's objectives. This study underscores the importance of strategic and adaptive leadership in addressing the challenges of curriculum reform. Principals’ ability to lead change and optimize institutional potential is critical in achieving educational excellence. The findings suggest that with effective leadership, schools can maximize the benefits of the Kurikulum Merdeka, creating environments that empower students and support holistic development.
Blaski i cienie życia renesansowego poety Jerzego Sabinusa
Authors: Chrobot Agata 
Published: January 2025

Jerzy Sabinus (prawdziwe nazwisko: Georg Schuler; ur. 23 IV 1508r. w Brandenburgu – zm. 2 XII 1560r. we Frankfurcie nad Odrą) był dyplomatą, poetą, cenionym znawcą literatury greckiej i rzymskiej, jej tłumaczem, edytorem i komentatorem oraz pierwszym rektorem Uniwersytetu Albertyna w Królewcu.
Poezja Sabinusa pełna jest opisów różnych punktów zwrotnych w życiu poety, najważniejsze to: studia na Uniwersytecie w Wittenberdze, relacje przyjacielskie ze swoim nauczycielem - Filipem Melanchtonem, ślub z Anną Melanchton, ważna dla każdego humanisty podróż do Italii, objęcie stanowiska rektora na nowo założonym Uniwersytecie w Królewcu i związana z tym przeprowadzka, śmierć żony, wyjazd z Królewca i ponowny powrót oraz odbyte misje dyplomatyczne.
Sabinus kształcił się na uniwersytecie w Wittenberdze, gdzie poznał Filipa Melanchtona, a w roku 1536 ożenił się z jego córką Anną (Elegie III 1-7). Anna Melanchton była kobietą nieprzeciętną, bardzo dobrze wykształconą i niebywale zdolną. Poeta w wielu utworach mocno akcentuje pochodzenie Anny, ożenek z córką jednego z największych uczonych z pewnością przysporzył mu sławy, do chrztu niósł Annę sam Marcin Luter (El. VI 7).
Kolejnym punktem zwrotnym dla poety była podróż do Italii, którą odbył w latach 1533-1534 (Hodoeporicon itineris Italici). Sabinus wyprawił się w tę długą i niebezpieczną podróż w celu edukacji oraz aby zawrzeć nowe znajomości, dzięki którym został włączony do grona elity humanistycznej ówczesnej Europy. Podczas tej peregrynacji poznał Aleandra, Lazzarra Bonamica, Joannesa Baptistę Egnatiusa i weneckiego kardynała Piotra Bemba, z którym przyjaźnił się do śmierci przyjaciela.
Kolejną zmianą w życiu poety była przeprowadzka do Królewca i objęcie stanowiska pierwszego rektora Uniwersytetu Albertyna w Królewcu w 1544 roku (El. V 6-10, VI 3,5, 6).
W Królewcu 27 lutego 1547 roku w wieku 25 lat zmarła żona poety Anna z domu Melanchton. Po czterech latach sprawowania urzędu rektora w roku 1547 zrezygnował z tej funkcji i opuścił Królewiec. W latach 1552 i 1553 powrócił tam ponownie na stanowisko rektora.
W artykule przedstawiam zarówno te dobre, jak i te złe momenty w życiu poety, które rozrzucił po kartach wielu swoich utworów.
Intervención grupal para estrés en jugadores de disc golf con integración TCC/TBCS
Authors: Arratia Velarde Mario Andres , González Ramírez Mónica Teresa 
Published: January 2025

El presente estudio evalúa la eficacia de cuatro sesiones de un tratamiento integrativo de la terapia cognitivo conductual junto a la terapia centrada en soluciones en el manejo del estrés en jugadores de disc golf de alto rendimiento. Se presenta evidencia bibliográfica que fundamenta la posibilidad de un tratamiento integrado efectivo para la reducción de estrés en atletas. Con una muestra de 7 participantes se realizó una prueba de rangos de Wilcoxon con medidas pretest y postest de cuestionarios estandarizados que miden características psicológicas relacionadas con el rendimiento deportivo, pensamiento centrado en soluciones, pensamientos negativos automáticos y estrés percibido. Los resultados mostraron un efecto significativo en reducción de pensamientos negativos automáticos (W = 21, p = 0.017), aumento de pensamiento centrado en soluciones (W = 1.5, p = 0.037) y características psicológicas relacionadas al deporte (W = 0.0, p = 0.016). No se observó un efecto significativo en la reducción de estrés percibido. Se concluye un beneficio empírico en el manejo del estrés de los atletas.
Risk factors of urinary tract infection through demographic and laboratory markers among benign prostate hyperplasia patients: a single-center study
Authors: Nasution Muhammad Andriady Saidi , Batu Rowanti Devi Trianna Lumban , Suandy Suandy , Velaro Adrian Joshua , Firsty Naufal Nandita 
Published: January 2025

Introduction: Prostate enlargement known as benign prostatic hyperplasia (BPH) increases the risk of infection in the urinary tract by obstructing or blocking the prostatic portion of the urethra. This disease becomes more common as people age.
Aim: To determine differences in the risk of urinary tract infection based on demographics and laboratory markers in patients with benign prostate hyperplasia.
Materials and methods: The present study is quantitative analytical observational research. Patients from Vita Insani Hospital’s Urology Polyclinic in Pematangsiantar during 2021–2023 made up the study’s population. In sampling, we used the purposive sampling technique.
Results: Medical records were used to gather data, which were then subjected to univariate and bivariate analyses using SPSS. The present study found that there were statistically significant differences between the neutrophil lymphocyte and the platelet-lymphocyte ratios in the incidence of urinary tract infections among BPH populations (p&lt;0.05), while other studies documented that risk factors such as monocyte-to-lymphocyte ratio, catheter use, comorbidity status, and renal functions (urea, creatinine, and GFR levels) did not show significant differences (p&gt;0.05).
Conclusion: It is expected that health workers, especially nurses in hospitals can provide information, always monitor signs of infection and apply aseptic procedures in performing catheter insertion actions to BPH patients to avoid urinary tract infections.
Use of Machine Learning Models to Predict Microaspiration Measured by Tracheal Pepsin A
Authors: Bourgault Annette , Logvinov Ilana , Liu Chang , Xie Rui , Powers Jan , Sole Mary Lou 
Published: January 2025

Background
Enteral feeding intolerance, a common type of gastrointestinal dysfunction leading to underfeeding, is associated with increased mortality. Tracheal pepsin A, an indicator of microaspiration, was found in 39% of patients within 24 hours of enteral feeding. Tracheal pepsin A is a potential biomarker of enteral feeding intolerance.

Objective
To identify predictors of microaspiration (tracheal or oral pepsin A). It was hypothesized that variables predicting the presence of tracheal pepsin A might be similar to predictors of enteral feeding intolerance.

Methods
In this secondary analysis, machine learning models were fit for 283 adults receiving mechanical ventilation who had tracheal and oral aspirates obtained every 12 hours for up to 14 days. Pepsin A levels were measured using the proteolytic enzyme assay method, and values of 6.25 ng/mL or higher were classified as indicating microaspiration. Demographics, comorbidities, and variables associated with enteral feeding were analyzed with 3 machine learning models—random forest, XGBoost, and support vector machines with recursive feature elimination—using 5-fold cross-validation tuning.

Results
Random forest for tracheal pepsin A was the best-performing model (area under the curve, 0.844 [95% CI, 0.792-0.897]; accuracy, 87.55%). The top 20 predictors of tracheal pepsin A were identified.

Conclusion
Four predictor variables for tracheal pepsin A (microaspiration) are also reported predictors of enteral feeding intolerance, supporting the exploration of tracheal pepsin A as a potential biomarker of enteral feeding intolerance. Identification of predictor variables using machine learning models may facilitate treatment of patients at risk for enteral feeding intolerance.
Point-of-Care Potassium Measurement vs Artificial Intelligence–Enabled Electrocardiography for Hyperkalemia Detection
Authors: Lin Chin , Chen Chien-Chou , Lin Chin-Sheng , Shang Hung-Sheng , Lee Chia-Cheng , Chau Tom , Lin Shih-Hua 
Published: January 2025

Background
Hyperkalemia can be detected by point-of-care (POC) blood testing and by artificial intelligence– enabled electrocardiography (ECG). These 2 methods of detecting hyperkalemia have not been compared.

Objective
To determine the accuracy of POC and ECG potassium measurements for hyperkalemia detection in patients with critical illness.

Methods
This retrospective study involved intensive care patients in an academic medical center from October 2020 to September 2021. Patients who had 12-lead ECG, POC potassium measurement, and central laboratory potassium measurement within 1 hour were included. The POC potassium measurements were obtained from arterial blood gas analysis; ECG potassium measurements were calculated by a previously developed deep learning model. Hyperkalemia was defined as a central laboratory potassium measurement of 5.5 mEq/L or greater.

Results
Fifteen patients with hyperkalemia and 252 patients without hyperkalemia were included. The POC and ECG potassium measurements were available about 35 minutes earlier than central laboratory results. Correlation with central laboratory potassium measurement was better for POC testing than for ECG (mean absolute errors of 0.211 mEq/L and 0.684 mEq/L, respectively). For POC potassium measurement, area under the receiver operating characteristic curve (AUC) to detect hyperkalemia was 0.933, sensitivity was 73.3%, and specificity was 98.4%. For ECG potassium measurement, AUC was 0.884, sensitivity was 93.3%, and specificity was 63.5%.

Conclusions
The ECG potassium measurement, with its high sensitivity and coverage rate, may be used initially and followed by POC potassium measurement for rapid detection of life-threatening hyperkalemia.
Interspecific Facilitation of Nutrient Uptake and Productivity Performance of Finger Millet-Green Gram Intercropping System under Varying Moisture Availability
Authors: Senevirathne A. G. U. N. , Dissanayaka D. M. S. B. , De Silva S. H. N. P. 
Published: January 2025

Finger mi llet (FM/ Eleusine coracana L. Gaertn.) and green gram (GG/ Vigna radiata L. Wilczek) are suitable crops to be cultivated under moisture-limited conditions. This experiment investigated the interspecific facilitation of nitrogen (N) and phosphorus (P) uptake and productivity performance of FM-GG intercropping system under moisture-s tressed conditions. In a pot experiment, two crop species were cultivated as mono-cropping and intercropping under two moisture levels (well-watered and moisture-stressed). Soil moisture in well-watered condition was maintained at 80% of field capacity, whereas moisture-stress was imposed with 40%. Plant dry weight, panicle/ grain yield, uptake of N and P, and use efficiency of those nutrients i n biomass production were measured. Moisture-stress significantly (P<0.05) decreased the panicle/grain dry weight of FM and GG. Though intercropping had no yield advantage for FM or GG either in well-watered or moisture-stressed c onditions, intercropped FM under drought stress and well-watered conditions had respectively 42% and 53% greater grai n N accumulation than those of its monocultures. FM grown with GG acquired more (P<0.05) N than those cultivated in mono-cropping system indicating the interspecif ic facilitation of N uptake by FM in intercropping. Grain N accumulation of FM was also enhanced in intercroppin g system. There were no P benefits from the intercropping. The study indicates that interspecific facilitation of nutrient uptake in FM-GG intercropping happens only for N, resulting in grain N fortification of FM. Incorporati on of legumes, particularly green gram, into FM cultivation in drought-prone areas could be a potential strategy for g rain N enrichment of FM.
REFINING HIGH-RISK MULTIPLE MYELOMA: ADVANCEMENTS IN GENOMIC, CLINICAL, AND PROGNOSTIC CRITERIA
Authors: Martino Enrica Antonia , Mele Giuseppe , Morabito Fortunato , Gentile Massimo 
Published: January 2025

Multiple myeloma (MM) is a heterogeneous disease with MM patients experiencing different clinical outcomes depending on the disease’s biological features. Novel insights into the molecular mechanisms of MM have led to the introduction of sophisticated drugs, which dramatically improved patient treatment and survival. To date, young patients with newly diagnosed MM could experience a median overall survival (OS) of 10 years. Nevertheless, a small proportion of patients still undergoes early disease progression and death. Indeed, cases defined as ultra-high-risk MM (uHRMM) and high-risk MM (HRMM) are destined for a worse outcome, with an OS of 2-3 and 3-5 years, respectively. In this regard, current risk stratification systems failed to identify this subset of patients better. The application of existing risk models has led to the identification of extremely heterogeneous categories of patients, and they have not taken into account biological and clinical differences. The concept of HRMM was initially formalized in 2015. Since then, a great effort has been made to identify those parameters whose presence pone MM patients at higher risk of developing an early relapse. The simultaneous presence of 2 or more unfavorable cytogenetic abnormalities, the identification of an extramedullary disease or the detection of circulating plasma cells, as well as high-risk gene expression profiling (GEP) signature, have shown to be well related to a worse outcome and are going to be incorporated into new prognostic systems. The introduction of the Individualized Risk Model for Multiple Myeloma (IRMMa) marks a significant advancement in the management of HRMM by integrating genomic and clinical data to tailor treatment strategies. This model demonstrates improved prognostic accuracy compared to traditional staging systems and emphasizes the importance of personalized treatment approaches. The implementation of these advanced tools is essential for enhancing precision medicine in MM and improving outcomes for patients in high-risk categories.
Interleukin 38 as a bio marker for metabolic syndrome in psoriatic patients
Authors: Mohamed Rasha I. , Abd-elmagid Wafaa M. , Mohammed Abdellatif Yomna A. , Abo elmagd Marwa A. 
Published: January 2025

Background
Metabolic syndrome (MetS) is more common comorbidity in psoriasis and a risk factor for cardiovascular disease. Interleukin 38 (IL-38) is an anti-inflammatory cytokine that has a vital role in MetS.

Aim
This research aimed to identify the possible relationship between plasma IL-38 levels in psoriatic cases and MetS development.

Methods
This case-control study included 88 adults aged greater than 18 years, divided into four groups of 22: group (1) cases with psoriasis vulgaris only, group (2) cases with psoriasis vulgaris and MetS, group (3) cases with MetS only, and group (4) healthy control subjects. All participants were subjected to full history taking, clinical assessment, laboratory investigation (fasting blood sugar, fasting triglyceride level, high-density lipoprotein), and plasma levels of IL-38 using ELISA kits.

Results
IL-38 levels were significantly decreased in each of the diseased patients (psoriasis, MetS, or both) than in controls. patients with psoriasis and MetS had the lowest level of IL-38 than those with psoriasis only or MetS only. There was a highly significant difference in the IL-38 levels among the groups (P<0.0001). In patients with psoriasis there was a significantly negative correlation between the PASI score and IL-38 levels.

Conclusion
The decreased serum level of IL-38 among psoriatic patients with MetS is more than patients with either disease alone due to its role in the pathogenesis of both conditions. Much decrease in its level in psoriatic patients can be an indicator of development of metabolic abnormalities. This opens a new scope in the treatment of both conditions using IL-38.
Comparison of using dermapen device assisted delivery of Botulinum Toxin a versus its intradermal injection in the treatment of palmar hyperhidrosis
Authors: El-Gayar Maha A. , Alashry Shereen E. , Eldahshan Reem I.M. 
Published: January 2025

Background
Hyperhidrosis (HH) is a condition characterized by excessive sweating caused by overstimulation of cholinergic receptors on eccrine glands. Primary hyperhidrosis (PH) is idiopathic, bilaterally symmetric, and affects various parts of the body. Botulinum neurotoxin-A (BTX-A) has a role in the nonsurgical management of HH. Dermapen was introduced for transdermal drug delivery.

Objective
To evaluate the clinical efficacy of Dermapen assisted delivery of BTX-A versus its intradermal injection in the treatment of primary palmar HH.

Patients and methods
A prospective intrapatient comparative study, conducted on 20 patients with bilateral palmar HH categorized into two groups, group A: left palm was treated by intradermal injection of BTX-A, group B: right palm was treated by Dermapen combined with topically applied BTX-A.

Results
Both groups had significant improvement after treatment. However, group A showed significantly better grades regarding hyperhidrosis disease severity scale, dermatology life quality index, and patient satisfaction.

Conclusion
Both methods were effective and tolerable. Intradermal injection intervention was better regarding hyperhidrosis disease severity scale, dermatology life quality index, patients satisfaction, and long-term follow-up.
Toll-like receptor 4 +896 A>G and CD14–159 C>T polymorphism in Egyptian patients with atopic dermatitis
Authors: Hasan Ahmad S. , Ragab Aml F. , Salem Hanan A. , Metwally Shereen S. , Fathy Amr M. 
Published: January 2025

Aim
To investigate the possible association of Toll-like receptor (TLR4) +896 A/G and CD14 −159C/T single nucleotide polymorphisms (SNPs) with the development of atopic dermatitis (AD) in a sample of Egyptian AD cases and to evaluate their correlation with total serum immunoglobulin E (IgE) level and disease severity.

Patients and methods
This work comprises 100 AD cases in addition to 100 patients similar in age and sex as controls. TLR4 +896 A>G rs 4986790 and CD14–159 C>T rs 2569190 polymorphisms were determined using polymerase chain reaction-restriction fragment length polymorphism.

Results
TLR4 +896 A/G genotyping, showed a statistically significant higher frequency of AG genotype (30%), AG+GG genotype (33%), and G allele (36%) in AD patients versus controls (2%) (P<0.001), with high risk to develop AD (OR =21.9, 24.1, and 21.7), respectively. CD14–159 C>T rs 2569190 genotyping, showed a higher frequency of CT, TT, and combined CT+TT genotypes in the control group (57%, 27%, 84%), versus AD patients (39%, 20%, 59%), respectively. Also, the T allele showed a statistically significant higher frequency in controls (55.5%) compared with AD patients (39.5%), (P<0.001, 0.002, <0.001, and 0.001), respectively. Still, they are not associated with the clinical features, serum IgE level, and SCORAD in all studied AD patients.

Conclusion
TLR4 (+896 A>G) rs 4986790 AG, combined AG+GG genotype, in addition to G allelomorph may be considered risky, while CD14 −159 C>T rs 2569190 (CT), (CT+TT) genotype and T allelomorph may be considered safeguarding elements against development of AD in Egyptian cases. Still, neither is associated with the clinical features, serum IgE level, or disease severity.