bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chinese Herbal Medicine Used With or Without Conventional Western Therapy for COVID-19: An Evidence Review of Clinical Studies
Authors: Liang Shi-Bing , Zhang Ying-Ying , Shen Chen , Liang Chang-Hao , Lai Bao-Yong , Dai Ning , Li Yu-Qi , Tian Zi-Yu , Zhang Xiao-Wen , Jiang Yue , Xiong Min , Zhang Ya-Peng , Zhang Ying , Robinson Nicola , Liu Jian-Ping 
Published: February 2021

Objective: To present the evidence of the therapeutic effects and safety of Chinese herbal medicine (CHM) used with or without conventional western therapy for COVID-19.Methods: Clinical studies on the therapeutic effects and safety of CHM for COVID-19 were included. We summarized the general characteristics of included studies, evaluated methodological quality of randomized controlled trials (RCTs) using the Cochrane risk of bias tool, analyzed the use of CHM, used Revman 5.4 software to present the risk ratio (RR) or mean difference (MD) and their 95% confidence interval (CI) to estimate the therapeutic effects and safety of CHM.Results: A total of 58 clinical studies were identified including RCTs (17.24%, 10), non-randomized controlled trials (1.72%, 1), retrospective studies with a control group (18.97%, 11), case-series (20.69%, 12) and case-reports (41.38%, 24). No RCTs of high methodological quality were identified. The most frequently tested oral Chinese patent medicine, Chinese herbal medicine injection or prescribed herbal decoction were: Lianhua Qingwen granule/capsule, Xuebijing injection and Maxing Shigan Tang. In terms of aggravation rate, pooled analyses showed that there were statistical differences between the intervention group and the comparator group (RR 0.42, 95% CI 0.21 to 0.82, six RCTs; RR 0.38, 95% CI 0.23 to 0.64, five retrospective studies with a control group), that is, CHM plus conventional western therapy appeared better than conventional western therapy alone in reducing aggravation rate. In addition, compared with conventional western therapy, CHM plus conventional western therapy had potential advantages in increasing the recovery rate and shortening the duration of fever, cough and fatigue, improving the negative conversion rate of nucleic acid test, and increasing the improvement rate of chest CT manifestations and shortening the time from receiving the treatment to the beginning of chest CT manifestations improvement. For adverse events, pooled data showed that there were no statistical differences between the CHM and the control groups.Conclusion: Current low certainty evidence suggests that there maybe a tendency that CHM plus conventional western therapy is superior to conventional western therapy alone. The use of CHM did not increase the risk of adverse events.
Psychometric Properties of the Suicide Stroop Task in a Chinese College Population
Authors: Niu Lu , Feng Xia , Jia Zhouxin , Yu Yu , Zhou Liang 
Published: February 2021

ObjectiveThis study aimed to test the psychometric properties of the suicide stroop task in a Chinese college population.MethodsCollege students (n = 121) who were in the 1st–4th grade, fluent in Chinese, and without color blindness were recruited from a university in Guangzhou, China from September to December 2019. Participants were administered the suicide stroop task at baseline and 1-month follow-up.ResultsThe suicide stroop task showed excellent internal reliability (Cronbach’s α ranged from 0.940 to 0.953). However, the suicide stroop task did not reveal suicide-related attentional biases among current suicide ideators and was not significantly associated with the severity of suicidal ideation, depression, hopelessness, nor anhedonia (all p values &gt; 0.05), indicating a lack of concurrent validity for the task. Additionally, the two-time data of interference scores could not generate intraclass correlation coefficients (ICCs) due to a negative average covariance among data, which indicated poor test–retest consistency for the task.ConclusionThe results of this study did not support the use of the suicide stroop task on the identification of suicidal risk among Chinese college students. It is crucial to assess the psychometric properties of behavioral measures rigorously as self-report measures before large applications in clinical and community settings.
Role of Happiness: Mediating Digital Technology and Job Performance Among Lecturers
Authors: Bangun Yuni Ros , Pritasari Adita , Widjaja Fransisca Budyanto , Wirawan Christina , Wisesa Anggara , Ginting Henndy 
Published: February 2021

PurposeHappiness has been the most important goal for humans throughout history and is a significant issue among university lecturers facing a rapid digital technology change. It is usually described as a well-being state, feeling satisfied and contented, consisting of positive happenings in an individual’s life concerning the social, spiritual, economic, psychological, and physiological spheres. This research examines the relationship between happiness, attitudes toward technology, and lecturers’ job performance in higher education.Design and MethodologyThis research design was a cross-sectional design that asked the respondents from lecturers of Institut Teknologi Bandung, one of the best universities with technology-based education in Indonesia, to complete a group of well-validated questionnaires. The questionnaires mentioned earlier include the Oxford Happiness Questionnaire and three other newly constructed questionnaires, made to measure attitude toward digital technology, job satisfaction, and job performance.FindingsThis research confirmed that happiness fully mediated the relationship between attitude toward digital technology and job performance. Additionally, this research also confirmed that happiness partially mediated the relationship between job satisfaction and job performance. These results implied that a positive attitude toward digital technology and higher job satisfaction would lead to happier lecturers who increase their job performance.OriginalityThis study suggests that a positive attitude toward technology has a higher impact than job satisfaction as determinant factors of happiness and its association with lecturers’ job performance such as universities, especially Institut Teknologi Bandung as a technologically advanced workplace environment. Additionally, the Oxford Happiness Questionnaire framework, frequently used in studies of other countries, is now being used in the context of an Indonesian case study, precisely to measure happiness among lecturers in Indonesian higher education.
A Randomized Controlled Trial Evaluating the Effectiveness of a Short Video-Based Educational Program for Improving Mental Health Literacy Among Schoolteachers
Authors: Ueda Junya , Yamaguchi Satoshi , Matsuda Yasuhiro , Okazaki Kosuke , Morimoto Tsubasa , Matsukuma Seiya , Sasaki Tsukasa , Kishimoto Toshifumi 
Published: February 2021

Background: Mental illness-related stigma represents a barrier to seeking and receiving appropriate mental health care. Mental health literacy (MHL) can improve mental health knowledge, decrease stigmatizing attitudes, and enhance help-seeking behavior. Starting from 2022, mental illness-related education is due to be introduced in high schools in Japan. For this current situation, we conducted a parallel group, randomized controlled trial to examine the effectiveness of MHL educational program for teachers.Methods: The educational program described in this study comprised a 50-min video lesson designed to improve teachers' MHL. All participants were schoolteachers and were assigned either to an educational group or a waitlist control group. The assessment was conducted for both groups twice: first at baseline and then at 1-h post-intervention. The outcome measures for this trial were changes in knowledge, attitudes, and intended behaviors.Results: The educational group showed a greater improvement in knowledge regarding mental health than did the control group. The program was not effective for decreasing stigma toward mental illness. However, the educational group showed an increased intention to assist students with depression.Limitations: No long-term follow-up was implemented, which means the persistence of the educational program's effect could not be determined. Further, we could not report whether the program induced a change in teachers' behaviors regarding providing support for their students.Conclusions: The short video-based MHL educational program could improve schoolteachers' MHL and increase their intention to assist students. These findings can help in the development of similar educational programs in countries/regions experiencing similar issues regarding mental health.
Depression in Alzheimer's Disease: A Delphi Consensus on Etiology, Risk Factors, and Clinical Management
Authors: Agüera-Ortiz Luis , García-Ramos Rocío , Grandas Pérez Francisco J. , López-Álvarez Jorge , Montes Rodríguez José Manuel , Olazarán Rodríguez F. Javier , Olivera Pueyo Javier , Pelegrin Valero Carmelo , Porta-Etessam Jesús 
Published: February 2021

Background: Alzheimer's disease (AD) and other forms of dementia are among the most common causes of disability in the elderly. Dementia is often accompanied by depression, but specific diagnostic criteria and treatment approaches are still lacking. This study aimed to gather expert opinions on dementia and depressed patient management to reduce heterogeneity in everyday practice.Methods: Prospective, multicenter, 2-round Modified Delphi survey with 53 questions regarding risk factors (11), signs and symptoms (7), diagnosis (8), and treatment (27) of depression in dementia, with a particular focus on AD. The questionnaire was completed by a panel of 37 expert physicians in neurodegenerative diseases (19 neurologists, 17 psychiatrists, and 1 geriatrician).Results: Consensus was achieved in 40 (75.5%) of the items: agreement in 33 (62.3%) and disagreement in 7 (13.2%) of them. Among the most relevant findings, depression in the elderly was considered an early sign (prodromal) and/or a dementia risk factor, so routine cognitive check-ups in depressed patients should be adopted, aided by clinical scales and information from relatives. Careful interpretation of neuropsychological assessment must be carried out in patients with depression as it can undermine cognitive outcomes. As agreed, depression in early AD is characterized by somatic symptoms and can be differentiated from apathy by the presence of sadness, depressive thoughts and early-morning awakening. In later-phases, symptoms of depression would include sleep-wake cycle reversal, aggressive behavior, and agitation. Regardless of the stage of dementia, depression would accelerate its course, whereas antidepressants would have the opposite effect. Those that improve cognitive function and/or have a dual or multimodal mode of action were preferred: Duloxetine, venlafaxine/desvenlafaxine, vortioxetine, tianeptine, and mirtazapine. Although antidepressants may be less effective than in cognitively healthy patients, neither dosage nor treatment duration should differ. Anti-dementia cholinesterase inhibitors may have a synergistic effect with antidepressants. Exercise and psychological interventions should not be applied alone before any pharmacological treatment, yet they do play a part in improving depressive symptoms in demented patients.Conclusions: This study sheds light on several unresolved clinical challenges regarding depression in dementia patients. Further studies and specific recommendations for this comorbid patient population are still needed.
SCG3 Protein Expression in Glioma Associates With less Malignancy and Favorable Clinical Outcomes
Authors: Wang Yi , Ji Nan , Wang Junmei , Cao Jingli , Li Deling , Zhang Yang , Zhang Liwei 
Published: February 2021

Introduction: Secretogranin III (SCG3) physiologically participates in neurotransmitter storage/transport and is widely expressed in neuroendocrine tumors. However, there is no report on SCG3 protein expression in gliomas.Methods: The method of immunohistochemical staining on a glioma tissue microarray was utilized to detect SCG3 protein expression and investigate the correlations of its expression with clinicopathological and genetic features in gliomas. The RNA-seq data of SCG3 in The Cancer Genome Atlas database was exploited to explore these correlations at the transcriptional level.Results: There were 57.5% (130/226) glioma cases having SCG3 cytoplasmic staining in the tissue microarray. SCG3 expression inversely correlated with malignancy grade at both transcriptional and protein levels. The highest level was observed in oligodendroglial tumors, especially in oligodendrogliomas (ODs) with IDH-mutation/1p19q-codeletion. The lowest SCG3 expression was observed in glioblastomas (GBMs), especially in the mesenchymal subtype. Nearly a half of GBM cases (44.4%, 64/144) had any discernible SCG3 staining, and were defined as SCG3-positive by the microarray study. SCG3-positive GBM cases exhibited improved overall survival as compared with the SCG3-negative cases (29.3 vs. 14.5 months; Hazard ratio, 0.364; 95% CI, 0.216–0.612; p &lt; 0.001). A multivariate Cox regression analysis also revealed SCG3 positivity as an independent favorable prognosticator in GBM patients.Conclusion: SCG3 protein expression inversely correlates with glioma malignancy and predicts favorable outcomes in GBM patients.
Polypropylene/Ethylene—And Polar—Monomer-Based Copolymers/Montmorillonite Nanocomposites: Morphology, Mechanical Properties, and Oxygen Permeability
Authors: Castro-Landinez Juan Felipe , Salcedo-Galan Felipe , Medina-Perilla Jorge Alberto 
Published: February 2021

This research reports the influence of polar monomer contents in ethylene vinyl acetate copolymer (EVA) and ethylene vinyl alcohol copolymer (EVOH) on the morphology, mechanical and barrier properties of polypropylene/ethylene copolymer (PP) reinforced with organically modified montmorillonite (MMT). PP/EVA and PP/EVOH (75/25 wt %) blends were reinforced with 3 wt % MMT in an internal mixer system. Samples were compression-molded into films of 300μ μm. The structural characterization was made using X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM), the mechanical properties were obtained by tension tests and the barrier properties by oxygen transmission rate (OTR). XRD patterns showed a combination of intercalated/exfoliated morphologies for the MMT, with higher d-001 interplanar distance increments for the blends with higher content of polar functional groups. SEM and TEM micrographs complement the results of the XRD analysis and show differences in the morphologies depending on the miscibility of the polyolefin and the polar monomer copolymer. Mechanical properties and oxygen permeability of composites exhibited a higher improvement, by the addition of MMT, for higher intermolecular interactions and most miscible polymeric system of the EVA. These results show that the higher the number of interactions, given by the VA or OH polar functional groups, the morphology and the miscibility between polyolefin and copolymer imply dispersion improvements of the nanocomposites and, in consequence, a higher improvement on the mechanical and barrier properties of the composite material.
Global Sensitivity Analysis and Calibration by Differential Evolution Algorithm of HORTSYST Crop Model for Fertigation Management
Authors: Martínez-Ruiz Antonio , Ruiz-García Agustín , Prado-Hernández J. Víctor , López-Cruz Irineo L. , Valencia-Islas J. Olaf , Pineda-Pineda Joel 
Published: February 2021

Sensitivity analysis is the first step in elucidating how the uncertainties in model parameters affect the uncertainty in model outputs. Calibration of dynamic models is another issue of considerable interest, which is usually carried out by optimizing an objective function. The first aim of this research was to perform a global sensitivity analysis (GSA) with Sobol’s method for the 16 parameters of the new HORTSYST nonlinear model that simulates photo–thermal time (PTI), daily dry matter production (DMP), nitrogen uptake (Nup), leaf area index (LAI), and crop transpiration (ETc). The second objective was to carry out the calibration of the HORTSYST model by applying a differential evolution (DE) algorithm as the global optimization method. Two tomato (Solanum lycopersicum L.) crops were established during the autumn–winter and spring–summer seasons under greenhouse and soilless culture conditions. Plants were distributed with a density of 3.5 plants m−2. Air temperature and relative humidity were measured with an S-THB-M008 model sensor. Global solar radiation was measured with an S-LIB-M003 sensor connected to a U-30-NRC datalogger. In the sensitivity analysis run in the two growth stages, it was observed that a greater number of parameters were more important at the beginning of fructification than at the end of crop growth for 10% and 20% of the variation of the parameters. The sensitivity analysis came up with nine parameters (RUE, a, b, c1 , c2, A, Bd, Bn, and PTIini) as the most important of the HORTSYST model, which were included in the calibration process with the DE algorithm. The best fit, according to RMSE, was for LAI, followed by Nup, DMP, and ETc for both crop seasons; the RMSE was close to zero, indicating a good prediction of the model’s performance.
Faktor Dominan yang Mempengaruhi Pelaksanaan Manajemen Terpadu Balita Sakit (MTBS) Di Seluruh Puskesmas Kota Tasikmalaya Jawa Barat
Authors: Setiawan Asep , Budiman Budiman , Chatarina Chatarina 
Published: February 2021

ABSTRAK
Menurut WHO dan UNICEF terdapat beberapa indikator pelaksanaan MTBS, antara lain indikator keterampilan petugas, dukungan manajemen, dan indikator tingkat kepuasan pengantar terhadap pelayanan yang diberikan. Dalam pelaksanaan MTBS di Puskesmas Kota Tasikmalaya ada yang belum mencapai target dalam penanganan balita sakit. Tujuan penelitian ini bertujuan Mengetahui faktor dominan yang mempengaruhi pelaksanaan MTBS di seluruh Puskesmas Kota Tasikmalaya.Penelitian ini merupakan jenis penelitian survey analitik dengan desain penelitian cross sectional. Sampel dalam penelitian ini adalah seluruh petugas pelaksanan MTBS yang berjumlah 106. Instrument yang digunakan dalam penelitian ini adalah kuesioner dan lembar observasi. Analisa data yang digunakan adalah Regresi Linier Sederhana untuk bivariat dan Analisis Faktor untuk multivariate.Hasil penelitian ada tiga faktor yaitu Faktor 1 (Kepemimpinan dan Kemampuan Petugas Kesehatan) terdiri dari pengetahuan, dukungan pimpinan, supervise, kelengkapan pengisian formulir. Faktor 2 (Internal petugas kesehatan dan Pendukung) terdiri dari sikap, motivasi, kelengkapan obat. Faktor 3 (Sarana dan Prasarana) terdiri dari keberadaan poli dan kelengkapan alat. Faktor dominan yang mempengaruhi pelaksanaan MTBS yaitu supervise, sikap petugas kesehatan, kelengkapan alat untuk pelaksanaan MTBS. Berdasarkan hasil penelitian direkomendasikan bahwa untuk bisa berjalannya MTBS di puskesmas perlu untuk lebih di tingkatkan supervisi fasilitatif oleh dinas kesehatan dan pimpinan puskesmas, melakukan refresing peningkatan kepatuhan atau sikap dari pelaksana MTBS dan membuat anggaran khusus untuk melengkapi peralatan MTBS.
METODE PENINGKATKAN SELF MANAGEMENT PASIEN DIABETES MELLITUS: SYSTEMATIC REVIEW
Authors: Budiawan Heri 
Published: February 2021

Pendahuluan : Penerapan program self-management perlu penyesuaian dengan berbagai aspek termasuk aspek sistem, biaya, efektifitas, hambatan dan dukungan dari pihak-pihak terkait. Oleh karena itu, review mengenai efektifitas self management pada pasien diabetes mellitus sangat diperlukan sebagai landasan dalam pengembangan metode peningkatan program self management sesuai dengan kebutuhan masing-masing penderita penyakit diabetes mellitus. Objektif : Study yang dilakukan bertujuan untuk melakukan systematic review mengenai metode yang dapat meningkatkan self management pada pasien diabetes mellitus. Metode : Metode yang digunakan dalam penelusura sumber data pada systematic literature review ini yaitu dengan penulusuran database terdiri dari Google Scholar, Pubmed, Ebsco. Artikel diseleksi berdasarkan kriteria inklusi dan melakukan critical apraisel pada setiap artikel. Hasil : Berdasarkan hasil pencarian ditetapkan 10 artikel dengan design Kuantitatif Randomize Control Trial publikasi 10 tahun terakhir (2009-2019) mengenai artikel yang berhubungan dengan peningkatan self management pada pasien dengan diabetes mellitus. Kesimpulan : Metode peningkatan self management pasien diabetes mellitus diantaranya Kunjungan kelompok dan bimbingan kelompok berbasis komunitas, peer coaching dan peer leader, motivasi, dukungan berbasis teknologi.
Pressure dependence of Poisson’s ratio of glassy Baltic amber studied by Brillouin scattering spectroscopy
Authors: Tkachev Sergey N. , Ahart Muhtar , Novikov Vladimir N. , Kojima Seiji 
Published: February 2021

Abstract
Amber is a typical natural glass with very long aging time. Elastic properties of amber at high pressures have been studied using Brillouin scattering and a diamond anvil cell. Both longitudinal and transverse acoustic modes have been observed up to 12 GPa. The pressure dependences of longitudinal, shear, Young’s, and bulk moduli, compressibility, and Poisson’s ratio were determined. The longitudinal, shear, Young’s, bulk moduli show the remarkable increase, and compressibility shows a marked decrease with increasing pressure. However, it is found that the pressure dependence of Poisson’s ratio is very small. The mechanism of this small pressure dependence was discussed. The Cauchy type relation between longitudinal and shear moduli was examined. Its coefficients show the deviation from the Cauchy relation owing to the coexistence of different intermolecular interactions in amber.
Using Text Mining and Data Mining Techniques for Applied Learning Assessment
Authors: Cook Jessica , Chen Cuixian , Griffin Angelia 
Published: February 2021

In a society where first hand work experience is greatly valued many universities or institutions of higher education have designed their Quality enhancement plan (QEP) to address student applied learning. This paper is the results of a university’s QEP plan, called Experiencing Transformative Education Through Applied Learning or ETEAL. This paper will highlight the research that was conducted using text mining and data mining techniques to analyze a dataset of 672 student evaluations collected from 40 different applied learning courses from fall 2013 to spring 2015, in order to evaluate the impact on instructional practice and student learning. Text mining techniques are applied through the NVivo text mining software to find the 100 most frequent terms to create a document-term matrix in Excel. Then, the document-term matrix is merged with the manual interpretation scores received to create the applied learning assessment data. Lastly, data mining techniques are applied to evaluate the performance, including Random Forest, K-nearest neighbors, Support Vector Machines (with linear and radial kernel), and 5-fold cross-validation. Our results show that the proposed text mining and data mining approach can provide prediction rates of around 67% to 85%, while the decision fusion approach can provide an improvement of 69% to 86%. Our study demonstrates that automatic quantitative analysis of student evaluations can be an effective approach to applied learning assessment.