bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of 18F-FDG PET/CT for predicting axillary pathologic complete response following neoadjuvant systemic therapy in breast cancer patients: emphasis on breast cancer subtype
Authors: de Mooij Cornelis M. , Mitea Cristina , Mottaghy Felix M. , Smidt Marjolein L. , van Nijnatten Thiemo J. A. 
Published: November 2021

Abstract
Background
Neoadjuvant systemic therapy (NST) is a widely accepted initial treatment modality that can lead to pathologic downstaging of the axillary disease burden in breast cancer patients. Axillary response as well as baseline 18F-fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography with computed tomography (PET/CT) differ between breast cancer subtypes. The value of baseline 18F-FDG PET/CT in predicting axillary response to NST is not yet established, possibly since breast cancer subtype was not taken into account. The purpose of this study was to investigate the value of baseline 18F-FDG PET/CT in predicting axillary response to NST with a specific emphasis on subtype.

Methods
PET-parameters derived from the primary tumor as well as the most FDG-avid axillary lymph node were measured on baseline 18F-FDG PET/CT. Overall imaging findings were compared with the gold standard of histopathology of the axillary surgery specimen. Analyses for ER-positive/HER2-negative were performed separately from HER2-positive and TN patients. In addition, separate analyses for clinically node-positive patients were performed.

Results
Sixty-six patients with 69 primary tumors were included in this study. Thirty-three axillae contained ER-positive/HER2-negative, 16 HER2-positive, and 20 TN breast cancer. No significant difference in PET-parameters between patients with axillary residual disease and axillary pathologic complete response were found for ER-positive/HER2-negative breast cancer. In the combined HER2-positive/TN subgroup, the SUVmax was significantly lower in patients without residual axillary disease in both the entire cohort and in patients with clinically node-positive disease. In this combined subgroup, a cut-off of 4.89 SUVmax measured on the most FDG-avid axillary lymph node could predict residual axillary disease with a sensitivity, specificity, PPV, and NPV of 90%, 69%, 53%, and 95%, respectively.

Conclusions
Predicting axillary response following NST with baseline 18F-FDG PET/CT can be performed when focusing on breast cancer subtypes. The easily computed PET-parameter SUVmax can predict axillary response in HER2-positive and TN breast cancer. This study adds to the accumulating evidence that studies investigating the value of 18F-FDG PET/CT in breast cancer should always take subtypes into account.
Common fixed point theorems for auxiliary functions with applications in fractional differential equation
Authors: Wongsaijai Ben , Charoensawan Phakdi , Suebcharoen Teeranush , Atiponrat Watchareepan 
Published: November 2021

AbstractIn this work, we investigate h-ϕ contraction mappings with two metrics endowed with a directed graph which involve auxiliary functions. The achievement allows us to obtain applications for the existence of the solutions for Caputo fractional boundary value problems with the integral boundary condition type. In addition, we also give examples and numerical experiments supporting our main results.
Fourth derivative singularly P-stable method for the numerical solution of the Schrödinger equation
Authors: Shokri Ali , Ramos Higinio , Mehdizadeh Khalsaraei Mohammad , Aliev Fikret A. , Bohner Martin 
Published: November 2021

AbstractIn this paper, we construct a method with eight steps that belongs to the family of Obrechkoff methods. Due to the explicit nature of the new method, not only does it not require another method as predictor, but it can also be considered as a suitable predictive technique to be used with implicit methods. Periodicity and error terms are studied when applied to solve the radial Schrödinger equation, considering different energy levels. We show its advantages in terms of accuracy, consistency, and convergence in comparison with other methods of the same order appearing in the literature.
Poly-central factorial sequences and poly-central-Bell polynomials
Authors: Kim Hye Kyung , Kim Taekyun 
Published: November 2021

AbstractIn this paper, we introduce poly-central factorial sequences and poly-central Bell polynomials arising from the polyexponential functions, reducing them to central factorials and central Bell polynomials of the second kind respectively when $k = 1$
k
=
1
. We also show some relations: between poly-central factorial sequences and power of x; between poly-central Bell polynomials and power of x; between poly-central Bell polynomials and the poly-Bell polynomials; between poly-central Bell polynomials and higher order type 2 Bernoulli polynomials of second kind; recurrence formula of poly-central Bell polynomials.
Framed slant helices in Euclidean 3-space
Authors: Okuyucu Osman Zeki , Canbirdi Mevlüt 
Published: November 2021

AbstractIn this paper, we define framed slant helices and give a necessary and sufficient condition for them in three-dimensional Euclidean space. Then, we introduce the spherical images of a framed curve. Also, we examine the relations between a framed slant helix and its spherical images. Moreover, we give an example of a framed slant helix and its spherical images with figures.
Bullying in schools: prevalence, bystanders’ reaction and associations with sex and relationships
Authors: Eijigu Temesgen Demissie , Teketel Seleshi Zeleke 
Published: November 2021

Abstract
Background
Bullying and peer victimization are the most pressing social problems affecting the wellbeing of children and adolescents. This study attempts to estimate the prevalence and examine the association of bystander’s sex, her/his relationship with the victim and with the bully, and bystander’s reaction to school bullying in East Gojjam Administrative Zone, Ethiopia.

Methods
This study followed an explanatory mixed-method study design. For the quantitative phase, 612 participants were selected using multistage cluster sampling techniques and for qualitative phase, 18 participants were selected using purposive sampling technique. We used self-reported questionnaires and semi-structured interviews to collect data from students attending grades 7, 8, 9, and 10.

Results
This study revealed that 55% of bystanders remained passive while 38% of them defended the victim upon witnessing bullying incidents. Pearson Chi-Square test for independence indicated a significant association between bystanders’ relationship with the victim and/or bully, and bystanders’ reaction. In contrast, sex has no significant association with bystanders’ reaction. The semi-structured interview data also suggested that large number of bystanders most often stood by passively while some of them defended the victim.

Conclusion
The practice of defending among students attending their education in governmental primary and secondary schools in East Gojjam Administrative Zone was low. Close social relationships (being close friends, relatives, and classmates) with the victim and bully were significantly associated with the practice of defending.
Expert consensus on drug treatment of chronic subdural hematoma
Authors: Zhang Jianning ,   Chinese Society of Neurosurgery, Chinese Medical Association, Chinese Neurosurgical Critical Care Specialist Council, Collaborational Group of Chinese Neurosurgical Translational and Evidence-based Medicine, Fei Zhou , Feng Hua , Gao Guodong , Hao Jiehe , Hou Lijun , Hu Jin , Huang Ying , Jiao Baohua , Ji Hongming , Jiang Xiaochun , Kang Dezhi , Li Jianrong , Li Xingang , Liu Jinfang , Liu Ning , Liu Xianzhi , Mao Ying , Qu Yan , Poon Wai Sang , Su Ning , Sun Tao , Sun Xiaochuan , Wang Jianjun , Wang Renzhi , Wei Junji , Wang Shuo , Yin Gangfeng , You Chao , Yu Rutong , Yu Xinguang , Yuan Xianrui , Zhang Jianmin , Zhang Junyi , Zhao Shiguang , Zhao Yuanli , Zhao Zongmao , Zhong Chunlong , Zhu Xide , Zhu Xingen , Jiang Rongcai , Wang Dong , Tian Ye , Wei Huijie , Quan Wei , Gao Chuang , Yue Shuyuan , Lei Ping , Deng Quanjun , Zhang Shu , Zhou Yuan , Sun Jian , An Shuo , Wei Yingsheng , Ge Xintong 
Published: November 2021

AbstractChronic subdural hematoma (CSDH) is a chronic space-occupying lesion formed by blood accumulation between arachnoid and dura mater, which is usually formed in the third week after traumatic brain injury. Surgical treatment is usually the first choice for patients with CSDH having a significant space-occupying effect. Most of the patients showed good results of surgical treatment, but still some patients had a postoperative recurrence (the recurrence rate was up to 33%). Because CSDH is often seen in the elderly, patients are weak and have many basic diseases. The risk of surgical treatment is high; serious complications and even death (the death rate is up to 32%) can often occur. The overall good prognosis rate of patients aged more than 90 years is 24%. The drug treatment can provide a safe and effective treatment for elderly patients who are weak, intolerable to surgery, or failed in surgery. Low-dose and long-term use of atorvastatin (20mg/d) is suggested for continuous treatment for at least 8 weeks, while low-dose and short-term use of dexamethasone can improve the therapeutic effect of atorvastatin on CSDH. Patients should undergo CT or MRI scanning at least one time within 2 weeks after the start of drug treatment.
A neoclassical perspective on Switzerland’s 1990s stagnation
Authors: Stucki Yannic , Thomet Jacqueline 
Published: November 2021

AbstractWe study Switzerland’s weak growth during the 1990s through the lens of the business cycle accounting framework of Chari et al. (Econometrica 75(3):781–836, 2007). Our main result is that weak productivity growth cannot account for the 1993–1996 stagnation episode. Rather, the stagnation is explained by factors that made labour and investment expensive. We show that increased labour income taxes and financial frictions are plausible causes. Holding these factors constant, the counterfactual annualized real output growth over the 1993Q1–1996Q4 period is 1.93% compared to realized growth of 0.35%.
Evidence of extensive cellular immune response after SARS-CoV-2 vaccination in ocrelizumab-treated patients with multiple sclerosis
Authors: Pompsch Mosche , Fisenkci Neslinur , Horn Peter A. , Kraemer Markus , Lindemann Monika 
Published: November 2021

Abstract
Background
Patients with multiple sclerosis receiving ocrelizumab-treatment are in desperate need of a protection against SARS-CoV-2 infection.

Methods
In this study, Euroimmun semi-quantitative Anti-SARS-CoV-2 IgG for detection of humoral response and ELISpot assays for detection of SARS-CoV-2-specific T-cell-response were used in 10 ocrelizumab-treated patients with multiple sclerosis twice vaccinated with Comirnaty® mRNA vaccine. This data was compared with a control group of 20 age- and sex-matched healthy volunteers, who had all previously received a full SARS-CoV-2 mRNA vaccination with Comirnaty® or Spikevax®.

Results
While all subjects in the control group had high humoral response to the vaccination, in B-cell-depleted individuals a significantly reduced antibody response to vaccination against SARS-CoV-2 was observed. SARS-CoV-2 specific T-cell-response, however, did not differ significantly between both cohorts.

Conclusions
T-cell-mediated response to Comirnaty® vaccination is observable despite attenuated humoral response in B-cell-depleted patients. This might enable partial protection against COVID-19.
Trial registration Retrospectively registered.
Frizzled3 inhibits Vangl2–Prickle3 association to establish planar cell polarity in the vertebrate neural plate
Authors: Chuykin Ilya , Itoh Keiji , Kim Kyeongmi , Sokol Sergei Y. 
Published: November 2021

ABSTRACT
The orientation of epithelial cells in the plane of the tissue, known as planar cell polarity (PCP), is regulated by interactions of asymmetrically localized PCP protein complexes. In the Xenopus neural plate, Van Gogh-like2 (Vangl2) and Prickle3 (Pk3) proteins form a complex at the anterior cell boundaries, but how this complex is regulated in vivo remains largely unknown. Here, we use proximity biotinylation and crosslinking approaches to show that Vangl2–Pk3 association is inhibited by Frizzled3 (Fz3, also known as Fzd3), a core PCP protein that is specifically expressed in the neuroectoderm and is essential for the establishment of PCP in this tissue. This inhibition required Fz3-dependent Vangl2 phosphorylaton. Consistent with our observations, the complex of Pk3 with nonphosphorylatable Vangl2 did not polarize in the neural plate. These findings provide evidence for in vivo regulation of Vangl2–Pk3 complex formation and localization by a Frizzled receptor.
Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis
Authors: Pollak Nadine , Lindner Aline , Imig Dirke , Kuritz Karsten , Fritze Jacques S. , Decker Lorena , Heinrich Isabel , Stadager Jannis , Eisler Stephan , Stöhr Daniela , Allgöwer Frank , Scheurich Peter , Rehm Markus 
Published: November 2021

ABSTRACT
Extrinsic apoptosis relies on TNF-family receptor activation by immune cells or receptor-activating drugs. Here, we monitored cell cycle progression at a resolution of minutes to relate apoptosis kinetics and cell-to-cell heterogeneities in death decisions to cell cycle phases. Interestingly, we found that cells in S phase delay TRAIL receptor-induced death in favour of mitosis, thereby passing on an apoptosis-primed state to their offspring. This translates into two distinct fates, apoptosis execution post mitosis or cell survival from inefficient apoptosis. Transmitotic resistance is linked to Mcl-1 upregulation and its increased accumulation at mitochondria from mid-S phase onwards, which allows cells to pass through mitosis with activated caspase-8, and with cells escaping apoptosis after mitosis sustaining sublethal DNA damage. Antagonizing Mcl-1 suppresses cell cycle-dependent delays in apoptosis, prevents apoptosis-resistant progression through mitosis and averts unwanted survival after apoptosis induction. Cell cycle progression therefore modulates signal transduction during extrinsic apoptosis, with Mcl-1 governing decision making between death, proliferation and survival. Cell cycle progression thus is a crucial process from which cell-to-cell heterogeneities in fates and treatment outcomes emerge in isogenic cell populations during extrinsic apoptosis.
This article has an associated First Person interview with the first author of the paper.
Diagnostic yield of CT-guided lung biopsies: how can we limit negative sampling?
Authors: Tipaldi Marcello Andrea , Ronconi Edoardo , Krokidis Miltiadis E , Zolovkins Aleksejs , Orgera Gianluigi , Laurino Florindo , Daffina Julia , Caruso Damiano , Laghi Andrea , Rossi Michele 
Published: November 2021

Objectives:
To investigate whether lesion imaging features may condition the outcome of CT-guided lung biopsy (CTLB) and to develop a scoring system of biopsy outcome prediction.

Methods:
This is a single center retrospective study on 319 CTLBs that were performed in 319 patients (167 males/152 females, mean age 68 ± 12.2). Uni- and multivariate analysis were performed aiming to assess the imaging features that are likely to be correlated to a negative biopsy outcome and patients were stratified in groups accordingly.

Results:
Technical success was 100%. 78% of the biopsies (250/319) led to a concrete histology report (218 malignant/32 benign). The remaining lesions led to concrete histology at a second attempt that occurred on a later time. Multivariate analysis revealed increased risk of inconclusive result for nodules with low fludeoxyglucose uptake [odds ration (OR) = 2.64, 95% confidence interval (CI) 1.4–4.97; p = 0.003], for nodules with diameter smaller than 18 mm (OR = 2.03, 95% CI 1.14–3.62; p = 0.017) and for nodules that are located in one of the lung bases (OR = 1.96, 95% CI 1.06–3.62; p = 0.033). Three different groups of patients were identified accordingly with low (&lt;30%), medium (30–50%) and high (&gt;50%) probability of obtaining an inconclusive biopsy sample.

Conclusion:
This study confirms that percutaneous CT-guided biopsy in nodules that are either small in diameter or present low positron emission tomography-fludeoxyglucose uptake or are in one of the lung bases may lead to inconclusive histology. This information should be factored when planning percutaneous biopsies of such nodules in terms of patient informed consent and biopsy strategy.

Advances in knowledge:
Inconclusive histology after lung biopsy may be subject to factors irrelevant to technical success. Lung biopsy histology outcomes may be predicted and avoided after adequate planning.
Postgraduate education in healthy and active ageing: learning needs, curriculum and expected outcomes: a scoping review protocol
Authors: Wiggin Daisy , Penič Benjamin , Sulopuisto Outi , Setti Annalisa , Mali Jana , Stitzel Andrea , Kuisma Raija , Baptista Fátima , Kukkonen Tuula , Konstantakopolou Olympia , Timonen Liisa , Carnide Filomena , Velanoki Venetia-Sofia , Ströckl Daniela Elisabeth , Zymbal Vera , Cardadeiro Graça , Nevala Elina , Kaitelidou Daphne , Sourtzi Panayota , Hlebec Valentina , Filipovič Hrast Maša , Timmons Suzanne 
Published: November 2021

Background: As the European population ages, it becomes increasingly important to promote and facilitate healthy and active ageing and age-friendly societies. Professionals across a range of disciplines and sectors need knowledge and skills to support both. Objective: This scoping review aims to identify and map the literature on learning needs, learning outcomes and respective curricula in healthy and active ageing and age-friendly society concepts. Inclusion criteria: Studies focused on the teaching/learning process in healthy and active ageing and/or age-friendly society, of any design type, are eligible. Included studies may focus on undergraduate, postgraduate or continuing education and on any aspect of the educational process, such as needs analysis, content delivery, learner satisfaction/acceptability, or education outcome. Methods: This review will follow the Joanna Briggs Institute (JBI) methodology for conducting scoping reviews. Four electronic databases, PubMed, EBSCO (Academic Search Complete), Scopus and Applied Social Sciences Index and Abstracts (ASSIA), will be searched, limited to studies published from 1st January 2000. Text language will be limited to English, German, Greek, Portuguese, Finnish, and Slovenian. Google Scholar and Research Gate will be searched for grey literature, limited to the first 50 results of each. Title and abstract screening, followed by full-text screening will be undertaken independently by at least two reviewers. The JBI extraction tool will be adapted for data extraction. Quality assessment will be conducted using a tool developed by Hawker and colleagues. A narrative synthesis will outline the data in relation to the aims and objectives outlined.
Znaczenie uwarunkowań socjo-demograficznych oraz wybranych cech osobowości w kształtowaniu postaw Polaków wobec szczepień przeciw COVID-19.
Authors: Paduch Jarosław , Syrowatko Agnieszka , Żołnierczuk Michał 
Published: November 2021

Cel pracy: Celem pracy jest określenie poziomu poszczególnych cech osobowości oraz postaw Polaków wobec szczepień ochronnych, w tym przeciw COVID-19 oraz analiza potencjalnych predyktorów tych postaw.
Materiały i metody: Badaniem online, prowadzonym we wrześniu i październiku 2021 roku objęto 1466 osób (50,6% kobiet) w wieku od 18 do 80 lat (M = 42.81; SD = 12.46). Anonimowa i dobrowolna ankieta online zawierała autorskie pytania dotyczące postaw wobec szczepień ochronnych, w tym także szczepień przeciwko COVID-19, oceniane na skali 1-7, wystąpienie NOP w przeszłości i polską adaptację testu Ten Item Personality Inventory (TIPI)- TIPI-PL.
Wyniki: Wykazano, że istotnymi predyktorami poziomu akceptacji szczepień ochronnych były: płeć żeńska, wielkość miejsca zamieszkania, wykształcenie i wystąpienie NOP w przeszłości. W przypadku cech osobowościowych była to ugodowość, stabilność emocjonalna oraz otwartość na doświadczenie. Istotny związek miały również źródła wiedzy na temat szczepień: opinie znajomych, Internet i opinie ekspertów. Wyższy poziom ugodowość i otwartości na doświadczenie współwystępował z wyższym poziomem akcpetacji szczepień ochronnych, natomiast wyższy poziom stabilności emocjonalnej korelował z niższym poziomem akceptacji szczepień. Płeć żeńska, wyższe wykształcenie oraz wielkość miejscowości zamieszkania predysponowały do akceptacji szczepień ochronnych, natomiast wystąpienie NOP predysponowało do niskiego jej poziomu.
Comparison of the physical fitness of karate and taekwondo elite athletes
Authors: Gunawan Gunawan 
Published: November 2021

Introduction. A coach compiles and determines a training program based on the physical fitness profile of the athlete. Central Sulawesi taekwondo and karate athletes have been undergoing independent training since mid-2020.
Objective of the study. This study aims to investigate the comparison in physical fitness of elite athletes in taekwondo and karate
Research methods. This study uses a causal-comparative method, where the researcher seeks to determine the cause or effect of the differences that occur between groups. The sample of this research is 20 elite athletes. Evaluation of physical abilities or physical fitness is an instrument used to measure the physical fitness of taekwondo and karate athletes. An independent sample t-test was used for comparison of independent samples.
Research result and Conclusion. The results and conclusions of the study indicate that descriptively the speed, endurance of abdominal muscle strength, and endurance of thigh muscle strength, agility, flexibility, leg reaction speed, and cardiovascular endurance of taekwondo athletes are higher than karate athletes, while for leg muscle strength and breathing karate athletes are higher than taekwondo athletes. Sig value. (2 tailed) or p-value <0.05, it can be concluded that there is a significant difference in the variable components of physical fitness, abdominal muscle strength, agility, flexibility in leg reaction speed, and cardiovascular endurance between taekwondo athletes and karate athletes. Whereas in the variable components of physical fitness, speed, endurance, thigh muscle strength, and leg and respiratory muscle strength, there were no significant differences between taekwondo athletes and karate.