bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement invariance of the Brief Sense of Community Scale across non‐Hispanic, Black and Hispanic college students
Authors: Cardenas Iris , Steiner Jordan J. , Peterson N. Andrew 
Published: June 2021

AbstractEthnic‐racial background may influence college students' psychological sense of community (PSOC). Thus, it is critical to examine whether this construct is conceptualized similarly between non‐Hispanic, Black and Hispanic students. This study tested the measurement invariance of the Brief Sense of Community Scale (BSCS) across the two groups. We used data from a self‐administered online survey provided to college students in 2016 in a Northeastern urban university (non‐Hispanic, Black = 307; Hispanic = 409). We tested the measurement invariance of the BSCS using a series of nested multigroup confirmatory factor analyses with increasingly restrictive sets of parameters. Measurement invariance of the BSCS across non‐Hispanic, Black and Hispanic college students was achieved. The BSCS successfully measures the multidimensionality of PSOC across the two groups in a college setting. Students' score on the BSCS is not biased by measurement invariance related to cultural influences. When using the BSCS, community psychologists and researchers can have confidence that the observed differences in PSOC across non‐Hispanic, Black and Hispanic college students are attributable to true differences rather than a cultural understanding of the construct.
Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder – a longitudinal sibling control study
Authors: Gustavson Kristin , Ystrom Eivind , Ask Helga , Ask Torvik Fartein , Hornig Mady , Susser Ezra , Lipkin W. Ian , Lupattelli Angela , Stoltenberg Camilla , Magnus Per , Mjaaland Siri , Askeland Ragna Bugge , Walle Kjersti Mæhlum , Bresnahan Michaeline , Nordeng Hedvig , Reichborn‐Kjennerud Ted 
Published: June 2021

AbstractBackgroundMaternal acetaminophen use during pregnancy is associated with increased risk of ADHD in the child. This could reflect causal influence of acetaminophen on fetal neurodevelopment or could be due to confounding factors. The aim of the current study was to examine unmeasured familial confounding factors of this association.MethodsWe used data from 26,613 children from 12,902 families participating in the prospective Norwegian Mother, Father, and Child Cohort Study (MoBa). The MoBa was linked to the Norwegian Medical Birth Register and the Norwegian Patient Registry. Siblings discordant for prenatal acetaminophen exposure were compared regarding risk of having an ADHD diagnosis.ResultsChildren exposed to acetaminophen up to 28 days during pregnancy did not have increased risk of receiving an ADHD diagnosis compared to unexposed children. The adjusted Hazard ratio (aHR) was 0.87 (95% C.I. = 0.70‐1.08) for exposure 1 to 7 days, and 1.13 (95% C.I. = 0.82–1.49) for 8–28 days. Long‐term exposure (29 days or more) was associated with a two‐fold increase in risk of ADHD diagnosis (aHR = 2.02, 95% C.I = 1.17–3.25). In the sibling control model, the association between long‐term acetaminophen use and ADHD in the child was aHR = 2.77 (95% C.I. = 1.48–5.05) at the between‐family level, and aHR = 1.06 (95% C.I. = 0.51–2.05) at the within‐family level.ConclusionsBoth the exposed and the unexposed children of mothers with long‐term use of acetaminophen in one of the pregnancies had increased risk of receiving an ADHD diagnosis. This indicates that the observed association between long‐term acetaminophen use during pregnancy and ADHD in the child may at least partly be confounded by unobserved family factors.
High powers of Hamiltonian cycles in randomly augmented graphs
Authors: Antoniuk Sylwia , Dudek Andrzej , Reiher Christian , Ruciński Andrzej , Schacht Mathias 
Published: June 2021

AbstractWe investigate the existence of powers of Hamiltonian cycles in graphs with large minimum degree to which some additional edges have been added in a random manner. For all integers , and , and for any we show that adding random edges to an ‐vertex graph with minimum degree at least yields, with probability close to one, the existence of the ‐th power of a Hamiltonian cycle. In particular, for and this implies that adding random edges to such a graph already ensures the ‐st power of a Hamiltonian cycle (proved independently by Nenadov and Trujić). In this instance and for several other choices of , and we can show that our result is asymptotically optimal.
Psychosocial factors 3‐months after anterior cruciate ligament reconstruction predict 6‐month subjective and objective knee outcomes
Authors: Erickson Lauren N. , Jacobs Cale A. , Johnson Darren L. , Ireland Mary L. , Noehren Brian 
Published: June 2021

AbstractThe objective of the study was to determine if psychological readiness for sport and knee self‐efficacy assessed early (3 months) after anterior cruciate ligament reconstruction (ACLR) are predictive of self‐reported functional outcomes, quadriceps strength, and knee mechanics while running at the time of return to sport training (6 months). Thirty athletes with unilateral ACLR completed the ACL Return to Sport after Injury (ACL‐RSI) and Knee Self‐Efficacy Scale (K‐SES) 3 months after ACLR and completed self‐reported functional outcomes, isometric quadriceps strength testing, and three‐dimensional running gait analysis 6 months after ACLR. The 3‐month ACL‐RSI significantly correlated with the 6‐month International Knee Documentation Committee (IKDC; r = 0.565, p = 0.001), Knee Injury and Osteoarthritis Outcome Score (KOOS) sport/recreational activities (KOOSSport; r = 0.548, p = 0.002) and quality of life (KOOSQoL; r = 0.431, p = 0.017), and quadriceps strength (r = 0.528, p = 0.003). The 3‐month K‐SES significantly correlated with the 6‐month IKDC (r = 0.528, p = 0.003), KOOSSport (r = 0.430, p = 0.018), KOOSQoL (r = 0.411, p = 0.024), quadriceps strength (r = 0.465, p = 0.010), and knee flexion excursion (r = 0.472, p = 0.008). With multivariate modeling, both the ACL‐RSI and K‐SES were predictive of the IKDC (R2 = 0.411; p = 0.001). Only the ACL‐RSI was predictive of the KOOSSport (R2 = 0.300; p = 0.002), KOOSQoL (R2 = 0.186; p = 0.017), and quadriceps strength (R2 = 0.279; p = 0.003), whereas only the K‐SES was predictive of knee flexion excursion (R2 = 0.173; p = 0.022). Athletes with greater psychological readiness for sport and knee self‐efficacy at 3 months demonstrated higher scores on self‐reported functional outcomes, greater quadriceps strength, and greater knee flexion excursion at 6 months after ACLR. This study indicates that psychosocial measures may be important to include into early post‐surgical evaluations to help guide and facilitate interventions to restore subjective and objective knee function.
Lesser Prairie‐Chicken Survival in Varying Densities of Energy Development
Authors: LAWRENCE Andrew J. , Carleton Scott A. , Gould William R. , Nichols Clay T. 
Published: June 2021

ABSTRACTAnthropogenic features increasingly affect ecological processes with increasing human demand for natural resources. Such effects also have the potential to vary depending on the sex and age of an individual because of inherent behavioral and life experience differences. For the lesser prairie‐chicken (Tympanuchus pallidicinctus), studies on male survival are limited because most previous research has been focused on females. To better understand patterns of lesser prairie‐chicken survival in habitat with varying levels of anthropogenic infrastructure associated with oil and natural gas development, we monitored survival of 178 radio‐tagged male and female lesser prairie‐chickens in eastern New Mexico, USA, from 2013 to 2015. We examined the relationships of shrub cover, proximity to and density of anthropogenic features (i.e., utility poles), displacement of natural vegetation by anthropogenic features (i.e., area of roads and well pads), and individual demographics (i.e., sex, age) with lesser prairie‐chicken survival. Furthermore, we categorized the probable cause of mortality and examined its relationship with oil and gas development intensity (indexed by utility pole density) within 1,425 m of an individual's mortality site or final observed location. We predicted that survival would be lower for individuals exposed to greater levels of anthropogenic features, and that males and subadults would be more negatively affected than females and adults because of increased exposure to predators during the lekking season and naiveté. Relationships between survival and utility pole density, sex, and age were supported in our top‐ranked models, whereas models including other anthropogenic and natural features (i.e., roads, well pads, shrub cover) received little support. We predicted a substantial decrease in adult and subadult male survival with increasing densities of utility poles. The relationship between survival and utility pole density for females was weaker and not as clearly supported as for males. We did not find a detectable difference in utility pole counts among probable mortality causes. Our findings highlight the importance of including male lesser prairie‐chickens in research and conservation planning, and the negative effect that high densities of anthropogenic features can have on lesser prairie‐chicken survival. © 2021 The Wildlife Society.
Closure of a free osteofasciocutaneous fibula flap donor site using local skin grafts or flaps: A systematic review and meta‐analysis
Authors: Shimbo Keisuke , Okuhara Yukako , Yokota Kazunori 
Published: June 2021

AbstractBackgroundIn free osteofasciocutaneous fibula flaps, secondary donor sites are avoided using one of three local closure methods: full‐thickness skin grafts (FTSGs), split‐thickness skin grafts (STSGs), or flaps. This systemic review aimed to evaluate the differences in outcomes among the three groups of closure methods used for free fibula flap defects.MethodsIn accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) guidelines, we systematically searched the PubMed and Web of Science medical databases from inception to January 2021 for articles focused on closure of the free fibula flap donor site using the lower leg area—local skin graft or flap—that mentioned the free fibula flap defect size, and/or complications of the donor site. Study characteristics, free fibula flap size, and short‐term complication rates were extracted for analysis. The pooled complication rates and confidence intervals were calculated based on the random‐effects model.ResultsEleven studies were included in the qualitative synthesis, and ten studies were included in the quantitative synthesis (meta‐analysis). The FTSG (n = 79, 52.3%) was the most widely used method, while both STSG (n = 36, 23.8%) and flap (n = 36, 23.8%) were the least commonly used methods. The mean free fibula flap length and width were largest for the flap method (11.5 ± 2.5 cm and 6.0 ± 1.8 cm), and all closure methods were used for free fibula flap widths ≥3 cm. Rates of partial and complete necrosis were highest for the FTSG method (20.3%, p = .95, I2 = 0%) and lowest for the flap method (12.7%, p = .95, I2 = 0%).ConclusionThis systemic review indicated that any closure method could be adapted for a free fibula flap width ranging from 3 to 9 cm, and the flap method was associated with the lowest rate of short‐term complications.
OpenKBP: The open‐access knowledge‐based planning grand challenge and dataset
Authors: Babier Aaron , Zhang Binghao , Mahmood Rafid , Moore Kevin L. , Purdie Thomas G. , McNiven Andrea L. , Chan Timothy C. Y. 
Published: June 2021

PurposeTo advance fair and consistent comparisons of dose prediction methods for knowledge‐based planning (KBP) in radiation therapy research.MethodsWe hosted OpenKBP, a 2020 AAPM Grand Challenge, and challenged participants to develop the best method for predicting the dose of contoured computed tomography (CT) images. The models were evaluated according to two separate scores: (a) dose score, which evaluates the full three‐dimensional (3D) dose distributions, and (b) dose‐volume histogram (DVH) score, which evaluates a set DVH metrics. We used these scores to quantify the quality of the models based on their out‐of‐sample predictions. To develop and test their models, participants were given the data of 340 patients who were treated for head‐and‐neck cancer with radiation therapy. The data were partitioned into training (), validation (), and testing () datasets. All participants performed training and validation with the corresponding datasets during the first (validation) phase of the Challenge. In the second (testing) phase, the participants used their model on the testing data to quantify the out‐of‐sample performance, which was hidden from participants and used to determine the final competition ranking. Participants also responded to a survey to summarize their models.ResultsThe Challenge attracted 195 participants from 28 countries, and 73 of those participants formed 44 teams in the validation phase, which received a total of 1750 submissions. The testing phase garnered submissions from 28 of those teams, which represents 28 unique prediction methods. On average, over the course of the validation phase, participants improved the dose and DVH scores of their models by a factor of 2.7 and 5.7, respectively. In the testing phase one model achieved the best dose score (2.429) and DVH score (1.478), which were both significantly better than the dose score (2.564) and the DVH score (1.529) that was achieved by the runner‐up models. Lastly, many of the top performing teams reported that they used generalizable techniques (e.g., ensembles) to achieve higher performance than their competition.ConclusionOpenKBP is the first competition for knowledge‐based planning research. The Challenge helped launch the first platform that enables researchers to compare KBP prediction methods fairly and consistently using a large open‐source dataset and standardized metrics. OpenKBP has also democratized KBP research by making it accessible to everyone, which should help accelerate the progress of KBP research. The OpenKBP datasets are available publicly to help benchmark future KBP research.
Neurocognitive Impairment After Hematopoietic Stem Cell Transplant for Hematologic Malignancies: Phenotype and Mechanisms
Authors: Harrison Rebecca A. , Sharafeldin Noha , Rexer Jennie L. , Streck Brennan , Petersen Melissa , Henneghan Ashley M. , Kesler Shelli R. 
Published: June 2021

AbstractHematopoietic stem cell transplant (HSCT) plays a central role in the treatment of hematologic cancers. With the increasing survival of patients after HSCT, survivorship issues experienced by this population have become an important outcome. Cognitive impairment is an established sequela of HSCT, with studies to date establishing its presence, associated risk factors, and clinical phenotype. There are multiple potential contributors to cognitive impairment after HSCT. Efforts are ongoing to further characterize its clinical phenotype, associated biomarkers, and biologic underpinnings. A fundamental knowledge of post-HSCT cognitive impairment is of value for all clinicians who interface with this population, and further academic efforts are needed to more fully understand the impact of this cancer treatment on brain health.Implications for PracticeAs survival outcomes after hematopoietic stem cell transplant (HSCT) improve, an awareness of the post-treatment challenges faced by this population has become central to its care. HSCT can have a sustained and broad impact on brain health, causing cognitive dysfunction, fatigue, disturbed mood, and sleep. In affected patients, autonomy, return to work, relationships, and quality of life may all be affected. A fundamental fluency in this area is important for clinicians interfacing with HSCT survivors, facilitating the identification and management of cognitive dysfunction and concurrent symptom clusters, and stimulating interest in these sequelae as areas for future clinical research.
Ocean health in the Northeast United States from 2005 to 2017
Authors: Montgomery Jamie , Scarborough Courtney , Shumchenia Emily , Verstaen Juliette , Napoli Nick , Halpern Benjamin 
Published: June 2021

Abstract

People in the Northeast United States have a long history of benefitting from the ocean in many ways, exemplified by the region's important cod and lobster fisheries, coastal tourism and recent expansion of offshore energy. Over the past few decades, the region has become one of the fastest warming spots on the planet, has seen significant growth in coastal populations, and expansion of new sectors into the marine environment, resulting in ecosystem shifts and changes to the supply and distribution of these benefits. With these changes comes a need for measuring ocean health to understand how engagement with the ocean may be affected, and how regional management may need to adapt.

To address this need, we tailored the Ocean Health Index framework to the U.S. Northeast region, scoring eight distinct goals for ocean health on a scale of 0 to 100 for 11 sub‐regions over 13 years (2005–2017).

All goal scores were averaged resulting in an Ocean Health Index score of 83 for the Northeast in 2017. This score fluctuated by 1 point in either direction (82–84) in the previous 12 years.

The lowest scoring goals in 2017 also exhibited the highest volatility since 2005, Food Provision (64) and Resource Access Opportunities (71).

The region's highest goal scores came from Livelihoods & Economies (99) and Biodiversity (90) and remained stable during the study period.

Clean Waters scores had a steady, significant downward trend since 2005, while Resource Access Opportunities and Aquaculture show the largest improvements.

This synthesis of over 50 datasets to create annual aggregate scores provides the public, government and non‐government agencies with an easily digestible summary of how the region is faring in regards to ocean health. Perhaps even more importantly, this synthesis allows for the tracking of trends over time and the ability to quickly identify and prioritize low‐scoring components of ocean health that could benefit from dedicated resources for improvement.

As managers plan for the future in a changing Northeast marine region, the ability to track annual changes in ocean health and its respective components is key to making decisions that benefit the entire social‐ecological system.

A free Plain Language Summary can be found within the Supporting Information of this article.
Tick‐over‐mediated complement activation is sufficient to cause basal deposit formation in cell‐based models of macular degeneration
Authors: Chinchilla Blanca , Foltopoulou Parthena , Fernandez‐Godino Rosario 
Published: June 2021

AbstractDespite numerous unsuccessful clinical trials for anti‐complement drugs to treat age‐related macular degeneration (AMD), the complement system has not been fully explored as a target to stop drusen growth in patients with dry AMD. We propose that the resilient autoactivation of C3 by hydrolysis of its internal thioester (tick‐over), which cannot be prevented by existing drugs, plays a critical role in the formation of drusenoid deposits underneath the retinal pigment epithelium (RPE). We have combined gene editing tools with stem cell technology to generate cell‐based models that allow the role of the tick‐over in sub‐RPE deposit formation to be studied. The results demonstrate that structurally or genetically driven pathological events affecting the RPE and Bruch's membrane can lead to dysregulation of the tick‐over, which is sufficient to stimulate the formation of sub‐RPE deposits. This can be prevented with therapies that downregulate C3 expression. © 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Psychological problems among cancer patients in relation to healthcare and societal costs: A systematic review
Authors: Van Beek Florie E. , Wijnhoven Lonneke M. A. , Holtmaat Karen , Custers José A. E. , Prins Judith B. , Verdonck‐de Leeuw Irma M. , Jansen Femke 
Published: June 2021

AbstractObjectiveThis study systematically reviewed the association of psychological problems among cancer patients with healthcare and societal resource use and costs.MethodsPubMed, PsycINFO, and Embase were searched (until 31 January 2021) for studies on psychological symptoms (anxiety, depression, distress, fear of recurrence) or psychiatric disorders (anxiety, depression, adjustment) and healthcare use (e.g., mental, inpatient healthcare), economic losses by patients and family, economic losses in other sectors (e.g., absence from work), and costs. The search, data extraction, and quality assessment were performed by two authors.ResultsOf the 4157 identified records, 49 articles were included (psychological symptoms (n = 34), psychiatric disorders (n = 14), both (n = 1)) which focused on healthcare use (n = 36), economic losses by patients and family (n = 5), economic losses in other sectors (n = 8) and/or costs (n = 13). In total, for 12 of the 94 associations strong evidence was found. Psychological symptoms and psychiatric disorders were positively associated with increased healthcare use (mental, primary, inpatient, outpatient healthcare), losses in other sectors (absence from work), and costs (inpatient, outpatient, total healthcare costs). Moderate evidence was found for a positive association between (any) psychiatric disorder and depression disorder with inpatient healthcare and medication use, respectively.ConclusionsPsychological problems in cancer patients are associated with increased healthcare use, healthcare costs and economic losses. Further research is needed on psychological problems in relation to understudied healthcare use or costs categories, productivity losses, and informal care costs.
Long‐term course of bronchial inflammation and pulmonary function testing in children with postinfectious bronchiolitis obliterans
Authors: Jerkic Silvija P. , Koc‐Günel Sinem , Herrmann Eva , Kriszeleit Lia , Eckrich Jonas , Schubert Ralf , Zielen Stefan 
Published: June 2021

AbstractRationalePostinfectious bronchiolitis obliterans (PIBO) is a rare, chronic respiratory condition, which follows an acute insult due to a severe infection of the lower airways.ObjectivesThe objective of this study was to investigate the long‐term course of bronchial inflammation and pulmonary function testing in children with PIBO.MethodsMedical charts of 21 children with PIBO were analyzed retrospectively at the Children's University Hospital Frankfurt/Main Germany. Pulmonary function tests (PFTs) with an interval of at least 1 month were studied between 2002 and 2019. A total of 382 PFTs were analyzed retrospectively and per year, the two best PFTs, in total 217, were evaluated. Additionally, 56 sputum analysis were assessed and the sputum neutrophils were evaluated.ResultsThe evaluation of the 217 PFTs showed a decrease in FEV1 with a loss of 1.07% and a loss in z score of −0.075 per year. FEV1/FVC decreased by 1.44 per year. FVC remained stable, showing a nonsignificant increase by 0.006 in z score per year. However, FEV1 and FVC in L increased significantly with FEV1 0.032 L per cm and FVC 0.048 L/cm in height. Sputum neutrophils showed a significant increase of 2.12% per year.ConclusionOur results demonstrated that in patients with PIBO pulmonary function decreased significantly showing persistent obstruction over an average follow‐up period of 8 years. However, persistent lung growth was revealed. In addition, pulmonary inflammation persisted clearly showing an increasing amount of neutrophils in induced sputum. Patients did not present with a general susceptibility to respiratory infections.