bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Predictors of Abnormal Head Computed Tomography Findings in Non-trauma Patients Presenting to a South African Emergency Department
Authors: Simwatachela Ekin , Ozoh John O. , Mabuza Langalibalele H. , Kalinda Chester 
Published: October 2021

Background: Head computed tomography (head CT) examinations conducted at emergency departments (EDs) for non-trauma patients are expensive and expose patients to ionizing radiation. Identification of symptoms likely to yield abnormal head CT scans can reduce costs and prevent unnecessary patient irradiation. There is limited comprehensive data in the literature concerning the utilization of head CT in low- and middle-income countries (LMICs) EDs.Methods: A retrospective study of successive non-contrasted head CT scans from February 2017 through January 2018 performed on non-trauma ED patients aged 18 years and above without known pre-existing intracranial pathology was conducted. Univariate and multivariate logistic models were used to determine which presenting clinical features were likely to yield abnormal head CT findings. Clinical information was obtained from the history and physical examination findings entered on the requisition form by the ED clinicians and from previous head CT reports if present on the picture archiving and communication system (PACS).Results: A total of 396 consecutive patients who received head CT examinations had a median age of 49 years (IQR: 36–53), and 53.3% were male (n = 211/396). Of the head CT scans included, 73.5% of head CTs included were abnormal (n = 291/396). Age &gt;61 years (aOR:1.54; 95%CI: 1.12–2.10), focal neurologic deficit (aOR: 2.46; 95%CI: 1.42–4.26), and loss of consciousness (aOR 2.82; 95%CI: 1.21–6.57) were the predictors of abnormal head CT findings.Conclusion: A head CT scan in a non-trauma patient presenting to an emergency department in a low–middle income country like South Africa is likely to yield abnormal findings if a patient presented with age above 61 years, loss of consciousness, or focal neurological deficit.
Penghidupan Berkelanjutan (Sustainable Livelihood) Rukun Nelayan Tanggulangin Kecamatan Klirong Kabupaten Kebumen
Authors: Fitri Zulaikhah , Sugihardjo Sugihardjo , Wibowo Agung 
Published: October 2021

Rukun Nelayan Tanggulangin selama ini masih bergantung pada hasil tangkapan ikan padahal sumber daya yang tersedia dapat dimanfaatkan dan dikelola dengan baik untuk meningkatkan penghidupan. Pendekatan penghidupan berkelanjutan dibutuhkan guna menentukan nelayan mempertahankan hidupnya. Penelitian ini bertujuan untuk mengkaji penghidupan berkelanjutan Rukun Nelayan Tanggulangin untuk dapat bertahan hidup. Penelitian ini menggunakan metode kualitatif deskriptif dan analisis data secara interaktif dan berlangsung secara terus menerus hingga data jenuh. Hasil penelitian menunjukkan bahwa penghidupan berkelanjutan yang dilakukan oleh Rukun Nelayan Tanggulangin adalah dengan tetap mempertahankan sarana penangkapan ikan secara tradisional dan ramah lingkungan; mempertahankan modal sosial; memanfaatkan peluang mata pencaharian lain sesuai dengan sumber daya alam yang tersedia serta memberdayakan anak, saudara dan istri nelayan.Kata kunci : berkelanjutan, penghidupan, rukun nelayan
The specifics of the interaction of a civilized society with a barbaric one: internal and external aspects
Authors: Сулимов С.И. , Черниговских И.В. 
Published: October 2021

в статье рассматриваются особенности взаимодействия цивилизованного общества с его варварскими соседями. Авторы полагают, что такое общество не может стать жертвой победоносного нашествия внешних варваров до тех пор, пока само не откажется от цивилизованного образа жизни, а это возможно только под влиянием внутреннего импульса.
the article examines the features of the interaction of a civilized society with its barbaric neighbors. The authors believe that such a society cannot become a victim of the victorious invasion of external barbarians until it itself renounces the civilized way of life, and this is possible only under the influence of an internal impulse.
The concept of state policy for the formation of a harmonious educational space in the multiethnic environment of secondary schools in the Moscow region
Authors: Ершов В.Ф. 
Published: October 2021

в статье рассматривается государственная образовательная политика в сфере реализации перспективного комплекса учебно-методических, организационных и общественно-культурных мероприятий по интеграции детей-иммигрантов в российский социум. Раскрывается перспективное значение научно-исследовательской разработки вопросов интеграции детей-инофонов в российское образовательное пространство, особенностей их языковой и культурной адаптации, методики организации учебного процесса и др. Актуальность статьи определяется задачами дальнейшего строительства в России гармоничного общества, совершенствования методики преподавания, формирования толерантного образовательного пространства в школах Подмосковья. Автор приходит к выводу о том, что современная система образования России успешно решает данный вопрос, обеспечивая обучение детей-иммигрантов на необходимом уровне. В то же время существуют направления возможного дополнительного совершенствования учебно-методической и психологической работы с детьми-инофонами в целях их быстрейшей и комфортной интеграции в социум страны проживания – России. Стремление детей иммигрантов получить образование и интегрироваться в российское общество делает их креативными гражданами страны, укрепляя межцивилизационный диалог в рамках стран СНГ и всего постсоветского пространства.
the paper examines the state educational policy in the implementation of a promising complex of educational, methodological, organizational, and socio-cultural activities for the integration of immigrant children into the Russian society. The article reveals the promising significance of the research development of the issues of integrating children-speakers of other languages into the Russian educational space, the peculiarities of their linguistic and cultural adaptation, methods of organizing the educational process, etc. The relevance of the article is determined by the tasks of further building a harmonious society in Russia, improving teaching methods, forming a tolerant educational space in schools in the Moscow region. The author concludes that the modern education system in Russia successfully solves this issue, providing education for immigrant children at the required level. At the same time, there are directions for possible additional improvement of educational, methodological, and psychological work with the children-speakers of other languages to integrate them quickly and comfortably into the society of the country of residence – Russia. The desire of immigrant children to get an education and integrate into Russian society makes them creative citizens of the country, strengthening the inter-civilizational dialogue within the CIS countries and the entire post-Soviet space.
Circular RNA circSamd4a Regulates Antiviral Immunity in Teleost Fish by Upregulating STING through Sponging miR-29a-3p
Authors: Su Hui , Zheng Weiwei , Pan Jiajia , Lv Xing , Xin Shiying , Xu Tianjun 
Published: October 2021

Abstract
Circular RNAs (circRNAs) are a subgroup of endogenous noncoding RNA that is covalently closed rings and widely expressed. In recent years, there is accumulating evidence indicating that circRNAs are a class of important regulators, which play an important role in various biological processes. However, the biological functions and regulation mechanism of circRNAs in lower vertebrates are little known. In this study, we discovered a circRNA Samd4a (circSamd4a) that is related to the antiviral immune response of teleost fish. It can act as a key regulator of the host’s antiviral response and play a key role in inhibiting Sininiperca chuatsi rhabdovirus replication. Further studies have shown that circSamd4a may act as a competing endogenous RNA, which can enhance the STING-mediated NF-κB/IRF3 signaling pathway by adsorbing miR-29a-3p, thereby enhancing the antiviral immune response. Therefore, circSamd4a plays an active regulatory role in the antiviral immune response of bony fish. Our research results provide a strong foundation for circular RNA to play a regulatory role in the antiviral immune response of teleost fish.
Classificação dos fatores de risco relacionados com a produtividade da construção civil
Authors: Chaves Lárdner Gadelha , Campos Vanessa Ribeiro 
Published: October 2021

The activities that seek to improve productivity are considered one of the main concerns of construction companies. Studies on this topic provide a better understanding as well as initiatives to make processes more efficient. In this context, this paper identifies the risk factors that most affect productivity in the construction industry, and proposes a classification for them in order to identify its main sources of occurrence. A bibliographical study from periodicals and scientific events was carried out with a total of 17 papers that identified and hierarchized these factors. Thus, the risks were classified according to four categories, presented according to their order of importance: process, materials, environment and workers. Finally, some measures are indicated to mitigate or prevent the occurrence of these phenomena.
Análise do sistema de gestão da qualidade em três empresas da construção civil do Ceará
Authors: Sampaio Andressa Dyalla de Sá , Alcântara Caio Siebra , Campos Vanessa Ribeiro 
Published: October 2021

A gestão da qualidade na construção civil é primordial para as empresas que procuram diferenciais competitivos como melhorias de qualidade para atender às expectativas dos clientes. Apesar disso, a implantação de um Sistema de Gestão de Qualidade (SGQ) na construção civil possui dificuldades em assimilar as necessidades do mercado ou do cliente final. O presente trabalho tem como objetivo avaliar o SGQ de três empresas do Ceará, destacando os principais elementos formadores e suas dificuldades de manutenção. Essa análise foi feita por meio da aplicação de um questionário com 13 questões discursivas para caracterização do SGQ na estrutura das empresas da construção civil. Dessa forma, foi possível elaborar uma discussão analítica sobre a importância do Sistema de Gestão de Qualidade para as construtoras e a estrutura de implantação e manutenção do SGQ dessas empresas, destacando os elementos de inspeção, acompanhamento dos serviços e vantagens relacionadas à valorização do cliente.
Plano de execução BIM em MPE
Authors: Paiva Junior Francisco Alverne Albuquerque , Cândido Luis Felipe 
Published: October 2021

Plano de Execução BIM (PEB) é um documento para delinear a visão geral do uso do BIM, com detalhes de implementação e informações relevantes para a equipe seguir no projeto. Seu uso pode ser essencial para uma implementação bem-sucedida do BIM. Deste modo, diversos protocolos que instruem a construção de PEB foram desenvolvidos. Porém, eles não diferenciam diretrizes para as Micro e Pequenas Empresas (MPE), levando à seguinte questão: qual a percepção de gestores de MPE sobre o uso de PEB? Assim, essa pesquisa investigou a percepção de gestores de MPE da construção sobre o uso do PEB em suas empresas. Foi abordado a relevância desse plano para as empresas e sua utilização, os aspectos contratuais e o que eles consideravam relevantes em um PEB. Identificou-se que: os respondentes não haviam utilizado um PEB, mas tinham interesse em usar; a dificuldade de integrar clientes em PEB, devido sua falta de percepção sobre o BIM; e a dificuldade do uso de um contrato formal único para todos os envolvidos. Dessa forma, a pesquisa contribui com evidências sobre o uso do PEB em MPE, o que trouxe reflexões importantes para direcionar a construção de PEB nesse contexto.
Speciated atmospheric mercury at the Waliguan Global Atmosphere Watch station in the northeastern Tibetan Plateau: implication of dust-related sources for particulate bound mercury
Authors: Zhang Hui , Fu Xuewu , Yu Ben , Li Baoxin , Liu Peng , Zhang Guoqing , Zhang Leiming , Feng Xinbin 
Published: October 2021

Abstract. To understand the ambient levels and sources of atmospheric mercury (Hg) in
the Tibetan Plateau, a full-year continuous measurement of speciated
atmospheric mercury was conducted at the Waliguan (WLG) Baseline Observatory
(3816 m a.s.l.) from May 2012 to April 2013. Mean concentrations (± 1 SD) of gaseous elemental mercury (GEM), gaseous oxidized mercury (GOM) and
particulate bound mercury (PBM) during the whole study period were 1.90±0.80 ng m−3, 12.0±10.6 and 65.4±63.2 pg m−3, respectively. Seasonal variations of GEM were very small,
while those of PBM were quite large with mean values being 4 times higher
in the cold (102.3±66.7 pg m−3) than warm (22.8±14.6 pg m−3) season. Anthropogenic emissions to the east of the Tibetan Plateau
contributed significantly to GEM pollution at WLG, while dust particles
originating from desert and Gobi regions in Xinjiang province and the Tibetan
Plateau to the west of WLG were responsible for PBM pollution at WLG. This
finding is also supported by the significant positive correlation between
daily PBM concentration and daily cumulative absorbing aerosol index (AAI)
in air masses transported during the preceding 2 d.
Effects of spatial resolution of terrain models on modelled discharge and soil loss in Oaxaca, Mexico
Authors: Naranjo Sergio , Rodrigues Jr. Francelino A. , Cadisch Georg , Lopez-Ridaura Santiago , Fuentes Ponce Mariela , Marohn Carsten 
Published: October 2021

Abstract. The effect of the spatial resolution of digital terrain models (DTMs) on topography and soil erosion modelling is well documented for low resolutions. Nowadays, the availability of high spatial resolution DTMs from unmanned aerial vehicles (UAVs) opens new horizons for detailed assessment of soil erosion with hydrological models, but the effects of DTM resolution on model outputs at this scale have not been systematically tested. This study combines plot-scale soil erosion measurements, UAV-derived DTMs, and spatially explicit soil erosion modelling to select an appropriate spatial resolution based on allowable loss of information. During 39 precipitation events, sediment and soil samples were collected on
five bounded and unbounded plots and four land covers (forest, fallow,
maize, and eroded bare land). Additional soil samples were collected across
a 220 ha watershed to generate soil maps. Precipitation was collected by two rain gauges and vegetation was mapped. A total of two UAV campaigns over the watershed resulted in a 0.60 m spatial-resolution DTM used for resampling to 1, 2, 4, 8, and 15 m and a multispectral orthomosaic to generate a land cover map. The OpenLISEM model was calibrated at plot level at 1 m resolution and then extended to the watershed level at the different DTM resolutions. Resampling the 1 m DTM to lower resolutions resulted in an overall reduction in slope. This reduction was driven by migration of pixels from higher to lower slope values; its magnitude was proportional to resolution. At the watershed outlet, 1 and 2 m resolution models exhibited the largest
hydrograph and sedigraph peaks, total runoff, and soil loss; they
proportionally decreased with resolution. Sedigraphs were more sensitive
than hydrographs to spatial resolution, particularly at the highest
resolutions. The highest-resolution models exhibited a wider range of
predicted soil loss due to their larger number of pixels and steeper slopes. The proposed evaluation method was shown to be appropriate and transferable for soil erosion modelling studies, indicating that 4 m resolution (<5 % loss of slope information) was sufficient for describing soil erosion variability at the study site.
Implementation of Primary Healthcare Services in Community Health Stations in Highly Urbanized City
Authors: Gella Hanna B. , Caelian Merlita V. 
Published: October 2021

Primary healthcare is integral to the Sustainable Development Goal (SDG) of ensuring healthy lives and promoting well-being. A descriptive study assessed the implementation of primary healthcare services in community health stations through a researcher-made questionnaire among healthcare providers and beneficiaries of 30 community health stations. The results revealed that, as a whole, the implementation of primary healthcare services in community health stations is great, with maternal and child healthcare implemented to a very great extent while the treatment of non-communicable diseases to a great extent only. The major challenges encountered are the lack of medical drugs, supplies and equipment, and medical professionals. Primary healthcare has made contributions to the community's health improvement; however, challenges imply that the quality and efficiency of the services need improvement. The study contributed to new knowledge on implementing healthcare at the lowest level of government, emphasizing patient-centeredness.
تعريف مُسبب مرض العفن السُخامي على الأشجار في محيط جامعة عمر المختار – البيضاء -ليبيا
Authors: عبدالرواف إيمان جبريل , الجالي زهرة ابراهيم , الوحش كاملة عبد الرحيم 
Published: October 2021

أُجريت الدراسة خلال الموسم 2017-2018 بهدف تعريف مُسبب مرض العفن السُخامي على أوراق بعض النباتات في محيط الجامعة شملت التين، الزيتون والدفلة، اللوز، الخروب، الكافور، الإكليل، الصبار النجمي، الورد البلدي، البزرومية ونباتات أخرى، حيث جرت زيارات أسبوعية لجمع العينات الورقية، وفحصها لمُلاحظة وجود المرض والحشرات المُرافقة، كما تم عزل مُسبب المرض على الوسط الغذائي آجار البطاطس والسكروز Potato sucrose Agar (PSA)، وتعريفه بناءً على صفاته المزرعية، والشكلية، واختبار قُدرته على إصابة النسيج النباتي. أثبتت الدراسة وجود المرض على أشجار الزيتون والتين والدفلة مرافقاً لوجود الحشرات الماصة، في حين خلت بقية النباتات من الإصابة عدا الصبار النجمي، وبعض الحشائش. كانت أعلى نسبة وشدة إصابة بالمرض (75.5% و69%) سُجلت على أشجار الزيتون يليها الدفلة ثم التين. نتائج العزل أثبتت تسجيل الفطر Alternaria alternata على الأوراق، فيما برهنت نتائج اختبار القدرة على إصابة نسيج النبات عدم ظهور أي أعراض مرضية على الأوراق المعداة اصطناعياً.
Association between IL-1B (-511)/IL-1RN (VNTR) polymorphisms and type 2 diabetes: a systematic review and meta-analysis
Authors: Jiao Juan , Wang Zhaoping , Guo Yanfei , Liu Jie , Huang Xiuqing , Ni Xiaolin , Gao Danni , Sun Liang , Zhu Xiaoquan , Zhou Qi , Yang Ze , Yuan Huiping 
Published: October 2021

Interleukin-1 (IL-1) plays an essential role in the immune pro-inflammatory process, which is regarded as one of many factors in the development of type 2 diabetes mellitus (T2DM). Several case-control studies have illustrated the association of the IL-1B (-511) (rs16944, Chr 2:112,837,290, C/T Intragenic, Transition Substitution) and IL-1RN (VNTR) (gene for IL-1 receptor antagonist, IL-1RA, 86 bp tandem repeats in intron 2) polymorphisms with T2DM risk. However, the results were inconsistent and inconclusive. We performed a meta-analysis (registry number: CRD42021268494) to assess the association of the IL-1B (-511) and IL-1RN (VNTR) polymorphisms with T2DM risk. Random-effects models were applied to calculate the pooled ORs (odds ratios) and 95% CIs (confidence intervals) to test the strength of the association in the overall group and subgroups stratified by ethnicity, respectively. Between-study heterogeneity and publication bias were evaluated by the Q-test, I2 statistic, Harbord test, and Peters test accordingly. Sensitivity analyses were also performed. A total of 12 publications evaluating the association of IL-1B (-511) and IL-1RN (VNTR) polymorphisms with the risk of T2DM development were included. The meta-analysis showed that IL-1RN (VNTR) was related to the increasing development of T2DM risk in the recessive model (OR = 1.62, 95% CI [1.09–2.42], Phet = 0.377, Pz = 0.018) and in the homozygous model (OR = 2.02, 95% CI [1.07–3.83], Phet = 0.085, Pz = 0.031), and the IL-1RN 2* allele was found a significant association with evaluated T2DM risk in all ethnicities (OR = 2.08, 95% CI [1.43–3.02], Phet < 0.001, Pz < 0.001) and in EA (OR = 2.01, 95% CI [1.53–2.66], Phet = 0.541, Pz < 0.001). Moreover, stratification by ethnicity revealed that IL-1B (-511) was associated with a decreased risk of T2DM in the dominant model (OR=0.76, 95% CI [0.59–0.97], Phet = 0.218, Pz = 0.027) and codominant model (OR = 0.73, 95% CI [0.54–0.99], Phet = 0.141, Pz = 0.040) in the East Asian (EA) subgroup. Our results suggest that the IL-1RN 2* allele and 2*2* homozygous polymorphism are strongly associated with increasing T2DM risk and that the IL-1B (-511) T allele polymorphism is associated with decreasing T2DM risk in the EA subgroup.
Regulation of Molecular Orientations of A–D–A Nonfullerene Acceptors for Organic Photovoltaics: The Role of End‐Group π–π Stacking
Authors: Zheng Wenyu , Liu Jianchuan , Guo Yuan , Han Guangchao , Yi Yuanping 
Published: October 2021

AbstractIncreasing horizontal and face‐on orientations of the active molecules in organic solar cells is critical to improve light absorption, charge mobility, and exciton diffusivity for high photovoltaic efficiency. However, how to effectively control the molecular orientations is challenging and still unclear. Here, the molecular self‐assembly and orientation formation are elucidated for a series of acceptor–donor–acceptor (A–D–A) small‐molecule acceptors (SMAs) by atomistic molecular dynamics simulations. The results indicate that the A–D–A molecules tend to assemble via the end‐group π–π stacking at the liquid–vapor interfaces during solvent evaporation, which is beneficial to enhance horizontal and face‐on orientations. Remarkably, the order of both horizontal and face‐on orientations in the films shows a good linear correlation with the number of π–π stacking among all the A–D–A SMAs. The π–π stacking is found to be cooperatively controlled by both the end‐group π–π interaction and side‐chain steric hindrance. This work provides the rationalization for the different molecular orientations in a wide range of A–D–A SMAs and is useful to improve the horizontal and face‐on orientations for high‐performance organic photovoltaics.
Delivery of MiR335‐5p‐Pendant Tetrahedron DNA Nanostructures Using an Injectable Heparin Lithium Hydrogel for Challenging Bone Defects in Steroid‐Associated Osteonecrosis
Authors: Li Donghai , Yang Zhouyuan , Luo Yue , Zhao Xin , Tian Meng , Kang Pengde 
Published: October 2021

AbstractCorticosteroids‐induced Dickkopf‐1 (DKK1) upregulation and Wnt signaling inhibition result in bone metabolism disorder and steroid‐associated osteonecrosis (SAON). Implanting biomaterials to regulate the Wnt pathway is a promising method to repair challenging bone defects associated with SAON. Here, tetrahedral DNA nanostructures (TDNs) are fabricated as gene carriers to deliver MiR335‐5p, which targets DKK1 translation. Heparin lithium hydrogel (Li‐hep‐gel) is synthesized to act as a lithium and MiR@TDNs delivery agent. Finally, the repair effects on challenging bone defect in SAON using a MiR@TDNs/Li‐hep‐gel composite are assessed in vivo. The results reveal that MiR@TDNs are absorbed by bone mesenchymal stem cells (BMSCs) and increase cell viability and reduce apoptosis. Moreover, MiR@TDNs promote alkaline phosphatase expression and calcium nodular deposition, decrease lipid droplet expression of BMSCs, and improve vascular endothelial growth factor secretion and vascular‐like structure formation in vitro. After MiR@TDNs/Li‐hep‐gel is implanted into the SAON model, the internal bone defect of osteonecrosis is repaired with a large area of new bone accompanied with neovascularization and reduced empty lacunae. In conclusion, MiR@TDNs/Li‐hep‐gel can provide dual delivery of lithium and MiR@TDNs, which synergistically upregulate the Wnt signaling pathway, enhancing bone regeneration in challenging bone defects, and can be potentially used in SAON repair.