bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Caffeine Citrate and Incidence of Acute Kidney Injury in Preterms
Authors: Mansour Halah Tarek Mohammed , Elsharkawy Hamed Mohamed Mohamed , Hazzaa Sahar Mohey Eldin , Nassar Mohammed Abd-Ellatif 
Published: November 2021

Background: As a result of prematurity, Acute kidney injury (AKI) occurs commonly in preterm neonates and is associated with increased morbidity and mortality. (AKI) is defined as a rapid, potentially reversible deterioration in renal functions sufficient to result in accumulation of nitrogenous wastes in the body.
Aim of the Study: the aim of this study was to determine whether preterm neonates who took caffeine citrate from the first day after birth were less likely to AKI within the first 7 days.
Patients and Methods: This case control study was conducted on 100 preterm neonates at Neonatal Intensive Care Units (NICUS), Pediatric Department, Tanta University with gestational age less than (30 weeks) were grouped into group A and B. Group A 50 preterm neonates who received caffeine citrate from the first day after birth with dose (20 mg/kg) loading dose, and (5 mg/kg/dose) every 24hrs of maintenance dose, given as slow intravenous infusion over twenty to thirty minutes for a week. Group B 50 preterm neonates who did not receive caffeine citrate.
Inclusion Criteria: all preterms <30 weeks admitted within first 24 hours after birth presented by respiratory distress according to Downes score.
Exclusion Criteria: newborns with congenital heart disease except non-significant PDA, neonatal mortality < 48 h of life, clinical signs suggest chromosomal anomalies, newborns with congenital renal anomalies.

Hematological Investigations: serum albumin, serum creatinine, blood urea.
Urinary Investigations: measuring urine output.

Results: There was a statistically significant difference between the two studied groups as regard serum creatinine in day (5,7) (p<0.001), urea in day 7 (p value <0.001), serum albumin in day (5,7) (p value ≤ 0.05), urine output in day (4,5,6,7) (p value ≤0.05), AKI incidence (p value <0.001).
Conclusion: Caffeine Citrate administration in preterm neonates from the first day of life for one week was associated with reduced occurrence and severity of AKI.
Comparison of Normal Ratio Method and Distance Power Method for Estimating Missing Rainfall Data with Three Neighboring Stations
Authors: A. De Asis Celeste 
Published: November 2021

This study compared the performances of Normal Ratio Method and Distance Power Method as a tool for estimating missing rainfall data. The data utilized are the rainfall data of the three neighboring station of Catarman, Northern Samar, Philippines. These stations are Catbalogan Station (Samar Province), Legazpi (Bicol Province) and Masbate (Masbate Province).
The observed daily rainfall data for the Catarman (Northern Samar), Catbalogan, Legazpi, and Masbate were obtained from the Philippine Atmospheric Geographical Astronomical Services Administration. The monthly rainfall were computed for the three (3) neighboring stations (Catbalogan, Legazpi, Masbate).
The evaluation used the T-test for correlated samples and the Pearson’s Correlation Coefficient for the monthly rainfall data computed of the three neighboring Station of Catarman, Northern Samar with the three neighboring stations. Based from the results, Normal Ratio Method performs better than Distance Power Method as applied to three neighboring stations.
Perception of Dental Aesthetics among Dental Students; a Cross-sectional Study in Riyadh, Kingdom of Saudi Arabia
Authors: Alanazi Mashari Mulayfi , Alsanie Sulaiman Abdullah , Alotaibi NawafJazaa , Alenezi Ahad K. , Abaradie Waleed , M. Alhussain Badr Soliman , Ansari Shahzeb Hasan 
Published: November 2021

Background: Dental aesthectics is now a necessary area in the field of dentistry, and new graduates' perceptions should be investigated. Hence the present cross-sectional study aimed to assess the perception about dental aesthetics among clinical interns, dentistry interns, and pre-clinical interns in dental colleges on Saudi Arabia.
Materials and Methods: The study subjects comprises of all above three (clinical interns, dentistry interns, and pre-clinical interns) groups volunteered from different colleges. Perception about dental aesthetics was measured using a 14 item questionnaire. Chi-square test was performed on SPSS to determine the statistically significant differences (p<0.05) across gender and dentistry level.
Results: Findings revealed 61% of the participants were male while 39% were female. Among them, 26% were pre-clinical interns, 41% were dental interns and 33%were clinical students. All the particiants reported some kind of dissatisfaction with appearance of their teeth and males were more satisfied and confident about their teeth and smile than females.
Conclusion: To conclude, in the present study male participants and clinical students were confident about their smile as compared to female while dental interns thought others have good smile. The study reported the significant gender differences on looking at magazines, having whiter teeth, they way gums look and putting hand over mouth while non-significant differences across dentistry level.
Circulating Leptin, Insulin and Thyroid Profile Levels in Different Age Groups of Women Population of Manipur, India
Authors: Singh Loushambam Samananda , Sharma Laimayum Amarnath , Govindaraj Y. , Devi K. S. H. Gomti , Kanan W. , Ranjit R. K. 
Published: November 2021

Background: Age is linked to a number of hormonal disorders. This study was designed to look for changes in leptin, insulin, and thyroid profile concentrations in women of various ages.
Materials and Methods: This study was carried out in the Department of Physiology, Regional Insititute of Medical Sciences, Imphal. Female subjects (350 participants) between the ages of 20 and 65 were recruited. Subjects were grouped as pre-menopause (< 40 age), menopause (≥ 40 to < 50 age) and post-menopause (≥ 50 age). Blood samples were separated serum and estimated levels of leptin, insulin and thyroid profile levels. Statistical calculation was done using SPSS software version 26, at P < 0.05 as significant.
Results: Body mass index (BMI) had significant changes in different age groups (P < 0.05), but the levels were not in the higher range of BMI. Serum levels of leptin, insulin, T4 (thyroxine) and TSH (thyroid stimulating hormone) were found no significant differences among the different age groups.
Conclusion: Study demonstrates that age has no effect on the levels of leptin, insulin, T4, and TSH in this Manipuri women's group.
Histopathological Evaluation of Ficus Capensis Aqueous Extract on Liver, Kidney, Intestine and its Potentials in Treatment of Anaemia
Authors: Okorie Nnaemeka , Obeagu Emmanuel Ifeanyi , Obinna Ede Kenneth , Agada Uchechukwu Nelson , A. Obi Ihuoma , Uzor Simon , Ogbonna Nwachi Idume , Uche Bethel Mmesomachi , Ewa Ibe Onyekachi , Nwovu A.I. 
Published: November 2021

Ficus capensi is a nature of Nigerian multi ethnic group and it is been identified and called differently dy ethnic groups for example, igbo call it akporo, hausa -uwaryara,etc. The aim of the this research titlled; Histopathologica evaluation of ficus capensis ethanol extract on liver, kidney, intestine and it potentials in the treatment of anaemia is to evaluate the effect of leaf and stem back extract of ficus capensis in the treatment potential of anaemia and it’s histopathological effect on liver, kidney, and large intestine of wister rat. The animals were grouped into 5(A, B, C, D & E) and anaemia induced with cirfuroxime in all the groups except group E which is the negative control whereas other groups were treated with vitamins and leaf & stem bark of Ficuscapensis ethanol extract; group C wasn’t treated and it’s regarded as positive control. The blood sample were collected suing cardiac puncture and liver,kidney and large intestine were all harvested following dissection upon 14 days treatment and experimental termination. All the samples collected were analysed using standard methods. There was significant difference in body weight, same was observed in multiple comparism test on packed cell volume and haemoglobin after treatment with Vitamins, leaf and stem bark of Ficus capensis ethanol extract. It was also observed that there was relative distortion of large intestinal lumen, kidney and hepatocytes. Ficusis capensis leaf and bark has shown antianaemic potentials, however; its toxic effect on the selected organs (liver, Kidney and large intestine) called for caution among users.
Predictive Analysis of Real-Time Strategy using Face book’s Prophet Model on Covid-19 Dataset of India
Authors: Kumar Pankaj , Sharma Renuka , Singh S. K. 
Published: November 2021

The global epidemic of the novel coronavirus (COVID-19) called SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has infected millions and killed millions. The prevalence of the virus is of paramount importance in identifying future infections and preparing healthcare facilities to avoid death. Accurately predicting the spread of COVID-19 is a challenging analytical and practical task for the research community. We can learn to use predictive analytics to predict the positive outcomes of these risks. These predictive analytics can look at the risks of past successes and failures.
In this paper, the Facebook prophet model discusses the number of large-scale cases and deaths in India based on daily time-series data from 30 January 2020 to 30 April 2021, for forecasting and visualization. The covid-19 pandemic could end prematurely if social distancing and safety measures are required to stabilize and control is required to achieve treatment in India. This paper suggests that the Prophet Model is more effective in predicting COVID-19 cases. The forecast results will help the government plan strategies to prevent the spread of the coronavirus.
Biodegradable RF Metamaterial Perfect Absorber for Wireless Soil pH Monitoring
Authors: Sato Soma , Sakabe Ken , Onoe Hiroaki , Kan Tetsuo 
Published: December 2024

AbstractA wireless soil pH sensor is proposed using a sheet‐type perfect absorber metamaterial. The sensor utilizes a high‐impedance surface metamaterial, which functions as a perfect absorber at the resonant frequency. This sensor has a uniform water‐soluble Mg film at the bottom coated with hydroxyapatite that degrades depending on the pH, and a periodic square split ring resonator metamaterial structure made on top of a lossy dielectric plate. The sensor detects the dissolution of the metamaterial due to soil pH conditions through the electromagnetic wave reflection response at GHz frequency. Because of the perfect absorbing characteristics, the influence of soil on the metamaterial's electromagnetic response is blocked, allowing for robust measurement regardless of soil type. By coating the Mg with hydroxyapatite, the difference between acidic (pH = 3.0) and neutral soils can be detected by the time difference by a factor of three in the reflectance change from 40% to 75% reflectance change, indicating a transition from absorptive to reflective of the metamaterial's response, at the resonant frequency of 4.12 GHz.
Fiber‐Tip Microgripper with Sub‐Milliwatt Photoactuation
Authors: Cheng Chiao‐Yu , Chen Chun‐Wei , Li Cheng‐Chang , Jau Hung‐Chang , Wang Cheng‐Yu , Feng Ting‐Mao , Wei Jia , Yu Yanlei , Lin Tsung‐Hsien 
Published: December 2024

AbstractWhile many micromanipulators offer advanced functionality, they often require relatively high power (10–100 mW) for actuation and are not easily integrated into existing diagnostic systems like endoscopes. This work presents an optically controlled fiber‐tip microgripper, which combines the light‐guiding capability of an optical fiber with the photoactuation of an azobenzene liquid crystal polymer. This microgripper opens and closes its fingers (polymer strips) using visible light at power levels as low as ≈0.3 mW and retains its shape without continuous illumination, providing notable energy efficiency. It is demonstrated to grasp, transport, and release a piece of optical fiber, a relatively heavy micro‐object. The use of a fiber to tether the microgripper and deliver pump light enables micromanipulation in narrow, hard‐to‐reach locations where external illumination may be impractical. Its compact design, low power consumption, and fiber‐optic compatibility position this microgripper—and its potential variants—as a promising tool for robotic, biomedical, and microfluidic applications.
Targeting Deltex E3 Ubiquitin Ligase 2 Inhibits Tumor‐associated Neutrophils and Sensitizes Hepatocellular Carcinoma Cells to Immunotherapy
Authors: Wu Xiaoling , Chen Jiafeng , Chen Yiran , Song Shushu , Fang Yuan , Mao Shengwei , Gao Jun , Zhu Guiqi , Qu Weifeng , Zhao Qianfu , Yang Rui , Guan Zhiqi , Chu Tianhao , Bu Yichao , Wang Yi , Chen Fangyu , Zhou Jian , Fan Jia , Tang Zheng , Liu Weiren , Ruan Yuanyuan , Shi Yinghong 
Published: December 2024

AbstractSeveral E3 ligases have been found to affect the immune microenvironment of hepatocellular carcinoma (HCC) and lead to the resistance of immunotherapy. In this study, genes of E3 ligases are screened based on The Cancer Genome Atlas (TCGA) dataset. Through cytometry by time of flight (CyTOF), flow cytometry, and further experiments, Deltex E3 ubiquitin ligase 2 (DTX2) in HCC cells is identified to promote the infiltration and polarization of tumor‐associated neutrophils (TANs) with a protumor phenotype, thus attenuating the infiltration and cytotoxicity of CD8+ T cells partially through C‐X‐C motif chemokine 2 (CXCL2) and C‐X‐C motif chemokine 6 (CXCL6). Mechanistically, DTX2 can interact with histone H2B and promote its monoubiquitination at lysine120 (H2BK120ub1), thereby increasing CXCL2 and CXCL6 transcription through histone epigenetic regulation. Different tumor models in vivo demonstrated that DTX2 inhibitor treatment inhibited tumor growth and sensitized HCC cells to the therapeutic effects of programmed cell death protein 1 (PD‐1) antibody. In summary, this study identifies DTX2 as a potential target for HCC immunotherapy.
Nutrient uptakes and use efficiency of cassava under different moisture conditions
Authors: Janket A. , Jogloy S. , Vorasoot N. , Toomsan B. , Kaewpradit W. , Theerakulpisut P. , Holbrook C. C. , Kvien C. K. , Banterng P. 
Published: December 2024

AbstractPrecise fertilization based on crop needs is important for optimal yield and cost‐effectiveness. This study aimed to investigate nutrient uptakes in cassava under different planting dates and irrigation conditions (W). Two‐year field trials were conducted in the early (ERS) and post‐rainy seasons (PRS), with nutrient uptakes measured at five growth stages. Planting dates had a greater impact on nutrient uptakes, accumulation rates, nutrient harvest index (NHI), and nutrient use efficiency (NUE) than W. In the ERS, the nutrients accumulated rapidly at the early to mid‐growth stages, while this occurred at the mid to late growth stages for the PRS. Nutrient uptake was higher in ERS than PRS, with W differenced only in ERS 2015. Irrigation during the mid to late growth stages increased the nutrient uptake, NHI, NUE, and yield for the ERS (2015), with less impact on the PRS. In contrast, the PRS significantly improved yield, accumulation in storage roots, NHI, and NUE. Total nutrients accumulated by the whole plant (kg ha−1) were N (207–383) > K (182–401) > Ca (180–202) > Mg (62–82) > P (42–76) > S (11–25), Fe (2.60–7.64) > Mn (1.60–3.34) > Zn (0.48–0.62) > B (0.15–0.25) > Cu (0.11–0.19) > Mo (0.026–0.055). Nutrients with high NHI were K (0.41–0.64), Zn (0.35–0.58), N (0.28–0.56), Cu (0.16–0.61), B (0.16–0.52), and Mo (0.19–0.62), and lower NHI were P (0.27–0.47), Mg (0.17–0.37), S (0.15–0.48), Fe (0.15–0.34), Ca (0.09–0.19), and Mn (0.04–0.31). These findings will improve nutrient requirement guidelines for seasonal fertilizer recommendations for cassava in Thailand.
The role of neuropsychological assessment in the evaluation of patients with cognitive‐behavioral change due to suspected Alzheimer's disease and other causes of cognitive impairment and dementia
Authors: Shaughnessy Lynn W. , Weintraub Sandra 
Published: December 2024

AbstractThe Alzheimer's Association convened a Diagnostic Evaluation, Testing, Counseling and Disclosure Clinical Practice Guideline workgroup to help combat the major global health challenges surrounding the timely detection, accurate diagnosis, and appropriate disclosure of mild cognitive impairment (MCI) or dementia due to Alzheimer's disease (AD) or other diseases that cause these types of cognitive‐behavioral disorders. The newly published clinical practice guidelines are proposed as a structured approach to evaluation. The purpose of the present article is to provide a clinical perspective on the use of neuropsychology within the new framework and practice guidelines outlined under the Diagnostic Evaluation, Testing, Counseling and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD) recommendations for primary care and specialty care. Neuropsychological evaluation is a critical component in supporting early and accurate diagnosis and staging, characterizing the clinical profile, assessing trajectory over time, and providing recommendations specifically tailored to the individual and their care team.Highlights
Reviews the neuropsychological evaluation component of the new framework and clinical practice guidelines outlined under the Alzheimer's Association clinical practice guidelines for the Diagnostic Evaluation, Testing, Counseling and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD).
Examines the utility of neuropsychological evaluation in the assessment of Alzheimer's Disease and Related Disorders (ADRD).
Supports a basis for neuropsychology in early and accurate diagnosis and staging, characterizing the clinical profile, assessing trajectory over time, and providing recommendations specifically tailored to the individual and their care team.
Longitudinal synaptic loss versus tau Braak staging in amnestic mild cognitive impairment
Authors: Vanderlinden Greet , Koole Michel , Michiels Laura , Lemmens Robin , Vandenbulcke Mathieu , Van Laere Koen 
Published: December 2024

AbstractINTRODUCTIONThe longitudinal progression of synaptic loss in Alzheimer's disease (AD) and how it is affected by tau pathology remains poorly understood.METHODSThirty patients with amnestic mild cognitive impairment (aMCI) and 26 healthy controls underwent cognitive evaluations and tau, synaptic vesicle protein 2A (SV2A), and amyloid positron emission tomography. Twenty‐one aMCI underwent 2‐year follow‐up (FU) investigations.RESULTSTau levels in aMCI increased longitudinally in Braak regions III through VI but not in Braak regions I and II. SV2A decreased longitudinally in all Braak regions in aMCI. Baseline tau was negatively associated with longitudinal SV2A loss in early Braak regions and with SV2A at FU across regions. Baseline tau and longitudinal change in SV2A were associated with longitudinal cognitive decline.DISCUSSIONTau accumulation reaches a plateau in early Braak regions already in the aMCI stage of AD. In early Braak regions, the association between baseline tau and longitudinal SV2A loss might reflect synaptic dysfunction caused by tau pathology.Highlights
Tau accumulation reached a plateau in early Braak regions in amnestic mild cognitive impairment (aMCI) patients.
aMCI patients show widespread longitudinal decrease in synaptic vesicle protein 2A (SV2A) over 2 years.
Baseline tau was predictive for longitudinal SV2A loss.
The tau–SV2A relation showed individual variability and was negative across patients.
Baseline tau and longitudinal SV2A change were associated with change in cognition.
Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies
Authors: Gibson Lucy L. , Gonzalez Maria C. , Ashton Nicholas J. , Tovar‐Rios Diego , Blanc Frédéric , Pilotto Andrea , Lemstra Afina , Paquet Claire , Ballard Clive , Zetterberg Henrik , Aarsland Dag ,   the European–Dementia With Lewy Bodies (E‐DLB) Consortium
Published: December 2024

AbstractINTRODUCTIONNeuropsychiatric symptoms (NPSs) are common in dementia with Lewy bodies (DLB) but their neurobiological mechanisms are poorly understood.METHODSNPSs and cognition were assessed annually in participants (DLB n = 222; Alzheimer's disease [AD] n = 125) from the European DLB (E‐DLB) Consortium, and plasma phosphorylated tau‐181 (p‐tau181) and p‐tau231 concentrations were measured at baseline.RESULTSHallucinations, delusions, and depression were more common in DLB than in AD and, in a subgroup with longitudinal follow‐up, persistent hallucinations and NPSs were associated with lower p‐tau181 and p‐tau231 in DLB. In adjusted linear mixed‐effects models, hallucinations at baseline were associated with greater longitudinal cognitive impairment in DLB, with a significant interaction with p‐tau231.DISCUSSIONHigher p‐tau181 and p‐tau231 levels were associated with a lower longitudinal risk of NPSs and hallucinations in early‐stage DLB. However, the interaction between hallucinations and p‐tau231 suggests that when AD co‐pathology and hallucinations do co‐exist in DLB that they may synergistically exacerbate cognitive decline.Highlights
Neuropsychiatric symptoms (NPSs) were more common in dementia with Lewy bodies (DLB) than in Alzheimer's disease (AD).
Lower plasma phosphorylated tau‐231 (p‐tau231) and p‐tau181 levels were associated with persistent hallucinations in DLB.
Lower plasma p‐tau231 and p‐tau181 levels were associated with an increased risk of persistent NPSs in early DLB.
Hallucinations at baseline were associated with greater cognitive dysfunction in DLB, and there was an interaction with p‐tau231.
Early midlife ovarian removal is associated with lower posterior hippocampal function
Authors: Brown Alana , Gravelsins Laura , Gervais Nicole J. , Rieck Jenny , Zhao Sophia , Duchesne Annie , Witt Suzanne T. , Kämpe Robin , Olsen Rosanna , Barense Morgan , Classon Elisabet , Theodorsson Elvar , Ernerudh Jan , Åvall‐Lundqvist Elisabeth , Kjølhede Preben , Engström Maria , Shao Zhuo , Bernardini Marcus , Jacobson Michelle , Rajah M. Natasha , Grady Cheryl , Einstein Gillian 
Published: December 2024

AbstractINTRODUCTIONWomen with early bilateral salpingo‐oophorectomy (BSO) have greater Alzheimer's disease (AD) risk than women with spontaneous menopause (SM), but the pathway toward this risk is understudied. Considering associative memory deficits may reflect early signs of AD, we studied how BSO affected brain activity underlying associative memory.METHODSEarly midlife women with BSO (with and without 17β‐estradiol therapy [ET]) and age‐matched controls (AMCs) with intact ovaries completed a face–name associative memory task during functional magnetic resonance imaging. Hippocampal activity along the anteroposterior axis during associative encoding and retrieval was compared among three groups (BSO [n = 28], BSO+ET [n = 35], AMCs [n = 40]).RESULTSBoth BSO groups (with and without ET) showed lower posterior hippocampal activation during encoding compared to the AMC group. However, this difference in activation was not significantly correlated with associative memory task performance.DISCUSSIONEarly 17β‐estradiol loss may influence posterior hippocampal activity during associative encoding, possibly presaging late‐life AD.Highlights
After ovarian removal, changes in hippocampal function may affect dementia risk.
Midlife ovarian removal is associated with less activation in the posterior hippocampus.
Estradiol therapy may ameliorate alterations in brain function during learning.