bluuebunny/crossref_metadata_2025_split huggingface dataset:
Covid-19 Patient Mortality Risk Classification Using Bayesian Binary Logistic Regression
Authors: Shobri Muhammad Qolbi , Yanuar Ferra , Devianto Dodi 
Published: September 2021

At the end of 2019 the world was shocked by a new disease caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2). The disease is called Covid-19 (Coronavirus Disease). The mortality rate due to disease is increasing every day. In Indonesia as of April 2021, confirmed Covid-19 patients who died reached 42,530 patients, seeing the high mortality rate of Covid-19 patients so it needs to be studied further so that the risk of death of these Covid-19 patients can be minimized. This research utilizing binary logistic regression with Bayesian method parameter estimation. In this study, the predictor variables used were in the form of categories that each category in the predictor variables was assumed to have the same risk of death risk of Covid-19 patients. The results of this study indicate that the number of comorbids has a significant effect on the risk of death of Covid-19 patients, the more the number of comorbids suffered by the patient, the higher the risk of death of the patient. The accuracy of this method in classifying data is 84.68%.
Reporting of Comorbidities in Total Hip and Knee Arthroplasty Clinical Literature
Authors: Sinclair SaTia T. , McConaghy Kara M. , Emara Ahmed K. , Klika Alison K. , Piuzzi Nicolas S. 
Published: September 2021

Background:
The effects of comorbid disease remain an area of interest. Concurrent diagnoses not only affect clinical outcomes but also affect health-care reimbursement. As the rate of arthroplasty increases, consistent risk stratification is imperative. Therefore, our aim was to ascertain how comorbidities have been reported in the recent total hip arthroplasty (THA) and total knee arthroplasty (TKA)-related literature; we also wanted to quantify the use of comorbidity scores for the assessment of comorbid disease in arthroplasty research.

Methods:
A systematic review of the recent THA and TKA literature that was published between January 1, 2019, and September 21, 2020, was performed using the PubMed and MEDLINE databases. Clinical studies that provided data on comorbidities were evaluated for method of comorbidity reporting. The prevalence of comorbidity reporting was assessed, and the manner of reporting was analyzed.

Results:
Among 659 articles, a total of 207 studies (31.4%) reported comorbidities and met our inclusion criteria. Of the 207 studies that reported comorbidities, only 57% used a comorbidity index to report comorbid disease. Of all of the indices, the American Society of Anesthesiologists (ASA) Physical Status Classification System was the score that was most commonly used (TKA, 86.2%; THA, 83.3%). Additional scores were used at varying frequencies. For TKA, the scores included the Charlson Comorbidity Index (CCI) (15.5%); the New York Heart Association (NYHA) Functional Classification (3.4%); and the CCI-Deyo (adapted by Deyo et al.), the age-adjusted CCI, the Cumulative Illness Rating Scale (CIRS), and the Readmission Risk Assessment Tool (RRAT) (1.7% each). For THA, the scores included the CCI (16.7%), the Elixhauser Comorbidity Measure (ECM) (6.7%), and the CCI-Deyo (1.7%).

Conclusions:
Considering the impact of comorbid disease on outcomes, complications, and, ultimately, reimbursement, standardized risk stratification in arthroplasty is necessary. Current studies demonstrate inconsistent comorbidity reporting, making it challenging to further characterize the impact of comorbidities on outcomes. Future research should target the development of a standardized data-driven model for comorbidity assessment in the orthopaedic patient population.
RECHARGE – A Brief Psychological Intervention to Build Resilience in Health Care Workers During the COVID-19 Pandemic: Study Protocol for a Randomized Controlled Trial
Authors: Morina Naser , Weilenmann Sonja , Dawson Katie S , Ernst Jutta , Zanitti Zelim , von Känel Roland , Schick Matthis , Spiller Tobias R , Bryant Richard A 
Published: September 2021

Abstract
Background: Health care workers (HCWs) typically face high work demands, which can be exacerbated during crises such as the COVID-19 pandemic. These demands may result in high psychological distress and reduced work performance. Although there are psychological interventions to reduce stress in HCWs under normal working circumstances, no intervention have been specifically developed to addresses stress in the context of public health crises such as the current COVID-19 pandemic. This study aims to evaluate the effectiveness of RECHARGE, a psychological intervention specifically developed for HCWs to reduce distress in HCWs. It is based on a brief crisis intervention of the World Health Organization that teaches basic stress management skills from cognitive behavioural therapy. Methods: A randomized controlled trial (RCT) will be carried out among 160 physicians, nurses, and other HCWs working in hospitals in Switzerland during COVID-19, who are at least moderately distressed. HCWs will be randomised to RECHARGE (n=80) or active treatment as usual (ATAU) (n=80). Pre-intervention (week 1, T1), post-intervention (week 4, T2) and 2-month follow-up (week 12, T3) assessments include psychological distress as primary outcome, and indicators of mental ill-being (worries, anxiety, depression, burnout, traumatic stress, distress due to perceived ethical dilemma) and work performance as secondary outcomes. These outcomes will be compared between HCWs in the RECHARGE and ATAU groups. Discussion: RECHARGE is an evidence-informed brief, flexible, easily scalable, fully online psychological program that allows delivery in pandemic conditions, including social isolation. Therefore, this program can serve as a much-needed template for an intervention to reduce stress and enhance work performance in HCWs during the COVID-19 pandemic. If proven effective, RECHARGE may not only be used to reduce elevated stress in HCWs in Switzerland, but also globally. Key words: COVID-19, randomised controlled trial, protocol, health care workers; psychological treatment; distress, crisis intervention; pandemic; resilience;
Mutation-specific reporter for optimization and enrichment of prime editing
Authors: Schene Imre , Joore Indi , Baijens Jan , Stevelink Remi , Kok Gautam , Shehata Sawsan , Ilcken Eveline , Bolhuis Dian , Rees Rosalie van , Spelier Sacha , Doef Hubert van der , Beekman Jeffrey , Houwen Roderick , Nieuwenhuis Edward , Fuchs Sabine A. 
Published: September 2021

Abstract
Prime editing is a versatile genome-editing technique. However, some genomic sites remain difficult to edit and optimal design of prime-editing tools is elusive. We present a fluorescent prime editing and enrichment reporter (fluoPEER), which can be tailored to any genomic target site. This system rapidly and faithfully ranked the efficiency of prime edit guide RNAs (pegRNAs) and any prime editor protein, including novel variants with flexible protospacer adjacent motif (PAM) recognition. We applied fluoPEER to instruct correction of pathogenic variants in patient cells and found that plasmid-editing enriched for editing at the genomic target site. Transcriptomic analysis of reporter-edited cells revealed that successful prime editing was associated with expression of DNA repair genes. Together, our results show that fluoPEER can be employed for rapid and efficient correction of patient cells, selection of gene-edited cells, and elucidation of cellular mechanisms needed for successful prime editing.
A Randomized Response Technique for Reducing the Effect of Initial Non-response of the Regression Estimator in Panel Surveys
Authors: Khan Mursala 
Published: September 2021

Abstract
The results of Sample surveys play a vital role in decision making. One of the main issues being faced by survey statisticians during the collection of survey data is the problem of non-response which may affect survey cost and accuracy of estimates. The problem of non-response becomes more severe if the survey contains sensitive questions like related to family planning methods, use of drugs. To diminish the non-response rate arising in the case of direct questioning (DQ) technique, Warner (1965) proposed an indirect survey technique known as the randomized response (RR) technique. He addressed this problem for a cross-sectional data. This method is a well-known procedure that produces more valid responses on sensitive questions in surveys. The method avoids the direct link between respondent’s response and the sensitive question through the help of a randomization device. Thereby protecting respondent’s privacy which in turn greatly increases survey response rate. However, due to the complex nature of panel estimator, the work is missing the in the context of RR technique. To cover this gap, we propose a linear regression model in the context of panel surveys/longitudinal studies under the application of the RR technique. We solve all these issues through simulation study.
The Influence of Family Support During Endoscopic Submucosal Dissection (ESD) on Patient’s Anxiety
Authors: Gao Ruo-yu , Gan Ri-Yun , Huang Jia-Lan , Liu Ting-Ting , Wu Ben-Hua , Wang Li-Sheng , Li De-Feng , Yao Jun 
Published: September 2021

Abstract
Background: Psychological problems, such as anxiety and depression, may promote peptic ulcers. The influence of family support on the healing of gastric endoscopic mucosal dissection (ESD)-induced ulcers remains largely undetermined. Objective: In the present study, we aimed to assess the Hospital Anxiety and Depression Scale (HADS) scores and the incidence of post-ESD complications in patients with family support in the care process and those in the non-relative group.Materials and Methods: A total of 191 patients aged between 30 and 70 years who received gastric ESD were evaluated with the Chinese version of HADS. Differences in depression and anxiety between the two groups were compared using the chi-square test and t-test. Multivariable logistic regression models were used to examine whether anxiety and depression were the risk factors for post-ESD complications.Results: The mean values of HADS-A (4.61±2.89 vs. 5.56±3.07, p=0.042) and HADS-D (4.14±3.03 vs. 4.97±2.61, p= 0.048) scores were significantly lower in patients with accompanying relatives compared with those in the non-relative group. Besides, through the pre-ESD and post-ESD self-contrast, the scores of anxiety and depression in the relative-group were 0.57 and 0.56, respectively (p < 0.001), while those in the non-relative group were increased by 1.43 and 1.49, respectively (p < 0.001). Multivariable logistic regression analysis revealed that HADS-A, HADS-D scores, and age were significantly correlated with post-ESD complications (p < 0.05). Conclusions: The occurrence and degree of psychological anxiety and depression in patients who received gastric ESD with accompanying relatives during hospitalization were reduced, and the incidence of post-ESD complications was also decreased.
The continuity of prime numbers can lead to even continuity
Authors: Ling Xie 
Published: September 2021

Abstract
: n continuous prime numbers can combine a group of continuous even numbers. If an adjacent prime number is followed, the even number will continue.For example, if we take prime number 3, we can get even number 6. If we follow an adjacent prime number 5, we can get even numbers by using 3 and 5: 6, 8 and 10.If a group of continuous prime numbers 3,5,7,11,... P, we can get a group of continuous even numbers 6,8,10,12,..., 2n. Then if an adjacent prime number q is followed, the original group of even numbers 6,8,10,12,..., 2n will be finitely extended to 2 (n + 1) or more adjacent even numbers. My purpose is to prove that the continuity of prime numbers will lead to even continuity as long as 2 (n + 1) can be extended.If the continuity of even numbers is discontinuous, it violates the Bertrand Chebyshev theorem of prime numbers.Because there are infinitely many prime numbers: 3, 5, 7, 11,...We can get infinitely many continuous even numbers: 6,8,10,12,...
The Potential Benefits of DEPOC in Mental Health Management During The COVID-19 Pandemic
Authors: Carvey Matthew , Gluschitz Sarah , Hage Robert 
Published: September 2021

Abstract
Background Poor mental health management is a rising concern among healthcare practitioners, as threats of burnout, self-harm, and suicide are gradually becoming issues in the field and have been exacerbated by the COVID-19 pandemic. Acute stress management is increasingly important to prevent the development of post-traumatic stress disorder, and a simplified method for its strategic implementation is essential. Methods Providing a method for healthcare practitioners to manage stressful cases can simultaneously offer support in the critical moments following traumatic events while addressing the origins of burnout. The acronym DEPOC - Debriefing/Defusing, Experience extracted from the event, Personal stress management techniques, Outcome of the event was uncontrollable and Closure/Counsellor - offers a structured framework for healthcare practitioners to address their emotions following distressing incidents. DEPOC is available as a presentation and can be summarized into multilingual poster and pamphlet formats to be posted in high-impact areas. Results DEPOC was presented to nearly 200 medical practitioners and trainees who believed knowledge of the acronym would be beneficial prior to clinical experience, wishing they had known about DEPOC for prior traumatic experiences. The established feedback led us believe we must share the experience and supplementary posters on DEPOC, as it is a vital component in healthcare education regardless of how experienced a healthcare professional may deem themselves in coping. Conclusions The COVID-19 pandemic has left healthcare professionals vulnerable to developing acute stress disorders. DEPOC is a simplified example of a technique used to address stress in healthcare practitioners. By offering a multilingual, standardized method to manage the aftermath of traumatic events, DEPOC addresses this concern.
Three-way Preconcept and Two Forms of Approximation Operators
Authors: Mao Hua , Cheng Yilin , Liu Xiaoqing 
Published: September 2021

Abstract
Three-way decisions, as a better way than two-way decisions, has played an important role in many fields. As an extension of semiconcept, preconcept constitutes a new approach for data analysis. In contrast to preconcept, formal concept or semiconcept are too conservative about dealing with data. Hence, we want to further apply three-way decisions to preconcept. In this work, we introduce three-way preconcept by an example. This new notion combines preconcept with the assistant of three-way decisions. After that, we attain a generalized double Boolean algebra consisting of three-way preconcept. Furthermore, we give two form operators, approximation operators from lattice and set equivalence relation approximation operators, respectively. Finally, we present a conclusion with some summary and future issues that need to be addressed.
The Mechanisms of Yinchensini Decoction in Treating Hepatitis B were Explored by Network Pharmacology and Existing Literatures
Authors: Zhang Xun , Liu Xudong , Liang Xingqiu , Liu Xia , Liang Jian 
Published: September 2021

Abstract
As one of the classic traditional Chinese medicine prescriptions for treating hepatitis B and its related diseases, Yinchensini Decoction has been widely accepted after the thousands of years of spread. However, until now, the underlying molecular mechanisms are remained unclear. Therefore, this study adopts the method of network pharmacology to explore the mechanisms of Yinchensini Decoction in the treatment of hepatitis B. Due to the limitation of experimental conditions, we finally decided to verify the explored mechanisms in the way of existing literatures. The components and related targets of Yinchensini Decoction were screened by the TCMSP database, the targets were converted into gene symols through uniform ID conversion in the Uniprot database. The gene targets of hepatitis B were screened out through the GeneCards database, the gene targets of Yinchensini Decoction for the treatment of hepatitis B were obtained by intersecting the gene targets of Yinchensini Decoction with those of hepatitis B. The STRING database was used to analyze the protein-protein interaction of the intersecting genes, and the metascape database was used to analyze the Gene Ontology and the KEGG pathway of the intersecting genes. Cytoscape3.8.2 was used for mapping various networks and for the specific analysis of various networks. The results show that: quercetin, kaempferol, beta-sitosterol, naringenin, Licochalcone a are the main active ingredients of the Yinchensini Decoction in the treatment of hepatitis B. The main gene targets of these components are TP53, TNF, IFNG, IL6, IL10, MYC, IKBKB, BCL2, STAT1, CHUK. The main mechanisms of these components are MAPK signaling, PI3K signaling, TGFB signaling, JAK-STAT signaling, TLR signaling, RLR signaling, IFN Signaling, chemokine signaling, cell cycle, apoptosis, transcription. In addition, through the analysis of relevant data in the network, about the specific disease of hepatitis B, the herbs in Yinchensini Decoction are ranked according to their importance: yinchen > gancao > ganjiang, fuzi, which are very consistent with the concept of the traditional Chinese medicine theory. Finally, the mechanisms of Yinchensini Decoction through network pharmacology in the treatment of hepatitis B were verified by the relevant literatures. To sum up, the combined application of network pharmacology and relevant literatures validation provides a new practical research strategy for the study of the mechanisms of complex traditional Chinese medicine prescriptions or extremely dangerous substances.
Research on fault diagnosis of planetary gearbox based on Variable Multi-Scale Morphological Filtering and improved Symbol Dynamic Entropy
Authors: Liu Tongtong , Cui Lingli , Zhang Jianyu , Zhang Chao 
Published: September 2021

Abstract
Under complex working conditions with noise interference, the fault feature of planetary gearbox is difficult to be extracted and the fault mode is difficult to be identified. To tackle this problem, the technologies of Variable Multi-scale Morphological Filtering (VMSMF) and Average Multi-scale Double Symbolic Dynamic Entropy (AMDSDE) are proposed in this paper. VMSMF selects Chebyshev Window as the structural element and automatically selects the optimal scale parameters according to the signal characteristics of the planetary gearbox, which improves the filtering accuracy and calculation efficiency. AMDSDE fully considers the correlation between various state modes. Once combined with relevant knowledge of Mathematical statistics, the algorithm can effectively reduce misjudgment. Firstly, the Turn Domain Resampling (TDR) is used to transform the time domain signal of variable speed into the angle domain signal that is not affected by speed change. Secondly, the proposed VMSMF is used to de-noise the vibration signal, and the fault signal with a high signal-to-noise ratio is obtained. Finally, AMDSDE is used to extract the entropy value of the fault signal and judge the fault type. The proposed technology is verified by four kinds of signals collected from the sun gear of the planetary gearbox under non-stationary working conditions.
Cultural Adaptation and Validation of the Malay Chronic Kidney Disease Self-Management Instrument (MCKD-SM)
Authors: Ali Al Sawad Ayat , Lim Soo Kun , Tang Li Yoong , Rashid Aneesa Abdul , Chew Boon-How 
Published: September 2021

Abstract
Background: There is growing evidence that self‐management behaviour can improve outcomes for patients with chronic kidney disease (CKD). However, there are no measures available in Malay to effectively assess self-management of CKD. The aim of this study was to translate, culturally adapt, and validate the Malay Chronic Kidney Disease Self-Management (MCKD-SM) for Malay-speaking health professionals and patients. Methods: This study was carried out in two phases: translation and cultural adaptation, and validation. Instruments were translated from English to Malay then adapted and validated in a sample of 337 patients with CKD stages 3-4 attending a nephrology clinic in a tertiary hospital in Malaysia. Construct validity was evaluated by exploratory factor analysis. Reliability of the instrument was assessed by internal consistency and test‐retest reliability. The correlations between MCKD-SM and kidney disease knowledge, MCKD-SM and self-efficacy were hypothesised a priori and investigated. Results: The Malay version of the Chronic Kidney Disease Self-Management instrument has 29 items grouped into three factors: “Understanding and Managing my CKD”, “Seeking Support” and “Adherence to Recommended Regimen”. The three factors accounted for 56.3 % of the total variance. Each factor showed acceptable internal reliability with Cronbach’s α from 0.885-0.960. 2-week intra-rater test-retest reliability intraclass correlation coefficient values for all items ranged between 0.938 to 1.000. MCKD-SM scores significantly correlates with kidney disease knowledge (r = 0.366, p < 0.01) and self-efficacy (r = 0.212, p < 0.01).Conclusion: The Malay version of the CKD-SM was found to be a valid and reliable patient‐reported outcome measure of pre-dialysis CKD self-management behaviour in the Malay-speaking population.
Circular RNA EPB41 Expression Predicts Unfavorable Prognoses in NSCLC by Regulating miR-486-3p/eIF5A Axis-Mediated Stemness
Authors: Liu Xiyu , Wu Yue , Lou Yuqing , Jin Mingming , Li Xue , Huang Gang 
Published: September 2021

Abstract
Dysregulation of circular RNAs (circRNAs) has recently been found to play an important role in the progression and development of cancers such as non-small cell lung cancer (NSCLC). Yet the functions of many circRNAs in NSCLC remain unclear. In this study, the circRNA expression profiles in NSCLC tumor tissues and adjacent non-tumorous tissues were detected by high-throughput sequencing. Bioinformatics analyses, the dual-luciferase reporter system, fluorescence in situ hybridization (FISH) and miRNA/mRNA high-throughput sequencing were used to identify circ-EPB41 and its downstream target. The subcutaneous tumor/caudal vein transfer mouse model was used for tumor growth and invasion analysis. The results show that the circ-EPB41 was upregulated in NSCLC tissues and cell lines. Increased circ-EPB41 expression in NSCLC was significantly correlated with malignant characteristics, and positive to post-surgical overall survival of NSCLC patients. Reduced circ-EPB41 expression in NSCLC decreased cell proliferation and invasion in both in vitro and in vivo experiments. The miRNA/mRNA high-throughput sequencing suggested that downregulation of circ-EPB41 promoted microRNA (miR)-486-3p and suppressed eukaryotic translation initiation factor 5A (eIF5A) expression. Luciferase reporter experiments confirmed that miR-486-3p/eIF5A were downstream targets of circ-EPB41. In addition, we also found that downregulation of circ-EPB41 suppressed self-renewal and decreased expression of stemness markers SOX2, OCT-4, Nanog and CD133 by sponging miR-486-3p to enhance eIF5A expression. Taken togeter, these data revealed the important role of circ-EPB41 in regulating NSCLC cell invasion and proliferation by modifying miR-486-3p/eIF5A axis-mediated stemness. We believe our study provides a novel perspective regarding the role of circRNAs in NSCLC progression.