bluuebunny/crossref_metadata_2025_split huggingface dataset:
Composite Measures for Clinical Trials in Psoriatic Arthritis: Testing Pain and Fatigue Modifications in a UK Multicenter Study
Authors: Tillett William , FitzGerald Oliver , Coates Laura C. , Packham Jon , Jadon Deepak R. , Massarotti Marco , Brook Mel , Lane Suzanne , Creamer Paul , Antony Anna , Korendowych Eleanor , Rambojun Adwaye , McHugh Neil J. , Helliwell Philip S. 
Published: March 2021

Objective To test the addition of pain and fatigue to the Composite Psoriatic Arthritis Disease Activity (CPDAI) and the Group for Research and Assessment of Psoriasis and PsA (GRAPPA) Composite Exercise (GRACE) composite measures of psoriatic arthritis (PsA). Methods Clinical and patient-reported outcome measures were assessed in patients with PsA at 3 consecutive follow-up visits over 6 months in a UK multicenter observational study. A pain visual analog scale and Functional Assessment of Chronic Illness Therapy Fatigue scale were added as modifications to the CPDAI and GRACE composite measures. Original and modified versions were tested against the PsA Disease Activity Score (PASDAS) and the Disease Activity Index for PsA (DAPSA). Discrimination between disease states and responsiveness were tested with t-scores, standardized response means (SRMs), and effect sizes. Data were presented to members at the 2020 annual meeting who then voted on the GRAPPArecommended composite and treatment targets for clinical trials. Results One hundred forty-one patients were recruited with a mean PsA disease duration of 6.1 years (range 0–41 yrs). The SRMs for the GRACE and modified GRACE (mGRACE) were 0.67 and 0.64, respectively, and 0.54 and 0.46, respectively, for the CPDAI and modified CPDAI (mCPDAI). The t-scores for the GRACE and mGRACE were unchanged at 7.8 for both, and 6.8 and 7.0 for the CPDAI and mCPDAI, respectively. The PASDAS demonstrated the best responsiveness (SRM 0.84) and discrimination (t-scores 8.3). Most members (82%) agreed the composites should not be modified and 77% voted for the PASDAS as the GRAPPA-recommended composite for clinical trials, with 90% minimal disease activity (MDA) as the target. Conclusion Modifying the CPDAI and GRACE with the addition of pain and fatigue does not enhance responsiveness nor the measures’ ability to detect disease status in terms of requiring treatment escalation. GRAPPA members voted for the PASDAS as the composite measure in clinical trials and MDA as the target.
Pomen varovanja vročih točk geodiverzitete za ohranitev biotske pestrosti na območju Nature 2000 v dolini reke Dragonje
Authors: Čonč Špela 
Published: March 2021

Namen prispevka je na varovanem območju Natura 2000 ovrednotiti geodiverziteto in podati smernice za vključitev v obstoječi sistem naravovarstva. Kot območje preučevanja je bilo izbrano porečje Dragonje. Na podlagi kartografskega gradiva in terenskega dela smo izdelali morfografski zemljevid območja, s pomočjo literature pa prilagodili metodo izračuna indeksa geodiverzitete v geografskih informacijskih sistemih. Končni rezultat je zemljevid indeksa geodiverzitete, na podlagi katerega smo določili vroče točke geodiverzitete. //

The importance of protection of geodiversity hotspots for the conservation of biodiversity in the Natura 2000 area in the Dragonja river valleyThe purpose of the article is to evaluate geodiversity in Natura 2000 protected area and to provide guidelines for inclusion in the existing nature protection system. The Dragonja River basin (SW Slovenia) was selected as a study area. Based on cartographic material and field work we made a morphographic map of the area, and based on the literature we adjusted the method of calculating the geodiversity index in geographic information systems. The final result is a map of the geodiversity index, on the basis of which geodiversity hotspots were determined.
Apiturizem kot presečišče tradicije, zdravilstva in čebelarjeve trajnostne pridobitne dejavnosti // Apitourism as an intersection of tradition, alternative medicine and the beekeeper’s sustainable income-generating activity
Authors: Tišler Vanja , Šuligoj Metod 
Published: March 2021

Apiturizem združuje trajnostni, nišni, dediščinski in zdravstveni turizem. Je nov turistični proizvod in tudi nova raziskovalna tema. V pričujočem prispevku pojasnimo razvoj apiturizma in apiterapije v Sloveniji. Ker je glavna posebnost slovenskega apiturizma certifikat odličnosti, smo s pomočjo intervjujev ugotavljali poglede certificiranih in necertificiranih ponudnikov (čebelarjev) na »izvajanje« apiturizma v praksi. Ugotovili smo, da imajo ponudniki o vključevanju apiturizma v slovensko okolje pozitivno mnenje, kritični pa so do zakonske neurejenosti apiterapije in si od državnih ustanov želijo večjo pomoč pri razvoju in promociji apiturizma. Zaznane so bile tudi razlike med cerificiranimi ponudniki in tistimi, ki certifikata nimajo. //

Apitourism combines sustainable, niche, heritage and health tourism. It is a new tourism product and a new research topic. In this paper we explain the development of apitourism and apitherapy in Slovenia. Since the main feature of Slovenian apitourism is the certificate of excellence, interviews were used to determine the views of certified and non-certified providers (beekeepers) of the business (“implementation” of apitourism in practice). We found out that providers have a positive opinion on the integration of apitourism into the Slovenian environment, but they are critical of the (legal) disorder of apitherapy. They also want more help in the development and promotion of apitourism from state institutions. Differences between certified providers and those who do not have a certificate were identified throughout the research.
Handgrip Force and Maximum Inspiratory and Expiratory Pressures in Critically Ill Patients With a Tracheostomy
Authors: Grigoriadis Konstantinos , Efstathiou Ioannis , Dimitriadis Zacharias , Konstantopoulou Georgia , Grigoriadou Anna , Vasileiadis Georgios , Micha Maria , Tsagaris Iraklis , Armaganidis Apostolos 
Published: March 2021

Background
The association between peripheral striated muscle strength and respiratory muscle strength has been confirmed in a number of disorders. However, this association is unknown in intensive care unit patients with tracheostomies.

Objective
To examine correlations between handgrip force, maximum inspiratory pressure (MIP), and maximum expiratory pressure (MEP) in intensive care unit patients with tracheostomies.

Methods
Twenty patients (7 women, 13 men) with tracheostomies, in the intensive care unit longer than 11 days, in stable condition, with functional limbs, and with Glasgow Coma Scale scores of 15 were recruited. Both MIP and MEP were measured with a membrane manometer; handgrip force was measured with a hydraulic hand dynamometer.

Results
Handgrip force was significantly correlated with MIP (r = 0.45, P = .04) and MEP (r = 0.78, P = .001). Handgrip force was significantly predicted by MIP and MEP when the effect of sex was controlled for (P &lt; .05). However, when MIP and MEP were included as predictors in a regression model, MEP was the only significant predictor (R = 0.80, R2 = 0.63, adjusted R2 = 0.57).

Conclusions
Strength of the hand flexors and strength of the expiratory muscles (abdominal) were significantly correlated in intensive care unit patients. Handgrip strength appears to be an easy, fast way to evaluate expiratory muscle strength by using a simple handhold command without special equipment. A strong handhold may also correspond to strong expiratory muscles. ClinicalTrials.gov: NCT03457376
Spectrum of Anti-NMDA Receptor Antibody Encephalitis
Authors: Datta Amlan Kusum , Pandit Alak , Biswas Samar , Biswas Atanu , Roy Biman Kanti , Gangopaddhyay Goutam 
Published: March 2021

Background:
Anti-N-methyl D-aspartate receptor (anti NMDAR) antibody encephalitis is an immune-mediated entity characterised by a constellation of neuro-psychiatric symptoms.

Objective:
To describe clinical profile and treatment outcomes of patients with anti NMDAR antibody encephalitis.

Settings and Design:
Subjects were selected by screening for all patients satisfying Graus et al.'s criteria for probable anti NMDAR antibody encephalitis, admitted in neurology department of a tertiary care centre in Eastern India.

Materials and Methods:
A prospective, longitudinal study was conducted by identifying 25 patients with anti NMDAR antibodies in CSF and or serum, between September 2018 to February 2020.

Statistical Analysis:
Chi square test was used to compare variables.

Results:
Out of 98 patients screened, 25 subjects (14 females: 11 male) were positive for anti NMDAR autoantibodies, with a mean age of 17 years. 13 subjects belonged to paediatric age group. Most common presenting feature was memory/learning deficit (88%) followed by behavioural abnormalities (84%) and seizures (68%). 11 patients (44%) patients needed escalation to second line therapy, rituximab. Seven (28%) and twelve (48%) patients underwent complete (mRS 0-1) and partial recovery (mRS 2-3) respectively, while 4 (16%) became disabled (mRS 4-5). Mortality was 8%. Paediatric population had a better outcome in terms of disability (p = 0.043).

Conclusion:
Anti NMDAR-Ab encephalitis is the most common cause of antibody positive autoimmune encephalitis worldwide. There are important clinical markers and investigational profiles which carry prognostic significance.
Boulevard Tree Failures During Wind Loading Events
Authors: Johnson Gary , Giblin Chad , Murphy Ryan , North Eric , Rendahl Aaron 
Published: March 2021

AbstractWind loading events vary in their intensity and degree of damage inflicted on urban infrastructure, both green and gray. Damage to urban trees can begin with wind speeds as low as 25 miles per hour, especially when those trees harbor defects that predispose them to structural failures. The tree damage triangle integrates the three main factors that influence tree failures during wind loading events, namely the site characteristics, the (wind) loading event and any defects of the trees in question. The degree of damage that trees experience is generally a function of these factors overlapping each other. For instance, when the potential damage from wind loading events is exacerbated by poor tree architecture and compromised site conditions, the likelihood of significant damage is realized. Two studies on the damage to urban trees and the predictability of damage are reviewed; one study is a long-term gathering of wind loading events and accompanying damage to trees while the other is a case study of one storm in one city on one day. Both studies revealed critical pre-existing conditions that left trees vulnerable to whole tree losses: large trees in limited boulevard widths and severed roots as a result of sidewalk repair.
Root Growth of Accolade™ Elm in Structural Soil Under Porous and Nonporous Asphalt After Twelve Years
Authors: Bassuk Nina , Raffel Gary , Sax Miles Schwartz 
Published: March 2021

AbstractAccolade™ Elm trees were planted in CU Structural Soil®overlaid with porous or nonporous asphalt in 2005. At three separate points (2012, 2015, and 2016) over the last twelve years, root densities were measured with Ground Penetrating Radar to a depth of 30 inches (76.2 cm) beneath the asphalt. Roots under the porous asphalt were more numerous and tended to grow deeper in the structural soil profile. Shoot growth was reduced in trees that grew under the nonporous asphalt beginning in the eighth year after planting. CU Structural Soil®is a viable medium for tree growth and stormwater capture when paved with porous asphalt.
Penilaian Kondisi Jalan Poros Sabbang Selatan Menggunakan Metode Surface Distress Index
Authors: Sari Dewi Artika , Kisman Afdal 
Published: March 2021

Prasarana jalan jika terbebani volume lalu lintas yang tinggi dan berulang-ulang akan menyebabkan terjadinya penurunan kualitas jalan sehingga dapat mempengaruhi keamanan, kenyamanan dan kelancaran dalam berlalu lintas. Untuk menjaga agar tidak terjadi penurunan kondisi khususnya pada jalan poros Kecamatan Sabbang Selatan Kabupaten Luwu Utara tepatnya di jalan Padang Sarre, Buntu Terpedo sampai jalan Dandang sepanjang 4 km perlu adanya penanganan. Maka perlu dilakukan penelitian awal terhadap kondisi permukaan jalan dengan melakukan survei secara visual dengan cara menganalisa kerusakan berdasarkan jenis dantingkat kerusakannya. Tujuan penelitian yaitu menilai kondisi perkerasan danpenanganan sesuai kondisi permukaan jalan. Penelitian ini menggunakan system penilaian kondisi perkerasan menurut Bina Marga dengan perhitungan Surface Distress Index (SDI) untuk jalan beraspal. Dari hasil penelitian di dapatkan penilaian untuk jenis kerusakan permukaan jalan pada ruas kanan yaitu retak pinggir 1,183%, lubang 0,031%, amblas 0,054%, retak kulit buaya 3,271%, retak kotak-kotak 3,222%, tambalan 0,033% dan pengelupasan butir 0,013%. Sedangkan untuk ruas kiri yaitu retak pinggir 0,035%, lubang 0,051%, amblas 0,000%, retak kulit buaya 0,130%, retak kotak-kotak 2,351%, tambalan 0,000% dan pengelupasan butir 0,150%. Kondisi perkerasan jalan yang menjadi objek penelitian sepanjang 4 km yaitu 85% baik, 0% sedang, 15% rusak ringan, 0% rusakberat.Road infrastructure if it is burdened by high and repetitive traffic volumes will cause a decrease in road quality so that it can affect safety, comfort and smoothness in traffic. To prevent deterioration in conditions, especially on the axis road of South Sabbang District, North Luwu Regency, precisely on Padang Sarre road, Buntu Terpedo to Dandang road along 4 km, it needs handling. So it is necessary to conduct an initial research on road surface conditions by conducting a visual survey by analyzing the damage based on the type and level of damage. The research objective was to assess pavement conditions and handling according to road surface conditions. This study uses a pavement condition assessment system according to Bina Marga with the calculation of the Surface Distress Index (SDI) for asphalt roads. From the research results obtained an assessment for the type of road surface damage on the right side, namely edge cracks 1.183%, holes 0.031%, collapse 0.054%, crocodile skin cracks 3.271%, checkered cracks 3.222%, 0.033% patches and 0.013% peeling grains. Whereas for the left section, the edges cracked 0.035%, holes 0.051%, collapsed 0.000%, crocodile skin cracks 0.130%, checkered cracks 2.351%, fillings 0.000% and peeling 0.150%. The condition of the pavement which is the object of the research along 4 km is 85% good, 0% moderate, 15% lightly damaged, 0% heavily damaged.
WUJUD KASIH SAYANG IBU DALAM SENI PATUNG ABSTRAK
Authors: Darma Aulia 
Published: March 2021

Tujuan pembuatan karya akhir ini adalah memvisualisasikan tentang ungkapan kasih sayang seorang ibu dalam wujud karya patung abstrak figuratif dengan teknik cetak (cashting) dengan menggunakan lima tahapan yaitu persiapan, elaborasi, sintesis, realisasi konsep, dan penyelesaian. Setelah melakukan serangkaian proses penciptaan yang panjang maka terciptalah 7 buah patung, diantaranya: ‘’Permulaan’’, ‘’Penantian Yang Panjang’’, ‘’Pengorbanan Ibu’’, ‘’Kasih Sayang’’, ‘’Ungkapan Cinta Ibu’’, ‘’Mendidik’’, dan ‘’Ketulusan’’. Diharapkan karya akhir bermanfaat bagi mahasiswa jurusan seni rupa, sebagai bahan apresiasi dan karya pembanding untuk menciptakan karya patung yang lebih baik di masa yang akan datang. The purpose of this final paper is to visualize the expression of mother's affection in the form of abstract figurative sculpture by printing technique (cashting) by using five stages: preparation, elaboration, synthesis, concept realization, and completion. After performing a series of long creation process then created 7 pieces of sculpture, including: '' Beginnings '', '' Long Waiting '', '' Sacrifice Mother '','' Love '','' Mother Love Expression '' , '' Educating '', and '' Sincerity ''. It is hoped that the final work will be useful for art students, as an appreciation and comparative work to create better sculpture in the future.
PENDALAMAN KARAKTER SISWA-SISWI DALAM EKSTRAKURIKULER TEATER DISMA NEGERI 1 ALALAK MENGGUNAKAN OLAH SUKMA
Authors: Shafwan Rofi 
Published: March 2021

Masalah yang ditemukan dalam Ekstrakuikuler Teater di SMA Negeri 1 Alalak adalah siswa kesulitan dalam mempelajari dan memainkan karakter yang mereka perankan. Ibu Ani Nilawardani, M.Pd selaku penanggung jawab Ekstrakurikuler Teater di SMA Negeri 1 Alalak tidak pernah memberikan arahan untuk pendalaman karakter dalam berteater, beliau pernah tepikir untuk mengajak siswa/siswi ekstrakurikuler Teater olah sukma namun ibu Ani tidak jadi melakukannya karena beliau dan pihak sekolah masih ragu-ragu untuk melakukan olah sukma dengan pemahaman bahwa olah sukma bisa membuat siswa/siswi Ekstrakurikuler Tetaer kesurupan. Penelitian ini bertujuan untuk 1.) Mengetahui proses pelaksanaan pendalaman karakter siswa / siswi ekstrakurikuler Teater di SMA NEGERI 1 Alalak melalui olah sukma, menggunakan metode pendekatan kualitatif. Penelitian ini memberikan pengalaman baru terhadap siswa/siswi untuk bisa belajar bersama dan merasakan bagaimana caranya memainkan karakter, karena karakter sangat penting bagi seorang aktor dalam ber teater untuk menciptakan suasana agar para aktor bisa membawakan perannya senyaman dan bisa sebagus mungkin. Sampel penelitian ini adalah Siswa/siswi yang mengikuti ektrakurikuler teater di SMA Negeri 1 Alalak. The problem found in Theater Extracurricular at Alalak 1 Senior High School is that students have difficulty in learning and playing the characters they play. Mrs. Ani Nilawardani, M.Pd as the person responsible for Theater Extracurricular activities at Alalak 1 Senior High School has never given any direction for character deepening in theater, she had thought to invite extracurricular Theater students, though Ibu Ani did not do it because she and the school still hesitant to do sukma with the understanding that if sukma can make students Extracurricular Theater possessed. This study aims to Determine the process of implementing the deepening of the character of students of extracurricular Theater at Alalak 1 Senior High School through processing the sukma, using a qualitative approach method. This research provides new experiences for students to be able to learn together and feel how to play the character. because the character is very important for an actor in performing theater to create an atmosphere so that the acto performs the role as comfortable and can be as good as possible.
FOTOGRAFI UDARA SEBAGAI SARANA PENUNJANG IKON IDENTITAS KOTA SURABAYA
Authors: Rudhyni Moch Rizky Satrio 
Published: March 2021

Fotografi udara saat ini menjadi senjata pamungkas bagi insan industri kreatif terutama bagi fotografer dalam mengabadikan gambar dengan tujuan tertentu. Sudut pengambilan yang tidak bisa dilihat oleh mata telanjang bisa dihadirkan karena pengambilan gambar dari jarak tinggi tertentu. Ikon identitas kota Surabaya sangat banyak, beberepa ikon kota Surabaya sangat mudah untuk dilihat jika kita berada pada lokasi yang dimaksud, dengan presentasi visual yang berbeda dibandingkan dengan tehnik pengambilan foto didarat, hasil fotografi udara dapat membantu mendatangkan apresiasi oleh penikmat kota Surabaya dari presentasi visual yang dihadirkan. Presentasi dari hasil fotografi udara memiliki nilai estetik dan keunikan tersendiri yang nantinya dapat menarik lebih banyak pengunjung ke kota Surabaya.Aerial photography is currently the ultimate weapon for creative industry people especially for photographers in perpetuating images with a specific purpose. Capture angles that can not be seen by the naked eye can be presented due to shooting from a certain high distance. The identity icon of the city of Surabaya is very much, some Surabaya city icons are very easy to see if we are in the intended location, with different visual presentations compared to the photo shoot technique on the ground, air photography results can help bring appreciation by the audience of Surabaya city from the visual presentation presented. The presentation of aerial photography has its own aesthetic value and uniqueness that will attract more visitors to the city of Surabaya.
Development of an atmospheric chemistry model coupled to the PALM model system 6.0: implementation and first applications
Authors: Khan Basit , Banzhaf Sabine , Chan Edward C. , Forkel Renate , Kanani-Sühring Farah , Ketelsen Klaus , Kurppa Mona , Maronga Björn , Mauder Matthias , Raasch Siegfried , Russo Emmanuele , Schaap Martijn , Sühring Matthias 
Published: March 2021

Abstract. In this article we describe the implementation of an online-coupled gas-phase chemistry model in the turbulence-resolving PALM model system 6.0 (formerly an abbreviation for Parallelized Large-eddy Simulation Model and now an independent name). The new chemistry model is implemented in the PALM model as part of the PALM-4U (PALM for urban applications) components, which are designed for application of the PALM model in the urban environment (Maronga et al., 2020). The latest version of the Kinetic PreProcessor (KPP, 2.2.3) has been utilized for the numerical integration of gas-phase chemical reactions. A number of tropospheric gas-phase chemistry mechanisms of different complexity have been implemented ranging from the photostationary state (PHSTAT) to mechanisms with a strongly simplified volatile organic compound (VOC) chemistry (e.g. the SMOG mechanism from KPP) and the Carbon Bond Mechanism 4 (CBM4; Gery et al., 1989), which includes a more comprehensive, but still simplified VOC chemistry. Further mechanisms can also be easily added by the user. In this work, we provide a detailed description of the chemistry model, its structure and input requirements along with its various features and limitations. A case study is presented to demonstrate the application of the new chemistry model in the urban environment. The computation domain of the case study comprises part of Berlin, Germany. Emissions are considered using street-type-dependent emission factors from traffic sources. Three chemical mechanisms of varying complexity and one no-reaction (passive) case have been applied, and results are compared with observations from two permanent air quality stations in Berlin that fall within the computation domain. Even though the feedback of the model's aerosol concentrations on meteorology is not yet considered in the current version of the model, the results show the importance of online photochemistry and dispersion of air pollutants in the urban boundary layer for high spatial and temporal resolutions. The simulated NOx and O3 species show reasonable agreement with observations. The agreement is better during midday and poorest during the evening transition hours and at night. The CBM4 and SMOG mechanisms show better agreement with observations than the steady-state PHSTAT mechanism.
Viability of Multi-Specialty Dental Center in Bacolod City
Authors: Mendez Jasmine Joyce G. , Mibato Rizalie N.E. 
Published: March 2021

A Multi-Specialty Dental Center (MSDC) is one in which dentists share facilities, administration, income and expenses, support staff, and equipment. It is a single practice entity that provides general dentistry services in collaboration with the provision of one or more dental specialties. Moreover, dentists can specialize in related dental practices or offer a wide range of specialties. This business is relatively stable as it is a growing source of revenue. The primary purpose of a multi-specialty dental clinic is to serve all the needs of patients in one convenient location. Dental specialists can consult with each other and provide tests and radiological exams under one roof. Having a group of experts, dental professionals who can perform together to surpass a patient's dental or aesthetic objectives is an advantage. It is also essential to address a potential challenge within the multi-specialty dental facility.