bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le schizophrène et les trois genres de connaissance
Authors: Lippi Silvia 
Published: July 2021

Y a-t-il un rapport entre l’idée adéquate de Spinoza et la pensée inconsciente chez Freud ? Nous pouvons en effet envisager la fin de l’analyse comme un parcours entre les différentes structures cliniques : névrose, psychose et perversion. Le schizophrène arrive d’emblée à réaliser ce parcours : il traverse la limite entre les structures, en affirmant simultanément leurs différences. Le problème se pose au niveau du lien social, où le schizophrène est blâmé et mis à l’écart : son dire reste en dehors de tout discours établi, écrit Lacan dans L’étourdit . Comment penser alors la force politique du corps sans organes du schizophrène ? Et en quoi relève-t-il, selon notre hypothèse, du troisième genre de connaissance ?
Quand la politique de la ville s’intéresse aux personnes âgées : retour sur des initiatives dans l’agglomération grenobloise
Authors: Pollier Marion 
Published: July 2021

Au local, comment la politique de la ville traite-t-elle les enjeux du vieillissement ? Zoom sur les évolutions à l’œuvre au sein du territoire de la métropole de Grenoble à l’occasion d’un entretien croisé entre Claire Namy, chargée de mission santé à la direction cohésion sociale et politique de la ville de Grenoble-Alpes Métropole, Carole Begou, coordinatrice du contrat local de santé, et Hélène Joseph, chargée de projets sociaux transversaux au CCAS d’Échirolles.
La crise Covid-19 racontée par un médecin de quartier
Authors: Rebeille Borgella Vincent 
Published: July 2021

S’il y a une chose que notre société doit retenir de la pandémie de Covid-19, c’est l’impérieuse nécessité, pour les personnes âgées plus particulièrement, de maintenir du lien physique. C’est le message de Vincent Rebeille, médecin généraliste exerçant depuis trente-sept ans en quartier prioritaire 1 . À travers son témoignage, il dépeint ce qu’il nomme la « fracture humaine » telle qu’il l’a observée en tant que médecin et exhorte à reconsidérer l’usage que nous faisons des technologies de communication.
Excrement, Scale, and the Politics of Neglect: How Life Politics Became Progressive Critique
Authors: Stamatopoulou-Robbins Sophia 
Published: July 2021

Cet article est le fruit d’un terrain de recherche de plusieurs années en Palestine et s’appuie sur trois arguments qui se répondent. Tout d’abord, contrairement à ce qui a été soutenu, l’établissement d’une politique de la mort remonte aux années 1970 et non à celles de la deuxième Intifada (2000-2006). Une politique de la mort est caractérisée par le mépris à l’égard de la vie humaine, notamment par le meurtre et l’utilisation de « boucliers humains ». Le caractère superflu de la vie des Palestiniens apparaît très clairement dans la politique israélienne de gestion des eaux usées et cela, bien avant Oslo. La gestion des excréments s’inscrit dans cette première politique de la mort en exposant les Palestiniens à la toxicité des matières fécales mais aussi parce que cette politique confisque aux communautés locales palestiniennes les outils démocratiques dont ils disposent pour protéger la vie à l’échelle municipale. Enfin, Oslo a modifié la manière dont la gestion des excréments conditionne la vie politique. En effet, l’AP s’est concentrée sur la gestion des eaux usées – à grande échelle et à long terme – tout en mettant l’accent sur la protection des Palestiniens à naître. Ce faisant, elle a maintenu les pouvoirs municipaux impuissants face à la vie biologique. Nous appelons « politique de la négligence » la forme de pouvoir qui en résulte. Nous concluons en suggérant que les efforts des résidents pour rendre la vie plus supportable par rapport à la gestion des excréments sont devenus des pôles critiques et anti-hégémoniques dans la ré-articulation des impératifs nationaux.
Produits de terroir versus produits locaux : une perception différenciée selon deux cultures alimentaires française et québécoise
Authors: Batat Wided 
Published: July 2021

Cet article explore la perception des produits de terroir et locaux à travers une étude qualitative interculturelle effectuée auprès d’un groupe de 30 consommateurs en France et au Québec. Les résultats mettent en avant cinq dimensions expliquant les perceptions différenciées dans les deux cultures : fonctionnelle, identitaire, résistance, émotionnelle et relationnelle. Au-delà de l’intérêt managérial pour les producteurs de bien connaître leurs cibles en identifiant leurs significations culturelles, les résultats de cette étude contribuent à la compréhension des techniques de promotion en adaptant le discours et les offres en matière de produits de terroir/locaux français aux caractéristiques des différentes cultures alimentaires au niveau international.
Epigenetic Analysis of the Chromatin Landscape Identifies a Repertoire of Murine Eosinophil-Specific PU.1-Bound Enhancers
Authors: Felton Jennifer M , Vallabh Sushmitha , Parameswaran Sreeja , Edsall Lee E , Ernst Kevin , Wronowski Benjamin , Malik Astha , Kotliar Michael , Weirauch Matthew T , Barski Artem , Fulkerson Patricia C , Rothenberg Marc E 
Published: July 2021

Abstract
Eosinophils develop in the bone marrow from hematopoietic progenitors into mature cells capable of a plethora of immunomodulatory roles via the choreographed process of eosinophilopoiesis. However, the gene regulatory elements and transcription factors (TFs) orchestrating this process remain largely unknown. The potency and resulting diversity fundamental to an eosinophil’s complex immunomodulatory functions and tissue specialization likely result from dynamic epigenetic regulation of the eosinophil genome, a dynamic eosinophil regulome. In this study, we applied a global approach using broad-range, next-generation sequencing to identify a repertoire of eosinophil-specific enhancers. We identified over 8200 active enhancers located within 1–20 kB of expressed eosinophil genes. TF binding motif analysis revealed PU.1 (Spi1) motif enrichment in eosinophil enhancers, and chromatin immunoprecipitation coupled with massively parallel sequencing confirmed PU.1 binding in likely enhancers of genes highly expressed in eosinophils. A substantial proportion (&gt;25%) of these PU.1-bound enhancers were unique to murine, culture-derived eosinophils when compared among enhancers of highly expressed genes of three closely related myeloid cell subsets (macrophages, neutrophils, and immature granulocytes). Gene ontology analysis of eosinophil-specific, PU.1-bound enhancers revealed enrichment for genes involved in migration, proliferation, degranulation, and survival. Furthermore, eosinophil-specific superenhancers were enriched in genes whose homologs are associated with risk loci for eosinophilia and allergic diseases. Our collective data identify eosinophil-specific enhancers regulating key eosinophil genes through epigenetic mechanisms (H3K27 acetylation) and TF binding (PU.1).
Enhancement of Mast Cell Degranulation Mediated by Purinergic Receptors’ Activation and PI3K Type δ
Authors: Nishi Haruhisa , Niyonsaba François , Pelleg Amir , Schulman Edward S 
Published: July 2021

Abstract
Mast cells express multiple metabotropic purinergic P2Y receptor (P2YR) subtypes. Few studies have evaluated their role in human mast cell (HMC) allergic response as quantified by degranulation induced by cross-linking the high-affinity IgE receptor (FcεRI). We have previously shown that extracellular nucleotides modify the FcεRI activation-dependent degranulation in HMCs derived from human lungs, but the mechanism of this action has not been fully delineated. This study was undertaken to determine the mechanism of activation of P2YRs on the degranulation of HMCs and elucidate the specific postreceptor pathways involved. Sensitized LAD2 cells, a human-derived mast cell line, were subjected to a weak allergic stimulation (WAS) using a low concentration of Ag in the absence and presence of P2YR agonists. Only the metabotropic purinergic P2Y11 receptor (P2Y11R) agonist, adenosine 5'-(3-thio)triphosphate (ATPγS), enhanced WAS-induced degranulation resulting in a net 7-fold increase in release (n = 4; p &lt; 0.01). None of the P2YR agonists tested, including high concentrations of ATPγS (1000 μM), enhanced WAS-induced intracellular Ca2+ mobilization, an essential component of activated FcεRI-induced degranulation. Both a PI3K inhibitor and the relevant gene knockout decreased the ATPγS-induced enhancement. The effect of ATPγS was associated with enhanced phosphorylation of PI3K type δ and protein kinase B, but not the phosphoinositide-dependent kinase-1. The effects of ATPγS were dose dependently inhibited by NF157, a P2Y11R antagonist. To our knowledge, these data indicate for the first time that P2YR is linked to enhancement of allergic degranulation in HMC via the PI3K/protein kinase B pathway.
CD22 Controls Germinal Center B Cell Receptor Signaling, Which Influences Plasma Cell and Memory B Cell Output
Authors: Meyer Sarah J , Steffensen Marie , Acs Andreas , Weisenburger Thomas , Wadewitz Charlotte , Winkler Thomas H , Nitschke Lars 
Published: July 2021

Abstract
Germinal center reactions are established during a thymus-dependent immune response. Germinal center (GC) B cells are rapidly proliferating and undergo somatic hypermutation in Ab genes. This results in the production of high-affinity Abs and establishment of long-lived memory cells. GC B cells show lower BCR-induced signaling when compared with naive B cells, but the functional relevance is not clear. CD22 is a member of the Siglec family and functions as an inhibitory coreceptor on B cells. Interestingly, GC B cells downregulate sialic acid forms that serve as high-affinity ligands for CD22, indicating a role for CD22 ligand binding during GC responses. We studied the role of CD22 in the GC with mixed bone marrow chimeric mice and found a disadvantage of CD22−/− GC B cells during the GC reaction. Mechanistic investigations ruled out defects in dark zone/light zone distribution and affinity maturation. Rather, an increased rate of apoptosis in CD22−/− GC B cells was responsible for the disadvantage, also leading to a lower GC output in plasma cells and memory B cells. CD22−/− GC B cells showed a clearly increased calcium response upon BCR stimulation, which was almost absent in wild-type GC B cells. We conclude that the differential expression of the low-affinity cis CD22 ligands in the GC normally results in a strong attenuation of BCR signaling in GC B cells, probably due to higher CD22-BCR interactions. Therefore, attenuation of BCR signaling by CD22 is involved in GC output and B cell fate.
Associations of Strength and Spatiotemporal Gait Variables With Knee Loading During Gait After Anterior Cruciate Ligament Reconstruction
Authors: Lyle Mark A. , Jensen Jake C. , Hunnicutt Jennifer L. , Brown Jonathan J. , Chambliss Cynthia P. , Newsome Michael A. , Xerogeanes John W. , Tsai Liang-Ching 
Published: July 2021

Context
Altered knee moments are common during gait in patients after anterior cruciate ligament reconstruction (ACLR). Modifiable factors that influence knee moments and are feasible to record in clinical settings such as strength and spatiotemporal values (eg, step length, step width) have not been identified in persons after ACLR.

Objective
To identify strength and spatiotemporal gait values that can predict knee moments in persons after ACLR.

Design
Cross-sectional study.

Setting
Laboratory.

Patients or Other Participants
Twenty-three individuals with ACLR (14.4 ± 17.2 months post-ACLR).

Main Outcome Measure(s)
Peak knee-flexion and -adduction moments were measured while the participants walked at self-selected speeds. Peak isokinetic knee-extensor strength (60°/s) was recorded on a dynamometer, and spatiotemporal gait values were recorded using a pressure walkway. Pearson coefficients were calculated to examine the association of peak knee moments with strength and gait values. Variables correlated with peak knee-flexion and -adduction moments were entered into a stepwise regression model.

Results
Knee-extensor strength and step width were the strongest predictors of knee-flexion moment, accounting for 44% of the variance, whereas stance-phase time and step width were the strongest predictors of knee-adduction moment, explaining 62% of the variance.

Conclusions
The identified spatiotemporal variables could be clinically feasible targets for biofeedback to improve gait after ACLR.
Association of Quality of Life With Moderate-to-Vigorous Physical Activity After Anterior Cruciate Ligament Reconstruction
Authors: Davis-Wilson Hope C. , Thoma Louise M. , Longobardi Lara , Franz Jason R. , Blackburn J. Troy , Hackney A. C. , Pietrosimone Brian 
Published: July 2021

Context
Better knee function is linked to psychological readiness to return to sport after anterior cruciate ligament reconstruction (ACLR). Individuals with ACLR participate in less physical activity than matched uninjured control individuals, yet the association between knee function and physical activity post–ACLR remains unclear.

Objective
To determine the associations between (1) patient-reported knee function measured using the Knee Injury and Osteoarthritis Outcome Score Knee-Related Quality of Life (KOOS-QOL), daily steps, and minutes spent in moderate-to-vigorous physical activity (MVPA) of individuals with ACLR and (2) KOOS-QOL and daily steps and MVPA in individuals with ACLR who presented with (ie, symptomatic) or without (ie, asymptomatic) clinically meaningful knee-related symptoms.

Design
Cross-sectional study.

Setting
Laboratory, free-living conditions.

Patients or Other Participants
A total of 66 individuals with primary unilateral ACLR (36 women, 30 men; age = 22 ± 4 years, height = 1.71 ± 0.1 m, mass = 71.3 ± 12.6 kg, body mass index = 24.2 ± 2.9, time post–ACLR = 28 ± 33 months).

Main Outcome Measure(s)
We collected KOOS data and retrospectively stratified participants into those with (symptomatic group, n = 30) or without (asymptomatic group, n = 36) clinically meaningful knee-related symptoms based on previously defined KOOS cutoffs. We assessed daily steps and MVPA using accelerometers that participants wore on the right hip for 7 days. We conducted linear regressions to determine associations between KOOS-QOL and daily steps and MVPA.

Results
In the entire sample, no associations existed between KOOS-QOL and daily steps (ΔR2 = 0.01, P = .50) or MVPA (ΔR2 = 0.01, P = .36). In the symptomatic group, a greater KOOS-QOL was associated with more time in MVPA (ΔR2 = 0.12, P = .05). In the asymptomatic group, no associations were identified between the KOOS-QOL and daily steps and MVPA.

Conclusions
Individuals with symptoms post–ACLR who spent more time in MVPA reported higher QOL.
Comparison of photorefraction by photoscreener (PlusoptiXA12R) with autorefractometer and cycloplegic retinoscopy in children between 5 and 15 years
Authors: Kripa S. , Prabu V. Rajesh , Ranjini H. , Priyambada Parul , Muralidhar Venu 
Published: July 2021

Aim:
The aim of the study is to compare the photorefraction values by photoscreener (PlusoptiXA12R, PO) with those of autorefractometer (AR) (TOPCON RM800) and cycloplegic retinoscopy (CR) in children.

Methods:
It was an observational cross-sectional analytical study with a sample size of 1000 eyes conducted over a duration of one year in a tertiary eye care center. Children in the age group of 5–15 years with refractive error were screened using photoscreener and AR in noncycloplegic state followed by CR. Interclass correlation and agreement were assessed for measurements taken by all three modalities. Sensitivity and specificity were analyzed. P < 0.05 was taken significant for all statistical tests. Positive likelihood ratio, negative likelihood ratio, positive predictive value, and negative predictive value were statistically analyzed. Receiver operative characteristic curve and area under the curve were plotted.

Results:
Refraction measurements by photoscreener had a strong positive correlation with measurements from CR and AR. Bland-Altman plots depicted the agreement for measurements taken by all three modalities. Sensitivity and specificity of values were high for photoscreener (PlusoptiXA12R) when compared with CR and AR.

Conclusion:
We conclude that photoscreener is a reliable alternative to AR and CR for detection of refractive error in children between 5 and 15 years of age.
Protective effect of pycnogenol against gamma radiation-induced lung injury in rat
Authors: Tan Fazile Cantürk , YAY Arzu Hanım , Yildiz Oğuz Galip , Kaan Dilek 
Published: July 2021

Background and Objective:
The study aims to evaluate the histopathological changes, enzymatic alterations, and DNA damage in rat lungs induced by whole-body gamma irradiation as well as evaluation of the protective effect of pycnogenol.

Materials and Methods:
A hundred adult male rats were equally divided into ten groups including control, four antioxidants, γ-irradiation, four antioxidant + γ-irradiations. This study began the day before radiation treatment and continued for 3 days. The pycnogenol was dissolved 5% dimethyl sulfoxide and then administered orally through a gastric tube at a dose of 37.5 mg/kg, 75 mg/kg, 150 mg/kg, and 300 mg/kg in 24, 48, and 72 h before irradiation. Irradiation was applied with a whole-body irradiation dose of 900 cGy in one fraction. DNA damage, histopathological changes, catalase (CAT), and superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in lung tissue of rats were evaluated 3 days after irradiation.

Results:
CAT and SOD activities were found to be significantly lower in the irradiation group than control (P < 0.001). CAT and SOD activities were higher in the antioxidant + γ-irradiation group than both irradiation and control groups. MDA levels were significantly higher in the irradiation group compared to control (P < 0.001), whereas MDA levels decreased in the antioxidant + γ-irradiation group compared to the irradiation group. The antioxidant groups were significantly increased comet parameters depend on pycnogenol doses compared to control. The antioxidant + γ-irradiation was decreased comet parameter compared to γ-irradiation. As a result of the histopathologically, the antioxidant groups were different than the control group that in the areas of alveolar sacs and connective tissue areas were seen hemorrhage areas similar to the irradiation group.

Conclusion:
We demonstrate that 300 mg/kg of pycnogenol might provide significant protection against deleterious effects from whole-body ionizing radiation on the lung tissue. P300+ γ-ray group was significantly reduced radiation-induced lung injury and was possible to observe significantly preservation.
Apoptotic effects of acacetin in human colon cancer HT-29 and HCT 116 cells
Authors: Aslan Beste Tacal , Ertugrul Baris , Iplik Elif Sinem , Cakmakoglu Bedia 
Published: July 2021

Aim:
Acacetin is a natural flavone compound, which is found in several plants as Robinia pseudoacacia and is demonstrated to have anticancerogenic activities in many types of cancer (e.g., human nonsmall cell lung cancer, and prostate). Colorectal carcinoma (CRC) is one of the serious health problems and is a complex disease. We intended to find a more effective new candidate for the treatment of colon cancer, and hence, we designed this study to investigate the effects of acacetin on CRC (HT-29, HCT 116) in vitro.

Methods:
The study was carried out with the methods that determine for apoptosis (WST-1, Caspase 3/BCA, Annexin V).

Results:
Acacetin showed antitumor and apoptosis-inducing effects in the CRC cell lines.

Conclusions:
Acacetin was effective on CRC cell lines, besides no lethal effect on healthy lung cells (MRC-5).
A Study of Mental Health Status in Relatives of COVID-19 Inpatients in a Tertiary Care Hospital
Authors: Parikh Minakshi Nimesh , Valipay Kartik Srinivasa , Brahmbhatt Mehul , Sorani Pragna , Patel Vrunda Ashok , Khetani Kesha , Patel Nirav , Shah Harvee , Parikh Aatman Nimesh 
Published: July 2021

Introduction:
The global scale of COVID-19 has been enormous, with the disease affecting 20 million people worldwide and resulting in 751,154 deaths by August 14, 2020. An increase in mental health problems is expected with an event of such scale, given past experience with epidemics such as severe acute respiratory syndrome and Ebola, among various vulnerable populations. One such population may be the family members of patients affected with COVID-19.

Methods:
This was a cross-sectional study. Five hundred and forty-one relatives of patients admitted in the COVID-19 wing of a tertiary care hospital were studied. Sociodemographic details were recorded and a Gujarati version of General Health Questionnaire-28 (GHQ-28) was applied. A total score of ≥4 on GHQ-28 was considered indicative of “caseness” or psychiatric morbidity and the population was divided into two groups based on whether the score was <4 or ≥4. The groups were analyzed for any differences with respect to variables like age, gender.

Conclusion:
5.17% of the study population had a GHQ-28 total score of ≥4 indicative of “psychiatric morbidity.” The most common symptoms were fatigue, stress, sleep disturbance, and anxiety. Male gender and advanced age were statistically significantly more likely to have a GHQ-28 total score ≥4.
Incontinencia urinaria en mujeres deportistas de alto nivel.
Authors: Polo Herrera Judith Alexandra 
Published: July 2021

Objetivo: Determinar la prevalencia de incontinencia urinaria (IU) en mujeres jóvenes atletas profesionales, establecer el tipo de IU que se presenta con más frecuencia; determinar los factores de riesgo asociados e identificar el impacto sobre la calidad de vida.
Metodología: Estudio observacional descriptivo tipo corte transversal; se incluyeron a mujeres atletas pertenecientes a la Casa de la Selección Ecuatoriana de Fútbol entre 16 y 35 años que cumplieron los criterios de inclusión, obteniendo una muestra final de 51 participantes.
Se utilizó el Cuestionario Internacional para Incontinencia (ICIQ-SF) y se realizó la prueba de Pad-Test modificado para 1 hora de entrenamiento.
Resultados: El 52,9% (n = 27) auto-reportó haber tenido episodios de poca y/o moderada cantidad de fuga urinaria; el 35,3% (n=18) tuvo un resultado positivo en el Pad-Test. Entre las deportistas que se auto-reportaron continentes el 16,67% (n=4) tuvo pad-test positivo durante el entrenamiento. 51,8% (n=14) de las atletas incontinentes (ICIQ-SF) presentan incontinencia de esfuerzo. No se encontró dependencia entre las variables consideradas como factores de riesgo y episodios de incontinencia. El 70,37 % (n=19) de las deportistas incontinentes consideró que los episodios no afectan en su calidad de vida y un 29,63 % (n=8) los consideró de poca o moderada importancia.
Conclusiones: Existe alta prevalencia de incontinencia urinaria en mujeres deportistas jóvenes, siendo la de esfuerzo la más común. No se evidenció asociación entre las variables planteadas como factores de riesgo e incontinencia en esta población. Los episodios de fuga urinaria no generan impacto sobre su calidad de vida.