bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forward Osmosis Absorption Heat Pumps for Space Conditioning and Graywater Purification: Cycle Development and Working Fluids Selection
Authors: Boman Daniel B. , Hughes Matthew T. , Hughes Kalon M. , Garimella Srinivas 
Published: September 2021

Abstract
A thermodynamic model is developed for a forward osmosis (FO) absorption heat pump capable of purifying graywater and providing year-round space conditioning with low-temperature heat as the primary energy input. The model is applied to 16 potential absorbents, and six are selected for parametric studies on desorber temperature, absorber temperature, condenser temperature, and heat sink temperature to determine the effects on the energy ratio (defined as the ratio of total useful output to total power input) of the cycle and the required graywater flowrate. Experiments are conducted to test the water flux and reverse solute flux in FO for the most promising absorbents. Of the six selected absorbents, four to two salt-organic mixtures and two pure salts appear to have the most promising thermodynamic behavior, while an ionic liquid demonstrates the best FO behavior.
Analysis of Fluid Flow and Heat Transfer in Corrugated Perforated Plate Fin Heat Sinks
Authors: Upalkar Shripad A. , Gakhar Saksham , Krishnan Shankar 
Published: September 2021

Abstract
This paper reports a mathematical model for predicting the fluid and heat flow characteristics of a Z-shaped corrugated perforated plate heat sink. Experiments were carried out to validate overall pressure drop as well as heat transfer predictions. A two-pronged approach was undertaken to design a corrugated perforated fin geometry: (a) macroscopic packaging, where the flow is distributed into conduits before being fed into perforated plates, and (b) microscopic design, where the pores are sized to maximize heat dissipation. A methodology typically used for predicting flow maldistribution is extended for packaging porous perforated plates in the macroscopic approach. An illustrative study is carried that estimates the optimum number of porous perforated plate fins that can be packaged within a given volume under fixed pressure drop constraint. In the microscopic approach, an order of magnitude analysis was carried out to decide the optimum diameter to maximize the heat transfer rate and expression for optimum diameter, and maximum achievable heat flux is proposed. Numerical simulations were carried out by considering full perforated plate porous fin geometry and single-channel geometry, and good agreement in their results was found. Finally, this study elaborates on the importance of achieving uniform flow distribution across the porous perforated plate fins.
Theoretical Investigation on the Heating Performance of a Recuperative Heat Pump Water Heater Using CO2/HCs With Large Temperature Glides in Cold Regions
Authors: Luo Jielin , Wang Qin , Zhao Zhen , Yang Kaiyin , Chen Guangming , Zhang Shaozhi 
Published: September 2021

Abstract
Considering the issues of environmental pollution and energy efficiency, heat pumps are gradually replacing traditional coal combustion for heating at low ambient temperatures. In this paper, eco-friendly CO2/HCs with large temperature glides are applied in a single-stage recuperative heat pump water heater. Its heating performance is theoretically investigated under the working condition of producing circulating hot water in typical winter of northern China, with medium temperature difference between supply/return water and large temperature difference between air inlet and water inlet. Due to its simple structure, low initial investment and high efficiency, its potential for producing circulating hot water is demonstrated. Exergy analyses are conducted to reveal the significant influence of the exergy losses of heat exchanger on system performance. For specified CO2/HC, optimal COP is obtained through global optimization of cycle pressures and mixture concentration. The heating performances of different CO2/HCs are compared, among which CO2/R600 and CO2/R600a behave better. Meanwhile, a typical vapor-injection cycle is used to demonstrate priorities on the heating performance of this recuperative cycle, in which the COP of recuperative cycle using CO2/R600 is more than 3.4% higher than that of the vapor-injection cycle. The results obtained in this paper provide a simple and efficient solution for producing circulating hot water at low ambient temperatures.
Effect of Manufacturing Tolerance in Flow Past a Compressor Blade
Authors: Suriyanarayanan Venkatesh , Rendu Quentin , Vahdati Mehdi , Salles Loic 
Published: September 2021

Abstract
This paper presents the effect of manufacturing tolerance on performance and stability boundaries of a transonic fan using a Reynolds-averaged Navier–Stokes simulation. The effects of tip gap and stagger angle variations were analyzed through a series of single passage and double passage simulation; based on which an optimal arrangement was proposed for random tip gap and random stagger angle variation for a whole annulus rotor. All simulations were carried out using NASA rotor 67 as a test case and AU3D as an in-house computational fluid dynamics solver. Results illustrate that the stagger angle variation mainly affects efficiency and its circumferential variation must be as smooth as possible. Furthermore, the tip gap variation affects the stability boundary as well as performance and its optimal configuration mandates a zigzag arrangement of blades around the annulus, i.e., larger tip gap between two smaller ones.
HVDC Interference on MGL Pipelines
Authors: Sawant Vipul , Garate Shraddha 
Published: September 2021

Abstract
Mahanagar Gas is a City Gas Distribution Company engaged in the distribution of Natural Gas in and around Mumbai City. MGL has around 415 km of commissioned steel pipeline network which is being protected by ICCP. These pipelines are coated with three layer polyethylene coatings. Rectifying the external interferences on pipeline network is a major challenge for pipeline operating personnel in order to maintain safety and integrity of their pipeline. This technical paper is based on study of one of such external interference which posed a threat to MGL’s steel pipeline network.
High Voltage Direct Current (HVDC) is a system for transmission of electricity over long distances. This system uses Direct Current (DC) for bulk transmission of electricity in contrast with the more common Alternating Current (AC) systems. HVDC is considered to be more effective to increase power grid delivery capabilities.
A part of MGL’s pipeline network is currently facing interference due to a HVDC power substation on the outskirts of Mumbai. This substation is being operated by State Government and is affecting around 145 kms of MGL’s steel pipeline network during its monopolar operation for transmission of electricity. This interference is creating multiple anodic and cathodic areas on pipeline network with the help of a high magnitude current entering and exiting from pipeline at multiple locations which are difficult to predict and rectify.
This technical paper will elaborate the concept of HVDC interference on steel pipelines. It will give a brief overview on the methodology adopted for identifying, monitoring and analyzing this interference phenomenon and will comment on the results of this analysis. It will throw light on a variety of technical challenges faced in dealing with this interference while operating a city gas distribution network in particular. And finally, it will discuss about possible remedial measures available and their effectiveness to curb this interference.
Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial
Authors: Gray Alasdair J , Roobottom Carl , Smith Jason E , Goodacre Steve , Oatey Katherine , O’Brien Rachel , Storey Robert F , Curzen Nick , Keating Liza , Kardos Attila , Felmeden Dirk , Lee Robert J , Thokala Praveen , Lewis Steff C , Newby David E 
Published: September 2021

Abstract

Objectives
To establish if the use of early computed tomography (CT) coronary angiography improves one year clinical outcomes in patients presenting to the emergency department with acute chest pain and at intermediate risk of acute coronary syndrome and subsequent clinical events.

Design
Randomised controlled trial.

Setting
37 hospitals in the UK.

Participants
Adults with suspected or a provisional diagnosis of acute coronary syndrome and one or more of previous coronary heart disease, raised levels of cardiac troponin, or abnormal electrocardiogram.

Interventions
Early CT coronary angiography and standard of care compared with standard of care only.

Main outcome measures
Primary endpoint was all cause death or subsequent type 1 or 4b myocardial infarction at one year.

Results
Between 23 March 2015 and 27 June 2019, 1748 participants (mean age 62 years (standard deviation 13), 64% men, mean global registry of acute coronary events (GRACE) score 115 (standard deviation 35)) were randomised to receive early CT coronary angiography (n=877) or standard of care only (n=871). Median time from randomisation to CT coronary angiography was 4.2 (interquartile range 1.6-21.6) hours. The primary endpoint occurred in 51 (5.8%) participants randomised to CT coronary angiography and 53 (6.1%) participants who received standard of care only (adjusted hazard ratio 0.91 (95% confidence interval 0.62 to 1.35), P=0.65). Invasive coronary angiography was performed in 474 (54.0%) participants randomised to CT coronary angiography and 530 (60.8%) participants who received standard of care only (adjusted hazard ratio 0.81 (0.72 to 0.92), P=0.001). There were no overall differences in coronary revascularisation, use of drug treatment for acute coronary syndrome, or subsequent preventive treatments between the two groups. Early CT coronary angiography was associated with a slightly longer time in hospital (median increase 0.21 (95% confidence interval 0.05 to 0.40) days from a median hospital stay of 2.0 to 2.2 days).

Conclusions
In intermediate risk patients with acute chest pain and suspected acute coronary syndrome, early CT coronary angiography did not alter overall coronary therapeutic interventions or one year clinical outcomes, but reduced rates of invasive angiography while modestly increasing length of hospital stay. These findings do not support the routine use of early CT coronary angiography in intermediate risk patients with acute chest pain and suspected acute coronary syndrome.

Trial registration

ISRCTN19102565
,
NCT02284191
.
What are the consequences of caring for older people and what interventions are effective for supporting unpaid carers? A rapid review of systematic reviews
Authors: Spiers Gemma F , Liddle Jennifer , Kunonga Tafadzwa Patience , Whitehead Ishbel Orla , Beyer Fiona , Stow Daniel , Welsh Claire , Ramsay Sheena E , Craig Dawn , Hanratty Barbara 
Published: September 2021

ObjectivesTo identify and map evidence about the consequences of unpaid caring for all carers of older people, and effective interventions to support this carer population.DesignA rapid review of systematic reviews, focused on the consequences for carers of unpaid caring for older people, and interventions to support this heterogeneous group of carers. Reviews of carers of all ages were eligible, with any outcome measures relating to carers’ health, and social and financial well-being. Searches were conducted in MEDLINE, PsycInfo and Epistemonikos (January 2000 to January 2020). Records were screened, and included systematic reviews were quality appraised. Summary data were extracted and a narrative synthesis produced.ResultsTwelve systematic reviews reporting evidence about the consequences of caring for carers (n=6) and assessing the effectiveness of carer interventions (n=6) were included. The review evidence typically focused on mental health outcomes, with little information identified about carers’ physical, social and financial well-being. Clear estimates of the prevalence and severity of carer outcomes, and how these differ between carers and non-carers, were absent. A range of interventions were identified, but there was no strong evidence of effectiveness. In some studies, the choice of outcome measure may underestimate the full impact of an intervention.ConclusionsCurrent evidence fails to fully quantify the impacts that caring for older people has on carers’ health and well-being. Information on social patterning of the consequences of caring is absent. Systematic measurement of a broad range of outcomes, with comparison to the general population, is needed to better understand the true consequences of caring. Classification of unpaid caring as a social determinant of health could be an effective lever to bring greater focus and support to this population. Further work is needed to develop and identify suitable interventions in order to support evidence-based policymaking and practice.
Diagnostic role of urine specific gravity to detect kidney impairment on heat-exposed workers in a shoe factory in Indonesia: a cross-sectional study
Authors: Nainggolan Ginova , Soemarko Dewi , Siregar Parlindungan , Lydia Aida , Bardosono Saptawati , Prijanti Ani Retno , Aulia Diana 
Published: September 2021

ObjectivesGlobally, there are increasing cases of chronic kidney disease of unknown origin among heat-exposed workers. We aimed to see the kidney damages of indoor heat-exposed workers and whether urine specific gravity can predict any kidney damages.DesignA cross-sectional study.SettingA shoe-making factory in West Java, Indonesia.Participants119 subjects were included. Minimum total sample size was 62. Subjects were indoor heat-exposed workers who were exposed to occupational wet-bulb globe temperature (WBGT) of 28°C–30°C for 8 hours daily with 1 hour break, 5 days a week. The inclusion criterion was healthy subjects according to the result from annual medical check-up in 2019. The exclusion criteria were subjects who were taking vitamins and/or supplements that might cause disturbance in urine specific gravity and/or hydration status, pregnant and fasting.Primary and secondary outcome measuresArea under the curve (AUC), sensitivity and specificity of urine specific gravity for the detection of urinary nephrin and urinary kidney injury molecule-1 (KIM-1) were analysed. Estimated glomerular filtration rate (eGFR) and quantitative albuminuria were also measured.ResultsWBGT in the work area of the subject was 28°C–30°C. There were 15 (12.6%) subjects who had eGFR <90 mL/min, but ≥60 mL/min. High serum vasopressin levels were found in 79 subjects with a mean of 6.54 (95% CI 5.94 to 7.14) ng/mL. Most subjects had nephrinuria (87.4%) with preserved renal function (87.4%). Several subjects had elevated urinary KIM-1 (10.9%) and albuminuria (7.6%). AUC of urine specific gravity for increased urinary nephrin was 81.7% (95% CI 68.8% to 94.6%) and statistically significant (p<0.001). Cut-off value of ≥1.018 for urine specific gravity has sensitivity of 71.2% and specificity of 80% for detecting elevation of urinary nephrin levels.ConclusionUrine specific gravity with a cut-off value of ≥1.018 could be used to detect nephrinuria among heat-exposed workers.
Association between systemic sclerosis and peripheral arterial disease: a nationwide observation retrospective claim records cohort study in Taiwan
Authors: Hsieh Ming-Chia , Chen Hsin-Hung , Chou Tzu-Yi , Su Ta-Wei , Lin Cheng-Li , Kao Chia-Hung 
Published: September 2021

ObjectivesRecent studies have proposed associations between systemic sclerosis (SSc) and atherosclerosis and between SSc and cardiovascular disease. However, in Asia, no large-scale studies have focused on the association between peripheral arterial disease (PAD) and SSc.SettingA nationwide observation retrospective cohort study.ParticipantsThe National Health Insurance Research Database was used for selecting patients diagnosed with SSc from 2000 to 2011. Patients diagnosed with PAD before the index date were excluded.Primary and secondary outcome measuresThe SSc cohort comprised 1106 patients with SSc, and the non-SSc cohort comprised 4424 matched controls. The Cox proportional hazards regression model was used for analysing the adjusted risk of PAD between the case and control patients.ResultsThe SSc cohort exhibited a significantly higher risk (HR=2.15, 95% CI=1.47 to 3.14) of PAD than did the non-SSc cohort. Patients with heart failure exhibited the highest risk of PAD (adjusted HR=2.10, 95% CI=1.20 to 3.70). Moreover, even without any comorbidities, the SSc cohort exhibited a significantly higher risk (adjusted HR=4.17 fold, 95% CI=1.98 to 8.77) of PAD than did the non-SSc cohort.ConclusionSSc is associated with a significantly high risk of PAD. Further studies are required to reduce the PAD risk among patients with SSc.
Relative effectiveness of non-surgical interventions for pain management in knee osteoarthritis: a protocol for a component network meta-analysis of randomised controlled trials
Authors: Thompson Trevor , Ahmed Bawan , Weldon Sharon Marie , Efthimiou Orestis , Stubbs Brendon 
Published: September 2021

IntroductionKnee osteoarthritis is a chronic degenerative disease associated with significant chronic pain, disability and impaired quality of life and is the most common form of osteoarthritis. There is no cure for knee osteoarthritis, and the main therapeutic goals are pain management and improving quality of life. The objective of this study is to evaluate the relative efficacy and acceptability of available interventions using network meta-analysis (NMA) to provide a comprehensive evidence base to inform future treatment guidelines.Methods and analysisA comprehensive literature search of major electronic databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials) and clinical trial registries will identify randomised control trials (RCTs) of interventions listed in NICE guidelines for the treatment of knee osteoarthritis in adults. We will perform an NMA to estimate relative intervention effects across the whole treatment network. If any studies use multicomponent intervention packages, we will employ a component NMA model to estimate the contribution of individual components. The quality of evidence will be assessed using the Confidence in Network Meta-Analysis approach, which is based on the traditional GRADE framework adapted for NMA. Risk of bias (RoB) will be assessed using the revised Cochrane RoB 2.0 tool for RCTs.Ethics and disseminationThis study does not require ethical approval. Findings will be submitted to a peer-reviewed journal.PROSPERO registration numberCRD42020184192.
Caregiver burden and associated factors among primary caregivers of patients with ALS in home care: a cross-sectional survey study
Authors: Tang Shan , Li Li , Xue Hongxia , Cao Shuyan , Li Chao , Han Kunjing , Wang Binquan 
Published: September 2021

ObjectivesThis study aims to understand the caregiver burden experienced by the primary caregivers of patients with amyotrophic lateral sclerosis (ALS), and to explore the factors influencing caregiver burden.DesignA cross-sectional survey design was used.SettingThis study was conducted with ALS inpatients and follow-up outpatients at the neurology department of a tertiary general hospital in Taiyuan, Shanxi, China and their caregivers.ParticipantsPatients with ALS and their caregivers (N=120 pairs) participated in a face-to-face interview.Primary and secondary outcome measuresPrimary outcome measures included the Zarit Burden Interview scores and personal/role burden scores. There were no secondary outcomes.ResultsMultiple linear and logistic regression analyses were performed to examine the factors influencing burden in ALS patient’s caregivers. Multiple linear regression showed that caregivers with higher Anxiety Index (AI) experienced greater personal (β=0.089, p<0.001), role (β=0.065, p<0.001) and overall (β=0.200, p<0.001) burden. Logistic regression analysis showed that AI (p=0.025; OR 1.351, 95% CI 1.038 to 1.759) and disease knowledge level (p=0.033; OR 0.305, 95% CI 0.107 to 0.593) are the influencing factors of ALS load classification.ConclusionsHigher AI scores were associated with greater caregiver burden. Caregiver burden of caregivers who had no knowledge of the patient’s disease was 0.305 times that of those who had good knowledge. The level of disease knowledge and AI score can serve as key predictors of caregiver burden in ALS.
Is pulmonary embolism recurrence linked with the severity of the first event? A French retrospective cohort study
Authors: Ferrari Emile , Fourrier Etienne , Asarisi Florian , Heme Nathan , Redjimi Nassim , Berkane Nathalie , Labbaoui Mohamed , Breittmayer Jean Philippe , Bun Sok Sithikun , Moceri Pamela , Squara Fabien 
Published: September 2021

ObjectivesSeverity of a first pulmonary embolism (PE) is sometimes proposed as a criterion for prolonging anticoagulant treatment. However, little evidence supports this idea. We attempted to determine the connection between severity of first PE and the risk of recurrence.ParticipantsPatients admitted with PE between 2012 and 2018 and for whom anticoagulant treatment had been discontinued were followed. PEs were classified according to the severity into the following two groups: those with associated cardiac involvement (increased cardiac biomarker(s) and/or echocardiographic right ventricular dysfunction) and those with no cardiac involvement which were classified as non-severe. Recurrence-free survivals were estimated using the Kaplan-Meier method and compared using the log-rank test.Results417 patients with PEs (186 with cardiac involvement) were followed for at least 1 year after discontinuation of treatment with a mean follow-up of: 3.5±1.9 years. 72 patients (17.3%) experienced venous thromboembolism recurrence: 24 (5.8%), 44 (12 %) and 72 (28.3 %) respectively, at 1, 2 and 5 years. In 63 patients (88%), recurrence was a PE. Mean time to onset of recurrence was 24.9±19.9 months. At 5 years, the recurrence rate is higher when the first PE was associated with cardiac involvement p=0.043. In contrast, in patients with provoked PE, the recurrence rate is higher when the first PE event was associated with cardiac involvement: p=0.032. Multivariate analysis demonstrates that PE severity is an independent factor of recurrence (HR 1.634 (1.015–2.632), p=0.043).ConclusionWe report for the first time a possible link between a higher recurrence rate and the severity of the first PE. This result which must be confirmed in a dedicated prospective trial could become an important criterion for the duration of anticoagulant therapy after a PE.Trial registration numberNCT04980924.