bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility
Authors: Franczyk Michael P , Qi Nathan , Stromsdorfer Kelly L , Li Chengcheng , Yamaguchi Shintaro , Itoh Hiroshi , Yoshino Mihoko , Sasaki Yo , Brookheart Rita T , Finck Brian N , DeBosch Brian J , Klein Samuel , Yoshino Jun 
Published: February 2021

Abstract
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme that regulates cellular energy metabolism in many cell types. The major purpose of the present study was to test the hypothesis that NAD+ in white adipose tissue (WAT) is a regulator of whole-body metabolic flexibility in response to changes in insulin sensitivity and with respect to substrate availability and use during feeding and fasting conditions. To this end, we first evaluated the relationship between WAT NAD+ concentration and metabolic flexibility in mice and humans. We found that WAT NAD+ concentration was increased in mice after calorie restriction and exercise, 2 enhancers of metabolic flexibility. Bariatric surgery-induced 20% weight loss increased plasma adiponectin concentration, skeletal muscle insulin sensitivity, and WAT NAD+ concentration in people with obesity. We next analyzed adipocyte-specific nicotinamide phosphoribosyltransferase (Nampt) knockout (ANKO) mice, which have markedly decreased NAD+ concentrations in WAT. ANKO mice oxidized more glucose during the light period and after fasting than control mice. In contrast, the normal postprandial stimulation of glucose oxidation and suppression of fat oxidation were impaired in ANKO mice. Data obtained from RNA-sequencing of WAT suggest that loss of NAMPT increases inflammation, and impairs insulin sensitivity, glucose oxidation, lipolysis, branched-chain amino acid catabolism, and mitochondrial function in WAT, which are features of metabolic inflexibility. These results demonstrate a novel function of WAT NAMPT-mediated NAD+ biosynthesis in regulating whole-body metabolic flexibility, and provide new insights into the role of adipose tissue NAD+ biology in metabolic health.
Do aquatic ectotherms perform better under hypoxia after warm acclimation?
Authors: Collins Michael , Truebano Manuela , Verberk Wilco C. E. P. , Spicer John I. 
Published: February 2021

ABSTRACT
Aquatic animals increasingly encounter environmental hypoxia due to climate-related warming and/or eutrophication. Although acute warming typically reduces performance under hypoxia, the ability of organisms to modulate hypoxic performance via thermal acclimation is less understood. Here, we review the literature and ask whether hypoxic performance of aquatic ectotherms improves following warm acclimation. Interpretation of thermal acclimation effects is limited by reliance on data from experiments that are not designed to directly test for beneficial or detrimental effects on hypoxic performance. Most studies have tested hypoxic responses exclusively at test temperatures matching organisms' acclimation temperatures, precluding the possibility of distinguishing between acclimation and acute thermal effects. Only a few studies have applied appropriate methodology to identify beneficial thermal acclimation effects on hypoxic performance, i.e. acclimation to different temperatures prior to determining hypoxic responses at standardised test temperatures. These studies reveal that acute warming predominantly impairs hypoxic performance, whereas warm acclimation tends to be either beneficial or have no effect. If this generalises, we predict that warm-acclimated individuals in some species should outperform non-acclimated individuals under hypoxia. However, acclimation seems to only partially offset acute warming effects; therefore, aquatic ectotherms will probably display overall reduced hypoxic performance in the long term. Drawing on the appropriate methodology, future studies can quantify the ability of organisms to modulate hypoxic performance via (reversible) thermal acclimation and unravel the underlying mechanisms. Testing whether developmental acclimation and multigenerational effects allow for a more complete compensation is essential to allow us to predict species' resilience to chronically warmer, hypoxic environments.
Level of development, foreign direct investment and domestic investment in food manufacturing
Authors: Djokoto Justice Gameli 
Published: February 2021

Background:Whilst the literature on the complementarity and substitutability of foreign direct investment (FDI) on domestic investment (DI) is not uncommon, the facet of food manufacturing is non-existent. This paper fills this void by investigating the effect of FDI on DI in the food manufacturing sector for developing, economies in transition and developed countries.Methods:Using an unbalanced panel data of 49 countries from 1993 to 2016, from FAOSTAT, estimated by the system generalised method of moments (GMM), the Wald statistics for the short and long-run effects of FDI on DI were computed for the development groups.Results:Developed economies experienced a crowd-out effect of FDI on DI in the short run, whilst the others experienced no significant effect. In the case of the long run, food manufacturing sectors of all three development groups exhibited a crowd-out effect. The effect in the long run for all development groups together is a crowd-in. Analysing all country groups together could mask the results of the various country groups.Conclusions:A review of investment policies to priorities FDI entry mode that favour domestic investment is needed. Improvement of the investment regulatory and administrative efficiency among others are recommended.
Prior Beliefs and Ambiguity Attitudes in Decision from Experience
Authors: Aydogan Ilke 
Published: February 2021

Prior beliefs and their updating play a crucial role in decisions under uncertainty, and theories about them have been well established in classical Bayesianism. Yet, they are almost absent for ambiguous decisions from experience. This paper proposes a new decision model that incorporates the role of prior beliefs, beyond the role of ambiguity attitudes, into the analysis of such decisions. Hence, it connects ambiguity theories, popular in economics, with decision from experience, popular (mostly) in psychology, to the benefit of both. A reanalysis of some existing data sets from the literature on decisions from experience shows that the model that incorporates prior beliefs into the estimation of subjective probabilities outperforms the commonly used model that approximates subjective probabilities with observed relative frequencies. Controlling for subjective priors, we obtain more accurate measurements of ambiguity attitudes, and thus a new explanation of the gap between decision from description and decision from experience. This paper was accepted by Manel Baucells, decision analysis.
Ensaio Visual - Memórias do microespaço
Authors: Azambuja Patrícia 
Published: February 2021

Se o "olhar colonial" tem poder de restringir o pensamento, seria a "decolonialidade" o exercício de liberdade que tanto imaginei para a minha própria existência? Talvez eu não seja a responsável pela criação do imaginário que permeia o meu cotidiano até então; mas seria possível tornar-me detentora dessa porção imaginativa da vida a partir de agora? Se o medo da estagnação assombra os meus dias, e temer não pode ser a saída, imaginar sim, mobiliza! Construir um repertório a partir das minhas próprias experiências, ou através do conhecimento de quem sou de fato, é resgate. É libertário e possível.
CORPO, TEMA E O ESPAÇO DA SALA DE AULA
Authors: Rocha de Lima Hélio Junior 
Published: February 2021

Esta pesquisa visa instigar reflexões sobre experiências no âmbito da sala de aula nos estudos e dinâmicas do componente curricular corpo, movimento e ludicidade do curso de pedagogia. Considerando o caráter intersubjetivo do tema, o professor pesquisador tece observações sobre o desdobramento das aulas com alusão aos estudos introdutórios teórico-práticos do teatro-imagem, proposto por Augusto Boal, e dos movimentos cotidianos e espontâneos elucidados por Rudolf von Laban atravessados por abordagens sobre o tema nos estudos de Paulo Freire, Nickel, Marques e Lima. Verifica-se que a discussão do corpo e movimento, como ação, como atitude no cotidiano, faz emergir questões reveladoras de conhecimento e negação da linguagem corporal em tempos de distanciamento social.
First report of Devonian corals from the Bitlis-Pötürge Massif (SE Turkey): a rare occurrence of corals on the northern margin of Gondwana
Authors: Denayer Julien , Hoşgör Izzet 
Published: February 2021

The Bitlis-Pötürge Massif of SE Turkey is a metamorphic belt separating the Arabian Plate from the Taurides. It includes a non-metamorphic Palaeozoic sequence that contains locally fossiliferous strata. Here is reported for the first time an assemblage of Upper Devonian rugose and tabulate corals from the Meydan Formation, composed of the rugose Frechastraea schafferi (PENECKE), Peneckiella cf. teicherti HILL, Pseudopexiphyllum supradevonicum (PENECKE), and Macgeea desioi VON SCHOUPPÉ, and the tabulate Thamnopora reticulata (DE BLAINVILLE), Alveolites ex. gr. suborbicularis and Scoliopora sp. The rugose corals suggest a Late Frasnian age. The palaeobiogeographic affinities of corals are discussed. The species F. schafferi and the genus Pseudopexiphyllum –so far only reported from Turkey, Iran and Afghanistan– are probably limited to the northern margin of Gondwana and therefore diagnostic for this palaeogeographic area. Until now, the northern margin of Gondwana yielded very few Upper Devonian corals so this occurrence in SE Turkey is particularly important to estimate the relationship between these corals and the ones from the northern margin of the Palaeotethys Ocean.
Maskless fabrication of plasmonic metasurfaces in polymer film using a spatial light modulator
Authors: Bitarafan Mohammad H. , Annurakshita Shambhavee , Toivonen Juha , Bautista Godofredo 
Published: February 2021

We demonstrate a high-speed optical technique to fabricate plasmonic metasurfaces in a polymer film. The technique is based on a programmable spatial light modulator, which is used to spatially control the photoreduction sites of gold ions in a polyvinyl alcohol film doped with a gold precursor. After irradiation, annealing was used to induce the growth of nanoparticles, producing plasmonic microstructures. Using a 473 nm excitation wavelength, microscopic plasmonic gratings, and meta-atom arrays with arbitrary orientations, an effective nanostructure size of

∼

700

n
m

and constituent nanoparticles with average size of

∼

37

n
m

were created. The technique enables a cost-effective and straightforward light-based approach to fabricate plasmonic metasurfaces with tunable properties.
Hair chemicals may increase breast cancer risk: A meta-analysis of 210319 subjects from 14 studies
Authors: Xu Shaohua , Wang Hui , Liu Yeguo , Zhang Chengfeng , Xu Yang , Tian Feng , Mei Lin 
Published: February 2021

BackgroundThe association between personal hair dye use and breast cancer risk is currently debated. The aim of this work is to investigate the association between the use of hair care products and breast cancer risk in women.MethodsBased on the PRISMA-IPD statement, the PubMed, Embase, Cochrane Library, Web of Science, OVID and Scopus databases were used to identify eligible studies published from inception to 22 April 2020. A pooled odds ratio (OR) with a 95% confidential interval (CI) was calculated to assess this correlation via fixed- or random-effect Mantel-Haenszel models using a heterogeneity Chi2test with a significance level of p<0.1. All statistical tests were performed using StataSE software (version 12.0).ResultsThe analyzed data comprised 14 eligible studies with 210319 unique subjects. The pooled results suggested that there was a significant association between the use of hair dyes and breast cancer occurrence (pooled OR = 1.07; 95% CI, 1.01–1.13). Regarding the individual analysis regarding the different types of hair chemicals, permanent hair dye users (pooled OR = 1.08; 95% CI, 1.03–1.14) and rinse users (pooled OR = 1.17; 95% CI, 1.02–1.35) were both found to have a significantly elevated breast cancer risk compared to natural hair subjects, whereas there was an insignificant relationship between the use of semipermanent hair dyes (pooled OR = 1.09; 95% CI, 0.92–1.28) and straighteners (pooled OR = 1.04; 95% CI, 0.96–1.14) and breast cancer risk. No impact on the overall correlation between hair dyes and breast cancer risk due to race (White vs non-White) (pooled OR = 1.05; 95% CI, 0.86–1.29), timing of use (<10 years vs ≥10 years) (pooled OR = 0.96; 95% CI, 0.85–1.08) or dye color (Darker than natural hair vs Lighter than natural hair) (pooled OR = 0.91; 95% CI, 0.62–1.32) was found.ConclusionsChemicals in hair dyes may play a role in breast carcinogenesis and increase breast cancer risk.
Cell-free tumour DNA analysis detects copy number alterations in gastro-oesophageal cancer patients
Authors: Wallander Karin , Eisfeldt Jesper , Lindblad Mats , Nilsson Daniel , Billiau Kenny , Foroughi Hassan , Nordenskjöld Magnus , Liedén Agne , Tham Emma 
Published: February 2021

BackgroundAnalysis of cell-free tumour DNA, a liquid biopsy, is a promising biomarker for cancer. We have performed a proof-of principle study to test the applicability in the clinical setting, analysing copy number alterations (CNAs) in plasma and tumour tissue from 44 patients with gastro-oesophageal cancer.MethodsDNA was isolated from blood plasma and a tissue sample from each patient. Array-CGH was applied to the tissue DNA. The cell-free plasma DNA was sequenced by low-coverage whole-genome sequencing using a clinical pipeline for non-invasive prenatal testing. WISECONDOR and ichorCNA, two bioinformatic tools, were used to process the output data and were compared to each other.ResultsCancer-associated CNAs could be seen in 59% (26/44) of the tissue biopsies. In the plasma samples, a targeted approach analysing 61 regions of special interest in gastro-oesophageal cancer detected cancer-associated CNAs with a z-score >5 in 11 patients. Broadening the analysis to a whole-genome view, 17/44 patients (39%) had cancer-associated CNAs using WISECONDOR and 13 (30%) using ichorCNA. Of the 26 patients with tissue-verified cancer-associated CNAs, 14 (54%) had corresponding CNAs in plasma. Potentially clinically actionable amplifications overlapping the genesVEGFA,EGFRandFGFR2were detected in the plasma from three patients.ConclusionsWe conclude that low-coverage whole-genome sequencing without prior knowledge of the tumour alterations could become a useful tool for cell-free tumour DNA analysis of total CNAs in plasma from patients with gastro-oesophageal cancer.
Disposal practices of expired and unused medications among households in Mwanza, Tanzania
Authors: Marwa Karol Julius , Mcharo Glory , Mwita Stanley , Katabalo Deogratias , Ruganuza Deodatus , Kapesa Anthony 
Published: February 2021

BackgroundThe community practice towards disposal of expired and unused medications in spite of its adverse impact have been widely neglected in many developing countries. The available guidelines in Tanzania focus on the disposal of expired medications and cosmetics in hospitals and community pharmacies only.AimThe aim of this study was to assess the disposal practice of expired and unused medications at household level in Mwanza city, north-western Tanzania.MethodologyThe household based cross-sectional study was conducted among 359 randomly selected household members. Semi-structured questionnaires were used for interview during data collection and while STATA®version 13 was used for analysis.ResultsOut 359 households visited, 252 (70.19%) had medications kept in their houses at the time of data collection. Among them, 10 (4.0%) households had kept medications at their houses because they were still continuing with treatment while 242 (96.0%) kept unused medications which were supposed to be discarded. The main reason for keeping unused or expired medications at home was uncompleted course of treatment (199 (82.20%) after feeling that they had recovered from illness. The main reason for discarding medications were recovering from illness (141(48.7%) and expiry (136 (46.9%). The major discarding practices for medications were disposing into domestic trashes (219 (75.5%) and pit latrines (45 (15.5%). Majority of respondents (273 (76%) were aware that improper disposal of expired medications are detrimental to human health and environment in general.ConclusionImproper disposal of unused and expired medications at household level was a common practice in the study area. Tailor-made interventions by the Food and Drugs Authority (FDA) and other national as well as local stake holders are urgently needed to address the situation.
Prevalence and associated factors of impaired renal function and albuminuria among adult patients admitted to a hospital in Northeast Ethiopia
Authors: Fiseha Temesgen , Ahmed Ermiyas , Chalie Semagn , Gebreweld Angesom 
Published: February 2021

Background
Chronic kidney disease (CKD) is increasingly common in hospitalized patients and is associated with increased risk for in-hospital morbidity and mortality. However, data regarding the prevalence of CKD in the African hospitalized patient population are limited. We therefore examined the prevalence and associated factors of impaired renal function and albuminuria among adult patients admitted to the internal medicine wards of a hospital in Northeast Ethiopia.

Methods
A cross-sectional study was conducted from January 1 to April 30, 2020 at the inpatient settings of Dessie referral hospital. Data on demographics and medical history were obtained, and serum creatinine and albuminuria were analyzed. Estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease (MDRD) equation. CKD was defined as impaired eGFR (<60 ml/min/1.73m2) and/or albuminuria. Univariate and multivariable analysis were conducted to determine factors associated with impaired eGFR and albuminuria.

Results
A total of 369 patients were included in this study. The prevalence of impaired eGFR was 19.0% (95%CI: 15.2%–23.2%) and albuminuria was 30.9% (95%CI: 26.3%–35.7%). Overall, 33.9% (95%CI: 29.2%–38.9%) of the patients had some degree of CKD, but only 21.6% (95%CI: 15.1%–29.4%) were aware of their renal disease. In multivariable analysis, older age, a family history of kidney disease, diabetes, hypertension and HIV were independently associated with both impaired eGFR and albuminuria while male gender was independently associated with only albuminuria.

Conclusions
CKD is common in adult patients admitted to the internal medicine wards, but only few patients are aware of their condition. These findings highlight the need for feasible approaches to timely identify kidney disease and raise awareness on the importance of detection and early intervention in the inpatient settings.
Use of advanced PET-volume metrics predicts risk of local recurrence and overall survival in anal cancer
Authors: Susko Matthew S. , Lazar Ann A. , Wang Chia-Ching Jackie , Van Loon Katherine , Feng Mary , Hope Tom A. , Behr Spencer , Anwar Mekhail 
Published: February 2021

Objective
Anal cancer is an uncommon malignancy with the primary treatment for localized disease being concurrent radiation and chemotherapy. Pre-treatment PET/CT is useful for target delineation, with minimal exploration of its use in prognostication. In the post-treatment setting there is growing evidence for advanced PET metrics in assessment of treatment response, and early identification of recurrence essential for successful salvage, however this data is limited to small series.

Methods
Patient with non-metastatic anal cancer from a single institution were retrospectively reviewed for receipt of pre- and post-treatment PET/CTs. PET data was co-registered with radiation therapy planning CT scans for precise longitudinal assessment of advanced PET metrics including SUVmax, metabolic tumor volume (MTV), and total lesion glycolysis (TLG), for assessment with treatment outcomes. Treatment outcomes included local recurrence (LR), progression free survival (PFS), and overall survival (OS), as defined from the completed radiation therapy to the time of the event. Cox proportional hazard modeling with inverse probability weighting (IPW) using the propensity score based on age, BMI, T-stage, and radiation therapy dose were utilized for assessment of these metrics.

Results
From 2008 to 2017 there were 72 patients who had pre-treatment PET/CT, 61 (85%) had a single follow up PET/CT, and 35 (49%) had two follow up PET/CTs. The median clinical follow-up time was 25 months (IQR: 13–52) with a median imaging follow up time of 16 months (IQR: 7–29). On pre-treatment PET/CT higher MTV2.5 and TLG were significantly associated with higher risk of local recurrence (HR 1.11, 95% CI: 1.06–1.16, p<0.001; and HR 1.12, 95% CI: 1.05–1.19, p<0.001), and worse PFS (HR 1.09, 95% CI: 1.04–1.13, p<0.001; and HR 1.09, 95% CI: 1.03–1.12, p = 0.003) and OS (HR 1.09, 95% CI: 1.04–1.16, p = 0.001; and HR 1.11, 95% CI: 1.04–1.20, p = 0.004). IPW-adjusted pre-treatment PET/CT showed higher MTV2.5 (HR 1.09, 95% CI: 1.02–1.17, p = 0.012) and TLG (HR 1.10, 95% CI: 1.00–1.20, p = 0.048) were significantly associated with worse PFS, and post-treatment MTV2.5 was borderline significant (HR 1.16, 95% CI: 1.00–1.35, p = 0.052).

Conclusion
Advanced PET metrics, including higher MTV2.5 and TLG, in the pre-treatment and post-treatment setting are significantly associated with elevated rates of local recurrence, and worse PFS and OS. This adds to the growing body of literature that PET/CT for patient with ASCC should be considered for prognostication, and additionally is a useful tool for consideration of early salvage or clinical trial of adjuvant therapies.
Experiences, distress and burden among neurologists in Norway during the COVID-19 pandemic
Authors: Kristoffersen Espen Saxhaug , Winsvold Bendik Slagsvold , Sandset Else Charlotte , Storstein Anette Margrethe , Faiz Kashif Waqar 
Published: February 2021

Background
The ongoing COVID-19 pandemic has caused rapid changes in the healthcare system. Workforce reorganization, reduced standard of care and a lack of personal protection equipment (PPE) for health care workers were among the concerns raised in the first wave of the pandemic. Our aim was to explore the experiences, distress and burden among Norwegian neurologists during the first weeks of the pandemic.

Methods
Hospital-based neurologists in Norway (n = 400) were invited to a web-based survey in April 2020. The study focused on patient management, organizational changes and personal stress during the first weeks of the pandemic lockdown. Work-home interface stress was assessed by the Cooper Job Stress Questionnaire.

Results
In total, 135 neurologists participated. Seventy-three% experienced a change in their personal work situation, and 67% examined patients with suspected COVID-19 infection and neurological disease. Changed access to resources, and the perception that medical follow-up was unsatisfactory, were associated with a high degree of burden and stress. Neurologists were also worried about the potential lack of PPE and the fear of spreading SARS CoV-2 to close family members. The mean score of work-home interface stress was 2.8 with no significant differences between gender or specialist status. Reduced standard of care was reported for all neurological conditions, and in particular for non-emergency treatments.

Conclusion
The vast majority of neurologists in Norway experienced a change in their personal work situation during the first phase of the pandemic. The fear of becoming infected and ill was not a major contributor to burden and stress.