bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategy to Avoid Anastomotic Leakage in Laparoscopic Colorectal Resection Using the Indocyanine Green Fluorescence System
Authors: Higashijima Jun , Yoshimoto Toshiaki , Eto Shohei , Kashihara Hideya , Takasu Chie , Nishi Masaaki , Tokunaga Takuya , Yoshikawa Kozo , Shimada Mitsuo 
Published: October 2021

Purpose
Anastomotic leakage (AL) in colorectal resections is often caused by insufficient blood flow to the stump. Injecting indocyanine green can help detect blood flow intraoperatively. In this study, we evaluated our original strategy using an indocyanine green fluorescence system to avoid AL.

Methods
We retrospectively evaluated 79 patients who underwent laparoscopic colorectal resection for colon cancer using a double-stapling technique. Blood flow in oral stumps was evaluated by measuring indocyanine green fluorescence time (FT). We investigated AL cases in detail and analyzed correlations between FT and risk factors for AL.

Results
Of the 79 patients, 7 (8.9%) developed AL. We divided patients by FTs: &gt;60 seconds, 50 to 60 seconds, and &lt;50 seconds. The AL rates were FT &gt;60 seconds, 60%; FT 50 to 60 seconds, 10.3%; and FT &lt;50 seconds, 2.2%. The AL rate of high-risk cases (with more than 2 risk factors) were calculated and we made our original strategy to avoid AL as the following. Further resection or diverting stomas were needed by the FT &gt;60 seconds group, and by members of the FT 50 to 60 seconds group with ≥3 risk factors. The FT &lt;60 seconds group needed no additional management.

Conclusions
Patients with delayed FT (&gt;60 seconds, or 50–60 seconds with ≥3 risk factors) may need revision of the anastomosis (diverting stoma or additional resection) to avoid AL. Our original strategy may contribute to reduce AL in colorectal operations.
Does Intracorporeal Anastomosis Decrease the Rate of Surgical Site Infection in Laparoscopic Colon Cancer Surgery?
Authors: Ju Yeon Wook , Ji Woong Bae , Kim Jung Sik , Hong Kwang Dae , Um Jun Won 
Published: October 2021

Objective
This study aimed to compare the surgical site infection (SSI) rates between intracorporeal anastomosis (ICA) and extracorporeal anastomosis (ECA).

Summary of background data
Laparoscopic surgery is recommended for colonic malignancies because of its superior clinical outcomes and comparable oncologic results. Laparoscopic colectomy with ICA has the advantages of incision length and free extraction site choice. However, ICA may be associated with a risk of SSI due to enterotomy inside the abdominal cavity.

Methods
We retrospectively analyzed patients with colon cancer who underwent radical surgery at Korea University Ansan Hospital between January 2017 and June 2020. We compared the SSI rates and other clinical variables between the ICA and ECA groups.

Results
Of the 502 patients who underwent radical surgery for colorectal cancer during the study period, 234 were eligible for inclusion. ECA and ICA were performed in 62.4% and 37.6% of patients, respectively. There were no statistically significant intergroup differences in clinicopathologic variables. The overall SSI rate did not differ between the groups (P = 0.801), but organ/space SSIs were more common in the ICA group than in the ECA group (P = 0.048).

Conclusions
There was no significant difference in overall SSI or anastomotic leakage (AL) rates between the ICA and ECA groups, but the organ/space SSI rate was higher in the ICA group when AL cases were excluded. Further high-quality studies are needed to assess the risk of organ/space SSIs in the ICA after colon cancer surgery.
An empirically based power primer for laboratory aggression research
Authors: Hyatt Courtland S. , Crowe Michael L. , West Samuel J. , Vize Colin E. , Carter Nathan T. , Chester David S. , Miller Joshua D. 
Published: October 2021

AbstractRecent reviews suggest that, like much of the psychological literature, research studies using laboratory aggression paradigms tend to be underpowered to reliably locate commonly observed effect sizes (e.g., r = ~.10–.20, Cohen's d = ~0.20–0.40). In an effort to counter this trend, we provide a “power primer” that laboratory aggression researchers can use as a resource when planning studies using this methodology. Using simulation‐based power analyses and effect size estimates derived from recent literature reviews, we provide sample size recommendations based on type of research question (e.g., main effect vs. two‐way vs. three‐way interactions) and correlations among predictors. Results highlight the large number of participants that must be recruited to reach acceptable (~80%) power, especially for tests of interactions where the recommended sample sizes far exceed those typically employed in this literature. These discrepancies are so substantial that we urge laboratory aggression researchers to consider a moratorium on tests of three‐way interactions. Although our results use estimates from the laboratory aggression literature, we believe they are generalizable to other lines of research using behavioral tasks, as well as psychological science more broadly. We close by offering a series of best practice recommendations and reiterating long‐standing calls for attention to statistical power as a basic element of study planning.
Distributed cooperative neural control of a class of nonlinear multi‐agent systems with unknown time‐varying control coefficient
Authors: Li Xiaojie , Wang Yiguang 
Published: October 2021

SummaryThis article studies the leader–follower cooperative tracking problem of a class of multi‐agent systems with unknown nonlinear dynamics. As the load of the following agent may be changing throughout the whole work process, we consider the control coefficient of the following agent to be time‐varying and nonlinear instead of constant, which is more practical. All agents are connected by the directed communication graph with weighted topology. The followers can have unknown nonidentical nonlinear dynamics and external disturbances. The nonautonomous leader generates the reference trajectory for only part of the followers and others can only receive the information from their neighbors. To achieve the ultimate synchronization of all following agents to the leader, the novel cooperative adaptive control protocols are designed based on the neural approximation and adaptive updating mechanism. A novel singularity‐avoided adaptive updating law is proposed to estimate the control coefficient and compensate for the unknown dynamics online. Lyapunov theory is used to prove the ultimate boundedness of the synchronization tracking error. The correctness and effectiveness of the presented control scheme are demonstrated by two simulations in SISO and MIMO cases, respectively.
Revamping Lithium–Sulfur Batteries for High Cell‐Level Energy Density by Synergistic Utilization of Polysulfide Additives and Artificial Solid‐Electrolyte Interphase Layers
Authors: Wu Peng , Dong Mingxin , Tan Jian , Kang Dongyun Aiden , Yu Choongho 
Published: October 2021

AbstractDespite the high theoretical capacity of lithium–sulfur (Li–S) batteries, a high cell‐level energy density and a long cycling life are barely achieved, mainly due to the large electrolyte‐to‐sulfur ratio, polysulfide (PS) shuttle causing the loss of active sulfur, and the formation of passivation layers on the Li anode. To raise the energy density, holding PS in the cathode has been the most popular approach. Still, it has failed, particularly, when the sulfur loading is high enough to have energy densities similar to those of commercial Li‐ion batteries. Here, a practical approach of achieving high “cell‐level” energy densities is attempted using lithium PS (LPS)‐containing electrolytes instead of a pure electrolyte, reducing the electrolyte‐to‐sulfur ratio and PS diffusion out of the cathode due to concentration differences. Meanwhile, the persistent problems including PS passivation and Li dendrites are suppressed using Li2S‐phobic artificial solid‐electrolyte interphase (A‐SEI) layers on Li metal. The synergistic effects from the LPS additives and A‐SEI result in a superior cell‐level volumetric energy density of 650 Wh L−1 as well as large cumulative energy densities considering cycling life. This approach provides an important stepping stone to realize commercial Li–S batteries rivaling the current Li‐ion batteries.
Loading Single‐Ni Atoms on Assembled Hollow N‐Rich Carbon Plates for Efficient CO2 Electroreduction
Authors: Li Yunxiang , Zhang Song Lin , Cheng Weiren , Chen Ye , Luan Deyan , Gao Shuyan , Lou Xiong Wen (David) 
Published: October 2021

AbstractThe rational design of catalysts’ spatial structure is vitally important to boost catalytic performance through exposing the active sites, enhancing the mass transfer, and confining the reactants. Herein, a dual‐linker zeolitic tetrazolate framework‐engaged strategy is developed to construct assembled hollow plates (AHP) of N‐rich carbon (NC), which is loaded with single‐Ni atoms to form a highly efficient electrocatalyst (designated as Ni‐NC(AHP)). In the carbonization process, the thermally unstable linker (5‐aminotetrazole) serves as the self‐sacrificial template and the other linker (2‐methylimidazole) mainly serves as the carbon and nitrogen source to form hollow NC matrix. The formed Ni‐NC(AHP) catalyst possesses enhanced mesoporosity and more available surface area, thus promoting mass transport and affording abundant accessible single‐Ni sites. These features contribute to remarkable performance for electrochemical CO2 reduction with exceptionally high selectivity of nearly 100% towards CO in a wide potential range and dramatically enhanced CO partial current density.
Digital Light Processing Based Bioprinting with Composable Gradients
Authors: Wang Mian , Li Wanlu , Mille Luis S. , Ching Terry , Luo Zeyu , Tang Guosheng , Garciamendez Carlos Ezio , Lesha Ami , Hashimoto Michinao , Zhang Yu Shrike 
Published: October 2021

AbstractRecapitulation of complex tissues signifies a remarkable challenge and, to date, only a few approaches have emerged that can efficiently reconstruct necessary gradients in 3D constructs. This is true even though mimicry of these gradients is of great importance to establish the functionality of engineered tissues and devices. Here, a composable‐gradient Digital Light Processing (DLP)‐based (bio)printing system is developed, utilizing the unprecedented integration of a microfluidic mixer for the generation of either continual or discrete gradients of desired (bio)inks in real time. Notably, the precisely controlled gradients are composable on‐the‐fly by facilely by adjusting the (bio)ink flow ratios. In addition, this setup is designed in such a way that (bio)ink waste is minimized when exchanging the gradient (bio)inks, further enhancing this time‐ and (bio)ink‐saving strategy. Various planar and 3D structures exhibiting continual gradients of materials, of cell densities, of growth factor concentrations, of hydrogel stiffness, and of porosities in horizontal and/or vertical direction, are exemplified. The composable fabrication of multifunctional gradients strongly supports the potential of the unique bioprinting system in numerous biomedical applications.
Solvent‐Free Mussel‐Inspired Adhesive with Rapid Underwater Curing Capability
Authors: Xia Guozheng , Lin Mei , Jiayu Yi , Jinkang Hu , Bowen Li , Mu Youbing , Wan Xiaobo 
Published: October 2021

AbstractHow to realize fast and strong underwater adhesion has gained much attention recently. Although some mussel‐inspired adhesives that can be cured underwater have been reported, reports on underwater adhesion with both high bonding strength and rapid curing capability are still rare. Furthermore, organic solvents are generally utilized in these adhesives, which are eco‐unfriendly. Here, by taking advantages of the strong underwater adhesion capability of catecholic groups in mussel adhesion proteins (MAPs) and the fast curing capability of polyurethane (PU) prepolymer, a facile yet powerful strategy towards a fast‐curing mussel‐inspired underwater adhesive is reported. The biomimetic adhesive, PUP‐PPG‐DBHP, is a liquid composed of isocyanate‐terminated polypropylene glycol (PPG) and isocyanate‐terminated dopamine bis(hydroxymethyl)propionate (DBHP), which can be directly applied underwater without solvent dilution and reach an average bonding strength around 1.2 MPa at a curing time of only around 30 s on glass substrates. Meanwhile, underwater curing process of PUP‐PPG‐DBHP shows good tolerance toward pH value, ionic strength, and temperature change. Such an engineering adhesive opens an innovative and facile route to a feasible solution for underwater engineering field.
Superior Performance and Stability of 2D Dion–Jacobson Halide Perovskite Photodetectors Operated under Harsh Conditions without Encapsulation
Authors: Lai Zhengxun , Wang Fei , Meng You , Bu Xiuming , Kang Xiaolin , Quan Quan , Wang Wei , Liu Chuntai , Yip SenPo , Ho Johnny C. 
Published: October 2021

AbstractThe practical utilization of electronic and optoelectronic materials such as perovskites not only relies on their good device performance and moisture stability but also requires stability under other operating conditions. Herein, the operational stability of the Dion–Jacobson perovskite (DJP) photodetector under different harsh conditions is carefully studied and compared with that of its widely studied counterpart, i.e., the Ruddlesden–Popper perovskite (RPP) photodetector. The DJP‐based photodetector can maintain its responsivity after storage in humid environments for two months and can ensure stable operation without any photocurrent degradation under continuous light illumination for 20 000 s. Moreover, the DJP film does not exhibit any changes in its absorbance spectrum and surface morphology when it is heated at 100 °C for 18 h, and the film is hardly affected by high‐energy electron beam irradiation. In addition, the mechanical stability of the DJP film is also found to be superior based on the cyclic bending measurements of the fabricated flexible photodetectors. The excellent performance and stability of the DJP‐based photodetector are found to be the result of the elimination of weak van der Waals bonds among the octahedral PbI4 layers of DJP films, which is typically observed in RPP films.
Cytoplasmic NEAT1 Suppresses AML Stem Cell Self‐Renewal and Leukemogenesis through Inactivation of Wnt Signaling
Authors: Yan Huiwen , Wang Zhi , Sun Yao , Hu Liangding , Bu Pengcheng 
Published: October 2021

AbstractAs an essential component of paraspeckles, nuclear paraspeckle assembly transcript 1 (NEAT1) localizes in the nucleus, promoting progression of various malignant solid tumors. Herein, an adverse effect of NEAT1 is reported, showing that the short isoform, NEAT1_1 suppresses acute myeloid leukemia (AML) development. NEAT1_1 is downregulated in leukemia stem cells (LSCs) and its decreased expression correlates with recurrence in AML patients. It is demonstrated that NEAT1_1 suppresses leukemogenesis and LSC function but is dispensable for normal hematopoiesis. Mechanistically, NEAT1_1 is released from the nucleus into the cytoplasm of AML cells, regulated by transcription factor C/EBPβ and nuclear protein NAP1L1. Cytoplasmic NEAT1_1 interacts with Wnt component DVL2 and E3 ubiquitin ligase Trim56, facilitates Trim56‐mediated DVL2 degradation, and thus suppresses Wnt signaling. Collectively, the findings show NEAT1_1 is translocated from the nucleus to the cytoplasm and acts as a tumor suppressor in AML.
Poly (ε‐caprolactone)‐based porous membranes for filtration applications—effect of solvents on precipitation kinetics, performance, and morphology
Authors: Manholi Smitha , Athiyanathil Sujith 
Published: October 2021

AbstractThis work presents fabrication, precipitation kinetics, morphological analysis, and permeation performance of poly (ε‐caprolactone) (PCL) phase inversion membrane, which is a biodegradable polymer. Asymmetric membranes of PCL were fabricated by nonsolvent‐induced phase inversion method using different casting solvents. The effect of casting solvents on the precipitation kinetics, membrane morphology, and performance for filtration applications was studied. Solvents selected based on Hansen solubility parameter value were N,N‐dimethyl formamide, N‐methyl‐2‐pyrrolidone, tetrahydrofuran, triethyl phosphate, 1,4‐dioxane, and acetone. Ternary phase diagram constructed by cloud point measurement described the precipitation kinetics and thermodynamics of the phase inversion. The fabricated membranes were characterized by its thermal, mechanical, and morphology studies. Permeation performance of the prepared membranes was analyzed by studying its equilibrium water content, porosity, and pure water flux. Morphology analysis of membranes showed porous asymmetric structure and spongy to finger like morphology in different solvents. Cloud point measurement showed different precipitation kinetics in each solvent leading to different morphological features to the polymer membranes. Size of the pores of all these membranes determined using the Guerout–Elford–Ferry equation suggests application of these membranes for microfiltration process.
Comparative characterization of gum rosins for their use as sustainable additives in polymeric matrices
Authors: Pavon Cristina , Aldas Miguel , Hernández‐Fernández Joaquín , López‐Martínez Juan 
Published: October 2021

AbstractThere is a growing interest in the use of non‐polluting compounds, which come from renewable sources, and which performance in their scope is equivalent to their synthetic similes. In this work, five types of rosins from different sources were studied, verifying the existence of differences that can be inferred in their subsequent use and application as material additives. For the study, rosins were analyzed using gas‐mass chromatographic techniques, infrared spectrophotometry (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and color characterization. The results showed that the samples are composed of either abietic acid or by its structural isomers in contents higher than 80%. FTIR shows that the main difference in the gum rosins is related to the proclivity to absorb environmental moisture and that this technique is not enough to differentiate them. Moreover, the DSC reveals that the gum rosins present enthalpy relaxation effects due to their manufacturing process. The TGA showed that gum rosins are thermally stable until 200°C, therefore they can be successfully blended with thermoplastic polymers. Finally, the color characterization shows little differences between the samples, being CA the gum rosin with the greatest total color differences.
Self‐sorted Compartmentalization by Simultaneous Use of Natural and Synthetic Amphiphiles
Authors: Park Kyeng Min 
Published: October 2021

AbstractExploiting the orthogonal molecular interactions of natural (phospholipids) and synthetic (mono‐allyloxylated cucurbit[7]uril) amphiphiles to form their own vesicles, the formation of two different types of compartments in a self‐sorted manner mimicking cellular compartments is demonstrated. Even after simultaneous extrusion of both vesicles through small pore membranes, which transformed them into smaller vesicles, both vesicles were not fused but still appeared as independent compartments in sucrose solution. The simultaneous use of natural and synthetic amphiphiles, forming independent compartments, holds great potential for in‐depth investigation of self‐sorted multi‐compartments and their structures as prototype cells.
Highly Diastereoselective Synthesis of Dihydro‐benzoimidazo‐[1,3]‐thiazines via Electro‐oxidative Selenocyclization of Thioallyl Benzoimidazoles
Authors: Halder Atreyee , Mahanty Kingshuk , Maiti Debabrata , De Sarkar Suman 
Published: October 2021

AbstractThe current methodology reveals a green and proficient electro‐oxidative tandem selenocyclization of thioallyl benzoimidazoles manufacturing selenylated dihydro‐benzoimidazo‐thiazine derivatives. Both C−Se and C−N bond formation were achieved via this mild protocol which exhibits good functional group tolerability affording an extensive range of substrate scope up to 96% isolated yields. Complete control over the regioselective formation of the six‐membered heterocycle and stereoselective construction of the contiguous stereocenters was established. The practical electrochemical method operates in an undivided cell at ambient temperature without using any metal and external chemical oxidant.
Per‐ and polyfluoroalkyl substance removal in carbon‐based advanced treatment for potable reuse
Authors: Kumar Pranjali , Rodriguez‐Gonzalez Laura , Salveson Andrew , Ammerman David , Steinle‐Darling Eva 
Published: October 2021

AbstractThe persistence of perfluoroalkyl acids (PFAAs) in wastewater effluent highlights the need for active monitoring and targeted removal of these compounds in potable reuse applications. The City of Altamonte Springs' permanent potable reuse demonstration facility, pureALTA, employs a carbon‐based advanced treatment process using multiple treatment barriers to provide potable water that meets state and federal regulatory requirements and health guidelines for unregulated contaminants. The combination of ozonation, biological activated carbon filtration (BAC), ultrafiltration (UF), granular activated carbon adsorption (GAC), and UV advanced oxidation process (UV AOP) showed complete removal of long‐chain PFAAs (perfluoroalkyl sulfonic acids with ≥6 carbons and perfluoroalkyl carboxylic acids with ≥7 carbons) with federal health guidelines, such as perfluorooctanoic acid and perfluorooctane sulfonate in the advanced treated water while maintaining total organic carbon (TOC) levels below 3 mg/L, the regulatory limit in Florida for indirect potable reuse. Ozone, BAC, and UF showed increases in PFAAs to varying levels based on the transformation of precursors. GAC was the critical process for both TOC and PFAA removal; as anticipated GAC media's age defined the extent of removal of short‐chain PFAAs such as perfluoropentanoic acid and perfluorohexanoic acid. Because of regulatory limits on TOC in Florida potable reuse projects and the absence of regulations on short‐chain PFAAs, TOC continues to dictate GAC media change‐out frequency and operating cost. However, the performance control strategy for GAC at pureALTA may change if stringent limits are set for short‐chain PFAAs in the future. As of May 2021, pureALTA has been in operation for more than 4 years and continues to operate, providing an opportunity for continued research and community engagement.Article Impact StatementThe study represents the first pilot‐scale evaluation of perfluoroalkyl acid removal and correlation to total organic carbon in a carbon‐based advanced treatment process for potable reuse in Florida.
Interaction of remimazolam benzenesulfonate and human serum albumin: a simulated physiological study
Authors: Zhu Yulin , Li Chen , Yu Jingui , Yu Lingzhi , Shao Wei , Shang Shujun 
Published: October 2021

AbstractHere, to elucidate the interaction mechanism and physicochemical properties of remimazolam and human serum albumin interactions, techniques such as fluorescence, circular dichroism (CD) spectroscopy, and isothermal titration calorimetry have been applied for study. The thermodynamic parameters at body temperature (ΔS = −207 J·mol−1·K−1, ΔS = −9.76 × 104 J·mol−1 and ΔG = −3.34 × 104 J·mol−1; 310 K) manifests one strong binding site on the protein, which was modulated by van der Waals forces and hydrogen bonds. What is more, the results of CD, synchronous and three‐dimensional fluorescence showed that remimazolam altered the microenvironment of the protein amino acid residues. A distance of 2.1 nm between the remimazolam and Trp shows the potential for resonance energy transfer. Furthermore, these results potentially provide information for illustrating the pharmacodynamics and toxicodynamics of remimazolam when it is applied clinically.