bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the prefabricated forms of NiTi archwires on orthodontic forces delivered to the mandibular dental arch
Authors: Tachi Akihiko , Tochigi Keisuke , Saze Naomi , Arai Kazuhito 
Published: December 2021

AbstractBackgroundAlthough preformed archwires with a variety of arch forms are currently commercially available, the effects of variation in the shape of these archwires on the orthodontic force at each tooth are not well understood. Therefore, we evaluated the forces delivered by various types of commercially available preformed nickel–titanium alloy (NiTi) archwires in a simulated mandibular dental arch.MethodsSixty-three types of 0.019 × 0.025-inch preformed NiTi archwires from 15 manufactures were selected for analysis. The intercanine width (ICW) and intermolar width (IMW) of each archwire were measured at the mean canine and first molar depths of 30 untreated subjects with normal occlusions. Each archwire was placed in a multi-sensor measurement system simulating the mandibular dental arch of subjects with normal occlusions, and orthodontic forces in the facial-lingual direction at the central incisors, canines, and first molars were measured. Correlations between the ICW, IMW, and ICW/IMW ratio of archwires and the delivered forces were analyzed. The archwires were classified into the following four groups according to the ICW and IMW: Control group, ICW and IMW are within the means ± standard deviations of the normal ranges; Ovoid group, narrow ICW and IMW; Tapered group, narrow ICW; and Square group, narrow IMW. The forces were compared among these groups for each tooth.ResultsSignificant correlations between the measured archwire width and force to each tooth were found, except between IMW and forces at the central incisors and canines. Significant differences in the forces were found among all groups, except between the Ovoid and Tapered groups at all teeth and between the Ovoid/Tapered and Control groups at the first molar. Significantly greater orthodontic forces in the facial direction were delivered at the central incisors by the archwires in the Ovoid and Tapered groups when compared with the archwires in the other groups.ConclusionThese findings suggest that there is a possible risk of a clinically significant level of unfavorable orthodontic force being delivered to the mandibular incisors in labial inclination when using a preformed archwire with an ICW that is narrower than the dental arch.
Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer
Authors: Sabuncu Sinan , Yildirim Adem 
Published: December 2021

AbstractThe use of ultrasound in the clinic has been long established for cancer detection and image-guided tissue biopsies. In addition, ultrasound-based methods have been widely explored to develop more effective cancer therapies such as localized drug delivery, sonodynamic therapy, and focused ultrasound surgery. Stabilized fluorocarbon microbubbles have been in use as contrast agents for ultrasound imaging in the clinic for several decades. It is also known that microbubble cavitation could generate thermal, mechanical, and chemical effects in the tissue to improve ultrasound-based therapies. However, the large size, poor stability, and short-term cavitation activity of microbubbles limit their applications in cancer imaging and therapy. This review will focus on an alternative type of ultrasound responsive material; gas-stabilizing nanoparticles, which can address the limitations of microbubbles with their nanoscale size, robustness, and high cavitation activity. This review will be of interest to researchers who wish to explore new agents to develop improved methods for molecular ultrasound imaging and therapy of cancer.
An experimental investigation for pullout response of a single granular pile anchor in clayey soil
Authors: Vashishtha Hans Raj , Sawant Vishwas A. 
Published: December 2021

AbstractThe granular pile anchor foundation is an effective and economical foundation system to counter the pullout forces exerted in case of transmission towers or foundations in expansive soil. The pullout tests were performed to study the behaviour of a single granular pile anchor in the clayey soil bed. Tests were conducted in a steel tank of 1 ×  1  ×  1 m size with the help of loading frame arrangement. The pullout load required for upward movement equal to 10% diameter was considered as the pullout capacity of the granular pile anchor. In the parametric study, length and diameter of the granular pile anchor were varied to examine their effect. Number of anchor plates was also varied in few tests. The pullout capacity enhanced with an increase in the diameter and length to diameter ratio. The effect of the length to diameter ratio was appreciable up to the value of 10. However, no significant effect was found in the cases of multiple anchor plates. A relationship is proposed to predict normalized pullout capacity.
Choosing what works for whom: towards a better use of mechanistic knowledge in clinical practice
Authors: Alaiti Rafael K. , Saragiotto Bruno T. , Fukusawa Leandro , D.A. Rabelo Nayra , de Oliveira Anamaria S. 
Published: December 2021

Abstract
Background
Clinicians commonly try to use mechanism-based knowledge to make sense of the complexity and uncertainty of chronic pain treatments to create a rationale for their clinical decision-making. Although this seems intuitive, there are some problems with this approach.

Discussion
The widespread use of mechanism-based knowledge in clinical practice can be a source of confusion for clinicians, especially when complex interventions with different proposed mechanisms of action are equally effective. Although the available mechanistic evidence is still of very poor quality, in choosing from various treatment options for people with chronic pain, an approach that correctly incorporates mechanistic reasoning might aid clinical thinking and practice.

Conclusion
By explaining that not all evidence of mechanism is the same and by making a proposal to start using mechanism-based knowledge in clinical practice properly, we hope to help clinicians to incorporate mechanistic reasoning to prioritize and start choosing what may best work for whom.
Hemodynamic analysis for endovascular treatment in small unruptured intracranial aneurysms: a matched comparison study of flow diverter versus LVIS
Authors: Liu Jian , Li Wenqiang , Zhang Yisen , Wang Kun , Yang Xinjian , Zhang Ying 
Published: December 2021

Abstract
Background
We compared the treatment of small unruptured intracranial aneurysms (UIAs) with flow diverter and LVIS-assisted coiling to determine the effects of hemodynamic changes caused by different stent and coil packing in endovascular treatment.

Methods
Fifty-one UIAs in 51 patients treated with pipeline embolization device (PED) were included in this study and defined as the PED group. We matched controls 1:1 and enrolled 51 UIAs who were treated with LVIS stent, which were defined as the LVIS group. Computational fluid dynamics were performed to assess hemodynamic alterations between PED and LVIS. Clinical analysis was also performed between these two groups after the match.

Results
There was no difference in procedural complications between the two groups (P = 0.558). At the first angiographic follow-up, the complete occlusion rate was significantly higher in the LVIS group compared with that in the PED group (98.0% vs. 82.4%, P = 0.027). However, during the further angiographic follow-up, the complete occlusion rate in the PED group achieved 100%, which was higher than that in the LVIS group (98.0%). Compared with the LVIS group after treatment, cases in the PED group showed a higher value of velocity in the aneurysm (0.03 ± 0.09 vs. 0.01 ± 0.01, P = 0.037) and WSS on the aneurysm (2.32 ± 5.40 vs. 0.33 ± 0.47, P = 0.011). Consequently, the reduction ratios of these two parameters also showed statistical differences. These parameters in the LVIS group showed much higher reduction ratios. However, the reduction ratio of the velocity on the neck plane was comparable between two groups.

Conclusions
Both LVIS and PED were safe and effective for the treatment of small UIAs. However, LVIS-assisted coiling produced greater hemodynamic alterations in the aneurysm sac compared with PED. The hemodynamics in the aneurysm neck may be a key factor for aneurysm outcome.
Peer review reduces spin in PCORI research reports
Authors: Mayo-Wilson Evan , Phillips Meredith L. , Connor Avonne E. , Vander Ley Kelly J. , Naaman Kevin , Helfand Mark 
Published: December 2021

Abstract
Background
The Patient-Centered Outcomes Research Institute (PCORI) is obligated to peer review and to post publicly “Final Research Reports” of all funded projects. PCORI peer review emphasizes adherence to PCORI’s Methodology Standards and principles of ethical scientific communication. During the peer review process, reviewers and editors seek to ensure that results are presented objectively and interpreted appropriately, e.g., free of spin.

Methods
Two independent raters assessed PCORI peer review feedback sent to authors. We calculated the proportion of reports in which spin was identified during peer review, and the types of spin identified. We included reports submitted by April 2018 with at least one associated journal article. The same raters then assessed whether authors addressed reviewers’ comments about spin. The raters also assessed whether spin identified during PCORI peer review was present in related journal articles.

Results
We included 64 PCORI-funded projects. Peer reviewers or editors identified spin in 55/64 (86%) submitted research reports. Types of spin included reporting bias (46/55; 84%), inappropriate interpretation (40/55; 73%), inappropriate extrapolation of results (15/55; 27%), and inappropriate attribution of causality (5/55; 9%). Authors addressed comments about spin related to 47/55 (85%) of the reports.
Of 110 associated journal articles, PCORI comments about spin were potentially applicable to 44/110 (40%) articles, of which 27/44 (61%) contained the same spin that was identified in the PCORI research report. The proportion of articles with spin was similar for articles accepted before and after PCORI peer review (63% vs 58%).

Discussion
Just as spin is common in journal articles and press releases, we found that most reports submitted to PCORI included spin. While most spin was mitigated during the funder’s peer review process, we found no evidence that review of PCORI reports influenced spin in journal articles. Funders could explore interventions aimed at reducing spin in published articles of studies they support.
Evaluation of the determinants of food security within the COVID-19 pandemic circumstances- a particular case of Shaanxi, China
Authors: Sarkar Apurbo , Hongyu Wang , Jony Abdul Azim , Das Jiban Chandro , Memon Waqar Hussain , Qian Lu 
Published: December 2021

Abstract
Background
Agricultural food production and distribution industries may play a vital role in determining the current conditions of any country’s food security and sustainable development goals. This paper examined the determinants of food security within three distinct aspects (effective utilization of food, food availability, and food access) within the COVID-19 epidemic situation.

Methods
The qualitative set-up of the study comprised with the identification of drivers by critical analysis of published papers and discussion held with some practitioners. The quantitative data used in this research were collected from a survey covering the agricultural food supply industry in China (Shaanxi Province). The survey was conducted from November to December 2020 and we mainly focus on three aspects of food security (effective utilization of food, food availability, and food access). The core analytical assumptions were made by employing exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and structural equation modeling (SEM).

Results
After analyzing the data collected from 257 agricultural food productions and distribution personnel along with the hypothesis testing, it found that the determinants of the effective utilization of food were positively related to the determinants of food access (β = 0.291, p = 0.029) and food availability (β = 0.298, p = 0.011), and the determinants of food availability were positively related to the food access determinants (β = 0.128, p = 0.002). The association and variance values between food availability and food access were 0.659 and 0.407; the association and variance values between for effective utilization of food and food availability aspects were 0.465 and 0.298, and between effective utilization of food and economy were 0.508 and 0.475.

Conclusion
The study critically evaluated the interconnection among the crucial determinants within the banner of three dimensions, which will act as a major contribution to existing literature. This research will help the government and industry to develop policies and strategies for the successful implementation of all the associated determinants of food security in terms of the epidemic situation.
The effects of straw-returning and inorganic K fertilizer on the carbon–nitrogen balance and reproductive growth of cotton
Authors: HU Wei , YU Chaoran , ZHAO Wenqing , LIU Ruixian , YANG Changqin , ZHOU Zhiguo 
Published: December 2021

Abstract
Background
Many studies have indicated that straw-returning could meet part or even all of the potassium (K) demand for crop growth in the field, but few have compared the effects of crop straw as K source and inorganic K fertilizer on carbon–nitrogen (C–N) balance of cotton and the reproductive growth. To address this, field experiments were conducted using the cotton cultivar, Siza 3, under there treatments (CK as control group one, no crop straw and inorganic K fertilizer were applied; K150 as control group two, 150 kg·ha−1 of K2O was applied; and W9000, 9 000 kg·ha−1 wheat straw, which could provide K2O about 150 kg·ha−1, was incorporated into soil).

Results
Although the final reproductive organ biomass did not differ between W9000 and K150, W9000 had a higher ratio of reproductive organ biomass to total biomass (RRT), suggesting that straw-returning was more conducive to the allocation of biomass to reproductive organs. The theoretical maximum biomass of reproductive organ was higher, but the average and maximum accumulation rates of reproductive organ biomass were 2.8%∼8.3% and 2.5%∼8.2% lower under W9000 than K150. Also, the duration of rapid-accumulation period for reproductive organ biomass (T) was 2.0∼2.8 d longer under W9000 than K150, which was a reason for the higher RRT under W9000. Straw-returning altered the dynamics of leaf K with the growth period, so that W9000 had a more drastic effect on leaf C metabolism than K150. Consequently, lower soluble sugar/free amino acid and C/N ratios were measured under W9000 than K150 at boll-setting (BSS) and boll-opening (BOS) stages. Higher leaf net photosynthetic rate, sucrose phosphate synthase and sucrose synthase activities, and lower acid invertase activity were observed under W9000 than K150 at BSS and BOS and these were more conducive to sucrose accumulation. However, less sucrose was measured under W9000 than K150 at these stages. This should be because straw-returning promoted the assimilate transport capacity when compared with inorganic K fertilizer application, which also explained the higher RRT under W9000 than K150. The lower acid invertase activity under W9000 inhibited the conversion of sucrose to other sugars, hence lower contents of soluble sugar and starch were measured under W9000 than K150.

Conclusion
Under low K condition, crop straw as K source can increase the assimilate transport from source to sink, leading to lower C/N ratio in leaf and higher allocation of biomass to reproductive organs than inorganic K fertilizer.
Evaluation of five algorithms in predicting the sublocalisation of right ventricular outflow tract arrhythmia (RVOTA) when compared to 3D electroanatomical mapping origin
Authors: Prisecaru Raluca Sirbu , Leatu Cristina , Riahi Leila , Costache Victor 
Published: December 2021

Abstract
Purpose
To compare the predictive accuracy of five different algorithms as verified by successful ablation site using 3D electroanatomical non-contact mapping in patients with symptomatic and asymptomatic but high ventricular burden RVOT tachycardias.

Methods
28 Consecutive patients admitted for radiofrequency catheter ablation for symptomatic and asymptomatic, but high ventricular burden idiopathic VPC were recruited for this study. All patients had previous failed or intolerant to beta-blocker and/or at least one class IC anti-arrhythmic agents, and they had normal left ventricular ejection fraction. All patients had documented monomorphic VPC with left bundle branch block morphology and an inferior axis. Concordance of the arrhythmia origin based on ECG algorithm and 3D mapping system site were further evaluated. Of the five algorithms, two algorithms with easy‐applicability and having a memorable design (Dixit and Joshi) and three algorithms with more complex and detailed design (Ito, Zhang, Pytkowski) were selected for comparisons.

Results
Assessment of the diagnostic accuracy showed that each of the five algorithms had only moderate accuracy, and the greatest accuracy was observed in the algorithm proposed by Pytkowski algorithm when assessed by a general cardiologist and Dixit algorithm when evaluated by the electrophysiologist. However, when the algorithms were compared for their accuracy, specificity, sensitivity, no significant differences were found (p = 0.99).

Conclusions
The ECG based algorithms for precise localising RVOTA origin simplify the mapping process, reduce the procedural and fluoroscopic time, and improve clinical outcomes, resulting in greater clinical utility. All the five published 12-lead ECG algorithms for ROTVA differentiation were similar in terms of the diagnostic accuracy, specificity, sensitivity and LRs.
The mildly decreased preoperative bilirubin level is a risk factor for periprosthetic joint infection after total hip and knee arthroplasty
Authors: Fu Jun , Chen Xiyue , Ni Ming , Li Xiang , Hao Libo , Zhang Guoqiang , Chen Jiying 
Published: December 2021

Abstract
Background
Many serologic markers are routinely tested prior to joint arthroplasty, but only few are commonly used to guide surgeons in determining patients most at risk of periprosthetic joint infection (PJI). The objective of this study was to investigate the association between preoperative bilirubin level and PJI after primary hip and knee arthroplasty.

Methods
A retrospective analysis was performed on patients undergoing revision hip and knee arthroplasty at our hospital from January 2016 to December 2019. Laboratory biomarkers were collected before the primary arthroplasty, as well as general patient information. The association between the above serologic markers and postoperative PJI was analyzed.

Results
A total of 72 patients (30 hips/42 knees) were analyzed, including 39 patients with PJI and 33 patients without PJI. Except for total bilirubin (TB) and direct bilirubin (DB), there was no significant difference between the remaining laboratory biomarkers. The preoperative TB and DB in the PJI group were 10.84 ± 0.61 μmol/L and 3.07 ± 0.19 μmol/L, respectively, which were lower than those in the non-PJI group (14.68 ± 0.75 μmol/L and 4.70 ± 0.39 μmol/L, P < 0.001). The area under the curve (AUC) of preoperative TB to predict PJI was 0.755 (P < 0.001, cutoff = 11.55 μmol/L, sensitivity = 66.67%, specificity = 75.76%). Meanwhile, the AUC of preoperative DB was 0.760 (P < 0.001, cutoff = 4.00 μmol/L, sensitivity = 84.62%, specificity = 54.45%).

Conclusions
The serum levels of TB and DB before the primary arthroplasty were lower in PJI patients than in non-PJI patients, and the preoperative values lower than 11.55 μmol/L and 4.00 μmol/L could be considered as a risk factor for postoperative PJI.
Endoscopic retrieval of ingested magnets in children and role of magnetic retrievers
Authors: Elzeneini Wael M. , Cusick Eleri 
Published: December 2021

Abstract
Background
Various high-powered magnetic toy sets constitute a major hazard as the small magnets can be easily swallowed or aspirated by young children. Multiple ingested magnets or the ingestion of a magnet with another metallic object can pose a serious threat as this may lead to bowel perforation, fistulation, intestinal volvulus, bowel obstruction and death.

Main body
Retrieval of ingested magnets from the stomach is routinely performed endoscopically but can become a painstaking quest involving many tedious attempts to secure the magnet(s). Historically, pre-routine endoscopy, magnetic retrievers were used under fluoroscopic control for the removal of metallic objects in the stomach. With the advent of endoscopic retrieval instruments, they fell out of favour and are no longer readily available on the market. Despite this, conventional endoscopic instruments are likely to be less effective than endoscopic-assisted magnetic retrievers due to confounding weak bonds which form between the metal retrieval device and the magnet.
Preoperative testing, and selection of the retrieval instrument with the strongest coupling effect with a magnet, might be beneficial. A simple, endoscopic-assisted magnetic retriever created in theatre can allow for more effective, time-efficient and safe removal of ingested magnets under direct vision.

Conclusion
Urgent removal of multiple ingested magnets or a single ingested magnet coupled with another ingested metallic object should be highlighted. Stricter implementation of a widespread ban over loose magnetic toys is needed. Standardised protocols for the surgical management of ingested magnets should be available in every hospital.
Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): study protocol
Authors: Husain Nusrat , Lovell Karina , Chew-Graham Carolyn A. , Lunat Farah , McPhillips Rebecca , Atif Najia , Aseem Saadia , Begum Jasmin , Bee Penny , Bhui Kamaldeep , Bower Peter , Brugha Traolach , Bhatti Nafeesa , Chaudhry Nasim , Davies Linda , Gire Nadeem , Islam Anharul , Kai Joe , Morrison Jill , Mohmed Naeem , Neelam Jyothi , Rahman Atif , Rathod Shanaya , Siddiqi Najma , Shah Sadia , Shiri Tinevimbo , Waheed Waquas , Mirza Ilyas , Williams Chris , Zaidi Nosheen , Emsley Richard , Morriss Richard 
Published: December 2021

BackgroundIn the UK, postnatal depression is more common in British South Asian women than White Caucasion women. Cognitive–behavioural therapy (CBT) is recommended as a first-line treatment, but there is little evidence for the adaptation of CBT for postnatal depression to ensure its applicability to different ethnic groups.AimsTo evaluate the clinical and cost-effectiveness of a CBT-based positive health programme group intervention in British South Asian women with postnatal depression.MethodWe have designed a multicentre, two-arm, partially nested, randomised controlled trial with 4- and 12-month follow-up, comparing a 12-session group CBT-based intervention (positive health programme) plus treatment as usual with treatment as usual alone, for British South Asian women with postnatal depression. Participants will be recruited from primary care and appropriate community venues in areas of high South Asian density across the UK. It has been estimated that randomising 720 participants (360 into each group) will be sufficient to detect a clinically important difference between a 55% recovery rate in the intervention group and a 40% recovery rate in the treatment-as-usual group. An economic analysis will estimate the cost-effectiveness of the positive health programme. A qualitative process evaluation will explore barriers and enablers to study participation and examine the acceptability and impact of the programme from the perspective of British South Asian women and other key stakeholders.