bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENTOXIFYLLINE ENHANCES IN VITRO T-CELL ANTITUMOR RESPONSE IN BREAST CANCER PATIENTS
Authors: Kuznetsova M. S. , Shevchenko J. A. , Khantakova J. N. , Khristin A. A. , Obleukhova I. A. , Silkov A. N. , Sidorov S. V. , Sennikov S. V. 
Published: October 2021

The NF-κB transcription factor controls the expression of genes responsible for cell cycle, apoptosis, and other immunoregulatory functions. Some nonspecific NF-κB inhibitors were found after discovering the possibility of blocking tumor growth through suppression of NF-κB activity, but their use was complicated by multiple side effects, such as interleukin-1β-related systemic inflammation or non-immunerelated complications, which may be due to inhibition of the p65 NF-κB subunit that plays a central role in organogenesis and inflammation. Inhibition of the c-Rel subunit leads to tumor growth restriction by modulating the T-regulatory cell activity.In 2017, Grinberg-Bleyer and co-authors checked the hypothesis that selective inhibition of the c-Rel subunit can be performed using pentoxifylline and will effectively regulate Treg activity during tumor growth. The authors showed that pentoxphylline, an FDA-approved drug, could indeed induce selective degradation of c-Rel without affecting p65, and suggested that such an effect could be effective in suppressing tumor growth. In this regard, we aimed to investigate in vitro how pentoxifylline affect the functional activity and antitumor cytotoxic potential of T-cells in cancer patients.The objects of the study were peripheral blood mononuclear cells from 25 patients with primary breast cancer (no metastases), 15 patients with metastatic breast cancer, and 25 healthy women without breast pathology. Informed consent was obtained from all donors and patients. The study was approved by the local ethics committee.Here we showed that pentoxifylline treatment in vitro enhances the pro-apoptotic and cytotoxic antitumor response via increasing the expression of TRAIL on T-lymphocytes, mainly in healthy donors and patients with metastatic breast cancer, both on intact T-cells and in response to the cells of the tumor line of human breast carcinoma ZR-75-1. In healthy donors, in the presence of pentoxifylline, a population of highly expressing TRAIL CD4 and CD8 T-cells appears.
REGULATION OF PERIPHERAL B-LYMPHOCYTE DIFFERENTIATION IN RECURRENT MISCARRIAGE
Authors: Malyshkina A. I. , Sotnikova N. Yu. , Kust A. V. , Voronin D. N. 
Published: October 2021

The important role of immune disorders in recurrent miscarriage has been proven. Clarification of the character of B-lymphocyte differentiation and its regulation factors in women with threatened miscarriage and recurrent miscarriage in history is an urgent problem, since it will reveal the immune mechanisms of the pathogenesis of this pathology. Purpose: to establish the features of B-lymphocyte differentiation and factors of its regulation in women with a history of recurrent miscarriage and threatening spontaneous miscarriage at the time of examination.Were examined pregnant women aged 18-40 years at a gestation period of 5-12 weeks. The main group consisted of 60 pregnant women with a threatening spontaneous miscarriage at the time of examination and a history of recurrent miscarriage. As a control, 35 pregnant women with uncomplicated pregnancy were examined. The comparison group consisted of 25 primary pregnant women with threatened spontaneous miscarriage at the time of examination. The material for the study was peripheral venous blood. Subpopulations of B-lymphocytes CD19+, CD19+ IgD+, CD20+IgM+, CD20+IgG+ were determined by flow cytometry; CD19+CD20- CD38+, CD19+CD27- , CD19+CD27+. Serum levels of BAFF and APRIL were assessed by enzyme-linked immunosorbent assay.In the main group, an increase in the proportion of B-cells, CD20+IgM+-lymphocytes and memory cells was recorded in the peripheral blood, along with a decrease in the level of naive cells and plasma cells. In the comparison group, an increase in the proportion of immature IgM+B-cells, circulating memory cells, along with a decrease in naive B-lymphocytes, was registered. in the main group there was a pronounced decrease in the serum BAFF level compared with the control and comparison groups. Analysis of the APRIL content showed a pronounced downward trend in groups with threatened miscarriage relative to healthy pregnant women. Thus, threatening habitual and sporadic miscarriages were associated with a shift in the differentiation of B-lymphocytes towards immature forms and a lack of regulatory influence of BAFF and APRIL, which is reflected in the disruption of B-cell homeostasis and weakening of humoral effector mechanisms at the systemic level. The revealed changes may indicate a single mechanism for the development of a threatening spontaneous miscarriage, the severity of which increases with repeated loss of pregnancy. These changes can lead to an increase in effector cytotoxic mechanisms and an increase in proinflammatory cytokines, which can lead to the development of damaging reactions in the fetoplacental complex, which can be reflected in the clinical picture of the threat of termination of pregnancy.
Diagnostic value of electrocardiographic markers of left bundle branch block in predicting left ventricular reverse remodeling in patients receiving cardiac resynchronization therapy
Authors: Malishevsky L. M. , Kuznetsov V. A. , Todosiychuk V. V. , Shirokov N. E. , Lebedev D. S. 
Published: October 2021

Aim. To analyze the prognostic value of 18 electrocardiographic (ECG) markers of left bundle branch block (LBBB) in predicting left ventricular (LV) reverse remodeling in patients receiving cardiac resynchronization therapy (CRT).Material and methods. The study included 98 patients. Depending on the presence of reverse remodeling during CRT, defined as a decrease in LV endsystolic volume ≥15%, the patients were divided into two groups: non-responders (n=33) and responders (n=65). We selected and analyzed 18 ECG markers included in 9 LBBB criteria.Results. Among the ECG markers significantly associated with reverse remodeling during CRT, the absence of q wave in leads V5-V6 demonstrated the highest sensitivity (92,31%), a negative predictive value (70,59%) and overall accuracy (73,47%). Normal internal deviation interval of the R wave in leads V1-V3 was also associated with the best sensitivity (92.31%), while QS with a positive T in lead aVR — the best specificity (69,7%). Discordant T wave demonstrated the highest positive predictive value (80,33%). Multivariate analysis revealed following ECG signs independently associated with reverse remodeling during CRT: QRS complex duration (odds ratio (OR)=1,022; 95% confidence interval (CI): 1,001-1,043; p=0,040); absence of q wave in leads V5-V6 (OR=4,076; 95% CI: 1,071-15,51; p=0,039); discordant T wave (OR=4,565; 95% CI: 1,708-12,202; p=0,002). These ECG findings were combined into a mathematical model that demonstrated high predictive power (AUC=0,81 [0,722-0,898], p<0,001). Once the cut-off point was determined, a binary variable was obtained that showed higher sensitivity, negative predictive value, and overall accuracy when compared with the actual LBBB criteria. The 5-year survival rate among patients with a model value above the cut-off point was 84,4%, while in patients with a value below the cut-off point — 50% (Log-rank test, p=0,001). To improve usability of the model, a mobile application was developed.Conclusion. For the first time, the diagnostic value of ECG markers of LBBB were analyzed and a mathematical model with ECG signs was proposed to predict reverse remodeling in patients receiving CRT.
IMPACTO DA EXPLORAÇÃO ARTESANAL DE OURO NA SAÚDE DOS GARIMPOS DO DISTRITO DE MANICA – MOÇAMBIQUE
Authors: Raso Edson Fernandes , Pedro Albano Amunacachuma , Gotine Kátia Marisa , Cachepa Moisés Mário , Madacussengua Obete , Jonissene Nicson Nassone 
Published: October 2021

Este pesquisa visa identificar os impactos da exploração artesanal de ouro na saúde dos garimpos do distrito de Manica – Moçambique. Para a sua materialização foi realizada a pesquisa bibliográfica, documental, observação, entrevista e inquérito aos garimpos e aos profissionais de saúde. Os resultados mostraram as doenças que afetam os garimpeiros estão relacionados com as condições em que a actividade mineira é realizada, isto mostra que existe deficiência no uso de equipamento de proteção individual e coletivo. Foram identificadas várias doenças oriundas da atividade garimpo, designadamente infeção das veias respiratórias superiores; feridas incisa; agressões; quedas, lombalgias; dores abdominais, tosse, dores de peito, filarias entre outras. Verificou-se que nas comunidades em estudo a dieta alimentar não é regular, que pode resultar no surgimento de doenças identificadas tais como estresse, depressão, alteração de humor, agressão entre outras. Este estudo evidencia a necessidade de realização de uma exploração sustentável do ouro de modo a garantir a continuidade da actividade de forma saudável sem deixar de lado a educação ambiental que possa promover mudança de comportamento por parte dos garimpeiros.
Palavras-chave: Saúde. Garimpo. Ouro. Manica.
AUTOPLÁGIO NA PESQUISA CIÊNTÍFICA: UM ILÍCITO?
Authors: Leal da Costa Brito Samyr 
Published: October 2021

O autoplágio é desmotivado pela academia, mas existe a dúvida se trata-se de um ilícito ou é apenas uma infração ética. Esse trabalho busca responder à essa dúvida, para tanto utilizou-se de uma pesquisa exploratória, utilizando dos métodos bibliográfico e documental. Analisou-se a relação do autoplágio com o direito autoral, com a boa-fé, com as relações obrigacionais e com o costume jurídico. Chegou-se à conclusão de que a repressão ao autoplágio é um costume jurídico dentro das instituições acadêmicas, bem como, é uma violação à boa-fé e pode configurar-se uma violação da relação obrigacional. Dessa forma, dentro desses contextos o autoplágio pode ser considerado como um ilícito, mas em outras situações, poderá ser apenas uma infração ética.
Manajemen Pemasaran dalam Mempercepat Penyerapan Lulusan dalam Satuan Pendidikan Kejuruan
Authors: Safitri Dinar Ika , Maisyaroh Maisyaroh , Nurabadi Ahmad 
Published: October 2021

Abstract: This study aims to describe the planning, organizing, implementing, and evaluating the marketing of graduates in vocational education units, as well as supporting factors and inhibiting marketing of graduates in vocational education units. This study used a qualitative model with a case study design. Data collection uses interviews, observation, and documentation. In analyzing data using data collection, data reduction, data presentation, and conclusion drawing. The results of the study show that graduates from these schools are absorbed into the world of work even before they graduate from school and have obtained jobs. This is supported by good marketing management starting from planning, organizing, implementing, and evaluating the marketing of graduates. The obstacle is when the parents of students do not want their children to get jobs in long distances.
Abstrak: Penelitian ini bertujuan untuk mendeskripsikan perencanaan, pengorganisasian, pelaksanaan, dan evaluasi pemasaran lulusan dalam satuan pendidikan kejuruan, serta faktor pendukung dan penghambat pemasaran lulusan di satuan pendidikan kejuruan. Penelitian ini menggunakan model kualitatif dengan desain studi kasus. Pengumpulan data menggunakan wawancara, observasi, dan dokumentasi. Dalam menganalisis data menggunakan pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa lulusan dari sekolah tersebut banyak terserap ke dunia kerja bahkan sebelum mereka lulus dari sekolah sudah memperoleh pekerjaan. Hal tersebut didukung dengan manajemen pemasaran yang baik mulai dari perencanaan, pengorganisasian, pelaksanaan, dan evaluasi pemasaran lulusan. Kendalanya adalah ketika orangtua peserta didik tidak ingin anaknya memperoleh pekerjaan dengan jarak yang jauh.
Pengembangan E-Modul Menggunakan Software Flip PDF Profesional Materi Pecahan Kelas V Sekolah Dasar
Authors: Putri Nurfadilla Yustina , Nuraini Ni Luh Sakinah , Ahdhianto Erif 
Published: October 2021

Abstract: Field conditions show that learning fractions in class V requires innovative teaching materials. This study aims to test the validity and practicality of the developed E-Module. The ADDIE model is used in this development. Product validation got the results of 98.68 percent declared valid. Material validation got a percentage result of 83.33 percent declared valid. The practicality test from users (teachers) got a percentage result of 94.23 percent which was declared practical and the practicality test of students got a score of 88.59 percent which was declared practical. So the validation and practicality of the product are declared valid and practical.
Abstrak: Kondisi lapangan menunjukan pembelajaran pecahan di kelas V membutuhkan bahan ajar yang inovatif. Penelitian ini memiliki tujuan untuk menguji kevalidan dan kepraktisan E-Modul yang dikembangkan. Model ADDIE digunakan pada pengembangan ini. Validasi produk mendapat hasil 98,68 persen dinyatakan valid. Validasi materi mendapat hasil persentase sebesar 83,33 persen dinyatakan valid. Uji kepraktisan dari pengguna (guru) mendapat hasil persentase sebesar 94,23 persen dinyatakan praktis dan uji kepraktisan peserta didik mendapatkan nilai sebesar 88,59 persen dinyatakan praktis. Jadi validasi dan uji kepraktisan produk dinyatakan valid dan praktis.
Kontrol Diri Wanita Terhadap Keinginan Merokok
Authors: Siswoyo Anik Sunariyati , Dayati Umi , Ihsan Muh. Ishom 
Published: October 2021

Abstract: Many women found smoking casually smoking in public places and even in the campus canteen. This paper tries to review women's self-control over the desire to smoke, especially for female students majoring in Out-of-school Education in Malang City. The study used a qualitative approach, data was collected through observation, in-depth interviews, and documentation. Then data reduction is simplified, and data presentation is organized in an organized manner. The validity of the data was checked using a triangulation technique of sources, theories and methods. The results of this study indicate that women's desire to smoke is influenced by different factors, as well as differences in self-control in each individual. The results showed that there were two factors that caused female students to smoke, including the family environment and the friendship environment. The self-control of smoking female students differed from the three informants, namely low self-control (under control), excessive self-control (over control), and appropriate self-control (Appropriate Control).
Abstrak: Banyak ditemukan wanita merokok dengan santai merokok ditempat umum bahkan di kantin kampus. Tulisan ini berusaha mengulas tentang bagaimana kontrol diri wanita terhadap keinginan merokok, khususnya pada mahasiswa jurusan Pendidikan Luar Sekolah di Kota Malang. Penelitian menggunakan pendekatan kualitatif, data dikumpulkan melalui observasi, wawancara mendalam, serta dokumentasi. Kemudian reduksi data dengan disederhanakan, serta penyajian data dengan menyusun secara terorganisir. Keabsahan data diperiksa menggunakan teknik triangulasi sumber, teori dan metode. Hasil penelitian ini menunjukkan bahwa keinginan wanita merokok dipengaruhi oleh faktor yang berbeda, juga dengan adanya perbedaan kontrol diri pada setiap individu. Hasil penelitian menunjukan ada dua faktor penyebab mahasiswi merokok diantaranya faktor lingkungan keluarga dan lingkungan pertemanan. Kontrol diri mahasiswi merokok berbeda dari ketiga informan, yakni kontrol diri yang rendah (under control), kontrol diri yang berlebihan (over control), dan kontrol diri tepat (appropriate control).
Opinion of students on Mobile learning as a tool for classroom teaching and learning
Authors: Navaneetha M , K Mony 
Published: October 2021

Mobile learning, also known as m-Learning, is defined as the need and ability to learn through virtual media, such as personal electronic gadgets, social interactions, and content. A mixed method research was conducted using Concurrent mixed method research design among PG students to know their opinion on m-learning. Google forms were used for collecting data. Themes identified were self learning, convenient/practical, new experience and stress free. The study concludes that m-learning can be used as teaching learning tool and students have positive opinion on its use even though the role of teacher is inevitable.Mobile technology is the future for higher education.
Hodgkin Variant of Richter’s Transformation in Chronic Lymphocytic leukemia (CLL): An Illustrative Case Report and Literature Review
Authors: Gupta Nishit , Mittal Aditi , Duggal Rajan , Dadu Tina , Agarwal Amit , Handoo Anil 
Published: October 2021

Hodgkin lymphoma variant of Richter’s transformation (HL-RT) is a rare event, occurring in < 1% chronic lymphocytic leukemia (CLL) cases, of which, in < 10% cases, HL is the first finding leading to a diagnosis of CLL that co-exists simultaneously. Here we report a 60 years old male patient who presented with an outside diagnosis of lymphocyte-rich classical HL. On evaluation, he had only B-symptoms in the form of low-grade fever and weight loss. Peripheral smear revealed mild leukocytosis with an absolute lymphocytosis and a few smudge cells. Bone marrow (BM) aspirate and biopsy exhibited diffuse infiltration by a small cell, low grade, Non-Hodgkin’s lymphoma with no immunohistochemical evidence of HL. Flow cytometry performed on BM was consistent with classical immunoprofile of CLL. Meanwhile the lymph node received for review revealed diffuse effacement of nodal architecture by small mature lymphocytes with immunoprofile of CLL expressing CD20, CD5, and CD23. Interspersed between these cells, were a few eosinophils along with classical Reed Sternberg cells, expressing CD30, MUM-1, CD15, and dim PAX-5, with a surrounding rosette of T-Cells highlighted by CD3 and PD-1 and negative for CD45, CD20, and EBV immunohistochemistry. Fluorodeoxyglucose positron emission tomography (FDG-PET) scan revealed hepatosplenomegaly with multiple supra/infra diaphragmatic lymph nodes. So, a final diagnosis of HL-RT in CLL was considered. The patient is currently doing well after the first cycle of ABVD chemotherapy.
HL-RT occurring in CLL is a rare event with heterogeneous clinical presentation, morphology, clonal origin, disease course, prognostic features, and survival.
Increasing the efficiency of investments on survey of abundant land for their return to agricultural us
Authors: Stolbovoy V. S. , Petrosyan R. D. , Shilov P. M. , Lukianov S. N. 
Published: October 2021

The "“State program for the effective involvement of abundant agricultural land in the use and the development of the reclamation complex of the Russian Federation” for 2021–2030" assumes the return of 12 million hectares out of 44 million hectares of all abandoned agricultural land (AAL) in the Russian Federation. The costs of 12 million hectares survey can be considered productive, while the costs of surveying the remaining 32 million hectares should be considered unproductive. The application of the new geoinformation database of “Soils of agricultural lands of the Russian Federation” (DB SALRU) developed by the Federal Research Centre “V.V Dokuchaev Soil Sience Institute” allows reduction of unproductive costs. By the example of the Vladimir region, a typical Russian region with AAL, the option of ranking AAL by their quality was demonstrated to determine the order of their return to agricultural use. The soil quality criteria are the bonitet and the normative yield of grain crops, which are part of the DB SALRU. It is proposed to consider the expenditures on the survey of AAL for the soils, which are first to be returned to agricultural use, as productive costs. These soils occupy 25% of the AAL of the region. The best quality soils are characterized by more than 40 points of bonitet and the standard yield of grain crops of more than 20 centners/ha. The cost of surveying the lands of the first order of returning to agricultural use is 10 million 80 thousand rubles. Survey of AAL soils of II–IV orders of involvement in agricultural use, with relatively poor quality compared to the soils of the first order, is proposed to be conducted in the case of expansion of the State program in the future. This would save the unproductive expenses for the survey of AAL for the Vladimir region by 30 million 165.5 thousand rubles. The application of the proposed GIS-approach makes it possible to reduce unproductive expenses for the survey of AAL in the Russian Federation nearly by 5.600 million rubles.
Penguatan pendidikan karakter peserta didik melalui peraturan pondok pesantren di era 4.0
Authors: Kusuma Febra Anjar , Nurhayati  , Susilo  
Published: October 2021

In the current era of the industrial revolution 4.0, strengthening character education is felt to be increasingly necessary, in addition to balancing changes that affect individual behavior, it is also one of the solutions that are considered the most appropriate in addressing moral problems and deviant behavior. This study provides an explanation of how the role of implementing regulations for Islamic boarding schools in shaping and strengthening the character of students/santri in Darul A'mal Islamic boarding schools. The results in this study indicate that the implementation of regulations in the Darul A'mal Islamic boarding school can be a solution to strengthen the character of the students/students in the boarding school. The characters in question are religious, disciplined, independent, polite, and responsible characters.
Abstrak Pada era revolusi industri 4.0 sekarang ini penguatan pendidikan karakter dirasa semakin perlu dilakukan, selain untuk menyeimbangkan perubahan yang mempengaruhi perilaku individu, juga menjadi salah satu solusi yang dianggap paling tepat dalam menyikapi permasalahan moral dan perilaku menyimpang. Penelitian ini memberikan penjelasan mengenai bagaimana peran dari implementasi peraturan pondok pesantren dalam membentuk dan memperkuat karakter peserta didik/santri di pondok pesantren Darul A’mal. Metode yang digunakan dalam penelitian ini yaitu deskriptif kualitatif. Hasil dalam penelitian ini menunjukkan bahwa implementasi peraturan di pondok pesantren Darul A’mal dapat menjadi solusi untuk memperkuat karakter peserta didik/santri yang ada di dalam pondok. Adapun karakter yang dimaksud yakni karakter religius, disiplin, mandiri, dan tanggungjawab
Adaptive Time Stepping, Linearization and a Posteriori Error Control for Multiphase Flow with Wells
Authors: Ahmed E. , Klemetsdal Ø. , Raynaud X. , Møyner O. , Nilsen H. M. 
Published: October 2021

Abstract
We present in this paper a-posteriori error estimators for multiphase flow with singular well sources. The estimators are fully and locally computable, distinguish the various error components, and target the singular effects of wells. On the basis of these estimators we design an adaptive fully-implicit solver that yields optimal nonlinear iterations and efficient time-stepping, while maintaining the accuracy of the solution. A key point is that the singular nature of the solution in the near-well region is explicitly captured and efficiently estimated using the adequate norms. Numerical experiments illustrate the efficiency of our estimates and the performance of the adaptive algorithm.