bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthopaedic Trauma Research Priorities in Latin America
Authors: Roberts Heather J. , MacKechnie Madeline C. , Shearer David W. , Segovia Altieri Julio , de la Huerta Fernando , Rio Marcelo W. , Sánchez Valenciano Carlos , Miclau Theodore ,   the ACTUAR Study Group
Published: September 2021

Background:Despite a substantial burden of musculoskeletal injury, orthopaedic trauma studies in Latin America are lacking. The purpose of the present study was to identify research priorities among orthopaedic trauma surgeons in Latin America.Methods:Research questions were solicited from members of the Asociación de Cirujanos Traumatólogos de las Américas. Participants rated questions by importance from 1 to 9. All questions were redistributed with an aggregate rating, and participants rerated questions with knowledge of group responses.Results:Seventy-eight participants completed the first survey and were included in subsequent surveys. The mean age was 51.8 years, and most participants were male (92%), had completed an orthopaedic trauma fellowship (60.3%), and participated in research (80.8%). Seventeen countries were represented; 5 respondents were from a high-income country, 67 were from an upper middle-income country, and 6 were from a lower middle-income country. Sixty-five questions were identified. Six questions were rated from 1 to 3 (“more important”) by >70% of participants: (1) What is the optimal treatment protocol for elderly patients with hip fracture? (2) What is the most effective initial and definitive management of musculoskeletal injury, including timing and surgical strategy, for the polytraumatized patient? (3) What is the ideal state of open fracture treatment, including timeliness and method of antibiotics, debridement, surgical fixation, and closure or coverage, at each hospital level in the health-care system? (4) What patient and fracture characteristics predict infection after musculoskeletal injury? (5) What is the current state of treatment for fracture-related infection, including timeliness and method of antibiotics and surgical intervention, at each hospital level in the health-care system? (6) What is the optimal protocol for temporary management for the hemodynamically unstable patient with a pelvic or acetabular fracture?Conclusions:This modified Delphi study of orthopaedic trauma surgeons in Latin America identified geriatric hip fractures, polytrauma, open fractures, musculoskeletal infection, and pelvic and acetabular fractures as top research priorities. This information is important for resource allocation and goal setting for orthopaedic trauma in the region.
Meta-analysis of Cryogenian through modern quartz microtextures reveals sediment transport histories
Authors: Reahl Jocelyn N. , Cantine Marjorie D. , Wilcots Julia , Mackey Tyler J. , Bergmann Kristin D. 
Published: September 2021

ABSTRACT
Quantitative analysis of quartz microtextures by means of scanning electron microscopy (SEM) can reveal the transport histories of modern and ancient sediments. However, because workers identify and count microtextures differently, it is difficult to directly compare quantitative microtextural data analyzed by different workers. As a result, the defining microtextures of certain transport modes and their probabilities of occurrence are not well constrained. We used principal-component analysis (PCA) to directly compare modern and ancient aeolian, fluvial, and glacial samples from the literature with nine new samples from active aeolian and glacial environments. Our results demonstrate that PCA can group microtextural samples by transport mode and differentiate between aeolian transport and fluvial and glacial transport across studies. The PCA ordination indicates that aeolian samples are distinct from fluvial and glacial samples, which are in turn difficult to disambiguate from each other. Ancient and modern sediments are also shown to have quantitatively similar microtextural relationships. Therefore, PCA may be a useful tool to constrain the ambiguous transport histories of some ancient sediment grains. As a case study, we analyzed two samples with ambiguous transport histories from the Cryogenian Bråvika Member (Svalbard). Integrating PCA with field observations, we find evidence that the Bråvika Member facies investigated here includes aeolian deposition and may be analogous to syn-glacial Marinoan aeolian units including the Bakoye Formation in Mali and the Whyalla Sandstone in South Australia.
Burden of Communicable and Non-Communicable Diseases Among Elderly in India: A Study Based on LASI Survey
Authors: Chauhan Shekhar , Kumar Shubham , Patel Ratna , Simon David Jean , Singh Aradhana 
Published: September 2021

Abstract
Background: While controlling the outbreak of communicable diseases (CDs) remained a priority, non-communicable diseases (NCDs) are placing an unavoidable burden on the health and social security system. India, a developing nation in South Asia, has seen an unprecedented economic growth in the past few years; however, it struggled to fight the burden of communicable and non-communicable diseases. Therefore, this study aimed at examining the burden of CDs and NCDs among elderly in India.Methods: Data from Longitudinal Ageing Study in India (LASI Wave-I, 2017-18) were drawn to conduct this study. Response variables were the occurrence of CDs and NCDs. The bi-variate and binary logistic regression were used to predict the association between communicable and non-communicable diseases by various socio-demographic and health parameters. Furthermore, to understand the inequalities of communicable and non-communicable diseases in urban and rural areas, the Fairlie decomposition technique was used to predict the contribution toward rural-urban inequalities in CDs and NCDs.Results: Prevalence of communicable diseases was higher among uneducated elderly than those with higher education (31.9% vs. 17.3%); however, the prevalence of non-communicable diseases was higher among those with higher education (67.4% vs. 47.1%) than uneducated elderly. The odds of NCDs were higher among female elderly (OR=1.13; C.I. = 1-1.27) than their male counterparts. Similarly, the odds of CDs were lower among urban elderly (OR=0.70; C.I. = 0.62-0.81) than rural elderly, and odds of NCDs were higher among urban elderly (OR=1.85; C.I. = 1.62-2.10) than their rural counterparts. Results found that education (50%) contributes nearly half of the rural-urban inequality in the prevalence of CDs among the elderly. Education status and current working status were the two significant predictors of widening rural-urban inequality in the prevalence of NCDs among the elderly.Conclusion: The burden of both CD and NCD among the elderly population requires immediate intervention. The needs of men and women and urban and rural elderly must be addressed through appropriate effort. In a developing country like India, preventive measures, rather than curative measures of communicable diseases, will be cost-effective and helpful.
Gene-gene Interaction of AhR with and within the Wnt Cascade Affects Susceptibility to Lung Cancer
Authors: Rosenberger Albert , Muttray Nils , Hung Rayjean J , Christiani David C , Caporaso Neil E , Liu Geoffrey , Bojesen Stig E , Marchand Loic Le , Albanes Demetrios , Aldrich Melinda C , Tardon Adonina , Fernández-Tardón Guillermo , Rennert Gad , Field John K , Davies Michael P.A. , Liloglou Triantafillos , Kiemeney Lambertus A , Lazarus Philip , Wendel Bernadette , Haugen Aage , Zienolddiny Shanbeh , Lam Stephen , Schabath Matthew B , Andrew Angeline S , Duell Eric J , Arnold Susanne M , Goodman Gary E , Chen Chu , Doherty Jennifer A , Taylor Fiona , Cox Angela , Woll Penella J , Risch Angela , Muley Thomas R , Johansson Mikael , Brennan Paul , Landi Maria Teresa , Shete Sanjay S , Amos Christopher I , Bickeböller Heike , consortium INTEGRAL-ILCCO 
Published: September 2021

Abstract
Background

Aberrant Wnt signalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex interaction patterns of genes assigned to AhR/Wnt-signalling were recently associated with lung cancer susceptibility.
Aim

To assess the association and predictive ability of AhR/Wnt-genes with lung cancer in cases and controls of European descent.
Methods

Odds ratios (OR) were estimated for genomic variants assigned to the Wnt agonist and the antagonistic genes DKK2, DKK3, DKK4, FRZB, SFRP4 and Axin2. Logistic regression models with variable selection were trained, validated and tested to predict lung cancer, at which other previously identified SNPs that have been robustly associated with lung cancer risk could also enter the model. Further, decision trees were created to investigate variant x variant interaction. All analyses were performed for overall lung cancer and for subgroups.
Results

No genome-wide significant association of AhR/Wnt-genes with overall lung cancer was observed, but within the subgroups of ever smokers (e.g. maker rs2722278 SFRP4; OR = 1.20; 95%-CI: 1.13–1.27; p = 5.6 10− 10) and never smokers (e.g. maker rs1133683 Axin2; OR = 1.27; 95%-CI: 1.19–1.35; p = 1.0 10− 12). Although predictability is poor, AhR/Wnt-variants are unexpectedly overrepresented in optimized prediction scores for overall lung cancer and for small cell lung cancer. Remarkably, the score for never-smokers contained solely two AhR/Wnt-variants. The optimal decision tree for never smokers consists of 7 AhR/Wnt-variants and only two lung cancer variants
Conclusions

The role of variants belonging to Wnt/AhR-pathways in lung cancer susceptibility may be underrated in main-effects association analysis. Complex interaction patterns in individuals of European descent have moderate predictive capacity for lung cancer or subgroups thereof, especially in never smokers.
Identifying Condom Catheter Component to Optimize Its Function As Intrauterine Balloon Tamponade (Iubt): A Laboratory Test
Authors: Muchlis Mumtihana , Rahman Muhammad Nurhadi , Noor Zannuba Arifah , Chairunnisa Meidini Rahmah , Kurniawati Yustina Tyas 
Published: September 2021

Abstract
Uterine atony is the primary cause of postpartum hemorrhage worldwide. Further management for severe bleeding or limited uterotonic is the insertion of intrauterine balloon tamponade (IUBT), and a modified condom catheter is the most affordable form of IUBT. However, it has some limitations that can emerge from the component of the tools. This study aims to identify the equipment component of the condom catheter and discover potential improvements to optimize its function as IUBT. Preclinical research under laboratory environmental conditions was conducted. Five condom types, six catheter sizes, and a type of macro drip IV tubing were included in the study. The specifications of all condoms were almost similar and did not significantly differ in capacity, shape, and leakage. The condom shapes were more rounded and had a high possibility of filling the uterine space entirely if tied in the middle instead of close to the tip based on the standard. There was no significant time difference (p = 0.111; CI95% 3.31–3.52) in draining the fluid when using large catheters (nos 18F, 20F, 22F, and 24F) and removing the catheter. However, not using a catheter should consider the device's required length and mother's comfort in early mobilization. Also, further clinical studies are highly recommended.
New challenges towards ecological management of Paliastomi Lake will significantly improve local environment with far-going global consequences
Authors: Abramia Grigol , Gverdtsiteli Leil , Eristavi Dimitri , Kalandadze Besik , Girgvliani Akaki , Weber Gero , Honecker Ulrich , Kubiniok Jochen , Golijashvili Alexander , Japarashvili Nana 
Published: September 2021

Abstract
The publication is addressing the problems of pollution from agricultural sources; municipal wastewater and industry in line with the bacterial pollution caused by migratory waterfowl of Paliastomi Lake that is an internationally recognized habitat, wintery and transit area of the birds and an important tourism site. It reviews: the current state of the environment of Paliastomi Lake at the moment of the chemical and microbiological research and mathematical simulation modeling of possible dissemination of polluting chemicals and bacterial pathogens; pollution by nutrient-rich water causing large blooms of algae and aquatic plants that in its turn leaves little oxygen for fish and other aquatic animals, resulting in the eutrophication followed by suffocation of aquatic life.
Pattern of Prescription Practices in Acute Respiratory Infection and Diarrhoea Cases in Out Patient Department of Tertiary Care Hospitals in West Bengal, India; A Cross Sectional Analysis through Rational Use of Medicine Consensus Approach
Authors: Chakraborty Debjit , Debnath Falguni , Kanungo Suman , Chakraborty Nabanita , Basu Rivu , Das Palash , Datta Kalpana , Ganguly Suman , Banerjee Prithwijit , Dutta Shanta 
Published: September 2021

Abstract
Background: Evaluation of prescription patterns would determine the drug utilization with main emphasis on rational use of medicine. The problem of irrational use of drugs is rampant particularly in developing nations. The present study was undertaken for evaluating the prevailed prescription patterns in tertiary hospitals with diarrhoea and/or Acute Respiratory Infection (ARI) to address specific areas of deficiencies and deviation from the available guidelines. Method: We conducted this observational cross-sectional study from August 2019 to December 2020 in Medicine & Paediatrics outpatient departments and Urban Health Training Centre in two Government teaching hospitals in West Bengal, India. We included 630 prescriptions (511 – ARI, 119- diarrhoea) and evaluated in terms of disease and medicine prescribed including antibiotic related indicators. We compared prescription patterns across different age groups, different strata of prescribers and compared against WHO standards. A Rational Use of Medicine Consensus (RUMC) committee was formed and the prescriptions were assessed for appropriateness independently by a pharmacologist and clinician. Deviations, if any, were ascertained from the available guidelines and the acceptability of the deviations were determined by consensusResult: Age and sex were mentioned in all prescriptions however signs & symptoms, provisional diagnosis and follow up visit were mentioned in 90.3%, 4.9% and 67.9% prescriptions respectively. Body weight was mentioned in 88.5% of prescription of children (< 18 years). Higher rates of Fixed Dose Combination (51%), lower proportion of generic drug (23.3%) and adherence to hospital formulatory (36.5%) were some the major concerns identified. Antibiotics prescription rate (APR) and multiple antibiotic prescription rate (MPR) were respectively 57% and 10%; both found significantly higher for diarrhoea than ARI. Deviations from Standard Treatment Guidelines were found in 98.9% prescriptions and 90.4% of which were unacceptable. Agreement between clinician and pharmacologist was observed in 90% prescriptions (Kappa -0.114). Deviations were most commonly observed with prescriptions by interns and house-staff (99.6%), whereas acceptable deviations were more frequent among the residents (15%).Conclusion: We conclude that in light of identified irrational prescription patterns, development of level specific treatment protocol coupled with periodic training of physician including junior doctors is required to ensure rational medicine practice.
Anxiety and Depression Among Adult Tobacco Users During the COVID-19 Restrictions in India.
Authors: Bassi Shalini , Nazar Gaurang P. , Joshi Nishigandha , Sharma Nitika , Pandian Aishwarya , Mohan Deepa , Mohan Sailesh , Patel Shivani , Ali MK , McNeill Ann , Tandon Nikhil , Mohan V , Prabhakaran Dorairaj , Arora Monika 
Published: September 2021

Abstract
Background
The world witnessed a highly contagious and deadly disease, COVID-19, towards the end of 2019. India is one of the worst affected countries. We aimed to assess anxiety and depression levels among adult tobacco users and people who recently quit tobacco during COVID − 19 lockdown in India.
Methods
The study was conducted across two Indian cities, Delhi and Chennai (July-August, 2020) among adult tobacco users (n = 801). Telephonic interviews were conducted using validated mental health tools (Patient Health Questionnaire-PHQ-9 and Generalized Anxiety Disorder-GAD-7) to assess the anxiety and depression levels of the participants. Descriptive analysis and multiple logistic regression were used to study the prevalence and correlates of depression and anxiety.
Results
We found that 20.6% of tobacco users had depression symptoms (3.9% moderate to severe); 20.7% had anxiety symptoms (3.8% moderate to severe). Risk factors associated with depression and anxiety included food, housing, and financial insecurity.
Conclusion
During COVID-19 lockdown, mental health of tobacco users (primarily women) was associated with food, housing and financial insecurity. The Indian Government rightly initiated several health, social and economic measures to shield the most vulnerable from COVID-19, including a ban on the sale of tobacco products. It is also necessary to prioritize easy access to tobacco cessation and mental health services to such vulnerable populations during pandemic situations.
Post-Acute Care Service use in Lung Cancer Patients
Authors: McLarney Mitra , Shofer Frances S. , Zheng Jasmine 
Published: September 2021

Abstract
Purpose: Lung cancer patients experience functional deconditioning secondary to their underlying cancer and treatment yet rehabilitation service use remains low. The goal of this study is to compare post-acute care service use in lung cancer patients admitted to a metropolitan academic medical center. Methods: Adult lung cancer patients admitted from January 1, 2017 to August 31, 2018 with a diagnosis of lung cancer based on International Classification of Diseases 10, C34.0-C34.9, were included in this study. Patient characteristics including age, gender, race, marital status, functional status on admission, length of stay, and number of comorbidities were compared based on discharge setting. Results: 1,139 lung cancer patients were included in our study. The majority of patients discharged home with home care (51%) followed by home without services (35%), skilled nursing facilities (SNF) (10%) and acute inpatient rehabilitation facilities (IRF) (4%). 44% (498) of patients were primarily admitted for their lung cancer diagnosis. In unadjusted analyses, patients who discharged to SNF compared to home were more likely to be older, black, unmarried, live alone and have died during the study period. Patients who discharged to IRF had longer acute care hospitalization length of stays. In adjusted analyses, age, number of concurrent comorbidities and length of stay significantly correlated with discharge location. Conclusion: Lung cancer patients are unlikely to be discharged to a post-acute care facility after an acute hospitalization. Rehabilitation service use differs by sociodemographic factors, concurrent medical history and functional status. Future study is needed to better understand why these differences in discharge setting persists.
Ononin Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting ER Stress Through Activation of SIRT3
Authors: Sun Shimin , Weng Jingfan , Yang Qi , Huang Xingxiao , Zhang Hanlin , Sun Jing , Lu Wenqiang , Chi Jufang , Guo Hangyuan 
Published: September 2021

Abstract
Introduction

Doxorubicin (DOX) is a powerful anthracycline antineoplastic drug, but the clinical application of DOX is seriously limited by its dose-dependent cardiotoxicity. Ononin is a natural isoflavone glycoside and plays a key role in modulating apoptosis related signaling pathways. The aim of this study was to assess the possible cardioprotective effects of Ononin in DOX-induced cardiotoxicity and the underlying molecular mechanisms.
Materials and methods

Wistar rats were treated with normal saline, DOX with or without Ononin. After the last administration, cardiac function was evaluated by echocardiography. Rats were then sacrificed for histological and TUNEL analyses, with immunological detection for β-actinin, Bax, Bcl-2, GRP78, CHOP and SIRT3. An enzyme-linked immunosorbent assay was performed to assess the myocardial injury markers. H9C2 cells were treated with vehicle, DOX with or without Ononin. Then, 3-TYP was used to find out the relationship between ER stress and SIRT3.
Results

Ononin treatment ameliorated DOX-induced myocardial injury as demonstrated by echocardiography. Ononin partially restored DOX-induced cardiac dysfunction, both LVEF and LVFS were increased under the cotreatment of Ononin. Ononin also inhibited DOX-induced ER stress and apoptosis in rat cardiomyocytes and H9C2 cells. DOX group had a higher Bax/Bcl-2 ratio, GRP78 and CHOP expression then control group, but Ononin treatment improved these results. This effect was associated with SIRT3 activity, moreover, selective inhibition of SIRT3 blocked the protective effects of Ononin.
Conclusion

In the present study, we tested the hypothesis that Ononin may protect against DOX-induced cardiomyopathy through ER stress both in vitro and in vivo. Ononin is able to protect against DOX-induced cardiotoxicity by inhibiting ER stress and apoptosis, this effect may via stimulation of the SIRT3 pathway.
Evaluation of Collapse Sensitivity of Loess Soils and Its Effect on the Distribution Pattern of Pseudokarst Sinkholes at the Regional Scale (Case Study: Golestan Province, Northeastern Iran)
Authors: Zalaghaie Seddighe , Heidari Mojtaba , Nikudel Mohammad Reza 
Published: September 2021

Abstract
The spread of loess soils in Golestan Province in northeastern Iran has caused considerable environmental issues. To evaluate the effect of loess collapse on the spatial distribution of pseudokarst sinkholes in this province, we have prepared undisturbed samples from 31 locations and characterized their physical and mechanical properties. Moreover, the collapse sensitivity in different parts of the study area has been determined by odometer tests under different pressures and calculation of three parameters, namely, the collapse coefficient (Ic), the time required for 90% settlement due to soil collapse (T90%), and initial collapse stress. Additionally, by conducting field surveying, using aerial photographs, satellite images, and drone flight, the coordinates of sinkholes were identified, and a map of their geographical distribution was prepared. The overlap of the sinkholes distribution map and the coefficient of collapse changes map showed that although the amount of Ic of sandy loess soils (Zone III) is higher than that of silty loess soils (Zone II), the extent of destructive phenomena such as sinkholes is much greater in Zone II than in Zone III. The overlap of the map of sinkholes distribution with the map of changes in collapse sensitivity (Is) of loess soils showed that the density of sinkholes in Zone II (which has higher collapse sensitivity) is higher than Zone III. In Zone II, due to severe collapse sensitivity, the highest concentration of sinkholes is observed in a unit area, more than 0.18 per square kilometer. With a relatively severe to severe collapse sensitivity in Zone III, this concentration is 0.021 per square kilometer. In Zone I (clayey loess), with slight-moderate collapse sensitivity, this destructive phenomenon is observed in the form of side instability since the study area is located in highlands. Furthermore, in this area, the sinkholes (0.004 per square kilometer) have the least concentration.