bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transforming Growth Factor-β3/Recombinant Human-like Collagen/Chitosan Freeze-Dried Sponge Primed With Human Periodontal Ligament Stem Cells Promotes Bone Regeneration in Calvarial Defect Rats
Authors: Huang Shiyi , Yu Fenglin , Cheng Yating , Li Yangfan , Chen Yini , Tang Jianzhong , Bei Yu , Tang Qingxia , Zhao Yueping , Huang Yadong , Xiang Qi 
Published: April 2021

Patients with a skull defect are at risk of developing cerebrospinal fluid leakage and ascending bacterial meningitis at &gt;10% per year. However, treatment with stem cells has brought great hope to large-area cranial defects. Having found that transforming growth factor (TGF)-β3 can promote the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs), we designed a hybrid TGF-β3/recombinant human-like collagen recombinant human collagen/chitosan (CS) freeze-dried sponge (TRFS) loading hPDLSCs (TRFS-h) to repair skull defects in rats. CFS with 2% CS was selected based on the swelling degree, water absorption, and moisture retention. The CS freeze-dried sponge (CFS) formed a porous three-dimensional structure, as observed by scanning electron microscopy. In addition, cytotoxicity experiments and calcein-AM/PI staining showed that TRFS had a good cellular compatibility and could be degraded completely at 90 days in the implantation site. Furthermore, bone healing was evaluated using micro-computed tomography in rat skull defect models. The bone volume and bone volume fraction were higher in TRFS loaded with hPDLSCs (TRFS-h) group than in the controls (p &lt; 0.01, vs. CFS or TRFS alone). The immunohistochemical results indicated that the expression of Runx2, BMP-2, and collagen-1 (COL Ⅰ) in cells surrounding bone defects in the experimental group was higher than those in the other groups (p &lt; 0.01, vs. CFS or TRFS alone). Taken together, hPDLSCs could proliferate and undergo osteogenic differentiation in TRFS (p &lt; 0.05), and TRFS-h accelerated bone repair in calvarial defect rats. Our research revealed that hPDLSCs could function as seeded cells for skull injury, and their osteogenic differentiation could be accelerated by TGF-β3. This represents an effective therapeutic strategy for restoring traumatic defects of the skull.
A Qualitative Exploration of Sport and Social Pressures on Elite Athletes in Relation to Disordered Eating
Authors: Stoyel Hannah , Delderfield Russell , Shanmuganathan-Felton Vaithehy , Stoyel Alex , Serpell Lucy 
Published: April 2021

Introduction:Athletes are at increased risk of disordered eating compared to non-athletes. Inspired by previous investigation into quantitative work on an etiological model of disordered eating in athletes, the current study aimed to explore a problematic aspect of the model: athletes' lived experiences of social and sport pressures in relation to the onset of disordered eating and differing eating behaviors.Methods:Nine (N= 9) male and female athletes representing a range of endurance sports took part in semi-structured interviews. Thematic analysis was utilized.Analysis:Analysis revealed two main themes each with two corresponding subthemes (1) Conflating physical appearance and sporting ability with the subthemes of (1a) social comparison in a sporting world and (1b) societal notions of “the athlete body” and (2) Living as an athlete with the corresponding subthemes of (2a) discipline and sacrifice and (2b) the balancing act.Discussion:It is the complex interaction between societal expectations as lived out in social messages and comparisons, and sport pressures that contributes to the development of disordered eating behaviors. These findings suggest that prevention and treatment of disordered eating in athletes can be applied from those already established in non-sporting realm.
Mental Burden of Hospital Workers During the COVID-19 Crisis: A Quanti-Qualitative Analysis
Authors: Luquiens Amandine , Morales Jennifer , Bonneville Marion , Potier Hugo , Perney Pascal , Faure Gilles , Canaguier Astrid 
Published: April 2021

Context: This study is a quanti-qualitative analysis of all contacts to a helpline service for hospital workers during the COVID-19 crisis. Our aim was to describe the nature of mental burden in hospital workers and factors subjectively associated to this burden from the workers' perspective.Methods: We included all 50 contacts from 25 different workers and 10 different professions over the course of 1 month. We described the corpus and reported the computerized qualitative analysis of summary of contacts. We performed a descendant hierarchical analysis and analyzed specificities of classes of age with a correspondence factor analysis.Results: The corpus was composed of three classes: (1) distress specific to the COVID-19 situation, (2) help provided, and (3) pre-existing psychological vulnerability. Factors subjectively responsible for mental distress were: (a) the contamination risk, (b) confinement, and (c) the rapidly evolving situation and changing instructions. Lack of “COVID-free time” seemed to increase negative emotions. Reassignment to a high viral density unit was a stressor, especially in older workers. Young workers mentioned pre-existing vulnerability more than others. Fear of death was shared by all classes of age, regardless of the objective risk of contamination.Discussion: Hospital workers experience mental distress factors both in common with the general population and specific to the hospital environment. Preserving and organizing support for the mental health of all hospital workers is a critical challenge, including those with poorly recognized professions. Leads for institutions to avoid additional stressors for hospital workers are presented. Young workers with pre-existing vulnerability seem particularly impacted.
Supported Employment, Participation at Work, and Peer Support: A Qualitative, Participatory Case Study Report of the Geesthacht Model
Authors: von Peter Sebastian , Göppert Lena , Ziegenhagen Jenny , Beeker Timo , Glück Rosa , Groth Birte , Groß Uwe , Reinholdt Arne , Boerma Robin , Heißler Matthias , Habicht Juri , Schwarz Julian 
Published: April 2021

Background:For people who have experienced mental health crises or psychosocial disabilities, it is considerably more difficult to receive support to participate in work on an equal basis with others. In the town of Geesthacht, in Northern Germany, an integrative care network was implemented that allows for acute psychiatric treatment as well as participation in work and activities. This paper aims to explore the principles, advantages, and challenges of this innovative project.Methodology:Within the context of a participatory and collaborative process evaluation of a prospective controlled cohort study (PsychCare), researchers with and without experiential expertise conducted expert interviews and focus groups to evaluate the experiences of 37 employees, with and without lived experience, from various institutions associated with this care network. The data was analyzed using qualitative content analysis.Results:It was the change from financial compensation paid on a daily basis to a global treatment budget that allowed for a significant reduction of hospital beds in Geesthacht and freed up resources to implement a complex care network. Since then, various possibilities for participation, work, and activities for former service users, some of which are compensated financially, have been made available. These developments now allow for a less bureaucratic and often smooth transition from being a service user to involvement in participatory activities in the role of a peer, which is frequently perceived to be empowering and beneficial by participants with lived experience. At the same time, this care model has led to multiple role conflicts and different challenges for all parties involved.Conclusion:This innovative project in Geesthacht demonstrates the multifaceted potential of a global treatment budget system in the field of mental health care. To address certain downsides of the Geesthacht model, further development is necessary.
RETRACTED: Tumor Microenvironment in Oral Cancer Following Neoadjuvant Pembrolizumab: Preliminary Analysis of the Histopathologic Findings
Authors: Dobriyan Alex , Gluck Iris , Alon Eran , Barshack Iris , Yahalom Ran , Vered Marilena 
Published: April 2021

Background: The tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC) is associated with immune suppression, one of the pathways being the programmed death receptor 1 (PD-1) and its ligands (PD-L1/PD-L2). Checkpoint inhibitors of PD-1/PD-L1, like pembrolizumab, have been recently approved for treatment of OSCC. We described the histologic findings in OSCC following neoadjuvant pembrolizumab, including identification of immune-related cell populations and cancer-associated fibroblasts (CAFs).Materials and Methods: Patients with OSCC clinical stages 3 and 4 and a combined PD-L1 score &gt;1 were randomized either to the standard oncologic protocol or to the pembrolizumab arm of MK-3475-689 study for Head and Neck, Lip, and Oral Cavity. The latter were given two standard doses of 200 mg of pembrolizumab, 3 weeks apart, and then underwent surgical oncologic procedure according to the initial stage. Sections from the resection specimens were analyzed for pathological response to pembrolizumab. Various populations of immune-related cells within the tumor microenvironment were characterized by immunohistochemistry, as were the CAFs.Results: Three patients who were randomized to the pembrolizumab study were described. One patient presented with a tongue SCC, the other two had SCC of the mandibular ridge with bony involvement. Only the patient with tongue SCC showed clinical complete response. Microscopically, the tumor was replaced by a granulomatous type of inflammation. Immunohistochemical stains revealed massive T cell rich (CD3+) infiltrate, with approximately equal amounts of CD4+ and CD8+ cells, numerous macrophages of CD68+ and CD163+ phenotypes; no CAFs were identified. The other two patients were regarded as non-responders as at least 50% of the tumor was viable. The tumor microenvironment of these tumors was generally associated with a lesser extent of inflammatory response compared to the tongue tumor, a variable CD4+/CD8+ ratio and presence of CAFs. Neither T regulatory cells (FOXP3+) nor natural killer cells (CD56+, CD57+) were identified in any of the cases.Conclusion: We showed that characterizing the specific populations of immune-related cells and CAFs after treatment with pembrolizumab, may add to our understanding of the tumor-TME interactions in this setting. These findings should be investigated in future studies on a larger number of patients.
Wick technique in subscleral and subconjunctival Ologen™ implantation with trabeculectomy in patients with high risk of failure
Authors: Rajamani Muralidhar , Ramamurthy Chitra 
Published: April 2021

Introduction: Ologen™ is traditionally placed subconjunctivally during trabeculectomy, which limits its area of action. Subscleral implantation of Ologen has been described involving fashioning a gutter beneath the scleral flap. This, however, would not prevent fibrosis at the margins of the scleral flap. We describe a modified technique of Ologen® placement that has the potential to prevent scarring at the margins of the flap withoutthe need to fashion a gutter.
Materials and methods: The study involved a retrospective review of patients who had undergone trabeculectomy with Ologen implantation by the wick technique between January 2015 and August 2016. Patients judged to be at high risk of trabeculectomy failure were operated with this technique.
Results: A total of six patients with median age of 38.5 years were included in the study. The mean preoperative intraocular pressure (IOP) was 30.8 ± 7.3 mmHg, which reduced to 10.6 ± 2.2 mmHg 18 months after surgery. By 18 months postoperative, all patients had IOP in the low teens (two patients required additional topical medication). One patient had two episodes of hypotony that responded to steroids and cycloplegics. Another patient required two needlings to bring IOP under control. No other complications were noted. Ultrasound biomicroscopy done 3 months after surgery showed two pieces of Ologen in one patient.
Conclusions: The results of our study show that this technique may be used effectively in patients at high risk of trabeculectomy failure. Further studies in a larger number of patients with diverse high-risk conditions are required before this technique is recommended for general use.
Exploration of the Origin of Galactic and Extragalactic Star Clusters through Simulated H-R Diagrams
Authors: Chattopadhyay Tanuka , Mondal Sreerup , Paul Suman , Maji Subhadip , Kumar Chattopadhyay Asis 
Published: April 2021

Abstract
The present work explores the origin of the formation of star clusters in our Galaxy and in the Small Magellanic Cloud (SMC) through simulated H-R diagrams and compare those with observed star clusters. The simulation study produces synthetic H-R diagrams through the Markov Chain Monte Carlo (MCMC) technique using the star formation history (SFH), luminosity function (LF), abundance of heavy metal (Z), and a big library of isochrones as basic inputs and compares them with observed H-R diagrams of various star clusters. The distance-based comparison between those two diagrams is carried out through two-dimensional matching of points in the color−magnitude diagram (CMD) after the optimal choice of bin size and appropriate distance function. It is found that in a poor medium of heavy elements (Z = 0.0004), the Gaia LF along with a mixture of multiple Gaussian distributions of the SFH may be the origin of formation of globular clusters (GCs). On the contrary, an enriched medium (Z = 0.019) is generally favored with the Gaia LF along with a double power law or Beta-type (i.e., unimodal) SFH, for the formation of globular clusters. For SMC clusters, the choice of an exponential LF and exponential SFH is the proper combination for a poor medium, whereas the Gaia LF with a Beta-type SFH is preferred for the formation of star clusters in an enriched medium.
The Colors of Bulges and Disks in the Core and Outskirts of Galaxy Clusters
Authors: Barsanti S. , Owers M. S. , McDermid R. M. , Bekki K. , Bryant J. J. , Croom S. M. , Oh S. , Robotham A. S. G. , Scott N. , van de Sande J. 
Published: April 2021

Abstract
The role of the environment on the formation of S0 galaxies is still not well understood, specifically in the outskirts of galaxy clusters. We study eight low-redshift clusters, analyzing galaxy members up to cluster-centric distances of ∼2.5 R
200. We perform 2D photometric bulge–disk decomposition in the g, r, and i bands from which we identify 469 double-component galaxies. We separately analyze the colors of the bulges and disks and their dependence on the projected cluster-centric distance and local galaxy density. For our sample of cluster S0 galaxies, we find that bulges are redder than their surrounding disks, show a significant color–magnitude trend, and have colors that do not correlate with environment metrics. On the other hand, the disks associated with our cluster S0s become significantly bluer with increasing cluster-centric radius but show no evidence for a color–magnitude relation. The disk color–radius relation is mainly driven by galaxies in the cluster core at 0 ≤ R/R
200 < 0.5. No significant difference is found for the disk colors of backsplash and infalling galaxies in the projected phase space (PPS). Beyond R
200, the disk colors do not change with the local galaxy density, indicating that the colors of double-component galaxies are not affected by preprocessing. A significant color–density relation is observed for single-component disk-dominated galaxies beyond R
200. We conclude that the formation of cluster S0 galaxies is primarily driven by cluster core processes acting on the disks, while evidence of preprocessing is found for single-component disk-dominated galaxies. We publicly release the data from the bulge–disk decomposition.
Observing the Time Evolution of the Multicomponent Nucleus of 3C 84
Authors: Punsly Brian , Nagai Hiroshi , Savolainen Tuomas , Orienti Monica 
Published: April 2021

Abstract
The advent of global millimeter-band very long baseline interferometry (VLBI) in recent years has finally revealed the morphology of the base of the two most prominent nearby, bright, extragalactic radio jets in M87 and 3C 84. The images are quite surprising considering the predictions of jet theory and current numerical modeling. The jet bases are extremely wide compared to expectations, and the nucleus of 3C 84 is very complicated. It appears as a double nucleus in 86 GHz observations with 50 μas resolution and a triple nucleus with 30 μas resolution with space-based VLBI by RadioAstron at 22 GHz. What is even odder is that the double and triple nuclei are arranged along an east–west line that is approximately orthogonal to the north–south large-scale jet on 150 μas−4 mas scales. We explore the emergence of an (east–west) double nucleus in the lower-resolution 43 GHz Very Long Baseline Array (VLBA) imaging from 2018 August to 2020 April. The double nucleus is marginally resolved. We exploit the east–west resolution associated with the longest baselines, ∼0.08 mas, to track a predominantly east–west separation speed of ≈0.086 ± 0.008c. We estimate that the observed mildly relativistic speed persists over a deprojected distance of ∼1900–9800 times the central, supermassive black hole gravitational radius (∼0.3–1.5 lt-yr) from the point of origin.
Jet–Accretion System in the Nearby mJy Radio Galaxies
Authors: Grandi Paola , Torresi Eleonora , Macconi Duccio , Boccardi Bia , Capetti Alessandro 
Published: April 2021

Abstract
It is generally thought that FRII radio galaxies host thin optically thick disks, while FRIs are powered by advection-dominated accretion flows. Sources with an efficient engine are optically classified as high-excitation radio galaxies (HERGs) and those with an inefficient motor as low-excitation radio galaxies (LERGs). Recently, the study of radio galaxies down to mJy fluxes has cast serious doubts on the LERG-FRI and HERG-FRII correspondence, revealing that many LERGs show FRII radio morphologies. The FR catalogs recently compiled by Capetti et al. and Baldi et al. have allowed us to explore this issue in the local (z ≤ 0.15) mJy universe. Our statistical study shows that the majority of nearby mJy objects are in a late stage of their life. FRII-LERGs appear more similar to the old FRI-LERGs than to the young FRII-HERGs. FRII-LERGs may be aged HERGs that, having exhausted their cold fuel, have changed their accretion regime or are a separate LERG class particularly efficient in launching jets. Exploiting the empirical relations that convert L
[O III] and L
1.4 GHz into accretion power and jet kinetic power, respectively, we observed that LERGs with similar masses and accretion rates seem to expel jets of different powers. We speculate that intrinsic differences related to the black hole properties (spin and magnetic field at its horizon) can determine the observed spread in jet luminosity. In this view, FRII-LERGs should have the fastest spinning black holes and/or the most intense magnetic fluxes. On the contrary, compact LERGs (i.e., FR0s) should host extremely slow black holes and/or weak magnetic fields.
101 Trojans: A Tale of Period Bimodality, Binaries, and Extremely Slow Rotators from K2 Photometry
Authors: Kalup Csilla E. , Molnár László , Kiss Csaba , Szabó Gyula M. , Pál András , Szakáts Róbert , Sárneczky Krisztián , Vinkó József , Szabó Róbert , Kecskeméthy Viktória , Kiss László L. 
Published: April 2021

Abstract
Various properties of Jovian Trojan asteroids such as composition, rotation periods, and photometric amplitudes, or the rate of binarity in the population, can provide information and constraints on the evolution of the group and of the solar system itself. Here we present new photometric properties of 45 Jovian Trojans from the K2 mission of the Kepler space telescope, and present phase-folded light curves for 44 targets, including (11351) Leucus, one of the targets of the Lucy mission. We extend our sample to 101 asteroids with previous K2 Trojan measurements, then compare their combined amplitude and frequency distributions to other ground-based and space data. We show that there is a dichotomy in the periods of Trojans with a separation at ∼100 hr. We find that 25% of the sample are slow rotators (P ≥ 30 hr), an excess that can be attributed to binary objects. We also show that 32 systems can be classified as potential detached binary systems. Finally, we calculate density and rotation constraints for the asteroids. Both the spin barrier and fits to strengthless ellipsoid models indicate low densities and thus compositions similar to populations of comets and trans-Neptunian objects throughout the sample. This supports the scenario of outer solar system origin for Jovian Trojans.
Identifications
Authors: Gorog Jean-Jacques 
Published: April 2021

La question de l’identification suit chez Lacan une voie étroite qui suppose à chaque pas un franchissement et par conséquent une identification nouvelle. Chacun des complexes familiaux en fournit une modalité. La voie royale est l’identification au signifiant, mais pour que le franchissement qu’elle implique se produise, l’inscription dans le corps exige d’une part, une incorporation du signifiant et d’autre part, que celui-ci acquière quelque consistance, une image, bref une identité, où l’on reconnaisse le symbolique du trait, le réel de l’incorporation et l’imaginaire du corps dans le miroir. Le texte se limite pour l’essentiel à la période qui précède le séminaire de Lacan « L’Identification » et montre comment le résultat exige une conception de l’identification où le rêve d’une unité échappe nécessairement. Chaque fois que l’unité, l’ être comme , apparaît, elle est, dans la clinique, mauvais signe, signe qu’on a quitté le domaine de l’identification freudienne.
Identifications primordiales et identité
Authors: Montel Jean-Paul 
Published: April 2021

Lacan va dégager le paradigme du trait unaire des trois identifications composites de Freud. Il leur donne ainsi leur ossature. Il va d’ailleurs les décliner tour à tour dans leur articulation à l’Imaginaire, au Symbolique et au Réel. Dans sa référence à l’analyse, la chute des identifications se dénoue dans l’identification au symptôme de fin de cure qui est aussi identité de séparation. Nous quittons ainsi le pluriel pour entrer dans le singulier. Dans son séminaire « L’Identification » des années 1961-1962, il réoriente la question de l’identité à partir du Un. L’effort de logification l’amènera à prendre appui sur les travaux de Frege pour lui donner sa consistance. Partant du Un, il va ainsi en dégager la dichotomie : à la fois index de l’unité, mais aussi opérateur de la pure différence qui produit le non-identique à lui-même et donc le multiple. Par là même se trouve remise en question la logique aristotélicienne classique.
L’identification, impossible ?
Authors: Pellion Frédéric 
Published: April 2021

L’identification n’est pas retenue par Lacan parmi les quatre concepts fondamentaux de la psychanalyse. Cela surprend quand on sait la place du phénomène dans la clinique quotidienne, dans l’œuvre théorique de Freud, et pour Lacan lui-même, qui écrivait en 1950 : « L’identification, c’est la causalité psychique même 2 . » C’est que l’identification, pour fondamentale qu’elle soit, échoue à être un concept. Et de fait, à relire attentivement le séminaire éponyme, on pourra mettre en série quelques arguments en faveur de cette hypothèse ; et, de l’aveu ultérieur de Lacan lui-même, c’est peut-être bien son objet a qui vient à la place du concept de l’identification qu’il n’y a pas.