bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological and Biochemical Effects of an Aqueous Extract of Lemna minor L. as a Potential Biostimulant for Maize
Authors: Del Buono Daniele , Bartucca Maria Luce , Ballerini Eleonora , Senizza Biancamaria , Lucini Luigi , Trevisan Marco 
Published: September 2021

AbstractBiostimulants are receiving increasing attention for their beneficial effects on crops, driving interest in identifying new plant extracts that could exert such stimulatory effects. This work aimed to evaluate the potential of an aqueous extract obtained from duckweed (Lemna minor L.), a freshwater species, to act as a biostimulant in maize. For this purpose, duckweed plants were collected from a natural basin and then transferred, stabilized, and grown under controlled conditions. The duckweed extract was first characterized through untargeted profiling, which revealed an abundance of bioactive phytochemicals. A relatively high amount of low-molecular-weight secondary metabolites such as phenolics (6714.99 mg kg−1) and glucosinolates (4563.74 mg kg−1) were present in the plant extract. Maize seeds were primed with different concentrations of this extract (0.01%, 0.05%, 0.50%, and 1.00%, dry weight/water volume), and some physiological and biochemical traits of the crop were recorded. The duckweed extract improved maize germination, biomass, leaf area, pigment content, and vigor index. The most effective treatment was the 0.50% concentration, which improved the majority of the measured growth traits. The extract at concentrations of 0.05%, 0.50%, and 1.00% stimulated the assimilation of nitrogen (N), phosphorous (P), potassium (K), calcium (Ca), magnesium (Mg), sodium (Na), iron (Fe), and copper (Cu). In summary, this study revealed that duckweed is a promising species that can be cultured and grown under controlled conditions for obtaining extracts with biostimulant properties.
Vascular surgery in liver resection
Authors: Radulova-Mauersberger Olga , Weitz Jürgen , Riediger Carina 
Published: September 2021

AbstractVascular surgery in liver resection is a standard part of liver transplantation, but is also used in oncological liver surgery. Malignant liver tumors with vascular involvement have a poor prognosis without resection. Surgery is currently the only treatment to provide long-term survival in advanced hepatic malignancy. Even though extended liver resections are increasingly performed, vascular involvement with need of vascular reconstruction is still considered a contraindication for surgery in many institutions. However, vascular resection and reconstruction in liver surgery—despite being complex procedures—are safely performed in specialized centers. The improvements of the postoperative results with reduced postoperative morbidity and mortality are a result of rising surgical and anesthesiological experience and advancements in multimodal treatment concepts with preconditioning measures regarding liver function and systemic treatment options. This review focuses on vascular surgery in oncological liver resections. Even though many surgical techniques were developed and are also used during liver transplantation, this special procedure is not particularly covered within this review article. We provide a summary of vascular reconstruction techniques in oncological liver surgery according to the literature and present also our own experience. We aim to outline the current advances and standards in extended surgical procedures for liver tumors with vascular involvement established in specialized centers, since curative resection improves long-term survival and shifts palliative concepts to curative therapy.
Current practice of stress ulcer prophylaxis in a surgical patient cohort in a German university hospital
Authors: Rauch Julia , Patrzyk Maciej , Heidecke Claus-Dieter , Schulze Tobias 
Published: September 2021

Abstract
Introduction
Stress ulcer prophylaxis (SUP) has been a widespread practice both in intensive care units (ICU) and internal wards at the beginning of the twenty-first century. Clinical data suggests an important overuse of acid suppressive therapy (AST) for this indication. Data on current clinical practice of SUP in surgical patients in a non-ICU setting are spares. In the light of a growing number of reports on serious side effects of AST, this study evaluates the use of AST for SUP in a normal surgical ward in a German university hospital.

Methods
Between January 2016 and June 2016, SUP was analysed retrospectively in 1132 consecutive patients of the Department of Surgery of the Universitätsmedizin Greifswald.

Results
The patients managed with and without SUP were similar with respect to demographic data and treatment with anticoagulants, SSRI and glucocorticoids. Patients with SUP were treated more frequently by cyclooxygenase inhibiting drugs (NSAID, COX2-inhibitors), were more frequently treated in the intermediated care unit and had a longer hospital stay. Risk factors for the development of stress ulcers were similarly present in patient groups managed with and without SUP. About 85.7–99.6% of patients were given SUP without an adequate risk for stress ulcer development, depending on the method used for risk assessment.

Discussion
Still today, SUP is widely overused in non-ICU surgical patients. Information campaigns on risk factors for stress ulcer development and standard operating procedures for SUP are required to limit potential side effects and increased treatment costs.
The relation between sleep quality, sleep quantity, and gastrointestinal problems among colorectal cancer survivors: result from the PROFILES registry
Authors: Schoormans Dounya , van Es Bonita , Mols Floortje , Wasowicz Dareczka , Beijer Sandra , Ezendam Nicole P. M. 
Published: September 2021

Abstract

Purpose
Common residual symptoms among survivors of colorectal cancer (CRC) are sleep difficulties and gastrointestinal symptoms. Among patients with various gastrointestinal (inflammatory) diseases, sleep quality has been related to gastrointestinal symptoms. For CRC survivors, this relation is unclear; therefore, we examined the association between sleep quality and quantity with gastrointestinal symptoms among CRC survivors.

Methods
CRC survivors registered in the Netherlands Cancer Registry—Southern Region diagnosed between 2000 and 2009 received a survey on sleep quality and quantity (Pittsburgh Sleep Quality Index) and gastrointestinal symptoms (European Organisation for Research and Treatment of Cancer, Quality of Life Questionnaire-Colorectal 38, EORTC QLQ-CR38) in 2014 (≥ 4 years after diagnosis). Secondary cross-sectional data analyses related sleep quality and quantity separately with gastrointestinal symptoms by means of logistic regression analyses.

Results
In total, 1233 CRC survivors were included, of which 15% reported poor sleep quality. The least often reported gastrointestinal symptom was pain in the buttocks (15.1%) and most often reported was bloating (29.2%). CRC survivors with poor sleep quality were more likely to report gastrointestinal symptoms (p’s < 0.01). Survivors who slept < 6 h were more likely to report symptoms of bloating or flatulence, whereas survivors who slept 6–7 h reported more problems with indigestion.

Conclusions
Worse sleep quality and short sleep duration were associated with higher occurrence of gastrointestinal symptoms.

Implications for cancer survivors
Understanding the interplay between sleep quality and gastrointestinal symptoms and underlying mechanisms adds to better aftercare and perhaps reduction of residual gastrointestinal symptoms in CRC survivors by improving sleep quality.
How does a move towards a coaching approach impact the delivery of written feedback in undergraduate clinical education?
Authors: Roberts Amanda , Jellicoe Mark , Fox Kathryn 
Published: September 2021

AbstractFeedback uptake relies on interactions between learners and educators Winstone (Educ Psychol 52: 17–37, 2017). Feedback that coaches using a feedforward approach, is considered to be more personal and emotionally literate Bussey (Bull R Coll Surg Engl 99: 180–182, 2017), Hattie (Rev Educ Res 77: 81–112, 2007). Many modes of feedback are employed in clinical teaching environments, however, written feedback is particularly important, as a component of feedback discourse, as significant time may elapse before a similar clinical situation is encountered. In practice, time constraints often result in brief or descriptive written feedback rather than longer coaching feedback. This study aimed to explore whether a change in ethos and staff development would encourage clinical dental tutors to utilise a coaching approach in their written feedback. Across two time-points, written feedback was categorised into either descriptive, evaluative or coaching approaches. Cross-sections of data from 2017 to 2019 were examined to determine whether changes in practice were noted and whether there were any alterations in the affective nature of the language used. Feedback moved significantly towards coaching and away from a descriptive approach. A shift towards the use of more positive language was seen overall, although this was solely driven by a change in the evaluative feedback category. Descriptive feedback generally used neutral language with coaching feedback using marginally more positive language. Both categories employed significantly lower levels of affective language than evaluative feedback. These data indicate a move towards feedback approaches and language that may support increased uptake and utilisation of feedback.
Multiprong control of glioblastoma multiforme invasiveness: blockade of pro-inflammatory signaling, anti-angiogenesis, and homeostasis restoration
Authors: Bazan Nicolas G. , Reid Madigan M. , Flores Valerie A. Cruz , Gallo Juan E. , Lewis William , Belayev Ludmila 
Published: September 2021

AbstractGlioblastoma multiforme (GBM) is the most invasive type of glial tumor with poor overall survival, despite advances in surgical resection, chemotherapy, and radiation. One of the main challenges in treating GBM is related to the tumor’s location, complex and heterogeneous biology, and high invasiveness. To meet the demand for oxygen and nutrients, growing tumors induce new blood vessels growth. Antibodies directed against vascular endothelial growth factor (VEGF), which promotes angiogenesis, have been developed to limit tumor growth. Bevacizumab (Avastin), an anti-VEGF monoclonal antibody, is the first approved angiogenesis inhibitor with therapeutic promise. However, it has limited efficacy, likely due to adaptive mutations in GBM, leading to overall survival compared to the standard of care in GBM patients. Molecular connections between angiogenesis, inflammation, oxidative stress pathways, and the development of gliomas have been recognized. Improvement in treatment outcomes for patients with GBM requires a multifaceted approach due to the converging dysregulation of signaling pathways. While most GBM clinical trials focus on “anti-angiogenic” modalities, stimulating inflammation resolution is a novel host-centric therapeutic avenue. The selective therapeutic possibilities for targeting the tumor microenvironment, specifically angiogenic and inflammatory pathways expand. So, a combination of agents aiming to interfere with several mechanisms might be beneficial to improve outcomes. Our approach might also be combined with other therapies to enhance sustained effectiveness. Here, we discuss Suramab (anti-angiogenic), LAU-0901 (a platelet-activating factor receptor antagonist), Elovanoid (ELV; a novel lipid mediator), and their combination as potential alternatives to contain GBM growth and invasiveness.
Polyplexes of retinoic acid: an in vitro study of complex nanostructures against colorectal cancer cell line (HCT-15)
Authors: Ture Narayan , Desai Drashti , Shende Pravin 
Published: September 2021

AbstractDespite recent advances in the treatment of human colon cancer, the chemotherapeutic efficacy against colon cancer is still unsatisfactory. The complexity in colorectal cancer treatment leads to new research in combination therapy to overcome multidrug resistance in cancer and increase apoptosis. The objective of the present research work was to develop polyplexes for co-delivery of plasmid DNA with retinoic acid against colorectal cancer cell line (HCT-15). Plain polyplexes were prepared using chitosan and hyaluronic acid solution (0.1% w/v), whereas retinoic acid polyplexes were prepared using ethanol: water (1:9 v/v) system. The particle size was observed in the order of chitosan solution > blank polyplex > retinoic acid-loaded polyplex. Encapsulation efficiency of retinoic acid was found to be 81.51 ± 4.33% for retinoic acid-loaded polyplex formulation. The drug release was observed to be in a controlled pattern with 72.23 ± 1.32% release of retenoic acid from polyplex formulation. Cell line studies of the formulation displayed better cell inhibition and low cytotoxicity for the retinoic acid-loaded polyplexes in comparison to pure retinoic acid, thus demonstrating better potential action against colorectal cancer cell line HCT-15. Retinoic acid-loaded polyplexes indicated higher potential for the delivery of the active whereas the cell line studies displayed the efficacy of the formulation against colorectal cancer cell line HCT-15.
The Effects of Parental Labor Migration on Children’s Mental Health in Rural China
Authors: Jiang Hechao , Duan Taixiang , Wang Fang 
Published: September 2021

AbstractUtilizing data from the China Education Panel Survey, we investigated the effects of parental migration and its duration on children’s mental health in rural China. We obtained a sample of 3830 rural children, comprising 2769 children who lived with both parents, 512 children whose one parent had migrated, and 549 children whose both parents had migrated. The results of multiple regression and propensity score matching showed that absence of both parents was negatively correlated to children’s mental health, with the migration of one parent having little effect. The negative effects related to parental labor migration became more apparent when we considered the duration of parents’ migration. Compared with children whose parents were not absent, children who had been left behind for less than one year and those who had been left behind for more than one year both displayed poorer mental health. These findings urge us to infer that family arrangements have an important influence on children’s psychological health. The findings also showed girls’ mental health more likely to be affected than that of boys, which implied a gender difference in the impacts of parental migration. Research and policy implications are discussed.
Ventrikuläre Arrhythmien bei obstruktiver und zentraler Schlafapnoe
Authors: Brandts Paul , Arzt Michael , Fisser Christoph 
Published: September 2021

Zusammenfassung
Hintergrund
Ventrikuläre Arrhythmien treten mit einer hohen Prävalenz auf und sind mit einer hohen Morbidität und Mortalität assoziiert. Sowohl die obstruktive (OSA) als auch die zentrale (ZSA) Schlafapnoe können auf Grund ihrer Pathophysiologie zu vermehrten ventrikulären Arrhythmien beitragen.

Ziel
Dieser Artikel soll die komplexen Zusammenhänge und Erkenntnisse jüngster Forschungen bezüglich schlafbezogenen Atmungsstörungen (SBAS) und ventrikulärer Arrhythmien und deren Therapiemöglichkeiten beleuchten.

Material und Methoden
Es erfolgte eine Literaturrecherche basierend auf prospektiven, retrospektiven, klinischen und experimentellen Studien sowie Reviews, Metaanalysen und aktuellen Leitlinien, die seit 2014 in der Medline-Datenbank gelistet wurden.

Ergebnisse
Es besteht ein bidirektionaler Zusammenhang zwischen der SBAS und ventrikulären Arrhythmien. Intermittierende Hypoxie, oxidativer Stress, wiederkehrende Arousals, intrathorakale Druckschwankungen und kardiales Remodeling tragen im Rahmen der SBAS zu einer erhöhten ventrikulären Arrhythmieneigung bei. Der Schweregrad der OSA, gemessen mittels Apnoe-Hypopnoe-Index, ist mit der Prävalenz ventrikulärer Arrhythmien assoziiert. Ähnliche Ergebnisse liegen für Patienten mit ZSA und Herzinsuffizienz vor. Studien zu ventrikulären Arrhythmien bei ZSA-Patienten ohne Herzinsuffizienz fehlen. Eine Positivdrucktherapie (PAP) bei OSA- oder ZSA-Patienten führte in verschiedenen Studien zu einer reduzierten Anzahl an ventrikulären Arrhythmien. Dieser Zusammenhang konnte jedoch nicht in allen Studien bestätigt werden. Ventrikuläre Arrhythmien treten bei der OSA gehäuft nachts auf, bei der ZSA gleichmäßig über den Tag verteilt.

Diskussion
Bisherige Studien weisen einen Zusammenhang zwischen der OSA bzw. der ZSA und ventrikulären Arrhythmien trotz unterschiedlicher Pathophysiologie nach. Hinsichtlich des Effektes der PAP auf ventrikuläre Arrhythmien bei Patienten mit OSA und ZSA sind weitere Studien erforderlich.
The Glasgow Prognostic Score Before Curative Resection May Predict Postoperative Complications in Patients with Gastric Cancer
Authors: Shimoda Yota , Fujikawa Hirohito , Komori Keisuke , Watanabe Hayato , Takahashi Kosuke , Kano Kazuki , Yamada Takanobu , Shiozawa Manabu , Morinaga Soichiro , Katsumata Kenji , Tsuchida Akihiko , Ogata Takashi , Oshima Takashi 
Published: September 2021

Abstract
Purpose
Despite improvements in surgical techniques and devices and perioperative care of gastric cancer (GC), the rate of postoperative complications still has not decreased. If patients at high risk for postoperative complications could be identified early using biomarkers, these complications might be reduced. In this study, we investigated usefulness of the preoperative Glasgow Prognostic Score (GPS) as a predictive factor for complications after surgery in patients with stage II/III GC.

Methods
This study retrospectively analyzed the outcomes of 424 patients who underwent curative surgery for pathological stage II/III GC from February 2007 to July 2019 at a single center. The GPS was assessed within 4 days before surgery. To identify independent risk factors for postoperative complications, univariate and multivariate analyses were performed using a Cox proportional hazards model.

Results
The numbers of patients with a GPS of 0, 1, and 2 were 357, 55, and 12, respectively. The rate of complications after surgery was significantly higher among patients with a GPS of 1 or 2 than among patients with a GPS of 0 (p = 0.008). Multivariate analysis identified a GPS of 1 or 2 as an independent predictive factor for postoperative complications (p = 0.037).

Conclusion
The preoperative GPS may be a useful predictive factor for postoperative complications in patients with stage II/III GC. Being aware of the risk of complications after surgery as indicated by the GPS before surgery may promote safe and minimally invasive surgery that we expect will improve outcomes in patients with a GPS of 1 or 2.
Effect of Post-Weld Heat Treatment Conditions on Mechanical Properties, Microstructures and Nonductile Fracture Behavior of SA508 Gr.1a Thick Weldments
Authors: Lee Junsang , Kim Jong Sung , Lee Bongsang , Cho Sungwoo , Kwon Dongil , Kim Jong-hyoung 
Published: September 2021

AbstractThis study analyzes the effects of post-weld heat treatment (PWHT) on the mechanical properties and microstructures of SA-508 Gr.1a welds and proposes a new PWHT exemption criterion based on nonductile fracture evaluation considering welding residual stress. The welding coupons were prepared with submerged-arc welding, gas-tungsten arc welding, and shielded-metal arc welding, using ferritic steel, SA-508 Gr.1a. The microstructure of the heat-affected zone (HAZ) was analyzed using optical microscopy, electron-back-scatter diffraction and Vickers hardness testing. The mechanical properties of the welds were evaluated by uniaxial tensile test, transverse side bend test, Charpy V-notch impact test and side bend test. Bainite and ferrite structures formed mainly in the HAZ, and the grain size became coarser with proximity to the surface and fusion line. The mechanical properties did not depend strongly on PWHT, weldment thickness or welding techniques, and they satisfied the welding procedure qualification test specified in the ASME Boiler & Pressure Vessel code. Welding residual stresses were considered in assessing structural integrity using nonductile fracture evaluation. A margin of safety against nonductile fracture with residual stress was calculated for Korean Standard Nuclear Power Plant steam-generator welds, using its design parameters and operating conditions, and this safety margin is suggested as an acceptance criterion for residual stress for exemption from PWHT.
Graphic abstract
Use and self-perceived effects of social media before and after the COVID-19 outbreak: a cross-national study
Authors: Thygesen Hilde , Bonsaksen Tore , Schoultz Mariyana , Ruffolo Mary , Leung Janni , Price Daicia , Geirdal Amy Østertun 
Published: September 2021

AbstractTo (i) examine the use of social media before and after the COVID-19 outbreak; (ii) examine the self-perceived impact of social media before and after the outbreak; and (iii) examine whether the self-perceived impacts of social media after the outbreak varied by levels of mental health. A cross-national online survey was conducted in Norway, UK, USA and Australia. Participants (n = 3810) reported which social media they used, how frequently they used them before and after the COVID-19 outbreak, and the degree to which they felt social media contributed to a range of outcomes. The participants also completed the 12-item General Health Questionnaire. The data were analyzed by chi-square tests and multiple linear regression analysis. Social media were used more frequently after the pandemic outbreak than compared to before the outbreak. Self-perceived effects from using social media increased after the COVID-19 outbreak, and in particular stress and concern for own and others’ health. Emotional distress was associated with being more affected from using social media, in particular in terms of stress and concern for own or others’ health. The use of social media has increased during the coronavirus outbreak, as well as its impacts on people. In particular, the participants reported more stress and health concerns attributed to social media use after the COVID-19 outbreak. People with poor mental health appear to be particularly vulnerable to experiencing more stress and concern related to their use of social media.
Landslide susceptibility in the Belt and Road Countries: continental step of a multi-scale approach
Authors: Titti Giacomo , Borgatti Lisa , Zou Qiang , Cui Peng , Pasuto Alessandro 
Published: September 2021

AbstractThe Belt and Road Initiative is a collaboration project launched by the Chinese Government to connect more than 65 countries all over the word by developing infrastructures, facilities, and support collaborations among involved Countries. The Silk Road Disaster Risk Reduction is a sub-project of the Belt and Road Initiative focused on mitigation and prevention of natural risks in the involved countries. In this context, this work presents a method to approach landslide susceptibility zoning on a continental scale that takes into account the limitations due to the completeness of landslide inventories and the scale and data quality of causal factors. A first attempt to produce a pixel-based statistical susceptibility map is described. All the data and software used in this work are open and open source. The landslide susceptibility zoning has been carried out in south-Asia using the NASA-COOLR landslide dataset through the Weight of Evidence method and it has been evaluated and validated by means of the ROC analysis. The results reveal a good prediction capacity and highlights that slope, relative relief and annual precipitation are the causative factors that play a major role in predisposing slope instability in the study area. Based on them, the method will be applied to the rest of the Belt and Road Countries.