bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological Analysis of the Effectiveness of Rabies Post-Exposure Prophylaxis in the Russian Federation (2001–2018)
Authors: Nashatyreva D. N. , Botvinkin A. D. , Poleshchuk E. M. , Sidorov G. N. , Rudakov N. V. 
Published: September 2021

Relevance. Post-exposure prophylaxis (PEP) is the most effective method for reducing the morbidity and mortality of human rabies. Since 2000, in Russia, domestically produced cultural purified and concentrated rabies vaccine (COCAV) and equine immunoglobulin (AIG) are used as the main drugs for PEP.Aims. To assess the epidemiological effectiveness of post-exposure rabies prophylaxis and possible causes of failure in the Russian Federation in 2001–2018.Materials & methods. A comprehensive retrospective epidemiological study of 167 cases of rabies in humans and PEP statistics in the Russian Federation was carried out. To test the hypotheses about the relationship between PEP failures and risk factors, namely (gender, age, place of residence of the sick, nature of the injuries received, source of infection), two main comparison groups were formed: «vaccinated» (n = 28) and «not vaccinated» (n = 139). In addition, we compared the groups who received PEP correctly and those vaccinated with violations of instructions. The failure rate was assessed in relation to the total number of vaccinated and the number of vaccinated after contact with rabid animals.Results.During the analyzed period, the incidence of human rabies decreased from 0.015 to 0.0013 per 100 thousand population. Of the patients, 83.2% did not receive PEP (did not apply, vaccinations were not prescribed, refused). In the group «vaccinated» in 53.6% (n = 15), the schemes of PEP prescribing and administering were violated, including in 35.7% (n = 10) of cases AIG was not administered. The rest 46.4% (n = 13), received vaccinations in accordance with the instructions. Before the end of the vaccination course, 85.7% (n = 24) fell ill; the rest fell ill with an incubation period of more than three months. Only one person received AIG and all 6 vaccine injections. The group «vaccinated» differed from the group «not vaccinated» by a higher frequency of category III injuries (χ2 = 9.99, p = 0.019) and injuries caused by wild animals, especially wolves (χ2 = 22.24, p < 0.001).Conclusions.Among people who developed rabies in 2001–2018, 16.8% received PEP. The proportion of the number of cases and the total number of those who received PEP was 1: 240.0 thousand. The failure rate of PEP after contact with rabid animals was 0.03% (excluding the nature of the contact and the animal species). More than 70% of all failures are associated with wolf and fox bites, more than 85% with category III injuries.
Acellular Pertussis Vaccine from Antigens of Freshly Isolated and Vaccine Strains of Bordetella pertussis with Different Genotypic Characteristics
Authors: Zaitsev E. M. , Bazhanova I. G. , Britsina M. V. , Mertsalova N. U. , Ozeretskovskaya M. N. 
Published: September 2021

Relevance. The development of effective and safe vaccines for pertussis prevention remains an urgent public health challenge.Aim. To study the protective activity and safety of acellular pertussis vaccine (AcPV) containing a complex of protective antigens from freshly isolated and vaccine strains of Bordetella pertussis.Materials and methods. Freshly isolated (No. 287, and No. 317) and vaccine (No. 305 and No. 475) B. pertussis strains with «non-vaccine» and «vaccine» allelic variants of the pertussis toxin (PT) subunit A gene, the PT promoter gene, the pertactin gene, the fimbria 2 gene, and the fimbria 3 gene strains were used for the production of AcPV.Results. All the studied variants of AcPV were harmless in the test of changes in the body weight of mice and sensitivity to histamine. The protective activity of AcPV3 (strains No. 287, No. 317 and No. 305) and AcPV1 (strains No. 287, No. 305 and No. 475) was higher than that of AcPV2 (strains No. 317, No. 305, and No. 475). IgG antibody titers to PT were also higher in mice immunized with AcPV1 and AcPV3.Conclusion. The higher protective activity of AcPV3 and AcPV1 may be associated with the genotype of strain No. 287, which has a ptxP3 PT promoter and is characterized by an increased level of PT production and high virulence. The most promising for further preclinical and clinical studies is AcPV3, which contains 2/3 of the antigens of the dominant «non-vaccine» genotype and 1/3 of the «vaccine» genotype, corresponding to the genes of PT, pertactin and fimbria to the currently circulating B. pertussis strains.
Assessment of the State of Anti-Measles Immunity in Medicine Personnel of a Children's Hospital
Authors: Tkachenko T. G. , Dmitriev A. V. , Gudkov R. A. , Fedina N. V. 
Published: September 2021

RelevanceThe epidemiological disadvantage of measles in developed countries reflects the weakening of herd immunity and is caused, first of all, a change in society's attitude to vaccine prevention and the risks of infectious diseases, which requires a revision of the prevention strategyAim:assessment of measles immunity in employees of the regional multidisciplinary children's hospital.Materials & Methods.365 employees were examined at the same time in 2019 on the basis of the regional children's hospital. Investigation of the intensity of immunity to measles by ELISA using the VectoKor-IgG test system (Vector-Best, Russia). The surveyed were divided into 4 age groups (20–29, 30–39, 40–49 and 50 years and older). Statistical processing was carried out using the χ2 test and Spearman's rank correlation.Results.63% of the examined had a protective titer of antibodies. The least protected were medical workers under the age of 40, especially up to 30 years old, with a share of immune persons of 30%. In older age groups, the proportion of seropositive persons was 80.9%. The age of the employees and the levels of measles immunity were highly correlated (r = 0.72). There was no statistically significant effect on the state of measles immunity of professional status, the presence of documentary evidence of vaccination.Conclusions.Thus, the results of the conducted study indicate a high epidemiological risk of measles in medical institutions and when applying to them. The worst indicators of protective immunity were found among young employees. It is advisable to continue serological monitoring in medical institutions, organized vaccination of seronegative individuals, as well as conduct cooperative research
Impact of a Student-teach-student Model for IPE Between Pharmacists and Dermatologists on Student Knowledge and Attitude
Authors: Johnston Cassidy M. , Pan Huixian , Sorrells Robert , Brand-Eubanks Damianne , Darst Emily , Scott Michael J. 
Published: September 2021

Introduction: The effective delivery of patient care is a complex venture, often requiring efficient collaboration among varied healthcare professions. Not surprisingly, research continues to indicate collaboration between these diverse professionals can be challenging. Early exposure of health professions students to interprofessional education (IPE) offers a promising way to improve this collaboration and, in turn, improve patient care and service delivery.
Objectives: This study examines the impact of an innovative IPE cocurricular event on knowledge, understanding, and attitudes, regarding future healthcare delivery between medical and pharmacy students.
Method: Students developed and conducted an IPE cocurricular event involving medical students of a dermatology-interest club, and pharmacy students of a compounding-interest club. Medical students introduced a patient case, delivered in a standardized-patient format. This was followed by a pharmacy student presentation representing compounding the prescriptions needed for the patient case and writing accurate prescriptions. Following both presentations, students from each program were paired. Each interprofessional pair then communicated and compounded two medications for the case, working collaboratively. Pre- and post-questionnaires were designed with rating scales and open-ended questions for data collection.
Results: Both parametric and nonparametric tests revealed significant differences between the pretests and posttests. There was no significant difference in responding between the groups. Inspection of the open-ended questions revealed changes in attitudes regarding collaboration and learning.
Conclusions: This study found students of both professions reported significant improvements in their level of knowledge, understanding, and interest in interprofessional collaboration. The open-ended questions revealed both groups of students began the event with different expectations regarding cooperation and interprofessional activities but left the session with very similar perspectives. By including similar IPE activities in early healthcare education, medical students will gain an understanding of the knowledge, skills, and services that a compounding pharmacist can offer in personalized patient care, and pharmacy students will acquire clinical reasoning based on patient presentations. Both factors promote collaboration between professions and ultimately show promise in improving outcomes in patient care.
TRADEMARK REGISTRATION IN BRAZIL, THE UNITED STATES AND PORTUGAL
Authors: Silva Neto Ana Teresa , Leitão Suzana Russo 
Published: September 2021

This article aims to understand, analyze and compare the procedures adopted in Brazil, the United States and Portugal to register a trademark. For this purpose, bibliographic research was carried out in the Web of Science and documentary research into the three official institutions of trademark registration, namely: INPI(Brazil), USPTO(United States) and INPI(Portugal). In order to understand the adopted procedures, a simulation of the trademark application was made in the e-Marcas (Brazil), TEAS (USA) and InpiOnline (Portugal) systems.
In terms of navigability, the INPI (Portugal) InpiOnline System is the easiest to navigate and is the only one that offers the "Trademark on the Spot" service on its Portal, which allows for the immediate acquisition of a trademark without the need to go through the trademark application process. On the partnership issue, the USPTO (United States) has a support network with the Patent and Trademark Resource Centers (PTRC), which are part of the national network of public, state, and academic libraries designated to support the public with trademark and patent assistance. Among the main points in common, the following were identified: the availability of online systems for applying for trademark registration; the ease of conducting prior search in proprietary systems, and the use of the Nice classification to classify goods and services. Among the main differences are the estimated period to obtain the granting of the trademark registration; the types of trademarks allowed in each legislation; and the values of the fees to apply for a trademark registration.
Problems of Higher School Didactics: Uncut Pages
Authors: Petruneva R. M. , Vasilyeva V. D. , Petruneva Y. V. 
Published: September 2021

Higher education today is not going through the best of times: decisions taken in the educational process at various levels (Federal Laws “On Education in the Russian Federation” of 29.12.2012 No 273-FZ and “On Amendments to the Federal Law “On Education in the Russian Federation” on the education of students” of 31.07.2020 No 304-FZ, Federal State Educational Standards of Higher Education, etc.), related to global changes taking place in society and in the world in recent decades, were made without careful didactic study. This cannot help to improve the quality of specialist training. Teachers are forced to work “by trial and error”, producing countless didactic documents. At present, identification of didactic problems in the educational process of higher educational institutions is extremely relevant due to the expansion of the field of didactic research in higher school pedagogy.The aim of the authors was to analyze some of the most relevant didactic phenomena in the digital reality that have not yet received proper understanding. As a result of the analysis, some important didactic problems of higher education are identified, concerning goal-setting, compliance of teaching with classical didactic principles, organization of distance learning in electronic informational and educational environment, mixed and project-based learning. The article also dwells on psychological problems of Internet content assimilation and “non-contact” interaction between the subjects of the educational process, etc. The most promising areas of didactic research in higher education, including the development of interdisciplinary contacts, are highlighted.
Evaluation of Teacher Training Needs in Engineering Pedagogy
Authors: Gormaz-Lobos D. , Galarce-Miranda C. , Hortsch H. 
Published: September 2021

In European countries, primarily in German-speaking countries, first of all, in Germany (Dresden), the concept of engineering pedagogy (EP) has existed for more than 70 years. In Eastern Europe, particularly in the Russian Federation, the tradition of EP has more than 20 years and shows an extensive network of universities actively participating in IGIP (International Society of Engineering Pedagogy). Several universities offer the IGIP curricula and work on various projects related to majoring in engineering education and pedagogy in Russian Higher Education Institutions. In Spanish-speaking countries the concept of EP is relatively recent. Particularly, since 2014, the Technical University of Dresden (TU Dresden) works in cooperation with Chilean universities to strengthen engineering pedagogy and education in the university context. This goal was concretized through two cooperation projects “Engineering Didactics at Chilean Universities” (PEDING-Project) and “Strengthening engineering training at Chilean universities through practice partner-ships” (STING-Project), both financially supported by DAAD. The main goal of this paper is to present the results of a survey about teaching needs in engineering pedagogy in a Chilean university. In general, the results showed the high level of interest and motivation that a training course on engineering pedagogy specifically oriented for the academic staff of engineering faculties may have. The project was led by the International Center of Engineering Education (CIEI) at the University of Talca (Chile) under the pedagogical support of the TU Dresden (Germany).
Sonographic evaluation of intra-abdominal organs in children with familial Mediterranean fever
Authors: SÖNMEZGÖZ Ergün , SÖNMEZGÖZ Fitnet 
Published: September 2021

Objective: The reticuloendothelial system is rarely assessed in patients with familial Mediterranean fever (FMF). We aimed to evaluate the size of the liver and spleen by ultrasonography in children and adolescents with FMF and compare it to their healthy peers.
Material and Method: Patient data were evaluated by height, weight, and age and compared with those of healthy controls.
Results: A total of 86 children with FMF diagnosed using the Turkish Pediatric Criteria and 54 healthy children were included. The extent of splenomegaly was 27.9% in the FMF group. The mean spleen length was 99.84±17.4 mm in patients and 93.44+15.49 mm in controls (p=0.03). The mean liver length was 122.61±17.4 mm in patients and 117.71±16.04 mm in controls (p=0.104). FMF appears to affect spleen length independently of anthropometric data (t=2.182; p=0.031). Splenomegaly was accompanied by the M694V (32.55%, n=17) and E148Q (3.4%, n=3) mutations.
Conclusion: FMF affects spleen length independently of anthropometric data. Splenomegaly may reflect subclinical inflammatory activity in FMF patients in remission. Spleen size can serve as a marker of subclinical inflammation during remission.
Comparison of short-term results of open and laparoscopic surgery in gastric cancer at a new regional hospital: a single surgeon experience
Authors: GOKSOY Beslen , KİYAK Mevlut , YILMAZ Gökhan , AZAMAT İbrahim , ERTORUL Didem , İNANÇ Ömer , ARICAN Çiğdem , CİL Ibrahim , BİTİRİM Mehmet 
Published: September 2021

Aim
To compare the short-term results of open and laparoscopic gastrectomy in gastric cancer surgery.
Material and Method
From 15 May 2018 to 28 June 2021, patients who underwent open and laparoscopic gastrectomy for gastric cancer by a single surgeon between were retrospectively analyzed from a prospectively maintained database. Patients were compared in terms of early intraoperative and postoperative outcomes. Both surgical methods were compared in terms of early intraoperative and postoperative outcomes.
Results
A total of 34 patients (open n = 23, laparoscopic n = 11) were included in the study. While the mean number of lymph nodes was similar between the groups, more metastatic lymph nodes and more advanced disease were detected in the open group (p = 0.007, p = 0.002, respectively). According to tumor location, patients who underwent laparoscopic gastrectomy were more distally located (p = 0.01). The mean operative time was shorter in the open group (171.5 min and 206 min, p = 0.006, respectively), while the estimated blood loss was less in the laparoscopic group (158.2 mL vs 186.7 mL, p = 0.003). Four patients (17.4%) in the open group and two patients (18%) in the laparoscopic group had at least Clavien-Dindo grade III complications (p=0.96). Earlier gas output was seen in the laparoscopic group (p = 0.002), while other postoperative outcomes were similar between the groups. Mean follow-up time was longer in the open group (13.4 months and 7.6 months, respectively, p = 0.004).
Conclusion
Until sufficient experience is reached in laparoscopic gastrectomy, choosing earlier stage and distally located tumors is a safe method with postoperative results similar to open gastrectomy.
Evaluation of the relationship between disease activity and serum bilirubin, albumin, and uric acid levels in Crohn's disease
Authors: BEDİR KESER Gizem , EKMEN Nergis 
Published: September 2021

Objective: Oxidative stress and antioxidant deficiency play key roles in the pathogenesis of gastrointestinal damage associated with Crohn's disease (CD). Serum bilirubin, uric acid (UA) and albumin are non-enzymatic antioxidants that play a role in oxidative stress control. In this study, it was aimed to evaluate the change in serum bilirubin, UA and albumin levels due to disease activity.
Material and Method: This study was designed as a single-center, cross-sectional and retrospective. The clinical and demographic data of the patients, disease activity, as well as serum albumin, UA, and bilirubin values were recorded from the hospital database. Study variables were statistically analyzed between patient and control groups based on disease activity.
Results: A total of 234 people, 114 with CD and 120 with controls, were included in the study. Total bilirubin, direct bilirubin and albumin levels were found to be significantly lower in the CD than in the health control (p=0.045, p
Evaluation of colonoscopic findings in patients undergoing colonoscopy due to positive fecal occult blood test: a single center experience
Authors: DÜZENLİ Tolga , KİYAK Mevlut 
Published: September 2021

Aim: Fecal occult blood test is used in the early diagnosis of colorectal cancers. We aimed to evaluate the colonoscopic and pathological findings of patients who underwent colonoscopy due to positive fecal occult blood test in a tertiary center.
Material and Method: Patients who had a positive fecal occult blood test and referred to the xxx Training and Research Hospital endoscopy unit for colonoscopy were included in this study. Age, gender, colonoscopic findings and pathology results of the patients were recorded. Statistical analyzes were performed with SPSS.
Results: Two hundred and twenty three patients were included in the current study. Of the patients, 101 (45.3%) were male and 122 (54.7%) were female, with a mean age of 53.2 (18-90 years). Endoscopic diagnoses were as 49 (22%) polyps, 13 (5.8%) colon cancer, 4 (1.8%) inflammatory bowel disease, 15 (6.7%) diverticulum, 63 (28.3%) perianal disease, 79 (35.4%) normal colonoscopic findings. Pathological features of colon polyps were as; tubular adenoma in 51%, tubulovillous adenoma in 18.4%, serrated adenoma in 2%, and hyperplastic polyp in 28.6%. Colonoscopy findings of patients according to age groups (over and under 50 years of age); the incidence of polyps (p=0.01) and diverticulum (p=0.001) were significantly higher in patients older than 50 years, while perianal diseases (p=0.031) and normal colonoscopic findings (p=0.008) were higher in patients younger than 50 years of age.
Conclusion: Colon pathology was detected in approximately 2/3 of the patients presenting with a positive fecal occult blood test. This test is an inexpensive, easily applicable method that helps to detect colon cancer and precursor lesions, as well as pathologies such as subclinical inflammatory bowel disease and diverticulum causing chronic blood loss.
ANALISIS DISHARMONISASI ANTARA ASSET FINANCING SERTA KEBIJAKAN PENGELOLAAN INDUSTRI PERTAMBANGAN TERHADAP PDRB DI PROVINSI LAMPUNG
Authors: Suwarto Suwarto , Japlani Ardiansyah , Monaitaria Abi Melin 
Published: September 2021

ABSTRAK Dalam rangka memanfaatkan kekayaan sumber daya alam tentunya diperlukan modal sebagai modal khususnya dari perbankan melalui asset financing. Penelitian ini bertujuan untuk mengetahui dan menganalisis. analisis disharmonisasi antara asset financing, kebijakan pengelolaan industri pertambangan terhadap PDRB di Lampung. Pembiayaan modal kerja dan pembiayaan investasi digunakan sebagai variabel independen. Sedangkan, dampak kebijakan kebijakan pengelolaan industri pertambangan menggunakan variabel dummy. Variabel independen dan variabel dummy tersebut dihubungkan dengan variabel dependen yaitu PDRB menggunakan metode regresi data panel dengan model Random Effect(REM) di Lampung. Hasil penelitian menunjukkan bahwa asset financing berpengaruh positif terhadap pertumbuhan ekonomi di Lampung, namun hanya pembiayaan modal kerja yang berpengaruh signifikan. Sementara itu, kebijakan kebijakan pengelolaan industri pertambangan terbukti memberikan pengaruh positif dan signifikan terhadap pertumbuhan ekonomi Lampung. Hasil penelitian ini diharapkan dapat bermanfaat bagi industri, pemerintah maupun regulator sebagai bahan evaluasi mengenai pengaruh asset financing dan kebijakan pengelolaan industri pertambangan terhadap PDRB provinsi Lampung. Kata kunci: Asset Financing, Kebijakan Pengelolaan Industri, PDRB, Lampung ABSTRACT In order to utilize the wealth of natural resources, of course, capital is needed as capital, especially from banks through asset financing. This study aims to determine and analyze. analysis of disharmony between asset financing, mining industry management policies against GDP in Lampung. Working capital financing and investment financing are used as independent variables. Meanwhile, the impact of the mining industry management policy uses a dummy variable. The independent variables and dummy variables are associated with the dependent variable, namely GRDP using the panel data regression method with the Random Effect (REM) model in Lampung. The results showed that asset financing had a positive effect on economic growth in Lampung, but only working capital financing had a significant effect. Meanwhile, the mining industry management policy has proven to have a positive and significant impact on Lampung's economic growth. The results of this study are expected to be useful for industry, government and regulators as an evaluation of the effect of asset financing and mining industry management policies on PDRB in Lampung province. Keywords: Asset Financing, Industrial Management Policy, GRDP, Lampung