bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marine bioinvasions: bivalve molluscs introduced in northeast Brazil
Authors: Lima Luan Lucas Cardoso , Passos Flávio Dias 
Published: February 2021

ABSTRACT: Invasive alien species are those that, once introduced from other environments, adapt, starting to reproduce and proliferate in places they did not previously inhabit. The introduction of exotic marine species as a result of anthropic activity, whether intentionally or not, is a process that has been remote for centuries, which makes it difficult to assess the impact of these activities, making studies that address the status of knowledge about such organisms always important. Thus, this research aims to gather information about bivalve molluscs introduced into marine ecosystems in northeastern Brazil, in addition to discussing the knowledge of this invasive fauna for the Northeast, Southeast and South regions of Brazil. For that there was a search for bibliography in 5 databases - SciELO, Web of Science, Google Scholar, ScienceResearch.com and I3N Brazil Database of the Horus Institute for Environmental Conservation and Development. Three invasive bivalves for the northeastern region of Brazil were counted. When compared to the South and Southeast regions, the Northeast presents a significant amount of research on the ecology of the species Isognomon bicolor (C. B. Adams, 1845) and Mytilopsis leucophaeata (Conrad, 1831), which is very important, because with these results it is possible to track and understand the pathways that make bioinvasions possible. Regarding Perna Perna (Linnaeus, 1758), although there is a discussion about its supposed introduction in Brazilian waters, the species can be considered invasive in Northeastern Brazil.
KEYWORDS: Invasive species, marine ecosystem, ecology.
Estudo do processo de biorremediação em solos impactados por derramamento de petróleo
Authors: Santos Amanda da Silva , Moreno Tertuliano Ferreira , Cavalcante Leon Carvalho Vieira , Amorim Eduardo Lucena Cavalcante de , Coêlho Dayana de Gusmão 
Published: February 2021

RESUMO: Devido ao derramamento de óleo no mar, que tem acontecido em diferentes cenários mundiais, as pesquisas têm-se voltado para processos de remediação que visam a degradação desse resíduo altamente tóxico e prejudicial para o meio ambiente. Os hidrocarbonetos, principais contaminantes, possuem características específicas e necessitam de tratamento adequado para serem descartados. O processo de biorremediação consiste no emprego de microrganismos para decompor contaminantes de interesse. O referente trabalho realizou uma revisão bibliográfica, a partir do levantamento de publicações sobre o tema e avaliou os diferentes métodos de remediação. As considerações finais após as análises realizadas, apontaram a biorremediação como melhor processo por se tratar de um método que não gera impactos negativos ao meio ambiente após sua aplicação e, por ser uma opção de tratamento viável, de baixo custo e que pode ser implantado em campo ou em sistemas fechados.
PALAVRAS-CHAVE: Biorremedição; Resíduos industriais; Meio ambiente.
Análise da atividade antioxidante e perfil fitoquímico da folha, caule e inflorescência de Senna splendida
Authors: Santos Cristina Alexandre , Cunha Amanda Lima , Costa Marília Layse Alves da , Almeida Anderson Soares de , Pavão Jessé Marques da Silva Júnior , Santos Aldenir Feitosa dos 
Published: February 2021

RESUMO: O objetivo da presente pesquisa foi avaliar o perfil fitoquímico e o potencial antioxidante das folhas, flores e caule da espécie Senna splendida. Para tanto foi feito o preparo dos extratos metanólicos e, por conseguinte realizou-se as análises de atividade antioxidante, pelo método DPPH, e estudo do perfil fitoquímico por meio da triagem fitoquímica e quantificação do teor de fenóis e flavonoides totais. Mediante a isto, foi possível verificar que o extrato da flor apresentou uma maior classe de metabólitos secundários. Por meio do teste de captura do radical DPPH foi observado que a flor também apresentou melhor capacidade de redução do DPPH com percentual médio de 70,48±0,92%. Entretanto, para os testes de quantificação de teor de fenóis totais e flavonoides o extrato das folhas apresentou melhores resultados, com 1036,13±131,4mgEAG/g de extrato e 96,25±1,87mgEQ/g de extrato. Portanto, é notável que o estudo sobre as propriedades medicinais para as diferentes partições de S. splendida é de grande relevância e destacando a capacidade dos diferentes extratos analisados em atuarem como inibidores de espécies radicalares e consequentemente serem utilizadas no tratamento ou combate a patologias.
PALAVRAS-CHAVE: Amemdoim bravo, Metabólitos secundário, Radicais livre.
Peptides contained in the composition of Laennec that contribute to the treatment of hyperferritinemia and iron overload disorders
Authors: Gromova O. A. , Torshin I. Yu. , Maksimov V. A. , Chuchalin A. G. , Zgoda V. G. , Gromov А. N. , Tikhonova O. V. 
Published: February 2021

Introduction. Hemosiderosis is a pathologic condition that accompanies liver, lung, and other organ diseases. Polypeptide-containing drug Laennec contributes to the elimination of excessive iron deposits in tissues.Aim. The study was aimed to identify peptides contained in the composition of the drug that take part in the regulation of iron homeostasis and correction of hemosiderosis and hyperferritinemia.Materials and Methods. The study of the drug composition was conducted with hybrid mass-spectrometry and modern methods of analysis of Big Data based on the topological approach to recognition.Results. The preparation contains 19 peptides that are potentially important for the regulation of iron homeostasis. These peptides help to treat the disorders of iron metabolism by regulating the levels of the main hormone of iron homeostasis hepcidin by reducing the synthesis of ferritin and by exhibiting anti-inflammatory and immunomodulatory effects.Conclusion. The identified peptides allowed the authors to describe the molecular mechanisms of the iron overload elimination that are known from experimental and clinical studies of the analyzed polypeptide drug.
Evaluation of the economic effect of biological therapy in patients with severe COVID-19 and cytokine storm
Authors: Frolov M. Yu. , Salasyuk A. S. , Rogov V. A. 
Published: February 2021

Aim. The study aimed to assess the economic effect of biological therapy with anti-interleukin (IL)-6 drugs: tocilizumab, olokizumab, and levilimab in patients with severe COVID-19 and cytokine storm.Materials and Methods. An assessment of the economic consequences of severe COVID-19 therapy was carried out using the cost of illness analysis in a model developed in Microsoft Excel 2016 (Microsoft, USA). The direct medical costs of providing care for COVID-19 were taken into account (ICU service, the cost of biological therapy, and the use of glucocorticosteroids (GC)). Data from a prospective, historical controlled CHIC study conducted in the Netherlands were used as a source of efficacy. A mathematical model has been developed for extrapolating the CHIC study results to clinical outcomes (transfer to mechanical ventilation, discharge from ICU, lethal outcome) and forecasting the costs of managing severe patients with COVID-19 in real clinical practice in the Russian Federation.Results. The reduction in the cost of therapy when the hypothesis of equal efficacy of tocilizumab, olokizumab, and levilimab is accepted by reducing the cost of drug therapy will be 1,251,698.99 rubles per 72 patients when comparing olokizumab with tocilizumab and 939,718.84 rubles per 72 patients when comparing olokizumab with levilimab.Conclusion. Anti-interleukin (IL)-6 drugs in combination with GC are an effective treatment option for moderate to severe patients with COVID-19 and cytokine storm symptoms. This group of drugs is indicated as the main one for the treatment of this condition.
Word Recognition and Reading Skills to Improve Reading Comprehension
Authors: Chamba Mayra Yadira , Ramirez-Avila Maria Rossana 
Published: February 2021

This research aimed at showing the influence of word recognition, and using skimming and scanning skills to improve reading comprehension. Participants were a group of 15 students whose ages ranged from 14 to 16. They had problems in reading comprehension and vocabulary. This action research was conducted at a private language institute. The instruments to collect data were pre- and post-surveys, pre- post-tests, learning logs, skimming and scanning forms, and an interview. They provided quantitative and qualitative information. Results showed that there was a statistically significant improvement in parts of speech knowledge from the pre- to the post-test. The result was an average improvement of 28.2% in student performance. Cohen’s d was calculated with a result of 1.09 which means there is impact in learning. There was also a steady improvement in skimming and scanning which was exemplified by the ability to correctly complete a form after reading texts. Lastly, students’ perspectives were positive to this innovation. Therefore, it is advisable to apply the same innovation with other learners in order to compare results of improvement of reading comprehension and overall proficiency.
The effects of topical steroid fears and concerns on patients with eczema: first TOPICOP© scale-based study in Saudi Arabia
Authors: Alharbi Abdulmajeed A. , Alhetheli Ghadah I. , Alqahtani Reema , Alshehri Mujahid 
Published: February 2021

<p><strong>Background:</strong> Topical corticosteroids (TCS) are the main treatment for eczema, which are often required for months (or years) to control the disease. Despite the well-known side effects of TCS, their efficacy and safety are well established when used appropriately. This study was conducted to assess the fears, concerns, and various practices of patients with eczema toward TCS in the Qassim region of Saudi Arabia.</p><p><strong>Methods:</strong> A cross-sectional survey-based study was conducted that targeted patients with eczema among all age groups and genders attending the dermatology outpatient clinics. There were no exclusions based on the type, severity, or duration of the disease.</p><p><strong>Results: </strong>A total of 105 patients with eczema were recruited for this study. It was revealed that 46.8% of participants stopped their treatment as soon as possible, which indicates immediate discontinuation of steroids after their eczema flares had subsided and improved. An interesting finding was that 38.3% of participants did not start their TCS treatment until the disease deteriorated rather than when flare-ups occurred.</p><p><strong>Conclusions:</strong> Exaggerated fears about TCS exist among patients with eczema and their care givers. This can result in non-adherence or wasting of many prescribed TCS preparations TCS. It is very important to understand and emphasize on the nature and extent of the prevalence of TCS fears to ensure that prompt, correct advice can be offered. Since dermatologists remain the most trusted source of information, there should be an emphasis on individual patient counseling and increased engagement in social media with pre-planned content.</p><p> </p>
Study of dietary pattern, and lifestyles among Type-2 diabetic patients
Authors: Anand Tripti , Das Bismay , Ali Tabasssum , Gupta Kalpana , Mohanty C 
Published: February 2021

In 21st century diabetes is one of the most challenging health problems. According to IDF diabetes Atlas 9th edition 2019, estimates approximately 463 million adults 20-79 years age group are with diabetes and by 2045, nearly 700 million adults is expected to have diabetes. Risk factors like age, sex family history, physical activity, BMI, dietary pattern were assessed to find their association with diabetes.A community based cross-sectional study was conducted during February to March 2019 among 100 respondents of 30-60 years of age group in Deoria and Karaundi Varanasi. Out of which 54 female and 46 male were interviewed by using pretested semi- structured interview. Pregnant women and patients with type 1 diabetes were excluded from the study.In the present study maximum 43% study subjects were in the age group of (40-50) years. Most of the patients were housewife that is 35%. Most common complication is ophthalmic like retinopathy, cataract and blur vision in 43% respondents and 54% respondents have diabetes since less than 5 years. By the reveal information about medical behavior out of the total respondents 24% were dependent upon insulin and remain 76% were not taking insulin. 65% respondents were regularly checking their blood glucose level and 35% were not checking regularly.The study shows that the positive significant associations between complications of diabetes and dietary pattern. Physical activity like regular exercise and walking, fiber rich diet, regular blood glucose checkup after 35 years are some of preventive measures which can control diabetes.
PRÁTICAS DE ENFERMEIROS E A INFLUÊNCIA SOCIOCULTURAL NA ADESÃO AO ALEITAMENTO MATERNO
Authors: Higashi Giovana Callegaro , Santos Sibeli Seefeld dos , Silva Rosielle Souza da , Jantsch Leonardo Bigolin , Soder Rafael Marcelo , Silva Luiz Anildo Anacleto da 
Published: February 2021

<p><strong>Objetivo:</strong> Descrever os saberes e práticas de enfermeiros da atenção primária em saúde quanto às intervenções para a promoção da amamentação. <strong>Método: </strong>Trata-se de um estudo qualitativo que utilizou referencial metodológico da Teoria Fundamentada nos Dados. Obteve-se a participação de nutrizes e enfermeiros, totalizando 19 pessoas. <strong> Resultados</strong>: durante o pré-natal as intervenções de incentivo ao aleitamento materno são desafiadoras uma vez que a influência por parte da rede de apoio, em especial das avós se sobrepõe as orientações prestadas pelos profissionais de saúde. As rotinas de puerpério imediato possuem relação com melhora adesão e que práticas como aleitamento na primeira hora e o alojamento conjunto favorecem a manutenção do aleitamento materno. <strong>Conclusão: </strong>Os enfermeiros reconhecem e realizam intervenções a adesão ao aleitamento materno desde o pré-natal ao puerpério, reconhecendo os principais desafios socioculturais impostos</p><p><strong>Descritores: </strong>Aleitamento Materno. Enfermagem. Saúde Materno-Infantil.</p><p> </p>
Resolución de los problemas de optimización con restricciones mediante los métodos de penalización y del Lagrangiano aumentado
Authors: Vázquez Mourazos Manuel 
Published: February 2021

En la resolución de los problemas de optimización con restricciones (también conocida con el nombre de programación matemática) se pueden establecer diversidad de algoritmos. Como la investigación en este campo es muy amplia, continuamente se están desarrollando nuevos métodos, cada vez más sofisticados, que permiten resolver este tipo de problemas.

En este artículo se presentarán los métodos de penalización. Estos son los más intuitivos y permiten mostrar una introducción dentro de la resolución de este tipo de problemas. Se estudiarán sus propiedades y, luego, se procederá a su deducción, interpretación y demostración de su convergencia. Finalmente, se presentará el método del Lagrangiano aumentado. Este es un método que mejora a los anteriores y con una mayor velocidad de convergencia. Así mismo, este artículo supone una introducción a los algoritmos de resolución de problemas de optimización con restricciones, mostrando una iniciación a los métodos numéricos empleados en la programación matemática.
Kardiyovasküler Hastalıklar için Yeni Epigenetik Belirteçler: Dairesel RNA'lar
Authors: ÖZBİLÜM Nil , YELKUVAN İzzet , BAYYURT Burcu 
Published: February 2021

Kardiyovasküler hastalık (KVH)’lar, dünyada yüksek morbidite ve mortaliteye neden olurlar. Son araştırmalar, KVH patogenezinde dairesel RNA (circRNA)'ların fonksiyonlarına odaklanmıştır. CircRNA'lar, kovalent olarak kapalı halkasal yapıya sahip, dokuya ve gelişimsel aşamaya özgü farklı ifade/ekspresyon profili olan kodlama yapmayan RNA (ncRNA)'lardır. Serbest uçlarınınolmaması, doğrusal transkriptlerle karşılaştırıldığında daha fazla stabilite sağladığından, circRNA’lar gelecekte ideal terapötik hedef adaylarıdır. Bu çalışmada circRNA'ların biyogenezi, biyolojik özellikleri ve KVH patogenezindeki etki mekanizmaları ile ifade düzeyleri derlenmiştir. Yapılan çalışmalar circRNA'ların KVH'nin ilerlemesinde yakından rol oynadığını ve KVH için umut verici biyobelirteçler olabileceğini doğrulamıştır. Bu bulgular gelecekte KVH'nin önlenmesi, teşhisi ve terapötik müdahalesi için yeni bir yol sağlayabilir.
Long-term effects of shade and input levels on coffee yields in the Pacific region of Nicaragua
Authors: LÓPEZ-SAMPSON Arlene , SEPÚLVEDA Norvin , BARRIOS Mirna , SOMARRIBA Eduardo , MUNGUÍA Rodolfo , MORAGA Pedro , PONCE Alejandro , OROZCO-AGUILAR Luis , NAVARRETE Elvin , NAVARRETE Ledis 
Published: February 2021

The suitability and profitability of coffee cultivation in Central America are at risk due to pest and disease outbreaks, price fluctuations and climate change. Proper shading is claimed to be one of the most promising practices to seek sustainability and better adapt coffee cultivation to climate change in marginal areas. This study recorded and compared coffee cherry yields over a ten-year period from shaded coffee (N-fixing-trees and timber trees) agroforestry systems under different management regimes (conventional vs. organic) in a suboptimal site. Significant differences in production were detected between conventional inputs vs. combination of organic inputs and shade types in some years of the evaluation period. Full-sun cultivation under intensive management was the most productive system for coffee yields, followed by shaded systems under timber trees. Interestingly, and regardless of management systems (intensive conventional or intensive organic) the worst combinations in terms of coffee yield were shaded systems under leguminous species (Inga laurina (Sw.) Willd. + Simarouba glauca DC.). Across all experimental plots, the timber species Simarouba glauca and Tabebuia rosea (Bertol.) DC. grew well, reaching a mean annual increment in diameter of 2.5-3.3 cm/year (age 12 years). Average gross revenues were higher in full-sun and timber-shaded agroforestry systems. Overall, intensive management regimes were the most expensive cultivation system to run but also the best in terms of coffee yield performance.
Un cadre d'évaluation de la vulnérabilité écologique des forêts dans les fronts de déforestation tropicaux à partir de l'évaluation de la dégradation des forêts dans une approche paysagère : études de cas au Brésil et Vietnam
Authors: BOURGOIN Clément 
Published: February 2021

La conservation du couvert forestier tropical est essentielle pour assurer la fourniture durable de services écosystémiques. Cependant, l'accroissement de la population, la demande de produits agricoles et les changements dans l'utilisation des terres affectent leur durabilité. L'objectif de cette thèse est de développer une approche multidimensionnelle pour évaluer la dégradation des forêts et les relations avec la dynamique de l'utilisation des terres afin d’estimer leur vulnérabilité. La thèse a été appliquée à Paragominas (Brésil) et Di Linh (Vietnam). À Paragominas, la dégradation est directement liée à l’exploitation sélective du bois et au feu, impliquant des changements dans la structure forestière. Grâce aux outils de télédétection, nous avons cartographié la biomasse forestière aérienne à partir de données de stock de carbone et avons étudié les conséquences de la dégradation sur les structures forestières. Nous avons aussi constaté que 58 % de la dégradation était expliquée par l’analyse des changements d’occupation du sol. La distribution des forêts dégradées est pilotée par la fragmentation issue de l’expansion du soja mais est aussi associée à la déforestation récente et aux pratiques de culture sur brûlis. À Di Linh, la dégradation est due à l'empiètement de la culture de café. L'inventaire des différents types d’occupation du sol, combiné aux images Sentinel-2, a permis de cartographier la couverture du sol actuelle. Nous avons construit des trajectoires de dynamique paysagère afin de caractériser l'expansion de la frontière agricole. Nous avons identifié des trajectoires de dégradation et de fragmentation qui affectent le couvert forestier à différentes intensités. Ensemble, ces indicateurs ont mis en évidence des points chauds de vulnérabilité. Grâce aux approches et aux indicateurs de télédétection développés à l'échelle de la forêt et du paysage, nous avons fourni un diagnostic holistique des forêts dans les paysages modifiés par l'homme. Cette thèse vise à ouvrir la voie à une gestion adaptée et prioritaire des forêts dégradées à l'échelle du paysage.
CORRELATION BETWEEN HORMONAL STATUS OF ESTROGEN RECEPTOR AND MALIGNANCY DEGREE OF INVASIVE DUCTAL BREAST CANCER
Authors: Trisna Windy Ayustyas , Sahudi Sahudi , Kusumastuti Etty Hary 
Published: February 2021

Background: Globocan data in 2018 shows the cancer incidence in Indonesia. The highest case in women is breast cancer. The chance of survival for patients with high malignancy (Grade III) is only 11.86%, while for patients with low malignancy (Grade I) can reach 71.69%. Estrogen exposure is a risk factor for breast cancer. The hormone causes its effect through the estrogen receptor which is a core protein. Patients with positive receptor have 5 and 10 years survival rate which is better than patients with negative estrogen receptor. Objective: To identify the correlation between hormonal status of estrogen receptor and malignancy degree of invasive ductal breast cancer. Material and Method: This research is an observational analytic study. The sample used was patient medical record data in 2015-2017 in Anatomical Pathology Unit, Central Laboratory Installation, Dr. Soetomo General Hospital. Results: The data used was 694 patients medical record in 2015-2017. Approximately 56 patients (86%) had hormonal status of positive estrogen receptor with grade I cancer, 180 patients (70%) were in grade II, and 217 patients (45%) were in grade III. Approximately 9 patients (14%) had hormonal status of negative estrogen receptor with grade I cancer, 71 patients (28%) were in grade II, and 161 patients (34%) were in grade III. The result using Chi-Square test found Chi-Square value in the amount of 27.413 with a significance value of 0.000 (p <0.01). Conclusion: There is a positive correlation between the hormonal status of estrogen receptor and malignancy degree of invasive ductal breast cancer.
Peramalan Indeks Harga Saham Gabungan (IHSG) dengan Metode Extreme Learning Machine (ELM)
Authors: Arifianty Afifah , Mulyono Mulyono , Irzal Med 
Published: February 2021

Abstrak
Indeks Harga Saham Gabungan (IHSG) merupakan suatu nilai untuk mengukur kinerja seluruh saham. IHSG mencerminkan perkembangan pasar secara keseluruhan. Jika IHSG mengalami kenaikan dari hari kemarin maka dapat disimpulkan beberapa saham yang berada pada bursa efek mengalami kenaikan. Oleh karena itu, peramalan harga akan sangat bermanfaat untuk para investor, sehingga mereka dapat mengetahui prospek investasi saham di masa datang. Ada banyak metode untuk peramalan. Tetapi, metode-metode yang telah ada sebelumnya membutuhkan waktu komputasi yang relatif lebih lama. Metode Jaringan Syaraf Tiruan(JST) dikhawatirkan akan semakin ditinggalkan karena diperlukan waktu yang lama dalam pengambilan keputusan. Untuk mengatasi masalah, Huang (2004) menemukan sebuah metode pembelajaran dalam JST bernama Extreme Learning Machine (ELM). ELM merupakan jaringan syaraf tiruan feedforward dengan satu hidden layer atau lebih dikenal dengan istilah Single hidden Layer Feedforward neural Networks(SLFNs) (Sun et al, 2008). Pada metode ini, faktor yang digunakan dalam peramalan hanya faktor data masa lalu, bukan disebabkan faktor lain seperti politik, ekonomi dan lain-lain.
Kata kunci: Indeks Harga Saham Gabungan, Peramalan, Jaringan Syaraf Tiruan, Extreme Learning Machine.