bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of 3 T and 7 T MRI for the Clinical Evaluation of Uveal Melanoma
Authors: Tang Michael C.Y. , Jaarsma‐Coes Myriam G. , Ferreira Teresa A. , Zwirs ‐ Grech Fonk Lorna , Marinkovic Marina , Luyten Gregorius P.M. , Beenakker Jan‐Willem M. 
Published: October 2021

BackgroundMagnetic resonance imaging (MRI) is increasingly being used in the diagnosis and treatment planning of uveal melanoma (UM), the most common primary intraocular tumor. Initially, 7 T MRI was primarily used, but more recently these techniques have been translated to 3 T, as it is more commonly available.PurposeCompare the diagnostic performance of 3 T and 7 T MRI of UM.Study TypeProspective.PopulationTwenty‐seven UM patients (19% female).Field Strength/Sequence3 T: T1‐ and T2‐weighted three‐dimensional (3D) spin echo (SE) and multi‐slice (MS) SE, 7 T: T1‐weighted 3D gradient echo (GE), T2‐weighted 3D SE and MS SE, 3 T and 7 T GE dynamic contrast‐enhanced. T1 weighted images: acquired before and after Gadolinium (Gd) administration.AssessmentFor all sequences, scan and diagnostic quality was quantified using a 5‐point Likert scale. Signal intensities on T1 and T2 relative to choroid and eye muscle respectively were assessed as well as the tumor prominence. Finally, the perfusion time‐intensity curves (TICs) were classified as plateau, progressive, or wash‐out.Statistical TestsImage quality scores were compared between both field strengths using Wilcoxon signed‐rank and McNemar tests. Paired t‐tests and Bland–Altman were used for comparing tumor prominences. P < 0.05 was considered statistically significant.ResultsImage quality was comparable between 3 T and 7 T, for 3DT1, 3DT2, 3DT1Gd (P = 0.86; P = 0.34; P = 0.78, respectively) and measuring tumor dimensions (P = 0.40). 2DT1 and 2DT2 image quality were rated better on 3 T compared to 7 T. Most UM had the same relative signal intensities at 3 T and 7 T on T1 (17/21) and T2 (13/17), and 16/18 diagnostic TICs received the same classification. Tumor prominence measurements were similar between field strengths (95% confidence interval: −0.37 mm to 0.03 mm, P = 0.097).Data ConclusionDiagnostic performance of the evaluated 3 T protocol proved to be as capable as 7 T, with the addition of 3 T being superior in assessing tumor growth into nearby anatomical structures compared to 7 T.Level of Evidence2Technical EfficacyStage 3
Detection of Saint Louis encephalitis virus in two Brazilian states
Authors: Moraes Marília M. , Kubiszeski Janaina Rigotti , Vieira Carla J. da Silva Pessoa , Gusmao Arianne Fagotti , Pratis Taina Silva , Colombo Tatiana E. , Thies Sirlei Franck , do Carmo Araujo Fabiana , Zanelli Cleslei F. , Milhim Bruno Henrique Gonçalves de Aguiar , da Silva Gislaine C. D. , Nogueira Maurício L. , Pacca Carolina C. , Bronzoni Roberta V. de Morais , Mondini Adriano 
Published: October 2021

AbstractWe describe the circulation of Saint Louis encephalitis virus (SLEV) in two Brazilian States during outbreaks of Dengue and Zika viruses. We detected the virus in a patient from Araraquara, State of São Paulo, and in patients and in a mosquito pool of Culex quinquefasciatus from Sinop, State of Mato Grosso. Phylogenetic analysis grouped samples from this study within genotype V, which are closely related to other strains that previously circulated in other parts of the country. Genotype V seems to have established circulation in Brazil.
Bladder preserving robotic pelvic exenteration for locally advanced rectal cancer‐technique and short‐term outcomes
Authors: Jaganmurugan Ramamurthy , Kazi Mufaddal , Sukumar Vivek , Gori Jayesh , Prakash Gagan , Pal Mahendra , Bakshi Ganesh , de Souza Ashwin , Saklani Avanish 
Published: October 2021

AbstractAimIn selected patients with advanced rectal cancers involving the prostate or seminal vesicles, the bladder can be preserved to avoid the complications associated with an ileal conduit. The study was aimed at reviewing the technique and short‐term outcomes of patients that underwent bladder sparing robotic pelvic exenteration with suprapubic cystostomy (SPC).MethodsCase series of bladder preserving exenteration from a single tertiary care center. Technique for en‐bloc prostatectomy with abdominoperineal resection is described.ResultsFive patients underwent bladder sparing robotic pelvic exenteration with SPC, all had R0 resections. Four patients had prostatic invasion and one patient had prostatic adenocarcinoma. Postoperative complications were seen in three patients of which two were re‐explored. At a median follow‐up of 10 months, two patients developed systemic relapses. There were no local recurrences.ConclusionRobotic bladder sparing exenteration is technically feasible, provides acceptable short‐term outcomes, and avoids complications of ileal conduit.
The inadequate use of the determination coefficient in analytical calibrations: How other parameters can assess the goodness‐of‐fit more adequately
Authors: Sanchez Juan M. 
Published: October 2021

AbstractSimple linear regression using ordinary least‐squares is the most common function applied in laboratories for analytical calibrations. The determination and/or the correlation coefficients are usually the parameters applied for assessing the goodness‐of‐fit of a simple linear calibration. However, these parameters are unable to detect the highly biased results at low calibration levels that are obtained with ordinary least‐squares. In this study, the use of other parameters based on the relative standard errors of the calculated contents is evaluated. It has been found that these alternative parameters can detect the biased results obtained at low calibration levels with ordinary least‐squares, being the relative standard error the one that seems to provide the most adequate results. Ordinary least‐squares should only be applied if the lower limit of quantification is set to at least five times above the conventional limit of quantification. For trace analysis, where the lowest possible limit of quantification is required, weighted least‐squares should be applied to obtain accurate estimates, especially at low concentrations. One of the greatest advantages of the relative standard error is that this parameter can be determined for all types of regression functions and is not limited to calibrations with linear relationships between the variables.
Specialized Feeding Patterns and Marine Resource Use by Nonnative Catfishes in a Coastal River Ecosystem Revealed by Dietary and Stable Isotopic Analyses
Authors: Belkoski David J. , Drzewicki Maya , Scharf Frederick S. 
Published: October 2021

Abstract
Two large predatory catfishes, the Flathead Catfish Pylodictis olivaris and Blue Catfish Ictalurus furcatus, have been introduced into multiple U.S. Atlantic slope drainages in recent decades, with concomitant reductions in native fish abundance and changes in faunal community composition. Here, we report on a study of the trophic ecology of sympatric Flathead Catfish and Blue Catfish in the lower Cape Fear River, North Carolina, to estimate trophic positions and identify possible impacts on marine and estuarine prey resources. We applied both dietary and stable isotope analysis to quantify species-specific foraging patterns, as well as the extent of variation among tributaries, seasonal periods, and ontogeny. Both catfish species displayed limited dietary breadth and specialized feeding patterns focused on prey resources within a restricted range of trophic levels. Dietary overlap between Blue Catfish and Flathead Catfish was low, and the species were separated by more than one trophic position. Flathead Catfish relied heavily on fish prey throughout ontogeny, with macroinvertebrates (crustaceans) as a consistent secondary prey resource, and showed increased reliance on potential anadromous prey resources at the largest sizes. Blue Catfish diets were dominated by the invasive Asian clam Corbicula fluminea, with contributions from fish prey only increasing for the largest individuals. Catfish trophic ecology varied among tributaries, and to a greater extent for Flathead Catfish, in terms of both the fish fauna eaten and the relative contribution of different invertebrate prey. Isotopic signatures for Flathead Catfish aligned with stomach contents to indicate a greater contribution of marine prey resources, including anadromous fishes, in the main-stem Cape Fear River compared with the Black and Northeast Cape Fear rivers. Our findings indicate that the predatory impacts of catfishes introduced to coastal river ecosystems will differ considerably between catfish species and may also vary within systems across fine spatial scales.
An anthropomorphic pelvis phantom for MR‐guided prostate interventions
Authors: Bauer Dominik F. , Adlung Anne , Brumer Irène , Golla Alena‐Kathrin , Russ Tom , Oelschlegel Eva , Tollens Fabian , Clausen Sven , Aumüller Philipp , Schad Lothar R. , Nörenberg Dominik , Zöllner Frank G. 
Published: October 2021

PurposeTo design and manufacture a pelvis phantom for magnetic resonance (MR)‐guided prostate interventions, such as MRGB (MR‐guided biopsy) or brachytherapy seed placement.MethodsThe phantom was designed to mimic the human pelvis incorporating bones, bladder, prostate with four lesions, urethra, arteries, veins, and six lymph nodes embedded in ballistic gelatin. A hollow rectum enables transrectal access to the prostate. To demonstrate the feasibility of the phantom for minimal invasive MRI‐guided interventions, a targeted inbore MRGB was performed. The needle probe was rectally inserted and guided using an MRI‐compatible remote controlled manipulator (RCM).ResultsThe presented pelvis phantom has realistic imaging properties for MR imaging (MRI), computed tomography (CT) and ultrasound (US). In the targeted inbore MRGB, a prostate lesion was successfully hit with an accuracy of 3.5 mm. The experiment demonstrates that the limited size of the rectum represents a realistic impairment for needle placements.ConclusionThe phantom provides a valuable platform for evaluating the performance of MRGB systems. Interventionalists can use the phantom to learn how to deal with challenging situations, without risking harm to patients.
Dual demise following laser surgery for twin‐twin transfusion syndrome: Analysis of 52 cases at a single fetal surgery center
Authors: Youssefzadeh Ariane C. , Glassen Gabrielle L. , Chon Andrew H. , Korst Lisa M. , Esakoff Tania F. , Afshar Yalda , Gheorghe Ciprian P. , Llanes Arlyn , Chmait Ramen H. 
Published: October 2021

AbstractObjectiveTo evaluate all individual cases of dual twin demise following laser surgery for twin‐twin transfusion syndrome (TTTS).MethodThis is an analysis of all monochorionic diamniotic twin gestations with TTTS complicated by dual demise following laser surgery from 2006 to 2019. Cases were reviewed by (1) a fetal surgeon researcher and (2) a panel of independent experienced maternal‐fetal medicine specialists to code an etiology of demise for the donor and recipient, and to assess for possible preventability.ResultsOf 753 twins that underwent laser surgery for TTTS, 52 (6.9%) had postoperative dual demise. In this subgroup, gestational age at surgery was 19.5 (16.1–24.9) weeks, and 36 (69.2%) patients were Quintero stage III and IV. The most common etiology was the spectrum of disorders leading to preterm delivery, which included cervical insufficiency, preterm premature rupture of membranes, and preterm labor (44.2% and 48.1%, donor and recipient, respectively). Some degree of preventability was estimated for 23.1% of dual demises.ConclusionsThe most common cause of dual demise post laser surgery for TTTS was preterm birth, reinforcing the need for studies regarding the etiology and prevention of post‐fetoscopy prematurity. Nearly one‐quarter of dual demise cases were deemed potentially preventable.
International use of N = 1 research design with secondary students with disabilities
Authors: Hu Xiaoyi , Wilczynski Susan M. , Ma Yongqiang , Jin Ning 
Published: October 2021

AbstractSchools must accurately implement effective interventions targeting deficits and/or learning challenges for secondary school‐aged students with disabilities to fulfill their responsibility of preparing students for life after high school. School psychologists supporting this mission may be frustrated by the limited research conducted with secondary students. This study is designed to describe the evidence base for interventions used with secondary school students by relying on N = 1 research design studies. N = 1 research design can establish a functional relationship between the independent and dependent variable(s) and allows for the complexity of real world intervention implementation as experienced by practicing school psychologists, making N = 1 an ideal research base on which to make practical decisions in secondary schools. Although interventions increased secondary school‐aged students' performance across studies, not enough well‐designed studies were conducted across research groups for any specific intervention (i.e., meeting the minimum criteria established by What Works Clearinghouse) at the secondary school level. As a result, school psychologists will need to rely heavily on their professional judgment when combining the best available evidence with client and contextual variables to make individualized decisions for secondary school students. An application of this evidence‐based practice decision‐making model for a secondary student is provided.
Protein Data Bank Japan: Celebrating our 20th anniversary during a global pandemic as the Asian hub of three dimensional macromolecular structural data
Authors: Bekker Gert‐Jan , Yokochi Masashi , Suzuki Hirofumi , Ikegawa Yasuyo , Iwata Takeshi , Kudou Takahiro , Yura Kei , Fujiwara Toshimichi , Kawabata Takeshi , Kurisu Genji 
Published: October 2021

AbstractProtein Data Bank Japan (PDBj), a founding member of the worldwide Protein Data Bank (wwPDB) has accepted, processed and distributed experimentally determined biological macromolecular structures for 20 years. During that time, we have continuously made major improvements to our query search interface of PDBj Mine 2, the BMRBj web interface, and EM Navigator for PDB/BMRB/EMDB entries. PDBj also serves PDB‐related secondary database data, original web‐based modeling services such as Homology modeling of complex structure (HOMCOS), visualization services and utility tools, which we have continuously enhanced and expanded throughout the years. In addition, we have recently developed several unique archives, BSM‐Arc for computational structure models, and XRDa for raw X‐ray diffraction images, both of which promote open science in the structural biology community. During the COVID‐19 pandemic, PDBj has also started to provide feature pages for COVID‐19 related entries across all available archives at PDBj from raw experimental data and PDB structural data to computationally predicted models, while also providing COVID‐19 outreach content for high school students and teachers.
Structural and biochemical studies of an iterative ribosomal peptide macrocyclase
Authors: Li Gengnan , Patel Krishna , Zhang Yi , Pugmire Jackson K. , Ding Yousong , Bruner Steven D. 
Published: October 2021

AbstractMicroviridins, tricyclic peptide natural products originally isolated from cyanobacteria, function as inhibitors of diverse serine‐type proteases. Here we report the structure and biochemical characterization of AMdnB, a unique iterative macrocyclase involved in a microviridin biosynthetic pathway from Anabaena sp. PCC 7120. The ATP‐dependent cyclase, along with the homologous AMdnC, introduce up to nine macrocyclizations on three distinct core regions of a precursor peptide, AMdnA. The results presented here provide structural and mechanistic insight into the iterative chemistry of AMdnB. In vitro AMdnB‐catalyzed cyclization reactions demonstrate the synthesis of the two predicted tricyclic products from a multi‐core precursor peptide substrate, consistent with a distributive mode of catalysis. The X‐ray structure of AMdnB shows a structural motif common to ATP‐grasp cyclases involved in RiPPs biosynthesis. Additionally, comparison with the noniterative MdnB allows insight into the structural basis for the iterative chemistry. Overall, the presented results provide insight into the general mechanism of iterative enzymes in ribosomally synthesized and post‐translationally modified peptide biosynthetic pathways.
Autoimmune pulmonary alveolar proteinosis with a history of vaping and vitamin E‐positive bronchoalveolar lavage
Authors: Chua Tzy Harn , Takano Angela , Yao Yi Ju , Chow Sau Yee , Devanand Anantham , Tay Chee Kiang 
Published: October 2021

AbstractPulmonary alveolar proteinosis (PAP) can be due to primary autoimmune and secondary causes, including e‐cigarette, or vaping, product use‐associated lung injury. We present a 33‐year‐old male presenting with PAP and a history of vaping. Serum anti‐granulocyte‐macrophage colony‐stimulating factor antibodies were present. Vitamin E (VE), but not VE acetate, was detected in bronchoalveolar lavage. This is the first report of potential association between vaping and autoimmune PAP.
Anti‐MDA5 antibody‐positive clinically amyopathic dermatomyositis with diffuse alveolar damage diagnosed by transbronchial lung cryobiopsy: A case report
Authors: Ishihara Hiroyuki , Kataoka Kensuke , Takei Reoto , Yamano Yasuhiko , Yokoyama Toshiki , Matsuda Toshiaki , Kimura Tomoki , Fukuoka Junya , Johkoh Takeshi , Kondoh Yasuhiro 
Published: October 2021

AbstractDiffuse alveolar damage (DAD) is known to be a pathological hallmark of acute respiratory distress syndrome or acute interstitial pneumonia, and to have a poor prognosis. We report a case of anti‐melanoma differentiation‐associated gene 5 (MDA5) antibody‐positive clinically amyopathic dermatomyositis (CADM) with rapidly progressive interstitial lung disease (RP‐ILD), in which DAD was confirmed by transbronchial lung cryobiopsy at an early stage without respiratory failure. Although this patient initially did not show respiratory failure, his respiratory condition gradually worsened despite intensive immunosuppression therapy and he died 3 months later. Therefore, the early pathological findings of DAD did not match the clinical picture, which showed no respiratory failure. However, these findings were consistent with the subsequent course and poor outcome. Histological DAD, even in the absence of respiratory failure, may indicate a subsequent poor prognosis and explain the refractory course of RP‐ILD with anti‐MDA5 antibody‐positive CADM.
Encapsulating Fe2O3 Nanotubes into Carbon‐Coated Co9S8 Nanocages Derived from a MOFs‐Directed Strategy for Efficient Oxygen Evolution Reactions and Li‐Ions Storage
Authors: Huang Shoushuang , Jin Zhiqiang , Ding Yanwei , Ning Ping , Chen Qiaochuan , Fu Jie , Zhang Qian , Zhang Jie , Xin Peijun , Jiang Yong , Hu Zhangjun 
Published: October 2021

AbstractThe development of high‐efficiency, robust, and available electrode materials for oxygen evolution reaction (OER) and lithium‐ion batteries (LIBs) is critical for clean and sustainable energy system but remains challenging. Herein, a unique yolk–shell structure of Fe2O3 nanotube@hollow Co9S8 nanocage@C is rationally prepared. In a prearranged sequence, the fabrication of Fe2O3 nanotubes is followed by coating of zeolitic imidazolate framework (ZIF‐67) layer, chemical etching of ZIF‐67 by thioacetamide, and eventual annealing treatment. Benefiting from the hollow structures of Fe2O3 nanotubes and Co9S8 nanocages, the conductivity of carbon coating and the synergy effects between different components, the titled sample possesses abundant accessible active sites, favorable electron transfer rate, and exceptional reaction kinetics in the electrocatalysis. As a result, excellent electrocatalytic activity for alkaline OER is achieved, which delivers a low overpotential of 205 mV at the current density of 10 mA cm−2 along with the Tafel slope of 55 mV dec−1. Moreover, this material exhibits excellent high‐rate capability and excellent cycle life when employed as anode material of LIBs. This work provides a novel approach for the design and the construction of multifunctional electrode materials for energy conversion and storage.
Nanosilver‐Particles Integrated Ni3Sn2S2‐CoS Composite as an Advanced Electrode for High Energy Density Hybrid Cell
Authors: Sekhar S. Chandra , Ramulu Bhimanaboina , Arbaz Shaik Junied , Jin Sung Hun , Oh Hyung Suk , Yu Jae Su 
Published: October 2021

AbstractAn ion‐exchange process is a promising approach to design advanced electrode materials for high‐performance energy storage devices. Herein, a nanostructured Ni3Sn2S2‐CoS (NSS‐CS) composite is fabricated by successive hydrothermal and ion‐exchange processes. Since the incorporation of redox‐rich cobalt element enables the NSS‐CS composite to be more electrochemically active, its impact on the electrochemical performance is therefore extensively studied. Particularly, the NSS‐CS‐0.2 g electrode material delivered a high areal capacity of 830.4 µAh cm−2 at 5 mA cm−2. Additionally, a room‐temperature wet‐chemical approach is employed to anchor nanosilver (nAg)‐particles on the NSS‐CS‐0.2 g (nAg@NSS‐CS‐0.2 g) to further exalt its electrokinetics. Consequently, the nAg@NSS‐CS‐0.2 g electrode shows a higher areal capacity of 948.5 µAh cm−2 (193.5 mAh g−1) than that of the NSS‐CS‐0.2 g. Furthermore, its practicability is also examined by assembling a hybrid cell. The assembled hybrid cell delivers a high areal capacity of 969.2 µAh cm−2 (49.2 mAh g−1) at 7 mA cm−2 and maximum areal energies and power densities of 0.784 mWh cm−2 (40.8 Wh kg−1) and 45 mW cm−2 (2347.4 W kg−1), respectively. The efficiency of the hybrid cells is also tested by harvesting solar energy, followed by energizing electronic components. This work can pave the way for significant attraction in designing advanced electrodes for energy‐related fields.
The topologically twisted index of $$ \mathcal{N} $$ = 4 SU(N) Super-Yang-Mills theory and a black hole Farey tail
Authors: Hong Junho 
Published: October 2021

Abstract
We investigate the large-N asymptotics of the topologically twisted index of $$ \mathcal{N} $$
N
= 4 SU(N) Super-Yang-Mills (SYM) theory on T2 × S2 and provide its holographic interpretation based on the black hole Farey tail [1]. In the field theory side, we use the Bethe-Ansatz (BA) formula, which gives the twisted index of $$ \mathcal{N} $$
N
= 4 SYM theory as a discrete sum over Bethe vacua, to compute the large-N asymptotics of the twisted index. In a dual $$ \mathcal{N} $$
N
= 2 gauged STU model, we construct a family of 5d extremal solutions uplifted from the 3d black hole Farey tail, and compute the regularized on-shell actions. The gravitational partition function given in terms of these regularized on-shell actions is then compared with a canonical partition function derived from the twisted index by the inverse Laplace transform, in the large-N limit. This extends the previous microstate counting of an AdS5 black string by the twisted index and thereby improves holographic understanding of the twisted index.