bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bright Long‐Lived Circularly Polarized Luminescence in Chiral Chromium(III) Complexes
Authors: Jiménez Juan‐Ramón , Poncet Maxime , Míguez‐Lago Sandra , Grass Stéphane , Lacour Jérôme , Besnard Céline , Cuerva Juan M. , Campaña Araceli G. , Piguet Claude 
Published: March 2021

AbstractA series of highly emissive inert and chiral CrIII complexes displaying dual circularly polarized luminescence (CPL) within the NIR region have been prepared and characterized. The helical [Cr(dqpR)2]3+ (dqp=2,6‐di(quinolin‐8‐yl)pyridine; R=OCH3, Br or C≡CH) complexes were synthesized as racemic mixtures and resolved into their respective PP and MM enantiomers by chiral stationary phase HPLC. The corresponding enantiomers show large glum≈0.2 and high quantum yield of up to 17 %, which afford important CPL brightness of up to 170 m−1 cm−1, a key point for applications as chiral luminescent probes. Moreover, the long‐lived CP‐NIR emission provided by these chromophores (ms range) in aqueous solution opens the way toward the quantification of chiral targets in biological systems with time‐gated detection. Thus, such chiral chromophores based on earth abundant and inert 3d metals open new perspectives in the field of CPL and represent an alternative to precious 4d, 5d and to labile 4f metal‐based complexes.
Enhanced wear resistance of ultra‐high molecular weight polyethylene fibers by modified‐graphite oxide
Authors: Wang Hongqiu , Quan Jiayou , Yu Junrong , Zhu Jing , Wang Yan , Hu Zuming 
Published: March 2021

AbstractA simple and feasible method to enhance the wear resistance of ultra‐high molecular weight polyethylene (UHMWPE) fibers was reported. The graphite oxide (GO) prepared using improved Hummer's method was surface modified with hexadecylamine to improve its compatibility with UHMWPE. Combined with well‐dispersion of modified‐GO (m‐GO) in dichloromethane and the fact that the viscosity of UHMWPE suspension can be decreased by dichloromethane, the well dispersed m‐GO/dichloromethane was added into UHMWPE suspension to improve m‐GO dispersion in UHMWPE fibers. Finally, UHMWPE fibers with different m‐GO concentration were prepared using gel spinning technology. The effect of m‐GO concentration on the structure and properties of modified UHMWPE fibers were investigated. The results indicated that the melting temperature and crystallinity of m‐GO modified UHMWPE fibers increased with increasing of m‐GO concentration, while the fiber's crystal sizes and orientation increased, thus the tensile strength of m‐GO modified UHMWPE fibers remained almost undamaged. The introduction of m‐GO is beneficial to the formation of smooth transfer film on fiber's surface, which enhanced the self‐lubrication of UHMWPE fibers. Compared with pure UHMWPE fiber, the UHMWPE fiber containing 1.5 wt% m‐GO had enhanced wear resistance by 55.4% and still maintained high tensile strength of 29.98 cN dtex−1.
Effects of hetero‐armed star‐shaped PCL‐PLA polymers with POSS core on thermal, mechanical, and morphological properties of PLA
Authors: Doganci Merve Dandan , Caner Derya , Doganci Erdinc , Ozkoc Guralp 
Published: March 2021

AbstractIn this study, AB type‐heteroarm star‐shaped poly(ε‐caprolactone)‐poly(lactic acid) (PCL‐PLA) polymers with polyhedral oligomeric silsesquioxane (POSS) core ((PCL)4‐POSS‐(PLA)4, coded as SPLA) were synthesized successfully by using ring opening polymerization and click chemistry techniques together. The synthesized polymers were compounded with commercial PLA at different blending ratios (PLA/SPLA = 100/0, 95/5, 90/10, and 80/20% wt). The effects of heteroarm SPLA polymers having different arm lengths (n = 10, 20, 30, and 50) on morphological, mechanical, and thermal behaviors of PLA were investigated. It is determined that SPLA polymers with four PLA and four PCL arms on its structure enhanced mechanical properties of PLA. The tensile modulus decreased, and lowest modulus values were observed with blends prepared at 80/20 ratio. Elongation at break values increased in all blends, maximum increment was observed with 1,4‐phenylene diisocyanate (PDI) containing SPLA20 blends prepared at 90/10 ratio. This result showed that SPLA20 had optimum chain length for chain extension reactions of between PLA chains. Besides, a trade compatibilizer PDI was utilized to enhance the intercompatibility of binary polymer blends.
Application of organosilane coatings for improved anti‐adhesive properties enabling facilitated demolding in polymer processing
Authors: Bandl Christine , Krempl Nina , Berger‐Weber Gerald , Kern Wolfgang , Friesenbichler Walter 
Published: March 2021

AbstractEasy and residue‐free demolding is an everlasting topic in the plastics processing industry. Typically, facile ejection of the produced parts from the mold is provided by separation agents (silicon sprays, surface coatings). In this work, a perfluoroalkyl‐based organosilane coating is applied to exchangeable substrates of an injection mold. Besides the simple application, the coating can also be restored easily in a procedure based on flame treatment. Coating and recoating are proven by contact angle measurements with water, while the anti‐adhesive effect and the related relief during demolding are evaluated using a special measuring device in an instrumented two‐plate injection mold. The results reveal that the organosilane layer reduces the demolding forces and the resulting static friction coefficient by 50%. Furthermore, multiple recoating significantly improves the durability of the anti‐adhesive coating. Based on these findings, the easily applicable and renewable organosilane coating represents a suitable alternative to conventional release coatings.
Butterfly‐like Shape Liquid Crystals Based Fused‐Thiophene as Unidimensional Ambipolar Organic Semiconductors with High Mobility
Authors: Ma Tao , Zhong Yu‐Jie , Wang Hai‐Feng , Zhao Ke‐Qing , Wang Bi‐Qin , Hu Ping , Monobe Hirosato , Donnio Bertrand 
Published: March 2021

AbstractMesomorphous butterfly‐like shape molecules based on benzodithiophene, benzodithiophene‐4,8‐dione and cyclopentadithiophen‐4‐one core moieties were efficiently synthesized by the Suzuki‐Miyaura coupling and Scholl oxidative cyclo‐dehydrogenation reactions’ tandem. Most of the butterfly molecules spontaneously self‐organize into columnar hexagonal mesophase. The electron‐deficient systems possess strong solvent‐gelling ability but are not luminescent, whereas the electron‐rich terms do not form gels but strongly emit light between 400 and 600 nm. The charge carrier mobility was also measured by time‐of‐flight transient photocurrent technique in the mesophases for some of the compounds. They display hole‐transport performances with positive charge mobility in the 10−3 cm−2 V−1 s−1 range, consistent with the high degree of ordering and stability of the columnar superstructures. In particular, the mesogen with a benzodithiophen‐4,8‐dione core shows ambipolar charge carrier transport with both high electron (μe=6.6×10−3 cm−2 V−1 s−1) and hole (μh=4.5×10−3 cm−2 V−1 s−1) mobility values.
Investigating automatic emotion processing in boys with autism via eye tracking and facial mimicry recordings
Authors: Van der Donck Stephanie , Vettori Sofie , Dzhelyova Milena , Mahdi Soha Sadat , Claes Peter , Steyaert Jean , Boets Bart 
Published: March 2021

AbstractDifficulties in automatic emotion processing in individuals with autism spectrum disorder (ASD) might remain concealed in behavioral studies due to compensatory strategies. To gain more insight in the mechanisms underlying facial emotion recognition, we recorded eye tracking and facial mimicry data of 20 school‐aged boys with ASD and 20 matched typically developing controls while performing an explicit emotion recognition task. Proportional looking times to specific face regions (eyes, nose, and mouth) and face exploration dynamics were analyzed. In addition, facial mimicry was assessed. Boys with ASD and controls were equally capable to recognize expressions and did not differ in proportional looking times, and number and duration of fixations. Yet, specific facial expressions elicited particular gaze patterns, especially within the control group. Both groups showed similar face scanning dynamics, although boys with ASD demonstrated smaller saccadic amplitudes. Regarding the facial mimicry, we found no emotion specific facial responses and no group differences in the responses to the displayed facial expressions. Our results indicate that boys with and without ASD employ similar eye gaze strategies to recognize facial expressions. Smaller saccadic amplitudes in boys with ASD might indicate a less exploratory face processing strategy. Yet, this slightly more persistent visual scanning behavior in boys with ASD does not imply less efficient emotion information processing, given the similar behavioral performance. Results on the facial mimicry data indicate similar facial responses to emotional faces in boys with and without ASD.Lay SummaryWe investigated (i) whether boys with and without autism apply different face exploration strategies when recognizing facial expressions and (ii) whether they mimic the displayed facial expression to a similar extent. We found that boys with and without ASD recognize facial expressions equally well, and that both groups show similar facial reactions to the displayed facial emotions. Yet, boys with ASD visually explored the faces slightly less than the boys without ASD.
Assessing the validity of administrative health data for the identification of children and youth with autism spectrum disorder in Ontario
Authors: Brooks Jennifer D. , Arneja Jasleen , Fu Longdi , Saxena Farah E. , Tu Karen , Pinzaru Virgiliu Bogdan , Anagnostou Evdokia , Nylen Kirk , Saunders Natasha R. , Lu Hong , McLaughlin John , Bronskill Susan E. 
Published: March 2021

AbstractPopulation‐level identification of children and youth with ASD is essential for surveillance and planning for required services. The objective of this study was to develop and validate an algorithm for the identification of children and youth with ASD using administrative health data. In this retrospective validation study, we linked an electronic medical record (EMR)‐based reference standard, consisting 10,000 individuals aged 1–24 years, including 112 confirmed ASD cases to Ontario administrative health data, for the testing of multiple case‐finding algorithms. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and corresponding 95% confidence intervals (CI) were calculated for each algorithm. The optimal algorithm was validated in three external cohorts representing family practice, education, and specialized clinical settings. The optimal algorithm included an ASD diagnostic code for a single hospital discharge or emergency department visit or outpatient surgery, or three ASD physician billing codes in 3 years. This algorithm's sensitivity was 50.0% (95%CI 40.7–88.7%), specificity 99.6% (99.4–99.7), PPV 56.6% (46.8–66.3), and NPV 99.4% (99.3–99.6). The results of this study illustrate limitations and need for cautious interpretation when using administrative health data alone for the identification of children and youth with ASD.Lay SummaryWe tested algorithms (set of rules) to identify young people with ASD using routinely collected administrative health data. Even the best algorithm misses more than half of those in Ontario with ASD. To understand this better, we tested how well the algorithm worked in different settings (family practice, education, and specialized clinics). The identification of individuals with ASD at a population level is essential for planning for support services and the allocation of resources. Autism Res 2021, 14: 1037–1045. © 2021 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals LLC.
Recent Progress in Electrolyte Development and Design Strategies for Next‐Generation Potassium‐Ion Batteries
Authors: Verma Rakesh , Didwal Pravin N. , Hwang Jang‐Yeon , Park Chan‐Jin 
Published: March 2021

AbstractRechargeable lithium‐ion batteries (LIBs) have attained tremendous success and are extensively used in a wide range of fields. However, due to the scarcity and uneven geographical distribution of Li resources, its price is steadily increasing, which may limit its sustainable application in the near future. Potassium‐ion batteries (PIBs) are promising alternatives to LIBs owing to the earth abundance, low cost, and eco‐friendliness of potassium, and high energy density of PIBs. Although the field of PIBs has seen significant progress in the recent years, some challenges remain that limit their application, such as the severe side reactions between the electrolyte and electrodes, which result in an unstable solid electrolyte interphase, and thus, a low coulombic efficiency. Hence, designing suitable electrolytes is necessary for the development of PIBs. This review summarises the current developments in PIB electrolytes and comprehensively discusses electrolyte design strategies for four major classes of electrolytes, namely non‐aqueous, aqueous, ionic liquid, and solid‐state electrolytes. In addition, the effects of the properties of each class of electrolyte are discussed in detail. Furthermore, ionic liquid electrolytes, an emerging class of electrolytes, are discussed in detail with respect to PIBs. Finally, several critical issues, challenges, and prospects of PIB electrolytes are discussed, and an outlook for the future research direction of PIBs is presented.
Evaluating cell viability heterogeneity based on information fusion of multiple adhesion strengths
Authors: Wei Mingji , Zhang Rongbiao , Zhang Fei , Zhang Yecheng 
Published: March 2021

AbstractCell viability evaluation is significantly meaningful for cellular assays. Some cells with weak viability are easily killed in the detection of anticancer drugs, while others with strong viability survive and proliferate, ultimately leading to the treatment failure or the inaccuracy of biological assays. Accurately evaluating cell viability heterogeneity still remains difficult. This article proposed a multiphysical property information fusion method for evaluating cell viability heterogeneity based on polynomial regression in a single‐channel integrated microfluidic chip. In this method, adhesion strengths τN, that are defined as the magnitude of shear stress needed to detach (100 − N) % of cell population, were extracted as the independent variables of polynomial regression model by calculating the nonlinear fitting of the impedance–response curves for shear stress (cell detachment assay). Besides, by calculating the nonlinear fitting of the drug dose–response curves for cancer cells (IC50 assay), the half‐maximal inhibitory concentration (IC50) was extracted as the dependent variables of polynomial regression model. The results show that the mean relative error of our fusion method averagely reduces by 6.04% and 62.79% compared with the multiple linear regression method and the cell counting method. Moreover, a simplified theoretical model used to describe the quantitative relationship between cell viability and its adhesion strengths was built to provide a theoretical basis for our fusion method.
Study on the neuroprotective effects of Genistein on Alzheimer’s disease
Authors: Duan Xiaoying , Li Yanshuang , Xu Fei , Ding Hong 
Published: March 2021

AbstractAlong with the aging of the world population, the incidence rate of Alzheimer's disease (AD) has been increasing. At present, AD has become one of the most serious problems faced by modern medicine. Studies have shown that estrogen has a positive effect on AD, but estrogen has the side effect of leading to tumors. Recent in vivo studies have shown that genistein, one of the selective estrogen receptor modulators (SERMs), can improve brain function through the blood–brain barrier (BBB), antagonize the toxicity of amyloid β‐protein (Aβ), that is, to inhibit neurotoxicity due to aggregation of beta amyloid protein, and have neuroprotective effects. In addition, the use of Gen can avoid the risk of endometrial cancer and breast cancer caused by estrogen therapy while exerting an estrogen‐like effect, which has some potential for the delay and treatment of AD.
Metastatic renal cell carcinoma complicated by right atrial thrombus
Authors: Jeelani Hafiz Muhammad Abrar , Sheikh Muhammad Mubbashir , Riaz Adeel , Jain Nikita , Tahir Nayha , Ehsan Hamid , Vemireddy Lalitha 
Published: March 2021

AbstractMetastasis of renal cell carcinoma to the heart is a rare event. Herein we present a case of renal cell carcinoma presenting with progressive fatigue, abdominal pain, and weight loss. Imaging studies revealed complex renal mass with extension to right atrium and histopathology confirmed the metastatic renal cell carcinoma.
Biorefining of Pinus pinaster Stump Wood for Ethanol Production and Lignin Recovery
Authors: V. T. Mendes Cátia , Moreira Rui , Portugal António , Graça V. S. Carvalho Maria 
Published: March 2021

AbstractStump wood is a forest residue having significant valorization potential. The aims of this work were to exploit pine stumps as a carbohydrate and lignin feedstock, and to convert the carbohydrate fraction to bioethanol by simultaneous saccharification and fermentation (SSF). Pinus pinaster stump wood (PPSW) was delignified by the alkaline organosolv (AOS) process. Soda (SA) cooking was used as benchmark process. Higher pulp yields were obtained in AOS treatments, whilst SA pulp showed the highest cellulose content. In the SSF of PPSW pulps, high ethanol concentrations were obtained with high productivity and yield. AOS lignins were purer and had lower molar mass and dispersity index, which are important parameters in high‐value co‐product applications.
Efficient Production of Specialized Polymers with Highly Flexible Small‐Scale Plants
Authors: Bruns Bastian , Becker Tristan , Riese Julia , Lier Stefan , Werners Brigitte 
Published: March 2021

AbstractShortened product life cycles and increased demand for specialized products lead to more challenges in efficiently satisfying customer needs. Customer demands are increasingly uncertain in terms of type, location, and volume. As a result, more flexible chemical production plants are required. Modular small‐scale plants can be installed in transportation containers and, therefore, offer the flexibility of easy relocation, enabling production close to the customer or supplier. In a mathematical optimization model, the economic benefit of small‐scale plants in the specialty chemicals market of polymer production is analyzed. Different scenarios created from the real data of a chemical company show that the use of small‐scale plants may lead to a significant reduction in total costs that is mainly due to the transportation costs of raw materials and products.
Cost‐effectiveness analysis of delgocitinib in adult patients with atopic dermatitis in Japan
Authors: Takenaka Motoi , Matsumoto Mai , Murota Hiroyuki , Inoue Sachie , Shibahara Hidetoshi , Yoshida Kazufumi , Takigawa Sotaro , Ishimoto Atsushi 
Published: March 2021

AbstractObjectivesThis study evaluated the cost‐effectiveness of delgocitinib relative to moisturization therapy in adult patients with moderate to severe atopic dermatitis.MethodsThe analysis was performed by using the simulation model with the patient‐level data from a phase 3 study and its longterm extension study (QBA4‐1 Study). The analysis was conducted from the Japanese public healthcare payer's perspective and included only direct medical costs. Health outcomes were evaluated by quality‐adjusted life years. The time horizon of the analysis was one year and no discount rate was applied. In this analysis model, health states were divided into four according to the Investigator's Global Assessment score. The cost‐effectiveness was determined by the incremental cost‐effectiveness ratio using the willingness‐to‐pay threshold of 5 million JPY/quality‐adjusted life years. A probabilistic sensitivity analysis was conducted to evaluate the uncertainty of each parameter used for the analysis.ResultsTotal cost and quality‐adjusted life years gained were 358,810 JPY and 0.867 quality‐adjusted life years for delgocitinib, and 85,890 JPY and 0.798 quality‐adjusted life years for moisturization therapy, respectively. The incremental cost‐effectiveness ratio of delgocitinib relative to moisturization therapy was estimated to be 3.92 million JPY/quality‐adjusted life years. The probability of incremental cost‐effectiveness ratio of delgocitinib vs moisturization therapy being below 5 million JPY/quality adjusted life years was 79.1%.ConclusionsDelgocitinib was rated as a cost‐effective treatment relative to moisturization therapy in adults with moderate to severe atopic dermatitis. Data comparing the drug for reducing inflammation is required.
Contemporary economic burden in a real‐world heart failure population with Commercial and Medicare supplemental plans
Authors: Lam Carolyn S. P. , Wood Robert , Vaduganathan Muthiah , Bueno Hector , Chin Alex , Luporini Saraiva Gabriela , Sörstadius Elisabeth , Tritton Theo , Thomas Joseph , Qin Lei 
Published: March 2021

AbstractBackgroundLimited real‐world data exist on healthcare resource utilization (HCRU) and associated costs of patients with heart failure (HF) with reduced ejection fraction (HFrEF) and preserved EF (HFpEF), including urgent HF visits, which are assumed to be less burdensome than HF hospitalizations (hHFs)HypothesisThis study aimed to quantify the economic burden of HFrEF and HFpEF, via a retrospective, longitudinal cohort study, using IBM® linked claims/electronic health records (Commercial and Medicare Supplemental data only).MethodsAdult patients, indexed on HF diagnosis (ICD‐10‐CM: I50.x) from July 2012 through June 2018, with 6‐month minimum baseline period and varying follow‐up, were classified as HFrEF (I50.2x) or HFpEF (I50.3x) according to last‐observed EF‐specific diagnosis. HCRU/costs were assessed during follow‐up.ResultsAbout 109 721 HF patients (22% HFrEF, 31% HFpEF, 47% unclassified EF; median 18 months' follow‐up) were identified. There were 3.2 all‐cause outpatient visits per patient‐month (HFrEF, 3.3; HFpEF, 3.6); 69% of patients required inpatient stays (HFrEF, 80%; HFpEF, 78%). Overall, 11% of patients experienced hHFs (HFrEF, 23%; HFpEF, 16%), 9% experienced urgent HF visits (HFrEF, 15%; HFpEF, 12%); 26% were hospitalized less than 30 days after first urgent HF visit versus 11% after first hHF. Mean monthly total direct healthcare cost per patient was $9290 (HFrEF, $11 053; HFpEF, $7482).ConclusionsHF‐related HCRU is substantial among contemporary real‐world HF patients in US Commercial or Medicare supplemental health plans. Patients managed in urgent HF settings were over twice as likely to be hospitalized within 30 days versus those initially hospitalized, suggesting urgent HF visits are important clinical events and quality improvement targets.