bluuebunny/crossref_metadata_2025_split huggingface dataset:
Camera-based localization microscopy optimized with calibrated structured illumination
Authors: Schmidt Martin , Hundahl Adam C. , Flyvbjerg Henrik , Marie Rodolphe , Mortensen Kim I. 
Published: March 2021

AbstractUntil very recently, super-resolution localization and tracking of fluorescent particles used camera-based wide-field imaging with uniform illumination. Then it was demonstrated that structured illuminations encode additional localization information in images. The first demonstration of this uses scanning and hence suffers from limited throughput. This limitation was mitigated by fusing camera-based localization with wide-field structured illumination. Current implementations, however, use effectively only half the localization information that they encode in images. Here we demonstrate how all of this information may be exploited by careful calibration of the structured illumination. Our approach achieves maximal resolution for given structured illumination, has a simple data analysis, and applies to any structured illumination in principle. We demonstrate this with an only slightly modified wide-field microscope. Our protocol should boost the emerging field of high-precision localization with structured illumination.
Survey of Audiology Graduate Programs: Training Students in Tinnitus Management
Authors: Henry James A. , Sonstroem Anneka , Smith Brandon , Grush Leslie 
Published: March 2021

Purpose
Although tinnitus is highly prevalent among patients receiving audiology services, the extent to which most audiologists are trained in tinnitus management is not well documented. The extent and type of instruction in tinnitus clinical care provided by audiology graduate (AuD) programs is not clear, nor is it known whether training programs are consistent in their recommendations. It is certainly true that widely accepted standards do not exist to ensure that all tinnitus clinical services are supported by adequate scientific evidence, which may result in unsatisfactory outcomes and unnecessary expense for patients. The purpose of this clinical focus article is to describe the results of an informal survey of AuD programs to determine their level of training for tinnitus management.

Method
A short survey was sent to all 75 American Speech-Language-Hearing Association–accredited AuD programs to assess the extent and type of tinnitus training their students receive.

Conclusions
The 32 AuD programs that responded to our survey provide tinnitus training using a variety of settings and methods. Further research could explore in more detail the extent of training in specific methods provided by these programs, and aim to elicit responses from a greater number of programs and from the students themselves.
Speech Rate Varies With Sentence Length in Typically Developing Children
Authors: Darling-White Meghan , Banks Symone Whitney 
Published: March 2021

Purpose
The primary purpose of this study was to examine the effect of sentence length on speech rate and its characteristics, articulation rate and pauses, in typically developing children.

Method
Sixty-two typically developing children between the ages of 10 and 14 years repeated sentences varying in length from two to seven words. Dependent variables included speech rate (syllables per second), articulation rate (syllables per second), and proportion of time spent pausing.

Results
Speech rate and articulation rate significantly increased with increases in sentence length, but proportion of time spent pausing did not increase with sentence length. There were no significant main effects of age.

Conclusions
This is the first study to suggest that sentence length differentially impacts the component parts of speech rate, articulation rate and pause time. Increases in sentence length led to increases in speech rate, primarily due to increases in articulation rate and not increases in pause time. Articulation rate appears to be highly sensitive to the impact of sentence length, while a higher cognitive–linguistic load may be required to see sentence length effects on pause time.
Potential asteroid discoveries by the ESA Gaia mission
Authors: Carry B. , Thuillot W. , Spoto F. , David P. , Berthier J. , Tanga P. , Mignard F. , Bouquillon S. , Mendez R. A. , Rivet J.-P. , Le Van Suu A. , Dell’Oro A. , Fedorets G. , Frezouls B. , Granvik M. , Guiraud J. , Muinonen K. , Panem C. , Pauwels T. , Roux W. , Walmsley G. , Petit J.-M. , Abe L. , Ayvazian V. , Baillié K. , Baransky A. , Bendjoya P. , Dennefeld M. , Desmars J. , Eggl S. , Godunova V. , Hestroffer D. , Inasaridze R. , Kashuba V. , Krugly Y. N. , Molotov I. E. , Robert V. , Simon A. , Sokolov I. , Souami D. , Tarady V. , Taris F. , Troianskyi V. , Vasylenko V. , Vernet D. 
Published: March 2021

Context. Since July 2014, the Gaia mission of the European Space Agency has been surveying the entire sky down to magnitude 20.7 in the visible. In addition to the millions of daily observations of stars, thousands of Solar System objects (SSOs) are observed. By comparing their positions, as measured by Gaia, to those of known objects, a daily processing pipeline filters known objects from potential discoveries. However, owing to Gaia’s specific observing mode, which follows a predetermined scanning law designed for stars as “fixed” objects on the celestial sphere, potential newly discovered moving objects are characterized by very few observations, which are acquired over a limited time. Furthermore, these objects cannot be specifically targeted by Gaia itself after their first detection. This aspect was recognized early on in the design of the Gaia data processing.
Aims. A daily processing pipeline dedicated to these candidate discoveries was set up to release calls for observations to a network of ground-based telescopes. Their aim is to acquire follow-up astrometry and to characterize these objects.
Methods. From the astrometry measured by Gaia, preliminary orbital solutions are determined, allowing us to predict the position of these potentially newly discovered objects in the sky while accounting for the large parallax between Gaia and the Earth (separated by 0.01 au). A specific task within the Gaia Data Processing and Analysis Consortium has been responsible for the distribution of requests for follow-up observations of potential Gaia SSO discoveries. Since late 2016, these calls for observations (nicknamed “alerts”) have been published via a Web interface with a quasi-daily frequency, together with observing guides, which is freely available to anyone worldwide.
Results. Between November 2016 and the end of the first year of the extended mission (July 2020), over 1700 alerts were published, leading to the successful recovery of more than 200 objects. Among them, six have a provisional designation assigned with the Gaia observations; the others were previously known objects with poorly characterized orbits, precluding identification at the time of Gaia observations. There is a clear trend for objects with a high inclination to be unidentified, revealing a clear bias in the current census of SSOs against high-inclination populations.
Zur Rolle des sozioökonomischen Status bei der Inanspruchnahme fachspezifischer Versorgung von psychisch auffälligen Kindern und Jugendlichen in Deutschland: Ergebnisse der BELLA-Studie
Authors: Reiß Franziska , Schlack Robert , Otto Christiane , Meyrose Ann-Katrin , Ravens-Sieberer Ulrike 
Published: March 2021

ZusammenfassungZiel der Studie Kinder und Jugendliche mit einem niedrigen sozioökonomischen Status (SES) sind signifikant häufiger von psychischen Auffälligkeiten betroffen als Gleichaltrige mit einem hohen SES. Unklar bleibt die Bedeutung des familiären SES in Hinblick auf die Inanspruchnahme fachärztlicher Versorgung. Die vorliegende Studie untersucht die Inanspruchnahme psychiatrisch-psychotherapeutischer Versorgung bei Kindern und Jugendlichen mit psychischen Auffälligkeiten in Abhängigkeit von deren SES. Berücksichtigt werden sowohl Symptome psychischer Störungen als auch die damit einhergehende Beeinträchtigung.Methodik Datengrundlage ist die bevölkerungsbezogene BELLA-Studie mit dem Themenschwerpunkt psychische Gesundheit, eine bundesweit repräsentative Unterstichprobe der Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland (KiGGS). Von 2014 bis 2017 wurden 1580 Teilnehmende im Alter von 7 bis 17 Jahren befragt. Der SES umfasst die Indikatoren Haushaltseinkommen, elterliche Bildung und berufliche Stellung der Eltern. Psychische Auffälligkeiten und Beeinträchtigungen wurden mittels des Strengths and Difficulties Questionnaires (SDQ und SDQ-Impact) erhoben. Die Inanspruchnahme fachspezifischer Versorgung umfasst die Behandlung durch Kinder- und Jugendpsychiater, ärztliche und psychologische Psychotherapeuten sowie Psychologen (PPT-Versorgung). Ein hierarchisches binär-logistisches Regressionsmodell wurde zur Vorhersage der Inanspruchnahme berechnet. Ein weiteres Modell diente der Untersuchung von Effekten der SES-Indikatoren auf die Assoziation zwischen psychischen Symptomen und Beeinträchtigungen und der Inanspruchnahme von PPT-Versorgung bei Kindern und Jugendlichen (Moderatoranalysen).Ergebnisse Kinder und Jugendlichen aus Familien mit einem niedrigen SES nehmen häufiger PPT-Versorgung in Anspruch als Gleichaltrige aus Familien mit einem hohen SES. Die Inanspruchnahme von PPT-Versorgung steigt signifikant mit dem Vorliegen von Symptomen psychischer Auffälligkeiten bei Kindern und Jugendlichen (OR=1,15, p≤0,001) sowie mit der Beeinträchtigung aufgrund psychischer Probleme (OR=1,68, p≤0,001). Moderatoreneffekte für das Haushaltseinkommen, die Bildung oder die berufliche Stellung der Eltern wurden nicht entdeckt.Schlussfolgerung Die Inanspruchnahme von PPT-Versorgung hängt signifikant mit der Symptomlast und den Beeinträchtigungen aufgrund psychischer Auffälligkeiten zusammen, nicht jedoch von dem Einkommen, der Bildung und der beruflichen Stellung der Eltern.
Kognition bei Down-Syndrom: Entwicklung über die Lebensspanne und neuropsychologische Diagnostik im Erwachsenenalter
Authors: Loosli Sandra V. , Schmidt Luisa , Nübling Georg , Wlasich Elisabeth , Prix Catharina , Danek Adrian , Levin Johannes 
Published: March 2021

ZusammenfassungDas Down-Syndrom ist die häufigste genetische Ursache einer Intelligenzminderung. Da Menschen mit einem Down-Syndrom ein erhöhtes Risiko aufweisen, an einer Alzheimer-Demenz zu erkranken, ist eine umfassende Untersuchung der kognitiven Funktionen indiziert, sowohl im jungen Erwachsenenalter (zur Erhebung des kognitiven Ausgangsniveaus) als auch im Verlauf zur Demenzdiagnostik. Das weite Spektrum an kognitiver Leistungsfähigkeit bei Menschen mit einem Down-Syndrom stellt eine diagnostische Herausforderung dar. Wir möchten daher einen Überblick geben (1) über die kognitive Entwicklung über die Lebensspanne, (2) über verschiedene mögliche Ursachen kognitiver Veränderungen bei erwachsenen Menschen mit einem Down-Syndrom und (3) über neuropsychologische Diagnostik und entsprechende Verfahren für den Erwachsenenbereich. Schließlich geben wir, auf der Grundlage unserer Erfahrungen, (4) allgemeine Empfehlungen zur Untersuchung und Befundinterpretation bei Menschen mit Intelligenzminderung.
Die Substitutionstherapie Opioidabhängiger in Deutschland: Auswirkungen der 3. BtMVVÄndV aus der Sicht substituierender Ärztinnen und Ärzte
Authors: Lehmann Kirsten , Kuhn Silke , Schulte Bernd , Meyer-Thompson Hans-Günter , Verthein Uwe 
Published: March 2021

Zusammenfassung
Ziel der Studie Die weltweit effektivste Behandlungsform der Opioidabhängigkeit ist die Substitutionsbehandlung mit Opioiden (Opioidsubstitutionstherapie – OST). Diese Therapieform ist auch in Deutschland etabliert. Jedoch bestehen Versorgungslücken, v. a. in ländlichen Gebieten und einzelnen Bundesländern, was auf eine abnehmende Anzahl substituierender ÄrztInnen zurückzuführen ist. Mit der 3. Verordnung zur Änderung der Betäubungsmittel-Verschreibungsverordnung (3. BtMVVÄndV) in 2017 wurden ärztlich-therapeutische Aufgaben der OST in die Richtlinienkompetenz der Bundesärztekammer überführt. Die umfassende Reform der Rahmenbedingungen der OST führt zu einer stärkeren Rechtssicherheit dieser Behandlungsform. Die vorliegende Studie zielt darauf ab, die Auswirkungen der 3. BtMVVÄndV aus der Behandelndenperspektive zu analysieren.
Methode Ein Fragebogen zu individuellen Erfahrungen mit den Veränderungen durch die 3. BtMVVÄndV wurde zwischen August und Dezember 2019 an 2503 substituierende ÄrztInnen in Deutschland sowie an 563 nicht oder länger nicht mehr substituierende ÄrztInnen in Hamburg, Bayern, Nordrhein-Westfalen sowie Sachsen verschickt. Die Versendung erfolgte über die Bundesopiumstelle sowie die Kassenärztlichen Vereinigungen der ausgewählten Bundesländer. Die Auswertung differenziert zwischen substituierenden ÄrztInnen mit und ohne suchtmedizinische Weiterbildung sowie zwischen städtischen und ländlichen Kreisen.
Ergebnisse Die Rücklaufquote substituierender ÄrztInnen lag bei 34,1%. Das Durchschnittsalter betrug 57,9 (± 8,7) Jahre und 64,5% waren männlich. Aus substitutionsärztlicher Sicht waren die relevantesten Änderungen der 3. BtMVVÄndV keine zeitliche Vorgabe für das Erreichen einer Opioidabstinenz (85,3%), die neue Bewertung und Behandlung des Konsums weiterer psychotroper Substanzen (71,0%), die Möglichkeit, die Take-Home-Verordnung auf 30 Tage auszudehnen (70,0%) sowie die größere Rechtssicherheit (66,2%). Die Ausweitung der Konsiliarbehandlung auf 10 PatientInnen erfuhr mit 14,8% wenig Zustimmung. 36,7% sah die Versorgung substituierter PatientInnen weder aktuell noch zukünftig gesichert.
Schlussfolgerung Die Neuerungen durch die 3. BtMVVÄndV wurden positiv aufgenommen und hinsichtlich der erhöhten Rechtssicherheit und therapeutischen Freiheiten als relevant eingestuft. Informationsbedarf besteht in ländlichen Gebieten, bei substituierenden ÄrztInnen ohne suchtmedizinische Weiterbildung sowie bei ÄrztInnen, die in der Vergangenheit substituierten, es aktuell jedoch nicht mehr tun.
Orbital Surgery: Evolution and Revolution
Authors: Newman Steven A. 
Published: March 2021

AbstractThis article traces the development of orbital surgery and its subsequent modifications. It also points out the importance of defining one’s goal before embarking on orbital surgery. Although generally considered part of ophthalmology, surgery on the orbit has been relatively neglected and not routinely practiced. This article reviews the history of development of orbital surgery, both the revolutionary ideas and the evolutionary changes. There are multiple orbital lesions that do not need to be treated with surgery at all. These days chemotherapy, radation therapy, or even immunotherapy may be more appropriate. The most common orbital pathology, that is thyroid orbitopathy, the physician needs to decide whether or not the orbit needs to be decompressed or whether there are problems related to motility that can be dealt with by eye muscle surgery.
The Impact of Prior Abdominal Surgery on Complications of Abdominally Based Autologous Breast Reconstruction: A Systematic Review and Meta-Analysis
Authors: Bond Evalina S. , Soteropulos Carol E. , Yang Qiuyu , Poore Samuel O. 
Published: March 2021

Abstract
Background Approximately half of all patients presenting for autologous breast reconstruction have abdominal scars from prior surgery, the presence of which is considered by some a relative contraindication for abdominally based reconstruction. This meta-analysis examines the impact of prior abdominal surgery on the complication profile of breast reconstruction with abdominally based free tissue transfer.
Methods Literature search was conducted using PubMed, Scopus, and Web of Science. Included studies examined patients with a history of prior abdominal surgery who then underwent abdominally based free flap breast reconstruction. Prior liposuction patients and those with atypical flap designs were excluded. The Newcastle-Ottawa Scale was used to assess study quality. Flap complications included total and partial flap loss, fat necrosis, infection, and reoperation. Donor-site complications included delayed wound healing, infection, seroma, hematoma, and abdominal wall morbidity (hernia, bulge, laxity). Relative risk and 95% confidence intervals (CIs) between groups were calculated. Forest plots, I
2 statistic heterogeneity assessments, and publication bias funnel plots were produced. Publication bias was corrected with a trim-and-fill protocol. Overall effects were assessed by fixed-effects and random-effects models.
Results After inclusion and exclusion criteria were applied, 16 articles were included for final review. These included 14 cohort and 2 case–control studies, with 1,656 (46.3%) patients and 2,236 (48.5%) flaps having undergone prior surgery. Meta-analysis showed patients with prior abdominal surgery were significantly more likely to experience donor-site delayed wound healing with a risk ratio of 1.27 (random 95% CI [1.00; 1.61]; I
2= 4) after adjustment for publication bias. No other complications were statistically different between groups.
Conclusion In patients with a history of prior abdominal surgery, abdominally based free tissue transfer is a safe and reliable option. Abdominal scars may slightly increase the risk of delayed donor-site wound healing, which can aid the surgeon in preoperative counseling.
Avoiding Aesthetic Drawbacks and Stigmata in Dorsal Line Preservation Rhinoplasty
Authors: Neves José Carlos , Arancibia-Tagle Diego 
Published: March 2021

AbstractFor over a century, discussion on the management of nasal dorsum has been a struggle between the techniques of resection and preservation. This is because, each technique has its advantages and disadvantages, with the Joseph technique dominating over the past 30 years despite its surgical stigmas. The dorsum preservation techniques offers a good option for the treatment of nasal hump but like resective techniques it has its drawbacks. This may be the reason why preservation techniques withered but are now making a resurgence. The aim of this article is to describe how to avoid the aesthetic drawbacks of this technique depending on the selected approach.
Management of Acute Facial Nerve and Parotid Injuries
Authors: McElwee Tyler J. , Poche John N. , Sowder Justin C. , Hetzler Laura T. 
Published: March 2021

AbstractAcute soft tissue trauma to the head and neck is a common reason for emergency department presentation and should be appropriately evaluated by a facial plastic surgeon. The evaluation of a patient who has suffered facial trauma should always include a comprehensive facial nerve exam and carry a low threshold of suspicion for parotid duct injury when involving the cheek. Injuries to the facial nerve and parotid duct can result in significant long-term functional, cosmetic, and emotional morbidity, particularly when diagnosis is delayed. In the repair of facial nerve transection, neurorrhaphy technique is primarily based on the ability to obtain tension-free anastomosis and outcomes are in large part related to timing of repair. Parotid duct injuries are generally repaired based on the site of ductal injury. In this article, we present a guide to the relevant anatomy of the facial nerve branches and the parotid duct, the important factors guiding treatment decisions alongside their related risks and benefits, as well as the management of complications of facial nerve neurorrhaphy and parotid duct injuries and repair.
Diagnosis and Management of Articular Cartilage and Meniscus Pathology in the Posterior Cruciate Ligament-Injured Knee
Authors: Ewing Michael A. , Stannard James P. , Cook James L. 
Published: March 2021

AbstractPosterior cruciate ligament (PCL) injuries commonly occur in association with participation in sporting or recreational activities or due to a direct trauma. Cartilage and meniscal lesions are prevalent in PCL-injured knees with increasing likelihood and severity based on extent and duration of trauma to the knee. As such, comprehensive diagnostics should be performed to ascertain all related pathology, and patients should be thoroughly educated regarding treatment options, likely sequelae including posttraumatic osteoarthritis, and associated outcomes. Treatments should address the joint as an organ, ensuring stability, alignment, and functional tissue restoration are optimized by the most efficient and effective means possible. Compliance with patient- and procedure-specific postoperative management protocols is critical for optimizing successful outcomes for these complex cases. The objectives of this review article are to highlight the likelihood and importance of osteochondral and meniscal pathology in the PCL-injured knee, and to provide the best current evidence regarding comprehensive evaluation and management for PCL-injured knees with cartilage and/or meniscal comorbidities.
The role of social capital in the institutionalization of regional place marketing activity
Authors: Halme Juha 
Published: March 2021

AbstractThis paper aims to study the outcomes of the regional level place marketing projects, which contribute towards the fruition of long-term place marketing or branding goals. It applies a theoretical framework based on institutional and social capital theories. Hence, it highlights the role of networks, norms of behavior and values, and trust regarding the institutionalization of regional place marketing activity. Two ERDF (European Structural Development Funding)-funded regional place marketing projects carried out in eastern Finland are explored. The empirical material consists of 23 semi-structured interviews of steering group members of the projects and documentary data on the later developments of the place marketing activity in the regions. The findings show that social capital generated during the projects contributed to the institutionalization of place marketing activity by reinforcing the will to do place marketing together, forming information-sharing practices, and expanding and strengthening stakeholder networks. Results indicate that social relations and structures that are formed during the place marketing collaborations can extend the lifespan of regional place marketing activity beyond short-lived projects, while there remains a need to develop this perspective into a measurable variable.
Do conversations end when people want them to?
Authors: Mastroianni Adam M. , Gilbert Daniel T. , Cooney Gus , Wilson Timothy D. 
Published: March 2021

SignificanceSocial connection is essential to physical and psychological well-being, and conversation is the primary means by which it is achieved. And yet, scientists know little about it—about how it starts, how it unfolds, or how it ends. Our studies attempted to remedy this deficit, and their results were surprising: conversations almost never end when anyone wants them to! At a moment in history when billions of people have been forced to curtail their normal social activities and to reimagine this one, a scientific understanding of conversation could hardly be timelier.