bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dispersal and Land Cover Contribute to Pseudorabies Virus Exposure in Invasive Wild Pigs
Authors: Hernández Felipe A. , Carr Amanda N. , Milleson Michael P. , Merrill Hunter R. , Avery Michael L. , Parker Brandon M. , Pylant Cortney L. , Austin James D. , Wisely Samantha M. 
Published: January 2021

AbstractWe investigated the landscape epidemiology of a globally distributed mammal, the wild pig (Sus scrofa), in Florida (U.S.), where it is considered an invasive species and reservoir to pathogens that impact the health of people, domestic animals, and wildlife. Specifically, we tested the hypothesis that two commonly cited factors in disease transmission, connectivity among populations and abundant resources, would increase the likelihood of exposure to both pseudorabies virus (PrV) and Brucella spp. (bacterial agent of brucellosis) in wild pigs across the Kissimmee Valley of Florida. Using DNA from 348 wild pigs and sera from 320 individuals at 24 sites, we employed population genetic techniques to infer individual dispersal, and an Akaike information criterion framework to compare candidate logistic regression models that incorporated both dispersal and land cover composition. Our findings suggested that recent dispersal conferred higher odds of exposure to PrV, but not Brucella spp., among wild pigs throughout the Kissimmee Valley region. Odds of exposure also increased in association with agriculture and open canopy pine, prairie, and scrub habitats, likely because of highly localized resources within those land cover types. Because the effect of open canopy on PrV exposure reversed when agricultural cover was available, we suggest that small-scale resource distribution may be more important than overall resource abundance. Our results underscore the importance of studying and managing disease dynamics through multiple processes and spatial scales, particularly for non-native pathogens that threaten wildlife conservation, economy, and public health.
An Efficient Descent Method for Locally Lipschitz Multiobjective Optimization Problems
Authors: Gebken Bennet , Peitz Sebastian 
Published: January 2021

AbstractWe present an efficient descent method for unconstrained, locally Lipschitz multiobjective optimization problems. The method is realized by combining a theoretical result regarding the computation of descent directions for nonsmooth multiobjective optimization problems with a practical method to approximate the subdifferentials of the objective functions. We show convergence to points which satisfy a necessary condition for Pareto optimality. Using a set of test problems, we compare our method with the multiobjective proximal bundle method by Mäkelä. The results indicate that our method is competitive while being easier to implement. Although the number of objective function evaluations is larger, the overall number of subgradient evaluations is smaller. Our method can be combined with a subdivision algorithm to compute entire Pareto sets of nonsmooth problems. Finally, we demonstrate how our method can be used for solving sparse optimization problems, which are present in many real-life applications.
Psychological risk factors that characterize the trajectories of quality of life after a physical trauma: a longitudinal study using latent class analysis
Authors: Visser Eva , Oudsten Brenda Leontine Den , Gosens Taco , Lodder Paul , De Vries Jolanda 
Published: January 2021

Abstract
Background
The course and corresponding characteristics of quality of life (QOL) domains in trauma population are unclear. Our aim was to identify longitudinal QOL trajectories and determine and predict the sociodemographic, clinical, and psychological characteristics of trajectory membership in physical trauma patients using a biopsychosocial approach.

Methods
Patients completed a questionnaire set after inclusion, and at 3, 6, 9, and 12 months follow-up. Trajectories were identified using repeated-measures latent class analysis. The trajectory characteristics were ranked using Cohen’s d effect size or phi coefficient.

Results
Altogether, 267 patients were included. The mean age was 54.1 (SD = 16.1), 62% were male, and the median injury severity score was 5.0 [2.0—9.0]. Four latent trajectories were found for psychological health and environment, five for physical health and social relationships, and seven trajectories were found for overall QOL and general health. The trajectories seemed to remain stable over time. For each QOL domain, the identified trajectories differed significantly in terms of anxiety, depressive symptoms, acute stress disorder, post-traumatic stress disorder, Neuroticism, trait anxiety, Extraversion, and Conscientiousness.

Discussion
Psychological factors characterized the trajectories during 12 months after trauma. Health care providers can use these findings to identify patients at risk for impaired QOL and offer patient-centered care to improve QOL.
Changes in the concentration of air pollutants before and after the COVID-19 blockade period and their correlation with vegetation coverage
Authors: Zhou Manguo , Huang Yanguo , Li Guilan 
Published: January 2021

AbstractIn order to control the spread of COVID-19, China had implemented strict lockdown measures. The closure of cities had had a huge impact on human production and consumption activities, which had greatly reduced population mobility. This article used air pollutant data from 341 cities in mainland China and divided these cities into seven major regions based on geographic conditions and climatic environment. The impact of urban blockade on air quality during COVID-19 was studied from the perspectives of time, space, and season. In addition, this article used Normalized Difference Vegetation Index (NDVI) to systematically analyze the characteristics of air pollution in the country and used the Pearson correlation coefficient to explore the relationship between NDVI and the air pollutant concentrations during the COVID-19 period. Then, linear regression was used to find the quantitative relationship between NDVI and AQI, and the fitting effect of the model was found to be significant through t test. Finally, some countermeasures were proposed based on the analysis results, and suggestions were provided for improving air quality. This paper has drawn the following conclusions: (1) the concentration of pollutants varied greatly in different regions, and the causes of their pollution sources were also different. The region with the largest decline in AQI was the Northeast China (60.01%), while the AQI in the southwest China had the smallest change range, and its value had increased by 1.72%. In addition, after the implementation of the city blockade, the concentration of NO2 in different regions dropped the most, but the increase in O3 was more obvious. (2) Higher vegetation coverage would have a beneficial impact on the atmospheric environment. Areas with higher NDVI values have relatively low AQI. There is a negative correlation between NDVI and AQI, and an average increase of 0.1 in NDVI will reduce AQI by 3.75 (95% confidence interval). In the case of less human intervention, the higher the vegetation coverage, the lower the local pollutant concentration will be. Therefore, the degree of vegetation coverage would have a direct or indirect impact on air pollution.
Synergistic and concentration-dependent toxicity of multiple heavy metals compared with single heavy metals in Conocarpus lancifolius
Authors: Redha Amina , Al-Hasan Redha , Afzal Mohammad 
Published: January 2021

AbstractWhile heavy metals (HMs) naturally occur in soil, anthropogenic activities can increase the level of these toxic elements. Conocarpus lancifolius Engl. (Combretaceae) was investigated as a potential phytoremediator of soils contaminated with HM containing crude oil. This study assessed the potential of C. lancifolius (CL), a locally available plant species in Kuwait, for resolving local issues of the HM-contaminated soils. The absorption, accumulation, and distribution of three toxic HMs (Cd, Ni, and Pb) and essential metals (Fe, Mg, and metalloid Se) were examined, and their role in plant toxicity and tolerance was evaluated. Conocarpus lancifolius plants were exposed to two different concentrations of single and mixed HMs for 30 days. The accumulation of HMs was determined in the roots, leaves, stems, and the soil using ICP/MS. Biomass, soil pH, proline and protein content, and bioaccumulation, extraction, and translocation factors were measured. The bioaccumulation, extraction, and transcription factors were all >1, indicating CC is a hyperaccumulator of HM. The HM accumulation in CL was concentration-dependent and depended on whether the plants were exposed to individual or mixed HMs. The C.C leaves, stems, and roots showed a significant accumulation of antioxidant constituents, such as proline, protein, Fe, Mg, and Se. There was an insignificant increase in the soil pH, and a decrease in plant biomass and a significant increase in protein, and osmoprotective-proline as a result of the interaction of mixed heavy metals that are more toxic than single heavy metals. This study indicates that C. lancifolius is a good candidate for phytoremediation of multiple HM-contaminated soils. Further studies to establish the phyto-physiological effect of multiple heavy metals are warranted.
Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion
Authors: Szkudelska Katarzyna , Okulicz Monika , Szkudelski Tomasz 
Published: January 2021

AbstractBisphenol A (BPA) is an ubiquitous synthetic chemical exerting numerous adverse effects. Results of rodent studies show that BPA negatively affects adipose tissue. However, the short-term influence of this compound addressing adipocyte metabolism and adipokine secretion is unknown. In the present study, isolated rat adipocytes were exposed for 2 h to 1 and 10 nM BPA. Insulin-induced glucose conversion to lipids along with glucose transport was significantly increased in the presence of BPA. However, basal glucose conversion to lipids, glucose oxidation, and formation of lipids from acetate were unchanged in adipocytes incubated with BPA. It was also shown that BPA significantly increases lipolytic response of adipocytes to epinephrine. However, lipolysis stimulated by dibutyryl-cAMP (a direct activator of protein kinase A) and the antilipolytic action of insulin were not affected by BPA. Moreover, BPA did not influence leptin and adiponectin secretion from adipocytes. Our new results show that BPA is capable of disturbing processes related to lipid accumulation in isolated rat adipocytes. This is associated with the potentiation of insulin and epinephrine action. The effects of BPA appear already after short-term exposure to low doses of this compound. However, BPA fails to change adipokine secretion.
Dexamethasone enhances CD163 expression in porcine IPKM immortalized macrophages
Authors: Takenouchi Takato , Morozumi Takeya , Wada Emi , Suzuki Shunichi , Nishiyama Yasutaka , Sukegawa Shin , Uenishi Hirohide 
Published: January 2021

AbstractIn our previous study, we established a unique porcine macrophage cell line, immortalized porcine kidney-derived macrophages (IPKM). The purpose of the present study was to further elucidate the characteristics of IPKM. CD163 is a scavenger receptor for the hemoglobin-haptoglobin complex and is used as a phenotypic marker of anti-inflammatory M2 macrophages. The expression of CD163 is enhanced by dexamethasone (DEX), a potent steroidal anti-inflammatory drug, in human and rodent macrophages in vitro. Therefore, we investigated the effects of DEX on CD163 expression in porcine IPKM. Treatment with DEX markedly enhanced CD163 expression in the IPKM. In addition, we found that SB203580, a selective inhibitor of p38 mitogen-activated protein kinase (MAPK), blocked the effects of DEX, suggesting that the p38 MAPK signaling pathway is involved in the regulation of the DEX-induced enhancement of CD163 expression. Since CD163 is considered to be a putative receptor for the porcine reproductive and respiratory syndrome virus (PRRSV), the effects of DEX on the infection of IPKM by PRRSV were evaluated. Although the IPKM were susceptible to infection by the Fostera PRRSV vaccine strain, DEX treatment did not affect the propagation of the virus in the IPKM. This suggests that the DEX-induced enhancement of CD163 expression alone is not sufficient to facilitate the infection of IPKM by PRRSV.
Improved differentiable neural architecture search for single image super-resolution
Authors: Weng Yu , Chen Zehua , Zhou Tianbao 
Published: January 2021

AbstractDeep learning has shown prominent superiority over other machine learning algorithms in Single Image Super-Resolution (SISR). In order to reduce the efforts and resources cost on manually designing deep architecture, we use differentiable neural architecture search (DARTS) on SISR. Since neural architecture search was originally used for classification tasks, our experiments show that direct usage of DARTS on super-resolutions tasks will give rise to many skip connections in the search architecture, which results in the poor performance of final architecture. Thus, it is necessary for DARTS to have made some improvements for the application in the field of SISR. According to characteristics of SISR, we remove redundant operations and redesign some operations in the cell to achieve an improved DARTS. Then we use the improved DARTS to search convolution cells as a nonlinear mapping part of super-resolution network. The new super-resolution architecture shows its effectiveness on benchmark datasets and DIV2K dataset.
Sublimation for Enrichment and Identification of Marker Compounds in Fruits
Authors: Gronbach Manuel , Kraußer Laura , Broese Timo , Oppermann Christina , Kragl Udo 
Published: January 2021

AbstractIn this article, we describe the benefits of sublimation for natural product and food chemistry. The direct sublimation of substances from dried plant powders has not received much attention in research in the past, just like the sublimation of substances from dried plant extracts. We used sublimation to study dried sea buckthorn berry powders and dried sea buckthorn berry extracts. The results of the powder sublimations were compared to that of dried chokeberry, wolfberry, and European cornel powder. 52 marker substances of which 27 are specific for sea buckthorn were found in the sea buckthorn powder sublimates using LC/MS. The majority of them are not described in the literature and were obtained by direct sublimation. Accordingly, sublimation can help to identify new plant constituents. Our identification method was validated by the analysis of four commercially available fruit powders. The sea buckthorn powder showed an almost 80% correlation with the determined marker substances, whereas the other fruit powders did not achieve more than 38% correlation. The sublimates of sea buckthorn extracts show additional marker substances compared to the fruit powder sublimate, and we think that both techniques can be used to fight food fraud.
Application of a multi-objective multi traveling salesperson problem with time windows
Authors: Bonz Justus 
Published: January 2021

AbstractThe pilgrimage to Mecca, which is called Hajj, is the largest annual pedestrian crowd management problem in the world. During the Hajj, the pilgrims are accommodated in camps. For safety reasons, exact times and directions are given to the pilgrims who are moving between holy sites. Despite the importance of complying with those schedules, violations can often be conjectured. Directing a small workforce between the camps to monitor the pilgrims’ compliance with the schedule is an important matter, which will be dealt with in this paper. A type of multi-objective multiple traveling salesperson optimization problem with time windows is introduced to generate the tours for the employees monitoring the flow of pilgrims at the campsite. Four objectives are being pursued: As many pilgrims as possible (1), should be visited with a preferably small workforce (2), the tours of the employees should be short (3) and employees should have short waiting times between visits (4). A goal programming, an enumeration, Augmecon2 and an interactive approach are developed. The topic of supported and non-supported efficient solutions is addressed by determining all efficient solutions with the enumeration approach. The suitability of the approaches is analyzed in a computational study, while using an actual data set of the Hajj season in 2015. For this application, the interactive approach has been identified as the most suitable approach to support the generation of an offer for the project.
Application of telemedicine and eHealth technology for clinical services in response to COVID‑19 pandemic
Authors: Bokolo Anthony Jnr. 
Published: January 2021

AbstractTelemedicine and eHealth refer to the use of information and communication technology (ICT) embedded in software programs with highspeed telecommunications systems for delivery, management, and monitoring of healthcare services. Application of telemedicine have become timely while providing great potentials to protect both medical practitioners and patients, as well as limit social mobility of patients contributing to reduce the spread of the virus. This study employs data from the existing literature to describe the application of telemedicine and eHealth as a proactive measure to improve clinical care. Findings from this study present the significance of telemedicine and current applications adopted during the pandemic. More importantly, the findings present practical application of telemedicine and eHealth for clinical services. Also, polices initiated across the world to promote management of COVID-19 are discussed. Respectively, this study suggests that telemedicine and eHealth can be adopted in times of health emergency, as a convenient, safe, scalable, effective, and green method of providing clinical care.
Removal efficiency of phenol by ozonation process with calcium peroxide from aqueous solutions
Authors: Honarmandrad Zhila , Javid Neda , Malakootian Mohammad 
Published: January 2021

AbstractPhenol has been introduced as a priority pollutant by the US Environmental Protection Agency. Advanced oxidation processes (AOPs) are one of the most efficient methods for removal of non-degradable organic pollutants in aqueous solutions. The removal efficiencies of phenol and COD under optimal conditions pH = 3, phenol concentration = 5 mg/L, CaO2 concentration = 0.025 mg/L, temperature 25 °C, 1 g/min ozonation rate and contact time = 90 min in synthetic and real samples (Zarand coal washing factory in Kerman) were obtained 97.8%, 87% and 80%, 65.4%, respectively. The kinetics of phenol decomposition follows from the pseudo-first-order equation. Thermodynamic studies show that phenol decomposition with ozonation and calcium peroxide is an endothermic process. The use of ozonation process with calcium peroxide is an efficient method and can be recommended as a coefficient method for the removal of phenol.
4-Mercaptopyridine Modified Fiber Optic Plasmonic Sensor for Sub-nM Mercury (II) Detection
Authors: Duan Yifan , Zhang Yang , Wang Fang , Sun Yuting , Chen Ming , Jing Zhenguo , Wang Qiao , Lu Mengdi , Peng Wei 
Published: January 2021

AbstractIn this paper, we propose and demonstrate a high-performance mercury ion sensor with sub-nM detection limit, high selectivity, and strong practicability based on the small molecule of the 4-mercaptopyridine (4-MPY) modified tilted fiber Bragg grating surface plasmon resonance (TFBG-SPR) sensing platform. The TFBG-SPR sensor has a rich mode field distribution and a narrow bandwidth, which can detect the microscopic physical and chemical reactions on the sensor surface with high sensitivity without being disturbed by the external temperature. For the environmental compatibility and highly efficient capture of the toxic mercury ion, 4-MPY is modified on the sensor surface forming a stable (4-MPY)-Hg-(4-MPY) structure due to the specific combination between the nitrogen of the pyridine moiety and the Hg2+ via multidentate N-bonding. Moreover, gold nanoparticles (AuNPs) are connected to the sensor surface through the (4-MPY)-Hg-(4-MPY) structure, which could play an important role for signal amplification. Under the optimized conditions, the limit of detection of the sensor for mercury ions detection in the solution is as low as 1.643×10−10 M (0.1643nM), and the detection range is 1×10−9 M − 1×10−5 M. At the same time, the mercury ion spiked detection with tap water shows that the sensor has the good selectivity and reliability in actual water samples. We develop a valuable sensing technology for on-time environmental Hg2+ detection and in-vivo point of care testing in clinic applications.
COVID-19, uncertainty, and moral experiments
Authors: Klenk Michael , Van de Poel Ibo 
Published: January 2021

AbstractPandemics like COVID-19 confront us with decisions about life and death that come with great uncertainty, factual as well as moral. How should policy makers deal with such uncertainty? We suggest that rather than to deliberate until they have found the right course of action, they better do moral experiments that generate relevant experiences to enable more reliable moral evaluations and rational decisions.
Harry Potter and the Osteopathic Medical School: Creating a Harry Potter-Themed Day as a High-Yield Review for Final Exams
Authors: Bryant Victoria 
Published: January 2021

AbstractIncorporating contemporary fiction into educational activities that are interactive and memorable creates a positive learning environment for students. The current article describes how our medical school created a Harry Potter-themed educational event to review didactic material before a final exam. Students were sorted into Hogwarts houses and collected house points in the 8 themed classrooms that reviewed material for the individual disciplines. The event also included a Quidditch tournament and a Yule Ball. The event received positive feedback from students, encouraging the school’s faculty to look for other opportunities to create similar educational experiences during preclinical medical education.
Control of Local Hardness Gradient of Metal Surface by Inclined Surface Treatment Using Ultrasonic Nanocrystal Surface Modification
Authors: Jo Yeong-Kwan , Gil Yeong-Wook , Shim Do-Sik , Pyun Young-Sik , Park Sang-Hu 
Published: January 2021

AbstractWe propose an effective method to control the local hardness and morphology of a metal surface by tilting the incident angle of a horn during ultrasonic nanocrystal surface modification (UNSM). In this study, surface treatment using UNSM was performed on an S45C specimen and a parameter study was conducted for optimization. The process parameters were the feeding rate, static load, striking force, and processing angle (Ф). In particular, the Ф was analyzed by tilting the horn by 0°, 10°, 20°, 30°, 40°, and 45° to understand its effect on surface hardness and changes in the morphology. From fundamental experiments, some important phenomena were observed, such as grain-microstructure changes along the processing and thickness directions. Furthermore, to verify the practical usefulness of this study, a flat and a hemispherical specimen of S45C material were treated using UNSM with various values of Ф. A significant change in hardness (an increase from 2–45%) and a gradual hardness gradient on the tested specimens could be easily realized by the proposed method. Therefore, we believe that the method is effective for controlling the mechanical hardness of a metal surface.