bluuebunny/crossref_metadata_2025_split huggingface dataset:
Educational Inequalities in Labor Market Exit of Older Workers in 15 European Countries
Authors: MÄCKEN JANA , PRÄG PATRICK , HESS MORITZ , ELLWARDT LEA 
Published: April 2021

AbstractThis article examines country differences in the association between education and voluntary or involuntary labor market exit and whether these country differences map onto institutional characteristics of the countries. Work exit is defined as involuntary or voluntary based on the reasons of exit. Four different types of institutional factors, push and pull, aiming for an earlier work exit and need and maintain factors to retain older workers in employment are considered. Using data from 15 European countries from the longitudinal Survey of Health, Aging and Retirement in Europe (SHARE), discrete-time event history models with a categorical outcome are estimated for each country separately. In a second step, we add macro-level indicators and conduct meta-analyses to analyze country differences. Results show that in almost all countries a social gradient in involuntary work exit exists but not in voluntary exit. Lower-educated workers are more likely to involuntarily exit the labor market. Institutional factors, especially those supporting older workers’ retention in employment, are associated with a smaller social gradient in work exit. Our findings suggest that investments in active labor market expenditures, especially in lifelong learning and rehabilitation for lower educated workers, may help to reduce the social gradient in involuntary work exit.
An efficient LiDAR-based localization method for self-driving cars in dynamic environments
Authors: Zhang Yihuan , Wang Liang , Jiang Xuhui , Zeng Yong , Dai Yifan 
Published: April 2021

AbstractReal-time localization is an important mission for self-driving cars and it is difficult to achieve precise pose information in dynamic environments. In this paper, a novel localization method is proposed to estimate the pose of self-driving cars using a 3D-LiDAR sensor. First, the multi-frame curb features and laser intensity features are extracted. Meanwhile, based on the high-precision curb map generated offline, obstacles on road are detected using region segmentation methods and their features are removed. Furthermore, a map-matching method is proposed to match the features to the map, a robust iterative closest point algorithm is utilized to deal with curb features along with a probability search method dealing with intensity features. Finally, two separate Kalman filters are used to fuse the low-cost global positioning systems and map-matching results. Both offline and online experiments are carried out in dynamic environments and the results demonstrate the accuracy and robustness of the proposed method.
Conscientious objection in firms
Authors: Blanc Sandrine 
Published: April 2021

AbstractThis article asks whether firms should exempt employees when they object to elements of their work that go against their conscience. Fairness requires that we follow the rules of an organization we have joined voluntarily only if these rules express mutual advantage. In corporations, I argue that subordination and exemption provides for mutual advantage better than subordination plus right of exit. This is because agents want to protect their conscientious convictions, even in hierarchical organizations geared towards efficient preference satisfaction. Thus exemptions should be granted in unforeseeable circumstances, provided the costs are limited.
A systematic review of the evidence supporting post-operative medication use in congenital heart disease
Authors: Thompson Elizabeth J. , Foote Henry P. , King Caitlin E. , Srinivasan Sabarish , Ciociola Elizabeth C. , Leung Dennis , Rotta Alexandre T. , Hill Kevin D. , Cohen-Wolkowiez Michael , Hornik Christoph P. 
Published: April 2021

AbstractBackground:Targeted drug development efforts in patients with CHD are needed to standardise care, improve outcomes, and limit adverse events in the post-operative period. To identify major gaps in knowledge that can be addressed by drug development efforts and provide a rationale for current clinical practice, this review evaluates the evidence behind the most common medication classes used in the post-operative care of children with CHD undergoing cardiac surgery with cardiopulmonary bypass.Methods:We systematically searched PubMed and EMBASE from 2000 to 2019 using a controlled vocabulary and keywords related to diuretics, vasoactives, sedatives, analgesics, pulmonary vasodilators, coagulation system medications, antiarrhythmics, steroids, and other endocrine drugs. We included studies of drugs given post-operatively to children with CHD undergoing repair or palliation with cardiopulmonary bypass.Results:We identified a total of 127 studies with 51,573 total children across medication classes. Most studies were retrospective cohorts at single centres. There is significant age- and disease-related variability in drug disposition, efficacy, and safety.Conclusion:In this study, we discovered major gaps in knowledge for each medication class and identified areas for future research. Advances in data collection through electronic health records, novel trial methods, and collaboration can aid drug development efforts in standardising care, improving outcomes, and limiting adverse events in the post-operative period.
Independent origins of populations from Dehong State, Yunnan Province, and the multiple introductions and post-introduction admixture sources of mile-a-minute (Mikania micrantha) in China
Authors: Ji Mei , Ze Sangzi , Tang Saichun , Hu Lianrong , Li Junmin 
Published: April 2021

Abstract
Mile-a-minute (Mikania micrantha Kunth) is a tropical American species and has become a worldwide invasive weed. It was first introduced to mainland China in 1983 in Yingjiang City, Dehong State, Yunnan Province. To assess the origins of populations from Dehong State, Yunnan Province, the genetic structure of 427 individuals from 11 M. micrantha populations from Yunnan, Guangxi, Hainan, and Guangdong provinces were analyzed. A total of 28 alleles were detected in 12 nuclear microsatellite loci. Genetic diversity at the population level was relatively high. An analysis of molecular variance showed that most of the variation occurred within populations (82.73%), and only 18.27% occurred among populations. The genetic differentiation coefficient (FST) was 0.183. The estimated gene flow (Nm) from FST was 1.116. The independent origins of four populations collected from Dehong State, Yunnan Province, was determined by the unweighted pair-group method with arithmetic means clustering and STRUCTURE analysis. Three gene clusters and one admixture gene cluster were found. A Mantel test of pairwise Nei’s genetic distances and pairwise geographic distances revealed no evidence for isolation by distance (r = 0.068, P = 0.343). These results suggest that the post-introduction admixture caused by multiple introductions and high gene flow might contribute to the evolutionary adaptation of M. micrantha. These results could provide a scientific basis for the management of invasive M. micrantha.
ICESat‐2 Constraint Analysis and Monitoring System (CAMS)
Authors: Rebold T. W. , Luthcke S. B. , Pennington T. A. , Syed A. , Beall J. L. , Sabaka T. J. 
Published: April 2021

AbstractThe Ice, Cloud and land Elevation Satellite‐2 was launched on 15 September 2018 with mission goals of collecting surface elevation data that can precisely measure ice sheet topography, cloud and aerosol heights, land topography, as well as vegetation height for ecosystems studies. The Constraint Analysis and Monitoring System (CAMS) was implemented as an ICESat‐2 ground system element to perform Mission Planning and Spacecraft Safety Monitoring. Mission Planning requires CAMS to serve as an interface between the Project Science Office, the Instrument Support Facility and the Mission Operation Control Center. By ingesting inputs received from all three groups, the CAMS builds an optimized and deconflicted timeline of science and instrument activities. Based upon the timeline of activities, the CAMS utilizes a sophisticated set of algorithms to model and predict the location and pointing of the spacecraft instrument relative to the Earth and Sun. From the predicted position and pointing, the CAMS provides precise monitoring of instrument health, and performs space asset laser conjunction detection. Furthermore, the CAMS determines alternative plans to prevent detected health constraint violations or mitigate potential laser conjunctions. This paper provides an overview of the CAMS and presents the operational performance of planning science and instrument activities, the monitoring of instrument constraints for health and safety, and the space asset laser conjunction screening and mitigation process.
ICESat‐2 Early Mission Synopsis and Observatory Performance
Authors: Magruder Lori , Neumann Thomas , Kurtz Nathan 
Published: April 2021

AbstractThe Advanced Topographic Laser Altimetry System (ATLAS) onboard the NASA Ice, Cloud, and land Elevation Satellite‐2 (ICESat‐2) is the newest Earth observing satellite for global elevation studies. The primary objectives for ICESat‐2 follow the objectives of its predecessor, ICESat and also focus on providing cryospheric measurements to determine ice sheet mass balance, and monitor both sea ice thickness and extent. However, the global observations support secondary science objectives as well such as biomass estimation, inland water elevation, sea state height and aerosol concentrations. Since launch of ICESat‐2, ATLAS has collected more than a trillion measurements. This study provides a mission overview, a description of the operational components that enable the altimeter products for science, on‐orbit observatory performance, and assessment of the spacecraft attitude control systems that enable repeat measurements to within 10 m and pointing control within ±45 m. These metrics should be considered for ground‐based validation campaigns or science investigations.
Sensitivity of Tropical Extreme Precipitation to Surface Warming in Aquaplanet Experiments Using a Global Nonhydrostatic Model
Authors: Uribe Alejandro , Vial Jessica , Mauritsen Thorsten 
Published: April 2021

AbstractIncreases of atmospheric water vapor holding capacity with temperature (7% K−1–8% K−1, CC‐rate) can lead to increasing extreme precipitation (EP). Observations show that tropical EP has increased during the last five decades with a rate higher than in the extratropics. Global climate models (GCM's) diverge in the magnitude of increase in the tropics, and cloud‐resolving models (CRM's) indicate correlations between changes in tropical EP and organization of deep convection. We conducted global‐scale aquaplanet experiments at a wide range of resolutions with explicit and parameterized convection to bridge the gap between GCM's and CRM's. We found increases of tropical EP beyond the CC rate, with similar magnitudes when using explicit convection and parametrized convection at the resolution it is tuned for. Those super‐CC rates are produced due to strengthening updrafts where extreme precipitation occurs, and they do not exhibit relations with changes in convective organization.
Multidecadal Evolution of the Turbidity Maximum Zone in a Macrotidal River Under Climate and Anthropogenic Pressures
Authors: Jalón‐Rojas I. , Dijkstra Y. M. , Schuttelaars H. M. , Brouwer R. L. , Schmidt S. , Sottolichio A. 
Published: April 2021

AbstractClimate and human pressures can influence the evolution of estuarine sediment dynamics concurrently, but the understanding and quantification of their cause–effect relationships are still challenging due to the occurrence of complex hydro‐morpho‐sedimentary feedbacks. The Garonne Tidal River (GTR, upper Gironde Estuary, France) is a clear example of a system stressed by both anthropogenic and climate change, as it has been subject to decreasing river discharges, natural morphological changes, and gravel extraction. To understand the relative effect of each hydrological and geomorphological pressure on the turbidity maximum zone (TMZ), the sediment dynamics in the GTR over the last six decades was evaluated using the width‐averaged idealized iFlow model. Model results show a gradual increase in tidal amplitude and currents over the decades that has led to the upstream shift of the landward sediment‐transport capacity components (external M4 tide, spatial settling lag, and tidal return flow). The upstream displacement of the TMZ between the 1950s and the 2010s was estimated to be at least 19 km, of which about three fourth was induced by geomorphological changes and one fourth by hydrological changes. Concerning the geomorphological changes, the natural evolution of the lower Gironde morphology was the main pressure inducing the displacement of the TMZ in the GTR. Anthropogenic and natural changes in morphology and bed roughness in the GTR itself also contributed to this evolution. The natural geomorphological changes were, in turn, probably promoted by the evolution of sediment dynamics, so this study reveals the closed circle that governs the intensification of the TMZ.
Simulations of the Surf Zone Eddy Field and Cross‐Shore Exchange on a Nonidealized Bathymetry
Authors: O'Dea Annika , Kumar Nirnimesh , Haller Merrick C. 
Published: April 2021

AbstractX‐band radar observations from the 2017 Inner Shelf Dynamics Experiment (ISDE) in central California show multiple persistent and pulsatory rip currents on a relatively straight coastline with alongshore‐varying bathymetry. Although past studies have assessed the characteristics of transient rip currents on alongshore uniform beaches, the relative balance of transient versus steady rip current behavior on nonuniform beaches in realistic wave conditions remains poorly understood. Here, a phase‐resolving Boussinesq‐type wave model (funwaveC) is used to assess the role of alongshore‐varying bathymetry and incident conditions in controlling mean and transient surf zone vorticity and velocity fields and their effect on surf zone exchange. The model simulates wave conditions chosen from the ISDE observations and utilizes both an alongshore‐varying bathymetry estimated from the ISDE radar observations and a uniform bathymetry. Results show that the variable bathymetry significantly increases the alongshore‐ and time‐averaged kinetic energy but that this increase is primarily due to the increase in the standing component resulting from mean circulation patterns, with only small changes in the transient component. A variable bathymetry also increases the spectral energy of surf zone vorticity and time‐averaged vorticity forcing at large spatial scales (>100 m). Wave directional spreading has a large impact on the alongshore‐ and time‐averaged enstrophy and on the spectral energy of surf zone vorticity and vorticity forcing at smaller spatial scales (<100 m). In the presence of a directionally spread wavefield, an alongshore‐varying bathymetry slightly increases the total exchange velocity but has little effect on its transient component.
Christiansen Feature Map From the Lunar Reconnaissance Orbiter Diviner Lunar Radiometer Experiment: Improved Corrections and Derived Mineralogy
Authors: Lucey Paul G. , Greenhagen Benjamin , Donaldson Hanna Kerri , Bowles Neil , Flom Abigail , Paige David A. 
Published: April 2021

AbstractMaps of plagioclase, olivine, and pyroxene at 1 km resolution are derived from a combination of data from the Diviner Lunar Radiometer on the Lunar Reconnaissance Orbiter and the Kaguya Multiband Imager. The Diviner instrument features three infrared bands designed to characterize a spectral feature of lunar soils that is sensitive to the average silica polymerization of the surface called the Christiansen Feature, which is directly sensitive to the presence of plagioclase, the dominant lunar silicate. Existing global mineral maps based on near‐IR data largely infer the presence of plagioclase from the bright mineral’s effect on total reflectance, excepting in rare locations where the surface is nearly pure plagioclase and a weak feature in the plagioclase near‐IR spectrum can be relied upon. By integrating both wavelength regions we produced more robust estimates of the abundance of the three dominant minerals. In the process of this work, we also improved the removal of space weathering effects from Christiansen Feature maps, and showed that silica rich compositional anomalies could be reliably detected by decorrelating Christiansen Feature and FeO maps. New silica‐rich locations are reported as are the global abundances of the three major silicates.
Elastic Properties of the Pyrite‐Type FeOOH‐AlOOH System From First‐Principles Calculations
Authors: Thompson Elizabeth C. , Campbell Andrew J. , Tsuchiya Jun 
Published: April 2021

AbstractThe stability, structure, and elastic properties of pyrite‐type (FeS2 structured) FeO2H were determined using density functional theory‐based computations with an internally consistent Coulombic self‐interaction term (Ueff). The properties of pyrite‐type FeO2H are compared to that of pyrite‐type AlO2H, with which it likely forms a solid solution at high temperature, as well as the respective lower pressure CaCl2‐type polymorphs of both endmembers: ϵ‐FeOOH and δ‐AlOOH. Due to substantial differences in the CaCl2‐type → pyrite‐type structural transition pressures of these endmembers, the stabilities of the (Al,Fe)O2H solid solution polymorphs are anticipated to be compositionally driven at lower mantle pressures. As the geophysical properties of (Al,Fe)OOH are structurally dependant, interpretations regarding the contribution of pyrite‐type FeO2H to seismically observed features must take into account the importance of this broad phase loop. With this in mind, Fe‐rich pyrite‐type (Al,Fe)OOH may coexist with Al‐dominant CaCl2‐type δ‐(Al,Fe)OOH in the deep Earth. Furthermore, pyrite‐type (Al0.5–0.6,Fe0.4–0.5)O2H can reproduce the reduced compressional and shear velocities characteristic of seismically observed ultra low velocity zones in the Earth's lowermost mantle while Al‐dominant but Fe‐bearing CaCl2‐type δ‐(Al,Fe)OOH may contribute to large low shear velocity provinces.
Multiplexed targeting of miRNA-210 in stem cell-derived extracellular vesicles promotes selective regeneration in ischemic hearts
Authors: Song Byeong-Wook , Lee Chang Youn , Kim Ran , Kim Won Jung , Lee Hee Won , Lee Min Young , Kim Jongmin , Jeong Jee-Yeong , Chang Woochul 
Published: April 2021

AbstractExtracellular vesicles (EVs) are cell derivatives containing diverse cellular molecules, have various physiological properties and are also present in stem cells used for regenerative therapy. We selected a “multiplexed target” that demonstrates multiple effects on various cardiovascular cells, while functioning as a cargo of EVs. We screened various microRNAs (miRs) and identified miR-210 as a candidate target for survival and angiogenic function. We confirmed the cellular and biological functions of EV-210 (EVs derived from ASCmiR-210) secreted from adipose-derived stem cells (ASCs) transfected with miR-210 (ASCmiR-210). Under hypoxic conditions, we observed that ASCmiR-210 inhibits apoptosis by modulating protein tyrosine phosphatase 1B (PTP1B) and death-associated protein kinase 1 (DAPK1). In hypoxic endothelial cells, EV-210 exerted its angiogenic capacity by inhibiting Ephrin A (EFNA3). Furthermore, EV-210 enhanced cell survival under the control of PTP1B and induced antiapoptotic effects in hypoxic H9c2 cells. In cardiac fibroblasts, the fibrotic ratio was reduced after exposure to EV-210, but EVs derived from ASCmiR-210 did not communicate with fibroblasts. Finally, we observed the functional restoration of the ischemia/reperfusion-injured heart by maintaining the intercommunication of EVs and cardiovascular cells derived from ASCmiR-210. These results suggest that the multiplexed target with ASCmiR-210 is a useful tool for cardiovascular regeneration.
The interplay of microRNAs and transcription factors in autophagy regulation in nonalcoholic fatty liver disease
Authors: Kim Yumi , Lee Da-Hye , Park So-Hyun , Jeon Tae-Il , Jung Chang Hwa 
Published: April 2021

AbstractThe autophagy-lysosomal degradation system has an important role in maintaining liver homeostasis by removing unnecessary intracellular components. Impaired autophagy has been linked to nonalcoholic fatty liver disease (NAFLD), which includes hepatitis, steatosis, fibrosis, and cirrhosis. Thus, gaining an understanding of the mechanisms that regulate autophagy and how autophagy contributes to the development and progression of NAFLD has become the focus of recent studies. Autophagy regulation has been thought to be primarily regulated by cytoplasmic processes; however, recent studies have shown that microRNAs (miRNAs) and transcription factors (TFs) also act as key regulators of autophagy by targeting autophagy-related genes. In this review, we summarize the miRNAs and TFs that regulate the autophagy pathway in NAFLD. We further focus on the transcriptional and posttranscriptional regulation of autophagy and discuss the complex regulatory networks involving these regulators in autophagy. Finally, we highlight the potential of targeting miRNAs and TFs involved in the regulation of autophagy for the treatment of NAFLD.
Salt-induced recruitment of specific root-associated bacterial consortium capable of enhancing plant adaptability to salt stress
Authors: Li Hong , La Shikai , Zhang Xu , Gao Lihong , Tian Yongqiang 
Published: April 2021

Abstract
Salinity is a major abiotic stress threatening crop production. Root-derived bacteria (RDB) are hypothesized to play a role in enhancing plant adaptability to various stresses. However, it is still unclear whether and how plants build up specific RDB when challenged by salinity. In this study, we measured the composition and variation in the rhizosphere and endophyte bacteria of salt-sensitive (SSs) and salt-resistant (SRs) plants under soil conditions with/without salinity. The salt-induced RDB (both rhizobiomes and endophytes) were isolated to examine their effects on the physiological responses of SSs and SRs to salinity challenge. Moreover, we examined whether functional redundancy exists among salt-induced RDB in enhancing plant adaptability to salt stress. We observed that although SSs and SRs recruited distinct RDB and relevant functions when challenged by salinity, salt-induced recruitment of specific RDB led to a consistent growth promotion in plants regardless of their salinity tolerance capacities. Plants employed a species-specific strategy to recruit beneficial soil bacteria in the rhizosphere rather than in the endosphere. Furthermore, we demonstrated that the consortium, but not individual members of the salt-induced RDB, provided enduring resistance against salt stress. This study confirms the critical role of salt-induced RDB in enhancing plant adaptability to salt stress.