bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of complications after the surgical removal of impacted mandibular third molars: A single center retrospective study
Authors: Prerana G , Tantry Deepa , Sougata Kumar , Sivalanka Sree Chandana Shreya 
Published: August 2021

Objectives:
The aim of the study was to study the incidence of complications associated with the surgical removal of impacted mandibular third molars in a single center.

Material and Methods:
A single center retrospective study was conducted in the Department of Oral and Maxillofacial Surgery at NSVK Sri Venkateshwara Dental College and Hospital located in Bannerughatta, Bengaluru. The study included patients between the ages of 15–60 years who had undergone surgical extraction of one or more mandibular third molar and had a difficulty score between 3 and 6 (Pederson’s difficulty index). During the course of study variables such as age, gender, impacted side, difficulty index, medical, and habit history along with complications and medications were recorded and accessed from the patient’s case history reports. In due course of the study, these variables were analyzed and correlated using descriptive analysis, Chi-square test, Contingency test, and regression analysis to understand whether or not these variables play an important role in aggravating post-extraction complications for mandibular third molars.

Results:
The study sample was composed of 250 patients with 52% female and 48% male with a mean age of 34 years. The complication rate observed was 7.6%, there was a statistically significant co-relation seen between gender (P = 0.016), age groups (p<0.05), spatial relationship (P = 0.019), and medical history (P = 0.016) when compared to the complications observed. The most common complications observed were trismus/muscle spasm followed by dry socket. However, the cases of neurosensory complications were extremely rare.

Conclusion:
There was a significant association to be found between the complication-rate and gender. Conditions such as muscle spasms/trismus and dry socket had a significant predilection toward the males while complications associated with neurosensory changes were commonly seen in females. There was also a significant association between habit history and rate of complication especially in conditions such as dry-socket where all the observed cases had positive history of tobacco/pan chewing habit. Interestingly all the males who complained of dry socket also had reported medical history of type (2) diabetes. Patients with complications such as neurosensory changes were few and could have been prevented with good surgical skills and precision; moreover, even if they were found they were temporary and treated with regular follow-ups.
Single nucleotide polymorphism rs1128446 ТXNRD1 is a novel genetic marker of cerebral stroke
Authors: Бушуева О.Ю. , Полоников А.В. , Иванов В.П. 
Published: August 2021

Мозговой инсульт (МИ) занимает третье место в структуре смертности во всем мире и является ведущим фактором снижения когнитивных функций и деменции. Окислительный стресс является ведущим механизмом повреждения головного мозга при ишемии и последующей реперфузии. Тиоредоксиновая система является наиболее важным антиоксидантным барьером клетки, способным регулировать ее окислительно-восстановительный статус. Целью исследования было изучение ассоциации однонуклеотидного полиморфизма rs1128446 гена эндогенного регулятора тиоредоксина ТXNRD1 с риском развития МИ. Материалом для исследования послужила выборка неродственных жителей Центральной России общей численностью 825 человек. В исследование были включены 375 пациентов с МИ (216 мужчин, 159 женщин; средний возраст 59,44±0,51 лет). Контрольную группу составили 450 относительно здоровых индивидуумов (249 мужчин, 201 женщина, средний возраст 61,69±0,38 лет) без кардио- и цереброваскулярных заболеваний в анамнезе и имеющих нормальный уровень артериального давления. Генотипирование SNP проводили методом ПЦР в режиме реального времени путем дискриминации аллелей с помощью TaqMan-зондов. Для анализа ассоциаций генотипов с развитием заболевания пользовались лог-аддитивной регрессионной моделью. Все расчеты выполнены относительно минорного аллеля; введены поправки на пол и возраст. SNP rs1128446 ТXNRD1 был связан с повышенным риском развития МИ (OR=1,89; 95% CI=1,48-2,43; p<0,0001). Проведенный биоинформатический анализ выявил высокий регуляторный потенциал данного SNP в тканях сердечно-сосудистой системы. Таким образом, впервые установлена ассоциация rs1128446 ТXNRD1 с развитием МИ.
Cerebral stroke (CS) is the leading factor in cognitive decline and dementia and ranks third in the structure of mortality worldwide. Oxidative stress is the basic mechanism of brain damage after cerebral ischemia-reperfusion. The thioredoxin system is the most important antioxidant barrier of the cell, capable of regulating its redox status. The aim of this study was to investigate the association of the common single nucleotide polymorphism rs1128446 in gene encoding the endogenous thioredoxin regulator TXNRD1 with the risk of CS. A total of 825 unrelated individuals from Central Russia were included for this study: 375 patients with CS (216 males, 159 females; 59.44±0.51 years old) and 450 healthy controls (249 males, 201 females, 61.69±0.38 years old). Genotyping was performed using TaqMan-based PCR. To analyze the associations of genotypes with the risk of diseases, a log-additive regression model was used. All calculations were performed relative to the minor allele; corrections for gender and age have been introduced. SNP rs1128446 TXNRD1 was associated with an increased risk of CS (OR=1.89; 95% CI=1.48-2.43; P<0.0001). Bioinformatic analysis revealed a high regulatory potential of this SNP in tissues of the cardiovascular system. Thus, for the first time, the association of rs1128446 TXNRD1 with the development of CS was revealed.
The interpretation of somatic genetic variants identified with high-throughput sequencing of DNA from paediatric solid tumors
Authors: Спектор М.А. , Ясько Л.А. , Друй А.Е. 
Published: August 2021

Активное внедрение высокопроизводительного секвенирования в клиническую практику требует общего подхода к интерпретации обнаруженных генетических вариантов, в частности, вариантов с соматическим статусом. В 2017 году Ассоциация молекулярной патологии США (AMP), Американская коллегия медицинской генетики и геномики (ACMG), Американское общество клинической онкологии (ASCO) и Коллегия американских патологов (CAP) опубликовали руководство по интерпретации соматических генетических вариантов и выдаче заключений по результатам высокопроизводительного секвенирования опухолевой ДНК. Данный обзор посвящен специфике применения руководства AMP/ACMG/ASCO/CAP для интерпретации результатов генетических исследований детских солидных опухолей. В статье приводятся критерии, на которых основана классификация соматических генетических вариантов, обсуждаются проблемы оценки клинической значимости генетических находок и приводятся примеры классификации генетических вариантов, выявленных в различных типах детских солидных опухолей.
Active clinical implementation of high-throughput DNA sequencing requires a common approach to the interpretation of detected genetic variants, including variants with somatic status. In 2017, the United States Association of Molecular Pathology (AMP), the American College of Medical Genetics and Genomics (ACMG), the American Society of Clinical Oncology (ASCO), and the College of American Pathologists (CAP) published the guidelines for interpreting and reporting the somatic genetic variants in cancer identified using high-throughput sequencing analysis. This review focuses on the specific application of the AMP/ACMG/ASCO/CAP guidelines in the field of genetic research on paediatric solid tumors. In particular, the review provides the criteria for classification of somatic genetic variants, discusses the problems of evaluating the clinical significance of genetic findings in paediatric tumors, and provides examples of classification of genetic variants specific for certain types of childhood solid malignancies.
Development of an approach to knockdown of DUX4 gene by siRNA in myoblasts derived from patients with FSHD
Authors: Кривошеева И. А. , Вяхирева Ю. В. , Табаков В. Ю. , Скоблов М. Ю. 
Published: August 2021

Миодистрофия Ландузи-Дежерина (МЛД) - распространённое наследственное заболевание, вызываемое эктопической экспрессией гена DUX4 в мышечных клетках. Метод подавления экспрессии генов при помощи siРНК зарекомендовал себя как эффективный и безопасный способ генной терапии без вмешательства непосредственно в геном. В данной работе мы продемонстрировали возможность трансфекции миобластов человека целевыми siРНК без ущерба жизнеспособности и дальнейшей дифференцировке этих клеток в миотубы. Также мы показали различия в профиле экспрессии генов-мишеней DUX4 между миобластами, полученными от здоровых людей и от пациентов с МЛД. В дальнейшем эти данные могут помочь при разработке эффективных и специфичных siРНК для терапии МЛД.
Facioscapulohumeral dystrophy (FSHD) is a common hereditary disease caused by ectopic expression of the DUX4 gene in muscle cells. The method of suppressing gene expression using siRNA has been shown to be an effective and safe method of gene therapy without interfering directly with the genome. In this work, we demonstrated the possibility of transfecting human myoblasts with targeted siRNAs without compromising the viability and further differentiation of these cells into myotubes. We also showed differences in the expression profile of DUX4 target genes between healthy and patient-derived myoblasts. In the future, these data can be used to develop effective and specific siRNAs for the treatment of FSHD.
Pathophysiological rationale of the use of microRNA in cardioand oncological diagnostics (review)
Authors: Калинкин М.Н. , Щеглова Н.Е. 
Published: August 2021

Многочисленные попытки изучить и доказать генетическую природу большинства заболеваний привели к открытию новых маркеров, в роли которых выступает класс так называемых «малых рибонуклеиновых кислот (РНК)» или микроРНК. В настоящем обзоре обсуждаются молекулярные механизмы сердечно-сосудистых и опухолевых заболеваний с участием микроРНК для возможного их использования в качестве диагностических и терапевтических мишеней.
Numerous attempts to study and prove the genetic nature of most diseases have led to the discovery of new markers, which are the class of so-called “small ribonucleic acids (RNA)” or microRNA. This review discusses the molecular mechanisms of cardiovascular and tumor diseases involving microRNAs and explores their possible use as diagnostic and therapeutic targets.
On some statements of nonlinear parabolic problems with boundary conditions of the first kind and on methods of their approximate solution
Authors: Гольдман Н.Л. 
Published: August 2021

Исследованы две постановки в классах Гельдера нелинейных задач для параболического уравнения с неизвестным коэффициентом при производной по времени. Одна постановка представляет собой систему, состоящую из краевой задачи с граничными условиями первого рода и из уравнения,задающего закон изменения по времени искомого коэффициента. В другой постановке требуется, кроме того, определить и граничную функцию в одном из краевых условий по дополнительной информации об этом коэффициенте, заданной в конечный момент времени. Для этих постановок обосновано построение приближенных решений на основе метода Ротэ и метода квазирешений.
We study two statements of nonlinear problems in H\"{o}lder spaces for a parabolic equation with an unknown coefficient at the time derivative and the boundary conditions of the first kind. One statement is a system containing a boundary value problem and an equation for the time dependence of the sought coefficient. In the other statement, in addition it is necessary to determine a boundary function in one of the boundary conditions by using an additional information on this coefficient at a final time. For these statements we justify a construction of approximate solutions on the basis of the Rothe method and the method of quasisolutions.
Inverse problems of experimental data interpretation in 3D ultrasound tomography
Authors: Гончарский А.В. , Кубышкин В.А. , Романов С.Ю. , Серёжников С.Ю. 
Published: August 2021

Обратная задача 3D ультразвуковой томографии рассматривается в статье как нелинейная коэффициентная обратная задача для уравнения гиперболического типа. Используемая математическая модель хорошо описывает как дифракционные эффекты, так и поглощение ультразвука в неоднородной среде. В рассматриваемой постановке реконструируется скорость распространения акустической волны как функция трех координат. Количество неизвестных в нелинейной обратной задаче составляет порядка 50 миллионов. Разработанные итерационные алгоритмы решения обратной задачи ориентированы на использование GPUкластеров. Основным результатом работы является апробация алгоритмов на экспериментальных данных. В эксперименте использовался стенд для 3D ультразвуковых томографических исследований, разработанный в МГУ имени М.В. Ломоносова. Акустические параметры фантомов близки к акустическим параметрам мягких тканей человека. Объем экспериментальных данных составляет порядка 3 ГБ. Интерпретация данных эксперимента позволила не только продемонстрировать эффективность разработанных алгоритмов, но и подтвердила адекватность математической модели реальности. Для реализации разработанных численных алгоритмов использовался графический кластер суперкомпьютера Ломоносов-2.
The inverse problem of 3D ultrasound tomography is considered in this paper as a nonlinear coefficient inverse problem for a hyperbolic equation. The employed mathematical model accurately describes the effects of ultrasound wave diffraction and absorption in inhomogeneous media. The velocity of acoustic waves inside the test sample is reconstructed as an unknown function of three spatial coordinates. The number of unknowns in the nonlinear inverse problem reaches 50 million. The developed iterative algorithms for solving the inverse problem are designed for GPU clusters. The main result of this study is testing the developed algorithms on experimental data. The experiments were carried out using a 3D ultrasound tomographic setup developed at Lomonosov Moscow State University. Acoustic properties of the test samples were close to those of human soft tissues. The volume of data collected in experiments is up to 3 GB. Experimental results show the efficiency of the proposed algorithms and confirm that the mathematical model is adequate to reality. The proposed algorithms were tested on the GPU partition of Lomonosov2 supercomputer.
On the approximation error in the problems of conjugate convective heat transfer
Authors: Мартыненко С.И. 
Published: August 2021

Рассмотрено влияние малых возмущений границы области на погрешность аппроксимации модельной краевой задачи. Показано, что игнорирование малых возмущений границы приводит к дополнительной погрешности аппроксимации исходной дифференциальной задачи, не связанной с шагом сетки. Полученные результаты представляют интерес для математического моделирования сопряженного теплообмена, моделирования течений с поверхностными химическими реакциями и других приложений, связанных с течениями рабочих сред вблизи шероховатых поверхностей.
The effects of small boundary perturbation on the approximation error for a model boundary value problem are considered. It is shown that the ignorance of small perturbations of the boundary leads to an additional approximation error in the original differential problem. This error is independent of mesh size. The obtained results are of interest for the mathematical modeling of conjugate heat transfer, the modeling of flows with surface chemical reactions and other applications related to fluid flows near rough surfaces.
Cartas ao mar... De experiências que nos habitam: Narrativas de formação docente
Authors: HenriquesÂ  Eda Maria de Oliveira , Azevedo Mônica Maria de 
Published: August 2021

Este trabalho pretende, através de um relato parcial de seu desenvolvimento e resultados, discutir e analisar a importância das narrativas de formação de professores no âmbito da pesquisa educacional. Nessa perspectiva, a pesquisa aqui relatada foi realizada em uma escola da rede pública de ensino do DF, Brasília, que atende o segmento do ensino fundamental de primeiro ao quinto ano e buscou identificar e analisar concepções de professores de ensino básico sobre suas experiências de leitura ao longo de sua trajetória escolar, bem como compreender a existência ou não de um diálogo destas com suas práticas pedagógicas atuais no ensino de leitura. Nessa direção, utilizou-se um enfoque de pesquisa baseado em narrativas de formação e escritas de si através de temas e propostas relacionados aos objetivos da pesquisa. Uma dessas propostas consistiu num pedido aos professores que escrevessem uma carta a professores que tenham sido, de alguma forma, marcantes no que diz respeito ao ensino e Ã aprendizagem da leitura. Nesta perspectiva, para ampliarmos essa discussão, traremos a contribuição de Benjamin, que vai aprofundar as relações entre experiência e narrativa, e de Vygotsky e Bakhtin, que compreendem a linguagem como organizadora do pensamento e planejadora da ação, permitindo um distanciamento dos acontecimentos imediatos e da nossa própria vida. O fato dos professores terem privilegiado situações não diretamente relacionadas a processos de ensino e aprendizagem da leitura, mas a aspectos da relação professor e aluno, pode indicar que para estes docentes tais relações parecem ter um maior peso nas suas trajetórias de formação.
Metodologia qualitativa de pesquisa sobre a produção de sentidos intergeracional em comunidades rurais e quilombolas: entrevistas narrativas e argumentações
Authors: Santos Júlio César dos , Ramos Patrícia Campos 
Published: August 2021

A articulação de diferentes métodos possibilita narrativas que perfazem as interpretações de si nas transições. A construção de explicações de si, nas narrativas, possibilita a identificação de mudanças de posicionamentos dos antepassados Ã s gerações seguintes. Utilizamos como instrumentos as entrevistas: (a) de história de vida; (b) episódica; (c) semiestruturada, mediada por fotografias/objetos. Realizamos as análises temática, pragmática do discurso e a produção de sentidos. Observamos processos de negociação de conflitos de si com os outros, como também de si consigo mesmo. Concluímos que diferentes métodos colaboram para a identificação da produção de sentidos intergeracional.
A fala egocêntrica utilizada pela criança em atividade escolar de escrita
Authors: Cavaton Maria Fernanda Farah 
Published: August 2021

Objetivamos pesquisar a fala egocêntrica utilizada por quatro crianças de seis anos ao soletrar em atividades de escrita livre. A função auto organizadora dessa fala está embasada na teoria vigotiskiana que discute a relação pensamento e fala. Numa abordagem quali-quanti de pesquisa, analisamos três sessões individuais com cada criança gravadas em vídeo, anotando a frequência de uso dessa fala e analisando cada processo de escrita. Os resultados mostraram a construção da escrita como um processo mediado pela relação escrita e fala egocêntrica. Duas crianças falaram mais e produziram mais, sendo as demais, uma já alfabetizada e outra pouco produziu. A fala egocêntrica de repetir sons de letras favorece a consciência fonêmica e a busca na memória da palavra a ser escrita. Portanto, as falas desempenham funções importantes em atividades escolares.
Eixos de convergência da alfabetização científica e técnica no ensino médio integrado
Authors: Rodrigues-Moura Sebastião , Brito Licurgo Peixoto de 
Published: August 2021

Com o finalidade de analisar e discutir os indicadores atuais da etapa final da educação básica no Brasil frente às propostas de sua reformulação, elencamos e analisamos eixos de convergência para à promoção da Alfabetização Científica e Técnica no ensino médio integrado a estudantes que almejam uma formação mais consolidada com o papel cidadão, aborde temas socialmente relevantes, vislumbre decisões a serem tomadas frente a situações-problemas do cotidiano, bem como destaque seu papel de protagonista na sociedade. Para tanto, ocupamo-nos em abordar reflexões iniciais sobre indicadores de desempenho dos estudantes e o atual panorama do ensino médio no Brasil, destacando ao longo do texto a proposição de um curso integrado, defendida por pesquisadores da educação brasileira. Com enfoque metodológico qualitativo, com caráter exploratória, do tipo documental, analisamos Ã luz da Análise Textual Discursiva (ATD) documentos oficiais de cursos técnicos integrados ao ensino médio de uma instituição federal de ensino no contexto amazônico-paraense, na busca de elementos de aproximação em educação, ciência e sociedade com vistas à ACT. Dessa análise emergiram quatro eixos de convergência, identificados como a (i) Prioridade a uma formação humanística e reflexiva, (ii) Elementos de interdisciplinaridade e contextualização, (iii) Formação para a cidadania, e (iv) Investigação social para a tomada decisões conscientes. Desses eixos, observamos, notadamente, que os resultados obtidos apresentam uma aproximação para a discussão, debate e fomento à educação, à ciência e a elementos de questões sociais para a formação regional.
Espaços e tempos de escolarização: marcas dos dispositivos disciplinares
Authors: Schüt Monique Cristina Francener Hammes , Cervi Gicele Maria 
Published: August 2021

O objeto de estudo é a escola. O artigo problematiza como a escola contemporânea e nela o dispositivo disciplinar da vigilância produzem efeitos sobre os corpos. Trata-se de uma pesquisa pós-crítica. Os instrumentos de produção de dados foram: fotografias e o diário de campo. Infere-se que a escola é uma maquinaria, que através do dispositivo disciplinar da vigilância produz, na instituição pesquisada, corpos que se movimentam, mas que silenciam, são obedientes, consumistas, participativos, polícia de si e dos outros, corpos que se encontram, que resistem e constroem linhas de fuga.
Perspectivas em etnomatemática para a formação e atuação docente na Educação de Jovens e Adultos
Authors: Freitas Adriano Vargas 
Published: August 2021

O artigo apresenta recorte de pesquisa desenvolvida no modelo de estado da arte. Destacamos publicações envolvendo análises e contribuições da Educação Matemática voltada para a EJA. O objetivo foi contribuir para o conhecimento e o enfrentamento de grandes desafios da EJA, especialmente os relacionados Ã formação do docente que atua nesta modalidade. Os resultados destacam as bases do Programa Etnomatemática como possibilidade de melhoria da qualidade do processo educacional da EJA, e sua influência sobre a formação/atuação dos profissionais que atuam nesta modalidade de ensino de modo a torná-la mais eficaz e adequada Ã s expectativas e especificidades de seus alunos.
AGENDA OF RURAL EMPLOYMENT THROUGH MGNREGA: A CASE OF HARYANA (INDIA)
Authors: Kaur Tarminder 
Published: August 2021

The paper is intended to comprehensively analyze the concern of Government for rural development and its various efforts to contain rural problems. Most of all the efforts since independence, MGNREGA is emerged as a milestone and unique initiative to tackle rural poverty through 100 days rural employment. An effort is done to assess the performance of MGNREGA through financial investments in last five years. The actual results have been seen in the form of observing the amount siphoned for labour budget out of total budgetary outlay. Further, to review the social implications, the disadvantaged sections of SCs (Scheduled Caste) and women are specifically considered as beneficiaries.