bluuebunny/crossref_metadata_2025_split huggingface dataset:
Service Migration Algorithm Based On Markov Decision Process With Multiple QoS Attributes
Authors: Ma Anhua , Pan Su , Tao Shuai , Zhou Weiwei 
Published: October 2021

Abstract
With the rapid development of mobile internet cloud computing, the traditional network structure becomes non-suitable for advanced network traffic requirements. A service migration decision algorithm is proposed in the Software Defined Network(SDN) to satisfy differential Quality of Service(QoS) requirements. We divide services into real-time ones and non-real-time ones due to their different requirements on time delay and transmission rates, and construct the revenue function on two QoS attributes i.e. time delay and available transmission rates. We use the Markov decision process to maximize the overall benefits of users and network system to achieve the best user experience. The simulation results show that our proposed algorithm achieves better performance in terms of overall benefits than the exiting algorithms only considering single service and single QoS attribute.
Cascade process mediated by left hippocampus and left superior frontal gyrus affects relationship between aging and cognitive dysfunction
Authors: Kokudai Yumika , Honma Motoyasu , Masaoka Yuri , Yoshida Masaki , Sugiyama Haruko , Yoshikawa Akira , Koiwa Nobuyoshi , Kubota Satomi , Iizuka Natsuko , Wada Sayaka , Kamijo Shotaro , Uchida Yuki , Yano Satoshi , Ida Masahiro , Ono Kenjiro , Izumizaki Masahiko 
Published: October 2021

Abstract
Background: Cognitive function declines with age and has been shown to be associated with atrophy in some brain regions, including the prefrontal cortex. However, the details of the relationship between aging and cognitive dysfunction are not well understood.Methods: Across a wide range of ages (24- to 85-years-old), this research measured the gray matter volume of structural magnetic resonance imaging data in 39 participants, while some brain regions were set as mediator variables to assess the cascade process between aging and cognitive dysfunction in a path analysis.Results: Path analysis showed that age affected the left hippocampus, thereby directly affecting the left superior frontal gyrus. Furthermore, the gyrus directly affected higher order flexibility and maintenance abilities calculated as assessed in the Wisconsin card sorting test, and the two abilities affected an assessment of general cognitive function. Conclusion: Our finding suggests that a cascade process mediated by the left hippocampus and left superior frontal gyrus is involved in the relationship between aging and cognitive dysfunction.
Prognostic Impact of Pneumonitis After Durvalumab Therapy in Patients With Locally Advanced Non-small Cell Lung Cancer
Authors: Nishimura Ari , Ono Akira , Wakuda Kazushige , Kawabata Takanori , Yabe Michitoshi , Miyawaki Taichi , Miyawaki Eriko , Kodama Hiroaki , Nishioka Naoya , Mamesaya Nobuaki , Kobayashi Haruki , Omori Shota , Kenmotsu Hirotsugu , Naito Tateaki , Murakami Haruyuki , Harada Hideyuki , Takahashi Toshiaki 
Published: October 2021

Abstract
Background: Prognostic data on Japanese patients receiving durvalumab after chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer (LA-NSCLC) are insufficient. Whether pneumonitis has prognostic implications in patients with LA-NSCLC who have received durvalumab also remains unclear.Methods: We retrospectively assessed the data of 82 patients who had received durvalumab after CRT at our institution between May 2018 and August 2020. A multi-state model was used to establish the associations between co-variables and progression-free survival (PFS).Results: The median observation period for all the censored cases was 14.5 months (5.7-28.9 months), the median PFS was 22.7 months, and the 12-month PFS rate was 62.3% (95% CI: 50.2%-72.3%). The median percentage of the lung volume receiving a radiation dose in excess of 20 Gray (V20) was 22% (4%-35%). Thirteen patients (16%) had Grade 1 pneumonitis before receiving durvalumab, and 62 patients developed pneumonitis after durvalumab (Grades 1, 2, and 3 in 25 [30%], 32 [39%], and 4 [5%], respectively). Twenty-four patients (29%) completed the 1-year durvalumab treatment period, 16 patients (20%) were continuing to receive treatment, and 42 (51%) had discontinued treatment. In a multi-state analysis, patients with pneumonitis before durvalumab therapy had a poorer PFS than those without pneumonitis (HR: 4.29, p = 0.002). The development of Grade 2 or higher pneumonitis after durvalumab was not a significant prognostic factor for PFS (HR: 0.71, p = 0.852).Conclusion: Grade 2 or higher pneumonitis after durvalumab was not a prognostic factor of PFS in LA-NSCLC patients received durvalumab.
Pigmentation Effects of Kaliziri Standard Extracts on Melanocytes, C57BL/6 mice of Hydroquinone- Induced and Guinea Pigs of Hydrogen Peroxide-Induced Hyperpigmentation Model
Authors: Zang Deng , Maimaiti Zulipiya , Mamat Nuramina , Ma Xiaoling , Li Haorong , Lu Xueying , Turak Ablajan , Luo Yuqin , Aisa Haji Akber 
Published: October 2021

Abstract
Background: Vitiligo is a depigmentation disorder characterized by losing functional melanocytes, leading to skin and/or hair depigmentation. Kaliziri (Vernonia anthelmintica (L.) Willd) seeds have been traditionally used to treat pigmentation disorders in Central Asia. The extracts of these seeds increased melanin content and tyrosinase activity and upregulated melanogenesis-related proteins in B16 melanoma cells. We isolated the main active compound Kaliziri standard Extracts (encoded as CAM-Y7) from the Kaliziri seeds in a previous study. Our goal was to reveal whether CAM-Y7 promotes melanogenesis in melanocytes and restored pigmentation in animal models of vitiligo. Methods: Herein, we analyzed the melanogenic effects of CAM-Y7 on melanocytes and the skin pigmentation of hydroquinone (H.Q.)-induced mouse model and hydrogen peroxide (H2O2)-induced guinea pig model of vitiligo. Results: CAM-Y7 promotes Melanogenesis up-Regulation MITF-induced Tyrosinase Expression via p38MAPK signal pathway in melanocytes. Oral administration of CAM-Y7 progressively darkened the dorsal skin and hair of the C57BL/6 mice and guinea pigs. Lillie staining and hematoxylin-eosin staining further showed that CAM-Y7 induced melanogenesis in the epidermis and hair follicles of the animals. Conclusion: Taken together, these results suggest that CAM-Y7 regulation of melanogenesis may be mediated by the activation of p38 MAPK and restored pigmentation in an HQ-Induced C57BL/6 mouse and H2O2-induced guinea pig models of vitiligo. CAM-Y7 might be valuable and promising therapeutic as an agent for vitiligo. Subsequent clinical experiments using are needed to verify our results.
Risk Factors and Management Strategies of Cerebrospinal Fluid Leakage Following Lumbar Posterior Surgery
Authors: tang jin , lu qilin , li ying , wu congjun , li xugui , gan xuewen , xie wei 
Published: October 2021

Abstract
Objective: To analyze the risk factors of cerebrospinal fluid leakage(CSFL) following lumbar posterior surgery and summarize the related management strategies. Methods: A retrospective analysis was performed on 3179 patients with CSFL strategies lumbar posterior surgery in our hospital from January 2019 to December 2020. There were 807 cases of lumbar disc hemiation(LDH), 1143 cases of lumbar spinal stenosi (LSS), 1122 cases of lumbar spondylolisthesis(LS), 93 cases of lumbar degenerative scoliosis(LDS),14 cases of lumbar spinal benign tumor(LST). Data of gender, age, body mass index(BMI), duration of disease, diabete,smoking history, preoperative epidural hormone injection, number of surgical levels, surgical methods (total laminar decompression, fenestration decompression), revision surgery, extubation time, suture removal time, and complications were recorded.Results: The incidence of 115 cases with cerebrospinal fluid leakage,was 3.62% (115/3179).One-way ANOVA showed that gender, body mass index(BMI), smoking history, combined with type 2 diabetes and surgical method had no significant effect on CSFL(P >0.05). Age, type of disease, duration of disease, preoperative epidural hormone injection, number of surgical levels and revision surgery had effects on CSFL(P<0.05). Multivariate Logistic regression analysis showed that type of disease, preoperative epidural hormone injection, number of surgical levels and revision surgery were significantly affected CSFL(P<0.05), and duration of disease and age of the patients were not significantly affected CSFL (P >0.05).The extubation time of CSFL patients ranged from 7 to 11 days, with an average of 7.11±0.48 days, the extubation time of patients without CSFL was 1-3 days, with an average of 2.02±0.13 days, and there was a statistical difference between the two groups(P < 0.05).The removal time of CSFL patients was 12-14 days, with an average of 13.11±2.67 days, and the removal time of patients without CSFL was 10-14 days, with an average of 12.87±2.19 days, there was no statistically significant difference between the two groups (P>0.05). Conclusion: Type of disease, preoperative epidural hormone injection, number of surgical levels and revision surgery were the risk factors for CSFL. Effective prevention were the key to CSFL in lumbar surgery.Once appear, CSFL can also be effectively dealt with without obvious adverse reactions after intraoperative effectively repair dural, head down, adequate drainage after operation, the high position, rehydration treatment, and other treatments.
Comparative Studies of Carbon Materials Synthesized From Waste as Catalysts for Ozonation of Real Textile Wastewater
Authors: Juwar Vijay A. , RATHOD AJIT , Kodape Shyam M. 
Published: October 2021

Abstract
In the present work, evaluation of two catalysts, Activated carbon (AC) synthesized from agricultural waste and Multiwalled carbon nanotubes (MWCNT) synthesized from plastic waste, were done for the ozonation of real textile wastewater using para- chloro benzoic acid (p-CBA) as a probe compound. The effect of pH and catalyst dose were studied in terms of •OH exposure, Rct, rate of p-CBA degradation and ozone degradation. The rate constant for the reaction of organic matter with hydroxyl radicals was determined using competition kinetics. The threshold ozone dose for real textile wastewater was found to be 0.51 gm/gm of TOC. With an increase in specific ozone dose, the rate of p-CBA degradation was found to be increasing and has shown a positive effect on •OH exposure and Rct. The increasing pH had shown a positive effect on the rate of degradation and decomposition of p-CBA and ozone respectively in the case of AC catalyzed ozonation. A similar trend was observed in the case of MWCNTs catalyzed ozonation. A positive effect of pH was observed on •OH exposure and Rct, in AC as well as MWCNTs catalyzed ozonation. The effect of catalyst loading has shown significant enhancement in p-CBA degradation, ozone decomposition, •OH exposure and Rct in both AC as well as MWCNTs catalyzed ozonation. However, MWCNTs have proved better than AC as a catalyst for ozonation in studied experimental parameters.
Full-length Transcriptome Reconstruction Reveals Genetic Differences in Hybrids of Oryza Sativa and Oryza Punctata With Different Ploidy and Genome Compositions
Authors: He Wenting , Zhang Xianhua , Lv Pincang , Wang Wei , Wang Jie , He Yuchi , Song Zhaojian , Cai Detian 
Published: October 2021

Abstract
Background: Allopolyploid breeding is an efficient technique for improving the low seeding rate of autotetraploids in plant breeding and one of the most promising breeding methods. However, there have been few comprehensive studies of the posttranscriptional mechanism in allopolyploids.Results: By crossing cultivated rice (Oryza sativa, genome AA) with wild rice (Oryza punctata, genome BB), we created hybrid rice lines with different ploidy and genome compositions [diploid F01 (AB), allotetraploid F02 (AABB) and F03 (AAAB)]. The genetic differences of the hybrids and the mechanism of allopolyploid breeding dominance were revealed through morphological and cytological observations and single molecule real-time sequencing techniques. The tissues and organs of allotetraploid rice F02 exhibited "gigantism" and the highest levels of fertility. The numbers of non-redundant transcripts, gene loci and new isoforms in the polyploid rice lines were higher and the isoform lengths greater than those of the diploid line. Moreover, alternative splicing (AS) events occurred twice as often in the polyploid rice lines than the diploid line. During these events, intron retention dominated. Furthermore, a large number of new genes and isoforms specific to the lines of different ploidy were discovered. Conclusions: The results indicated that alternative polyadenylation (APA) and AS events contributed to the complexity and superiority of polyploids in the activity of translation regulators, nucleic acid binding transcription factor activities and the regulation of molecular function. Therefore, these APA and AS events in allopolyploid rice were found to play a role in regulation. Our study provides new germplasm for polyploid rice breeding and reveals complex regulatory mechanisms that may be related to heterosis and fertility.
Association between glycemic control and risk of venous thromboembolism in diabetic patients: A nested case-control study
Authors: Charlier Sarah H R , Meier Christian , Jick Susan S , Meier Christoph R , Becker Claudia 
Published: October 2021

Abstract
Background:Previous studies suggested an elevated risk of venous thromboembolism (VTE) among patients with type 2 diabetes mellitus (T2DM), with a possible sex difference. The impact of glycemic control on the risk of VTE is unclear. Our objective was to analyze the association between glycemic control and the risk of unprovoked (idiopathic) VTE in men and women with T2DM.Methods:We conducted a nested case-control analysis (1:4 matching) within a cohort of patients with incident T2DM between 1995–2019 using data from the CPRD GOLD. We excluded patients with known risk factors for VTE prior to onset of DM. Cases were T2DM patients with an unprovoked treated VTE. The exposure of interest was glycemic control measured as HbA1c levels. We conducted conditional logistic regression analyses adjusted for several confounders.Results:We identified 3’896 VTE cases and 15’584 controls (56% females). We found no association between the HbA1c level and the risk of VTE in our main analysis. However, when the most recent HbA1c value was within 90 days before the index date, women with HbA1c levels > 7.0% had an 18–35% increased relative risk of VTE when compared to women with HbA1c > 6.5-7.0%.Conclusions:Our study raises the possibility that female T2DM patients with HbA1c levels > 7% may have a slightly higher risk for unprovoked VTE compared to women with HbA1c level > 6.5-7.0%. This increase may not be causal and may reflect differences in life style or other characteristics. We observed no effect of glycemic control on the risk of VTE in men.
Breaking the “hard-to-abate” bottleneck in China’s path to carbon neutrality
Authors: Yang Xi , Nielsen Chris , Song Shaojie , McElroy Michael , Wang Xiaoyang 
Published: October 2021

Abstract
Countries such as China are facing a bottleneck in paths to carbon neutrality: abating emissions in heavy industries and heavy-duty transport. There are few in-depth studies of the prospective role for clean (green/blue) hydrogen in these “hard-to-abate” (HTA) sectors. Are current mitigation technologies in HTA sectors effective? What are the roles for clean hydrogen towards carbon neutrality? We carry out an integrated modeling analysis to answer these questions. Results show that, first, clean hydrogen as both energy carrier and feedstock can significantly reduce heavy industry emissions. Second, clean hydrogen can fuel up to 50% of China’s heavy-duty truck and bus fleets by 2060 together with significant shares of shipping. As a side benefit, a realistic hydrogen scenario, reaching 65.7 Mt of production in 2060, could avoid $1.72 trillion new investment cost compared to a no-hydrogen scenario. This study provides strong evidence for countries facing challenges similar to China in addressing requirements to reduce emissions from their recalcitrant HTA sectors towards carbon neutrality.
SIRT3 Protects Against Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy via JNK/p66Shc-Regulated Mitochondrial Apoptosis in Mice
Authors: Lyu Zhuochen , Luo Shiyuan , Li Yinjiao , Yao Liangfang , Chen Feng , Tu Qing , Yuan Yuan , Li Jinbao , Luo Yan 
Published: October 2021

Abstract
Background
Sepsis-associated encephalopathy (SAE) is one of the severe central nervous system complications. Oxidative stress and synaptic dysfunction were involved in cognitive impairment induced by SAE. The mitochondrial nicotinamide adenine dinucleotide (NAD+) dependent deacetylase, sirtuin3 (SIRT3), plays a critical role in regulating mitochondrial function. The aim of this study was to evaluate the effect of SIRT3 in cognitive dysfunction induced by SAE.
Methods
Mice were treated with lipopolysaccharide (LPS, 10 mg/kg, i.p.). Contextual and cue memory were evaluated by fear conditioning test in wild-type (WT) and SIRT3-deficient (SIRT3-/-) mice. Synapse-associated proteins and mitochondrial apoptosis-associated protein were examined by western blotting. In vitro studies, acetylation levels of cyclophilin D (CypD) were detected with different SIRT3 deacetylase activity in HT22 cells after LPS-induced microglia supernatant (Mi-sup) exposure. Oxidative stress was detected by reactive oxygen species (ROS) staining, and mitochondrial membrane potential (MMP) was detected by JC-1 staining, and mitochondrial membrane permeability transition pore (MPTP) opening was detected by Calcein and Co2+ staining. Furthermore, the phosphorylation levels of mitochondrial p66Shc and JNK were evaluated by western blotting.
Results
SIRT3 expression was diminished in hippocampus of mice after LPS treatment. SIRT3-deficiency contributed to more severe contextual memory loss and synaptic dysfunction, decreased ratio of Bcl-2/Bax and increased Cyt C release to cytoplasm in hippocampus compared with wild-type controls. In HT22 cells, lysine acetylation levels of CypD were significantly increased after Mi-sup exposure and further enhanced with 3-TYP (SIRT3 deacetylation inhibitor) pretreatment, in association with the accumulation of ROS, declined MMP and increased MPTP opening, as well as the increased mitochondrial Cyt C release and phosphorylation levels of mitochondrial JNK and p66Shc-Ser36. SIRT3 overexpression restored CypD lysine acetylation levels and MPTP opening in HT22 cells after Mi-sup exposure and reduced mitochondrial JNK and p66Shc activation.
Conclusion
Taken together, our results showed that SIRT3-mediated CypD deacetylation was involved in LPS-induced hippocampal synaptic dysfunction, via ROS accumulation, declined MMP, increased MPTP opening, mitochondrial Cyt C release and mitochondrial apoptosis of hippocampal neuron via JNK/p66Shc pathway. Our results revealed that SIRT3 may be a promising therapeutic and diagnostic target for cognitive dysfunction induced by SAE.
Palmitate Enhances The Efficacy of Cisplatin And Doxorubicin Against Human Endometrial Carcinoma Cells
Authors: Wu Zihsyuan , Huang Shinming , Wang Yuchi 
Published: October 2021

Abstract
Background: Endometrial cancer is the most common gynecological cancer worldwide. Overexpression of fatty acid synthase is a common molecular feature of a subgroup of sex steroid-related cancers associated with poor prognoses, including endometrial cancers. The saturated fatty acid palmitate reportedly induces lipotoxicity and cell death by inducing oxidative stress in many cell types. Here, we explored the effects of palmitate combined with doxorubicin or cisplatin in the HEC-1-A and RL95-2 human endometrial cancer cell lines. Methods: Endometrial cancer cells were cultured with in vitro and treated with palmitate, doxorubicin, and cisplatin. Cell metabolic activity and combination index was measured using MTT assay. Protein expression was assessed with western blotting. Flow cytometry was used to examine the cell cycle profiles, cell proliferation, apoptosis, ROS, mitochondria membrane potential, and mitochondrial mass. Immunocytochemistry was used to investigate the mitochondrial morphology.Results: Physiological concentrations of exogenous palmitate significantly increased cell cycle arrest, DNA damage, autophagy and apoptosis in both RL95-2 and HEC-1-A cells. It also increased the chemosensitivity of both cell types. Notably, we did not observe that palmitate lipotoxicity reflected increased levels of reactive oxygen species, suggesting palmitate acts via a different mechanism in endometrial cancer.Conclusion: This study provides a potential therapeutic strategy in which palmitate is used as an adjuvant in the treatment of endometrial cancer.
Mentalization and Dissociation after Adverse Childhood Experiences
Authors: Wagner-Skacel Jolana , Riedl David , Kampling Hanna , Lampe Astrid 
Published: October 2021

Abstract
Background: Impairment of mentalization may impact coping strategies, regulation of affect and stress. So far, little is known about the influence of impaired mentalization on dissociation in patients with adverse childhood experiences (ACEs). The aim of this study is to assess the relationship between ACEs, mentalizing and dissociation in adult individuals.
Methods: Sixty-seven patients with ACEs completed the Mentalization Questionnaire (MZQ), the Essener Trauma Inventory (ETI) and the Brief Symptom Inventory-18 (BSI-18). The SPSS PROCESS macro tool was applied to test if mentalization mediated the relationship of ACEs and dissociation.
Results: ACEs were significantly associated with higher dissociation (β=.42, p<.001) and lower mentalization (β=-.49, p<.001). When mentalization was added to the model as a predictor, the association of ACEs with dissociation was no longer significant (β=.11, p=.31) and a statistically significant indirect effect was found (β=.32, 95% CI: .16-.47). The overall explained variance of dissociation notably improved after inclusion of mentalization (17.5% to 49.1%). Thus, the results indicated that the association of ACEs on dissociation was fully mediated by mentalization.
Conclusion: Our results suggest that ACEs are associated with lower mentalization and higher dissociation. Lower mentalization was also associated with worse depression, anxiety, somatization and PTSD symptoms. These findings underline the increasing importance of early treatment of individuals affected by ACDs with a focus to foster the development of mentalization.
Microbial Cysteine Degradation Drives Cryptic Sulfide Redox Chemistry in the Gut
Authors: Wolfson Sarah , Hitchings Reese , Peregrina Karina , Cohen Ziv , Khan Saad , Yilmaz Tugba , Malena Marcel , Goluch Edgar , Augenlicht Leonard , Kelly Libusha 
Published: October 2021

Abstract
Although microbial biochemistry shapes a dynamic environment in the gut, how bacterial metabolites such as hydrogen sulfide (H2S) mechanistically alter the gut chemical landscape is poorly understood. Here we show for the first time that H2S generated during cysteine metabolism drives the reduction of azo (R-N=N-R’) xenobiotics in bacterial cultures, human fecal microbial communities, and in vivo mouse models. Thus, chemical-chemical interactions, derived from microbial community metabolism, are a key missing feature shaping xenobiotic metabolism in the gut. Changing dietary levels of the H2S xenobiotic redox partner Red 40 transiently decreases mouse fecal sulfide, confirming that a xenobiotic can attenuate sulfide concentration in vivo. Cryptic H2S redox thus modulates sulfur homeostasis in the gut and the fate of xenobiotics to which humans are regularly exposed.