bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glitter Interference On Photosynthetic Rates of A Submerged Macrophyte (Egeria Densa)
Authors: Yoshida Luana Lume , Bianchini Irineu , Cunha-Santino Marcela Bianchessi da 
Published: September 2021

Abstract
This study analyzed the photosynthetic rates (by the light and dark bottle method) of the submerged macrophyte Egeria densa in the presence of three concentrations of glitter: 0.0235 g (T1/T4), 0.0117 g (T2/T5) and 0.0058 g (T3/T6), as well in its absence (control treatment, CT1 and CT2). About 800 apical fragments of E. densa were distributed in 8 subtreatments (4 under light conditions and 4 in the dark to obtain respiration), with 100 specimens in each. The CT showed the highest net photosynthesis rate (PN = gross photosynthetic (PG) rate subtracted from respiration (RD)) of E. densa, with 59.3%, 32.8%, 13.0% higher compared to T1, T2 and T3, respectively. At T3 it was observed the highest mean respiration rate (RE) o E. densa and at T1, the lowest. Comparing PN with RD, we found that the photosynthetic process was, on average 3.5, 2.47, and 2.93 times higher in CT, T1, T2, and T3, respectively. The presence of glitter may have increased the reflectance of water, as it is a suspended particle and reflected light intensely, considering that it is a metal coated particle. Glitter reflects radiation, decreasing the light absorption process, compromising the use of underwater radiation by E. densa. The microplastic interferes with the absorption of light necessary for photosynthetic processes, reducing them, enabling an imbalance in the ecosystem.
Exploring the relationship between the urban built environment and elderly pedestrian mobility in South Asian cities
Authors: Parida Debadutta , Khan Rahaman Rubayet , K Neethilavanya 
Published: September 2021

Abstract
Cities in South Asia have traditionally been dominated by pedestrians for their daily trips. As the elderly population is increasing in the last two decades, the dynamics of designing appropriate walkways to serve elderly people are getting more attention from urban planning scholars and policymakers alike. However, few studies in planning in the context of southern cities have considered the significant issue of elderly mobility and walkability in cities in South Asia beyond the realm of large metropolitan cities. In this paper, we attempt to understand the challenges encountered by elderly pedestrians in existing street conditions and summarizes information that may be useful for enhancing elderly mobility. Using cases of Rourkela in India and Khulna city in Bangladesh, we have collected both primary and secondary information by conducting a structured questionnaire survey in both cities at a similar period. Further to this, we analyzed statistical models to understand relationships among built environment and mobility issues based on subjective evaluation (i.e., infrastructure, street design, lighting, overcrowding condition, and encroachment). Most of the elderly pedestrians surveyed in both cities demand improvement of micro-scale urban design features and planning guidelines that they assume are absent in the statutory planning documents. This study may be employed as a useful document for city-level planning taking into account elderly perception about the built environment and their mobility concerns in future policy and planning projects. Consequently, a more comprehensive study may be incorporated highlighting elderly pedestrian’s mobility within the formal/informal transportation planning system.
Electronic regulation of Ni single atom by confined Ni nanoparticles for fast and energy-efficient CO2 electroreduction
Authors: Ren Wenhao , Tan Xin , Jia Chen , Krammer Anna , Sun Qian , Qu Jiangtao , Smith Sean , Schueler Andreas , Hu Xile , Zhao Chuan 
Published: September 2021

Abstract
Electrocatalytic CO2 to CO conversion is approaching the industrial benchmark. Currently, Au electrodes show the best performance, whereas non-precious metal catalysts exhibit inferior activity. Here we show a densely populated Ni single-atom on nanoparticle catalyst (NiSA/NP) via direct solid-sate pyrolysis, where Ni nanoparticles donate electrons to Ni(i)-N-C sites via carbon nanotubes network, achieves a high CO current of 352 mA cm− 2 at -0.55 V vs RHE in an alkaline flow cell. When coupled with a NiFe-based oxygen evolution anode into a zero-gap membrane electrolyser, it delivers an industrial-relevant CO current of 310 mA cm− 2 at a low cell voltage of -2.3 V, corresponding to an overall energy efficiency of 57%. The superior CO2 electroreduction performance is attributed to the enhanced adsorption of key intermediate COOH* on electron-rich Ni single atom, together with the dense active sites.
The University of West Florida Campus Ecosystem Study: Age-Diameter and Growth Relationships of Longleaf Pine Using Hurricane-Induced Windthrows
Authors: Gilliam Frank S. , Patten Heather N. , Rabinowitz Sarah K. 
Published: September 2021

Abstract
The campus of the University of West Florida was constructed among second-growth longleaf pine (Pinus palustris) stands that survived extensive logging in the Florida Panhandle. Previous studies on longleaf pine on the main UWF campus have estimated that 65% of these pines are 75 to 125 years old, with estimates based on a model from old-growth longleaf in southern Georgia. To obtain more accurate age data, one can use an increment corer to collect samples from live trees on site; more accurately, disks can be collected from recently fallen trees. On 16 September 2020, Hurricane Sally impacted UWF as a Category 2 storm, with winds reaching 125 kph. Our study took advantage of longleaf pines blowdowns by Sally to obtain cross-sections for age determinations. Two on-campus natural areas were chosen for sampling: the Edward Ball Nature Trail and the Baars-Firestone Wildlife Sanctuary. For each sampled section, diameter at breast height (DBH) and number of annual rings were recorded. Based on a total of 50 sampled trees, linear regression revealed a highly significant (P<0.00001; r2 =0.84) relationship between DBH and age. Applying this to DBH measures of 2,165 stems on the main campus indicates that the oldest longleaf pines are ~130 years old (mean age = 63.9±0.4 yr), consistent with cessation of historically wide-spread harvesting in the region. Mean age for the Trails site (55.7±1.6 yr) was significantly lower than that of the Sanctuary (66.7±2.0 yr), suggesting that they represented sites of contrasting land-use history. Direction of stem windthrows did not vary between natural areas and was consistent with characteristics of the eyewall of Hurricane Sally with strongest wind gusts moving from a southeast to northwest direction.
Design and Experimental Study of Progressive Spring for Formula Student Race Car
Authors: Patil Anmol Shripad , Nandi Eshita , Punekar Prasad Nanasaheb , Wagh Suyash 
Published: September 2021

Abstract
The purpose of carrying out the present work is to design, manufacture & test the progressive springs on an FS vehicle. This is one type of helical spring with a variable spring rate. The main purpose of designing progressive springs is to avail all the advantages of the variable spring rate over the linear spring rate and better ride quality along with roll control, compared to linear rate springs. We took several factors of vehicle dynamics under consideration before settling on progressive springs. Before starting with the design procedure, we had set objectives and followed the standard methodology of spring design to get the required output. Along with that, we took design philosophy under consideration. We reviewed all the parameters before finalizing the spring material as it is one of the major factors. We carried out all the necessary design calculations to complete the dimensions and stiffness of the spring. The conclusion helped us to achieve better ride quality and roll control accompanying the optimized spring design satisfying all the necessities such as load, stiffness, and deflection of progressive springs.
Intrinsic ferroelectricity in Y-doped HfO2 thin films
Authors: Yu Yun , Buragohain Pratyush , Li Ming , Ahmadi Zahra , Zhang Yizhi , Li Xin , Wang Haohan , Tao Lingling , Wang Haiyan , Shield Jeffrey , Tsymbal Evgeny , Gruverman Alexei , Xu Xiaoshan 
Published: September 2021

Abstract
Ferroelectric HfO2-based materials hold great potential for widespread integration of ferroelectricity into modern electronics due to their robust ferroelectric properties at the nanoscale and compatibility with the existing Si technology. Earlier work indicated that the nanometer crystal grain size was crucial for stabilization of the ferroelectric phase of hafnia. This constraint caused high density of unavoidable structural defects of the HfO2-based ferroelectrics, obscuring the intrinsic ferroelectricity inherited from the crystal space group of bulk HfO2. Here, we demonstrate the intrinsic ferroelectricity in Y-doped HfO2 films of high crystallinity. Contrary to the common expectation, we show that in the 5% Y-doped HfO2 epitaxial thin films, high crystallinity enhances the spontaneous polarization up to a record-high 50 µC/cm2 value at room temperature. The high spontaneous polarization persists at reduced temperature, with polarization values consistent with our theoretical predictions, indicating the dominant contribution from the intrinsic ferroelectricity. The crystal structure of these films reveals the Pca21 orthorhombic phase with a small rhombohedral distortion, underlining the role of the anisotropic stress and strain. These results open a pathway to controlling the intrinsic ferroelectricity in the HfO2-based materials and optimizing their performance in applications.
Dynamic Analysis of Serum MMP-7 and Its Relationship with Disease Progression in Biliary Atresia: A Multicenter Prospective Study
Authors: Chi Shuiqing , Xu Peipei , Yu Pu , Cao Guoqing , Wang Haibin , Ye Yongqin , Li Shuai , Zhou Yun , Li Xiangyang , Zhou Ying , Zhang Xi , Niu Huizhong , Xu Lei , Cai Pengcheng , Tang Shaotao 
Published: September 2021

Abstract
PurposeWe aimed to assess the dynamic changing trend of serum matrix metalloproteinase-7 (MMP-7) in BA patients from diagnosis to LTx to further elucidate its clinical value in diagnosis and prognoses and its relationship with disease progression.MethodsIn this multicentre prospective study, a total of 440 cholestasis patients (direct bilirubin level of > 17 μmol/L) were enrolled. Serum and stool MMP-7 levels were measured using an enzyme-linked immunosorbent assay at different time points and analysed. The polymorphism of MMP-7 was assessed to explore the possible reasons for the low value in BA patients.Results:In neonate biliary atresia patients, using a cut-off value of > 26.73 ng/ml, serum MMP-7 had a AUC of 0.954. A genetic mutation (G137D) and rapid degradation of MMP-7 in serum samples could cause low MMP-7 levels in serum of BA patients. Four dynamic patterns of serum MMP-7 post-KPE were associated with prognosis. A high concentration of MMP-7 in the stool is linked to a decreased serum MMP-7 concentration. MMP-7 showed a mediation effect on the association between inflammation and liver fibrosis in BA patients. Serum MMP-7 was the only significant predictor at six weeks post-KPE and the most accurate predictor at three months post-KPE of survival with the native liver (SNL) in two years.Conclusion:As one of the critical factors associated with BA occurrence and progression, serum MMP-7 can be used for early diagnosis of BA and post-KPE MMP-7 level is the earliest prognostic biomarker so far.
Higher Nursing Care Level is Associated with Higher Incidence of Blood Culture Contamination in the Emergency Department: A Case-Control Study
Authors: Shigeno Ayami , Homma Yosuke , Matsumoto Taiga , Tanaka Shun , Onodera Ryuta , Oda Rentaro , Funakoshi Hiraku 
Published: September 2021

Abstract
Background

Blood culture is critical in treating infectious diseases, but contamination occurs in 0.6–12.5% of all samples. This leads to unnecessary intervention, inappropriate antibiotic use, and excess cost. Few studies have tackled patient factors, such as nursing care level, that could possibly affect contamination rates. Thus, this study aimed to explore the association between patients’ nursing care levels and blood culture contamination.
Methods

This is a single centered, retrospective, case-control study of adult patients whose blood culture specimens were taken in the emergency department between April 2018 and July 2019. The study was conducted in a 344-bed, urban, acute care community hospital in Chiba prefecture, Japan. We included patients aged 20 years and above, with two or more sets of blood cultures. The case group included patients with false positive blood culture results with contamination; the control group included patients with true positive or true negative blood culture results without contamination. We randomly selected two control patients per case. Patients’ age, sex, nursing care level, ambulance usage, housing status, Glasgow Coma Scale, and hospital arrival time were obtained from the patients’ medical charts.
Results

Of the 5,130 patients, 686 patients got positive blood culture results. Of the 686 patients, 35 patients were included in the case group, and 70 were randomly selected from the non-contaminated group and included in the control. In multivariate analysis, patients with contaminated blood cultures had a higher nursing care level (odds ratio: 5.24; 95% confidence interval: 1.47 to 18.70; P = 0.02).
Conclusions

A higher nursing care level is associated with a higher incidence of blood culture contamination in the emergency department. Careful and appropriate procedures are required for patients with a higher nursing care level.
The Association of the Consumption Time for Different Food with the Cardiovascular Disease and All-Cause Mortality Among Diabetes Patients
Authors: Jiang Wenbo , Song Qingrao , Zhang Jia , Chen Yunyan , Sun Changhao , Li Ying , Han Tianshu , Wei Wei 
Published: September 2021

Abstract
Background: This study aims to investigate whether food consumed time and distribution at three-meals is associated with long-term survival among the people with diabetes. Methods:This study included 4,699 diabetes patients participating in the National Health and Nutrition Examination Survey from 2003 to 2014. Food consumed across a day including the forenoon, afternoon, evening, were divided into quantiles based on their distribution. Cox proportional hazards regression models were used to analyze the survival relationship between food intakes time and distribution (with a constant quality and quantity) and mortality. Results:After adjustment for multiple covariates, in the forenoon, compared to the participants with diabetes in the lowest consumption quantile of potato and starchy-vegetable, participants with diabetes in the highest consumption quantile had lower mortality risk of CVD(HRpotato=0.52, 95%CI: 0.38-0.87; HRstarchy-vegetable= 0.51, 95%CI: 0.29-0.90). In the evening, the highest quantile of dark-vegetable intake is related to lower mortality risk of CVD(HR=0.64, 95%CI: 0.45-0.92) and all-cause(HR=0.81, 95%CI: 0.66-0.99), whereas participants in the highest quantile of intakes of refined grain and processed meat are more likely to die due to CVD(HRrefined-grain=1.54, 95%CI:1.10-2.15; HRprocessed-meat=1.83, 95%CI:1.20-2.77) and all-cause(HRrefined-grain=1.29, 95%CI:1.01-1.65; HRprocessed-meat=1.37, 95%CI:1.06-1.75). Iso-calorically switching 0.1 serving refined grain or processed meat consumed in the evening to the forenoon, and 0.1 serving dark vegetable consumed in the afternoon to the evening reduced the risk of CVD mortality.Conclusions:Higher intake of potato, starchy-vegetable in forenoon, dark-vegetable in the evening, and lower intake of refined-grain and processed-meat in the evening was associated with better long-term survival in people with diabetes.
Atypical Papillary Thyroid Carcinoma with Squamous Metaplasia and RET/NRAS/TERT/PIK3CA Mutations: A Case Report
Authors: Li Zhenyu , Huang Haiping , Guo Dongfang , Feng Yujie , Zhang Jing , Jiang Qingming 
Published: September 2021

Abstract
Background: Papillary thyroid carcinoma (PTC) with squamous metaplasia is a relatively rare and special subtype adenocarcinoma of thyroid which involves multiple genetic changes. We reported a rare case of atypical PTC with squamous metaplasia and RET/NRAS/TERT/PIK3CA mutations which was confirmed after surgical resection pathologically. Case summary: A 2.5×2.5×2 cm3, smooth, hard, clear boundaries and solid nodule on the left thyroid gland was found on relevant physical examination of the patient. And then, the unilateral radical resection of thyroid carcinoma was performed after diagnosing. The tumor cells were squamous metaplasia and arranged in structures with diffuse growth pattern microscopically. At high magnification, stretched nucleus, nuclear grooves and internuclear pseudoinclusions in tumor cells were detected, and the follicular epithelium cells were atypical. Immunohistochemical staining shown strong positiveness of CK19, TTF-1, P40 and Galectin-3, partial positiveness of TG of tumor cells and negativeness of Calcitonin, which could exclude medullary thyroid carcinoma (MTC). Furthermore, first generation sequencing of 18 PTC related genes techniques shown RET, NRAS, TERT and PIK3CA was mutated. Conclusion: Genetic detection is vital to the diagnosis of thyroid adenocarcinoma, especially for the PTC with atypical morphology or rare metaplasia
Real Life Experience of Patients With Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma Treated With Neoadjuvant Chemotherapy: a Turkish Oncology Group Study
Authors: Basoglu Tugba , erol cihan , sakin abdullah , özden ercan , çabuk devrim , çılbır ebru , özyükseler deniz tataroğlu , ayhan murat , şendur mehmet ali , doğan mutlu , öksüzoğlu berna , eryılmaz melek karakurt , er özlem , taşçı elif şenocak , doğan nelihan , dülgar özgecan , özen miraç , hacıbekiroğlu ilhan , öner irem , bekmez esma türkmen , yıldırım hasan çağrı , yalçın şuayib , paydaş semra , yekedüz emre , aksoy asude , özçelik melike , oyman abdilkerim , almuradova elvina , karabulut bülent , demir nazan , dinçer murat , erdem dilek , ak naziye , inal ali , salim derya kıvrak , deniz gülhan ipek , gülmez ahmet , kaçan turgut , özdemir özlem , alan özkan , ünal çağlar , turhal serdar , karakaş yusuf , yumuk perran fulden 
Published: September 2021

Abstract
PurposeNeoadjuvant chemotherapy(NACT) in gastroesophageal junction(GEJ) and gastric cancer(GC) was shown to improve survival in recent studies. We aimed to share our real-life experience of patients who received NACT in order to compare the efficacy and toxicity profile of different chemotherapy regimens in our country.Methods This retrospective multicenter study included locally advanced GC and GEJ cancer patients who received NACT, and had pathological response evaluation between 2007 and 2021. Relation between CT regimens and pathological evaluation were analyzed. Results A total of 728 patients from 45 oncology centers in Turkey were included. Median age at the time of diagnosis was 60 (range: 18-68). Most frequent NACT regimens used were FLOT (65%), DCF (18%) and ECF (8.1%), respectively. In the total study group pCR rate was 8.2%, R0 resection rate 88.5%, and D2 dissection rate was 66.8%. Rate of pCR and near-CR (26.4%), and R0 resection (92.6%) were higher in FLOT arm (p= 0.005 and <0.001). Patients who received FLOT had significantly higher chemotherapy-related toxicity rate compared to patients who received other regimens (p=0.02).Median follow-up time was 17 months (range: 3-106 months). Estimated median overall survival (OS) was 59.4 months (95% CI: 32.9-86.0) and disease-free survival (DFS) was 47.6 months (95% CI: 24.4-70.8). The highest 5-year estimated OS rate was also shown in FLOT arm (58%). ConclusionIn our real-life study, FLOT regimen has superior survival outcome despite worse toxicity profile. Clinicians should tailor treatment regimens according to patients’ multifactorial status and comorbidities for to obtain best outcomes.
The Decrease In The Anxiolytic Effect of Morphine After Repeated Use of The Drug In Rats is Associated With Inflammatory Cytokine Signaling Pathways In The Prefrontal Cortex
Authors: Ahmadi Shamseddin , Talvar Shiva Mohammadi , Masoudi Kayvan , Zobeiri Mohammad 
Published: September 2021

Abstract
We aim to examine anxiety-like behaviors and expression of specific genes complicated in neuroinflammation in the prefrontal cortex (PFC) after repeated use of morphine. A group of male Wistar rats received injections of morphine (10 mg/kg) twice a day for eight days while a control group received saline (1 ml/kg) instead of morphine. On days 1 and 8, anxiety-like behaviors were evaluated using a light/dark box test. On day 8, opioid dependence was confirmed by measuring the behavioral expression of morphine withdrawal precipitated with naloxone. Expression of neuroinflammation genes were also evaluated at mRNA levels in the PFC on day 8. The results revealed that morphine induced anxiolytic-like effects on day 1, which significantly decreased after the repeated injection of the drug on day 8. The results also revealed that repeated morphine injection significantly increased the mRNA level of Il1, Tnfα, and Il6 but decreased Il1r and Tnfr while increased Il6r in the PFC. The gene expression results also revealed a significant decrease in Tlr1 but not in Tlr4 in the PFC of morphine-dependent rats. Although Erk1 expression had no significant alteration but p38 increased and Jnk3 decreased significantly in the PFC in morphine-dependent rats. Creb and Nfkb significantly increased but Fos expression decreased. Let-7c, mir-133b, and mir-365 also significantly increased in the PFC in morphine-dependent rats. We conclude that the alteration in neuroinflammatory pathways at gene expression level in the PFC may party underlie neuroadaptive changes leading to the decrease in anxiolytic effect of morphine in dependent rats.