bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthognathic surgery-first approach with lingual appliances: a case report
Authors: Pamukçu Hande , Özsoy Serhat , Tüz Hakan H. , Polat-Özsoy Ömur 
Published: December 2021

Abstract

Background
A surgery-first approach has many advantages related to a shortened treatment time and an immediate facial aesthetic improvement compared to a three-stage conventional orthognathic surgery protocol.

Objective
The aim of this case report was to describe the treatment of a 21-year-old, female, patient who presented with a skeletal Class III malocclusion, maxillary retrusion, a negative overjet, an anterior and bilateral posterior cross-bite, and a vertical facial pattern highlighted by a high mandibular plane angle.

Methods
Orthodontic treatment was performed using self-ligating lingual appliances and a surgery-first approach. The active treatment time was 16 months.

Results and conclusion
Successful treatment results were achieved using a combination of an orthognathic surgery-first approach and lingual appliances in a patient with high aesthetic expectations.
The use of Hajj fund for investment purpose: a maqashid sharia approach
Authors: Muheramtohadi Singgih 
Published: December 2021

Purpose - Hajj financial use The Hajj is an obligation for Muslims who can carry out. Over time, the number of people who perform Hajj is increasing, but the quota is minimal. It raises new problems; one of them is the problem of the financial management of Hajj. The financial of Hajj accumulates and inflation occurs every year. One of the solutions to the financial problem in Hajj is to invest in a productive field. The purpose of this paper is to find out the Islamic scholars’ consideration of the justification of using Hajj fund and investing it in productive fields.Method - This research is conducted through a qualitative descriptive approach.Result - All Islamic organizations in Indonesia, especially MUI (Majelis Ulama Indonesia/ Indonesian Ulama Council), justify the Hajj financial use.Implication - The result can be used by society as information and consideration regarding Hajj and the mechanism of financial management in religious prayers administered by the government.Originality - This research study the recent existence of investment purposes in Hajj fund management.
The implementation of PSBB on the development of retail MSMEs with the COVID-19 pandemic as a moderating variable
Authors: Trihudiyatmanto M 
Published: December 2021

Purpose – This study aims to analyse the effect of the implementation of PSBB on the development of Retail MSMEs (micro, small, and medium enterprises).Method – Respondents in the study were 100 respondents. The sampling technique used in this study was purposive sampling, with the criteria for Retail MSMEs actors in Garung District, Wonosobo Regency, and at least the business had been operating for one year. The data analysis technique used in this research was SEM Smart PLS.Result – The development of Retail MSMEs was significantly influenced by the implementation of PSBB and was moderated by the Covid-19 pandemic. Implication – This study can assist businesses and the government during a pandemic outbreak.Originality – This is the first study examining the influence of a pandemic outbreak on the development of MSMEs in the retail industry.
The implementation of good corporate governance at Baitut Tamwil Muhammadiyah (BTM) Tegal
Authors: Hidayat Arip 
Published: December 2021

Purpose – Author studied the implementation of good corporate governance in a context of microfinance institution. Corporate Governance is a very strategic determining factor for the progress of a company in order to continuously increase value and maintain an ongoing and sustainable growth process.Method – Sources of data used in this study were taken from primary data and secondary data. Apart from interviews, other primary data source categories include reviewing, reading several global financial reports and standard operating procedure (SOP). Secondary data were obtained from books as a complement to primary data sources. Additional secondary data source of this research was obtained by conducting literature reviews.Result – Modern pondok of Tazakka uses at least six different waqf program as a financial source of their activities. These programmes are asset waqf, cash waqf, productive waqf, benefits waqf, profession waqf, and transfer of rights waqf. The programmes help the pondok to be more autonomous and able to provide various benefits for the scholars of the pondok and the people surround it. Implication – The results show that the Baitut Tamwil Muhammadiyah (BTM) implemented a good corporate governance.Originality – This study has enriched an empirical study of corporate governance in microfinance institution in Indonesia.
Waqf empowerment for the autonomy of Islamic boarding school (pesantren); study of modern Islamic boarding school (pondok) Tazakka Batang
Authors: Mahmassani Subhi 
Published: December 2021

Purpose – This study aims to study waqf instrument developed by modern Islamic boarding school (pondok) Tazakka, Batang.Method – This study is a qualitative field research, which utilizes observation, interview, and documentation. The character of this research is descriptive analysis.Result – Modern pondok of Tazakka uses at least six different waqf program as a financial source of their activities. These programmes are asset waqf, cash waqf, productive waqf, benefits waqf, profession waqf, and transfer of rights waqf. The programmes help the pondok to be more autonomous and able to provide various benefits for the scholars of the pondok and the people surround it. Implication – This research gives illustration of waqf management in an Islamic boarding school. By understanding the mechanism of the waqf management, hopefully Islamic boarding schools in Indonesia able to empower themselves better.Originality – A lot of Islamic boarding schools use waqf for his research is among the few researchs which taking a perspective of empowering religious social organization in Indonesia.
White Matter Microstructure is Associated with Serum Clusterin and
Everyday Functioning in a Sample of Nondemented Older Adults
Authors: Clark Alexandra L. , Solders Seraphina K. , Thomas Kelsey R. , Bangen Katherine J. 
Published: December 2021

Background:
Although clusterin-a protein involved in lipid metabolism, amyloid beta
clearance, and myelination-has been linked to gray matter atrophy within samples of older adults at
risk for Alzheimer’s disease, research exploring associations with white matter (WM) micro- and
macro- structural markers are largely limited.

Objective::
The current study [1] explored associations between serum clusterin protein levels and
WM micro- and macro- structural markers, and [2] clarified whether variations in WM fractional
anisotropy (FA) were associated with functional abilities within in a racially homogenous sample
of relatively well-educated older adults free of dementia.

Methods:
Participants underwent magnetic resonance imaging (MRI) brain exams and a blood
draw and completed a performance-based measure of everyday functioning. Multiple linear regression
adjusting for age, sex, APOE e4 positivity, and vascular risk were used to explore serum clusterin
associations with WM metrics, as well clarify potential links between WM microstructure and
everyday functioning.

Results:
Higher serum clusterin was associated with lower FA in several thalamocortical (anterior
and posterior internal capsule, posterior thalamic radiation; ßs = -.32 to -.37, ps = .01 to .02) and association
fiber tracts (external capsule, superior longitudinal fasciculus; ßs = -.32 to -.40, ps = .02).
Serum clusterin was not associated with white matter hyperintensity volume (ß = .14, p = .28), but
higher FA of several WM tracts was associated with better performance on the Independent Living
Scale (ßs = .37 to .53, ps = .006 to .03).

Conclusion:
Serum clusterin is differentially associated with WM metrics, and WM microstructure
is associated with everyday functioning.
Animal Placental Therapy: An Emerging Tool for Health Care
Authors: Gupta Madhu , Mumtaz Sayed Md. , Goyal Ramesh K. , Ameen A. Najeerul , Alexandrovich Bazikov Igor 
Published: December 2021

Background:The placenta maintains and regulates the growth of fetus and consists of various biologically active nutrients such as cytomedines, vitamins, trace elements, amino acids, peptides, growth factors, and other biologically active constituents.Introduction:The therapeutic effectiveness of the placenta can be well defined with respect to several biochemical mechanisms of various components present in it. The placental extract derived from biomedical wastes has also shown a great potential for treatment of various diseases.Method:Placental therapy has been reported specifically to have potent action in the treatment of diseases and tissue regeneration.Result:Placental bioactive components and their multi-targeting identity prompted us to compile the précise information on placental extract products. However, some findings are needed to be explored by scientific community to prove their clinical potential with significant statistical validation.Conclusion:In the light of available information and the usefulness of the placental extract, it is necessary that the formulations of various desirable properties may be developed to meet the clinical requirements in several treatment paradigms. The potential effects of placental extract-based therapy are an interesting topic for investigation.
Improvisation and Communicative Agency: Contribution of an Improvisational Model to the Analysis of Communicative Agency
Authors: Lie Håkon , Nafstad Anne V. 
Published: December 2021

Introduction: Persons with congenital deafblindness mainly communicate using the bodily tactile modality. Their expressive communication is often formulated by an authentic language that gives the persons with congenital deafblindness low readability towards the rest of the world. This can be an obstacle for the development of their communicative agency. In the present study it is investigated whether a theoretical approach to improvisation can contribute to the development of communicative agency in a person with congenital deafblindness with low readability and authentic language in a dialogical perspective.
Method: The study employs a qualitative design conducted as a dialogical single case study. Even though this research is based only on one recording of a communicative encounter between a person with deafblindness and her communication partner, it is assumed that the study can be used as a representative case study for people with low readability and authentic language.
A video of communication between a person with CDB and a sighted/hearing communication partner is transcribed and the transcription is analysed in three stages through 1) Conversational analysis (CA), 2) Improvisation analysis and 3) Subjectivity/intersubjectivity analysis.
Results: The Conversation analysis proved useful to identify complex turn-taking patterns in the communication. Through the improvisation model it was possible to define the degree of subjectivity/intersubjectivity in every utterance by each participant, as well as how each act was met by the other. With the improvisation model discriminations could be made between the different modalities, as vocal speech and bodily tactile acts. Regarding communicative agency, the model was useful to analyze degrees of self-expression as well as the balance of subjectivity and intersubjectivity between the participants.
Conclusion and discussion: The model of improvisation contributed to specify subjectivity/intersubjectivity and multimodality in communication, though it did not contribute to the analysis of turn-taking. The model contributed to the development of communicative agency by pointing to the open-ended outcome for each utterance as the most important factor for developing and sustaining communicative agency.
Limitations: The main limitation of this study was that the analyses were performed on only one video-clip with one dyad. Due to time constraints, a consensus check could not be carried out. Recommendations for future research is that, since this is a very innovative method in the deafblind field, replications of the study should be performed on more dyads, different dialogues and more video clips.
Recommendation for practice: The combination of conversation analysis and improvisation analyses can very well be used with focus groups of care professionals in clinical practice under supervision of a trained expert in this method of communication analyses.
Optimizing Existing Mental Health Screening Methods in a Dementia Screening and Risk Factor App: Observational Machine Learning Study
Authors: Kuleindiren Narayan , Rifkin-Zybutz Raphael Paul , Johal Monika , Selim Hamzah , Palmon Itai , Lin Aaron , Yu Yizhou , Alim-Marvasti Ali , Mahmud Mohammad 
Published: December 2021

Background
Mindstep is an app that aims to improve dementia screening by assessing cognition and risk factors. It considers important clinical risk factors, including prodromal symptoms, mental health disorders, and differential diagnoses of dementia. The 9-item Patient Health Questionnaire for depression (PHQ-9) and the 7-item Generalized Anxiety Disorder Scale (GAD-7) are widely validated and commonly used scales used in screening for depression and anxiety disorders, respectively. Shortened versions of both (PHQ-2/GAD-2) have been produced.

Objective
We sought to develop a method that maintained the brevity of these shorter questionnaires while maintaining the better precision of the original questionnaires.

Methods
Single questions were designed to encompass symptoms covered in the original questionnaires. Answers to these questions were combined with PHQ-2/GAD-2, and anonymized risk factors were collected by Mindset4Dementia from 2235 users. Machine learning models were trained to use these single questions in combination with data already collected by the app: age, response to a joke, and reporting of functional impairment to predict binary and continuous outcomes as measured using PHQ-9/GAD-7. Our model was developed with a training data set by using 10-fold cross-validation and a holdout testing data set and compared to results from using the shorter questionnaires (PHQ-2/GAD-2) alone to benchmark performance.

Results
We were able to achieve superior performance in predicting PHQ-9/GAD-7 screening cutoffs compared to PHQ-2 (difference in area under the curve 0.04, 95% CI 0.00-0.08, P=.02) but not GAD-2 (difference in area under the curve 0.00, 95% CI –0.02 to 0.03, P=.42). Regression models were able to accurately predict total questionnaire scores in PHQ-9 (R2=0.655, mean absolute error=2.267) and GAD-7 (R2=0.837, mean absolute error=1.780).

Conclusions
We app-adapted PHQ-4 by adding brief summary questions about factors normally covered in the longer questionnaires. We additionally trained machine learning models that used the wide range of additional information already collected in Mindstep to make a short app-based screening tool for affective disorders, which appears to have superior or equivalent performance to well-established methods.
Economic Burden of Chronic Obstructive Pulmonary Disease and Lung Cancer Between 2000 and 2015 in Saskatchewan: Study Protocol
Authors: Penz Erika Dianne , Fenton Benjamin John , Hu Nianping , Marciniuk Darcy 
Published: December 2021

Background
Chronic obstructive pulmonary disease (COPD) and lung cancer are both detrimental diseases that present great burdens on society. Years of life lost (YLL), premature years of life lost (PYLL), working years lost (WYL), and productivity loss are all effective measures in identifying economic burden of disease.

Objective
We propose a population-based study to analyze comprehensive provincial cohorts of Saskatchewan residents with COPD, lung cancer, and combined COPD and lung cancer in order to identify the burden these diseases present.

Methods
Saskatchewan residents over the age of 35 years who had COPD, lung cancer, or both, between January 1, 2000, and December 31, 2015, will be identified and used in this study. Data for analysis including age, gender, and date of death, alongside Statistics Canada income estimates, will be used to estimate productivity loss and WYL. Statistics Canada life tables will be used to calculate YLL and PYLL by subtracting the patients’ ages at death by their life expectancies, adjusted using sex and age at death.
We will link the Saskatchewan cancer registry with Saskatchewan health administrative databases to create three cohorts: (1) COPD; (2) lung cancer; and (3) COPD and lung cancer. Individuals with lung cancer will be identified using ICDO-T (International Classification of Diseases for Oncology-Topography) codes, and those with COPD will be defined and identified as individuals who had at least 1 visit to a physician with a diagnosis of COPD or 1 hospital separation with a diagnosis of COPD. Those without a valid health care coverage for a consecutive 12 months prior to the first diagnostic code will be excluded from the study. Those with a combined diagnosis of COPD and lung cancer will be identified as individuals who were diagnosed with COPD in the 12 months following their lung cancer diagnosis or anytime preceding their lung cancer diagnosis.

Results
As of April 2021, we have had access to all relevant data for this study, have received funding (January 2020), and have begun the preliminary analysis of our data set.

Conclusions
It is well documented that COPD and lung cancer are both destructive diseases in terms of YLL, PYLL, WYL, and productivity loss; however, no studies have been conducted to analyze a cohort with combined COPD and lung cancer. Understanding the economic burden associated with each of our 3 cohorts is necessary in understanding and thus reducing the societal impact of COPD and lung cancer.

International Registered Report Identifier (IRRID)
RR1-10.2196/31350
A Novel Digital Self-management Intervention for Symptoms of Fatigue, Pain, and Urgency in Inflammatory Bowel Disease: Describing the Process of Development
Authors: Sweeney Louise , Windgassen Sula , Artom Micol , Norton Christine , Fawson Sophie , Moss-Morris Rona 
Published: December 2021

Background
Empirical studies and systematic reviews have demonstrated the role of biological, cognitive, behavioral, and emotional factors in fatigue, pain, and urgency in inflammatory bowel disease (IBD). Behavioral management that addresses the cognitive, behavioral, and emotional factors offered alongside medical treatment is seldom available to people with IBD. Digital interventions provide a potentially scalable and cost-effective way of providing behavioral support to patients.

Objective
This paper aimed to describe the process of developing a supported digital self-management intervention for fatigue, pain, and urgency in IBD using theory and evidence-based approaches and stakeholder input.

Methods
The Medical Research Council framework for complex health interventions and a person-based approach were used to guide intervention development, consulting with 87 patients with IBD and 60 nurses. These frameworks informed the selection and use of a theoretical model that subsequently guided cognitive behaviorally based intervention content. They also guided the design of tailored digital intervention pathways for individuals with IBD that matched the predominant symptoms.

Results
A transsymptomatic cognitive behavioral framework of symptom perpetuation was developed for the symptoms of fatigue, pain, and urgency in IBD. A logic model was used to define the intervention techniques. Patient feedback and qualitative interviews refined the website content and functionalities, including the use of visual aids, email reminders, and graphical tracking of symptoms. Nurse focus groups informed the volume and delivery model of the therapist facilitator support. Ratings of acceptability out of 10 following feasibility testing (31/87, 36%) demonstrated accessibility (scoring 9.43, SD 1.040), ease (scoring 8.07, SD 3.205), clarity, and the relevant tone of the intervention. The final intervention comprised 12 web-based sessions (8 core and 4 symptom-specific), with one 30-minute facilitator phone call following session 1 and subsequent on-site messaging.

Conclusions
The use of theory and integration of stakeholders’ views throughout informed the development of an evidence-based digital intervention for fatigue, pain, and urgency in IBD. This is the first web-based self-management intervention designed to address these multiple symptoms with the aim of improving the quality of life and reducing the symptom burden of IBD. The intervention is being tested in a large multicenter randomized controlled trial.

Trial Registration
ISRCTN Registry ISRCTN71618461; https://www.isrctn.com/ISRCTN71618461
Influence of Maternal Exposure to Mass Media on Growth Stunting Among Children Under Five: Mediation Analysis Through the Water, Sanitation, and Hygiene Program
Authors: Huo Shutong , Wang Kai , Liu Zongchao , Yang Yuao , Hee Jia Yi , He Qiwei , Takesue Rie , Tang Kun 
Published: December 2021

Background
The issue of malnutrition in the Democratic Republic of Congo is severe. Meanwhile, the Water, Sanitation, and Hygiene program has been demonstrated to be effective in reducing the rates of growth stunting among children.

Objective
We aimed to explore the association between maternal exposure to mass media and stunting in children through water, sanitation, and hygiene behaviors.

Methods
Mediation analysis was conducted using data from the 2018 Multiple Indicators Cluster Surveys.

Results
Mothers’ exposures to television and the internet in the Democratic Republic of Congo significantly decreases the risk of stunting in children by 5% and 10%, respectively, mediated by household water, sanitation, and hygiene facilities and practices.

Conclusions
These findings could inform interventions and policies to reduce the rate of stunting rate children by promoting water, sanitation, and hygiene through mass media, especially through the internet and television.
PENGARUH BAURAN PROMOSI TERHADAP KEPUTUSAN PEMBELIAN DITINJAU DALAM PERSPEKTIF EKONOMI ISLAM (STUDI KONSUMEN TOKO RATU TEXTILE BANDA ACEH)
Authors: Kinanti Mutiara , Hafidhah Hafidhah , Rina Aida 
Published: December 2021

Abstrak
Penelitian ini dilakukan di toko Ratu Textile pada konsumen yang pernah melakukan pembelian ulang. Penelitian ini bertujuan untuk melihat “Pengaruh Bauran Promosi Terhadap Keputusan Pembelian ditinjau dalam Perspektif Ekonomi Islam (Studi Konsumen Toko Ratu Textile Banda Aceh”. Variabel yang diambil pada penelitian ini adalah periklanan, promosi penjualan dan penjualan pribadi. Penelitian ini merupakan penelitian kuantitatif, dimana sampel yang diambil sebanyak 125 responden yaitu seluruh pelanggan toko Ratu Textile di Banda Aceh. Data yang digunakan adalah data primer yaitu mengedarkan daftar pertanyaan dalam bentuk kuesioner. Metode analisis penelitian dilakukan menggunakan regresi linear berganda. Hasil penelitian ini menunjukkan bahwa periklanan, promosi penjualan, dan penjualan pribadi secara bersama-sama berpengaruh signifikan terhadap keputusan pembelian dibuktikan dengan Fhitung > Ftabel yaitu 56,228 > 2,68. Periklanan tidak berpengaruh signifikan terhadap keputusan pembelian hasil ini dibuktikan dengan Thitung < Ttabel 1,902 < 1,979. Promosi penjualan berpengaruh signifikan terhadap keputusan pembelian hasil ini dibuktikan dengan Thitung > Ttabel 3,098 > 1,979. Penjualan pribadi berpengaruh signifikan terhadap keputusan pembelian hasil ini dibuktikan dengan Thitung > Ttabel 6,307 > 1,979.