bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Kapasitas Ekonomi Berbasis Masyarakat Di Desa Wisata Cibuntu, Indonesia
Authors: Bahri Asep Syaiful , Suyatno Rianto 
Published: September 2021

The process of planning and decision making in the development program for this is oftenly done by top-down. Most often society is not given a choice and an opportunity to provide input. Sometimes government assistance creates dependency, which in turn would create trouble than help. The purpose of this study was to illustrate the potential of tourism and economic potential in the Cibuntu village as well as to determine the model to improve the local economy based on tourism. Samples are some families in the Cibuntu village. The results of this study indicate that the tourism and economic potential are very diverse and can support tourism activities and for the community-based model of economic improvement which can be implemented is culinary-based, homestay based and craft-based.
Analisis Sistem Informasi Akuntansi Penggajian Pada CV ABC di Jawa Tengah
Authors: Pramesti Wahyu , Trijayanti Desi 
Published: September 2021

This research was conducted at CV ABC which is engaged in the furniture industry. In managing the payroll system this company is still less effective. It can be seen from several salary payment activities to employees who still often make mistakes in the process of calculating salaries and employee attendance records. In addition, in the process of paying salaries to employees, they often experience late payments. The purpose of this study is to analyze the payroll accounting information system in the company which is expected to help resolve the problems faced by the company. The research method used in this study is a qualitative descriptive research method. The thing that will be done by the researcher is to describe the use of payroll accounting system on CV ABC. The conclusion of this study is that the payroll system on CV ABC is already good because it has used a computerized system. The internal control in the payroll process is still weak because there are still division of tasks and responsibilities of each part that is unclear, namely there is a double duty and interdependence in working tasks, besides that supervision is still lacking for activities that should be routinely checked or corrected.
Knowledge Base Design for Diagnosis Pregnancy Problems
Authors: Arzumni Farah Rifdah , Indahsari Rina Dewi 
Published: September 2021

In Indonesia, the death rate of pregnant women was still very high. Lack of knowledge about the perceived symptoms during pregnancy make pregnant women regardless of the specific symptoms that can be harmful and disease records indicate the causes of indirect maternal death in pregnant. Moreover, the risk of pregnant mother mortality is also higher due to the delay in taking the decision factors for referenced. Based on the fact, the proposed solution in the form of expert system diagnosis of diseases of pregnant women using the method of Backward Chaining that can help recognize diseases during pregnancy to take place based on the perceived symptoms of pregnant women as well as references that should be targeted by the patient. The methods of the Backward Chaining have a performance system that is capable of running the functional needs and high accuracy percentage results. With the existence of a system of experts on pregnancy problems that use the Backward Chaining method can describe the level of confidence of an expert on the problem at hand. Based on the test results, obtained results 100% functionality of disease diagnosis expert system of pregnant women worked in accordance with a list of system requirements and the system.
Effect of Drying Temperature on Sensory Properties of Mustard Flour (Brassica juncea) Using Oven Dryer
Authors: Ekawati Yeny , Saidi Ida Agustina 
Published: September 2021

This study aims to determine the effect of drying temperatures on sensori properties of mustard greens flour. The study was conducted from February to April 2020. Hedonic test used non-parametric statistical to determine sensori properties of mustard greens flour.The sample used was mustard greens (Brassica juncea) from Waru, Sidoarjo. Various temperature used oven drying at 40oC, 50oC,60oC and 70oC. The results showed that the drying temperatures has not difference on hedonic test of color, aroma, and texture of mustard flour.
Magnetic Resonance Imaging in Diagnosis of Complications of Renal and Ureteral Injuries in Different Periods of Traumatic Disease
Authors: Magomedova Zavazhat M. , Egorova Elena A. , Lezhnev Dmitry A. , Smislenova Margarita V. 
Published: September 2021

The aim of this study was to evaluate the effectiveness of MRI in diagnosing combined renal and ureteral injuries at different periods of traumatic disease (TD).	Methods and Results: We analyzed the results of diagnostics and treatment of 139 patients (80 women and 59 men) with renal and ureteral injuries aged between 18 and 72 years. There were 67(48.2%) patients in the period of acute reaction to trauma, 40(28.8%) patients with early manifestations, and 32(23%) patients in the period of late manifestations. In 127(91.4%) patients, an urgent plain abdominal X-ray was performed without any preliminary preparation. USI of the abdominal and retroperitoneal space was performed in 108(77.7%) patients in the stage of the primary assessment of renal injury as it was a rapid non-invasive investigation. A whole-body MSCT was performed in 131(94.2%) patients, using the nonionic contrast agents Ultravist (350mg I/ml) and Omnipaque (350mg I/ml). MRI was performed in 125(89.9%) patients, including cases of pregnancy and a medical history of allergies. Contrast-enhanced MSCT had a high diagnostic efficiency in assessing complications in kidney and ureteral injuries at different periods of TD (accuracy of 89.2% for acute reaction, 88.8% for early manifestations, and 89.5% for late manifestations). MRI of the kidneys and ureters was indicated in periods of early and late manifestations of TB to detect renal complications in cases with a discrepancy between clinical manifestations and the results obtained by ultrasound and MSCT (accuracy of 87.5% for early manifestations and 89.9% for late manifestations).
The Genotype Distribution of Human Papillomavirus among HIV-Infected Women Planning Pregnancy in Irkutsk, Russia
Authors: Belyaeva Elena , Genich Eleva , Leshchenko Olga 
Published: September 2021

The purpose of our research was to determine the detection frequency of 12 high-risk types of human papillomavirus (HPV) in women with human immunodeficiency virus (HIV) who are planning pregnancy and to assess the results of colposcopy and the state of the cervix in these women, depending on the presence of HPV.	Methods and Results: We examined 31 women with HIV infection who sought pregnancy-planning advice at Scientific Center for Family Health and Human Reproduction Problems in Irkutsk during 2014-2015. All HIV-infected women were tested for the presence of high-risk HPV DNA in the epithelium of the cervical canal by PCR. Material for cytological examination (PAP test) was collected during gynecological examination. PAP tests were assessed according to the Bethesda system. All changes were divided into two types: ASCUS and SIL, the last was in its turn divided into two categories: LSIL and HSIL.	The frequency of HPV detection in HIV-infected women planning pregnancy was 71%. HPV 16 was found in 16(51.6%) HIV-infected women and ranked first in frequency among 12 types of HPV. HPV 33 and HPV 35 were found in 15(48.4%) and 12(38.7%) HIV-infected women, respectively, and ranked the second and third in frequency among 12 HPV types. We compared abnormal colposcopy results in two groups of patients with HIV infection: Group 1 (n=22) included women with HPV and Group 2 (n=9) included women without HPV. ASCUS was detected in all patients of Group 1 (100%) and in 6(66.7%) women of Group 2. Two women (9.1%) from Group 1 were diagnosed with LSIL and 10(45.5%) women with HSIL. Conclusion: HIV-infected women planning pregnancy and living in Irkutsk form a group at high-risk of HPV infection.
The Assessment of Risk Factors for Development of Disability in Children with Congenital Hypothyroidism in Uzbekistan within a Neonatal Screening
Authors: Rakhimova Gulnara N. , Zhiemuratova Gulshad M. , Aliyevа Anna V. 
Published: September 2021

The aim of this study was to detect the most significant risk factors leading to disability in children with congenital hypothyroidism (CH) in the autonomous Republic of Karakalpakstan (RK) during neonatal screening (NS).	Methods and Results: We used data of patients with CH registered within NS in the RK in 1998-2019 by the Center for Screening of Mother and Child. To predict and calculate the most significant risk factors for disability in children with CH, we used the method of normalizing intensive indicators by E. Shigan, based on the Bayes theorem.	The study recruited 111 patients with CH aged from 2 months to 20 years. Among the patients, there were 79(71.2%) girls and 32(28.8%) boys. Additionally, 34(30.6%) children with CH had been disabled since childhood. The lack of compensation after the start of treatment had the highest and most significant degree of disability risk (RR=6.39, 95% CI: 7.4-1.2). Among patients diagnosed outside of screening, disability developed 4.1 times more often than with the results of NS (RR=4.0, 95% CI: 1.1-10.6). In CH patients diagnosed outside of screening, “absence of reagents” was a significant factor increasing the risk of disability by 6.1 times (RR=6.1, 95% CI: 1.8-11.2). Such risk factors as “home delivery” and “parental refusal of the primary test” increased the risk of disability by 3.4 times (RR=3.4, 95% CI: 2.5-8.4) and 1.6 times (RR=2.4, 95% CI: 2.93-7.12), respectively. The possible errors or false-negative answers in the “normal” secondary test and the “normal” primary test increased the risk of disability by 3.3 times (RR=4.0, 95% CI: 3.2-10.7) and 2.4 times (RR=2.42, 95% CI: 2.93-7.12), respectively. Factors such as the “late response to retesting” (RR=0.82 95% CI: 0.65-0.54), “late awareness on the part of the medical staff” (RR=0.29, 95% CI: 0.27- 0.08), and "parental refusal of treatment" (RR=1.03, 95% CI: 0.81-0.84) showed less significance in patients' disability. The “starting treatment after 1 month” factor was 4.2 times more likely to result in disability than “starting treatment before 1 month” (RR=4.2, 95% CI: 4.5 -1.1). Cancellation of levothyroxine by parents for children up to 3 years of age and cancellation of treatment by parents after 3 years more likely resulted in disability by 1.4 times (RR=1.43, 95% CI: 1.4 -2.01) and 3.3 times (RR=3.33, 95% CI: 3.3-10.9), respectively.	Conclusion: the most significant risk factors for the development of disability in children with CH in the RK were (in descending order): no compensation after starting treatment, no reagents for screening, starting treatment after 1 year, diagnostics outside of screening, cancellation of L-T4 by parents before and after age 3 years, false-negative secondary TSH test, false-negative primary test, parents refusing the primary test, and childbirth at home.
The Effectiveness of Local Conservative Therapy after Panretinal Laser Coagulation against the Background of Diabetic Neuropathy
Authors: Ponomareva Maria N. , Petrov Ivan M. , Gribanova Evgeniya K. 
Published: September 2021

Background: Panretinal photocoagulation (PRP) (also called scatter laser treatment) remains one of the effective methods of treatment, and it can help to prevent blindness and low vision in diabetic retinopathy (DR). The aim of this study was to investigate the efficacy of local prolonged conservative therapy after PRP and the effect of somatic polymorbidity on visual functions in patients with diabetic neuropathy (DN) at the stage of clinical manifestations based on monitoring the clinical, functional and morphometric parameters of the macular region of the retina.	Methods and Results: The study included 78 patients with type 2 diabetes (T2D) who underwent PRP for DR using a VISULAS® 532s solid-state laser (ZEISS). The patients were divided into two groups depending on the presence or absence of DN. Group 1 (n=60, 120 eyes) included patients with DN (stage of clinical manifestations), Group 2 (n=18, 36 eyes) included patients without DN. All patients underwent standard ophthalmological examination: visometry, tonometry, perimetry, biomicroscopy of the anterior segment of the eye and vitreous body, and fundus ophthalmoscopy. Thickness map of the retina was obtained using the RTVue-100 OCT (Optovue, Fremont, CA) EMM5 scan protocol and the Stratus OCT (Carl Zeiss Meditec, USA) radial scan protocol. After laser treatment, all patients, regardless of the treatment stage, were prescribed topically Broxinac® ( Bromfenac ophthalmic solution 0.09%), 1 drop twice a day for a month. In the presence of macular edema, a carbonic anhydrase inhibitor (Dorzolamide 2% solution) was added to the Broxinac® solution (1 drop twice a day) for up to 1 month after each PRP stage. The dynamics of CVA parameters and the retinal thickness of the macular region were assessed before PRP and 3 months after the complex treatment.	Based on the monitoring of the clinical, functional and morphometric parameters of the macular region of the retina after PRP in T2D patients, we found a local, prolonged, 3-month conservative therapy to be effective, using the instillation of Broxinac® supplemented with Dorzolamide 2% solution in the presence of macular edema. Conversely, there is a negative effect of somatic polymorbidity (stage 3 chronic kidney disease), aspartate aminotransferase >40U/L) on corrected visual acuity (CVA) and morphometric parameters of the macular region of the retina during PRP in T2D patients with DN at the stage of clinical manifestations.
Spatial Distribution of the N2 and P300 Components of the Auditory Evoked Potential in Women with Arterial Hypertension: A study in the Russian Arctic
Authors: Krivonogova Olga V. , Krivonogova Elena V. , Poskotinova Liliya V. 
Published: September 2021

The aim of this study was to evaluate the spatial distribution of the latencies and amplitudes of the N2 and P3 (or P300) components of the AEP in the Russian Arctic working-age women with different levels of BP.	Methods and Results: A total of 25 working-age women living in Nadym city for more than 20 years took part in this study. Group 1 (n=12, control group) consisted of women with BP within the normal range (<130/90 mmHg); Group 2 (n=13) consisted of women with AH (AH duration from 1 to 10 years). The parameters of the N2 and P300) components of the AEP were evaluated using an electroencephalograph (Neuron-Spectrum-4/VPM, Russia). An auditory oddball paradigm was used to elicit the oddball ERPs.	In Group 2, compared with Group 1, the N2 latency was more pronounced in the parietal (P4, P3), central (C4, C3), frontal (F4, F3), and left temporal (T3, F7) regions. The N2 amplitude in all studied brain regions in individuals of both groups was comparable. The P300 latency did not differ between the two groups. In Group 2, the P300 amplitude was significantly lower in the parietal region (P3) on the left, and in the central and temporal regions on the right (C4, T4). In Group 2, inverse correlations between DBP and the P3 amplitude were revealed in the central (C4: r=-0.88, P=0.001; C3: r=-0.86, P=0.001), frontal (F4: r=-0.76; P=0.01; F3: r=-0.93, P=0.001), and anterior-temporal cerebral regions (F8: r=-0.65, P=0.04; F7: r=-0.64, P=0.04). SBP correlated with the P3 amplitude in the right mid-temporal region (T4: r=0.64, P=0.04).	Conclusion: The features of the spatial distribution of the N2 and P3 components of the AEP can be used for early diagnosis of the risk of developing cognitive disorders in AH patients.
Direct Pharmacological Correction of Oxidative Stress in Rat Kidneys Does Not Facilitate Diabetic Nephropathy
Authors: Zharikov A. Yu. , Filinova S.O. , Mazko O. N. , Makarova O. G. , Bobrov I. P. 
Published: September 2021

The aim of this study was to evaluate the effect of alpha-tocopherol acetate (ATA) on the activity of free-radical oxidation (FRO) in renal tissue and renal function in rats with experimental streptozotocin (STZ)-induced diabetes mellitus (DM).	Methods and Results: Experiments were conducted on 22 male Wistar rats aged 60-100 days and weighing 250-300g. The animals were divided into two groups (Group 1 (control) and Group 2 (experimental. To induce DM, the animals were injected intraperitoneally 1ml of STZ solution in the citrate buffer at a dose of 65mg/kg. For more selective modeling of type 2 DM, the rats were previously injected with an intraperitoneal solution of cytoflavin based on a nicotinamide dose of 115mg/kg In Croup 2, ATA was administered in the period from the fifth to eighth weeks, inclusive, intragastrically through a tube at a daily dose of 300mg/kg. Experiments showed that after a 4-week course of ATA, the concentration of thiobarbiturate-reactive products in the kidney tissues of the rats in Group 2 was 5.3 times lower than in Group 1. The activity of all antioxidant enzymes did not differ between the two groups. In both groups, during all 8 weeks of the experiment, the levels of renal excretion of glucose, protein, and creatinine significantly exceeded the initial level, while the level of diuresis remained stable.	Conclusion: The long-term administration of ATA in experimental streptozotocin (STZ)-induced DM is accompanied by a significant suppression of the activity of the FRO processes in the kidneys, but does not lead to an improvement in the course of DN.
Biomedicine in the COVID Age: Opportunities, Responses, and Challenges
Authors: Rao Gundu H. R. 
Published: September 2021

According to one of the earliest definitions, biomedicine means “clinical medicine based on the principles of physiology and biochemistry.” Clinicians for quite some time preferred the use of the term medical research to describe what they considered the clinical findings pertaining to various issues related to clinical studies. Since the time when the basic molecules of life, deoxyribonucleic acids, were characterized and the genetic code elucidated, there has been great excitement, anticipation, and promise for the development of precision and personalized medicine. However, the progress has been considerably slow and at times disappointing. The unprecedented coronavirus disease created a worldwide panic and exposed all our weaknesses and unpreparedness. It also demonstrated a global demand for better public health infrastructure and preparedness to combat future pandemics. This unprecedented public health crisis acted as a great stimulus for putting together a concerted effort to develop vaccines. According to the experts, the time was right and within 48 hours after the information on the SARS-CoV-2 genome was posted, Moderna scientists had on paper a workable mRNA, which would code for the spike protein. The immune engineers at Moderna as well as BioNTech were able to put together a lipid nanoparticle delivery system for safe delivery of this precious cargo to the appropriate cells. Professor Cody Meissner at Tufts University School of Medicine in Boston says, “It is absolutely astonishing that this happened [COVID Vaccine development] in such a short time—to me, it is equivalent to putting a person on the Moon.” It is indeed a great achievement, and it demonstrated the power of basic science and emerging technologies.	The extraordinary success of mRNA vaccines has opened new avenues for mRNA-based therapies. mRNAs, siRNAs, and non-coding miRNAs will play a very important role as novel therapeutics soon. Furthermore, this success has acted as a catalyst for ongoing work on the use of small RNAs for therapeutic purposes. Having said that, I must say that there are a great many challenges that need to be addressed.
Polos fríos en el Calar de Hernán Pelea y Cabrilla (Jaén, España), factores sinópticos y de microescala
Authors: Espín Sánchez David , Conesa García Carmelo , Olcina Cantos Jorge 
Published: September 2021

Los extensos e inhóspitos calares ubicados en las Sierra de Segura y Cabrilla (divisoria entre las demarcaciones hidrográficas del Segura y Guadalquivir) presentan un estereotipo microclimático caracterizado por inviernos extremadamente fríos, con temperaturas mínimas absolutas cercanas a -30ºC en invierno, y -10ºC y -15ºC en otoño y primavera respectivamente. Los datos registrados han sido obtenidos de una red propia de termómetros registradores (datalogger) entre octubre de 2016 y febrero de 2021 (con un total de cinco inviernos de observación). A través del análisis estadístico de datos diezminutales y diarios de tres puntos de observación (Monterilla, Navalasno y Nava del Polvo), imágenes satelitales (VIIRS LST) y reanálisis mesoescalares es posible llevar a cabo la primera descripción climática del área de estudio, así como la identificación de los factores desencadenantes (sinópticos y de microescala) de las temperaturas mínimas extremas registradas, y el análisis de la tipología de los procesos de inversión térmica nocturna (ITN) y las piscinas de aire frío (CAP) generadas en el área de estudio. A pesar de que el tipo de piscina fría predominante es la de erosión turbulenta (39,0 %), los procesos de estabilidad nocturno son intensos (CINV entre 7,6 y 12,5ºC).
Incorporation of Neutrally Buoyant Proppants in Horizontal Unconventional Wells to Increase Propped Fracture Area Results for Substantially Improved Well Productivity and Economics
Authors: Brannon Harold , Hoffman Nicole 
Published: September 2021

Abstract
Hydraulic fracturing stimulation of unconventional wells employing large volumes of sand in low viscosity fluids provides propped fracture conductivity in less than 25% of the created fracture area, primarily because of poor sand transport mechanics. The remaining unpropped area is at best only marginally productive using the conventional sand/slickwater hydraulic fracturing process alone. Near-neutrally buoyant proppants (NBPs, ASG 1.055) have proven to be highly effective in accessing production from fracture area that is otherwise left unpropped. Fracture models illustrate the propped fracture area of designs incorporating NBPs is improved to over 85% of the created fracture area. Production simulations of typical slickwater and sand frac designs supplemented with NBPs at 3% by weight of sand distributed evenly throughout the slurry stages show cumulative production increases of 20% to greater than 50% compared to the large volume slickwater/sand treatments without NBPs.
Efforts have been directed to justification of the incremental expense involved with the NBP applications and assessment of the associated value-added economic metrics, including the value of the realized incremental production vs. time, the payback time for recovery of the incremental costs, and Return on Investment (ROI). For example, in a 2018 trial of NBP wells in the Middle Bakken formation of North Dakota, the production uplift observed for NBP wells achieved payback of the incremental costs in an average of 26 days; the 1-year cumulative oil production of the NBP wells averaged 69,632 barrels greater than control wells, resulting in a 25% uplift compared to the offset control wells. The Year 1 Return on Investment (ROI) for the drilling and completion costs of the first Middle Bakken well with NBP was 97% versus 64% for the sand-only control wells.
Controlled multi-stage horizontal completions of wells with sand-only have been evaluated against wells utilizing NBPs in the application have been executed within several unconventional plays, including the Permian and Williston basins. The performance of the NBP wells have consistently validated the production uplift predictions of the production simulation models. The case studies analyzed herein expand the economic assessment of the NBP stimulation designs by including production analyses quantitative comparison of Net Present Value, production decline rates, and projected EURs of the NBP wells and non-NBP offset wells.